id	sid	tid	token	lemma	pos
bibechana-68838	1	1	bibechana	bibechana	PROPN
bibechana-68838	1	2	vol	vol	NOUN
bibechana-68838	1	3	.	.	PROPN
bibechana-68838	2	1	21	21	NUM
bibechana-68838	2	2	,	,	PUNCT
bibechana-68838	2	3	no	no	INTJ
bibechana-68838	2	4	.	.	NOUN
bibechana-68838	2	5	3	3	NUM
bibechana-68838	2	6	,	,	PUNCT
bibechana-68838	2	7	december	december	PROPN
bibechana-68838	2	8	2024	2024	NUM
bibechana-68838	2	9	,	,	PUNCT
bibechana-68838	2	10	290	290	NUM
bibechana-68838	2	11	-	-	SYM
bibechana-68838	2	12	299	299	NUM
bibechana-68838	2	13	issn	issn	PROPN
bibechana-68838	2	14	2091	2091	NUM
bibechana-68838	2	15	-	-	SYM
bibechana-68838	2	16	0762	0762	NUM
bibechana-68838	2	17	(	(	PUNCT
bibechana-68838	2	18	print	print	NOUN
bibechana-68838	2	19	)	)	PUNCT
bibechana-68838	2	20	,	,	PUNCT
bibechana-68838	2	21	2382	2382	NUM
bibechana-68838	2	22	-	-	SYM
bibechana-68838	2	23	5340	5340	NUM
bibechana-68838	2	24	(	(	PUNCT
bibechana-68838	2	25	online	online	ADJ
bibechana-68838	2	26	)	)	PUNCT
bibechana-68838	2	27	journal	journal	NOUN
bibechana-68838	2	28	homepage	homepage	NOUN
bibechana-68838	2	29	:	:	PUNCT
bibechana-68838	2	30	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-68838	2	31	publisher	publisher	NOUN
bibechana-68838	2	32	:	:	PUNCT
bibechana-68838	2	33	dept	dept	NOUN
bibechana-68838	2	34	.	.	PROPN
bibechana-68838	2	35	of	of	ADP
bibechana-68838	2	36	phys	phy	NOUN
bibechana-68838	2	37	.	.	PUNCT
bibechana-68838	2	38	,	,	PUNCT
bibechana-68838	2	39	mahendra	mahendra	PROPN
bibechana-68838	2	40	morang	morang	PROPN
bibechana-68838	2	41	a.	a.	PROPN
bibechana-68838	2	42	m.	m.	PROPN
bibechana-68838	2	43	campus	campus	PROPN
bibechana-68838	2	44	(	(	PUNCT
bibechana-68838	2	45	tribhuvan	tribhuvan	NOUN
bibechana-68838	2	46	university)biratnagar	university)biratnagar	NUM
bibechana-68838	2	47	characterization	characterization	NOUN
bibechana-68838	2	48	of	of	ADP
bibechana-68838	2	49	the	the	DET
bibechana-68838	2	50	molecular	molecular	ADJ
bibechana-68838	2	51	interactions	interaction	NOUN
bibechana-68838	2	52	between	between	ADP
bibechana-68838	2	53	kaiso	kaiso	NOUN
bibechana-68838	2	54	and	and	CCONJ
bibechana-68838	2	55	ctcf	ctcf	NOUN
bibechana-68838	2	56	using	use	VERB
bibechana-68838	2	57	alphafold2	alphafold2	PROPN
bibechana-68838	2	58	and	and	CCONJ
bibechana-68838	2	59	molecular	molecular	ADJ
bibechana-68838	2	60	dynamics	dynamic	NOUN
bibechana-68838	2	61	simulations	simulation	NOUN
bibechana-68838	2	62	bidhya	bidhya	NOUN
bibechana-68838	2	63	thapa1,2	thapa1,2	PROPN
bibechana-68838	2	64	,	,	PUNCT
bibechana-68838	2	65	narayan	narayan	PROPN
bibechana-68838	2	66	prasad	prasad	PROPN
bibechana-68838	2	67	adhikari1,∗	adhikari1,∗	PROPN
bibechana-68838	2	68	1central	1central	PROPN
bibechana-68838	2	69	department	department	PROPN
bibechana-68838	2	70	of	of	ADP
bibechana-68838	2	71	physics	physics	PROPN
bibechana-68838	2	72	,	,	PUNCT
bibechana-68838	2	73	tribhuvan	tribhuvan	PROPN
bibechana-68838	2	74	university	university	PROPN
bibechana-68838	2	75	,	,	PUNCT
bibechana-68838	2	76	kirtipur	kirtipur	NOUN
bibechana-68838	2	77	,	,	PUNCT
bibechana-68838	2	78	kathmandu	kathmandu	NOUN
bibechana-68838	2	79	,	,	PUNCT
bibechana-68838	2	80	nepal	nepal	NOUN
bibechana-68838	2	81	2padma	2padma	NUM
bibechana-68838	2	82	kanya	kanya	PROPN
bibechana-68838	2	83	multiple	multiple	PROPN
bibechana-68838	2	84	campus	campus	PROPN
bibechana-68838	2	85	,	,	PUNCT
bibechana-68838	2	86	tribhuvan	tribhuvan	PROPN
bibechana-68838	2	87	university	university	PROPN
bibechana-68838	2	88	,	,	PUNCT
bibechana-68838	2	89	bagbazar	bagbazar	NOUN
bibechana-68838	2	90	,	,	PUNCT
bibechana-68838	2	91	kathmandu	kathmandu	NOUN
bibechana-68838	2	92	,	,	PUNCT
bibechana-68838	2	93	nepal	nepal	ADJ
bibechana-68838	2	94	∗corresponding	∗corresponde	VERB
bibechana-68838	2	95	author	author	NOUN
bibechana-68838	2	96	.	.	PUNCT
bibechana-68838	3	1	email	email	NOUN
bibechana-68838	3	2	:	:	PUNCT
bibechana-68838	3	3	narayan.adhikari@cdp.tu.edu.np	narayan.adhikari@cdp.tu.edu.np	ADJ
bibechana-68838	3	4	abstract	abstract	ADJ
bibechana-68838	3	5	zinc	zinc	NOUN
bibechana-68838	3	6	finger	finger	NOUN
bibechana-68838	3	7	(	(	PUNCT
bibechana-68838	3	8	zf	zf	PROPN
bibechana-68838	3	9	)	)	PUNCT
bibechana-68838	3	10	protein	protein	NOUN
bibechana-68838	3	11	ctcf	ctcf	NOUN
bibechana-68838	3	12	is	be	AUX
bibechana-68838	3	13	an	an	DET
bibechana-68838	3	14	architectural	architectural	ADJ
bibechana-68838	3	15	protein	protein	NOUN
bibechana-68838	3	16	that	that	PRON
bibechana-68838	3	17	plays	play	VERB
bibechana-68838	3	18	a	a	DET
bibechana-68838	3	19	crucial	crucial	ADJ
bibechana-68838	3	20	role	role	NOUN
bibechana-68838	3	21	in	in	ADP
bibechana-68838	3	22	global	global	ADJ
bibechana-68838	3	23	chromatin	chromatin	NOUN
bibechana-68838	3	24	organization	organization	NOUN
bibechana-68838	3	25	and	and	CCONJ
bibechana-68838	3	26	remodeling	remodeling	NOUN
bibechana-68838	3	27	via	via	ADP
bibechana-68838	3	28	its	its	PRON
bibechana-68838	3	29	interaction	interaction	NOUN
bibechana-68838	3	30	with	with	ADP
bibechana-68838	3	31	several	several	ADJ
bibechana-68838	3	32	protein	protein	NOUN
bibechana-68838	3	33	partners	partner	NOUN
bibechana-68838	3	34	.	.	PUNCT
bibechana-68838	4	1	the	the	DET
bibechana-68838	4	2	interaction	interaction	NOUN
bibechana-68838	4	3	between	between	ADP
bibechana-68838	4	4	kaiso	kaiso	NOUN
bibechana-68838	4	5	and	and	CCONJ
bibechana-68838	4	6	ctcf	ctcf	NOUN
bibechana-68838	4	7	regulates	regulate	VERB
bibechana-68838	4	8	the	the	DET
bibechana-68838	4	9	enhancer	enhancer	NOUN
bibechana-68838	4	10	-	-	PUNCT
bibechana-68838	4	11	blocking	block	VERB
bibechana-68838	4	12	function	function	NOUN
bibechana-68838	4	13	of	of	ADP
bibechana-68838	4	14	ctcf	ctcf	NOUN
bibechana-68838	4	15	.	.	PUNCT
bibechana-68838	5	1	despite	despite	SCONJ
bibechana-68838	5	2	the	the	DET
bibechana-68838	5	3	important	important	ADJ
bibechana-68838	5	4	biological	biological	ADJ
bibechana-68838	5	5	function	function	NOUN
bibechana-68838	5	6	of	of	ADP
bibechana-68838	5	7	their	their	PRON
bibechana-68838	5	8	interactions	interaction	NOUN
bibechana-68838	5	9	,	,	PUNCT
bibechana-68838	5	10	structural	structural	ADJ
bibechana-68838	5	11	characterization	characterization	NOUN
bibechana-68838	5	12	of	of	ADP
bibechana-68838	5	13	the	the	DET
bibechana-68838	5	14	kaiso	kaiso	NOUN
bibechana-68838	5	15	-	-	PUNCT
bibechana-68838	5	16	ctcf	ctcf	NOUN
bibechana-68838	5	17	complex	complex	NOUN
bibechana-68838	5	18	has	have	VERB
bibechana-68838	5	19	yet	yet	ADV
bibechana-68838	5	20	to	to	PART
bibechana-68838	5	21	be	be	AUX
bibechana-68838	5	22	carried	carry	VERB
bibechana-68838	5	23	out	out	ADP
bibechana-68838	5	24	.	.	PUNCT
bibechana-68838	6	1	in	in	ADP
bibechana-68838	6	2	this	this	DET
bibechana-68838	6	3	work	work	NOUN
bibechana-68838	6	4	,	,	PUNCT
bibechana-68838	6	5	we	we	PRON
bibechana-68838	6	6	have	have	AUX
bibechana-68838	6	7	employed	employ	VERB
bibechana-68838	6	8	molecular	molecular	ADJ
bibechana-68838	6	9	modeling	modeling	NOUN
bibechana-68838	6	10	and	and	CCONJ
bibechana-68838	6	11	md	md	PROPN
bibechana-68838	6	12	simulation	simulation	NOUN
bibechana-68838	6	13	to	to	PART
bibechana-68838	6	14	predict	predict	VERB
bibechana-68838	6	15	the	the	DET
bibechana-68838	6	16	complex	complex	NOUN
bibechana-68838	6	17	between	between	ADP
bibechana-68838	6	18	kaiso	kaiso	NOUN
bibechana-68838	6	19	and	and	CCONJ
bibechana-68838	6	20	ctcf	ctcf	VERB
bibechana-68838	6	21	and	and	CCONJ
bibechana-68838	6	22	investigate	investigate	VERB
bibechana-68838	6	23	its	its	PRON
bibechana-68838	6	24	structural	structural	ADJ
bibechana-68838	6	25	features	feature	NOUN
bibechana-68838	6	26	.	.	PUNCT
bibechana-68838	7	1	we	we	PRON
bibechana-68838	7	2	have	have	AUX
bibechana-68838	7	3	employed	employ	VERB
bibechana-68838	7	4	alphafold2	alphafold2	NOUN
bibechana-68838	7	5	to	to	PART
bibechana-68838	7	6	predict	predict	VERB
bibechana-68838	7	7	the	the	DET
bibechana-68838	7	8	optimum	optimum	ADJ
bibechana-68838	7	9	complex	complex	NOUN
bibechana-68838	7	10	between	between	ADP
bibechana-68838	7	11	kaiso	kaiso	NOUN
bibechana-68838	7	12	and	and	CCONJ
bibechana-68838	7	13	ctcf	ctcf	NOUN
bibechana-68838	7	14	and	and	CCONJ
bibechana-68838	7	15	md	md	PROPN
bibechana-68838	7	16	simulation	simulation	NOUN
bibechana-68838	7	17	to	to	PART
bibechana-68838	7	18	explore	explore	VERB
bibechana-68838	7	19	the	the	DET
bibechana-68838	7	20	detailed	detailed	ADJ
bibechana-68838	7	21	dynamics	dynamic	NOUN
bibechana-68838	7	22	of	of	ADP
bibechana-68838	7	23	the	the	DET
bibechana-68838	7	24	interaction	interaction	NOUN
bibechana-68838	7	25	involved	involve	VERB
bibechana-68838	7	26	in	in	ADP
bibechana-68838	7	27	complex	complex	ADJ
bibechana-68838	7	28	formation	formation	NOUN
bibechana-68838	7	29	and	and	CCONJ
bibechana-68838	7	30	stabilization	stabilization	NOUN
bibechana-68838	7	31	.	.	PUNCT
bibechana-68838	8	1	we	we	PRON
bibechana-68838	8	2	predicted	predict	VERB
bibechana-68838	8	3	the	the	DET
bibechana-68838	8	4	key	key	ADJ
bibechana-68838	8	5	residues	residue	NOUN
bibechana-68838	8	6	and	and	CCONJ
bibechana-68838	8	7	their	their	PRON
bibechana-68838	8	8	interactions	interaction	NOUN
bibechana-68838	8	9	involved	involve	VERB
bibechana-68838	8	10	in	in	ADP
bibechana-68838	8	11	the	the	DET
bibechana-68838	8	12	binding	binding	NOUN
bibechana-68838	8	13	of	of	ADP
bibechana-68838	8	14	kaiso	kaiso	NOUN
bibechana-68838	8	15	to	to	PART
bibechana-68838	8	16	ctcf	ctcf	VERB
bibechana-68838	8	17	.	.	PUNCT
bibechana-68838	9	1	our	our	PRON
bibechana-68838	9	2	results	result	NOUN
bibechana-68838	9	3	show	show	VERB
bibechana-68838	9	4	that	that	SCONJ
bibechana-68838	9	5	the	the	DET
bibechana-68838	9	6	hydrophobic	hydrophobic	NOUN
bibechana-68838	9	7	interaction	interaction	NOUN
bibechana-68838	9	8	between	between	ADP
bibechana-68838	9	9	the	the	DET
bibechana-68838	9	10	inter	inter	ADJ
bibechana-68838	9	11	-	-	ADJ
bibechana-68838	9	12	facial	facial	ADJ
bibechana-68838	9	13	residues	residue	NOUN
bibechana-68838	9	14	plays	play	VERB
bibechana-68838	9	15	a	a	DET
bibechana-68838	9	16	significant	significant	ADJ
bibechana-68838	9	17	role	role	NOUN
bibechana-68838	9	18	in	in	ADP
bibechana-68838	9	19	forming	form	VERB
bibechana-68838	9	20	the	the	DET
bibechana-68838	9	21	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	9	22	complex	complex	NOUN
bibechana-68838	9	23	.	.	PUNCT
bibechana-68838	10	1	in	in	ADP
bibechana-68838	10	2	addition	addition	NOUN
bibechana-68838	10	3	,	,	PUNCT
bibechana-68838	10	4	several	several	ADJ
bibechana-68838	10	5	non	non	ADJ
bibechana-68838	10	6	-	-	ADJ
bibechana-68838	10	7	covalent	covalent	ADJ
bibechana-68838	10	8	interactions	interaction	NOUN
bibechana-68838	10	9	,	,	PUNCT
bibechana-68838	10	10	such	such	ADJ
bibechana-68838	10	11	as	as	ADP
bibechana-68838	10	12	hydrogen	hydrogen	NOUN
bibechana-68838	10	13	bonds	bond	NOUN
bibechana-68838	10	14	and	and	CCONJ
bibechana-68838	10	15	electrostatic	electrostatic	ADJ
bibechana-68838	10	16	and	and	CCONJ
bibechana-68838	10	17	van	van	PROPN
bibechana-68838	10	18	der	der	NOUN
bibechana-68838	10	19	waals	waal	NOUN
bibechana-68838	10	20	interactions	interaction	NOUN
bibechana-68838	10	21	,	,	PUNCT
bibechana-68838	10	22	stabilize	stabilize	VERB
bibechana-68838	10	23	the	the	DET
bibechana-68838	10	24	complex	complex	NOUN
bibechana-68838	10	25	.	.	PUNCT
bibechana-68838	11	1	the	the	DET
bibechana-68838	11	2	significant	significant	ADJ
bibechana-68838	11	3	value	value	NOUN
bibechana-68838	11	4	of	of	ADP
bibechana-68838	11	5	hydrophobic	hydrophobic	NOUN
bibechana-68838	11	6	contact	contact	NOUN
bibechana-68838	11	7	area	area	NOUN
bibechana-68838	11	8	and	and	CCONJ
bibechana-68838	11	9	binding	bind	VERB
bibechana-68838	11	10	free	free	ADJ
bibechana-68838	11	11	energy	energy	NOUN
bibechana-68838	11	12	signifies	signify	VERB
bibechana-68838	11	13	the	the	DET
bibechana-68838	11	14	stability	stability	NOUN
bibechana-68838	11	15	of	of	ADP
bibechana-68838	11	16	the	the	DET
bibechana-68838	11	17	predicted	predict	VERB
bibechana-68838	11	18	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	11	19	complex	complex	PROPN
bibechana-68838	11	20	.	.	PUNCT
bibechana-68838	12	1	keywords	keyword	VERB
bibechana-68838	12	2	kaiso	kaiso	NOUN
bibechana-68838	12	3	,	,	PUNCT
bibechana-68838	12	4	ctcf	ctcf	ADJ
bibechana-68838	12	5	,	,	PUNCT
bibechana-68838	12	6	protein	protein	NOUN
bibechana-68838	12	7	-	-	PUNCT
bibechana-68838	12	8	protein	protein	NOUN
bibechana-68838	12	9	interactions	interaction	NOUN
bibechana-68838	12	10	,	,	PUNCT
bibechana-68838	12	11	alphafold2	alphafold2	PROPN
bibechana-68838	12	12	,	,	PUNCT
bibechana-68838	12	13	md	md	PROPN
bibechana-68838	12	14	simulation	simulation	PROPN
bibechana-68838	12	15	.	.	PUNCT
bibechana-68838	13	1	article	article	NOUN
bibechana-68838	13	2	information	information	PROPN
bibechana-68838	13	3	manuscript	manuscript	PROPN
bibechana-68838	13	4	received	receive	VERB
bibechana-68838	13	5	:	:	PUNCT
bibechana-68838	13	6	august	august	PROPN
bibechana-68838	13	7	16	16	NUM
bibechana-68838	13	8	,	,	PUNCT
bibechana-68838	13	9	2024	2024	NUM
bibechana-68838	13	10	;	;	PUNCT
bibechana-68838	13	11	september	september	PROPN
bibechana-68838	13	12	5	5	NUM
bibechana-68838	13	13	,	,	PUNCT
bibechana-68838	13	14	2024	2024	NUM
bibechana-68838	13	15	;	;	PUNCT
bibechana-68838	13	16	accepted	accept	VERB
bibechana-68838	13	17	:	:	PUNCT
bibechana-68838	13	18	september	september	PROPN
bibechana-68838	13	19	14	14	NUM
bibechana-68838	13	20	,	,	PUNCT
bibechana-68838	13	21	2024	2024	NUM
bibechana-68838	13	22	doi	doi	NOUN
bibechana-68838	13	23	https://doi.org/10.3126/bibechana.v21i3.68838	https://doi.org/10.3126/bibechana.v21i3.68838	PRON
bibechana-68838	13	24	this	this	DET
bibechana-68838	13	25	work	work	NOUN
bibechana-68838	13	26	is	be	AUX
bibechana-68838	13	27	licensed	license	VERB
bibechana-68838	13	28	under	under	ADP
bibechana-68838	13	29	the	the	DET
bibechana-68838	13	30	creative	creative	ADJ
bibechana-68838	13	31	commons	common	NOUN
bibechana-68838	13	32	cc	cc	ADP
bibechana-68838	13	33	by	by	ADP
bibechana-68838	13	34	-	-	PUNCT
bibechana-68838	13	35	nc	nc	NOUN
bibechana-68838	13	36	license	license	NOUN
bibechana-68838	13	37	.	.	PUNCT
bibechana-68838	14	1	https://creativecommons	https://creativecommon	NOUN
bibechana-68838	14	2	.	.	PUNCT
bibechana-68838	14	3	org	org	ADJ
bibechana-68838	14	4	/	/	SYM
bibechana-68838	14	5	licenses	license	NOUN
bibechana-68838	14	6	/	/	SYM
bibechana-68838	14	7	by	by	ADP
bibechana-68838	14	8	-	-	PUNCT
bibechana-68838	14	9	nc/4.0/	nc/4.0/	NOUN
bibechana-68838	14	10	1	1	NUM
bibechana-68838	14	11	introduction	introduction	NOUN
bibechana-68838	14	12	zinc	zinc	NOUN
bibechana-68838	14	13	finger	finger	NOUN
bibechana-68838	14	14	(	(	PUNCT
bibechana-68838	14	15	zf	zf	PROPN
bibechana-68838	14	16	)	)	PUNCT
bibechana-68838	14	17	protein	protein	NOUN
bibechana-68838	14	18	kaiso	kaiso	NOUN
bibechana-68838	14	19	is	be	AUX
bibechana-68838	14	20	a	a	DET
bibechana-68838	14	21	transcription	transcription	NOUN
bibechana-68838	14	22	factor	factor	NOUN
bibechana-68838	14	23	that	that	PRON
bibechana-68838	14	24	regulates	regulate	VERB
bibechana-68838	14	25	various	various	ADJ
bibechana-68838	14	26	cellular	cellular	ADJ
bibechana-68838	14	27	functions	function	NOUN
bibechana-68838	14	28	,	,	PUNCT
bibechana-68838	14	29	such	such	ADJ
bibechana-68838	14	30	as	as	ADP
bibechana-68838	14	31	gene	gene	NOUN
bibechana-68838	14	32	expression	expression	NOUN
bibechana-68838	14	33	,	,	PUNCT
bibechana-68838	14	34	cellular	cellular	ADJ
bibechana-68838	14	35	differentiation	differentiation	NOUN
bibechana-68838	14	36	,	,	PUNCT
bibechana-68838	14	37	development	development	NOUN
bibechana-68838	14	38	,	,	PUNCT
bibechana-68838	14	39	and	and	CCONJ
bibechana-68838	14	40	cancer	cancer	NOUN
bibechana-68838	14	41	progression	progression	NOUN
bibechana-68838	14	42	[	[	X
bibechana-68838	14	43	1–7	1–7	NUM
bibechana-68838	14	44	]	]	PUNCT
bibechana-68838	14	45	.	.	PUNCT
bibechana-68838	15	1	kaiso	kaiso	PROPN
bibechana-68838	15	2	was	be	AUX
bibechana-68838	15	3	first	first	ADV
bibechana-68838	15	4	identified	identify	VERB
bibechana-68838	15	5	as	as	ADP
bibechana-68838	15	6	the	the	DET
bibechana-68838	15	7	binding	bind	VERB
bibechana-68838	15	8	partner	partner	NOUN
bibechana-68838	15	9	of	of	ADP
bibechana-68838	15	10	armadillo	armadillo	NOUN
bibechana-68838	15	11	repeat	repeat	NOUN
bibechana-68838	15	12	protein	protein	NOUN
bibechana-68838	15	13	p120	p120	PROPN
bibechana-68838	15	14	catenin	catenin	NOUN
bibechana-68838	16	1	[	[	X
bibechana-68838	16	2	3	3	NUM
bibechana-68838	16	3	]	]	PUNCT
bibechana-68838	16	4	.	.	PUNCT
bibechana-68838	17	1	it	it	PRON
bibechana-68838	17	2	contains	contain	VERB
bibechana-68838	17	3	three	three	NUM
bibechana-68838	17	4	classical	classical	ADJ
bibechana-68838	17	5	c2h2	c2h2	NOUN
bibechana-68838	17	6	zf	zf	PROPN
bibechana-68838	17	7	domains	domain	NOUN
bibechana-68838	17	8	that	that	PRON
bibechana-68838	17	9	are	be	AUX
bibechana-68838	17	10	involved	involve	VERB
bibechana-68838	17	11	in	in	ADP
bibechana-68838	17	12	dna	dna	PROPN
bibechana-68838	17	13	recognition	recognition	NOUN
bibechana-68838	17	14	and	and	CCONJ
bibechana-68838	17	15	binding	bind	VERB
bibechana-68838	17	16	[	[	X
bibechana-68838	17	17	4	4	NUM
bibechana-68838	17	18	,	,	PUNCT
bibechana-68838	17	19	8	8	NUM
bibechana-68838	17	20	]	]	PUNCT
bibechana-68838	17	21	.	.	PUNCT
bibechana-68838	18	1	the	the	DET
bibechana-68838	18	2	highly	highly	ADV
bibechana-68838	18	3	conserved	conserve	VERB
bibechana-68838	18	4	hydrophobic	hydrophobic	NOUN
bibechana-68838	18	5	n	n	CCONJ
bibechana-68838	18	6	-	-	PUNCT
bibechana-68838	18	7	terminal	terminal	ADJ
bibechana-68838	18	8	btb	btb	NOUN
bibechana-68838	18	9	/	/	SYM
bibechana-68838	18	10	poz	poz	PROPN
bibechana-68838	18	11	domain	domain	NOUN
bibechana-68838	18	12	is	be	AUX
bibechana-68838	18	13	involved	involve	VERB
bibechana-68838	18	14	in	in	ADP
bibechana-68838	18	15	interactions	interaction	NOUN
bibechana-68838	18	16	with	with	ADP
bibechana-68838	18	17	other	other	ADJ
bibechana-68838	18	18	proteins	protein	NOUN
bibechana-68838	18	19	290	290	NUM
bibechana-68838	18	20	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	NOUN
bibechana-68838	18	21	narayan.adhikari@cdp.tu.edu.np	narayan.adhikari@cdp.tu.edu.np	NOUN
bibechana-68838	18	22	https://doi.org/10.3126/bibechana.v21i3.68838	https://doi.org/10.3126/bibechana.v21i3.68838	NOUN
bibechana-68838	18	23	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PRON
bibechana-68838	18	24	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
bibechana-68838	18	25	bidhya	bidhya	NOUN
bibechana-68838	18	26	thapa	thapa	PROPN
bibechana-68838	18	27	and	and	CCONJ
bibechana-68838	18	28	narayan	narayan	PROPN
bibechana-68838	18	29	prasad	prasad	PROPN
bibechana-68838	18	30	adhikari/	adhikari/	NUM
bibechana-68838	18	31	bibechana	bibechana	NOUN
bibechana-68838	18	32	21	21	NUM
bibechana-68838	18	33	(	(	PUNCT
bibechana-68838	18	34	2024	2024	NUM
bibechana-68838	18	35	)	)	PUNCT
bibechana-68838	18	36	290	290	NUM
bibechana-68838	18	37	-	-	SYM
bibechana-68838	18	38	299	299	NUM
bibechana-68838	18	39	291	291	NUM
bibechana-68838	18	40	as	as	ADV
bibechana-68838	18	41	well	well	ADV
bibechana-68838	18	42	as	as	ADP
bibechana-68838	18	43	in	in	ADP
bibechana-68838	18	44	homodimerization	homodimerization	NOUN
bibechana-68838	18	45	[	[	X
bibechana-68838	18	46	9	9	NUM
bibechana-68838	18	47	]	]	PUNCT
bibechana-68838	18	48	.	.	PUNCT
bibechana-68838	19	1	kaiso	kaiso	NOUN
bibechana-68838	19	2	has	have	VERB
bibechana-68838	19	3	dual	dual	ADJ
bibechana-68838	19	4	specificity	specificity	NOUN
bibechana-68838	19	5	for	for	ADP
bibechana-68838	19	6	dna	dna	NOUN
bibechana-68838	19	7	binding	binding	NOUN
bibechana-68838	19	8	.	.	PUNCT
bibechana-68838	20	1	it	it	PRON
bibechana-68838	20	2	recognizes	recognize	VERB
bibechana-68838	20	3	the	the	DET
bibechana-68838	20	4	doubly	doubly	ADV
bibechana-68838	20	5	methylated	methylate	VERB
bibechana-68838	20	6	cpg	cpg	NOUN
bibechana-68838	20	7	dinucleotides	dinucleotide	VERB
bibechana-68838	20	8	(	(	PUNCT
bibechana-68838	20	9	mcpgmcpg	mcpgmcpg	PROPN
bibechana-68838	20	10	)	)	PUNCT
bibechana-68838	20	11	in	in	ADP
bibechana-68838	20	12	the	the	DET
bibechana-68838	20	13	core	core	NOUN
bibechana-68838	20	14	site	site	NOUN
bibechana-68838	20	15	as	as	ADV
bibechana-68838	20	16	well	well	ADV
bibechana-68838	20	17	as	as	ADP
bibechana-68838	20	18	the	the	DET
bibechana-68838	20	19	sequence	sequence	NOUN
bibechana-68838	20	20	-	-	PUNCT
bibechana-68838	20	21	specific	specific	ADJ
bibechana-68838	20	22	kaiso	kaiso	NOUN
bibechana-68838	20	23	binding	bind	VERB
bibechana-68838	20	24	site	site	NOUN
bibechana-68838	20	25	(	(	PUNCT
bibechana-68838	20	26	kbs	kbs	PROPN
bibechana-68838	20	27	)	)	PUNCT
bibechana-68838	20	28	,	,	PUNCT
bibechana-68838	20	29	having	have	VERB
bibechana-68838	20	30	the	the	DET
bibechana-68838	20	31	nucleotide	nucleotide	ADJ
bibechana-68838	20	32	sequence	sequence	NOUN
bibechana-68838	20	33	tcctgcna	tcctgcna	NOUN
bibechana-68838	20	34	,	,	PUNCT
bibechana-68838	20	35	in	in	ADP
bibechana-68838	20	36	dna	dna	NOUN
bibechana-68838	20	37	[	[	X
bibechana-68838	20	38	4	4	NUM
bibechana-68838	20	39	,	,	PUNCT
bibechana-68838	20	40	8	8	NUM
bibechana-68838	20	41	]	]	PUNCT
bibechana-68838	20	42	.	.	PUNCT
bibechana-68838	21	1	kaiso	kaiso	NOUN
bibechana-68838	21	2	recruits	recruit	VERB
bibechana-68838	21	3	nuclear	nuclear	ADJ
bibechana-68838	21	4	co	co	NOUN
bibechana-68838	21	5	-	-	NOUN
bibechana-68838	21	6	repressor	repressor	ADJ
bibechana-68838	21	7	complex	complex	NOUN
bibechana-68838	21	8	via	via	ADP
bibechana-68838	21	9	its	its	PRON
bibechana-68838	21	10	btb	btb	NOUN
bibechana-68838	21	11	/	/	SYM
bibechana-68838	21	12	poz	poz	PROPN
bibechana-68838	21	13	domain	domain	NOUN
bibechana-68838	21	14	to	to	PART
bibechana-68838	21	15	mediate	mediate	VERB
bibechana-68838	21	16	the	the	DET
bibechana-68838	21	17	transcription	transcription	NOUN
bibechana-68838	21	18	repression	repression	NOUN
bibechana-68838	21	19	in	in	ADP
bibechana-68838	21	20	a	a	DET
bibechana-68838	21	21	methylation	methylation	NOUN
bibechana-68838	21	22	-	-	PUNCT
bibechana-68838	21	23	dependent	dependent	ADJ
bibechana-68838	21	24	manner	manner	NOUN
bibechana-68838	22	1	[	[	X
bibechana-68838	22	2	9	9	NUM
bibechana-68838	22	3	]	]	PUNCT
bibechana-68838	22	4	.	.	PUNCT
bibechana-68838	23	1	depending	depend	VERB
bibechana-68838	23	2	on	on	ADP
bibechana-68838	23	3	the	the	DET
bibechana-68838	23	4	context	context	NOUN
bibechana-68838	23	5	and	and	CCONJ
bibechana-68838	23	6	cell	cell	NOUN
bibechana-68838	23	7	type	type	NOUN
bibechana-68838	23	8	,	,	PUNCT
bibechana-68838	23	9	it	it	PRON
bibechana-68838	23	10	acts	act	VERB
bibechana-68838	23	11	as	as	ADP
bibechana-68838	23	12	a	a	DET
bibechana-68838	23	13	transcription	transcription	NOUN
bibechana-68838	23	14	repressor	repressor	NOUN
bibechana-68838	23	15	[	[	NOUN
bibechana-68838	23	16	8–10	8–10	NOUN
bibechana-68838	23	17	]	]	PUNCT
bibechana-68838	23	18	or	or	CCONJ
bibechana-68838	23	19	an	an	DET
bibechana-68838	23	20	activator	activator	NOUN
bibechana-68838	23	21	[	[	X
bibechana-68838	23	22	11	11	NUM
bibechana-68838	23	23	]	]	PUNCT
bibechana-68838	23	24	.	.	PUNCT
bibechana-68838	24	1	kaiso	kaiso	PROPN
bibechana-68838	24	2	is	be	AUX
bibechana-68838	24	3	implicated	implicate	VERB
bibechana-68838	24	4	in	in	ADP
bibechana-68838	24	5	regulating	regulate	VERB
bibechana-68838	24	6	various	various	ADJ
bibechana-68838	24	7	genes	gene	NOUN
bibechana-68838	24	8	involved	involve	VERB
bibechana-68838	24	9	in	in	ADP
bibechana-68838	24	10	development	development	NOUN
bibechana-68838	24	11	and	and	CCONJ
bibechana-68838	24	12	cancer	cancer	NOUN
bibechana-68838	24	13	.	.	PUNCT
bibechana-68838	25	1	high	high	ADJ
bibechana-68838	25	2	levels	level	NOUN
bibechana-68838	25	3	of	of	ADP
bibechana-68838	25	4	kaiso	kaiso	NOUN
bibechana-68838	25	5	expression	expression	NOUN
bibechana-68838	25	6	are	be	AUX
bibechana-68838	25	7	observed	observe	VERB
bibechana-68838	25	8	in	in	ADP
bibechana-68838	25	9	multiple	multiple	ADJ
bibechana-68838	25	10	human	human	ADJ
bibechana-68838	25	11	cancers	cancer	NOUN
bibechana-68838	25	12	,	,	PUNCT
bibechana-68838	25	13	such	such	ADJ
bibechana-68838	25	14	as	as	ADP
bibechana-68838	25	15	lung	lung	NOUN
bibechana-68838	25	16	[	[	X
bibechana-68838	25	17	2	2	NUM
bibechana-68838	25	18	]	]	PUNCT
bibechana-68838	25	19	,	,	PUNCT
bibechana-68838	25	20	colon	colon	NOUN
bibechana-68838	25	21	[	[	NOUN
bibechana-68838	25	22	12	12	NUM
bibechana-68838	25	23	]	]	PUNCT
bibechana-68838	25	24	,	,	PUNCT
bibechana-68838	25	25	breast	breast	NOUN
bibechana-68838	26	1	[	[	X
bibechana-68838	26	2	1	1	NUM
bibechana-68838	26	3	]	]	PUNCT
bibechana-68838	26	4	,	,	PUNCT
bibechana-68838	26	5	and	and	CCONJ
bibechana-68838	26	6	prostate	prostate	NOUN
bibechana-68838	26	7	[	[	X
bibechana-68838	26	8	13	13	NUM
bibechana-68838	26	9	]	]	PUNCT
bibechana-68838	26	10	.	.	PUNCT
bibechana-68838	27	1	ccctcbinding	ccctcbinding	NOUN
bibechana-68838	27	2	factor	factor	NOUN
bibechana-68838	27	3	(	(	PUNCT
bibechana-68838	27	4	ctcf	ctcf	ADJ
bibechana-68838	27	5	)	)	PUNCT
bibechana-68838	27	6	protein	protein	NOUN
bibechana-68838	27	7	is	be	AUX
bibechana-68838	27	8	a	a	DET
bibechana-68838	27	9	ubiquitous	ubiquitous	ADJ
bibechana-68838	27	10	multi	multi	ADJ
bibechana-68838	27	11	-	-	ADJ
bibechana-68838	27	12	functional	functional	ADJ
bibechana-68838	27	13	transcription	transcription	NOUN
bibechana-68838	27	14	factor	factor	NOUN
bibechana-68838	27	15	that	that	PRON
bibechana-68838	27	16	binds	bind	VERB
bibechana-68838	27	17	with	with	ADP
bibechana-68838	27	18	the	the	DET
bibechana-68838	27	19	thousands	thousand	NOUN
bibechana-68838	27	20	of	of	ADP
bibechana-68838	27	21	tissue	tissue	NOUN
bibechana-68838	27	22	-	-	PUNCT
bibechana-68838	27	23	specific	specific	ADJ
bibechana-68838	27	24	and	and	CCONJ
bibechana-68838	27	25	conserved	conserved	ADJ
bibechana-68838	27	26	sites	site	NOUN
bibechana-68838	27	27	spread	spread	VERB
bibechana-68838	27	28	throughout	throughout	ADP
bibechana-68838	27	29	the	the	DET
bibechana-68838	27	30	genome	genome	NOUN
bibechana-68838	27	31	[	[	X
bibechana-68838	27	32	14–16	14–16	NUM
bibechana-68838	27	33	]	]	PUNCT
bibechana-68838	27	34	.	.	PUNCT
bibechana-68838	28	1	ctcf	ctcf	PROPN
bibechana-68838	28	2	was	be	AUX
bibechana-68838	28	3	initially	initially	ADV
bibechana-68838	28	4	identified	identify	VERB
bibechana-68838	28	5	as	as	ADP
bibechana-68838	28	6	the	the	DET
bibechana-68838	28	7	zf	zf	PROPN
bibechana-68838	28	8	protein	protein	NOUN
bibechana-68838	28	9	binding	bind	VERB
bibechana-68838	28	10	with	with	ADP
bibechana-68838	28	11	a	a	DET
bibechana-68838	28	12	ctc	ctc	NOUN
bibechana-68838	28	13	-	-	PUNCT
bibechana-68838	28	14	rich	rich	ADJ
bibechana-68838	28	15	sequence	sequence	NOUN
bibechana-68838	28	16	in	in	ADP
bibechana-68838	28	17	the	the	DET
bibechana-68838	28	18	c	c	NOUN
bibechana-68838	28	19	-	-	PUNCT
bibechana-68838	28	20	myc	myc	NOUN
bibechana-68838	28	21	promoter	promoter	NOUN
bibechana-68838	28	22	[	[	X
bibechana-68838	28	23	17	17	NUM
bibechana-68838	28	24	]	]	PUNCT
bibechana-68838	28	25	.	.	PUNCT
bibechana-68838	29	1	it	it	PRON
bibechana-68838	29	2	is	be	AUX
bibechana-68838	29	3	a	a	DET
bibechana-68838	29	4	727	727	NUM
bibechana-68838	29	5	amino	amino	NOUN
bibechana-68838	29	6	acid	acid	NOUN
bibechana-68838	29	7	long	long	ADJ
bibechana-68838	29	8	protein	protein	NOUN
bibechana-68838	29	9	containing	contain	VERB
bibechana-68838	29	10	11	11	NUM
bibechana-68838	29	11	zf	zf	PROPN
bibechana-68838	29	12	domains	domain	NOUN
bibechana-68838	29	13	,	,	PUNCT
bibechana-68838	29	14	two	two	NUM
bibechana-68838	29	15	transcriptions	transcription	NOUN
bibechana-68838	29	16	repression	repression	NOUN
bibechana-68838	29	17	domains	domain	NOUN
bibechana-68838	29	18	,	,	PUNCT
bibechana-68838	29	19	and	and	CCONJ
bibechana-68838	29	20	nand	nand	VERB
bibechana-68838	29	21	c	c	X
bibechana-68838	29	22	-	-	PUNCT
bibechana-68838	29	23	terminal	terminal	ADJ
bibechana-68838	29	24	unstructured	unstructured	ADJ
bibechana-68838	29	25	loops	loop	NOUN
bibechana-68838	29	26	[	[	X
bibechana-68838	29	27	18	18	NUM
bibechana-68838	29	28	]	]	PUNCT
bibechana-68838	29	29	.	.	PUNCT
bibechana-68838	30	1	specifically	specifically	ADV
bibechana-68838	30	2	,	,	PUNCT
bibechana-68838	30	3	zf	zf	PROPN
bibechana-68838	30	4	4	4	NUM
bibechana-68838	30	5	-	-	SYM
bibechana-68838	30	6	7	7	NUM
bibechana-68838	30	7	are	be	AUX
bibechana-68838	30	8	directly	directly	ADV
bibechana-68838	30	9	involved	involve	VERB
bibechana-68838	30	10	in	in	ADP
bibechana-68838	30	11	dna	dna	NOUN
bibechana-68838	30	12	binding	bind	VERB
bibechana-68838	30	13	,	,	PUNCT
bibechana-68838	30	14	whereas	whereas	SCONJ
bibechana-68838	30	15	other	other	ADJ
bibechana-68838	30	16	zf	zf	PROPN
bibechana-68838	30	17	domains	domain	NOUN
bibechana-68838	30	18	enhance	enhance	VERB
bibechana-68838	30	19	the	the	DET
bibechana-68838	30	20	stability	stability	NOUN
bibechana-68838	30	21	of	of	ADP
bibechana-68838	30	22	the	the	DET
bibechana-68838	30	23	ctcfdna	ctcfdna	NOUN
bibechana-68838	30	24	complex	complex	NOUN
bibechana-68838	31	1	[	[	X
bibechana-68838	31	2	19	19	NUM
bibechana-68838	31	3	]	]	PUNCT
bibechana-68838	31	4	.	.	PUNCT
bibechana-68838	32	1	the	the	DET
bibechana-68838	32	2	ctcf	ctcf	ADJ
bibechana-68838	32	3	binding	bind	VERB
bibechana-68838	32	4	sites	site	NOUN
bibechana-68838	32	5	are	be	AUX
bibechana-68838	32	6	primarily	primarily	ADV
bibechana-68838	32	7	present	present	ADJ
bibechana-68838	32	8	in	in	ADP
bibechana-68838	32	9	intergenic	intergenic	ADJ
bibechana-68838	32	10	regions	region	NOUN
bibechana-68838	32	11	but	but	CCONJ
bibechana-68838	32	12	also	also	ADV
bibechana-68838	32	13	in	in	ADP
bibechana-68838	32	14	the	the	DET
bibechana-68838	32	15	enhancer	enhancer	NOUN
bibechana-68838	32	16	,	,	PUNCT
bibechana-68838	32	17	promoter	promoter	NOUN
bibechana-68838	32	18	,	,	PUNCT
bibechana-68838	32	19	and	and	CCONJ
bibechana-68838	32	20	within	within	ADP
bibechana-68838	32	21	the	the	DET
bibechana-68838	32	22	gene	gene	NOUN
bibechana-68838	32	23	bodies	body	NOUN
bibechana-68838	32	24	[	[	X
bibechana-68838	32	25	15,20	15,20	NUM
bibechana-68838	32	26	]	]	PUNCT
bibechana-68838	32	27	.	.	PUNCT
bibechana-68838	33	1	it	it	PRON
bibechana-68838	33	2	regulates	regulate	VERB
bibechana-68838	33	3	gene	gene	NOUN
bibechana-68838	33	4	expression	expression	NOUN
bibechana-68838	33	5	both	both	CCONJ
bibechana-68838	33	6	as	as	ADP
bibechana-68838	33	7	a	a	DET
bibechana-68838	33	8	transcription	transcription	NOUN
bibechana-68838	33	9	repressor	repressor	NOUN
bibechana-68838	33	10	[	[	NOUN
bibechana-68838	33	11	21	21	NUM
bibechana-68838	33	12	]	]	PUNCT
bibechana-68838	33	13	as	as	ADV
bibechana-68838	33	14	well	well	ADV
bibechana-68838	33	15	as	as	ADP
bibechana-68838	33	16	an	an	DET
bibechana-68838	33	17	activator	activator	NOUN
bibechana-68838	33	18	[	[	X
bibechana-68838	33	19	17	17	NUM
bibechana-68838	33	20	]	]	PUNCT
bibechana-68838	33	21	,	,	PUNCT
bibechana-68838	33	22	in	in	ADP
bibechana-68838	33	23	different	different	ADJ
bibechana-68838	33	24	cellular	cellular	ADJ
bibechana-68838	33	25	contexts	contexts	NOUN
bibechana-68838	33	26	.	.	PUNCT
bibechana-68838	34	1	most	most	ADV
bibechana-68838	34	2	importantly	importantly	ADV
bibechana-68838	34	3	,	,	PUNCT
bibechana-68838	34	4	it	it	PRON
bibechana-68838	34	5	acts	act	VERB
bibechana-68838	34	6	as	as	ADP
bibechana-68838	34	7	an	an	DET
bibechana-68838	34	8	enhancer	enhancer	NOUN
bibechana-68838	34	9	blocker	blocker	NOUN
bibechana-68838	34	10	by	by	ADP
bibechana-68838	34	11	blocking	block	VERB
bibechana-68838	34	12	the	the	DET
bibechana-68838	34	13	communication	communication	NOUN
bibechana-68838	34	14	between	between	ADP
bibechana-68838	34	15	an	an	DET
bibechana-68838	34	16	enhancer	enhancer	NOUN
bibechana-68838	34	17	and	and	CCONJ
bibechana-68838	34	18	target	target	NOUN
bibechana-68838	34	19	gene	gene	NOUN
bibechana-68838	34	20	promoter	promoter	NOUN
bibechana-68838	34	21	and	and	CCONJ
bibechana-68838	34	22	hence	hence	ADV
bibechana-68838	34	23	preventing	prevent	VERB
bibechana-68838	34	24	transcriptional	transcriptional	ADJ
bibechana-68838	34	25	activation	activation	NOUN
bibechana-68838	34	26	[	[	X
bibechana-68838	34	27	22,23	22,23	NOUN
bibechana-68838	34	28	]	]	PUNCT
bibechana-68838	34	29	.	.	PUNCT
bibechana-68838	35	1	ctcf	ctcf	PROPN
bibechana-68838	35	2	is	be	AUX
bibechana-68838	35	3	an	an	DET
bibechana-68838	35	4	architectural	architectural	ADJ
bibechana-68838	35	5	protein	protein	NOUN
bibechana-68838	35	6	that	that	PRON
bibechana-68838	35	7	plays	play	VERB
bibechana-68838	35	8	a	a	DET
bibechana-68838	35	9	crucial	crucial	ADJ
bibechana-68838	35	10	role	role	NOUN
bibechana-68838	35	11	in	in	ADP
bibechana-68838	35	12	global	global	ADJ
bibechana-68838	35	13	chromatin	chromatin	NOUN
bibechana-68838	35	14	organization	organization	NOUN
bibechana-68838	35	15	and	and	CCONJ
bibechana-68838	35	16	remodeling	remodeling	NOUN
bibechana-68838	35	17	via	via	ADP
bibechana-68838	35	18	its	its	PRON
bibechana-68838	35	19	interaction	interaction	NOUN
bibechana-68838	35	20	with	with	ADP
bibechana-68838	35	21	several	several	ADJ
bibechana-68838	35	22	protein	protein	NOUN
bibechana-68838	35	23	partners	partner	NOUN
bibechana-68838	35	24	[	[	X
bibechana-68838	35	25	14	14	NUM
bibechana-68838	35	26	]	]	PUNCT
bibechana-68838	35	27	.	.	PUNCT
bibechana-68838	36	1	in	in	ADP
bibechana-68838	36	2	addition	addition	NOUN
bibechana-68838	36	3	,	,	PUNCT
bibechana-68838	36	4	it	it	PRON
bibechana-68838	36	5	also	also	ADV
bibechana-68838	36	6	participates	participate	VERB
bibechana-68838	36	7	in	in	ADP
bibechana-68838	36	8	genomic	genomic	ADJ
bibechana-68838	36	9	imprinting	imprinting	NOUN
bibechana-68838	36	10	,	,	PUNCT
bibechana-68838	36	11	gametogenesis	gametogenesis	NOUN
bibechana-68838	36	12	,	,	PUNCT
bibechana-68838	36	13	and	and	CCONJ
bibechana-68838	36	14	the	the	DET
bibechana-68838	36	15	early	early	ADJ
bibechana-68838	36	16	stages	stage	NOUN
bibechana-68838	36	17	of	of	ADP
bibechana-68838	36	18	mammalian	mammalian	ADJ
bibechana-68838	36	19	development.̧	development.̧	NOUN
bibechana-68838	36	20	becaiter18use	becaiter18use	NOUN
bibechana-68838	36	21	of	of	ADP
bibechana-68838	36	22	its	its	PRON
bibechana-68838	36	23	methylation	methylation	NOUN
bibechana-68838	36	24	-	-	PUNCT
bibechana-68838	36	25	sensitive	sensitive	ADJ
bibechana-68838	36	26	binding	bind	VERB
bibechana-68838	36	27	with	with	ADP
bibechana-68838	36	28	dna	dna	NOUN
bibechana-68838	36	29	and	and	CCONJ
bibechana-68838	36	30	transcription	transcription	NOUN
bibechana-68838	36	31	insulation	insulation	NOUN
bibechana-68838	36	32	activity	activity	NOUN
bibechana-68838	36	33	,	,	PUNCT
bibechana-68838	36	34	ctcf	ctcf	PROPN
bibechana-68838	36	35	allows	allow	VERB
bibechana-68838	36	36	the	the	DET
bibechana-68838	36	37	accurate	accurate	ADJ
bibechana-68838	36	38	expression	expression	NOUN
bibechana-68838	36	39	of	of	ADP
bibechana-68838	36	40	the	the	DET
bibechana-68838	36	41	imprinted	imprint	VERB
bibechana-68838	36	42	genes	gene	NOUN
bibechana-68838	36	43	in	in	ADP
bibechana-68838	36	44	the	the	DET
bibechana-68838	36	45	h19	h19	PROPN
bibechana-68838	36	46	–	–	PUNCT
bibechana-68838	36	47	igf2	igf2	PROPN
bibechana-68838	36	48	locus	locus	NOUN
bibechana-68838	37	1	[	[	X
bibechana-68838	37	2	23,24	23,24	NOUN
bibechana-68838	37	3	]	]	PUNCT
bibechana-68838	37	4	.	.	PUNCT
bibechana-68838	38	1	kaiso	kaiso	NOUN
bibechana-68838	38	2	interacts	interact	VERB
bibechana-68838	38	3	with	with	ADP
bibechana-68838	38	4	ctcf	ctcf	ADJ
bibechana-68838	38	5	protein	protein	NOUN
bibechana-68838	38	6	via	via	ADP
bibechana-68838	38	7	the	the	DET
bibechana-68838	38	8	btb	btb	NOUN
bibechana-68838	38	9	/	/	SYM
bibechana-68838	38	10	poz	poz	PROPN
bibechana-68838	38	11	domain	domain	NOUN
bibechana-68838	38	12	and	and	CCONJ
bibechana-68838	38	13	negatively	negatively	ADV
bibechana-68838	38	14	regulates	regulate	VERB
bibechana-68838	38	15	its	its	PRON
bibechana-68838	38	16	enhancer	enhancer	NOUN
bibechana-68838	38	17	blocker	blocker	NOUN
bibechana-68838	38	18	function	function	NOUN
bibechana-68838	39	1	[	[	X
bibechana-68838	39	2	25	25	NUM
bibechana-68838	39	3	]	]	PUNCT
bibechana-68838	39	4	.	.	PUNCT
bibechana-68838	40	1	interaction	interaction	NOUN
bibechana-68838	40	2	between	between	ADP
bibechana-68838	40	3	kaiso	kaiso	NOUN
bibechana-68838	40	4	and	and	CCONJ
bibechana-68838	40	5	ctcf	ctcf	NOUN
bibechana-68838	40	6	is	be	AUX
bibechana-68838	40	7	physiologically	physiologically	ADV
bibechana-68838	40	8	significant	significant	ADJ
bibechana-68838	40	9	because	because	SCONJ
bibechana-68838	40	10	both	both	DET
bibechana-68838	40	11	proteins	protein	NOUN
bibechana-68838	40	12	are	be	AUX
bibechana-68838	40	13	observed	observe	VERB
bibechana-68838	40	14	to	to	PART
bibechana-68838	40	15	be	be	AUX
bibechana-68838	40	16	co	co	VERB
bibechana-68838	40	17	-	-	VERB
bibechana-68838	40	18	expressed	express	VERB
bibechana-68838	40	19	in	in	ADP
bibechana-68838	40	20	many	many	ADJ
bibechana-68838	40	21	cells	cell	NOUN
bibechana-68838	40	22	.	.	PUNCT
bibechana-68838	41	1	both	both	DET
bibechana-68838	41	2	kaiso	kaiso	NOUN
bibechana-68838	41	3	and	and	CCONJ
bibechana-68838	41	4	ctcf	ctcf	NOUN
bibechana-68838	41	5	are	be	AUX
bibechana-68838	41	6	ubiquitously	ubiquitously	ADV
bibechana-68838	41	7	expressed	express	VERB
bibechana-68838	41	8	proteins	protein	NOUN
bibechana-68838	41	9	that	that	PRON
bibechana-68838	41	10	are	be	AUX
bibechana-68838	41	11	mainly	mainly	ADV
bibechana-68838	41	12	present	present	ADJ
bibechana-68838	41	13	in	in	ADP
bibechana-68838	41	14	the	the	DET
bibechana-68838	41	15	nucleus	nucleus	NOUN
bibechana-68838	42	1	[	[	X
bibechana-68838	42	2	3	3	NUM
bibechana-68838	42	3	,	,	PUNCT
bibechana-68838	42	4	26	26	NUM
bibechana-68838	42	5	]	]	PUNCT
bibechana-68838	42	6	.	.	PUNCT
bibechana-68838	43	1	the	the	DET
bibechana-68838	43	2	kaiso	kaiso	NOUN
bibechana-68838	43	3	consensus	consensus	NOUN
bibechana-68838	43	4	-	-	PUNCT
bibechana-68838	43	5	sequence	sequence	NOUN
bibechana-68838	43	6	kbs	kbs	PROPN
bibechana-68838	43	7	is	be	AUX
bibechana-68838	43	8	positioned	position	VERB
bibechana-68838	43	9	close	close	ADV
bibechana-68838	43	10	to	to	ADP
bibechana-68838	43	11	the	the	DET
bibechana-68838	43	12	ctcf	ctcf	ADJ
bibechana-68838	43	13	binding	bind	VERB
bibechana-68838	43	14	site	site	NOUN
bibechana-68838	43	15	on	on	ADP
bibechana-68838	43	16	the	the	DET
bibechana-68838	43	17	human	human	ADJ
bibechana-68838	43	18	5	5	NUM
bibechana-68838	43	19	’	'	PUNCT
bibechana-68838	43	20	-hs5	-hs5	PUNCT
bibechana-68838	43	21	insulator	insulator	NOUN
bibechana-68838	43	22	at	at	ADP
bibechana-68838	43	23	the	the	DET
bibechana-68838	43	24	-globin	-globin	PROPN
bibechana-68838	43	25	gene	gene	NOUN
bibechana-68838	43	26	cluster	cluster	NOUN
bibechana-68838	43	27	.	.	PUNCT
bibechana-68838	44	1	the	the	DET
bibechana-68838	44	2	close	close	ADJ
bibechana-68838	44	3	positioning	positioning	NOUN
bibechana-68838	44	4	of	of	ADP
bibechana-68838	44	5	the	the	DET
bibechana-68838	44	6	kbs	kbs	PROPN
bibechana-68838	44	7	sequence	sequence	NOUN
bibechana-68838	44	8	significantly	significantly	ADV
bibechana-68838	44	9	reduces	reduce	VERB
bibechana-68838	44	10	the	the	DET
bibechana-68838	44	11	enhancer	enhancer	NOUN
bibechana-68838	44	12	-	-	PUNCT
bibechana-68838	44	13	blocking	blocking	NOUN
bibechana-68838	44	14	of	of	ADP
bibechana-68838	44	15	the	the	DET
bibechana-68838	44	16	globin	globin	NOUN
bibechana-68838	44	17	insulator	insulator	NOUN
bibechana-68838	44	18	[	[	X
bibechana-68838	44	19	25	25	NUM
bibechana-68838	44	20	]	]	PUNCT
bibechana-68838	44	21	.	.	PUNCT
bibechana-68838	45	1	in	in	ADP
bibechana-68838	45	2	addition	addition	NOUN
bibechana-68838	45	3	,	,	PUNCT
bibechana-68838	45	4	the	the	DET
bibechana-68838	45	5	kaiso	kaiso	NOUN
bibechana-68838	45	6	-	-	PUNCT
bibechana-68838	45	7	ctcf	ctcf	NOUN
bibechana-68838	45	8	interaction	interaction	NOUN
bibechana-68838	45	9	is	be	AUX
bibechana-68838	45	10	highly	highly	ADV
bibechana-68838	45	11	specific	specific	ADJ
bibechana-68838	45	12	,	,	PUNCT
bibechana-68838	45	13	as	as	SCONJ
bibechana-68838	45	14	ctcf	ctcf	NOUN
bibechana-68838	45	15	does	do	AUX
bibechana-68838	45	16	not	not	PART
bibechana-68838	45	17	interact	interact	VERB
bibechana-68838	45	18	with	with	ADP
bibechana-68838	45	19	other	other	ADJ
bibechana-68838	45	20	poz	poz	PROPN
bibechana-68838	45	21	domain	domain	NOUN
bibechana-68838	45	22	-	-	PUNCT
bibechana-68838	45	23	containing	contain	VERB
bibechana-68838	45	24	proteins	protein	NOUN
bibechana-68838	45	25	such	such	ADJ
bibechana-68838	45	26	as	as	ADP
bibechana-68838	45	27	bcl-6	bcl-6	PUNCT
bibechana-68838	45	28	,	,	PUNCT
bibechana-68838	45	29	plzf	plzf	NOUN
bibechana-68838	45	30	,	,	PUNCT
bibechana-68838	45	31	and	and	CCONJ
bibechana-68838	45	32	hic-1	hic-1	VERB
bibechana-68838	45	33	[	[	X
bibechana-68838	45	34	25	25	NUM
bibechana-68838	45	35	]	]	PUNCT
bibechana-68838	45	36	.	.	PUNCT
bibechana-68838	46	1	the	the	DET
bibechana-68838	46	2	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	46	3	interaction	interaction	NOUN
bibechana-68838	46	4	inhibits	inhibit	VERB
bibechana-68838	46	5	ctcf	ctcf	PROPN
bibechana-68838	46	6	binding	bind	VERB
bibechana-68838	46	7	to	to	ADP
bibechana-68838	46	8	its	its	PRON
bibechana-68838	46	9	target	target	NOUN
bibechana-68838	46	10	sites	site	NOUN
bibechana-68838	46	11	,	,	PUNCT
bibechana-68838	46	12	and	and	CCONJ
bibechana-68838	46	13	it	it	PRON
bibechana-68838	46	14	might	might	AUX
bibechana-68838	46	15	be	be	AUX
bibechana-68838	46	16	used	use	VERB
bibechana-68838	46	17	to	to	PART
bibechana-68838	46	18	down	down	ADV
bibechana-68838	46	19	-	-	PUNCT
bibechana-68838	46	20	regulate	regulate	VERB
bibechana-68838	46	21	the	the	DET
bibechana-68838	46	22	undesirable	undesirable	ADJ
bibechana-68838	46	23	enhancer	enhancer	NOUN
bibechana-68838	46	24	-	-	PUNCT
bibechana-68838	46	25	blocking	block	VERB
bibechana-68838	46	26	activity	activity	NOUN
bibechana-68838	46	27	in	in	ADP
bibechana-68838	46	28	specific	specific	ADJ
bibechana-68838	46	29	cell	cell	NOUN
bibechana-68838	46	30	types	type	NOUN
bibechana-68838	46	31	.	.	PUNCT
bibechana-68838	47	1	similarly	similarly	ADV
bibechana-68838	47	2	,	,	PUNCT
bibechana-68838	47	3	since	since	SCONJ
bibechana-68838	47	4	the	the	DET
bibechana-68838	47	5	poz	poz	PROPN
bibechana-68838	47	6	domain	domain	NOUN
bibechana-68838	47	7	of	of	ADP
bibechana-68838	47	8	kaiso	kaiso	NOUN
bibechana-68838	47	9	is	be	AUX
bibechana-68838	47	10	involved	involve	VERB
bibechana-68838	47	11	in	in	ADP
bibechana-68838	47	12	recruiting	recruit	VERB
bibechana-68838	47	13	the	the	DET
bibechana-68838	47	14	nuclear	nuclear	ADJ
bibechana-68838	47	15	corepressor	corepressor	NOUN
bibechana-68838	47	16	complex	complex	NOUN
bibechana-68838	47	17	to	to	PART
bibechana-68838	47	18	mediate	mediate	VERB
bibechana-68838	47	19	transcription	transcription	NOUN
bibechana-68838	47	20	repression	repression	NOUN
bibechana-68838	47	21	,	,	PUNCT
bibechana-68838	47	22	this	this	DET
bibechana-68838	47	23	interaction	interaction	NOUN
bibechana-68838	47	24	might	might	AUX
bibechana-68838	47	25	regulate	regulate	VERB
bibechana-68838	47	26	the	the	DET
bibechana-68838	47	27	transcriptional	transcriptional	ADJ
bibechana-68838	47	28	activity	activity	NOUN
bibechana-68838	47	29	of	of	ADP
bibechana-68838	47	30	kaiso	kaiso	NOUN
bibechana-68838	47	31	.	.	PUNCT
bibechana-68838	48	1	in	in	ADP
bibechana-68838	48	2	addition	addition	NOUN
bibechana-68838	48	3	,	,	PUNCT
bibechana-68838	48	4	the	the	DET
bibechana-68838	48	5	poz	poz	PROPN
bibechana-68838	48	6	domain	domain	NOUN
bibechana-68838	48	7	is	be	AUX
bibechana-68838	48	8	involved	involve	VERB
bibechana-68838	48	9	in	in	ADP
bibechana-68838	48	10	the	the	DET
bibechana-68838	48	11	homodimerization	homodimerization	NOUN
bibechana-68838	48	12	of	of	ADP
bibechana-68838	48	13	kaiso	kaiso	NOUN
bibechana-68838	48	14	(	(	PUNCT
bibechana-68838	48	15	daniel	daniel	PROPN
bibechana-68838	48	16	et	et	PROPN
bibechana-68838	48	17	al	al	PROPN
bibechana-68838	48	18	.	.	PROPN
bibechana-68838	48	19	,	,	PUNCT
bibechana-68838	48	20	1999	1999	NUM
bibechana-68838	48	21	)	)	PUNCT
bibechana-68838	48	22	.	.	PUNCT
bibechana-68838	49	1	interactions	interaction	NOUN
bibechana-68838	49	2	of	of	ADP
bibechana-68838	49	3	kaiso	kaiso	NOUN
bibechana-68838	49	4	with	with	ADP
bibechana-68838	49	5	ctcf	ctcf	NOUN
bibechana-68838	49	6	could	could	AUX
bibechana-68838	49	7	possibly	possibly	ADV
bibechana-68838	49	8	affect	affect	VERB
bibechana-68838	49	9	its	its	PRON
bibechana-68838	49	10	homodimerization	homodimerization	NOUN
bibechana-68838	49	11	and	and	CCONJ
bibechana-68838	49	12	,	,	PUNCT
bibechana-68838	49	13	thereby	thereby	ADV
bibechana-68838	49	14	,	,	PUNCT
bibechana-68838	49	15	other	other	ADJ
bibechana-68838	49	16	kaiso	kaiso	NOUN
bibechana-68838	49	17	-	-	PUNCT
bibechana-68838	49	18	mediated	mediate	VERB
bibechana-68838	49	19	activity	activity	NOUN
bibechana-68838	49	20	[	[	X
bibechana-68838	49	21	25	25	NUM
bibechana-68838	49	22	]	]	PUNCT
bibechana-68838	49	23	.	.	PUNCT
bibechana-68838	50	1	defossez	defossez	VERB
bibechana-68838	50	2	et	et	PROPN
bibechana-68838	50	3	al	al	PROPN
bibechana-68838	50	4	.	.	PROPN
bibechana-68838	51	1	(	(	PUNCT
bibechana-68838	51	2	2005	2005	NUM
bibechana-68838	51	3	)	)	PUNCT
bibechana-68838	51	4	have	have	AUX
bibechana-68838	51	5	shown	show	VERB
bibechana-68838	51	6	that	that	SCONJ
bibechana-68838	51	7	the	the	DET
bibechana-68838	51	8	cterminal	cterminal	ADJ
bibechana-68838	51	9	region	region	NOUN
bibechana-68838	51	10	of	of	ADP
bibechana-68838	51	11	ctcf	ctcf	PROPN
bibechana-68838	51	12	binds	bind	VERB
bibechana-68838	51	13	with	with	ADP
bibechana-68838	51	14	kaiso	kaiso	NOUN
bibechana-68838	51	15	.	.	PUNCT
bibechana-68838	52	1	the	the	DET
bibechana-68838	52	2	amino	amino	NOUN
bibechana-68838	52	3	-	-	PUNCT
bibechana-68838	52	4	acid	acid	NOUN
bibechana-68838	52	5	residues	residue	NOUN
bibechana-68838	52	6	640	640	NUM
bibechana-68838	52	7	-	-	SYM
bibechana-68838	52	8	724	724	NUM
bibechana-68838	52	9	in	in	ADP
bibechana-68838	52	10	ctcf	ctcf	NOUN
bibechana-68838	52	11	are	be	AUX
bibechana-68838	52	12	reported	report	VERB
bibechana-68838	52	13	to	to	PART
bibechana-68838	52	14	be	be	AUX
bibechana-68838	52	15	involved	involve	VERB
bibechana-68838	52	16	in	in	ADP
bibechana-68838	52	17	the	the	DET
bibechana-68838	52	18	interactions	interaction	NOUN
bibechana-68838	52	19	with	with	ADP
bibechana-68838	52	20	the	the	DET
bibechana-68838	52	21	poz	poz	PROPN
bibechana-68838	52	22	domain	domain	NOUN
bibechana-68838	52	23	of	of	ADP
bibechana-68838	52	24	kaiso	kaiso	NOUN
bibechana-68838	52	25	.	.	PUNCT
bibechana-68838	53	1	however	however	ADV
bibechana-68838	53	2	,	,	PUNCT
bibechana-68838	53	3	no	no	DET
bibechana-68838	53	4	experimentally	experimentally	ADV
bibechana-68838	53	5	solved	solve	VERB
bibechana-68838	53	6	structure	structure	NOUN
bibechana-68838	53	7	is	be	AUX
bibechana-68838	53	8	available	available	ADJ
bibechana-68838	53	9	for	for	ADP
bibechana-68838	53	10	this	this	DET
bibechana-68838	53	11	complex	complex	NOUN
bibechana-68838	53	12	because	because	SCONJ
bibechana-68838	53	13	of	of	ADP
bibechana-68838	53	14	the	the	DET
bibechana-68838	53	15	largely	largely	ADV
bibechana-68838	53	16	unstructured	unstructured	ADJ
bibechana-68838	53	17	and	and	CCONJ
bibechana-68838	53	18	flexible	flexible	ADJ
bibechana-68838	53	19	nature	nature	NOUN
bibechana-68838	53	20	of	of	ADP
bibechana-68838	53	21	this	this	DET
bibechana-68838	53	22	region	region	NOUN
bibechana-68838	53	23	.	.	PUNCT
bibechana-68838	54	1	in	in	ADP
bibechana-68838	54	2	addition	addition	NOUN
bibechana-68838	54	3	,	,	PUNCT
bibechana-68838	54	4	the	the	DET
bibechana-68838	54	5	specific	specific	ADJ
bibechana-68838	54	6	binding	bind	VERB
bibechana-68838	54	7	region	region	NOUN
bibechana-68838	54	8	and	and	CCONJ
bibechana-68838	54	9	key	key	ADJ
bibechana-68838	54	10	residues	residue	NOUN
bibechana-68838	54	11	involved	involve	VERB
bibechana-68838	54	12	in	in	ADP
bibechana-68838	54	13	the	the	DET
bibechana-68838	54	14	interactions	interaction	NOUN
bibechana-68838	54	15	are	be	AUX
bibechana-68838	54	16	not	not	PART
bibechana-68838	54	17	identified	identify	VERB
bibechana-68838	54	18	.	.	PUNCT
bibechana-68838	55	1	identification	identification	NOUN
bibechana-68838	55	2	of	of	ADP
bibechana-68838	55	3	key	key	ADJ
bibechana-68838	55	4	residues	residue	NOUN
bibechana-68838	55	5	involved	involve	VERB
bibechana-68838	55	6	in	in	ADP
bibechana-68838	55	7	the	the	DET
bibechana-68838	55	8	interactions	interaction	NOUN
bibechana-68838	55	9	of	of	ADP
bibechana-68838	55	10	the	the	DET
bibechana-68838	55	11	protein	protein	NOUN
bibechana-68838	55	12	with	with	ADP
bibechana-68838	55	13	its	its	PRON
bibechana-68838	55	14	binding	bind	VERB
bibechana-68838	55	15	partner	partner	NOUN
bibechana-68838	55	16	is	be	AUX
bibechana-68838	55	17	essential	essential	ADJ
bibechana-68838	55	18	to	to	PART
bibechana-68838	55	19	understand	understand	VERB
bibechana-68838	55	20	the	the	DET
bibechana-68838	55	21	structural	structural	ADJ
bibechana-68838	55	22	features	feature	NOUN
bibechana-68838	55	23	of	of	ADP
bibechana-68838	55	24	the	the	DET
bibechana-68838	55	25	complex	complex	NOUN
bibechana-68838	55	26	and	and	CCONJ
bibechana-68838	55	27	their	their	PRON
bibechana-68838	55	28	binding	bind	VERB
bibechana-68838	55	29	affinity	affinity	NOUN
bibechana-68838	55	30	.	.	PUNCT
bibechana-68838	56	1	in	in	ADP
bibechana-68838	56	2	this	this	DET
bibechana-68838	56	3	work	work	NOUN
bibechana-68838	56	4	,	,	PUNCT
bibechana-68838	56	5	we	we	PRON
bibechana-68838	56	6	used	use	VERB
bibechana-68838	56	7	the	the	DET
bibechana-68838	56	8	neural	neural	ADJ
bibechana-68838	56	9	network	network	NOUN
bibechana-68838	56	10	-	-	PUNCT
bibechana-68838	56	11	based	base	VERB
bibechana-68838	56	12	modeling	modeling	NOUN
bibechana-68838	56	13	method	method	NOUN
bibechana-68838	56	14	alphafold2	alphafold2	ADJ
bibechana-68838	56	15	to	to	PART
bibechana-68838	56	16	predict	predict	VERB
bibechana-68838	56	17	the	the	DET
bibechana-68838	56	18	complex	complex	NOUN
bibechana-68838	56	19	between	between	ADP
bibechana-68838	56	20	ctcf	ctcf	NOUN
bibechana-68838	56	21	and	and	CCONJ
bibechana-68838	56	22	kaiso	kaiso	NOUN
bibechana-68838	56	23	.	.	PUNCT
bibechana-68838	57	1	furthermore	furthermore	ADV
bibechana-68838	57	2	,	,	PUNCT
bibechana-68838	57	3	we	we	PRON
bibechana-68838	57	4	optimized	optimize	VERB
bibechana-68838	57	5	this	this	DET
bibechana-68838	57	6	interaction	interaction	NOUN
bibechana-68838	57	7	using	use	VERB
bibechana-68838	57	8	md	md	PROPN
bibechana-68838	57	9	simulation	simulation	NOUN
bibechana-68838	57	10	and	and	CCONJ
bibechana-68838	57	11	assessed	assess	VERB
bibechana-68838	57	12	the	the	DET
bibechana-68838	57	13	structural	structural	ADJ
bibechana-68838	57	14	stability	stability	NOUN
bibechana-68838	57	15	of	of	ADP
bibechana-68838	57	16	the	the	DET
bibechana-68838	57	17	predicted	predict	VERB
bibechana-68838	57	18	complex	complex	NOUN
bibechana-68838	57	19	.	.	PUNCT
bibechana-68838	58	1	we	we	PRON
bibechana-68838	58	2	predicted	predict	VERB
bibechana-68838	58	3	the	the	DET
bibechana-68838	58	4	key	key	ADJ
bibechana-68838	58	5	residues	residue	NOUN
bibechana-68838	58	6	involved	involve	VERB
bibechana-68838	58	7	in	in	ADP
bibechana-68838	58	8	the	the	DET
bibechana-68838	58	9	formation	formation	NOUN
bibechana-68838	58	10	of	of	ADP
bibechana-68838	58	11	the	the	DET
bibechana-68838	58	12	complex	complex	NOUN
bibechana-68838	58	13	.	.	PUNCT
bibechana-68838	59	1	in	in	ADP
bibechana-68838	59	2	addition	addition	NOUN
bibechana-68838	59	3	,	,	PUNCT
bibechana-68838	59	4	we	we	PRON
bibechana-68838	59	5	investigated	investigate	VERB
bibechana-68838	59	6	the	the	DET
bibechana-68838	59	7	dynamics	dynamic	NOUN
bibechana-68838	59	8	of	of	ADP
bibechana-68838	59	9	the	the	DET
bibechana-68838	59	10	interactions	interaction	NOUN
bibechana-68838	59	11	that	that	PRON
bibechana-68838	59	12	are	be	AUX
bibechana-68838	59	13	responsible	responsible	ADJ
bibechana-68838	59	14	for	for	ADP
bibechana-68838	59	15	the	the	DET
bibechana-68838	59	16	binding	binding	NOUN
bibechana-68838	59	17	of	of	ADP
bibechana-68838	59	18	the	the	DET
bibechana-68838	59	19	poz	poz	PROPN
bibechana-68838	59	20	domain	domain	NOUN
bibechana-68838	59	21	of	of	ADP
bibechana-68838	59	22	the	the	DET
bibechana-68838	59	23	kaiso	kaiso	NOUN
bibechana-68838	59	24	with	with	ADP
bibechana-68838	59	25	ctcf	ctcf	PROPN
bibechana-68838	59	26	.	.	PUNCT
bibechana-68838	60	1	our	our	PRON
bibechana-68838	60	2	results	result	NOUN
bibechana-68838	60	3	show	show	VERB
bibechana-68838	60	4	that	that	SCONJ
bibechana-68838	60	5	the	the	DET
bibechana-68838	60	6	-sheet	-sheet	NOUN
bibechana-68838	60	7	consisting	consist	VERB
bibechana-68838	60	8	of	of	ADP
bibechana-68838	60	9	two	two	NUM
bibechana-68838	60	10	parallel	parallel	ADJ
bibechana-68838	60	11	-strand	-strand	NOUN
bibechana-68838	60	12	interacts	interact	VERB
bibechana-68838	60	13	with	with	ADP
bibechana-68838	60	14	the	the	DET
bibechana-68838	60	15	c	c	NOUN
bibechana-68838	60	16	-	-	PUNCT
bibechana-68838	60	17	terminal	terminal	ADJ
bibechana-68838	60	18	end	end	NOUN
bibechana-68838	60	19	of	of	ADP
bibechana-68838	60	20	the	the	DET
bibechana-68838	60	21	poz	poz	PROPN
bibechana-68838	60	22	domain	domain	NOUN
bibechana-68838	60	23	.	.	PUNCT
bibechana-68838	61	1	as	as	SCONJ
bibechana-68838	61	2	the	the	DET
bibechana-68838	61	3	poz	poz	PROPN
bibechana-68838	61	4	domain	domain	NOUN
bibechana-68838	61	5	in	in	ADP
bibechana-68838	61	6	kaiso	kaiso	NOUN
bibechana-68838	61	7	is	be	AUX
bibechana-68838	61	8	highly	highly	ADV
bibechana-68838	61	9	hydrophobic	hydrophobic	ADJ
bibechana-68838	61	10	and	and	CCONJ
bibechana-68838	61	11	the	the	DET
bibechana-68838	61	12	-sheet	-sheet	NOUN
bibechana-68838	61	13	in	in	ADP
bibechana-68838	61	14	ctcf	ctcf	PROPN
bibechana-68838	61	15	contains	contain	VERB
bibechana-68838	61	16	several	several	ADJ
bibechana-68838	61	17	hydrophobic	hydrophobic	NOUN
bibechana-68838	61	18	residues	residue	NOUN
bibechana-68838	61	19	at	at	ADP
bibechana-68838	61	20	the	the	DET
bibechana-68838	61	21	binding	bind	VERB
bibechana-68838	61	22	site	site	NOUN
bibechana-68838	61	23	,	,	PUNCT
bibechana-68838	61	24	hydrophobic	hydrophobic	NOUN
bibechana-68838	61	25	interactions	interaction	NOUN
bibechana-68838	61	26	play	play	VERB
bibechana-68838	61	27	a	a	DET
bibechana-68838	61	28	significant	significant	ADJ
bibechana-68838	61	29	role	role	NOUN
bibechana-68838	61	30	in	in	ADP
bibechana-68838	61	31	forming	form	VERB
bibechana-68838	61	32	the	the	DET
bibechana-68838	61	33	kaiso	kaiso	NOUN
bibechana-68838	61	34	-	-	PUNCT
bibechana-68838	61	35	ctcf	ctcf	NOUN
bibechana-68838	61	36	complex	complex	NOUN
bibechana-68838	61	37	.	.	PUNCT
bibechana-68838	62	1	in	in	ADP
bibechana-68838	62	2	addition	addition	NOUN
bibechana-68838	62	3	,	,	PUNCT
bibechana-68838	62	4	several	several	ADJ
bibechana-68838	62	5	hydrogen	hydrogen	NOUN
bibechana-68838	62	6	bonds	bond	NOUN
bibechana-68838	62	7	,	,	PUNCT
bibechana-68838	62	8	electrostatic	electrostatic	ADJ
bibechana-68838	62	9	,	,	PUNCT
bibechana-68838	62	10	and	and	CCONJ
bibechana-68838	62	11	van	van	PROPN
bibechana-68838	62	12	der	der	NOUN
bibechana-68838	62	13	waals	waal	NOUN
bibechana-68838	62	14	interactions	interaction	NOUN
bibechana-68838	62	15	stabilize	stabilize	VERB
bibechana-68838	62	16	the	the	DET
bibechana-68838	62	17	complex	complex	NOUN
bibechana-68838	62	18	.	.	PUNCT
bibechana-68838	63	1	the	the	DET
bibechana-68838	63	2	considerable	considerable	ADJ
bibechana-68838	63	3	value	value	NOUN
bibechana-68838	63	4	of	of	ADP
bibechana-68838	63	5	binding	bind	VERB
bibechana-68838	63	6	free	free	ADJ
bibechana-68838	63	7	energy	energy	NOUN
bibechana-68838	63	8	suggests	suggest	VERB
bibechana-68838	63	9	that	that	SCONJ
bibechana-68838	63	10	the	the	DET
bibechana-68838	63	11	predicted	predict	VERB
bibechana-68838	63	12	complex	complex	NOUN
bibechana-68838	63	13	is	be	AUX
bibechana-68838	63	14	stable	stable	ADJ
bibechana-68838	63	15	.	.	PUNCT
bibechana-68838	64	1	2	2	NUM
bibechana-68838	64	2	materials	material	NOUN
bibechana-68838	64	3	and	and	CCONJ
bibechana-68838	64	4	methods	method	NOUN
bibechana-68838	64	5	2.1	2.1	NUM
bibechana-68838	64	6	protein	protein	NOUN
bibechana-68838	64	7	structures	structure	NOUN
bibechana-68838	64	8	and	and	CCONJ
bibechana-68838	64	9	molecular	molecular	ADJ
bibechana-68838	64	10	modeling	model	VERB
bibechana-68838	64	11	the	the	DET
bibechana-68838	64	12	input	input	NOUN
bibechana-68838	64	13	sequences	sequence	NOUN
bibechana-68838	64	14	for	for	ADP
bibechana-68838	64	15	the	the	DET
bibechana-68838	64	16	kaiso	kaiso	NOUN
bibechana-68838	64	17	and	and	CCONJ
bibechana-68838	64	18	ctcf	ctcf	ADJ
bibechana-68838	64	19	proteins	protein	NOUN
bibechana-68838	64	20	were	be	AUX
bibechana-68838	64	21	taken	take	VERB
bibechana-68838	64	22	from	from	ADP
bibechana-68838	64	23	the	the	DET
bibechana-68838	64	24	uniport	uniport	NOUN
bibechana-68838	64	25	knowledgebase	knowledgebase	PROPN
bibechana-68838	64	26	(	(	PUNCT
bibechana-68838	64	27	uniprotkb	uniprotkb	NOUN
bibechana-68838	64	28	)	)	PUNCT
bibechana-68838	65	1	[	[	X
bibechana-68838	65	2	27	27	NUM
bibechana-68838	65	3	]	]	PUNCT
bibechana-68838	65	4	.	.	PUNCT
bibechana-68838	66	1	the	the	DET
bibechana-68838	66	2	complete	complete	ADJ
bibechana-68838	66	3	structure	structure	NOUN
bibechana-68838	66	4	of	of	ADP
bibechana-68838	66	5	the	the	DET
bibechana-68838	66	6	bidhya	bidhya	NOUN
bibechana-68838	66	7	thapa	thapa	PROPN
bibechana-68838	66	8	and	and	CCONJ
bibechana-68838	66	9	narayan	narayan	PROPN
bibechana-68838	66	10	prasad	prasad	PROPN
bibechana-68838	66	11	adhikari/	adhikari/	NUM
bibechana-68838	66	12	bibechana	bibechana	NOUN
bibechana-68838	66	13	21	21	NUM
bibechana-68838	66	14	(	(	PUNCT
bibechana-68838	66	15	2024	2024	NUM
bibechana-68838	66	16	)	)	PUNCT
bibechana-68838	66	17	290	290	NUM
bibechana-68838	66	18	-	-	SYM
bibechana-68838	66	19	299	299	NUM
bibechana-68838	66	20	292	292	NUM
bibechana-68838	66	21	kaiso	kaiso	NOUN
bibechana-68838	66	22	and	and	CCONJ
bibechana-68838	66	23	ctcf	ctcf	NOUN
bibechana-68838	66	24	,	,	PUNCT
bibechana-68838	66	25	shown	show	VERB
bibechana-68838	66	26	in	in	ADP
bibechana-68838	66	27	figures	figure	NOUN
bibechana-68838	66	28	1a	1a	PROPN
bibechana-68838	66	29	and	and	CCONJ
bibechana-68838	66	30	1b	1b	NUM
bibechana-68838	66	31	,	,	PUNCT
bibechana-68838	66	32	were	be	AUX
bibechana-68838	66	33	modeled	model	VERB
bibechana-68838	66	34	using	use	VERB
bibechana-68838	66	35	the	the	DET
bibechana-68838	66	36	neural	neural	ADJ
bibechana-68838	66	37	network	network	NOUN
bibechana-68838	66	38	(	(	PUNCT
bibechana-68838	66	39	nn)-based	nn)-based	ADJ
bibechana-68838	66	40	alphafold2	alphafold2	NOUN
bibechana-68838	66	41	implemented	implement	VERB
bibechana-68838	66	42	in	in	ADP
bibechana-68838	66	43	colabfold	colabfold	ADJ
bibechana-68838	67	1	[	[	X
bibechana-68838	67	2	28–30	28–30	PROPN
bibechana-68838	67	3	]	]	PUNCT
bibechana-68838	67	4	.	.	PUNCT
bibechana-68838	68	1	colabfold	colabfold	PROPN
bibechana-68838	68	2	is	be	AUX
bibechana-68838	68	3	an	an	DET
bibechana-68838	68	4	accelerated	accelerated	ADJ
bibechana-68838	68	5	approach	approach	NOUN
bibechana-68838	68	6	to	to	ADP
bibechana-68838	68	7	structure	structure	NOUN
bibechana-68838	68	8	prediction	prediction	NOUN
bibechana-68838	68	9	that	that	PRON
bibechana-68838	68	10	combines	combine	VERB
bibechana-68838	68	11	the	the	DET
bibechana-68838	68	12	fast	fast	ADJ
bibechana-68838	68	13	homology	homology	NOUN
bibechana-68838	68	14	search	search	NOUN
bibechana-68838	68	15	of	of	ADP
bibechana-68838	68	16	optimized	optimize	VERB
bibechana-68838	68	17	multiple	multiple	ADJ
bibechana-68838	68	18	sequence	sequence	NOUN
bibechana-68838	68	19	alignment	alignment	NOUN
bibechana-68838	68	20	(	(	PUNCT
bibechana-68838	68	21	msas	msa	NOUN
bibechana-68838	68	22	)	)	PUNCT
bibechana-68838	68	23	generation	generation	NOUN
bibechana-68838	68	24	by	by	ADP
bibechana-68838	68	25	mmseqs2	mmseqs2	PROPN
bibechana-68838	68	26	(	(	PUNCT
bibechana-68838	68	27	many	many	ADJ
bibechana-68838	68	28	-	-	PUNCT
bibechana-68838	68	29	against	against	ADP
bibechana-68838	68	30	-	-	PUNCT
bibechana-68838	68	31	many	many	ADJ
bibechana-68838	68	32	sequence	sequence	NOUN
bibechana-68838	68	33	searching	search	VERB
bibechana-68838	68	34	)	)	PUNCT
bibechana-68838	69	1	[	[	X
bibechana-68838	69	2	30	30	NUM
bibechana-68838	69	3	]	]	PUNCT
bibechana-68838	69	4	.	.	PUNCT
bibechana-68838	70	1	we	we	PRON
bibechana-68838	70	2	used	use	VERB
bibechana-68838	70	3	colabfold	colabfold	ADJ
bibechana-68838	70	4	v1.5.5	v1.5.5	NOUN
bibechana-68838	70	5	:	:	PUNCT
bibechana-68838	70	6	alphafold2	alphafold2	ADJ
bibechana-68838	70	7	using	use	VERB
bibechana-68838	70	8	mmseqs2	mmseqs2	PROPN
bibechana-68838	70	9	.	.	PUNCT
bibechana-68838	71	1	the	the	DET
bibechana-68838	71	2	c	c	NOUN
bibechana-68838	71	3	-	-	PUNCT
bibechana-68838	71	4	terminal	terminal	ADJ
bibechana-68838	71	5	region	region	NOUN
bibechana-68838	71	6	of	of	ADP
bibechana-68838	71	7	ctcf	ctcf	PROPN
bibechana-68838	71	8	is	be	AUX
bibechana-68838	71	9	reported	report	VERB
bibechana-68838	71	10	to	to	PART
bibechana-68838	71	11	interact	interact	VERB
bibechana-68838	71	12	with	with	ADP
bibechana-68838	71	13	the	the	DET
bibechana-68838	71	14	btb	btb	NOUN
bibechana-68838	71	15	/	/	SYM
bibechana-68838	71	16	poz	poz	PROPN
bibechana-68838	71	17	domain	domain	NOUN
bibechana-68838	71	18	of	of	ADP
bibechana-68838	71	19	kaiso	kaiso	NOUN
bibechana-68838	71	20	[	[	X
bibechana-68838	71	21	25	25	NUM
bibechana-68838	71	22	]	]	PUNCT
bibechana-68838	71	23	.	.	PUNCT
bibechana-68838	72	1	using	use	VERB
bibechana-68838	72	2	this	this	DET
bibechana-68838	72	3	information	information	NOUN
bibechana-68838	72	4	,	,	PUNCT
bibechana-68838	72	5	the	the	DET
bibechana-68838	72	6	amino	amino	NOUN
bibechana-68838	72	7	acids	acid	NOUN
bibechana-68838	72	8	640	640	NUM
bibechana-68838	72	9	-	-	SYM
bibechana-68838	72	10	724	724	NUM
bibechana-68838	72	11	in	in	ADP
bibechana-68838	72	12	the	the	DET
bibechana-68838	72	13	c	c	NOUN
bibechana-68838	72	14	-	-	PUNCT
bibechana-68838	72	15	terminal	terminal	ADJ
bibechana-68838	72	16	domain	domain	NOUN
bibechana-68838	72	17	were	be	AUX
bibechana-68838	72	18	taken	take	VERB
bibechana-68838	72	19	as	as	ADP
bibechana-68838	72	20	input	input	NOUN
bibechana-68838	72	21	sequences	sequence	NOUN
bibechana-68838	72	22	for	for	ADP
bibechana-68838	72	23	ctcf	ctcf	NOUN
bibechana-68838	72	24	.	.	PUNCT
bibechana-68838	73	1	similarly	similarly	ADV
bibechana-68838	73	2	,	,	PUNCT
bibechana-68838	73	3	the	the	DET
bibechana-68838	73	4	residues	residue	NOUN
bibechana-68838	73	5	1	1	NUM
bibechana-68838	73	6	-	-	SYM
bibechana-68838	73	7	120	120	NUM
bibechana-68838	73	8	in	in	ADP
bibechana-68838	73	9	the	the	DET
bibechana-68838	73	10	btb	btb	NOUN
bibechana-68838	73	11	/	/	SYM
bibechana-68838	73	12	poz	poz	PROPN
bibechana-68838	73	13	domain	domain	NOUN
bibechana-68838	73	14	were	be	AUX
bibechana-68838	73	15	taken	take	VERB
bibechana-68838	73	16	as	as	ADP
bibechana-68838	73	17	the	the	DET
bibechana-68838	73	18	input	input	NOUN
bibechana-68838	73	19	sequence	sequence	NOUN
bibechana-68838	73	20	for	for	ADP
bibechana-68838	73	21	kaiso	kaiso	NOUN
bibechana-68838	73	22	.	.	PUNCT
bibechana-68838	74	1	the	the	DET
bibechana-68838	74	2	complex	complex	NOUN
bibechana-68838	74	3	between	between	ADP
bibechana-68838	74	4	kaiso	kaiso	NOUN
bibechana-68838	74	5	and	and	CCONJ
bibechana-68838	74	6	ctcf	ctcf	NOUN
bibechana-68838	74	7	was	be	AUX
bibechana-68838	74	8	modeled	model	VERB
bibechana-68838	74	9	using	use	VERB
bibechana-68838	74	10	the	the	DET
bibechana-68838	74	11	colabfold	colabfold	NOUN
bibechana-68838	74	12	.	.	PUNCT
bibechana-68838	75	1	we	we	PRON
bibechana-68838	75	2	used	use	VERB
bibechana-68838	75	3	the	the	DET
bibechana-68838	75	4	prediction	prediction	NOUN
bibechana-68838	75	5	model	model	NOUN
bibechana-68838	75	6	alphafold2_ptm	alphafold2_ptm	NOUN
bibechana-68838	75	7	for	for	ADP
bibechana-68838	75	8	the	the	DET
bibechana-68838	75	9	monomer	monomer	NOUN
bibechana-68838	75	10	prediction	prediction	NOUN
bibechana-68838	75	11	,	,	PUNCT
bibechana-68838	75	12	whereas	whereas	SCONJ
bibechana-68838	75	13	the	the	DET
bibechana-68838	75	14	kaiso	kaiso	NOUN
bibechana-68838	75	15	-	-	PUNCT
bibechana-68838	75	16	ctcf	ctcf	NOUN
bibechana-68838	75	17	complex	complex	NOUN
bibechana-68838	75	18	was	be	AUX
bibechana-68838	75	19	predicted	predict	VERB
bibechana-68838	75	20	using	use	VERB
bibechana-68838	75	21	the	the	DET
bibechana-68838	75	22	alphafold2_multimer_v3	alphafold2_multimer_v3	NOUN
bibechana-68838	75	23	prediction	prediction	NOUN
bibechana-68838	75	24	model	model	NOUN
bibechana-68838	75	25	.	.	PUNCT
bibechana-68838	76	1	the	the	DET
bibechana-68838	76	2	number	number	NOUN
bibechana-68838	76	3	of	of	ADP
bibechana-68838	76	4	recycles	recycle	NOUN
bibechana-68838	76	5	controls	control	VERB
bibechana-68838	76	6	the	the	DET
bibechana-68838	76	7	number	number	NOUN
bibechana-68838	76	8	of	of	ADP
bibechana-68838	76	9	times	time	NOUN
bibechana-68838	76	10	the	the	DET
bibechana-68838	76	11	prediction	prediction	NOUN
bibechana-68838	76	12	is	be	AUX
bibechana-68838	76	13	repeatedly	repeatedly	ADV
bibechana-68838	76	14	fed	feed	VERB
bibechana-68838	76	15	through	through	ADP
bibechana-68838	76	16	the	the	DET
bibechana-68838	76	17	model	model	NOUN
bibechana-68838	76	18	.	.	PUNCT
bibechana-68838	77	1	for	for	ADP
bibechana-68838	77	2	monomeric	monomeric	ADJ
bibechana-68838	77	3	prediction	prediction	NOUN
bibechana-68838	77	4	,	,	PUNCT
bibechana-68838	77	5	the	the	DET
bibechana-68838	77	6	number	number	NOUN
bibechana-68838	77	7	of	of	ADP
bibechana-68838	77	8	recycles	recycle	NOUN
bibechana-68838	77	9	is	be	AUX
bibechana-68838	77	10	chosen	choose	VERB
bibechana-68838	77	11	to	to	PART
bibechana-68838	77	12	be	be	AUX
bibechana-68838	77	13	3	3	NUM
bibechana-68838	77	14	(	(	PUNCT
bibechana-68838	77	15	num_recycles=3	num_recycles=3	INTJ
bibechana-68838	77	16	)	)	PUNCT
bibechana-68838	77	17	.	.	PUNCT
bibechana-68838	78	1	however	however	ADV
bibechana-68838	78	2	,	,	PUNCT
bibechana-68838	78	3	we	we	PRON
bibechana-68838	78	4	have	have	AUX
bibechana-68838	78	5	used	use	VERB
bibechana-68838	78	6	20	20	NUM
bibechana-68838	78	7	recycles	recycle	NOUN
bibechana-68838	78	8	(	(	PUNCT
bibechana-68838	78	9	num_recycles=20	num_recycles=20	PROPN
bibechana-68838	78	10	)	)	PUNCT
bibechana-68838	78	11	for	for	ADP
bibechana-68838	78	12	complex	complex	ADJ
bibechana-68838	78	13	prediction	prediction	NOUN
bibechana-68838	78	14	using	use	VERB
bibechana-68838	78	15	alphafold2_multimer_v3	alphafold2_multimer_v3	NOUN
bibechana-68838	78	16	.	.	PUNCT
bibechana-68838	79	1	the	the	DET
bibechana-68838	79	2	recyle_early_stop_tolerance	recyle_early_stop_tolerance	NOUN
bibechana-68838	79	3	,	,	PUNCT
bibechana-68838	79	4	which	which	PRON
bibechana-68838	79	5	specifies	specify	VERB
bibechana-68838	79	6	when	when	SCONJ
bibechana-68838	79	7	to	to	PART
bibechana-68838	79	8	stop	stop	VERB
bibechana-68838	79	9	the	the	DET
bibechana-68838	79	10	recycling	recycling	NOUN
bibechana-68838	79	11	,	,	PUNCT
bibechana-68838	79	12	was	be	AUX
bibechana-68838	79	13	chosen	choose	VERB
bibechana-68838	79	14	to	to	PART
bibechana-68838	79	15	be	be	AUX
bibechana-68838	79	16	0.0	0.0	NUM
bibechana-68838	79	17	for	for	ADP
bibechana-68838	79	18	monomer	monomer	NOUN
bibechana-68838	79	19	and	and	CCONJ
bibechana-68838	79	20	0.5	0.5	NUM
bibechana-68838	79	21	for	for	ADP
bibechana-68838	79	22	multimer	multimer	NOUN
bibechana-68838	79	23	.	.	PUNCT
bibechana-68838	80	1	in	in	ADP
bibechana-68838	80	2	addition	addition	NOUN
bibechana-68838	80	3	,	,	PUNCT
bibechana-68838	80	4	we	we	PRON
bibechana-68838	80	5	used	use	VERB
bibechana-68838	80	6	a	a	DET
bibechana-68838	80	7	single	single	ADJ
bibechana-68838	80	8	random	random	ADJ
bibechana-68838	80	9	seed	seed	NOUN
bibechana-68838	80	10	to	to	PART
bibechana-68838	80	11	initialize	initialize	VERB
bibechana-68838	80	12	the	the	DET
bibechana-68838	80	13	prediction	prediction	NOUN
bibechana-68838	80	14	(	(	PUNCT
bibechana-68838	80	15	num_seed	num_seed	ADP
bibechana-68838	80	16	=	=	NOUN
bibechana-68838	80	17	1	1	NUM
bibechana-68838	80	18	)	)	PUNCT
bibechana-68838	80	19	.	.	PUNCT
bibechana-68838	81	1	similarly	similarly	ADV
bibechana-68838	81	2	,	,	PUNCT
bibechana-68838	81	3	to	to	PART
bibechana-68838	81	4	optimize	optimize	VERB
bibechana-68838	81	5	the	the	DET
bibechana-68838	81	6	msa	msa	PROPN
bibechana-68838	81	7	,	,	PUNCT
bibechana-68838	81	8	we	we	PRON
bibechana-68838	81	9	set	set	VERB
bibechana-68838	81	10	the	the	DET
bibechana-68838	81	11	max_msa	max_msa	ADJ
bibechana-68838	81	12	parameter	parameter	NOUN
bibechana-68838	81	13	to	to	ADP
bibechana-68838	81	14	auto	auto	NOUN
bibechana-68838	81	15	and	and	CCONJ
bibechana-68838	81	16	the	the	DET
bibechana-68838	81	17	msa_mod	msa_mod	NOUN
bibechana-68838	81	18	to	to	ADP
bibechana-68838	81	19	mmseqs2_uniref_env	mmseqs2_uniref_env	NOUN
bibechana-68838	81	20	.	.	PUNCT
bibechana-68838	82	1	similarly	similarly	ADV
bibechana-68838	82	2	,	,	PUNCT
bibechana-68838	82	3	we	we	PRON
bibechana-68838	82	4	used	use	VERB
bibechana-68838	82	5	the	the	DET
bibechana-68838	82	6	unpaired_paired	unpaired_paired	PROPN
bibechana-68838	82	7	pair_mod	pair_mod	PROPN
bibechana-68838	82	8	,	,	PUNCT
bibechana-68838	82	9	which	which	PRON
bibechana-68838	82	10	pairs	pair	VERB
bibechana-68838	82	11	sequences	sequence	NOUN
bibechana-68838	82	12	from	from	ADP
bibechana-68838	82	13	the	the	DET
bibechana-68838	82	14	same	same	ADJ
bibechana-68838	82	15	species	specie	NOUN
bibechana-68838	82	16	and	and	CCONJ
bibechana-68838	82	17	unpaired	unpaired	ADJ
bibechana-68838	82	18	msa	msa	PROPN
bibechana-68838	82	19	.	.	PUNCT
bibechana-68838	83	1	the	the	DET
bibechana-68838	83	2	rank	rank	NOUN
bibechana-68838	83	3	one	one	NUM
bibechana-68838	83	4	model	model	NOUN
bibechana-68838	83	5	predicted	predict	VERB
bibechana-68838	83	6	from	from	ADP
bibechana-68838	83	7	colabfold	colabfold	PROPN
bibechana-68838	83	8	was	be	AUX
bibechana-68838	83	9	used	use	VERB
bibechana-68838	83	10	as	as	ADP
bibechana-68838	83	11	the	the	DET
bibechana-68838	83	12	input	input	NOUN
bibechana-68838	83	13	structure	structure	NOUN
bibechana-68838	83	14	of	of	ADP
bibechana-68838	83	15	the	the	DET
bibechana-68838	83	16	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	83	17	complex	complex	NOUN
bibechana-68838	83	18	for	for	ADP
bibechana-68838	83	19	molecular	molecular	ADJ
bibechana-68838	83	20	dynamics	dynamic	NOUN
bibechana-68838	83	21	simulation	simulation	NOUN
bibechana-68838	83	22	and	and	CCONJ
bibechana-68838	83	23	further	further	ADJ
bibechana-68838	83	24	analysis	analysis	NOUN
bibechana-68838	83	25	.	.	PUNCT
bibechana-68838	84	1	2.2	2.2	NUM
bibechana-68838	84	2	system	system	NOUN
bibechana-68838	84	3	setup	setup	NOUN
bibechana-68838	84	4	and	and	CCONJ
bibechana-68838	84	5	molecular	molecular	ADJ
bibechana-68838	84	6	dynamics	dynamic	NOUN
bibechana-68838	84	7	simulations	simulation	VERB
bibechana-68838	84	8	the	the	DET
bibechana-68838	84	9	system	system	NOUN
bibechana-68838	84	10	input	input	NOUN
bibechana-68838	84	11	files	file	NOUN
bibechana-68838	84	12	for	for	ADP
bibechana-68838	84	13	the	the	DET
bibechana-68838	84	14	md	md	PROPN
bibechana-68838	84	15	simulation	simulation	NOUN
bibechana-68838	84	16	were	be	AUX
bibechana-68838	84	17	prepared	prepare	VERB
bibechana-68838	84	18	using	use	VERB
bibechana-68838	84	19	the	the	DET
bibechana-68838	84	20	solution	solution	NOUN
bibechana-68838	84	21	builder	builder	NOUN
bibechana-68838	84	22	package	package	NOUN
bibechana-68838	84	23	of	of	ADP
bibechana-68838	84	24	the	the	DET
bibechana-68838	84	25	charmm	charmm	NOUN
bibechana-68838	84	26	-	-	PUNCT
bibechana-68838	84	27	gui	gui	NOUN
bibechana-68838	84	28	web	web	NOUN
bibechana-68838	84	29	server	server	NOUN
bibechana-68838	84	30	[	[	X
bibechana-68838	84	31	31	31	NUM
bibechana-68838	84	32	]	]	PUNCT
bibechana-68838	84	33	.	.	PUNCT
bibechana-68838	85	1	the	the	DET
bibechana-68838	85	2	system	system	NOUN
bibechana-68838	85	3	was	be	AUX
bibechana-68838	85	4	solvated	solvate	VERB
bibechana-68838	85	5	using	use	VERB
bibechana-68838	85	6	tip	tip	NOUN
bibechana-68838	85	7	3p	3p	NUM
bibechana-68838	85	8	water	water	NOUN
bibechana-68838	85	9	in	in	ADP
bibechana-68838	85	10	a	a	DET
bibechana-68838	85	11	cubical	cubical	ADJ
bibechana-68838	85	12	box	box	NOUN
bibechana-68838	85	13	with	with	ADP
bibechana-68838	85	14	a	a	DET
bibechana-68838	85	15	10	10	NUM
bibechana-68838	85	16	å	å	NOUN
bibechana-68838	85	17	padding	padding	NOUN
bibechana-68838	85	18	around	around	ADP
bibechana-68838	85	19	the	the	DET
bibechana-68838	85	20	complex	complex	NOUN
bibechana-68838	85	21	and	and	CCONJ
bibechana-68838	85	22	neutralized	neutralize	VERB
bibechana-68838	85	23	by	by	ADP
bibechana-68838	85	24	adding	add	VERB
bibechana-68838	85	25	0.15	0.15	NUM
bibechana-68838	85	26	m	m	NOUN
bibechana-68838	85	27	of	of	ADP
bibechana-68838	85	28	nacl	nacl	NOUN
bibechana-68838	85	29	,	,	PUNCT
bibechana-68838	85	30	which	which	PRON
bibechana-68838	85	31	resulted	result	VERB
bibechana-68838	85	32	in	in	ADP
bibechana-68838	85	33	the	the	DET
bibechana-68838	85	34	system	system	NOUN
bibechana-68838	85	35	containing	contain	VERB
bibechana-68838	85	36	36,210	36,210	NUM
bibechana-68838	85	37	atoms	atom	NOUN
bibechana-68838	85	38	in	in	ADP
bibechana-68838	85	39	the	the	DET
bibechana-68838	85	40	box	box	NOUN
bibechana-68838	85	41	with	with	ADP
bibechana-68838	85	42	dimensions	dimension	NOUN
bibechana-68838	85	43	of	of	ADP
bibechana-68838	85	44	73	73	NUM
bibechana-68838	85	45	×	×	NOUN
bibechana-68838	85	46	73	73	NUM
bibechana-68838	85	47	×	×	NOUN
bibechana-68838	85	48	73	73	NUM
bibechana-68838	85	49	å3	å3	PROPN
bibechana-68838	85	50	.	.	PUNCT
bibechana-68838	86	1	all	all	DET
bibechana-68838	86	2	-	-	PUNCT
bibechana-68838	86	3	atom	atom	NOUN
bibechana-68838	86	4	md	md	PROPN
bibechana-68838	86	5	simulations	simulation	NOUN
bibechana-68838	86	6	were	be	AUX
bibechana-68838	86	7	performed	perform	VERB
bibechana-68838	86	8	with	with	ADP
bibechana-68838	86	9	the	the	DET
bibechana-68838	86	10	namd	namd	ADJ
bibechana-68838	86	11	2.14	2.14	NUM
bibechana-68838	86	12	package	package	NOUN
bibechana-68838	86	13	[	[	X
bibechana-68838	86	14	32	32	NUM
bibechana-68838	86	15	]	]	PUNCT
bibechana-68838	86	16	using	use	VERB
bibechana-68838	86	17	charmm36	charmm36	NOUN
bibechana-68838	86	18	m	m	PROPN
bibechana-68838	86	19	force	force	NOUN
bibechana-68838	86	20	field	field	NOUN
bibechana-68838	86	21	[	[	X
bibechana-68838	86	22	33	33	NUM
bibechana-68838	86	23	]	]	PUNCT
bibechana-68838	86	24	,	,	PUNCT
bibechana-68838	86	25	an	an	DET
bibechana-68838	86	26	improved	improved	ADJ
bibechana-68838	86	27	force	force	NOUN
bibechana-68838	86	28	field	field	NOUN
bibechana-68838	86	29	for	for	ADP
bibechana-68838	86	30	folded	folded	ADJ
bibechana-68838	86	31	and	and	CCONJ
bibechana-68838	86	32	intrinsically	intrinsically	ADV
bibechana-68838	86	33	disordered	disordered	ADJ
bibechana-68838	86	34	protein	protein	NOUN
bibechana-68838	86	35	.	.	PUNCT
bibechana-68838	87	1	standard	standard	PROPN
bibechana-68838	87	2	md	md	PROPN
bibechana-68838	87	3	protocol	protocol	PROPN
bibechana-68838	87	4	was	be	AUX
bibechana-68838	87	5	followed	follow	VERB
bibechana-68838	87	6	for	for	ADP
bibechana-68838	87	7	the	the	DET
bibechana-68838	87	8	simulation	simulation	NOUN
bibechana-68838	87	9	as	as	ADP
bibechana-68838	87	10	in	in	ADP
bibechana-68838	87	11	our	our	PRON
bibechana-68838	87	12	previous	previous	ADJ
bibechana-68838	87	13	works	work	NOUN
bibechana-68838	87	14	.	.	PUNCT
bibechana-68838	88	1	[	[	X
bibechana-68838	88	2	34–36	34–36	NUM
bibechana-68838	88	3	]	]	PUNCT
bibechana-68838	88	4	.	.	PUNCT
bibechana-68838	89	1	briefly	briefly	NOUN
bibechana-68838	89	2	,	,	PUNCT
bibechana-68838	89	3	the	the	DET
bibechana-68838	89	4	energy	energy	NOUN
bibechana-68838	89	5	minimization	minimization	NOUN
bibechana-68838	89	6	of	of	ADP
bibechana-68838	89	7	the	the	DET
bibechana-68838	89	8	system	system	NOUN
bibechana-68838	89	9	was	be	AUX
bibechana-68838	89	10	carried	carry	VERB
bibechana-68838	89	11	out	out	ADP
bibechana-68838	89	12	for	for	ADP
bibechana-68838	89	13	10,000	10,000	NUM
bibechana-68838	89	14	steps	step	NOUN
bibechana-68838	89	15	using	use	VERB
bibechana-68838	89	16	the	the	DET
bibechana-68838	89	17	conjugate	conjugate	ADJ
bibechana-68838	89	18	gradient	gradient	NOUN
bibechana-68838	89	19	and	and	CCONJ
bibechana-68838	89	20	line	line	NOUN
bibechana-68838	89	21	search	search	NOUN
bibechana-68838	89	22	algorithm	algorithm	NOUN
bibechana-68838	89	23	.	.	PUNCT
bibechana-68838	90	1	the	the	DET
bibechana-68838	90	2	equilibration	equilibration	NOUN
bibechana-68838	90	3	run	run	NOUN
bibechana-68838	90	4	was	be	AUX
bibechana-68838	90	5	performed	perform	VERB
bibechana-68838	90	6	for	for	ADP
bibechana-68838	90	7	125	125	NUM
bibechana-68838	90	8	ps	ps	NOUN
bibechana-68838	90	9	with	with	ADP
bibechana-68838	90	10	a	a	DET
bibechana-68838	90	11	1	1	NUM
bibechana-68838	90	12	fs	fs	NOUN
bibechana-68838	90	13	integration	integration	NOUN
bibechana-68838	90	14	time	time	NOUN
bibechana-68838	90	15	step	step	NOUN
bibechana-68838	90	16	at	at	ADP
bibechana-68838	90	17	300k	300k	PROPN
bibechana-68838	90	18	.	.	PUNCT
bibechana-68838	91	1	during	during	ADP
bibechana-68838	91	2	the	the	DET
bibechana-68838	91	3	equilibration	equilibration	NOUN
bibechana-68838	91	4	run	run	NOUN
bibechana-68838	91	5	,	,	PUNCT
bibechana-68838	91	6	the	the	DET
bibechana-68838	91	7	protein	protein	NOUN
bibechana-68838	91	8	’s	’s	PART
bibechana-68838	91	9	heavy	heavy	ADJ
bibechana-68838	91	10	atoms	atom	NOUN
bibechana-68838	91	11	were	be	AUX
bibechana-68838	91	12	harmonically	harmonically	ADV
bibechana-68838	91	13	restrained	restrain	VERB
bibechana-68838	91	14	with	with	ADP
bibechana-68838	91	15	a	a	DET
bibechana-68838	91	16	force	force	NOUN
bibechana-68838	91	17	constant	constant	ADJ
bibechana-68838	91	18	of	of	ADP
bibechana-68838	91	19	1.0	1.0	NUM
bibechana-68838	91	20	kcal	kcal	NOUN
bibechana-68838	91	21	/	/	SYM
bibechana-68838	91	22	mol	mol	PROPN
bibechana-68838	91	23	/	/	SYM
bibechana-68838	91	24	å	å	PROPN
bibechana-68838	91	25	for	for	ADP
bibechana-68838	91	26	the	the	DET
bibechana-68838	91	27	backbone	backbone	NOUN
bibechana-68838	91	28	and	and	CCONJ
bibechana-68838	91	29	0.1	0.1	NUM
bibechana-68838	91	30	kcal	kcal	NOUN
bibechana-68838	91	31	/	/	SYM
bibechana-68838	91	32	mol	mol	PROPN
bibechana-68838	91	33	/	/	SYM
bibechana-68838	91	34	å	å	PROPN
bibechana-68838	91	35	for	for	ADP
bibechana-68838	91	36	the	the	DET
bibechana-68838	91	37	side	side	NOUN
bibechana-68838	91	38	chain	chain	NOUN
bibechana-68838	91	39	.	.	PUNCT
bibechana-68838	92	1	the	the	DET
bibechana-68838	92	2	particle	particle	NOUN
bibechana-68838	92	3	mesh	mesh	PROPN
bibechana-68838	92	4	ewald	ewald	PROPN
bibechana-68838	92	5	(	(	PUNCT
bibechana-68838	92	6	pme	pme	PROPN
bibechana-68838	92	7	)	)	PUNCT
bibechana-68838	92	8	method	method	NOUN
bibechana-68838	92	9	[	[	X
bibechana-68838	92	10	37	37	NUM
bibechana-68838	92	11	]	]	PUNCT
bibechana-68838	92	12	was	be	AUX
bibechana-68838	92	13	employed	employ	VERB
bibechana-68838	92	14	to	to	PART
bibechana-68838	92	15	calculate	calculate	VERB
bibechana-68838	92	16	the	the	DET
bibechana-68838	92	17	long	long	ADJ
bibechana-68838	92	18	-	-	PUNCT
bibechana-68838	92	19	range	range	NOUN
bibechana-68838	92	20	interactions	interaction	NOUN
bibechana-68838	92	21	.	.	PUNCT
bibechana-68838	93	1	the	the	DET
bibechana-68838	93	2	cut	cut	VERB
bibechana-68838	93	3	-	-	PUNCT
bibechana-68838	93	4	off	off	ADP
bibechana-68838	93	5	distance	distance	NOUN
bibechana-68838	93	6	of	of	ADP
bibechana-68838	93	7	12	12	NUM
bibechana-68838	93	8	å	å	PROPN
bibechana-68838	93	9	taken	take	VERB
bibechana-68838	93	10	for	for	ADP
bibechana-68838	93	11	non	non	ADJ
bibechana-68838	93	12	-	-	ADJ
bibechana-68838	93	13	bonded	bond	VERB
bibechana-68838	93	14	interactions	interaction	NOUN
bibechana-68838	93	15	.	.	PUNCT
bibechana-68838	94	1	the	the	DET
bibechana-68838	94	2	nosé	nosé	PROPN
bibechana-68838	94	3	hoover	hoover	PROPN
bibechana-68838	94	4	langevin	langevin	PROPN
bibechana-68838	94	5	method	method	NOUN
bibechana-68838	94	6	with	with	ADP
bibechana-68838	94	7	a	a	DET
bibechana-68838	94	8	piston	piston	NOUN
bibechana-68838	94	9	period	period	NOUN
bibechana-68838	94	10	of	of	ADP
bibechana-68838	94	11	50	50	NUM
bibechana-68838	94	12	fs	f	NOUN
bibechana-68838	94	13	and	and	CCONJ
bibechana-68838	94	14	a	a	DET
bibechana-68838	94	15	decay	decay	NOUN
bibechana-68838	94	16	of	of	ADP
bibechana-68838	94	17	25	25	NUM
bibechana-68838	94	18	fs	f	NOUN
bibechana-68838	94	19	was	be	AUX
bibechana-68838	94	20	used	use	VERB
bibechana-68838	94	21	to	to	PART
bibechana-68838	94	22	control	control	VERB
bibechana-68838	94	23	the	the	DET
bibechana-68838	94	24	pressure	pressure	NOUN
bibechana-68838	94	25	.	.	PUNCT
bibechana-68838	95	1	similarly	similarly	ADV
bibechana-68838	95	2	,	,	PUNCT
bibechana-68838	95	3	the	the	DET
bibechana-68838	95	4	temperature	temperature	NOUN
bibechana-68838	95	5	was	be	AUX
bibechana-68838	95	6	controlled	control	VERB
bibechana-68838	95	7	by	by	ADP
bibechana-68838	95	8	employing	employ	VERB
bibechana-68838	95	9	the	the	DET
bibechana-68838	95	10	langevin	langevin	ADJ
bibechana-68838	95	11	temperature	temperature	NOUN
bibechana-68838	95	12	coupling	coupling	NOUN
bibechana-68838	95	13	with	with	ADP
bibechana-68838	95	14	a	a	DET
bibechana-68838	95	15	friction	friction	NOUN
bibechana-68838	95	16	coefficient	coefficient	NOUN
bibechana-68838	95	17	of	of	ADP
bibechana-68838	95	18	1ps-1	1ps-1	NUM
bibechana-68838	95	19	.	.	PUNCT
bibechana-68838	96	1	the	the	DET
bibechana-68838	96	2	production	production	NOUN
bibechana-68838	96	3	run	run	NOUN
bibechana-68838	96	4	was	be	AUX
bibechana-68838	96	5	propagated	propagate	VERB
bibechana-68838	96	6	for	for	ADP
bibechana-68838	96	7	350	350	NUM
bibechana-68838	96	8	ns	ns	NUM
bibechana-68838	96	9	in	in	ADP
bibechana-68838	96	10	npt	npt	PROPN
bibechana-68838	96	11	condition	condition	NOUN
bibechana-68838	96	12	at	at	ADP
bibechana-68838	96	13	300	300	NUM
bibechana-68838	96	14	k	k	NOUN
bibechana-68838	96	15	and	and	CCONJ
bibechana-68838	96	16	1	1	NUM
bibechana-68838	96	17	atm	atm	NOUN
bibechana-68838	96	18	pressure	pressure	NOUN
bibechana-68838	96	19	,	,	PUNCT
bibechana-68838	96	20	taking	take	VERB
bibechana-68838	96	21	a	a	DET
bibechana-68838	96	22	2	2	NUM
bibechana-68838	96	23	fs	fs	NOUN
bibechana-68838	96	24	time	time	NOUN
bibechana-68838	96	25	step	step	NOUN
bibechana-68838	96	26	.	.	PUNCT
bibechana-68838	97	1	2.3	2.3	NUM
bibechana-68838	97	2	system	system	NOUN
bibechana-68838	97	3	setup	setup	NOUN
bibechana-68838	97	4	and	and	CCONJ
bibechana-68838	97	5	molecular	molecular	ADJ
bibechana-68838	97	6	dynamics	dynamic	NOUN
bibechana-68838	97	7	simulations	simulation	VERB
bibechana-68838	97	8	the	the	DET
bibechana-68838	97	9	md	md	PROPN
bibechana-68838	97	10	simulation	simulation	PROPN
bibechana-68838	97	11	trajectories	trajectory	NOUN
bibechana-68838	97	12	were	be	AUX
bibechana-68838	97	13	analyzed	analyze	VERB
bibechana-68838	97	14	using	use	VERB
bibechana-68838	97	15	visual	visual	ADJ
bibechana-68838	97	16	molecular	molecular	ADJ
bibechana-68838	97	17	dynamics	dynamic	NOUN
bibechana-68838	97	18	(	(	PUNCT
bibechana-68838	97	19	vmd	vmd	NOUN
bibechana-68838	97	20	)	)	PUNCT
bibechana-68838	98	1	[	[	X
bibechana-68838	98	2	38	38	NUM
bibechana-68838	98	3	]	]	PUNCT
bibechana-68838	98	4	.	.	PUNCT
bibechana-68838	99	1	vmd	vmd	PROPN
bibechana-68838	99	2	was	be	AUX
bibechana-68838	99	3	also	also	ADV
bibechana-68838	99	4	used	use	VERB
bibechana-68838	99	5	for	for	ADP
bibechana-68838	99	6	visualization	visualization	NOUN
bibechana-68838	99	7	and	and	CCONJ
bibechana-68838	99	8	image	image	NOUN
bibechana-68838	99	9	rendering	rendering	NOUN
bibechana-68838	99	10	purposes	purpose	NOUN
bibechana-68838	99	11	.	.	PUNCT
bibechana-68838	100	1	the	the	DET
bibechana-68838	100	2	mm	mm	PROPN
bibechana-68838	100	3	/	/	SYM
bibechana-68838	100	4	gbsa	gbsa	ADJ
bibechana-68838	100	5	binding	bind	VERB
bibechana-68838	100	6	free	free	ADJ
bibechana-68838	100	7	energy	energy	NOUN
bibechana-68838	100	8	was	be	AUX
bibechana-68838	100	9	estimated	estimate	VERB
bibechana-68838	100	10	using	use	VERB
bibechana-68838	100	11	namd	namd	NOUN
bibechana-68838	100	12	.	.	PUNCT
bibechana-68838	101	1	the	the	DET
bibechana-68838	101	2	hydrogen	hydrogen	NOUN
bibechana-68838	101	3	bond	bond	NOUN
bibechana-68838	101	4	plugin	plugin	NOUN
bibechana-68838	101	5	in	in	ADP
bibechana-68838	101	6	vmd	vmd	PROPN
bibechana-68838	101	7	was	be	AUX
bibechana-68838	101	8	used	use	VERB
bibechana-68838	101	9	to	to	PART
bibechana-68838	101	10	analyze	analyze	VERB
bibechana-68838	101	11	the	the	DET
bibechana-68838	101	12	complex	complex	NOUN
bibechana-68838	101	13	's	's	PART
bibechana-68838	101	14	inter	inter	ADJ
bibechana-68838	101	15	-	-	ADJ
bibechana-68838	101	16	protein	protein	ADJ
bibechana-68838	101	17	hydrogen	hydrogen	NOUN
bibechana-68838	101	18	bonding	bonding	NOUN
bibechana-68838	101	19	.	.	PUNCT
bibechana-68838	102	1	the	the	DET
bibechana-68838	102	2	heavy	heavy	ADJ
bibechana-68838	102	3	atom	atom	NOUN
bibechana-68838	102	4	distance	distance	NOUN
bibechana-68838	102	5	cut	cut	NOUN
bibechana-68838	102	6	-	-	PUNCT
bibechana-68838	102	7	off	off	NOUN
bibechana-68838	102	8	of	of	ADP
bibechana-68838	102	9	3.5	3.5	NUM
bibechana-68838	102	10	å	å	NOUN
bibechana-68838	102	11	and	and	CCONJ
bibechana-68838	102	12	bond	bond	NOUN
bibechana-68838	102	13	angle	angle	NOUN
bibechana-68838	102	14	cut	cut	NOUN
bibechana-68838	102	15	-	-	PUNCT
bibechana-68838	102	16	off	off	NOUN
bibechana-68838	102	17	of	of	ADP
bibechana-68838	102	18	30	30	NUM
bibechana-68838	102	19	°	°	NOUN
bibechana-68838	102	20	were	be	AUX
bibechana-68838	102	21	used	use	VERB
bibechana-68838	102	22	to	to	PART
bibechana-68838	102	23	calculate	calculate	VERB
bibechana-68838	102	24	hydrogen	hydrogen	NOUN
bibechana-68838	102	25	bonds	bond	NOUN
bibechana-68838	102	26	.	.	PUNCT
bibechana-68838	103	1	similarly	similarly	ADV
bibechana-68838	103	2	,	,	PUNCT
bibechana-68838	103	3	the	the	DET
bibechana-68838	103	4	solvent	solvent	NOUN
bibechana-68838	103	5	-	-	PUNCT
bibechana-68838	103	6	accessible	accessible	ADJ
bibechana-68838	103	7	surface	surface	NOUN
bibechana-68838	103	8	area	area	NOUN
bibechana-68838	103	9	(	(	PUNCT
bibechana-68838	103	10	sasa	sasa	PROPN
bibechana-68838	103	11	)	)	PUNCT
bibechana-68838	103	12	of	of	ADP
bibechana-68838	103	13	the	the	DET
bibechana-68838	103	14	proteins	protein	NOUN
bibechana-68838	103	15	and	and	CCONJ
bibechana-68838	103	16	complex	complex	NOUN
bibechana-68838	103	17	was	be	AUX
bibechana-68838	103	18	estimated	estimate	VERB
bibechana-68838	103	19	using	use	VERB
bibechana-68838	103	20	vmd	vmd	PROPN
bibechana-68838	103	21	.	.	PUNCT
bibechana-68838	104	1	the	the	DET
bibechana-68838	104	2	non	non	ADJ
bibechana-68838	104	3	-	-	ADJ
bibechana-68838	104	4	bonded	bonded	ADJ
bibechana-68838	104	5	interaction	interaction	NOUN
bibechana-68838	104	6	energies	energy	NOUN
bibechana-68838	104	7	were	be	AUX
bibechana-68838	104	8	calculated	calculate	VERB
bibechana-68838	104	9	using	use	VERB
bibechana-68838	104	10	the	the	DET
bibechana-68838	104	11	namd	namd	ADJ
bibechana-68838	104	12	energy	energy	NOUN
bibechana-68838	104	13	plugin	plugin	NOUN
bibechana-68838	104	14	in	in	ADP
bibechana-68838	104	15	vmd	vmd	PROPN
bibechana-68838	104	16	.	.	PROPN
bibechana-68838	104	17	3	3	NUM
bibechana-68838	104	18	results	result	NOUN
bibechana-68838	104	19	and	and	CCONJ
bibechana-68838	104	20	discussion	discussion	NOUN
bibechana-68838	104	21	we	we	PRON
bibechana-68838	104	22	performed	perform	VERB
bibechana-68838	104	23	modeling	modeling	NOUN
bibechana-68838	104	24	and	and	CCONJ
bibechana-68838	104	25	md	md	PROPN
bibechana-68838	104	26	simulation	simulation	NOUN
bibechana-68838	104	27	to	to	PART
bibechana-68838	104	28	predict	predict	VERB
bibechana-68838	104	29	the	the	DET
bibechana-68838	104	30	complex	complex	NOUN
bibechana-68838	104	31	between	between	ADP
bibechana-68838	104	32	kaiso	kaiso	NOUN
bibechana-68838	104	33	and	and	CCONJ
bibechana-68838	104	34	ctcf	ctcf	NOUN
bibechana-68838	104	35	and	and	CCONJ
bibechana-68838	104	36	investigated	investigate	VERB
bibechana-68838	104	37	the	the	DET
bibechana-68838	104	38	structural	structural	ADJ
bibechana-68838	104	39	stability	stability	NOUN
bibechana-68838	104	40	and	and	CCONJ
bibechana-68838	104	41	dynamics	dynamic	NOUN
bibechana-68838	104	42	of	of	ADP
bibechana-68838	104	43	the	the	DET
bibechana-68838	104	44	interactions	interaction	NOUN
bibechana-68838	104	45	in	in	ADP
bibechana-68838	104	46	the	the	DET
bibechana-68838	104	47	kaiso	kaiso	NOUN
bibechana-68838	104	48	-	-	PUNCT
bibechana-68838	104	49	ctcf	ctcf	NOUN
bibechana-68838	104	50	complex	complex	NOUN
bibechana-68838	104	51	.	.	PUNCT
bibechana-68838	105	1	the	the	DET
bibechana-68838	105	2	optimum	optimum	ADJ
bibechana-68838	105	3	complex	complex	NOUN
bibechana-68838	105	4	between	between	ADP
bibechana-68838	105	5	kaiso	kaiso	NOUN
bibechana-68838	105	6	and	and	CCONJ
bibechana-68838	105	7	ctcf	ctcf	NOUN
bibechana-68838	105	8	was	be	AUX
bibechana-68838	105	9	predicted	predict	VERB
bibechana-68838	105	10	using	use	VERB
bibechana-68838	105	11	alphafold2	alphafold2	NOUN
bibechana-68838	105	12	-	-	PUNCT
bibechana-68838	105	13	multimer	multimer	NOUN
bibechana-68838	105	14	implemented	implement	VERB
bibechana-68838	105	15	in	in	ADP
bibechana-68838	105	16	google	google	PROPN
bibechana-68838	105	17	collaboratory	collaboratory	NOUN
bibechana-68838	105	18	,	,	PUNCT
bibechana-68838	105	19	colabfold	colabfold	ADJ
bibechana-68838	105	20	.	.	PUNCT
bibechana-68838	106	1	the	the	DET
bibechana-68838	106	2	md	md	PROPN
bibechana-68838	106	3	simulation	simulation	NOUN
bibechana-68838	106	4	was	be	AUX
bibechana-68838	106	5	employed	employ	VERB
bibechana-68838	106	6	to	to	PART
bibechana-68838	106	7	assess	assess	VERB
bibechana-68838	106	8	the	the	DET
bibechana-68838	106	9	structural	structural	ADJ
bibechana-68838	106	10	integrity	integrity	NOUN
bibechana-68838	106	11	of	of	ADP
bibechana-68838	106	12	the	the	DET
bibechana-68838	106	13	predicted	predict	VERB
bibechana-68838	106	14	complex	complex	NOUN
bibechana-68838	106	15	and	and	CCONJ
bibechana-68838	106	16	identify	identify	VERB
bibechana-68838	106	17	the	the	DET
bibechana-68838	106	18	major	major	ADJ
bibechana-68838	106	19	residues	residue	NOUN
bibechana-68838	106	20	involved	involve	VERB
bibechana-68838	106	21	in	in	ADP
bibechana-68838	106	22	forming	form	VERB
bibechana-68838	106	23	and	and	CCONJ
bibechana-68838	106	24	stabilizing	stabilize	VERB
bibechana-68838	106	25	the	the	DET
bibechana-68838	106	26	kaiso	kaiso	NOUN
bibechana-68838	106	27	-	-	PUNCT
bibechana-68838	106	28	ctcf	ctcf	NOUN
bibechana-68838	106	29	complex	complex	NOUN
bibechana-68838	106	30	.	.	PUNCT
bibechana-68838	107	1	in	in	ADP
bibechana-68838	107	2	addition	addition	NOUN
bibechana-68838	107	3	,	,	PUNCT
bibechana-68838	107	4	we	we	PRON
bibechana-68838	107	5	studied	study	VERB
bibechana-68838	107	6	the	the	DET
bibechana-68838	107	7	dynamics	dynamic	NOUN
bibechana-68838	107	8	of	of	ADP
bibechana-68838	107	9	the	the	DET
bibechana-68838	107	10	non	non	ADJ
bibechana-68838	107	11	-	-	ADJ
bibechana-68838	107	12	covalent	covalent	ADJ
bibechana-68838	107	13	interactions	interaction	NOUN
bibechana-68838	107	14	,	,	PUNCT
bibechana-68838	107	15	such	such	ADJ
bibechana-68838	107	16	as	as	ADP
bibechana-68838	107	17	hydrogen	hydrogen	NOUN
bibechana-68838	107	18	bonding	bonding	NOUN
bibechana-68838	107	19	,	,	PUNCT
bibechana-68838	107	20	hydrophobic	hydrophobic	NOUN
bibechana-68838	107	21	,	,	PUNCT
bibechana-68838	107	22	electrostatic	electrostatic	ADJ
bibechana-68838	107	23	,	,	PUNCT
bibechana-68838	107	24	and	and	CCONJ
bibechana-68838	107	25	van	van	PROPN
bibechana-68838	107	26	der	der	NOUN
bibechana-68838	107	27	waals	waal	NOUN
bibechana-68838	107	28	interactions	interaction	NOUN
bibechana-68838	107	29	,	,	PUNCT
bibechana-68838	107	30	during	during	ADP
bibechana-68838	107	31	the	the	DET
bibechana-68838	107	32	simulation	simulation	NOUN
bibechana-68838	107	33	.	.	PUNCT
bibechana-68838	108	1	we	we	PRON
bibechana-68838	108	2	also	also	ADV
bibechana-68838	108	3	estimated	estimate	VERB
bibechana-68838	108	4	the	the	DET
bibechana-68838	108	5	hydrophobic	hydrophobic	NOUN
bibechana-68838	108	6	contact	contact	NOUN
bibechana-68838	108	7	area	area	NOUN
bibechana-68838	108	8	between	between	ADP
bibechana-68838	108	9	kaiso	kaiso	NOUN
bibechana-68838	108	10	and	and	CCONJ
bibechana-68838	108	11	ctcf	ctcf	VERB
bibechana-68838	108	12	as	as	ADV
bibechana-68838	108	13	well	well	ADV
bibechana-68838	108	14	as	as	ADP
bibechana-68838	108	15	the	the	DET
bibechana-68838	108	16	binding	bind	VERB
bibechana-68838	108	17	free	free	ADJ
bibechana-68838	108	18	energy	energy	NOUN
bibechana-68838	108	19	of	of	ADP
bibechana-68838	108	20	the	the	DET
bibechana-68838	108	21	kaiso	kaiso	NOUN
bibechana-68838	108	22	-	-	PUNCT
bibechana-68838	108	23	ctcf	ctcf	NOUN
bibechana-68838	108	24	complex	complex	NOUN
bibechana-68838	108	25	.	.	PUNCT
bibechana-68838	109	1	bidhya	bidhya	PROPN
bibechana-68838	109	2	thapa	thapa	PROPN
bibechana-68838	109	3	and	and	CCONJ
bibechana-68838	109	4	narayan	narayan	PROPN
bibechana-68838	109	5	prasad	prasad	PROPN
bibechana-68838	109	6	adhikari/	adhikari/	NUM
bibechana-68838	109	7	bibechana	bibechana	NOUN
bibechana-68838	109	8	21	21	NUM
bibechana-68838	109	9	(	(	PUNCT
bibechana-68838	109	10	2024	2024	NUM
bibechana-68838	109	11	)	)	PUNCT
bibechana-68838	109	12	290	290	NUM
bibechana-68838	109	13	-	-	SYM
bibechana-68838	109	14	299	299	NUM
bibechana-68838	109	15	293	293	NUM
bibechana-68838	109	16	3.1	3.1	NUM
bibechana-68838	109	17	modeling	modeling	NOUN
bibechana-68838	109	18	of	of	ADP
bibechana-68838	109	19	the	the	DET
bibechana-68838	109	20	kaiso	kaiso	NOUN
bibechana-68838	109	21	-	-	PUNCT
bibechana-68838	109	22	ctcf	ctcf	NOUN
bibechana-68838	109	23	complex	complex	NOUN
bibechana-68838	109	24	the	the	DET
bibechana-68838	109	25	amino	amino	NOUN
bibechana-68838	109	26	acid	acid	NOUN
bibechana-68838	109	27	residues	residue	NOUN
bibechana-68838	109	28	641	641	NUM
bibechana-68838	109	29	-	-	SYM
bibechana-68838	109	30	727	727	NUM
bibechana-68838	109	31	in	in	ADP
bibechana-68838	109	32	the	the	DET
bibechana-68838	109	33	c	c	NOUN
bibechana-68838	109	34	-	-	PUNCT
bibechana-68838	109	35	terminal	terminal	ADJ
bibechana-68838	109	36	region	region	NOUN
bibechana-68838	109	37	of	of	ADP
bibechana-68838	109	38	ctcf	ctcf	NOUN
bibechana-68838	109	39	were	be	AUX
bibechana-68838	109	40	predicted	predict	VERB
bibechana-68838	109	41	to	to	PART
bibechana-68838	109	42	be	be	AUX
bibechana-68838	109	43	involved	involve	VERB
bibechana-68838	109	44	in	in	ADP
bibechana-68838	109	45	the	the	DET
bibechana-68838	109	46	interactions	interaction	NOUN
bibechana-68838	109	47	with	with	ADP
bibechana-68838	109	48	the	the	DET
bibechana-68838	109	49	btb	btb	NOUN
bibechana-68838	109	50	/	/	SYM
bibechana-68838	109	51	poz	poz	PROPN
bibechana-68838	109	52	domain	domain	NOUN
bibechana-68838	109	53	of	of	ADP
bibechana-68838	109	54	kaiso	kaiso	NOUN
bibechana-68838	110	1	[	[	X
bibechana-68838	110	2	25	25	NUM
bibechana-68838	110	3	]	]	PUNCT
bibechana-68838	110	4	.	.	PUNCT
bibechana-68838	111	1	based	base	VERB
bibechana-68838	111	2	on	on	ADP
bibechana-68838	111	3	this	this	DET
bibechana-68838	111	4	information	information	NOUN
bibechana-68838	111	5	,	,	PUNCT
bibechana-68838	111	6	we	we	PRON
bibechana-68838	111	7	selected	select	VERB
bibechana-68838	111	8	641	641	NUM
bibechana-68838	111	9	-	-	SYM
bibechana-68838	111	10	727	727	NUM
bibechana-68838	111	11	residues	residue	NOUN
bibechana-68838	111	12	from	from	ADP
bibechana-68838	111	13	the	the	DET
bibechana-68838	111	14	canonical	canonical	ADJ
bibechana-68838	111	15	sequence	sequence	NOUN
bibechana-68838	111	16	of	of	ADP
bibechana-68838	111	17	ctcf	ctcf	NOUN
bibechana-68838	111	18	and	and	CCONJ
bibechana-68838	111	19	used	use	VERB
bibechana-68838	111	20	them	they	PRON
bibechana-68838	111	21	to	to	PART
bibechana-68838	111	22	create	create	VERB
bibechana-68838	111	23	a	a	DET
bibechana-68838	111	24	complex	complex	NOUN
bibechana-68838	111	25	with	with	ADP
bibechana-68838	111	26	the	the	DET
bibechana-68838	111	27	btb	btb	NOUN
bibechana-68838	111	28	/	/	SYM
bibechana-68838	111	29	poz	poz	PROPN
bibechana-68838	111	30	domain	domain	NOUN
bibechana-68838	111	31	of	of	ADP
bibechana-68838	111	32	kaiso	kaiso	NOUN
bibechana-68838	111	33	.	.	PUNCT
bibechana-68838	112	1	as	as	SCONJ
bibechana-68838	112	2	shown	show	VERB
bibechana-68838	112	3	in	in	ADP
bibechana-68838	112	4	figure	figure	NOUN
bibechana-68838	112	5	1a	1a	NOUN
bibechana-68838	112	6	,	,	PUNCT
bibechana-68838	112	7	the	the	DET
bibechana-68838	112	8	cterminal	cterminal	ADJ
bibechana-68838	112	9	region	region	NOUN
bibechana-68838	112	10	of	of	ADP
bibechana-68838	112	11	ctcf	ctcf	PROPN
bibechana-68838	112	12	is	be	AUX
bibechana-68838	112	13	the	the	DET
bibechana-68838	112	14	unstructured	unstructured	ADJ
bibechana-68838	112	15	loop	loop	NOUN
bibechana-68838	112	16	.	.	PUNCT
bibechana-68838	113	1	solving	solve	VERB
bibechana-68838	113	2	the	the	DET
bibechana-68838	113	3	crystal	crystal	NOUN
bibechana-68838	113	4	structure	structure	NOUN
bibechana-68838	113	5	of	of	ADP
bibechana-68838	113	6	the	the	DET
bibechana-68838	113	7	protein	protein	NOUN
bibechana-68838	113	8	-	-	PUNCT
bibechana-68838	113	9	protein	protein	NOUN
bibechana-68838	113	10	complex	complex	NOUN
bibechana-68838	113	11	with	with	ADP
bibechana-68838	113	12	large	large	ADJ
bibechana-68838	113	13	unstructured	unstructured	ADJ
bibechana-68838	113	14	loops	loop	NOUN
bibechana-68838	113	15	is	be	AUX
bibechana-68838	113	16	experimentally	experimentally	ADV
bibechana-68838	113	17	challenging	challenging	ADJ
bibechana-68838	113	18	.	.	PUNCT
bibechana-68838	114	1	in	in	ADP
bibechana-68838	114	2	such	such	ADJ
bibechana-68838	114	3	conditions	condition	NOUN
bibechana-68838	114	4	,	,	PUNCT
bibechana-68838	114	5	computational	computational	ADJ
bibechana-68838	114	6	techniques	technique	NOUN
bibechana-68838	114	7	such	such	ADJ
bibechana-68838	114	8	as	as	ADP
bibechana-68838	114	9	molecular	molecular	ADJ
bibechana-68838	114	10	modeling	modeling	NOUN
bibechana-68838	114	11	and	and	CCONJ
bibechana-68838	114	12	md	md	PROPN
bibechana-68838	114	13	simulations	simulation	NOUN
bibechana-68838	114	14	guide	guide	VERB
bibechana-68838	114	15	the	the	DET
bibechana-68838	114	16	structure	structure	NOUN
bibechana-68838	114	17	prediction	prediction	NOUN
bibechana-68838	114	18	and	and	CCONJ
bibechana-68838	114	19	characterization	characterization	NOUN
bibechana-68838	114	20	.	.	PUNCT
bibechana-68838	115	1	the	the	DET
bibechana-68838	115	2	ctcf	ctcf	NOUN
bibechana-68838	115	3	residues	residue	VERB
bibechana-68838	115	4	641	641	NUM
bibechana-68838	115	5	-	-	SYM
bibechana-68838	115	6	727	727	NUM
bibechana-68838	115	7	were	be	AUX
bibechana-68838	115	8	predicted	predict	VERB
bibechana-68838	115	9	to	to	PART
bibechana-68838	115	10	be	be	AUX
bibechana-68838	115	11	involved	involve	VERB
bibechana-68838	115	12	in	in	ADP
bibechana-68838	115	13	the	the	DET
bibechana-68838	115	14	interactions	interaction	NOUN
bibechana-68838	115	15	with	with	ADP
bibechana-68838	115	16	the	the	DET
bibechana-68838	115	17	btb	btb	NOUN
bibechana-68838	115	18	/	/	SYM
bibechana-68838	115	19	poz	poz	PROPN
bibechana-68838	115	20	domain	domain	NOUN
bibechana-68838	115	21	of	of	ADP
bibechana-68838	115	22	kaiso	kaiso	NOUN
bibechana-68838	116	1	[	[	X
bibechana-68838	116	2	25	25	NUM
bibechana-68838	116	3	]	]	PUNCT
bibechana-68838	116	4	.	.	PUNCT
bibechana-68838	117	1	based	base	VERB
bibechana-68838	117	2	on	on	ADP
bibechana-68838	117	3	this	this	DET
bibechana-68838	117	4	information	information	NOUN
bibechana-68838	117	5	,	,	PUNCT
bibechana-68838	117	6	we	we	PRON
bibechana-68838	117	7	selected	select	VERB
bibechana-68838	117	8	640	640	NUM
bibechana-68838	117	9	-	-	SYM
bibechana-68838	117	10	727	727	NUM
bibechana-68838	117	11	residues	residue	NOUN
bibechana-68838	117	12	from	from	ADP
bibechana-68838	117	13	the	the	DET
bibechana-68838	117	14	canonical	canonical	ADJ
bibechana-68838	117	15	sequence	sequence	NOUN
bibechana-68838	117	16	of	of	ADP
bibechana-68838	117	17	ctcf	ctcf	NOUN
bibechana-68838	117	18	and	and	CCONJ
bibechana-68838	117	19	btb	btb	VERB
bibechana-68838	117	20	/	/	SYM
bibechana-68838	117	21	poz	poz	PROPN
bibechana-68838	117	22	domain	domain	NOUN
bibechana-68838	117	23	residues	residue	VERB
bibechana-68838	117	24	1	1	NUM
bibechana-68838	117	25	-	-	SYM
bibechana-68838	117	26	120	120	NUM
bibechana-68838	117	27	of	of	ADP
bibechana-68838	117	28	kaiso	kaiso	NOUN
bibechana-68838	117	29	as	as	ADP
bibechana-68838	117	30	the	the	DET
bibechana-68838	117	31	input	input	NOUN
bibechana-68838	117	32	sequence	sequence	NOUN
bibechana-68838	117	33	in	in	ADP
bibechana-68838	117	34	the	the	DET
bibechana-68838	117	35	colabfold	colabfold	ADJ
bibechana-68838	117	36	v1.5.5	v1.5.5	NOUN
bibechana-68838	117	37	:	:	PUNCT
bibechana-68838	117	38	alphafold2	alphafold2	ADJ
bibechana-68838	117	39	using	use	VERB
bibechana-68838	117	40	mmseqs2	mmseqs2	PROPN
bibechana-68838	117	41	to	to	PART
bibechana-68838	117	42	predict	predict	VERB
bibechana-68838	117	43	the	the	DET
bibechana-68838	117	44	complex	complex	NOUN
bibechana-68838	117	45	.	.	PUNCT
bibechana-68838	118	1	the	the	DET
bibechana-68838	118	2	kaiso	kaiso	NOUN
bibechana-68838	118	3	-	-	PUNCT
bibechana-68838	118	4	ctcf	ctcf	NOUN
bibechana-68838	118	5	complex	complex	NOUN
bibechana-68838	118	6	was	be	AUX
bibechana-68838	118	7	predicted	predict	VERB
bibechana-68838	118	8	using	use	VERB
bibechana-68838	118	9	the	the	DET
bibechana-68838	118	10	alphafold2_multimer_v3	alphafold2_multimer_v3	NOUN
bibechana-68838	118	11	prediction	prediction	NOUN
bibechana-68838	118	12	model	model	NOUN
bibechana-68838	118	13	.	.	PUNCT
bibechana-68838	119	1	the	the	DET
bibechana-68838	119	2	materials	material	NOUN
bibechana-68838	119	3	and	and	CCONJ
bibechana-68838	119	4	methods	method	NOUN
bibechana-68838	119	5	section	section	NOUN
bibechana-68838	119	6	explains	explain	VERB
bibechana-68838	119	7	the	the	DET
bibechana-68838	119	8	details	detail	NOUN
bibechana-68838	119	9	of	of	ADP
bibechana-68838	119	10	the	the	DET
bibechana-68838	119	11	parameters	parameter	NOUN
bibechana-68838	119	12	and	and	CCONJ
bibechana-68838	119	13	conditions	condition	NOUN
bibechana-68838	119	14	used	use	VERB
bibechana-68838	119	15	for	for	ADP
bibechana-68838	119	16	the	the	DET
bibechana-68838	119	17	complex	complex	ADJ
bibechana-68838	119	18	prediction	prediction	NOUN
bibechana-68838	119	19	.	.	PUNCT
bibechana-68838	120	1	we	we	PRON
bibechana-68838	120	2	chose	choose	VERB
bibechana-68838	120	3	the	the	DET
bibechana-68838	120	4	complex	complex	NOUN
bibechana-68838	120	5	with	with	ADP
bibechana-68838	120	6	rank	rank	PROPN
bibechana-68838	120	7	one	one	NUM
bibechana-68838	120	8	,	,	PUNCT
bibechana-68838	120	9	with	with	ADP
bibechana-68838	120	10	a	a	DET
bibechana-68838	120	11	predicted	predict	VERB
bibechana-68838	120	12	local	local	ADJ
bibechana-68838	120	13	distance	distance	NOUN
bibechana-68838	120	14	difference	difference	NOUN
bibechana-68838	120	15	test	test	NOUN
bibechana-68838	120	16	(	(	PUNCT
bibechana-68838	120	17	plddt	plddt	NOUN
bibechana-68838	120	18	)	)	PUNCT
bibechana-68838	120	19	score	score	NOUN
bibechana-68838	120	20	of	of	ADP
bibechana-68838	120	21	75.5	75.5	NUM
bibechana-68838	120	22	and	and	CCONJ
bibechana-68838	120	23	a	a	DET
bibechana-68838	120	24	predicted	predict	VERB
bibechana-68838	120	25	template	template	NOUN
bibechana-68838	120	26	modeling	modeling	NOUN
bibechana-68838	120	27	(	(	PUNCT
bibechana-68838	120	28	ptm	ptm	NOUN
bibechana-68838	120	29	)	)	PUNCT
bibechana-68838	120	30	score	score	NOUN
bibechana-68838	120	31	of	of	ADP
bibechana-68838	120	32	0.65	0.65	NUM
bibechana-68838	120	33	.	.	PUNCT
bibechana-68838	121	1	the	the	DET
bibechana-68838	121	2	ptm	ptm	PROPN
bibechana-68838	121	3	score	score	NOUN
bibechana-68838	121	4	greater	great	ADJ
bibechana-68838	121	5	than	than	ADP
bibechana-68838	121	6	0.5	0.5	NUM
bibechana-68838	121	7	indicates	indicate	VERB
bibechana-68838	121	8	that	that	SCONJ
bibechana-68838	121	9	the	the	DET
bibechana-68838	121	10	predicted	predict	VERB
bibechana-68838	121	11	complex	complex	NOUN
bibechana-68838	121	12	is	be	AUX
bibechana-68838	121	13	close	close	ADJ
bibechana-68838	121	14	to	to	ADP
bibechana-68838	121	15	the	the	DET
bibechana-68838	121	16	true	true	ADJ
bibechana-68838	121	17	structure	structure	NOUN
bibechana-68838	121	18	.	.	PUNCT
bibechana-68838	122	1	since	since	SCONJ
bibechana-68838	122	2	the	the	DET
bibechana-68838	122	3	btb	btb	NOUN
bibechana-68838	122	4	/	/	SYM
bibechana-68838	122	5	poz	poz	PROPN
bibechana-68838	122	6	domain	domain	NOUN
bibechana-68838	122	7	of	of	ADP
bibechana-68838	122	8	kaiso	kaiso	NOUN
bibechana-68838	122	9	has	have	VERB
bibechana-68838	122	10	a	a	DET
bibechana-68838	122	11	stable	stable	ADJ
bibechana-68838	122	12	structural	structural	ADJ
bibechana-68838	122	13	domain	domain	NOUN
bibechana-68838	122	14	(	(	PUNCT
bibechana-68838	122	15	figure	figure	NOUN
bibechana-68838	122	16	1b	1b	NUM
bibechana-68838	122	17	)	)	PUNCT
bibechana-68838	122	18	,	,	PUNCT
bibechana-68838	122	19	the	the	DET
bibechana-68838	122	20	predicted	predict	VERB
bibechana-68838	122	21	lddt	lddt	NOUN
bibechana-68838	122	22	of	of	ADP
bibechana-68838	122	23	kaiso	kaiso	NOUN
bibechana-68838	122	24	residues	residue	NOUN
bibechana-68838	122	25	in	in	ADP
bibechana-68838	122	26	the	the	DET
bibechana-68838	122	27	range	range	NOUN
bibechana-68838	122	28	of	of	ADP
bibechana-68838	122	29	10	10	NUM
bibechana-68838	122	30	-	-	SYM
bibechana-68838	122	31	117	117	NUM
bibechana-68838	122	32	is	be	AUX
bibechana-68838	122	33	greater	great	ADJ
bibechana-68838	122	34	than	than	ADP
bibechana-68838	122	35	80	80	NUM
bibechana-68838	122	36	,	,	PUNCT
bibechana-68838	122	37	whereas	whereas	SCONJ
bibechana-68838	122	38	the	the	DET
bibechana-68838	122	39	lddt	lddt	NOUN
bibechana-68838	122	40	of	of	ADP
bibechana-68838	122	41	most	most	ADJ
bibechana-68838	122	42	of	of	ADP
bibechana-68838	122	43	the	the	DET
bibechana-68838	122	44	ctcf	ctcf	ADJ
bibechana-68838	122	45	residues	residue	NOUN
bibechana-68838	122	46	is	be	AUX
bibechana-68838	122	47	less	less	ADJ
bibechana-68838	122	48	than	than	ADP
bibechana-68838	122	49	50	50	NUM
bibechana-68838	122	50	.	.	PUNCT
bibechana-68838	123	1	however	however	ADV
bibechana-68838	123	2	,	,	PUNCT
bibechana-68838	123	3	the	the	DET
bibechana-68838	123	4	predicted	predict	VERB
bibechana-68838	123	5	lddt	lddt	ADJ
bibechana-68838	123	6	score	score	NOUN
bibechana-68838	123	7	of	of	ADP
bibechana-68838	123	8	the	the	DET
bibechana-68838	123	9	ctcf	ctcf	ADJ
bibechana-68838	123	10	residues	residue	NOUN
bibechana-68838	123	11	in	in	ADP
bibechana-68838	123	12	the	the	DET
bibechana-68838	123	13	range	range	NOUN
bibechana-68838	123	14	670690	670690	NUM
bibechana-68838	123	15	,	,	PUNCT
bibechana-68838	123	16	which	which	PRON
bibechana-68838	123	17	are	be	AUX
bibechana-68838	123	18	involved	involve	VERB
bibechana-68838	123	19	in	in	ADP
bibechana-68838	123	20	binding	bind	VERB
bibechana-68838	123	21	with	with	ADP
bibechana-68838	123	22	kaiso	kaiso	NOUN
bibechana-68838	123	23	,	,	PUNCT
bibechana-68838	123	24	is	be	AUX
bibechana-68838	123	25	greater	great	ADJ
bibechana-68838	123	26	than	than	ADP
bibechana-68838	123	27	60	60	NUM
bibechana-68838	123	28	.	.	PUNCT
bibechana-68838	124	1	figure	figure	NOUN
bibechana-68838	124	2	1c	1c	NOUN
bibechana-68838	124	3	shows	show	VERB
bibechana-68838	124	4	the	the	DET
bibechana-68838	124	5	kaiso	kaiso	NOUN
bibechana-68838	124	6	-	-	PUNCT
bibechana-68838	124	7	ctcf	ctcf	NOUN
bibechana-68838	124	8	complex	complex	NOUN
bibechana-68838	124	9	predicted	predict	VERB
bibechana-68838	124	10	by	by	ADP
bibechana-68838	124	11	colabfold	colabfold	NOUN
bibechana-68838	124	12	.	.	PUNCT
bibechana-68838	125	1	since	since	SCONJ
bibechana-68838	125	2	all	all	DET
bibechana-68838	125	3	-	-	PUNCT
bibechana-68838	125	4	atom	atom	NOUN
bibechana-68838	125	5	md	md	PROPN
bibechana-68838	125	6	simulation	simulation	NOUN
bibechana-68838	125	7	is	be	AUX
bibechana-68838	125	8	computationally	computationally	ADV
bibechana-68838	125	9	expensive	expensive	ADJ
bibechana-68838	125	10	,	,	PUNCT
bibechana-68838	125	11	we	we	PRON
bibechana-68838	125	12	truncated	truncate	VERB
bibechana-68838	125	13	the	the	DET
bibechana-68838	125	14	complex	complex	NOUN
bibechana-68838	125	15	by	by	ADP
bibechana-68838	125	16	taking	take	VERB
bibechana-68838	125	17	the	the	DET
bibechana-68838	125	18	regions	region	NOUN
bibechana-68838	125	19	likely	likely	ADV
bibechana-68838	125	20	involved	involve	VERB
bibechana-68838	125	21	in	in	ADP
bibechana-68838	125	22	interactions	interaction	NOUN
bibechana-68838	125	23	.	.	PUNCT
bibechana-68838	126	1	since	since	SCONJ
bibechana-68838	126	2	only	only	ADV
bibechana-68838	126	3	the	the	DET
bibechana-68838	126	4	residues	residue	NOUN
bibechana-68838	126	5	666	666	NUM
bibechana-68838	126	6	-	-	SYM
bibechana-68838	126	7	690	690	NUM
bibechana-68838	126	8	in	in	ADP
bibechana-68838	126	9	ctcf	ctcf	NOUN
bibechana-68838	126	10	are	be	AUX
bibechana-68838	126	11	within	within	ADP
bibechana-68838	126	12	5	5	NUM
bibechana-68838	126	13	å	å	PROPN
bibechana-68838	126	14	of	of	ADP
bibechana-68838	126	15	kaiso	kaiso	NOUN
bibechana-68838	126	16	,	,	PUNCT
bibechana-68838	126	17	they	they	PRON
bibechana-68838	126	18	are	be	AUX
bibechana-68838	126	19	most	most	ADV
bibechana-68838	126	20	likely	likely	ADJ
bibechana-68838	126	21	to	to	PART
bibechana-68838	126	22	interact	interact	VERB
bibechana-68838	126	23	with	with	ADP
bibechana-68838	126	24	it	it	PRON
bibechana-68838	126	25	.	.	PUNCT
bibechana-68838	127	1	therefore	therefore	ADV
bibechana-68838	127	2	,	,	PUNCT
bibechana-68838	127	3	we	we	PRON
bibechana-68838	127	4	truncated	truncate	VERB
bibechana-68838	127	5	the	the	DET
bibechana-68838	127	6	predicted	predict	VERB
bibechana-68838	127	7	complex	complex	NOUN
bibechana-68838	127	8	by	by	ADP
bibechana-68838	127	9	taking	take	VERB
bibechana-68838	127	10	residues	residue	NOUN
bibechana-68838	127	11	662	662	NUM
bibechana-68838	127	12	-	-	SYM
bibechana-68838	127	13	692	692	NUM
bibechana-68838	127	14	for	for	ADP
bibechana-68838	127	15	ctcf	ctcf	NOUN
bibechana-68838	127	16	and	and	CCONJ
bibechana-68838	127	17	9	9	NUM
bibechana-68838	127	18	-	-	SYM
bibechana-68838	127	19	120	120	NUM
bibechana-68838	127	20	for	for	ADP
bibechana-68838	127	21	kaiso	kaiso	NOUN
bibechana-68838	127	22	.	.	PUNCT
bibechana-68838	128	1	as	as	SCONJ
bibechana-68838	128	2	the	the	DET
bibechana-68838	128	3	btb	btb	NOUN
bibechana-68838	128	4	/	/	SYM
bibechana-68838	128	5	poz	poz	PROPN
bibechana-68838	128	6	domain	domain	NOUN
bibechana-68838	128	7	of	of	ADP
bibechana-68838	128	8	kaiso	kaiso	NOUN
bibechana-68838	128	9	is	be	AUX
bibechana-68838	128	10	a	a	DET
bibechana-68838	128	11	stable	stable	ADJ
bibechana-68838	128	12	domain	domain	NOUN
bibechana-68838	128	13	,	,	PUNCT
bibechana-68838	128	14	we	we	PRON
bibechana-68838	128	15	have	have	AUX
bibechana-68838	128	16	taken	take	VERB
bibechana-68838	128	17	the	the	DET
bibechana-68838	128	18	entire	entire	ADJ
bibechana-68838	128	19	domain	domain	NOUN
bibechana-68838	128	20	as	as	ADP
bibechana-68838	128	21	an	an	DET
bibechana-68838	128	22	input	input	NOUN
bibechana-68838	128	23	structure	structure	NOUN
bibechana-68838	128	24	to	to	PART
bibechana-68838	128	25	maintain	maintain	VERB
bibechana-68838	128	26	its	its	PRON
bibechana-68838	128	27	stability	stability	NOUN
bibechana-68838	128	28	.	.	PUNCT
bibechana-68838	129	1	figure	figure	NOUN
bibechana-68838	129	2	1d	1d	NOUN
bibechana-68838	129	3	shows	show	VERB
bibechana-68838	129	4	the	the	DET
bibechana-68838	129	5	kaiso	kaiso	NOUN
bibechana-68838	129	6	-	-	PUNCT
bibechana-68838	129	7	ctcf	ctcf	NOUN
bibechana-68838	129	8	complex	complex	NOUN
bibechana-68838	129	9	used	use	VERB
bibechana-68838	129	10	for	for	ADP
bibechana-68838	129	11	all	all	DET
bibechana-68838	129	12	-	-	PUNCT
bibechana-68838	129	13	atom	atom	NOUN
bibechana-68838	129	14	md	md	PROPN
bibechana-68838	129	15	simulation	simulation	PROPN
bibechana-68838	129	16	.	.	PUNCT
bibechana-68838	130	1	the	the	DET
bibechana-68838	130	2	predicted	predict	VERB
bibechana-68838	130	3	kaiso	kaiso	NOUN
bibechana-68838	130	4	-	-	PUNCT
bibechana-68838	130	5	ctcf	ctcf	NOUN
bibechana-68838	130	6	complex	complex	NOUN
bibechana-68838	130	7	is	be	AUX
bibechana-68838	130	8	stable	stable	ADJ
bibechana-68838	130	9	throughout	throughout	ADP
bibechana-68838	130	10	the	the	DET
bibechana-68838	130	11	simulation	simulation	NOUN
bibechana-68838	130	12	and	and	CCONJ
bibechana-68838	130	13	features	feature	VERB
bibechana-68838	130	14	several	several	ADJ
bibechana-68838	130	15	interprotein	interprotein	ADJ
bibechana-68838	130	16	interactions	interaction	NOUN
bibechana-68838	130	17	that	that	PRON
bibechana-68838	130	18	stabilize	stabilize	VERB
bibechana-68838	130	19	it	it	PRON
bibechana-68838	130	20	,	,	PUNCT
bibechana-68838	130	21	as	as	SCONJ
bibechana-68838	130	22	shown	show	VERB
bibechana-68838	130	23	in	in	ADP
bibechana-68838	130	24	figure	figure	NOUN
bibechana-68838	130	25	2a	2a	NUM
bibechana-68838	130	26	.	.	PUNCT
bibechana-68838	131	1	figure	figure	NOUN
bibechana-68838	131	2	1	1	NUM
bibechana-68838	131	3	:	:	PUNCT
bibechana-68838	131	4	(	(	PUNCT
bibechana-68838	131	5	a	a	X
bibechana-68838	131	6	)	)	PUNCT
bibechana-68838	131	7	the	the	DET
bibechana-68838	131	8	full	full	ADJ
bibechana-68838	131	9	-	-	PUNCT
bibechana-68838	131	10	length	length	NOUN
bibechana-68838	131	11	structure	structure	NOUN
bibechana-68838	131	12	of	of	ADP
bibechana-68838	131	13	ctcf	ctcf	NOUN
bibechana-68838	131	14	highlighting	highlight	VERB
bibechana-68838	131	15	the	the	DET
bibechana-68838	131	16	residues	residue	NOUN
bibechana-68838	131	17	640	640	NUM
bibechana-68838	131	18	-	-	SYM
bibechana-68838	131	19	727	727	NUM
bibechana-68838	131	20	in	in	ADP
bibechana-68838	131	21	the	the	DET
bibechana-68838	131	22	c	c	NOUN
bibechana-68838	131	23	-	-	PUNCT
bibechana-68838	131	24	terminal	terminal	ADJ
bibechana-68838	131	25	domain	domain	NOUN
bibechana-68838	131	26	in	in	ADP
bibechana-68838	131	27	magenta	magenta	NOUN
bibechana-68838	131	28	.	.	PUNCT
bibechana-68838	132	1	(	(	PUNCT
bibechana-68838	132	2	b	b	X
bibechana-68838	132	3	)	)	PUNCT
bibechana-68838	132	4	the	the	DET
bibechana-68838	132	5	complete	complete	ADJ
bibechana-68838	132	6	structure	structure	NOUN
bibechana-68838	132	7	of	of	ADP
bibechana-68838	132	8	the	the	DET
bibechana-68838	132	9	kaiso	kaiso	NOUN
bibechana-68838	132	10	showing	show	VERB
bibechana-68838	132	11	the	the	DET
bibechana-68838	132	12	btb	btb	NOUN
bibechana-68838	132	13	/	/	SYM
bibechana-68838	132	14	poz	poz	PROPN
bibechana-68838	132	15	domain	domain	NOUN
bibechana-68838	132	16	in	in	ADP
bibechana-68838	132	17	green	green	NOUN
bibechana-68838	132	18	.	.	PUNCT
bibechana-68838	133	1	(	(	PUNCT
bibechana-68838	133	2	c	c	X
bibechana-68838	133	3	)	)	PUNCT
bibechana-68838	133	4	kaiso	kaiso	NOUN
bibechana-68838	133	5	-	-	PUNCT
bibechana-68838	133	6	ctcf	ctcf	NOUN
bibechana-68838	133	7	complex	complex	ADJ
bibechana-68838	133	8	structure	structure	NOUN
bibechana-68838	133	9	predicted	predict	VERB
bibechana-68838	133	10	from	from	ADP
bibechana-68838	133	11	colabfold	colabfold	ADJ
bibechana-68838	133	12	.	.	PUNCT
bibechana-68838	134	1	(	(	PUNCT
bibechana-68838	134	2	d	d	X
bibechana-68838	134	3	)	)	PUNCT
bibechana-68838	134	4	structure	structure	NOUN
bibechana-68838	134	5	of	of	ADP
bibechana-68838	134	6	the	the	DET
bibechana-68838	134	7	kaiso	kaiso	NOUN
bibechana-68838	134	8	-	-	PUNCT
bibechana-68838	134	9	ctcf	ctcf	NOUN
bibechana-68838	134	10	complex	complex	NOUN
bibechana-68838	134	11	used	use	VERB
bibechana-68838	134	12	for	for	ADP
bibechana-68838	134	13	the	the	DET
bibechana-68838	134	14	md	md	PROPN
bibechana-68838	134	15	simulation	simulation	PROPN
bibechana-68838	134	16	.	.	PUNCT
bibechana-68838	135	1	3.2	3.2	NUM
bibechana-68838	135	2	structural	structural	ADJ
bibechana-68838	135	3	stability	stability	NOUN
bibechana-68838	135	4	of	of	ADP
bibechana-68838	135	5	the	the	DET
bibechana-68838	135	6	complex	complex	NOUN
bibechana-68838	135	7	we	we	PRON
bibechana-68838	135	8	estimated	estimate	VERB
bibechana-68838	135	9	the	the	DET
bibechana-68838	135	10	root	root	NOUN
bibechana-68838	135	11	mean	mean	VERB
bibechana-68838	135	12	square	square	ADJ
bibechana-68838	135	13	deviation	deviation	NOUN
bibechana-68838	135	14	(	(	PUNCT
bibechana-68838	135	15	rmsd	rmsd	NOUN
bibechana-68838	135	16	)	)	PUNCT
bibechana-68838	135	17	of	of	ADP
bibechana-68838	135	18	the	the	DET
bibechana-68838	135	19	predicted	predict	VERB
bibechana-68838	135	20	kaiso	kaiso	NOUN
bibechana-68838	135	21	-	-	PUNCT
bibechana-68838	135	22	ctcf	ctcf	NOUN
bibechana-68838	135	23	complex	complex	NOUN
bibechana-68838	135	24	to	to	PART
bibechana-68838	135	25	assess	assess	VERB
bibechana-68838	135	26	the	the	DET
bibechana-68838	135	27	structural	structural	ADJ
bibechana-68838	135	28	integrity	integrity	NOUN
bibechana-68838	135	29	.	.	PUNCT
bibechana-68838	136	1	the	the	DET
bibechana-68838	136	2	time	time	NOUN
bibechana-68838	136	3	evolution	evolution	NOUN
bibechana-68838	136	4	of	of	ADP
bibechana-68838	136	5	the	the	DET
bibechana-68838	136	6	rmsd	rmsd	NOUN
bibechana-68838	136	7	of	of	ADP
bibechana-68838	136	8	the	the	DET
bibechana-68838	136	9	complex	complex	NOUN
bibechana-68838	136	10	was	be	AUX
bibechana-68838	136	11	calculated	calculate	VERB
bibechana-68838	136	12	using	use	VERB
bibechana-68838	136	13	the	the	DET
bibechana-68838	136	14	initial	initial	ADJ
bibechana-68838	136	15	frame	frame	NOUN
bibechana-68838	136	16	of	of	ADP
bibechana-68838	136	17	the	the	DET
bibechana-68838	136	18	simulation	simulation	NOUN
bibechana-68838	136	19	as	as	ADP
bibechana-68838	136	20	the	the	DET
bibechana-68838	136	21	reference	reference	NOUN
bibechana-68838	136	22	structure	structure	NOUN
bibechana-68838	136	23	.	.	PUNCT
bibechana-68838	137	1	the	the	DET
bibechana-68838	137	2	protein	protein	NOUN
bibechana-68838	137	3	backbone	backbone	NOUN
bibechana-68838	137	4	atoms	atom	NOUN
bibechana-68838	137	5	were	be	AUX
bibechana-68838	137	6	used	use	VERB
bibechana-68838	137	7	to	to	PART
bibechana-68838	137	8	calculate	calculate	VERB
bibechana-68838	137	9	the	the	DET
bibechana-68838	137	10	rmsd	rmsd	ADJ
bibechana-68838	137	11	values	value	NOUN
bibechana-68838	137	12	.	.	PUNCT
bibechana-68838	138	1	as	as	SCONJ
bibechana-68838	138	2	shown	show	VERB
bibechana-68838	138	3	in	in	ADP
bibechana-68838	138	4	the	the	DET
bibechana-68838	138	5	bidhya	bidhya	NOUN
bibechana-68838	138	6	thapa	thapa	PROPN
bibechana-68838	138	7	and	and	CCONJ
bibechana-68838	138	8	narayan	narayan	PROPN
bibechana-68838	138	9	prasad	prasad	PROPN
bibechana-68838	138	10	adhikari/	adhikari/	NUM
bibechana-68838	138	11	bibechana	bibechana	NOUN
bibechana-68838	138	12	21	21	NUM
bibechana-68838	138	13	(	(	PUNCT
bibechana-68838	138	14	2024	2024	NUM
bibechana-68838	138	15	)	)	PUNCT
bibechana-68838	138	16	290	290	NUM
bibechana-68838	138	17	-	-	SYM
bibechana-68838	138	18	299	299	NUM
bibechana-68838	138	19	294	294	NUM
bibechana-68838	138	20	rmsd	rmsd	NOUN
bibechana-68838	138	21	plot	plot	NOUN
bibechana-68838	138	22	in	in	ADP
bibechana-68838	138	23	figure	figure	NOUN
bibechana-68838	138	24	2b	2b	NOUN
bibechana-68838	138	25	,	,	PUNCT
bibechana-68838	138	26	the	the	DET
bibechana-68838	138	27	kaiso	kaiso	NOUN
bibechana-68838	138	28	-	-	PUNCT
bibechana-68838	138	29	ctcf	ctcf	ADJ
bibechana-68838	138	30	complex	complex	ADJ
bibechana-68838	138	31	undergoes	undergoe	NOUN
bibechana-68838	138	32	structural	structural	ADJ
bibechana-68838	138	33	reorganization	reorganization	NOUN
bibechana-68838	138	34	up	up	ADP
bibechana-68838	138	35	to	to	ADP
bibechana-68838	138	36	200	200	NUM
bibechana-68838	138	37	ns	ns	NUM
bibechana-68838	138	38	of	of	ADP
bibechana-68838	138	39	the	the	DET
bibechana-68838	138	40	simulation	simulation	NOUN
bibechana-68838	138	41	and	and	CCONJ
bibechana-68838	138	42	becomes	become	VERB
bibechana-68838	138	43	stable	stable	ADJ
bibechana-68838	138	44	.	.	PUNCT
bibechana-68838	139	1	the	the	DET
bibechana-68838	139	2	average	average	ADJ
bibechana-68838	139	3	rmsd	rmsd	NOUN
bibechana-68838	139	4	of	of	ADP
bibechana-68838	139	5	the	the	DET
bibechana-68838	139	6	complex	complex	ADJ
bibechana-68838	139	7	settles	settle	VERB
bibechana-68838	139	8	down	down	ADV
bibechana-68838	139	9	to	to	ADP
bibechana-68838	139	10	nearly	nearly	ADV
bibechana-68838	139	11	3.5	3.5	NUM
bibechana-68838	139	12	å	å	NOUN
bibechana-68838	139	13	.	.	PUNCT
bibechana-68838	140	1	individually	individually	ADV
bibechana-68838	140	2	,	,	PUNCT
bibechana-68838	140	3	the	the	DET
bibechana-68838	140	4	ctcf	ctcf	NOUN
bibechana-68838	140	5	shows	show	VERB
bibechana-68838	140	6	larger	large	ADJ
bibechana-68838	140	7	structural	structural	ADJ
bibechana-68838	140	8	variation	variation	NOUN
bibechana-68838	140	9	compared	compare	VERB
bibechana-68838	140	10	to	to	ADP
bibechana-68838	140	11	the	the	DET
bibechana-68838	140	12	btb	btb	NOUN
bibechana-68838	140	13	/	/	SYM
bibechana-68838	140	14	poz	poz	PROPN
bibechana-68838	140	15	domain	domain	NOUN
bibechana-68838	140	16	of	of	ADP
bibechana-68838	140	17	kaiso	kaiso	NOUN
bibechana-68838	140	18	,	,	PUNCT
bibechana-68838	140	19	owing	owe	VERB
bibechana-68838	140	20	to	to	ADP
bibechana-68838	140	21	its	its	PRON
bibechana-68838	140	22	flexible	flexible	ADJ
bibechana-68838	140	23	structure	structure	NOUN
bibechana-68838	140	24	compared	compare	VERB
bibechana-68838	140	25	to	to	ADP
bibechana-68838	140	26	the	the	DET
bibechana-68838	140	27	stable	stable	ADJ
bibechana-68838	140	28	btb	btb	NOUN
bibechana-68838	140	29	domain	domain	NOUN
bibechana-68838	140	30	of	of	ADP
bibechana-68838	140	31	kaiso	kaiso	NOUN
bibechana-68838	140	32	.	.	PUNCT
bibechana-68838	141	1	we	we	PRON
bibechana-68838	141	2	used	use	VERB
bibechana-68838	141	3	the	the	DET
bibechana-68838	141	4	md	md	PROPN
bibechana-68838	141	5	simulation	simulation	PROPN
bibechana-68838	141	6	trajectories	trajectory	NOUN
bibechana-68838	141	7	after	after	ADP
bibechana-68838	141	8	200ns	200ns	NOUN
bibechana-68838	141	9	,	,	PUNCT
bibechana-68838	141	10	where	where	SCONJ
bibechana-68838	141	11	the	the	DET
bibechana-68838	141	12	system	system	NOUN
bibechana-68838	141	13	is	be	AUX
bibechana-68838	141	14	properly	properly	ADV
bibechana-68838	141	15	stabilized	stabilize	VERB
bibechana-68838	141	16	,	,	PUNCT
bibechana-68838	141	17	to	to	PART
bibechana-68838	141	18	estimate	estimate	VERB
bibechana-68838	141	19	the	the	DET
bibechana-68838	141	20	average	average	ADJ
bibechana-68838	141	21	properties	property	NOUN
bibechana-68838	141	22	of	of	ADP
bibechana-68838	141	23	the	the	DET
bibechana-68838	141	24	system	system	NOUN
bibechana-68838	141	25	.	.	PUNCT
bibechana-68838	142	1	in	in	ADP
bibechana-68838	142	2	addition	addition	NOUN
bibechana-68838	142	3	,	,	PUNCT
bibechana-68838	142	4	to	to	PART
bibechana-68838	142	5	analyze	analyze	VERB
bibechana-68838	142	6	the	the	DET
bibechana-68838	142	7	flexibility	flexibility	NOUN
bibechana-68838	142	8	of	of	ADP
bibechana-68838	142	9	each	each	DET
bibechana-68838	142	10	residue	residue	NOUN
bibechana-68838	142	11	in	in	ADP
bibechana-68838	142	12	the	the	DET
bibechana-68838	142	13	complex	complex	NOUN
bibechana-68838	142	14	,	,	PUNCT
bibechana-68838	142	15	we	we	PRON
bibechana-68838	142	16	calculated	calculate	VERB
bibechana-68838	142	17	the	the	DET
bibechana-68838	142	18	root	root	NOUN
bibechana-68838	142	19	mean	mean	ADJ
bibechana-68838	142	20	square	square	ADJ
bibechana-68838	142	21	fluctuation	fluctuation	NOUN
bibechana-68838	142	22	(	(	PUNCT
bibechana-68838	142	23	rmsf	rmsf	NOUN
bibechana-68838	142	24	)	)	PUNCT
bibechana-68838	142	25	of	of	ADP
bibechana-68838	142	26	individual	individual	ADJ
bibechana-68838	142	27	residues	residue	NOUN
bibechana-68838	142	28	using	use	VERB
bibechana-68838	142	29	the	the	DET
bibechana-68838	142	30	backbone	backbone	NOUN
bibechana-68838	142	31	c	c	NOUN
bibechana-68838	142	32	atoms	atom	NOUN
bibechana-68838	142	33	.	.	PUNCT
bibechana-68838	143	1	as	as	SCONJ
bibechana-68838	143	2	shown	show	VERB
bibechana-68838	143	3	in	in	ADP
bibechana-68838	143	4	figures	figure	NOUN
bibechana-68838	143	5	2c	2c	NOUN
bibechana-68838	143	6	and	and	CCONJ
bibechana-68838	143	7	2d	2d	NOUN
bibechana-68838	143	8	,	,	PUNCT
bibechana-68838	143	9	the	the	DET
bibechana-68838	143	10	rmsf	rmsf	NOUN
bibechana-68838	143	11	of	of	ADP
bibechana-68838	143	12	kaiso	kaiso	NOUN
bibechana-68838	143	13	residues	residue	NOUN
bibechana-68838	143	14	is	be	AUX
bibechana-68838	143	15	significantly	significantly	ADV
bibechana-68838	143	16	stable	stable	ADJ
bibechana-68838	143	17	compared	compare	VERB
bibechana-68838	143	18	to	to	ADP
bibechana-68838	143	19	the	the	DET
bibechana-68838	143	20	residues	residue	NOUN
bibechana-68838	143	21	in	in	ADP
bibechana-68838	143	22	ctcf	ctcf	NOUN
bibechana-68838	143	23	.	.	PUNCT
bibechana-68838	144	1	as	as	SCONJ
bibechana-68838	144	2	expected	expect	VERB
bibechana-68838	144	3	,	,	PUNCT
bibechana-68838	144	4	the	the	DET
bibechana-68838	144	5	extremities	extremity	NOUN
bibechana-68838	144	6	of	of	ADP
bibechana-68838	144	7	both	both	DET
bibechana-68838	144	8	proteins	protein	NOUN
bibechana-68838	144	9	are	be	AUX
bibechana-68838	144	10	highly	highly	ADV
bibechana-68838	144	11	flexible	flexible	ADJ
bibechana-68838	144	12	due	due	ADP
bibechana-68838	144	13	to	to	ADP
bibechana-68838	144	14	a	a	DET
bibechana-68838	144	15	lack	lack	NOUN
bibechana-68838	144	16	of	of	ADP
bibechana-68838	144	17	interactions	interaction	NOUN
bibechana-68838	144	18	with	with	ADP
bibechana-68838	144	19	another	another	DET
bibechana-68838	144	20	protein	protein	NOUN
bibechana-68838	144	21	.	.	PUNCT
bibechana-68838	145	1	in	in	ADP
bibechana-68838	145	2	kaiso	kaiso	NOUN
bibechana-68838	145	3	,	,	PUNCT
bibechana-68838	145	4	except	except	SCONJ
bibechana-68838	145	5	for	for	ADP
bibechana-68838	145	6	the	the	DET
bibechana-68838	145	7	loop	loop	NOUN
bibechana-68838	145	8	containing	contain	VERB
bibechana-68838	145	9	residues	residue	NOUN
bibechana-68838	145	10	6266	6266	NUM
bibechana-68838	145	11	,	,	PUNCT
bibechana-68838	145	12	most	most	ADJ
bibechana-68838	145	13	residues	residue	NOUN
bibechana-68838	145	14	have	have	VERB
bibechana-68838	145	15	rmsf	rmsf	NOUN
bibechana-68838	145	16	of	of	ADP
bibechana-68838	145	17	less	less	ADJ
bibechana-68838	145	18	than	than	ADP
bibechana-68838	145	19	2	2	NUM
bibechana-68838	145	20	å	å	NOUN
bibechana-68838	145	21	.	.	PUNCT
bibechana-68838	146	1	in	in	ADP
bibechana-68838	146	2	ctcf	ctcf	PROPN
bibechana-68838	146	3	,	,	PUNCT
bibechana-68838	146	4	the	the	DET
bibechana-68838	146	5	residues	residue	NOUN
bibechana-68838	146	6	in	in	ADP
bibechana-68838	146	7	668	668	NUM
bibechana-68838	146	8	-	-	SYM
bibechana-68838	146	9	676	676	NUM
bibechana-68838	146	10	and	and	CCONJ
bibechana-68838	146	11	680	680	NUM
bibechana-68838	146	12	-	-	SYM
bibechana-68838	146	13	689	689	NUM
bibechana-68838	146	14	that	that	PRON
bibechana-68838	146	15	are	be	AUX
bibechana-68838	146	16	involved	involve	VERB
bibechana-68838	146	17	in	in	ADP
bibechana-68838	146	18	interaction	interaction	NOUN
bibechana-68838	146	19	with	with	ADP
bibechana-68838	146	20	kaiso	kaiso	NOUN
bibechana-68838	146	21	have	have	VERB
bibechana-68838	146	22	lower	low	ADJ
bibechana-68838	146	23	rmsf	rmsf	NOUN
bibechana-68838	146	24	,	,	PUNCT
bibechana-68838	146	25	indicating	indicate	VERB
bibechana-68838	146	26	higher	high	ADJ
bibechana-68838	146	27	stability	stability	NOUN
bibechana-68838	146	28	.	.	PUNCT
bibechana-68838	147	1	3.3	3.3	NUM
bibechana-68838	147	2	major	major	ADJ
bibechana-68838	147	3	interactions	interaction	NOUN
bibechana-68838	147	4	in	in	ADP
bibechana-68838	147	5	the	the	DET
bibechana-68838	147	6	kaiso	kaiso	NOUN
bibechana-68838	147	7	-	-	PUNCT
bibechana-68838	147	8	ctcf	ctcf	NOUN
bibechana-68838	147	9	complex	complex	NOUN
bibechana-68838	147	10	we	we	PRON
bibechana-68838	147	11	investigated	investigate	VERB
bibechana-68838	147	12	the	the	DET
bibechana-68838	147	13	various	various	ADJ
bibechana-68838	147	14	non	non	ADJ
bibechana-68838	147	15	-	-	ADJ
bibechana-68838	147	16	covalent	covalent	ADJ
bibechana-68838	147	17	interactions	interaction	NOUN
bibechana-68838	147	18	involved	involve	VERB
bibechana-68838	147	19	in	in	ADP
bibechana-68838	147	20	forming	form	VERB
bibechana-68838	147	21	and	and	CCONJ
bibechana-68838	147	22	stabilizing	stabilize	VERB
bibechana-68838	147	23	the	the	DET
bibechana-68838	147	24	complex	complex	NOUN
bibechana-68838	147	25	between	between	ADP
bibechana-68838	147	26	kaiso	kaiso	NOUN
bibechana-68838	147	27	and	and	CCONJ
bibechana-68838	147	28	ctcf	ctcf	NOUN
bibechana-68838	147	29	.	.	PUNCT
bibechana-68838	148	1	as	as	SCONJ
bibechana-68838	148	2	shown	show	VERB
bibechana-68838	148	3	in	in	ADP
bibechana-68838	148	4	figure	figure	NOUN
bibechana-68838	148	5	2a	2a	NUM
bibechana-68838	148	6	,	,	PUNCT
bibechana-68838	148	7	the	the	DET
bibechana-68838	148	8	kaiso	kaiso	NOUN
bibechana-68838	148	9	-	-	PUNCT
bibechana-68838	148	10	ctcf	ctcf	NOUN
bibechana-68838	148	11	complex	complex	NOUN
bibechana-68838	148	12	has	have	VERB
bibechana-68838	148	13	several	several	ADJ
bibechana-68838	148	14	hydrophobic	hydrophobic	NOUN
bibechana-68838	148	15	,	,	PUNCT
bibechana-68838	148	16	hydrogen	hydrogen	NOUN
bibechana-68838	148	17	bonding	bonding	NOUN
bibechana-68838	148	18	,	,	PUNCT
bibechana-68838	148	19	and	and	CCONJ
bibechana-68838	148	20	ionic	ionic	ADJ
bibechana-68838	148	21	interactions	interaction	NOUN
bibechana-68838	148	22	.	.	PUNCT
bibechana-68838	149	1	we	we	PRON
bibechana-68838	149	2	explored	explore	VERB
bibechana-68838	149	3	the	the	DET
bibechana-68838	149	4	detailed	detailed	ADJ
bibechana-68838	149	5	dynamics	dynamic	NOUN
bibechana-68838	149	6	of	of	ADP
bibechana-68838	149	7	these	these	DET
bibechana-68838	149	8	interactions	interaction	NOUN
bibechana-68838	149	9	during	during	ADP
bibechana-68838	149	10	the	the	DET
bibechana-68838	149	11	simulation	simulation	NOUN
bibechana-68838	149	12	.	.	PUNCT
bibechana-68838	150	1	hydrophobic	hydrophobic	NOUN
bibechana-68838	150	2	interactions	interaction	NOUN
bibechana-68838	150	3	the	the	DET
bibechana-68838	150	4	btb	btb	NOUN
bibechana-68838	150	5	/	/	SYM
bibechana-68838	150	6	poz	poz	PROPN
bibechana-68838	150	7	domain	domain	NOUN
bibechana-68838	150	8	of	of	ADP
bibechana-68838	150	9	kaiso	kaiso	NOUN
bibechana-68838	150	10	and	and	CCONJ
bibechana-68838	150	11	the	the	DET
bibechana-68838	150	12	-sheet	-sheet	NOUN
bibechana-68838	150	13	in	in	ADP
bibechana-68838	150	14	the	the	DET
bibechana-68838	150	15	binding	bind	VERB
bibechana-68838	150	16	site	site	NOUN
bibechana-68838	150	17	of	of	ADP
bibechana-68838	150	18	ctcf	ctcf	PROPN
bibechana-68838	150	19	contain	contain	VERB
bibechana-68838	150	20	multiple	multiple	ADJ
bibechana-68838	150	21	hydrophobic	hydrophobic	NOUN
bibechana-68838	150	22	residues	residue	NOUN
bibechana-68838	150	23	.	.	PUNCT
bibechana-68838	151	1	therefore	therefore	ADV
bibechana-68838	151	2	,	,	PUNCT
bibechana-68838	151	3	several	several	ADJ
bibechana-68838	151	4	inter	inter	ADJ
bibechana-68838	151	5	-	-	ADJ
bibechana-68838	151	6	protein	protein	ADJ
bibechana-68838	151	7	hydrophobic	hydrophobic	NOUN
bibechana-68838	151	8	interactions	interaction	NOUN
bibechana-68838	151	9	are	be	AUX
bibechana-68838	151	10	present	present	ADJ
bibechana-68838	151	11	at	at	ADP
bibechana-68838	151	12	the	the	DET
bibechana-68838	151	13	binding	bind	VERB
bibechana-68838	151	14	interface	interface	NOUN
bibechana-68838	151	15	of	of	ADP
bibechana-68838	151	16	the	the	DET
bibechana-68838	151	17	kaiso	kaiso	NOUN
bibechana-68838	151	18	-	-	PUNCT
bibechana-68838	151	19	ctcf	ctcf	NOUN
bibechana-68838	151	20	complex	complex	NOUN
bibechana-68838	151	21	.	.	PUNCT
bibechana-68838	152	1	figure	figure	NOUN
bibechana-68838	152	2	3a	3a	PROPN
bibechana-68838	152	3	shows	show	VERB
bibechana-68838	152	4	the	the	DET
bibechana-68838	152	5	representative	representative	ADJ
bibechana-68838	152	6	snapshot	snapshot	NOUN
bibechana-68838	152	7	of	of	ADP
bibechana-68838	152	8	the	the	DET
bibechana-68838	152	9	md	md	PROPN
bibechana-68838	152	10	simulation	simulation	NOUN
bibechana-68838	152	11	showing	show	VERB
bibechana-68838	152	12	the	the	DET
bibechana-68838	152	13	hydrophobic	hydrophobic	NOUN
bibechana-68838	152	14	interactions	interaction	NOUN
bibechana-68838	152	15	in	in	ADP
bibechana-68838	152	16	the	the	DET
bibechana-68838	152	17	kaiso	kaiso	NOUN
bibechana-68838	152	18	-	-	PUNCT
bibechana-68838	152	19	ctcf	ctcf	NOUN
bibechana-68838	152	20	.	.	PUNCT
bibechana-68838	153	1	our	our	PRON
bibechana-68838	153	2	results	result	NOUN
bibechana-68838	153	3	predict	predict	VERB
bibechana-68838	153	4	that	that	SCONJ
bibechana-68838	153	5	the	the	DET
bibechana-68838	153	6	val673	val673	PROPN
bibechana-68838	153	7	and	and	CCONJ
bibechana-68838	153	8	ile684	ile684	PROPN
bibechana-68838	153	9	in	in	ADP
bibechana-68838	153	10	ctcf	ctcf	NOUN
bibechana-68838	153	11	make	make	VERB
bibechana-68838	153	12	hydrophobic	hydrophobic	NOUN
bibechana-68838	153	13	interactions	interaction	NOUN
bibechana-68838	153	14	with	with	ADP
bibechana-68838	153	15	val93	val93	ADJ
bibechana-68838	153	16	and	and	CCONJ
bibechana-68838	153	17	leu98	leu98	NOUN
bibechana-68838	153	18	of	of	ADP
bibechana-68838	153	19	kaiso	kaiso	NOUN
bibechana-68838	153	20	.	.	PUNCT
bibechana-68838	154	1	similarly	similarly	ADV
bibechana-68838	154	2	,	,	PUNCT
bibechana-68838	154	3	ile90	ile90	PROPN
bibechana-68838	154	4	,	,	PUNCT
bibechana-68838	154	5	leu101	leu101	PROPN
bibechana-68838	154	6	,	,	PUNCT
bibechana-68838	154	7	and	and	CCONJ
bibechana-68838	154	8	ile102	ile102	PROPN
bibechana-68838	154	9	in	in	ADP
bibechana-68838	154	10	kaiso	kaiso	NOUN
bibechana-68838	154	11	create	create	VERB
bibechana-68838	154	12	hydrophobic	hydrophobic	NOUN
bibechana-68838	154	13	grooves	groove	NOUN
bibechana-68838	154	14	with	with	ADP
bibechana-68838	154	15	val686	val686	PROPN
bibechana-68838	154	16	,	,	PUNCT
bibechana-68838	154	17	ile671	ile671	PROPN
bibechana-68838	154	18	,	,	PUNCT
bibechana-68838	154	19	and	and	CCONJ
bibechana-68838	154	20	ala669	ala669	PROPN
bibechana-68838	154	21	in	in	ADP
bibechana-68838	154	22	ctcf	ctcf	PROPN
bibechana-68838	154	23	.	.	PUNCT
bibechana-68838	155	1	in	in	ADP
bibechana-68838	155	2	addition	addition	NOUN
bibechana-68838	155	3	,	,	PUNCT
bibechana-68838	155	4	ile113	ile113	NOUN
bibechana-68838	155	5	and	and	CCONJ
bibechana-68838	155	6	leu116	leu116	PROPN
bibechana-68838	155	7	of	of	ADP
bibechana-68838	155	8	kasio	kasio	NOUN
bibechana-68838	155	9	interact	interact	VERB
bibechana-68838	155	10	with	with	ADP
bibechana-68838	155	11	ala669	ala669	PROPN
bibechana-68838	155	12	of	of	ADP
bibechana-68838	155	13	ctcf	ctcf	PROPN
bibechana-68838	155	14	.	.	PUNCT
bibechana-68838	156	1	moreover	moreover	ADV
bibechana-68838	156	2	,	,	PUNCT
bibechana-68838	156	3	phe112	phe112	PROPN
bibechana-68838	156	4	in	in	ADP
bibechana-68838	156	5	kaiso	kaiso	NOUN
bibechana-68838	156	6	makes	make	VERB
bibechana-68838	156	7	hydrophobic	hydrophobic	NOUN
bibechana-68838	156	8	contact	contact	NOUN
bibechana-68838	156	9	with	with	ADP
bibechana-68838	156	10	pro667	pro667	PROPN
bibechana-68838	156	11	and	and	CCONJ
bibechana-68838	156	12	val668	val668	NOUN
bibechana-68838	156	13	in	in	ADP
bibechana-68838	156	14	ctcf	ctcf	PROPN
bibechana-68838	156	15	.	.	PUNCT
bibechana-68838	157	1	figure	figure	VERB
bibechana-68838	157	2	2	2	NUM
bibechana-68838	157	3	:	:	PUNCT
bibechana-68838	157	4	(	(	PUNCT
bibechana-68838	157	5	a	a	X
bibechana-68838	157	6	)	)	PUNCT
bibechana-68838	157	7	kasio	kasio	NOUN
bibechana-68838	157	8	-	-	PUNCT
bibechana-68838	157	9	ctcf	ctcf	PROPN
bibechana-68838	157	10	complex	complex	NOUN
bibechana-68838	157	11	at	at	ADP
bibechana-68838	157	12	the	the	DET
bibechana-68838	157	13	end	end	NOUN
bibechana-68838	157	14	of	of	ADP
bibechana-68838	157	15	350	350	NUM
bibechana-68838	157	16	ns	ns	NUM
bibechana-68838	157	17	md	md	PROPN
bibechana-68838	157	18	simulation	simulation	NOUN
bibechana-68838	157	19	.	.	PUNCT
bibechana-68838	158	1	(	(	PUNCT
bibechana-68838	158	2	b	b	X
bibechana-68838	158	3	)	)	PUNCT
bibechana-68838	158	4	time	time	NOUN
bibechana-68838	158	5	evolution	evolution	NOUN
bibechana-68838	158	6	of	of	ADP
bibechana-68838	158	7	the	the	DET
bibechana-68838	158	8	rmsd	rmsd	ADJ
bibechana-68838	158	9	measurement	measurement	NOUN
bibechana-68838	158	10	of	of	ADP
bibechana-68838	158	11	the	the	DET
bibechana-68838	158	12	kaiso	kaiso	NOUN
bibechana-68838	158	13	-	-	PUNCT
bibechana-68838	158	14	ctcf	ctcf	NOUN
bibechana-68838	158	15	complex	complex	NOUN
bibechana-68838	158	16	.	.	PUNCT
bibechana-68838	159	1	rmsf	rmsf	NOUN
bibechana-68838	159	2	measurements	measurement	NOUN
bibechana-68838	159	3	of	of	ADP
bibechana-68838	159	4	the	the	DET
bibechana-68838	159	5	(	(	PUNCT
bibechana-68838	159	6	c	c	NOUN
bibechana-68838	159	7	)	)	PUNCT
bibechana-68838	159	8	ctcf	ctcf	NOUN
bibechana-68838	160	1	and	and	CCONJ
bibechana-68838	160	2	(	(	PUNCT
bibechana-68838	160	3	d	d	NOUN
bibechana-68838	160	4	)	)	PUNCT
bibechana-68838	160	5	ctcf	ctcf	ADJ
bibechana-68838	160	6	residues	residue	NOUN
bibechana-68838	160	7	in	in	ADP
bibechana-68838	160	8	the	the	DET
bibechana-68838	160	9	kaiso	kaiso	NOUN
bibechana-68838	160	10	-	-	PUNCT
bibechana-68838	160	11	ctcf	ctcf	NOUN
bibechana-68838	160	12	complex	complex	NOUN
bibechana-68838	160	13	during	during	ADP
bibechana-68838	160	14	simulation	simulation	NOUN
bibechana-68838	160	15	.	.	PUNCT
bibechana-68838	161	1	bidhya	bidhya	PROPN
bibechana-68838	161	2	thapa	thapa	PROPN
bibechana-68838	161	3	and	and	CCONJ
bibechana-68838	161	4	narayan	narayan	PROPN
bibechana-68838	161	5	prasad	prasad	PROPN
bibechana-68838	161	6	adhikari/	adhikari/	NUM
bibechana-68838	161	7	bibechana	bibechana	NOUN
bibechana-68838	161	8	21	21	NUM
bibechana-68838	161	9	(	(	PUNCT
bibechana-68838	161	10	2024	2024	NUM
bibechana-68838	161	11	)	)	PUNCT
bibechana-68838	161	12	290	290	NUM
bibechana-68838	161	13	-	-	SYM
bibechana-68838	161	14	299	299	NUM
bibechana-68838	161	15	295	295	NUM
bibechana-68838	161	16	figure	figure	NOUN
bibechana-68838	161	17	3	3	NUM
bibechana-68838	161	18	:	:	PUNCT
bibechana-68838	161	19	(	(	PUNCT
bibechana-68838	161	20	a	a	X
bibechana-68838	161	21	)	)	PUNCT
bibechana-68838	161	22	representative	representative	ADJ
bibechana-68838	161	23	structure	structure	NOUN
bibechana-68838	161	24	of	of	ADP
bibechana-68838	161	25	the	the	DET
bibechana-68838	161	26	kasio	kasio	PROPN
bibechana-68838	161	27	-	-	PUNCT
bibechana-68838	161	28	ctcf	ctcf	PROPN
bibechana-68838	161	29	complex	complex	NOUN
bibechana-68838	161	30	during	during	ADP
bibechana-68838	161	31	the	the	DET
bibechana-68838	161	32	simulation	simulation	NOUN
bibechana-68838	161	33	highlighting	highlight	VERB
bibechana-68838	161	34	the	the	DET
bibechana-68838	161	35	hydrophobic	hydrophobic	NOUN
bibechana-68838	161	36	interactions	interaction	NOUN
bibechana-68838	161	37	at	at	ADP
bibechana-68838	161	38	the	the	DET
bibechana-68838	161	39	binding	bind	VERB
bibechana-68838	161	40	interface	interface	NOUN
bibechana-68838	161	41	.	.	PUNCT
bibechana-68838	162	1	(	(	PUNCT
bibechana-68838	162	2	b	b	X
bibechana-68838	162	3	)	)	PUNCT
bibechana-68838	162	4	time	time	NOUN
bibechana-68838	162	5	evolution	evolution	NOUN
bibechana-68838	162	6	of	of	ADP
bibechana-68838	162	7	the	the	DET
bibechana-68838	162	8	hydrophobic	hydrophobic	NOUN
bibechana-68838	162	9	contact	contact	NOUN
bibechana-68838	162	10	area	area	NOUN
bibechana-68838	162	11	between	between	ADP
bibechana-68838	162	12	the	the	DET
bibechana-68838	162	13	kaiso	kaiso	NOUN
bibechana-68838	162	14	and	and	CCONJ
bibechana-68838	162	15	ctcf	ctcf	VERB
bibechana-68838	162	16	during	during	ADP
bibechana-68838	162	17	the	the	DET
bibechana-68838	162	18	simulation	simulation	NOUN
bibechana-68838	162	19	.	.	PUNCT
bibechana-68838	163	1	we	we	PRON
bibechana-68838	163	2	calculated	calculate	VERB
bibechana-68838	163	3	the	the	DET
bibechana-68838	163	4	hydrophobic	hydrophobic	NOUN
bibechana-68838	163	5	contact	contact	NOUN
bibechana-68838	163	6	area	area	NOUN
bibechana-68838	163	7	between	between	ADP
bibechana-68838	163	8	kaiso	kaiso	NOUN
bibechana-68838	163	9	and	and	CCONJ
bibechana-68838	163	10	ctcf	ctcf	NOUN
bibechana-68838	163	11	to	to	PART
bibechana-68838	163	12	estimate	estimate	VERB
bibechana-68838	163	13	the	the	DET
bibechana-68838	163	14	contribution	contribution	NOUN
bibechana-68838	163	15	of	of	ADP
bibechana-68838	163	16	the	the	DET
bibechana-68838	163	17	hydrophobic	hydrophobic	NOUN
bibechana-68838	163	18	interactions	interaction	NOUN
bibechana-68838	163	19	to	to	ADP
bibechana-68838	163	20	the	the	DET
bibechana-68838	163	21	stability	stability	NOUN
bibechana-68838	163	22	of	of	ADP
bibechana-68838	163	23	the	the	DET
bibechana-68838	163	24	complex	complex	NOUN
bibechana-68838	163	25	.	.	PUNCT
bibechana-68838	164	1	the	the	DET
bibechana-68838	164	2	hydrophobic	hydrophobic	NOUN
bibechana-68838	164	3	contact	contact	NOUN
bibechana-68838	164	4	area	area	NOUN
bibechana-68838	164	5	is	be	AUX
bibechana-68838	164	6	the	the	DET
bibechana-68838	164	7	hydrophobic	hydrophobic	NOUN
bibechana-68838	164	8	surface	surface	NOUN
bibechana-68838	164	9	buried	bury	VERB
bibechana-68838	164	10	at	at	ADP
bibechana-68838	164	11	the	the	DET
bibechana-68838	164	12	binding	bind	VERB
bibechana-68838	164	13	interface	interface	NOUN
bibechana-68838	164	14	between	between	ADP
bibechana-68838	164	15	two	two	NUM
bibechana-68838	164	16	proteins	protein	NOUN
bibechana-68838	164	17	upon	upon	SCONJ
bibechana-68838	164	18	complex	complex	ADJ
bibechana-68838	164	19	formation	formation	NOUN
bibechana-68838	164	20	.	.	PUNCT
bibechana-68838	165	1	the	the	PRON
bibechana-68838	165	2	higher	high	ADJ
bibechana-68838	165	3	the	the	DET
bibechana-68838	165	4	contact	contact	NOUN
bibechana-68838	165	5	area	area	NOUN
bibechana-68838	165	6	,	,	PUNCT
bibechana-68838	165	7	the	the	PRON
bibechana-68838	165	8	greater	great	ADJ
bibechana-68838	165	9	the	the	DET
bibechana-68838	165	10	interacting	interact	VERB
bibechana-68838	165	11	surface	surface	NOUN
bibechana-68838	165	12	between	between	ADP
bibechana-68838	165	13	the	the	DET
bibechana-68838	165	14	interacting	interact	VERB
bibechana-68838	165	15	partners	partner	NOUN
bibechana-68838	165	16	,	,	PUNCT
bibechana-68838	165	17	which	which	PRON
bibechana-68838	165	18	leads	lead	VERB
bibechana-68838	165	19	to	to	ADP
bibechana-68838	165	20	the	the	DET
bibechana-68838	165	21	greater	great	ADJ
bibechana-68838	165	22	stability	stability	NOUN
bibechana-68838	165	23	of	of	ADP
bibechana-68838	165	24	the	the	DET
bibechana-68838	165	25	complex	complex	NOUN
bibechana-68838	165	26	[	[	X
bibechana-68838	165	27	39	39	NUM
bibechana-68838	165	28	]	]	PUNCT
bibechana-68838	165	29	.	.	PUNCT
bibechana-68838	166	1	we	we	PRON
bibechana-68838	166	2	calculated	calculate	VERB
bibechana-68838	166	3	the	the	DET
bibechana-68838	166	4	contact	contact	NOUN
bibechana-68838	166	5	area	area	NOUN
bibechana-68838	166	6	from	from	ADP
bibechana-68838	166	7	the	the	DET
bibechana-68838	166	8	sasa	sasa	NOUN
bibechana-68838	166	9	of	of	ADP
bibechana-68838	166	10	individual	individual	ADJ
bibechana-68838	166	11	proteins	protein	NOUN
bibechana-68838	166	12	and	and	CCONJ
bibechana-68838	166	13	complex	complex	ADJ
bibechana-68838	166	14	using	use	VERB
bibechana-68838	166	15	the	the	DET
bibechana-68838	166	16	following	follow	VERB
bibechana-68838	166	17	equation	equation	NOUN
bibechana-68838	166	18	[	[	X
bibechana-68838	166	19	39	39	NUM
bibechana-68838	166	20	]	]	PUNCT
bibechana-68838	166	21	.	.	PUNCT
bibechana-68838	167	1	contact	contact	NOUN
bibechana-68838	167	2	area	area	NOUN
bibechana-68838	167	3	=	=	SYM
bibechana-68838	167	4	(	(	PUNCT
bibechana-68838	167	5	skaiso+sctcf−scomplex	skaiso+sctcf−scomplex	NOUN
bibechana-68838	167	6	)	)	PUNCT
bibechana-68838	167	7	2	2	NUM
bibechana-68838	167	8	where	where	SCONJ
bibechana-68838	167	9	skaiso	skaiso	NOUN
bibechana-68838	167	10	,	,	PUNCT
bibechana-68838	167	11	sctcf	sctcf	NOUN
bibechana-68838	167	12	,	,	PUNCT
bibechana-68838	167	13	and	and	CCONJ
bibechana-68838	167	14	scomplex	scomplex	NOUN
bibechana-68838	167	15	are	be	AUX
bibechana-68838	167	16	the	the	DET
bibechana-68838	167	17	hydrophobic	hydrophobic	NOUN
bibechana-68838	167	18	sasa	sasa	NOUN
bibechana-68838	167	19	of	of	ADP
bibechana-68838	167	20	the	the	DET
bibechana-68838	167	21	kaiso	kaiso	NOUN
bibechana-68838	167	22	,	,	PUNCT
bibechana-68838	167	23	ctcf	ctcf	ADJ
bibechana-68838	167	24	,	,	PUNCT
bibechana-68838	167	25	and	and	CCONJ
bibechana-68838	167	26	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	167	27	complex	complex	PROPN
bibechana-68838	167	28	.	.	PUNCT
bibechana-68838	168	1	figure	figure	NOUN
bibechana-68838	168	2	3b	3b	NOUN
bibechana-68838	168	3	shows	show	VERB
bibechana-68838	168	4	the	the	DET
bibechana-68838	168	5	time	time	NOUN
bibechana-68838	168	6	evolution	evolution	NOUN
bibechana-68838	168	7	of	of	ADP
bibechana-68838	168	8	the	the	DET
bibechana-68838	168	9	hydrophobic	hydrophobic	NOUN
bibechana-68838	168	10	contact	contact	NOUN
bibechana-68838	168	11	area	area	NOUN
bibechana-68838	168	12	between	between	ADP
bibechana-68838	168	13	the	the	DET
bibechana-68838	168	14	kaiso	kaiso	NOUN
bibechana-68838	168	15	and	and	CCONJ
bibechana-68838	168	16	ctcf	ctcf	NOUN
bibechana-68838	168	17	.	.	PUNCT
bibechana-68838	169	1	the	the	DET
bibechana-68838	169	2	average	average	ADJ
bibechana-68838	169	3	hydrophobic	hydrophobic	NOUN
bibechana-68838	169	4	contact	contact	NOUN
bibechana-68838	169	5	area	area	NOUN
bibechana-68838	169	6	for	for	ADP
bibechana-68838	169	7	the	the	DET
bibechana-68838	169	8	last	last	ADJ
bibechana-68838	169	9	150	150	NUM
bibechana-68838	169	10	ns	ns	NUM
bibechana-68838	169	11	of	of	ADP
bibechana-68838	169	12	the	the	DET
bibechana-68838	169	13	simulation	simulation	NOUN
bibechana-68838	169	14	trajectories	trajectory	NOUN
bibechana-68838	169	15	is	be	AUX
bibechana-68838	169	16	365	365	NUM
bibechana-68838	169	17	±	±	NUM
bibechana-68838	169	18	54	54	NUM
bibechana-68838	169	19	å2	å2	NOUN
bibechana-68838	169	20	.	.	PUNCT
bibechana-68838	170	1	previous	previous	ADJ
bibechana-68838	170	2	studies	study	NOUN
bibechana-68838	170	3	have	have	AUX
bibechana-68838	170	4	shown	show	VERB
bibechana-68838	170	5	that	that	SCONJ
bibechana-68838	170	6	the	the	DET
bibechana-68838	170	7	burial	burial	NOUN
bibechana-68838	170	8	of	of	ADP
bibechana-68838	170	9	1	1	NUM
bibechana-68838	170	10	å2	å2	NOUN
bibechana-68838	170	11	of	of	ADP
bibechana-68838	170	12	hydrophobic	hydrophobic	NOUN
bibechana-68838	170	13	surface	surface	NOUN
bibechana-68838	170	14	area	area	NOUN
bibechana-68838	170	15	at	at	ADP
bibechana-68838	170	16	the	the	DET
bibechana-68838	170	17	binding	bind	VERB
bibechana-68838	170	18	interface	interface	NOUN
bibechana-68838	170	19	contributes	contribute	VERB
bibechana-68838	170	20	about	about	ADP
bibechana-68838	170	21	-15	-15	SYM
bibechana-68838	170	22	±	±	NUM
bibechana-68838	170	23	1.2	1.2	NUM
bibechana-68838	170	24	cal	cal	NOUN
bibechana-68838	170	25	/	/	SYM
bibechana-68838	170	26	mol	mol	ADP
bibechana-68838	171	1	[	[	X
bibechana-68838	171	2	39	39	NUM
bibechana-68838	171	3	,	,	PUNCT
bibechana-68838	171	4	40	40	NUM
bibechana-68838	171	5	]	]	PUNCT
bibechana-68838	171	6	of	of	ADP
bibechana-68838	171	7	free	free	ADJ
bibechana-68838	171	8	energy	energy	NOUN
bibechana-68838	171	9	to	to	PART
bibechana-68838	171	10	stabilize	stabilize	VERB
bibechana-68838	171	11	the	the	DET
bibechana-68838	171	12	complex	complex	NOUN
bibechana-68838	171	13	.	.	PUNCT
bibechana-68838	172	1	therefore	therefore	ADV
bibechana-68838	172	2	,	,	PUNCT
bibechana-68838	172	3	the	the	DET
bibechana-68838	172	4	365	365	NUM
bibechana-68838	172	5	å2	å2	NOUN
bibechana-68838	172	6	of	of	ADP
bibechana-68838	172	7	the	the	DET
bibechana-68838	172	8	hydrophobic	hydrophobic	NOUN
bibechana-68838	172	9	contact	contact	NOUN
bibechana-68838	172	10	area	area	NOUN
bibechana-68838	172	11	of	of	ADP
bibechana-68838	172	12	the	the	DET
bibechana-68838	172	13	kaiso	kaiso	NOUN
bibechana-68838	172	14	-	-	PUNCT
bibechana-68838	172	15	ctcf	ctcf	NOUN
bibechana-68838	172	16	complex	complex	NOUN
bibechana-68838	172	17	contributes	contribute	VERB
bibechana-68838	172	18	about	about	ADP
bibechana-68838	172	19	-5.5	-5.5	PUNCT
bibechana-68838	172	20	kcal	kcal	NOUN
bibechana-68838	172	21	/	/	SYM
bibechana-68838	172	22	mol	mol	NOUN
bibechana-68838	172	23	to	to	ADP
bibechana-68838	172	24	its	its	PRON
bibechana-68838	172	25	stability	stability	NOUN
bibechana-68838	172	26	.	.	PUNCT
bibechana-68838	173	1	therefore	therefore	ADV
bibechana-68838	173	2	,	,	PUNCT
bibechana-68838	173	3	hydrophobic	hydrophobic	NOUN
bibechana-68838	173	4	interactions	interaction	NOUN
bibechana-68838	173	5	are	be	AUX
bibechana-68838	173	6	crucial	crucial	ADJ
bibechana-68838	173	7	in	in	ADP
bibechana-68838	173	8	the	the	DET
bibechana-68838	173	9	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	173	10	complex	complex	ADJ
bibechana-68838	173	11	formation	formation	NOUN
bibechana-68838	173	12	and	and	CCONJ
bibechana-68838	173	13	stabilization	stabilization	NOUN
bibechana-68838	173	14	.	.	PUNCT
bibechana-68838	174	1	hydrogen	hydrogen	NOUN
bibechana-68838	174	2	bonds	bond	NOUN
bibechana-68838	174	3	interactions	interaction	NOUN
bibechana-68838	174	4	we	we	PRON
bibechana-68838	174	5	analyzed	analyze	VERB
bibechana-68838	174	6	the	the	DET
bibechana-68838	174	7	inter	inter	ADJ
bibechana-68838	174	8	-	-	ADJ
bibechana-68838	174	9	protein	protein	ADJ
bibechana-68838	174	10	hydrogen	hydrogen	NOUN
bibechana-68838	174	11	bond	bond	NOUN
bibechana-68838	174	12	interactions	interaction	NOUN
bibechana-68838	174	13	between	between	ADP
bibechana-68838	174	14	the	the	DET
bibechana-68838	174	15	kaiso	kaiso	NOUN
bibechana-68838	174	16	and	and	CCONJ
bibechana-68838	174	17	ctcf	ctcf	NOUN
bibechana-68838	174	18	using	use	VERB
bibechana-68838	174	19	the	the	DET
bibechana-68838	174	20	criterion	criterion	NOUN
bibechana-68838	174	21	explained	explain	VERB
bibechana-68838	174	22	in	in	ADP
bibechana-68838	174	23	the	the	DET
bibechana-68838	174	24	methods	method	NOUN
bibechana-68838	174	25	section	section	NOUN
bibechana-68838	174	26	.	.	PUNCT
bibechana-68838	175	1	the	the	DET
bibechana-68838	175	2	time	time	NOUN
bibechana-68838	175	3	evolution	evolution	NOUN
bibechana-68838	175	4	of	of	ADP
bibechana-68838	175	5	the	the	DET
bibechana-68838	175	6	total	total	ADJ
bibechana-68838	175	7	number	number	NOUN
bibechana-68838	175	8	of	of	ADP
bibechana-68838	175	9	hydrogen	hydrogen	NOUN
bibechana-68838	175	10	bonds	bond	NOUN
bibechana-68838	175	11	between	between	ADP
bibechana-68838	175	12	inter	inter	ADJ
bibechana-68838	175	13	-	-	ADJ
bibechana-68838	175	14	facial	facial	ADJ
bibechana-68838	175	15	residues	residue	NOUN
bibechana-68838	175	16	in	in	ADP
bibechana-68838	175	17	the	the	DET
bibechana-68838	175	18	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	175	19	complex	complex	NOUN
bibechana-68838	175	20	is	be	AUX
bibechana-68838	175	21	shown	show	VERB
bibechana-68838	175	22	in	in	ADP
bibechana-68838	175	23	figure	figure	NOUN
bibechana-68838	175	24	4a	4a	NUM
bibechana-68838	175	25	.	.	PUNCT
bibechana-68838	176	1	as	as	SCONJ
bibechana-68838	176	2	the	the	DET
bibechana-68838	176	3	complex	complex	ADJ
bibechana-68838	176	4	undergoes	undergo	VERB
bibechana-68838	176	5	structural	structural	ADJ
bibechana-68838	176	6	reorganization	reorganization	NOUN
bibechana-68838	176	7	till	till	SCONJ
bibechana-68838	176	8	200	200	NUM
bibechana-68838	176	9	ns	ns	NUM
bibechana-68838	176	10	and	and	CCONJ
bibechana-68838	176	11	becomes	become	VERB
bibechana-68838	176	12	stable	stable	ADJ
bibechana-68838	176	13	,	,	PUNCT
bibechana-68838	176	14	we	we	PRON
bibechana-68838	176	15	used	use	VERB
bibechana-68838	176	16	the	the	DET
bibechana-68838	176	17	simulation	simulation	NOUN
bibechana-68838	176	18	trajectory	trajectory	NOUN
bibechana-68838	176	19	of	of	ADP
bibechana-68838	176	20	200	200	NUM
bibechana-68838	176	21	-	-	SYM
bibechana-68838	176	22	350	350	NUM
bibechana-68838	176	23	ns	ns	NUM
bibechana-68838	176	24	to	to	PART
bibechana-68838	176	25	estimate	estimate	VERB
bibechana-68838	176	26	the	the	DET
bibechana-68838	176	27	occupancy	occupancy	NOUN
bibechana-68838	176	28	percentage	percentage	NOUN
bibechana-68838	176	29	of	of	ADP
bibechana-68838	176	30	the	the	DET
bibechana-68838	176	31	hydrogen	hydrogen	NOUN
bibechana-68838	176	32	bonds	bond	NOUN
bibechana-68838	176	33	.	.	PUNCT
bibechana-68838	177	1	figure	figure	VERB
bibechana-68838	177	2	4b	4b	PROPN
bibechana-68838	177	3	shows	show	VERB
bibechana-68838	177	4	the	the	DET
bibechana-68838	177	5	occupancy	occupancy	NOUN
bibechana-68838	177	6	percentage	percentage	NOUN
bibechana-68838	177	7	of	of	ADP
bibechana-68838	177	8	major	major	ADJ
bibechana-68838	177	9	hydrogen	hydrogen	NOUN
bibechana-68838	177	10	bonds	bond	NOUN
bibechana-68838	177	11	involved	involve	VERB
bibechana-68838	177	12	in	in	ADP
bibechana-68838	177	13	forming	form	VERB
bibechana-68838	177	14	the	the	DET
bibechana-68838	177	15	kaiso	kaiso	NOUN
bibechana-68838	177	16	-	-	PUNCT
bibechana-68838	177	17	ctcf	ctcf	NOUN
bibechana-68838	177	18	complex	complex	NOUN
bibechana-68838	177	19	.	.	PUNCT
bibechana-68838	178	1	as	as	SCONJ
bibechana-68838	178	2	more	more	ADJ
bibechana-68838	178	3	than	than	ADP
bibechana-68838	178	4	one	one	NUM
bibechana-68838	178	5	pair	pair	NOUN
bibechana-68838	178	6	of	of	ADP
bibechana-68838	178	7	atoms	atom	NOUN
bibechana-68838	178	8	are	be	AUX
bibechana-68838	178	9	involved	involve	VERB
bibechana-68838	178	10	in	in	ADP
bibechana-68838	178	11	forming	form	VERB
bibechana-68838	178	12	hydrogen	hydrogen	NOUN
bibechana-68838	178	13	bonds	bond	NOUN
bibechana-68838	178	14	in	in	ADP
bibechana-68838	178	15	a	a	DET
bibechana-68838	178	16	given	give	VERB
bibechana-68838	178	17	residue	residue	NOUN
bibechana-68838	178	18	pair	pair	NOUN
bibechana-68838	178	19	,	,	PUNCT
bibechana-68838	178	20	the	the	DET
bibechana-68838	178	21	occupancy	occupancy	NOUN
bibechana-68838	178	22	percentage	percentage	NOUN
bibechana-68838	178	23	included	include	VERB
bibechana-68838	178	24	in	in	ADP
bibechana-68838	178	25	figure	figure	NOUN
bibechana-68838	178	26	4b	4b	PROPN
bibechana-68838	178	27	is	be	AUX
bibechana-68838	178	28	the	the	DET
bibechana-68838	178	29	aggregation	aggregation	NOUN
bibechana-68838	178	30	of	of	ADP
bibechana-68838	178	31	all	all	DET
bibechana-68838	178	32	hydrogen	hydrogen	NOUN
bibechana-68838	178	33	bonds	bond	NOUN
bibechana-68838	178	34	formed	form	VERB
bibechana-68838	178	35	within	within	ADP
bibechana-68838	178	36	a	a	DET
bibechana-68838	178	37	given	give	VERB
bibechana-68838	178	38	residue	residue	NOUN
bibechana-68838	178	39	pair	pair	NOUN
bibechana-68838	178	40	.	.	PUNCT
bibechana-68838	179	1	figure	figure	NOUN
bibechana-68838	179	2	4c	4c	NOUN
bibechana-68838	179	3	shows	show	VERB
bibechana-68838	179	4	the	the	DET
bibechana-68838	179	5	atomic	atomic	ADJ
bibechana-68838	179	6	details	detail	NOUN
bibechana-68838	179	7	of	of	ADP
bibechana-68838	179	8	the	the	DET
bibechana-68838	179	9	significant	significant	ADJ
bibechana-68838	179	10	inter	inter	ADJ
bibechana-68838	179	11	-	-	ADJ
bibechana-68838	179	12	protein	protein	ADJ
bibechana-68838	179	13	hydrogen	hydrogen	NOUN
bibechana-68838	179	14	bonds	bond	NOUN
bibechana-68838	179	15	in	in	ADP
bibechana-68838	179	16	the	the	DET
bibechana-68838	179	17	kaiso	kaiso	NOUN
bibechana-68838	179	18	-	-	PUNCT
bibechana-68838	179	19	ctcf	ctcf	NOUN
bibechana-68838	179	20	complex	complex	NOUN
bibechana-68838	179	21	.	.	PUNCT
bibechana-68838	180	1	since	since	SCONJ
bibechana-68838	180	2	most	most	ADJ
bibechana-68838	180	3	of	of	ADP
bibechana-68838	180	4	the	the	DET
bibechana-68838	180	5	residues	residue	NOUN
bibechana-68838	180	6	in	in	ADP
bibechana-68838	180	7	the	the	DET
bibechana-68838	180	8	binding	bind	VERB
bibechana-68838	180	9	interface	interface	NOUN
bibechana-68838	180	10	are	be	AUX
bibechana-68838	180	11	hydrophobic	hydrophobic	NOUN
bibechana-68838	180	12	,	,	PUNCT
bibechana-68838	180	13	the	the	DET
bibechana-68838	180	14	backbone	backbone	NOUN
bibechana-68838	180	15	atoms	atom	NOUN
bibechana-68838	180	16	are	be	AUX
bibechana-68838	180	17	involved	involve	VERB
bibechana-68838	180	18	in	in	ADP
bibechana-68838	180	19	hydrogen	hydrogen	NOUN
bibechana-68838	180	20	bonding	bonding	NOUN
bibechana-68838	180	21	.	.	PUNCT
bibechana-68838	181	1	even	even	ADV
bibechana-68838	181	2	with	with	ADP
bibechana-68838	181	3	the	the	DET
bibechana-68838	181	4	polar	polar	ADJ
bibechana-68838	181	5	residues	residue	NOUN
bibechana-68838	181	6	,	,	PUNCT
bibechana-68838	181	7	hydrogen	hydrogen	NOUN
bibechana-68838	181	8	bonds	bond	NOUN
bibechana-68838	181	9	are	be	AUX
bibechana-68838	181	10	formed	form	VERB
bibechana-68838	181	11	between	between	ADP
bibechana-68838	181	12	backbone	backbone	NOUN
bibechana-68838	181	13	atoms	atom	NOUN
bibechana-68838	181	14	as	as	SCONJ
bibechana-68838	181	15	the	the	DET
bibechana-68838	181	16	side	side	NOUN
bibechana-68838	181	17	chains	chain	NOUN
bibechana-68838	181	18	are	be	AUX
bibechana-68838	181	19	orientated	orientate	VERB
bibechana-68838	181	20	away	away	ADV
bibechana-68838	181	21	from	from	ADP
bibechana-68838	181	22	the	the	DET
bibechana-68838	181	23	binding	bind	VERB
bibechana-68838	181	24	interface	interface	NOUN
bibechana-68838	181	25	(	(	PUNCT
bibechana-68838	181	26	figure	figure	NOUN
bibechana-68838	181	27	4c	4c	NOUN
bibechana-68838	181	28	)	)	PUNCT
bibechana-68838	181	29	.	.	PUNCT
bibechana-68838	182	1	the	the	DET
bibechana-68838	182	2	backbone	backbone	NOUN
bibechana-68838	182	3	nitrogen	nitrogen	NOUN
bibechana-68838	182	4	of	of	ADP
bibechana-68838	182	5	lys689	lys689	PROPN
bibechana-68838	182	6	in	in	ADP
bibechana-68838	182	7	ctcf	ctcf	PROPN
bibechana-68838	182	8	forms	form	NOUN
bibechana-68838	182	9	a	a	DET
bibechana-68838	182	10	hydrogen	hydrogen	NOUN
bibechana-68838	182	11	bond	bond	NOUN
bibechana-68838	182	12	with	with	ADP
bibechana-68838	182	13	the	the	DET
bibechana-68838	182	14	oxygen	oxygen	NOUN
bibechana-68838	182	15	atom	atom	NOUN
bibechana-68838	182	16	of	of	ADP
bibechana-68838	182	17	glu115	glu115	PROPN
bibechana-68838	182	18	in	in	ADP
bibechana-68838	182	19	kaiso	kaiso	PROPN
bibechana-68838	182	20	.	.	PUNCT
bibechana-68838	183	1	this	this	DET
bibechana-68838	183	2	bond	bond	NOUN
bibechana-68838	183	3	is	be	AUX
bibechana-68838	183	4	formed	form	VERB
bibechana-68838	183	5	around	around	ADP
bibechana-68838	183	6	125	125	NUM
bibechana-68838	183	7	ns	ns	NUM
bibechana-68838	183	8	and	and	CCONJ
bibechana-68838	183	9	remains	remain	VERB
bibechana-68838	183	10	consistently	consistently	ADV
bibechana-68838	183	11	stable	stable	ADJ
bibechana-68838	183	12	after	after	ADP
bibechana-68838	183	13	150	150	NUM
bibechana-68838	183	14	ns	ns	NUM
bibechana-68838	183	15	,	,	PUNCT
bibechana-68838	183	16	as	as	SCONJ
bibechana-68838	183	17	shown	show	VERB
bibechana-68838	183	18	in	in	ADP
bibechana-68838	183	19	figure	figure	NOUN
bibechana-68838	183	20	4d	4d	NUM
bibechana-68838	183	21	.	.	PUNCT
bibechana-68838	184	1	similarly	similarly	ADV
bibechana-68838	184	2	,	,	PUNCT
bibechana-68838	184	3	the	the	DET
bibechana-68838	184	4	hydrogen	hydrogen	NOUN
bibechana-68838	184	5	bond	bond	NOUN
bibechana-68838	184	6	between	between	ADP
bibechana-68838	184	7	gly117	gly117	NOUN
bibechana-68838	184	8	in	in	ADP
bibechana-68838	184	9	kaiso	kaiso	NOUN
bibechana-68838	184	10	and	and	CCONJ
bibechana-68838	184	11	lys689	lys689	PROPN
bibechana-68838	184	12	in	in	ADP
bibechana-68838	184	13	ctcf	ctcf	PROPN
bibechana-68838	184	14	becomes	become	VERB
bibechana-68838	184	15	stable	stable	ADJ
bibechana-68838	184	16	after	after	ADP
bibechana-68838	184	17	150	150	NUM
bibechana-68838	184	18	ns	ns	NUM
bibechana-68838	184	19	.	.	PUNCT
bibechana-68838	185	1	in	in	ADP
bibechana-68838	185	2	addition	addition	NOUN
bibechana-68838	185	3	,	,	PUNCT
bibechana-68838	185	4	the	the	DET
bibechana-68838	185	5	backbone	backbone	NOUN
bibechana-68838	185	6	nitrogen	nitrogen	NOUN
bibechana-68838	185	7	and	and	CCONJ
bibechana-68838	185	8	oxygen	oxygen	NOUN
bibechana-68838	185	9	of	of	ADP
bibechana-68838	185	10	val93	val93	PROPN
bibechana-68838	185	11	in	in	ADP
bibechana-68838	185	12	kaiso	kaiso	NOUN
bibechana-68838	185	13	form	form	NOUN
bibechana-68838	185	14	hydrogen	hydrogen	NOUN
bibechana-68838	185	15	bonds	bond	NOUN
bibechana-68838	185	16	with	with	ADP
bibechana-68838	185	17	the	the	DET
bibechana-68838	185	18	backbone	backbone	NOUN
bibechana-68838	185	19	atoms	atom	NOUN
bibechana-68838	185	20	of	of	ADP
bibechana-68838	185	21	gln672	gln672	NOUN
bibechana-68838	185	22	and	and	CCONJ
bibechana-68838	185	23	glu674	glu674	NOUN
bibechana-68838	185	24	in	in	ADP
bibechana-68838	185	25	ctcf	ctcf	ADJ
bibechana-68838	185	26	,	,	PUNCT
bibechana-68838	185	27	respectively	respectively	ADV
bibechana-68838	185	28	.	.	PUNCT
bibechana-68838	186	1	these	these	DET
bibechana-68838	186	2	bonds	bond	NOUN
bibechana-68838	186	3	are	be	AUX
bibechana-68838	186	4	formed	form	VERB
bibechana-68838	186	5	at	at	ADP
bibechana-68838	186	6	the	the	DET
bibechana-68838	186	7	start	start	NOUN
bibechana-68838	186	8	of	of	ADP
bibechana-68838	186	9	the	the	DET
bibechana-68838	186	10	simulation	simulation	NOUN
bibechana-68838	186	11	and	and	CCONJ
bibechana-68838	186	12	remain	remain	VERB
bibechana-68838	186	13	stable	stable	ADJ
bibechana-68838	186	14	throughout	throughout	ADP
bibechana-68838	186	15	(	(	PUNCT
bibechana-68838	186	16	figure	figure	NOUN
bibechana-68838	186	17	4d	4d	NUM
bibechana-68838	186	18	)	)	PUNCT
bibechana-68838	186	19	.	.	PUNCT
bibechana-68838	187	1	in	in	ADP
bibechana-68838	187	2	addition	addition	NOUN
bibechana-68838	187	3	,	,	PUNCT
bibechana-68838	187	4	the	the	DET
bibechana-68838	187	5	bidhya	bidhya	NOUN
bibechana-68838	187	6	thapa	thapa	PROPN
bibechana-68838	187	7	and	and	CCONJ
bibechana-68838	187	8	narayan	narayan	PROPN
bibechana-68838	187	9	prasad	prasad	PROPN
bibechana-68838	187	10	adhikari/	adhikari/	NUM
bibechana-68838	187	11	bibechana	bibechana	NOUN
bibechana-68838	187	12	21	21	NUM
bibechana-68838	187	13	(	(	PUNCT
bibechana-68838	187	14	2024	2024	NUM
bibechana-68838	187	15	)	)	PUNCT
bibechana-68838	187	16	290	290	NUM
bibechana-68838	187	17	-	-	SYM
bibechana-68838	187	18	299	299	NUM
bibechana-68838	187	19	296	296	NUM
bibechana-68838	187	20	arg92(kaiso)glu674(ctcf	arg92(kaiso)glu674(ctcf	NOUN
bibechana-68838	187	21	)	)	PUNCT
bibechana-68838	187	22	is	be	AUX
bibechana-68838	187	23	the	the	DET
bibechana-68838	187	24	only	only	ADJ
bibechana-68838	187	25	major	major	ADJ
bibechana-68838	187	26	hydrogen	hydrogen	NOUN
bibechana-68838	187	27	bond	bond	NOUN
bibechana-68838	187	28	formed	form	VERB
bibechana-68838	187	29	between	between	ADP
bibechana-68838	187	30	the	the	DET
bibechana-68838	187	31	side	side	NOUN
bibechana-68838	187	32	chains	chain	NOUN
bibechana-68838	187	33	of	of	ADP
bibechana-68838	187	34	kaiso	kaiso	NOUN
bibechana-68838	187	35	and	and	CCONJ
bibechana-68838	187	36	ctcf	ctcf	NOUN
bibechana-68838	187	37	.	.	PUNCT
bibechana-68838	188	1	figure	figure	VERB
bibechana-68838	188	2	4	4	NUM
bibechana-68838	188	3	:	:	PUNCT
bibechana-68838	188	4	(	(	PUNCT
bibechana-68838	188	5	a	a	X
bibechana-68838	188	6	)	)	PUNCT
bibechana-68838	188	7	time	time	NOUN
bibechana-68838	188	8	evolution	evolution	NOUN
bibechana-68838	188	9	of	of	ADP
bibechana-68838	188	10	the	the	DET
bibechana-68838	188	11	total	total	ADJ
bibechana-68838	188	12	inter	inter	ADJ
bibechana-68838	188	13	-	-	ADJ
bibechana-68838	188	14	protein	protein	ADJ
bibechana-68838	188	15	hydrogen	hydrogen	NOUN
bibechana-68838	188	16	bonds	bond	NOUN
bibechana-68838	188	17	in	in	ADP
bibechana-68838	188	18	the	the	DET
bibechana-68838	188	19	kaiso	kaiso	NOUN
bibechana-68838	188	20	-	-	PUNCT
bibechana-68838	188	21	ctcf	ctcf	NOUN
bibechana-68838	188	22	complex	complex	NOUN
bibechana-68838	188	23	during	during	ADP
bibechana-68838	188	24	the	the	DET
bibechana-68838	188	25	simulation	simulation	NOUN
bibechana-68838	188	26	.	.	PUNCT
bibechana-68838	189	1	(	(	PUNCT
bibechana-68838	189	2	b	b	X
bibechana-68838	189	3	)	)	PUNCT
bibechana-68838	189	4	percentage	percentage	NOUN
bibechana-68838	189	5	occupancy	occupancy	NOUN
bibechana-68838	189	6	of	of	ADP
bibechana-68838	189	7	the	the	DET
bibechana-68838	189	8	major	major	ADJ
bibechana-68838	189	9	hydrogen	hydrogen	NOUN
bibechana-68838	189	10	bonds	bond	NOUN
bibechana-68838	189	11	in	in	ADP
bibechana-68838	189	12	the	the	DET
bibechana-68838	189	13	kaiso	kaiso	NOUN
bibechana-68838	189	14	-	-	PUNCT
bibechana-68838	189	15	ctcf	ctcf	NOUN
bibechana-68838	189	16	complex	complex	NOUN
bibechana-68838	189	17	.	.	PUNCT
bibechana-68838	190	1	(	(	PUNCT
bibechana-68838	190	2	c	c	X
bibechana-68838	190	3	)	)	PUNCT
bibechana-68838	190	4	details	detail	NOUN
bibechana-68838	190	5	of	of	ADP
bibechana-68838	190	6	the	the	DET
bibechana-68838	190	7	major	major	ADJ
bibechana-68838	190	8	inter	inter	ADJ
bibechana-68838	190	9	-	-	ADJ
bibechana-68838	190	10	protein	protein	ADJ
bibechana-68838	190	11	hydrogen	hydrogen	NOUN
bibechana-68838	190	12	bonds	bond	NOUN
bibechana-68838	190	13	in	in	ADP
bibechana-68838	190	14	the	the	DET
bibechana-68838	190	15	kaiso	kaiso	NOUN
bibechana-68838	190	16	-	-	PUNCT
bibechana-68838	190	17	ctcf	ctcf	NOUN
bibechana-68838	190	18	complex	complex	NOUN
bibechana-68838	190	19	(	(	PUNCT
bibechana-68838	190	20	shown	show	VERB
bibechana-68838	190	21	in	in	ADP
bibechana-68838	190	22	the	the	DET
bibechana-68838	190	23	licorice	licorice	NOUN
bibechana-68838	190	24	structure	structure	NOUN
bibechana-68838	190	25	)	)	PUNCT
bibechana-68838	190	26	.	.	PUNCT
bibechana-68838	191	1	the	the	DET
bibechana-68838	191	2	dotted	dotted	ADJ
bibechana-68838	191	3	lines	line	NOUN
bibechana-68838	191	4	represent	represent	VERB
bibechana-68838	191	5	the	the	DET
bibechana-68838	191	6	hydrogen	hydrogen	NOUN
bibechana-68838	191	7	bonds	bond	NOUN
bibechana-68838	191	8	.	.	PUNCT
bibechana-68838	192	1	(	(	PUNCT
bibechana-68838	192	2	d	d	X
bibechana-68838	192	3	)	)	PUNCT
bibechana-68838	192	4	time	time	NOUN
bibechana-68838	192	5	evolution	evolution	NOUN
bibechana-68838	192	6	of	of	ADP
bibechana-68838	192	7	the	the	DET
bibechana-68838	192	8	distance	distance	NOUN
bibechana-68838	192	9	between	between	ADP
bibechana-68838	192	10	the	the	DET
bibechana-68838	192	11	heavy	heavy	ADJ
bibechana-68838	192	12	atoms	atom	NOUN
bibechana-68838	192	13	forming	form	VERB
bibechana-68838	192	14	major	major	ADJ
bibechana-68838	192	15	inter	inter	ADJ
bibechana-68838	192	16	-	-	ADJ
bibechana-68838	192	17	protein	protein	ADJ
bibechana-68838	192	18	hydrogen	hydrogen	NOUN
bibechana-68838	192	19	bonds	bond	NOUN
bibechana-68838	192	20	in	in	ADP
bibechana-68838	192	21	the	the	DET
bibechana-68838	192	22	kaiso	kaiso	NOUN
bibechana-68838	192	23	-	-	PUNCT
bibechana-68838	192	24	ctcf	ctcf	NOUN
bibechana-68838	192	25	complex	complex	NOUN
bibechana-68838	192	26	.	.	PUNCT
bibechana-68838	193	1	ionic	ionic	ADJ
bibechana-68838	193	2	interactions	interaction	NOUN
bibechana-68838	193	3	the	the	DET
bibechana-68838	193	4	ionic	ionic	ADJ
bibechana-68838	193	5	interactions	interaction	NOUN
bibechana-68838	193	6	result	result	VERB
bibechana-68838	193	7	from	from	ADP
bibechana-68838	193	8	the	the	DET
bibechana-68838	193	9	electrostatic	electrostatic	ADJ
bibechana-68838	193	10	attraction	attraction	NOUN
bibechana-68838	193	11	between	between	ADP
bibechana-68838	193	12	the	the	DET
bibechana-68838	193	13	side	side	NOUN
bibechana-68838	193	14	chains	chain	NOUN
bibechana-68838	193	15	of	of	ADP
bibechana-68838	193	16	the	the	DET
bibechana-68838	193	17	charged	charge	VERB
bibechana-68838	193	18	residues	residue	NOUN
bibechana-68838	193	19	at	at	ADP
bibechana-68838	193	20	the	the	DET
bibechana-68838	193	21	binding	bind	VERB
bibechana-68838	193	22	interface	interface	NOUN
bibechana-68838	193	23	between	between	ADP
bibechana-68838	193	24	two	two	NUM
bibechana-68838	193	25	proteins	protein	NOUN
bibechana-68838	193	26	.	.	PUNCT
bibechana-68838	194	1	the	the	DET
bibechana-68838	194	2	negatively	negatively	ADV
bibechana-68838	194	3	charged	charge	VERB
bibechana-68838	194	4	side	side	NOUN
bibechana-68838	194	5	chain	chain	NOUN
bibechana-68838	194	6	of	of	ADP
bibechana-68838	194	7	glu674	glu674	NOUN
bibechana-68838	194	8	in	in	ADP
bibechana-68838	194	9	ctcf	ctcf	PROPN
bibechana-68838	194	10	makes	make	VERB
bibechana-68838	194	11	ionic	ionic	ADJ
bibechana-68838	194	12	interaction	interaction	NOUN
bibechana-68838	194	13	with	with	ADP
bibechana-68838	194	14	the	the	DET
bibechana-68838	194	15	positively	positively	ADV
bibechana-68838	194	16	charged	charge	VERB
bibechana-68838	194	17	side	side	NOUN
bibechana-68838	194	18	chains	chain	NOUN
bibechana-68838	194	19	of	of	ADP
bibechana-68838	194	20	arg92	arg92	NOUN
bibechana-68838	194	21	and	and	CCONJ
bibechana-68838	194	22	arg94	arg94	PROPN
bibechana-68838	194	23	of	of	ADP
bibechana-68838	194	24	kaiso	kaiso	NOUN
bibechana-68838	194	25	.	.	PUNCT
bibechana-68838	195	1	similarly	similarly	ADV
bibechana-68838	195	2	,	,	PUNCT
bibechana-68838	195	3	the	the	DET
bibechana-68838	195	4	glu115	glu115	PROPN
bibechana-68838	195	5	in	in	ADP
bibechana-68838	195	6	kaiso	kaiso	PROPN
bibechana-68838	195	7	makes	make	VERB
bibechana-68838	195	8	ionic	ionic	ADJ
bibechana-68838	195	9	interactions	interaction	NOUN
bibechana-68838	195	10	with	with	ADP
bibechana-68838	195	11	the	the	DET
bibechana-68838	195	12	side	side	NOUN
bibechana-68838	195	13	chains	chain	NOUN
bibechana-68838	195	14	of	of	ADP
bibechana-68838	195	15	lys663	lys663	PROPN
bibechana-68838	195	16	,	,	PUNCT
bibechana-68838	195	17	lys689	lys689	ADJ
bibechana-68838	195	18	,	,	PUNCT
bibechana-68838	195	19	and	and	CCONJ
bibechana-68838	195	20	lys690	lys690	VERB
bibechana-68838	195	21	in	in	ADP
bibechana-68838	195	22	ctcf	ctcf	NOUN
bibechana-68838	195	23	.	.	PUNCT
bibechana-68838	196	1	in	in	ADP
bibechana-68838	196	2	the	the	DET
bibechana-68838	196	3	kaiso	kaiso	NOUN
bibechana-68838	196	4	-	-	PUNCT
bibechana-68838	196	5	ctcf	ctcf	NOUN
bibechana-68838	196	6	complex	complex	NOUN
bibechana-68838	196	7	,	,	PUNCT
bibechana-68838	196	8	a	a	DET
bibechana-68838	196	9	strong	strong	ADJ
bibechana-68838	196	10	,	,	PUNCT
bibechana-68838	196	11	consistent	consistent	ADJ
bibechana-68838	196	12	salt	salt	NOUN
bibechana-68838	196	13	bridge	bridge	NOUN
bibechana-68838	196	14	is	be	AUX
bibechana-68838	196	15	not	not	PART
bibechana-68838	196	16	formed	form	VERB
bibechana-68838	196	17	between	between	ADP
bibechana-68838	196	18	these	these	DET
bibechana-68838	196	19	charged	charge	VERB
bibechana-68838	196	20	residues	residue	NOUN
bibechana-68838	196	21	,	,	PUNCT
bibechana-68838	196	22	as	as	SCONJ
bibechana-68838	196	23	their	their	PRON
bibechana-68838	196	24	heavy	heavy	ADJ
bibechana-68838	196	25	atom	atom	NOUN
bibechana-68838	196	26	pairs	pair	NOUN
bibechana-68838	196	27	are	be	AUX
bibechana-68838	196	28	beyond	beyond	ADP
bibechana-68838	196	29	3.2	3.2	NUM
bibechana-68838	196	30	å	å	NOUN
bibechana-68838	196	31	during	during	ADP
bibechana-68838	196	32	most	most	ADJ
bibechana-68838	196	33	of	of	ADP
bibechana-68838	196	34	the	the	DET
bibechana-68838	196	35	simulation	simulation	NOUN
bibechana-68838	196	36	time	time	NOUN
bibechana-68838	196	37	.	.	PUNCT
bibechana-68838	197	1	nevertheless	nevertheless	ADV
bibechana-68838	197	2	,	,	PUNCT
bibechana-68838	197	3	the	the	DET
bibechana-68838	197	4	arg92	arg92	NOUN
bibechana-68838	197	5	and	and	CCONJ
bibechana-68838	197	6	arg94	arg94	PROPN
bibechana-68838	197	7	in	in	ADP
bibechana-68838	197	8	kaiso	kaiso	NOUN
bibechana-68838	197	9	make	make	VERB
bibechana-68838	197	10	transient	transient	ADJ
bibechana-68838	197	11	salt	salt	NOUN
bibechana-68838	197	12	bridges	bridge	NOUN
bibechana-68838	197	13	with	with	ADP
bibechana-68838	197	14	glu674	glu674	NOUN
bibechana-68838	197	15	in	in	ADP
bibechana-68838	197	16	ctcf	ctcf	NOUN
bibechana-68838	197	17	.	.	PUNCT
bibechana-68838	198	1	these	these	DET
bibechana-68838	198	2	ionic	ionic	ADJ
bibechana-68838	198	3	interactions	interaction	NOUN
bibechana-68838	198	4	enhance	enhance	VERB
bibechana-68838	198	5	the	the	DET
bibechana-68838	198	6	binding	binding	NOUN
bibechana-68838	198	7	of	of	ADP
bibechana-68838	198	8	these	these	DET
bibechana-68838	198	9	two	two	NUM
bibechana-68838	198	10	proteins	protein	NOUN
bibechana-68838	198	11	to	to	PART
bibechana-68838	198	12	form	form	VERB
bibechana-68838	198	13	a	a	DET
bibechana-68838	198	14	stable	stable	ADJ
bibechana-68838	198	15	complex	complex	NOUN
bibechana-68838	198	16	.	.	PUNCT
bibechana-68838	199	1	we	we	PRON
bibechana-68838	199	2	further	far	ADV
bibechana-68838	199	3	estimated	estimate	VERB
bibechana-68838	199	4	the	the	DET
bibechana-68838	199	5	contribution	contribution	NOUN
bibechana-68838	199	6	of	of	ADP
bibechana-68838	199	7	the	the	DET
bibechana-68838	199	8	non	non	ADJ
bibechana-68838	199	9	-	-	ADJ
bibechana-68838	199	10	bonded	bonded	ADJ
bibechana-68838	199	11	interaction	interaction	NOUN
bibechana-68838	199	12	in	in	ADP
bibechana-68838	199	13	stabilizing	stabilize	VERB
bibechana-68838	199	14	the	the	DET
bibechana-68838	199	15	kaiso	kaiso	NOUN
bibechana-68838	199	16	-	-	PUNCT
bibechana-68838	199	17	ctcf	ctcf	NOUN
bibechana-68838	199	18	complex	complex	NOUN
bibechana-68838	199	19	.	.	PUNCT
bibechana-68838	200	1	we	we	PRON
bibechana-68838	200	2	calculated	calculate	VERB
bibechana-68838	200	3	the	the	DET
bibechana-68838	200	4	average	average	ADJ
bibechana-68838	200	5	values	value	NOUN
bibechana-68838	200	6	of	of	ADP
bibechana-68838	200	7	non	non	ADJ
bibechana-68838	200	8	-	-	ADJ
bibechana-68838	200	9	bonded	bonded	ADJ
bibechana-68838	200	10	interaction	interaction	NOUN
bibechana-68838	200	11	energy	energy	NOUN
bibechana-68838	200	12	using	use	VERB
bibechana-68838	200	13	the	the	DET
bibechana-68838	200	14	last	last	ADJ
bibechana-68838	200	15	150	150	NUM
bibechana-68838	200	16	ns	ns	NUM
bibechana-68838	200	17	of	of	ADP
bibechana-68838	200	18	the	the	DET
bibechana-68838	200	19	simulation	simulation	NOUN
bibechana-68838	200	20	trajectory	trajectory	NOUN
bibechana-68838	200	21	.	.	PUNCT
bibechana-68838	201	1	the	the	DET
bibechana-68838	201	2	electrostatic	electrostatic	ADJ
bibechana-68838	201	3	and	and	CCONJ
bibechana-68838	201	4	van	van	PROPN
bibechana-68838	201	5	der	der	NOUN
bibechana-68838	201	6	waals	waal	NOUN
bibechana-68838	201	7	interactions	interaction	NOUN
bibechana-68838	201	8	contribute	contribute	VERB
bibechana-68838	201	9	about	about	ADP
bibechana-68838	201	10	-199	-199	PROPN
bibechana-68838	201	11	±	±	NUM
bibechana-68838	201	12	72	72	NUM
bibechana-68838	201	13	kcal	kcal	NOUN
bibechana-68838	201	14	/	/	SYM
bibechana-68838	201	15	mol	mol	PROPN
bibechana-68838	201	16	and	and	CCONJ
bibechana-68838	201	17	-56	-56	PROPN
bibechana-68838	201	18	±	±	NUM
bibechana-68838	201	19	10	10	NUM
bibechana-68838	201	20	kcal	kcal	NOUN
bibechana-68838	201	21	/	/	SYM
bibechana-68838	201	22	mol	mol	NOUN
bibechana-68838	201	23	to	to	ADP
bibechana-68838	201	24	the	the	DET
bibechana-68838	201	25	total	total	ADJ
bibechana-68838	201	26	energy	energy	NOUN
bibechana-68838	201	27	of	of	ADP
bibechana-68838	201	28	the	the	DET
bibechana-68838	201	29	complex	complex	NOUN
bibechana-68838	201	30	.	.	PUNCT
bibechana-68838	202	1	bidhya	bidhya	PROPN
bibechana-68838	202	2	thapa	thapa	PROPN
bibechana-68838	202	3	and	and	CCONJ
bibechana-68838	202	4	narayan	narayan	PROPN
bibechana-68838	202	5	prasad	prasad	PROPN
bibechana-68838	202	6	adhikari/	adhikari/	NUM
bibechana-68838	202	7	bibechana	bibechana	NOUN
bibechana-68838	202	8	21	21	NUM
bibechana-68838	202	9	(	(	PUNCT
bibechana-68838	202	10	2024	2024	NUM
bibechana-68838	202	11	)	)	PUNCT
bibechana-68838	202	12	290	290	NUM
bibechana-68838	202	13	-	-	SYM
bibechana-68838	202	14	299	299	NUM
bibechana-68838	202	15	297	297	NUM
bibechana-68838	202	16	3.4	3.4	NUM
bibechana-68838	202	17	binding	bind	VERB
bibechana-68838	202	18	free	free	ADJ
bibechana-68838	202	19	energy	energy	NOUN
bibechana-68838	202	20	of	of	ADP
bibechana-68838	202	21	the	the	DET
bibechana-68838	202	22	complex	complex	NOUN
bibechana-68838	202	23	we	we	PRON
bibechana-68838	202	24	estimated	estimate	VERB
bibechana-68838	202	25	the	the	DET
bibechana-68838	202	26	binding	bind	VERB
bibechana-68838	202	27	free	free	ADJ
bibechana-68838	202	28	energy	energy	NOUN
bibechana-68838	202	29	of	of	ADP
bibechana-68838	202	30	the	the	DET
bibechana-68838	202	31	kaisoctcf	kaisoctcf	PROPN
bibechana-68838	202	32	complex	complex	NOUN
bibechana-68838	202	33	using	use	VERB
bibechana-68838	202	34	molecular	molecular	ADJ
bibechana-68838	202	35	mechanics	mechanic	NOUN
bibechana-68838	202	36	with	with	ADP
bibechana-68838	202	37	a	a	DET
bibechana-68838	202	38	generalized	generalize	VERB
bibechana-68838	202	39	born	bear	VERB
bibechana-68838	202	40	and	and	CCONJ
bibechana-68838	202	41	surface	surface	NOUN
bibechana-68838	202	42	area	area	NOUN
bibechana-68838	202	43	solvation	solvation	NOUN
bibechana-68838	202	44	(	(	PUNCT
bibechana-68838	202	45	mm	mm	NOUN
bibechana-68838	202	46	/	/	SYM
bibechana-68838	202	47	gbsa	gbsa	ADJ
bibechana-68838	202	48	)	)	PUNCT
bibechana-68838	202	49	approach	approach	NOUN
bibechana-68838	202	50	[	[	X
bibechana-68838	202	51	41–43	41–43	NUM
bibechana-68838	202	52	]	]	PUNCT
bibechana-68838	202	53	.	.	PUNCT
bibechana-68838	203	1	previous	previous	ADJ
bibechana-68838	203	2	studies	study	NOUN
bibechana-68838	203	3	have	have	AUX
bibechana-68838	203	4	shown	show	VERB
bibechana-68838	203	5	that	that	SCONJ
bibechana-68838	203	6	the	the	DET
bibechana-68838	203	7	mm	mm	PROPN
bibechana-68838	203	8	/	/	SYM
bibechana-68838	203	9	gbsa	gbsa	PROPN
bibechana-68838	203	10	method	method	NOUN
bibechana-68838	203	11	has	have	VERB
bibechana-68838	203	12	some	some	DET
bibechana-68838	203	13	limitations	limitation	NOUN
bibechana-68838	203	14	in	in	ADP
bibechana-68838	203	15	calculating	calculate	VERB
bibechana-68838	203	16	the	the	DET
bibechana-68838	203	17	absolute	absolute	ADJ
bibechana-68838	203	18	binding	binding	ADJ
bibechana-68838	203	19	free	free	ADJ
bibechana-68838	203	20	energy	energy	NOUN
bibechana-68838	203	21	of	of	ADP
bibechana-68838	203	22	the	the	DET
bibechana-68838	203	23	complex	complex	NOUN
bibechana-68838	203	24	and	and	CCONJ
bibechana-68838	203	25	tends	tend	VERB
bibechana-68838	203	26	to	to	PART
bibechana-68838	203	27	overestimate	overestimate	VERB
bibechana-68838	203	28	the	the	DET
bibechana-68838	203	29	binding	bind	VERB
bibechana-68838	203	30	free	free	ADJ
bibechana-68838	203	31	energy	energy	NOUN
bibechana-68838	203	32	[	[	X
bibechana-68838	203	33	44	44	NUM
bibechana-68838	203	34	,	,	PUNCT
bibechana-68838	203	35	45	45	NUM
bibechana-68838	203	36	]	]	PUNCT
bibechana-68838	203	37	.	.	PUNCT
bibechana-68838	204	1	however	however	ADV
bibechana-68838	204	2	,	,	PUNCT
bibechana-68838	204	3	it	it	PRON
bibechana-68838	204	4	is	be	AUX
bibechana-68838	204	5	a	a	DET
bibechana-68838	204	6	computationally	computationally	ADV
bibechana-68838	204	7	efficient	efficient	ADJ
bibechana-68838	204	8	way	way	NOUN
bibechana-68838	204	9	to	to	PART
bibechana-68838	204	10	calculate	calculate	VERB
bibechana-68838	204	11	the	the	DET
bibechana-68838	204	12	relative	relative	ADJ
bibechana-68838	204	13	binding	bind	VERB
bibechana-68838	204	14	energy	energy	NOUN
bibechana-68838	204	15	of	of	ADP
bibechana-68838	204	16	a	a	DET
bibechana-68838	204	17	complex	complex	NOUN
bibechana-68838	204	18	.	.	PUNCT
bibechana-68838	205	1	as	as	ADP
bibechana-68838	205	2	in	in	ADP
bibechana-68838	205	3	our	our	PRON
bibechana-68838	205	4	previous	previous	ADJ
bibechana-68838	205	5	works	work	NOUN
bibechana-68838	205	6	[	[	X
bibechana-68838	205	7	36	36	NUM
bibechana-68838	205	8	,	,	PUNCT
bibechana-68838	205	9	46	46	NUM
bibechana-68838	205	10	,	,	PUNCT
bibechana-68838	205	11	47	47	NUM
bibechana-68838	205	12	]	]	PUNCT
bibechana-68838	205	13	,	,	PUNCT
bibechana-68838	205	14	we	we	PRON
bibechana-68838	205	15	used	use	VERB
bibechana-68838	205	16	namd	namd	NOUN
bibechana-68838	205	17	to	to	PART
bibechana-68838	205	18	calculate	calculate	VERB
bibechana-68838	205	19	the	the	DET
bibechana-68838	205	20	mm	mm	PROPN
bibechana-68838	205	21	/	/	SYM
bibechana-68838	205	22	gbsa	gbsa	ADJ
bibechana-68838	205	23	energy	energy	NOUN
bibechana-68838	205	24	using	use	VERB
bibechana-68838	205	25	the	the	DET
bibechana-68838	205	26	simulation	simulation	NOUN
bibechana-68838	205	27	trajectories	trajectory	NOUN
bibechana-68838	205	28	from	from	ADP
bibechana-68838	205	29	the	the	DET
bibechana-68838	205	30	last	last	ADJ
bibechana-68838	205	31	150	150	NUM
bibechana-68838	205	32	ns	ns	NUM
bibechana-68838	205	33	of	of	ADP
bibechana-68838	205	34	the	the	DET
bibechana-68838	205	35	simulation	simulation	NOUN
bibechana-68838	205	36	,	,	PUNCT
bibechana-68838	205	37	where	where	SCONJ
bibechana-68838	205	38	the	the	DET
bibechana-68838	205	39	complex	complex	NOUN
bibechana-68838	205	40	is	be	AUX
bibechana-68838	205	41	properly	properly	ADV
bibechana-68838	205	42	stabilized	stabilize	VERB
bibechana-68838	205	43	.	.	PUNCT
bibechana-68838	206	1	the	the	DET
bibechana-68838	206	2	binding	bind	VERB
bibechana-68838	206	3	free	free	ADJ
bibechana-68838	206	4	energy	energy	NOUN
bibechana-68838	206	5	of	of	ADP
bibechana-68838	206	6	the	the	DET
bibechana-68838	206	7	kaiso	kaiso	NOUN
bibechana-68838	206	8	-	-	PUNCT
bibechana-68838	206	9	ctcf	ctcf	NOUN
bibechana-68838	206	10	complex	complex	NOUN
bibechana-68838	206	11	is	be	AUX
bibechana-68838	206	12	-45.1	-45.1	NUM
bibechana-68838	206	13	±	±	NUM
bibechana-68838	206	14	5.2	5.2	NUM
bibechana-68838	206	15	kcal	kcal	NOUN
bibechana-68838	206	16	/	/	SYM
bibechana-68838	206	17	mol	mol	PROPN
bibechana-68838	206	18	.	.	PUNCT
bibechana-68838	207	1	even	even	ADV
bibechana-68838	207	2	though	though	SCONJ
bibechana-68838	207	3	the	the	DET
bibechana-68838	207	4	mm	mm	PROPN
bibechana-68838	207	5	/	/	SYM
bibechana-68838	207	6	gbsa	gbsa	ADJ
bibechana-68838	207	7	approach	approach	NOUN
bibechana-68838	207	8	overestimates	overestimate	VERB
bibechana-68838	207	9	the	the	DET
bibechana-68838	207	10	binding	bind	VERB
bibechana-68838	207	11	free	free	ADJ
bibechana-68838	207	12	energy	energy	NOUN
bibechana-68838	208	1	[	[	X
bibechana-68838	208	2	45	45	NUM
bibechana-68838	208	3	]	]	PUNCT
bibechana-68838	208	4	,	,	PUNCT
bibechana-68838	208	5	comparing	compare	VERB
bibechana-68838	208	6	this	this	DET
bibechana-68838	208	7	value	value	NOUN
bibechana-68838	208	8	with	with	ADP
bibechana-68838	208	9	our	our	PRON
bibechana-68838	208	10	previous	previous	ADJ
bibechana-68838	208	11	works	work	NOUN
bibechana-68838	208	12	[	[	X
bibechana-68838	208	13	46	46	NUM
bibechana-68838	208	14	,	,	PUNCT
bibechana-68838	208	15	47	47	NUM
bibechana-68838	208	16	]	]	PUNCT
bibechana-68838	208	17	using	use	VERB
bibechana-68838	208	18	the	the	DET
bibechana-68838	208	19	same	same	ADJ
bibechana-68838	208	20	method	method	NOUN
bibechana-68838	208	21	indicates	indicate	VERB
bibechana-68838	208	22	a	a	DET
bibechana-68838	208	23	stable	stable	ADJ
bibechana-68838	208	24	complex	complex	NOUN
bibechana-68838	208	25	between	between	ADP
bibechana-68838	208	26	kaiso	kaiso	NOUN
bibechana-68838	208	27	and	and	CCONJ
bibechana-68838	208	28	ctcf	ctcf	NOUN
bibechana-68838	208	29	.	.	PUNCT
bibechana-68838	209	1	4	4	NUM
bibechana-68838	209	2	conclusion	conclusion	NOUN
bibechana-68838	209	3	in	in	ADP
bibechana-68838	209	4	this	this	DET
bibechana-68838	209	5	work	work	NOUN
bibechana-68838	209	6	,	,	PUNCT
bibechana-68838	209	7	we	we	PRON
bibechana-68838	209	8	employed	employ	VERB
bibechana-68838	209	9	the	the	DET
bibechana-68838	209	10	neural	neural	ADJ
bibechana-68838	209	11	networkbased	networkbase	VERB
bibechana-68838	209	12	modeling	modeling	NOUN
bibechana-68838	209	13	method	method	NOUN
bibechana-68838	209	14	alphafold2	alphafold2	PROPN
bibechana-68838	209	15	and	and	CCONJ
bibechana-68838	209	16	md	md	PROPN
bibechana-68838	209	17	simulation	simulation	NOUN
bibechana-68838	209	18	to	to	PART
bibechana-68838	209	19	predict	predict	VERB
bibechana-68838	209	20	the	the	DET
bibechana-68838	209	21	complex	complex	NOUN
bibechana-68838	209	22	between	between	ADP
bibechana-68838	209	23	the	the	DET
bibechana-68838	209	24	kaiso	kaiso	NOUN
bibechana-68838	209	25	and	and	CCONJ
bibechana-68838	209	26	ctcf	ctcf	NOUN
bibechana-68838	209	27	and	and	CCONJ
bibechana-68838	209	28	investigated	investigate	VERB
bibechana-68838	209	29	the	the	DET
bibechana-68838	209	30	structural	structural	ADJ
bibechana-68838	209	31	features	feature	NOUN
bibechana-68838	209	32	of	of	ADP
bibechana-68838	209	33	the	the	DET
bibechana-68838	209	34	predicted	predict	VERB
bibechana-68838	209	35	kaiso	kaiso	NOUN
bibechana-68838	209	36	-	-	PUNCT
bibechana-68838	209	37	ctcf	ctcf	NOUN
bibechana-68838	209	38	complex	complex	NOUN
bibechana-68838	209	39	.	.	PUNCT
bibechana-68838	210	1	we	we	PRON
bibechana-68838	210	2	predicted	predict	VERB
bibechana-68838	210	3	the	the	DET
bibechana-68838	210	4	specific	specific	ADJ
bibechana-68838	210	5	binding	bind	VERB
bibechana-68838	210	6	region	region	NOUN
bibechana-68838	210	7	as	as	ADV
bibechana-68838	210	8	well	well	ADV
bibechana-68838	210	9	as	as	ADP
bibechana-68838	210	10	the	the	DET
bibechana-68838	210	11	key	key	ADJ
bibechana-68838	210	12	residues	residue	NOUN
bibechana-68838	210	13	and	and	CCONJ
bibechana-68838	210	14	their	their	PRON
bibechana-68838	210	15	role	role	NOUN
bibechana-68838	210	16	in	in	ADP
bibechana-68838	210	17	forming	form	VERB
bibechana-68838	210	18	and	and	CCONJ
bibechana-68838	210	19	stabilizing	stabilize	VERB
bibechana-68838	210	20	the	the	DET
bibechana-68838	210	21	complex	complex	NOUN
bibechana-68838	210	22	.	.	PUNCT
bibechana-68838	211	1	in	in	ADP
bibechana-68838	211	2	addition	addition	NOUN
bibechana-68838	211	3	,	,	PUNCT
bibechana-68838	211	4	we	we	PRON
bibechana-68838	211	5	studied	study	VERB
bibechana-68838	211	6	the	the	DET
bibechana-68838	211	7	atomiclevel	atomiclevel	ADJ
bibechana-68838	211	8	detailed	detailed	ADJ
bibechana-68838	211	9	dynamics	dynamic	NOUN
bibechana-68838	211	10	of	of	ADP
bibechana-68838	211	11	various	various	ADJ
bibechana-68838	211	12	inter	inter	ADJ
bibechana-68838	211	13	-	-	ADJ
bibechana-68838	211	14	protein	protein	ADJ
bibechana-68838	211	15	noncovalent	noncovalent	NOUN
bibechana-68838	211	16	interactions	interaction	NOUN
bibechana-68838	211	17	to	to	PART
bibechana-68838	211	18	understand	understand	VERB
bibechana-68838	211	19	the	the	DET
bibechana-68838	211	20	complex	complex	ADJ
bibechana-68838	211	21	formation	formation	NOUN
bibechana-68838	211	22	between	between	ADP
bibechana-68838	211	23	the	the	DET
bibechana-68838	211	24	ctcf	ctcf	NOUN
bibechana-68838	211	25	and	and	CCONJ
bibechana-68838	211	26	kaiso	kaiso	NOUN
bibechana-68838	211	27	.	.	PUNCT
bibechana-68838	212	1	our	our	PRON
bibechana-68838	212	2	results	result	NOUN
bibechana-68838	212	3	show	show	VERB
bibechana-68838	212	4	that	that	SCONJ
bibechana-68838	212	5	the	the	DET
bibechana-68838	212	6	residues	residue	NOUN
bibechana-68838	212	7	662	662	NUM
bibechana-68838	212	8	-	-	SYM
bibechana-68838	212	9	690	690	NUM
bibechana-68838	212	10	towards	towards	ADP
bibechana-68838	212	11	the	the	DET
bibechana-68838	212	12	end	end	NOUN
bibechana-68838	212	13	of	of	ADP
bibechana-68838	212	14	the	the	DET
bibechana-68838	212	15	c	c	NOUN
bibechana-68838	212	16	-	-	PUNCT
bibechana-68838	212	17	terminal	terminal	ADJ
bibechana-68838	212	18	end	end	NOUN
bibechana-68838	212	19	of	of	ADP
bibechana-68838	212	20	ctcf	ctcf	NOUN
bibechana-68838	212	21	,	,	PUNCT
bibechana-68838	212	22	containing	contain	VERB
bibechana-68838	212	23	a	a	DET
bibechana-68838	212	24	-sheet	-sheet	NOUN
bibechana-68838	212	25	with	with	ADP
bibechana-68838	212	26	two	two	NUM
bibechana-68838	212	27	parallel	parallel	ADJ
bibechana-68838	212	28	-strands	-strand	NOUN
bibechana-68838	212	29	,	,	PUNCT
bibechana-68838	212	30	bind	bind	VERB
bibechana-68838	212	31	with	with	ADP
bibechana-68838	212	32	the	the	DET
bibechana-68838	212	33	btb	btb	NOUN
bibechana-68838	212	34	/	/	SYM
bibechana-68838	212	35	poz	poz	PROPN
bibechana-68838	212	36	domain	domain	NOUN
bibechana-68838	212	37	of	of	ADP
bibechana-68838	212	38	kaiso	kaiso	NOUN
bibechana-68838	212	39	.	.	PUNCT
bibechana-68838	213	1	our	our	PRON
bibechana-68838	213	2	simulation	simulation	NOUN
bibechana-68838	213	3	results	result	NOUN
bibechana-68838	213	4	reveal	reveal	VERB
bibechana-68838	213	5	that	that	SCONJ
bibechana-68838	213	6	hydrophobic	hydrophobic	NOUN
bibechana-68838	213	7	interactions	interaction	NOUN
bibechana-68838	213	8	between	between	ADP
bibechana-68838	213	9	the	the	DET
bibechana-68838	213	10	inter	inter	ADJ
bibechana-68838	213	11	-	-	ADJ
bibechana-68838	213	12	facial	facial	ADJ
bibechana-68838	213	13	residues	residue	NOUN
bibechana-68838	213	14	are	be	AUX
bibechana-68838	213	15	crucial	crucial	ADJ
bibechana-68838	213	16	in	in	ADP
bibechana-68838	213	17	forming	form	VERB
bibechana-68838	213	18	the	the	DET
bibechana-68838	213	19	stable	stable	ADJ
bibechana-68838	213	20	complex	complex	NOUN
bibechana-68838	213	21	between	between	ADP
bibechana-68838	213	22	kaiso	kaiso	NOUN
bibechana-68838	213	23	and	and	CCONJ
bibechana-68838	213	24	ctcf	ctcf	NOUN
bibechana-68838	213	25	.	.	PUNCT
bibechana-68838	214	1	in	in	ADP
bibechana-68838	214	2	addition	addition	NOUN
bibechana-68838	214	3	,	,	PUNCT
bibechana-68838	214	4	several	several	ADJ
bibechana-68838	214	5	hydrogen	hydrogen	NOUN
bibechana-68838	214	6	bonding	bonding	NOUN
bibechana-68838	214	7	and	and	CCONJ
bibechana-68838	214	8	ionic	ionic	ADJ
bibechana-68838	214	9	interactions	interaction	NOUN
bibechana-68838	214	10	are	be	AUX
bibechana-68838	214	11	essential	essential	ADJ
bibechana-68838	214	12	for	for	ADP
bibechana-68838	214	13	binding	bind	VERB
bibechana-68838	214	14	two	two	NUM
bibechana-68838	214	15	proteins	protein	NOUN
bibechana-68838	214	16	.	.	PUNCT
bibechana-68838	215	1	similarly	similarly	ADV
bibechana-68838	215	2	,	,	PUNCT
bibechana-68838	215	3	electrostatic	electrostatic	ADJ
bibechana-68838	215	4	and	and	CCONJ
bibechana-68838	215	5	van	van	PROPN
bibechana-68838	215	6	der	der	NOUN
bibechana-68838	215	7	waals	waal	NOUN
bibechana-68838	215	8	interactions	interaction	NOUN
bibechana-68838	215	9	also	also	ADV
bibechana-68838	215	10	contribute	contribute	VERB
bibechana-68838	215	11	to	to	ADP
bibechana-68838	215	12	complex	complex	ADJ
bibechana-68838	215	13	stabilization	stabilization	NOUN
bibechana-68838	215	14	.	.	PUNCT
bibechana-68838	216	1	the	the	DET
bibechana-68838	216	2	significant	significant	ADJ
bibechana-68838	216	3	value	value	NOUN
bibechana-68838	216	4	of	of	ADP
bibechana-68838	216	5	hydrophobic	hydrophobic	NOUN
bibechana-68838	216	6	contact	contact	NOUN
bibechana-68838	216	7	area	area	NOUN
bibechana-68838	216	8	and	and	CCONJ
bibechana-68838	216	9	binding	bind	VERB
bibechana-68838	216	10	free	free	ADJ
bibechana-68838	216	11	energy	energy	NOUN
bibechana-68838	216	12	indicate	indicate	VERB
bibechana-68838	216	13	the	the	DET
bibechana-68838	216	14	stability	stability	NOUN
bibechana-68838	216	15	of	of	ADP
bibechana-68838	216	16	the	the	DET
bibechana-68838	216	17	predicted	predict	VERB
bibechana-68838	216	18	complex	complex	NOUN
bibechana-68838	216	19	.	.	PUNCT
bibechana-68838	217	1	to	to	ADP
bibechana-68838	217	2	the	the	DET
bibechana-68838	217	3	best	good	ADJ
bibechana-68838	217	4	of	of	ADP
bibechana-68838	217	5	our	our	PRON
bibechana-68838	217	6	knowledge	knowledge	NOUN
bibechana-68838	217	7	,	,	PUNCT
bibechana-68838	217	8	it	it	PRON
bibechana-68838	217	9	is	be	AUX
bibechana-68838	217	10	the	the	DET
bibechana-68838	217	11	first	first	ADJ
bibechana-68838	217	12	computational	computational	ADJ
bibechana-68838	217	13	work	work	NOUN
bibechana-68838	217	14	in	in	ADP
bibechana-68838	217	15	modeling	model	VERB
bibechana-68838	217	16	the	the	DET
bibechana-68838	217	17	kaiso	kaiso	NOUN
bibechana-68838	217	18	-	-	PUNCT
bibechana-68838	217	19	ctcf	ctcf	NOUN
bibechana-68838	217	20	complex	complex	NOUN
bibechana-68838	217	21	and	and	CCONJ
bibechana-68838	217	22	investigating	investigate	VERB
bibechana-68838	217	23	its	its	PRON
bibechana-68838	217	24	structural	structural	ADJ
bibechana-68838	217	25	features	feature	NOUN
bibechana-68838	217	26	.	.	PUNCT
bibechana-68838	218	1	previous	previous	ADJ
bibechana-68838	218	2	studies	study	NOUN
bibechana-68838	218	3	have	have	AUX
bibechana-68838	218	4	reported	report	VERB
bibechana-68838	218	5	that	that	SCONJ
bibechana-68838	218	6	kaiso	kaiso	NOUN
bibechana-68838	218	7	-	-	PUNCT
bibechana-68838	218	8	ctcf	ctcf	NOUN
bibechana-68838	218	9	interaction	interaction	NOUN
bibechana-68838	218	10	negatively	negatively	ADV
bibechana-68838	218	11	regulates	regulate	VERB
bibechana-68838	218	12	ctcf	ctcf	ADJ
bibechana-68838	218	13	insulator	insulator	NOUN
bibechana-68838	218	14	activity	activity	NOUN
bibechana-68838	218	15	[	[	X
bibechana-68838	218	16	25	25	NUM
bibechana-68838	218	17	]	]	PUNCT
bibechana-68838	218	18	;	;	PUNCT
bibechana-68838	218	19	our	our	PRON
bibechana-68838	218	20	first	first	ADJ
bibechana-68838	218	21	structural	structural	ADJ
bibechana-68838	218	22	characterization	characterization	NOUN
bibechana-68838	218	23	outlines	outline	VERB
bibechana-68838	218	24	the	the	DET
bibechana-68838	218	25	molecular	molecular	ADJ
bibechana-68838	218	26	basis	basis	NOUN
bibechana-68838	218	27	of	of	ADP
bibechana-68838	218	28	the	the	DET
bibechana-68838	218	29	interaction	interaction	NOUN
bibechana-68838	218	30	of	of	ADP
bibechana-68838	218	31	kaiso	kaiso	NOUN
bibechana-68838	218	32	with	with	ADP
bibechana-68838	218	33	ctcf	ctcf	PROPN
bibechana-68838	218	34	.	.	PUNCT
bibechana-68838	219	1	acknowledgments	acknowledgment	NOUN
bibechana-68838	219	2	bt	bt	PROPN
bibechana-68838	219	3	and	and	CCONJ
bibechana-68838	219	4	npa	npa	PROPN
bibechana-68838	219	5	acknowledge	acknowledge	VERB
bibechana-68838	219	6	support	support	NOUN
bibechana-68838	219	7	from	from	ADP
bibechana-68838	219	8	the	the	DET
bibechana-68838	219	9	research	research	NOUN
bibechana-68838	219	10	coordination	coordination	NOUN
bibechana-68838	219	11	and	and	CCONJ
bibechana-68838	219	12	development	development	NOUN
bibechana-68838	219	13	council	council	PROPN
bibechana-68838	219	14	(	(	PUNCT
bibechana-68838	219	15	rcdc	rcdc	NOUN
bibechana-68838	219	16	)	)	PUNCT
bibechana-68838	219	17	of	of	ADP
bibechana-68838	219	18	tribhuvan	tribhuvan	PROPN
bibechana-68838	219	19	university	university	PROPN
bibechana-68838	219	20	grants	grant	NOUN
bibechana-68838	219	21	number	number	NOUN
bibechana-68838	219	22	tu	tu	PROPN
bibechana-68838	219	23	-	-	PUNCT
bibechana-68838	219	24	npar-077/78	npar-077/78	PROPN
bibechana-68838	219	25	-	-	PUNCT
bibechana-68838	219	26	erg	erg	PROPN
bibechana-68838	219	27	14	14	NUM
bibechana-68838	219	28	.	.	PUNCT
bibechana-68838	220	1	bt	bt	PROPN
bibechana-68838	220	2	acknowledges	acknowledge	VERB
bibechana-68838	220	3	the	the	DET
bibechana-68838	220	4	phd	phd	NOUN
bibechana-68838	220	5	fellowship	fellowship	NOUN
bibechana-68838	220	6	and	and	CCONJ
bibechana-68838	220	7	research	research	NOUN
bibechana-68838	220	8	support	support	NOUN
bibechana-68838	220	9	grant	grant	NOUN
bibechana-68838	220	10	(	(	PUNCT
bibechana-68838	220	11	award	award	NOUN
bibechana-68838	220	12	number	number	NOUN
bibechana-68838	220	13	phd-78/79	phd-78/79	NOUN
bibechana-68838	220	14	-	-	PUNCT
bibechana-68838	220	15	s&t-15	s&t-15	NOUN
bibechana-68838	220	16	)	)	PUNCT
bibechana-68838	220	17	from	from	ADP
bibechana-68838	220	18	the	the	DET
bibechana-68838	220	19	university	university	NOUN
bibechana-68838	220	20	grants	grant	NOUN
bibechana-68838	220	21	commission	commission	PROPN
bibechana-68838	220	22	(	(	PUNCT
bibechana-68838	220	23	ugc	ugc	PROPN
bibechana-68838	220	24	)	)	PUNCT
bibechana-68838	220	25	,	,	PUNCT
bibechana-68838	220	26	nepal	nepal	PROPN
bibechana-68838	220	27	.	.	PUNCT
bibechana-68838	221	1	author	author	NOUN
bibechana-68838	221	2	contributions	contribution	NOUN
bibechana-68838	221	3	bt	bt	PROPN
bibechana-68838	221	4	performed	perform	VERB
bibechana-68838	221	5	the	the	DET
bibechana-68838	221	6	modeling	modeling	NOUN
bibechana-68838	221	7	and	and	CCONJ
bibechana-68838	221	8	md	md	PROPN
bibechana-68838	221	9	simulation	simulation	PROPN
bibechana-68838	221	10	,	,	PUNCT
bibechana-68838	221	11	analyzed	analyze	VERB
bibechana-68838	221	12	the	the	DET
bibechana-68838	221	13	data	datum	NOUN
bibechana-68838	221	14	,	,	PUNCT
bibechana-68838	221	15	and	and	CCONJ
bibechana-68838	221	16	wrote	write	VERB
bibechana-68838	221	17	the	the	DET
bibechana-68838	221	18	manuscript	manuscript	NOUN
bibechana-68838	221	19	.	.	PUNCT
bibechana-68838	222	1	npa	npa	PROPN
bibechana-68838	222	2	supervised	supervise	VERB
bibechana-68838	222	3	the	the	DET
bibechana-68838	222	4	work	work	NOUN
bibechana-68838	222	5	and	and	CCONJ
bibechana-68838	222	6	contributed	contribute	VERB
bibechana-68838	222	7	to	to	ADP
bibechana-68838	222	8	data	data	NOUN
bibechana-68838	222	9	analysis	analysis	NOUN
bibechana-68838	222	10	and	and	CCONJ
bibechana-68838	222	11	interpretation	interpretation	NOUN
bibechana-68838	222	12	.	.	PUNCT
bibechana-68838	223	1	data	datum	NOUN
bibechana-68838	223	2	availability	availability	NOUN
bibechana-68838	223	3	the	the	DET
bibechana-68838	223	4	data	datum	NOUN
bibechana-68838	223	5	supporting	support	VERB
bibechana-68838	223	6	the	the	DET
bibechana-68838	223	7	findings	finding	NOUN
bibechana-68838	223	8	of	of	ADP
bibechana-68838	223	9	this	this	DET
bibechana-68838	223	10	study	study	NOUN
bibechana-68838	223	11	are	be	AUX
bibechana-68838	223	12	available	available	ADJ
bibechana-68838	223	13	from	from	ADP
bibechana-68838	223	14	the	the	DET
bibechana-68838	223	15	corresponding	corresponding	ADJ
bibechana-68838	223	16	author	author	NOUN
bibechana-68838	223	17	upon	upon	SCONJ
bibechana-68838	223	18	reasonable	reasonable	ADJ
bibechana-68838	223	19	request	request	NOUN
bibechana-68838	223	20	.	.	PUNCT
bibechana-68838	224	1	references	reference	NOUN
bibechana-68838	224	2	[	[	X
bibechana-68838	224	3	1	1	NUM
bibechana-68838	224	4	]	]	PUNCT
bibechana-68838	224	5	bi	bi	ADJ
bibechana-68838	224	6	bassey	bassey	PROPN
bibechana-68838	224	7	-	-	PUNCT
bibechana-68838	224	8	archibong	archibong	PROPN
bibechana-68838	224	9	et	et	PROPN
bibechana-68838	224	10	al	al	PROPN
bibechana-68838	224	11	.	.	PROPN
bibechana-68838	225	1	kaiso	kaiso	PROPN
bibechana-68838	225	2	depletion	depletion	NOUN
bibechana-68838	225	3	attenuates	attenuate	VERB
bibechana-68838	225	4	the	the	DET
bibechana-68838	225	5	growth	growth	NOUN
bibechana-68838	225	6	and	and	CCONJ
bibechana-68838	225	7	survival	survival	NOUN
bibechana-68838	225	8	of	of	ADP
bibechana-68838	225	9	triple	triple	ADJ
bibechana-68838	225	10	negative	negative	ADJ
bibechana-68838	225	11	breast	breast	NOUN
bibechana-68838	225	12	cancer	cancer	NOUN
bibechana-68838	225	13	cells	cell	NOUN
bibechana-68838	225	14	.	.	PUNCT
bibechana-68838	226	1	cell	cell	NOUN
bibechana-68838	226	2	death	death	NOUN
bibechana-68838	226	3	&	&	CCONJ
bibechana-68838	226	4	disease	disease	PROPN
bibechana-68838	226	5	,	,	PUNCT
bibechana-68838	226	6	8(3):e2689	8(3):e2689	NUM
bibechana-68838	226	7	–	–	PUNCT
bibechana-68838	226	8	e2689	e2689	NOUN
bibechana-68838	226	9	,	,	PUNCT
bibechana-68838	226	10	2017	2017	NUM
bibechana-68838	226	11	.	.	PUNCT
bibechana-68838	227	1	[	[	X
bibechana-68838	227	2	2	2	X
bibechana-68838	227	3	]	]	PUNCT
bibechana-68838	227	4	sd	sd	X
bibechana-68838	227	5	dai	dai	PROPN
bibechana-68838	227	6	et	et	PROPN
bibechana-68838	227	7	al	al	PROPN
bibechana-68838	227	8	.	.	PROPN
bibechana-68838	227	9	cytoplasmic	cytoplasmic	ADJ
bibechana-68838	227	10	kaiso	kaiso	PROPN
bibechana-68838	227	11	is	be	AUX
bibechana-68838	227	12	associated	associate	VERB
bibechana-68838	227	13	with	with	ADP
bibechana-68838	227	14	poor	poor	ADJ
bibechana-68838	227	15	prognosis	prognosis	NOUN
bibechana-68838	227	16	in	in	ADP
bibechana-68838	227	17	non	non	ADJ
bibechana-68838	227	18	-	-	ADJ
bibechana-68838	227	19	small	small	ADJ
bibechana-68838	227	20	cell	cell	NOUN
bibechana-68838	227	21	lung	lung	NOUN
bibechana-68838	227	22	cancer	cancer	NOUN
bibechana-68838	227	23	.	.	PUNCT
bibechana-68838	228	1	bmc	bmc	NOUN
bibechana-68838	228	2	cancer	cancer	NOUN
bibechana-68838	228	3	,	,	PUNCT
bibechana-68838	228	4	9:1–13	9:1–13	NUM
bibechana-68838	228	5	,	,	PUNCT
bibechana-68838	228	6	2009	2009	NUM
bibechana-68838	228	7	.	.	PUNCT
bibechana-68838	229	1	[	[	X
bibechana-68838	229	2	3	3	X
bibechana-68838	229	3	]	]	X
bibechana-68838	229	4	jm	jm	PROPN
bibechana-68838	229	5	daniel	daniel	PROPN
bibechana-68838	229	6	and	and	CCONJ
bibechana-68838	229	7	ab	ab	PROPN
bibechana-68838	229	8	reynolds	reynolds	PROPN
bibechana-68838	229	9	.	.	PUNCT
bibechana-68838	230	1	the	the	DET
bibechana-68838	230	2	catenin	catenin	NOUN
bibechana-68838	230	3	p120ctn	p120ctn	PROPN
bibechana-68838	230	4	interacts	interact	VERB
bibechana-68838	230	5	with	with	ADP
bibechana-68838	230	6	kaiso	kaiso	NOUN
bibechana-68838	230	7	,	,	PUNCT
bibechana-68838	230	8	a	a	DET
bibechana-68838	230	9	novel	novel	ADJ
bibechana-68838	230	10	btb	btb	NOUN
bibechana-68838	230	11	/	/	SYM
bibechana-68838	230	12	poz	poz	PROPN
bibechana-68838	230	13	domain	domain	NOUN
bibechana-68838	230	14	zinc	zinc	NOUN
bibechana-68838	230	15	finger	finger	NOUN
bibechana-68838	230	16	transcription	transcription	NOUN
bibechana-68838	230	17	factor	factor	NOUN
bibechana-68838	230	18	.	.	PUNCT
bibechana-68838	231	1	molecular	molecular	ADJ
bibechana-68838	231	2	and	and	CCONJ
bibechana-68838	231	3	cellular	cellular	ADJ
bibechana-68838	231	4	biology	biology	NOUN
bibechana-68838	231	5	,	,	PUNCT
bibechana-68838	231	6	19(5):3614–3623	19(5):3614–3623	NUM
bibechana-68838	231	7	,	,	PUNCT
bibechana-68838	231	8	1999	1999	NUM
bibechana-68838	231	9	.	.	PUNCT
bibechana-68838	232	1	[	[	X
bibechana-68838	232	2	4	4	X
bibechana-68838	232	3	]	]	PUNCT
bibechana-68838	232	4	jm	jm	PROPN
bibechana-68838	232	5	daniel	daniel	PROPN
bibechana-68838	232	6	et	et	PROPN
bibechana-68838	232	7	al	al	PROPN
bibechana-68838	232	8	.	.	PUNCT
bibechana-68838	233	1	the	the	DET
bibechana-68838	233	2	p120ctn	p120ctn	PROPN
bibechana-68838	233	3	-	-	PUNCT
bibechana-68838	233	4	binding	bind	VERB
bibechana-68838	233	5	partner	partner	NOUN
bibechana-68838	233	6	kaiso	kaiso	NOUN
bibechana-68838	233	7	is	be	AUX
bibechana-68838	233	8	a	a	DET
bibechana-68838	233	9	bi	bi	ADJ
bibechana-68838	233	10	-	-	ADJ
bibechana-68838	233	11	modal	modal	ADJ
bibechana-68838	233	12	dna	dna	NOUN
bibechana-68838	233	13	-	-	PUNCT
bibechana-68838	233	14	binding	bind	VERB
bibechana-68838	233	15	protein	protein	NOUN
bibechana-68838	233	16	that	that	PRON
bibechana-68838	233	17	recognizes	recognize	VERB
bibechana-68838	233	18	both	both	PRON
bibechana-68838	233	19	a	a	DET
bibechana-68838	233	20	sequence	sequence	NOUN
bibechana-68838	233	21	-	-	PUNCT
bibechana-68838	233	22	specific	specific	ADJ
bibechana-68838	233	23	consensus	consensus	NOUN
bibechana-68838	233	24	and	and	CCONJ
bibechana-68838	233	25	methylated	methylate	VERB
bibechana-68838	233	26	cpg	cpg	NOUN
bibechana-68838	233	27	dinucleotides	dinucleotide	VERB
bibechana-68838	233	28	.	.	PUNCT
bibechana-68838	234	1	nucleic	nucleic	ADJ
bibechana-68838	234	2	acids	acid	NOUN
bibechana-68838	234	3	research	research	NOUN
bibechana-68838	234	4	,	,	PUNCT
bibechana-68838	234	5	30(13):2911–2919	30(13):2911–2919	PROPN
bibechana-68838	234	6	,	,	PUNCT
bibechana-68838	234	7	2002	2002	NUM
bibechana-68838	234	8	.	.	PUNCT
bibechana-68838	235	1	[	[	X
bibechana-68838	235	2	5	5	X
bibechana-68838	235	3	]	]	X
bibechana-68838	235	4	j	j	PROPN
bibechana-68838	235	5	jen	jen	PROPN
bibechana-68838	235	6	and	and	CCONJ
bibechana-68838	235	7	yc	yc	PROPN
bibechana-68838	235	8	wang	wang	PROPN
bibechana-68838	235	9	.	.	PUNCT
bibechana-68838	236	1	zinc	zinc	NOUN
bibechana-68838	236	2	finger	finger	NOUN
bibechana-68838	236	3	proteins	protein	NOUN
bibechana-68838	236	4	in	in	ADP
bibechana-68838	236	5	cancer	cancer	NOUN
bibechana-68838	236	6	progression	progression	NOUN
bibechana-68838	236	7	.	.	PUNCT
bibechana-68838	237	1	journal	journal	PROPN
bibechana-68838	237	2	of	of	ADP
bibechana-68838	237	3	biomedical	biomedical	ADJ
bibechana-68838	237	4	science	science	NOUN
bibechana-68838	237	5	,	,	PUNCT
bibechana-68838	237	6	23(1):53	23(1):53	PROPN
bibechana-68838	237	7	,	,	PUNCT
bibechana-68838	237	8	2016	2016	NUM
bibechana-68838	237	9	.	.	PUNCT
bibechana-68838	238	1	[	[	X
bibechana-68838	238	2	6	6	NUM
bibechana-68838	238	3	]	]	X
bibechana-68838	238	4	j	j	PROPN
bibechana-68838	238	5	jones	jones	PROPN
bibechana-68838	238	6	et	et	PROPN
bibechana-68838	238	7	al	al	PROPN
bibechana-68838	238	8	.	.	PUNCT
bibechana-68838	238	9	nuclear	nuclear	ADJ
bibechana-68838	238	10	kaiso	kaiso	PROPN
bibechana-68838	238	11	indicates	indicate	VERB
bibechana-68838	238	12	aggressive	aggressive	ADJ
bibechana-68838	238	13	prostate	prostate	NOUN
bibechana-68838	238	14	cancers	cancer	NOUN
bibechana-68838	238	15	and	and	CCONJ
bibechana-68838	238	16	promotes	promote	VERB
bibechana-68838	238	17	migration	migration	NOUN
bibechana-68838	238	18	and	and	CCONJ
bibechana-68838	238	19	invasiveness	invasiveness	NOUN
bibechana-68838	238	20	of	of	ADP
bibechana-68838	238	21	prostate	prostate	NOUN
bibechana-68838	238	22	cancer	cancer	NOUN
bibechana-68838	238	23	cells	cell	NOUN
bibechana-68838	238	24	.	.	PUNCT
bibechana-68838	239	1	the	the	DET
bibechana-68838	239	2	american	american	PROPN
bibechana-68838	239	3	journal	journal	PROPN
bibechana-68838	239	4	of	of	ADP
bibechana-68838	239	5	pathology	pathology	PROPN
bibechana-68838	239	6	,	,	PUNCT
bibechana-68838	239	7	181(5):1836	181(5):1836	NUM
bibechana-68838	239	8	–	–	PUNCT
bibechana-68838	239	9	1846	1846	NUM
bibechana-68838	239	10	,	,	PUNCT
bibechana-68838	239	11	2012	2012	NUM
bibechana-68838	239	12	.	.	PUNCT
bibechana-68838	240	1	[	[	X
bibechana-68838	240	2	7	7	NUM
bibechana-68838	240	3	]	]	PUNCT
bibechana-68838	240	4	cc	cc	NOUN
bibechana-68838	240	5	pierre	pierre	PROPN
bibechana-68838	240	6	et	et	PROPN
bibechana-68838	240	7	al	al	PROPN
bibechana-68838	240	8	.	.	PUNCT
bibechana-68838	240	9	dancing	dance	VERB
bibechana-68838	240	10	from	from	ADP
bibechana-68838	240	11	bottoms	bottom	NOUN
bibechana-68838	240	12	up	up	ADP
bibechana-68838	240	13	–	–	PUNCT
bibechana-68838	240	14	roles	role	NOUN
bibechana-68838	240	15	of	of	ADP
bibechana-68838	240	16	the	the	DET
bibechana-68838	240	17	poz	poz	PROPN
bibechana-68838	240	18	-	-	PROPN
bibechana-68838	240	19	zf	zf	PROPN
bibechana-68838	240	20	transcription	transcription	NOUN
bibechana-68838	240	21	factor	factor	NOUN
bibechana-68838	240	22	kaiso	kaiso	NOUN
bibechana-68838	240	23	in	in	ADP
bibechana-68838	240	24	cancer	cancer	NOUN
bibechana-68838	240	25	.	.	PUNCT
bibechana-68838	241	1	biochimica	biochimica	PROPN
bibechana-68838	241	2	et	et	PROPN
bibechana-68838	241	3	biophysica	biophysica	PROPN
bibechana-68838	241	4	acta	acta	PROPN
bibechana-68838	241	5	(	(	PUNCT
bibechana-68838	241	6	bba)reviews	bba)reviews	PROPN
bibechana-68838	241	7	on	on	ADP
bibechana-68838	241	8	cancer	cancer	NOUN
bibechana-68838	241	9	,	,	PUNCT
bibechana-68838	241	10	1871(1):64–74	1871(1):64–74	NUM
bibechana-68838	241	11	,	,	PUNCT
bibechana-68838	241	12	2019	2019	NUM
bibechana-68838	241	13	.	.	PUNCT
bibechana-68838	242	1	bidhya	bidhya	PROPN
bibechana-68838	242	2	thapa	thapa	PROPN
bibechana-68838	242	3	and	and	CCONJ
bibechana-68838	242	4	narayan	narayan	PROPN
bibechana-68838	242	5	prasad	prasad	PROPN
bibechana-68838	242	6	adhikari/	adhikari/	NUM
bibechana-68838	242	7	bibechana	bibechana	NOUN
bibechana-68838	242	8	21	21	NUM
bibechana-68838	242	9	(	(	PUNCT
bibechana-68838	242	10	2024	2024	NUM
bibechana-68838	242	11	)	)	PUNCT
bibechana-68838	242	12	290	290	NUM
bibechana-68838	242	13	-	-	SYM
bibechana-68838	242	14	299	299	NUM
bibechana-68838	242	15	298	298	NUM
bibechana-68838	242	16	[	[	X
bibechana-68838	242	17	8	8	NUM
bibechana-68838	242	18	]	]	X
bibechana-68838	242	19	a	a	DET
bibechana-68838	242	20	prokhortchouk	prokhortchouk	ADJ
bibechana-68838	242	21	et	et	NOUN
bibechana-68838	242	22	al	al	PROPN
bibechana-68838	242	23	.	.	PUNCT
bibechana-68838	243	1	the	the	DET
bibechana-68838	243	2	p120	p120	PROPN
bibechana-68838	243	3	catenin	catenin	NOUN
bibechana-68838	243	4	partner	partner	NOUN
bibechana-68838	243	5	kaiso	kaiso	NOUN
bibechana-68838	243	6	is	be	AUX
bibechana-68838	243	7	a	a	DET
bibechana-68838	243	8	dna	dna	PROPN
bibechana-68838	243	9	methylation	methylation	NOUN
bibechana-68838	243	10	-	-	PUNCT
bibechana-68838	243	11	dependent	dependent	ADJ
bibechana-68838	243	12	transcriptional	transcriptional	ADJ
bibechana-68838	243	13	repressor	repressor	NOUN
bibechana-68838	243	14	.	.	PUNCT
bibechana-68838	244	1	genes	gene	NOUN
bibechana-68838	244	2	&	&	CCONJ
bibechana-68838	244	3	development	development	NOUN
bibechana-68838	244	4	,	,	PUNCT
bibechana-68838	244	5	15(13):1613–1618	15(13):1613–1618	NUM
bibechana-68838	244	6	,	,	PUNCT
bibechana-68838	244	7	2001	2001	NUM
bibechana-68838	244	8	.	.	PUNCT
bibechana-68838	245	1	[	[	X
bibechana-68838	245	2	9	9	NUM
bibechana-68838	245	3	]	]	SYM
bibechana-68838	245	4	hg	hg	NOUN
bibechana-68838	245	5	yoon	yoon	PROPN
bibechana-68838	245	6	et	et	PROPN
bibechana-68838	245	7	al	al	PROPN
bibechana-68838	245	8	.	.	PROPN
bibechana-68838	245	9	n	n	CCONJ
bibechana-68838	245	10	-	-	PUNCT
bibechana-68838	245	11	cor	cor	NOUN
bibechana-68838	245	12	mediates	mediates	PROPN
bibechana-68838	245	13	dna	dna	PROPN
bibechana-68838	245	14	methylation	methylation	NOUN
bibechana-68838	245	15	-	-	PUNCT
bibechana-68838	245	16	dependent	dependent	ADJ
bibechana-68838	245	17	repression	repression	NOUN
bibechana-68838	245	18	through	through	ADP
bibechana-68838	245	19	a	a	DET
bibechana-68838	245	20	methyl	methyl	NOUN
bibechana-68838	245	21	cpg	cpg	NOUN
bibechana-68838	245	22	binding	bind	VERB
bibechana-68838	245	23	protein	protein	NOUN
bibechana-68838	245	24	kaiso	kaiso	NOUN
bibechana-68838	245	25	.	.	PUNCT
bibechana-68838	246	1	molecular	molecular	ADJ
bibechana-68838	246	2	cell	cell	NOUN
bibechana-68838	246	3	,	,	PUNCT
bibechana-68838	246	4	12(3):723–734	12(3):723–734	NUM
bibechana-68838	246	5	,	,	PUNCT
bibechana-68838	246	6	2003	2003	NUM
bibechana-68838	246	7	.	.	PUNCT
bibechana-68838	247	1	[	[	X
bibechana-68838	247	2	10	10	NUM
bibechana-68838	247	3	]	]	X
bibechana-68838	247	4	ns	ns	NUM
bibechana-68838	247	5	donaldson	donaldson	PROPN
bibechana-68838	247	6	et	et	PROPN
bibechana-68838	247	7	al	al	PROPN
bibechana-68838	247	8	.	.	PUNCT
bibechana-68838	247	9	kaiso	kaiso	PROPN
bibechana-68838	247	10	represses	repress	VERB
bibechana-68838	247	11	the	the	DET
bibechana-68838	247	12	cell	cell	NOUN
bibechana-68838	247	13	cycle	cycle	NOUN
bibechana-68838	247	14	gene	gene	NOUN
bibechana-68838	247	15	cyclin	cyclin	NOUN
bibechana-68838	247	16	d1	d1	PROPN
bibechana-68838	247	17	via	via	ADP
bibechana-68838	247	18	sequence	sequence	NOUN
bibechana-68838	247	19	-	-	PUNCT
bibechana-68838	247	20	specific	specific	ADJ
bibechana-68838	247	21	and	and	CCONJ
bibechana-68838	247	22	methyl	methyl	NOUN
bibechana-68838	247	23	-	-	PUNCT
bibechana-68838	247	24	cpg	cpg	NOUN
bibechana-68838	247	25	-	-	PUNCT
bibechana-68838	247	26	dependent	dependent	ADJ
bibechana-68838	247	27	mechanisms	mechanism	NOUN
bibechana-68838	247	28	.	.	PUNCT
bibechana-68838	248	1	plos	plos	PROPN
bibechana-68838	248	2	one	one	NUM
bibechana-68838	248	3	,	,	PUNCT
bibechana-68838	248	4	7(11):e50398	7(11):e50398	NUM
bibechana-68838	248	5	,	,	PUNCT
bibechana-68838	248	6	2012	2012	NUM
bibechana-68838	248	7	.	.	PUNCT
bibechana-68838	249	1	[	[	X
bibechana-68838	249	2	11	11	NUM
bibechana-68838	249	3	]	]	PUNCT
bibechana-68838	249	4	m.	m.	NOUN
bibechana-68838	249	5	rodova	rodova	PROPN
bibechana-68838	249	6	,	,	PUNCT
bibechana-68838	249	7	k.f	k.f	PROPN
bibechana-68838	249	8	.	.	PROPN
bibechana-68838	249	9	kelly	kelly	PROPN
bibechana-68838	249	10	,	,	PUNCT
bibechana-68838	249	11	m.	m.	NOUN
bibechana-68838	249	12	vansaun	vansaun	NOUN
bibechana-68838	249	13	,	,	PUNCT
bibechana-68838	249	14	j.m	j.m	PROPN
bibechana-68838	249	15	.	.	PROPN
bibechana-68838	249	16	daniel	daniel	PROPN
bibechana-68838	249	17	,	,	PUNCT
bibechana-68838	249	18	and	and	CCONJ
bibechana-68838	249	19	m.j	m.j	PROPN
bibechana-68838	249	20	.	.	PROPN
bibechana-68838	249	21	werle	werle	PROPN
bibechana-68838	249	22	.	.	PUNCT
bibechana-68838	250	1	regulation	regulation	NOUN
bibechana-68838	250	2	of	of	ADP
bibechana-68838	250	3	the	the	DET
bibechana-68838	250	4	rapsyn	rapsyn	NOUN
bibechana-68838	250	5	promoter	promoter	NOUN
bibechana-68838	250	6	by	by	ADP
bibechana-68838	250	7	kaiso	kaiso	NOUN
bibechana-68838	250	8	and	and	CCONJ
bibechana-68838	250	9	-catenin	-catenin	ADJ
bibechana-68838	250	10	.	.	PUNCT
bibechana-68838	251	1	molecular	molecular	ADJ
bibechana-68838	251	2	and	and	CCONJ
bibechana-68838	251	3	cellular	cellular	ADJ
bibechana-68838	251	4	biology	biology	NOUN
bibechana-68838	251	5	,	,	PUNCT
bibechana-68838	251	6	24(16):7188–7196	24(16):7188–7196	NUM
bibechana-68838	251	7	,	,	PUNCT
bibechana-68838	251	8	2004	2004	NUM
bibechana-68838	251	9	.	.	PUNCT
bibechana-68838	252	1	[	[	X
bibechana-68838	252	2	12	12	NUM
bibechana-68838	252	3	]	]	X
bibechana-68838	252	4	e.c	e.c	PROPN
bibechana-68838	252	5	.	.	PROPN
bibechana-68838	252	6	lopes	lopes	PROPN
bibechana-68838	252	7	,	,	PUNCT
bibechana-68838	252	8	e.	e.	PROPN
bibechana-68838	252	9	valls	valls	PROPN
bibechana-68838	252	10	,	,	PUNCT
bibechana-68838	252	11	m.e	m.e	PROPN
bibechana-68838	252	12	.	.	PROPN
bibechana-68838	252	13	figueroa	figueroa	PROPN
bibechana-68838	252	14	,	,	PUNCT
bibechana-68838	252	15	a.	a.	NOUN
bibechana-68838	252	16	mazur	mazur	PROPN
bibechana-68838	252	17	,	,	PUNCT
bibechana-68838	252	18	f.g	f.g	PROPN
bibechana-68838	252	19	.	.	PUNCT
bibechana-68838	252	20	meng	meng	PROPN
bibechana-68838	252	21	,	,	PUNCT
bibechana-68838	252	22	g.	g.	PROPN
bibechana-68838	252	23	chiosis	chiosis	PROPN
bibechana-68838	252	24	,	,	PUNCT
bibechana-68838	252	25	p.w	p.w	PROPN
bibechana-68838	252	26	.	.	PROPN
bibechana-68838	252	27	laird	laird	PROPN
bibechana-68838	252	28	,	,	PUNCT
bibechana-68838	252	29	w.	w.	PROPN
bibechana-68838	252	30	schüler	schüler	PROPN
bibechana-68838	252	31	,	,	PUNCT
bibechana-68838	252	32	s.m	s.m	PROPN
bibechana-68838	252	33	.	.	PROPN
bibechana-68838	252	34	lipkin	lipkin	PROPN
bibechana-68838	252	35	,	,	PUNCT
bibechana-68838	252	36	s.b	s.b	PROPN
bibechana-68838	252	37	.	.	PROPN
bibechana-68838	252	38	baylin	baylin	PROPN
bibechana-68838	252	39	,	,	PUNCT
bibechana-68838	252	40	et	et	PROPN
bibechana-68838	252	41	al	al	PROPN
bibechana-68838	252	42	.	.	PUNCT
bibechana-68838	252	43	kaiso	kaiso	PROPN
bibechana-68838	252	44	contributes	contribute	VERB
bibechana-68838	252	45	to	to	ADP
bibechana-68838	252	46	dna	dna	PROPN
bibechana-68838	252	47	methylationdependent	methylationdependent	NOUN
bibechana-68838	252	48	silencing	silence	VERB
bibechana-68838	252	49	of	of	ADP
bibechana-68838	252	50	tumor	tumor	NOUN
bibechana-68838	252	51	suppressor	suppressor	NOUN
bibechana-68838	252	52	genes	gene	NOUN
bibechana-68838	252	53	in	in	ADP
bibechana-68838	252	54	colon	colon	NOUN
bibechana-68838	252	55	cancer	cancer	NOUN
bibechana-68838	252	56	cell	cell	NOUN
bibechana-68838	252	57	lines	line	NOUN
bibechana-68838	252	58	.	.	PUNCT
bibechana-68838	253	1	cancer	cancer	NOUN
bibechana-68838	253	2	research	research	NOUN
bibechana-68838	253	3	,	,	PUNCT
bibechana-68838	253	4	68(18):7258–7263	68(18):7258–7263	NUM
bibechana-68838	253	5	,	,	PUNCT
bibechana-68838	253	6	2008	2008	NUM
bibechana-68838	253	7	.	.	PUNCT
bibechana-68838	254	1	[	[	X
bibechana-68838	254	2	13	13	NUM
bibechana-68838	254	3	]	]	X
bibechana-68838	254	4	h.	h.	PROPN
bibechana-68838	254	5	wang	wang	PROPN
bibechana-68838	254	6	,	,	PUNCT
bibechana-68838	254	7	g.	g.	PROPN
bibechana-68838	254	8	liu	liu	PROPN
bibechana-68838	254	9	,	,	PUNCT
bibechana-68838	254	10	d.	d.	PROPN
bibechana-68838	254	11	shen	shen	PROPN
bibechana-68838	254	12	,	,	PUNCT
bibechana-68838	254	13	h.	h.	PROPN
bibechana-68838	254	14	ye	ye	PROPN
bibechana-68838	254	15	,	,	PUNCT
bibechana-68838	254	16	j.	j.	PROPN
bibechana-68838	254	17	huang	huang	PROPN
bibechana-68838	254	18	,	,	PUNCT
bibechana-68838	254	19	h.	h.	PROPN
bibechana-68838	254	20	jiang	jiang	PROPN
bibechana-68838	254	21	,	,	PUNCT
bibechana-68838	254	22	and	and	CCONJ
bibechana-68838	254	23	j.	j.	PROPN
bibechana-68838	254	24	lu	lu	PROPN
bibechana-68838	254	25	.	.	PUNCT
bibechana-68838	255	1	kaiso	kaiso	PROPN
bibechana-68838	255	2	,	,	PUNCT
bibechana-68838	255	3	a	a	DET
bibechana-68838	255	4	transcriptional	transcriptional	ADJ
bibechana-68838	255	5	repressor	repressor	NOUN
bibechana-68838	255	6	,	,	PUNCT
bibechana-68838	255	7	promotes	promote	VERB
bibechana-68838	255	8	cell	cell	NOUN
bibechana-68838	255	9	migration	migration	NOUN
bibechana-68838	255	10	and	and	CCONJ
bibechana-68838	255	11	invasion	invasion	NOUN
bibechana-68838	255	12	of	of	ADP
bibechana-68838	255	13	prostate	prostate	NOUN
bibechana-68838	255	14	cancer	cancer	NOUN
bibechana-68838	255	15	cells	cell	NOUN
bibechana-68838	255	16	through	through	ADP
bibechana-68838	255	17	regulation	regulation	NOUN
bibechana-68838	255	18	of	of	ADP
bibechana-68838	255	19	mir-31	mir-31	NOUN
bibechana-68838	255	20	expression	expression	NOUN
bibechana-68838	255	21	.	.	PUNCT
bibechana-68838	256	1	oncotarget	oncotarget	NOUN
bibechana-68838	256	2	,	,	PUNCT
bibechana-68838	256	3	7(5):5677–5691	7(5):5677–5691	PROPN
bibechana-68838	256	4	,	,	PUNCT
bibechana-68838	256	5	2016	2016	NUM
bibechana-68838	256	6	.	.	PUNCT
bibechana-68838	257	1	[	[	X
bibechana-68838	257	2	14	14	NUM
bibechana-68838	257	3	]	]	X
bibechana-68838	257	4	s.j.b	s.j.b	NOUN
bibechana-68838	257	5	.	.	PUNCT
bibechana-68838	258	1	holwerda	holwerda	PROPN
bibechana-68838	258	2	and	and	CCONJ
bibechana-68838	258	3	w.	w.	PROPN
bibechana-68838	258	4	de	de	PROPN
bibechana-68838	258	5	laat	laat	PROPN
bibechana-68838	258	6	.	.	PUNCT
bibechana-68838	259	1	ctcf	ctcf	PROPN
bibechana-68838	259	2	:	:	PUNCT
bibechana-68838	259	3	the	the	DET
bibechana-68838	259	4	protein	protein	NOUN
bibechana-68838	259	5	,	,	PUNCT
bibechana-68838	259	6	the	the	DET
bibechana-68838	259	7	binding	bind	VERB
bibechana-68838	259	8	partners	partner	NOUN
bibechana-68838	259	9	,	,	PUNCT
bibechana-68838	259	10	the	the	DET
bibechana-68838	259	11	binding	bind	VERB
bibechana-68838	259	12	sites	site	NOUN
bibechana-68838	259	13	and	and	CCONJ
bibechana-68838	259	14	their	their	PRON
bibechana-68838	259	15	chromatin	chromatin	NOUN
bibechana-68838	259	16	loops	loop	NOUN
bibechana-68838	259	17	.	.	PUNCT
bibechana-68838	260	1	philosophical	philosophical	ADJ
bibechana-68838	260	2	transactions	transaction	NOUN
bibechana-68838	260	3	of	of	ADP
bibechana-68838	260	4	the	the	DET
bibechana-68838	260	5	royal	royal	ADJ
bibechana-68838	260	6	society	society	NOUN
bibechana-68838	260	7	b	b	PROPN
bibechana-68838	260	8	:	:	PUNCT
bibechana-68838	260	9	biological	biological	ADJ
bibechana-68838	260	10	sciences	science	NOUN
bibechana-68838	260	11	,	,	PUNCT
bibechana-68838	260	12	368(1620):20120369	368(1620):20120369	NUM
bibechana-68838	260	13	,	,	PUNCT
bibechana-68838	260	14	2013	2013	NUM
bibechana-68838	260	15	.	.	PUNCT
bibechana-68838	261	1	[	[	X
bibechana-68838	261	2	15	15	NUM
bibechana-68838	261	3	]	]	X
bibechana-68838	261	4	y.	y.	PROPN
bibechana-68838	261	5	shen	shen	PROPN
bibechana-68838	261	6	,	,	PUNCT
bibechana-68838	261	7	f.	f.	PROPN
bibechana-68838	261	8	yue	yue	PROPN
bibechana-68838	261	9	,	,	PUNCT
bibechana-68838	261	10	d.f	d.f	PROPN
bibechana-68838	261	11	.	.	PROPN
bibechana-68838	261	12	mccleary	mccleary	PROPN
bibechana-68838	261	13	,	,	PUNCT
bibechana-68838	261	14	z.	z.	PROPN
bibechana-68838	261	15	ye	ye	PROPN
bibechana-68838	261	16	,	,	PUNCT
bibechana-68838	261	17	l.	l.	PROPN
bibechana-68838	261	18	edsall	edsall	PROPN
bibechana-68838	261	19	,	,	PUNCT
bibechana-68838	261	20	s.	s.	PROPN
bibechana-68838	261	21	kuan	kuan	PROPN
bibechana-68838	261	22	,	,	PUNCT
bibechana-68838	261	23	u.	u.	PROPN
bibechana-68838	261	24	wagner	wagner	PROPN
bibechana-68838	261	25	,	,	PUNCT
bibechana-68838	261	26	j.	j.	PROPN
bibechana-68838	261	27	dixon	dixon	PROPN
bibechana-68838	261	28	,	,	PUNCT
bibechana-68838	261	29	l.	l.	PROPN
bibechana-68838	261	30	lee	lee	PROPN
bibechana-68838	261	31	,	,	PUNCT
bibechana-68838	261	32	v.v	v.v	PROPN
bibechana-68838	261	33	.	.	PROPN
bibechana-68838	261	34	lobanenkov	lobanenkov	PROPN
bibechana-68838	261	35	,	,	PUNCT
bibechana-68838	261	36	et	et	PROPN
bibechana-68838	261	37	al	al	PROPN
bibechana-68838	261	38	.	.	PUNCT
bibechana-68838	262	1	a	a	DET
bibechana-68838	262	2	map	map	NOUN
bibechana-68838	262	3	of	of	ADP
bibechana-68838	262	4	the	the	DET
bibechana-68838	262	5	cisregulatory	cisregulatory	ADJ
bibechana-68838	262	6	sequences	sequence	NOUN
bibechana-68838	262	7	in	in	ADP
bibechana-68838	262	8	the	the	DET
bibechana-68838	262	9	mouse	mouse	NOUN
bibechana-68838	262	10	genome	genome	NOUN
bibechana-68838	262	11	.	.	PUNCT
bibechana-68838	263	1	nature	nature	NOUN
bibechana-68838	263	2	,	,	PUNCT
bibechana-68838	263	3	488(7409):116–120	488(7409):116–120	NUM
bibechana-68838	263	4	,	,	PUNCT
bibechana-68838	263	5	2012	2012	NUM
bibechana-68838	263	6	.	.	PUNCT
bibechana-68838	264	1	[	[	X
bibechana-68838	264	2	16	16	NUM
bibechana-68838	264	3	]	]	X
bibechana-68838	264	4	h.	h.	PROPN
bibechana-68838	264	5	wang	wang	PROPN
bibechana-68838	264	6	,	,	PUNCT
bibechana-68838	264	7	m.t	m.t	PROPN
bibechana-68838	264	8	.	.	PROPN
bibechana-68838	264	9	maurano	maurano	PROPN
bibechana-68838	264	10	,	,	PUNCT
bibechana-68838	264	11	h.	h.	PROPN
bibechana-68838	264	12	qu	qu	PROPN
bibechana-68838	264	13	,	,	PUNCT
bibechana-68838	264	14	k.e	k.e	PROPN
bibechana-68838	264	15	.	.	PROPN
bibechana-68838	264	16	varley	varley	PROPN
bibechana-68838	264	17	,	,	PUNCT
bibechana-68838	264	18	j.	j.	PROPN
bibechana-68838	264	19	gertz	gertz	PROPN
bibechana-68838	264	20	,	,	PUNCT
bibechana-68838	264	21	f.	f.	PROPN
bibechana-68838	264	22	pauli	pauli	PROPN
bibechana-68838	264	23	,	,	PUNCT
bibechana-68838	264	24	k.	k.	PROPN
bibechana-68838	264	25	lee	lee	PROPN
bibechana-68838	264	26	,	,	PUNCT
bibechana-68838	264	27	t.	t.	PROPN
bibechana-68838	264	28	canfield	canfield	PROPN
bibechana-68838	264	29	,	,	PUNCT
bibechana-68838	264	30	m.	m.	NOUN
bibechana-68838	264	31	weaver	weaver	PROPN
bibechana-68838	264	32	,	,	PUNCT
bibechana-68838	264	33	r.	r.	PROPN
bibechana-68838	264	34	sandstrom	sandstrom	PROPN
bibechana-68838	264	35	,	,	PUNCT
bibechana-68838	264	36	et	et	PROPN
bibechana-68838	264	37	al	al	PROPN
bibechana-68838	264	38	.	.	PROPN
bibechana-68838	265	1	widespread	widespread	ADJ
bibechana-68838	265	2	plasticity	plasticity	NOUN
bibechana-68838	265	3	in	in	ADP
bibechana-68838	265	4	ctcf	ctcf	ADJ
bibechana-68838	265	5	occupancy	occupancy	NOUN
bibechana-68838	265	6	linked	link	VERB
bibechana-68838	265	7	to	to	ADP
bibechana-68838	265	8	dna	dna	PROPN
bibechana-68838	265	9	methylation	methylation	NOUN
bibechana-68838	265	10	.	.	PUNCT
bibechana-68838	266	1	genome	genome	NOUN
bibechana-68838	266	2	research	research	NOUN
bibechana-68838	266	3	,	,	PUNCT
bibechana-68838	266	4	22(9):1680	22(9):1680	NUM
bibechana-68838	266	5	–	–	PUNCT
bibechana-68838	266	6	1688	1688	NUM
bibechana-68838	266	7	,	,	PUNCT
bibechana-68838	266	8	2012	2012	NUM
bibechana-68838	266	9	.	.	PUNCT
bibechana-68838	267	1	[	[	X
bibechana-68838	267	2	17	17	NUM
bibechana-68838	267	3	]	]	X
bibechana-68838	267	4	e.m	e.m	PROPN
bibechana-68838	267	5	.	.	PROPN
bibechana-68838	267	6	klenova	klenova	PROPN
bibechana-68838	267	7	,	,	PUNCT
bibechana-68838	267	8	r.h	r.h	PROPN
bibechana-68838	267	9	.	.	PROPN
bibechana-68838	267	10	nicolas	nicolas	PROPN
bibechana-68838	267	11	,	,	PUNCT
bibechana-68838	267	12	h.f	h.f	PROPN
bibechana-68838	267	13	.	.	PROPN
bibechana-68838	267	14	paterson	paterson	PROPN
bibechana-68838	267	15	,	,	PUNCT
bibechana-68838	267	16	a.f	a.f	PROPN
bibechana-68838	267	17	.	.	PROPN
bibechana-68838	267	18	carne	carne	PROPN
bibechana-68838	267	19	,	,	PUNCT
bibechana-68838	267	20	c.m	c.m	PROPN
bibechana-68838	267	21	.	.	PROPN
bibechana-68838	267	22	heath	heath	PROPN
bibechana-68838	267	23	,	,	PUNCT
bibechana-68838	267	24	g.h	g.h	PROPN
bibechana-68838	267	25	.	.	PROPN
bibechana-68838	267	26	goodwin	goodwin	PROPN
bibechana-68838	267	27	,	,	PUNCT
bibechana-68838	267	28	p.e	p.e	PROPN
bibechana-68838	267	29	.	.	PROPN
bibechana-68838	267	30	neiman	neiman	PROPN
bibechana-68838	267	31	,	,	PUNCT
bibechana-68838	267	32	and	and	CCONJ
bibechana-68838	267	33	v.v	v.v	PROPN
bibechana-68838	267	34	.	.	PROPN
bibechana-68838	267	35	lobanenkov	lobanenkov	PROPN
bibechana-68838	267	36	.	.	PUNCT
bibechana-68838	268	1	ctcf	ctcf	PROPN
bibechana-68838	268	2	,	,	PUNCT
bibechana-68838	268	3	a	a	DET
bibechana-68838	268	4	conserved	conserve	VERB
bibechana-68838	268	5	nuclear	nuclear	ADJ
bibechana-68838	268	6	factor	factor	NOUN
bibechana-68838	268	7	required	require	VERB
bibechana-68838	268	8	for	for	ADP
bibechana-68838	268	9	optimal	optimal	ADJ
bibechana-68838	268	10	transcriptional	transcriptional	ADJ
bibechana-68838	268	11	activity	activity	NOUN
bibechana-68838	268	12	of	of	ADP
bibechana-68838	268	13	the	the	DET
bibechana-68838	268	14	chicken	chicken	NOUN
bibechana-68838	268	15	c	c	PROPN
bibechana-68838	268	16	-	-	PUNCT
bibechana-68838	268	17	myc	myc	NOUN
bibechana-68838	268	18	gene	gene	NOUN
bibechana-68838	268	19	,	,	PUNCT
bibechana-68838	268	20	is	be	AUX
bibechana-68838	268	21	an	an	DET
bibechana-68838	268	22	11	11	NUM
bibechana-68838	268	23	-	-	PUNCT
bibechana-68838	268	24	zn	zn	NOUN
bibechana-68838	268	25	-	-	PUNCT
bibechana-68838	268	26	finger	finger	NOUN
bibechana-68838	268	27	protein	protein	NOUN
bibechana-68838	268	28	differentially	differentially	ADV
bibechana-68838	268	29	expressed	express	VERB
bibechana-68838	268	30	in	in	ADP
bibechana-68838	268	31	multiple	multiple	ADJ
bibechana-68838	268	32	forms	form	NOUN
bibechana-68838	268	33	.	.	PUNCT
bibechana-68838	269	1	molecular	molecular	ADJ
bibechana-68838	269	2	and	and	CCONJ
bibechana-68838	269	3	cellular	cellular	ADJ
bibechana-68838	269	4	biology	biology	NOUN
bibechana-68838	269	5	,	,	PUNCT
bibechana-68838	269	6	13(10):7091–7101	13(10):7091–7101	NUM
bibechana-68838	269	7	,	,	PUNCT
bibechana-68838	269	8	1993	1993	NUM
bibechana-68838	269	9	.	.	PUNCT
bibechana-68838	270	1	[	[	X
bibechana-68838	270	2	18	18	NUM
bibechana-68838	270	3	]	]	X
bibechana-68838	270	4	m.m	m.m	PROPN
bibechana-68838	270	5	.	.	PROPN
bibechana-68838	270	6	franco	franco	PROPN
bibechana-68838	270	7	,	,	PUNCT
bibechana-68838	270	8	a.r	a.r	PROPN
bibechana-68838	270	9	.	.	PROPN
bibechana-68838	270	10	prickett	prickett	PROPN
bibechana-68838	270	11	,	,	PUNCT
bibechana-68838	270	12	and	and	CCONJ
bibechana-68838	270	13	r.j	r.j	PROPN
bibechana-68838	270	14	.	.	PROPN
bibechana-68838	270	15	oakey	oakey	PROPN
bibechana-68838	270	16	.	.	PUNCT
bibechana-68838	271	1	the	the	DET
bibechana-68838	271	2	role	role	NOUN
bibechana-68838	271	3	of	of	ADP
bibechana-68838	271	4	ccctc	ccctc	NOUN
bibechana-68838	271	5	-	-	PUNCT
bibechana-68838	271	6	binding	bind	VERB
bibechana-68838	271	7	factor	factor	NOUN
bibechana-68838	271	8	(	(	PUNCT
bibechana-68838	271	9	ctcf	ctcf	ADJ
bibechana-68838	271	10	)	)	PUNCT
bibechana-68838	271	11	in	in	ADP
bibechana-68838	271	12	genomic	genomic	ADJ
bibechana-68838	271	13	imprinting	imprinting	NOUN
bibechana-68838	271	14	,	,	PUNCT
bibechana-68838	271	15	development	development	NOUN
bibechana-68838	271	16	,	,	PUNCT
bibechana-68838	271	17	and	and	CCONJ
bibechana-68838	271	18	reproduction	reproduction	NOUN
bibechana-68838	271	19	.	.	PUNCT
bibechana-68838	272	1	biology	biology	NOUN
bibechana-68838	272	2	of	of	ADP
bibechana-68838	272	3	reproduction	reproduction	NOUN
bibechana-68838	272	4	,	,	PUNCT
bibechana-68838	272	5	91(5):125	91(5):125	NUM
bibechana-68838	272	6	,	,	PUNCT
bibechana-68838	272	7	1–9	1–9	NUM
bibechana-68838	272	8	,	,	PUNCT
bibechana-68838	272	9	2014	2014	NUM
bibechana-68838	272	10	.	.	PUNCT
bibechana-68838	273	1	[	[	X
bibechana-68838	273	2	19	19	NUM
bibechana-68838	273	3	]	]	X
bibechana-68838	273	4	m.	m.	NOUN
bibechana-68838	273	5	renda	renda	PROPN
bibechana-68838	273	6	,	,	PUNCT
bibechana-68838	273	7	i.	i.	PROPN
bibechana-68838	273	8	baglivo	baglivo	PROPN
bibechana-68838	273	9	,	,	PUNCT
bibechana-68838	273	10	b.	b.	PROPN
bibechana-68838	273	11	burgess	burgess	PROPN
bibechana-68838	273	12	-	-	PUNCT
bibechana-68838	273	13	beusse	beusse	PROPN
bibechana-68838	273	14	,	,	PUNCT
bibechana-68838	273	15	s.	s.	PROPN
bibechana-68838	273	16	esposito	esposito	PROPN
bibechana-68838	273	17	,	,	PUNCT
bibechana-68838	273	18	r.	r.	PROPN
bibechana-68838	273	19	fattorusso	fattorusso	PROPN
bibechana-68838	273	20	,	,	PUNCT
bibechana-68838	273	21	g.	g.	PROPN
bibechana-68838	273	22	felsenfeld	felsenfeld	PROPN
bibechana-68838	273	23	,	,	PUNCT
bibechana-68838	273	24	and	and	CCONJ
bibechana-68838	273	25	p.v	p.v	PROPN
bibechana-68838	273	26	.	.	PROPN
bibechana-68838	273	27	pedone	pedone	PROPN
bibechana-68838	273	28	.	.	PUNCT
bibechana-68838	274	1	critical	critical	ADJ
bibechana-68838	274	2	dna	dna	NOUN
bibechana-68838	274	3	binding	bind	VERB
bibechana-68838	274	4	interactions	interaction	NOUN
bibechana-68838	274	5	of	of	ADP
bibechana-68838	274	6	the	the	DET
bibechana-68838	274	7	insulator	insulator	NOUN
bibechana-68838	274	8	protein	protein	NOUN
bibechana-68838	274	9	ctcf	ctcf	ADJ
bibechana-68838	274	10	:	:	PUNCT
bibechana-68838	274	11	a	a	DET
bibechana-68838	274	12	small	small	ADJ
bibechana-68838	274	13	number	number	NOUN
bibechana-68838	274	14	of	of	ADP
bibechana-68838	274	15	zinc	zinc	NOUN
bibechana-68838	274	16	fingers	finger	NOUN
bibechana-68838	274	17	mediate	mediate	VERB
bibechana-68838	274	18	strong	strong	ADJ
bibechana-68838	274	19	binding	bind	VERB
bibechana-68838	274	20	,	,	PUNCT
bibechana-68838	274	21	and	and	CCONJ
bibechana-68838	274	22	a	a	DET
bibechana-68838	274	23	single	single	ADJ
bibechana-68838	274	24	finger	finger	NOUN
bibechana-68838	274	25	-	-	PUNCT
bibechana-68838	274	26	dna	dna	NOUN
bibechana-68838	274	27	interaction	interaction	NOUN
bibechana-68838	274	28	controls	control	VERB
bibechana-68838	274	29	binding	bind	VERB
bibechana-68838	274	30	at	at	ADP
bibechana-68838	274	31	imprinted	imprinted	ADJ
bibechana-68838	274	32	loci	locus	NOUN
bibechana-68838	274	33	.	.	PUNCT
bibechana-68838	275	1	journal	journal	PROPN
bibechana-68838	275	2	of	of	ADP
bibechana-68838	275	3	biological	biological	ADJ
bibechana-68838	275	4	chemistry	chemistry	NOUN
bibechana-68838	275	5	,	,	PUNCT
bibechana-68838	275	6	282(46):33336–33345	282(46):33336–33345	NUM
bibechana-68838	275	7	,	,	PUNCT
bibechana-68838	275	8	2007	2007	NUM
bibechana-68838	275	9	.	.	PUNCT
bibechana-68838	276	1	[	[	X
bibechana-68838	276	2	20	20	NUM
bibechana-68838	276	3	]	]	X
bibechana-68838	276	4	t.h	t.h	PROPN
bibechana-68838	276	5	.	.	PUNCT
bibechana-68838	276	6	kim	kim	PROPN
bibechana-68838	276	7	,	,	PUNCT
bibechana-68838	276	8	z.k	z.k	PROPN
bibechana-68838	276	9	.	.	PROPN
bibechana-68838	276	10	abdullaev	abdullaev	PROPN
bibechana-68838	276	11	,	,	PUNCT
bibechana-68838	276	12	a.d	a.d	PROPN
bibechana-68838	276	13	.	.	PROPN
bibechana-68838	276	14	smith	smith	PROPN
bibechana-68838	276	15	,	,	PUNCT
bibechana-68838	276	16	k.a	k.a	PROPN
bibechana-68838	276	17	.	.	PUNCT
bibechana-68838	277	1	ching	ching	PROPN
bibechana-68838	277	2	,	,	PUNCT
bibechana-68838	277	3	d.i	d.i	PROPN
bibechana-68838	277	4	.	.	PROPN
bibechana-68838	277	5	loukinov	loukinov	PROPN
bibechana-68838	277	6	,	,	PUNCT
bibechana-68838	277	7	r.d	r.d	PROPN
bibechana-68838	277	8	.	.	PROPN
bibechana-68838	277	9	green	green	PROPN
bibechana-68838	277	10	,	,	PUNCT
bibechana-68838	277	11	m.q	m.q	PROPN
bibechana-68838	277	12	.	.	PROPN
bibechana-68838	277	13	zhang	zhang	PROPN
bibechana-68838	277	14	,	,	PUNCT
bibechana-68838	277	15	v.v	v.v	PROPN
bibechana-68838	277	16	.	.	PROPN
bibechana-68838	277	17	lobanenkov	lobanenkov	PROPN
bibechana-68838	277	18	,	,	PUNCT
bibechana-68838	277	19	and	and	CCONJ
bibechana-68838	277	20	b.	b.	PROPN
bibechana-68838	277	21	ren	ren	PROPN
bibechana-68838	277	22	.	.	PUNCT
bibechana-68838	278	1	analysis	analysis	NOUN
bibechana-68838	278	2	of	of	ADP
bibechana-68838	278	3	the	the	DET
bibechana-68838	278	4	vertebrate	vertebrate	ADJ
bibechana-68838	278	5	insulator	insulator	NOUN
bibechana-68838	278	6	protein	protein	NOUN
bibechana-68838	278	7	ctcfbinding	ctcfbinde	VERB
bibechana-68838	278	8	sites	site	NOUN
bibechana-68838	278	9	in	in	ADP
bibechana-68838	278	10	the	the	DET
bibechana-68838	278	11	human	human	ADJ
bibechana-68838	278	12	genome	genome	NOUN
bibechana-68838	278	13	.	.	PUNCT
bibechana-68838	279	1	cell	cell	NOUN
bibechana-68838	279	2	,	,	PUNCT
bibechana-68838	279	3	128(6):1231–1245	128(6):1231–1245	PROPN
bibechana-68838	279	4	,	,	PUNCT
bibechana-68838	279	5	2007	2007	NUM
bibechana-68838	279	6	.	.	PUNCT
bibechana-68838	280	1	[	[	X
bibechana-68838	280	2	21	21	NUM
bibechana-68838	280	3	]	]	X
bibechana-68838	280	4	v.	v.	X
bibechana-68838	280	5	lobanenkov	lobanenkov	PROPN
bibechana-68838	280	6	,	,	PUNCT
bibechana-68838	280	7	r.h	r.h	PROPN
bibechana-68838	280	8	.	.	PROPN
bibechana-68838	280	9	nicolas	nicolas	PROPN
bibechana-68838	280	10	,	,	PUNCT
bibechana-68838	280	11	h.	h.	PROPN
bibechana-68838	280	12	paterson	paterson	PROPN
bibechana-68838	280	13	,	,	PUNCT
bibechana-68838	280	14	p.	p.	PROPN
bibechana-68838	280	15	de	de	PROPN
bibechana-68838	280	16	jong	jong	PROPN
bibechana-68838	280	17	,	,	PUNCT
bibechana-68838	280	18	g.h	g.h	PROPN
bibechana-68838	280	19	.	.	PROPN
bibechana-68838	280	20	goodwin	goodwin	PROPN
bibechana-68838	280	21	,	,	PUNCT
bibechana-68838	280	22	v.v	v.v	PROPN
bibechana-68838	280	23	.	.	PROPN
bibechana-68838	280	24	lobanenkov	lobanenkov	PROPN
bibechana-68838	280	25	,	,	PUNCT
bibechana-68838	280	26	g.p	g.p	PROPN
bibechana-68838	280	27	.	.	PROPN
bibechana-68838	280	28	lomonossoff	lomonossoff	PROPN
bibechana-68838	280	29	,	,	PUNCT
bibechana-68838	280	30	and	and	CCONJ
bibechana-68838	280	31	p.e	p.e	PROPN
bibechana-68838	280	32	.	.	PROPN
bibechana-68838	280	33	neiman	neiman	PROPN
bibechana-68838	280	34	.	.	PUNCT
bibechana-68838	281	1	a	a	DET
bibechana-68838	281	2	novel	novel	ADJ
bibechana-68838	281	3	sequence	sequence	NOUN
bibechana-68838	281	4	-	-	PUNCT
bibechana-68838	281	5	specific	specific	ADJ
bibechana-68838	281	6	dna	dna	NOUN
bibechana-68838	281	7	binding	bind	VERB
bibechana-68838	281	8	protein	protein	NOUN
bibechana-68838	281	9	which	which	PRON
bibechana-68838	281	10	interacts	interact	VERB
bibechana-68838	281	11	with	with	ADP
bibechana-68838	281	12	three	three	NUM
bibechana-68838	281	13	regularly	regularly	ADV
bibechana-68838	281	14	spaced	space	VERB
bibechana-68838	281	15	direct	direct	ADJ
bibechana-68838	281	16	repeats	repeat	NOUN
bibechana-68838	281	17	of	of	ADP
bibechana-68838	281	18	the	the	DET
bibechana-68838	281	19	ccctc	ccctc	NOUN
bibechana-68838	281	20	-	-	PUNCT
bibechana-68838	281	21	motif	motif	NOUN
bibechana-68838	281	22	in	in	ADP
bibechana-68838	281	23	the	the	DET
bibechana-68838	281	24	5	5	NUM
bibechana-68838	281	25	-	-	PUNCT
bibechana-68838	281	26	flanking	flank	VERB
bibechana-68838	281	27	sequence	sequence	NOUN
bibechana-68838	281	28	of	of	ADP
bibechana-68838	281	29	the	the	DET
bibechana-68838	281	30	chicken	chicken	NOUN
bibechana-68838	281	31	c	c	PROPN
bibechana-68838	281	32	-	-	PUNCT
bibechana-68838	281	33	myc	myc	NOUN
bibechana-68838	281	34	gene	gene	NOUN
bibechana-68838	281	35	.	.	PUNCT
bibechana-68838	282	1	oncogene	oncogene	NOUN
bibechana-68838	282	2	,	,	PUNCT
bibechana-68838	282	3	5(12):1743–1753	5(12):1743–1753	NUM
bibechana-68838	282	4	,	,	PUNCT
bibechana-68838	282	5	1990	1990	NUM
bibechana-68838	282	6	.	.	PUNCT
bibechana-68838	283	1	[	[	X
bibechana-68838	283	2	22	22	NUM
bibechana-68838	283	3	]	]	X
bibechana-68838	283	4	a.c	a.c	PROPN
bibechana-68838	283	5	.	.	PROPN
bibechana-68838	283	6	bell	bell	PROPN
bibechana-68838	283	7	,	,	PUNCT
bibechana-68838	283	8	a.g	a.g	PROPN
bibechana-68838	283	9	.	.	PROPN
bibechana-68838	283	10	west	west	PROPN
bibechana-68838	283	11	,	,	PUNCT
bibechana-68838	283	12	and	and	CCONJ
bibechana-68838	283	13	g.	g.	PROPN
bibechana-68838	283	14	felsenfeld	felsenfeld	PROPN
bibechana-68838	283	15	.	.	PUNCT
bibechana-68838	284	1	the	the	DET
bibechana-68838	284	2	protein	protein	NOUN
bibechana-68838	284	3	ctcf	ctcf	NOUN
bibechana-68838	284	4	is	be	AUX
bibechana-68838	284	5	required	require	VERB
bibechana-68838	284	6	for	for	ADP
bibechana-68838	284	7	the	the	DET
bibechana-68838	284	8	enhancer	enhancer	NOUN
bibechana-68838	284	9	blocking	block	VERB
bibechana-68838	284	10	activity	activity	NOUN
bibechana-68838	284	11	of	of	ADP
bibechana-68838	284	12	vertebrate	vertebrate	ADJ
bibechana-68838	284	13	insulators	insulator	NOUN
bibechana-68838	284	14	.	.	PUNCT
bibechana-68838	285	1	cell	cell	NOUN
bibechana-68838	285	2	,	,	PUNCT
bibechana-68838	285	3	98(3):387–396	98(3):387–396	NUM
bibechana-68838	285	4	,	,	PUNCT
bibechana-68838	285	5	1999	1999	NUM
bibechana-68838	285	6	.	.	PUNCT
bibechana-68838	286	1	[	[	X
bibechana-68838	286	2	23	23	NUM
bibechana-68838	286	3	]	]	X
bibechana-68838	286	4	a.t	a.t	PROPN
bibechana-68838	286	5	.	.	PROPN
bibechana-68838	286	6	hark	hark	PROPN
bibechana-68838	286	7	,	,	PUNCT
bibechana-68838	286	8	c.j	c.j	PROPN
bibechana-68838	286	9	.	.	PROPN
bibechana-68838	286	10	schoenherr	schoenherr	NOUN
bibechana-68838	286	11	,	,	PUNCT
bibechana-68838	286	12	d.j	d.j	PROPN
bibechana-68838	286	13	.	.	PROPN
bibechana-68838	286	14	katz	katz	PROPN
bibechana-68838	286	15	,	,	PUNCT
bibechana-68838	286	16	r.s	r.s	PROPN
bibechana-68838	286	17	.	.	PROPN
bibechana-68838	286	18	ingram	ingram	PROPN
bibechana-68838	286	19	,	,	PUNCT
bibechana-68838	286	20	j.m	j.m	PROPN
bibechana-68838	286	21	.	.	PROPN
bibechana-68838	286	22	levorse	levorse	PROPN
bibechana-68838	286	23	,	,	PUNCT
bibechana-68838	286	24	and	and	CCONJ
bibechana-68838	286	25	s.m	s.m	PROPN
bibechana-68838	286	26	.	.	PROPN
bibechana-68838	286	27	tilghman	tilghman	PROPN
bibechana-68838	286	28	.	.	PROPN
bibechana-68838	287	1	ctcf	ctcf	PROPN
bibechana-68838	287	2	mediates	mediate	NOUN
bibechana-68838	287	3	methylation	methylation	NOUN
bibechana-68838	287	4	-	-	PUNCT
bibechana-68838	287	5	sensitive	sensitive	ADJ
bibechana-68838	287	6	enhancerblocking	enhancerblocke	VERB
bibechana-68838	287	7	activity	activity	NOUN
bibechana-68838	287	8	at	at	ADP
bibechana-68838	287	9	the	the	DET
bibechana-68838	287	10	h19	h19	PROPN
bibechana-68838	287	11	/	/	SYM
bibechana-68838	287	12	igf2	igf2	PROPN
bibechana-68838	287	13	locus	locus	NOUN
bibechana-68838	287	14	.	.	PUNCT
bibechana-68838	288	1	nature	nature	NOUN
bibechana-68838	288	2	,	,	PUNCT
bibechana-68838	288	3	405(6785):486–489	405(6785):486–489	NUM
bibechana-68838	288	4	,	,	PUNCT
bibechana-68838	288	5	2000	2000	NUM
bibechana-68838	288	6	.	.	PUNCT
bibechana-68838	289	1	[	[	X
bibechana-68838	289	2	24	24	NUM
bibechana-68838	289	3	]	]	SYM
bibechana-68838	289	4	a.c	a.c	PROPN
bibechana-68838	289	5	.	.	PROPN
bibechana-68838	289	6	bell	bell	PROPN
bibechana-68838	289	7	and	and	CCONJ
bibechana-68838	289	8	g.	g.	PROPN
bibechana-68838	289	9	felsenfeld	felsenfeld	PROPN
bibechana-68838	289	10	.	.	PUNCT
bibechana-68838	290	1	methylation	methylation	NOUN
bibechana-68838	290	2	of	of	ADP
bibechana-68838	290	3	a	a	DET
bibechana-68838	290	4	ctcf	ctcf	ADJ
bibechana-68838	290	5	-	-	PUNCT
bibechana-68838	290	6	dependent	dependent	ADJ
bibechana-68838	290	7	boundary	boundary	ADJ
bibechana-68838	290	8	controls	control	NOUN
bibechana-68838	290	9	imprinted	imprint	VERB
bibechana-68838	290	10	expression	expression	NOUN
bibechana-68838	290	11	of	of	ADP
bibechana-68838	290	12	the	the	DET
bibechana-68838	290	13	igf2	igf2	PROPN
bibechana-68838	290	14	gene	gene	NOUN
bibechana-68838	290	15	.	.	PUNCT
bibechana-68838	291	1	nature	nature	NOUN
bibechana-68838	291	2	,	,	PUNCT
bibechana-68838	291	3	405(6785):482–485	405(6785):482–485	NUM
bibechana-68838	291	4	,	,	PUNCT
bibechana-68838	291	5	2000	2000	NUM
bibechana-68838	291	6	.	.	PUNCT
bibechana-68838	292	1	[	[	X
bibechana-68838	292	2	25	25	NUM
bibechana-68838	292	3	]	]	PUNCT
bibechana-68838	292	4	p.-a	p.-a	NOUN
bibechana-68838	292	5	.	.	PUNCT
bibechana-68838	293	1	defossez	defossez	PROPN
bibechana-68838	293	2	,	,	PUNCT
bibechana-68838	293	3	k.f	k.f	PROPN
bibechana-68838	293	4	.	.	PROPN
bibechana-68838	293	5	kelly	kelly	PROPN
bibechana-68838	293	6	,	,	PUNCT
bibechana-68838	293	7	g.j	g.j	PROPN
bibechana-68838	293	8	.	.	PROPN
bibechana-68838	293	9	filion	filion	NOUN
bibechana-68838	293	10	,	,	PUNCT
bibechana-68838	293	11	r.	r.	PROPN
bibechana-68838	293	12	perez	perez	PROPN
bibechana-68838	293	13	-	-	PUNCT
bibechana-68838	293	14	torrado	torrado	PROPN
bibechana-68838	293	15	,	,	PUNCT
bibechana-68838	293	16	f.	f.	PROPN
bibechana-68838	293	17	magdinier	magdinier	PROPN
bibechana-68838	293	18	,	,	PUNCT
bibechana-68838	293	19	h.	h.	PROPN
bibechana-68838	293	20	menoni	menoni	PROPN
bibechana-68838	293	21	,	,	PUNCT
bibechana-68838	293	22	c.l	c.l	PROPN
bibechana-68838	293	23	.	.	PROPN
bibechana-68838	293	24	nordgaard	nordgaard	PROPN
bibechana-68838	293	25	,	,	PUNCT
bibechana-68838	293	26	j.m	j.m	PROPN
bibechana-68838	293	27	.	.	PROPN
bibechana-68838	293	28	daniel	daniel	PROPN
bibechana-68838	293	29	,	,	PUNCT
bibechana-68838	293	30	and	and	CCONJ
bibechana-68838	293	31	e.	e.	PROPN
bibechana-68838	293	32	gilson	gilson	PROPN
bibechana-68838	293	33	.	.	PUNCT
bibechana-68838	294	1	the	the	DET
bibechana-68838	294	2	human	human	ADJ
bibechana-68838	294	3	enhancer	enhancer	PROPN
bibechana-68838	294	4	blocker	blocker	NOUN
bibechana-68838	294	5	ctc	ctc	NOUN
bibechana-68838	294	6	-	-	PUNCT
bibechana-68838	294	7	binding	bind	VERB
bibechana-68838	294	8	factor	factor	NOUN
bibechana-68838	294	9	interacts	interact	VERB
bibechana-68838	294	10	with	with	ADP
bibechana-68838	294	11	the	the	DET
bibechana-68838	294	12	transcription	transcription	NOUN
bibechana-68838	294	13	factor	factor	NOUN
bibechana-68838	294	14	kaiso	kaiso	NOUN
bibechana-68838	294	15	.	.	PUNCT
bibechana-68838	295	1	journal	journal	PROPN
bibechana-68838	295	2	of	of	ADP
bibechana-68838	295	3	biological	biological	ADJ
bibechana-68838	295	4	chemistry	chemistry	NOUN
bibechana-68838	295	5	,	,	PUNCT
bibechana-68838	295	6	280(52):43017–43023	280(52):43017–43023	NUM
bibechana-68838	295	7	,	,	PUNCT
bibechana-68838	295	8	2005	2005	NUM
bibechana-68838	295	9	.	.	PUNCT
bibechana-68838	296	1	[	[	X
bibechana-68838	296	2	26	26	NUM
bibechana-68838	296	3	]	]	X
bibechana-68838	296	4	g.n	g.n	PROPN
bibechana-68838	296	5	.	.	PROPN
bibechana-68838	296	6	filippova	filippova	PROPN
bibechana-68838	296	7	,	,	PUNCT
bibechana-68838	296	8	s.	s.	PROPN
bibechana-68838	296	9	fagerlie	fagerlie	PROPN
bibechana-68838	296	10	,	,	PUNCT
bibechana-68838	296	11	e.m	e.m	PROPN
bibechana-68838	296	12	.	.	PROPN
bibechana-68838	296	13	klenova	klenova	PROPN
bibechana-68838	296	14	,	,	PUNCT
bibechana-68838	296	15	c.	c.	PROPN
bibechana-68838	296	16	myers	myers	PROPN
bibechana-68838	296	17	,	,	PUNCT
bibechana-68838	296	18	y.	y.	PROPN
bibechana-68838	296	19	dehner	dehner	PROPN
bibechana-68838	296	20	,	,	PUNCT
bibechana-68838	296	21	g.h	g.h	PROPN
bibechana-68838	296	22	.	.	PROPN
bibechana-68838	296	23	goodwin	goodwin	PROPN
bibechana-68838	296	24	,	,	PUNCT
bibechana-68838	296	25	p.e	p.e	PROPN
bibechana-68838	296	26	.	.	PROPN
bibechana-68838	296	27	neiman	neiman	PROPN
bibechana-68838	296	28	,	,	PUNCT
bibechana-68838	296	29	s.j	s.j	PROPN
bibechana-68838	296	30	.	.	PROPN
bibechana-68838	296	31	collins	collins	PROPN
bibechana-68838	296	32	,	,	PUNCT
bibechana-68838	296	33	and	and	CCONJ
bibechana-68838	296	34	v.v	v.v	PROPN
bibechana-68838	296	35	.	.	PROPN
bibechana-68838	296	36	lobanenkov	lobanenkov	PROPN
bibechana-68838	296	37	.	.	PUNCT
bibechana-68838	297	1	an	an	DET
bibechana-68838	297	2	exceptionally	exceptionally	ADV
bibechana-68838	297	3	conserved	conserved	ADJ
bibechana-68838	297	4	transcriptional	transcriptional	ADJ
bibechana-68838	297	5	repressor	repressor	NOUN
bibechana-68838	297	6	,	,	PUNCT
bibechana-68838	297	7	ctcf	ctcf	ADJ
bibechana-68838	297	8	,	,	PUNCT
bibechana-68838	297	9	employs	employ	VERB
bibechana-68838	297	10	different	different	ADJ
bibechana-68838	297	11	combinations	combination	NOUN
bibechana-68838	297	12	of	of	ADP
bibechana-68838	297	13	zinc	zinc	NOUN
bibechana-68838	297	14	fingers	finger	NOUN
bibechana-68838	297	15	to	to	PART
bibechana-68838	297	16	bind	bind	VERB
bibechana-68838	297	17	diverged	diverged	ADJ
bibechana-68838	297	18	promoter	promoter	NOUN
bibechana-68838	297	19	bidhya	bidhya	PROPN
bibechana-68838	297	20	thapa	thapa	PROPN
bibechana-68838	297	21	and	and	CCONJ
bibechana-68838	297	22	narayan	narayan	PROPN
bibechana-68838	297	23	prasad	prasad	PROPN
bibechana-68838	297	24	adhikari/	adhikari/	NUM
bibechana-68838	297	25	bibechana	bibechana	NOUN
bibechana-68838	297	26	21	21	NUM
bibechana-68838	297	27	(	(	PUNCT
bibechana-68838	297	28	2024	2024	NUM
bibechana-68838	297	29	)	)	PUNCT
bibechana-68838	297	30	290	290	NUM
bibechana-68838	297	31	-	-	SYM
bibechana-68838	297	32	299	299	NUM
bibechana-68838	297	33	299	299	NUM
bibechana-68838	297	34	sequences	sequence	NOUN
bibechana-68838	297	35	of	of	ADP
bibechana-68838	297	36	avian	avian	ADJ
bibechana-68838	297	37	and	and	CCONJ
bibechana-68838	297	38	mammalian	mammalian	ADJ
bibechana-68838	297	39	c	c	PROPN
bibechana-68838	297	40	-	-	PUNCT
bibechana-68838	297	41	myc	myc	NOUN
bibechana-68838	297	42	oncogenes	oncogene	NOUN
bibechana-68838	297	43	.	.	PUNCT
bibechana-68838	298	1	molecular	molecular	ADJ
bibechana-68838	298	2	and	and	CCONJ
bibechana-68838	298	3	cellular	cellular	ADJ
bibechana-68838	298	4	biology	biology	NOUN
bibechana-68838	298	5	,	,	PUNCT
bibechana-68838	298	6	16(6):2802–2813	16(6):2802–2813	NUM
bibechana-68838	298	7	,	,	PUNCT
bibechana-68838	298	8	1996	1996	NUM
bibechana-68838	298	9	.	.	PUNCT
bibechana-68838	299	1	[	[	X
bibechana-68838	299	2	27	27	NUM
bibechana-68838	299	3	]	]	PUNCT
bibechana-68838	299	4	the	the	DET
bibechana-68838	299	5	uniprot	uniprot	ADJ
bibechana-68838	299	6	consortium	consortium	NOUN
bibechana-68838	299	7	.	.	PUNCT
bibechana-68838	300	1	uniprot	uniprot	ADJ
bibechana-68838	300	2	:	:	PUNCT
bibechana-68838	300	3	the	the	DET
bibechana-68838	300	4	universal	universal	ADJ
bibechana-68838	300	5	protein	protein	NOUN
bibechana-68838	300	6	knowledgebase	knowledgebase	NOUN
bibechana-68838	300	7	in	in	ADP
bibechana-68838	300	8	2021	2021	NUM
bibechana-68838	300	9	.	.	PUNCT
bibechana-68838	301	1	nucleic	nucleic	ADJ
bibechana-68838	301	2	acids	acid	NOUN
bibechana-68838	301	3	research	research	NOUN
bibechana-68838	301	4	,	,	PUNCT
bibechana-68838	301	5	49(d1):d480	49(d1):d480	NUM
bibechana-68838	301	6	–	–	PUNCT
bibechana-68838	301	7	d489	d489	PROPN
bibechana-68838	301	8	,	,	PUNCT
bibechana-68838	301	9	2021	2021	NUM
bibechana-68838	301	10	.	.	PUNCT
bibechana-68838	302	1	[	[	X
bibechana-68838	302	2	28	28	NUM
bibechana-68838	302	3	]	]	X
bibechana-68838	302	4	milot	milot	NOUN
bibechana-68838	302	5	mirdita	mirdita	NOUN
bibechana-68838	302	6	,	,	PUNCT
bibechana-68838	302	7	martin	martin	PROPN
bibechana-68838	302	8	steinegger	steinegger	ADV
bibechana-68838	302	9	,	,	PUNCT
bibechana-68838	302	10	and	and	CCONJ
bibechana-68838	302	11	johannes	johanne	NOUN
bibechana-68838	302	12	söding	söding	NOUN
bibechana-68838	302	13	.	.	PUNCT
bibechana-68838	303	1	mmseqs2	mmseqs2	PROPN
bibechana-68838	303	2	desktop	desktop	NOUN
bibechana-68838	303	3	and	and	CCONJ
bibechana-68838	303	4	local	local	ADJ
bibechana-68838	303	5	web	web	NOUN
bibechana-68838	303	6	server	server	NOUN
bibechana-68838	303	7	app	app	NOUN
bibechana-68838	303	8	for	for	ADP
bibechana-68838	303	9	fast	fast	ADJ
bibechana-68838	303	10	,	,	PUNCT
bibechana-68838	303	11	interactive	interactive	ADJ
bibechana-68838	303	12	sequence	sequence	NOUN
bibechana-68838	303	13	searches	search	NOUN
bibechana-68838	303	14	.	.	PUNCT
bibechana-68838	304	1	bioinformatics	bioinformatic	NOUN
bibechana-68838	304	2	,	,	PUNCT
bibechana-68838	304	3	35(16):2856–2858	35(16):2856–2858	NUM
bibechana-68838	304	4	,	,	PUNCT
bibechana-68838	304	5	2019	2019	NUM
bibechana-68838	304	6	.	.	PUNCT
bibechana-68838	305	1	[	[	X
bibechana-68838	305	2	29	29	NUM
bibechana-68838	305	3	]	]	X
bibechana-68838	305	4	richard	richard	PROPN
bibechana-68838	305	5	evans	evans	PROPN
bibechana-68838	305	6	,	,	PUNCT
bibechana-68838	305	7	michael	michael	PROPN
bibechana-68838	305	8	o’neill	o’neill	PROPN
bibechana-68838	305	9	,	,	PUNCT
bibechana-68838	305	10	alexander	alexander	PROPN
bibechana-68838	305	11	pritzel	pritzel	PROPN
bibechana-68838	305	12	,	,	PUNCT
bibechana-68838	305	13	et	et	PROPN
bibechana-68838	305	14	al	al	PROPN
bibechana-68838	305	15	.	.	PUNCT
bibechana-68838	305	16	protein	protein	NOUN
bibechana-68838	305	17	complex	complex	ADJ
bibechana-68838	305	18	prediction	prediction	NOUN
bibechana-68838	305	19	with	with	ADP
bibechana-68838	305	20	alphafold	alphafold	ADJ
bibechana-68838	305	21	-	-	PUNCT
bibechana-68838	305	22	multimer	multimer	NOUN
bibechana-68838	305	23	.	.	PROPN
bibechana-68838	305	24	biorxiv	biorxiv	PROPN
bibechana-68838	305	25	,	,	PUNCT
bibechana-68838	305	26	page	page	NOUN
bibechana-68838	305	27	2021.10.04.463034	2021.10.04.463034	NOUN
bibechana-68838	305	28	,	,	PUNCT
bibechana-68838	305	29	2021	2021	NUM
bibechana-68838	305	30	.	.	PUNCT
bibechana-68838	306	1	[	[	X
bibechana-68838	306	2	30	30	NUM
bibechana-68838	306	3	]	]	X
bibechana-68838	306	4	milot	milot	NOUN
bibechana-68838	306	5	mirdita	mirdita	PROPN
bibechana-68838	306	6	,	,	PUNCT
bibechana-68838	306	7	konstantin	konstantin	PROPN
bibechana-68838	306	8	schütze	schütze	PROPN
bibechana-68838	306	9	,	,	PUNCT
bibechana-68838	306	10	yu	yu	PROPN
bibechana-68838	306	11	moriwaki	moriwaki	PROPN
bibechana-68838	306	12	,	,	PUNCT
bibechana-68838	306	13	et	et	PROPN
bibechana-68838	306	14	al	al	PROPN
bibechana-68838	306	15	.	.	PROPN
bibechana-68838	306	16	colabfold	colabfold	PROPN
bibechana-68838	306	17	:	:	PUNCT
bibechana-68838	306	18	making	make	VERB
bibechana-68838	306	19	protein	protein	NOUN
bibechana-68838	306	20	folding	fold	VERB
bibechana-68838	306	21	accessible	accessible	ADJ
bibechana-68838	306	22	to	to	ADP
bibechana-68838	306	23	all	all	PRON
bibechana-68838	306	24	.	.	PUNCT
bibechana-68838	307	1	nature	nature	NOUN
bibechana-68838	307	2	methods	method	NOUN
bibechana-68838	307	3	,	,	PUNCT
bibechana-68838	307	4	19(6):679	19(6):679	NUM
bibechana-68838	307	5	–	–	PUNCT
bibechana-68838	307	6	682	682	NUM
bibechana-68838	307	7	,	,	PUNCT
bibechana-68838	307	8	2022	2022	NUM
bibechana-68838	307	9	.	.	PUNCT
bibechana-68838	308	1	[	[	X
bibechana-68838	308	2	31	31	NUM
bibechana-68838	308	3	]	]	X
bibechana-68838	308	4	jooyoung	jooyoung	PROPN
bibechana-68838	308	5	lee	lee	PROPN
bibechana-68838	308	6	,	,	PUNCT
bibechana-68838	308	7	xiaolin	xiaolin	PROPN
bibechana-68838	308	8	cheng	cheng	PROPN
bibechana-68838	308	9	,	,	PUNCT
bibechana-68838	308	10	jason	jason	PROPN
bibechana-68838	308	11	m	m	PROPN
bibechana-68838	308	12	swails	swails	PROPN
bibechana-68838	308	13	,	,	PUNCT
bibechana-68838	308	14	et	et	PROPN
bibechana-68838	308	15	al	al	PROPN
bibechana-68838	308	16	.	.	PROPN
bibechana-68838	308	17	charmm	charmm	PROPN
bibechana-68838	308	18	-	-	PUNCT
bibechana-68838	308	19	gui	gui	NOUN
bibechana-68838	308	20	input	input	NOUN
bibechana-68838	308	21	generator	generator	NOUN
bibechana-68838	308	22	for	for	ADP
bibechana-68838	308	23	namd	namd	NOUN
bibechana-68838	308	24	,	,	PUNCT
bibechana-68838	308	25	gromacs	gromacs	PROPN
bibechana-68838	308	26	,	,	PUNCT
bibechana-68838	308	27	amber	amber	PROPN
bibechana-68838	308	28	,	,	PUNCT
bibechana-68838	308	29	openmm	openmm	PROPN
bibechana-68838	308	30	,	,	PUNCT
bibechana-68838	308	31	and	and	CCONJ
bibechana-68838	308	32	charmm	charmm	NOUN
bibechana-68838	308	33	/	/	SYM
bibechana-68838	308	34	openmm	openmm	NOUN
bibechana-68838	308	35	simulations	simulation	NOUN
bibechana-68838	308	36	using	use	VERB
bibechana-68838	308	37	the	the	DET
bibechana-68838	308	38	charmm36	charmm36	NOUN
bibechana-68838	308	39	additive	additive	ADJ
bibechana-68838	308	40	force	force	NOUN
bibechana-68838	308	41	field	field	NOUN
bibechana-68838	308	42	.	.	PUNCT
bibechana-68838	309	1	biophysical	biophysical	ADJ
bibechana-68838	309	2	journal	journal	NOUN
bibechana-68838	309	3	,	,	PUNCT
bibechana-68838	309	4	110(3):641a	110(3):641a	NUM
bibechana-68838	309	5	,	,	PUNCT
bibechana-68838	309	6	2016	2016	NUM
bibechana-68838	309	7	.	.	PUNCT
bibechana-68838	310	1	[	[	X
bibechana-68838	310	2	32	32	NUM
bibechana-68838	310	3	]	]	X
bibechana-68838	310	4	james	james	PROPN
bibechana-68838	310	5	c	c	PROPN
bibechana-68838	310	6	phillips	phillips	PROPN
bibechana-68838	310	7	,	,	PUNCT
bibechana-68838	310	8	rosemary	rosemary	ADJ
bibechana-68838	310	9	braun	braun	NOUN
bibechana-68838	310	10	,	,	PUNCT
bibechana-68838	310	11	wei	wei	PROPN
bibechana-68838	310	12	wang	wang	PROPN
bibechana-68838	310	13	,	,	PUNCT
bibechana-68838	310	14	et	et	PROPN
bibechana-68838	310	15	al	al	PROPN
bibechana-68838	310	16	.	.	PROPN
bibechana-68838	310	17	scalable	scalable	ADJ
bibechana-68838	310	18	molecular	molecular	ADJ
bibechana-68838	310	19	dynamics	dynamic	NOUN
bibechana-68838	310	20	with	with	ADP
bibechana-68838	310	21	namd	namd	ADJ
bibechana-68838	310	22	.	.	PROPN
bibechana-68838	310	23	journal	journal	PROPN
bibechana-68838	310	24	of	of	ADP
bibechana-68838	310	25	computational	computational	ADJ
bibechana-68838	310	26	chemistry	chemistry	NOUN
bibechana-68838	310	27	,	,	PUNCT
bibechana-68838	310	28	26(16):1781–1802	26(16):1781–1802	NUM
bibechana-68838	310	29	,	,	PUNCT
bibechana-68838	310	30	2005	2005	NUM
bibechana-68838	310	31	.	.	PUNCT
bibechana-68838	311	1	[	[	X
bibechana-68838	311	2	33	33	NUM
bibechana-68838	311	3	]	]	X
bibechana-68838	311	4	jing	jing	PROPN
bibechana-68838	311	5	huang	huang	PROPN
bibechana-68838	311	6	and	and	CCONJ
bibechana-68838	311	7	alexander	alexander	PROPN
bibechana-68838	311	8	d	d	PROPN
bibechana-68838	311	9	mackerell	mackerell	PROPN
bibechana-68838	311	10	.	.	PUNCT
bibechana-68838	312	1	charmm36	charmm36	VERB
bibechana-68838	312	2	all	all	ADV
bibechana-68838	312	3	-	-	PUNCT
bibechana-68838	312	4	atom	atom	NOUN
bibechana-68838	312	5	additive	additive	ADJ
bibechana-68838	312	6	protein	protein	NOUN
bibechana-68838	312	7	force	force	NOUN
bibechana-68838	312	8	field	field	NOUN
bibechana-68838	312	9	:	:	PUNCT
bibechana-68838	312	10	validation	validation	NOUN
bibechana-68838	312	11	based	base	VERB
bibechana-68838	312	12	on	on	ADP
bibechana-68838	312	13	comparison	comparison	NOUN
bibechana-68838	312	14	to	to	ADP
bibechana-68838	312	15	nmr	nmr	NOUN
bibechana-68838	312	16	data	datum	NOUN
bibechana-68838	312	17	.	.	PUNCT
bibechana-68838	313	1	journal	journal	PROPN
bibechana-68838	313	2	of	of	ADP
bibechana-68838	313	3	computational	computational	ADJ
bibechana-68838	313	4	chemistry	chemistry	NOUN
bibechana-68838	313	5	,	,	PUNCT
bibechana-68838	313	6	34(25):2135–2145	34(25):2135–2145	PROPN
bibechana-68838	313	7	,	,	PUNCT
bibechana-68838	313	8	2013	2013	NUM
bibechana-68838	313	9	.	.	PUNCT
bibechana-68838	314	1	[	[	X
bibechana-68838	314	2	34	34	NUM
bibechana-68838	314	3	]	]	X
bibechana-68838	314	4	rajendra	rajendra	PROPN
bibechana-68838	314	5	koirala	koirala	PROPN
bibechana-68838	314	6	,	,	PUNCT
bibechana-68838	314	7	bidhya	bidhya	PROPN
bibechana-68838	314	8	thapa	thapa	PROPN
bibechana-68838	314	9	,	,	PUNCT
bibechana-68838	314	10	shyam	shyam	PROPN
bibechana-68838	314	11	p	p	PROPN
bibechana-68838	314	12	khanal	khanal	NOUN
bibechana-68838	314	13	,	,	PUNCT
bibechana-68838	314	14	jhulan	jhulan	PROPN
bibechana-68838	314	15	powrel	powrel	NOUN
bibechana-68838	314	16	,	,	PUNCT
bibechana-68838	314	17	rajendra	rajendra	PROPN
bibechana-68838	314	18	p	p	PROPN
bibechana-68838	314	19	adhikari	adhikari	PROPN
bibechana-68838	314	20	,	,	PUNCT
bibechana-68838	314	21	and	and	CCONJ
bibechana-68838	314	22	narayan	narayan	NOUN
bibechana-68838	314	23	p	p	ADJ
bibechana-68838	314	24	adhikari	adhikari	PROPN
bibechana-68838	314	25	.	.	PUNCT
bibechana-68838	315	1	binding	bind	VERB
bibechana-68838	315	2	of	of	ADP
bibechana-68838	315	3	sars	sars	PROPN
bibechana-68838	315	4	-	-	PUNCT
bibechana-68838	315	5	cov2	cov2	PROPN
bibechana-68838	315	6	/	/	SYM
bibechana-68838	315	7	sars	sars	PROPN
bibechana-68838	315	8	-	-	PUNCT
bibechana-68838	315	9	cov	cov	NOUN
bibechana-68838	315	10	spike	spike	ADJ
bibechana-68838	315	11	protein	protein	NOUN
bibechana-68838	315	12	with	with	ADP
bibechana-68838	315	13	human	human	ADJ
bibechana-68838	315	14	ace2	ace2	NOUN
bibechana-68838	315	15	receptor	receptor	NOUN
bibechana-68838	315	16	.	.	PUNCT
bibechana-68838	316	1	journal	journal	PROPN
bibechana-68838	316	2	of	of	ADP
bibechana-68838	316	3	physics	physics	PROPN
bibechana-68838	316	4	communications	communication	NOUN
bibechana-68838	316	5	,	,	PUNCT
bibechana-68838	316	6	5(3):035010	5(3):035010	NUM
bibechana-68838	316	7	,	,	PUNCT
bibechana-68838	316	8	2021	2021	NUM
bibechana-68838	316	9	.	.	PUNCT
bibechana-68838	317	1	[	[	X
bibechana-68838	317	2	35	35	NUM
bibechana-68838	317	3	]	]	SYM
bibechana-68838	317	4	bidhya	bidhya	PROPN
bibechana-68838	317	5	thapa	thapa	PROPN
bibechana-68838	317	6	and	and	CCONJ
bibechana-68838	317	7	narayan	narayan	NOUN
bibechana-68838	317	8	p	p	ADJ
bibechana-68838	317	9	adhikari	adhikari	PROPN
bibechana-68838	317	10	.	.	PUNCT
bibechana-68838	318	1	molecular	molecular	ADJ
bibechana-68838	318	2	interactions	interaction	NOUN
bibechana-68838	318	3	of	of	ADP
bibechana-68838	318	4	zinc	zinc	NOUN
bibechana-68838	318	5	finger	finger	NOUN
bibechana-68838	318	6	protein	protein	NOUN
bibechana-68838	318	7	kaiso	kaiso	NOUN
bibechana-68838	318	8	with	with	ADP
bibechana-68838	318	9	hemimethylated	hemimethylate	VERB
bibechana-68838	318	10	dna	dna	PROPN
bibechana-68838	318	11	.	.	PUNCT
bibechana-68838	319	1	journal	journal	PROPN
bibechana-68838	319	2	of	of	ADP
bibechana-68838	319	3	nepal	nepal	PROPN
bibechana-68838	319	4	physical	physical	ADJ
bibechana-68838	319	5	society	society	NOUN
bibechana-68838	319	6	,	,	PUNCT
bibechana-68838	319	7	9(1):1–10	9(1):1–10	NOUN
bibechana-68838	319	8	,	,	PUNCT
bibechana-68838	319	9	2023	2023	NUM
bibechana-68838	319	10	.	.	PUNCT
bibechana-68838	320	1	[	[	X
bibechana-68838	320	2	36	36	NUM
bibechana-68838	320	3	]	]	X
bibechana-68838	320	4	bidhya	bidhya	PROPN
bibechana-68838	320	5	thapa	thapa	PROPN
bibechana-68838	320	6	,	,	PUNCT
bibechana-68838	320	7	narayan	narayan	PROPN
bibechana-68838	320	8	p	p	X
bibechana-68838	320	9	adhikari	adhikari	PROPN
bibechana-68838	320	10	,	,	PUNCT
bibechana-68838	320	11	purushottam	purushottam	PROPN
bibechana-68838	320	12	b	b	PROPN
bibechana-68838	320	13	tiwari	tiwari	PROPN
bibechana-68838	320	14	,	,	PUNCT
bibechana-68838	320	15	and	and	CCONJ
bibechana-68838	320	16	prem	prem	ADJ
bibechana-68838	320	17	p	p	NOUN
bibechana-68838	320	18	chapagain	chapagain	NOUN
bibechana-68838	320	19	.	.	PUNCT
bibechana-68838	321	1	a	a	DET
bibechana-68838	321	2	5flanking	5flanking	PROPN
bibechana-68838	321	3	c	c	NOUN
bibechana-68838	321	4	/	/	SYM
bibechana-68838	321	5	g	g	NOUN
bibechana-68838	321	6	pair	pair	NOUN
bibechana-68838	321	7	at	at	ADP
bibechana-68838	321	8	the	the	DET
bibechana-68838	321	9	core	core	NOUN
bibechana-68838	321	10	region	region	NOUN
bibechana-68838	321	11	enhances	enhance	VERB
bibechana-68838	321	12	the	the	DET
bibechana-68838	321	13	recognition	recognition	NOUN
bibechana-68838	321	14	and	and	CCONJ
bibechana-68838	321	15	binding	binding	NOUN
bibechana-68838	321	16	of	of	ADP
bibechana-68838	321	17	kaiso	kaiso	NOUN
bibechana-68838	321	18	to	to	ADP
bibechana-68838	321	19	methylated	methylate	VERB
bibechana-68838	321	20	dna	dna	PROPN
bibechana-68838	321	21	.	.	PUNCT
bibechana-68838	322	1	journal	journal	PROPN
bibechana-68838	322	2	of	of	ADP
bibechana-68838	322	3	chemical	chemical	ADJ
bibechana-68838	322	4	information	information	NOUN
bibechana-68838	322	5	and	and	CCONJ
bibechana-68838	322	6	modeling	modeling	NOUN
bibechana-68838	322	7	,	,	PUNCT
bibechana-68838	322	8	63(7):2095–2103	63(7):2095–2103	NUM
bibechana-68838	322	9	,	,	PUNCT
bibechana-68838	322	10	2022	2022	NUM
bibechana-68838	322	11	.	.	PUNCT
bibechana-68838	323	1	[	[	X
bibechana-68838	323	2	37	37	NUM
bibechana-68838	323	3	]	]	PUNCT
bibechana-68838	323	4	ulrich	ulrich	PROPN
bibechana-68838	323	5	essmann	essmann	PROPN
bibechana-68838	323	6	,	,	PUNCT
bibechana-68838	323	7	lalith	lalith	ADP
bibechana-68838	323	8	perera	perera	PROPN
bibechana-68838	323	9	,	,	PUNCT
bibechana-68838	323	10	max	max	PROPN
bibechana-68838	323	11	l	l	PROPN
bibechana-68838	323	12	berkowitz	berkowitz	PROPN
bibechana-68838	323	13	,	,	PUNCT
bibechana-68838	323	14	et	et	PROPN
bibechana-68838	323	15	al	al	PROPN
bibechana-68838	323	16	.	.	PUNCT
bibechana-68838	324	1	a	a	DET
bibechana-68838	324	2	smooth	smooth	ADJ
bibechana-68838	324	3	particle	particle	NOUN
bibechana-68838	324	4	mesh	mesh	NOUN
bibechana-68838	324	5	ewald	ewald	PROPN
bibechana-68838	324	6	method	method	NOUN
bibechana-68838	324	7	.	.	PUNCT
bibechana-68838	325	1	the	the	DET
bibechana-68838	325	2	journal	journal	PROPN
bibechana-68838	325	3	of	of	ADP
bibechana-68838	325	4	chemical	chemical	PROPN
bibechana-68838	325	5	physics	physics	PROPN
bibechana-68838	325	6	,	,	PUNCT
bibechana-68838	325	7	103(19):8577–8593	103(19):8577–8593	NUM
bibechana-68838	325	8	,	,	PUNCT
bibechana-68838	325	9	1995	1995	NUM
bibechana-68838	325	10	.	.	PUNCT
bibechana-68838	326	1	[	[	X
bibechana-68838	326	2	38	38	NUM
bibechana-68838	326	3	]	]	PUNCT
bibechana-68838	326	4	william	william	PROPN
bibechana-68838	326	5	humphrey	humphrey	PROPN
bibechana-68838	326	6	,	,	PUNCT
bibechana-68838	326	7	andrew	andrew	PROPN
bibechana-68838	326	8	dalke	dalke	PROPN
bibechana-68838	326	9	,	,	PUNCT
bibechana-68838	326	10	and	and	CCONJ
bibechana-68838	326	11	klaus	klaus	PROPN
bibechana-68838	326	12	schulten	schulten	PROPN
bibechana-68838	326	13	.	.	PUNCT
bibechana-68838	327	1	vmd	vmd	PROPN
bibechana-68838	327	2	:	:	PUNCT
bibechana-68838	327	3	visual	visual	ADJ
bibechana-68838	327	4	molecular	molecular	ADJ
bibechana-68838	327	5	dynamics	dynamic	NOUN
bibechana-68838	327	6	.	.	PUNCT
bibechana-68838	328	1	journal	journal	NOUN
bibechana-68838	328	2	of	of	ADP
bibechana-68838	328	3	molecular	molecular	ADJ
bibechana-68838	328	4	graphics	graphic	NOUN
bibechana-68838	328	5	,	,	PUNCT
bibechana-68838	328	6	14(1):33–38	14(1):33–38	NUM
bibechana-68838	328	7	,	,	PUNCT
bibechana-68838	328	8	1996	1996	NUM
bibechana-68838	328	9	.	.	PUNCT
bibechana-68838	329	1	[	[	X
bibechana-68838	329	2	39	39	NUM
bibechana-68838	329	3	]	]	PUNCT
bibechana-68838	329	4	xue	xue	PROPN
bibechana-68838	329	5	zou	zou	PROPN
bibechana-68838	329	6	,	,	PUNCT
bibechana-68838	329	7	wei	wei	PROPN
bibechana-68838	329	8	ma	ma	PROPN
bibechana-68838	329	9	,	,	PUNCT
bibechana-68838	329	10	ilia	ilia	PROPN
bibechana-68838	329	11	a	a	DET
bibechana-68838	329	12	solov’yov	solov’yov	NOUN
bibechana-68838	329	13	,	,	PUNCT
bibechana-68838	329	14	et	et	PROPN
bibechana-68838	329	15	al	al	PROPN
bibechana-68838	329	16	.	.	PUNCT
bibechana-68838	329	17	recognition	recognition	NOUN
bibechana-68838	329	18	of	of	ADP
bibechana-68838	329	19	methylated	methylate	VERB
bibechana-68838	329	20	dna	dna	NOUN
bibechana-68838	329	21	through	through	ADP
bibechana-68838	329	22	methyl	methyl	NOUN
bibechana-68838	329	23	-	-	PUNCT
bibechana-68838	329	24	cpg	cpg	NOUN
bibechana-68838	329	25	binding	bind	VERB
bibechana-68838	329	26	domain	domain	NOUN
bibechana-68838	329	27	proteins	protein	NOUN
bibechana-68838	329	28	.	.	PUNCT
bibechana-68838	330	1	nucleic	nucleic	ADJ
bibechana-68838	330	2	acids	acid	NOUN
bibechana-68838	330	3	research	research	NOUN
bibechana-68838	330	4	,	,	PUNCT
bibechana-68838	330	5	40(6):2747–2758	40(6):2747–2758	NUM
bibechana-68838	330	6	,	,	PUNCT
bibechana-68838	330	7	2012	2012	NUM
bibechana-68838	330	8	.	.	PUNCT
bibechana-68838	331	1	[	[	X
bibechana-68838	331	2	40	40	NUM
bibechana-68838	331	3	]	]	PUNCT
bibechana-68838	331	4	barbara	barbara	PROPN
bibechana-68838	331	5	vallone	vallone	PROPN
bibechana-68838	331	6	,	,	PUNCT
bibechana-68838	331	7	adriana	adriana	PROPN
bibechana-68838	331	8	e	e	PROPN
bibechana-68838	331	9	miele	miele	PROPN
bibechana-68838	331	10	,	,	PUNCT
bibechana-68838	331	11	pier	pier	PROPN
bibechana-68838	331	12	carlo	carlo	PROPN
bibechana-68838	331	13	vecchini	vecchini	PROPN
bibechana-68838	331	14	,	,	PUNCT
bibechana-68838	331	15	et	et	PROPN
bibechana-68838	331	16	al	al	PROPN
bibechana-68838	331	17	.	.	PROPN
bibechana-68838	331	18	free	free	ADJ
bibechana-68838	331	19	energy	energy	NOUN
bibechana-68838	331	20	of	of	ADP
bibechana-68838	331	21	burying	bury	VERB
bibechana-68838	331	22	hydrophobic	hydrophobic	NOUN
bibechana-68838	331	23	residues	residue	NOUN
bibechana-68838	331	24	in	in	ADP
bibechana-68838	331	25	the	the	DET
bibechana-68838	331	26	interface	interface	NOUN
bibechana-68838	331	27	between	between	ADP
bibechana-68838	331	28	protein	protein	NOUN
bibechana-68838	331	29	subunits	subunit	NOUN
bibechana-68838	331	30	.	.	PUNCT
bibechana-68838	332	1	proceedings	proceeding	NOUN
bibechana-68838	332	2	of	of	ADP
bibechana-68838	332	3	the	the	DET
bibechana-68838	332	4	national	national	PROPN
bibechana-68838	332	5	academy	academy	PROPN
bibechana-68838	332	6	of	of	ADP
bibechana-68838	332	7	sciences	sciences	PROPN
bibechana-68838	332	8	,	,	PUNCT
bibechana-68838	332	9	95(11):6103–6107	95(11):6103–6107	NUM
bibechana-68838	332	10	,	,	PUNCT
bibechana-68838	332	11	1998	1998	NUM
bibechana-68838	332	12	.	.	PUNCT
bibechana-68838	333	1	[	[	X
bibechana-68838	333	2	41	41	NUM
bibechana-68838	333	3	]	]	PUNCT
bibechana-68838	333	4	tingjun	tingjun	PROPN
bibechana-68838	333	5	hou	hou	PROPN
bibechana-68838	333	6	,	,	PUNCT
bibechana-68838	333	7	junmei	junmei	PROPN
bibechana-68838	333	8	wang	wang	PROPN
bibechana-68838	333	9	,	,	PUNCT
bibechana-68838	333	10	youyong	youyong	PROPN
bibechana-68838	333	11	li	li	PROPN
bibechana-68838	333	12	,	,	PUNCT
bibechana-68838	333	13	et	et	PROPN
bibechana-68838	333	14	al	al	PROPN
bibechana-68838	333	15	.	.	PUNCT
bibechana-68838	334	1	assessing	assess	VERB
bibechana-68838	334	2	the	the	DET
bibechana-68838	334	3	performance	performance	NOUN
bibechana-68838	334	4	of	of	ADP
bibechana-68838	334	5	the	the	DET
bibechana-68838	334	6	mm	mm	NOUN
bibechana-68838	334	7	/	/	SYM
bibechana-68838	334	8	pbsa	pbsa	NOUN
bibechana-68838	334	9	and	and	CCONJ
bibechana-68838	334	10	mm	mm	NOUN
bibechana-68838	334	11	/	/	SYM
bibechana-68838	334	12	gbsa	gbsa	ADJ
bibechana-68838	334	13	methods	method	NOUN
bibechana-68838	334	14	.	.	PUNCT
bibechana-68838	335	1	1	1	X
bibechana-68838	335	2	.	.	PUNCT
bibechana-68838	336	1	the	the	DET
bibechana-68838	336	2	accuracy	accuracy	NOUN
bibechana-68838	336	3	of	of	ADP
bibechana-68838	336	4	binding	bind	VERB
bibechana-68838	336	5	free	free	ADJ
bibechana-68838	336	6	energy	energy	NOUN
bibechana-68838	336	7	calculations	calculation	NOUN
bibechana-68838	336	8	based	base	VERB
bibechana-68838	336	9	on	on	ADP
bibechana-68838	336	10	molecular	molecular	ADJ
bibechana-68838	336	11	dynamics	dynamic	NOUN
bibechana-68838	336	12	simulations	simulation	NOUN
bibechana-68838	336	13	.	.	PUNCT
bibechana-68838	337	1	journal	journal	NOUN
bibechana-68838	337	2	of	of	ADP
bibechana-68838	337	3	chemical	chemical	ADJ
bibechana-68838	337	4	information	information	NOUN
bibechana-68838	337	5	and	and	CCONJ
bibechana-68838	337	6	modeling	modeling	NOUN
bibechana-68838	337	7	,	,	PUNCT
bibechana-68838	337	8	51(1):69	51(1):69	NOUN
bibechana-68838	337	9	–	–	PUNCT
bibechana-68838	337	10	82	82	NUM
bibechana-68838	337	11	,	,	PUNCT
bibechana-68838	337	12	2011	2011	NUM
bibechana-68838	337	13	.	.	PUNCT
bibechana-68838	338	1	[	[	X
bibechana-68838	338	2	42	42	NUM
bibechana-68838	338	3	]	]	X
bibechana-68838	338	4	hao	hao	PROPN
bibechana-68838	338	5	sun	sun	PROPN
bibechana-68838	338	6	,	,	PUNCT
bibechana-68838	338	7	yu	yu	PROPN
bibechana-68838	338	8	li	li	PROPN
bibechana-68838	338	9	,	,	PUNCT
bibechana-68838	338	10	shengnan	shengnan	PROPN
bibechana-68838	338	11	tian	tian	PROPN
bibechana-68838	338	12	,	,	PUNCT
bibechana-68838	338	13	et	et	PROPN
bibechana-68838	338	14	al	al	PROPN
bibechana-68838	338	15	.	.	PUNCT
bibechana-68838	339	1	assessing	assess	VERB
bibechana-68838	339	2	the	the	DET
bibechana-68838	339	3	performance	performance	NOUN
bibechana-68838	339	4	of	of	ADP
bibechana-68838	339	5	mm	mm	PROPN
bibechana-68838	339	6	/	/	SYM
bibechana-68838	339	7	pbsa	pbsa	NOUN
bibechana-68838	339	8	and	and	CCONJ
bibechana-68838	339	9	mm	mm	NOUN
bibechana-68838	339	10	/	/	SYM
bibechana-68838	339	11	gbsa	gbsa	ADJ
bibechana-68838	339	12	methods	method	NOUN
bibechana-68838	339	13	.	.	PUNCT
bibechana-68838	340	1	4	4	X
bibechana-68838	340	2	.	.	X
bibechana-68838	340	3	accuracies	accuracy	NOUN
bibechana-68838	340	4	of	of	ADP
bibechana-68838	340	5	mm	mm	PROPN
bibechana-68838	340	6	/	/	SYM
bibechana-68838	340	7	pbsa	pbsa	NOUN
bibechana-68838	340	8	and	and	CCONJ
bibechana-68838	340	9	mm	mm	PROPN
bibechana-68838	340	10	/	/	SYM
bibechana-68838	340	11	gbsa	gbsa	ADJ
bibechana-68838	340	12	methodologies	methodology	NOUN
bibechana-68838	340	13	evaluated	evaluate	VERB
bibechana-68838	340	14	by	by	ADP
bibechana-68838	340	15	various	various	ADJ
bibechana-68838	340	16	simulation	simulation	NOUN
bibechana-68838	340	17	protocols	protocol	NOUN
bibechana-68838	340	18	using	use	VERB
bibechana-68838	340	19	pdbbind	pdbbind	PROPN
bibechana-68838	340	20	data	datum	NOUN
bibechana-68838	340	21	set	set	VERB
bibechana-68838	340	22	.	.	PUNCT
bibechana-68838	341	1	physical	physical	ADJ
bibechana-68838	341	2	chemistry	chemistry	NOUN
bibechana-68838	341	3	chemical	chemical	PROPN
bibechana-68838	341	4	physics	physics	PROPN
bibechana-68838	341	5	,	,	PUNCT
bibechana-68838	341	6	16(31):16719–16729	16(31):16719–16729	NUM
bibechana-68838	341	7	,	,	PUNCT
bibechana-68838	341	8	2014	2014	NUM
bibechana-68838	341	9	.	.	PUNCT
bibechana-68838	342	1	[	[	X
bibechana-68838	342	2	43	43	NUM
bibechana-68838	342	3	]	]	X
bibechana-68838	342	4	e	e	PROPN
bibechana-68838	342	5	wang	wang	PROPN
bibechana-68838	342	6	,	,	PUNCT
bibechana-68838	342	7	hao	hao	PROPN
bibechana-68838	342	8	sun	sun	PROPN
bibechana-68838	342	9	,	,	PUNCT
bibechana-68838	342	10	j	j	PROPN
bibechana-68838	342	11	wang	wang	PROPN
bibechana-68838	342	12	,	,	PUNCT
bibechana-68838	342	13	et	et	PROPN
bibechana-68838	342	14	al	al	PROPN
bibechana-68838	342	15	.	.	PROPN
bibechana-68838	342	16	end	end	NOUN
bibechana-68838	342	17	-	-	PUNCT
bibechana-68838	342	18	point	point	NOUN
bibechana-68838	342	19	binding	binding	ADJ
bibechana-68838	342	20	free	free	ADJ
bibechana-68838	342	21	energy	energy	NOUN
bibechana-68838	342	22	calculation	calculation	NOUN
bibechana-68838	342	23	with	with	ADP
bibechana-68838	342	24	mm	mm	PROPN
bibechana-68838	342	25	/	/	SYM
bibechana-68838	342	26	pbsa	pbsa	NOUN
bibechana-68838	342	27	and	and	CCONJ
bibechana-68838	342	28	mm	mm	NOUN
bibechana-68838	342	29	/	/	SYM
bibechana-68838	342	30	gbsa	gbsa	PROPN
bibechana-68838	342	31	:	:	PUNCT
bibechana-68838	342	32	strategies	strategy	NOUN
bibechana-68838	342	33	and	and	CCONJ
bibechana-68838	342	34	applications	application	NOUN
bibechana-68838	342	35	in	in	ADP
bibechana-68838	342	36	drug	drug	NOUN
bibechana-68838	342	37	design	design	NOUN
bibechana-68838	342	38	.	.	PUNCT
bibechana-68838	343	1	chemical	chemical	NOUN
bibechana-68838	343	2	reviews	review	NOUN
bibechana-68838	343	3	,	,	PUNCT
bibechana-68838	343	4	119(16):9478	119(16):9478	NUM
bibechana-68838	343	5	–	–	PUNCT
bibechana-68838	343	6	9508	9508	NUM
bibechana-68838	343	7	,	,	PUNCT
bibechana-68838	343	8	2019	2019	NUM
bibechana-68838	343	9	.	.	PUNCT
bibechana-68838	344	1	[	[	X
bibechana-68838	344	2	44	44	NUM
bibechana-68838	344	3	]	]	X
bibechana-68838	344	4	tiziano	tiziano	PROPN
bibechana-68838	344	5	tuccinardi	tuccinardi	PROPN
bibechana-68838	344	6	.	.	PUNCT
bibechana-68838	345	1	what	what	PRON
bibechana-68838	345	2	is	be	AUX
bibechana-68838	345	3	the	the	DET
bibechana-68838	345	4	current	current	ADJ
bibechana-68838	345	5	value	value	NOUN
bibechana-68838	345	6	of	of	ADP
bibechana-68838	345	7	mm	mm	PROPN
bibechana-68838	345	8	/	/	SYM
bibechana-68838	345	9	pbsa	pbsa	NOUN
bibechana-68838	345	10	and	and	CCONJ
bibechana-68838	345	11	mm	mm	NOUN
bibechana-68838	345	12	/	/	SYM
bibechana-68838	345	13	gbsa	gbsa	ADJ
bibechana-68838	345	14	methods	method	NOUN
bibechana-68838	345	15	in	in	ADP
bibechana-68838	345	16	drug	drug	NOUN
bibechana-68838	345	17	discovery	discovery	NOUN
bibechana-68838	345	18	?	?	PUNCT
bibechana-68838	346	1	expert	expert	ADJ
bibechana-68838	346	2	opinion	opinion	NOUN
bibechana-68838	346	3	on	on	ADP
bibechana-68838	346	4	drug	drug	NOUN
bibechana-68838	346	5	discovery	discovery	NOUN
bibechana-68838	346	6	,	,	PUNCT
bibechana-68838	346	7	16(11):1233–1237	16(11):1233–1237	NUM
bibechana-68838	346	8	,	,	PUNCT
bibechana-68838	346	9	2021	2021	NUM
bibechana-68838	346	10	.	.	PUNCT
bibechana-68838	347	1	[	[	X
bibechana-68838	347	2	45	45	NUM
bibechana-68838	347	3	]	]	PUNCT
bibechana-68838	347	4	chethan	chethan	PROPN
bibechana-68838	347	5	mulakala	mulakala	PROPN
bibechana-68838	347	6	and	and	CCONJ
bibechana-68838	347	7	vellarkad	vellarkad	VERB
bibechana-68838	347	8	n	n	ADV
bibechana-68838	347	9	viswanadhan	viswanadhan	ADV
bibechana-68838	347	10	.	.	PUNCT
bibechana-68838	348	1	could	could	AUX
bibechana-68838	348	2	mm	mm	NOUN
bibechana-68838	348	3	-	-	PUNCT
bibechana-68838	348	4	gbsa	gbsa	NOUN
bibechana-68838	348	5	be	be	VERB
bibechana-68838	348	6	accurate	accurate	ADJ
bibechana-68838	348	7	enough	enough	ADV
bibechana-68838	348	8	for	for	ADP
bibechana-68838	348	9	calculation	calculation	NOUN
bibechana-68838	348	10	of	of	ADP
bibechana-68838	348	11	absolute	absolute	ADJ
bibechana-68838	348	12	protein	protein	NOUN
bibechana-68838	348	13	/	/	SYM
bibechana-68838	348	14	ligand	ligand	NOUN
bibechana-68838	348	15	binding	bind	VERB
bibechana-68838	348	16	free	free	ADJ
bibechana-68838	348	17	energies	energy	NOUN
bibechana-68838	348	18	?	?	PUNCT
bibechana-68838	349	1	journal	journal	NOUN
bibechana-68838	349	2	of	of	ADP
bibechana-68838	349	3	molecular	molecular	ADJ
bibechana-68838	349	4	graphics	graphic	NOUN
bibechana-68838	349	5	and	and	CCONJ
bibechana-68838	349	6	modelling	modelling	NOUN
bibechana-68838	349	7	,	,	PUNCT
bibechana-68838	349	8	46:41–51	46:41–51	PROPN
bibechana-68838	349	9	,	,	PUNCT
bibechana-68838	349	10	2013	2013	NUM
bibechana-68838	349	11	.	.	PUNCT
bibechana-68838	350	1	[	[	X
bibechana-68838	350	2	46	46	NUM
bibechana-68838	350	3	]	]	X
bibechana-68838	350	4	lokendra	lokendra	PROPN
bibechana-68838	350	5	s	s	PROPN
bibechana-68838	350	6	dhami	dhami	NOUN
bibechana-68838	350	7	,	,	PUNCT
bibechana-68838	350	8	prabin	prabin	NOUN
bibechana-68838	350	9	dahal	dahal	PROPN
bibechana-68838	350	10	,	,	PUNCT
bibechana-68838	350	11	bidhya	bidhya	PROPN
bibechana-68838	350	12	thapa	thapa	PROPN
bibechana-68838	350	13	,	,	PUNCT
bibechana-68838	350	14	narayan	narayan	PROPN
bibechana-68838	350	15	gautam	gautam	PROPN
bibechana-68838	350	16	,	,	PUNCT
bibechana-68838	350	17	nurapati	nurapati	PROPN
bibechana-68838	350	18	pantha	pantha	NOUN
bibechana-68838	350	19	,	,	PUNCT
bibechana-68838	350	20	rameshwar	rameshwar	ADJ
bibechana-68838	350	21	adhikari	adhikari	PROPN
bibechana-68838	350	22	,	,	PUNCT
bibechana-68838	350	23	and	and	CCONJ
bibechana-68838	350	24	narayan	narayan	NOUN
bibechana-68838	350	25	p	p	ADJ
bibechana-68838	350	26	adhikari	adhikari	PROPN
bibechana-68838	350	27	.	.	PUNCT
bibechana-68838	351	1	insights	insight	NOUN
bibechana-68838	351	2	from	from	ADP
bibechana-68838	351	3	in	in	ADP
bibechana-68838	351	4	silico	silico	NOUN
bibechana-68838	351	5	study	study	NOUN
bibechana-68838	351	6	of	of	ADP
bibechana-68838	351	7	receptor	receptor	NOUN
bibechana-68838	351	8	energetics	energetic	NOUN
bibechana-68838	351	9	of	of	ADP
bibechana-68838	351	10	sars	sar	NOUN
bibechana-68838	351	11	-	-	PUNCT
bibechana-68838	351	12	cov-2	cov-2	NOUN
bibechana-68838	351	13	variants	variant	NOUN
bibechana-68838	351	14	.	.	PUNCT
bibechana-68838	352	1	physical	physical	ADJ
bibechana-68838	352	2	chemistry	chemistry	NOUN
bibechana-68838	352	3	chemical	chemical	PROPN
bibechana-68838	352	4	physics	physics	PROPN
bibechana-68838	352	5	,	,	PUNCT
bibechana-68838	352	6	2024	2024	NUM
bibechana-68838	352	7	.	.	PUNCT
bibechana-68838	353	1	[	[	X
bibechana-68838	353	2	47	47	NUM
bibechana-68838	353	3	]	]	PUNCT
bibechana-68838	353	4	bidhya	bidhya	PROPN
bibechana-68838	353	5	thapa	thapa	PROPN
bibechana-68838	353	6	and	and	CCONJ
bibechana-68838	353	7	n	n	PRON
bibechana-68838	353	8	p	p	NOUN
bibechana-68838	353	9	adhikari	adhikari	PROPN
bibechana-68838	353	10	.	.	PUNCT
bibechana-68838	354	1	investigating	investigate	VERB
bibechana-68838	354	2	molecular	molecular	ADJ
bibechana-68838	354	3	interactions	interaction	NOUN
bibechana-68838	354	4	between	between	ADP
bibechana-68838	354	5	kaiso	kaiso	NOUN
bibechana-68838	354	6	and	and	CCONJ
bibechana-68838	354	7	nuclear	nuclear	ADJ
bibechana-68838	354	8	co	co	NOUN
bibechana-68838	354	9	-	-	NOUN
bibechana-68838	354	10	repressor	repressor	NOUN
bibechana-68838	354	11	using	use	VERB
bibechana-68838	354	12	molecular	molecular	ADJ
bibechana-68838	354	13	simulations	simulation	NOUN
bibechana-68838	354	14	.	.	PUNCT
bibechana-68838	355	1	aip	aip	PROPN
bibechana-68838	355	2	advances	advance	NOUN
bibechana-68838	355	3	,	,	PUNCT
bibechana-68838	355	4	14(6	14(6	NOUN
bibechana-68838	355	5	)	)	PUNCT
bibechana-68838	355	6	,	,	PUNCT
bibechana-68838	355	7	2024	2024	NUM
bibechana-68838	355	8	.	.	PUNCT
bibechana-68838	356	1	introduction	introduction	NOUN
bibechana-68838	356	2	materials	material	NOUN
bibechana-68838	356	3	and	and	CCONJ
bibechana-68838	356	4	methods	method	NOUN
bibechana-68838	356	5	protein	protein	NOUN
bibechana-68838	356	6	structures	structure	NOUN
bibechana-68838	356	7	and	and	CCONJ
bibechana-68838	356	8	molecular	molecular	ADJ
bibechana-68838	356	9	modeling	modeling	NOUN
bibechana-68838	356	10	system	system	NOUN
bibechana-68838	356	11	setup	setup	NOUN
bibechana-68838	356	12	and	and	CCONJ
bibechana-68838	356	13	molecular	molecular	ADJ
bibechana-68838	356	14	dynamics	dynamic	NOUN
bibechana-68838	356	15	simulations	simulation	NOUN
bibechana-68838	356	16	system	system	NOUN
bibechana-68838	356	17	setup	setup	NOUN
bibechana-68838	356	18	and	and	CCONJ
bibechana-68838	356	19	molecular	molecular	ADJ
bibechana-68838	356	20	dynamics	dynamic	NOUN
bibechana-68838	356	21	simulations	simulation	NOUN
bibechana-68838	356	22	results	result	NOUN
bibechana-68838	356	23	and	and	CCONJ
bibechana-68838	356	24	discussion	discussion	NOUN
bibechana-68838	356	25	modeling	modeling	NOUN
bibechana-68838	356	26	of	of	ADP
bibechana-68838	356	27	the	the	DET
bibechana-68838	356	28	kaiso	kaiso	NOUN
bibechana-68838	356	29	-	-	PUNCT
bibechana-68838	356	30	ctcf	ctcf	NOUN
bibechana-68838	356	31	complex	complex	ADJ
bibechana-68838	356	32	structural	structural	ADJ
bibechana-68838	356	33	stability	stability	NOUN
bibechana-68838	356	34	of	of	ADP
bibechana-68838	356	35	the	the	DET
bibechana-68838	356	36	complex	complex	ADJ
bibechana-68838	356	37	major	major	ADJ
bibechana-68838	356	38	interactions	interaction	NOUN
bibechana-68838	356	39	in	in	ADP
bibechana-68838	356	40	the	the	DET
bibechana-68838	356	41	kaiso	kaiso	NOUN
bibechana-68838	356	42	-	-	PUNCT
bibechana-68838	356	43	ctcf	ctcf	NOUN
bibechana-68838	356	44	complex	complex	ADJ
bibechana-68838	356	45	binding	binding	ADJ
bibechana-68838	356	46	free	free	ADJ
bibechana-68838	356	47	energy	energy	NOUN
bibechana-68838	356	48	of	of	ADP
bibechana-68838	356	49	the	the	DET
bibechana-68838	356	50	complex	complex	ADJ
bibechana-68838	356	51	conclusion	conclusion	NOUN