id	sid	tid	token	lemma	pos
bibechana-74254	1	1	bibechana	bibechana	PROPN
bibechana-74254	1	2	vol	vol	NOUN
bibechana-74254	1	3	.	.	PROPN
bibechana-74254	2	1	22	22	NUM
bibechana-74254	2	2	,	,	PUNCT
bibechana-74254	2	3	no	no	INTJ
bibechana-74254	2	4	.	.	NOUN
bibechana-74254	2	5	2	2	NUM
bibechana-74254	2	6	,	,	PUNCT
bibechana-74254	2	7	august	august	PROPN
bibechana-74254	2	8	2025	2025	NUM
bibechana-74254	2	9	,	,	PUNCT
bibechana-74254	2	10	108	108	NUM
bibechana-74254	2	11	-	-	SYM
bibechana-74254	2	12	115	115	NUM
bibechana-74254	2	13	issn	issn	PROPN
bibechana-74254	2	14	2091	2091	NUM
bibechana-74254	2	15	-	-	SYM
bibechana-74254	2	16	0762	0762	NUM
bibechana-74254	2	17	(	(	PUNCT
bibechana-74254	2	18	print	print	NOUN
bibechana-74254	2	19	)	)	PUNCT
bibechana-74254	2	20	,	,	PUNCT
bibechana-74254	2	21	2382	2382	NUM
bibechana-74254	2	22	-	-	SYM
bibechana-74254	2	23	5340	5340	NUM
bibechana-74254	2	24	(	(	PUNCT
bibechana-74254	2	25	online	online	ADJ
bibechana-74254	2	26	)	)	PUNCT
bibechana-74254	2	27	journal	journal	NOUN
bibechana-74254	2	28	homepage	homepage	NOUN
bibechana-74254	2	29	:	:	PUNCT
bibechana-74254	2	30	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-74254	2	31	publisher	publisher	NOUN
bibechana-74254	2	32	:	:	PUNCT
bibechana-74254	2	33	dept	dept	NOUN
bibechana-74254	2	34	.	.	PROPN
bibechana-74254	2	35	of	of	ADP
bibechana-74254	2	36	phys	phy	NOUN
bibechana-74254	2	37	.	.	PUNCT
bibechana-74254	2	38	,	,	PUNCT
bibechana-74254	3	1	mahendra	mahendra	PROPN
bibechana-74254	3	2	morang	morang	PROPN
bibechana-74254	3	3	a.	a.	PROPN
bibechana-74254	3	4	m.	m.	PROPN
bibechana-74254	3	5	campus	campus	PROPN
bibechana-74254	3	6	(	(	PUNCT
bibechana-74254	3	7	tribhuvan	tribhuvan	NOUN
bibechana-74254	3	8	university)biratnagar	university)biratnagar	NUM
bibechana-74254	3	9	structural	structural	ADJ
bibechana-74254	3	10	characterization	characterization	NOUN
bibechana-74254	3	11	of	of	ADP
bibechana-74254	3	12	hdac2	hdac2	NOUN
bibechana-74254	3	13	-	-	PUNCT
bibechana-74254	3	14	mta1	mta1	PROPN
bibechana-74254	3	15	complex	complex	ADJ
bibechana-74254	3	16	narayan	narayan	PROPN
bibechana-74254	3	17	gautam1,2	gautam1,2	PROPN
bibechana-74254	3	18	,	,	PUNCT
bibechana-74254	3	19	narayan	narayan	NOUN
bibechana-74254	3	20	p.	p.	NOUN
bibechana-74254	3	21	adhikari1	adhikari1	PROPN
bibechana-74254	4	1	1central	1central	NUM
bibechana-74254	4	2	department	department	PROPN
bibechana-74254	4	3	of	of	ADP
bibechana-74254	4	4	physics	physics	PROPN
bibechana-74254	4	5	,	,	PUNCT
bibechana-74254	4	6	tribhuvan	tribhuvan	PROPN
bibechana-74254	4	7	university	university	PROPN
bibechana-74254	4	8	,	,	PUNCT
bibechana-74254	4	9	kirtipur	kirtipur	NOUN
bibechana-74254	4	10	,	,	PUNCT
bibechana-74254	4	11	nepal	nepal	ADJ
bibechana-74254	4	12	2tri	2tri	PROPN
bibechana-74254	4	13	-	-	PUNCT
bibechana-74254	4	14	chandra	chandra	PROPN
bibechana-74254	4	15	multiple	multiple	ADJ
bibechana-74254	4	16	campus	campus	PROPN
bibechana-74254	4	17	,	,	PUNCT
bibechana-74254	4	18	tribhuvan	tribhuvan	PROPN
bibechana-74254	4	19	university	university	PROPN
bibechana-74254	4	20	,	,	PUNCT
bibechana-74254	4	21	kathmandu	kathmandu	NOUN
bibechana-74254	4	22	44613	44613	NUM
bibechana-74254	4	23	,	,	PUNCT
bibechana-74254	4	24	nepal	nepal	ADJ
bibechana-74254	4	25	∗corresponding	∗corresponde	VERB
bibechana-74254	4	26	author	author	NOUN
bibechana-74254	4	27	.	.	PUNCT
bibechana-74254	5	1	email:narayan.adhikari@cdp.tu.edu.np	email:narayan.adhikari@cdp.tu.edu.np	PROPN
bibechana-74254	5	2	abstract	abstract	ADJ
bibechana-74254	5	3	histone	histone	PROPN
bibechana-74254	5	4	deacetylases	deacetylase	NOUN
bibechana-74254	5	5	are	be	AUX
bibechana-74254	5	6	recruited	recruit	VERB
bibechana-74254	5	7	to	to	ADP
bibechana-74254	5	8	specific	specific	ADJ
bibechana-74254	5	9	transcriptional	transcriptional	ADJ
bibechana-74254	5	10	repression	repression	NOUN
bibechana-74254	5	11	complexes	complexe	VERB
bibechana-74254	5	12	through	through	ADP
bibechana-74254	5	13	interactions	interaction	NOUN
bibechana-74254	5	14	with	with	ADP
bibechana-74254	5	15	corepressor	corepressor	NOUN
bibechana-74254	5	16	proteins	protein	NOUN
bibechana-74254	5	17	.	.	PUNCT
bibechana-74254	6	1	this	this	DET
bibechana-74254	6	2	recruitment	recruitment	NOUN
bibechana-74254	6	3	leads	lead	VERB
bibechana-74254	6	4	to	to	ADP
bibechana-74254	6	5	chromatin	chromatin	NOUN
bibechana-74254	6	6	condensation	condensation	NOUN
bibechana-74254	6	7	and	and	CCONJ
bibechana-74254	6	8	transcriptional	transcriptional	ADJ
bibechana-74254	6	9	silencing	silencing	NOUN
bibechana-74254	6	10	.	.	PUNCT
bibechana-74254	7	1	in	in	ADP
bibechana-74254	7	2	this	this	DET
bibechana-74254	7	3	study	study	NOUN
bibechana-74254	7	4	,	,	PUNCT
bibechana-74254	7	5	we	we	PRON
bibechana-74254	7	6	modeled	model	VERB
bibechana-74254	7	7	the	the	DET
bibechana-74254	7	8	complex	complex	ADJ
bibechana-74254	7	9	structure	structure	NOUN
bibechana-74254	7	10	of	of	ADP
bibechana-74254	7	11	hdac2	hdac2	NOUN
bibechana-74254	7	12	with	with	ADP
bibechana-74254	7	13	mta1	mta1	NOUN
bibechana-74254	7	14	and	and	CCONJ
bibechana-74254	7	15	investigated	investigate	VERB
bibechana-74254	7	16	the	the	DET
bibechana-74254	7	17	hdac2	hdac2	NOUN
bibechana-74254	7	18	and	and	CCONJ
bibechana-74254	7	19	mta1	mta1	NOUN
bibechana-74254	7	20	interactions	interaction	NOUN
bibechana-74254	7	21	using	use	VERB
bibechana-74254	7	22	all	all	DET
bibechana-74254	7	23	-	-	PUNCT
bibechana-74254	7	24	atom	atom	NOUN
bibechana-74254	7	25	molecular	molecular	ADJ
bibechana-74254	7	26	dynamics	dynamic	NOUN
bibechana-74254	7	27	(	(	PUNCT
bibechana-74254	7	28	md	md	PROPN
bibechana-74254	7	29	)	)	PUNCT
bibechana-74254	7	30	simulation	simulation	NOUN
bibechana-74254	7	31	.	.	PUNCT
bibechana-74254	8	1	our	our	PRON
bibechana-74254	8	2	results	result	NOUN
bibechana-74254	8	3	show	show	VERB
bibechana-74254	8	4	that	that	SCONJ
bibechana-74254	8	5	the	the	DET
bibechana-74254	8	6	elm2	elm2	NOUN
bibechana-74254	8	7	-	-	PUNCT
bibechana-74254	8	8	sant	sant	NOUN
bibechana-74254	8	9	domains	domain	NOUN
bibechana-74254	8	10	of	of	ADP
bibechana-74254	8	11	mta1	mta1	PROPN
bibechana-74254	8	12	wrap	wrap	VERB
bibechana-74254	8	13	completely	completely	ADV
bibechana-74254	8	14	around	around	ADP
bibechana-74254	8	15	hdac2	hdac2	NOUN
bibechana-74254	8	16	.	.	PUNCT
bibechana-74254	9	1	we	we	PRON
bibechana-74254	9	2	identified	identify	VERB
bibechana-74254	9	3	the	the	DET
bibechana-74254	9	4	different	different	ADJ
bibechana-74254	9	5	types	type	NOUN
bibechana-74254	9	6	of	of	ADP
bibechana-74254	9	7	interactions	interaction	NOUN
bibechana-74254	9	8	such	such	ADJ
bibechana-74254	9	9	as	as	ADP
bibechana-74254	9	10	hydrogen	hydrogen	NOUN
bibechana-74254	9	11	bonds	bond	NOUN
bibechana-74254	9	12	,	,	PUNCT
bibechana-74254	9	13	salt	salt	NOUN
bibechana-74254	9	14	bridges	bridge	NOUN
bibechana-74254	9	15	,	,	PUNCT
bibechana-74254	9	16	and	and	CCONJ
bibechana-74254	9	17	hydrophobic	hydrophobic	NOUN
bibechana-74254	9	18	interactions	interaction	NOUN
bibechana-74254	9	19	.	.	PUNCT
bibechana-74254	10	1	specifically	specifically	ADV
bibechana-74254	10	2	,	,	PUNCT
bibechana-74254	10	3	glu186	glu186	PROPN
bibechana-74254	10	4	,	,	PUNCT
bibechana-74254	10	5	glu147	glu147	NOUN
bibechana-74254	10	6	,	,	PUNCT
bibechana-74254	10	7	glu163	glu163	NOUN
bibechana-74254	10	8	,	,	PUNCT
bibechana-74254	10	9	lys166	lys166	PROPN
bibechana-74254	10	10	,	,	PUNCT
bibechana-74254	10	11	and	and	CCONJ
bibechana-74254	10	12	lys124	lys124	PROPN
bibechana-74254	10	13	amino	amino	NOUN
bibechana-74254	10	14	acid	acid	NOUN
bibechana-74254	10	15	residues	residue	NOUN
bibechana-74254	10	16	of	of	ADP
bibechana-74254	10	17	hdac2	hdac2	NOUN
bibechana-74254	10	18	form	form	NOUN
bibechana-74254	10	19	both	both	PRON
bibechana-74254	10	20	hydrogen	hydrogen	NOUN
bibechana-74254	10	21	bond	bond	NOUN
bibechana-74254	10	22	and	and	CCONJ
bibechana-74254	10	23	salt	salt	NOUN
bibechana-74254	10	24	bridge	bridge	NOUN
bibechana-74254	10	25	interactions	interaction	NOUN
bibechana-74254	10	26	with	with	ADP
bibechana-74254	10	27	arg168	arg168	PROPN
bibechana-74254	10	28	,	,	PUNCT
bibechana-74254	10	29	arg189	arg189	PROPN
bibechana-74254	10	30	,	,	PUNCT
bibechana-74254	10	31	asp187	asp187	PROPN
bibechana-74254	10	32	,	,	PUNCT
bibechana-74254	10	33	and	and	CCONJ
bibechana-74254	10	34	glu195	glu195	PROPN
bibechana-74254	10	35	amino	amino	NOUN
bibechana-74254	10	36	acid	acid	NOUN
bibechana-74254	10	37	residues	residue	NOUN
bibechana-74254	10	38	of	of	ADP
bibechana-74254	10	39	mta1	mta1	NOUN
bibechana-74254	10	40	.	.	PUNCT
bibechana-74254	11	1	additionally	additionally	ADV
bibechana-74254	11	2	,	,	PUNCT
bibechana-74254	11	3	tyr15	tyr15	NOUN
bibechana-74254	11	4	amino	amino	NOUN
bibechana-74254	11	5	acid	acid	NOUN
bibechana-74254	11	6	of	of	ADP
bibechana-74254	11	7	hdac2	hdac2	NOUN
bibechana-74254	11	8	form	form	NOUN
bibechana-74254	11	9	hydrogen	hydrogen	NOUN
bibechana-74254	11	10	bonds	bond	NOUN
bibechana-74254	11	11	with	with	ADP
bibechana-74254	11	12	glu195	glu195	NOUN
bibechana-74254	11	13	amino	amino	NOUN
bibechana-74254	11	14	acid	acid	NOUN
bibechana-74254	11	15	of	of	ADP
bibechana-74254	11	16	mta1	mta1	PROPN
bibechana-74254	11	17	.	.	PUNCT
bibechana-74254	12	1	in	in	ADP
bibechana-74254	12	2	addition	addition	NOUN
bibechana-74254	12	3	to	to	ADP
bibechana-74254	12	4	hydrogen	hydrogen	NOUN
bibechana-74254	12	5	bond	bond	NOUN
bibechana-74254	12	6	and	and	CCONJ
bibechana-74254	12	7	salt	salt	NOUN
bibechana-74254	12	8	bridge	bridge	NOUN
bibechana-74254	12	9	interactions	interaction	NOUN
bibechana-74254	12	10	,	,	PUNCT
bibechana-74254	12	11	we	we	PRON
bibechana-74254	12	12	also	also	ADV
bibechana-74254	12	13	analyzed	analyze	VERB
bibechana-74254	12	14	hydrophobic	hydrophobic	NOUN
bibechana-74254	12	15	interaction	interaction	NOUN
bibechana-74254	12	16	.	.	PUNCT
bibechana-74254	13	1	keywords	keyword	VERB
bibechana-74254	13	2	hdac2	hdac2	NOUN
bibechana-74254	13	3	,	,	PUNCT
bibechana-74254	13	4	mta1	mta1	NOUN
bibechana-74254	13	5	,	,	PUNCT
bibechana-74254	13	6	molecular	molecular	ADJ
bibechana-74254	13	7	dynamics	dynamic	NOUN
bibechana-74254	13	8	simulation	simulation	NOUN
bibechana-74254	13	9	,	,	PUNCT
bibechana-74254	13	10	salt	salt	NOUN
bibechana-74254	13	11	bridge	bridge	NOUN
bibechana-74254	13	12	,	,	PUNCT
bibechana-74254	13	13	hydrogen	hydrogen	NOUN
bibechana-74254	13	14	bonding	bonding	NOUN
bibechana-74254	13	15	,	,	PUNCT
bibechana-74254	13	16	hydrophobic	hydrophobic	NOUN
bibechana-74254	13	17	interactions	interaction	NOUN
bibechana-74254	13	18	,	,	PUNCT
bibechana-74254	13	19	solvent	solvent	NOUN
bibechana-74254	13	20	-	-	PUNCT
bibechana-74254	13	21	accessible	accessible	ADJ
bibechana-74254	13	22	surface	surface	NOUN
bibechana-74254	13	23	area	area	NOUN
bibechana-74254	13	24	,	,	PUNCT
bibechana-74254	13	25	mm	mm	PROPN
bibechana-74254	13	26	-	-	PUNCT
bibechana-74254	13	27	gbsa	gbsa	ADJ
bibechana-74254	13	28	article	article	NOUN
bibechana-74254	13	29	information	information	NOUN
bibechana-74254	13	30	manuscript	manuscript	NOUN
bibechana-74254	13	31	received	receive	VERB
bibechana-74254	13	32	:	:	PUNCT
bibechana-74254	13	33	january	january	PROPN
bibechana-74254	13	34	19	19	NUM
bibechana-74254	13	35	,	,	PUNCT
bibechana-74254	13	36	2025	2025	NUM
bibechana-74254	13	37	;	;	PUNCT
bibechana-74254	13	38	revised	revise	VERB
bibechana-74254	13	39	:	:	PUNCT
bibechana-74254	13	40	february	february	PROPN
bibechana-74254	13	41	6	6	NUM
bibechana-74254	13	42	,	,	PUNCT
bibechana-74254	13	43	2025	2025	NUM
bibechana-74254	13	44	;	;	PUNCT
bibechana-74254	13	45	accepted	accept	VERB
bibechana-74254	13	46	:	:	PUNCT
bibechana-74254	13	47	february	february	NOUN
bibechana-74254	13	48	10	10	NUM
bibechana-74254	13	49	,	,	PUNCT
bibechana-74254	13	50	2025	2025	NUM
bibechana-74254	13	51	doi	doi	X
bibechana-74254	13	52	https://doi.org/10.3126/bibechana.v22i2.74254	https://doi.org/10.3126/bibechana.v22i2.74254	NUM
bibechana-74254	14	1	this	this	DET
bibechana-74254	14	2	work	work	NOUN
bibechana-74254	14	3	is	be	AUX
bibechana-74254	14	4	licensed	license	VERB
bibechana-74254	14	5	under	under	ADP
bibechana-74254	14	6	the	the	DET
bibechana-74254	14	7	creative	creative	ADJ
bibechana-74254	14	8	commons	common	NOUN
bibechana-74254	14	9	cc	cc	ADP
bibechana-74254	14	10	by	by	ADP
bibechana-74254	14	11	-	-	PUNCT
bibechana-74254	14	12	nc	nc	NOUN
bibechana-74254	14	13	license	license	NOUN
bibechana-74254	14	14	.	.	PUNCT
bibechana-74254	15	1	https://creativecommons	https://creativecommon	NOUN
bibechana-74254	15	2	.	.	PUNCT
bibechana-74254	15	3	org	org	ADJ
bibechana-74254	15	4	/	/	SYM
bibechana-74254	15	5	licenses	license	NOUN
bibechana-74254	15	6	/	/	SYM
bibechana-74254	15	7	by	by	ADP
bibechana-74254	15	8	-	-	PUNCT
bibechana-74254	15	9	nc/4.0/	nc/4.0/	NOUN
bibechana-74254	15	10	1	1	NUM
bibechana-74254	15	11	introduction	introduction	NOUN
bibechana-74254	15	12	nucleosomes	nucleosome	NOUN
bibechana-74254	15	13	are	be	AUX
bibechana-74254	15	14	the	the	DET
bibechana-74254	15	15	basic	basic	ADJ
bibechana-74254	15	16	units	unit	NOUN
bibechana-74254	15	17	of	of	ADP
bibechana-74254	15	18	chromatin	chromatin	NOUN
bibechana-74254	15	19	that	that	PRON
bibechana-74254	15	20	consist	consist	VERB
bibechana-74254	15	21	of	of	ADP
bibechana-74254	15	22	histone	histone	NOUN
bibechana-74254	15	23	and	and	CCONJ
bibechana-74254	15	24	non	non	ADJ
bibechana-74254	15	25	-	-	ADJ
bibechana-74254	15	26	histone	histone	ADJ
bibechana-74254	15	27	proteins	protein	NOUN
bibechana-74254	15	28	in	in	ADP
bibechana-74254	15	29	eukaryotic	eukaryotic	ADJ
bibechana-74254	15	30	cells	cell	NOUN
bibechana-74254	15	31	.	.	PUNCT
bibechana-74254	16	1	dna	dna	PROPN
bibechana-74254	16	2	is	be	AUX
bibechana-74254	16	3	wrapped	wrap	VERB
bibechana-74254	16	4	around	around	ADP
bibechana-74254	16	5	histones	histone	NOUN
bibechana-74254	16	6	that	that	PRON
bibechana-74254	16	7	help	help	VERB
bibechana-74254	16	8	the	the	DET
bibechana-74254	16	9	dna	dna	PROPN
bibechana-74254	16	10	fit	fit	VERB
bibechana-74254	16	11	into	into	ADP
bibechana-74254	16	12	the	the	DET
bibechana-74254	16	13	nucleus	nucleus	NOUN
bibechana-74254	16	14	.	.	PUNCT
bibechana-74254	17	1	transcription	transcription	NOUN
bibechana-74254	17	2	factors	factor	NOUN
bibechana-74254	17	3	are	be	AUX
bibechana-74254	17	4	proteins	protein	NOUN
bibechana-74254	17	5	that	that	PRON
bibechana-74254	17	6	interact	interact	VERB
bibechana-74254	17	7	with	with	ADP
bibechana-74254	17	8	the	the	DET
bibechana-74254	17	9	dna	dna	NOUN
bibechana-74254	17	10	and	and	CCONJ
bibechana-74254	17	11	help	help	VERB
bibechana-74254	17	12	to	to	PART
bibechana-74254	17	13	remodel	remodel	VERB
bibechana-74254	17	14	the	the	DET
bibechana-74254	17	15	chromatin	chromatin	NOUN
bibechana-74254	17	16	structure	structure	NOUN
bibechana-74254	17	17	by	by	ADP
bibechana-74254	17	18	repressing	repress	VERB
bibechana-74254	17	19	or	or	CCONJ
bibechana-74254	17	20	expressing	express	VERB
bibechana-74254	17	21	the	the	DET
bibechana-74254	17	22	transcription	transcription	NOUN
bibechana-74254	17	23	.	.	PUNCT
bibechana-74254	18	1	when	when	SCONJ
bibechana-74254	18	2	the	the	DET
bibechana-74254	18	3	lysine	lysine	NOUN
bibechana-74254	18	4	residues	residue	VERB
bibechana-74254	18	5	on	on	ADP
bibechana-74254	18	6	the	the	DET
bibechana-74254	18	7	amino	amino	NOUN
bibechana-74254	18	8	-	-	PUNCT
bibechana-74254	18	9	terminal	terminal	NOUN
bibechana-74254	18	10	of	of	ADP
bibechana-74254	18	11	histone	histone	NOUN
bibechana-74254	18	12	are	be	AUX
bibechana-74254	18	13	acetylated	acetylate	VERB
bibechana-74254	18	14	,	,	PUNCT
bibechana-74254	18	15	the	the	DET
bibechana-74254	18	16	interaction	interaction	NOUN
bibechana-74254	18	17	between	between	ADP
bibechana-74254	18	18	the	the	DET
bibechana-74254	18	19	histones	histone	NOUN
bibechana-74254	18	20	and	and	CCONJ
bibechana-74254	18	21	dna	dna	NOUN
bibechana-74254	18	22	is	be	AUX
bibechana-74254	18	23	weakened	weaken	VERB
bibechana-74254	18	24	,	,	PUNCT
bibechana-74254	18	25	and	and	CCONJ
bibechana-74254	18	26	the	the	DET
bibechana-74254	18	27	chromatin	chromatin	NOUN
bibechana-74254	18	28	is	be	AUX
bibechana-74254	18	29	accessible	accessible	ADJ
bibechana-74254	18	30	for	for	ADP
bibechana-74254	18	31	the	the	DET
bibechana-74254	18	32	transcription	transcription	NOUN
bibechana-74254	18	33	.	.	PUNCT
bibechana-74254	19	1	the	the	DET
bibechana-74254	19	2	acetylation	acetylation	NOUN
bibechana-74254	19	3	is	be	AUX
bibechana-74254	19	4	possible	possible	ADJ
bibechana-74254	19	5	due	due	ADP
bibechana-74254	19	6	to	to	ADP
bibechana-74254	19	7	the	the	DET
bibechana-74254	19	8	enzyme	enzyme	NOUN
bibechana-74254	19	9	hats	hat	NOUN
bibechana-74254	19	10	.	.	PUNCT
bibechana-74254	20	1	when	when	SCONJ
bibechana-74254	20	2	the	the	DET
bibechana-74254	20	3	acetyl	acetyl	NOUN
bibechana-74254	20	4	group	group	NOUN
bibechana-74254	20	5	is	be	AUX
bibechana-74254	20	6	removed	remove	VERB
bibechana-74254	20	7	with	with	ADP
bibechana-74254	20	8	the	the	DET
bibechana-74254	20	9	help	help	NOUN
bibechana-74254	20	10	of	of	ADP
bibechana-74254	20	11	hdacs	hdac	NOUN
bibechana-74254	20	12	from	from	ADP
bibechana-74254	20	13	the	the	DET
bibechana-74254	20	14	lysine	lysine	NOUN
bibechana-74254	20	15	of	of	ADP
bibechana-74254	20	16	histones	histone	NOUN
bibechana-74254	20	17	on	on	ADP
bibechana-74254	20	18	the	the	DET
bibechana-74254	20	19	amino	amino	NOUN
bibechana-74254	20	20	-	-	PUNCT
bibechana-74254	20	21	terminal	terminal	NOUN
bibechana-74254	20	22	,	,	PUNCT
bibechana-74254	20	23	the	the	DET
bibechana-74254	20	24	interaction	interaction	NOUN
bibechana-74254	20	25	of	of	ADP
bibechana-74254	20	26	the	the	DET
bibechana-74254	20	27	histone	histone	NOUN
bibechana-74254	20	28	with	with	ADP
bibechana-74254	20	29	dna	dna	PROPN
bibechana-74254	20	30	is	be	AUX
bibechana-74254	20	31	strengthened	strengthen	VERB
bibechana-74254	20	32	.	.	PUNCT
bibechana-74254	21	1	at	at	ADP
bibechana-74254	21	2	that	that	DET
bibechana-74254	21	3	time	time	NOUN
bibechana-74254	21	4	,	,	PUNCT
bibechana-74254	21	5	the	the	DET
bibechana-74254	21	6	chromatin	chromatin	NOUN
bibechana-74254	21	7	is	be	AUX
bibechana-74254	21	8	inaccessible	inaccessible	ADJ
bibechana-74254	21	9	for	for	ADP
bibechana-74254	21	10	the	the	DET
bibechana-74254	21	11	transcription	transcription	NOUN
bibechana-74254	21	12	.	.	PUNCT
bibechana-74254	22	1	many	many	ADJ
bibechana-74254	22	2	studies	study	NOUN
bibechana-74254	22	3	have	have	AUX
bibechana-74254	22	4	predicted	predict	VERB
bibechana-74254	22	5	that	that	SCONJ
bibechana-74254	22	6	there	there	PRON
bibechana-74254	22	7	is	be	VERB
bibechana-74254	22	8	an	an	DET
bibechana-74254	22	9	important	important	ADJ
bibechana-74254	22	10	link	link	NOUN
bibechana-74254	22	11	between	between	ADP
bibechana-74254	22	12	hdacs	hdac	NOUN
bibechana-74254	22	13	and	and	CCONJ
bibechana-74254	22	14	cancer	cancer	NOUN
bibechana-74254	22	15	.	.	PUNCT
bibechana-74254	23	1	hdacrelated	hdacrelate	VERB
bibechana-74254	23	2	interactions	interaction	NOUN
bibechana-74254	23	3	are	be	AUX
bibechana-74254	23	4	known	know	VERB
bibechana-74254	23	5	to	to	PART
bibechana-74254	23	6	be	be	AUX
bibechana-74254	23	7	associated	associate	VERB
bibechana-74254	23	8	with	with	ADP
bibechana-74254	23	9	transcriptional	transcriptional	ADJ
bibechana-74254	23	10	repression	repression	NOUN
bibechana-74254	23	11	of	of	ADP
bibechana-74254	23	12	some	some	DET
bibechana-74254	23	13	genes	gene	NOUN
bibechana-74254	23	14	,	,	PUNCT
bibechana-74254	23	15	and	and	CCONJ
bibechana-74254	23	16	abnormal	abnormal	ADJ
bibechana-74254	23	17	recruitment	recruitment	NOUN
bibechana-74254	23	18	of	of	ADP
bibechana-74254	23	19	hdacs	hdac	NOUN
bibechana-74254	23	20	to	to	ADP
bibechana-74254	23	21	their	their	PRON
bibechana-74254	23	22	promoter	promoter	NOUN
bibechana-74254	23	23	is	be	AUX
bibechana-74254	23	24	con108	con108	VERB
bibechana-74254	23	25	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-74254	23	26	narayan.adhikari@cdp.tu.edu.np	narayan.adhikari@cdp.tu.edu.np	PROPN
bibechana-74254	23	27	https://doi.org/10.3126/bibechana.v22i2.74254	https://doi.org/10.3126/bibechana.v22i2.74254	NUM
bibechana-74254	23	28	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
bibechana-74254	23	29	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PROPN
bibechana-74254	23	30	narayan	narayan	NOUN
bibechana-74254	23	31	gautam	gautam	PROPN
bibechana-74254	23	32	and	and	CCONJ
bibechana-74254	23	33	narayan	narayan	PROPN
bibechana-74254	23	34	p.	p.	NOUN
bibechana-74254	23	35	adhikari/	adhikari/	NUM
bibechana-74254	23	36	bibechana	bibechana	NOUN
bibechana-74254	23	37	22	22	NUM
bibechana-74254	23	38	(	(	PUNCT
bibechana-74254	23	39	2025	2025	NUM
bibechana-74254	23	40	)	)	PUNCT
bibechana-74254	23	41	108	108	NUM
bibechana-74254	23	42	-	-	SYM
bibechana-74254	23	43	115	115	NUM
bibechana-74254	23	44	109	109	NUM
bibechana-74254	23	45	tributed	tribute	VERB
bibechana-74254	23	46	to	to	ADP
bibechana-74254	23	47	the	the	DET
bibechana-74254	23	48	tumorgenesis	tumorgenesis	NOUN
bibechana-74254	23	49	.	.	PUNCT
bibechana-74254	24	1	hdac	hdac	PROPN
bibechana-74254	24	2	(	(	PUNCT
bibechana-74254	24	3	nurd	nurd	PROPN
bibechana-74254	24	4	complex	complex	PROPN
bibechana-74254	24	5	)	)	PUNCT
bibechana-74254	24	6	with	with	ADP
bibechana-74254	24	7	that	that	PRON
bibechana-74254	24	8	of	of	ADP
bibechana-74254	24	9	mta1	mta1	NOUN
bibechana-74254	24	10	have	have	AUX
bibechana-74254	24	11	indicated	indicate	VERB
bibechana-74254	24	12	a	a	DET
bibechana-74254	24	13	possible	possible	ADJ
bibechana-74254	24	14	function	function	NOUN
bibechana-74254	24	15	of	of	ADP
bibechana-74254	24	16	hdacs	hdac	NOUN
bibechana-74254	24	17	in	in	ADP
bibechana-74254	24	18	tumor	tumor	NOUN
bibechana-74254	24	19	progression	progression	NOUN
bibechana-74254	24	20	.	.	PUNCT
bibechana-74254	25	1	mta1	mta1	NOUN
bibechana-74254	25	2	also	also	ADV
bibechana-74254	25	3	physically	physically	ADV
bibechana-74254	25	4	interacts	interact	VERB
bibechana-74254	25	5	with	with	ADP
bibechana-74254	25	6	hdac1	hdac1	NOUN
bibechana-74254	25	7	.	.	PUNCT
bibechana-74254	26	1	mta1	mta1	PROPN
bibechana-74254	26	2	is	be	AUX
bibechana-74254	26	3	a	a	DET
bibechana-74254	26	4	target	target	NOUN
bibechana-74254	26	5	of	of	ADP
bibechana-74254	26	6	heregulin	heregulin	PROPN
bibechana-74254	26	7	(	(	PUNCT
bibechana-74254	26	8	hrg	hrg	PROPN
bibechana-74254	26	9	)	)	PUNCT
bibechana-74254	26	10	and	and	CCONJ
bibechana-74254	26	11	plays	play	VERB
bibechana-74254	26	12	a	a	DET
bibechana-74254	26	13	significant	significant	ADJ
bibechana-74254	26	14	role	role	NOUN
bibechana-74254	26	15	in	in	ADP
bibechana-74254	26	16	the	the	DET
bibechana-74254	26	17	repression	repression	NOUN
bibechana-74254	26	18	of	of	ADP
bibechana-74254	26	19	estrogen	estrogen	NOUN
bibechana-74254	26	20	receptor	receptor	NOUN
bibechana-74254	26	21	(	(	PUNCT
bibechana-74254	26	22	er)mediated	er)mediate	VERB
bibechana-74254	26	23	transcription	transcription	NOUN
bibechana-74254	26	24	by	by	ADP
bibechana-74254	26	25	recruiting	recruit	VERB
bibechana-74254	26	26	hdacs	hdac	NOUN
bibechana-74254	26	27	[	[	X
bibechana-74254	26	28	1	1	NUM
bibechana-74254	26	29	]	]	PUNCT
bibechana-74254	26	30	.	.	PUNCT
bibechana-74254	27	1	the	the	DET
bibechana-74254	27	2	metastatic	metastatic	NOUN
bibechana-74254	27	3	is	be	AUX
bibechana-74254	27	4	regulated	regulate	VERB
bibechana-74254	27	5	by	by	ADP
bibechana-74254	27	6	different	different	ADJ
bibechana-74254	27	7	genes	gene	NOUN
bibechana-74254	27	8	.	.	PUNCT
bibechana-74254	28	1	out	out	ADP
bibechana-74254	28	2	of	of	ADP
bibechana-74254	28	3	these	these	DET
bibechana-74254	28	4	genes	gene	NOUN
bibechana-74254	28	5	,	,	PUNCT
bibechana-74254	28	6	mta	mta	PROPN
bibechana-74254	28	7	proteins	protein	NOUN
bibechana-74254	28	8	play	play	VERB
bibechana-74254	28	9	crucial	crucial	ADJ
bibechana-74254	28	10	roles	role	NOUN
bibechana-74254	28	11	in	in	ADP
bibechana-74254	28	12	the	the	DET
bibechana-74254	28	13	development	development	NOUN
bibechana-74254	28	14	and	and	CCONJ
bibechana-74254	28	15	spread	spread	VERB
bibechana-74254	28	16	of	of	ADP
bibechana-74254	28	17	cancer	cancer	NOUN
bibechana-74254	28	18	cells	cell	NOUN
bibechana-74254	28	19	[	[	X
bibechana-74254	28	20	2	2	NUM
bibechana-74254	28	21	,	,	PUNCT
bibechana-74254	28	22	3	3	NUM
bibechana-74254	28	23	]	]	PUNCT
bibechana-74254	28	24	.	.	PUNCT
bibechana-74254	29	1	histone	histone	NOUN
bibechana-74254	29	2	modification	modification	NOUN
bibechana-74254	29	3	is	be	AUX
bibechana-74254	29	4	one	one	NUM
bibechana-74254	29	5	of	of	ADP
bibechana-74254	29	6	the	the	DET
bibechana-74254	29	7	important	important	ADJ
bibechana-74254	29	8	epigenetic	epigenetic	ADJ
bibechana-74254	29	9	modifications	modification	NOUN
bibechana-74254	29	10	that	that	PRON
bibechana-74254	29	11	is	be	AUX
bibechana-74254	29	12	essential	essential	ADJ
bibechana-74254	29	13	for	for	ADP
bibechana-74254	29	14	the	the	DET
bibechana-74254	29	15	regulation	regulation	NOUN
bibechana-74254	29	16	of	of	ADP
bibechana-74254	29	17	gene	gene	NOUN
bibechana-74254	29	18	expression	expression	NOUN
bibechana-74254	29	19	.	.	PUNCT
bibechana-74254	30	1	histone	histone	NOUN
bibechana-74254	30	2	deacetylases	deacetylase	NOUN
bibechana-74254	30	3	(	(	PUNCT
bibechana-74254	30	4	hdacs	hdac	NOUN
bibechana-74254	30	5	)	)	PUNCT
bibechana-74254	30	6	are	be	AUX
bibechana-74254	30	7	enzymatic	enzymatic	ADJ
bibechana-74254	30	8	proteins	protein	NOUN
bibechana-74254	30	9	that	that	PRON
bibechana-74254	30	10	remove	remove	VERB
bibechana-74254	30	11	acetyl	acetyl	NOUN
bibechana-74254	30	12	groups	group	NOUN
bibechana-74254	30	13	from	from	ADP
bibechana-74254	30	14	histone	histone	NOUN
bibechana-74254	30	15	and	and	CCONJ
bibechana-74254	30	16	non	non	ADJ
bibechana-74254	30	17	-	-	ADJ
bibechana-74254	30	18	histone	histone	ADJ
bibechana-74254	30	19	proteins	protein	NOUN
bibechana-74254	30	20	which	which	PRON
bibechana-74254	30	21	repress	repress	VERB
bibechana-74254	30	22	the	the	DET
bibechana-74254	30	23	gene	gene	NOUN
bibechana-74254	30	24	expression	expression	NOUN
bibechana-74254	30	25	[	[	X
bibechana-74254	30	26	4,5	4,5	NUM
bibechana-74254	30	27	]	]	PUNCT
bibechana-74254	30	28	.	.	PUNCT
bibechana-74254	31	1	hdacs	hdac	NOUN
bibechana-74254	31	2	are	be	AUX
bibechana-74254	31	3	associated	associate	VERB
bibechana-74254	31	4	with	with	ADP
bibechana-74254	31	5	different	different	ADJ
bibechana-74254	31	6	biological	biological	ADJ
bibechana-74254	31	7	processes	process	NOUN
bibechana-74254	31	8	such	such	ADJ
bibechana-74254	31	9	as	as	ADP
bibechana-74254	31	10	cellular	cellular	ADJ
bibechana-74254	31	11	proliferation	proliferation	NOUN
bibechana-74254	31	12	,	,	PUNCT
bibechana-74254	31	13	apoptosis	apoptosis	NOUN
bibechana-74254	31	14	,	,	PUNCT
bibechana-74254	31	15	and	and	CCONJ
bibechana-74254	31	16	signal	signal	ADJ
bibechana-74254	31	17	transduction	transduction	NOUN
bibechana-74254	32	1	[	[	X
bibechana-74254	32	2	6	6	NUM
bibechana-74254	32	3	,	,	PUNCT
bibechana-74254	32	4	7	7	NUM
bibechana-74254	32	5	]	]	PUNCT
bibechana-74254	32	6	.	.	PUNCT
bibechana-74254	33	1	overexpression	overexpression	NOUN
bibechana-74254	33	2	and	and	CCONJ
bibechana-74254	33	3	abnormal	abnormal	ADJ
bibechana-74254	33	4	expression	expression	NOUN
bibechana-74254	33	5	of	of	ADP
bibechana-74254	33	6	hdacs	hdac	NOUN
bibechana-74254	33	7	to	to	ADP
bibechana-74254	33	8	their	their	PRON
bibechana-74254	33	9	promoter	promoter	NOUN
bibechana-74254	33	10	causes	cause	VERB
bibechana-74254	33	11	different	different	ADJ
bibechana-74254	33	12	types	type	NOUN
bibechana-74254	33	13	of	of	ADP
bibechana-74254	33	14	diseases	disease	NOUN
bibechana-74254	33	15	such	such	ADJ
bibechana-74254	33	16	as	as	ADP
bibechana-74254	33	17	cancer	cancer	NOUN
bibechana-74254	33	18	,	,	PUNCT
bibechana-74254	33	19	neurodegenerative	neurodegenerative	ADJ
bibechana-74254	33	20	disorders	disorder	NOUN
bibechana-74254	33	21	,	,	PUNCT
bibechana-74254	33	22	hiv	hiv	PROPN
bibechana-74254	33	23	,	,	PUNCT
bibechana-74254	33	24	diabetes	diabetes	NOUN
bibechana-74254	33	25	,	,	PUNCT
bibechana-74254	33	26	inflammation	inflammation	NOUN
bibechana-74254	33	27	and	and	CCONJ
bibechana-74254	33	28	cardiac	cardiac	ADJ
bibechana-74254	33	29	diseases	disease	NOUN
bibechana-74254	33	30	[	[	X
bibechana-74254	33	31	8	8	NUM
bibechana-74254	33	32	]	]	PUNCT
bibechana-74254	33	33	.	.	PUNCT
bibechana-74254	34	1	the	the	DET
bibechana-74254	34	2	inhibition	inhibition	NOUN
bibechana-74254	34	3	of	of	ADP
bibechana-74254	34	4	histone	histone	NOUN
bibechana-74254	34	5	deacetylases	deacetylase	NOUN
bibechana-74254	34	6	(	(	PUNCT
bibechana-74254	34	7	hdacs	hdac	NOUN
bibechana-74254	34	8	)	)	PUNCT
bibechana-74254	34	9	results	result	NOUN
bibechana-74254	34	10	in	in	ADP
bibechana-74254	34	11	increased	increase	VERB
bibechana-74254	34	12	acetylation	acetylation	NOUN
bibechana-74254	34	13	of	of	ADP
bibechana-74254	34	14	histones	histone	NOUN
bibechana-74254	34	15	and	and	CCONJ
bibechana-74254	34	16	various	various	ADJ
bibechana-74254	34	17	non	non	ADJ
bibechana-74254	34	18	-	-	ADJ
bibechana-74254	34	19	histone	histone	ADJ
bibechana-74254	34	20	proteins	protein	NOUN
bibechana-74254	34	21	,	,	PUNCT
bibechana-74254	34	22	encompassing	encompass	VERB
bibechana-74254	34	23	signaling	signal	VERB
bibechana-74254	34	24	mediators	mediator	NOUN
bibechana-74254	34	25	[	[	X
bibechana-74254	34	26	9	9	NUM
bibechana-74254	34	27	,	,	PUNCT
bibechana-74254	34	28	10	10	NUM
bibechana-74254	34	29	]	]	PUNCT
bibechana-74254	34	30	,	,	PUNCT
bibechana-74254	34	31	tumor	tumor	NOUN
bibechana-74254	34	32	suppressors	suppressor	NOUN
bibechana-74254	35	1	[	[	X
bibechana-74254	35	2	11	11	NUM
bibechana-74254	35	3	]	]	PUNCT
bibechana-74254	35	4	,	,	PUNCT
bibechana-74254	35	5	transcription	transcription	NOUN
bibechana-74254	35	6	factors	factor	NOUN
bibechana-74254	35	7	[	[	X
bibechana-74254	35	8	12	12	NUM
bibechana-74254	35	9	]	]	PUNCT
bibechana-74254	35	10	,	,	PUNCT
bibechana-74254	35	11	and	and	CCONJ
bibechana-74254	35	12	dna	dna	PROPN
bibechana-74254	35	13	repair	repair	NOUN
bibechana-74254	35	14	proteins	protein	NOUN
bibechana-74254	35	15	[	[	X
bibechana-74254	35	16	13	13	NUM
bibechana-74254	35	17	]	]	PUNCT
bibechana-74254	35	18	.	.	PUNCT
bibechana-74254	36	1	there	there	PRON
bibechana-74254	36	2	are	be	VERB
bibechana-74254	36	3	18	18	NUM
bibechana-74254	36	4	members	member	NOUN
bibechana-74254	36	5	in	in	ADP
bibechana-74254	36	6	the	the	DET
bibechana-74254	36	7	hdac	hdac	PROPN
bibechana-74254	36	8	family	family	NOUN
bibechana-74254	36	9	,	,	PUNCT
bibechana-74254	36	10	divided	divide	VERB
bibechana-74254	36	11	into	into	ADP
bibechana-74254	36	12	4	4	NUM
bibechana-74254	36	13	classes	class	NOUN
bibechana-74254	36	14	based	base	VERB
bibechana-74254	36	15	on	on	ADP
bibechana-74254	36	16	their	their	PRON
bibechana-74254	36	17	structure	structure	NOUN
bibechana-74254	36	18	and	and	CCONJ
bibechana-74254	36	19	function	function	NOUN
bibechana-74254	36	20	[	[	X
bibechana-74254	36	21	14	14	NUM
bibechana-74254	36	22	]	]	PUNCT
bibechana-74254	36	23	.	.	PUNCT
bibechana-74254	37	1	class	class	NOUN
bibechana-74254	37	2	i	i	PRON
bibechana-74254	37	3	includes	include	VERB
bibechana-74254	37	4	hdac1	hdac1	NOUN
bibechana-74254	37	5	-	-	PUNCT
bibechana-74254	37	6	3	3	NUM
bibechana-74254	37	7	and	and	CCONJ
bibechana-74254	37	8	8	8	NUM
bibechana-74254	37	9	;	;	PUNCT
bibechana-74254	37	10	class	class	NOUN
bibechana-74254	37	11	ii	ii	PROPN
bibechana-74254	37	12	includes	include	VERB
bibechana-74254	37	13	hdac4	hdac4	NOUN
bibechana-74254	37	14	-	-	PUNCT
bibechana-74254	37	15	7	7	NUM
bibechana-74254	37	16	,	,	PUNCT
bibechana-74254	37	17	9	9	NUM
bibechana-74254	37	18	,	,	PUNCT
bibechana-74254	37	19	and	and	CCONJ
bibechana-74254	37	20	10	10	NUM
bibechana-74254	37	21	;	;	PUNCT
bibechana-74254	37	22	class	class	NOUN
bibechana-74254	37	23	iii	iii	NOUN
bibechana-74254	37	24	includes	include	VERB
bibechana-74254	37	25	sirtuin	sirtuin	NOUN
bibechana-74254	37	26	enzymes	enzyme	NOUN
bibechana-74254	37	27	(	(	PUNCT
bibechana-74254	37	28	sirt	sirt	PROPN
bibechana-74254	37	29	1	1	NUM
bibechana-74254	37	30	-	-	SYM
bibechana-74254	37	31	7	7	NUM
bibechana-74254	37	32	)	)	PUNCT
bibechana-74254	37	33	;	;	PUNCT
bibechana-74254	37	34	and	and	CCONJ
bibechana-74254	37	35	class	class	NOUN
bibechana-74254	37	36	iv	iv	NOUN
bibechana-74254	37	37	comprises	comprise	VERB
bibechana-74254	37	38	only	only	ADV
bibechana-74254	37	39	hdac11	hdac11	NOUN
bibechana-74254	37	40	,	,	PUNCT
bibechana-74254	37	41	which	which	PRON
bibechana-74254	37	42	is	be	AUX
bibechana-74254	37	43	structurally	structurally	ADV
bibechana-74254	37	44	different	different	ADJ
bibechana-74254	37	45	from	from	ADP
bibechana-74254	37	46	the	the	DET
bibechana-74254	37	47	others	other	NOUN
bibechana-74254	37	48	.	.	PUNCT
bibechana-74254	38	1	within	within	ADP
bibechana-74254	38	2	class	class	PROPN
bibechana-74254	38	3	ii	ii	PROPN
bibechana-74254	38	4	,	,	PUNCT
bibechana-74254	38	5	there	there	PRON
bibechana-74254	38	6	are	be	VERB
bibechana-74254	38	7	further	further	ADJ
bibechana-74254	38	8	subdivisions	subdivision	NOUN
bibechana-74254	38	9	:	:	PUNCT
bibechana-74254	38	10	class	class	NOUN
bibechana-74254	38	11	iia	iia	NOUN
bibechana-74254	38	12	(	(	PUNCT
bibechana-74254	38	13	hdac4	hdac4	PROPN
bibechana-74254	38	14	,	,	PUNCT
bibechana-74254	38	15	5	5	NUM
bibechana-74254	38	16	,	,	PUNCT
bibechana-74254	38	17	7	7	NUM
bibechana-74254	38	18	,	,	PUNCT
bibechana-74254	38	19	and	and	CCONJ
bibechana-74254	38	20	9	9	NUM
bibechana-74254	38	21	)	)	PUNCT
bibechana-74254	38	22	and	and	CCONJ
bibechana-74254	38	23	class	class	NOUN
bibechana-74254	38	24	iib	iib	PROPN
bibechana-74254	38	25	(	(	PUNCT
bibechana-74254	38	26	hdac6	hdac6	PROPN
bibechana-74254	38	27	and	and	CCONJ
bibechana-74254	38	28	10	10	NUM
bibechana-74254	38	29	)	)	PUNCT
bibechana-74254	38	30	,	,	PUNCT
bibechana-74254	38	31	based	base	VERB
bibechana-74254	38	32	on	on	ADP
bibechana-74254	38	33	their	their	PRON
bibechana-74254	38	34	subcellular	subcellular	ADJ
bibechana-74254	38	35	localization	localization	NOUN
bibechana-74254	38	36	and	and	CCONJ
bibechana-74254	38	37	expression	expression	NOUN
bibechana-74254	38	38	patterns	pattern	NOUN
bibechana-74254	38	39	.	.	PUNCT
bibechana-74254	39	1	histone	histone	NOUN
bibechana-74254	39	2	deacetylases	deacetylase	NOUN
bibechana-74254	39	3	1	1	NUM
bibechana-74254	39	4	and	and	CCONJ
bibechana-74254	39	5	2	2	NUM
bibechana-74254	39	6	are	be	AUX
bibechana-74254	39	7	required	require	VERB
bibechana-74254	39	8	for	for	ADP
bibechana-74254	39	9	brain	brain	NOUN
bibechana-74254	39	10	development	development	NOUN
bibechana-74254	39	11	[	[	X
bibechana-74254	39	12	15	15	NUM
bibechana-74254	39	13	]	]	PUNCT
bibechana-74254	39	14	and	and	CCONJ
bibechana-74254	39	15	heart	heart	NOUN
bibechana-74254	39	16	development	development	NOUN
bibechana-74254	39	17	[	[	X
bibechana-74254	39	18	16	16	NUM
bibechana-74254	39	19	]	]	PUNCT
bibechana-74254	39	20	.	.	PUNCT
bibechana-74254	40	1	the	the	DET
bibechana-74254	40	2	different	different	ADJ
bibechana-74254	40	3	types	type	NOUN
bibechana-74254	40	4	of	of	ADP
bibechana-74254	40	5	mta	mta	PROPN
bibechana-74254	40	6	proteins	protein	NOUN
bibechana-74254	40	7	are	be	AUX
bibechana-74254	40	8	mta1	mta1	PROPN
bibechana-74254	40	9	,	,	PUNCT
bibechana-74254	40	10	mta2	mta2	NOUN
bibechana-74254	40	11	,	,	PUNCT
bibechana-74254	40	12	and	and	CCONJ
bibechana-74254	40	13	mta3	mta3	NOUN
bibechana-74254	41	1	[	[	X
bibechana-74254	41	2	17	17	NUM
bibechana-74254	41	3	,	,	PUNCT
bibechana-74254	41	4	18	18	NUM
bibechana-74254	41	5	]	]	PUNCT
bibechana-74254	41	6	.	.	PUNCT
bibechana-74254	42	1	mta1	mta1	PROPN
bibechana-74254	42	2	and	and	CCONJ
bibechana-74254	42	3	mta2	mta2	PROPN
bibechana-74254	42	4	are	be	AUX
bibechana-74254	42	5	expressed	express	VERB
bibechana-74254	42	6	ubiquitously	ubiquitously	ADV
bibechana-74254	42	7	but	but	CCONJ
bibechana-74254	42	8	the	the	DET
bibechana-74254	42	9	expression	expression	NOUN
bibechana-74254	42	10	pattern	pattern	NOUN
bibechana-74254	42	11	of	of	ADP
bibechana-74254	42	12	mta3	mta3	NOUN
bibechana-74254	42	13	is	be	AUX
bibechana-74254	42	14	restricted	restrict	VERB
bibechana-74254	42	15	.	.	PUNCT
bibechana-74254	43	1	mta1	mta1	PROPN
bibechana-74254	43	2	and	and	CCONJ
bibechana-74254	43	3	mta2	mta2	PROPN
bibechana-74254	43	4	are	be	AUX
bibechana-74254	43	5	mainly	mainly	ADV
bibechana-74254	43	6	found	find	VERB
bibechana-74254	43	7	in	in	ADP
bibechana-74254	43	8	the	the	DET
bibechana-74254	43	9	nucleus	nucleus	NOUN
bibechana-74254	43	10	[	[	X
bibechana-74254	43	11	19	19	NUM
bibechana-74254	43	12	]	]	PUNCT
bibechana-74254	43	13	.	.	PUNCT
bibechana-74254	44	1	mta1	mta1	PROPN
bibechana-74254	44	2	was	be	AUX
bibechana-74254	44	3	originally	originally	ADV
bibechana-74254	44	4	identified	identify	VERB
bibechana-74254	44	5	through	through	ADP
bibechana-74254	44	6	from	from	ADP
bibechana-74254	44	7	rat	rat	NOUN
bibechana-74254	44	8	metastatic	metastatic	ADJ
bibechana-74254	44	9	breast	breast	NOUN
bibechana-74254	44	10	tumors	tumor	NOUN
bibechana-74254	44	11	[	[	X
bibechana-74254	44	12	20	20	NUM
bibechana-74254	44	13	]	]	PUNCT
bibechana-74254	44	14	after	after	ADP
bibechana-74254	44	15	that	that	SCONJ
bibechana-74254	44	16	it	it	PRON
bibechana-74254	44	17	was	be	AUX
bibechana-74254	44	18	found	find	VERB
bibechana-74254	44	19	that	that	SCONJ
bibechana-74254	44	20	mta1	mta1	NOUN
bibechana-74254	44	21	is	be	AUX
bibechana-74254	44	22	widely	widely	ADV
bibechana-74254	44	23	up	up	ADV
bibechana-74254	44	24	-	-	PUNCT
bibechana-74254	44	25	regulated	regulate	VERB
bibechana-74254	44	26	in	in	ADP
bibechana-74254	44	27	human	human	ADJ
bibechana-74254	44	28	tumors	tumor	NOUN
bibechana-74254	45	1	[	[	X
bibechana-74254	45	2	21	21	NUM
bibechana-74254	45	3	]	]	PUNCT
bibechana-74254	45	4	.	.	PUNCT
bibechana-74254	46	1	mta1	mta1	PROPN
bibechana-74254	46	2	,	,	PUNCT
bibechana-74254	46	3	mta2	mta2	PROPN
bibechana-74254	46	4	,	,	PUNCT
bibechana-74254	46	5	including	include	VERB
bibechana-74254	46	6	hdac1	hdac1	NOUN
bibechana-74254	46	7	,	,	PUNCT
bibechana-74254	46	8	hdac2	hdac2	NOUN
bibechana-74254	46	9	are	be	AUX
bibechana-74254	46	10	the	the	DET
bibechana-74254	46	11	subunits	subunit	NOUN
bibechana-74254	46	12	of	of	ADP
bibechana-74254	46	13	nurd	nurd	PROPN
bibechana-74254	46	14	complex	complex	NOUN
bibechana-74254	46	15	that	that	PRON
bibechana-74254	46	16	provide	provide	VERB
bibechana-74254	46	17	the	the	DET
bibechana-74254	46	18	essential	essential	ADJ
bibechana-74254	46	19	role	role	NOUN
bibechana-74254	46	20	of	of	ADP
bibechana-74254	46	21	mta	mta	PROPN
bibechana-74254	46	22	and	and	CCONJ
bibechana-74254	46	23	hdacs	hdac	VERB
bibechana-74254	46	24	proteins	protein	NOUN
bibechana-74254	46	25	to	to	ADP
bibechana-74254	46	26	the	the	DET
bibechana-74254	46	27	chromatin	chromatin	NOUN
bibechana-74254	46	28	modification	modification	NOUN
bibechana-74254	47	1	[	[	X
bibechana-74254	47	2	22	22	NUM
bibechana-74254	47	3	,	,	PUNCT
bibechana-74254	47	4	23	23	NUM
bibechana-74254	47	5	]	]	PUNCT
bibechana-74254	47	6	.	.	PUNCT
bibechana-74254	48	1	there	there	PRON
bibechana-74254	48	2	are	be	VERB
bibechana-74254	48	3	different	different	ADJ
bibechana-74254	48	4	domains	domain	NOUN
bibechana-74254	48	5	in	in	ADP
bibechana-74254	48	6	the	the	DET
bibechana-74254	48	7	mta1	mta1	NOUN
bibechana-74254	48	8	protein	protein	NOUN
bibechana-74254	48	9	.	.	PUNCT
bibechana-74254	49	1	bromo	bromo	NOUN
bibechana-74254	49	2	-	-	PUNCT
bibechana-74254	49	3	adjacent	adjacent	ADJ
bibechana-74254	49	4	-	-	PUNCT
bibechana-74254	49	5	homology	homology	NOUN
bibechana-74254	49	6	(	(	PUNCT
bibechana-74254	49	7	bah	bah	INTJ
bibechana-74254	49	8	)	)	PUNCT
bibechana-74254	49	9	domain	domain	NOUN
bibechana-74254	49	10	,	,	PUNCT
bibechana-74254	49	11	the	the	DET
bibechana-74254	49	12	egl-27	egl-27	PROPN
bibechana-74254	49	13	and	and	CCONJ
bibechana-74254	49	14	mta1	mta1	PROPN
bibechana-74254	49	15	homology	homology	NOUN
bibechana-74254	49	16	2	2	NUM
bibechana-74254	49	17	(	(	PUNCT
bibechana-74254	49	18	elm2	elm2	NOUN
bibechana-74254	49	19	)	)	PUNCT
bibechana-74254	49	20	domain	domain	NOUN
bibechana-74254	49	21	,	,	PUNCT
bibechana-74254	49	22	and	and	CCONJ
bibechana-74254	49	23	the	the	DET
bibechana-74254	49	24	swi3	swi3	PROPN
bibechana-74254	49	25	,	,	PUNCT
bibechana-74254	49	26	ada2	ada2	PROPN
bibechana-74254	49	27	,	,	PUNCT
bibechana-74254	49	28	ncor	ncor	PROPN
bibechana-74254	49	29	,	,	PUNCT
bibechana-74254	49	30	and	and	CCONJ
bibechana-74254	49	31	tfiii	tfiii	NOUN
bibechana-74254	49	32	-	-	PUNCT
bibechana-74254	49	33	b	b	NOUN
bibechana-74254	49	34	(	(	PUNCT
bibechana-74254	49	35	sant	sant	NOUN
bibechana-74254	49	36	)	)	PUNCT
bibechana-74254	49	37	domains	domain	NOUN
bibechana-74254	49	38	are	be	AUX
bibechana-74254	49	39	the	the	DET
bibechana-74254	49	40	important	important	ADJ
bibechana-74254	49	41	domains	domain	NOUN
bibechana-74254	49	42	[	[	X
bibechana-74254	49	43	18	18	NUM
bibechana-74254	49	44	]	]	PUNCT
bibechana-74254	49	45	.	.	PUNCT
bibechana-74254	50	1	after	after	SCONJ
bibechana-74254	50	2	recruiting	recruit	VERB
bibechana-74254	50	3	hdacs	hdac	NOUN
bibechana-74254	50	4	,	,	PUNCT
bibechana-74254	50	5	the	the	DET
bibechana-74254	50	6	elm2	elm2	NOUN
bibechana-74254	50	7	domain	domain	NOUN
bibechana-74254	50	8	functions	function	NOUN
bibechana-74254	50	9	as	as	ADP
bibechana-74254	50	10	a	a	DET
bibechana-74254	50	11	transcriptional	transcriptional	ADJ
bibechana-74254	50	12	repression	repression	NOUN
bibechana-74254	50	13	domain	domain	NOUN
bibechana-74254	50	14	[	[	X
bibechana-74254	50	15	24	24	NUM
bibechana-74254	50	16	]	]	PUNCT
bibechana-74254	50	17	.	.	PUNCT
bibechana-74254	51	1	the	the	DET
bibechana-74254	51	2	elm2	elm2	NOUN
bibechana-74254	51	3	and	and	CCONJ
bibechana-74254	51	4	sant	sant	ADJ
bibechana-74254	51	5	domain	domain	NOUN
bibechana-74254	51	6	of	of	ADP
bibechana-74254	51	7	the	the	DET
bibechana-74254	51	8	mta1	mta1	NOUN
bibechana-74254	51	9	establish	establish	VERB
bibechana-74254	51	10	numerous	numerous	ADJ
bibechana-74254	51	11	interactions	interaction	NOUN
bibechana-74254	51	12	with	with	ADP
bibechana-74254	51	13	the	the	DET
bibechana-74254	51	14	hdac	hdac	NOUN
bibechana-74254	52	1	[	[	X
bibechana-74254	52	2	1,25	1,25	NUM
bibechana-74254	52	3	]	]	PUNCT
bibechana-74254	52	4	.	.	PUNCT
bibechana-74254	53	1	the	the	DET
bibechana-74254	53	2	structure	structure	NOUN
bibechana-74254	53	3	of	of	ADP
bibechana-74254	53	4	hdac1	hdac1	NOUN
bibechana-74254	53	5	in	in	ADP
bibechana-74254	53	6	complex	complex	NOUN
bibechana-74254	53	7	with	with	ADP
bibechana-74254	53	8	mta1	mta1	NOUN
bibechana-74254	53	9	from	from	ADP
bibechana-74254	53	10	the	the	DET
bibechana-74254	53	11	nurd	nurd	PROPN
bibechana-74254	53	12	complex	complex	NOUN
bibechana-74254	53	13	was	be	AUX
bibechana-74254	53	14	reported	report	VERB
bibechana-74254	53	15	by	by	ADP
bibechana-74254	53	16	millard	millard	PROPN
bibechana-74254	53	17	and	and	CCONJ
bibechana-74254	53	18	coauthors	coauthor	NOUN
bibechana-74254	53	19	in	in	ADP
bibechana-74254	53	20	2013	2013	NUM
bibechana-74254	53	21	.	.	PUNCT
bibechana-74254	54	1	they	they	PRON
bibechana-74254	54	2	reported	report	VERB
bibechana-74254	54	3	that	that	SCONJ
bibechana-74254	54	4	elm2	elm2	NOUN
bibechana-74254	54	5	-	-	PUNCT
bibechana-74254	54	6	sant	sant	NOUN
bibechana-74254	54	7	domains	domain	NOUN
bibechana-74254	54	8	from	from	ADP
bibechana-74254	54	9	mta1	mta1	NOUN
bibechana-74254	54	10	wrap	wrap	NOUN
bibechana-74254	54	11	completely	completely	ADV
bibechana-74254	54	12	around	around	ADP
bibechana-74254	54	13	hdac1	hdac1	NOUN
bibechana-74254	54	14	[	[	X
bibechana-74254	54	15	25	25	NUM
bibechana-74254	54	16	]	]	PUNCT
bibechana-74254	54	17	.	.	PUNCT
bibechana-74254	55	1	hdac2	hdac2	NOUN
bibechana-74254	55	2	contains	contain	VERB
bibechana-74254	55	3	many	many	ADJ
bibechana-74254	55	4	domains	domain	NOUN
bibechana-74254	55	5	with	with	ADP
bibechana-74254	55	6	defined	define	VERB
bibechana-74254	55	7	functions	function	NOUN
bibechana-74254	55	8	.	.	PUNCT
bibechana-74254	56	1	the	the	DET
bibechana-74254	56	2	catalytic	catalytic	ADJ
bibechana-74254	56	3	domain	domain	NOUN
bibechana-74254	56	4	common	common	ADJ
bibechana-74254	56	5	to	to	ADP
bibechana-74254	56	6	all	all	DET
bibechana-74254	56	7	class	class	NOUN
bibechana-74254	56	8	i	i	PRON
bibechana-74254	56	9	hdacs	hdac	VERB
bibechana-74254	56	10	is	be	AUX
bibechana-74254	56	11	formed	form	VERB
bibechana-74254	56	12	by	by	ADP
bibechana-74254	56	13	a	a	DET
bibechana-74254	56	14	stretch	stretch	NOUN
bibechana-74254	56	15	of	of	ADP
bibechana-74254	56	16	more	more	ADJ
bibechana-74254	56	17	than	than	ADP
bibechana-74254	56	18	300	300	NUM
bibechana-74254	56	19	amino	amino	NOUN
bibechana-74254	56	20	acids	acid	NOUN
bibechana-74254	56	21	constituting	constitute	VERB
bibechana-74254	56	22	a	a	DET
bibechana-74254	56	23	large	large	ADJ
bibechana-74254	56	24	portion	portion	NOUN
bibechana-74254	56	25	of	of	ADP
bibechana-74254	56	26	the	the	DET
bibechana-74254	56	27	protein	protein	NOUN
bibechana-74254	56	28	[	[	X
bibechana-74254	56	29	26	26	NUM
bibechana-74254	56	30	]	]	PUNCT
bibechana-74254	56	31	.	.	PUNCT
bibechana-74254	57	1	a	a	DET
bibechana-74254	57	2	nuclear	nuclear	ADJ
bibechana-74254	57	3	localization	localization	NOUN
bibechana-74254	57	4	signal	signal	NOUN
bibechana-74254	57	5	(	(	PUNCT
bibechana-74254	57	6	nls	nls	NOUN
bibechana-74254	57	7	)	)	PUNCT
bibechana-74254	57	8	at	at	ADP
bibechana-74254	57	9	the	the	DET
bibechana-74254	57	10	cterminus	cterminus	NOUN
bibechana-74254	57	11	can	can	AUX
bibechana-74254	57	12	only	only	ADV
bibechana-74254	57	13	be	be	AUX
bibechana-74254	57	14	found	find	VERB
bibechana-74254	57	15	in	in	ADP
bibechana-74254	57	16	hdac1	hdac1	NOUN
bibechana-74254	57	17	[	[	X
bibechana-74254	57	18	27	27	NUM
bibechana-74254	57	19	]	]	PUNCT
bibechana-74254	57	20	,	,	PUNCT
bibechana-74254	57	21	whereas	whereas	SCONJ
bibechana-74254	57	22	a	a	DET
bibechana-74254	57	23	c	c	NOUN
bibechana-74254	57	24	-	-	PUNCT
bibechana-74254	57	25	terminal	terminal	ADJ
bibechana-74254	57	26	coiled	coil	VERB
bibechana-74254	57	27	-	-	PUNCT
bibechana-74254	57	28	coil	coil	NOUN
bibechana-74254	57	29	domain	domain	NOUN
bibechana-74254	57	30	(	(	PUNCT
bibechana-74254	57	31	possibly	possibly	ADV
bibechana-74254	57	32	enabling	enable	VERB
bibechana-74254	57	33	additional	additional	ADJ
bibechana-74254	57	34	protein	protein	NOUN
bibechana-74254	57	35	-	-	PUNCT
bibechana-74254	57	36	protein	protein	NOUN
bibechana-74254	57	37	associations	association	NOUN
bibechana-74254	57	38	)	)	PUNCT
bibechana-74254	57	39	seems	seem	VERB
bibechana-74254	57	40	to	to	PART
bibechana-74254	57	41	be	be	AUX
bibechana-74254	57	42	specific	specific	ADJ
bibechana-74254	57	43	for	for	ADP
bibechana-74254	57	44	hdac2	hdac2	NOUN
bibechana-74254	58	1	[	[	X
bibechana-74254	58	2	6	6	NUM
bibechana-74254	58	3	]	]	PUNCT
bibechana-74254	58	4	.	.	PUNCT
bibechana-74254	59	1	despite	despite	SCONJ
bibechana-74254	59	2	previous	previous	ADJ
bibechana-74254	59	3	research	research	NOUN
bibechana-74254	59	4	into	into	ADP
bibechana-74254	59	5	interactions	interaction	NOUN
bibechana-74254	59	6	between	between	ADP
bibechana-74254	59	7	hdac2	hdac2	NOUN
bibechana-74254	59	8	and	and	CCONJ
bibechana-74254	59	9	mta1	mta1	NOUN
bibechana-74254	59	10	[	[	X
bibechana-74254	59	11	25	25	NUM
bibechana-74254	59	12	]	]	PUNCT
bibechana-74254	59	13	,	,	PUNCT
bibechana-74254	59	14	the	the	DET
bibechana-74254	59	15	precise	precise	ADJ
bibechana-74254	59	16	nature	nature	NOUN
bibechana-74254	59	17	of	of	ADP
bibechana-74254	59	18	the	the	DET
bibechana-74254	59	19	hdac2	hdac2	NOUN
bibechana-74254	59	20	-	-	PUNCT
bibechana-74254	59	21	mta1	mta1	NOUN
bibechana-74254	59	22	functional	functional	ADJ
bibechana-74254	59	23	complex	complex	NOUN
bibechana-74254	59	24	remains	remain	VERB
bibechana-74254	59	25	unknown	unknown	ADJ
bibechana-74254	59	26	.	.	PUNCT
bibechana-74254	60	1	we	we	PRON
bibechana-74254	60	2	used	use	VERB
bibechana-74254	60	3	all	all	DET
bibechana-74254	60	4	-	-	PUNCT
bibechana-74254	60	5	atom	atom	NOUN
bibechana-74254	60	6	molecular	molecular	ADJ
bibechana-74254	60	7	dynamics	dynamic	NOUN
bibechana-74254	60	8	(	(	PUNCT
bibechana-74254	60	9	md	md	NOUN
bibechana-74254	60	10	)	)	PUNCT
bibechana-74254	60	11	simulations	simulation	NOUN
bibechana-74254	60	12	to	to	PART
bibechana-74254	60	13	investigate	investigate	VERB
bibechana-74254	60	14	the	the	DET
bibechana-74254	60	15	interactions	interaction	NOUN
bibechana-74254	60	16	of	of	ADP
bibechana-74254	60	17	hdac2	hdac2	NOUN
bibechana-74254	60	18	and	and	CCONJ
bibechana-74254	60	19	mta1	mta1	PROPN
bibechana-74254	60	20	.	.	PUNCT
bibechana-74254	61	1	md	md	PROPN
bibechana-74254	61	2	simulations	simulation	NOUN
bibechana-74254	61	3	and	and	CCONJ
bibechana-74254	61	4	in	in	ADP
bibechana-74254	61	5	silico	silico	NOUN
bibechana-74254	61	6	studies	study	NOUN
bibechana-74254	61	7	have	have	AUX
bibechana-74254	61	8	successfully	successfully	ADV
bibechana-74254	61	9	been	be	AUX
bibechana-74254	61	10	used	use	VERB
bibechana-74254	61	11	to	to	PART
bibechana-74254	61	12	investigate	investigate	VERB
bibechana-74254	61	13	the	the	DET
bibechana-74254	61	14	molecular	molecular	ADJ
bibechana-74254	61	15	interactions	interaction	NOUN
bibechana-74254	61	16	,	,	PUNCT
bibechana-74254	61	17	including	include	VERB
bibechana-74254	61	18	hdacs	hdac	NOUN
bibechana-74254	61	19	[	[	X
bibechana-74254	61	20	28	28	NUM
bibechana-74254	61	21	,	,	PUNCT
bibechana-74254	61	22	29	29	NUM
bibechana-74254	61	23	]	]	PUNCT
bibechana-74254	61	24	.	.	PUNCT
bibechana-74254	62	1	first	first	ADV
bibechana-74254	62	2	,	,	PUNCT
bibechana-74254	62	3	we	we	PRON
bibechana-74254	62	4	predicted	predict	VERB
bibechana-74254	62	5	the	the	DET
bibechana-74254	62	6	structure	structure	NOUN
bibechana-74254	62	7	of	of	ADP
bibechana-74254	62	8	the	the	DET
bibechana-74254	62	9	hdac2	hdac2	NOUN
bibechana-74254	62	10	-	-	PUNCT
bibechana-74254	62	11	mta1	mta1	NOUN
bibechana-74254	62	12	complex	complex	NOUN
bibechana-74254	62	13	and	and	CCONJ
bibechana-74254	62	14	performed	perform	VERB
bibechana-74254	62	15	md	md	PROPN
bibechana-74254	62	16	simulations	simulation	NOUN
bibechana-74254	62	17	to	to	PART
bibechana-74254	62	18	investigate	investigate	VERB
bibechana-74254	62	19	the	the	DET
bibechana-74254	62	20	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	62	21	interactions	interaction	NOUN
bibechana-74254	62	22	.	.	PUNCT
bibechana-74254	63	1	we	we	PRON
bibechana-74254	63	2	identified	identify	VERB
bibechana-74254	63	3	the	the	DET
bibechana-74254	63	4	binding	bind	VERB
bibechana-74254	63	5	sites	site	NOUN
bibechana-74254	63	6	and	and	CCONJ
bibechana-74254	63	7	crucial	crucial	ADJ
bibechana-74254	63	8	residues	residue	NOUN
bibechana-74254	63	9	and	and	CCONJ
bibechana-74254	63	10	estimated	estimate	VERB
bibechana-74254	63	11	the	the	DET
bibechana-74254	63	12	key	key	ADJ
bibechana-74254	63	13	parameters	parameter	NOUN
bibechana-74254	63	14	related	relate	VERB
bibechana-74254	63	15	to	to	ADP
bibechana-74254	63	16	the	the	DET
bibechana-74254	63	17	structural	structural	ADJ
bibechana-74254	63	18	stability	stability	NOUN
bibechana-74254	63	19	and	and	CCONJ
bibechana-74254	63	20	binding	bind	VERB
bibechana-74254	63	21	affinity	affinity	NOUN
bibechana-74254	63	22	of	of	ADP
bibechana-74254	63	23	the	the	DET
bibechana-74254	63	24	complex	complex	NOUN
bibechana-74254	63	25	.	.	PUNCT
bibechana-74254	64	1	2	2	NUM
bibechana-74254	64	2	methods	method	NOUN
bibechana-74254	64	3	2.1	2.1	NUM
bibechana-74254	64	4	system	system	NOUN
bibechana-74254	64	5	preparation	preparation	NOUN
bibechana-74254	64	6	the	the	DET
bibechana-74254	64	7	structure	structure	NOUN
bibechana-74254	64	8	of	of	ADP
bibechana-74254	64	9	the	the	DET
bibechana-74254	64	10	hdac2	hdac2	NOUN
bibechana-74254	64	11	-	-	PUNCT
bibechana-74254	64	12	mta1	mta1	PROPN
bibechana-74254	64	13	complex	complex	NOUN
bibechana-74254	64	14	was	be	AUX
bibechana-74254	64	15	predicted	predict	VERB
bibechana-74254	64	16	with	with	ADP
bibechana-74254	64	17	alphafold2	alphafold2	NOUN
bibechana-74254	64	18	colab	colab	NOUN
bibechana-74254	65	1	[	[	X
bibechana-74254	65	2	30	30	NUM
bibechana-74254	65	3	]	]	PUNCT
bibechana-74254	65	4	using	use	VERB
bibechana-74254	65	5	the	the	DET
bibechana-74254	65	6	fasta	fasta	PROPN
bibechana-74254	65	7	sequences	sequence	NOUN
bibechana-74254	65	8	of	of	ADP
bibechana-74254	65	9	hdac2	hdac2	NOUN
bibechana-74254	65	10	(	(	PUNCT
bibechana-74254	65	11	uniprot	uniprot	ADJ
bibechana-74254	65	12	[	[	X
bibechana-74254	65	13	31	31	NUM
bibechana-74254	65	14	]	]	PUNCT
bibechana-74254	65	15	accession	accession	NOUN
bibechana-74254	65	16	i	i	PROPN
bibechana-74254	65	17	d	d	PROPN
bibechana-74254	65	18	q92769	q92769	PROPN
bibechana-74254	65	19	)	)	PUNCT
bibechana-74254	65	20	and	and	CCONJ
bibechana-74254	65	21	mta1	mta1	PROPN
bibechana-74254	65	22	(	(	PUNCT
bibechana-74254	65	23	uniprot	uniprot	ADJ
bibechana-74254	65	24	[	[	X
bibechana-74254	65	25	31	31	NUM
bibechana-74254	65	26	]	]	PUNCT
bibechana-74254	65	27	accession	accession	NOUN
bibechana-74254	65	28	i	i	PROPN
bibechana-74254	65	29	d	d	PROPN
bibechana-74254	65	30	q13330	q13330	PROPN
bibechana-74254	65	31	)	)	PUNCT
bibechana-74254	65	32	.	.	PUNCT
bibechana-74254	66	1	hdac2	hdac2	NOUN
bibechana-74254	66	2	and	and	CCONJ
bibechana-74254	66	3	mta1	mta1	NOUN
bibechana-74254	66	4	proteins	protein	NOUN
bibechana-74254	66	5	have	have	VERB
bibechana-74254	66	6	488	488	NUM
bibechana-74254	66	7	and	and	CCONJ
bibechana-74254	66	8	715	715	NUM
bibechana-74254	66	9	amino	amino	NOUN
bibechana-74254	66	10	acids	acid	NOUN
bibechana-74254	66	11	,	,	PUNCT
bibechana-74254	66	12	respectively	respectively	ADV
bibechana-74254	66	13	.	.	PUNCT
bibechana-74254	67	1	the	the	DET
bibechana-74254	67	2	alphafold2	alphafold2	ADJ
bibechana-74254	67	3	prediction	prediction	NOUN
bibechana-74254	67	4	of	of	ADP
bibechana-74254	67	5	the	the	DET
bibechana-74254	67	6	hdac2	hdac2	NOUN
bibechana-74254	67	7	-	-	PUNCT
bibechana-74254	67	8	mta1	mta1	PROPN
bibechana-74254	67	9	complex	complex	NOUN
bibechana-74254	67	10	was	be	AUX
bibechana-74254	67	11	obtained	obtain	VERB
bibechana-74254	67	12	with	with	ADP
bibechana-74254	67	13	full	full	ADJ
bibechana-74254	67	14	-	-	PUNCT
bibechana-74254	67	15	length	length	NOUN
bibechana-74254	67	16	sequences	sequence	NOUN
bibechana-74254	67	17	for	for	ADP
bibechana-74254	67	18	hdac2	hdac2	NOUN
bibechana-74254	67	19	and	and	CCONJ
bibechana-74254	67	20	mta1	mta1	PROPN
bibechana-74254	67	21	.	.	PUNCT
bibechana-74254	68	1	2.2	2.2	NUM
bibechana-74254	68	2	md	md	PROPN
bibechana-74254	68	3	simulations	simulation	NOUN
bibechana-74254	68	4	we	we	PRON
bibechana-74254	68	5	utilized	utilize	VERB
bibechana-74254	68	6	the	the	DET
bibechana-74254	68	7	namd	namd	ADJ
bibechana-74254	68	8	software	software	NOUN
bibechana-74254	68	9	[	[	X
bibechana-74254	68	10	32	32	NUM
bibechana-74254	68	11	]	]	PUNCT
bibechana-74254	68	12	and	and	CCONJ
bibechana-74254	68	13	the	the	DET
bibechana-74254	68	14	charmm36	charmm36	NOUN
bibechana-74254	68	15	m	m	VERB
bibechana-74254	68	16	force	force	NOUN
bibechana-74254	68	17	field	field	NOUN
bibechana-74254	69	1	[	[	X
bibechana-74254	69	2	33	33	NUM
bibechana-74254	69	3	]	]	PUNCT
bibechana-74254	69	4	to	to	PART
bibechana-74254	69	5	conduct	conduct	VERB
bibechana-74254	69	6	all	all	DET
bibechana-74254	69	7	-	-	PUNCT
bibechana-74254	69	8	atom	atom	NOUN
bibechana-74254	69	9	md	md	PROPN
bibechana-74254	69	10	simulations	simulation	NOUN
bibechana-74254	69	11	of	of	ADP
bibechana-74254	69	12	the	the	DET
bibechana-74254	69	13	hdac2	hdac2	NOUN
bibechana-74254	69	14	-	-	PUNCT
bibechana-74254	69	15	mta1	mta1	NOUN
bibechana-74254	69	16	complexes	complex	NOUN
bibechana-74254	69	17	,	,	PUNCT
bibechana-74254	69	18	as	as	SCONJ
bibechana-74254	69	19	employed	employ	VERB
bibechana-74254	69	20	in	in	ADP
bibechana-74254	69	21	previous	previous	ADJ
bibechana-74254	69	22	studies	study	NOUN
bibechana-74254	69	23	[	[	X
bibechana-74254	69	24	28	28	NUM
bibechana-74254	69	25	,	,	PUNCT
bibechana-74254	69	26	29	29	NUM
bibechana-74254	69	27	,	,	PUNCT
bibechana-74254	69	28	34	34	NUM
bibechana-74254	69	29	]	]	PUNCT
bibechana-74254	69	30	.	.	PUNCT
bibechana-74254	70	1	the	the	DET
bibechana-74254	70	2	simulation	simulation	NOUN
bibechana-74254	70	3	input	input	NOUN
bibechana-74254	70	4	files	file	NOUN
bibechana-74254	70	5	were	be	AUX
bibechana-74254	70	6	prepared	prepare	VERB
bibechana-74254	70	7	using	use	VERB
bibechana-74254	70	8	the	the	DET
bibechana-74254	70	9	charmm	charmm	NOUN
bibechana-74254	70	10	-	-	PUNCT
bibechana-74254	70	11	gui	gui	NOUN
bibechana-74254	70	12	web	web	NOUN
bibechana-74254	70	13	server	server	NOUN
bibechana-74254	70	14	[	[	X
bibechana-74254	70	15	35	35	NUM
bibechana-74254	70	16	]	]	PUNCT
bibechana-74254	70	17	.	.	PUNCT
bibechana-74254	71	1	in	in	ADP
bibechana-74254	71	2	cubic	cubic	ADJ
bibechana-74254	71	3	boxes	box	NOUN
bibechana-74254	71	4	,	,	PUNCT
bibechana-74254	71	5	the	the	DET
bibechana-74254	71	6	systems	system	NOUN
bibechana-74254	71	7	were	be	AUX
bibechana-74254	71	8	solvated	solvate	VERB
bibechana-74254	71	9	with	with	ADP
bibechana-74254	71	10	a	a	DET
bibechana-74254	71	11	tip3	tip3	NOUN
bibechana-74254	71	12	water	water	NOUN
bibechana-74254	71	13	model	model	NOUN
bibechana-74254	71	14	and	and	CCONJ
bibechana-74254	71	15	150	150	NUM
bibechana-74254	71	16	mm	mm	NOUN
bibechana-74254	71	17	nacl	nacl	NOUN
bibechana-74254	71	18	.	.	PUNCT
bibechana-74254	72	1	the	the	DET
bibechana-74254	72	2	hdac2	hdac2	NOUN
bibechana-74254	72	3	-	-	PUNCT
bibechana-74254	72	4	mta1	mta1	PROPN
bibechana-74254	72	5	complex	complex	NOUN
bibechana-74254	72	6	,	,	PUNCT
bibechana-74254	72	7	after	after	ADP
bibechana-74254	72	8	being	be	AUX
bibechana-74254	72	9	solvated	solvate	VERB
bibechana-74254	72	10	and	and	CCONJ
bibechana-74254	72	11	ion	ion	NOUN
bibechana-74254	72	12	-	-	PUNCT
bibechana-74254	72	13	neutralized	neutralize	VERB
bibechana-74254	72	14	,	,	PUNCT
bibechana-74254	72	15	contained	contain	VERB
bibechana-74254	72	16	a	a	DET
bibechana-74254	72	17	total	total	NOUN
bibechana-74254	72	18	of	of	ADP
bibechana-74254	72	19	139681	139681	NUM
bibechana-74254	72	20	atoms	atom	NOUN
bibechana-74254	72	21	.	.	PUNCT
bibechana-74254	73	1	the	the	DET
bibechana-74254	73	2	system	system	NOUN
bibechana-74254	73	3	was	be	AUX
bibechana-74254	73	4	minimized	minimize	VERB
bibechana-74254	73	5	for	for	ADP
bibechana-74254	73	6	10,000	10,000	NUM
bibechana-74254	73	7	steps	step	NOUN
bibechana-74254	73	8	with	with	ADP
bibechana-74254	73	9	heavy	heavy	ADJ
bibechana-74254	73	10	atoms	atom	NOUN
bibechana-74254	73	11	being	be	AUX
bibechana-74254	73	12	harmonically	harmonically	ADV
bibechana-74254	73	13	restrained	restrain	VERB
bibechana-74254	73	14	,	,	PUNCT
bibechana-74254	73	15	followed	follow	VERB
bibechana-74254	73	16	by	by	ADP
bibechana-74254	73	17	an	an	DET
bibechana-74254	73	18	equilibration	equilibration	NOUN
bibechana-74254	73	19	of	of	ADP
bibechana-74254	73	20	100	100	NUM
bibechana-74254	73	21	narayan	narayan	ADJ
bibechana-74254	73	22	gautam	gautam	PROPN
bibechana-74254	73	23	and	and	CCONJ
bibechana-74254	73	24	narayan	narayan	PROPN
bibechana-74254	73	25	p.	p.	NOUN
bibechana-74254	73	26	adhikari/	adhikari/	NUM
bibechana-74254	73	27	bibechana	bibechana	NOUN
bibechana-74254	73	28	22	22	NUM
bibechana-74254	73	29	(	(	PUNCT
bibechana-74254	73	30	2025	2025	NUM
bibechana-74254	73	31	)	)	PUNCT
bibechana-74254	73	32	108	108	NUM
bibechana-74254	73	33	-	-	SYM
bibechana-74254	73	34	115	115	NUM
bibechana-74254	73	35	110	110	NUM
bibechana-74254	73	36	picoseconds	picosecond	NOUN
bibechana-74254	73	37	using	use	VERB
bibechana-74254	73	38	the	the	DET
bibechana-74254	73	39	nvt	nvt	PROPN
bibechana-74254	73	40	ensemble	ensemble	ADJ
bibechana-74254	73	41	.	.	PUNCT
bibechana-74254	74	1	the	the	DET
bibechana-74254	74	2	production	production	NOUN
bibechana-74254	74	3	runs	run	NOUN
bibechana-74254	74	4	were	be	AUX
bibechana-74254	74	5	performed	perform	VERB
bibechana-74254	74	6	using	use	VERB
bibechana-74254	74	7	a	a	DET
bibechana-74254	74	8	time	time	NOUN
bibechana-74254	74	9	step	step	NOUN
bibechana-74254	74	10	of	of	ADP
bibechana-74254	74	11	2	2	NUM
bibechana-74254	74	12	femtoseconds	femtosecond	NOUN
bibechana-74254	74	13	.	.	PUNCT
bibechana-74254	75	1	2.3	2.3	NUM
bibechana-74254	75	2	data	datum	NOUN
bibechana-74254	75	3	analysis	analysis	NOUN
bibechana-74254	75	4	the	the	DET
bibechana-74254	75	5	vmd	vmd	PROPN
bibechana-74254	75	6	software	software	NOUN
bibechana-74254	76	1	[	[	X
bibechana-74254	76	2	36	36	NUM
bibechana-74254	76	3	]	]	PUNCT
bibechana-74254	76	4	was	be	AUX
bibechana-74254	76	5	utilized	utilize	VERB
bibechana-74254	76	6	to	to	PART
bibechana-74254	76	7	analyze	analyze	VERB
bibechana-74254	76	8	simulation	simulation	NOUN
bibechana-74254	76	9	trajectories	trajectory	NOUN
bibechana-74254	76	10	.	.	PUNCT
bibechana-74254	77	1	chimerax	chimerax	VERB
bibechana-74254	78	1	[	[	X
bibechana-74254	78	2	37	37	NUM
bibechana-74254	78	3	]	]	PUNCT
bibechana-74254	78	4	and	and	CCONJ
bibechana-74254	78	5	vmd	vmd	PROPN
bibechana-74254	78	6	were	be	AUX
bibechana-74254	78	7	utilized	utilize	VERB
bibechana-74254	78	8	to	to	PART
bibechana-74254	78	9	effectively	effectively	ADV
bibechana-74254	78	10	visualize	visualize	VERB
bibechana-74254	78	11	protein	protein	NOUN
bibechana-74254	78	12	structures	structure	NOUN
bibechana-74254	78	13	and	and	CCONJ
bibechana-74254	78	14	generate	generate	VERB
bibechana-74254	78	15	high	high	ADJ
bibechana-74254	78	16	-	-	PUNCT
bibechana-74254	78	17	quality	quality	NOUN
bibechana-74254	78	18	figures	figure	NOUN
bibechana-74254	78	19	.	.	PUNCT
bibechana-74254	79	1	the	the	DET
bibechana-74254	79	2	binding	bind	VERB
bibechana-74254	79	3	free	free	ADJ
bibechana-74254	79	4	energy	energy	NOUN
bibechana-74254	79	5	was	be	AUX
bibechana-74254	79	6	calculated	calculate	VERB
bibechana-74254	79	7	using	use	VERB
bibechana-74254	79	8	the	the	DET
bibechana-74254	79	9	mm	mm	PROPN
bibechana-74254	79	10	/	/	SYM
bibechana-74254	79	11	gbsa	gbsa	ADJ
bibechana-74254	79	12	approach	approach	NOUN
bibechana-74254	79	13	with	with	ADP
bibechana-74254	79	14	namd	namd	NOUN
bibechana-74254	79	15	,	,	PUNCT
bibechana-74254	79	16	as	as	SCONJ
bibechana-74254	79	17	described	describe	VERB
bibechana-74254	79	18	in	in	ADP
bibechana-74254	79	19	previous	previous	ADJ
bibechana-74254	79	20	publications	publication	NOUN
bibechana-74254	80	1	[	[	X
bibechana-74254	80	2	28,29,34	28,29,34	NUM
bibechana-74254	80	3	]	]	PUNCT
bibechana-74254	80	4	.	.	PUNCT
bibechana-74254	81	1	the	the	DET
bibechana-74254	81	2	equation	equation	NOUN
bibechana-74254	81	3	used	use	VERB
bibechana-74254	81	4	to	to	PART
bibechana-74254	81	5	estimate	estimate	VERB
bibechana-74254	81	6	binding	bind	VERB
bibechana-74254	81	7	free	free	ADJ
bibechana-74254	81	8	energy	energy	NOUN
bibechana-74254	81	9	for	for	ADP
bibechana-74254	81	10	the	the	DET
bibechana-74254	81	11	complex	complex	NOUN
bibechana-74254	81	12	is	be	AUX
bibechana-74254	81	13	as	as	SCONJ
bibechana-74254	81	14	followed	follow	VERB
bibechana-74254	81	15	with	with	ADP
bibechana-74254	81	16	the	the	DET
bibechana-74254	81	17	entropy	entropy	NOUN
bibechana-74254	81	18	term	term	NOUN
bibechana-74254	81	19	ignored	ignore	VERB
bibechana-74254	81	20	[	[	PUNCT
bibechana-74254	81	21	38	38	NUM
bibechana-74254	81	22	]	]	PUNCT
bibechana-74254	81	23	:	:	PUNCT
bibechana-74254	81	24	∆g	∆g	PROPN
bibechana-74254	81	25	=	=	SYM
bibechana-74254	81	26	ghdac2−mta1	ghdac2−mta1	NOUN
bibechana-74254	81	27	−ghdac2	−ghdac2	PROPN
bibechana-74254	81	28	−gmta1	−gmta1	NUM
bibechana-74254	81	29	(	(	PUNCT
bibechana-74254	81	30	1	1	NUM
bibechana-74254	81	31	)	)	PUNCT
bibechana-74254	81	32	where	where	SCONJ
bibechana-74254	81	33	,	,	PUNCT
bibechana-74254	81	34	ghdac2−mta1	ghdac2−mta1	NOUN
bibechana-74254	81	35	or	or	CCONJ
bibechana-74254	81	36	ghdac2	ghdac2	NOUN
bibechana-74254	81	37	or	or	CCONJ
bibechana-74254	81	38	gmta1	gmta1	NOUN
bibechana-74254	81	39	is	be	AUX
bibechana-74254	81	40	the	the	DET
bibechana-74254	81	41	sum	sum	NOUN
bibechana-74254	81	42	of	of	ADP
bibechana-74254	81	43	energy	energy	NOUN
bibechana-74254	81	44	contributions	contribution	NOUN
bibechana-74254	81	45	due	due	ADJ
bibechana-74254	81	46	to	to	ADP
bibechana-74254	81	47	internal	internal	ADJ
bibechana-74254	81	48	(	(	PUNCT
bibechana-74254	81	49	bond	bond	NOUN
bibechana-74254	81	50	,	,	PUNCT
bibechana-74254	81	51	angle	angle	NOUN
bibechana-74254	81	52	,	,	PUNCT
bibechana-74254	81	53	dihedral	dihedral	ADJ
bibechana-74254	81	54	,	,	PUNCT
bibechana-74254	81	55	and	and	CCONJ
bibechana-74254	81	56	improper	improper	ADJ
bibechana-74254	81	57	)	)	PUNCT
bibechana-74254	81	58	,	,	PUNCT
bibechana-74254	81	59	electrostatic	electrostatic	ADJ
bibechana-74254	81	60	,	,	PUNCT
bibechana-74254	81	61	van	van	PROPN
bibechana-74254	81	62	der	der	NOUN
bibechana-74254	81	63	waals	waal	NOUN
bibechana-74254	81	64	,	,	PUNCT
bibechana-74254	81	65	and	and	CCONJ
bibechana-74254	81	66	solvation	solvation	NOUN
bibechana-74254	81	67	(	(	PUNCT
bibechana-74254	81	68	polar	polar	ADJ
bibechana-74254	81	69	and	and	CCONJ
bibechana-74254	81	70	non	non	ADJ
bibechana-74254	81	71	-	-	ADJ
bibechana-74254	81	72	polar	polar	ADJ
bibechana-74254	81	73	contributions	contribution	NOUN
bibechana-74254	81	74	)	)	PUNCT
bibechana-74254	81	75	energies	energy	NOUN
bibechana-74254	81	76	(	(	PUNCT
bibechana-74254	81	77	g	g	NOUN
bibechana-74254	81	78	=	=	PUNCT
bibechana-74254	81	79	einternal	einternal	ADJ
bibechana-74254	81	80	+	+	CCONJ
bibechana-74254	81	81	eelectrostatic	eelectrostatic	ADJ
bibechana-74254	81	82	+	+	CCONJ
bibechana-74254	81	83	evdw	evdw	NOUN
bibechana-74254	81	84	+	+	CCONJ
bibechana-74254	81	85	esolvation	esolvation	NOUN
bibechana-74254	81	86	)	)	PUNCT
bibechana-74254	81	87	.	.	PUNCT
bibechana-74254	82	1	a	a	DET
bibechana-74254	82	2	contact	contact	NOUN
bibechana-74254	82	3	distance	distance	NOUN
bibechana-74254	82	4	cutoff	cutoff	NOUN
bibechana-74254	82	5	of	of	ADP
bibechana-74254	82	6	3.5	3.5	NUM
bibechana-74254	82	7	å	å	NOUN
bibechana-74254	82	8	and	and	CCONJ
bibechana-74254	82	9	an	an	DET
bibechana-74254	82	10	angle	angle	NOUN
bibechana-74254	82	11	cutoff	cutoff	NOUN
bibechana-74254	82	12	of	of	ADP
bibechana-74254	82	13	30	30	NUM
bibechana-74254	82	14	degrees	degree	NOUN
bibechana-74254	82	15	were	be	AUX
bibechana-74254	82	16	used	use	VERB
bibechana-74254	82	17	to	to	PART
bibechana-74254	82	18	analyze	analyze	VERB
bibechana-74254	82	19	hydrogen	hydrogen	NOUN
bibechana-74254	82	20	bonding	bonding	NOUN
bibechana-74254	82	21	,	,	PUNCT
bibechana-74254	82	22	and	and	CCONJ
bibechana-74254	82	23	the	the	DET
bibechana-74254	82	24	same	same	ADJ
bibechana-74254	82	25	atomic	atomic	ADJ
bibechana-74254	82	26	distance	distance	NOUN
bibechana-74254	82	27	cutoff	cutoff	NOUN
bibechana-74254	82	28	was	be	AUX
bibechana-74254	82	29	used	use	VERB
bibechana-74254	82	30	to	to	PART
bibechana-74254	82	31	analyze	analyze	VERB
bibechana-74254	82	32	salt	salt	NOUN
bibechana-74254	82	33	bridges	bridge	NOUN
bibechana-74254	82	34	.	.	PUNCT
bibechana-74254	83	1	contact	contact	NOUN
bibechana-74254	83	2	surface	surface	NOUN
bibechana-74254	83	3	area	area	NOUN
bibechana-74254	83	4	was	be	AUX
bibechana-74254	83	5	calculated	calculate	VERB
bibechana-74254	83	6	using	use	VERB
bibechana-74254	83	7	the	the	DET
bibechana-74254	83	8	formula	formula	NOUN
bibechana-74254	83	9	[	[	X
bibechana-74254	83	10	39	39	NUM
bibechana-74254	83	11	]	]	SYM
bibechana-74254	83	12	:	:	PUNCT
bibechana-74254	84	1	contactarea	contactarea	PROPN
bibechana-74254	84	2	=	=	PUNCT
bibechana-74254	84	3	sasahdac2	sasahdac2	NOUN
bibechana-74254	85	1	+	+	CCONJ
bibechana-74254	85	2	sasamta1	sasamta1	NOUN
bibechana-74254	85	3	−	−	ADP
bibechana-74254	85	4	sasahdac2−mta1	sasahdac2−mta1	NOUN
bibechana-74254	85	5	2	2	NUM
bibechana-74254	85	6	(	(	PUNCT
bibechana-74254	85	7	2	2	NUM
bibechana-74254	85	8	)	)	PUNCT
bibechana-74254	85	9	where	where	SCONJ
bibechana-74254	85	10	,	,	PUNCT
bibechana-74254	85	11	sasahdac2	sasahdac2	PROPN
bibechana-74254	85	12	corresponds	correspond	VERB
bibechana-74254	85	13	to	to	ADP
bibechana-74254	85	14	solventaccessible	solventaccessible	ADJ
bibechana-74254	85	15	surface	surface	NOUN
bibechana-74254	85	16	area	area	NOUN
bibechana-74254	85	17	(	(	PUNCT
bibechana-74254	85	18	sasa	sasa	PROPN
bibechana-74254	85	19	)	)	PUNCT
bibechana-74254	85	20	of	of	ADP
bibechana-74254	85	21	hdac2	hdac2	NOUN
bibechana-74254	85	22	at	at	ADP
bibechana-74254	85	23	any	any	DET
bibechana-74254	85	24	time	time	NOUN
bibechana-74254	85	25	,	,	PUNCT
bibechana-74254	85	26	sasamta1	sasamta1	NOUN
bibechana-74254	85	27	to	to	PART
bibechana-74254	85	28	sasa	sasa	NOUN
bibechana-74254	85	29	of	of	ADP
bibechana-74254	85	30	mta1	mta1	PROPN
bibechana-74254	85	31	,	,	PUNCT
bibechana-74254	85	32	and	and	CCONJ
bibechana-74254	85	33	sasahdac2−mta1	sasahdac2−mta1	NOUN
bibechana-74254	85	34	to	to	ADP
bibechana-74254	85	35	sasa	sasa	NOUN
bibechana-74254	85	36	of	of	ADP
bibechana-74254	85	37	the	the	DET
bibechana-74254	85	38	complex	complex	NOUN
bibechana-74254	85	39	.	.	PUNCT
bibechana-74254	86	1	vmd	vmd	PROPN
bibechana-74254	86	2	was	be	AUX
bibechana-74254	86	3	used	use	VERB
bibechana-74254	86	4	to	to	PART
bibechana-74254	86	5	measure	measure	VERB
bibechana-74254	86	6	the	the	DET
bibechana-74254	86	7	sasa	sasa	PROPN
bibechana-74254	86	8	values	value	NOUN
bibechana-74254	86	9	using	use	VERB
bibechana-74254	86	10	the	the	DET
bibechana-74254	86	11	simulation	simulation	NOUN
bibechana-74254	86	12	trajectories	trajectory	NOUN
bibechana-74254	86	13	.	.	PUNCT
bibechana-74254	87	1	3	3	NUM
bibechana-74254	87	2	results	result	NOUN
bibechana-74254	87	3	and	and	CCONJ
bibechana-74254	87	4	discussion	discussion	NOUN
bibechana-74254	87	5	we	we	PRON
bibechana-74254	87	6	used	use	VERB
bibechana-74254	87	7	alphafold2	alphafold2	NOUN
bibechana-74254	87	8	to	to	PART
bibechana-74254	87	9	predict	predict	VERB
bibechana-74254	87	10	the	the	DET
bibechana-74254	87	11	molecular	molecular	ADJ
bibechana-74254	87	12	structure	structure	NOUN
bibechana-74254	87	13	of	of	ADP
bibechana-74254	87	14	the	the	DET
bibechana-74254	87	15	hdac2	hdac2	NOUN
bibechana-74254	87	16	-	-	PUNCT
bibechana-74254	87	17	mta1	mta1	NOUN
bibechana-74254	87	18	complex	complex	NOUN
bibechana-74254	87	19	and	and	CCONJ
bibechana-74254	87	20	performed	perform	VERB
bibechana-74254	87	21	md	md	PROPN
bibechana-74254	87	22	simulations	simulation	NOUN
bibechana-74254	87	23	to	to	PART
bibechana-74254	87	24	study	study	VERB
bibechana-74254	87	25	into	into	ADP
bibechana-74254	87	26	how	how	SCONJ
bibechana-74254	87	27	the	the	DET
bibechana-74254	87	28	complex	complex	NOUN
bibechana-74254	87	29	formed	form	VERB
bibechana-74254	87	30	between	between	ADP
bibechana-74254	87	31	hdac2	hdac2	NOUN
bibechana-74254	87	32	and	and	CCONJ
bibechana-74254	87	33	the	the	DET
bibechana-74254	87	34	mta1	mta1	NOUN
bibechana-74254	87	35	protein	protein	NOUN
bibechana-74254	87	36	.	.	PUNCT
bibechana-74254	88	1	to	to	PART
bibechana-74254	88	2	evaluate	evaluate	VERB
bibechana-74254	88	3	the	the	DET
bibechana-74254	88	4	structural	structural	ADJ
bibechana-74254	88	5	stability	stability	NOUN
bibechana-74254	88	6	of	of	ADP
bibechana-74254	88	7	the	the	DET
bibechana-74254	88	8	predicted	predict	VERB
bibechana-74254	88	9	complex	complex	NOUN
bibechana-74254	88	10	and	and	CCONJ
bibechana-74254	88	11	identify	identify	VERB
bibechana-74254	88	12	the	the	DET
bibechana-74254	88	13	crucial	crucial	ADJ
bibechana-74254	88	14	residues	residue	NOUN
bibechana-74254	88	15	that	that	PRON
bibechana-74254	88	16	contribute	contribute	VERB
bibechana-74254	88	17	to	to	ADP
bibechana-74254	88	18	the	the	DET
bibechana-74254	88	19	formation	formation	NOUN
bibechana-74254	88	20	,	,	PUNCT
bibechana-74254	88	21	we	we	PRON
bibechana-74254	88	22	performed	perform	VERB
bibechana-74254	88	23	an	an	DET
bibechana-74254	88	24	md	md	PROPN
bibechana-74254	88	25	simulation	simulation	NOUN
bibechana-74254	88	26	.	.	PUNCT
bibechana-74254	89	1	additionally	additionally	ADV
bibechana-74254	89	2	,	,	PUNCT
bibechana-74254	89	3	we	we	PRON
bibechana-74254	89	4	calculated	calculate	VERB
bibechana-74254	89	5	the	the	DET
bibechana-74254	89	6	binding	bind	VERB
bibechana-74254	89	7	free	free	ADJ
bibechana-74254	89	8	energy	energy	NOUN
bibechana-74254	89	9	and	and	CCONJ
bibechana-74254	89	10	contact	contact	NOUN
bibechana-74254	89	11	surface	surface	NOUN
bibechana-74254	89	12	area	area	NOUN
bibechana-74254	89	13	of	of	ADP
bibechana-74254	89	14	the	the	DET
bibechana-74254	89	15	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	89	16	complex	complex	NOUN
bibechana-74254	89	17	.	.	PUNCT
bibechana-74254	89	18	3.1	3.1	NUM
bibechana-74254	89	19	prediction	prediction	NOUN
bibechana-74254	89	20	of	of	ADP
bibechana-74254	89	21	the	the	DET
bibechana-74254	89	22	hdac2	hdac2	NOUN
bibechana-74254	89	23	-	-	PUNCT
bibechana-74254	89	24	mta1	mta1	PROPN
bibechana-74254	89	25	complex	complex	ADJ
bibechana-74254	89	26	figures	figure	NOUN
bibechana-74254	89	27	1(a	1(a	NUM
bibechana-74254	89	28	)	)	PUNCT
bibechana-74254	89	29	and	and	CCONJ
bibechana-74254	89	30	1(b	1(b	NUM
bibechana-74254	89	31	)	)	PUNCT
bibechana-74254	89	32	illustrate	illustrate	VERB
bibechana-74254	89	33	the	the	DET
bibechana-74254	89	34	individual	individual	ADJ
bibechana-74254	89	35	complete	complete	ADJ
bibechana-74254	89	36	structures	structure	NOUN
bibechana-74254	89	37	of	of	ADP
bibechana-74254	89	38	hdac2	hdac2	NOUN
bibechana-74254	89	39	and	and	CCONJ
bibechana-74254	89	40	mta1	mta1	NOUN
bibechana-74254	89	41	proteins	protein	NOUN
bibechana-74254	89	42	predicted	predict	VERB
bibechana-74254	89	43	from	from	ADP
bibechana-74254	89	44	alphafold2	alphafold2	NOUN
bibechana-74254	89	45	respectively	respectively	ADV
bibechana-74254	89	46	.	.	PUNCT
bibechana-74254	90	1	although	although	SCONJ
bibechana-74254	90	2	the	the	DET
bibechana-74254	90	3	mta1	mta1	NOUN
bibechana-74254	90	4	protein	protein	NOUN
bibechana-74254	90	5	exhibits	exhibit	VERB
bibechana-74254	90	6	a	a	DET
bibechana-74254	90	7	highly	highly	ADV
bibechana-74254	90	8	disordered	disordered	ADJ
bibechana-74254	90	9	structure	structure	NOUN
bibechana-74254	90	10	with	with	ADP
bibechana-74254	90	11	unstructured	unstructured	ADJ
bibechana-74254	90	12	loops	loop	NOUN
bibechana-74254	90	13	,	,	PUNCT
bibechana-74254	90	14	hdac2	hdac2	NOUN
bibechana-74254	90	15	has	have	VERB
bibechana-74254	90	16	a	a	DET
bibechana-74254	90	17	more	more	ADV
bibechana-74254	90	18	stable	stable	ADJ
bibechana-74254	90	19	structure	structure	NOUN
bibechana-74254	90	20	.	.	PUNCT
bibechana-74254	91	1	figure	figure	NOUN
bibechana-74254	91	2	1(c	1(c	NUM
bibechana-74254	91	3	)	)	PUNCT
bibechana-74254	91	4	illustrates	illustrate	VERB
bibechana-74254	91	5	the	the	DET
bibechana-74254	91	6	hdac2	hdac2	NOUN
bibechana-74254	91	7	-	-	PUNCT
bibechana-74254	91	8	mta1	mta1	PROPN
bibechana-74254	91	9	complex	complex	ADJ
bibechana-74254	91	10	structures	structure	NOUN
bibechana-74254	91	11	predicted	predict	VERB
bibechana-74254	91	12	by	by	ADP
bibechana-74254	91	13	alphafold2	alphafold2	PROPN
bibechana-74254	91	14	.	.	PUNCT
bibechana-74254	92	1	this	this	PRON
bibechana-74254	92	2	predicted	predict	VERB
bibechana-74254	92	3	model	model	PROPN
bibechana-74254	92	4	’s	’s	PART
bibechana-74254	92	5	interface	interface	NOUN
bibechana-74254	92	6	predicted	predict	VERB
bibechana-74254	92	7	template	template	NOUN
bibechana-74254	92	8	modeling	modeling	NOUN
bibechana-74254	92	9	(	(	PUNCT
bibechana-74254	92	10	iptm	iptm	NOUN
bibechana-74254	92	11	)	)	PUNCT
bibechana-74254	92	12	score	score	NOUN
bibechana-74254	92	13	is	be	AUX
bibechana-74254	92	14	0.76	0.76	NUM
bibechana-74254	92	15	.	.	PUNCT
bibechana-74254	93	1	model	model	NOUN
bibechana-74254	93	2	confidence	confidence	NOUN
bibechana-74254	93	3	is	be	AUX
bibechana-74254	93	4	typically	typically	ADV
bibechana-74254	93	5	associated	associate	VERB
bibechana-74254	93	6	with	with	ADP
bibechana-74254	93	7	an	an	DET
bibechana-74254	93	8	iptm	iptm	ADJ
bibechana-74254	93	9	score	score	NOUN
bibechana-74254	93	10	of	of	ADP
bibechana-74254	93	11	0.75	0.75	NUM
bibechana-74254	93	12	or	or	CCONJ
bibechana-74254	93	13	higher	high	ADJ
bibechana-74254	93	14	[	[	X
bibechana-74254	93	15	40	40	NUM
bibechana-74254	93	16	]	]	PUNCT
bibechana-74254	93	17	.	.	PUNCT
bibechana-74254	94	1	to	to	ADP
bibechana-74254	94	2	the	the	DET
bibechana-74254	94	3	best	good	ADJ
bibechana-74254	94	4	of	of	ADP
bibechana-74254	94	5	our	our	PRON
bibechana-74254	94	6	knowledge	knowledge	NOUN
bibechana-74254	94	7	,	,	PUNCT
bibechana-74254	94	8	the	the	DET
bibechana-74254	94	9	specific	specific	ADJ
bibechana-74254	94	10	hdac2	hdac2	NOUN
bibechana-74254	94	11	amino	amino	NOUN
bibechana-74254	94	12	acids	acid	NOUN
bibechana-74254	94	13	that	that	PRON
bibechana-74254	94	14	interact	interact	VERB
bibechana-74254	94	15	with	with	ADP
bibechana-74254	94	16	mta1	mta1	NOUN
bibechana-74254	94	17	have	have	AUX
bibechana-74254	94	18	not	not	PART
bibechana-74254	94	19	yet	yet	ADV
bibechana-74254	94	20	reported	report	VERB
bibechana-74254	94	21	.	.	PUNCT
bibechana-74254	95	1	we	we	PRON
bibechana-74254	95	2	were	be	AUX
bibechana-74254	95	3	able	able	ADJ
bibechana-74254	95	4	to	to	PART
bibechana-74254	95	5	predict	predict	VERB
bibechana-74254	95	6	the	the	DET
bibechana-74254	95	7	structure	structure	NOUN
bibechana-74254	95	8	of	of	ADP
bibechana-74254	95	9	the	the	DET
bibechana-74254	95	10	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	95	11	complex	complex	NOUN
bibechana-74254	95	12	by	by	ADP
bibechana-74254	95	13	giving	give	VERB
bibechana-74254	95	14	alphafold2	alphafold2	NOUN
bibechana-74254	95	15	a	a	DET
bibechana-74254	95	16	full	full	ADJ
bibechana-74254	95	17	-	-	PUNCT
bibechana-74254	95	18	length	length	NOUN
bibechana-74254	95	19	sequence	sequence	NOUN
bibechana-74254	95	20	of	of	ADP
bibechana-74254	95	21	both	both	DET
bibechana-74254	95	22	hdac2	hdac2	NOUN
bibechana-74254	95	23	and	and	CCONJ
bibechana-74254	95	24	mta1	mta1	PROPN
bibechana-74254	95	25	.	.	PUNCT
bibechana-74254	96	1	the	the	DET
bibechana-74254	96	2	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	96	3	complex	complex	NOUN
bibechana-74254	96	4	included	include	VERB
bibechana-74254	96	5	a	a	DET
bibechana-74254	96	6	full	full	ADJ
bibechana-74254	96	7	-	-	PUNCT
bibechana-74254	96	8	length	length	NOUN
bibechana-74254	96	9	hdac2	hdac2	NOUN
bibechana-74254	96	10	and	and	CCONJ
bibechana-74254	96	11	mta1	mta1	NOUN
bibechana-74254	96	12	sequence	sequence	NOUN
bibechana-74254	96	13	,	,	PUNCT
bibechana-74254	96	14	as	as	SCONJ
bibechana-74254	96	15	illustrated	illustrate	VERB
bibechana-74254	96	16	in	in	ADP
bibechana-74254	96	17	figure	figure	NOUN
bibechana-74254	96	18	1(c	1(c	NUM
bibechana-74254	96	19	)	)	PUNCT
bibechana-74254	96	20	.	.	PUNCT
bibechana-74254	97	1	a	a	DET
bibechana-74254	97	2	robust	robust	ADJ
bibechana-74254	97	3	cutoff	cutoff	NOUN
bibechana-74254	97	4	of	of	ADP
bibechana-74254	97	5	5	5	NUM
bibechana-74254	97	6	å	å	PROPN
bibechana-74254	97	7	is	be	AUX
bibechana-74254	97	8	effective	effective	ADJ
bibechana-74254	97	9	in	in	ADP
bibechana-74254	97	10	establishing	establish	VERB
bibechana-74254	97	11	solid	solid	ADJ
bibechana-74254	97	12	foundations	foundation	NOUN
bibechana-74254	97	13	of	of	ADP
bibechana-74254	97	14	the	the	DET
bibechana-74254	97	15	protein	protein	NOUN
bibechana-74254	97	16	structure	structure	NOUN
bibechana-74254	97	17	networks	network	NOUN
bibechana-74254	97	18	approach	approach	VERB
bibechana-74254	97	19	[	[	X
bibechana-74254	97	20	41	41	NUM
bibechana-74254	97	21	]	]	PUNCT
bibechana-74254	97	22	.	.	PUNCT
bibechana-74254	98	1	the	the	DET
bibechana-74254	98	2	amino	amino	NOUN
bibechana-74254	98	3	acids	acid	NOUN
bibechana-74254	98	4	in	in	ADP
bibechana-74254	98	5	the	the	DET
bibechana-74254	98	6	mta1	mta1	NOUN
bibechana-74254	98	7	protein	protein	NOUN
bibechana-74254	98	8	strongly	strongly	ADV
bibechana-74254	98	9	interact	interact	VERB
bibechana-74254	98	10	with	with	ADP
bibechana-74254	98	11	hdac2	hdac2	NOUN
bibechana-74254	98	12	in	in	ADP
bibechana-74254	98	13	several	several	ADJ
bibechana-74254	98	14	areas	area	NOUN
bibechana-74254	98	15	,	,	PUNCT
bibechana-74254	98	16	including	include	VERB
bibechana-74254	98	17	the	the	DET
bibechana-74254	98	18	helix	helix	NOUN
bibechana-74254	98	19	,	,	PUNCT
bibechana-74254	98	20	the	the	DET
bibechana-74254	98	21	beta	beta	ADJ
bibechana-74254	98	22	sheet	sheet	NOUN
bibechana-74254	98	23	,	,	PUNCT
bibechana-74254	98	24	and	and	CCONJ
bibechana-74254	98	25	the	the	DET
bibechana-74254	98	26	unstructured	unstructured	ADJ
bibechana-74254	98	27	loops	loop	NOUN
bibechana-74254	98	28	.	.	PUNCT
bibechana-74254	99	1	to	to	PART
bibechana-74254	99	2	make	make	VERB
bibechana-74254	99	3	the	the	DET
bibechana-74254	99	4	system	system	NOUN
bibechana-74254	99	5	as	as	ADV
bibechana-74254	99	6	small	small	ADJ
bibechana-74254	99	7	as	as	ADP
bibechana-74254	99	8	possible	possible	ADJ
bibechana-74254	99	9	,	,	PUNCT
bibechana-74254	99	10	we	we	PRON
bibechana-74254	99	11	removed	remove	VERB
bibechana-74254	99	12	unstructured	unstructured	ADJ
bibechana-74254	99	13	loops	loop	NOUN
bibechana-74254	99	14	and	and	CCONJ
bibechana-74254	99	15	helices	helix	NOUN
bibechana-74254	99	16	that	that	PRON
bibechana-74254	99	17	were	be	AUX
bibechana-74254	99	18	away	away	ADV
bibechana-74254	99	19	from	from	ADP
bibechana-74254	99	20	more	more	ADJ
bibechana-74254	99	21	than	than	ADP
bibechana-74254	99	22	5	5	NUM
bibechana-74254	99	23	angstroms	angstrom	NOUN
bibechana-74254	99	24	from	from	ADP
bibechana-74254	99	25	where	where	SCONJ
bibechana-74254	99	26	the	the	DET
bibechana-74254	99	27	hdac2	hdac2	NOUN
bibechana-74254	99	28	and	and	CCONJ
bibechana-74254	99	29	mta1	mta1	NOUN
bibechana-74254	99	30	meets	meet	VERB
bibechana-74254	99	31	as	as	SCONJ
bibechana-74254	99	32	shown	show	VERB
bibechana-74254	99	33	in	in	ADP
bibechana-74254	99	34	figure	figure	NOUN
bibechana-74254	99	35	1(d	1(d	NUM
bibechana-74254	99	36	)	)	PUNCT
bibechana-74254	99	37	.	.	PUNCT
bibechana-74254	100	1	this	this	DET
bibechana-74254	100	2	truncation	truncation	NOUN
bibechana-74254	100	3	significantly	significantly	ADV
bibechana-74254	100	4	reduces	reduce	VERB
bibechana-74254	100	5	the	the	DET
bibechana-74254	100	6	size	size	NOUN
bibechana-74254	100	7	of	of	ADP
bibechana-74254	100	8	the	the	DET
bibechana-74254	100	9	system	system	NOUN
bibechana-74254	100	10	as	as	ADV
bibechana-74254	100	11	well	well	ADV
bibechana-74254	100	12	as	as	ADP
bibechana-74254	100	13	the	the	DET
bibechana-74254	100	14	computational	computational	ADJ
bibechana-74254	100	15	cost	cost	NOUN
bibechana-74254	100	16	.	.	PUNCT
bibechana-74254	101	1	subsequently	subsequently	ADV
bibechana-74254	101	2	,	,	PUNCT
bibechana-74254	101	3	we	we	PRON
bibechana-74254	101	4	performed	perform	VERB
bibechana-74254	101	5	a	a	DET
bibechana-74254	101	6	500	500	NUM
bibechana-74254	101	7	ns	ns	NUM
bibechana-74254	101	8	md	md	PROPN
bibechana-74254	101	9	simulation	simulation	NOUN
bibechana-74254	101	10	of	of	ADP
bibechana-74254	101	11	the	the	DET
bibechana-74254	101	12	complex	complex	NOUN
bibechana-74254	101	13	that	that	PRON
bibechana-74254	101	14	included	include	VERB
bibechana-74254	101	15	all	all	DET
bibechana-74254	101	16	atoms	atom	NOUN
bibechana-74254	101	17	.	.	PUNCT
bibechana-74254	102	1	figure	figure	NOUN
bibechana-74254	102	2	1	1	NUM
bibechana-74254	102	3	:	:	PUNCT
bibechana-74254	102	4	(	(	PUNCT
bibechana-74254	102	5	a	a	X
bibechana-74254	102	6	)	)	PUNCT
bibechana-74254	102	7	structure	structure	NOUN
bibechana-74254	102	8	of	of	ADP
bibechana-74254	102	9	hdac2	hdac2	NOUN
bibechana-74254	102	10	(	(	PUNCT
bibechana-74254	102	11	b	b	NOUN
bibechana-74254	102	12	)	)	PUNCT
bibechana-74254	102	13	structure	structure	NOUN
bibechana-74254	102	14	of	of	ADP
bibechana-74254	102	15	mta1(c	mta1(c	NOUN
bibechana-74254	102	16	)	)	PUNCT
bibechana-74254	102	17	modeled	model	VERB
bibechana-74254	102	18	structure	structure	NOUN
bibechana-74254	102	19	of	of	ADP
bibechana-74254	102	20	hdac2	hdac2	NOUN
bibechana-74254	102	21	-	-	PUNCT
bibechana-74254	102	22	mta1	mta1	NOUN
bibechana-74254	102	23	complex	complex	NOUN
bibechana-74254	102	24	;	;	PUNCT
bibechana-74254	102	25	(	(	PUNCT
bibechana-74254	102	26	d	d	X
bibechana-74254	102	27	)	)	PUNCT
bibechana-74254	102	28	structure	structure	NOUN
bibechana-74254	102	29	of	of	ADP
bibechana-74254	102	30	the	the	DET
bibechana-74254	102	31	hdac2	hdac2	NOUN
bibechana-74254	102	32	-	-	PUNCT
bibechana-74254	102	33	mta1	mta1	PROPN
bibechana-74254	102	34	complex	complex	NOUN
bibechana-74254	102	35	after	after	ADP
bibechana-74254	102	36	removing	remove	VERB
bibechana-74254	102	37	the	the	DET
bibechana-74254	102	38	loops	loop	NOUN
bibechana-74254	102	39	beyond	beyond	ADP
bibechana-74254	102	40	five	five	NUM
bibechana-74254	102	41	angstroms	angstrom	NOUN
bibechana-74254	102	42	form	form	VERB
bibechana-74254	102	43	each	each	DET
bibechana-74254	102	44	other	other	ADJ
bibechana-74254	102	45	.	.	PUNCT
bibechana-74254	103	1	narayan	narayan	PROPN
bibechana-74254	103	2	gautam	gautam	PROPN
bibechana-74254	103	3	and	and	CCONJ
bibechana-74254	103	4	narayan	narayan	PROPN
bibechana-74254	103	5	p.	p.	NOUN
bibechana-74254	103	6	adhikari/	adhikari/	NUM
bibechana-74254	103	7	bibechana	bibechana	NOUN
bibechana-74254	103	8	22	22	NUM
bibechana-74254	103	9	(	(	PUNCT
bibechana-74254	103	10	2025	2025	NUM
bibechana-74254	103	11	)	)	PUNCT
bibechana-74254	103	12	108	108	NUM
bibechana-74254	103	13	-	-	SYM
bibechana-74254	103	14	115	115	NUM
bibechana-74254	103	15	111	111	NUM
bibechana-74254	103	16	3.2	3.2	NUM
bibechana-74254	103	17	structural	structural	ADJ
bibechana-74254	103	18	stability	stability	NOUN
bibechana-74254	103	19	of	of	ADP
bibechana-74254	103	20	the	the	DET
bibechana-74254	103	21	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	103	22	complex	complex	NOUN
bibechana-74254	103	23	we	we	PRON
bibechana-74254	103	24	monitored	monitor	VERB
bibechana-74254	103	25	the	the	DET
bibechana-74254	103	26	structural	structural	ADJ
bibechana-74254	103	27	stability	stability	NOUN
bibechana-74254	103	28	of	of	ADP
bibechana-74254	103	29	the	the	DET
bibechana-74254	103	30	hdac2	hdac2	NOUN
bibechana-74254	103	31	-	-	PUNCT
bibechana-74254	103	32	mta1	mta1	PROPN
bibechana-74254	103	33	complex	complex	NOUN
bibechana-74254	103	34	using	use	VERB
bibechana-74254	103	35	rmsd	rmsd	NOUN
bibechana-74254	103	36	measurements	measurement	NOUN
bibechana-74254	103	37	as	as	SCONJ
bibechana-74254	103	38	shown	show	VERB
bibechana-74254	103	39	in	in	ADP
bibechana-74254	103	40	figure	figure	NOUN
bibechana-74254	103	41	2(a	2(a	NUM
bibechana-74254	103	42	)	)	PUNCT
bibechana-74254	103	43	and	and	CCONJ
bibechana-74254	103	44	used	use	VERB
bibechana-74254	103	45	simulation	simulation	NOUN
bibechana-74254	103	46	results	result	NOUN
bibechana-74254	103	47	to	to	PART
bibechana-74254	103	48	confirm	confirm	VERB
bibechana-74254	103	49	hdac2	hdac2	NOUN
bibechana-74254	103	50	-	-	PUNCT
bibechana-74254	103	51	mta1	mta1	PROPN
bibechana-74254	103	52	complex	complex	ADJ
bibechana-74254	103	53	formation	formation	NOUN
bibechana-74254	103	54	.	.	PUNCT
bibechana-74254	104	1	rmsd	rmsd	PROPN
bibechana-74254	104	2	plot	plot	NOUN
bibechana-74254	104	3	shows	show	VERB
bibechana-74254	104	4	the	the	DET
bibechana-74254	104	5	initial	initial	ADJ
bibechana-74254	104	6	reorganizations	reorganization	NOUN
bibechana-74254	104	7	until	until	ADP
bibechana-74254	104	8	280	280	NUM
bibechana-74254	104	9	ns	ns	NUM
bibechana-74254	104	10	,	,	PUNCT
bibechana-74254	104	11	but	but	CCONJ
bibechana-74254	104	12	after	after	ADP
bibechana-74254	104	13	that	that	PRON
bibechana-74254	104	14	the	the	DET
bibechana-74254	104	15	structural	structural	ADJ
bibechana-74254	104	16	stability	stability	NOUN
bibechana-74254	104	17	of	of	ADP
bibechana-74254	104	18	the	the	DET
bibechana-74254	104	19	complex	complex	NOUN
bibechana-74254	104	20	was	be	AUX
bibechana-74254	104	21	maintained	maintain	VERB
bibechana-74254	104	22	with	with	ADP
bibechana-74254	104	23	relatively	relatively	ADV
bibechana-74254	104	24	stable	stable	ADJ
bibechana-74254	104	25	rmsd	rmsd	NOUN
bibechana-74254	104	26	measurements	measurement	NOUN
bibechana-74254	104	27	.	.	PUNCT
bibechana-74254	105	1	figure	figure	VERB
bibechana-74254	105	2	2(b	2(b	NUM
bibechana-74254	105	3	)	)	PUNCT
bibechana-74254	106	1	shows	show	VERB
bibechana-74254	106	2	the	the	DET
bibechana-74254	106	3	structure	structure	NOUN
bibechana-74254	106	4	of	of	ADP
bibechana-74254	106	5	the	the	DET
bibechana-74254	106	6	complex	complex	NOUN
bibechana-74254	106	7	after	after	ADP
bibechana-74254	106	8	500	500	NUM
bibechana-74254	106	9	ns	ns	NUM
bibechana-74254	106	10	of	of	ADP
bibechana-74254	106	11	simulation	simulation	NOUN
bibechana-74254	106	12	of	of	ADP
bibechana-74254	106	13	the	the	DET
bibechana-74254	106	14	hdac2	hdac2	NOUN
bibechana-74254	106	15	-	-	PUNCT
bibechana-74254	106	16	mta1	mta1	PROPN
bibechana-74254	106	17	.	.	PUNCT
bibechana-74254	107	1	figure	figure	VERB
bibechana-74254	107	2	2	2	NUM
bibechana-74254	107	3	:	:	PUNCT
bibechana-74254	107	4	(	(	PUNCT
bibechana-74254	107	5	a	a	X
bibechana-74254	107	6	)	)	PUNCT
bibechana-74254	107	7	rmsd	rmsd	NOUN
bibechana-74254	107	8	of	of	ADP
bibechana-74254	107	9	the	the	DET
bibechana-74254	107	10	hdac2	hdac2	NOUN
bibechana-74254	107	11	-	-	PUNCT
bibechana-74254	107	12	mta1	mta1	PROPN
bibechana-74254	107	13	complex	complex	NOUN
bibechana-74254	107	14	from	from	ADP
bibechana-74254	107	15	the	the	DET
bibechana-74254	107	16	500	500	NUM
bibechana-74254	107	17	ns	ns	NUM
bibechana-74254	107	18	simulation	simulation	NOUN
bibechana-74254	107	19	trajectory	trajectory	NOUN
bibechana-74254	107	20	.	.	PUNCT
bibechana-74254	108	1	(	(	PUNCT
bibechana-74254	108	2	b	b	NOUN
bibechana-74254	108	3	)	)	PUNCT
bibechana-74254	108	4	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	108	5	complex	complex	ADJ
bibechana-74254	108	6	structure	structure	NOUN
bibechana-74254	108	7	after	after	ADP
bibechana-74254	108	8	500	500	NUM
bibechana-74254	108	9	ns	ns	NUM
bibechana-74254	108	10	of	of	ADP
bibechana-74254	108	11	simulation	simulation	NOUN
bibechana-74254	108	12	time	time	NOUN
bibechana-74254	108	13	.	.	PUNCT
bibechana-74254	109	1	3.3	3.3	NUM
bibechana-74254	109	2	major	major	ADJ
bibechana-74254	109	3	interaction	interaction	NOUN
bibechana-74254	109	4	involved	involve	VERB
bibechana-74254	109	5	in	in	ADP
bibechana-74254	109	6	the	the	DET
bibechana-74254	109	7	complex	complex	ADJ
bibechana-74254	109	8	formation	formation	NOUN
bibechana-74254	109	9	and	and	CCONJ
bibechana-74254	109	10	stabilization	stabilization	NOUN
bibechana-74254	109	11	to	to	PART
bibechana-74254	109	12	understand	understand	VERB
bibechana-74254	109	13	the	the	DET
bibechana-74254	109	14	mechanism	mechanism	NOUN
bibechana-74254	109	15	of	of	ADP
bibechana-74254	109	16	the	the	DET
bibechana-74254	109	17	interaction	interaction	NOUN
bibechana-74254	109	18	of	of	ADP
bibechana-74254	109	19	hdac2	hdac2	NOUN
bibechana-74254	109	20	with	with	ADP
bibechana-74254	109	21	mta1	mta1	PROPN
bibechana-74254	109	22	,	,	PUNCT
bibechana-74254	109	23	we	we	PRON
bibechana-74254	109	24	explored	explore	VERB
bibechana-74254	109	25	their	their	PRON
bibechana-74254	109	26	dynamics	dynamic	NOUN
bibechana-74254	109	27	during	during	ADP
bibechana-74254	109	28	the	the	DET
bibechana-74254	109	29	simulation	simulation	NOUN
bibechana-74254	109	30	of	of	ADP
bibechana-74254	109	31	the	the	DET
bibechana-74254	109	32	complex	complex	NOUN
bibechana-74254	109	33	.	.	PUNCT
bibechana-74254	110	1	to	to	PART
bibechana-74254	110	2	identify	identify	VERB
bibechana-74254	110	3	the	the	DET
bibechana-74254	110	4	inter	inter	ADJ
bibechana-74254	110	5	-	-	ADJ
bibechana-74254	110	6	protein	protein	ADJ
bibechana-74254	110	7	interactions	interaction	NOUN
bibechana-74254	110	8	,	,	PUNCT
bibechana-74254	110	9	we	we	PRON
bibechana-74254	110	10	evaluated	evaluate	VERB
bibechana-74254	110	11	alphafold	alphafold	ADJ
bibechana-74254	110	12	protein	protein	NOUN
bibechana-74254	110	13	-	-	PUNCT
bibechana-74254	110	14	protein	protein	NOUN
bibechana-74254	110	15	interaction	interaction	NOUN
bibechana-74254	110	16	with	with	ADP
bibechana-74254	110	17	chimerax	chimerax	NOUN
bibechana-74254	110	18	in	in	ADP
bibechana-74254	110	19	the	the	DET
bibechana-74254	110	20	predicted	predict	VERB
bibechana-74254	110	21	complex	complex	ADJ
bibechana-74254	110	22	structure	structure	NOUN
bibechana-74254	110	23	of	of	ADP
bibechana-74254	110	24	the	the	DET
bibechana-74254	110	25	hdac2	hdac2	NOUN
bibechana-74254	110	26	and	and	CCONJ
bibechana-74254	110	27	mta1	mta1	NOUN
bibechana-74254	110	28	that	that	PRON
bibechana-74254	110	29	lie	lie	VERB
bibechana-74254	110	30	within	within	ADP
bibechana-74254	110	31	a	a	DET
bibechana-74254	110	32	5	5	NUM
bibechana-74254	110	33	angstrom	angstrom	NOUN
bibechana-74254	110	34	distance	distance	NOUN
bibechana-74254	110	35	in	in	ADP
bibechana-74254	110	36	the	the	DET
bibechana-74254	110	37	hdac2	hdac2	NOUN
bibechana-74254	110	38	-	-	PUNCT
bibechana-74254	110	39	mta1	mta1	PROPN
bibechana-74254	110	40	complex	complex	NOUN
bibechana-74254	110	41	.	.	PUNCT
bibechana-74254	111	1	figure	figure	NOUN
bibechana-74254	111	2	1(d	1(d	NUM
bibechana-74254	111	3	)	)	PUNCT
bibechana-74254	111	4	shows	show	VERB
bibechana-74254	111	5	the	the	DET
bibechana-74254	111	6	structure	structure	NOUN
bibechana-74254	111	7	of	of	ADP
bibechana-74254	111	8	the	the	DET
bibechana-74254	111	9	hdac2	hdac2	NOUN
bibechana-74254	111	10	-	-	PUNCT
bibechana-74254	111	11	mta1	mta1	PROPN
bibechana-74254	111	12	complex	complex	NOUN
bibechana-74254	111	13	,	,	PUNCT
bibechana-74254	111	14	in	in	ADP
bibechana-74254	111	15	which	which	PRON
bibechana-74254	111	16	both	both	DET
bibechana-74254	111	17	proteins	protein	NOUN
bibechana-74254	111	18	are	be	AUX
bibechana-74254	111	19	within	within	ADP
bibechana-74254	111	20	5	5	NUM
bibechana-74254	111	21	angstrom	angstrom	NOUN
bibechana-74254	111	22	to	to	ADP
bibechana-74254	111	23	each	each	DET
bibechana-74254	111	24	other	other	ADJ
bibechana-74254	111	25	.	.	PUNCT
bibechana-74254	112	1	alphafold	alphafold	ADJ
bibechana-74254	112	2	believes	believe	VERB
bibechana-74254	112	3	that	that	SCONJ
bibechana-74254	112	4	blue	blue	ADJ
bibechana-74254	112	5	color	color	NOUN
bibechana-74254	112	6	lines	line	NOUN
bibechana-74254	112	7	have	have	VERB
bibechana-74254	112	8	high	high	ADJ
bibechana-74254	112	9	confidence	confidence	NOUN
bibechana-74254	112	10	,	,	PUNCT
bibechana-74254	112	11	which	which	PRON
bibechana-74254	112	12	means	mean	VERB
bibechana-74254	112	13	residue	residue	NOUN
bibechana-74254	112	14	pairs	pair	NOUN
bibechana-74254	112	15	that	that	PRON
bibechana-74254	112	16	are	be	AUX
bibechana-74254	112	17	close	close	ADJ
bibechana-74254	112	18	to	to	ADP
bibechana-74254	112	19	each	each	DET
bibechana-74254	112	20	other	other	ADJ
bibechana-74254	112	21	,	,	PUNCT
bibechana-74254	112	22	and	and	CCONJ
bibechana-74254	112	23	red	red	ADJ
bibechana-74254	112	24	color	color	NOUN
bibechana-74254	112	25	lines	line	NOUN
bibechana-74254	112	26	indicate	indicate	VERB
bibechana-74254	112	27	that	that	SCONJ
bibechana-74254	112	28	the	the	DET
bibechana-74254	112	29	residue	residue	NOUN
bibechana-74254	112	30	pairs	pair	NOUN
bibechana-74254	112	31	have	have	VERB
bibechana-74254	112	32	low	low	ADJ
bibechana-74254	112	33	confidence	confidence	NOUN
bibechana-74254	112	34	.	.	PUNCT
bibechana-74254	113	1	3.3.1	3.3.1	NUM
bibechana-74254	113	2	hydrogen	hydrogen	NOUN
bibechana-74254	113	3	bonding	bonding	NOUN
bibechana-74254	113	4	between	between	ADP
bibechana-74254	113	5	hdac2	hdac2	NOUN
bibechana-74254	113	6	and	and	CCONJ
bibechana-74254	113	7	mta1	mta1	NOUN
bibechana-74254	113	8	to	to	PART
bibechana-74254	113	9	predict	predict	VERB
bibechana-74254	113	10	the	the	DET
bibechana-74254	113	11	hydrogen	hydrogen	NOUN
bibechana-74254	113	12	bonds	bond	NOUN
bibechana-74254	113	13	formed	form	VERB
bibechana-74254	113	14	between	between	ADP
bibechana-74254	113	15	hdac2	hdac2	NOUN
bibechana-74254	113	16	and	and	CCONJ
bibechana-74254	113	17	mta1	mta1	PROPN
bibechana-74254	113	18	,	,	PUNCT
bibechana-74254	113	19	we	we	PRON
bibechana-74254	113	20	analyzed	analyze	VERB
bibechana-74254	113	21	the	the	DET
bibechana-74254	113	22	data	datum	NOUN
bibechana-74254	113	23	from	from	ADP
bibechana-74254	113	24	the	the	DET
bibechana-74254	113	25	simulation	simulation	NOUN
bibechana-74254	113	26	trajectories	trajectory	NOUN
bibechana-74254	113	27	.	.	PUNCT
bibechana-74254	114	1	this	this	PRON
bibechana-74254	114	2	was	be	AUX
bibechana-74254	114	3	carried	carry	VERB
bibechana-74254	114	4	out	out	ADP
bibechana-74254	114	5	using	use	VERB
bibechana-74254	114	6	the	the	DET
bibechana-74254	114	7	analysis	analysis	NOUN
bibechana-74254	114	8	protocol	protocol	NOUN
bibechana-74254	114	9	outlined	outline	VERB
bibechana-74254	114	10	in	in	ADP
bibechana-74254	114	11	the	the	DET
bibechana-74254	114	12	methods	method	NOUN
bibechana-74254	114	13	section	section	NOUN
bibechana-74254	114	14	.	.	PUNCT
bibechana-74254	115	1	frequently	frequently	ADV
bibechana-74254	115	2	,	,	PUNCT
bibechana-74254	115	3	a	a	DET
bibechana-74254	115	4	specific	specific	ADJ
bibechana-74254	115	5	amino	amino	NOUN
bibechana-74254	115	6	acid	acid	NOUN
bibechana-74254	115	7	in	in	ADP
bibechana-74254	115	8	one	one	NUM
bibechana-74254	115	9	protein	protein	NOUN
bibechana-74254	115	10	would	would	AUX
bibechana-74254	115	11	form	form	VERB
bibechana-74254	115	12	hydrogen	hydrogen	NOUN
bibechana-74254	115	13	bonds	bond	NOUN
bibechana-74254	115	14	with	with	ADP
bibechana-74254	115	15	another	another	DET
bibechana-74254	115	16	protein	protein	NOUN
bibechana-74254	115	17	via	via	ADP
bibechana-74254	115	18	different	different	ADJ
bibechana-74254	115	19	atoms	atom	NOUN
bibechana-74254	115	20	.	.	PUNCT
bibechana-74254	116	1	in	in	ADP
bibechana-74254	116	2	our	our	PRON
bibechana-74254	116	3	simulation	simulation	NOUN
bibechana-74254	116	4	,	,	PUNCT
bibechana-74254	116	5	we	we	PRON
bibechana-74254	116	6	only	only	ADV
bibechana-74254	116	7	took	take	VERB
bibechana-74254	116	8	into	into	ADP
bibechana-74254	116	9	account	account	NOUN
bibechana-74254	116	10	individual	individual	ADJ
bibechana-74254	116	11	bonds	bond	NOUN
bibechana-74254	116	12	that	that	PRON
bibechana-74254	116	13	were	be	AUX
bibechana-74254	116	14	occupying	occupy	VERB
bibechana-74254	116	15	more	more	ADJ
bibechana-74254	116	16	than	than	ADP
bibechana-74254	116	17	25	25	NUM
bibechana-74254	116	18	%	%	NOUN
bibechana-74254	116	19	.	.	PUNCT
bibechana-74254	117	1	table	table	NOUN
bibechana-74254	117	2	1	1	NUM
bibechana-74254	117	3	displays	display	VERB
bibechana-74254	117	4	the	the	DET
bibechana-74254	117	5	occupancies	occupancy	NOUN
bibechana-74254	117	6	of	of	ADP
bibechana-74254	117	7	hydrogen	hydrogen	NOUN
bibechana-74254	117	8	bonds	bond	NOUN
bibechana-74254	117	9	.	.	PUNCT
bibechana-74254	118	1	for	for	ADP
bibechana-74254	118	2	each	each	DET
bibechana-74254	118	3	pair	pair	NOUN
bibechana-74254	118	4	of	of	ADP
bibechana-74254	118	5	residues	residue	NOUN
bibechana-74254	118	6	,	,	PUNCT
bibechana-74254	118	7	the	the	DET
bibechana-74254	118	8	occupancies	occupancy	NOUN
bibechana-74254	118	9	presented	present	VERB
bibechana-74254	118	10	in	in	ADP
bibechana-74254	118	11	table	table	NOUN
bibechana-74254	118	12	1	1	NUM
bibechana-74254	118	13	represent	represent	VERB
bibechana-74254	118	14	the	the	DET
bibechana-74254	118	15	sum	sum	NOUN
bibechana-74254	118	16	of	of	ADP
bibechana-74254	118	17	hydrogen	hydrogen	NOUN
bibechana-74254	118	18	bonding	bonding	NOUN
bibechana-74254	118	19	contributions	contribution	NOUN
bibechana-74254	118	20	from	from	ADP
bibechana-74254	118	21	various	various	ADJ
bibechana-74254	118	22	atoms	atom	NOUN
bibechana-74254	118	23	within	within	ADP
bibechana-74254	118	24	the	the	DET
bibechana-74254	118	25	same	same	ADJ
bibechana-74254	118	26	residue	residue	NOUN
bibechana-74254	118	27	.	.	PUNCT
bibechana-74254	119	1	the	the	DET
bibechana-74254	119	2	time	time	NOUN
bibechana-74254	119	3	evolution	evolution	NOUN
bibechana-74254	119	4	of	of	ADP
bibechana-74254	119	5	each	each	DET
bibechana-74254	119	6	hydrogen	hydrogen	NOUN
bibechana-74254	119	7	bond	bond	NOUN
bibechana-74254	119	8	established	establish	VERB
bibechana-74254	119	9	by	by	ADP
bibechana-74254	119	10	each	each	DET
bibechana-74254	119	11	atom	atom	NOUN
bibechana-74254	119	12	pair	pair	NOUN
bibechana-74254	119	13	from	from	ADP
bibechana-74254	119	14	the	the	DET
bibechana-74254	119	15	analysis	analysis	NOUN
bibechana-74254	119	16	of	of	ADP
bibechana-74254	119	17	the	the	DET
bibechana-74254	119	18	trajectory	trajectory	NOUN
bibechana-74254	119	19	are	be	AUX
bibechana-74254	119	20	shown	show	VERB
bibechana-74254	119	21	in	in	ADP
bibechana-74254	119	22	figure	figure	NOUN
bibechana-74254	119	23	3(a	3(a	NUM
bibechana-74254	119	24	)	)	PUNCT
bibechana-74254	119	25	.	.	PUNCT
bibechana-74254	120	1	the	the	DET
bibechana-74254	120	2	types	type	NOUN
bibechana-74254	120	3	of	of	ADP
bibechana-74254	120	4	atoms	atom	NOUN
bibechana-74254	120	5	are	be	AUX
bibechana-74254	120	6	shown	show	VERB
bibechana-74254	120	7	inside	inside	ADP
bibechana-74254	120	8	parentheses	parenthesis	NOUN
bibechana-74254	120	9	.	.	PUNCT
bibechana-74254	121	1	figure	figure	VERB
bibechana-74254	121	2	3	3	NUM
bibechana-74254	121	3	:	:	PUNCT
bibechana-74254	121	4	(	(	PUNCT
bibechana-74254	121	5	a	a	X
bibechana-74254	121	6	)	)	PUNCT
bibechana-74254	121	7	distance	distance	NOUN
bibechana-74254	121	8	of	of	ADP
bibechana-74254	121	9	hydrogen	hydrogen	NOUN
bibechana-74254	121	10	bonds	bond	NOUN
bibechana-74254	121	11	formed	form	VERB
bibechana-74254	121	12	between	between	ADP
bibechana-74254	121	13	the	the	DET
bibechana-74254	121	14	residues	residue	NOUN
bibechana-74254	121	15	in	in	ADP
bibechana-74254	121	16	hdac2	hdac2	NOUN
bibechana-74254	121	17	and	and	CCONJ
bibechana-74254	121	18	mta1	mta1	PROPN
bibechana-74254	121	19	.	.	PUNCT
bibechana-74254	122	1	the	the	DET
bibechana-74254	122	2	type	type	NOUN
bibechana-74254	122	3	of	of	ADP
bibechana-74254	122	4	atoms	atom	NOUN
bibechana-74254	122	5	that	that	PRON
bibechana-74254	122	6	are	be	AUX
bibechana-74254	122	7	predicted	predict	VERB
bibechana-74254	122	8	to	to	PART
bibechana-74254	122	9	establish	establish	VERB
bibechana-74254	122	10	the	the	DET
bibechana-74254	122	11	contacts	contact	NOUN
bibechana-74254	122	12	are	be	AUX
bibechana-74254	122	13	provided	provide	VERB
bibechana-74254	122	14	inside	inside	ADJ
bibechana-74254	122	15	parentheses	parenthesis	NOUN
bibechana-74254	122	16	of	of	ADP
bibechana-74254	122	17	each	each	DET
bibechana-74254	122	18	residue	residue	NOUN
bibechana-74254	122	19	.	.	PUNCT
bibechana-74254	123	1	(	(	PUNCT
bibechana-74254	123	2	b	b	X
bibechana-74254	123	3	)	)	PUNCT
bibechana-74254	123	4	orientation	orientation	NOUN
bibechana-74254	123	5	of	of	ADP
bibechana-74254	123	6	residues	residue	NOUN
bibechana-74254	123	7	in	in	ADP
bibechana-74254	123	8	both	both	DET
bibechana-74254	123	9	hdac2	hdac2	NOUN
bibechana-74254	123	10	and	and	CCONJ
bibechana-74254	123	11	mta1	mta1	NOUN
bibechana-74254	123	12	that	that	PRON
bibechana-74254	123	13	form	form	VERB
bibechana-74254	123	14	the	the	DET
bibechana-74254	123	15	hydrogen	hydrogen	NOUN
bibechana-74254	123	16	bonds	bond	NOUN
bibechana-74254	123	17	.	.	PUNCT
bibechana-74254	124	1	the	the	DET
bibechana-74254	124	2	crucial	crucial	ADJ
bibechana-74254	124	3	residues	residue	NOUN
bibechana-74254	124	4	are	be	AUX
bibechana-74254	124	5	shown	show	VERB
bibechana-74254	124	6	in	in	ADP
bibechana-74254	124	7	licorice	licorice	NOUN
bibechana-74254	124	8	representation	representation	NOUN
bibechana-74254	124	9	and	and	CCONJ
bibechana-74254	124	10	the	the	DET
bibechana-74254	124	11	black	black	ADJ
bibechana-74254	124	12	dotted	dotted	ADJ
bibechana-74254	124	13	lines	line	NOUN
bibechana-74254	124	14	represent	represent	VERB
bibechana-74254	124	15	the	the	DET
bibechana-74254	124	16	hydrogen	hydrogen	NOUN
bibechana-74254	124	17	bonds	bond	NOUN
bibechana-74254	124	18	.	.	PUNCT
bibechana-74254	125	1	table	table	NOUN
bibechana-74254	125	2	1	1	NUM
bibechana-74254	125	3	:	:	PUNCT
bibechana-74254	125	4	hydrogen	hydrogen	NOUN
bibechana-74254	125	5	bond	bond	NOUN
bibechana-74254	125	6	occupancies	occupancy	NOUN
bibechana-74254	125	7	obtained	obtain	VERB
bibechana-74254	125	8	from	from	ADP
bibechana-74254	125	9	the	the	DET
bibechana-74254	125	10	analysis	analysis	NOUN
bibechana-74254	125	11	of	of	ADP
bibechana-74254	125	12	trajectories	trajectory	NOUN
bibechana-74254	125	13	of	of	ADP
bibechana-74254	125	14	hdac2	hdac2	NOUN
bibechana-74254	125	15	-	-	PUNCT
bibechana-74254	125	16	mta1	mta1	PROPN
bibechana-74254	125	17	simulation	simulation	NOUN
bibechana-74254	125	18	.	.	PUNCT
bibechana-74254	126	1	except	except	SCONJ
bibechana-74254	126	2	tyr15	tyr15	NOUN
bibechana-74254	126	3	-	-	PUNCT
bibechana-74254	126	4	glu195	glu195	NOUN
bibechana-74254	126	5	residues	residue	NOUN
bibechana-74254	126	6	pair	pair	NOUN
bibechana-74254	126	7	,	,	PUNCT
bibechana-74254	126	8	all	all	DET
bibechana-74254	126	9	other	other	ADJ
bibechana-74254	126	10	residues	residue	NOUN
bibechana-74254	126	11	pairs	pair	NOUN
bibechana-74254	126	12	are	be	AUX
bibechana-74254	126	13	involved	involve	VERB
bibechana-74254	126	14	in	in	ADP
bibechana-74254	126	15	the	the	DET
bibechana-74254	126	16	formation	formation	NOUN
bibechana-74254	126	17	of	of	ADP
bibechana-74254	126	18	salt	salt	NOUN
bibechana-74254	126	19	bridges	bridge	NOUN
bibechana-74254	126	20	as	as	ADV
bibechana-74254	126	21	well	well	ADV
bibechana-74254	126	22	as	as	ADP
bibechana-74254	126	23	hydrogen	hydrogen	NOUN
bibechana-74254	126	24	bonds	bond	NOUN
bibechana-74254	126	25	in	in	ADP
bibechana-74254	126	26	the	the	DET
bibechana-74254	126	27	formation	formation	NOUN
bibechana-74254	126	28	of	of	ADP
bibechana-74254	126	29	hdac2	hdac2	NOUN
bibechana-74254	126	30	-	-	PUNCT
bibechana-74254	126	31	mta1	mta1	NOUN
bibechana-74254	126	32	protein	protein	NOUN
bibechana-74254	126	33	complex	complex	NOUN
bibechana-74254	126	34	.	.	PUNCT
bibechana-74254	127	1	hdac2	hdac2	NOUN
bibechana-74254	127	2	mta1	mta1	NOUN
bibechana-74254	127	3	occupancy	occupancy	NOUN
bibechana-74254	127	4	glu186	glu186	VERB
bibechana-74254	127	5	arg168	arg168	PROPN
bibechana-74254	127	6	156.84	156.84	NUM
bibechana-74254	127	7	%	%	NOUN
bibechana-74254	127	8	glu147	glu147	PROPN
bibechana-74254	127	9	arg168	arg168	PROPN
bibechana-74254	127	10	137.00	137.00	NUM
bibechana-74254	127	11	%	%	NOUN
bibechana-74254	127	12	glu163	glu163	NOUN
bibechana-74254	127	13	arg189	arg189	NOUN
bibechana-74254	127	14	130.28	130.28	NUM
bibechana-74254	127	15	%	%	NOUN
bibechana-74254	127	16	tyr15	tyr15	NOUN
bibechana-74254	127	17	glu195	glu195	NOUN
bibechana-74254	127	18	63.64	63.64	NUM
bibechana-74254	127	19	%	%	NOUN
bibechana-74254	127	20	lys166	lys166	NOUN
bibechana-74254	127	21	asp187	asp187	PROPN
bibechana-74254	127	22	58.24	58.24	NUM
bibechana-74254	127	23	%	%	NOUN
bibechana-74254	127	24	lys124	lys124	PROPN
bibechana-74254	127	25	glu195	glu195	PROPN
bibechana-74254	127	26	46.00	46.00	NUM
bibechana-74254	127	27	%	%	NOUN
bibechana-74254	127	28	narayan	narayan	PROPN
bibechana-74254	127	29	gautam	gautam	PROPN
bibechana-74254	127	30	and	and	CCONJ
bibechana-74254	127	31	narayan	narayan	PROPN
bibechana-74254	127	32	p.	p.	NOUN
bibechana-74254	127	33	adhikari/	adhikari/	NUM
bibechana-74254	128	1	bibechana	bibechana	NOUN
bibechana-74254	128	2	22	22	NUM
bibechana-74254	128	3	(	(	PUNCT
bibechana-74254	128	4	2025	2025	NUM
bibechana-74254	128	5	)	)	PUNCT
bibechana-74254	128	6	108	108	NUM
bibechana-74254	128	7	-	-	SYM
bibechana-74254	128	8	115	115	NUM
bibechana-74254	128	9	112	112	NUM
bibechana-74254	128	10	table	table	NOUN
bibechana-74254	128	11	2	2	NUM
bibechana-74254	128	12	:	:	PUNCT
bibechana-74254	128	13	hydrogen	hydrogen	NOUN
bibechana-74254	128	14	bond	bond	NOUN
bibechana-74254	128	15	length	length	NOUN
bibechana-74254	128	16	between	between	ADP
bibechana-74254	128	17	the	the	DET
bibechana-74254	128	18	atoms	atom	NOUN
bibechana-74254	128	19	of	of	ADP
bibechana-74254	128	20	the	the	DET
bibechana-74254	128	21	residues	residue	NOUN
bibechana-74254	128	22	of	of	ADP
bibechana-74254	128	23	hdac2	hdac2	NOUN
bibechana-74254	128	24	and	and	CCONJ
bibechana-74254	128	25	mta1	mta1	NOUN
bibechana-74254	128	26	of	of	ADP
bibechana-74254	128	27	the	the	DET
bibechana-74254	128	28	final	final	ADJ
bibechana-74254	128	29	frame	frame	NOUN
bibechana-74254	128	30	obtained	obtain	VERB
bibechana-74254	128	31	from	from	ADP
bibechana-74254	128	32	the	the	DET
bibechana-74254	128	33	500	500	NUM
bibechana-74254	128	34	ns	ns	NUM
bibechana-74254	128	35	of	of	ADP
bibechana-74254	128	36	the	the	DET
bibechana-74254	128	37	simulation	simulation	NOUN
bibechana-74254	128	38	of	of	ADP
bibechana-74254	128	39	hdac2	hdac2	NOUN
bibechana-74254	128	40	-	-	PUNCT
bibechana-74254	128	41	mta1	mta1	PROPN
bibechana-74254	128	42	complex	complex	ADJ
bibechana-74254	128	43	hdac2	hdac2	NOUN
bibechana-74254	128	44	residues	residue	NOUN
bibechana-74254	128	45	mta1	mta1	NOUN
bibechana-74254	128	46	residues	residue	VERB
bibechana-74254	129	1	bond	bond	NOUN
bibechana-74254	129	2	-	-	PUNCT
bibechana-74254	129	3	length	length	NOUN
bibechana-74254	129	4	(	(	PUNCT
bibechana-74254	129	5	å	å	NOUN
bibechana-74254	129	6	)	)	PUNCT
bibechana-74254	129	7	(	(	PUNCT
bibechana-74254	129	8	mean±s.d	mean±s.d	PROPN
bibechana-74254	129	9	.	.	PUNCT
bibechana-74254	129	10	)	)	PUNCT
bibechana-74254	129	11	glu186(oe2	glu186(oe2	PROPN
bibechana-74254	129	12	)	)	PUNCT
bibechana-74254	129	13	arg168(ne	arg168(ne	PROPN
bibechana-74254	129	14	)	)	PUNCT
bibechana-74254	129	15	2.9±0.17	2.9±0.17	NUM
bibechana-74254	129	16	glu186(oe1	glu186(oe1	NOUN
bibechana-74254	129	17	)	)	PUNCT
bibechana-74254	129	18	arg168(nh2	arg168(nh2	NOUN
bibechana-74254	129	19	)	)	PUNCT
bibechana-74254	129	20	2.9±0.19	2.9±0.19	NUM
bibechana-74254	129	21	glu147(oe2	glu147(oe2	NOUN
bibechana-74254	129	22	)	)	PUNCT
bibechana-74254	129	23	arg168(nh2	arg168(nh2	NOUN
bibechana-74254	129	24	)	)	PUNCT
bibechana-74254	129	25	3.6±0.90	3.6±0.90	NUM
bibechana-74254	129	26	glu147(oe2	glu147(oe2	NOUN
bibechana-74254	129	27	)	)	PUNCT
bibechana-74254	129	28	arg168(nh1	arg168(nh1	NOUN
bibechana-74254	129	29	)	)	PUNCT
bibechana-74254	129	30	3.4±0.79	3.4±0.79	NUM
bibechana-74254	129	31	glu147(oe1	glu147(oe1	NOUN
bibechana-74254	129	32	)	)	PUNCT
bibechana-74254	129	33	arg168(nh1	arg168(nh1	NOUN
bibechana-74254	129	34	)	)	PUNCT
bibechana-74254	129	35	3.3±0.73	3.3±0.73	NUM
bibechana-74254	129	36	glu147(oe1	glu147(oe1	NOUN
bibechana-74254	129	37	)	)	PUNCT
bibechana-74254	129	38	arg168(nh2	arg168(nh2	NOUN
bibechana-74254	129	39	)	)	PUNCT
bibechana-74254	129	40	3.5±0.87	3.5±0.87	NUM
bibechana-74254	129	41	glu163(oe2	glu163(oe2	NOUN
bibechana-74254	129	42	)	)	PUNCT
bibechana-74254	129	43	arg189(ne	arg189(ne	ADP
bibechana-74254	129	44	)	)	PUNCT
bibechana-74254	129	45	3.4±0.49	3.4±0.49	NUM
bibechana-74254	129	46	glu163(oe1	glu163(oe1	NOUN
bibechana-74254	129	47	)	)	PUNCT
bibechana-74254	129	48	arg189(nh2	arg189(nh2	PROPN
bibechana-74254	129	49	)	)	PUNCT
bibechana-74254	129	50	3.1±0.38	3.1±0.38	NUM
bibechana-74254	129	51	glu163(oe2	glu163(oe2	NOUN
bibechana-74254	129	52	)	)	PUNCT
bibechana-74254	129	53	arg189(nh2	arg189(nh2	PROPN
bibechana-74254	129	54	)	)	PUNCT
bibechana-74254	129	55	3.2±0.48	3.2±0.48	NUM
bibechana-74254	129	56	tyr15(oh	tyr15(oh	NOUN
bibechana-74254	129	57	)	)	PUNCT
bibechana-74254	129	58	glu195(oe1	glu195(oe1	NOUN
bibechana-74254	129	59	)	)	PUNCT
bibechana-74254	129	60	3.2±0.80	3.2±0.80	NUM
bibechana-74254	129	61	lys166(nz	lys166(nz	PROPN
bibechana-74254	129	62	)	)	PUNCT
bibechana-74254	129	63	asp187(od1	asp187(od1	NOUN
bibechana-74254	129	64	)	)	PUNCT
bibechana-74254	129	65	3.4±1.31	3.4±1.31	NUM
bibechana-74254	129	66	lys124(nz	lys124(nz	NOUN
bibechana-74254	129	67	)	)	PUNCT
bibechana-74254	129	68	glu195(oe2	glu195(oe2	PROPN
bibechana-74254	129	69	)	)	PUNCT
bibechana-74254	129	70	2.8±0.26	2.8±0.26	NUM
bibechana-74254	129	71	3.3.2	3.3.2	NUM
bibechana-74254	129	72	contribution	contribution	NOUN
bibechana-74254	129	73	of	of	ADP
bibechana-74254	129	74	a	a	DET
bibechana-74254	129	75	salt	salt	NOUN
bibechana-74254	129	76	bridge	bridge	NOUN
bibechana-74254	129	77	for	for	ADP
bibechana-74254	129	78	the	the	DET
bibechana-74254	129	79	formation	formation	NOUN
bibechana-74254	129	80	of	of	ADP
bibechana-74254	129	81	the	the	DET
bibechana-74254	129	82	hdac7	hdac7	PROPN
bibechana-74254	129	83	-	-	PUNCT
bibechana-74254	129	84	mef2a	mef2a	PROPN
bibechana-74254	129	85	complex	complex	ADJ
bibechana-74254	129	86	figure	figure	NOUN
bibechana-74254	129	87	4	4	NUM
bibechana-74254	129	88	:	:	PUNCT
bibechana-74254	129	89	(	(	PUNCT
bibechana-74254	129	90	a	a	X
bibechana-74254	129	91	)	)	PUNCT
bibechana-74254	129	92	time	time	NOUN
bibechana-74254	129	93	evolution	evolution	NOUN
bibechana-74254	129	94	of	of	ADP
bibechana-74254	129	95	formation	formation	NOUN
bibechana-74254	129	96	of	of	ADP
bibechana-74254	129	97	salt	salt	NOUN
bibechana-74254	129	98	bridges	bridge	NOUN
bibechana-74254	129	99	between	between	ADP
bibechana-74254	129	100	hdac2	hdac2	NOUN
bibechana-74254	129	101	and	and	CCONJ
bibechana-74254	129	102	mta1	mta1	NOUN
bibechana-74254	129	103	during	during	ADP
bibechana-74254	129	104	the	the	DET
bibechana-74254	129	105	complex	complex	ADJ
bibechana-74254	129	106	formation	formation	NOUN
bibechana-74254	129	107	.	.	PUNCT
bibechana-74254	130	1	(	(	PUNCT
bibechana-74254	130	2	b),(c	b),(c	NOUN
bibechana-74254	130	3	)	)	PUNCT
bibechana-74254	130	4	and	and	CCONJ
bibechana-74254	130	5	(	(	PUNCT
bibechana-74254	130	6	d	d	NOUN
bibechana-74254	130	7	)	)	PUNCT
bibechana-74254	130	8	orientation	orientation	NOUN
bibechana-74254	130	9	of	of	ADP
bibechana-74254	130	10	the	the	DET
bibechana-74254	130	11	residues	residue	NOUN
bibechana-74254	130	12	that	that	PRON
bibechana-74254	130	13	formed	form	VERB
bibechana-74254	130	14	salt	salt	NOUN
bibechana-74254	130	15	bridges	bridge	NOUN
bibechana-74254	130	16	in	in	ADP
bibechana-74254	130	17	licorice	licorice	NOUN
bibechana-74254	130	18	form	form	NOUN
bibechana-74254	130	19	.	.	PUNCT
bibechana-74254	131	1	lys124	lys124	NOUN
bibechana-74254	131	2	of	of	ADP
bibechana-74254	131	3	hdac2	hdac2	NOUN
bibechana-74254	131	4	and	and	CCONJ
bibechana-74254	131	5	glu195	glu195	PROPN
bibechana-74254	131	6	of	of	ADP
bibechana-74254	131	7	mta1	mta1	NOUN
bibechana-74254	131	8	form	form	VERB
bibechana-74254	131	9	a	a	DET
bibechana-74254	131	10	strong	strong	ADJ
bibechana-74254	131	11	salt	salt	NOUN
bibechana-74254	131	12	bridge	bridge	NOUN
bibechana-74254	131	13	,	,	PUNCT
bibechana-74254	131	14	despite	despite	SCONJ
bibechana-74254	131	15	the	the	DET
bibechana-74254	131	16	hydrogen	hydrogen	NOUN
bibechana-74254	131	17	bond	bond	NOUN
bibechana-74254	131	18	occupancy	occupancy	NOUN
bibechana-74254	131	19	being	be	AUX
bibechana-74254	131	20	relatively	relatively	ADV
bibechana-74254	131	21	low	low	ADJ
bibechana-74254	131	22	at	at	ADP
bibechana-74254	131	23	only	only	ADV
bibechana-74254	131	24	46.00	46.00	NUM
bibechana-74254	131	25	%	%	NOUN
bibechana-74254	131	26	.	.	PUNCT
bibechana-74254	132	1	this	this	DET
bibechana-74254	132	2	salt	salt	NOUN
bibechana-74254	132	3	bridge	bridge	NOUN
bibechana-74254	132	4	is	be	AUX
bibechana-74254	132	5	crucial	crucial	ADJ
bibechana-74254	132	6	for	for	ADP
bibechana-74254	132	7	establishing	establish	VERB
bibechana-74254	132	8	the	the	DET
bibechana-74254	132	9	linkage	linkage	NOUN
bibechana-74254	132	10	between	between	ADP
bibechana-74254	132	11	hdac2	hdac2	NOUN
bibechana-74254	132	12	and	and	CCONJ
bibechana-74254	132	13	mta1	mta1	PROPN
bibechana-74254	132	14	,	,	PUNCT
bibechana-74254	132	15	as	as	SCONJ
bibechana-74254	132	16	shown	show	VERB
bibechana-74254	132	17	in	in	ADP
bibechana-74254	132	18	the	the	DET
bibechana-74254	132	19	figure	figure	NOUN
bibechana-74254	132	20	4(a	4(a	NUM
bibechana-74254	132	21	)	)	PUNCT
bibechana-74254	132	22	and	and	CCONJ
bibechana-74254	132	23	4(b	4(b	NUM
bibechana-74254	132	24	)	)	PUNCT
bibechana-74254	132	25	respectively	respectively	ADV
bibechana-74254	132	26	.	.	PUNCT
bibechana-74254	133	1	three	three	NUM
bibechana-74254	133	2	additional	additional	ADJ
bibechana-74254	133	3	salt	salt	NOUN
bibechana-74254	133	4	bridges	bridge	NOUN
bibechana-74254	133	5	that	that	PRON
bibechana-74254	133	6	we	we	PRON
bibechana-74254	133	7	predicted	predict	VERB
bibechana-74254	133	8	are	be	AUX
bibechana-74254	133	9	:	:	PUNCT
bibechana-74254	133	10	glu147(hdac2)-arg168(mta1	glu147(hdac2)-arg168(mta1	X
bibechana-74254	133	11	)	)	PUNCT
bibechana-74254	133	12	,	,	PUNCT
bibechana-74254	133	13	glu163(hdac2)-arg189(mta1	glu163(hdac2)-arg189(mta1	NOUN
bibechana-74254	133	14	)	)	PUNCT
bibechana-74254	133	15	,	,	PUNCT
bibechana-74254	133	16	and	and	CCONJ
bibechana-74254	133	17	glu186(hdac2)−arg168(mta1	glu186(hdac2)−arg168(mta1	NOUN
bibechana-74254	133	18	)	)	PUNCT
bibechana-74254	133	19	,	,	PUNCT
bibechana-74254	133	20	performed	perform	VERB
bibechana-74254	133	21	nearly	nearly	ADV
bibechana-74254	133	22	equal	equal	ADJ
bibechana-74254	133	23	contributions	contribution	NOUN
bibechana-74254	133	24	to	to	ADP
bibechana-74254	133	25	the	the	DET
bibechana-74254	133	26	formation	formation	NOUN
bibechana-74254	133	27	of	of	ADP
bibechana-74254	133	28	the	the	DET
bibechana-74254	133	29	hdac2	hdac2	NOUN
bibechana-74254	133	30	-	-	PUNCT
bibechana-74254	133	31	mta1	mta1	PROPN
bibechana-74254	133	32	complex	complex	NOUN
bibechana-74254	133	33	.	.	PUNCT
bibechana-74254	134	1	the	the	DET
bibechana-74254	134	2	salt	salt	NOUN
bibechana-74254	134	3	bridges	bridge	NOUN
bibechana-74254	134	4	exhibit	exhibit	VERB
bibechana-74254	134	5	stability	stability	NOUN
bibechana-74254	134	6	throughout	throughout	ADP
bibechana-74254	134	7	the	the	DET
bibechana-74254	134	8	500	500	NUM
bibechana-74254	134	9	ns	ns	NUM
bibechana-74254	134	10	simulation	simulation	NOUN
bibechana-74254	134	11	.	.	PUNCT
bibechana-74254	135	1	the	the	DET
bibechana-74254	135	2	remaining	remain	VERB
bibechana-74254	135	3	salt	salt	NOUN
bibechana-74254	135	4	bridge	bridge	NOUN
bibechana-74254	135	5	that	that	PRON
bibechana-74254	135	6	we	we	PRON
bibechana-74254	135	7	predicted	predict	VERB
bibechana-74254	135	8	is	be	AUX
bibechana-74254	135	9	lys166(hdac2)-asp187(mta1	lys166(hdac2)-asp187(mta1	NOUN
bibechana-74254	135	10	)	)	PUNCT
bibechana-74254	135	11	and	and	CCONJ
bibechana-74254	135	12	the	the	DET
bibechana-74254	135	13	stability	stability	NOUN
bibechana-74254	135	14	of	of	ADP
bibechana-74254	135	15	this	this	DET
bibechana-74254	135	16	salt	salt	NOUN
bibechana-74254	135	17	bridge	bridge	NOUN
bibechana-74254	135	18	remains	remain	VERB
bibechana-74254	135	19	constant	constant	ADJ
bibechana-74254	135	20	throughout	throughout	ADP
bibechana-74254	135	21	the	the	DET
bibechana-74254	135	22	simulation	simulation	NOUN
bibechana-74254	135	23	,	,	PUNCT
bibechana-74254	135	24	except	except	SCONJ
bibechana-74254	135	25	for	for	ADP
bibechana-74254	135	26	the	the	DET
bibechana-74254	135	27	time	time	NOUN
bibechana-74254	135	28	period	period	NOUN
bibechana-74254	135	29	between	between	ADP
bibechana-74254	135	30	380	380	NUM
bibechana-74254	135	31	ns	ns	NUM
bibechana-74254	135	32	and	and	CCONJ
bibechana-74254	135	33	410	410	NUM
bibechana-74254	135	34	ns	ns	NOUN
bibechana-74254	135	35	.	.	PROPN
bibechana-74254	135	36	figure	figure	NOUN
bibechana-74254	135	37	4(b	4(b	NUM
bibechana-74254	135	38	)	)	PUNCT
bibechana-74254	135	39	shows	show	VERB
bibechana-74254	135	40	the	the	DET
bibechana-74254	135	41	precise	precise	ADJ
bibechana-74254	135	42	orientation	orientation	NOUN
bibechana-74254	135	43	of	of	ADP
bibechana-74254	135	44	all	all	DET
bibechana-74254	135	45	these	these	DET
bibechana-74254	135	46	residues	residue	NOUN
bibechana-74254	135	47	that	that	PRON
bibechana-74254	135	48	form	form	VERB
bibechana-74254	135	49	the	the	DET
bibechana-74254	135	50	hdac2	hdac2	NOUN
bibechana-74254	135	51	-	-	PUNCT
bibechana-74254	135	52	mta1	mta1	PROPN
bibechana-74254	135	53	complex	complex	NOUN
bibechana-74254	135	54	within	within	ADP
bibechana-74254	135	55	each	each	DET
bibechana-74254	135	56	protein	protein	NOUN
bibechana-74254	135	57	.	.	PUNCT
bibechana-74254	136	1	3.3.3	3.3.3	NUM
bibechana-74254	136	2	contribution	contribution	NOUN
bibechana-74254	136	3	due	due	ADP
bibechana-74254	136	4	to	to	ADP
bibechana-74254	136	5	hydrophobic	hydrophobic	NOUN
bibechana-74254	136	6	interactions	interaction	NOUN
bibechana-74254	136	7	figure	figure	NOUN
bibechana-74254	136	8	5	5	NUM
bibechana-74254	136	9	:	:	PUNCT
bibechana-74254	136	10	(	(	PUNCT
bibechana-74254	136	11	a	a	X
bibechana-74254	136	12	)	)	PUNCT
bibechana-74254	136	13	regions	region	NOUN
bibechana-74254	136	14	of	of	ADP
bibechana-74254	136	15	hydrophobic	hydrophobic	NOUN
bibechana-74254	136	16	residues	residue	NOUN
bibechana-74254	136	17	that	that	PRON
bibechana-74254	136	18	form	form	VERB
bibechana-74254	136	19	hydrophobic	hydrophobic	NOUN
bibechana-74254	136	20	interaction	interaction	NOUN
bibechana-74254	136	21	between	between	ADP
bibechana-74254	136	22	hdac2	hdac2	NOUN
bibechana-74254	136	23	and	and	CCONJ
bibechana-74254	136	24	mta1	mta1	PROPN
bibechana-74254	136	25	,	,	PUNCT
bibechana-74254	136	26	and	and	CCONJ
bibechana-74254	136	27	(	(	PUNCT
bibechana-74254	136	28	b	b	X
bibechana-74254	136	29	)	)	PUNCT
bibechana-74254	136	30	hydrophobic	hydrophobic	NOUN
bibechana-74254	136	31	residues	residue	NOUN
bibechana-74254	136	32	in	in	ADP
bibechana-74254	136	33	hdac2	hdac2	NOUN
bibechana-74254	136	34	(	(	PUNCT
bibechana-74254	136	35	magenta	magenta	NOUN
bibechana-74254	136	36	texts	text	NOUN
bibechana-74254	136	37	)	)	PUNCT
bibechana-74254	136	38	that	that	PRON
bibechana-74254	136	39	establish	establish	VERB
bibechana-74254	136	40	hydrophobic	hydrophobic	NOUN
bibechana-74254	136	41	interactions	interaction	NOUN
bibechana-74254	136	42	with	with	ADP
bibechana-74254	136	43	mta1	mta1	NOUN
bibechana-74254	136	44	residues	residue	NOUN
bibechana-74254	136	45	(	(	PUNCT
bibechana-74254	136	46	orange	orange	ADJ
bibechana-74254	136	47	red	red	ADJ
bibechana-74254	136	48	texts	text	NOUN
bibechana-74254	136	49	)	)	PUNCT
bibechana-74254	136	50	with	with	ADP
bibechana-74254	136	51	surface	surface	NOUN
bibechana-74254	136	52	and	and	CCONJ
bibechana-74254	136	53	licorice	licorice	NOUN
bibechana-74254	136	54	representation	representation	NOUN
bibechana-74254	136	55	.	.	PUNCT
bibechana-74254	137	1	the	the	DET
bibechana-74254	137	2	hydrophobic	hydrophobic	NOUN
bibechana-74254	137	3	interactions	interaction	NOUN
bibechana-74254	137	4	play	play	VERB
bibechana-74254	137	5	a	a	DET
bibechana-74254	137	6	crucial	crucial	ADJ
bibechana-74254	137	7	role	role	NOUN
bibechana-74254	137	8	in	in	ADP
bibechana-74254	137	9	the	the	DET
bibechana-74254	137	10	formation	formation	NOUN
bibechana-74254	137	11	and	and	CCONJ
bibechana-74254	137	12	stabilization	stabilization	NOUN
bibechana-74254	137	13	of	of	ADP
bibechana-74254	137	14	the	the	DET
bibechana-74254	137	15	complex	complex	NOUN
bibechana-74254	137	16	between	between	ADP
bibechana-74254	137	17	hdac2	hdac2	NOUN
bibechana-74254	137	18	and	and	CCONJ
bibechana-74254	137	19	mta1	mta1	PROPN
bibechana-74254	137	20	.	.	PUNCT
bibechana-74254	138	1	our	our	PRON
bibechana-74254	138	2	results	result	NOUN
bibechana-74254	138	3	show	show	VERB
bibechana-74254	138	4	that	that	SCONJ
bibechana-74254	138	5	there	there	PRON
bibechana-74254	138	6	are	be	VERB
bibechana-74254	138	7	a	a	DET
bibechana-74254	138	8	number	number	NOUN
bibechana-74254	138	9	of	of	ADP
bibechana-74254	138	10	hydrophobic	hydrophobic	NOUN
bibechana-74254	138	11	interactions	interaction	NOUN
bibechana-74254	138	12	between	between	ADP
bibechana-74254	138	13	residues	residue	NOUN
bibechana-74254	138	14	in	in	ADP
bibechana-74254	138	15	hdac2	hdac2	NOUN
bibechana-74254	138	16	and	and	CCONJ
bibechana-74254	138	17	mta1	mta1	NOUN
bibechana-74254	138	18	across	across	ADP
bibechana-74254	138	19	the	the	DET
bibechana-74254	138	20	interface	interface	NOUN
bibechana-74254	138	21	.	.	PUNCT
bibechana-74254	139	1	we	we	PRON
bibechana-74254	139	2	predicted	predict	VERB
bibechana-74254	139	3	that	that	SCONJ
bibechana-74254	139	4	hydrophobic	hydrophobic	NOUN
bibechana-74254	139	5	residues	residue	NOUN
bibechana-74254	139	6	ile54	ile54	NOUN
bibechana-74254	139	7	,	,	PUNCT
bibechana-74254	139	8	val119	val119	PROPN
bibechana-74254	139	9	,	,	PUNCT
bibechana-74254	139	10	ala120	ala120	PROPN
bibechana-74254	139	11	,	,	PUNCT
bibechana-74254	139	12	val123	val123	PROPN
bibechana-74254	139	13	,	,	PUNCT
bibechana-74254	139	14	leu162	leu162	PROPN
bibechana-74254	139	15	,	,	PUNCT
bibechana-74254	139	16	leu165	leu165	PROPN
bibechana-74254	139	17	,	,	PUNCT
bibechana-74254	139	18	ala187	ala187	PROPN
bibechana-74254	139	19	,	,	PUNCT
bibechana-74254	139	20	phe188	phe188	PROPN
bibechana-74254	139	21	,	,	PUNCT
bibechana-74254	139	22	ile408	ile408	PROPN
bibechana-74254	139	23	,	,	PUNCT
bibechana-74254	139	24	ala410	ala410	PROPN
bibechana-74254	139	25	of	of	ADP
bibechana-74254	139	26	hdac2	hdac2	NOUN
bibechana-74254	139	27	make	make	VERB
bibechana-74254	139	28	hydrophobic	hydrophobic	NOUN
bibechana-74254	139	29	interactions	interaction	NOUN
bibechana-74254	139	30	with	with	ADP
bibechana-74254	139	31	ala175	ala175	PROPN
bibechana-74254	139	32	,	,	PUNCT
bibechana-74254	139	33	ile177	ile177	ADJ
bibechana-74254	139	34	,	,	PUNCT
bibechana-74254	139	35	leu180	leu180	PROPN
bibechana-74254	139	36	,	,	PUNCT
bibechana-74254	139	37	leu181	leu181	PROPN
bibechana-74254	139	38	,	,	PUNCT
bibechana-74254	139	39	leu194	leu194	PROPN
bibechana-74254	139	40	,	,	PUNCT
bibechana-74254	139	41	val198	val198	PROPN
bibechana-74254	139	42	,	,	PUNCT
bibechana-74254	139	43	trp199	trp199	NOUN
bibechana-74254	139	44	of	of	ADP
bibechana-74254	139	45	mta1	mta1	PROPN
bibechana-74254	139	46	.	.	PUNCT
bibechana-74254	140	1	although	although	SCONJ
bibechana-74254	140	2	there	there	PRON
bibechana-74254	140	3	are	be	VERB
bibechana-74254	140	4	many	many	ADJ
bibechana-74254	140	5	hydrophobic	hydrophobic	ADJ
bibechana-74254	140	6	interactions	interaction	NOUN
bibechana-74254	140	7	in	in	ADP
bibechana-74254	140	8	the	the	DET
bibechana-74254	140	9	formation	formation	NOUN
bibechana-74254	140	10	of	of	ADP
bibechana-74254	140	11	hdac2	hdac2	NOUN
bibechana-74254	140	12	-	-	PUNCT
bibechana-74254	140	13	mta1	mta1	PROPN
bibechana-74254	140	14	complex	complex	NOUN
bibechana-74254	140	15	,	,	PUNCT
bibechana-74254	140	16	the	the	DET
bibechana-74254	140	17	crucial	crucial	ADJ
bibechana-74254	140	18	residues	residue	NOUN
bibechana-74254	140	19	that	that	PRON
bibechana-74254	140	20	form	form	VERB
bibechana-74254	140	21	hydrophobic	hydrophobic	NOUN
bibechana-74254	140	22	interaction	interaction	NOUN
bibechana-74254	140	23	is	be	AUX
bibechana-74254	140	24	shown	show	VERB
bibechana-74254	140	25	in	in	ADP
bibechana-74254	140	26	figure	figure	NOUN
bibechana-74254	140	27	5(a	5(a	NUM
bibechana-74254	140	28	)	)	PUNCT
bibechana-74254	140	29	.	.	PUNCT
bibechana-74254	141	1	the	the	DET
bibechana-74254	141	2	zoom	zoom	NOUN
bibechana-74254	141	3	viewed	view	VERB
bibechana-74254	141	4	of	of	ADP
bibechana-74254	141	5	figure	figure	NOUN
bibechana-74254	141	6	5(a	5(a	NUM
bibechana-74254	141	7	)	)	PUNCT
bibechana-74254	141	8	is	be	AUX
bibechana-74254	141	9	shown	show	VERB
bibechana-74254	141	10	in	in	ADP
bibechana-74254	141	11	figure	figure	NOUN
bibechana-74254	141	12	5(b	5(b	NUM
bibechana-74254	141	13	)	)	PUNCT
bibechana-74254	141	14	in	in	ADP
bibechana-74254	141	15	surface	surface	NOUN
bibechana-74254	141	16	and	and	CCONJ
bibechana-74254	141	17	licorice	licorice	NOUN
bibechana-74254	141	18	representation	representation	NOUN
bibechana-74254	141	19	with	with	ADP
bibechana-74254	141	20	label	label	NOUN
bibechana-74254	141	21	.	.	PUNCT
bibechana-74254	142	1	narayan	narayan	PROPN
bibechana-74254	142	2	gautam	gautam	PROPN
bibechana-74254	142	3	and	and	CCONJ
bibechana-74254	142	4	narayan	narayan	PROPN
bibechana-74254	142	5	p.	p.	NOUN
bibechana-74254	142	6	adhikari/	adhikari/	NUM
bibechana-74254	142	7	bibechana	bibechana	NOUN
bibechana-74254	142	8	22	22	NUM
bibechana-74254	142	9	(	(	PUNCT
bibechana-74254	142	10	2025	2025	NUM
bibechana-74254	142	11	)	)	PUNCT
bibechana-74254	142	12	108	108	NUM
bibechana-74254	142	13	-	-	SYM
bibechana-74254	142	14	115	115	NUM
bibechana-74254	142	15	113	113	NUM
bibechana-74254	142	16	table	table	NOUN
bibechana-74254	142	17	3	3	NUM
bibechana-74254	142	18	:	:	PUNCT
bibechana-74254	142	19	the	the	DET
bibechana-74254	142	20	hydrophobic	hydrophobic	NOUN
bibechana-74254	142	21	interactions	interaction	NOUN
bibechana-74254	142	22	between	between	ADP
bibechana-74254	142	23	the	the	DET
bibechana-74254	142	24	different	different	ADJ
bibechana-74254	142	25	amino	amino	NOUN
bibechana-74254	142	26	acid	acid	NOUN
bibechana-74254	142	27	residues	residue	NOUN
bibechana-74254	142	28	of	of	ADP
bibechana-74254	142	29	hdac2	hdac2	NOUN
bibechana-74254	142	30	and	and	CCONJ
bibechana-74254	142	31	mta1	mta1	PROPN
bibechana-74254	142	32	.	.	PUNCT
bibechana-74254	143	1	hdac2	hdac2	NOUN
bibechana-74254	143	2	mta1	mta1	PROPN
bibechana-74254	143	3	ile54	ile54	PROPN
bibechana-74254	143	4	val198	val198	PROPN
bibechana-74254	143	5	,	,	PUNCT
bibechana-74254	143	6	trp199	trp199	NOUN
bibechana-74254	143	7	val119	val119	PROPN
bibechana-74254	143	8	leu194	leu194	PROPN
bibechana-74254	143	9	ala120	ala120	PROPN
bibechana-74254	143	10	leu194	leu194	PROPN
bibechana-74254	143	11	val123	val123	PROPN
bibechana-74254	143	12	leu194	leu194	PROPN
bibechana-74254	143	13	leu162	leu162	PROPN
bibechana-74254	143	14	ala175	ala175	PROPN
bibechana-74254	143	15	,	,	PUNCT
bibechana-74254	143	16	ile177	ile177	PROPN
bibechana-74254	143	17	leu165	leu165	PROPN
bibechana-74254	143	18	ile177	ile177	ADJ
bibechana-74254	143	19	,	,	PUNCT
bibechana-74254	143	20	leu180	leu180	PROPN
bibechana-74254	143	21	ala187	ala187	PROPN
bibechana-74254	143	22	ala175	ala175	PROPN
bibechana-74254	144	1	phe188	phe188	PROPN
bibechana-74254	144	2	ile177	ile177	ADJ
bibechana-74254	144	3	ile408	ile408	ADJ
bibechana-74254	144	4	leu180	leu180	NOUN
bibechana-74254	144	5	ala410	ala410	PROPN
bibechana-74254	144	6	leu180	leu180	PROPN
bibechana-74254	144	7	,	,	PUNCT
bibechana-74254	144	8	leu181	leu181	PROPN
bibechana-74254	144	9	as	as	SCONJ
bibechana-74254	144	10	shown	show	VERB
bibechana-74254	144	11	in	in	ADP
bibechana-74254	144	12	figure	figure	NOUN
bibechana-74254	144	13	5(b	5(b	NUM
bibechana-74254	144	14	)	)	PUNCT
bibechana-74254	144	15	,	,	PUNCT
bibechana-74254	144	16	the	the	DET
bibechana-74254	144	17	hydrophobic	hydrophobic	NOUN
bibechana-74254	144	18	residues	residue	NOUN
bibechana-74254	144	19	ile54	ile54	NOUN
bibechana-74254	144	20	of	of	ADP
bibechana-74254	144	21	hdac2	hdac2	NOUN
bibechana-74254	144	22	binds	bind	VERB
bibechana-74254	144	23	strongly	strongly	ADV
bibechana-74254	144	24	with	with	ADP
bibechana-74254	144	25	val198	val198	NOUN
bibechana-74254	144	26	,	,	PUNCT
bibechana-74254	144	27	trp199	trp199	NOUN
bibechana-74254	144	28	of	of	ADP
bibechana-74254	144	29	mta1	mta1	PROPN
bibechana-74254	144	30	.	.	PUNCT
bibechana-74254	145	1	three	three	NUM
bibechana-74254	145	2	amino	amino	NOUN
bibechana-74254	145	3	acid	acid	NOUN
bibechana-74254	145	4	residues	residue	NOUN
bibechana-74254	145	5	val119	val119	PROPN
bibechana-74254	145	6	,	,	PUNCT
bibechana-74254	145	7	ala120	ala120	PROPN
bibechana-74254	145	8	&	&	CCONJ
bibechana-74254	145	9	val123	val123	PROPN
bibechana-74254	145	10	of	of	ADP
bibechana-74254	145	11	hdac2	hdac2	NOUN
bibechana-74254	145	12	make	make	VERB
bibechana-74254	145	13	hydrophobic	hydrophobic	ADJ
bibechana-74254	145	14	cavity	cavity	NOUN
bibechana-74254	145	15	.	.	PUNCT
bibechana-74254	146	1	in	in	ADP
bibechana-74254	146	2	that	that	DET
bibechana-74254	146	3	cavity	cavity	NOUN
bibechana-74254	146	4	,	,	PUNCT
bibechana-74254	146	5	leu194	leu194	NOUN
bibechana-74254	146	6	of	of	ADP
bibechana-74254	146	7	mta1	mta1	NOUN
bibechana-74254	146	8	deeply	deeply	ADV
bibechana-74254	146	9	inserted	insert	VERB
bibechana-74254	146	10	and	and	CCONJ
bibechana-74254	146	11	make	make	VERB
bibechana-74254	146	12	strong	strong	ADJ
bibechana-74254	146	13	interaction	interaction	NOUN
bibechana-74254	146	14	.	.	PUNCT
bibechana-74254	147	1	also	also	ADV
bibechana-74254	147	2	,	,	PUNCT
bibechana-74254	147	3	iile177	iile177	PROPN
bibechana-74254	147	4	and	and	CCONJ
bibechana-74254	147	5	ala175	ala175	PROPN
bibechana-74254	147	6	of	of	ADP
bibechana-74254	147	7	mta1	mta1	NOUN
bibechana-74254	147	8	make	make	VERB
bibechana-74254	147	9	hydrophobic	hydrophobic	NOUN
bibechana-74254	147	10	interactions	interaction	NOUN
bibechana-74254	147	11	with	with	ADP
bibechana-74254	147	12	leu162	leu162	PROPN
bibechana-74254	147	13	,	,	PUNCT
bibechana-74254	147	14	ala187	ala187	PROPN
bibechana-74254	147	15	,	,	PUNCT
bibechana-74254	147	16	and	and	CCONJ
bibechana-74254	147	17	phe188	phe188	PROPN
bibechana-74254	147	18	of	of	ADP
bibechana-74254	147	19	hdac2	hdac2	NOUN
bibechana-74254	147	20	.	.	PUNCT
bibechana-74254	148	1	similarly	similarly	ADV
bibechana-74254	148	2	,	,	PUNCT
bibechana-74254	148	3	leu165	leu165	PROPN
bibechana-74254	148	4	,	,	PUNCT
bibechana-74254	148	5	ile408	ile408	ADJ
bibechana-74254	148	6	,	,	PUNCT
bibechana-74254	148	7	and	and	CCONJ
bibechana-74254	148	8	ala410	ala410	NOUN
bibechana-74254	148	9	of	of	ADP
bibechana-74254	148	10	hdac2	hdac2	NOUN
bibechana-74254	148	11	interact	interact	VERB
bibechana-74254	148	12	with	with	ADP
bibechana-74254	148	13	leu180	leu180	PROPN
bibechana-74254	148	14	and	and	CCONJ
bibechana-74254	148	15	leu181	leu181	PROPN
bibechana-74254	148	16	of	of	ADP
bibechana-74254	148	17	mta1	mta1	PROPN
bibechana-74254	148	18	.	.	PUNCT
bibechana-74254	149	1	we	we	PRON
bibechana-74254	149	2	have	have	AUX
bibechana-74254	149	3	calculated	calculate	VERB
bibechana-74254	149	4	the	the	DET
bibechana-74254	149	5	hydrophobic	hydrophobic	NOUN
bibechana-74254	149	6	contact	contact	NOUN
bibechana-74254	149	7	area	area	NOUN
bibechana-74254	149	8	of	of	ADP
bibechana-74254	149	9	the	the	DET
bibechana-74254	149	10	hdac2	hdac2	NOUN
bibechana-74254	149	11	-	-	PUNCT
bibechana-74254	149	12	mta1	mta1	NOUN
bibechana-74254	149	13	complex	complex	NOUN
bibechana-74254	149	14	by	by	ADP
bibechana-74254	149	15	using	use	VERB
bibechana-74254	149	16	the	the	DET
bibechana-74254	149	17	equation	equation	NOUN
bibechana-74254	149	18	as	as	SCONJ
bibechana-74254	149	19	described	describe	VERB
bibechana-74254	149	20	in	in	ADP
bibechana-74254	149	21	the	the	DET
bibechana-74254	149	22	method	method	NOUN
bibechana-74254	149	23	section	section	NOUN
bibechana-74254	149	24	.	.	PUNCT
bibechana-74254	150	1	figure	figure	NOUN
bibechana-74254	150	2	6(a	6(a	NUM
bibechana-74254	150	3	)	)	PUNCT
bibechana-74254	150	4	shows	show	VERB
bibechana-74254	150	5	the	the	DET
bibechana-74254	150	6	contact	contact	NOUN
bibechana-74254	150	7	area	area	NOUN
bibechana-74254	150	8	measurements	measurement	NOUN
bibechana-74254	150	9	for	for	ADP
bibechana-74254	150	10	the	the	DET
bibechana-74254	150	11	hdac2	hdac2	NOUN
bibechana-74254	150	12	-	-	PUNCT
bibechana-74254	150	13	mta1	mta1	PROPN
bibechana-74254	150	14	complex	complex	NOUN
bibechana-74254	150	15	.	.	PUNCT
bibechana-74254	151	1	we	we	PRON
bibechana-74254	151	2	calculated	calculate	VERB
bibechana-74254	151	3	the	the	DET
bibechana-74254	151	4	average	average	ADJ
bibechana-74254	151	5	and	and	CCONJ
bibechana-74254	151	6	standard	standard	ADJ
bibechana-74254	151	7	deviation	deviation	NOUN
bibechana-74254	151	8	(	(	PUNCT
bibechana-74254	151	9	s.d	s.d	PROPN
bibechana-74254	151	10	.	.	PROPN
bibechana-74254	151	11	)	)	PUNCT
bibechana-74254	151	12	of	of	ADP
bibechana-74254	151	13	all	all	DET
bibechana-74254	151	14	contact	contact	NOUN
bibechana-74254	151	15	area	area	NOUN
bibechana-74254	151	16	values	value	NOUN
bibechana-74254	151	17	(	(	PUNCT
bibechana-74254	151	18	values	value	NOUN
bibechana-74254	151	19	for	for	ADP
bibechana-74254	151	20	each	each	DET
bibechana-74254	151	21	frame	frame	NOUN
bibechana-74254	151	22	of	of	ADP
bibechana-74254	151	23	entire	entire	ADJ
bibechana-74254	151	24	500	500	NUM
bibechana-74254	151	25	ns	ns	NUM
bibechana-74254	151	26	simulations	simulation	NOUN
bibechana-74254	151	27	)	)	PUNCT
bibechana-74254	151	28	as	as	SCONJ
bibechana-74254	151	29	shown	show	VERB
bibechana-74254	151	30	in	in	ADP
bibechana-74254	151	31	figure	figure	NOUN
bibechana-74254	151	32	6(a	6(a	NUM
bibechana-74254	151	33	)	)	PUNCT
bibechana-74254	151	34	and	and	CCONJ
bibechana-74254	151	35	obtained	obtain	VERB
bibechana-74254	151	36	243.89±23.44	243.89±23.44	NUM
bibechana-74254	151	37	å2	å2	NOUN
bibechana-74254	151	38	(	(	PUNCT
bibechana-74254	151	39	mean±s.d	mean±s.d	PROPN
bibechana-74254	151	40	.	.	PUNCT
bibechana-74254	151	41	)	)	PUNCT
bibechana-74254	151	42	.	.	PUNCT
bibechana-74254	152	1	the	the	DET
bibechana-74254	152	2	time	time	NOUN
bibechana-74254	152	3	evolution	evolution	NOUN
bibechana-74254	152	4	of	of	ADP
bibechana-74254	152	5	hydrophobic	hydrophobic	NOUN
bibechana-74254	152	6	contact	contact	NOUN
bibechana-74254	152	7	area	area	NOUN
bibechana-74254	152	8	was	be	AUX
bibechana-74254	152	9	monitored	monitor	VERB
bibechana-74254	152	10	over	over	ADP
bibechana-74254	152	11	a	a	DET
bibechana-74254	152	12	500	500	NUM
bibechana-74254	152	13	ns	ns	NUM
bibechana-74254	152	14	molecular	molecular	ADJ
bibechana-74254	152	15	dynamics	dynamic	NOUN
bibechana-74254	152	16	simulation	simulation	NOUN
bibechana-74254	152	17	,	,	PUNCT
bibechana-74254	152	18	as	as	SCONJ
bibechana-74254	152	19	shown	show	VERB
bibechana-74254	152	20	in	in	ADP
bibechana-74254	152	21	figure	figure	NOUN
bibechana-74254	152	22	.	.	PUNCT
bibechana-74254	153	1	at	at	ADP
bibechana-74254	153	2	the	the	DET
bibechana-74254	153	3	initial	initial	ADJ
bibechana-74254	153	4	phase	phase	NOUN
bibechana-74254	153	5	,	,	PUNCT
bibechana-74254	153	6	the	the	DET
bibechana-74254	153	7	contact	contact	NOUN
bibechana-74254	153	8	area	area	NOUN
bibechana-74254	153	9	is	be	AUX
bibechana-74254	153	10	stable	stable	ADJ
bibechana-74254	153	11	and	and	CCONJ
bibechana-74254	153	12	is	be	AUX
bibechana-74254	153	13	predominantly	predominantly	ADV
bibechana-74254	153	14	fluctuated	fluctuate	VERB
bibechana-74254	153	15	between	between	ADP
bibechana-74254	153	16	200	200	NUM
bibechana-74254	153	17	and	and	CCONJ
bibechana-74254	153	18	250	250	NUM
bibechana-74254	153	19	å2	å2	NOUN
bibechana-74254	153	20	,	,	PUNCT
bibechana-74254	153	21	which	which	PRON
bibechana-74254	153	22	represent	represent	VERB
bibechana-74254	153	23	the	the	DET
bibechana-74254	153	24	relatively	relatively	ADV
bibechana-74254	153	25	stable	stable	ADJ
bibechana-74254	153	26	interactions	interaction	NOUN
bibechana-74254	153	27	with	with	ADP
bibechana-74254	153	28	minor	minor	ADJ
bibechana-74254	153	29	fluctuations	fluctuation	NOUN
bibechana-74254	153	30	.	.	PUNCT
bibechana-74254	154	1	after	after	ADP
bibechana-74254	154	2	350	350	NUM
bibechana-74254	154	3	-	-	SYM
bibechana-74254	154	4	500	500	NUM
bibechana-74254	154	5	ns	ns	NUM
bibechana-74254	154	6	,	,	PUNCT
bibechana-74254	154	7	the	the	DET
bibechana-74254	154	8	contact	contact	NOUN
bibechana-74254	154	9	area	area	NOUN
bibechana-74254	154	10	is	be	AUX
bibechana-74254	154	11	increased	increase	VERB
bibechana-74254	154	12	,	,	PUNCT
bibechana-74254	154	13	with	with	ADP
bibechana-74254	154	14	peak	peak	NOUN
bibechana-74254	154	15	values	value	NOUN
bibechana-74254	154	16	reaching	reach	VERB
bibechana-74254	154	17	approximately	approximately	ADV
bibechana-74254	154	18	about	about	ADV
bibechana-74254	154	19	340	340	NUM
bibechana-74254	154	20	å2	å2	NOUN
bibechana-74254	154	21	.	.	PUNCT
bibechana-74254	155	1	the	the	DET
bibechana-74254	155	2	higher	high	ADJ
bibechana-74254	155	3	contact	contact	NOUN
bibechana-74254	155	4	area	area	NOUN
bibechana-74254	155	5	after	after	SCONJ
bibechana-74254	155	6	350	350	NUM
bibechana-74254	155	7	ns	ns	NUM
bibechana-74254	155	8	is	be	AUX
bibechana-74254	155	9	due	due	ADJ
bibechana-74254	155	10	to	to	ADP
bibechana-74254	155	11	the	the	DET
bibechana-74254	155	12	formation	formation	NOUN
bibechana-74254	155	13	of	of	ADP
bibechana-74254	155	14	new	new	ADJ
bibechana-74254	155	15	hydrophobic	hydrophobic	NOUN
bibechana-74254	155	16	contacts	contact	NOUN
bibechana-74254	155	17	between	between	ADP
bibechana-74254	155	18	ile408	ile408	PROPN
bibechana-74254	155	19	and	and	CCONJ
bibechana-74254	155	20	ala410	ala410	NOUN
bibechana-74254	155	21	of	of	ADP
bibechana-74254	155	22	hdac2	hdac2	NOUN
bibechana-74254	155	23	with	with	ADP
bibechana-74254	155	24	leu180	leu180	PROPN
bibechana-74254	155	25	and	and	CCONJ
bibechana-74254	155	26	leu181	leu181	PROPN
bibechana-74254	155	27	of	of	ADP
bibechana-74254	155	28	mta1	mta1	PROPN
bibechana-74254	155	29	in	in	ADP
bibechana-74254	155	30	the	the	DET
bibechana-74254	155	31	rearrangement	rearrangement	NOUN
bibechana-74254	155	32	of	of	ADP
bibechana-74254	155	33	the	the	DET
bibechana-74254	155	34	hdac2	hdac2	NOUN
bibechana-74254	155	35	-	-	PUNCT
bibechana-74254	155	36	mta1	mta1	PROPN
bibechana-74254	155	37	complex	complex	NOUN
bibechana-74254	155	38	.	.	PUNCT
bibechana-74254	156	1	prior	prior	ADJ
bibechana-74254	156	2	theoretical	theoretical	ADJ
bibechana-74254	156	3	and	and	CCONJ
bibechana-74254	156	4	experimental	experimental	ADJ
bibechana-74254	156	5	research	research	NOUN
bibechana-74254	156	6	has	have	AUX
bibechana-74254	156	7	indicated	indicate	VERB
bibechana-74254	156	8	that	that	SCONJ
bibechana-74254	156	9	burying	bury	VERB
bibechana-74254	156	10	1	1	NUM
bibechana-74254	156	11	å2	å2	NOUN
bibechana-74254	156	12	of	of	ADP
bibechana-74254	156	13	the	the	DET
bibechana-74254	156	14	hydrophobic	hydrophobic	NOUN
bibechana-74254	156	15	surface	surface	NOUN
bibechana-74254	156	16	at	at	ADP
bibechana-74254	156	17	the	the	DET
bibechana-74254	156	18	protein	protein	NOUN
bibechana-74254	156	19	-	-	PUNCT
bibechana-74254	156	20	protein	protein	NOUN
bibechana-74254	156	21	interface	interface	NOUN
bibechana-74254	156	22	increases	increase	VERB
bibechana-74254	156	23	the	the	DET
bibechana-74254	156	24	complex	complex	ADJ
bibechana-74254	156	25	stabilization	stabilization	NOUN
bibechana-74254	156	26	free	free	ADJ
bibechana-74254	156	27	energy	energy	NOUN
bibechana-74254	156	28	by	by	ADP
bibechana-74254	156	29	-15	-15	PROPN
bibechana-74254	156	30	±	±	PROPN
bibechana-74254	156	31	1.2	1.2	NUM
bibechana-74254	156	32	cal	cal	NOUN
bibechana-74254	156	33	/	/	SYM
bibechana-74254	156	34	mol	mol	PROPN
bibechana-74254	156	35	.	.	PUNCT
bibechana-74254	157	1	thus	thus	ADV
bibechana-74254	157	2	,	,	PUNCT
bibechana-74254	157	3	in	in	ADP
bibechana-74254	157	4	the	the	DET
bibechana-74254	157	5	case	case	NOUN
bibechana-74254	157	6	of	of	ADP
bibechana-74254	157	7	the	the	DET
bibechana-74254	157	8	hdac2	hdac2	NOUN
bibechana-74254	157	9	-	-	PUNCT
bibechana-74254	157	10	mta1	mta1	PROPN
bibechana-74254	157	11	complex	complex	NOUN
bibechana-74254	157	12	,	,	PUNCT
bibechana-74254	157	13	the	the	DET
bibechana-74254	157	14	hydrophobic	hydrophobic	NOUN
bibechana-74254	157	15	surface	surface	NOUN
bibechana-74254	157	16	area	area	NOUN
bibechana-74254	157	17	at	at	ADP
bibechana-74254	157	18	the	the	DET
bibechana-74254	157	19	hdac2	hdac2	NOUN
bibechana-74254	157	20	-	-	PUNCT
bibechana-74254	157	21	mta1	mta1	PROPN
bibechana-74254	157	22	interface	interface	NOUN
bibechana-74254	157	23	,	,	PUNCT
bibechana-74254	157	24	which	which	PRON
bibechana-74254	157	25	measures	measure	VERB
bibechana-74254	157	26	243.89	243.89	NUM
bibechana-74254	157	27	å2	å2	NOUN
bibechana-74254	157	28	,	,	PUNCT
bibechana-74254	157	29	plays	play	VERB
bibechana-74254	157	30	a	a	DET
bibechana-74254	157	31	significant	significant	ADJ
bibechana-74254	157	32	role	role	NOUN
bibechana-74254	157	33	in	in	ADP
bibechana-74254	157	34	contributing	contribute	VERB
bibechana-74254	157	35	approximately	approximately	ADV
bibechana-74254	157	36	-3.66	-3.66	NUM
bibechana-74254	157	37	kcal	kcal	NOUN
bibechana-74254	157	38	/	/	SYM
bibechana-74254	157	39	mol	mol	NOUN
bibechana-74254	157	40	to	to	ADP
bibechana-74254	157	41	its	its	PRON
bibechana-74254	157	42	stability	stability	NOUN
bibechana-74254	157	43	.	.	PUNCT
bibechana-74254	158	1	this	this	PRON
bibechana-74254	158	2	suggests	suggest	VERB
bibechana-74254	158	3	that	that	SCONJ
bibechana-74254	158	4	hydrophobic	hydrophobic	NOUN
bibechana-74254	158	5	interactions	interaction	NOUN
bibechana-74254	158	6	are	be	AUX
bibechana-74254	158	7	essential	essential	ADJ
bibechana-74254	158	8	in	in	ADP
bibechana-74254	158	9	the	the	DET
bibechana-74254	158	10	formation	formation	NOUN
bibechana-74254	158	11	and	and	CCONJ
bibechana-74254	158	12	stabilization	stabilization	NOUN
bibechana-74254	158	13	of	of	ADP
bibechana-74254	158	14	the	the	DET
bibechana-74254	158	15	hdac2	hdac2	NOUN
bibechana-74254	158	16	–	–	PUNCT
bibechana-74254	158	17	mta1	mta1	NOUN
bibechana-74254	158	18	complex	complex	NOUN
bibechana-74254	158	19	.	.	PUNCT
bibechana-74254	159	1	figure	figure	NOUN
bibechana-74254	159	2	6	6	NUM
bibechana-74254	159	3	:	:	PUNCT
bibechana-74254	159	4	(	(	PUNCT
bibechana-74254	159	5	a	a	X
bibechana-74254	159	6	)	)	PUNCT
bibechana-74254	159	7	contact	contact	NOUN
bibechana-74254	159	8	surface	surface	NOUN
bibechana-74254	159	9	area	area	NOUN
bibechana-74254	159	10	measurements	measurement	VERB
bibechana-74254	159	11	hdac2	hdac2	NOUN
bibechana-74254	159	12	and	and	CCONJ
bibechana-74254	159	13	mta1	mta1	NOUN
bibechana-74254	159	14	in	in	ADP
bibechana-74254	159	15	hdac2	hdac2	NOUN
bibechana-74254	159	16	-	-	PUNCT
bibechana-74254	159	17	mta1	mta1	PROPN
bibechana-74254	159	18	complex	complex	NOUN
bibechana-74254	159	19	,	,	PUNCT
bibechana-74254	159	20	and	and	CCONJ
bibechana-74254	159	21	(	(	PUNCT
bibechana-74254	159	22	b	b	NOUN
bibechana-74254	159	23	)	)	PUNCT
bibechana-74254	159	24	time	time	NOUN
bibechana-74254	159	25	evolution	evolution	NOUN
bibechana-74254	159	26	of	of	ADP
bibechana-74254	159	27	the	the	DET
bibechana-74254	159	28	non	non	ADJ
bibechana-74254	159	29	-	-	ADJ
bibechana-74254	159	30	bonded	bonded	ADJ
bibechana-74254	159	31	interaction	interaction	NOUN
bibechana-74254	159	32	energy	energy	NOUN
bibechana-74254	159	33	in	in	ADP
bibechana-74254	159	34	the	the	DET
bibechana-74254	159	35	hdac2	hdac2	NOUN
bibechana-74254	159	36	-	-	PUNCT
bibechana-74254	159	37	mta1	mta1	PROPN
bibechana-74254	159	38	complex	complex	NOUN
bibechana-74254	159	39	.	.	PUNCT
bibechana-74254	160	1	we	we	PRON
bibechana-74254	160	2	also	also	ADV
bibechana-74254	160	3	analyzed	analyze	VERB
bibechana-74254	160	4	two	two	NUM
bibechana-74254	160	5	interactions	interaction	NOUN
bibechana-74254	160	6	,	,	PUNCT
bibechana-74254	160	7	electrostatic	electrostatic	ADJ
bibechana-74254	160	8	and	and	CCONJ
bibechana-74254	160	9	van	van	PROPN
bibechana-74254	160	10	der	der	NOUN
bibechana-74254	160	11	waals	waal	NOUN
bibechana-74254	160	12	,	,	PUNCT
bibechana-74254	160	13	that	that	PRON
bibechana-74254	160	14	help	help	VERB
bibechana-74254	160	15	to	to	PART
bibechana-74254	160	16	stabilize	stabilize	VERB
bibechana-74254	160	17	hdac2mta1	hdac2mta1	NOUN
bibechana-74254	160	18	complex	complex	ADJ
bibechana-74254	160	19	.	.	PUNCT
bibechana-74254	161	1	electrostatic	electrostatic	ADJ
bibechana-74254	161	2	interactions	interaction	NOUN
bibechana-74254	161	3	are	be	AUX
bibechana-74254	161	4	due	due	ADJ
bibechana-74254	161	5	to	to	ADP
bibechana-74254	161	6	the	the	DET
bibechana-74254	161	7	charged	charge	VERB
bibechana-74254	161	8	residues	residue	NOUN
bibechana-74254	161	9	in	in	ADP
bibechana-74254	161	10	the	the	DET
bibechana-74254	161	11	proteins	protein	NOUN
bibechana-74254	161	12	.	.	PUNCT
bibechana-74254	162	1	our	our	PRON
bibechana-74254	162	2	result	result	NOUN
bibechana-74254	162	3	estimated	estimate	VERB
bibechana-74254	162	4	that	that	SCONJ
bibechana-74254	162	5	these	these	DET
bibechana-74254	162	6	interactions	interaction	NOUN
bibechana-74254	162	7	are	be	AUX
bibechana-74254	162	8	stable	stable	ADJ
bibechana-74254	162	9	after	after	ADP
bibechana-74254	162	10	280	280	NUM
bibechana-74254	162	11	ns	ns	NUM
bibechana-74254	162	12	of	of	ADP
bibechana-74254	162	13	simulation	simulation	NOUN
bibechana-74254	162	14	and	and	CCONJ
bibechana-74254	162	15	its	its	PRON
bibechana-74254	162	16	value	value	NOUN
bibechana-74254	162	17	was	be	AUX
bibechana-74254	162	18	-1220.25	-1220.25	PROPN
bibechana-74254	162	19	±	±	NUM
bibechana-74254	162	20	126.65	126.65	NUM
bibechana-74254	162	21	kcal	kcal	PROPN
bibechana-74254	162	22	/	/	SYM
bibechana-74254	162	23	mol	mol	PROPN
bibechana-74254	162	24	.	.	PUNCT
bibechana-74254	163	1	van	van	PROPN
bibechana-74254	163	2	der	der	PROPN
bibechana-74254	163	3	waals	waal	NOUN
bibechana-74254	163	4	interactions	interaction	NOUN
bibechana-74254	163	5	are	be	AUX
bibechana-74254	163	6	relatively	relatively	ADV
bibechana-74254	163	7	weaker	weak	ADJ
bibechana-74254	163	8	interactions	interaction	NOUN
bibechana-74254	163	9	.	.	PUNCT
bibechana-74254	164	1	these	these	DET
bibechana-74254	164	2	interactions	interaction	NOUN
bibechana-74254	164	3	remained	remain	VERB
bibechana-74254	164	4	stable	stable	ADJ
bibechana-74254	164	5	from	from	ADP
bibechana-74254	164	6	the	the	DET
bibechana-74254	164	7	beginning	beginning	NOUN
bibechana-74254	164	8	to	to	ADP
bibechana-74254	164	9	the	the	DET
bibechana-74254	164	10	end	end	NOUN
bibechana-74254	164	11	of	of	ADP
bibechana-74254	164	12	our	our	PRON
bibechana-74254	164	13	simulation	simulation	NOUN
bibechana-74254	164	14	.	.	PUNCT
bibechana-74254	165	1	the	the	DET
bibechana-74254	165	2	average	average	ADJ
bibechana-74254	165	3	strength	strength	NOUN
bibechana-74254	165	4	of	of	ADP
bibechana-74254	165	5	the	the	DET
bibechana-74254	165	6	van	van	PROPN
bibechana-74254	165	7	der	der	NOUN
bibechana-74254	165	8	waals	waal	NOUN
bibechana-74254	165	9	interactions	interaction	NOUN
bibechana-74254	165	10	was	be	AUX
bibechana-74254	165	11	-237.55	-237.55	PROPN
bibechana-74254	165	12	±	±	NUM
bibechana-74254	165	13	20.53	20.53	NUM
bibechana-74254	165	14	kcal	kcal	PROPN
bibechana-74254	165	15	/	/	SYM
bibechana-74254	165	16	mol	mol	PROPN
bibechana-74254	165	17	.	.	PUNCT
bibechana-74254	166	1	these	these	DET
bibechana-74254	166	2	negative	negative	ADJ
bibechana-74254	166	3	values	value	NOUN
bibechana-74254	166	4	of	of	ADP
bibechana-74254	166	5	both	both	CCONJ
bibechana-74254	166	6	electrostatic	electrostatic	ADJ
bibechana-74254	166	7	and	and	CCONJ
bibechana-74254	166	8	van	van	PROPN
bibechana-74254	166	9	der	der	NOUN
bibechana-74254	166	10	waals	waal	NOUN
bibechana-74254	166	11	interaction	interaction	NOUN
bibechana-74254	166	12	energy	energy	NOUN
bibechana-74254	166	13	is	be	AUX
bibechana-74254	166	14	favorable	favorable	ADJ
bibechana-74254	166	15	for	for	ADP
bibechana-74254	166	16	the	the	DET
bibechana-74254	166	17	interaction	interaction	NOUN
bibechana-74254	166	18	of	of	ADP
bibechana-74254	166	19	hdac2	hdac2	NOUN
bibechana-74254	166	20	-	-	PUNCT
bibechana-74254	166	21	mta1	mta1	PROPN
bibechana-74254	166	22	.	.	PUNCT
bibechana-74254	167	1	both	both	DET
bibechana-74254	167	2	non	non	ADJ
bibechana-74254	167	3	-	-	ADJ
bibechana-74254	167	4	bonded	bonded	ADJ
bibechana-74254	167	5	interaction	interaction	NOUN
bibechana-74254	167	6	energies	energy	NOUN
bibechana-74254	167	7	contribute	contribute	VERB
bibechana-74254	167	8	to	to	ADP
bibechana-74254	167	9	the	the	DET
bibechana-74254	167	10	stable	stable	ADJ
bibechana-74254	167	11	binding	binding	NOUN
bibechana-74254	167	12	of	of	ADP
bibechana-74254	167	13	the	the	DET
bibechana-74254	167	14	hdac2	hdac2	NOUN
bibechana-74254	167	15	–	–	PUNCT
bibechana-74254	167	16	mta1	mta1	NOUN
bibechana-74254	167	17	complex	complex	NOUN
bibechana-74254	167	18	.	.	PUNCT
bibechana-74254	168	1	this	this	DET
bibechana-74254	168	2	observation	observation	NOUN
bibechana-74254	168	3	suggests	suggest	VERB
bibechana-74254	168	4	that	that	SCONJ
bibechana-74254	168	5	hdac2	hdac2	NOUN
bibechana-74254	168	6	and	and	CCONJ
bibechana-74254	168	7	mta1	mta1	PROPN
bibechana-74254	168	8	form	form	VERB
bibechana-74254	168	9	a	a	DET
bibechana-74254	168	10	stable	stable	ADJ
bibechana-74254	168	11	complex	complex	NOUN
bibechana-74254	168	12	through	through	ADP
bibechana-74254	168	13	multiple	multiple	ADJ
bibechana-74254	168	14	non	non	ADJ
bibechana-74254	168	15	-	-	ADJ
bibechana-74254	168	16	covalent	covalent	ADJ
bibechana-74254	168	17	interactions	interaction	NOUN
bibechana-74254	168	18	.	.	PUNCT
bibechana-74254	169	1	3.3.4	3.3.4	NUM
bibechana-74254	169	2	binding	bind	VERB
bibechana-74254	169	3	free	free	ADJ
bibechana-74254	169	4	energy	energy	NOUN
bibechana-74254	169	5	of	of	ADP
bibechana-74254	169	6	the	the	DET
bibechana-74254	169	7	complex	complex	NOUN
bibechana-74254	169	8	in	in	ADP
bibechana-74254	169	9	order	order	NOUN
bibechana-74254	169	10	to	to	PART
bibechana-74254	169	11	determine	determine	VERB
bibechana-74254	169	12	the	the	DET
bibechana-74254	169	13	strength	strength	NOUN
bibechana-74254	169	14	of	of	ADP
bibechana-74254	169	15	the	the	DET
bibechana-74254	169	16	interaction	interaction	NOUN
bibechana-74254	169	17	between	between	ADP
bibechana-74254	169	18	hdac2	hdac2	NOUN
bibechana-74254	169	19	and	and	CCONJ
bibechana-74254	169	20	mta1	mta1	PROPN
bibechana-74254	169	21	,	,	PUNCT
bibechana-74254	169	22	we	we	PRON
bibechana-74254	169	23	employed	employ	VERB
bibechana-74254	169	24	the	the	DET
bibechana-74254	169	25	molecular	molecular	ADJ
bibechana-74254	169	26	mechanics	mechanic	NOUN
bibechana-74254	169	27	with	with	ADP
bibechana-74254	169	28	a	a	DET
bibechana-74254	169	29	generalized	generalize	VERB
bibechana-74254	169	30	born	bear	VERB
bibechana-74254	169	31	and	and	CCONJ
bibechana-74254	169	32	surface	surface	NOUN
bibechana-74254	169	33	area	area	NOUN
bibechana-74254	169	34	solvation	solvation	NOUN
bibechana-74254	169	35	(	(	PUNCT
bibechana-74254	169	36	mm	mm	NOUN
bibechana-74254	169	37	/	/	SYM
bibechana-74254	169	38	gbsa	gbsa	ADJ
bibechana-74254	169	39	)	)	PUNCT
bibechana-74254	169	40	method	method	NOUN
bibechana-74254	169	41	to	to	PART
bibechana-74254	169	42	calculate	calculate	VERB
bibechana-74254	169	43	the	the	DET
bibechana-74254	169	44	binding	bind	VERB
bibechana-74254	169	45	free	free	ADJ
bibechana-74254	169	46	energy	energy	NOUN
bibechana-74254	169	47	of	of	ADP
bibechana-74254	169	48	the	the	DET
bibechana-74254	169	49	complex	complex	NOUN
bibechana-74254	169	50	.	.	PUNCT
bibechana-74254	170	1	we	we	PRON
bibechana-74254	170	2	have	have	AUX
bibechana-74254	170	3	determined	determine	VERB
bibechana-74254	170	4	the	the	DET
bibechana-74254	170	5	binding	bind	VERB
bibechana-74254	170	6	free	free	ADJ
bibechana-74254	170	7	energy	energy	NOUN
bibechana-74254	170	8	of	of	ADP
bibechana-74254	170	9	the	the	DET
bibechana-74254	170	10	hdac2	hdac2	NOUN
bibechana-74254	170	11	–	–	PUNCT
bibechana-74254	170	12	mta1	mta1	NOUN
bibechana-74254	170	13	complex	complex	NOUN
bibechana-74254	170	14	using	use	VERB
bibechana-74254	170	15	the	the	DET
bibechana-74254	170	16	molecular	molecular	ADJ
bibechana-74254	170	17	dynamics	dynamic	NOUN
bibechana-74254	170	18	(	(	PUNCT
bibechana-74254	170	19	md	md	PROPN
bibechana-74254	170	20	)	)	PUNCT
bibechana-74254	170	21	simulation	simulation	NOUN
bibechana-74254	170	22	trajectory	trajectory	NOUN
bibechana-74254	170	23	.	.	PUNCT
bibechana-74254	171	1	the	the	DET
bibechana-74254	171	2	mm	mm	PROPN
bibechana-74254	171	3	/	/	SYM
bibechana-74254	171	4	gbsa	gbsa	ADJ
bibechana-74254	171	5	binding	binding	ADJ
bibechana-74254	171	6	free	free	ADJ
bibechana-74254	171	7	energy	energy	NOUN
bibechana-74254	171	8	of	of	ADP
bibechana-74254	171	9	the	the	DET
bibechana-74254	171	10	hdac2	hdac2	NOUN
bibechana-74254	171	11	–	–	PUNCT
bibechana-74254	171	12	mta1	mta1	NOUN
bibechana-74254	171	13	complex	complex	NOUN
bibechana-74254	171	14	is	be	AUX
bibechana-74254	171	15	-223.14	-223.14	PROPN
bibechana-74254	171	16	±	±	NUM
bibechana-74254	171	17	17.71	17.71	NUM
bibechana-74254	171	18	kcal	kcal	PROPN
bibechana-74254	171	19	/	/	SYM
bibechana-74254	171	20	mol	mol	PROPN
bibechana-74254	171	21	,	,	PUNCT
bibechana-74254	171	22	indicating	indicate	VERB
bibechana-74254	171	23	a	a	DET
bibechana-74254	171	24	substantial	substantial	ADJ
bibechana-74254	171	25	binding	binding	ADJ
bibechana-74254	171	26	free	free	ADJ
bibechana-74254	171	27	energy	energy	NOUN
bibechana-74254	171	28	for	for	ADP
bibechana-74254	171	29	a	a	DET
bibechana-74254	171	30	stable	stable	ADJ
bibechana-74254	171	31	protein	protein	NOUN
bibechana-74254	171	32	–	–	PUNCT
bibechana-74254	171	33	protein	protein	NOUN
bibechana-74254	171	34	complex	complex	NOUN
bibechana-74254	171	35	.	.	PUNCT
bibechana-74254	172	1	4	4	NUM
bibechana-74254	172	2	conclusions	conclusion	NOUN
bibechana-74254	172	3	the	the	DET
bibechana-74254	172	4	hdac	hdac	PROPN
bibechana-74254	172	5	(	(	PUNCT
bibechana-74254	172	6	nurd	nurd	PROPN
bibechana-74254	172	7	)	)	PUNCT
bibechana-74254	172	8	complex	complex	NOUN
bibechana-74254	172	9	with	with	ADP
bibechana-74254	172	10	that	that	PRON
bibechana-74254	172	11	of	of	ADP
bibechana-74254	172	12	mta1	mta1	NOUN
bibechana-74254	172	13	have	have	AUX
bibechana-74254	172	14	indicated	indicate	VERB
bibechana-74254	172	15	a	a	DET
bibechana-74254	172	16	possible	possible	ADJ
bibechana-74254	172	17	function	function	NOUN
bibechana-74254	172	18	of	of	ADP
bibechana-74254	172	19	hdacs	hdac	NOUN
bibechana-74254	172	20	in	in	ADP
bibechana-74254	172	21	tumor	tumor	NOUN
bibechana-74254	172	22	progression	progression	NOUN
bibechana-74254	172	23	.	.	PUNCT
bibechana-74254	173	1	mta1	mta1	NOUN
bibechana-74254	173	2	is	be	AUX
bibechana-74254	173	3	a	a	DET
bibechana-74254	173	4	target	target	NOUN
bibechana-74254	173	5	of	of	ADP
bibechana-74254	173	6	heregulin	heregulin	PROPN
bibechana-74254	173	7	(	(	PUNCT
bibechana-74254	173	8	hrg	hrg	PROPN
bibechana-74254	173	9	)	)	PUNCT
bibechana-74254	173	10	and	and	CCONJ
bibechana-74254	173	11	plays	play	VERB
bibechana-74254	173	12	a	a	DET
bibechana-74254	173	13	significant	significant	ADJ
bibechana-74254	173	14	role	role	NOUN
bibechana-74254	173	15	in	in	ADP
bibechana-74254	173	16	the	the	DET
bibechana-74254	173	17	repression	repression	NOUN
bibechana-74254	173	18	of	of	ADP
bibechana-74254	173	19	estrogen	estrogen	NOUN
bibechana-74254	173	20	receptor	receptor	NOUN
bibechana-74254	173	21	(	(	PUNCT
bibechana-74254	173	22	er)-mediated	er)-mediate	VERB
bibechana-74254	173	23	transcripnarayan	transcripnarayan	ADJ
bibechana-74254	173	24	gautam	gautam	NOUN
bibechana-74254	173	25	and	and	CCONJ
bibechana-74254	173	26	narayan	narayan	PROPN
bibechana-74254	173	27	p.	p.	NOUN
bibechana-74254	173	28	adhikari/	adhikari/	NUM
bibechana-74254	173	29	bibechana	bibechana	NOUN
bibechana-74254	173	30	22	22	NUM
bibechana-74254	173	31	(	(	PUNCT
bibechana-74254	173	32	2025	2025	NUM
bibechana-74254	173	33	)	)	PUNCT
bibechana-74254	173	34	108	108	NUM
bibechana-74254	173	35	-	-	SYM
bibechana-74254	173	36	115	115	NUM
bibechana-74254	173	37	114	114	NUM
bibechana-74254	173	38	tion	tion	NOUN
bibechana-74254	173	39	by	by	ADP
bibechana-74254	173	40	recruiting	recruit	VERB
bibechana-74254	173	41	hdacs	hdac	NOUN
bibechana-74254	173	42	.	.	PUNCT
bibechana-74254	174	1	in	in	ADP
bibechana-74254	174	2	this	this	DET
bibechana-74254	174	3	work	work	NOUN
bibechana-74254	174	4	,	,	PUNCT
bibechana-74254	174	5	we	we	PRON
bibechana-74254	174	6	investigated	investigate	VERB
bibechana-74254	174	7	the	the	DET
bibechana-74254	174	8	molecular	molecular	ADJ
bibechana-74254	174	9	mechanism	mechanism	NOUN
bibechana-74254	174	10	of	of	ADP
bibechana-74254	174	11	complex	complex	ADJ
bibechana-74254	174	12	formation	formation	NOUN
bibechana-74254	174	13	of	of	ADP
bibechana-74254	174	14	hdac2	hdac2	NOUN
bibechana-74254	174	15	with	with	ADP
bibechana-74254	174	16	mta1	mta1	NOUN
bibechana-74254	174	17	protein	protein	NOUN
bibechana-74254	174	18	,	,	PUNCT
bibechana-74254	174	19	using	use	VERB
bibechana-74254	174	20	structure	structure	NOUN
bibechana-74254	174	21	predicting	predict	VERB
bibechana-74254	174	22	tool	tool	NOUN
bibechana-74254	174	23	alphafold2	alphafold2	NOUN
bibechana-74254	174	24	and	and	CCONJ
bibechana-74254	174	25	performed	perform	VERB
bibechana-74254	174	26	md	md	PROPN
bibechana-74254	174	27	simulations	simulation	NOUN
bibechana-74254	174	28	.	.	PUNCT
bibechana-74254	175	1	we	we	PRON
bibechana-74254	175	2	obtained	obtain	VERB
bibechana-74254	175	3	the	the	DET
bibechana-74254	175	4	hdac2	hdac2	NOUN
bibechana-74254	175	5	-	-	PUNCT
bibechana-74254	175	6	mta1	mta1	PROPN
bibechana-74254	175	7	complex	complex	NOUN
bibechana-74254	175	8	from	from	ADP
bibechana-74254	175	9	molecular	molecular	ADJ
bibechana-74254	175	10	modeling	modeling	NOUN
bibechana-74254	175	11	and	and	CCONJ
bibechana-74254	175	12	assessed	assess	VERB
bibechana-74254	175	13	its	its	PRON
bibechana-74254	175	14	stability	stability	NOUN
bibechana-74254	175	15	using	use	VERB
bibechana-74254	175	16	md	md	PROPN
bibechana-74254	175	17	simulations	simulation	NOUN
bibechana-74254	175	18	.	.	PUNCT
bibechana-74254	176	1	our	our	PRON
bibechana-74254	176	2	results	result	NOUN
bibechana-74254	176	3	show	show	VERB
bibechana-74254	176	4	that	that	SCONJ
bibechana-74254	176	5	hdac2	hdac2	NOUN
bibechana-74254	176	6	interacts	interact	VERB
bibechana-74254	176	7	with	with	ADP
bibechana-74254	176	8	mta1	mta1	NOUN
bibechana-74254	176	9	through	through	ADP
bibechana-74254	176	10	elm2sant	elm2sant	PROPN
bibechana-74254	176	11	domains	domain	NOUN
bibechana-74254	176	12	as	as	ADP
bibechana-74254	176	13	in	in	ADP
bibechana-74254	176	14	hdac1	hdac1	NOUN
bibechana-74254	176	15	-	-	PUNCT
bibechana-74254	176	16	mta1	mta1	NOUN
bibechana-74254	176	17	interaction	interaction	NOUN
bibechana-74254	176	18	.	.	PUNCT
bibechana-74254	177	1	several	several	ADJ
bibechana-74254	177	2	hydrogen	hydrogen	NOUN
bibechana-74254	177	3	bonding	bonding	NOUN
bibechana-74254	177	4	interactions	interaction	NOUN
bibechana-74254	177	5	between	between	ADP
bibechana-74254	177	6	the	the	DET
bibechana-74254	177	7	residues	residue	NOUN
bibechana-74254	177	8	at	at	ADP
bibechana-74254	177	9	the	the	DET
bibechana-74254	177	10	binding	bind	VERB
bibechana-74254	177	11	interface	interface	NOUN
bibechana-74254	177	12	are	be	AUX
bibechana-74254	177	13	also	also	ADV
bibechana-74254	177	14	involved	involve	VERB
bibechana-74254	177	15	in	in	ADP
bibechana-74254	177	16	the	the	DET
bibechana-74254	177	17	binding	binding	NOUN
bibechana-74254	177	18	of	of	ADP
bibechana-74254	177	19	hdac2	hdac2	NOUN
bibechana-74254	177	20	and	and	CCONJ
bibechana-74254	177	21	mta1	mta1	PROPN
bibechana-74254	177	22	.	.	PUNCT
bibechana-74254	178	1	in	in	ADP
bibechana-74254	178	2	addition	addition	NOUN
bibechana-74254	178	3	to	to	ADP
bibechana-74254	178	4	hydrogen	hydrogen	NOUN
bibechana-74254	178	5	bonding	bonding	NOUN
bibechana-74254	178	6	,	,	PUNCT
bibechana-74254	178	7	salt	salt	NOUN
bibechana-74254	178	8	bridges	bridge	NOUN
bibechana-74254	178	9	between	between	ADP
bibechana-74254	178	10	the	the	DET
bibechana-74254	178	11	interfacial	interfacial	ADJ
bibechana-74254	178	12	charged	charge	VERB
bibechana-74254	178	13	residues	residue	NOUN
bibechana-74254	178	14	are	be	AUX
bibechana-74254	178	15	the	the	DET
bibechana-74254	178	16	also	also	ADV
bibechana-74254	178	17	the	the	DET
bibechana-74254	178	18	major	major	ADJ
bibechana-74254	178	19	interactions	interaction	NOUN
bibechana-74254	178	20	involved	involve	VERB
bibechana-74254	178	21	in	in	ADP
bibechana-74254	178	22	the	the	DET
bibechana-74254	178	23	binding	binding	NOUN
bibechana-74254	178	24	.	.	PUNCT
bibechana-74254	179	1	furthermore	furthermore	ADV
bibechana-74254	179	2	,	,	PUNCT
bibechana-74254	179	3	hydrophobic	hydrophobic	NOUN
bibechana-74254	179	4	interactions	interaction	NOUN
bibechana-74254	179	5	play	play	VERB
bibechana-74254	179	6	a	a	DET
bibechana-74254	179	7	significant	significant	ADJ
bibechana-74254	179	8	role	role	NOUN
bibechana-74254	179	9	in	in	ADP
bibechana-74254	179	10	forming	form	VERB
bibechana-74254	179	11	and	and	CCONJ
bibechana-74254	179	12	stabilizing	stabilize	VERB
bibechana-74254	179	13	the	the	DET
bibechana-74254	179	14	hdac2	hdac2	NOUN
bibechana-74254	179	15	-	-	PUNCT
bibechana-74254	179	16	mta1	mta1	PROPN
bibechana-74254	179	17	complex	complex	NOUN
bibechana-74254	179	18	.	.	PUNCT
bibechana-74254	180	1	our	our	PRON
bibechana-74254	180	2	results	result	NOUN
bibechana-74254	180	3	reveal	reveal	VERB
bibechana-74254	180	4	that	that	SCONJ
bibechana-74254	180	5	hdac2	hdac2	NOUN
bibechana-74254	180	6	strongly	strongly	ADV
bibechana-74254	180	7	wrapped	wrap	VERB
bibechana-74254	180	8	by	by	ADP
bibechana-74254	180	9	mta1	mta1	NOUN
bibechana-74254	180	10	,	,	PUNCT
bibechana-74254	180	11	forming	form	VERB
bibechana-74254	180	12	a	a	DET
bibechana-74254	180	13	stable	stable	ADJ
bibechana-74254	180	14	complex	complex	NOUN
bibechana-74254	180	15	via	via	ADP
bibechana-74254	180	16	different	different	ADJ
bibechana-74254	180	17	interactions	interaction	NOUN
bibechana-74254	180	18	.	.	PUNCT
bibechana-74254	181	1	our	our	PRON
bibechana-74254	181	2	first	first	ADJ
bibechana-74254	181	3	structural	structural	ADJ
bibechana-74254	181	4	characterization	characterization	NOUN
bibechana-74254	181	5	of	of	ADP
bibechana-74254	181	6	the	the	DET
bibechana-74254	181	7	hdac2	hdac2	NOUN
bibechana-74254	181	8	–	–	PUNCT
bibechana-74254	181	9	mta1	mta1	NOUN
bibechana-74254	181	10	complex	complex	NOUN
bibechana-74254	181	11	outlines	outline	VERB
bibechana-74254	181	12	the	the	DET
bibechana-74254	181	13	molecular	molecular	ADJ
bibechana-74254	181	14	basis	basis	NOUN
bibechana-74254	181	15	of	of	ADP
bibechana-74254	181	16	the	the	DET
bibechana-74254	181	17	interaction	interaction	NOUN
bibechana-74254	181	18	of	of	ADP
bibechana-74254	181	19	hdac2	hdac2	NOUN
bibechana-74254	181	20	with	with	ADP
bibechana-74254	181	21	mta1	mta1	PROPN
bibechana-74254	181	22	,	,	PUNCT
bibechana-74254	181	23	which	which	PRON
bibechana-74254	181	24	offers	offer	VERB
bibechana-74254	181	25	valuable	valuable	ADJ
bibechana-74254	181	26	insights	insight	NOUN
bibechana-74254	181	27	into	into	ADP
bibechana-74254	181	28	the	the	DET
bibechana-74254	181	29	recruitment	recruitment	NOUN
bibechana-74254	181	30	mechanism	mechanism	NOUN
bibechana-74254	181	31	of	of	ADP
bibechana-74254	181	32	the	the	DET
bibechana-74254	181	33	hdac	hdac	NOUN
bibechana-74254	181	34	complex	complex	NOUN
bibechana-74254	181	35	for	for	ADP
bibechana-74254	181	36	the	the	DET
bibechana-74254	181	37	transcription	transcription	NOUN
bibechana-74254	181	38	repression	repression	NOUN
bibechana-74254	181	39	mediated	mediate	VERB
bibechana-74254	181	40	by	by	ADP
bibechana-74254	181	41	mta1	mta1	PROPN
bibechana-74254	181	42	.	.	PUNCT
bibechana-74254	182	1	disclosure	disclosure	NOUN
bibechana-74254	182	2	statement	statement	NOUN
bibechana-74254	182	3	there	there	PRON
bibechana-74254	182	4	are	be	VERB
bibechana-74254	182	5	no	no	DET
bibechana-74254	182	6	conflicts	conflict	NOUN
bibechana-74254	182	7	to	to	PART
bibechana-74254	182	8	declare	declare	VERB
bibechana-74254	182	9	.	.	PUNCT
bibechana-74254	183	1	author	author	NOUN
bibechana-74254	183	2	contributions	contribution	NOUN
bibechana-74254	183	3	npa	npa	PROPN
bibechana-74254	183	4	supervised	supervise	VERB
bibechana-74254	183	5	the	the	DET
bibechana-74254	183	6	project	project	NOUN
bibechana-74254	183	7	.	.	PUNCT
bibechana-74254	184	1	ng	ng	PROPN
bibechana-74254	184	2	performed	perform	VERB
bibechana-74254	184	3	the	the	DET
bibechana-74254	184	4	md	md	PROPN
bibechana-74254	184	5	simulations	simulation	NOUN
bibechana-74254	184	6	and	and	CCONJ
bibechana-74254	184	7	analyzed	analyze	VERB
bibechana-74254	184	8	the	the	DET
bibechana-74254	184	9	data	datum	NOUN
bibechana-74254	184	10	.	.	PUNCT
bibechana-74254	185	1	ng	ng	PROPN
bibechana-74254	185	2	and	and	CCONJ
bibechana-74254	185	3	npa	npa	PROPN
bibechana-74254	185	4	contributed	contribute	VERB
bibechana-74254	185	5	to	to	ADP
bibechana-74254	185	6	the	the	DET
bibechana-74254	185	7	data	datum	NOUN
bibechana-74254	185	8	analysis	analysis	NOUN
bibechana-74254	185	9	and	and	CCONJ
bibechana-74254	185	10	interpretation	interpretation	NOUN
bibechana-74254	185	11	.	.	PUNCT
bibechana-74254	186	1	ng	ng	PROPN
bibechana-74254	186	2	wrote	write	VERB
bibechana-74254	186	3	the	the	DET
bibechana-74254	186	4	manuscript	manuscript	NOUN
bibechana-74254	186	5	npa	npa	PROPN
bibechana-74254	186	6	contributed	contribute	VERB
bibechana-74254	186	7	to	to	PART
bibechana-74254	186	8	manuscript	manuscript	VERB
bibechana-74254	186	9	editing	editing	NOUN
bibechana-74254	186	10	.	.	PUNCT
bibechana-74254	187	1	references	reference	NOUN
bibechana-74254	187	2	[	[	X
bibechana-74254	187	3	1	1	NUM
bibechana-74254	187	4	]	]	PUNCT
bibechana-74254	187	5	a.	a.	NOUN
bibechana-74254	187	6	mazumdar	mazumdar	NOUN
bibechana-74254	187	7	et	et	PROPN
bibechana-74254	187	8	al	al	PROPN
bibechana-74254	187	9	.	.	PUNCT
bibechana-74254	188	1	transcriptional	transcriptional	ADJ
bibechana-74254	188	2	repression	repression	NOUN
bibechana-74254	188	3	of	of	ADP
bibechana-74254	188	4	oestrogen	oestrogen	NOUN
bibechana-74254	188	5	receptor	receptor	NOUN
bibechana-74254	188	6	by	by	ADP
bibechana-74254	188	7	metastasis	metastasis	NOUN
bibechana-74254	188	8	-	-	PUNCT
bibechana-74254	188	9	associated	associate	VERB
bibechana-74254	188	10	protein	protein	NOUN
bibechana-74254	188	11	1	1	NUM
bibechana-74254	188	12	corepressor	corepressor	NOUN
bibechana-74254	188	13	.	.	PUNCT
bibechana-74254	189	1	3(1):30–37	3(1):30–37	NUM
bibechana-74254	189	2	,	,	PUNCT
bibechana-74254	189	3	2001	2001	NUM
bibechana-74254	189	4	.	.	PUNCT
bibechana-74254	190	1	[	[	X
bibechana-74254	190	2	2	2	NUM
bibechana-74254	190	3	]	]	X
bibechana-74254	190	4	d.	d.	PROPN
bibechana-74254	190	5	hanahan	hanahan	PROPN
bibechana-74254	190	6	and	and	CCONJ
bibechana-74254	190	7	r.a	r.a	PROPN
bibechana-74254	190	8	.	.	PROPN
bibechana-74254	190	9	weinberg	weinberg	PROPN
bibechana-74254	190	10	.	.	PUNCT
bibechana-74254	191	1	the	the	DET
bibechana-74254	191	2	hallmarks	hallmark	NOUN
bibechana-74254	191	3	of	of	ADP
bibechana-74254	191	4	cancer	cancer	NOUN
bibechana-74254	191	5	.	.	PUNCT
bibechana-74254	192	1	100(1):57–70	100(1):57–70	NUM
bibechana-74254	192	2	,	,	PUNCT
bibechana-74254	192	3	2000	2000	NUM
bibechana-74254	192	4	.	.	PUNCT
bibechana-74254	193	1	[	[	X
bibechana-74254	193	2	3	3	NUM
bibechana-74254	193	3	]	]	X
bibechana-74254	193	4	n.	n.	PROPN
bibechana-74254	193	5	sen	sen	PROPN
bibechana-74254	193	6	et	et	PROPN
bibechana-74254	193	7	al	al	PROPN
bibechana-74254	193	8	.	.	PROPN
bibechana-74254	194	1	role	role	NOUN
bibechana-74254	194	2	of	of	ADP
bibechana-74254	194	3	mta1	mta1	NOUN
bibechana-74254	194	4	in	in	ADP
bibechana-74254	194	5	cancer	cancer	NOUN
bibechana-74254	194	6	progression	progression	NOUN
bibechana-74254	194	7	and	and	CCONJ
bibechana-74254	194	8	metastasis	metastasis	NOUN
bibechana-74254	194	9	.	.	PUNCT
bibechana-74254	195	1	33:879–889	33:879–889	NUM
bibechana-74254	195	2	,	,	PUNCT
bibechana-74254	195	3	2014	2014	NUM
bibechana-74254	195	4	.	.	PUNCT
bibechana-74254	196	1	[	[	X
bibechana-74254	196	2	4	4	NUM
bibechana-74254	196	3	]	]	X
bibechana-74254	196	4	p.a	p.a	PROPN
bibechana-74254	196	5	.	.	PROPN
bibechana-74254	196	6	marks	marks	PROPN
bibechana-74254	196	7	et	et	PROPN
bibechana-74254	196	8	al	al	PROPN
bibechana-74254	196	9	.	.	PUNCT
bibechana-74254	197	1	histone	histone	NOUN
bibechana-74254	197	2	deacetylases	deacetylase	NOUN
bibechana-74254	197	3	and	and	CCONJ
bibechana-74254	197	4	cancer	cancer	NOUN
bibechana-74254	197	5	:	:	PUNCT
bibechana-74254	197	6	causes	cause	NOUN
bibechana-74254	197	7	and	and	CCONJ
bibechana-74254	197	8	therapies	therapy	NOUN
bibechana-74254	197	9	.	.	PUNCT
bibechana-74254	198	1	1(3):194–202	1(3):194–202	NUM
bibechana-74254	198	2	,	,	PUNCT
bibechana-74254	198	3	2001	2001	NUM
bibechana-74254	198	4	.	.	PUNCT
bibechana-74254	199	1	[	[	X
bibechana-74254	199	2	5	5	X
bibechana-74254	199	3	]	]	PUNCT
bibechana-74254	199	4	b.	b.	NOUN
bibechana-74254	199	5	weinhold	weinhold	PROPN
bibechana-74254	199	6	.	.	PUNCT
bibechana-74254	200	1	epigenetics	epigenetic	NOUN
bibechana-74254	200	2	:	:	PUNCT
bibechana-74254	200	3	the	the	DET
bibechana-74254	200	4	science	science	NOUN
bibechana-74254	200	5	of	of	ADP
bibechana-74254	200	6	change	change	NOUN
bibechana-74254	200	7	.	.	PUNCT
bibechana-74254	201	1	national	national	PROPN
bibechana-74254	201	2	institute	institute	PROPN
bibechana-74254	201	3	of	of	ADP
bibechana-74254	201	4	environmental	environmental	PROPN
bibechana-74254	201	5	health	health	NOUN
bibechana-74254	201	6	sciences	science	NOUN
bibechana-74254	201	7	,	,	PUNCT
bibechana-74254	201	8	2006	2006	NUM
bibechana-74254	201	9	.	.	PUNCT
bibechana-74254	202	1	[	[	X
bibechana-74254	202	2	6	6	NUM
bibechana-74254	202	3	]	]	PUNCT
bibechana-74254	202	4	i.	i.	NOUN
bibechana-74254	202	5	gregoretti	gregoretti	PROPN
bibechana-74254	202	6	,	,	PUNCT
bibechana-74254	202	7	y.-m	y.-m	PROPN
bibechana-74254	202	8	.	.	PUNCT
bibechana-74254	202	9	lee	lee	PROPN
bibechana-74254	202	10	,	,	PUNCT
bibechana-74254	202	11	and	and	CCONJ
bibechana-74254	202	12	h.v	h.v	PROPN
bibechana-74254	202	13	.	.	PROPN
bibechana-74254	202	14	goodson	goodson	PROPN
bibechana-74254	202	15	.	.	PUNCT
bibechana-74254	203	1	molecular	molecular	ADJ
bibechana-74254	203	2	evolution	evolution	NOUN
bibechana-74254	203	3	of	of	ADP
bibechana-74254	203	4	the	the	DET
bibechana-74254	203	5	histone	histone	NOUN
bibechana-74254	203	6	deacetylase	deacetylase	PROPN
bibechana-74254	203	7	family	family	NOUN
bibechana-74254	203	8	:	:	PUNCT
bibechana-74254	203	9	functional	functional	ADJ
bibechana-74254	203	10	implications	implication	NOUN
bibechana-74254	203	11	of	of	ADP
bibechana-74254	203	12	phylogenetic	phylogenetic	ADJ
bibechana-74254	203	13	analysis	analysis	NOUN
bibechana-74254	203	14	.	.	PUNCT
bibechana-74254	204	1	338(1):17–31	338(1):17–31	NOUN
bibechana-74254	204	2	,	,	PUNCT
bibechana-74254	204	3	2004	2004	NUM
bibechana-74254	204	4	.	.	PUNCT
bibechana-74254	205	1	[	[	X
bibechana-74254	205	2	7	7	X
bibechana-74254	205	3	]	]	X
bibechana-74254	205	4	g.	g.	PROPN
bibechana-74254	205	5	brosch	brosch	PROPN
bibechana-74254	205	6	,	,	PUNCT
bibechana-74254	205	7	p.	p.	NOUN
bibechana-74254	205	8	loidl	loidl	NOUN
bibechana-74254	205	9	,	,	PUNCT
bibechana-74254	205	10	and	and	CCONJ
bibechana-74254	205	11	s.	s.	PROPN
bibechana-74254	205	12	graessle	graessle	PROPN
bibechana-74254	205	13	.	.	PUNCT
bibechana-74254	206	1	histone	histone	NOUN
bibechana-74254	206	2	modifications	modification	NOUN
bibechana-74254	206	3	and	and	CCONJ
bibechana-74254	206	4	chromatin	chromatin	NOUN
bibechana-74254	206	5	dynamics	dynamic	NOUN
bibechana-74254	206	6	:	:	PUNCT
bibechana-74254	206	7	a	a	DET
bibechana-74254	206	8	focus	focus	NOUN
bibechana-74254	206	9	on	on	ADP
bibechana-74254	206	10	filamentous	filamentous	ADJ
bibechana-74254	206	11	fungi	fungus	NOUN
bibechana-74254	206	12	.	.	PUNCT
bibechana-74254	207	1	32(3):409–439	32(3):409–439	NUM
bibechana-74254	207	2	,	,	PUNCT
bibechana-74254	207	3	2008	2008	NUM
bibechana-74254	207	4	.	.	PUNCT
bibechana-74254	208	1	[	[	X
bibechana-74254	208	2	8	8	NUM
bibechana-74254	208	3	]	]	PUNCT
bibechana-74254	208	4	p.	p.	NOUN
bibechana-74254	208	5	gediya	gediya	PROPN
bibechana-74254	208	6	et	et	PROPN
bibechana-74254	208	7	al	al	PROPN
bibechana-74254	208	8	.	.	PUNCT
bibechana-74254	208	9	histone	histone	PROPN
bibechana-74254	208	10	deacetylase	deacetylase	VERB
bibechana-74254	208	11	2	2	NUM
bibechana-74254	208	12	:	:	PUNCT
bibechana-74254	208	13	a	a	DET
bibechana-74254	208	14	potential	potential	ADJ
bibechana-74254	208	15	therapeutic	therapeutic	ADJ
bibechana-74254	208	16	target	target	NOUN
bibechana-74254	208	17	for	for	ADP
bibechana-74254	208	18	cancer	cancer	NOUN
bibechana-74254	208	19	and	and	CCONJ
bibechana-74254	208	20	neurodegenerative	neurodegenerative	ADJ
bibechana-74254	208	21	disorders	disorder	NOUN
bibechana-74254	208	22	.	.	PUNCT
bibechana-74254	209	1	216:113332	216:113332	X
bibechana-74254	209	2	,	,	PUNCT
bibechana-74254	209	3	2021	2021	NUM
bibechana-74254	209	4	.	.	PUNCT
bibechana-74254	210	1	[	[	X
bibechana-74254	210	2	9	9	NUM
bibechana-74254	210	3	]	]	PUNCT
bibechana-74254	210	4	z.-l	z.-l	NOUN
bibechana-74254	210	5	.	.	PUNCT
bibechana-74254	211	1	yuan	yuan	NOUN
bibechana-74254	211	2	et	et	PROPN
bibechana-74254	211	3	al	al	PROPN
bibechana-74254	211	4	.	.	PUNCT
bibechana-74254	212	1	stat3	stat3	NOUN
bibechana-74254	212	2	dimerization	dimerization	NOUN
bibechana-74254	212	3	regulated	regulate	VERB
bibechana-74254	212	4	by	by	ADP
bibechana-74254	212	5	reversible	reversible	ADJ
bibechana-74254	212	6	acetylation	acetylation	NOUN
bibechana-74254	212	7	of	of	ADP
bibechana-74254	212	8	a	a	DET
bibechana-74254	212	9	single	single	ADJ
bibechana-74254	212	10	lysine	lysine	NOUN
bibechana-74254	212	11	residue	residue	NOUN
bibechana-74254	212	12	.	.	PUNCT
bibechana-74254	213	1	307(5707):269–273	307(5707):269–273	NUM
bibechana-74254	213	2	,	,	PUNCT
bibechana-74254	213	3	2005	2005	NUM
bibechana-74254	213	4	.	.	PUNCT
bibechana-74254	214	1	[	[	X
bibechana-74254	214	2	10	10	NUM
bibechana-74254	214	3	]	]	X
bibechana-74254	214	4	h.	h.	PROPN
bibechana-74254	214	5	kook	kook	PROPN
bibechana-74254	214	6	et	et	PROPN
bibechana-74254	214	7	al	al	PROPN
bibechana-74254	214	8	.	.	PUNCT
bibechana-74254	214	9	cardiac	cardiac	ADJ
bibechana-74254	214	10	hypertrophy	hypertrophy	NOUN
bibechana-74254	214	11	and	and	CCONJ
bibechana-74254	214	12	histone	histone	NOUN
bibechana-74254	214	13	deacetylase	deacetylase	NOUN
bibechana-74254	214	14	–	–	PUNCT
bibechana-74254	214	15	dependent	dependent	ADJ
bibechana-74254	214	16	transcriptional	transcriptional	ADJ
bibechana-74254	214	17	repression	repression	NOUN
bibechana-74254	214	18	mediated	mediate	VERB
bibechana-74254	214	19	by	by	ADP
bibechana-74254	214	20	the	the	DET
bibechana-74254	214	21	atypical	atypical	ADJ
bibechana-74254	214	22	homeodomain	homeodomain	NOUN
bibechana-74254	214	23	protein	protein	NOUN
bibechana-74254	214	24	hop	hop	NOUN
bibechana-74254	214	25	.	.	PUNCT
bibechana-74254	215	1	112(6):863–871	112(6):863–871	NUM
bibechana-74254	215	2	,	,	PUNCT
bibechana-74254	215	3	2003	2003	NUM
bibechana-74254	215	4	.	.	PUNCT
bibechana-74254	216	1	[	[	X
bibechana-74254	216	2	11	11	NUM
bibechana-74254	216	3	]	]	PUNCT
bibechana-74254	216	4	a.	a.	PROPN
bibechana-74254	216	5	ito	ito	PROPN
bibechana-74254	216	6	et	et	PROPN
bibechana-74254	216	7	al	al	PROPN
bibechana-74254	216	8	.	.	PUNCT
bibechana-74254	216	9	mdm2	mdm2	PROPN
bibechana-74254	216	10	–	–	PUNCT
bibechana-74254	216	11	hdac1	hdac1	NOUN
bibechana-74254	216	12	-	-	PUNCT
bibechana-74254	216	13	mediated	mediate	VERB
bibechana-74254	216	14	deacetylation	deacetylation	NOUN
bibechana-74254	216	15	of	of	ADP
bibechana-74254	216	16	p53	p53	NOUN
bibechana-74254	216	17	is	be	AUX
bibechana-74254	216	18	required	require	VERB
bibechana-74254	216	19	for	for	ADP
bibechana-74254	216	20	its	its	PRON
bibechana-74254	216	21	degradation	degradation	NOUN
bibechana-74254	216	22	.	.	PUNCT
bibechana-74254	217	1	2002	2002	NUM
bibechana-74254	217	2	.	.	PUNCT
bibechana-74254	218	1	[	[	X
bibechana-74254	218	2	12	12	NUM
bibechana-74254	218	3	]	]	PUNCT
bibechana-74254	218	4	j.	j.	PROPN
bibechana-74254	218	5	luo	luo	PROPN
bibechana-74254	218	6	et	et	PROPN
bibechana-74254	218	7	al	al	PROPN
bibechana-74254	218	8	.	.	PUNCT
bibechana-74254	218	9	acetylation	acetylation	NOUN
bibechana-74254	218	10	of	of	ADP
bibechana-74254	218	11	p53	p53	NOUN
bibechana-74254	218	12	augments	augment	VERB
bibechana-74254	218	13	its	its	PRON
bibechana-74254	218	14	site	site	NOUN
bibechana-74254	218	15	-	-	PUNCT
bibechana-74254	218	16	specific	specific	ADJ
bibechana-74254	218	17	dna	dna	NOUN
bibechana-74254	218	18	binding	bind	VERB
bibechana-74254	218	19	both	both	CCONJ
bibechana-74254	218	20	in	in	ADP
bibechana-74254	218	21	vitro	vitro	X
bibechana-74254	218	22	and	and	CCONJ
bibechana-74254	218	23	in	in	ADP
bibechana-74254	218	24	vivo	vivo	NOUN
bibechana-74254	218	25	.	.	PUNCT
bibechana-74254	219	1	101(8):2259–2264	101(8):2259–2264	NUM
bibechana-74254	219	2	,	,	PUNCT
bibechana-74254	219	3	2004	2004	NUM
bibechana-74254	219	4	.	.	PUNCT
bibechana-74254	220	1	[	[	X
bibechana-74254	220	2	13	13	NUM
bibechana-74254	220	3	]	]	X
bibechana-74254	220	4	g.	g.	NOUN
bibechana-74254	220	5	marzio	marzio	VERB
bibechana-74254	220	6	et	et	PROPN
bibechana-74254	220	7	al	al	PROPN
bibechana-74254	220	8	.	.	PUNCT
bibechana-74254	221	1	e2f	e2f	DET
bibechana-74254	221	2	family	family	NOUN
bibechana-74254	221	3	members	member	NOUN
bibechana-74254	221	4	are	be	AUX
bibechana-74254	221	5	differentially	differentially	ADV
bibechana-74254	221	6	regulated	regulate	VERB
bibechana-74254	221	7	by	by	ADP
bibechana-74254	221	8	reversible	reversible	ADJ
bibechana-74254	221	9	acetylation	acetylation	NOUN
bibechana-74254	221	10	.	.	PUNCT
bibechana-74254	222	1	275(15):10887–10892	275(15):10887–10892	NUM
bibechana-74254	222	2	,	,	PUNCT
bibechana-74254	222	3	2000	2000	NUM
bibechana-74254	222	4	.	.	PUNCT
bibechana-74254	223	1	[	[	X
bibechana-74254	223	2	14	14	NUM
bibechana-74254	223	3	]	]	X
bibechana-74254	223	4	n.	n.	NOUN
bibechana-74254	223	5	sengupta	sengupta	PROPN
bibechana-74254	223	6	and	and	CCONJ
bibechana-74254	223	7	e.	e.	PROPN
bibechana-74254	223	8	seto	seto	PROPN
bibechana-74254	223	9	.	.	PUNCT
bibechana-74254	224	1	regulation	regulation	NOUN
bibechana-74254	224	2	of	of	ADP
bibechana-74254	224	3	histone	histone	NOUN
bibechana-74254	224	4	deacetylase	deacetylase	NOUN
bibechana-74254	224	5	activities	activity	NOUN
bibechana-74254	224	6	.	.	PUNCT
bibechana-74254	225	1	93(1):57–67	93(1):57–67	NUM
bibechana-74254	225	2	,	,	PUNCT
bibechana-74254	225	3	2004	2004	NUM
bibechana-74254	225	4	.	.	PUNCT
bibechana-74254	226	1	[	[	X
bibechana-74254	226	2	15	15	NUM
bibechana-74254	226	3	]	]	X
bibechana-74254	226	4	j.	j.	PROPN
bibechana-74254	226	5	jaworska	jaworska	PROPN
bibechana-74254	226	6	,	,	PUNCT
bibechana-74254	226	7	m.	m.	NOUN
bibechana-74254	226	8	ziemka	ziemka	PROPN
bibechana-74254	226	9	-	-	PUNCT
bibechana-74254	226	10	nalecz	nalecz	PROPN
bibechana-74254	226	11	,	,	PUNCT
bibechana-74254	226	12	and	and	CCONJ
bibechana-74254	226	13	t.	t.	PROPN
bibechana-74254	226	14	zalewska	zalewska	PROPN
bibechana-74254	226	15	.	.	PUNCT
bibechana-74254	227	1	histone	histone	NOUN
bibechana-74254	227	2	deacetylases	deacetylase	NOUN
bibechana-74254	227	3	1	1	NUM
bibechana-74254	227	4	and	and	CCONJ
bibechana-74254	227	5	2	2	NUM
bibechana-74254	227	6	are	be	AUX
bibechana-74254	227	7	required	require	VERB
bibechana-74254	227	8	for	for	ADP
bibechana-74254	227	9	brain	brain	NOUN
bibechana-74254	227	10	development	development	NOUN
bibechana-74254	227	11	.	.	PUNCT
bibechana-74254	228	1	59(4	59(4	NUM
bibechana-74254	228	2	-	-	SYM
bibechana-74254	228	3	6):171–177	6):171–177	NUM
bibechana-74254	228	4	,	,	PUNCT
bibechana-74254	228	5	2015	2015	NUM
bibechana-74254	228	6	.	.	PUNCT
bibechana-74254	229	1	[	[	X
bibechana-74254	229	2	16	16	NUM
bibechana-74254	229	3	]	]	X
bibechana-74254	229	4	r.l	r.l	PROPN
bibechana-74254	229	5	.	.	PROPN
bibechana-74254	229	6	montgomery	montgomery	PROPN
bibechana-74254	229	7	et	et	PROPN
bibechana-74254	229	8	al	al	PROPN
bibechana-74254	229	9	.	.	PUNCT
bibechana-74254	230	1	histone	histone	NOUN
bibechana-74254	230	2	deacetylases	deacetylase	NOUN
bibechana-74254	230	3	1	1	NUM
bibechana-74254	230	4	and	and	CCONJ
bibechana-74254	230	5	2	2	NUM
bibechana-74254	230	6	redundantly	redundantly	ADV
bibechana-74254	230	7	regulate	regulate	VERB
bibechana-74254	230	8	cardiac	cardiac	ADJ
bibechana-74254	230	9	morphogenesis	morphogenesis	NOUN
bibechana-74254	230	10	,	,	PUNCT
bibechana-74254	230	11	growth	growth	NOUN
bibechana-74254	230	12	,	,	PUNCT
bibechana-74254	230	13	and	and	CCONJ
bibechana-74254	230	14	contractility	contractility	NOUN
bibechana-74254	230	15	.	.	PUNCT
bibechana-74254	231	1	21(14):1790–1802	21(14):1790–1802	NUM
bibechana-74254	231	2	,	,	PUNCT
bibechana-74254	231	3	2007	2007	NUM
bibechana-74254	231	4	.	.	PUNCT
bibechana-74254	232	1	[	[	X
bibechana-74254	232	2	17	17	NUM
bibechana-74254	232	3	]	]	X
bibechana-74254	232	4	n.j	n.j	PROPN
bibechana-74254	232	5	.	.	PROPN
bibechana-74254	232	6	bowen	bowen	PROPN
bibechana-74254	232	7	et	et	PROPN
bibechana-74254	232	8	al	al	PROPN
bibechana-74254	232	9	.	.	PUNCT
bibechana-74254	232	10	mi-2	mi-2	PROPN
bibechana-74254	232	11	/	/	SYM
bibechana-74254	232	12	nurd	nurd	PROPN
bibechana-74254	232	13	:	:	PUNCT
bibechana-74254	232	14	multiple	multiple	ADJ
bibechana-74254	232	15	complexes	complex	NOUN
bibechana-74254	232	16	for	for	ADP
bibechana-74254	232	17	many	many	ADJ
bibechana-74254	232	18	purposes	purpose	NOUN
bibechana-74254	232	19	.	.	PUNCT
bibechana-74254	233	1	1677(1	1677(1	X
bibechana-74254	233	2	-	-	SYM
bibechana-74254	233	3	3):52–57	3):52–57	NUM
bibechana-74254	233	4	,	,	PUNCT
bibechana-74254	233	5	2004	2004	NUM
bibechana-74254	233	6	.	.	PUNCT
bibechana-74254	234	1	[	[	X
bibechana-74254	234	2	18	18	NUM
bibechana-74254	234	3	]	]	PUNCT
bibechana-74254	234	4	b.	b.	NOUN
bibechana-74254	234	5	manavathi	manavathi	PROPN
bibechana-74254	234	6	and	and	CCONJ
bibechana-74254	234	7	r.	r.	PROPN
bibechana-74254	234	8	kumar	kumar	PROPN
bibechana-74254	234	9	.	.	PUNCT
bibechana-74254	235	1	metastasis	metastasis	NOUN
bibechana-74254	235	2	tumor	tumor	NOUN
bibechana-74254	235	3	antigens	antigen	NOUN
bibechana-74254	235	4	,	,	PUNCT
bibechana-74254	235	5	an	an	DET
bibechana-74254	235	6	emerging	emerge	VERB
bibechana-74254	235	7	family	family	NOUN
bibechana-74254	235	8	of	of	ADP
bibechana-74254	235	9	multifaceted	multifaceted	ADJ
bibechana-74254	235	10	master	master	NOUN
bibechana-74254	235	11	coregulators	coregulator	NOUN
bibechana-74254	235	12	.	.	PUNCT
bibechana-74254	236	1	282(3):1529–1533	282(3):1529–1533	NUM
bibechana-74254	236	2	,	,	PUNCT
bibechana-74254	236	3	2007	2007	NUM
bibechana-74254	236	4	.	.	PUNCT
bibechana-74254	237	1	[	[	X
bibechana-74254	237	2	19	19	NUM
bibechana-74254	237	3	]	]	PUNCT
bibechana-74254	237	4	a.	a.	NOUN
bibechana-74254	237	5	simpson	simpson	PROPN
bibechana-74254	237	6	et	et	PROPN
bibechana-74254	237	7	al	al	PROPN
bibechana-74254	237	8	.	.	PROPN
bibechana-74254	237	9	differential	differential	ADJ
bibechana-74254	237	10	expression	expression	NOUN
bibechana-74254	237	11	and	and	CCONJ
bibechana-74254	237	12	subcellular	subcellular	ADJ
bibechana-74254	237	13	distribution	distribution	NOUN
bibechana-74254	237	14	of	of	ADP
bibechana-74254	237	15	the	the	DET
bibechana-74254	237	16	mouse	mouse	NOUN
bibechana-74254	237	17	metastasis	metastasis	NOUN
bibechana-74254	237	18	-	-	PUNCT
bibechana-74254	237	19	associated	associate	VERB
bibechana-74254	237	20	proteins	protein	NOUN
bibechana-74254	237	21	mta1	mta1	NOUN
bibechana-74254	237	22	and	and	CCONJ
bibechana-74254	237	23	mta3	mta3	NOUN
bibechana-74254	237	24	.	.	PUNCT
bibechana-74254	238	1	273(1):29–39	273(1):29–39	NUM
bibechana-74254	238	2	,	,	PUNCT
bibechana-74254	238	3	2001	2001	NUM
bibechana-74254	238	4	.	.	PUNCT
bibechana-74254	239	1	[	[	X
bibechana-74254	239	2	20	20	NUM
bibechana-74254	239	3	]	]	X
bibechana-74254	239	4	y.	y.	PROPN
bibechana-74254	239	5	toh	toh	PROPN
bibechana-74254	239	6	,	,	PUNCT
bibechana-74254	239	7	s.d	s.d	PROPN
bibechana-74254	239	8	.	.	PROPN
bibechana-74254	239	9	pencil	pencil	PROPN
bibechana-74254	239	10	,	,	PUNCT
bibechana-74254	239	11	and	and	CCONJ
bibechana-74254	240	1	g.l	g.l	PROPN
bibechana-74254	240	2	.	.	PROPN
bibechana-74254	240	3	nicolson	nicolson	PROPN
bibechana-74254	240	4	.	.	PUNCT
bibechana-74254	241	1	a	a	DET
bibechana-74254	241	2	novel	novel	ADJ
bibechana-74254	241	3	candidate	candidate	NOUN
bibechana-74254	241	4	metastasis	metastasis	NOUN
bibechana-74254	241	5	-	-	PUNCT
bibechana-74254	241	6	associated	associated	ADJ
bibechana-74254	241	7	gene	gene	NOUN
bibechana-74254	241	8	,	,	PUNCT
bibechana-74254	241	9	mta1	mta1	PROPN
bibechana-74254	241	10	,	,	PUNCT
bibechana-74254	241	11	differentially	differentially	ADV
bibechana-74254	241	12	expressed	express	VERB
bibechana-74254	241	13	in	in	ADP
bibechana-74254	241	14	highly	highly	ADV
bibechana-74254	241	15	metastatic	metastatic	ADJ
bibechana-74254	241	16	mammary	mammary	ADJ
bibechana-74254	241	17	adenocarcinoma	adenocarcinoma	NOUN
bibechana-74254	241	18	cell	cell	NOUN
bibechana-74254	241	19	lines	line	NOUN
bibechana-74254	241	20	.	.	PUNCT
bibechana-74254	242	1	cdna	cdna	PROPN
bibechana-74254	242	2	cloning	cloning	NOUN
bibechana-74254	242	3	,	,	PUNCT
bibechana-74254	242	4	expression	expression	NOUN
bibechana-74254	242	5	,	,	PUNCT
bibechana-74254	242	6	and	and	CCONJ
bibechana-74254	242	7	protein	protein	NOUN
bibechana-74254	242	8	analyses	analysis	NOUN
bibechana-74254	242	9	.	.	PUNCT
bibechana-74254	243	1	269(37):22958–22963	269(37):22958–22963	NUM
bibechana-74254	243	2	,	,	PUNCT
bibechana-74254	243	3	1994	1994	NUM
bibechana-74254	243	4	.	.	PUNCT
bibechana-74254	244	1	narayan	narayan	PROPN
bibechana-74254	244	2	gautam	gautam	PROPN
bibechana-74254	244	3	and	and	CCONJ
bibechana-74254	244	4	narayan	narayan	PROPN
bibechana-74254	244	5	p.	p.	NOUN
bibechana-74254	244	6	adhikari/	adhikari/	NUM
bibechana-74254	244	7	bibechana	bibechana	NOUN
bibechana-74254	244	8	22	22	NUM
bibechana-74254	244	9	(	(	PUNCT
bibechana-74254	244	10	2025	2025	NUM
bibechana-74254	244	11	)	)	PUNCT
bibechana-74254	244	12	108	108	NUM
bibechana-74254	244	13	-	-	SYM
bibechana-74254	244	14	115	115	NUM
bibechana-74254	244	15	115	115	NUM
bibechana-74254	245	1	[	[	X
bibechana-74254	245	2	21	21	NUM
bibechana-74254	245	3	]	]	PUNCT
bibechana-74254	245	4	m.	m.	NOUN
bibechana-74254	245	5	esteller	esteller	NOUN
bibechana-74254	245	6	.	.	PUNCT
bibechana-74254	246	1	dna	dna	PROPN
bibechana-74254	246	2	methylation	methylation	NOUN
bibechana-74254	246	3	,	,	PUNCT
bibechana-74254	246	4	epigenetics	epigenetic	NOUN
bibechana-74254	246	5	and	and	CCONJ
bibechana-74254	246	6	metastasis	metastasis	NOUN
bibechana-74254	246	7	,	,	PUNCT
bibechana-74254	246	8	volume	volume	NOUN
bibechana-74254	246	9	7	7	NUM
bibechana-74254	246	10	.	.	PUNCT
bibechana-74254	246	11	springer	springer	NOUN
bibechana-74254	246	12	science	science	PROPN
bibechana-74254	246	13	&	&	CCONJ
bibechana-74254	246	14	business	business	NOUN
bibechana-74254	246	15	media	medium	NOUN
bibechana-74254	246	16	,	,	PUNCT
bibechana-74254	246	17	2005	2005	NUM
bibechana-74254	246	18	.	.	PUNCT
bibechana-74254	247	1	[	[	X
bibechana-74254	247	2	22	22	NUM
bibechana-74254	247	3	]	]	X
bibechana-74254	247	4	y.	y.	PROPN
bibechana-74254	247	5	xue	xue	PROPN
bibechana-74254	247	6	et	et	PROPN
bibechana-74254	247	7	al	al	PROPN
bibechana-74254	247	8	.	.	PROPN
bibechana-74254	247	9	nurd	nurd	PROPN
bibechana-74254	247	10	,	,	PUNCT
bibechana-74254	247	11	a	a	DET
bibechana-74254	247	12	novel	novel	ADJ
bibechana-74254	247	13	complex	complex	NOUN
bibechana-74254	247	14	with	with	ADP
bibechana-74254	247	15	both	both	DET
bibechana-74254	247	16	atp	atp	NOUN
bibechana-74254	247	17	-	-	PUNCT
bibechana-74254	247	18	dependent	dependent	ADJ
bibechana-74254	247	19	chromatin	chromatin	NOUN
bibechana-74254	247	20	-	-	PUNCT
bibechana-74254	247	21	remodeling	remodeling	NOUN
bibechana-74254	247	22	and	and	CCONJ
bibechana-74254	247	23	histone	histone	NOUN
bibechana-74254	247	24	deacetylase	deacetylase	NOUN
bibechana-74254	247	25	activities	activity	NOUN
bibechana-74254	247	26	.	.	PUNCT
bibechana-74254	248	1	2(6):851–861	2(6):851–861	NUM
bibechana-74254	248	2	,	,	PUNCT
bibechana-74254	248	3	1998	1998	NUM
bibechana-74254	248	4	.	.	PUNCT
bibechana-74254	249	1	[	[	X
bibechana-74254	249	2	23	23	NUM
bibechana-74254	249	3	]	]	X
bibechana-74254	249	4	y.	y.	PROPN
bibechana-74254	249	5	zhang	zhang	PROPN
bibechana-74254	249	6	et	et	PROPN
bibechana-74254	249	7	al	al	PROPN
bibechana-74254	249	8	.	.	PUNCT
bibechana-74254	250	1	analysis	analysis	NOUN
bibechana-74254	250	2	of	of	ADP
bibechana-74254	250	3	the	the	DET
bibechana-74254	250	4	nurd	nurd	PROPN
bibechana-74254	250	5	subunits	subunit	NOUN
bibechana-74254	250	6	reveals	reveal	VERB
bibechana-74254	250	7	a	a	DET
bibechana-74254	250	8	histone	histone	NOUN
bibechana-74254	250	9	deacetylase	deacetylase	NOUN
bibechana-74254	250	10	core	core	NOUN
bibechana-74254	250	11	complex	complex	NOUN
bibechana-74254	250	12	and	and	CCONJ
bibechana-74254	250	13	a	a	DET
bibechana-74254	250	14	connection	connection	NOUN
bibechana-74254	250	15	with	with	ADP
bibechana-74254	250	16	dna	dna	PROPN
bibechana-74254	250	17	methylation	methylation	NOUN
bibechana-74254	250	18	.	.	PUNCT
bibechana-74254	251	1	13(15):1924–1935	13(15):1924–1935	NUM
bibechana-74254	251	2	,	,	PUNCT
bibechana-74254	251	3	1999	1999	NUM
bibechana-74254	251	4	.	.	PUNCT
bibechana-74254	252	1	[	[	X
bibechana-74254	252	2	24	24	NUM
bibechana-74254	252	3	]	]	PUNCT
bibechana-74254	252	4	l.	l.	PROPN
bibechana-74254	252	5	wang	wang	PROPN
bibechana-74254	252	6	et	et	PROPN
bibechana-74254	252	7	al	al	PROPN
bibechana-74254	252	8	.	.	PROPN
bibechana-74254	252	9	atrophin	atrophin	PROPN
bibechana-74254	252	10	recruits	recruit	VERB
bibechana-74254	252	11	hdac1/2	hdac1/2	PROPN
bibechana-74254	252	12	and	and	CCONJ
bibechana-74254	252	13	g9a	g9a	PROPN
bibechana-74254	252	14	to	to	PART
bibechana-74254	252	15	modify	modify	VERB
bibechana-74254	252	16	histone	histone	PROPN
bibechana-74254	252	17	h3k9	h3k9	PROPN
bibechana-74254	252	18	and	and	CCONJ
bibechana-74254	252	19	to	to	PART
bibechana-74254	252	20	determine	determine	VERB
bibechana-74254	252	21	cell	cell	NOUN
bibechana-74254	252	22	fates	fate	NOUN
bibechana-74254	252	23	.	.	PUNCT
bibechana-74254	253	1	9(6):555–562	9(6):555–562	NUM
bibechana-74254	253	2	,	,	PUNCT
bibechana-74254	253	3	2008	2008	NUM
bibechana-74254	253	4	.	.	PUNCT
bibechana-74254	254	1	[	[	X
bibechana-74254	254	2	25	25	NUM
bibechana-74254	254	3	]	]	X
bibechana-74254	254	4	c.j	c.j	PROPN
bibechana-74254	254	5	.	.	PROPN
bibechana-74254	254	6	millard	millard	PROPN
bibechana-74254	254	7	et	et	PROPN
bibechana-74254	254	8	al	al	PROPN
bibechana-74254	254	9	.	.	PUNCT
bibechana-74254	254	10	class	class	NOUN
bibechana-74254	254	11	i	i	PRON
bibechana-74254	254	12	hdacs	hdac	VERB
bibechana-74254	254	13	share	share	VERB
bibechana-74254	254	14	a	a	DET
bibechana-74254	254	15	common	common	ADJ
bibechana-74254	254	16	mechanism	mechanism	NOUN
bibechana-74254	254	17	of	of	ADP
bibechana-74254	254	18	regulation	regulation	NOUN
bibechana-74254	254	19	by	by	ADP
bibechana-74254	254	20	inositol	inositol	NOUN
bibechana-74254	254	21	phosphates	phosphate	NOUN
bibechana-74254	254	22	.	.	PUNCT
bibechana-74254	255	1	51(1):57–67	51(1):57–67	NUM
bibechana-74254	255	2	,	,	PUNCT
bibechana-74254	255	3	2013	2013	NUM
bibechana-74254	255	4	.	.	PUNCT
bibechana-74254	256	1	[	[	X
bibechana-74254	256	2	26	26	NUM
bibechana-74254	256	3	]	]	X
bibechana-74254	256	4	a.j	a.j	PROPN
bibechana-74254	256	5	.	.	PROPN
bibechana-74254	256	6	ruijter	ruijter	PROPN
bibechana-74254	256	7	et	et	PROPN
bibechana-74254	256	8	al	al	PROPN
bibechana-74254	256	9	.	.	PUNCT
bibechana-74254	257	1	histone	histone	NOUN
bibechana-74254	257	2	deacetylases	deacetylase	NOUN
bibechana-74254	257	3	(	(	PUNCT
bibechana-74254	257	4	hdacs	hdac	NOUN
bibechana-74254	257	5	):	):	PUNCT
bibechana-74254	257	6	characterization	characterization	NOUN
bibechana-74254	257	7	of	of	ADP
bibechana-74254	257	8	the	the	DET
bibechana-74254	257	9	classical	classical	ADJ
bibechana-74254	257	10	hdac	hdac	NOUN
bibechana-74254	257	11	family	family	NOUN
bibechana-74254	257	12	.	.	PUNCT
bibechana-74254	258	1	370(3):737–749	370(3):737–749	ADP
bibechana-74254	258	2	,	,	PUNCT
bibechana-74254	258	3	2003	2003	NUM
bibechana-74254	258	4	.	.	PUNCT
bibechana-74254	259	1	[	[	X
bibechana-74254	259	2	27	27	NUM
bibechana-74254	259	3	]	]	X
bibechana-74254	259	4	j.	j.	PROPN
bibechana-74254	259	5	taplick	taplick	PROPN
bibechana-74254	259	6	et	et	PROPN
bibechana-74254	259	7	al	al	PROPN
bibechana-74254	259	8	.	.	PUNCT
bibechana-74254	259	9	homo	homo	NOUN
bibechana-74254	259	10	-	-	PUNCT
bibechana-74254	259	11	oligomerisation	oligomerisation	NOUN
bibechana-74254	259	12	and	and	CCONJ
bibechana-74254	259	13	nuclear	nuclear	ADJ
bibechana-74254	259	14	localisation	localisation	NOUN
bibechana-74254	259	15	of	of	ADP
bibechana-74254	259	16	mouse	mouse	PROPN
bibechana-74254	259	17	histone	histone	PROPN
bibechana-74254	259	18	deacetylase	deacetylase	PROPN
bibechana-74254	259	19	1	1	NUM
bibechana-74254	259	20	.	.	PUNCT
bibechana-74254	259	21	308(1):27–38	308(1):27–38	NUM
bibechana-74254	259	22	,	,	PUNCT
bibechana-74254	259	23	2001	2001	NUM
bibechana-74254	259	24	.	.	PUNCT
bibechana-74254	260	1	[	[	X
bibechana-74254	260	2	28	28	NUM
bibechana-74254	260	3	]	]	X
bibechana-74254	260	4	n.	n.	PROPN
bibechana-74254	260	5	gautam	gautam	PROPN
bibechana-74254	260	6	et	et	PROPN
bibechana-74254	260	7	al	al	PROPN
bibechana-74254	260	8	.	.	PUNCT
bibechana-74254	260	9	characterization	characterization	NOUN
bibechana-74254	260	10	of	of	ADP
bibechana-74254	260	11	molecular	molecular	ADJ
bibechana-74254	260	12	interactions	interaction	NOUN
bibechana-74254	260	13	between	between	ADP
bibechana-74254	260	14	hdac7	hdac7	PROPN
bibechana-74254	260	15	and	and	CCONJ
bibechana-74254	260	16	mef2a	mef2a	PROPN
bibechana-74254	260	17	.	.	PROPN
bibechana-74254	260	18	journal	journal	PROPN
bibechana-74254	260	19	of	of	ADP
bibechana-74254	260	20	biomolecular	biomolecular	ADJ
bibechana-74254	260	21	structure	structure	NOUN
bibechana-74254	260	22	and	and	CCONJ
bibechana-74254	260	23	dynamics	dynamic	NOUN
bibechana-74254	260	24	,	,	PUNCT
bibechana-74254	260	25	pages	page	NOUN
bibechana-74254	260	26	1–10	1–10	NOUN
bibechana-74254	260	27	,	,	PUNCT
bibechana-74254	260	28	2024	2024	NUM
bibechana-74254	260	29	.	.	PUNCT
bibechana-74254	261	1	[	[	X
bibechana-74254	261	2	29	29	NUM
bibechana-74254	261	3	]	]	X
bibechana-74254	261	4	l.s	l.s	NOUN
bibechana-74254	261	5	.	.	PROPN
bibechana-74254	261	6	dhami	dhami	PROPN
bibechana-74254	261	7	et	et	PROPN
bibechana-74254	261	8	al	al	PROPN
bibechana-74254	261	9	.	.	PUNCT
bibechana-74254	262	1	insights	insight	NOUN
bibechana-74254	262	2	from	from	ADP
bibechana-74254	262	3	in	in	ADP
bibechana-74254	262	4	silico	silico	NOUN
bibechana-74254	262	5	study	study	NOUN
bibechana-74254	262	6	of	of	ADP
bibechana-74254	262	7	receptor	receptor	NOUN
bibechana-74254	262	8	energetics	energetic	NOUN
bibechana-74254	262	9	of	of	ADP
bibechana-74254	262	10	sars	sar	NOUN
bibechana-74254	262	11	-	-	PUNCT
bibechana-74254	262	12	cov-2	cov-2	NOUN
bibechana-74254	262	13	variants	variant	NOUN
bibechana-74254	262	14	.	.	PUNCT
bibechana-74254	263	1	26(11):8794–8806	26(11):8794–8806	NUM
bibechana-74254	263	2	,	,	PUNCT
bibechana-74254	263	3	2024	2024	NUM
bibechana-74254	263	4	.	.	PUNCT
bibechana-74254	264	1	[	[	X
bibechana-74254	264	2	30	30	NUM
bibechana-74254	264	3	]	]	X
bibechana-74254	264	4	j.	j.	PROPN
bibechana-74254	264	5	jumper	jumper	PROPN
bibechana-74254	264	6	et	et	PROPN
bibechana-74254	264	7	al	al	PROPN
bibechana-74254	264	8	.	.	PUNCT
bibechana-74254	264	9	highly	highly	ADV
bibechana-74254	264	10	accurate	accurate	ADJ
bibechana-74254	264	11	protein	protein	NOUN
bibechana-74254	264	12	structure	structure	NOUN
bibechana-74254	264	13	prediction	prediction	NOUN
bibechana-74254	264	14	with	with	ADP
bibechana-74254	264	15	alphafold	alphafold	ADJ
bibechana-74254	264	16	.	.	PUNCT
bibechana-74254	265	1	596(7873):583	596(7873):583	NUM
bibechana-74254	265	2	–	–	PUNCT
bibechana-74254	265	3	589	589	NUM
bibechana-74254	265	4	,	,	PUNCT
bibechana-74254	265	5	2021	2021	NUM
bibechana-74254	265	6	.	.	PUNCT
bibechana-74254	266	1	[	[	X
bibechana-74254	266	2	31	31	NUM
bibechana-74254	266	3	]	]	PUNCT
bibechana-74254	266	4	uniprot	uniprot	ADJ
bibechana-74254	266	5	consortium	consortium	NOUN
bibechana-74254	266	6	.	.	PUNCT
bibechana-74254	267	1	uniprot	uniprot	ADJ
bibechana-74254	267	2	:	:	PUNCT
bibechana-74254	267	3	the	the	DET
bibechana-74254	267	4	universal	universal	ADJ
bibechana-74254	267	5	protein	protein	NOUN
bibechana-74254	267	6	knowledgebase	knowledgebase	NOUN
bibechana-74254	267	7	in	in	ADP
bibechana-74254	267	8	2023	2023	NUM
bibechana-74254	267	9	.	.	PUNCT
bibechana-74254	268	1	nucleic	nucleic	ADJ
bibechana-74254	268	2	acids	acid	NOUN
bibechana-74254	268	3	research	research	NOUN
bibechana-74254	268	4	,	,	PUNCT
bibechana-74254	268	5	51(d1):d523	51(d1):d523	NUM
bibechana-74254	268	6	–	–	PUNCT
bibechana-74254	268	7	d531	d531	PROPN
bibechana-74254	268	8	,	,	PUNCT
bibechana-74254	268	9	2022	2022	NUM
bibechana-74254	268	10	.	.	PUNCT
bibechana-74254	269	1	[	[	X
bibechana-74254	269	2	32	32	NUM
bibechana-74254	269	3	]	]	X
bibechana-74254	269	4	j.c	j.c	PROPN
bibechana-74254	269	5	.	.	PROPN
bibechana-74254	269	6	phillips	phillips	PROPN
bibechana-74254	269	7	et	et	PROPN
bibechana-74254	269	8	al	al	PROPN
bibechana-74254	269	9	.	.	PROPN
bibechana-74254	269	10	scalable	scalable	ADJ
bibechana-74254	269	11	molecular	molecular	ADJ
bibechana-74254	269	12	dynamics	dynamic	NOUN
bibechana-74254	269	13	with	with	ADP
bibechana-74254	269	14	namd	namd	NOUN
bibechana-74254	269	15	.	.	PUNCT
bibechana-74254	270	1	26(16):1781–1802	26(16):1781–1802	NUM
bibechana-74254	270	2	,	,	PUNCT
bibechana-74254	270	3	2005	2005	NUM
bibechana-74254	270	4	.	.	PUNCT
bibechana-74254	271	1	[	[	X
bibechana-74254	271	2	33	33	NUM
bibechana-74254	271	3	]	]	PUNCT
bibechana-74254	271	4	j.	j.	PROPN
bibechana-74254	271	5	huang	huang	PROPN
bibechana-74254	271	6	et	et	PROPN
bibechana-74254	271	7	al	al	PROPN
bibechana-74254	271	8	.	.	PROPN
bibechana-74254	271	9	charmm36	charmm36	PROPN
bibechana-74254	271	10	m	m	PROPN
bibechana-74254	271	11	:	:	PUNCT
bibechana-74254	271	12	an	an	DET
bibechana-74254	271	13	improved	improved	ADJ
bibechana-74254	271	14	force	force	NOUN
bibechana-74254	271	15	field	field	NOUN
bibechana-74254	271	16	for	for	ADP
bibechana-74254	271	17	folded	folded	ADJ
bibechana-74254	271	18	and	and	CCONJ
bibechana-74254	271	19	intrinsically	intrinsically	ADV
bibechana-74254	271	20	disordered	disordered	ADJ
bibechana-74254	271	21	proteins	protein	NOUN
bibechana-74254	271	22	.	.	PUNCT
bibechana-74254	272	1	14(1):71–73	14(1):71–73	NUM
bibechana-74254	272	2	,	,	PUNCT
bibechana-74254	272	3	2017	2017	NUM
bibechana-74254	272	4	.	.	PUNCT
bibechana-74254	273	1	[	[	X
bibechana-74254	273	2	34	34	NUM
bibechana-74254	273	3	]	]	X
bibechana-74254	273	4	p.b	p.b	PROPN
bibechana-74254	273	5	.	.	PROPN
bibechana-74254	273	6	tiwari	tiwari	PROPN
bibechana-74254	273	7	et	et	PROPN
bibechana-74254	273	8	al	al	PROPN
bibechana-74254	273	9	.	.	PROPN
bibechana-74254	273	10	covalent	covalent	PROPN
bibechana-74254	273	11	complex	complex	NOUN
bibechana-74254	273	12	of	of	ADP
bibechana-74254	273	13	dna	dna	PROPN
bibechana-74254	273	14	and	and	CCONJ
bibechana-74254	273	15	bacterial	bacterial	ADJ
bibechana-74254	273	16	topoisomerase	topoisomerase	NOUN
bibechana-74254	273	17	:	:	PUNCT
bibechana-74254	273	18	implications	implication	NOUN
bibechana-74254	273	19	in	in	ADP
bibechana-74254	273	20	antibacterial	antibacterial	ADJ
bibechana-74254	273	21	drug	drug	NOUN
bibechana-74254	273	22	development	development	NOUN
bibechana-74254	273	23	.	.	PUNCT
bibechana-74254	274	1	15(7):623–631	15(7):623–631	NUM
bibechana-74254	274	2	,	,	PUNCT
bibechana-74254	274	3	2020	2020	NUM
bibechana-74254	274	4	.	.	PUNCT
bibechana-74254	275	1	[	[	X
bibechana-74254	275	2	35	35	NUM
bibechana-74254	275	3	]	]	X
bibechana-74254	275	4	j.	j.	PROPN
bibechana-74254	275	5	lee	lee	PROPN
bibechana-74254	275	6	et	et	PROPN
bibechana-74254	275	7	al	al	PROPN
bibechana-74254	275	8	.	.	PROPN
bibechana-74254	275	9	charmm	charmm	PROPN
bibechana-74254	275	10	-	-	PUNCT
bibechana-74254	275	11	gui	gui	NOUN
bibechana-74254	275	12	input	input	NOUN
bibechana-74254	275	13	generator	generator	NOUN
bibechana-74254	275	14	for	for	ADP
bibechana-74254	275	15	namd	namd	NOUN
bibechana-74254	275	16	,	,	PUNCT
bibechana-74254	275	17	gromacs	gromacs	PROPN
bibechana-74254	275	18	,	,	PUNCT
bibechana-74254	275	19	amber	amber	PROPN
bibechana-74254	275	20	,	,	PUNCT
bibechana-74254	275	21	openmm	openmm	PROPN
bibechana-74254	275	22	,	,	PUNCT
bibechana-74254	275	23	and	and	CCONJ
bibechana-74254	275	24	charmm	charmm	NOUN
bibechana-74254	275	25	/	/	SYM
bibechana-74254	275	26	openmm	openmm	NOUN
bibechana-74254	275	27	simulations	simulation	NOUN
bibechana-74254	275	28	using	use	VERB
bibechana-74254	275	29	the	the	DET
bibechana-74254	275	30	charmm36	charmm36	NOUN
bibechana-74254	275	31	additive	additive	ADJ
bibechana-74254	275	32	force	force	NOUN
bibechana-74254	275	33	field	field	NOUN
bibechana-74254	275	34	.	.	PUNCT
bibechana-74254	276	1	110(3):641a	110(3):641a	NUM
bibechana-74254	276	2	,	,	PUNCT
bibechana-74254	276	3	2016	2016	NUM
bibechana-74254	276	4	.	.	PUNCT
bibechana-74254	277	1	[	[	X
bibechana-74254	277	2	36	36	NUM
bibechana-74254	277	3	]	]	X
bibechana-74254	277	4	w.	w.	PROPN
bibechana-74254	277	5	humphrey	humphrey	PROPN
bibechana-74254	277	6	,	,	PUNCT
bibechana-74254	277	7	a.	a.	PROPN
bibechana-74254	277	8	dalke	dalke	PROPN
bibechana-74254	277	9	,	,	PUNCT
bibechana-74254	277	10	and	and	CCONJ
bibechana-74254	277	11	k.	k.	PROPN
bibechana-74254	277	12	schulten	schulten	PROPN
bibechana-74254	277	13	.	.	PUNCT
bibechana-74254	278	1	vmd	vmd	PROPN
bibechana-74254	278	2	:	:	PUNCT
bibechana-74254	278	3	visual	visual	ADJ
bibechana-74254	278	4	molecular	molecular	ADJ
bibechana-74254	278	5	dynamics	dynamic	NOUN
bibechana-74254	278	6	.	.	PUNCT
bibechana-74254	279	1	journal	journal	NOUN
bibechana-74254	279	2	of	of	ADP
bibechana-74254	279	3	molecular	molecular	ADJ
bibechana-74254	279	4	graphics	graphic	NOUN
bibechana-74254	279	5	,	,	PUNCT
bibechana-74254	279	6	14(1):33–38	14(1):33–38	NUM
bibechana-74254	279	7	,	,	PUNCT
bibechana-74254	279	8	1996	1996	NUM
bibechana-74254	279	9	.	.	PUNCT
bibechana-74254	280	1	[	[	X
bibechana-74254	280	2	37	37	NUM
bibechana-74254	280	3	]	]	X
bibechana-74254	280	4	e.f	e.f	PROPN
bibechana-74254	280	5	.	.	PROPN
bibechana-74254	280	6	pettersen	pettersen	PROPN
bibechana-74254	280	7	et	et	PROPN
bibechana-74254	280	8	al	al	PROPN
bibechana-74254	280	9	.	.	PROPN
bibechana-74254	281	1	ucsf	ucsf	PROPN
bibechana-74254	281	2	chimerax	chimerax	PROPN
bibechana-74254	281	3	:	:	PUNCT
bibechana-74254	281	4	structure	structure	NOUN
bibechana-74254	281	5	visualization	visualization	NOUN
bibechana-74254	281	6	for	for	ADP
bibechana-74254	281	7	researchers	researcher	NOUN
bibechana-74254	281	8	,	,	PUNCT
bibechana-74254	281	9	educators	educator	NOUN
bibechana-74254	281	10	,	,	PUNCT
bibechana-74254	281	11	and	and	CCONJ
bibechana-74254	281	12	developers	developer	NOUN
bibechana-74254	281	13	.	.	PUNCT
bibechana-74254	282	1	30(1):70–82	30(1):70–82	NUM
bibechana-74254	282	2	,	,	PUNCT
bibechana-74254	282	3	2021	2021	NUM
bibechana-74254	282	4	.	.	PUNCT
bibechana-74254	283	1	[	[	X
bibechana-74254	283	2	38	38	NUM
bibechana-74254	283	3	]	]	PUNCT
bibechana-74254	283	4	x.	x.	PROPN
bibechana-74254	283	5	zhang	zhang	PROPN
bibechana-74254	283	6	,	,	PUNCT
bibechana-74254	283	7	h.	h.	PROPN
bibechana-74254	283	8	perez	perez	PROPN
bibechana-74254	283	9	-	-	PUNCT
bibechana-74254	283	10	sanchez	sanchez	PROPN
bibechana-74254	283	11	,	,	PUNCT
bibechana-74254	283	12	and	and	CCONJ
bibechana-74254	283	13	f.c	f.c	PROPN
bibechana-74254	283	14	.	.	PROPN
bibechana-74254	283	15	lightstone	lightstone	PROPN
bibechana-74254	283	16	.	.	PUNCT
bibechana-74254	284	1	a	a	DET
bibechana-74254	284	2	comprehensive	comprehensive	ADJ
bibechana-74254	284	3	docking	docking	NOUN
bibechana-74254	284	4	and	and	CCONJ
bibechana-74254	284	5	mm	mm	PROPN
bibechana-74254	284	6	/	/	SYM
bibechana-74254	284	7	gbsa	gbsa	ADJ
bibechana-74254	284	8	rescoring	rescoring	NOUN
bibechana-74254	284	9	study	study	NOUN
bibechana-74254	284	10	of	of	ADP
bibechana-74254	284	11	ligand	ligand	ADJ
bibechana-74254	284	12	recognition	recognition	NOUN
bibechana-74254	284	13	upon	upon	SCONJ
bibechana-74254	284	14	binding	bind	VERB
bibechana-74254	284	15	antithrombin	antithrombin	NOUN
bibechana-74254	284	16	.	.	PUNCT
bibechana-74254	285	1	17(14):1631–1639	17(14):1631–1639	NUM
bibechana-74254	285	2	,	,	PUNCT
bibechana-74254	285	3	2017	2017	NUM
bibechana-74254	285	4	.	.	PUNCT
bibechana-74254	286	1	[	[	X
bibechana-74254	286	2	39	39	NUM
bibechana-74254	286	3	]	]	PUNCT
bibechana-74254	286	4	x.	x.	NOUN
bibechana-74254	286	5	zou	zou	PROPN
bibechana-74254	286	6	et	et	PROPN
bibechana-74254	286	7	al	al	PROPN
bibechana-74254	286	8	.	.	PUNCT
bibechana-74254	286	9	recognition	recognition	NOUN
bibechana-74254	286	10	of	of	ADP
bibechana-74254	286	11	methylated	methylate	VERB
bibechana-74254	286	12	dna	dna	NOUN
bibechana-74254	286	13	through	through	ADP
bibechana-74254	286	14	methyl	methyl	NOUN
bibechana-74254	286	15	-	-	PUNCT
bibechana-74254	286	16	cpg	cpg	NOUN
bibechana-74254	286	17	binding	bind	VERB
bibechana-74254	286	18	domain	domain	NOUN
bibechana-74254	286	19	proteins	protein	NOUN
bibechana-74254	286	20	.	.	PUNCT
bibechana-74254	287	1	40(6):2747–2758	40(6):2747–2758	NUM
bibechana-74254	287	2	,	,	PUNCT
bibechana-74254	287	3	2012	2012	NUM
bibechana-74254	287	4	.	.	PUNCT
bibechana-74254	288	1	[	[	X
bibechana-74254	288	2	40	40	NUM
bibechana-74254	288	3	]	]	PUNCT
bibechana-74254	288	4	r.	r.	PROPN
bibechana-74254	288	5	yin	yin	PROPN
bibechana-74254	288	6	et	et	PROPN
bibechana-74254	288	7	al	al	PROPN
bibechana-74254	288	8	.	.	PUNCT
bibechana-74254	289	1	benchmarking	benchmarke	VERB
bibechana-74254	289	2	alphafold	alphafold	ADJ
bibechana-74254	289	3	for	for	ADP
bibechana-74254	289	4	protein	protein	NOUN
bibechana-74254	289	5	complex	complex	ADJ
bibechana-74254	289	6	modeling	modeling	NOUN
bibechana-74254	289	7	reveals	reveal	VERB
bibechana-74254	289	8	accuracy	accuracy	NOUN
bibechana-74254	289	9	determinants	determinant	NOUN
bibechana-74254	289	10	.	.	PUNCT
bibechana-74254	290	1	31(8):e4379	31(8):e4379	ADP
bibechana-74254	290	2	,	,	PUNCT
bibechana-74254	290	3	2022	2022	NUM
bibechana-74254	290	4	.	.	PUNCT
bibechana-74254	291	1	[	[	X
bibechana-74254	291	2	41	41	NUM
bibechana-74254	291	3	]	]	PUNCT
bibechana-74254	291	4	j.	j.	PROPN
bibechana-74254	291	5	salamanca	salamanca	PROPN
bibechana-74254	291	6	viloria	viloria	PROPN
bibechana-74254	291	7	et	et	PROPN
bibechana-74254	291	8	al	al	PROPN
bibechana-74254	291	9	.	.	PUNCT
bibechana-74254	292	1	an	an	DET
bibechana-74254	292	2	optimal	optimal	ADJ
bibechana-74254	292	3	distance	distance	NOUN
bibechana-74254	292	4	cutoff	cutoff	NOUN
bibechana-74254	292	5	for	for	ADP
bibechana-74254	292	6	contact	contact	NOUN
bibechana-74254	292	7	-	-	PUNCT
bibechana-74254	292	8	based	base	VERB
bibechana-74254	292	9	protein	protein	NOUN
bibechana-74254	292	10	structure	structure	NOUN
bibechana-74254	292	11	networks	network	NOUN
bibechana-74254	292	12	using	use	VERB
bibechana-74254	292	13	side	side	NOUN
bibechana-74254	292	14	-	-	PUNCT
bibechana-74254	292	15	chain	chain	NOUN
bibechana-74254	292	16	centers	center	NOUN
bibechana-74254	292	17	of	of	ADP
bibechana-74254	292	18	mass	mass	PROPN
bibechana-74254	292	19	.	.	PUNCT
bibechana-74254	293	1	7(1):2838	7(1):2838	NUM
bibechana-74254	293	2	,	,	PUNCT
bibechana-74254	293	3	2017	2017	NUM
bibechana-74254	293	4	.	.	PUNCT
bibechana-74254	294	1	introduction	introduction	NOUN
bibechana-74254	294	2	methods	method	NOUN
bibechana-74254	294	3	system	system	NOUN
bibechana-74254	294	4	preparation	preparation	NOUN
bibechana-74254	294	5	md	md	PROPN
bibechana-74254	294	6	simulations	simulation	VERB
bibechana-74254	294	7	data	datum	NOUN
bibechana-74254	294	8	analysis	analysis	NOUN
bibechana-74254	294	9	results	result	NOUN
bibechana-74254	294	10	and	and	CCONJ
bibechana-74254	294	11	discussion	discussion	NOUN
bibechana-74254	294	12	prediction	prediction	NOUN
bibechana-74254	294	13	of	of	ADP
bibechana-74254	294	14	the	the	DET
bibechana-74254	294	15	hdac2	hdac2	NOUN
bibechana-74254	294	16	-	-	PUNCT
bibechana-74254	294	17	mta1	mta1	PROPN
bibechana-74254	294	18	complex	complex	ADJ
bibechana-74254	294	19	structural	structural	ADJ
bibechana-74254	294	20	stability	stability	NOUN
bibechana-74254	294	21	of	of	ADP
bibechana-74254	294	22	the	the	DET
bibechana-74254	294	23	hdac2	hdac2	NOUN
bibechana-74254	294	24	-	-	PUNCT
bibechana-74254	294	25	mta1	mta1	PROPN
bibechana-74254	294	26	complex	complex	ADJ
bibechana-74254	294	27	major	major	ADJ
bibechana-74254	294	28	interaction	interaction	NOUN
bibechana-74254	294	29	involved	involve	VERB
bibechana-74254	294	30	in	in	ADP
bibechana-74254	294	31	the	the	DET
bibechana-74254	294	32	complex	complex	ADJ
bibechana-74254	294	33	formation	formation	NOUN
bibechana-74254	294	34	and	and	CCONJ
bibechana-74254	294	35	stabilization	stabilization	NOUN
bibechana-74254	294	36	hydrogen	hydrogen	NOUN
bibechana-74254	294	37	bonding	bonding	NOUN
bibechana-74254	294	38	between	between	ADP
bibechana-74254	294	39	hdac2	hdac2	NOUN
bibechana-74254	294	40	and	and	CCONJ
bibechana-74254	294	41	mta1	mta1	NOUN
bibechana-74254	294	42	contribution	contribution	NOUN
bibechana-74254	294	43	of	of	ADP
bibechana-74254	294	44	a	a	DET
bibechana-74254	294	45	salt	salt	NOUN
bibechana-74254	294	46	bridge	bridge	NOUN
bibechana-74254	294	47	for	for	ADP
bibechana-74254	294	48	the	the	DET
bibechana-74254	294	49	formation	formation	NOUN
bibechana-74254	294	50	of	of	ADP
bibechana-74254	294	51	the	the	DET
bibechana-74254	294	52	hdac7	hdac7	PROPN
bibechana-74254	294	53	-	-	PUNCT
bibechana-74254	294	54	mef2a	mef2a	PROPN
bibechana-74254	294	55	complex	complex	ADJ
bibechana-74254	294	56	contribution	contribution	NOUN
bibechana-74254	294	57	due	due	ADP
bibechana-74254	294	58	to	to	ADP
bibechana-74254	294	59	hydrophobic	hydrophobic	NOUN
bibechana-74254	294	60	interactions	interaction	NOUN
bibechana-74254	294	61	binding	bind	VERB
bibechana-74254	294	62	free	free	ADJ
bibechana-74254	294	63	energy	energy	NOUN
bibechana-74254	294	64	of	of	ADP
bibechana-74254	294	65	the	the	DET
bibechana-74254	294	66	complex	complex	ADJ
bibechana-74254	294	67	conclusions	conclusion	NOUN