id	sid	tid	token	lemma	pos
bionys-549	1	1	nagarajan	nagarajan	PROPN
bionys-549	1	2	et	et	PROPN
bionys-549	1	3	al	al	PROPN
bionys-549	1	4	.	.	PROPN
bionys-549	1	5	2024	2024	NUM
bionys-549	1	6	,	,	PUNCT
bionys-549	1	7	biologica	biologica	PROPN
bionys-549	1	8	nyssana	nyssana	PROPN
bionys-549	1	9	15(2	15(2	NUM
bionys-549	1	10	)	)	PUNCT
bionys-549	1	11	15	15	NUM
bionys-549	1	12	(	(	PUNCT
bionys-549	1	13	2	2	NUM
bionys-549	1	14	)	)	PUNCT
bionys-549	1	15	december	december	PROPN
bionys-549	1	16	2024	2024	NUM
bionys-549	1	17	:	:	PUNCT
bionys-549	1	18	123	123	NUM
bionys-549	1	19	-	-	SYM
bionys-549	1	20	133	133	NUM
bionys-549	1	21	doi	doi	NOUN
bionys-549	1	22	:	:	PUNCT
bionys-549	1	23	10.5281	10.5281	NUM
bionys-549	1	24	/	/	SYM
bionys-549	1	25	zenodo.13944121	zenodo.13944121	NOUN
bionys-549	1	26	beyond	beyond	ADP
bionys-549	1	27	boundaries	boundary	NOUN
bionys-549	1	28	:	:	PUNCT
bionys-549	1	29	pioneering	pioneer	VERB
bionys-549	1	30	discoveries	discovery	NOUN
bionys-549	1	31	in	in	ADP
bionys-549	1	32	aldose	aldose	PRON
bionys-549	1	33	reductase	reductase	NOUN
bionys-549	1	34	inhibition	inhibition	NOUN
bionys-549	1	35	for	for	ADP
bionys-549	1	36	diabetic	diabetic	ADJ
bionys-549	1	37	neuropathy	neuropathy	ADJ
bionys-549	1	38	original	original	ADJ
bionys-549	1	39	article	article	NOUN
bionys-549	1	40	nagarajan	nagarajan	NOUN
bionys-549	1	41	a.	a.	PROPN
bionys-549	1	42	department	department	PROPN
bionys-549	1	43	of	of	ADP
bionys-549	1	44	pharmaceutical	pharmaceutical	ADJ
bionys-549	1	45	chemistry	chemistry	NOUN
bionys-549	1	46	,	,	PUNCT
bionys-549	1	47	karpagam	karpagam	PROPN
bionys-549	1	48	college	college	PROPN
bionys-549	1	49	of	of	ADP
bionys-549	1	50	pharmacy	pharmacy	NOUN
bionys-549	1	51	,	,	PUNCT
bionys-549	1	52	coimbatore	coimbatore	PROPN
bionys-549	1	53	–	–	PUNCT
bionys-549	1	54	641032	641032	NUM
bionys-549	1	55	,	,	PUNCT
bionys-549	1	56	tamilnadu	tamilnadu	NOUN
bionys-549	1	57	,	,	PUNCT
bionys-549	1	58	india	india	PROPN
bionys-549	1	59	;	;	PUNCT
bionys-549	1	60	the	the	DET
bionys-549	1	61	tamil	tamil	PROPN
bionys-549	1	62	nadu	nadu	PROPN
bionys-549	1	63	dr	dr	PROPN
bionys-549	1	64	.	.	PROPN
bionys-549	1	65	m.g.r	m.g.r	PROPN
bionys-549	1	66	.	.	PUNCT
bionys-549	1	67	medical	medical	PROPN
bionys-549	1	68	university	university	PROPN
bionys-549	1	69	,	,	PUNCT
bionys-549	1	70	chennai	chennai	PROPN
bionys-549	1	71	–	–	PUNCT
bionys-549	1	72	600032	600032	NUM
bionys-549	1	73	,	,	PUNCT
bionys-549	1	74	tamilnadu	tamilnadu	NOUN
bionys-549	1	75	,	,	PUNCT
bionys-549	1	76	india	india	PROPN
bionys-549	1	77	nagarajan.a@kcp.edu.in	nagarajan.a@kcp.edu.in	PROPN
bionys-549	1	78	(	(	PUNCT
bionys-549	1	79	corresponding	corresponding	ADJ
bionys-549	1	80	author	author	NOUN
bionys-549	1	81	)	)	PUNCT
bionys-549	2	1	https://orcid.org/0000-0002-6845-934x	https://orcid.org/0000-0002-6845-934x	PROPN
bionys-549	2	2	vignesh	vignesh	PROPN
bionys-549	2	3	c.	c.	PROPN
bionys-549	2	4	department	department	PROPN
bionys-549	2	5	of	of	ADP
bionys-549	2	6	biotechnology	biotechnology	NOUN
bionys-549	2	7	,	,	PUNCT
bionys-549	2	8	sastra	sastra	PROPN
bionys-549	2	9	university	university	PROPN
bionys-549	2	10	,	,	PUNCT
bionys-549	2	11	thanjavur	thanjavur	NOUN
bionys-549	2	12	,	,	PUNCT
bionys-549	2	13	tamilnadu	tamilnadu	PROPN
bionys-549	2	14	,	,	PUNCT
bionys-549	2	15	india	india	PROPN
bionys-549	2	16	ramasamy	ramasamy	PROPN
bionys-549	2	17	t.	t.	PROPN
bionys-549	2	18	department	department	PROPN
bionys-549	2	19	of	of	ADP
bionys-549	2	20	biotechnology	biotechnology	NOUN
bionys-549	2	21	,	,	PUNCT
bionys-549	2	22	ennam	ennam	NOUN
bionys-549	2	23	college	college	PROPN
bionys-549	2	24	of	of	ADP
bionys-549	2	25	pharmacy	pharmacy	NOUN
bionys-549	2	26	,	,	PUNCT
bionys-549	2	27	kinathukadavu	kinathukadavu	PROPN
bionys-549	2	28	taluk	taluk	PROPN
bionys-549	2	29	,	,	PUNCT
bionys-549	2	30	coimbatore	coimbatore	PROPN
bionys-549	2	31	641032	641032	NUM
bionys-549	2	32	coimbatore	coimbatore	PROPN
bionys-549	2	33	–	–	PUNCT
bionys-549	2	34	641032	641032	NUM
bionys-549	2	35	,	,	PUNCT
bionys-549	2	36	tamilnadu	tamilnadu	NOUN
bionys-549	2	37	,	,	PUNCT
bionys-549	2	38	india	india	PROPN
bionys-549	2	39	sasikala	sasikala	PROPN
bionys-549	2	40	m.	m.	PROPN
bionys-549	2	41	department	department	PROPN
bionys-549	2	42	of	of	ADP
bionys-549	2	43	pharmaceutical	pharmaceutical	ADJ
bionys-549	2	44	analysis	analysis	NOUN
bionys-549	2	45	,	,	PUNCT
bionys-549	2	46	karpagam	karpagam	PROPN
bionys-549	2	47	college	college	PROPN
bionys-549	2	48	of	of	ADP
bionys-549	2	49	pharmacy	pharmacy	NOUN
bionys-549	2	50	,	,	PUNCT
bionys-549	2	51	coimbatore	coimbatore	PROPN
bionys-549	2	52	–	–	PUNCT
bionys-549	2	53	641032	641032	NUM
bionys-549	2	54	,	,	PUNCT
bionys-549	2	55	tamilnadu	tamilnadu	NOUN
bionys-549	2	56	,	,	PUNCT
bionys-549	2	57	india	india	PROPN
bionys-549	2	58	;	;	PUNCT
bionys-549	2	59	the	the	DET
bionys-549	2	60	tamil	tamil	PROPN
bionys-549	2	61	nadu	nadu	PROPN
bionys-549	2	62	dr	dr	PROPN
bionys-549	2	63	.	.	PROPN
bionys-549	2	64	m.g.r	m.g.r	PROPN
bionys-549	2	65	.	.	PUNCT
bionys-549	2	66	medical	medical	PROPN
bionys-549	2	67	university	university	PROPN
bionys-549	2	68	,	,	PUNCT
bionys-549	2	69	chennai	chennai	PROPN
bionys-549	2	70	–	–	PUNCT
bionys-549	2	71	600032	600032	NUM
bionys-549	2	72	,	,	PUNCT
bionys-549	2	73	tamilnadu	tamilnadu	NOUN
bionys-549	2	74	,	,	PUNCT
bionys-549	2	75	india	india	PROPN
bionys-549	2	76	mohan	mohan	PROPN
bionys-549	2	77	s.	s.	PROPN
bionys-549	2	78	department	department	PROPN
bionys-549	2	79	of	of	ADP
bionys-549	2	80	pharmaceutics	pharmaceutics	PROPN
bionys-549	2	81	,	,	PUNCT
bionys-549	2	82	karpagam	karpagam	PROPN
bionys-549	2	83	college	college	PROPN
bionys-549	2	84	of	of	ADP
bionys-549	2	85	pharmacy	pharmacy	NOUN
bionys-549	2	86	,	,	PUNCT
bionys-549	2	87	coimbatore	coimbatore	PROPN
bionys-549	2	88	–	–	PUNCT
bionys-549	2	89	641032	641032	NUM
bionys-549	2	90	,	,	PUNCT
bionys-549	2	91	tamilnadu	tamilnadu	NOUN
bionys-549	2	92	,	,	PUNCT
bionys-549	2	93	india	india	PROPN
bionys-549	2	94	;	;	PUNCT
bionys-549	2	95	the	the	DET
bionys-549	2	96	tamil	tamil	PROPN
bionys-549	2	97	nadu	nadu	PROPN
bionys-549	2	98	dr	dr	PROPN
bionys-549	2	99	.	.	PROPN
bionys-549	2	100	m.g.r	m.g.r	PROPN
bionys-549	2	101	.	.	PUNCT
bionys-549	2	102	medical	medical	PROPN
bionys-549	2	103	university	university	PROPN
bionys-549	2	104	,	,	PUNCT
bionys-549	2	105	chennai	chennai	PROPN
bionys-549	2	106	–	–	PUNCT
bionys-549	2	107	600032	600032	NUM
bionys-549	2	108	,	,	PUNCT
bionys-549	2	109	tamilnadu	tamilnadu	NOUN
bionys-549	2	110	,	,	PUNCT
bionys-549	2	111	india	india	PROPN
bionys-549	2	112	received	receive	VERB
bionys-549	2	113	:	:	PUNCT
bionys-549	2	114	august	august	PROPN
bionys-549	2	115	27	27	NUM
bionys-549	2	116	,	,	PUNCT
bionys-549	2	117	2024	2024	NUM
bionys-549	2	118	revised	revise	VERB
bionys-549	2	119	:	:	PUNCT
bionys-549	2	120	september	september	PROPN
bionys-549	2	121	25	25	NUM
bionys-549	2	122	,	,	PUNCT
bionys-549	2	123	2024	2024	NUM
bionys-549	2	124	accepted	accept	VERB
bionys-549	2	125	:	:	PUNCT
bionys-549	2	126	september	september	PROPN
bionys-549	2	127	30	30	NUM
bionys-549	2	128	,	,	PUNCT
bionys-549	2	129	2024	2024	NUM
bionys-549	2	130	abstract	abstract	NOUN
bionys-549	2	131	:	:	PUNCT
bionys-549	2	132	aldose	aldose	DET
bionys-549	2	133	reductase	reductase	NOUN
bionys-549	2	134	enzyme	enzyme	NOUN
bionys-549	2	135	is	be	AUX
bionys-549	2	136	involved	involve	VERB
bionys-549	2	137	in	in	ADP
bionys-549	2	138	key	key	ADJ
bionys-549	2	139	step	step	NOUN
bionys-549	2	140	controlling	control	VERB
bionys-549	2	141	the	the	DET
bionys-549	2	142	polyol	polyol	NOUN
bionys-549	2	143	pathway	pathway	NOUN
bionys-549	2	144	and	and	CCONJ
bionys-549	2	145	acknowledged	acknowledge	VERB
bionys-549	2	146	as	as	ADP
bionys-549	2	147	a	a	DET
bionys-549	2	148	possible	possible	ADJ
bionys-549	2	149	target	target	NOUN
bionys-549	2	150	for	for	ADP
bionys-549	2	151	diabetic	diabetic	ADJ
bionys-549	2	152	neuropathy	neuropathy	ADJ
bionys-549	2	153	.	.	PUNCT
bionys-549	3	1	the	the	DET
bionys-549	3	2	anionic	anionic	ADJ
bionys-549	3	3	region	region	NOUN
bionys-549	3	4	of	of	ADP
bionys-549	3	5	the	the	DET
bionys-549	3	6	active	active	ADJ
bionys-549	3	7	site	site	NOUN
bionys-549	3	8	comprising	comprising	NOUN
bionys-549	3	9	residues	residue	NOUN
bionys-549	3	10	his110	his110	NOUN
bionys-549	3	11	and	and	CCONJ
bionys-549	3	12	tyr48	tyr48	NOUN
bionys-549	3	13	is	be	AUX
bionys-549	3	14	involved	involve	VERB
bionys-549	3	15	in	in	ADP
bionys-549	3	16	the	the	DET
bionys-549	3	17	detoxification	detoxification	NOUN
bionys-549	3	18	mechanism	mechanism	NOUN
bionys-549	3	19	that	that	PRON
bionys-549	3	20	is	be	AUX
bionys-549	3	21	considered	consider	VERB
bionys-549	3	22	important	important	ADJ
bionys-549	3	23	.	.	PUNCT
bionys-549	4	1	this	this	DET
bionys-549	4	2	process	process	NOUN
bionys-549	4	3	involves	involve	VERB
bionys-549	4	4	eliminating	eliminate	VERB
bionys-549	4	5	toxicity	toxicity	NOUN
bionys-549	4	6	through	through	ADP
bionys-549	4	7	conversion	conversion	NOUN
bionys-549	4	8	of	of	ADP
bionys-549	4	9	aldehydes	aldehyde	NOUN
bionys-549	4	10	such	such	ADJ
bionys-549	4	11	as	as	ADP
bionys-549	4	12	methylglyoxal	methylglyoxal	NOUN
bionys-549	4	13	(	(	PUNCT
bionys-549	4	14	meg	meg	NOUN
bionys-549	4	15	)	)	PUNCT
bionys-549	4	16	and	and	CCONJ
bionys-549	4	17	3	3	NUM
bionys-549	4	18	-	-	PUNCT
bionys-549	4	19	deoxyglucosone	deoxyglucosone	NOUN
bionys-549	4	20	.	.	PUNCT
bionys-549	5	1	so	so	ADV
bionys-549	5	2	far	far	ADV
bionys-549	5	3	,	,	PUNCT
bionys-549	5	4	no	no	DET
bionys-549	5	5	drug	drug	NOUN
bionys-549	5	6	has	have	AUX
bionys-549	5	7	been	be	AUX
bionys-549	5	8	developed	develop	VERB
bionys-549	5	9	that	that	PRON
bionys-549	5	10	could	could	AUX
bionys-549	5	11	selectively	selectively	ADV
bionys-549	5	12	inhibit	inhibit	VERB
bionys-549	5	13	reduction	reduction	NOUN
bionys-549	5	14	of	of	ADP
bionys-549	5	15	glucose	glucose	NOUN
bionys-549	5	16	to	to	PART
bionys-549	5	17	sorbitol	sorbitol	VERB
bionys-549	5	18	without	without	ADP
bionys-549	5	19	affecting	affect	VERB
bionys-549	5	20	the	the	DET
bionys-549	5	21	detoxification	detoxification	NOUN
bionys-549	5	22	mechanism	mechanism	NOUN
bionys-549	5	23	.	.	PUNCT
bionys-549	6	1	to	to	PART
bionys-549	6	2	comprehend	comprehend	VERB
bionys-549	6	3	the	the	DET
bionys-549	6	4	critical	critical	ADJ
bionys-549	6	5	interactions	interaction	NOUN
bionys-549	6	6	of	of	ADP
bionys-549	6	7	the	the	DET
bionys-549	6	8	known	know	VERB
bionys-549	6	9	aldose	aldose	ADJ
bionys-549	6	10	reductase	reductase	NOUN
bionys-549	6	11	inhibitors	inhibitor	NOUN
bionys-549	6	12	and	and	CCONJ
bionys-549	6	13	the	the	DET
bionys-549	6	14	enzyme	enzyme	NOUN
bionys-549	6	15	,	,	PUNCT
bionys-549	6	16	molecular	molecular	ADJ
bionys-549	6	17	docking	docking	NOUN
bionys-549	6	18	was	be	AUX
bionys-549	6	19	conducted	conduct	VERB
bionys-549	6	20	in	in	ADP
bionys-549	6	21	this	this	DET
bionys-549	6	22	study	study	NOUN
bionys-549	6	23	.	.	PUNCT
bionys-549	7	1	anionic	anionic	ADJ
bionys-549	7	2	region	region	NOUN
bionys-549	7	3	,	,	PUNCT
bionys-549	7	4	specificity	specificity	NOUN
bionys-549	7	5	region	region	NOUN
bionys-549	7	6	and	and	CCONJ
bionys-549	7	7	the	the	DET
bionys-549	7	8	active	active	ADJ
bionys-549	7	9	site	site	NOUN
bionys-549	7	10	are	be	AUX
bionys-549	7	11	the	the	DET
bionys-549	7	12	three	three	NUM
bionys-549	7	13	regions	region	NOUN
bionys-549	7	14	used	use	VERB
bionys-549	7	15	separately	separately	ADV
bionys-549	7	16	for	for	ADP
bionys-549	7	17	grid	grid	NOUN
bionys-549	7	18	molecular	molecular	ADJ
bionys-549	7	19	docking	docking	NOUN
bionys-549	7	20	studies	study	NOUN
bionys-549	7	21	to	to	PART
bionys-549	7	22	identify	identify	VERB
bionys-549	7	23	the	the	DET
bionys-549	7	24	possible	possible	ADJ
bionys-549	7	25	inhibitors	inhibitor	NOUN
bionys-549	7	26	that	that	PRON
bionys-549	7	27	selectively	selectively	ADV
bionys-549	7	28	bind	bind	VERB
bionys-549	7	29	to	to	ADP
bionys-549	7	30	specificity	specificity	NOUN
bionys-549	7	31	region	region	NOUN
bionys-549	7	32	.	.	PUNCT
bionys-549	8	1	among	among	ADP
bionys-549	8	2	the	the	DET
bionys-549	8	3	docked	dock	VERB
bionys-549	8	4	compounds	compound	NOUN
bionys-549	8	5	,	,	PUNCT
bionys-549	8	6	quercetin	quercetin	NOUN
bionys-549	8	7	was	be	AUX
bionys-549	8	8	found	find	VERB
bionys-549	8	9	to	to	PART
bionys-549	8	10	bind	bind	VERB
bionys-549	8	11	to	to	ADP
bionys-549	8	12	specificity	specificity	NOUN
bionys-549	8	13	region	region	NOUN
bionys-549	8	14	,	,	PUNCT
bionys-549	8	15	so	so	SCONJ
bionys-549	8	16	we	we	PRON
bionys-549	8	17	chose	chose	AUX
bionys-549	8	18	reported	report	VERB
bionys-549	8	19	quercetin	quercetin	NOUN
bionys-549	8	20	analogue	analogue	NOUN
bionys-549	8	21	and	and	CCONJ
bionys-549	8	22	built	build	VERB
bionys-549	8	23	a	a	DET
bionys-549	8	24	pharmacophore	pharmacophore	NOUN
bionys-549	8	25	model	model	NOUN
bionys-549	8	26	.	.	PUNCT
bionys-549	9	1	subsequently	subsequently	ADV
bionys-549	9	2	,	,	PUNCT
bionys-549	9	3	a	a	DET
bionys-549	9	4	collection	collection	NOUN
bionys-549	9	5	of	of	ADP
bionys-549	9	6	82,000	82,000	NUM
bionys-549	9	7	natural	natural	ADJ
bionys-549	9	8	substances	substance	NOUN
bionys-549	9	9	from	from	ADP
bionys-549	9	10	the	the	DET
bionys-549	9	11	ibs	ibs	PROPN
bionys-549	9	12	databank	databank	PROPN
bionys-549	9	13	(	(	PUNCT
bionys-549	9	14	interbioscreen	interbioscreen	VERB
bionys-549	9	15	)	)	PUNCT
bionys-549	9	16	was	be	AUX
bionys-549	9	17	searched	search	VERB
bionys-549	9	18	using	use	VERB
bionys-549	9	19	a	a	DET
bionys-549	9	20	6	6	NUM
bionys-549	9	21	-	-	PUNCT
bionys-549	9	22	point	point	NOUN
bionys-549	9	23	pharmacophore	pharmacophore	NOUN
bionys-549	9	24	(	(	PUNCT
bionys-549	9	25	aaarrr	aaarrr	PROPN
bionys-549	9	26	)	)	PUNCT
bionys-549	9	27	that	that	PRON
bionys-549	9	28	was	be	AUX
bionys-549	9	29	created	create	VERB
bionys-549	9	30	.	.	PUNCT
bionys-549	10	1	after	after	SCONJ
bionys-549	10	2	the	the	DET
bionys-549	10	3	initial	initial	ADJ
bionys-549	10	4	search	search	NOUN
bionys-549	10	5	returned	return	VERB
bionys-549	10	6	2,394	2,394	NUM
bionys-549	10	7	hits	hit	NOUN
bionys-549	10	8	,	,	PUNCT
bionys-549	10	9	a	a	DET
bionys-549	10	10	hierarchical	hierarchical	ADJ
bionys-549	10	11	docking	docking	NOUN
bionys-549	10	12	approach	approach	NOUN
bionys-549	10	13	was	be	AUX
bionys-549	10	14	used	use	VERB
bionys-549	10	15	to	to	PART
bionys-549	10	16	identify	identify	VERB
bionys-549	10	17	an	an	DET
bionys-549	10	18	intriguing	intriguing	ADJ
bionys-549	10	19	hit	hit	VERB
bionys-549	10	20	molecule	molecule	NOUN
bionys-549	10	21	(	(	PUNCT
bionys-549	10	22	mol_7921	mol_7921	NUM
bionys-549	10	23	)	)	PUNCT
bionys-549	10	24	,	,	PUNCT
bionys-549	10	25	which	which	PRON
bionys-549	10	26	is	be	AUX
bionys-549	10	27	quite	quite	ADV
bionys-549	10	28	close	close	ADJ
bionys-549	10	29	to	to	ADP
bionys-549	10	30	a	a	DET
bionys-549	10	31	flavonoid	flavonoid	NOUN
bionys-549	10	32	compound	compound	NOUN
bionys-549	10	33	.	.	PUNCT
bionys-549	11	1	molecular	molecular	ADJ
bionys-549	11	2	dynamics	dynamic	NOUN
bionys-549	11	3	simulation	simulation	NOUN
bionys-549	11	4	was	be	AUX
bionys-549	11	5	used	use	VERB
bionys-549	11	6	to	to	PART
bionys-549	11	7	confirm	confirm	VERB
bionys-549	11	8	the	the	DET
bionys-549	11	9	hit	hit	VERB
bionys-549	11	10	molecule	molecule	NOUN
bionys-549	11	11	-	-	PUNCT
bionys-549	11	12	aldose	aldose	NOUN
bionys-549	11	13	reductase	reductase	NOUN
bionys-549	11	14	complex	complex	NOUN
bionys-549	11	15	’s	’s	PART
bionys-549	11	16	structural	structural	ADJ
bionys-549	11	17	stability	stability	NOUN
bionys-549	11	18	.	.	PUNCT
bionys-549	12	1	for	for	ADP
bionys-549	12	2	its	its	PRON
bionys-549	12	3	possible	possible	ADJ
bionys-549	12	4	inhibitory	inhibitory	ADJ
bionys-549	12	5	effect	effect	NOUN
bionys-549	12	6	,	,	PUNCT
bionys-549	12	7	this	this	DET
bionys-549	12	8	molecule	molecule	NOUN
bionys-549	12	9	could	could	AUX
bionys-549	12	10	be	be	AUX
bionys-549	12	11	tested	test	VERB
bionys-549	12	12	and	and	CCONJ
bionys-549	12	13	used	use	VERB
bionys-549	12	14	to	to	PART
bionys-549	12	15	treat	treat	VERB
bionys-549	12	16	diabetic	diabetic	ADJ
bionys-549	12	17	neuropathy	neuropathy	ADJ
bionys-549	12	18	.	.	PUNCT
bionys-549	13	1	key	key	ADJ
bionys-549	13	2	words	word	NOUN
bionys-549	13	3	:	:	PUNCT
bionys-549	13	4	diabetic	diabetic	ADJ
bionys-549	13	5	neuropathy	neuropathy	ADJ
bionys-549	13	6	,	,	PUNCT
bionys-549	13	7	polyol	polyol	NOUN
bionys-549	13	8	pathway	pathway	NOUN
bionys-549	13	9	,	,	PUNCT
bionys-549	13	10	methylglyoxal	methylglyoxal	NOUN
bionys-549	13	11	,	,	PUNCT
bionys-549	13	12	quercetin	quercetin	NOUN
bionys-549	13	13	,	,	PUNCT
bionys-549	13	14	virtual	virtual	ADJ
bionys-549	13	15	screening	screening	NOUN
bionys-549	13	16	,	,	PUNCT
bionys-549	13	17	inhibitors	inhibitor	NOUN
bionys-549	13	18	apstrakt	apstrakt	VERB
bionys-549	13	19	:	:	PUNCT
bionys-549	13	20	iza	iza	PROPN
bionys-549	13	21	granica	granica	PROPN
bionys-549	13	22	:	:	PUNCT
bionys-549	13	23	pionirska	pionirska	PROPN
bionys-549	13	24	otkrića	otkrića	PROPN
bionys-549	13	25	u	u	PROPN
bionys-549	13	26	inhibiciji	inhibiciji	PROPN
bionys-549	13	27	aldoza	aldoza	PROPN
bionys-549	13	28	reduktaze	reduktaze	PROPN
bionys-549	13	29	za	za	PROPN
bionys-549	13	30	dijabetičku	dijabetičku	ADJ
bionys-549	13	31	neuropatiju	neuropatiju	PROPN
bionys-549	13	32	enzim	enzim	PROPN
bionys-549	13	33	aldoza	aldoza	PROPN
bionys-549	13	34	reduktaza	reduktaza	PROPN
bionys-549	13	35	je	je	PROPN
bionys-549	13	36	uključen	uključen	VERB
bionys-549	14	1	u	u	PRON
bionys-549	14	2	ključni	ključni	PROPN
bionys-549	14	3	korak	korak	PROPN
bionys-549	14	4	kontrole	kontrole	PROPN
bionys-549	14	5	poliolnog	poliolnog	PROPN
bionys-549	14	6	puta	puta	NOUN
bionys-549	14	7	i	i	PRON
bionys-549	14	8	prepoznat	prepoznat	VERB
bionys-549	14	9	je	je	PROPN
bionys-549	14	10	kao	kao	PROPN
bionys-549	14	11	moguća	moguća	VERB
bionys-549	14	12	meta	meta	PROPN
bionys-549	14	13	za	za	PROPN
bionys-549	14	14	dijabetičku	dijabetičku	PROPN
bionys-549	14	15	neuropatiju	neuropatiju	PROPN
bionys-549	14	16	.	.	PUNCT
bionys-549	15	1	anjonski	anjonski	PROPN
bionys-549	15	2	region	region	PROPN
bionys-549	15	3	aktivnog	aktivnog	PROPN
bionys-549	15	4	mesta	mesta	PROPN
bionys-549	15	5	,	,	PUNCT
bionys-549	15	6	koji	koji	PROPN
bionys-549	15	7	obuhvata	obuhvata	PROPN
bionys-549	15	8	ostatke	ostatke	PROPN
bionys-549	15	9	his110	his110	PROPN
bionys-549	15	10	i	i	PRON
bionys-549	15	11	tyr48	tyr48	VERB
bionys-549	15	12	,	,	PUNCT
bionys-549	15	13	uključen	uključen	VERB
bionys-549	15	14	je	je	PROPN
bionys-549	15	15	u	u	PROPN
bionys-549	15	16	mehanizam	mehanizam	PROPN
bionys-549	15	17	detoksikacije	detoksikacije	PROPN
bionys-549	15	18	koji	koji	PROPN
bionys-549	15	19	se	se	PROPN
bionys-549	15	20	smatra	smatra	PROPN
bionys-549	15	21	važnim	važnim	PROPN
bionys-549	15	22	.	.	PUNCT
bionys-549	16	1	ovaj	ovaj	PROPN
bionys-549	16	2	proces	proces	PROPN
bionys-549	16	3	podrazumeva	podrazumeva	ADJ
bionys-549	16	4	eliminaciju	eliminaciju	PROPN
bionys-549	16	5	toksičnosti	toksičnosti	PROPN
bionys-549	16	6	kroz	kroz	PROPN
bionys-549	16	7	konverziju	konverziju	PROPN
bionys-549	16	8	aldehida	aldehida	PROPN
bionys-549	16	9	,	,	PUNCT
bionys-549	16	10	kao	kao	PROPN
bionys-549	16	11	što	što	PROPN
bionys-549	16	12	su	su	PROPN
bionys-549	16	13	metil	metil	PROPN
bionys-549	16	14	glioksal	glioksal	PROPN
bionys-549	16	15	(	(	PUNCT
bionys-549	16	16	meg	meg	PROPN
bionys-549	16	17	)	)	PUNCT
bionys-549	16	18	i	i	PRON
bionys-549	16	19	3	3	NUM
bionys-549	16	20	-	-	PUNCT
bionys-549	16	21	dezoksiglukozon	dezoksiglukozon	NOUN
bionys-549	16	22	.	.	PUNCT
bionys-549	17	1	do	do	VERB
bionys-549	17	2	sada	sada	PROPN
bionys-549	17	3	nije	nije	PROPN
bionys-549	17	4	razvijen	razvijen	PROPN
bionys-549	17	5	nijedan	nijedan	PROPN
bionys-549	17	6	lek	lek	PROPN
bionys-549	17	7	koji	koji	PROPN
bionys-549	17	8	bi	bi	PROPN
bionys-549	17	9	mogao	mogao	PROPN
bionys-549	17	10	selektivno	selektivno	NOUN
bionys-549	17	11	inhibirati	inhibirati	NOUN
bionys-549	17	12	redukciju	redukciju	ADJ
bionys-549	17	13	glukoze	glukoze	NOUN
bionys-549	17	14	u	u	PROPN
bionys-549	17	15	sorbitol	sorbitol	NOUN
bionys-549	17	16	bez	bez	PROPN
bionys-549	17	17	uticaja	uticaja	PROPN
bionys-549	17	18	na	na	PROPN
bionys-549	17	19	mehanizam	mehanizam	PROPN
bionys-549	17	20	detoksikacije	detoksikacije	PROPN
bionys-549	17	21	.	.	PUNCT
bionys-549	18	1	kako	kako	PROPN
bionys-549	18	2	bismo	bismo	PROPN
bionys-549	18	3	razumeli	razumeli	VERB
bionys-549	18	4	ključne	ključne	PROPN
bionys-549	18	5	interakcije	interakcije	PROPN
bionys-549	18	6	poznatih	poznatih	PROPN
bionys-549	18	7	inhibitora	inhibitora	PROPN
bionys-549	18	8	aldoza	aldoza	PROPN
bionys-549	18	9	reduktaze	reduktaze	PROPN
bionys-549	19	1	i	i	PRON
bionys-549	19	2	enzima	enzima	VERB
bionys-549	19	3	,	,	PUNCT
bionys-549	19	4	sprovedeno	sprovedeno	PROPN
bionys-549	19	5	je	je	PROPN
bionys-549	19	6	molekulsko	molekulsko	PROPN
bionys-549	19	7	dokovanje	dokovanje	PROPN
bionys-549	19	8	u	u	PROPN
bionys-549	19	9	ovoj	ovoj	PROPN
bionys-549	19	10	studiji	studiji	PROPN
bionys-549	19	11	.	.	PUNCT
bionys-549	20	1	anjonska	anjonska	ADJ
bionys-549	20	2	regija	regija	NOUN
bionys-549	20	3	,	,	PUNCT
bionys-549	20	4	specifična	specifična	NOUN
bionys-549	20	5	regija	regija	NOUN
bionys-549	20	6	i	i	PRON
bionys-549	20	7	aktivno	aktivno	VERB
bionys-549	20	8	mesto	mesto	PROPN
bionys-549	20	9	su	su	PROPN
bionys-549	20	10	tri	tri	PROPN
bionys-549	20	11	regije	regije	PROPN
bionys-549	20	12	korišćene	korišćene	PROPN
bionys-549	20	13	zasebno	zasebno	PROPN
bionys-549	20	14	za	za	PROPN
bionys-549	21	1	dokovanje	dokovanje	PROPN
bionys-549	21	2	molekula	molekula	PROPN
bionys-549	21	3	kako	kako	PROPN
bionys-549	21	4	bi	bi	PROPN
bionys-549	21	5	se	se	PROPN
bionys-549	21	6	identifikovali	identifikovali	VERB
bionys-549	21	7	mogući	mogući	PROPN
bionys-549	21	8	inhibitori	inhibitori	PROPN
bionys-549	21	9	koji	koji	PROPN
bionys-549	21	10	se	se	PROPN
bionys-549	21	11	selektivno	selektivno	PROPN
bionys-549	21	12	vezuju	vezuju	PROPN
bionys-549	21	13	za	za	PROPN
bionys-549	21	14	specifičnu	specifičnu	PROPN
bionys-549	21	15	regiju	regiju	NOUN
bionys-549	21	16	.	.	PUNCT
bionys-549	22	1	među	među	PROPN
bionys-549	22	2	dokovanim	dokovanim	PROPN
bionys-549	22	3	jedinjenjima	jedinjenjima	PROPN
bionys-549	22	4	,	,	PUNCT
bionys-549	22	5	ustanovljeno	ustanovljeno	PROPN
bionys-549	22	6	je	je	PROPN
bionys-549	22	7	da	da	PROPN
bionys-549	22	8	se	se	PROPN
bionys-549	22	9	kvercetin	kvercetin	PROPN
bionys-549	22	10	vezuje	vezuje	PROPN
bionys-549	22	11	za	za	PROPN
bionys-549	22	12	specifičnu	specifičnu	PROPN
bionys-549	22	13	regiju	regiju	NOUN
bionys-549	23	1	,	,	PUNCT
bionys-549	23	2	pa	pa	PROPN
bionys-549	23	3	smo	smo	PROPN
bionys-549	23	4	odabrali	odabrali	PROPN
bionys-549	23	5	prijavljeni	prijavljeni	ADJ
bionys-549	23	6	analog	analog	PROPN
bionys-549	23	7	kvercetina	kvercetina	PROPN
bionys-549	23	8	i	i	PROPN
bionys-549	23	9	izgradili	izgradili	PROPN
bionys-549	23	10	farmakoforski	farmakoforski	PROPN
bionys-549	23	11	model	model	NOUN
bionys-549	23	12	.	.	PUNCT
bionys-549	24	1	nakon	nakon	PROPN
bionys-549	24	2	toga	toga	PROPN
bionys-549	24	3	,	,	PUNCT
bionys-549	24	4	pretraženo	pretraženo	PROPN
bionys-549	24	5	je	je	PROPN
bionys-549	24	6	82.000	82.000	NUM
bionys-549	24	7	prirodnih	prirodnih	NOUN
bionys-549	24	8	supstanci	supstanci	PROPN
bionys-549	24	9	iz	iz	INTJ
bionys-549	24	10	ibs	ibs	PROPN
bionys-549	24	11	baze	baze	PROPN
bionys-549	24	12	podataka	podataka	PROPN
bionys-549	24	13	(	(	PUNCT
bionys-549	24	14	interbioscreen	interbioscreen	ADJ
bionys-549	24	15	)	)	PUNCT
bionys-549	24	16	koristeći	koristeći	VERB
bionys-549	24	17	farmakofor	farmakofor	PROPN
bionys-549	24	18	sa	sa	PROPN
bionys-549	24	19	6	6	NUM
bionys-549	24	20	tačaka	tačaka	NOUN
bionys-549	24	21	(	(	PUNCT
bionys-549	24	22	aaarrr	aaarrr	PROPN
bionys-549	24	23	)	)	PUNCT
bionys-549	24	24	.	.	PUNCT
bionys-549	25	1	početna	početna	PROPN
bionys-549	25	2	pretraga	pretraga	PROPN
bionys-549	25	3	vratila	vratila	PROPN
bionys-549	25	4	je	je	PROPN
bionys-549	25	5	2.394	2.394	NUM
bionys-549	25	6	pogodaka	pogodaka	PROPN
bionys-549	25	7	,	,	PUNCT
bionys-549	25	8	nakon	nakon	PROPN
bionys-549	25	9	čega	čega	PROPN
bionys-549	25	10	je	je	PROPN
bionys-549	25	11	korišćen	korišćen	PROPN
bionys-549	25	12	hijerarhijski	hijerarhijski	PROPN
bionys-549	25	13	pristup	pristup	PROPN
bionys-549	25	14	dokovanju	dokovanju	PROPN
bionys-549	25	15	kako	kako	PROPN
bionys-549	25	16	bi	bi	PROPN
bionys-549	25	17	se	se	PROPN
bionys-549	25	18	identifikovalo	identifikovalo	PROPN
bionys-549	25	19	ciljno	ciljno	PROPN
bionys-549	25	20	jedinjenje	jedinjenje	PROPN
bionys-549	25	21	(	(	PUNCT
bionys-549	25	22	mol_7921	mol_7921	NUM
bionys-549	25	23	)	)	PUNCT
bionys-549	25	24	,	,	PUNCT
bionys-549	25	25	koje	koje	PROPN
bionys-549	25	26	je	je	PROPN
bionys-549	25	27	veoma	veoma	PROPN
bionys-549	25	28	blisko	blisko	PROPN
bionys-549	25	29	flavonoidnom	flavonoidnom	PROPN
bionys-549	25	30	jedinjenju	jedinjenju	PROPN
bionys-549	25	31	.	.	PUNCT
bionys-549	26	1	simulacija	simulacija	VERB
bionys-549	26	2	molekulske	molekulske	PROPN
bionys-549	26	3	dinamike	dinamike	PROPN
bionys-549	26	4	je	je	PROPN
bionys-549	26	5	korišćena	korišćena	PROPN
bionys-549	26	6	da	da	PROPN
bionys-549	26	7	potvrdi	potvrdi	PROPN
bionys-549	26	8	strukturnu	strukturnu	PROPN
bionys-549	26	9	stabilnost	stabilnost	PROPN
bionys-549	27	1	kompleksa	kompleksa	PROPN
bionys-549	27	2	ciljnog	ciljnog	PROPN
bionys-549	27	3	molekula	molekula	VERB
bionys-549	28	1	i	i	PRON
bionys-549	28	2	aldoza	aldoza	VERB
bionys-549	28	3	reduktaze	reduktaze	ADJ
bionys-549	28	4	.	.	PUNCT
bionys-549	29	1	ovo	ovo	PROPN
bionys-549	29	2	jedinjenje	jedinjenje	PROPN
bionys-549	29	3	bi	bi	PROPN
bionys-549	29	4	moglo	moglo	PROPN
bionys-549	29	5	biti	biti	PROPN
bionys-549	29	6	testirano	testirano	PROPN
bionys-549	30	1	i	i	PRON
bionys-549	30	2	korišćeno	korišćeno	VERB
bionys-549	30	3	za	za	PROPN
bionys-549	30	4	lečenje	lečenje	PROPN
bionys-549	30	5	dijabetičke	dijabetičke	PROPN
bionys-549	30	6	neuropatije	neuropatije	PROPN
bionys-549	30	7	zbog	zbog	PROPN
bionys-549	30	8	svog	svog	PROPN
bionys-549	30	9	mogućeg	mogućeg	PROPN
bionys-549	30	10	inhibitornog	inhibitornog	PROPN
bionys-549	30	11	efekta	efekta	PROPN
bionys-549	30	12	.	.	PUNCT
bionys-549	31	1	ključne	ključne	PROPN
bionys-549	31	2	reči	reči	NOUN
bionys-549	31	3	:	:	PUNCT
bionys-549	31	4	dijabetička	dijabetička	NOUN
bionys-549	31	5	neuropatija	neuropatija	NOUN
bionys-549	31	6	,	,	PUNCT
bionys-549	31	7	put	put	VERB
bionys-549	31	8	poliola	poliola	NOUN
bionys-549	31	9	,	,	PUNCT
bionys-549	31	10	metil	metil	PROPN
bionys-549	31	11	glioksal	glioksal	NOUN
bionys-549	31	12	,	,	PUNCT
bionys-549	31	13	kvercetin	kvercetin	PROPN
bionys-549	31	14	,	,	PUNCT
bionys-549	31	15	virtualni	virtualni	NOUN
bionys-549	31	16	skrining	skrining	NOUN
bionys-549	31	17	,	,	PUNCT
bionys-549	31	18	inhibitori	inhibitori	NOUN
bionys-549	31	19	©	©	PROPN
bionys-549	31	20	2024	2024	NUM
bionys-549	31	21	nagarajan	nagarajan	NOUN
bionys-549	31	22	et	et	PROPN
bionys-549	31	23	al	al	PROPN
bionys-549	31	24	.	.	PUNCT
bionys-549	32	1	this	this	PRON
bionys-549	32	2	is	be	AUX
bionys-549	32	3	an	an	DET
bionys-549	32	4	open	open	ADJ
bionys-549	32	5	-	-	PUNCT
bionys-549	32	6	access	access	NOUN
bionys-549	32	7	article	article	NOUN
bionys-549	32	8	distributed	distribute	VERB
bionys-549	32	9	under	under	ADP
bionys-549	32	10	the	the	DET
bionys-549	32	11	terms	term	NOUN
bionys-549	32	12	of	of	ADP
bionys-549	32	13	the	the	DET
bionys-549	32	14	creative	creative	ADJ
bionys-549	32	15	commons	common	NOUN
bionys-549	32	16	attribution	attribution	NOUN
bionys-549	32	17	license	license	NOUN
bionys-549	32	18	,	,	PUNCT
bionys-549	32	19	which	which	PRON
bionys-549	32	20	permits	permit	VERB
bionys-549	32	21	unrestricted	unrestricted	ADJ
bionys-549	32	22	use	use	NOUN
bionys-549	32	23	,	,	PUNCT
bionys-549	32	24	distribution	distribution	NOUN
bionys-549	32	25	,	,	PUNCT
bionys-549	32	26	and	and	CCONJ
bionys-549	32	27	build	build	VERB
bionys-549	32	28	upon	upon	SCONJ
bionys-549	32	29	your	your	PRON
bionys-549	32	30	work	work	NOUN
bionys-549	32	31	non	non	ADJ
bionys-549	32	32	-	-	ADJ
bionys-549	32	33	commercially	commercially	ADV
bionys-549	32	34	under	under	ADP
bionys-549	32	35	the	the	DET
bionys-549	32	36	same	same	ADJ
bionys-549	32	37	license	license	NOUN
bionys-549	32	38	as	as	ADP
bionys-549	32	39	the	the	DET
bionys-549	32	40	original	original	ADJ
bionys-549	32	41	.	.	PUNCT
bionys-549	33	1	123	123	NUM
bionys-549	33	2	introduction	introduction	NOUN
bionys-549	33	3	diabetic	diabetic	ADJ
bionys-549	33	4	neuropathy	neuropathy	ADJ
bionys-549	33	5	is	be	AUX
bionys-549	33	6	a	a	DET
bionys-549	33	7	complication	complication	NOUN
bionys-549	33	8	of	of	ADP
bionys-549	33	9	diabetes	diabete	NOUN
bionys-549	33	10	attributed	attribute	VERB
bionys-549	33	11	to	to	ADP
bionys-549	33	12	the	the	DET
bionys-549	33	13	failure	failure	NOUN
bionys-549	33	14	of	of	ADP
bionys-549	33	15	peripheral	peripheral	ADJ
bionys-549	33	16	nerves	nerve	NOUN
bionys-549	33	17	and	and	CCONJ
bionys-549	33	18	reduction	reduction	NOUN
bionys-549	33	19	in	in	ADP
bionys-549	33	20	myelinated	myelinated	ADJ
bionys-549	33	21	nerve	nerve	NOUN
bionys-549	33	22	fiber	fiber	NOUN
bionys-549	33	23	density	density	NOUN
bionys-549	33	24	.	.	PUNCT
bionys-549	34	1	diabetes	diabetes	NOUN
bionys-549	34	2	treatment	treatment	NOUN
bionys-549	34	3	using	use	VERB
bionys-549	34	4	herbal	herbal	ADJ
bionys-549	34	5	medicine	medicine	NOUN
bionys-549	34	6	has	have	AUX
bionys-549	34	7	been	be	AUX
bionys-549	34	8	explored	explore	VERB
bionys-549	34	9	and	and	CCONJ
bionys-549	34	10	natural	natural	ADJ
bionys-549	34	11	flavonoids	flavonoid	NOUN
bionys-549	34	12	such	such	ADJ
bionys-549	34	13	as	as	ADP
bionys-549	34	14	quercetin	quercetin	NOUN
bionys-549	34	15	find	find	VERB
bionys-549	34	16	use	use	NOUN
bionys-549	34	17	in	in	ADP
bionys-549	34	18	treating	treat	VERB
bionys-549	34	19	diabetes	diabetes	NOUN
bionys-549	34	20	,	,	PUNCT
bionys-549	34	21	as	as	SCONJ
bionys-549	34	22	revealed	reveal	VERB
bionys-549	34	23	by	by	ADP
bionys-549	34	24	several	several	ADJ
bionys-549	34	25	studies	study	NOUN
bionys-549	34	26	(	(	PUNCT
bionys-549	34	27	yagihashi	yagihashi	PROPN
bionys-549	34	28	et	et	PROPN
bionys-549	34	29	al	al	PROPN
bionys-549	34	30	.	.	PROPN
bionys-549	34	31	,	,	PUNCT
bionys-549	34	32	2011	2011	NUM
bionys-549	34	33	;	;	PUNCT
bionys-549	34	34	madić	madić	ADV
bionys-549	34	35	et	et	PROPN
bionys-549	34	36	al	al	PROPN
bionys-549	34	37	.	.	PROPN
bionys-549	34	38	,	,	PUNCT
bionys-549	34	39	2017	2017	NUM
bionys-549	34	40	;	;	PUNCT
bionys-549	34	41	jensen	jensen	PROPN
bionys-549	34	42	et	et	PROPN
bionys-549	34	43	al	al	PROPN
bionys-549	34	44	.	.	PROPN
bionys-549	34	45	,	,	PUNCT
bionys-549	34	46	2021	2021	NUM
bionys-549	34	47	)	)	PUNCT
bionys-549	34	48	.	.	PUNCT
bionys-549	35	1	it	it	PRON
bionys-549	35	2	also	also	ADV
bionys-549	35	3	depicts	depict	VERB
bionys-549	35	4	other	other	ADJ
bionys-549	35	5	symptoms	symptom	NOUN
bionys-549	35	6	such	such	ADJ
bionys-549	35	7	as	as	ADP
bionys-549	35	8	nerve	nerve	NOUN
bionys-549	35	9	pinch	pinch	NOUN
bionys-549	35	10	,	,	PUNCT
bionys-549	35	11	prolonged	prolonged	ADJ
bionys-549	35	12	pain	pain	NOUN
bionys-549	35	13	and	and	CCONJ
bionys-549	35	14	loss	loss	NOUN
bionys-549	35	15	of	of	ADP
bionys-549	35	16	sensitivity	sensitivity	NOUN
bionys-549	35	17	(	(	PUNCT
bionys-549	35	18	gronda	gronda	NOUN
bionys-549	35	19	et	et	PROPN
bionys-549	35	20	al	al	PROPN
bionys-549	35	21	.	.	PROPN
bionys-549	35	22	,	,	PUNCT
bionys-549	35	23	2020	2020	NUM
bionys-549	35	24	)	)	PUNCT
bionys-549	35	25	.	.	PUNCT
bionys-549	36	1	this	this	DET
bionys-549	36	2	disorder	disorder	NOUN
bionys-549	36	3	strikes	strike	VERB
bionys-549	36	4	the	the	DET
bionys-549	36	5	peripheral	peripheral	ADJ
bionys-549	36	6	nerves	nerve	NOUN
bionys-549	36	7	that	that	PRON
bionys-549	36	8	are	be	AUX
bionys-549	36	9	present	present	ADJ
bionys-549	36	10	outside	outside	ADP
bionys-549	36	11	the	the	DET
bionys-549	36	12	brain	brain	NOUN
bionys-549	36	13	,	,	PUNCT
bionys-549	36	14	at	at	ADP
bionys-549	36	15	the	the	DET
bionys-549	36	16	terminals	terminal	NOUN
bionys-549	36	17	of	of	ADP
bionys-549	36	18	the	the	DET
bionys-549	36	19	spinal	spinal	ADJ
bionys-549	36	20	cord	cord	NOUN
bionys-549	36	21	.	.	PUNCT
bionys-549	37	1	they	they	PRON
bionys-549	37	2	disrupt	disrupt	VERB
bionys-549	37	3	the	the	DET
bionys-549	37	4	nerve	nerve	NOUN
bionys-549	37	5	conduction	conduction	NOUN
bionys-549	37	6	mechanism	mechanism	NOUN
bionys-549	37	7	in	in	ADP
bionys-549	37	8	these	these	DET
bionys-549	37	9	peripheral	peripheral	ADJ
bionys-549	37	10	nerves	nerve	NOUN
bionys-549	37	11	.	.	PUNCT
bionys-549	38	1	in	in	ADP
bionys-549	38	2	fact	fact	NOUN
bionys-549	38	3	,	,	PUNCT
bionys-549	38	4	the	the	DET
bionys-549	38	5	prevalence	prevalence	NOUN
bionys-549	38	6	of	of	ADP
bionys-549	38	7	diabetic	diabetic	ADJ
bionys-549	38	8	neuropathy	neuropathy	ADJ
bionys-549	38	9	is	be	AUX
bionys-549	38	10	7	7	NUM
bionys-549	38	11	%	%	NOUN
bionys-549	38	12	in	in	ADP
bionys-549	38	13	the	the	DET
bionys-549	38	14	first	first	ADJ
bionys-549	38	15	year	year	NOUN
bionys-549	38	16	of	of	ADP
bionys-549	38	17	diagnosis	diagnosis	NOUN
bionys-549	38	18	reaching	reach	VERB
bionys-549	38	19	up	up	ADP
bionys-549	38	20	to	to	PART
bionys-549	38	21	50	50	NUM
bionys-549	38	22	%	%	NOUN
bionys-549	38	23	for	for	ADP
bionys-549	38	24	those	those	PRON
bionys-549	38	25	with	with	ADP
bionys-549	38	26	more	more	ADJ
bionys-549	38	27	than	than	ADP
bionys-549	38	28	25	25	NUM
bionys-549	38	29	years	year	NOUN
bionys-549	38	30	(	(	PUNCT
bionys-549	38	31	singh	singh	PROPN
bionys-549	38	32	et	et	PROPN
bionys-549	38	33	al	al	PROPN
bionys-549	38	34	.	.	PROPN
bionys-549	38	35	,	,	PUNCT
bionys-549	38	36	2021	2021	NUM
bionys-549	38	37	)	)	PUNCT
bionys-549	38	38	.	.	PUNCT
bionys-549	39	1	loss	loss	NOUN
bionys-549	39	2	of	of	ADP
bionys-549	39	3	sensation	sensation	NOUN
bionys-549	39	4	in	in	ADP
bionys-549	39	5	the	the	DET
bionys-549	39	6	lower	low	ADJ
bionys-549	39	7	limbs	limb	NOUN
bionys-549	39	8	causes	cause	VERB
bionys-549	39	9	limb	limb	ADJ
bionys-549	39	10	amputation	amputation	NOUN
bionys-549	39	11	in	in	ADP
bionys-549	39	12	1–2	1–2	NUM
bionys-549	39	13	%	%	NOUN
bionys-549	39	14	of	of	ADP
bionys-549	39	15	diabetic	diabetic	ADJ
bionys-549	39	16	patients	patient	NOUN
bionys-549	39	17	and	and	CCONJ
bionys-549	39	18	requires	require	VERB
bionys-549	39	19	high	high	ADJ
bionys-549	39	20	cost	cost	NOUN
bionys-549	39	21	of	of	ADP
bionys-549	39	22	treatment	treatment	NOUN
bionys-549	39	23	.	.	PUNCT
bionys-549	40	1	making	make	VERB
bionys-549	40	2	an	an	DET
bionys-549	40	3	early	early	ADJ
bionys-549	40	4	diagnosis	diagnosis	NOUN
bionys-549	40	5	and	and	CCONJ
bionys-549	40	6	managing	manage	VERB
bionys-549	40	7	diabetic	diabetic	ADJ
bionys-549	40	8	neuropathy	neuropathy	ADJ
bionys-549	40	9	are	be	AUX
bionys-549	40	10	challenging	challenge	VERB
bionys-549	40	11	,	,	PUNCT
bionys-549	40	12	and	and	CCONJ
bionys-549	40	13	currently	currently	ADV
bionys-549	40	14	,	,	PUNCT
bionys-549	40	15	no	no	DET
bionys-549	40	16	cure	cure	NOUN
bionys-549	40	17	is	be	AUX
bionys-549	40	18	available	available	ADJ
bionys-549	40	19	.	.	PUNCT
bionys-549	41	1	the	the	DET
bionys-549	41	2	polyol	polyol	PROPN
bionys-549	41	3	pathway	pathway	NOUN
bionys-549	41	4	converts	convert	VERB
bionys-549	41	5	glucose	glucose	NOUN
bionys-549	41	6	to	to	PART
bionys-549	41	7	sorbitol	sorbitol	VERB
bionys-549	41	8	by	by	ADP
bionys-549	41	9	reduction	reduction	NOUN
bionys-549	41	10	through	through	ADP
bionys-549	41	11	enzyme	enzyme	NOUN
bionys-549	41	12	aldose	aldose	ADJ
bionys-549	41	13	reductase	reductase	NOUN
bionys-549	41	14	which	which	PRON
bionys-549	41	15	is	be	AUX
bionys-549	41	16	the	the	DET
bionys-549	41	17	key	key	ADJ
bionys-549	41	18	factor	factor	NOUN
bionys-549	41	19	behind	behind	ADP
bionys-549	41	20	this	this	DET
bionys-549	41	21	complication	complication	NOUN
bionys-549	41	22	of	of	ADP
bionys-549	41	23	diabetes	diabetes	NOUN
bionys-549	41	24	.	.	PUNCT
bionys-549	42	1	aldehyde	aldehyde	NOUN
bionys-549	42	2	reductase	reductase	NOUN
bionys-549	42	3	comes	come	VERB
bionys-549	42	4	under	under	ADP
bionys-549	42	5	the	the	DET
bionys-549	42	6	family	family	NOUN
bionys-549	42	7	of	of	ADP
bionys-549	42	8	oxidoreductases	oxidoreductase	NOUN
bionys-549	42	9	.	.	PUNCT
bionys-549	43	1	under	under	ADP
bionys-549	43	2	normal	normal	ADJ
bionys-549	43	3	conditions	condition	NOUN
bionys-549	43	4	,	,	PUNCT
bionys-549	43	5	aldose	aldose	DET
bionys-549	43	6	reductase	reductase	NOUN
bionys-549	43	7	enzyme	enzyme	NOUN
bionys-549	43	8	does	do	AUX
bionys-549	43	9	n’t	not	PART
bionys-549	43	10	show	show	VERB
bionys-549	43	11	significant	significant	ADJ
bionys-549	43	12	affinity	affinity	NOUN
bionys-549	43	13	in	in	ADP
bionys-549	43	14	binding	bind	VERB
bionys-549	43	15	to	to	ADP
bionys-549	43	16	glucose	glucose	NOUN
bionys-549	43	17	.	.	PUNCT
bionys-549	44	1	on	on	ADP
bionys-549	44	2	the	the	DET
bionys-549	44	3	other	other	ADJ
bionys-549	44	4	hand	hand	NOUN
bionys-549	44	5	,	,	PUNCT
bionys-549	44	6	under	under	ADP
bionys-549	44	7	high	high	ADJ
bionys-549	44	8	blood	blood	NOUN
bionys-549	44	9	sugar	sugar	NOUN
bionys-549	44	10	conditions	condition	NOUN
bionys-549	44	11	,	,	PUNCT
bionys-549	44	12	the	the	DET
bionys-549	44	13	amount	amount	NOUN
bionys-549	44	14	of	of	ADP
bionys-549	44	15	glucose	glucose	NOUN
bionys-549	44	16	retained	retain	VERB
bionys-549	44	17	in	in	ADP
bionys-549	44	18	the	the	DET
bionys-549	44	19	system	system	NOUN
bionys-549	44	20	without	without	ADP
bionys-549	44	21	being	be	AUX
bionys-549	44	22	converted	convert	VERB
bionys-549	44	23	into	into	ADP
bionys-549	44	24	energy	energy	NOUN
bionys-549	44	25	increases	increase	NOUN
bionys-549	44	26	.	.	PUNCT
bionys-549	45	1	such	such	ADJ
bionys-549	45	2	left	leave	VERB
bionys-549	45	3	out	out	ADP
bionys-549	45	4	volumes	volume	NOUN
bionys-549	45	5	of	of	ADP
bionys-549	45	6	glucose	glucose	NOUN
bionys-549	45	7	easily	easily	ADV
bionys-549	45	8	pass	pass	VERB
bionys-549	45	9	through	through	ADP
bionys-549	45	10	the	the	DET
bionys-549	45	11	membranes	membrane	NOUN
bionys-549	45	12	of	of	ADP
bionys-549	45	13	nerve	nerve	NOUN
bionys-549	45	14	cells	cell	NOUN
bionys-549	45	15	,	,	PUNCT
bionys-549	45	16	kidney	kidney	NOUN
bionys-549	45	17	cells	cell	NOUN
bionys-549	45	18	and	and	CCONJ
bionys-549	45	19	retinal	retinal	ADJ
bionys-549	45	20	cells	cell	NOUN
bionys-549	45	21	.	.	PUNCT
bionys-549	46	1	after	after	ADP
bionys-549	46	2	entrance	entrance	NOUN
bionys-549	46	3	,	,	PUNCT
bionys-549	46	4	they	they	PRON
bionys-549	46	5	bind	bind	VERB
bionys-549	46	6	to	to	ADP
bionys-549	46	7	aldose	aldose	DET
bionys-549	46	8	reductase	reductase	NOUN
bionys-549	46	9	,	,	PUNCT
bionys-549	46	10	as	as	SCONJ
bionys-549	46	11	it	it	PRON
bionys-549	46	12	has	have	VERB
bionys-549	46	13	a	a	DET
bionys-549	46	14	higher	high	ADJ
bionys-549	46	15	affinity	affinity	NOUN
bionys-549	46	16	for	for	ADP
bionys-549	46	17	them	they	PRON
bionys-549	46	18	under	under	ADP
bionys-549	46	19	such	such	ADJ
bionys-549	46	20	conditions	condition	NOUN
bionys-549	46	21	(	(	PUNCT
bionys-549	46	22	twarda	twarda	NOUN
bionys-549	46	23	-	-	PUNCT
bionys-549	46	24	clapa	clapa	VERB
bionys-549	46	25	et	et	PROPN
bionys-549	46	26	al	al	PROPN
bionys-549	46	27	.	.	PROPN
bionys-549	46	28	,	,	PUNCT
bionys-549	46	29	2022	2022	NUM
bionys-549	46	30	)	)	PUNCT
bionys-549	46	31	.	.	PUNCT
bionys-549	47	1	this	this	PRON
bionys-549	47	2	does	do	AUX
bionys-549	47	3	n’t	not	PART
bionys-549	47	4	mean	mean	VERB
bionys-549	47	5	that	that	SCONJ
bionys-549	47	6	the	the	DET
bionys-549	47	7	normal	normal	ADJ
bionys-549	47	8	energy	energy	NOUN
bionys-549	47	9	conversion	conversion	NOUN
bionys-549	47	10	process	process	NOUN
bionys-549	47	11	wo	will	AUX
bionys-549	47	12	n’t	not	PART
bionys-549	47	13	take	take	VERB
bionys-549	47	14	place	place	NOUN
bionys-549	47	15	,	,	PUNCT
bionys-549	47	16	but	but	CCONJ
bionys-549	47	17	the	the	DET
bionys-549	47	18	glucose	glucose	NOUN
bionys-549	47	19	being	be	AUX
bionys-549	47	20	released	release	VERB
bionys-549	47	21	in	in	ADP
bionys-549	47	22	larger	large	ADJ
bionys-549	47	23	volumes	volume	NOUN
bionys-549	47	24	can	can	AUX
bionys-549	47	25	not	not	PART
bionys-549	47	26	be	be	AUX
bionys-549	47	27	incorporated	incorporate	VERB
bionys-549	47	28	into	into	ADP
bionys-549	47	29	the	the	DET
bionys-549	47	30	normal	normal	ADJ
bionys-549	47	31	process	process	NOUN
bionys-549	47	32	of	of	ADP
bionys-549	47	33	energy	energy	NOUN
bionys-549	47	34	conversion	conversion	NOUN
bionys-549	47	35	and	and	CCONJ
bionys-549	47	36	moves	move	NOUN
bionys-549	47	37	into	into	ADP
bionys-549	47	38	the	the	DET
bionys-549	47	39	next	next	ADJ
bionys-549	47	40	possible	possible	ADJ
bionys-549	47	41	process	process	NOUN
bionys-549	47	42	,	,	PUNCT
bionys-549	47	43	here	here	ADV
bionys-549	47	44	being	be	AUX
bionys-549	47	45	the	the	DET
bionys-549	47	46	polyol	polyol	NOUN
bionys-549	47	47	pathway	pathway	NOUN
bionys-549	47	48	.	.	PUNCT
bionys-549	48	1	diabetic	diabetic	ADJ
bionys-549	48	2	neuropathy	neuropathy	ADJ
bionys-549	48	3	is	be	AUX
bionys-549	48	4	a	a	DET
bionys-549	48	5	complication	complication	NOUN
bionys-549	48	6	associated	associate	VERB
bionys-549	48	7	with	with	ADP
bionys-549	48	8	diabetes	diabetes	NOUN
bionys-549	48	9	caused	cause	VERB
bionys-549	48	10	by	by	ADP
bionys-549	48	11	an	an	DET
bionys-549	48	12	increase	increase	NOUN
bionys-549	48	13	in	in	ADP
bionys-549	48	14	glucose	glucose	NOUN
bionys-549	48	15	flux	flux	NOUN
bionys-549	48	16	under	under	ADP
bionys-549	48	17	hyperglycemic	hyperglycemic	ADJ
bionys-549	48	18	conditions	condition	NOUN
bionys-549	48	19	leading	lead	VERB
bionys-549	48	20	to	to	ADP
bionys-549	48	21	the	the	DET
bionys-549	48	22	accumulation	accumulation	NOUN
bionys-549	48	23	of	of	ADP
bionys-549	48	24	sorbitol	sorbitol	NOUN
bionys-549	48	25	in	in	ADP
bionys-549	48	26	nerve	nerve	NOUN
bionys-549	48	27	cells	cell	NOUN
bionys-549	48	28	(	(	PUNCT
bionys-549	48	29	goto	goto	NOUN
bionys-549	48	30	et	et	PROPN
bionys-549	48	31	al	al	PROPN
bionys-549	48	32	.	.	PROPN
bionys-549	48	33	,	,	PUNCT
bionys-549	48	34	1995	1995	NUM
bionys-549	48	35	)	)	PUNCT
bionys-549	48	36	.	.	PUNCT
bionys-549	49	1	this	this	PRON
bionys-549	49	2	causes	cause	VERB
bionys-549	49	3	reduced	reduce	VERB
bionys-549	49	4	myo	myo	NOUN
bionys-549	49	5	-	-	PUNCT
bionys-549	49	6	inositol	inositol	NOUN
bionys-549	49	7	production	production	NOUN
bionys-549	49	8	(	(	PUNCT
bionys-549	49	9	goto	goto	NOUN
bionys-549	49	10	et	et	PROPN
bionys-549	49	11	al	al	PROPN
bionys-549	49	12	.	.	PROPN
bionys-549	49	13	,	,	PUNCT
bionys-549	49	14	1995	1995	NUM
bionys-549	49	15	)	)	PUNCT
bionys-549	49	16	in	in	ADP
bionys-549	49	17	addition	addition	NOUN
bionys-549	49	18	to	to	ADP
bionys-549	49	19	inducing	induce	VERB
bionys-549	49	20	the	the	DET
bionys-549	49	21	production	production	NOUN
bionys-549	49	22	of	of	ADP
bionys-549	49	23	advanced	advanced	ADJ
bionys-549	49	24	glycation	glycation	NOUN
bionys-549	49	25	end	end	NOUN
bionys-549	49	26	products	product	NOUN
bionys-549	49	27	(	(	PUNCT
bionys-549	49	28	age	age	NOUN
bionys-549	49	29	’s	’s	PART
bionys-549	49	30	)	)	PUNCT
bionys-549	49	31	.	.	PUNCT
bionys-549	50	1	the	the	DET
bionys-549	50	2	anionic	anionic	ADJ
bionys-549	50	3	region	region	NOUN
bionys-549	50	4	of	of	ADP
bionys-549	50	5	the	the	DET
bionys-549	50	6	active	active	ADJ
bionys-549	50	7	site	site	NOUN
bionys-549	50	8	has	have	VERB
bionys-549	50	9	residues	residue	NOUN
bionys-549	50	10	his110	his110	NOUN
bionys-549	50	11	and	and	CCONJ
bionys-549	50	12	tyr48	tyr48	VERB
bionys-549	50	13	that	that	PRON
bionys-549	50	14	are	be	AUX
bionys-549	50	15	involved	involve	VERB
bionys-549	50	16	in	in	ADP
bionys-549	50	17	the	the	DET
bionys-549	50	18	much	much	ADV
bionys-549	50	19	important	important	ADJ
bionys-549	50	20	detoxification	detoxification	NOUN
bionys-549	50	21	mechanism	mechanism	NOUN
bionys-549	50	22	(	(	PUNCT
bionys-549	50	23	klebe	klebe	VERB
bionys-549	50	24	et	et	PROPN
bionys-549	50	25	al	al	PROPN
bionys-549	50	26	.	.	PROPN
bionys-549	50	27	,	,	PUNCT
bionys-549	50	28	2004	2004	NUM
bionys-549	50	29	)	)	PUNCT
bionys-549	50	30	wherein	wherein	SCONJ
bionys-549	50	31	methylglyoxal	methylglyoxal	NOUN
bionys-549	50	32	and	and	CCONJ
bionys-549	50	33	3	3	NUM
bionys-549	50	34	-	-	PUNCT
bionys-549	50	35	deoxyglucosone	deoxyglucosone	NOUN
bionys-549	50	36	are	be	AUX
bionys-549	50	37	reduced	reduce	VERB
bionys-549	50	38	to	to	PART
bionys-549	50	39	curb	curb	VERB
bionys-549	50	40	toxicity	toxicity	NOUN
bionys-549	50	41	.	.	PUNCT
bionys-549	51	1	several	several	ADJ
bionys-549	51	2	aldose	aldose	ADJ
bionys-549	51	3	reductase	reductase	NOUN
bionys-549	51	4	inhibitors	inhibitor	NOUN
bionys-549	51	5	(	(	PUNCT
bionys-549	51	6	ari	ari	PROPN
bionys-549	51	7	)	)	PUNCT
bionys-549	51	8	emerged	emerge	VERB
bionys-549	51	9	,	,	PUNCT
bionys-549	51	10	but	but	CCONJ
bionys-549	51	11	not	not	PART
bionys-549	51	12	successful	successful	ADJ
bionys-549	51	13	at	at	ADP
bionys-549	51	14	clinical	clinical	ADJ
bionys-549	51	15	owing	owe	VERB
bionys-549	51	16	to	to	ADP
bionys-549	51	17	the	the	DET
bionys-549	51	18	adverse	adverse	ADJ
bionys-549	51	19	effects	effect	NOUN
bionys-549	51	20	or	or	CCONJ
bionys-549	51	21	inferior	inferior	ADJ
bionys-549	51	22	efficacies	efficacy	NOUN
bionys-549	51	23	.	.	PUNCT
bionys-549	52	1	epalrestat	epalrestat	NOUN
bionys-549	52	2	,	,	PUNCT
bionys-549	52	3	licensed	license	VERB
bionys-549	52	4	in	in	ADP
bionys-549	52	5	japan	japan	PROPN
bionys-549	52	6	is	be	AUX
bionys-549	52	7	the	the	DET
bionys-549	52	8	single	single	ADJ
bionys-549	52	9	drug	drug	NOUN
bionys-549	52	10	of	of	ADP
bionys-549	52	11	this	this	DET
bionys-549	52	12	category	category	NOUN
bionys-549	52	13	(	(	PUNCT
bionys-549	52	14	kumar	kumar	PROPN
bionys-549	52	15	et	et	PROPN
bionys-549	52	16	al	al	PROPN
bionys-549	52	17	.	.	PROPN
bionys-549	52	18	,	,	PUNCT
bionys-549	52	19	2012	2012	NUM
bionys-549	52	20	)	)	PUNCT
bionys-549	52	21	.	.	PUNCT
bionys-549	53	1	aldose	aldose	PROPN
bionys-549	53	2	reductase	reductase	NOUN
bionys-549	53	3	carries	carry	VERB
bionys-549	53	4	out	out	ADP
bionys-549	53	5	a	a	DET
bionys-549	53	6	process	process	NOUN
bionys-549	53	7	of	of	ADP
bionys-549	53	8	detoxifying	detoxify	VERB
bionys-549	53	9	the	the	DET
bionys-549	53	10	toxic	toxic	ADJ
bionys-549	53	11	aldehydes	aldehyde	NOUN
bionys-549	53	12	.	.	PUNCT
bionys-549	54	1	all	all	DET
bionys-549	54	2	the	the	DET
bionys-549	54	3	synthetic	synthetic	ADJ
bionys-549	54	4	and	and	CCONJ
bionys-549	54	5	natural	natural	ADJ
bionys-549	54	6	inhibitors	inhibitor	NOUN
bionys-549	54	7	studied	study	VERB
bionys-549	54	8	so	so	ADV
bionys-549	54	9	far	far	ADV
bionys-549	54	10	interfere	interfere	VERB
bionys-549	54	11	with	with	ADP
bionys-549	54	12	the	the	DET
bionys-549	54	13	detoxification	detoxification	NOUN
bionys-549	54	14	mechanism	mechanism	NOUN
bionys-549	54	15	by	by	ADP
bionys-549	54	16	occupying	occupy	VERB
bionys-549	54	17	that	that	DET
bionys-549	54	18	region	region	NOUN
bionys-549	54	19	or	or	CCONJ
bionys-549	54	20	binding	bind	VERB
bionys-549	54	21	to	to	ADP
bionys-549	54	22	residues	residue	NOUN
bionys-549	54	23	trp111	trp111	PROPN
bionys-549	54	24	,	,	PUNCT
bionys-549	54	25	his110	his110	NOUN
bionys-549	54	26	,	,	PUNCT
bionys-549	54	27	and	and	CCONJ
bionys-549	54	28	tyr48	tyr48	VERB
bionys-549	54	29	(	(	PUNCT
bionys-549	54	30	imran	imran	PROPN
bionys-549	54	31	et	et	PROPN
bionys-549	54	32	al	al	PROPN
bionys-549	54	33	.	.	PROPN
bionys-549	54	34	,	,	PUNCT
bionys-549	54	35	2022	2022	NUM
bionys-549	54	36	)	)	PUNCT
bionys-549	54	37	.	.	PUNCT
bionys-549	55	1	this	this	DET
bionys-549	55	2	inner	inner	ADJ
bionys-549	55	3	anionic	anionic	ADJ
bionys-549	55	4	region	region	NOUN
bionys-549	55	5	of	of	ADP
bionys-549	55	6	the	the	DET
bionys-549	55	7	active	active	ADJ
bionys-549	55	8	site	site	NOUN
bionys-549	55	9	generally	generally	ADV
bionys-549	55	10	carries	carry	VERB
bionys-549	55	11	out	out	ADP
bionys-549	55	12	this	this	DET
bionys-549	55	13	process	process	NOUN
bionys-549	55	14	of	of	ADP
bionys-549	55	15	detoxification	detoxification	NOUN
bionys-549	55	16	by	by	ADP
bionys-549	55	17	binding	bind	VERB
bionys-549	55	18	to	to	ADP
bionys-549	55	19	toxic	toxic	ADJ
bionys-549	55	20	aldehydes	aldehyde	NOUN
bionys-549	55	21	(	(	PUNCT
bionys-549	55	22	sulaiman	sulaiman	PROPN
bionys-549	55	23	et	et	PROPN
bionys-549	55	24	al	al	PROPN
bionys-549	55	25	.	.	PROPN
bionys-549	55	26	,	,	PUNCT
bionys-549	55	27	2022	2022	NUM
bionys-549	55	28	)	)	PUNCT
bionys-549	55	29	.	.	PUNCT
bionys-549	56	1	when	when	SCONJ
bionys-549	56	2	this	this	DET
bionys-549	56	3	process	process	NOUN
bionys-549	56	4	is	be	AUX
bionys-549	56	5	affected	affect	VERB
bionys-549	56	6	,	,	PUNCT
bionys-549	56	7	toxic	toxic	ADJ
bionys-549	56	8	aldehydes	aldehyde	NOUN
bionys-549	56	9	in	in	ADP
bionys-549	56	10	the	the	DET
bionys-549	56	11	system	system	NOUN
bionys-549	56	12	glycate	glycate	VERB
bionys-549	56	13	the	the	DET
bionys-549	56	14	nitrogen	nitrogen	NOUN
bionys-549	56	15	on	on	ADP
bionys-549	56	16	collagen	collagen	NOUN
bionys-549	56	17	-	-	PUNCT
bionys-549	56	18	like	like	ADJ
bionys-549	56	19	proteins	protein	NOUN
bionys-549	56	20	,	,	PUNCT
bionys-549	56	21	forming	form	VERB
bionys-549	56	22	ages	age	NOUN
bionys-549	56	23	,	,	PUNCT
bionys-549	56	24	which	which	PRON
bionys-549	56	25	contribute	contribute	VERB
bionys-549	56	26	to	to	ADP
bionys-549	56	27	diabetic	diabetic	ADJ
bionys-549	56	28	complications	complication	NOUN
bionys-549	56	29	such	such	ADJ
bionys-549	56	30	as	as	ADP
bionys-549	56	31	peripheral	peripheral	ADJ
bionys-549	56	32	neuropathy	neuropathy	ADJ
bionys-549	56	33	,	,	PUNCT
bionys-549	56	34	diabetic	diabetic	ADJ
bionys-549	56	35	nephropathy	nephropathy	NOUN
bionys-549	56	36	,	,	PUNCT
bionys-549	56	37	and	and	CCONJ
bionys-549	56	38	diabetic	diabetic	ADJ
bionys-549	56	39	angiopathy	angiopathy	ADJ
bionys-549	56	40	.	.	PUNCT
bionys-549	57	1	therefore	therefore	ADV
bionys-549	57	2	,	,	PUNCT
bionys-549	57	3	finding	find	VERB
bionys-549	57	4	a	a	DET
bionys-549	57	5	drug	drug	NOUN
bionys-549	57	6	that	that	PRON
bionys-549	57	7	would	would	AUX
bionys-549	57	8	focus	focus	VERB
bionys-549	57	9	on	on	ADP
bionys-549	57	10	selective	selective	ADJ
bionys-549	57	11	inhibition	inhibition	NOUN
bionys-549	57	12	of	of	ADP
bionys-549	57	13	aldose	aldose	DET
bionys-549	57	14	reductase	reductase	NOUN
bionys-549	57	15	binding	bind	VERB
bionys-549	57	16	to	to	ADP
bionys-549	57	17	glucose	glucose	NOUN
bionys-549	57	18	without	without	ADP
bionys-549	57	19	affecting	affect	VERB
bionys-549	57	20	the	the	DET
bionys-549	57	21	detoxification	detoxification	NOUN
bionys-549	57	22	mechanism	mechanism	NOUN
bionys-549	57	23	would	would	AUX
bionys-549	57	24	prove	prove	VERB
bionys-549	57	25	a	a	DET
bionys-549	57	26	good	good	ADJ
bionys-549	57	27	solution	solution	NOUN
bionys-549	57	28	.	.	PUNCT
bionys-549	58	1	the	the	DET
bionys-549	58	2	detoxification	detoxification	NOUN
bionys-549	58	3	mechanism	mechanism	NOUN
bionys-549	58	4	is	be	AUX
bionys-549	58	5	a	a	DET
bionys-549	58	6	vital	vital	ADJ
bionys-549	58	7	phenomenon	phenomenon	NOUN
bionys-549	58	8	that	that	PRON
bionys-549	58	9	takes	take	VERB
bionys-549	58	10	place	place	NOUN
bionys-549	58	11	with	with	ADP
bionys-549	58	12	the	the	DET
bionys-549	58	13	assistance	assistance	NOUN
bionys-549	58	14	of	of	ADP
bionys-549	58	15	aldose	aldose	PRON
bionys-549	58	16	reductase	reductase	NOUN
bionys-549	58	17	enzyme	enzyme	NOUN
bionys-549	58	18	,	,	PUNCT
bionys-549	58	19	where	where	SCONJ
bionys-549	58	20	the	the	DET
bionys-549	58	21	toxic	toxic	ADJ
bionys-549	58	22	aldehydes	aldehyde	NOUN
bionys-549	58	23	come	come	VERB
bionys-549	58	24	and	and	CCONJ
bionys-549	58	25	bind	bind	VERB
bionys-549	58	26	to	to	ADP
bionys-549	58	27	the	the	DET
bionys-549	58	28	residues	residue	NOUN
bionys-549	58	29	trp111	trp111	PROPN
bionys-549	58	30	,	,	PUNCT
bionys-549	58	31	his	his	PRON
bionys-549	58	32	110	110	NUM
bionys-549	58	33	,	,	PUNCT
bionys-549	58	34	tyr48	tyr48	VERB
bionys-549	58	35	present	present	ADJ
bionys-549	58	36	in	in	ADP
bionys-549	58	37	the	the	DET
bionys-549	58	38	inner	inner	ADJ
bionys-549	58	39	anionic	anionic	ADJ
bionys-549	58	40	region	region	NOUN
bionys-549	58	41	of	of	ADP
bionys-549	58	42	the	the	DET
bionys-549	58	43	active	active	ADJ
bionys-549	58	44	site	site	NOUN
bionys-549	58	45	.	.	PUNCT
bionys-549	59	1	glucose	glucose	NOUN
bionys-549	59	2	generally	generally	ADV
bionys-549	59	3	comes	come	VERB
bionys-549	59	4	in	in	ADP
bionys-549	59	5	and	and	CCONJ
bionys-549	59	6	binds	bind	VERB
bionys-549	59	7	to	to	ADP
bionys-549	59	8	the	the	DET
bionys-549	59	9	active	active	ADJ
bionys-549	59	10	site	site	NOUN
bionys-549	59	11	making	make	VERB
bionys-549	59	12	interactions	interaction	NOUN
bionys-549	59	13	with	with	ADP
bionys-549	59	14	tyr48	tyr48	NOUN
bionys-549	59	15	that	that	PRON
bionys-549	59	16	donates	donate	VERB
bionys-549	59	17	a	a	DET
bionys-549	59	18	proton	proton	NOUN
bionys-549	59	19	during	during	ADP
bionys-549	59	20	the	the	DET
bionys-549	59	21	reduction	reduction	NOUN
bionys-549	59	22	mechanism	mechanism	NOUN
bionys-549	59	23	(	(	PUNCT
bionys-549	59	24	chen	chen	PROPN
bionys-549	59	25	et	et	PROPN
bionys-549	59	26	al	al	PROPN
bionys-549	59	27	.	.	PROPN
bionys-549	59	28	,	,	PUNCT
bionys-549	59	29	2022	2022	NUM
bionys-549	59	30	)	)	PUNCT
bionys-549	59	31	.	.	PUNCT
bionys-549	60	1	therefore	therefore	ADV
bionys-549	60	2	,	,	PUNCT
bionys-549	60	3	finding	find	VERB
bionys-549	60	4	an	an	DET
bionys-549	60	5	inhibitor	inhibitor	NOUN
bionys-549	60	6	that	that	PRON
bionys-549	60	7	would	would	AUX
bionys-549	60	8	block	block	VERB
bionys-549	60	9	the	the	DET
bionys-549	60	10	entry	entry	NOUN
bionys-549	60	11	of	of	ADP
bionys-549	60	12	glucose	glucose	NOUN
bionys-549	60	13	(	(	PUNCT
bionys-549	60	14	a	a	DET
bionys-549	60	15	bulkier	bulky	ADJ
bionys-549	60	16	group	group	NOUN
bionys-549	60	17	)	)	PUNCT
bionys-549	60	18	while	while	SCONJ
bionys-549	60	19	allowing	allow	VERB
bionys-549	60	20	toxic	toxic	ADJ
bionys-549	60	21	aldehydes	aldehyde	NOUN
bionys-549	60	22	,	,	PUNCT
bionys-549	60	23	such	such	ADJ
bionys-549	60	24	as	as	ADP
bionys-549	60	25	methylglyoxal	methylglyoxal	ADJ
bionys-549	60	26	and	and	CCONJ
bionys-549	60	27	3	3	NUM
bionys-549	60	28	-	-	PUNCT
bionys-549	60	29	deoxyglucosone	deoxyglucosone	NOUN
bionys-549	60	30	(	(	PUNCT
bionys-549	60	31	three	three	NUM
bionys-549	60	32	-	-	PUNCT
bionys-549	60	33	carbon	carbon	NOUN
bionys-549	60	34	group	group	NOUN
bionys-549	60	35	compounds	compound	VERB
bionys-549	60	36	)	)	PUNCT
bionys-549	60	37	,	,	PUNCT
bionys-549	60	38	to	to	PART
bionys-549	60	39	enter	enter	VERB
bionys-549	60	40	the	the	DET
bionys-549	60	41	pocket	pocket	NOUN
bionys-549	60	42	helps	help	VERB
bionys-549	60	43	us	we	PRON
bionys-549	60	44	eliminate	eliminate	VERB
bionys-549	60	45	the	the	DET
bionys-549	60	46	reduction	reduction	NOUN
bionys-549	60	47	of	of	ADP
bionys-549	60	48	glucose	glucose	NOUN
bionys-549	60	49	to	to	PART
bionys-549	60	50	sorbitol	sorbitol	VERB
bionys-549	60	51	and	and	CCONJ
bionys-549	60	52	does	do	AUX
bionys-549	60	53	not	not	PART
bionys-549	60	54	affect	affect	VERB
bionys-549	60	55	the	the	DET
bionys-549	60	56	detoxification	detoxification	NOUN
bionys-549	60	57	mechanism	mechanism	NOUN
bionys-549	60	58	.	.	PUNCT
bionys-549	61	1	sulaiman	sulaiman	PROPN
bionys-549	61	2	et	et	PROPN
bionys-549	61	3	al	al	PROPN
bionys-549	61	4	.	.	PROPN
bionys-549	62	1	(	(	PUNCT
bionys-549	62	2	2022	2022	NUM
bionys-549	62	3	)	)	PUNCT
bionys-549	62	4	reported	report	VERB
bionys-549	62	5	the	the	DET
bionys-549	62	6	presence	presence	NOUN
bionys-549	62	7	of	of	ADP
bionys-549	62	8	markers	marker	NOUN
bionys-549	62	9	related	relate	VERB
bionys-549	62	10	to	to	ADP
bionys-549	62	11	antioxidant	antioxidant	ADJ
bionys-549	62	12	property	property	NOUN
bionys-549	62	13	and	and	CCONJ
bionys-549	62	14	carbonic	carbonic	ADJ
bionys-549	62	15	anhydrase	anhydrase	NOUN
bionys-549	62	16	level	level	NOUN
bionys-549	62	17	in	in	ADP
bionys-549	62	18	correlation	correlation	NOUN
bionys-549	62	19	with	with	ADP
bionys-549	62	20	diabetes	diabetes	NOUN
bionys-549	62	21	complications	complication	NOUN
bionys-549	62	22	(	(	PUNCT
bionys-549	62	23	chen	chen	PROPN
bionys-549	62	24	et	et	PROPN
bionys-549	62	25	al	al	PROPN
bionys-549	62	26	.	.	PROPN
bionys-549	62	27	,	,	PUNCT
bionys-549	62	28	2022	2022	NUM
bionys-549	62	29	)	)	PUNCT
bionys-549	62	30	.	.	PUNCT
bionys-549	63	1	advanced	advanced	ADJ
bionys-549	63	2	glycation	glycation	NOUN
bionys-549	63	3	end	end	NOUN
bionys-549	63	4	products	product	NOUN
bionys-549	63	5	were	be	AUX
bionys-549	63	6	related	relate	VERB
bionys-549	63	7	to	to	ADP
bionys-549	63	8	molecular	molecular	ADJ
bionys-549	63	9	mechanisms	mechanism	NOUN
bionys-549	63	10	underlying	underlie	VERB
bionys-549	63	11	the	the	DET
bionys-549	63	12	skin	skin	NOUN
bionys-549	63	13	fibroblast	fibroblast	ADJ
bionys-549	63	14	growth	growth	NOUN
bionys-549	63	15	parameters	parameter	NOUN
bionys-549	63	16	(	(	PUNCT
bionys-549	63	17	ciccone	ciccone	PROPN
bionys-549	63	18	et	et	PROPN
bionys-549	63	19	al	al	PROPN
bionys-549	63	20	.	.	PROPN
bionys-549	63	21	,	,	PUNCT
bionys-549	63	22	2022	2022	NUM
bionys-549	63	23	)	)	PUNCT
bionys-549	63	24	.	.	PUNCT
bionys-549	64	1	antioxidant	antioxidant	ADJ
bionys-549	64	2	utility	utility	NOUN
bionys-549	64	3	in	in	ADP
bionys-549	64	4	combination	combination	NOUN
bionys-549	64	5	with	with	ADP
bionys-549	64	6	aldose	aldose	PRON
bionys-549	64	7	reductase	reductase	NOUN
bionys-549	64	8	inhibition	inhibition	NOUN
bionys-549	64	9	has	have	AUX
bionys-549	64	10	been	be	AUX
bionys-549	64	11	evaluated	evaluate	VERB
bionys-549	64	12	with	with	ADP
bionys-549	64	13	several	several	ADJ
bionys-549	64	14	benzaldoxime	benzaldoxime	ADJ
bionys-549	64	15	derivatives	derivative	NOUN
bionys-549	64	16	(	(	PUNCT
bionys-549	64	17	zhang	zhang	X
bionys-549	64	18	et	et	PROPN
bionys-549	64	19	al	al	PROPN
bionys-549	64	20	.	.	PROPN
bionys-549	64	21	,	,	PUNCT
bionys-549	64	22	2022	2022	NUM
bionys-549	64	23	)	)	PUNCT
bionys-549	64	24	.	.	PUNCT
bionys-549	65	1	the	the	DET
bionys-549	65	2	potential	potential	NOUN
bionys-549	65	3	of	of	ADP
bionys-549	65	4	aldose	aldose	PRON
bionys-549	65	5	reductase	reductase	NOUN
bionys-549	65	6	inhibitory	inhibitory	ADJ
bionys-549	65	7	activity	activity	NOUN
bionys-549	65	8	has	have	AUX
bionys-549	65	9	been	be	AUX
bionys-549	65	10	suggested	suggest	VERB
bionys-549	65	11	to	to	PART
bionys-549	65	12	improve	improve	VERB
bionys-549	65	13	treating	treat	VERB
bionys-549	65	14	injury	injury	NOUN
bionys-549	65	15	of	of	ADP
bionys-549	65	16	medulla	medulla	NOUN
bionys-549	65	17	spinalis	spinali	VERB
bionys-549	65	18	through	through	ADP
bionys-549	65	19	neuronal	neuronal	ADJ
bionys-549	65	20	differentiation	differentiation	NOUN
bionys-549	65	21	of	of	ADP
bionys-549	65	22	transplanted	transplanted	ADJ
bionys-549	65	23	nscs	nsc	NOUN
bionys-549	65	24	(	(	PUNCT
bionys-549	65	25	zheng	zheng	PROPN
bionys-549	65	26	et	et	PROPN
bionys-549	65	27	al	al	PROPN
bionys-549	65	28	.	.	PROPN
bionys-549	65	29	,	,	PUNCT
bionys-549	65	30	2021	2021	NUM
bionys-549	65	31	)	)	PUNCT
bionys-549	65	32	.	.	PUNCT
bionys-549	66	1	emodin	emodin	PROPN
bionys-549	66	2	has	have	AUX
bionys-549	66	3	been	be	AUX
bionys-549	66	4	evaluated	evaluate	VERB
bionys-549	66	5	as	as	ADP
bionys-549	66	6	a	a	DET
bionys-549	66	7	potential	potential	ADJ
bionys-549	66	8	candidate	candidate	NOUN
bionys-549	66	9	for	for	ADP
bionys-549	66	10	treating	treat	VERB
bionys-549	66	11	metabolic	metabolic	NOUN
bionys-549	66	12	diseases	disease	NOUN
bionys-549	66	13	through	through	ADP
bionys-549	66	14	its	its	PRON
bionys-549	66	15	multifaceted	multifaceted	ADJ
bionys-549	66	16	role	role	NOUN
bionys-549	66	17	in	in	ADP
bionys-549	66	18	inflammation	inflammation	NOUN
bionys-549	66	19	and	and	CCONJ
bionys-549	66	20	diabetes	diabetes	NOUN
bionys-549	66	21	(	(	PUNCT
bionys-549	66	22	saeed	saeed	PROPN
bionys-549	66	23	et	et	PROPN
bionys-549	66	24	al	al	PROPN
bionys-549	66	25	.	.	PROPN
bionys-549	66	26	,	,	PUNCT
bionys-549	66	27	2022	2022	NUM
bionys-549	66	28	)	)	PUNCT
bionys-549	66	29	.	.	PUNCT
bionys-549	67	1	these	these	DET
bionys-549	67	2	authors	author	NOUN
bionys-549	67	3	have	have	AUX
bionys-549	67	4	identified	identify	VERB
bionys-549	67	5	6	6	NUM
bionys-549	67	6	-	-	PUNCT
bionys-549	67	7	oxo-6,9	oxo-6,9	ADJ
bionys-549	67	8	-	-	PUNCT
bionys-549	67	9	dihydro1h	dihydro1h	NOUN
bionys-549	67	10	-	-	PUNCT
bionys-549	67	11	purin-8	purin-8	NUM
bionys-549	67	12	-	-	PUNCT
bionys-549	67	13	yl	yl	NOUN
bionys-549	67	14	)	)	PUNCT
bionys-549	67	15	thio	thio	NOUN
bionys-549	67	16	)	)	PUNCT
bionys-549	67	17	acetamide	acetamide	NOUN
bionys-549	67	18	as	as	ADP
bionys-549	67	19	potential	potential	ADJ
bionys-549	67	20	aldose	aldose	ADJ
bionys-549	67	21	reductase	reductase	NOUN
bionys-549	67	22	inhibitor	inhibitor	NOUN
bionys-549	67	23	through	through	ADP
bionys-549	67	24	pharmacophore	pharmacophore	NOUN
bionys-549	67	25	-	-	PUNCT
bionys-549	67	26	based	base	VERB
bionys-549	67	27	124	124	NUM
bionys-549	67	28	biologica	biologica	PROPN
bionys-549	67	29	nyssana	nyssana	PROPN
bionys-549	67	30	●	●	PUNCT
bionys-549	67	31	15	15	NUM
bionys-549	67	32	(	(	PUNCT
bionys-549	67	33	2	2	NUM
bionys-549	67	34	)	)	PUNCT
bionys-549	67	35	december	december	PROPN
bionys-549	67	36	2024	2024	NUM
bionys-549	67	37	:	:	PUNCT
bionys-549	67	38	nagarajan	nagarajan	NOUN
bionys-549	67	39	et	et	PROPN
bionys-549	67	40	al	al	PROPN
bionys-549	67	41	.	.	PUNCT
bionys-549	68	1	●	●	PUNCT
bionys-549	68	2	beyond	beyond	ADP
bionys-549	68	3	boundaries	boundary	NOUN
bionys-549	68	4	:	:	PUNCT
bionys-549	68	5	pioneering	pioneer	VERB
bionys-549	68	6	discoveries	discovery	NOUN
bionys-549	68	7	in	in	ADP
bionys-549	68	8	aldose	aldose	PRON
bionys-549	68	9	reductase	reductase	NOUN
bionys-549	68	10	inhibition	inhibition	NOUN
bionys-549	68	11	for	for	ADP
bionys-549	68	12	diabetic	diabetic	ADJ
bionys-549	68	13	neuropathy	neuropathy	ADJ
bionys-549	68	14	biologica	biologica	PROPN
bionys-549	68	15	nyssana	nyssana	PROPN
bionys-549	68	16	●	●	PUNCT
bionys-549	68	17	15	15	NUM
bionys-549	68	18	(	(	PUNCT
bionys-549	68	19	2	2	NUM
bionys-549	68	20	)	)	PUNCT
bionys-549	68	21	december	december	PROPN
bionys-549	68	22	2024	2024	NUM
bionys-549	68	23	:	:	PUNCT
bionys-549	68	24	nagarajan	nagarajan	NOUN
bionys-549	68	25	et	et	PROPN
bionys-549	68	26	al	al	PROPN
bionys-549	68	27	.	.	PUNCT
bionys-549	69	1	●	●	PUNCT
bionys-549	69	2	beyond	beyond	ADP
bionys-549	69	3	boundaries	boundary	NOUN
bionys-549	69	4	:	:	PUNCT
bionys-549	69	5	pioneering	pioneer	VERB
bionys-549	69	6	discoveries	discovery	NOUN
bionys-549	69	7	in	in	ADP
bionys-549	69	8	aldose	aldose	PRON
bionys-549	69	9	reductase	reductase	NOUN
bionys-549	69	10	inhibition	inhibition	NOUN
bionys-549	69	11	for	for	ADP
bionys-549	69	12	diabetic	diabetic	ADJ
bionys-549	69	13	neuropathy	neuropathy	ADJ
bionys-549	69	14	125	125	NUM
bionys-549	69	15	search	search	NOUN
bionys-549	69	16	in	in	ADP
bionys-549	69	17	nubbedb	nubbedb	NOUN
bionys-549	69	18	database	database	NOUN
bionys-549	69	19	(	(	PUNCT
bionys-549	69	20	bakal	bakal	PROPN
bionys-549	69	21	et	et	PROPN
bionys-549	69	22	al	al	PROPN
bionys-549	69	23	.	.	PROPN
bionys-549	69	24	,	,	PUNCT
bionys-549	69	25	2022	2022	NUM
bionys-549	69	26	)	)	PUNCT
bionys-549	69	27	.	.	PUNCT
bionys-549	70	1	using	use	VERB
bionys-549	70	2	molecular	molecular	ADJ
bionys-549	70	3	simulation	simulation	NOUN
bionys-549	70	4	and	and	CCONJ
bionys-549	70	5	docking	dock	VERB
bionys-549	70	6	bakal	bakal	PROPN
bionys-549	70	7	et	et	PROPN
bionys-549	70	8	al	al	PROPN
bionys-549	70	9	.	.	PROPN
bionys-549	71	1	(	(	PUNCT
bionys-549	71	2	2022	2022	NUM
bionys-549	71	3	)	)	PUNCT
bionys-549	71	4	identified	identify	VERB
bionys-549	71	5	(	(	PUNCT
bionys-549	71	6	z)-2-(5-((1	z)-2-(5-((1	PROPN
bionys-549	71	7	-	-	PUNCT
bionys-549	71	8	methoxynaphthalen2	methoxynaphthalen2	NOUN
bionys-549	71	9	-	-	PUNCT
bionys-549	71	10	yl)methylene)-4	yl)methylene)-4	VERB
bionys-549	71	11	-	-	PUNCT
bionys-549	71	12	oxo-2	oxo-2	NOUN
bionys-549	71	13	-	-	PUNCT
bionys-549	71	14	thioxothiazolidin-3	thioxothiazolidin-3	NUM
bionys-549	71	15	-	-	PUNCT
bionys-549	71	16	yl	yl	NOUN
bionys-549	71	17	)	)	PUNCT
bionys-549	71	18	acetic	acetic	ADJ
bionys-549	71	19	acid	acid	NOUN
bionys-549	71	20	derivative	derivative	NOUN
bionys-549	71	21	as	as	ADP
bionys-549	71	22	aldose	aldose	PROPN
bionys-549	71	23	reductase	reductase	NOUN
bionys-549	71	24	inhibitor	inhibitor	NOUN
bionys-549	71	25	(	(	PUNCT
bionys-549	71	26	fig	fig	NOUN
bionys-549	71	27	.	.	PUNCT
bionys-549	72	1	1	1	NUM
bionys-549	72	2	)	)	PUNCT
bionys-549	72	3	.	.	PUNCT
bionys-549	73	1	recent	recent	ADJ
bionys-549	73	2	reports	report	NOUN
bionys-549	73	3	on	on	ADP
bionys-549	73	4	the	the	DET
bionys-549	73	5	identification	identification	NOUN
bionys-549	73	6	of	of	ADP
bionys-549	73	7	thiazolidin	thiazolidin	NOUN
bionys-549	73	8	-	-	PUNCT
bionys-549	73	9	dione	dione	NOUN
bionys-549	73	10	through	through	ADP
bionys-549	73	11	docking	docking	NOUN
bionys-549	73	12	showed	show	VERB
bionys-549	73	13	interactions	interaction	NOUN
bionys-549	73	14	with	with	ADP
bionys-549	73	15	residues	residue	NOUN
bionys-549	73	16	trp111	trp111	ADJ
bionys-549	73	17	,	,	PUNCT
bionys-549	73	18	ala299	ala299	PROPN
bionys-549	73	19	,	,	PUNCT
bionys-549	73	20	leu300	leu300	PROPN
bionys-549	73	21	and	and	CCONJ
bionys-549	73	22	phe122	phe122	PROPN
bionys-549	73	23	located	locate	VERB
bionys-549	73	24	at	at	ADP
bionys-549	73	25	the	the	DET
bionys-549	73	26	specificity	specificity	NOUN
bionys-549	73	27	pocket	pocket	NOUN
bionys-549	73	28	(	(	PUNCT
bionys-549	73	29	balestri	balestri	NOUN
bionys-549	73	30	et	et	PROPN
bionys-549	73	31	al	al	PROPN
bionys-549	73	32	.	.	PROPN
bionys-549	73	33	,	,	PUNCT
bionys-549	73	34	2022	2022	NUM
bionys-549	73	35	)	)	PUNCT
bionys-549	73	36	,	,	PUNCT
bionys-549	73	37	and	and	CCONJ
bionys-549	73	38	reviewed	review	VERB
bionys-549	73	39	various	various	ADJ
bionys-549	73	40	natural	natural	ADJ
bionys-549	73	41	and	and	CCONJ
bionys-549	73	42	synthetic	synthetic	ADJ
bionys-549	73	43	compounds	compound	NOUN
bionys-549	73	44	that	that	PRON
bionys-549	73	45	act	act	VERB
bionys-549	73	46	as	as	ADP
bionys-549	73	47	aldose	aldose	ADJ
bionys-549	73	48	reductase	reductase	NOUN
bionys-549	73	49	inhibitors	inhibitor	NOUN
bionys-549	73	50	,	,	PUNCT
bionys-549	73	51	including	include	VERB
bionys-549	73	52	cyclic	cyclic	ADJ
bionys-549	73	53	imides	imide	NOUN
bionys-549	73	54	,	,	PUNCT
bionys-549	73	55	polyphenols	polyphenol	NOUN
bionys-549	73	56	,	,	PUNCT
bionys-549	73	57	and	and	CCONJ
bionys-549	73	58	carboxylic	carboxylic	ADJ
bionys-549	73	59	acid	acid	NOUN
bionys-549	73	60	derivatives	derivative	NOUN
bionys-549	73	61	(	(	PUNCT
bionys-549	73	62	friesner	friesner	NOUN
bionys-549	73	63	et	et	PROPN
bionys-549	73	64	al	al	PROPN
bionys-549	73	65	.	.	PROPN
bionys-549	73	66	,	,	PUNCT
bionys-549	73	67	2006	2006	NUM
bionys-549	73	68	;	;	PUNCT
bionys-549	73	69	zhu	zhu	PROPN
bionys-549	73	70	et	et	PROPN
bionys-549	73	71	al	al	PROPN
bionys-549	73	72	.	.	PROPN
bionys-549	73	73	,	,	PUNCT
bionys-549	73	74	2022	2022	NUM
bionys-549	73	75	)	)	PUNCT
bionys-549	73	76	.	.	PUNCT
bionys-549	74	1	zhu	zhu	PROPN
bionys-549	74	2	et	et	PROPN
bionys-549	74	3	al	al	PROPN
bionys-549	74	4	.	.	PROPN
bionys-549	74	5	(	(	PUNCT
bionys-549	74	6	2022	2022	NUM
bionys-549	74	7	)	)	PUNCT
bionys-549	74	8	revealed	reveal	VERB
bionys-549	74	9	the	the	DET
bionys-549	74	10	purine	purine	NOUN
bionys-549	74	11	derivatives	derivative	NOUN
bionys-549	74	12	(	(	PUNCT
bionys-549	74	13	fig	fig	NOUN
bionys-549	74	14	.	.	NOUN
bionys-549	74	15	1	1	NUM
bionys-549	74	16	)	)	PUNCT
bionys-549	74	17	as	as	ADP
bionys-549	74	18	a	a	DET
bionys-549	74	19	potential	potential	ADJ
bionys-549	74	20	inhibitor	inhibitor	NOUN
bionys-549	74	21	of	of	ADP
bionys-549	74	22	aldose	aldose	DET
bionys-549	74	23	reductase	reductase	NOUN
bionys-549	74	24	having	have	VERB
bionys-549	74	25	an	an	DET
bionys-549	74	26	ic50	ic50	PROPN
bionys-549	74	27	value	value	NOUN
bionys-549	74	28	of	of	ADP
bionys-549	74	29	0.038	0.038	NUM
bionys-549	74	30	μm	μm	NOUN
bionys-549	74	31	.	.	PUNCT
bionys-549	75	1	these	these	DET
bionys-549	75	2	reports	report	NOUN
bionys-549	75	3	suggest	suggest	VERB
bionys-549	75	4	that	that	SCONJ
bionys-549	75	5	there	there	PRON
bionys-549	75	6	is	be	VERB
bionys-549	75	7	still	still	ADV
bionys-549	75	8	no	no	DET
bionys-549	75	9	selective	selective	ADJ
bionys-549	75	10	inhibitor	inhibitor	NOUN
bionys-549	75	11	for	for	ADP
bionys-549	75	12	aldose	aldose	DET
bionys-549	75	13	reductase	reductase	NOUN
bionys-549	75	14	warranting	warrant	VERB
bionys-549	75	15	further	further	ADJ
bionys-549	75	16	search	search	NOUN
bionys-549	75	17	for	for	ADP
bionys-549	75	18	a	a	DET
bionys-549	75	19	candidate	candidate	NOUN
bionys-549	75	20	molecule	molecule	NOUN
bionys-549	75	21	to	to	PART
bionys-549	75	22	address	address	VERB
bionys-549	75	23	the	the	DET
bionys-549	75	24	diabetic	diabetic	ADJ
bionys-549	75	25	complication	complication	NOUN
bionys-549	75	26	affecting	affect	VERB
bionys-549	75	27	the	the	DET
bionys-549	75	28	eye	eye	NOUN
bionys-549	75	29	.	.	PUNCT
bionys-549	76	1	materials	material	NOUN
bionys-549	76	2	and	and	CCONJ
bionys-549	76	3	methods	method	NOUN
bionys-549	76	4	overview	overview	NOUN
bionys-549	76	5	of	of	ADP
bionys-549	76	6	steps	step	NOUN
bionys-549	76	7	used	use	VERB
bionys-549	76	8	in	in	ADP
bionys-549	76	9	the	the	DET
bionys-549	76	10	present	present	ADJ
bionys-549	76	11	study	study	NOUN
bionys-549	76	12	is	be	AUX
bionys-549	76	13	given	give	VERB
bionys-549	76	14	in	in	ADP
bionys-549	76	15	fig	fig	NOUN
bionys-549	76	16	.	.	PUNCT
bionys-549	77	1	2	2	X
bionys-549	77	2	.	.	X
bionys-549	77	3	an	an	DET
bionys-549	77	4	initial	initial	ADJ
bionys-549	77	5	docking	docking	NOUN
bionys-549	77	6	analysis	analysis	NOUN
bionys-549	77	7	was	be	AUX
bionys-549	77	8	carried	carry	VERB
bionys-549	77	9	out	out	ADP
bionys-549	77	10	with	with	ADP
bionys-549	77	11	set	set	NOUN
bionys-549	77	12	of	of	ADP
bionys-549	77	13	natural	natural	ADJ
bionys-549	77	14	compounds	compound	NOUN
bionys-549	77	15	that	that	PRON
bionys-549	77	16	were	be	AUX
bionys-549	77	17	tested	test	VERB
bionys-549	77	18	in	in	ADP
bionys-549	77	19	vitro	vitro	X
bionys-549	77	20	for	for	ADP
bionys-549	77	21	inhibition	inhibition	NOUN
bionys-549	77	22	of	of	ADP
bionys-549	77	23	aldose	aldose	DET
bionys-549	77	24	reductase	reductase	NOUN
bionys-549	77	25	.	.	PUNCT
bionys-549	78	1	we	we	PRON
bionys-549	78	2	understood	understand	VERB
bionys-549	78	3	the	the	DET
bionys-549	78	4	pharmacophore	pharmacophore	NOUN
bionys-549	78	5	requirements	requirement	NOUN
bionys-549	78	6	using	use	VERB
bionys-549	78	7	the	the	DET
bionys-549	78	8	same	same	ADJ
bionys-549	78	9	set	set	NOUN
bionys-549	78	10	of	of	ADP
bionys-549	78	11	compounds	compound	NOUN
bionys-549	78	12	that	that	PRON
bionys-549	78	13	were	be	AUX
bionys-549	78	14	likely	likely	ADJ
bionys-549	78	15	to	to	PART
bionys-549	78	16	bind	bind	VERB
bionys-549	78	17	to	to	ADP
bionys-549	78	18	the	the	DET
bionys-549	78	19	target	target	NOUN
bionys-549	78	20	region	region	NOUN
bionys-549	78	21	i.e.	i.e.	X
bionys-549	78	22	the	the	DET
bionys-549	78	23	specificity	specificity	NOUN
bionys-549	78	24	region	region	NOUN
bionys-549	78	25	of	of	ADP
bionys-549	78	26	our	our	PRON
bionys-549	78	27	enzyme	enzyme	NOUN
bionys-549	78	28	active	active	ADJ
bionys-549	78	29	site	site	NOUN
bionys-549	78	30	.	.	PUNCT
bionys-549	79	1	then	then	ADV
bionys-549	79	2	a	a	DET
bionys-549	79	3	pharmacophore	pharmacophore	NOUN
bionys-549	79	4	model	model	NOUN
bionys-549	79	5	was	be	AUX
bionys-549	79	6	developed	develop	VERB
bionys-549	79	7	using	use	VERB
bionys-549	79	8	a	a	DET
bionys-549	79	9	set	set	NOUN
bionys-549	79	10	of	of	ADP
bionys-549	79	11	analogues	analogue	NOUN
bionys-549	79	12	from	from	ADP
bionys-549	79	13	the	the	DET
bionys-549	79	14	most	most	ADV
bionys-549	79	15	likely	likely	ADJ
bionys-549	79	16	compound	compound	NOUN
bionys-549	79	17	that	that	PRON
bionys-549	79	18	could	could	AUX
bionys-549	79	19	be	be	AUX
bionys-549	79	20	considered	consider	VERB
bionys-549	79	21	as	as	ADP
bionys-549	79	22	a	a	DET
bionys-549	79	23	starting	starting	NOUN
bionys-549	79	24	point	point	NOUN
bionys-549	79	25	for	for	ADP
bionys-549	79	26	finding	find	VERB
bionys-549	79	27	a	a	DET
bionys-549	79	28	perfect	perfect	ADJ
bionys-549	79	29	inhibitor	inhibitor	NOUN
bionys-549	79	30	.	.	PUNCT
bionys-549	80	1	a	a	DET
bionys-549	80	2	3d	3d	NUM
bionys-549	80	3	database	database	NOUN
bionys-549	80	4	search	search	NOUN
bionys-549	80	5	was	be	AUX
bionys-549	80	6	carried	carry	VERB
bionys-549	80	7	out	out	ADP
bionys-549	80	8	using	use	VERB
bionys-549	80	9	the	the	DET
bionys-549	80	10	obtained	obtain	VERB
bionys-549	80	11	pharmacophore	pharmacophore	NOUN
bionys-549	80	12	model	model	NOUN
bionys-549	80	13	and	and	CCONJ
bionys-549	80	14	a	a	DET
bionys-549	80	15	final	final	ADJ
bionys-549	80	16	docking	docking	NOUN
bionys-549	80	17	analysis	analysis	NOUN
bionys-549	80	18	was	be	AUX
bionys-549	80	19	carried	carry	VERB
bionys-549	80	20	out	out	ADP
bionys-549	80	21	using	use	VERB
bionys-549	80	22	the	the	DET
bionys-549	80	23	hits	hit	NOUN
bionys-549	80	24	from	from	ADP
bionys-549	80	25	the	the	DET
bionys-549	80	26	search	search	NOUN
bionys-549	80	27	to	to	PART
bionys-549	80	28	screen	screen	VERB
bionys-549	80	29	out	out	ADP
bionys-549	80	30	fewer	few	ADJ
bionys-549	80	31	effective	effective	ADJ
bionys-549	80	32	compounds	compound	NOUN
bionys-549	80	33	.	.	PUNCT
bionys-549	81	1	in	in	ADP
bionys-549	81	2	silico	silico	NOUN
bionys-549	81	3	tools	tool	NOUN
bionys-549	81	4	such	such	ADJ
bionys-549	81	5	as	as	ADP
bionys-549	81	6	virtual	virtual	ADJ
bionys-549	81	7	library	library	NOUN
bionys-549	81	8	screening	screening	NOUN
bionys-549	81	9	,	,	PUNCT
bionys-549	81	10	docking	docking	NOUN
bionys-549	81	11	methods	method	NOUN
bionys-549	81	12	,	,	PUNCT
bionys-549	81	13	ligprep	ligprep	NOUN
bionys-549	81	14	,	,	PUNCT
bionys-549	81	15	protein	protein	NOUN
bionys-549	81	16	preparation	preparation	NOUN
bionys-549	81	17	and	and	CCONJ
bionys-549	81	18	pharmacophore	pharmacophore	ADJ
bionys-549	81	19	analysis	analysis	NOUN
bionys-549	81	20	were	be	AUX
bionys-549	81	21	carried	carry	VERB
bionys-549	81	22	out	out	ADP
bionys-549	81	23	using	use	VERB
bionys-549	81	24	the	the	DET
bionys-549	81	25	gui	gui	NOUN
bionys-549	81	26	maestro	maestro	NOUN
bionys-549	81	27	v9.1	v9.1	PROPN
bionys-549	81	28	of	of	ADP
bionys-549	81	29	the	the	DET
bionys-549	81	30	schrödinger	schrödinger	ADJ
bionys-549	81	31	software	software	NOUN
bionys-549	81	32	(	(	PUNCT
bionys-549	81	33	rajeswari	rajeswari	X
bionys-549	81	34	et	et	PROPN
bionys-549	81	35	al	al	PROPN
bionys-549	81	36	.	.	PROPN
bionys-549	81	37	,	,	PUNCT
bionys-549	81	38	2014	2014	NUM
bionys-549	81	39	)	)	PUNCT
bionys-549	81	40	.	.	PUNCT
bionys-549	82	1	phase	phase	NOUN
bionys-549	82	2	module	module	NOUN
bionys-549	82	3	of	of	ADP
bionys-549	82	4	schrödinger	schrödinger	ADJ
bionys-549	82	5	software	software	NOUN
bionys-549	82	6	was	be	AUX
bionys-549	82	7	used	use	VERB
bionys-549	82	8	to	to	PART
bionys-549	82	9	build	build	VERB
bionys-549	82	10	a	a	DET
bionys-549	82	11	six	six	NUM
bionys-549	82	12	-	-	PUNCT
bionys-549	82	13	point	point	NOUN
bionys-549	82	14	pharmacophore	pharmacophore	NOUN
bionys-549	82	15	(	(	PUNCT
bionys-549	82	16	verma	verma	PROPN
bionys-549	82	17	&	&	CCONJ
bionys-549	82	18	thareja	thareja	PROPN
bionys-549	82	19	,	,	PUNCT
bionys-549	82	20	2020	2020	NUM
bionys-549	82	21	)	)	PUNCT
bionys-549	82	22	.	.	PUNCT
bionys-549	83	1	data	datum	NOUN
bionys-549	83	2	set	set	VERB
bionys-549	83	3	ligands	ligand	NOUN
bionys-549	83	4	for	for	ADP
bionys-549	83	5	initial	initial	ADJ
bionys-549	83	6	analysis	analysis	NOUN
bionys-549	83	7	the	the	DET
bionys-549	83	8	initial	initial	ADJ
bionys-549	83	9	set	set	NOUN
bionys-549	83	10	of	of	ADP
bionys-549	83	11	natural	natural	ADJ
bionys-549	83	12	and	and	CCONJ
bionys-549	83	13	synthetic	synthetic	ADJ
bionys-549	83	14	ligands	ligand	NOUN
bionys-549	83	15	were	be	AUX
bionys-549	83	16	obtained	obtain	VERB
bionys-549	83	17	from	from	ADP
bionys-549	83	18	different	different	ADJ
bionys-549	83	19	literature	literature	NOUN
bionys-549	83	20	and	and	CCONJ
bionys-549	83	21	deposited	deposit	VERB
bionys-549	83	22	pdb	pdb	PROPN
bionys-549	83	23	structures	structure	NOUN
bionys-549	83	24	,	,	PUNCT
bionys-549	83	25	respectively	respectively	ADV
bionys-549	83	26	.	.	PUNCT
bionys-549	84	1	we	we	PRON
bionys-549	84	2	collected	collect	VERB
bionys-549	84	3	diverse	diverse	ADJ
bionys-549	84	4	natural	natural	ADJ
bionys-549	84	5	compounds	compound	NOUN
bionys-549	84	6	(	(	PUNCT
bionys-549	84	7	chaudhry	chaudhry	PROPN
bionys-549	84	8	et	et	PROPN
bionys-549	84	9	al	al	PROPN
bionys-549	84	10	.	.	PROPN
bionys-549	84	11	,	,	PUNCT
bionys-549	84	12	1983	1983	NUM
bionys-549	84	13	)	)	PUNCT
bionys-549	84	14	that	that	PRON
bionys-549	84	15	have	have	AUX
bionys-549	84	16	been	be	AUX
bionys-549	84	17	found	find	VERB
bionys-549	84	18	effective	effective	ADJ
bionys-549	84	19	in	in	ADP
bionys-549	84	20	vitro	vitro	X
bionys-549	84	21	.	.	PUNCT
bionys-549	85	1	ligands	ligand	NOUN
bionys-549	85	2	from	from	ADP
bionys-549	85	3	co	co	ADJ
bionys-549	85	4	-	-	ADJ
bionys-549	85	5	crystallized	crystallized	ADJ
bionys-549	85	6	pdb	pdb	NOUN
bionys-549	85	7	structures	structure	NOUN
bionys-549	85	8	were	be	AUX
bionys-549	85	9	obtained	obtain	VERB
bionys-549	85	10	to	to	PART
bionys-549	85	11	confirm	confirm	VERB
bionys-549	85	12	the	the	DET
bionys-549	85	13	reliability	reliability	NOUN
bionys-549	85	14	of	of	ADP
bionys-549	85	15	our	our	PRON
bionys-549	85	16	results	result	NOUN
bionys-549	85	17	from	from	ADP
bionys-549	85	18	the	the	DET
bionys-549	85	19	initial	initial	ADJ
bionys-549	85	20	docking	docking	NOUN
bionys-549	85	21	analysis	analysis	NOUN
bionys-549	85	22	.	.	PUNCT
bionys-549	86	1	also	also	ADV
bionys-549	86	2	,	,	PUNCT
bionys-549	86	3	methylglyoxal	methylglyoxal	ADJ
bionys-549	86	4	structure	structure	NOUN
bionys-549	86	5	was	be	AUX
bionys-549	86	6	obtained	obtain	VERB
bionys-549	86	7	to	to	PART
bionys-549	86	8	confirm	confirm	VERB
bionys-549	86	9	its	its	PRON
bionys-549	86	10	binding	binding	NOUN
bionys-549	86	11	to	to	ADP
bionys-549	86	12	the	the	DET
bionys-549	86	13	anionic	anionic	ADJ
bionys-549	86	14	region	region	NOUN
bionys-549	86	15	of	of	ADP
bionys-549	86	16	the	the	DET
bionys-549	86	17	binding	bind	VERB
bionys-549	86	18	pocket	pocket	NOUN
bionys-549	86	19	.	.	PUNCT
bionys-549	87	1	the	the	DET
bionys-549	87	2	set	set	NOUN
bionys-549	87	3	of	of	ADP
bionys-549	87	4	natural	natural	ADJ
bionys-549	87	5	and	and	CCONJ
bionys-549	87	6	synthetic	synthetic	ADJ
bionys-549	87	7	compounds	compound	NOUN
bionys-549	87	8	as	as	SCONJ
bionys-549	87	9	described	describe	VERB
bionys-549	87	10	earlier	early	ADV
bionys-549	87	11	were	be	AUX
bionys-549	87	12	created	create	VERB
bionys-549	87	13	using	use	VERB
bionys-549	87	14	symyx	symyx	NOUN
bionys-549	87	15	draw	draw	VERB
bionys-549	87	16	v4.0	v4.0	NOUN
bionys-549	87	17	.	.	PUNCT
bionys-549	88	1	they	they	PRON
bionys-549	88	2	were	be	AUX
bionys-549	88	3	prepared	prepare	VERB
bionys-549	88	4	using	use	VERB
bionys-549	88	5	ligprep	ligprep	ADJ
bionys-549	88	6	module	module	NOUN
bionys-549	88	7	of	of	ADP
bionys-549	88	8	the	the	DET
bionys-549	88	9	gui	gui	NOUN
bionys-549	88	10	maestro	maestro	PROPN
bionys-549	88	11	v9.1	v9.1	PROPN
bionys-549	88	12	.	.	PUNCT
bionys-549	89	1	docking	docking	NOUN
bionys-549	89	2	was	be	AUX
bionys-549	89	3	employed	employ	VERB
bionys-549	89	4	with	with	ADP
bionys-549	89	5	extra	extra	ADJ
bionys-549	89	6	-	-	ADJ
bionys-549	89	7	precision	precision	ADJ
bionys-549	89	8	mode	mode	NOUN
bionys-549	89	9	(	(	PUNCT
bionys-549	89	10	xp	xp	INTJ
bionys-549	89	11	mode	mode	PROPN
bionys-549	89	12	)	)	PUNCT
bionys-549	89	13	of	of	ADP
bionys-549	89	14	glide	glide	ADJ
bionys-549	89	15	software	software	NOUN
bionys-549	89	16	of	of	ADP
bionys-549	89	17	the	the	DET
bionys-549	89	18	gui	gui	NOUN
bionys-549	89	19	maestro	maestro	PROPN
bionys-549	89	20	v9.1	v9.1	PROPN
bionys-549	89	21	.	.	PUNCT
bionys-549	90	1	receptor	receptor	NOUN
bionys-549	90	2	protein	protein	NOUN
bionys-549	90	3	the	the	DET
bionys-549	90	4	receptor	receptor	NOUN
bionys-549	90	5	protein	protein	NOUN
bionys-549	90	6	was	be	AUX
bionys-549	90	7	retrieved	retrieve	VERB
bionys-549	90	8	using	use	VERB
bionys-549	90	9	the	the	DET
bionys-549	90	10	protein	protein	NOUN
bionys-549	90	11	data	datum	NOUN
bionys-549	90	12	bank	bank	NOUN
bionys-549	90	13	which	which	PRON
bionys-549	90	14	is	be	AUX
bionys-549	90	15	a	a	DET
bionys-549	90	16	depository	depository	NOUN
bionys-549	90	17	of	of	ADP
bionys-549	90	18	protein	protein	NOUN
bionys-549	90	19	structures	structure	NOUN
bionys-549	90	20	.	.	PUNCT
bionys-549	91	1	the	the	DET
bionys-549	91	2	structure	structure	NOUN
bionys-549	91	3	of	of	ADP
bionys-549	91	4	aldose	aldose	DET
bionys-549	91	5	reductase	reductase	NOUN
bionys-549	91	6	bound	bind	VERB
bionys-549	91	7	to	to	ADP
bionys-549	91	8	two	two	NUM
bionys-549	91	9	molecules	molecule	NOUN
bionys-549	91	10	of	of	ADP
bionys-549	91	11	benzothiazepine	benzothiazepine	NOUN
bionys-549	91	12	inhibitor	inhibitor	NOUN
bionys-549	91	13	(	(	PUNCT
bionys-549	91	14	pdb	pdb	PROPN
bionys-549	91	15	i	i	PROPN
bionys-549	91	16	d	d	PROPN
bionys-549	91	17	:	:	PUNCT
bionys-549	91	18	3p2v	3p2v	NUM
bionys-549	91	19	)	)	PUNCT
bionys-549	91	20	at	at	ADP
bionys-549	91	21	the	the	DET
bionys-549	91	22	resolution	resolution	NOUN
bionys-549	91	23	of	of	ADP
bionys-549	91	24	1.69	1.69	NUM
bionys-549	91	25	ǻ	ǻ	NOUN
bionys-549	91	26	was	be	AUX
bionys-549	91	27	chosen	choose	VERB
bionys-549	91	28	as	as	ADP
bionys-549	91	29	the	the	DET
bionys-549	91	30	receptor	receptor	NOUN
bionys-549	91	31	for	for	ADP
bionys-549	91	32	all	all	DET
bionys-549	91	33	further	further	ADJ
bionys-549	91	34	studies	study	NOUN
bionys-549	91	35	(	(	PUNCT
bionys-549	91	36	fig	fig	NOUN
bionys-549	91	37	.	.	PUNCT
bionys-549	92	1	3	3	NUM
bionys-549	92	2	)	)	PUNCT
bionys-549	92	3	.	.	PUNCT
bionys-549	93	1	this	this	PRON
bionys-549	93	2	is	be	AUX
bionys-549	93	3	the	the	DET
bionys-549	93	4	structure	structure	NOUN
bionys-549	93	5	of	of	ADP
bionys-549	93	6	aldose	aldose	DET
bionys-549	93	7	reductase	reductase	NOUN
bionys-549	93	8	which	which	PRON
bionys-549	93	9	is	be	AUX
bionys-549	93	10	a	a	DET
bionys-549	93	11	316aa	316aa	NOUN
bionys-549	93	12	long	long	ADJ
bionys-549	93	13	and	and	CCONJ
bionys-549	93	14	co	co	VERB
bionys-549	93	15	-	-	VERB
bionys-549	93	16	crystallized	crystallize	VERB
bionys-549	93	17	with	with	ADP
bionys-549	93	18	two	two	NUM
bionys-549	93	19	benzothiazepine	benzothiazepine	ADP
bionys-549	93	20	inhibitors	inhibitor	NOUN
bionys-549	93	21	in	in	ADP
bionys-549	93	22	its	its	PRON
bionys-549	93	23	active	active	ADJ
bionys-549	93	24	site	site	NOUN
bionys-549	93	25	.	.	PUNCT
bionys-549	94	1	the	the	DET
bionys-549	94	2	compounds	compound	NOUN
bionys-549	94	3	with	with	ADP
bionys-549	94	4	structure	structure	NOUN
bionys-549	94	5	shown	show	VERB
bionys-549	94	6	in	in	ADP
bionys-549	94	7	fig	fig	NOUN
bionys-549	94	8	.	.	PUNCT
bionys-549	94	9	4	4	NUM
bionys-549	94	10	are	be	AUX
bionys-549	94	11	taken	take	VERB
bionys-549	94	12	for	for	ADP
bionys-549	94	13	preliminary	preliminary	ADJ
bionys-549	94	14	screening	screening	NOUN
bionys-549	94	15	.	.	PUNCT
bionys-549	95	1	results	result	NOUN
bionys-549	95	2	in	in	ADP
bionys-549	95	3	our	our	PRON
bionys-549	95	4	work	work	NOUN
bionys-549	95	5	,	,	PUNCT
bionys-549	95	6	we	we	PRON
bionys-549	95	7	docked	dock	VERB
bionys-549	95	8	methylglyoxal	methylglyoxal	NOUN
bionys-549	95	9	(	(	PUNCT
bionys-549	95	10	a	a	DET
bionys-549	95	11	toxic	toxic	ADJ
bionys-549	95	12	aldehyde	aldehyde	NOUN
bionys-549	95	13	)	)	PUNCT
bionys-549	95	14	and	and	CCONJ
bionys-549	95	15	found	find	VERB
bionys-549	95	16	it	it	PRON
bionys-549	95	17	occupying	occupy	VERB
bionys-549	95	18	the	the	DET
bionys-549	95	19	exact	exact	ADJ
bionys-549	95	20	same	same	ADJ
bionys-549	95	21	anionic	anionic	ADJ
bionys-549	95	22	region	region	NOUN
bionys-549	95	23	.	.	PUNCT
bionys-549	96	1	therefore	therefore	ADV
bionys-549	96	2	,	,	PUNCT
bionys-549	96	3	we	we	PRON
bionys-549	96	4	used	use	VERB
bionys-549	96	5	the	the	DET
bionys-549	96	6	docked	docked	ADJ
bionys-549	96	7	fig	fig	NOUN
bionys-549	96	8	.	.	PUNCT
bionys-549	97	1	1	1	X
bionys-549	97	2	.	.	X
bionys-549	97	3	structures	structure	NOUN
bionys-549	97	4	of	of	ADP
bionys-549	97	5	known	know	VERB
bionys-549	97	6	aldose	aldose	ADJ
bionys-549	97	7	reductase	reductase	NOUN
bionys-549	97	8	inhibitors	inhibitor	NOUN
bionys-549	97	9	(	(	PUNCT
bionys-549	97	10	z)-2-(5-((1	z)-2-(5-((1	NOUN
bionys-549	97	11	-	-	PUNCT
bionys-549	97	12	methoxynaphthalen-2	methoxynaphthalen-2	NUM
bionys-549	97	13	-	-	PUNCT
bionys-549	97	14	yl)methylene)-4oxo-2	yl)methylene)-4oxo-2	NOUN
bionys-549	97	15	-	-	PUNCT
bionys-549	97	16	thioxothiazolidin-3	thioxothiazolidin-3	NUM
bionys-549	97	17	-	-	ADJ
bionys-549	97	18	yl)acetic	yl)acetic	ADJ
bionys-549	97	19	acid	acid	NOUN
bionys-549	97	20	,	,	PUNCT
bionys-549	97	21	2-(6-((4	2-(6-((4	NUM
bionys-549	97	22	-	-	PUNCT
bionys-549	97	23	bromo2	bromo2	NOUN
bionys-549	97	24	-	-	PUNCT
bionys-549	97	25	fluorobenzyl)amino)-9h	fluorobenzyl)amino)-9h	NOUN
bionys-549	97	26	-	-	PUNCT
bionys-549	97	27	purin-9	purin-9	NUM
bionys-549	97	28	-	-	ADJ
bionys-549	97	29	yl)acetic	yl)acetic	ADJ
bionys-549	97	30	acid	acid	NOUN
bionys-549	97	31	(	(	PUNCT
bionys-549	97	32	zhu	zhu	X
bionys-549	97	33	et	et	PROPN
bionys-549	97	34	al	al	PROPN
bionys-549	97	35	.	.	PROPN
bionys-549	97	36	,	,	PUNCT
bionys-549	97	37	2022	2022	NUM
bionys-549	97	38	)	)	PUNCT
bionys-549	97	39	fig	fig	NOUN
bionys-549	97	40	.	.	PUNCT
bionys-549	98	1	2	2	X
bionys-549	98	2	.	.	NUM
bionys-549	98	3	steps	step	NOUN
bionys-549	98	4	used	use	VERB
bionys-549	98	5	in	in	ADP
bionys-549	98	6	identification	identification	NOUN
bionys-549	98	7	of	of	ADP
bionys-549	98	8	hits	hit	NOUN
bionys-549	98	9	126	126	NUM
bionys-549	98	10	biologica	biologica	NOUN
bionys-549	98	11	nyssana	nyssana	PROPN
bionys-549	99	1	●	●	PUNCT
bionys-549	99	2	15	15	NUM
bionys-549	99	3	(	(	PUNCT
bionys-549	99	4	2	2	NUM
bionys-549	99	5	)	)	PUNCT
bionys-549	99	6	december	december	PROPN
bionys-549	99	7	2024	2024	NUM
bionys-549	99	8	:	:	PUNCT
bionys-549	99	9	nagarajan	nagarajan	NOUN
bionys-549	99	10	et	et	PROPN
bionys-549	99	11	al	al	PROPN
bionys-549	99	12	.	.	PUNCT
bionys-549	100	1	●	●	PUNCT
bionys-549	100	2	beyond	beyond	ADP
bionys-549	100	3	boundaries	boundary	NOUN
bionys-549	100	4	:	:	PUNCT
bionys-549	100	5	pioneering	pioneer	VERB
bionys-549	100	6	discoveries	discovery	NOUN
bionys-549	100	7	in	in	ADP
bionys-549	100	8	aldose	aldose	PRON
bionys-549	100	9	reductase	reductase	NOUN
bionys-549	100	10	inhibition	inhibition	NOUN
bionys-549	100	11	for	for	ADP
bionys-549	100	12	diabetic	diabetic	ADJ
bionys-549	100	13	neuropathy	neuropathy	ADJ
bionys-549	100	14	fig	fig	NOUN
bionys-549	100	15	.	.	PUNCT
bionys-549	101	1	3	3	X
bionys-549	101	2	.	.	X
bionys-549	101	3	structure	structure	NOUN
bionys-549	101	4	of	of	ADP
bionys-549	101	5	aldose	aldose	DET
bionys-549	101	6	reductase	reductase	NOUN
bionys-549	101	7	bound	bind	VERB
bionys-549	101	8	to	to	PART
bionys-549	101	9	novel	novel	VERB
bionys-549	101	10	benzothiazepine	benzothiazepine	ADP
bionys-549	101	11	pdb	pdb	PROPN
bionys-549	101	12	i	i	PROPN
bionys-549	101	13	d	d	PROPN
bionys-549	101	14	:	:	PUNCT
bionys-549	101	15	3p2v	3p2v	NUM
bionys-549	101	16	fig	fig	NOUN
bionys-549	101	17	.	.	PUNCT
bionys-549	102	1	4	4	X
bionys-549	102	2	.	.	X
bionys-549	102	3	the	the	DET
bionys-549	102	4	quercetin	quercetin	NOUN
bionys-549	102	5	scaffold	scaffold	NOUN
bionys-549	102	6	used	use	VERB
bionys-549	102	7	to	to	PART
bionys-549	102	8	derive	derive	VERB
bionys-549	102	9	analogues	analogue	NOUN
bionys-549	102	10	for	for	ADP
bionys-549	102	11	pharmacophore	pharmacophore	NOUN
bionys-549	102	12	model	model	NOUN
bionys-549	102	13	development	development	NOUN
bionys-549	102	14	receptor	receptor	NOUN
bionys-549	102	15	-	-	PUNCT
bionys-549	102	16	ligand	ligand	NOUN
bionys-549	102	17	complex	complex	NOUN
bionys-549	102	18	for	for	ADP
bionys-549	102	19	further	further	ADJ
bionys-549	102	20	docking	dock	VERB
bionys-549	102	21	analysis	analysis	NOUN
bionys-549	102	22	with	with	ADP
bionys-549	102	23	the	the	DET
bionys-549	102	24	set	set	NOUN
bionys-549	102	25	of	of	ADP
bionys-549	102	26	natural	natural	ADJ
bionys-549	102	27	and	and	CCONJ
bionys-549	102	28	synthetic	synthetic	ADJ
bionys-549	102	29	compounds	compound	NOUN
bionys-549	102	30	.	.	PUNCT
bionys-549	103	1	grids	grid	NOUN
bionys-549	103	2	were	be	AUX
bionys-549	103	3	prepared	prepare	VERB
bionys-549	103	4	for	for	ADP
bionys-549	103	5	the	the	DET
bionys-549	103	6	anionic	anionic	ADJ
bionys-549	103	7	region	region	NOUN
bionys-549	103	8	,	,	PUNCT
bionys-549	103	9	important	important	ADJ
bionys-549	103	10	region	region	NOUN
bionys-549	103	11	and	and	CCONJ
bionys-549	103	12	the	the	DET
bionys-549	103	13	active	active	ADJ
bionys-549	103	14	packet	packet	NOUN
bionys-549	103	15	separately	separately	ADV
bionys-549	103	16	(	(	PUNCT
bionys-549	103	17	fig	fig	NOUN
bionys-549	103	18	.	.	PUNCT
bionys-549	103	19	5	5	NUM
bionys-549	103	20	)	)	PUNCT
bionys-549	103	21	.	.	PUNCT
bionys-549	104	1	quercetin	quercetin	NOUN
bionys-549	104	2	analogues	analogue	NOUN
bionys-549	104	3	(	(	PUNCT
bionys-549	104	4	fig	fig	NOUN
bionys-549	104	5	.	.	PUNCT
bionys-549	105	1	6	6	NUM
bionys-549	105	2	,	,	PUNCT
bionys-549	105	3	tab	tab	NOUN
bionys-549	105	4	.	.	NOUN
bionys-549	105	5	1	1	NUM
bionys-549	105	6	)	)	PUNCT
bionys-549	105	7	with	with	ADP
bionys-549	105	8	in	in	ADP
bionys-549	105	9	vitro	vitro	X
bionys-549	105	10	activity	activity	NOUN
bionys-549	105	11	(	(	PUNCT
bionys-549	105	12	kondhare	kondhare	NOUN
bionys-549	105	13	et	et	PROPN
bionys-549	105	14	al	al	PROPN
bionys-549	105	15	.	.	PROPN
bionys-549	105	16	,	,	PUNCT
bionys-549	105	17	2017	2017	NUM
bionys-549	105	18	)	)	PUNCT
bionys-549	105	19	were	be	AUX
bionys-549	105	20	used	use	VERB
bionys-549	105	21	to	to	PART
bionys-549	105	22	build	build	VERB
bionys-549	105	23	a	a	DET
bionys-549	105	24	qsar	qsar	NOUN
bionys-549	105	25	-	-	PUNCT
bionys-549	105	26	based	base	VERB
bionys-549	105	27	pharmacophore	pharmacophore	NOUN
bionys-549	105	28	model	model	NOUN
bionys-549	105	29	and	and	CCONJ
bionys-549	105	30	utilized	utilize	VERB
bionys-549	105	31	this	this	DET
bionys-549	105	32	model	model	NOUN
bionys-549	105	33	to	to	PART
bionys-549	105	34	screen	screen	VERB
bionys-549	105	35	a	a	DET
bionys-549	105	36	library	library	NOUN
bionys-549	105	37	of	of	ADP
bionys-549	105	38	natural	natural	ADJ
bionys-549	105	39	compounds	compound	NOUN
bionys-549	105	40	(	(	PUNCT
bionys-549	105	41	82,000	82,000	NUM
bionys-549	105	42	)	)	PUNCT
bionys-549	105	43	obtained	obtain	VERB
bionys-549	105	44	from	from	ADP
bionys-549	105	45	ibs	ib	NOUN
bionys-549	105	46	database	database	NOUN
bionys-549	105	47	in	in	ADP
bionys-549	105	48	search	search	NOUN
bionys-549	105	49	of	of	ADP
bionys-549	105	50	a	a	DET
bionys-549	105	51	selective	selective	ADJ
bionys-549	105	52	inhibitor	inhibitor	NOUN
bionys-549	105	53	.	.	PUNCT
bionys-549	106	1	these	these	DET
bionys-549	106	2	authors	author	NOUN
bionys-549	106	3	have	have	AUX
bionys-549	106	4	compared	compare	VERB
bionys-549	106	5	the	the	DET
bionys-549	106	6	activity	activity	NOUN
bionys-549	106	7	and	and	CCONJ
bionys-549	106	8	stated	state	VERB
bionys-549	106	9	that	that	SCONJ
bionys-549	106	10	“	"	PUNCT
bionys-549	106	11	improvement	improvement	NOUN
bionys-549	106	12	observed	observe	VERB
bionys-549	106	13	in	in	ADP
bionys-549	106	14	the	the	DET
bionys-549	106	15	inhibition	inhibition	NOUN
bionys-549	106	16	of	of	ADP
bionys-549	106	17	glycosylated	glycosylated	ADJ
bionys-549	106	18	sugar	sugar	NOUN
bionys-549	106	19	myricitrin	myricitrin	NOUN
bionys-549	106	20	was	be	AUX
bionys-549	106	21	higher	high	ADJ
bionys-549	106	22	than	than	ADP
bionys-549	106	23	that	that	PRON
bionys-549	106	24	observed	observe	VERB
bionys-549	106	25	for	for	ADP
bionys-549	106	26	the	the	DET
bionys-549	106	27	aglycone	aglycone	NOUN
bionys-549	106	28	myricetin	myricetin	NOUN
bionys-549	106	29	(	(	PUNCT
bionys-549	106	30	kondhare	kondhare	PROPN
bionys-549	106	31	et	et	PROPN
bionys-549	106	32	al	al	PROPN
bionys-549	106	33	.	.	PROPN
bionys-549	106	34	,	,	PUNCT
bionys-549	106	35	2017	2017	NUM
bionys-549	106	36	)	)	PUNCT
bionys-549	106	37	.	.	PUNCT
bionys-549	107	1	the	the	DET
bionys-549	107	2	specificity	specificity	NOUN
bionys-549	107	3	pocket	pocket	NOUN
bionys-549	107	4	forms	form	VERB
bionys-549	107	5	the	the	DET
bionys-549	107	6	entry	entry	NOUN
bionys-549	107	7	part	part	NOUN
bionys-549	107	8	of	of	ADP
bionys-549	107	9	the	the	DET
bionys-549	107	10	active	active	ADJ
bionys-549	107	11	site	site	NOUN
bionys-549	107	12	at	at	ADP
bionys-549	107	13	the	the	DET
bionys-549	107	14	external	external	ADJ
bionys-549	107	15	surface	surface	NOUN
bionys-549	107	16	.	.	PUNCT
bionys-549	108	1	the	the	DET
bionys-549	108	2	docking	dock	VERB
bionys-549	108	3	fig	fig	NOUN
bionys-549	108	4	.	.	PUNCT
bionys-549	109	1	5	5	X
bionys-549	109	2	.	.	X
bionys-549	109	3	the	the	DET
bionys-549	109	4	active	active	ADJ
bionys-549	109	5	site	site	NOUN
bionys-549	109	6	residues	residue	VERB
bionys-549	109	7	making	make	VERB
bionys-549	109	8	up	up	ADP
bionys-549	109	9	the	the	DET
bionys-549	109	10	two	two	NUM
bionys-549	109	11	regions	region	NOUN
bionys-549	109	12	fig	fig	NOUN
bionys-549	109	13	.	.	PUNCT
bionys-549	110	1	6	6	NUM
bionys-549	110	2	.	.	X
bionys-549	110	3	structures	structure	NOUN
bionys-549	110	4	chosen	choose	VERB
bionys-549	110	5	for	for	ADP
bionys-549	110	6	initial	initial	ADJ
bionys-549	110	7	docking	docking	NOUN
bionys-549	110	8	study	study	NOUN
bionys-549	110	9	analysis	analysis	NOUN
bionys-549	110	10	was	be	AUX
bionys-549	110	11	carried	carry	VERB
bionys-549	110	12	out	out	ADP
bionys-549	110	13	by	by	ADP
bionys-549	110	14	setting	set	VERB
bionys-549	110	15	grids	grid	NOUN
bionys-549	110	16	for	for	ADP
bionys-549	110	17	anion	anion	NOUN
bionys-549	110	18	binding	bind	VERB
bionys-549	110	19	,	,	PUNCT
bionys-549	110	20	region	region	NOUN
bionys-549	110	21	specific	specific	ADJ
bionys-549	110	22	to	to	ADP
bionys-549	110	23	binding	bind	VERB
bionys-549	110	24	and	and	CCONJ
bionys-549	110	25	the	the	DET
bionys-549	110	26	active	active	ADJ
bionys-549	110	27	regio	regio	NOUN
bionys-549	110	28	as	as	ADP
bionys-549	110	29	a	a	DET
bionys-549	110	30	whole	whole	NOUN
bionys-549	110	31	and	and	CCONJ
bionys-549	110	32	the	the	DET
bionys-549	110	33	same	same	ADJ
bionys-549	110	34	set	set	NOUN
bionys-549	110	35	of	of	ADP
bionys-549	110	36	compounds	compound	NOUN
bionys-549	110	37	were	be	AUX
bionys-549	110	38	docked	dock	VERB
bionys-549	110	39	into	into	ADP
bionys-549	110	40	these	these	DET
bionys-549	110	41	three	three	NUM
bionys-549	110	42	regions	region	NOUN
bionys-549	110	43	.	.	PUNCT
bionys-549	111	1	the	the	DET
bionys-549	111	2	obtained	obtain	VERB
bionys-549	111	3	results	result	NOUN
bionys-549	111	4	are	be	AUX
bionys-549	111	5	presented	present	VERB
bionys-549	111	6	in	in	ADP
bionys-549	111	7	tab	tab	NOUN
bionys-549	111	8	.	.	PUNCT
bionys-549	112	1	2	2	X
bionys-549	112	2	.	.	X
bionys-549	112	3	the	the	DET
bionys-549	112	4	reliability	reliability	NOUN
bionys-549	112	5	of	of	ADP
bionys-549	112	6	this	this	DET
bionys-549	112	7	analysis	analysis	NOUN
bionys-549	112	8	was	be	AUX
bionys-549	112	9	confirmed	confirm	VERB
bionys-549	112	10	by	by	ADP
bionys-549	112	11	the	the	DET
bionys-549	112	12	observations	observation	NOUN
bionys-549	112	13	made	make	VERB
bionys-549	112	14	with	with	ADP
bionys-549	112	15	respect	respect	NOUN
bionys-549	112	16	to	to	ADP
bionys-549	112	17	the	the	DET
bionys-549	112	18	binding	binding	NOUN
bionys-549	112	19	of	of	ADP
bionys-549	112	20	the	the	DET
bionys-549	112	21	toxic	toxic	ADJ
bionys-549	112	22	aldehyde	aldehyde	NOUN
bionys-549	112	23	,	,	PUNCT
bionys-549	112	24	methylglyoxal	methylglyoxal	NOUN
bionys-549	112	25	.	.	PUNCT
bionys-549	113	1	methylglyoxal	methylglyoxal	PROPN
bionys-549	113	2	docked	dock	VERB
bionys-549	113	3	with	with	ADP
bionys-549	113	4	the	the	DET
bionys-549	113	5	residues	residue	NOUN
bionys-549	113	6	trp111	trp111	ADJ
bionys-549	113	7	,	,	PUNCT
bionys-549	113	8	his110	his110	NOUN
bionys-549	113	9	and	and	CCONJ
bionys-549	113	10	tyr48	tyr48	VERB
bionys-549	113	11	of	of	ADP
bionys-549	113	12	anionic	anionic	ADJ
bionys-549	113	13	region	region	NOUN
bionys-549	113	14	showed	show	VERB
bionys-549	113	15	interaction	interaction	NOUN
bionys-549	113	16	which	which	PRON
bionys-549	113	17	reflected	reflect	VERB
bionys-549	113	18	the	the	DET
bionys-549	113	19	literature	literature	NOUN
bionys-549	113	20	studies	study	NOUN
bionys-549	113	21	explaining	explain	VERB
bionys-549	113	22	the	the	DET
bionys-549	113	23	detoxification	detoxification	NOUN
bionys-549	113	24	mechanism	mechanism	NOUN
bionys-549	113	25	.	.	PUNCT
bionys-549	114	1	also	also	ADV
bionys-549	114	2	,	,	PUNCT
bionys-549	114	3	the	the	DET
bionys-549	114	4	ligands	ligand	NOUN
bionys-549	114	5	obtained	obtain	VERB
bionys-549	114	6	from	from	ADP
bionys-549	114	7	pdb	pdb	PROPN
bionys-549	114	8	structures	structure	NOUN
bionys-549	114	9	docked	dock	VERB
bionys-549	114	10	into	into	ADP
bionys-549	114	11	the	the	DET
bionys-549	114	12	active	active	ADJ
bionys-549	114	13	site	site	NOUN
bionys-549	114	14	,	,	PUNCT
bionys-549	114	15	making	make	VERB
bionys-549	114	16	80	80	NUM
bionys-549	114	17	%	%	NOUN
bionys-549	114	18	of	of	ADP
bionys-549	114	19	the	the	DET
bionys-549	114	20	interactions	interaction	NOUN
bionys-549	114	21	as	as	ADP
bionys-549	114	22	in	in	ADP
bionys-549	114	23	the	the	DET
bionys-549	114	24	deposited	deposit	VERB
bionys-549	114	25	structures	structure	NOUN
bionys-549	114	26	.	.	PUNCT
bionys-549	115	1	in	in	ADP
bionys-549	115	2	the	the	DET
bionys-549	115	3	case	case	NOUN
bionys-549	115	4	of	of	ADP
bionys-549	115	5	rosmarinic	rosmarinic	ADJ
bionys-549	115	6	acid	acid	NOUN
bionys-549	115	7	,	,	PUNCT
bionys-549	115	8	although	although	SCONJ
bionys-549	115	9	it	it	PRON
bionys-549	115	10	showed	show	VERB
bionys-549	115	11	good	good	ADJ
bionys-549	115	12	interactions	interaction	NOUN
bionys-549	115	13	and	and	CCONJ
bionys-549	115	14	better	well	ADJ
bionys-549	115	15	docking	docking	NOUN
bionys-549	115	16	scores	score	NOUN
bionys-549	115	17	,	,	PUNCT
bionys-549	115	18	its	its	PRON
bionys-549	115	19	size	size	NOUN
bionys-549	115	20	and	and	CCONJ
bionys-549	115	21	biologica	biologica	PROPN
bionys-549	115	22	nyssana	nyssana	PROPN
bionys-549	116	1	●	●	PUNCT
bionys-549	116	2	15	15	NUM
bionys-549	116	3	(	(	PUNCT
bionys-549	116	4	2	2	NUM
bionys-549	116	5	)	)	PUNCT
bionys-549	116	6	december	december	PROPN
bionys-549	116	7	2024	2024	NUM
bionys-549	116	8	:	:	PUNCT
bionys-549	116	9	nagarajan	nagarajan	NOUN
bionys-549	116	10	et	et	PROPN
bionys-549	116	11	al	al	PROPN
bionys-549	116	12	.	.	PUNCT
bionys-549	117	1	●	●	PUNCT
bionys-549	117	2	beyond	beyond	ADP
bionys-549	117	3	boundaries	boundary	NOUN
bionys-549	117	4	:	:	PUNCT
bionys-549	117	5	pioneering	pioneer	VERB
bionys-549	117	6	discoveries	discovery	NOUN
bionys-549	117	7	in	in	ADP
bionys-549	117	8	aldose	aldose	PRON
bionys-549	117	9	reductase	reductase	NOUN
bionys-549	117	10	inhibition	inhibition	NOUN
bionys-549	117	11	for	for	ADP
bionys-549	117	12	diabetic	diabetic	ADJ
bionys-549	117	13	neuropathy	neuropathy	ADJ
bionys-549	117	14	127	127	NUM
bionys-549	117	15	ta	ta	PART
bionys-549	117	16	bl	bl	PROPN
bionys-549	117	17	e	e	PROPN
bionys-549	117	18	1	1	NUM
bionys-549	117	19	.	.	PUNCT
bionys-549	117	20	q	q	PROPN
bionys-549	118	1	ue	ue	PROPN
bionys-549	118	2	rc	rc	PROPN
bionys-549	118	3	et	et	PROPN
bionys-549	118	4	in	in	ADP
bionys-549	118	5	a	a	DET
bionys-549	118	6	na	na	INTJ
bionys-549	118	7	lo	lo	PROPN
bionys-549	118	8	gu	gu	NOUN
bionys-549	118	9	es	es	ADP
bionys-549	118	10	a	a	DET
bionys-549	118	11	nd	nd	ADV
bionys-549	118	12	th	th	X
bionys-549	118	13	ei	ei	ADP
bionys-549	118	14	r	r	VERB
bionys-549	118	15	a	a	PRON
bionys-549	118	16	ct	ct	NOUN
bionys-549	118	17	iv	iv	NOUN
bionys-549	118	18	ity	ity	PROPN
bionys-549	118	19	v	v	PROPN
bionys-549	118	20	al	al	PROPN
bionys-549	118	21	ue	ue	PROPN
bionys-549	118	22	s	s	VERB
bionys-549	118	23	s.	s.	PROPN
bionys-549	118	24	n	n	PROPN
bionys-549	118	25	o.	o.	PROPN
bionys-549	118	26	sc	sc	PROPN
bionys-549	119	1	aff	aff	PROPN
bionys-549	119	2	ol	ol	PROPN
bionys-549	119	3	d	d	PROPN
bionys-549	119	4	su	su	PROPN
bionys-549	119	5	bs	bs	PROPN
bionys-549	119	6	tit	tit	PROPN
bionys-549	119	7	ue	ue	INTJ
bionys-549	120	1	nt	not	PART
bionys-549	120	2	a	a	DET
bionys-549	120	3	ct	ct	NOUN
bionys-549	120	4	iv	iv	NOUN
bionys-549	120	5	ity	ity	PROPN
bionys-549	120	6	[	[	X
bionys-549	120	7	lo	lo	NOUN
bionys-549	120	8	g	g	PROPN
bionys-549	120	9	(	(	PUNCT
bionys-549	120	10	1/	1/	NUM
bionys-549	120	11	ic	ic	NUM
bionys-549	120	12	50	50	NUM
bionys-549	120	13	)	)	PUNCT
bionys-549	120	14	]	]	PUNCT
bionys-549	120	15	µm	µm	ADP
bionys-549	120	16	s.	s.	PROPN
bionys-549	120	17	n	n	PROPN
bionys-549	120	18	o.	o.	PROPN
bionys-549	120	19	sc	sc	PROPN
bionys-549	120	20	aff	aff	PROPN
bionys-549	120	21	ol	ol	PROPN
bionys-549	120	22	d	d	PROPN
bionys-549	120	23	su	su	PROPN
bionys-549	120	24	bs	bs	PROPN
bionys-549	121	1	tit	tit	PROPN
bionys-549	121	2	ue	ue	INTJ
bionys-549	122	1	nt	not	PART
bionys-549	122	2	a	a	DET
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bionys-549	122	4	iv	iv	NOUN
bionys-549	122	5	ity	ity	PROPN
bionys-549	122	6	[	[	X
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bionys-549	122	8	g	g	PROPN
bionys-549	122	9	(	(	PUNCT
bionys-549	122	10	1/	1/	NUM
bionys-549	122	11	ic	ic	NUM
bionys-549	122	12	50	50	NUM
bionys-549	122	13	)	)	PUNCT
bionys-549	122	14	]	]	PUNCT
bionys-549	122	15	µm	µm	ADP
bionys-549	122	16	1	1	NUM
bionys-549	122	17	a	a	DET
bionys-549	122	18	5	5	NUM
bionys-549	122	19	,	,	PUNCT
bionys-549	122	20	7	7	NUM
bionys-549	122	21	,	,	PUNCT
bionys-549	122	22	3	3	NUM
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bionys-549	122	24	,	,	PUNCT
bionys-549	122	25	4	4	NUM
bionys-549	122	26	’	'	PUNCT
bionys-549	122	27	-o	-o	NOUN
bionys-549	122	28	h	h	NOUN
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bionys-549	122	30	3	3	NUM
bionys-549	122	31	,	,	PUNCT
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bionys-549	122	36	3	3	NUM
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bionys-549	122	38	.	.	X
bionys-549	122	39	59	59	NUM
bionys-549	122	40	26	26	NUM
bionys-549	122	41	a	a	DET
bionys-549	122	42	5	5	NUM
bionys-549	122	43	,	,	PUNCT
bionys-549	122	44	6	6	NUM
bionys-549	122	45	,	,	PUNCT
bionys-549	122	46	3	3	NUM
bionys-549	122	47	’	'	PUNCT
bionys-549	122	48	,	,	PUNCT
bionys-549	122	49	4	4	NUM
bionys-549	122	50	’	’	NOUN
bionys-549	122	51	o	o	NOUN
bionys-549	122	52	h	h	NOUN
bionys-549	122	53	;	;	PUNCT
bionys-549	122	54	7	7	NUM
bionys-549	122	55	-o	-o	SYM
bionys-549	122	56	c	c	NOUN
bionys-549	122	57	h	h	NOUN
bionys-549	122	58	3	3	NUM
bionys-549	122	59	6	6	NUM
bionys-549	122	60	.	.	NOUN
bionys-549	122	61	52	52	NUM
bionys-549	122	62	2	2	NUM
bionys-549	122	63	a	a	DET
bionys-549	122	64	3	3	NUM
bionys-549	122	65	’	'	PUNCT
bionys-549	122	66	,	,	PUNCT
bionys-549	122	67	4	4	NUM
bionys-549	122	68	’	’	NOUN
bionys-549	122	69	o	o	NOUN
bionys-549	122	70	h	h	NOUN
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bionys-549	122	72	5	5	NUM
bionys-549	122	73	,	,	PUNCT
bionys-549	122	74	6	6	NUM
bionys-549	122	75	,	,	PUNCT
bionys-549	122	76	7	7	NUM
bionys-549	122	77	,	,	PUNCT
bionys-549	122	78	8	8	NUM
bionys-549	122	79	-o	-o	SYM
bionys-549	122	80	c	c	NOUN
bionys-549	122	81	h	h	NOUN
bionys-549	123	1	3	3	NUM
bionys-549	123	2	7	7	NUM
bionys-549	123	3	.	.	NUM
bionys-549	123	4	49	49	NUM
bionys-549	123	5	27	27	NUM
bionys-549	123	6	a	a	DET
bionys-549	123	7	6	6	NUM
bionys-549	123	8	,	,	PUNCT
bionys-549	123	9	3	3	NUM
bionys-549	123	10	’	'	PUNCT
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bionys-549	123	12	4	4	NUM
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bionys-549	123	17	3	3	NUM
bionys-549	123	18	,	,	PUNCT
bionys-549	123	19	5	5	NUM
bionys-549	123	20	,	,	PUNCT
bionys-549	123	21	7	7	NUM
bionys-549	123	22	-o	-o	SYM
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bionys-549	123	24	h	h	NOUN
bionys-549	123	25	3	3	NUM
bionys-549	123	26	6	6	NUM
bionys-549	123	27	.	.	PUNCT
bionys-549	123	28	52	52	NUM
bionys-549	123	29	3	3	NUM
bionys-549	123	30	a	a	DET
bionys-549	123	31	6	6	NUM
bionys-549	123	32	,	,	PUNCT
bionys-549	123	33	3	3	NUM
bionys-549	123	34	’	'	PUNCT
bionys-549	123	35	,	,	PUNCT
bionys-549	123	36	4	4	NUM
bionys-549	123	37	’	’	NOUN
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bionys-549	123	40	;	;	PUNCT
bionys-549	123	41	5	5	NUM
bionys-549	123	42	,	,	PUNCT
bionys-549	123	43	7	7	NUM
bionys-549	123	44	,	,	PUNCT
bionys-549	123	45	8	8	NUM
bionys-549	123	46	-o	-o	SYM
bionys-549	123	47	c	c	NOUN
bionys-549	123	48	h	h	NOUN
bionys-549	123	49	3	3	NUM
bionys-549	123	50	7	7	NUM
bionys-549	123	51	.	.	NUM
bionys-549	123	52	44	44	NUM
bionys-549	123	53	28	28	NUM
bionys-549	123	54	a	a	DET
bionys-549	123	55	5	5	NUM
bionys-549	123	56	,	,	PUNCT
bionys-549	123	57	3	3	NUM
bionys-549	123	58	’	'	PUNCT
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bionys-549	123	60	4	4	NUM
bionys-549	123	61	’	’	NOUN
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bionys-549	123	74	6	6	NUM
bionys-549	123	75	.	.	PUNCT
bionys-549	123	76	46	46	NUM
bionys-549	123	77	4	4	NUM
bionys-549	123	78	a	a	DET
bionys-549	123	79	5	5	NUM
bionys-549	123	80	,	,	PUNCT
bionys-549	123	81	7	7	NUM
bionys-549	123	82	,	,	PUNCT
bionys-549	123	83	3	3	NUM
bionys-549	123	84	’	'	PUNCT
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bionys-549	123	86	4	4	NUM
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bionys-549	123	89	h	h	NOUN
bionys-549	123	90	;	;	PUNCT
bionys-549	123	91	6	6	NUM
bionys-549	123	92	-o	-o	SYM
bionys-549	123	93	c	c	NOUN
bionys-549	123	94	h	h	NOUN
bionys-549	123	95	3	3	NUM
bionys-549	123	96	;	;	PUNCT
bionys-549	123	97	8c	8c	NUM
bionys-549	123	98	h	h	NOUN
bionys-549	123	99	2p	2p	NUM
bionys-549	123	100	h	h	NOUN
bionys-549	123	101	7	7	NUM
bionys-549	123	102	.	.	X
bionys-549	123	103	47	47	NUM
bionys-549	123	104	29	29	NUM
bionys-549	123	105	a	a	DET
bionys-549	123	106	5	5	NUM
bionys-549	123	107	,	,	PUNCT
bionys-549	123	108	7	7	NUM
bionys-549	123	109	,	,	PUNCT
bionys-549	123	110	4	4	NUM
bionys-549	123	111	’	'	PUNCT
bionys-549	123	112	-o	-o	NOUN
bionys-549	123	113	h	h	NOUN
bionys-549	123	114	;	;	PUNCT
bionys-549	123	115	6	6	NUM
bionys-549	123	116	,	,	PUNCT
bionys-549	123	117	8	8	NUM
bionys-549	123	118	-o	-o	SYM
bionys-549	123	119	c	c	NOUN
bionys-549	123	120	h	h	NOUN
bionys-549	123	121	3	3	NUM
bionys-549	123	122	6	6	NUM
bionys-549	123	123	.	.	PUNCT
bionys-549	123	124	39	39	NUM
bionys-549	123	125	5	5	NUM
bionys-549	123	126	a	a	DET
bionys-549	123	127	5	5	NUM
bionys-549	123	128	,	,	PUNCT
bionys-549	123	129	3	3	NUM
bionys-549	123	130	’	'	PUNCT
bionys-549	123	131	,	,	PUNCT
bionys-549	123	132	4	4	NUM
bionys-549	123	133	’	’	NOUN
bionys-549	123	134	o	o	NOUN
bionys-549	123	135	h	h	NOUN
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bionys-549	123	137	6	6	NUM
bionys-549	123	138	,	,	PUNCT
bionys-549	123	139	7	7	NUM
bionys-549	123	140	,	,	PUNCT
bionys-549	123	141	8	8	NUM
bionys-549	123	142	-o	-o	SYM
bionys-549	123	143	c	c	NOUN
bionys-549	123	144	h	h	NOUN
bionys-549	123	145	3	3	NUM
bionys-549	123	146	7	7	NUM
bionys-549	123	147	.	.	PUNCT
bionys-549	123	148	41	41	NUM
bionys-549	123	149	30	30	NUM
bionys-549	123	150	a	a	DET
bionys-549	123	151	5	5	NUM
bionys-549	123	152	,	,	PUNCT
bionys-549	123	153	4	4	NUM
bionys-549	123	154	’	'	PUNCT
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bionys-549	123	161	,	,	PUNCT
bionys-549	123	162	8	8	NUM
bionys-549	123	163	-o	-o	SYM
bionys-549	123	164	c	c	NOUN
bionys-549	123	165	h	h	NOUN
bionys-549	123	166	3	3	NUM
bionys-549	123	167	6	6	NUM
bionys-549	123	168	.	.	PUNCT
bionys-549	123	169	27	27	NUM
bionys-549	123	170	6	6	NUM
bionys-549	123	171	a	a	DET
bionys-549	123	172	3	3	NUM
bionys-549	123	173	’	'	PUNCT
bionys-549	123	174	,	,	PUNCT
bionys-549	123	175	4	4	NUM
bionys-549	123	176	’	’	NOUN
bionys-549	123	177	o	o	NOUN
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bionys-549	123	180	5	5	NUM
bionys-549	123	181	,	,	PUNCT
bionys-549	123	182	7	7	NUM
bionys-549	123	183	,	,	PUNCT
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bionys-549	123	189	7	7	NUM
bionys-549	123	190	.	.	NUM
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bionys-549	123	193	a	a	DET
bionys-549	123	194	5	5	NUM
bionys-549	123	195	,	,	PUNCT
bionys-549	123	196	6	6	NUM
bionys-549	123	197	,	,	PUNCT
bionys-549	123	198	3	3	NUM
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bionys-549	123	216	7	7	NUM
bionys-549	123	217	a	a	DET
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bionys-549	123	219	,	,	PUNCT
bionys-549	123	220	6	6	NUM
bionys-549	123	221	,	,	PUNCT
bionys-549	123	222	7	7	NUM
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bionys-549	123	224	3	3	NUM
bionys-549	123	225	’	'	PUNCT
bionys-549	123	226	,	,	PUNCT
bionys-549	123	227	4	4	NUM
bionys-549	123	228	’	’	NOUN
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bionys-549	123	240	32	32	NUM
bionys-549	123	241	a	a	DET
bionys-549	123	242	3	3	NUM
bionys-549	123	243	,	,	PUNCT
bionys-549	123	244	5	5	NUM
bionys-549	123	245	,	,	PUNCT
bionys-549	123	246	7	7	NUM
bionys-549	123	247	,	,	PUNCT
bionys-549	123	248	3	3	NUM
bionys-549	123	249	’	'	PUNCT
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bionys-549	123	251	4	4	NUM
bionys-549	123	252	’	’	NOUN
bionys-549	123	253	o	o	NOUN
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bionys-549	123	257	02	02	NUM
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bionys-549	123	259	a	a	DET
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bionys-549	123	261	,	,	PUNCT
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bionys-549	123	273	,	,	PUNCT
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bionys-549	123	279	7	7	NUM
bionys-549	123	280	.	.	NOUN
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bionys-549	123	282	33	33	NUM
bionys-549	123	283	a	a	DET
bionys-549	123	284	5	5	NUM
bionys-549	123	285	,	,	PUNCT
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bionys-549	123	301	.	.	NOUN
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bionys-549	123	304	a	a	DET
bionys-549	123	305	7	7	NUM
bionys-549	123	306	,	,	PUNCT
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bionys-549	123	316	,	,	PUNCT
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bionys-549	123	319	c	c	NOUN
bionys-549	123	320	h	h	NOUN
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bionys-549	123	322	7	7	NUM
bionys-549	123	323	.	.	SYM
bionys-549	123	324	13	13	NUM
bionys-549	123	325	34	34	NUM
bionys-549	123	326	a	a	DET
bionys-549	123	327	5	5	NUM
bionys-549	123	328	,	,	PUNCT
bionys-549	123	329	6	6	NUM
bionys-549	123	330	,	,	PUNCT
bionys-549	123	331	7	7	NUM
bionys-549	123	332	,	,	PUNCT
bionys-549	123	333	4	4	NUM
bionys-549	123	334	’	'	PUNCT
bionys-549	123	335	-o	-o	NOUN
bionys-549	123	336	h	h	NOUN
bionys-549	123	337	;	;	PUNCT
bionys-549	123	338	8	8	NUM
bionys-549	123	339	-o	-o	SYM
bionys-549	123	340	c	c	NOUN
bionys-549	123	341	h	h	NOUN
bionys-549	123	342	3	3	NUM
bionys-549	123	343	5	5	NUM
bionys-549	123	344	.	.	PUNCT
bionys-549	123	345	92	92	NUM
bionys-549	123	346	10	10	NUM
bionys-549	123	347	a	a	DET
bionys-549	123	348	5	5	NUM
bionys-549	123	349	,	,	PUNCT
bionys-549	123	350	3	3	NUM
bionys-549	123	351	’	'	PUNCT
bionys-549	123	352	,	,	PUNCT
bionys-549	123	353	4	4	NUM
bionys-549	123	354	’	’	NOUN
bionys-549	123	355	o	o	NOUN
bionys-549	123	356	h	h	NOUN
bionys-549	123	357	;	;	PUNCT
bionys-549	123	358	7	7	NUM
bionys-549	123	359	,	,	PUNCT
bionys-549	123	360	8	8	NUM
bionys-549	123	361	-o	-o	SYM
bionys-549	123	362	c	c	NOUN
bionys-549	123	363	h	h	NOUN
bionys-549	123	364	3	3	NUM
bionys-549	123	365	7	7	NUM
bionys-549	123	366	.	.	SYM
bionys-549	123	367	11	11	NUM
bionys-549	123	368	35	35	NUM
bionys-549	123	369	a	a	DET
bionys-549	123	370	5	5	NUM
bionys-549	123	371	,	,	PUNCT
bionys-549	123	372	6	6	NUM
bionys-549	123	373	,	,	PUNCT
bionys-549	123	374	7	7	NUM
bionys-549	123	375	,	,	PUNCT
bionys-549	123	376	4	4	NUM
bionys-549	123	377	’	'	PUNCT
bionys-549	123	378	-o	-o	NOUN
bionys-549	123	379	h	h	NOUN
bionys-549	123	380	;	;	PUNCT
bionys-549	123	381	8	8	NUM
bionys-549	123	382	,	,	PUNCT
bionys-549	123	383	3	3	NUM
bionys-549	123	384	’	'	PUNCT
bionys-549	123	385	o	o	NOUN
bionys-549	123	386	c	c	NOUN
bionys-549	123	387	h	h	NOUN
bionys-549	123	388	3	3	NUM
bionys-549	123	389	5	5	NUM
bionys-549	123	390	.	.	PUNCT
bionys-549	123	391	92	92	NUM
bionys-549	123	392	11	11	NUM
bionys-549	123	393	a	a	DET
bionys-549	123	394	3	3	NUM
bionys-549	123	395	,	,	PUNCT
bionys-549	123	396	'	'	NUM
bionys-549	123	397	4	4	NUM
bionys-549	123	398	’	’	NOUN
bionys-549	123	399	o	o	NOUN
bionys-549	123	400	h	h	NOUN
bionys-549	123	401	;	;	PUNCT
bionys-549	123	402	5	5	NUM
bionys-549	123	403	,	,	PUNCT
bionys-549	123	404	6	6	NUM
bionys-549	123	405	,	,	PUNCT
bionys-549	123	406	7	7	NUM
bionys-549	123	407	-o	-o	SYM
bionys-549	123	408	c	c	NOUN
bionys-549	123	409	h	h	NOUN
bionys-549	123	410	3	3	NUM
bionys-549	123	411	7	7	NUM
bionys-549	123	412	.	.	PUNCT
bionys-549	123	413	04	04	NUM
bionys-549	123	414	36	36	NUM
bionys-549	123	415	a	a	DET
bionys-549	123	416	5	5	NUM
bionys-549	123	417	,	,	PUNCT
bionys-549	123	418	4	4	NUM
bionys-549	123	419	’	'	PUNCT
bionys-549	123	420	-o	-o	NOUN
bionys-549	123	421	h	h	NOUN
bionys-549	123	422	;	;	PUNCT
bionys-549	123	423	6	6	NUM
bionys-549	123	424	,	,	PUNCT
bionys-549	123	425	7	7	NUM
bionys-549	123	426	-o	-o	SYM
bionys-549	123	427	c	c	NOUN
bionys-549	123	428	h	h	NOUN
bionys-549	123	429	3	3	NUM
bionys-549	123	430	5	5	NUM
bionys-549	123	431	.	.	NOUN
bionys-549	123	432	85	85	NUM
bionys-549	123	433	12	12	NUM
bionys-549	123	434	a	a	DET
bionys-549	123	435	5	5	NUM
bionys-549	123	436	,	,	PUNCT
bionys-549	123	437	6	6	NUM
bionys-549	123	438	,	,	PUNCT
bionys-549	123	439	7	7	NUM
bionys-549	123	440	,	,	PUNCT
bionys-549	123	441	3	3	NUM
bionys-549	123	442	’	'	PUNCT
bionys-549	123	443	,	,	PUNCT
bionys-549	123	444	4	4	NUM
bionys-549	123	445	’	’	NOUN
bionys-549	123	446	o	o	NOUN
bionys-549	123	447	h	h	NOUN
bionys-549	123	448	;	;	PUNCT
bionys-549	123	449	8	8	NUM
bionys-549	123	450	-o	-o	SYM
bionys-549	123	451	c	c	NOUN
bionys-549	123	452	h	h	NOUN
bionys-549	123	453	3	3	NUM
bionys-549	123	454	6	6	NUM
bionys-549	123	455	.	.	PUNCT
bionys-549	124	1	92	92	NUM
bionys-549	124	2	37	37	NUM
bionys-549	124	3	a	a	DET
bionys-549	124	4	5	5	NUM
bionys-549	124	5	,	,	PUNCT
bionys-549	124	6	7	7	NUM
bionys-549	124	7	,	,	PUNCT
bionys-549	124	8	3	3	NUM
bionys-549	124	9	’	'	PUNCT
bionys-549	124	10	,	,	PUNCT
bionys-549	124	11	4	4	NUM
bionys-549	124	12	’	’	NOUN
bionys-549	124	13	o	o	NOUN
bionys-549	124	14	h	h	NOUN
bionys-549	124	15	;	;	PUNCT
bionys-549	124	16	3	3	X
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bionys-549	124	18	-r	-r	NUM
bionys-549	124	19	h	h	NOUN
bionys-549	124	20	6	6	NUM
bionys-549	124	21	.	.	PUNCT
bionys-549	124	22	54	54	NUM
bionys-549	124	23	13	13	NUM
bionys-549	124	24	a	a	DET
bionys-549	124	25	6	6	NUM
bionys-549	124	26	,	,	PUNCT
bionys-549	124	27	3	3	NUM
bionys-549	124	28	’	'	PUNCT
bionys-549	124	29	,	,	PUNCT
bionys-549	124	30	4	4	NUM
bionys-549	124	31	’	’	NOUN
bionys-549	124	32	o	o	NOUN
bionys-549	124	33	h	h	NOUN
bionys-549	124	34	;	;	PUNCT
bionys-549	124	35	5	5	NUM
bionys-549	124	36	,	,	PUNCT
bionys-549	124	37	7	7	NUM
bionys-549	124	38	-o	-o	SYM
bionys-549	124	39	c	c	NOUN
bionys-549	124	40	h	h	NOUN
bionys-549	124	41	3	3	NUM
bionys-549	124	42	6	6	NUM
bionys-549	124	43	.	.	NUM
bionys-549	124	44	85	85	NUM
bionys-549	124	45	38	38	NUM
bionys-549	124	46	a	a	DET
bionys-549	124	47	5	5	NUM
bionys-549	124	48	,	,	PUNCT
bionys-549	124	49	7	7	NUM
bionys-549	124	50	,	,	PUNCT
bionys-549	124	51	4	4	NUM
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bionys-549	124	53	-o	-o	NOUN
bionys-549	124	54	h	h	NOUN
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bionys-549	124	57	,	,	PUNCT
bionys-549	124	58	8	8	NUM
bionys-549	124	59	,	,	PUNCT
bionys-549	124	60	3	3	NUM
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bionys-549	124	62	o	o	NOUN
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bionys-549	124	70	a	a	DET
bionys-549	124	71	4	4	NUM
bionys-549	124	72	’	'	PUNCT
bionys-549	124	73	-o	-o	NOUN
bionys-549	124	74	h	h	NOUN
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bionys-549	124	76	5	5	NUM
bionys-549	124	77	,	,	PUNCT
bionys-549	124	78	6	6	NUM
bionys-549	124	79	,	,	PUNCT
bionys-549	124	80	7	7	NUM
bionys-549	124	81	,	,	PUNCT
bionys-549	124	82	8	8	NUM
bionys-549	124	83	-o	-o	SYM
bionys-549	124	84	c	c	NOUN
bionys-549	124	85	h	h	NOUN
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bionys-549	124	87	6	6	NUM
bionys-549	124	88	.	.	PUNCT
bionys-549	124	89	79	79	NUM
bionys-549	124	90	39	39	NUM
bionys-549	124	91	a	a	DET
bionys-549	124	92	6	6	NUM
bionys-549	124	93	,	,	PUNCT
bionys-549	124	94	4	4	NUM
bionys-549	124	95	’	'	PUNCT
bionys-549	124	96	-o	-o	NOUN
bionys-549	124	97	h	h	NOUN
bionys-549	124	98	;	;	PUNCT
bionys-549	124	99	5	5	NUM
bionys-549	124	100	,	,	PUNCT
bionys-549	124	101	7	7	NUM
bionys-549	124	102	,	,	PUNCT
bionys-549	124	103	8	8	NUM
bionys-549	124	104	,	,	PUNCT
bionys-549	124	105	3	3	NUM
bionys-549	124	106	’	'	PUNCT
bionys-549	124	107	o	o	NOUN
bionys-549	124	108	c	c	NOUN
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bionys-549	124	112	.	.	SYM
bionys-549	124	113	2	2	NUM
bionys-549	124	114	15	15	NUM
bionys-549	124	115	a	a	DET
bionys-549	124	116	8	8	NUM
bionys-549	124	117	,	,	PUNCT
bionys-549	124	118	3	3	NUM
bionys-549	124	119	’	'	PUNCT
bionys-549	124	120	,	,	PUNCT
bionys-549	124	121	4	4	NUM
bionys-549	124	122	’	’	NOUN
bionys-549	124	123	o	o	NOUN
bionys-549	124	124	h	h	NOUN
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bionys-549	124	126	5	5	NUM
bionys-549	124	127	,	,	PUNCT
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bionys-549	124	129	-o	-o	SYM
bionys-549	124	130	c	c	NOUN
bionys-549	124	131	h	h	NOUN
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bionys-549	124	134	.	.	PUNCT
bionys-549	125	1	79	79	NUM
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bionys-549	125	4	5	5	NUM
bionys-549	125	5	,	,	PUNCT
bionys-549	125	6	4	4	NUM
bionys-549	125	7	’	'	PUNCT
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bionys-549	125	15	3	3	NUM
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bionys-549	125	17	o	o	NOUN
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bionys-549	125	21	5	5	NUM
bionys-549	125	22	.	.	PUNCT
bionys-549	125	23	17	17	NUM
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bionys-549	125	25	a	a	DET
bionys-549	125	26	3	3	NUM
bionys-549	125	27	’	'	PUNCT
bionys-549	125	28	,	,	PUNCT
bionys-549	125	29	4	4	NUM
bionys-549	125	30	’	’	NOUN
bionys-549	125	31	o	o	NOUN
bionys-549	125	32	h	h	NOUN
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bionys-549	125	34	3	3	NUM
bionys-549	125	35	,	,	PUNCT
bionys-549	125	36	5	5	NUM
bionys-549	125	37	,	,	PUNCT
bionys-549	125	38	7	7	NUM
bionys-549	125	39	,	,	PUNCT
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bionys-549	125	42	c	c	NOUN
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bionys-549	125	44	3	3	NUM
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bionys-549	125	46	.	.	PUNCT
bionys-549	126	1	77	77	NUM
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bionys-549	126	4	5	5	NUM
bionys-549	126	5	,	,	PUNCT
bionys-549	126	6	7o	7o	NUM
bionys-549	126	7	h	h	NOUN
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bionys-549	126	10	,	,	PUNCT
bionys-549	126	11	8	8	NUM
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bionys-549	126	13	4	4	NUM
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bionys-549	126	20	.	.	PUNCT
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bionys-549	126	23	a	a	DET
bionys-549	126	24	5	5	NUM
bionys-549	126	25	,	,	PUNCT
bionys-549	126	26	6	6	NUM
bionys-549	126	27	,	,	PUNCT
bionys-549	126	28	7	7	NUM
bionys-549	126	29	,	,	PUNCT
bionys-549	126	30	3	3	NUM
bionys-549	126	31	’	'	PUNCT
bionys-549	126	32	,	,	PUNCT
bionys-549	126	33	4	4	NUM
bionys-549	126	34	’	’	NOUN
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bionys-549	126	36	h	h	NOUN
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bionys-549	126	38	.	.	PUNCT
bionys-549	126	39	69	69	NUM
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bionys-549	126	41	a	a	DET
bionys-549	126	42	5	5	NUM
bionys-549	126	43	,	,	PUNCT
bionys-549	126	44	6	6	NUM
bionys-549	126	45	,	,	PUNCT
bionys-549	126	46	7o	7o	NUM
bionys-549	126	47	h	h	NOUN
bionys-549	126	48	;	;	PUNCT
bionys-549	126	49	8	8	NUM
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bionys-549	126	52	h	h	NOUN
bionys-549	126	53	3	3	NUM
bionys-549	126	54	5	5	NUM
bionys-549	126	55	.	.	PUNCT
bionys-549	126	56	09	09	NUM
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bionys-549	126	58	a	a	DET
bionys-549	126	59	5	5	NUM
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bionys-549	126	61	3	3	NUM
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bionys-549	127	1	92	92	NUM
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bionys-549	127	4	5	5	NUM
bionys-549	127	5	,	,	PUNCT
bionys-549	127	6	6o	6o	NUM
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bionys-549	127	20	a	a	DET
bionys-549	127	21	5	5	NUM
bionys-549	127	22	,	,	PUNCT
bionys-549	127	23	8	8	NUM
bionys-549	127	24	,	,	PUNCT
bionys-549	127	25	3	3	NUM
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bionys-549	127	27	,	,	PUNCT
bionys-549	127	28	4	4	NUM
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bionys-549	127	32	;	;	PUNCT
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bionys-549	127	39	.	.	PUNCT
bionys-549	127	40	64	64	NUM
bionys-549	127	41	44	44	NUM
bionys-549	127	42	a	a	DET
bionys-549	127	43	3	3	NUM
bionys-549	127	44	’	'	PUNCT
bionys-549	127	45	,	,	PUNCT
bionys-549	127	46	4	4	NUM
bionys-549	127	47	’	’	NOUN
bionys-549	127	48	o	o	NOUN
bionys-549	127	49	h	h	NOUN
bionys-549	127	50	;	;	PUNCT
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bionys-549	127	52	,	,	PUNCT
bionys-549	127	53	6	6	NUM
bionys-549	127	54	,	,	PUNCT
bionys-549	127	55	7	7	NUM
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bionys-549	127	57	c	c	NOUN
bionys-549	127	58	h	h	NOUN
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bionys-549	127	60	;	;	PUNCT
bionys-549	128	1	3c	3c	NUM
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bionys-549	128	3	c	c	NOUN
bionys-549	128	4	h	h	NOUN
bionys-549	128	5	3	3	NUM
bionys-549	128	6	5	5	NUM
bionys-549	128	7	.	.	PUNCT
bionys-549	128	8	05	05	NUM
bionys-549	128	9	20	20	NUM
bionys-549	128	10	a	a	DET
bionys-549	128	11	5	5	NUM
bionys-549	128	12	,	,	PUNCT
bionys-549	128	13	7	7	NUM
bionys-549	128	14	,	,	PUNCT
bionys-549	128	15	3	3	NUM
bionys-549	128	16	’	'	PUNCT
bionys-549	128	17	,	,	PUNCT
bionys-549	128	18	4	4	NUM
bionys-549	128	19	’	’	NOUN
bionys-549	128	20	o	o	NOUN
bionys-549	128	21	h	h	NOUN
bionys-549	128	22	;	;	PUNCT
bionys-549	128	23	3	3	NUM
bionys-549	128	24	,	,	PUNCT
bionys-549	128	25	8	8	NUM
bionys-549	128	26	-o	-o	SYM
bionys-549	128	27	c	c	NOUN
bionys-549	128	28	h	h	NOUN
bionys-549	128	29	3	3	NUM
bionys-549	128	30	6	6	NUM
bionys-549	128	31	.	.	PUNCT
bionys-549	129	1	62	62	NUM
bionys-549	129	2	45	45	NUM
bionys-549	129	3	a	a	DET
bionys-549	129	4	5	5	NUM
bionys-549	129	5	,	,	PUNCT
bionys-549	129	6	3	3	NUM
bionys-549	129	7	’	'	PUNCT
bionys-549	129	8	-o	-o	NOUN
bionys-549	129	9	h	h	NOUN
bionys-549	129	10	;	;	PUNCT
bionys-549	129	11	6	6	NUM
bionys-549	129	12	,	,	PUNCT
bionys-549	129	13	7	7	NUM
bionys-549	129	14	-o	-o	SYM
bionys-549	129	15	c	c	NOUN
bionys-549	129	16	h	h	NOUN
bionys-549	129	17	3	3	NUM
bionys-549	129	18	;	;	PUNCT
bionys-549	129	19	4	4	NUM
bionys-549	129	20	’	'	PUNCT
bionys-549	129	21	-o	-o	INTJ
bionys-549	130	1	-g	-g	PUNCT
bionys-549	130	2	lc	lc	PROPN
bionys-549	130	3	5	5	NUM
bionys-549	130	4	.	.	PROPN
bionys-549	130	5	09	09	NUM
bionys-549	130	6	21	21	NUM
bionys-549	130	7	a	a	DET
bionys-549	130	8	6	6	NUM
bionys-549	130	9	,	,	PUNCT
bionys-549	130	10	4	4	NUM
bionys-549	130	11	’	'	PUNCT
bionys-549	130	12	-o	-o	NOUN
bionys-549	130	13	h	h	NOUN
bionys-549	130	14	;	;	PUNCT
bionys-549	130	15	5	5	NUM
bionys-549	130	16	,	,	PUNCT
bionys-549	130	17	7	7	NUM
bionys-549	130	18	,	,	PUNCT
bionys-549	130	19	8	8	NUM
bionys-549	130	20	-o	-o	SYM
bionys-549	130	21	c	c	NOUN
bionys-549	130	22	h	h	NOUN
bionys-549	130	23	3	3	NUM
bionys-549	130	24	6	6	NUM
bionys-549	130	25	.	.	NOUN
bionys-549	130	26	6	6	NUM
bionys-549	130	27	46	46	NUM
bionys-549	130	28	a	a	DET
bionys-549	130	29	5o	5o	PROPN
bionys-549	130	30	h	h	NOUN
bionys-549	130	31	;	;	PUNCT
bionys-549	130	32	6	6	NUM
bionys-549	130	33	,	,	PUNCT
bionys-549	130	34	7	7	NUM
bionys-549	130	35	,	,	PUNCT
bionys-549	130	36	3	3	NUM
bionys-549	130	37	’	'	PUNCT
bionys-549	130	38	o	o	NOUN
bionys-549	130	39	c	c	NOUN
bionys-549	130	40	h	h	NOUN
bionys-549	130	41	3	3	NUM
bionys-549	130	42	;	;	PUNCT
bionys-549	130	43	4	4	NUM
bionys-549	130	44	’	'	PUNCT
bionys-549	130	45	-o	-o	INTJ
bionys-549	130	46	-g	-g	PUNCT
bionys-549	130	47	lc	lc	PROPN
bionys-549	130	48	4	4	NUM
bionys-549	130	49	.	.	PROPN
bionys-549	130	50	6	6	NUM
bionys-549	130	51	22	22	NUM
bionys-549	130	52	a	a	DET
bionys-549	130	53	3	3	NUM
bionys-549	130	54	’	'	PUNCT
bionys-549	130	55	,	,	PUNCT
bionys-549	130	56	4	4	NUM
bionys-549	130	57	’	’	NOUN
bionys-549	130	58	o	o	NOUN
bionys-549	130	59	h	h	NOUN
bionys-549	130	60	;	;	PUNCT
bionys-549	130	61	5	5	NUM
bionys-549	130	62	,	,	PUNCT
bionys-549	130	63	6	6	NUM
bionys-549	130	64	,	,	PUNCT
bionys-549	130	65	7	7	NUM
bionys-549	130	66	-o	-o	SYM
bionys-549	130	67	c	c	NOUN
bionys-549	130	68	h	h	NOUN
bionys-549	130	69	3	3	NUM
bionys-549	130	70	6	6	NUM
bionys-549	130	71	.	.	PUNCT
bionys-549	130	72	57	57	NUM
bionys-549	130	73	47	47	NUM
bionys-549	130	74	a	a	DET
bionys-549	130	75	5o	5o	PROPN
bionys-549	130	76	h	h	NOUN
bionys-549	130	77	;	;	PUNCT
bionys-549	130	78	6	6	NUM
bionys-549	130	79	,	,	PUNCT
bionys-549	130	80	7	7	NUM
bionys-549	130	81	-o	-o	SYM
bionys-549	130	82	c	c	NOUN
bionys-549	130	83	h	h	NOUN
bionys-549	130	84	3	3	NUM
bionys-549	130	85	;	;	PUNCT
bionys-549	130	86	4	4	NUM
bionys-549	130	87	’	'	PUNCT
bionys-549	130	88	-o	-o	INTJ
bionys-549	130	89	-g	-g	PUNCT
bionys-549	130	90	lc	lc	PROPN
bionys-549	130	91	4	4	NUM
bionys-549	130	92	.	.	NOUN
bionys-549	130	93	6	6	NUM
bionys-549	130	94	23	23	NUM
bionys-549	130	95	a	a	DET
bionys-549	130	96	5	5	NUM
bionys-549	130	97	,	,	PUNCT
bionys-549	130	98	7	7	NUM
bionys-549	130	99	,	,	PUNCT
bionys-549	130	100	3	3	NUM
bionys-549	130	101	’	'	PUNCT
bionys-549	130	102	,	,	PUNCT
bionys-549	130	103	4	4	NUM
bionys-549	130	104	’	’	NOUN
bionys-549	130	105	o	o	NOUN
bionys-549	130	106	h	h	NOUN
bionys-549	130	107	;	;	PUNCT
bionys-549	130	108	8	8	NUM
bionys-549	130	109	-o	-o	SYM
bionys-549	130	110	c	c	NOUN
bionys-549	130	111	h	h	NOUN
bionys-549	130	112	3	3	NUM
bionys-549	130	113	6	6	NUM
bionys-549	130	114	.	.	PUNCT
bionys-549	130	115	55	55	NUM
bionys-549	130	116	48	48	NUM
bionys-549	130	117	a	a	DET
bionys-549	130	118	5	5	NUM
bionys-549	130	119	,	,	PUNCT
bionys-549	130	120	7o	7o	NUM
bionys-549	130	121	h	h	NOUN
bionys-549	130	122	;	;	PUNCT
bionys-549	130	123	6	6	NUM
bionys-549	130	124	,	,	PUNCT
bionys-549	130	125	8	8	NUM
bionys-549	130	126	,	,	PUNCT
bionys-549	130	127	3	3	NUM
bionys-549	130	128	’	'	PUNCT
bionys-549	130	129	o	o	NOUN
bionys-549	130	130	c	c	NOUN
bionys-549	130	131	h	h	NOUN
bionys-549	130	132	3	3	NUM
bionys-549	130	133	;	;	PUNCT
bionys-549	130	134	4	4	NUM
bionys-549	130	135	’	'	PUNCT
bionys-549	130	136	-o	-o	INTJ
bionys-549	130	137	-g	-g	PUNCT
bionys-549	130	138	lc	lc	PROPN
bionys-549	130	139	4	4	NUM
bionys-549	130	140	.	.	PUNCT
bionys-549	130	141	33	33	NUM
bionys-549	130	142	24	24	NUM
bionys-549	130	143	a	a	DET
bionys-549	130	144	7	7	NUM
bionys-549	130	145	,	,	PUNCT
bionys-549	130	146	3	3	NUM
bionys-549	130	147	’	'	PUNCT
bionys-549	130	148	,	,	PUNCT
bionys-549	130	149	4	4	NUM
bionys-549	130	150	’	’	NOUN
bionys-549	130	151	o	o	NOUN
bionys-549	130	152	h	h	NOUN
bionys-549	130	153	;	;	PUNCT
bionys-549	130	154	3	3	NUM
bionys-549	130	155	,	,	PUNCT
bionys-549	130	156	5	5	NUM
bionys-549	130	157	,	,	PUNCT
bionys-549	130	158	8	8	NUM
bionys-549	130	159	-o	-o	SYM
bionys-549	130	160	c	c	NOUN
bionys-549	130	161	h	h	NOUN
bionys-549	130	162	3	3	NUM
bionys-549	130	163	6	6	NUM
bionys-549	130	164	.	.	PUNCT
bionys-549	130	165	55	55	NUM
bionys-549	130	166	49	49	NUM
bionys-549	130	167	a	a	DET
bionys-549	130	168	4	4	NUM
bionys-549	130	169	’	'	PUNCT
bionys-549	130	170	-o	-o	NOUN
bionys-549	130	171	h	h	NOUN
bionys-549	130	172	;	;	PUNCT
bionys-549	130	173	5	5	NUM
bionys-549	130	174	,	,	PUNCT
bionys-549	130	175	6	6	NUM
bionys-549	130	176	,	,	PUNCT
bionys-549	130	177	7	7	NUM
bionys-549	130	178	,	,	PUNCT
bionys-549	130	179	8	8	NUM
bionys-549	130	180	,	,	PUNCT
bionys-549	130	181	3	3	NUM
bionys-549	130	182	’	'	PUNCT
bionys-549	130	183	o	o	NOUN
bionys-549	130	184	c	c	NOUN
bionys-549	130	185	h	h	NOUN
bionys-549	130	186	3	3	NUM
bionys-549	130	187	4	4	NUM
bionys-549	130	188	.	.	X
bionys-549	130	189	74	74	NUM
bionys-549	130	190	25	25	NUM
bionys-549	130	191	a	a	DET
bionys-549	130	192	8o	8o	NUM
bionys-549	130	193	c	c	NOUN
bionys-549	130	194	h	h	NOUN
bionys-549	130	195	3	3	NUM
bionys-549	130	196	;	;	PUNCT
bionys-549	130	197	5	5	NUM
bionys-549	130	198	,	,	PUNCT
bionys-549	130	199	6	6	NUM
bionys-549	130	200	,	,	PUNCT
bionys-549	130	201	7	7	NUM
bionys-549	130	202	,	,	PUNCT
bionys-549	130	203	3	3	NUM
bionys-549	130	204	’	'	PUNCT
bionys-549	130	205	,	,	PUNCT
bionys-549	130	206	4	4	NUM
bionys-549	130	207	’	’	NOUN
bionys-549	130	208	o	o	NOUN
bionys-549	131	1	c	c	NOUN
bionys-549	131	2	o	o	NOUN
bionys-549	131	3	c	c	NOUN
bionys-549	131	4	h	h	NOUN
bionys-549	131	5	3	3	NUM
bionys-549	131	6	6	6	NUM
bionys-549	131	7	.	.	PUNCT
bionys-549	131	8	52	52	NUM
bionys-549	131	9	50	50	NUM
bionys-549	131	10	a	a	DET
bionys-549	131	11	5	5	NUM
bionys-549	131	12	,	,	PUNCT
bionys-549	131	13	4	4	NUM
bionys-549	131	14	’	'	PUNCT
bionys-549	131	15	-o	-o	NOUN
bionys-549	131	16	h	h	NOUN
bionys-549	131	17	;	;	PUNCT
bionys-549	131	18	6	6	NUM
bionys-549	131	19	,	,	PUNCT
bionys-549	131	20	8	8	NUM
bionys-549	131	21	,	,	PUNCT
bionys-549	131	22	3	3	NUM
bionys-549	131	23	’	'	PUNCT
bionys-549	131	24	o	o	NOUN
bionys-549	131	25	c	c	NOUN
bionys-549	131	26	h	h	NOUN
bionys-549	131	27	3	3	NUM
bionys-549	131	28	;	;	PUNCT
bionys-549	131	29	7o	7o	NUM
bionys-549	131	30	-g	-g	PUNCT
bionys-549	131	31	lc	lc	PROPN
bionys-549	131	32	4	4	NUM
bionys-549	131	33	.	.	NOUN
bionys-549	131	34	15	15	NUM
bionys-549	131	35	biologica	biologica	PROPN
bionys-549	131	36	nyssana	nyssana	PROPN
bionys-549	132	1	●	●	PUNCT
bionys-549	132	2	15	15	NUM
bionys-549	132	3	(	(	PUNCT
bionys-549	132	4	2	2	NUM
bionys-549	132	5	)	)	PUNCT
bionys-549	132	6	december	december	PROPN
bionys-549	132	7	2024	2024	NUM
bionys-549	132	8	:	:	PUNCT
bionys-549	132	9	nagarajan	nagarajan	NOUN
bionys-549	132	10	et	et	PROPN
bionys-549	132	11	al	al	PROPN
bionys-549	132	12	.	.	PUNCT
bionys-549	133	1	●	●	PUNCT
bionys-549	133	2	beyond	beyond	ADP
bionys-549	133	3	boundaries	boundary	NOUN
bionys-549	133	4	:	:	PUNCT
bionys-549	133	5	pioneering	pioneer	VERB
bionys-549	133	6	discoveries	discovery	NOUN
bionys-549	133	7	in	in	ADP
bionys-549	133	8	aldose	aldose	PRON
bionys-549	133	9	reductase	reductase	NOUN
bionys-549	133	10	inhibition	inhibition	NOUN
bionys-549	133	11	for	for	ADP
bionys-549	133	12	diabetic	diabetic	ADJ
bionys-549	133	13	neuropathy	neuropathy	ADJ
bionys-549	133	14	table	table	NOUN
bionys-549	133	15	2	2	NUM
bionys-549	133	16	.	.	PUNCT
bionys-549	133	17	quercetin	quercetin	NOUN
bionys-549	133	18	analogues	analogue	NOUN
bionys-549	133	19	and	and	CCONJ
bionys-549	133	20	their	their	PRON
bionys-549	133	21	activity	activity	NOUN
bionys-549	133	22	values	value	NOUN
bionys-549	133	23	compound	compound	VERB
bionys-549	133	24	interactions	interaction	NOUN
bionys-549	133	25	when	when	SCONJ
bionys-549	133	26	docked	dock	VERB
bionys-549	133	27	into	into	ADP
bionys-549	133	28	the	the	DET
bionys-549	133	29	specificity	specificity	NOUN
bionys-549	133	30	pocket	pocket	NOUN
bionys-549	133	31	(	(	PUNCT
bionys-549	133	32	docking	dock	VERB
bionys-549	133	33	score	score	NOUN
bionys-549	133	34	)	)	PUNCT
bionys-549	133	35	interactions	interaction	NOUN
bionys-549	133	36	when	when	SCONJ
bionys-549	133	37	docked	dock	VERB
bionys-549	133	38	into	into	ADP
bionys-549	133	39	the	the	DET
bionys-549	133	40	anionic	anionic	ADJ
bionys-549	133	41	region	region	NOUN
bionys-549	133	42	interactions	interaction	NOUN
bionys-549	133	43	when	when	SCONJ
bionys-549	133	44	docked	dock	VERB
bionys-549	133	45	into	into	ADP
bionys-549	133	46	the	the	DET
bionys-549	133	47	active	active	ADJ
bionys-549	133	48	site	site	NOUN
bionys-549	133	49	selectivity	selectivity	NOUN
bionys-549	133	50	towards	towards	ADP
bionys-549	133	51	bis	bis	ADJ
bionys-549	133	52	-	-	NOUN
bionys-549	133	53	coumarin	coumarin	NOUN
bionys-549	133	54	leu300	leu300	NOUN
bionys-549	133	55	[	[	X
bionys-549	133	56	-11.74	-11.74	X
bionys-549	133	57	]	]	X
bionys-549	133	58	leu300	leu300	NOUN
bionys-549	133	59	[	[	X
bionys-549	133	60	-12.62	-12.62	ADP
bionys-549	133	61	]	]	X
bionys-549	133	62	trp111	trp111	ADP
bionys-549	133	63	[	[	X
bionys-549	133	64	-11.10	-11.10	X
bionys-549	133	65	]	]	X
bionys-549	133	66	intermediate	intermediate	ADJ
bionys-549	133	67	epalrestat	epalrestat	NOUN
bionys-549	133	68	ala299	ala299	PROPN
bionys-549	133	69	,	,	PUNCT
bionys-549	133	70	leu300	leu300	PROPN
bionys-549	134	1	[	[	X
bionys-549	134	2	-12.303	-12.303	X
bionys-549	134	3	]	]	X
bionys-549	134	4	tyr48	tyr48	PROPN
bionys-549	134	5	,	,	PUNCT
bionys-549	134	6	his110	his110	NOUN
bionys-549	134	7	,	,	PUNCT
bionys-549	134	8	trp111	trp111	PROPN
bionys-549	135	1	[	[	X
bionys-549	135	2	-11.07	-11.07	PROPN
bionys-549	135	3	]	]	X
bionys-549	135	4	trp111	trp111	PROPN
bionys-549	135	5	[	[	X
bionys-549	135	6	-11.10	-11.10	X
bionys-549	135	7	]	]	X
bionys-549	135	8	both	both	DET
bionys-549	135	9	regions	region	NOUN
bionys-549	135	10	sulfonic	sulfonic	ADJ
bionys-549	135	11	acid	acid	NOUN
bionys-549	135	12	derivative	derivative	ADJ
bionys-549	135	13	leu301	leu301	PROPN
bionys-549	135	14	,	,	PUNCT
bionys-549	135	15	ser302	ser302	PROPN
bionys-549	135	16	,	,	PUNCT
bionys-549	135	17	trp111	trp111	PROPN
bionys-549	135	18	[	[	X
bionys-549	135	19	-11.04	-11.04	X
bionys-549	135	20	]	]	X
bionys-549	135	21	trp111	trp111	PROPN
bionys-549	135	22	,	,	PUNCT
bionys-549	135	23	tyr48	tyr48	VERB
bionys-549	135	24	[	[	X
bionys-549	135	25	-11.23	-11.23	PROPN
bionys-549	135	26	]	]	X
bionys-549	135	27	ala299	ala299	PROPN
bionys-549	135	28	,	,	PUNCT
bionys-549	135	29	leu300	leu300	PROPN
bionys-549	135	30	,	,	PUNCT
bionys-549	135	31	leu301	leu301	PROPN
bionys-549	135	32	,	,	PUNCT
bionys-549	135	33	trp111	trp111	PROPN
bionys-549	136	1	[	[	X
bionys-549	136	2	-6.684	-6.684	X
bionys-549	136	3	]	]	PUNCT
bionys-549	136	4	both	both	DET
bionys-549	136	5	quercetin	quercetin	NOUN
bionys-549	136	6	leu300	leu300	PROPN
bionys-549	136	7	,	,	PUNCT
bionys-549	136	8	leu301	leu301	PROPN
bionys-549	136	9	[	[	X
bionys-549	136	10	-12.981	-12.981	X
bionys-549	136	11	]	]	X
bionys-549	136	12	leu300	leu300	PROPN
bionys-549	136	13	,	,	PUNCT
bionys-549	136	14	leu301	leu301	PROPN
bionys-549	136	15	[	[	X
bionys-549	136	16	-12.719	-12.719	X
bionys-549	136	17	]	]	X
bionys-549	136	18	ala299	ala299	PROPN
bionys-549	136	19	,	,	PUNCT
bionys-549	136	20	leu301	leu301	PROPN
bionys-549	136	21	,	,	PUNCT
bionys-549	136	22	his110	his110	PROPN
bionys-549	136	23	[	[	X
bionys-549	136	24	-13.293	-13.293	X
bionys-549	136	25	]	]	PUNCT
bionys-549	136	26	specificity	specificity	NOUN
bionys-549	136	27	region	region	NOUN
bionys-549	136	28	rosmarinic	rosmarinic	NOUN
bionys-549	136	29	acid	acid	PROPN
bionys-549	136	30	ser302(2	ser302(2	PROPN
bionys-549	136	31	)	)	PUNCT
bionys-549	136	32	,	,	PUNCT
bionys-549	136	33	leu300	leu300	PROPN
bionys-549	136	34	,	,	PUNCT
bionys-549	136	35	lys221	lys221	PROPN
bionys-549	136	36	[	[	X
bionys-549	136	37	-12.37	-12.37	PROPN
bionys-549	136	38	]	]	X
bionys-549	136	39	val47	val47	ADJ
bionys-549	136	40	,	,	PUNCT
bionys-549	136	41	tyr48	tyr48	NOUN
bionys-549	136	42	,	,	PUNCT
bionys-549	136	43	his110	his110	PROPN
bionys-549	136	44	,	,	PUNCT
bionys-549	136	45	trp111	trp111	PROPN
bionys-549	136	46	,	,	PUNCT
bionys-549	136	47	ala299	ala299	PROPN
bionys-549	136	48	[	[	X
bionys-549	136	49	-14.904	-14.904	X
bionys-549	136	50	]	]	X
bionys-549	136	51	ala299	ala299	PROPN
bionys-549	136	52	,	,	PUNCT
bionys-549	136	53	leu301	leu301	PROPN
bionys-549	136	54	,	,	PUNCT
bionys-549	136	55	nadp	nadp	PROPN
bionys-549	136	56	,	,	PUNCT
bionys-549	136	57	his110	his110	PROPN
bionys-549	136	58	[	[	X
bionys-549	136	59	-17.05	-17.05	X
bionys-549	136	60	]	]	X
bionys-549	136	61	both	both	DET
bionys-549	136	62	regions	region	NOUN
bionys-549	136	63	fidarestat	fidarestat	VERB
bionys-549	136	64	trp111	trp111	ADV
bionys-549	136	65	,	,	PUNCT
bionys-549	136	66	leu300	leu300	PROPN
bionys-549	137	1	[	[	X
bionys-549	137	2	-10.19	-10.19	X
bionys-549	137	3	]	]	X
bionys-549	137	4	trp20	trp20	NOUN
bionys-549	137	5	,	,	PUNCT
bionys-549	137	6	trp111	trp111	PROPN
bionys-549	137	7	,	,	PUNCT
bionys-549	137	8	nadp	nadp	PROPN
bionys-549	138	1	[	[	X
bionys-549	138	2	-10.10	-10.10	X
bionys-549	138	3	]	]	X
bionys-549	138	4	leu300	leu300	ADJ
bionys-549	138	5	,	,	PUNCT
bionys-549	138	6	trp111	trp111	PROPN
bionys-549	138	7	,	,	PUNCT
bionys-549	138	8	his110	his110	NOUN
bionys-549	138	9	,	,	PUNCT
bionys-549	138	10	tyr48	tyr48	VERB
bionys-549	138	11	[	[	X
bionys-549	138	12	-10.45	-10.45	NOUN
bionys-549	138	13	]	]	X
bionys-549	138	14	both	both	DET
bionys-549	138	15	regions	region	NOUN
bionys-549	138	16	idd594	idd594	PROPN
bionys-549	138	17	ala299	ala299	PROPN
bionys-549	138	18	,	,	PUNCT
bionys-549	138	19	leu300	leu300	PROPN
bionys-549	138	20	,	,	PUNCT
bionys-549	138	21	trp111	trp111	PROPN
bionys-549	138	22	[	[	X
bionys-549	138	23	-11.11	-11.11	X
bionys-549	138	24	]	]	X
bionys-549	138	25	trp111	trp111	PROPN
bionys-549	138	26	,	,	PUNCT
bionys-549	138	27	nadp	nadp	PROPN
bionys-549	138	28	,	,	PUNCT
bionys-549	138	29	tyr48	tyr48	VERB
bionys-549	138	30	[	[	X
bionys-549	138	31	-13.13	-13.13	X
bionys-549	138	32	]	]	X
bionys-549	138	33	trp111	trp111	PROPN
bionys-549	138	34	,	,	PUNCT
bionys-549	138	35	his110	his110	NOUN
bionys-549	138	36	,	,	PUNCT
bionys-549	138	37	tyr48	tyr48	VERB
bionys-549	138	38	[	[	NOUN
bionys-549	138	39	-6.457	-6.457	X
bionys-549	138	40	]	]	X
bionys-549	138	41	both	both	DET
bionys-549	138	42	regions	region	NOUN
bionys-549	138	43	methylglyoxal	methylglyoxal	ADJ
bionys-549	138	44	(	(	PUNCT
bionys-549	138	45	meg	meg	NOUN
bionys-549	138	46	)	)	PUNCT
bionys-549	138	47	trp111	trp111	PROPN
bionys-549	138	48	,	,	PUNCT
bionys-549	138	49	his110	his110	PROPN
bionys-549	139	1	[	[	X
bionys-549	139	2	-6.309	-6.309	X
bionys-549	139	3	]	]	X
bionys-549	139	4	trp111	trp111	PROPN
bionys-549	139	5	,	,	PUNCT
bionys-549	139	6	tyr48	tyr48	VERB
bionys-549	139	7	,	,	PUNCT
bionys-549	139	8	his110	his110	PROPN
bionys-549	140	1	[	[	X
bionys-549	140	2	-6.341	-6.341	X
bionys-549	140	3	]	]	X
bionys-549	140	4	trp111	trp111	PROPN
bionys-549	140	5	,	,	PUNCT
bionys-549	140	6	his110	his110	NOUN
bionys-549	140	7	,	,	PUNCT
bionys-549	140	8	tyr48	tyr48	VERB
bionys-549	140	9	[	[	X
bionys-549	140	10	-6.317	-6.317	X
bionys-549	140	11	]	]	X
bionys-549	140	12	both	both	DET
bionys-549	140	13	regions	region	NOUN
bionys-549	140	14	*	*	PUNCT
bionys-549	140	15	glide	glide	NOUN
bionys-549	140	16	scores	score	NOUN
bionys-549	140	17	are	be	AUX
bionys-549	140	18	enclosed	enclose	VERB
bionys-549	140	19	in	in	ADP
bionys-549	140	20	square	square	ADJ
bionys-549	140	21	brackets	bracket	NOUN
bionys-549	140	22	the	the	DET
bionys-549	140	23	volume	volume	NOUN
bionys-549	140	24	that	that	SCONJ
bionys-549	140	25	it	it	PRON
bionys-549	140	26	occupies	occupy	VERB
bionys-549	140	27	represented	represent	VERB
bionys-549	140	28	a	a	DET
bionys-549	140	29	drawback	drawback	NOUN
bionys-549	140	30	.	.	PUNCT
bionys-549	141	1	as	as	ADP
bionys-549	141	2	a	a	DET
bionys-549	141	3	part	part	NOUN
bionys-549	141	4	of	of	ADP
bionys-549	141	5	the	the	DET
bionys-549	141	6	analysis	analysis	NOUN
bionys-549	141	7	for	for	ADP
bionys-549	141	8	this	this	DET
bionys-549	141	9	process	process	NOUN
bionys-549	141	10	,	,	PUNCT
bionys-549	141	11	we	we	PRON
bionys-549	141	12	found	find	VERB
bionys-549	141	13	quercetin	quercetin	NOUN
bionys-549	141	14	selectively	selectively	ADV
bionys-549	141	15	occupying	occupy	VERB
bionys-549	141	16	the	the	DET
bionys-549	141	17	specificity	specificity	NOUN
bionys-549	141	18	pocket	pocket	NOUN
bionys-549	141	19	in	in	ADP
bionys-549	141	20	all	all	DET
bionys-549	141	21	the	the	DET
bionys-549	141	22	three	three	NUM
bionys-549	141	23	cases	case	NOUN
bionys-549	141	24	of	of	ADP
bionys-549	141	25	docking	docking	NOUN
bionys-549	141	26	(	(	PUNCT
bionys-549	141	27	except	except	SCONJ
bionys-549	141	28	for	for	ADP
bionys-549	141	29	one	one	NUM
bionys-549	141	30	case	case	NOUN
bionys-549	141	31	where	where	SCONJ
bionys-549	141	32	it	it	PRON
bionys-549	141	33	made	make	VERB
bionys-549	141	34	interaction	interaction	NOUN
bionys-549	141	35	with	with	ADP
bionys-549	141	36	the	the	DET
bionys-549	141	37	his110	his110	NOUN
bionys-549	141	38	when	when	SCONJ
bionys-549	141	39	docked	dock	VERB
bionys-549	141	40	into	into	ADP
bionys-549	141	41	the	the	DET
bionys-549	141	42	active	active	ADJ
bionys-549	141	43	site	site	NOUN
bionys-549	141	44	as	as	ADP
bionys-549	141	45	a	a	DET
bionys-549	141	46	whole	whole	NOUN
bionys-549	141	47	)	)	PUNCT
bionys-549	141	48	.	.	PUNCT
bionys-549	142	1	quercetin	quercetin	NOUN
bionys-549	142	2	,	,	PUNCT
bionys-549	142	3	a	a	DET
bionys-549	142	4	natural	natural	ADJ
bionys-549	142	5	ligand	ligand	NOUN
bionys-549	142	6	found	find	VERB
bionys-549	142	7	in	in	ADP
bionys-549	142	8	citrus	citrus	NOUN
bionys-549	142	9	fruits	fruit	NOUN
bionys-549	142	10	,	,	PUNCT
bionys-549	142	11	has	have	AUX
bionys-549	142	12	been	be	AUX
bionys-549	142	13	identified	identify	VERB
bionys-549	142	14	as	as	ADP
bionys-549	142	15	a	a	DET
bionys-549	142	16	potent	potent	ADJ
bionys-549	142	17	inhibitor	inhibitor	NOUN
bionys-549	142	18	in	in	ADP
bionys-549	142	19	various	various	ADJ
bionys-549	142	20	in	in	ADP
bionys-549	142	21	vitro	vitro	X
bionys-549	142	22	studies	study	NOUN
bionys-549	142	23	.	.	PUNCT
bionys-549	143	1	however	however	ADV
bionys-549	143	2	,	,	PUNCT
bionys-549	143	3	it	it	PRON
bionys-549	143	4	has	have	AUX
bionys-549	143	5	exhibited	exhibit	VERB
bionys-549	143	6	some	some	DET
bionys-549	143	7	side	side	NOUN
bionys-549	143	8	effects	effect	NOUN
bionys-549	143	9	,	,	PUNCT
bionys-549	143	10	which	which	PRON
bionys-549	143	11	have	have	AUX
bionys-549	143	12	prevented	prevent	VERB
bionys-549	143	13	its	its	PRON
bionys-549	143	14	acceptance	acceptance	NOUN
bionys-549	143	15	as	as	ADP
bionys-549	143	16	a	a	DET
bionys-549	143	17	drug	drug	NOUN
bionys-549	143	18	.	.	PUNCT
bionys-549	144	1	therefore	therefore	ADV
bionys-549	144	2	,	,	PUNCT
bionys-549	144	3	with	with	ADP
bionys-549	144	4	these	these	DET
bionys-549	144	5	observations	observation	NOUN
bionys-549	144	6	we	we	PRON
bionys-549	144	7	took	take	VERB
bionys-549	144	8	over	over	ADP
bionys-549	144	9	quercetin	quercetin	NOUN
bionys-549	144	10	and	and	CCONJ
bionys-549	144	11	proceeded	proceed	VERB
bionys-549	144	12	for	for	ADP
bionys-549	144	13	the	the	DET
bionys-549	144	14	next	next	ADJ
bionys-549	144	15	step	step	NOUN
bionys-549	144	16	of	of	ADP
bionys-549	144	17	developing	develop	VERB
bionys-549	144	18	a	a	DET
bionys-549	144	19	pharmacophore	pharmacophore	NOUN
bionys-549	144	20	model	model	NOUN
bionys-549	144	21	based	base	VERB
bionys-549	144	22	on	on	ADP
bionys-549	144	23	quercetin	quercetin	NOUN
bionys-549	144	24	analogues	analogue	NOUN
bionys-549	144	25	.	.	PUNCT
bionys-549	145	1	pharmacophore	pharmacophore	ADJ
bionys-549	145	2	feature	feature	NOUN
bionys-549	145	3	analysis	analysis	NOUN
bionys-549	145	4	we	we	PRON
bionys-549	145	5	considered	consider	VERB
bionys-549	145	6	the	the	DET
bionys-549	145	7	compounds	compound	NOUN
bionys-549	145	8	that	that	PRON
bionys-549	145	9	docked	dock	VERB
bionys-549	145	10	into	into	ADP
bionys-549	145	11	the	the	DET
bionys-549	145	12	specificity	specificity	NOUN
bionys-549	145	13	region	region	NOUN
bionys-549	145	14	and	and	CCONJ
bionys-549	145	15	studied	study	VERB
bionys-549	145	16	their	their	PRON
bionys-549	145	17	pharmacophore	pharmacophore	NOUN
bionys-549	145	18	features	feature	NOUN
bionys-549	145	19	to	to	PART
bionys-549	145	20	understand	understand	VERB
bionys-549	145	21	the	the	DET
bionys-549	145	22	groups	group	NOUN
bionys-549	145	23	required	require	VERB
bionys-549	145	24	for	for	ADP
bionys-549	145	25	effective	effective	ADJ
bionys-549	145	26	binding	bind	VERB
bionys-549	145	27	into	into	ADP
bionys-549	145	28	that	that	DET
bionys-549	145	29	region	region	NOUN
bionys-549	145	30	.	.	PUNCT
bionys-549	146	1	the	the	DET
bionys-549	146	2	compounds	compound	NOUN
bionys-549	146	3	chosen	choose	VERB
bionys-549	146	4	were	be	AUX
bionys-549	146	5	rosmarinic	rosmarinic	ADJ
bionys-549	146	6	acid	acid	NOUN
bionys-549	146	7	,	,	PUNCT
bionys-549	146	8	sulfonic	sulfonic	ADJ
bionys-549	146	9	acid	acid	NOUN
bionys-549	146	10	derivative	derivative	NOUN
bionys-549	146	11	,	,	PUNCT
bionys-549	146	12	bis	bis	ADJ
bionys-549	146	13	-	-	NOUN
bionys-549	146	14	coumarin	coumarin	NOUN
bionys-549	146	15	,	,	PUNCT
bionys-549	146	16	quercetin	quercetin	NOUN
bionys-549	146	17	,	,	PUNCT
bionys-549	146	18	fidarestat	fidarestat	NOUN
bionys-549	146	19	and	and	CCONJ
bionys-549	146	20	idd594	idd594	PROPN
bionys-549	146	21	(	(	PUNCT
bionys-549	146	22	fig	fig	NOUN
bionys-549	146	23	.	.	PUNCT
bionys-549	146	24	6	6	NUM
bionys-549	146	25	)	)	PUNCT
bionys-549	146	26	.	.	PUNCT
bionys-549	147	1	the	the	DET
bionys-549	147	2	ligands	ligand	NOUN
bionys-549	147	3	were	be	AUX
bionys-549	147	4	prepared	prepare	VERB
bionys-549	147	5	,	,	PUNCT
bionys-549	147	6	and	and	CCONJ
bionys-549	147	7	its	its	PRON
bionys-549	147	8	conformers	conformer	NOUN
bionys-549	147	9	were	be	AUX
bionys-549	147	10	generated	generate	VERB
bionys-549	147	11	as	as	ADP
bionys-549	147	12	a	a	DET
bionys-549	147	13	part	part	NOUN
bionys-549	147	14	of	of	ADP
bionys-549	147	15	the	the	DET
bionys-549	147	16	process	process	NOUN
bionys-549	147	17	.	.	PUNCT
bionys-549	148	1	they	they	PRON
bionys-549	148	2	were	be	AUX
bionys-549	148	3	cleaned	clean	VERB
bionys-549	148	4	later	later	ADV
bionys-549	148	5	to	to	PART
bionys-549	148	6	rule	rule	VERB
bionys-549	148	7	out	out	ADP
bionys-549	148	8	bad	bad	ADJ
bionys-549	148	9	,	,	PUNCT
bionys-549	148	10	duplicated	duplicate	VERB
bionys-549	148	11	structures	structure	NOUN
bionys-549	148	12	.	.	PUNCT
bionys-549	149	1	respective	respective	ADJ
bionys-549	149	2	activity	activity	NOUN
bionys-549	149	3	values	value	NOUN
bionys-549	149	4	were	be	AUX
bionys-549	149	5	specified	specify	VERB
bionys-549	149	6	and	and	CCONJ
bionys-549	149	7	based	base	VERB
bionys-549	149	8	fig	fig	NOUN
bionys-549	149	9	.	.	PUNCT
bionys-549	150	1	7	7	X
bionys-549	150	2	.	.	X
bionys-549	150	3	adr	adr	PROPN
bionys-549	150	4	features	feature	NOUN
bionys-549	150	5	mapped	map	VERB
bionys-549	150	6	over	over	ADP
bionys-549	150	7	quercetin	quercetin	NOUN
bionys-549	150	8	128	128	NUM
bionys-549	150	9	biologica	biologica	PROPN
bionys-549	150	10	nyssana	nyssana	PROPN
bionys-549	150	11	●	●	PUNCT
bionys-549	150	12	15	15	NUM
bionys-549	150	13	(	(	PUNCT
bionys-549	150	14	2	2	NUM
bionys-549	150	15	)	)	PUNCT
bionys-549	150	16	december	december	PROPN
bionys-549	150	17	2024	2024	NUM
bionys-549	150	18	:	:	PUNCT
bionys-549	150	19	nagarajan	nagarajan	NOUN
bionys-549	150	20	et	et	PROPN
bionys-549	150	21	al	al	PROPN
bionys-549	150	22	.	.	PUNCT
bionys-549	151	1	●	●	PUNCT
bionys-549	151	2	beyond	beyond	ADP
bionys-549	151	3	boundaries	boundary	NOUN
bionys-549	151	4	:	:	PUNCT
bionys-549	151	5	pioneering	pioneer	VERB
bionys-549	151	6	discoveries	discovery	NOUN
bionys-549	151	7	in	in	ADP
bionys-549	151	8	aldose	aldose	PRON
bionys-549	151	9	reductase	reductase	NOUN
bionys-549	151	10	inhibition	inhibition	NOUN
bionys-549	151	11	for	for	ADP
bionys-549	151	12	diabetic	diabetic	ADJ
bionys-549	151	13	neuropathy	neuropathy	ADJ
bionys-549	151	14	on	on	ADP
bionys-549	151	15	the	the	DET
bionys-549	151	16	maximum	maximum	ADJ
bionys-549	151	17	hypothesis	hypothesis	NOUN
bionys-549	151	18	generated	generate	VERB
bionys-549	151	19	;	;	PUNCT
bionys-549	151	20	a	a	DET
bionys-549	151	21	3	3	NUM
bionys-549	151	22	-	-	PUNCT
bionys-549	151	23	point	point	NOUN
bionys-549	151	24	pharmacophore	pharmacophore	NOUN
bionys-549	151	25	(	(	PUNCT
bionys-549	151	26	fig	fig	NOUN
bionys-549	151	27	.	.	PUNCT
bionys-549	151	28	7	7	X
bionys-549	151	29	)	)	PUNCT
bionys-549	151	30	was	be	AUX
bionys-549	151	31	obtained	obtain	VERB
bionys-549	151	32	with	with	ADP
bionys-549	151	33	adr	adr	PROPN
bionys-549	151	34	(	(	PUNCT
bionys-549	151	35	acceptor	acceptor	NOUN
bionys-549	151	36	,	,	PUNCT
bionys-549	151	37	donor	donor	NOUN
bionys-549	151	38	and	and	CCONJ
bionys-549	151	39	ring	ring	NOUN
bionys-549	151	40	)	)	PUNCT
bionys-549	151	41	features	feature	NOUN
bionys-549	151	42	.	.	PUNCT
bionys-549	152	1	this	this	PRON
bionys-549	152	2	provided	provide	VERB
bionys-549	152	3	us	we	PRON
bionys-549	152	4	with	with	ADP
bionys-549	152	5	an	an	DET
bionys-549	152	6	understanding	understanding	NOUN
bionys-549	152	7	that	that	PRON
bionys-549	152	8	for	for	SCONJ
bionys-549	152	9	a	a	DET
bionys-549	152	10	molecule	molecule	NOUN
bionys-549	152	11	to	to	PART
bionys-549	152	12	bind	bind	VERB
bionys-549	152	13	into	into	ADP
bionys-549	152	14	the	the	DET
bionys-549	152	15	specificity	specificity	NOUN
bionys-549	152	16	region	region	NOUN
bionys-549	152	17	,	,	PUNCT
bionys-549	152	18	it	it	PRON
bionys-549	152	19	must	must	AUX
bionys-549	152	20	have	have	VERB
bionys-549	152	21	at	at	ADV
bionys-549	152	22	least	least	ADV
bionys-549	152	23	two	two	NUM
bionys-549	152	24	of	of	ADP
bionys-549	152	25	these	these	DET
bionys-549	152	26	three	three	NUM
bionys-549	152	27	or	or	CCONJ
bionys-549	152	28	a	a	DET
bionys-549	152	29	combination	combination	NOUN
bionys-549	152	30	of	of	ADP
bionys-549	152	31	such	such	ADJ
bionys-549	152	32	features	feature	NOUN
bionys-549	152	33	.	.	PUNCT
bionys-549	153	1	since	since	SCONJ
bionys-549	153	2	our	our	PRON
bionys-549	153	3	specificity	specificity	NOUN
bionys-549	153	4	comprises	comprise	VERB
bionys-549	153	5	the	the	DET
bionys-549	153	6	residues	residue	NOUN
bionys-549	153	7	ala299	ala299	PROPN
bionys-549	153	8	and	and	CCONJ
bionys-549	153	9	leu300	leu300	PROPN
bionys-549	153	10	-	-	PUNCT
bionys-549	153	11	301	301	NUM
bionys-549	153	12	,	,	PUNCT
bionys-549	153	13	which	which	PRON
bionys-549	153	14	possess	possess	VERB
bionys-549	153	15	hydrogen	hydrogen	NOUN
bionys-549	153	16	bond	bond	NOUN
bionys-549	153	17	donor	donor	NOUN
bionys-549	153	18	/	/	SYM
bionys-549	153	19	acceptor	acceptor	NOUN
bionys-549	153	20	functionalities	functionality	NOUN
bionys-549	153	21	,	,	PUNCT
bionys-549	153	22	it	it	PRON
bionys-549	153	23	facilitates	facilitate	VERB
bionys-549	153	24	interactions	interaction	NOUN
bionys-549	153	25	that	that	PRON
bionys-549	153	26	form	form	VERB
bionys-549	153	27	hydrogen	hydrogen	NOUN
bionys-549	153	28	bonds	bond	NOUN
bionys-549	153	29	with	with	ADP
bionys-549	153	30	incoming	incoming	ADJ
bionys-549	153	31	ligand	ligand	NOUN
bionys-549	153	32	molecules	molecule	NOUN
bionys-549	153	33	.	.	PUNCT
bionys-549	154	1	provided	provide	VERB
bionys-549	154	2	that	that	SCONJ
bionys-549	154	3	the	the	DET
bionys-549	154	4	ligand	ligand	NOUN
bionys-549	154	5	is	be	AUX
bionys-549	154	6	appropriately	appropriately	ADV
bionys-549	154	7	sized	sized	ADJ
bionys-549	154	8	,	,	PUNCT
bionys-549	154	9	it	it	PRON
bionys-549	154	10	will	will	AUX
bionys-549	154	11	engage	engage	VERB
bionys-549	154	12	exclusively	exclusively	ADV
bionys-549	154	13	with	with	ADP
bionys-549	154	14	the	the	DET
bionys-549	154	15	specificity	specificity	NOUN
bionys-549	154	16	region	region	NOUN
bionys-549	154	17	and	and	CCONJ
bionys-549	154	18	will	will	AUX
bionys-549	154	19	not	not	PART
bionys-549	154	20	intrude	intrude	VERB
bionys-549	154	21	into	into	ADP
bionys-549	154	22	the	the	DET
bionys-549	154	23	anionic	anionic	ADJ
bionys-549	154	24	region	region	NOUN
bionys-549	154	25	of	of	ADP
bionys-549	154	26	the	the	DET
bionys-549	154	27	active	active	ADJ
bionys-549	154	28	site	site	NOUN
bionys-549	154	29	.	.	PUNCT
bionys-549	155	1	although	although	SCONJ
bionys-549	155	2	sulfonic	sulfonic	ADJ
bionys-549	155	3	acid	acid	NOUN
bionys-549	155	4	derivative	derivative	NOUN
bionys-549	155	5	showed	show	VERB
bionys-549	155	6	good	good	ADJ
bionys-549	155	7	fitness	fitness	NOUN
bionys-549	155	8	(	(	PUNCT
bionys-549	155	9	3.000	3.000	NUM
bionys-549	155	10	)	)	PUNCT
bionys-549	155	11	and	and	CCONJ
bionys-549	155	12	a	a	DET
bionys-549	155	13	better	well	ADJ
bionys-549	155	14	alignment	alignment	NOUN
bionys-549	155	15	score	score	NOUN
bionys-549	155	16	(	(	PUNCT
bionys-549	155	17	0.000	0.000	NUM
bionys-549	155	18	)	)	PUNCT
bionys-549	155	19	than	than	ADP
bionys-549	155	20	quercetin	quercetin	NOUN
bionys-549	155	21	,	,	PUNCT
bionys-549	155	22	it	it	PRON
bionys-549	155	23	does	do	AUX
bionys-549	155	24	not	not	PART
bionys-549	155	25	satisfy	satisfy	VERB
bionys-549	155	26	the	the	DET
bionys-549	155	27	necessary	necessary	ADJ
bionys-549	155	28	criteria	criterion	NOUN
bionys-549	155	29	and	and	CCONJ
bionys-549	155	30	was	be	AUX
bionys-549	155	31	found	find	VERB
bionys-549	155	32	extending	extend	VERB
bionys-549	155	33	into	into	ADP
bionys-549	155	34	the	the	DET
bionys-549	155	35	anionic	anionic	ADJ
bionys-549	155	36	region	region	NOUN
bionys-549	155	37	during	during	ADP
bionys-549	155	38	the	the	DET
bionys-549	155	39	initial	initial	ADJ
bionys-549	155	40	docking	docking	NOUN
bionys-549	155	41	analysis	analysis	NOUN
bionys-549	155	42	.	.	PUNCT
bionys-549	156	1	also	also	ADV
bionys-549	156	2	,	,	PUNCT
bionys-549	156	3	quercetin	quercetin	NOUN
bionys-549	156	4	comparatively	comparatively	ADV
bionys-549	156	5	had	have	VERB
bionys-549	156	6	better	well	ADJ
bionys-549	156	7	fitness	fitness	NOUN
bionys-549	156	8	(	(	PUNCT
bionys-549	156	9	2.328	2.328	NUM
bionys-549	156	10	)	)	PUNCT
bionys-549	156	11	and	and	CCONJ
bionys-549	156	12	a	a	DET
bionys-549	156	13	good	good	ADJ
bionys-549	156	14	alignment	alignment	NOUN
bionys-549	156	15	score	score	NOUN
bionys-549	156	16	(	(	PUNCT
bionys-549	156	17	0.033	0.033	NUM
bionys-549	156	18	)	)	PUNCT
bionys-549	156	19	.	.	PUNCT
bionys-549	157	1	the	the	DET
bionys-549	157	2	size	size	NOUN
bionys-549	157	3	and	and	CCONJ
bionys-549	157	4	the	the	DET
bionys-549	157	5	volume	volume	NOUN
bionys-549	157	6	it	it	PRON
bionys-549	157	7	occupies	occupy	VERB
bionys-549	157	8	places	place	NOUN
bionys-549	157	9	quercetin	quercetin	NOUN
bionys-549	157	10	ahead	ahead	ADV
bionys-549	157	11	of	of	ADP
bionys-549	157	12	sulfonic	sulfonic	ADJ
bionys-549	157	13	acid	acid	NOUN
bionys-549	157	14	derivative	derivative	NOUN
bionys-549	157	15	to	to	PART
bionys-549	157	16	be	be	AUX
bionys-549	157	17	taken	take	VERB
bionys-549	157	18	for	for	ADP
bionys-549	157	19	further	further	ADJ
bionys-549	157	20	studies	study	NOUN
bionys-549	157	21	.	.	PUNCT
bionys-549	158	1	the	the	DET
bionys-549	158	2	specificity	specificity	NOUN
bionys-549	158	3	pocket	pocket	NOUN
bionys-549	158	4	has	have	VERB
bionys-549	158	5	the	the	DET
bionys-549	158	6	property	property	NOUN
bionys-549	158	7	of	of	ADP
bionys-549	158	8	adapting	adapt	VERB
bionys-549	158	9	different	different	ADJ
bionys-549	158	10	inhibitors	inhibitor	NOUN
bionys-549	158	11	since	since	SCONJ
bionys-549	158	12	the	the	DET
bionys-549	158	13	residues	residue	NOUN
bionys-549	158	14	297	297	NUM
bionys-549	158	15	-	-	SYM
bionys-549	158	16	300	300	NUM
bionys-549	158	17	show	show	NOUN
bionys-549	158	18	adaptations	adaptation	NOUN
bionys-549	158	19	with	with	ADP
bionys-549	158	20	respect	respect	NOUN
bionys-549	158	21	to	to	ADP
bionys-549	158	22	the	the	DET
bionys-549	158	23	inhibitor	inhibitor	NOUN
bionys-549	158	24	binding	bind	VERB
bionys-549	158	25	to	to	ADP
bionys-549	158	26	it	it	PRON
bionys-549	158	27	.	.	PUNCT
bionys-549	159	1	as	as	ADP
bionys-549	159	2	a	a	DET
bionys-549	159	3	smaller	small	ADJ
bionys-549	159	4	molecule	molecule	NOUN
bionys-549	159	5	than	than	ADP
bionys-549	159	6	the	the	DET
bionys-549	159	7	sulfonic	sulfonic	ADJ
bionys-549	159	8	acid	acid	NOUN
bionys-549	159	9	derivative	derivative	NOUN
bionys-549	159	10	,	,	PUNCT
bionys-549	159	11	quercetin	quercetin	NOUN
bionys-549	159	12	can	can	AUX
bionys-549	159	13	create	create	VERB
bionys-549	159	14	space	space	NOUN
bionys-549	159	15	for	for	ADP
bionys-549	159	16	toxic	toxic	ADJ
bionys-549	159	17	aldehydes	aldehyde	NOUN
bionys-549	159	18	to	to	PART
bionys-549	159	19	enter	enter	VERB
bionys-549	159	20	upon	upon	SCONJ
bionys-549	159	21	binding	bind	VERB
bionys-549	159	22	.	.	PUNCT
bionys-549	160	1	in	in	ADP
bionys-549	160	2	contrast	contrast	NOUN
bionys-549	160	3	,	,	PUNCT
bionys-549	160	4	the	the	DET
bionys-549	160	5	sulfonic	sulfonic	ADJ
bionys-549	160	6	acid	acid	NOUN
bionys-549	160	7	derivative	derivative	NOUN
bionys-549	160	8	fits	fit	VERB
bionys-549	160	9	perfectly	perfectly	ADV
bionys-549	160	10	at	at	ADP
bionys-549	160	11	the	the	DET
bionys-549	160	12	entry	entry	NOUN
bionys-549	160	13	of	of	ADP
bionys-549	160	14	the	the	DET
bionys-549	160	15	active	active	ADJ
bionys-549	160	16	site	site	NOUN
bionys-549	160	17	,	,	PUNCT
bionys-549	160	18	preventing	prevent	VERB
bionys-549	160	19	additional	additional	ADJ
bionys-549	160	20	compounds	compound	NOUN
bionys-549	160	21	from	from	ADP
bionys-549	160	22	accessing	access	VERB
bionys-549	160	23	this	this	DET
bionys-549	160	24	space	space	NOUN
bionys-549	160	25	.	.	PUNCT
bionys-549	161	1	pharmacophore	pharmacophore	PROPN
bionys-549	161	2	model	model	PROPN
bionys-549	161	3	development	development	PROPN
bionys-549	161	4	quercetin	quercetin	NOUN
bionys-549	161	5	analogues	analogue	NOUN
bionys-549	161	6	were	be	AUX
bionys-549	161	7	designed	design	VERB
bionys-549	161	8	as	as	SCONJ
bionys-549	161	9	described	describe	VERB
bionys-549	161	10	earlier	early	ADV
bionys-549	161	11	in	in	ADP
bionys-549	161	12	tab	tab	NOUN
bionys-549	161	13	.	.	PUNCT
bionys-549	162	1	1	1	NUM
bionys-549	162	2	using	use	VERB
bionys-549	162	3	symyx	symyx	NOUN
bionys-549	162	4	draw	draw	VERB
bionys-549	162	5	v4.0	v4.0	NOUN
bionys-549	162	6	.	.	PUNCT
bionys-549	163	1	these	these	DET
bionys-549	163	2	ligands	ligand	NOUN
bionys-549	163	3	were	be	AUX
bionys-549	163	4	generated	generate	VERB
bionys-549	163	5	with	with	ADP
bionys-549	163	6	ligprep	ligprep	NOUN
bionys-549	163	7	of	of	ADP
bionys-549	163	8	the	the	DET
bionys-549	163	9	maestro	maestro	PROPN
bionys-549	163	10	v9.1	v9.1	PROPN
bionys-549	163	11	gui	gui	NOUN
bionys-549	163	12	interface	interface	NOUN
bionys-549	163	13	.	.	PUNCT
bionys-549	164	1	conformers	conformer	NOUN
bionys-549	164	2	were	be	AUX
bionys-549	164	3	generated	generate	VERB
bionys-549	164	4	and	and	CCONJ
bionys-549	164	5	their	their	PRON
bionys-549	164	6	geometries	geometry	NOUN
bionys-549	164	7	were	be	AUX
bionys-549	164	8	cleaned	clean	VERB
bionys-549	164	9	accordingly	accordingly	ADV
bionys-549	164	10	to	to	PART
bionys-549	164	11	rule	rule	VERB
bionys-549	164	12	out	out	ADP
bionys-549	164	13	bad	bad	ADJ
bionys-549	164	14	as	as	ADV
bionys-549	164	15	well	well	ADV
bionys-549	164	16	as	as	ADP
bionys-549	164	17	duplicate	duplicate	ADJ
bionys-549	164	18	structures	structure	NOUN
bionys-549	164	19	.	.	PUNCT
bionys-549	165	1	activity	activity	NOUN
bionys-549	165	2	values	value	NOUN
bionys-549	165	3	(	(	PUNCT
bionys-549	165	4	pic50	pic50	NOUN
bionys-549	165	5	)	)	PUNCT
bionys-549	165	6	were	be	AUX
bionys-549	165	7	specified	specify	VERB
bionys-549	165	8	to	to	PART
bionys-549	165	9	separate	separate	VERB
bionys-549	165	10	out	out	ADP
bionys-549	165	11	the	the	DET
bionys-549	165	12	active	active	ADJ
bionys-549	165	13	from	from	ADP
bionys-549	165	14	the	the	DET
bionys-549	165	15	inactive	inactive	ADJ
bionys-549	165	16	molecules	molecule	NOUN
bionys-549	165	17	.	.	PUNCT
bionys-549	166	1	with	with	ADP
bionys-549	166	2	quercetin	quercetin	NOUN
bionys-549	166	3	in	in	ADP
bionys-549	166	4	mind	mind	NOUN
bionys-549	166	5	,	,	PUNCT
bionys-549	166	6	a	a	DET
bionys-549	166	7	6	6	NUM
bionys-549	166	8	-	-	PUNCT
bionys-549	166	9	point	point	NOUN
bionys-549	166	10	pharmacophore	pharmacophore	NOUN
bionys-549	166	11	model	model	NOUN
bionys-549	166	12	was	be	AUX
bionys-549	166	13	developed	develop	VERB
bionys-549	166	14	,	,	PUNCT
bionys-549	166	15	achieving	achieve	VERB
bionys-549	166	16	the	the	DET
bionys-549	166	17	highest	high	ADJ
bionys-549	166	18	score	score	NOUN
bionys-549	166	19	for	for	ADP
bionys-549	166	20	this	this	DET
bionys-549	166	21	hypothesis	hypothesis	NOUN
bionys-549	166	22	.	.	PUNCT
bionys-549	167	1	the	the	DET
bionys-549	167	2	model	model	NOUN
bionys-549	167	3	(	(	PUNCT
bionys-549	167	4	fig	fig	NOUN
bionys-549	167	5	.	.	PUNCT
bionys-549	167	6	8)	8)	NUM
bionys-549	167	7	had	have	VERB
bionys-549	167	8	the	the	DET
bionys-549	167	9	features	feature	NOUN
bionys-549	167	10	aaarrr	aaarrr	NOUN
bionys-549	167	11	(	(	PUNCT
bionys-549	167	12	3	3	NUM
bionys-549	167	13	h	h	NOUN
bionys-549	167	14	-	-	PUNCT
bionys-549	167	15	bond	bond	NOUN
bionys-549	167	16	acceptors	acceptor	NOUN
bionys-549	167	17	and	and	CCONJ
bionys-549	167	18	3	3	NUM
bionys-549	167	19	aromatic	aromatic	ADJ
bionys-549	167	20	characteristics	characteristic	NOUN
bionys-549	167	21	)	)	PUNCT
bionys-549	167	22	.	.	PUNCT
bionys-549	168	1	the	the	DET
bionys-549	168	2	three	three	NUM
bionys-549	168	3	ring	ring	NOUN
bionys-549	168	4	features	feature	NOUN
bionys-549	168	5	aligned	align	VERB
bionys-549	168	6	with	with	ADP
bionys-549	168	7	the	the	DET
bionys-549	168	8	core	core	NOUN
bionys-549	168	9	structure	structure	NOUN
bionys-549	168	10	of	of	ADP
bionys-549	168	11	a	a	DET
bionys-549	168	12	flavonoid	flavonoid	NOUN
bionys-549	168	13	.	.	PUNCT
bionys-549	169	1	in	in	ADP
bionys-549	169	2	our	our	PRON
bionys-549	169	3	case	case	NOUN
bionys-549	169	4	,	,	PUNCT
bionys-549	169	5	quercetin	quercetin	NOUN
bionys-549	169	6	,	,	PUNCT
bionys-549	169	7	the	the	DET
bionys-549	169	8	obtained	obtain	VERB
bionys-549	169	9	model	model	NOUN
bionys-549	169	10	provides	provide	VERB
bionys-549	169	11	better	well	ADJ
bionys-549	169	12	chance	chance	NOUN
bionys-549	169	13	for	for	ADP
bionys-549	169	14	searching	search	VERB
bionys-549	169	15	an	an	DET
bionys-549	169	16	optimum	optimum	ADJ
bionys-549	169	17	compound	compound	NOUN
bionys-549	169	18	with	with	ADP
bionys-549	169	19	the	the	DET
bionys-549	169	20	6	6	NUM
bionys-549	169	21	features	feature	NOUN
bionys-549	169	22	since	since	SCONJ
bionys-549	169	23	it	it	PRON
bionys-549	169	24	could	could	AUX
bionys-549	169	25	result	result	VERB
bionys-549	169	26	in	in	ADP
bionys-549	169	27	finding	find	VERB
bionys-549	169	28	a	a	DET
bionys-549	169	29	molecule	molecule	NOUN
bionys-549	169	30	which	which	PRON
bionys-549	169	31	will	will	AUX
bionys-549	169	32	have	have	VERB
bionys-549	169	33	a	a	DET
bionys-549	169	34	smaller	small	ADJ
bionys-549	169	35	size	size	NOUN
bionys-549	169	36	and	and	CCONJ
bionys-549	169	37	could	could	AUX
bionys-549	169	38	make	make	VERB
bionys-549	169	39	hydrogen	hydrogen	NOUN
bionys-549	169	40	bonds	bond	NOUN
bionys-549	169	41	with	with	ADP
bionys-549	169	42	the	the	DET
bionys-549	169	43	specificity	specificity	NOUN
bionys-549	169	44	pocket	pocket	NOUN
bionys-549	169	45	easily	easily	ADV
bionys-549	169	46	.	.	PUNCT
bionys-549	170	1	this	this	PRON
bionys-549	170	2	will	will	AUX
bionys-549	170	3	help	help	VERB
bionys-549	170	4	us	we	PRON
bionys-549	170	5	finding	find	VERB
bionys-549	170	6	a	a	DET
bionys-549	170	7	molecule	molecule	NOUN
bionys-549	170	8	with	with	ADP
bionys-549	170	9	a	a	DET
bionys-549	170	10	similar	similar	ADJ
bionys-549	170	11	core	core	NOUN
bionys-549	170	12	structure	structure	NOUN
bionys-549	170	13	(	(	PUNCT
bionys-549	170	14	3	3	NUM
bionys-549	170	15	ring	ring	NOUN
bionys-549	170	16	structures	structure	NOUN
bionys-549	170	17	)	)	PUNCT
bionys-549	170	18	which	which	PRON
bionys-549	170	19	is	be	AUX
bionys-549	170	20	important	important	ADJ
bionys-549	170	21	for	for	ADP
bionys-549	170	22	our	our	PRON
bionys-549	170	23	study	study	NOUN
bionys-549	170	24	such	such	ADJ
bionys-549	170	25	that	that	SCONJ
bionys-549	170	26	the	the	DET
bionys-549	170	27	functional	functional	ADJ
bionys-549	170	28	groups	group	NOUN
bionys-549	170	29	would	would	AUX
bionys-549	170	30	bind	bind	VERB
bionys-549	170	31	accordingly	accordingly	ADV
bionys-549	170	32	to	to	ADP
bionys-549	170	33	the	the	DET
bionys-549	170	34	residues	residue	NOUN
bionys-549	170	35	in	in	ADP
bionys-549	170	36	the	the	DET
bionys-549	170	37	specificity	specificity	NOUN
bionys-549	170	38	region	region	NOUN
bionys-549	170	39	rather	rather	ADV
bionys-549	170	40	than	than	ADP
bionys-549	170	41	entering	enter	VERB
bionys-549	170	42	the	the	DET
bionys-549	170	43	anionic	anionic	ADJ
bionys-549	170	44	region	region	NOUN
bionys-549	170	45	.	.	PUNCT
bionys-549	171	1	virtual	virtual	ADJ
bionys-549	171	2	screening	screen	VERB
bionys-549	171	3	the	the	DET
bionys-549	171	4	6	6	NUM
bionys-549	171	5	–	–	PUNCT
bionys-549	171	6	point	point	NOUN
bionys-549	171	7	pharmacophore	pharmacophore	NOUN
bionys-549	171	8	(	(	PUNCT
bionys-549	171	9	aaarrr	aaarrr	PROPN
bionys-549	171	10	)	)	PUNCT
bionys-549	171	11	was	be	AUX
bionys-549	171	12	used	use	VERB
bionys-549	171	13	as	as	ADP
bionys-549	171	14	the	the	DET
bionys-549	171	15	basis	basis	NOUN
bionys-549	171	16	for	for	ADP
bionys-549	171	17	search	search	NOUN
bionys-549	171	18	from	from	ADP
bionys-549	171	19	a	a	DET
bionys-549	171	20	library	library	NOUN
bionys-549	171	21	of	of	ADP
bionys-549	171	22	natural	natural	ADJ
bionys-549	171	23	compounds	compound	NOUN
bionys-549	171	24	obtained	obtain	VERB
bionys-549	171	25	from	from	ADP
bionys-549	171	26	ibs	ib	NOUN
bionys-549	171	27	database	database	NOUN
bionys-549	171	28	(	(	PUNCT
bionys-549	171	29	interbioscreen	interbioscreen	NOUN
bionys-549	171	30	)	)	PUNCT
bionys-549	171	31	.	.	PUNCT
bionys-549	172	1	a	a	DET
bionys-549	172	2	total	total	NOUN
bionys-549	172	3	of	of	ADP
bionys-549	172	4	82,000	82,000	NUM
bionys-549	172	5	compounds	compound	NOUN
bionys-549	172	6	were	be	AUX
bionys-549	172	7	taken	take	VERB
bionys-549	172	8	from	from	ADP
bionys-549	172	9	the	the	DET
bionys-549	172	10	database	database	NOUN
bionys-549	172	11	and	and	CCONJ
bionys-549	172	12	a	a	DET
bionys-549	172	13	pharmacophore	pharmacophore	NOUN
bionys-549	172	14	-	-	PUNCT
bionys-549	172	15	based	base	VERB
bionys-549	172	16	search	search	NOUN
bionys-549	172	17	was	be	AUX
bionys-549	172	18	carried	carry	VERB
bionys-549	172	19	out	out	ADP
bionys-549	172	20	.	.	PUNCT
bionys-549	173	1	2394	2394	NUM
bionys-549	173	2	hits	hit	NOUN
bionys-549	173	3	were	be	AUX
bionys-549	173	4	obtained	obtain	VERB
bionys-549	173	5	as	as	ADP
bionys-549	173	6	a	a	DET
bionys-549	173	7	result	result	NOUN
bionys-549	173	8	of	of	ADP
bionys-549	173	9	the	the	DET
bionys-549	173	10	initial	initial	ADJ
bionys-549	173	11	search	search	NOUN
bionys-549	173	12	.	.	PUNCT
bionys-549	174	1	these	these	DET
bionys-549	174	2	hits	hit	NOUN
bionys-549	174	3	were	be	AUX
bionys-549	174	4	stored	store	VERB
bionys-549	174	5	as	as	ADP
bionys-549	174	6	a	a	DET
bionys-549	174	7	separate	separate	ADJ
bionys-549	174	8	entry	entry	NOUN
bionys-549	174	9	and	and	CCONJ
bionys-549	174	10	prepared	prepare	VERB
bionys-549	174	11	using	use	VERB
bionys-549	174	12	ligprep	ligprep	ADJ
bionys-549	174	13	module	module	NOUN
bionys-549	174	14	of	of	ADP
bionys-549	174	15	the	the	DET
bionys-549	174	16	gui	gui	NOUN
bionys-549	174	17	maestro	maestro	PROPN
bionys-549	174	18	v9.1	v9.1	PROPN
bionys-549	174	19	.	.	PUNCT
bionys-549	175	1	ligprep	ligprep	PROPN
bionys-549	175	2	helps	help	VERB
bionys-549	175	3	in	in	ADP
bionys-549	175	4	generating	generate	VERB
bionys-549	175	5	conformers	conformer	NOUN
bionys-549	175	6	and	and	CCONJ
bionys-549	175	7	unique	unique	ADJ
bionys-549	175	8	geometries	geometry	NOUN
bionys-549	175	9	.	.	PUNCT
bionys-549	176	1	after	after	ADP
bionys-549	176	2	preparation	preparation	NOUN
bionys-549	176	3	we	we	PRON
bionys-549	176	4	had	have	VERB
bionys-549	176	5	5745	5745	NUM
bionys-549	176	6	entries	entry	NOUN
bionys-549	176	7	in	in	ADP
bionys-549	176	8	hand	hand	NOUN
bionys-549	176	9	.	.	PUNCT
bionys-549	177	1	we	we	PRON
bionys-549	177	2	proceeded	proceed	VERB
bionys-549	177	3	with	with	ADP
bionys-549	177	4	a	a	DET
bionys-549	177	5	stepwise	stepwise	ADJ
bionys-549	177	6	docking	docking	NOUN
bionys-549	177	7	-	-	PUNCT
bionys-549	177	8	based	base	VERB
bionys-549	177	9	screening	screening	NOUN
bionys-549	177	10	process	process	NOUN
bionys-549	177	11	to	to	PART
bionys-549	177	12	screen	screen	VERB
bionys-549	177	13	out	out	ADP
bionys-549	177	14	compounds	compound	NOUN
bionys-549	177	15	and	and	CCONJ
bionys-549	177	16	retain	retain	VERB
bionys-549	177	17	the	the	DET
bionys-549	177	18	best	good	ADJ
bionys-549	177	19	ones	one	NOUN
bionys-549	177	20	.	.	PUNCT
bionys-549	178	1	the	the	DET
bionys-549	178	2	three	three	NUM
bionys-549	178	3	stages	stage	NOUN
bionys-549	178	4	included	include	VERB
bionys-549	178	5	htvs	htvs	NOUN
bionys-549	178	6	docking	docking	NOUN
bionys-549	178	7	,	,	PUNCT
bionys-549	178	8	sp	sp	ADP
bionys-549	178	9	docking	docking	NOUN
bionys-549	178	10	and	and	CCONJ
bionys-549	178	11	xp	xp	ADV
bionys-549	178	12	docking	docking	NOUN
bionys-549	178	13	.	.	PUNCT
bionys-549	179	1	in	in	ADP
bionys-549	179	2	high	high	ADJ
bionys-549	179	3	throughput	throughput	NOUN
bionys-549	179	4	virtual	virtual	ADJ
bionys-549	179	5	screening	screening	NOUN
bionys-549	179	6	docking	docking	NOUN
bionys-549	179	7	,	,	PUNCT
bionys-549	179	8	the	the	DET
bionys-549	179	9	criteria	criterion	NOUN
bionys-549	179	10	were	be	AUX
bionys-549	179	11	set	set	VERB
bionys-549	179	12	to	to	PART
bionys-549	179	13	retain	retain	VERB
bionys-549	179	14	only	only	ADV
bionys-549	179	15	5	5	NUM
bionys-549	179	16	%	%	NOUN
bionys-549	179	17	of	of	ADP
bionys-549	179	18	the	the	DET
bionys-549	179	19	best	good	ADJ
bionys-549	179	20	posed	pose	VERB
bionys-549	179	21	molecule	molecule	NOUN
bionys-549	179	22	conformations	conformation	NOUN
bionys-549	179	23	.	.	PUNCT
bionys-549	180	1	this	this	PRON
bionys-549	180	2	brought	bring	VERB
bionys-549	180	3	down	down	ADP
bionys-549	180	4	the	the	DET
bionys-549	180	5	number	number	NOUN
bionys-549	180	6	of	of	ADP
bionys-549	180	7	hits	hit	NOUN
bionys-549	180	8	to	to	ADP
bionys-549	180	9	287	287	NUM
bionys-549	180	10	.	.	PUNCT
bionys-549	181	1	in	in	ADP
bionys-549	181	2	standard	standard	ADJ
bionys-549	181	3	precision	precision	NOUN
bionys-549	181	4	docking	docking	NOUN
bionys-549	181	5	,	,	PUNCT
bionys-549	181	6	the	the	DET
bionys-549	181	7	criteria	criterion	NOUN
bionys-549	181	8	were	be	AUX
bionys-549	181	9	set	set	VERB
bionys-549	181	10	to	to	PART
bionys-549	181	11	retain	retain	VERB
bionys-549	181	12	10	10	NUM
bionys-549	181	13	%	%	NOUN
bionys-549	181	14	of	of	ADP
bionys-549	181	15	the	the	DET
bionys-549	181	16	best	good	ADJ
bionys-549	181	17	posed	pose	VERB
bionys-549	181	18	molecule	molecule	NOUN
bionys-549	181	19	conformations	conformation	NOUN
bionys-549	181	20	.	.	PUNCT
bionys-549	182	1	thus	thus	ADV
bionys-549	182	2	,	,	PUNCT
bionys-549	182	3	we	we	PRON
bionys-549	182	4	ended	end	VERB
bionys-549	182	5	up	up	ADP
bionys-549	182	6	with	with	ADP
bionys-549	182	7	28	28	NUM
bionys-549	182	8	compounds	compound	NOUN
bionys-549	182	9	for	for	ADP
bionys-549	182	10	the	the	DET
bionys-549	182	11	final	final	ADJ
bionys-549	182	12	screening	screening	NOUN
bionys-549	182	13	procedure	procedure	NOUN
bionys-549	182	14	.	.	PUNCT
bionys-549	183	1	using	use	VERB
bionys-549	183	2	extra	extra	ADJ
bionys-549	183	3	precision	precision	NOUN
bionys-549	183	4	docking	docking	NOUN
bionys-549	183	5	,	,	PUNCT
bionys-549	183	6	we	we	PRON
bionys-549	183	7	initially	initially	ADV
bionys-549	183	8	selected	select	VERB
bionys-549	183	9	the	the	DET
bionys-549	183	10	top	top	ADJ
bionys-549	183	11	14	14	NUM
bionys-549	183	12	hits	hit	NOUN
bionys-549	183	13	from	from	ADP
bionys-549	183	14	the	the	DET
bionys-549	183	15	sp	sp	ADP
bionys-549	183	16	docking	docking	NOUN
bionys-549	183	17	based	base	VERB
bionys-549	183	18	on	on	ADP
bionys-549	183	19	their	their	PRON
bionys-549	183	20	scores	score	NOUN
bionys-549	183	21	and	and	CCONJ
bionys-549	183	22	retained	retain	VERB
bionys-549	183	23	the	the	DET
bionys-549	183	24	best	good	ADJ
bionys-549	183	25	pose	pose	NOUN
bionys-549	183	26	from	from	ADP
bionys-549	183	27	this	this	DET
bionys-549	183	28	step	step	NOUN
bionys-549	183	29	.	.	PUNCT
bionys-549	184	1	consequently	consequently	ADV
bionys-549	184	2	,	,	PUNCT
bionys-549	184	3	we	we	PRON
bionys-549	184	4	identified	identify	VERB
bionys-549	184	5	a	a	DET
bionys-549	184	6	specific	specific	ADJ
bionys-549	184	7	hit	hit	NOUN
bionys-549	184	8	that	that	PRON
bionys-549	184	9	docked	dock	VERB
bionys-549	184	10	as	as	SCONJ
bionys-549	184	11	anticipated	anticipate	VERB
bionys-549	184	12	in	in	ADP
bionys-549	184	13	the	the	DET
bionys-549	184	14	entry	entry	NOUN
bionys-549	184	15	region	region	NOUN
bionys-549	184	16	of	of	ADP
bionys-549	184	17	the	the	DET
bionys-549	184	18	specificity	specificity	NOUN
bionys-549	184	19	pocket	pocket	NOUN
bionys-549	184	20	.	.	PUNCT
bionys-549	185	1	the	the	DET
bionys-549	185	2	final	final	ADJ
bionys-549	185	3	hit	hit	NOUN
bionys-549	185	4	,	,	PUNCT
bionys-549	185	5	mol_7921	mol_7921	NUM
bionys-549	185	6	,	,	PUNCT
bionys-549	185	7	exhibited	exhibit	VERB
bionys-549	185	8	a	a	DET
bionys-549	185	9	core	core	NOUN
bionys-549	185	10	structure	structure	NOUN
bionys-549	185	11	similar	similar	ADJ
bionys-549	185	12	to	to	ADP
bionys-549	185	13	that	that	PRON
bionys-549	185	14	of	of	ADP
bionys-549	185	15	quercetin	quercetin	NOUN
bionys-549	185	16	(	(	PUNCT
bionys-549	185	17	fig	fig	NOUN
bionys-549	185	18	.	.	PUNCT
bionys-549	186	1	9	9	NUM
bionys-549	186	2	)	)	PUNCT
bionys-549	186	3	.	.	PUNCT
bionys-549	187	1	it	it	PRON
bionys-549	187	2	occupied	occupy	VERB
bionys-549	187	3	the	the	DET
bionys-549	187	4	specificity	specificity	NOUN
bionys-549	187	5	pocket	pocket	NOUN
bionys-549	187	6	making	make	VERB
bionys-549	187	7	strong	strong	ADJ
bionys-549	187	8	hydrogen	hydrogen	NOUN
bionys-549	187	9	bond	bond	NOUN
bionys-549	187	10	interaction	interaction	NOUN
bionys-549	187	11	with	with	ADP
bionys-549	187	12	residues	residue	NOUN
bionys-549	187	13	val297	val297	PROPN
bionys-549	187	14	,	,	PUNCT
bionys-549	187	15	ala299	ala299	PROPN
bionys-549	187	16	,	,	PUNCT
bionys-549	187	17	leu300	leu300	PROPN
bionys-549	187	18	(	(	PUNCT
bionys-549	187	19	fig	fig	NOUN
bionys-549	187	20	.	.	PUNCT
bionys-549	188	1	10a	10a	NOUN
bionys-549	188	2	and	and	CCONJ
bionys-549	188	3	fig	fig	NOUN
bionys-549	188	4	.	.	PUNCT
bionys-549	188	5	10b	10b	NOUN
bionys-549	188	6	)	)	PUNCT
bionys-549	188	7	had	have	VERB
bionys-549	188	8	a	a	DET
bionys-549	188	9	score	score	NOUN
bionys-549	188	10	fig	fig	NOUN
bionys-549	188	11	.	.	PUNCT
bionys-549	189	1	8	8	X
bionys-549	189	2	.	.	PUNCT
bionys-549	189	3	model	model	NOUN
bionys-549	189	4	aaarrr	aaarrr	PROPN
bionys-549	189	5	(	(	PUNCT
bionys-549	189	6	best	well	ADV
bionys-549	189	7	fit	fit	ADJ
bionys-549	189	8	a12	a12	NOUN
bionys-549	189	9	)	)	PUNCT
bionys-549	189	10	fig	fig	NOUN
bionys-549	189	11	.	.	PUNCT
bionys-549	190	1	9	9	X
bionys-549	190	2	.	.	X
bionys-549	190	3	final	final	ADJ
bionys-549	190	4	hit	hit	NOUN
bionys-549	190	5	(	(	PUNCT
bionys-549	190	6	left	leave	VERB
bionys-549	190	7	)	)	PUNCT
bionys-549	190	8	compared	compare	VERB
bionys-549	190	9	with	with	ADP
bionys-549	190	10	quercetin	quercetin	NOUN
bionys-549	190	11	129	129	NUM
bionys-549	190	12	of	of	ADP
bionys-549	190	13	-15.363	-15.363	PROPN
bionys-549	190	14	kcal	kcal	PROPN
bionys-549	190	15	/	/	SYM
bionys-549	190	16	mol	mol	PROPN
bionys-549	190	17	.	.	PUNCT
bionys-549	191	1	it	it	PRON
bionys-549	191	2	also	also	ADV
bionys-549	191	3	did	do	AUX
bionys-549	191	4	not	not	PART
bionys-549	191	5	interfere	interfere	VERB
bionys-549	191	6	with	with	ADP
bionys-549	191	7	the	the	DET
bionys-549	191	8	anionic	anionic	ADJ
bionys-549	191	9	region	region	NOUN
bionys-549	191	10	,	,	PUNCT
bionys-549	191	11	as	as	SCONJ
bionys-549	191	12	it	it	PRON
bionys-549	191	13	docked	dock	VERB
bionys-549	191	14	into	into	ADP
bionys-549	191	15	the	the	DET
bionys-549	191	16	active	active	ADJ
bionys-549	191	17	site	site	NOUN
bionys-549	191	18	entry	entry	NOUN
bionys-549	191	19	region	region	NOUN
bionys-549	191	20	,	,	PUNCT
bionys-549	191	21	which	which	PRON
bionys-549	191	22	forms	form	VERB
bionys-549	191	23	the	the	DET
bionys-549	191	24	pocket	pocket	NOUN
bionys-549	191	25	responsible	responsible	ADJ
bionys-549	191	26	for	for	ADP
bionys-549	191	27	specificity	specificity	NOUN
bionys-549	191	28	.	.	PUNCT
bionys-549	192	1	the	the	DET
bionys-549	192	2	molecule	molecule	NOUN
bionys-549	192	3	identified	identify	VERB
bionys-549	192	4	in	in	ADP
bionys-549	192	5	this	this	DET
bionys-549	192	6	study	study	NOUN
bionys-549	192	7	effectively	effectively	ADV
bionys-549	192	8	blocks	block	VERB
bionys-549	192	9	glucose	glucose	NOUN
bionys-549	192	10	entry	entry	NOUN
bionys-549	192	11	into	into	ADP
bionys-549	192	12	the	the	DET
bionys-549	192	13	active	active	ADJ
bionys-549	192	14	site	site	NOUN
bionys-549	192	15	,	,	PUNCT
bionys-549	192	16	covering	cover	VERB
bionys-549	192	17	almost	almost	ADV
bionys-549	192	18	the	the	DET
bionys-549	192	19	entire	entire	ADJ
bionys-549	192	20	entry	entry	NOUN
bionys-549	192	21	region	region	NOUN
bionys-549	192	22	while	while	SCONJ
bionys-549	192	23	leaving	leave	VERB
bionys-549	192	24	a	a	DET
bionys-549	192	25	small	small	ADJ
bionys-549	192	26	space	space	NOUN
bionys-549	192	27	that	that	PRON
bionys-549	192	28	prevents	prevent	VERB
bionys-549	192	29	glucose	glucose	NOUN
bionys-549	192	30	from	from	ADP
bionys-549	192	31	entering	enter	VERB
bionys-549	192	32	the	the	DET
bionys-549	192	33	anionic	anionic	ADJ
bionys-549	192	34	region	region	NOUN
bionys-549	192	35	.	.	PUNCT
bionys-549	193	1	however	however	ADV
bionys-549	193	2	,	,	PUNCT
bionys-549	193	3	our	our	PRON
bionys-549	193	4	final	final	ADJ
bionys-549	193	5	hit	hit	NOUN
bionys-549	193	6	has	have	VERB
bionys-549	193	7	a	a	DET
bionys-549	193	8	minor	minor	ADJ
bionys-549	193	9	drawback	drawback	NOUN
bionys-549	193	10	:	:	PUNCT
bionys-549	193	11	depending	depend	VERB
bionys-549	193	12	on	on	ADP
bionys-549	193	13	its	its	PRON
bionys-549	193	14	spatial	spatial	ADJ
bionys-549	193	15	orientation	orientation	NOUN
bionys-549	193	16	,	,	PUNCT
bionys-549	193	17	it	it	PRON
bionys-549	193	18	may	may	AUX
bionys-549	193	19	or	or	CCONJ
bionys-549	193	20	may	may	AUX
bionys-549	193	21	not	not	PART
bionys-549	193	22	permit	permit	VERB
bionys-549	193	23	the	the	DET
bionys-549	193	24	entry	entry	NOUN
bionys-549	193	25	of	of	ADP
bionys-549	193	26	toxic	toxic	ADJ
bionys-549	193	27	aldehydes	aldehyde	NOUN
bionys-549	193	28	necessary	necessary	ADJ
bionys-549	193	29	for	for	ADP
bionys-549	193	30	the	the	DET
bionys-549	193	31	detoxification	detoxification	NOUN
bionys-549	193	32	mechanism	mechanism	NOUN
bionys-549	193	33	.	.	PUNCT
bionys-549	194	1	recent	recent	ADJ
bionys-549	194	2	reports	report	NOUN
bionys-549	194	3	on	on	ADP
bionys-549	194	4	the	the	DET
bionys-549	194	5	identification	identification	NOUN
bionys-549	194	6	of	of	ADP
bionys-549	194	7	thiazolidindione	thiazolidindione	NOUN
bionys-549	194	8	through	through	ADP
bionys-549	194	9	docking	docking	NOUN
bionys-549	194	10	showed	show	VERB
bionys-549	194	11	interactions	interaction	NOUN
bionys-549	194	12	with	with	ADP
bionys-549	194	13	residues	residue	NOUN
bionys-549	194	14	trp111	trp111	ADJ
bionys-549	194	15	,	,	PUNCT
bionys-549	194	16	ala299	ala299	PROPN
bionys-549	194	17	,	,	PUNCT
bionys-549	194	18	leu300	leu300	PROPN
bionys-549	194	19	and	and	CCONJ
bionys-549	194	20	phe122	phe122	PROPN
bionys-549	194	21	located	locate	VERB
bionys-549	194	22	at	at	ADP
bionys-549	194	23	the	the	DET
bionys-549	194	24	specificity	specificity	NOUN
bionys-549	194	25	pocket	pocket	NOUN
bionys-549	194	26	,	,	PUNCT
bionys-549	194	27	which	which	PRON
bionys-549	194	28	also	also	ADV
bionys-549	194	29	confirms	confirm	VERB
bionys-549	194	30	our	our	PRON
bionys-549	194	31	finding	find	VERB
bionys-549	194	32	that	that	SCONJ
bionys-549	194	33	the	the	DET
bionys-549	194	34	interactions	interaction	NOUN
bionys-549	194	35	with	with	ADP
bionys-549	194	36	trp111	trp111	PROPN
bionys-549	194	37	is	be	AUX
bionys-549	194	38	critical	critical	ADJ
bionys-549	194	39	for	for	ADP
bionys-549	194	40	the	the	DET
bionys-549	194	41	inhibition	inhibition	NOUN
bionys-549	194	42	of	of	ADP
bionys-549	194	43	aldose	aldose	DET
bionys-549	194	44	reductase	reductase	NOUN
bionys-549	194	45	.	.	PUNCT
bionys-549	195	1	toxicity	toxicity	NOUN
bionys-549	195	2	prediction	prediction	NOUN
bionys-549	195	3	(	(	PUNCT
bionys-549	195	4	fig	fig	NOUN
bionys-549	195	5	.	.	PUNCT
bionys-549	195	6	11	11	NUM
bionys-549	195	7	)	)	PUNCT
bionys-549	195	8	for	for	ADP
bionys-549	195	9	the	the	DET
bionys-549	195	10	hit	hit	NOUN
bionys-549	195	11	compounds	compound	NOUN
bionys-549	195	12	using	use	VERB
bionys-549	195	13	protoxii	protoxii	NOUN
bionys-549	195	14	indicates	indicate	VERB
bionys-549	195	15	that	that	SCONJ
bionys-549	195	16	the	the	DET
bionys-549	195	17	compound	compound	NOUN
bionys-549	195	18	is	be	AUX
bionys-549	195	19	safe	safe	ADJ
bionys-549	195	20	for	for	ADP
bionys-549	195	21	oral	oral	ADJ
bionys-549	195	22	consumption	consumption	NOUN
bionys-549	195	23	as	as	SCONJ
bionys-549	195	24	it	it	PRON
bionys-549	195	25	falls	fall	VERB
bionys-549	195	26	under	under	ADP
bionys-549	195	27	category	category	NOUN
bionys-549	195	28	5	5	NUM
bionys-549	195	29	.	.	PUNCT
bionys-549	195	30	md	md	PROPN
bionys-549	195	31	simulation	simulation	PROPN
bionys-549	195	32	of	of	ADP
bionys-549	195	33	hit	hit	NOUN
bionys-549	195	34	using	use	VERB
bionys-549	195	35	the	the	DET
bionys-549	195	36	gromacs	gromac	NOUN
bionys-549	195	37	molecular	molecular	ADJ
bionys-549	195	38	dynamics	dynamic	NOUN
bionys-549	195	39	tool	tool	NOUN
bionys-549	195	40	,	,	PUNCT
bionys-549	195	41	a	a	DET
bionys-549	195	42	100ns	100ns	PROPN
bionys-549	195	43	md	md	PROPN
bionys-549	195	44	simulation	simulation	NOUN
bionys-549	195	45	of	of	ADP
bionys-549	195	46	the	the	DET
bionys-549	195	47	final	final	ADJ
bionys-549	195	48	hit	hit	NOUN
bionys-549	195	49	compound	compound	NOUN
bionys-549	195	50	complexed	complexe	VERB
bionys-549	195	51	with	with	ADP
bionys-549	195	52	aldose	aldose	ADJ
bionys-549	195	53	reductase	reductase	NOUN
bionys-549	195	54	enzyme	enzyme	NOUN
bionys-549	195	55	was	be	AUX
bionys-549	195	56	performed	perform	VERB
bionys-549	195	57	.	.	PUNCT
bionys-549	196	1	the	the	DET
bionys-549	196	2	stability	stability	NOUN
bionys-549	196	3	and	and	CCONJ
bionys-549	196	4	compactness	compactness	NOUN
bionys-549	196	5	of	of	ADP
bionys-549	196	6	the	the	DET
bionys-549	196	7	protein	protein	NOUN
bionys-549	196	8	structure	structure	NOUN
bionys-549	196	9	were	be	AUX
bionys-549	196	10	determined	determine	VERB
bionys-549	196	11	by	by	ADP
bionys-549	196	12	standard	standard	ADJ
bionys-549	196	13	protocols	protocol	NOUN
bionys-549	196	14	involving	involve	VERB
bionys-549	196	15	“	"	PUNCT
bionys-549	196	16	root	root	NOUN
bionys-549	196	17	mean	mean	ADJ
bionys-549	196	18	square	square	ADJ
bionys-549	196	19	deviation	deviation	NOUN
bionys-549	196	20	”	"	PUNCT
bionys-549	196	21	(	(	PUNCT
bionys-549	196	22	rmsd	rmsd	NOUN
bionys-549	196	23	)	)	PUNCT
bionys-549	196	24	,	,	PUNCT
bionys-549	196	25	“	"	PUNCT
bionys-549	196	26	root	root	NOUN
bionys-549	196	27	mean	mean	ADJ
bionys-549	196	28	square	square	ADJ
bionys-549	196	29	fluctuations	fluctuation	NOUN
bionys-549	196	30	”	"	PUNCT
bionys-549	196	31	(	(	PUNCT
bionys-549	196	32	rmsf	rmsf	NOUN
bionys-549	196	33	)	)	PUNCT
bionys-549	196	34	,	,	PUNCT
bionys-549	196	35	and	and	CCONJ
bionys-549	196	36	“	"	PUNCT
bionys-549	196	37	radius	radius	NOUN
bionys-549	196	38	of	of	ADP
bionys-549	196	39	gyration	gyration	NOUN
bionys-549	196	40	”	"	PUNCT
bionys-549	196	41	(	(	PUNCT
bionys-549	196	42	rg	rg	NOUN
bionys-549	196	43	)	)	PUNCT
bionys-549	196	44	.	.	PUNCT
bionys-549	197	1	the	the	DET
bionys-549	197	2	average	average	ADJ
bionys-549	197	3	rmsd	rmsd	NOUN
bionys-549	197	4	value	value	NOUN
bionys-549	197	5	is	be	AUX
bionys-549	197	6	~	~	PUNCT
bionys-549	197	7	0.08	0.08	NUM
bionys-549	197	8	nm	nm	NOUN
bionys-549	197	9	for	for	ADP
bionys-549	197	10	the	the	DET
bionys-549	197	11	backbone	backbone	NOUN
bionys-549	197	12	protein	protein	NOUN
bionys-549	197	13	(	(	PUNCT
bionys-549	197	14	fig	fig	NOUN
bionys-549	197	15	.	.	PUNCT
bionys-549	197	16	12a	12a	NOUN
bionys-549	197	17	)	)	PUNCT
bionys-549	197	18	.	.	PUNCT
bionys-549	198	1	higher	high	ADJ
bionys-549	198	2	rmsd	rmsd	NOUN
bionys-549	198	3	values	value	NOUN
bionys-549	198	4	indicate	indicate	VERB
bionys-549	198	5	that	that	SCONJ
bionys-549	198	6	protein	protein	NOUN
bionys-549	198	7	stability	stability	NOUN
bionys-549	198	8	decreases	decrease	VERB
bionys-549	198	9	,	,	PUNCT
bionys-549	198	10	whereas	whereas	SCONJ
bionys-549	198	11	a	a	DET
bionys-549	198	12	lower	low	ADJ
bionys-549	198	13	rmsd	rmsd	NOUN
bionys-549	198	14	value	value	NOUN
bionys-549	198	15	indicates	indicate	VERB
bionys-549	198	16	an	an	DET
bionys-549	198	17	increase	increase	NOUN
bionys-549	198	18	in	in	ADP
bionys-549	198	19	protein	protein	NOUN
bionys-549	198	20	stability	stability	NOUN
bionys-549	198	21	.	.	PUNCT
bionys-549	199	1	rmsf	rmsf	NOUN
bionys-549	199	2	calculates	calculate	VERB
bionys-549	199	3	the	the	DET
bionys-549	199	4	fluctuations	fluctuation	NOUN
bionys-549	199	5	of	of	ADP
bionys-549	199	6	individual	individual	ADJ
bionys-549	199	7	residue	residue	NOUN
bionys-549	199	8	in	in	ADP
bionys-549	199	9	presence	presence	NOUN
bionys-549	199	10	of	of	ADP
bionys-549	199	11	the	the	DET
bionys-549	199	12	ligands	ligand	NOUN
bionys-549	199	13	.	.	PUNCT
bionys-549	200	1	the	the	DET
bionys-549	200	2	macromolecule	macromolecule	NOUN
bionys-549	200	3	-	-	PUNCT
bionys-549	200	4	ligand	ligand	ADJ
bionys-549	200	5	complex	complex	NOUN
bionys-549	200	6	was	be	AUX
bionys-549	200	7	maintained	maintain	VERB
bionys-549	200	8	in	in	ADP
bionys-549	200	9	a	a	DET
bionys-549	200	10	triclinic	triclinic	ADJ
bionys-549	200	11	box	box	NOUN
bionys-549	200	12	with	with	ADP
bionys-549	200	13	dimensions	dimension	NOUN
bionys-549	200	14	of	of	ADP
bionys-549	200	15	43:54:47	43:54:47	NUM
bionys-549	200	16	and	and	CCONJ
bionys-549	200	17	solvated	solvate	VERB
bionys-549	200	18	using	use	VERB
bionys-549	200	19	the	the	DET
bionys-549	200	20	simple	simple	ADJ
bionys-549	200	21	point	point	NOUN
bionys-549	200	22	charge	charge	NOUN
bionys-549	200	23	(	(	PUNCT
bionys-549	200	24	spc	spc	PROPN
bionys-549	200	25	)	)	PUNCT
bionys-549	200	26	water	water	NOUN
bionys-549	200	27	model	model	NOUN
bionys-549	200	28	,	,	PUNCT
bionys-549	200	29	neutralized	neutralize	VERB
bionys-549	200	30	with	with	ADP
bionys-549	200	31	a	a	DET
bionys-549	200	32	0.15	0.15	NUM
bionys-549	200	33	m	m	NOUN
bionys-549	200	34	nacl	nacl	ADJ
bionys-549	200	35	salt	salt	NOUN
bionys-549	200	36	concentration	concentration	NOUN
bionys-549	200	37	.	.	PUNCT
bionys-549	201	1	the	the	DET
bionys-549	201	2	opls	opls	PROPN
bionys-549	201	3	/	/	SYM
bionys-549	201	4	aa	aa	PROPN
bionys-549	201	5	force	force	NOUN
bionys-549	201	6	field	field	NOUN
bionys-549	201	7	was	be	AUX
bionys-549	201	8	employed	employ	VERB
bionys-549	201	9	to	to	PART
bionys-549	201	10	parameterize	parameterize	VERB
bionys-549	201	11	the	the	DET
bionys-549	201	12	macromolecule	macromolecule	NOUN
bionys-549	201	13	and	and	CCONJ
bionys-549	201	14	its	its	PRON
bionys-549	201	15	ligands	ligand	NOUN
bionys-549	201	16	.	.	PUNCT
bionys-549	202	1	energy	energy	NOUN
bionys-549	202	2	minimization	minimization	NOUN
bionys-549	202	3	was	be	AUX
bionys-549	202	4	performed	perform	VERB
bionys-549	202	5	using	use	VERB
bionys-549	202	6	the	the	DET
bionys-549	202	7	steepest	steep	ADJ
bionys-549	202	8	descent	descent	NOUN
bionys-549	202	9	technique	technique	NOUN
bionys-549	202	10	to	to	PART
bionys-549	202	11	eliminate	eliminate	VERB
bionys-549	202	12	steric	steric	ADJ
bionys-549	202	13	disturbances	disturbance	NOUN
bionys-549	202	14	between	between	ADP
bionys-549	202	15	the	the	DET
bionys-549	202	16	macromolecule	macromolecule	NOUN
bionys-549	202	17	and	and	CCONJ
bionys-549	202	18	the	the	DET
bionys-549	202	19	ligand	ligand	NOUN
bionys-549	202	20	.	.	PUNCT
bionys-549	203	1	the	the	DET
bionys-549	203	2	leapfrog	leapfrog	ADJ
bionys-549	203	3	and	and	CCONJ
bionys-549	203	4	two	two	NUM
bionys-549	203	5	-	-	PUNCT
bionys-549	203	6	phase	phase	NOUN
bionys-549	203	7	ensemble	ensemble	ADJ
bionys-549	203	8	equilibration	equilibration	NOUN
bionys-549	203	9	algorithms	algorithm	NOUN
bionys-549	203	10	were	be	AUX
bionys-549	203	11	utilized	utilize	VERB
bionys-549	203	12	for	for	ADP
bionys-549	203	13	integration	integration	NOUN
bionys-549	203	14	in	in	ADP
bionys-549	203	15	the	the	DET
bionys-549	203	16	nvt	nvt	PROPN
bionys-549	203	17	and	and	CCONJ
bionys-549	203	18	npt	npt	PROPN
bionys-549	203	19	at	at	ADP
bionys-549	203	20	fixed	fix	VERB
bionys-549	203	21	temperature	temperature	NOUN
bionys-549	203	22	(	(	PUNCT
bionys-549	203	23	300	300	NUM
bionys-549	203	24	k	k	NOUN
bionys-549	203	25	)	)	PUNCT
bionys-549	203	26	and	and	CCONJ
bionys-549	203	27	pressure	pressure	NOUN
bionys-549	203	28	(	(	PUNCT
bionys-549	203	29	1	1	NUM
bionys-549	203	30	bar	bar	NOUN
bionys-549	203	31	)	)	PUNCT
bionys-549	203	32	.	.	PUNCT
bionys-549	204	1	after	after	ADP
bionys-549	204	2	initialization	initialization	NOUN
bionys-549	204	3	and	and	CCONJ
bionys-549	204	4	equilibration	equilibration	NOUN
bionys-549	204	5	,	,	PUNCT
bionys-549	204	6	molecular	molecular	ADJ
bionys-549	204	7	dynamics	dynamic	NOUN
bionys-549	204	8	simulations	simulation	NOUN
bionys-549	204	9	were	be	AUX
bionys-549	204	10	conducted	conduct	VERB
bionys-549	204	11	for	for	ADP
bionys-549	204	12	100	100	NUM
bionys-549	204	13	ns	ns	NUM
bionys-549	204	14	,	,	PUNCT
bionys-549	204	15	with	with	ADP
bionys-549	204	16	data	datum	NOUN
bionys-549	204	17	collected	collect	VERB
bionys-549	204	18	to	to	PART
bionys-549	204	19	determine	determine	VERB
bionys-549	204	20	rmsd	rmsd	NOUN
bionys-549	204	21	,	,	PUNCT
bionys-549	204	22	rmsf	rmsf	NOUN
bionys-549	204	23	,	,	PUNCT
bionys-549	204	24	and	and	CCONJ
bionys-549	204	25	hydrogen	hydrogen	NOUN
bionys-549	204	26	bonding	bonding	NOUN
bionys-549	204	27	.	.	PUNCT
bionys-549	205	1	the	the	DET
bionys-549	205	2	rmsd	rmsd	NOUN
bionys-549	205	3	and	and	CCONJ
bionys-549	205	4	rmsf	rmsf	NOUN
bionys-549	205	5	for	for	ADP
bionys-549	205	6	the	the	DET
bionys-549	205	7	hit	hit	VERB
bionys-549	205	8	-	-	PUNCT
bionys-549	205	9	aldose	aldose	NOUN
bionys-549	205	10	reductase	reductase	NOUN
bionys-549	205	11	complex	complex	NOUN
bionys-549	205	12	(	(	PUNCT
bionys-549	205	13	fig	fig	NOUN
bionys-549	205	14	.	.	PUNCT
bionys-549	205	15	12b	12b	NOUN
bionys-549	205	16	)	)	PUNCT
bionys-549	205	17	showed	show	VERB
bionys-549	205	18	an	an	DET
bionys-549	205	19	average	average	ADJ
bionys-549	205	20	rmsd	rmsd	NOUN
bionys-549	205	21	of	of	ADP
bionys-549	205	22	0.1	0.1	NUM
bionys-549	205	23	nm	nm	NOUN
bionys-549	205	24	during	during	ADP
bionys-549	205	25	the	the	DET
bionys-549	205	26	period	period	NOUN
bionys-549	205	27	from	from	ADP
bionys-549	205	28	20	20	NUM
bionys-549	205	29	ns	ns	NUM
bionys-549	205	30	to	to	PART
bionys-549	205	31	60	60	NUM
bionys-549	205	32	ns	ns	NUM
bionys-549	205	33	,	,	PUNCT
bionys-549	205	34	indicating	indicate	VERB
bionys-549	205	35	that	that	SCONJ
bionys-549	205	36	the	the	DET
bionys-549	205	37	stability	stability	NOUN
bionys-549	205	38	of	of	ADP
bionys-549	205	39	the	the	DET
bionys-549	205	40	complex	complex	NOUN
bionys-549	205	41	was	be	AUX
bionys-549	205	42	biologica	biologica	PROPN
bionys-549	205	43	nyssana	nyssana	PROPN
bionys-549	205	44	●	●	PUNCT
bionys-549	205	45	15	15	NUM
bionys-549	205	46	(	(	PUNCT
bionys-549	205	47	2	2	NUM
bionys-549	205	48	)	)	PUNCT
bionys-549	205	49	december	december	PROPN
bionys-549	205	50	2024	2024	NUM
bionys-549	205	51	:	:	PUNCT
bionys-549	205	52	nagarajan	nagarajan	NOUN
bionys-549	205	53	et	et	PROPN
bionys-549	205	54	al	al	PROPN
bionys-549	205	55	.	.	PUNCT
bionys-549	206	1	●	●	PUNCT
bionys-549	206	2	beyond	beyond	ADP
bionys-549	206	3	boundaries	boundary	NOUN
bionys-549	206	4	:	:	PUNCT
bionys-549	206	5	pioneering	pioneer	VERB
bionys-549	206	6	discoveries	discovery	NOUN
bionys-549	206	7	in	in	ADP
bionys-549	206	8	aldose	aldose	PRON
bionys-549	206	9	reductase	reductase	NOUN
bionys-549	206	10	inhibition	inhibition	NOUN
bionys-549	206	11	for	for	ADP
bionys-549	206	12	diabetic	diabetic	ADJ
bionys-549	206	13	neuropathy	neuropathy	ADJ
bionys-549	206	14	fig	fig	NOUN
bionys-549	206	15	.	.	PUNCT
bionys-549	207	1	10	10	NUM
bionys-549	207	2	.	.	X
bionys-549	207	3	2d	2d	NUM
bionys-549	207	4	interaction	interaction	NOUN
bionys-549	207	5	for	for	ADP
bionys-549	207	6	the	the	DET
bionys-549	207	7	hit	hit	VERB
bionys-549	207	8	molecule	molecule	NOUN
bionys-549	207	9	and	and	CCONJ
bionys-549	207	10	aldose	aldose	ADJ
bionys-549	207	11	reductase	reductase	NOUN
bionys-549	207	12	(	(	PUNCT
bionys-549	207	13	a	a	NOUN
bionys-549	207	14	)	)	PUNCT
bionys-549	207	15	.	.	PUNCT
bionys-549	208	1	different	different	ADJ
bionys-549	208	2	poses	pose	NOUN
bionys-549	208	3	of	of	ADP
bionys-549	208	4	hit	hit	VERB
bionys-549	208	5	molecule	molecule	NOUN
bionys-549	208	6	,	,	PUNCT
bionys-549	208	7	occupying	occupy	VERB
bionys-549	208	8	the	the	DET
bionys-549	208	9	specificity	specificity	NOUN
bionys-549	208	10	pocket	pocket	NOUN
bionys-549	208	11	(	(	PUNCT
bionys-549	208	12	left	left	ADJ
bionys-549	208	13	)	)	PUNCT
bionys-549	208	14	making	make	VERB
bionys-549	208	15	interactions	interaction	NOUN
bionys-549	208	16	(	(	PUNCT
bionys-549	208	17	left	left	ADJ
bionys-549	208	18	,	,	PUNCT
bionys-549	208	19	right	right	ADJ
bionys-549	208	20	)	)	PUNCT
bionys-549	208	21	with	with	ADP
bionys-549	208	22	val297	val297	PROPN
bionys-549	208	23	,	,	PUNCT
bionys-549	208	24	ala299	ala299	PROPN
bionys-549	208	25	and	and	CCONJ
bionys-549	208	26	leu300	leu300	PROPN
bionys-549	208	27	at	at	ADP
bionys-549	208	28	distances	distance	NOUN
bionys-549	208	29	of	of	ADP
bionys-549	208	30	2.2ǻ	2.2ǻ	NUM
bionys-549	208	31	,	,	PUNCT
bionys-549	208	32	2.9ǻ	2.9ǻ	NUM
bionys-549	208	33	and	and	CCONJ
bionys-549	208	34	2.0ǻ	2.0ǻ	NUM
bionys-549	208	35	respectively	respectively	ADV
bionys-549	208	36	(	(	PUNCT
bionys-549	208	37	b	b	X
bionys-549	208	38	)	)	PUNCT
bionys-549	208	39	130	130	NUM
bionys-549	208	40	biologica	biologica	NOUN
bionys-549	208	41	nyssana	nyssana	PROPN
bionys-549	209	1	●	●	PUNCT
bionys-549	209	2	15	15	NUM
bionys-549	209	3	(	(	PUNCT
bionys-549	209	4	2	2	NUM
bionys-549	209	5	)	)	PUNCT
bionys-549	209	6	december	december	PROPN
bionys-549	209	7	2024	2024	NUM
bionys-549	209	8	:	:	PUNCT
bionys-549	209	9	nagarajan	nagarajan	NOUN
bionys-549	209	10	et	et	PROPN
bionys-549	209	11	al	al	PROPN
bionys-549	209	12	.	.	PUNCT
bionys-549	210	1	●	●	PUNCT
bionys-549	210	2	beyond	beyond	ADP
bionys-549	210	3	boundaries	boundary	NOUN
bionys-549	210	4	:	:	PUNCT
bionys-549	210	5	pioneering	pioneer	VERB
bionys-549	210	6	discoveries	discovery	NOUN
bionys-549	210	7	in	in	ADP
bionys-549	210	8	aldose	aldose	PRON
bionys-549	210	9	reductase	reductase	NOUN
bionys-549	210	10	inhibition	inhibition	NOUN
bionys-549	210	11	for	for	ADP
bionys-549	210	12	diabetic	diabetic	ADJ
bionys-549	210	13	neuropathy	neuropathy	ADJ
bionys-549	210	14	fig	fig	NOUN
bionys-549	210	15	.	.	PUNCT
bionys-549	211	1	11	11	NUM
bionys-549	211	2	.	.	PUNCT
bionys-549	211	3	toxicity	toxicity	NOUN
bionys-549	211	4	prediction	prediction	NOUN
bionys-549	211	5	for	for	ADP
bionys-549	211	6	the	the	DET
bionys-549	211	7	hit	hit	VERB
bionys-549	211	8	molecule	molecule	NOUN
bionys-549	211	9	fig	fig	NOUN
bionys-549	211	10	.	.	PUNCT
bionys-549	212	1	12	12	NUM
bionys-549	212	2	.	.	PUNCT
bionys-549	212	3	rmsd	rmsd	NOUN
bionys-549	212	4	of	of	ADP
bionys-549	212	5	protein	protein	NOUN
bionys-549	212	6	with	with	ADP
bionys-549	212	7	hit	hit	VERB
bionys-549	212	8	compound	compound	NOUN
bionys-549	212	9	(	(	PUNCT
bionys-549	212	10	a	a	NOUN
bionys-549	212	11	)	)	PUNCT
bionys-549	212	12	.	.	PUNCT
bionys-549	213	1	rmsf	rmsf	NOUN
bionys-549	213	2	of	of	ADP
bionys-549	213	3	protein	protein	NOUN
bionys-549	213	4	with	with	ADP
bionys-549	213	5	hit	hit	VERB
bionys-549	213	6	compound	compound	NOUN
bionys-549	213	7	(	(	PUNCT
bionys-549	213	8	b	b	NOUN
bionys-549	213	9	)	)	PUNCT
bionys-549	213	10	gradually	gradually	ADV
bionys-549	213	11	maintained	maintain	VERB
bionys-549	213	12	,	,	PUNCT
bionys-549	213	13	with	with	ADP
bionys-549	213	14	only	only	ADJ
bionys-549	213	15	slight	slight	ADJ
bionys-549	213	16	deviations	deviation	NOUN
bionys-549	213	17	from	from	ADP
bionys-549	213	18	the	the	DET
bionys-549	213	19	initial	initial	ADJ
bionys-549	213	20	simulation	simulation	NOUN
bionys-549	213	21	(	(	PUNCT
bionys-549	213	22	0.05	0.05	NUM
bionys-549	213	23	nm	nm	NOUN
bionys-549	213	24	to	to	ADP
bionys-549	213	25	0.06	0.06	NUM
bionys-549	213	26	nm	nm	NOUN
bionys-549	213	27	)	)	PUNCT
bionys-549	213	28	.	.	PUNCT
bionys-549	214	1	the	the	DET
bionys-549	214	2	simulation	simulation	NOUN
bionys-549	214	3	results	result	NOUN
bionys-549	214	4	indicated	indicate	VERB
bionys-549	214	5	that	that	SCONJ
bionys-549	214	6	the	the	DET
bionys-549	214	7	complex	complex	NOUN
bionys-549	214	8	remained	remain	VERB
bionys-549	214	9	stable	stable	ADJ
bionys-549	214	10	from	from	ADP
bionys-549	214	11	25	25	NUM
bionys-549	214	12	ns	ns	NUM
bionys-549	214	13	to	to	ADP
bionys-549	214	14	100	100	NUM
bionys-549	214	15	ns	ns	NUM
bionys-549	214	16	,	,	PUNCT
bionys-549	214	17	which	which	PRON
bionys-549	214	18	is	be	AUX
bionys-549	214	19	considered	consider	VERB
bionys-549	214	20	good	good	ADJ
bionys-549	214	21	stability	stability	NOUN
bionys-549	214	22	throughout	throughout	ADP
bionys-549	214	23	the	the	DET
bionys-549	214	24	simulation	simulation	NOUN
bionys-549	214	25	period	period	NOUN
bionys-549	214	26	.	.	PUNCT
bionys-549	215	1	the	the	DET
bionys-549	215	2	rmsf	rmsf	NOUN
bionys-549	215	3	analysis	analysis	NOUN
bionys-549	215	4	revealed	reveal	VERB
bionys-549	215	5	an	an	DET
bionys-549	215	6	average	average	ADJ
bionys-549	215	7	fluctuation	fluctuation	NOUN
bionys-549	215	8	rate	rate	NOUN
bionys-549	215	9	of	of	ADP
bionys-549	215	10	0.1	0.1	NUM
bionys-549	215	11	nm	nm	NOUN
bionys-549	215	12	,	,	PUNCT
bionys-549	215	13	confirming	confirm	VERB
bionys-549	215	14	that	that	SCONJ
bionys-549	215	15	the	the	DET
bionys-549	215	16	complex	complex	NOUN
bionys-549	215	17	maintained	maintain	VERB
bionys-549	215	18	structural	structural	ADJ
bionys-549	215	19	stability	stability	NOUN
bionys-549	215	20	with	with	ADP
bionys-549	215	21	the	the	DET
bionys-549	215	22	ligand	ligand	NOUN
bionys-549	215	23	bound	bind	VERB
bionys-549	215	24	to	to	ADP
bionys-549	215	25	it	it	PRON
bionys-549	215	26	.	.	PUNCT
bionys-549	216	1	a	a	DET
bionys-549	216	2	study	study	NOUN
bionys-549	216	3	by	by	ADP
bionys-549	216	4	kondhare	kondhare	PROPN
bionys-549	216	5	et	et	PROPN
bionys-549	216	6	al	al	PROPN
bionys-549	216	7	.	.	PROPN
bionys-549	216	8	(	(	PUNCT
bionys-549	216	9	2022	2022	NUM
bionys-549	216	10	)	)	PUNCT
bionys-549	216	11	describes	describe	VERB
bionys-549	216	12	the	the	DET
bionys-549	216	13	aldose	aldose	ADJ
bionys-549	216	14	reductase	reductase	NOUN
bionys-549	216	15	inhibitory	inhibitory	ADJ
bionys-549	216	16	activity	activity	NOUN
bionys-549	216	17	of	of	ADP
bionys-549	216	18	alkannin	alkannin	PROPN
bionys-549	216	19	(	(	PUNCT
bionys-549	216	20	fig	fig	NOUN
bionys-549	216	21	.	.	PUNCT
bionys-549	217	1	13	13	NUM
bionys-549	217	2	)	)	PUNCT
bionys-549	217	3	,	,	PUNCT
bionys-549	217	4	a	a	DET
bionys-549	217	5	naphthoquinone	naphthoquinone	NOUN
bionys-549	217	6	-	-	PUNCT
bionys-549	217	7	based	base	VERB
bionys-549	217	8	compound	compound	NOUN
bionys-549	217	9	from	from	ADP
bionys-549	217	10	plants	plant	NOUN
bionys-549	217	11	in	in	ADP
bionys-549	217	12	the	the	DET
bionys-549	217	13	boraginaceae	boraginaceae	PROPN
bionys-549	217	14	family	family	NOUN
bionys-549	217	15	.	.	PUNCT
bionys-549	218	1	docking	dock	VERB
bionys-549	218	2	studies	study	NOUN
bionys-549	218	3	showed	show	VERB
bionys-549	218	4	that	that	SCONJ
bionys-549	218	5	alkannin	alkannin	PROPN
bionys-549	218	6	formed	form	VERB
bionys-549	218	7	hydrogen	hydrogen	NOUN
bionys-549	218	8	bonds	bond	NOUN
bionys-549	218	9	with	with	ADP
bionys-549	218	10	val297	val297	PROPN
bionys-549	218	11	,	,	PUNCT
bionys-549	218	12	ala299	ala299	PROPN
bionys-549	218	13	,	,	PUNCT
bionys-549	218	14	leu300	leu300	PROPN
bionys-549	218	15	,	,	PUNCT
bionys-549	218	16	and	and	CCONJ
bionys-549	218	17	ser302	ser302	PROPN
bionys-549	218	18	,	,	PUNCT
bionys-549	218	19	along	along	ADP
bionys-549	218	20	with	with	ADP
bionys-549	218	21	hydrophobic	hydrophobic	NOUN
bionys-549	218	22	interactions	interaction	NOUN
bionys-549	218	23	(	(	PUNCT
bionys-549	218	24	trp20	trp20	PROPN
bionys-549	218	25	,	,	PUNCT
bionys-549	218	26	val47	val47	ADJ
bionys-549	218	27	,	,	PUNCT
bionys-549	218	28	fig	fig	NOUN
bionys-549	218	29	.	.	PUNCT
bionys-549	219	1	13	13	NUM
bionys-549	219	2	.	.	X
bionys-549	220	1	alkannin	alkannin	PROPN
bionys-549	220	2	131	131	NUM
bionys-549	220	3	biologica	biologica	PROPN
bionys-549	220	4	nyssana	nyssana	PROPN
bionys-549	221	1	●	●	PUNCT
bionys-549	221	2	15	15	NUM
bionys-549	221	3	(	(	PUNCT
bionys-549	221	4	2	2	NUM
bionys-549	221	5	)	)	PUNCT
bionys-549	221	6	december	december	PROPN
bionys-549	221	7	2024	2024	NUM
bionys-549	221	8	:	:	PUNCT
bionys-549	221	9	nagarajan	nagarajan	NOUN
bionys-549	221	10	et	et	PROPN
bionys-549	221	11	al	al	PROPN
bionys-549	221	12	.	.	PUNCT
bionys-549	222	1	●	●	PUNCT
bionys-549	222	2	beyond	beyond	ADP
bionys-549	222	3	boundaries	boundary	NOUN
bionys-549	222	4	:	:	PUNCT
bionys-549	222	5	pioneering	pioneer	VERB
bionys-549	222	6	discoveries	discovery	NOUN
bionys-549	222	7	in	in	ADP
bionys-549	222	8	aldose	aldose	PRON
bionys-549	222	9	reductase	reductase	NOUN
bionys-549	222	10	inhibition	inhibition	NOUN
bionys-549	222	11	for	for	ADP
bionys-549	222	12	diabetic	diabetic	ADJ
bionys-549	222	13	neuropathy	neuropathy	ADJ
bionys-549	222	14	tyr48	tyr48	NOUN
bionys-549	222	15	,	,	PUNCT
bionys-549	222	16	trp79	trp79	ADJ
bionys-549	222	17	,	,	PUNCT
bionys-549	222	18	trp111	trp111	PROPN
bionys-549	222	19	,	,	PUNCT
bionys-549	222	20	phe122	phe122	PROPN
bionys-549	222	21	,	,	PUNCT
bionys-549	222	22	trp219	trp219	PROPN
bionys-549	222	23	,	,	PUNCT
bionys-549	222	24	val297	val297	PROPN
bionys-549	222	25	,	,	PUNCT
bionys-549	222	26	cys298	cys298	PROPN
bionys-549	222	27	,	,	PUNCT
bionys-549	222	28	ala299	ala299	PROPN
bionys-549	222	29	,	,	PUNCT
bionys-549	222	30	leu300	leu300	PROPN
bionys-549	222	31	,	,	PUNCT
bionys-549	222	32	and	and	CCONJ
bionys-549	222	33	leu301	leu301	PROPN
bionys-549	222	34	)	)	PUNCT
bionys-549	222	35	.	.	PUNCT
bionys-549	223	1	the	the	DET
bionys-549	223	2	results	result	NOUN
bionys-549	223	3	from	from	ADP
bionys-549	223	4	in	in	ADP
bionys-549	223	5	vitro	vitro	X
bionys-549	223	6	studies	study	NOUN
bionys-549	223	7	show	show	VERB
bionys-549	223	8	a	a	DET
bionys-549	223	9	potent	potent	ADJ
bionys-549	223	10	dose	dose	NOUN
bionys-549	223	11	-	-	PUNCT
bionys-549	223	12	dependent	dependent	ADJ
bionys-549	223	13	inhibitory	inhibitory	ADJ
bionys-549	223	14	activity	activity	NOUN
bionys-549	223	15	for	for	ADP
bionys-549	223	16	aldose	aldose	DET
bionys-549	223	17	reductase	reductase	NOUN
bionys-549	223	18	at	at	ADP
bionys-549	223	19	22.77	22.77	NUM
bionys-549	223	20	μm	μm	NOUN
bionys-549	223	21	.	.	PUNCT
bionys-549	224	1	given	give	VERB
bionys-549	224	2	the	the	DET
bionys-549	224	3	recent	recent	ADJ
bionys-549	224	4	emphasis	emphasis	NOUN
bionys-549	224	5	on	on	ADP
bionys-549	224	6	identifying	identify	VERB
bionys-549	224	7	effective	effective	ADJ
bionys-549	224	8	aldose	aldose	ADJ
bionys-549	224	9	reductase	reductase	NOUN
bionys-549	224	10	inhibitors	inhibitor	NOUN
bionys-549	224	11	,	,	PUNCT
bionys-549	224	12	our	our	PRON
bionys-549	224	13	results	result	NOUN
bionys-549	224	14	represent	represent	VERB
bionys-549	224	15	a	a	DET
bionys-549	224	16	starting	starting	NOUN
bionys-549	224	17	point	point	NOUN
bionys-549	224	18	for	for	ADP
bionys-549	224	19	the	the	DET
bionys-549	224	20	extensive	extensive	ADJ
bionys-549	224	21	research	research	NOUN
bionys-549	224	22	needed	need	VERB
bionys-549	224	23	to	to	PART
bionys-549	224	24	achieve	achieve	VERB
bionys-549	224	25	this	this	DET
bionys-549	224	26	goal	goal	NOUN
bionys-549	224	27	.	.	PUNCT
bionys-549	225	1	furthermore	furthermore	ADV
bionys-549	225	2	,	,	PUNCT
bionys-549	225	3	the	the	DET
bionys-549	225	4	hit	hit	ADJ
bionys-549	225	5	molecule	molecule	NOUN
bionys-549	225	6	identified	identify	VERB
bionys-549	225	7	here	here	ADV
bionys-549	225	8	does	do	AUX
bionys-549	225	9	not	not	PART
bionys-549	225	10	extend	extend	VERB
bionys-549	225	11	into	into	ADP
bionys-549	225	12	the	the	DET
bionys-549	225	13	anionic	anionic	ADJ
bionys-549	225	14	region	region	NOUN
bionys-549	225	15	responsible	responsible	ADJ
bionys-549	225	16	for	for	ADP
bionys-549	225	17	detoxifying	detoxify	VERB
bionys-549	225	18	toxic	toxic	ADJ
bionys-549	225	19	aldehydes	aldehyde	NOUN
bionys-549	225	20	produced	produce	VERB
bionys-549	225	21	by	by	ADP
bionys-549	225	22	the	the	DET
bionys-549	225	23	lipid	lipid	NOUN
bionys-549	225	24	pathway	pathway	NOUN
bionys-549	225	25	.	.	PUNCT
bionys-549	226	1	this	this	PRON
bionys-549	226	2	is	be	AUX
bionys-549	226	3	a	a	DET
bionys-549	226	4	crucial	crucial	ADJ
bionys-549	226	5	criterion	criterion	NOUN
bionys-549	226	6	for	for	ADP
bionys-549	226	7	an	an	DET
bionys-549	226	8	aldose	aldose	ADJ
bionys-549	226	9	reductase	reductase	NOUN
bionys-549	226	10	inhibitor	inhibitor	NOUN
bionys-549	226	11	,	,	PUNCT
bionys-549	226	12	as	as	SCONJ
bionys-549	226	13	it	it	PRON
bionys-549	226	14	prevents	prevent	VERB
bionys-549	226	15	glucose	glucose	NOUN
bionys-549	226	16	from	from	ADP
bionys-549	226	17	entering	enter	VERB
bionys-549	226	18	the	the	DET
bionys-549	226	19	active	active	ADJ
bionys-549	226	20	site	site	NOUN
bionys-549	226	21	.	.	PUNCT
bionys-549	227	1	however	however	ADV
bionys-549	227	2	,	,	PUNCT
bionys-549	227	3	the	the	DET
bionys-549	227	4	binding	bind	VERB
bionys-549	227	5	orientation	orientation	NOUN
bionys-549	227	6	of	of	ADP
bionys-549	227	7	this	this	DET
bionys-549	227	8	molecule	molecule	NOUN
bionys-549	227	9	may	may	AUX
bionys-549	227	10	allow	allow	VERB
bionys-549	227	11	or	or	CCONJ
bionys-549	227	12	restrict	restrict	VERB
bionys-549	227	13	the	the	DET
bionys-549	227	14	entry	entry	NOUN
bionys-549	227	15	of	of	ADP
bionys-549	227	16	toxic	toxic	ADJ
bionys-549	227	17	aldehydes	aldehyde	NOUN
bionys-549	227	18	into	into	ADP
bionys-549	227	19	the	the	DET
bionys-549	227	20	pocket	pocket	NOUN
bionys-549	227	21	.	.	PUNCT
bionys-549	228	1	specifically	specifically	ADV
bionys-549	228	2	,	,	PUNCT
bionys-549	228	3	it	it	PRON
bionys-549	228	4	may	may	AUX
bionys-549	228	5	permit	permit	VERB
bionys-549	228	6	the	the	DET
bionys-549	228	7	entry	entry	NOUN
bionys-549	228	8	of	of	ADP
bionys-549	228	9	methylglyoxal	methylglyoxal	ADJ
bionys-549	228	10	due	due	ADP
bionys-549	228	11	to	to	ADP
bionys-549	228	12	its	its	PRON
bionys-549	228	13	size	size	NOUN
bionys-549	228	14	and	and	CCONJ
bionys-549	228	15	volume	volume	NOUN
bionys-549	228	16	,	,	PUNCT
bionys-549	228	17	while	while	SCONJ
bionys-549	228	18	it	it	PRON
bionys-549	228	19	does	do	AUX
bionys-549	228	20	not	not	PART
bionys-549	228	21	allow	allow	VERB
bionys-549	228	22	glyceraldehyde	glyceraldehyde	PROPN
bionys-549	228	23	,	,	PUNCT
bionys-549	228	24	a	a	DET
bionys-549	228	25	four	four	NUM
bionys-549	228	26	-	-	PUNCT
bionys-549	228	27	carbon	carbon	NOUN
bionys-549	228	28	linear	linear	NOUN
bionys-549	228	29	molecule	molecule	NOUN
bionys-549	228	30	,	,	PUNCT
bionys-549	228	31	to	to	PART
bionys-549	228	32	enter	enter	VERB
bionys-549	228	33	.	.	PUNCT
bionys-549	229	1	conclusion	conclusion	VERB
bionys-549	229	2	molecular	molecular	ADJ
bionys-549	229	3	ligand	ligand	NOUN
bionys-549	229	4	docking	docking	NOUN
bionys-549	229	5	into	into	ADP
bionys-549	229	6	three	three	NUM
bionys-549	229	7	regions	region	NOUN
bionys-549	229	8	anionic	anionic	ADJ
bionys-549	229	9	region	region	NOUN
bionys-549	229	10	,	,	PUNCT
bionys-549	229	11	specificity	specificity	NOUN
bionys-549	229	12	region	region	NOUN
bionys-549	229	13	,	,	PUNCT
bionys-549	229	14	and	and	CCONJ
bionys-549	229	15	active	active	ADJ
bionys-549	229	16	site	site	NOUN
bionys-549	229	17	region	region	NOUN
bionys-549	229	18	,	,	PUNCT
bionys-549	229	19	allowed	allow	VERB
bionys-549	229	20	the	the	DET
bionys-549	229	21	identification	identification	NOUN
bionys-549	229	22	of	of	ADP
bionys-549	229	23	possible	possible	ADJ
bionys-549	229	24	inhibitors	inhibitor	NOUN
bionys-549	229	25	that	that	PRON
bionys-549	229	26	selectively	selectively	ADV
bionys-549	229	27	bind	bind	VERB
bionys-549	229	28	to	to	ADP
bionys-549	229	29	the	the	DET
bionys-549	229	30	specificity	specificity	NOUN
bionys-549	229	31	region	region	NOUN
bionys-549	229	32	.	.	PUNCT
bionys-549	230	1	the	the	DET
bionys-549	230	2	hit	hit	VERB
bionys-549	230	3	molecule	molecule	NOUN
bionys-549	230	4	(	(	PUNCT
bionys-549	230	5	mol_7921	mol_7921	NUM
bionys-549	230	6	)	)	PUNCT
bionys-549	230	7	bears	bear	VERB
bionys-549	230	8	much	much	ADJ
bionys-549	230	9	similarity	similarity	NOUN
bionys-549	230	10	to	to	ADP
bionys-549	230	11	a	a	DET
bionys-549	230	12	flavonoid	flavonoid	NOUN
bionys-549	230	13	and	and	CCONJ
bionys-549	230	14	can	can	AUX
bionys-549	230	15	therefore	therefore	ADV
bionys-549	230	16	be	be	AUX
bionys-549	230	17	considered	consider	VERB
bionys-549	230	18	a	a	DET
bionys-549	230	19	good	good	ADJ
bionys-549	230	20	starting	starting	NOUN
bionys-549	230	21	point	point	NOUN
bionys-549	230	22	for	for	ADP
bionys-549	230	23	future	future	ADJ
bionys-549	230	24	studies	study	NOUN
bionys-549	230	25	.	.	PUNCT
bionys-549	231	1	unlike	unlike	ADP
bionys-549	231	2	the	the	DET
bionys-549	231	3	other	other	ADJ
bionys-549	231	4	compounds	compound	NOUN
bionys-549	231	5	that	that	PRON
bionys-549	231	6	we	we	PRON
bionys-549	231	7	analyzed	analyze	VERB
bionys-549	231	8	and	and	CCONJ
bionys-549	231	9	studied	study	VERB
bionys-549	231	10	in	in	ADP
bionys-549	231	11	our	our	PRON
bionys-549	231	12	earlier	early	ADJ
bionys-549	231	13	workflow	workflow	NOUN
bionys-549	231	14	,	,	PUNCT
bionys-549	231	15	this	this	DET
bionys-549	231	16	molecule	molecule	NOUN
bionys-549	231	17	(	(	PUNCT
bionys-549	231	18	mol_7921	mol_7921	NUM
bionys-549	231	19	,	,	PUNCT
bionys-549	231	20	fig	fig	NOUN
bionys-549	231	21	.	.	PUNCT
bionys-549	231	22	9	9	NUM
bionys-549	231	23	)	)	PUNCT
bionys-549	231	24	does	do	AUX
bionys-549	231	25	not	not	PART
bionys-549	231	26	extend	extend	VERB
bionys-549	231	27	into	into	ADP
bionys-549	231	28	the	the	DET
bionys-549	231	29	anionic	anionic	ADJ
bionys-549	231	30	binding	bind	VERB
bionys-549	231	31	region	region	NOUN
bionys-549	231	32	or	or	CCONJ
bionys-549	231	33	interfere	interfere	VERB
bionys-549	231	34	with	with	ADP
bionys-549	231	35	the	the	DET
bionys-549	231	36	residues	residue	NOUN
bionys-549	231	37	tyr48	tyr48	VERB
bionys-549	231	38	,	,	PUNCT
bionys-549	231	39	his110	his110	NOUN
bionys-549	231	40	,	,	PUNCT
bionys-549	231	41	and	and	CCONJ
bionys-549	231	42	trp111	trp111	PROPN
bionys-549	231	43	,	,	PUNCT
bionys-549	231	44	which	which	PRON
bionys-549	231	45	are	be	AUX
bionys-549	231	46	responsible	responsible	ADJ
bionys-549	231	47	for	for	ADP
bionys-549	231	48	carrying	carry	VERB
bionys-549	231	49	out	out	ADP
bionys-549	231	50	the	the	DET
bionys-549	231	51	detoxification	detoxification	NOUN
bionys-549	231	52	mechanism	mechanism	NOUN
bionys-549	231	53	of	of	ADP
bionys-549	231	54	toxic	toxic	ADJ
bionys-549	231	55	aldehydes	aldehyde	NOUN
bionys-549	231	56	.	.	PUNCT
bionys-549	232	1	this	this	PRON
bionys-549	232	2	helped	help	VERB
bionys-549	232	3	us	we	PRON
bionys-549	232	4	fulfill	fulfill	VERB
bionys-549	232	5	the	the	DET
bionys-549	232	6	first	first	ADJ
bionys-549	232	7	objective	objective	NOUN
bionys-549	232	8	of	of	ADP
bionys-549	232	9	preventing	prevent	VERB
bionys-549	232	10	glucose	glucose	NOUN
bionys-549	232	11	entry	entry	NOUN
bionys-549	232	12	into	into	ADP
bionys-549	232	13	the	the	DET
bionys-549	232	14	active	active	ADJ
bionys-549	232	15	site	site	NOUN
bionys-549	232	16	.	.	PUNCT
bionys-549	233	1	however	however	ADV
bionys-549	233	2	,	,	PUNCT
bionys-549	233	3	close	close	ADJ
bionys-549	233	4	observations	observation	NOUN
bionys-549	233	5	revealed	reveal	VERB
bionys-549	233	6	that	that	SCONJ
bionys-549	233	7	this	this	DET
bionys-549	233	8	molecule	molecule	NOUN
bionys-549	233	9	has	have	AUX
bionys-549	233	10	bound	bind	VERB
bionys-549	233	11	in	in	ADP
bionys-549	233	12	such	such	DET
bionys-549	233	13	a	a	DET
bionys-549	233	14	spatial	spatial	ADJ
bionys-549	233	15	orientation	orientation	NOUN
bionys-549	233	16	that	that	SCONJ
bionys-549	233	17	it	it	PRON
bionys-549	233	18	may	may	AUX
bionys-549	233	19	or	or	CCONJ
bionys-549	233	20	may	may	AUX
bionys-549	233	21	not	not	PART
bionys-549	233	22	allow	allow	VERB
bionys-549	233	23	the	the	DET
bionys-549	233	24	entry	entry	NOUN
bionys-549	233	25	of	of	ADP
bionys-549	233	26	toxic	toxic	ADJ
bionys-549	233	27	aldehydes	aldehyde	NOUN
bionys-549	233	28	into	into	ADP
bionys-549	233	29	the	the	DET
bionys-549	233	30	pocket	pocket	NOUN
bionys-549	233	31	.	.	PUNCT
bionys-549	234	1	methylglyoxal	methylglyoxal	NOUN
bionys-549	234	2	,	,	PUNCT
bionys-549	234	3	being	be	AUX
bionys-549	234	4	a	a	DET
bionys-549	234	5	four	four	NUM
bionys-549	234	6	-	-	PUNCT
bionys-549	234	7	carbon	carbon	NOUN
bionys-549	234	8	linear	linear	NOUN
bionys-549	234	9	molecule	molecule	NOUN
bionys-549	234	10	,	,	PUNCT
bionys-549	234	11	might	might	AUX
bionys-549	234	12	find	find	VERB
bionys-549	234	13	it	it	PRON
bionys-549	234	14	difficult	difficult	ADJ
bionys-549	234	15	to	to	PART
bionys-549	234	16	enter	enter	VERB
bionys-549	234	17	,	,	PUNCT
bionys-549	234	18	while	while	SCONJ
bionys-549	234	19	glyceraldehyde	glyceraldehyde	NOUN
bionys-549	234	20	may	may	AUX
bionys-549	234	21	be	be	AUX
bionys-549	234	22	allowed	allow	VERB
bionys-549	234	23	to	to	PART
bionys-549	234	24	enter	enter	VERB
bionys-549	234	25	the	the	DET
bionys-549	234	26	pocket	pocket	NOUN
bionys-549	234	27	due	due	ADP
bionys-549	234	28	to	to	ADP
bionys-549	234	29	its	its	PRON
bionys-549	234	30	size	size	NOUN
bionys-549	234	31	and	and	CCONJ
bionys-549	234	32	volume	volume	NOUN
bionys-549	234	33	.	.	PUNCT
bionys-549	235	1	this	this	PRON
bionys-549	235	2	is	be	AUX
bionys-549	235	3	due	due	ADJ
bionys-549	235	4	to	to	ADP
bionys-549	235	5	the	the	DET
bionys-549	235	6	presence	presence	NOUN
bionys-549	235	7	of	of	ADP
bionys-549	235	8	a	a	DET
bionys-549	235	9	sevenmembered	sevenmembere	VERB
bionys-549	235	10	ring	ring	NOUN
bionys-549	235	11	at	at	ADP
bionys-549	235	12	one	one	NUM
bionys-549	235	13	end	end	NOUN
bionys-549	235	14	,	,	PUNCT
bionys-549	235	15	which	which	PRON
bionys-549	235	16	is	be	AUX
bionys-549	235	17	responsible	responsible	ADJ
bionys-549	235	18	for	for	ADP
bionys-549	235	19	this	this	DET
bionys-549	235	20	drawback	drawback	NOUN
bionys-549	235	21	.	.	PUNCT
bionys-549	236	1	the	the	DET
bionys-549	236	2	results	result	NOUN
bionys-549	236	3	of	of	ADP
bionys-549	236	4	the	the	DET
bionys-549	236	5	simulation	simulation	NOUN
bionys-549	236	6	showed	show	VERB
bionys-549	236	7	the	the	DET
bionys-549	236	8	stability	stability	NOUN
bionys-549	236	9	of	of	ADP
bionys-549	236	10	the	the	DET
bionys-549	236	11	complex	complex	NOUN
bionys-549	236	12	from	from	ADP
bionys-549	236	13	25	25	NUM
bionys-549	236	14	ns	ns	NUM
bionys-549	236	15	to	to	ADP
bionys-549	236	16	100	100	NUM
bionys-549	236	17	ns	ns	NUM
bionys-549	236	18	,	,	PUNCT
bionys-549	236	19	indicating	indicate	VERB
bionys-549	236	20	the	the	DET
bionys-549	236	21	intact	intact	ADJ
bionys-549	236	22	nature	nature	NOUN
bionys-549	236	23	of	of	ADP
bionys-549	236	24	the	the	DET
bionys-549	236	25	bound	bind	VERB
bionys-549	236	26	form	form	NOUN
bionys-549	236	27	throughout	throughout	ADP
bionys-549	236	28	the	the	DET
bionys-549	236	29	simulation	simulation	NOUN
bionys-549	236	30	period	period	NOUN
bionys-549	236	31	.	.	PUNCT
bionys-549	237	1	the	the	DET
bionys-549	237	2	structural	structural	ADJ
bionys-549	237	3	stability	stability	NOUN
bionys-549	237	4	of	of	ADP
bionys-549	237	5	the	the	DET
bionys-549	237	6	ligand	ligand	NOUN
bionys-549	237	7	-	-	PUNCT
bionys-549	237	8	bound	bind	VERB
bionys-549	237	9	complex	complex	NOUN
bionys-549	237	10	is	be	AUX
bionys-549	237	11	further	far	ADV
bionys-549	237	12	supported	support	VERB
bionys-549	237	13	by	by	ADP
bionys-549	237	14	rmsf	rmsf	NOUN
bionys-549	237	15	,	,	PUNCT
bionys-549	237	16	wherein	wherein	SCONJ
bionys-549	237	17	the	the	DET
bionys-549	237	18	average	average	ADJ
bionys-549	237	19	fluctuation	fluctuation	NOUN
bionys-549	237	20	rate	rate	NOUN
bionys-549	237	21	is	be	AUX
bionys-549	237	22	0.1	0.1	NUM
bionys-549	237	23	nm	nm	NOUN
bionys-549	237	24	.	.	PUNCT
bionys-549	238	1	however	however	ADV
bionys-549	238	2	,	,	PUNCT
bionys-549	238	3	the	the	DET
bionys-549	238	4	hit	hit	VERB
bionys-549	238	5	molecule	molecule	NOUN
bionys-549	238	6	needs	need	VERB
bionys-549	238	7	to	to	PART
bionys-549	238	8	be	be	AUX
bionys-549	238	9	tested	test	VERB
bionys-549	238	10	to	to	PART
bionys-549	238	11	confirm	confirm	VERB
bionys-549	238	12	the	the	DET
bionys-549	238	13	binding	bind	VERB
bionys-549	238	14	mode	mode	NOUN
bionys-549	238	15	and	and	CCONJ
bionys-549	238	16	its	its	PRON
bionys-549	238	17	potential	potential	ADJ
bionys-549	238	18	use	use	NOUN
bionys-549	238	19	for	for	ADP
bionys-549	238	20	diabetic	diabetic	ADJ
bionys-549	238	21	neuropathy	neuropathy	ADJ
bionys-549	238	22	.	.	PUNCT
bionys-549	239	1	acknowledgements	acknowledgement	NOUN
bionys-549	239	2	.	.	PUNCT
bionys-549	240	1	the	the	DET
bionys-549	240	2	authors	author	NOUN
bionys-549	240	3	thank	thank	VERB
bionys-549	240	4	the	the	DET
bionys-549	240	5	management	management	NOUN
bionys-549	240	6	of	of	ADP
bionys-549	240	7	karpagam	karpagam	PROPN
bionys-549	240	8	charities	charities	PROPN
bionys-549	240	9	trust	trust	PROPN
bionys-549	240	10	,	,	PUNCT
bionys-549	240	11	coimbatore	coimbatore	PROPN
bionys-549	240	12	and	and	CCONJ
bionys-549	240	13	sastra	sastra	PROPN
bionys-549	240	14	university	university	PROPN
bionys-549	240	15	,	,	PUNCT
bionys-549	240	16	thanjavur	thanjavur	NOUN
bionys-549	240	17	for	for	ADP
bionys-549	240	18	their	their	PRON
bionys-549	240	19	support	support	NOUN
bionys-549	240	20	throughout	throughout	ADP
bionys-549	240	21	all	all	DET
bionys-549	240	22	aspects	aspect	NOUN
bionys-549	240	23	of	of	ADP
bionys-549	240	24	our	our	PRON
bionys-549	240	25	study	study	NOUN
bionys-549	240	26	.	.	PUNCT
bionys-549	241	1	references	reference	NOUN
bionys-549	241	2	bakal	bakal	PROPN
bionys-549	241	3	,	,	PUNCT
bionys-549	241	4	r.l	r.l	PROPN
bionys-549	241	5	.	.	PROPN
bionys-549	241	6	,	,	PUNCT
bionys-549	241	7	jawarkar	jawarkar	PROPN
bionys-549	241	8	,	,	PUNCT
bionys-549	241	9	r.d	r.d	PROPN
bionys-549	241	10	.	.	PROPN
bionys-549	241	11	,	,	PUNCT
bionys-549	241	12	manwar	manwar	PROPN
bionys-549	241	13	,	,	PUNCT
bionys-549	241	14	j.v	j.v	PROPN
bionys-549	241	15	.	.	PROPN
bionys-549	241	16	,	,	PUNCT
bionys-549	241	17	jaiswal	jaiswal	PROPN
bionys-549	241	18	,	,	PUNCT
bionys-549	241	19	m.s	m.s	PROPN
bionys-549	241	20	.	.	PROPN
bionys-549	241	21	,	,	PUNCT
bionys-549	241	22	ghosh	ghosh	PROPN
bionys-549	241	23	,	,	PUNCT
bionys-549	241	24	a.	a.	PROPN
bionys-549	241	25	,	,	PUNCT
bionys-549	241	26	gandhi	gandhi	PROPN
bionys-549	241	27	,	,	PUNCT
bionys-549	241	28	a.	a.	PROPN
bionys-549	241	29	,	,	PUNCT
bionys-549	241	30	zaki	zaki	PROPN
bionys-549	241	31	,	,	PUNCT
bionys-549	241	32	m.e	m.e	PROPN
bionys-549	241	33	.	.	PROPN
bionys-549	241	34	,	,	PUNCT
bionys-549	241	35	al	al	PROPN
bionys-549	241	36	-	-	PUNCT
bionys-549	241	37	hussain	hussain	PROPN
bionys-549	241	38	,	,	PUNCT
bionys-549	241	39	s.	s.	PROPN
bionys-549	241	40	,	,	PUNCT
bionys-549	241	41	samad	samad	PROPN
bionys-549	241	42	,	,	PUNCT
bionys-549	241	43	a.	a.	NOUN
bionys-549	241	44	,	,	PUNCT
bionys-549	241	45	masand	masand	PROPN
bionys-549	241	46	,	,	PUNCT
bionys-549	241	47	v.h	v.h	PROPN
bionys-549	241	48	.	.	PROPN
bionys-549	241	49	,	,	PUNCT
bionys-549	241	50	&	&	CCONJ
bionys-549	241	51	mukerjee	mukerjee	PROPN
bionys-549	241	52	,	,	PUNCT
bionys-549	241	53	n.	n.	NOUN
bionys-549	241	54	(	(	PUNCT
bionys-549	241	55	2022	2022	NUM
bionys-549	241	56	)	)	PUNCT
bionys-549	241	57	.	.	PUNCT
bionys-549	242	1	identification	identification	NOUN
bionys-549	242	2	of	of	ADP
bionys-549	242	3	potent	potent	ADJ
bionys-549	242	4	aldose	aldose	ADJ
bionys-549	242	5	reductase	reductase	NOUN
bionys-549	242	6	inhibitors	inhibitor	NOUN
bionys-549	242	7	as	as	ADP
bionys-549	242	8	antidiabetic	antidiabetic	ADJ
bionys-549	242	9	(	(	PUNCT
bionys-549	242	10	antihyperglycemic	antihyperglycemic	ADJ
bionys-549	242	11	)	)	PUNCT
bionys-549	242	12	agents	agent	NOUN
bionys-549	242	13	using	use	VERB
bionys-549	242	14	qsar	qsar	NOUN
bionys-549	242	15	based	base	VERB
bionys-549	242	16	virtual	virtual	ADJ
bionys-549	242	17	screening	screening	NOUN
bionys-549	242	18	,	,	PUNCT
bionys-549	242	19	molecular	molecular	ADJ
bionys-549	242	20	docking	docking	NOUN
bionys-549	242	21	,	,	PUNCT
bionys-549	242	22	md	md	PROPN
bionys-549	242	23	simulation	simulation	NOUN
bionys-549	242	24	and	and	CCONJ
bionys-549	242	25	mmgbsa	mmgbsa	NOUN
bionys-549	242	26	approaches	approach	NOUN
bionys-549	242	27	.	.	PUNCT
bionys-549	243	1	saudi	saudi	ADJ
bionys-549	243	2	pharmaceutical	pharmaceutical	PROPN
bionys-549	243	3	journal	journal	NOUN
bionys-549	243	4	,	,	PUNCT
bionys-549	243	5	30(6	30(6	NUM
bionys-549	243	6	)	)	PUNCT
bionys-549	243	7	,	,	PUNCT
bionys-549	243	8	693	693	NUM
bionys-549	243	9	-	-	SYM
bionys-549	243	10	710	710	NUM
bionys-549	243	11	.	.	PUNCT
bionys-549	244	1	balestri	balestri	PROPN
bionys-549	244	2	,	,	PUNCT
bionys-549	244	3	f.	f.	PROPN
bionys-549	244	4	,	,	PUNCT
bionys-549	244	5	moschini	moschini	PROPN
bionys-549	244	6	,	,	PUNCT
bionys-549	244	7	r.	r.	PROPN
bionys-549	244	8	,	,	PUNCT
bionys-549	244	9	mura	mura	PROPN
bionys-549	244	10	,	,	PUNCT
bionys-549	244	11	u.	u.	PROPN
bionys-549	244	12	,	,	PUNCT
bionys-549	244	13	cappiello	cappiello	PROPN
bionys-549	244	14	,	,	PUNCT
bionys-549	244	15	m.	m.	NOUN
bionys-549	244	16	&	&	CCONJ
bionys-549	244	17	del	del	PROPN
bionys-549	244	18	corso	corso	PROPN
bionys-549	244	19	,	,	PUNCT
bionys-549	244	20	a.	a.	NOUN
bionys-549	244	21	(	(	PUNCT
bionys-549	244	22	2022	2022	NUM
bionys-549	244	23	)	)	PUNCT
bionys-549	244	24	.	.	PUNCT
bionys-549	245	1	in	in	ADP
bionys-549	245	2	search	search	NOUN
bionys-549	245	3	of	of	ADP
bionys-549	245	4	differential	differential	ADJ
bionys-549	245	5	inhibitors	inhibitor	NOUN
bionys-549	245	6	of	of	ADP
bionys-549	245	7	aldose	aldose	DET
bionys-549	245	8	reductase	reductase	NOUN
bionys-549	245	9	.	.	PUNCT
bionys-549	245	10	biomolecules	biomolecule	NOUN
bionys-549	245	11	,	,	PUNCT
bionys-549	245	12	12(4	12(4	NUM
bionys-549	245	13	)	)	PUNCT
bionys-549	245	14	,	,	PUNCT
bionys-549	245	15	485	485	NUM
bionys-549	245	16	.	.	PUNCT
bionys-549	246	1	chaudhry	chaudhry	PROPN
bionys-549	246	2	,	,	PUNCT
bionys-549	246	3	p.s	p.s	PROPN
bionys-549	246	4	.	.	PROPN
bionys-549	246	5	,	,	PUNCT
bionys-549	246	6	cabrera	cabrera	PROPN
bionys-549	246	7	,	,	PUNCT
bionys-549	246	8	j.	j.	PROPN
bionys-549	246	9	,	,	PUNCT
bionys-549	246	10	juliani	juliani	PROPN
bionys-549	246	11	,	,	PUNCT
bionys-549	246	12	h.r	h.r	PROPN
bionys-549	246	13	.	.	PROPN
bionys-549	246	14	,	,	PUNCT
bionys-549	246	15	&	&	CCONJ
bionys-549	246	16	varma	varma	PROPN
bionys-549	246	17	,	,	PUNCT
bionys-549	246	18	s.d	s.d	PROPN
bionys-549	246	19	.	.	PROPN
bionys-549	246	20	(	(	PUNCT
bionys-549	246	21	1983	1983	NUM
bionys-549	246	22	)	)	PUNCT
bionys-549	246	23	.	.	PUNCT
bionys-549	247	1	inhibition	inhibition	NOUN
bionys-549	247	2	of	of	ADP
bionys-549	247	3	human	human	ADJ
bionys-549	247	4	lens	lens	NOUN
bionys-549	247	5	aldose	aldose	PROPN
bionys-549	247	6	reductase	reductase	NOUN
bionys-549	247	7	by	by	ADP
bionys-549	247	8	flavonoids	flavonoid	NOUN
bionys-549	247	9	,	,	PUNCT
bionys-549	247	10	sulindac	sulindac	NOUN
bionys-549	247	11	and	and	CCONJ
bionys-549	247	12	indomethacin	indomethacin	NOUN
bionys-549	247	13	.	.	PUNCT
bionys-549	248	1	biochemical	biochemical	ADJ
bionys-549	248	2	pharmacology	pharmacology	NOUN
bionys-549	248	3	,	,	PUNCT
bionys-549	248	4	32(13	32(13	NUM
bionys-549	248	5	)	)	PUNCT
bionys-549	248	6	,	,	PUNCT
bionys-549	248	7	1995	1995	NUM
bionys-549	248	8	-	-	SYM
bionys-549	248	9	1998	1998	NUM
bionys-549	248	10	.	.	PUNCT
bionys-549	249	1	chen	chen	PROPN
bionys-549	249	2	,	,	PUNCT
bionys-549	249	3	c.y	c.y	PROPN
bionys-549	249	4	.	.	PROPN
bionys-549	249	5	,	,	PUNCT
bionys-549	249	6	zhang	zhang	PROPN
bionys-549	249	7	,	,	PUNCT
bionys-549	249	8	j.q	j.q	PROPN
bionys-549	249	9	.	.	PROPN
bionys-549	249	10	,	,	PUNCT
bionys-549	249	11	li	li	PROPN
bionys-549	249	12	,	,	PUNCT
bionys-549	249	13	l.	l.	PROPN
bionys-549	249	14	,	,	PUNCT
bionys-549	249	15	guo	guo	PROPN
bionys-549	249	16	,	,	PUNCT
bionys-549	249	17	m.m	m.m	PROPN
bionys-549	249	18	.	.	PROPN
bionys-549	249	19	,	,	PUNCT
bionys-549	249	20	he	he	PRON
bionys-549	249	21	,	,	PUNCT
bionys-549	249	22	y.f	y.f	PROPN
bionys-549	249	23	.	.	PROPN
bionys-549	249	24	,	,	PUNCT
bionys-549	249	25	dong	dong	PROPN
bionys-549	249	26	,	,	PUNCT
bionys-549	249	27	y.m	y.m	PROPN
bionys-549	249	28	.	.	PROPN
bionys-549	249	29	,	,	PUNCT
bionys-549	249	30	meng	meng	PROPN
bionys-549	249	31	,	,	PUNCT
bionys-549	249	32	h.	h.	PROPN
bionys-549	249	33	,	,	PUNCT
bionys-549	249	34	&	&	CCONJ
bionys-549	249	35	yi	yi	PROPN
bionys-549	249	36	,	,	PUNCT
bionys-549	249	37	f.	f.	PROPN
bionys-549	249	38	(	(	PUNCT
bionys-549	249	39	2022	2022	NUM
bionys-549	249	40	)	)	PUNCT
bionys-549	249	41	.	.	PUNCT
bionys-549	250	1	advanced	advanced	ADJ
bionys-549	250	2	glycation	glycation	NOUN
bionys-549	250	3	end	end	NOUN
bionys-549	250	4	products	product	NOUN
bionys-549	250	5	in	in	ADP
bionys-549	250	6	the	the	DET
bionys-549	250	7	skin	skin	NOUN
bionys-549	250	8	:	:	PUNCT
bionys-549	250	9	molecular	molecular	ADJ
bionys-549	250	10	mechanisms	mechanism	NOUN
bionys-549	250	11	,	,	PUNCT
bionys-549	250	12	methods	method	NOUN
bionys-549	250	13	of	of	ADP
bionys-549	250	14	measurement	measurement	NOUN
bionys-549	250	15	,	,	PUNCT
bionys-549	250	16	and	and	CCONJ
bionys-549	250	17	inhibitory	inhibitory	ADJ
bionys-549	250	18	pathways	pathway	NOUN
bionys-549	250	19	.	.	PUNCT
bionys-549	251	1	frontiers	frontier	NOUN
bionys-549	251	2	in	in	ADP
bionys-549	251	3	medicine	medicine	NOUN
bionys-549	251	4	,	,	PUNCT
bionys-549	251	5	9	9	NUM
bionys-549	251	6	,	,	PUNCT
bionys-549	251	7	837222	837222	NUM
bionys-549	251	8	.	.	PUNCT
bionys-549	252	1	ciccone	ciccone	PROPN
bionys-549	252	2	,	,	PUNCT
bionys-549	252	3	l.	l.	PROPN
bionys-549	252	4	,	,	PUNCT
bionys-549	252	5	petrarolo	petrarolo	PROPN
bionys-549	252	6	,	,	PUNCT
bionys-549	252	7	g.	g.	PROPN
bionys-549	252	8	,	,	PUNCT
bionys-549	252	9	barsuglia	barsuglia	PROPN
bionys-549	252	10	,	,	PUNCT
bionys-549	252	11	f.	f.	PROPN
bionys-549	252	12	,	,	PUNCT
bionys-549	252	13	fruchartgaillard	fruchartgaillard	PROPN
bionys-549	252	14	,	,	PUNCT
bionys-549	252	15	c.	c.	PROPN
bionys-549	252	16	,	,	PUNCT
bionys-549	252	17	cassar	cassar	PROPN
bionys-549	252	18	lajeunesse	lajeunesse	PROPN
bionys-549	252	19	,	,	PUNCT
bionys-549	252	20	e.	e.	PROPN
bionys-549	252	21	,	,	PUNCT
bionys-549	252	22	adewumi	adewumi	PROPN
bionys-549	252	23	,	,	PUNCT
bionys-549	252	24	a.t	a.t	PROPN
bionys-549	252	25	.	.	PROPN
bionys-549	252	26	,	,	PUNCT
bionys-549	252	27	soliman	soliman	PROPN
bionys-549	252	28	,	,	PUNCT
bionys-549	252	29	m.e	m.e	PROPN
bionys-549	252	30	.	.	PROPN
bionys-549	252	31	,	,	PUNCT
bionys-549	252	32	la	la	PROPN
bionys-549	252	33	motta	motta	PROPN
bionys-549	252	34	,	,	PUNCT
bionys-549	252	35	c.	c.	PROPN
bionys-549	252	36	,	,	PUNCT
bionys-549	252	37	orlandini	orlandini	PROPN
bionys-549	252	38	,	,	PUNCT
bionys-549	252	39	e.	e.	PROPN
bionys-549	252	40	,	,	PUNCT
bionys-549	252	41	&	&	CCONJ
bionys-549	252	42	nencetti	nencetti	PROPN
bionys-549	252	43	,	,	PUNCT
bionys-549	252	44	s.	s.	PROPN
bionys-549	252	45	(	(	PUNCT
bionys-549	252	46	2022	2022	NUM
bionys-549	252	47	)	)	PUNCT
bionys-549	252	48	.	.	PUNCT
bionys-549	253	1	nature	nature	NOUN
bionys-549	253	2	-	-	PUNCT
bionys-549	253	3	inspired	inspire	VERB
bionys-549	253	4	o	o	ADJ
bionys-549	253	5	-	-	ADJ
bionys-549	253	6	benzyl	benzyl	ADJ
bionys-549	253	7	oxime	oxime	NOUN
bionys-549	253	8	-	-	PUNCT
bionys-549	253	9	based	base	VERB
bionys-549	253	10	derivatives	derivative	NOUN
bionys-549	253	11	as	as	ADP
bionys-549	253	12	new	new	ADJ
bionys-549	253	13	dual	dual	ADV
bionys-549	253	14	-	-	PUNCT
bionys-549	253	15	acting	act	VERB
bionys-549	253	16	agents	agent	NOUN
bionys-549	253	17	targeting	target	VERB
bionys-549	253	18	aldose	aldose	ADJ
bionys-549	253	19	reductase	reductase	NOUN
bionys-549	253	20	and	and	CCONJ
bionys-549	253	21	oxidative	oxidative	ADJ
bionys-549	253	22	stress	stress	NOUN
bionys-549	253	23	.	.	PUNCT
bionys-549	254	1	biomolecules	biomolecule	NOUN
bionys-549	254	2	,	,	PUNCT
bionys-549	254	3	12(3	12(3	NUM
bionys-549	254	4	)	)	PUNCT
bionys-549	254	5	,	,	PUNCT
bionys-549	254	6	448	448	NUM
bionys-549	254	7	.	.	PUNCT
bionys-549	254	8	friesner	friesner	NOUN
bionys-549	254	9	,	,	PUNCT
bionys-549	254	10	r.a	r.a	PROPN
bionys-549	254	11	.	.	PROPN
bionys-549	254	12	,	,	PUNCT
bionys-549	254	13	murphy	murphy	PROPN
bionys-549	254	14	,	,	PUNCT
bionys-549	254	15	r.b	r.b	PROPN
bionys-549	254	16	.	.	PROPN
bionys-549	254	17	,	,	PUNCT
bionys-549	254	18	repasky	repasky	ADJ
bionys-549	254	19	,	,	PUNCT
bionys-549	254	20	m.p	m.p	PROPN
bionys-549	254	21	.	.	PROPN
bionys-549	254	22	,	,	PUNCT
bionys-549	254	23	frye	frye	PROPN
bionys-549	254	24	,	,	PUNCT
bionys-549	254	25	l.l	l.l	PROPN
bionys-549	254	26	.	.	PROPN
bionys-549	254	27	,	,	PUNCT
bionys-549	254	28	greenwood	greenwood	PROPN
bionys-549	254	29	,	,	PUNCT
bionys-549	254	30	j.r	j.r	PROPN
bionys-549	254	31	.	.	PROPN
bionys-549	254	32	,	,	PUNCT
bionys-549	254	33	halgren	halgren	PROPN
bionys-549	254	34	,	,	PUNCT
bionys-549	254	35	t.a	t.a	PROPN
bionys-549	254	36	.	.	PROPN
bionys-549	254	37	,	,	PUNCT
bionys-549	254	38	sanschagrin	sanschagrin	PROPN
bionys-549	254	39	,	,	PUNCT
bionys-549	254	40	p.c	p.c	PROPN
bionys-549	254	41	.	.	PROPN
bionys-549	254	42	,	,	PUNCT
bionys-549	254	43	&	&	CCONJ
bionys-549	254	44	mainz	mainz	PROPN
bionys-549	254	45	,	,	PUNCT
bionys-549	254	46	d.t	d.t	PROPN
bionys-549	254	47	.	.	PUNCT
bionys-549	254	48	(	(	PUNCT
bionys-549	254	49	2006	2006	NUM
bionys-549	254	50	)	)	PUNCT
bionys-549	254	51	.	.	PUNCT
bionys-549	255	1	extra	extra	ADJ
bionys-549	255	2	precision	precision	NOUN
bionys-549	255	3	glide	glide	NOUN
bionys-549	255	4	:	:	PUNCT
bionys-549	255	5	docking	docking	NOUN
bionys-549	255	6	and	and	CCONJ
bionys-549	255	7	scoring	scoring	NOUN
bionys-549	255	8	incorporating	incorporate	VERB
bionys-549	255	9	a	a	DET
bionys-549	255	10	model	model	NOUN
bionys-549	255	11	of	of	ADP
bionys-549	255	12	hydrophobic	hydrophobic	NOUN
bionys-549	255	13	enclosure	enclosure	NOUN
bionys-549	255	14	for	for	ADP
bionys-549	255	15	protein−	protein−	NOUN
bionys-549	255	16	ligand	ligand	NOUN
bionys-549	255	17	complexes	complex	NOUN
bionys-549	255	18	.	.	PUNCT
bionys-549	256	1	journal	journal	NOUN
bionys-549	256	2	of	of	ADP
bionys-549	256	3	medicinal	medicinal	ADJ
bionys-549	256	4	chemistry	chemistry	NOUN
bionys-549	256	5	,	,	PUNCT
bionys-549	256	6	49(21	49(21	NUM
bionys-549	256	7	)	)	PUNCT
bionys-549	256	8	,	,	PUNCT
bionys-549	256	9	6177	6177	NUM
bionys-549	256	10	-	-	SYM
bionys-549	256	11	6196	6196	NUM
bionys-549	256	12	.	.	PUNCT
bionys-549	257	1	goto	goto	NOUN
bionys-549	257	2	,	,	PUNCT
bionys-549	257	3	y.	y.	PROPN
bionys-549	257	4	,	,	PUNCT
bionys-549	257	5	hotta	hotta	ADJ
bionys-549	257	6	,	,	PUNCT
bionys-549	257	7	n.	n.	NOUN
bionys-549	257	8	,	,	PUNCT
bionys-549	257	9	shigeta	shigeta	ADJ
bionys-549	257	10	,	,	PUNCT
bionys-549	257	11	y.	y.	PROPN
bionys-549	257	12	,	,	PUNCT
bionys-549	257	13	sakamoto	sakamoto	PROPN
bionys-549	257	14	,	,	PUNCT
bionys-549	257	15	n.	n.	PROPN
bionys-549	257	16	and	and	CCONJ
bionys-549	257	17	kikkawa	kikkawa	PROPN
bionys-549	257	18	,	,	PUNCT
bionys-549	257	19	r.	r.	PROPN
bionys-549	257	20	(	(	PUNCT
bionys-549	257	21	1995	1995	NUM
bionys-549	257	22	)	)	PUNCT
bionys-549	257	23	.	.	PUNCT
bionys-549	258	1	effects	effect	NOUN
bionys-549	258	2	of	of	ADP
bionys-549	258	3	an	an	DET
bionys-549	258	4	aldose	aldose	ADJ
bionys-549	258	5	reductase	reductase	NOUN
bionys-549	258	6	inhibitor	inhibitor	NOUN
bionys-549	258	7	,	,	PUNCT
bionys-549	258	8	epalrestat	epalrestat	NOUN
bionys-549	258	9	,	,	PUNCT
bionys-549	258	10	on	on	ADP
bionys-549	258	11	diabetic	diabetic	ADJ
bionys-549	258	12	neuropathy	neuropathy	ADJ
bionys-549	258	13	.	.	PUNCT
bionys-549	259	1	clinical	clinical	ADJ
bionys-549	259	2	benefit	benefit	NOUN
bionys-549	259	3	and	and	CCONJ
bionys-549	259	4	indication	indication	NOUN
bionys-549	259	5	for	for	ADP
bionys-549	259	6	the	the	DET
bionys-549	259	7	drug	drug	NOUN
bionys-549	259	8	assessed	assess	VERB
bionys-549	259	9	from	from	ADP
bionys-549	259	10	the	the	DET
bionys-549	259	11	results	result	NOUN
bionys-549	259	12	of	of	ADP
bionys-549	259	13	a	a	DET
bionys-549	259	14	placebo	placebo	NOUN
bionys-549	259	15	-	-	PUNCT
bionys-549	259	16	controlled	control	VERB
bionys-549	259	17	double	double	ADJ
bionys-549	259	18	-	-	PUNCT
bionys-549	259	19	blind	blind	ADJ
bionys-549	259	20	study	study	NOUN
bionys-549	259	21	.	.	PUNCT
bionys-549	260	1	biomedicine	biomedicine	NOUN
bionys-549	260	2	&	&	CCONJ
bionys-549	260	3	pharmacotherapy	pharmacotherapy	NOUN
bionys-549	260	4	,	,	PUNCT
bionys-549	260	5	49(6	49(6	NOUN
bionys-549	260	6	)	)	PUNCT
bionys-549	260	7	,	,	PUNCT
bionys-549	260	8	269	269	NUM
bionys-549	260	9	-	-	SYM
bionys-549	260	10	277	277	NUM
bionys-549	260	11	.	.	PUNCT
bionys-549	261	1	gronda	gronda	NOUN
bionys-549	261	2	,	,	PUNCT
bionys-549	261	3	e.	e.	PROPN
bionys-549	261	4	,	,	PUNCT
bionys-549	261	5	jessup	jessup	PROPN
bionys-549	261	6	,	,	PUNCT
bionys-549	261	7	m.	m.	NOUN
bionys-549	261	8	,	,	PUNCT
bionys-549	261	9	iacoviello	iacoviello	PROPN
bionys-549	261	10	,	,	PUNCT
bionys-549	261	11	m.	m.	NOUN
bionys-549	261	12	,	,	PUNCT
bionys-549	261	13	palazzuoli	palazzuoli	NOUN
bionys-549	261	14	,	,	PUNCT
bionys-549	261	15	a.	a.	NOUN
bionys-549	261	16	,	,	PUNCT
bionys-549	261	17	&	&	CCONJ
bionys-549	261	18	napoli	napoli	PROPN
bionys-549	261	19	,	,	PUNCT
bionys-549	261	20	c.	c.	PROPN
bionys-549	261	21	(	(	PUNCT
bionys-549	261	22	2020	2020	NUM
bionys-549	261	23	)	)	PUNCT
bionys-549	261	24	.	.	PUNCT
bionys-549	262	1	glucose	glucose	NOUN
bionys-549	262	2	metabolism	metabolism	NOUN
bionys-549	262	3	in	in	ADP
bionys-549	262	4	the	the	DET
bionys-549	262	5	kidney	kidney	NOUN
bionys-549	262	6	:	:	PUNCT
bionys-549	262	7	neurohormonal	neurohormonal	ADJ
bionys-549	262	8	activation	activation	NOUN
bionys-549	262	9	and	and	CCONJ
bionys-549	262	10	heart	heart	NOUN
bionys-549	262	11	failure	failure	NOUN
bionys-549	262	12	development	development	NOUN
bionys-549	262	13	.	.	PUNCT
bionys-549	263	1	journal	journal	NOUN
bionys-549	263	2	of	of	ADP
bionys-549	263	3	the	the	DET
bionys-549	263	4	american	american	PROPN
bionys-549	263	5	heart	heart	PROPN
bionys-549	263	6	association	association	PROPN
bionys-549	263	7	,	,	PUNCT
bionys-549	263	8	9(23	9(23	NOUN
bionys-549	263	9	)	)	PUNCT
bionys-549	263	10	,	,	PUNCT
bionys-549	263	11	e018889	e018889	PROPN
bionys-549	263	12	.	.	PROPN
bionys-549	263	13	132	132	NUM
bionys-549	263	14	biologica	biologica	PROPN
bionys-549	263	15	nyssana	nyssana	PROPN
bionys-549	264	1	●	●	PUNCT
bionys-549	264	2	15	15	NUM
bionys-549	264	3	(	(	PUNCT
bionys-549	264	4	2	2	NUM
bionys-549	264	5	)	)	PUNCT
bionys-549	264	6	december	december	PROPN
bionys-549	264	7	2024	2024	NUM
bionys-549	264	8	:	:	PUNCT
bionys-549	264	9	nagarajan	nagarajan	NOUN
bionys-549	264	10	et	et	PROPN
bionys-549	264	11	al	al	PROPN
bionys-549	264	12	.	.	PUNCT
bionys-549	265	1	●	●	PUNCT
bionys-549	265	2	beyond	beyond	ADP
bionys-549	265	3	boundaries	boundary	NOUN
bionys-549	265	4	:	:	PUNCT
bionys-549	265	5	pioneering	pioneer	VERB
bionys-549	265	6	discoveries	discovery	NOUN
bionys-549	265	7	in	in	ADP
bionys-549	265	8	aldose	aldose	PRON
bionys-549	265	9	reductase	reductase	NOUN
bionys-549	265	10	inhibition	inhibition	NOUN
bionys-549	265	11	for	for	ADP
bionys-549	265	12	diabetic	diabetic	ADJ
bionys-549	265	13	neuropathy	neuropathy	ADJ
bionys-549	265	14	imran	imran	PROPN
bionys-549	265	15	,	,	PUNCT
bionys-549	265	16	a.	a.	PROPN
bionys-549	265	17	,	,	PUNCT
bionys-549	265	18	shehzad	shehzad	PROPN
bionys-549	265	19	,	,	PUNCT
bionys-549	265	20	m.t	m.t	PROPN
bionys-549	265	21	.	.	PROPN
bionys-549	265	22	,	,	PUNCT
bionys-549	265	23	shah	shah	PROPN
bionys-549	265	24	,	,	PUNCT
bionys-549	265	25	s.j.a	s.j.a	PROPN
bionys-549	265	26	.	.	PROPN
bionys-549	265	27	,	,	PUNCT
bionys-549	265	28	al	al	PROPN
bionys-549	265	29	adhami	adhami	PROPN
bionys-549	265	30	,	,	PUNCT
bionys-549	265	31	t.	t.	NOUN
bionys-549	265	32	,	,	PUNCT
bionys-549	265	33	laws	law	NOUN
bionys-549	265	34	,	,	PUNCT
bionys-549	265	35	m.	m.	NOUN
bionys-549	265	36	,	,	PUNCT
bionys-549	265	37	rahman	rahman	PROPN
bionys-549	265	38	,	,	PUNCT
bionys-549	265	39	k.m	k.m	PROPN
bionys-549	265	40	.	.	PROPN
bionys-549	265	41	,	,	PUNCT
bionys-549	265	42	alharthy	alharthy	PROPN
bionys-549	265	43	,	,	PUNCT
bionys-549	265	44	r.d	r.d	PROPN
bionys-549	265	45	.	.	PROPN
bionys-549	265	46	,	,	PUNCT
bionys-549	265	47	khan	khan	PROPN
bionys-549	265	48	,	,	PUNCT
bionys-549	265	49	i.a	i.a	PROPN
bionys-549	265	50	.	.	PROPN
bionys-549	265	51	,	,	PUNCT
bionys-549	265	52	shafiq	shafiq	PROPN
bionys-549	265	53	,	,	PUNCT
bionys-549	265	54	z.	z.	PROPN
bionys-549	265	55	,	,	PUNCT
bionys-549	265	56	&	&	CCONJ
bionys-549	265	57	iqbal	iqbal	PROPN
bionys-549	265	58	,	,	PUNCT
bionys-549	265	59	j.	j.	PROPN
bionys-549	265	60	(	(	PUNCT
bionys-549	265	61	2022	2022	NUM
bionys-549	265	62	)	)	PUNCT
bionys-549	265	63	.	.	PUNCT
bionys-549	266	1	development	development	NOUN
bionys-549	266	2	and	and	CCONJ
bionys-549	266	3	exploration	exploration	NOUN
bionys-549	266	4	of	of	ADP
bionys-549	266	5	novel	novel	ADJ
bionys-549	266	6	substituted	substitute	VERB
bionys-549	266	7	thiosemicarbazones	thiosemicarbazone	NOUN
bionys-549	266	8	as	as	ADP
bionys-549	266	9	inhibitors	inhibitor	NOUN
bionys-549	266	10	of	of	ADP
bionys-549	266	11	aldose	aldose	DET
bionys-549	266	12	reductase	reductase	NOUN
bionys-549	266	13	via	via	ADP
bionys-549	266	14	in	in	ADP
bionys-549	266	15	vitro	vitro	X
bionys-549	266	16	analysis	analysis	NOUN
bionys-549	266	17	and	and	CCONJ
bionys-549	266	18	computational	computational	ADJ
bionys-549	266	19	study	study	NOUN
bionys-549	266	20	.	.	PUNCT
bionys-549	267	1	scientific	scientific	ADJ
bionys-549	267	2	reports	report	NOUN
bionys-549	267	3	,	,	PUNCT
bionys-549	267	4	12(1	12(1	NUM
bionys-549	267	5	)	)	PUNCT
bionys-549	267	6	,	,	PUNCT
bionys-549	267	7	5734	5734	NUM
bionys-549	267	8	.	.	PUNCT
bionys-549	268	1	jensen	jensen	PROPN
bionys-549	268	2	,	,	PUNCT
bionys-549	268	3	t.s	t.s	PROPN
bionys-549	268	4	.	.	PROPN
bionys-549	268	5	,	,	PUNCT
bionys-549	268	6	karlsson	karlsson	PROPN
bionys-549	268	7	,	,	PUNCT
bionys-549	268	8	p.	p.	PROPN
bionys-549	268	9	,	,	PUNCT
bionys-549	268	10	gylfadottir	gylfadottir	PROPN
bionys-549	268	11	,	,	PUNCT
bionys-549	268	12	s.s	s.s	PROPN
bionys-549	268	13	.	.	PROPN
bionys-549	268	14	,	,	PUNCT
bionys-549	268	15	andersen	andersen	PROPN
bionys-549	268	16	,	,	PUNCT
bionys-549	268	17	s.t	s.t	PROPN
bionys-549	268	18	.	.	PROPN
bionys-549	268	19	,	,	PUNCT
bionys-549	268	20	bennett	bennett	PROPN
bionys-549	268	21	,	,	PUNCT
bionys-549	268	22	d.l	d.l	PROPN
bionys-549	268	23	.	.	PROPN
bionys-549	268	24	,	,	PUNCT
bionys-549	268	25	tankisi	tankisi	PROPN
bionys-549	268	26	,	,	PUNCT
bionys-549	268	27	h.	h.	NOUN
bionys-549	268	28	,	,	PUNCT
bionys-549	268	29	finnerup	finnerup	NOUN
bionys-549	268	30	,	,	PUNCT
bionys-549	268	31	n.b	n.b	PROPN
bionys-549	268	32	.	.	PROPN
bionys-549	268	33	,	,	PUNCT
bionys-549	268	34	terkelsen	terkelsen	PROPN
bionys-549	268	35	,	,	PUNCT
bionys-549	268	36	a.j	a.j	PROPN
bionys-549	268	37	.	.	PROPN
bionys-549	268	38	,	,	PUNCT
bionys-549	268	39	khan	khan	PROPN
bionys-549	268	40	,	,	PUNCT
bionys-549	268	41	k.	k.	PROPN
bionys-549	268	42	,	,	PUNCT
bionys-549	268	43	themistocleous	themistocleous	ADJ
bionys-549	268	44	,	,	PUNCT
bionys-549	268	45	a.c	a.c	PROPN
bionys-549	268	46	.	.	PROPN
bionys-549	268	47	,	,	PUNCT
bionys-549	268	48	&	&	CCONJ
bionys-549	268	49	kristensen	kristensen	PROPN
bionys-549	268	50	,	,	PUNCT
bionys-549	268	51	a.g	a.g	PROPN
bionys-549	268	52	.	.	PROPN
bionys-549	268	53	(	(	PUNCT
bionys-549	268	54	2021	2021	NUM
bionys-549	268	55	)	)	PUNCT
bionys-549	268	56	.	.	PUNCT
bionys-549	269	1	painful	painful	ADJ
bionys-549	269	2	and	and	CCONJ
bionys-549	269	3	non	non	ADJ
bionys-549	269	4	-	-	ADJ
bionys-549	269	5	painful	painful	ADJ
bionys-549	269	6	diabetic	diabetic	ADJ
bionys-549	269	7	neuropathy	neuropathy	ADJ
bionys-549	269	8	,	,	PUNCT
bionys-549	269	9	diagnostic	diagnostic	ADJ
bionys-549	269	10	challenges	challenge	NOUN
bionys-549	269	11	and	and	CCONJ
bionys-549	269	12	implications	implication	NOUN
bionys-549	269	13	for	for	ADP
bionys-549	269	14	future	future	ADJ
bionys-549	269	15	management	management	NOUN
bionys-549	269	16	.	.	PUNCT
bionys-549	270	1	brain	brain	NOUN
bionys-549	270	2	,	,	PUNCT
bionys-549	270	3	144(6	144(6	NUM
bionys-549	270	4	)	)	PUNCT
bionys-549	270	5	,	,	PUNCT
bionys-549	270	6	1632	1632	NUM
bionys-549	270	7	-	-	SYM
bionys-549	270	8	1645	1645	NUM
bionys-549	270	9	.	.	PUNCT
bionys-549	271	1	klebe	klebe	PROPN
bionys-549	271	2	,	,	PUNCT
bionys-549	271	3	g.	g.	PROPN
bionys-549	271	4	,	,	PUNCT
bionys-549	271	5	krämer	krämer	NOUN
bionys-549	271	6	,	,	PUNCT
bionys-549	271	7	o.	o.	PROPN
bionys-549	271	8	,	,	PUNCT
bionys-549	271	9	&	&	CCONJ
bionys-549	271	10	sotriffer	sotriffer	PROPN
bionys-549	271	11	,	,	PUNCT
bionys-549	271	12	c.	c.	PROPN
bionys-549	271	13	(	(	PUNCT
bionys-549	271	14	2004	2004	NUM
bionys-549	271	15	)	)	PUNCT
bionys-549	271	16	.	.	PUNCT
bionys-549	272	1	strategies	strategy	NOUN
bionys-549	272	2	for	for	ADP
bionys-549	272	3	the	the	DET
bionys-549	272	4	design	design	NOUN
bionys-549	272	5	of	of	ADP
bionys-549	272	6	inhibitors	inhibitor	NOUN
bionys-549	272	7	of	of	ADP
bionys-549	272	8	aldose	aldose	DET
bionys-549	272	9	reductase	reductase	NOUN
bionys-549	272	10	,	,	PUNCT
bionys-549	272	11	an	an	DET
bionys-549	272	12	enzyme	enzyme	NOUN
bionys-549	272	13	showing	show	VERB
bionys-549	272	14	pronounced	pronounce	VERB
bionys-549	272	15	inducedfit	inducedfit	ADJ
bionys-549	272	16	adaptations	adaptation	NOUN
bionys-549	272	17	.	.	PUNCT
bionys-549	273	1	cellular	cellular	ADJ
bionys-549	273	2	and	and	CCONJ
bionys-549	273	3	molecular	molecular	ADJ
bionys-549	273	4	life	life	NOUN
bionys-549	273	5	sciences	science	NOUN
bionys-549	273	6	cmls	cmls	NOUN
bionys-549	273	7	,	,	PUNCT
bionys-549	273	8	61	61	NUM
bionys-549	273	9	,	,	PUNCT
bionys-549	273	10	783	783	NUM
bionys-549	273	11	-	-	SYM
bionys-549	273	12	793	793	NUM
bionys-549	273	13	.	.	PUNCT
bionys-549	274	1	kondhare	kondhare	PROPN
bionys-549	274	2	,	,	PUNCT
bionys-549	274	3	d.	d.	PROPN
bionys-549	274	4	&	&	CCONJ
bionys-549	274	5	lade	lade	PROPN
bionys-549	274	6	,	,	PUNCT
bionys-549	274	7	h.	h.	PROPN
bionys-549	274	8	(	(	PUNCT
bionys-549	274	9	2017	2017	NUM
bionys-549	274	10	)	)	PUNCT
bionys-549	274	11	.	.	PUNCT
bionys-549	275	1	phytochemical	phytochemical	ADJ
bionys-549	275	2	profile	profile	NOUN
bionys-549	275	3	,	,	PUNCT
bionys-549	275	4	aldose	aldose	ADJ
bionys-549	275	5	reductase	reductase	NOUN
bionys-549	275	6	inhibitory	inhibitory	NOUN
bionys-549	275	7	,	,	PUNCT
bionys-549	275	8	and	and	CCONJ
bionys-549	275	9	antioxidant	antioxidant	ADJ
bionys-549	275	10	activities	activity	NOUN
bionys-549	275	11	of	of	ADP
bionys-549	275	12	indian	indian	ADJ
bionys-549	275	13	traditional	traditional	ADJ
bionys-549	275	14	medicinal	medicinal	ADJ
bionys-549	275	15	coccinia	coccinia	NOUN
bionys-549	275	16	grandis	grandis	NOUN
bionys-549	275	17	(	(	PUNCT
bionys-549	275	18	l.	l.	PROPN
bionys-549	275	19	)	)	PUNCT
bionys-549	275	20	fruit	fruit	NOUN
bionys-549	275	21	extract	extract	NOUN
bionys-549	275	22	.	.	PUNCT
bionys-549	276	1	3	3	NUM
bionys-549	276	2	biotech	biotech	NOUN
bionys-549	276	3	,	,	PUNCT
bionys-549	276	4	7(6	7(6	NUM
bionys-549	276	5	)	)	PUNCT
bionys-549	276	6	,	,	PUNCT
bionys-549	276	7	378	378	NUM
bionys-549	276	8	.	.	PUNCT
bionys-549	277	1	kumar	kumar	PROPN
bionys-549	277	2	,	,	PUNCT
bionys-549	277	3	h.	h.	PROPN
bionys-549	277	4	,	,	PUNCT
bionys-549	277	5	shah	shah	PROPN
bionys-549	277	6	,	,	PUNCT
bionys-549	277	7	a.	a.	PROPN
bionys-549	277	8	,	,	PUNCT
bionys-549	277	9	&	&	CCONJ
bionys-549	277	10	sobhia	sobhia	PROPN
bionys-549	277	11	,	,	PUNCT
bionys-549	277	12	m.e	m.e	PROPN
bionys-549	277	13	.	.	PROPN
bionys-549	277	14	(	(	PUNCT
bionys-549	277	15	2012	2012	NUM
bionys-549	277	16	)	)	PUNCT
bionys-549	277	17	.	.	PUNCT
bionys-549	278	1	novel	novel	ADJ
bionys-549	278	2	insights	insight	NOUN
bionys-549	278	3	into	into	ADP
bionys-549	278	4	the	the	DET
bionys-549	278	5	structural	structural	ADJ
bionys-549	278	6	requirements	requirement	NOUN
bionys-549	278	7	for	for	ADP
bionys-549	278	8	the	the	DET
bionys-549	278	9	design	design	NOUN
bionys-549	278	10	of	of	ADP
bionys-549	278	11	selective	selective	ADJ
bionys-549	278	12	and	and	CCONJ
bionys-549	278	13	specific	specific	ADJ
bionys-549	278	14	aldose	aldose	ADJ
bionys-549	278	15	reductase	reductase	NOUN
bionys-549	278	16	inhibitors	inhibitor	NOUN
bionys-549	278	17	.	.	PUNCT
bionys-549	279	1	journal	journal	NOUN
bionys-549	279	2	of	of	ADP
bionys-549	279	3	molecular	molecular	ADJ
bionys-549	279	4	modeling	modeling	NOUN
bionys-549	279	5	,	,	PUNCT
bionys-549	279	6	18	18	NUM
bionys-549	279	7	,	,	PUNCT
bionys-549	279	8	17911799	17911799	NUM
bionys-549	279	9	.	.	PUNCT
bionys-549	280	1	madić	madić	NOUN
bionys-549	280	2	,	,	PUNCT
bionys-549	280	3	v.	v.	ADV
bionys-549	280	4	,	,	PUNCT
bionys-549	280	5	jovanović	jovanović	PROPN
bionys-549	280	6	,	,	PUNCT
bionys-549	280	7	j.	j.	PROPN
bionys-549	280	8	,	,	PUNCT
bionys-549	280	9	stojilković	stojilković	PROPN
bionys-549	280	10	,	,	PUNCT
bionys-549	280	11	a.	a.	NOUN
bionys-549	280	12	,	,	PUNCT
bionys-549	280	13	&	&	CCONJ
bionys-549	280	14	vasiljević	vasiljević	PROPN
bionys-549	280	15	,	,	PUNCT
bionys-549	280	16	p.	p.	NOUN
bionys-549	280	17	(	(	PUNCT
bionys-549	280	18	2017	2017	NUM
bionys-549	280	19	)	)	PUNCT
bionys-549	280	20	.	.	PUNCT
bionys-549	281	1	evaluation	evaluation	NOUN
bionys-549	281	2	of	of	ADP
bionys-549	281	3	cytotoxicity	cytotoxicity	NOUN
bionys-549	281	4	of	of	ADP
bionys-549	281	5	‘	'	PUNCT
bionys-549	281	6	anti	anti	ADJ
bionys-549	281	7	-	-	ADJ
bionys-549	281	8	diabetic’herbal	diabetic’herbal	ADJ
bionys-549	281	9	preparation	preparation	NOUN
bionys-549	281	10	and	and	CCONJ
bionys-549	281	11	five	five	NUM
bionys-549	281	12	medicinal	medicinal	ADJ
bionys-549	281	13	plants	plant	NOUN
bionys-549	281	14	:	:	PUNCT
bionys-549	281	15	an	an	DET
bionys-549	281	16	allium	allium	NOUN
bionys-549	281	17	cepa	cepa	NOUN
bionys-549	281	18	assay	assay	VERB
bionys-549	281	19	.	.	PUNCT
bionys-549	282	1	biologica	biologica	PROPN
bionys-549	282	2	nyssana	nyssana	PROPN
bionys-549	282	3	,	,	PUNCT
bionys-549	282	4	8(2	8(2	NUM
bionys-549	282	5	)	)	PUNCT
bionys-549	282	6	,	,	PUNCT
bionys-549	282	7	151	151	NUM
bionys-549	282	8	-	-	SYM
bionys-549	282	9	158	158	NUM
bionys-549	282	10	.	.	PUNCT
bionys-549	283	1	rajeswari	rajeswari	ADJ
bionys-549	283	2	,	,	PUNCT
bionys-549	283	3	m.	m.	NOUN
bionys-549	283	4	,	,	PUNCT
bionys-549	283	5	santhi	santhi	ADJ
bionys-549	283	6	,	,	PUNCT
bionys-549	283	7	n.	n.	NOUN
bionys-549	283	8	,	,	PUNCT
bionys-549	283	9	&	&	CCONJ
bionys-549	283	10	bhuvaneswari	bhuvaneswari	PROPN
bionys-549	283	11	,	,	PUNCT
bionys-549	283	12	v.	v.	PROPN
bionys-549	283	13	(	(	PUNCT
bionys-549	283	14	2014	2014	NUM
bionys-549	283	15	)	)	PUNCT
bionys-549	283	16	.	.	PUNCT
bionys-549	284	1	pharmacophore	pharmacophore	NOUN
bionys-549	284	2	and	and	CCONJ
bionys-549	284	3	virtual	virtual	ADJ
bionys-549	284	4	screening	screening	NOUN
bionys-549	284	5	of	of	ADP
bionys-549	284	6	jak3	jak3	NOUN
bionys-549	284	7	inhibitors	inhibitor	NOUN
bionys-549	284	8	.	.	PUNCT
bionys-549	285	1	bioinformation	bioinformation	NOUN
bionys-549	285	2	,	,	PUNCT
bionys-549	285	3	10(3	10(3	NUM
bionys-549	285	4	)	)	PUNCT
bionys-549	285	5	,	,	PUNCT
bionys-549	285	6	157	157	NUM
bionys-549	285	7	.	.	PUNCT
bionys-549	286	1	saeed	saeed	PROPN
bionys-549	286	2	,	,	PUNCT
bionys-549	286	3	m.	m.	NOUN
bionys-549	286	4	,	,	PUNCT
bionys-549	286	5	tasleem	tasleem	NOUN
bionys-549	286	6	,	,	PUNCT
bionys-549	286	7	m.	m.	NOUN
bionys-549	286	8	,	,	PUNCT
bionys-549	286	9	shoib	shoib	NOUN
bionys-549	286	10	,	,	PUNCT
bionys-549	286	11	a.	a.	NOUN
bionys-549	286	12	,	,	PUNCT
bionys-549	286	13	kausar	kausar	PROPN
bionys-549	286	14	,	,	PUNCT
bionys-549	286	15	m.a	m.a	PROPN
bionys-549	286	16	.	.	PROPN
bionys-549	286	17	,	,	PUNCT
bionys-549	286	18	sulieman	sulieman	NOUN
bionys-549	286	19	,	,	PUNCT
bionys-549	286	20	a.m.e	a.m.e	NOUN
bionys-549	286	21	.	.	PROPN
bionys-549	286	22	,	,	PUNCT
bionys-549	286	23	alabdallah	alabdallah	PROPN
bionys-549	286	24	,	,	PUNCT
bionys-549	286	25	n.m	n.m	PROPN
bionys-549	286	26	.	.	PROPN
bionys-549	286	27	,	,	PUNCT
bionys-549	286	28	el	el	PROPN
bionys-549	286	29	asmar	asmar	PROPN
bionys-549	286	30	,	,	PUNCT
bionys-549	286	31	z.	z.	PROPN
bionys-549	286	32	,	,	PUNCT
bionys-549	286	33	abdelgadir	abdelgadir	PROPN
bionys-549	286	34	,	,	PUNCT
bionys-549	286	35	a.	a.	PROPN
bionys-549	286	36	,	,	PUNCT
bionys-549	286	37	al	al	PROPN
bionys-549	286	38	-	-	PUNCT
bionys-549	286	39	shammary	shammary	ADJ
bionys-549	286	40	,	,	PUNCT
bionys-549	286	41	a.	a.	NOUN
bionys-549	286	42	,	,	PUNCT
bionys-549	286	43	alam	alam	PROPN
bionys-549	286	44	,	,	PUNCT
bionys-549	286	45	m.j	m.j	PROPN
bionys-549	286	46	.	.	PROPN
bionys-549	286	47	,	,	PUNCT
bionys-549	286	48	&	&	CCONJ
bionys-549	286	49	badroui	badroui	PROPN
bionys-549	286	50	,	,	PUNCT
bionys-549	286	51	r.	r.	PROPN
bionys-549	286	52	(	(	PUNCT
bionys-549	286	53	2022	2022	NUM
bionys-549	286	54	)	)	PUNCT
bionys-549	286	55	.	.	PUNCT
bionys-549	287	1	identification	identification	NOUN
bionys-549	287	2	of	of	ADP
bionys-549	287	3	putative	putative	ADJ
bionys-549	287	4	plant	plant	NOUN
bionys-549	287	5	-	-	PUNCT
bionys-549	287	6	based	base	VERB
bionys-549	287	7	alr-2	alr-2	PUNCT
bionys-549	287	8	inhibitors	inhibitor	NOUN
bionys-549	287	9	to	to	PART
bionys-549	287	10	treat	treat	VERB
bionys-549	287	11	diabetic	diabetic	ADJ
bionys-549	287	12	peripheral	peripheral	ADJ
bionys-549	287	13	neuropathy	neuropathy	ADJ
bionys-549	287	14	.	.	PUNCT
bionys-549	288	1	current	current	ADJ
bionys-549	288	2	issues	issue	NOUN
bionys-549	288	3	in	in	ADP
bionys-549	288	4	molecular	molecular	ADJ
bionys-549	288	5	biology	biology	NOUN
bionys-549	288	6	,	,	PUNCT
bionys-549	288	7	44(7	44(7	NOUN
bionys-549	288	8	)	)	PUNCT
bionys-549	288	9	,	,	PUNCT
bionys-549	288	10	2825	2825	NUM
bionys-549	288	11	-	-	SYM
bionys-549	288	12	2841	2841	NUM
bionys-549	288	13	.	.	PUNCT
bionys-549	289	1	singh	singh	PROPN
bionys-549	289	2	,	,	PUNCT
bionys-549	289	3	m.	m.	NOUN
bionys-549	289	4	,	,	PUNCT
bionys-549	289	5	kapoor	kapoor	PROPN
bionys-549	289	6	,	,	PUNCT
bionys-549	289	7	a.	a.	PROPN
bionys-549	289	8	,	,	PUNCT
bionys-549	289	9	&	&	CCONJ
bionys-549	289	10	bhatnagar	bhatnagar	PROPN
bionys-549	289	11	,	,	PUNCT
bionys-549	289	12	a.	a.	NOUN
bionys-549	289	13	(	(	PUNCT
bionys-549	289	14	2021	2021	NUM
bionys-549	289	15	)	)	PUNCT
bionys-549	289	16	.	.	PUNCT
bionys-549	290	1	physiological	physiological	ADJ
bionys-549	290	2	and	and	CCONJ
bionys-549	290	3	pathological	pathological	ADJ
bionys-549	290	4	roles	role	NOUN
bionys-549	290	5	of	of	ADP
bionys-549	290	6	aldose	aldose	DET
bionys-549	290	7	reductase	reductase	NOUN
bionys-549	290	8	.	.	PUNCT
bionys-549	291	1	metabolites	metabolite	NOUN
bionys-549	291	2	,	,	PUNCT
bionys-549	291	3	11(10	11(10	NUM
bionys-549	291	4	)	)	PUNCT
bionys-549	291	5	,	,	PUNCT
bionys-549	291	6	p.655	p.655	NOUN
bionys-549	291	7	.	.	PUNCT
bionys-549	292	1	sulaiman	sulaiman	PROPN
bionys-549	292	2	,	,	PUNCT
bionys-549	292	3	a.h	a.h	PROPN
bionys-549	292	4	.	.	PROPN
bionys-549	292	5	,	,	PUNCT
bionys-549	292	6	ghassan	ghassan	PROPN
bionys-549	292	7	,	,	PUNCT
bionys-549	292	8	z.i	z.i	PROPN
bionys-549	292	9	.	.	PROPN
bionys-549	292	10	,	,	PUNCT
bionys-549	292	11	&	&	CCONJ
bionys-549	292	12	omar	omar	PROPN
bionys-549	292	13	,	,	PUNCT
bionys-549	292	14	t.n	t.n	PROPN
bionys-549	292	15	.	.	PROPN
bionys-549	292	16	(	(	PUNCT
bionys-549	292	17	2022	2022	NUM
bionys-549	292	18	)	)	PUNCT
bionys-549	292	19	.	.	PUNCT
bionys-549	293	1	biochemical	biochemical	ADJ
bionys-549	293	2	evaluation	evaluation	NOUN
bionys-549	293	3	of	of	ADP
bionys-549	293	4	carbonic	carbonic	ADJ
bionys-549	293	5	anhydrase	anhydrase	NOUN
bionys-549	293	6	and	and	CCONJ
bionys-549	293	7	some	some	DET
bionys-549	293	8	antioxidant	antioxidant	ADJ
bionys-549	293	9	markers	marker	NOUN
bionys-549	293	10	in	in	ADP
bionys-549	293	11	patients	patient	NOUN
bionys-549	293	12	with	with	ADP
bionys-549	293	13	diabetes	diabetes	NOUN
bionys-549	293	14	complications	complication	NOUN
bionys-549	293	15	.	.	PUNCT
bionys-549	294	1	archives	archive	NOUN
bionys-549	294	2	of	of	ADP
bionys-549	294	3	razi	razi	PROPN
bionys-549	294	4	institute	institute	PROPN
bionys-549	294	5	,	,	PUNCT
bionys-549	294	6	77(1	77(1	NUM
bionys-549	294	7	)	)	PUNCT
bionys-549	294	8	,	,	PUNCT
bionys-549	294	9	169	169	NUM
bionys-549	294	10	-	-	SYM
bionys-549	294	11	178	178	NUM
bionys-549	294	12	.	.	PUNCT
bionys-549	295	1	twarda	twarda	NOUN
bionys-549	295	2	-	-	PUNCT
bionys-549	295	3	clapa	clapa	VERB
bionys-549	295	4	,	,	PUNCT
bionys-549	295	5	a.	a.	NOUN
bionys-549	295	6	,	,	PUNCT
bionys-549	295	7	olczak	olczak	PROPN
bionys-549	295	8	,	,	PUNCT
bionys-549	295	9	a.	a.	NOUN
bionys-549	295	10	,	,	PUNCT
bionys-549	295	11	białkowska	białkowska	PROPN
bionys-549	295	12	,	,	PUNCT
bionys-549	295	13	a.m.	a.m.	ADV
bionys-549	295	14	,	,	PUNCT
bionys-549	295	15	&	&	CCONJ
bionys-549	295	16	koziołkiewicz	koziołkiewicz	PROPN
bionys-549	295	17	,	,	PUNCT
bionys-549	295	18	m.	m.	NOUN
bionys-549	295	19	(	(	PUNCT
bionys-549	295	20	2022	2022	NUM
bionys-549	295	21	)	)	PUNCT
bionys-549	295	22	.	.	PUNCT
bionys-549	296	1	advanced	advanced	ADJ
bionys-549	296	2	glycation	glycation	NOUN
bionys-549	296	3	end	end	NOUN
bionys-549	296	4	-	-	PUNCT
bionys-549	296	5	products	product	NOUN
bionys-549	296	6	(	(	PUNCT
bionys-549	296	7	ages	age	NOUN
bionys-549	296	8	):	):	PUNCT
bionys-549	296	9	formation	formation	NOUN
bionys-549	296	10	,	,	PUNCT
bionys-549	296	11	chemistry	chemistry	NOUN
bionys-549	296	12	,	,	PUNCT
bionys-549	296	13	classification	classification	NOUN
bionys-549	296	14	,	,	PUNCT
bionys-549	296	15	receptors	receptor	NOUN
bionys-549	296	16	,	,	PUNCT
bionys-549	296	17	and	and	CCONJ
bionys-549	296	18	diseases	disease	NOUN
bionys-549	296	19	related	relate	VERB
bionys-549	296	20	to	to	ADP
bionys-549	296	21	ages	age	NOUN
bionys-549	296	22	.	.	PUNCT
bionys-549	297	1	cells	cell	NOUN
bionys-549	297	2	,	,	PUNCT
bionys-549	297	3	11(8	11(8	NUM
bionys-549	297	4	)	)	PUNCT
bionys-549	297	5	,	,	PUNCT
bionys-549	297	6	1312	1312	NUM
bionys-549	297	7	.	.	PUNCT
bionys-549	298	1	verma	verma	PROPN
bionys-549	298	2	,	,	PUNCT
bionys-549	298	3	s.k	s.k	PROPN
bionys-549	298	4	.	.	PROPN
bionys-549	298	5	&	&	CCONJ
bionys-549	298	6	thareja	thareja	PROPN
bionys-549	298	7	,	,	PUNCT
bionys-549	298	8	s.	s.	PROPN
bionys-549	298	9	(	(	PUNCT
bionys-549	298	10	2020	2020	NUM
bionys-549	298	11	)	)	PUNCT
bionys-549	298	12	.	.	PUNCT
bionys-549	299	1	an	an	DET
bionys-549	299	2	overview	overview	NOUN
bionys-549	299	3	on	on	ADP
bionys-549	299	4	chemistry	chemistry	NOUN
bionys-549	299	5	of	of	ADP
bionys-549	299	6	natural	natural	ADJ
bionys-549	299	7	aldose	aldose	ADJ
bionys-549	299	8	reductase	reductase	NOUN
bionys-549	299	9	inhibitors	inhibitor	NOUN
bionys-549	299	10	for	for	ADP
bionys-549	299	11	the	the	DET
bionys-549	299	12	management	management	NOUN
bionys-549	299	13	of	of	ADP
bionys-549	299	14	diabetic	diabetic	ADJ
bionys-549	299	15	complications	complication	NOUN
bionys-549	299	16	.	.	PUNCT
bionys-549	300	1	studies	study	NOUN
bionys-549	300	2	in	in	ADP
bionys-549	300	3	natural	natural	ADJ
bionys-549	300	4	products	product	NOUN
bionys-549	300	5	chemistry	chemistry	NOUN
bionys-549	300	6	,	,	PUNCT
bionys-549	300	7	65	65	NUM
bionys-549	300	8	,	,	PUNCT
bionys-549	300	9	381	381	NUM
bionys-549	300	10	-	-	SYM
bionys-549	300	11	429	429	NUM
bionys-549	300	12	.	.	PUNCT
bionys-549	301	1	yagihashi	yagihashi	PROPN
bionys-549	301	2	,	,	PUNCT
bionys-549	301	3	s.	s.	PROPN
bionys-549	301	4	,	,	PUNCT
bionys-549	301	5	mizukami	mizukami	NOUN
bionys-549	301	6	,	,	PUNCT
bionys-549	301	7	h.	h.	PROPN
bionys-549	301	8	,	,	PUNCT
bionys-549	301	9	&	&	CCONJ
bionys-549	301	10	sugimoto	sugimoto	PROPN
bionys-549	301	11	,	,	PUNCT
bionys-549	301	12	k.	k.	PROPN
bionys-549	301	13	(	(	PUNCT
bionys-549	301	14	2011	2011	NUM
bionys-549	301	15	)	)	PUNCT
bionys-549	301	16	.	.	PUNCT
bionys-549	302	1	mechanism	mechanism	NOUN
bionys-549	302	2	of	of	ADP
bionys-549	302	3	diabetic	diabetic	NOUN
bionys-549	302	4	neuropathy	neuropathy	ADJ
bionys-549	302	5	:	:	PUNCT
bionys-549	302	6	where	where	SCONJ
bionys-549	302	7	are	be	AUX
bionys-549	302	8	we	we	PRON
bionys-549	302	9	now	now	ADV
bionys-549	302	10	and	and	CCONJ
bionys-549	302	11	where	where	SCONJ
bionys-549	302	12	to	to	PART
bionys-549	302	13	go	go	VERB
bionys-549	302	14	?	?	PUNCT
bionys-549	302	15	.	.	PUNCT
bionys-549	303	1	journal	journal	PROPN
bionys-549	303	2	of	of	ADP
bionys-549	303	3	diabetes	diabetes	NOUN
bionys-549	303	4	investigation	investigation	NOUN
bionys-549	303	5	,	,	PUNCT
bionys-549	303	6	2(1	2(1	NUM
bionys-549	303	7	)	)	PUNCT
bionys-549	303	8	,	,	PUNCT
bionys-549	303	9	18	18	NUM
bionys-549	303	10	-	-	SYM
bionys-549	303	11	32	32	NUM
bionys-549	303	12	.	.	PUNCT
bionys-549	304	1	zhang	zhang	PROPN
bionys-549	304	2	,	,	PUNCT
bionys-549	304	3	k.	k.	PROPN
bionys-549	304	4	,	,	PUNCT
bionys-549	304	5	lu	lu	PROPN
bionys-549	304	6	,	,	PUNCT
bionys-549	304	7	w.c	w.c	PROPN
bionys-549	304	8	.	.	PROPN
bionys-549	304	9	,	,	PUNCT
bionys-549	304	10	zhang	zhang	PROPN
bionys-549	304	11	,	,	PUNCT
bionys-549	304	12	m.	m.	NOUN
bionys-549	304	13	,	,	PUNCT
bionys-549	304	14	zhang	zhang	PROPN
bionys-549	304	15	,	,	PUNCT
bionys-549	304	16	q.	q.	PROPN
bionys-549	304	17	,	,	PUNCT
bionys-549	304	18	xian	xian	PROPN
bionys-549	304	19	,	,	PUNCT
bionys-549	304	20	p.p	p.p	PROPN
bionys-549	304	21	.	.	PROPN
bionys-549	304	22	,	,	PUNCT
bionys-549	304	23	liu	liu	PROPN
bionys-549	304	24	,	,	PUNCT
bionys-549	304	25	f.f	f.f	PROPN
bionys-549	304	26	.	.	PROPN
bionys-549	304	27	,	,	PUNCT
bionys-549	304	28	chen	chen	PROPN
bionys-549	304	29	,	,	PUNCT
bionys-549	304	30	z.y	z.y	PROPN
bionys-549	304	31	.	.	PROPN
bionys-549	304	32	,	,	PUNCT
bionys-549	304	33	kim	kim	PROPN
bionys-549	304	34	,	,	PUNCT
bionys-549	304	35	c.s	c.s	PROPN
bionys-549	304	36	.	.	PROPN
bionys-549	304	37	,	,	PUNCT
bionys-549	304	38	wu	wu	PROPN
bionys-549	304	39	,	,	PUNCT
bionys-549	304	40	s.x	s.x	PROPN
bionys-549	304	41	.	.	PROPN
bionys-549	304	42	,	,	PUNCT
bionys-549	304	43	tao	tao	PROPN
bionys-549	304	44	,	,	PUNCT
bionys-549	304	45	h.r	h.r	PROPN
bionys-549	304	46	.	.	PROPN
bionys-549	304	47	,	,	PUNCT
bionys-549	304	48	&	&	CCONJ
bionys-549	304	49	wang	wang	PROPN
bionys-549	304	50	,	,	PUNCT
bionys-549	304	51	y.z	y.z	PROPN
bionys-549	304	52	.	.	PROPN
bionys-549	304	53	(	(	PUNCT
bionys-549	304	54	2022	2022	NUM
bionys-549	304	55	)	)	PUNCT
bionys-549	304	56	.	.	PUNCT
bionys-549	305	1	reducing	reduce	VERB
bionys-549	305	2	host	host	NOUN
bionys-549	305	3	aldose	aldose	PRON
bionys-549	305	4	reductase	reductase	NOUN
bionys-549	305	5	activity	activity	NOUN
bionys-549	305	6	promotes	promote	VERB
bionys-549	305	7	neuronal	neuronal	ADJ
bionys-549	305	8	differentiation	differentiation	NOUN
bionys-549	305	9	of	of	ADP
bionys-549	305	10	transplanted	transplanted	ADJ
bionys-549	305	11	neural	neural	ADJ
bionys-549	305	12	stem	stem	NOUN
bionys-549	305	13	cells	cell	NOUN
bionys-549	305	14	at	at	ADP
bionys-549	305	15	spinal	spinal	PROPN
bionys-549	305	16	cord	cord	NOUN
bionys-549	305	17	injury	injury	NOUN
bionys-549	305	18	sites	site	NOUN
bionys-549	305	19	and	and	CCONJ
bionys-549	305	20	facilitates	facilitate	VERB
bionys-549	305	21	locomotion	locomotion	NOUN
bionys-549	305	22	recovery	recovery	NOUN
bionys-549	305	23	.	.	PUNCT
bionys-549	306	1	neural	neural	ADJ
bionys-549	306	2	regeneration	regeneration	NOUN
bionys-549	306	3	research	research	NOUN
bionys-549	306	4	,	,	PUNCT
bionys-549	306	5	17(8	17(8	NUM
bionys-549	306	6	)	)	PUNCT
bionys-549	306	7	,	,	PUNCT
bionys-549	306	8	1814	1814	NUM
bionys-549	306	9	-	-	SYM
bionys-549	306	10	1820	1820	NUM
bionys-549	306	11	.	.	PUNCT
bionys-549	307	1	zheng	zheng	PROPN
bionys-549	307	2	,	,	PUNCT
bionys-549	307	3	q.	q.	PROPN
bionys-549	307	4	,	,	PUNCT
bionys-549	307	5	li	li	PROPN
bionys-549	307	6	,	,	PUNCT
bionys-549	307	7	s.	s.	PROPN
bionys-549	307	8	,	,	PUNCT
bionys-549	307	9	li	li	PROPN
bionys-549	307	10	,	,	PUNCT
bionys-549	307	11	x.	x.	PROPN
bionys-549	307	12	,	,	PUNCT
bionys-549	307	13	&	&	CCONJ
bionys-549	307	14	liu	liu	PROPN
bionys-549	307	15	,	,	PUNCT
bionys-549	307	16	r.	r.	PROPN
bionys-549	307	17	(	(	PUNCT
bionys-549	307	18	2021	2021	NUM
bionys-549	307	19	)	)	PUNCT
bionys-549	307	20	.	.	PUNCT
bionys-549	308	1	advances	advance	NOUN
bionys-549	308	2	in	in	ADP
bionys-549	308	3	the	the	DET
bionys-549	308	4	study	study	NOUN
bionys-549	308	5	of	of	ADP
bionys-549	308	6	emodin	emodin	PROPN
bionys-549	308	7	:	:	PUNCT
bionys-549	308	8	an	an	DET
bionys-549	308	9	update	update	NOUN
bionys-549	308	10	on	on	ADP
bionys-549	308	11	pharmacological	pharmacological	ADJ
bionys-549	308	12	properties	property	NOUN
bionys-549	308	13	and	and	CCONJ
bionys-549	308	14	mechanistic	mechanistic	ADJ
bionys-549	308	15	basis	basis	NOUN
bionys-549	308	16	.	.	PUNCT
bionys-549	309	1	chinese	chinese	ADJ
bionys-549	309	2	medicine	medicine	NOUN
bionys-549	309	3	,	,	PUNCT
bionys-549	309	4	16	16	NUM
bionys-549	309	5	,	,	PUNCT
bionys-549	309	6	1	1	NUM
bionys-549	309	7	-	-	SYM
bionys-549	309	8	24	24	NUM
bionys-549	309	9	.	.	PUNCT
bionys-549	310	1	zhu	zhu	PROPN
bionys-549	310	2	,	,	PUNCT
bionys-549	310	3	j.	j.	PROPN
bionys-549	310	4	,	,	PUNCT
bionys-549	310	5	qi	qi	PROPN
bionys-549	310	6	,	,	PUNCT
bionys-549	310	7	g.	g.	PROPN
bionys-549	310	8	,	,	PUNCT
bionys-549	310	9	kuang	kuang	PROPN
bionys-549	310	10	,	,	PUNCT
bionys-549	310	11	y.	y.	PROPN
bionys-549	310	12	,	,	PUNCT
bionys-549	310	13	zhao	zhao	PROPN
bionys-549	310	14	,	,	PUNCT
bionys-549	310	15	y.	y.	PROPN
bionys-549	310	16	,	,	PUNCT
bionys-549	310	17	sun	sun	PROPN
bionys-549	310	18	,	,	PUNCT
bionys-549	310	19	x.	x.	PROPN
bionys-549	310	20	,	,	PUNCT
bionys-549	310	21	zhu	zhu	PROPN
bionys-549	310	22	,	,	PUNCT
bionys-549	310	23	c.	c.	PROPN
bionys-549	310	24	,	,	PUNCT
bionys-549	310	25	hao	hao	PROPN
bionys-549	310	26	,	,	PUNCT
bionys-549	310	27	x.	x.	PROPN
bionys-549	310	28	,	,	PUNCT
bionys-549	310	29	&	&	CCONJ
bionys-549	310	30	han	han	PROPN
bionys-549	310	31	,	,	PUNCT
bionys-549	310	32	z.	z.	PROPN
bionys-549	310	33	(	(	PUNCT
bionys-549	310	34	2022	2022	NUM
bionys-549	310	35	)	)	PUNCT
bionys-549	310	36	.	.	PUNCT
bionys-549	311	1	identification	identification	NOUN
bionys-549	311	2	of	of	ADP
bionys-549	311	3	9h‐	9h‐	NUM
bionys-549	311	4	purin‐6‐amine	purin‐6‐amine	NUM
bionys-549	311	5	derivatives	derivative	NOUN
bionys-549	311	6	as	as	ADP
bionys-549	311	7	novel	novel	NOUN
bionys-549	311	8	aldose	aldose	ADJ
bionys-549	311	9	reductase	reductase	NOUN
bionys-549	311	10	inhibitors	inhibitor	NOUN
bionys-549	311	11	for	for	ADP
bionys-549	311	12	the	the	DET
bionys-549	311	13	treatment	treatment	NOUN
bionys-549	311	14	of	of	ADP
bionys-549	311	15	diabetic	diabetic	ADJ
bionys-549	311	16	complications	complication	NOUN
bionys-549	311	17	.	.	PUNCT
bionys-549	312	1	archiv	archiv	PROPN
bionys-549	312	2	der	der	PROPN
bionys-549	312	3	pharmazie	pharmazie	PROPN
bionys-549	312	4	,	,	PUNCT
bionys-549	312	5	355(8	355(8	NUM
bionys-549	312	6	)	)	PUNCT
bionys-549	312	7	,	,	PUNCT
bionys-549	312	8	2200043	2200043	NUM
bionys-549	312	9	.	.	PUNCT
bionys-549	313	1	133	133	NUM