id	sid	tid	token	lemma	pos
bionys-498	1	1	jugović	jugović	PROPN
bionys-498	1	2	et	et	PROPN
bionys-498	1	3	al	al	PROPN
bionys-498	1	4	.	.	PROPN
bionys-498	1	5	2023	2023	NUM
bionys-498	1	6	,	,	PUNCT
bionys-498	1	7	biologica	biologica	PROPN
bionys-498	1	8	nyssana	nyssana	PROPN
bionys-498	1	9	14(1	14(1	NUM
bionys-498	1	10	)	)	PUNCT
bionys-498	1	11	14	14	NUM
bionys-498	1	12	(	(	PUNCT
bionys-498	1	13	1	1	NUM
bionys-498	1	14	)	)	PUNCT
bionys-498	1	15	june	june	PROPN
bionys-498	1	16	2023	2023	NUM
bionys-498	1	17	:	:	PUNCT
bionys-498	1	18	39	39	NUM
bionys-498	1	19	-	-	SYM
bionys-498	1	20	46	46	NUM
bionys-498	1	21	doi	doi	NOUN
bionys-498	1	22	:	:	PUNCT
bionys-498	1	23	10.5281	10.5281	NUM
bionys-498	1	24	/	/	SYM
bionys-498	1	25	zenodo.8027130	zenodo.8027130	PROPN
bionys-498	1	26	the	the	DET
bionys-498	1	27	frequency	frequency	NOUN
bionys-498	1	28	and	and	CCONJ
bionys-498	1	29	type	type	NOUN
bionys-498	1	30	of	of	ADP
bionys-498	1	31	mutations	mutation	NOUN
bionys-498	1	32	in	in	ADP
bionys-498	1	33	the	the	DET
bionys-498	1	34	egfr	egfr	ADJ
bionys-498	1	35	gene	gene	NOUN
bionys-498	1	36	of	of	ADP
bionys-498	1	37	colorectal	colorectal	ADJ
bionys-498	1	38	carcinoma	carcinoma	NOUN
bionys-498	1	39	patients	patient	NOUN
bionys-498	1	40	in	in	ADP
bionys-498	1	41	southeastern	southeastern	ADJ
bionys-498	1	42	serbia	serbia	PROPN
bionys-498	1	43	original	original	ADJ
bionys-498	1	44	article	article	NOUN
bionys-498	1	45	dragana	dragana	PROPN
bionys-498	1	46	jugović	jugović	PROPN
bionys-498	1	47	laboratory	laboratory	PROPN
bionys-498	1	48	for	for	ADP
bionys-498	1	49	immunology	immunology	NOUN
bionys-498	1	50	and	and	CCONJ
bionys-498	1	51	genetics	genetic	NOUN
bionys-498	1	52	,	,	PUNCT
bionys-498	1	53	center	center	NOUN
bionys-498	1	54	for	for	ADP
bionys-498	1	55	medical	medical	ADJ
bionys-498	1	56	and	and	CCONJ
bionys-498	1	57	clinical	clinical	ADJ
bionys-498	1	58	biochemistry	biochemistry	NOUN
bionys-498	1	59	,	,	PUNCT
bionys-498	1	60	university	university	NOUN
bionys-498	1	61	clinical	clinical	ADJ
bionys-498	1	62	center	center	NOUN
bionys-498	1	63	niš	niš	NOUN
bionys-498	1	64	,	,	PUNCT
bionys-498	1	65	serbia	serbia	PROPN
bionys-498	1	66	dragana.jugovic@live.com	dragana.jugovic@live.com	X
bionys-498	1	67	(	(	PUNCT
bionys-498	1	68	corresponding	corresponding	ADJ
bionys-498	1	69	author	author	NOUN
bionys-498	1	70	)	)	PUNCT
bionys-498	1	71	marija	marija	NOUN
bionys-498	1	72	vukelić	vukelić	NOUN
bionys-498	1	73	nikolić	nikolić	ADJ
bionys-498	1	74	faculty	faculty	NOUN
bionys-498	1	75	of	of	ADP
bionys-498	1	76	medicine	medicine	NOUN
bionys-498	1	77	,	,	PUNCT
bionys-498	1	78	research	research	NOUN
bionys-498	1	79	center	center	NOUN
bionys-498	1	80	for	for	ADP
bionys-498	1	81	biomedicine	biomedicine	NOUN
bionys-498	1	82	,	,	PUNCT
bionys-498	1	83	university	university	NOUN
bionys-498	1	84	of	of	ADP
bionys-498	1	85	niš	niš	PROPN
bionys-498	1	86	,	,	PUNCT
bionys-498	1	87	serbia	serbia	PROPN
bionys-498	1	88	višnja	višnja	VERB
bionys-498	1	89	madić	madić	PROPN
bionys-498	1	90	department	department	PROPN
bionys-498	1	91	of	of	ADP
bionys-498	1	92	biology	biology	NOUN
bionys-498	1	93	and	and	CCONJ
bionys-498	1	94	ecology	ecology	NOUN
bionys-498	1	95	,	,	PUNCT
bionys-498	1	96	faculty	faculty	NOUN
bionys-498	1	97	of	of	ADP
bionys-498	1	98	sciences	science	NOUN
bionys-498	1	99	and	and	CCONJ
bionys-498	1	100	mathematics	mathematic	NOUN
bionys-498	1	101	,	,	PUNCT
bionys-498	1	102	university	university	NOUN
bionys-498	1	103	of	of	ADP
bionys-498	1	104	niš	niš	PROPN
bionys-498	1	105	,	,	PUNCT
bionys-498	1	106	serbia	serbia	PROPN
bionys-498	1	107	aleksandar	aleksandar	PROPN
bionys-498	1	108	milićević	milićević	PROPN
bionys-498	1	109	pathology	pathology	PROPN
bionys-498	1	110	and	and	CCONJ
bionys-498	1	111	pathological	pathological	ADJ
bionys-498	1	112	anatomy	anatomy	NOUN
bionys-498	1	113	center	center	NOUN
bionys-498	1	114	,	,	PUNCT
bionys-498	1	115	university	university	NOUN
bionys-498	1	116	clinical	clinical	ADJ
bionys-498	1	117	center	center	NOUN
bionys-498	1	118	niš	niš	PROPN
bionys-498	1	119	,	,	PUNCT
bionys-498	1	120	serbia	serbia	PROPN
bionys-498	1	121	perica	perica	PROPN
bionys-498	1	122	vasiljević	vasiljević	PROPN
bionys-498	1	123	department	department	PROPN
bionys-498	1	124	of	of	ADP
bionys-498	1	125	biology	biology	NOUN
bionys-498	1	126	and	and	CCONJ
bionys-498	1	127	ecology	ecology	NOUN
bionys-498	1	128	,	,	PUNCT
bionys-498	1	129	faculty	faculty	NOUN
bionys-498	1	130	of	of	ADP
bionys-498	1	131	sciences	science	NOUN
bionys-498	1	132	and	and	CCONJ
bionys-498	1	133	mathematics	mathematic	NOUN
bionys-498	1	134	,	,	PUNCT
bionys-498	1	135	university	university	NOUN
bionys-498	1	136	of	of	ADP
bionys-498	1	137	niš	niš	PROPN
bionys-498	1	138	,	,	PUNCT
bionys-498	1	139	serbia	serbia	PROPN
bionys-498	1	140	received	receive	VERB
bionys-498	1	141	:	:	PUNCT
bionys-498	1	142	february	february	PROPN
bionys-498	1	143	28	28	NUM
bionys-498	1	144	,	,	PUNCT
bionys-498	1	145	2023	2023	NUM
bionys-498	1	146	revised	revise	VERB
bionys-498	1	147	:	:	PUNCT
bionys-498	1	148	april	april	PROPN
bionys-498	1	149	28	28	NUM
bionys-498	1	150	,	,	PUNCT
bionys-498	1	151	2023	2023	NUM
bionys-498	1	152	accepted	accept	VERB
bionys-498	1	153	:	:	PUNCT
bionys-498	1	154	april	april	PROPN
bionys-498	1	155	28	28	NUM
bionys-498	1	156	,	,	PUNCT
bionys-498	1	157	2023	2023	NUM
bionys-498	1	158	abstract	abstract	NOUN
bionys-498	1	159	:	:	PUNCT
bionys-498	1	160	colorectal	colorectal	ADJ
bionys-498	1	161	carcinoma	carcinoma	NOUN
bionys-498	1	162	(	(	PUNCT
bionys-498	1	163	crc	crc	NOUN
bionys-498	1	164	)	)	PUNCT
bionys-498	1	165	represents	represent	VERB
bionys-498	1	166	a	a	DET
bionys-498	1	167	global	global	ADJ
bionys-498	1	168	health	health	NOUN
bionys-498	1	169	problem	problem	NOUN
bionys-498	1	170	.	.	PUNCT
bionys-498	2	1	the	the	DET
bionys-498	2	2	egfr	egfr	NOUN
bionys-498	2	3	signaling	signal	VERB
bionys-498	2	4	pathway	pathway	NOUN
bionys-498	2	5	is	be	AUX
bionys-498	2	6	very	very	ADV
bionys-498	2	7	important	important	ADJ
bionys-498	2	8	in	in	ADP
bionys-498	2	9	the	the	DET
bionys-498	2	10	initiation	initiation	NOUN
bionys-498	2	11	of	of	ADP
bionys-498	2	12	different	different	ADJ
bionys-498	2	13	human	human	ADJ
bionys-498	2	14	epithelial	epithelial	ADJ
bionys-498	2	15	cancers	cancer	NOUN
bionys-498	2	16	and	and	CCONJ
bionys-498	2	17	plays	play	VERB
bionys-498	2	18	a	a	DET
bionys-498	2	19	key	key	ADJ
bionys-498	2	20	role	role	NOUN
bionys-498	2	21	in	in	ADP
bionys-498	2	22	colorectal	colorectal	ADJ
bionys-498	2	23	carcinogenesis	carcinogenesis	NOUN
bionys-498	2	24	.	.	PUNCT
bionys-498	3	1	considering	consider	VERB
bionys-498	3	2	the	the	DET
bionys-498	3	3	role	role	NOUN
bionys-498	3	4	of	of	ADP
bionys-498	3	5	egfr	egfr	NOUN
bionys-498	3	6	as	as	ADP
bionys-498	3	7	a	a	DET
bionys-498	3	8	mitogenic	mitogenic	ADJ
bionys-498	3	9	inducer	inducer	NOUN
bionys-498	3	10	,	,	PUNCT
bionys-498	3	11	this	this	DET
bionys-498	3	12	study	study	NOUN
bionys-498	3	13	aimed	aim	VERB
bionys-498	3	14	to	to	PART
bionys-498	3	15	determine	determine	VERB
bionys-498	3	16	the	the	DET
bionys-498	3	17	frequency	frequency	NOUN
bionys-498	3	18	and	and	CCONJ
bionys-498	3	19	type	type	NOUN
bionys-498	3	20	of	of	ADP
bionys-498	3	21	mutations	mutation	NOUN
bionys-498	3	22	in	in	ADP
bionys-498	3	23	the	the	DET
bionys-498	3	24	egfr	egfr	ADJ
bionys-498	3	25	gene	gene	NOUN
bionys-498	3	26	and	and	CCONJ
bionys-498	3	27	its	its	PRON
bionys-498	3	28	correlation	correlation	NOUN
bionys-498	3	29	with	with	ADP
bionys-498	3	30	clinicopathological	clinicopathological	ADJ
bionys-498	3	31	characteristics	characteristic	NOUN
bionys-498	3	32	of	of	ADP
bionys-498	3	33	patients	patient	NOUN
bionys-498	3	34	with	with	ADP
bionys-498	3	35	crc	crc	NOUN
bionys-498	3	36	on	on	ADP
bionys-498	3	37	the	the	DET
bionys-498	3	38	territory	territory	NOUN
bionys-498	3	39	of	of	ADP
bionys-498	3	40	southeastern	southeastern	ADJ
bionys-498	3	41	serbia	serbia	PROPN
bionys-498	3	42	.	.	PUNCT
bionys-498	4	1	the	the	DET
bionys-498	4	2	genomic	genomic	ADJ
bionys-498	4	3	dna	dna	NOUN
bionys-498	4	4	of	of	ADP
bionys-498	4	5	patients	patient	NOUN
bionys-498	4	6	was	be	AUX
bionys-498	4	7	isolated	isolate	VERB
bionys-498	4	8	from	from	ADP
bionys-498	4	9	formalin	formalin	NOUN
bionys-498	4	10	-	-	PUNCT
bionys-498	4	11	fixed	fix	VERB
bionys-498	4	12	and	and	CCONJ
bionys-498	4	13	paraffin	paraffin	NOUN
bionys-498	4	14	-	-	PUNCT
bionys-498	4	15	embedded	embed	VERB
bionys-498	4	16	tissues	tissue	NOUN
bionys-498	4	17	.	.	PUNCT
bionys-498	5	1	the	the	DET
bionys-498	5	2	presence	presence	NOUN
bionys-498	5	3	of	of	ADP
bionys-498	5	4	mutations	mutation	NOUN
bionys-498	5	5	in	in	ADP
bionys-498	5	6	exons	exon	NOUN
bionys-498	5	7	18	18	NUM
bionys-498	5	8	,	,	PUNCT
bionys-498	5	9	19	19	NUM
bionys-498	5	10	,	,	PUNCT
bionys-498	5	11	20	20	NUM
bionys-498	5	12	,	,	PUNCT
bionys-498	5	13	and	and	CCONJ
bionys-498	5	14	21	21	NUM
bionys-498	5	15	was	be	AUX
bionys-498	5	16	determined	determine	VERB
bionys-498	5	17	by	by	ADP
bionys-498	5	18	the	the	DET
bionys-498	5	19	real	real	ADJ
bionys-498	5	20	-	-	PUNCT
bionys-498	5	21	time	time	NOUN
bionys-498	5	22	pcr	pcr	ADJ
bionys-498	5	23	method	method	NOUN
bionys-498	5	24	.	.	PUNCT
bionys-498	6	1	the	the	DET
bionys-498	6	2	frequency	frequency	NOUN
bionys-498	6	3	of	of	ADP
bionys-498	6	4	mutations	mutation	NOUN
bionys-498	6	5	in	in	ADP
bionys-498	6	6	the	the	DET
bionys-498	6	7	egfr	egfr	ADJ
bionys-498	6	8	gene	gene	NOUN
bionys-498	6	9	in	in	ADP
bionys-498	6	10	crc	crc	NOUN
bionys-498	6	11	patients	patient	NOUN
bionys-498	6	12	of	of	ADP
bionys-498	6	13	southeastern	southeastern	ADJ
bionys-498	6	14	serbia	serbia	PROPN
bionys-498	6	15	was	be	AUX
bionys-498	6	16	7.9	7.9	NUM
bionys-498	6	17	%	%	NOUN
bionys-498	6	18	.	.	PUNCT
bionys-498	7	1	all	all	DET
bionys-498	7	2	detected	detect	VERB
bionys-498	7	3	mutations	mutation	NOUN
bionys-498	7	4	were	be	AUX
bionys-498	7	5	g719x	g719x	VERB
bionys-498	7	6	.	.	PUNCT
bionys-498	8	1	no	no	DET
bionys-498	8	2	statistically	statistically	ADV
bionys-498	8	3	significant	significant	ADJ
bionys-498	8	4	correlation	correlation	NOUN
bionys-498	8	5	was	be	AUX
bionys-498	8	6	found	find	VERB
bionys-498	8	7	between	between	ADP
bionys-498	8	8	mutational	mutational	ADJ
bionys-498	8	9	status	status	NOUN
bionys-498	8	10	in	in	ADP
bionys-498	8	11	the	the	DET
bionys-498	8	12	egfr	egfr	ADJ
bionys-498	8	13	gene	gene	NOUN
bionys-498	8	14	and	and	CCONJ
bionys-498	8	15	the	the	DET
bionys-498	8	16	clinicopathological	clinicopathological	ADJ
bionys-498	8	17	characteristics	characteristic	NOUN
bionys-498	8	18	of	of	ADP
bionys-498	8	19	patients	patient	NOUN
bionys-498	8	20	.	.	PUNCT
bionys-498	9	1	key	key	ADJ
bionys-498	9	2	words	word	NOUN
bionys-498	9	3	:	:	PUNCT
bionys-498	9	4	colorectal	colorectal	ADJ
bionys-498	9	5	carcinoma	carcinoma	NOUN
bionys-498	9	6	,	,	PUNCT
bionys-498	9	7	egfr	egfr	NOUN
bionys-498	9	8	,	,	PUNCT
bionys-498	9	9	mutations	mutation	NOUN
bionys-498	9	10	apstrakt	apstrakt	NOUN
bionys-498	9	11	:	:	PUNCT
bionys-498	9	12	učestalost	učestalost	PROPN
bionys-498	10	1	i	i	PRON
bionys-498	10	2	tip	tip	VERB
bionys-498	10	3	mutacija	mutacija	NOUN
bionys-498	10	4	u	u	NOUN
bionys-498	10	5	egfr	egfr	ADJ
bionys-498	10	6	genu	genu	NOUN
bionys-498	10	7	kod	kod	PROPN
bionys-498	10	8	pacijenata	pacijenata	PROPN
bionys-498	10	9	sa	sa	PROPN
bionys-498	10	10	kolorektalnim	kolorektalnim	PROPN
bionys-498	11	1	karcinomom	karcinomom	PROPN
bionys-498	11	2	u	u	PROPN
bionys-498	11	3	jugoistočnoj	jugoistočnoj	PROPN
bionys-498	11	4	srbiji	srbiji	PROPN
bionys-498	11	5	kolorektalni	kolorektalni	PROPN
bionys-498	11	6	karcinom	karcinom	PROPN
bionys-498	11	7	(	(	PUNCT
bionys-498	11	8	krk	krk	PROPN
bionys-498	11	9	)	)	PUNCT
bionys-498	11	10	predstavlja	predstavlja	NOUN
bionys-498	11	11	globalni	globalni	NOUN
bionys-498	11	12	zdravstveni	zdravstveni	NOUN
bionys-498	11	13	problem	problem	NOUN
bionys-498	11	14	.	.	PUNCT
bionys-498	12	1	egfr	egfr	PROPN
bionys-498	12	2	signalni	signalni	PROPN
bionys-498	12	3	put	put	VERB
bionys-498	12	4	je	je	PROPN
bionys-498	12	5	veoma	veoma	PROPN
bionys-498	12	6	važan	važan	PROPN
bionys-498	12	7	u	u	PROPN
bionys-498	12	8	inicijaciji	inicijaciji	NOUN
bionys-498	12	9	različitih	različitih	NOUN
bionys-498	12	10	humanih	humanih	PROPN
bionys-498	12	11	epitelnih	epitelnih	PROPN
bionys-498	12	12	karcinoma	karcinoma	PROPN
bionys-498	13	1	i	i	PRON
bionys-498	13	2	i	i	PRON
bionys-498	13	3	m	m	VERB
bionys-498	13	4	a	a	DET
bionys-498	13	5	ključnu	ključnu	PROPN
bionys-498	13	6	ulogu	ulogu	ADJ
bionys-498	13	7	u	u	PROPN
bionys-498	13	8	kolorektalnoj	kolorektalnoj	PROPN
bionys-498	13	9	kancerogenezi	kancerogenezi	PROPN
bionys-498	13	10	.	.	PUNCT
bionys-498	13	11	s	s	VERB
bionys-498	13	12	obzirom	obzirom	ADP
bionys-498	13	13	na	na	INTJ
bionys-498	13	14	ulogu	ulogu	ADJ
bionys-498	13	15	egfr	egfr	NOUN
bionys-498	13	16	-	-	PUNCT
bionys-498	13	17	a	a	DET
bionys-498	13	18	kao	kao	PROPN
bionys-498	13	19	mitogenog	mitogenog	PROPN
bionys-498	13	20	inducera	inducera	PROPN
bionys-498	14	1	,	,	PUNCT
bionys-498	14	2	ovo	ovo	PROPN
bionys-498	14	3	istraživanje	istraživanje	PROPN
bionys-498	14	4	imalo	imalo	PROPN
bionys-498	14	5	je	je	PROPN
bionys-498	14	6	za	za	PROPN
bionys-498	14	7	cilj	cilj	PROPN
bionys-498	14	8	da	da	PROPN
bionys-498	14	9	utvrdi	utvrdi	PROPN
bionys-498	14	10	učestalost	učestalost	INTJ
bionys-498	14	11	i	i	PRON
bionys-498	14	12	tip	tip	VERB
bionys-498	14	13	mutacija	mutacija	NOUN
bionys-498	14	14	u	u	PROPN
bionys-498	14	15	genu	genu	NOUN
bionys-498	14	16	za	za	PROPN
bionys-498	14	17	egfr	egfr	PROPN
bionys-498	14	18	,	,	PUNCT
bionys-498	14	19	kao	kao	PROPN
bionys-498	15	1	i	i	PRON
bionys-498	15	2	hjihovu	hjihovu	VERB
bionys-498	15	3	korelaciju	korelaciju	PROPN
bionys-498	15	4	sa	sa	PROPN
bionys-498	15	5	kliničkopatološkim	kliničkopatološkim	PROPN
bionys-498	15	6	karakteristikama	karakteristikama	PROPN
bionys-498	15	7	pacijenata	pacijenata	PROPN
bionys-498	15	8	sa	sa	VERB
bionys-498	15	9	krk	krk	PROPN
bionys-498	15	10	-	-	PUNCT
bionys-498	15	11	om	om	PROPN
bionys-498	15	12	na	na	NOUN
bionys-498	15	13	teritoriji	teritoriji	PROPN
bionys-498	15	14	jugoistočne	jugoistočne	PROPN
bionys-498	15	15	srbije	srbije	PROPN
bionys-498	15	16	.	.	PUNCT
bionys-498	16	1	genomska	genomska	PROPN
bionys-498	16	2	dnk	dnk	PROPN
bionys-498	16	3	pacijenata	pacijenata	VERB
bionys-498	16	4	izolovana	izolovana	PROPN
bionys-498	16	5	je	je	PROPN
bionys-498	17	1	iz	iz	INTJ
bionys-498	17	2	tkiva	tkiva	PROPN
bionys-498	17	3	fiksiranih	fiksiranih	PROPN
bionys-498	17	4	u	u	PROPN
bionys-498	17	5	formalinu	formalinu	NOUN
bionys-498	17	6	i	i	PRON
bionys-498	17	7	ukalupljenih	ukalupljenih	VERB
bionys-498	17	8	u	u	PROPN
bionys-498	17	9	parafin	parafin	NOUN
bionys-498	17	10	.	.	PUNCT
bionys-498	18	1	prisustvo	prisustvo	PROPN
bionys-498	18	2	mutacija	mutacija	PROPN
bionys-498	18	3	u	u	PROPN
bionys-498	18	4	egzonima	egzonima	PROPN
bionys-498	18	5	18	18	NUM
bionys-498	18	6	,	,	PUNCT
bionys-498	18	7	19	19	NUM
bionys-498	18	8	,	,	PUNCT
bionys-498	18	9	20	20	NUM
bionys-498	18	10	i	i	PRON
bionys-498	18	11	21	21	NUM
bionys-498	18	12	određivano	određivano	NOUN
bionys-498	18	13	je	je	X
bionys-498	18	14	real	real	ADJ
bionys-498	18	15	-	-	PUNCT
bionys-498	18	16	time	time	NOUN
bionys-498	18	17	pcr	pcr	PROPN
bionys-498	18	18	metodom	metodom	NOUN
bionys-498	18	19	.	.	PUNCT
bionys-498	19	1	učestalost	učestalost	PROPN
bionys-498	19	2	mutacija	mutacija	PROPN
bionys-498	19	3	egfr	egfr	PROPN
bionys-498	19	4	gena	gena	PROPN
bionys-498	19	5	kod	kod	PROPN
bionys-498	19	6	pacijenata	pacijenata	PROPN
bionys-498	19	7	sa	sa	VERB
bionys-498	19	8	krk	krk	PROPN
bionys-498	19	9	-	-	PUNCT
bionys-498	19	10	om	om	PROPN
bionys-498	19	11	na	na	NOUN
bionys-498	19	12	teritoriji	teritoriji	NOUN
bionys-498	19	13	jugoistočne	jugoistočne	PROPN
bionys-498	19	14	srbije	srbije	PROPN
bionys-498	19	15	iznosila	iznosila	PROPN
bionys-498	19	16	je	je	PROPN
bionys-498	19	17	7,9	7,9	NUM
bionys-498	19	18	%	%	NOUN
bionys-498	19	19	.	.	PUNCT
bionys-498	20	1	sve	sve	NOUN
bionys-498	20	2	otkrivene	otkrivene	NOUN
bionys-498	20	3	mutacije	mutacije	NOUN
bionys-498	20	4	bile	bile	NOUN
bionys-498	20	5	su	su	PROPN
bionys-498	20	6	tipa	tipa	PROPN
bionys-498	20	7	g719x	g719x	PROPN
bionys-498	20	8	.	.	PUNCT
bionys-498	21	1	nije	nije	PROPN
bionys-498	21	2	pronađena	pronađena	PROPN
bionys-498	21	3	statistički	statistički	PROPN
bionys-498	21	4	značajna	značajna	PROPN
bionys-498	21	5	korelacija	korelacija	X
bionys-498	21	6	između	između	VERB
bionys-498	21	7	mutacionog	mutacionog	NOUN
bionys-498	21	8	statusa	statusa	NOUN
bionys-498	21	9	u	u	NOUN
bionys-498	21	10	egfr	egfr	ADJ
bionys-498	21	11	genu	genu	NOUN
bionys-498	21	12	i	i	PRON
bionys-498	21	13	kliničkopatoloških	kliničkopatoloških	VERB
bionys-498	21	14	karakteristika	karakteristika	PROPN
bionys-498	21	15	pacijenata	pacijenata	PROPN
bionys-498	21	16	.	.	PUNCT
bionys-498	22	1	ključne	ključne	PROPN
bionys-498	22	2	reči	reči	NOUN
bionys-498	22	3	:	:	PUNCT
bionys-498	22	4	kolorektalni	kolorektalni	PROPN
bionys-498	22	5	karcinom	karcinom	PROPN
bionys-498	22	6	,	,	PUNCT
bionys-498	22	7	egfr	egfr	NOUN
bionys-498	22	8	,	,	PUNCT
bionys-498	22	9	mutacije	mutacije	NOUN
bionys-498	22	10	introduction	introduction	NOUN
bionys-498	22	11	colorectal	colorectal	ADJ
bionys-498	22	12	carcinoma	carcinoma	NOUN
bionys-498	22	13	(	(	PUNCT
bionys-498	22	14	crc	crc	NOUN
bionys-498	22	15	)	)	PUNCT
bionys-498	22	16	is	be	AUX
bionys-498	22	17	a	a	DET
bionys-498	22	18	malignant	malignant	ADJ
bionys-498	22	19	epithelial	epithelial	ADJ
bionys-498	22	20	tumor	tumor	NOUN
bionys-498	22	21	that	that	PRON
bionys-498	22	22	represents	represent	VERB
bionys-498	22	23	one	one	NUM
bionys-498	22	24	of	of	ADP
bionys-498	22	25	the	the	DET
bionys-498	22	26	major	major	ADJ
bionys-498	22	27	health	health	NOUN
bionys-498	22	28	problems	problem	NOUN
bionys-498	22	29	in	in	ADP
bionys-498	22	30	the	the	DET
bionys-498	22	31	world	world	NOUN
bionys-498	22	32	.	.	PUNCT
bionys-498	23	1	namely	namely	ADV
bionys-498	23	2	,	,	PUNCT
bionys-498	23	3	it	it	PRON
bionys-498	23	4	is	be	AUX
bionys-498	23	5	the	the	DET
bionys-498	23	6	third	third	ADJ
bionys-498	23	7	most	most	ADV
bionys-498	23	8	common	common	ADJ
bionys-498	23	9	cancer	cancer	NOUN
bionys-498	23	10	in	in	ADP
bionys-498	23	11	men	man	NOUN
bionys-498	23	12	and	and	CCONJ
bionys-498	23	13	the	the	DET
bionys-498	23	14	second	second	ADJ
bionys-498	23	15	most	most	ADV
bionys-498	23	16	common	common	ADJ
bionys-498	23	17	cancer	cancer	NOUN
bionys-498	23	18	in	in	ADP
bionys-498	23	19	women	woman	NOUN
bionys-498	23	20	,	,	PUNCT
bionys-498	23	21	accounting	account	VERB
bionys-498	23	22	for	for	ADP
bionys-498	23	23	about	about	ADV
bionys-498	23	24	11	11	NUM
bionys-498	23	25	%	%	NOUN
bionys-498	23	26	of	of	ADP
bionys-498	23	27	all	all	DET
bionys-498	23	28	diagnosed	diagnose	VERB
bionys-498	23	29	cancers	cancer	NOUN
bionys-498	23	30	(	(	PUNCT
bionys-498	23	31	ferlay	ferlay	NOUN
bionys-498	23	32	et	et	PROPN
bionys-498	23	33	al	al	PROPN
bionys-498	23	34	.	.	PROPN
bionys-498	23	35	,	,	PUNCT
bionys-498	23	36	2020	2020	NUM
bionys-498	23	37	)	)	PUNCT
bionys-498	23	38	.	.	PUNCT
bionys-498	24	1	usually	usually	ADV
bionys-498	24	2	,	,	PUNCT
bionys-498	24	3	it	it	PRON
bionys-498	24	4	is	be	AUX
bionys-498	24	5	diagnosed	diagnose	VERB
bionys-498	24	6	in	in	ADP
bionys-498	24	7	the	the	DET
bionys-498	24	8	older	old	ADJ
bionys-498	24	9	population	population	NOUN
bionys-498	24	10	,	,	PUNCT
bionys-498	24	11	however	however	ADV
bionys-498	24	12	,	,	PUNCT
bionys-498	24	13	recent	recent	ADJ
bionys-498	24	14	research	research	NOUN
bionys-498	24	15	shows	show	VERB
bionys-498	24	16	an	an	DET
bionys-498	24	17	increased	increase	VERB
bionys-498	24	18	incidence	incidence	NOUN
bionys-498	24	19	of	of	ADP
bionys-498	24	20	crc	crc	NOUN
bionys-498	24	21	in	in	ADP
bionys-498	24	22	the	the	DET
bionys-498	24	23	younger	young	ADJ
bionys-498	24	24	population	population	NOUN
bionys-498	24	25	as	as	ADV
bionys-498	24	26	well	well	ADV
bionys-498	24	27	(	(	PUNCT
bionys-498	24	28	campos	campos	PROPN
bionys-498	24	29	,	,	PUNCT
bionys-498	24	30	2017	2017	NUM
bionys-498	24	31	;	;	PUNCT
bionys-498	24	32	connel	connel	PROPN
bionys-498	24	33	et	et	PROPN
bionys-498	24	34	al	al	PROPN
bionys-498	24	35	.	.	PROPN
bionys-498	24	36	,	,	PUNCT
bionys-498	24	37	2017	2017	NUM
bionys-498	24	38	)	)	PUNCT
bionys-498	24	39	.	.	PUNCT
bionys-498	25	1	colorectal	colorectal	ADJ
bionys-498	25	2	carcinogenesis	carcinogenesis	NOUN
bionys-498	25	3	is	be	AUX
bionys-498	25	4	a	a	DET
bionys-498	25	5	gradual	gradual	ADJ
bionys-498	25	6	process	process	NOUN
bionys-498	25	7	where	where	SCONJ
bionys-498	25	8	the	the	DET
bionys-498	25	9	clonal	clonal	ADJ
bionys-498	25	10	accumulation	accumulation	NOUN
bionys-498	25	11	of	of	ADP
bionys-498	25	12	genetic	genetic	ADJ
bionys-498	25	13	changes	change	NOUN
bionys-498	25	14	results	result	VERB
bionys-498	25	15	in	in	ADP
bionys-498	25	16	the	the	DET
bionys-498	25	17	loss	loss	NOUN
bionys-498	25	18	of	of	ADP
bionys-498	25	19	cell	cell	NOUN
bionys-498	25	20	cycle	cycle	NOUN
bionys-498	25	21	control	control	NOUN
bionys-498	25	22	,	,	PUNCT
bionys-498	25	23	absence	absence	NOUN
bionys-498	25	24	of	of	ADP
bionys-498	25	25	the	the	DET
bionys-498	25	26	cells	cell	NOUN
bionys-498	25	27	’	'	PUNCT
bionys-498	25	28	natural	natural	ADJ
bionys-498	25	29	response	response	NOUN
bionys-498	25	30	to	to	ADP
bionys-498	25	31	genomic	genomic	ADJ
bionys-498	25	32	damage	damage	NOUN
bionys-498	25	33	,	,	PUNCT
bionys-498	25	34	further	further	ADJ
bionys-498	25	35	accumulation	accumulation	NOUN
bionys-498	25	36	of	of	ADP
bionys-498	25	37	mutations	mutation	NOUN
bionys-498	25	38	and	and	CCONJ
bionys-498	25	39	,	,	PUNCT
bionys-498	25	40	finally	finally	ADV
bionys-498	25	41	,	,	PUNCT
bionys-498	25	42	in	in	ADP
bionys-498	25	43	general	general	ADJ
bionys-498	25	44	genomic	genomic	NOUN
bionys-498	25	45	instability	instability	NOUN
bionys-498	25	46	,	,	PUNCT
bionys-498	25	47	which	which	PRON
bionys-498	25	48	represents	represent	VERB
bionys-498	25	49	the	the	DET
bionys-498	25	50	basic	basic	ADJ
bionys-498	25	51	characteristic	characteristic	NOUN
bionys-498	25	52	of	of	ADP
bionys-498	25	53	malignant	malignant	ADJ
bionys-498	25	54	cells	cell	NOUN
bionys-498	25	55	(	(	PUNCT
bionys-498	25	56	mármol	mármol	X
bionys-498	25	57	et	et	NOUN
bionys-498	25	58	al	al	PROPN
bionys-498	25	59	.	.	PROPN
bionys-498	25	60	,	,	PUNCT
bionys-498	25	61	2017	2017	NUM
bionys-498	25	62	)	)	PUNCT
bionys-498	25	63	.	.	PUNCT
bionys-498	26	1	the	the	DET
bionys-498	26	2	main	main	ADJ
bionys-498	26	3	role	role	NOUN
bionys-498	26	4	in	in	ADP
bionys-498	26	5	the	the	DET
bionys-498	26	6	evolution	evolution	NOUN
bionys-498	26	7	of	of	ADP
bionys-498	26	8	crc	crc	NOUN
bionys-498	26	9	has	have	VERB
bionys-498	26	10	the	the	DET
bionys-498	26	11	dysregulation	dysregulation	NOUN
bionys-498	26	12	of	of	ADP
bionys-498	26	13	several	several	ADJ
bionys-498	26	14	intracellular	intracellular	NOUN
bionys-498	26	15	signaling	signal	VERB
bionys-498	26	16	pathways	pathway	NOUN
bionys-498	26	17	such	such	ADJ
bionys-498	26	18	as	as	ADP
bionys-498	26	19	mitogen	mitogen	NOUN
bionys-498	26	20	-	-	PUNCT
bionys-498	26	21	activated	activate	VERB
bionys-498	26	22	protein	protein	NOUN
bionys-498	26	23	kinase	kinase	NOUN
bionys-498	26	24	(	(	PUNCT
bionys-498	26	25	mapk	mapk	NOUN
bionys-498	26	26	)	)	PUNCT
bionys-498	26	27	and	and	CCONJ
bionys-498	26	28	phosphatidylinositol	phosphatidylinositol	NOUN
bionys-498	26	29	3	3	NUM
bionys-498	26	30	kinase	kinase	NOUN
bionys-498	26	31	(	(	PUNCT
bionys-498	26	32	pi3k)/protein	pi3k)/protein	PROPN
bionys-498	26	33	kinase	kinase	PROPN
bionys-498	26	34	b	b	PROPN
bionys-498	26	35	(	(	PUNCT
bionys-498	26	36	akt	akt	PROPN
bionys-498	26	37	)	)	PUNCT
bionys-498	26	38	signaling	signal	VERB
bionys-498	26	39	pathway	pathway	NOUN
bionys-498	26	40	activated	activate	VERB
bionys-498	26	41	by	by	ADP
bionys-498	26	42	epidermal	epidermal	ADJ
bionys-498	26	43	growth	growth	NOUN
bionys-498	26	44	factor	factor	NOUN
bionys-498	26	45	receptor	receptor	NOUN
bionys-498	26	46	©	©	PROPN
bionys-498	26	47	2023	2023	NUM
bionys-498	26	48	jugović	jugović	NOUN
bionys-498	26	49	et	et	PROPN
bionys-498	26	50	al	al	PROPN
bionys-498	26	51	.	.	PUNCT
bionys-498	27	1	this	this	PRON
bionys-498	27	2	is	be	AUX
bionys-498	27	3	an	an	DET
bionys-498	27	4	open	open	ADJ
bionys-498	27	5	-	-	PUNCT
bionys-498	27	6	access	access	NOUN
bionys-498	27	7	article	article	NOUN
bionys-498	27	8	distributed	distribute	VERB
bionys-498	27	9	under	under	ADP
bionys-498	27	10	the	the	DET
bionys-498	27	11	terms	term	NOUN
bionys-498	27	12	of	of	ADP
bionys-498	27	13	the	the	DET
bionys-498	27	14	creative	creative	ADJ
bionys-498	27	15	commons	common	NOUN
bionys-498	27	16	attribution	attribution	NOUN
bionys-498	27	17	license	license	NOUN
bionys-498	27	18	,	,	PUNCT
bionys-498	27	19	which	which	PRON
bionys-498	27	20	permits	permit	VERB
bionys-498	27	21	unrestricted	unrestricted	ADJ
bionys-498	27	22	use	use	NOUN
bionys-498	27	23	,	,	PUNCT
bionys-498	27	24	distribution	distribution	NOUN
bionys-498	27	25	,	,	PUNCT
bionys-498	27	26	and	and	CCONJ
bionys-498	27	27	build	build	VERB
bionys-498	27	28	upon	upon	SCONJ
bionys-498	27	29	your	your	PRON
bionys-498	27	30	work	work	NOUN
bionys-498	27	31	non	non	ADJ
bionys-498	27	32	-	-	ADJ
bionys-498	27	33	commercially	commercially	ADV
bionys-498	27	34	under	under	ADP
bionys-498	27	35	the	the	DET
bionys-498	27	36	same	same	ADJ
bionys-498	27	37	license	license	NOUN
bionys-498	27	38	as	as	ADP
bionys-498	27	39	the	the	DET
bionys-498	27	40	original	original	NOUN
bionys-498	27	41	.	.	PUNCT
bionys-498	28	1	39	39	NUM
bionys-498	28	2	(	(	PUNCT
bionys-498	28	3	egfr	egfr	X
bionys-498	28	4	)	)	PUNCT
bionys-498	28	5	bounded	bound	VERB
bionys-498	28	6	with	with	ADP
bionys-498	28	7	the	the	DET
bionys-498	28	8	ligand	ligand	NOUN
bionys-498	28	9	.	.	PUNCT
bionys-498	29	1	dysregulation	dysregulation	NOUN
bionys-498	29	2	of	of	ADP
bionys-498	29	3	these	these	DET
bionys-498	29	4	pathways	pathway	NOUN
bionys-498	29	5	leads	lead	VERB
bionys-498	29	6	to	to	ADP
bionys-498	29	7	the	the	DET
bionys-498	29	8	activation	activation	NOUN
bionys-498	29	9	of	of	ADP
bionys-498	29	10	various	various	ADJ
bionys-498	29	11	transcription	transcription	NOUN
bionys-498	29	12	factors	factor	NOUN
bionys-498	29	13	whose	whose	DET
bionys-498	29	14	disruption	disruption	NOUN
bionys-498	29	15	can	can	AUX
bionys-498	29	16	lead	lead	VERB
bionys-498	29	17	to	to	ADP
bionys-498	29	18	malignant	malignant	ADJ
bionys-498	29	19	cell	cell	NOUN
bionys-498	29	20	transformation	transformation	NOUN
bionys-498	29	21	and	and	CCONJ
bionys-498	29	22	tumor	tumor	NOUN
bionys-498	29	23	progression	progression	NOUN
bionys-498	29	24	through	through	ADP
bionys-498	29	25	increased	increase	VERB
bionys-498	29	26	cell	cell	NOUN
bionys-498	29	27	proliferation	proliferation	NOUN
bionys-498	29	28	,	,	PUNCT
bionys-498	29	29	anti	anti	ADJ
bionys-498	29	30	-	-	ADJ
bionys-498	29	31	apoptosis	apoptosis	ADJ
bionys-498	29	32	,	,	PUNCT
bionys-498	29	33	angiogenesis	angiogenesis	NOUN
bionys-498	29	34	,	,	PUNCT
bionys-498	29	35	and	and	CCONJ
bionys-498	29	36	invasion	invasion	NOUN
bionys-498	29	37	(	(	PUNCT
bionys-498	29	38	wee	wee	ADJ
bionys-498	29	39	et	et	PROPN
bionys-498	29	40	al	al	PROPN
bionys-498	29	41	.	.	PROPN
bionys-498	29	42	,	,	PUNCT
bionys-498	29	43	2017	2017	NUM
bionys-498	29	44	;	;	PUNCT
bionys-498	29	45	koveitypour	koveitypour	PROPN
bionys-498	29	46	et	et	PROPN
bionys-498	29	47	al	al	PROPN
bionys-498	29	48	.	.	PROPN
bionys-498	29	49	,	,	PUNCT
bionys-498	29	50	2019	2019	NUM
bionys-498	29	51	)	)	PUNCT
bionys-498	29	52	.	.	PUNCT
bionys-498	30	1	the	the	DET
bionys-498	30	2	egfr	egfr	ADJ
bionys-498	30	3	gene	gene	NOUN
bionys-498	30	4	is	be	AUX
bionys-498	30	5	located	locate	VERB
bionys-498	30	6	on	on	ADP
bionys-498	30	7	chromosome	chromosome	NOUN
bionys-498	30	8	7p12	7p12	NUM
bionys-498	30	9	–	–	PUNCT
bionys-498	30	10	13	13	NUM
bionys-498	30	11	.	.	PUNCT
bionys-498	31	1	it	it	PRON
bionys-498	31	2	encodes	encode	VERB
bionys-498	31	3	a	a	DET
bionys-498	31	4	170	170	NUM
bionys-498	31	5	-	-	PUNCT
bionys-498	31	6	kda	kda	NOUN
bionys-498	31	7	transmembrane	transmembrane	NOUN
bionys-498	31	8	receptor	receptor	NOUN
bionys-498	31	9	with	with	ADP
bionys-498	31	10	an	an	DET
bionys-498	31	11	intracellular	intracellular	ADJ
bionys-498	31	12	tyrosine	tyrosine	NOUN
bionys-498	31	13	kinase	kinase	NOUN
bionys-498	31	14	domain	domain	PROPN
bionys-498	31	15	.	.	PUNCT
bionys-498	32	1	it	it	PRON
bionys-498	32	2	is	be	AUX
bionys-498	32	3	a	a	DET
bionys-498	32	4	member	member	NOUN
bionys-498	32	5	of	of	ADP
bionys-498	32	6	the	the	DET
bionys-498	32	7	erbb	erbb	PROPN
bionys-498	32	8	family	family	NOUN
bionys-498	32	9	of	of	ADP
bionys-498	32	10	receptors	receptor	NOUN
bionys-498	32	11	that	that	PRON
bionys-498	32	12	has	have	VERB
bionys-498	32	13	four	four	NUM
bionys-498	32	14	closely	closely	ADV
bionys-498	32	15	related	relate	VERB
bionys-498	32	16	members	member	NOUN
bionys-498	32	17	:	:	PUNCT
bionys-498	32	18	erbb-1bb-1	erbb-1bb-1	NUM
bionys-498	32	19	(	(	PUNCT
bionys-498	32	20	her1/	her1/	PROPN
bionys-498	32	21	egfr	egfr	NOUN
bionys-498	32	22	)	)	PUNCT
bionys-498	32	23	,	,	PUNCT
bionys-498	32	24	erbb-2	erbb-2	PROPN
bionys-498	32	25	(	(	PUNCT
bionys-498	32	26	her2	her2	PROPN
bionys-498	32	27	)	)	PUNCT
bionys-498	32	28	,	,	PUNCT
bionys-498	32	29	erbb-3	erbb-3	PROPN
bionys-498	32	30	(	(	PUNCT
bionys-498	32	31	her3	her3	PROPN
bionys-498	32	32	)	)	PUNCT
bionys-498	32	33	,	,	PUNCT
bionys-498	32	34	and	and	CCONJ
bionys-498	32	35	erbb-4	erbb-4	NUM
bionys-498	32	36	(	(	PUNCT
bionys-498	32	37	her4	her4	PROPN
bionys-498	32	38	)	)	PUNCT
bionys-498	32	39	.	.	PUNCT
bionys-498	33	1	all	all	DET
bionys-498	33	2	these	these	DET
bionys-498	33	3	receptors	receptor	NOUN
bionys-498	33	4	contain	contain	VERB
bionys-498	33	5	an	an	DET
bionys-498	33	6	extracellular	extracellular	ADJ
bionys-498	33	7	ligand	ligand	NOUN
bionys-498	33	8	-	-	PUNCT
bionys-498	33	9	binding	bind	VERB
bionys-498	33	10	domain	domain	NOUN
bionys-498	33	11	,	,	PUNCT
bionys-498	33	12	a	a	DET
bionys-498	33	13	membranespanning	membranespanne	VERB
bionys-498	33	14	region	region	NOUN
bionys-498	33	15	,	,	PUNCT
bionys-498	33	16	and	and	CCONJ
bionys-498	33	17	a	a	DET
bionys-498	33	18	cytoplasmic	cytoplasmic	ADJ
bionys-498	33	19	region	region	NOUN
bionys-498	33	20	which	which	PRON
bionys-498	33	21	contains	contain	VERB
bionys-498	33	22	a	a	DET
bionys-498	33	23	tyrosine	tyrosine	NOUN
bionys-498	33	24	kinase	kinase	NOUN
bionys-498	33	25	(	(	PUNCT
bionys-498	33	26	hirsh	hirsh	PROPN
bionys-498	33	27	,	,	PUNCT
bionys-498	33	28	2018	2018	NUM
bionys-498	33	29	)	)	PUNCT
bionys-498	33	30	.	.	PUNCT
bionys-498	34	1	after	after	ADP
bionys-498	34	2	epidermal	epidermal	ADJ
bionys-498	34	3	growth	growth	NOUN
bionys-498	34	4	factor	factor	NOUN
bionys-498	34	5	(	(	PUNCT
bionys-498	34	6	egf	egf	PROPN
bionys-498	34	7	)	)	PUNCT
bionys-498	34	8	ligand	ligand	NOUN
bionys-498	34	9	binding	bind	VERB
bionys-498	34	10	,	,	PUNCT
bionys-498	34	11	egfr	egfr	NOUN
bionys-498	34	12	forms	form	VERB
bionys-498	34	13	a	a	DET
bionys-498	34	14	functionally	functionally	ADV
bionys-498	34	15	active	active	ADJ
bionys-498	34	16	dimer	dimer	NOUN
bionys-498	34	17	(	(	PUNCT
bionys-498	34	18	homodimer	homodimer	NOUN
bionys-498	34	19	or	or	CCONJ
bionys-498	34	20	heterodimer	heterodimer	NOUN
bionys-498	34	21	)	)	PUNCT
bionys-498	34	22	that	that	PRON
bionys-498	34	23	causes	cause	VERB
bionys-498	34	24	phosphorylation	phosphorylation	NOUN
bionys-498	34	25	of	of	ADP
bionys-498	34	26	tyrosine	tyrosine	NOUN
bionys-498	34	27	kinases	kinase	NOUN
bionys-498	34	28	in	in	ADP
bionys-498	34	29	the	the	DET
bionys-498	34	30	intracellular	intracellular	ADJ
bionys-498	34	31	domain	domain	NOUN
bionys-498	34	32	of	of	ADP
bionys-498	34	33	egfr	egfr	NOUN
bionys-498	34	34	.	.	PUNCT
bionys-498	35	1	this	this	DET
bionys-498	35	2	phosphorylation	phosphorylation	NOUN
bionys-498	35	3	initiates	initiate	VERB
bionys-498	35	4	different	different	ADJ
bionys-498	35	5	complex	complex	ADJ
bionys-498	35	6	intracellular	intracellular	ADJ
bionys-498	35	7	signals	signal	NOUN
bionys-498	35	8	in	in	ADP
bionys-498	35	9	the	the	DET
bionys-498	35	10	cytoplasm	cytoplasm	NOUN
bionys-498	35	11	followed	follow	VERB
bionys-498	35	12	by	by	ADP
bionys-498	35	13	the	the	DET
bionys-498	35	14	activation	activation	NOUN
bionys-498	35	15	of	of	ADP
bionys-498	35	16	a	a	DET
bionys-498	35	17	variety	variety	NOUN
bionys-498	35	18	of	of	ADP
bionys-498	35	19	transcription	transcription	NOUN
bionys-498	35	20	factors	factor	NOUN
bionys-498	35	21	responsible	responsible	ADJ
bionys-498	35	22	for	for	ADP
bionys-498	35	23	controlling	control	VERB
bionys-498	35	24	multiple	multiple	ADJ
bionys-498	35	25	cellular	cellular	ADJ
bionys-498	35	26	functions	function	NOUN
bionys-498	35	27	including	include	VERB
bionys-498	35	28	proliferation	proliferation	NOUN
bionys-498	35	29	,	,	PUNCT
bionys-498	35	30	differentiation	differentiation	NOUN
bionys-498	35	31	,	,	PUNCT
bionys-498	35	32	apoptosis	apoptosis	NOUN
bionys-498	35	33	,	,	PUNCT
bionys-498	35	34	and	and	CCONJ
bionys-498	35	35	cell	cell	NOUN
bionys-498	35	36	migration	migration	NOUN
bionys-498	35	37	(	(	PUNCT
bionys-498	35	38	koveitypour	koveitypour	NOUN
bionys-498	35	39	et	et	PROPN
bionys-498	35	40	al	al	PROPN
bionys-498	35	41	.	.	PROPN
bionys-498	35	42	,	,	PUNCT
bionys-498	35	43	2019	2019	NUM
bionys-498	35	44	)	)	PUNCT
bionys-498	35	45	.	.	PUNCT
bionys-498	36	1	the	the	DET
bionys-498	36	2	presence	presence	NOUN
bionys-498	36	3	of	of	ADP
bionys-498	36	4	mutations	mutation	NOUN
bionys-498	36	5	in	in	ADP
bionys-498	36	6	some	some	DET
bionys-498	36	7	genes	gene	NOUN
bionys-498	36	8	involved	involve	VERB
bionys-498	36	9	in	in	ADP
bionys-498	36	10	these	these	DET
bionys-498	36	11	signaling	signal	VERB
bionys-498	36	12	pathways	pathway	NOUN
bionys-498	36	13	often	often	ADV
bionys-498	36	14	represents	represent	VERB
bionys-498	36	15	a	a	DET
bionys-498	36	16	negative	negative	ADJ
bionys-498	36	17	predictive	predictive	ADJ
bionys-498	36	18	biomarker	biomarker	NOUN
bionys-498	36	19	of	of	ADP
bionys-498	36	20	response	response	NOUN
bionys-498	36	21	to	to	ADP
bionys-498	36	22	current	current	ADJ
bionys-498	36	23	therapy	therapy	NOUN
bionys-498	36	24	(	(	PUNCT
bionys-498	36	25	mármol	mármol	NOUN
bionys-498	36	26	et	et	NOUN
bionys-498	36	27	al	al	PROPN
bionys-498	36	28	.	.	PROPN
bionys-498	36	29	,	,	PUNCT
bionys-498	36	30	2017	2017	NUM
bionys-498	36	31	)	)	PUNCT
bionys-498	36	32	.	.	PUNCT
bionys-498	37	1	the	the	DET
bionys-498	37	2	principal	principal	ADJ
bionys-498	37	3	mechanism	mechanism	NOUN
bionys-498	37	4	of	of	ADP
bionys-498	37	5	egfr	egfr	ADJ
bionys-498	37	6	dysregulation	dysregulation	NOUN
bionys-498	37	7	in	in	ADP
bionys-498	37	8	crc	crc	NOUN
bionys-498	37	9	is	be	AUX
bionys-498	37	10	egfr	egfr	ADJ
bionys-498	37	11	overexpression	overexpression	NOUN
bionys-498	37	12	.	.	PUNCT
bionys-498	38	1	protein	protein	NOUN
bionys-498	38	2	upregulation	upregulation	NOUN
bionys-498	38	3	is	be	AUX
bionys-498	38	4	found	find	VERB
bionys-498	38	5	in	in	ADP
bionys-498	38	6	60	60	NUM
bionys-498	38	7	-	-	SYM
bionys-498	38	8	80	80	NUM
bionys-498	38	9	%	%	NOUN
bionys-498	38	10	of	of	ADP
bionys-498	38	11	crc	crc	NOUN
bionys-498	38	12	,	,	PUNCT
bionys-498	38	13	making	make	VERB
bionys-498	38	14	it	it	PRON
bionys-498	38	15	an	an	DET
bionys-498	38	16	adequate	adequate	ADJ
bionys-498	38	17	target	target	NOUN
bionys-498	38	18	for	for	ADP
bionys-498	38	19	anti	anti	ADJ
bionys-498	38	20	-	-	ADJ
bionys-498	38	21	egfr	egfr	ADJ
bionys-498	38	22	therapy	therapy	NOUN
bionys-498	38	23	(	(	PUNCT
bionys-498	38	24	porru	porru	NOUN
bionys-498	38	25	et	et	PROPN
bionys-498	38	26	al	al	PROPN
bionys-498	38	27	.	.	PROPN
bionys-498	38	28	,	,	PUNCT
bionys-498	38	29	2018	2018	NUM
bionys-498	38	30	)	)	PUNCT
bionys-498	38	31	.	.	PUNCT
bionys-498	39	1	nowadays	nowadays	ADV
bionys-498	39	2	,	,	PUNCT
bionys-498	39	3	in	in	ADP
bionys-498	39	4	addition	addition	NOUN
bionys-498	39	5	to	to	ADP
bionys-498	39	6	the	the	DET
bionys-498	39	7	standard	standard	ADJ
bionys-498	39	8	chemotherapy	chemotherapy	NOUN
bionys-498	39	9	,	,	PUNCT
bionys-498	39	10	there	there	PRON
bionys-498	39	11	are	be	VERB
bionys-498	39	12	two	two	NUM
bionys-498	39	13	other	other	ADJ
bionys-498	39	14	therapeutic	therapeutic	ADJ
bionys-498	39	15	approaches	approach	NOUN
bionys-498	39	16	in	in	ADP
bionys-498	39	17	the	the	DET
bionys-498	39	18	treatment	treatment	NOUN
bionys-498	39	19	of	of	ADP
bionys-498	39	20	cancer	cancer	NOUN
bionys-498	39	21	,	,	PUNCT
bionys-498	39	22	i.e.	i.e.	X
bionys-498	39	23	,	,	PUNCT
bionys-498	39	24	administration	administration	NOUN
bionys-498	39	25	of	of	ADP
bionys-498	39	26	tyrosine	tyrosine	PROPN
bionys-498	39	27	kinase	kinase	PROPN
bionys-498	39	28	inhibitors	inhibitor	NOUN
bionys-498	39	29	(	(	PUNCT
bionys-498	39	30	tki	tki	NOUN
bionys-498	39	31	)	)	PUNCT
bionys-498	39	32	and	and	CCONJ
bionys-498	39	33	administration	administration	NOUN
bionys-498	39	34	of	of	ADP
bionys-498	39	35	monoclonal	monoclonal	NOUN
bionys-498	39	36	antibodies	antibody	NOUN
bionys-498	39	37	(	(	PUNCT
bionys-498	39	38	mabs	mab	NOUN
bionys-498	39	39	)	)	PUNCT
bionys-498	39	40	.	.	PUNCT
bionys-498	40	1	although	although	SCONJ
bionys-498	40	2	the	the	DET
bionys-498	40	3	mechanism	mechanism	NOUN
bionys-498	40	4	of	of	ADP
bionys-498	40	5	these	these	DET
bionys-498	40	6	two	two	NUM
bionys-498	40	7	therapies	therapy	NOUN
bionys-498	40	8	is	be	AUX
bionys-498	40	9	similar	similar	ADJ
bionys-498	40	10	,	,	PUNCT
bionys-498	40	11	i.e.	i.e.	X
bionys-498	40	12	,	,	PUNCT
bionys-498	40	13	blocking	blocking	NOUN
bionys-498	40	14	of	of	ADP
bionys-498	40	15	the	the	DET
bionys-498	40	16	egfr	egfr	ADJ
bionys-498	40	17	autophosphorylation	autophosphorylation	NOUN
bionys-498	40	18	,	,	PUNCT
bionys-498	40	19	the	the	DET
bionys-498	40	20	outcome	outcome	NOUN
bionys-498	40	21	of	of	ADP
bionys-498	40	22	the	the	DET
bionys-498	40	23	therapy	therapy	NOUN
bionys-498	40	24	may	may	AUX
bionys-498	40	25	differ	differ	VERB
bionys-498	40	26	depending	depend	VERB
bionys-498	40	27	on	on	ADP
bionys-498	40	28	the	the	DET
bionys-498	40	29	mutational	mutational	ADJ
bionys-498	40	30	status	status	NOUN
bionys-498	40	31	of	of	ADP
bionys-498	40	32	egfr	egfr	NOUN
bionys-498	40	33	.	.	PUNCT
bionys-498	41	1	to	to	ADP
bionys-498	41	2	wit	wit	NOUN
bionys-498	41	3	,	,	PUNCT
bionys-498	41	4	studies	study	NOUN
bionys-498	41	5	showed	show	VERB
bionys-498	41	6	that	that	SCONJ
bionys-498	41	7	the	the	DET
bionys-498	41	8	administration	administration	NOUN
bionys-498	41	9	of	of	ADP
bionys-498	41	10	tki	tki	PROPN
bionys-498	41	11	failed	fail	VERB
bionys-498	41	12	to	to	PART
bionys-498	41	13	improve	improve	VERB
bionys-498	41	14	the	the	DET
bionys-498	41	15	outcome	outcome	NOUN
bionys-498	41	16	of	of	ADP
bionys-498	41	17	the	the	DET
bionys-498	41	18	treatment	treatment	NOUN
bionys-498	41	19	in	in	ADP
bionys-498	41	20	crc	crc	NOUN
bionys-498	41	21	patients	patient	NOUN
bionys-498	41	22	with	with	ADP
bionys-498	41	23	egfr	egfr	ADJ
bionys-498	41	24	mutations	mutation	NOUN
bionys-498	41	25	in	in	ADP
bionys-498	41	26	the	the	DET
bionys-498	41	27	tk	tk	PROPN
bionys-498	41	28	domain	domain	NOUN
bionys-498	41	29	located	locate	VERB
bionys-498	41	30	in	in	ADP
bionys-498	41	31	exons	exon	NOUN
bionys-498	41	32	8,19	8,19	NUM
bionys-498	41	33	,	,	PUNCT
bionys-498	41	34	20	20	NUM
bionys-498	41	35	and	and	CCONJ
bionys-498	41	36	21	21	NUM
bionys-498	41	37	(	(	PUNCT
bionys-498	41	38	saletti	saletti	PROPN
bionys-498	41	39	et	et	PROPN
bionys-498	41	40	al	al	PROPN
bionys-498	41	41	.	.	PROPN
bionys-498	41	42	,	,	PUNCT
bionys-498	41	43	2015	2015	NUM
bionys-498	41	44	)	)	PUNCT
bionys-498	41	45	.	.	PUNCT
bionys-498	42	1	on	on	ADP
bionys-498	42	2	the	the	DET
bionys-498	42	3	other	other	ADJ
bionys-498	42	4	hand	hand	NOUN
bionys-498	42	5	,	,	PUNCT
bionys-498	42	6	the	the	DET
bionys-498	42	7	study	study	NOUN
bionys-498	42	8	of	of	ADP
bionys-498	42	9	cho	cho	PROPN
bionys-498	42	10	and	and	CCONJ
bionys-498	42	11	associates	associate	NOUN
bionys-498	42	12	showed	show	VERB
bionys-498	42	13	that	that	SCONJ
bionys-498	42	14	cell	cell	NOUN
bionys-498	42	15	lines	line	NOUN
bionys-498	42	16	that	that	PRON
bionys-498	42	17	express	express	VERB
bionys-498	42	18	g719s	g719s	PROPN
bionys-498	42	19	and	and	CCONJ
bionys-498	42	20	g724s	g724s	PROPN
bionys-498	42	21	mutations	mutation	NOUN
bionys-498	42	22	in	in	ADP
bionys-498	42	23	exon	exon	NOUN
bionys-498	42	24	18	18	NUM
bionys-498	42	25	are	be	AUX
bionys-498	42	26	sensitive	sensitive	ADJ
bionys-498	42	27	to	to	ADP
bionys-498	42	28	the	the	DET
bionys-498	42	29	cetuximab	cetuximab	NOUN
bionys-498	42	30	monoclonal	monoclonal	NOUN
bionys-498	42	31	antibody	antibody	NOUN
bionys-498	42	32	(	(	PUNCT
bionys-498	42	33	cho	cho	NOUN
bionys-498	42	34	et	et	PROPN
bionys-498	42	35	al	al	PROPN
bionys-498	42	36	.	.	PROPN
bionys-498	42	37	,	,	PUNCT
bionys-498	42	38	2014	2014	NUM
bionys-498	42	39	)	)	PUNCT
bionys-498	42	40	.	.	PUNCT
bionys-498	43	1	thus	thus	ADV
bionys-498	43	2	,	,	PUNCT
bionys-498	43	3	patients	patient	NOUN
bionys-498	43	4	that	that	PRON
bionys-498	43	5	are	be	AUX
bionys-498	43	6	carriers	carrier	NOUN
bionys-498	43	7	of	of	ADP
bionys-498	43	8	these	these	DET
bionys-498	43	9	mutations	mutation	NOUN
bionys-498	43	10	might	might	AUX
bionys-498	43	11	benefit	benefit	VERB
bionys-498	43	12	from	from	ADP
bionys-498	43	13	the	the	DET
bionys-498	43	14	use	use	NOUN
bionys-498	43	15	of	of	ADP
bionys-498	43	16	cetuximab	cetuximab	NOUN
bionys-498	43	17	,	,	PUNCT
bionys-498	43	18	even	even	ADV
bionys-498	43	19	though	though	SCONJ
bionys-498	43	20	it	it	PRON
bionys-498	43	21	is	be	AUX
bionys-498	43	22	still	still	ADV
bionys-498	43	23	mainly	mainly	ADV
bionys-498	43	24	used	use	VERB
bionys-498	43	25	only	only	ADV
bionys-498	43	26	in	in	ADP
bionys-498	43	27	the	the	DET
bionys-498	43	28	treatment	treatment	NOUN
bionys-498	43	29	of	of	ADP
bionys-498	43	30	metastatic	metastatic	ADJ
bionys-498	43	31	crc	crc	NOUN
bionys-498	43	32	patients	patient	NOUN
bionys-498	43	33	with	with	ADP
bionys-498	43	34	wild	wild	ADJ
bionys-498	43	35	-	-	PUNCT
bionys-498	43	36	type	type	NOUN
bionys-498	43	37	(	(	PUNCT
bionys-498	43	38	wt	wt	NOUN
bionys-498	43	39	)	)	PUNCT
bionys-498	43	40	kras	kras	PROPN
bionys-498	43	41	.	.	PUNCT
bionys-498	44	1	moreover	moreover	ADV
bionys-498	44	2	,	,	PUNCT
bionys-498	44	3	although	although	SCONJ
bionys-498	44	4	somatic	somatic	ADJ
bionys-498	44	5	mutations	mutation	NOUN
bionys-498	44	6	are	be	AUX
bionys-498	44	7	rare	rare	ADJ
bionys-498	44	8	in	in	ADP
bionys-498	44	9	crc	crc	PROPN
bionys-498	44	10	,	,	PUNCT
bionys-498	44	11	some	some	PRON
bionys-498	44	12	of	of	ADP
bionys-498	44	13	them	they	PRON
bionys-498	44	14	can	can	AUX
bionys-498	44	15	cause	cause	VERB
bionys-498	44	16	acquired	acquire	VERB
bionys-498	44	17	resistance	resistance	NOUN
bionys-498	44	18	to	to	ADP
bionys-498	44	19	anti	anti	ADJ
bionys-498	44	20	-	-	ADJ
bionys-498	44	21	egfr	egfr	ADJ
bionys-498	44	22	therapy	therapy	NOUN
bionys-498	44	23	(	(	PUNCT
bionys-498	44	24	montagut	montagut	PROPN
bionys-498	44	25	et	et	PROPN
bionys-498	44	26	al	al	PROPN
bionys-498	44	27	.	.	PROPN
bionys-498	44	28	,	,	PUNCT
bionys-498	44	29	2012	2012	NUM
bionys-498	44	30	;	;	PUNCT
bionys-498	44	31	cho	cho	PROPN
bionys-498	44	32	et	et	PROPN
bionys-498	44	33	al	al	PROPN
bionys-498	44	34	.	.	PROPN
bionys-498	44	35	,	,	PUNCT
bionys-498	44	36	2014	2014	NUM
bionys-498	44	37	)	)	PUNCT
bionys-498	44	38	.	.	PUNCT
bionys-498	45	1	the	the	DET
bionys-498	45	2	most	most	ADV
bionys-498	45	3	common	common	ADJ
bionys-498	45	4	somatic	somatic	ADJ
bionys-498	45	5	mutations	mutation	NOUN
bionys-498	45	6	that	that	PRON
bionys-498	45	7	lead	lead	VERB
bionys-498	45	8	to	to	ADP
bionys-498	45	9	the	the	DET
bionys-498	45	10	oncogene	oncogene	NOUN
bionys-498	45	11	activation	activation	NOUN
bionys-498	45	12	of	of	ADP
bionys-498	45	13	egfr	egfr	NOUN
bionys-498	45	14	are	be	AUX
bionys-498	45	15	missense	missense	NOUN
bionys-498	45	16	mutations	mutation	NOUN
bionys-498	45	17	,	,	PUNCT
bionys-498	45	18	insertions	insertion	NOUN
bionys-498	45	19	,	,	PUNCT
bionys-498	45	20	or	or	CCONJ
bionys-498	45	21	deletions	deletion	NOUN
bionys-498	45	22	,	,	PUNCT
bionys-498	45	23	mainly	mainly	ADV
bionys-498	45	24	in	in	ADP
bionys-498	45	25	the	the	DET
bionys-498	45	26	tyrosine	tyrosine	NOUN
bionys-498	45	27	kinase	kinase	PROPN
bionys-498	45	28	(	(	PUNCT
bionys-498	45	29	tk	tk	PROPN
bionys-498	45	30	)	)	PUNCT
bionys-498	45	31	domain	domain	NOUN
bionys-498	45	32	(	(	PUNCT
bionys-498	45	33	liu	liu	PROPN
bionys-498	45	34	et	et	PROPN
bionys-498	45	35	al	al	PROPN
bionys-498	45	36	.	.	PROPN
bionys-498	45	37	,	,	PUNCT
bionys-498	45	38	2020	2020	NUM
bionys-498	45	39	)	)	PUNCT
bionys-498	45	40	.	.	PUNCT
bionys-498	46	1	according	accord	VERB
bionys-498	46	2	to	to	ADP
bionys-498	46	3	the	the	DET
bionys-498	46	4	study	study	NOUN
bionys-498	46	5	of	of	ADP
bionys-498	46	6	metzger	metzger	NOUN
bionys-498	46	7	and	and	CCONJ
bionys-498	46	8	associates	associate	NOUN
bionys-498	46	9	,	,	PUNCT
bionys-498	46	10	the	the	DET
bionys-498	46	11	frequency	frequency	NOUN
bionys-498	46	12	of	of	ADP
bionys-498	46	13	mutations	mutation	NOUN
bionys-498	46	14	in	in	ADP
bionys-498	46	15	the	the	DET
bionys-498	46	16	egfr	egfr	ADJ
bionys-498	46	17	tk	tk	PROPN
bionys-498	46	18	domain	domain	NOUN
bionys-498	46	19	of	of	ADP
bionys-498	46	20	crc	crc	NOUN
bionys-498	46	21	patients	patient	NOUN
bionys-498	46	22	in	in	ADP
bionys-498	46	23	europe	europe	PROPN
bionys-498	46	24	is	be	AUX
bionys-498	46	25	3.8	3.8	NUM
bionys-498	46	26	%	%	NOUN
bionys-498	46	27	in	in	ADP
bionys-498	46	28	exon	exon	PROPN
bionys-498	46	29	21	21	NUM
bionys-498	46	30	(	(	PUNCT
bionys-498	46	31	codons	codon	NOUN
bionys-498	46	32	847	847	NUM
bionys-498	46	33	,	,	PUNCT
bionys-498	46	34	836	836	NUM
bionys-498	46	35	)	)	PUNCT
bionys-498	46	36	,	,	PUNCT
bionys-498	46	37	2.6	2.6	NUM
bionys-498	46	38	%	%	NOUN
bionys-498	46	39	in	in	ADP
bionys-498	46	40	exon	exon	PROPN
bionys-498	46	41	18	18	NUM
bionys-498	46	42	(	(	PUNCT
bionys-498	46	43	codons	codon	NOUN
bionys-498	46	44	707	707	NUM
bionys-498	46	45	,	,	PUNCT
bionys-498	46	46	710	710	NUM
bionys-498	46	47	,	,	PUNCT
bionys-498	46	48	711	711	NUM
bionys-498	46	49	,	,	PUNCT
bionys-498	46	50	712	712	NUM
bionys-498	46	51	,	,	PUNCT
bionys-498	46	52	725	725	NUM
bionys-498	46	53	)	)	PUNCT
bionys-498	46	54	,	,	PUNCT
bionys-498	46	55	0.8	0.8	NUM
bionys-498	46	56	%	%	NOUN
bionys-498	46	57	in	in	ADP
bionys-498	46	58	exon	exon	NOUN
bionys-498	46	59	20	20	NUM
bionys-498	46	60	(	(	PUNCT
bionys-498	46	61	codons	codon	NOUN
bionys-498	46	62	795	795	NUM
bionys-498	46	63	,	,	PUNCT
bionys-498	46	64	796	796	NUM
bionys-498	46	65	,	,	PUNCT
bionys-498	46	66	787	787	NUM
bionys-498	46	67	)	)	PUNCT
bionys-498	46	68	,	,	PUNCT
bionys-498	46	69	and	and	CCONJ
bionys-498	46	70	only	only	ADV
bionys-498	46	71	0.5	0.5	NUM
bionys-498	46	72	%	%	NOUN
bionys-498	46	73	in	in	ADP
bionys-498	46	74	exon	exon	PROPN
bionys-498	46	75	19	19	NUM
bionys-498	46	76	(	(	PUNCT
bionys-498	46	77	codon	codon	NOUN
bionys-498	46	78	742	742	NUM
bionys-498	46	79	)	)	PUNCT
bionys-498	46	80	(	(	PUNCT
bionys-498	46	81	metzger	metzger	NOUN
bionys-498	46	82	et	et	PROPN
bionys-498	46	83	al	al	PROPN
bionys-498	46	84	.	.	PROPN
bionys-498	46	85	,	,	PUNCT
bionys-498	46	86	2011	2011	NUM
bionys-498	46	87	)	)	PUNCT
bionys-498	46	88	.	.	PUNCT
bionys-498	47	1	namely	namely	ADV
bionys-498	47	2	,	,	PUNCT
bionys-498	47	3	egfr	egfr	ADJ
bionys-498	47	4	mutants	mutant	NOUN
bionys-498	47	5	bypass	bypass	VERB
bionys-498	47	6	the	the	DET
bionys-498	47	7	mechanisms	mechanism	NOUN
bionys-498	47	8	that	that	PRON
bionys-498	47	9	initiate	initiate	VERB
bionys-498	47	10	termination	termination	NOUN
bionys-498	47	11	of	of	ADP
bionys-498	47	12	the	the	DET
bionys-498	47	13	signal	signal	ADJ
bionys-498	47	14	transduction	transduction	NOUN
bionys-498	47	15	by	by	ADP
bionys-498	47	16	avoiding	avoid	VERB
bionys-498	47	17	receptor	receptor	NOUN
bionys-498	47	18	endocytosis	endocytosis	NOUN
bionys-498	47	19	and	and	CCONJ
bionys-498	47	20	degradation	degradation	NOUN
bionys-498	47	21	(	(	PUNCT
bionys-498	47	22	mosesson	mosesson	NOUN
bionys-498	47	23	et	et	PROPN
bionys-498	47	24	al	al	PROPN
bionys-498	47	25	.	.	PROPN
bionys-498	47	26	,	,	PUNCT
bionys-498	47	27	2008	2008	NUM
bionys-498	47	28	)	)	PUNCT
bionys-498	47	29	.	.	PUNCT
bionys-498	48	1	studies	study	NOUN
bionys-498	48	2	have	have	AUX
bionys-498	48	3	indicated	indicate	VERB
bionys-498	48	4	that	that	SCONJ
bionys-498	48	5	egfr	egfr	ADJ
bionys-498	48	6	mutations	mutation	NOUN
bionys-498	48	7	not	not	PART
bionys-498	48	8	only	only	ADV
bionys-498	48	9	act	act	VERB
bionys-498	48	10	as	as	ADP
bionys-498	48	11	oncogenic	oncogenic	ADJ
bionys-498	48	12	drivers	driver	NOUN
bionys-498	48	13	of	of	ADP
bionys-498	48	14	crc	crc	NOUN
bionys-498	48	15	but	but	CCONJ
bionys-498	48	16	can	can	AUX
bionys-498	48	17	also	also	ADV
bionys-498	48	18	serve	serve	VERB
bionys-498	48	19	as	as	ADP
bionys-498	48	20	genomic	genomic	ADJ
bionys-498	48	21	predictors	predictor	NOUN
bionys-498	48	22	of	of	ADP
bionys-498	48	23	response	response	NOUN
bionys-498	48	24	to	to	ADP
bionys-498	48	25	anti	anti	ADJ
bionys-498	48	26	-	-	ADJ
bionys-498	48	27	egfr	egfr	ADJ
bionys-498	48	28	therapy	therapy	NOUN
bionys-498	48	29	in	in	ADP
bionys-498	48	30	crc	crc	NOUN
bionys-498	48	31	patients	patient	NOUN
bionys-498	48	32	(	(	PUNCT
bionys-498	48	33	kim	kim	PROPN
bionys-498	48	34	et	et	PROPN
bionys-498	48	35	al	al	PROPN
bionys-498	48	36	.	.	PROPN
bionys-498	48	37	,	,	PUNCT
bionys-498	48	38	2020	2020	NUM
bionys-498	48	39	)	)	PUNCT
bionys-498	48	40	.	.	PUNCT
bionys-498	49	1	having	have	VERB
bionys-498	49	2	in	in	ADP
bionys-498	49	3	mind	mind	NOUN
bionys-498	49	4	such	such	DET
bionys-498	49	5	an	an	DET
bionys-498	49	6	important	important	ADJ
bionys-498	49	7	role	role	NOUN
bionys-498	49	8	of	of	ADP
bionys-498	49	9	egfr	egfr	NOUN
bionys-498	49	10	as	as	ADP
bionys-498	49	11	a	a	DET
bionys-498	49	12	mitogen	mitogen	NOUN
bionys-498	49	13	inducer	inducer	NOUN
bionys-498	49	14	,	,	PUNCT
bionys-498	49	15	the	the	DET
bionys-498	49	16	aim	aim	NOUN
bionys-498	49	17	of	of	ADP
bionys-498	49	18	this	this	DET
bionys-498	49	19	study	study	NOUN
bionys-498	49	20	was	be	AUX
bionys-498	49	21	to	to	PART
bionys-498	49	22	determine	determine	VERB
bionys-498	49	23	the	the	DET
bionys-498	49	24	frequency	frequency	NOUN
bionys-498	49	25	and	and	CCONJ
bionys-498	49	26	type	type	NOUN
bionys-498	49	27	of	of	ADP
bionys-498	49	28	mutations	mutation	NOUN
bionys-498	49	29	in	in	ADP
bionys-498	49	30	the	the	DET
bionys-498	49	31	tyrosine	tyrosine	NOUN
bionys-498	49	32	kinase	kinase	PROPN
bionys-498	49	33	domain	domain	NOUN
bionys-498	49	34	of	of	ADP
bionys-498	49	35	egfr	egfr	NOUN
bionys-498	49	36	in	in	ADP
bionys-498	49	37	starting	start	VERB
bionys-498	49	38	(	(	PUNCT
bionys-498	49	39	t1/	t1/	NOUN
bionys-498	49	40	t2	t2	NOUN
bionys-498	49	41	)	)	PUNCT
bionys-498	49	42	and	and	CCONJ
bionys-498	49	43	final	final	ADJ
bionys-498	49	44	(	(	PUNCT
bionys-498	49	45	t4	t4	PROPN
bionys-498	49	46	)	)	PUNCT
bionys-498	49	47	stages	stage	NOUN
bionys-498	49	48	of	of	ADP
bionys-498	49	49	tumor	tumor	NOUN
bionys-498	49	50	infiltration	infiltration	NOUN
bionys-498	49	51	and	and	CCONJ
bionys-498	49	52	its	its	PRON
bionys-498	49	53	correlation	correlation	NOUN
bionys-498	49	54	with	with	ADP
bionys-498	49	55	clinical	clinical	ADJ
bionys-498	49	56	characteristics	characteristic	NOUN
bionys-498	49	57	of	of	ADP
bionys-498	49	58	patients	patient	NOUN
bionys-498	49	59	with	with	ADP
bionys-498	49	60	crc	crc	NOUN
bionys-498	49	61	on	on	ADP
bionys-498	49	62	the	the	DET
bionys-498	49	63	territory	territory	NOUN
bionys-498	49	64	of	of	ADP
bionys-498	49	65	southeastern	southeastern	ADJ
bionys-498	49	66	serbia	serbia	PROPN
bionys-498	49	67	.	.	PUNCT
bionys-498	50	1	materials	material	NOUN
bionys-498	50	2	and	and	CCONJ
bionys-498	50	3	methods	method	NOUN
bionys-498	50	4	this	this	DET
bionys-498	50	5	study	study	NOUN
bionys-498	50	6	investigated	investigate	VERB
bionys-498	50	7	the	the	DET
bionys-498	50	8	mutational	mutational	ADJ
bionys-498	50	9	status	status	NOUN
bionys-498	50	10	in	in	ADP
bionys-498	50	11	egfr	egfr	NOUN
bionys-498	50	12	of	of	ADP
bionys-498	50	13	38	38	NUM
bionys-498	50	14	crc	crc	NOUN
bionys-498	50	15	patients	patient	NOUN
bionys-498	50	16	.	.	PUNCT
bionys-498	51	1	the	the	DET
bionys-498	51	2	analysis	analysis	NOUN
bionys-498	51	3	was	be	AUX
bionys-498	51	4	performed	perform	VERB
bionys-498	51	5	on	on	ADP
bionys-498	51	6	the	the	DET
bionys-498	51	7	5	5	NUM
bionys-498	51	8	-	-	SYM
bionys-498	51	9	10	10	NUM
bionys-498	51	10	μm	μm	NUM
bionys-498	51	11	thick	thick	ADJ
bionys-498	51	12	formalin	formalin	NOUN
bionys-498	51	13	-	-	PUNCT
bionys-498	51	14	fixed	fix	VERB
bionys-498	51	15	paraffin	paraffin	NOUN
bionys-498	51	16	-	-	PUNCT
bionys-498	51	17	embedded	embed	VERB
bionys-498	51	18	(	(	PUNCT
bionys-498	51	19	ffpe	ffpe	NOUN
bionys-498	51	20	)	)	PUNCT
bionys-498	51	21	sample	sample	NOUN
bionys-498	51	22	tissue	tissue	NOUN
bionys-498	51	23	sections	section	NOUN
bionys-498	51	24	of	of	ADP
bionys-498	51	25	patients	patient	NOUN
bionys-498	51	26	with	with	ADP
bionys-498	51	27	confirmed	confirm	VERB
bionys-498	51	28	crc	crc	NOUN
bionys-498	51	29	who	who	PRON
bionys-498	51	30	were	be	AUX
bionys-498	51	31	referred	refer	VERB
bionys-498	51	32	to	to	ADP
bionys-498	51	33	the	the	DET
bionys-498	51	34	laboratory	laboratory	NOUN
bionys-498	51	35	for	for	ADP
bionys-498	51	36	immunology	immunology	NOUN
bionys-498	51	37	and	and	CCONJ
bionys-498	51	38	genetics	genetic	NOUN
bionys-498	51	39	,	,	PUNCT
bionys-498	51	40	the	the	DET
bionys-498	51	41	center	center	NOUN
bionys-498	51	42	for	for	ADP
bionys-498	51	43	medical	medical	ADJ
bionys-498	51	44	and	and	CCONJ
bionys-498	51	45	clinical	clinical	ADJ
bionys-498	51	46	biochemistry	biochemistry	NOUN
bionys-498	51	47	,	,	PUNCT
bionys-498	51	48	university	university	NOUN
bionys-498	51	49	clinical	clinical	ADJ
bionys-498	51	50	center	center	NOUN
bionys-498	51	51	niš	niš	NOUN
bionys-498	51	52	,	,	PUNCT
bionys-498	51	53	serbia	serbia	PROPN
bionys-498	51	54	during	during	ADP
bionys-498	51	55	20192021	20192021	NUM
bionys-498	51	56	.	.	PUNCT
bionys-498	52	1	ethical	ethical	ADJ
bionys-498	52	2	approval	approval	NOUN
bionys-498	52	3	has	have	AUX
bionys-498	52	4	been	be	AUX
bionys-498	52	5	obtained	obtain	VERB
bionys-498	52	6	from	from	ADP
bionys-498	52	7	the	the	DET
bionys-498	52	8	ethics	ethic	NOUN
bionys-498	52	9	committee	committee	PROPN
bionys-498	52	10	of	of	ADP
bionys-498	52	11	the	the	DET
bionys-498	52	12	clinical	clinical	ADJ
bionys-498	52	13	center	center	NOUN
bionys-498	52	14	,	,	PUNCT
bionys-498	52	15	niš	niš	NOUN
bionys-498	52	16	,	,	PUNCT
bionys-498	52	17	serbia	serbia	PROPN
bionys-498	52	18	no	no	DET
bionys-498	52	19	24722/6	24722/6	NOUN
bionys-498	52	20	.	.	PUNCT
bionys-498	53	1	the	the	DET
bionys-498	53	2	following	follow	VERB
bionys-498	53	3	clinical	clinical	ADJ
bionys-498	53	4	data	datum	NOUN
bionys-498	53	5	were	be	AUX
bionys-498	53	6	collected	collect	VERB
bionys-498	53	7	for	for	ADP
bionys-498	53	8	each	each	DET
bionys-498	53	9	patient	patient	NOUN
bionys-498	53	10	:	:	PUNCT
bionys-498	53	11	sex	sex	NOUN
bionys-498	53	12	,	,	PUNCT
bionys-498	53	13	age	age	NOUN
bionys-498	53	14	,	,	PUNCT
bionys-498	53	15	tumor	tumor	NOUN
bionys-498	53	16	location	location	NOUN
bionys-498	53	17	.	.	PUNCT
bionys-498	54	1	stage	stage	NOUN
bionys-498	54	2	of	of	ADP
bionys-498	54	3	tumor	tumor	NOUN
bionys-498	54	4	infiltration	infiltration	NOUN
bionys-498	54	5	,	,	PUNCT
bionys-498	54	6	nodal	nodal	NOUN
bionys-498	54	7	status	status	NOUN
bionys-498	54	8	,	,	PUNCT
bionys-498	54	9	and	and	CCONJ
bionys-498	54	10	the	the	DET
bionys-498	54	11	presence	presence	NOUN
bionys-498	54	12	of	of	ADP
bionys-498	54	13	distant	distant	ADJ
bionys-498	54	14	metastases	metastasis	NOUN
bionys-498	54	15	.	.	PUNCT
bionys-498	55	1	the	the	DET
bionys-498	55	2	stage	stage	NOUN
bionys-498	55	3	of	of	ADP
bionys-498	55	4	the	the	DET
bionys-498	55	5	tumor	tumor	NOUN
bionys-498	55	6	was	be	AUX
bionys-498	55	7	determined	determine	VERB
bionys-498	55	8	in	in	ADP
bionys-498	55	9	accordance	accordance	NOUN
bionys-498	55	10	with	with	ADP
bionys-498	55	11	tumor	tumor	NOUN
bionys-498	55	12	-	-	PUNCT
bionys-498	55	13	nodes	node	NOUN
bionys-498	55	14	-	-	PUNCT
bionys-498	55	15	metastasis	metastasis	NOUN
bionys-498	55	16	(	(	PUNCT
bionys-498	55	17	tnm	tnm	NOUN
bionys-498	55	18	)	)	PUNCT
bionys-498	55	19	classificational	classificational	ADJ
bionys-498	55	20	system	system	NOUN
bionys-498	55	21	recommended	recommend	VERB
bionys-498	55	22	by	by	ADP
bionys-498	55	23	the	the	DET
bionys-498	55	24	american	american	PROPN
bionys-498	55	25	joint	joint	PROPN
bionys-498	55	26	committee	committee	PROPN
bionys-498	55	27	on	on	ADP
bionys-498	55	28	cancer	cancer	NOUN
bionys-498	55	29	staging	staging	NOUN
bionys-498	55	30	system	system	NOUN
bionys-498	55	31	(	(	PUNCT
bionys-498	55	32	ajcc	ajcc	PROPN
bionys-498	55	33	)	)	PUNCT
bionys-498	55	34	,	,	PUNCT
bionys-498	55	35	where	where	SCONJ
bionys-498	55	36	t1	t1	NOUN
bionys-498	55	37	and	and	CCONJ
bionys-498	55	38	t2	t2	NOUN
bionys-498	55	39	denote	denote	NOUN
bionys-498	55	40	starting	start	VERB
bionys-498	55	41	stages	stage	NOUN
bionys-498	55	42	(	(	PUNCT
bionys-498	55	43	t1	t1	NOUN
bionys-498	55	44	,	,	PUNCT
bionys-498	55	45	when	when	SCONJ
bionys-498	55	46	tumor	tumor	NOUN
bionys-498	55	47	invades	invade	VERB
bionys-498	55	48	submucosa	submucosa	NOUN
bionys-498	55	49	,	,	PUNCT
bionys-498	55	50	and	and	CCONJ
bionys-498	55	51	t2	t2	NOUN
bionys-498	55	52	,	,	PUNCT
bionys-498	55	53	when	when	SCONJ
bionys-498	55	54	tumor	tumor	NOUN
bionys-498	55	55	invades	invade	VERB
bionys-498	55	56	muscularis	muscularis	PROPN
bionys-498	55	57	propria	propria	PROPN
bionys-498	55	58	)	)	PUNCT
bionys-498	55	59	and	and	CCONJ
bionys-498	55	60	t4	t4	PROPN
bionys-498	55	61	denotes	denote	VERB
bionys-498	55	62	the	the	DET
bionys-498	55	63	final	final	ADJ
bionys-498	55	64	stage	stage	NOUN
bionys-498	55	65	of	of	ADP
bionys-498	55	66	tumor	tumor	NOUN
bionys-498	55	67	infiltration	infiltration	NOUN
bionys-498	55	68	,	,	PUNCT
bionys-498	55	69	when	when	SCONJ
bionys-498	55	70	tumor	tumor	NOUN
bionys-498	55	71	perforates	perforate	VERB
bionys-498	55	72	visceral	visceral	ADJ
bionys-498	55	73	peritoneum	peritoneum	NOUN
bionys-498	55	74	and/or	and/or	CCONJ
bionys-498	55	75	directly	directly	ADV
bionys-498	55	76	40	40	NUM
bionys-498	55	77	biologica	biologica	PROPN
bionys-498	55	78	nyssana	nyssana	PROPN
bionys-498	55	79	●	●	PUNCT
bionys-498	55	80	14	14	NUM
bionys-498	55	81	(	(	PUNCT
bionys-498	55	82	1	1	NUM
bionys-498	55	83	)	)	PUNCT
bionys-498	55	84	june	june	PROPN
bionys-498	55	85	2023	2023	NUM
bionys-498	55	86	:	:	PUNCT
bionys-498	55	87	39	39	NUM
bionys-498	55	88	-	-	SYM
bionys-498	55	89	46	46	NUM
bionys-498	55	90	jugović	jugović	NOUN
bionys-498	55	91	et	et	PROPN
bionys-498	55	92	al	al	PROPN
bionys-498	55	93	.	.	PUNCT
bionys-498	56	1	●	●	PUNCT
bionys-498	56	2	the	the	DET
bionys-498	56	3	frequency	frequency	NOUN
bionys-498	56	4	and	and	CCONJ
bionys-498	56	5	type	type	NOUN
bionys-498	56	6	of	of	ADP
bionys-498	56	7	mutations	mutation	NOUN
bionys-498	56	8	in	in	ADP
bionys-498	56	9	the	the	DET
bionys-498	56	10	egfr	egfr	ADJ
bionys-498	56	11	gene	gene	NOUN
bionys-498	56	12	of	of	ADP
bionys-498	56	13	colorectal	colorectal	ADJ
bionys-498	56	14	carcinoma	carcinoma	NOUN
bionys-498	56	15	patients	patient	NOUN
bionys-498	56	16	in	in	ADP
bionys-498	56	17	southeastern	southeastern	ADJ
bionys-498	56	18	serbia	serbia	PROPN
bionys-498	56	19	biologica	biologica	PROPN
bionys-498	56	20	nyssana	nyssana	PROPN
bionys-498	56	21	●	●	PUNCT
bionys-498	56	22	14	14	NUM
bionys-498	56	23	(	(	PUNCT
bionys-498	56	24	1	1	NUM
bionys-498	56	25	)	)	PUNCT
bionys-498	56	26	june	june	PROPN
bionys-498	56	27	2023	2023	NUM
bionys-498	56	28	:	:	PUNCT
bionys-498	56	29	39	39	NUM
bionys-498	56	30	-	-	SYM
bionys-498	56	31	46	46	NUM
bionys-498	56	32	jugović	jugović	NOUN
bionys-498	56	33	et	et	PROPN
bionys-498	56	34	al	al	PROPN
bionys-498	56	35	.	.	PUNCT
bionys-498	57	1	●	●	PUNCT
bionys-498	57	2	the	the	DET
bionys-498	57	3	frequency	frequency	NOUN
bionys-498	57	4	and	and	CCONJ
bionys-498	57	5	type	type	NOUN
bionys-498	57	6	of	of	ADP
bionys-498	57	7	mutations	mutation	NOUN
bionys-498	57	8	in	in	ADP
bionys-498	57	9	the	the	DET
bionys-498	57	10	egfr	egfr	ADJ
bionys-498	57	11	gene	gene	NOUN
bionys-498	57	12	of	of	ADP
bionys-498	57	13	colorectal	colorectal	ADJ
bionys-498	57	14	carcinoma	carcinoma	NOUN
bionys-498	57	15	patients	patient	NOUN
bionys-498	57	16	in	in	ADP
bionys-498	57	17	southeastern	southeastern	ADJ
bionys-498	57	18	serbia	serbia	PROPN
bionys-498	57	19	41	41	NUM
bionys-498	57	20	following	follow	VERB
bionys-498	57	21	cycling	cycling	NOUN
bionys-498	57	22	conditions	condition	NOUN
bionys-498	57	23	initial	initial	ADJ
bionys-498	57	24	denaturation	denaturation	NOUN
bionys-498	57	25	step	step	NOUN
bionys-498	57	26	at	at	ADP
bionys-498	57	27	95	95	NUM
bionys-498	57	28	°	°	ADP
bionys-498	57	29	c	c	NOUN
bionys-498	57	30	for	for	ADP
bionys-498	57	31	2	2	NUM
bionys-498	57	32	min	min	NOUN
bionys-498	57	33	,	,	PUNCT
bionys-498	57	34	then	then	ADV
bionys-498	57	35	running	run	VERB
bionys-498	57	36	40	40	NUM
bionys-498	57	37	cycles	cycle	NOUN
bionys-498	57	38	of	of	ADP
bionys-498	57	39	95	95	NUM
bionys-498	57	40	°	°	ADP
bionys-498	57	41	c	c	NOUN
bionys-498	57	42	for	for	ADP
bionys-498	57	43	10	10	NUM
bionys-498	57	44	seconds/58	seconds/58	NOUN
bionys-498	57	45	°	°	ADP
bionys-498	57	46	c	c	NOUN
bionys-498	57	47	for	for	ADP
bionys-498	57	48	60	60	NUM
bionys-498	57	49	seconds	second	NOUN
bionys-498	57	50	.	.	PUNCT
bionys-498	58	1	the	the	DET
bionys-498	58	2	mutation	mutation	NOUN
bionys-498	58	3	analysis	analysis	NOUN
bionys-498	58	4	was	be	AUX
bionys-498	58	5	carried	carry	VERB
bionys-498	58	6	out	out	ADP
bionys-498	58	7	in	in	ADP
bionys-498	58	8	relation	relation	NOUN
bionys-498	58	9	to	to	ADP
bionys-498	58	10	the	the	DET
bionys-498	58	11	amplification	amplification	NOUN
bionys-498	58	12	of	of	ADP
bionys-498	58	13	positive	positive	ADJ
bionys-498	58	14	and	and	CCONJ
bionys-498	58	15	negative	negative	ADJ
bionys-498	58	16	control	control	NOUN
bionys-498	58	17	tests	test	NOUN
bionys-498	58	18	provided	provide	VERB
bionys-498	58	19	by	by	ADP
bionys-498	58	20	the	the	DET
bionys-498	58	21	manufacturer	manufacturer	NOUN
bionys-498	58	22	and	and	CCONJ
bionys-498	58	23	according	accord	VERB
bionys-498	58	24	to	to	ADP
bionys-498	58	25	the	the	DET
bionys-498	58	26	included	include	VERB
bionys-498	58	27	protocol	protocol	NOUN
bionys-498	58	28	.	.	PUNCT
bionys-498	59	1	statistical	statistical	ADJ
bionys-498	59	2	analysis	analysis	NOUN
bionys-498	59	3	statistical	statistical	ADJ
bionys-498	59	4	analysis	analysis	NOUN
bionys-498	59	5	was	be	AUX
bionys-498	59	6	done	do	VERB
bionys-498	59	7	using	use	VERB
bionys-498	59	8	microsoft	microsoft	PROPN
bionys-498	59	9	excel	excel	PROPN
bionys-498	59	10	2010	2010	NUM
bionys-498	59	11	(	(	PUNCT
bionys-498	59	12	microsoft	microsoft	PROPN
bionys-498	59	13	corporation	corporation	PROPN
bionys-498	59	14	,	,	PUNCT
bionys-498	59	15	usa	usa	PROPN
bionys-498	59	16	)	)	PUNCT
bionys-498	59	17	.	.	PUNCT
bionys-498	60	1	results	result	NOUN
bionys-498	60	2	of	of	ADP
bionys-498	60	3	egfr	egfr	ADJ
bionys-498	60	4	mutational	mutational	ADJ
bionys-498	60	5	analysis	analysis	NOUN
bionys-498	60	6	were	be	AUX
bionys-498	60	7	used	use	VERB
bionys-498	60	8	as	as	ADP
bionys-498	60	9	categorical	categorical	ADJ
bionys-498	60	10	variables	variable	NOUN
bionys-498	60	11	(	(	PUNCT
bionys-498	60	12	presence	presence	NOUN
bionys-498	60	13	or	or	CCONJ
bionys-498	60	14	absence	absence	NOUN
bionys-498	60	15	of	of	ADP
bionys-498	60	16	the	the	DET
bionys-498	60	17	mutation	mutation	NOUN
bionys-498	60	18	)	)	PUNCT
bionys-498	60	19	.	.	PUNCT
bionys-498	61	1	comparison	comparison	NOUN
bionys-498	61	2	between	between	ADP
bionys-498	61	3	clinical	clinical	ADJ
bionys-498	61	4	characteristics	characteristic	NOUN
bionys-498	61	5	and	and	CCONJ
bionys-498	61	6	mutational	mutational	ADJ
bionys-498	61	7	status	status	NOUN
bionys-498	61	8	was	be	AUX
bionys-498	61	9	done	do	VERB
bionys-498	61	10	using	use	VERB
bionys-498	61	11	fisher	fisher	PROPN
bionys-498	61	12	’s	’s	PART
bionys-498	61	13	exact	exact	ADJ
bionys-498	61	14	test	test	NOUN
bionys-498	61	15	or	or	CCONJ
bionys-498	61	16	χ2	χ2	PROPN
bionys-498	61	17	test	test	NOUN
bionys-498	61	18	where	where	SCONJ
bionys-498	61	19	appropriate	appropriate	ADJ
bionys-498	61	20	.	.	PUNCT
bionys-498	62	1	statistical	statistical	ADJ
bionys-498	62	2	significance	significance	NOUN
bionys-498	62	3	was	be	AUX
bionys-498	62	4	accepted	accept	VERB
bionys-498	62	5	if	if	SCONJ
bionys-498	62	6	p<0.05	p<0.05	PROPN
bionys-498	62	7	.	.	PUNCT
bionys-498	63	1	results	result	VERB
bionys-498	63	2	this	this	DET
bionys-498	63	3	study	study	NOUN
bionys-498	63	4	included	include	VERB
bionys-498	63	5	samples	sample	NOUN
bionys-498	63	6	of	of	ADP
bionys-498	63	7	38	38	NUM
bionys-498	63	8	patients	patient	NOUN
bionys-498	63	9	with	with	ADP
bionys-498	63	10	crc	crc	NOUN
bionys-498	63	11	,	,	PUNCT
bionys-498	63	12	collected	collect	VERB
bionys-498	63	13	during	during	ADP
bionys-498	63	14	2019	2019	NUM
bionys-498	63	15	-	-	SYM
bionys-498	63	16	2021	2021	NUM
bionys-498	63	17	.	.	PUNCT
bionys-498	64	1	there	there	PRON
bionys-498	64	2	were	be	VERB
bionys-498	64	3	24	24	NUM
bionys-498	64	4	male	male	ADJ
bionys-498	64	5	and	and	CCONJ
bionys-498	64	6	14	14	NUM
bionys-498	64	7	female	female	ADJ
bionys-498	64	8	patients	patient	NOUN
bionys-498	64	9	,	,	PUNCT
bionys-498	64	10	aged	age	VERB
bionys-498	64	11	from	from	ADP
bionys-498	64	12	42	42	NUM
bionys-498	64	13	to	to	PART
bionys-498	64	14	79	79	NUM
bionys-498	64	15	years	year	NOUN
bionys-498	64	16	(	(	PUNCT
bionys-498	64	17	tab	tab	NOUN
bionys-498	64	18	.	.	NOUN
bionys-498	64	19	1	1	NUM
bionys-498	64	20	)	)	PUNCT
bionys-498	64	21	.	.	PUNCT
bionys-498	65	1	of	of	ADP
bionys-498	65	2	all	all	DET
bionys-498	65	3	38	38	NUM
bionys-498	65	4	tested	test	VERB
bionys-498	65	5	patients	patient	NOUN
bionys-498	65	6	,	,	PUNCT
bionys-498	65	7	35	35	NUM
bionys-498	65	8	of	of	ADP
bionys-498	65	9	them	they	PRON
bionys-498	65	10	(	(	PUNCT
bionys-498	65	11	92.1	92.1	NUM
bionys-498	65	12	%	%	NOUN
bionys-498	65	13	)	)	PUNCT
bionys-498	65	14	did	do	AUX
bionys-498	65	15	not	not	PART
bionys-498	65	16	have	have	VERB
bionys-498	65	17	any	any	DET
bionys-498	65	18	detectable	detectable	ADJ
bionys-498	65	19	mutations	mutation	NOUN
bionys-498	65	20	in	in	ADP
bionys-498	65	21	the	the	DET
bionys-498	65	22	egfr	egfr	NOUN
bionys-498	65	23	.	.	PUNCT
bionys-498	66	1	egfr	egfr	ADJ
bionys-498	66	2	mutations	mutation	NOUN
bionys-498	66	3	(	(	PUNCT
bionys-498	66	4	g719x	g719x	NOUN
bionys-498	66	5	)	)	PUNCT
bionys-498	66	6	were	be	AUX
bionys-498	66	7	observed	observe	VERB
bionys-498	66	8	in	in	ADP
bionys-498	66	9	exon	exon	NOUN
bionys-498	66	10	18	18	NUM
bionys-498	66	11	in	in	ADP
bionys-498	66	12	3	3	NUM
bionys-498	66	13	(	(	PUNCT
bionys-498	66	14	7.9	7.9	NUM
bionys-498	66	15	%	%	NOUN
bionys-498	66	16	)	)	PUNCT
bionys-498	66	17	patients	patient	NOUN
bionys-498	66	18	.	.	PUNCT
bionys-498	67	1	the	the	DET
bionys-498	67	2	g719x	g719x	NOUN
bionys-498	67	3	mutation	mutation	NOUN
bionys-498	67	4	in	in	ADP
bionys-498	67	5	egfr	egfr	NOUN
bionys-498	67	6	refers	refer	VERB
bionys-498	67	7	to	to	PART
bionys-498	67	8	point	point	VERB
bionys-498	67	9	mutations	mutation	NOUN
bionys-498	67	10	that	that	PRON
bionys-498	67	11	result	result	VERB
bionys-498	67	12	in	in	ADP
bionys-498	67	13	substitutions	substitution	NOUN
bionys-498	67	14	of	of	ADP
bionys-498	67	15	the	the	DET
bionys-498	67	16	glycine	glycine	NOUN
bionys-498	67	17	at	at	ADP
bionys-498	67	18	position	position	NOUN
bionys-498	67	19	719	719	NUM
bionys-498	67	20	to	to	ADP
bionys-498	67	21	other	other	ADJ
bionys-498	67	22	residues	residue	NOUN
bionys-498	67	23	,	,	PUNCT
bionys-498	67	24	primarily	primarily	ADV
bionys-498	67	25	alanine	alanine	NOUN
bionys-498	67	26	(	(	PUNCT
bionys-498	67	27	g719a	g719a	PROPN
bionys-498	67	28	)	)	PUNCT
bionys-498	67	29	,	,	PUNCT
bionys-498	67	30	cysteine	cysteine	NOUN
bionys-498	67	31	(	(	PUNCT
bionys-498	67	32	g719c	g719c	PROPN
bionys-498	67	33	)	)	PUNCT
bionys-498	67	34	,	,	PUNCT
bionys-498	67	35	and	and	CCONJ
bionys-498	67	36	serine	serine	NOUN
bionys-498	67	37	(	(	PUNCT
bionys-498	67	38	g719s	g719s	PROPN
bionys-498	67	39	)	)	PUNCT
bionys-498	67	40	(	(	PUNCT
bionys-498	67	41	fig	fig	NOUN
bionys-498	67	42	.	.	PUNCT
bionys-498	68	1	1	1	NUM
bionys-498	68	2	)	)	PUNCT
bionys-498	68	3	.	.	PUNCT
bionys-498	69	1	no	no	DET
bionys-498	69	2	mutations	mutation	NOUN
bionys-498	69	3	were	be	AUX
bionys-498	69	4	detected	detect	VERB
bionys-498	69	5	in	in	ADP
bionys-498	69	6	exons	exon	NOUN
bionys-498	69	7	19	19	NUM
bionys-498	69	8	,	,	PUNCT
bionys-498	69	9	20	20	NUM
bionys-498	69	10	,	,	PUNCT
bionys-498	69	11	and	and	CCONJ
bionys-498	69	12	21	21	NUM
bionys-498	69	13	.	.	PUNCT
bionys-498	70	1	two	two	NUM
bionys-498	70	2	out	out	ADP
bionys-498	70	3	of	of	ADP
bionys-498	70	4	the	the	DET
bionys-498	70	5	three	three	NUM
bionys-498	70	6	patients	patient	NOUN
bionys-498	70	7	with	with	ADP
bionys-498	70	8	detected	detect	VERB
bionys-498	70	9	mutations	mutation	NOUN
bionys-498	70	10	have	have	VERB
bionys-498	70	11	the	the	DET
bionys-498	70	12	t2	t2	NOUN
bionys-498	70	13	stage	stage	NOUN
bionys-498	70	14	of	of	ADP
bionys-498	70	15	crc	crc	NOUN
bionys-498	70	16	,	,	PUNCT
bionys-498	70	17	located	locate	VERB
bionys-498	70	18	in	in	ADP
bionys-498	70	19	the	the	DET
bionys-498	70	20	left	left	ADJ
bionys-498	70	21	colon	colon	NOUN
bionys-498	70	22	,	,	PUNCT
bionys-498	70	23	and	and	CCONJ
bionys-498	70	24	with	with	ADP
bionys-498	70	25	no	no	DET
bionys-498	70	26	metastases	metastasis	NOUN
bionys-498	70	27	in	in	ADP
bionys-498	70	28	lymph	lymph	NOUN
bionys-498	70	29	nodes	node	NOUN
bionys-498	70	30	.	.	PUNCT
bionys-498	71	1	the	the	DET
bionys-498	71	2	third	third	ADJ
bionys-498	71	3	case	case	NOUN
bionys-498	71	4	was	be	AUX
bionys-498	71	5	a	a	DET
bionys-498	71	6	patient	patient	NOUN
bionys-498	71	7	with	with	ADP
bionys-498	71	8	the	the	DET
bionys-498	71	9	t4	t4	PROPN
bionys-498	71	10	stage	stage	NOUN
bionys-498	71	11	of	of	ADP
bionys-498	71	12	the	the	DET
bionys-498	71	13	tumour	tumour	NOUN
bionys-498	71	14	,	,	PUNCT
bionys-498	71	15	located	locate	VERB
bionys-498	71	16	in	in	ADP
bionys-498	71	17	the	the	DET
bionys-498	71	18	right	right	ADJ
bionys-498	71	19	colon	colon	NOUN
bionys-498	71	20	and	and	CCONJ
bionys-498	71	21	with	with	ADP
bionys-498	71	22	metastases	metastasis	NOUN
bionys-498	71	23	in	in	ADP
bionys-498	71	24	lymph	lymph	NOUN
bionys-498	71	25	nodes	node	NOUN
bionys-498	71	26	.	.	PUNCT
bionys-498	72	1	mutation	mutation	NOUN
bionys-498	72	2	in	in	ADP
bionys-498	72	3	egfr	egfr	NOUN
bionys-498	72	4	(	(	PUNCT
bionys-498	72	5	g719x	g719x	NOUN
bionys-498	72	6	)	)	PUNCT
bionys-498	72	7	was	be	AUX
bionys-498	72	8	detected	detect	VERB
bionys-498	72	9	in	in	ADP
bionys-498	72	10	one	one	NUM
bionys-498	72	11	patient	patient	NOUN
bionys-498	72	12	with	with	ADP
bionys-498	72	13	distant	distant	ADJ
bionys-498	72	14	metastases	metastasis	NOUN
bionys-498	72	15	in	in	ADP
bionys-498	72	16	the	the	DET
bionys-498	72	17	lungs	lung	NOUN
bionys-498	72	18	,	,	PUNCT
bionys-498	72	19	one	one	NUM
bionys-498	72	20	patient	patient	NOUN
bionys-498	72	21	with	with	ADP
bionys-498	72	22	distant	distant	ADJ
bionys-498	72	23	metastases	metastasis	NOUN
bionys-498	72	24	in	in	ADP
bionys-498	72	25	both	both	DET
bionys-498	72	26	lungs	lung	NOUN
bionys-498	72	27	and	and	CCONJ
bionys-498	72	28	liver	liver	NOUN
bionys-498	72	29	,	,	PUNCT
bionys-498	72	30	and	and	CCONJ
bionys-498	72	31	in	in	ADP
bionys-498	72	32	one	one	NUM
bionys-498	72	33	patient	patient	NOUN
bionys-498	72	34	with	with	ADP
bionys-498	72	35	distant	distant	ADJ
bionys-498	72	36	metastases	metastasis	NOUN
bionys-498	72	37	in	in	ADP
bionys-498	72	38	the	the	DET
bionys-498	72	39	pelvis	pelvis	NOUN
bionys-498	72	40	.	.	PUNCT
bionys-498	73	1	there	there	PRON
bionys-498	73	2	was	be	VERB
bionys-498	73	3	no	no	DET
bionys-498	73	4	statistically	statistically	ADV
bionys-498	73	5	significant	significant	ADJ
bionys-498	73	6	correlation	correlation	NOUN
bionys-498	73	7	between	between	ADP
bionys-498	73	8	the	the	DET
bionys-498	73	9	mutational	mutational	ADJ
bionys-498	73	10	status	status	NOUN
bionys-498	73	11	in	in	ADP
bionys-498	73	12	the	the	DET
bionys-498	73	13	egfr	egfr	NOUN
bionys-498	73	14	and	and	CCONJ
bionys-498	73	15	the	the	DET
bionys-498	73	16	clinical	clinical	ADJ
bionys-498	73	17	characteristics	characteristic	NOUN
bionys-498	73	18	of	of	ADP
bionys-498	73	19	patients	patient	NOUN
bionys-498	73	20	(	(	PUNCT
bionys-498	73	21	tab	tab	NOUN
bionys-498	73	22	.	.	NOUN
bionys-498	73	23	1	1	NUM
bionys-498	73	24	)	)	PUNCT
bionys-498	73	25	.	.	PUNCT
bionys-498	74	1	discussion	discussion	NOUN
bionys-498	74	2	in	in	ADP
bionys-498	74	3	serbia	serbia	PROPN
bionys-498	74	4	,	,	PUNCT
bionys-498	74	5	colorectal	colorectal	ADJ
bionys-498	74	6	carcinoma	carcinoma	NOUN
bionys-498	74	7	is	be	AUX
bionys-498	74	8	the	the	DET
bionys-498	74	9	third	third	ADJ
bionys-498	74	10	most	most	ADV
bionys-498	74	11	common	common	ADJ
bionys-498	74	12	cancer	cancer	NOUN
bionys-498	74	13	,	,	PUNCT
bionys-498	74	14	as	as	ADV
bionys-498	74	15	well	well	ADV
bionys-498	74	16	as	as	ADP
bionys-498	74	17	the	the	DET
bionys-498	74	18	second	second	ADJ
bionys-498	74	19	most	most	ADV
bionys-498	74	20	common	common	ADJ
bionys-498	74	21	cause	cause	NOUN
bionys-498	74	22	of	of	ADP
bionys-498	74	23	cancer	cancer	NOUN
bionys-498	74	24	-	-	PUNCT
bionys-498	74	25	related	relate	VERB
bionys-498	74	26	death	death	NOUN
bionys-498	74	27	,	,	PUNCT
bionys-498	74	28	right	right	ADV
bionys-498	74	29	after	after	ADP
bionys-498	74	30	lung	lung	NOUN
bionys-498	74	31	cancer	cancer	NOUN
bionys-498	74	32	(	(	PUNCT
bionys-498	74	33	ferlay	ferlay	NOUN
bionys-498	74	34	et	et	PROPN
bionys-498	74	35	al	al	PROPN
bionys-498	74	36	.	.	PROPN
bionys-498	74	37	,	,	PUNCT
bionys-498	74	38	2020	2020	NUM
bionys-498	74	39	)	)	PUNCT
bionys-498	74	40	.	.	PUNCT
bionys-498	75	1	namely	namely	ADV
bionys-498	75	2	,	,	PUNCT
bionys-498	75	3	according	accord	VERB
bionys-498	75	4	to	to	ADP
bionys-498	75	5	the	the	DET
bionys-498	75	6	cancer	cancer	NOUN
bionys-498	75	7	register	register	NOUN
bionys-498	75	8	for	for	ADP
bionys-498	75	9	republic	republic	NOUN
bionys-498	75	10	of	of	ADP
bionys-498	75	11	serbia	serbia	PROPN
bionys-498	75	12	,	,	PUNCT
bionys-498	75	13	there	there	PRON
bionys-498	75	14	were	be	VERB
bionys-498	75	15	even	even	ADV
bionys-498	75	16	4646	4646	NUM
bionys-498	75	17	new	new	ADJ
bionys-498	75	18	crc	crc	NOUN
bionys-498	75	19	cases	case	NOUN
bionys-498	75	20	registered	register	VERB
bionys-498	75	21	in	in	ADP
bionys-498	75	22	serbia	serbia	PROPN
bionys-498	75	23	in	in	ADP
bionys-498	75	24	2018	2018	NUM
bionys-498	75	25	.	.	PUNCT
bionys-498	76	1	more	more	ADJ
bionys-498	76	2	than	than	ADP
bionys-498	76	3	a	a	DET
bionys-498	76	4	thousand	thousand	NUM
bionys-498	76	5	of	of	ADP
bionys-498	76	6	these	these	DET
bionys-498	76	7	new	new	ADJ
bionys-498	76	8	crc	crc	NOUN
bionys-498	76	9	cases	case	NOUN
bionys-498	76	10	invades	invade	VERB
bionys-498	76	11	other	other	ADJ
bionys-498	76	12	organs	organ	NOUN
bionys-498	76	13	or	or	CCONJ
bionys-498	76	14	structures	structure	NOUN
bionys-498	76	15	(	(	PUNCT
bionys-498	76	16	tong	tong	NOUN
bionys-498	76	17	et	et	PROPN
bionys-498	76	18	al	al	PROPN
bionys-498	76	19	.	.	PROPN
bionys-498	76	20	,	,	PUNCT
bionys-498	76	21	2018	2018	NUM
bionys-498	76	22	)	)	PUNCT
bionys-498	76	23	.	.	PUNCT
bionys-498	77	1	according	accord	VERB
bionys-498	77	2	to	to	ADP
bionys-498	77	3	the	the	DET
bionys-498	77	4	location	location	NOUN
bionys-498	77	5	,	,	PUNCT
bionys-498	77	6	the	the	DET
bionys-498	77	7	tumors	tumor	NOUN
bionys-498	77	8	were	be	AUX
bionys-498	77	9	divided	divide	VERB
bionys-498	77	10	into	into	ADP
bionys-498	77	11	the	the	DET
bionys-498	77	12	left	left	ADJ
bionys-498	77	13	-	-	PUNCT
bionys-498	77	14	sided	sided	ADJ
bionys-498	77	15	colon	colon	NOUN
bionys-498	77	16	(	(	PUNCT
bionys-498	77	17	lcc	lcc	PROPN
bionys-498	77	18	)	)	PUNCT
bionys-498	77	19	and	and	CCONJ
bionys-498	77	20	rightsided	rightside	VERB
bionys-498	77	21	colon	colon	NOUN
bionys-498	77	22	(	(	PUNCT
bionys-498	77	23	rcc	rcc	PROPN
bionys-498	77	24	)	)	PUNCT
bionys-498	77	25	.	.	PUNCT
bionys-498	78	1	lcc	lcc	PROPN
bionys-498	78	2	included	include	VERB
bionys-498	78	3	splenic	splenic	ADJ
bionys-498	78	4	flexure	flexure	NOUN
bionys-498	78	5	,	,	PUNCT
bionys-498	78	6	descending	descend	VERB
bionys-498	78	7	colon	colon	NOUN
bionys-498	78	8	,	,	PUNCT
bionys-498	78	9	sigmoid	sigmoid	NOUN
bionys-498	78	10	,	,	PUNCT
bionys-498	78	11	and	and	CCONJ
bionys-498	78	12	rectum	rectum	NOUN
bionys-498	78	13	,	,	PUNCT
bionys-498	78	14	while	while	SCONJ
bionys-498	78	15	the	the	DET
bionys-498	78	16	rcc	rcc	PROPN
bionys-498	78	17	included	include	VERB
bionys-498	78	18	caecum	caecum	NOUN
bionys-498	78	19	,	,	PUNCT
bionys-498	78	20	ascending	ascend	VERB
bionys-498	78	21	colon	colon	NOUN
bionys-498	78	22	,	,	PUNCT
bionys-498	78	23	hepatic	hepatic	ADJ
bionys-498	78	24	flexure	flexure	NOUN
bionys-498	78	25	,	,	PUNCT
bionys-498	78	26	and	and	CCONJ
bionys-498	78	27	transverse	transverse	NOUN
bionys-498	78	28	colon	colon	NOUN
bionys-498	78	29	.	.	PUNCT
bionys-498	79	1	dna	dna	PROPN
bionys-498	79	2	isolation	isolation	NOUN
bionys-498	79	3	genomic	genomic	NOUN
bionys-498	79	4	dna	dna	NOUN
bionys-498	79	5	was	be	AUX
bionys-498	79	6	extracted	extract	VERB
bionys-498	79	7	from	from	ADP
bionys-498	79	8	the	the	DET
bionys-498	79	9	ffpe	ffpe	ADJ
bionys-498	79	10	tumour	tumour	NOUN
bionys-498	79	11	tissue	tissue	NOUN
bionys-498	79	12	sections	section	NOUN
bionys-498	79	13	using	use	VERB
bionys-498	79	14	a	a	DET
bionys-498	79	15	qiaamp	qiaamp	ADJ
bionys-498	79	16	dna	dna	PROPN
bionys-498	79	17	ffpe	ffpe	NOUN
bionys-498	79	18	tissue	tissue	NOUN
bionys-498	79	19	kit	kit	NOUN
bionys-498	79	20	(	(	PUNCT
bionys-498	79	21	ce	ce	PROPN
bionys-498	79	22	-	-	PUNCT
bionys-498	79	23	ivd	ivd	NOUN
bionys-498	79	24	-	-	PUNCT
bionys-498	79	25	marked	mark	VERB
bionys-498	79	26	;	;	PUNCT
bionys-498	79	27	qiagen	qiagen	PROPN
bionys-498	79	28	,	,	PUNCT
bionys-498	79	29	hilden	hilden	NOUN
bionys-498	79	30	,	,	PUNCT
bionys-498	79	31	ger	ger	NOUN
bionys-498	79	32	many	many	ADJ
bionys-498	79	33	)	)	PUNCT
bionys-498	79	34	,	,	PUNCT
bionys-498	79	35	according	accord	VERB
bionys-498	79	36	to	to	ADP
bionys-498	79	37	the	the	DET
bionys-498	79	38	manufacturer	manufacturer	NOUN
bionys-498	79	39	’s	’s	PART
bionys-498	79	40	protocol	protocol	NOUN
bionys-498	79	41	.	.	PUNCT
bionys-498	80	1	the	the	DET
bionys-498	80	2	dna	dna	PROPN
bionys-498	80	3	quality	quality	NOUN
bionys-498	80	4	was	be	AUX
bionys-498	80	5	determined	determine	VERB
bionys-498	80	6	with	with	ADP
bionys-498	80	7	260/280	260/280	NUM
bionys-498	80	8	optical	optical	ADJ
bionys-498	80	9	density	density	NOUN
bionys-498	80	10	(	(	PUNCT
bionys-498	80	11	od	od	NOUN
bionys-498	80	12	)	)	PUNCT
bionys-498	80	13	ratios	ratio	NOUN
bionys-498	80	14	in	in	ADP
bionys-498	80	15	all	all	DET
bionys-498	80	16	samples	sample	NOUN
bionys-498	80	17	,	,	PUNCT
bionys-498	80	18	which	which	PRON
bionys-498	80	19	were	be	AUX
bionys-498	80	20	stored	store	VERB
bionys-498	80	21	at	at	ADP
bionys-498	80	22	-20	-20	NUM
bionys-498	80	23	°	°	NOUN
bionys-498	80	24	c	c	NOUN
bionys-498	80	25	until	until	ADP
bionys-498	80	26	use	use	NOUN
bionys-498	80	27	.	.	PUNCT
bionys-498	81	1	real	real	ADJ
bionys-498	81	2	-	-	PUNCT
bionys-498	81	3	time	time	NOUN
bionys-498	81	4	pcr	pcr	NOUN
bionys-498	81	5	the	the	DET
bionys-498	81	6	analysis	analysis	NOUN
bionys-498	81	7	of	of	ADP
bionys-498	81	8	the	the	DET
bionys-498	81	9	egfr	egfr	ADJ
bionys-498	81	10	mutation	mutation	NOUN
bionys-498	81	11	was	be	AUX
bionys-498	81	12	performed	perform	VERB
bionys-498	81	13	using	use	VERB
bionys-498	81	14	the	the	DET
bionys-498	81	15	„	„	PUNCT
bionys-498	81	16	easy	easy	ADJ
bionys-498	81	17	®	®	NOUN
bionys-498	81	18	egfr	egfr	NOUN
bionys-498	81	19	”	"	PUNCT
bionys-498	81	20	kit	kit	NOUN
bionys-498	81	21	(	(	PUNCT
bionys-498	81	22	diatech	diatech	ADJ
bionys-498	81	23	pharmacogenetics	pharmacogenetic	NOUN
bionys-498	81	24	,	,	PUNCT
bionys-498	81	25	italy	italy	PROPN
bionys-498	81	26	)	)	PUNCT
bionys-498	81	27	with	with	ADP
bionys-498	81	28	a	a	DET
bionys-498	81	29	rotorgene	rotorgene	NOUN
bionys-498	81	30	6000	6000	NUM
bionys-498	81	31	-	-	PUNCT
bionys-498	81	32	corbett	corbett	NOUN
bionys-498	81	33	rt	rt	PROPN
bionys-498	81	34	-	-	PUNCT
bionys-498	81	35	pcr	pcr	ADJ
bionys-498	81	36	device	device	NOUN
bionys-498	81	37	(	(	PUNCT
bionys-498	81	38	diatech	diatech	ADJ
bionys-498	81	39	pharmacogenetics	pharmacogenetic	NOUN
bionys-498	81	40	,	,	PUNCT
bionys-498	81	41	italy	italy	PROPN
bionys-498	81	42	)	)	PUNCT
bionys-498	81	43	,	,	PUNCT
bionys-498	81	44	where	where	SCONJ
bionys-498	81	45	the	the	DET
bionys-498	81	46	list	list	NOUN
bionys-498	81	47	detectable	detectable	ADJ
bionys-498	81	48	mutations	mutation	NOUN
bionys-498	81	49	were	be	AUX
bionys-498	81	50	:	:	PUNCT
bionys-498	81	51	egfr	egfr	PROPN
bionys-498	81	52	exon	exon	NOUN
bionys-498	81	53	18	18	NUM
bionys-498	81	54	:	:	PUNCT
bionys-498	81	55	g719s	g719s	PROPN
bionys-498	81	56	(	(	PUNCT
bionys-498	81	57	2155g	2155g	NOUN
bionys-498	81	58	>	>	SYM
bionys-498	81	59	a	a	X
bionys-498	81	60	)	)	PUNCT
bionys-498	81	61	,	,	PUNCT
bionys-498	81	62	g719c	g719c	PROPN
bionys-498	81	63	(	(	PUNCT
bionys-498	81	64	2155g	2155g	NOUN
bionys-498	81	65	>	>	SYM
bionys-498	81	66	t	t	PROPN
bionys-498	81	67	)	)	PUNCT
bionys-498	81	68	,	,	PUNCT
bionys-498	81	69	g719a	g719a	PROPN
bionys-498	81	70	(	(	PUNCT
bionys-498	81	71	2156g	2156g	X
bionys-498	81	72	>	>	X
bionys-498	81	73	c	c	X
bionys-498	81	74	)	)	PUNCT
bionys-498	81	75	not	not	PART
bionys-498	81	76	distinguishable	distinguishable	ADJ
bionys-498	81	77	between	between	ADP
bionys-498	81	78	them	they	PRON
bionys-498	81	79	;	;	PUNCT
bionys-498	81	80	egfr	egfr	PROPN
bionys-498	81	81	exon	exon	PROPN
bionys-498	81	82	19	19	NUM
bionys-498	81	83	:	:	PUNCT
bionys-498	81	84	e746_a750del	e746_a750del	NOUN
bionys-498	81	85	(	(	PUNCT
bionys-498	81	86	2235_2249del15	2235_2249del15	NUM
bionys-498	81	87	)	)	PUNCT
bionys-498	81	88	,	,	PUNCT
bionys-498	81	89	e746_a750del	e746_a750del	NOUN
bionys-498	81	90	(	(	PUNCT
bionys-498	81	91	2236_2250del15	2236_2250del15	NUM
bionys-498	81	92	)	)	PUNCT
bionys-498	81	93	,	,	PUNCT
bionys-498	81	94	l747_p753	l747_p753	PROPN
bionys-498	81	95	>	>	X
bionys-498	81	96	s	s	X
bionys-498	81	97	(	(	PUNCT
bionys-498	81	98	2240_2257del18	2240_2257del18	NUM
bionys-498	81	99	)	)	PUNCT
bionys-498	81	100	,	,	PUNCT
bionys-498	81	101	l747_a750	l747_a750	NOUN
bionys-498	81	102	>	>	X
bionys-498	81	103	p	p	X
bionys-498	81	104	(	(	PUNCT
bionys-498	81	105	2239_2248ttaagagaag	2239_2248ttaagagaag	NOUN
bionys-498	81	106	>	>	X
bionys-498	81	107	c	c	NOUN
bionys-498	81	108	)	)	PUNCT
bionys-498	81	109	,	,	PUNCT
bionys-498	81	110	e746_s752	e746_s752	VERB
bionys-498	81	111	>	>	X
bionys-498	81	112	v	v	X
bionys-498	81	113	(	(	PUNCT
bionys-498	81	114	2237_2255	2237_2255	NUM
bionys-498	81	115	>	>	X
bionys-498	81	116	t	t	PROPN
bionys-498	81	117	)	)	PUNCT
bionys-498	81	118	,	,	PUNCT
bionys-498	81	119	l747_t751del	l747_t751del	PROPN
bionys-498	81	120	(	(	PUNCT
bionys-498	81	121	2240_2254del15	2240_2254del15	NUM
bionys-498	81	122	)	)	PUNCT
bionys-498	81	123	,	,	PUNCT
bionys-498	81	124	l747_s752del	l747_s752del	X
bionys-498	81	125	(	(	PUNCT
bionys-498	81	126	2239_2256del18	2239_2256del18	NUM
bionys-498	81	127	)	)	PUNCT
bionys-498	81	128	,	,	PUNCT
bionys-498	81	129	e746_t751	e746_t751	NOUN
bionys-498	81	130	>	>	X
bionys-498	81	131	a	a	DET
bionys-498	81	132	(	(	PUNCT
bionys-498	81	133	2237_2251del15	2237_2251del15	NUM
bionys-498	81	134	)	)	PUNCT
bionys-498	81	135	,	,	PUNCT
bionys-498	81	136	l747_t751del	l747_t751del	PROPN
bionys-498	81	137	(	(	PUNCT
bionys-498	81	138	2239_2253del15	2239_2253del15	NUM
bionys-498	81	139	)	)	PUNCT
bionys-498	81	140	,	,	PUNCT
bionys-498	81	141	l747_t751	l747_t751	NOUN
bionys-498	81	142	>	>	X
bionys-498	81	143	p	p	X
bionys-498	81	144	(	(	PUNCT
bionys-498	81	145	2239_2251	2239_2251	X
bionys-498	81	146	>	>	X
bionys-498	81	147	c	c	NOUN
bionys-498	81	148	)	)	PUNCT
bionys-498	81	149	,	,	PUNCT
bionys-498	81	150	l747_e749del	l747_e749del	PROPN
bionys-498	81	151	(	(	PUNCT
bionys-498	81	152	2239_2247del9	2239_2247del9	NOUN
bionys-498	81	153	)	)	PUNCT
bionys-498	81	154	,	,	PUNCT
bionys-498	81	155	e746_e749del	e746_e749del	PROPN
bionys-498	81	156	(	(	PUNCT
bionys-498	81	157	2235_2246del12	2235_2246del12	NUM
bionys-498	81	158	)	)	PUNCT
bionys-498	81	159	,	,	PUNCT
bionys-498	81	160	l747_p753	l747_p753	NOUN
bionys-498	81	161	>	>	X
bionys-498	81	162	q	q	X
bionys-498	81	163	(	(	PUNCT
bionys-498	81	164	2239_2258	2239_2258	NUM
bionys-498	81	165	>	>	SYM
bionys-498	81	166	ca	ca	PROPN
bionys-498	81	167	)	)	PUNCT
bionys-498	81	168	,	,	PUNCT
bionys-498	81	169	l747_t751	l747_t751	NOUN
bionys-498	81	170	>	>	SYM
bionys-498	81	171	s	s	X
bionys-498	81	172	(	(	PUNCT
bionys-498	81	173	2240_2251del12	2240_2251del12	NUM
bionys-498	81	174	)	)	PUNCT
bionys-498	81	175	,	,	PUNCT
bionys-498	81	176	e746_s752	e746_s752	VERB
bionys-498	81	177	>	>	X
bionys-498	81	178	a	a	DET
bionys-498	81	179	(	(	PUNCT
bionys-498	81	180	2237_2254del18	2237_2254del18	NUM
bionys-498	81	181	)	)	PUNCT
bionys-498	81	182	,	,	PUNCT
bionys-498	81	183	l747_a750	l747_a750	NOUN
bionys-498	81	184	>	>	X
bionys-498	81	185	p	p	X
bionys-498	81	186	(	(	PUNCT
bionys-498	81	187	2238_2248	2238_2248	X
bionys-498	81	188	>	>	X
bionys-498	81	189	gc	gc	PROPN
bionys-498	81	190	)	)	PUNCT
bionys-498	81	191	,	,	PUNCT
bionys-498	81	192	e746_s752	e746_s752	VERB
bionys-498	81	193	>	>	X
bionys-498	81	194	d	d	X
bionys-498	81	195	(	(	PUNCT
bionys-498	81	196	2238_2255del18	2238_2255del18	NUM
bionys-498	81	197	)	)	PUNCT
bionys-498	81	198	,	,	PUNCT
bionys-498	81	199	e746	e746	NUM
bionys-498	81	200	_	_	PUNCT
bionys-498	82	1	t751	t751	PROPN
bionys-498	82	2	>	>	X
bionys-498	82	3	i	i	PROPN
bionys-498	82	4	(	(	PUNCT
bionys-498	82	5	2235_2252	2235_2252	NOUN
bionys-498	82	6	>	>	X
bionys-498	82	7	aat	aat	PROPN
bionys-498	82	8	)	)	PUNCT
bionys-498	82	9	,	,	PUNCT
bionys-498	82	10	l747_t751	l747_t751	NOUN
bionys-498	82	11	>	>	SYM
bionys-498	82	12	q	q	PROPN
bionys-498	82	13	(	(	PUNCT
bionys-498	82	14	2238_2252	2238_2252	NUM
bionys-498	82	15	>	>	SYM
bionys-498	82	16	gca	gca	PROPN
bionys-498	82	17	)	)	PUNCT
bionys-498	82	18	,	,	PUNCT
bionys-498	82	19	e746_t751del	e746_t751del	X
bionys-498	82	20	(	(	PUNCT
bionys-498	82	21	2236_2253del18	2236_2253del18	NUM
bionys-498	82	22	)	)	PUNCT
bionys-498	82	23	not	not	PART
bionys-498	82	24	distinguishable	distinguishable	ADJ
bionys-498	82	25	between	between	ADP
bionys-498	82	26	them	they	PRON
bionys-498	82	27	.	.	PUNCT
bionys-498	83	1	egfr	egfr	PROPN
bionys-498	83	2	exon	exon	PROPN
bionys-498	83	3	20	20	NUM
bionys-498	83	4	:	:	PUNCT
bionys-498	84	1	v769_d770insasv	v769_d770insasv	NUM
bionys-498	84	2	(	(	PUNCT
bionys-498	84	3	2	2	NUM
bionys-498	84	4	3	3	NUM
bionys-498	84	5	0	0	NUM
bionys-498	84	6	7	7	NUM
bionys-498	84	7	_	_	NOUN
bionys-498	84	8	2	2	NUM
bionys-498	84	9	3	3	NUM
bionys-498	84	10	0	0	NUM
bionys-498	84	11	8	8	NUM
bionys-498	84	12	i	i	PRON
bionys-498	84	13	n	n	VERB
bionys-498	84	14	s	s	VERB
bionys-498	84	15	g	g	NOUN
bionys-498	84	16	c	c	PROPN
bionys-498	84	17	c	c	NOUN
bionys-498	84	18	a	a	DET
bionys-498	84	19	g	g	NOUN
bionys-498	84	20	c	c	PROPN
bionys-498	84	21	g	g	PROPN
bionys-498	84	22	t	t	PROPN
bionys-498	84	23	g	g	PROPN
bionys-498	84	24	)	)	PUNCT
bionys-498	84	25	,	,	PUNCT
bionys-498	84	26	d	d	NOUN
bionys-498	84	27	7	7	NUM
bionys-498	84	28	7	7	NUM
bionys-498	84	29	0	0	NUM
bionys-498	84	30	_	_	PRON
bionys-498	84	31	n771insg	n771insg	NOUN
bionys-498	84	32	(	(	PUNCT
bionys-498	84	33	2310_2311insggt	2310_2311insggt	NUM
bionys-498	84	34	)	)	PUNCT
bionys-498	84	35	,	,	PUNCT
bionys-498	84	36	h773_v774insh	h773_v774insh	PROPN
bionys-498	84	37	(	(	PUNCT
bionys-498	84	38	2319_2320inscac	2319_2320inscac	NOUN
bionys-498	84	39	)	)	PUNCT
bionys-498	84	40	not	not	PART
bionys-498	84	41	distinguishable	distinguishable	ADJ
bionys-498	84	42	between	between	ADP
bionys-498	84	43	them	they	PRON
bionys-498	84	44	,	,	PUNCT
bionys-498	84	45	t790	t790	NUM
bionys-498	84	46	m	m	PROPN
bionys-498	84	47	(	(	PUNCT
bionys-498	84	48	2369c	2369c	NUM
bionys-498	84	49	>	>	X
bionys-498	84	50	t	t	PROPN
bionys-498	84	51	)	)	PUNCT
bionys-498	84	52	,	,	PUNCT
bionys-498	84	53	s768i	s768i	PROPN
bionys-498	84	54	(	(	PUNCT
bionys-498	84	55	2303g	2303g	NUM
bionys-498	84	56	>	>	X
bionys-498	84	57	t	t	PROPN
bionys-498	84	58	)	)	PUNCT
bionys-498	84	59	;	;	PUNCT
bionys-498	84	60	egfr	egfr	PROPN
bionys-498	84	61	exon	exon	PROPN
bionys-498	84	62	21	21	NUM
bionys-498	84	63	:	:	PUNCT
bionys-498	84	64	l858r	l858r	NOUN
bionys-498	84	65	(	(	PUNCT
bionys-498	84	66	2573t	2573t	NUM
bionys-498	84	67	>	>	SYM
bionys-498	84	68	g	g	NOUN
bionys-498	84	69	)	)	PUNCT
bionys-498	84	70	,	,	PUNCT
bionys-498	84	71	l861q	l861q	PROPN
bionys-498	84	72	(	(	PUNCT
bionys-498	84	73	2582t	2582t	NUM
bionys-498	84	74	>	>	PUNCT
bionys-498	84	75	a	a	X
bionys-498	84	76	)	)	PUNCT
bionys-498	84	77	.	.	PUNCT
bionys-498	85	1	egfr	egfr	PROPN
bionys-498	85	2	sequence	sequence	NOUN
bionys-498	85	3	was	be	AUX
bionys-498	85	4	amplified	amplify	VERB
bionys-498	85	5	using	use	VERB
bionys-498	85	6	a	a	DET
bionys-498	85	7	mixture	mixture	NOUN
bionys-498	85	8	of	of	ADP
bionys-498	85	9	10	10	NUM
bionys-498	85	10	μl	μl	PRON
bionys-498	85	11	taq	taq	NOUN
bionys-498	85	12	premix	premix	NOUN
bionys-498	85	13	,	,	PUNCT
bionys-498	85	14	4	4	NUM
bionys-498	85	15	μl	μl	PRON
bionys-498	85	16	double	double	ADJ
bionys-498	85	17	distilled	distil	VERB
bionys-498	85	18	(	(	PUNCT
bionys-498	85	19	dd	dd	NOUN
bionys-498	85	20	)	)	PUNCT
bionys-498	85	21	water	water	NOUN
bionys-498	85	22	,	,	PUNCT
bionys-498	85	23	1	1	NUM
bionys-498	85	24	μl	μl	ADP
bionys-498	85	25	mutation	mutation	NOUN
bionys-498	85	26	primers	primer	NOUN
bionys-498	85	27	,	,	PUNCT
bionys-498	85	28	and	and	CCONJ
bionys-498	85	29	5	5	NUM
bionys-498	85	30	μl	μl	ADJ
bionys-498	85	31	dna	dna	PROPN
bionys-498	85	32	template	template	NOUN
bionys-498	85	33	.	.	PUNCT
bionys-498	86	1	each	each	DET
bionys-498	86	2	run	run	NOUN
bionys-498	86	3	included	include	VERB
bionys-498	86	4	at	at	ADP
bionys-498	86	5	least	least	ADV
bionys-498	86	6	one	one	NUM
bionys-498	86	7	amplification	amplification	NOUN
bionys-498	86	8	of	of	ADP
bionys-498	86	9	the	the	DET
bionys-498	86	10	negative	negative	ADJ
bionys-498	86	11	control	control	NOUN
bionys-498	86	12	(	(	PUNCT
bionys-498	86	13	dd	dd	NOUN
bionys-498	86	14	water	water	NOUN
bionys-498	86	15	)	)	PUNCT
bionys-498	86	16	and	and	CCONJ
bionys-498	86	17	one	one	NUM
bionys-498	86	18	amplification	amplification	NOUN
bionys-498	86	19	of	of	ADP
bionys-498	86	20	the	the	DET
bionys-498	86	21	positive	positive	ADJ
bionys-498	86	22	control	control	NOUN
bionys-498	86	23	(	(	PUNCT
bionys-498	86	24	„	„	PUNCT
bionys-498	86	25	easy	easy	ADJ
bionys-498	86	26	®	®	NOUN
bionys-498	86	27	egfr	egfr	NOUN
bionys-498	86	28	”	"	PUNCT
bionys-498	86	29	kit	kit	NOUN
bionys-498	86	30	positive	positive	ADJ
bionys-498	86	31	control	control	NOUN
bionys-498	86	32	)	)	PUNCT
bionys-498	86	33	.	.	PUNCT
bionys-498	87	1	egfr	egfr	PROPN
bionys-498	87	2	sequence	sequence	NOUN
bionys-498	87	3	was	be	AUX
bionys-498	87	4	amplified	amplify	VERB
bionys-498	87	5	using	use	VERB
bionys-498	87	6	the	the	DET
bionys-498	87	7	42	42	NUM
bionys-498	87	8	biologica	biologica	PROPN
bionys-498	87	9	nyssana	nyssana	PROPN
bionys-498	88	1	●	●	PUNCT
bionys-498	88	2	14	14	NUM
bionys-498	88	3	(	(	PUNCT
bionys-498	88	4	1	1	NUM
bionys-498	88	5	)	)	PUNCT
bionys-498	88	6	june	june	PROPN
bionys-498	88	7	2023	2023	NUM
bionys-498	88	8	:	:	PUNCT
bionys-498	88	9	39	39	NUM
bionys-498	88	10	-	-	SYM
bionys-498	88	11	46	46	NUM
bionys-498	88	12	were	be	AUX
bionys-498	88	13	patients	patient	NOUN
bionys-498	88	14	from	from	ADP
bionys-498	88	15	southern	southern	ADJ
bionys-498	88	16	and	and	CCONJ
bionys-498	88	17	eastern	eastern	ADJ
bionys-498	88	18	serbia	serbia	PROPN
bionys-498	88	19	,	,	PUNCT
bionys-498	88	20	with	with	ADP
bionys-498	88	21	640	640	NUM
bionys-498	88	22	males	male	NOUN
bionys-498	88	23	,	,	PUNCT
bionys-498	88	24	and	and	CCONJ
bionys-498	88	25	371	371	NUM
bionys-498	88	26	females	female	NOUN
bionys-498	88	27	.	.	PUNCT
bionys-498	89	1	at	at	ADP
bionys-498	89	2	the	the	DET
bionys-498	89	3	same	same	ADJ
bionys-498	89	4	time	time	NOUN
bionys-498	89	5	,	,	PUNCT
bionys-498	89	6	the	the	DET
bionys-498	89	7	total	total	ADJ
bionys-498	89	8	number	number	NOUN
bionys-498	89	9	of	of	ADP
bionys-498	89	10	deaths	death	NOUN
bionys-498	89	11	caused	cause	VERB
bionys-498	89	12	by	by	ADP
bionys-498	89	13	crc	crc	NOUN
bionys-498	89	14	was	be	AUX
bionys-498	89	15	479	479	NUM
bionys-498	89	16	,	,	PUNCT
bionys-498	89	17	with	with	ADP
bionys-498	89	18	397	397	NUM
bionys-498	89	19	male	male	ADJ
bionys-498	89	20	and	and	CCONJ
bionys-498	89	21	182	182	NUM
bionys-498	89	22	female	female	ADJ
bionys-498	89	23	patients	patient	NOUN
bionys-498	89	24	(	(	PUNCT
bionys-498	89	25	institute	institute	NOUN
bionys-498	89	26	of	of	ADP
bionys-498	89	27	public	public	ADJ
bionys-498	89	28	health	health	NOUN
bionys-498	89	29	„	„	PUNCT
bionys-498	89	30	dr	dr	PROPN
bionys-498	89	31	.	.	PROPN
bionys-498	89	32	milan	milan	PROPN
bionys-498	89	33	jovanovic	jovanovic	PROPN
bionys-498	89	34	batut	batut	PROPN
bionys-498	89	35	”	"	PUNCT
bionys-498	89	36	,	,	PUNCT
bionys-498	89	37	2020	2020	NUM
bionys-498	89	38	)	)	PUNCT
bionys-498	89	39	.	.	PUNCT
bionys-498	90	1	a	a	DET
bionys-498	90	2	key	key	ADJ
bionys-498	90	3	role	role	NOUN
bionys-498	90	4	in	in	ADP
bionys-498	90	5	colorectal	colorectal	ADJ
bionys-498	90	6	carcinogenesis	carcinogenesis	NOUN
bionys-498	90	7	has	have	VERB
bionys-498	90	8	the	the	DET
bionys-498	90	9	egfr	egfr	NOUN
bionys-498	90	10	signaling	signal	VERB
bionys-498	90	11	pathway	pathway	NOUN
bionys-498	90	12	,	,	PUNCT
bionys-498	90	13	which	which	PRON
bionys-498	90	14	is	be	AUX
bionys-498	90	15	involved	involve	VERB
bionys-498	90	16	in	in	ADP
bionys-498	90	17	the	the	DET
bionys-498	90	18	initiation	initiation	NOUN
bionys-498	90	19	of	of	ADP
bionys-498	90	20	human	human	ADJ
bionys-498	90	21	epithelial	epithelial	ADJ
bionys-498	90	22	cancers	cancer	NOUN
bionys-498	90	23	.	.	PUNCT
bionys-498	91	1	the	the	DET
bionys-498	91	2	most	most	ADV
bionys-498	91	3	common	common	ADJ
bionys-498	91	4	pathological	pathological	ADJ
bionys-498	91	5	changes	change	NOUN
bionys-498	91	6	of	of	ADP
bionys-498	91	7	egfr	egfr	NOUN
bionys-498	91	8	are	be	AUX
bionys-498	91	9	overexpression	overexpression	NOUN
bionys-498	91	10	of	of	ADP
bionys-498	91	11	egfr	egfr	ADJ
bionys-498	91	12	protein	protein	NOUN
bionys-498	91	13	and	and	CCONJ
bionys-498	91	14	egfr	egfr	ADJ
bionys-498	91	15	mutations	mutation	NOUN
bionys-498	91	16	that	that	PRON
bionys-498	91	17	activate	activate	VERB
bionys-498	91	18	the	the	DET
bionys-498	91	19	kinase	kinase	NOUN
bionys-498	91	20	.	.	PUNCT
bionys-498	92	1	based	base	VERB
bionys-498	92	2	on	on	ADP
bionys-498	92	3	the	the	DET
bionys-498	92	4	hypothesis	hypothesis	NOUN
bionys-498	92	5	that	that	PRON
bionys-498	92	6	a	a	DET
bionys-498	92	7	monoclonal	monoclonal	NOUN
bionys-498	92	8	antibody	antibody	NOUN
bionys-498	92	9	against	against	ADP
bionys-498	92	10	egfr	egfr	NOUN
bionys-498	92	11	can	can	AUX
bionys-498	92	12	inhibit	inhibit	VERB
bionys-498	92	13	receptor	receptor	NOUN
bionys-498	92	14	tyrosine	tyrosine	NOUN
bionys-498	92	15	kinase	kinase	PROPN
bionys-498	92	16	activity	activity	NOUN
bionys-498	92	17	and	and	CCONJ
bionys-498	92	18	cancer	cancer	NOUN
bionys-498	92	19	cell	cell	NOUN
bionys-498	92	20	proliferation	proliferation	NOUN
bionys-498	92	21	,	,	PUNCT
bionys-498	92	22	proposed	propose	VERB
bionys-498	92	23	in	in	ADP
bionys-498	92	24	1980	1980	NUM
bionys-498	92	25	by	by	ADP
bionys-498	92	26	dr	dr	PROPN
bionys-498	92	27	.	.	PROPN
bionys-498	92	28	john	john	PROPN
bionys-498	92	29	mendelsohn	mendelsohn	PROPN
bionys-498	92	30	and	and	CCONJ
bionys-498	92	31	gordon	gordon	PROPN
bionys-498	92	32	sato	sato	PROPN
bionys-498	92	33	,	,	PUNCT
bionys-498	92	34	years	year	NOUN
bionys-498	92	35	of	of	ADP
bionys-498	92	36	studies	study	NOUN
bionys-498	92	37	led	lead	VERB
bionys-498	92	38	to	to	ADP
bionys-498	92	39	the	the	DET
bionys-498	92	40	discovery	discovery	NOUN
bionys-498	92	41	of	of	ADP
bionys-498	92	42	anti	anti	ADJ
bionys-498	92	43	-	-	ADJ
bionys-498	92	44	egfr	egfr	ADJ
bionys-498	92	45	treatments	treatment	NOUN
bionys-498	92	46	for	for	ADP
bionys-498	92	47	specific	specific	ADJ
bionys-498	92	48	carcinomas	carcinoma	NOUN
bionys-498	92	49	such	such	ADJ
bionys-498	92	50	as	as	ADP
bionys-498	92	51	crc	crc	NOUN
bionys-498	92	52	and	and	CCONJ
bionys-498	92	53	non	non	ADJ
bionys-498	92	54	-	-	ADJ
bionys-498	92	55	small	small	ADJ
bionys-498	92	56	-	-	PUNCT
bionys-498	92	57	cell	cell	NOUN
bionys-498	92	58	lung	lung	NOUN
bionys-498	92	59	cancer	cancer	NOUN
bionys-498	92	60	(	(	PUNCT
bionys-498	92	61	nsclc	nsclc	NOUN
bionys-498	92	62	)	)	PUNCT
bionys-498	92	63	(	(	PUNCT
bionys-498	92	64	mendelsohn	mendelsohn	PROPN
bionys-498	92	65	et	et	PROPN
bionys-498	92	66	al	al	PROPN
bionys-498	92	67	.	.	PROPN
bionys-498	92	68	,	,	PUNCT
bionys-498	92	69	2015	2015	NUM
bionys-498	92	70	)	)	PUNCT
bionys-498	92	71	.	.	PUNCT
bionys-498	93	1	it	it	PRON
bionys-498	93	2	has	have	AUX
bionys-498	93	3	been	be	AUX
bionys-498	93	4	observed	observe	VERB
bionys-498	93	5	that	that	SCONJ
bionys-498	93	6	egfr	egfr	NOUN
bionys-498	93	7	-	-	PUNCT
bionys-498	93	8	directed	direct	VERB
bionys-498	93	9	therapy	therapy	NOUN
bionys-498	93	10	such	such	ADJ
bionys-498	93	11	as	as	ADP
bionys-498	93	12	cetuximab	cetuximab	NOUN
bionys-498	93	13	was	be	AUX
bionys-498	93	14	more	more	ADV
bionys-498	93	15	successful	successful	ADJ
bionys-498	93	16	in	in	ADP
bionys-498	93	17	crc	crc	NOUN
bionys-498	93	18	patients	patient	NOUN
bionys-498	93	19	with	with	ADP
bionys-498	93	20	highly	highly	ADV
bionys-498	93	21	expressed	express	VERB
bionys-498	93	22	egfr	egfr	NOUN
bionys-498	93	23	than	than	ADP
bionys-498	93	24	in	in	ADP
bionys-498	93	25	patients	patient	NOUN
bionys-498	93	26	with	with	ADP
bionys-498	93	27	low	low	ADJ
bionys-498	93	28	egfr	egfr	ADJ
bionys-498	93	29	expression	expression	NOUN
bionys-498	93	30	(	(	PUNCT
bionys-498	93	31	liu	liu	PROPN
bionys-498	93	32	et	et	PROPN
bionys-498	93	33	al	al	PROPN
bionys-498	93	34	.	.	PROPN
bionys-498	93	35	,	,	PUNCT
bionys-498	93	36	2016	2016	NUM
bionys-498	93	37	)	)	PUNCT
bionys-498	93	38	.	.	PUNCT
bionys-498	94	1	many	many	ADJ
bionys-498	94	2	studies	study	NOUN
bionys-498	94	3	evaluated	evaluate	VERB
bionys-498	94	4	the	the	DET
bionys-498	94	5	connection	connection	NOUN
bionys-498	94	6	between	between	ADP
bionys-498	94	7	over	over	ADV
bionys-498	94	8	-	-	PUNCT
bionys-498	94	9	expressed	express	VERB
bionys-498	94	10	egfr	egfr	NOUN
bionys-498	94	11	with	with	ADP
bionys-498	94	12	a	a	DET
bionys-498	94	13	variety	variety	NOUN
bionys-498	94	14	of	of	ADP
bionys-498	94	15	carcinomas	carcinoma	NOUN
bionys-498	94	16	such	such	ADJ
bionys-498	94	17	as	as	ADP
bionys-498	94	18	breast	breast	NOUN
bionys-498	94	19	cancer	cancer	NOUN
bionys-498	94	20	(	(	PUNCT
bionys-498	94	21	silva	silva	PROPN
bionys-498	94	22	rocha	rocha	PROPN
bionys-498	94	23	et	et	PROPN
bionys-498	94	24	al	al	PROPN
bionys-498	94	25	.	.	PROPN
bionys-498	94	26	,	,	PUNCT
bionys-498	94	27	2021	2021	NUM
bionys-498	94	28	)	)	PUNCT
bionys-498	94	29	,	,	PUNCT
bionys-498	94	30	table	table	NOUN
bionys-498	94	31	1	1	NUM
bionys-498	94	32	.	.	PUNCT
bionys-498	94	33	correlation	correlation	NOUN
bionys-498	94	34	between	between	ADP
bionys-498	94	35	egfr	egfr	ADJ
bionys-498	94	36	mutation	mutation	NOUN
bionys-498	94	37	status	status	NOUN
bionys-498	94	38	and	and	CCONJ
bionys-498	94	39	clinicopathological	clinicopathological	ADJ
bionys-498	94	40	parameters	parameter	NOUN
bionys-498	94	41	of	of	ADP
bionys-498	94	42	crc	crc	NOUN
bionys-498	94	43	patients	patient	NOUN
bionys-498	94	44	jugović	jugović	VERB
bionys-498	94	45	et	et	PROPN
bionys-498	94	46	al	al	PROPN
bionys-498	94	47	.	.	PUNCT
bionys-498	95	1	●	●	PUNCT
bionys-498	95	2	the	the	DET
bionys-498	95	3	frequency	frequency	NOUN
bionys-498	95	4	and	and	CCONJ
bionys-498	95	5	type	type	NOUN
bionys-498	95	6	of	of	ADP
bionys-498	95	7	mutations	mutation	NOUN
bionys-498	95	8	in	in	ADP
bionys-498	95	9	the	the	DET
bionys-498	95	10	egfr	egfr	ADJ
bionys-498	95	11	gene	gene	NOUN
bionys-498	95	12	of	of	ADP
bionys-498	95	13	colorectal	colorectal	ADJ
bionys-498	95	14	carcinoma	carcinoma	NOUN
bionys-498	95	15	patients	patient	NOUN
bionys-498	95	16	in	in	ADP
bionys-498	95	17	southeastern	southeastern	ADJ
bionys-498	95	18	serbia	serbia	PROPN
bionys-498	95	19	parameters	parameter	NOUN
bionys-498	95	20	n=38	n=38	ADV
bionys-498	95	21	egfr	egfr	X
bionys-498	95	22	status	status	NOUN
bionys-498	95	23	n=38	n=38	ADV
bionys-498	95	24	p	p	NOUN
bionys-498	95	25	value	value	NOUN
bionys-498	95	26	n	n	DET
bionys-498	95	27	%	%	NOUN
bionys-498	95	28	mutated	mutate	VERB
bionys-498	95	29	wt	wt	NOUN
bionys-498	95	30	sex	sex	NOUN
bionys-498	95	31	male	male	NOUN
bionys-498	95	32	24	24	NUM
bionys-498	95	33	63.2	63.2	NUM
bionys-498	95	34	2	2	NUM
bionys-498	95	35	22	22	NUM
bionys-498	95	36	0.89	0.89	NUM
bionys-498	95	37	female	female	NOUN
bionys-498	95	38	14	14	NUM
bionys-498	95	39	36.8	36.8	NUM
bionys-498	95	40	1	1	NUM
bionys-498	95	41	13	13	NUM
bionys-498	95	42	age	age	NOUN
bionys-498	95	43	at	at	ADP
bionys-498	95	44	diagnosis	diagnosis	NOUN
bionys-498	95	45	≤50	≤50	PROPN
bionys-498	95	46	6	6	NUM
bionys-498	95	47	15.8	15.8	NUM
bionys-498	95	48	/	/	SYM
bionys-498	95	49	6	6	NUM
bionys-498	95	50	51	51	NUM
bionys-498	95	51	-	-	SYM
bionys-498	95	52	60	60	NUM
bionys-498	95	53	6	6	NUM
bionys-498	95	54	15.8	15.8	NUM
bionys-498	95	55	/	/	SYM
bionys-498	95	56	6	6	NUM
bionys-498	95	57	61	61	NUM
bionys-498	95	58	-	-	SYM
bionys-498	95	59	70	70	NUM
bionys-498	95	60	18	18	NUM
bionys-498	95	61	47.4	47.4	NUM
bionys-498	95	62	2	2	NUM
bionys-498	95	63	16	16	NUM
bionys-498	95	64	≥71	≥71	NOUN
bionys-498	95	65	8	8	NUM
bionys-498	95	66	21.0	21.0	NUM
bionys-498	95	67	1	1	NUM
bionys-498	95	68	7	7	NUM
bionys-498	95	69	location	location	NOUN
bionys-498	95	70	left	leave	VERB
bionys-498	95	71	colon	colon	NOUN
bionys-498	95	72	23	23	NUM
bionys-498	95	73	60.5	60.5	NUM
bionys-498	95	74	2	2	NUM
bionys-498	95	75	21	21	NUM
bionys-498	95	76	0.82	0.82	NUM
bionys-498	95	77	right	right	ADJ
bionys-498	95	78	colon	colon	NOUN
bionys-498	95	79	15	15	NUM
bionys-498	95	80	39.5	39.5	NUM
bionys-498	95	81	1	1	NUM
bionys-498	95	82	14	14	NUM
bionys-498	95	83	tumor	tumor	NOUN
bionys-498	95	84	extent	extent	NOUN
bionys-498	95	85	t1	t1	PROPN
bionys-498	95	86	/	/	SYM
bionys-498	95	87	t2	t2	PROPN
bionys-498	95	88	14	14	NUM
bionys-498	95	89	36.8	36.8	NUM
bionys-498	95	90	2	2	NUM
bionys-498	95	91	12	12	NUM
bionys-498	95	92	0.26	0.26	NUM
bionys-498	95	93	t4	t4	PROPN
bionys-498	95	94	24	24	NUM
bionys-498	95	95	63.2	63.2	NUM
bionys-498	95	96	1	1	NUM
bionys-498	95	97	23	23	NUM
bionys-498	95	98	nodal	nodal	NOUN
bionys-498	95	99	status	status	NOUN
bionys-498	95	100	without	without	ADP
bionys-498	95	101	metastasis	metastasis	NOUN
bionys-498	95	102	14	14	NUM
bionys-498	95	103	36.8	36.8	NUM
bionys-498	95	104	2	2	NUM
bionys-498	95	105	12	12	NUM
bionys-498	95	106	0.26	0.26	NUM
bionys-498	95	107	with	with	ADP
bionys-498	95	108	metastasis	metastasis	NOUN
bionys-498	95	109	24	24	NUM
bionys-498	95	110	63.2	63.2	NUM
bionys-498	95	111	1	1	NUM
bionys-498	95	112	23	23	NUM
bionys-498	95	113	distant	distant	ADJ
bionys-498	95	114	metastasis	metastasis	NOUN
bionys-498	95	115	liver	liver	NOUN
bionys-498	95	116	19	19	NUM
bionys-498	95	117	50.0	50.0	NUM
bionys-498	95	118	/	/	SYM
bionys-498	95	119	19	19	NUM
bionys-498	95	120	lung	lung	NOUN
bionys-498	95	121	6	6	NUM
bionys-498	95	122	15.8	15.8	NUM
bionys-498	95	123	1	1	NUM
bionys-498	95	124	5	5	NUM
bionys-498	95	125	liver	liver	NOUN
bionys-498	95	126	and	and	CCONJ
bionys-498	95	127	lung	lung	NOUN
bionys-498	95	128	5	5	NUM
bionys-498	95	129	13.2	13.2	NUM
bionys-498	95	130	1	1	NUM
bionys-498	95	131	4	4	NUM
bionys-498	95	132	other	other	ADJ
bionys-498	95	133	8	8	NUM
bionys-498	95	134	21.0	21.0	NUM
bionys-498	95	135	1	1	NUM
bionys-498	95	136	7	7	NUM
bionys-498	95	137	wt	wt	NOUN
bionys-498	95	138	-	-	PUNCT
bionys-498	95	139	wild	wild	ADJ
bionys-498	95	140	type	type	NOUN
bionys-498	95	141	fig	fig	NOUN
bionys-498	95	142	.	.	PUNCT
bionys-498	96	1	1	1	X
bionys-498	96	2	.	.	X
bionys-498	96	3	g719x	g719x	NOUN
bionys-498	96	4	mutated	mutate	VERB
bionys-498	96	5	sample	sample	NOUN
bionys-498	96	6	and	and	CCONJ
bionys-498	96	7	amplification	amplification	NOUN
bionys-498	96	8	plot	plot	NOUN
bionys-498	96	9	detected	detect	VERB
bionys-498	96	10	by	by	ADP
bionys-498	96	11	„	„	PUNCT
bionys-498	96	12	easy	easy	ADJ
bionys-498	96	13	®	®	NOUN
bionys-498	96	14	egfr	egfr	NOUN
bionys-498	96	15	”	"	PUNCT
bionys-498	96	16	kit	kit	NOUN
bionys-498	96	17	biologica	biologica	PROPN
bionys-498	96	18	nyssana	nyssana	PROPN
bionys-498	96	19	●	●	PUNCT
bionys-498	96	20	14	14	NUM
bionys-498	96	21	(	(	PUNCT
bionys-498	96	22	1	1	NUM
bionys-498	96	23	)	)	PUNCT
bionys-498	96	24	june	june	PROPN
bionys-498	96	25	2023	2023	NUM
bionys-498	96	26	:	:	PUNCT
bionys-498	96	27	39	39	NUM
bionys-498	96	28	-	-	SYM
bionys-498	96	29	46	46	NUM
bionys-498	96	30	jugović	jugović	NOUN
bionys-498	96	31	et	et	PROPN
bionys-498	96	32	al	al	PROPN
bionys-498	96	33	.	.	PUNCT
bionys-498	97	1	●	●	PUNCT
bionys-498	97	2	the	the	DET
bionys-498	97	3	frequency	frequency	NOUN
bionys-498	97	4	and	and	CCONJ
bionys-498	97	5	type	type	NOUN
bionys-498	97	6	of	of	ADP
bionys-498	97	7	mutations	mutation	NOUN
bionys-498	97	8	in	in	ADP
bionys-498	97	9	the	the	DET
bionys-498	97	10	egfr	egfr	ADJ
bionys-498	97	11	gene	gene	NOUN
bionys-498	97	12	of	of	ADP
bionys-498	97	13	colorectal	colorectal	ADJ
bionys-498	97	14	carcinoma	carcinoma	NOUN
bionys-498	97	15	patients	patient	NOUN
bionys-498	97	16	in	in	ADP
bionys-498	97	17	southeastern	southeastern	ADJ
bionys-498	97	18	serbia	serbia	PROPN
bionys-498	97	19	stomach	stomach	NOUN
bionys-498	97	20	adenocarcinoma	adenocarcinoma	PROPN
bionys-498	97	21	(	(	PUNCT
bionys-498	97	22	wang	wang	PROPN
bionys-498	97	23	et	et	PROPN
bionys-498	97	24	al	al	PROPN
bionys-498	97	25	.	.	PROPN
bionys-498	97	26	,	,	PUNCT
bionys-498	97	27	2017	2017	NUM
bionys-498	97	28	)	)	PUNCT
bionys-498	97	29	,	,	PUNCT
bionys-498	97	30	prostate	prostate	NOUN
bionys-498	97	31	cancer	cancer	NOUN
bionys-498	97	32	(	(	PUNCT
bionys-498	97	33	hashmi	hashmi	PROPN
bionys-498	97	34	et	et	PROPN
bionys-498	97	35	al	al	PROPN
bionys-498	97	36	.	.	PROPN
bionys-498	97	37	,	,	PUNCT
bionys-498	97	38	2019	2019	NUM
bionys-498	97	39	)	)	PUNCT
bionys-498	97	40	,	,	PUNCT
bionys-498	97	41	nsclc	nsclc	NOUN
bionys-498	97	42	(	(	PUNCT
bionys-498	97	43	tasdemir	tasdemir	PROPN
bionys-498	97	44	et	et	PROPN
bionys-498	97	45	al	al	PROPN
bionys-498	97	46	.	.	PROPN
bionys-498	97	47	,	,	PUNCT
bionys-498	97	48	2019	2019	NUM
bionys-498	97	49	)	)	PUNCT
bionys-498	97	50	,	,	PUNCT
bionys-498	97	51	head	head	NOUN
bionys-498	97	52	and	and	CCONJ
bionys-498	97	53	neck	neck	NOUN
bionys-498	97	54	cancer	cancer	NOUN
bionys-498	97	55	(	(	PUNCT
bionys-498	97	56	barnes	barne	NOUN
bionys-498	97	57	et	et	PROPN
bionys-498	97	58	al	al	PROPN
bionys-498	97	59	.	.	PROPN
bionys-498	97	60	,	,	PUNCT
bionys-498	97	61	2020	2020	NUM
bionys-498	97	62	)	)	PUNCT
bionys-498	97	63	.	.	PUNCT
bionys-498	98	1	in	in	ADP
bionys-498	98	2	all	all	DET
bionys-498	98	3	these	these	DET
bionys-498	98	4	cancers	cancer	NOUN
bionys-498	98	5	,	,	PUNCT
bionys-498	98	6	the	the	DET
bionys-498	98	7	level	level	NOUN
bionys-498	98	8	of	of	ADP
bionys-498	98	9	expression	expression	NOUN
bionys-498	98	10	was	be	AUX
bionys-498	98	11	different	different	ADJ
bionys-498	98	12	with	with	ADP
bionys-498	98	13	a	a	DET
bionys-498	98	14	tendency	tendency	NOUN
bionys-498	98	15	to	to	PART
bionys-498	98	16	increase	increase	VERB
bionys-498	98	17	,	,	PUNCT
bionys-498	98	18	but	but	CCONJ
bionys-498	98	19	in	in	ADP
bionys-498	98	20	all	all	DET
bionys-498	98	21	cases	case	NOUN
bionys-498	98	22	,	,	PUNCT
bionys-498	98	23	egfr	egfr	ADJ
bionys-498	98	24	expression	expression	NOUN
bionys-498	98	25	was	be	AUX
bionys-498	98	26	recognized	recognize	VERB
bionys-498	98	27	as	as	ADP
bionys-498	98	28	an	an	DET
bionys-498	98	29	unfavorable	unfavorable	ADJ
bionys-498	98	30	prognostic	prognostic	ADJ
bionys-498	98	31	biomarker	biomarker	NOUN
bionys-498	98	32	of	of	ADP
bionys-498	98	33	the	the	DET
bionys-498	98	34	disease	disease	NOUN
bionys-498	98	35	.	.	PUNCT
bionys-498	99	1	furthermore	furthermore	ADV
bionys-498	99	2	,	,	PUNCT
bionys-498	99	3	many	many	ADJ
bionys-498	99	4	scientists	scientist	NOUN
bionys-498	99	5	have	have	AUX
bionys-498	99	6	been	be	AUX
bionys-498	99	7	researching	research	VERB
bionys-498	99	8	overexpression	overexpression	NOUN
bionys-498	99	9	and	and	CCONJ
bionys-498	99	10	abnormal	abnormal	ADJ
bionys-498	99	11	activation	activation	NOUN
bionys-498	99	12	of	of	ADP
bionys-498	99	13	the	the	DET
bionys-498	99	14	egfr	egfr	NOUN
bionys-498	99	15	in	in	ADP
bionys-498	99	16	crc	crc	NOUN
bionys-498	99	17	patients	patient	NOUN
bionys-498	99	18	.	.	PUNCT
bionys-498	100	1	these	these	DET
bionys-498	100	2	studies	study	NOUN
bionys-498	100	3	have	have	AUX
bionys-498	100	4	shown	show	VERB
bionys-498	100	5	the	the	DET
bionys-498	100	6	prognostic	prognostic	ADJ
bionys-498	100	7	value	value	NOUN
bionys-498	100	8	of	of	ADP
bionys-498	100	9	egfr	egfr	ADJ
bionys-498	100	10	expression	expression	NOUN
bionys-498	100	11	visible	visible	ADJ
bionys-498	100	12	as	as	ADP
bionys-498	100	13	the	the	DET
bionys-498	100	14	key	key	ADJ
bionys-498	100	15	factor	factor	NOUN
bionys-498	100	16	in	in	ADP
bionys-498	100	17	the	the	DET
bionys-498	100	18	invasion	invasion	NOUN
bionys-498	100	19	and	and	CCONJ
bionys-498	100	20	development	development	NOUN
bionys-498	100	21	of	of	ADP
bionys-498	100	22	metastasis	metastasis	NOUN
bionys-498	100	23	in	in	ADP
bionys-498	100	24	crc	crc	NOUN
bionys-498	100	25	patients	patient	NOUN
bionys-498	100	26	(	(	PUNCT
bionys-498	100	27	du	du	PROPN
bionys-498	100	28	et	et	PROPN
bionys-498	100	29	al	al	PROPN
bionys-498	100	30	.	.	PROPN
bionys-498	100	31	,	,	PUNCT
bionys-498	100	32	2017	2017	NUM
bionys-498	100	33	;	;	PUNCT
bionys-498	100	34	del	del	X
bionys-498	100	35	carmen	carmen	PROPN
bionys-498	100	36	et	et	PROPN
bionys-498	100	37	al	al	PROPN
bionys-498	100	38	.	.	PROPN
bionys-498	100	39	,	,	PUNCT
bionys-498	100	40	2020	2020	NUM
bionys-498	100	41	;	;	PUNCT
bionys-498	100	42	uhlyarik	uhlyarik	X
bionys-498	100	43	et	et	PROPN
bionys-498	100	44	al	al	PROPN
bionys-498	100	45	.	.	PROPN
bionys-498	100	46	,	,	PUNCT
bionys-498	100	47	2020	2020	NUM
bionys-498	100	48	)	)	PUNCT
bionys-498	100	49	.	.	PUNCT
bionys-498	101	1	in	in	ADP
bionys-498	101	2	addition	addition	NOUN
bionys-498	101	3	,	,	PUNCT
bionys-498	101	4	many	many	ADJ
bionys-498	101	5	studies	study	NOUN
bionys-498	101	6	evaluated	evaluate	VERB
bionys-498	101	7	the	the	DET
bionys-498	101	8	frequency	frequency	NOUN
bionys-498	101	9	of	of	ADP
bionys-498	101	10	mutations	mutation	NOUN
bionys-498	101	11	in	in	ADP
bionys-498	101	12	the	the	DET
bionys-498	101	13	egfr	egfr	ADJ
bionys-498	101	14	gene	gene	NOUN
bionys-498	101	15	in	in	ADP
bionys-498	101	16	a	a	DET
bionys-498	101	17	variety	variety	NOUN
bionys-498	101	18	of	of	ADP
bionys-498	101	19	cancers	cancer	NOUN
bionys-498	101	20	.	.	PUNCT
bionys-498	102	1	for	for	ADP
bionys-498	102	2	example	example	NOUN
bionys-498	102	3	,	,	PUNCT
bionys-498	102	4	it	it	PRON
bionys-498	102	5	has	have	AUX
bionys-498	102	6	been	be	AUX
bionys-498	102	7	observed	observe	VERB
bionys-498	102	8	that	that	SCONJ
bionys-498	102	9	in	in	ADP
bionys-498	102	10	nsclc	nsclc	NOUN
bionys-498	102	11	patients	patient	NOUN
bionys-498	102	12	mutations	mutation	NOUN
bionys-498	102	13	of	of	ADP
bionys-498	102	14	the	the	DET
bionys-498	102	15	gene	gene	NOUN
bionys-498	102	16	were	be	AUX
bionys-498	102	17	highly	highly	ADV
bionys-498	102	18	frequent	frequent	ADJ
bionys-498	102	19	in	in	ADP
bionys-498	102	20	exons	exon	NOUN
bionys-498	102	21	19	19	NUM
bionys-498	102	22	(	(	PUNCT
bionys-498	102	23	over	over	ADP
bionys-498	102	24	50	50	NUM
bionys-498	102	25	%	%	NOUN
bionys-498	102	26	)	)	PUNCT
bionys-498	102	27	and	and	CCONJ
bionys-498	102	28	less	less	ADV
bionys-498	102	29	frequent	frequent	ADJ
bionys-498	102	30	in	in	ADP
bionys-498	102	31	exons	exon	NOUN
bionys-498	102	32	18	18	NUM
bionys-498	102	33	and	and	CCONJ
bionys-498	102	34	20	20	NUM
bionys-498	102	35	(	(	PUNCT
bionys-498	102	36	8.1	8.1	NUM
bionys-498	102	37	%	%	NOUN
bionys-498	102	38	and	and	CCONJ
bionys-498	102	39	3.5	3.5	NUM
bionys-498	102	40	%	%	NOUN
bionys-498	102	41	)	)	PUNCT
bionys-498	102	42	(	(	PUNCT
bionys-498	102	43	skřičková	skřičková	NOUN
bionys-498	102	44	et	et	PROPN
bionys-498	102	45	al	al	PROPN
bionys-498	102	46	.	.	PROPN
bionys-498	102	47	,	,	PUNCT
bionys-498	102	48	2020	2020	NUM
bionys-498	102	49	)	)	PUNCT
bionys-498	102	50	.	.	PUNCT
bionys-498	103	1	interestingly	interestingly	ADV
bionys-498	103	2	,	,	PUNCT
bionys-498	103	3	nsclc	nsclc	NOUN
bionys-498	103	4	patients	patient	NOUN
bionys-498	103	5	with	with	ADP
bionys-498	103	6	a	a	DET
bionys-498	103	7	mutation	mutation	NOUN
bionys-498	103	8	in	in	ADP
bionys-498	103	9	exon	exon	PROPN
bionys-498	103	10	19	19	NUM
bionys-498	103	11	had	have	VERB
bionys-498	103	12	higher	high	ADJ
bionys-498	103	13	overall	overall	ADJ
bionys-498	103	14	survival	survival	NOUN
bionys-498	103	15	(	(	PUNCT
bionys-498	103	16	os	os	NOUN
bionys-498	103	17	)	)	PUNCT
bionys-498	103	18	rate	rate	NOUN
bionys-498	103	19	compared	compare	VERB
bionys-498	103	20	to	to	ADP
bionys-498	103	21	nsclc	nsclc	NOUN
bionys-498	103	22	patent	patent	NOUN
bionys-498	103	23	with	with	ADP
bionys-498	103	24	mutations	mutation	NOUN
bionys-498	103	25	in	in	ADP
bionys-498	103	26	exons	exon	NOUN
bionys-498	103	27	18	18	NUM
bionys-498	103	28	and	and	CCONJ
bionys-498	103	29	20	20	NUM
bionys-498	103	30	(	(	PUNCT
bionys-498	103	31	syrigos	syrigo	NOUN
bionys-498	103	32	et	et	PROPN
bionys-498	103	33	al	al	PROPN
bionys-498	103	34	.	.	PROPN
bionys-498	103	35	,	,	PUNCT
bionys-498	103	36	2018	2018	NUM
bionys-498	103	37	)	)	PUNCT
bionys-498	103	38	.	.	PUNCT
bionys-498	104	1	also	also	ADV
bionys-498	104	2	,	,	PUNCT
bionys-498	104	3	a	a	DET
bionys-498	104	4	high	high	ADJ
bionys-498	104	5	frequency	frequency	NOUN
bionys-498	104	6	of	of	ADP
bionys-498	104	7	mutations	mutation	NOUN
bionys-498	104	8	was	be	AUX
bionys-498	104	9	found	find	VERB
bionys-498	104	10	in	in	ADP
bionys-498	104	11	glioblastoma	glioblastoma	NOUN
bionys-498	104	12	multiforme	multiforme	NOUN
bionys-498	104	13	(	(	PUNCT
bionys-498	104	14	26.8	26.8	NUM
bionys-498	104	15	%	%	NOUN
bionys-498	104	16	)	)	PUNCT
bionys-498	104	17	,	,	PUNCT
bionys-498	104	18	lung	lung	NOUN
bionys-498	104	19	adenocarcinoma	adenocarcinoma	NOUN
bionys-498	104	20	(	(	PUNCT
bionys-498	104	21	14.4	14.4	NUM
bionys-498	104	22	%	%	NOUN
bionys-498	104	23	)	)	PUNCT
bionys-498	104	24	,	,	PUNCT
bionys-498	104	25	while	while	SCONJ
bionys-498	104	26	a	a	DET
bionys-498	104	27	low	low	ADJ
bionys-498	104	28	frequency	frequency	NOUN
bionys-498	104	29	of	of	ADP
bionys-498	104	30	mutations	mutation	NOUN
bionys-498	104	31	was	be	AUX
bionys-498	104	32	found	find	VERB
bionys-498	104	33	in	in	ADP
bionys-498	104	34	breast	breast	NOUN
bionys-498	104	35	invasive	invasive	ADJ
bionys-498	104	36	carcinoma	carcinoma	NOUN
bionys-498	104	37	,	,	PUNCT
bionys-498	104	38	kidney	kidney	NOUN
bionys-498	104	39	renal	renal	ADJ
bionys-498	104	40	papillary	papillary	NOUN
bionys-498	104	41	cell	cell	NOUN
bionys-498	104	42	carcinoma	carcinoma	NOUN
bionys-498	104	43	,	,	PUNCT
bionys-498	104	44	and	and	CCONJ
bionys-498	104	45	prostate	prostate	NOUN
bionys-498	104	46	adenocarcinoma	adenocarcinoma	NOUN
bionys-498	104	47	(	(	PUNCT
bionys-498	104	48	liu	liu	PROPN
bionys-498	104	49	et	et	PROPN
bionys-498	104	50	al	al	PROPN
bionys-498	104	51	.	.	PROPN
bionys-498	104	52	,	,	PUNCT
bionys-498	104	53	2020	2020	NUM
bionys-498	104	54	)	)	PUNCT
bionys-498	104	55	.	.	PUNCT
bionys-498	105	1	the	the	DET
bionys-498	105	2	results	result	NOUN
bionys-498	105	3	of	of	ADP
bionys-498	105	4	this	this	DET
bionys-498	105	5	study	study	NOUN
bionys-498	105	6	showed	show	VERB
bionys-498	105	7	that	that	SCONJ
bionys-498	105	8	of	of	ADP
bionys-498	105	9	38	38	NUM
bionys-498	105	10	patients	patient	NOUN
bionys-498	105	11	only	only	ADV
bionys-498	105	12	3	3	NUM
bionys-498	105	13	of	of	ADP
bionys-498	105	14	them	they	PRON
bionys-498	105	15	had	have	VERB
bionys-498	105	16	mutations	mutation	NOUN
bionys-498	105	17	in	in	ADP
bionys-498	105	18	the	the	DET
bionys-498	105	19	kinase	kinase	PROPN
bionys-498	105	20	domain	domain	NOUN
bionys-498	105	21	of	of	ADP
bionys-498	105	22	the	the	DET
bionys-498	105	23	egfr	egfr	NOUN
bionys-498	105	24	.	.	PUNCT
bionys-498	106	1	two	two	NUM
bionys-498	106	2	out	out	ADP
bionys-498	106	3	of	of	ADP
bionys-498	106	4	these	these	DET
bionys-498	106	5	three	three	NUM
bionys-498	106	6	patients	patient	NOUN
bionys-498	106	7	had	have	VERB
bionys-498	106	8	t2	t2	NOUN
bionys-498	106	9	stage	stage	NOUN
bionys-498	106	10	of	of	ADP
bionys-498	106	11	crc	crc	NOUN
bionys-498	106	12	,	,	PUNCT
bionys-498	106	13	located	locate	VERB
bionys-498	106	14	on	on	ADP
bionys-498	106	15	the	the	DET
bionys-498	106	16	left	left	ADJ
bionys-498	106	17	side	side	NOUN
bionys-498	106	18	of	of	ADP
bionys-498	106	19	the	the	DET
bionys-498	106	20	colon	colon	NOUN
bionys-498	106	21	and	and	CCONJ
bionys-498	106	22	the	the	DET
bionys-498	106	23	absence	absence	NOUN
bionys-498	106	24	of	of	ADP
bionys-498	106	25	metastasis	metastasis	NOUN
bionys-498	106	26	in	in	ADP
bionys-498	106	27	lymph	lymph	NOUN
bionys-498	106	28	nodes	node	NOUN
bionys-498	106	29	.	.	PUNCT
bionys-498	107	1	similarly	similarly	ADV
bionys-498	107	2	to	to	ADP
bionys-498	107	3	our	our	PRON
bionys-498	107	4	results	result	NOUN
bionys-498	107	5	,	,	PUNCT
bionys-498	107	6	the	the	DET
bionys-498	107	7	study	study	NOUN
bionys-498	107	8	of	of	ADP
bionys-498	107	9	oh	oh	INTJ
bionys-498	107	10	and	and	CCONJ
bionys-498	107	11	associates	associate	NOUN
bionys-498	107	12	showed	show	VERB
bionys-498	107	13	that	that	SCONJ
bionys-498	107	14	the	the	DET
bionys-498	107	15	presence	presence	NOUN
bionys-498	107	16	of	of	ADP
bionys-498	107	17	egfr	egfr	ADJ
bionys-498	107	18	mutations	mutation	NOUN
bionys-498	107	19	is	be	AUX
bionys-498	107	20	more	more	ADV
bionys-498	107	21	frequent	frequent	ADJ
bionys-498	107	22	in	in	ADP
bionys-498	107	23	the	the	DET
bionys-498	107	24	earlier	early	ADJ
bionys-498	107	25	stages	stage	NOUN
bionys-498	107	26	and	and	CCONJ
bionys-498	107	27	the	the	DET
bionys-498	107	28	absence	absence	NOUN
bionys-498	107	29	of	of	ADP
bionys-498	107	30	lymph	lymph	NOUN
bionys-498	107	31	node	node	NOUN
bionys-498	107	32	metastasis	metastasis	NOUN
bionys-498	107	33	(	(	PUNCT
bionys-498	107	34	oh	oh	INTJ
bionys-498	107	35	et	et	PROPN
bionys-498	107	36	al	al	PROPN
bionys-498	107	37	.	.	PROPN
bionys-498	107	38	,2011	,2011	PUNCT
bionys-498	107	39	)	)	PUNCT
bionys-498	107	40	.	.	PUNCT
bionys-498	108	1	moreover	moreover	ADV
bionys-498	108	2	,	,	PUNCT
bionys-498	108	3	our	our	PRON
bionys-498	108	4	results	result	NOUN
bionys-498	108	5	showed	show	VERB
bionys-498	108	6	that	that	SCONJ
bionys-498	108	7	all	all	DET
bionys-498	108	8	these	these	DET
bionys-498	108	9	three	three	NUM
bionys-498	108	10	patients	patient	NOUN
bionys-498	108	11	had	have	VERB
bionys-498	108	12	the	the	DET
bionys-498	108	13	same	same	ADJ
bionys-498	108	14	mutation	mutation	NOUN
bionys-498	108	15	,	,	PUNCT
bionys-498	108	16	i.e.	i.e.	X
bionys-498	108	17	,	,	PUNCT
bionys-498	108	18	in	in	ADP
bionys-498	108	19	exon	exon	NOUN
bionys-498	108	20	18	18	NUM
bionys-498	108	21	(	(	PUNCT
bionys-498	108	22	g719x	g719x	NOUN
bionys-498	108	23	)	)	PUNCT
bionys-498	108	24	.	.	PUNCT
bionys-498	109	1	ruhe	ruhe	PROPN
bionys-498	109	2	and	and	CCONJ
bionys-498	109	3	colleagues	colleague	NOUN
bionys-498	109	4	showed	show	VERB
bionys-498	109	5	that	that	SCONJ
bionys-498	109	6	one	one	NUM
bionys-498	109	7	of	of	ADP
bionys-498	109	8	the	the	DET
bionys-498	109	9	three	three	NUM
bionys-498	109	10	mutations	mutation	NOUN
bionys-498	109	11	in	in	ADP
bionys-498	109	12	exon	exon	NOUN
bionys-498	109	13	18	18	NUM
bionys-498	109	14	(	(	PUNCT
bionys-498	109	15	g719s	g719s	PROPN
bionys-498	109	16	)	)	PUNCT
bionys-498	109	17	identified	identify	VERB
bionys-498	109	18	in	in	ADP
bionys-498	109	19	the	the	DET
bionys-498	109	20	sw48	sw48	PROPN
bionys-498	109	21	colon	colon	NOUN
bionys-498	109	22	cancer	cancer	NOUN
bionys-498	109	23	cell	cell	NOUN
bionys-498	109	24	line	line	NOUN
bionys-498	109	25	had	have	VERB
bionys-498	109	26	oncogenic	oncogenic	ADJ
bionys-498	109	27	potential	potential	NOUN
bionys-498	109	28	(	(	PUNCT
bionys-498	109	29	ruhe	ruhe	PROPN
bionys-498	109	30	et	et	PROPN
bionys-498	109	31	al	al	PROPN
bionys-498	109	32	.	.	PROPN
bionys-498	109	33	,	,	PUNCT
bionys-498	109	34	2007	2007	NUM
bionys-498	109	35	)	)	PUNCT
bionys-498	109	36	.	.	PUNCT
bionys-498	110	1	at	at	ADP
bionys-498	110	2	the	the	DET
bionys-498	110	3	same	same	ADJ
bionys-498	110	4	time	time	NOUN
bionys-498	110	5	,	,	PUNCT
bionys-498	110	6	according	accord	VERB
bionys-498	110	7	to	to	ADP
bionys-498	110	8	kim	kim	PROPN
bionys-498	110	9	and	and	CCONJ
bionys-498	110	10	associates	associate	NOUN
bionys-498	110	11	,	,	PUNCT
bionys-498	110	12	inhibitors	inhibitor	NOUN
bionys-498	110	13	of	of	ADP
bionys-498	110	14	egfr	egfr	ADJ
bionys-498	110	15	tyrosine	tyrosine	NOUN
bionys-498	110	16	kinases	kinase	NOUN
bionys-498	110	17	,	,	PUNCT
bionys-498	110	18	such	such	ADJ
bionys-498	110	19	as	as	ADP
bionys-498	110	20	cetuximab	cetuximab	NOUN
bionys-498	110	21	and	and	CCONJ
bionys-498	110	22	panitumumab	panitumumab	NOUN
bionys-498	110	23	,	,	PUNCT
bionys-498	110	24	efficiently	efficiently	ADV
bionys-498	110	25	block	block	VERB
bionys-498	110	26	the	the	DET
bionys-498	110	27	growth	growth	NOUN
bionys-498	110	28	of	of	ADP
bionys-498	110	29	the	the	DET
bionys-498	110	30	same	same	ADJ
bionys-498	110	31	cell	cell	NOUN
bionys-498	110	32	line	line	NOUN
bionys-498	110	33	with	with	ADP
bionys-498	110	34	the	the	DET
bionys-498	110	35	same	same	ADJ
bionys-498	110	36	mutation	mutation	NOUN
bionys-498	110	37	(	(	PUNCT
bionys-498	110	38	kim	kim	PROPN
bionys-498	110	39	et	et	PROPN
bionys-498	110	40	al	al	PROPN
bionys-498	110	41	.	.	PROPN
bionys-498	110	42	2020	2020	NUM
bionys-498	110	43	,	,	PUNCT
bionys-498	110	44	cho	cho	PROPN
bionys-498	110	45	et	et	PROPN
bionys-498	110	46	al	al	PROPN
bionys-498	110	47	.	.	PROPN
bionys-498	110	48	,	,	PUNCT
bionys-498	110	49	2014	2014	NUM
bionys-498	110	50	)	)	PUNCT
bionys-498	110	51	.	.	PUNCT
bionys-498	111	1	having	have	VERB
bionys-498	111	2	in	in	ADP
bionys-498	111	3	mind	mind	NOUN
bionys-498	111	4	all	all	DET
bionys-498	111	5	these	these	PRON
bionys-498	111	6	,	,	PUNCT
bionys-498	111	7	it	it	PRON
bionys-498	111	8	might	might	AUX
bionys-498	111	9	be	be	AUX
bionys-498	111	10	concluded	conclude	VERB
bionys-498	111	11	that	that	SCONJ
bionys-498	111	12	crc	crc	NOUN
bionys-498	111	13	carriers	carrier	NOUN
bionys-498	111	14	of	of	ADP
bionys-498	111	15	egfr	egfr	ADJ
bionys-498	111	16	mutation	mutation	NOUN
bionys-498	111	17	in	in	ADP
bionys-498	111	18	exon	exon	PROPN
bionys-498	111	19	18	18	NUM
bionys-498	111	20	might	might	AUX
bionys-498	111	21	benefit	benefit	VERB
bionys-498	111	22	from	from	ADP
bionys-498	111	23	cetuximab	cetuximab	NOUN
bionys-498	111	24	or	or	CCONJ
bionys-498	111	25	panitumumab	panitumumab	NOUN
bionys-498	111	26	applied	apply	VERB
bionys-498	111	27	as	as	ADP
bionys-498	111	28	first	first	ADJ
bionys-498	111	29	-	-	PUNCT
bionys-498	111	30	line	line	NOUN
bionys-498	111	31	therapy	therapy	NOUN
bionys-498	111	32	.	.	PUNCT
bionys-498	112	1	the	the	DET
bionys-498	112	2	incidence	incidence	NOUN
bionys-498	112	3	of	of	ADP
bionys-498	112	4	mutated	mutate	VERB
bionys-498	112	5	egfr	egfr	NOUN
bionys-498	112	6	in	in	ADP
bionys-498	112	7	crc	crc	NOUN
bionys-498	112	8	patients	patient	NOUN
bionys-498	112	9	included	include	VERB
bionys-498	112	10	in	in	ADP
bionys-498	112	11	our	our	PRON
bionys-498	112	12	study	study	NOUN
bionys-498	112	13	was	be	AUX
bionys-498	112	14	only	only	ADV
bionys-498	112	15	7.9	7.9	NUM
bionys-498	112	16	%	%	NOUN
bionys-498	112	17	,	,	PUNCT
bionys-498	112	18	while	while	SCONJ
bionys-498	112	19	its	its	PRON
bionys-498	112	20	frequency	frequency	NOUN
bionys-498	112	21	in	in	ADP
bionys-498	112	22	the	the	DET
bionys-498	112	23	korean	korean	ADJ
bionys-498	112	24	population	population	NOUN
bionys-498	112	25	was	be	AUX
bionys-498	112	26	even	even	ADV
bionys-498	112	27	22.41	22.41	NUM
bionys-498	112	28	%	%	NOUN
bionys-498	112	29	.	.	PUNCT
bionys-498	113	1	on	on	ADP
bionys-498	113	2	the	the	DET
bionys-498	113	3	contrary	contrary	NOUN
bionys-498	113	4	to	to	ADP
bionys-498	113	5	the	the	DET
bionys-498	113	6	population	population	NOUN
bionys-498	113	7	of	of	ADP
bionys-498	113	8	southeast	southeast	PROPN
bionys-498	113	9	serbia	serbia	PROPN
bionys-498	113	10	,	,	PUNCT
bionys-498	113	11	their	their	PRON
bionys-498	113	12	population	population	NOUN
bionys-498	113	13	had	have	VERB
bionys-498	113	14	mutations	mutation	NOUN
bionys-498	113	15	only	only	ADV
bionys-498	113	16	in	in	ADP
bionys-498	113	17	exon	exon	NOUN
bionys-498	113	18	20	20	NUM
bionys-498	113	19	(	(	PUNCT
bionys-498	113	20	oh	oh	INTJ
bionys-498	113	21	et	et	PROPN
bionys-498	113	22	al	al	PROPN
bionys-498	113	23	.	.	PROPN
bionys-498	113	24	,	,	PUNCT
bionys-498	113	25	2011	2011	NUM
bionys-498	113	26	)	)	PUNCT
bionys-498	113	27	.	.	PUNCT
bionys-498	114	1	additionally	additionally	ADV
bionys-498	114	2	,	,	PUNCT
bionys-498	114	3	the	the	DET
bionys-498	114	4	frequency	frequency	NOUN
bionys-498	114	5	of	of	ADP
bionys-498	114	6	mutations	mutation	NOUN
bionys-498	114	7	of	of	ADP
bionys-498	114	8	in	in	ADP
bionys-498	114	9	exon	exon	NOUN
bionys-498	114	10	18	18	NUM
bionys-498	114	11	(	(	PUNCT
bionys-498	114	12	codon	codon	NOUN
bionys-498	114	13	719	719	NUM
bionys-498	114	14	)	)	PUNCT
bionys-498	114	15	in	in	ADP
bionys-498	114	16	our	our	PRON
bionys-498	114	17	study	study	NOUN
bionys-498	114	18	was	be	AUX
bionys-498	114	19	higher	high	ADJ
bionys-498	114	20	than	than	ADP
bionys-498	114	21	the	the	DET
bionys-498	114	22	frequency	frequency	NOUN
bionys-498	114	23	of	of	ADP
bionys-498	114	24	mutations	mutation	NOUN
bionys-498	114	25	in	in	ADP
bionys-498	114	26	the	the	DET
bionys-498	114	27	same	same	ADJ
bionys-498	114	28	exon	exon	NOUN
bionys-498	114	29	in	in	ADP
bionys-498	114	30	the	the	DET
bionys-498	114	31	european	european	ADJ
bionys-498	114	32	population	population	NOUN
bionys-498	114	33	(	(	PUNCT
bionys-498	114	34	2.6	2.6	NUM
bionys-498	114	35	%	%	NOUN
bionys-498	114	36	,	,	PUNCT
bionys-498	114	37	codons	codon	NOUN
bionys-498	114	38	707	707	NUM
bionys-498	114	39	,	,	PUNCT
bionys-498	114	40	710	710	NUM
bionys-498	114	41	,	,	PUNCT
bionys-498	114	42	711	711	NUM
bionys-498	114	43	,	,	PUNCT
bionys-498	114	44	712	712	NUM
bionys-498	114	45	,	,	PUNCT
bionys-498	114	46	725	725	NUM
bionys-498	114	47	)	)	PUNCT
bionys-498	114	48	(	(	PUNCT
bionys-498	114	49	metzger	metzger	NOUN
bionys-498	114	50	et	et	PROPN
bionys-498	114	51	al	al	PROPN
bionys-498	114	52	.	.	PROPN
bionys-498	114	53	,	,	PUNCT
bionys-498	114	54	2011	2011	NUM
bionys-498	114	55	)	)	PUNCT
bionys-498	114	56	.	.	PUNCT
bionys-498	115	1	our	our	PRON
bionys-498	115	2	results	result	NOUN
bionys-498	115	3	are	be	AUX
bionys-498	115	4	different	different	ADJ
bionys-498	115	5	from	from	ADP
bionys-498	115	6	the	the	DET
bionys-498	115	7	study	study	NOUN
bionys-498	115	8	of	of	ADP
bionys-498	115	9	phua	phua	PROPN
bionys-498	115	10	and	and	CCONJ
bionys-498	115	11	associates	associate	NOUN
bionys-498	115	12	who	who	PRON
bionys-498	115	13	did	do	AUX
bionys-498	115	14	not	not	PART
bionys-498	115	15	detect	detect	VERB
bionys-498	115	16	any	any	DET
bionys-498	115	17	mutations	mutation	NOUN
bionys-498	115	18	of	of	ADP
bionys-498	115	19	egfr	egfr	NOUN
bionys-498	115	20	in	in	ADP
bionys-498	115	21	codons	codon	NOUN
bionys-498	115	22	18	18	NUM
bionys-498	115	23	,	,	PUNCT
bionys-498	115	24	19	19	NUM
bionys-498	115	25	,	,	PUNCT
bionys-498	115	26	and	and	CCONJ
bionys-498	115	27	21	21	NUM
bionys-498	115	28	in	in	ADP
bionys-498	115	29	a	a	DET
bionys-498	115	30	group	group	NOUN
bionys-498	115	31	of	of	ADP
bionys-498	115	32	45	45	NUM
bionys-498	115	33	patients	patient	NOUN
bionys-498	115	34	with	with	ADP
bionys-498	115	35	crc	crc	PROPN
bionys-498	115	36	(	(	PUNCT
bionys-498	115	37	phua	phua	PROPN
bionys-498	115	38	et	et	PROPN
bionys-498	115	39	al	al	PROPN
bionys-498	115	40	.	.	PROPN
bionys-498	115	41	2015	2015	NUM
bionys-498	115	42	)	)	PUNCT
bionys-498	115	43	.	.	PUNCT
bionys-498	116	1	similarly	similarly	ADV
bionys-498	116	2	,	,	PUNCT
bionys-498	116	3	the	the	DET
bionys-498	116	4	study	study	NOUN
bionys-498	116	5	that	that	PRON
bionys-498	116	6	included	include	VERB
bionys-498	116	7	31	31	NUM
bionys-498	116	8	caucasians	caucasian	NOUN
bionys-498	116	9	did	do	AUX
bionys-498	116	10	not	not	PART
bionys-498	116	11	detect	detect	VERB
bionys-498	116	12	any	any	DET
bionys-498	116	13	mutations	mutation	NOUN
bionys-498	116	14	in	in	ADP
bionys-498	116	15	exons	exon	NOUN
bionys-498	116	16	18	18	NUM
bionys-498	116	17	and	and	CCONJ
bionys-498	116	18	19	19	NUM
bionys-498	116	19	,	,	PUNCT
bionys-498	116	20	while	while	SCONJ
bionys-498	116	21	only	only	ADV
bionys-498	116	22	one	one	NUM
bionys-498	116	23	of	of	ADP
bionys-498	116	24	them	they	PRON
bionys-498	116	25	had	have	VERB
bionys-498	116	26	a	a	DET
bionys-498	116	27	missense	missense	VERB
bionys-498	116	28	heterozygous	heterozygous	ADJ
bionys-498	116	29	mutation	mutation	NOUN
bionys-498	116	30	in	in	ADP
bionys-498	116	31	exon	exon	PROPN
bionys-498	116	32	21	21	NUM
bionys-498	116	33	(	(	PUNCT
bionys-498	116	34	gly857arg	gly857arg	NOUN
bionys-498	116	35	)	)	PUNCT
bionys-498	116	36	(	(	PUNCT
bionys-498	116	37	moroni	moroni	PROPN
bionys-498	116	38	et	et	PROPN
bionys-498	116	39	al	al	PROPN
bionys-498	116	40	.	.	PROPN
bionys-498	116	41	,	,	PUNCT
bionys-498	116	42	2005	2005	NUM
bionys-498	116	43	)	)	PUNCT
bionys-498	116	44	.	.	PUNCT
bionys-498	117	1	on	on	ADP
bionys-498	117	2	the	the	DET
bionys-498	117	3	other	other	ADJ
bionys-498	117	4	hand	hand	NOUN
bionys-498	117	5	,	,	PUNCT
bionys-498	117	6	barber	barber	PROPN
bionys-498	117	7	and	and	CCONJ
bionys-498	117	8	colleagues	colleague	NOUN
bionys-498	117	9	found	find	VERB
bionys-498	117	10	only	only	ADV
bionys-498	117	11	one	one	NUM
bionys-498	117	12	carrier	carrier	NOUN
bionys-498	117	13	of	of	ADP
bionys-498	117	14	g719s	g719s	PROPN
bionys-498	117	15	out	out	ADP
bionys-498	117	16	of	of	ADP
bionys-498	117	17	293	293	NUM
bionys-498	117	18	examined	examine	VERB
bionys-498	117	19	crc	crc	NOUN
bionys-498	117	20	patients	patient	NOUN
bionys-498	117	21	(	(	PUNCT
bionys-498	117	22	0,34	0,34	NUM
bionys-498	117	23	%	%	NOUN
bionys-498	117	24	)	)	PUNCT
bionys-498	117	25	(	(	PUNCT
bionys-498	117	26	barber	barber	PROPN
bionys-498	117	27	et	et	PROPN
bionys-498	117	28	al	al	PROPN
bionys-498	117	29	.	.	PROPN
bionys-498	117	30	,	,	PUNCT
bionys-498	117	31	2004	2004	NUM
bionys-498	117	32	)	)	PUNCT
bionys-498	117	33	,	,	PUNCT
bionys-498	117	34	while	while	SCONJ
bionys-498	117	35	the	the	DET
bionys-498	117	36	study	study	NOUN
bionys-498	117	37	of	of	ADP
bionys-498	117	38	ogino	ogino	NOUN
bionys-498	117	39	and	and	CCONJ
bionys-498	117	40	associates	associate	NOUN
bionys-498	117	41	showed	show	VERB
bionys-498	117	42	that	that	SCONJ
bionys-498	117	43	the	the	DET
bionys-498	117	44	incidence	incidence	NOUN
bionys-498	117	45	of	of	ADP
bionys-498	117	46	this	this	DET
bionys-498	117	47	mutation	mutation	NOUN
bionys-498	117	48	was	be	AUX
bionys-498	117	49	3.33	3.33	NUM
bionys-498	117	50	%	%	NOUN
bionys-498	117	51	(	(	PUNCT
bionys-498	117	52	1/30	1/30	NUM
bionys-498	117	53	)	)	PUNCT
bionys-498	117	54	(	(	PUNCT
bionys-498	117	55	ogino	ogino	NOUN
bionys-498	117	56	et	et	PROPN
bionys-498	117	57	al	al	PROPN
bionys-498	117	58	.	.	PROPN
bionys-498	117	59	,	,	PUNCT
bionys-498	117	60	2005	2005	NUM
bionys-498	117	61	)	)	PUNCT
bionys-498	117	62	.	.	PUNCT
bionys-498	118	1	in	in	ADP
bionys-498	118	2	romanian	romanian	ADJ
bionys-498	118	3	population	population	NOUN
bionys-498	118	4	,	,	PUNCT
bionys-498	118	5	the	the	DET
bionys-498	118	6	frequency	frequency	NOUN
bionys-498	118	7	of	of	ADP
bionys-498	118	8	egfr	egfr	ADJ
bionys-498	118	9	mutation	mutation	NOUN
bionys-498	118	10	in	in	ADP
bionys-498	118	11	exon	exon	PROPN
bionys-498	118	12	19	19	NUM
bionys-498	118	13	was	be	AUX
bionys-498	118	14	5	5	NUM
bionys-498	118	15	%	%	NOUN
bionys-498	118	16	(	(	PUNCT
bionys-498	118	17	3/60	3/60	NUM
bionys-498	118	18	)	)	PUNCT
bionys-498	118	19	,	,	PUNCT
bionys-498	118	20	and	and	CCONJ
bionys-498	118	21	it	it	PRON
bionys-498	118	22	was	be	AUX
bionys-498	118	23	positively	positively	ADV
bionys-498	118	24	correlated	correlate	VERB
bionys-498	118	25	with	with	ADP
bionys-498	118	26	lymphovascular	lymphovascular	ADJ
bionys-498	118	27	invasion	invasion	NOUN
bionys-498	118	28	,	,	PUNCT
bionys-498	118	29	perineural	perineural	ADJ
bionys-498	118	30	invasion	invasion	NOUN
bionys-498	118	31	,	,	PUNCT
bionys-498	118	32	tumor	tumor	NOUN
bionys-498	118	33	budding	budding	NOUN
bionys-498	118	34	of	of	ADP
bionys-498	118	35	all	all	DET
bionys-498	118	36	grades	grade	NOUN
bionys-498	118	37	as	as	ADV
bionys-498	118	38	well	well	ADV
bionys-498	118	39	as	as	ADP
bionys-498	118	40	with	with	ADP
bionys-498	118	41	the	the	DET
bionys-498	118	42	invasion	invasion	NOUN
bionys-498	118	43	of	of	ADP
bionys-498	118	44	tissues	tissue	NOUN
bionys-498	118	45	in	in	ADP
bionys-498	118	46	the	the	DET
bionys-498	118	47	proximity	proximity	NOUN
bionys-498	118	48	of	of	ADP
bionys-498	118	49	the	the	DET
bionys-498	118	50	tumor	tumor	NOUN
bionys-498	118	51	(	(	PUNCT
bionys-498	118	52	liver	liver	NOUN
bionys-498	118	53	,	,	PUNCT
bionys-498	118	54	visceral	visceral	ADJ
bionys-498	118	55	,	,	PUNCT
bionys-498	118	56	parietal	parietal	ADJ
bionys-498	118	57	pleura	pleura	NOUN
bionys-498	118	58	,	,	PUNCT
bionys-498	118	59	etc	etc	X
bionys-498	118	60	.	.	X
bionys-498	118	61	)	)	PUNCT
bionys-498	119	1	(	(	PUNCT
bionys-498	119	2	ionescu	ionescu	PROPN
bionys-498	119	3	et	et	PROPN
bionys-498	119	4	al	al	PROPN
bionys-498	119	5	.	.	PROPN
bionys-498	119	6	,	,	PUNCT
bionys-498	119	7	2022	2022	NUM
bionys-498	119	8	)	)	PUNCT
bionys-498	119	9	.	.	PUNCT
bionys-498	120	1	in	in	ADP
bionys-498	120	2	our	our	PRON
bionys-498	120	3	study	study	NOUN
bionys-498	120	4	,	,	PUNCT
bionys-498	120	5	we	we	PRON
bionys-498	120	6	did	do	AUX
bionys-498	120	7	not	not	PART
bionys-498	120	8	identify	identify	VERB
bionys-498	120	9	any	any	DET
bionys-498	120	10	mutation	mutation	NOUN
bionys-498	120	11	in	in	ADP
bionys-498	120	12	exon	exon	PROPN
bionys-498	120	13	19	19	NUM
bionys-498	120	14	.	.	PUNCT
bionys-498	121	1	however	however	ADV
bionys-498	121	2	,	,	PUNCT
bionys-498	121	3	we	we	PRON
bionys-498	121	4	noticed	notice	VERB
bionys-498	121	5	a	a	DET
bionys-498	121	6	trend	trend	NOUN
bionys-498	121	7	of	of	ADP
bionys-498	121	8	egfr	egfr	ADJ
bionys-498	121	9	mutation	mutation	NOUN
bionys-498	121	10	appearance	appearance	NOUN
bionys-498	121	11	in	in	ADP
bionys-498	121	12	the	the	DET
bionys-498	121	13	left	left	ADJ
bionys-498	121	14	-	-	PUNCT
bionys-498	121	15	sided	sided	ADJ
bionys-498	121	16	crc	crc	NOUN
bionys-498	121	17	(	(	PUNCT
bionys-498	121	18	2/3	2/3	NUM
bionys-498	121	19	)	)	PUNCT
bionys-498	121	20	,	,	PUNCT
bionys-498	121	21	while	while	SCONJ
bionys-498	121	22	the	the	DET
bionys-498	121	23	study	study	NOUN
bionys-498	121	24	of	of	ADP
bionys-498	121	25	randon	randon	NOUN
bionys-498	121	26	and	and	CCONJ
bionys-498	121	27	associates	associate	NOUN
bionys-498	121	28	observed	observe	VERB
bionys-498	121	29	a	a	DET
bionys-498	121	30	statistically	statistically	ADV
bionys-498	121	31	important	important	ADJ
bionys-498	121	32	correlation	correlation	NOUN
bionys-498	121	33	between	between	ADP
bionys-498	121	34	the	the	DET
bionys-498	121	35	amplification	amplification	NOUN
bionys-498	121	36	of	of	ADP
bionys-498	121	37	egfr	egfr	NOUN
bionys-498	121	38	and	and	CCONJ
bionys-498	121	39	wt	wt	ADP
bionys-498	121	40	ras	ras	NOUN
bionys-498	121	41	/	/	SYM
bionys-498	121	42	braf	braf	NOUN
bionys-498	121	43	in	in	ADP
bionys-498	121	44	leftsided	leftside	VERB
bionys-498	121	45	crc	crc	NOUN
bionys-498	121	46	(	(	PUNCT
bionys-498	121	47	randon	randon	PROPN
bionys-498	121	48	et	et	PROPN
bionys-498	121	49	al	al	PROPN
bionys-498	121	50	.	.	PROPN
bionys-498	121	51	,	,	PUNCT
bionys-498	121	52	2021	2021	NUM
bionys-498	121	53	)	)	PUNCT
bionys-498	121	54	.	.	PUNCT
bionys-498	122	1	over	over	ADP
bionys-498	122	2	60	60	NUM
bionys-498	122	3	%	%	NOUN
bionys-498	122	4	of	of	ADP
bionys-498	122	5	crc	crc	NOUN
bionys-498	122	6	patients	patient	NOUN
bionys-498	122	7	develop	develop	VERB
bionys-498	122	8	metastases	metastasis	NOUN
bionys-498	122	9	in	in	ADP
bionys-498	122	10	the	the	DET
bionys-498	122	11	liver	liver	NOUN
bionys-498	122	12	,	,	PUNCT
bionys-498	122	13	while	while	SCONJ
bionys-498	122	14	the	the	DET
bionys-498	122	15	second	second	ADJ
bionys-498	122	16	most	most	ADV
bionys-498	122	17	common	common	ADJ
bionys-498	122	18	site	site	NOUN
bionys-498	122	19	of	of	ADP
bionys-498	122	20	metastasis	metastasis	NOUN
bionys-498	122	21	is	be	AUX
bionys-498	122	22	the	the	DET
bionys-498	122	23	lungs	lung	NOUN
bionys-498	122	24	(	(	PUNCT
bionys-498	122	25	uhlyarik	uhlyarik	INTJ
bionys-498	122	26	et	et	PROPN
bionys-498	122	27	al	al	PROPN
bionys-498	122	28	.	.	PROPN
bionys-498	122	29	,	,	PUNCT
bionys-498	122	30	2020	2020	NUM
bionys-498	122	31	)	)	PUNCT
bionys-498	122	32	.	.	PUNCT
bionys-498	123	1	the	the	DET
bionys-498	123	2	presence	presence	NOUN
bionys-498	123	3	of	of	ADP
bionys-498	123	4	distant	distant	ADJ
bionys-498	123	5	metastases	metastasis	NOUN
bionys-498	123	6	greatly	greatly	ADV
bionys-498	123	7	reduces	reduce	VERB
bionys-498	123	8	the	the	DET
bionys-498	123	9	five	five	NUM
bionys-498	123	10	-	-	PUNCT
bionys-498	123	11	year	year	NOUN
bionys-498	123	12	survival	survival	NOUN
bionys-498	123	13	rate	rate	NOUN
bionys-498	123	14	,	,	PUNCT
bionys-498	123	15	and	and	CCONJ
bionys-498	123	16	the	the	DET
bionys-498	123	17	development	development	NOUN
bionys-498	123	18	of	of	ADP
bionys-498	123	19	these	these	DET
bionys-498	123	20	metastases	metastasis	NOUN
bionys-498	123	21	is	be	AUX
bionys-498	123	22	associated	associate	VERB
bionys-498	123	23	with	with	ADP
bionys-498	123	24	the	the	DET
bionys-498	123	25	mutation	mutation	NOUN
bionys-498	123	26	of	of	ADP
bionys-498	123	27	many	many	ADJ
bionys-498	123	28	genes	gene	NOUN
bionys-498	123	29	(	(	PUNCT
bionys-498	123	30	tanaka	tanaka	PROPN
bionys-498	123	31	et	et	PROPN
bionys-498	123	32	al	al	PROPN
bionys-498	123	33	.	.	PROPN
bionys-498	123	34	,	,	PUNCT
bionys-498	123	35	2019	2019	NUM
bionys-498	123	36	,	,	PUNCT
bionys-498	123	37	hao	hao	PROPN
bionys-498	123	38	et	et	PROPN
bionys-498	123	39	al	al	PROPN
bionys-498	123	40	.	.	PROPN
bionys-498	123	41	,	,	PUNCT
bionys-498	123	42	2022	2022	NUM
bionys-498	123	43	)	)	PUNCT
bionys-498	123	44	.	.	PUNCT
bionys-498	124	1	according	accord	VERB
bionys-498	124	2	to	to	ADP
bionys-498	124	3	the	the	DET
bionys-498	124	4	results	result	NOUN
bionys-498	124	5	of	of	ADP
bionys-498	124	6	our	our	PRON
bionys-498	124	7	study	study	NOUN
bionys-498	124	8	,	,	PUNCT
bionys-498	124	9	the	the	DET
bionys-498	124	10	presence	presence	NOUN
bionys-498	124	11	of	of	ADP
bionys-498	124	12	egfr	egfr	ADJ
bionys-498	124	13	mutation	mutation	NOUN
bionys-498	124	14	was	be	AUX
bionys-498	124	15	detected	detect	VERB
bionys-498	124	16	in	in	ADP
bionys-498	124	17	patients	patient	NOUN
bionys-498	124	18	with	with	ADP
bionys-498	124	19	distant	distant	ADJ
bionys-498	124	20	metastases	metastasis	NOUN
bionys-498	124	21	in	in	ADP
bionys-498	124	22	both	both	DET
bionys-498	124	23	lungs	lung	NOUN
bionys-498	124	24	and	and	CCONJ
bionys-498	124	25	liver	liver	NOUN
bionys-498	124	26	,	,	PUNCT
bionys-498	124	27	metastasis	metastasis	NOUN
bionys-498	124	28	only	only	ADV
bionys-498	124	29	in	in	ADP
bionys-498	124	30	lungs	lung	NOUN
bionys-498	124	31	,	,	PUNCT
bionys-498	124	32	and	and	CCONJ
bionys-498	124	33	metastasis	metastasis	NOUN
bionys-498	124	34	in	in	ADP
bionys-498	124	35	pelvis	pelvi	NOUN
bionys-498	124	36	.	.	PUNCT
bionys-498	125	1	however	however	ADV
bionys-498	125	2	,	,	PUNCT
bionys-498	125	3	contrary	contrary	ADV
bionys-498	125	4	to	to	ADP
bionys-498	125	5	the	the	DET
bionys-498	125	6	study	study	NOUN
bionys-498	125	7	of	of	ADP
bionys-498	125	8	zou	zou	PROPN
bionys-498	125	9	and	and	CCONJ
bionys-498	125	10	associates	associate	NOUN
bionys-498	125	11	that	that	PRON
bionys-498	125	12	detected	detect	VERB
bionys-498	125	13	a	a	DET
bionys-498	125	14	g735c	g735c	PROPN
bionys-498	125	15	mutation	mutation	NOUN
bionys-498	125	16	of	of	ADP
bionys-498	125	17	egfr	egfr	NOUN
bionys-498	125	18	in	in	ADP
bionys-498	125	19	one	one	NUM
bionys-498	125	20	patient	patient	NOUN
bionys-498	125	21	with	with	ADP
bionys-498	125	22	liver	liver	NOUN
bionys-498	125	23	metastasis	metastasis	NOUN
bionys-498	125	24	,	,	PUNCT
bionys-498	125	25	we	we	PRON
bionys-498	125	26	found	find	VERB
bionys-498	125	27	no	no	DET
bionys-498	125	28	mutation	mutation	NOUN
bionys-498	125	29	in	in	ADP
bionys-498	125	30	patients	patient	NOUN
bionys-498	125	31	with	with	ADP
bionys-498	125	32	metastasis	metastasis	NOUN
bionys-498	125	33	in	in	ADP
bionys-498	125	34	the	the	DET
bionys-498	125	35	liver	liver	NOUN
bionys-498	125	36	only	only	ADV
bionys-498	125	37	(	(	PUNCT
bionys-498	125	38	zou	zou	PROPN
bionys-498	125	39	et	et	PROPN
bionys-498	125	40	al	al	PROPN
bionys-498	125	41	.	.	PROPN
bionys-498	125	42	,	,	PUNCT
bionys-498	125	43	2018	2018	NUM
bionys-498	125	44	)	)	PUNCT
bionys-498	125	45	.	.	PUNCT
bionys-498	126	1	to	to	ADP
bionys-498	126	2	the	the	DET
bionys-498	126	3	best	good	ADJ
bionys-498	126	4	of	of	ADP
bionys-498	126	5	our	our	PRON
bionys-498	126	6	knowledge	knowledge	NOUN
bionys-498	126	7	,	,	PUNCT
bionys-498	126	8	this	this	PRON
bionys-498	126	9	is	be	AUX
bionys-498	126	10	the	the	DET
bionys-498	126	11	first	first	ADJ
bionys-498	126	12	report	report	NOUN
bionys-498	126	13	on	on	ADP
bionys-498	126	14	the	the	DET
bionys-498	126	15	evaluation	evaluation	NOUN
bionys-498	126	16	of	of	ADP
bionys-498	126	17	frequency	frequency	NOUN
bionys-498	126	18	and	and	CCONJ
bionys-498	126	19	type	type	NOUN
bionys-498	126	20	of	of	ADP
bionys-498	126	21	mutations	mutation	NOUN
bionys-498	126	22	in	in	ADP
bionys-498	126	23	the	the	DET
bionys-498	126	24	gene	gene	NOUN
bionys-498	126	25	and	and	CCONJ
bionys-498	126	26	its	its	PRON
bionys-498	126	27	correlation	correlation	NOUN
bionys-498	126	28	with	with	ADP
bionys-498	126	29	clinicopathological	clinicopathological	ADJ
bionys-498	126	30	characteristics	characteristic	NOUN
bionys-498	126	31	of	of	ADP
bionys-498	126	32	patients	patient	NOUN
bionys-498	126	33	with	with	ADP
bionys-498	126	34	43	43	NUM
bionys-498	126	35	biologica	biologica	PROPN
bionys-498	126	36	nyssana	nyssana	PROPN
bionys-498	127	1	●	●	PUNCT
bionys-498	127	2	14	14	NUM
bionys-498	127	3	(	(	PUNCT
bionys-498	127	4	1	1	NUM
bionys-498	127	5	)	)	PUNCT
bionys-498	127	6	june	june	PROPN
bionys-498	127	7	2023	2023	NUM
bionys-498	127	8	:	:	PUNCT
bionys-498	127	9	39	39	NUM
bionys-498	127	10	-	-	SYM
bionys-498	127	11	46	46	NUM
bionys-498	127	12	jugović	jugović	NOUN
bionys-498	127	13	et	et	PROPN
bionys-498	127	14	al	al	PROPN
bionys-498	127	15	.	.	PUNCT
bionys-498	128	1	●	●	PUNCT
bionys-498	128	2	the	the	DET
bionys-498	128	3	frequency	frequency	NOUN
bionys-498	128	4	and	and	CCONJ
bionys-498	128	5	type	type	NOUN
bionys-498	128	6	of	of	ADP
bionys-498	128	7	mutations	mutation	NOUN
bionys-498	128	8	in	in	ADP
bionys-498	128	9	the	the	DET
bionys-498	128	10	egfr	egfr	ADJ
bionys-498	128	11	gene	gene	NOUN
bionys-498	128	12	of	of	ADP
bionys-498	128	13	colorectal	colorectal	ADJ
bionys-498	128	14	carcinoma	carcinoma	NOUN
bionys-498	128	15	patients	patient	NOUN
bionys-498	128	16	in	in	ADP
bionys-498	128	17	southeastern	southeastern	ADJ
bionys-498	128	18	serbia	serbia	PROPN
bionys-498	128	19	garcía	garcía	PROPN
bionys-498	128	20	,	,	PUNCT
bionys-498	128	21	j.	j.	PROPN
bionys-498	128	22	,	,	PUNCT
bionys-498	128	23	bengoechea	bengoechea	PROPN
bionys-498	128	24	,	,	PUNCT
bionys-498	128	25	o.	o.	PROPN
bionys-498	128	26	,	,	PUNCT
bionys-498	128	27	muñoz	muñoz	PROPN
bionys-498	128	28	-	-	PUNCT
bionys-498	128	29	bellvis	bellvis	PROPN
bionys-498	128	30	,	,	PUNCT
bionys-498	128	31	l.	l.	PROPN
bionys-498	128	32	,	,	PUNCT
bionys-498	128	33	sayagués	sayagués	PROPN
bionys-498	128	34	,	,	PUNCT
bionys-498	128	35	j.m	j.m	PROPN
bionys-498	128	36	.	.	PROPN
bionys-498	128	37	,	,	PUNCT
bionys-498	128	38	&	&	CCONJ
bionys-498	128	39	abad	abad	PROPN
bionys-498	128	40	,	,	PUNCT
bionys-498	128	41	m.	m.	NOUN
bionys-498	128	42	(	(	PUNCT
bionys-498	128	43	2020	2020	NUM
bionys-498	128	44	)	)	PUNCT
bionys-498	128	45	.	.	PUNCT
bionys-498	129	1	prognostic	prognostic	ADJ
bionys-498	129	2	implications	implication	NOUN
bionys-498	129	3	of	of	ADP
bionys-498	129	4	egfr	egfr	ADJ
bionys-498	129	5	protein	protein	NOUN
bionys-498	129	6	expression	expression	NOUN
bionys-498	129	7	in	in	ADP
bionys-498	129	8	sporadic	sporadic	ADJ
bionys-498	129	9	colorectal	colorectal	ADJ
bionys-498	129	10	tumors	tumor	NOUN
bionys-498	129	11	:	:	PUNCT
bionys-498	129	12	correlation	correlation	NOUN
bionys-498	129	13	with	with	ADP
bionys-498	129	14	copy	copy	NOUN
bionys-498	129	15	number	number	NOUN
bionys-498	129	16	status	status	NOUN
bionys-498	129	17	,	,	PUNCT
bionys-498	129	18	mrna	mrna	PROPN
bionys-498	129	19	levels	level	NOUN
bionys-498	129	20	and	and	CCONJ
bionys-498	129	21	mirna	mirna	PROPN
bionys-498	129	22	regulation	regulation	PROPN
bionys-498	129	23	.	.	PUNCT
bionys-498	130	1	scientific	scientific	ADJ
bionys-498	130	2	reports	report	NOUN
bionys-498	130	3	,	,	PUNCT
bionys-498	130	4	10	10	NUM
bionys-498	130	5	,	,	PUNCT
bionys-498	130	6	4662	4662	NUM
bionys-498	130	7	.	.	PUNCT
bionys-498	131	1	du	du	PROPN
bionys-498	131	2	,	,	PUNCT
bionys-498	131	3	p.	p.	PROPN
bionys-498	131	4	,	,	PUNCT
bionys-498	131	5	xu	xu	PROPN
bionys-498	131	6	,	,	PUNCT
bionys-498	131	7	b.	b.	PROPN
bionys-498	131	8	,	,	PUNCT
bionys-498	131	9	zhang	zhang	PROPN
bionys-498	131	10	,	,	PUNCT
bionys-498	131	11	d.	d.	PROPN
bionys-498	131	12	,	,	PUNCT
bionys-498	131	13	shao	shao	PROPN
bionys-498	131	14	,	,	PUNCT
bionys-498	131	15	y.	y.	PROPN
bionys-498	131	16	,	,	PUNCT
bionys-498	131	17	zheng	zheng	PROPN
bionys-498	131	18	,	,	PUNCT
bionys-498	131	19	x.	x.	PROPN
bionys-498	131	20	,	,	PUNCT
bionys-498	131	21	li	li	PROPN
bionys-498	131	22	,	,	PUNCT
bionys-498	131	23	x.	x.	PROPN
bionys-498	131	24	,	,	PUNCT
bionys-498	131	25	xiong	xiong	PROPN
bionys-498	131	26	,	,	PUNCT
bionys-498	131	27	y.	y.	PROPN
bionys-498	131	28	,	,	PUNCT
bionys-498	131	29	wu	wu	PROPN
bionys-498	131	30	,	,	PUNCT
bionys-498	131	31	c.	c.	PROPN
bionys-498	131	32	,	,	PUNCT
bionys-498	131	33	&	&	CCONJ
bionys-498	131	34	jiang	jiang	PROPN
bionys-498	131	35	,	,	PUNCT
bionys-498	131	36	j.	j.	PROPN
bionys-498	131	37	(	(	PUNCT
bionys-498	131	38	2017	2017	NUM
bionys-498	131	39	)	)	PUNCT
bionys-498	131	40	.	.	PUNCT
bionys-498	132	1	hierarchical	hierarchical	ADJ
bionys-498	132	2	investigating	investigate	VERB
bionys-498	132	3	the	the	DET
bionys-498	132	4	predictive	predictive	ADJ
bionys-498	132	5	value	value	NOUN
bionys-498	132	6	of	of	ADP
bionys-498	132	7	p53	p53	NOUN
bionys-498	132	8	,	,	PUNCT
bionys-498	132	9	cox2	cox2	NOUN
bionys-498	132	10	,	,	PUNCT
bionys-498	132	11	egfr	egfr	NOUN
bionys-498	132	12	,	,	PUNCT
bionys-498	132	13	nm23	nm23	PROPN
bionys-498	132	14	in	in	ADP
bionys-498	132	15	the	the	DET
bionys-498	132	16	post	post	ADJ
bionys-498	132	17	-	-	ADJ
bionys-498	132	18	operative	operative	ADJ
bionys-498	132	19	patients	patient	NOUN
bionys-498	132	20	with	with	ADP
bionys-498	132	21	colorectal	colorectal	ADJ
bionys-498	132	22	carcinoma	carcinoma	NOUN
bionys-498	132	23	.	.	PUNCT
bionys-498	133	1	oncotarget	oncotarget	NOUN
bionys-498	133	2	,	,	PUNCT
bionys-498	133	3	8(1	8(1	NOUN
bionys-498	133	4	)	)	PUNCT
bionys-498	133	5	,	,	PUNCT
bionys-498	133	6	954	954	NUM
bionys-498	133	7	–	–	PUNCT
bionys-498	133	8	966	966	NUM
bionys-498	133	9	.	.	X
bionys-498	133	10	ferlay	ferlay	PROPN
bionys-498	133	11	,	,	PUNCT
bionys-498	133	12	j.	j.	PROPN
bionys-498	133	13	,	,	PUNCT
bionys-498	133	14	ervik	ervik	NOUN
bionys-498	133	15	,	,	PUNCT
bionys-498	133	16	m.	m.	NOUN
bionys-498	133	17	,	,	PUNCT
bionys-498	133	18	lam	lam	PROPN
bionys-498	133	19	,	,	PUNCT
bionys-498	133	20	f.	f.	PROPN
bionys-498	133	21	,	,	PUNCT
bionys-498	133	22	colombet	colombet	PROPN
bionys-498	133	23	,	,	PUNCT
bionys-498	133	24	m.	m.	NOUN
bionys-498	133	25	,	,	PUNCT
bionys-498	133	26	mery	mery	PROPN
bionys-498	133	27	,	,	PUNCT
bionys-498	133	28	l.	l.	PROPN
bionys-498	133	29	,	,	PUNCT
bionys-498	133	30	piñeros	piñeros	PROPN
bionys-498	133	31	,	,	PUNCT
bionys-498	133	32	m.	m.	NOUN
bionys-498	133	33	,	,	PUNCT
bionys-498	133	34	znaor	znaor	NOUN
bionys-498	133	35	,	,	PUNCT
bionys-498	133	36	a.	a.	PROPN
bionys-498	133	37	,	,	PUNCT
bionys-498	133	38	soerjomataram	soerjomataram	PROPN
bionys-498	133	39	,	,	PUNCT
bionys-498	133	40	i.	i.	PROPN
bionys-498	133	41	,	,	PUNCT
bionys-498	133	42	&	&	CCONJ
bionys-498	133	43	bray	bray	PROPN
bionys-498	133	44	,	,	PUNCT
bionys-498	133	45	f.	f.	PROPN
bionys-498	133	46	(	(	PUNCT
bionys-498	133	47	2020	2020	NUM
bionys-498	133	48	)	)	PUNCT
bionys-498	133	49	.	.	PUNCT
bionys-498	134	1	global	global	ADJ
bionys-498	134	2	cancer	cancer	NOUN
bionys-498	134	3	observatory	observatory	NOUN
bionys-498	134	4	:	:	PUNCT
bionys-498	134	5	cancer	cancer	NOUN
bionys-498	134	6	today	today	NOUN
bionys-498	134	7	.	.	PUNCT
bionys-498	135	1	france	france	PROPN
bionys-498	135	2	,	,	PUNCT
bionys-498	135	3	lyon	lyon	PROPN
bionys-498	135	4	:	:	PUNCT
bionys-498	135	5	international	international	ADJ
bionys-498	135	6	agency	agency	NOUN
bionys-498	135	7	for	for	ADP
bionys-498	135	8	research	research	NOUN
bionys-498	135	9	on	on	ADP
bionys-498	135	10	cancer	cancer	NOUN
bionys-498	135	11	.	.	PUNCT
bionys-498	136	1	hao	hao	PROPN
bionys-498	136	2	,	,	PUNCT
bionys-498	136	3	m.	m.	PROPN
bionys-498	136	4	,	,	PUNCT
bionys-498	136	5	wang	wang	PROPN
bionys-498	136	6	,	,	PUNCT
bionys-498	136	7	k.	k.	PROPN
bionys-498	136	8	,	,	PUNCT
bionys-498	136	9	ding	ding	NOUN
bionys-498	136	10	,	,	PUNCT
bionys-498	136	11	y.	y.	PROPN
bionys-498	136	12	,	,	PUNCT
bionys-498	136	13	li	li	PROPN
bionys-498	136	14	,	,	PUNCT
bionys-498	136	15	h.	h.	PROPN
bionys-498	136	16	,	,	PUNCT
bionys-498	136	17	liu	liu	PROPN
bionys-498	136	18	,	,	PUNCT
bionys-498	136	19	y.	y.	PROPN
bionys-498	136	20	,	,	PUNCT
bionys-498	136	21	&	&	CCONJ
bionys-498	136	22	ding	ding	PROPN
bionys-498	136	23	,	,	PUNCT
bionys-498	136	24	l.	l.	PROPN
bionys-498	136	25	(	(	PUNCT
bionys-498	136	26	2022	2022	NUM
bionys-498	136	27	)	)	PUNCT
bionys-498	136	28	.	.	PUNCT
bionys-498	137	1	which	which	PRON
bionys-498	137	2	patients	patient	NOUN
bionys-498	137	3	are	be	AUX
bionys-498	137	4	prone	prone	ADJ
bionys-498	137	5	to	to	PART
bionys-498	137	6	suffer	suffer	VERB
bionys-498	137	7	liver	liver	NOUN
bionys-498	137	8	metastasis	metastasis	NOUN
bionys-498	137	9	?	?	PUNCT
bionys-498	138	1	a	a	DET
bionys-498	138	2	review	review	NOUN
bionys-498	138	3	of	of	ADP
bionys-498	138	4	risk	risk	NOUN
bionys-498	138	5	factors	factor	NOUN
bionys-498	138	6	of	of	ADP
bionys-498	138	7	metachronous	metachronous	ADJ
bionys-498	138	8	liver	liver	NOUN
bionys-498	138	9	metastasis	metastasis	NOUN
bionys-498	138	10	of	of	ADP
bionys-498	138	11	colorectal	colorectal	ADJ
bionys-498	138	12	cancer	cancer	NOUN
bionys-498	138	13	.	.	PUNCT
bionys-498	139	1	european	european	PROPN
bionys-498	139	2	journal	journal	PROPN
bionys-498	139	3	of	of	ADP
bionys-498	139	4	medical	medical	ADJ
bionys-498	139	5	research	research	NOUN
bionys-498	139	6	,	,	PUNCT
bionys-498	139	7	27(1	27(1	NUM
bionys-498	139	8	)	)	PUNCT
bionys-498	139	9	,	,	PUNCT
bionys-498	139	10	130	130	NUM
bionys-498	139	11	.	.	PUNCT
bionys-498	140	1	hashmi	hashmi	PROPN
bionys-498	140	2	,	,	PUNCT
bionys-498	140	3	a.a	a.a	PROPN
bionys-498	140	4	.	.	PROPN
bionys-498	140	5	,	,	PUNCT
bionys-498	140	6	hashmi	hashmi	PROPN
bionys-498	140	7	,	,	PUNCT
bionys-498	140	8	s.k	s.k	PROPN
bionys-498	140	9	.	.	PROPN
bionys-498	140	10	,	,	PUNCT
bionys-498	140	11	irfan	irfan	PROPN
bionys-498	140	12	,	,	PUNCT
bionys-498	140	13	m.	m.	NOUN
bionys-498	140	14	asif	asif	PROPN
bionys-498	140	15	,	,	PUNCT
bionys-498	140	16	h.	h.	PROPN
bionys-498	140	17	,	,	PUNCT
bionys-498	140	18	nisar	nisar	PROPN
bionys-498	140	19	,	,	PUNCT
bionys-498	140	20	l.	l.	PROPN
bionys-498	140	21	,	,	PUNCT
bionys-498	140	22	naeem	naeem	PROPN
bionys-498	140	23	,	,	PUNCT
bionys-498	140	24	m.	m.	NOUN
bionys-498	140	25	,	,	PUNCT
bionys-498	140	26	khan	khan	PROPN
bionys-498	140	27	,	,	PUNCT
bionys-498	140	28	e.y	e.y	PROPN
bionys-498	140	29	.	.	PROPN
bionys-498	140	30	,	,	PUNCT
bionys-498	140	31	baloch	baloch	PROPN
bionys-498	140	32	,	,	PUNCT
bionys-498	140	33	s.	s.	PROPN
bionys-498	140	34	,	,	PUNCT
bionys-498	140	35	&	&	CCONJ
bionys-498	140	36	farid	farid	PROPN
bionys-498	140	37	,	,	PUNCT
bionys-498	140	38	n.	n.	NOUN
bionys-498	140	39	(	(	PUNCT
bionys-498	140	40	2019	2019	NUM
bionys-498	140	41	)	)	PUNCT
bionys-498	140	42	.	.	PUNCT
bionys-498	141	1	prognostic	prognostic	ADJ
bionys-498	141	2	utility	utility	NOUN
bionys-498	141	3	of	of	ADP
bionys-498	141	4	epidermal	epidermal	ADJ
bionys-498	141	5	growth	growth	NOUN
bionys-498	141	6	factor	factor	NOUN
bionys-498	141	7	receptor	receptor	NOUN
bionys-498	141	8	(	(	PUNCT
bionys-498	141	9	egfr	egfr	ADJ
bionys-498	141	10	)	)	PUNCT
bionys-498	141	11	expression	expression	NOUN
bionys-498	141	12	in	in	ADP
bionys-498	141	13	prostatic	prostatic	ADJ
bionys-498	141	14	acinar	acinar	NOUN
bionys-498	141	15	adenocarcinoma	adenocarcinoma	NOUN
bionys-498	141	16	.	.	PUNCT
bionys-498	142	1	applied	apply	VERB
bionys-498	142	2	cancer	cancer	NOUN
bionys-498	142	3	research	research	NOUN
bionys-498	142	4	,	,	PUNCT
bionys-498	142	5	39	39	NUM
bionys-498	142	6	,	,	PUNCT
bionys-498	142	7	2	2	NUM
bionys-498	142	8	.	.	PUNCT
bionys-498	142	9	hirsh	hirsh	NOUN
bionys-498	142	10	,	,	PUNCT
bionys-498	142	11	v.	v.	PROPN
bionys-498	142	12	(	(	PUNCT
bionys-498	142	13	2018	2018	NUM
bionys-498	142	14	)	)	PUNCT
bionys-498	142	15	turning	turn	VERB
bionys-498	142	16	egfr	egfr	ADJ
bionys-498	142	17	mutation	mutation	NOUN
bionys-498	142	18	-	-	PUNCT
bionys-498	142	19	positive	positive	ADJ
bionys-498	142	20	non	non	ADJ
bionys-498	142	21	-	-	ADJ
bionys-498	142	22	small	small	ADJ
bionys-498	142	23	-	-	PUNCT
bionys-498	142	24	cell	cell	NOUN
bionys-498	142	25	lung	lung	NOUN
bionys-498	142	26	cancer	cancer	NOUN
bionys-498	142	27	into	into	ADP
bionys-498	142	28	a	a	DET
bionys-498	142	29	chronic	chronic	ADJ
bionys-498	142	30	disease	disease	NOUN
bionys-498	142	31	:	:	PUNCT
bionys-498	142	32	optimal	optimal	ADJ
bionys-498	142	33	sequential	sequential	ADJ
bionys-498	142	34	therapy	therapy	NOUN
bionys-498	142	35	with	with	ADP
bionys-498	142	36	egfr	egfr	ADJ
bionys-498	142	37	tyrosine	tyrosine	PROPN
bionys-498	142	38	kinase	kinase	PROPN
bionys-498	142	39	inhibitors	inhibitor	NOUN
bionys-498	142	40	.	.	PUNCT
bionys-498	143	1	therapeutic	therapeutic	ADJ
bionys-498	143	2	advances	advance	NOUN
bionys-498	143	3	in	in	ADP
bionys-498	143	4	medical	medical	ADJ
bionys-498	143	5	oncology	oncology	NOUN
bionys-498	143	6	,	,	PUNCT
bionys-498	143	7	10	10	NUM
bionys-498	143	8	,	,	PUNCT
bionys-498	143	9	1758834017753338	1758834017753338	NUM
bionys-498	143	10	.	.	PUNCT
bionys-498	144	1	institut	institut	PROPN
bionys-498	144	2	za	za	PROPN
bionys-498	144	3	javno	javno	PROPN
bionys-498	144	4	zdravlje	zdravlje	PROPN
bionys-498	144	5	srbije	srbije	PROPN
bionys-498	144	6	„	„	PUNCT
bionys-498	144	7	dr	dr	PROPN
bionys-498	144	8	milan	milan	PROPN
bionys-498	144	9	jovanović	jovanović	PROPN
bionys-498	144	10	batut	batut	PROPN
bionys-498	144	11	”	"	PUNCT
bionys-498	144	12	.	.	PUNCT
bionys-498	145	1	(	(	PUNCT
bionys-498	145	2	2018	2018	NUM
bionys-498	145	3	)	)	PUNCT
bionys-498	145	4	.	.	PUNCT
bionys-498	146	1	malignant	malignant	ADJ
bionys-498	146	2	tumours	tumours	PROPN
bionys-498	146	3	in	in	ADP
bionys-498	146	4	republic	republic	NOUN
bionys-498	146	5	of	of	ADP
bionys-498	146	6	serbia	serbia	PROPN
bionys-498	146	7	.	.	PUNCT
bionys-498	147	1	retrieved	retrieve	VERB
bionys-498	147	2	from	from	ADP
bionys-498	147	3	https://	https://	PROPN
bionys-498	147	4	w	w	PROPN
bionys-498	147	5	w	w	PROPN
bionys-498	147	6	w	w	PROPN
bionys-498	147	7	.	.	PUNCT
bionys-498	148	1	b	b	PROPN
bionys-498	148	2	a	a	DET
bionys-498	148	3	t	t	NOUN
bionys-498	148	4	u	u	NOUN
bionys-498	148	5	t	t	NOUN
bionys-498	148	6	.	.	PUNCT
bionys-498	149	1	o	o	NOUN
bionys-498	149	2	r	r	NOUN
bionys-498	149	3	g	g	NOUN
bionys-498	149	4	.	.	PUNCT
bionys-498	150	1	r	r	NOUN
bionys-498	150	2	s	s	NOUN
bionys-498	150	3	/	/	SYM
bionys-498	151	1	d	d	NOUN
bionys-498	151	2	o	o	X
bionys-498	151	3	w	w	NOUN
bionys-498	151	4	n	n	ADV
bionys-498	151	5	l	l	NOUN
bionys-498	151	6	o	o	NOUN
bionys-498	151	7	a	a	DET
bionys-498	151	8	d	d	X
bionys-498	151	9	/	/	SYM
bionys-498	151	10	p	p	X
bionys-498	151	11	u	u	PROPN
bionys-498	151	12	b	b	PROPN
bionys-498	151	13	l	l	NOUN
bionys-498	152	1	i	i	PRON
bionys-498	152	2	k	k	INTJ
bionys-498	153	1	a	a	X
bionys-498	153	2	c	c	NOUN
bionys-498	154	1	i	i	PRON
bionys-498	154	2	j	j	PROPN
bionys-498	154	3	e	e	PROPN
bionys-498	154	4	/	/	SYM
bionys-498	154	5	malignitumori2018.pdf	malignitumori2018.pdf	PROPN
bionys-498	154	6	ionescu	ionescu	PROPN
bionys-498	154	7	,	,	PUNCT
bionys-498	154	8	a.	a.	PROPN
bionys-498	154	9	,	,	PUNCT
bionys-498	154	10	bilteanu	bilteanu	PROPN
bionys-498	154	11	,	,	PUNCT
bionys-498	154	12	l.	l.	PROPN
bionys-498	154	13	,	,	PUNCT
bionys-498	154	14	geicu	geicu	NOUN
bionys-498	154	15	,	,	PUNCT
bionys-498	154	16	o.i	o.i	PROPN
bionys-498	154	17	.	.	PROPN
bionys-498	154	18	,	,	PUNCT
bionys-498	154	19	iordache	iordache	PROPN
bionys-498	154	20	,	,	PUNCT
bionys-498	154	21	f.	f.	PROPN
bionys-498	154	22	,	,	PUNCT
bionys-498	154	23	stanca	stanca	PROPN
bionys-498	154	24	,	,	PUNCT
bionys-498	154	25	l.	l.	PROPN
bionys-498	154	26	,	,	PUNCT
bionys-498	154	27	pisoschi	pisoschi	NOUN
bionys-498	154	28	,	,	PUNCT
bionys-498	154	29	a.m.	a.m.	ADV
bionys-498	154	30	,	,	PUNCT
bionys-498	154	31	miron	miron	PROPN
bionys-498	154	32	,	,	PUNCT
bionys-498	154	33	a.	a.	PROPN
bionys-498	154	34	,	,	PUNCT
bionys-498	154	35	serban	serban	PROPN
bionys-498	154	36	,	,	PUNCT
bionys-498	154	37	a.i	a.i	PROPN
bionys-498	154	38	.	.	PROPN
bionys-498	154	39	,	,	PUNCT
bionys-498	154	40	&	&	CCONJ
bionys-498	154	41	calu	calu	PROPN
bionys-498	154	42	,	,	PUNCT
bionys-498	154	43	v.	v.	PROPN
bionys-498	154	44	(	(	PUNCT
bionys-498	154	45	2022	2022	NUM
bionys-498	154	46	)	)	PUNCT
bionys-498	154	47	.	.	PUNCT
bionys-498	155	1	multivariate	multivariate	NOUN
bionys-498	155	2	risk	risk	NOUN
bionys-498	155	3	analysis	analysis	NOUN
bionys-498	155	4	of	of	ADP
bionys-498	155	5	ras	ras	NOUN
bionys-498	155	6	,	,	PUNCT
bionys-498	155	7	braf	braf	NOUN
bionys-498	155	8	and	and	CCONJ
bionys-498	155	9	egfr	egfr	ADJ
bionys-498	155	10	mutations	mutation	NOUN
bionys-498	155	11	allelic	allelic	ADJ
bionys-498	155	12	frequency	frequency	NOUN
bionys-498	155	13	and	and	CCONJ
bionys-498	155	14	coexistence	coexistence	NOUN
bionys-498	155	15	as	as	ADP
bionys-498	155	16	colorectal	colorectal	ADJ
bionys-498	155	17	cancer	cancer	NOUN
bionys-498	155	18	predictive	predictive	ADJ
bionys-498	155	19	biomarkers	biomarker	NOUN
bionys-498	155	20	.	.	PUNCT
bionys-498	156	1	cancers	cancer	NOUN
bionys-498	156	2	,	,	PUNCT
bionys-498	156	3	14(11	14(11	NUM
bionys-498	156	4	)	)	PUNCT
bionys-498	156	5	,	,	PUNCT
bionys-498	156	6	2792	2792	NUM
bionys-498	156	7	.	.	PUNCT
bionys-498	157	1	kim	kim	PROPN
bionys-498	157	2	,	,	PUNCT
bionys-498	157	3	n.	n.	PROPN
bionys-498	157	4	,	,	PUNCT
bionys-498	157	5	cho	cho	PROPN
bionys-498	157	6	,	,	PUNCT
bionys-498	157	7	d.	d.	PROPN
bionys-498	157	8	,	,	PUNCT
bionys-498	157	9	kim	kim	PROPN
bionys-498	157	10	,	,	PUNCT
bionys-498	157	11	h.	h.	PROPN
bionys-498	157	12	,	,	PUNCT
bionys-498	157	13	kim	kim	PROPN
bionys-498	157	14	,	,	PUNCT
bionys-498	157	15	s.	s.	PROPN
bionys-498	157	16	,	,	PUNCT
bionys-498	157	17	cha	cha	PROPN
bionys-498	157	18	,	,	PUNCT
bionys-498	157	19	y.j	y.j	PROPN
bionys-498	157	20	.	.	PROPN
bionys-498	157	21	,	,	PUNCT
bionys-498	157	22	greulich	greulich	PROPN
bionys-498	157	23	,	,	PUNCT
bionys-498	157	24	h.	h.	PROPN
bionys-498	157	25	,	,	PUNCT
bionys-498	157	26	bass	bass	PROPN
bionys-498	157	27	,	,	PUNCT
bionys-498	157	28	a.	a.	NOUN
bionys-498	157	29	,	,	PUNCT
bionys-498	157	30	cho	cho	PROPN
bionys-498	157	31	,	,	PUNCT
bionys-498	157	32	h.s	h.s	PROPN
bionys-498	157	33	.	.	PROPN
bionys-498	157	34	,	,	PUNCT
bionys-498	157	35	&	&	CCONJ
bionys-498	157	36	cho	cho	PROPN
bionys-498	157	37	,	,	PUNCT
bionys-498	157	38	j.	j.	PROPN
bionys-498	157	39	(	(	PUNCT
bionys-498	157	40	2020	2020	NUM
bionys-498	157	41	)	)	PUNCT
bionys-498	157	42	.	.	PUNCT
bionys-498	158	1	colorectal	colorectal	ADJ
bionys-498	158	2	adenocarcinoma	adenocarcinoma	NOUN
bionys-498	158	3	-	-	PUNCT
bionys-498	158	4	derived	derive	VERB
bionys-498	158	5	egfr	egfr	ADJ
bionys-498	158	6	mutants	mutant	NOUN
bionys-498	158	7	are	be	AUX
bionys-498	158	8	oncogenic	oncogenic	ADJ
bionys-498	158	9	and	and	CCONJ
bionys-498	158	10	sensitive	sensitive	ADJ
bionys-498	158	11	to	to	ADP
bionys-498	158	12	egfr	egfr	ADJ
bionys-498	158	13	-	-	PUNCT
bionys-498	158	14	targeted	target	VERB
bionys-498	158	15	monoclonal	monoclonal	NOUN
bionys-498	158	16	antibodies	antibody	NOUN
bionys-498	158	17	,	,	PUNCT
bionys-498	158	18	cetuximab	cetuximab	NOUN
bionys-498	158	19	and	and	CCONJ
bionys-498	158	20	panitumumab	panitumumab	NOUN
bionys-498	158	21	.	.	PUNCT
bionys-498	159	1	international	international	ADJ
bionys-498	159	2	journal	journal	PROPN
bionys-498	159	3	of	of	ADP
bionys-498	159	4	cancer	cancer	NOUN
bionys-498	159	5	,	,	PUNCT
bionys-498	159	6	146(8	146(8	NUM
bionys-498	159	7	)	)	PUNCT
bionys-498	159	8	,	,	PUNCT
bionys-498	159	9	2194–2200	2194–2200	NUM
bionys-498	159	10	.	.	PUNCT
bionys-498	160	1	crc	crc	NOUN
bionys-498	160	2	on	on	ADP
bionys-498	160	3	the	the	DET
bionys-498	160	4	territory	territory	NOUN
bionys-498	160	5	of	of	ADP
bionys-498	160	6	southeastern	southeastern	ADJ
bionys-498	160	7	serbia	serbia	PROPN
bionys-498	160	8	.	.	PUNCT
bionys-498	161	1	conclusion	conclusion	VERB
bionys-498	161	2	the	the	DET
bionys-498	161	3	incidence	incidence	NOUN
bionys-498	161	4	of	of	ADP
bionys-498	161	5	mutations	mutation	NOUN
bionys-498	161	6	in	in	ADP
bionys-498	161	7	the	the	DET
bionys-498	161	8	egfr	egfr	NOUN
bionys-498	161	9	in	in	ADP
bionys-498	161	10	38	38	NUM
bionys-498	161	11	crc	crc	NOUN
bionys-498	161	12	patients	patient	NOUN
bionys-498	161	13	of	of	ADP
bionys-498	161	14	the	the	DET
bionys-498	161	15	southeastern	southeastern	ADJ
bionys-498	161	16	serbia	serbia	PROPN
bionys-498	161	17	was	be	AUX
bionys-498	161	18	relatively	relatively	ADV
bionys-498	161	19	low	low	ADJ
bionys-498	161	20	,	,	PUNCT
bionys-498	161	21	and	and	CCONJ
bionys-498	161	22	there	there	PRON
bionys-498	161	23	was	be	VERB
bionys-498	161	24	no	no	DET
bionys-498	161	25	significant	significant	ADJ
bionys-498	161	26	correlation	correlation	NOUN
bionys-498	161	27	between	between	ADP
bionys-498	161	28	egfr	egfr	ADJ
bionys-498	161	29	mutational	mutational	ADJ
bionys-498	161	30	status	status	NOUN
bionys-498	161	31	with	with	ADP
bionys-498	161	32	clinicopathological	clinicopathological	ADJ
bionys-498	161	33	characteristics	characteristic	NOUN
bionys-498	161	34	.	.	PUNCT
bionys-498	162	1	all	all	DET
bionys-498	162	2	detected	detect	VERB
bionys-498	162	3	mutations	mutation	NOUN
bionys-498	162	4	were	be	AUX
bionys-498	162	5	g719x	g719x	VERB
bionys-498	162	6	.	.	PUNCT
bionys-498	163	1	however	however	ADV
bionys-498	163	2	,	,	PUNCT
bionys-498	163	3	we	we	PRON
bionys-498	163	4	did	do	AUX
bionys-498	163	5	observe	observe	VERB
bionys-498	163	6	a	a	DET
bionys-498	163	7	trend	trend	NOUN
bionys-498	163	8	of	of	ADP
bionys-498	163	9	mutations	mutation	NOUN
bionys-498	163	10	appearing	appear	VERB
bionys-498	163	11	in	in	ADP
bionys-498	163	12	the	the	DET
bionys-498	163	13	lower	low	ADJ
bionys-498	163	14	stages	stage	NOUN
bionys-498	163	15	of	of	ADP
bionys-498	163	16	tumor	tumor	NOUN
bionys-498	163	17	infiltration	infiltration	NOUN
bionys-498	163	18	,	,	PUNCT
bionys-498	163	19	especially	especially	ADV
bionys-498	163	20	on	on	ADP
bionys-498	163	21	the	the	DET
bionys-498	163	22	left	left	ADJ
bionys-498	163	23	side	side	NOUN
bionys-498	163	24	of	of	ADP
bionys-498	163	25	the	the	DET
bionys-498	163	26	colon	colon	NOUN
bionys-498	163	27	without	without	ADP
bionys-498	163	28	the	the	DET
bionys-498	163	29	presence	presence	NOUN
bionys-498	163	30	of	of	ADP
bionys-498	163	31	metastases	metastasis	NOUN
bionys-498	163	32	in	in	ADP
bionys-498	163	33	the	the	DET
bionys-498	163	34	lymph	lymph	NOUN
bionys-498	163	35	nodes	node	NOUN
bionys-498	163	36	.	.	PUNCT
bionys-498	164	1	since	since	SCONJ
bionys-498	164	2	our	our	PRON
bionys-498	164	3	study	study	NOUN
bionys-498	164	4	was	be	AUX
bionys-498	164	5	conducted	conduct	VERB
bionys-498	164	6	on	on	ADP
bionys-498	164	7	relatively	relatively	ADV
bionys-498	164	8	small	small	ADJ
bionys-498	164	9	number	number	NOUN
bionys-498	164	10	of	of	ADP
bionys-498	164	11	patients	patient	NOUN
bionys-498	164	12	,	,	PUNCT
bionys-498	164	13	more	more	ADJ
bionys-498	164	14	cohort	cohort	NOUN
bionys-498	164	15	studies	study	NOUN
bionys-498	164	16	are	be	AUX
bionys-498	164	17	needed	need	VERB
bionys-498	164	18	.	.	PUNCT
bionys-498	165	1	acknowledgements	acknowledgement	NOUN
bionys-498	165	2	.	.	PUNCT
bionys-498	166	1	this	this	DET
bionys-498	166	2	work	work	NOUN
bionys-498	166	3	was	be	AUX
bionys-498	166	4	supported	support	VERB
bionys-498	166	5	by	by	ADP
bionys-498	166	6	the	the	DET
bionys-498	166	7	ministry	ministry	PROPN
bionys-498	166	8	of	of	ADP
bionys-498	166	9	education	education	PROPN
bionys-498	166	10	,	,	PUNCT
bionys-498	166	11	science	science	NOUN
bionys-498	166	12	and	and	CCONJ
bionys-498	166	13	technological	technological	ADJ
bionys-498	166	14	development	development	NOUN
bionys-498	166	15	of	of	ADP
bionys-498	166	16	the	the	DET
bionys-498	166	17	republic	republic	NOUN
bionys-498	166	18	of	of	ADP
bionys-498	166	19	serbia	serbia	PROPN
bionys-498	166	20	(	(	PUNCT
bionys-498	166	21	grant	grant	VERB
bionys-498	166	22	no	no	NOUN
bionys-498	166	23	.	.	NOUN
bionys-498	166	24	45103	45103	NUM
bionys-498	166	25	-	-	SYM
bionys-498	166	26	47/2023	47/2023	NUM
bionys-498	166	27	-	-	PUNCT
bionys-498	166	28	01/	01/	NUM
bionys-498	166	29	200124	200124	NUM
bionys-498	166	30	)	)	PUNCT
bionys-498	166	31	.	.	PUNCT
bionys-498	167	1	references	reference	NOUN
bionys-498	167	2	barber	barber	PROPN
bionys-498	167	3	,	,	PUNCT
bionys-498	167	4	t.d	t.d	PROPN
bionys-498	167	5	.	.	PROPN
bionys-498	167	6	,	,	PUNCT
bionys-498	167	7	vogelstein	vogelstein	PROPN
bionys-498	167	8	,	,	PUNCT
bionys-498	167	9	b.	b.	PROPN
bionys-498	167	10	,	,	PUNCT
bionys-498	167	11	kinzler	kinzler	PROPN
bionys-498	167	12	,	,	PUNCT
bionys-498	167	13	k.w	k.w	PROPN
bionys-498	167	14	.	.	PROPN
bionys-498	167	15	,	,	PUNCT
bionys-498	167	16	&	&	CCONJ
bionys-498	167	17	velculescu	velculescu	PROPN
bionys-498	167	18	,	,	PUNCT
bionys-498	167	19	v.e	v.e	PROPN
bionys-498	167	20	.	.	PROPN
bionys-498	167	21	(	(	PUNCT
bionys-498	167	22	2004	2004	NUM
bionys-498	167	23	)	)	PUNCT
bionys-498	167	24	.	.	PUNCT
bionys-498	168	1	somatic	somatic	ADJ
bionys-498	168	2	mutations	mutation	NOUN
bionys-498	168	3	of	of	ADP
bionys-498	168	4	egfr	egfr	NOUN
bionys-498	168	5	in	in	ADP
bionys-498	168	6	colorectal	colorectal	ADJ
bionys-498	168	7	cancers	cancer	NOUN
bionys-498	168	8	and	and	CCONJ
bionys-498	168	9	glioblastomas	glioblastoma	NOUN
bionys-498	168	10	.	.	PUNCT
bionys-498	169	1	new	new	PROPN
bionys-498	169	2	england	england	PROPN
bionys-498	169	3	journal	journal	PROPN
bionys-498	169	4	of	of	ADP
bionys-498	169	5	medicine	medicine	NOUN
bionys-498	169	6	,	,	PUNCT
bionys-498	169	7	351	351	NUM
bionys-498	169	8	-	-	SYM
bionys-498	169	9	2883	2883	NUM
bionys-498	169	10	.	.	PUNCT
bionys-498	170	1	barnes	barne	NOUN
bionys-498	170	2	,	,	PUNCT
bionys-498	170	3	p.	p.	PROPN
bionys-498	170	4	,	,	PUNCT
bionys-498	170	5	yeboah	yeboah	NOUN
bionys-498	170	6	,	,	PUNCT
bionys-498	170	7	f.a	f.a	PROPN
bionys-498	170	8	.	.	PROPN
bionys-498	170	9	,	,	PUNCT
bionys-498	170	10	zhu	zhu	PROPN
bionys-498	170	11	,	,	PUNCT
bionys-498	170	12	j.	j.	PROPN
bionys-498	170	13	,	,	PUNCT
bionys-498	170	14	saahene	saahene	PROPN
bionys-498	170	15	,	,	PUNCT
bionys-498	170	16	r.o	r.o	PROPN
bionys-498	170	17	.	.	PROPN
bionys-498	170	18	,	,	PUNCT
bionys-498	170	19	obirikorang	obirikorang	PROPN
bionys-498	170	20	,	,	PUNCT
bionys-498	170	21	c.	c.	PROPN
bionys-498	170	22	,	,	PUNCT
bionys-498	170	23	adinortey	adinortey	PROPN
bionys-498	170	24	,	,	PUNCT
bionys-498	170	25	m.b	m.b	PROPN
bionys-498	170	26	.	.	PROPN
bionys-498	170	27	,	,	PUNCT
bionys-498	170	28	amoani	amoani	PROPN
bionys-498	170	29	,	,	PUNCT
bionys-498	170	30	b.	b.	PROPN
bionys-498	170	31	,	,	PUNCT
bionys-498	170	32	kyei	kyei	PROPN
bionys-498	170	33	,	,	PUNCT
bionys-498	170	34	f.	f.	PROPN
bionys-498	170	35	,	,	PUNCT
bionys-498	170	36	akakpo	akakpo	PROPN
bionys-498	170	37	,	,	PUNCT
bionys-498	170	38	p.	p.	PROPN
bionys-498	170	39	,	,	PUNCT
bionys-498	170	40	&	&	CCONJ
bionys-498	170	41	awuku	awuku	PROPN
bionys-498	170	42	,	,	PUNCT
bionys-498	170	43	y.a	y.a	PROPN
bionys-498	170	44	.	.	PROPN
bionys-498	170	45	(	(	PUNCT
bionys-498	170	46	2020	2020	NUM
bionys-498	170	47	)	)	PUNCT
bionys-498	170	48	.	.	PUNCT
bionys-498	171	1	prognostic	prognostic	ADJ
bionys-498	171	2	worth	worth	NOUN
bionys-498	171	3	of	of	ADP
bionys-498	171	4	epidermal	epidermal	ADJ
bionys-498	171	5	growth	growth	NOUN
bionys-498	171	6	factor	factor	NOUN
bionys-498	171	7	receptor	receptor	NOUN
bionys-498	171	8	(	(	PUNCT
bionys-498	171	9	egfr	egfr	X
bionys-498	171	10	)	)	PUNCT
bionys-498	171	11	in	in	ADP
bionys-498	171	12	patients	patient	NOUN
bionys-498	171	13	with	with	ADP
bionys-498	171	14	head	head	NOUN
bionys-498	171	15	and	and	CCONJ
bionys-498	171	16	neck	neck	NOUN
bionys-498	171	17	tumors	tumor	NOUN
bionys-498	171	18	.	.	PUNCT
bionys-498	172	1	journal	journal	PROPN
bionys-498	172	2	of	of	ADP
bionys-498	172	3	cancer	cancer	NOUN
bionys-498	172	4	epidemiology	epidemiology	NOUN
bionys-498	172	5	,	,	PUNCT
bionys-498	172	6	5615303	5615303	NUM
bionys-498	172	7	.	.	PUNCT
bionys-498	173	1	campos	campos	PROPN
bionys-498	173	2	,	,	PUNCT
bionys-498	173	3	f.g	f.g	PROPN
bionys-498	173	4	.	.	PROPN
bionys-498	173	5	(	(	PUNCT
bionys-498	173	6	2017	2017	NUM
bionys-498	173	7	)	)	PUNCT
bionys-498	173	8	.	.	PUNCT
bionys-498	174	1	colorectal	colorectal	ADJ
bionys-498	174	2	cancer	cancer	NOUN
bionys-498	174	3	in	in	ADP
bionys-498	174	4	young	young	ADJ
bionys-498	174	5	adults	adult	NOUN
bionys-498	174	6	:	:	PUNCT
bionys-498	174	7	a	a	DET
bionys-498	174	8	difficult	difficult	ADJ
bionys-498	174	9	challenge	challenge	NOUN
bionys-498	174	10	.	.	PUNCT
bionys-498	175	1	world	world	NOUN
bionys-498	175	2	journal	journal	PROPN
bionys-498	175	3	of	of	ADP
bionys-498	175	4	gastroenterology	gastroenterology	NOUN
bionys-498	175	5	,	,	PUNCT
bionys-498	175	6	23	23	NUM
bionys-498	175	7	,	,	PUNCT
bionys-498	175	8	5041	5041	NUM
bionys-498	175	9	.	.	PUNCT
bionys-498	176	1	cho	cho	PROPN
bionys-498	176	2	,	,	PUNCT
bionys-498	176	3	j.	j.	PROPN
bionys-498	176	4	,	,	PUNCT
bionys-498	176	5	bass	bass	PROPN
bionys-498	176	6	,	,	PUNCT
bionys-498	176	7	a.j	a.j	PROPN
bionys-498	176	8	.	.	PROPN
bionys-498	176	9	,	,	PUNCT
bionys-498	176	10	lawrence	lawrence	PROPN
bionys-498	176	11	,	,	PUNCT
bionys-498	176	12	m.s	m.s	PROPN
bionys-498	176	13	.	.	PROPN
bionys-498	176	14	,	,	PUNCT
bionys-498	176	15	cibulskis	cibulskis	PROPN
bionys-498	176	16	,	,	PUNCT
bionys-498	176	17	k.	k.	PROPN
bionys-498	176	18	cho	cho	PROPN
bionys-498	176	19	,	,	PUNCT
bionys-498	176	20	a.	a.	PROPN
bionys-498	176	21	,	,	PUNCT
bionys-498	176	22	lee	lee	PROPN
bionys-498	176	23	,	,	PUNCT
bionys-498	176	24	s.n	s.n	PROPN
bionys-498	176	25	.	.	PROPN
bionys-498	176	26	,	,	PUNCT
bionys-498	176	27	yamauchi	yamauchi	PROPN
bionys-498	176	28	,	,	PUNCT
bionys-498	176	29	m.	m.	NOUN
bionys-498	176	30	,	,	PUNCT
bionys-498	176	31	wagle	wagle	NOUN
bionys-498	176	32	,	,	PUNCT
bionys-498	176	33	n.	n.	NOUN
bionys-498	176	34	,	,	PUNCT
bionys-498	176	35	pochanard	pochanard	NOUN
bionys-498	176	36	,	,	PUNCT
bionys-498	176	37	p.	p.	PROPN
bionys-498	176	38	,	,	PUNCT
bionys-498	176	39	kim	kim	PROPN
bionys-498	176	40	,	,	PUNCT
bionys-498	176	41	n.	n.	NOUN
bionys-498	176	42	,	,	PUNCT
bionys-498	176	43	park	park	NOUN
bionys-498	176	44	,	,	PUNCT
bionys-498	176	45	a.k.j	a.k.j	PROPN
bionys-498	176	46	.	.	PROPN
bionys-498	176	47	,	,	PUNCT
bionys-498	176	48	won	win	VERB
bionys-498	176	49	,	,	PUNCT
bionys-498	176	50	j.	j.	PROPN
bionys-498	176	51	,	,	PUNCT
bionys-498	176	52	hur	hur	PROPN
bionys-498	176	53	,	,	PUNCT
bionys-498	176	54	h.s	h.s	PROPN
bionys-498	176	55	.	.	PROPN
bionys-498	176	56	,	,	PUNCT
bionys-498	176	57	greulich	greulich	PROPN
bionys-498	176	58	,	,	PUNCT
bionys-498	176	59	h.	h.	PROPN
bionys-498	176	60	,	,	PUNCT
bionys-498	176	61	ogino	ogino	PROPN
bionys-498	176	62	,	,	PUNCT
bionys-498	176	63	s.	s.	PROPN
bionys-498	176	64	,	,	PUNCT
bionys-498	176	65	sougnez	sougnez	PROPN
bionys-498	176	66	,	,	PUNCT
bionys-498	176	67	c.	c.	PROPN
bionys-498	176	68	,	,	PUNCT
bionys-498	176	69	voet	voet	ADV
bionys-498	176	70	,	,	PUNCT
bionys-498	176	71	d.	d.	PROPN
bionys-498	176	72	,	,	PUNCT
bionys-498	176	73	tabernero	tabernero	PROPN
bionys-498	176	74	,	,	PUNCT
bionys-498	176	75	j.	j.	PROPN
bionys-498	176	76	,	,	PUNCT
bionys-498	176	77	jimenez	jimenez	PROPN
bionys-498	176	78	,	,	PUNCT
bionys-498	176	79	j.	j.	PROPN
bionys-498	176	80	,	,	PUNCT
bionys-498	176	81	baselga	baselga	PROPN
bionys-498	176	82	,	,	PUNCT
bionys-498	176	83	j.	j.	PROPN
bionys-498	176	84	,	,	PUNCT
bionys-498	176	85	gabriel	gabriel	PROPN
bionys-498	176	86	,	,	PUNCT
bionys-498	176	87	s.	s.	PROPN
bionys-498	176	88	b.	b.	PROPN
bionys-498	176	89	,	,	PUNCT
bionys-498	176	90	lander	lander	PROPN
bionys-498	176	91	,	,	PUNCT
bionys-498	176	92	e.s	e.s	PROPN
bionys-498	176	93	.	.	PROPN
bionys-498	176	94	,	,	PUNCT
bionys-498	176	95	getz	getz	PROPN
bionys-498	176	96	,	,	PUNCT
bionys-498	176	97	g.	g.	PROPN
bionys-498	176	98	,	,	PUNCT
bionys-498	176	99	eck	eck	PROPN
bionys-498	176	100	,	,	PUNCT
bionys-498	176	101	m.j	m.j	PROPN
bionys-498	176	102	.	.	PROPN
bionys-498	176	103	,	,	PUNCT
bionys-498	176	104	park	park	PROPN
bionys-498	176	105	,	,	PUNCT
bionys-498	176	106	w.y	w.y	PROPN
bionys-498	176	107	.	.	PROPN
bionys-498	176	108	,	,	PUNCT
bionys-498	176	109	&	&	CCONJ
bionys-498	176	110	meyerson	meyerson	PROPN
bionys-498	176	111	,	,	PUNCT
bionys-498	176	112	m.	m.	NOUN
bionys-498	176	113	(	(	PUNCT
bionys-498	176	114	2014	2014	NUM
bionys-498	176	115	)	)	PUNCT
bionys-498	176	116	.	.	PUNCT
bionys-498	177	1	colon	colon	NOUN
bionys-498	177	2	cancer	cancer	NOUN
bionys-498	177	3	-	-	PUNCT
bionys-498	177	4	derived	derive	VERB
bionys-498	177	5	oncogenic	oncogenic	NOUN
bionys-498	177	6	egfr	egfr	NOUN
bionys-498	177	7	g724s	g724s	PROPN
bionys-498	177	8	mutant	mutant	NOUN
bionys-498	177	9	identified	identify	VERB
bionys-498	177	10	by	by	ADP
bionys-498	177	11	whole	whole	ADJ
bionys-498	177	12	genome	genome	NOUN
bionys-498	177	13	sequence	sequence	NOUN
bionys-498	177	14	analysis	analysis	NOUN
bionys-498	177	15	is	be	AUX
bionys-498	177	16	dependent	dependent	ADJ
bionys-498	177	17	on	on	ADP
bionys-498	177	18	asymmetric	asymmetric	ADJ
bionys-498	177	19	dimerization	dimerization	NOUN
bionys-498	177	20	and	and	CCONJ
bionys-498	177	21	sensitive	sensitive	ADJ
bionys-498	177	22	to	to	ADP
bionys-498	177	23	cetuximab	cetuximab	NOUN
bionys-498	177	24	.	.	PUNCT
bionys-498	178	1	molecular	molecular	ADJ
bionys-498	178	2	cancer	cancer	NOUN
bionys-498	178	3	,	,	PUNCT
bionys-498	178	4	13	13	NUM
bionys-498	178	5	,	,	PUNCT
bionys-498	178	6	141	141	NUM
bionys-498	178	7	.	.	PUNCT
bionys-498	179	1	connel	connel	PROPN
bionys-498	179	2	,	,	PUNCT
bionys-498	179	3	l.c	l.c	PROPN
bionys-498	179	4	.	.	PROPN
bionys-498	179	5	,	,	PUNCT
bionys-498	179	6	mota	mota	PROPN
bionys-498	179	7	,	,	PUNCT
bionys-498	179	8	j.m	j.m	PROPN
bionys-498	179	9	.	.	PROPN
bionys-498	179	10	,	,	PUNCT
bionys-498	179	11	braghiroli	braghiroli	PROPN
bionys-498	179	12	,	,	PUNCT
bionys-498	179	13	m.i	m.i	PROPN
bionys-498	179	14	.	.	PROPN
bionys-498	179	15	,	,	PUNCT
bionys-498	179	16	&	&	CCONJ
bionys-498	179	17	hoffa	hoffa	PROPN
bionys-498	179	18	,	,	PUNCT
bionys-498	179	19	p.m.	p.m.	PROPN
bionys-498	179	20	(	(	PUNCT
bionys-498	179	21	2017	2017	NUM
bionys-498	179	22	)	)	PUNCT
bionys-498	179	23	.	.	PUNCT
bionys-498	180	1	the	the	DET
bionys-498	180	2	rising	rise	VERB
bionys-498	180	3	incidence	incidence	NOUN
bionys-498	180	4	of	of	ADP
bionys-498	180	5	younger	young	ADJ
bionys-498	180	6	patients	patient	NOUN
bionys-498	180	7	with	with	ADP
bionys-498	180	8	colorectal	colorectal	ADJ
bionys-498	180	9	cancer	cancer	NOUN
bionys-498	180	10	:	:	PUNCT
bionys-498	180	11	questions	question	NOUN
bionys-498	180	12	about	about	ADP
bionys-498	180	13	screening	screening	NOUN
bionys-498	180	14	,	,	PUNCT
bionys-498	180	15	biology	biology	NOUN
bionys-498	180	16	and	and	CCONJ
bionys-498	180	17	tretmant	tretmant	NOUN
bionys-498	180	18	.	.	PUNCT
bionys-498	181	1	current	current	ADJ
bionys-498	181	2	treatment	treatment	NOUN
bionys-498	181	3	options	option	NOUN
bionys-498	181	4	in	in	ADP
bionys-498	181	5	oncology	oncology	NOUN
bionys-498	181	6	,	,	PUNCT
bionys-498	181	7	18(4	18(4	NUM
bionys-498	181	8	)	)	PUNCT
bionys-498	181	9	,	,	PUNCT
bionys-498	181	10	23	23	NUM
bionys-498	181	11	.	.	PUNCT
bionys-498	182	1	del	del	PROPN
bionys-498	182	2	carmen	carmen	PROPN
bionys-498	182	3	,	,	PUNCT
bionys-498	182	4	s.	s.	PROPN
bionys-498	182	5	,	,	PUNCT
bionys-498	182	6	corchete	corchete	PROPN
bionys-498	182	7	,	,	PUNCT
bionys-498	182	8	l.a	l.a	PROPN
bionys-498	182	9	.	.	PROPN
bionys-498	182	10	,	,	PUNCT
bionys-498	182	11	gervas	gervas	PROPN
bionys-498	182	12	,	,	PUNCT
bionys-498	182	13	r.	r.	PROPN
bionys-498	182	14	,	,	PUNCT
bionys-498	182	15	rodriguez	rodriguez	PROPN
bionys-498	182	16	,	,	PUNCT
bionys-498	182	17	a.	a.	PROPN
bionys-498	182	18	,	,	PUNCT
bionys-498	182	19	garcia	garcia	PROPN
bionys-498	182	20	,	,	PUNCT
bionys-498	182	21	m.	m.	NOUN
bionys-498	182	22	,	,	PUNCT
bionys-498	182	23	álcazar	álcazar	PROPN
bionys-498	182	24	,	,	PUNCT
bionys-498	182	25	j.a	j.a	PROPN
bionys-498	182	26	.	.	PROPN
bionys-498	182	27	,	,	PUNCT
bionys-498	182	28	44	44	NUM
bionys-498	182	29	45	45	NUM
bionys-498	182	30	biologica	biologica	PROPN
bionys-498	182	31	nyssana	nyssana	PROPN
bionys-498	182	32	●	●	PUNCT
bionys-498	182	33	14	14	NUM
bionys-498	182	34	(	(	PUNCT
bionys-498	182	35	1	1	NUM
bionys-498	182	36	)	)	PUNCT
bionys-498	182	37	june	june	PROPN
bionys-498	182	38	2023	2023	NUM
bionys-498	182	39	:	:	PUNCT
bionys-498	182	40	39	39	NUM
bionys-498	182	41	-	-	SYM
bionys-498	182	42	46	46	NUM
bionys-498	182	43	koveitypour	koveitypour	NOUN
bionys-498	182	44	,	,	PUNCT
bionys-498	182	45	z.	z.	PROPN
bionys-498	182	46	,	,	PUNCT
bionys-498	182	47	panahi	panahi	PROPN
bionys-498	182	48	,	,	PUNCT
bionys-498	182	49	f.	f.	PROPN
bionys-498	182	50	,	,	PUNCT
bionys-498	182	51	vakilian	vakilian	ADJ
bionys-498	182	52	,	,	PUNCT
bionys-498	182	53	m.	m.	NOUN
bionys-498	182	54	,	,	PUNCT
bionys-498	182	55	peymani	peymani	NOUN
bionys-498	182	56	,	,	PUNCT
bionys-498	182	57	m.	m.	NOUN
bionys-498	182	58	,	,	PUNCT
bionys-498	182	59	seyed	seyed	PROPN
bionys-498	182	60	forootan	forootan	PROPN
bionys-498	182	61	,	,	PUNCT
bionys-498	182	62	f.	f.	PROPN
bionys-498	182	63	,	,	PUNCT
bionys-498	182	64	nasr	nasr	PROPN
bionys-498	182	65	esfahani	esfahani	PROPN
bionys-498	182	66	,	,	PUNCT
bionys-498	182	67	m.h	m.h	PROPN
bionys-498	182	68	.	.	PROPN
bionys-498	182	69	,	,	PUNCT
bionys-498	182	70	&	&	CCONJ
bionys-498	182	71	ghaedi	ghaedi	PROPN
bionys-498	182	72	,	,	PUNCT
bionys-498	182	73	k.	k.	PROPN
bionys-498	182	74	(	(	PUNCT
bionys-498	182	75	2019	2019	NUM
bionys-498	182	76	)	)	PUNCT
bionys-498	182	77	.	.	PUNCT
bionys-498	183	1	signaling	signal	VERB
bionys-498	183	2	pathways	pathway	NOUN
bionys-498	183	3	involved	involve	VERB
bionys-498	183	4	in	in	ADP
bionys-498	183	5	colorectal	colorectal	ADJ
bionys-498	183	6	cancer	cancer	NOUN
bionys-498	183	7	progression	progression	NOUN
bionys-498	183	8	.	.	PUNCT
bionys-498	184	1	cell	cell	NOUN
bionys-498	184	2	&	&	CCONJ
bionys-498	184	3	bioscience	bioscience	PROPN
bionys-498	184	4	,	,	PUNCT
bionys-498	184	5	9	9	NUM
bionys-498	184	6	,	,	PUNCT
bionys-498	184	7	97	97	NUM
bionys-498	184	8	.	.	PUNCT
bionys-498	185	1	liu	liu	PROPN
bionys-498	185	2	,	,	PUNCT
bionys-498	185	3	h.	h.	PROPN
bionys-498	185	4	,	,	PUNCT
bionys-498	185	5	zhang	zhang	PROPN
bionys-498	185	6	,	,	PUNCT
bionys-498	185	7	b.	b.	PROPN
bionys-498	185	8	,	,	PUNCT
bionys-498	185	9	&	&	CCONJ
bionys-498	185	10	sun	sun	PROPN
bionys-498	185	11	,	,	PUNCT
bionys-498	185	12	z.	z.	PROPN
bionys-498	185	13	(	(	PUNCT
bionys-498	185	14	2020	2020	NUM
bionys-498	185	15	)	)	PUNCT
bionys-498	185	16	.	.	PUNCT
bionys-498	186	1	spectrum	spectrum	NOUN
bionys-498	186	2	of	of	ADP
bionys-498	186	3	egfr	egfr	ADJ
bionys-498	186	4	aberrations	aberration	NOUN
bionys-498	186	5	and	and	CCONJ
bionys-498	186	6	potential	potential	ADJ
bionys-498	186	7	clinical	clinical	ADJ
bionys-498	186	8	implications	implication	NOUN
bionys-498	186	9	:	:	PUNCT
bionys-498	186	10	insights	insight	NOUN
bionys-498	186	11	from	from	ADP
bionys-498	186	12	integrative	integrative	ADJ
bionys-498	186	13	pan	pan	ADJ
bionys-498	186	14	-	-	ADJ
bionys-498	186	15	cancer	cancer	NOUN
bionys-498	186	16	analysis	analysis	NOUN
bionys-498	186	17	.	.	PUNCT
bionys-498	187	1	cancer	cancer	NOUN
bionys-498	187	2	commun	commun	PROPN
bionys-498	187	3	(	(	PUNCT
bionys-498	187	4	lond	lond	PROPN
bionys-498	187	5	)	)	PUNCT
bionys-498	187	6	,	,	PUNCT
bionys-498	187	7	40(1	40(1	NOUN
bionys-498	187	8	)	)	PUNCT
bionys-498	187	9	,	,	PUNCT
bionys-498	187	10	43	43	NUM
bionys-498	187	11	-	-	SYM
bionys-498	187	12	59	59	NUM
bionys-498	187	13	.	.	PUNCT
bionys-498	188	1	liu	liu	PROPN
bionys-498	188	2	,	,	PUNCT
bionys-498	188	3	j.	j.	PROPN
bionys-498	188	4	,	,	PUNCT
bionys-498	188	5	zhou	zhou	PROPN
bionys-498	188	6	,	,	PUNCT
bionys-498	188	7	q.	q.	PROPN
bionys-498	188	8	,	,	PUNCT
bionys-498	188	9	xu	xu	PROPN
bionys-498	188	10	,	,	PUNCT
bionys-498	188	11	j.	j.	PROPN
bionys-498	188	12	,	,	PUNCT
bionys-498	188	13	wang	wang	PROPN
bionys-498	188	14	,	,	PUNCT
bionys-498	188	15	j.	j.	PROPN
bionys-498	188	16	,	,	PUNCT
bionys-498	188	17	&	&	CCONJ
bionys-498	188	18	zhang	zhang	PROPN
bionys-498	188	19	,	,	PUNCT
bionys-498	188	20	y.	y.	PROPN
bionys-498	188	21	(	(	PUNCT
bionys-498	188	22	2016	2016	NUM
bionys-498	188	23	)	)	PUNCT
bionys-498	188	24	.	.	PUNCT
bionys-498	189	1	detection	detection	NOUN
bionys-498	189	2	of	of	ADP
bionys-498	189	3	egfr	egfr	ADJ
bionys-498	189	4	expression	expression	NOUN
bionys-498	189	5	in	in	ADP
bionys-498	189	6	patients	patient	NOUN
bionys-498	189	7	with	with	ADP
bionys-498	189	8	colorectal	colorectal	ADJ
bionys-498	189	9	cancer	cancer	NOUN
bionys-498	189	10	and	and	CCONJ
bionys-498	189	11	the	the	DET
bionys-498	189	12	therapeutic	therapeutic	ADJ
bionys-498	189	13	effect	effect	NOUN
bionys-498	189	14	of	of	ADP
bionys-498	189	15	cetuximab	cetuximab	NOUN
bionys-498	189	16	.	.	PUNCT
bionys-498	190	1	journal	journal	NOUN
bionys-498	190	2	of	of	ADP
bionys-498	190	3	b.u.on	b.u.on	PROPN
bionys-498	190	4	.	.	PUNCT
bionys-498	190	5	:	:	PUNCT
bionys-498	190	6	official	official	ADJ
bionys-498	190	7	journal	journal	NOUN
bionys-498	190	8	of	of	ADP
bionys-498	190	9	the	the	DET
bionys-498	190	10	balkan	balkan	PROPN
bionys-498	190	11	union	union	NOUN
bionys-498	190	12	of	of	ADP
bionys-498	190	13	oncology	oncology	NOUN
bionys-498	190	14	,	,	PUNCT
bionys-498	190	15	21(1	21(1	NUM
bionys-498	190	16	)	)	PUNCT
bionys-498	190	17	,	,	PUNCT
bionys-498	190	18	95–100	95–100	PROPN
bionys-498	190	19	.	.	PUNCT
bionys-498	190	20	mármol	mármol	PROPN
bionys-498	190	21	,	,	PUNCT
bionys-498	190	22	i.	i.	PROPN
bionys-498	190	23	,	,	PUNCT
bionys-498	190	24	sánchez	sánchez	PROPN
bionys-498	190	25	de	de	PROPN
bionys-498	190	26	diego	diego	PROPN
bionys-498	190	27	,	,	PUNCT
bionys-498	190	28	c.	c.	PROPN
bionys-498	190	29	,	,	PUNCT
bionys-498	190	30	pradilla	pradilla	NOUN
bionys-498	190	31	,	,	PUNCT
bionys-498	190	32	d.a	d.a	PROPN
bionys-498	190	33	.	.	PROPN
bionys-498	190	34	,	,	PUNCT
bionys-498	190	35	cerrada	cerrada	PROPN
bionys-498	190	36	,	,	PUNCT
bionys-498	190	37	e.	e.	PROPN
bionys-498	190	38	,	,	PUNCT
bionys-498	190	39	&	&	CCONJ
bionys-498	190	40	rodriguez	rodriguez	PROPN
bionys-498	190	41	yoldi	yoldi	PROPN
bionys-498	190	42	,	,	PUNCT
bionys-498	190	43	m.j	m.j	PROPN
bionys-498	190	44	.	.	PROPN
bionys-498	190	45	(	(	PUNCT
bionys-498	190	46	2017	2017	NUM
bionys-498	190	47	)	)	PUNCT
bionys-498	190	48	.	.	PUNCT
bionys-498	191	1	colorectal	colorectal	ADJ
bionys-498	191	2	carcinoma	carcinoma	NOUN
bionys-498	191	3	:	:	PUNCT
bionys-498	191	4	a	a	DET
bionys-498	191	5	general	general	ADJ
bionys-498	191	6	overview	overview	NOUN
bionys-498	191	7	and	and	CCONJ
bionys-498	191	8	future	future	ADJ
bionys-498	191	9	perspectives	perspective	NOUN
bionys-498	191	10	in	in	ADP
bionys-498	191	11	colorectal	colorectal	ADJ
bionys-498	191	12	cancer	cancer	NOUN
bionys-498	191	13	.	.	PUNCT
bionys-498	192	1	international	international	ADJ
bionys-498	192	2	journal	journal	NOUN
bionys-498	192	3	of	of	ADP
bionys-498	192	4	molecular	molecular	ADJ
bionys-498	192	5	sciences	science	NOUN
bionys-498	192	6	,	,	PUNCT
bionys-498	192	7	18(1	18(1	NOUN
bionys-498	192	8	)	)	PUNCT
bionys-498	192	9	,	,	PUNCT
bionys-498	192	10	197	197	NUM
bionys-498	192	11	.	.	PUNCT
bionys-498	193	1	mendelsohn	mendelsohn	PROPN
bionys-498	193	2	,	,	PUNCT
bionys-498	193	3	j.	j.	PROPN
bionys-498	193	4	,	,	PUNCT
bionys-498	193	5	prewett	prewett	PROPN
bionys-498	193	6	,	,	PUNCT
bionys-498	193	7	m.	m.	NOUN
bionys-498	193	8	,	,	PUNCT
bionys-498	193	9	rockwell	rockwell	PROPN
bionys-498	193	10	,	,	PUNCT
bionys-498	193	11	p.	p.	PROPN
bionys-498	193	12	,	,	PUNCT
bionys-498	193	13	&	&	CCONJ
bionys-498	193	14	goldstein	goldstein	PROPN
bionys-498	193	15	,	,	PUNCT
bionys-498	193	16	n.i	n.i	PROPN
bionys-498	193	17	.	.	PROPN
bionys-498	193	18	(	(	PUNCT
bionys-498	193	19	2015	2015	NUM
bionys-498	193	20	)	)	PUNCT
bionys-498	193	21	.	.	PUNCT
bionys-498	194	1	ccr	ccr	PROPN
bionys-498	194	2	20th	20th	ADJ
bionys-498	194	3	anniversary	anniversary	NOUN
bionys-498	194	4	commentary	commentary	NOUN
bionys-498	194	5	:	:	PUNCT
bionys-498	194	6	a	a	DET
bionys-498	194	7	chimeric	chimeric	ADJ
bionys-498	194	8	antibody	antibody	NOUN
bionys-498	194	9	,	,	PUNCT
bionys-498	194	10	c225	c225	PROPN
bionys-498	194	11	,	,	PUNCT
bionys-498	194	12	inhibits	inhibit	VERB
bionys-498	194	13	egfr	egfr	ADJ
bionys-498	194	14	activation	activation	NOUN
bionys-498	194	15	and	and	CCONJ
bionys-498	194	16	tumor	tumor	NOUN
bionys-498	194	17	growth	growth	NOUN
bionys-498	194	18	.	.	PUNCT
bionys-498	195	1	clinical	clinical	ADJ
bionys-498	195	2	cancer	cancer	NOUN
bionys-498	195	3	research	research	NOUN
bionys-498	195	4	,	,	PUNCT
bionys-498	195	5	21(2	21(2	NUM
bionys-498	195	6	)	)	PUNCT
bionys-498	195	7	,	,	PUNCT
bionys-498	195	8	227–9	227–9	NUM
bionys-498	195	9	.	.	PUNCT
bionys-498	196	1	metzger	metzger	PROPN
bionys-498	196	2	,	,	PUNCT
bionys-498	196	3	b.	b.	PROPN
bionys-498	196	4	,	,	PUNCT
bionys-498	196	5	chambeau	chambeau	PROPN
bionys-498	196	6	,	,	PUNCT
bionys-498	196	7	l.	l.	PROPN
bionys-498	196	8	,	,	PUNCT
bionys-498	196	9	begon	begon	PROPN
bionys-498	196	10	,	,	PUNCT
bionys-498	196	11	d.y	d.y	PROPN
bionys-498	196	12	.	.	PROPN
bionys-498	196	13	,	,	PUNCT
bionys-498	196	14	faber	faber	PROPN
bionys-498	196	15	,	,	PUNCT
bionys-498	196	16	c.	c.	PROPN
bionys-498	196	17	,	,	PUNCT
bionys-498	196	18	kayser	kayser	PROPN
bionys-498	196	19	,	,	PUNCT
bionys-498	196	20	j.	j.	PROPN
bionys-498	196	21	,	,	PUNCT
bionys-498	196	22	berchem	berchem	PROPN
bionys-498	196	23	,	,	PUNCT
bionys-498	196	24	g.	g.	PROPN
bionys-498	196	25	,	,	PUNCT
bionys-498	196	26	pauly	pauly	PROPN
bionys-498	196	27	,	,	PUNCT
bionys-498	196	28	m.	m.	NOUN
bionys-498	196	29	,	,	PUNCT
bionys-498	196	30	boniver	boniver	PROPN
bionys-498	196	31	,	,	PUNCT
bionys-498	196	32	j.	j.	PROPN
bionys-498	196	33	,	,	PUNCT
bionys-498	196	34	delvenne	delvenne	NOUN
bionys-498	196	35	,	,	PUNCT
bionys-498	196	36	p.	p.	NOUN
bionys-498	196	37	,	,	PUNCT
bionys-498	196	38	dicato	dicato	NOUN
bionys-498	196	39	,	,	PUNCT
bionys-498	196	40	m.	m.	NOUN
bionys-498	196	41	,	,	PUNCT
bionys-498	196	42	&	&	CCONJ
bionys-498	196	43	wenner	wenner	NOUN
bionys-498	196	44	,	,	PUNCT
bionys-498	196	45	t.	t.	PROPN
bionys-498	196	46	(	(	PUNCT
bionys-498	196	47	2011	2011	NUM
bionys-498	196	48	)	)	PUNCT
bionys-498	196	49	.	.	PUNCT
bionys-498	197	1	the	the	DET
bionys-498	197	2	human	human	ADJ
bionys-498	197	3	epidermal	epidermal	ADJ
bionys-498	197	4	growth	growth	NOUN
bionys-498	197	5	factor	factor	NOUN
bionys-498	197	6	receptor	receptor	NOUN
bionys-498	197	7	(	(	PUNCT
bionys-498	197	8	egfr	egfr	X
bionys-498	197	9	)	)	PUNCT
bionys-498	197	10	gene	gene	NOUN
bionys-498	197	11	in	in	ADP
bionys-498	197	12	european	european	ADJ
bionys-498	197	13	patients	patient	NOUN
bionys-498	197	14	with	with	ADP
bionys-498	197	15	advanced	advanced	ADJ
bionys-498	197	16	colorectal	colorectal	ADJ
bionys-498	197	17	cancer	cancer	NOUN
bionys-498	197	18	harbors	harbor	VERB
bionys-498	197	19	infrequent	infrequent	ADJ
bionys-498	197	20	mutations	mutation	NOUN
bionys-498	197	21	in	in	ADP
bionys-498	197	22	its	its	PRON
bionys-498	197	23	tyrosine	tyrosine	NOUN
bionys-498	197	24	kinase	kinase	NOUN
bionys-498	197	25	domain	domain	PROPN
bionys-498	197	26	.	.	PUNCT
bionys-498	198	1	bmc	bmc	ADJ
bionys-498	198	2	medical	medical	ADJ
bionys-498	198	3	genetics	genetic	NOUN
bionys-498	198	4	,	,	PUNCT
bionys-498	198	5	12	12	NUM
bionys-498	198	6	,	,	PUNCT
bionys-498	198	7	144	144	NUM
bionys-498	198	8	.	.	PUNCT
bionys-498	199	1	montagut	montagut	PROPN
bionys-498	199	2	,	,	PUNCT
bionys-498	199	3	c.	c.	PROPN
bionys-498	199	4	,	,	PUNCT
bionys-498	199	5	dalmases	dalmase	VERB
bionys-498	199	6	,	,	PUNCT
bionys-498	199	7	a.	a.	NOUN
bionys-498	199	8	,	,	PUNCT
bionys-498	199	9	bellosillo	bellosillo	PROPN
bionys-498	199	10	,	,	PUNCT
bionys-498	199	11	b.	b.	PROPN
bionys-498	199	12	,	,	PUNCT
bionys-498	199	13	crespo	crespo	PROPN
bionys-498	199	14	,	,	PUNCT
bionys-498	199	15	m.	m.	NOUN
bionys-498	199	16	,	,	PUNCT
bionys-498	199	17	pairet	pairet	VERB
bionys-498	199	18	,	,	PUNCT
bionys-498	199	19	s.	s.	PROPN
bionys-498	199	20	,	,	PUNCT
bionys-498	199	21	iglesias	iglesias	PROPN
bionys-498	199	22	,	,	PUNCT
bionys-498	199	23	m.	m.	NOUN
bionys-498	199	24	,	,	PUNCT
bionys-498	199	25	salido	salido	PROPN
bionys-498	199	26	,	,	PUNCT
bionys-498	199	27	m.	m.	NOUN
bionys-498	199	28	,	,	PUNCT
bionys-498	199	29	gallen	gallen	PROPN
bionys-498	199	30	,	,	PUNCT
bionys-498	199	31	m.	m.	NOUN
bionys-498	199	32	,	,	PUNCT
bionys-498	199	33	marsters	marster	NOUN
bionys-498	199	34	,	,	PUNCT
bionys-498	199	35	s.	s.	PROPN
bionys-498	199	36	,	,	PUNCT
bionys-498	199	37	tsai	tsai	PROPN
bionys-498	199	38	,	,	PUNCT
bionys-498	199	39	s.p	s.p	PROPN
bionys-498	199	40	.	.	PROPN
bionys-498	199	41	,	,	PUNCT
bionys-498	199	42	minoche	minoche	NOUN
bionys-498	199	43	,	,	PUNCT
bionys-498	199	44	a.	a.	NOUN
bionys-498	199	45	,	,	PUNCT
bionys-498	199	46	seshagiri	seshagiri	ADV
bionys-498	199	47	,	,	PUNCT
bionys-498	199	48	s.	s.	PROPN
bionys-498	199	49	,	,	PUNCT
bionys-498	199	50	serrano	serrano	PROPN
bionys-498	199	51	,	,	PUNCT
bionys-498	199	52	s.	s.	PROPN
bionys-498	199	53	,	,	PUNCT
bionys-498	199	54	himmelbauer	himmelbauer	PROPN
bionys-498	199	55	,	,	PUNCT
bionys-498	199	56	h.	h.	PROPN
bionys-498	199	57	,	,	PUNCT
bionys-498	199	58	bellmunt	bellmunt	NOUN
bionys-498	199	59	,	,	PUNCT
bionys-498	199	60	j.	j.	PROPN
bionys-498	199	61	,	,	PUNCT
bionys-498	199	62	rovira	rovira	PROPN
bionys-498	199	63	,	,	PUNCT
bionys-498	199	64	a.	a.	NOUN
bionys-498	199	65	,	,	PUNCT
bionys-498	199	66	settleman	settleman	ADJ
bionys-498	199	67	,	,	PUNCT
bionys-498	199	68	j.	j.	PROPN
bionys-498	199	69	,	,	PUNCT
bionys-498	199	70	bosch	bosch	PROPN
bionys-498	199	71	,	,	PUNCT
bionys-498	199	72	f.	f.	PROPN
bionys-498	199	73	,	,	PUNCT
bionys-498	199	74	&	&	CCONJ
bionys-498	199	75	albanell	albanell	PROPN
bionys-498	199	76	,	,	PUNCT
bionys-498	199	77	j.	j.	PROPN
bionys-498	199	78	(	(	PUNCT
bionys-498	199	79	2012	2012	NUM
bionys-498	199	80	)	)	PUNCT
bionys-498	199	81	.	.	PUNCT
bionys-498	200	1	identification	identification	NOUN
bionys-498	200	2	of	of	ADP
bionys-498	200	3	a	a	DET
bionys-498	200	4	mutation	mutation	NOUN
bionys-498	200	5	in	in	ADP
bionys-498	200	6	the	the	DET
bionys-498	200	7	extracellular	extracellular	ADJ
bionys-498	200	8	domain	domain	NOUN
bionys-498	200	9	of	of	ADP
bionys-498	200	10	the	the	DET
bionys-498	200	11	epidermal	epidermal	ADJ
bionys-498	200	12	growth	growth	NOUN
bionys-498	200	13	factor	factor	NOUN
bionys-498	200	14	receptor	receptor	NOUN
bionys-498	200	15	conferring	confer	VERB
bionys-498	200	16	cetuximab	cetuximab	NOUN
bionys-498	200	17	resistance	resistance	NOUN
bionys-498	200	18	in	in	ADP
bionys-498	200	19	colorectal	colorectal	ADJ
bionys-498	200	20	cancer	cancer	NOUN
bionys-498	200	21	.	.	PUNCT
bionys-498	201	1	nature	nature	NOUN
bionys-498	201	2	medicine	medicine	NOUN
bionys-498	201	3	,	,	PUNCT
bionys-498	201	4	18(2	18(2	NUM
bionys-498	201	5	)	)	PUNCT
bionys-498	201	6	,	,	PUNCT
bionys-498	201	7	221–223	221–223	NUM
bionys-498	201	8	.	.	PUNCT
bionys-498	202	1	moroni	moroni	PROPN
bionys-498	202	2	,	,	PUNCT
bionys-498	202	3	m.	m.	NOUN
bionys-498	202	4	,	,	PUNCT
bionys-498	202	5	veronese	veronese	NOUN
bionys-498	202	6	,	,	PUNCT
bionys-498	202	7	s.	s.	PROPN
bionys-498	202	8	,	,	PUNCT
bionys-498	202	9	benvenuti	benvenuti	PROPN
bionys-498	202	10	,	,	PUNCT
bionys-498	202	11	s.	s.	PROPN
bionys-498	202	12	,	,	PUNCT
bionys-498	202	13	marrapese	marrapese	PROPN
bionys-498	202	14	,	,	PUNCT
bionys-498	202	15	g.	g.	PROPN
bionys-498	202	16	,	,	PUNCT
bionys-498	202	17	sartore	sartore	NOUN
bionys-498	202	18	-	-	PUNCT
bionys-498	202	19	bianchi	bianchi	NOUN
bionys-498	202	20	,	,	PUNCT
bionys-498	202	21	a.	a.	NOUN
bionys-498	202	22	,	,	PUNCT
bionys-498	202	23	di	di	NOUN
bionys-498	202	24	nicolantonio	nicolantonio	PROPN
bionys-498	202	25	,	,	PUNCT
bionys-498	202	26	f.	f.	PROPN
bionys-498	202	27	,	,	PUNCT
bionys-498	202	28	gambacorta	gambacorta	PROPN
bionys-498	202	29	,	,	PUNCT
bionys-498	202	30	m.	m.	NOUN
bionys-498	202	31	,	,	PUNCT
bionys-498	202	32	siena	siena	PROPN
bionys-498	202	33	,	,	PUNCT
bionys-498	202	34	s.	s.	PROPN
bionys-498	202	35	,	,	PUNCT
bionys-498	202	36	&	&	CCONJ
bionys-498	202	37	bardelli	bardelli	PROPN
bionys-498	202	38	,	,	PUNCT
bionys-498	202	39	a.	a.	NOUN
bionys-498	202	40	(	(	PUNCT
bionys-498	202	41	2005	2005	NUM
bionys-498	202	42	)	)	PUNCT
bionys-498	202	43	.	.	PUNCT
bionys-498	203	1	gene	gene	NOUN
bionys-498	203	2	copy	copy	VERB
bionys-498	203	3	number	number	NOUN
bionys-498	203	4	for	for	ADP
bionys-498	203	5	epidermal	epidermal	ADJ
bionys-498	203	6	growth	growth	NOUN
bionys-498	203	7	factor	factor	NOUN
bionys-498	203	8	receptor	receptor	NOUN
bionys-498	203	9	(	(	PUNCT
bionys-498	203	10	egfr	egfr	X
bionys-498	203	11	)	)	PUNCT
bionys-498	203	12	and	and	CCONJ
bionys-498	203	13	clinical	clinical	ADJ
bionys-498	203	14	response	response	NOUN
bionys-498	203	15	to	to	PART
bionys-498	203	16	antiegfr	antiegfr	VERB
bionys-498	203	17	treatment	treatment	NOUN
bionys-498	203	18	in	in	ADP
bionys-498	203	19	colorectal	colorectal	ADJ
bionys-498	203	20	cancer	cancer	NOUN
bionys-498	203	21	:	:	PUNCT
bionys-498	203	22	a	a	DET
bionys-498	203	23	cohort	cohort	NOUN
bionys-498	203	24	study	study	NOUN
bionys-498	203	25	.	.	PUNCT
bionys-498	204	1	the	the	DET
bionys-498	204	2	lancet	lancet	PROPN
bionys-498	204	3	.	.	PUNCT
bionys-498	205	1	oncology	oncology	NOUN
bionys-498	205	2	,	,	PUNCT
bionys-498	205	3	6(5	6(5	NUM
bionys-498	205	4	)	)	PUNCT
bionys-498	205	5	,	,	PUNCT
bionys-498	205	6	279–286	279–286	NUM
bionys-498	205	7	.	.	PUNCT
bionys-498	206	1	mosesson	mosesson	PROPN
bionys-498	206	2	y.	y.	PROPN
bionys-498	206	3	,	,	PUNCT
bionys-498	206	4	mills	mills	PROPN
bionys-498	206	5	g.b	g.b	PROPN
bionys-498	206	6	.	.	PROPN
bionys-498	206	7	,	,	PUNCT
bionys-498	206	8	&	&	CCONJ
bionys-498	206	9	yarden	yarden	PROPN
bionys-498	206	10	,	,	PUNCT
bionys-498	206	11	y.	y.	PROPN
bionys-498	206	12	(	(	PUNCT
bionys-498	206	13	2008	2008	NUM
bionys-498	206	14	)	)	PUNCT
bionys-498	206	15	.	.	PUNCT
bionys-498	206	16	derailed	derail	VERB
bionys-498	206	17	endocytosis	endocytosis	NOUN
bionys-498	206	18	:	:	PUNCT
bionys-498	206	19	an	an	DET
bionys-498	206	20	emerging	emerge	VERB
bionys-498	206	21	feature	feature	NOUN
bionys-498	206	22	of	of	ADP
bionys-498	206	23	cancer	cancer	NOUN
bionys-498	206	24	.	.	PUNCT
bionys-498	207	1	nature	nature	NOUN
bionys-498	207	2	reviews	review	NOUN
bionys-498	207	3	.	.	PUNCT
bionys-498	208	1	cancer	cancer	NOUN
bionys-498	208	2	,	,	PUNCT
bionys-498	208	3	8(11	8(11	NUM
bionys-498	208	4	)	)	PUNCT
bionys-498	208	5	,	,	PUNCT
bionys-498	208	6	835–850	835–850	NUM
bionys-498	208	7	.	.	PUNCT
bionys-498	209	1	ogino	ogino	PROPN
bionys-498	209	2	,	,	PUNCT
bionys-498	209	3	s.	s.	PROPN
bionys-498	209	4	,	,	PUNCT
bionys-498	209	5	meyerhardt	meyerhardt	PROPN
bionys-498	209	6	,	,	PUNCT
bionys-498	209	7	j.a	j.a	PROPN
bionys-498	209	8	.	.	PROPN
bionys-498	209	9	,	,	PUNCT
bionys-498	209	10	cantor	cantor	PROPN
bionys-498	209	11	,	,	PUNCT
bionys-498	209	12	m.	m.	NOUN
bionys-498	209	13	,	,	PUNCT
bionys-498	209	14	brahmandam	brahmandam	NOUN
bionys-498	209	15	,	,	PUNCT
bionys-498	209	16	m.	m.	NOUN
bionys-498	209	17	,	,	PUNCT
bionys-498	209	18	clark	clark	PROPN
bionys-498	209	19	,	,	PUNCT
bionys-498	209	20	j.w	j.w	PROPN
bionys-498	209	21	.	.	PROPN
bionys-498	209	22	,	,	PUNCT
bionys-498	209	23	namgyal	namgyal	PROPN
bionys-498	209	24	,	,	PUNCT
bionys-498	209	25	c.	c.	PROPN
bionys-498	209	26	,	,	PUNCT
bionys-498	209	27	kawasaki	kawasaki	PROPN
bionys-498	209	28	,	,	PUNCT
bionys-498	209	29	t.	t.	PROPN
bionys-498	209	30	,	,	PUNCT
bionys-498	209	31	kinsella	kinsella	PROPN
bionys-498	209	32	,	,	PUNCT
bionys-498	209	33	k.	k.	PROPN
bionys-498	209	34	,	,	PUNCT
bionys-498	209	35	michelini	michelini	PROPN
bionys-498	209	36	,	,	PUNCT
bionys-498	209	37	a.l	a.l	PROPN
bionys-498	209	38	.	.	PROPN
bionys-498	209	39	,	,	PUNCT
bionys-498	209	40	enzinger	enzinger	NOUN
bionys-498	209	41	,	,	PUNCT
bionys-498	209	42	p.c	p.c	PROPN
bionys-498	209	43	.	.	PROPN
bionys-498	209	44	,	,	PUNCT
bionys-498	209	45	kulke	kulke	PROPN
bionys-498	209	46	,	,	PUNCT
bionys-498	209	47	m.h	m.h	PROPN
bionys-498	209	48	.	.	PROPN
bionys-498	209	49	,	,	PUNCT
bionys-498	209	50	ryan	ryan	PROPN
bionys-498	209	51	,	,	PUNCT
bionys-498	209	52	d.p	d.p	PROPN
bionys-498	209	53	.	.	PROPN
bionys-498	209	54	,	,	PUNCT
bionys-498	209	55	loda	loda	PROPN
bionys-498	209	56	,	,	PUNCT
bionys-498	209	57	m.	m.	NOUN
bionys-498	209	58	,	,	PUNCT
bionys-498	209	59	&	&	CCONJ
bionys-498	209	60	fuchs	fuchs	PROPN
bionys-498	209	61	,	,	PUNCT
bionys-498	209	62	c.s	c.s	PROPN
bionys-498	209	63	.	.	PROPN
bionys-498	209	64	(	(	PUNCT
bionys-498	209	65	2005	2005	NUM
bionys-498	209	66	)	)	PUNCT
bionys-498	209	67	.	.	PUNCT
bionys-498	210	1	molecular	molecular	ADJ
bionys-498	210	2	alterations	alteration	NOUN
bionys-498	210	3	in	in	ADP
bionys-498	210	4	tumors	tumor	NOUN
bionys-498	210	5	and	and	CCONJ
bionys-498	210	6	response	response	NOUN
bionys-498	210	7	to	to	PART
bionys-498	210	8	combination	combination	VERB
bionys-498	210	9	chemotherapy	chemotherapy	NOUN
bionys-498	210	10	with	with	ADP
bionys-498	210	11	gefitinib	gefitinib	NOUN
bionys-498	210	12	for	for	ADP
bionys-498	210	13	advanced	advanced	ADJ
bionys-498	210	14	colorectal	colorectal	ADJ
bionys-498	210	15	cancer	cancer	NOUN
bionys-498	210	16	.	.	PUNCT
bionys-498	211	1	clinical	clinical	ADJ
bionys-498	211	2	cancer	cancer	NOUN
bionys-498	211	3	research	research	NOUN
bionys-498	211	4	:	:	PUNCT
bionys-498	211	5	an	an	DET
bionys-498	211	6	official	official	ADJ
bionys-498	211	7	journal	journal	NOUN
bionys-498	211	8	of	of	ADP
bionys-498	211	9	the	the	DET
bionys-498	211	10	american	american	PROPN
bionys-498	211	11	association	association	PROPN
bionys-498	211	12	for	for	ADP
bionys-498	211	13	cancer	cancer	NOUN
bionys-498	211	14	research	research	NOUN
bionys-498	211	15	,	,	PUNCT
bionys-498	211	16	11(18	11(18	NUM
bionys-498	211	17	)	)	PUNCT
bionys-498	211	18	,	,	PUNCT
bionys-498	211	19	6650–6656	6650–6656	NUM
bionys-498	211	20	.	.	PUNCT
bionys-498	212	1	oh	oh	INTJ
bionys-498	212	2	,	,	PUNCT
bionys-498	212	3	b.y	b.y	PROPN
bionys-498	212	4	.	.	PROPN
bionys-498	212	5	,	,	PUNCT
bionys-498	212	6	lee	lee	PROPN
bionys-498	212	7	,	,	PUNCT
bionys-498	212	8	r.a	r.a	PROPN
bionys-498	212	9	.	.	PROPN
bionys-498	212	10	,	,	PUNCT
bionys-498	212	11	chung	chung	PROPN
bionys-498	212	12	,	,	PUNCT
bionys-498	212	13	s.s	s.s	PROPN
bionys-498	212	14	.	.	PROPN
bionys-498	212	15	,	,	PUNCT
bionys-498	212	16	&	&	CCONJ
bionys-498	212	17	kim	kim	PROPN
bionys-498	212	18	,	,	PUNCT
bionys-498	212	19	k.h	k.h	PROPN
bionys-498	212	20	.	.	PUNCT
bionys-498	213	1	(	(	PUNCT
bionys-498	213	2	2011	2011	NUM
bionys-498	213	3	)	)	PUNCT
bionys-498	213	4	.	.	PUNCT
bionys-498	214	1	epidermal	epidermal	ADJ
bionys-498	214	2	growth	growth	NOUN
bionys-498	214	3	factor	factor	NOUN
bionys-498	214	4	receptor	receptor	NOUN
bionys-498	214	5	mutations	mutation	NOUN
bionys-498	214	6	in	in	ADP
bionys-498	214	7	colorectal	colorectal	ADJ
bionys-498	214	8	cancer	cancer	NOUN
bionys-498	214	9	patients	patient	NOUN
bionys-498	214	10	.	.	PUNCT
bionys-498	215	1	journal	journal	NOUN
bionys-498	215	2	of	of	ADP
bionys-498	215	3	the	the	DET
bionys-498	215	4	korean	korean	ADJ
bionys-498	215	5	society	society	NOUN
bionys-498	215	6	of	of	ADP
bionys-498	215	7	coloproctology	coloproctology	NOUN
bionys-498	215	8	,	,	PUNCT
bionys-498	215	9	27(3	27(3	NUM
bionys-498	215	10	)	)	PUNCT
bionys-498	215	11	,	,	PUNCT
bionys-498	215	12	127–132	127–132	NUM
bionys-498	215	13	.	.	PUNCT
bionys-498	216	1	phua	phua	PROPN
bionys-498	216	2	,	,	PUNCT
bionys-498	216	3	l.c	l.c	PROPN
bionys-498	216	4	.	.	PROPN
bionys-498	216	5	,	,	PUNCT
bionys-498	216	6	ng	ng	PROPN
bionys-498	216	7	,	,	PUNCT
bionys-498	216	8	h.w	h.w	PROPN
bionys-498	216	9	.	.	PROPN
bionys-498	216	10	,	,	PUNCT
bionys-498	216	11	yeo	yeo	PROPN
bionys-498	216	12	,	,	PUNCT
bionys-498	216	13	a.h	a.h	PROPN
bionys-498	216	14	.	.	PROPN
bionys-498	216	15	,	,	PUNCT
bionys-498	216	16	chen	chen	PROPN
bionys-498	216	17	,	,	PUNCT
bionys-498	216	18	e.	e.	PROPN
bionys-498	216	19	,	,	PUNCT
bionys-498	216	20	lo	lo	PROPN
bionys-498	216	21	,	,	PUNCT
bionys-498	216	22	m.s	m.s	PROPN
bionys-498	216	23	.	.	PROPN
bionys-498	216	24	,	,	PUNCT
bionys-498	216	25	cheah	cheah	PROPN
bionys-498	216	26	,	,	PUNCT
bionys-498	216	27	p.y	p.y	PROPN
bionys-498	216	28	.	.	PROPN
bionys-498	216	29	,	,	PUNCT
bionys-498	216	30	chan	chan	PROPN
bionys-498	216	31	,	,	PUNCT
bionys-498	216	32	e.c	e.c	PROPN
bionys-498	216	33	.	.	PROPN
bionys-498	216	34	,	,	PUNCT
bionys-498	216	35	koh	koh	PROPN
bionys-498	216	36	,	,	PUNCT
bionys-498	216	37	p.k	p.k	PROPN
bionys-498	216	38	.	.	PROPN
bionys-498	216	39	,	,	PUNCT
bionys-498	216	40	&	&	CCONJ
bionys-498	216	41	ho	ho	PROPN
bionys-498	216	42	,	,	PUNCT
bionys-498	216	43	h.k	h.k	PROPN
bionys-498	216	44	.	.	PROPN
bionys-498	216	45	(	(	PUNCT
bionys-498	216	46	2015	2015	NUM
bionys-498	216	47	)	)	PUNCT
bionys-498	216	48	.	.	PUNCT
bionys-498	217	1	prevalence	prevalence	NOUN
bionys-498	217	2	of	of	ADP
bionys-498	217	3	kras	kras	PROPN
bionys-498	217	4	,	,	PUNCT
bionys-498	217	5	braf	braf	NOUN
bionys-498	217	6	,	,	PUNCT
bionys-498	217	7	pi3k	pi3k	PROPN
bionys-498	217	8	and	and	CCONJ
bionys-498	217	9	egfr	egfr	ADJ
bionys-498	217	10	mutations	mutation	NOUN
bionys-498	217	11	among	among	ADP
bionys-498	217	12	asian	asian	ADJ
bionys-498	217	13	patients	patient	NOUN
bionys-498	217	14	with	with	ADP
bionys-498	217	15	metastatic	metastatic	ADJ
bionys-498	217	16	colorectal	colorectal	ADJ
bionys-498	217	17	cancer	cancer	NOUN
bionys-498	217	18	.	.	PUNCT
bionys-498	218	1	oncology	oncology	NOUN
bionys-498	218	2	letters	letter	NOUN
bionys-498	218	3	,	,	PUNCT
bionys-498	218	4	10(4	10(4	NUM
bionys-498	218	5	)	)	PUNCT
bionys-498	218	6	,	,	PUNCT
bionys-498	218	7	2519–2526	2519–2526	NUM
bionys-498	218	8	.	.	PUNCT
bionys-498	219	1	porru	porru	NOUN
bionys-498	219	2	,	,	PUNCT
bionys-498	219	3	m.	m.	NOUN
bionys-498	219	4	,	,	PUNCT
bionys-498	219	5	pompili	pompili	NOUN
bionys-498	219	6	,	,	PUNCT
bionys-498	219	7	l.	l.	PROPN
bionys-498	219	8	,	,	PUNCT
bionys-498	219	9	caruso	caruso	PROPN
bionys-498	219	10	,	,	PUNCT
bionys-498	219	11	c.	c.	PROPN
bionys-498	219	12	,	,	PUNCT
bionys-498	219	13	biroccio	biroccio	NOUN
bionys-498	219	14	,	,	PUNCT
bionys-498	219	15	a.	a.	NOUN
bionys-498	219	16	,	,	PUNCT
bionys-498	219	17	&	&	CCONJ
bionys-498	219	18	leonetti	leonetti	PROPN
bionys-498	219	19	,	,	PUNCT
bionys-498	219	20	c.	c.	PROPN
bionys-498	219	21	(	(	PUNCT
bionys-498	219	22	2018	2018	NUM
bionys-498	219	23	)	)	PUNCT
bionys-498	219	24	.	.	PUNCT
bionys-498	220	1	targeting	target	VERB
bionys-498	220	2	kras	kra	NOUN
bionys-498	220	3	in	in	ADP
bionys-498	220	4	metastatic	metastatic	ADJ
bionys-498	220	5	colorectal	colorectal	ADJ
bionys-498	220	6	cancer	cancer	NOUN
bionys-498	220	7	:	:	PUNCT
bionys-498	220	8	current	current	ADJ
bionys-498	220	9	strategies	strategy	NOUN
bionys-498	220	10	and	and	CCONJ
bionys-498	220	11	emerging	emerge	VERB
bionys-498	220	12	opportunities	opportunity	NOUN
bionys-498	220	13	.	.	PUNCT
bionys-498	221	1	journal	journal	NOUN
bionys-498	221	2	of	of	ADP
bionys-498	221	3	experimental	experimental	PROPN
bionys-498	221	4	&	&	CCONJ
bionys-498	221	5	clinical	clinical	ADJ
bionys-498	221	6	cancer	cancer	NOUN
bionys-498	221	7	research	research	NOUN
bionys-498	221	8	:	:	PUNCT
bionys-498	221	9	cr	cr	PROPN
bionys-498	221	10	,	,	PUNCT
bionys-498	221	11	37(1	37(1	NUM
bionys-498	221	12	)	)	PUNCT
bionys-498	221	13	,	,	PUNCT
bionys-498	221	14	57	57	NUM
bionys-498	221	15	.	.	PUNCT
bionys-498	222	1	randon	randon	NOUN
bionys-498	222	2	,	,	PUNCT
bionys-498	222	3	g.	g.	PROPN
bionys-498	222	4	,	,	PUNCT
bionys-498	222	5	yaeger	yaeger	PROPN
bionys-498	222	6	,	,	PUNCT
bionys-498	222	7	r.	r.	PROPN
bionys-498	222	8	,	,	PUNCT
bionys-498	222	9	hechtman	hechtman	PROPN
bionys-498	222	10	,	,	PUNCT
bionys-498	222	11	j.f	j.f	PROPN
bionys-498	222	12	.	.	PROPN
bionys-498	222	13	,	,	PUNCT
bionys-498	222	14	manca	manca	PROPN
bionys-498	222	15	,	,	PUNCT
bionys-498	222	16	p.	p.	NOUN
bionys-498	222	17	,	,	PUNCT
bionys-498	222	18	fucà	fucà	PROPN
bionys-498	222	19	,	,	PUNCT
bionys-498	222	20	g.	g.	PROPN
bionys-498	222	21	,	,	PUNCT
bionys-498	222	22	walch	walch	NOUN
bionys-498	222	23	,	,	PUNCT
bionys-498	222	24	h.	h.	PROPN
bionys-498	222	25	,	,	PUNCT
bionys-498	222	26	lee	lee	PROPN
bionys-498	222	27	,	,	PUNCT
bionys-498	222	28	j.	j.	PROPN
bionys-498	222	29	,	,	PUNCT
bionys-498	222	30	élez	élez	PROPN
bionys-498	222	31	,	,	PUNCT
bionys-498	222	32	e.	e.	PROPN
bionys-498	222	33	,	,	PUNCT
bionys-498	222	34	seligmann	seligmann	PROPN
bionys-498	222	35	,	,	PUNCT
bionys-498	222	36	j.	j.	PROPN
bionys-498	222	37	,	,	PUNCT
bionys-498	222	38	mussolin	mussolin	PROPN
bionys-498	222	39	,	,	PUNCT
bionys-498	222	40	b.	b.	PROPN
bionys-498	222	41	,	,	PUNCT
bionys-498	222	42	pagani	pagani	PROPN
bionys-498	222	43	,	,	PUNCT
bionys-498	222	44	f.	f.	PROPN
bionys-498	222	45	,	,	PUNCT
bionys-498	222	46	germani	germani	PROPN
bionys-498	222	47	,	,	PUNCT
bionys-498	222	48	m.m	m.m	PROPN
bionys-498	222	49	.	.	PROPN
bionys-498	222	50	,	,	PUNCT
bionys-498	222	51	ambrosini	ambrosini	PROPN
bionys-498	222	52	,	,	PUNCT
bionys-498	222	53	m.	m.	NOUN
bionys-498	222	54	,	,	PUNCT
bionys-498	222	55	rossini	rossini	PROPN
bionys-498	222	56	,	,	PUNCT
bionys-498	222	57	d.	d.	PROPN
bionys-498	222	58	,	,	PUNCT
bionys-498	222	59	ratti	ratti	PROPN
bionys-498	222	60	,	,	PUNCT
bionys-498	222	61	m.	m.	NOUN
bionys-498	222	62	,	,	PUNCT
bionys-498	222	63	salvà	salvà	PROPN
bionys-498	222	64	,	,	PUNCT
bionys-498	222	65	f.	f.	PROPN
bionys-498	222	66	,	,	PUNCT
bionys-498	222	67	richman	richman	PROPN
bionys-498	222	68	,	,	PUNCT
bionys-498	222	69	s.d	s.d	PROPN
bionys-498	222	70	.	.	PROPN
bionys-498	222	71	,	,	PUNCT
bionys-498	222	72	wood	wood	PROPN
bionys-498	222	73	,	,	PUNCT
bionys-498	222	74	h.	h.	PROPN
bionys-498	222	75	,	,	PUNCT
bionys-498	222	76	nanjangud	nanjangud	PROPN
bionys-498	222	77	,	,	PUNCT
bionys-498	222	78	g.	g.	PROPN
bionys-498	222	79	,	,	PUNCT
bionys-498	222	80	gloghini	gloghini	PROPN
bionys-498	222	81	,	,	PUNCT
bionys-498	222	82	a.	a.	NOUN
bionys-498	222	83	,	,	PUNCT
bionys-498	222	84	milione	milione	PROPN
bionys-498	222	85	,	,	PUNCT
bionys-498	222	86	m.	m.	NOUN
bionys-498	222	87	,	,	PUNCT
bionys-498	222	88	bardelli	bardelli	NOUN
bionys-498	222	89	,	,	PUNCT
bionys-498	222	90	a.	a.	NOUN
bionys-498	222	91	,	,	PUNCT
bionys-498	222	92	de	de	X
bionys-498	222	93	braud	braud	PROPN
bionys-498	222	94	,	,	PUNCT
bionys-498	222	95	f.	f.	PROPN
bionys-498	222	96	,	,	PUNCT
bionys-498	222	97	morano	morano	PROPN
bionys-498	222	98	,	,	PUNCT
bionys-498	222	99	f.	f.	PROPN
bionys-498	222	100	,	,	PUNCT
bionys-498	222	101	cremolini	cremolini	PROPN
bionys-498	222	102	,	,	PUNCT
bionys-498	222	103	c.	c.	PROPN
bionys-498	222	104	,	,	PUNCT
bionys-498	222	105	&	&	CCONJ
bionys-498	222	106	pietrantonio	pietrantonio	PROPN
bionys-498	222	107	,	,	PUNCT
bionys-498	222	108	f.	f.	PROPN
bionys-498	222	109	(	(	PUNCT
bionys-498	222	110	2021	2021	NUM
bionys-498	222	111	)	)	PUNCT
bionys-498	222	112	.	.	PUNCT
bionys-498	223	1	egfr	egfr	ADJ
bionys-498	223	2	amplification	amplification	NOUN
bionys-498	223	3	in	in	ADP
bionys-498	223	4	metastatic	metastatic	ADJ
bionys-498	223	5	colorectal	colorectal	ADJ
bionys-498	223	6	cancer	cancer	NOUN
bionys-498	223	7	.	.	PUNCT
bionys-498	224	1	journal	journal	NOUN
bionys-498	224	2	of	of	ADP
bionys-498	224	3	the	the	DET
bionys-498	224	4	national	national	PROPN
bionys-498	224	5	cancer	cancer	PROPN
bionys-498	224	6	institute	institute	PROPN
bionys-498	224	7	,	,	PUNCT
bionys-498	224	8	113(11	113(11	NUM
bionys-498	224	9	)	)	PUNCT
bionys-498	224	10	,	,	PUNCT
bionys-498	224	11	1561–1569	1561–1569	NUM
bionys-498	224	12	.	.	PUNCT
bionys-498	225	1	ruhe	ruhe	PROPN
bionys-498	225	2	,	,	PUNCT
bionys-498	225	3	j.e	j.e	PROPN
bionys-498	225	4	.	.	PROPN
bionys-498	225	5	,	,	PUNCT
bionys-498	225	6	streit	streit	PROPN
bionys-498	225	7	,	,	PUNCT
bionys-498	225	8	s.	s.	PROPN
bionys-498	225	9	,	,	PUNCT
bionys-498	225	10	hart	hart	PROPN
bionys-498	225	11	,	,	PUNCT
bionys-498	225	12	s.	s.	PROPN
bionys-498	225	13	,	,	PUNCT
bionys-498	225	14	wong	wong	PROPN
bionys-498	225	15	,	,	PUNCT
bionys-498	225	16	c.h	c.h	PROPN
bionys-498	225	17	.	.	PROPN
bionys-498	225	18	,	,	PUNCT
bionys-498	225	19	specht	specht	PROPN
bionys-498	225	20	,	,	PUNCT
bionys-498	225	21	k.	k.	PROPN
bionys-498	225	22	,	,	PUNCT
bionys-498	225	23	knyazev	knyazev	PROPN
bionys-498	225	24	,	,	PUNCT
bionys-498	225	25	p.	p.	PROPN
bionys-498	225	26	,	,	PUNCT
bionys-498	225	27	knyazeva	knyazeva	PROPN
bionys-498	225	28	,	,	PUNCT
bionys-498	225	29	t.	t.	PROPN
bionys-498	225	30	,	,	PUNCT
bionys-498	225	31	tay	tay	PROPN
bionys-498	225	32	,	,	PUNCT
bionys-498	225	33	l.s	l.s	PROPN
bionys-498	225	34	.	.	PROPN
bionys-498	225	35	,	,	PUNCT
bionys-498	225	36	loo	loo	NOUN
bionys-498	225	37	,	,	PUNCT
bionys-498	225	38	h.l	h.l	PROPN
bionys-498	225	39	.	.	PROPN
bionys-498	225	40	,	,	PUNCT
bionys-498	225	41	foo	foo	PROPN
bionys-498	225	42	,	,	PUNCT
bionys-498	226	1	p.	p.	PROPN
bionys-498	226	2	,	,	PUNCT
bionys-498	226	3	wong	wong	PROPN
bionys-498	226	4	,	,	PUNCT
bionys-498	226	5	w.	w.	PROPN
bionys-498	226	6	,	,	PUNCT
bionys-498	226	7	pok	pok	PROPN
bionys-498	226	8	,	,	PUNCT
bionys-498	226	9	s.	s.	PROPN
bionys-498	226	10	,	,	PUNCT
bionys-498	226	11	lim	lim	PROPN
bionys-498	226	12	,	,	PUNCT
bionys-498	226	13	s.j	s.j	PROPN
bionys-498	226	14	.	.	PROPN
bionys-498	226	15	,	,	PUNCT
bionys-498	226	16	ong	ong	PROPN
bionys-498	226	17	,	,	PUNCT
bionys-498	226	18	h.	h.	PROPN
bionys-498	226	19	,	,	PUNCT
bionys-498	226	20	luo	luo	PROPN
bionys-498	226	21	,	,	PUNCT
bionys-498	226	22	m.	m.	NOUN
bionys-498	226	23	,	,	PUNCT
bionys-498	226	24	ho	ho	PROPN
bionys-498	226	25	,	,	PUNCT
bionys-498	226	26	h.k	h.k	PROPN
bionys-498	226	27	.	.	PROPN
bionys-498	226	28	,	,	PUNCT
bionys-498	226	29	peng	peng	PROPN
bionys-498	226	30	,	,	PUNCT
bionys-498	226	31	k.	k.	PROPN
bionys-498	226	32	,	,	PUNCT
bionys-498	226	33	lee	lee	PROPN
bionys-498	226	34	,	,	PUNCT
bionys-498	226	35	t.c	t.c	PROPN
bionys-498	226	36	.	.	PROPN
bionys-498	226	37	,	,	PUNCT
bionys-498	226	38	bezler	bezler	NOUN
bionys-498	226	39	,	,	PUNCT
bionys-498	226	40	m.	m.	NOUN
bionys-498	226	41	,	,	PUNCT
bionys-498	226	42	mann	mann	PROPN
bionys-498	226	43	,	,	PUNCT
bionys-498	226	44	c.	c.	PROPN
bionys-498	226	45	,	,	PUNCT
bionys-498	226	46	gaertner	gaertner	NOUN
bionys-498	226	47	,	,	PUNCT
bionys-498	226	48	s.	s.	PROPN
bionys-498	226	49	,	,	PUNCT
bionys-498	226	50	hoefler	hoefler	PROPN
bionys-498	226	51	,	,	PUNCT
bionys-498	226	52	h.	h.	PROPN
bionys-498	226	53	,	,	PUNCT
bionys-498	226	54	iacobelli	iacobelli	PROPN
bionys-498	226	55	,	,	PUNCT
bionys-498	226	56	s.	s.	PROPN
bionys-498	226	57	,	,	PUNCT
bionys-498	226	58	peter	peter	PROPN
bionys-498	226	59	,	,	PUNCT
bionys-498	226	60	s.	s.	PROPN
bionys-498	226	61	,	,	PUNCT
bionys-498	226	62	tay	tay	PROPN
bionys-498	226	63	,	,	PUNCT
bionys-498	226	64	a.	a.	NOUN
bionys-498	226	65	,	,	PUNCT
bionys-498	226	66	brenner	brenner	PROPN
bionys-498	226	67	,	,	PUNCT
bionys-498	226	68	s.	s.	PROPN
bionys-498	226	69	,	,	PUNCT
bionys-498	226	70	venkatesh	venkatesh	PROPN
bionys-498	226	71	,	,	PUNCT
bionys-498	226	72	b.	b.	PROPN
bionys-498	226	73	,	,	PUNCT
bionys-498	226	74	&	&	CCONJ
bionys-498	226	75	ullrich	ullrich	PROPN
bionys-498	226	76	,	,	PUNCT
bionys-498	226	77	a.	a.	NOUN
bionys-498	226	78	(	(	PUNCT
bionys-498	226	79	2007	2007	NUM
bionys-498	226	80	)	)	PUNCT
bionys-498	226	81	.	.	PUNCT
bionys-498	227	1	genetic	genetic	ADJ
bionys-498	227	2	alterations	alteration	NOUN
bionys-498	227	3	in	in	ADP
bionys-498	227	4	the	the	DET
bionys-498	227	5	tyrosine	tyrosine	NOUN
bionys-498	227	6	kinase	kinase	PROPN
bionys-498	227	7	transcriptome	transcriptome	PROPN
bionys-498	227	8	of	of	ADP
bionys-498	227	9	human	human	ADJ
bionys-498	227	10	cancer	cancer	NOUN
bionys-498	227	11	cell	cell	NOUN
bionys-498	227	12	lines	line	NOUN
bionys-498	227	13	.	.	PUNCT
bionys-498	228	1	cancer	cancer	NOUN
bionys-498	228	2	research	research	NOUN
bionys-498	228	3	,	,	PUNCT
bionys-498	228	4	67(23	67(23	NOUN
bionys-498	228	5	)	)	PUNCT
bionys-498	228	6	,	,	PUNCT
bionys-498	228	7	11368–11376	11368–11376	NUM
bionys-498	228	8	.	.	PUNCT
bionys-498	229	1	saletti	saletti	PROPN
bionys-498	229	2	,	,	PUNCT
bionys-498	229	3	p.	p.	PROPN
bionys-498	229	4	,	,	PUNCT
bionys-498	229	5	molinari	molinari	PROPN
bionys-498	229	6	,	,	PUNCT
bionys-498	229	7	f.	f.	PROPN
bionys-498	229	8	,	,	PUNCT
bionys-498	229	9	de	de	X
bionys-498	229	10	dosso	dosso	PROPN
bionys-498	229	11	,	,	PUNCT
bionys-498	229	12	s.	s.	PROPN
bionys-498	229	13	,	,	PUNCT
bionys-498	229	14	&	&	CCONJ
bionys-498	229	15	frattini	frattini	PROPN
bionys-498	229	16	,	,	PUNCT
bionys-498	229	17	m.	m.	NOUN
bionys-498	229	18	(	(	PUNCT
bionys-498	229	19	2015	2015	NUM
bionys-498	229	20	)	)	PUNCT
bionys-498	229	21	.	.	PUNCT
bionys-498	230	1	egfr	egfr	PROPN
bionys-498	230	2	signaling	signal	VERB
bionys-498	230	3	in	in	ADP
bionys-498	230	4	colorectal	colorectal	ADJ
bionys-498	230	5	cancer	cancer	NOUN
bionys-498	230	6	:	:	PUNCT
bionys-498	230	7	a	a	DET
bionys-498	230	8	clinical	clinical	ADJ
bionys-498	230	9	perspective	perspective	NOUN
bionys-498	230	10	.	.	PUNCT
bionys-498	231	1	gastrointestinal	gastrointestinal	ADJ
bionys-498	231	2	cancer	cancer	NOUN
bionys-498	231	3	:	:	PUNCT
bionys-498	231	4	targets	target	NOUN
bionys-498	231	5	and	and	CCONJ
bionys-498	231	6	therapy	therapy	NOUN
bionys-498	231	7	,	,	PUNCT
bionys-498	231	8	5	5	NUM
bionys-498	231	9	,	,	PUNCT
bionys-498	231	10	21	21	NUM
bionys-498	231	11	-	-	SYM
bionys-498	231	12	38	38	NUM
bionys-498	231	13	.	.	PUNCT
bionys-498	232	1	silva	silva	PROPN
bionys-498	232	2	rocha	rocha	PROPN
bionys-498	232	3	,	,	PUNCT
bionys-498	232	4	f.	f.	PROPN
bionys-498	232	5	,	,	PUNCT
bionys-498	232	6	da	da	PROPN
bionys-498	232	7	silva	silva	PROPN
bionys-498	232	8	maués	maués	PROPN
bionys-498	232	9	,	,	PUNCT
bionys-498	232	10	j.h	j.h	PROPN
bionys-498	232	11	.	.	PROPN
bionys-498	232	12	,	,	PUNCT
bionys-498	232	13	brito	brito	PROPN
bionys-498	232	14	lins	lins	PROPN
bionys-498	232	15	pereira	pereira	PROPN
bionys-498	232	16	,	,	PUNCT
bionys-498	232	17	c.m	c.m	PROPN
bionys-498	232	18	.	.	PROPN
bionys-498	232	19	,	,	PUNCT
bionys-498	232	20	moreira	moreira	PROPN
bionys-498	232	21	-	-	PUNCT
bionys-498	232	22	nunes	nunes	PROPN
bionys-498	232	23	,	,	PUNCT
bionys-498	232	24	c.a	c.a	PROPN
bionys-498	232	25	.	.	PROPN
bionys-498	232	26	,	,	PUNCT
bionys-498	232	27	&	&	CCONJ
bionys-498	232	28	rodriguez	rodriguez	PROPN
bionys-498	232	29	burbano	burbano	PROPN
bionys-498	232	30	,	,	PUNCT
bionys-498	232	31	r.m	r.m	PROPN
bionys-498	232	32	.	.	PROPN
bionys-498	232	33	(	(	PUNCT
bionys-498	232	34	2021	2021	NUM
bionys-498	232	35	)	)	PUNCT
bionys-498	232	36	.	.	PUNCT
bionys-498	233	1	analysis	analysis	NOUN
bionys-498	233	2	of	of	ADP
bionys-498	233	3	increased	increase	VERB
bionys-498	233	4	egfr	egfr	NOUN
bionys-498	233	5	and	and	CCONJ
bionys-498	233	6	igf-1r	igf-1r	ADJ
bionys-498	233	7	signaling	signal	VERB
bionys-498	233	8	and	and	CCONJ
bionys-498	233	9	its	its	PRON
bionys-498	233	10	correlation	correlation	NOUN
bionys-498	233	11	with	with	ADP
bionys-498	233	12	socio	socio	NOUN
bionys-498	233	13	-	-	PUNCT
bionys-498	233	14	epidemiological	epidemiological	ADJ
bionys-498	233	15	features	feature	NOUN
bionys-498	233	16	and	and	CCONJ
bionys-498	233	17	biological	biological	ADJ
bionys-498	233	18	profile	profile	NOUN
bionys-498	233	19	in	in	ADP
bionys-498	233	20	breast	breast	NOUN
bionys-498	233	21	cancer	cancer	NOUN
bionys-498	233	22	patients	patient	NOUN
bionys-498	233	23	:	:	PUNCT
bionys-498	233	24	a	a	DET
bionys-498	233	25	45	45	NUM
bionys-498	233	26	jugović	jugović	NOUN
bionys-498	233	27	et	et	PROPN
bionys-498	233	28	al	al	PROPN
bionys-498	233	29	.	.	PUNCT
bionys-498	234	1	●	●	PUNCT
bionys-498	234	2	the	the	DET
bionys-498	234	3	frequency	frequency	NOUN
bionys-498	234	4	and	and	CCONJ
bionys-498	234	5	type	type	NOUN
bionys-498	234	6	of	of	ADP
bionys-498	234	7	mutations	mutation	NOUN
bionys-498	234	8	in	in	ADP
bionys-498	234	9	the	the	DET
bionys-498	234	10	egfr	egfr	ADJ
bionys-498	234	11	gene	gene	NOUN
bionys-498	234	12	of	of	ADP
bionys-498	234	13	colorectal	colorectal	ADJ
bionys-498	234	14	carcinoma	carcinoma	NOUN
bionys-498	234	15	patients	patient	NOUN
bionys-498	234	16	in	in	ADP
bionys-498	234	17	southeastern	southeastern	ADJ
bionys-498	234	18	serbia	serbia	PROPN
bionys-498	234	19	46	46	NUM
bionys-498	234	20	study	study	NOUN
bionys-498	234	21	in	in	ADP
bionys-498	234	22	northern	northern	ADJ
bionys-498	234	23	brazil	brazil	PROPN
bionys-498	234	24	.	.	PUNCT
bionys-498	235	1	breast	breast	NOUN
bionys-498	235	2	cancer	cancer	NOUN
bionys-498	235	3	(	(	PUNCT
bionys-498	235	4	dove	dove	VERB
bionys-498	235	5	med	med	ADJ
bionys-498	235	6	press	press	NOUN
bionys-498	235	7	)	)	PUNCT
bionys-498	235	8	,	,	PUNCT
bionys-498	235	9	13	13	NUM
bionys-498	235	10	,	,	PUNCT
bionys-498	235	11	325	325	NUM
bionys-498	235	12	-	-	SYM
bionys-498	235	13	339	339	NUM
bionys-498	235	14	.	.	PUNCT
bionys-498	236	1	skřičková	skřičková	PROPN
bionys-498	236	2	,	,	PUNCT
bionys-498	236	3	j.	j.	PROPN
bionys-498	236	4	,	,	PUNCT
bionys-498	236	5	májková	májková	PROPN
bionys-498	236	6	,	,	PUNCT
bionys-498	236	7	p.	p.	PROPN
bionys-498	236	8	,	,	PUNCT
bionys-498	236	9	barinová	barinová	PROPN
bionys-498	236	10	,	,	PUNCT
bionys-498	236	11	m.	m.	NOUN
bionys-498	236	12	,	,	PUNCT
bionys-498	236	13	bratová	bratová	NOUN
bionys-498	236	14	,	,	PUNCT
bionys-498	236	15	m.	m.	NOUN
bionys-498	236	16	,	,	PUNCT
bionys-498	236	17	pešek	pešek	NOUN
bionys-498	236	18	,	,	PUNCT
bionys-498	236	19	m.	m.	NOUN
bionys-498	236	20	,	,	PUNCT
bionys-498	236	21	svaton	svaton	NOUN
bionys-498	236	22	,	,	PUNCT
bionys-498	236	23	m.	m.	NOUN
bionys-498	236	24	,	,	PUNCT
bionys-498	236	25	kolek	kolek	VERB
bionys-498	236	26	,	,	PUNCT
bionys-498	236	27	v.	v.	PROPN
bionys-498	236	28	,	,	PUNCT
bionys-498	236	29	fišer	fišer	PROPN
bionys-498	236	30	,	,	PUNCT
bionys-498	236	31	o.	o.	PROPN
bionys-498	236	32	,	,	PUNCT
bionys-498	236	33	koubková	koubková	PROPN
bionys-498	236	34	,	,	PUNCT
bionys-498	236	35	l.	l.	PROPN
bionys-498	236	36	,	,	PUNCT
bionys-498	236	37	benejová	benejová	PROPN
bionys-498	236	38	,	,	PUNCT
bionys-498	236	39	a.	a.	NOUN
bionys-498	236	40	,	,	PUNCT
bionys-498	236	41	venclícek	venclícek	ADJ
bionys-498	236	42	,	,	PUNCT
bionys-498	236	43	o.	o.	PROPN
bionys-498	236	44	,	,	PUNCT
bionys-498	236	45	cernovská	cernovská	PROPN
bionys-498	236	46	,	,	PUNCT
bionys-498	236	47	m.	m.	NOUN
bionys-498	236	48	,	,	PUNCT
bionys-498	236	49	havel	havel	PROPN
bionys-498	236	50	,	,	PUNCT
bionys-498	236	51	l.	l.	PROPN
bionys-498	236	52	,	,	PUNCT
bionys-498	236	53	hrnciarik	hrnciarik	PROPN
bionys-498	236	54	,	,	PUNCT
bionys-498	236	55	m.	m.	NOUN
bionys-498	236	56	,	,	PUNCT
bionys-498	236	57	roubec	roubec	PROPN
bionys-498	236	58	,	,	PUNCT
bionys-498	236	59	j.	j.	PROPN
bionys-498	236	60	,	,	PUNCT
bionys-498	236	61	milada	milada	PROPN
bionys-498	236	62	,	,	PUNCT
bionys-498	236	63	z.	z.	PROPN
bionys-498	236	64	,	,	PUNCT
bionys-498	236	65	opálka	opálka	NOUN
bionys-498	236	66	,	,	PUNCT
bionys-498	236	67	p.	p.	PROPN
bionys-498	236	68	,	,	PUNCT
bionys-498	236	69	krejcí	krejcí	PROPN
bionys-498	236	70	,	,	PUNCT
bionys-498	236	71	j.	j.	PROPN
bionys-498	236	72	,	,	PUNCT
bionys-498	236	73	krejcí	krejcí	PROPN
bionys-498	236	74	,	,	PUNCT
bionys-498	236	75	d.	d.	PROPN
bionys-498	236	76	,	,	PUNCT
bionys-498	236	77	coupková	coupková	PROPN
bionys-498	236	78	,	,	PUNCT
bionys-498	236	79	h.	h.	PROPN
bionys-498	236	80	,	,	PUNCT
bionys-498	236	81	&	&	CCONJ
bionys-498	236	82	merta	merta	PROPN
bionys-498	236	83	,	,	PUNCT
bionys-498	236	84	z.	z.	PROPN
bionys-498	236	85	(	(	PUNCT
bionys-498	236	86	2020	2020	NUM
bionys-498	236	87	)	)	PUNCT
bionys-498	236	88	.	.	PUNCT
bionys-498	237	1	epidermal	epidermal	ADJ
bionys-498	237	2	growth	growth	NOUN
bionys-498	237	3	factor	factor	NOUN
bionys-498	237	4	receptor	receptor	NOUN
bionys-498	237	5	(	(	PUNCT
bionys-498	237	6	egfr	egfr	X
bionys-498	237	7	)	)	PUNCT
bionys-498	237	8	gene	gene	NOUN
bionys-498	237	9	mutation	mutation	NOUN
bionys-498	237	10	testing	testing	NOUN
bionys-498	237	11	prior	prior	ADV
bionys-498	237	12	to	to	ADP
bionys-498	237	13	tyrosine	tyrosine	PROPN
bionys-498	237	14	kinase	kinase	PROPN
bionys-498	237	15	inhibitors	inhibitor	NOUN
bionys-498	237	16	(	(	PUNCT
bionys-498	237	17	tki	tki	NOUN
bionys-498	237	18	)	)	PUNCT
bionys-498	237	19	treatment	treatment	NOUN
bionys-498	237	20	–	–	PUNCT
bionys-498	237	21	prospective	prospective	ADJ
bionys-498	237	22	data	datum	NOUN
bionys-498	237	23	from	from	ADP
bionys-498	237	24	the	the	DET
bionys-498	237	25	czech	czech	PROPN
bionys-498	237	26	tulung	tulung	PROPN
bionys-498	237	27	registry	registry	NOUN
bionys-498	237	28	.	.	PUNCT
bionys-498	238	1	european	european	ADJ
bionys-498	238	2	respiratory	respiratory	ADJ
bionys-498	238	3	journal	journal	NOUN
bionys-498	238	4	,	,	PUNCT
bionys-498	238	5	56(64	56(64	PROPN
bionys-498	238	6	)	)	PUNCT
bionys-498	238	7	,	,	PUNCT
bionys-498	238	8	1686	1686	NUM
bionys-498	238	9	.	.	PUNCT
bionys-498	239	1	syrigos	syrigo	NOUN
bionys-498	239	2	,	,	PUNCT
bionys-498	239	3	k.	k.	PROPN
bionys-498	239	4	,	,	PUNCT
bionys-498	239	5	kotteas	kotteas	PROPN
bionys-498	239	6	,	,	PUNCT
bionys-498	239	7	i.	i.	PROPN
bionys-498	239	8	,	,	PUNCT
bionys-498	239	9	paraskeva	paraskeva	NOUN
bionys-498	239	10	,	,	PUNCT
bionys-498	239	11	m.	m.	NOUN
bionys-498	239	12	,	,	PUNCT
bionys-498	239	13	gkiozos	gkiozos	PROPN
bionys-498	239	14	,	,	PUNCT
bionys-498	239	15	i.	i.	NOUN
bionys-498	239	16	,	,	PUNCT
bionys-498	239	17	boura	boura	NOUN
bionys-498	239	18	,	,	PUNCT
bionys-498	239	19	p.	p.	NOUN
bionys-498	239	20	,	,	PUNCT
bionys-498	239	21	tsagouli	tsagouli	PROPN
bionys-498	239	22	,	,	PUNCT
bionys-498	239	23	s.	s.	PROPN
bionys-498	239	24	,	,	PUNCT
bionys-498	239	25	grapsa	grapsa	VERB
bionys-498	239	26	,	,	PUNCT
bionys-498	239	27	d.	d.	PROPN
bionys-498	239	28	,	,	PUNCT
bionys-498	239	29	&	&	CCONJ
bionys-498	239	30	charpidou	charpidou	NOUN
bionys-498	239	31	,	,	PUNCT
bionys-498	239	32	a.	a.	NOUN
bionys-498	239	33	(	(	PUNCT
bionys-498	239	34	2018	2018	NUM
bionys-498	239	35	)	)	PUNCT
bionys-498	239	36	.	.	PUNCT
bionys-498	240	1	prognostic	prognostic	ADJ
bionys-498	240	2	value	value	NOUN
bionys-498	240	3	of	of	ADP
bionys-498	240	4	egfr	egfr	ADJ
bionys-498	240	5	genotype	genotype	NOUN
bionys-498	240	6	in	in	ADP
bionys-498	240	7	egfr	egfr	ADJ
bionys-498	240	8	-	-	PUNCT
bionys-498	240	9	mutant	mutant	ADJ
bionys-498	240	10	non	non	ADJ
bionys-498	240	11	-	-	ADJ
bionys-498	240	12	small	small	ADJ
bionys-498	240	13	cell	cell	NOUN
bionys-498	240	14	lung	lung	NOUN
bionys-498	240	15	cancer	cancer	NOUN
bionys-498	240	16	.	.	PUNCT
bionys-498	241	1	european	european	ADJ
bionys-498	241	2	respiratory	respiratory	ADJ
bionys-498	241	3	journal	journal	NOUN
bionys-498	241	4	,	,	PUNCT
bionys-498	241	5	52	52	NUM
bionys-498	241	6	,	,	PUNCT
bionys-498	241	7	pa	pa	PROPN
bionys-498	241	8	2852	2852	NUM
bionys-498	241	9	.	.	PUNCT
bionys-498	242	1	tanaka	tanaka	PROPN
bionys-498	242	2	,	,	PUNCT
bionys-498	242	3	t.	t.	PROPN
bionys-498	242	4	,	,	PUNCT
bionys-498	242	5	kaida	kaida	PROPN
bionys-498	242	6	,	,	PUNCT
bionys-498	242	7	t.	t.	PROPN
bionys-498	242	8	,	,	PUNCT
bionys-498	242	9	yokoi	yokoi	PROPN
bionys-498	242	10	,	,	PUNCT
bionys-498	242	11	k.	k.	PROPN
bionys-498	242	12	,	,	PUNCT
bionys-498	242	13	ishii	ishii	PROPN
bionys-498	242	14	,	,	PUNCT
bionys-498	242	15	s.	s.	PROPN
bionys-498	242	16	,	,	PUNCT
bionys-498	242	17	nishizawa	nishizawa	PROPN
bionys-498	242	18	,	,	PUNCT
bionys-498	242	19	n.	n.	NOUN
bionys-498	242	20	,	,	PUNCT
bionys-498	242	21	kawamata	kawamata	PROPN
bionys-498	242	22	,	,	PUNCT
bionys-498	242	23	h.	h.	PROPN
bionys-498	242	24	,	,	PUNCT
bionys-498	242	25	katoh	katoh	PROPN
bionys-498	242	26	,	,	PUNCT
bionys-498	242	27	h.	h.	PROPN
bionys-498	242	28	,	,	PUNCT
bionys-498	242	29	sato	sato	PROPN
bionys-498	242	30	,	,	PUNCT
bionys-498	242	31	t.	t.	PROPN
bionys-498	242	32	,	,	PUNCT
bionys-498	242	33	nakamura	nakamura	NOUN
bionys-498	242	34	,	,	PUNCT
bionys-498	242	35	t.	t.	PROPN
bionys-498	242	36	,	,	PUNCT
bionys-498	242	37	watanabe	watanabe	PROPN
bionys-498	242	38	,	,	PUNCT
bionys-498	242	39	m.	m.	NOUN
bionys-498	242	40	,	,	PUNCT
bionys-498	242	41	&	&	CCONJ
bionys-498	242	42	yamashita	yamashita	PROPN
bionys-498	242	43	,	,	PUNCT
bionys-498	242	44	k.	k.	PROPN
bionys-498	242	45	(	(	PUNCT
bionys-498	242	46	2019	2019	NUM
bionys-498	242	47	)	)	PUNCT
bionys-498	242	48	.	.	PUNCT
bionys-498	243	1	critical	critical	ADJ
bionys-498	243	2	relevance	relevance	NOUN
bionys-498	243	3	of	of	ADP
bionys-498	243	4	genomic	genomic	ADJ
bionys-498	243	5	gains	gain	NOUN
bionys-498	243	6	of	of	ADP
bionys-498	243	7	prl3	prl3	NOUN
bionys-498	243	8	/	/	SYM
bionys-498	243	9	egfr	egfr	X
bionys-498	243	10	/	/	SYM
bionys-498	243	11	c	c	NOUN
bionys-498	243	12	-	-	PUNCT
bionys-498	243	13	myc	myc	NOUN
bionys-498	243	14	pathway	pathway	NOUN
bionys-498	243	15	genes	gene	NOUN
bionys-498	243	16	in	in	ADP
bionys-498	243	17	liver	liver	NOUN
bionys-498	243	18	metastasis	metastasis	NOUN
bionys-498	243	19	of	of	ADP
bionys-498	243	20	colorectal	colorectal	ADJ
bionys-498	243	21	cancer	cancer	NOUN
bionys-498	243	22	.	.	PUNCT
bionys-498	244	1	oncology	oncology	NOUN
bionys-498	244	2	letters	letter	NOUN
bionys-498	244	3	,	,	PUNCT
bionys-498	244	4	17(1	17(1	NUM
bionys-498	244	5	)	)	PUNCT
bionys-498	244	6	,	,	PUNCT
bionys-498	244	7	1257	1257	NUM
bionys-498	244	8	–	–	PUNCT
bionys-498	244	9	1266	1266	NUM
bionys-498	244	10	.	.	PUNCT
bionys-498	245	1	tasdemir	tasdemir	PROPN
bionys-498	245	2	,	,	PUNCT
bionys-498	245	3	s.	s.	PROPN
bionys-498	245	4	,	,	PUNCT
bionys-498	245	5	taheri	taheri	NOUN
bionys-498	245	6	,	,	PUNCT
bionys-498	245	7	s.	s.	PROPN
bionys-498	245	8	,	,	PUNCT
bionys-498	245	9	akalin	akalin	PROPN
bionys-498	245	10	,	,	PUNCT
bionys-498	245	11	h.	h.	PROPN
bionys-498	245	12	,	,	PUNCT
bionys-498	245	13	kontas	konta	NOUN
bionys-498	245	14	,	,	PUNCT
bionys-498	245	15	o.	o.	NOUN
bionys-498	245	16	,	,	PUNCT
bionys-498	245	17	onal	onal	ADJ
bionys-498	245	18	,	,	PUNCT
bionys-498	245	19	o.	o.	PROPN
bionys-498	245	20	,	,	PUNCT
bionys-498	245	21	&	&	CCONJ
bionys-498	245	22	ozkul	ozkul	ADJ
bionys-498	245	23	,	,	PUNCT
bionys-498	245	24	y.	y.	PROPN
bionys-498	245	25	(	(	PUNCT
bionys-498	245	26	2019	2019	NUM
bionys-498	245	27	)	)	PUNCT
bionys-498	245	28	.	.	PUNCT
bionys-498	246	1	increased	increase	VERB
bionys-498	246	2	egfr	egfr	ADJ
bionys-498	246	3	mrna	mrna	PROPN
bionys-498	246	4	expression	expression	NOUN
bionys-498	246	5	levels	level	NOUN
bionys-498	246	6	in	in	ADP
bionys-498	246	7	non	non	ADJ
bionys-498	246	8	-	-	ADJ
bionys-498	246	9	small	small	ADJ
bionys-498	246	10	cell	cell	NOUN
bionys-498	246	11	lung	lung	NOUN
bionys-498	246	12	cancer	cancer	NOUN
bionys-498	246	13	.	.	PUNCT
bionys-498	247	1	the	the	DET
bionys-498	247	2	eurasian	eurasian	ADJ
bionys-498	247	3	journal	journal	NOUN
bionys-498	247	4	of	of	ADP
bionys-498	247	5	medicine	medicine	NOUN
bionys-498	247	6	,	,	PUNCT
bionys-498	247	7	51(2	51(2	NUM
bionys-498	247	8	)	)	PUNCT
bionys-498	247	9	,	,	PUNCT
bionys-498	247	10	177–185	177–185	NUM
bionys-498	247	11	.	.	PUNCT
bionys-498	248	1	biologica	biologica	PROPN
bionys-498	248	2	nyssana	nyssana	PROPN
bionys-498	248	3	●	●	PUNCT
bionys-498	248	4	14	14	NUM
bionys-498	248	5	(	(	PUNCT
bionys-498	248	6	1	1	NUM
bionys-498	248	7	)	)	PUNCT
bionys-498	248	8	june	june	PROPN
bionys-498	248	9	2023	2023	NUM
bionys-498	248	10	:	:	PUNCT
bionys-498	248	11	39	39	NUM
bionys-498	248	12	-	-	SYM
bionys-498	248	13	46	46	NUM
bionys-498	248	14	tong	tong	PROPN
bionys-498	248	15	,	,	PUNCT
bionys-498	248	16	g.j	g.j	PROPN
bionys-498	248	17	.	.	PROPN
bionys-498	248	18	,	,	PUNCT
bionys-498	248	19	zhang	zhang	PROPN
bionys-498	248	20	,	,	PUNCT
bionys-498	248	21	g.y	g.y	PROPN
bionys-498	248	22	.	.	PROPN
bionys-498	248	23	,	,	PUNCT
bionys-498	248	24	liu	liu	PROPN
bionys-498	248	25	,	,	PUNCT
bionys-498	248	26	j.	j.	PROPN
bionys-498	248	27	,	,	PUNCT
bionys-498	248	28	zheng	zheng	PROPN
bionys-498	248	29	,	,	PUNCT
bionys-498	248	30	z.z	z.z	PROPN
bionys-498	248	31	.	.	PROPN
bionys-498	248	32	,	,	PUNCT
bionys-498	248	33	chen	chen	PROPN
bionys-498	248	34	,	,	PUNCT
bionys-498	248	35	y.	y.	PROPN
bionys-498	248	36	,	,	PUNCT
bionys-498	248	37	niu	niu	PROPN
bionys-498	248	38	,	,	PUNCT
bionys-498	248	39	p.p	p.p	PROPN
bionys-498	248	40	.	.	PROPN
bionys-498	248	41	,	,	PUNCT
bionys-498	248	42	&	&	CCONJ
bionys-498	248	43	xu	xu	PROPN
bionys-498	248	44	,	,	PUNCT
bionys-498	248	45	x.t	x.t	PROPN
bionys-498	248	46	.	.	PROPN
bionys-498	248	47	(	(	PUNCT
bionys-498	248	48	2018	2018	NUM
bionys-498	248	49	)	)	PUNCT
bionys-498	248	50	.	.	PUNCT
bionys-498	249	1	comparison	comparison	NOUN
bionys-498	249	2	of	of	ADP
bionys-498	249	3	the	the	DET
bionys-498	249	4	eighth	eighth	ADJ
bionys-498	249	5	version	version	NOUN
bionys-498	249	6	of	of	ADP
bionys-498	249	7	the	the	DET
bionys-498	249	8	american	american	PROPN
bionys-498	249	9	joint	joint	PROPN
bionys-498	249	10	committee	committee	PROPN
bionys-498	249	11	on	on	ADP
bionys-498	249	12	cancer	cancer	NOUN
bionys-498	249	13	manual	manual	NOUN
bionys-498	249	14	to	to	ADP
bionys-498	249	15	the	the	DET
bionys-498	249	16	seventh	seventh	ADJ
bionys-498	249	17	version	version	NOUN
bionys-498	249	18	for	for	ADP
bionys-498	249	19	colorectal	colorectal	ADJ
bionys-498	249	20	cancer	cancer	NOUN
bionys-498	249	21	:	:	PUNCT
bionys-498	249	22	a	a	DET
bionys-498	249	23	retrospective	retrospective	ADJ
bionys-498	249	24	review	review	NOUN
bionys-498	249	25	of	of	ADP
bionys-498	249	26	our	our	PRON
bionys-498	249	27	data	datum	NOUN
bionys-498	249	28	.	.	PUNCT
bionys-498	250	1	world	world	PROPN
bionys-498	250	2	journal	journal	PROPN
bionys-498	250	3	of	of	ADP
bionys-498	250	4	clinical	clinical	ADJ
bionys-498	250	5	oncology	oncology	NOUN
bionys-498	250	6	,	,	PUNCT
bionys-498	250	7	9(7	9(7	NUM
bionys-498	250	8	)	)	PUNCT
bionys-498	250	9	,	,	PUNCT
bionys-498	250	10	148–161	148–161	NUM
bionys-498	250	11	.	.	PUNCT
bionys-498	251	1	uhlyarik	uhlyarik	ADJ
bionys-498	251	2	,	,	PUNCT
bionys-498	251	3	a.	a.	NOUN
bionys-498	251	4	,	,	PUNCT
bionys-498	251	5	piurko	piurko	PROPN
bionys-498	251	6	,	,	PUNCT
bionys-498	251	7	v.	v.	ADP
bionys-498	251	8	,	,	PUNCT
bionys-498	251	9	papai	papai	NOUN
bionys-498	251	10	,	,	PUNCT
bionys-498	251	11	z.	z.	PROPN
bionys-498	251	12	,	,	PUNCT
bionys-498	251	13	raso	raso	NOUN
bionys-498	251	14	,	,	PUNCT
bionys-498	251	15	e.	e.	PROPN
bionys-498	251	16	,	,	PUNCT
bionys-498	251	17	lahm	lahm	PROPN
bionys-498	251	18	,	,	PUNCT
bionys-498	251	19	e.	e.	PROPN
bionys-498	251	20	,	,	PUNCT
bionys-498	251	21	kiss	kiss	PROPN
bionys-498	251	22	,	,	PUNCT
bionys-498	251	23	e.	e.	PROPN
bionys-498	251	24	,	,	PUNCT
bionys-498	251	25	sikter	sikter	PROPN
bionys-498	251	26	,	,	PUNCT
bionys-498	251	27	m.	m.	NOUN
bionys-498	251	28	,	,	PUNCT
bionys-498	251	29	vachaja	vachaja	PROPN
bionys-498	251	30	,	,	PUNCT
bionys-498	251	31	j.	j.	PROPN
bionys-498	251	32	,	,	PUNCT
bionys-498	251	33	kenessey	kenessey	PROPN
bionys-498	251	34	,	,	PUNCT
bionys-498	251	35	i.	i.	PROPN
bionys-498	251	36	,	,	PUNCT
bionys-498	251	37	&	&	CCONJ
bionys-498	251	38	timar	timar	PROPN
bionys-498	251	39	,	,	PUNCT
bionys-498	251	40	j.	j.	PROPN
bionys-498	251	41	(	(	PUNCT
bionys-498	251	42	2020	2020	NUM
bionys-498	251	43	)	)	PUNCT
bionys-498	251	44	.	.	PUNCT
bionys-498	252	1	egfr	egfr	ADJ
bionys-498	252	2	protein	protein	NOUN
bionys-498	252	3	expression	expression	NOUN
bionys-498	252	4	in	in	ADP
bionys-498	252	5	kras	kras	PROPN
bionys-498	252	6	wild	wild	ADJ
bionys-498	252	7	-	-	PUNCT
bionys-498	252	8	type	type	NOUN
bionys-498	252	9	metastatic	metastatic	ADJ
bionys-498	252	10	colorectal	colorectal	ADJ
bionys-498	252	11	cancer	cancer	NOUN
bionys-498	252	12	is	be	AUX
bionys-498	252	13	another	another	DET
bionys-498	252	14	negative	negative	ADJ
bionys-498	252	15	predictive	predictive	ADJ
bionys-498	252	16	factor	factor	NOUN
bionys-498	252	17	of	of	ADP
bionys-498	252	18	the	the	DET
bionys-498	252	19	cetuximab	cetuximab	NOUN
bionys-498	252	20	therapy	therapy	NOUN
bionys-498	252	21	.	.	PUNCT
bionys-498	253	1	cancers	cancer	NOUN
bionys-498	253	2	,	,	PUNCT
bionys-498	253	3	12(3	12(3	NUM
bionys-498	253	4	)	)	PUNCT
bionys-498	253	5	,	,	PUNCT
bionys-498	253	6	614	614	NUM
bionys-498	253	7	.	.	PUNCT
bionys-498	254	1	wang	wang	PROPN
bionys-498	254	2	,	,	PUNCT
bionys-498	254	3	d.	d.	PROPN
bionys-498	254	4	,	,	PUNCT
bionys-498	254	5	wang	wang	PROPN
bionys-498	254	6	,	,	PUNCT
bionys-498	254	7	b.	b.	PROPN
bionys-498	254	8	,	,	PUNCT
bionys-498	254	9	wang	wang	PROPN
bionys-498	254	10	,	,	PUNCT
bionys-498	254	11	r.	r.	PROPN
bionys-498	254	12	,	,	PUNCT
bionys-498	254	13	zhang	zhang	PROPN
bionys-498	254	14	,	,	PUNCT
bionys-498	254	15	z.	z.	PROPN
bionys-498	254	16	,	,	PUNCT
bionys-498	254	17	lin	lin	PROPN
bionys-498	254	18	,	,	PUNCT
bionys-498	254	19	y.	y.	PROPN
bionys-498	254	20	,	,	PUNCT
bionys-498	254	21	huang	huang	PROPN
bionys-498	254	22	,	,	PUNCT
bionys-498	254	23	g.	g.	PROPN
bionys-498	254	24	,	,	PUNCT
bionys-498	254	25	lin	lin	PROPN
bionys-498	254	26	,	,	PUNCT
bionys-498	254	27	s.	s.	PROPN
bionys-498	254	28	,	,	PUNCT
bionys-498	254	29	jiang	jiang	PROPN
bionys-498	254	30	,	,	PUNCT
bionys-498	254	31	y.	y.	PROPN
bionys-498	254	32	,	,	PUNCT
bionys-498	254	33	wang	wang	PROPN
bionys-498	254	34	,	,	PUNCT
bionys-498	254	35	w.	w.	PROPN
bionys-498	254	36	,	,	PUNCT
bionys-498	254	37	wang	wang	PROPN
bionys-498	254	38	,	,	PUNCT
bionys-498	254	39	l.	l.	PROPN
bionys-498	254	40	,	,	PUNCT
bionys-498	254	41	&	&	CCONJ
bionys-498	254	42	huang	huang	PROPN
bionys-498	254	43	,	,	PUNCT
bionys-498	254	44	q.	q.	PROPN
bionys-498	254	45	(	(	PUNCT
bionys-498	254	46	2017	2017	NUM
bionys-498	254	47	)	)	PUNCT
bionys-498	254	48	.	.	PUNCT
bionys-498	255	1	high	high	ADJ
bionys-498	255	2	expression	expression	NOUN
bionys-498	255	3	of	of	ADP
bionys-498	255	4	egfr	egfr	NOUN
bionys-498	255	5	predicts	predict	VERB
bionys-498	255	6	poor	poor	ADJ
bionys-498	255	7	survival	survival	NOUN
bionys-498	255	8	in	in	ADP
bionys-498	255	9	patients	patient	NOUN
bionys-498	255	10	with	with	ADP
bionys-498	255	11	resected	resect	VERB
bionys-498	255	12	t3	t3	NOUN
bionys-498	255	13	stage	stage	NOUN
bionys-498	255	14	gastric	gastric	ADJ
bionys-498	255	15	adenocarcinoma	adenocarcinoma	NOUN
bionys-498	255	16	and	and	CCONJ
bionys-498	255	17	promotes	promote	VERB
bionys-498	255	18	cancer	cancer	NOUN
bionys-498	255	19	cell	cell	NOUN
bionys-498	255	20	survival	survival	NOUN
bionys-498	255	21	.	.	PUNCT
bionys-498	256	1	oncology	oncology	NOUN
bionys-498	256	2	letters	letter	NOUN
bionys-498	256	3	,	,	PUNCT
bionys-498	256	4	13(5	13(5	NUM
bionys-498	256	5	)	)	PUNCT
bionys-498	256	6	,	,	PUNCT
bionys-498	256	7	3003	3003	NUM
bionys-498	256	8	-	-	SYM
bionys-498	256	9	3013	3013	NUM
bionys-498	256	10	.	.	PUNCT
bionys-498	257	1	wee	wee	PROPN
bionys-498	257	2	,	,	PUNCT
bionys-498	257	3	p.	p.	PROPN
bionys-498	257	4	&	&	CCONJ
bionys-498	257	5	wang	wang	PROPN
bionys-498	257	6	,	,	PUNCT
bionys-498	257	7	z.	z.	PROPN
bionys-498	257	8	(	(	PUNCT
bionys-498	257	9	2017	2017	NUM
bionys-498	257	10	)	)	PUNCT
bionys-498	257	11	.	.	PUNCT
bionys-498	258	1	epidermal	epidermal	ADJ
bionys-498	258	2	growth	growth	NOUN
bionys-498	258	3	factor	factor	NOUN
bionys-498	258	4	receptor	receptor	NOUN
bionys-498	258	5	cell	cell	NOUN
bionys-498	258	6	proliferation	proliferation	NOUN
bionys-498	258	7	signaling	signal	VERB
bionys-498	258	8	pathways	pathway	NOUN
bionys-498	258	9	.	.	PUNCT
bionys-498	259	1	cancers	cancer	NOUN
bionys-498	259	2	,	,	PUNCT
bionys-498	259	3	9(5	9(5	NUM
bionys-498	259	4	)	)	PUNCT
bionys-498	259	5	,	,	PUNCT
bionys-498	259	6	52	52	NUM
bionys-498	259	7	.	.	PUNCT
bionys-498	260	1	zou	zou	PROPN
bionys-498	260	2	,	,	PUNCT
bionys-498	260	3	s.m	s.m	PROPN
bionys-498	260	4	.	.	PROPN
bionys-498	260	5	,	,	PUNCT
bionys-498	260	6	li	li	PROPN
bionys-498	260	7	,	,	PUNCT
bionys-498	260	8	w.h	w.h	PROPN
bionys-498	260	9	.	.	PROPN
bionys-498	260	10	,	,	PUNCT
bionys-498	260	11	wang	wang	PROPN
bionys-498	260	12	,	,	PUNCT
bionys-498	260	13	w.m	w.m	PROPN
bionys-498	260	14	.	.	PROPN
bionys-498	260	15	,	,	PUNCT
bionys-498	260	16	li	li	PROPN
bionys-498	260	17	,	,	PUNCT
bionys-498	260	18	w.b	w.b	PROPN
bionys-498	260	19	.	.	PROPN
bionys-498	260	20	,	,	PUNCT
bionys-498	260	21	shi	shi	PROPN
bionys-498	260	22	,	,	PUNCT
bionys-498	260	23	s.s	s.s	PROPN
bionys-498	260	24	.	.	PROPN
bionys-498	260	25	,	,	PUNCT
bionys-498	260	26	ying	ying	PROPN
bionys-498	260	27	,	,	PUNCT
bionys-498	260	28	j.m	j.m	PROPN
bionys-498	260	29	.	.	PROPN
bionys-498	260	30	,	,	PUNCT
bionys-498	260	31	&	&	CCONJ
bionys-498	260	32	lyu	lyu	PROPN
bionys-498	260	33	,	,	PUNCT
bionys-498	260	34	n.	n.	NOUN
bionys-498	260	35	(	(	PUNCT
bionys-498	260	36	2018	2018	NUM
bionys-498	260	37	)	)	PUNCT
bionys-498	260	38	.	.	PUNCT
bionys-498	261	1	the	the	DET
bionys-498	261	2	gene	gene	NOUN
bionys-498	261	3	mutational	mutational	ADJ
bionys-498	261	4	discrepancies	discrepancy	NOUN
bionys-498	261	5	between	between	ADP
bionys-498	261	6	primary	primary	ADJ
bionys-498	261	7	and	and	CCONJ
bionys-498	261	8	paired	pair	VERB
bionys-498	261	9	metastatic	metastatic	ADJ
bionys-498	261	10	colorectal	colorectal	ADJ
bionys-498	261	11	carcinoma	carcinoma	NOUN
bionys-498	261	12	detected	detect	VERB
bionys-498	261	13	by	by	ADP
bionys-498	261	14	next	next	ADJ
bionys-498	261	15	-	-	PUNCT
bionys-498	261	16	generation	generation	NOUN
bionys-498	261	17	sequencing	sequencing	NOUN
bionys-498	261	18	.	.	PUNCT
bionys-498	262	1	journal	journal	NOUN
bionys-498	262	2	of	of	ADP
bionys-498	262	3	cancer	cancer	NOUN
bionys-498	262	4	research	research	NOUN
bionys-498	262	5	and	and	CCONJ
bionys-498	262	6	clinical	clinical	ADJ
bionys-498	262	7	oncology	oncology	NOUN
bionys-498	262	8	,	,	PUNCT
bionys-498	262	9	144(11	144(11	NUM
bionys-498	262	10	)	)	PUNCT
bionys-498	262	11	,	,	PUNCT
bionys-498	262	12	2149	2149	NUM
bionys-498	262	13	–	–	PUNCT
bionys-498	262	14	2159	2159	NUM
bionys-498	262	15	.	.	PUNCT
bionys-498	263	1	jugović	jugović	PROPN
bionys-498	263	2	et	et	PROPN
bionys-498	263	3	al	al	PROPN
bionys-498	263	4	.	.	PUNCT
bionys-498	264	1	●	●	PUNCT
bionys-498	264	2	the	the	DET
bionys-498	264	3	frequency	frequency	NOUN
bionys-498	264	4	and	and	CCONJ
bionys-498	264	5	type	type	NOUN
bionys-498	264	6	of	of	ADP
bionys-498	264	7	mutations	mutation	NOUN
bionys-498	264	8	in	in	ADP
bionys-498	264	9	the	the	DET
bionys-498	264	10	egfr	egfr	ADJ
bionys-498	264	11	gene	gene	NOUN
bionys-498	264	12	of	of	ADP
bionys-498	264	13	colorectal	colorectal	ADJ
bionys-498	264	14	carcinoma	carcinoma	NOUN
bionys-498	264	15	patients	patient	NOUN
bionys-498	264	16	in	in	ADP
bionys-498	264	17	southeastern	southeastern	ADJ
bionys-498	264	18	serbia	serbia	NOUN