id	sid	tid	token	lemma	pos
bibechana-29750	1	1	bibechana	bibechana	PROPN
bibechana-29750	1	2	18	18	NUM
bibechana-29750	1	3	(	(	PUNCT
bibechana-29750	1	4	1	1	NUM
bibechana-29750	1	5	)	)	PUNCT
bibechana-29750	1	6	(	(	PUNCT
bibechana-29750	1	7	2021	2021	NUM
bibechana-29750	1	8	)	)	PUNCT
bibechana-29750	1	9	140	140	NUM
bibechana-29750	1	10	-	-	SYM
bibechana-29750	1	11	148	148	NUM
bibechana-29750	1	12	140	140	NUM
bibechana-29750	1	13	bibechana	bibechana	NOUN
bibechana-29750	1	14	issn	issn	VERB
bibechana-29750	1	15	2091	2091	NUM
bibechana-29750	1	16	-	-	SYM
bibechana-29750	1	17	0762	0762	NUM
bibechana-29750	1	18	(	(	PUNCT
bibechana-29750	1	19	print	print	NOUN
bibechana-29750	1	20	)	)	PUNCT
bibechana-29750	1	21	,	,	PUNCT
bibechana-29750	1	22	2382	2382	NUM
bibechana-29750	1	23	-	-	SYM
bibechana-29750	1	24	5340	5340	NUM
bibechana-29750	1	25	(	(	PUNCT
bibechana-29750	1	26	online	online	ADJ
bibechana-29750	1	27	)	)	PUNCT
bibechana-29750	1	28	journal	journal	NOUN
bibechana-29750	1	29	homepage	homepage	NOUN
bibechana-29750	1	30	:	:	PUNCT
bibechana-29750	1	31	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-29750	1	32	publisher	publisher	NOUN
bibechana-29750	1	33	:	:	PUNCT
bibechana-29750	1	34	department	department	NOUN
bibechana-29750	1	35	of	of	ADP
bibechana-29750	1	36	physics	physics	PROPN
bibechana-29750	1	37	,	,	PUNCT
bibechana-29750	2	1	mahendra	mahendra	PROPN
bibechana-29750	2	2	morang	morang	PROPN
bibechana-29750	2	3	a.m.	a.m.	PROPN
bibechana-29750	3	1	campus	campus	PROPN
bibechana-29750	3	2	,	,	PUNCT
bibechana-29750	3	3	tu	tu	PROPN
bibechana-29750	3	4	,	,	PUNCT
bibechana-29750	3	5	biratnagar	biratnagar	NOUN
bibechana-29750	3	6	,	,	PUNCT
bibechana-29750	3	7	nepal	nepal	ADJ
bibechana-29750	3	8	thermal	thermal	ADJ
bibechana-29750	3	9	properties	property	NOUN
bibechana-29750	3	10	of	of	ADP
bibechana-29750	3	11	normal	normal	ADJ
bibechana-29750	3	12	and	and	CCONJ
bibechana-29750	3	13	sickled	sickled	ADJ
bibechana-29750	3	14	hemoglobin	hemoglobin	NOUN
bibechana-29750	3	15	protein	protein	NOUN
bibechana-29750	3	16	jhulan	jhulan	NOUN
bibechana-29750	3	17	powrel1,2	powrel1,2	PROPN
bibechana-29750	3	18	,	,	PUNCT
bibechana-29750	3	19	narayan	narayan	NOUN
bibechana-29750	4	1	p.	p.	NOUN
bibechana-29750	4	2	adhikari2	adhikari2	PUNCT
bibechana-29750	5	1	*	*	PUNCT
bibechana-29750	5	2	1department	1department	NUM
bibechana-29750	5	3	of	of	ADP
bibechana-29750	5	4	physics	physics	NOUN
bibechana-29750	5	5	,	,	PUNCT
bibechana-29750	5	6	butwal	butwal	VERB
bibechana-29750	5	7	multiple	multiple	ADJ
bibechana-29750	5	8	campus	campus	NOUN
bibechana-29750	5	9	,	,	PUNCT
bibechana-29750	5	10	tribhuvan	tribhuvan	PROPN
bibechana-29750	5	11	university	university	PROPN
bibechana-29750	5	12	,	,	PUNCT
bibechana-29750	5	13	nepal	nepal	ADJ
bibechana-29750	5	14	2central	2central	NUM
bibechana-29750	5	15	department	department	NOUN
bibechana-29750	5	16	of	of	ADP
bibechana-29750	5	17	physics	physics	PROPN
bibechana-29750	5	18	,	,	PUNCT
bibechana-29750	5	19	tribhuvan	tribhuvan	PROPN
bibechana-29750	5	20	university	university	PROPN
bibechana-29750	5	21	,	,	PUNCT
bibechana-29750	5	22	kirtipur	kirtipur	NOUN
bibechana-29750	5	23	kathmandu	kathmandu	NOUN
bibechana-29750	5	24	,	,	PUNCT
bibechana-29750	5	25	nepal	nepal	NOUN
bibechana-29750	5	26	*	*	NOUN
bibechana-29750	5	27	email	email	NOUN
bibechana-29750	5	28	:	:	PUNCT
bibechana-29750	5	29	narayan.adhikari@cdp.tu.edu.np	narayan.adhikari@cdp.tu.edu.np	ADJ
bibechana-29750	5	30	article	article	NOUN
bibechana-29750	5	31	information	information	NOUN
bibechana-29750	5	32	:	:	PUNCT
bibechana-29750	5	33	received	receive	VERB
bibechana-29750	5	34	:	:	PUNCT
bibechana-29750	5	35	june	june	PROPN
bibechana-29750	5	36	29	29	NUM
bibechana-29750	5	37	,	,	PUNCT
bibechana-29750	5	38	2020	2020	NUM
bibechana-29750	5	39	accepted	accept	VERB
bibechana-29750	5	40	:	:	PUNCT
bibechana-29750	5	41	august	august	PROPN
bibechana-29750	5	42	2	2	NUM
bibechana-29750	5	43	,	,	PUNCT
bibechana-29750	5	44	2020	2020	NUM
bibechana-29750	5	45	keywords	keyword	NOUN
bibechana-29750	5	46	:	:	PUNCT
bibechana-29750	5	47	thermodynamic	thermodynamic	ADJ
bibechana-29750	5	48	properties	property	NOUN
bibechana-29750	5	49	sickle	sickle	VERB
bibechana-29750	5	50	cell	cell	NOUN
bibechana-29750	5	51	molecular	molecular	ADJ
bibechana-29750	5	52	dynamics	dynamic	NOUN
bibechana-29750	5	53	hemoglobin	hemoglobin	NOUN
bibechana-29750	5	54	protein	protein	NOUN
bibechana-29750	5	55	abstract	abstract	ADJ
bibechana-29750	5	56	thermodynamic	thermodynamic	ADJ
bibechana-29750	5	57	properties	property	NOUN
bibechana-29750	5	58	of	of	ADP
bibechana-29750	5	59	sickled	sickled	ADJ
bibechana-29750	5	60	and	and	CCONJ
bibechana-29750	5	61	normal	normal	ADJ
bibechana-29750	5	62	hemoglobin	hemoglobin	NOUN
bibechana-29750	5	63	protein	protein	NOUN
bibechana-29750	5	64	are	be	AUX
bibechana-29750	5	65	considered	consider	VERB
bibechana-29750	5	66	within	within	ADP
bibechana-29750	5	67	the	the	DET
bibechana-29750	5	68	framework	framework	NOUN
bibechana-29750	5	69	of	of	ADP
bibechana-29750	5	70	classical	classical	ADJ
bibechana-29750	5	71	molecular	molecular	ADJ
bibechana-29750	5	72	dynamics	dynamic	NOUN
bibechana-29750	5	73	.	.	PUNCT
bibechana-29750	6	1	here	here	ADV
bibechana-29750	6	2	we	we	PRON
bibechana-29750	6	3	have	have	AUX
bibechana-29750	6	4	studied	study	VERB
bibechana-29750	6	5	the	the	DET
bibechana-29750	6	6	specific	specific	ADJ
bibechana-29750	6	7	heat	heat	NOUN
bibechana-29750	6	8	capacity	capacity	NOUN
bibechana-29750	6	9	and	and	CCONJ
bibechana-29750	6	10	rmsd	rmsd	X
bibechana-29750	6	11	(	(	PUNCT
bibechana-29750	6	12	root	root	NOUN
bibechana-29750	6	13	mean	mean	ADJ
bibechana-29750	6	14	square	square	ADJ
bibechana-29750	6	15	deviation	deviation	NOUN
bibechana-29750	6	16	)	)	PUNCT
bibechana-29750	6	17	of	of	ADP
bibechana-29750	6	18	both	both	DET
bibechana-29750	6	19	types	type	NOUN
bibechana-29750	6	20	of	of	ADP
bibechana-29750	6	21	hemoglobin	hemoglobin	NOUN
bibechana-29750	6	22	protein	protein	NOUN
bibechana-29750	6	23	.	.	PUNCT
bibechana-29750	7	1	our	our	PRON
bibechana-29750	7	2	investigation	investigation	NOUN
bibechana-29750	7	3	reveals	reveal	VERB
bibechana-29750	7	4	that	that	SCONJ
bibechana-29750	7	5	the	the	DET
bibechana-29750	7	6	specific	specific	ADJ
bibechana-29750	7	7	heat	heat	NOUN
bibechana-29750	7	8	capacity	capacity	NOUN
bibechana-29750	7	9	and	and	CCONJ
bibechana-29750	7	10	rmsd	rmsd	VERB
bibechana-29750	7	11	for	for	ADP
bibechana-29750	7	12	oxygenated	oxygenated	ADJ
bibechana-29750	7	13	hemoglobin	hemoglobin	NOUN
bibechana-29750	7	14	protein	protein	NOUN
bibechana-29750	7	15	is	be	AUX
bibechana-29750	7	16	higher	high	ADJ
bibechana-29750	7	17	than	than	ADP
bibechana-29750	7	18	those	those	PRON
bibechana-29750	7	19	of	of	ADP
bibechana-29750	7	20	de	de	ADJ
bibechana-29750	7	21	-	-	ADJ
bibechana-29750	7	22	oxygenated	oxygenated	ADJ
bibechana-29750	7	23	sickle	sickle	NOUN
bibechana-29750	7	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	7	25	protein	protein	NOUN
bibechana-29750	7	26	.	.	PUNCT
bibechana-29750	8	1	it	it	PRON
bibechana-29750	8	2	is	be	AUX
bibechana-29750	8	3	also	also	ADV
bibechana-29750	8	4	observed	observe	VERB
bibechana-29750	8	5	that	that	SCONJ
bibechana-29750	8	6	the	the	DET
bibechana-29750	8	7	specific	specific	ADJ
bibechana-29750	8	8	heat	heat	NOUN
bibechana-29750	8	9	capacity	capacity	NOUN
bibechana-29750	8	10	and	and	CCONJ
bibechana-29750	8	11	rmsd	rmsd	VERB
bibechana-29750	8	12	values	value	NOUN
bibechana-29750	8	13	of	of	ADP
bibechana-29750	8	14	sickle	sickle	NOUN
bibechana-29750	8	15	hemoglobin	hemoglobin	NOUN
bibechana-29750	8	16	protein	protein	NOUN
bibechana-29750	8	17	decrease	decrease	NOUN
bibechana-29750	8	18	with	with	ADP
bibechana-29750	8	19	rise	rise	NOUN
bibechana-29750	8	20	in	in	ADP
bibechana-29750	8	21	temperature	temperature	NOUN
bibechana-29750	8	22	.	.	PUNCT
bibechana-29750	9	1	doi	doi	NOUN
bibechana-29750	9	2	:	:	PUNCT
bibechana-29750	9	3	https://doi.org/10.3126/bibechana.v18i1.29750	https://doi.org/10.3126/bibechana.v18i1.29750	X
bibechana-29750	9	4	this	this	DET
bibechana-29750	9	5	work	work	NOUN
bibechana-29750	9	6	is	be	AUX
bibechana-29750	9	7	licensed	license	VERB
bibechana-29750	9	8	under	under	ADP
bibechana-29750	9	9	the	the	DET
bibechana-29750	9	10	creative	creative	ADJ
bibechana-29750	9	11	commons	common	NOUN
bibechana-29750	9	12	cc	cc	ADP
bibechana-29750	9	13	by	by	ADP
bibechana-29750	9	14	-	-	PUNCT
bibechana-29750	9	15	nc	nc	NOUN
bibechana-29750	9	16	license	license	NOUN
bibechana-29750	9	17	.	.	PUNCT
bibechana-29750	10	1	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	DET
bibechana-29750	10	2	1	1	NUM
bibechana-29750	10	3	.	.	PUNCT
bibechana-29750	10	4	introduction	introduction	NOUN
bibechana-29750	10	5	hemoglobin	hemoglobin	NOUN
bibechana-29750	10	6	is	be	AUX
bibechana-29750	10	7	the	the	DET
bibechana-29750	10	8	blood	blood	NOUN
bibechana-29750	10	9	component	component	NOUN
bibechana-29750	10	10	consisting	consist	VERB
bibechana-29750	10	11	of	of	ADP
bibechana-29750	10	12	heme	heme	NOUN
bibechana-29750	10	13	and	and	CCONJ
bibechana-29750	10	14	globin	globin	NOUN
bibechana-29750	10	15	,	,	PUNCT
bibechana-29750	10	16	where	where	SCONJ
bibechana-29750	10	17	heme	heme	NOUN
bibechana-29750	10	18	is	be	AUX
bibechana-29750	10	19	the	the	DET
bibechana-29750	10	20	prothestic	prothestic	ADJ
bibechana-29750	10	21	group	group	NOUN
bibechana-29750	10	22	containing	contain	VERB
bibechana-29750	10	23	iron	iron	NOUN
bibechana-29750	10	24	and	and	CCONJ
bibechana-29750	10	25	globin	globin	NOUN
bibechana-29750	10	26	is	be	AUX
bibechana-29750	10	27	the	the	DET
bibechana-29750	10	28	protein	protein	NOUN
bibechana-29750	10	29	compound	compound	NOUN
bibechana-29750	10	30	.	.	PUNCT
bibechana-29750	11	1	it	it	PRON
bibechana-29750	11	2	is	be	AUX
bibechana-29750	11	3	responsible	responsible	ADJ
bibechana-29750	11	4	for	for	ADP
bibechana-29750	11	5	the	the	DET
bibechana-29750	11	6	transportation	transportation	NOUN
bibechana-29750	11	7	of	of	ADP
bibechana-29750	11	8	oxygen	oxygen	NOUN
bibechana-29750	11	9	throughout	throughout	ADP
bibechana-29750	11	10	the	the	DET
bibechana-29750	11	11	human	human	ADJ
bibechana-29750	11	12	body	body	NOUN
bibechana-29750	11	13	.	.	PUNCT
bibechana-29750	12	1	heme	heme	NOUN
bibechana-29750	12	2	is	be	AUX
bibechana-29750	12	3	synthesized	synthesize	VERB
bibechana-29750	12	4	by	by	ADP
bibechana-29750	12	5	mitochondrion	mitochondrion	NOUN
bibechana-29750	12	6	which	which	PRON
bibechana-29750	12	7	is	be	AUX
bibechana-29750	12	8	fixed	fix	VERB
bibechana-29750	12	9	with	with	ADP
bibechana-29750	12	10	iron	iron	NOUN
bibechana-29750	12	11	.	.	PUNCT
bibechana-29750	13	1	heme	heme	NOUN
bibechana-29750	13	2	is	be	AUX
bibechana-29750	13	3	protected	protect	VERB
bibechana-29750	13	4	by	by	ADP
bibechana-29750	13	5	the	the	DET
bibechana-29750	13	6	surrounded	surround	VERB
bibechana-29750	13	7	globin	globin	NOUN
bibechana-29750	13	8	protein	protein	NOUN
bibechana-29750	13	9	.	.	PUNCT
bibechana-29750	14	1	each	each	DET
bibechana-29750	14	2	single	single	ADJ
bibechana-29750	14	3	hemoglobin	hemoglobin	NOUN
bibechana-29750	14	4	molecule	molecule	NOUN
bibechana-29750	14	5	has	have	VERB
bibechana-29750	14	6	two	two	NUM
bibechana-29750	14	7	globin	globin	NOUN
bibechana-29750	14	8	chains	chain	NOUN
bibechana-29750	14	9	,	,	PUNCT
bibechana-29750	14	10	one	one	NUM
bibechana-29750	14	11	globin	globin	NOUN
bibechana-29750	14	12	chain	chain	NOUN
bibechana-29750	14	13	is	be	AUX
bibechana-29750	14	14	α	α	PROPN
bibechana-29750	14	15	and	and	CCONJ
bibechana-29750	14	16	the	the	DET
bibechana-29750	14	17	other	other	ADJ
bibechana-29750	14	18	is	be	AUX
bibechana-29750	14	19	β	β	X
bibechana-29750	14	20	.	.	PUNCT
bibechana-29750	15	1	two	two	NUM
bibechana-29750	15	2	hemoglobin	hemoglobin	NOUN
bibechana-29750	15	3	molecules	molecule	NOUN
bibechana-29750	15	4	combine	combine	VERB
bibechana-29750	15	5	to	to	PART
bibechana-29750	15	6	produce	produce	VERB
bibechana-29750	15	7	a	a	DET
bibechana-29750	15	8	functional	functional	ADJ
bibechana-29750	15	9	tetramer	tetramer	NOUN
bibechana-29750	15	10	.	.	PUNCT
bibechana-29750	16	1	in	in	ADP
bibechana-29750	16	2	inherited	inherited	ADJ
bibechana-29750	16	3	hemoglobin	hemoglobin	NOUN
bibechana-29750	16	4	the	the	DET
bibechana-29750	16	5	amino	amino	NOUN
bibechana-29750	16	6	acid	acid	NOUN
bibechana-29750	16	7	sequence	sequence	NOUN
bibechana-29750	16	8	is	be	AUX
bibechana-29750	16	9	changed	change	VERB
bibechana-29750	16	10	because	because	SCONJ
bibechana-29750	16	11	of	of	ADP
bibechana-29750	16	12	the	the	DET
bibechana-29750	16	13	incorrect	incorrect	ADJ
bibechana-29750	16	14	dna	dna	PROPN
bibechana-29750	16	15	code	code	NOUN
bibechana-29750	16	16	(	(	PUNCT
bibechana-29750	16	17	hbs	hbs	PROPN
bibechana-29750	16	18	)	)	PUNCT
bibechana-29750	16	19	.	.	PUNCT
bibechana-29750	17	1	such	such	DET
bibechana-29750	17	2	a	a	DET
bibechana-29750	17	3	cell	cell	NOUN
bibechana-29750	17	4	having	have	VERB
bibechana-29750	17	5	abnormality	abnormality	NOUN
bibechana-29750	17	6	is	be	AUX
bibechana-29750	17	7	a	a	DET
bibechana-29750	17	8	sickle	sickle	NOUN
bibechana-29750	17	9	cell	cell	NOUN
bibechana-29750	17	10	.	.	PUNCT
bibechana-29750	18	1	sickle	sickle	NOUN
bibechana-29750	18	2	cell	cell	NOUN
bibechana-29750	18	3	disease	disease	NOUN
bibechana-29750	18	4	is	be	AUX
bibechana-29750	18	5	the	the	DET
bibechana-29750	18	6	genetic	genetic	ADJ
bibechana-29750	18	7	disorder	disorder	NOUN
bibechana-29750	18	8	in	in	ADP
bibechana-29750	18	9	which	which	PRON
bibechana-29750	18	10	sudden	sudden	ADJ
bibechana-29750	18	11	change	change	NOUN
bibechana-29750	18	12	of	of	ADP
bibechana-29750	18	13	hemoglobin	hemoglobin	NOUN
bibechana-29750	18	14	protein	protein	NOUN
bibechana-29750	18	15	occurs	occur	VERB
bibechana-29750	18	16	.	.	PUNCT
bibechana-29750	19	1	the	the	DET
bibechana-29750	19	2	glutamic	glutamic	ADJ
bibechana-29750	19	3	acid	acid	NOUN
bibechana-29750	19	4	of	of	ADP
bibechana-29750	19	5	both	both	CCONJ
bibechana-29750	19	6	the	the	DET
bibechana-29750	19	7	β	β	PROPN
bibechana-29750	19	8	chain	chain	NOUN
bibechana-29750	19	9	in	in	ADP
bibechana-29750	19	10	the	the	DET
bibechana-29750	19	11	sixth	sixth	ADJ
bibechana-29750	19	12	position	position	NOUN
bibechana-29750	19	13	of	of	ADP
bibechana-29750	19	14	normal	normal	ADJ
bibechana-29750	19	15	hemoglobin	hemoglobin	NOUN
bibechana-29750	19	16	protein	protein	NOUN
bibechana-29750	19	17	is	be	AUX
bibechana-29750	19	18	replaced	replace	VERB
bibechana-29750	19	19	by	by	ADP
bibechana-29750	19	20	valine	valine	NOUN
bibechana-29750	19	21	in	in	ADP
bibechana-29750	19	22	the	the	DET
bibechana-29750	19	23	sickle	sickle	NOUN
bibechana-29750	19	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	19	25	which	which	PRON
bibechana-29750	19	26	is	be	AUX
bibechana-29750	19	27	shown	show	VERB
bibechana-29750	19	28	in	in	ADP
bibechana-29750	19	29	figure	figure	NOUN
bibechana-29750	19	30	1	1	NUM
bibechana-29750	19	31	.	.	PUNCT
bibechana-29750	20	1	as	as	ADP
bibechana-29750	20	2	a	a	DET
bibechana-29750	20	3	result	result	NOUN
bibechana-29750	20	4	rbc	rbc	PROPN
bibechana-29750	20	5	changes	change	NOUN
bibechana-29750	20	6	from	from	ADP
bibechana-29750	20	7	flexible	flexible	ADJ
bibechana-29750	20	8	bi	bi	NOUN
bibechana-29750	20	9	-	-	ADJ
bibechana-29750	20	10	concave	concave	ADJ
bibechana-29750	20	11	to	to	ADP
bibechana-29750	20	12	strong	strong	ADJ
bibechana-29750	20	13	elongated	elongate	VERB
bibechana-29750	20	14	shape	shape	NOUN
bibechana-29750	20	15	.	.	PUNCT
bibechana-29750	21	1	thus	thus	ADV
bibechana-29750	21	2	by	by	ADP
bibechana-29750	21	3	carrying	carry	VERB
bibechana-29750	21	4	less	less	ADJ
bibechana-29750	21	5	oxygen	oxygen	NOUN
bibechana-29750	21	6	,	,	PUNCT
bibechana-29750	21	7	the	the	DET
bibechana-29750	21	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	21	9	becomes	become	VERB
bibechana-29750	21	10	fibrous	fibrous	ADJ
bibechana-29750	21	11	aggregations	aggregation	NOUN
bibechana-29750	21	12	giving	give	VERB
bibechana-29750	21	13	the	the	DET
bibechana-29750	21	14	entire	entire	ADJ
bibechana-29750	21	15	red	red	ADJ
bibechana-29750	21	16	blood	blood	NOUN
bibechana-29750	21	17	cell	cell	NOUN
bibechana-29750	21	18	a	a	DET
bibechana-29750	21	19	sickle	sickle	NOUN
bibechana-29750	21	20	shape	shape	NOUN
bibechana-29750	21	21	.	.	PUNCT
bibechana-29750	22	1	sickled	sickled	ADJ
bibechana-29750	22	2	hemoglobin	hemoglobin	NOUN
bibechana-29750	22	3	protein	protein	NOUN
bibechana-29750	22	4	(	(	PUNCT
bibechana-29750	22	5	hbs	hbs	PROPN
bibechana-29750	22	6	)	)	PUNCT
bibechana-29750	22	7	damages	damage	VERB
bibechana-29750	22	8	the	the	DET
bibechana-29750	22	9	sickle	sickle	NOUN
bibechana-29750	22	10	erythrocyte	erythrocyte	NOUN
bibechana-29750	22	11	and	and	CCONJ
bibechana-29750	22	12	causes	cause	VERB
bibechana-29750	22	13	the	the	DET
bibechana-29750	22	14	increase	increase	NOUN
bibechana-29750	22	15	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-29750	22	16	mailto:narayan.adhikari@cdp.tu.edu.np	mailto:narayan.adhikari@cdp.tu.edu.np	PROPN
bibechana-29750	22	17	mailto:ari@cdp.tu.edu.np	mailto:ari@cdp.tu.edu.np	PROPN
bibechana-29750	22	18	https://doi.org/10.3126/bibechana.v18i1.29750	https://doi.org/10.3126/bibechana.v18i1.29750	X
bibechana-29750	22	19	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
bibechana-29750	22	20	jhulan	jhulan	PROPN
bibechana-29750	22	21	powrel	powrel	NOUN
bibechana-29750	22	22	,	,	PUNCT
bibechana-29750	22	23	narayan	narayan	PROPN
bibechana-29750	23	1	p.	p.	NOUN
bibechana-29750	23	2	adhikari/	adhikari/	NUM
bibechana-29750	23	3	bibechana	bibechana	NOUN
bibechana-29750	23	4	18	18	NUM
bibechana-29750	23	5	(	(	PUNCT
bibechana-29750	23	6	1)(2021	1)(2021	NUM
bibechana-29750	23	7	)	)	PUNCT
bibechana-29750	23	8	140	140	NUM
bibechana-29750	23	9	-	-	SYM
bibechana-29750	23	10	148	148	NUM
bibechana-29750	23	11	141	141	NUM
bibechana-29750	23	12	in	in	ADP
bibechana-29750	23	13	the	the	DET
bibechana-29750	23	14	density	density	NOUN
bibechana-29750	23	15	,	,	PUNCT
bibechana-29750	23	16	reduction	reduction	NOUN
bibechana-29750	23	17	in	in	ADP
bibechana-29750	23	18	the	the	DET
bibechana-29750	23	19	deformability	deformability	NOUN
bibechana-29750	23	20	and	and	CCONJ
bibechana-29750	23	21	increase	increase	VERB
bibechana-29750	23	22	in	in	ADP
bibechana-29750	23	23	the	the	DET
bibechana-29750	23	24	adhesivity	adhesivity	NOUN
bibechana-29750	23	25	which	which	PRON
bibechana-29750	23	26	shortens	shorten	VERB
bibechana-29750	23	27	the	the	DET
bibechana-29750	23	28	life	life	NOUN
bibechana-29750	23	29	span	span	NOUN
bibechana-29750	24	1	[	[	X
bibechana-29750	24	2	1	1	NUM
bibechana-29750	24	3	-	-	SYM
bibechana-29750	24	4	3	3	NUM
bibechana-29750	24	5	]	]	PUNCT
bibechana-29750	24	6	.	.	PUNCT
bibechana-29750	25	1	the	the	DET
bibechana-29750	25	2	polymerization	polymerization	NOUN
bibechana-29750	25	3	of	of	ADP
bibechana-29750	25	4	deoxygenated	deoxygenate	VERB
bibechana-29750	25	5	hemoglobin	hemoglobin	NOUN
bibechana-29750	25	6	(	(	PUNCT
bibechana-29750	25	7	hbs	hbs	PROPN
bibechana-29750	25	8	)	)	PUNCT
bibechana-29750	25	9	is	be	AUX
bibechana-29750	25	10	the	the	DET
bibechana-29750	25	11	primary	primary	ADJ
bibechana-29750	25	12	and	and	CCONJ
bibechana-29750	25	13	indispensable	indispensable	ADJ
bibechana-29750	25	14	event	event	NOUN
bibechana-29750	25	15	in	in	ADP
bibechana-29750	25	16	the	the	DET
bibechana-29750	25	17	molecular	molecular	ADJ
bibechana-29750	25	18	pathogenesis	pathogenesis	NOUN
bibechana-29750	25	19	of	of	ADP
bibechana-29750	25	20	sickle	sickle	NOUN
bibechana-29750	25	21	cell	cell	NOUN
bibechana-29750	25	22	disease	disease	NOUN
bibechana-29750	25	23	.	.	PUNCT
bibechana-29750	26	1	there	there	PRON
bibechana-29750	26	2	are	be	VERB
bibechana-29750	26	3	many	many	ADJ
bibechana-29750	26	4	symptoms	symptom	NOUN
bibechana-29750	26	5	like	like	ADP
bibechana-29750	26	6	the	the	DET
bibechana-29750	26	7	attacks	attack	NOUN
bibechana-29750	26	8	of	of	ADP
bibechana-29750	26	9	pain	pain	NOUN
bibechana-29750	26	10	,	,	PUNCT
bibechana-29750	26	11	sickle	sickle	NOUN
bibechana-29750	26	12	cell	cell	NOUN
bibechana-29750	26	13	anemia	anemia	NOUN
bibechana-29750	26	14	,	,	PUNCT
bibechana-29750	26	15	swelling	swell	VERB
bibechana-29750	26	16	in	in	ADP
bibechana-29750	26	17	the	the	DET
bibechana-29750	26	18	hands	hand	NOUN
bibechana-29750	26	19	and	and	CCONJ
bibechana-29750	26	20	feet	foot	NOUN
bibechana-29750	26	21	,	,	PUNCT
bibechana-29750	26	22	bacterial	bacterial	ADJ
bibechana-29750	26	23	infections	infection	NOUN
bibechana-29750	26	24	and	and	CCONJ
bibechana-29750	26	25	stroke	stroke	NOUN
bibechana-29750	26	26	.	.	PUNCT
bibechana-29750	27	1	longterm	longterm	PROPN
bibechana-29750	27	2	pain	pain	NOUN
bibechana-29750	27	3	may	may	AUX
bibechana-29750	27	4	develop	develop	VERB
bibechana-29750	27	5	as	as	SCONJ
bibechana-29750	27	6	people	people	NOUN
bibechana-29750	27	7	get	get	VERB
bibechana-29750	27	8	older	old	ADJ
bibechana-29750	27	9	because	because	SCONJ
bibechana-29750	27	10	of	of	ADP
bibechana-29750	27	11	sickle	sickle	NOUN
bibechana-29750	27	12	cell	cell	NOUN
bibechana-29750	27	13	anemia	anemia	NOUN
bibechana-29750	27	14	.	.	PUNCT
bibechana-29750	28	1	on	on	ADP
bibechana-29750	28	2	the	the	DET
bibechana-29750	28	3	other	other	ADJ
bibechana-29750	28	4	hand	hand	NOUN
bibechana-29750	28	5	,	,	PUNCT
bibechana-29750	28	6	heterozygote	heterozygote	NOUN
bibechana-29750	28	7	for	for	ADP
bibechana-29750	28	8	the	the	DET
bibechana-29750	28	9	sickle	sickle	NOUN
bibechana-29750	28	10	gene	gene	NOUN
bibechana-29750	28	11	are	be	AUX
bibechana-29750	28	12	relatively	relatively	ADV
bibechana-29750	28	13	protected	protect	VERB
bibechana-29750	28	14	against	against	ADP
bibechana-29750	28	15	the	the	DET
bibechana-29750	28	16	danger	danger	NOUN
bibechana-29750	28	17	of	of	ADP
bibechana-29750	28	18	dying	die	VERB
bibechana-29750	28	19	by	by	ADP
bibechana-29750	28	20	malaria	malaria	NOUN
bibechana-29750	28	21	,	,	PUNCT
bibechana-29750	28	22	as	as	SCONJ
bibechana-29750	28	23	now	now	ADV
bibechana-29750	28	24	firmly	firmly	ADV
bibechana-29750	28	25	established	establish	VERB
bibechana-29750	28	26	through	through	ADP
bibechana-29750	28	27	a	a	DET
bibechana-29750	28	28	number	number	NOUN
bibechana-29750	28	29	of	of	ADP
bibechana-29750	28	30	clinical	clinical	ADJ
bibechana-29750	28	31	field	field	NOUN
bibechana-29750	28	32	studies	study	NOUN
bibechana-29750	28	33	from	from	ADP
bibechana-29750	28	34	different	different	ADJ
bibechana-29750	28	35	parts	part	NOUN
bibechana-29750	28	36	of	of	ADP
bibechana-29750	28	37	africa	africa	PROPN
bibechana-29750	28	38	and	and	CCONJ
bibechana-29750	28	39	asia(terai	asia(terai	PROPN
bibechana-29750	28	40	region	region	NOUN
bibechana-29750	28	41	of	of	ADP
bibechana-29750	28	42	nepal)[4	nepal)[4	NUM
bibechana-29750	28	43	]	]	PUNCT
bibechana-29750	28	44	.	.	PUNCT
bibechana-29750	29	1	figure	figure	VERB
bibechana-29750	29	2	2(a	2(a	NUM
bibechana-29750	29	3	)	)	PUNCT
bibechana-29750	30	1	shows	show	VERB
bibechana-29750	30	2	the	the	DET
bibechana-29750	30	3	glutamate	glutamate	NOUN
bibechana-29750	30	4	6	6	NUM
bibechana-29750	30	5	of	of	ADP
bibechana-29750	30	6	α	α	PRON
bibechana-29750	30	7	chain	chain	NOUN
bibechana-29750	30	8	in	in	ADP
bibechana-29750	30	9	hemoglobin	hemoglobin	NOUN
bibechana-29750	30	10	protein	protein	NOUN
bibechana-29750	30	11	which	which	PRON
bibechana-29750	30	12	is	be	AUX
bibechana-29750	30	13	undergoes	undergo	VERB
bibechana-29750	30	14	a	a	DET
bibechana-29750	30	15	mutation	mutation	NOUN
bibechana-29750	30	16	to	to	ADP
bibechana-29750	30	17	valine	valine	NOUN
bibechana-29750	30	18	.	.	PUNCT
bibechana-29750	31	1	this	this	DET
bibechana-29750	31	2	mutation	mutation	NOUN
bibechana-29750	31	3	changes	change	VERB
bibechana-29750	31	4	the	the	DET
bibechana-29750	31	5	charge	charge	NOUN
bibechana-29750	31	6	on	on	ADP
bibechana-29750	31	7	the	the	DET
bibechana-29750	31	8	surface	surface	NOUN
bibechana-29750	31	9	of	of	ADP
bibechana-29750	31	10	hemoglobin	hemoglobin	NOUN
bibechana-29750	31	11	.	.	PUNCT
bibechana-29750	32	1	the	the	DET
bibechana-29750	32	2	mutant	mutant	ADJ
bibechana-29750	32	3	protein	protein	NOUN
bibechana-29750	32	4	is	be	AUX
bibechana-29750	32	5	called	call	VERB
bibechana-29750	32	6	sickle	sickle	NOUN
bibechana-29750	32	7	cell	cell	NOUN
bibechana-29750	32	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	32	9	(	(	PUNCT
bibechana-29750	32	10	hbs	hbs	PROPN
bibechana-29750	32	11	)	)	PUNCT
bibechana-29750	32	12	.	.	PUNCT
bibechana-29750	33	1	valine	valine	NOUN
bibechana-29750	33	2	residue	residue	NOUN
bibechana-29750	33	3	6	6	NUM
bibechana-29750	33	4	of	of	ADP
bibechana-29750	33	5	the	the	DET
bibechana-29750	33	6	β	β	X
bibechana-29750	33	7	chain	chain	NOUN
bibechana-29750	33	8	of	of	ADP
bibechana-29750	33	9	deoxy	deoxy	PROPN
bibechana-29750	33	10	-	-	PUNCT
bibechana-29750	33	11	hbs	hbs	PROPN
bibechana-29750	33	12	lies	lie	VERB
bibechana-29750	33	13	on	on	ADP
bibechana-29750	33	14	the	the	DET
bibechana-29750	33	15	surface	surface	NOUN
bibechana-29750	33	16	of	of	ADP
bibechana-29750	33	17	the	the	DET
bibechana-29750	33	18	protein	protein	NOUN
bibechana-29750	33	19	.	.	PUNCT
bibechana-29750	34	1	this	this	DET
bibechana-29750	34	2	hydrophobic	hydrophobic	NOUN
bibechana-29750	34	3	residue	residue	NOUN
bibechana-29750	34	4	,	,	PUNCT
bibechana-29750	34	5	present	present	ADJ
bibechana-29750	34	6	in	in	ADP
bibechana-29750	34	7	each	each	PRON
bibechana-29750	34	8	of	of	ADP
bibechana-29750	34	9	the	the	DET
bibechana-29750	34	10	β	β	PROPN
bibechana-29750	34	11	chain	chain	NOUN
bibechana-29750	34	12	,	,	PUNCT
bibechana-29750	34	13	forms	form	VERB
bibechana-29750	34	14	a	a	DET
bibechana-29750	34	15	hydrophobic	hydrophobic	NOUN
bibechana-29750	34	16	contact	contact	NOUN
bibechana-29750	34	17	in	in	ADP
bibechana-29750	34	18	the	the	DET
bibechana-29750	34	19	neighboring	neighboring	NOUN
bibechana-29750	34	20	β	β	NOUN
bibechana-29750	34	21	chain	chain	NOUN
bibechana-29750	34	22	of	of	ADP
bibechana-29750	34	23	another	another	DET
bibechana-29750	34	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	34	25	molecule	molecule	NOUN
bibechana-29750	34	26	[	[	X
bibechana-29750	34	27	1	1	NUM
bibechana-29750	34	28	,	,	PUNCT
bibechana-29750	34	29	6	6	NUM
bibechana-29750	34	30	]	]	PUNCT
bibechana-29750	34	31	.	.	PUNCT
bibechana-29750	35	1	figure	figure	NOUN
bibechana-29750	35	2	2(b	2(b	NUM
bibechana-29750	35	3	)	)	PUNCT
bibechana-29750	35	4	shows	show	VERB
bibechana-29750	35	5	the	the	DET
bibechana-29750	35	6	mutation	mutation	NOUN
bibechana-29750	35	7	that	that	PRON
bibechana-29750	35	8	replaces	replace	VERB
bibechana-29750	35	9	a	a	DET
bibechana-29750	35	10	glutamate	glutamate	ADJ
bibechana-29750	35	11	residue	residue	NOUN
bibechana-29750	35	12	by	by	ADP
bibechana-29750	35	13	a	a	DET
bibechana-29750	35	14	valine	valine	NOUN
bibechana-29750	35	15	residue	residue	NOUN
bibechana-29750	35	16	which	which	PRON
bibechana-29750	35	17	reduced	reduce	VERB
bibechana-29750	35	18	the	the	DET
bibechana-29750	35	19	solubility	solubility	NOUN
bibechana-29750	35	20	of	of	ADP
bibechana-29750	35	21	the	the	DET
bibechana-29750	35	22	protein	protein	NOUN
bibechana-29750	35	23	.	.	PUNCT
bibechana-29750	36	1	luzzatto	luzzatto	PROPN
bibechana-29750	36	2	l.	l.	PROPN
bibechana-29750	36	3	studied	study	VERB
bibechana-29750	36	4	the	the	DET
bibechana-29750	36	5	structural	structural	ADJ
bibechana-29750	36	6	abnormality	abnormality	NOUN
bibechana-29750	36	7	of	of	ADP
bibechana-29750	36	8	sickle	sickle	NOUN
bibechana-29750	36	9	hemoglobin	hemoglobin	NOUN
bibechana-29750	36	10	(	(	PUNCT
bibechana-29750	36	11	hbs	hbs	PROPN
bibechana-29750	36	12	)	)	PUNCT
bibechana-29750	36	13	and	and	CCONJ
bibechana-29750	36	14	noticed	notice	VERB
bibechana-29750	36	15	as	as	SCONJ
bibechana-29750	36	16	this	this	PRON
bibechana-29750	36	17	was	be	AUX
bibechana-29750	36	18	the	the	DET
bibechana-29750	36	19	first	first	ADJ
bibechana-29750	36	20	time	time	NOUN
bibechana-29750	36	21	that	that	PRON
bibechana-29750	36	22	a	a	DET
bibechana-29750	36	23	single	single	ADJ
bibechana-29750	36	24	amino	amino	NOUN
bibechana-29750	36	25	acid	acid	NOUN
bibechana-29750	36	26	replacement	replacement	NOUN
bibechana-29750	36	27	in	in	ADP
bibechana-29750	36	28	a	a	DET
bibechana-29750	36	29	protein	protein	NOUN
bibechana-29750	36	30	causes	cause	VERB
bibechana-29750	36	31	a	a	DET
bibechana-29750	36	32	serious	serious	ADJ
bibechana-29750	36	33	disease	disease	NOUN
bibechana-29750	36	34	[	[	X
bibechana-29750	36	35	7	7	NUM
bibechana-29750	36	36	]	]	PUNCT
bibechana-29750	36	37	.	.	PUNCT
bibechana-29750	37	1	a	a	DET
bibechana-29750	37	2	group	group	NOUN
bibechana-29750	37	3	of	of	ADP
bibechana-29750	37	4	scientists	scientist	NOUN
bibechana-29750	37	5	,	,	PUNCT
bibechana-29750	37	6	stradner	stradner	NOUN
bibechana-29750	37	7	and	and	CCONJ
bibechana-29750	37	8	fig	fig	NOUN
bibechana-29750	37	9	.	.	PUNCT
bibechana-29750	38	1	1	1	NUM
bibechana-29750	38	2	:	:	PUNCT
bibechana-29750	38	3	normal	normal	ADJ
bibechana-29750	38	4	(	(	PUNCT
bibechana-29750	38	5	glu	glu	PROPN
bibechana-29750	38	6	)	)	PUNCT
bibechana-29750	38	7	and	and	CCONJ
bibechana-29750	38	8	sickle	sickle	NOUN
bibechana-29750	38	9	cell	cell	NOUN
bibechana-29750	38	10	(	(	PUNCT
bibechana-29750	38	11	val	val	NOUN
bibechana-29750	38	12	)	)	PUNCT
bibechana-29750	38	13	hemoglobin	hemoglobin	NOUN
bibechana-29750	39	1	[	[	X
bibechana-29750	39	2	5	5	NUM
bibechana-29750	39	3	]	]	PUNCT
bibechana-29750	39	4	.	.	PUNCT
bibechana-29750	40	1	co	co	NOUN
bibechana-29750	40	2	-	-	NOUN
bibechana-29750	40	3	worker	worker	NOUN
bibechana-29750	40	4	studied	study	VERB
bibechana-29750	40	5	molecular	molecular	ADJ
bibechana-29750	40	6	dynamical	dynamical	ADJ
bibechana-29750	40	7	simulations	simulation	NOUN
bibechana-29750	40	8	[	[	X
bibechana-29750	40	9	1	1	X
bibechana-29750	40	10	]	]	PUNCT
bibechana-29750	40	11	and	and	CCONJ
bibechana-29750	40	12	developed	develop	VERB
bibechana-29750	40	13	the	the	DET
bibechana-29750	40	14	concept	concept	NOUN
bibechana-29750	40	15	of	of	ADP
bibechana-29750	40	16	the	the	DET
bibechana-29750	40	17	study	study	NOUN
bibechana-29750	40	18	from	from	ADP
bibechana-29750	40	19	soft	soft	ADJ
bibechana-29750	40	20	matter	matter	NOUN
bibechana-29750	40	21	physics	physics	NOUN
bibechana-29750	40	22	to	to	ADP
bibechana-29750	40	23	complex	complex	ADJ
bibechana-29750	40	24	protein	protein	NOUN
bibechana-29750	40	25	mixtures	mixture	NOUN
bibechana-29750	40	26	[	[	X
bibechana-29750	40	27	8].a	8].a	NUM
bibechana-29750	40	28	potential	potential	ADJ
bibechana-29750	40	29	antisickling	antisickle	VERB
bibechana-29750	40	30	drug	drug	NOUN
bibechana-29750	40	31	is	be	AUX
bibechana-29750	40	32	still	still	ADV
bibechana-29750	40	33	to	to	PART
bibechana-29750	40	34	be	be	AUX
bibechana-29750	40	35	discovered	discover	VERB
bibechana-29750	41	1	[	[	X
bibechana-29750	41	2	9	9	NUM
bibechana-29750	41	3	]	]	PUNCT
bibechana-29750	41	4	as	as	ADP
bibechana-29750	41	5	per	per	ADP
bibechana-29750	41	6	pathophysiological	pathophysiological	ADJ
bibechana-29750	41	7	study	study	NOUN
bibechana-29750	41	8	in	in	ADP
bibechana-29750	41	9	the	the	DET
bibechana-29750	41	10	last	last	ADJ
bibechana-29750	41	11	100	100	NUM
bibechana-29750	41	12	years	year	NOUN
bibechana-29750	41	13	of	of	ADP
bibechana-29750	41	14	sickle	sickle	NOUN
bibechana-29750	41	15	cell	cell	NOUN
bibechana-29750	41	16	disease	disease	NOUN
bibechana-29750	41	17	.	.	PUNCT
bibechana-29750	42	1	another	another	DET
bibechana-29750	42	2	group	group	NOUN
bibechana-29750	42	3	,	,	PUNCT
bibechana-29750	42	4	xianqiao	xianqiao	PROPN
bibechana-29750	42	5	wang	wang	PROPN
bibechana-29750	42	6	and	and	CCONJ
bibechana-29750	42	7	rodney	rodney	PROPN
bibechana-29750	42	8	d.	d.	PROPN
bibechana-29750	42	9	developed	develop	VERB
bibechana-29750	42	10	a	a	DET
bibechana-29750	42	11	virtual	virtual	ADJ
bibechana-29750	42	12	mechanical	mechanical	ADJ
bibechana-29750	42	13	model	model	NOUN
bibechana-29750	42	14	for	for	ADP
bibechana-29750	42	15	determining	determine	VERB
bibechana-29750	42	16	the	the	DET
bibechana-29750	42	17	mechanical	mechanical	ADJ
bibechana-29750	42	18	and	and	CCONJ
bibechana-29750	42	19	thermal	thermal	ADJ
bibechana-29750	42	20	behavior	behavior	NOUN
bibechana-29750	42	21	of	of	ADP
bibechana-29750	42	22	different	different	ADJ
bibechana-29750	42	23	soft	soft	ADJ
bibechana-29750	42	24	matter	matter	NOUN
bibechana-29750	42	25	by	by	ADP
bibechana-29750	42	26	using	use	VERB
bibechana-29750	42	27	the	the	DET
bibechana-29750	42	28	steps	step	NOUN
bibechana-29750	42	29	of	of	ADP
bibechana-29750	42	30	optimization	optimization	NOUN
bibechana-29750	42	31	of	of	ADP
bibechana-29750	42	32	energy	energy	NOUN
bibechana-29750	42	33	,	,	PUNCT
bibechana-29750	42	34	making	make	VERB
bibechana-29750	42	35	of	of	ADP
bibechana-29750	42	36	equilibration	equilibration	NOUN
bibechana-29750	42	37	in	in	ADP
bibechana-29750	42	38	the	the	DET
bibechana-29750	42	39	system	system	NOUN
bibechana-29750	42	40	and	and	CCONJ
bibechana-29750	42	41	production	production	NOUN
bibechana-29750	42	42	run	run	NOUN
bibechana-29750	42	43	[	[	X
bibechana-29750	42	44	10	10	NUM
bibechana-29750	42	45	]	]	PUNCT
bibechana-29750	42	46	.	.	PUNCT
bibechana-29750	43	1	an	an	DET
bibechana-29750	43	2	electrochemistry	electrochemistry	NOUN
bibechana-29750	43	3	based	base	VERB
bibechana-29750	43	4	study	study	NOUN
bibechana-29750	43	5	designed	design	VERB
bibechana-29750	43	6	a	a	DET
bibechana-29750	43	7	technique	technique	NOUN
bibechana-29750	43	8	to	to	PART
bibechana-29750	43	9	control	control	VERB
bibechana-29750	43	10	and	and	CCONJ
bibechana-29750	43	11	monitor	monitor	VERB
bibechana-29750	43	12	the	the	DET
bibechana-29750	43	13	polymerization	polymerization	NOUN
bibechana-29750	43	14	of	of	ADP
bibechana-29750	43	15	sickle	sickle	NOUN
bibechana-29750	43	16	-	-	PUNCT
bibechana-29750	43	17	cell	cell	NOUN
bibechana-29750	43	18	hemoglobin	hemoglobin	NOUN
bibechana-29750	43	19	(	(	PUNCT
bibechana-29750	43	20	hbs	hbs	PROPN
bibechana-29750	43	21	)	)	PUNCT
bibechana-29750	43	22	by	by	ADP
bibechana-29750	43	23	looking	look	VERB
bibechana-29750	43	24	the	the	DET
bibechana-29750	43	25	change	change	NOUN
bibechana-29750	43	26	in	in	ADP
bibechana-29750	43	27	turbidity	turbidity	NOUN
bibechana-29750	43	28	during	during	ADP
bibechana-29750	43	29	the	the	DET
bibechana-29750	43	30	depletion	depletion	NOUN
bibechana-29750	43	31	of	of	ADP
bibechana-29750	43	32	oxygen	oxygen	NOUN
bibechana-29750	43	33	in	in	ADP
bibechana-29750	43	34	a	a	DET
bibechana-29750	43	35	small	small	ADJ
bibechana-29750	43	36	volume	volume	NOUN
bibechana-29750	43	37	of	of	ADP
bibechana-29750	43	38	custom	custom	ADV
bibechana-29750	43	39	-	-	PUNCT
bibechana-29750	43	40	built	build	VERB
bibechana-29750	43	41	thinlayer	thinlayer	NOUN
bibechana-29750	43	42	electrochemical	electrochemical	ADJ
bibechana-29750	43	43	cell	cell	NOUN
bibechana-29750	43	44	.	.	PUNCT
bibechana-29750	44	1	the	the	DET
bibechana-29750	44	2	cell	cell	NOUN
bibechana-29750	44	3	allowed	allow	VERB
bibechana-29750	44	4	the	the	DET
bibechana-29750	44	5	investigation	investigation	NOUN
bibechana-29750	44	6	of	of	ADP
bibechana-29750	44	7	hbs	hbs	PROPN
bibechana-29750	44	8	polymerization	polymerization	NOUN
bibechana-29750	44	9	as	as	ADP
bibechana-29750	44	10	a	a	DET
bibechana-29750	44	11	function	function	NOUN
bibechana-29750	44	12	of	of	ADP
bibechana-29750	44	13	hbs	hbs	PROPN
bibechana-29750	44	14	concentration	concentration	NOUN
bibechana-29750	44	15	,	,	PUNCT
bibechana-29750	44	16	temperature	temperature	NOUN
bibechana-29750	44	17	and	and	CCONJ
bibechana-29750	44	18	solution	solution	NOUN
bibechana-29750	44	19	ph	ph	VERB
bibechana-29750	44	20	[	[	X
bibechana-29750	44	21	11	11	NUM
bibechana-29750	44	22	]	]	PUNCT
bibechana-29750	44	23	.	.	PUNCT
bibechana-29750	45	1	due	due	ADP
bibechana-29750	45	2	to	to	ADP
bibechana-29750	45	3	bad	bad	ADJ
bibechana-29750	45	4	impact	impact	NOUN
bibechana-29750	45	5	of	of	ADP
bibechana-29750	45	6	sickle	sickle	NOUN
bibechana-29750	45	7	cell	cell	NOUN
bibechana-29750	45	8	disease	disease	NOUN
bibechana-29750	45	9	,	,	PUNCT
bibechana-29750	45	10	this	this	DET
bibechana-29750	45	11	research	research	NOUN
bibechana-29750	45	12	work	work	NOUN
bibechana-29750	45	13	got	get	VERB
bibechana-29750	45	14	attention	attention	NOUN
bibechana-29750	45	15	on	on	ADP
bibechana-29750	45	16	the	the	DET
bibechana-29750	45	17	study	study	NOUN
bibechana-29750	45	18	of	of	ADP
bibechana-29750	45	19	thermal	thermal	ADJ
bibechana-29750	45	20	and	and	CCONJ
bibechana-29750	45	21	transport	transport	NOUN
bibechana-29750	45	22	property	property	NOUN
bibechana-29750	45	23	of	of	ADP
bibechana-29750	45	24	sickle	sickle	NOUN
bibechana-29750	45	25	hemoglobin	hemoglobin	NOUN
bibechana-29750	45	26	and	and	CCONJ
bibechana-29750	45	27	normal	normal	ADJ
bibechana-29750	45	28	hemoglobin	hemoglobin	NOUN
bibechana-29750	45	29	protein	protein	NOUN
bibechana-29750	45	30	.	.	PUNCT
bibechana-29750	46	1	literature	literature	PROPN
bibechana-29750	46	2	review	review	PROPN
bibechana-29750	46	3	also	also	ADV
bibechana-29750	46	4	reveals	reveal	VERB
bibechana-29750	46	5	that	that	SCONJ
bibechana-29750	46	6	the	the	DET
bibechana-29750	46	7	mechanical	mechanical	ADJ
bibechana-29750	46	8	,	,	PUNCT
bibechana-29750	46	9	thermal	thermal	ADJ
bibechana-29750	46	10	and	and	CCONJ
bibechana-29750	46	11	transport	transport	NOUN
bibechana-29750	46	12	properties	property	NOUN
bibechana-29750	46	13	of	of	ADP
bibechana-29750	46	14	normal	normal	ADJ
bibechana-29750	46	15	hemoglobin	hemoglobin	NOUN
bibechana-29750	46	16	and	and	CCONJ
bibechana-29750	46	17	sickle	sickle	NOUN
bibechana-29750	46	18	hemoglobin	hemoglobin	NOUN
bibechana-29750	46	19	protein	protein	NOUN
bibechana-29750	46	20	around	around	ADP
bibechana-29750	46	21	human	human	ADJ
bibechana-29750	46	22	body	body	NOUN
bibechana-29750	46	23	temperature	temperature	NOUN
bibechana-29750	46	24	(	(	PUNCT
bibechana-29750	46	25	310	310	NUM
bibechana-29750	46	26	k	k	NOUN
bibechana-29750	46	27	)	)	PUNCT
bibechana-29750	46	28	are	be	AUX
bibechana-29750	46	29	not	not	PART
bibechana-29750	46	30	studied	study	VERB
bibechana-29750	46	31	yet	yet	ADV
bibechana-29750	46	32	.	.	PUNCT
bibechana-29750	47	1	the	the	DET
bibechana-29750	47	2	paper	paper	NOUN
bibechana-29750	47	3	is	be	AUX
bibechana-29750	47	4	organized	organize	VERB
bibechana-29750	47	5	with	with	ADP
bibechana-29750	47	6	methods	method	NOUN
bibechana-29750	47	7	and	and	CCONJ
bibechana-29750	47	8	methodology	methodology	NOUN
bibechana-29750	47	9	part	part	NOUN
bibechana-29750	47	10	in	in	ADP
bibechana-29750	47	11	section	section	NOUN
bibechana-29750	47	12	2	2	NUM
bibechana-29750	47	13	,	,	PUNCT
bibechana-29750	47	14	computational	computational	ADJ
bibechana-29750	47	15	simulation	simulation	NOUN
bibechana-29750	47	16	part	part	NOUN
bibechana-29750	47	17	in	in	ADP
bibechana-29750	47	18	section	section	NOUN
bibechana-29750	47	19	3	3	NUM
bibechana-29750	47	20	,	,	PUNCT
bibechana-29750	47	21	results	result	NOUN
bibechana-29750	47	22	with	with	ADP
bibechana-29750	47	23	discussion	discussion	NOUN
bibechana-29750	47	24	in	in	ADP
bibechana-29750	47	25	section	section	NOUN
bibechana-29750	47	26	4	4	NUM
bibechana-29750	47	27	and	and	CCONJ
bibechana-29750	47	28	finally	finally	ADV
bibechana-29750	47	29	the	the	DET
bibechana-29750	47	30	conclusions	conclusion	NOUN
bibechana-29750	47	31	at	at	ADP
bibechana-29750	47	32	the	the	DET
bibechana-29750	47	33	last	last	ADJ
bibechana-29750	47	34	.	.	PUNCT
bibechana-29750	48	1	jhulan	jhulan	PROPN
bibechana-29750	48	2	powrel	powrel	PROPN
bibechana-29750	48	3	,	,	PUNCT
bibechana-29750	48	4	narayan	narayan	PROPN
bibechana-29750	49	1	p.	p.	NOUN
bibechana-29750	49	2	adhikari/	adhikari/	NUM
bibechana-29750	49	3	bibechana	bibechana	NOUN
bibechana-29750	49	4	18	18	NUM
bibechana-29750	49	5	(	(	PUNCT
bibechana-29750	49	6	1)(2021	1)(2021	NUM
bibechana-29750	49	7	)	)	PUNCT
bibechana-29750	49	8	140	140	NUM
bibechana-29750	49	9	-	-	SYM
bibechana-29750	49	10	148	148	NUM
bibechana-29750	49	11	142	142	NUM
bibechana-29750	49	12	fig	fig	NOUN
bibechana-29750	49	13	.	.	PUNCT
bibechana-29750	50	1	2	2	NUM
bibechana-29750	50	2	:	:	PUNCT
bibechana-29750	50	3	(	(	PUNCT
bibechana-29750	50	4	a	a	X
bibechana-29750	50	5	)	)	PUNCT
bibechana-29750	50	6	normal	normal	ADJ
bibechana-29750	50	7	hemoglobin	hemoglobin	NOUN
bibechana-29750	50	8	with	with	ADP
bibechana-29750	50	9	glutamic	glutamic	ADJ
bibechana-29750	50	10	acid	acid	NOUN
bibechana-29750	50	11	in	in	ADP
bibechana-29750	50	12	6th	6th	ADJ
bibechana-29750	50	13	position	position	NOUN
bibechana-29750	50	14	of	of	ADP
bibechana-29750	50	15	beta	beta	ADJ
bibechana-29750	50	16	chain	chain	NOUN
bibechana-29750	50	17	(	(	PUNCT
bibechana-29750	50	18	left	leave	VERB
bibechana-29750	50	19	)	)	PUNCT
bibechana-29750	50	20	and	and	CCONJ
bibechana-29750	50	21	(	(	PUNCT
bibechana-29750	50	22	b	b	X
bibechana-29750	50	23	)	)	PUNCT
bibechana-29750	50	24	sickle	sickle	NOUN
bibechana-29750	50	25	hemoglobin	hemoglobin	NOUN
bibechana-29750	50	26	protein	protein	NOUN
bibechana-29750	50	27	with	with	ADP
bibechana-29750	50	28	valine	valine	NOUN
bibechana-29750	50	29	in	in	ADP
bibechana-29750	50	30	the	the	DET
bibechana-29750	50	31	6th	6th	ADJ
bibechana-29750	50	32	position	position	NOUN
bibechana-29750	50	33	of	of	ADP
bibechana-29750	50	34	beta	beta	ADJ
bibechana-29750	50	35	chain	chain	NOUN
bibechana-29750	50	36	(	(	PUNCT
bibechana-29750	50	37	right	right	NOUN
bibechana-29750	50	38	)	)	PUNCT
bibechana-29750	50	39	.	.	PUNCT
bibechana-29750	51	1	2	2	X
bibechana-29750	51	2	.	.	X
bibechana-29750	51	3	methods	method	NOUN
bibechana-29750	51	4	and	and	CCONJ
bibechana-29750	51	5	methodology	methodology	NOUN
bibechana-29750	51	6	theory	theory	NOUN
bibechana-29750	51	7	in	in	ADP
bibechana-29750	51	8	molecular	molecular	ADJ
bibechana-29750	51	9	dynamics	dynamic	NOUN
bibechana-29750	51	10	(	(	PUNCT
bibechana-29750	51	11	md	md	PROPN
bibechana-29750	51	12	)	)	PUNCT
bibechana-29750	51	13	,	,	PUNCT
bibechana-29750	51	14	a	a	DET
bibechana-29750	51	15	hemoglobin	hemoglobin	NOUN
bibechana-29750	51	16	protein	protein	NOUN
bibechana-29750	51	17	molecule	molecule	NOUN
bibechana-29750	51	18	is	be	AUX
bibechana-29750	51	19	considered	consider	VERB
bibechana-29750	51	20	inside	inside	ADP
bibechana-29750	51	21	the	the	DET
bibechana-29750	51	22	water	water	NOUN
bibechana-29750	51	23	for	for	ADP
bibechana-29750	51	24	simulation	simulation	NOUN
bibechana-29750	51	25	.	.	PUNCT
bibechana-29750	52	1	protein	protein	NOUN
bibechana-29750	52	2	is	be	AUX
bibechana-29750	52	3	the	the	DET
bibechana-29750	52	4	combination	combination	NOUN
bibechana-29750	52	5	of	of	ADP
bibechana-29750	52	6	a	a	DET
bibechana-29750	52	7	number	number	NOUN
bibechana-29750	52	8	of	of	ADP
bibechana-29750	52	9	atoms	atom	NOUN
bibechana-29750	52	10	which	which	PRON
bibechana-29750	52	11	behaves	behave	VERB
bibechana-29750	52	12	as	as	ADP
bibechana-29750	52	13	pair	pair	NOUN
bibechana-29750	52	14	-	-	PUNCT
bibechana-29750	52	15	wise	wise	ADJ
bibechana-29750	52	16	interaction	interaction	NOUN
bibechana-29750	52	17	in	in	ADP
bibechana-29750	52	18	between	between	ADP
bibechana-29750	52	19	two	two	NUM
bibechana-29750	52	20	atoms	atom	NOUN
bibechana-29750	52	21	in	in	ADP
bibechana-29750	52	22	the	the	DET
bibechana-29750	52	23	molecule	molecule	NOUN
bibechana-29750	52	24	[	[	X
bibechana-29750	52	25	12	12	NUM
bibechana-29750	52	26	]	]	PUNCT
bibechana-29750	52	27	.	.	PUNCT
bibechana-29750	53	1	each	each	DET
bibechana-29750	53	2	pair	pair	NOUN
bibechana-29750	53	3	of	of	ADP
bibechana-29750	53	4	atoms	atom	NOUN
bibechana-29750	53	5	is	be	AUX
bibechana-29750	53	6	interacted	interact	VERB
bibechana-29750	53	7	by	by	ADP
bibechana-29750	53	8	bonded	bond	VERB
bibechana-29750	53	9	and	and	CCONJ
bibechana-29750	53	10	nonbonded	nonbonde	VERB
bibechana-29750	53	11	potentials	potential	NOUN
bibechana-29750	53	12	.	.	PUNCT
bibechana-29750	54	1	the	the	DET
bibechana-29750	54	2	molecular	molecular	ADJ
bibechana-29750	54	3	dynamic	dynamic	ADJ
bibechana-29750	54	4	simulation	simulation	NOUN
bibechana-29750	54	5	calculates	calculate	VERB
bibechana-29750	54	6	the	the	DET
bibechana-29750	54	7	motion	motion	NOUN
bibechana-29750	54	8	of	of	ADP
bibechana-29750	54	9	the	the	DET
bibechana-29750	54	10	atoms	atom	NOUN
bibechana-29750	54	11	in	in	ADP
bibechana-29750	54	12	molecules	molecule	NOUN
bibechana-29750	54	13	using	use	VERB
bibechana-29750	54	14	newtonian	newtonian	ADJ
bibechana-29750	54	15	dynamics	dynamic	NOUN
bibechana-29750	54	16	.	.	PUNCT
bibechana-29750	55	1	in	in	ADP
bibechana-29750	55	2	standard	standard	ADJ
bibechana-29750	55	3	molecular	molecular	ADJ
bibechana-29750	55	4	dynamics	dynamic	NOUN
bibechana-29750	55	5	simulations	simulation	NOUN
bibechana-29750	55	6	the	the	DET
bibechana-29750	55	7	forces	force	NOUN
bibechana-29750	55	8	may	may	AUX
bibechana-29750	55	9	come	come	VERB
bibechana-29750	55	10	from	from	ADP
bibechana-29750	55	11	classical	classical	ADJ
bibechana-29750	55	12	inter	inter	ADJ
bibechana-29750	55	13	atomic	atomic	ADJ
bibechana-29750	55	14	potentials	potential	NOUN
bibechana-29750	55	15	[	[	X
bibechana-29750	55	16	13	13	NUM
bibechana-29750	55	17	]	]	PUNCT
bibechana-29750	55	18	.	.	PUNCT
bibechana-29750	56	1	the	the	DET
bibechana-29750	56	2	non	non	ADJ
bibechana-29750	56	3	-	-	ADJ
bibechana-29750	56	4	bonded	bonded	ADJ
bibechana-29750	56	5	van	van	PROPN
bibechana-29750	56	6	der	der	NOUN
bibechana-29750	56	7	waals	waal	NOUN
bibechana-29750	56	8	and	and	CCONJ
bibechana-29750	56	9	electrostatic	electrostatic	ADJ
bibechana-29750	56	10	are	be	AUX
bibechana-29750	56	11	the	the	DET
bibechana-29750	56	12	interactive	interactive	ADJ
bibechana-29750	56	13	forces	force	NOUN
bibechana-29750	56	14	among	among	ADP
bibechana-29750	56	15	the	the	DET
bibechana-29750	56	16	particles	particle	NOUN
bibechana-29750	56	17	in	in	ADP
bibechana-29750	56	18	the	the	DET
bibechana-29750	56	19	hemoglobin	hemoglobin	NOUN
bibechana-29750	56	20	molecules	molecule	NOUN
bibechana-29750	56	21	.	.	PUNCT
bibechana-29750	57	1	the	the	DET
bibechana-29750	57	2	total	total	ADJ
bibechana-29750	57	3	potential	potential	NOUN
bibechana-29750	57	4	is	be	AUX
bibechana-29750	57	5	obtain	obtain	ADJ
bibechana-29750	57	6	as	as	ADP
bibechana-29750	57	7	,	,	PUNCT
bibechana-29750	57	8	vtotal	vtotal	ADJ
bibechana-29750	57	9	=	=	PUNCT
bibechana-29750	58	1	[	[	X
bibechana-29750	58	2	vbonded	vbonde	VERB
bibechana-29750	58	3	]	]	X
bibechana-29750	58	4	+	+	CCONJ
bibechana-29750	59	1	[	[	X
bibechana-29750	59	2	vnonbonded	vnonbonde	VERB
bibechana-29750	59	3	]	]	PUNCT
bibechana-29750	59	4	(	(	PUNCT
bibechana-29750	59	5	1	1	NUM
bibechana-29750	59	6	)	)	PUNCT
bibechana-29750	59	7	or	or	CCONJ
bibechana-29750	59	8	,	,	PUNCT
bibechana-29750	59	9	vtotal	vtotal	ADJ
bibechana-29750	59	10	=	=	PUNCT
bibechana-29750	60	1	[	[	X
bibechana-29750	60	2	vbond	vbond	X
bibechana-29750	60	3	+	+	CCONJ
bibechana-29750	60	4	vangle	vangle	NOUN
bibechana-29750	60	5	+	+	CCONJ
bibechana-29750	60	6	vimproper	vimproper	NOUN
bibechana-29750	60	7	+	+	CCONJ
bibechana-29750	60	8	vproper	vproper	NOUN
bibechana-29750	60	9	]	]	X
bibechana-29750	60	10	+	+	CCONJ
bibechana-29750	60	11	[	[	X
bibechana-29750	60	12	vlj	vlj	X
bibechana-29750	60	13	+	+	CCONJ
bibechana-29750	60	14	vcoloumb	vcoloumb	ADJ
bibechana-29750	60	15	]	]	PUNCT
bibechana-29750	60	16	(	(	PUNCT
bibechana-29750	60	17	2	2	X
bibechana-29750	60	18	)	)	PUNCT
bibechana-29750	60	19	now	now	ADV
bibechana-29750	60	20	the	the	DET
bibechana-29750	60	21	bond	bond	NOUN
bibechana-29750	60	22	stretching	stretch	VERB
bibechana-29750	60	23	potential	potential	NOUN
bibechana-29750	60	24	is	be	AUX
bibechana-29750	60	25	given	give	VERB
bibechana-29750	60	26	by	by	ADP
bibechana-29750	60	27	,	,	PUNCT
bibechana-29750	60	28	(	(	PUNCT
bibechana-29750	60	29	3	3	X
bibechana-29750	60	30	)	)	PUNCT
bibechana-29750	60	31	where	where	SCONJ
bibechana-29750	60	32	b	b	PROPN
bibechana-29750	60	33	ijk	ijk	PROPN
bibechana-29750	60	34	force	force	NOUN
bibechana-29750	60	35	is	be	AUX
bibechana-29750	60	36	constant	constant	ADJ
bibechana-29750	60	37	,	,	PUNCT
bibechana-29750	60	38	ijr	ijr	PRON
bibechana-29750	60	39	is	be	AUX
bibechana-29750	60	40	separation	separation	NOUN
bibechana-29750	60	41	between	between	ADP
bibechana-29750	60	42	the	the	DET
bibechana-29750	60	43	two	two	NUM
bibechana-29750	60	44	bounded	bounded	ADJ
bibechana-29750	60	45	particles	particle	NOUN
bibechana-29750	60	46	and	and	CCONJ
bibechana-29750	60	47	ijb	ijb	NOUN
bibechana-29750	60	48	is	be	AUX
bibechana-29750	60	49	the	the	DET
bibechana-29750	60	50	equilibrium	equilibrium	NOUN
bibechana-29750	60	51	bond	bond	NOUN
bibechana-29750	60	52	length	length	NOUN
bibechana-29750	60	53	.	.	PUNCT
bibechana-29750	61	1	again	again	ADV
bibechana-29750	61	2	the	the	DET
bibechana-29750	61	3	bond	bond	NOUN
bibechana-29750	61	4	angle	angle	NOUN
bibechana-29750	61	5	potential	potential	NOUN
bibechana-29750	61	6	is	be	AUX
bibechana-29750	61	7	written	write	VERB
bibechana-29750	61	8	as	as	ADP
bibechana-29750	61	9	,	,	PUNCT
bibechana-29750	61	10	)	)	PUNCT
bibechana-29750	61	11	4	4	NUM
bibechana-29750	61	12	(	(	PUNCT
bibechana-29750	61	13	)	)	PUNCT
bibechana-29750	61	14	(	(	PUNCT
bibechana-29750	61	15	2	2	NUM
bibechana-29750	61	16	1	1	NUM
bibechana-29750	61	17	)	)	PUNCT
bibechana-29750	61	18	(	(	PUNCT
bibechana-29750	61	19	20	20	NUM
bibechana-29750	61	20	ijkijkijkijangle	ijkijkijkijangle	PROPN
bibechana-29750	61	21	kv	kv	PROPN
bibechana-29750	61	22			PUNCT
bibechana-29750	61	23			PROPN
bibechana-29750	61	24	−=	−=	PUNCT
bibechana-29750	61	25	where	where	SCONJ
bibechana-29750	61	26	,	,	PUNCT
bibechana-29750	61	27	ijk	ijk	PROPN
bibechana-29750	61	28	0	0	NUM
bibechana-29750	61	29	ijk	ijk	NOUN
bibechana-29750	61	30	and	and	CCONJ
bibechana-29750	61	31			PROPN
bibechana-29750	61	32	ijkk	ijkk	NOUN
bibechana-29750	61	33	are	be	AUX
bibechana-29750	61	34	the	the	DET
bibechana-29750	61	35	bond	bond	NOUN
bibechana-29750	61	36	angle	angle	NOUN
bibechana-29750	61	37	,	,	PUNCT
bibechana-29750	61	38	equilibrium	equilibrium	NOUN
bibechana-29750	61	39	bond	bond	NOUN
bibechana-29750	61	40	angle	angle	NOUN
bibechana-29750	61	41	and	and	CCONJ
bibechana-29750	61	42	the	the	DET
bibechana-29750	61	43	force	force	NOUN
bibechana-29750	61	44	constant	constant	ADJ
bibechana-29750	61	45	respectively	respectively	ADV
bibechana-29750	61	46	.	.	PUNCT
bibechana-29750	62	1	now	now	ADV
bibechana-29750	62	2	the	the	DET
bibechana-29750	62	3	improper	improper	ADJ
bibechana-29750	62	4	dihedral	dihedral	ADJ
bibechana-29750	62	5	potential	potential	ADJ
bibechana-29750	62	6	energy	energy	NOUN
bibechana-29750	62	7	is	be	AUX
bibechana-29750	62	8	,	,	PUNCT
bibechana-29750	62	9	)	)	PUNCT
bibechana-29750	62	10	5	5	NUM
bibechana-29750	62	11	(	(	PUNCT
bibechana-29750	62	12	)	)	PUNCT
bibechana-29750	62	13	(	(	PUNCT
bibechana-29750	62	14	2	2	NUM
bibechana-29750	62	15	1	1	NUM
bibechana-29750	62	16	)	)	PUNCT
bibechana-29750	62	17	(	(	PUNCT
bibechana-29750	62	18	2	2	NUM
bibechana-29750	62	19	0	0	NUM
bibechana-29750	62	20			NOUN
bibechana-29750	62	21	−=	−=	VERB
bibechana-29750	62	22	ijklijklimproper	ijklijklimproper	ADJ
bibechana-29750	62	23	kv	kv	PROPN
bibechana-29750	62	24	where	where	SCONJ
bibechana-29750	62	25	0	0	NUM
bibechana-29750	62	26	is	be	AUX
bibechana-29750	62	27	the	the	DET
bibechana-29750	62	28	equilibrium	equilibrium	NOUN
bibechana-29750	62	29	improper	improper	ADJ
bibechana-29750	62	30	angle	angle	NOUN
bibechana-29750	62	31	and	and	CCONJ
bibechana-29750	62	32	k	k	NOUN
bibechana-29750	62	33	is	be	AUX
bibechana-29750	62	34	the	the	DET
bibechana-29750	62	35	constant	constant	ADJ
bibechana-29750	62	36	.	.	PUNCT
bibechana-29750	63	1	similarly	similarly	ADV
bibechana-29750	63	2	the	the	DET
bibechana-29750	63	3	dihedral	dihedral	ADJ
bibechana-29750	63	4	potential	potential	NOUN
bibechana-29750	63	5	is	be	AUX
bibechana-29750	63	6	,	,	PUNCT
bibechana-29750	63	7	)	)	PUNCT
bibechana-29750	63	8	6())cos(1	6())cos(1	NUM
bibechana-29750	63	9	(	(	PUNCT
bibechana-29750	63	10	2	2	NUM
bibechana-29750	63	11	1	1	NUM
bibechana-29750	63	12	)	)	PUNCT
bibechana-29750	63	13	(	(	PUNCT
bibechana-29750	63	14	sijklijklproper	sijklijklproper	ADJ
bibechana-29750	63	15	nkv	nkv	NOUN
bibechana-29750	63	16			VERB
bibechana-29750	63	17			NOUN
bibechana-29750	63	18	−+=	−+=	NOUN
bibechana-29750	63	19	where	where	SCONJ
bibechana-29750	63	20	ijkl	ijkl	PROPN
bibechana-29750	63	21	is	be	AUX
bibechana-29750	63	22	the	the	DET
bibechana-29750	63	23	proper	proper	ADJ
bibechana-29750	63	24	dihedral	dihedral	ADJ
bibechana-29750	63	25	angle	angle	NOUN
bibechana-29750	63	26	,	,	PUNCT
bibechana-29750	63	27	s	s	PROPN
bibechana-29750	63	28	is	be	AUX
bibechana-29750	63	29	an	an	DET
bibechana-29750	63	30	angle	angle	NOUN
bibechana-29750	63	31	at	at	ADP
bibechana-29750	63	32	which	which	PRON
bibechana-29750	63	33	the	the	DET
bibechana-29750	63	34	potential	potential	NOUN
bibechana-29750	63	35	is	be	AUX
bibechana-29750	63	36	maximum	maximum	ADJ
bibechana-29750	63	37	,	,	PUNCT
bibechana-29750	63	38	n	n	PRON
bibechana-29750	63	39	is	be	AUX
bibechana-29750	63	40	the	the	DET
bibechana-29750	63	41	multiplicity	multiplicity	NOUN
bibechana-29750	63	42	and	and	CCONJ
bibechana-29750	63	43	k	k	NUM
bibechana-29750	63	44	is	be	AUX
bibechana-29750	63	45	the	the	DET
bibechana-29750	63	46	barrier	barrier	NOUN
bibechana-29750	63	47	height	height	NOUN
bibechana-29750	63	48	.	.	PUNCT
bibechana-29750	64	1	(	(	PUNCT
bibechana-29750	64	2	)	)	PUNCT
bibechana-29750	64	3	.	.	PUNCT
bibechana-29750	65	1	2	2	NUM
bibechana-29750	65	2	1	1	NUM
bibechana-29750	65	3	)	)	PUNCT
bibechana-29750	65	4	(	(	PUNCT
bibechana-29750	65	5	2	2	NUM
bibechana-29750	65	6	ijijij	ijijij	NOUN
bibechana-29750	65	7	b	b	PROPN
bibechana-29750	65	8	ijbond	ijbond	PROPN
bibechana-29750	65	9	brkrv	brkrv	PROPN
bibechana-29750	65	10	−=	−=	PROPN
bibechana-29750	65	11	jhulan	jhulan	PROPN
bibechana-29750	65	12	powrel	powrel	NOUN
bibechana-29750	65	13	,	,	PUNCT
bibechana-29750	65	14	narayan	narayan	PROPN
bibechana-29750	66	1	p.	p.	NOUN
bibechana-29750	66	2	adhikari/	adhikari/	NUM
bibechana-29750	66	3	bibechana	bibechana	NOUN
bibechana-29750	66	4	18	18	NUM
bibechana-29750	66	5	(	(	PUNCT
bibechana-29750	66	6	1)(2021	1)(2021	NUM
bibechana-29750	66	7	)	)	PUNCT
bibechana-29750	66	8	140	140	NUM
bibechana-29750	66	9	-	-	SYM
bibechana-29750	66	10	148	148	NUM
bibechana-29750	66	11	143	143	NUM
bibechana-29750	66	12	although	although	SCONJ
bibechana-29750	66	13	lennard	lennard	PROPN
bibechana-29750	66	14	-	-	PUNCT
bibechana-29750	66	15	jones	jones	PROPN
bibechana-29750	66	16	potential(l	potential(l	PROPN
bibechana-29750	66	17	-	-	PUNCT
bibechana-29750	66	18	j	j	NOUN
bibechana-29750	66	19	)	)	PUNCT
bibechana-29750	66	20	is	be	AUX
bibechana-29750	66	21	not	not	PART
bibechana-29750	66	22	suitable	suitable	ADJ
bibechana-29750	66	23	for	for	ADP
bibechana-29750	66	24	system	system	NOUN
bibechana-29750	66	25	where	where	SCONJ
bibechana-29750	66	26	strong	strong	ADJ
bibechana-29750	66	27	localized	localized	ADJ
bibechana-29750	66	28	bonds	bond	NOUN
bibechana-29750	66	29	may	may	AUX
bibechana-29750	66	30	form	form	VERB
bibechana-29750	66	31	(	(	PUNCT
bibechana-29750	66	32	as	as	ADP
bibechana-29750	66	33	in	in	ADP
bibechana-29750	66	34	covalent	covalent	ADJ
bibechana-29750	66	35	system	system	NOUN
bibechana-29750	66	36	)	)	PUNCT
bibechana-29750	66	37	or	or	CCONJ
bibechana-29750	66	38	there	there	PRON
bibechana-29750	66	39	is	be	VERB
bibechana-29750	66	40	a	a	DET
bibechana-29750	66	41	delocalized	delocalize	VERB
bibechana-29750	66	42	electron	electron	NOUN
bibechana-29750	66	43	sea	sea	NOUN
bibechana-29750	66	44	where	where	SCONJ
bibechana-29750	66	45	the	the	DET
bibechana-29750	66	46	ions	ion	NOUN
bibechana-29750	66	47	remain	remain	VERB
bibechana-29750	66	48	(	(	PUNCT
bibechana-29750	66	49	as	as	ADP
bibechana-29750	66	50	in	in	ADP
bibechana-29750	66	51	metals	metal	NOUN
bibechana-29750	66	52	)	)	PUNCT
bibechana-29750	66	53	,	,	PUNCT
bibechana-29750	66	54	the	the	DET
bibechana-29750	66	55	l	l	PROPN
bibechana-29750	66	56	-	-	PROPN
bibechana-29750	66	57	j	j	PROPN
bibechana-29750	66	58	potential	potential	NOUN
bibechana-29750	66	59	helped	help	VERB
bibechana-29750	66	60	us	we	PRON
bibechana-29750	66	61	to	to	PART
bibechana-29750	66	62	understand	understand	VERB
bibechana-29750	66	63	basic	basic	ADJ
bibechana-29750	66	64	points	point	NOUN
bibechana-29750	66	65	in	in	ADP
bibechana-29750	66	66	many	many	ADJ
bibechana-29750	66	67	areas	area	NOUN
bibechana-29750	66	68	of	of	ADP
bibechana-29750	66	69	condensed	condense	VERB
bibechana-29750	66	70	matter	matter	NOUN
bibechana-29750	66	71	physics	physics	NOUN
bibechana-29750	66	72	.	.	PUNCT
bibechana-29750	67	1	the	the	DET
bibechana-29750	67	2	l	l	PROPN
bibechana-29750	67	3	-	-	PROPN
bibechana-29750	67	4	j	j	PROPN
bibechana-29750	67	5	potential	potential	NOUN
bibechana-29750	67	6	for	for	ADP
bibechana-29750	67	7	interaction	interaction	NOUN
bibechana-29750	67	8	between	between	ADP
bibechana-29750	67	9	a	a	DET
bibechana-29750	67	10	pair	pair	NOUN
bibechana-29750	67	11	of	of	ADP
bibechana-29750	67	12	atom	atom	NOUN
bibechana-29750	67	13	is	be	AUX
bibechana-29750	67	14	given	give	VERB
bibechana-29750	67	15	by	by	ADP
bibechana-29750	67	16	[	[	X
bibechana-29750	67	17	14	14	NUM
bibechana-29750	67	18	]	]	PUNCT
bibechana-29750	67	19	,	,	PUNCT
bibechana-29750	67	20	)	)	PUNCT
bibechana-29750	67	21	7(4	7(4	NUM
bibechana-29750	67	22	612	612	NUM
bibechana-29750	67	23			NOUN
bibechana-29750	67	24			PROPN
bibechana-29750	67	25			PROPN
bibechana-29750	67	26			X
bibechana-29750	67	27			NOUN
bibechana-29750	67	28			X
bibechana-29750	67	29			VERB
bibechana-29750	67	30			PROPN
bibechana-29750	67	31			PROPN
bibechana-29750	67	32			NOUN
bibechana-29750	67	33			PRON
bibechana-29750	67	34			PROPN
bibechana-29750	67	35			PROPN
bibechana-29750	67	36			NOUN
bibechana-29750	67	37	−	−	ADP
bibechana-29750	67	38			NOUN
bibechana-29750	67	39			PRON
bibechana-29750	67	40			PROPN
bibechana-29750	67	41			PROPN
bibechana-29750	67	42			NOUN
bibechana-29750	67	43	=	=	PUNCT
bibechana-29750	67	44	rr	rr	NOUN
bibechana-29750	67	45	vlj	vlj	PROPN
bibechana-29750	67	46			X
bibechana-29750	67	47			PROPN
bibechana-29750	67	48	where	where	SCONJ
bibechana-29750	67	49	ε	ε	PROPN
bibechana-29750	67	50	is	be	AUX
bibechana-29750	67	51	the	the	DET
bibechana-29750	67	52	depth	depth	NOUN
bibechana-29750	67	53	of	of	ADP
bibechana-29750	67	54	the	the	DET
bibechana-29750	67	55	attractive	attractive	ADJ
bibechana-29750	67	56	well	well	NOUN
bibechana-29750	67	57	,	,	PUNCT
bibechana-29750	67	58	σ	σ	PROPN
bibechana-29750	67	59	refers	refer	VERB
bibechana-29750	67	60	to	to	ADP
bibechana-29750	67	61	the	the	DET
bibechana-29750	67	62	inter	inter	ADJ
bibechana-29750	67	63	-	-	ADJ
bibechana-29750	67	64	particle	particle	ADJ
bibechana-29750	67	65	distance	distance	NOUN
bibechana-29750	67	66	and	and	CCONJ
bibechana-29750	67	67	defines	define	VERB
bibechana-29750	67	68	the	the	DET
bibechana-29750	67	69	strength	strength	NOUN
bibechana-29750	67	70	of	of	ADP
bibechana-29750	67	71	the	the	DET
bibechana-29750	67	72	interaction	interaction	NOUN
bibechana-29750	67	73	where	where	SCONJ
bibechana-29750	67	74	the	the	DET
bibechana-29750	67	75	potential	potential	ADJ
bibechana-29750	67	76	changes	change	NOUN
bibechana-29750	67	77	sign	sign	VERB
bibechana-29750	67	78	and	and	CCONJ
bibechana-29750	67	79	r	r	NOUN
bibechana-29750	67	80	defines	define	VERB
bibechana-29750	67	81	the	the	DET
bibechana-29750	67	82	length	length	NOUN
bibechana-29750	67	83	scale	scale	NOUN
bibechana-29750	67	84	.	.	PUNCT
bibechana-29750	68	1	the	the	DET
bibechana-29750	68	2	coulomb	coulomb	NOUN
bibechana-29750	68	3	electrostatic	electrostatic	ADJ
bibechana-29750	68	4	interaction	interaction	NOUN
bibechana-29750	68	5	between	between	ADP
bibechana-29750	68	6	two	two	NUM
bibechana-29750	68	7	point	point	NOUN
bibechana-29750	68	8	charges	charge	NOUN
bibechana-29750	68	9	qi	qi	PROPN
bibechana-29750	68	10	and	and	CCONJ
bibechana-29750	68	11	qj	qj	PROPN
bibechana-29750	68	12	is	be	AUX
bibechana-29750	68	13	defined	define	VERB
bibechana-29750	68	14	by	by	ADP
bibechana-29750	68	15	coulomb	coulomb	NOUN
bibechana-29750	68	16	potential	potential	NOUN
bibechana-29750	68	17	as	as	ADP
bibechana-29750	68	18	,	,	PUNCT
bibechana-29750	68	19	)	)	PUNCT
bibechana-29750	68	20	8	8	NUM
bibechana-29750	68	21	(	(	PUNCT
bibechana-29750	68	22	4	4	NUM
bibechana-29750	68	23	2r	2r	NUM
bibechana-29750	68	24	qq	qq	NOUN
bibechana-29750	68	25	v	v	INTJ
bibechana-29750	68	26	m	m	NOUN
bibechana-29750	68	27	ji	ji	PROPN
bibechana-29750	68	28	coloumb	coloumb	PROPN
bibechana-29750	68	29			PROPN
bibechana-29750	69	1	=	=	SYM
bibechana-29750	69	2	root	root	NOUN
bibechana-29750	69	3	mean	mean	VERB
bibechana-29750	69	4	square	square	ADJ
bibechana-29750	69	5	deviation	deviation	NOUN
bibechana-29750	69	6	(	(	PUNCT
bibechana-29750	69	7	rmsd	rmsd	NOUN
bibechana-29750	69	8	):	):	PUNCT
bibechana-29750	69	9	rmsd	rmsd	NOUN
bibechana-29750	69	10	is	be	AUX
bibechana-29750	69	11	the	the	DET
bibechana-29750	69	12	level	level	NOUN
bibechana-29750	69	13	of	of	ADP
bibechana-29750	69	14	equilibration	equilibration	NOUN
bibechana-29750	69	15	and	and	CCONJ
bibechana-29750	69	16	gives	give	VERB
bibechana-29750	69	17	the	the	DET
bibechana-29750	69	18	deviation	deviation	NOUN
bibechana-29750	69	19	of	of	ADP
bibechana-29750	69	20	the	the	DET
bibechana-29750	69	21	molecules	molecule	NOUN
bibechana-29750	69	22	from	from	ADP
bibechana-29750	69	23	the	the	DET
bibechana-29750	69	24	defined	define	VERB
bibechana-29750	69	25	position	position	NOUN
bibechana-29750	69	26	in	in	ADP
bibechana-29750	69	27	space	space	NOUN
bibechana-29750	69	28	.	.	PUNCT
bibechana-29750	70	1	it	it	PRON
bibechana-29750	70	2	also	also	ADV
bibechana-29750	70	3	gives	give	VERB
bibechana-29750	70	4	the	the	DET
bibechana-29750	70	5	idea	idea	NOUN
bibechana-29750	70	6	of	of	ADP
bibechana-29750	70	7	occurrence	occurrence	NOUN
bibechana-29750	70	8	of	of	ADP
bibechana-29750	70	9	the	the	DET
bibechana-29750	70	10	reaction	reaction	NOUN
bibechana-29750	70	11	in	in	ADP
bibechana-29750	70	12	chemical	chemical	ADJ
bibechana-29750	70	13	bonding	bonding	NOUN
bibechana-29750	70	14	.	.	PUNCT
bibechana-29750	71	1	the	the	PRON
bibechana-29750	71	2	larger	large	ADJ
bibechana-29750	71	3	the	the	DET
bibechana-29750	71	4	deviation	deviation	NOUN
bibechana-29750	71	5	from	from	ADP
bibechana-29750	71	6	mean	mean	ADJ
bibechana-29750	71	7	position	position	NOUN
bibechana-29750	71	8	less	less	ADJ
bibechana-29750	71	9	will	will	AUX
bibechana-29750	71	10	be	be	AUX
bibechana-29750	71	11	the	the	DET
bibechana-29750	71	12	stability	stability	NOUN
bibechana-29750	71	13	of	of	ADP
bibechana-29750	71	14	the	the	DET
bibechana-29750	71	15	system	system	NOUN
bibechana-29750	71	16	.	.	PUNCT
bibechana-29750	72	1	rmsd	rmsd	NOUN
bibechana-29750	72	2	values	value	NOUN
bibechana-29750	72	3	are	be	AUX
bibechana-29750	72	4	calculated	calculate	VERB
bibechana-29750	72	5	for	for	ADP
bibechana-29750	72	6	all	all	DET
bibechana-29750	72	7	atoms	atom	NOUN
bibechana-29750	72	8	of	of	ADP
bibechana-29750	72	9	the	the	DET
bibechana-29750	72	10	hemoglobin	hemoglobin	NOUN
bibechana-29750	72	11	protein	protein	NOUN
bibechana-29750	72	12	backbone	backbone	NOUN
bibechana-29750	72	13	for	for	ADP
bibechana-29750	72	14	the	the	DET
bibechana-29750	72	15	entire	entire	ADJ
bibechana-29750	72	16	protein	protein	NOUN
bibechana-29750	72	17	and	and	CCONJ
bibechana-29750	72	18	for	for	ADP
bibechana-29750	72	19	the	the	DET
bibechana-29750	72	20	protein	protein	NOUN
bibechana-29750	72	21	excluding	exclude	VERB
bibechana-29750	72	22	the	the	DET
bibechana-29750	72	23	last	last	ADJ
bibechana-29750	72	24	five	five	NUM
bibechana-29750	72	25	residues[15	residues[15	NOUN
bibechana-29750	72	26	]	]	PUNCT
bibechana-29750	72	27	,	,	PUNCT
bibechana-29750	72	28	which	which	PRON
bibechana-29750	72	29	is	be	AUX
bibechana-29750	72	30	the	the	DET
bibechana-29750	72	31	numerical	numerical	ADJ
bibechana-29750	72	32	measure	measure	NOUN
bibechana-29750	72	33	of	of	ADP
bibechana-29750	72	34	the	the	DET
bibechana-29750	72	35	structural	structural	ADJ
bibechana-29750	72	36	difference	difference	NOUN
bibechana-29750	72	37	of	of	ADP
bibechana-29750	72	38	two	two	NUM
bibechana-29750	72	39	states	state	NOUN
bibechana-29750	72	40	given	give	VERB
bibechana-29750	72	41	by	by	ADP
bibechana-29750	72	42	,	,	PUNCT
bibechana-29750	72	43	(	(	PUNCT
bibechana-29750	72	44	)	)	PUNCT
bibechana-29750	72	45	(	(	PUNCT
bibechana-29750	72	46	)	)	PUNCT
bibechana-29750	72	47	(	(	PUNCT
bibechana-29750	72	48	)	)	PUNCT
bibechana-29750	72	49	)	)	PUNCT
bibechana-29750	72	50	9	9	NUM
bibechana-29750	72	51	(	(	PUNCT
bibechana-29750	72	52	2	2	NUM
bibechana-29750	72	53	1	1	NUM
bibechana-29750	72	54	t	t	NOUN
bibechana-29750	72	55	jj	jj	PROPN
bibechana-29750	72	56	n	n	PROPN
bibechana-29750	72	57	j	j	PROPN
bibechana-29750	72	58	n	n	PRON
bibechana-29750	72	59	trtr	trtr	NOUN
bibechana-29750	72	60	trmsd	trmsd	PROPN
bibechana-29750	72	61			PROPN
bibechana-29750	72	62			VERB
bibechana-29750	72	63			PRON
bibechana-29750	72	64			PROPN
bibechana-29750	72	65			PROPN
bibechana-29750	72	66			NOUN
bibechana-29750	72	67	−	−	NOUN
bibechana-29750	73	1	=	=	PUNCT
bibechana-29750	74	1	=	=	NOUN
bibechana-29750	75	1			X
bibechana-29750	75	2			NOUN
bibechana-29750	75	3	with	with	ADP
bibechana-29750	75	4	(	(	PUNCT
bibechana-29750	75	5	)	)	PUNCT
bibechana-29750	75	6	(	(	PUNCT
bibechana-29750	75	7	)	)	PUNCT
bibechana-29750	75	8	)	)	PUNCT
bibechana-29750	75	9	10	10	NUM
bibechana-29750	75	10	(	(	PUNCT
bibechana-29750	75	11	1	1	NUM
bibechana-29750	75	12	1	1	NUM
bibechana-29750	75	13	j	j	PROPN
bibechana-29750	75	14	n	n	NUM
bibechana-29750	75	15	j	j	PROPN
bibechana-29750	75	16	t	t	PROPN
bibechana-29750	75	17	j	j	PROPN
bibechana-29750	76	1	tr	tr	PROPN
bibechana-29750	76	2	n	n	PROPN
bibechana-29750	76	3	tr	tr	NOUN
bibechana-29750	76	4	t	t	PROPN
bibechana-29750	76	5			NUM
bibechana-29750	76	6	=	=	PUNCT
bibechana-29750	76	7	=	=	X
bibechana-29750	76	8	where	where	SCONJ
bibechana-29750	76	9	nα	nα	NOUN
bibechana-29750	76	10	is	be	AUX
bibechana-29750	76	11	the	the	DET
bibechana-29750	76	12	number	number	NOUN
bibechana-29750	76	13	of	of	ADP
bibechana-29750	76	14	atoms	atom	NOUN
bibechana-29750	76	15	whose	whose	DET
bibechana-29750	76	16	positions	position	NOUN
bibechana-29750	76	17	are	be	AUX
bibechana-29750	76	18	compared	compare	VERB
bibechana-29750	76	19	,	,	PUNCT
bibechana-29750	76	20	nt	not	PART
bibechana-29750	76	21	is	be	AUX
bibechana-29750	76	22	the	the	DET
bibechana-29750	76	23	number	number	NOUN
bibechana-29750	76	24	of	of	ADP
bibechana-29750	76	25	time	time	NOUN
bibechana-29750	76	26	steps	step	NOUN
bibechana-29750	76	27	over	over	ADP
bibechana-29750	76	28	which	which	PRON
bibechana-29750	76	29	atomic	atomic	ADJ
bibechana-29750	76	30	positions	position	NOUN
bibechana-29750	76	31	are	be	AUX
bibechana-29750	76	32	compared	compare	VERB
bibechana-29750	76	33	,	,	PUNCT
bibechana-29750	76	34	→−rα(tj	→−rα(tj	NUM
bibechana-29750	76	35	)	)	PUNCT
bibechana-29750	76	36	is	be	AUX
bibechana-29750	76	37	the	the	DET
bibechana-29750	76	38	position	position	NOUN
bibechana-29750	76	39	of	of	ADP
bibechana-29750	76	40	atom	atom	NOUN
bibechana-29750	76	41	α	α	NOUN
bibechana-29750	76	42	at	at	ADP
bibechana-29750	76	43	time	time	NOUN
bibechana-29750	76	44	tj	tj	PROPN
bibechana-29750	76	45	and	and	CCONJ
bibechana-29750	76	46	(	(	PUNCT
bibechana-29750	76	47	)	)	PUNCT
bibechana-29750	76	48	jtr	jtr	PROPN
bibechana-29750	76	49	is	be	AUX
bibechana-29750	76	50	the	the	DET
bibechana-29750	76	51	average	average	ADJ
bibechana-29750	76	52	value	value	NOUN
bibechana-29750	76	53	of	of	ADP
bibechana-29750	76	54	the	the	DET
bibechana-29750	76	55	position	position	NOUN
bibechana-29750	76	56	of	of	ADP
bibechana-29750	76	57	atom	atom	NOUN
bibechana-29750	76	58	to	to	PART
bibechana-29750	76	59	which	which	PRON
bibechana-29750	76	60	the	the	DET
bibechana-29750	76	61	positions	position	NOUN
bibechana-29750	76	62	→−r	→−r	PUNCT
bibechana-29750	76	63	α(tj	α(tj	PROPN
bibechana-29750	76	64	)	)	PUNCT
bibechana-29750	76	65	are	be	AUX
bibechana-29750	76	66	being	be	AUX
bibechana-29750	76	67	compared[15	compared[15	PROPN
bibechana-29750	76	68	]	]	X
bibechana-29750	76	69	.	.	PUNCT
bibechana-29750	77	1	specific	specific	ADJ
bibechana-29750	77	2	heat	heat	NOUN
bibechana-29750	77	3	capacity	capacity	NOUN
bibechana-29750	77	4	:	:	PUNCT
bibechana-29750	77	5	the	the	DET
bibechana-29750	77	6	specific	specific	ADJ
bibechana-29750	77	7	heat	heat	NOUN
bibechana-29750	77	8	capacity	capacity	NOUN
bibechana-29750	77	9	is	be	AUX
bibechana-29750	77	10	the	the	DET
bibechana-29750	77	11	amount	amount	NOUN
bibechana-29750	77	12	of	of	ADP
bibechana-29750	77	13	heat	heat	NOUN
bibechana-29750	77	14	required	require	VERB
bibechana-29750	77	15	for	for	ADP
bibechana-29750	77	16	raising	raise	VERB
bibechana-29750	77	17	the	the	DET
bibechana-29750	77	18	temperature	temperature	NOUN
bibechana-29750	77	19	of	of	ADP
bibechana-29750	77	20	an	an	DET
bibechana-29750	77	21	object	object	NOUN
bibechana-29750	77	22	per	per	ADP
bibechana-29750	77	23	degree	degree	NOUN
bibechana-29750	77	24	of	of	ADP
bibechana-29750	77	25	temperature	temperature	NOUN
bibechana-29750	77	26	increase	increase	NOUN
bibechana-29750	77	27	per	per	ADP
bibechana-29750	77	28	unit	unit	NOUN
bibechana-29750	77	29	mass	mass	PROPN
bibechana-29750	77	30	.	.	PUNCT
bibechana-29750	78	1	thus	thus	ADV
bibechana-29750	78	2	in	in	ADP
bibechana-29750	78	3	canonical	canonical	ADJ
bibechana-29750	78	4	ensemble	ensemble	ADJ
bibechana-29750	78	5	the	the	DET
bibechana-29750	78	6	specific	specific	ADJ
bibechana-29750	78	7	heat	heat	NOUN
bibechana-29750	78	8	capacity	capacity	NOUN
bibechana-29750	78	9	is	be	AUX
bibechana-29750	78	10	[	[	X
bibechana-29750	78	11	16	16	NUM
bibechana-29750	78	12	]	]	PUNCT
bibechana-29750	78	13	,	,	PUNCT
bibechana-29750	78	14	)	)	PUNCT
bibechana-29750	78	15	11	11	NUM
bibechana-29750	78	16	(	(	PUNCT
bibechana-29750	78	17	tk	tk	PROPN
bibechana-29750	78	18	2	2	NUM
bibechana-29750	78	19	b	b	SYM
bibechana-29750	78	20	22	22	NUM
bibechana-29750	79	1	bb	bb	NUM
bibechana-29750	79	2	v	v	NOUN
bibechana-29750	79	3	ee	ee	ADP
bibechana-29750	79	4	c	c	NOUN
bibechana-29750	79	5	−	−	PROPN
bibechana-29750	80	1	=	=	PUNCT
bibechana-29750	80	2	where	where	SCONJ
bibechana-29750	80	3	2	2	NUM
bibechana-29750	80	4	be	be	NOUN
bibechana-29750	80	5	is	be	AUX
bibechana-29750	80	6	square	square	ADJ
bibechana-29750	80	7	of	of	ADP
bibechana-29750	80	8	the	the	DET
bibechana-29750	80	9	average	average	NOUN
bibechana-29750	80	10	of	of	ADP
bibechana-29750	80	11	the	the	DET
bibechana-29750	80	12	total	total	ADJ
bibechana-29750	80	13	energies	energy	NOUN
bibechana-29750	80	14	and	and	CCONJ
bibechana-29750	80	15	2	2	NUM
bibechana-29750	80	16	be	be	NOUN
bibechana-29750	80	17	is	be	AUX
bibechana-29750	80	18	the	the	DET
bibechana-29750	80	19	average	average	NOUN
bibechana-29750	80	20	of	of	ADP
bibechana-29750	80	21	the	the	DET
bibechana-29750	80	22	square	square	NOUN
bibechana-29750	80	23	of	of	ADP
bibechana-29750	80	24	the	the	DET
bibechana-29750	80	25	total	total	ADJ
bibechana-29750	80	26	energy	energy	NOUN
bibechana-29750	80	27	and	and	CCONJ
bibechana-29750	80	28	bk	bk	PUNCT
bibechana-29750	80	29	the	the	DET
bibechana-29750	80	30	boltzmann	boltzmann	PROPN
bibechana-29750	80	31	constant	constant	PROPN
bibechana-29750	80	32	.	.	PUNCT
bibechana-29750	81	1	3	3	X
bibechana-29750	81	2	.	.	X
bibechana-29750	81	3	computational	computational	ADJ
bibechana-29750	81	4	details	detail	NOUN
bibechana-29750	81	5	the	the	DET
bibechana-29750	81	6	proposed	propose	VERB
bibechana-29750	81	7	research	research	NOUN
bibechana-29750	81	8	is	be	AUX
bibechana-29750	81	9	designed	design	VERB
bibechana-29750	81	10	for	for	ADP
bibechana-29750	81	11	working	work	VERB
bibechana-29750	81	12	in	in	ADP
bibechana-29750	81	13	theoretical	theoretical	ADJ
bibechana-29750	81	14	computational	computational	ADJ
bibechana-29750	81	15	method	method	NOUN
bibechana-29750	81	16	using	use	VERB
bibechana-29750	81	17	molecular	molecular	ADJ
bibechana-29750	81	18	dynamics	dynamic	NOUN
bibechana-29750	81	19	.	.	PUNCT
bibechana-29750	82	1	hemoglobin	hemoglobin	NOUN
bibechana-29750	82	2	protein	protein	NOUN
bibechana-29750	82	3	of	of	ADP
bibechana-29750	82	4	sickle	sickle	NOUN
bibechana-29750	82	5	and	and	CCONJ
bibechana-29750	82	6	normal	normal	ADJ
bibechana-29750	82	7	cell	cell	NOUN
bibechana-29750	82	8	are	be	AUX
bibechana-29750	82	9	obtained	obtain	VERB
bibechana-29750	82	10	from	from	ADP
bibechana-29750	82	11	the	the	DET
bibechana-29750	82	12	rcsb	rcsb	NOUN
bibechana-29750	82	13	(	(	PUNCT
bibechana-29750	82	14	research	research	NOUN
bibechana-29750	82	15	collaboratory	collaboratory	NOUN
bibechana-29750	82	16	for	for	ADP
bibechana-29750	82	17	structural	structural	ADJ
bibechana-29750	82	18	bioinformatics).org	bioinformatics).org	PROPN
bibechana-29750	82	19	in	in	ADP
bibechana-29750	82	20	pdb	pdb	PROPN
bibechana-29750	82	21	(	(	PUNCT
bibechana-29750	82	22	protein	protein	NOUN
bibechana-29750	82	23	data	data	PROPN
bibechana-29750	82	24	bank	bank	NOUN
bibechana-29750	82	25	)	)	PUNCT
bibechana-29750	82	26	form	form	NOUN
bibechana-29750	82	27	and	and	CCONJ
bibechana-29750	82	28	then	then	ADV
bibechana-29750	82	29	simulation	simulation	NOUN
bibechana-29750	82	30	is	be	AUX
bibechana-29750	82	31	completed	complete	VERB
bibechana-29750	82	32	using	use	VERB
bibechana-29750	82	33	namd	namd	NOUN
bibechana-29750	82	34	(	(	PUNCT
bibechana-29750	82	35	nano	nano	NOUN
bibechana-29750	82	36	scale	scale	NOUN
bibechana-29750	82	37	molecular	molecular	ADJ
bibechana-29750	82	38	dynamics	dynamic	NOUN
bibechana-29750	82	39	)	)	PUNCT
bibechana-29750	82	40	and	and	CCONJ
bibechana-29750	82	41	vmd	vmd	PROPN
bibechana-29750	82	42	(	(	PUNCT
bibechana-29750	82	43	visual	visual	ADJ
bibechana-29750	82	44	molecular	molecular	ADJ
bibechana-29750	82	45	dynamics	dynamic	NOUN
bibechana-29750	82	46	)	)	PUNCT
bibechana-29750	82	47	software	software	NOUN
bibechana-29750	82	48	by	by	ADP
bibechana-29750	82	49	following	follow	VERB
bibechana-29750	82	50	the	the	DET
bibechana-29750	82	51	steps	step	NOUN
bibechana-29750	82	52	of	of	ADP
bibechana-29750	82	53	structure	structure	NOUN
bibechana-29750	82	54	making	making	NOUN
bibechana-29750	82	55	,	,	PUNCT
bibechana-29750	82	56	energy	energy	NOUN
bibechana-29750	82	57	minimization	minimization	NOUN
bibechana-29750	82	58	and	and	CCONJ
bibechana-29750	82	59	making	making	NOUN
bibechana-29750	82	60	of	of	ADP
bibechana-29750	82	61	equilibration	equilibration	NOUN
bibechana-29750	82	62	in	in	ADP
bibechana-29750	82	63	the	the	DET
bibechana-29750	82	64	system	system	NOUN
bibechana-29750	82	65	.	.	PUNCT
bibechana-29750	83	1	after	after	ADP
bibechana-29750	83	2	performing	perform	VERB
bibechana-29750	83	3	various	various	ADJ
bibechana-29750	83	4	simulation	simulation	NOUN
bibechana-29750	83	5	steps	step	VERB
bibechana-29750	83	6	the	the	DET
bibechana-29750	83	7	output	output	NOUN
bibechana-29750	83	8	data	datum	NOUN
bibechana-29750	83	9	are	be	AUX
bibechana-29750	83	10	used	use	VERB
bibechana-29750	83	11	for	for	ADP
bibechana-29750	83	12	the	the	DET
bibechana-29750	83	13	calculations	calculation	NOUN
bibechana-29750	83	14	of	of	ADP
bibechana-29750	83	15	rmsd	rmsd	NOUN
bibechana-29750	83	16	and	and	CCONJ
bibechana-29750	83	17	specific	specific	ADJ
bibechana-29750	83	18	heat	heat	NOUN
bibechana-29750	83	19	capacity	capacity	NOUN
bibechana-29750	83	20	of	of	ADP
bibechana-29750	83	21	both	both	PRON
bibechana-29750	83	22	of	of	ADP
bibechana-29750	83	23	the	the	DET
bibechana-29750	83	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	83	25	protein	protein	NOUN
bibechana-29750	83	26	.	.	PUNCT
bibechana-29750	84	1	for	for	ADP
bibechana-29750	84	2	this	this	DET
bibechana-29750	84	3	simulation	simulation	NOUN
bibechana-29750	84	4	six	six	NUM
bibechana-29750	84	5	systems	system	NOUN
bibechana-29750	84	6	are	be	AUX
bibechana-29750	84	7	designed	design	VERB
bibechana-29750	84	8	with	with	ADP
bibechana-29750	84	9	four	four	NUM
bibechana-29750	84	10	molecules	molecule	NOUN
bibechana-29750	84	11	which	which	PRON
bibechana-29750	84	12	are	be	AUX
bibechana-29750	84	13	then	then	ADV
bibechana-29750	84	14	solvated	solvate	VERB
bibechana-29750	84	15	with	with	ADP
bibechana-29750	84	16	water	water	NOUN
bibechana-29750	84	17	using	use	VERB
bibechana-29750	84	18	charmm	charmm	PROPN
bibechana-29750	84	19	force	force	NOUN
bibechana-29750	84	20	field	field	NOUN
bibechana-29750	84	21	(	(	PUNCT
bibechana-29750	84	22	charmm	charmm	NOUN
bibechana-29750	84	23	36	36	NUM
bibechana-29750	84	24	)	)	PUNCT
bibechana-29750	84	25	under	under	ADP
bibechana-29750	84	26	following	follow	VERB
bibechana-29750	84	27	parameters	parameter	NOUN
bibechana-29750	84	28	:	:	PUNCT
bibechana-29750	84	29	a	a	DET
bibechana-29750	84	30	system	system	NOUN
bibechana-29750	84	31	of	of	ADP
bibechana-29750	84	32	oxygenated	oxygenated	ADJ
bibechana-29750	84	33	hemoglobin	hemoglobin	NOUN
bibechana-29750	84	34	protein	protein	NOUN
bibechana-29750	84	35	(	(	PUNCT
bibechana-29750	84	36	a3n	a3n	PROPN
bibechana-29750	84	37	)	)	PUNCT
bibechana-29750	84	38	with	with	ADP
bibechana-29750	84	39	4546(without	4546(without	NUM
bibechana-29750	84	40	water	water	NOUN
bibechana-29750	84	41	)	)	PUNCT
bibechana-29750	84	42	atoms	atom	NOUN
bibechana-29750	84	43	under	under	ADP
bibechana-29750	84	44	the	the	DET
bibechana-29750	84	45	interaction	interaction	NOUN
bibechana-29750	84	46	of	of	ADP
bibechana-29750	84	47	the	the	DET
bibechana-29750	84	48	bond	bond	NOUN
bibechana-29750	84	49	potential	potential	NOUN
bibechana-29750	84	50	and	and	CCONJ
bibechana-29750	84	51	nonjhulan	nonjhulan	PROPN
bibechana-29750	84	52	powrel	powrel	PROPN
bibechana-29750	84	53	,	,	PUNCT
bibechana-29750	84	54	narayan	narayan	PROPN
bibechana-29750	85	1	p.	p.	NOUN
bibechana-29750	85	2	adhikari/	adhikari/	NUM
bibechana-29750	85	3	bibechana	bibechana	NOUN
bibechana-29750	85	4	18	18	NUM
bibechana-29750	85	5	(	(	PUNCT
bibechana-29750	85	6	1)(2021	1)(2021	NUM
bibechana-29750	85	7	)	)	PUNCT
bibechana-29750	85	8	140	140	NUM
bibechana-29750	85	9	-	-	SYM
bibechana-29750	85	10	148	148	NUM
bibechana-29750	85	11	144	144	NUM
bibechana-29750	85	12	bonded	bond	VERB
bibechana-29750	85	13	potential	potential	NOUN
bibechana-29750	85	14	inside	inside	ADP
bibechana-29750	85	15	a	a	DET
bibechana-29750	85	16	box	box	NOUN
bibechana-29750	85	17	with	with	ADP
bibechana-29750	85	18	cut	cut	VERB
bibechana-29750	85	19	off	off	ADP
bibechana-29750	85	20	distance	distance	NOUN
bibechana-29750	85	21	of	of	ADP
bibechana-29750	85	22	12.0	12.0	NUM
bibechana-29750	85	23	å	å	NOUN
bibechana-29750	85	24	,	,	PUNCT
bibechana-29750	85	25	pressure	pressure	NOUN
bibechana-29750	85	26	of	of	ADP
bibechana-29750	85	27	1	1	NUM
bibechana-29750	85	28	bar	bar	NOUN
bibechana-29750	85	29	and	and	CCONJ
bibechana-29750	85	30	temperature	temperature	NOUN
bibechana-29750	85	31	310	310	NUM
bibechana-29750	85	32	k.	k.	NOUN
bibechana-29750	85	33	a	a	DET
bibechana-29750	85	34	system	system	NOUN
bibechana-29750	85	35	of	of	ADP
bibechana-29750	85	36	oxygenated	oxygenated	ADJ
bibechana-29750	85	37	hemoglobin	hemoglobin	NOUN
bibechana-29750	85	38	protein(e83	protein(e83	PROPN
bibechana-29750	85	39	)	)	PUNCT
bibechana-29750	85	40	with	with	ADP
bibechana-29750	85	41	19167(without	19167(without	NUM
bibechana-29750	85	42	water	water	NOUN
bibechana-29750	85	43	is	be	AUX
bibechana-29750	85	44	4668	4668	NUM
bibechana-29750	85	45	)	)	PUNCT
bibechana-29750	85	46	atoms	atom	NOUN
bibechana-29750	85	47	under	under	ADP
bibechana-29750	85	48	the	the	DET
bibechana-29750	85	49	interaction	interaction	NOUN
bibechana-29750	85	50	of	of	ADP
bibechana-29750	85	51	the	the	DET
bibechana-29750	85	52	bond	bond	NOUN
bibechana-29750	85	53	potential	potential	NOUN
bibechana-29750	85	54	and	and	CCONJ
bibechana-29750	85	55	non	non	ADJ
bibechana-29750	85	56	-	-	ADJ
bibechana-29750	85	57	bonded	bonded	ADJ
bibechana-29750	85	58	potential	potential	NOUN
bibechana-29750	85	59	inside	inside	ADP
bibechana-29750	85	60	a	a	DET
bibechana-29750	85	61	box	box	NOUN
bibechana-29750	85	62	with	with	ADP
bibechana-29750	85	63	cut	cut	VERB
bibechana-29750	85	64	off	off	ADP
bibechana-29750	85	65	distance	distance	NOUN
bibechana-29750	85	66	of	of	ADP
bibechana-29750	85	67	12.0	12.0	NUM
bibechana-29750	85	68	å	å	NOUN
bibechana-29750	85	69	,	,	PUNCT
bibechana-29750	85	70	pressure	pressure	NOUN
bibechana-29750	85	71	of	of	ADP
bibechana-29750	85	72	1	1	NUM
bibechana-29750	85	73	bar	bar	NOUN
bibechana-29750	85	74	and	and	CCONJ
bibechana-29750	85	75	temperature	temperature	NOUN
bibechana-29750	85	76	310	310	NUM
bibechana-29750	85	77	k.	k.	NOUN
bibechana-29750	85	78	a	a	DET
bibechana-29750	85	79	system	system	NOUN
bibechana-29750	85	80	of	of	ADP
bibechana-29750	85	81	oxygenated	oxygenated	ADJ
bibechana-29750	85	82	hemoglobin	hemoglobin	NOUN
bibechana-29750	85	83	protein(uvx	protein(uvx	PROPN
bibechana-29750	85	84	)	)	PUNCT
bibechana-29750	85	85	with	with	ADP
bibechana-29750	85	86	1863	1863	NUM
bibechana-29750	85	87	atoms	atom	NOUN
bibechana-29750	85	88	under	under	ADP
bibechana-29750	85	89	the	the	DET
bibechana-29750	85	90	interaction	interaction	NOUN
bibechana-29750	85	91	of	of	ADP
bibechana-29750	85	92	the	the	DET
bibechana-29750	85	93	bond	bond	NOUN
bibechana-29750	85	94	potential	potential	NOUN
bibechana-29750	85	95	and	and	CCONJ
bibechana-29750	85	96	nonbonded	nonbonde	VERB
bibechana-29750	85	97	potential	potential	NOUN
bibechana-29750	85	98	inside	inside	ADP
bibechana-29750	85	99	a	a	DET
bibechana-29750	85	100	box	box	NOUN
bibechana-29750	85	101	with	with	ADP
bibechana-29750	85	102	cut	cut	VERB
bibechana-29750	85	103	off	off	ADP
bibechana-29750	85	104	distance	distance	NOUN
bibechana-29750	85	105	of	of	ADP
bibechana-29750	85	106	12.0	12.0	NUM
bibechana-29750	85	107	å	å	NOUN
bibechana-29750	85	108	,	,	PUNCT
bibechana-29750	85	109	pressure	pressure	NOUN
bibechana-29750	85	110	of	of	ADP
bibechana-29750	85	111	1	1	NUM
bibechana-29750	85	112	bar	bar	NOUN
bibechana-29750	85	113	and	and	CCONJ
bibechana-29750	85	114	temperature	temperature	NOUN
bibechana-29750	85	115	310	310	NUM
bibechana-29750	85	116	k.	k.	NOUN
bibechana-29750	85	117	similarly	similarly	ADV
bibechana-29750	85	118	,	,	PUNCT
bibechana-29750	85	119	for	for	ADP
bibechana-29750	85	120	other	other	ADJ
bibechana-29750	85	121	three	three	NUM
bibechana-29750	85	122	systems	system	NOUN
bibechana-29750	85	123	of	of	ADP
bibechana-29750	85	124	sickle	sickle	NOUN
bibechana-29750	85	125	hemoglobin	hemoglobin	NOUN
bibechana-29750	85	126	protein(hbs	protein(hbs	NOUN
bibechana-29750	85	127	)	)	PUNCT
bibechana-29750	85	128	there	there	PRON
bibechana-29750	85	129	are	be	VERB
bibechana-29750	85	130	9112	9112	NUM
bibechana-29750	85	131	atoms	atom	NOUN
bibechana-29750	85	132	in	in	ADP
bibechana-29750	85	133	each	each	PRON
bibechana-29750	85	134	and	and	CCONJ
bibechana-29750	85	135	interacting	interact	VERB
bibechana-29750	85	136	at	at	ADP
bibechana-29750	85	137	the	the	DET
bibechana-29750	85	138	same	same	ADJ
bibechana-29750	85	139	potential	potential	NOUN
bibechana-29750	85	140	as	as	ADP
bibechana-29750	85	141	before	before	ADV
bibechana-29750	85	142	with	with	ADP
bibechana-29750	85	143	pressure	pressure	NOUN
bibechana-29750	85	144	at	at	ADP
bibechana-29750	85	145	1	1	NUM
bibechana-29750	85	146	bar	bar	NOUN
bibechana-29750	85	147	,	,	PUNCT
bibechana-29750	85	148	cut	cut	VERB
bibechana-29750	85	149	off	off	ADP
bibechana-29750	85	150	distance	distance	NOUN
bibechana-29750	85	151	of	of	ADP
bibechana-29750	85	152	12.0	12.0	NUM
bibechana-29750	85	153	å	å	PROPN
bibechana-29750	85	154	and	and	CCONJ
bibechana-29750	85	155	at	at	ADP
bibechana-29750	85	156	temperatures	temperature	NOUN
bibechana-29750	85	157	of	of	ADP
bibechana-29750	85	158	305	305	NUM
bibechana-29750	85	159	k	k	NOUN
bibechana-29750	85	160	,	,	PUNCT
bibechana-29750	85	161	310	310	NUM
bibechana-29750	85	162	k	k	NOUN
bibechana-29750	85	163	and	and	CCONJ
bibechana-29750	85	164	315	315	NUM
bibechana-29750	85	165	k.	k.	NOUN
bibechana-29750	85	166	after	after	ADP
bibechana-29750	85	167	equilibration	equilibration	NOUN
bibechana-29750	85	168	of	of	ADP
bibechana-29750	85	169	all	all	DET
bibechana-29750	85	170	the	the	DET
bibechana-29750	85	171	above	above	ADJ
bibechana-29750	85	172	six	six	NUM
bibechana-29750	85	173	system	system	NOUN
bibechana-29750	85	174	they	they	PRON
bibechana-29750	85	175	are	be	AUX
bibechana-29750	85	176	energetically	energetically	ADV
bibechana-29750	85	177	minimized	minimize	VERB
bibechana-29750	85	178	at	at	ADP
bibechana-29750	85	179	their	their	PRON
bibechana-29750	85	180	corresponding	corresponding	ADJ
bibechana-29750	85	181	constant	constant	ADJ
bibechana-29750	85	182	temperature	temperature	NOUN
bibechana-29750	85	183	which	which	PRON
bibechana-29750	85	184	provides	provide	VERB
bibechana-29750	85	185	their	their	PRON
bibechana-29750	85	186	rmsd	rmsd	ADJ
bibechana-29750	85	187	values	value	NOUN
bibechana-29750	85	188	.	.	PUNCT
bibechana-29750	86	1	at	at	ADP
bibechana-29750	86	2	last	last	ADJ
bibechana-29750	86	3	systems	system	NOUN
bibechana-29750	86	4	are	be	AUX
bibechana-29750	86	5	further	far	ADV
bibechana-29750	86	6	modified	modify	VERB
bibechana-29750	86	7	for	for	ADP
bibechana-29750	86	8	nve	nve	NOUN
bibechana-29750	86	9	and	and	CCONJ
bibechana-29750	86	10	nvt	nvt	PROPN
bibechana-29750	86	11	simulation	simulation	NOUN
bibechana-29750	86	12	run	run	VERB
bibechana-29750	86	13	in	in	ADP
bibechana-29750	86	14	which	which	PRON
bibechana-29750	86	15	we	we	PRON
bibechana-29750	86	16	use	use	VERB
bibechana-29750	86	17	the	the	DET
bibechana-29750	86	18	temperature	temperature	NOUN
bibechana-29750	86	19	coupling	coupling	NOUN
bibechana-29750	86	20	feature	feature	NOUN
bibechana-29750	86	21	of	of	ADP
bibechana-29750	86	22	namd	namd	NOUN
bibechana-29750	86	23	to	to	PART
bibechana-29750	86	24	set	set	VERB
bibechana-29750	86	25	the	the	DET
bibechana-29750	86	26	temperature	temperature	NOUN
bibechana-29750	86	27	of	of	ADP
bibechana-29750	86	28	the	the	DET
bibechana-29750	86	29	molecules	molecule	NOUN
bibechana-29750	86	30	in	in	ADP
bibechana-29750	86	31	the	the	DET
bibechana-29750	86	32	outer	outer	ADJ
bibechana-29750	86	33	layer	layer	NOUN
bibechana-29750	86	34	of	of	ADP
bibechana-29750	86	35	the	the	DET
bibechana-29750	86	36	sphere	sphere	NOUN
bibechana-29750	86	37	to	to	ADP
bibechana-29750	86	38	300	300	NUM
bibechana-29750	86	39	k	k	NOUN
bibechana-29750	86	40	,	,	PUNCT
bibechana-29750	86	41	while	while	SCONJ
bibechana-29750	86	42	the	the	DET
bibechana-29750	86	43	rest	rest	NOUN
bibechana-29750	86	44	of	of	ADP
bibechana-29750	86	45	the	the	DET
bibechana-29750	86	46	bob	bob	NOUN
bibechana-29750	86	47	is	be	AUX
bibechana-29750	86	48	set	set	VERB
bibechana-29750	86	49	to	to	ADP
bibechana-29750	86	50	temperature	temperature	NOUN
bibechana-29750	86	51	of	of	ADP
bibechana-29750	86	52	330	330	NUM
bibechana-29750	86	53	k.	k.	NOUN
bibechana-29750	86	54	4	4	NUM
bibechana-29750	86	55	.	.	NOUN
bibechana-29750	86	56	result	result	NOUN
bibechana-29750	86	57	and	and	CCONJ
bibechana-29750	86	58	discussion	discussion	NOUN
bibechana-29750	86	59	present	present	ADJ
bibechana-29750	86	60	work	work	NOUN
bibechana-29750	86	61	was	be	AUX
bibechana-29750	86	62	to	to	PART
bibechana-29750	86	63	study	study	VERB
bibechana-29750	86	64	the	the	DET
bibechana-29750	86	65	rmsd	rmsd	NOUN
bibechana-29750	86	66	as	as	ADV
bibechana-29750	86	67	well	well	ADV
bibechana-29750	86	68	as	as	ADP
bibechana-29750	86	69	specific	specific	ADJ
bibechana-29750	86	70	heat	heat	NOUN
bibechana-29750	86	71	capacity	capacity	NOUN
bibechana-29750	86	72	of	of	ADP
bibechana-29750	86	73	normal	normal	ADJ
bibechana-29750	86	74	and	and	CCONJ
bibechana-29750	86	75	sickle	sickle	ADJ
bibechana-29750	86	76	hemoglobin	hemoglobin	NOUN
bibechana-29750	86	77	protein	protein	NOUN
bibechana-29750	86	78	.	.	PUNCT
bibechana-29750	87	1	the	the	DET
bibechana-29750	87	2	rmsd	rmsd	NOUN
bibechana-29750	87	3	was	be	AUX
bibechana-29750	87	4	calculated	calculate	VERB
bibechana-29750	87	5	using	use	VERB
bibechana-29750	87	6	the	the	DET
bibechana-29750	87	7	equation	equation	NOUN
bibechana-29750	87	8	(	(	PUNCT
bibechana-29750	87	9	9	9	NUM
bibechana-29750	87	10	)	)	PUNCT
bibechana-29750	87	11	.	.	PUNCT
bibechana-29750	88	1	we	we	PRON
bibechana-29750	88	2	plotted	plot	VERB
bibechana-29750	88	3	the	the	DET
bibechana-29750	88	4	rmsd	rmsd	NOUN
bibechana-29750	88	5	of	of	ADP
bibechana-29750	88	6	hemoglobin	hemoglobin	NOUN
bibechana-29750	88	7	protein	protein	NOUN
bibechana-29750	88	8	against	against	ADP
bibechana-29750	88	9	the	the	DET
bibechana-29750	88	10	time	time	NOUN
bibechana-29750	88	11	steps	step	NOUN
bibechana-29750	88	12	as	as	SCONJ
bibechana-29750	88	13	follows	follow	VERB
bibechana-29750	88	14	;	;	PUNCT
bibechana-29750	88	15	where	where	SCONJ
bibechana-29750	88	16	figure	figure	NOUN
bibechana-29750	88	17	3(a	3(a	NUM
bibechana-29750	88	18	)	)	PUNCT
bibechana-29750	88	19	and	and	CCONJ
bibechana-29750	88	20	3(b	3(b	NUM
bibechana-29750	88	21	)	)	PUNCT
bibechana-29750	88	22	indicates	indicate	VERB
bibechana-29750	88	23	the	the	DET
bibechana-29750	88	24	graph	graph	NOUN
bibechana-29750	88	25	of	of	ADP
bibechana-29750	88	26	root	root	NOUN
bibechana-29750	88	27	mean	mean	ADJ
bibechana-29750	88	28	square	square	ADJ
bibechana-29750	88	29	deviations	deviation	NOUN
bibechana-29750	88	30	of	of	ADP
bibechana-29750	88	31	oxygenated	oxygenated	ADJ
bibechana-29750	88	32	sickle	sickle	NOUN
bibechana-29750	88	33	hemoglobin	hemoglobin	NOUN
bibechana-29750	88	34	protein	protein	NOUN
bibechana-29750	88	35	and	and	CCONJ
bibechana-29750	88	36	de	de	ADJ
bibechana-29750	88	37	-	-	ADJ
bibechana-29750	88	38	oxygenated	oxygenated	ADJ
bibechana-29750	88	39	hemoglobin	hemoglobin	NOUN
bibechana-29750	88	40	protein	protein	NOUN
bibechana-29750	88	41	at	at	ADP
bibechana-29750	88	42	temperature	temperature	NOUN
bibechana-29750	88	43	of	of	ADP
bibechana-29750	88	44	310	310	NUM
bibechana-29750	88	45	k	k	NOUN
bibechana-29750	88	46	and	and	CCONJ
bibechana-29750	88	47	obtained	obtain	VERB
bibechana-29750	88	48	the	the	DET
bibechana-29750	88	49	rmsd	rmsd	NOUN
bibechana-29750	88	50	as	as	ADP
bibechana-29750	88	51	0.8	0.8	NUM
bibechana-29750	88	52	å	å	PROPN
bibechana-29750	88	53	and	and	CCONJ
bibechana-29750	88	54	1.25	1.25	NUM
bibechana-29750	88	55	å	å	NOUN
bibechana-29750	88	56	respectively	respectively	ADV
bibechana-29750	88	57	.	.	PUNCT
bibechana-29750	89	1	they	they	PRON
bibechana-29750	89	2	were	be	AUX
bibechana-29750	89	3	found	find	VERB
bibechana-29750	89	4	to	to	PART
bibechana-29750	89	5	be	be	AUX
bibechana-29750	89	6	inc	inc	PROPN
bibechana-29750	89	7	reased	rease	VERB
bibechana-29750	89	8	initially	initially	ADV
bibechana-29750	89	9	with	with	ADP
bibechana-29750	89	10	small	small	ADJ
bibechana-29750	89	11	fluctuation	fluctuation	NOUN
bibechana-29750	89	12	and	and	CCONJ
bibechana-29750	89	13	then	then	ADV
bibechana-29750	89	14	remain	remain	VERB
bibechana-29750	89	15	constant	constant	ADJ
bibechana-29750	89	16	for	for	ADP
bibechana-29750	89	17	both	both	PRON
bibechana-29750	89	18	at	at	ADP
bibechana-29750	89	19	various	various	ADJ
bibechana-29750	89	20	values	value	NOUN
bibechana-29750	89	21	,	,	PUNCT
bibechana-29750	89	22	i.e.	i.e.	X
bibechana-29750	89	23	the	the	DET
bibechana-29750	89	24	rmsd	rmsd	NOUN
bibechana-29750	89	25	of	of	ADP
bibechana-29750	89	26	deoxygenated	deoxygenate	VERB
bibechana-29750	89	27	hemoglobin	hemoglobin	NOUN
bibechana-29750	89	28	found	find	VERB
bibechana-29750	89	29	to	to	PART
bibechana-29750	89	30	be	be	AUX
bibechana-29750	89	31	higher	high	ADJ
bibechana-29750	89	32	than	than	ADP
bibechana-29750	89	33	of	of	ADP
bibechana-29750	89	34	oxygenated	oxygenated	ADJ
bibechana-29750	89	35	sickle	sickle	PROPN
bibechana-29750	89	36	hemoglobin	hemoglobin	PROPN
bibechana-29750	89	37	protein	protein	NOUN
bibechana-29750	89	38	.	.	PUNCT
bibechana-29750	90	1	rmsd	rmsd	PROPN
bibechana-29750	90	2	plot	plot	NOUN
bibechana-29750	90	3	of	of	ADP
bibechana-29750	90	4	other	other	ADJ
bibechana-29750	90	5	system	system	NOUN
bibechana-29750	90	6	of	of	ADP
bibechana-29750	90	7	hemoglobin	hemoglobin	NOUN
bibechana-29750	90	8	protein	protein	NOUN
bibechana-29750	90	9	were	be	AUX
bibechana-29750	90	10	also	also	ADV
bibechana-29750	90	11	plotted	plot	VERB
bibechana-29750	90	12	where	where	SCONJ
bibechana-29750	90	13	figure	figure	NOUN
bibechana-29750	90	14	4(a	4(a	NUM
bibechana-29750	90	15	)	)	PUNCT
bibechana-29750	90	16	and	and	CCONJ
bibechana-29750	90	17	4(b	4(b	NUM
bibechana-29750	90	18	)	)	PUNCT
bibechana-29750	90	19	indicates	indicate	VERB
bibechana-29750	90	20	the	the	DET
bibechana-29750	90	21	root	root	NOUN
bibechana-29750	90	22	mean	mean	NOUN
bibechana-29750	90	23	square	square	ADJ
bibechana-29750	90	24	deviations	deviation	NOUN
bibechana-29750	90	25	of	of	ADP
bibechana-29750	90	26	oxygenated	oxygenated	ADJ
bibechana-29750	90	27	hemoglobin	hemoglobin	NOUN
bibechana-29750	90	28	protein	protein	NOUN
bibechana-29750	90	29	and	and	CCONJ
bibechana-29750	90	30	sickle	sickle	NOUN
bibechana-29750	90	31	hemoglobin	hemoglobin	NOUN
bibechana-29750	90	32	protein	protein	NOUN
bibechana-29750	90	33	at	at	ADP
bibechana-29750	90	34	temperature	temperature	NOUN
bibechana-29750	90	35	of	of	ADP
bibechana-29750	90	36	310	310	NUM
bibechana-29750	90	37	k.	k.	NOUN
bibechana-29750	90	38	for	for	ADP
bibechana-29750	90	39	which	which	PRON
bibechana-29750	90	40	the	the	DET
bibechana-29750	90	41	rmsd	rmsd	NOUN
bibechana-29750	90	42	found	find	VERB
bibechana-29750	90	43	to	to	PART
bibechana-29750	90	44	be	be	AUX
bibechana-29750	90	45	increased	increase	VERB
bibechana-29750	90	46	initially	initially	ADV
bibechana-29750	90	47	with	with	ADP
bibechana-29750	90	48	small	small	ADJ
bibechana-29750	90	49	fluctuation	fluctuation	NOUN
bibechana-29750	90	50	and	and	CCONJ
bibechana-29750	90	51	then	then	ADV
bibechana-29750	90	52	remain	remain	VERB
bibechana-29750	90	53	constant	constant	ADJ
bibechana-29750	90	54	for	for	ADP
bibechana-29750	90	55	both	both	PRON
bibechana-29750	90	56	at	at	ADP
bibechana-29750	90	57	various	various	ADJ
bibechana-29750	90	58	values	value	NOUN
bibechana-29750	90	59	of	of	ADP
bibechana-29750	90	60	1.3	1.3	NUM
bibechana-29750	90	61	å	å	NOUN
bibechana-29750	90	62	and	and	CCONJ
bibechana-29750	90	63	0.75	0.75	NUM
bibechana-29750	90	64	å	å	PROPN
bibechana-29750	90	65	respectively	respectively	ADV
bibechana-29750	90	66	,	,	PUNCT
bibechana-29750	90	67	i.e.	i.e.	X
bibechana-29750	90	68	the	the	DET
bibechana-29750	90	69	rmsd	rmsd	NOUN
bibechana-29750	90	70	of	of	ADP
bibechana-29750	90	71	oxygenated	oxygenated	ADJ
bibechana-29750	90	72	hemoglobin	hemoglobin	NOUN
bibechana-29750	90	73	is	be	AUX
bibechana-29750	90	74	higher	high	ADJ
bibechana-29750	90	75	than	than	ADP
bibechana-29750	90	76	of	of	ADP
bibechana-29750	90	77	sickle	sickle	NOUN
bibechana-29750	90	78	hemoglobin	hemoglobin	NOUN
bibechana-29750	90	79	protein	protein	NOUN
bibechana-29750	90	80	.	.	PUNCT
bibechana-29750	91	1	similarly	similarly	ADV
bibechana-29750	91	2	,	,	PUNCT
bibechana-29750	91	3	rmsd	rmsd	VERB
bibechana-29750	91	4	for	for	ADP
bibechana-29750	91	5	sickle	sickle	NOUN
bibechana-29750	91	6	hemoglobin	hemoglobin	NOUN
bibechana-29750	91	7	protein	protein	NOUN
bibechana-29750	91	8	at	at	ADP
bibechana-29750	91	9	various	various	ADJ
bibechana-29750	91	10	temperatures	temperature	NOUN
bibechana-29750	91	11	were	be	AUX
bibechana-29750	91	12	studied	study	VERB
bibechana-29750	91	13	,	,	PUNCT
bibechana-29750	91	14	where	where	SCONJ
bibechana-29750	91	15	figure	figure	NOUN
bibechana-29750	91	16	5(a	5(a	NUM
bibechana-29750	91	17	)	)	PUNCT
bibechana-29750	91	18	and	and	CCONJ
bibechana-29750	91	19	5(b	5(b	NUM
bibechana-29750	91	20	)	)	PUNCT
bibechana-29750	91	21	indicating	indicate	VERB
bibechana-29750	91	22	the	the	DET
bibechana-29750	91	23	root	root	NOUN
bibechana-29750	91	24	mean	mean	NOUN
bibechana-29750	91	25	square	square	ADJ
bibechana-29750	91	26	deviations	deviation	NOUN
bibechana-29750	91	27	of	of	ADP
bibechana-29750	91	28	sickle	sickle	NOUN
bibechana-29750	91	29	hemoglobin	hemoglobin	NOUN
bibechana-29750	91	30	protein	protein	NOUN
bibechana-29750	91	31	at	at	ADP
bibechana-29750	91	32	305	305	NUM
bibechana-29750	91	33	k	k	NOUN
bibechana-29750	91	34	and	and	CCONJ
bibechana-29750	91	35	315	315	NUM
bibechana-29750	91	36	k	k	NOUN
bibechana-29750	91	37	respectively	respectively	ADV
bibechana-29750	91	38	.	.	PUNCT
bibechana-29750	92	1	they	they	PRON
bibechana-29750	92	2	are	be	AUX
bibechana-29750	92	3	increased	increase	VERB
bibechana-29750	92	4	initially	initially	ADV
bibechana-29750	92	5	with	with	ADP
bibechana-29750	92	6	small	small	ADJ
bibechana-29750	92	7	fluctuation	fluctuation	NOUN
bibechana-29750	92	8	and	and	CCONJ
bibechana-29750	92	9	then	then	ADV
bibechana-29750	92	10	remain	remain	VERB
bibechana-29750	92	11	constant	constant	ADJ
bibechana-29750	92	12	for	for	ADP
bibechana-29750	92	13	both	both	PRON
bibechana-29750	92	14	at	at	ADP
bibechana-29750	92	15	various	various	ADJ
bibechana-29750	92	16	values	value	NOUN
bibechana-29750	92	17	of	of	ADP
bibechana-29750	92	18	1.5	1.5	NUM
bibechana-29750	92	19	å	å	NOUN
bibechana-29750	92	20	and	and	CCONJ
bibechana-29750	92	21	1.4	1.4	NUM
bibechana-29750	92	22	å	å	NOUN
bibechana-29750	92	23	respectively	respectively	ADV
bibechana-29750	92	24	i.e.	i.e.	X
bibechana-29750	92	25	the	the	DET
bibechana-29750	92	26	rmsd	rmsd	NOUN
bibechana-29750	92	27	of	of	ADP
bibechana-29750	92	28	sickle	sickle	NOUN
bibechana-29750	92	29	hemoglobin	hemoglobin	NOUN
bibechana-29750	92	30	protein	protein	NOUN
bibechana-29750	92	31	at	at	ADP
bibechana-29750	92	32	lower	low	ADJ
bibechana-29750	92	33	temperature	temperature	NOUN
bibechana-29750	92	34	is	be	AUX
bibechana-29750	92	35	higher	high	ADJ
bibechana-29750	92	36	than	than	ADP
bibechana-29750	92	37	of	of	ADP
bibechana-29750	92	38	sickle	sickle	NOUN
bibechana-29750	92	39	hemoglobin	hemoglobin	NOUN
bibechana-29750	92	40	protein	protein	NOUN
bibechana-29750	92	41	at	at	ADP
bibechana-29750	92	42	higher	high	ADJ
bibechana-29750	92	43	temperature	temperature	NOUN
bibechana-29750	92	44	.	.	PUNCT
bibechana-29750	93	1	the	the	DET
bibechana-29750	93	2	above	above	ADJ
bibechana-29750	93	3	figure	figure	NOUN
bibechana-29750	93	4	3(a	3(a	NUM
bibechana-29750	93	5	)	)	PUNCT
bibechana-29750	93	6	,	,	PUNCT
bibechana-29750	93	7	3(b	3(b	NUM
bibechana-29750	93	8	)	)	PUNCT
bibechana-29750	93	9	,	,	PUNCT
bibechana-29750	93	10	4(a	4(a	NUM
bibechana-29750	93	11	)	)	PUNCT
bibechana-29750	93	12	and	and	CCONJ
bibechana-29750	93	13	5(a	5(a	NUM
bibechana-29750	93	14	)	)	PUNCT
bibechana-29750	93	15	,	,	PUNCT
bibechana-29750	93	16	are	be	AUX
bibechana-29750	93	17	the	the	DET
bibechana-29750	93	18	rmsd	rmsd	NOUN
bibechana-29750	93	19	graph	graph	NOUN
bibechana-29750	93	20	at	at	ADP
bibechana-29750	93	21	310	310	NUM
bibechana-29750	93	22	k	k	NOUN
bibechana-29750	93	23	for	for	ADP
bibechana-29750	93	24	carbon	carbon	NOUN
bibechana-29750	93	25	monoxy	monoxy	NOUN
bibechana-29750	93	26	-	-	PUNCT
bibechana-29750	93	27	hemoglobin(s	hemoglobin(s	NOUN
bibechana-29750	93	28	)	)	PUNCT
bibechana-29750	93	29	,	,	PUNCT
bibechana-29750	93	30	deoxygenated	deoxygenate	VERB
bibechana-29750	93	31	hemoglobin	hemoglobin	NOUN
bibechana-29750	93	32	protein	protein	NOUN
bibechana-29750	93	33	,	,	PUNCT
bibechana-29750	93	34	truncated	truncate	VERB
bibechana-29750	93	35	heme	heme	NOUN
bibechana-29750	93	36	-	-	PUNCT
bibechana-29750	93	37	ligand	ligand	NOUN
bibechana-29750	93	38	hemoglobin	hemoglobin	NOUN
bibechana-29750	93	39	and	and	CCONJ
bibechana-29750	93	40	sickle	sickle	NOUN
bibechana-29750	93	41	hemoglobin	hemoglobin	NOUN
bibechana-29750	93	42	protein	protein	NOUN
bibechana-29750	93	43	respectively	respectively	ADV
bibechana-29750	93	44	.	.	PUNCT
bibechana-29750	94	1	correspondingly	correspondingly	ADV
bibechana-29750	94	2	their	their	PRON
bibechana-29750	94	3	rmsd	rmsd	NOUN
bibechana-29750	94	4	were	be	AUX
bibechana-29750	94	5	estimated	estimate	VERB
bibechana-29750	94	6	as	as	ADP
bibechana-29750	94	7	0.8	0.8	NUM
bibechana-29750	94	8	å	å	PROPN
bibechana-29750	94	9	,	,	PUNCT
bibechana-29750	94	10	1.2	1.2	NUM
bibechana-29750	94	11	å	å	NOUN
bibechana-29750	94	12	,	,	PUNCT
bibechana-29750	94	13	1.3	1.3	NUM
bibechana-29750	94	14	å	å	NOUN
bibechana-29750	94	15	and	and	CCONJ
bibechana-29750	94	16	0.75	0.75	NUM
bibechana-29750	94	17	å	å	PROPN
bibechana-29750	94	18	,	,	PUNCT
bibechana-29750	94	19	i.e.	i.e.	X
bibechana-29750	94	20	the	the	DET
bibechana-29750	94	21	rmsd	rmsd	NOUN
bibechana-29750	94	22	of	of	ADP
bibechana-29750	94	23	sickle	sickle	NOUN
bibechana-29750	94	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	94	25	is	be	AUX
bibechana-29750	94	26	least(0.75	least(0.75	PROPN
bibechana-29750	94	27	å	å	PROPN
bibechana-29750	94	28	)	)	PUNCT
bibechana-29750	94	29	and	and	CCONJ
bibechana-29750	94	30	of	of	ADP
bibechana-29750	94	31	truncated	truncated	ADJ
bibechana-29750	94	32	ligand	ligand	NOUN
bibechana-29750	94	33	hemoglobin	hemoglobin	NOUN
bibechana-29750	94	34	is	be	AUX
bibechana-29750	94	35	maximum(1.3	maximum(1.3	PROPN
bibechana-29750	94	36	å	å	PROPN
bibechana-29750	94	37	)	)	PUNCT
bibechana-29750	94	38	.	.	PUNCT
bibechana-29750	95	1	thus	thus	ADV
bibechana-29750	95	2	,	,	PUNCT
bibechana-29750	95	3	deoxygenated	deoxygenate	VERB
bibechana-29750	95	4	sickle	sickle	NOUN
bibechana-29750	95	5	hemoglobin	hemoglobin	NOUN
bibechana-29750	95	6	with	with	ADP
bibechana-29750	95	7	fibrous	fibrous	ADJ
bibechana-29750	95	8	nature	nature	NOUN
bibechana-29750	95	9	shows	show	VERB
bibechana-29750	95	10	least	least	ADJ
bibechana-29750	95	11	deviation	deviation	NOUN
bibechana-29750	95	12	from	from	ADP
bibechana-29750	95	13	the	the	DET
bibechana-29750	95	14	mean	mean	ADJ
bibechana-29750	95	15	position	position	NOUN
bibechana-29750	95	16	,	,	PUNCT
bibechana-29750	95	17	whereas	whereas	SCONJ
bibechana-29750	95	18	of	of	ADP
bibechana-29750	95	19	truncated	truncated	ADJ
bibechana-29750	95	20	ligand	ligand	NOUN
bibechana-29750	95	21	hemoglobin	hemoglobin	NOUN
bibechana-29750	95	22	with	with	ADP
bibechana-29750	95	23	large	large	ADJ
bibechana-29750	95	24	no	no	NOUN
bibechana-29750	95	25	of	of	ADP
bibechana-29750	95	26	hydrogen	hydrogen	NOUN
bibechana-29750	95	27	bond	bond	NOUN
bibechana-29750	95	28	and	and	CCONJ
bibechana-29750	95	29	hydrophobic	hydrophobic	NOUN
bibechana-29750	96	1	potential	potential	ADJ
bibechana-29750	96	2	move	move	NOUN
bibechana-29750	96	3	faster	fast	ADV
bibechana-29750	96	4	with	with	ADP
bibechana-29750	96	5	more	more	ADJ
bibechana-29750	96	6	rmsd	rmsd	NOUN
bibechana-29750	96	7	value	value	NOUN
bibechana-29750	96	8	.	.	PUNCT
bibechana-29750	97	1	similarly	similarly	ADV
bibechana-29750	97	2	normal	normal	ADJ
bibechana-29750	97	3	oxygenated	oxygenate	VERB
bibechana-29750	97	4	and	and	CCONJ
bibechana-29750	97	5	deoxygenated	deoxygenate	VERB
bibechana-29750	97	6	hemoglobin	hemoglobin	NOUN
bibechana-29750	97	7	jhulan	jhulan	PROPN
bibechana-29750	97	8	powrel	powrel	PROPN
bibechana-29750	97	9	,	,	PUNCT
bibechana-29750	97	10	narayan	narayan	PROPN
bibechana-29750	98	1	p.	p.	NOUN
bibechana-29750	98	2	adhikari/	adhikari/	NUM
bibechana-29750	98	3	bibechana	bibechana	NOUN
bibechana-29750	98	4	18	18	NUM
bibechana-29750	98	5	(	(	PUNCT
bibechana-29750	98	6	1)(2021	1)(2021	NUM
bibechana-29750	98	7	)	)	PUNCT
bibechana-29750	98	8	140	140	NUM
bibechana-29750	98	9	-	-	SYM
bibechana-29750	98	10	148	148	NUM
bibechana-29750	98	11	145	145	NUM
bibechana-29750	98	12	3	3	NUM
bibechana-29750	98	13	have	have	VERB
bibechana-29750	98	14	their	their	PRON
bibechana-29750	98	15	rmsd	rmsd	NOUN
bibechana-29750	98	16	1.3	1.3	NUM
bibechana-29750	98	17	å	å	NOUN
bibechana-29750	98	18	and	and	CCONJ
bibechana-29750	98	19	1.25	1.25	NUM
bibechana-29750	98	20	å	å	PROPN
bibechana-29750	98	21	respectively	respectively	ADV
bibechana-29750	98	22	which	which	PRON
bibechana-29750	98	23	are	be	AUX
bibechana-29750	98	24	higher	high	ADJ
bibechana-29750	98	25	than	than	ADP
bibechana-29750	98	26	both	both	CCONJ
bibechana-29750	98	27	the	the	DET
bibechana-29750	98	28	oxygenated	oxygenated	NOUN
bibechana-29750	98	29	(	(	PUNCT
bibechana-29750	98	30	0.8	0.8	NUM
bibechana-29750	98	31	å	å	NOUN
bibechana-29750	98	32	)	)	PUNCT
bibechana-29750	98	33	and	and	CCONJ
bibechana-29750	98	34	deoxygenated	deoxygenate	VERB
bibechana-29750	98	35	sickle	sickle	NOUN
bibechana-29750	98	36	hemoglobin	hemoglobin	NOUN
bibechana-29750	98	37	(	(	PUNCT
bibechana-29750	98	38	0.75	0.75	NUM
bibechana-29750	98	39	å	å	NOUN
bibechana-29750	98	40	)	)	PUNCT
bibechana-29750	98	41	.	.	PUNCT
bibechana-29750	99	1	again	again	ADV
bibechana-29750	99	2	at	at	ADP
bibechana-29750	99	3	temperatures	temperature	NOUN
bibechana-29750	99	4	of	of	ADP
bibechana-29750	99	5	305	305	NUM
bibechana-29750	99	6	k	k	NOUN
bibechana-29750	99	7	,	,	PUNCT
bibechana-29750	99	8	310	310	NUM
bibechana-29750	99	9	k	k	NOUN
bibechana-29750	99	10	and	and	CCONJ
bibechana-29750	99	11	315	315	NUM
bibechana-29750	99	12	k	k	NOUN
bibechana-29750	99	13	(	(	PUNCT
bibechana-29750	99	14	figure	figure	NOUN
bibechana-29750	99	15	4(b	4(b	NUM
bibechana-29750	99	16	)	)	PUNCT
bibechana-29750	99	17	,	,	PUNCT
bibechana-29750	99	18	5(a	5(a	NUM
bibechana-29750	99	19	)	)	PUNCT
bibechana-29750	99	20	and	and	CCONJ
bibechana-29750	99	21	figure.5	figure.5	PROPN
bibechana-29750	99	22	(	(	PUNCT
bibechana-29750	99	23	b	b	NOUN
bibechana-29750	99	24	)	)	PUNCT
bibechana-29750	99	25	)	)	PUNCT
bibechana-29750	99	26	of	of	ADP
bibechana-29750	99	27	deoxygenated	deoxygenate	VERB
bibechana-29750	99	28	sickle	sickle	NOUN
bibechana-29750	99	29	hemoglobin	hemoglobin	NOUN
bibechana-29750	99	30	(	(	PUNCT
bibechana-29750	99	31	hbs	hbs	PROPN
bibechana-29750	99	32	)	)	PUNCT
bibechana-29750	99	33	[	[	X
bibechana-29750	99	34	17	17	NUM
bibechana-29750	99	35	]	]	PUNCT
bibechana-29750	99	36	the	the	DET
bibechana-29750	99	37	rmsd	rmsd	NOUN
bibechana-29750	99	38	are	be	AUX
bibechana-29750	99	39	1.5	1.5	NUM
bibechana-29750	99	40	å	å	NOUN
bibechana-29750	99	41	,	,	PUNCT
bibechana-29750	99	42	0.75	0.75	NUM
bibechana-29750	99	43	å	å	PROPN
bibechana-29750	99	44	and	and	CCONJ
bibechana-29750	99	45	1.4	1.4	NUM
bibechana-29750	99	46	å	å	PROPN
bibechana-29750	99	47	respectively	respectively	ADV
bibechana-29750	99	48	.	.	PUNCT
bibechana-29750	100	1	figure	figure	NOUN
bibechana-29750	100	2	6(a	6(a	NUM
bibechana-29750	100	3	)	)	PUNCT
bibechana-29750	100	4	and	and	CCONJ
bibechana-29750	100	5	6(b	6(b	NUM
bibechana-29750	100	6	)	)	PUNCT
bibechana-29750	100	7	are	be	AUX
bibechana-29750	100	8	energy	energy	NOUN
bibechana-29750	100	9	fluctuation	fluctuation	NOUN
bibechana-29750	100	10	and	and	CCONJ
bibechana-29750	100	11	energy	energy	NOUN
bibechana-29750	100	12	distribution	distribution	NOUN
bibechana-29750	100	13	graph	graph	NOUN
bibechana-29750	100	14	during	during	ADP
bibechana-29750	100	15	nve	nve	NOUN
bibechana-29750	100	16	and	and	CCONJ
bibechana-29750	100	17	nvt	nvt	PROPN
bibechana-29750	100	18	run	run	NOUN
bibechana-29750	100	19	.	.	PUNCT
bibechana-29750	101	1	they	they	PRON
bibechana-29750	101	2	gives	give	VERB
bibechana-29750	101	3	the	the	DET
bibechana-29750	101	4	energy	energy	NOUN
bibechana-29750	101	5	deviation	deviation	NOUN
bibechana-29750	101	6	from	from	ADP
bibechana-29750	101	7	the	the	DET
bibechana-29750	101	8	mean	mean	NOUN
bibechana-29750	102	1	[	[	X
bibechana-29750	102	2	fig	fig	NOUN
bibechana-29750	102	3	6(a	6(a	NUM
bibechana-29750	102	4	)	)	PUNCT
bibechana-29750	102	5	]	]	PUNCT
bibechana-29750	102	6	and	and	CCONJ
bibechana-29750	102	7	energy	energy	NOUN
bibechana-29750	102	8	distribution	distribution	NOUN
bibechana-29750	102	9	pattern	pattern	NOUN
bibechana-29750	102	10	[	[	X
bibechana-29750	102	11	fig	fig	NOUN
bibechana-29750	102	12	6(b	6(b	NUM
bibechana-29750	102	13	)	)	PUNCT
bibechana-29750	102	14	]	]	PUNCT
bibechana-29750	102	15	i.e.	i.e.	X
bibechana-29750	102	16	more	more	ADJ
bibechana-29750	102	17	the	the	DET
bibechana-29750	102	18	energy	energy	NOUN
bibechana-29750	102	19	more	more	ADJ
bibechana-29750	102	20	is	be	AUX
bibechana-29750	102	21	the	the	DET
bibechana-29750	102	22	velocity	velocity	NOUN
bibechana-29750	102	23	as	as	ADV
bibechana-29750	102	24	well	well	ADV
bibechana-29750	102	25	as	as	ADP
bibechana-29750	102	26	temperature	temperature	NOUN
bibechana-29750	102	27	of	of	ADP
bibechana-29750	102	28	the	the	DET
bibechana-29750	102	29	system	system	NOUN
bibechana-29750	102	30	of	of	ADP
bibechana-29750	102	31	particles	particle	NOUN
bibechana-29750	102	32	and	and	CCONJ
bibechana-29750	102	33	hence	hence	ADV
bibechana-29750	102	34	system	system	NOUN
bibechana-29750	102	35	of	of	ADP
bibechana-29750	102	36	protein	protein	NOUN
bibechana-29750	102	37	behaving	behave	VERB
bibechana-29750	102	38	as	as	ADP
bibechana-29750	102	39	thermometer	thermometer	NOUN
bibechana-29750	102	40	.	.	PUNCT
bibechana-29750	103	1	computationally	computationally	ADV
bibechana-29750	103	2	by	by	ADP
bibechana-29750	103	3	using	use	VERB
bibechana-29750	103	4	namd	namd	ADJ
bibechana-29750	103	5	code	code	NOUN
bibechana-29750	103	6	the	the	DET
bibechana-29750	103	7	average	average	NOUN
bibechana-29750	103	8	of	of	ADP
bibechana-29750	103	9	square	square	NOUN
bibechana-29750	103	10	of	of	ADP
bibechana-29750	103	11	the	the	DET
bibechana-29750	103	12	total	total	ADJ
bibechana-29750	103	13	energies	energy	NOUN
bibechana-29750	103	14	and	and	CCONJ
bibechana-29750	103	15	square	square	NOUN
bibechana-29750	103	16	of	of	ADP
bibechana-29750	103	17	the	the	DET
bibechana-29750	103	18	average	average	ADJ
bibechana-29750	103	19	total	total	ADJ
bibechana-29750	103	20	energy	energy	NOUN
bibechana-29750	103	21	of	of	ADP
bibechana-29750	103	22	de	de	ADJ
bibechana-29750	103	23	-	-	ADJ
bibechana-29750	103	24	oxygenated	oxygenated	ADJ
bibechana-29750	103	25	hemoglobin	hemoglobin	NOUN
bibechana-29750	103	26	protein(e83	protein(e83	PROPN
bibechana-29750	103	27	)	)	PUNCT
bibechana-29750	103	28	were	be	AUX
bibechana-29750	103	29	obtain	obtain	VERB
bibechana-29750	103	30	as	as	ADP
bibechana-29750	103	31	6722047.08	6722047.08	NUM
bibechana-29750	103	32	kcalmol−1	kcalmol−1	NOUN
bibechana-29750	103	33	and	and	CCONJ
bibechana-29750	103	34	6714152.23	6714152.23	NUM
bibechana-29750	103	35	kcalmol−1	kcalmol−1	NOUN
bibechana-29750	103	36	respectively	respectively	ADV
bibechana-29750	103	37	.	.	PUNCT
bibechana-29750	104	1	on	on	ADP
bibechana-29750	104	2	using	use	VERB
bibechana-29750	104	3	these	these	DET
bibechana-29750	104	4	values	value	NOUN
bibechana-29750	104	5	the	the	DET
bibechana-29750	104	6	specific	specific	ADJ
bibechana-29750	104	7	heat	heat	NOUN
bibechana-29750	104	8	capacity	capacity	NOUN
bibechana-29750	104	9	of	of	ADP
bibechana-29750	104	10	de	de	ADJ
bibechana-29750	104	11	-	-	ADJ
bibechana-29750	104	12	oxygenated	oxygenated	ADJ
bibechana-29750	104	13	hemoglobin	hemoglobin	NOUN
bibechana-29750	104	14	protein	protein	NOUN
bibechana-29750	104	15	was	be	AUX
bibechana-29750	104	16	estimated	estimate	VERB
bibechana-29750	104	17	as	as	ADP
bibechana-29750	104	18	2903	2903	NUM
bibechana-29750	104	19	jkg−1c−1	jkg−1c−1	PROPN
bibechana-29750	104	20	(	(	PUNCT
bibechana-29750	104	21	table	table	NOUN
bibechana-29750	104	22	1	1	NUM
bibechana-29750	104	23	)	)	PUNCT
bibechana-29750	104	24	.	.	PUNCT
bibechana-29750	105	1	now	now	ADV
bibechana-29750	105	2	for	for	ADP
bibechana-29750	105	3	the	the	DET
bibechana-29750	105	4	calculation	calculation	NOUN
bibechana-29750	105	5	of	of	ADP
bibechana-29750	105	6	specific	specific	ADJ
bibechana-29750	105	7	heat	heat	NOUN
bibechana-29750	105	8	capacity	capacity	NOUN
bibechana-29750	105	9	(	(	PUNCT
bibechana-29750	105	10	cv	cv	PROPN
bibechana-29750	105	11	)	)	PUNCT
bibechana-29750	105	12	,	,	PUNCT
bibechana-29750	105	13	we	we	PRON
bibechana-29750	105	14	have	have	AUX
bibechana-29750	105	15	used	use	VERB
bibechana-29750	105	16	the	the	DET
bibechana-29750	105	17	following	follow	VERB
bibechana-29750	105	18	theoretical	theoretical	ADJ
bibechana-29750	105	19	and	and	CCONJ
bibechana-29750	105	20	simulation	simulation	NOUN
bibechana-29750	105	21	parameters	parameter	NOUN
bibechana-29750	105	22	under	under	ADP
bibechana-29750	105	23	the	the	DET
bibechana-29750	105	24	assumption	assumption	NOUN
bibechana-29750	105	25	of	of	ADP
bibechana-29750	105	26	classical	classical	ADJ
bibechana-29750	105	27	molecular	molecular	ADJ
bibechana-29750	105	28	dynamics	dynamic	NOUN
bibechana-29750	105	29	:	:	PUNCT
bibechana-29750	105	30	kb=0.00198657	kb=0.00198657	PROPN
bibechana-29750	105	31	kcal	kcal	PROPN
bibechana-29750	105	32	/molk	/molk	PROPN
bibechana-29750	105	33	,	,	PUNCT
bibechana-29750	105	34	σ	σ	X
bibechana-29750	105	35	∼	∼	NOUN
bibechana-29750	105	36	8	8	NUM
bibechana-29750	105	37	k	k	NOUN
bibechana-29750	105	38	,	,	PUNCT
bibechana-29750	105	39	t=317	t=317	VERB
bibechana-29750	105	40	k	k	NOUN
bibechana-29750	105	41	,	,	PUNCT
bibechana-29750	105	42	j=1.43846	j=1.43846	PROPN
bibechana-29750	105	43	×1020	×1020	VERB
bibechana-29750	105	44	kcal	kcal	PROPN
bibechana-29750	105	45	/	/	SYM
bibechana-29750	105	46	mol	mol	PROPN
bibechana-29750	105	47	.	.	PUNCT
bibechana-29750	106	1	the	the	DET
bibechana-29750	106	2	specific	specific	ADJ
bibechana-29750	106	3	heat	heat	NOUN
bibechana-29750	106	4	capacity	capacity	NOUN
bibechana-29750	106	5	of	of	ADP
bibechana-29750	106	6	normal	normal	ADJ
bibechana-29750	106	7	and	and	CCONJ
bibechana-29750	106	8	sickle	sickle	NOUN
bibechana-29750	106	9	hemoglobin	hemoglobin	NOUN
bibechana-29750	106	10	protein	protein	NOUN
bibechana-29750	106	11	were	be	AUX
bibechana-29750	106	12	calculated	calculate	VERB
bibechana-29750	106	13	by	by	ADP
bibechana-29750	106	14	using	use	VERB
bibechana-29750	106	15	the	the	DET
bibechana-29750	106	16	equation	equation	NOUN
bibechana-29750	106	17	(	(	PUNCT
bibechana-29750	106	18	11	11	NUM
bibechana-29750	106	19	)	)	PUNCT
bibechana-29750	106	20	and	and	CCONJ
bibechana-29750	106	21	are	be	AUX
bibechana-29750	106	22	tabulated	tabulate	VERB
bibechana-29750	106	23	in	in	ADP
bibechana-29750	106	24	table	table	NOUN
bibechana-29750	106	25	1	1	NUM
bibechana-29750	106	26	and	and	CCONJ
bibechana-29750	106	27	table	table	NOUN
bibechana-29750	106	28	2	2	NUM
bibechana-29750	106	29	for	for	ADP
bibechana-29750	106	30	all	all	DET
bibechana-29750	106	31	the	the	DET
bibechana-29750	106	32	six	six	NUM
bibechana-29750	106	33	systems	system	NOUN
bibechana-29750	106	34	.	.	PUNCT
bibechana-29750	107	1	the	the	DET
bibechana-29750	107	2	average	average	ADJ
bibechana-29750	107	3	specific	specific	ADJ
bibechana-29750	107	4	heat	heat	NOUN
bibechana-29750	107	5	capacity	capacity	NOUN
bibechana-29750	107	6	of	of	ADP
bibechana-29750	107	7	sickle	sickle	PROPN
bibechana-29750	107	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	107	9	67.1906	67.1906	NUM
bibechana-29750	107	10	3	3	NUM
bibechana-29750	107	11	122719662527	122719662527	NUM
bibechana-29750	107	12	(	(	PUNCT
bibechana-29750	107	13	=	=	PUNCT
bibechana-29750	107	14	+	+	PROPN
bibechana-29750	107	15	+	+	PROPN
bibechana-29750	107	16	j	j	PROPN
bibechana-29750	107	17	/	/	SYM
bibechana-29750	107	18	kg	kg	PROPN
bibechana-29750	107	19	-	-	PUNCT
bibechana-29750	107	20	c	c	NOUN
bibechana-29750	108	1	[	[	NOUN
bibechana-29750	108	2	table	table	NOUN
bibechana-29750	108	3	1	1	NUM
bibechana-29750	108	4	]	]	PUNCT
bibechana-29750	108	5	)	)	PUNCT
bibechana-29750	108	6	was	be	AUX
bibechana-29750	108	7	less	less	ADJ
bibechana-29750	108	8	than	than	ADP
bibechana-29750	108	9	of	of	ADP
bibechana-29750	108	10	normal	normal	ADJ
bibechana-29750	108	11	hemoglobin	hemoglobin	NOUN
bibechana-29750	108	12	's	's	PART
bibechana-29750	108	13	(	(	PUNCT
bibechana-29750	108	14	3587	3587	NUM
bibechana-29750	108	15	j	j	PROPN
bibechana-29750	108	16	/	/	SYM
bibechana-29750	108	17	kg	kg	PROPN
bibechana-29750	108	18	-	-	PUNCT
bibechana-29750	108	19	c	c	NOUN
bibechana-29750	108	20	,	,	PUNCT
bibechana-29750	108	21	2903	2903	NUM
bibechana-29750	108	22	j	j	PROPN
bibechana-29750	108	23	/	/	SYM
bibechana-29750	108	24	kg	kg	PROPN
bibechana-29750	108	25	-	-	PUNCT
bibechana-29750	108	26	c	c	PROPN
bibechana-29750	108	27	and	and	CCONJ
bibechana-29750	108	28	3204	3204	NUM
bibechana-29750	108	29	j	j	PROPN
bibechana-29750	108	30	/	/	SYM
bibechana-29750	108	31	kg	kg	PROPN
bibechana-29750	108	32	-	-	PUNCT
bibechana-29750	108	33	c	c	NOUN
bibechana-29750	108	34	)	)	PUNCT
bibechana-29750	109	1	[	[	X
bibechana-29750	109	2	table:2	table:2	X
bibechana-29750	109	3	]	]	PUNCT
bibechana-29750	109	4	.	.	PUNCT
bibechana-29750	110	1	fig	fig	NOUN
bibechana-29750	110	2	.	.	PUNCT
bibechana-29750	111	1	3	3	NUM
bibechana-29750	111	2	:	:	PUNCT
bibechana-29750	111	3	(	(	PUNCT
bibechana-29750	111	4	a	a	X
bibechana-29750	111	5	)	)	PUNCT
bibechana-29750	111	6	rmsd	rmsd	NOUN
bibechana-29750	111	7	graph	graph	NOUN
bibechana-29750	111	8	of	of	ADP
bibechana-29750	111	9	oxygenated	oxygenated	ADJ
bibechana-29750	111	10	sickle	sickle	NOUN
bibechana-29750	111	11	hemoglobin	hemoglobin	NOUN
bibechana-29750	111	12	protein	protein	NOUN
bibechana-29750	111	13	(	(	PUNCT
bibechana-29750	111	14	left	leave	VERB
bibechana-29750	111	15	)	)	PUNCT
bibechana-29750	111	16	.	.	PUNCT
bibechana-29750	112	1	(	(	PUNCT
bibechana-29750	112	2	b	b	X
bibechana-29750	112	3	)	)	PUNCT
bibechana-29750	112	4	rmsd	rmsd	NOUN
bibechana-29750	112	5	graph	graph	NOUN
bibechana-29750	112	6	of	of	ADP
bibechana-29750	112	7	deoxygenated	deoxygenate	VERB
bibechana-29750	112	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	112	9	protein	protein	NOUN
bibechana-29750	112	10	(	(	PUNCT
bibechana-29750	112	11	right	right	ADJ
bibechana-29750	112	12	)	)	PUNCT
bibechana-29750	112	13	.	.	PUNCT
bibechana-29750	113	1	jhulan	jhulan	PROPN
bibechana-29750	113	2	powrel	powrel	PROPN
bibechana-29750	113	3	,	,	PUNCT
bibechana-29750	113	4	narayan	narayan	PROPN
bibechana-29750	114	1	p.	p.	NOUN
bibechana-29750	114	2	adhikari/	adhikari/	NUM
bibechana-29750	114	3	bibechana	bibechana	NOUN
bibechana-29750	114	4	18	18	NUM
bibechana-29750	114	5	(	(	PUNCT
bibechana-29750	114	6	1)(2021	1)(2021	NUM
bibechana-29750	114	7	)	)	PUNCT
bibechana-29750	114	8	140	140	NUM
bibechana-29750	114	9	-	-	SYM
bibechana-29750	114	10	148	148	NUM
bibechana-29750	114	11	146	146	NUM
bibechana-29750	114	12	fig	fig	NOUN
bibechana-29750	114	13	.	.	PUNCT
bibechana-29750	115	1	4	4	NUM
bibechana-29750	115	2	:	:	PUNCT
bibechana-29750	115	3	(	(	PUNCT
bibechana-29750	115	4	a	a	X
bibechana-29750	115	5	)	)	PUNCT
bibechana-29750	115	6	rmsd	rmsd	NOUN
bibechana-29750	115	7	graph	graph	NOUN
bibechana-29750	115	8	of	of	ADP
bibechana-29750	115	9	oxygenated	oxygenated	ADJ
bibechana-29750	115	10	hemoglobin	hemoglobin	NOUN
bibechana-29750	115	11	protein	protein	NOUN
bibechana-29750	115	12	(	(	PUNCT
bibechana-29750	115	13	left	leave	VERB
bibechana-29750	115	14	)	)	PUNCT
bibechana-29750	115	15	.	.	PUNCT
bibechana-29750	116	1	(	(	PUNCT
bibechana-29750	116	2	b	b	X
bibechana-29750	116	3	)	)	PUNCT
bibechana-29750	116	4	rmsd	rmsd	NOUN
bibechana-29750	116	5	graph	graph	NOUN
bibechana-29750	116	6	of	of	ADP
bibechana-29750	116	7	sickle	sickle	NOUN
bibechana-29750	116	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	116	9	protein	protein	NOUN
bibechana-29750	116	10	(	(	PUNCT
bibechana-29750	116	11	right	right	ADJ
bibechana-29750	116	12	)	)	PUNCT
bibechana-29750	116	13	.	.	PUNCT
bibechana-29750	117	1	fig	fig	NOUN
bibechana-29750	117	2	.	.	PUNCT
bibechana-29750	118	1	5	5	NUM
bibechana-29750	118	2	:	:	PUNCT
bibechana-29750	118	3	(	(	PUNCT
bibechana-29750	118	4	a	a	X
bibechana-29750	118	5	)	)	PUNCT
bibechana-29750	118	6	rmsd	rmsd	NOUN
bibechana-29750	118	7	graph	graph	NOUN
bibechana-29750	118	8	of	of	ADP
bibechana-29750	118	9	sickle	sickle	NOUN
bibechana-29750	118	10	hemoglobin	hemoglobin	NOUN
bibechana-29750	118	11	protein	protein	NOUN
bibechana-29750	118	12	at	at	ADP
bibechana-29750	118	13	305	305	NUM
bibechana-29750	118	14	k	k	NOUN
bibechana-29750	118	15	(	(	PUNCT
bibechana-29750	118	16	left	leave	VERB
bibechana-29750	118	17	)	)	PUNCT
bibechana-29750	118	18	.	.	PUNCT
bibechana-29750	119	1	(	(	PUNCT
bibechana-29750	119	2	b	b	X
bibechana-29750	119	3	)	)	PUNCT
bibechana-29750	119	4	rmsd	rmsd	NOUN
bibechana-29750	119	5	graph	graph	NOUN
bibechana-29750	119	6	of	of	ADP
bibechana-29750	119	7	sickle	sickle	NOUN
bibechana-29750	119	8	hemoglobin	hemoglobin	NOUN
bibechana-29750	119	9	protein	protein	NOUN
bibechana-29750	119	10	at	at	ADP
bibechana-29750	119	11	315	315	NUM
bibechana-29750	119	12	k	k	NOUN
bibechana-29750	119	13	(	(	PUNCT
bibechana-29750	119	14	right	right	NOUN
bibechana-29750	119	15	)	)	PUNCT
bibechana-29750	119	16	.	.	PUNCT
bibechana-29750	120	1	fig	fig	NOUN
bibechana-29750	120	2	.	.	PUNCT
bibechana-29750	121	1	6	6	NUM
bibechana-29750	121	2	:	:	PUNCT
bibechana-29750	121	3	(	(	PUNCT
bibechana-29750	121	4	a	a	X
bibechana-29750	121	5	)	)	PUNCT
bibechana-29750	121	6	energy	energy	NOUN
bibechana-29750	121	7	flocculation	flocculation	NOUN
bibechana-29750	121	8	of	of	ADP
bibechana-29750	121	9	de	de	ADJ
bibechana-29750	121	10	-	-	ADJ
bibechana-29750	121	11	oxygenated	oxygenated	ADJ
bibechana-29750	121	12	hemoglobin	hemoglobin	NOUN
bibechana-29750	121	13	protein	protein	NOUN
bibechana-29750	121	14	(	(	PUNCT
bibechana-29750	121	15	b	b	NOUN
bibechana-29750	121	16	)	)	PUNCT
bibechana-29750	121	17	maxwell	maxwell	PROPN
bibechana-29750	121	18	energy	energy	NOUN
bibechana-29750	121	19	distribution	distribution	NOUN
bibechana-29750	121	20	for	for	ADP
bibechana-29750	121	21	de	de	ADJ
bibechana-29750	121	22	-	-	ADJ
bibechana-29750	121	23	oxygenated	oxygenated	ADJ
bibechana-29750	121	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	121	25	protein	protein	NOUN
bibechana-29750	121	26	.	.	PUNCT
bibechana-29750	122	1	jhulan	jhulan	PROPN
bibechana-29750	122	2	powrel	powrel	PROPN
bibechana-29750	122	3	,	,	PUNCT
bibechana-29750	122	4	narayan	narayan	PROPN
bibechana-29750	123	1	p.	p.	NOUN
bibechana-29750	123	2	adhikari/	adhikari/	NUM
bibechana-29750	123	3	bibechana	bibechana	NOUN
bibechana-29750	123	4	18	18	NUM
bibechana-29750	123	5	(	(	PUNCT
bibechana-29750	123	6	1)(2021	1)(2021	NUM
bibechana-29750	123	7	)	)	PUNCT
bibechana-29750	123	8	140	140	NUM
bibechana-29750	123	9	-	-	SYM
bibechana-29750	123	10	148	148	NUM
bibechana-29750	123	11	147	147	NUM
bibechana-29750	123	12	table	table	NOUN
bibechana-29750	123	13	1	1	NUM
bibechana-29750	123	14	:	:	PUNCT
bibechana-29750	123	15	for	for	ADP
bibechana-29750	123	16	normal	normal	ADJ
bibechana-29750	123	17	and	and	CCONJ
bibechana-29750	123	18	sickle	sickle	NOUN
bibechana-29750	123	19	cell	cell	NOUN
bibechana-29750	123	20	hemoglobin	hemoglobin	NOUN
bibechana-29750	123	21	protein	protein	NOUN
bibechana-29750	123	22	at	at	ADP
bibechana-29750	123	23	310	310	NUM
bibechana-29750	123	24	k	k	NOUN
bibechana-29750	123	25	of	of	ADP
bibechana-29750	123	26	temperature	temperature	NOUN
bibechana-29750	123	27	.	.	PUNCT
bibechana-29750	124	1	for	for	ADP
bibechana-29750	124	2	rmsd(å	rmsd(å	PROPN
bibechana-29750	124	3	)	)	PUNCT
bibechana-29750	124	4	cv(jkg−1c−1	cv(jkg−1c−1	NOUN
bibechana-29750	124	5	)	)	PUNCT
bibechana-29750	124	6	oxygenated	oxygenate	VERB
bibechana-29750	124	7	sickle	sickle	PROPN
bibechana-29750	124	8	hemoglobin	hemoglobin	PROPN
bibechana-29750	124	9	protein	protein	NOUN
bibechana-29750	124	10	)	)	PUNCT
bibechana-29750	124	11	0.8	0.8	NUM
bibechana-29750	124	12	3587	3587	NUM
bibechana-29750	124	13	de	de	ADJ
bibechana-29750	124	14	-	-	ADJ
bibechana-29750	124	15	oxygenated	oxygenated	ADJ
bibechana-29750	124	16	hemoglobin	hemoglobin	NOUN
bibechana-29750	124	17	protein	protein	NOUN
bibechana-29750	124	18	1.25	1.25	NUM
bibechana-29750	124	19	2903	2903	NUM
bibechana-29750	124	20	oxygenated	oxygenate	VERB
bibechana-29750	124	21	hemoglobin	hemoglobin	NOUN
bibechana-29750	124	22	protein	protein	NOUN
bibechana-29750	124	23	1.3	1.3	NUM
bibechana-29750	124	24	3204	3204	NUM
bibechana-29750	124	25	sickle	sickle	NOUN
bibechana-29750	124	26	hemoglobin	hemoglobin	PROPN
bibechana-29750	124	27	protein(2hbs	protein(2hbs	PROPN
bibechana-29750	124	28	)	)	PUNCT
bibechana-29750	124	29	0.75	0.75	NUM
bibechana-29750	124	30	1966	1966	NUM
bibechana-29750	124	31	table	table	NOUN
bibechana-29750	124	32	2	2	NUM
bibechana-29750	124	33	:	:	PUNCT
bibechana-29750	124	34	for	for	ADP
bibechana-29750	124	35	sickle	sickle	NOUN
bibechana-29750	124	36	cell	cell	NOUN
bibechana-29750	124	37	hemoglobin	hemoglobin	NOUN
bibechana-29750	124	38	protein	protein	NOUN
bibechana-29750	124	39	(	(	PUNCT
bibechana-29750	124	40	2hbs	2hbs	NUM
bibechana-29750	124	41	)	)	PUNCT
bibechana-29750	124	42	at	at	ADP
bibechana-29750	124	43	different	different	ADJ
bibechana-29750	124	44	temperature	temperature	NOUN
bibechana-29750	124	45	.	.	PUNCT
bibechana-29750	125	1	for	for	ADP
bibechana-29750	125	2	temp.(k	temp.(k	NOUN
bibechana-29750	125	3	)	)	PUNCT
bibechana-29750	125	4	rmsd(å	rmsd(å	PROPN
bibechana-29750	125	5	)	)	PUNCT
bibechana-29750	125	6	cv(jkg−1c−1	cv(jkg−1c−1	NOUN
bibechana-29750	125	7	)	)	PUNCT
bibechana-29750	125	8	sickle	sickle	NOUN
bibechana-29750	125	9	hemoglobin	hemoglobin	PROPN
bibechana-29750	125	10	protein(2hbs	protein(2hbs	PROPN
bibechana-29750	125	11	)	)	PUNCT
bibechana-29750	125	12	305	305	NUM
bibechana-29750	125	13	1.5	1.5	NUM
bibechana-29750	125	14	2527	2527	NUM
bibechana-29750	125	15	sickle	sickle	PROPN
bibechana-29750	125	16	hemoglobin	hemoglobin	PROPN
bibechana-29750	125	17	protein(2hbs	protein(2hbs	PROPN
bibechana-29750	125	18	)	)	PUNCT
bibechana-29750	125	19	310	310	NUM
bibechana-29750	125	20	0.75	0.75	NUM
bibechana-29750	125	21	1966	1966	NUM
bibechana-29750	125	22	sickle	sickle	NOUN
bibechana-29750	125	23	hemoglobin	hemoglobin	PROPN
bibechana-29750	125	24	protein(2hbs	protein(2hbs	PROPN
bibechana-29750	125	25	)	)	PUNCT
bibechana-29750	125	26	315	315	NUM
bibechana-29750	125	27	1.4	1.4	NUM
bibechana-29750	125	28	1227	1227	NUM
bibechana-29750	125	29	5	5	NUM
bibechana-29750	125	30	.	.	PUNCT
bibechana-29750	126	1	conclusion	conclusion	NOUN
bibechana-29750	126	2	and	and	CCONJ
bibechana-29750	126	3	concluding	concluding	NOUN
bibechana-29750	126	4	remarks	remark	VERB
bibechana-29750	126	5	the	the	DET
bibechana-29750	126	6	rmsd	rmsd	NOUN
bibechana-29750	126	7	of	of	ADP
bibechana-29750	126	8	normal	normal	ADJ
bibechana-29750	126	9	and	and	CCONJ
bibechana-29750	126	10	sickle	sickle	NOUN
bibechana-29750	126	11	hemoglobin	hemoglobin	NOUN
bibechana-29750	126	12	protein	protein	NOUN
bibechana-29750	126	13	was	be	AUX
bibechana-29750	126	14	calculated	calculate	VERB
bibechana-29750	126	15	within	within	ADP
bibechana-29750	126	16	0.75	0.75	NUM
bibechana-29750	126	17	å	å	NOUN
bibechana-29750	126	18	to	to	ADP
bibechana-29750	126	19	1.5	1.5	NUM
bibechana-29750	126	20	å	å	NOUN
bibechana-29750	126	21	which	which	PRON
bibechana-29750	126	22	indicates	indicate	VERB
bibechana-29750	126	23	that	that	SCONJ
bibechana-29750	126	24	the	the	DET
bibechana-29750	126	25	proposed	propose	VERB
bibechana-29750	126	26	system	system	NOUN
bibechana-29750	126	27	is	be	AUX
bibechana-29750	126	28	in	in	ADP
bibechana-29750	126	29	the	the	DET
bibechana-29750	126	30	valid	valid	ADJ
bibechana-29750	126	31	range	range	NOUN
bibechana-29750	126	32	(	(	PUNCT
bibechana-29750	126	33	<	<	X
bibechana-29750	126	34	4	4	NUM
bibechana-29750	126	35	å	å	NOUN
bibechana-29750	126	36	)	)	PUNCT
bibechana-29750	126	37	for	for	ADP
bibechana-29750	126	38	molecular	molecular	ADJ
bibechana-29750	126	39	dynamical	dynamical	ADJ
bibechana-29750	126	40	study	study	NOUN
bibechana-29750	126	41	.	.	PUNCT
bibechana-29750	127	1	this	this	DET
bibechana-29750	127	2	study	study	NOUN
bibechana-29750	127	3	also	also	ADV
bibechana-29750	127	4	reveals	reveal	VERB
bibechana-29750	127	5	that	that	SCONJ
bibechana-29750	127	6	the	the	DET
bibechana-29750	127	7	hbs	hbs	PROPN
bibechana-29750	127	8	at	at	ADP
bibechana-29750	127	9	305	305	NUM
bibechana-29750	127	10	k	k	X
bibechana-29750	127	11	is	be	AUX
bibechana-29750	127	12	most	most	ADV
bibechana-29750	127	13	unstable	unstable	ADJ
bibechana-29750	127	14	(	(	PUNCT
bibechana-29750	127	15	rmsd=1.5	rmsd=1.5	NOUN
bibechana-29750	127	16	å	å	PROPN
bibechana-29750	127	17	)	)	PUNCT
bibechana-29750	127	18	among	among	ADP
bibechana-29750	127	19	the	the	DET
bibechana-29750	127	20	considered	consider	VERB
bibechana-29750	127	21	system	system	NOUN
bibechana-29750	127	22	.	.	PUNCT
bibechana-29750	128	1	the	the	DET
bibechana-29750	128	2	rmsd	rmsd	NOUN
bibechana-29750	128	3	and	and	CCONJ
bibechana-29750	128	4	specific	specific	ADJ
bibechana-29750	128	5	heat	heat	NOUN
bibechana-29750	128	6	capacity	capacity	NOUN
bibechana-29750	128	7	(	(	PUNCT
bibechana-29750	128	8	cv	cv	NOUN
bibechana-29750	128	9	)	)	PUNCT
bibechana-29750	128	10	of	of	ADP
bibechana-29750	128	11	de	de	ADJ
bibechana-29750	128	12	-	-	ADJ
bibechana-29750	128	13	oxygenated	oxygenated	ADJ
bibechana-29750	128	14	hemoglobin	hemoglobin	NOUN
bibechana-29750	128	15	protein	protein	NOUN
bibechana-29750	128	16	at	at	ADP
bibechana-29750	128	17	310	310	NUM
bibechana-29750	128	18	k	k	NOUN
bibechana-29750	128	19	are	be	AUX
bibechana-29750	128	20	estimated	estimate	VERB
bibechana-29750	128	21	as	as	ADP
bibechana-29750	128	22	1.25	1.25	NUM
bibechana-29750	128	23	å	å	PROPN
bibechana-29750	128	24	and	and	CCONJ
bibechana-29750	128	25	2903	2903	NUM
bibechana-29750	128	26	j	j	PROPN
bibechana-29750	128	27	/	/	SYM
bibechana-29750	128	28	kg	kg	PROPN
bibechana-29750	128	29	-	-	PUNCT
bibechana-29750	128	30	c	c	NOUN
bibechana-29750	129	1	[	[	NOUN
bibechana-29750	129	2	table	table	NOUN
bibechana-29750	129	3	1	1	NUM
bibechana-29750	129	4	]	]	PUNCT
bibechana-29750	129	5	respectively	respectively	ADV
bibechana-29750	129	6	.	.	PUNCT
bibechana-29750	130	1	it	it	PRON
bibechana-29750	130	2	also	also	ADV
bibechana-29750	130	3	obvious	obvious	ADJ
bibechana-29750	130	4	that	that	SCONJ
bibechana-29750	130	5	the	the	DET
bibechana-29750	130	6	de	de	ADJ
bibechana-29750	130	7	-	-	ADJ
bibechana-29750	130	8	oxygenated	oxygenated	ADJ
bibechana-29750	130	9	hemoglobin	hemoglobin	NOUN
bibechana-29750	130	10	protein	protein	NOUN
bibechana-29750	130	11	(	(	PUNCT
bibechana-29750	130	12	average	average	ADJ
bibechana-29750	130	13	value=1906.67j	value=1906.67j	ADJ
bibechana-29750	130	14	/	/	SYM
bibechana-29750	130	15	kg	kg	NOUN
bibechana-29750	130	16	-	-	PUNCT
bibechana-29750	130	17	c	c	NOUN
bibechana-29750	130	18	)	)	PUNCT
bibechana-29750	130	19	has	have	VERB
bibechana-29750	130	20	lower	low	ADJ
bibechana-29750	130	21	specific	specific	ADJ
bibechana-29750	130	22	heat	heat	NOUN
bibechana-29750	130	23	capacity	capacity	NOUN
bibechana-29750	130	24	than	than	ADP
bibechana-29750	130	25	oxygenated	oxygenated	ADJ
bibechana-29750	130	26	(	(	PUNCT
bibechana-29750	130	27	first	first	ADV
bibechana-29750	130	28	three	three	NUM
bibechana-29750	130	29	cv	cv	NOUN
bibechana-29750	130	30	of	of	ADP
bibechana-29750	130	31	table	table	NOUN
bibechana-29750	130	32	1	1	NUM
bibechana-29750	130	33	)	)	PUNCT
bibechana-29750	130	34	.	.	PUNCT
bibechana-29750	131	1	it	it	PRON
bibechana-29750	131	2	shows	show	VERB
bibechana-29750	131	3	that	that	SCONJ
bibechana-29750	131	4	at	at	ADP
bibechana-29750	131	5	higher	high	ADJ
bibechana-29750	131	6	(	(	PUNCT
bibechana-29750	131	7	315	315	NUM
bibechana-29750	131	8	k	k	NOUN
bibechana-29750	131	9	)	)	PUNCT
bibechana-29750	131	10	temperature	temperature	NOUN
bibechana-29750	131	11	above	above	ADP
bibechana-29750	131	12	310	310	NUM
bibechana-29750	131	13	k	k	NOUN
bibechana-29750	131	14	the	the	DET
bibechana-29750	131	15	rmsd	rmsd	NOUN
bibechana-29750	131	16	of	of	ADP
bibechana-29750	131	17	sickle	sickle	NOUN
bibechana-29750	131	18	hemoglobin	hemoglobin	NOUN
bibechana-29750	131	19	protein	protein	NOUN
bibechana-29750	131	20	is	be	AUX
bibechana-29750	131	21	increased	increase	VERB
bibechana-29750	131	22	due	due	ADP
bibechana-29750	131	23	to	to	ADP
bibechana-29750	131	24	less	less	ADJ
bibechana-29750	131	25	polymerization	polymerization	NOUN
bibechana-29750	131	26	(	(	PUNCT
bibechana-29750	131	27	sickling	sickling	NOUN
bibechana-29750	131	28	)	)	PUNCT
bibechana-29750	131	29	of	of	ADP
bibechana-29750	131	30	protein	protein	NOUN
bibechana-29750	131	31	but	but	CCONJ
bibechana-29750	131	32	increased	increase	VERB
bibechana-29750	131	33	in	in	ADP
bibechana-29750	131	34	rmsd	rmsd	NOUN
bibechana-29750	131	35	at	at	ADP
bibechana-29750	131	36	lower	low	ADJ
bibechana-29750	131	37	temperature	temperature	NOUN
bibechana-29750	131	38	(	(	PUNCT
bibechana-29750	131	39	305	305	NUM
bibechana-29750	131	40	k	k	NOUN
bibechana-29750	131	41	)	)	PUNCT
bibechana-29750	131	42	is	be	AUX
bibechana-29750	131	43	still	still	ADV
bibechana-29750	131	44	not	not	PART
bibechana-29750	131	45	understood	understand	VERB
bibechana-29750	131	46	.	.	PUNCT
bibechana-29750	132	1	we	we	PRON
bibechana-29750	132	2	found	find	VERB
bibechana-29750	132	3	essentiality	essentiality	NOUN
bibechana-29750	132	4	of	of	ADP
bibechana-29750	132	5	additional	additional	ADJ
bibechana-29750	132	6	research	research	NOUN
bibechana-29750	132	7	work	work	NOUN
bibechana-29750	132	8	on	on	ADP
bibechana-29750	132	9	the	the	DET
bibechana-29750	132	10	free	free	ADJ
bibechana-29750	132	11	energy	energy	NOUN
bibechana-29750	132	12	calculation	calculation	NOUN
bibechana-29750	132	13	along	along	ADP
bibechana-29750	132	14	with	with	ADP
bibechana-29750	132	15	the	the	DET
bibechana-29750	132	16	mechanical	mechanical	ADJ
bibechana-29750	132	17	and	and	CCONJ
bibechana-29750	132	18	transport	transport	NOUN
bibechana-29750	132	19	properties	property	NOUN
bibechana-29750	132	20	of	of	ADP
bibechana-29750	132	21	sickle	sickle	NOUN
bibechana-29750	132	22	hemoglobin	hemoglobin	NOUN
bibechana-29750	132	23	protein	protein	NOUN
bibechana-29750	132	24	for	for	ADP
bibechana-29750	132	25	its	its	PRON
bibechana-29750	132	26	depth	depth	NOUN
bibechana-29750	132	27	knowledge	knowledge	NOUN
bibechana-29750	132	28	.	.	PUNCT
bibechana-29750	133	1	acknowledgments	acknowledgment	NOUN
bibechana-29750	133	2	jp	jp	PROPN
bibechana-29750	133	3	acknowledges	acknowledge	VERB
bibechana-29750	133	4	ugc	ugc	PROPN
bibechana-29750	133	5	,	,	PUNCT
bibechana-29750	133	6	nepal	nepal	NOUN
bibechana-29750	133	7	for	for	ADP
bibechana-29750	133	8	providing	provide	VERB
bibechana-29750	133	9	financial	financial	ADJ
bibechana-29750	133	10	support	support	NOUN
bibechana-29750	133	11	(	(	PUNCT
bibechana-29750	133	12	grant	grant	VERB
bibechana-29750	133	13	no	no	INTJ
bibechana-29750	133	14	.	.	PUNCT
bibechana-29750	134	1	s&t-13	s&t-13	NOUN
bibechana-29750	134	2	-	-	PUNCT
bibechana-29750	134	3	75/76	75/76	NUM
bibechana-29750	134	4	)	)	PUNCT
bibechana-29750	134	5	and	and	CCONJ
bibechana-29750	134	6	butwal	butwal	VERB
bibechana-29750	134	7	multiple	multiple	ADJ
bibechana-29750	134	8	campus	campus	NOUN
bibechana-29750	134	9	,	,	PUNCT
bibechana-29750	135	1	butwal	butwal	PROPN
bibechana-29750	135	2	(	(	PUNCT
bibechana-29750	135	3	tribhuvan	tribhuvan	PROPN
bibechana-29750	135	4	university	university	PROPN
bibechana-29750	135	5	)	)	PUNCT
bibechana-29750	135	6	for	for	ADP
bibechana-29750	135	7	providing	provide	VERB
bibechana-29750	135	8	ph	ph	PROPN
bibechana-29750	135	9	.	.	PROPN
bibechana-29750	135	10	d.	d.	PROPN
bibechana-29750	135	11	leave	leave	VERB
bibechana-29750	135	12	.	.	PUNCT
bibechana-29750	136	1	this	this	DET
bibechana-29750	136	2	work	work	NOUN
bibechana-29750	136	3	is	be	AUX
bibechana-29750	136	4	also	also	ADV
bibechana-29750	136	5	under	under	ADP
bibechana-29750	136	6	the	the	DET
bibechana-29750	136	7	grant	grant	NOUN
bibechana-29750	136	8	of	of	ADP
bibechana-29750	136	9	ugc	ugc	PROPN
bibechana-29750	136	10	,	,	PUNCT
bibechana-29750	136	11	nepal	nepal	NOUN
bibechana-29750	136	12	for	for	ADP
bibechana-29750	136	13	which	which	PRON
bibechana-29750	136	14	npa	npa	PROPN
bibechana-29750	136	15	acknowledges	acknowledge	VERB
bibechana-29750	136	16	the	the	DET
bibechana-29750	136	17	ugc	ugc	PROPN
bibechana-29750	136	18	award	award	PROPN
bibechana-29750	136	19	no	no	PROPN
bibechana-29750	136	20	.	.	PUNCT
bibechana-29750	137	1	crg-73/74	crg-73/74	PROPN
bibechana-29750	137	2	-	-	PUNCT
bibechana-29750	137	3	s&t-01	s&t-01	PROPN
bibechana-29750	137	4	.	.	PUNCT
bibechana-29750	138	1	references	reference	NOUN
bibechana-29750	138	2	[	[	X
bibechana-29750	138	3	1	1	NUM
bibechana-29750	138	4	]	]	PUNCT
bibechana-29750	138	5	a.	a.	NOUN
bibechana-29750	138	6	stradner	stradner	PROPN
bibechana-29750	138	7	et	et	PROPN
bibechana-29750	138	8	al	al	PROPN
bibechana-29750	138	9	,	,	PUNCT
bibechana-29750	138	10	new	new	ADJ
bibechana-29750	138	11	insight	insight	NOUN
bibechana-29750	138	12	into	into	ADP
bibechana-29750	138	13	cataract	cataract	NOUN
bibechana-29750	138	14	formation	formation	NOUN
bibechana-29750	138	15	â	â	VERB
bibechana-29750	138	16	enhanced	enhance	VERB
bibechana-29750	138	17	stability	stability	NOUN
bibechana-29750	138	18	through	through	ADP
bibechana-29750	138	19	mutual	mutual	ADJ
bibechana-29750	138	20	attraction	attraction	NOUN
bibechana-29750	138	21	,	,	PUNCT
bibechana-29750	138	22	physics	physics	NOUN
bibechana-29750	138	23	department	department	PROPN
bibechana-29750	138	24	and	and	CCONJ
bibechana-29750	138	25	fribourg	fribourg	NOUN
bibechana-29750	138	26	center	center	NOUN
bibechana-29750	138	27	for	for	ADP
bibechana-29750	138	28	nanomaterials	nanomaterial	NOUN
bibechana-29750	138	29	,	,	PUNCT
bibechana-29750	138	30	university	university	NOUN
bibechana-29750	138	31	of	of	ADP
bibechana-29750	138	32	fribourg	fribourg	PROPN
bibechana-29750	138	33	,	,	PUNCT
bibechana-29750	138	34	ch1700	ch1700	NOUN
bibechana-29750	138	35	fribourg	fribourg	PROPN
bibechana-29750	138	36	,	,	PUNCT
bibechana-29750	138	37	switzerland	switzerland	PROPN
bibechana-29750	138	38	(	(	PUNCT
bibechana-29750	138	39	2007	2007	NUM
bibechana-29750	138	40	)	)	PUNCT
bibechana-29750	138	41	.	.	PUNCT
bibechana-29750	139	1	jhulan	jhulan	PROPN
bibechana-29750	139	2	powrel	powrel	PROPN
bibechana-29750	139	3	,	,	PUNCT
bibechana-29750	139	4	narayan	narayan	PROPN
bibechana-29750	140	1	p.	p.	NOUN
bibechana-29750	140	2	adhikari/	adhikari/	NUM
bibechana-29750	140	3	bibechana	bibechana	NOUN
bibechana-29750	140	4	18	18	NUM
bibechana-29750	140	5	(	(	PUNCT
bibechana-29750	140	6	1)(2021	1)(2021	NUM
bibechana-29750	140	7	)	)	PUNCT
bibechana-29750	140	8	140	140	NUM
bibechana-29750	140	9	-	-	SYM
bibechana-29750	140	10	148	148	NUM
bibechana-29750	140	11	148	148	NUM
bibechana-29750	140	12	[	[	X
bibechana-29750	140	13	2	2	NUM
bibechana-29750	140	14	]	]	PUNCT
bibechana-29750	140	15	w.	w.	PROPN
bibechana-29750	140	16	a.	a.	PROPN
bibechana-29750	140	17	eaton	eaton	PROPN
bibechana-29750	140	18	and	and	CCONJ
bibechana-29750	140	19	j.	j.	PROPN
bibechana-29750	140	20	hofrichter	hofrichter	PROPN
bibechana-29750	140	21	,	,	PUNCT
bibechana-29750	140	22	sickle	sickle	NOUN
bibechana-29750	140	23	cell	cell	NOUN
bibechana-29750	140	24	hemoglobin	hemoglobin	NOUN
bibechana-29750	140	25	polymerization	polymerization	NOUN
bibechana-29750	140	26	,	,	PUNCT
bibechana-29750	140	27	advances	advance	NOUN
bibechana-29750	140	28	in	in	ADP
bibechana-29750	140	29	protein	protein	NOUN
bibechana-29750	140	30	chemistry	chemistry	NOUN
bibechana-29750	140	31	40	40	NUM
bibechana-29750	140	32	(	(	PUNCT
bibechana-29750	140	33	1990	1990	NUM
bibechana-29750	140	34	)	)	PUNCT
bibechana-29750	140	35	63	63	NUM
bibechana-29750	140	36	-	-	SYM
bibechana-29750	140	37	279	279	NUM
bibechana-29750	140	38	.	.	PUNCT
bibechana-29750	141	1	http://doi.org/10.1016/s0065-3233(08)60287-9	http://doi.org/10.1016/s0065-3233(08)60287-9	PROPN
bibechana-29750	141	2	.	.	PUNCT
bibechana-29750	142	1	[	[	X
bibechana-29750	142	2	3	3	X
bibechana-29750	142	3	]	]	X
bibechana-29750	142	4	f.	f.	PROPN
bibechana-29750	142	5	ferrone	ferrone	PROPN
bibechana-29750	142	6	,	,	PUNCT
bibechana-29750	142	7	r.	r.	PROPN
bibechana-29750	142	8	l.	l.	PROPN
bibechana-29750	142	9	nagel	nagel	PROPN
bibechana-29750	142	10	,	,	PUNCT
bibechana-29750	142	11	sickle	sickle	PROPN
bibechana-29750	142	12	hemoglobin	hemoglobin	PROPN
bibechana-29750	142	13	polymerization	polymerization	NOUN
bibechana-29750	142	14	.	.	PUNCT
bibechana-29750	143	1	in	in	ADP
bibechana-29750	143	2	:	:	PUNCT
bibechana-29750	143	3	disorders	disorder	NOUN
bibechana-29750	143	4	of	of	ADP
bibechana-29750	143	5	hemoglobin	hemoglobin	NOUN
bibechana-29750	143	6	:	:	PUNCT
bibechana-29750	143	7	genetics	genetic	NOUN
bibechana-29750	143	8	,	,	PUNCT
bibechana-29750	143	9	pathophysiology	pathophysiology	NOUN
bibechana-29750	143	10	,	,	PUNCT
bibechana-29750	143	11	clinical	clinical	ADJ
bibechana-29750	143	12	management	management	NOUN
bibechana-29750	143	13	,	,	PUNCT
bibechana-29750	143	14	steinberg	steinberg	PROPN
bibechana-29750	143	15	mh	mh	PROPN
bibechana-29750	143	16	,	,	PUNCT
bibechana-29750	143	17	for	for	SCONJ
bibechana-29750	143	18	get	get	VERB
bibechana-29750	143	19	bg	bg	PROPN
bibechana-29750	143	20	,	,	PUNCT
bibechana-29750	143	21	higgs	higgs	PROPN
bibechana-29750	143	22	d	d	PROPN
bibechana-29750	143	23	,	,	PUNCT
bibechana-29750	143	24	nagel	nagel	PROPN
bibechana-29750	143	25	rl	rl	PROPN
bibechana-29750	143	26	(	(	PUNCT
bibechana-29750	143	27	eds	ed	NOUN
bibechana-29750	143	28	)	)	PUNCT
bibechana-29750	143	29	,	,	PUNCT
bibechana-29750	143	30	cambridge	cambridge	PROPN
bibechana-29750	143	31	university	university	PROPN
bibechana-29750	143	32	press	press	NOUN
bibechana-29750	143	33	(	(	PUNCT
bibechana-29750	143	34	2000	2000	NUM
bibechana-29750	143	35	)	)	PUNCT
bibechana-29750	143	36	.	.	PUNCT
bibechana-29750	144	1	[	[	X
bibechana-29750	144	2	4	4	NUM
bibechana-29750	144	3	]	]	X
bibechana-29750	144	4	luzzatto	luzzatto	PROPN
bibechana-29750	144	5	,	,	PUNCT
bibechana-29750	144	6	lucio	lucio	PROPN
bibechana-29750	144	7	.	.	PROPN
bibechana-29750	144	8	,	,	PUNCT
bibechana-29750	144	9	sickle	sickle	NOUN
bibechana-29750	144	10	cell	cell	NOUN
bibechana-29750	144	11	anaemia	anaemia	NOUN
bibechana-29750	144	12	and	and	CCONJ
bibechana-29750	144	13	malaria	malaria	NOUN
bibechana-29750	144	14	,	,	PUNCT
bibechana-29750	144	15	mediterranean	mediterranean	PROPN
bibechana-29750	144	16	journal	journal	PROPN
bibechana-29750	144	17	of	of	ADP
bibechana-29750	144	18	hematology	hematology	NOUN
bibechana-29750	144	19	and	and	CCONJ
bibechana-29750	144	20	infectious	infectious	ADJ
bibechana-29750	144	21	diseases	disease	NOUN
bibechana-29750	144	22	(	(	PUNCT
bibechana-29750	144	23	4)1	4)1	NOUN
bibechana-29750	144	24	(	(	PUNCT
bibechana-29750	144	25	2012	2012	NUM
bibechana-29750	144	26	)	)	PUNCT
bibechana-29750	144	27	e2012065	e2012065	NOUN
bibechana-29750	144	28	.	.	PUNCT
bibechana-29750	145	1	http://doi.org/10.4084/mjhid.2012.065	http://doi.org/10.4084/mjhid.2012.065	NOUN
bibechana-29750	145	2	.	.	PUNCT
bibechana-29750	146	1	[	[	X
bibechana-29750	146	2	5	5	X
bibechana-29750	146	3	]	]	X
bibechana-29750	146	4	d.	d.	PROPN
bibechana-29750	146	5	c.	c.	PROPN
bibechana-29750	146	6	rees	rees	PROPN
bibechana-29750	146	7	,	,	PUNCT
bibechana-29750	146	8	t.	t.	PROPN
bibechana-29750	146	9	n.	n.	PROPN
bibechana-29750	146	10	williams	williams	PROPN
bibechana-29750	146	11	,	,	PUNCT
bibechana-29750	146	12	m.	m.	PROPN
bibechana-29750	146	13	t.	t.	PROPN
bibechana-29750	146	14	gladwin	gladwin	PROPN
bibechana-29750	146	15	,	,	PUNCT
bibechana-29750	146	16	sickle	sickle	NOUN
bibechana-29750	146	17	-	-	PUNCT
bibechana-29750	146	18	cell	cell	NOUN
bibechana-29750	146	19	disease	disease	NOUN
bibechana-29750	146	20	,	,	PUNCT
bibechana-29750	146	21	the	the	DET
bibechana-29750	146	22	lancet	lancet	PROPN
bibechana-29750	146	23	376(9757	376(9757	NUM
bibechana-29750	146	24	)	)	PUNCT
bibechana-29750	146	25	(	(	PUNCT
bibechana-29750	146	26	2010	2010	NUM
bibechana-29750	146	27	)	)	PUNCT
bibechana-29750	146	28	2018	2018	NUM
bibechana-29750	146	29	-	-	SYM
bibechana-29750	146	30	2031	2031	NUM
bibechana-29750	146	31	.	.	PUNCT
bibechana-29750	147	1	[	[	X
bibechana-29750	147	2	6	6	NUM
bibechana-29750	147	3	]	]	PUNCT
bibechana-29750	147	4	j.	j.	PROPN
bibechana-29750	147	5	robert	robert	PROPN
bibechana-29750	147	6	,	,	PUNCT
bibechana-29750	147	7	j.	j.	PROPN
bibechana-29750	147	8	ouellette	ouellette	PROPN
bibechana-29750	147	9	,	,	PUNCT
bibechana-29750	147	10	david	david	PROPN
bibechana-29750	147	11	rawn	rawn	PROPN
bibechana-29750	147	12	,	,	PUNCT
bibechana-29750	147	13	organic	organic	ADJ
bibechana-29750	147	14	chemistry	chemistry	NOUN
bibechana-29750	147	15	(	(	PUNCT
bibechana-29750	147	16	second	second	ADJ
bibechana-29750	147	17	edition	edition	NOUN
bibechana-29750	147	18	)	)	PUNCT
bibechana-29750	147	19	structure	structure	NOUN
bibechana-29750	147	20	,	,	PUNCT
bibechana-29750	147	21	mechanism	mechanism	NOUN
bibechana-29750	147	22	,	,	PUNCT
bibechana-29750	147	23	synthesis	synthesis	NOUN
bibechana-29750	147	24	(	(	PUNCT
bibechana-29750	147	25	2018	2018	NUM
bibechana-29750	147	26	)	)	PUNCT
bibechana-29750	147	27	pp	pp	ADP
bibechana-29750	147	28	.	.	PUNCT
bibechana-29750	148	1	929	929	NUM
bibechana-29750	148	2	-	-	SYM
bibechana-29750	148	3	971	971	NUM
bibechana-29750	148	4	.	.	PUNCT
bibechana-29750	149	1	[	[	X
bibechana-29750	149	2	7	7	X
bibechana-29750	149	3	]	]	X
bibechana-29750	149	4	w.	w.	PROPN
bibechana-29750	149	5	d.	d.	PROPN
bibechana-29750	149	6	callister	callister	PROPN
bibechana-29750	149	7	,	,	PUNCT
bibechana-29750	149	8	materials	material	NOUN
bibechana-29750	149	9	science	science	NOUN
bibechana-29750	149	10	and	and	CCONJ
bibechana-29750	149	11	engeenering	engeenering	NOUN
bibechana-29750	149	12	,	,	PUNCT
bibechana-29750	149	13	an	an	DET
bibechana-29750	149	14	introduction	introduction	NOUN
bibechana-29750	149	15	,	,	PUNCT
bibechana-29750	149	16	john	john	PROPN
bibechana-29750	149	17	wiley	wiley	PROPN
bibechana-29750	149	18	sons.inc	sons.inc	PROPN
bibechana-29750	149	19	.	.	PUNCT
bibechana-29750	150	1	us	we	PRON
bibechana-29750	150	2	,	,	PUNCT
bibechana-29750	150	3	(	(	PUNCT
bibechana-29750	150	4	2007	2007	NUM
bibechana-29750	150	5	)	)	PUNCT
bibechana-29750	150	6	.	.	PUNCT
bibechana-29750	151	1	[	[	X
bibechana-29750	151	2	8	8	NUM
bibechana-29750	151	3	]	]	PUNCT
bibechana-29750	151	4	retrieved	retrieve	VERB
bibechana-29750	151	5	sept	sept	PROPN
bibechana-29750	151	6	.	.	PROPN
bibechana-29750	151	7	22th	22th	NOUN
bibechana-29750	151	8	,	,	PUNCT
bibechana-29750	151	9	2018	2018	NUM
bibechana-29750	151	10	from	from	ADP
bibechana-29750	151	11	www.google.com/sickle	www.google.com/sickle	PROPN
bibechana-29750	151	12	cell	cell	NOUN
bibechana-29750	151	13	anemia	anemia	NOUN
bibechana-29750	151	14	.	.	PUNCT
bibechana-29750	152	1	[	[	X
bibechana-29750	152	2	9	9	NUM
bibechana-29750	152	3	]	]	PUNCT
bibechana-29750	152	4	mahran	mahran	NOUN
bibechana-29750	152	5	et	et	PROPN
bibechana-29750	152	6	al	al	PROPN
bibechana-29750	152	7	.	.	PROPN
bibechana-29750	152	8	,	,	PUNCT
bibechana-29750	152	9	beni	beni	ADJ
bibechana-29750	152	10	-	-	ADJ
bibechana-29750	152	11	suef	suef	ADJ
bibechana-29750	152	12	university	university	NOUN
bibechana-29750	152	13	journal	journal	NOUN
bibechana-29750	152	14	of	of	ADP
bibechana-29750	152	15	basic	basic	ADJ
bibechana-29750	152	16	and	and	CCONJ
bibechana-29750	152	17	applied	applied	ADJ
bibechana-29750	152	18	sciences	science	NOUN
bibechana-29750	152	19	,	,	PUNCT
bibechana-29750	152	20	springer	springer	NOUN
bibechana-29750	152	21	open	open	NOUN
bibechana-29750	152	22	,	,	PUNCT
bibechana-29750	152	23	egypt	egypt	PROPN
bibechana-29750	152	24	(	(	PUNCT
bibechana-29750	152	25	2019	2019	NUM
bibechana-29750	152	26	)	)	PUNCT
bibechana-29750	152	27	.	.	PUNCT
bibechana-29750	153	1	https	https	NOUN
bibechana-29750	153	2	:	:	PUNCT
bibechana-29750	154	1	//doi.org/10.1186	//doi.org/10.1186	ADP
bibechana-29750	154	2	/	/	SYM
bibechana-29750	154	3	s43088	s43088	NUM
bibechana-29750	154	4	−	−	NOUN
bibechana-29750	154	5	019	019	NUM
bibechana-29750	155	1	−	−	NOUN
bibechana-29750	155	2	0016	0016	NUM
bibechana-29750	156	1	−	−	NOUN
bibechana-29750	156	2	x	x	PUNCT
bibechana-29750	157	1	[	[	X
bibechana-29750	157	2	10	10	NUM
bibechana-29750	157	3	]	]	X
bibechana-29750	157	4	wang	wang	PROPN
bibechana-29750	157	5	xianqiao	xianqiao	PROPN
bibechana-29750	157	6	and	and	CCONJ
bibechana-29750	157	7	d.	d.	PROPN
bibechana-29750	157	8	rodne	rodne	PROPN
bibechana-29750	157	9	,	,	PUNCT
bibechana-29750	157	10	avereabtt	avereabtt	VERB
bibechana-29750	157	11	molecular	molecular	ADJ
bibechana-29750	157	12	dynamics	dynamic	NOUN
bibechana-29750	157	13	simulations	simulation	NOUN
bibechana-29750	157	14	indicate	indicate	VERB
bibechana-29750	157	15	that	that	DET
bibechana-29750	157	16	deoxyhemoglobin	deoxyhemoglobin	NOUN
bibechana-29750	157	17	,	,	PUNCT
bibechana-29750	157	18	oxyhemoglobin	oxyhemoglobin	PROPN
bibechana-29750	157	19	,	,	PUNCT
bibechana-29750	157	20	carboxy	carboxy	PROPN
bibechana-29750	157	21	-	-	PUNCT
bibechana-29750	157	22	hemoglobin	hemoglobin	NOUN
bibechana-29750	157	23	,	,	PUNCT
bibechana-29750	157	24	and	and	CCONJ
bibechana-29750	157	25	glycated	glycate	VERB
bibechana-29750	157	26	haemoglobin	haemoglobin	PROPN
bibechana-29750	157	27	hemoglobin	hemoglobin	NOUN
bibechana-29750	157	28	under	under	ADP
bibechana-29750	157	29	compression	compression	NOUN
bibechana-29750	157	30	and	and	CCONJ
bibechana-29750	157	31	shear	shear	NOUN
bibechana-29750	157	32	exhibit	exhibit	VERB
bibechana-29750	157	33	an	an	DET
bibechana-29750	157	34	anisotropic	anisotropic	NOUN
bibechana-29750	157	35	mechanical	mechanical	ADJ
bibechana-29750	157	36	behavior	behavior	NOUN
bibechana-29750	157	37	,	,	PUNCT
bibechana-29750	157	38	sumith	sumith	VERB
bibechana-29750	157	39	yesudasan	yesudasan	PROPN
bibechana-29750	157	40	orcid	orcid	PROPN
bibechana-29750	157	41	icon	icon	NOUN
bibechana-29750	157	42	(	(	PUNCT
bibechana-29750	157	43	2017)1417	2017)1417	NUM
bibechana-29750	157	44	-	-	PUNCT
bibechana-29750	157	45	1429	1429	NUM
bibechana-29750	157	46	.	.	PUNCT
bibechana-29750	158	1	https://doi.org/10.1080/07391102.2017.1323674	https://doi.org/10.1080/07391102.2017.1323674	NOUN
bibechana-29750	158	2	.	.	PUNCT
bibechana-29750	159	1	[	[	X
bibechana-29750	159	2	11	11	NUM
bibechana-29750	159	3	]	]	X
bibechana-29750	159	4	iqbal	iqbal	PROPN
bibechana-29750	159	5	,	,	PUNCT
bibechana-29750	159	6	zeshan	zeshan	PROPN
bibechana-29750	159	7	et	et	PROPN
bibechana-29750	159	8	al	al	PROPN
bibechana-29750	159	9	.	.	PROPN
bibechana-29750	159	10	,	,	PUNCT
bibechana-29750	159	11	investigation	investigation	NOUN
bibechana-29750	159	12	of	of	ADP
bibechana-29750	159	13	sickle	sickle	NOUN
bibechana-29750	159	14	-	-	PUNCT
bibechana-29750	159	15	cell	cell	NOUN
bibechana-29750	159	16	polymerisation	polymerisation	NOUN
bibechana-29750	159	17	under	under	ADP
bibechana-29750	159	18	electrochemical	electrochemical	ADJ
bibechana-29750	159	19	control	control	NOUN
bibechana-29750	159	20	,	,	PUNCT
bibechana-29750	159	21	chemphyschem	chemphyschem	NOUN
bibechana-29750	159	22	:	:	PUNCT
bibechana-29750	159	23	a	a	DET
bibechana-29750	159	24	european	european	ADJ
bibechana-29750	159	25	journal	journal	PROPN
bibechana-29750	159	26	of	of	ADP
bibechana-29750	159	27	chemical	chemical	PROPN
bibechana-29750	159	28	physics	physics	PROPN
bibechana-29750	159	29	and	and	CCONJ
bibechana-29750	159	30	physical	physical	ADJ
bibechana-29750	159	31	chemistry	chemistry	NOUN
bibechana-29750	159	32	14	14	NUM
bibechana-29750	159	33	(	(	PUNCT
bibechana-29750	159	34	10	10	NUM
bibechana-29750	159	35	)	)	PUNCT
bibechana-29750	159	36	(	(	PUNCT
bibechana-29750	159	37	2013	2013	NUM
bibechana-29750	159	38	)	)	PUNCT
bibechana-29750	159	39	2143	2143	NUM
bibechana-29750	159	40	-	-	SYM
bibechana-29750	159	41	8	8	NUM
bibechana-29750	159	42	.	.	PUNCT
bibechana-29750	159	43	https://doi.org/10.1002/cphc.201300203	https://doi.org/10.1002/cphc.201300203	X
bibechana-29750	159	44	.	.	PUNCT
bibechana-29750	160	1	[	[	X
bibechana-29750	160	2	12	12	NUM
bibechana-29750	160	3	]	]	X
bibechana-29750	160	4	g.	g.	PROPN
bibechana-29750	160	5	r.	r.	PROPN
bibechana-29750	160	6	serjeant	serjeant	PROPN
bibechana-29750	160	7	,	,	PUNCT
bibechana-29750	160	8	sickle	sickle	NOUN
bibechana-29750	160	9	-	-	PUNCT
bibechana-29750	160	10	cell	cell	NOUN
bibechana-29750	160	11	disease	disease	NOUN
bibechana-29750	160	12	.	.	PUNCT
bibechana-29750	161	1	the	the	DET
bibechana-29750	161	2	lancet	lancet	NOUN
bibechana-29750	161	3	350(9079	350(9079	NUM
bibechana-29750	161	4	)	)	PUNCT
bibechana-29750	161	5	(	(	PUNCT
bibechana-29750	161	6	1997	1997	NUM
bibechana-29750	161	7	)	)	PUNCT
bibechana-29750	161	8	725	725	NUM
bibechana-29750	161	9	-	-	SYM
bibechana-29750	161	10	730	730	NUM
bibechana-29750	162	1	[	[	SYM
bibechana-29750	162	2	13	13	NUM
bibechana-29750	162	3	]	]	PUNCT
bibechana-29750	162	4	m.	m.	NOUN
bibechana-29750	162	5	p.	p.	PROPN
bibechana-29750	162	6	allen	allen	PROPN
bibechana-29750	162	7	and	and	CCONJ
bibechana-29750	162	8	d.	d.	PROPN
bibechana-29750	162	9	j.	j.	PROPN
bibechana-29750	162	10	tildesley	tildesley	PROPN
bibechana-29750	162	11	.	.	PROPN
bibechana-29750	162	12	,	,	PUNCT
bibechana-29750	162	13	computer	computer	NOUN
bibechana-29750	162	14	simulation	simulation	NOUN
bibechana-29750	162	15	of	of	ADP
bibechana-29750	162	16	liquids	liquid	NOUN
bibechana-29750	162	17	,	,	PUNCT
bibechana-29750	162	18	oxford	oxford	PROPN
bibechana-29750	162	19	university	university	PROPN
bibechana-29750	162	20	press	press	NOUN
bibechana-29750	162	21	,	,	PUNCT
bibechana-29750	162	22	new	new	PROPN
bibechana-29750	162	23	york	york	PROPN
bibechana-29750	162	24	(	(	PUNCT
bibechana-29750	162	25	1987	1987	NUM
bibechana-29750	162	26	)	)	PUNCT
bibechana-29750	162	27	.	.	PUNCT
bibechana-29750	163	1	[	[	X
bibechana-29750	163	2	14	14	NUM
bibechana-29750	163	3	]	]	X
bibechana-29750	163	4	d.	d.	PROPN
bibechana-29750	163	5	frenkel	frenkel	PROPN
bibechana-29750	163	6	,	,	PUNCT
bibechana-29750	163	7	b.	b.	PROPN
bibechana-29750	163	8	smit	smit	PROPN
bibechana-29750	163	9	,	,	PUNCT
bibechana-29750	163	10	understanding	understand	VERB
bibechana-29750	163	11	molecular	molecular	ADJ
bibechana-29750	163	12	simulation	simulation	NOUN
bibechana-29750	163	13	from	from	ADP
bibechana-29750	163	14	algorithms	algorithm	NOUN
bibechana-29750	163	15	to	to	ADP
bibechana-29750	163	16	applications	application	NOUN
bibechana-29750	163	17	2nd	2nd	PROPN
bibechana-29750	163	18	ed	ed	NOUN
bibechana-29750	163	19	;	;	PUNCT
bibechana-29750	163	20	academic	academic	ADJ
bibechana-29750	163	21	press	press	NOUN
bibechana-29750	163	22	;	;	PUNCT
bibechana-29750	163	23	san	san	PROPN
bibechana-29750	163	24	diago	diago	PROPN
bibechana-29750	163	25	,	,	PUNCT
bibechana-29750	163	26	usa	usa	PROPN
bibechana-29750	163	27	(	(	PUNCT
bibechana-29750	163	28	2002	2002	NUM
bibechana-29750	163	29	)	)	PUNCT
bibechana-29750	163	30	.	.	PUNCT
bibechana-29750	164	1	[	[	X
bibechana-29750	164	2	15	15	NUM
bibechana-29750	164	3	]	]	X
bibechana-29750	164	4	c.	c.	PROPN
bibechana-29750	164	5	james	james	PROPN
bibechana-29750	164	6	phillips	phillips	PROPN
bibechana-29750	164	7	,	,	PUNCT
bibechana-29750	164	8	rosemary	rosemary	ADJ
bibechana-29750	164	9	braun	braun	NOUN
bibechana-29750	164	10	,	,	PUNCT
bibechana-29750	164	11	wei	wei	PROPN
bibechana-29750	164	12	wang	wang	PROPN
bibechana-29750	164	13	,	,	PUNCT
bibechana-29750	164	14	james	james	PROPN
bibechana-29750	164	15	gumbart	gumbart	PROPN
bibechana-29750	164	16	,	,	PUNCT
bibechana-29750	164	17	emad	emad	PROPN
bibechana-29750	164	18	tajkhorshid	tajkhorshid	PROPN
bibechana-29750	164	19	,	,	PUNCT
bibechana-29750	164	20	elizabeth	elizabeth	PROPN
bibechana-29750	164	21	villa	villa	PROPN
bibechana-29750	164	22	,	,	PUNCT
bibechana-29750	164	23	christophe	christophe	PROPN
bibechana-29750	164	24	chipot	chipot	PROPN
bibechana-29750	164	25	,	,	PUNCT
bibechana-29750	164	26	robert	robert	PROPN
bibechana-29750	164	27	d.	d.	PROPN
bibechana-29750	164	28	skeel	skeel	PROPN
bibechana-29750	164	29	,	,	PUNCT
bibechana-29750	164	30	laxmikant	laxmikant	ADJ
bibechana-29750	164	31	kale	kale	NOUN
bibechana-29750	164	32	,	,	PUNCT
bibechana-29750	164	33	and	and	CCONJ
bibechana-29750	164	34	klaus	klaus	PROPN
bibechana-29750	164	35	schulten	schulten	PROPN
bibechana-29750	164	36	.	.	PUNCT
bibechana-29750	165	1	scalable	scalable	ADJ
bibechana-29750	165	2	molecular	molecular	ADJ
bibechana-29750	165	3	dynamics	dynamic	NOUN
bibechana-29750	165	4	with	with	ADP
bibechana-29750	165	5	namd	namd	ADJ
bibechana-29750	165	6	.	.	PROPN
bibechana-29750	165	7	journal	journal	PROPN
bibechana-29750	165	8	of	of	ADP
bibechana-29750	165	9	computational	computational	ADJ
bibechana-29750	165	10	chemistry	chemistry	NOUN
bibechana-29750	165	11	26	26	NUM
bibechana-29750	165	12	(	(	PUNCT
bibechana-29750	165	13	2005)1781	2005)1781	NUM
bibechana-29750	165	14	-	-	SYM
bibechana-29750	165	15	1802	1802	NUM
bibechana-29750	165	16	.	.	PUNCT
bibechana-29750	166	1	www.ks.uiuc.edu/training/tutorials(retrivedonju	www.ks.uiuc.edu/training/tutorials(retrivedonju	VERB
bibechana-29750	167	1	ne10th2020	ne10th2020	NOUN
bibechana-29750	168	1	[	[	X
bibechana-29750	168	2	16	16	NUM
bibechana-29750	168	3	]	]	PUNCT
bibechana-29750	168	4	k.	k.	PROPN
bibechana-29750	168	5	huang	huang	PROPN
bibechana-29750	168	6	,	,	PUNCT
bibechana-29750	168	7	statistical	statistical	ADJ
bibechana-29750	168	8	mechanics	mechanic	NOUN
bibechana-29750	168	9	,	,	PUNCT
bibechana-29750	168	10	john	john	PROPN
bibechana-29750	168	11	wiley	wiley	PROPN
bibechana-29750	168	12	&	&	CCONJ
bibechana-29750	168	13	sons	son	NOUN
bibechana-29750	168	14	,	,	PUNCT
bibechana-29750	168	15	new	new	PROPN
bibechana-29750	168	16	york	york	PROPN
bibechana-29750	168	17	(	(	PUNCT
bibechana-29750	168	18	1987	1987	NUM
bibechana-29750	168	19	)	)	PUNCT
bibechana-29750	168	20	.	.	PUNCT
bibechana-29750	169	1	[	[	X
bibechana-29750	169	2	17	17	NUM
bibechana-29750	169	3	]	]	PUNCT
bibechana-29750	169	4	j.	j.	PROPN
bibechana-29750	169	5	c.	c.	PROPN
bibechana-29750	169	6	phillips	phillips	PROPN
bibechana-29750	169	7	et	et	PROPN
bibechana-29750	169	8	al	al	PROPN
bibechana-29750	169	9	.	.	PROPN
bibechana-29750	169	10	,	,	PUNCT
bibechana-29750	169	11	scalable	scalable	ADJ
bibechana-29750	169	12	molecular	molecular	ADJ
bibechana-29750	169	13	dynamics	dynamic	NOUN
bibechana-29750	169	14	with	with	ADP
bibechana-29750	169	15	namd	namd	NOUN
bibechana-29750	169	16	,	,	PUNCT
bibechana-29750	169	17	j.	j.	PROPN
bibechana-29750	169	18	comp	comp	PROPN
bibechana-29750	169	19	.	.	PUNCT
bibechana-29750	170	1	chem	chem	PROPN
bibechana-29750	170	2	.	.	PUNCT
bibechana-29750	171	1	26	26	NUM
bibechana-29750	171	2	(	(	PUNCT
bibechana-29750	171	3	2005	2005	NUM
bibechana-29750	171	4	)	)	PUNCT
bibechana-29750	171	5	17811802	17811802	NUM
bibechana-29750	171	6	.	.	PUNCT
bibechana-29750	172	1	http://www.google.com/sickle	http://www.google.com/sickle	PROPN
bibechana-29750	172	2	http://www.ks.uiuc.edu/t	http://www.ks.uiuc.edu/t	PROPN
bibechana-29750	172	3	http://www.ks.uiuc.edu/t	http://www.ks.uiuc.edu/t	NOUN