id	sid	tid	token	lemma	pos
bibechana-80853	1	1	bibechana	bibechana	PROPN
bibechana-80853	1	2	vol	vol	NOUN
bibechana-80853	1	3	.	.	PROPN
bibechana-80853	2	1	22	22	NUM
bibechana-80853	2	2	,	,	PUNCT
bibechana-80853	2	3	no	no	INTJ
bibechana-80853	2	4	.	.	NOUN
bibechana-80853	2	5	3	3	NUM
bibechana-80853	2	6	,	,	PUNCT
bibechana-80853	2	7	december	december	PROPN
bibechana-80853	2	8	2025	2025	NUM
bibechana-80853	2	9	,	,	PUNCT
bibechana-80853	2	10	291	291	NUM
bibechana-80853	2	11	-	-	SYM
bibechana-80853	2	12	298	298	NUM
bibechana-80853	2	13	issn	issn	PROPN
bibechana-80853	2	14	2091	2091	NUM
bibechana-80853	2	15	-	-	SYM
bibechana-80853	2	16	0762	0762	NUM
bibechana-80853	2	17	(	(	PUNCT
bibechana-80853	2	18	print	print	NOUN
bibechana-80853	2	19	)	)	PUNCT
bibechana-80853	2	20	,	,	PUNCT
bibechana-80853	2	21	2382	2382	NUM
bibechana-80853	2	22	-	-	SYM
bibechana-80853	2	23	5340	5340	NUM
bibechana-80853	2	24	(	(	PUNCT
bibechana-80853	2	25	online	online	ADJ
bibechana-80853	2	26	)	)	PUNCT
bibechana-80853	2	27	journal	journal	NOUN
bibechana-80853	2	28	homepage	homepage	NOUN
bibechana-80853	2	29	:	:	PUNCT
bibechana-80853	2	30	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-80853	2	31	publisher	publisher	NOUN
bibechana-80853	2	32	:	:	PUNCT
bibechana-80853	2	33	dept	dept	NOUN
bibechana-80853	2	34	.	.	PROPN
bibechana-80853	2	35	of	of	ADP
bibechana-80853	2	36	phys	phy	NOUN
bibechana-80853	2	37	.	.	PUNCT
bibechana-80853	2	38	,	,	PUNCT
bibechana-80853	3	1	mahendra	mahendra	PROPN
bibechana-80853	3	2	morang	morang	PROPN
bibechana-80853	3	3	a.	a.	PROPN
bibechana-80853	3	4	m.	m.	PROPN
bibechana-80853	3	5	campus	campus	PROPN
bibechana-80853	3	6	(	(	PUNCT
bibechana-80853	3	7	tribhuvan	tribhuvan	NOUN
bibechana-80853	3	8	university)biratnagar	university)biratnagar	PRON
bibechana-80853	3	9	in	in	ADP
bibechana-80853	3	10	silico	silico	NOUN
bibechana-80853	3	11	molecular	molecular	ADJ
bibechana-80853	3	12	docking	docking	NOUN
bibechana-80853	3	13	and	and	CCONJ
bibechana-80853	3	14	admet	admet	VERB
bibechana-80853	3	15	analysis	analysis	NOUN
bibechana-80853	3	16	of	of	ADP
bibechana-80853	3	17	the	the	DET
bibechana-80853	3	18	phytochemicals	phytochemical	NOUN
bibechana-80853	3	19	of	of	ADP
bibechana-80853	3	20	kalanchoe	kalanchoe	NOUN
bibechana-80853	3	21	pinnata	pinnata	NOUN
bibechana-80853	3	22	(	(	PUNCT
bibechana-80853	3	23	lam	lam	PROPN
bibechana-80853	3	24	.	.	PUNCT
bibechana-80853	3	25	)	)	PUNCT
bibechana-80853	4	1	pers	per	NOUN
bibechana-80853	4	2	.	.	PUNCT
bibechana-80853	5	1	as	as	SCONJ
bibechana-80853	5	2	potential	potential	ADJ
bibechana-80853	5	3	modulators	modulator	NOUN
bibechana-80853	5	4	of	of	ADP
bibechana-80853	5	5	the	the	DET
bibechana-80853	5	6	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	5	7	receptor	receptor	NOUN
bibechana-80853	5	8	against	against	ADP
bibechana-80853	5	9	cardiovascular	cardiovascular	ADJ
bibechana-80853	5	10	diseases	disease	NOUN
bibechana-80853	5	11	ram	ram	VERB
bibechana-80853	5	12	lal	lal	PROPN
bibechana-80853	5	13	(	(	PUNCT
bibechana-80853	5	14	swagat	swagat	ADJ
bibechana-80853	5	15	)	)	PUNCT
bibechana-80853	5	16	shrestha1,2,3	shrestha1,2,3	PROPN
bibechana-80853	5	17	,	,	PUNCT
bibechana-80853	5	18	manila	manila	PROPN
bibechana-80853	5	19	poudel2	poudel2	NOUN
bibechana-80853	5	20	,	,	PUNCT
bibechana-80853	5	21	sujan	sujan	NOUN
bibechana-80853	5	22	dhital1,2	dhital1,2	PROPN
bibechana-80853	5	23	,	,	PUNCT
bibechana-80853	5	24	nirmal	nirmal	ADJ
bibechana-80853	5	25	parajuli	parajuli	NOUN
bibechana-80853	5	26	1,2	1,2	NUM
bibechana-80853	5	27	,	,	PUNCT
bibechana-80853	5	28	ashika	ashika	PROPN
bibechana-80853	5	29	tamang	tamang	PROPN
bibechana-80853	5	30	1,2	1,2	NUM
bibechana-80853	5	31	,	,	PUNCT
bibechana-80853	5	32	safal	safal	VERB
bibechana-80853	5	33	adhikari	adhikari	PROPN
bibechana-80853	5	34	1,2	1,2	NUM
bibechana-80853	5	35	,	,	PUNCT
bibechana-80853	5	36	shiva	shiva	PROPN
bibechana-80853	5	37	m.c	m.c	PROPN
bibechana-80853	5	38	.	.	PROPN
bibechana-80853	5	39	1,2	1,2	NUM
bibechana-80853	5	40	,	,	PUNCT
bibechana-80853	5	41	aakar	aakar	NOUN
bibechana-80853	5	42	shrestha	shrestha	NOUN
bibechana-80853	5	43	2	2	NUM
bibechana-80853	5	44	,	,	PUNCT
bibechana-80853	5	45	timila	timila	NOUN
bibechana-80853	5	46	shrestha	shrestha	PROPN
bibechana-80853	6	1	1,2	1,2	NUM
bibechana-80853	6	2	,	,	PUNCT
bibechana-80853	6	3	samjhana	samjhana	NOUN
bibechana-80853	6	4	bharati	bharati	PROPN
bibechana-80853	6	5	1,2	1,2	NUM
bibechana-80853	6	6	,	,	PUNCT
bibechana-80853	6	7	binita	binita	NOUN
bibechana-80853	6	8	maharjan	maharjan	NOUN
bibechana-80853	6	9	1,2	1,2	NUM
bibechana-80853	6	10	,	,	PUNCT
bibechana-80853	6	11	bishnu	bishnu	PROPN
bibechana-80853	6	12	p.	p.	NOUN
bibechana-80853	6	13	marasini2,3,4	marasini2,3,4	NOUN
bibechana-80853	6	14	,	,	PUNCT
bibechana-80853	6	15	*	*	ADJ
bibechana-80853	6	16	,	,	PUNCT
bibechana-80853	6	17	jhashanath	jhashanath	NOUN
bibechana-80853	6	18	adhikari	adhikari	PROPN
bibechana-80853	6	19	subin	subin	PROPN
bibechana-80853	6	20	2,5	2,5	NUM
bibechana-80853	6	21	,	,	PUNCT
bibechana-80853	6	22	*	*	PROPN
bibechana-80853	6	23	1department	1department	NUM
bibechana-80853	6	24	of	of	ADP
bibechana-80853	6	25	chemistry	chemistry	NOUN
bibechana-80853	6	26	,	,	PUNCT
bibechana-80853	6	27	amrit	amrit	PROPN
bibechana-80853	6	28	campus	campus	PROPN
bibechana-80853	6	29	,	,	PUNCT
bibechana-80853	6	30	tribhuvan	tribhuvan	PROPN
bibechana-80853	6	31	university	university	PROPN
bibechana-80853	6	32	,	,	PUNCT
bibechana-80853	6	33	lainchaur	lainchaur	NOUN
bibechana-80853	6	34	,	,	PUNCT
bibechana-80853	6	35	kathmandu	kathmandu	NOUN
bibechana-80853	6	36	44600	44600	NUM
bibechana-80853	6	37	,	,	PUNCT
bibechana-80853	6	38	nepal	nepal	PROPN
bibechana-80853	6	39	2kathmandu	2kathmandu	NUM
bibechana-80853	6	40	valley	valley	NOUN
bibechana-80853	6	41	college	college	NOUN
bibechana-80853	6	42	,	,	PUNCT
bibechana-80853	6	43	syuchatar	syuchatar	NOUN
bibechana-80853	6	44	bridge	bridge	PROPN
bibechana-80853	6	45	,	,	PUNCT
bibechana-80853	6	46	kalanki	kalanki	PROPN
bibechana-80853	6	47	,	,	PUNCT
bibechana-80853	6	48	kathmandu	kathmandu	PROPN
bibechana-80853	6	49	44600	44600	NUM
bibechana-80853	6	50	,	,	PUNCT
bibechana-80853	6	51	nepal	nepal	NOUN
bibechana-80853	6	52	3institute	3institute	NUM
bibechana-80853	6	53	of	of	ADP
bibechana-80853	6	54	natural	natural	ADJ
bibechana-80853	6	55	resources	resource	NOUN
bibechana-80853	6	56	innovation	innovation	NOUN
bibechana-80853	6	57	,	,	PUNCT
bibechana-80853	6	58	kalimati	kalimati	NOUN
bibechana-80853	6	59	,	,	PUNCT
bibechana-80853	6	60	kathmandu	kathmandu	NOUN
bibechana-80853	6	61	44600	44600	NUM
bibechana-80853	6	62	,	,	PUNCT
bibechana-80853	6	63	nepal	nepal	PROPN
bibechana-80853	6	64	4nepal	4nepal	NUM
bibechana-80853	6	65	health	health	PROPN
bibechana-80853	6	66	research	research	PROPN
bibechana-80853	6	67	council	council	PROPN
bibechana-80853	6	68	,	,	PUNCT
bibechana-80853	6	69	ministry	ministry	PROPN
bibechana-80853	6	70	of	of	ADP
bibechana-80853	6	71	health	health	PROPN
bibechana-80853	6	72	and	and	CCONJ
bibechana-80853	6	73	population	population	NOUN
bibechana-80853	6	74	,	,	PUNCT
bibechana-80853	6	75	ramshah	ramshah	ADJ
bibechana-80853	6	76	path	path	NOUN
bibechana-80853	6	77	,	,	PUNCT
bibechana-80853	6	78	kathmandu	kathmandu	NOUN
bibechana-80853	6	79	44600	44600	NUM
bibechana-80853	6	80	,	,	PUNCT
bibechana-80853	6	81	nepal	nepal	NOUN
bibechana-80853	6	82	5bioinformatics	5bioinformatics	PROPN
bibechana-80853	6	83	and	and	CCONJ
bibechana-80853	6	84	cheminformatics	cheminformatic	NOUN
bibechana-80853	6	85	division	division	NOUN
bibechana-80853	6	86	,	,	PUNCT
bibechana-80853	6	87	scientific	scientific	ADJ
bibechana-80853	6	88	research	research	NOUN
bibechana-80853	6	89	and	and	CCONJ
bibechana-80853	6	90	training	train	VERB
bibechana-80853	6	91	nepal	nepal	PROPN
bibechana-80853	6	92	p.	p.	PROPN
bibechana-80853	6	93	ltd	ltd	PROPN
bibechana-80853	6	94	,	,	PUNCT
bibechana-80853	6	95	bhaktapur	bhaktapur	NOUN
bibechana-80853	6	96	44800	44800	NUM
bibechana-80853	6	97	,	,	PUNCT
bibechana-80853	6	98	nepal	nepal	ADJ
bibechana-80853	6	99	∗corresponding	∗corresponde	VERB
bibechana-80853	6	100	author	author	NOUN
bibechana-80853	6	101	.	.	PUNCT
bibechana-80853	7	1	email	email	NOUN
bibechana-80853	7	2	:	:	PUNCT
bibechana-80853	7	3	bishnu.marasini@gmail.com	bishnu.marasini@gmail.com	X
bibechana-80853	8	1	[	[	X
bibechana-80853	8	2	bpm	bpm	X
bibechana-80853	8	3	]	]	X
bibechana-80853	8	4	subinadhikari2018@gmail.com	subinadhikari2018@gmail.com	PUNCT
bibechana-80853	9	1	[	[	X
bibechana-80853	9	2	jas	jas	X
bibechana-80853	9	3	]	]	X
bibechana-80853	9	4	abstract	abstract	ADJ
bibechana-80853	9	5	cardiovascular	cardiovascular	ADJ
bibechana-80853	9	6	diseases	disease	NOUN
bibechana-80853	9	7	represent	represent	VERB
bibechana-80853	9	8	a	a	DET
bibechana-80853	9	9	leading	lead	VERB
bibechana-80853	9	10	global	global	ADJ
bibechana-80853	9	11	health	health	NOUN
bibechana-80853	9	12	challenge	challenge	NOUN
bibechana-80853	9	13	,	,	PUNCT
bibechana-80853	9	14	with	with	ADP
bibechana-80853	9	15	a	a	DET
bibechana-80853	9	16	pronounced	pronounce	VERB
bibechana-80853	9	17	impact	impact	NOUN
bibechana-80853	9	18	in	in	ADP
bibechana-80853	9	19	low	low	ADJ
bibechana-80853	9	20	and	and	CCONJ
bibechana-80853	9	21	middle	middle	ADJ
bibechana-80853	9	22	-	-	PUNCT
bibechana-80853	9	23	income	income	NOUN
bibechana-80853	9	24	countries	country	NOUN
bibechana-80853	9	25	.	.	PUNCT
bibechana-80853	10	1	the	the	DET
bibechana-80853	10	2	mineralocorticoid	mineralocorticoid	PROPN
bibechana-80853	10	3	receptor	receptor	NOUN
bibechana-80853	10	4	(	(	PUNCT
bibechana-80853	10	5	mr	mr	PROPN
bibechana-80853	10	6	)	)	PUNCT
bibechana-80853	10	7	,	,	PUNCT
bibechana-80853	10	8	a	a	DET
bibechana-80853	10	9	key	key	ADJ
bibechana-80853	10	10	transcription	transcription	NOUN
bibechana-80853	10	11	factor	factor	NOUN
bibechana-80853	10	12	in	in	ADP
bibechana-80853	10	13	cardiovascular	cardiovascular	ADJ
bibechana-80853	10	14	disorders	disorder	NOUN
bibechana-80853	10	15	,	,	PUNCT
bibechana-80853	10	16	has	have	AUX
bibechana-80853	10	17	been	be	AUX
bibechana-80853	10	18	linked	link	VERB
bibechana-80853	10	19	to	to	ADP
bibechana-80853	10	20	hypertension	hypertension	NOUN
bibechana-80853	10	21	,	,	PUNCT
bibechana-80853	10	22	heart	heart	NOUN
bibechana-80853	10	23	failure	failure	NOUN
bibechana-80853	10	24	,	,	PUNCT
bibechana-80853	10	25	and	and	CCONJ
bibechana-80853	10	26	myocardial	myocardial	ADJ
bibechana-80853	10	27	infarction	infarction	NOUN
bibechana-80853	10	28	.	.	PUNCT
bibechana-80853	11	1	this	this	DET
bibechana-80853	11	2	study	study	NOUN
bibechana-80853	11	3	aims	aim	VERB
bibechana-80853	11	4	to	to	PART
bibechana-80853	11	5	investigate	investigate	VERB
bibechana-80853	11	6	the	the	DET
bibechana-80853	11	7	potential	potential	NOUN
bibechana-80853	11	8	of	of	ADP
bibechana-80853	11	9	the	the	DET
bibechana-80853	11	10	phytochemicals	phytochemical	NOUN
bibechana-80853	11	11	in	in	ADP
bibechana-80853	11	12	kalanchoe	kalanchoe	NOUN
bibechana-80853	11	13	pinnata	pinnata	NOUN
bibechana-80853	11	14	(	(	PUNCT
bibechana-80853	11	15	lam	lam	PROPN
bibechana-80853	11	16	.	.	PUNCT
bibechana-80853	11	17	)	)	PUNCT
bibechana-80853	11	18	.	.	PUNCT
bibechana-80853	12	1	pers	per	NOUN
bibechana-80853	12	2	.	.	PUNCT
bibechana-80853	12	3	,	,	PUNCT
bibechana-80853	12	4	a	a	DET
bibechana-80853	12	5	plant	plant	NOUN
bibechana-80853	12	6	known	know	VERB
bibechana-80853	12	7	for	for	ADP
bibechana-80853	12	8	its	its	PRON
bibechana-80853	12	9	traditional	traditional	ADJ
bibechana-80853	12	10	medicinal	medicinal	ADJ
bibechana-80853	12	11	uses	use	NOUN
bibechana-80853	12	12	,	,	PUNCT
bibechana-80853	12	13	in	in	ADP
bibechana-80853	12	14	modulating	modulate	VERB
bibechana-80853	12	15	mr	mr	PROPN
bibechana-80853	12	16	activity	activity	NOUN
bibechana-80853	12	17	through	through	ADP
bibechana-80853	12	18	in	in	ADP
bibechana-80853	12	19	silico	silico	NOUN
bibechana-80853	12	20	approaches	approach	NOUN
bibechana-80853	12	21	.	.	PUNCT
bibechana-80853	13	1	twenty	twenty	NUM
bibechana-80853	13	2	phytochemicals	phytochemical	NOUN
bibechana-80853	13	3	belonging	belong	VERB
bibechana-80853	13	4	to	to	ADP
bibechana-80853	13	5	different	different	ADJ
bibechana-80853	13	6	classes	class	NOUN
bibechana-80853	13	7	of	of	ADP
bibechana-80853	13	8	organic	organic	ADJ
bibechana-80853	13	9	molecules	molecule	NOUN
bibechana-80853	13	10	from	from	ADP
bibechana-80853	13	11	the	the	DET
bibechana-80853	13	12	plant	plant	NOUN
bibechana-80853	13	13	were	be	AUX
bibechana-80853	13	14	subjected	subject	VERB
bibechana-80853	13	15	to	to	ADP
bibechana-80853	13	16	computational	computational	ADJ
bibechana-80853	13	17	screening	screening	NOUN
bibechana-80853	13	18	to	to	PART
bibechana-80853	13	19	assess	assess	VERB
bibechana-80853	13	20	their	their	PRON
bibechana-80853	13	21	interaction	interaction	NOUN
bibechana-80853	13	22	with	with	ADP
bibechana-80853	13	23	the	the	DET
bibechana-80853	13	24	mr	mr	PROPN
bibechana-80853	13	25	(	(	PUNCT
bibechana-80853	13	26	pdb	pdb	PROPN
bibechana-80853	13	27	i	i	PROPN
bibechana-80853	13	28	d	d	PROPN
bibechana-80853	13	29	:	:	PUNCT
bibechana-80853	13	30	5l7e	5l7e	NOUN
bibechana-80853	13	31	)	)	PUNCT
bibechana-80853	13	32	.	.	PUNCT
bibechana-80853	14	1	mr	mr	PROPN
bibechana-80853	14	2	was	be	AUX
bibechana-80853	14	3	treated	treat	VERB
bibechana-80853	14	4	as	as	ADP
bibechana-80853	14	5	a	a	DET
bibechana-80853	14	6	flexible	flexible	ADJ
bibechana-80853	14	7	receptor	receptor	NOUN
bibechana-80853	14	8	,	,	PUNCT
bibechana-80853	14	9	and	and	CCONJ
bibechana-80853	14	10	molecular	molecular	ADJ
bibechana-80853	14	11	docking	docking	NOUN
bibechana-80853	14	12	was	be	AUX
bibechana-80853	14	13	performed	perform	VERB
bibechana-80853	14	14	in	in	ADP
bibechana-80853	14	15	a	a	DET
bibechana-80853	14	16	solvated	solvate	VERB
bibechana-80853	14	17	environment	environment	NOUN
bibechana-80853	14	18	.	.	PUNCT
bibechana-80853	15	1	the	the	DET
bibechana-80853	15	2	molecule	molecule	NOUN
bibechana-80853	15	3	astragalin	astragalin	NOUN
bibechana-80853	15	4	among	among	ADP
bibechana-80853	15	5	the	the	DET
bibechana-80853	15	6	test	test	NOUN
bibechana-80853	15	7	molecules	molecule	NOUN
bibechana-80853	15	8	showed	show	VERB
bibechana-80853	15	9	a	a	DET
bibechana-80853	15	10	promising	promising	ADJ
bibechana-80853	15	11	binding	bind	VERB
bibechana-80853	15	12	score	score	NOUN
bibechana-80853	15	13	of	of	ADP
bibechana-80853	15	14	-9.209	-9.209	PROPN
bibechana-80853	15	15	kcal	kcal	PROPN
bibechana-80853	15	16	/	/	SYM
bibechana-80853	15	17	mol	mol	PROPN
bibechana-80853	15	18	,	,	PUNCT
bibechana-80853	15	19	which	which	PRON
bibechana-80853	15	20	is	be	AUX
bibechana-80853	15	21	comparable	comparable	ADJ
bibechana-80853	15	22	to	to	ADP
bibechana-80853	15	23	the	the	DET
bibechana-80853	15	24	native	native	ADJ
bibechana-80853	15	25	ligand	ligand	NOUN
bibechana-80853	15	26	's	's	PART
bibechana-80853	15	27	score	score	NOUN
bibechana-80853	15	28	of	of	ADP
bibechana-80853	15	29	-9.619	-9.619	NUM
bibechana-80853	15	30	kcal	kcal	PROPN
bibechana-80853	15	31	/	/	SYM
bibechana-80853	15	32	mol	mol	PROPN
bibechana-80853	15	33	.	.	PUNCT
bibechana-80853	16	1	admet	admet	PROPN
bibechana-80853	16	2	predictions	prediction	NOUN
bibechana-80853	16	3	,	,	PUNCT
bibechana-80853	16	4	including	include	VERB
bibechana-80853	16	5	toxicity	toxicity	NOUN
bibechana-80853	16	6	classification	classification	NOUN
bibechana-80853	16	7	,	,	PUNCT
bibechana-80853	16	8	revealed	reveal	VERB
bibechana-80853	16	9	that	that	SCONJ
bibechana-80853	16	10	most	most	ADJ
bibechana-80853	16	11	of	of	ADP
bibechana-80853	16	12	the	the	DET
bibechana-80853	16	13	compounds	compound	NOUN
bibechana-80853	16	14	demonstrated	demonstrate	VERB
bibechana-80853	16	15	favorable	favorable	ADJ
bibechana-80853	16	16	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	16	17	absorption	absorption	NOUN
bibechana-80853	16	18	and	and	CCONJ
bibechana-80853	16	19	varying	vary	VERB
bibechana-80853	16	20	degrees	degree	NOUN
bibechana-80853	16	21	of	of	ADP
bibechana-80853	16	22	blood	blood	NOUN
bibechana-80853	16	23	-	-	PUNCT
bibechana-80853	16	24	brain	brain	NOUN
bibechana-80853	16	25	barrier	barrier	NOUN
bibechana-80853	16	26	permeability	permeability	NOUN
bibechana-80853	16	27	.	.	PUNCT
bibechana-80853	17	1	toxicity	toxicity	NOUN
bibechana-80853	17	2	evaluations	evaluation	NOUN
bibechana-80853	17	3	revealed	reveal	VERB
bibechana-80853	17	4	that	that	SCONJ
bibechana-80853	17	5	several	several	ADJ
bibechana-80853	17	6	compounds	compound	NOUN
bibechana-80853	17	7	exhibited	exhibit	VERB
bibechana-80853	17	8	moderate	moderate	ADJ
bibechana-80853	17	9	to	to	ADP
bibechana-80853	17	10	low	low	ADJ
bibechana-80853	17	11	toxicity	toxicity	NOUN
bibechana-80853	17	12	,	,	PUNCT
bibechana-80853	17	13	with	with	ADP
bibechana-80853	17	14	both	both	CCONJ
bibechana-80853	17	15	astragalin	astragalin	PROPN
bibechana-80853	17	16	and	and	CCONJ
bibechana-80853	17	17	patuletin	patuletin	NOUN
bibechana-80853	17	18	classified	classify	VERB
bibechana-80853	17	19	as	as	ADP
bibechana-80853	17	20	class	class	NOUN
bibechana-80853	17	21	5	5	NUM
bibechana-80853	17	22	,	,	PUNCT
bibechana-80853	17	23	indicating	indicate	VERB
bibechana-80853	17	24	a	a	DET
bibechana-80853	17	25	relatively	relatively	ADV
bibechana-80853	17	26	higher	high	ADJ
bibechana-80853	17	27	level	level	NOUN
bibechana-80853	17	28	of	of	ADP
bibechana-80853	17	29	safety	safety	NOUN
bibechana-80853	17	30	compared	compare	VERB
bibechana-80853	17	31	to	to	ADP
bibechana-80853	17	32	other	other	ADJ
bibechana-80853	17	33	phytochemicals	phytochemical	NOUN
bibechana-80853	17	34	,	,	PUNCT
bibechana-80853	17	35	and	and	CCONJ
bibechana-80853	17	36	a	a	DET
bibechana-80853	17	37	class	class	NOUN
bibechana-80853	17	38	comparable	comparable	ADJ
bibechana-80853	17	39	to	to	ADP
bibechana-80853	17	40	the	the	DET
bibechana-80853	17	41	native	native	ADJ
bibechana-80853	17	42	compound	compound	NOUN
bibechana-80853	17	43	(	(	PUNCT
bibechana-80853	17	44	class	class	NOUN
bibechana-80853	17	45	6	6	NUM
bibechana-80853	17	46	)	)	PUNCT
bibechana-80853	17	47	.	.	PUNCT
bibechana-80853	18	1	these	these	DET
bibechana-80853	18	2	findings	finding	NOUN
bibechana-80853	18	3	suggested	suggest	VERB
bibechana-80853	18	4	that	that	SCONJ
bibechana-80853	18	5	phytochemicals	phytochemical	NOUN
bibechana-80853	18	6	of	of	ADP
bibechana-80853	18	7	k.	k.	PROPN
bibechana-80853	18	8	pinnata	pinnata	PROPN
bibechana-80853	18	9	hold	hold	VERB
bibechana-80853	18	10	potential	potential	NOUN
bibechana-80853	18	11	for	for	ADP
bibechana-80853	18	12	further	further	ADJ
bibechana-80853	18	13	investigation	investigation	NOUN
bibechana-80853	18	14	as	as	ADP
bibechana-80853	18	15	modulators	modulator	NOUN
bibechana-80853	18	16	of	of	ADP
bibechana-80853	18	17	mr	mr	PROPN
bibechana-80853	18	18	activity	activity	NOUN
bibechana-80853	18	19	,	,	PUNCT
bibechana-80853	18	20	with	with	ADP
bibechana-80853	18	21	implications	implication	NOUN
bibechana-80853	18	22	for	for	ADP
bibechana-80853	18	23	drug	drug	NOUN
bibechana-80853	18	24	development	development	NOUN
bibechana-80853	18	25	in	in	ADP
bibechana-80853	18	26	cardiovascular	cardiovascular	ADJ
bibechana-80853	18	27	diseases	disease	NOUN
bibechana-80853	18	28	.	.	PUNCT
bibechana-80853	19	1	keywords	keyword	NOUN
bibechana-80853	19	2	:	:	PUNCT
bibechana-80853	19	3	flexible	flexible	ADJ
bibechana-80853	19	4	molecular	molecular	ADJ
bibechana-80853	19	5	docking	docking	NOUN
bibechana-80853	19	6	,	,	PUNCT
bibechana-80853	19	7	computational	computational	ADJ
bibechana-80853	19	8	approach	approach	NOUN
bibechana-80853	19	9	,	,	PUNCT
bibechana-80853	19	10	desolvation	desolvation	NOUN
bibechana-80853	19	11	,	,	PUNCT
bibechana-80853	19	12	docking	docking	NOUN
bibechana-80853	19	13	score	score	NOUN
bibechana-80853	19	14	,	,	PUNCT
bibechana-80853	19	15	pharmacokinetics	pharmacokinetic	NOUN
bibechana-80853	19	16	,	,	PUNCT
bibechana-80853	19	17	drug	drug	NOUN
bibechana-80853	19	18	-	-	PUNCT
bibechana-80853	19	19	likeness	likeness	NOUN
bibechana-80853	19	20	.	.	PUNCT
bibechana-80853	20	1	article	article	NOUN
bibechana-80853	20	2	information	information	PROPN
bibechana-80853	20	3	manuscript	manuscript	PROPN
bibechana-80853	20	4	received	receive	VERB
bibechana-80853	20	5	:	:	PUNCT
bibechana-80853	20	6	july	july	PROPN
bibechana-80853	20	7	1	1	NUM
bibechana-80853	20	8	,	,	PUNCT
bibechana-80853	20	9	2025	2025	NUM
bibechana-80853	20	10	;	;	PUNCT
bibechana-80853	20	11	revised	revise	VERB
bibechana-80853	20	12	:	:	PUNCT
bibechana-80853	20	13	august	august	PROPN
bibechana-80853	20	14	29	29	NUM
bibechana-80853	20	15	,	,	PUNCT
bibechana-80853	20	16	2025	2025	NUM
bibechana-80853	20	17	;	;	PUNCT
bibechana-80853	20	18	accepted	accept	VERB
bibechana-80853	20	19	:	:	PUNCT
bibechana-80853	20	20	september	september	PROPN
bibechana-80853	20	21	11	11	NUM
bibechana-80853	20	22	,	,	PUNCT
bibechana-80853	20	23	2025	2025	NUM
bibechana-80853	20	24	doi	doi	X
bibechana-80853	20	25	https://doi.org/10.3126/bibechana.v22i3.80853	https://doi.org/10.3126/bibechana.v22i3.80853	NOUN
bibechana-80853	20	26	this	this	DET
bibechana-80853	20	27	work	work	NOUN
bibechana-80853	20	28	is	be	AUX
bibechana-80853	20	29	licensed	license	VERB
bibechana-80853	20	30	under	under	ADP
bibechana-80853	20	31	the	the	DET
bibechana-80853	20	32	creative	creative	ADJ
bibechana-80853	20	33	commons	common	NOUN
bibechana-80853	20	34	cc	cc	ADP
bibechana-80853	20	35	by	by	ADP
bibechana-80853	20	36	-	-	PUNCT
bibechana-80853	20	37	nc	nc	NOUN
bibechana-80853	20	38	license	license	NOUN
bibechana-80853	20	39	.	.	PUNCT
bibechana-80853	21	1	https://creativecommons	https://creativecommon	NOUN
bibechana-80853	21	2	.	.	PUNCT
bibechana-80853	21	3	org	org	ADJ
bibechana-80853	21	4	/	/	SYM
bibechana-80853	21	5	licenses	license	NOUN
bibechana-80853	21	6	/	/	SYM
bibechana-80853	21	7	by	by	ADP
bibechana-80853	21	8	-	-	PUNCT
bibechana-80853	21	9	nc/4.0/	nc/4.0/	NOUN
bibechana-80853	21	10	291	291	NUM
bibechana-80853	21	11	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	NOUN
bibechana-80853	21	12	bishnu.marasini@gmail.com	bishnu.marasini@gmail.com	X
bibechana-80853	21	13	subinadhikari2018@gmail.com	subinadhikari2018@gmail.com	X
bibechana-80853	21	14	https://doi.org/10.3126/bibechana.v22i3.80853	https://doi.org/10.3126/bibechana.v22i3.80853	X
bibechana-80853	21	15	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	ADP
bibechana-80853	21	16	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PRON
bibechana-80853	21	17	ram	ram	NOUN
bibechana-80853	21	18	lal	lal	PROPN
bibechana-80853	21	19	(	(	PUNCT
bibechana-80853	21	20	swagat	swagat	ADJ
bibechana-80853	21	21	)	)	PUNCT
bibechana-80853	21	22	shrestha	shrestha	NOUN
bibechana-80853	21	23	et	et	PROPN
bibechana-80853	21	24	al./	al./	ADV
bibechana-80853	21	25	bibechana	bibechana	PROPN
bibechana-80853	21	26	22	22	NUM
bibechana-80853	21	27	(	(	PUNCT
bibechana-80853	21	28	2025	2025	NUM
bibechana-80853	21	29	)	)	PUNCT
bibechana-80853	21	30	291	291	NUM
bibechana-80853	21	31	-	-	SYM
bibechana-80853	21	32	298	298	NUM
bibechana-80853	21	33	292	292	NUM
bibechana-80853	21	34	1	1	NUM
bibechana-80853	21	35	introduction	introduction	NOUN
bibechana-80853	21	36	cardiovascular	cardiovascular	ADJ
bibechana-80853	21	37	(	(	PUNCT
bibechana-80853	21	38	cv	cv	NOUN
bibechana-80853	21	39	)	)	PUNCT
bibechana-80853	21	40	disease	disease	NOUN
bibechana-80853	21	41	refers	refer	VERB
bibechana-80853	21	42	to	to	ADP
bibechana-80853	21	43	a	a	DET
bibechana-80853	21	44	group	group	NOUN
bibechana-80853	21	45	of	of	ADP
bibechana-80853	21	46	conditions	condition	NOUN
bibechana-80853	21	47	that	that	PRON
bibechana-80853	21	48	affect	affect	VERB
bibechana-80853	21	49	the	the	DET
bibechana-80853	21	50	heart	heart	NOUN
bibechana-80853	21	51	and	and	CCONJ
bibechana-80853	21	52	blood	blood	NOUN
bibechana-80853	21	53	vessels	vessel	NOUN
bibechana-80853	21	54	.	.	PUNCT
bibechana-80853	22	1	this	this	PRON
bibechana-80853	22	2	includes	include	VERB
bibechana-80853	22	3	hypertension	hypertension	NOUN
bibechana-80853	22	4	,	,	PUNCT
bibechana-80853	22	5	heart	heart	NOUN
bibechana-80853	22	6	attack	attack	NOUN
bibechana-80853	22	7	,	,	PUNCT
bibechana-80853	22	8	stroke	stroke	NOUN
bibechana-80853	22	9	,	,	PUNCT
bibechana-80853	22	10	heart	heart	NOUN
bibechana-80853	22	11	failure	failure	NOUN
bibechana-80853	22	12	,	,	PUNCT
bibechana-80853	22	13	and	and	CCONJ
bibechana-80853	22	14	other	other	ADJ
bibechana-80853	22	15	heart	heart	NOUN
bibechana-80853	22	16	disorders	disorder	NOUN
bibechana-80853	22	17	[	[	X
bibechana-80853	22	18	1	1	NUM
bibechana-80853	22	19	]	]	PUNCT
bibechana-80853	22	20	.	.	PUNCT
bibechana-80853	23	1	cv	cv	PROPN
bibechana-80853	23	2	disease	disease	NOUN
bibechana-80853	23	3	is	be	AUX
bibechana-80853	23	4	the	the	DET
bibechana-80853	23	5	leading	lead	VERB
bibechana-80853	23	6	cause	cause	NOUN
bibechana-80853	23	7	of	of	ADP
bibechana-80853	23	8	death	death	NOUN
bibechana-80853	23	9	worldwide	worldwide	ADV
bibechana-80853	23	10	,	,	PUNCT
bibechana-80853	23	11	disproportionately	disproportionately	ADV
bibechana-80853	23	12	affecting	affect	VERB
bibechana-80853	23	13	lowand	lowand	ADJ
bibechana-80853	23	14	middle	middle	ADJ
bibechana-80853	23	15	-	-	PUNCT
bibechana-80853	23	16	income	income	NOUN
bibechana-80853	23	17	countries	country	NOUN
bibechana-80853	23	18	more	more	ADV
bibechana-80853	23	19	severely	severely	ADV
bibechana-80853	23	20	than	than	ADP
bibechana-80853	23	21	high	high	ADJ
bibechana-80853	23	22	-	-	PUNCT
bibechana-80853	23	23	income	income	NOUN
bibechana-80853	23	24	countries	country	NOUN
bibechana-80853	23	25	[	[	X
bibechana-80853	23	26	2	2	NUM
bibechana-80853	23	27	,	,	PUNCT
bibechana-80853	23	28	3	3	NUM
bibechana-80853	23	29	]	]	PUNCT
bibechana-80853	23	30	.	.	PUNCT
bibechana-80853	24	1	the	the	DET
bibechana-80853	24	2	mineralocorticoid	mineralocorticoid	PROPN
bibechana-80853	24	3	receptor	receptor	NOUN
bibechana-80853	24	4	(	(	PUNCT
bibechana-80853	24	5	mr	mr	PROPN
bibechana-80853	24	6	)	)	PUNCT
bibechana-80853	24	7	is	be	AUX
bibechana-80853	24	8	a	a	DET
bibechana-80853	24	9	transcription	transcription	NOUN
bibechana-80853	24	10	factor	factor	NOUN
bibechana-80853	24	11	belonging	belong	VERB
bibechana-80853	24	12	to	to	ADP
bibechana-80853	24	13	the	the	DET
bibechana-80853	24	14	steroid	steroid	NOUN
bibechana-80853	24	15	receptor	receptor	NOUN
bibechana-80853	24	16	family	family	NOUN
bibechana-80853	24	17	.	.	PUNCT
bibechana-80853	25	1	activation	activation	NOUN
bibechana-80853	25	2	of	of	ADP
bibechana-80853	25	3	the	the	DET
bibechana-80853	25	4	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	25	5	receptor	receptor	NOUN
bibechana-80853	25	6	is	be	AUX
bibechana-80853	25	7	associated	associate	VERB
bibechana-80853	25	8	with	with	ADP
bibechana-80853	25	9	various	various	ADJ
bibechana-80853	25	10	cv	cv	ADJ
bibechana-80853	25	11	system	system	NOUN
bibechana-80853	25	12	disorders	disorder	NOUN
bibechana-80853	25	13	,	,	PUNCT
bibechana-80853	25	14	such	such	ADJ
bibechana-80853	25	15	as	as	ADP
bibechana-80853	25	16	hypertension	hypertension	NOUN
bibechana-80853	25	17	,	,	PUNCT
bibechana-80853	25	18	heart	heart	NOUN
bibechana-80853	25	19	failure	failure	NOUN
bibechana-80853	25	20	,	,	PUNCT
bibechana-80853	25	21	and	and	CCONJ
bibechana-80853	25	22	myocardial	myocardial	ADJ
bibechana-80853	25	23	infarction	infarction	NOUN
bibechana-80853	25	24	[	[	X
bibechana-80853	25	25	4	4	NUM
bibechana-80853	25	26	,	,	PUNCT
bibechana-80853	25	27	5	5	NUM
bibechana-80853	25	28	]	]	PUNCT
bibechana-80853	25	29	.	.	PUNCT
bibechana-80853	26	1	the	the	DET
bibechana-80853	26	2	increase	increase	NOUN
bibechana-80853	26	3	in	in	ADP
bibechana-80853	26	4	mr	mr	PROPN
bibechana-80853	26	5	expression	expression	NOUN
bibechana-80853	26	6	in	in	ADP
bibechana-80853	26	7	the	the	DET
bibechana-80853	26	8	heart	heart	NOUN
bibechana-80853	26	9	and	and	CCONJ
bibechana-80853	26	10	blood	blood	NOUN
bibechana-80853	26	11	vessels	vessel	NOUN
bibechana-80853	26	12	with	with	ADP
bibechana-80853	26	13	age	age	NOUN
bibechana-80853	26	14	contributes	contribute	VERB
bibechana-80853	26	15	to	to	ADP
bibechana-80853	26	16	the	the	DET
bibechana-80853	26	17	higher	high	ADJ
bibechana-80853	26	18	incidence	incidence	NOUN
bibechana-80853	26	19	of	of	ADP
bibechana-80853	26	20	cv	cv	NOUN
bibechana-80853	26	21	diseases	disease	NOUN
bibechana-80853	26	22	in	in	ADP
bibechana-80853	26	23	the	the	DET
bibechana-80853	26	24	elderly	elderly	ADJ
bibechana-80853	26	25	[	[	X
bibechana-80853	26	26	6	6	NUM
bibechana-80853	26	27	,	,	PUNCT
bibechana-80853	26	28	7	7	NUM
bibechana-80853	26	29	]	]	PUNCT
bibechana-80853	26	30	.	.	PUNCT
bibechana-80853	27	1	enalapril	enalapril	PROPN
bibechana-80853	27	2	and	and	CCONJ
bibechana-80853	27	3	metoprolol	metoprolol	PROPN
bibechana-80853	27	4	are	be	AUX
bibechana-80853	27	5	frequently	frequently	ADV
bibechana-80853	27	6	prescribed	prescribe	VERB
bibechana-80853	27	7	for	for	ADP
bibechana-80853	27	8	the	the	DET
bibechana-80853	27	9	treatment	treatment	NOUN
bibechana-80853	27	10	of	of	ADP
bibechana-80853	27	11	cv	cv	PROPN
bibechana-80853	27	12	conditions	condition	NOUN
bibechana-80853	27	13	like	like	ADP
bibechana-80853	27	14	hypertension	hypertension	NOUN
bibechana-80853	27	15	and	and	CCONJ
bibechana-80853	27	16	heart	heart	NOUN
bibechana-80853	27	17	failure	failure	NOUN
bibechana-80853	27	18	.	.	PUNCT
bibechana-80853	28	1	despite	despite	SCONJ
bibechana-80853	28	2	their	their	PRON
bibechana-80853	28	3	effectiveness	effectiveness	NOUN
bibechana-80853	28	4	,	,	PUNCT
bibechana-80853	28	5	these	these	DET
bibechana-80853	28	6	drugs	drug	NOUN
bibechana-80853	28	7	may	may	AUX
bibechana-80853	28	8	cause	cause	VERB
bibechana-80853	28	9	side	side	NOUN
bibechana-80853	28	10	effects	effect	NOUN
bibechana-80853	28	11	,	,	PUNCT
bibechana-80853	28	12	including	include	VERB
bibechana-80853	28	13	dizziness	dizziness	NOUN
bibechana-80853	28	14	,	,	PUNCT
bibechana-80853	28	15	headaches	headache	NOUN
bibechana-80853	28	16	,	,	PUNCT
bibechana-80853	28	17	weakness	weakness	NOUN
bibechana-80853	28	18	,	,	PUNCT
bibechana-80853	28	19	a	a	DET
bibechana-80853	28	20	drastic	drastic	ADJ
bibechana-80853	28	21	decrease	decrease	NOUN
bibechana-80853	28	22	in	in	ADP
bibechana-80853	28	23	white	white	ADJ
bibechana-80853	28	24	blood	blood	NOUN
bibechana-80853	28	25	cell	cell	NOUN
bibechana-80853	28	26	count	count	NOUN
bibechana-80853	28	27	,	,	PUNCT
bibechana-80853	28	28	proteinuria	proteinuria	NOUN
bibechana-80853	28	29	,	,	PUNCT
bibechana-80853	28	30	and	and	CCONJ
bibechana-80853	28	31	severe	severe	ADJ
bibechana-80853	28	32	allergic	allergic	ADJ
bibechana-80853	28	33	reactions	reaction	NOUN
bibechana-80853	28	34	.	.	PUNCT
bibechana-80853	29	1	to	to	PART
bibechana-80853	29	2	address	address	VERB
bibechana-80853	29	3	these	these	DET
bibechana-80853	29	4	issues	issue	NOUN
bibechana-80853	29	5	,	,	PUNCT
bibechana-80853	29	6	this	this	DET
bibechana-80853	29	7	study	study	NOUN
bibechana-80853	29	8	focuses	focus	VERB
bibechana-80853	29	9	on	on	ADP
bibechana-80853	29	10	exploring	explore	VERB
bibechana-80853	29	11	plant	plant	NOUN
bibechana-80853	29	12	-	-	PUNCT
bibechana-80853	29	13	based	base	VERB
bibechana-80853	29	14	compounds	compound	NOUN
bibechana-80853	29	15	as	as	ADP
bibechana-80853	29	16	potential	potential	ADJ
bibechana-80853	29	17	alternatives	alternative	NOUN
bibechana-80853	29	18	[	[	X
bibechana-80853	29	19	8	8	NUM
bibechana-80853	29	20	,	,	PUNCT
bibechana-80853	29	21	9	9	NUM
bibechana-80853	29	22	]	]	PUNCT
bibechana-80853	29	23	.	.	PUNCT
bibechana-80853	30	1	medicinal	medicinal	ADJ
bibechana-80853	30	2	plants	plant	NOUN
bibechana-80853	30	3	are	be	AUX
bibechana-80853	30	4	recognized	recognize	VERB
bibechana-80853	30	5	for	for	ADP
bibechana-80853	30	6	containing	contain	VERB
bibechana-80853	30	7	compounds	compound	NOUN
bibechana-80853	30	8	that	that	PRON
bibechana-80853	30	9	may	may	AUX
bibechana-80853	30	10	be	be	AUX
bibechana-80853	30	11	valuable	valuable	ADJ
bibechana-80853	30	12	in	in	ADP
bibechana-80853	30	13	treating	treat	VERB
bibechana-80853	30	14	diseases	disease	NOUN
bibechana-80853	30	15	or	or	CCONJ
bibechana-80853	30	16	in	in	ADP
bibechana-80853	30	17	drug	drug	NOUN
bibechana-80853	30	18	development	development	NOUN
bibechana-80853	30	19	[	[	X
bibechana-80853	30	20	10	10	NUM
bibechana-80853	30	21	,	,	PUNCT
bibechana-80853	30	22	11	11	NUM
bibechana-80853	30	23	]	]	PUNCT
bibechana-80853	30	24	.	.	PUNCT
bibechana-80853	31	1	kalanchoe	kalanchoe	NOUN
bibechana-80853	31	2	pinnata	pinnata	NOUN
bibechana-80853	31	3	(	(	PUNCT
bibechana-80853	31	4	lam	lam	PROPN
bibechana-80853	31	5	.	.	PUNCT
bibechana-80853	31	6	)	)	PUNCT
bibechana-80853	32	1	pers	per	NOUN
bibechana-80853	32	2	.	.	PUNCT
bibechana-80853	32	3	,	,	PUNCT
bibechana-80853	32	4	a	a	DET
bibechana-80853	32	5	succulent	succulent	ADJ
bibechana-80853	32	6	herb	herb	NOUN
bibechana-80853	32	7	,	,	PUNCT
bibechana-80853	32	8	has	have	AUX
bibechana-80853	32	9	long	long	ADV
bibechana-80853	32	10	been	be	AUX
bibechana-80853	32	11	utilized	utilize	VERB
bibechana-80853	32	12	in	in	ADP
bibechana-80853	32	13	traditional	traditional	ADJ
bibechana-80853	32	14	medicine	medicine	NOUN
bibechana-80853	32	15	to	to	PART
bibechana-80853	32	16	treat	treat	VERB
bibechana-80853	32	17	heart	heart	NOUN
bibechana-80853	32	18	conditions	condition	NOUN
bibechana-80853	32	19	,	,	PUNCT
bibechana-80853	32	20	kidney	kidney	NOUN
bibechana-80853	32	21	stones	stone	NOUN
bibechana-80853	32	22	,	,	PUNCT
bibechana-80853	32	23	and	and	CCONJ
bibechana-80853	32	24	cancer	cancer	NOUN
bibechana-80853	33	1	[	[	X
bibechana-80853	33	2	12	12	NUM
bibechana-80853	33	3	,	,	PUNCT
bibechana-80853	33	4	13	13	NUM
bibechana-80853	33	5	]	]	PUNCT
bibechana-80853	33	6	.	.	PUNCT
bibechana-80853	34	1	they	they	PRON
bibechana-80853	34	2	are	be	AUX
bibechana-80853	34	3	used	use	VERB
bibechana-80853	34	4	in	in	ADP
bibechana-80853	34	5	folk	folk	NOUN
bibechana-80853	34	6	medicine	medicine	NOUN
bibechana-80853	34	7	to	to	PART
bibechana-80853	34	8	relieve	relieve	VERB
bibechana-80853	34	9	stomach	stomach	NOUN
bibechana-80853	34	10	pain	pain	NOUN
bibechana-80853	34	11	and	and	CCONJ
bibechana-80853	34	12	to	to	PART
bibechana-80853	34	13	treat	treat	VERB
bibechana-80853	34	14	gastritis	gastritis	NOUN
bibechana-80853	34	15	,	,	PUNCT
bibechana-80853	34	16	diarrhea	diarrhea	PROPN
bibechana-80853	34	17	,	,	PUNCT
bibechana-80853	34	18	dysmenorrhea	dysmenorrhea	NOUN
bibechana-80853	34	19	,	,	PUNCT
bibechana-80853	34	20	liver	liver	NOUN
bibechana-80853	34	21	disorders	disorder	NOUN
bibechana-80853	34	22	,	,	PUNCT
bibechana-80853	34	23	fever	fever	NOUN
bibechana-80853	34	24	,	,	PUNCT
bibechana-80853	34	25	female	female	ADJ
bibechana-80853	34	26	infertility	infertility	NOUN
bibechana-80853	34	27	,	,	PUNCT
bibechana-80853	34	28	genitourinary	genitourinary	ADJ
bibechana-80853	34	29	infections	infection	NOUN
bibechana-80853	34	30	,	,	PUNCT
bibechana-80853	34	31	snake	snake	NOUN
bibechana-80853	34	32	and	and	CCONJ
bibechana-80853	34	33	scorpion	scorpion	NOUN
bibechana-80853	34	34	bites	bite	NOUN
bibechana-80853	34	35	,	,	PUNCT
bibechana-80853	34	36	leprosy	leprosy	NOUN
bibechana-80853	34	37	,	,	PUNCT
bibechana-80853	34	38	cough	cough	NOUN
bibechana-80853	34	39	,	,	PUNCT
bibechana-80853	34	40	asthma	asthma	NOUN
bibechana-80853	34	41	,	,	PUNCT
bibechana-80853	34	42	kidney	kidney	NOUN
bibechana-80853	34	43	stones	stone	NOUN
bibechana-80853	34	44	,	,	PUNCT
bibechana-80853	34	45	arthritis	arthritis	NOUN
bibechana-80853	34	46	,	,	PUNCT
bibechana-80853	34	47	cv	cv	NOUN
bibechana-80853	34	48	diseases	disease	NOUN
bibechana-80853	34	49	,	,	PUNCT
bibechana-80853	34	50	and	and	CCONJ
bibechana-80853	34	51	general	general	ADJ
bibechana-80853	34	52	tiredness	tiredness	NOUN
bibechana-80853	34	53	[	[	X
bibechana-80853	34	54	14	14	NUM
bibechana-80853	34	55	]	]	PUNCT
bibechana-80853	34	56	.	.	PUNCT
bibechana-80853	35	1	the	the	DET
bibechana-80853	35	2	plant	plant	NOUN
bibechana-80853	35	3	extract	extract	NOUN
bibechana-80853	35	4	exhibits	exhibit	VERB
bibechana-80853	35	5	antihypertensive	antihypertensive	ADJ
bibechana-80853	35	6	activity	activity	NOUN
bibechana-80853	35	7	as	as	SCONJ
bibechana-80853	35	8	reported	report	VERB
bibechana-80853	35	9	by	by	ADP
bibechana-80853	35	10	various	various	ADJ
bibechana-80853	35	11	authors	author	NOUN
bibechana-80853	35	12	[	[	X
bibechana-80853	35	13	15,16	15,16	NUM
bibechana-80853	35	14	]	]	PUNCT
bibechana-80853	35	15	,	,	PUNCT
bibechana-80853	35	16	and	and	CCONJ
bibechana-80853	35	17	forms	form	VERB
bibechana-80853	35	18	the	the	DET
bibechana-80853	35	19	premise	premise	NOUN
bibechana-80853	35	20	for	for	ADP
bibechana-80853	35	21	this	this	DET
bibechana-80853	35	22	work	work	NOUN
bibechana-80853	35	23	.	.	PUNCT
bibechana-80853	36	1	discovering	discover	VERB
bibechana-80853	36	2	new	new	ADJ
bibechana-80853	36	3	leads	lead	NOUN
bibechana-80853	36	4	for	for	ADP
bibechana-80853	36	5	a	a	DET
bibechana-80853	36	6	well	well	ADV
bibechana-80853	36	7	-	-	PUNCT
bibechana-80853	36	8	known	know	VERB
bibechana-80853	36	9	target	target	NOUN
bibechana-80853	36	10	is	be	AUX
bibechana-80853	36	11	a	a	DET
bibechana-80853	36	12	pivotal	pivotal	ADJ
bibechana-80853	36	13	phase	phase	NOUN
bibechana-80853	36	14	in	in	ADP
bibechana-80853	36	15	drug	drug	NOUN
bibechana-80853	36	16	development	development	NOUN
bibechana-80853	36	17	.	.	PUNCT
bibechana-80853	37	1	two	two	NUM
bibechana-80853	37	2	primary	primary	ADJ
bibechana-80853	37	3	approaches	approach	NOUN
bibechana-80853	37	4	are	be	AUX
bibechana-80853	37	5	employed	employ	VERB
bibechana-80853	37	6	:	:	PUNCT
bibechana-80853	37	7	experimental	experimental	ADJ
bibechana-80853	37	8	highthroughput	highthroughput	NOUN
bibechana-80853	37	9	screening	screen	VERB
bibechana-80853	37	10	to	to	PART
bibechana-80853	37	11	sift	sift	VERB
bibechana-80853	37	12	through	through	ADP
bibechana-80853	37	13	extensive	extensive	ADJ
bibechana-80853	37	14	compound	compound	NOUN
bibechana-80853	37	15	libraries	library	NOUN
bibechana-80853	37	16	for	for	ADP
bibechana-80853	37	17	potential	potential	ADJ
bibechana-80853	37	18	leads	lead	NOUN
bibechana-80853	37	19	,	,	PUNCT
bibechana-80853	37	20	and	and	CCONJ
bibechana-80853	37	21	computational	computational	ADJ
bibechana-80853	37	22	methods	method	NOUN
bibechana-80853	37	23	that	that	PRON
bibechana-80853	37	24	leverage	leverage	VERB
bibechana-80853	37	25	structural	structural	ADJ
bibechana-80853	37	26	data	datum	NOUN
bibechana-80853	37	27	of	of	ADP
bibechana-80853	37	28	the	the	DET
bibechana-80853	37	29	protein	protein	NOUN
bibechana-80853	37	30	binding	bind	VERB
bibechana-80853	37	31	site	site	NOUN
bibechana-80853	37	32	[	[	X
bibechana-80853	37	33	17	17	NUM
bibechana-80853	37	34	]	]	PUNCT
bibechana-80853	37	35	.	.	PUNCT
bibechana-80853	38	1	to	to	PART
bibechana-80853	38	2	reduce	reduce	VERB
bibechana-80853	38	3	the	the	DET
bibechana-80853	38	4	cost	cost	NOUN
bibechana-80853	38	5	and	and	CCONJ
bibechana-80853	38	6	time	time	NOUN
bibechana-80853	38	7	associated	associate	VERB
bibechana-80853	38	8	with	with	ADP
bibechana-80853	38	9	extensive	extensive	ADJ
bibechana-80853	38	10	in	in	ADP
bibechana-80853	38	11	vitro	vitro	X
bibechana-80853	38	12	and	and	CCONJ
bibechana-80853	38	13	in	in	ADP
bibechana-80853	38	14	vivo	vivo	ADJ
bibechana-80853	38	15	experiments	experiment	NOUN
bibechana-80853	38	16	for	for	ADP
bibechana-80853	38	17	identifying	identify	VERB
bibechana-80853	38	18	potential	potential	ADJ
bibechana-80853	38	19	compounds	compound	NOUN
bibechana-80853	38	20	in	in	ADP
bibechana-80853	38	21	drug	drug	NOUN
bibechana-80853	38	22	discovery	discovery	NOUN
bibechana-80853	38	23	and	and	CCONJ
bibechana-80853	38	24	development	development	NOUN
bibechana-80853	38	25	,	,	PUNCT
bibechana-80853	38	26	the	the	DET
bibechana-80853	38	27	use	use	NOUN
bibechana-80853	38	28	of	of	ADP
bibechana-80853	38	29	in	in	ADP
bibechana-80853	38	30	silico	silico	NOUN
bibechana-80853	38	31	approaches	approach	NOUN
bibechana-80853	38	32	is	be	AUX
bibechana-80853	38	33	on	on	ADP
bibechana-80853	38	34	the	the	DET
bibechana-80853	38	35	rise	rise	NOUN
bibechana-80853	38	36	[	[	X
bibechana-80853	38	37	18–20	18–20	NUM
bibechana-80853	38	38	]	]	PUNCT
bibechana-80853	38	39	.	.	PUNCT
bibechana-80853	39	1	this	this	DET
bibechana-80853	39	2	technique	technique	NOUN
bibechana-80853	39	3	employs	employ	VERB
bibechana-80853	39	4	a	a	DET
bibechana-80853	39	5	docking	docking	NOUN
bibechana-80853	39	6	server	server	NOUN
bibechana-80853	39	7	to	to	PART
bibechana-80853	39	8	identify	identify	VERB
bibechana-80853	39	9	novel	novel	ADJ
bibechana-80853	39	10	ligands	ligand	NOUN
bibechana-80853	39	11	for	for	ADP
bibechana-80853	39	12	receptors	receptor	NOUN
bibechana-80853	39	13	with	with	ADP
bibechana-80853	39	14	known	know	VERB
bibechana-80853	39	15	structures	structure	NOUN
bibechana-80853	39	16	,	,	PUNCT
bibechana-80853	39	17	facilitating	facilitate	VERB
bibechana-80853	39	18	the	the	DET
bibechana-80853	39	19	screening	screening	NOUN
bibechana-80853	39	20	of	of	ADP
bibechana-80853	39	21	multi	multi	ADJ
bibechana-80853	39	22	-	-	ADJ
bibechana-80853	39	23	compound	compound	ADJ
bibechana-80853	39	24	databases	database	NOUN
bibechana-80853	39	25	for	for	ADP
bibechana-80853	39	26	molecules	molecule	NOUN
bibechana-80853	39	27	that	that	PRON
bibechana-80853	39	28	fit	fit	VERB
bibechana-80853	39	29	a	a	DET
bibechana-80853	39	30	receptor	receptor	NOUN
bibechana-80853	39	31	's	's	PART
bibechana-80853	39	32	binding	bind	VERB
bibechana-80853	39	33	site	site	NOUN
bibechana-80853	39	34	,	,	PUNCT
bibechana-80853	39	35	thus	thus	ADV
bibechana-80853	39	36	eliminating	eliminate	VERB
bibechana-80853	39	37	the	the	DET
bibechana-80853	39	38	initial	initial	ADJ
bibechana-80853	39	39	need	need	NOUN
bibechana-80853	39	40	for	for	ADP
bibechana-80853	39	41	wet	wet	ADJ
bibechana-80853	39	42	lab	lab	NOUN
bibechana-80853	39	43	experiments	experiment	NOUN
bibechana-80853	39	44	[	[	X
bibechana-80853	39	45	21–23	21–23	X
bibechana-80853	39	46	]	]	X
bibechana-80853	39	47	.	.	PUNCT
bibechana-80853	40	1	this	this	DET
bibechana-80853	40	2	study	study	NOUN
bibechana-80853	40	3	involves	involve	VERB
bibechana-80853	40	4	an	an	DET
bibechana-80853	40	5	in	in	ADP
bibechana-80853	40	6	silico	silico	NOUN
bibechana-80853	40	7	screening	screening	NOUN
bibechana-80853	40	8	of	of	ADP
bibechana-80853	40	9	compounds	compound	NOUN
bibechana-80853	40	10	from	from	ADP
bibechana-80853	40	11	k.	k.	PROPN
bibechana-80853	40	12	pinnata	pinnata	PROPN
bibechana-80853	40	13	to	to	PART
bibechana-80853	40	14	assess	assess	VERB
bibechana-80853	40	15	their	their	PRON
bibechana-80853	40	16	potential	potential	NOUN
bibechana-80853	40	17	to	to	PART
bibechana-80853	40	18	modulate	modulate	VERB
bibechana-80853	40	19	the	the	DET
bibechana-80853	40	20	mr	mr	PROPN
bibechana-80853	40	21	protein	protein	NOUN
bibechana-80853	40	22	and	and	CCONJ
bibechana-80853	40	23	for	for	ADP
bibechana-80853	40	24	molecularlevel	molecularlevel	NOUN
bibechana-80853	40	25	understanding	understanding	NOUN
bibechana-80853	40	26	of	of	ADP
bibechana-80853	40	27	the	the	DET
bibechana-80853	40	28	relevant	relevant	ADJ
bibechana-80853	40	29	pathways	pathway	NOUN
bibechana-80853	40	30	associated	associate	VERB
bibechana-80853	40	31	with	with	ADP
bibechana-80853	40	32	the	the	DET
bibechana-80853	40	33	modulation	modulation	NOUN
bibechana-80853	40	34	.	.	PUNCT
bibechana-80853	41	1	2	2	NUM
bibechana-80853	41	2	methodology	methodology	NOUN
bibechana-80853	41	3	2.1	2.1	NUM
bibechana-80853	41	4	ligand	ligand	NOUN
bibechana-80853	41	5	search	search	NOUN
bibechana-80853	41	6	twenty	twenty	NUM
bibechana-80853	41	7	phytochemicals	phytochemical	NOUN
bibechana-80853	41	8	of	of	ADP
bibechana-80853	41	9	k.	k.	PROPN
bibechana-80853	41	10	pinnata	pinnata	PROPN
bibechana-80853	41	11	were	be	AUX
bibechana-80853	41	12	identified	identify	VERB
bibechana-80853	41	13	from	from	ADP
bibechana-80853	41	14	the	the	DET
bibechana-80853	41	15	literature	literature	NOUN
bibechana-80853	41	16	(	(	PUNCT
bibechana-80853	41	17	google	google	PROPN
bibechana-80853	41	18	scholar	scholar	NOUN
bibechana-80853	41	19	,	,	PUNCT
bibechana-80853	41	20	researchgate	researchgate	NOUN
bibechana-80853	41	21	,	,	PUNCT
bibechana-80853	41	22	pubmed	pubmed	PROPN
bibechana-80853	41	23	,	,	PUNCT
bibechana-80853	41	24	sciencedirect	sciencedirect	PROPN
bibechana-80853	41	25	)	)	PUNCT
bibechana-80853	41	26	and	and	CCONJ
bibechana-80853	41	27	are	be	AUX
bibechana-80853	41	28	presented	present	VERB
bibechana-80853	41	29	in	in	ADP
bibechana-80853	41	30	table	table	NOUN
bibechana-80853	41	31	1	1	NUM
bibechana-80853	41	32	along	along	ADP
bibechana-80853	41	33	with	with	ADP
bibechana-80853	41	34	their	their	PRON
bibechana-80853	41	35	pubchem	pubchem	NOUN
bibechana-80853	41	36	cid	cid	NOUN
bibechana-80853	41	37	.	.	PUNCT
bibechana-80853	42	1	the	the	DET
bibechana-80853	42	2	compounds	compound	NOUN
bibechana-80853	42	3	'	'	PART
bibechana-80853	42	4	structured	structured	ADJ
bibechana-80853	42	5	data	data	NOUN
bibechana-80853	42	6	files	file	NOUN
bibechana-80853	42	7	(	(	PUNCT
bibechana-80853	42	8	sdf	sdf	NOUN
bibechana-80853	42	9	)	)	PUNCT
bibechana-80853	42	10	were	be	AUX
bibechana-80853	42	11	downloaded	download	VERB
bibechana-80853	42	12	from	from	ADP
bibechana-80853	42	13	the	the	DET
bibechana-80853	42	14	pubchem	pubchem	NOUN
bibechana-80853	42	15	database	database	NOUN
bibechana-80853	42	16	[	[	X
bibechana-80853	42	17	23	23	NUM
bibechana-80853	42	18	]	]	PUNCT
bibechana-80853	42	19	.	.	PUNCT
bibechana-80853	43	1	2.2	2.2	NUM
bibechana-80853	43	2	protein	protein	NOUN
bibechana-80853	43	3	target	target	NOUN
bibechana-80853	43	4	search	search	NOUN
bibechana-80853	43	5	probable	probable	ADJ
bibechana-80853	43	6	targets	target	NOUN
bibechana-80853	43	7	were	be	AUX
bibechana-80853	43	8	identified	identify	VERB
bibechana-80853	43	9	using	use	VERB
bibechana-80853	43	10	the	the	DET
bibechana-80853	43	11	superpred	superpre	VERB
bibechana-80853	43	12	web	web	NOUN
bibechana-80853	43	13	server	server	NOUN
bibechana-80853	43	14	(	(	PUNCT
bibechana-80853	43	15	https://prediction.charite	https://prediction.charite	PROPN
bibechana-80853	43	16	.	.	PUNCT
bibechana-80853	44	1	de/	de/	NOUN
bibechana-80853	44	2	)	)	PUNCT
bibechana-80853	45	1	[	[	X
bibechana-80853	45	2	24	24	NUM
bibechana-80853	45	3	]	]	PUNCT
bibechana-80853	45	4	.	.	PUNCT
bibechana-80853	46	1	it	it	PRON
bibechana-80853	46	2	is	be	AUX
bibechana-80853	46	3	used	use	VERB
bibechana-80853	46	4	for	for	ADP
bibechana-80853	46	5	predicting	predict	VERB
bibechana-80853	46	6	the	the	DET
bibechana-80853	46	7	potential	potential	ADJ
bibechana-80853	46	8	target	target	NOUN
bibechana-80853	46	9	proteins	protein	NOUN
bibechana-80853	46	10	for	for	ADP
bibechana-80853	46	11	a	a	DET
bibechana-80853	46	12	given	give	VERB
bibechana-80853	46	13	set	set	NOUN
bibechana-80853	46	14	of	of	ADP
bibechana-80853	46	15	ligands	ligand	NOUN
bibechana-80853	46	16	.	.	PUNCT
bibechana-80853	47	1	a	a	DET
bibechana-80853	47	2	percentage	percentage	NOUN
bibechana-80853	47	3	bar	bar	NOUN
bibechana-80853	47	4	indicates	indicate	VERB
bibechana-80853	47	5	the	the	DET
bibechana-80853	47	6	probability	probability	NOUN
bibechana-80853	47	7	of	of	ADP
bibechana-80853	47	8	the	the	DET
bibechana-80853	47	9	ligand	ligand	NOUN
bibechana-80853	47	10	binding	bind	VERB
bibechana-80853	47	11	to	to	ADP
bibechana-80853	47	12	the	the	DET
bibechana-80853	47	13	protein	protein	NOUN
bibechana-80853	47	14	.	.	PUNCT
bibechana-80853	48	1	this	this	DET
bibechana-80853	48	2	probability	probability	NOUN
bibechana-80853	48	3	is	be	AUX
bibechana-80853	48	4	based	base	VERB
bibechana-80853	48	5	on	on	ADP
bibechana-80853	48	6	structural	structural	ADJ
bibechana-80853	48	7	similarity	similarity	NOUN
bibechana-80853	48	8	,	,	PUNCT
bibechana-80853	48	9	binding	bind	VERB
bibechana-80853	48	10	affinity	affinity	NOUN
bibechana-80853	48	11	,	,	PUNCT
bibechana-80853	48	12	and	and	CCONJ
bibechana-80853	48	13	other	other	ADJ
bibechana-80853	48	14	computational	computational	ADJ
bibechana-80853	48	15	predictions	prediction	NOUN
bibechana-80853	48	16	.	.	PUNCT
bibechana-80853	49	1	the	the	DET
bibechana-80853	49	2	protein	protein	NOUN
bibechana-80853	49	3	target	target	NOUN
bibechana-80853	49	4	with	with	ADP
bibechana-80853	49	5	the	the	DET
bibechana-80853	49	6	highest	high	ADJ
bibechana-80853	49	7	probability	probability	NOUN
bibechana-80853	49	8	,	,	PUNCT
bibechana-80853	49	9	which	which	PRON
bibechana-80853	49	10	was	be	AUX
bibechana-80853	49	11	commonly	commonly	ADV
bibechana-80853	49	12	found	find	VERB
bibechana-80853	49	13	among	among	ADP
bibechana-80853	49	14	all	all	DET
bibechana-80853	49	15	the	the	DET
bibechana-80853	49	16	ligands	ligand	NOUN
bibechana-80853	49	17	,	,	PUNCT
bibechana-80853	49	18	was	be	AUX
bibechana-80853	49	19	chosen	choose	VERB
bibechana-80853	49	20	.	.	PUNCT
bibechana-80853	50	1	other	other	ADJ
bibechana-80853	50	2	factors	factor	NOUN
bibechana-80853	50	3	considered	consider	VERB
bibechana-80853	50	4	during	during	ADP
bibechana-80853	50	5	this	this	DET
bibechana-80853	50	6	process	process	NOUN
bibechana-80853	50	7	included	include	VERB
bibechana-80853	50	8	ensuring	ensure	VERB
bibechana-80853	50	9	the	the	DET
bibechana-80853	50	10	protein	protein	NOUN
bibechana-80853	50	11	resolution	resolution	NOUN
bibechana-80853	50	12	was	be	AUX
bibechana-80853	50	13	below	below	ADP
bibechana-80853	50	14	2	2	NUM
bibechana-80853	50	15	å	å	NOUN
bibechana-80853	50	16	,	,	PUNCT
bibechana-80853	50	17	no	no	DET
bibechana-80853	50	18	mutations	mutation	NOUN
bibechana-80853	50	19	were	be	AUX
bibechana-80853	50	20	present	present	ADJ
bibechana-80853	50	21	,	,	PUNCT
bibechana-80853	50	22	and	and	CCONJ
bibechana-80853	50	23	a	a	DET
bibechana-80853	50	24	native	native	ADJ
bibechana-80853	50	25	ligand	ligand	NOUN
bibechana-80853	50	26	was	be	AUX
bibechana-80853	50	27	present	present	ADJ
bibechana-80853	50	28	.	.	PUNCT
bibechana-80853	51	1	eventually	eventually	ADV
bibechana-80853	51	2	,	,	PUNCT
bibechana-80853	51	3	a	a	DET
bibechana-80853	51	4	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	51	5	receptor	receptor	NOUN
bibechana-80853	51	6	target	target	NOUN
bibechana-80853	51	7	(	(	PUNCT
bibechana-80853	51	8	pdb	pdb	PROPN
bibechana-80853	51	9	i	i	PROPN
bibechana-80853	51	10	d	d	PROPN
bibechana-80853	51	11	:	:	PUNCT
bibechana-80853	51	12	5l7e	5l7e	NOUN
bibechana-80853	51	13	)	)	PUNCT
bibechana-80853	51	14	with	with	ADP
bibechana-80853	51	15	a	a	DET
bibechana-80853	51	16	resolution	resolution	NOUN
bibechana-80853	51	17	of	of	ADP
bibechana-80853	51	18	1.86	1.86	NUM
bibechana-80853	51	19	å	å	NOUN
bibechana-80853	51	20	was	be	AUX
bibechana-80853	51	21	chosen	choose	VERB
bibechana-80853	51	22	with	with	ADP
bibechana-80853	51	23	a	a	DET
bibechana-80853	51	24	native	native	ADJ
bibechana-80853	51	25	ligand	ligand	NOUN
bibechana-80853	51	26	(	(	PUNCT
bibechana-80853	51	27	6q0	6q0	NUM
bibechana-80853	51	28	)	)	PUNCT
bibechana-80853	51	29	.	.	PUNCT
bibechana-80853	52	1	the	the	DET
bibechana-80853	52	2	structural	structural	ADJ
bibechana-80853	52	3	data	datum	NOUN
bibechana-80853	52	4	of	of	ADP
bibechana-80853	52	5	the	the	DET
bibechana-80853	52	6	protein	protein	NOUN
bibechana-80853	52	7	was	be	AUX
bibechana-80853	52	8	retrieved	retrieve	VERB
bibechana-80853	52	9	from	from	ADP
bibechana-80853	52	10	the	the	DET
bibechana-80853	52	11	rcsb	rcsb	ADJ
bibechana-80853	52	12	protein	protein	NOUN
bibechana-80853	52	13	bank	bank	NOUN
bibechana-80853	52	14	(	(	PUNCT
bibechana-80853	52	15	https://www.rcsb.org/	https://www.rcsb.org/	ADV
bibechana-80853	52	16	)	)	PUNCT
bibechana-80853	52	17	in	in	ADP
bibechana-80853	52	18	pdb	pdb	PROPN
bibechana-80853	52	19	format	format	NOUN
bibechana-80853	52	20	..	..	PUNCT
bibechana-80853	52	21	2.3	2.3	NUM
bibechana-80853	52	22	ligand	ligand	NOUN
bibechana-80853	52	23	optimization	optimization	NOUN
bibechana-80853	52	24	the	the	DET
bibechana-80853	52	25	native	native	ADJ
bibechana-80853	52	26	ligand	ligand	NOUN
bibechana-80853	52	27	(	(	PUNCT
bibechana-80853	52	28	6q0	6q0	NUM
bibechana-80853	52	29	)	)	PUNCT
bibechana-80853	52	30	was	be	AUX
bibechana-80853	52	31	optimized	optimize	VERB
bibechana-80853	52	32	before	before	ADP
bibechana-80853	52	33	molecular	molecular	ADJ
bibechana-80853	52	34	docking	docking	NOUN
bibechana-80853	52	35	by	by	ADP
bibechana-80853	52	36	the	the	DET
bibechana-80853	52	37	use	use	NOUN
bibechana-80853	52	38	of	of	ADP
bibechana-80853	52	39	the	the	DET
bibechana-80853	52	40	avogadro	avogadro	PROPN
bibechana-80853	52	41	program	program	NOUN
bibechana-80853	52	42	[	[	X
bibechana-80853	52	43	25	25	NUM
bibechana-80853	52	44	]	]	PUNCT
bibechana-80853	52	45	.	.	PUNCT
bibechana-80853	53	1	it	it	PRON
bibechana-80853	53	2	is	be	AUX
bibechana-80853	53	3	an	an	DET
bibechana-80853	53	4	advanced	advanced	ADJ
bibechana-80853	53	5	software	software	NOUN
bibechana-80853	53	6	for	for	ADP
bibechana-80853	53	7	editing	edit	VERB
bibechana-80853	53	8	and	and	CCONJ
bibechana-80853	53	9	visualizing	visualize	VERB
bibechana-80853	53	10	molecules	molecule	NOUN
bibechana-80853	53	11	,	,	PUNCT
bibechana-80853	53	12	used	use	VERB
bibechana-80853	53	13	in	in	ADP
bibechana-80853	53	14	computational	computational	ADJ
bibechana-80853	53	15	chemistry	chemistry	NOUN
bibechana-80853	53	16	,	,	PUNCT
bibechana-80853	53	17	molecular	molecular	ADJ
bibechana-80853	53	18	modeling	modeling	NOUN
bibechana-80853	53	19	,	,	PUNCT
bibechana-80853	53	20	and	and	CCONJ
bibechana-80853	53	21	bioinformatics	bioinformatics	NOUN
bibechana-80853	53	22	for	for	ADP
bibechana-80853	53	23	optimizing	optimize	VERB
bibechana-80853	53	24	molecular	molecular	ADJ
bibechana-80853	53	25	geometries	geometry	NOUN
bibechana-80853	53	26	[	[	X
bibechana-80853	53	27	26	26	NUM
bibechana-80853	53	28	]	]	PUNCT
bibechana-80853	53	29	.	.	PUNCT
bibechana-80853	54	1	the	the	DET
bibechana-80853	54	2	universal	universal	ADJ
bibechana-80853	54	3	force	force	NOUN
bibechana-80853	54	4	field	field	NOUN
bibechana-80853	54	5	(	(	PUNCT
bibechana-80853	54	6	uff	uff	PROPN
bibechana-80853	54	7	)	)	PUNCT
bibechana-80853	54	8	was	be	AUX
bibechana-80853	54	9	utilized	utilize	VERB
bibechana-80853	54	10	to	to	PART
bibechana-80853	54	11	optimize	optimize	VERB
bibechana-80853	54	12	the	the	DET
bibechana-80853	54	13	molecular	molecular	ADJ
bibechana-80853	54	14	geometries	geometry	NOUN
bibechana-80853	54	15	of	of	ADP
bibechana-80853	54	16	the	the	DET
bibechana-80853	54	17	compounds	compound	NOUN
bibechana-80853	54	18	,	,	PUNCT
bibechana-80853	54	19	the	the	DET
bibechana-80853	54	20	conjugate	conjugate	ADJ
bibechana-80853	54	21	gradient	gradient	NOUN
bibechana-80853	54	22	method	method	NOUN
bibechana-80853	54	23	was	be	AUX
bibechana-80853	54	24	employed	employ	VERB
bibechana-80853	54	25	,	,	PUNCT
bibechana-80853	54	26	and	and	CCONJ
bibechana-80853	54	27	energy	energy	NOUN
bibechana-80853	54	28	convergence	convergence	NOUN
bibechana-80853	54	29	was	be	AUX
bibechana-80853	54	30	adjusted	adjust	VERB
bibechana-80853	54	31	to	to	ADP
bibechana-80853	54	32	10	10	NUM
bibechana-80853	54	33	-	-	SYM
bibechana-80853	54	34	8	8	NUM
bibechana-80853	54	35	units	unit	NOUN
bibechana-80853	54	36	to	to	PART
bibechana-80853	54	37	reduce	reduce	VERB
bibechana-80853	54	38	their	their	PRON
bibechana-80853	54	39	structural	structural	ADJ
bibechana-80853	54	40	complexities	complexity	NOUN
bibechana-80853	54	41	[	[	X
bibechana-80853	54	42	27,28	27,28	NUM
bibechana-80853	54	43	]	]	X
bibechana-80853	54	44	.	.	PUNCT
bibechana-80853	55	1	alongside	alongside	ADP
bibechana-80853	55	2	the	the	DET
bibechana-80853	55	3	native	native	ADJ
bibechana-80853	55	4	ligand	ligand	NOUN
bibechana-80853	55	5	,	,	PUNCT
bibechana-80853	55	6	the	the	DET
bibechana-80853	55	7	same	same	ADJ
bibechana-80853	55	8	optimization	optimization	NOUN
bibechana-80853	55	9	process	process	NOUN
bibechana-80853	55	10	was	be	AUX
bibechana-80853	55	11	applied	apply	VERB
bibechana-80853	55	12	to	to	ADP
bibechana-80853	55	13	all	all	DET
bibechana-80853	55	14	the	the	DET
bibechana-80853	55	15	20	20	NUM
bibechana-80853	55	16	compounds	compound	NOUN
bibechana-80853	55	17	.	.	PUNCT
bibechana-80853	56	1	after	after	ADP
bibechana-80853	56	2	the	the	DET
bibechana-80853	56	3	optimization	optimization	NOUN
bibechana-80853	56	4	,	,	PUNCT
bibechana-80853	56	5	it	it	PRON
bibechana-80853	56	6	was	be	AUX
bibechana-80853	56	7	saved	save	VERB
bibechana-80853	56	8	in	in	ADP
bibechana-80853	56	9	pdb	pdb	PROPN
bibechana-80853	56	10	format	format	NOUN
bibechana-80853	56	11	for	for	ADP
bibechana-80853	56	12	molecular	molecular	ADJ
bibechana-80853	56	13	docking	docking	NOUN
bibechana-80853	56	14	calculations	calculation	NOUN
bibechana-80853	56	15	.	.	PUNCT
bibechana-80853	57	1	https://prediction.charite.de/	https://prediction.charite.de/	PROPN
bibechana-80853	57	2	https://prediction.charite.de/	https://prediction.charite.de/	PROPN
bibechana-80853	57	3	ram	ram	PROPN
bibechana-80853	57	4	lal	lal	PROPN
bibechana-80853	57	5	(	(	PUNCT
bibechana-80853	57	6	swagat	swagat	ADJ
bibechana-80853	57	7	)	)	PUNCT
bibechana-80853	57	8	shrestha	shrestha	NOUN
bibechana-80853	57	9	et	et	PROPN
bibechana-80853	58	1	al./	al./	ADV
bibechana-80853	58	2	bibechana	bibechana	PROPN
bibechana-80853	58	3	22	22	NUM
bibechana-80853	58	4	(	(	PUNCT
bibechana-80853	58	5	2025	2025	NUM
bibechana-80853	58	6	)	)	PUNCT
bibechana-80853	58	7	291	291	NUM
bibechana-80853	58	8	-	-	SYM
bibechana-80853	58	9	298	298	NUM
bibechana-80853	58	10	293	293	NUM
bibechana-80853	58	11	2.4	2.4	NUM
bibechana-80853	58	12	protein	protein	NOUN
bibechana-80853	58	13	structure	structure	NOUN
bibechana-80853	58	14	optimization	optimization	NOUN
bibechana-80853	58	15	the	the	DET
bibechana-80853	58	16	pdb	pdb	PROPN
bibechana-80853	58	17	structure	structure	NOUN
bibechana-80853	58	18	with	with	ADP
bibechana-80853	58	19	pdb	pdb	PROPN
bibechana-80853	59	1	i	i	PROPN
bibechana-80853	59	2	d	d	PROPN
bibechana-80853	59	3	of	of	ADP
bibechana-80853	59	4	5l7e	5l7e	NOUN
bibechana-80853	59	5	was	be	AUX
bibechana-80853	59	6	opened	open	VERB
bibechana-80853	59	7	in	in	ADP
bibechana-80853	59	8	the	the	DET
bibechana-80853	59	9	pymol	pymol	NOUN
bibechana-80853	59	10	program	program	NOUN
bibechana-80853	59	11	.	.	PUNCT
bibechana-80853	60	1	when	when	SCONJ
bibechana-80853	60	2	the	the	DET
bibechana-80853	60	3	water	water	NOUN
bibechana-80853	60	4	molecules	molecule	NOUN
bibechana-80853	60	5	are	be	AUX
bibechana-80853	60	6	removed	remove	VERB
bibechana-80853	60	7	from	from	ADP
bibechana-80853	60	8	a	a	DET
bibechana-80853	60	9	protein	protein	NOUN
bibechana-80853	60	10	,	,	PUNCT
bibechana-80853	60	11	it	it	PRON
bibechana-80853	60	12	is	be	AUX
bibechana-80853	60	13	known	know	VERB
bibechana-80853	60	14	as	as	ADP
bibechana-80853	60	15	the	the	DET
bibechana-80853	60	16	holoprotein	holoprotein	NOUN
bibechana-80853	60	17	.	.	PUNCT
bibechana-80853	61	1	after	after	SCONJ
bibechana-80853	61	2	the	the	DET
bibechana-80853	61	3	native	native	ADJ
bibechana-80853	61	4	ligand	ligand	NOUN
bibechana-80853	61	5	is	be	AUX
bibechana-80853	61	6	extracted	extract	VERB
bibechana-80853	61	7	,	,	PUNCT
bibechana-80853	61	8	the	the	DET
bibechana-80853	61	9	resulting	result	VERB
bibechana-80853	61	10	structure	structure	NOUN
bibechana-80853	61	11	is	be	AUX
bibechana-80853	61	12	called	call	VERB
bibechana-80853	61	13	the	the	DET
bibechana-80853	61	14	apoprotein	apoprotein	NOUN
bibechana-80853	61	15	.	.	PUNCT
bibechana-80853	62	1	the	the	DET
bibechana-80853	62	2	extra	extra	ADJ
bibechana-80853	62	3	chain	chain	NOUN
bibechana-80853	62	4	present	present	NOUN
bibechana-80853	62	5	in	in	ADP
bibechana-80853	62	6	the	the	DET
bibechana-80853	62	7	target	target	NOUN
bibechana-80853	62	8	was	be	AUX
bibechana-80853	62	9	removed	remove	VERB
bibechana-80853	62	10	,	,	PUNCT
bibechana-80853	62	11	polar	polar	ADJ
bibechana-80853	62	12	hydrogens	hydrogen	NOUN
bibechana-80853	62	13	were	be	AUX
bibechana-80853	62	14	added	add	VERB
bibechana-80853	62	15	,	,	PUNCT
bibechana-80853	62	16	and	and	CCONJ
bibechana-80853	62	17	it	it	PRON
bibechana-80853	62	18	was	be	AUX
bibechana-80853	62	19	subsequently	subsequently	ADV
bibechana-80853	62	20	saved	save	VERB
bibechana-80853	62	21	in	in	ADP
bibechana-80853	62	22	pdb	pdb	PROPN
bibechana-80853	62	23	format	format	NOUN
bibechana-80853	62	24	.	.	PUNCT
bibechana-80853	63	1	2.5	2.5	NUM
bibechana-80853	63	2	molecular	molecular	ADJ
bibechana-80853	63	3	docking	docking	NOUN
bibechana-80853	63	4	calculations	calculation	NOUN
bibechana-80853	63	5	ligand	ligand	NOUN
bibechana-80853	63	6	-	-	PUNCT
bibechana-80853	63	7	protein	protein	NOUN
bibechana-80853	63	8	docking	docking	NOUN
bibechana-80853	63	9	is	be	AUX
bibechana-80853	63	10	an	an	DET
bibechana-80853	63	11	optimization	optimization	NOUN
bibechana-80853	63	12	problem	problem	NOUN
bibechana-80853	63	13	focused	focus	VERB
bibechana-80853	63	14	on	on	ADP
bibechana-80853	63	15	predicting	predict	VERB
bibechana-80853	63	16	the	the	DET
bibechana-80853	63	17	position	position	NOUN
bibechana-80853	63	18	and	and	CCONJ
bibechana-80853	63	19	pose	pose	VERB
bibechana-80853	63	20	of	of	ADP
bibechana-80853	63	21	a	a	DET
bibechana-80853	63	22	ligand	ligand	NOUN
bibechana-80853	63	23	that	that	PRON
bibechana-80853	63	24	achieves	achieve	VERB
bibechana-80853	63	25	the	the	DET
bibechana-80853	63	26	lowest	low	ADJ
bibechana-80853	63	27	binding	bind	VERB
bibechana-80853	63	28	energy	energy	NOUN
bibechana-80853	63	29	within	within	ADP
bibechana-80853	63	30	the	the	DET
bibechana-80853	63	31	receptor	receptor	NOUN
bibechana-80853	63	32	's	's	PART
bibechana-80853	63	33	active	active	ADJ
bibechana-80853	63	34	site	site	NOUN
bibechana-80853	63	35	.	.	PUNCT
bibechana-80853	64	1	docking	dock	VERB
bibechana-80853	64	2	aids	aid	NOUN
bibechana-80853	64	3	in	in	ADP
bibechana-80853	64	4	predicting	predict	VERB
bibechana-80853	64	5	the	the	DET
bibechana-80853	64	6	favorable	favorable	ADJ
bibechana-80853	64	7	binding	bind	VERB
bibechana-80853	64	8	geometries	geometry	NOUN
bibechana-80853	64	9	of	of	ADP
bibechana-80853	64	10	a	a	DET
bibechana-80853	64	11	small	small	ADJ
bibechana-80853	64	12	molecule	molecule	NOUN
bibechana-80853	64	13	within	within	ADP
bibechana-80853	64	14	a	a	DET
bibechana-80853	64	15	target	target	NOUN
bibechana-80853	64	16	protein	protein	NOUN
bibechana-80853	64	17	's	's	PART
bibechana-80853	64	18	binding	bind	VERB
bibechana-80853	64	19	site	site	NOUN
bibechana-80853	64	20	and	and	CCONJ
bibechana-80853	64	21	estimating	estimate	VERB
bibechana-80853	64	22	the	the	DET
bibechana-80853	64	23	docking	docking	NOUN
bibechana-80853	64	24	score	score	NOUN
bibechana-80853	64	25	of	of	ADP
bibechana-80853	64	26	the	the	DET
bibechana-80853	64	27	resulting	result	VERB
bibechana-80853	64	28	complex	complex	NOUN
bibechana-80853	64	29	[	[	X
bibechana-80853	64	30	29	29	NUM
bibechana-80853	64	31	]	]	PUNCT
bibechana-80853	64	32	.	.	PUNCT
bibechana-80853	65	1	for	for	ADP
bibechana-80853	65	2	the	the	DET
bibechana-80853	65	3	docking	docking	NOUN
bibechana-80853	65	4	purpose	purpose	NOUN
bibechana-80853	65	5	,	,	PUNCT
bibechana-80853	65	6	a	a	DET
bibechana-80853	65	7	web	web	NOUN
bibechana-80853	65	8	-	-	PUNCT
bibechana-80853	65	9	based	base	VERB
bibechana-80853	65	10	tool	tool	NOUN
bibechana-80853	65	11	known	know	VERB
bibechana-80853	65	12	as	as	ADP
bibechana-80853	65	13	the	the	DET
bibechana-80853	65	14	dockthor	dockthor	NOUN
bibechana-80853	65	15	(	(	PUNCT
bibechana-80853	65	16	rigid	rigid	ADJ
bibechana-80853	65	17	receptor	receptor	NOUN
bibechana-80853	65	18	approach	approach	NOUN
bibechana-80853	65	19	)	)	PUNCT
bibechana-80853	65	20	(	(	PUNCT
bibechana-80853	65	21	https://www.dockthor.lncc.br/	https://www.dockthor.lncc.br/	NOUN
bibechana-80853	65	22	)	)	PUNCT
bibechana-80853	65	23	[	[	X
bibechana-80853	65	24	30	30	NUM
bibechana-80853	65	25	]	]	PUNCT
bibechana-80853	65	26	was	be	AUX
bibechana-80853	65	27	used	use	VERB
bibechana-80853	65	28	.	.	PUNCT
bibechana-80853	66	1	for	for	ADP
bibechana-80853	66	2	this	this	PRON
bibechana-80853	66	3	,	,	PUNCT
bibechana-80853	66	4	the	the	DET
bibechana-80853	66	5	apo	apo	PROPN
bibechana-80853	66	6	form	form	NOUN
bibechana-80853	66	7	of	of	ADP
bibechana-80853	66	8	the	the	DET
bibechana-80853	66	9	protein	protein	NOUN
bibechana-80853	66	10	,	,	PUNCT
bibechana-80853	66	11	native	native	ADJ
bibechana-80853	66	12	ligand	ligand	NOUN
bibechana-80853	66	13	,	,	PUNCT
bibechana-80853	66	14	and	and	CCONJ
bibechana-80853	66	15	the	the	DET
bibechana-80853	66	16	test	test	NOUN
bibechana-80853	66	17	compounds	compound	NOUN
bibechana-80853	66	18	were	be	AUX
bibechana-80853	66	19	utilized	utilize	VERB
bibechana-80853	66	20	in	in	ADP
bibechana-80853	66	21	pdb	pdb	PROPN
bibechana-80853	66	22	form	form	NOUN
bibechana-80853	66	23	.	.	PUNCT
bibechana-80853	67	1	initially	initially	ADV
bibechana-80853	67	2	,	,	PUNCT
bibechana-80853	67	3	to	to	PART
bibechana-80853	67	4	validate	validate	VERB
bibechana-80853	67	5	the	the	DET
bibechana-80853	67	6	molecular	molecular	ADJ
bibechana-80853	67	7	docking	docking	NOUN
bibechana-80853	67	8	protocol	protocol	NOUN
bibechana-80853	67	9	,	,	PUNCT
bibechana-80853	67	10	the	the	DET
bibechana-80853	67	11	approach	approach	NOUN
bibechana-80853	67	12	used	use	VERB
bibechana-80853	67	13	by	by	ADP
bibechana-80853	67	14	adhikari	adhikari	PROPN
bibechana-80853	67	15	subin	subin	PROPN
bibechana-80853	67	16	and	and	CCONJ
bibechana-80853	67	17	shrestha	shrestha	PROPN
bibechana-80853	67	18	(	(	PUNCT
bibechana-80853	67	19	2024	2024	NUM
bibechana-80853	67	20	)	)	PUNCT
bibechana-80853	67	21	was	be	AUX
bibechana-80853	67	22	followed	follow	VERB
bibechana-80853	67	23	.	.	PUNCT
bibechana-80853	68	1	the	the	DET
bibechana-80853	68	2	apoprotein	apoprotein	NOUN
bibechana-80853	68	3	and	and	CCONJ
bibechana-80853	68	4	native	native	ADJ
bibechana-80853	68	5	ligand	ligand	NOUN
bibechana-80853	68	6	were	be	AUX
bibechana-80853	68	7	uploaded	upload	VERB
bibechana-80853	68	8	to	to	ADP
bibechana-80853	68	9	the	the	DET
bibechana-80853	68	10	server	server	NOUN
bibechana-80853	68	11	,	,	PUNCT
bibechana-80853	68	12	and	and	CCONJ
bibechana-80853	68	13	the	the	DET
bibechana-80853	68	14	following	follow	VERB
bibechana-80853	68	15	parameters	parameter	NOUN
bibechana-80853	68	16	were	be	AUX
bibechana-80853	68	17	applied	apply	VERB
bibechana-80853	68	18	:	:	PUNCT
bibechana-80853	68	19	grid	grid	NOUN
bibechana-80853	68	20	center	center	NOUN
bibechana-80853	68	21	(	(	PUNCT
bibechana-80853	68	22	x	x	NOUN
bibechana-80853	68	23	:	:	PUNCT
bibechana-80853	68	24	9	9	NUM
bibechana-80853	68	25	,	,	PUNCT
bibechana-80853	68	26	y	y	NOUN
bibechana-80853	68	27	:	:	PUNCT
bibechana-80853	68	28	14	14	NUM
bibechana-80853	68	29	,	,	PUNCT
bibechana-80853	68	30	z	z	NOUN
bibechana-80853	68	31	:	:	PUNCT
bibechana-80853	68	32	11	11	NUM
bibechana-80853	68	33	)	)	PUNCT
bibechana-80853	68	34	,	,	PUNCT
bibechana-80853	68	35	grid	grid	NOUN
bibechana-80853	68	36	size	size	NOUN
bibechana-80853	68	37	(	(	PUNCT
bibechana-80853	68	38	x	x	NOUN
bibechana-80853	68	39	:	:	PUNCT
bibechana-80853	68	40	16	16	NUM
bibechana-80853	68	41	,	,	PUNCT
bibechana-80853	68	42	y	y	PROPN
bibechana-80853	68	43	:	:	PUNCT
bibechana-80853	68	44	16	16	NUM
bibechana-80853	68	45	,	,	PUNCT
bibechana-80853	68	46	z	z	NOUN
bibechana-80853	68	47	:	:	PUNCT
bibechana-80853	68	48	16	16	NUM
bibechana-80853	68	49	)	)	PUNCT
bibechana-80853	68	50	,	,	PUNCT
bibechana-80853	68	51	discretization	discretization	NOUN
bibechana-80853	68	52	:	:	PUNCT
bibechana-80853	68	53	0.17	0.17	NUM
bibechana-80853	68	54	,	,	PUNCT
bibechana-80853	68	55	number	number	NOUN
bibechana-80853	68	56	of	of	ADP
bibechana-80853	68	57	evaluations	evaluation	NOUN
bibechana-80853	68	58	:	:	PUNCT
bibechana-80853	68	59	1,000,000	1,000,000	NUM
bibechana-80853	68	60	,	,	PUNCT
bibechana-80853	68	61	population	population	NOUN
bibechana-80853	68	62	size	size	NOUN
bibechana-80853	68	63	:	:	PUNCT
bibechana-80853	68	64	750	750	NUM
bibechana-80853	68	65	,	,	PUNCT
bibechana-80853	68	66	and	and	CCONJ
bibechana-80853	68	67	number	number	NOUN
bibechana-80853	68	68	of	of	ADP
bibechana-80853	68	69	runs	run	NOUN
bibechana-80853	68	70	:	:	PUNCT
bibechana-80853	68	71	24	24	NUM
bibechana-80853	69	1	[	[	X
bibechana-80853	69	2	31	31	NUM
bibechana-80853	69	3	]	]	PUNCT
bibechana-80853	69	4	.	.	PUNCT
bibechana-80853	70	1	subsequently	subsequently	ADV
bibechana-80853	70	2	,	,	PUNCT
bibechana-80853	70	3	the	the	DET
bibechana-80853	70	4	test	test	NOUN
bibechana-80853	70	5	compounds	compound	NOUN
bibechana-80853	70	6	were	be	AUX
bibechana-80853	70	7	docked	dock	VERB
bibechana-80853	70	8	using	use	VERB
bibechana-80853	70	9	the	the	DET
bibechana-80853	70	10	same	same	ADJ
bibechana-80853	70	11	parameters	parameter	NOUN
bibechana-80853	70	12	as	as	ADP
bibechana-80853	70	13	those	those	PRON
bibechana-80853	70	14	for	for	ADP
bibechana-80853	70	15	the	the	DET
bibechana-80853	70	16	native	native	ADJ
bibechana-80853	70	17	ligand	ligand	NOUN
bibechana-80853	70	18	.	.	PUNCT
bibechana-80853	71	1	the	the	DET
bibechana-80853	71	2	docking	docking	NOUN
bibechana-80853	71	3	score	score	NOUN
bibechana-80853	71	4	measures	measure	VERB
bibechana-80853	71	5	the	the	DET
bibechana-80853	71	6	strength	strength	NOUN
bibechana-80853	71	7	of	of	ADP
bibechana-80853	71	8	the	the	DET
bibechana-80853	71	9	interaction	interaction	NOUN
bibechana-80853	71	10	between	between	ADP
bibechana-80853	71	11	the	the	DET
bibechana-80853	71	12	target	target	NOUN
bibechana-80853	71	13	and	and	CCONJ
bibechana-80853	71	14	the	the	DET
bibechana-80853	71	15	molecule	molecule	NOUN
bibechana-80853	71	16	.	.	PUNCT
bibechana-80853	72	1	it	it	PRON
bibechana-80853	72	2	reflects	reflect	VERB
bibechana-80853	72	3	the	the	DET
bibechana-80853	72	4	free	free	ADJ
bibechana-80853	72	5	energy	energy	NOUN
bibechana-80853	72	6	change	change	NOUN
bibechana-80853	72	7	upon	upon	SCONJ
bibechana-80853	72	8	binding	bind	VERB
bibechana-80853	72	9	on	on	ADP
bibechana-80853	72	10	a	a	DET
bibechana-80853	72	11	comparative	comparative	ADJ
bibechana-80853	72	12	basis	basis	NOUN
bibechana-80853	72	13	,	,	PUNCT
bibechana-80853	72	14	with	with	ADP
bibechana-80853	72	15	more	more	ADV
bibechana-80853	72	16	negative	negative	ADJ
bibechana-80853	72	17	values	value	NOUN
bibechana-80853	72	18	indicating	indicate	VERB
bibechana-80853	72	19	stronger	strong	ADJ
bibechana-80853	72	20	interactions	interaction	NOUN
bibechana-80853	72	21	[	[	X
bibechana-80853	72	22	30,32,33	30,32,33	NUM
bibechana-80853	72	23	]	]	PUNCT
bibechana-80853	72	24	.	.	PUNCT
bibechana-80853	73	1	2.6	2.6	NUM
bibechana-80853	73	2	protocol	protocol	NOUN
bibechana-80853	73	3	validation	validation	NOUN
bibechana-80853	73	4	via	via	ADP
bibechana-80853	73	5	rmsd	rmsd	NOUN
bibechana-80853	73	6	calculation	calculation	NOUN
bibechana-80853	73	7	root	root	NOUN
bibechana-80853	73	8	mean	mean	VERB
bibechana-80853	73	9	square	square	ADJ
bibechana-80853	73	10	deviation	deviation	NOUN
bibechana-80853	73	11	(	(	PUNCT
bibechana-80853	73	12	rmsd	rmsd	NOUN
bibechana-80853	73	13	)	)	PUNCT
bibechana-80853	73	14	measures	measure	NOUN
bibechana-80853	73	15	the	the	DET
bibechana-80853	73	16	average	average	ADJ
bibechana-80853	73	17	distance	distance	NOUN
bibechana-80853	73	18	between	between	ADP
bibechana-80853	73	19	atoms	atom	NOUN
bibechana-80853	73	20	in	in	ADP
bibechana-80853	73	21	a	a	DET
bibechana-80853	73	22	predicted	predict	VERB
bibechana-80853	73	23	model	model	NOUN
bibechana-80853	73	24	and	and	CCONJ
bibechana-80853	73	25	a	a	DET
bibechana-80853	73	26	reference	reference	NOUN
bibechana-80853	73	27	structure	structure	NOUN
bibechana-80853	73	28	,	,	PUNCT
bibechana-80853	73	29	assessing	assess	VERB
bibechana-80853	73	30	how	how	SCONJ
bibechana-80853	73	31	well	well	ADV
bibechana-80853	73	32	the	the	DET
bibechana-80853	73	33	predicted	predict	VERB
bibechana-80853	73	34	model	model	NOUN
bibechana-80853	73	35	aligns	align	VERB
bibechana-80853	73	36	with	with	ADP
bibechana-80853	73	37	the	the	DET
bibechana-80853	73	38	experimental	experimental	ADJ
bibechana-80853	73	39	or	or	CCONJ
bibechana-80853	73	40	reference	reference	NOUN
bibechana-80853	73	41	structure	structure	NOUN
bibechana-80853	73	42	.	.	PUNCT
bibechana-80853	74	1	lower	low	ADJ
bibechana-80853	74	2	rmsd	rmsd	PROPN
bibechana-80853	74	3	values	value	NOUN
bibechana-80853	74	4	indicate	indicate	VERB
bibechana-80853	74	5	a	a	DET
bibechana-80853	74	6	better	well	ADJ
bibechana-80853	74	7	fit	fit	NOUN
bibechana-80853	74	8	,	,	PUNCT
bibechana-80853	74	9	reflecting	reflect	VERB
bibechana-80853	74	10	a	a	DET
bibechana-80853	74	11	more	more	ADV
bibechana-80853	74	12	accurate	accurate	ADJ
bibechana-80853	74	13	prediction	prediction	NOUN
bibechana-80853	74	14	of	of	ADP
bibechana-80853	74	15	the	the	DET
bibechana-80853	74	16	ligand	ligand	NOUN
bibechana-80853	74	17	's	's	PART
bibechana-80853	74	18	binding	bind	VERB
bibechana-80853	74	19	mode	mode	NOUN
bibechana-80853	74	20	to	to	ADP
bibechana-80853	74	21	the	the	DET
bibechana-80853	74	22	target	target	NOUN
bibechana-80853	74	23	protein	protein	NOUN
bibechana-80853	74	24	[	[	X
bibechana-80853	74	25	34	34	NUM
bibechana-80853	74	26	]	]	PUNCT
bibechana-80853	74	27	.	.	PUNCT
bibechana-80853	75	1	an	an	DET
bibechana-80853	75	2	rmsd	rmsd	ADJ
bibechana-80853	75	3	value	value	NOUN
bibechana-80853	75	4	below	below	ADP
bibechana-80853	75	5	2.0	2.0	NUM
bibechana-80853	75	6	å	å	NOUN
bibechana-80853	75	7	[	[	X
bibechana-80853	75	8	35	35	NUM
bibechana-80853	75	9	]	]	PUNCT
bibechana-80853	75	10	is	be	AUX
bibechana-80853	75	11	widely	widely	ADV
bibechana-80853	75	12	accepted	accept	VERB
bibechana-80853	75	13	as	as	ADP
bibechana-80853	75	14	the	the	DET
bibechana-80853	75	15	benchmark	benchmark	NOUN
bibechana-80853	75	16	for	for	ADP
bibechana-80853	75	17	distinguishing	distinguish	VERB
bibechana-80853	75	18	between	between	ADP
bibechana-80853	75	19	successful	successful	ADJ
bibechana-80853	75	20	and	and	CCONJ
bibechana-80853	75	21	unsuccessful	unsuccessful	ADJ
bibechana-80853	75	22	reproductions	reproduction	NOUN
bibechana-80853	75	23	of	of	ADP
bibechana-80853	75	24	a	a	DET
bibechana-80853	75	25	known	know	VERB
bibechana-80853	75	26	binding	bind	VERB
bibechana-80853	75	27	mode	mode	NOUN
bibechana-80853	75	28	[	[	X
bibechana-80853	75	29	29,36	29,36	NUM
bibechana-80853	75	30	]	]	X
bibechana-80853	75	31	.	.	PUNCT
bibechana-80853	76	1	the	the	DET
bibechana-80853	76	2	heavy	heavy	ADJ
bibechana-80853	76	3	atom	atom	NOUN
bibechana-80853	76	4	rmsd	rmsd	NOUN
bibechana-80853	76	5	was	be	AUX
bibechana-80853	76	6	calculated	calculate	VERB
bibechana-80853	76	7	for	for	ADP
bibechana-80853	76	8	the	the	DET
bibechana-80853	76	9	native	native	ADJ
bibechana-80853	76	10	ligand	ligand	NOUN
bibechana-80853	76	11	with	with	ADP
bibechana-80853	76	12	the	the	DET
bibechana-80853	76	13	best	good	ADJ
bibechana-80853	76	14	binding	bind	VERB
bibechana-80853	76	15	affinity	affinity	NOUN
bibechana-80853	76	16	.	.	PUNCT
bibechana-80853	77	1	2.7	2.7	NUM
bibechana-80853	77	2	protein	protein	NOUN
bibechana-80853	77	3	-	-	PUNCT
bibechana-80853	77	4	ligand	ligand	NOUN
bibechana-80853	77	5	interactions	interaction	NOUN
bibechana-80853	77	6	plip	plip	PROPN
bibechana-80853	77	7	server	server	PROPN
bibechana-80853	77	8	(	(	PUNCT
bibechana-80853	77	9	https://plip-tool.biotec.tudresden.de/plip-web/plip/index	https://plip-tool.biotec.tudresden.de/plip-web/plip/index	PROPN
bibechana-80853	77	10	)	)	PUNCT
bibechana-80853	77	11	was	be	AUX
bibechana-80853	77	12	used	use	VERB
bibechana-80853	77	13	for	for	ADP
bibechana-80853	77	14	visualizing	visualize	VERB
bibechana-80853	77	15	three	three	NUM
bibechana-80853	77	16	-	-	PUNCT
bibechana-80853	77	17	dimensional	dimensional	ADJ
bibechana-80853	77	18	representations	representation	NOUN
bibechana-80853	77	19	of	of	ADP
bibechana-80853	77	20	protein	protein	NOUN
bibechana-80853	77	21	-	-	PUNCT
bibechana-80853	77	22	ligand	ligand	NOUN
bibechana-80853	77	23	interactions	interaction	NOUN
bibechana-80853	77	24	[	[	X
bibechana-80853	77	25	37	37	NUM
bibechana-80853	77	26	]	]	PUNCT
bibechana-80853	77	27	.	.	PUNCT
bibechana-80853	78	1	2.8	2.8	NUM
bibechana-80853	78	2	admet	admet	NOUN
bibechana-80853	78	3	properties	property	NOUN
bibechana-80853	78	4	and	and	CCONJ
bibechana-80853	78	5	toxicity	toxicity	NOUN
bibechana-80853	78	6	class	class	NOUN
bibechana-80853	78	7	identification	identification	NOUN
bibechana-80853	78	8	the	the	PRON
bibechana-80853	78	9	in	in	ADP
bibechana-80853	78	10	silico	silico	NOUN
bibechana-80853	78	11	properties	property	NOUN
bibechana-80853	78	12	for	for	ADP
bibechana-80853	78	13	absorption	absorption	NOUN
bibechana-80853	78	14	(	(	PUNCT
bibechana-80853	78	15	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	78	16	absorption	absorption	NOUN
bibechana-80853	78	17	and	and	CCONJ
bibechana-80853	78	18	p	p	ADJ
bibechana-80853	78	19	-	-	PUNCT
bibechana-80853	78	20	glycoprotein	glycoprotein	NOUN
bibechana-80853	78	21	substrate	substrate	NOUN
bibechana-80853	78	22	/	/	SYM
bibechana-80853	78	23	inhibitor	inhibitor	NOUN
bibechana-80853	78	24	status	status	NOUN
bibechana-80853	78	25	)	)	PUNCT
bibechana-80853	78	26	,	,	PUNCT
bibechana-80853	78	27	distribution	distribution	NOUN
bibechana-80853	78	28	(	(	PUNCT
bibechana-80853	78	29	blood	blood	NOUN
bibechana-80853	78	30	-	-	PUNCT
bibechana-80853	78	31	brain	brain	NOUN
bibechana-80853	78	32	barrier	barrier	NOUN
bibechana-80853	78	33	permeability	permeability	NOUN
bibechana-80853	78	34	)	)	PUNCT
bibechana-80853	78	35	,	,	PUNCT
bibechana-80853	78	36	metabolism	metabolism	NOUN
bibechana-80853	78	37	(	(	PUNCT
bibechana-80853	78	38	cytochrome	cytochrome	NOUN
bibechana-80853	78	39	p450	p450	NOUN
bibechana-80853	78	40	inhibition	inhibition	NOUN
bibechana-80853	78	41	or	or	CCONJ
bibechana-80853	78	42	substrate	substrate	NOUN
bibechana-80853	78	43	status	status	NOUN
bibechana-80853	78	44	)	)	PUNCT
bibechana-80853	78	45	,	,	PUNCT
bibechana-80853	78	46	and	and	CCONJ
bibechana-80853	78	47	excretion	excretion	NOUN
bibechana-80853	78	48	(	(	PUNCT
bibechana-80853	78	49	clearance	clearance	NOUN
bibechana-80853	78	50	)	)	PUNCT
bibechana-80853	78	51	were	be	AUX
bibechana-80853	78	52	evaluated	evaluate	VERB
bibechana-80853	78	53	using	use	VERB
bibechana-80853	78	54	the	the	DET
bibechana-80853	78	55	swissadme	swissadme	PROPN
bibechana-80853	78	56	server	server	PROPN
bibechana-80853	78	57	(	(	PUNCT
bibechana-80853	78	58	https://www.swissdock.ch/	https://www.swissdock.ch/	PROPN
bibechana-80853	78	59	)	)	PUNCT
bibechana-80853	78	60	.	.	PUNCT
bibechana-80853	79	1	the	the	DET
bibechana-80853	79	2	toxicity	toxicity	NOUN
bibechana-80853	79	3	class	class	NOUN
bibechana-80853	79	4	was	be	AUX
bibechana-80853	79	5	determined	determine	VERB
bibechana-80853	79	6	through	through	ADP
bibechana-80853	79	7	the	the	DET
bibechana-80853	79	8	protox	protox	NOUN
bibechana-80853	79	9	3.0	3.0	NUM
bibechana-80853	79	10	server	server	NOUN
bibechana-80853	79	11	(	(	PUNCT
bibechana-80853	79	12	https://tox.charite.de/protox3/	https://tox.charite.de/protox3/	PROPN
bibechana-80853	79	13	)	)	PUNCT
bibechana-80853	79	14	.	.	PUNCT
bibechana-80853	80	1	it	it	PRON
bibechana-80853	80	2	classifies	classify	VERB
bibechana-80853	80	3	compounds	compound	NOUN
bibechana-80853	80	4	into	into	ADP
bibechana-80853	80	5	six	six	NUM
bibechana-80853	80	6	toxicity	toxicity	NOUN
bibechana-80853	80	7	classes	class	NOUN
bibechana-80853	80	8	(	(	PUNCT
bibechana-80853	80	9	1	1	NUM
bibechana-80853	80	10	to	to	PART
bibechana-80853	80	11	6	6	NUM
bibechana-80853	80	12	)	)	PUNCT
bibechana-80853	80	13	based	base	VERB
bibechana-80853	80	14	on	on	ADP
bibechana-80853	80	15	their	their	PRON
bibechana-80853	80	16	predicted	predict	VERB
bibechana-80853	80	17	lethal	lethal	ADJ
bibechana-80853	80	18	dose	dose	NOUN
bibechana-80853	80	19	(	(	PUNCT
bibechana-80853	80	20	ld50	ld50	PROPN
bibechana-80853	80	21	)	)	PUNCT
bibechana-80853	80	22	and	and	CCONJ
bibechana-80853	80	23	potential	potential	ADJ
bibechana-80853	80	24	toxic	toxic	ADJ
bibechana-80853	80	25	effects	effect	NOUN
bibechana-80853	80	26	.	.	PUNCT
bibechana-80853	81	1	class	class	NOUN
bibechana-80853	81	2	1	1	NUM
bibechana-80853	81	3	represents	represent	VERB
bibechana-80853	81	4	the	the	DET
bibechana-80853	81	5	most	most	ADV
bibechana-80853	81	6	toxic	toxic	ADJ
bibechana-80853	81	7	compounds	compound	NOUN
bibechana-80853	81	8	,	,	PUNCT
bibechana-80853	81	9	while	while	SCONJ
bibechana-80853	81	10	class	class	NOUN
bibechana-80853	81	11	6	6	NUM
bibechana-80853	81	12	represents	represent	VERB
bibechana-80853	81	13	the	the	DET
bibechana-80853	81	14	least	least	ADJ
bibechana-80853	81	15	toxic	toxic	ADJ
bibechana-80853	81	16	.	.	PUNCT
bibechana-80853	82	1	3	3	NUM
bibechana-80853	82	2	results	result	NOUN
bibechana-80853	82	3	and	and	CCONJ
bibechana-80853	82	4	discussion	discussion	NOUN
bibechana-80853	82	5	3.1	3.1	NUM
bibechana-80853	82	6	molecular	molecular	ADJ
bibechana-80853	82	7	docking	docking	NOUN
bibechana-80853	82	8	protocol	protocol	NOUN
bibechana-80853	82	9	validation	validation	NOUN
bibechana-80853	82	10	by	by	ADP
bibechana-80853	82	11	superimposing	superimpose	VERB
bibechana-80853	82	12	the	the	DET
bibechana-80853	82	13	co	co	ADJ
bibechana-80853	82	14	-	-	ADJ
bibechana-80853	82	15	crystallized	crystallize	VERB
bibechana-80853	82	16	native	native	ADJ
bibechana-80853	82	17	ligand	ligand	NOUN
bibechana-80853	82	18	with	with	ADP
bibechana-80853	82	19	the	the	DET
bibechana-80853	82	20	docked	dock	VERB
bibechana-80853	82	21	ligand	ligand	NOUN
bibechana-80853	82	22	,	,	PUNCT
bibechana-80853	82	23	the	the	DET
bibechana-80853	82	24	heavy	heavy	ADJ
bibechana-80853	82	25	atom	atom	NOUN
bibechana-80853	82	26	rmsd	rmsd	NOUN
bibechana-80853	82	27	was	be	AUX
bibechana-80853	82	28	calculated	calculate	VERB
bibechana-80853	82	29	to	to	PART
bibechana-80853	82	30	be	be	AUX
bibechana-80853	82	31	1.79	1.79	NUM
bibechana-80853	82	32	å	å	NOUN
bibechana-80853	82	33	,	,	PUNCT
bibechana-80853	82	34	indicating	indicate	VERB
bibechana-80853	82	35	that	that	SCONJ
bibechana-80853	82	36	the	the	DET
bibechana-80853	82	37	docking	docking	NOUN
bibechana-80853	82	38	protocol	protocol	NOUN
bibechana-80853	82	39	was	be	AUX
bibechana-80853	82	40	reliable	reliable	ADJ
bibechana-80853	82	41	and	and	CCONJ
bibechana-80853	82	42	predicted	predict	VERB
bibechana-80853	82	43	the	the	DET
bibechana-80853	82	44	ligand	ligand	NOUN
bibechana-80853	82	45	's	's	PART
bibechana-80853	82	46	https://www.dockthor.lncc.br/	https://www.dockthor.lncc.br/	NOUN
bibechana-80853	82	47	ram	ram	PROPN
bibechana-80853	82	48	lal	lal	PROPN
bibechana-80853	82	49	(	(	PUNCT
bibechana-80853	82	50	swagat	swagat	ADJ
bibechana-80853	82	51	)	)	PUNCT
bibechana-80853	82	52	shrestha	shrestha	NOUN
bibechana-80853	82	53	et	et	PROPN
bibechana-80853	83	1	al./	al./	ADV
bibechana-80853	83	2	bibechana	bibechana	PROPN
bibechana-80853	83	3	22	22	NUM
bibechana-80853	83	4	(	(	PUNCT
bibechana-80853	83	5	2025	2025	NUM
bibechana-80853	83	6	)	)	PUNCT
bibechana-80853	83	7	291	291	NUM
bibechana-80853	83	8	-	-	SYM
bibechana-80853	83	9	298	298	NUM
bibechana-80853	83	10	294	294	NUM
bibechana-80853	83	11	binding	bind	VERB
bibechana-80853	83	12	pose	pose	NOUN
bibechana-80853	83	13	(	(	PUNCT
bibechana-80853	83	14	figure	figure	NOUN
bibechana-80853	83	15	1	1	NUM
bibechana-80853	83	16	)	)	PUNCT
bibechana-80853	83	17	.	.	PUNCT
bibechana-80853	84	1	the	the	DET
bibechana-80853	84	2	parameters	parameter	NOUN
bibechana-80853	84	3	were	be	AUX
bibechana-80853	84	4	determined	determine	VERB
bibechana-80853	84	5	to	to	PART
bibechana-80853	84	6	be	be	AUX
bibechana-80853	84	7	effective	effective	ADJ
bibechana-80853	84	8	in	in	ADP
bibechana-80853	84	9	capturing	capture	VERB
bibechana-80853	84	10	the	the	DET
bibechana-80853	84	11	presumed	presume	VERB
bibechana-80853	84	12	global	global	ADJ
bibechana-80853	84	13	minima	minima	NOUN
bibechana-80853	84	14	of	of	ADP
bibechana-80853	84	15	the	the	DET
bibechana-80853	84	16	protein	protein	NOUN
bibechana-80853	84	17	-	-	PUNCT
bibechana-80853	84	18	ligand	ligand	NOUN
bibechana-80853	84	19	adduct	adduct	NOUN
bibechana-80853	84	20	.	.	PUNCT
bibechana-80853	85	1	3.2	3.2	NUM
bibechana-80853	85	2	binding	bind	VERB
bibechana-80853	85	3	affinity	affinity	NOUN
bibechana-80853	85	4	and	and	CCONJ
bibechana-80853	85	5	strength	strength	NOUN
bibechana-80853	85	6	of	of	ADP
bibechana-80853	85	7	interactions	interaction	NOUN
bibechana-80853	85	8	the	the	DET
bibechana-80853	85	9	binding	bind	VERB
bibechana-80853	85	10	affinity	affinity	NOUN
bibechana-80853	85	11	of	of	ADP
bibechana-80853	85	12	-9.691	-9.691	PROPN
bibechana-80853	85	13	kcal	kcal	PROPN
bibechana-80853	85	14	/	/	SYM
bibechana-80853	85	15	mol	mol	NOUN
bibechana-80853	85	16	found	find	VERB
bibechana-80853	85	17	by	by	ADP
bibechana-80853	85	18	the	the	DET
bibechana-80853	85	19	docking	docking	NOUN
bibechana-80853	85	20	of	of	ADP
bibechana-80853	85	21	the	the	DET
bibechana-80853	85	22	native	native	ADJ
bibechana-80853	85	23	ligand	ligand	NOUN
bibechana-80853	85	24	against	against	ADP
bibechana-80853	85	25	the	the	DET
bibechana-80853	85	26	target	target	NOUN
bibechana-80853	85	27	suggested	suggest	VERB
bibechana-80853	85	28	a	a	DET
bibechana-80853	85	29	strong	strong	ADJ
bibechana-80853	85	30	interaction	interaction	NOUN
bibechana-80853	85	31	(	(	PUNCT
bibechana-80853	85	32	table	table	NOUN
bibechana-80853	85	33	2	2	NUM
bibechana-80853	85	34	)	)	PUNCT
bibechana-80853	85	35	.	.	PUNCT
bibechana-80853	86	1	the	the	DET
bibechana-80853	86	2	lower	low	ADJ
bibechana-80853	86	3	(	(	PUNCT
bibechana-80853	86	4	more	more	ADV
bibechana-80853	86	5	negative	negative	ADJ
bibechana-80853	86	6	)	)	PUNCT
bibechana-80853	86	7	the	the	DET
bibechana-80853	86	8	binding	bind	VERB
bibechana-80853	86	9	energy	energy	NOUN
bibechana-80853	86	10	,	,	PUNCT
bibechana-80853	86	11	the	the	DET
bibechana-80853	86	12	more	more	ADV
bibechana-80853	86	13	stable	stable	ADJ
bibechana-80853	86	14	and	and	CCONJ
bibechana-80853	86	15	stronger	strong	ADJ
bibechana-80853	86	16	the	the	DET
bibechana-80853	86	17	binding	binding	NOUN
bibechana-80853	86	18	between	between	ADP
bibechana-80853	86	19	molecules	molecule	NOUN
bibechana-80853	86	20	[	[	X
bibechana-80853	86	21	38	38	NUM
bibechana-80853	86	22	]	]	PUNCT
bibechana-80853	86	23	.	.	PUNCT
bibechana-80853	87	1	among	among	ADP
bibechana-80853	87	2	the	the	DET
bibechana-80853	87	3	proposed	propose	VERB
bibechana-80853	87	4	compounds	compound	NOUN
bibechana-80853	87	5	,	,	PUNCT
bibechana-80853	87	6	astragalin	astragalin	PROPN
bibechana-80853	87	7	(	(	PUNCT
bibechana-80853	87	8	complex	complex	ADJ
bibechana-80853	87	9	1	1	NUM
bibechana-80853	87	10	)	)	PUNCT
bibechana-80853	87	11	exhibited	exhibit	VERB
bibechana-80853	87	12	the	the	DET
bibechana-80853	87	13	best	well	ADV
bibechana-80853	87	14	binding	bind	VERB
bibechana-80853	87	15	affinity	affinity	NOUN
bibechana-80853	87	16	of	of	ADP
bibechana-80853	87	17	-9.209	-9.209	PROPN
bibechana-80853	87	18	kcal	kcal	PROPN
bibechana-80853	87	19	/	/	SYM
bibechana-80853	87	20	mol	mol	PROPN
bibechana-80853	87	21	,	,	PUNCT
bibechana-80853	87	22	which	which	PRON
bibechana-80853	87	23	is	be	AUX
bibechana-80853	87	24	the	the	DET
bibechana-80853	87	25	closest	close	ADJ
bibechana-80853	87	26	to	to	ADP
bibechana-80853	87	27	that	that	PRON
bibechana-80853	87	28	of	of	ADP
bibechana-80853	87	29	the	the	DET
bibechana-80853	87	30	native	native	ADJ
bibechana-80853	87	31	ligand	ligand	NOUN
bibechana-80853	87	32	.	.	PUNCT
bibechana-80853	88	1	similarly	similarly	ADV
bibechana-80853	88	2	,	,	PUNCT
bibechana-80853	88	3	complex	complex	ADJ
bibechana-80853	88	4	2	2	NUM
bibechana-80853	88	5	(	(	PUNCT
bibechana-80853	88	6	patuletin	patuletin	NOUN
bibechana-80853	88	7	)	)	PUNCT
bibechana-80853	88	8	demonstrated	demonstrate	VERB
bibechana-80853	88	9	a	a	DET
bibechana-80853	88	10	binding	bind	VERB
bibechana-80853	88	11	affinity	affinity	NOUN
bibechana-80853	88	12	of	of	ADP
bibechana-80853	88	13	-8.572	-8.572	X
bibechana-80853	88	14	kcal	kcal	NOUN
bibechana-80853	88	15	/	/	SYM
bibechana-80853	88	16	mol	mol	NOUN
bibechana-80853	88	17	indicating	indicate	VERB
bibechana-80853	88	18	slightly	slightly	ADV
bibechana-80853	88	19	weaker	weak	ADJ
bibechana-80853	88	20	interactions	interaction	NOUN
bibechana-80853	88	21	as	as	ADP
bibechana-80853	88	22	compared	compare	VERB
bibechana-80853	88	23	to	to	ADP
bibechana-80853	88	24	complex	complex	ADJ
bibechana-80853	88	25	1	1	NUM
bibechana-80853	88	26	.	.	PUNCT
bibechana-80853	88	27	figure	figure	NOUN
bibechana-80853	88	28	1	1	NUM
bibechana-80853	88	29	:	:	PUNCT
bibechana-80853	88	30	superimposition	superimposition	NOUN
bibechana-80853	88	31	of	of	ADP
bibechana-80853	88	32	co	co	VERB
bibechana-80853	88	33	-	-	ADJ
bibechana-80853	88	34	crystalized	crystalize	VERB
bibechana-80853	88	35	native	native	ADJ
bibechana-80853	88	36	ligand	ligand	NOUN
bibechana-80853	88	37	6q0	6q0	NUM
bibechana-80853	88	38	(	(	PUNCT
bibechana-80853	88	39	brown	brown	NOUN
bibechana-80853	88	40	)	)	PUNCT
bibechana-80853	88	41	with	with	ADP
bibechana-80853	88	42	docked	docked	ADJ
bibechana-80853	88	43	ligand	ligand	NOUN
bibechana-80853	88	44	(	(	PUNCT
bibechana-80853	88	45	green	green	ADJ
bibechana-80853	88	46	)	)	PUNCT
bibechana-80853	88	47	(	(	PUNCT
bibechana-80853	88	48	heavy	heavy	ADJ
bibechana-80853	88	49	atom	atom	NOUN
bibechana-80853	88	50	rmsd=	rmsd=	NUM
bibechana-80853	88	51	1.79	1.79	NUM
bibechana-80853	88	52	å	å	NOUN
bibechana-80853	88	53	)	)	PUNCT
bibechana-80853	88	54	.	.	PUNCT
bibechana-80853	89	1	3.3	3.3	NUM
bibechana-80853	89	2	present	present	NOUN
bibechana-80853	89	3	in	in	ADP
bibechana-80853	89	4	the	the	DET
bibechana-80853	89	5	protein	protein	NOUN
bibechana-80853	89	6	-	-	PUNCT
bibechana-80853	89	7	ligand	ligand	NOUN
bibechana-80853	89	8	complexes	complex	NOUN
bibechana-80853	89	9	proteins	protein	NOUN
bibechana-80853	89	10	interact	interact	VERB
bibechana-80853	89	11	with	with	ADP
bibechana-80853	89	12	other	other	ADJ
bibechana-80853	89	13	small	small	ADJ
bibechana-80853	89	14	molecules	molecule	NOUN
bibechana-80853	89	15	to	to	PART
bibechana-80853	89	16	enhance	enhance	VERB
bibechana-80853	89	17	or	or	CCONJ
bibechana-80853	89	18	inhibit	inhibit	VERB
bibechana-80853	89	19	biological	biological	ADJ
bibechana-80853	89	20	functions	function	NOUN
bibechana-80853	89	21	.	.	PUNCT
bibechana-80853	90	1	in	in	ADP
bibechana-80853	90	2	proteinligand	proteinligand	ADJ
bibechana-80853	90	3	interactions	interaction	NOUN
bibechana-80853	90	4	,	,	PUNCT
bibechana-80853	90	5	a	a	DET
bibechana-80853	90	6	few	few	ADJ
bibechana-80853	90	7	key	key	ADJ
bibechana-80853	90	8	residues	residue	NOUN
bibechana-80853	90	9	play	play	VERB
bibechana-80853	90	10	a	a	DET
bibechana-80853	90	11	pivotal	pivotal	ADJ
bibechana-80853	90	12	role	role	NOUN
bibechana-80853	90	13	in	in	ADP
bibechana-80853	90	14	recognizing	recognize	VERB
bibechana-80853	90	15	counterparts	counterpart	NOUN
bibechana-80853	90	16	and	and	CCONJ
bibechana-80853	90	17	maintaining	maintain	VERB
bibechana-80853	90	18	the	the	DET
bibechana-80853	90	19	affinity	affinity	NOUN
bibechana-80853	90	20	that	that	PRON
bibechana-80853	90	21	binds	bind	VERB
bibechana-80853	90	22	the	the	DET
bibechana-80853	90	23	ligand	ligand	NOUN
bibechana-80853	90	24	to	to	ADP
bibechana-80853	90	25	its	its	PRON
bibechana-80853	90	26	receptor	receptor	NOUN
bibechana-80853	90	27	[	[	X
bibechana-80853	90	28	39	39	NUM
bibechana-80853	90	29	]	]	PUNCT
bibechana-80853	90	30	.	.	PUNCT
bibechana-80853	91	1	identifying	identify	VERB
bibechana-80853	91	2	these	these	DET
bibechana-80853	91	3	key	key	ADJ
bibechana-80853	91	4	residues	residue	NOUN
bibechana-80853	91	5	is	be	AUX
bibechana-80853	91	6	essential	essential	ADJ
bibechana-80853	91	7	for	for	ADP
bibechana-80853	91	8	understanding	understand	VERB
bibechana-80853	91	9	protein	protein	NOUN
bibechana-80853	91	10	function	function	NOUN
bibechana-80853	91	11	,	,	PUNCT
bibechana-80853	91	12	analyzing	analyze	VERB
bibechana-80853	91	13	molecular	molecular	ADJ
bibechana-80853	91	14	interactions	interaction	NOUN
bibechana-80853	91	15	,	,	PUNCT
bibechana-80853	91	16	and	and	CCONJ
bibechana-80853	91	17	guiding	guide	VERB
bibechana-80853	91	18	future	future	ADJ
bibechana-80853	91	19	experimental	experimental	ADJ
bibechana-80853	91	20	procedures	procedure	NOUN
bibechana-80853	91	21	[	[	X
bibechana-80853	91	22	40	40	NUM
bibechana-80853	91	23	]	]	PUNCT
bibechana-80853	91	24	.	.	PUNCT
bibechana-80853	92	1	the	the	DET
bibechana-80853	92	2	interactions	interaction	NOUN
bibechana-80853	92	3	between	between	ADP
bibechana-80853	92	4	different	different	ADJ
bibechana-80853	92	5	ligands	ligand	NOUN
bibechana-80853	92	6	and	and	CCONJ
bibechana-80853	92	7	the	the	DET
bibechana-80853	92	8	target	target	NOUN
bibechana-80853	92	9	are	be	AUX
bibechana-80853	92	10	illustrated	illustrate	VERB
bibechana-80853	92	11	in	in	ADP
bibechana-80853	92	12	figure	figure	NOUN
bibechana-80853	92	13	2	2	NUM
bibechana-80853	92	14	.	.	PUNCT
bibechana-80853	92	15	table	table	NOUN
bibechana-80853	92	16	2	2	NUM
bibechana-80853	92	17	shows	show	VERB
bibechana-80853	92	18	that	that	SCONJ
bibechana-80853	92	19	the	the	DET
bibechana-80853	92	20	native	native	ADJ
bibechana-80853	92	21	ligand	ligand	NOUN
bibechana-80853	92	22	formed	form	VERB
bibechana-80853	92	23	hydrogen	hydrogen	NOUN
bibechana-80853	92	24	bonds	bond	NOUN
bibechana-80853	92	25	with	with	ADP
bibechana-80853	92	26	arg817	arg817	PROPN
bibechana-80853	92	27	at	at	ADP
bibechana-80853	92	28	a	a	DET
bibechana-80853	92	29	distance	distance	NOUN
bibechana-80853	92	30	of	of	ADP
bibechana-80853	92	31	3.29	3.29	NUM
bibechana-80853	92	32	å	å	NOUN
bibechana-80853	92	33	.	.	PUNCT
bibechana-80853	93	1	the	the	DET
bibechana-80853	93	2	distances	distance	NOUN
bibechana-80853	93	3	between	between	ADP
bibechana-80853	93	4	the	the	DET
bibechana-80853	93	5	ligand	ligand	NOUN
bibechana-80853	93	6	and	and	CCONJ
bibechana-80853	93	7	the	the	DET
bibechana-80853	93	8	amino	amino	NOUN
bibechana-80853	93	9	acids	acid	NOUN
bibechana-80853	93	10	reveal	reveal	VERB
bibechana-80853	93	11	the	the	DET
bibechana-80853	93	12	proximity	proximity	NOUN
bibechana-80853	93	13	of	of	ADP
bibechana-80853	93	14	their	their	PRON
bibechana-80853	93	15	interaction	interaction	NOUN
bibechana-80853	93	16	within	within	ADP
bibechana-80853	93	17	the	the	DET
bibechana-80853	93	18	protein	protein	NOUN
bibechana-80853	93	19	binding	bind	VERB
bibechana-80853	93	20	site	site	NOUN
bibechana-80853	93	21	.	.	PUNCT
bibechana-80853	94	1	the	the	DET
bibechana-80853	94	2	shorter	short	ADJ
bibechana-80853	94	3	the	the	DET
bibechana-80853	94	4	distance	distance	NOUN
bibechana-80853	94	5	,	,	PUNCT
bibechana-80853	94	6	the	the	PRON
bibechana-80853	94	7	stronger	strong	ADJ
bibechana-80853	94	8	the	the	DET
bibechana-80853	94	9	interaction	interaction	NOUN
bibechana-80853	94	10	.	.	PUNCT
bibechana-80853	95	1	in	in	ADP
bibechana-80853	95	2	this	this	DET
bibechana-80853	95	3	context	context	NOUN
bibechana-80853	95	4	,	,	PUNCT
bibechana-80853	95	5	the	the	DET
bibechana-80853	95	6	h	h	NOUN
bibechana-80853	95	7	-	-	PUNCT
bibechana-80853	95	8	bonding	bond	VERB
bibechana-80853	95	9	interaction	interaction	NOUN
bibechana-80853	95	10	involving	involve	VERB
bibechana-80853	95	11	leu769	leu769	PROPN
bibechana-80853	95	12	in	in	ADP
bibechana-80853	95	13	complex	complex	ADJ
bibechana-80853	95	14	1	1	NUM
bibechana-80853	95	15	,	,	PUNCT
bibechana-80853	95	16	with	with	ADP
bibechana-80853	95	17	a	a	DET
bibechana-80853	95	18	distance	distance	NOUN
bibechana-80853	95	19	of	of	ADP
bibechana-80853	95	20	1.71	1.71	NUM
bibechana-80853	95	21	å	å	NOUN
bibechana-80853	95	22	,	,	PUNCT
bibechana-80853	95	23	can	can	AUX
bibechana-80853	95	24	be	be	AUX
bibechana-80853	95	25	considered	consider	VERB
bibechana-80853	95	26	the	the	DET
bibechana-80853	95	27	strongest	strong	ADJ
bibechana-80853	95	28	overall	overall	NOUN
bibechana-80853	95	29	.	.	PUNCT
bibechana-80853	96	1	similarly	similarly	ADV
bibechana-80853	96	2	,	,	PUNCT
bibechana-80853	96	3	the	the	DET
bibechana-80853	96	4	interaction	interaction	NOUN
bibechana-80853	96	5	with	with	ADP
bibechana-80853	96	6	met807	met807	PROPN
bibechana-80853	96	7	in	in	ADP
bibechana-80853	96	8	complex	complex	ADJ
bibechana-80853	96	9	2	2	NUM
bibechana-80853	96	10	is	be	AUX
bibechana-80853	96	11	the	the	DET
bibechana-80853	96	12	strongest	strong	ADJ
bibechana-80853	96	13	among	among	ADP
bibechana-80853	96	14	all	all	DET
bibechana-80853	96	15	residues	residue	NOUN
bibechana-80853	96	16	,	,	PUNCT
bibechana-80853	96	17	with	with	ADP
bibechana-80853	96	18	a	a	DET
bibechana-80853	96	19	distance	distance	NOUN
bibechana-80853	96	20	of	of	ADP
bibechana-80853	96	21	just	just	ADV
bibechana-80853	96	22	1.92	1.92	NUM
bibechana-80853	96	23	å	å	NOUN
bibechana-80853	96	24	.	.	PUNCT
bibechana-80853	97	1	the	the	DET
bibechana-80853	97	2	key	key	ADJ
bibechana-80853	97	3	amino	amino	NOUN
bibechana-80853	97	4	acid	acid	NOUN
bibechana-80853	97	5	residues	residue	NOUN
bibechana-80853	97	6	(	(	PUNCT
bibechana-80853	97	7	arg817	arg817	PROPN
bibechana-80853	97	8	,	,	PUNCT
bibechana-80853	97	9	trp806	trp806	PROPN
bibechana-80853	97	10	,	,	PUNCT
bibechana-80853	97	11	leu769	leu769	PROPN
bibechana-80853	97	12	)	)	PUNCT
bibechana-80853	97	13	involved	involve	VERB
bibechana-80853	97	14	in	in	ADP
bibechana-80853	97	15	the	the	DET
bibechana-80853	97	16	interactions	interaction	NOUN
bibechana-80853	97	17	between	between	ADP
bibechana-80853	97	18	astragalin	astragalin	PROPN
bibechana-80853	97	19	(	(	PUNCT
bibechana-80853	97	20	complex	complex	ADJ
bibechana-80853	97	21	1	1	NUM
bibechana-80853	97	22	)	)	PUNCT
bibechana-80853	97	23	and	and	CCONJ
bibechana-80853	97	24	the	the	DET
bibechana-80853	97	25	target	target	NOUN
bibechana-80853	97	26	protein	protein	NOUN
bibechana-80853	97	27	are	be	AUX
bibechana-80853	97	28	nearly	nearly	ADV
bibechana-80853	97	29	identical	identical	ADJ
bibechana-80853	97	30	to	to	ADP
bibechana-80853	97	31	those	those	PRON
bibechana-80853	97	32	observed	observe	VERB
bibechana-80853	97	33	in	in	ADP
bibechana-80853	97	34	the	the	DET
bibechana-80853	97	35	interaction	interaction	NOUN
bibechana-80853	97	36	between	between	ADP
bibechana-80853	97	37	the	the	DET
bibechana-80853	97	38	native	native	ADJ
bibechana-80853	97	39	ligand	ligand	NOUN
bibechana-80853	97	40	and	and	CCONJ
bibechana-80853	97	41	the	the	DET
bibechana-80853	97	42	protein	protein	NOUN
bibechana-80853	97	43	.	.	PUNCT
bibechana-80853	98	1	this	this	PRON
bibechana-80853	98	2	suggests	suggest	VERB
bibechana-80853	98	3	that	that	SCONJ
bibechana-80853	98	4	the	the	DET
bibechana-80853	98	5	ligand	ligand	NOUN
bibechana-80853	98	6	binds	bind	VERB
bibechana-80853	98	7	at	at	ADP
bibechana-80853	98	8	the	the	DET
bibechana-80853	98	9	catalytic	catalytic	ADJ
bibechana-80853	98	10	site	site	NOUN
bibechana-80853	98	11	of	of	ADP
bibechana-80853	98	12	the	the	DET
bibechana-80853	98	13	protein	protein	NOUN
bibechana-80853	98	14	and	and	CCONJ
bibechana-80853	98	15	is	be	AUX
bibechana-80853	98	16	therefore	therefore	ADV
bibechana-80853	98	17	capable	capable	ADJ
bibechana-80853	98	18	of	of	ADP
bibechana-80853	98	19	modulating	modulate	VERB
bibechana-80853	98	20	it	it	PRON
bibechana-80853	98	21	.	.	PUNCT
bibechana-80853	99	1	(	(	PUNCT
bibechana-80853	99	2	native	native	ADJ
bibechana-80853	99	3	)	)	PUNCT
bibechana-80853	99	4	(	(	PUNCT
bibechana-80853	99	5	1	1	X
bibechana-80853	99	6	)	)	PUNCT
bibechana-80853	99	7	(	(	PUNCT
bibechana-80853	99	8	2	2	X
bibechana-80853	99	9	)	)	PUNCT
bibechana-80853	99	10	figure	figure	NOUN
bibechana-80853	99	11	2	2	NUM
bibechana-80853	99	12	:	:	PUNCT
bibechana-80853	99	13	3d	3d	NUM
bibechana-80853	99	14	interactive	interactive	ADJ
bibechana-80853	99	15	representations	representation	NOUN
bibechana-80853	99	16	of	of	ADP
bibechana-80853	99	17	the	the	DET
bibechana-80853	99	18	key	key	ADJ
bibechana-80853	99	19	interactions	interaction	NOUN
bibechana-80853	99	20	of	of	ADP
bibechana-80853	99	21	the	the	DET
bibechana-80853	99	22	ligand	ligand	NOUN
bibechana-80853	99	23	with	with	ADP
bibechana-80853	99	24	active	active	ADJ
bibechana-80853	99	25	site	site	NOUN
bibechana-80853	99	26	residues	residue	NOUN
bibechana-80853	99	27	in	in	ADP
bibechana-80853	99	28	protein	protein	NOUN
bibechana-80853	99	29	-	-	PUNCT
bibechana-80853	99	30	ligand	ligand	NOUN
bibechana-80853	99	31	complex	complex	NOUN
bibechana-80853	99	32	(	(	PUNCT
bibechana-80853	99	33	native	native	ADJ
bibechana-80853	99	34	,	,	PUNCT
bibechana-80853	99	35	1	1	NUM
bibechana-80853	99	36	(	(	PUNCT
bibechana-80853	99	37	astragalin	astragalin	ADJ
bibechana-80853	99	38	)	)	PUNCT
bibechana-80853	99	39	,	,	PUNCT
bibechana-80853	99	40	and	and	CCONJ
bibechana-80853	99	41	2	2	NUM
bibechana-80853	99	42	(	(	PUNCT
bibechana-80853	99	43	patuletin	patuletin	NOUN
bibechana-80853	99	44	)	)	PUNCT
bibechana-80853	99	45	)	)	PUNCT
bibechana-80853	99	46	.	.	PUNCT
bibechana-80853	100	1	ram	ram	PROPN
bibechana-80853	100	2	lal	lal	PROPN
bibechana-80853	100	3	(	(	PUNCT
bibechana-80853	100	4	swagat	swagat	ADJ
bibechana-80853	100	5	)	)	PUNCT
bibechana-80853	100	6	shrestha	shrestha	NOUN
bibechana-80853	100	7	et	et	PROPN
bibechana-80853	101	1	al./	al./	ADV
bibechana-80853	101	2	bibechana	bibechana	PROPN
bibechana-80853	101	3	22	22	NUM
bibechana-80853	101	4	(	(	PUNCT
bibechana-80853	101	5	2025	2025	NUM
bibechana-80853	101	6	)	)	PUNCT
bibechana-80853	101	7	291	291	NUM
bibechana-80853	101	8	-	-	SYM
bibechana-80853	101	9	298	298	NUM
bibechana-80853	101	10	295	295	NUM
bibechana-80853	101	11	3.4	3.4	NUM
bibechana-80853	101	12	admet	admet	NOUN
bibechana-80853	101	13	analysis	analysis	NOUN
bibechana-80853	101	14	the	the	DET
bibechana-80853	101	15	admet	admet	PROPN
bibechana-80853	101	16	data	datum	NOUN
bibechana-80853	101	17	via	via	ADP
bibechana-80853	101	18	the	the	DET
bibechana-80853	101	19	swissadme	swissadme	PROPN
bibechana-80853	101	20	server	server	NOUN
bibechana-80853	101	21	and	and	CCONJ
bibechana-80853	101	22	its	its	PRON
bibechana-80853	101	23	analysis	analysis	NOUN
bibechana-80853	101	24	provided	provide	VERB
bibechana-80853	101	25	key	key	ADJ
bibechana-80853	101	26	insights	insight	NOUN
bibechana-80853	101	27	into	into	ADP
bibechana-80853	101	28	the	the	DET
bibechana-80853	101	29	absorption	absorption	NOUN
bibechana-80853	101	30	properties	property	NOUN
bibechana-80853	101	31	of	of	ADP
bibechana-80853	101	32	the	the	DET
bibechana-80853	101	33	molecules	molecule	NOUN
bibechana-80853	101	34	.	.	PUNCT
bibechana-80853	102	1	molecules	molecule	NOUN
bibechana-80853	102	2	(	(	PUNCT
bibechana-80853	102	3	triacontane	triacontane	NOUN
bibechana-80853	102	4	and	and	CCONJ
bibechana-80853	102	5	hentriacontane	hentriacontane	NOUN
bibechana-80853	102	6	)	)	PUNCT
bibechana-80853	102	7	were	be	AUX
bibechana-80853	102	8	found	find	VERB
bibechana-80853	102	9	to	to	PART
bibechana-80853	102	10	be	be	AUX
bibechana-80853	102	11	insoluble	insoluble	ADJ
bibechana-80853	102	12	with	with	ADP
bibechana-80853	102	13	low	low	ADJ
bibechana-80853	102	14	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	102	15	(	(	PUNCT
bibechana-80853	102	16	gi	gi	NOUN
bibechana-80853	102	17	)	)	PUNCT
bibechana-80853	102	18	absorption	absorption	NOUN
bibechana-80853	102	19	.	.	PUNCT
bibechana-80853	103	1	their	their	PRON
bibechana-80853	103	2	high	high	ADJ
bibechana-80853	103	3	lipophilicity	lipophilicity	NOUN
bibechana-80853	103	4	(	(	PUNCT
bibechana-80853	103	5	logp	logp	NOUN
bibechana-80853	103	6	of	of	ADP
bibechana-80853	103	7	11.95	11.95	NUM
bibechana-80853	103	8	and	and	CCONJ
bibechana-80853	103	9	12.34	12.34	NUM
bibechana-80853	103	10	,	,	PUNCT
bibechana-80853	103	11	respectively	respectively	ADV
bibechana-80853	103	12	)	)	PUNCT
bibechana-80853	103	13	poses	pose	VERB
bibechana-80853	103	14	formulation	formulation	NOUN
bibechana-80853	103	15	and	and	CCONJ
bibechana-80853	103	16	absorption	absorption	NOUN
bibechana-80853	103	17	challenges	challenge	NOUN
bibechana-80853	103	18	.	.	PUNCT
bibechana-80853	104	1	in	in	ADP
bibechana-80853	104	2	contrast	contrast	NOUN
bibechana-80853	104	3	,	,	PUNCT
bibechana-80853	104	4	palmitic	palmitic	ADJ
bibechana-80853	104	5	acid	acid	NOUN
bibechana-80853	104	6	displayed	display	VERB
bibechana-80853	104	7	high	high	ADJ
bibechana-80853	104	8	gi	gi	NOUN
bibechana-80853	104	9	absorption	absorption	NOUN
bibechana-80853	104	10	,	,	PUNCT
bibechana-80853	104	11	along	along	ADP
bibechana-80853	104	12	with	with	ADP
bibechana-80853	104	13	moderate	moderate	ADJ
bibechana-80853	104	14	solubility	solubility	NOUN
bibechana-80853	104	15	and	and	CCONJ
bibechana-80853	104	16	permeability	permeability	NOUN
bibechana-80853	104	17	across	across	ADP
bibechana-80853	104	18	the	the	DET
bibechana-80853	104	19	blood	blood	NOUN
bibechana-80853	104	20	-	-	PUNCT
bibechana-80853	104	21	brain	brain	NOUN
bibechana-80853	104	22	barrier	barrier	NOUN
bibechana-80853	104	23	(	(	PUNCT
bibechana-80853	104	24	bbb	bbb	PROPN
bibechana-80853	104	25	)	)	PUNCT
bibechana-80853	104	26	,	,	PUNCT
bibechana-80853	104	27	making	make	VERB
bibechana-80853	104	28	it	it	PRON
bibechana-80853	104	29	a	a	DET
bibechana-80853	104	30	promising	promising	ADJ
bibechana-80853	104	31	candidate	candidate	NOUN
bibechana-80853	104	32	.	.	PUNCT
bibechana-80853	105	1	bersaldegenin3	bersaldegenin3	PROPN
bibechana-80853	105	2	-	-	PUNCT
bibechana-80853	105	3	acetate	acetate	NOUN
bibechana-80853	105	4	,	,	PUNCT
bibechana-80853	105	5	while	while	SCONJ
bibechana-80853	105	6	soluble	soluble	ADJ
bibechana-80853	105	7	and	and	CCONJ
bibechana-80853	105	8	showing	show	VERB
bibechana-80853	105	9	high	high	ADJ
bibechana-80853	105	10	gi	gi	NOUN
bibechana-80853	105	11	absorption	absorption	NOUN
bibechana-80853	105	12	,	,	PUNCT
bibechana-80853	105	13	was	be	AUX
bibechana-80853	105	14	not	not	PART
bibechana-80853	105	15	bbb	bbb	NOUN
bibechana-80853	105	16	permeant	permeant	ADJ
bibechana-80853	105	17	and	and	CCONJ
bibechana-80853	105	18	had	have	VERB
bibechana-80853	105	19	moderate	moderate	ADJ
bibechana-80853	105	20	lipophilicity	lipophilicity	NOUN
bibechana-80853	105	21	(	(	PUNCT
bibechana-80853	105	22	logp	logp	NOUN
bibechana-80853	105	23	of	of	ADP
bibechana-80853	105	24	2.08	2.08	NUM
bibechana-80853	105	25	)	)	PUNCT
bibechana-80853	105	26	.	.	PUNCT
bibechana-80853	106	1	most	most	ADJ
bibechana-80853	106	2	of	of	ADP
bibechana-80853	106	3	the	the	DET
bibechana-80853	106	4	molecules	molecule	NOUN
bibechana-80853	106	5	adhered	adhere	VERB
bibechana-80853	106	6	to	to	ADP
bibechana-80853	106	7	lipinski	lipinski	PROPN
bibechana-80853	106	8	's	's	PART
bibechana-80853	106	9	rule	rule	NOUN
bibechana-80853	106	10	of	of	ADP
bibechana-80853	106	11	five	five	NUM
bibechana-80853	106	12	,	,	PUNCT
bibechana-80853	106	13	except	except	SCONJ
bibechana-80853	106	14	astragalin	astragalin	PROPN
bibechana-80853	106	15	,	,	PUNCT
bibechana-80853	106	16	which	which	PRON
bibechana-80853	106	17	had	have	VERB
bibechana-80853	106	18	a	a	DET
bibechana-80853	106	19	high	high	ADJ
bibechana-80853	106	20	topological	topological	ADJ
bibechana-80853	106	21	polar	polar	ADJ
bibechana-80853	106	22	surface	surface	NOUN
bibechana-80853	106	23	area	area	NOUN
bibechana-80853	106	24	(	(	PUNCT
bibechana-80853	106	25	tpsa	tpsa	NOUN
bibechana-80853	106	26	)	)	PUNCT
bibechana-80853	106	27	of	of	ADP
bibechana-80853	106	28	190.28	190.28	NUM
bibechana-80853	106	29	å²	å²	PROPN
bibechana-80853	106	30	and	and	CCONJ
bibechana-80853	106	31	a	a	DET
bibechana-80853	106	32	low	low	ADJ
bibechana-80853	106	33	logp	logp	NOUN
bibechana-80853	106	34	value	value	NOUN
bibechana-80853	106	35	of	of	ADP
bibechana-80853	106	36	-0.24	-0.24	NOUN
bibechana-80853	106	37	,	,	PUNCT
bibechana-80853	106	38	making	make	VERB
bibechana-80853	106	39	it	it	PRON
bibechana-80853	106	40	unable	unable	ADJ
bibechana-80853	106	41	to	to	PART
bibechana-80853	106	42	permeate	permeate	VERB
bibechana-80853	106	43	the	the	DET
bibechana-80853	106	44	gi	gi	NOUN
bibechana-80853	106	45	tract	tract	NOUN
bibechana-80853	106	46	and	and	CCONJ
bibechana-80853	106	47	,	,	PUNCT
bibechana-80853	106	48	therefore	therefore	ADV
bibechana-80853	106	49	,	,	PUNCT
bibechana-80853	106	50	unlikely	unlikely	ADJ
bibechana-80853	106	51	to	to	PART
bibechana-80853	106	52	enter	enter	VERB
bibechana-80853	106	53	the	the	DET
bibechana-80853	106	54	bloodstream	bloodstream	NOUN
bibechana-80853	107	1	[	[	X
bibechana-80853	107	2	41	41	NUM
bibechana-80853	107	3	]	]	PUNCT
bibechana-80853	107	4	(	(	PUNCT
bibechana-80853	107	5	table	table	NOUN
bibechana-80853	107	6	3	3	NUM
bibechana-80853	107	7	)	)	PUNCT
bibechana-80853	107	8	.	.	PUNCT
bibechana-80853	108	1	the	the	DET
bibechana-80853	108	2	low	low	ADJ
bibechana-80853	108	3	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	108	4	absorption	absorption	NOUN
bibechana-80853	108	5	of	of	ADP
bibechana-80853	108	6	astragalin	astragalin	PROPN
bibechana-80853	108	7	could	could	AUX
bibechana-80853	108	8	potentially	potentially	ADV
bibechana-80853	108	9	be	be	AUX
bibechana-80853	108	10	improved	improve	VERB
bibechana-80853	108	11	through	through	ADP
bibechana-80853	108	12	nanoparticle	nanoparticle	NOUN
bibechana-80853	108	13	delivery	delivery	NOUN
bibechana-80853	108	14	,	,	PUNCT
bibechana-80853	108	15	glycoside	glycoside	NOUN
bibechana-80853	108	16	hydrolysis	hydrolysis	NOUN
bibechana-80853	108	17	,	,	PUNCT
bibechana-80853	108	18	or	or	CCONJ
bibechana-80853	108	19	other	other	ADJ
bibechana-80853	108	20	formulation	formulation	NOUN
bibechana-80853	108	21	strategies	strategy	NOUN
bibechana-80853	108	22	such	such	ADJ
bibechana-80853	108	23	as	as	ADP
bibechana-80853	108	24	lipid	lipid	NOUN
bibechana-80853	108	25	-	-	PUNCT
bibechana-80853	108	26	based	base	VERB
bibechana-80853	108	27	carriers	carrier	NOUN
bibechana-80853	108	28	and	and	CCONJ
bibechana-80853	108	29	prodrug	prodrug	NOUN
bibechana-80853	108	30	approaches	approach	NOUN
bibechana-80853	108	31	.	.	PUNCT
bibechana-80853	109	1	palmitic	palmitic	ADJ
bibechana-80853	109	2	acid	acid	NOUN
bibechana-80853	109	3	and	and	CCONJ
bibechana-80853	109	4	cardenolide	cardenolide	NOUN
bibechana-80853	109	5	were	be	AUX
bibechana-80853	109	6	the	the	DET
bibechana-80853	109	7	only	only	ADJ
bibechana-80853	109	8	compounds	compound	NOUN
bibechana-80853	109	9	identified	identify	VERB
bibechana-80853	109	10	as	as	ADP
bibechana-80853	109	11	bbb	bbb	PROPN
bibechana-80853	109	12	permeant	permeant	NOUN
bibechana-80853	109	13	,	,	PUNCT
bibechana-80853	109	14	indicating	indicate	VERB
bibechana-80853	109	15	their	their	PRON
bibechana-80853	109	16	ability	ability	NOUN
bibechana-80853	109	17	to	to	PART
bibechana-80853	109	18	cross	cross	VERB
bibechana-80853	109	19	the	the	DET
bibechana-80853	109	20	bbb	bbb	NOUN
bibechana-80853	109	21	and	and	CCONJ
bibechana-80853	109	22	potentially	potentially	ADV
bibechana-80853	109	23	target	target	VERB
bibechana-80853	109	24	central	central	ADJ
bibechana-80853	109	25	nervous	nervous	ADJ
bibechana-80853	109	26	system	system	NOUN
bibechana-80853	109	27	(	(	PUNCT
bibechana-80853	109	28	cns	cns	NOUN
bibechana-80853	109	29	)	)	PUNCT
bibechana-80853	109	30	disorders	disorder	NOUN
bibechana-80853	109	31	.	.	PUNCT
bibechana-80853	110	1	however	however	ADV
bibechana-80853	110	2	,	,	PUNCT
bibechana-80853	110	3	the	the	DET
bibechana-80853	110	4	boiled	boil	VERB
bibechana-80853	110	5	-	-	PUNCT
bibechana-80853	110	6	egg	egg	NOUN
bibechana-80853	110	7	model	model	NOUN
bibechana-80853	110	8	,	,	PUNCT
bibechana-80853	110	9	based	base	VERB
bibechana-80853	110	10	on	on	ADP
bibechana-80853	110	11	tpsa	tpsa	NOUN
bibechana-80853	110	12	and	and	CCONJ
bibechana-80853	110	13	logp	logp	NOUN
bibechana-80853	110	14	values	value	NOUN
bibechana-80853	110	15	,	,	PUNCT
bibechana-80853	110	16	revealed	reveal	VERB
bibechana-80853	110	17	that	that	SCONJ
bibechana-80853	110	18	7	7	NUM
bibechana-80853	110	19	out	out	ADP
bibechana-80853	110	20	of	of	ADP
bibechana-80853	110	21	the	the	DET
bibechana-80853	110	22	20	20	NUM
bibechana-80853	110	23	molecules	molecule	NOUN
bibechana-80853	110	24	did	do	AUX
bibechana-80853	110	25	not	not	PART
bibechana-80853	110	26	fall	fall	VERB
bibechana-80853	110	27	within	within	ADP
bibechana-80853	110	28	the	the	DET
bibechana-80853	110	29	specified	specified	ADJ
bibechana-80853	110	30	range	range	NOUN
bibechana-80853	110	31	for	for	ADP
bibechana-80853	110	32	bbb	bbb	PROPN
bibechana-80853	110	33	permeation	permeation	NOUN
bibechana-80853	110	34	or	or	CCONJ
bibechana-80853	110	35	high	high	ADJ
bibechana-80853	110	36	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	110	37	absorption	absorption	NOUN
bibechana-80853	110	38	(	(	PUNCT
bibechana-80853	110	39	supplementary	supplementary	ADJ
bibechana-80853	110	40	figure	figure	NOUN
bibechana-80853	110	41	1	1	NUM
bibechana-80853	110	42	)	)	PUNCT
bibechana-80853	110	43	.	.	PUNCT
bibechana-80853	111	1	this	this	DET
bibechana-80853	111	2	limitation	limitation	NOUN
bibechana-80853	111	3	suggested	suggest	VERB
bibechana-80853	111	4	that	that	SCONJ
bibechana-80853	111	5	these	these	DET
bibechana-80853	111	6	molecules	molecule	NOUN
bibechana-80853	111	7	may	may	AUX
bibechana-80853	111	8	not	not	PART
bibechana-80853	111	9	be	be	AUX
bibechana-80853	111	10	as	as	ADV
bibechana-80853	111	11	effective	effective	ADJ
bibechana-80853	111	12	as	as	SCONJ
bibechana-80853	111	13	orally	orally	ADV
bibechana-80853	111	14	administered	administer	VERB
bibechana-80853	111	15	or	or	CCONJ
bibechana-80853	111	16	cns	cns	NOUN
bibechana-80853	111	17	-	-	PUNCT
bibechana-80853	111	18	targeting	target	VERB
bibechana-80853	111	19	compounds	compound	NOUN
bibechana-80853	111	20	[	[	X
bibechana-80853	111	21	42	42	NUM
bibechana-80853	111	22	]	]	PUNCT
bibechana-80853	111	23	.	.	PUNCT
bibechana-80853	112	1	of	of	ADP
bibechana-80853	112	2	the	the	DET
bibechana-80853	112	3	20	20	NUM
bibechana-80853	112	4	molecules	molecule	NOUN
bibechana-80853	112	5	analyzed	analyze	VERB
bibechana-80853	112	6	,	,	PUNCT
bibechana-80853	112	7	12	12	NUM
bibechana-80853	112	8	did	do	AUX
bibechana-80853	112	9	not	not	PART
bibechana-80853	112	10	inhibit	inhibit	VERB
bibechana-80853	112	11	any	any	PRON
bibechana-80853	112	12	of	of	ADP
bibechana-80853	112	13	the	the	DET
bibechana-80853	112	14	major	major	ADJ
bibechana-80853	112	15	enzymes	enzyme	NOUN
bibechana-80853	112	16	(	(	PUNCT
bibechana-80853	112	17	cyp1a2	cyp1a2	PROPN
bibechana-80853	112	18	,	,	PUNCT
bibechana-80853	112	19	cyp2c19	cyp2c19	PROPN
bibechana-80853	112	20	,	,	PUNCT
bibechana-80853	112	21	cyp2c9	cyp2c9	NOUN
bibechana-80853	112	22	,	,	PUNCT
bibechana-80853	112	23	cyp2d6	cyp2d6	NOUN
bibechana-80853	112	24	,	,	PUNCT
bibechana-80853	112	25	and	and	CCONJ
bibechana-80853	112	26	cyp3a4	cyp3a4	PROPN
bibechana-80853	112	27	)	)	PUNCT
bibechana-80853	112	28	(	(	PUNCT
bibechana-80853	112	29	supplementary	supplementary	ADJ
bibechana-80853	112	30	table	table	NOUN
bibechana-80853	112	31	1	1	NUM
bibechana-80853	112	32	)	)	PUNCT
bibechana-80853	112	33	.	.	PUNCT
bibechana-80853	113	1	this	this	PRON
bibechana-80853	113	2	indicates	indicate	VERB
bibechana-80853	113	3	that	that	SCONJ
bibechana-80853	113	4	these	these	DET
bibechana-80853	113	5	molecules	molecule	NOUN
bibechana-80853	113	6	are	be	AUX
bibechana-80853	113	7	less	less	ADV
bibechana-80853	113	8	likely	likely	ADJ
bibechana-80853	113	9	to	to	PART
bibechana-80853	113	10	disrupt	disrupt	VERB
bibechana-80853	113	11	the	the	DET
bibechana-80853	113	12	metabolism	metabolism	NOUN
bibechana-80853	113	13	of	of	ADP
bibechana-80853	113	14	other	other	ADJ
bibechana-80853	113	15	medications	medication	NOUN
bibechana-80853	113	16	,	,	PUNCT
bibechana-80853	113	17	thereby	thereby	ADV
bibechana-80853	113	18	lowering	lower	VERB
bibechana-80853	113	19	the	the	DET
bibechana-80853	113	20	risk	risk	NOUN
bibechana-80853	113	21	of	of	ADP
bibechana-80853	113	22	drug	drug	NOUN
bibechana-80853	113	23	-	-	PUNCT
bibechana-80853	113	24	drug	drug	NOUN
bibechana-80853	113	25	interactions	interaction	NOUN
bibechana-80853	113	26	[	[	X
bibechana-80853	113	27	43	43	NUM
bibechana-80853	113	28	]	]	PUNCT
bibechana-80853	113	29	.	.	PUNCT
bibechana-80853	114	1	this	this	PRON
bibechana-80853	114	2	is	be	AUX
bibechana-80853	114	3	particularly	particularly	ADV
bibechana-80853	114	4	significant	significant	ADJ
bibechana-80853	114	5	for	for	ADP
bibechana-80853	114	6	patients	patient	NOUN
bibechana-80853	114	7	on	on	ADP
bibechana-80853	114	8	multiple	multiple	ADJ
bibechana-80853	114	9	drugs	drug	NOUN
bibechana-80853	114	10	,	,	PUNCT
bibechana-80853	114	11	as	as	SCONJ
bibechana-80853	114	12	it	it	PRON
bibechana-80853	114	13	suggests	suggest	VERB
bibechana-80853	114	14	that	that	SCONJ
bibechana-80853	114	15	these	these	DET
bibechana-80853	114	16	12	12	NUM
bibechana-80853	114	17	molecules	molecule	NOUN
bibechana-80853	114	18	are	be	AUX
bibechana-80853	114	19	unlikely	unlikely	ADJ
bibechana-80853	114	20	to	to	PART
bibechana-80853	114	21	lead	lead	VERB
bibechana-80853	114	22	to	to	ADP
bibechana-80853	114	23	adverse	adverse	ADJ
bibechana-80853	114	24	effects	effect	NOUN
bibechana-80853	114	25	associated	associate	VERB
bibechana-80853	114	26	with	with	ADP
bibechana-80853	114	27	the	the	DET
bibechana-80853	114	28	buildup	buildup	NOUN
bibechana-80853	114	29	of	of	ADP
bibechana-80853	114	30	other	other	ADJ
bibechana-80853	114	31	drugs	drug	NOUN
bibechana-80853	114	32	metabolized	metabolize	VERB
bibechana-80853	114	33	by	by	ADP
bibechana-80853	114	34	these	these	DET
bibechana-80853	114	35	cyp	cyp	ADJ
bibechana-80853	114	36	enzymes	enzyme	NOUN
bibechana-80853	114	37	[	[	X
bibechana-80853	114	38	44	44	NUM
bibechana-80853	114	39	]	]	PUNCT
bibechana-80853	114	40	.	.	PUNCT
bibechana-80853	115	1	the	the	DET
bibechana-80853	115	2	excretion	excretion	NOUN
bibechana-80853	115	3	properties	property	NOUN
bibechana-80853	115	4	of	of	ADP
bibechana-80853	115	5	the	the	DET
bibechana-80853	115	6	phytocompounds	phytocompound	NOUN
bibechana-80853	115	7	were	be	AUX
bibechana-80853	115	8	evaluated	evaluate	VERB
bibechana-80853	115	9	based	base	VERB
bibechana-80853	115	10	on	on	ADP
bibechana-80853	115	11	their	their	PRON
bibechana-80853	115	12	clearance	clearance	NOUN
bibechana-80853	115	13	rates	rate	NOUN
bibechana-80853	115	14	(	(	PUNCT
bibechana-80853	115	15	ml	ml	NOUN
bibechana-80853	115	16	/	/	SYM
bibechana-80853	115	17	min	min	NOUN
bibechana-80853	115	18	/	/	SYM
bibechana-80853	115	19	kg	kg	PROPN
bibechana-80853	115	20	)	)	PUNCT
bibechana-80853	115	21	,	,	PUNCT
bibechana-80853	115	22	revealing	reveal	VERB
bibechana-80853	115	23	significant	significant	ADJ
bibechana-80853	115	24	differences	difference	NOUN
bibechana-80853	115	25	among	among	ADP
bibechana-80853	115	26	the	the	DET
bibechana-80853	115	27	molecules	molecule	NOUN
bibechana-80853	115	28	.	.	PUNCT
bibechana-80853	116	1	astragalin	astragalin	PROPN
bibechana-80853	116	2	demonstrated	demonstrate	VERB
bibechana-80853	116	3	a	a	DET
bibechana-80853	116	4	low	low	ADJ
bibechana-80853	116	5	clearance	clearance	NOUN
bibechana-80853	116	6	rate	rate	NOUN
bibechana-80853	116	7	of	of	ADP
bibechana-80853	116	8	3.126	3.126	NUM
bibechana-80853	116	9	ml	ml	NOUN
bibechana-80853	116	10	/	/	SYM
bibechana-80853	116	11	min	min	PROPN
bibechana-80853	116	12	/	/	SYM
bibechana-80853	116	13	kg	kg	PROPN
bibechana-80853	116	14	,	,	PUNCT
bibechana-80853	116	15	suggesting	suggest	VERB
bibechana-80853	116	16	that	that	SCONJ
bibechana-80853	116	17	it	it	PRON
bibechana-80853	116	18	remains	remain	VERB
bibechana-80853	116	19	in	in	ADP
bibechana-80853	116	20	the	the	DET
bibechana-80853	116	21	body	body	NOUN
bibechana-80853	116	22	for	for	ADP
bibechana-80853	116	23	a	a	DET
bibechana-80853	116	24	longer	long	ADJ
bibechana-80853	116	25	period	period	NOUN
bibechana-80853	116	26	before	before	ADP
bibechana-80853	116	27	being	be	AUX
bibechana-80853	116	28	eliminated	eliminate	VERB
bibechana-80853	116	29	.	.	PUNCT
bibechana-80853	117	1	in	in	ADP
bibechana-80853	117	2	contrast	contrast	NOUN
bibechana-80853	117	3	,	,	PUNCT
bibechana-80853	117	4	pseudotaraxasterol	pseudotaraxasterol	NOUN
bibechana-80853	117	5	and	and	CCONJ
bibechana-80853	117	6	campesterol	campesterol	NOUN
bibechana-80853	117	7	exhibited	exhibit	VERB
bibechana-80853	117	8	higher	high	ADJ
bibechana-80853	117	9	clearance	clearance	NOUN
bibechana-80853	117	10	rates	rate	NOUN
bibechana-80853	117	11	of	of	ADP
bibechana-80853	117	12	19.75	19.75	NUM
bibechana-80853	117	13	ml	ml	NOUN
bibechana-80853	117	14	/	/	SYM
bibechana-80853	117	15	min	min	NOUN
bibechana-80853	117	16	/	/	SYM
bibechana-80853	117	17	kg	kg	PROPN
bibechana-80853	117	18	and	and	CCONJ
bibechana-80853	117	19	16.512	16.512	NUM
bibechana-80853	117	20	ml	ml	NOUN
bibechana-80853	117	21	/	/	SYM
bibechana-80853	117	22	min	min	NOUN
bibechana-80853	117	23	/	/	SYM
bibechana-80853	117	24	kg	kg	PROPN
bibechana-80853	117	25	,	,	PUNCT
bibechana-80853	117	26	respectively	respectively	ADV
bibechana-80853	117	27	(	(	PUNCT
bibechana-80853	117	28	supplementary	supplementary	ADJ
bibechana-80853	117	29	table	table	NOUN
bibechana-80853	117	30	2	2	NUM
bibechana-80853	117	31	)	)	PUNCT
bibechana-80853	117	32	.	.	PUNCT
bibechana-80853	118	1	this	this	PRON
bibechana-80853	118	2	indicates	indicate	VERB
bibechana-80853	118	3	that	that	SCONJ
bibechana-80853	118	4	they	they	PRON
bibechana-80853	118	5	are	be	AUX
bibechana-80853	118	6	rapidly	rapidly	ADV
bibechana-80853	118	7	cleared	clear	VERB
bibechana-80853	118	8	from	from	ADP
bibechana-80853	118	9	the	the	DET
bibechana-80853	118	10	body	body	NOUN
bibechana-80853	118	11	,	,	PUNCT
bibechana-80853	118	12	reducing	reduce	VERB
bibechana-80853	118	13	the	the	DET
bibechana-80853	118	14	risk	risk	NOUN
bibechana-80853	118	15	of	of	ADP
bibechana-80853	118	16	accumulation	accumulation	NOUN
bibechana-80853	118	17	and	and	CCONJ
bibechana-80853	118	18	potential	potential	ADJ
bibechana-80853	118	19	toxicity	toxicity	NOUN
bibechana-80853	118	20	.	.	PUNCT
bibechana-80853	119	1	efficient	efficient	ADJ
bibechana-80853	119	2	excretion	excretion	NOUN
bibechana-80853	119	3	minimizes	minimize	VERB
bibechana-80853	119	4	the	the	DET
bibechana-80853	119	5	chances	chance	NOUN
bibechana-80853	119	6	of	of	ADP
bibechana-80853	119	7	toxic	toxic	ADJ
bibechana-80853	119	8	buildup	buildup	NOUN
bibechana-80853	119	9	or	or	CCONJ
bibechana-80853	119	10	prolonged	prolonged	ADJ
bibechana-80853	119	11	exposure	exposure	NOUN
bibechana-80853	119	12	,	,	PUNCT
bibechana-80853	119	13	making	make	VERB
bibechana-80853	119	14	these	these	DET
bibechana-80853	119	15	molecules	molecule	NOUN
bibechana-80853	119	16	less	less	ADV
bibechana-80853	119	17	likely	likely	ADJ
bibechana-80853	119	18	to	to	PART
bibechana-80853	119	19	cause	cause	VERB
bibechana-80853	119	20	long	long	ADJ
bibechana-80853	119	21	-	-	PUNCT
bibechana-80853	119	22	term	term	NOUN
bibechana-80853	119	23	toxicity	toxicity	NOUN
bibechana-80853	119	24	compared	compare	VERB
bibechana-80853	119	25	to	to	ADP
bibechana-80853	119	26	those	those	PRON
bibechana-80853	119	27	with	with	ADP
bibechana-80853	119	28	slower	slow	ADJ
bibechana-80853	119	29	clearance	clearance	NOUN
bibechana-80853	119	30	rates	rate	NOUN
bibechana-80853	119	31	.	.	PUNCT
bibechana-80853	120	1	most	most	ADJ
bibechana-80853	120	2	of	of	ADP
bibechana-80853	120	3	the	the	DET
bibechana-80853	120	4	molecules	molecule	NOUN
bibechana-80853	120	5	(	(	PUNCT
bibechana-80853	120	6	11	11	NUM
bibechana-80853	120	7	)	)	PUNCT
bibechana-80853	120	8	were	be	AUX
bibechana-80853	120	9	classified	classify	VERB
bibechana-80853	120	10	under	under	ADP
bibechana-80853	120	11	class	class	NOUN
bibechana-80853	120	12	4	4	NUM
bibechana-80853	120	13	toxicity	toxicity	NOUN
bibechana-80853	120	14	,	,	PUNCT
bibechana-80853	120	15	indicating	indicate	VERB
bibechana-80853	120	16	they	they	PRON
bibechana-80853	120	17	are	be	AUX
bibechana-80853	120	18	harmful	harmful	ADJ
bibechana-80853	120	19	and	and	CCONJ
bibechana-80853	120	20	can	can	AUX
bibechana-80853	120	21	lead	lead	VERB
bibechana-80853	120	22	to	to	ADP
bibechana-80853	120	23	significant	significant	ADJ
bibechana-80853	120	24	health	health	NOUN
bibechana-80853	120	25	effects	effect	NOUN
bibechana-80853	120	26	at	at	ADP
bibechana-80853	120	27	higher	high	ADJ
bibechana-80853	120	28	doses	dose	NOUN
bibechana-80853	120	29	(	(	PUNCT
bibechana-80853	120	30	890	890	NUM
bibechana-80853	120	31	mg	mg	PROPN
bibechana-80853	120	32	/	/	SYM
bibechana-80853	120	33	kg	kg	PROPN
bibechana-80853	120	34	)	)	PUNCT
bibechana-80853	120	35	.	.	PUNCT
bibechana-80853	121	1	however	however	ADV
bibechana-80853	121	2	,	,	PUNCT
bibechana-80853	121	3	they	they	PRON
bibechana-80853	121	4	are	be	AUX
bibechana-80853	121	5	less	less	ADV
bibechana-80853	121	6	likely	likely	ADJ
bibechana-80853	121	7	to	to	PART
bibechana-80853	121	8	be	be	AUX
bibechana-80853	121	9	fatal	fatal	ADJ
bibechana-80853	121	10	than	than	ADP
bibechana-80853	121	11	classes	class	NOUN
bibechana-80853	121	12	3	3	NUM
bibechana-80853	121	13	,	,	PUNCT
bibechana-80853	121	14	2	2	NUM
bibechana-80853	121	15	,	,	PUNCT
bibechana-80853	121	16	and	and	CCONJ
bibechana-80853	121	17	1	1	NUM
bibechana-80853	121	18	.	.	NOUN
bibechana-80853	121	19	three	three	NUM
bibechana-80853	121	20	molecules	molecule	NOUN
bibechana-80853	121	21	(	(	PUNCT
bibechana-80853	121	22	triacontane	triacontane	NOUN
bibechana-80853	121	23	,	,	PUNCT
bibechana-80853	121	24	hentriacontane	hentriacontane	NOUN
bibechana-80853	121	25	,	,	PUNCT
bibechana-80853	121	26	and	and	CCONJ
bibechana-80853	121	27	bersaldegenin-3acetate	bersaldegenin-3acetate	NOUN
bibechana-80853	121	28	)	)	PUNCT
bibechana-80853	121	29	were	be	AUX
bibechana-80853	121	30	classified	classify	VERB
bibechana-80853	121	31	as	as	ADP
bibechana-80853	121	32	class	class	NOUN
bibechana-80853	121	33	3	3	NUM
bibechana-80853	121	34	,	,	PUNCT
bibechana-80853	121	35	which	which	PRON
bibechana-80853	121	36	are	be	AUX
bibechana-80853	121	37	toxic	toxic	ADJ
bibechana-80853	121	38	at	at	ADP
bibechana-80853	121	39	moderate	moderate	ADJ
bibechana-80853	121	40	doses	dose	NOUN
bibechana-80853	121	41	,	,	PUNCT
bibechana-80853	121	42	while	while	SCONJ
bibechana-80853	121	43	two	two	NUM
bibechana-80853	121	44	were	be	AUX
bibechana-80853	121	45	in	in	ADP
bibechana-80853	121	46	class	class	NOUN
bibechana-80853	121	47	5	5	NUM
bibechana-80853	121	48	,	,	PUNCT
bibechana-80853	121	49	indicating	indicate	VERB
bibechana-80853	121	50	they	they	PRON
bibechana-80853	121	51	are	be	AUX
bibechana-80853	121	52	less	less	ADV
bibechana-80853	121	53	toxic	toxic	ADJ
bibechana-80853	121	54	but	but	CCONJ
bibechana-80853	121	55	still	still	ADV
bibechana-80853	121	56	harmful	harmful	ADJ
bibechana-80853	121	57	at	at	ADP
bibechana-80853	121	58	very	very	ADV
bibechana-80853	121	59	high	high	ADJ
bibechana-80853	121	60	doses	dose	NOUN
bibechana-80853	121	61	.	.	PUNCT
bibechana-80853	122	1	three	three	NUM
bibechana-80853	122	2	molecules	molecule	NOUN
bibechana-80853	122	3	(	(	PUNCT
bibechana-80853	122	4	taraxerol	taraxerol	NOUN
bibechana-80853	122	5	,	,	PUNCT
bibechana-80853	122	6	pseudotaraxasterol	pseudotaraxasterol	NOUN
bibechana-80853	122	7	,	,	PUNCT
bibechana-80853	122	8	and	and	CCONJ
bibechana-80853	122	9	epigallocatechin	epigallocatechin	PROPN
bibechana-80853	122	10	)	)	PUNCT
bibechana-80853	122	11	were	be	AUX
bibechana-80853	122	12	determined	determine	VERB
bibechana-80853	122	13	to	to	PART
bibechana-80853	122	14	have	have	VERB
bibechana-80853	122	15	class	class	NOUN
bibechana-80853	122	16	6	6	NUM
bibechana-80853	122	17	toxicity	toxicity	NOUN
bibechana-80853	122	18	,	,	PUNCT
bibechana-80853	122	19	suggesting	suggest	VERB
bibechana-80853	122	20	they	they	PRON
bibechana-80853	122	21	have	have	VERB
bibechana-80853	122	22	low	low	ADJ
bibechana-80853	122	23	or	or	CCONJ
bibechana-80853	122	24	negligible	negligible	ADJ
bibechana-80853	122	25	toxicity	toxicity	NOUN
bibechana-80853	122	26	and	and	CCONJ
bibechana-80853	122	27	are	be	AUX
bibechana-80853	122	28	generally	generally	ADV
bibechana-80853	122	29	safe	safe	ADJ
bibechana-80853	122	30	at	at	ADP
bibechana-80853	122	31	typical	typical	ADJ
bibechana-80853	122	32	exposure	exposure	NOUN
bibechana-80853	122	33	levels	level	NOUN
bibechana-80853	122	34	(	(	PUNCT
bibechana-80853	122	35	7000	7000	NUM
bibechana-80853	122	36	mg	mg	PROPN
bibechana-80853	122	37	/	/	SYM
bibechana-80853	122	38	kg	kg	PROPN
bibechana-80853	122	39	)	)	PUNCT
bibechana-80853	122	40	.	.	PUNCT
bibechana-80853	123	1	one	one	NUM
bibechana-80853	123	2	molecule	molecule	NOUN
bibechana-80853	123	3	,	,	PUNCT
bibechana-80853	123	4	identified	identify	VERB
bibechana-80853	123	5	as	as	ADP
bibechana-80853	123	6	cardenolides	cardenolide	NOUN
bibechana-80853	123	7	,	,	PUNCT
bibechana-80853	123	8	was	be	AUX
bibechana-80853	123	9	categorized	categorize	VERB
bibechana-80853	123	10	in	in	ADP
bibechana-80853	123	11	class	class	NOUN
bibechana-80853	123	12	2	2	NUM
bibechana-80853	123	13	,	,	PUNCT
bibechana-80853	123	14	indicating	indicate	VERB
bibechana-80853	123	15	high	high	ADJ
bibechana-80853	123	16	toxicity	toxicity	NOUN
bibechana-80853	123	17	with	with	ADP
bibechana-80853	123	18	potentially	potentially	ADV
bibechana-80853	123	19	fatal	fatal	ADJ
bibechana-80853	123	20	effects	effect	NOUN
bibechana-80853	123	21	at	at	ADP
bibechana-80853	123	22	relatively	relatively	ADV
bibechana-80853	123	23	low	low	ADJ
bibechana-80853	123	24	doses	dose	NOUN
bibechana-80853	123	25	(	(	PUNCT
bibechana-80853	123	26	34	34	NUM
bibechana-80853	123	27	mg	mg	PROPN
bibechana-80853	123	28	/	/	SYM
bibechana-80853	123	29	kg	kg	NOUN
bibechana-80853	123	30	)	)	PUNCT
bibechana-80853	123	31	(	(	PUNCT
bibechana-80853	123	32	supplementary	supplementary	ADJ
bibechana-80853	123	33	table	table	NOUN
bibechana-80853	123	34	3	3	NUM
bibechana-80853	123	35	)	)	PUNCT
bibechana-80853	123	36	.	.	PUNCT
bibechana-80853	124	1	this	this	PRON
bibechana-80853	124	2	suggests	suggest	VERB
bibechana-80853	124	3	that	that	SCONJ
bibechana-80853	124	4	even	even	ADV
bibechana-80853	124	5	small	small	ADJ
bibechana-80853	124	6	ram	ram	NOUN
bibechana-80853	124	7	lal	lal	PROPN
bibechana-80853	124	8	(	(	PUNCT
bibechana-80853	124	9	swagat	swagat	ADJ
bibechana-80853	124	10	)	)	PUNCT
bibechana-80853	124	11	shrestha	shrestha	NOUN
bibechana-80853	124	12	et	et	PROPN
bibechana-80853	125	1	al./	al./	ADV
bibechana-80853	125	2	bibechana	bibechana	PROPN
bibechana-80853	125	3	22	22	NUM
bibechana-80853	125	4	(	(	PUNCT
bibechana-80853	125	5	2025	2025	NUM
bibechana-80853	125	6	)	)	PUNCT
bibechana-80853	125	7	291	291	NUM
bibechana-80853	125	8	-	-	SYM
bibechana-80853	125	9	298	298	NUM
bibechana-80853	125	10	296	296	NUM
bibechana-80853	125	11	amounts	amount	NOUN
bibechana-80853	125	12	could	could	AUX
bibechana-80853	125	13	pose	pose	VERB
bibechana-80853	125	14	serious	serious	ADJ
bibechana-80853	125	15	health	health	NOUN
bibechana-80853	125	16	risks	risk	NOUN
bibechana-80853	125	17	,	,	PUNCT
bibechana-80853	125	18	highlighting	highlight	VERB
bibechana-80853	125	19	the	the	DET
bibechana-80853	125	20	need	need	NOUN
bibechana-80853	125	21	for	for	ADP
bibechana-80853	125	22	caution	caution	NOUN
bibechana-80853	125	23	in	in	ADP
bibechana-80853	125	24	handling	handling	NOUN
bibechana-80853	125	25	and	and	CCONJ
bibechana-80853	125	26	potential	potential	ADJ
bibechana-80853	125	27	therapeutic	therapeutic	ADJ
bibechana-80853	125	28	applications	application	NOUN
bibechana-80853	125	29	.	.	PUNCT
bibechana-80853	126	1	for	for	ADP
bibechana-80853	126	2	any	any	DET
bibechana-80853	126	3	practical	practical	ADJ
bibechana-80853	126	4	use	use	NOUN
bibechana-80853	126	5	,	,	PUNCT
bibechana-80853	126	6	such	such	ADJ
bibechana-80853	126	7	as	as	ADP
bibechana-80853	126	8	in	in	ADP
bibechana-80853	126	9	drug	drug	NOUN
bibechana-80853	126	10	development	development	NOUN
bibechana-80853	126	11	or	or	CCONJ
bibechana-80853	126	12	herbal	herbal	ADJ
bibechana-80853	126	13	preparations	preparation	NOUN
bibechana-80853	126	14	,	,	PUNCT
bibechana-80853	126	15	rigorous	rigorous	ADJ
bibechana-80853	126	16	dose	dose	NOUN
bibechana-80853	126	17	optimization	optimization	NOUN
bibechana-80853	126	18	,	,	PUNCT
bibechana-80853	126	19	careful	careful	ADJ
bibechana-80853	126	20	monitoring	monitoring	NOUN
bibechana-80853	126	21	,	,	PUNCT
bibechana-80853	126	22	and	and	CCONJ
bibechana-80853	126	23	safety	safety	NOUN
bibechana-80853	126	24	assessments	assessment	NOUN
bibechana-80853	126	25	would	would	AUX
bibechana-80853	126	26	be	be	AUX
bibechana-80853	126	27	essential	essential	ADJ
bibechana-80853	126	28	to	to	PART
bibechana-80853	126	29	prevent	prevent	VERB
bibechana-80853	126	30	toxic	toxic	ADJ
bibechana-80853	126	31	effects	effect	NOUN
bibechana-80853	126	32	.	.	PUNCT
bibechana-80853	127	1	additionally	additionally	ADV
bibechana-80853	127	2	,	,	PUNCT
bibechana-80853	127	3	formulation	formulation	NOUN
bibechana-80853	127	4	strategies	strategy	NOUN
bibechana-80853	127	5	or	or	CCONJ
bibechana-80853	127	6	structural	structural	ADJ
bibechana-80853	127	7	modifications	modification	NOUN
bibechana-80853	127	8	may	may	AUX
bibechana-80853	127	9	be	be	AUX
bibechana-80853	127	10	required	require	VERB
bibechana-80853	127	11	to	to	PART
bibechana-80853	127	12	mitigate	mitigate	VERB
bibechana-80853	127	13	toxicity	toxicity	NOUN
bibechana-80853	127	14	while	while	SCONJ
bibechana-80853	127	15	preserving	preserve	VERB
bibechana-80853	127	16	any	any	DET
bibechana-80853	127	17	beneficial	beneficial	ADJ
bibechana-80853	127	18	biological	biological	ADJ
bibechana-80853	127	19	activity	activity	NOUN
bibechana-80853	127	20	.	.	PUNCT
bibechana-80853	128	1	astragalin	astragalin	ADJ
bibechana-80853	128	2	,	,	PUNCT
bibechana-80853	128	3	although	although	SCONJ
bibechana-80853	128	4	inactive	inactive	ADJ
bibechana-80853	128	5	across	across	ADP
bibechana-80853	128	6	specific	specific	ADJ
bibechana-80853	128	7	toxicity	toxicity	NOUN
bibechana-80853	128	8	endpoints	endpoint	NOUN
bibechana-80853	128	9	such	such	ADJ
bibechana-80853	128	10	as	as	ADP
bibechana-80853	128	11	carcinogenicity	carcinogenicity	NOUN
bibechana-80853	128	12	,	,	PUNCT
bibechana-80853	128	13	immunotoxicity	immunotoxicity	NOUN
bibechana-80853	128	14	,	,	PUNCT
bibechana-80853	128	15	mutagenicity	mutagenicity	NOUN
bibechana-80853	128	16	,	,	PUNCT
bibechana-80853	128	17	and	and	CCONJ
bibechana-80853	128	18	cytotoxicity	cytotoxicity	NOUN
bibechana-80853	128	19	,	,	PUNCT
bibechana-80853	128	20	was	be	AUX
bibechana-80853	128	21	classified	classify	VERB
bibechana-80853	128	22	in	in	ADP
bibechana-80853	128	23	a	a	DET
bibechana-80853	128	24	safe	safe	ADJ
bibechana-80853	128	25	toxicity	toxicity	NOUN
bibechana-80853	128	26	class	class	NOUN
bibechana-80853	128	27	(	(	PUNCT
bibechana-80853	128	28	class	class	NOUN
bibechana-80853	128	29	5	5	NUM
bibechana-80853	128	30	)	)	PUNCT
bibechana-80853	128	31	.	.	PUNCT
bibechana-80853	129	1	it	it	PRON
bibechana-80853	129	2	demonstrated	demonstrate	VERB
bibechana-80853	129	3	favorable	favorable	ADJ
bibechana-80853	129	4	outcomes	outcome	NOUN
bibechana-80853	129	5	in	in	ADP
bibechana-80853	129	6	molecular	molecular	ADJ
bibechana-80853	129	7	docking	docking	NOUN
bibechana-80853	129	8	studies	study	NOUN
bibechana-80853	129	9	,	,	PUNCT
bibechana-80853	129	10	justifying	justify	VERB
bibechana-80853	129	11	further	further	ADJ
bibechana-80853	129	12	exploration	exploration	NOUN
bibechana-80853	129	13	.	.	PUNCT
bibechana-80853	130	1	note	note	NOUN
bibechana-80853	130	2	:	:	PUNCT
bibechana-80853	130	3	water	water	NOUN
bibechana-80853	130	4	solubility	solubility	NOUN
bibechana-80853	130	5	is	be	AUX
bibechana-80853	130	6	indicated	indicate	VERB
bibechana-80853	130	7	as	as	ADP
bibechana-80853	130	8	:	:	PUNCT
bibechana-80853	130	9	insoluble	insoluble	ADJ
bibechana-80853	130	10	(	(	PUNCT
bibechana-80853	130	11	-	-	PUNCT
bibechana-80853	130	12	)	)	PUNCT
bibechana-80853	130	13	,	,	PUNCT
bibechana-80853	130	14	poorly	poorly	ADV
bibechana-80853	130	15	soluble	soluble	ADJ
bibechana-80853	130	16	(	(	PUNCT
bibechana-80853	130	17	+	+	NOUN
bibechana-80853	130	18	)	)	PUNCT
bibechana-80853	130	19	,	,	PUNCT
bibechana-80853	130	20	moderately	moderately	ADV
bibechana-80853	130	21	soluble	soluble	ADJ
bibechana-80853	130	22	(	(	PUNCT
bibechana-80853	130	23	+	+	NOUN
bibechana-80853	130	24	+	+	NOUN
bibechana-80853	130	25	)	)	PUNCT
bibechana-80853	130	26	,	,	PUNCT
bibechana-80853	130	27	and	and	CCONJ
bibechana-80853	130	28	highly	highly	ADV
bibechana-80853	130	29	soluble	soluble	ADJ
bibechana-80853	130	30	(	(	PUNCT
bibechana-80853	130	31	+	+	ADJ
bibechana-80853	130	32	+	+	NOUN
bibechana-80853	130	33	+	+	NOUN
bibechana-80853	130	34	)	)	PUNCT
bibechana-80853	130	35	.	.	PUNCT
bibechana-80853	131	1	and	and	CCONJ
bibechana-80853	131	2	rejection	rejection	NOUN
bibechana-80853	131	3	in	in	ADP
bibechana-80853	131	4	the	the	DET
bibechana-80853	131	5	table	table	NOUN
bibechana-80853	131	6	indicates	indicate	VERB
bibechana-80853	131	7	the	the	DET
bibechana-80853	131	8	violation	violation	NOUN
bibechana-80853	131	9	of	of	ADP
bibechana-80853	131	10	2	2	NUM
bibechana-80853	131	11	rules	rule	NOUN
bibechana-80853	131	12	of	of	ADP
bibechana-80853	131	13	lipinki	lipinki	NOUN
bibechana-80853	131	14	.	.	PUNCT
bibechana-80853	132	1	the	the	DET
bibechana-80853	132	2	admet	admet	PROPN
bibechana-80853	132	3	properties	property	NOUN
bibechana-80853	132	4	of	of	ADP
bibechana-80853	132	5	several	several	ADJ
bibechana-80853	132	6	reference	reference	NOUN
bibechana-80853	132	7	drugs	drug	NOUN
bibechana-80853	132	8	(	(	PUNCT
bibechana-80853	132	9	enalapril	enalapril	PROPN
bibechana-80853	132	10	,	,	PUNCT
bibechana-80853	132	11	metoprolol	metoprolol	PROPN
bibechana-80853	132	12	,	,	PUNCT
bibechana-80853	132	13	ramipril	ramipril	NOUN
bibechana-80853	132	14	,	,	PUNCT
bibechana-80853	132	15	and	and	CCONJ
bibechana-80853	132	16	digoxin	digoxin	NOUN
bibechana-80853	132	17	)	)	PUNCT
bibechana-80853	132	18	commonly	commonly	ADV
bibechana-80853	132	19	used	use	VERB
bibechana-80853	132	20	in	in	ADP
bibechana-80853	132	21	the	the	DET
bibechana-80853	132	22	management	management	NOUN
bibechana-80853	132	23	of	of	ADP
bibechana-80853	132	24	cv	cv	PROPN
bibechana-80853	132	25	diseases	disease	NOUN
bibechana-80853	132	26	are	be	AUX
bibechana-80853	132	27	shown	show	VERB
bibechana-80853	132	28	in	in	ADP
bibechana-80853	132	29	supplementary	supplementary	ADJ
bibechana-80853	132	30	table	table	NOUN
bibechana-80853	132	31	4	4	NUM
bibechana-80853	132	32	.	.	PUNCT
bibechana-80853	132	33	with	with	ADP
bibechana-80853	132	34	the	the	DET
bibechana-80853	132	35	highest	high	ADJ
bibechana-80853	132	36	tpsa	tpsa	NOUN
bibechana-80853	132	37	(	(	PUNCT
bibechana-80853	132	38	203.06	203.06	NUM
bibechana-80853	132	39	å²	å²	NOUN
bibechana-80853	132	40	)	)	PUNCT
bibechana-80853	132	41	,	,	PUNCT
bibechana-80853	132	42	digoxin	digoxin	PROPN
bibechana-80853	132	43	may	may	AUX
bibechana-80853	132	44	struggle	struggle	VERB
bibechana-80853	132	45	to	to	PART
bibechana-80853	132	46	cross	cross	VERB
bibechana-80853	132	47	cell	cell	NOUN
bibechana-80853	132	48	membranes	membrane	NOUN
bibechana-80853	132	49	,	,	PUNCT
bibechana-80853	132	50	leading	lead	VERB
bibechana-80853	132	51	to	to	ADP
bibechana-80853	132	52	its	its	PRON
bibechana-80853	132	53	lower	low	ADJ
bibechana-80853	132	54	gi	gi	NOUN
bibechana-80853	132	55	absorption	absorption	NOUN
bibechana-80853	132	56	and	and	CCONJ
bibechana-80853	132	57	poor	poor	ADJ
bibechana-80853	132	58	bbb	bbb	NOUN
bibechana-80853	132	59	permeability	permeability	NOUN
bibechana-80853	132	60	.	.	PUNCT
bibechana-80853	133	1	all	all	DET
bibechana-80853	133	2	the	the	DET
bibechana-80853	133	3	drugs	drug	NOUN
bibechana-80853	133	4	,	,	PUNCT
bibechana-80853	133	5	except	except	SCONJ
bibechana-80853	133	6	digoxin	digoxin	PROPN
bibechana-80853	133	7	,	,	PUNCT
bibechana-80853	133	8	showed	show	VERB
bibechana-80853	133	9	high	high	ADJ
bibechana-80853	133	10	gi	gi	NOUN
bibechana-80853	133	11	absorption	absorption	NOUN
bibechana-80853	133	12	,	,	PUNCT
bibechana-80853	133	13	suggesting	suggest	VERB
bibechana-80853	133	14	they	they	PRON
bibechana-80853	133	15	are	be	AUX
bibechana-80853	133	16	effectively	effectively	ADV
bibechana-80853	133	17	absorbed	absorb	VERB
bibechana-80853	133	18	orally	orally	ADV
bibechana-80853	133	19	.	.	PUNCT
bibechana-80853	134	1	despite	despite	SCONJ
bibechana-80853	134	2	digoxin	digoxin	NOUN
bibechana-80853	134	3	being	be	AUX
bibechana-80853	134	4	classified	classify	VERB
bibechana-80853	134	5	as	as	ADP
bibechana-80853	134	6	class	class	NOUN
bibechana-80853	134	7	1	1	NUM
bibechana-80853	134	8	in	in	ADP
bibechana-80853	134	9	toxicity	toxicity	NOUN
bibechana-80853	134	10	,	,	PUNCT
bibechana-80853	134	11	it	it	PRON
bibechana-80853	134	12	is	be	AUX
bibechana-80853	134	13	still	still	ADV
bibechana-80853	134	14	used	use	VERB
bibechana-80853	134	15	for	for	ADP
bibechana-80853	134	16	the	the	DET
bibechana-80853	134	17	intervention	intervention	NOUN
bibechana-80853	134	18	of	of	ADP
bibechana-80853	134	19	cv	cv	PROPN
bibechana-80853	134	20	diseases	disease	NOUN
bibechana-80853	134	21	.	.	PUNCT
bibechana-80853	135	1	the	the	DET
bibechana-80853	135	2	ligand	ligand	NOUN
bibechana-80853	135	3	we	we	PRON
bibechana-80853	135	4	studied	study	VERB
bibechana-80853	135	5	,	,	PUNCT
bibechana-80853	135	6	astragalin	astragalin	ADV
bibechana-80853	135	7	,	,	PUNCT
bibechana-80853	135	8	is	be	AUX
bibechana-80853	135	9	classified	classify	VERB
bibechana-80853	135	10	as	as	ADP
bibechana-80853	135	11	class	class	NOUN
bibechana-80853	135	12	5	5	NUM
bibechana-80853	135	13	in	in	ADP
bibechana-80853	135	14	toxicity	toxicity	NOUN
bibechana-80853	135	15	and	and	CCONJ
bibechana-80853	135	16	has	have	VERB
bibechana-80853	135	17	good	good	ADJ
bibechana-80853	135	18	solubility	solubility	NOUN
bibechana-80853	135	19	and	and	CCONJ
bibechana-80853	135	20	bbb	bbb	NOUN
bibechana-80853	135	21	permeability	permeability	NOUN
bibechana-80853	135	22	.	.	PUNCT
bibechana-80853	136	1	the	the	DET
bibechana-80853	136	2	phytochemicals	phytochemical	NOUN
bibechana-80853	136	3	astragalin	astragalin	ADV
bibechana-80853	136	4	and	and	CCONJ
bibechana-80853	136	5	patuletin	patuletin	NOUN
bibechana-80853	136	6	from	from	ADP
bibechana-80853	136	7	k.	k.	PROPN
bibechana-80853	136	8	pinnata	pinnata	PROPN
bibechana-80853	136	9	demonstrated	demonstrate	VERB
bibechana-80853	136	10	significant	significant	ADJ
bibechana-80853	136	11	binding	bind	VERB
bibechana-80853	136	12	affinity	affinity	NOUN
bibechana-80853	136	13	to	to	ADP
bibechana-80853	136	14	the	the	DET
bibechana-80853	136	15	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	136	16	receptor	receptor	NOUN
bibechana-80853	136	17	in	in	ADP
bibechana-80853	136	18	molecular	molecular	ADJ
bibechana-80853	136	19	docking	docking	NOUN
bibechana-80853	136	20	studies	study	NOUN
bibechana-80853	136	21	,	,	PUNCT
bibechana-80853	136	22	suggesting	suggest	VERB
bibechana-80853	136	23	their	their	PRON
bibechana-80853	136	24	potential	potential	NOUN
bibechana-80853	136	25	as	as	ADP
bibechana-80853	136	26	modulators	modulator	NOUN
bibechana-80853	136	27	.	.	PUNCT
bibechana-80853	137	1	furthermore	furthermore	ADV
bibechana-80853	137	2	,	,	PUNCT
bibechana-80853	137	3	their	their	PRON
bibechana-80853	137	4	admet	admet	NOUN
bibechana-80853	137	5	profiles	profile	NOUN
bibechana-80853	137	6	indicate	indicate	VERB
bibechana-80853	137	7	favorable	favorable	ADJ
bibechana-80853	137	8	solubility	solubility	NOUN
bibechana-80853	137	9	,	,	PUNCT
bibechana-80853	137	10	good	good	ADJ
bibechana-80853	137	11	gi	gi	NOUN
bibechana-80853	137	12	absorption	absorption	NOUN
bibechana-80853	137	13	,	,	PUNCT
bibechana-80853	137	14	and	and	CCONJ
bibechana-80853	137	15	bbb	bbb	NOUN
bibechana-80853	137	16	permeability	permeability	NOUN
bibechana-80853	137	17	,	,	PUNCT
bibechana-80853	137	18	along	along	ADP
bibechana-80853	137	19	with	with	ADP
bibechana-80853	137	20	lower	low	ADJ
bibechana-80853	137	21	toxicity	toxicity	NOUN
bibechana-80853	137	22	levels	level	NOUN
bibechana-80853	137	23	,	,	PUNCT
bibechana-80853	137	24	making	make	VERB
bibechana-80853	137	25	them	they	PRON
bibechana-80853	137	26	promising	promise	VERB
bibechana-80853	137	27	candidates	candidate	NOUN
bibechana-80853	137	28	for	for	ADP
bibechana-80853	137	29	cv	cv	PROPN
bibechana-80853	137	30	drug	drug	NOUN
bibechana-80853	137	31	development	development	NOUN
bibechana-80853	137	32	.	.	PUNCT
bibechana-80853	138	1	4	4	NUM
bibechana-80853	138	2	conclusion	conclusion	NOUN
bibechana-80853	138	3	the	the	DET
bibechana-80853	138	4	results	result	NOUN
bibechana-80853	138	5	of	of	ADP
bibechana-80853	138	6	this	this	DET
bibechana-80853	138	7	study	study	NOUN
bibechana-80853	138	8	underscore	underscore	VERB
bibechana-80853	138	9	the	the	DET
bibechana-80853	138	10	potential	potential	NOUN
bibechana-80853	138	11	of	of	ADP
bibechana-80853	138	12	kalanchoe	kalanchoe	NOUN
bibechana-80853	138	13	pinnata	pinnata	NOUN
bibechana-80853	138	14	phytochemicals	phytochemical	NOUN
bibechana-80853	138	15	as	as	ADP
bibechana-80853	138	16	modulators	modulator	NOUN
bibechana-80853	138	17	of	of	ADP
bibechana-80853	138	18	the	the	DET
bibechana-80853	138	19	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	138	20	receptor	receptor	NOUN
bibechana-80853	138	21	,	,	PUNCT
bibechana-80853	138	22	with	with	ADP
bibechana-80853	138	23	significant	significant	ADJ
bibechana-80853	138	24	implications	implication	NOUN
bibechana-80853	138	25	for	for	ADP
bibechana-80853	138	26	cv	cv	PROPN
bibechana-80853	138	27	disease	disease	NOUN
bibechana-80853	138	28	management	management	NOUN
bibechana-80853	138	29	.	.	PUNCT
bibechana-80853	139	1	the	the	DET
bibechana-80853	139	2	molecular	molecular	ADJ
bibechana-80853	139	3	docking	docking	NOUN
bibechana-80853	139	4	analysis	analysis	NOUN
bibechana-80853	139	5	revealed	reveal	VERB
bibechana-80853	139	6	that	that	SCONJ
bibechana-80853	139	7	the	the	DET
bibechana-80853	139	8	phytochemical	phytochemical	ADJ
bibechana-80853	139	9	astragalin	astragalin	NOUN
bibechana-80853	139	10	exhibited	exhibit	VERB
bibechana-80853	139	11	strong	strong	ADJ
bibechana-80853	139	12	binding	bind	VERB
bibechana-80853	139	13	affinities	affinity	NOUN
bibechana-80853	139	14	close	close	ADV
bibechana-80853	139	15	to	to	ADP
bibechana-80853	139	16	the	the	DET
bibechana-80853	139	17	native	native	ADJ
bibechana-80853	139	18	ligand	ligand	NOUN
bibechana-80853	139	19	,	,	PUNCT
bibechana-80853	139	20	suggesting	suggest	VERB
bibechana-80853	139	21	its	its	PRON
bibechana-80853	139	22	potential	potential	ADJ
bibechana-80853	139	23	effectiveness	effectiveness	NOUN
bibechana-80853	139	24	in	in	ADP
bibechana-80853	139	25	modulating	modulate	VERB
bibechana-80853	139	26	mr	mr	ADJ
bibechana-80853	139	27	activity	activity	NOUN
bibechana-80853	139	28	.	.	PUNCT
bibechana-80853	140	1	furthermore	furthermore	ADV
bibechana-80853	140	2	,	,	PUNCT
bibechana-80853	140	3	the	the	DET
bibechana-80853	140	4	admet	admet	NOUN
bibechana-80853	140	5	analysis	analysis	NOUN
bibechana-80853	140	6	indicated	indicate	VERB
bibechana-80853	140	7	that	that	SCONJ
bibechana-80853	140	8	most	most	ADJ
bibechana-80853	140	9	of	of	ADP
bibechana-80853	140	10	the	the	DET
bibechana-80853	140	11	studied	study	VERB
bibechana-80853	140	12	compounds	compound	NOUN
bibechana-80853	140	13	demonstrated	demonstrate	VERB
bibechana-80853	140	14	favorable	favorable	ADJ
bibechana-80853	140	15	pharmacokinetic	pharmacokinetic	ADJ
bibechana-80853	140	16	properties	property	NOUN
bibechana-80853	140	17	,	,	PUNCT
bibechana-80853	140	18	including	include	VERB
bibechana-80853	140	19	good	good	ADJ
bibechana-80853	140	20	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	140	21	absorption	absorption	NOUN
bibechana-80853	140	22	,	,	PUNCT
bibechana-80853	140	23	toxicity	toxicity	NOUN
bibechana-80853	140	24	endpoints	endpoint	NOUN
bibechana-80853	140	25	,	,	PUNCT
bibechana-80853	140	26	and	and	CCONJ
bibechana-80853	140	27	acceptable	acceptable	ADJ
bibechana-80853	140	28	toxicity	toxicity	NOUN
bibechana-80853	140	29	levels	level	NOUN
bibechana-80853	140	30	,	,	PUNCT
bibechana-80853	140	31	with	with	ADP
bibechana-80853	140	32	several	several	ADJ
bibechana-80853	140	33	compounds	compound	NOUN
bibechana-80853	140	34	falling	fall	VERB
bibechana-80853	140	35	within	within	ADP
bibechana-80853	140	36	safe	safe	ADJ
bibechana-80853	140	37	toxicity	toxicity	NOUN
bibechana-80853	140	38	classes	class	NOUN
bibechana-80853	140	39	.	.	PUNCT
bibechana-80853	141	1	notably	notably	ADV
bibechana-80853	141	2	,	,	PUNCT
bibechana-80853	141	3	astragalin	astragalin	PROPN
bibechana-80853	141	4	stands	stand	VERB
bibechana-80853	141	5	as	as	ADP
bibechana-80853	141	6	a	a	DET
bibechana-80853	141	7	particularly	particularly	ADV
bibechana-80853	141	8	promising	promising	ADJ
bibechana-80853	141	9	candidate	candidate	NOUN
bibechana-80853	141	10	,	,	PUNCT
bibechana-80853	141	11	exhibiting	exhibit	VERB
bibechana-80853	141	12	a	a	DET
bibechana-80853	141	13	strong	strong	ADJ
bibechana-80853	141	14	binding	bind	VERB
bibechana-80853	141	15	affinity	affinity	NOUN
bibechana-80853	141	16	and	and	CCONJ
bibechana-80853	141	17	low	low	ADJ
bibechana-80853	141	18	toxicity	toxicity	NOUN
bibechana-80853	141	19	,	,	PUNCT
bibechana-80853	141	20	making	make	VERB
bibechana-80853	141	21	it	it	PRON
bibechana-80853	141	22	a	a	DET
bibechana-80853	141	23	viable	viable	ADJ
bibechana-80853	141	24	candidate	candidate	NOUN
bibechana-80853	141	25	for	for	ADP
bibechana-80853	141	26	further	further	ADJ
bibechana-80853	141	27	investigation	investigation	NOUN
bibechana-80853	141	28	.	.	PUNCT
bibechana-80853	142	1	these	these	DET
bibechana-80853	142	2	findings	finding	NOUN
bibechana-80853	142	3	provide	provide	VERB
bibechana-80853	142	4	a	a	DET
bibechana-80853	142	5	formidable	formidable	ADJ
bibechana-80853	142	6	foundation	foundation	NOUN
bibechana-80853	142	7	for	for	ADP
bibechana-80853	142	8	in	in	ADP
bibechana-80853	142	9	vitro	vitro	X
bibechana-80853	142	10	and	and	CCONJ
bibechana-80853	142	11	in	in	ADP
bibechana-80853	142	12	vivo	vivo	ADJ
bibechana-80853	142	13	studies	study	NOUN
bibechana-80853	142	14	to	to	PART
bibechana-80853	142	15	explore	explore	VERB
bibechana-80853	142	16	the	the	DET
bibechana-80853	142	17	possibilities	possibility	NOUN
bibechana-80853	142	18	of	of	ADP
bibechana-80853	142	19	the	the	DET
bibechana-80853	142	20	therapeutic	therapeutic	ADJ
bibechana-80853	142	21	potential	potential	NOUN
bibechana-80853	142	22	of	of	ADP
bibechana-80853	142	23	k.	k.	PROPN
bibechana-80853	142	24	pinnata	pinnata	NOUN
bibechana-80853	142	25	phytochemicals	phytochemical	NOUN
bibechana-80853	142	26	in	in	ADP
bibechana-80853	142	27	cv	cv	PROPN
bibechana-80853	142	28	disease	disease	NOUN
bibechana-80853	142	29	management	management	NOUN
bibechana-80853	142	30	.	.	PUNCT
bibechana-80853	143	1	ethical	ethical	ADJ
bibechana-80853	143	2	approval	approval	NOUN
bibechana-80853	143	3	the	the	DET
bibechana-80853	143	4	research	research	NOUN
bibechana-80853	143	5	conducted	conduct	VERB
bibechana-80853	143	6	is	be	AUX
bibechana-80853	143	7	not	not	PART
bibechana-80853	143	8	related	relate	VERB
bibechana-80853	143	9	to	to	ADP
bibechana-80853	143	10	either	either	CCONJ
bibechana-80853	143	11	human	human	ADJ
bibechana-80853	143	12	or	or	CCONJ
bibechana-80853	143	13	animal	animal	NOUN
bibechana-80853	143	14	use	use	NOUN
bibechana-80853	143	15	.	.	PUNCT
bibechana-80853	144	1	conflict	conflict	NOUN
bibechana-80853	144	2	of	of	ADP
bibechana-80853	144	3	interest	interest	NOUN
bibechana-80853	144	4	the	the	DET
bibechana-80853	144	5	authors	author	NOUN
bibechana-80853	144	6	declare	declare	VERB
bibechana-80853	144	7	no	no	DET
bibechana-80853	144	8	conflict	conflict	NOUN
bibechana-80853	144	9	of	of	ADP
bibechana-80853	144	10	interest	interest	NOUN
bibechana-80853	144	11	.	.	PUNCT
bibechana-80853	145	1	references	reference	NOUN
bibechana-80853	145	2	[	[	X
bibechana-80853	145	3	1	1	NUM
bibechana-80853	145	4	]	]	X
bibechana-80853	145	5	o.	o.	PROPN
bibechana-80853	145	6	gaidai	gaidai	PROPN
bibechana-80853	145	7	,	,	PUNCT
bibechana-80853	145	8	y.	y.	PROPN
bibechana-80853	145	9	cao	cao	PROPN
bibechana-80853	145	10	,	,	PUNCT
bibechana-80853	145	11	and	and	CCONJ
bibechana-80853	145	12	s.	s.	PROPN
bibechana-80853	145	13	loginov	loginov	PROPN
bibechana-80853	145	14	.	.	PUNCT
bibechana-80853	146	1	global	global	ADJ
bibechana-80853	146	2	cardiovascular	cardiovascular	ADJ
bibechana-80853	146	3	diseases	disease	NOUN
bibechana-80853	146	4	death	death	NOUN
bibechana-80853	146	5	rate	rate	NOUN
bibechana-80853	146	6	prediction	prediction	NOUN
bibechana-80853	146	7	.	.	PUNCT
bibechana-80853	147	1	current	current	ADJ
bibechana-80853	147	2	problems	problem	NOUN
bibechana-80853	147	3	in	in	ADP
bibechana-80853	147	4	cardiology	cardiology	NOUN
bibechana-80853	147	5	,	,	PUNCT
bibechana-80853	147	6	48(5):101622	48(5):101622	NUM
bibechana-80853	147	7	,	,	PUNCT
bibechana-80853	147	8	may	may	AUX
bibechana-80853	147	9	2023	2023	NUM
bibechana-80853	147	10	.	.	PUNCT
bibechana-80853	148	1	[	[	X
bibechana-80853	148	2	2	2	X
bibechana-80853	148	3	]	]	PUNCT
bibechana-80853	148	4	s.	s.	PROPN
bibechana-80853	148	5	bhattarai	bhattarai	PROPN
bibechana-80853	148	6	et	et	PROPN
bibechana-80853	148	7	al	al	PROPN
bibechana-80853	148	8	.	.	PUNCT
bibechana-80853	149	1	cardiovascular	cardiovascular	ADJ
bibechana-80853	149	2	disease	disease	NOUN
bibechana-80853	149	3	trends	trend	NOUN
bibechana-80853	149	4	in	in	ADP
bibechana-80853	149	5	nepal	nepal	ADJ
bibechana-80853	149	6	–	–	PUNCT
bibechana-80853	149	7	an	an	DET
bibechana-80853	149	8	analysis	analysis	NOUN
bibechana-80853	149	9	of	of	ADP
bibechana-80853	149	10	global	global	ADJ
bibechana-80853	149	11	burden	burden	NOUN
bibechana-80853	149	12	of	of	ADP
bibechana-80853	149	13	disease	disease	NOUN
bibechana-80853	149	14	data	datum	NOUN
bibechana-80853	149	15	2017	2017	NUM
bibechana-80853	149	16	.	.	PUNCT
bibechana-80853	150	1	ijc	ijc	PROPN
bibechana-80853	150	2	heart	heart	NOUN
bibechana-80853	150	3	&	&	CCONJ
bibechana-80853	150	4	vasculature	vasculature	NOUN
bibechana-80853	150	5	,	,	PUNCT
bibechana-80853	150	6	30:100602	30:100602	NUM
bibechana-80853	150	7	,	,	PUNCT
bibechana-80853	150	8	october	october	PROPN
bibechana-80853	150	9	2020	2020	NUM
bibechana-80853	150	10	.	.	PUNCT
bibechana-80853	151	1	[	[	X
bibechana-80853	151	2	3	3	X
bibechana-80853	151	3	]	]	X
bibechana-80853	151	4	b.	b.	PROPN
bibechana-80853	151	5	huang	huang	PROPN
bibechana-80853	151	6	,	,	PUNCT
bibechana-80853	151	7	c.	c.	PROPN
bibechana-80853	151	8	huang	huang	PROPN
bibechana-80853	151	9	,	,	PUNCT
bibechana-80853	151	10	l.	l.	PROPN
bibechana-80853	151	11	zhu	zhu	PROPN
bibechana-80853	151	12	,	,	PUNCT
bibechana-80853	151	13	l.	l.	PROPN
bibechana-80853	151	14	xie	xie	PROPN
bibechana-80853	151	15	,	,	PUNCT
bibechana-80853	151	16	y.	y.	PROPN
bibechana-80853	151	17	wang	wang	PROPN
bibechana-80853	151	18	,	,	PUNCT
bibechana-80853	151	19	and	and	CCONJ
bibechana-80853	151	20	n.	n.	PROPN
bibechana-80853	151	21	zhu	zhu	PROPN
bibechana-80853	151	22	.	.	PUNCT
bibechana-80853	152	1	exploring	explore	VERB
bibechana-80853	152	2	the	the	DET
bibechana-80853	152	3	pharmacological	pharmacological	ADJ
bibechana-80853	152	4	mechanisms	mechanism	NOUN
bibechana-80853	152	5	of	of	ADP
bibechana-80853	152	6	tripterygium	tripterygium	NOUN
bibechana-80853	152	7	wilfordii	wilfordii	NOUN
bibechana-80853	152	8	hook	hook	NOUN
bibechana-80853	152	9	f	f	NOUN
bibechana-80853	152	10	against	against	ADP
bibechana-80853	152	11	cardiovascular	cardiovascular	ADJ
bibechana-80853	152	12	disease	disease	NOUN
bibechana-80853	152	13	using	use	VERB
bibechana-80853	152	14	network	network	NOUN
bibechana-80853	152	15	pharmacology	pharmacology	NOUN
bibechana-80853	152	16	and	and	CCONJ
bibechana-80853	152	17	molecular	molecular	ADJ
bibechana-80853	152	18	docking	docking	NOUN
bibechana-80853	152	19	.	.	PUNCT
bibechana-80853	153	1	biomed	biome	VERB
bibechana-80853	153	2	research	research	NOUN
bibechana-80853	153	3	international	international	PROPN
bibechana-80853	153	4	,	,	PUNCT
bibechana-80853	153	5	2021:1–11	2021:1–11	NUM
bibechana-80853	153	6	,	,	PUNCT
bibechana-80853	153	7	august	august	PROPN
bibechana-80853	153	8	2021	2021	NUM
bibechana-80853	153	9	.	.	PUNCT
bibechana-80853	154	1	[	[	X
bibechana-80853	154	2	4	4	X
bibechana-80853	154	3	]	]	X
bibechana-80853	154	4	g.	g.	PROPN
bibechana-80853	154	5	m.	m.	PROPN
bibechana-80853	154	6	kuster	kuster	PROPN
bibechana-80853	154	7	et	et	PROPN
bibechana-80853	154	8	al	al	PROPN
bibechana-80853	154	9	.	.	PUNCT
bibechana-80853	155	1	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	155	2	receptor	receptor	NOUN
bibechana-80853	155	3	inhibition	inhibition	NOUN
bibechana-80853	155	4	ameliorates	ameliorate	VERB
bibechana-80853	155	5	the	the	DET
bibechana-80853	155	6	transition	transition	NOUN
bibechana-80853	155	7	to	to	ADP
bibechana-80853	155	8	myocardial	myocardial	ADJ
bibechana-80853	155	9	failure	failure	NOUN
bibechana-80853	155	10	and	and	CCONJ
bibechana-80853	155	11	decreases	decrease	VERB
bibechana-80853	155	12	oxidative	oxidative	ADJ
bibechana-80853	155	13	stress	stress	NOUN
bibechana-80853	155	14	and	and	CCONJ
bibechana-80853	155	15	inflammation	inflammation	NOUN
bibechana-80853	155	16	in	in	ADP
bibechana-80853	155	17	mice	mouse	NOUN
bibechana-80853	155	18	with	with	ADP
bibechana-80853	155	19	chronic	chronic	ADJ
bibechana-80853	155	20	pressure	pressure	NOUN
bibechana-80853	155	21	overload	overload	NOUN
bibechana-80853	155	22	.	.	PUNCT
bibechana-80853	156	1	circulation	circulation	NOUN
bibechana-80853	156	2	,	,	PUNCT
bibechana-80853	156	3	111(4):420–427	111(4):420–427	NUM
bibechana-80853	156	4	,	,	PUNCT
bibechana-80853	156	5	2005	2005	NUM
bibechana-80853	156	6	.	.	PUNCT
bibechana-80853	157	1	[	[	X
bibechana-80853	157	2	5	5	NUM
bibechana-80853	157	3	]	]	PUNCT
bibechana-80853	157	4	m.	m.	NOUN
bibechana-80853	157	5	buonafine	buonafine	PROPN
bibechana-80853	157	6	,	,	PUNCT
bibechana-80853	157	7	b.	b.	PROPN
bibechana-80853	157	8	bonnard	bonnard	PROPN
bibechana-80853	157	9	,	,	PUNCT
bibechana-80853	157	10	and	and	CCONJ
bibechana-80853	157	11	f.	f.	PROPN
bibechana-80853	157	12	jaisser	jaisser	PROPN
bibechana-80853	157	13	.	.	PUNCT
bibechana-80853	158	1	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	158	2	receptor	receptor	NOUN
bibechana-80853	158	3	and	and	CCONJ
bibechana-80853	158	4	cardiovascular	cardiovascular	ADJ
bibechana-80853	158	5	disease	disease	NOUN
bibechana-80853	158	6	.	.	PUNCT
bibechana-80853	159	1	american	american	PROPN
bibechana-80853	159	2	journal	journal	PROPN
bibechana-80853	159	3	of	of	ADP
bibechana-80853	159	4	hypertension	hypertension	NOUN
bibechana-80853	159	5	,	,	PUNCT
bibechana-80853	159	6	31(11):1165–1174	31(11):1165–1174	PROPN
bibechana-80853	159	7	,	,	PUNCT
bibechana-80853	159	8	2018	2018	NUM
bibechana-80853	159	9	.	.	PUNCT
bibechana-80853	160	1	[	[	X
bibechana-80853	160	2	6	6	NUM
bibechana-80853	160	3	]	]	PUNCT
bibechana-80853	160	4	a.	a.	NOUN
bibechana-80853	160	5	w.	w.	PROPN
bibechana-80853	160	6	krug	krug	PROPN
bibechana-80853	160	7	et	et	PROPN
bibechana-80853	161	1	al	al	PROPN
bibechana-80853	161	2	.	.	PROPN
bibechana-80853	161	3	elevated	elevated	ADJ
bibechana-80853	161	4	mineralocorticoid	mineralocorticoid	NOUN
bibechana-80853	161	5	receptor	receptor	NOUN
bibechana-80853	161	6	activity	activity	NOUN
bibechana-80853	161	7	in	in	ADP
bibechana-80853	161	8	aged	aged	ADJ
bibechana-80853	161	9	rat	rat	NOUN
bibechana-80853	161	10	vascular	vascular	ADJ
bibechana-80853	161	11	smooth	smooth	ADJ
bibechana-80853	161	12	muscle	muscle	NOUN
bibechana-80853	161	13	cells	cell	NOUN
bibechana-80853	161	14	promotes	promote	VERB
bibechana-80853	161	15	a	a	DET
bibechana-80853	161	16	proinflammatory	proinflammatory	ADJ
bibechana-80853	161	17	phenotype	phenotype	NOUN
bibechana-80853	161	18	via	via	ADP
bibechana-80853	161	19	erk1/2	erk1/2	PROPN
bibechana-80853	161	20	mapk	mapk	NOUN
bibechana-80853	161	21	and	and	CCONJ
bibechana-80853	161	22	egfrdependent	egfrdependent	ADJ
bibechana-80853	161	23	pathway	pathway	NOUN
bibechana-80853	161	24	.	.	PUNCT
bibechana-80853	162	1	hypertension	hypertension	NOUN
bibechana-80853	162	2	,	,	PUNCT
bibechana-80853	162	3	55(6):1476	55(6):1476	NUM
bibechana-80853	162	4	–	–	PUNCT
bibechana-80853	162	5	1483	1483	NUM
bibechana-80853	162	6	,	,	PUNCT
bibechana-80853	162	7	2010	2010	NUM
bibechana-80853	162	8	.	.	PUNCT
bibechana-80853	163	1	ram	ram	PROPN
bibechana-80853	163	2	lal	lal	PROPN
bibechana-80853	163	3	(	(	PUNCT
bibechana-80853	163	4	swagat	swagat	ADJ
bibechana-80853	163	5	)	)	PUNCT
bibechana-80853	163	6	shrestha	shrestha	NOUN
bibechana-80853	163	7	et	et	PROPN
bibechana-80853	164	1	al./	al./	ADV
bibechana-80853	164	2	bibechana	bibechana	PROPN
bibechana-80853	164	3	22	22	NUM
bibechana-80853	164	4	(	(	PUNCT
bibechana-80853	164	5	2025	2025	NUM
bibechana-80853	164	6	)	)	PUNCT
bibechana-80853	164	7	291	291	NUM
bibechana-80853	164	8	-	-	SYM
bibechana-80853	164	9	298	298	NUM
bibechana-80853	164	10	297	297	NUM
bibechana-80853	164	11	[	[	X
bibechana-80853	164	12	7	7	NUM
bibechana-80853	164	13	]	]	ADJ
bibechana-80853	164	14	i.	i.	PROPN
bibechana-80853	164	15	z.	z.	PROPN
bibechana-80853	164	16	jaffe	jaffe	PROPN
bibechana-80853	164	17	and	and	CCONJ
bibechana-80853	164	18	m.	m.	PROPN
bibechana-80853	164	19	e.	e.	PROPN
bibechana-80853	164	20	mendelsohn	mendelsohn	PROPN
bibechana-80853	164	21	.	.	PUNCT
bibechana-80853	165	1	angiotensin	angiotensin	PROPN
bibechana-80853	165	2	ii	ii	PROPN
bibechana-80853	165	3	and	and	CCONJ
bibechana-80853	165	4	aldosterone	aldosterone	NOUN
bibechana-80853	165	5	regulate	regulate	NOUN
bibechana-80853	165	6	gene	gene	NOUN
bibechana-80853	165	7	transcription	transcription	NOUN
bibechana-80853	165	8	via	via	ADP
bibechana-80853	165	9	functional	functional	ADJ
bibechana-80853	165	10	mineralocortocoid	mineralocortocoid	ADJ
bibechana-80853	165	11	receptors	receptor	NOUN
bibechana-80853	165	12	in	in	ADP
bibechana-80853	165	13	human	human	ADJ
bibechana-80853	165	14	coronary	coronary	ADJ
bibechana-80853	165	15	artery	artery	NOUN
bibechana-80853	165	16	smooth	smooth	ADJ
bibechana-80853	165	17	muscle	muscle	NOUN
bibechana-80853	165	18	cells	cell	NOUN
bibechana-80853	165	19	.	.	PUNCT
bibechana-80853	166	1	circulation	circulation	NOUN
bibechana-80853	166	2	research	research	NOUN
bibechana-80853	166	3	,	,	PUNCT
bibechana-80853	166	4	96(6):643–650	96(6):643–650	PROPN
bibechana-80853	166	5	,	,	PUNCT
bibechana-80853	166	6	2005	2005	NUM
bibechana-80853	166	7	.	.	PUNCT
bibechana-80853	167	1	[	[	X
bibechana-80853	167	2	8	8	NUM
bibechana-80853	167	3	]	]	X
bibechana-80853	167	4	f.	f.	PROPN
bibechana-80853	167	5	moncloa	moncloa	PROPN
bibechana-80853	167	6	,	,	PUNCT
bibechana-80853	167	7	j.	j.	PROPN
bibechana-80853	167	8	a.	a.	PROPN
bibechana-80853	167	9	sromovsky	sromovsky	PROPN
bibechana-80853	167	10	,	,	PUNCT
bibechana-80853	167	11	j.	j.	PROPN
bibechana-80853	167	12	f.	f.	PROPN
bibechana-80853	167	13	walker	walker	PROPN
bibechana-80853	167	14	,	,	PUNCT
bibechana-80853	167	15	and	and	CCONJ
bibechana-80853	167	16	r.	r.	PROPN
bibechana-80853	167	17	o.	o.	PROPN
bibechana-80853	167	18	davies	davies	PROPN
bibechana-80853	167	19	.	.	PUNCT
bibechana-80853	168	1	enalapril	enalapril	NOUN
bibechana-80853	168	2	in	in	ADP
bibechana-80853	168	3	hypertension	hypertension	NOUN
bibechana-80853	168	4	and	and	CCONJ
bibechana-80853	168	5	congestive	congestive	ADJ
bibechana-80853	168	6	heart	heart	NOUN
bibechana-80853	168	7	failure	failure	NOUN
bibechana-80853	168	8	.	.	PUNCT
bibechana-80853	169	1	drugs	drug	NOUN
bibechana-80853	169	2	,	,	PUNCT
bibechana-80853	169	3	30(suppl	30(suppl	NUM
bibechana-80853	169	4	1):82–89	1):82–89	NUM
bibechana-80853	169	5	,	,	PUNCT
bibechana-80853	169	6	1985	1985	NUM
bibechana-80853	169	7	.	.	PUNCT
bibechana-80853	170	1	[	[	X
bibechana-80853	170	2	9	9	NUM
bibechana-80853	170	3	]	]	PUNCT
bibechana-80853	170	4	p.	p.	NOUN
bibechana-80853	170	5	wang	wang	PROPN
bibechana-80853	170	6	,	,	PUNCT
bibechana-80853	170	7	l.	l.	PROPN
bibechana-80853	170	8	wang	wang	PROPN
bibechana-80853	170	9	,	,	PUNCT
bibechana-80853	170	10	z.	z.	PROPN
bibechana-80853	170	11	liu	liu	PROPN
bibechana-80853	170	12	,	,	PUNCT
bibechana-80853	170	13	and	and	CCONJ
bibechana-80853	170	14	j.	j.	PROPN
bibechana-80853	170	15	feng	feng	PROPN
bibechana-80853	170	16	.	.	PUNCT
bibechana-80853	171	1	safety	safety	NOUN
bibechana-80853	171	2	and	and	CCONJ
bibechana-80853	171	3	efficacy	efficacy	NOUN
bibechana-80853	171	4	of	of	ADP
bibechana-80853	171	5	enalapril	enalapril	PROPN
bibechana-80853	171	6	combined	combine	VERB
bibechana-80853	171	7	with	with	ADP
bibechana-80853	171	8	metoprolol	metoprolol	NOUN
bibechana-80853	171	9	in	in	ADP
bibechana-80853	171	10	patients	patient	NOUN
bibechana-80853	171	11	of	of	ADP
bibechana-80853	171	12	hypertension	hypertension	NOUN
bibechana-80853	171	13	complicated	complicate	VERB
bibechana-80853	171	14	with	with	ADP
bibechana-80853	171	15	coronary	coronary	ADJ
bibechana-80853	171	16	heart	heart	NOUN
bibechana-80853	171	17	disease	disease	NOUN
bibechana-80853	171	18	:	:	PUNCT
bibechana-80853	171	19	a	a	DET
bibechana-80853	171	20	randomised	randomised	ADJ
bibechana-80853	171	21	clinical	clinical	ADJ
bibechana-80853	171	22	trial	trial	NOUN
bibechana-80853	171	23	.	.	PUNCT
bibechana-80853	172	1	journal	journal	NOUN
bibechana-80853	172	2	of	of	ADP
bibechana-80853	172	3	clinical	clinical	ADJ
bibechana-80853	172	4	and	and	CCONJ
bibechana-80853	172	5	diagnostic	diagnostic	ADJ
bibechana-80853	172	6	research	research	NOUN
bibechana-80853	172	7	,	,	PUNCT
bibechana-80853	172	8	pages	page	NOUN
bibechana-80853	172	9	15–20	15–20	NUM
bibechana-80853	172	10	,	,	PUNCT
bibechana-80853	172	11	2022	2022	NUM
bibechana-80853	172	12	.	.	PUNCT
bibechana-80853	173	1	[	[	X
bibechana-80853	173	2	10	10	NUM
bibechana-80853	173	3	]	]	X
bibechana-80853	173	4	r.	r.	PROPN
bibechana-80853	173	5	l.	l.	PROPN
bibechana-80853	173	6	s.	s.	PROPN
bibechana-80853	173	7	shrestha	shrestha	PROPN
bibechana-80853	173	8	,	,	PUNCT
bibechana-80853	173	9	b.	b.	PROPN
bibechana-80853	173	10	maharjan	maharjan	PROPN
bibechana-80853	173	11	,	,	PUNCT
bibechana-80853	173	12	t.	t.	PROPN
bibechana-80853	173	13	shrestha	shrestha	PROPN
bibechana-80853	173	14	,	,	PUNCT
bibechana-80853	173	15	b.	b.	PROPN
bibechana-80853	173	16	p.	p.	PROPN
bibechana-80853	173	17	marasini	marasini	PROPN
bibechana-80853	173	18	,	,	PUNCT
bibechana-80853	173	19	and	and	CCONJ
bibechana-80853	173	20	j.	j.	PROPN
bibechana-80853	173	21	adhikari	adhikari	PROPN
bibechana-80853	173	22	subin	subin	PROPN
bibechana-80853	173	23	.	.	PUNCT
bibechana-80853	174	1	geometrical	geometrical	ADJ
bibechana-80853	174	2	and	and	CCONJ
bibechana-80853	174	3	thermodynamic	thermodynamic	ADJ
bibechana-80853	174	4	stability	stability	NOUN
bibechana-80853	174	5	of	of	ADP
bibechana-80853	174	6	govaniadine	govaniadine	NOUN
bibechana-80853	174	7	scaffold	scaffold	NOUN
bibechana-80853	174	8	adducts	adduct	NOUN
bibechana-80853	174	9	with	with	ADP
bibechana-80853	174	10	dopamine	dopamine	NOUN
bibechana-80853	174	11	receptor	receptor	NOUN
bibechana-80853	174	12	d1	d1	PROPN
bibechana-80853	174	13	.	.	PUNCT
bibechana-80853	175	1	results	result	NOUN
bibechana-80853	175	2	in	in	ADP
bibechana-80853	175	3	chemistry	chemistry	NOUN
bibechana-80853	175	4	,	,	PUNCT
bibechana-80853	175	5	7:101363	7:101363	NUM
bibechana-80853	175	6	,	,	PUNCT
bibechana-80853	175	7	january	january	PROPN
bibechana-80853	175	8	2024	2024	NUM
bibechana-80853	175	9	.	.	PUNCT
bibechana-80853	176	1	[	[	X
bibechana-80853	176	2	11	11	NUM
bibechana-80853	176	3	]	]	PUNCT
bibechana-80853	176	4	s.	s.	PROPN
bibechana-80853	176	5	alam	alam	PROPN
bibechana-80853	176	6	et	et	PROPN
bibechana-80853	176	7	al	al	PROPN
bibechana-80853	176	8	.	.	PROPN
bibechana-80853	177	1	antidiabetic	antidiabetic	ADJ
bibechana-80853	177	2	phytochemicals	phytochemical	NOUN
bibechana-80853	177	3	from	from	ADP
bibechana-80853	177	4	medicinal	medicinal	ADJ
bibechana-80853	177	5	plants	plant	NOUN
bibechana-80853	177	6	:	:	PUNCT
bibechana-80853	177	7	prospective	prospective	ADJ
bibechana-80853	177	8	candidates	candidate	NOUN
bibechana-80853	177	9	for	for	ADP
bibechana-80853	177	10	new	new	ADJ
bibechana-80853	177	11	drug	drug	NOUN
bibechana-80853	177	12	discovery	discovery	NOUN
bibechana-80853	177	13	and	and	CCONJ
bibechana-80853	177	14	development	development	NOUN
bibechana-80853	177	15	.	.	PUNCT
bibechana-80853	178	1	frontiers	frontier	NOUN
bibechana-80853	178	2	in	in	ADP
bibechana-80853	178	3	endocrinology	endocrinology	NOUN
bibechana-80853	178	4	,	,	PUNCT
bibechana-80853	178	5	13	13	NUM
bibechana-80853	178	6	,	,	PUNCT
bibechana-80853	178	7	2022	2022	NUM
bibechana-80853	178	8	.	.	PUNCT
bibechana-80853	179	1	[	[	X
bibechana-80853	179	2	12	12	NUM
bibechana-80853	179	3	]	]	PUNCT
bibechana-80853	179	4	m.	m.	PROPN
bibechana-80853	179	5	e.	e.	PROPN
bibechana-80853	179	6	hernández	hernández	PROPN
bibechana-80853	179	7	-	-	PUNCT
bibechana-80853	179	8	caballero	caballero	PROPN
bibechana-80853	179	9	,	,	PUNCT
bibechana-80853	179	10	j.	j.	PROPN
bibechana-80853	179	11	a.	a.	PROPN
bibechana-80853	179	12	sierraramírez	sierraramírez	PROPN
bibechana-80853	179	13	,	,	PUNCT
bibechana-80853	179	14	r.	r.	PROPN
bibechana-80853	179	15	villalobos	villalobos	PROPN
bibechana-80853	179	16	-	-	PUNCT
bibechana-80853	179	17	valencia	valencia	PROPN
bibechana-80853	179	18	,	,	PUNCT
bibechana-80853	179	19	and	and	CCONJ
bibechana-80853	179	20	e.	e.	PROPN
bibechana-80853	179	21	seseña	seseña	PROPN
bibechana-80853	179	22	-	-	PUNCT
bibechana-80853	179	23	méndez	méndez	NOUN
bibechana-80853	179	24	.	.	PUNCT
bibechana-80853	179	25	potential	potential	NOUN
bibechana-80853	179	26	of	of	ADP
bibechana-80853	179	27	kalanchoe	kalanchoe	NOUN
bibechana-80853	179	28	pinnata	pinnata	NOUN
bibechana-80853	179	29	as	as	ADP
bibechana-80853	179	30	a	a	DET
bibechana-80853	179	31	cancer	cancer	NOUN
bibechana-80853	179	32	treatment	treatment	NOUN
bibechana-80853	179	33	adjuvant	adjuvant	NOUN
bibechana-80853	179	34	and	and	CCONJ
bibechana-80853	179	35	an	an	DET
bibechana-80853	179	36	epigenetic	epigenetic	ADJ
bibechana-80853	179	37	regulator	regulator	NOUN
bibechana-80853	179	38	.	.	PUNCT
bibechana-80853	180	1	molecules	molecule	NOUN
bibechana-80853	180	2	,	,	PUNCT
bibechana-80853	180	3	27(19):6425	27(19):6425	NUM
bibechana-80853	180	4	,	,	PUNCT
bibechana-80853	180	5	september	september	PROPN
bibechana-80853	180	6	2022	2022	NUM
bibechana-80853	180	7	.	.	PUNCT
bibechana-80853	181	1	[	[	X
bibechana-80853	181	2	13	13	NUM
bibechana-80853	181	3	]	]	PUNCT
bibechana-80853	181	4	r.	r.	PROPN
bibechana-80853	181	5	rahman	rahman	PROPN
bibechana-80853	181	6	,	,	PUNCT
bibechana-80853	181	7	j.	j.	PROPN
bibechana-80853	181	8	n.	n.	PROPN
bibechana-80853	181	9	al	al	PROPN
bibechana-80853	181	10	-	-	PUNCT
bibechana-80853	181	11	sabahi	sabahi	PROPN
bibechana-80853	181	12	,	,	PUNCT
bibechana-80853	181	13	a.	a.	PROPN
bibechana-80853	181	14	ghaffar	ghaffar	PROPN
bibechana-80853	181	15	,	,	PUNCT
bibechana-80853	181	16	f.	f.	PROPN
bibechana-80853	181	17	nadeem	nadeem	PROPN
bibechana-80853	181	18	,	,	PUNCT
bibechana-80853	181	19	and	and	CCONJ
bibechana-80853	181	20	a.	a.	PROPN
bibechana-80853	181	21	umar	umar	PROPN
bibechana-80853	181	22	.	.	PUNCT
bibechana-80853	182	1	phytochemical	phytochemical	ADJ
bibechana-80853	182	2	,	,	PUNCT
bibechana-80853	182	3	morphological	morphological	ADJ
bibechana-80853	182	4	,	,	PUNCT
bibechana-80853	182	5	botanical	botanical	ADJ
bibechana-80853	182	6	,	,	PUNCT
bibechana-80853	182	7	and	and	CCONJ
bibechana-80853	182	8	pharmacological	pharmacological	ADJ
bibechana-80853	182	9	aspects	aspect	NOUN
bibechana-80853	182	10	of	of	ADP
bibechana-80853	182	11	a	a	DET
bibechana-80853	182	12	medicinal	medicinal	ADJ
bibechana-80853	182	13	plant	plant	NOUN
bibechana-80853	182	14	:	:	PUNCT
bibechana-80853	182	15	kalanchoe	kalanchoe	NOUN
bibechana-80853	182	16	pinnata	pinnata	NOUN
bibechana-80853	182	17	–	–	PUNCT
bibechana-80853	182	18	a	a	DET
bibechana-80853	182	19	review	review	NOUN
bibechana-80853	182	20	article	article	NOUN
bibechana-80853	182	21	.	.	PUNCT
bibechana-80853	183	1	international	international	ADJ
bibechana-80853	183	2	journal	journal	PROPN
bibechana-80853	183	3	of	of	ADP
bibechana-80853	183	4	chemical	chemical	ADJ
bibechana-80853	183	5	and	and	CCONJ
bibechana-80853	183	6	biochemical	biochemical	ADJ
bibechana-80853	183	7	sciences	science	NOUN
bibechana-80853	183	8	,	,	PUNCT
bibechana-80853	183	9	16:5	16:5	NUM
bibechana-80853	183	10	–	–	PUNCT
bibechana-80853	183	11	10	10	NUM
bibechana-80853	183	12	,	,	PUNCT
bibechana-80853	183	13	2019	2019	NUM
bibechana-80853	183	14	.	.	PUNCT
bibechana-80853	184	1	[	[	X
bibechana-80853	184	2	14	14	NUM
bibechana-80853	184	3	]	]	X
bibechana-80853	184	4	o.	o.	PROPN
bibechana-80853	184	5	s.	s.	PROPN
bibechana-80853	184	6	m.	m.	PROPN
bibechana-80853	184	7	bopda	bopda	PROPN
bibechana-80853	184	8	et	et	PROPN
bibechana-80853	184	9	al	al	PROPN
bibechana-80853	184	10	.	.	PROPN
bibechana-80853	185	1	antihypertensive	antihypertensive	ADJ
bibechana-80853	185	2	activities	activity	NOUN
bibechana-80853	185	3	of	of	ADP
bibechana-80853	185	4	the	the	DET
bibechana-80853	185	5	aqueous	aqueous	ADJ
bibechana-80853	185	6	extract	extract	NOUN
bibechana-80853	185	7	of	of	ADP
bibechana-80853	185	8	kalanchoe	kalanchoe	NOUN
bibechana-80853	185	9	pinnata	pinnata	NOUN
bibechana-80853	185	10	(	(	PUNCT
bibechana-80853	185	11	crassulaceae	crassulaceae	PROPN
bibechana-80853	185	12	)	)	PUNCT
bibechana-80853	185	13	in	in	ADP
bibechana-80853	185	14	high	high	ADJ
bibechana-80853	185	15	salt	salt	NOUN
bibechana-80853	185	16	-	-	PUNCT
bibechana-80853	185	17	loaded	load	VERB
bibechana-80853	185	18	rats	rat	NOUN
bibechana-80853	185	19	.	.	PUNCT
bibechana-80853	186	1	journal	journal	NOUN
bibechana-80853	186	2	of	of	ADP
bibechana-80853	186	3	ethnopharmacology	ethnopharmacology	NOUN
bibechana-80853	186	4	,	,	PUNCT
bibechana-80853	186	5	153(2):400	153(2):400	NUM
bibechana-80853	186	6	–	–	PUNCT
bibechana-80853	186	7	407	407	NUM
bibechana-80853	186	8	,	,	PUNCT
bibechana-80853	186	9	2014	2014	NUM
bibechana-80853	186	10	.	.	PUNCT
bibechana-80853	187	1	[	[	X
bibechana-80853	187	2	15	15	NUM
bibechana-80853	187	3	]	]	X
bibechana-80853	187	4	p.	p.	PROPN
bibechana-80853	187	5	b.	b.	PROPN
bibechana-80853	187	6	rajsekhar	rajsekhar	PROPN
bibechana-80853	187	7	,	,	PUNCT
bibechana-80853	187	8	r.	r.	PROPN
bibechana-80853	187	9	s.	s.	PROPN
bibechana-80853	187	10	arvind	arvind	PROPN
bibechana-80853	187	11	bharani	bharani	PROPN
bibechana-80853	187	12	,	,	PUNCT
bibechana-80853	187	13	m.	m.	NOUN
bibechana-80853	187	14	ramachandran	ramachandran	PROPN
bibechana-80853	187	15	,	,	PUNCT
bibechana-80853	187	16	k.	k.	PROPN
bibechana-80853	187	17	jini	jini	PROPN
bibechana-80853	187	18	angel	angel	PROPN
bibechana-80853	187	19	,	,	PUNCT
bibechana-80853	187	20	and	and	CCONJ
bibechana-80853	187	21	s.	s.	PROPN
bibechana-80853	187	22	p.	p.	PROPN
bibechana-80853	187	23	v.	v.	PROPN
bibechana-80853	187	24	rajsekhar	rajsekhar	PROPN
bibechana-80853	187	25	.	.	PUNCT
bibechana-80853	188	1	the	the	DET
bibechana-80853	188	2	‘	'	PUNCT
bibechana-80853	188	3	wonder	wonder	NOUN
bibechana-80853	188	4	plant	plant	NOUN
bibechana-80853	188	5	’	'	PUNCT
bibechana-80853	188	6	kalanchoe	kalanchoe	NOUN
bibechana-80853	188	7	pinnata	pinnata	NOUN
bibechana-80853	188	8	(	(	PUNCT
bibechana-80853	188	9	linn	linn	PROPN
bibechana-80853	188	10	.	.	PUNCT
bibechana-80853	188	11	)	)	PUNCT
bibechana-80853	188	12	pers	per	NOUN
bibechana-80853	188	13	.	.	PUNCT
bibechana-80853	188	14	:	:	PUNCT
bibechana-80853	188	15	a	a	DET
bibechana-80853	188	16	review	review	NOUN
bibechana-80853	188	17	.	.	PUNCT
bibechana-80853	189	1	journal	journal	PROPN
bibechana-80853	189	2	of	of	ADP
bibechana-80853	189	3	applied	apply	VERB
bibechana-80853	189	4	pharmaceutical	pharmaceutical	ADJ
bibechana-80853	189	5	science	science	NOUN
bibechana-80853	189	6	,	,	PUNCT
bibechana-80853	189	7	6(3):151–158	6(3):151–158	NOUN
bibechana-80853	189	8	,	,	PUNCT
bibechana-80853	189	9	2016	2016	NUM
bibechana-80853	189	10	.	.	PUNCT
bibechana-80853	190	1	[	[	X
bibechana-80853	190	2	16	16	NUM
bibechana-80853	190	3	]	]	PUNCT
bibechana-80853	190	4	m.	m.	PROPN
bibechana-80853	190	5	b.	b.	PROPN
bibechana-80853	191	1	os	os	PROPN
bibechana-80853	192	1	et	et	PROPN
bibechana-80853	193	1	al	al	PROPN
bibechana-80853	193	2	.	.	PROPN
bibechana-80853	193	3	cardioprotective	cardioprotective	ADJ
bibechana-80853	193	4	effects	effect	NOUN
bibechana-80853	193	5	of	of	ADP
bibechana-80853	193	6	kalanchoe	kalanchoe	NOUN
bibechana-80853	193	7	pinnata	pinnata	NOUN
bibechana-80853	193	8	aqueous	aqueous	ADJ
bibechana-80853	193	9	and	and	CCONJ
bibechana-80853	193	10	ethanolic	ethanolic	ADJ
bibechana-80853	193	11	extracts	extract	NOUN
bibechana-80853	193	12	in	in	ADP
bibechana-80853	193	13	wistar	wistar	PROPN
bibechana-80853	193	14	rat	rat	PROPN
bibechana-80853	193	15	.	.	PROPN
bibechana-80853	193	16	annals	annals	NOUN
bibechana-80853	193	17	of	of	ADP
bibechana-80853	193	18	hypertension	hypertension	NOUN
bibechana-80853	193	19	,	,	PUNCT
bibechana-80853	193	20	1(2):1–6	1(2):1–6	NUM
bibechana-80853	193	21	,	,	PUNCT
bibechana-80853	193	22	2019	2019	NUM
bibechana-80853	193	23	.	.	PUNCT
bibechana-80853	194	1	[	[	X
bibechana-80853	194	2	17	17	NUM
bibechana-80853	194	3	]	]	X
bibechana-80853	194	4	h.	h.	PROPN
bibechana-80853	194	5	gohlke	gohlke	PROPN
bibechana-80853	194	6	,	,	PUNCT
bibechana-80853	194	7	m.	m.	NOUN
bibechana-80853	194	8	hendlich	hendlich	PROPN
bibechana-80853	194	9	,	,	PUNCT
bibechana-80853	194	10	and	and	CCONJ
bibechana-80853	194	11	g.	g.	PROPN
bibechana-80853	194	12	klebe	klebe	NOUN
bibechana-80853	194	13	.	.	PUNCT
bibechana-80853	195	1	knowledge	knowledge	NOUN
bibechana-80853	195	2	-	-	PUNCT
bibechana-80853	195	3	based	base	VERB
bibechana-80853	195	4	scoring	scoring	NOUN
bibechana-80853	195	5	function	function	NOUN
bibechana-80853	195	6	to	to	PART
bibechana-80853	195	7	predict	predict	VERB
bibechana-80853	195	8	protein	protein	NOUN
bibechana-80853	195	9	-	-	PUNCT
bibechana-80853	195	10	ligand	ligand	NOUN
bibechana-80853	195	11	interactions	interaction	NOUN
bibechana-80853	195	12	.	.	PUNCT
bibechana-80853	196	1	journal	journal	NOUN
bibechana-80853	196	2	of	of	ADP
bibechana-80853	196	3	molecular	molecular	ADJ
bibechana-80853	196	4	biology	biology	NOUN
bibechana-80853	196	5	,	,	PUNCT
bibechana-80853	196	6	295(2):337–356	295(2):337–356	NUM
bibechana-80853	196	7	,	,	PUNCT
bibechana-80853	196	8	2000	2000	NUM
bibechana-80853	196	9	.	.	PUNCT
bibechana-80853	197	1	[	[	X
bibechana-80853	197	2	18	18	NUM
bibechana-80853	197	3	]	]	X
bibechana-80853	197	4	b.	b.	PROPN
bibechana-80853	197	5	shaker	shaker	PROPN
bibechana-80853	197	6	,	,	PUNCT
bibechana-80853	197	7	s.	s.	PROPN
bibechana-80853	197	8	ahmad	ahmad	PROPN
bibechana-80853	197	9	,	,	PUNCT
bibechana-80853	197	10	j.	j.	PROPN
bibechana-80853	197	11	lee	lee	PROPN
bibechana-80853	197	12	,	,	PUNCT
bibechana-80853	197	13	c.	c.	PROPN
bibechana-80853	197	14	jung	jung	PROPN
bibechana-80853	197	15	,	,	PUNCT
bibechana-80853	197	16	and	and	CCONJ
bibechana-80853	197	17	d.	d.	PROPN
bibechana-80853	197	18	na	na	PROPN
bibechana-80853	197	19	.	.	PUNCT
bibechana-80853	198	1	in	in	ADP
bibechana-80853	198	2	silico	silico	NOUN
bibechana-80853	198	3	methods	method	NOUN
bibechana-80853	198	4	and	and	CCONJ
bibechana-80853	198	5	tools	tool	NOUN
bibechana-80853	198	6	for	for	ADP
bibechana-80853	198	7	drug	drug	NOUN
bibechana-80853	198	8	discovery	discovery	NOUN
bibechana-80853	198	9	.	.	PUNCT
bibechana-80853	199	1	computers	computer	NOUN
bibechana-80853	199	2	in	in	ADP
bibechana-80853	199	3	biology	biology	NOUN
bibechana-80853	199	4	and	and	CCONJ
bibechana-80853	199	5	medicine	medicine	NOUN
bibechana-80853	199	6	,	,	PUNCT
bibechana-80853	199	7	137:104851	137:104851	PROPN
bibechana-80853	199	8	,	,	PUNCT
bibechana-80853	199	9	october	october	PROPN
bibechana-80853	199	10	2021	2021	NUM
bibechana-80853	199	11	.	.	PUNCT
bibechana-80853	200	1	[	[	X
bibechana-80853	200	2	19	19	NUM
bibechana-80853	200	3	]	]	PUNCT
bibechana-80853	200	4	v.	v.	CCONJ
bibechana-80853	200	5	s.	s.	PROPN
bibechana-80853	200	6	rao	rao	PROPN
bibechana-80853	200	7	and	and	CCONJ
bibechana-80853	200	8	k.	k.	PROPN
bibechana-80853	200	9	srinivas	srinivas	PROPN
bibechana-80853	200	10	.	.	PUNCT
bibechana-80853	201	1	modern	modern	ADJ
bibechana-80853	201	2	drug	drug	NOUN
bibechana-80853	201	3	discovery	discovery	NOUN
bibechana-80853	201	4	process	process	NOUN
bibechana-80853	201	5	:	:	PUNCT
bibechana-80853	201	6	an	an	PRON
bibechana-80853	201	7	in	in	ADP
bibechana-80853	201	8	silico	silico	NOUN
bibechana-80853	201	9	approach	approach	NOUN
bibechana-80853	201	10	.	.	PUNCT
bibechana-80853	202	1	journal	journal	NOUN
bibechana-80853	202	2	of	of	ADP
bibechana-80853	202	3	bioinformatics	bioinformatics	NOUN
bibechana-80853	202	4	and	and	CCONJ
bibechana-80853	202	5	sequence	sequence	NOUN
bibechana-80853	202	6	analysis	analysis	NOUN
bibechana-80853	202	7	,	,	PUNCT
bibechana-80853	202	8	2(june):89–94	2(june):89–94	NUM
bibechana-80853	202	9	,	,	PUNCT
bibechana-80853	202	10	2011	2011	NUM
bibechana-80853	202	11	.	.	PUNCT
bibechana-80853	203	1	available	available	ADJ
bibechana-80853	203	2	online	online	ADV
bibechana-80853	203	3	:	:	PUNCT
bibechana-80853	204	1	http	http	ADJ
bibechana-80853	204	2	:	:	PUNCT
bibechana-80853	204	3	//www.academicjournals.org	//www.academicjournals.org	PUNCT
bibechana-80853	204	4	/	/	SYM
bibechana-80853	204	5	jbsa	jbsa	PROPN
bibechana-80853	204	6	.	.	PUNCT
bibechana-80853	205	1	[	[	X
bibechana-80853	205	2	20	20	NUM
bibechana-80853	205	3	]	]	PUNCT
bibechana-80853	205	4	r.	r.	PROPN
bibechana-80853	205	5	shrestha	shrestha	PROPN
bibechana-80853	205	6	et	et	PROPN
bibechana-80853	205	7	al	al	PROPN
bibechana-80853	205	8	.	.	PROPN
bibechana-80853	205	9	selected	select	VERB
bibechana-80853	205	10	phytochemicals	phytochemical	NOUN
bibechana-80853	205	11	as	as	ADP
bibechana-80853	205	12	potent	potent	ADJ
bibechana-80853	205	13	acetylcholinesterase	acetylcholinesterase	NOUN
bibechana-80853	205	14	inhibitors	inhibitor	NOUN
bibechana-80853	205	15	:	:	PUNCT
bibechana-80853	205	16	an	an	PRON
bibechana-80853	205	17	in	in	ADP
bibechana-80853	205	18	silico	silico	NOUN
bibechana-80853	205	19	prediction	prediction	NOUN
bibechana-80853	205	20	.	.	PUNCT
bibechana-80853	206	1	journal	journal	NOUN
bibechana-80853	206	2	of	of	ADP
bibechana-80853	206	3	the	the	DET
bibechana-80853	206	4	serbian	serbian	ADJ
bibechana-80853	206	5	chemical	chemical	NOUN
bibechana-80853	206	6	society	society	NOUN
bibechana-80853	206	7	,	,	PUNCT
bibechana-80853	206	8	pages	page	NOUN
bibechana-80853	206	9	1–14	1–14	PROPN
bibechana-80853	206	10	,	,	PUNCT
bibechana-80853	206	11	2024	2024	NUM
bibechana-80853	206	12	.	.	PUNCT
bibechana-80853	207	1	[	[	X
bibechana-80853	207	2	21	21	NUM
bibechana-80853	207	3	]	]	PUNCT
bibechana-80853	207	4	p.	p.	NOUN
bibechana-80853	207	5	burkhard	burkhard	PROPN
bibechana-80853	207	6	,	,	PUNCT
bibechana-80853	207	7	u.	u.	PROPN
bibechana-80853	207	8	hommel	hommel	PROPN
bibechana-80853	207	9	,	,	PUNCT
bibechana-80853	207	10	m.	m.	NOUN
bibechana-80853	207	11	sanner	sanner	NOUN
bibechana-80853	207	12	,	,	PUNCT
bibechana-80853	207	13	and	and	CCONJ
bibechana-80853	207	14	m.	m.	PROPN
bibechana-80853	207	15	d.	d.	PROPN
bibechana-80853	207	16	walkinshaw	walkinshaw	PROPN
bibechana-80853	207	17	.	.	PUNCT
bibechana-80853	208	1	the	the	DET
bibechana-80853	208	2	discovery	discovery	NOUN
bibechana-80853	208	3	of	of	ADP
bibechana-80853	208	4	steroids	steroid	NOUN
bibechana-80853	208	5	and	and	CCONJ
bibechana-80853	208	6	other	other	ADJ
bibechana-80853	208	7	novel	novel	ADJ
bibechana-80853	208	8	fkbp	fkbp	ADJ
bibechana-80853	208	9	inhibitors	inhibitor	NOUN
bibechana-80853	208	10	using	use	VERB
bibechana-80853	208	11	a	a	DET
bibechana-80853	208	12	molecular	molecular	ADJ
bibechana-80853	208	13	docking	docking	NOUN
bibechana-80853	208	14	program	program	NOUN
bibechana-80853	208	15	.	.	PUNCT
bibechana-80853	209	1	journal	journal	NOUN
bibechana-80853	209	2	of	of	ADP
bibechana-80853	209	3	molecular	molecular	ADJ
bibechana-80853	209	4	biology	biology	NOUN
bibechana-80853	209	5	,	,	PUNCT
bibechana-80853	209	6	287(5):853–858	287(5):853–858	NUM
bibechana-80853	209	7	,	,	PUNCT
bibechana-80853	209	8	1999	1999	NUM
bibechana-80853	209	9	.	.	PUNCT
bibechana-80853	210	1	[	[	X
bibechana-80853	210	2	22	22	NUM
bibechana-80853	210	3	]	]	X
bibechana-80853	210	4	s.	s.	PROPN
bibechana-80853	210	5	gupta	gupta	PROPN
bibechana-80853	210	6	et	et	PROPN
bibechana-80853	210	7	al	al	PROPN
bibechana-80853	210	8	.	.	PUNCT
bibechana-80853	210	9	identification	identification	NOUN
bibechana-80853	210	10	of	of	ADP
bibechana-80853	210	11	potential	potential	ADJ
bibechana-80853	210	12	natural	natural	ADJ
bibechana-80853	210	13	inhibitors	inhibitor	NOUN
bibechana-80853	210	14	of	of	ADP
bibechana-80853	210	15	sars	sar	NOUN
bibechana-80853	210	16	-	-	PUNCT
bibechana-80853	210	17	cov2	cov2	PROPN
bibechana-80853	210	18	main	main	ADJ
bibechana-80853	210	19	protease	protease	NOUN
bibechana-80853	210	20	by	by	ADP
bibechana-80853	210	21	molecular	molecular	ADJ
bibechana-80853	210	22	docking	docking	NOUN
bibechana-80853	210	23	and	and	CCONJ
bibechana-80853	210	24	simulation	simulation	NOUN
bibechana-80853	210	25	studies	study	NOUN
bibechana-80853	210	26	.	.	PUNCT
bibechana-80853	211	1	journal	journal	PROPN
bibechana-80853	211	2	of	of	ADP
bibechana-80853	211	3	biomolecular	biomolecular	ADJ
bibechana-80853	211	4	structure	structure	NOUN
bibechana-80853	211	5	and	and	CCONJ
bibechana-80853	211	6	dynamics	dynamic	NOUN
bibechana-80853	211	7	,	,	PUNCT
bibechana-80853	211	8	39(12):4334–4345	39(12):4334–4345	NUM
bibechana-80853	211	9	,	,	PUNCT
bibechana-80853	211	10	2021	2021	NUM
bibechana-80853	211	11	.	.	PUNCT
bibechana-80853	212	1	[	[	X
bibechana-80853	212	2	23	23	NUM
bibechana-80853	212	3	]	]	PUNCT
bibechana-80853	212	4	s.	s.	PROPN
bibechana-80853	212	5	kim	kim	PROPN
bibechana-80853	212	6	et	et	PROPN
bibechana-80853	212	7	al	al	PROPN
bibechana-80853	212	8	.	.	PROPN
bibechana-80853	212	9	pubchem	pubchem	NOUN
bibechana-80853	212	10	2023	2023	NUM
bibechana-80853	212	11	update	update	NOUN
bibechana-80853	212	12	.	.	PUNCT
bibechana-80853	213	1	nucleic	nucleic	ADJ
bibechana-80853	213	2	acids	acid	NOUN
bibechana-80853	213	3	research	research	NOUN
bibechana-80853	213	4	,	,	PUNCT
bibechana-80853	213	5	51:1373–1380	51:1373–1380	NOUN
bibechana-80853	213	6	,	,	PUNCT
bibechana-80853	213	7	2023	2023	NUM
bibechana-80853	213	8	.	.	PUNCT
bibechana-80853	214	1	[	[	X
bibechana-80853	214	2	24	24	NUM
bibechana-80853	214	3	]	]	X
bibechana-80853	214	4	j.	j.	PROPN
bibechana-80853	214	5	nickel	nickel	PROPN
bibechana-80853	214	6	et	et	PROPN
bibechana-80853	214	7	al	al	PROPN
bibechana-80853	214	8	.	.	PROPN
bibechana-80853	214	9	superpred	superpre	VERB
bibechana-80853	214	10	:	:	PUNCT
bibechana-80853	214	11	update	update	NOUN
bibechana-80853	214	12	on	on	ADP
bibechana-80853	214	13	drug	drug	NOUN
bibechana-80853	214	14	classification	classification	NOUN
bibechana-80853	214	15	and	and	CCONJ
bibechana-80853	214	16	target	target	NOUN
bibechana-80853	214	17	prediction	prediction	NOUN
bibechana-80853	214	18	.	.	PUNCT
bibechana-80853	215	1	nucleic	nucleic	ADJ
bibechana-80853	215	2	acids	acid	NOUN
bibechana-80853	215	3	research	research	NOUN
bibechana-80853	215	4	,	,	PUNCT
bibechana-80853	215	5	42(w1):26–31	42(w1):26–31	PROPN
bibechana-80853	215	6	,	,	PUNCT
bibechana-80853	215	7	2014	2014	NUM
bibechana-80853	215	8	.	.	PUNCT
bibechana-80853	216	1	[	[	X
bibechana-80853	216	2	25	25	NUM
bibechana-80853	216	3	]	]	PUNCT
bibechana-80853	216	4	m.	m.	PROPN
bibechana-80853	216	5	d.	d.	PROPN
bibechana-80853	216	6	hanwell	hanwell	PROPN
bibechana-80853	216	7	,	,	PUNCT
bibechana-80853	216	8	d.	d.	PROPN
bibechana-80853	216	9	e.	e.	PROPN
bibechana-80853	216	10	curtis	curtis	PROPN
bibechana-80853	216	11	,	,	PUNCT
bibechana-80853	216	12	d.	d.	PROPN
bibechana-80853	216	13	c.	c.	PROPN
bibechana-80853	216	14	lonie	lonie	PROPN
bibechana-80853	216	15	,	,	PUNCT
bibechana-80853	216	16	t.	t.	PROPN
bibechana-80853	216	17	vandermeersch	vandermeersch	PROPN
bibechana-80853	216	18	,	,	PUNCT
bibechana-80853	216	19	e.	e.	PROPN
bibechana-80853	216	20	zurek	zurek	PROPN
bibechana-80853	216	21	,	,	PUNCT
bibechana-80853	216	22	and	and	CCONJ
bibechana-80853	216	23	g.	g.	PROPN
bibechana-80853	216	24	r.	r.	PROPN
bibechana-80853	216	25	hutchison	hutchison	PROPN
bibechana-80853	216	26	.	.	PUNCT
bibechana-80853	217	1	avogadro	avogadro	PROPN
bibechana-80853	217	2	:	:	PUNCT
bibechana-80853	217	3	an	an	DET
bibechana-80853	217	4	advanced	advanced	ADJ
bibechana-80853	217	5	semantic	semantic	ADJ
bibechana-80853	217	6	chemical	chemical	NOUN
bibechana-80853	217	7	editor	editor	NOUN
bibechana-80853	217	8	,	,	PUNCT
bibechana-80853	217	9	visualization	visualization	NOUN
bibechana-80853	217	10	,	,	PUNCT
bibechana-80853	217	11	and	and	CCONJ
bibechana-80853	217	12	analysis	analysis	NOUN
bibechana-80853	217	13	platform	platform	NOUN
bibechana-80853	217	14	.	.	PUNCT
bibechana-80853	218	1	journal	journal	PROPN
bibechana-80853	218	2	of	of	ADP
bibechana-80853	218	3	cheminformatics	cheminformatic	NOUN
bibechana-80853	218	4	,	,	PUNCT
bibechana-80853	218	5	4(17	4(17	NUM
bibechana-80853	218	6	)	)	PUNCT
bibechana-80853	218	7	,	,	PUNCT
bibechana-80853	218	8	2012	2012	NUM
bibechana-80853	218	9	.	.	PUNCT
bibechana-80853	219	1	[	[	X
bibechana-80853	219	2	26	26	NUM
bibechana-80853	219	3	]	]	PUNCT
bibechana-80853	219	4	b.	b.	PROPN
bibechana-80853	219	5	rayan	rayan	PROPN
bibechana-80853	219	6	and	and	CCONJ
bibechana-80853	219	7	a.	a.	PROPN
bibechana-80853	219	8	rayan	rayan	PROPN
bibechana-80853	219	9	.	.	PUNCT
bibechana-80853	220	1	avogadro	avogadro	PROPN
bibechana-80853	220	2	program	program	NOUN
bibechana-80853	220	3	for	for	ADP
bibechana-80853	220	4	chemistry	chemistry	NOUN
bibechana-80853	220	5	education	education	NOUN
bibechana-80853	220	6	:	:	PUNCT
bibechana-80853	220	7	to	to	ADP
bibechana-80853	220	8	what	what	DET
bibechana-80853	220	9	extent	extent	NOUN
bibechana-80853	220	10	can	can	AUX
bibechana-80853	220	11	molecular	molecular	ADJ
bibechana-80853	220	12	visualization	visualization	NOUN
bibechana-80853	220	13	and	and	CCONJ
bibechana-80853	220	14	threedimensional	threedimensional	ADJ
bibechana-80853	220	15	simulations	simulation	NOUN
bibechana-80853	220	16	enhance	enhance	VERB
bibechana-80853	220	17	meaningful	meaningful	ADJ
bibechana-80853	220	18	chemistry	chemistry	NOUN
bibechana-80853	220	19	learning	learning	NOUN
bibechana-80853	220	20	?	?	PUNCT
bibechana-80853	221	1	world	world	PROPN
bibechana-80853	221	2	journal	journal	PROPN
bibechana-80853	221	3	of	of	ADP
bibechana-80853	221	4	chemical	chemical	PROPN
bibechana-80853	221	5	education	education	NOUN
bibechana-80853	221	6	,	,	PUNCT
bibechana-80853	221	7	5(4):136–141	5(4):136–141	NUM
bibechana-80853	221	8	,	,	PUNCT
bibechana-80853	221	9	2017	2017	NUM
bibechana-80853	221	10	.	.	PUNCT
bibechana-80853	222	1	[	[	X
bibechana-80853	222	2	27	27	NUM
bibechana-80853	222	3	]	]	X
bibechana-80853	222	4	e.	e.	PROPN
bibechana-80853	222	5	y.	y.	PROPN
bibechana-80853	222	6	salifu	salifu	PROPN
bibechana-80853	222	7	,	,	PUNCT
bibechana-80853	222	8	j.	j.	PROPN
bibechana-80853	222	9	abugri	abugri	PROPN
bibechana-80853	222	10	,	,	PUNCT
bibechana-80853	222	11	i.	i.	PROPN
bibechana-80853	222	12	a.	a.	PROPN
bibechana-80853	222	13	rashid	rashid	PROPN
bibechana-80853	222	14	,	,	PUNCT
bibechana-80853	222	15	f.	f.	PROPN
bibechana-80853	222	16	osei	osei	PROPN
bibechana-80853	222	17	,	,	PUNCT
bibechana-80853	222	18	and	and	CCONJ
bibechana-80853	222	19	j.	j.	PROPN
bibechana-80853	222	20	a.	a.	PROPN
bibechana-80853	222	21	ayariga	ayariga	PROPN
bibechana-80853	222	22	.	.	PUNCT
bibechana-80853	223	1	in	in	ADP
bibechana-80853	223	2	silico	silico	NOUN
bibechana-80853	223	3	identification	identification	NOUN
bibechana-80853	223	4	of	of	ADP
bibechana-80853	223	5	potential	potential	ADJ
bibechana-80853	223	6	inhibitors	inhibitor	NOUN
bibechana-80853	223	7	of	of	ADP
bibechana-80853	223	8	acyl	acyl	NOUN
bibechana-80853	223	9	carrier	carrier	NOUN
bibechana-80853	223	10	protein	protein	NOUN
bibechana-80853	223	11	reductase	reductase	NOUN
bibechana-80853	223	12	and	and	CCONJ
bibechana-80853	223	13	acetyl	acetyl	NOUN
bibechana-80853	223	14	coa	coa	NOUN
bibechana-80853	223	15	carboxylase	carboxylase	NOUN
bibechana-80853	223	16	of	of	ADP
bibechana-80853	223	17	plasmodium	plasmodium	NOUN
bibechana-80853	223	18	falciparum	falciparum	NOUN
bibechana-80853	223	19	in	in	ADP
bibechana-80853	223	20	antimalarial	antimalarial	ADJ
bibechana-80853	223	21	therapy	therapy	NOUN
bibechana-80853	223	22	.	.	PUNCT
bibechana-80853	224	1	frontiers	frontier	NOUN
bibechana-80853	224	2	in	in	ADP
bibechana-80853	224	3	drug	drug	NOUN
bibechana-80853	224	4	discovery	discovery	NOUN
bibechana-80853	224	5	,	,	PUNCT
bibechana-80853	224	6	3	3	NUM
bibechana-80853	224	7	,	,	PUNCT
bibechana-80853	224	8	2023	2023	NUM
bibechana-80853	224	9	.	.	PUNCT
bibechana-80853	225	1	http://www.academicjournals.org/jbsa	http://www.academicjournals.org/jbsa	X
bibechana-80853	225	2	http://www.academicjournals.org/jbsa	http://www.academicjournals.org/jbsa	X
bibechana-80853	225	3	ram	ram	PROPN
bibechana-80853	225	4	lal	lal	PROPN
bibechana-80853	225	5	(	(	PUNCT
bibechana-80853	225	6	swagat	swagat	ADJ
bibechana-80853	225	7	)	)	PUNCT
bibechana-80853	225	8	shrestha	shrestha	NOUN
bibechana-80853	225	9	et	et	PROPN
bibechana-80853	226	1	al./	al./	ADV
bibechana-80853	226	2	bibechana	bibechana	PROPN
bibechana-80853	226	3	22	22	NUM
bibechana-80853	226	4	(	(	PUNCT
bibechana-80853	226	5	2025	2025	NUM
bibechana-80853	226	6	)	)	PUNCT
bibechana-80853	226	7	291	291	NUM
bibechana-80853	226	8	-	-	SYM
bibechana-80853	226	9	298	298	NUM
bibechana-80853	226	10	298	298	NUM
bibechana-80853	227	1	[	[	X
bibechana-80853	227	2	28	28	NUM
bibechana-80853	227	3	]	]	SYM
bibechana-80853	227	4	i̇.	i̇.	PROPN
bibechana-80853	227	5	h.	h.	PROPN
bibechana-80853	227	6	ciğerci	ciğerci	PROPN
bibechana-80853	227	7	et	et	PROPN
bibechana-80853	227	8	al	al	PROPN
bibechana-80853	227	9	.	.	PUNCT
bibechana-80853	228	1	cyto	cyto	PROPN
bibechana-80853	228	2	-	-	PUNCT
bibechana-80853	228	3	genotoxic	genotoxic	ADJ
bibechana-80853	228	4	and	and	CCONJ
bibechana-80853	228	5	behavioral	behavioral	ADJ
bibechana-80853	228	6	effects	effect	NOUN
bibechana-80853	228	7	of	of	ADP
bibechana-80853	228	8	flubendiamide	flubendiamide	NOUN
bibechana-80853	228	9	in	in	ADP
bibechana-80853	228	10	allium	allium	NOUN
bibechana-80853	228	11	cepa	cepa	NOUN
bibechana-80853	228	12	root	root	NOUN
bibechana-80853	228	13	cells	cell	NOUN
bibechana-80853	228	14	,	,	PUNCT
bibechana-80853	228	15	drosophila	drosophila	NOUN
bibechana-80853	228	16	melanogaster	melanogaster	NOUN
bibechana-80853	228	17	and	and	CCONJ
bibechana-80853	228	18	molecular	molecular	ADJ
bibechana-80853	228	19	docking	docking	NOUN
bibechana-80853	228	20	studies	study	NOUN
bibechana-80853	228	21	.	.	PUNCT
bibechana-80853	229	1	international	international	ADJ
bibechana-80853	229	2	journal	journal	NOUN
bibechana-80853	229	3	of	of	ADP
bibechana-80853	229	4	molecular	molecular	ADJ
bibechana-80853	229	5	sciences	science	NOUN
bibechana-80853	229	6	,	,	PUNCT
bibechana-80853	229	7	24(2	24(2	NUM
bibechana-80853	229	8	)	)	PUNCT
bibechana-80853	229	9	,	,	PUNCT
bibechana-80853	229	10	2023	2023	NUM
bibechana-80853	229	11	.	.	PUNCT
bibechana-80853	230	1	[	[	X
bibechana-80853	230	2	29	29	NUM
bibechana-80853	230	3	]	]	X
bibechana-80853	230	4	d.	d.	PROPN
bibechana-80853	230	5	yusuf	yusuf	PROPN
bibechana-80853	230	6	,	,	PUNCT
bibechana-80853	230	7	a.	a.	PROPN
bibechana-80853	230	8	m.	m.	PROPN
bibechana-80853	230	9	davis	davis	PROPN
bibechana-80853	230	10	,	,	PUNCT
bibechana-80853	230	11	g.	g.	PROPN
bibechana-80853	230	12	j.	j.	PROPN
bibechana-80853	230	13	kleywegt	kleywegt	PROPN
bibechana-80853	230	14	,	,	PUNCT
bibechana-80853	230	15	and	and	CCONJ
bibechana-80853	230	16	s.	s.	PROPN
bibechana-80853	230	17	schmitt	schmitt	PROPN
bibechana-80853	230	18	.	.	PUNCT
bibechana-80853	231	1	an	an	DET
bibechana-80853	231	2	alternative	alternative	ADJ
bibechana-80853	231	3	method	method	NOUN
bibechana-80853	231	4	for	for	ADP
bibechana-80853	231	5	the	the	DET
bibechana-80853	231	6	evaluation	evaluation	NOUN
bibechana-80853	231	7	of	of	ADP
bibechana-80853	231	8	docking	docking	NOUN
bibechana-80853	231	9	performance	performance	NOUN
bibechana-80853	231	10	:	:	PUNCT
bibechana-80853	231	11	rsr	rsr	NOUN
bibechana-80853	231	12	vs	vs	ADP
bibechana-80853	231	13	rmsd	rmsd	PROPN
bibechana-80853	231	14	.	.	PUNCT
bibechana-80853	232	1	journal	journal	PROPN
bibechana-80853	232	2	of	of	ADP
bibechana-80853	232	3	chemical	chemical	ADJ
bibechana-80853	232	4	information	information	NOUN
bibechana-80853	232	5	and	and	CCONJ
bibechana-80853	232	6	modeling	modeling	NOUN
bibechana-80853	232	7	,	,	PUNCT
bibechana-80853	232	8	48(7):1411–1422	48(7):1411–1422	NOUN
bibechana-80853	232	9	,	,	PUNCT
bibechana-80853	232	10	2008	2008	NUM
bibechana-80853	232	11	.	.	PUNCT
bibechana-80853	233	1	[	[	X
bibechana-80853	233	2	30	30	NUM
bibechana-80853	233	3	]	]	X
bibechana-80853	233	4	i.	i.	PROPN
bibechana-80853	233	5	a.	a.	PROPN
bibechana-80853	233	6	guedes	guedes	PROPN
bibechana-80853	233	7	et	et	PROPN
bibechana-80853	233	8	al	al	PROPN
bibechana-80853	233	9	.	.	PROPN
bibechana-80853	233	10	dockthor	dockthor	PROPN
bibechana-80853	233	11	-	-	PUNCT
bibechana-80853	233	12	vs	vs	ADP
bibechana-80853	233	13	:	:	PUNCT
bibechana-80853	233	14	a	a	DET
bibechana-80853	233	15	free	free	ADJ
bibechana-80853	233	16	platform	platform	NOUN
bibechana-80853	233	17	for	for	ADP
bibechana-80853	233	18	receptor	receptor	NOUN
bibechana-80853	233	19	-	-	PUNCT
bibechana-80853	233	20	ligand	ligand	ADJ
bibechana-80853	233	21	virtual	virtual	ADJ
bibechana-80853	233	22	screening	screening	NOUN
bibechana-80853	233	23	.	.	PUNCT
bibechana-80853	234	1	journal	journal	NOUN
bibechana-80853	234	2	of	of	ADP
bibechana-80853	234	3	molecular	molecular	ADJ
bibechana-80853	234	4	biology	biology	NOUN
bibechana-80853	234	5	,	,	PUNCT
bibechana-80853	234	6	page	page	NOUN
bibechana-80853	234	7	168548	168548	NUM
bibechana-80853	234	8	,	,	PUNCT
bibechana-80853	234	9	march	march	PROPN
bibechana-80853	234	10	2024	2024	NUM
bibechana-80853	234	11	.	.	PUNCT
bibechana-80853	235	1	[	[	X
bibechana-80853	235	2	31	31	NUM
bibechana-80853	235	3	]	]	PUNCT
bibechana-80853	235	4	j.	j.	PROPN
bibechana-80853	235	5	adhikari	adhikari	PROPN
bibechana-80853	235	6	subin	subin	PROPN
bibechana-80853	235	7	and	and	CCONJ
bibechana-80853	235	8	r.	r.	PROPN
bibechana-80853	235	9	l.	l.	PROPN
bibechana-80853	235	10	s.	s.	PROPN
bibechana-80853	235	11	shrestha	shrestha	PROPN
bibechana-80853	235	12	.	.	PUNCT
bibechana-80853	236	1	computational	computational	ADJ
bibechana-80853	236	2	assessment	assessment	NOUN
bibechana-80853	236	3	of	of	ADP
bibechana-80853	236	4	the	the	DET
bibechana-80853	236	5	phytochemicals	phytochemical	NOUN
bibechana-80853	236	6	of	of	ADP
bibechana-80853	236	7	panax	panax	PROPN
bibechana-80853	236	8	ginseng	ginseng	PROPN
bibechana-80853	236	9	c.a	c.a	PROPN
bibechana-80853	236	10	.	.	PROPN
bibechana-80853	236	11	meyer	meyer	PROPN
bibechana-80853	236	12	against	against	ADP
bibechana-80853	236	13	dopamine	dopamine	NOUN
bibechana-80853	236	14	receptor	receptor	NOUN
bibechana-80853	236	15	d1	d1	PROPN
bibechana-80853	236	16	for	for	ADP
bibechana-80853	236	17	early	early	PROPN
bibechana-80853	236	18	huntington	huntington	PROPN
bibechana-80853	236	19	’s	’s	PART
bibechana-80853	236	20	disease	disease	NOUN
bibechana-80853	236	21	prophylactics	prophylactic	NOUN
bibechana-80853	236	22	.	.	PUNCT
bibechana-80853	237	1	cell	cell	NOUN
bibechana-80853	237	2	biochemistry	biochemistry	NOUN
bibechana-80853	237	3	and	and	CCONJ
bibechana-80853	237	4	biophysics	biophysic	NOUN
bibechana-80853	237	5	,	,	PUNCT
bibechana-80853	237	6	july	july	PROPN
bibechana-80853	237	7	2024	2024	NUM
bibechana-80853	237	8	.	.	PUNCT
bibechana-80853	238	1	[	[	X
bibechana-80853	238	2	32	32	NUM
bibechana-80853	238	3	]	]	PUNCT
bibechana-80853	238	4	m.	m.	PROPN
bibechana-80853	238	5	k.	k.	PROPN
bibechana-80853	238	6	gilson	gilson	PROPN
bibechana-80853	238	7	and	and	CCONJ
bibechana-80853	238	8	h.-x	h.-x	NOUN
bibechana-80853	238	9	.	.	PUNCT
bibechana-80853	239	1	zhou	zhou	PROPN
bibechana-80853	239	2	.	.	PUNCT
bibechana-80853	240	1	calculation	calculation	NOUN
bibechana-80853	240	2	of	of	ADP
bibechana-80853	240	3	protein	protein	NOUN
bibechana-80853	240	4	-	-	PUNCT
bibechana-80853	240	5	ligand	ligand	ADJ
bibechana-80853	240	6	binding	bind	VERB
bibechana-80853	240	7	affinities	affinity	NOUN
bibechana-80853	240	8	.	.	PUNCT
bibechana-80853	241	1	annual	annual	ADJ
bibechana-80853	241	2	review	review	NOUN
bibechana-80853	241	3	of	of	ADP
bibechana-80853	241	4	biophysics	biophysic	NOUN
bibechana-80853	241	5	and	and	CCONJ
bibechana-80853	241	6	biomolecular	biomolecular	ADJ
bibechana-80853	241	7	structure	structure	NOUN
bibechana-80853	241	8	,	,	PUNCT
bibechana-80853	241	9	36(1):21–42	36(1):21–42	NUM
bibechana-80853	241	10	,	,	PUNCT
bibechana-80853	241	11	2007	2007	NUM
bibechana-80853	241	12	.	.	PUNCT
bibechana-80853	242	1	[	[	X
bibechana-80853	242	2	33	33	NUM
bibechana-80853	242	3	]	]	PUNCT
bibechana-80853	242	4	m.	m.	NOUN
bibechana-80853	242	5	poudel	poudel	PROPN
bibechana-80853	242	6	et	et	PROPN
bibechana-80853	242	7	al	al	PROPN
bibechana-80853	242	8	.	.	PUNCT
bibechana-80853	242	9	exploration	exploration	NOUN
bibechana-80853	242	10	of	of	ADP
bibechana-80853	242	11	antioxidant	antioxidant	ADJ
bibechana-80853	242	12	,	,	PUNCT
bibechana-80853	242	13	antibacterial	antibacterial	ADJ
bibechana-80853	242	14	,	,	PUNCT
bibechana-80853	242	15	and	and	CCONJ
bibechana-80853	242	16	alpha	alpha	NOUN
bibechana-80853	242	17	-	-	PUNCT
bibechana-80853	242	18	glucosidase	glucosidase	NOUN
bibechana-80853	242	19	inhibition	inhibition	NOUN
bibechana-80853	242	20	potential	potential	NOUN
bibechana-80853	242	21	of	of	ADP
bibechana-80853	242	22	cirsium	cirsium	PROPN
bibechana-80853	242	23	verutum	verutum	NOUN
bibechana-80853	242	24	(	(	PUNCT
bibechana-80853	242	25	d.	d.	PROPN
bibechana-80853	242	26	don	don	PROPN
bibechana-80853	242	27	)	)	PUNCT
bibechana-80853	243	1	spreng	spreng	PROPN
bibechana-80853	243	2	extracts	extract	NOUN
bibechana-80853	243	3	:	:	PUNCT
bibechana-80853	243	4	in	in	ADP
bibechana-80853	243	5	vitro	vitro	X
bibechana-80853	243	6	and	and	CCONJ
bibechana-80853	243	7	in	in	ADP
bibechana-80853	243	8	silico	silico	NOUN
bibechana-80853	243	9	approach	approach	NOUN
bibechana-80853	243	10	.	.	PUNCT
bibechana-80853	244	1	asian	asian	ADJ
bibechana-80853	244	2	journal	journal	PROPN
bibechana-80853	244	3	of	of	ADP
bibechana-80853	244	4	applied	apply	VERB
bibechana-80853	244	5	chemistry	chemistry	NOUN
bibechana-80853	244	6	research	research	NOUN
bibechana-80853	244	7	,	,	PUNCT
bibechana-80853	244	8	15(4):55–70	15(4):55–70	NUM
bibechana-80853	244	9	,	,	PUNCT
bibechana-80853	244	10	2024	2024	NUM
bibechana-80853	244	11	.	.	PUNCT
bibechana-80853	245	1	[	[	X
bibechana-80853	245	2	34	34	NUM
bibechana-80853	245	3	]	]	X
bibechana-80853	245	4	r.	r.	PROPN
bibechana-80853	245	5	p.	p.	PROPN
bibechana-80853	245	6	singh	singh	PROPN
bibechana-80853	245	7	and	and	CCONJ
bibechana-80853	245	8	a.	a.	PROPN
bibechana-80853	245	9	k.	k.	PROPN
bibechana-80853	245	10	pattnaik	pattnaik	PROPN
bibechana-80853	245	11	.	.	PUNCT
bibechana-80853	246	1	scientific	scientific	ADJ
bibechana-80853	246	2	insights	insight	NOUN
bibechana-80853	246	3	into	into	ADP
bibechana-80853	246	4	hyperlipidemia	hyperlipidemia	NOUN
bibechana-80853	246	5	mitigation	mitigation	NOUN
bibechana-80853	246	6	:	:	PUNCT
bibechana-80853	246	7	a	a	DET
bibechana-80853	246	8	profound	profound	ADJ
bibechana-80853	246	9	examination	examination	NOUN
bibechana-80853	246	10	of	of	ADP
bibechana-80853	246	11	isolated	isolate	VERB
bibechana-80853	246	12	bioactive	bioactive	ADJ
bibechana-80853	246	13	fractions	fraction	NOUN
bibechana-80853	246	14	of	of	ADP
bibechana-80853	246	15	kalanchoe	kalanchoe	NOUN
bibechana-80853	246	16	pinnata	pinnata	NOUN
bibechana-80853	246	17	leaves	leave	NOUN
bibechana-80853	246	18	and	and	CCONJ
bibechana-80853	246	19	their	their	PRON
bibechana-80853	246	20	therapeutic	therapeutic	ADJ
bibechana-80853	246	21	implications	implication	NOUN
bibechana-80853	246	22	using	use	VERB
bibechana-80853	246	23	in	in	ADP
bibechana-80853	246	24	vitro	vitro	NOUN
bibechana-80853	246	25	,	,	PUNCT
bibechana-80853	246	26	in	in	ADP
bibechana-80853	246	27	vivo	vivo	NOUN
bibechana-80853	246	28	,	,	PUNCT
bibechana-80853	246	29	and	and	CCONJ
bibechana-80853	246	30	in	in	ADP
bibechana-80853	246	31	silico	silico	NOUN
bibechana-80853	246	32	study	study	NOUN
bibechana-80853	246	33	.	.	PUNCT
bibechana-80853	247	1	pharmacognosy	pharmacognosy	PROPN
bibechana-80853	247	2	magazine	magazine	PROPN
bibechana-80853	247	3	,	,	PUNCT
bibechana-80853	247	4	pages	page	NOUN
bibechana-80853	247	5	1–14	1–14	PROPN
bibechana-80853	247	6	,	,	PUNCT
bibechana-80853	247	7	2024	2024	NUM
bibechana-80853	247	8	.	.	PUNCT
bibechana-80853	248	1	[	[	X
bibechana-80853	248	2	35	35	NUM
bibechana-80853	248	3	]	]	X
bibechana-80853	248	4	d.	d.	PROPN
bibechana-80853	248	5	ramírez	ramírez	PROPN
bibechana-80853	248	6	and	and	CCONJ
bibechana-80853	248	7	j.	j.	PROPN
bibechana-80853	248	8	caballero	caballero	PROPN
bibechana-80853	248	9	.	.	PROPN
bibechana-80853	248	10	is	be	AUX
bibechana-80853	248	11	it	it	PRON
bibechana-80853	248	12	reliable	reliable	ADJ
bibechana-80853	248	13	to	to	PART
bibechana-80853	248	14	take	take	VERB
bibechana-80853	248	15	the	the	DET
bibechana-80853	248	16	molecular	molecular	ADJ
bibechana-80853	248	17	docking	docking	NOUN
bibechana-80853	248	18	top	top	ADJ
bibechana-80853	248	19	scoring	scoring	NOUN
bibechana-80853	248	20	position	position	NOUN
bibechana-80853	248	21	as	as	ADP
bibechana-80853	248	22	the	the	DET
bibechana-80853	248	23	best	good	ADJ
bibechana-80853	248	24	solution	solution	NOUN
bibechana-80853	248	25	without	without	ADP
bibechana-80853	248	26	considering	consider	VERB
bibechana-80853	248	27	available	available	ADJ
bibechana-80853	248	28	structural	structural	ADJ
bibechana-80853	248	29	data	datum	NOUN
bibechana-80853	248	30	?	?	PUNCT
bibechana-80853	249	1	molecules	molecule	NOUN
bibechana-80853	249	2	,	,	PUNCT
bibechana-80853	249	3	23(5):1038	23(5):1038	NUM
bibechana-80853	249	4	,	,	PUNCT
bibechana-80853	249	5	2018	2018	NUM
bibechana-80853	249	6	.	.	PUNCT
bibechana-80853	250	1	[	[	X
bibechana-80853	250	2	36	36	NUM
bibechana-80853	250	3	]	]	X
bibechana-80853	250	4	v.	v.	ADP
bibechana-80853	250	5	n.	n.	PROPN
bibechana-80853	250	6	maiorov	maiorov	PROPN
bibechana-80853	250	7	and	and	CCONJ
bibechana-80853	250	8	g.	g.	PROPN
bibechana-80853	250	9	m.	m.	PROPN
bibechana-80853	250	10	crippen	crippen	PROPN
bibechana-80853	250	11	.	.	PUNCT
bibechana-80853	251	1	significance	significance	NOUN
bibechana-80853	251	2	of	of	ADP
bibechana-80853	251	3	root	root	NOUN
bibechana-80853	251	4	-	-	PUNCT
bibechana-80853	251	5	mean	mean	ADJ
bibechana-80853	251	6	-	-	PUNCT
bibechana-80853	251	7	square	square	NOUN
bibechana-80853	251	8	deviation	deviation	NOUN
bibechana-80853	251	9	in	in	ADP
bibechana-80853	251	10	comparing	compare	VERB
bibechana-80853	251	11	three	three	NUM
bibechana-80853	251	12	-	-	PUNCT
bibechana-80853	251	13	dimensional	dimensional	ADJ
bibechana-80853	251	14	structures	structure	NOUN
bibechana-80853	251	15	of	of	ADP
bibechana-80853	251	16	globular	globular	ADJ
bibechana-80853	251	17	proteins	protein	NOUN
bibechana-80853	251	18	.	.	PUNCT
bibechana-80853	252	1	journal	journal	NOUN
bibechana-80853	252	2	of	of	ADP
bibechana-80853	252	3	molecular	molecular	ADJ
bibechana-80853	252	4	biology	biology	NOUN
bibechana-80853	252	5	,	,	PUNCT
bibechana-80853	252	6	235(2):625–634	235(2):625–634	PROPN
bibechana-80853	252	7	,	,	PUNCT
bibechana-80853	252	8	1994	1994	NUM
bibechana-80853	252	9	.	.	PUNCT
bibechana-80853	253	1	[	[	X
bibechana-80853	253	2	37	37	NUM
bibechana-80853	253	3	]	]	PUNCT
bibechana-80853	253	4	m.	m.	PROPN
bibechana-80853	253	5	f.	f.	PROPN
bibechana-80853	253	6	adasme	adasme	PROPN
bibechana-80853	253	7	et	et	PROPN
bibechana-80853	253	8	al	al	PROPN
bibechana-80853	253	9	.	.	PROPN
bibechana-80853	253	10	plip	plip	PROPN
bibechana-80853	253	11	2021	2021	NUM
bibechana-80853	253	12	:	:	PUNCT
bibechana-80853	253	13	expanding	expand	VERB
bibechana-80853	253	14	the	the	DET
bibechana-80853	253	15	scope	scope	NOUN
bibechana-80853	253	16	of	of	ADP
bibechana-80853	253	17	the	the	DET
bibechana-80853	253	18	protein	protein	NOUN
bibechana-80853	253	19	-	-	PUNCT
bibechana-80853	253	20	ligand	ligand	NOUN
bibechana-80853	253	21	interaction	interaction	NOUN
bibechana-80853	253	22	profiler	profiler	NOUN
bibechana-80853	253	23	to	to	ADP
bibechana-80853	253	24	dna	dna	PROPN
bibechana-80853	253	25	and	and	CCONJ
bibechana-80853	253	26	rna	rna	PROPN
bibechana-80853	253	27	.	.	PUNCT
bibechana-80853	254	1	nucleic	nucleic	ADJ
bibechana-80853	254	2	acids	acid	NOUN
bibechana-80853	254	3	research	research	NOUN
bibechana-80853	254	4	,	,	PUNCT
bibechana-80853	254	5	49(w1):w530	49(w1):w530	NUM
bibechana-80853	254	6	–	–	PUNCT
bibechana-80853	254	7	w534	w534	NUM
bibechana-80853	254	8	,	,	PUNCT
bibechana-80853	254	9	2021	2021	NUM
bibechana-80853	254	10	.	.	PUNCT
bibechana-80853	255	1	[	[	X
bibechana-80853	255	2	38	38	NUM
bibechana-80853	255	3	]	]	PUNCT
bibechana-80853	255	4	b.	b.	PROPN
bibechana-80853	255	5	q.	q.	PROPN
bibechana-80853	255	6	wei	wei	PROPN
bibechana-80853	255	7	,	,	PUNCT
bibechana-80853	255	8	w.	w.	PROPN
bibechana-80853	255	9	a.	a.	PROPN
bibechana-80853	255	10	baase	baase	PROPN
bibechana-80853	255	11	,	,	PUNCT
bibechana-80853	255	12	l.	l.	PROPN
bibechana-80853	255	13	h.	h.	PROPN
bibechana-80853	255	14	weaver	weaver	PROPN
bibechana-80853	255	15	,	,	PUNCT
bibechana-80853	255	16	b.	b.	PROPN
bibechana-80853	255	17	w.	w.	PROPN
bibechana-80853	255	18	matthews	matthews	PROPN
bibechana-80853	255	19	,	,	PUNCT
bibechana-80853	255	20	and	and	CCONJ
bibechana-80853	255	21	b.	b.	PROPN
bibechana-80853	255	22	k.	k.	PROPN
bibechana-80853	255	23	shoichet	shoichet	PROPN
bibechana-80853	255	24	.	.	PUNCT
bibechana-80853	256	1	a	a	DET
bibechana-80853	256	2	model	model	NOUN
bibechana-80853	256	3	binding	bind	VERB
bibechana-80853	256	4	site	site	NOUN
bibechana-80853	256	5	for	for	ADP
bibechana-80853	256	6	testing	test	VERB
bibechana-80853	256	7	scoring	scoring	NOUN
bibechana-80853	256	8	functions	function	NOUN
bibechana-80853	256	9	in	in	ADP
bibechana-80853	256	10	molecular	molecular	ADJ
bibechana-80853	256	11	docking	docking	NOUN
bibechana-80853	256	12	.	.	PUNCT
bibechana-80853	257	1	journal	journal	NOUN
bibechana-80853	257	2	of	of	ADP
bibechana-80853	257	3	molecular	molecular	ADJ
bibechana-80853	257	4	biology	biology	NOUN
bibechana-80853	257	5	,	,	PUNCT
bibechana-80853	257	6	322(2):339–355	322(2):339–355	NUM
bibechana-80853	257	7	,	,	PUNCT
bibechana-80853	257	8	2002	2002	NUM
bibechana-80853	257	9	.	.	PUNCT
bibechana-80853	258	1	[	[	X
bibechana-80853	258	2	39	39	NUM
bibechana-80853	258	3	]	]	PUNCT
bibechana-80853	258	4	a.	a.	NOUN
bibechana-80853	258	5	rausell	rausell	PROPN
bibechana-80853	258	6	,	,	PUNCT
bibechana-80853	258	7	d.	d.	PROPN
bibechana-80853	258	8	juan	juan	PROPN
bibechana-80853	258	9	,	,	PUNCT
bibechana-80853	258	10	f.	f.	PROPN
bibechana-80853	258	11	pazos	pazos	PROPN
bibechana-80853	258	12	,	,	PUNCT
bibechana-80853	258	13	and	and	CCONJ
bibechana-80853	258	14	a.	a.	NOUN
bibechana-80853	258	15	valencia	valencia	PROPN
bibechana-80853	258	16	.	.	PUNCT
bibechana-80853	259	1	protein	protein	NOUN
bibechana-80853	259	2	interactions	interaction	NOUN
bibechana-80853	259	3	and	and	CCONJ
bibechana-80853	259	4	ligand	ligand	ADJ
bibechana-80853	259	5	binding	bind	VERB
bibechana-80853	259	6	:	:	PUNCT
bibechana-80853	259	7	from	from	ADP
bibechana-80853	259	8	protein	protein	NOUN
bibechana-80853	259	9	subfamilies	subfamily	NOUN
bibechana-80853	259	10	to	to	ADP
bibechana-80853	259	11	functional	functional	ADJ
bibechana-80853	259	12	specificity	specificity	NOUN
bibechana-80853	259	13	.	.	PUNCT
bibechana-80853	260	1	proceedings	proceeding	NOUN
bibechana-80853	260	2	of	of	ADP
bibechana-80853	260	3	the	the	DET
bibechana-80853	260	4	national	national	PROPN
bibechana-80853	260	5	academy	academy	PROPN
bibechana-80853	260	6	of	of	ADP
bibechana-80853	260	7	sciences	sciences	PROPN
bibechana-80853	260	8	usa	usa	PROPN
bibechana-80853	260	9	,	,	PUNCT
bibechana-80853	260	10	107(5):1995–2000	107(5):1995–2000	PROPN
bibechana-80853	260	11	,	,	PUNCT
bibechana-80853	260	12	2010	2010	NUM
bibechana-80853	260	13	.	.	PUNCT
bibechana-80853	261	1	[	[	X
bibechana-80853	261	2	40	40	NUM
bibechana-80853	261	3	]	]	PUNCT
bibechana-80853	261	4	m.	m.	PROPN
bibechana-80853	261	5	l.	l.	PROPN
bibechana-80853	261	6	verdonk	verdonk	PROPN
bibechana-80853	261	7	,	,	PUNCT
bibechana-80853	261	8	p.	p.	PROPN
bibechana-80853	261	9	n.	n.	PROPN
bibechana-80853	261	10	mortenson	mortenson	PROPN
bibechana-80853	261	11	,	,	PUNCT
bibechana-80853	261	12	r.	r.	PROPN
bibechana-80853	261	13	j.	j.	PROPN
bibechana-80853	261	14	hall	hall	PROPN
bibechana-80853	261	15	,	,	PUNCT
bibechana-80853	261	16	m.	m.	PROPN
bibechana-80853	261	17	j.	j.	PROPN
bibechana-80853	261	18	hartshorn	hartshorn	PROPN
bibechana-80853	261	19	,	,	PUNCT
bibechana-80853	261	20	and	and	CCONJ
bibechana-80853	261	21	c.	c.	PROPN
bibechana-80853	261	22	w.	w.	PROPN
bibechana-80853	261	23	murray	murray	PROPN
bibechana-80853	261	24	.	.	PUNCT
bibechana-80853	262	1	proteinligand	proteinligand	ADJ
bibechana-80853	262	2	docking	docking	NOUN
bibechana-80853	262	3	against	against	ADP
bibechana-80853	262	4	non	non	ADJ
bibechana-80853	262	5	-	-	ADJ
bibechana-80853	262	6	native	native	ADJ
bibechana-80853	262	7	protein	protein	NOUN
bibechana-80853	262	8	conformers	conformer	NOUN
bibechana-80853	262	9	.	.	PUNCT
bibechana-80853	263	1	journal	journal	PROPN
bibechana-80853	263	2	of	of	ADP
bibechana-80853	263	3	chemical	chemical	ADJ
bibechana-80853	263	4	information	information	NOUN
bibechana-80853	263	5	and	and	CCONJ
bibechana-80853	263	6	modeling	modeling	NOUN
bibechana-80853	263	7	,	,	PUNCT
bibechana-80853	263	8	48(11):2214–2225	48(11):2214–2225	NUM
bibechana-80853	263	9	,	,	PUNCT
bibechana-80853	263	10	2008	2008	NUM
bibechana-80853	263	11	.	.	PUNCT
bibechana-80853	264	1	[	[	X
bibechana-80853	264	2	41	41	NUM
bibechana-80853	264	3	]	]	X
bibechana-80853	264	4	r.	r.	NOUN
bibechana-80853	264	5	jagannathan	jagannathan	PROPN
bibechana-80853	264	6	.	.	PUNCT
bibechana-80853	265	1	characterization	characterization	NOUN
bibechana-80853	265	2	of	of	ADP
bibechana-80853	265	3	drug	drug	NOUN
bibechana-80853	265	4	-	-	PUNCT
bibechana-80853	265	5	like	like	ADJ
bibechana-80853	265	6	chemical	chemical	NOUN
bibechana-80853	265	7	space	space	NOUN
bibechana-80853	265	8	for	for	ADP
bibechana-80853	265	9	cytotoxic	cytotoxic	ADJ
bibechana-80853	265	10	marine	marine	ADJ
bibechana-80853	265	11	metabolites	metabolite	NOUN
bibechana-80853	265	12	using	use	VERB
bibechana-80853	265	13	multivariate	multivariate	NOUN
bibechana-80853	265	14	methods	method	NOUN
bibechana-80853	265	15	.	.	PUNCT
bibechana-80853	266	1	acs	acs	PROPN
bibechana-80853	266	2	omega	omega	NOUN
bibechana-80853	266	3	,	,	PUNCT
bibechana-80853	266	4	4:5402–5411	4:5402–5411	NUM
bibechana-80853	266	5	,	,	PUNCT
bibechana-80853	266	6	2019	2019	NUM
bibechana-80853	266	7	.	.	PUNCT
bibechana-80853	267	1	[	[	X
bibechana-80853	267	2	42	42	NUM
bibechana-80853	267	3	]	]	PUNCT
bibechana-80853	267	4	a.	a.	PROPN
bibechana-80853	267	5	daina	daina	PROPN
bibechana-80853	267	6	and	and	CCONJ
bibechana-80853	267	7	v.	v.	ADP
bibechana-80853	267	8	zoete	zoete	NOUN
bibechana-80853	267	9	.	.	PUNCT
bibechana-80853	268	1	a	a	DET
bibechana-80853	268	2	boiled	boil	VERB
bibechana-80853	268	3	-	-	PUNCT
bibechana-80853	268	4	egg	egg	NOUN
bibechana-80853	268	5	to	to	PART
bibechana-80853	268	6	predict	predict	VERB
bibechana-80853	268	7	gastrointestinal	gastrointestinal	ADJ
bibechana-80853	268	8	absorption	absorption	NOUN
bibechana-80853	268	9	and	and	CCONJ
bibechana-80853	268	10	brain	brain	NOUN
bibechana-80853	268	11	penetration	penetration	NOUN
bibechana-80853	268	12	of	of	ADP
bibechana-80853	268	13	small	small	ADJ
bibechana-80853	268	14	molecules	molecule	NOUN
bibechana-80853	268	15	.	.	PUNCT
bibechana-80853	269	1	chemmedchem	chemmedchem	PROPN
bibechana-80853	269	2	,	,	PUNCT
bibechana-80853	269	3	11(11):1117–1121	11(11):1117–1121	NUM
bibechana-80853	269	4	,	,	PUNCT
bibechana-80853	269	5	2016	2016	NUM
bibechana-80853	269	6	.	.	PUNCT
bibechana-80853	270	1	[	[	X
bibechana-80853	270	2	43	43	NUM
bibechana-80853	270	3	]	]	PUNCT
bibechana-80853	270	4	s.	s.	PROPN
bibechana-80853	270	5	y.	y.	PROPN
bibechana-80853	270	6	m.	m.	PROPN
bibechana-80853	270	7	lim	lim	PROPN
bibechana-80853	270	8	,	,	PUNCT
bibechana-80853	270	9	j.	j.	PROPN
bibechana-80853	270	10	s.	s.	PROPN
bibechana-80853	270	11	e.	e.	PROPN
bibechana-80853	270	12	loo	loo	PROPN
bibechana-80853	270	13	,	,	PUNCT
bibechana-80853	270	14	m.	m.	PROPN
bibechana-80853	270	15	alshagga	alshagga	PROPN
bibechana-80853	270	16	,	,	PUNCT
bibechana-80853	270	17	m.	m.	NOUN
bibechana-80853	270	18	a.	a.	PROPN
bibechana-80853	270	19	alshawsh	alshawsh	PROPN
bibechana-80853	270	20	,	,	PUNCT
bibechana-80853	270	21	c.	c.	PROPN
bibechana-80853	270	22	e.	e.	PROPN
bibechana-80853	270	23	ong	ong	PROPN
bibechana-80853	270	24	,	,	PUNCT
bibechana-80853	270	25	and	and	CCONJ
bibechana-80853	270	26	y.	y.	PROPN
bibechana-80853	270	27	pan	pan	PROPN
bibechana-80853	270	28	.	.	PROPN
bibechana-80853	271	1	in	in	ADP
bibechana-80853	271	2	vitro	vitro	X
bibechana-80853	271	3	and	and	CCONJ
bibechana-80853	271	4	in	in	ADP
bibechana-80853	271	5	silico	silico	NOUN
bibechana-80853	271	6	studies	study	NOUN
bibechana-80853	271	7	of	of	ADP
bibechana-80853	271	8	interactions	interaction	NOUN
bibechana-80853	271	9	of	of	ADP
bibechana-80853	271	10	cathinone	cathinone	NOUN
bibechana-80853	271	11	with	with	ADP
bibechana-80853	271	12	human	human	ADJ
bibechana-80853	271	13	recombinant	recombinant	ADJ
bibechana-80853	271	14	cytochrome	cytochrome	ADJ
bibechana-80853	271	15	p450	p450	NUM
bibechana-80853	271	16	enzymes	enzyme	NOUN
bibechana-80853	271	17	.	.	PUNCT
bibechana-80853	272	1	toxicology	toxicology	NOUN
bibechana-80853	272	2	reports	report	NOUN
bibechana-80853	272	3	,	,	PUNCT
bibechana-80853	272	4	9:759–768	9:759–768	NOUN
bibechana-80853	272	5	,	,	PUNCT
bibechana-80853	272	6	2022	2022	NUM
bibechana-80853	272	7	.	.	PUNCT
bibechana-80853	273	1	[	[	X
bibechana-80853	273	2	44	44	NUM
bibechana-80853	273	3	]	]	PUNCT
bibechana-80853	273	4	j.	j.	PROPN
bibechana-80853	273	5	x.	x.	PROPN
bibechana-80853	273	6	qiu	qiu	PROPN
bibechana-80853	273	7	,	,	PUNCT
bibechana-80853	273	8	z.	z.	PROPN
bibechana-80853	273	9	w.	w.	PROPN
bibechana-80853	273	10	zhou	zhou	PROPN
bibechana-80853	273	11	,	,	PUNCT
bibechana-80853	273	12	z.	z.	PROPN
bibechana-80853	273	13	x.	x.	NOUN
bibechana-80853	274	1	he	he	PRON
bibechana-80853	274	2	,	,	PUNCT
bibechana-80853	274	3	x.	x.	PROPN
bibechana-80853	274	4	zhang	zhang	PROPN
bibechana-80853	274	5	,	,	PUNCT
bibechana-80853	274	6	s.	s.	PROPN
bibechana-80853	274	7	f.	f.	PROPN
bibechana-80853	274	8	zhou	zhou	PROPN
bibechana-80853	274	9	,	,	PUNCT
bibechana-80853	274	10	and	and	CCONJ
bibechana-80853	274	11	s.	s.	PROPN
bibechana-80853	274	12	zhu	zhu	PROPN
bibechana-80853	274	13	.	.	PUNCT
bibechana-80853	275	1	estimation	estimation	NOUN
bibechana-80853	275	2	of	of	ADP
bibechana-80853	275	3	the	the	DET
bibechana-80853	275	4	binding	bind	VERB
bibechana-80853	275	5	modes	mode	NOUN
bibechana-80853	275	6	with	with	ADP
bibechana-80853	275	7	important	important	ADJ
bibechana-80853	275	8	human	human	ADJ
bibechana-80853	275	9	cytochrome	cytochrome	NOUN
bibechana-80853	275	10	p450	p450	NUM
bibechana-80853	275	11	enzymes	enzyme	NOUN
bibechana-80853	275	12	,	,	PUNCT
bibechana-80853	275	13	drug	drug	NOUN
bibechana-80853	275	14	interaction	interaction	NOUN
bibechana-80853	275	15	potential	potential	NOUN
bibechana-80853	275	16	,	,	PUNCT
bibechana-80853	275	17	pharmacokinetics	pharmacokinetic	NOUN
bibechana-80853	275	18	,	,	PUNCT
bibechana-80853	275	19	and	and	CCONJ
bibechana-80853	275	20	hepatotoxicity	hepatotoxicity	NOUN
bibechana-80853	275	21	of	of	ADP
bibechana-80853	275	22	ginger	ginger	NOUN
bibechana-80853	275	23	components	component	NOUN
bibechana-80853	275	24	using	use	VERB
bibechana-80853	275	25	molecular	molecular	ADJ
bibechana-80853	275	26	docking	docking	NOUN
bibechana-80853	275	27	,	,	PUNCT
bibechana-80853	275	28	computational	computational	ADJ
bibechana-80853	275	29	,	,	PUNCT
bibechana-80853	275	30	and	and	CCONJ
bibechana-80853	275	31	pharmacokinetic	pharmacokinetic	ADJ
bibechana-80853	275	32	modeling	modeling	NOUN
bibechana-80853	275	33	studies	study	NOUN
bibechana-80853	275	34	.	.	PUNCT
bibechana-80853	276	1	drug	drug	NOUN
bibechana-80853	276	2	design	design	PROPN
bibechana-80853	276	3	,	,	PUNCT
bibechana-80853	276	4	development	development	NOUN
bibechana-80853	276	5	and	and	CCONJ
bibechana-80853	276	6	therapy	therapy	NOUN
bibechana-80853	276	7	,	,	PUNCT
bibechana-80853	276	8	9:841–866	9:841–866	PROPN
bibechana-80853	276	9	,	,	PUNCT
bibechana-80853	276	10	2015	2015	NUM
bibechana-80853	276	11	.	.	PUNCT
bibechana-80853	277	1	introduction	introduction	NOUN
bibechana-80853	277	2	methodology	methodology	NOUN
bibechana-80853	277	3	ligand	ligand	NOUN
bibechana-80853	277	4	search	search	NOUN
bibechana-80853	277	5	protein	protein	NOUN
bibechana-80853	277	6	target	target	NOUN
bibechana-80853	277	7	search	search	NOUN
bibechana-80853	277	8	ligand	ligand	NOUN
bibechana-80853	277	9	optimization	optimization	NOUN
bibechana-80853	277	10	protein	protein	NOUN
bibechana-80853	277	11	structure	structure	NOUN
bibechana-80853	277	12	optimization	optimization	NOUN
bibechana-80853	277	13	molecular	molecular	ADJ
bibechana-80853	277	14	docking	docking	NOUN
bibechana-80853	277	15	calculations	calculation	NOUN
bibechana-80853	277	16	protocol	protocol	NOUN
bibechana-80853	277	17	validation	validation	NOUN
bibechana-80853	277	18	via	via	ADP
bibechana-80853	277	19	rmsd	rmsd	ADJ
bibechana-80853	277	20	calculation	calculation	NOUN
bibechana-80853	277	21	protein	protein	NOUN
bibechana-80853	277	22	-	-	PUNCT
bibechana-80853	277	23	ligand	ligand	ADJ
bibechana-80853	277	24	interactions	interaction	NOUN
bibechana-80853	277	25	admet	admet	NOUN
bibechana-80853	277	26	properties	property	NOUN
bibechana-80853	277	27	and	and	CCONJ
bibechana-80853	277	28	toxicity	toxicity	NOUN
bibechana-80853	277	29	class	class	NOUN
bibechana-80853	277	30	identification	identification	NOUN
bibechana-80853	277	31	results	result	NOUN
bibechana-80853	277	32	and	and	CCONJ
bibechana-80853	277	33	discussion	discussion	NOUN
bibechana-80853	277	34	molecular	molecular	ADJ
bibechana-80853	277	35	docking	docking	NOUN
bibechana-80853	277	36	protocol	protocol	NOUN
bibechana-80853	277	37	validation	validation	NOUN
bibechana-80853	277	38	binding	bind	VERB
bibechana-80853	277	39	affinity	affinity	NOUN
bibechana-80853	277	40	and	and	CCONJ
bibechana-80853	277	41	strength	strength	NOUN
bibechana-80853	277	42	of	of	ADP
bibechana-80853	277	43	interactions	interaction	NOUN
bibechana-80853	277	44	present	present	ADJ
bibechana-80853	277	45	in	in	ADP
bibechana-80853	277	46	the	the	DET
bibechana-80853	277	47	protein	protein	NOUN
bibechana-80853	277	48	-	-	PUNCT
bibechana-80853	277	49	ligand	ligand	NOUN
bibechana-80853	277	50	complexes	complex	NOUN
bibechana-80853	277	51	admet	admet	VERB
bibechana-80853	277	52	analysis	analysis	NOUN
bibechana-80853	277	53	conclusion	conclusion	NOUN