id	sid	tid	token	lemma	pos
bionys-589	1	1	alex	alex	PROPN
bionys-589	1	2	et	et	PROPN
bionys-589	1	3	al	al	PROPN
bionys-589	1	4	.	.	PROPN
bionys-589	1	5	2025	2025	NUM
bionys-589	1	6	,	,	PUNCT
bionys-589	2	1	biologica	biologica	PROPN
bionys-589	2	2	nyssana	nyssana	PROPN
bionys-589	2	3	16(1	16(1	PROPN
bionys-589	2	4	)	)	PUNCT
bionys-589	2	5	267	267	NUM
bionys-589	2	6	16	16	NUM
bionys-589	2	7	(	(	PUNCT
bionys-589	2	8	1	1	NUM
bionys-589	2	9	)	)	PUNCT
bionys-589	2	10	june	june	PROPN
bionys-589	2	11	2025	2025	NUM
bionys-589	2	12	:	:	PUNCT
bionys-589	2	13	267	267	NUM
bionys-589	2	14	-	-	SYM
bionys-589	2	15	276	276	NUM
bionys-589	2	16	doi	doi	NOUN
bionys-589	2	17	:	:	PUNCT
bionys-589	2	18	10.46793	10.46793	NUM
bionys-589	2	19	/	/	SYM
bionys-589	2	20	biolnyss.16.1.23a	biolnyss.16.1.23a	ADJ
bionys-589	2	21	formulation	formulation	NOUN
bionys-589	2	22	and	and	CCONJ
bionys-589	2	23	characterization	characterization	NOUN
bionys-589	2	24	of	of	ADP
bionys-589	2	25	nanoparticles	nanoparticle	NOUN
bionys-589	2	26	loaded	load	VERB
bionys-589	2	27	with	with	ADP
bionys-589	2	28	curcumin	curcumin	NOUN
bionys-589	2	29	and	and	CCONJ
bionys-589	2	30	amantadine	amantadine	NOUN
bionys-589	2	31	as	as	ADP
bionys-589	2	32	a	a	DET
bionys-589	2	33	promising	promising	ADJ
bionys-589	2	34	neuroprotective	neuroprotective	ADJ
bionys-589	2	35	agent	agent	NOUN
bionys-589	2	36	original	original	ADJ
bionys-589	2	37	article	article	NOUN
bionys-589	2	38	aksa	aksa	PROPN
bionys-589	2	39	alex	alex	PROPN
bionys-589	2	40	department	department	PROPN
bionys-589	2	41	of	of	ADP
bionys-589	2	42	pharmaceutics	pharmaceutic	NOUN
bionys-589	2	43	,	,	PUNCT
bionys-589	2	44	faculty	faculty	NOUN
bionys-589	2	45	of	of	ADP
bionys-589	2	46	pharmacy	pharmacy	NOUN
bionys-589	2	47	,	,	PUNCT
bionys-589	2	48	karpagam	karpagam	PROPN
bionys-589	2	49	academy	academy	PROPN
bionys-589	2	50	of	of	ADP
bionys-589	2	51	higher	high	ADJ
bionys-589	2	52	education	education	NOUN
bionys-589	2	53	,	,	PUNCT
bionys-589	2	54	coimbatore	coimbatore	PROPN
bionys-589	2	55	,	,	PUNCT
bionys-589	2	56	tamilnadu	tamilnadu	NOUN
bionys-589	2	57	,	,	PUNCT
bionys-589	2	58	india	india	PROPN
bionys-589	2	59	apsara	apsara	PROPN
bionys-589	2	60	unni	unni	PROPN
bionys-589	2	61	research	research	PROPN
bionys-589	2	62	scholar	scholar	NOUN
bionys-589	2	63	,	,	PUNCT
bionys-589	2	64	department	department	NOUN
bionys-589	2	65	of	of	ADP
bionys-589	2	66	pharmaceutical	pharmaceutical	ADJ
bionys-589	2	67	chemistry	chemistry	NOUN
bionys-589	2	68	,	,	PUNCT
bionys-589	2	69	jss	jss	PROPN
bionys-589	2	70	college	college	PROPN
bionys-589	2	71	of	of	ADP
bionys-589	2	72	pharmacy	pharmacy	NOUN
bionys-589	2	73	,	,	PUNCT
bionys-589	2	74	ooty	ooty	PROPN
bionys-589	2	75	,	,	PUNCT
bionys-589	2	76	tamilnadu	tamilnadu	PROPN
bionys-589	2	77	,	,	PUNCT
bionys-589	2	78	india	india	PROPN
bionys-589	2	79	gayathri	gayathri	PROPN
bionys-589	2	80	kumararaja	kumararaja	PROPN
bionys-589	2	81	department	department	PROPN
bionys-589	2	82	of	of	ADP
bionys-589	2	83	pharmaceutics	pharmaceutic	NOUN
bionys-589	2	84	,	,	PUNCT
bionys-589	2	85	faculty	faculty	NOUN
bionys-589	2	86	of	of	ADP
bionys-589	2	87	pharmacy	pharmacy	NOUN
bionys-589	2	88	,	,	PUNCT
bionys-589	2	89	karpagam	karpagam	PROPN
bionys-589	2	90	academy	academy	PROPN
bionys-589	2	91	of	of	ADP
bionys-589	2	92	higher	high	ADJ
bionys-589	2	93	education	education	NOUN
bionys-589	2	94	,	,	PUNCT
bionys-589	2	95	coimbatore	coimbatore	PROPN
bionys-589	2	96	,	,	PUNCT
bionys-589	2	97	tamilnadu	tamilnadu	NOUN
bionys-589	2	98	,	,	PUNCT
bionys-589	2	99	india	india	PROPN
bionys-589	2	100	gayubpharm@gmail.com	gayubpharm@gmail.com	PROPN
bionys-589	2	101	(	(	PUNCT
bionys-589	2	102	corresponding	corresponding	ADJ
bionys-589	2	103	author	author	NOUN
bionys-589	2	104	)	)	PUNCT
bionys-589	2	105	received	receive	VERB
bionys-589	2	106	:	:	PUNCT
bionys-589	2	107	january	january	PROPN
bionys-589	2	108	30	30	NUM
bionys-589	2	109	,	,	PUNCT
bionys-589	2	110	2025	2025	NUM
bionys-589	2	111	revised	revise	VERB
bionys-589	2	112	:	:	PUNCT
bionys-589	2	113	april	april	PROPN
bionys-589	2	114	25	25	NUM
bionys-589	2	115	,	,	PUNCT
bionys-589	2	116	2025	2025	NUM
bionys-589	2	117	accepted	accept	VERB
bionys-589	2	118	:	:	PUNCT
bionys-589	2	119	april	april	PROPN
bionys-589	2	120	28	28	NUM
bionys-589	2	121	,	,	PUNCT
bionys-589	2	122	2025	2025	NUM
bionys-589	2	123	abstract	abstract	NOUN
bionys-589	2	124	:	:	PUNCT
bionys-589	2	125	parkinson	parkinson	NOUN
bionys-589	2	126	's	's	PART
bionys-589	2	127	disease	disease	NOUN
bionys-589	2	128	(	(	PUNCT
bionys-589	2	129	pd	pd	NOUN
bionys-589	2	130	)	)	PUNCT
bionys-589	2	131	is	be	AUX
bionys-589	2	132	regarded	regard	VERB
bionys-589	2	133	as	as	ADP
bionys-589	2	134	the	the	DET
bionys-589	2	135	second	second	ADJ
bionys-589	2	136	most	most	ADV
bionys-589	2	137	common	common	ADJ
bionys-589	2	138	neurodegenerative	neurodegenerative	ADJ
bionys-589	2	139	disease	disease	NOUN
bionys-589	2	140	and	and	CCONJ
bionys-589	2	141	is	be	AUX
bionys-589	2	142	characterized	characterize	VERB
bionys-589	2	143	by	by	ADP
bionys-589	2	144	observable	observable	ADJ
bionys-589	2	145	motor	motor	NOUN
bionys-589	2	146	dysfunction	dysfunction	NOUN
bionys-589	2	147	and	and	CCONJ
bionys-589	2	148	loss	loss	NOUN
bionys-589	2	149	of	of	ADP
bionys-589	2	150	dopaminergic	dopaminergic	ADJ
bionys-589	2	151	neurons	neuron	NOUN
bionys-589	2	152	.	.	PUNCT
bionys-589	3	1	to	to	ADP
bionys-589	3	2	date	date	NOUN
bionys-589	3	3	,	,	PUNCT
bionys-589	3	4	there	there	PRON
bionys-589	3	5	is	be	VERB
bionys-589	3	6	no	no	DET
bionys-589	3	7	cure	cure	NOUN
bionys-589	3	8	for	for	ADP
bionys-589	3	9	pd	pd	NOUN
bionys-589	3	10	,	,	PUNCT
bionys-589	3	11	nor	nor	CCONJ
bionys-589	3	12	the	the	DET
bionys-589	3	13	treatment	treatment	NOUN
bionys-589	3	14	that	that	PRON
bionys-589	3	15	stops	stop	VERB
bionys-589	3	16	its	its	PRON
bionys-589	3	17	progression	progression	NOUN
bionys-589	3	18	.	.	PUNCT
bionys-589	4	1	nanotechnology	nanotechnology	NOUN
bionys-589	4	2	is	be	AUX
bionys-589	4	3	very	very	ADV
bionys-589	4	4	useful	useful	ADJ
bionys-589	4	5	for	for	ADP
bionys-589	4	6	controlling	control	VERB
bionys-589	4	7	drug	drug	NOUN
bionys-589	4	8	release	release	NOUN
bionys-589	4	9	,	,	PUNCT
bionys-589	4	10	thus	thus	ADV
bionys-589	4	11	improving	improve	VERB
bionys-589	4	12	drug	drug	NOUN
bionys-589	4	13	pharmacokinetic	pharmacokinetic	ADJ
bionys-589	4	14	and	and	CCONJ
bionys-589	4	15	pharmacodynamic	pharmacodynamic	ADJ
bionys-589	4	16	properties	property	NOUN
bionys-589	4	17	.	.	PUNCT
bionys-589	5	1	in	in	ADP
bionys-589	5	2	this	this	DET
bionys-589	5	3	study	study	NOUN
bionys-589	5	4	,	,	PUNCT
bionys-589	5	5	we	we	PRON
bionys-589	5	6	fabricated	fabricate	VERB
bionys-589	5	7	curcumin	curcumin	NOUN
bionys-589	5	8	and	and	CCONJ
bionys-589	5	9	amantadine	amantadine	NOUN
bionys-589	5	10	-	-	PUNCT
bionys-589	5	11	loaded	load	VERB
bionys-589	5	12	nanoparticles	nanoparticle	NOUN
bionys-589	5	13	using	use	VERB
bionys-589	5	14	bovine	bovine	NOUN
bionys-589	5	15	serum	serum	NOUN
bionys-589	5	16	albumin	albumin	PROPN
bionys-589	5	17	(	(	PUNCT
bionys-589	5	18	bsa	bsa	PROPN
bionys-589	5	19	)	)	PUNCT
bionys-589	5	20	as	as	ADP
bionys-589	5	21	a	a	DET
bionys-589	5	22	nanocarrier	nanocarrier	NOUN
bionys-589	5	23	using	use	VERB
bionys-589	5	24	the	the	DET
bionys-589	5	25	desolvation	desolvation	NOUN
bionys-589	5	26	method	method	NOUN
bionys-589	5	27	.	.	PUNCT
bionys-589	6	1	encapsulating	encapsulate	VERB
bionys-589	6	2	curcumin	curcumin	NOUN
bionys-589	6	3	and	and	CCONJ
bionys-589	6	4	amantadine	amantadine	NOUN
bionys-589	6	5	were	be	AUX
bionys-589	6	6	beneficial	beneficial	ADJ
bionys-589	6	7	in	in	ADP
bionys-589	6	8	improving	improve	VERB
bionys-589	6	9	its	its	PRON
bionys-589	6	10	aqueous	aqueous	ADJ
bionys-589	6	11	solubility	solubility	NOUN
bionys-589	6	12	and	and	CCONJ
bionys-589	6	13	bioavailability	bioavailability	NOUN
bionys-589	6	14	.	.	PUNCT
bionys-589	7	1	the	the	DET
bionys-589	7	2	prepared	prepare	VERB
bionys-589	7	3	nanoparticles	nanoparticle	NOUN
bionys-589	7	4	had	have	VERB
bionys-589	7	5	the	the	DET
bionys-589	7	6	particle	particle	NOUN
bionys-589	7	7	size	size	NOUN
bionys-589	7	8	and	and	CCONJ
bionys-589	7	9	zeta	zeta	NOUN
bionys-589	7	10	potential	potential	NOUN
bionys-589	7	11	of	of	ADP
bionys-589	7	12	257	257	NUM
bionys-589	7	13	nm	nm	NOUN
bionys-589	7	14	and	and	CCONJ
bionys-589	7	15	-29	-29	PROPN
bionys-589	7	16	mv	mv	PROPN
bionys-589	7	17	,	,	PUNCT
bionys-589	7	18	respectively	respectively	ADV
bionys-589	7	19	.	.	PUNCT
bionys-589	8	1	the	the	DET
bionys-589	8	2	in	in	ADV
bionys-589	8	3	vitro	vitro	X
bionys-589	8	4	neuroprotective	neuroprotective	ADJ
bionys-589	8	5	effect	effect	NOUN
bionys-589	8	6	was	be	AUX
bionys-589	8	7	determined	determine	VERB
bionys-589	8	8	using	use	VERB
bionys-589	8	9	shsy5y	shsy5y	PROPN
bionys-589	8	10	cell	cell	NOUN
bionys-589	8	11	lines	line	NOUN
bionys-589	8	12	through	through	ADP
bionys-589	8	13	the	the	DET
bionys-589	8	14	mtt	mtt	NOUN
bionys-589	8	15	assay	assay	VERB
bionys-589	8	16	,	,	PUNCT
bionys-589	8	17	which	which	PRON
bionys-589	8	18	showed	show	VERB
bionys-589	8	19	strong	strong	ADJ
bionys-589	8	20	neuroprotective	neuroprotective	ADJ
bionys-589	8	21	activity	activity	NOUN
bionys-589	8	22	.	.	PUNCT
bionys-589	9	1	key	key	ADJ
bionys-589	9	2	words	word	NOUN
bionys-589	9	3	:	:	PUNCT
bionys-589	9	4	bovine	bovine	NOUN
bionys-589	9	5	serum	serum	NOUN
bionys-589	9	6	albumin	albumin	PROPN
bionys-589	9	7	,	,	PUNCT
bionys-589	9	8	curcumin	curcumin	NOUN
bionys-589	9	9	,	,	PUNCT
bionys-589	9	10	amantadine	amantadine	NOUN
bionys-589	9	11	,	,	PUNCT
bionys-589	9	12	desolvation	desolvation	NOUN
bionys-589	9	13	,	,	PUNCT
bionys-589	9	14	neuroprotective	neuroprotective	ADJ
bionys-589	9	15	activity	activity	NOUN
bionys-589	9	16	apstrakt	apstrakt	NOUN
bionys-589	9	17	:	:	PUNCT
bionys-589	9	18	formulisanje	formulisanje	NOUN
bionys-589	10	1	i	i	PRON
bionys-589	10	2	karakterizacija	karakterizacija	VERB
bionys-589	10	3	nanočestica	nanočestica	PROPN
bionys-589	10	4	koje	koje	PROPN
bionys-589	10	5	sadrže	sadrže	PROPN
bionys-589	10	6	kurkumin	kurkumin	PROPN
bionys-589	11	1	i	i	PRON
bionys-589	11	2	amantadin	amantadin	VERB
bionys-589	11	3	kao	kao	PROPN
bionys-589	11	4	obećavajućeg	obećavajućeg	PROPN
bionys-589	11	5	neuroprotektivnog	neuroprotektivnog	PROPN
bionys-589	11	6	agensa	agensa	PROPN
bionys-589	11	7	parkinsonova	parkinsonova	PROPN
bionys-589	11	8	bolest	bol	ADJ
bionys-589	11	9	(	(	PUNCT
bionys-589	11	10	pb	pb	ADP
bionys-589	11	11	)	)	PUNCT
bionys-589	11	12	se	se	X
bionys-589	12	1	smatra	smatra	PROPN
bionys-589	12	2	drugom	drugom	PROPN
bionys-589	12	3	najčešćom	najčešćom	PROPN
bionys-589	12	4	neurodegerativnom	neurodegerativnom	PROPN
bionys-589	12	5	bolešću	bolešću	NOUN
bionys-589	12	6	i	i	PRON
bionys-589	12	7	karakteriše	karakteriše	VERB
bionys-589	12	8	se	se	PROPN
bionys-589	12	9	izraženim	izraženim	PROPN
bionys-589	12	10	motornim	motornim	NOUN
bionys-589	12	11	disfunkcijama	disfunkcijama	NOUN
bionys-589	13	1	i	i	PRON
bionys-589	13	2	gubitkom	gubitkom	VERB
bionys-589	13	3	dopaminergičkih	dopaminergičkih	PROPN
bionys-589	13	4	neurona	neurona	PROPN
bionys-589	13	5	.	.	PUNCT
bionys-589	14	1	do	do	VERB
bionys-589	14	2	danas	danas	PROPN
bionys-589	14	3	ne	ne	PROPN
bionys-589	14	4	postoji	postoji	PROPN
bionys-589	14	5	lek	lek	PROPN
bionys-589	14	6	za	za	PROPN
bionys-589	14	7	pb	pb	PROPN
bionys-589	14	8	,	,	PUNCT
bionys-589	14	9	niti	niti	PRON
bionys-589	14	10	terapija	terapija	VERB
bionys-589	14	11	koja	koja	PROPN
bionys-589	14	12	može	može	PROPN
bionys-589	14	13	zaustaviti	zaustaviti	PROPN
bionys-589	14	14	njeno	njeno	PROPN
bionys-589	14	15	napredovanje	napredovanje	PROPN
bionys-589	14	16	.	.	PUNCT
bionys-589	15	1	nanotehnologija	nanotehnologija	PROPN
bionys-589	15	2	se	se	PROPN
bionys-589	15	3	pokazala	pokazala	PROPN
bionys-589	15	4	kao	kao	PROPN
bionys-589	15	5	veoma	veoma	PROPN
bionys-589	15	6	korisna	korisna	PROPN
bionys-589	15	7	u	u	PROPN
bionys-589	15	8	kontroli	kontroli	PROPN
bionys-589	15	9	oslobađanja	oslobađanja	ADJ
bionys-589	15	10	lekova	lekova	X
bionys-589	15	11	,	,	PUNCT
bionys-589	15	12	čime	čime	PROPN
bionys-589	15	13	se	se	PROPN
bionys-589	15	14	poboljšavaju	poboljšavaju	PROPN
bionys-589	15	15	farmakokinetička	farmakokinetička	NOUN
bionys-589	16	1	i	i	PRON
bionys-589	16	2	farmakodinamička	farmakodinamička	NOUN
bionys-589	16	3	svojstva	svojstva	VERB
bionys-589	16	4	lekovitih	lekovitih	PROPN
bionys-589	16	5	supstanci	supstanci	PROPN
bionys-589	16	6	.	.	PUNCT
bionys-589	17	1	u	u	PROPN
bionys-589	17	2	ovoj	ovoj	PROPN
bionys-589	17	3	studiji	studiji	PROPN
bionys-589	17	4	,	,	PUNCT
bionys-589	17	5	metodom	metodom	NOUN
bionys-589	17	6	desolvatacije	desolvatacije	PROPN
bionys-589	17	7	formirali	formirali	VERB
bionys-589	18	1	smo	smo	PROPN
bionys-589	18	2	nanočestice	nanočestice	PROPN
bionys-589	18	3	napunjene	napunjene	PROPN
bionys-589	18	4	kurkuminom	kurkuminom	PROPN
bionys-589	19	1	i	i	PRON
bionys-589	19	2	amantadinom	amantadinom	NOUN
bionys-589	19	3	,	,	PUNCT
bionys-589	19	4	koristeći	koristeći	VERB
bionys-589	19	5	albumin	albumin	PROPN
bionys-589	19	6	goveđeg	goveđeg	PROPN
bionys-589	19	7	seruma	seruma	PROPN
bionys-589	19	8	(	(	PUNCT
bionys-589	19	9	bsa	bsa	PROPN
bionys-589	19	10	)	)	PUNCT
bionys-589	19	11	kao	kao	PROPN
bionys-589	19	12	nosač	nosač	NOUN
bionys-589	19	13	.	.	PUNCT
bionys-589	20	1	inkapsulacija	inkapsulacija	ADJ
bionys-589	20	2	kurkumina	kurkumina	PROPN
bionys-589	21	1	i	i	PRON
bionys-589	21	2	amantadina	amantadina	PROPN
bionys-589	21	3	doprinela	doprinela	PROPN
bionys-589	21	4	je	je	PROPN
bionys-589	21	5	poboljšanju	poboljšanju	PROPN
bionys-589	21	6	njihove	njihove	VERB
bionys-589	21	7	rastvorljivosti	rastvorljivosti	PROPN
bionys-589	21	8	u	u	PROPN
bionys-589	21	9	vodi	vodi	PROPN
bionys-589	21	10	i	i	PRON
bionys-589	21	11	bioraspoloživost	bioraspoloživost	NOUN
bionys-589	21	12	.	.	PUNCT
bionys-589	22	1	pripremljene	pripremljene	PROPN
bionys-589	22	2	nanočestice	nanočestice	PROPN
bionys-589	22	3	su	su	PROPN
bionys-589	22	4	imale	imale	PROPN
bionys-589	22	5	veličinu	veličinu	NOUN
bionys-589	22	6	čestica	čestica	PROPN
bionys-589	22	7	od	od	ADP
bionys-589	22	8	257	257	NUM
bionys-589	22	9	nm	nm	ADV
bionys-589	23	1	i	i	PRON
bionys-589	23	2	zeta	zeta	VERB
bionys-589	23	3	potencijal	potencijal	PROPN
bionys-589	23	4	od	od	PROPN
bionys-589	23	5	-29	-29	PROPN
bionys-589	23	6	mv	mv	PROPN
bionys-589	23	7	.	.	PROPN
bionys-589	24	1	in	in	ADP
bionys-589	24	2	vitro	vitro	X
bionys-589	24	3	neuroprotektivno	neuroprotektivno	PROPN
bionys-589	24	4	dejstvo	dejstvo	PROPN
bionys-589	24	5	ispitano	ispitano	PROPN
bionys-589	24	6	je	je	PROPN
bionys-589	24	7	na	na	PROPN
bionys-589	24	8	ćelijskim	ćelijskim	PROPN
bionys-589	24	9	linijama	linijama	PROPN
bionys-589	24	10	shsy5y	shsy5y	PROPN
bionys-589	24	11	korišćenjem	korišćenjem	PROPN
bionys-589	24	12	mtt	mtt	PROPN
bionys-589	24	13	testa	testa	PROPN
bionys-589	24	14	,	,	PUNCT
bionys-589	24	15	koji	koji	PROPN
bionys-589	24	16	je	je	PROPN
bionys-589	24	17	pokazao	pokazao	PROPN
bionys-589	24	18	izraženu	izraženu	PROPN
bionys-589	24	19	neuroprotektivnu	neuroprotektivnu	PROPN
bionys-589	24	20	aktivnost	aktivnost	PROPN
bionys-589	24	21	.	.	PUNCT
bionys-589	25	1	ključne	ključne	PROPN
bionys-589	25	2	reči	reči	NOUN
bionys-589	25	3	:	:	PUNCT
bionys-589	25	4	albumin	albumin	PROPN
bionys-589	25	5	goveđeg	goveđeg	PROPN
bionys-589	25	6	seruma	seruma	PROPN
bionys-589	25	7	,	,	PUNCT
bionys-589	25	8	kurkumin	kurkumin	PROPN
bionys-589	25	9	,	,	PUNCT
bionys-589	25	10	amantadin	amantadin	NOUN
bionys-589	25	11	,	,	PUNCT
bionys-589	25	12	desolvatacija	desolvatacija	NOUN
bionys-589	25	13	,	,	PUNCT
bionys-589	25	14	neuroprotektivna	neuroprotektivna	VERB
bionys-589	25	15	aktivnost	aktivnost	ADJ
bionys-589	25	16	introduction	introduction	NOUN
bionys-589	25	17	parkinson	parkinson	NOUN
bionys-589	25	18	’s	’s	PART
bionys-589	25	19	disease	disease	NOUN
bionys-589	25	20	(	(	PUNCT
bionys-589	25	21	pd	pd	NOUN
bionys-589	25	22	)	)	PUNCT
bionys-589	25	23	is	be	AUX
bionys-589	25	24	a	a	DET
bionys-589	25	25	severe	severe	ADJ
bionys-589	25	26	and	and	CCONJ
bionys-589	25	27	debilitating	debilitate	VERB
bionys-589	25	28	neurodegenerative	neurodegenerative	ADJ
bionys-589	25	29	disorder	disorder	NOUN
bionys-589	25	30	that	that	PRON
bionys-589	25	31	predominantly	predominantly	ADV
bionys-589	25	32	affects	affect	VERB
bionys-589	25	33	neurons	neuron	NOUN
bionys-589	25	34	in	in	ADP
bionys-589	25	35	the	the	DET
bionys-589	25	36	brain	brain	NOUN
bionys-589	25	37	.	.	PUNCT
bionys-589	26	1	it	it	PRON
bionys-589	26	2	is	be	AUX
bionys-589	26	3	characterized	characterize	VERB
bionys-589	26	4	by	by	ADP
bionys-589	26	5	the	the	DET
bionys-589	26	6	progressive	progressive	ADJ
bionys-589	26	7	loss	loss	NOUN
bionys-589	26	8	of	of	ADP
bionys-589	26	9	dopaminergic	dopaminergic	ADJ
bionys-589	26	10	neurons	neuron	NOUN
bionys-589	26	11	in	in	ADP
bionys-589	26	12	the	the	DET
bionys-589	26	13	substantia	substantia	NOUN
bionys-589	26	14	nigra	nigra	PROPN
bionys-589	26	15	pars	par	NOUN
bionys-589	26	16	compacta	compacta	NOUN
bionys-589	26	17	(	(	PUNCT
bionys-589	26	18	snpc	snpc	NOUN
bionys-589	26	19	)	)	PUNCT
bionys-589	26	20	,	,	PUNCT
bionys-589	26	21	leading	lead	VERB
bionys-589	26	22	to	to	ADP
bionys-589	26	23	a	a	DET
bionys-589	26	24	deficiency	deficiency	NOUN
bionys-589	26	25	of	of	ADP
bionys-589	26	26	dopamine	dopamine	NOUN
bionys-589	26	27	.	.	PUNCT
bionys-589	27	1	motor	motor	NOUN
bionys-589	27	2	symptoms	symptom	NOUN
bionys-589	27	3	include	include	VERB
bionys-589	27	4	bradykinesia	bradykinesia	PROPN
bionys-589	27	5	,	,	PUNCT
bionys-589	27	6	resting	rest	VERB
bionys-589	27	7	tremors	tremor	NOUN
bionys-589	27	8	,	,	PUNCT
bionys-589	27	9	postural	postural	ADJ
bionys-589	27	10	instability	instability	NOUN
bionys-589	27	11	,	,	PUNCT
bionys-589	27	12	and	and	CCONJ
bionys-589	27	13	muscular	muscular	ADJ
bionys-589	27	14	rigidity	rigidity	NOUN
bionys-589	27	15	.	.	PUNCT
bionys-589	28	1	in	in	ADP
bionys-589	28	2	addition	addition	NOUN
bionys-589	28	3	to	to	ADP
bionys-589	28	4	motor	motor	NOUN
bionys-589	28	5	impairments	impairment	NOUN
bionys-589	28	6	,	,	PUNCT
bionys-589	28	7	non	non	ADJ
bionys-589	28	8	-	-	ADJ
bionys-589	28	9	motor	motor	ADJ
bionys-589	28	10	symptoms	symptom	NOUN
bionys-589	28	11	such	such	ADJ
bionys-589	28	12	as	as	ADP
bionys-589	28	13	dementia	dementia	NOUN
bionys-589	28	14	,	,	PUNCT
bionys-589	28	15	autonomic	autonomic	ADJ
bionys-589	28	16	dysfunction	dysfunction	NOUN
bionys-589	28	17	,	,	PUNCT
bionys-589	28	18	sleep	sleep	NOUN
bionys-589	28	19	disturbances	disturbance	NOUN
bionys-589	28	20	,	,	PUNCT
bionys-589	28	21	sensory	sensory	ADJ
bionys-589	28	22	abnormalities	abnormality	NOUN
bionys-589	28	23	,	,	PUNCT
bionys-589	28	24	depression	depression	NOUN
bionys-589	28	25	,	,	PUNCT
bionys-589	28	26	and	and	CCONJ
bionys-589	28	27	anxiety	anxiety	NOUN
bionys-589	28	28	are	be	AUX
bionys-589	28	29	also	also	ADV
bionys-589	28	30	frequently	frequently	ADV
bionys-589	28	31	observed	observe	VERB
bionys-589	28	32	in	in	ADP
bionys-589	28	33	patients	patient	NOUN
bionys-589	28	34	(	(	PUNCT
bionys-589	28	35	poewe	poewe	NOUN
bionys-589	28	36	et	et	PROPN
bionys-589	28	37	al	al	PROPN
bionys-589	28	38	.	.	PROPN
bionys-589	28	39	,	,	PUNCT
bionys-589	28	40	2017	2017	NUM
bionys-589	28	41	)	)	PUNCT
bionys-589	28	42	.	.	PUNCT
bionys-589	29	1	pd	pd	PROPN
bionys-589	29	2	is	be	AUX
bionys-589	29	3	the	the	DET
bionys-589	29	4	second	second	ADJ
bionys-589	29	5	most	most	ADV
bionys-589	29	6	prevalent	prevalent	ADJ
bionys-589	29	7	neurodegenerative	neurodegenerative	ADJ
bionys-589	29	8	disorder	disorder	NOUN
bionys-589	29	9	after	after	ADP
bionys-589	29	10	alzheimer	alzheimer	PROPN
bionys-589	29	11	’s	’s	PART
bionys-589	29	12	disease	disease	NOUN
bionys-589	29	13	(	(	PUNCT
bionys-589	29	14	ad	ad	NOUN
bionys-589	29	15	)	)	PUNCT
bionys-589	29	16	,	,	PUNCT
bionys-589	29	17	affecting	affect	VERB
bionys-589	29	18	approximately	approximately	ADV
bionys-589	29	19	35	35	NUM
bionys-589	29	20	to	to	PART
bionys-589	29	21	100	100	NUM
bionys-589	29	22	individuals	individual	NOUN
bionys-589	29	23	per	per	ADP
bionys-589	29	24	100,000	100,000	NUM
bionys-589	29	25	people	people	NOUN
bionys-589	29	26	globally	globally	ADV
bionys-589	29	27	(	(	PUNCT
bionys-589	29	28	simon	simon	PROPN
bionys-589	29	29	et	et	PROPN
bionys-589	29	30	al	al	PROPN
bionys-589	29	31	.	.	PROPN
bionys-589	29	32	,	,	PUNCT
bionys-589	29	33	2020	2020	NUM
bionys-589	29	34	)	)	PUNCT
bionys-589	29	35	.	.	PUNCT
bionys-589	30	1	the	the	DET
bionys-589	30	2	worldwide	worldwide	ADJ
bionys-589	30	3	prevalence	prevalence	NOUN
bionys-589	30	4	of	of	ADP
bionys-589	30	5	pd	pd	PROPN
bionys-589	30	6	is	be	AUX
bionys-589	30	7	estimated	estimate	VERB
bionys-589	30	8	at	at	ADP
bionys-589	30	9	7	7	NUM
bionys-589	30	10	to	to	PART
bionys-589	30	11	10	10	NUM
bionys-589	30	12	million	million	NUM
bionys-589	30	13	individuals	individual	NOUN
bionys-589	30	14	,	,	PUNCT
bionys-589	30	15	with	with	ADP
bionys-589	30	16	an	an	DET
bionys-589	30	17	average	average	ADJ
bionys-589	30	18	incidence	incidence	NOUN
bionys-589	30	19	of	of	ADP
bionys-589	30	20	around	around	ADV
bionys-589	30	21	©	©	PROPN
bionys-589	30	22	2025	2025	NUM
bionys-589	30	23	alex	alex	PROPN
bionys-589	30	24	et	et	PROPN
bionys-589	30	25	al	al	PROPN
bionys-589	30	26	.	.	PUNCT
bionys-589	31	1	this	this	PRON
bionys-589	31	2	is	be	AUX
bionys-589	31	3	an	an	DET
bionys-589	31	4	open	open	ADJ
bionys-589	31	5	-	-	PUNCT
bionys-589	31	6	access	access	NOUN
bionys-589	31	7	article	article	NOUN
bionys-589	31	8	distributed	distribute	VERB
bionys-589	31	9	under	under	ADP
bionys-589	31	10	the	the	DET
bionys-589	31	11	terms	term	NOUN
bionys-589	31	12	of	of	ADP
bionys-589	31	13	the	the	DET
bionys-589	31	14	creative	creative	ADJ
bionys-589	31	15	commons	common	NOUN
bionys-589	31	16	attribution	attribution	NOUN
bionys-589	31	17	license	license	NOUN
bionys-589	31	18	,	,	PUNCT
bionys-589	31	19	which	which	PRON
bionys-589	31	20	permits	permit	VERB
bionys-589	31	21	unrestricted	unrestricted	ADJ
bionys-589	31	22	use	use	NOUN
bionys-589	31	23	,	,	PUNCT
bionys-589	31	24	distribution	distribution	NOUN
bionys-589	31	25	,	,	PUNCT
bionys-589	31	26	and	and	CCONJ
bionys-589	31	27	build	build	VERB
bionys-589	31	28	upon	upon	SCONJ
bionys-589	31	29	your	your	PRON
bionys-589	31	30	work	work	NOUN
bionys-589	31	31	non	non	ADJ
bionys-589	31	32	-	-	ADJ
bionys-589	31	33	commercially	commercially	ADV
bionys-589	31	34	under	under	ADP
bionys-589	31	35	the	the	DET
bionys-589	31	36	same	same	ADJ
bionys-589	31	37	license	license	NOUN
bionys-589	31	38	as	as	ADP
bionys-589	31	39	the	the	DET
bionys-589	31	40	original	original	NOUN
bionys-589	31	41	.	.	PUNCT
bionys-589	32	1	268	268	NUM
bionys-589	32	2	41	41	NUM
bionys-589	32	3	per	per	ADP
bionys-589	32	4	100,000	100,000	NUM
bionys-589	32	5	people	people	NOUN
bionys-589	32	6	.	.	PUNCT
bionys-589	33	1	notably	notably	ADV
bionys-589	33	2	,	,	PUNCT
bionys-589	33	3	in	in	ADP
bionys-589	33	4	populations	population	NOUN
bionys-589	33	5	aged	age	VERB
bionys-589	33	6	80	80	NUM
bionys-589	33	7	years	year	NOUN
bionys-589	33	8	and	and	CCONJ
bionys-589	33	9	older	old	ADJ
bionys-589	33	10	,	,	PUNCT
bionys-589	33	11	the	the	DET
bionys-589	33	12	prevalence	prevalence	NOUN
bionys-589	33	13	increases	increase	VERB
bionys-589	33	14	significantly	significantly	ADV
bionys-589	33	15	to	to	ADP
bionys-589	33	16	1,900	1,900	NUM
bionys-589	33	17	per	per	ADP
bionys-589	33	18	100,000	100,000	NUM
bionys-589	33	19	(	(	PUNCT
bionys-589	33	20	parkinson	parkinson	NOUN
bionys-589	33	21	’s	’s	PART
bionys-589	33	22	news	news	NOUN
bionys-589	33	23	today	today	NOUN
bionys-589	33	24	,	,	PUNCT
bionys-589	33	25	2021	2021	NUM
bionys-589	33	26	)	)	PUNCT
bionys-589	33	27	.	.	PUNCT
bionys-589	34	1	projections	projection	NOUN
bionys-589	34	2	suggest	suggest	VERB
bionys-589	34	3	that	that	SCONJ
bionys-589	34	4	this	this	DET
bionys-589	34	5	number	number	NOUN
bionys-589	34	6	will	will	AUX
bionys-589	34	7	rise	rise	VERB
bionys-589	34	8	to	to	ADP
bionys-589	34	9	approximately	approximately	ADV
bionys-589	34	10	12.9	12.9	NUM
bionys-589	34	11	million	million	NUM
bionys-589	34	12	by	by	ADP
bionys-589	34	13	2040	2040	NUM
bionys-589	34	14	(	(	PUNCT
bionys-589	34	15	dorsey	dorsey	PROPN
bionys-589	34	16	et	et	PROPN
bionys-589	34	17	al	al	PROPN
bionys-589	34	18	.	.	PROPN
bionys-589	34	19	,	,	PUNCT
bionys-589	34	20	2018	2018	NUM
bionys-589	34	21	)	)	PUNCT
bionys-589	34	22	.	.	PUNCT
bionys-589	35	1	pd	pd	PROPN
bionys-589	35	2	is	be	AUX
bionys-589	35	3	a	a	DET
bionys-589	35	4	progressive	progressive	ADJ
bionys-589	35	5	and	and	CCONJ
bionys-589	35	6	neurodegenerative	neurodegenerative	ADJ
bionys-589	35	7	disease	disease	NOUN
bionys-589	35	8	first	first	ADV
bionys-589	35	9	systematically	systematically	ADV
bionys-589	35	10	described	describe	VERB
bionys-589	35	11	by	by	ADP
bionys-589	35	12	james	james	PROPN
bionys-589	35	13	parkinson	parkinson	PROPN
bionys-589	35	14	,	,	PUNCT
bionys-589	35	15	who	who	PRON
bionys-589	35	16	referred	refer	VERB
bionys-589	35	17	to	to	ADP
bionys-589	35	18	it	it	PRON
bionys-589	35	19	as	as	ADP
bionys-589	35	20	„	„	PUNCT
bionys-589	35	21	shaking	shake	VERB
bionys-589	35	22	palsy	palsy	ADJ
bionys-589	35	23	”	"	PUNCT
bionys-589	35	24	in	in	ADP
bionys-589	35	25	his	his	PRON
bionys-589	35	26	early	early	ADJ
bionys-589	35	27	observations	observation	NOUN
bionys-589	35	28	(	(	PUNCT
bionys-589	35	29	parkinson	parkinson	NOUN
bionys-589	35	30	,	,	PUNCT
bionys-589	35	31	2002	2002	NUM
bionys-589	35	32	)	)	PUNCT
bionys-589	35	33	.	.	PUNCT
bionys-589	36	1	while	while	SCONJ
bionys-589	36	2	parkinson	parkinson	NOUN
bionys-589	36	3	’s	’s	PART
bionys-589	36	4	terminology	terminology	NOUN
bionys-589	36	5	laid	lay	VERB
bionys-589	36	6	the	the	DET
bionys-589	36	7	groundwork	groundwork	NOUN
bionys-589	36	8	,	,	PUNCT
bionys-589	36	9	subsequent	subsequent	ADJ
bionys-589	36	10	research	research	NOUN
bionys-589	36	11	has	have	AUX
bionys-589	36	12	focused	focus	VERB
bionys-589	36	13	on	on	ADP
bionys-589	36	14	understanding	understand	VERB
bionys-589	36	15	the	the	DET
bionys-589	36	16	clinical	clinical	ADJ
bionys-589	36	17	manifestations	manifestation	NOUN
bionys-589	36	18	and	and	CCONJ
bionys-589	36	19	slowing	slow	VERB
bionys-589	36	20	disease	disease	NOUN
bionys-589	36	21	progression	progression	NOUN
bionys-589	36	22	.	.	PUNCT
bionys-589	37	1	since	since	SCONJ
bionys-589	37	2	the	the	DET
bionys-589	37	3	degeneration	degeneration	NOUN
bionys-589	37	4	of	of	ADP
bionys-589	37	5	dopaminergic	dopaminergic	ADJ
bionys-589	37	6	neurons	neuron	NOUN
bionys-589	37	7	can	can	AUX
bionys-589	37	8	not	not	PART
bionys-589	37	9	currently	currently	ADV
bionys-589	37	10	be	be	AUX
bionys-589	37	11	halted	halt	VERB
bionys-589	37	12	or	or	CCONJ
bionys-589	37	13	reversed	reverse	VERB
bionys-589	37	14	,	,	PUNCT
bionys-589	37	15	existing	exist	VERB
bionys-589	37	16	treatments	treatment	NOUN
bionys-589	37	17	for	for	ADP
bionys-589	37	18	pd	pd	PROPN
bionys-589	37	19	primarily	primarily	ADV
bionys-589	37	20	aim	aim	VERB
bionys-589	37	21	to	to	PART
bionys-589	37	22	alleviate	alleviate	VERB
bionys-589	37	23	both	both	DET
bionys-589	37	24	motor	motor	NOUN
bionys-589	37	25	and	and	CCONJ
bionys-589	37	26	non	non	ADJ
bionys-589	37	27	-	-	ADJ
bionys-589	37	28	motor	motor	ADJ
bionys-589	37	29	symptoms	symptom	NOUN
bionys-589	37	30	.	.	PUNCT
bionys-589	38	1	a	a	DET
bionys-589	38	2	major	major	ADJ
bionys-589	38	3	limitation	limitation	NOUN
bionys-589	38	4	of	of	ADP
bionys-589	38	5	current	current	ADJ
bionys-589	38	6	pharmacological	pharmacological	ADJ
bionys-589	38	7	therapies	therapy	NOUN
bionys-589	38	8	is	be	AUX
bionys-589	38	9	their	their	PRON
bionys-589	38	10	restricted	restrict	VERB
bionys-589	38	11	ability	ability	NOUN
bionys-589	38	12	to	to	PART
bionys-589	38	13	cross	cross	VERB
bionys-589	38	14	the	the	DET
bionys-589	38	15	blood	blood	NOUN
bionys-589	38	16	-	-	PUNCT
bionys-589	38	17	brain	brain	NOUN
bionys-589	38	18	barrier	barrier	NOUN
bionys-589	38	19	(	(	PUNCT
bionys-589	38	20	bbb	bbb	PROPN
bionys-589	38	21	)	)	PUNCT
bionys-589	38	22	,	,	PUNCT
bionys-589	38	23	which	which	PRON
bionys-589	38	24	limits	limit	VERB
bionys-589	38	25	central	central	ADJ
bionys-589	38	26	nervous	nervous	ADJ
bionys-589	38	27	system	system	NOUN
bionys-589	38	28	localization	localization	NOUN
bionys-589	38	29	and	and	CCONJ
bionys-589	38	30	often	often	ADV
bionys-589	38	31	necessitates	necessitate	VERB
bionys-589	38	32	low	low	ADJ
bionys-589	38	33	-	-	PUNCT
bionys-589	38	34	dose	dose	NOUN
bionys-589	38	35	administrations	administration	NOUN
bionys-589	38	36	(	(	PUNCT
bionys-589	38	37	tonda	tonda	PROPN
bionys-589	38	38	et	et	PROPN
bionys-589	38	39	al	al	PROPN
bionys-589	38	40	.	.	PROPN
bionys-589	38	41	,	,	PUNCT
bionys-589	38	42	2018	2018	NUM
bionys-589	38	43	)	)	PUNCT
bionys-589	38	44	.	.	PUNCT
bionys-589	39	1	many	many	ADJ
bionys-589	39	2	treatments	treatment	NOUN
bionys-589	39	3	also	also	ADV
bionys-589	39	4	suffer	suffer	VERB
bionys-589	39	5	from	from	ADP
bionys-589	39	6	issues	issue	NOUN
bionys-589	39	7	such	such	ADJ
bionys-589	39	8	as	as	ADP
bionys-589	39	9	low	low	ADJ
bionys-589	39	10	stability	stability	NOUN
bionys-589	39	11	,	,	PUNCT
bionys-589	39	12	potential	potential	ADJ
bionys-589	39	13	toxicity	toxicity	NOUN
bionys-589	39	14	of	of	ADP
bionys-589	39	15	degradation	degradation	NOUN
bionys-589	39	16	by	by	ADP
bionys-589	39	17	-	-	PUNCT
bionys-589	39	18	products	product	NOUN
bionys-589	39	19	,	,	PUNCT
bionys-589	39	20	high	high	ADJ
bionys-589	39	21	production	production	NOUN
bionys-589	39	22	costs	cost	NOUN
bionys-589	39	23	,	,	PUNCT
bionys-589	39	24	and	and	CCONJ
bionys-589	39	25	limited	limited	ADJ
bionys-589	39	26	neuroprotective	neuroprotective	ADJ
bionys-589	39	27	efficacy	efficacy	NOUN
bionys-589	39	28	—	—	PUNCT
bionys-589	39	29	highlighting	highlight	VERB
bionys-589	39	30	the	the	DET
bionys-589	39	31	need	need	NOUN
bionys-589	39	32	for	for	ADP
bionys-589	39	33	further	further	ADJ
bionys-589	39	34	research	research	NOUN
bionys-589	39	35	.	.	PUNCT
bionys-589	40	1	consequently	consequently	ADV
bionys-589	40	2	,	,	PUNCT
bionys-589	40	3	there	there	PRON
bionys-589	40	4	is	be	VERB
bionys-589	40	5	a	a	DET
bionys-589	40	6	pressing	press	VERB
bionys-589	40	7	need	need	NOUN
bionys-589	40	8	for	for	ADP
bionys-589	40	9	the	the	DET
bionys-589	40	10	development	development	NOUN
bionys-589	40	11	of	of	ADP
bionys-589	40	12	novel	novel	ADJ
bionys-589	40	13	drug	drug	NOUN
bionys-589	40	14	delivery	delivery	NOUN
bionys-589	40	15	systems	system	NOUN
bionys-589	40	16	that	that	PRON
bionys-589	40	17	can	can	AUX
bionys-589	40	18	prolong	prolong	VERB
bionys-589	40	19	and	and	CCONJ
bionys-589	40	20	regulate	regulate	VERB
bionys-589	40	21	drug	drug	NOUN
bionys-589	40	22	release	release	NOUN
bionys-589	40	23	.	.	PUNCT
bionys-589	41	1	emerging	emerge	VERB
bionys-589	41	2	trends	trend	NOUN
bionys-589	41	3	in	in	ADP
bionys-589	41	4	nanotechnology	nanotechnology	NOUN
bionys-589	41	5	have	have	AUX
bionys-589	41	6	demonstrated	demonstrate	VERB
bionys-589	41	7	that	that	SCONJ
bionys-589	41	8	nanoparticles	nanoparticle	NOUN
bionys-589	41	9	(	(	PUNCT
bionys-589	41	10	nps	nps	PROPN
bionys-589	41	11	)	)	PUNCT
bionys-589	41	12	can	can	AUX
bionys-589	41	13	enhance	enhance	VERB
bionys-589	41	14	drug	drug	NOUN
bionys-589	41	15	delivery	delivery	NOUN
bionys-589	41	16	by	by	ADP
bionys-589	41	17	improving	improve	VERB
bionys-589	41	18	cellular	cellular	ADJ
bionys-589	41	19	uptake	uptake	NOUN
bionys-589	41	20	,	,	PUNCT
bionys-589	41	21	reducing	reduce	VERB
bionys-589	41	22	issues	issue	NOUN
bionys-589	41	23	of	of	ADP
bionys-589	41	24	low	low	ADJ
bionys-589	41	25	bioavailability	bioavailability	NOUN
bionys-589	41	26	,	,	PUNCT
bionys-589	41	27	minimizing	minimize	VERB
bionys-589	41	28	pharmacokinetic	pharmacokinetic	ADJ
bionys-589	41	29	side	side	NOUN
bionys-589	41	30	effects	effect	NOUN
bionys-589	41	31	,	,	PUNCT
bionys-589	41	32	reducing	reduce	VERB
bionys-589	41	33	the	the	DET
bionys-589	41	34	dosing	dosing	ADJ
bionys-589	41	35	frequency	frequency	NOUN
bionys-589	41	36	,	,	PUNCT
bionys-589	41	37	and	and	CCONJ
bionys-589	41	38	increasing	increase	VERB
bionys-589	41	39	drug	drug	NOUN
bionys-589	41	40	concentration	concentration	NOUN
bionys-589	41	41	in	in	ADP
bionys-589	41	42	targeted	target	VERB
bionys-589	41	43	brain	brain	NOUN
bionys-589	41	44	regions	region	NOUN
bionys-589	41	45	(	(	PUNCT
bionys-589	41	46	alonso	alonso	PROPN
bionys-589	41	47	et	et	NOUN
bionys-589	41	48	al	al	PROPN
bionys-589	41	49	.	.	PROPN
bionys-589	41	50	,	,	PUNCT
bionys-589	41	51	2012	2012	NUM
bionys-589	41	52	;	;	PUNCT
bionys-589	41	53	yadav	yadav	PROPN
bionys-589	41	54	et	et	PROPN
bionys-589	41	55	al	al	PROPN
bionys-589	41	56	.	.	PROPN
bionys-589	41	57	,	,	PUNCT
bionys-589	41	58	2025	2025	NUM
bionys-589	41	59	)	)	PUNCT
bionys-589	41	60	.	.	PUNCT
bionys-589	42	1	among	among	ADP
bionys-589	42	2	these	these	DET
bionys-589	42	3	,	,	PUNCT
bionys-589	42	4	controlled	control	VERB
bionys-589	42	5	drug	drug	NOUN
bionys-589	42	6	release	release	NOUN
bionys-589	42	7	systems	system	NOUN
bionys-589	42	8	are	be	AUX
bionys-589	42	9	particularly	particularly	ADV
bionys-589	42	10	promising	promising	ADJ
bionys-589	42	11	due	due	ADP
bionys-589	42	12	to	to	ADP
bionys-589	42	13	their	their	PRON
bionys-589	42	14	simplicity	simplicity	NOUN
bionys-589	42	15	,	,	PUNCT
bionys-589	42	16	reproducibility	reproducibility	NOUN
bionys-589	42	17	,	,	PUNCT
bionys-589	42	18	and	and	CCONJ
bionys-589	42	19	effectiveness	effectiveness	NOUN
bionys-589	42	20	.	.	PUNCT
bionys-589	43	1	nanotechnologyassisted	nanotechnologyassiste	VERB
bionys-589	43	2	delivery	delivery	NOUN
bionys-589	43	3	can	can	AUX
bionys-589	43	4	significantly	significantly	ADV
bionys-589	43	5	enhance	enhance	VERB
bionys-589	43	6	both	both	CCONJ
bionys-589	43	7	the	the	DET
bionys-589	43	8	pharmacokinetic	pharmacokinetic	ADJ
bionys-589	43	9	and	and	CCONJ
bionys-589	43	10	pharmacodynamic	pharmacodynamic	ADJ
bionys-589	43	11	profiles	profile	NOUN
bionys-589	43	12	of	of	ADP
bionys-589	43	13	therapeutic	therapeutic	ADJ
bionys-589	43	14	agents	agent	NOUN
bionys-589	43	15	.	.	PUNCT
bionys-589	44	1	curcumin	curcumin	NOUN
bionys-589	44	2	,	,	PUNCT
bionys-589	44	3	a	a	DET
bionys-589	44	4	well	well	ADV
bionys-589	44	5	-	-	PUNCT
bionys-589	44	6	known	know	VERB
bionys-589	44	7	polyphenolic	polyphenolic	NOUN
bionys-589	44	8	compound	compound	NOUN
bionys-589	44	9	with	with	ADP
bionys-589	44	10	broad	broad	ADJ
bionys-589	44	11	pharmacological	pharmacological	ADJ
bionys-589	44	12	activity	activity	NOUN
bionys-589	44	13	(	(	PUNCT
bionys-589	44	14	gayathri	gayathri	PROPN
bionys-589	44	15	et	et	PROPN
bionys-589	44	16	al	al	PROPN
bionys-589	44	17	.	.	PROPN
bionys-589	44	18	,	,	PUNCT
bionys-589	44	19	2023	2023	NUM
bionys-589	44	20	)	)	PUNCT
bionys-589	44	21	,	,	PUNCT
bionys-589	44	22	exhibits	exhibit	VERB
bionys-589	44	23	notable	notable	ADJ
bionys-589	44	24	neuroprotective	neuroprotective	ADJ
bionys-589	44	25	effects	effect	NOUN
bionys-589	44	26	(	(	PUNCT
bionys-589	44	27	tsai	tsai	PROPN
bionys-589	44	28	et	et	PROPN
bionys-589	44	29	al	al	PROPN
bionys-589	44	30	.	.	PROPN
bionys-589	44	31	,	,	PUNCT
bionys-589	44	32	2011	2011	NUM
bionys-589	44	33	;	;	PUNCT
bionys-589	44	34	nair	nair	PROPN
bionys-589	44	35	et	et	PROPN
bionys-589	44	36	al	al	PROPN
bionys-589	44	37	.	.	PROPN
bionys-589	44	38	,	,	PUNCT
bionys-589	44	39	2014	2014	NUM
bionys-589	44	40	)	)	PUNCT
bionys-589	44	41	.	.	PUNCT
bionys-589	45	1	its	its	PRON
bionys-589	45	2	mechanisms	mechanism	NOUN
bionys-589	45	3	of	of	ADP
bionys-589	45	4	neuroprotection	neuroprotection	NOUN
bionys-589	45	5	may	may	AUX
bionys-589	45	6	include	include	VERB
bionys-589	45	7	inhibition	inhibition	NOUN
bionys-589	45	8	of	of	ADP
bionys-589	45	9	reactive	reactive	ADJ
bionys-589	45	10	oxygen	oxygen	NOUN
bionys-589	45	11	species	specie	NOUN
bionys-589	45	12	(	(	PUNCT
bionys-589	45	13	ros	ros	PROPN
bionys-589	45	14	)	)	PUNCT
bionys-589	45	15	production	production	NOUN
bionys-589	45	16	due	due	ADP
bionys-589	45	17	to	to	ADP
bionys-589	45	18	its	its	PRON
bionys-589	45	19	potent	potent	ADJ
bionys-589	45	20	antioxidant	antioxidant	NOUN
bionys-589	45	21	and	and	CCONJ
bionys-589	45	22	anti	anti	ADJ
bionys-589	45	23	-	-	ADJ
bionys-589	45	24	inflammatory	inflammatory	ADJ
bionys-589	45	25	properties	property	NOUN
bionys-589	45	26	.	.	PUNCT
bionys-589	46	1	curcumin	curcumin	NOUN
bionys-589	46	2	also	also	ADV
bionys-589	46	3	affects	affect	VERB
bionys-589	46	4	glial	glial	ADJ
bionys-589	46	5	cell	cell	NOUN
bionys-589	46	6	function	function	NOUN
bionys-589	46	7	,	,	PUNCT
bionys-589	46	8	α	α	X
bionys-589	46	9	-	-	PUNCT
bionys-589	46	10	synuclein	synuclein	NOUN
bionys-589	46	11	aggregation	aggregation	NOUN
bionys-589	46	12	,	,	PUNCT
bionys-589	46	13	neuronal	neuronal	ADJ
bionys-589	46	14	apoptosis	apoptosis	NOUN
bionys-589	46	15	,	,	PUNCT
bionys-589	46	16	and	and	CCONJ
bionys-589	46	17	ferroptosis	ferroptosis	NOUN
bionys-589	46	18	.	.	PUNCT
bionys-589	47	1	however	however	ADV
bionys-589	47	2	,	,	PUNCT
bionys-589	47	3	clinical	clinical	ADJ
bionys-589	47	4	application	application	NOUN
bionys-589	47	5	is	be	AUX
bionys-589	47	6	limited	limit	VERB
bionys-589	47	7	by	by	ADP
bionys-589	47	8	its	its	PRON
bionys-589	47	9	poor	poor	ADJ
bionys-589	47	10	oral	oral	ADJ
bionys-589	47	11	bioavailability	bioavailability	NOUN
bionys-589	47	12	and	and	CCONJ
bionys-589	47	13	low	low	ADJ
bionys-589	47	14	solubility	solubility	NOUN
bionys-589	47	15	(	(	PUNCT
bionys-589	47	16	young	young	PROPN
bionys-589	47	17	et	et	PROPN
bionys-589	47	18	al	al	PROPN
bionys-589	47	19	.	.	PROPN
bionys-589	47	20	,	,	PUNCT
bionys-589	47	21	2014	2014	NUM
bionys-589	47	22	)	)	PUNCT
bionys-589	47	23	.	.	PUNCT
bionys-589	48	1	these	these	DET
bionys-589	48	2	challenges	challenge	NOUN
bionys-589	48	3	may	may	AUX
bionys-589	48	4	be	be	AUX
bionys-589	48	5	mitigated	mitigate	VERB
bionys-589	48	6	through	through	ADP
bionys-589	48	7	nano	nano	NOUN
bionys-589	48	8	-	-	PUNCT
bionys-589	48	9	based	base	VERB
bionys-589	48	10	drug	drug	NOUN
bionys-589	48	11	delivery	delivery	NOUN
bionys-589	48	12	systems	system	NOUN
bionys-589	48	13	(	(	PUNCT
bionys-589	48	14	takahashi	takahashi	PROPN
bionys-589	48	15	et	et	PROPN
bionys-589	48	16	al	al	PROPN
bionys-589	48	17	.	.	PROPN
bionys-589	48	18	,	,	PUNCT
bionys-589	48	19	2009	2009	NUM
bionys-589	48	20	;	;	PUNCT
bionys-589	49	1	cheng	cheng	PROPN
bionys-589	49	2	et	et	PROPN
bionys-589	49	3	al	al	PROPN
bionys-589	49	4	.	.	PROPN
bionys-589	49	5	,	,	PUNCT
bionys-589	49	6	2013	2013	NUM
bionys-589	49	7	;	;	PUNCT
bionys-589	49	8	mourtas	mourta	NOUN
bionys-589	49	9	et	et	NOUN
bionys-589	49	10	al	al	PROPN
bionys-589	49	11	.	.	PROPN
bionys-589	49	12	,	,	PUNCT
bionys-589	49	13	2014	2014	NUM
bionys-589	49	14	)	)	PUNCT
bionys-589	49	15	.	.	PUNCT
bionys-589	50	1	studies	study	NOUN
bionys-589	50	2	in	in	ADP
bionys-589	50	3	drosophila	drosophila	NOUN
bionys-589	50	4	models	model	NOUN
bionys-589	50	5	of	of	ADP
bionys-589	50	6	pd	pd	PROPN
bionys-589	50	7	have	have	AUX
bionys-589	50	8	shown	show	VERB
bionys-589	50	9	that	that	SCONJ
bionys-589	50	10	nanocurcumin	nanocurcumin	PROPN
bionys-589	50	11	significantly	significantly	ADV
bionys-589	50	12	reduces	reduce	VERB
bionys-589	50	13	pd	pd	NOUN
bionys-589	50	14	symptoms	symptom	NOUN
bionys-589	50	15	,	,	PUNCT
bionys-589	50	16	and	and	CCONJ
bionys-589	50	17	it	it	PRON
bionys-589	50	18	demonstrates	demonstrate	VERB
bionys-589	50	19	higher	high	ADJ
bionys-589	50	20	bioavailability	bioavailability	NOUN
bionys-589	50	21	and	and	CCONJ
bionys-589	50	22	neuroprotective	neuroprotective	ADJ
bionys-589	50	23	activity	activity	NOUN
bionys-589	50	24	in	in	ADP
bionys-589	50	25	murine	murine	ADJ
bionys-589	50	26	brains	brain	NOUN
bionys-589	50	27	compared	compare	VERB
bionys-589	50	28	to	to	ADP
bionys-589	50	29	conventional	conventional	ADJ
bionys-589	50	30	curcumin	curcumin	NOUN
bionys-589	50	31	(	(	PUNCT
bionys-589	50	32	nazari	nazari	NOUN
bionys-589	50	33	et	et	PROPN
bionys-589	50	34	al	al	PROPN
bionys-589	50	35	.	.	PROPN
bionys-589	50	36	,	,	PUNCT
bionys-589	50	37	2014	2014	NUM
bionys-589	50	38	)	)	PUNCT
bionys-589	50	39	.	.	PUNCT
bionys-589	51	1	amantadine	amantadine	PROPN
bionys-589	51	2	originally	originally	ADV
bionys-589	51	3	approved	approve	VERB
bionys-589	51	4	as	as	ADP
bionys-589	51	5	an	an	DET
bionys-589	51	6	antiviral	antiviral	ADJ
bionys-589	51	7	agent	agent	NOUN
bionys-589	51	8	for	for	ADP
bionys-589	51	9	influenza	influenza	NOUN
bionys-589	51	10	a	a	DET
bionys-589	51	11	(	(	PUNCT
bionys-589	51	12	staničová	staničová	X
bionys-589	51	13	et	et	PROPN
bionys-589	51	14	al	al	PROPN
bionys-589	51	15	.	.	PROPN
bionys-589	51	16	,	,	PUNCT
bionys-589	51	17	2001	2001	NUM
bionys-589	51	18	)	)	PUNCT
bionys-589	51	19	,	,	PUNCT
bionys-589	51	20	has	have	AUX
bionys-589	51	21	demonstrated	demonstrate	VERB
bionys-589	51	22	antiviral	antiviral	ADJ
bionys-589	51	23	activity	activity	NOUN
bionys-589	51	24	against	against	ADP
bionys-589	51	25	sarscov-2	sarscov-2	NUM
bionys-589	51	26	(	(	PUNCT
bionys-589	51	27	rascol	rascol	NOUN
bionys-589	51	28	et	et	PROPN
bionys-589	51	29	al	al	PROPN
bionys-589	51	30	.	.	PROPN
bionys-589	51	31	,	,	PUNCT
bionys-589	51	32	2021	2021	NUM
bionys-589	51	33	)	)	PUNCT
bionys-589	51	34	and	and	CCONJ
bionys-589	51	35	anti	anti	ADJ
bionys-589	51	36	-	-	ADJ
bionys-589	51	37	parkinsonian	parkinsonian	ADJ
bionys-589	51	38	properties	property	NOUN
bionys-589	51	39	(	(	PUNCT
bionys-589	51	40	maksymiuk	maksymiuk	NOUN
bionys-589	51	41	et	et	NOUN
bionys-589	51	42	al	al	PROPN
bionys-589	51	43	.	.	PROPN
bionys-589	51	44	,	,	PUNCT
bionys-589	51	45	2021	2021	NUM
bionys-589	51	46	;	;	PUNCT
bionys-589	51	47	espay	espay	X
bionys-589	51	48	et	et	PROPN
bionys-589	51	49	al	al	PROPN
bionys-589	51	50	.	.	PROPN
bionys-589	51	51	,	,	PUNCT
bionys-589	51	52	2024	2024	NUM
bionys-589	51	53	)	)	PUNCT
bionys-589	51	54	.	.	PUNCT
bionys-589	52	1	it	it	PRON
bionys-589	52	2	has	have	AUX
bionys-589	52	3	also	also	ADV
bionys-589	52	4	shown	show	VERB
bionys-589	52	5	antiproliferative	antiproliferative	ADJ
bionys-589	52	6	effects	effect	NOUN
bionys-589	52	7	in	in	ADP
bionys-589	52	8	various	various	ADJ
bionys-589	52	9	melanoma	melanoma	NOUN
bionys-589	52	10	cell	cell	NOUN
bionys-589	52	11	lines	line	NOUN
bionys-589	52	12	.	.	PUNCT
bionys-589	53	1	this	this	DET
bionys-589	53	2	study	study	NOUN
bionys-589	53	3	aims	aim	VERB
bionys-589	53	4	to	to	PART
bionys-589	53	5	develop	develop	VERB
bionys-589	53	6	and	and	CCONJ
bionys-589	53	7	evaluate	evaluate	VERB
bionys-589	53	8	nanoparticles	nanoparticle	NOUN
bionys-589	53	9	co	co	VERB
bionys-589	53	10	-	-	VERB
bionys-589	53	11	loaded	load	VERB
bionys-589	53	12	with	with	ADP
bionys-589	53	13	curcumin	curcumin	NOUN
bionys-589	53	14	and	and	CCONJ
bionys-589	53	15	amantadine	amantadine	NOUN
bionys-589	53	16	for	for	ADP
bionys-589	53	17	their	their	PRON
bionys-589	53	18	neuroprotective	neuroprotective	ADJ
bionys-589	53	19	potential	potential	NOUN
bionys-589	53	20	in	in	ADP
bionys-589	53	21	parkinson	parkinson	NOUN
bionys-589	53	22	’s	’s	PART
bionys-589	53	23	disease	disease	NOUN
bionys-589	53	24	.	.	PUNCT
bionys-589	54	1	the	the	DET
bionys-589	54	2	combination	combination	NOUN
bionys-589	54	3	of	of	ADP
bionys-589	54	4	curcumin	curcumin	NOUN
bionys-589	54	5	and	and	CCONJ
bionys-589	54	6	amantadine	amantadine	NOUN
bionys-589	54	7	within	within	ADP
bionys-589	54	8	a	a	DET
bionys-589	54	9	nanoparticle	nanoparticle	NOUN
bionys-589	54	10	formulation	formulation	NOUN
bionys-589	54	11	may	may	AUX
bionys-589	54	12	produce	produce	VERB
bionys-589	54	13	increased	increase	VERB
bionys-589	54	14	therapeutic	therapeutic	ADJ
bionys-589	54	15	effects	effect	NOUN
bionys-589	54	16	,	,	PUNCT
bionys-589	54	17	enhancing	enhance	VERB
bionys-589	54	18	their	their	PRON
bionys-589	54	19	individual	individual	ADJ
bionys-589	54	20	benefits	benefit	NOUN
bionys-589	54	21	while	while	SCONJ
bionys-589	54	22	reducing	reduce	VERB
bionys-589	54	23	side	side	NOUN
bionys-589	54	24	effects	effect	NOUN
bionys-589	54	25	.	.	PUNCT
bionys-589	55	1	improving	improve	VERB
bionys-589	55	2	bbb	bbb	NOUN
bionys-589	55	3	penetration	penetration	NOUN
bionys-589	55	4	and	and	CCONJ
bionys-589	55	5	bioavailability	bioavailability	NOUN
bionys-589	55	6	through	through	ADP
bionys-589	55	7	nanocarrier	nanocarrier	NOUN
bionys-589	55	8	systems	system	NOUN
bionys-589	55	9	can	can	AUX
bionys-589	55	10	help	help	VERB
bionys-589	55	11	achieve	achieve	VERB
bionys-589	55	12	sustained	sustained	ADJ
bionys-589	55	13	drug	drug	NOUN
bionys-589	55	14	release	release	NOUN
bionys-589	55	15	,	,	PUNCT
bionys-589	55	16	prolonged	prolong	VERB
bionys-589	55	17	therapeutic	therapeutic	ADJ
bionys-589	55	18	action	action	NOUN
bionys-589	55	19	,	,	PUNCT
bionys-589	55	20	and	and	CCONJ
bionys-589	55	21	reduced	reduce	VERB
bionys-589	55	22	dosing	dose	VERB
bionys-589	55	23	frequency	frequency	NOUN
bionys-589	55	24	.	.	PUNCT
bionys-589	56	1	materials	material	NOUN
bionys-589	56	2	and	and	CCONJ
bionys-589	56	3	methods	method	NOUN
bionys-589	56	4	amantadine	amantadine	NOUN
bionys-589	56	5	and	and	CCONJ
bionys-589	56	6	curcumin	curcumin	NOUN
bionys-589	56	7	were	be	AUX
bionys-589	56	8	purchased	purchase	VERB
bionys-589	56	9	from	from	ADP
bionys-589	56	10	yarrow	yarrow	NOUN
bionys-589	56	11	chem	chem	NOUN
bionys-589	56	12	products	product	NOUN
bionys-589	56	13	(	(	PUNCT
bionys-589	56	14	mumbai	mumbai	PROPN
bionys-589	56	15	)	)	PUNCT
bionys-589	56	16	,	,	PUNCT
bionys-589	56	17	bovine	bovine	NOUN
bionys-589	56	18	serum	serum	NOUN
bionys-589	56	19	albumine	albumine	PROPN
bionys-589	56	20	(	(	PUNCT
bionys-589	56	21	bsa	bsa	PROPN
bionys-589	56	22	)	)	PUNCT
bionys-589	56	23	from	from	ADP
bionys-589	56	24	sigma	sigma	NOUN
bionys-589	56	25	,	,	PUNCT
bionys-589	56	26	and	and	CCONJ
bionys-589	56	27	ethanol	ethanol	NOUN
bionys-589	56	28	and	and	CCONJ
bionys-589	56	29	glutaraldehyde	glutaraldehyde	NOUN
bionys-589	56	30	from	from	ADP
bionys-589	56	31	nice	nice	ADJ
bionys-589	56	32	chemicals	chemical	NOUN
bionys-589	56	33	pvt	pvt	PROPN
bionys-589	56	34	ltd	ltd	PROPN
bionys-589	56	35	(	(	PUNCT
bionys-589	56	36	kochi	kochi	PROPN
bionys-589	56	37	)	)	PUNCT
bionys-589	56	38	.	.	PUNCT
bionys-589	57	1	preparation	preparation	NOUN
bionys-589	57	2	of	of	ADP
bionys-589	57	3	albumin	albumin	ADJ
bionys-589	57	4	nanoparticles	nanoparticle	NOUN
bionys-589	57	5	desolvation	desolvation	NOUN
bionys-589	57	6	involves	involve	VERB
bionys-589	57	7	the	the	DET
bionys-589	57	8	addition	addition	NOUN
bionys-589	57	9	of	of	ADP
bionys-589	57	10	organic	organic	ADJ
bionys-589	57	11	solvents	solvent	NOUN
bionys-589	57	12	to	to	ADP
bionys-589	57	13	an	an	DET
bionys-589	57	14	aqueous	aqueous	ADJ
bionys-589	57	15	solution	solution	NOUN
bionys-589	57	16	of	of	ADP
bionys-589	57	17	albumin	albumin	NOUN
bionys-589	57	18	,	,	PUNCT
bionys-589	57	19	followed	follow	VERB
bionys-589	57	20	by	by	ADP
bionys-589	57	21	chemical	chemical	PROPN
bionys-589	57	22	cross	cross	PROPN
bionys-589	57	23	-	-	ADJ
bionys-589	57	24	linking	link	VERB
bionys-589	57	25	with	with	ADP
bionys-589	57	26	glutaraldehyde	glutaraldehyde	NOUN
bionys-589	57	27	.	.	PUNCT
bionys-589	58	1	the	the	DET
bionys-589	58	2	required	require	VERB
bionys-589	58	3	amount	amount	NOUN
bionys-589	58	4	of	of	ADP
bionys-589	58	5	lyophilized	lyophilized	ADJ
bionys-589	58	6	bsa	bsa	PROPN
bionys-589	58	7	powder	powder	NOUN
bionys-589	58	8	was	be	AUX
bionys-589	58	9	dissolved	dissolve	VERB
bionys-589	58	10	in	in	ADP
bionys-589	58	11	distilled	distil	VERB
bionys-589	58	12	water	water	NOUN
bionys-589	58	13	to	to	PART
bionys-589	58	14	make	make	VERB
bionys-589	58	15	a	a	DET
bionys-589	58	16	bsa	bsa	NOUN
bionys-589	58	17	solution	solution	NOUN
bionys-589	58	18	.	.	PUNCT
bionys-589	59	1	the	the	DET
bionys-589	59	2	drug	drug	NOUN
bionys-589	59	3	was	be	AUX
bionys-589	59	4	dissolved	dissolve	VERB
bionys-589	59	5	in	in	ADP
bionys-589	59	6	either	either	CCONJ
bionys-589	59	7	ethanol	ethanol	NOUN
bionys-589	59	8	or	or	CCONJ
bionys-589	59	9	acetone	acetone	NOUN
bionys-589	59	10	separately	separately	ADV
bionys-589	59	11	.	.	PUNCT
bionys-589	60	1	the	the	DET
bionys-589	60	2	ph	ph	PROPN
bionys-589	60	3	was	be	AUX
bionys-589	60	4	adjusted	adjust	VERB
bionys-589	60	5	to	to	ADP
bionys-589	60	6	between	between	ADP
bionys-589	60	7	7	7	NUM
bionys-589	60	8	and	and	CCONJ
bionys-589	60	9	8	8	NUM
bionys-589	60	10	.	.	PUNCT
bionys-589	61	1	a	a	DET
bionys-589	61	2	magnetic	magnetic	ADJ
bionys-589	61	3	stirrer	stirrer	NOUN
bionys-589	61	4	at	at	ADP
bionys-589	61	5	500	500	NUM
bionys-589	61	6	rpm	rpm	NOUN
bionys-589	61	7	was	be	AUX
bionys-589	61	8	used	use	VERB
bionys-589	61	9	for	for	ADP
bionys-589	61	10	stirring	stir	VERB
bionys-589	61	11	until	until	SCONJ
bionys-589	61	12	turbidity	turbidity	NOUN
bionys-589	61	13	was	be	AUX
bionys-589	61	14	observed	observe	VERB
bionys-589	61	15	by	by	ADP
bionys-589	61	16	adding	add	VERB
bionys-589	61	17	ethanol	ethanol	NOUN
bionys-589	61	18	at	at	ADP
bionys-589	61	19	a	a	DET
bionys-589	61	20	1	1	NUM
bionys-589	61	21	ml	ml	NOUN
bionys-589	61	22	/	/	SYM
bionys-589	61	23	min	min	NOUN
bionys-589	61	24	rate	rate	NOUN
bionys-589	61	25	.	.	PUNCT
bionys-589	62	1	glutaraldehyde	glutaraldehyde	NOUN
bionys-589	62	2	was	be	AUX
bionys-589	62	3	then	then	ADV
bionys-589	62	4	added	add	VERB
bionys-589	62	5	for	for	ADP
bionys-589	62	6	cross	cross	NOUN
bionys-589	62	7	-	-	ADJ
bionys-589	62	8	linking	link	VERB
bionys-589	62	9	the	the	DET
bionys-589	62	10	bsa	bsa	PROPN
bionys-589	62	11	nanoparticles	nanoparticle	NOUN
bionys-589	62	12	.	.	PUNCT
bionys-589	63	1	specifically	specifically	ADV
bionys-589	63	2	,	,	PUNCT
bionys-589	63	3	0.1	0.1	NUM
bionys-589	63	4	ml	ml	NOUN
bionys-589	63	5	of	of	ADP
bionys-589	63	6	4	4	NUM
bionys-589	63	7	%	%	NOUN
bionys-589	63	8	glutaraldehyde	glutaraldehyde	NOUN
bionys-589	63	9	solution	solution	NOUN
bionys-589	63	10	was	be	AUX
bionys-589	63	11	added	add	VERB
bionys-589	63	12	,	,	PUNCT
bionys-589	63	13	and	and	CCONJ
bionys-589	63	14	the	the	DET
bionys-589	63	15	mixture	mixture	NOUN
bionys-589	63	16	was	be	AUX
bionys-589	63	17	stirred	stir	VERB
bionys-589	63	18	for	for	ADP
bionys-589	63	19	2	2	NUM
bionys-589	63	20	hours	hour	NOUN
bionys-589	63	21	.	.	PUNCT
bionys-589	64	1	the	the	DET
bionys-589	64	2	stirring	stir	VERB
bionys-589	64	3	process	process	NOUN
bionys-589	64	4	was	be	AUX
bionys-589	64	5	continued	continue	VERB
bionys-589	64	6	for	for	ADP
bionys-589	64	7	24	24	NUM
bionys-589	64	8	h	h	NOUN
bionys-589	64	9	,	,	PUNCT
bionys-589	64	10	followed	follow	VERB
bionys-589	64	11	by	by	ADP
bionys-589	64	12	five	five	NUM
bionys-589	64	13	cycles	cycle	NOUN
bionys-589	64	14	of	of	ADP
bionys-589	64	15	differential	differential	ADJ
bionys-589	64	16	centrifugation	centrifugation	NOUN
bionys-589	64	17	(	(	PUNCT
bionys-589	64	18	3000	3000	NUM
bionys-589	64	19	rpm	rpm	NOUN
bionys-589	64	20	for	for	ADP
bionys-589	64	21	30	30	NUM
bionys-589	64	22	minutes	minute	NOUN
bionys-589	64	23	)	)	PUNCT
bionys-589	64	24	,	,	PUNCT
bionys-589	64	25	refining	refining	NOUN
bionys-589	64	26	of	of	ADP
bionys-589	64	27	the	the	DET
bionys-589	64	28	suspension	suspension	NOUN
bionys-589	64	29	,	,	PUNCT
bionys-589	64	30	and	and	CCONJ
bionys-589	64	31	resuspension	resuspension	NOUN
bionys-589	64	32	of	of	ADP
bionys-589	64	33	the	the	DET
bionys-589	64	34	pellet	pellet	NOUN
bionys-589	64	35	in	in	ADP
bionys-589	64	36	a	a	DET
bionys-589	64	37	final	final	ADJ
bionys-589	64	38	volume	volume	NOUN
bionys-589	64	39	of	of	ADP
bionys-589	64	40	10	10	NUM
bionys-589	64	41	ml	ml	ADV
bionys-589	64	42	distilled	distil	VERB
bionys-589	64	43	water	water	NOUN
bionys-589	64	44	.	.	PUNCT
bionys-589	65	1	finally	finally	ADV
bionys-589	65	2	,	,	PUNCT
bionys-589	65	3	the	the	DET
bionys-589	65	4	nanoparticles	nanoparticle	NOUN
bionys-589	65	5	were	be	AUX
bionys-589	65	6	lyophilized	lyophilize	VERB
bionys-589	65	7	and	and	CCONJ
bionys-589	65	8	stored	store	VERB
bionys-589	65	9	at	at	ADP
bionys-589	65	10	4	4	NUM
bionys-589	65	11	°	°	NOUN
bionys-589	65	12	c	c	NOUN
bionys-589	65	13	(	(	PUNCT
bionys-589	65	14	kim	kim	PROPN
bionys-589	65	15	et	et	PROPN
bionys-589	65	16	al	al	PROPN
bionys-589	65	17	.	.	PROPN
bionys-589	65	18	,	,	PUNCT
bionys-589	65	19	2010	2010	NUM
bionys-589	65	20	)	)	PUNCT
bionys-589	65	21	.	.	PUNCT
bionys-589	66	1	a	a	DET
bionys-589	66	2	total	total	NOUN
bionys-589	66	3	of	of	ADP
bionys-589	66	4	eight	eight	NUM
bionys-589	66	5	formulations	formulation	NOUN
bionys-589	66	6	(	(	PUNCT
bionys-589	66	7	f1	f1	NOUN
bionys-589	66	8	–	–	PUNCT
bionys-589	66	9	f8	f8	PROPN
bionys-589	66	10	)	)	PUNCT
bionys-589	66	11	were	be	AUX
bionys-589	66	12	prepared	prepare	VERB
bionys-589	66	13	with	with	ADP
bionys-589	66	14	varying	vary	VERB
bionys-589	66	15	concentrations	concentration	NOUN
bionys-589	66	16	of	of	ADP
bionys-589	66	17	carrier	carrier	NOUN
bionys-589	66	18	and	and	CCONJ
bionys-589	66	19	drug	drug	NOUN
bionys-589	66	20	ratio	ratio	NOUN
bionys-589	66	21	.	.	PUNCT
bionys-589	67	1	biologica	biologica	PROPN
bionys-589	67	2	nyssana	nyssana	PROPN
bionys-589	68	1	●	●	PUNCT
bionys-589	68	2	16	16	NUM
bionys-589	68	3	(	(	PUNCT
bionys-589	68	4	1	1	NUM
bionys-589	68	5	)	)	PUNCT
bionys-589	68	6	june	june	PROPN
bionys-589	68	7	2025	2025	NUM
bionys-589	68	8	:	:	PUNCT
bionys-589	68	9	267	267	NUM
bionys-589	68	10	-	-	SYM
bionys-589	68	11	276	276	NUM
bionys-589	68	12	alex	alex	PROPN
bionys-589	68	13	et	et	PROPN
bionys-589	68	14	al	al	PROPN
bionys-589	68	15	.	.	PUNCT
bionys-589	69	1	●	●	PUNCT
bionys-589	69	2	formulation	formulation	NOUN
bionys-589	69	3	and	and	CCONJ
bionys-589	69	4	characterization	characterization	NOUN
bionys-589	69	5	of	of	ADP
bionys-589	69	6	nanoparticles	nanoparticle	NOUN
bionys-589	69	7	loaded	load	VERB
bionys-589	69	8	with	with	ADP
bionys-589	69	9	curcumin	curcumin	NOUN
bionys-589	69	10	and	and	CCONJ
bionys-589	69	11	amantadine	amantadine	NOUN
bionys-589	69	12	as	as	ADP
bionys-589	69	13	a	a	DET
bionys-589	69	14	promising	promising	ADJ
bionys-589	69	15	neuroprotective	neuroprotective	ADJ
bionys-589	69	16	agent	agent	NOUN
bionys-589	69	17	269	269	NUM
bionys-589	69	18	biologica	biologica	PROPN
bionys-589	69	19	nyssana	nyssana	PROPN
bionys-589	70	1	●	●	PUNCT
bionys-589	70	2	16	16	NUM
bionys-589	70	3	(	(	PUNCT
bionys-589	70	4	1	1	NUM
bionys-589	70	5	)	)	PUNCT
bionys-589	70	6	june	june	PROPN
bionys-589	70	7	2025	2025	NUM
bionys-589	70	8	:	:	PUNCT
bionys-589	70	9	267	267	NUM
bionys-589	70	10	-	-	SYM
bionys-589	70	11	276	276	NUM
bionys-589	70	12	alex	alex	PROPN
bionys-589	70	13	et	et	PROPN
bionys-589	70	14	al	al	PROPN
bionys-589	70	15	.	.	PUNCT
bionys-589	70	16	●	●	PUNCT
bionys-589	70	17	formulation	formulation	NOUN
bionys-589	70	18	and	and	CCONJ
bionys-589	70	19	characterization	characterization	NOUN
bionys-589	70	20	of	of	ADP
bionys-589	70	21	nanoparticles	nanoparticle	NOUN
bionys-589	70	22	loaded	load	VERB
bionys-589	70	23	with	with	ADP
bionys-589	70	24	curcumin	curcumin	NOUN
bionys-589	70	25	and	and	CCONJ
bionys-589	70	26	amantadine	amantadine	NOUN
bionys-589	70	27	as	as	ADP
bionys-589	70	28	a	a	DET
bionys-589	70	29	promising	promising	ADJ
bionys-589	70	30	neuroprotective	neuroprotective	ADJ
bionys-589	70	31	agent	agent	NOUN
bionys-589	70	32	characterization	characterization	NOUN
bionys-589	70	33	drug	drug	NOUN
bionys-589	70	34	-	-	PUNCT
bionys-589	70	35	excipient	excipient	NOUN
bionys-589	70	36	compatibility	compatibility	NOUN
bionys-589	70	37	studies	study	NOUN
bionys-589	70	38	(	(	PUNCT
bionys-589	70	39	ftir	ftir	NOUN
bionys-589	70	40	)	)	PUNCT
bionys-589	70	41	compatibility	compatibility	NOUN
bionys-589	70	42	between	between	ADP
bionys-589	70	43	the	the	DET
bionys-589	70	44	drug	drug	NOUN
bionys-589	70	45	and	and	CCONJ
bionys-589	70	46	excipients	excipient	NOUN
bionys-589	70	47	used	use	VERB
bionys-589	70	48	in	in	ADP
bionys-589	70	49	the	the	DET
bionys-589	70	50	preparation	preparation	NOUN
bionys-589	70	51	of	of	ADP
bionys-589	70	52	nanoparticles	nanoparticle	NOUN
bionys-589	70	53	was	be	AUX
bionys-589	70	54	confirmed	confirm	VERB
bionys-589	70	55	by	by	ADP
bionys-589	70	56	infrared	infrared	ADJ
bionys-589	70	57	spectroscopy	spectroscopy	NOUN
bionys-589	70	58	.	.	PUNCT
bionys-589	71	1	the	the	DET
bionys-589	71	2	nature	nature	NOUN
bionys-589	71	3	of	of	ADP
bionys-589	71	4	the	the	DET
bionys-589	71	5	interactions	interaction	NOUN
bionys-589	71	6	was	be	AUX
bionys-589	71	7	identified	identify	VERB
bionys-589	71	8	.	.	PUNCT
bionys-589	72	1	the	the	DET
bionys-589	72	2	samples	sample	NOUN
bionys-589	72	3	were	be	AUX
bionys-589	72	4	scanned	scan	VERB
bionys-589	72	5	using	use	VERB
bionys-589	72	6	a	a	DET
bionys-589	72	7	fourier	fourier	NOUN
bionys-589	72	8	transform	transform	NOUN
bionys-589	72	9	infrared	infrared	ADJ
bionys-589	72	10	(	(	PUNCT
bionys-589	72	11	ft	ft	NOUN
bionys-589	72	12	-	-	PUNCT
bionys-589	72	13	ir	ir	NOUN
bionys-589	72	14	)	)	PUNCT
bionys-589	72	15	spectrophotometer	spectrophotometer	NOUN
bionys-589	72	16	in	in	ADP
bionys-589	72	17	the	the	DET
bionys-589	72	18	range	range	NOUN
bionys-589	72	19	of	of	ADP
bionys-589	72	20	4000	4000	NUM
bionys-589	72	21	to	to	PART
bionys-589	72	22	400	400	NUM
bionys-589	72	23	cm⁻¹.	cm⁻¹.	NOUN
bionys-589	72	24	ir	ir	PROPN
bionys-589	72	25	spectra	spectra	NOUN
bionys-589	72	26	of	of	ADP
bionys-589	72	27	all	all	DET
bionys-589	72	28	individual	individual	ADJ
bionys-589	72	29	drugs	drug	NOUN
bionys-589	72	30	and	and	CCONJ
bionys-589	72	31	synthesized	synthesize	VERB
bionys-589	72	32	nanoparticles	nanoparticle	NOUN
bionys-589	72	33	were	be	AUX
bionys-589	72	34	recorded	record	VERB
bionys-589	72	35	.	.	PUNCT
bionys-589	73	1	furthermore	furthermore	ADV
bionys-589	73	2	,	,	PUNCT
bionys-589	73	3	changes	change	NOUN
bionys-589	73	4	in	in	ADP
bionys-589	73	5	appearance	appearance	NOUN
bionys-589	73	6	and	and	CCONJ
bionys-589	73	7	peak	peak	NOUN
bionys-589	73	8	positions	position	NOUN
bionys-589	73	9	were	be	AUX
bionys-589	73	10	studied	study	VERB
bionys-589	73	11	in	in	ADP
bionys-589	73	12	the	the	DET
bionys-589	73	13	spectra	spectra	NOUN
bionys-589	73	14	to	to	PART
bionys-589	73	15	determine	determine	VERB
bionys-589	73	16	the	the	DET
bionys-589	73	17	possibility	possibility	NOUN
bionys-589	73	18	of	of	ADP
bionys-589	73	19	chemical	chemical	NOUN
bionys-589	73	20	and	and	CCONJ
bionys-589	73	21	physical	physical	ADJ
bionys-589	73	22	interactions	interaction	NOUN
bionys-589	73	23	.	.	PUNCT
bionys-589	74	1	particle	particle	NOUN
bionys-589	74	2	shape	shape	NOUN
bionys-589	74	3	and	and	CCONJ
bionys-589	74	4	surface	surface	NOUN
bionys-589	74	5	morphology	morphology	NOUN
bionys-589	74	6	a	a	DET
bionys-589	74	7	scanning	scanning	NOUN
bionys-589	74	8	electron	electron	NOUN
bionys-589	74	9	microscope	microscope	NOUN
bionys-589	74	10	(	(	PUNCT
bionys-589	74	11	sem	sem	PROPN
bionys-589	74	12	;	;	PUNCT
bionys-589	74	13	zeiss	zeiss	PROPN
bionys-589	74	14	evo40	evo40	PROPN
bionys-589	74	15	)	)	PUNCT
bionys-589	74	16	was	be	AUX
bionys-589	74	17	used	use	VERB
bionys-589	74	18	to	to	PART
bionys-589	74	19	examine	examine	VERB
bionys-589	74	20	the	the	DET
bionys-589	74	21	shape	shape	NOUN
bionys-589	74	22	and	and	CCONJ
bionys-589	74	23	morphology	morphology	NOUN
bionys-589	74	24	of	of	ADP
bionys-589	74	25	the	the	DET
bionys-589	74	26	prepared	prepare	VERB
bionys-589	74	27	nanoparticles	nanoparticle	NOUN
bionys-589	74	28	.	.	PUNCT
bionys-589	75	1	samples	sample	NOUN
bionys-589	75	2	were	be	AUX
bionys-589	75	3	spread	spread	VERB
bionys-589	75	4	onto	onto	ADP
bionys-589	75	5	a	a	DET
bionys-589	75	6	slide	slide	NOUN
bionys-589	75	7	using	use	VERB
bionys-589	75	8	double	double	ADJ
bionys-589	75	9	-	-	PUNCT
bionys-589	75	10	sided	sided	ADJ
bionys-589	75	11	sticky	sticky	ADJ
bionys-589	75	12	tape	tape	NOUN
bionys-589	75	13	,	,	PUNCT
bionys-589	75	14	and	and	CCONJ
bionys-589	75	15	the	the	DET
bionys-589	75	16	gold	gold	NOUN
bionys-589	75	17	coating	coating	NOUN
bionys-589	75	18	was	be	AUX
bionys-589	75	19	done	do	VERB
bionys-589	75	20	using	use	VERB
bionys-589	75	21	a	a	DET
bionys-589	75	22	vacuum	vacuum	NOUN
bionys-589	75	23	evaporator	evaporator	NOUN
bionys-589	75	24	in	in	ADP
bionys-589	75	25	an	an	DET
bionys-589	75	26	argon	argon	NOUN
bionys-589	75	27	atmosphere	atmosphere	NOUN
bionys-589	75	28	assisted	assist	VERB
bionys-589	75	29	by	by	ADP
bionys-589	75	30	gold	gold	NOUN
bionys-589	75	31	flakes	flake	NOUN
bionys-589	75	32	.	.	PUNCT
bionys-589	76	1	samples	sample	NOUN
bionys-589	76	2	were	be	AUX
bionys-589	76	3	scanned	scan	VERB
bionys-589	76	4	at	at	ADP
bionys-589	76	5	various	various	ADJ
bionys-589	76	6	magnifications	magnification	NOUN
bionys-589	76	7	,	,	PUNCT
bionys-589	76	8	and	and	CCONJ
bionys-589	76	9	photomicrographs	photomicrograph	NOUN
bionys-589	76	10	were	be	AUX
bionys-589	76	11	captured	capture	VERB
bionys-589	76	12	.	.	PUNCT
bionys-589	77	1	particle	particle	NOUN
bionys-589	77	2	size	size	NOUN
bionys-589	77	3	and	and	CCONJ
bionys-589	77	4	zeta	zeta	NOUN
bionys-589	77	5	potential	potential	NOUN
bionys-589	77	6	a	a	DET
bionys-589	77	7	concentrated	concentrated	ADJ
bionys-589	77	8	solution	solution	NOUN
bionys-589	77	9	of	of	ADP
bionys-589	77	10	1	1	NUM
bionys-589	77	11	ml	ml	NOUN
bionys-589	77	12	albumin	albumin	ADJ
bionys-589	77	13	nanoparticles	nanoparticle	NOUN
bionys-589	77	14	was	be	AUX
bionys-589	77	15	diluted	dilute	VERB
bionys-589	77	16	with	with	ADP
bionys-589	77	17	10	10	NUM
bionys-589	77	18	ml	ml	NOUN
bionys-589	77	19	of	of	ADP
bionys-589	77	20	water	water	NOUN
bionys-589	77	21	.	.	PUNCT
bionys-589	78	1	the	the	DET
bionys-589	78	2	samples	sample	NOUN
bionys-589	78	3	were	be	AUX
bionys-589	78	4	analyzed	analyze	VERB
bionys-589	78	5	using	use	VERB
bionys-589	78	6	dynamic	dynamic	ADJ
bionys-589	78	7	light	light	NOUN
bionys-589	78	8	scattering	scattering	NOUN
bionys-589	78	9	(	(	PUNCT
bionys-589	78	10	dls	dls	PROPN
bionys-589	78	11	)	)	PUNCT
bionys-589	78	12	with	with	ADP
bionys-589	78	13	a	a	DET
bionys-589	78	14	malvern	malvern	ADJ
bionys-589	78	15	zetasizer	zetasizer	NOUN
bionys-589	78	16	.	.	PUNCT
bionys-589	79	1	the	the	DET
bionys-589	79	2	polydispersity	polydispersity	NOUN
bionys-589	79	3	index	index	NOUN
bionys-589	79	4	(	(	PUNCT
bionys-589	79	5	pdi	pdi	PROPN
bionys-589	79	6	)	)	PUNCT
bionys-589	79	7	and	and	CCONJ
bionys-589	79	8	average	average	ADJ
bionys-589	79	9	particle	particle	NOUN
bionys-589	79	10	size	size	NOUN
bionys-589	79	11	were	be	AUX
bionys-589	79	12	determined	determine	VERB
bionys-589	79	13	.	.	PUNCT
bionys-589	80	1	zeta	zeta	PROPN
bionys-589	80	2	potential	potential	NOUN
bionys-589	80	3	was	be	AUX
bionys-589	80	4	measured	measure	VERB
bionys-589	80	5	to	to	PART
bionys-589	80	6	assess	assess	VERB
bionys-589	80	7	formulation	formulation	NOUN
bionys-589	80	8	stability	stability	NOUN
bionys-589	80	9	.	.	PUNCT
bionys-589	81	1	the	the	DET
bionys-589	81	2	surface	surface	NOUN
bionys-589	81	3	charge	charge	NOUN
bionys-589	81	4	potential	potential	NOUN
bionys-589	81	5	of	of	ADP
bionys-589	81	6	the	the	DET
bionys-589	81	7	samples	sample	NOUN
bionys-589	81	8	was	be	AUX
bionys-589	81	9	analyzed	analyze	VERB
bionys-589	81	10	in	in	ADP
bionys-589	81	11	the	the	DET
bionys-589	81	12	zetasizer	zetasizer	PROPN
bionys-589	81	13	chamber	chamber	PROPN
bionys-589	81	14	,	,	PUNCT
bionys-589	81	15	and	and	CCONJ
bionys-589	81	16	peaks	peak	NOUN
bionys-589	81	17	were	be	AUX
bionys-589	81	18	recorded	record	VERB
bionys-589	81	19	to	to	PART
bionys-589	81	20	obtain	obtain	VERB
bionys-589	81	21	zeta	zeta	NOUN
bionys-589	81	22	potential	potential	ADJ
bionys-589	81	23	values	value	NOUN
bionys-589	81	24	.	.	PUNCT
bionys-589	82	1	when	when	SCONJ
bionys-589	82	2	interpreting	interpret	VERB
bionys-589	82	3	the	the	DET
bionys-589	82	4	data	datum	NOUN
bionys-589	82	5	,	,	PUNCT
bionys-589	82	6	a	a	DET
bionys-589	82	7	monodisperse	monodisperse	NOUN
bionys-589	82	8	character	character	NOUN
bionys-589	82	9	is	be	AUX
bionys-589	82	10	considered	consider	VERB
bionys-589	82	11	more	more	ADV
bionys-589	82	12	desirable	desirable	ADJ
bionys-589	82	13	than	than	ADP
bionys-589	82	14	a	a	DET
bionys-589	82	15	polydisperse	polydisperse	NOUN
bionys-589	82	16	one	one	NUM
bionys-589	82	17	.	.	PUNCT
bionys-589	83	1	drug	drug	NOUN
bionys-589	83	2	entrapment	entrapment	ADJ
bionys-589	83	3	efficiency	efficiency	NOUN
bionys-589	83	4	10	10	NUM
bionys-589	83	5	ml	ml	NOUN
bionys-589	83	6	of	of	ADP
bionys-589	83	7	the	the	DET
bionys-589	83	8	nanoparticle	nanoparticle	NOUN
bionys-589	83	9	solution	solution	NOUN
bionys-589	83	10	(	(	PUNCT
bionys-589	83	11	equivalent	equivalent	ADJ
bionys-589	83	12	to	to	ADP
bionys-589	83	13	10	10	NUM
bionys-589	83	14	mg	mg	NOUN
bionys-589	83	15	of	of	ADP
bionys-589	83	16	the	the	DET
bionys-589	83	17	drug	drug	NOUN
bionys-589	83	18	)	)	PUNCT
bionys-589	83	19	was	be	AUX
bionys-589	83	20	transferred	transfer	VERB
bionys-589	83	21	into	into	ADP
bionys-589	83	22	a	a	DET
bionys-589	83	23	centrifuge	centrifuge	NOUN
bionys-589	83	24	tube	tube	NOUN
bionys-589	83	25	.	.	PUNCT
bionys-589	84	1	the	the	DET
bionys-589	84	2	mixture	mixture	NOUN
bionys-589	84	3	was	be	AUX
bionys-589	84	4	centrifuged	centrifuge	VERB
bionys-589	84	5	using	use	VERB
bionys-589	84	6	a	a	DET
bionys-589	84	7	refrigerated	refrigerate	VERB
bionys-589	84	8	centrifuge	centrifuge	NOUN
bionys-589	84	9	(	(	PUNCT
bionys-589	84	10	remi	remi	PROPN
bionys-589	84	11	motors	motors	PROPN
bionys-589	84	12	,	,	PUNCT
bionys-589	84	13	c-24	c-24	PROPN
bionys-589	84	14	plus	plus	CCONJ
bionys-589	84	15	)	)	PUNCT
bionys-589	84	16	at	at	ADP
bionys-589	84	17	1000	1000	NUM
bionys-589	84	18	rpm	rpm	NOUN
bionys-589	84	19	for	for	ADP
bionys-589	84	20	15	15	NUM
bionys-589	84	21	minutes	minute	NOUN
bionys-589	84	22	at	at	ADP
bionys-589	84	23	25	25	NUM
bionys-589	84	24	°	°	NOUN
bionys-589	84	25	c	c	NOUN
bionys-589	84	26	.	.	PUNCT
bionys-589	85	1	the	the	DET
bionys-589	85	2	supernatant	supernatant	NOUN
bionys-589	85	3	was	be	AUX
bionys-589	85	4	collected	collect	VERB
bionys-589	85	5	,	,	PUNCT
bionys-589	85	6	and	and	CCONJ
bionys-589	85	7	drug	drug	NOUN
bionys-589	85	8	content	content	NOUN
bionys-589	85	9	was	be	AUX
bionys-589	85	10	quantified	quantify	VERB
bionys-589	85	11	using	use	VERB
bionys-589	85	12	a	a	DET
bionys-589	85	13	calibration	calibration	NOUN
bionys-589	85	14	curve	curve	NOUN
bionys-589	85	15	established	establish	VERB
bionys-589	85	16	by	by	ADP
bionys-589	85	17	uv	uv	NOUN
bionys-589	85	18	-	-	PUNCT
bionys-589	85	19	visible	visible	ADJ
bionys-589	85	20	spectrophotometry	spectrophotometry	NOUN
bionys-589	85	21	.	.	PUNCT
bionys-589	86	1	entrapment	entrapment	ADJ
bionys-589	86	2	efficiency	efficiency	NOUN
bionys-589	86	3	was	be	AUX
bionys-589	86	4	calculated	calculate	VERB
bionys-589	86	5	using	use	VERB
bionys-589	86	6	the	the	DET
bionys-589	86	7	formula	formula	NOUN
bionys-589	86	8	:	:	PUNCT
bionys-589	86	9	encapsulation	encapsulation	NOUN
bionys-589	86	10	efficiency	efficiency	NOUN
bionys-589	86	11	(	(	PUNCT
bionys-589	86	12	%	%	INTJ
bionys-589	86	13	ee)=[(total	ee)=[(total	ADJ
bionys-589	86	14	drug	drug	NOUN
bionys-589	86	15	added	add	VERB
bionys-589	86	16	–	–	PUNCT
bionys-589	86	17	free	free	ADJ
bionys-589	86	18	drug	drug	NOUN
bionys-589	86	19	in	in	ADP
bionys-589	86	20	supernatant)/total	supernatant)/total	ADJ
bionys-589	86	21	drug	drug	NOUN
bionys-589	86	22	added]×100	added]×100	NOUN
bionys-589	86	23	in	in	ADP
bionys-589	86	24	vitro	vitro	X
bionys-589	86	25	drug	drug	NOUN
bionys-589	86	26	release	release	NOUN
bionys-589	86	27	study	study	VERB
bionys-589	86	28	the	the	DET
bionys-589	86	29	drug	drug	NOUN
bionys-589	86	30	's	's	PART
bionys-589	86	31	release	release	NOUN
bionys-589	86	32	behavior	behavior	NOUN
bionys-589	86	33	from	from	ADP
bionys-589	86	34	albumin	albumin	ADJ
bionys-589	86	35	nanoparticles	nanoparticle	NOUN
bionys-589	86	36	was	be	AUX
bionys-589	86	37	evaluated	evaluate	VERB
bionys-589	86	38	using	use	VERB
bionys-589	86	39	the	the	DET
bionys-589	86	40	dialysis	dialysis	NOUN
bionys-589	86	41	bag	bag	NOUN
bionys-589	86	42	method	method	NOUN
bionys-589	86	43	.	.	PUNCT
bionys-589	87	1	a	a	DET
bionys-589	87	2	predetermined	predetermine	VERB
bionys-589	87	3	volume	volume	NOUN
bionys-589	87	4	of	of	ADP
bionys-589	87	5	aqueous	aqueous	ADJ
bionys-589	87	6	nanoparticle	nanoparticle	NOUN
bionys-589	87	7	suspension	suspension	NOUN
bionys-589	87	8	was	be	AUX
bionys-589	87	9	sealed	seal	VERB
bionys-589	87	10	in	in	ADP
bionys-589	87	11	a	a	DET
bionys-589	87	12	dialysis	dialysis	NOUN
bionys-589	87	13	bag	bag	NOUN
bionys-589	87	14	and	and	CCONJ
bionys-589	87	15	immersed	immerse	VERB
bionys-589	87	16	in	in	ADP
bionys-589	87	17	phosphate	phosphate	NOUN
bionys-589	87	18	-	-	PUNCT
bionys-589	87	19	buffered	buffer	VERB
bionys-589	87	20	saline	saline	NOUN
bionys-589	87	21	(	(	PUNCT
bionys-589	87	22	pbs	pbs	PROPN
bionys-589	87	23	,	,	PUNCT
bionys-589	87	24	ph	ph	NOUN
bionys-589	87	25	7.4	7.4	NUM
bionys-589	87	26	)	)	PUNCT
bionys-589	87	27	at	at	ADP
bionys-589	87	28	37	37	NUM
bionys-589	87	29	°	°	NOUN
bionys-589	87	30	c	c	NOUN
bionys-589	87	31	with	with	ADP
bionys-589	87	32	stirring	stir	VERB
bionys-589	87	33	at	at	ADP
bionys-589	87	34	100	100	NUM
bionys-589	87	35	rpm	rpm	NOUN
bionys-589	87	36	.	.	PUNCT
bionys-589	88	1	samples	sample	NOUN
bionys-589	88	2	were	be	AUX
bionys-589	88	3	withdrawn	withdraw	VERB
bionys-589	88	4	from	from	ADP
bionys-589	88	5	the	the	DET
bionys-589	88	6	release	release	NOUN
bionys-589	88	7	medium	medium	NOUN
bionys-589	88	8	at	at	ADP
bionys-589	88	9	specific	specific	ADJ
bionys-589	88	10	intervals	interval	NOUN
bionys-589	88	11	and	and	CCONJ
bionys-589	88	12	replaced	replace	VERB
bionys-589	88	13	with	with	ADP
bionys-589	88	14	fresh	fresh	ADJ
bionys-589	88	15	pbs	pbs	PROPN
bionys-589	88	16	.	.	PUNCT
bionys-589	89	1	samples	sample	NOUN
bionys-589	89	2	were	be	AUX
bionys-589	89	3	centrifuged	centrifuge	VERB
bionys-589	89	4	,	,	PUNCT
bionys-589	89	5	and	and	CCONJ
bionys-589	89	6	the	the	DET
bionys-589	89	7	drug	drug	NOUN
bionys-589	89	8	content	content	NOUN
bionys-589	89	9	in	in	ADP
bionys-589	89	10	the	the	DET
bionys-589	89	11	supernatant	supernatant	NOUN
bionys-589	89	12	was	be	AUX
bionys-589	89	13	determined	determine	VERB
bionys-589	89	14	using	use	VERB
bionys-589	89	15	hplc	hplc	NOUN
bionys-589	89	16	or	or	CCONJ
bionys-589	89	17	fluorescence	fluorescence	ADJ
bionys-589	89	18	/	/	SYM
bionys-589	89	19	uvvisible	uvvisible	ADJ
bionys-589	89	20	spectrophotometry	spectrophotometry	NOUN
bionys-589	89	21	.	.	PUNCT
bionys-589	90	1	a	a	DET
bionys-589	90	2	graph	graph	NOUN
bionys-589	90	3	of	of	ADP
bionys-589	90	4	cumulative	cumulative	ADJ
bionys-589	90	5	drug	drug	NOUN
bionys-589	90	6	release	release	NOUN
bionys-589	90	7	versus	versus	ADP
bionys-589	90	8	time	time	NOUN
bionys-589	90	9	was	be	AUX
bionys-589	90	10	plotted	plot	VERB
bionys-589	90	11	.	.	PUNCT
bionys-589	91	1	release	release	VERB
bionys-589	91	2	kinetics	kinetic	NOUN
bionys-589	91	3	study	study	NOUN
bionys-589	91	4	in	in	ADP
bionys-589	91	5	hydrophilic	hydrophilic	ADJ
bionys-589	91	6	matrices	matrix	NOUN
bionys-589	91	7	,	,	PUNCT
bionys-589	91	8	polymers	polymer	NOUN
bionys-589	91	9	swell	swell	VERB
bionys-589	91	10	and	and	CCONJ
bionys-589	91	11	erode	erode	VERB
bionys-589	91	12	simultaneously	simultaneously	ADV
bionys-589	91	13	,	,	PUNCT
bionys-589	91	14	contributing	contribute	VERB
bionys-589	91	15	to	to	ADP
bionys-589	91	16	drug	drug	NOUN
bionys-589	91	17	release	release	NOUN
bionys-589	91	18	.	.	PUNCT
bionys-589	92	1	the	the	DET
bionys-589	92	2	resulting	result	VERB
bionys-589	92	3	release	release	NOUN
bionys-589	92	4	profile	profile	NOUN
bionys-589	92	5	often	often	ADV
bionys-589	92	6	reflects	reflect	VERB
bionys-589	92	7	zero	zero	NUM
bionys-589	92	8	-	-	PUNCT
bionys-589	92	9	order	order	NOUN
bionys-589	92	10	kinetics	kinetic	NOUN
bionys-589	92	11	.	.	PUNCT
bionys-589	93	1	this	this	DET
bionys-589	93	2	study	study	NOUN
bionys-589	93	3	prepared	prepare	VERB
bionys-589	93	4	a	a	DET
bionys-589	93	5	nanoformulation	nanoformulation	NOUN
bionys-589	93	6	loaded	load	VERB
bionys-589	93	7	with	with	ADP
bionys-589	93	8	curcumin	curcumin	NOUN
bionys-589	93	9	and	and	CCONJ
bionys-589	93	10	amantadine	amantadine	NOUN
bionys-589	93	11	for	for	ADP
bionys-589	93	12	sustained	sustained	ADJ
bionys-589	93	13	release	release	NOUN
bionys-589	93	14	.	.	PUNCT
bionys-589	94	1	the	the	DET
bionys-589	94	2	drug	drug	NOUN
bionys-589	94	3	release	release	NOUN
bionys-589	94	4	data	datum	NOUN
bionys-589	94	5	were	be	AUX
bionys-589	94	6	fitted	fit	VERB
bionys-589	94	7	to	to	ADP
bionys-589	94	8	various	various	ADJ
bionys-589	94	9	kinetic	kinetic	ADJ
bionys-589	94	10	models	model	NOUN
bionys-589	94	11	:	:	PUNCT
bionys-589	94	12	zero	zero	NUM
bionys-589	94	13	-	-	PUNCT
bionys-589	94	14	order	order	NOUN
bionys-589	94	15	(	(	PUNCT
bionys-589	94	16	cumulative	cumulative	ADJ
bionys-589	94	17	%	%	NOUN
bionys-589	94	18	drug	drug	NOUN
bionys-589	94	19	released	release	VERB
bionys-589	94	20	vs.	vs.	ADP
bionys-589	94	21	time	time	NOUN
bionys-589	94	22	)	)	PUNCT
bionys-589	94	23	,	,	PUNCT
bionys-589	94	24	first	first	ADJ
bionys-589	94	25	-	-	PUNCT
bionys-589	94	26	order	order	NOUN
bionys-589	94	27	(	(	PUNCT
bionys-589	94	28	log	log	NOUN
bionys-589	94	29	%	%	NOUN
bionys-589	94	30	drug	drug	NOUN
bionys-589	94	31	remaining	remain	VERB
bionys-589	94	32	vs.	vs.	ADP
bionys-589	94	33	time	time	NOUN
bionys-589	94	34	)	)	PUNCT
bionys-589	94	35	,	,	PUNCT
bionys-589	94	36	higuchi	higuchi	PROPN
bionys-589	94	37	's	's	PART
bionys-589	94	38	model	model	NOUN
bionys-589	94	39	(	(	PUNCT
bionys-589	94	40	cumulative	cumulative	ADJ
bionys-589	94	41	%	%	NOUN
bionys-589	94	42	drug	drug	NOUN
bionys-589	94	43	released	release	VERB
bionys-589	94	44	vs.	vs.	ADP
bionys-589	94	45	square	square	ADJ
bionys-589	94	46	root	root	NOUN
bionys-589	94	47	of	of	ADP
bionys-589	94	48	time	time	NOUN
bionys-589	94	49	)	)	PUNCT
bionys-589	94	50	,	,	PUNCT
bionys-589	94	51	and	and	CCONJ
bionys-589	94	52	korsmeyer	korsmeyer	NOUN
bionys-589	94	53	–	–	PUNCT
bionys-589	94	54	peppas	peppas	NOUN
bionys-589	94	55	model	model	NOUN
bionys-589	94	56	(	(	PUNCT
bionys-589	94	57	log	log	NOUN
bionys-589	94	58	%	%	NOUN
bionys-589	94	59	drug	drug	NOUN
bionys-589	94	60	released	release	VERB
bionys-589	94	61	vs.	vs.	ADP
bionys-589	94	62	log	log	NOUN
bionys-589	94	63	time	time	NOUN
bionys-589	94	64	)	)	PUNCT
bionys-589	94	65	.	.	PUNCT
bionys-589	95	1	the	the	DET
bionys-589	95	2	physicochemical	physicochemical	ADJ
bionys-589	95	3	properties	property	NOUN
bionys-589	95	4	,	,	PUNCT
bionys-589	95	5	effectiveness	effectiveness	NOUN
bionys-589	95	6	,	,	PUNCT
bionys-589	95	7	and	and	CCONJ
bionys-589	95	8	quality	quality	NOUN
bionys-589	95	9	of	of	ADP
bionys-589	95	10	the	the	DET
bionys-589	95	11	nanoparticles	nanoparticle	NOUN
bionys-589	95	12	were	be	AUX
bionys-589	95	13	assessed	assess	VERB
bionys-589	95	14	using	use	VERB
bionys-589	95	15	these	these	DET
bionys-589	95	16	models	model	NOUN
bionys-589	95	17	.	.	PUNCT
bionys-589	96	1	in	in	ADP
bionys-589	96	2	vitro	vitro	X
bionys-589	96	3	neuroprotective	neuroprotective	ADJ
bionys-589	96	4	effect	effect	NOUN
bionys-589	96	5	determination	determination	NOUN
bionys-589	96	6	by	by	ADP
bionys-589	96	7	mtt	mtt	PROPN
bionys-589	96	8	assay	assay	PROPN
bionys-589	96	9	sh	sh	PROPN
bionys-589	96	10	-	-	PUNCT
bionys-589	96	11	sy5y	sy5y	PROPN
bionys-589	96	12	(	(	PUNCT
bionys-589	96	13	neuroblastoma	neuroblastoma	NOUN
bionys-589	96	14	)	)	PUNCT
bionys-589	96	15	cell	cell	NOUN
bionys-589	96	16	line	line	NOUN
bionys-589	96	17	was	be	AUX
bionys-589	96	18	procured	procure	VERB
bionys-589	96	19	from	from	ADP
bionys-589	96	20	the	the	DET
bionys-589	96	21	national	national	ADJ
bionys-589	96	22	centre	centre	NOUN
bionys-589	96	23	for	for	ADP
bionys-589	96	24	cell	cell	NOUN
bionys-589	96	25	sciences	science	NOUN
bionys-589	96	26	(	(	PUNCT
bionys-589	96	27	nccs	nccs	PROPN
bionys-589	96	28	)	)	PUNCT
bionys-589	96	29	,	,	PUNCT
bionys-589	96	30	pune	pune	NOUN
bionys-589	96	31	,	,	PUNCT
bionys-589	96	32	india	india	PROPN
bionys-589	96	33	,	,	PUNCT
bionys-589	96	34	and	and	CCONJ
bionys-589	96	35	maintained	maintain	VERB
bionys-589	96	36	in	in	ADP
bionys-589	96	37	dulbecco	dulbecco	NOUN
bionys-589	96	38	’s	’s	PART
bionys-589	96	39	modified	modified	PROPN
bionys-589	96	40	eagle	eagle	PROPN
bionys-589	96	41	’s	’s	PART
bionys-589	96	42	medium	medium	NOUN
bionys-589	96	43	(	(	PUNCT
bionys-589	96	44	dmem	dmem	ADJ
bionys-589	96	45	;	;	PUNCT
bionys-589	96	46	sigma	sigma	PROPN
bionys-589	96	47	aldrich	aldrich	PROPN
bionys-589	96	48	,	,	PUNCT
bionys-589	96	49	usa	usa	PROPN
bionys-589	96	50	)	)	PUNCT
bionys-589	96	51	.	.	PUNCT
bionys-589	97	1	cells	cell	NOUN
bionys-589	97	2	were	be	AUX
bionys-589	97	3	cultured	cultured	ADJ
bionys-589	97	4	in	in	ADP
bionys-589	97	5	25	25	NUM
bionys-589	97	6	cm²	cm²	ADP
bionys-589	97	7	tissue	tissue	NOUN
bionys-589	97	8	culture	culture	NOUN
bionys-589	97	9	flasks	flask	NOUN
bionys-589	97	10	with	with	ADP
bionys-589	97	11	dmem	dmem	VERB
bionys-589	97	12	supplemented	supplement	VERB
bionys-589	97	13	with	with	ADP
bionys-589	97	14	10	10	NUM
bionys-589	97	15	%	%	NOUN
bionys-589	97	16	fetal	fetal	ADJ
bionys-589	97	17	bovine	bovine	NOUN
bionys-589	97	18	serum	serum	NOUN
bionys-589	97	19	(	(	PUNCT
bionys-589	97	20	fbs	fbs	PROPN
bionys-589	97	21	)	)	PUNCT
bionys-589	97	22	,	,	PUNCT
bionys-589	97	23	l	l	NOUN
bionys-589	97	24	-	-	NOUN
bionys-589	97	25	glutamine	glutamine	NOUN
bionys-589	97	26	,	,	PUNCT
bionys-589	97	27	sodium	sodium	NOUN
bionys-589	97	28	bicarbonate	bicarbonate	NOUN
bionys-589	97	29	(	(	PUNCT
bionys-589	97	30	merck	merck	PROPN
bionys-589	97	31	,	,	PUNCT
bionys-589	97	32	germany	germany	PROPN
bionys-589	97	33	)	)	PUNCT
bionys-589	97	34	,	,	PUNCT
bionys-589	97	35	and	and	CCONJ
bionys-589	97	36	antibiotics	antibiotic	NOUN
bionys-589	97	37	:	:	PUNCT
bionys-589	97	38	penicillin	penicillin	NOUN
bionys-589	97	39	(	(	PUNCT
bionys-589	97	40	100	100	NUM
bionys-589	97	41	u	u	NOUN
bionys-589	97	42	/	/	SYM
bionys-589	97	43	ml	ml	NOUN
bionys-589	97	44	)	)	PUNCT
bionys-589	97	45	,	,	PUNCT
bionys-589	97	46	streptomycin	streptomycin	PROPN
bionys-589	97	47	(	(	PUNCT
bionys-589	97	48	100	100	NUM
bionys-589	97	49	µg	µg	NOUN
bionys-589	97	50	/	/	SYM
bionys-589	97	51	ml	ml	NOUN
bionys-589	97	52	)	)	PUNCT
bionys-589	97	53	,	,	PUNCT
bionys-589	97	54	and	and	CCONJ
bionys-589	97	55	amphotericin	amphotericin	ADP
bionys-589	97	56	b	b	X
bionys-589	97	57	(	(	PUNCT
bionys-589	97	58	2.5	2.5	NUM
bionys-589	97	59	µg	µg	NOUN
bionys-589	97	60	/	/	SYM
bionys-589	97	61	ml	ml	NOUN
bionys-589	97	62	)	)	PUNCT
bionys-589	97	63	.	.	PUNCT
bionys-589	98	1	cultures	culture	NOUN
bionys-589	98	2	were	be	AUX
bionys-589	98	3	maintained	maintain	VERB
bionys-589	98	4	at	at	ADP
bionys-589	98	5	37	37	NUM
bionys-589	98	6	°	°	NOUN
bionys-589	98	7	c	c	NOUN
bionys-589	98	8	in	in	ADP
bionys-589	98	9	a	a	DET
bionys-589	98	10	humidified	humidified	ADJ
bionys-589	98	11	5	5	NUM
bionys-589	98	12	%	%	NOUN
bionys-589	98	13	co₂	co₂	NOUN
bionys-589	98	14	incubator	incubator	NOUN
bionys-589	98	15	(	(	PUNCT
bionys-589	98	16	nbs	nbs	PROPN
bionys-589	98	17	eppendorf	eppendorf	PROPN
bionys-589	98	18	,	,	PUNCT
bionys-589	98	19	germany	germany	PROPN
bionys-589	98	20	)	)	PUNCT
bionys-589	98	21	.	.	PUNCT
bionys-589	99	1	cell	cell	NOUN
bionys-589	99	2	viability	viability	NOUN
bionys-589	99	3	was	be	AUX
bionys-589	99	4	assessed	assess	VERB
bionys-589	99	5	by	by	ADP
bionys-589	99	6	inverted	inverted	ADJ
bionys-589	99	7	phase	phase	NOUN
bionys-589	99	8	-	-	PUNCT
bionys-589	99	9	contrast	contrast	NOUN
bionys-589	99	10	microscopy	microscopy	NOUN
bionys-589	99	11	and	and	CCONJ
bionys-589	99	12	further	far	ADV
bionys-589	99	13	confirmed	confirm	VERB
bionys-589	99	14	via	via	ADP
bionys-589	99	15	mtt	mtt	NOUN
bionys-589	99	16	assay	assay	VERB
bionys-589	99	17	.	.	PUNCT
bionys-589	100	1	cytotoxicity	cytotoxicity	NOUN
bionys-589	100	2	evaluation	evaluation	NOUN
bionys-589	100	3	once	once	SCONJ
bionys-589	100	4	cells	cell	NOUN
bionys-589	100	5	reached	reach	VERB
bionys-589	100	6	sufficient	sufficient	ADJ
bionys-589	100	7	growth	growth	NOUN
bionys-589	100	8	,	,	PUNCT
bionys-589	100	9	rotenone	rotenone	NOUN
bionys-589	100	10	(	(	PUNCT
bionys-589	100	11	10	10	NUM
bionys-589	100	12	µm	µm	NOUN
bionys-589	100	13	)	)	PUNCT
bionys-589	100	14	was	be	AUX
bionys-589	100	15	added	add	VERB
bionys-589	100	16	to	to	PART
bionys-589	100	17	induce	induce	VERB
bionys-589	100	18	cytotoxicity	cytotoxicity	NOUN
bionys-589	100	19	and	and	CCONJ
bionys-589	100	20	incubated	incubate	VERB
bionys-589	100	21	for	for	ADP
bionys-589	100	22	1	1	NUM
bionys-589	100	23	hour	hour	NOUN
bionys-589	100	24	.	.	PUNCT
bionys-589	101	1	after	after	ADP
bionys-589	101	2	incubation	incubation	NOUN
bionys-589	101	3	,	,	PUNCT
bionys-589	101	4	the	the	DET
bionys-589	101	5	medium	medium	NOUN
bionys-589	101	6	was	be	AUX
bionys-589	101	7	removed	remove	VERB
bionys-589	101	8	,	,	PUNCT
bionys-589	101	9	and	and	CCONJ
bionys-589	101	10	freshly	freshly	ADV
bionys-589	101	11	prepared	prepare	VERB
bionys-589	101	12	compounds	compound	NOUN
bionys-589	101	13	were	be	AUX
bionys-589	101	14	added	add	VERB
bionys-589	101	15	in	in	ADP
bionys-589	101	16	concentrations	concentration	NOUN
bionys-589	101	17	of	of	ADP
bionys-589	101	18	25	25	NUM
bionys-589	101	19	,	,	PUNCT
bionys-589	101	20	12.5	12.5	NUM
bionys-589	101	21	,	,	PUNCT
bionys-589	101	22	6.25	6.25	NUM
bionys-589	101	23	,	,	PUNCT
bionys-589	101	24	3.1	3.1	NUM
bionys-589	101	25	,	,	PUNCT
bionys-589	101	26	and	and	CCONJ
bionys-589	101	27	1.5	1.5	NUM
bionys-589	101	28	µg	µg	NOUN
bionys-589	101	29	/	/	SYM
bionys-589	101	30	ml	ml	NOUN
bionys-589	101	31	.	.	PUNCT
bionys-589	102	1	each	each	DET
bionys-589	102	2	concentration	concentration	NOUN
bionys-589	102	3	was	be	AUX
bionys-589	102	4	added	add	VERB
bionys-589	102	5	in	in	ADP
bionys-589	102	6	triplicate	triplicate	NOUN
bionys-589	102	7	to	to	ADP
bionys-589	102	8	the	the	DET
bionys-589	102	9	respective	respective	ADJ
bionys-589	102	10	wells	well	NOUN
bionys-589	102	11	.	.	PUNCT
bionys-589	103	1	control	control	NOUN
bionys-589	103	2	and	and	CCONJ
bionys-589	103	3	rotenone	rotenone	NOUN
bionys-589	103	4	-	-	PUNCT
bionys-589	103	5	only	only	ADJ
bionys-589	103	6	wells	well	NOUN
bionys-589	103	7	were	be	AUX
bionys-589	103	8	maintained	maintain	VERB
bionys-589	103	9	for	for	ADP
bionys-589	103	10	comparison	comparison	NOUN
bionys-589	103	11	.	.	PUNCT
bionys-589	104	1	microscopic	microscopic	ADJ
bionys-589	104	2	observation	observation	NOUN
bionys-589	104	3	after	after	ADP
bionys-589	104	4	24	24	NUM
bionys-589	104	5	hours	hour	NOUN
bionys-589	104	6	of	of	ADP
bionys-589	104	7	treatment	treatment	NOUN
bionys-589	104	8	,	,	PUNCT
bionys-589	104	9	plates	plate	NOUN
bionys-589	104	10	were	be	AUX
bionys-589	104	11	observed	observe	VERB
bionys-589	104	12	270	270	NUM
bionys-589	104	13	under	under	ADP
bionys-589	104	14	an	an	DET
bionys-589	104	15	inverted	inverted	ADJ
bionys-589	104	16	phase	phase	NOUN
bionys-589	104	17	contrast	contrast	NOUN
bionys-589	104	18	microscope	microscope	NOUN
bionys-589	104	19	(	(	PUNCT
bionys-589	104	20	olympus	olympus	X
bionys-589	104	21	ckx41	ckx41	NOUN
bionys-589	104	22	with	with	ADP
bionys-589	104	23	optika	optika	ADJ
bionys-589	104	24	pro5	pro5	PROPN
bionys-589	104	25	ccd	ccd	PROPN
bionys-589	104	26	camera	camera	NOUN
bionys-589	104	27	)	)	PUNCT
bionys-589	104	28	.	.	PUNCT
bionys-589	105	1	morphological	morphological	ADJ
bionys-589	105	2	changes	change	NOUN
bionys-589	105	3	such	such	ADJ
bionys-589	105	4	as	as	ADP
bionys-589	105	5	cell	cell	NOUN
bionys-589	105	6	rounding	rounding	NOUN
bionys-589	105	7	,	,	PUNCT
bionys-589	105	8	shrinkage	shrinkage	NOUN
bionys-589	105	9	,	,	PUNCT
bionys-589	105	10	granulation	granulation	NOUN
bionys-589	105	11	,	,	PUNCT
bionys-589	105	12	and	and	CCONJ
bionys-589	105	13	vacuolization	vacuolization	NOUN
bionys-589	105	14	were	be	AUX
bionys-589	105	15	noted	note	VERB
bionys-589	105	16	as	as	ADP
bionys-589	105	17	indicators	indicator	NOUN
bionys-589	105	18	of	of	ADP
bionys-589	105	19	cytotoxicity	cytotoxicity	NOUN
bionys-589	105	20	.	.	PUNCT
bionys-589	106	1	mtt	mtt	PROPN
bionys-589	106	2	assay	assay	VERB
bionys-589	106	3	fifteen	fifteen	NUM
bionys-589	106	4	mg	mg	NOUN
bionys-589	106	5	of	of	ADP
bionys-589	106	6	mtt	mtt	PROPN
bionys-589	106	7	(	(	PUNCT
bionys-589	106	8	sigma	sigma	PROPN
bionys-589	106	9	,	,	PUNCT
bionys-589	106	10	m-5655	m-5655	PROPN
bionys-589	106	11	)	)	PUNCT
bionys-589	106	12	was	be	AUX
bionys-589	106	13	reconstituted	reconstitute	VERB
bionys-589	106	14	in	in	ADP
bionys-589	106	15	3	3	NUM
bionys-589	106	16	ml	ml	NOUN
bionys-589	106	17	pbs	pbs	PROPN
bionys-589	106	18	and	and	CCONJ
bionys-589	106	19	sterilized	sterilize	VERB
bionys-589	106	20	by	by	ADP
bionys-589	106	21	filtration	filtration	NOUN
bionys-589	106	22	.	.	PUNCT
bionys-589	107	1	after	after	ADP
bionys-589	107	2	24	24	NUM
bionys-589	107	3	hours	hour	NOUN
bionys-589	107	4	of	of	ADP
bionys-589	107	5	incubation	incubation	NOUN
bionys-589	107	6	,	,	PUNCT
bionys-589	107	7	30	30	NUM
bionys-589	107	8	µl	µl	NOUN
bionys-589	107	9	of	of	ADP
bionys-589	107	10	mtt	mtt	NOUN
bionys-589	107	11	solution	solution	NOUN
bionys-589	107	12	was	be	AUX
bionys-589	107	13	added	add	VERB
bionys-589	107	14	to	to	ADP
bionys-589	107	15	each	each	DET
bionys-589	107	16	well	well	ADV
bionys-589	107	17	and	and	CCONJ
bionys-589	107	18	incubated	incubate	VERB
bionys-589	107	19	for	for	ADP
bionys-589	107	20	4	4	NUM
bionys-589	107	21	hours	hour	NOUN
bionys-589	107	22	at	at	ADP
bionys-589	107	23	37	37	NUM
bionys-589	107	24	°	°	SYM
bionys-589	107	25	c	c	NOUN
bionys-589	107	26	in	in	ADP
bionys-589	107	27	a	a	DET
bionys-589	107	28	humidified	humidified	ADJ
bionys-589	107	29	5	5	NUM
bionys-589	107	30	%	%	NOUN
bionys-589	107	31	co₂	co₂	NOUN
bionys-589	107	32	incubator	incubator	NOUN
bionys-589	107	33	.	.	PUNCT
bionys-589	108	1	after	after	ADP
bionys-589	108	2	incubation	incubation	NOUN
bionys-589	108	3	,	,	PUNCT
bionys-589	108	4	the	the	DET
bionys-589	108	5	supernatant	supernatant	NOUN
bionys-589	108	6	was	be	AUX
bionys-589	108	7	removed	remove	VERB
bionys-589	108	8	,	,	PUNCT
bionys-589	108	9	and	and	CCONJ
bionys-589	108	10	100	100	NUM
bionys-589	108	11	µl	µl	NOUN
bionys-589	108	12	of	of	ADP
bionys-589	108	13	dmso	dmso	NOUN
bionys-589	108	14	(	(	PUNCT
bionys-589	108	15	sigma	sigma	PROPN
bionys-589	108	16	aldrich	aldrich	PROPN
bionys-589	108	17	,	,	PUNCT
bionys-589	108	18	usa	usa	PROPN
bionys-589	108	19	)	)	PUNCT
bionys-589	108	20	was	be	AUX
bionys-589	108	21	added	add	VERB
bionys-589	108	22	to	to	PART
bionys-589	108	23	dissolve	dissolve	VERB
bionys-589	108	24	the	the	DET
bionys-589	108	25	formazan	formazan	ADJ
bionys-589	108	26	crystals	crystal	NOUN
bionys-589	108	27	.	.	PUNCT
bionys-589	109	1	absorbance	absorbance	NOUN
bionys-589	109	2	was	be	AUX
bionys-589	109	3	read	read	VERB
bionys-589	109	4	using	use	VERB
bionys-589	109	5	a	a	DET
bionys-589	109	6	microplate	microplate	NOUN
bionys-589	109	7	reader	reader	NOUN
bionys-589	109	8	at	at	ADP
bionys-589	109	9	540	540	NUM
bionys-589	109	10	nm	nm	NOUN
bionys-589	109	11	(	(	PUNCT
bionys-589	109	12	talarico	talarico	NOUN
bionys-589	109	13	et	et	NOUN
bionys-589	109	14	al	al	PROPN
bionys-589	109	15	.	.	PROPN
bionys-589	109	16	,	,	PUNCT
bionys-589	109	17	2004	2004	NUM
bionys-589	109	18	)	)	PUNCT
bionys-589	109	19	.	.	PUNCT
bionys-589	110	1	the	the	DET
bionys-589	110	2	percentage	percentage	NOUN
bionys-589	110	3	of	of	ADP
bionys-589	110	4	growth	growth	NOUN
bionys-589	110	5	inhibition	inhibition	NOUN
bionys-589	110	6	was	be	AUX
bionys-589	110	7	calculated	calculate	VERB
bionys-589	110	8	using	use	VERB
bionys-589	110	9	the	the	DET
bionys-589	110	10	formula	formula	NOUN
bionys-589	110	11	:	:	PUNCT
bionys-589	110	12	%	%	NOUN
bionys-589	110	13	of	of	ADP
bionys-589	110	14	viability	viability	NOUN
bionys-589	110	15	=	=	PUNCT
bionys-589	110	16	(	(	PUNCT
bionys-589	110	17	mean	mean	INTJ
bionys-589	110	18	od	od	NUM
bionys-589	110	19	samples	sample	NOUN
bionys-589	110	20	x	x	SYM
bionys-589	110	21	100)/	100)/	NOUN
bionys-589	110	22	mean	mean	VERB
bionys-589	110	23	od	od	INTJ
bionys-589	110	24	of	of	ADP
bionys-589	110	25	control	control	PROPN
bionys-589	110	26	group	group	NOUN
bionys-589	110	27	results	result	NOUN
bionys-589	110	28	and	and	CCONJ
bionys-589	110	29	discussion	discussion	NOUN
bionys-589	110	30	particle	particle	NOUN
bionys-589	110	31	size	size	NOUN
bionys-589	110	32	,	,	PUNCT
bionys-589	110	33	pdi	pdi	NOUN
bionys-589	110	34	,	,	PUNCT
bionys-589	110	35	and	and	CCONJ
bionys-589	110	36	zeta	zeta	PROPN
bionys-589	110	37	potential	potential	VERB
bionys-589	110	38	the	the	DET
bionys-589	110	39	particle	particle	NOUN
bionys-589	110	40	size	size	NOUN
bionys-589	110	41	and	and	CCONJ
bionys-589	110	42	pdi	pdi	NOUN
bionys-589	110	43	of	of	ADP
bionys-589	110	44	the	the	DET
bionys-589	110	45	nanoparticles	nanoparticle	NOUN
bionys-589	110	46	were	be	AUX
bionys-589	110	47	measured	measure	VERB
bionys-589	110	48	using	use	VERB
bionys-589	110	49	the	the	DET
bionys-589	110	50	dls	dls	NOUN
bionys-589	110	51	technique	technique	NOUN
bionys-589	110	52	and	and	CCONJ
bionys-589	110	53	a	a	DET
bionys-589	110	54	computerized	computerized	ADJ
bionys-589	110	55	zetasizer	zetasizer	NOUN
bionys-589	110	56	.	.	PUNCT
bionys-589	111	1	a	a	DET
bionys-589	111	2	zetasizer	zetasizer	NOUN
bionys-589	111	3	cell	cell	NOUN
bionys-589	111	4	was	be	AUX
bionys-589	111	5	loaded	load	VERB
bionys-589	111	6	with	with	ADP
bionys-589	111	7	nanoformulation	nanoformulation	NOUN
bionys-589	111	8	,	,	PUNCT
bionys-589	111	9	and	and	CCONJ
bionys-589	111	10	the	the	DET
bionys-589	111	11	measurements	measurement	NOUN
bionys-589	111	12	were	be	AUX
bionys-589	111	13	taken	take	VERB
bionys-589	111	14	.	.	PUNCT
bionys-589	112	1	values	value	NOUN
bionys-589	112	2	of	of	ADP
bionys-589	112	3	all	all	DET
bionys-589	112	4	particle	particle	NOUN
bionys-589	112	5	sizes	size	NOUN
bionys-589	112	6	in	in	ADP
bionys-589	112	7	the	the	DET
bionys-589	112	8	different	different	ADJ
bionys-589	112	9	formulations	formulation	NOUN
bionys-589	112	10	(	(	PUNCT
bionys-589	112	11	tab	tab	NOUN
bionys-589	112	12	.	.	NOUN
bionys-589	112	13	1	1	NUM
bionys-589	112	14	)	)	PUNCT
bionys-589	112	15	were	be	AUX
bionys-589	112	16	at	at	ADP
bionys-589	112	17	the	the	DET
bionys-589	112	18	nanometer	nanometer	NOUN
bionys-589	112	19	scale	scale	NOUN
bionys-589	112	20	.	.	PUNCT
bionys-589	113	1	particle	particle	NOUN
bionys-589	113	2	size	size	NOUN
bionys-589	113	3	,	,	PUNCT
bionys-589	113	4	zeta	zeta	NOUN
bionys-589	113	5	potential	potential	NOUN
bionys-589	113	6	,	,	PUNCT
bionys-589	113	7	and	and	CCONJ
bionys-589	113	8	pdi	pdi	NOUN
bionys-589	113	9	for	for	ADP
bionys-589	113	10	formulation	formulation	NOUN
bionys-589	113	11	f7	f7	PROPN
bionys-589	113	12	(	(	PUNCT
bionys-589	113	13	fig	fig	NOUN
bionys-589	113	14	.	.	PUNCT
bionys-589	114	1	1a	1a	NOUN
bionys-589	114	2	,	,	PUNCT
bionys-589	114	3	fig	fig	NOUN
bionys-589	114	4	.	.	PUNCT
bionys-589	115	1	1b	1b	NUM
bionys-589	115	2	)	)	PUNCT
bionys-589	116	1	were	be	AUX
bionys-589	116	2	257.8	257.8	NUM
bionys-589	116	3	nm	nm	NOUN
bionys-589	116	4	,	,	PUNCT
bionys-589	116	5	-29	-29	PROPN
bionys-589	116	6	mv	mv	PROPN
bionys-589	116	7	,	,	PUNCT
bionys-589	116	8	and	and	CCONJ
bionys-589	116	9	0.05	0.05	NUM
bionys-589	116	10	,	,	PUNCT
bionys-589	116	11	respectively	respectively	ADV
bionys-589	116	12	.	.	PUNCT
bionys-589	117	1	the	the	DET
bionys-589	117	2	size	size	NOUN
bionys-589	117	3	of	of	ADP
bionys-589	117	4	the	the	DET
bionys-589	117	5	nanoparticles	nanoparticle	NOUN
bionys-589	117	6	was	be	AUX
bionys-589	117	7	255.5	255.5	NUM
bionys-589	117	8	nm	nm	NOUN
bionys-589	117	9	to	to	PART
bionys-589	117	10	facilitate	facilitate	VERB
bionys-589	117	11	uptake	uptake	ADJ
bionys-589	117	12	into	into	ADP
bionys-589	117	13	the	the	DET
bionys-589	117	14	cell	cell	NOUN
bionys-589	117	15	and	and	CCONJ
bionys-589	117	16	delivery	delivery	NOUN
bionys-589	117	17	to	to	ADP
bionys-589	117	18	the	the	DET
bionys-589	117	19	appropriate	appropriate	ADJ
bionys-589	117	20	site	site	NOUN
bionys-589	117	21	.	.	PUNCT
bionys-589	118	1	another	another	DET
bionys-589	118	2	important	important	ADJ
bionys-589	118	3	characteristic	characteristic	ADJ
bionys-589	118	4	parameter	parameter	NOUN
bionys-589	118	5	of	of	ADP
bionys-589	118	6	nanoparticles	nanoparticle	NOUN
bionys-589	118	7	is	be	AUX
bionys-589	118	8	pdi	pdi	ADJ
bionys-589	118	9	.	.	PUNCT
bionys-589	119	1	for	for	ADP
bionys-589	119	2	example	example	NOUN
bionys-589	119	3	,	,	PUNCT
bionys-589	119	4	a	a	DET
bionys-589	119	5	pdi	pdi	NOUN
bionys-589	119	6	below	below	ADP
bionys-589	119	7	0.05	0.05	NUM
bionys-589	119	8	shows	show	NOUN
bionys-589	119	9	that	that	SCONJ
bionys-589	119	10	the	the	DET
bionys-589	119	11	population	population	NOUN
bionys-589	119	12	is	be	AUX
bionys-589	119	13	very	very	ADV
bionys-589	119	14	monodisperse	monodisperse	ADJ
bionys-589	119	15	,	,	PUNCT
bionys-589	119	16	and	and	CCONJ
bionys-589	119	17	a	a	DET
bionys-589	119	18	pdi	pdi	NOUN
bionys-589	119	19	of	of	ADP
bionys-589	119	20	greater	great	ADJ
bionys-589	119	21	than	than	ADP
bionys-589	119	22	0.7	0.7	NUM
bionys-589	119	23	biologica	biologica	PROPN
bionys-589	119	24	nyssana	nyssana	PROPN
bionys-589	120	1	●	●	PUNCT
bionys-589	120	2	16	16	NUM
bionys-589	120	3	(	(	PUNCT
bionys-589	120	4	1	1	NUM
bionys-589	120	5	)	)	PUNCT
bionys-589	120	6	june	june	PROPN
bionys-589	120	7	2025	2025	NUM
bionys-589	120	8	:	:	PUNCT
bionys-589	120	9	267	267	NUM
bionys-589	120	10	-	-	SYM
bionys-589	120	11	276	276	NUM
bionys-589	120	12	alex	alex	PROPN
bionys-589	120	13	et	et	PROPN
bionys-589	120	14	al	al	PROPN
bionys-589	120	15	.	.	PUNCT
bionys-589	120	16	●	●	PUNCT
bionys-589	120	17	formulation	formulation	NOUN
bionys-589	120	18	and	and	CCONJ
bionys-589	120	19	characterization	characterization	NOUN
bionys-589	120	20	of	of	ADP
bionys-589	120	21	nanoparticles	nanoparticle	NOUN
bionys-589	120	22	loaded	load	VERB
bionys-589	120	23	with	with	ADP
bionys-589	120	24	curcumin	curcumin	NOUN
bionys-589	120	25	and	and	CCONJ
bionys-589	120	26	amantadine	amantadine	NOUN
bionys-589	120	27	as	as	ADP
bionys-589	120	28	a	a	DET
bionys-589	120	29	promising	promising	ADJ
bionys-589	120	30	neuroprotective	neuroprotective	ADJ
bionys-589	120	31	agent	agent	NOUN
bionys-589	120	32	fig	fig	NOUN
bionys-589	120	33	.	.	PUNCT
bionys-589	121	1	1	1	X
bionys-589	121	2	.	.	X
bionys-589	121	3	particle	particle	NOUN
bionys-589	121	4	size	size	NOUN
bionys-589	121	5	distribution	distribution	NOUN
bionys-589	121	6	graph	graph	NOUN
bionys-589	121	7	and	and	CCONJ
bionys-589	121	8	zeta	zeta	VERB
bionys-589	121	9	potential	potential	ADJ
bionys-589	121	10	distribution	distribution	NOUN
bionys-589	121	11	graph	graph	NOUN
bionys-589	121	12	of	of	ADP
bionys-589	121	13	f7	f7	PROPN
bionys-589	121	14	formulation	formulation	NOUN
bionys-589	121	15	table	table	NOUN
bionys-589	121	16	1	1	NUM
bionys-589	121	17	.	.	PUNCT
bionys-589	121	18	particle	particle	NOUN
bionys-589	121	19	size	size	NOUN
bionys-589	121	20	,	,	PUNCT
bionys-589	121	21	zeta	zeta	NOUN
bionys-589	121	22	potential	potential	NOUN
bionys-589	121	23	and	and	CCONJ
bionys-589	121	24	pdi	pdi	ADJ
bionys-589	121	25	values	value	NOUN
bionys-589	121	26	of	of	ADP
bionys-589	121	27	optimized	optimize	VERB
bionys-589	121	28	nanoformulation	nanoformulation	NOUN
bionys-589	121	29	formulation	formulation	NOUN
bionys-589	121	30	code	code	NOUN
bionys-589	121	31	particle	particle	NOUN
bionys-589	121	32	size	size	NOUN
bionys-589	121	33	(	(	PUNCT
bionys-589	121	34	nm	nm	NOUN
bionys-589	121	35	)	)	PUNCT
bionys-589	121	36	zeta	zeta	NOUN
bionys-589	121	37	potential	potential	NOUN
bionys-589	121	38	(	(	PUNCT
bionys-589	121	39	mv	mv	NOUN
bionys-589	121	40	)	)	PUNCT
bionys-589	121	41	pdi	pdi	PROPN
bionys-589	121	42	f1	f1	NOUN
bionys-589	121	43	1349	1349	NUM
bionys-589	121	44	-12.6	-12.6	PROPN
bionys-589	121	45	0.13	0.13	NUM
bionys-589	121	46	f2	f2	PROPN
bionys-589	121	47	857.5	857.5	NUM
bionys-589	121	48	-21.4	-21.4	NOUN
bionys-589	121	49	0.71	0.71	NUM
bionys-589	121	50	f3	f3	PROPN
bionys-589	121	51	906.4	906.4	NUM
bionys-589	121	52	-17.7	-17.7	NUM
bionys-589	121	53	0.62	0.62	NUM
bionys-589	121	54	f4	f4	NUM
bionys-589	121	55	589.1	589.1	NUM
bionys-589	121	56	-11.5	-11.5	NUM
bionys-589	121	57	0.91	0.91	NUM
bionys-589	121	58	f5	f5	NOUN
bionys-589	121	59	496.8	496.8	NUM
bionys-589	121	60	-21.6	-21.6	NUM
bionys-589	121	61	0.47	0.47	NUM
bionys-589	121	62	f6	f6	PROPN
bionys-589	121	63	272.4	272.4	NUM
bionys-589	121	64	-28.4	-28.4	NOUN
bionys-589	121	65	0.32	0.32	NUM
bionys-589	121	66	f7	f7	PROPN
bionys-589	121	67	255.5	255.5	NUM
bionys-589	121	68	-29.1	-29.1	NOUN
bionys-589	121	69	0.05	0.05	NUM
bionys-589	121	70	f8	f8	PROPN
bionys-589	121	71	257.8	257.8	NUM
bionys-589	121	72	-21.4	-21.4	NOUN
bionys-589	121	73	0.52	0.52	NUM
bionys-589	121	74	means	mean	VERB
bionys-589	121	75	the	the	DET
bionys-589	121	76	size	size	NOUN
bionys-589	121	77	distribution	distribution	NOUN
bionys-589	121	78	is	be	AUX
bionys-589	121	79	wide	wide	ADJ
bionys-589	121	80	.	.	PUNCT
bionys-589	122	1	the	the	DET
bionys-589	122	2	result	result	NOUN
bionys-589	122	3	of	of	ADP
bionys-589	122	4	this	this	DET
bionys-589	122	5	experiment	experiment	NOUN
bionys-589	122	6	also	also	ADV
bionys-589	122	7	indicated	indicate	VERB
bionys-589	122	8	a	a	DET
bionys-589	122	9	pdi	pdi	NOUN
bionys-589	122	10	of	of	ADP
bionys-589	122	11	0.05	0.05	NUM
bionys-589	122	12	,	,	PUNCT
bionys-589	122	13	signifying	signify	VERB
bionys-589	122	14	no	no	DET
bionys-589	122	15	significant	significant	ADJ
bionys-589	122	16	variation	variation	NOUN
bionys-589	122	17	in	in	ADP
bionys-589	122	18	particle	particle	NOUN
bionys-589	122	19	sizes	size	NOUN
bionys-589	122	20	,	,	PUNCT
bionys-589	122	21	along	along	ADP
bionys-589	122	22	with	with	ADP
bionys-589	122	23	a	a	DET
bionys-589	122	24	zeta	zeta	NOUN
bionys-589	122	25	potential	potential	NOUN
bionys-589	122	26	of	of	ADP
bionys-589	122	27	-29	-29	PROPN
bionys-589	122	28	mv	mv	PROPN
bionys-589	122	29	that	that	PRON
bionys-589	122	30	is	be	AUX
bionys-589	122	31	adequate	adequate	ADJ
bionys-589	122	32	electrostatic	electrostatic	ADJ
bionys-589	122	33	repulsion	repulsion	NOUN
bionys-589	122	34	,	,	PUNCT
bionys-589	122	35	stabilizing	stabilize	VERB
bionys-589	122	36	the	the	DET
bionys-589	122	37	suspension	suspension	NOUN
bionys-589	122	38	and	and	CCONJ
bionys-589	122	39	preventing	prevent	VERB
bionys-589	122	40	agglomeration	agglomeration	NOUN
bionys-589	122	41	of	of	ADP
bionys-589	122	42	the	the	DET
bionys-589	122	43	particles	particle	NOUN
bionys-589	122	44	.	.	PUNCT
bionys-589	123	1	although	although	SCONJ
bionys-589	123	2	the	the	DET
bionys-589	123	3	particle	particle	NOUN
bionys-589	123	4	size	size	NOUN
bionys-589	123	5	of	of	ADP
bionys-589	123	6	257.8	257.8	NUM
bionys-589	123	7	nm	nm	NOUN
bionys-589	123	8	may	may	AUX
bionys-589	123	9	seem	seem	VERB
bionys-589	123	10	relatively	relatively	ADV
bionys-589	123	11	large	large	ADJ
bionys-589	123	12	,	,	PUNCT
bionys-589	123	13	it	it	PRON
bionys-589	123	14	falls	fall	VERB
bionys-589	123	15	within	within	ADP
bionys-589	123	16	the	the	DET
bionys-589	123	17	optimal	optimal	ADJ
bionys-589	123	18	range	range	NOUN
bionys-589	123	19	(	(	PUNCT
bionys-589	123	20	100–300	100–300	NUM
bionys-589	123	21	nm	nm	NOUN
bionys-589	123	22	)	)	PUNCT
bionys-589	123	23	for	for	ADP
bionys-589	123	24	effective	effective	ADJ
bionys-589	123	25	brain	brain	NOUN
bionys-589	123	26	-	-	PUNCT
bionys-589	123	27	targeted	target	VERB
bionys-589	123	28	delivery	delivery	NOUN
bionys-589	123	29	.	.	PUNCT
bionys-589	124	1	such	such	ADJ
bionys-589	124	2	sizes	size	NOUN
bionys-589	124	3	are	be	AUX
bionys-589	124	4	known	know	VERB
bionys-589	124	5	to	to	PART
bionys-589	124	6	cross	cross	VERB
bionys-589	124	7	the	the	DET
bionys-589	124	8	blood	blood	NOUN
bionys-589	124	9	-	-	PUNCT
bionys-589	124	10	brain	brain	NOUN
bionys-589	124	11	barrier	barrier	NOUN
bionys-589	124	12	via	via	ADP
bionys-589	124	13	transcytosis	transcytosis	NOUN
bionys-589	124	14	mechanisms	mechanism	NOUN
bionys-589	124	15	.	.	PUNCT
bionys-589	125	1	additionally	additionally	ADV
bionys-589	125	2	,	,	PUNCT
bionys-589	125	3	the	the	DET
bionys-589	125	4	narrow	narrow	ADJ
bionys-589	125	5	pdi	pdi	NOUN
bionys-589	125	6	(	(	PUNCT
bionys-589	125	7	0.05	0.05	NUM
bionys-589	125	8	)	)	PUNCT
bionys-589	125	9	and	and	CCONJ
bionys-589	125	10	stable	stable	ADJ
bionys-589	125	11	zeta	zeta	NOUN
bionys-589	125	12	potential	potential	NOUN
bionys-589	125	13	(	(	PUNCT
bionys-589	125	14	–	–	PUNCT
bionys-589	125	15	29	29	NUM
bionys-589	125	16	mv	mv	NOUN
bionys-589	125	17	)	)	PUNCT
bionys-589	125	18	indicate	indicate	VERB
bionys-589	125	19	a	a	DET
bionys-589	125	20	uniform	uniform	ADJ
bionys-589	125	21	and	and	CCONJ
bionys-589	125	22	stable	stable	ADJ
bionys-589	125	23	formulation	formulation	NOUN
bionys-589	125	24	.	.	PUNCT
bionys-589	126	1	larger	large	ADJ
bionys-589	126	2	nanoparticles	nanoparticle	NOUN
bionys-589	126	3	in	in	ADP
bionys-589	126	4	this	this	DET
bionys-589	126	5	range	range	NOUN
bionys-589	126	6	can	can	AUX
bionys-589	126	7	also	also	ADV
bionys-589	126	8	offer	offer	VERB
bionys-589	126	9	advantages	advantage	NOUN
bionys-589	126	10	such	such	ADJ
bionys-589	126	11	as	as	ADP
bionys-589	126	12	higher	high	ADJ
bionys-589	126	13	drug	drug	NOUN
bionys-589	126	14	-	-	PUNCT
bionys-589	126	15	loading	loading	NOUN
bionys-589	126	16	capacity	capacity	NOUN
bionys-589	126	17	and	and	CCONJ
bionys-589	126	18	sustained	sustained	ADJ
bionys-589	126	19	release	release	NOUN
bionys-589	126	20	,	,	PUNCT
bionys-589	126	21	which	which	PRON
bionys-589	126	22	are	be	AUX
bionys-589	126	23	beneficial	beneficial	ADJ
bionys-589	126	24	for	for	ADP
bionys-589	126	25	neuroprotective	neuroprotective	ADJ
bionys-589	126	26	applications	application	NOUN
bionys-589	126	27	.	.	PUNCT
bionys-589	127	1	entrapment	entrapment	ADJ
bionys-589	127	2	efficiency	efficiency	NOUN
bionys-589	127	3	the	the	DET
bionys-589	127	4	entrapment	entrapment	ADJ
bionys-589	127	5	efficiency	efficiency	NOUN
bionys-589	127	6	of	of	ADP
bionys-589	127	7	the	the	DET
bionys-589	127	8	formulation	formulation	NOUN
bionys-589	127	9	is	be	AUX
bionys-589	127	10	based	base	VERB
bionys-589	127	11	on	on	ADP
bionys-589	127	12	the	the	DET
bionys-589	127	13	properties	property	NOUN
bionys-589	127	14	of	of	ADP
bionys-589	127	15	the	the	DET
bionys-589	127	16	polymer	polymer	NOUN
bionys-589	127	17	,	,	PUNCT
bionys-589	127	18	drug	drug	NOUN
bionys-589	127	19	,	,	PUNCT
bionys-589	127	20	and	and	CCONJ
bionys-589	127	21	desolvating	desolvate	VERB
bionys-589	127	22	agent	agent	NOUN
bionys-589	127	23	.	.	PUNCT
bionys-589	128	1	the	the	DET
bionys-589	128	2	prepared	prepare	VERB
bionys-589	128	3	nanoparticles	nanoparticle	NOUN
bionys-589	128	4	were	be	AUX
bionys-589	128	5	investigated	investigate	VERB
bionys-589	128	6	using	use	VERB
bionys-589	128	7	a	a	DET
bionys-589	128	8	refrigerated	refrigerate	VERB
bionys-589	128	9	centrifuge	centrifuge	NOUN
bionys-589	128	10	method	method	NOUN
bionys-589	128	11	to	to	PART
bionys-589	128	12	determine	determine	VERB
bionys-589	128	13	this	this	DET
bionys-589	128	14	parameter	parameter	NOUN
bionys-589	128	15	.	.	PUNCT
bionys-589	129	1	the	the	DET
bionys-589	129	2	nanoparticles	nanoparticle	NOUN
bionys-589	129	3	271	271	NUM
bionys-589	129	4	biologica	biologica	PROPN
bionys-589	129	5	nyssana	nyssana	PROPN
bionys-589	129	6	●	●	PUNCT
bionys-589	129	7	16	16	NUM
bionys-589	129	8	(	(	PUNCT
bionys-589	129	9	1	1	NUM
bionys-589	129	10	)	)	PUNCT
bionys-589	129	11	june	june	PROPN
bionys-589	129	12	2025	2025	NUM
bionys-589	129	13	:	:	PUNCT
bionys-589	129	14	267	267	NUM
bionys-589	129	15	-	-	SYM
bionys-589	129	16	276	276	NUM
bionys-589	129	17	alex	alex	PROPN
bionys-589	129	18	et	et	PROPN
bionys-589	129	19	al	al	PROPN
bionys-589	129	20	.	.	PUNCT
bionys-589	130	1	●	●	PUNCT
bionys-589	130	2	formulation	formulation	NOUN
bionys-589	130	3	and	and	CCONJ
bionys-589	130	4	characterization	characterization	NOUN
bionys-589	130	5	of	of	ADP
bionys-589	130	6	nanoparticles	nanoparticle	NOUN
bionys-589	130	7	loaded	load	VERB
bionys-589	130	8	with	with	ADP
bionys-589	130	9	curcumin	curcumin	NOUN
bionys-589	130	10	and	and	CCONJ
bionys-589	130	11	amantadine	amantadine	NOUN
bionys-589	130	12	as	as	ADP
bionys-589	130	13	a	a	DET
bionys-589	130	14	promising	promising	ADJ
bionys-589	130	15	neuroprotective	neuroprotective	ADJ
bionys-589	130	16	agent	agent	NOUN
bionys-589	130	17	were	be	AUX
bionys-589	130	18	centrifuged	centrifuge	VERB
bionys-589	130	19	at	at	ADP
bionys-589	130	20	3000	3000	NUM
bionys-589	130	21	rpm	rpm	NOUN
bionys-589	130	22	for	for	ADP
bionys-589	130	23	30	30	NUM
bionys-589	130	24	minutes	minute	NOUN
bionys-589	130	25	.	.	PUNCT
bionys-589	131	1	the	the	DET
bionys-589	131	2	supernatant	supernatant	NOUN
bionys-589	131	3	,	,	PUNCT
bionys-589	131	4	containing	contain	VERB
bionys-589	131	5	the	the	DET
bionys-589	131	6	un	un	PROPN
bionys-589	131	7	-	-	ADJ
bionys-589	131	8	entrapped	entrap	VERB
bionys-589	131	9	drug	drug	NOUN
bionys-589	131	10	,	,	PUNCT
bionys-589	131	11	was	be	AUX
bionys-589	131	12	collected	collect	VERB
bionys-589	131	13	and	and	CCONJ
bionys-589	131	14	quantified	quantify	VERB
bionys-589	131	15	using	use	VERB
bionys-589	131	16	a	a	DET
bionys-589	131	17	uv	uv	NOUN
bionys-589	131	18	spectrophotometer	spectrophotometer	NOUN
bionys-589	131	19	at	at	ADP
bionys-589	131	20	a	a	DET
bionys-589	131	21	wavelength	wavelength	NOUN
bionys-589	131	22	of	of	ADP
bionys-589	131	23	425	425	NUM
bionys-589	131	24	nm	nm	NOUN
bionys-589	131	25	(	(	PUNCT
bionys-589	131	26	fig	fig	NOUN
bionys-589	131	27	.	.	PUNCT
bionys-589	132	1	2	2	NUM
bionys-589	132	2	)	)	PUNCT
bionys-589	132	3	.	.	PUNCT
bionys-589	133	1	the	the	DET
bionys-589	133	2	entrapment	entrapment	ADJ
bionys-589	133	3	efficiency	efficiency	NOUN
bionys-589	133	4	across	across	ADP
bionys-589	133	5	all	all	DET
bionys-589	133	6	batches	batch	NOUN
bionys-589	133	7	varied	vary	VERB
bionys-589	133	8	between	between	ADP
bionys-589	133	9	45.61	45.61	NUM
bionys-589	133	10	%	%	NOUN
bionys-589	133	11	and	and	CCONJ
bionys-589	133	12	72.92	72.92	NUM
bionys-589	133	13	%	%	NOUN
bionys-589	133	14	,	,	PUNCT
bionys-589	133	15	with	with	ADP
bionys-589	133	16	formulation	formulation	NOUN
bionys-589	133	17	f7	f7	PROPN
bionys-589	133	18	showing	show	VERB
bionys-589	133	19	the	the	DET
bionys-589	133	20	highest	high	ADJ
bionys-589	133	21	efficiency	efficiency	NOUN
bionys-589	133	22	.	.	PUNCT
bionys-589	134	1	the	the	DET
bionys-589	134	2	high	high	ADJ
bionys-589	134	3	entrapment	entrapment	ADJ
bionys-589	134	4	efficiency	efficiency	NOUN
bionys-589	134	5	of	of	ADP
bionys-589	134	6	72.92	72.92	NUM
bionys-589	134	7	%	%	NOUN
bionys-589	134	8	indicates	indicate	VERB
bionys-589	134	9	significant	significant	ADJ
bionys-589	134	10	drug	drug	NOUN
bionys-589	134	11	loading	loading	NOUN
bionys-589	134	12	,	,	PUNCT
bionys-589	134	13	suggesting	suggest	VERB
bionys-589	134	14	that	that	SCONJ
bionys-589	134	15	this	this	DET
bionys-589	134	16	formulation	formulation	NOUN
bionys-589	134	17	has	have	VERB
bionys-589	134	18	excellent	excellent	ADJ
bionys-589	134	19	potential	potential	NOUN
bionys-589	134	20	for	for	ADP
bionys-589	134	21	achieving	achieve	VERB
bionys-589	134	22	a	a	DET
bionys-589	134	23	good	good	ADJ
bionys-589	134	24	therapeutic	therapeutic	ADJ
bionys-589	134	25	payload	payload	NOUN
bionys-589	134	26	.	.	PUNCT
bionys-589	135	1	high	high	ADJ
bionys-589	135	2	concentrations	concentration	NOUN
bionys-589	135	3	of	of	ADP
bionys-589	135	4	polymer	polymer	NOUN
bionys-589	135	5	and	and	CCONJ
bionys-589	135	6	ethanol	ethanol	NOUN
bionys-589	135	7	enhanced	enhance	VERB
bionys-589	135	8	the	the	DET
bionys-589	135	9	entrapment	entrapment	ADJ
bionys-589	135	10	efficiency	efficiency	NOUN
bionys-589	135	11	,	,	PUNCT
bionys-589	135	12	as	as	SCONJ
bionys-589	135	13	the	the	DET
bionys-589	135	14	drug	drug	NOUN
bionys-589	135	15	is	be	AUX
bionys-589	135	16	lipophilic	lipophilic	ADJ
bionys-589	135	17	.	.	PUNCT
bionys-589	136	1	the	the	DET
bionys-589	136	2	increased	increase	VERB
bionys-589	136	3	lipid	lipid	NOUN
bionys-589	136	4	content	content	NOUN
bionys-589	136	5	improved	improve	VERB
bionys-589	136	6	the	the	DET
bionys-589	136	7	solubilization	solubilization	NOUN
bionys-589	136	8	of	of	ADP
bionys-589	136	9	the	the	DET
bionys-589	136	10	lipophilic	lipophilic	ADJ
bionys-589	136	11	drug	drug	NOUN
bionys-589	136	12	,	,	PUNCT
bionys-589	136	13	creating	create	VERB
bionys-589	136	14	additional	additional	ADJ
bionys-589	136	15	space	space	NOUN
bionys-589	136	16	within	within	ADP
bionys-589	136	17	the	the	DET
bionys-589	136	18	matrix	matrix	NOUN
bionys-589	136	19	for	for	ADP
bionys-589	136	20	drug	drug	NOUN
bionys-589	136	21	entrapment	entrapment	NOUN
bionys-589	136	22	.	.	PUNCT
bionys-589	137	1	in	in	ADP
bionys-589	137	2	vitro	vitro	X
bionys-589	137	3	release	release	NOUN
bionys-589	137	4	study	study	NOUN
bionys-589	137	5	the	the	DET
bionys-589	137	6	in	in	X
bionys-589	137	7	vitro	vitro	X
bionys-589	137	8	drug	drug	NOUN
bionys-589	137	9	release	release	NOUN
bionys-589	137	10	profile	profile	NOUN
bionys-589	137	11	of	of	ADP
bionys-589	137	12	the	the	DET
bionys-589	137	13	formulations	formulation	NOUN
bionys-589	137	14	is	be	AUX
bionys-589	137	15	shown	show	VERB
bionys-589	137	16	graphically	graphically	ADV
bionys-589	137	17	.	.	PUNCT
bionys-589	138	1	the	the	DET
bionys-589	138	2	drug	drug	NOUN
bionys-589	138	3	release	release	NOUN
bionys-589	138	4	profiles	profile	NOUN
bionys-589	138	5	indicate	indicate	VERB
bionys-589	138	6	different	different	ADJ
bionys-589	138	7	release	release	NOUN
bionys-589	138	8	rates	rate	NOUN
bionys-589	138	9	over	over	ADP
bionys-589	138	10	a	a	DET
bionys-589	138	11	period	period	NOUN
bionys-589	138	12	of	of	ADP
bionys-589	138	13	8	8	NUM
bionys-589	138	14	hours	hour	NOUN
bionys-589	138	15	.	.	PUNCT
bionys-589	139	1	in	in	ADP
bionys-589	139	2	the	the	DET
bionys-589	139	3	formulations	formulation	NOUN
bionys-589	139	4	,	,	PUNCT
bionys-589	139	5	f1	f1	NOUN
bionys-589	139	6	to	to	ADP
bionys-589	139	7	f5	f5	PROPN
bionys-589	139	8	showed	show	VERB
bionys-589	139	9	relatively	relatively	ADV
bionys-589	139	10	higher	high	ADJ
bionys-589	139	11	cumulative	cumulative	ADJ
bionys-589	139	12	drug	drug	NOUN
bionys-589	139	13	release	release	NOUN
bionys-589	139	14	percentages	percentage	NOUN
bionys-589	139	15	,	,	PUNCT
bionys-589	139	16	and	and	CCONJ
bionys-589	139	17	around	around	ADP
bionys-589	139	18	40–45	40–45	NUM
bionys-589	139	19	%	%	NOUN
bionys-589	139	20	were	be	AUX
bionys-589	139	21	released	release	VERB
bionys-589	139	22	at	at	ADP
bionys-589	139	23	the	the	DET
bionys-589	139	24	end	end	NOUN
bionys-589	139	25	of	of	ADP
bionys-589	139	26	the	the	DET
bionys-589	139	27	study	study	NOUN
bionys-589	139	28	.	.	PUNCT
bionys-589	140	1	formulations	formulation	NOUN
bionys-589	140	2	f6	f6	PROPN
bionys-589	140	3	,	,	PUNCT
bionys-589	140	4	f7	f7	PROPN
bionys-589	140	5	,	,	PUNCT
bionys-589	140	6	and	and	CCONJ
bionys-589	140	7	f8	f8	PROPN
bionys-589	140	8	show	show	VERB
bionys-589	140	9	slow	slow	ADJ
bionys-589	140	10	release	release	NOUN
bionys-589	140	11	,	,	PUNCT
bionys-589	140	12	but	but	CCONJ
bionys-589	140	13	f7	f7	PROPN
bionys-589	140	14	showed	show	VERB
bionys-589	140	15	a	a	DET
bionys-589	140	16	prolonged	prolonged	ADJ
bionys-589	140	17	drug	drug	NOUN
bionys-589	140	18	release	release	NOUN
bionys-589	140	19	profile	profile	NOUN
bionys-589	140	20	,	,	PUNCT
bionys-589	140	21	with	with	ADP
bionys-589	140	22	the	the	DET
bionys-589	140	23	lowest	low	ADJ
bionys-589	140	24	cumulative	cumulative	ADJ
bionys-589	140	25	drug	drug	NOUN
bionys-589	140	26	release	release	NOUN
bionys-589	140	27	among	among	ADP
bionys-589	140	28	all	all	DET
bionys-589	140	29	the	the	DET
bionys-589	140	30	formulations	formulation	NOUN
bionys-589	140	31	.	.	PUNCT
bionys-589	141	1	the	the	DET
bionys-589	141	2	formulation	formulation	NOUN
bionys-589	141	3	composition	composition	NOUN
bionys-589	141	4	of	of	ADP
bionys-589	141	5	f7	f7	PROPN
bionys-589	141	6	would	would	AUX
bionys-589	141	7	be	be	AUX
bionys-589	141	8	responsible	responsible	ADJ
bionys-589	141	9	for	for	ADP
bionys-589	141	10	the	the	DET
bionys-589	141	11	sustained	sustain	VERB
bionys-589	141	12	release	release	NOUN
bionys-589	141	13	behavior	behavior	NOUN
bionys-589	141	14	due	due	ADP
bionys-589	141	15	to	to	ADP
bionys-589	141	16	its	its	PRON
bionys-589	141	17	possible	possible	ADJ
bionys-589	141	18	enhancement	enhancement	NOUN
bionys-589	141	19	of	of	ADP
bionys-589	141	20	drug	drug	NOUN
bionys-589	141	21	encapsulation	encapsulation	NOUN
bionys-589	141	22	and	and	CCONJ
bionys-589	141	23	minimization	minimization	NOUN
bionys-589	141	24	of	of	ADP
bionys-589	141	25	rapid	rapid	ADJ
bionys-589	141	26	diffusion	diffusion	NOUN
bionys-589	141	27	(	(	PUNCT
bionys-589	141	28	fig	fig	NOUN
bionys-589	141	29	.	.	PUNCT
bionys-589	142	1	3	3	NUM
bionys-589	142	2	)	)	PUNCT
bionys-589	142	3	.	.	PUNCT
bionys-589	143	1	such	such	ADJ
bionys-589	143	2	characteristics	characteristic	NOUN
bionys-589	143	3	are	be	AUX
bionys-589	143	4	advantageous	advantageous	ADJ
bionys-589	143	5	for	for	ADP
bionys-589	143	6	controlled	control	VERB
bionys-589	143	7	drug	drug	NOUN
bionys-589	143	8	delivery	delivery	NOUN
bionys-589	143	9	systems	system	NOUN
bionys-589	143	10	in	in	ADP
bionys-589	143	11	ensuring	ensure	VERB
bionys-589	143	12	prolonged	prolong	VERB
bionys-589	143	13	therapeutic	therapeutic	ADJ
bionys-589	143	14	effects	effect	NOUN
bionys-589	143	15	and	and	CCONJ
bionys-589	143	16	reducing	reduce	VERB
bionys-589	143	17	the	the	DET
bionys-589	143	18	number	number	NOUN
bionys-589	143	19	of	of	ADP
bionys-589	143	20	administrations	administration	NOUN
bionys-589	143	21	.	.	PUNCT
bionys-589	144	1	this	this	DET
bionys-589	144	2	highlights	highlight	VERB
bionys-589	144	3	the	the	DET
bionys-589	144	4	significant	significant	ADJ
bionys-589	144	5	role	role	NOUN
bionys-589	144	6	of	of	ADP
bionys-589	144	7	formulation	formulation	NOUN
bionys-589	144	8	variables	variable	NOUN
bionys-589	144	9	in	in	ADP
bionys-589	144	10	adjusting	adjust	VERB
bionys-589	144	11	the	the	DET
bionys-589	144	12	release	release	NOUN
bionys-589	144	13	kinetics	kinetic	NOUN
bionys-589	144	14	to	to	PART
bionys-589	144	15	meet	meet	VERB
bionys-589	144	16	the	the	DET
bionys-589	144	17	therapeutic	therapeutic	ADJ
bionys-589	144	18	requirements	requirement	NOUN
bionys-589	144	19	.	.	PUNCT
bionys-589	145	1	release	release	NOUN
bionys-589	145	2	kinetics	kinetic	NOUN
bionys-589	145	3	study	study	VERB
bionys-589	145	4	the	the	DET
bionys-589	145	5	drug	drug	NOUN
bionys-589	145	6	release	release	NOUN
bionys-589	145	7	is	be	AUX
bionys-589	145	8	in	in	ADP
bionys-589	145	9	zeroorder	zeroorder	NOUN
bionys-589	145	10	kinetics	kinetic	NOUN
bionys-589	145	11	since	since	SCONJ
bionys-589	145	12	the	the	DET
bionys-589	145	13	r²	r²	NOUN
bionys-589	145	14	of	of	ADP
bionys-589	145	15	0.917	0.917	NUM
bionys-589	145	16	shows	show	VERB
bionys-589	145	17	that	that	SCONJ
bionys-589	145	18	it	it	PRON
bionys-589	145	19	is	be	AUX
bionys-589	145	20	constant	constant	ADJ
bionys-589	145	21	with	with	ADP
bionys-589	145	22	time	time	NOUN
bionys-589	145	23	and	and	CCONJ
bionys-589	145	24	does	do	AUX
bionys-589	145	25	not	not	PART
bionys-589	145	26	depend	depend	VERB
bionys-589	145	27	on	on	ADP
bionys-589	145	28	the	the	DET
bionys-589	145	29	drug	drug	NOUN
bionys-589	145	30	concentration	concentration	NOUN
bionys-589	145	31	within	within	ADP
bionys-589	145	32	the	the	DET
bionys-589	145	33	nanoparticles	nanoparticle	NOUN
bionys-589	145	34	;	;	PUNCT
bionys-589	145	35	this	this	DET
bionys-589	145	36	behavior	behavior	NOUN
bionys-589	145	37	displays	display	VERB
bionys-589	145	38	the	the	DET
bionys-589	145	39	system	system	NOUN
bionys-589	145	40	's	's	PART
bionys-589	145	41	controlled	control	VERB
bionys-589	145	42	-	-	PUNCT
bionys-589	145	43	release	release	NOUN
bionys-589	145	44	properties	property	NOUN
bionys-589	145	45	,	,	PUNCT
bionys-589	145	46	such	such	ADJ
bionys-589	145	47	that	that	SCONJ
bionys-589	145	48	it	it	PRON
bionys-589	145	49	offers	offer	VERB
bionys-589	145	50	predictable	predictable	ADJ
bionys-589	145	51	,	,	PUNCT
bionys-589	145	52	consistent	consistent	ADJ
bionys-589	145	53	drug	drug	NOUN
bionys-589	145	54	release	release	NOUN
bionys-589	145	55	and	and	CCONJ
bionys-589	145	56	,	,	PUNCT
bionys-589	145	57	hence	hence	ADV
bionys-589	145	58	,	,	PUNCT
bionys-589	145	59	sustainable	sustainable	ADJ
bionys-589	145	60	therapeutic	therapeutic	ADJ
bionys-589	145	61	levels	level	NOUN
bionys-589	145	62	for	for	ADP
bionys-589	145	63	an	an	DET
bionys-589	145	64	extensive	extensive	ADJ
bionys-589	145	65	period	period	NOUN
bionys-589	145	66	.	.	PUNCT
bionys-589	146	1	this	this	PRON
bionys-589	146	2	suggests	suggest	VERB
bionys-589	146	3	that	that	SCONJ
bionys-589	146	4	the	the	DET
bionys-589	146	5	mechanism	mechanism	NOUN
bionys-589	146	6	is	be	AUX
bionys-589	146	7	diffusioncontrolled	diffusioncontrolle	VERB
bionys-589	146	8	and	and	CCONJ
bionys-589	146	9	further	far	ADV
bionys-589	146	10	indicates	indicate	VERB
bionys-589	146	11	that	that	SCONJ
bionys-589	146	12	the	the	DET
bionys-589	146	13	diffusion	diffusion	NOUN
bionys-589	146	14	in	in	ADP
bionys-589	146	15	the	the	DET
bionys-589	146	16	nanoparticle	nanoparticle	NOUN
bionys-589	146	17	matrix	matrix	NOUN
bionys-589	146	18	controls	control	VERB
bionys-589	146	19	the	the	DET
bionys-589	146	20	release	release	NOUN
bionys-589	146	21	rate	rate	NOUN
bionys-589	146	22	of	of	ADP
bionys-589	146	23	the	the	DET
bionys-589	146	24	drug	drug	NOUN
bionys-589	146	25	rather	rather	ADV
bionys-589	146	26	than	than	ADP
bionys-589	146	27	any	any	DET
bionys-589	146	28	other	other	ADJ
bionys-589	146	29	controlling	controlling	NOUN
bionys-589	146	30	mechanism	mechanism	NOUN
bionys-589	146	31	.	.	PUNCT
bionys-589	147	1	the	the	DET
bionys-589	147	2	r²	r²	NOUN
bionys-589	147	3	value	value	NOUN
bionys-589	147	4	of	of	ADP
bionys-589	147	5	0.9245	0.9245	NUM
bionys-589	147	6	for	for	ADP
bionys-589	147	7	the	the	DET
bionys-589	147	8	higuchi	higuchi	PROPN
bionys-589	147	9	model	model	NOUN
bionys-589	147	10	further	far	ADV
bionys-589	147	11	confirms	confirm	VERB
bionys-589	147	12	this	this	PRON
bionys-589	147	13	since	since	SCONJ
bionys-589	147	14	the	the	DET
bionys-589	147	15	drug	drug	NOUN
bionys-589	147	16	release	release	NOUN
bionys-589	147	17	varies	vary	VERB
bionys-589	147	18	as	as	ADP
bionys-589	147	19	a	a	DET
bionys-589	147	20	square	square	ADJ
bionys-589	147	21	root	root	NOUN
bionys-589	147	22	function	function	NOUN
bionys-589	147	23	of	of	ADP
bionys-589	147	24	time	time	NOUN
bionys-589	147	25	.	.	PUNCT
bionys-589	148	1	the	the	DET
bionys-589	148	2	korsmeyer	korsmeyer	PROPN
bionys-589	148	3	–	–	PUNCT
bionys-589	148	4	peppas	peppas	NOUN
bionys-589	148	5	model	model	NOUN
bionys-589	148	6	with	with	ADP
bionys-589	148	7	an	an	DET
bionys-589	148	8	r²	r²	NOUN
bionys-589	148	9	of	of	ADP
bionys-589	148	10	0.9735	0.9735	NUM
bionys-589	148	11	shows	show	VERB
bionys-589	148	12	a	a	DET
bionys-589	148	13	non	non	ADJ
bionys-589	148	14	-	-	ADJ
bionys-589	148	15	fickian	fickian	ADJ
bionys-589	148	16	or	or	CCONJ
bionys-589	148	17	anomalous	anomalous	ADJ
bionys-589	148	18	release	release	NOUN
bionys-589	148	19	mechanism	mechanism	NOUN
bionys-589	148	20	,	,	PUNCT
bionys-589	148	21	meaning	mean	VERB
bionys-589	148	22	that	that	SCONJ
bionys-589	148	23	drug	drug	NOUN
bionys-589	148	24	release	release	NOUN
bionys-589	148	25	that	that	PRON
bionys-589	148	26	is	be	AUX
bionys-589	148	27	subjected	subject	VERB
bionys-589	148	28	to	to	ADP
bionys-589	148	29	diffusion	diffusion	NOUN
bionys-589	148	30	within	within	ADP
bionys-589	148	31	the	the	DET
bionys-589	148	32	polymeric	polymeric	ADJ
bionys-589	148	33	matrix	matrix	NOUN
bionys-589	148	34	,	,	PUNCT
bionys-589	148	35	along	along	ADP
bionys-589	148	36	with	with	ADP
bionys-589	148	37	the	the	DET
bionys-589	148	38	relaxation	relaxation	NOUN
bionys-589	148	39	of	of	ADP
bionys-589	148	40	polymer	polymer	NOUN
bionys-589	148	41	chains	chain	NOUN
bionys-589	148	42	,	,	PUNCT
bionys-589	148	43	will	will	AUX
bionys-589	148	44	depict	depict	VERB
bionys-589	148	45	such	such	DET
bionys-589	148	46	a	a	DET
bionys-589	148	47	mechanism	mechanism	NOUN
bionys-589	148	48	(	(	PUNCT
bionys-589	148	49	tab	tab	NOUN
bionys-589	148	50	.	.	NOUN
bionys-589	148	51	2	2	NUM
bionys-589	148	52	,	,	PUNCT
bionys-589	148	53	fig	fig	NOUN
bionys-589	148	54	.	.	PUNCT
bionys-589	149	1	3	3	X
bionys-589	149	2	.	.	X
bionys-589	149	3	in	in	ADP
bionys-589	149	4	vitro	vitro	X
bionys-589	149	5	drug	drug	NOUN
bionys-589	149	6	release	release	NOUN
bionys-589	149	7	graph	graph	NOUN
bionys-589	149	8	of	of	ADP
bionys-589	149	9	f1	f1	NOUN
bionys-589	149	10	to	to	ADP
bionys-589	149	11	f8	f8	PROPN
bionys-589	149	12	nanoformulation	nanoformulation	PROPN
bionys-589	149	13	fig	fig	NOUN
bionys-589	149	14	.	.	PUNCT
bionys-589	150	1	2	2	X
bionys-589	150	2	.	.	X
bionys-589	150	3	entrapment	entrapment	ADJ
bionys-589	150	4	efficiency	efficiency	NOUN
bionys-589	150	5	graph	graph	NOUN
bionys-589	150	6	of	of	ADP
bionys-589	150	7	nanoformulations	nanoformulation	NOUN
bionys-589	150	8	272	272	NUM
bionys-589	150	9	biologica	biologica	PROPN
bionys-589	150	10	nyssana	nyssana	PROPN
bionys-589	151	1	●	●	PUNCT
bionys-589	151	2	16	16	NUM
bionys-589	151	3	(	(	PUNCT
bionys-589	151	4	1	1	NUM
bionys-589	151	5	)	)	PUNCT
bionys-589	151	6	june	june	PROPN
bionys-589	151	7	2025	2025	NUM
bionys-589	151	8	:	:	PUNCT
bionys-589	151	9	267	267	NUM
bionys-589	151	10	-	-	SYM
bionys-589	151	11	276	276	NUM
bionys-589	151	12	alex	alex	PROPN
bionys-589	151	13	et	et	PROPN
bionys-589	151	14	al	al	PROPN
bionys-589	151	15	.	.	PUNCT
bionys-589	151	16	●	●	PUNCT
bionys-589	151	17	formulation	formulation	NOUN
bionys-589	151	18	and	and	CCONJ
bionys-589	151	19	characterization	characterization	NOUN
bionys-589	151	20	of	of	ADP
bionys-589	151	21	nanoparticles	nanoparticle	NOUN
bionys-589	151	22	loaded	load	VERB
bionys-589	151	23	with	with	ADP
bionys-589	151	24	curcumin	curcumin	NOUN
bionys-589	151	25	and	and	CCONJ
bionys-589	151	26	amantadine	amantadine	NOUN
bionys-589	151	27	as	as	ADP
bionys-589	151	28	a	a	DET
bionys-589	151	29	promising	promising	ADJ
bionys-589	151	30	neuroprotective	neuroprotective	ADJ
bionys-589	151	31	agent	agent	NOUN
bionys-589	151	32	table	table	NOUN
bionys-589	151	33	2	2	NUM
bionys-589	151	34	.	.	X
bionys-589	151	35	release	release	NOUN
bionys-589	151	36	kinetics	kinetic	NOUN
bionys-589	151	37	of	of	ADP
bionys-589	151	38	f7	f7	PROPN
bionys-589	151	39	formulation	formulation	NOUN
bionys-589	151	40	fig	fig	NOUN
bionys-589	151	41	.	.	PUNCT
bionys-589	151	42	4	4	NUM
bionys-589	151	43	)	)	PUNCT
bionys-589	151	44	.	.	PUNCT
bionys-589	152	1	thus	thus	ADV
bionys-589	152	2	,	,	PUNCT
bionys-589	152	3	it	it	PRON
bionys-589	152	4	exemplifies	exemplify	VERB
bionys-589	152	5	an	an	DET
bionys-589	152	6	interplay	interplay	NOUN
bionys-589	152	7	between	between	ADP
bionys-589	152	8	diffusion	diffusion	NOUN
bionys-589	152	9	-	-	PUNCT
bionys-589	152	10	driven	drive	VERB
bionys-589	152	11	and	and	CCONJ
bionys-589	152	12	matrix	matrix	NOUN
bionys-589	152	13	relaxation	relaxation	NOUN
bionys-589	152	14	-	-	PUNCT
bionys-589	152	15	controlled	control	VERB
bionys-589	152	16	processes	process	NOUN
bionys-589	152	17	,	,	PUNCT
bionys-589	152	18	thereby	thereby	ADV
bionys-589	152	19	offering	offer	VERB
bionys-589	152	20	more	more	ADV
bionys-589	152	21	complex	complex	ADJ
bionys-589	152	22	,	,	PUNCT
bionys-589	152	23	reliable	reliable	ADJ
bionys-589	152	24	drug	drug	NOUN
bionys-589	152	25	delivery	delivery	NOUN
bionys-589	152	26	systems	system	NOUN
bionys-589	152	27	targeted	target	VERB
bionys-589	152	28	for	for	ADP
bionys-589	152	29	sustained	sustained	ADJ
bionys-589	152	30	therapeutic	therapeutic	ADJ
bionys-589	152	31	outcomes	outcome	NOUN
bionys-589	152	32	.	.	PUNCT
bionys-589	153	1	in	in	ADP
bionys-589	153	2	vitro	vitro	X
bionys-589	153	3	neuroprotective	neuroprotective	ADJ
bionys-589	153	4	effect	effect	NOUN
bionys-589	153	5	determination	determination	NOUN
bionys-589	153	6	by	by	ADP
bionys-589	153	7	mtt	mtt	NOUN
bionys-589	153	8	assay	assay	VERB
bionys-589	153	9	the	the	DET
bionys-589	153	10	neuroprotective	neuroprotective	ADJ
bionys-589	153	11	potential	potential	NOUN
bionys-589	153	12	of	of	ADP
bionys-589	153	13	the	the	DET
bionys-589	153	14	sample	sample	NOUN
bionys-589	153	15	combination	combination	NOUN
bionys-589	153	16	(	(	PUNCT
bionys-589	153	17	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	153	18	)	)	PUNCT
bionys-589	153	19	was	be	AUX
bionys-589	153	20	assayed	assay	VERB
bionys-589	153	21	by	by	ADP
bionys-589	153	22	carrying	carry	VERB
bionys-589	153	23	out	out	ADP
bionys-589	153	24	the	the	DET
bionys-589	153	25	mtt	mtt	NOUN
bionys-589	153	26	assay	assay	VERB
bionys-589	153	27	with	with	ADP
bionys-589	153	28	the	the	DET
bionys-589	153	29	neurotoxic	neurotoxic	ADJ
bionys-589	153	30	agent	agent	NOUN
bionys-589	153	31	rotenone	rotenone	NOUN
bionys-589	153	32	.	.	PUNCT
bionys-589	154	1	rotenone	rotenone	NOUN
bionys-589	154	2	was	be	AUX
bionys-589	154	3	selected	select	VERB
bionys-589	154	4	as	as	ADP
bionys-589	154	5	the	the	DET
bionys-589	154	6	neurotoxic	neurotoxic	ADJ
bionys-589	154	7	agent	agent	NOUN
bionys-589	154	8	in	in	ADP
bionys-589	154	9	this	this	DET
bionys-589	154	10	study	study	NOUN
bionys-589	154	11	due	due	ADP
bionys-589	154	12	to	to	ADP
bionys-589	154	13	its	its	PRON
bionys-589	154	14	well	well	ADV
bionys-589	154	15	-	-	PUNCT
bionys-589	154	16	established	establish	VERB
bionys-589	154	17	ability	ability	NOUN
bionys-589	154	18	to	to	PART
bionys-589	154	19	mimic	mimic	VERB
bionys-589	154	20	parkinson	parkinson	NOUN
bionys-589	154	21	’s	’s	PART
bionys-589	154	22	disease	disease	NOUN
bionys-589	154	23	by	by	ADP
bionys-589	154	24	inducing	induce	VERB
bionys-589	154	25	oxidative	oxidative	ADJ
bionys-589	154	26	stress	stress	NOUN
bionys-589	154	27	and	and	CCONJ
bionys-589	154	28	dopaminergic	dopaminergic	ADJ
bionys-589	154	29	neuron	neuron	NOUN
bionys-589	154	30	damage	damage	NOUN
bionys-589	154	31	through	through	ADP
bionys-589	154	32	mitochondrial	mitochondrial	ADJ
bionys-589	154	33	complex	complex	NOUN
bionys-589	154	34	i	i	PRON
bionys-589	154	35	inhibition	inhibition	VERB
bionys-589	154	36	in	in	ADV
bionys-589	154	37	in	in	ADP
bionys-589	154	38	vitro	vitro	X
bionys-589	154	39	and	and	CCONJ
bionys-589	154	40	in	in	ADP
bionys-589	154	41	vivo	vivo	NOUN
bionys-589	154	42	models	model	NOUN
bionys-589	154	43	.	.	PUNCT
bionys-589	155	1	hence	hence	ADV
bionys-589	155	2	,	,	PUNCT
bionys-589	155	3	it	it	PRON
bionys-589	155	4	is	be	AUX
bionys-589	155	5	an	an	DET
bionys-589	155	6	appropriate	appropriate	ADJ
bionys-589	155	7	choice	choice	NOUN
bionys-589	155	8	for	for	ADP
bionys-589	155	9	modeling	model	VERB
bionys-589	155	10	pd	pd	ADJ
bionys-589	155	11	-	-	PUNCT
bionys-589	155	12	related	relate	VERB
bionys-589	155	13	neurotoxicity	neurotoxicity	NOUN
bionys-589	155	14	.	.	PUNCT
bionys-589	156	1	cells	cell	NOUN
bionys-589	156	2	without	without	ADP
bionys-589	156	3	treatment	treatment	NOUN
bionys-589	156	4	were	be	AUX
bionys-589	156	5	kept	keep	VERB
bionys-589	156	6	aside	aside	ADV
bionys-589	156	7	to	to	PART
bionys-589	156	8	control	control	VERB
bionys-589	156	9	.	.	PUNCT
bionys-589	157	1	od	od	NOUN
bionys-589	157	2	values	value	NOUN
bionys-589	157	3	for	for	ADP
bionys-589	157	4	the	the	DET
bionys-589	157	5	diverse	diverse	ADJ
bionys-589	157	6	concentrations	concentration	NOUN
bionys-589	157	7	of	of	ADP
bionys-589	157	8	samples	sample	NOUN
bionys-589	157	9	within	within	ADP
bionys-589	157	10	1.5	1.5	NUM
bionys-589	157	11	to	to	PART
bionys-589	157	12	25	25	NUM
bionys-589	157	13	µg	µg	NOUN
bionys-589	157	14	/	/	SYM
bionys-589	157	15	ml	ml	NOUN
bionys-589	157	16	are	be	AUX
bionys-589	157	17	obtained	obtain	VERB
bionys-589	157	18	,	,	PUNCT
bionys-589	157	19	and	and	CCONJ
bionys-589	157	20	respective	respective	ADJ
bionys-589	157	21	percentages	percentage	NOUN
bionys-589	157	22	of	of	ADP
bionys-589	157	23	cell	cell	NOUN
bionys-589	157	24	viability	viability	NOUN
bionys-589	157	25	are	be	AUX
bionys-589	157	26	calculated	calculate	VERB
bionys-589	157	27	.	.	PUNCT
bionys-589	158	1	the	the	DET
bionys-589	158	2	control	control	PROPN
bionys-589	158	3	group	group	NOUN
bionys-589	158	4	had	have	VERB
bionys-589	158	5	the	the	DET
bionys-589	158	6	highest	high	ADJ
bionys-589	158	7	average	average	ADJ
bionys-589	158	8	od	od	PROPN
bionys-589	158	9	value	value	NOUN
bionys-589	158	10	,	,	PUNCT
bionys-589	158	11	0.8725	0.8725	NUM
bionys-589	158	12	,	,	PUNCT
bionys-589	158	13	which	which	PRON
bionys-589	158	14	means	mean	VERB
bionys-589	158	15	100	100	NUM
bionys-589	158	16	%	%	NOUN
bionys-589	158	17	cell	cell	NOUN
bionys-589	158	18	survival	survival	NOUN
bionys-589	158	19	.	.	PUNCT
bionys-589	159	1	however	however	ADV
bionys-589	159	2	,	,	PUNCT
bionys-589	159	3	rotenone	rotenone	NOUN
bionys-589	159	4	-	-	PUNCT
bionys-589	159	5	treated	treat	VERB
bionys-589	159	6	cells	cell	NOUN
bionys-589	159	7	displayed	display	VERB
bionys-589	159	8	a	a	DET
bionys-589	159	9	drastic	drastic	ADJ
bionys-589	159	10	reduction	reduction	NOUN
bionys-589	159	11	in	in	ADP
bionys-589	159	12	viability	viability	NOUN
bionys-589	159	13	,	,	PUNCT
bionys-589	159	14	and	and	CCONJ
bionys-589	159	15	the	the	DET
bionys-589	159	16	average	average	ADJ
bionys-589	159	17	od	od	PROPN
bionys-589	159	18	value	value	NOUN
bionys-589	159	19	was	be	AUX
bionys-589	159	20	0.4179	0.4179	NUM
bionys-589	159	21	,	,	PUNCT
bionys-589	159	22	which	which	PRON
bionys-589	159	23	translated	translate	VERB
bionys-589	159	24	to	to	ADP
bionys-589	159	25	47.90	47.90	NUM
bionys-589	159	26	%	%	NOUN
bionys-589	159	27	.	.	PUNCT
bionys-589	160	1	this	this	PRON
bionys-589	160	2	confirms	confirm	VERB
bionys-589	160	3	the	the	DET
bionys-589	160	4	potent	potent	ADJ
bionys-589	160	5	neurotoxic	neurotoxic	ADJ
bionys-589	160	6	effect	effect	NOUN
bionys-589	160	7	of	of	ADP
bionys-589	160	8	rotenone	rotenone	NOUN
bionys-589	160	9	.	.	PUNCT
bionys-589	161	1	the	the	DET
bionys-589	161	2	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	161	3	formulation	formulation	NOUN
bionys-589	161	4	increased	increase	VERB
bionys-589	161	5	the	the	DET
bionys-589	161	6	cell	cell	NOUN
bionys-589	161	7	viability	viability	NOUN
bionys-589	161	8	in	in	ADP
bionys-589	161	9	a	a	DET
bionys-589	161	10	concentration	concentration	NOUN
bionys-589	161	11	-	-	PUNCT
bionys-589	161	12	dependent	dependent	ADJ
bionys-589	161	13	manner	manner	NOUN
bionys-589	161	14	.	.	PUNCT
bionys-589	162	1	the	the	DET
bionys-589	162	2	sample	sample	NOUN
bionys-589	162	3	with	with	ADP
bionys-589	162	4	the	the	DET
bionys-589	162	5	lowest	low	ADJ
bionys-589	162	6	concentration	concentration	NOUN
bionys-589	162	7	of	of	ADP
bionys-589	162	8	1.5	1.5	NUM
bionys-589	162	9	µg	µg	NOUN
bionys-589	162	10	/	/	SYM
bionys-589	162	11	ml	ml	NOUN
bionys-589	162	12	had	have	VERB
bionys-589	162	13	an	an	DET
bionys-589	162	14	average	average	ADJ
bionys-589	162	15	od	od	NOUN
bionys-589	162	16	of	of	ADP
bionys-589	162	17	0.4703	0.4703	NUM
bionys-589	162	18	and	and	CCONJ
bionys-589	162	19	a	a	DET
bionys-589	162	20	model	model	NOUN
bionys-589	162	21	name	name	NOUN
bionys-589	162	22	zero	zero	NUM
bionys-589	162	23	order	order	NOUN
bionys-589	162	24	kinetics	kinetic	VERB
bionys-589	162	25	first	first	ADJ
bionys-589	162	26	order	order	NOUN
bionys-589	162	27	kinetics	kinetic	VERB
bionys-589	162	28	higuchi	higuchi	PROPN
bionys-589	162	29	model	model	PROPN
bionys-589	162	30	korsmeyer	korsmeyer	PROPN
bionys-589	162	31	peppas	peppas	PROPN
bionys-589	162	32	model	model	NOUN
bionys-589	162	33	r2	r2	PROPN
bionys-589	162	34	value	value	NOUN
bionys-589	162	35	0.917	0.917	NUM
bionys-589	162	36	0.8512	0.8512	NUM
bionys-589	162	37	0.9245	0.9245	NUM
bionys-589	162	38	0.9735	0.9735	NUM
bionys-589	162	39	fig	fig	NOUN
bionys-589	162	40	.	.	PUNCT
bionys-589	163	1	4	4	X
bionys-589	163	2	.	.	X
bionys-589	163	3	release	release	VERB
bionys-589	163	4	kinetics	kinetic	NOUN
bionys-589	163	5	of	of	ADP
bionys-589	163	6	f7	f7	PROPN
bionys-589	163	7	formulation	formulation	NOUN
bionys-589	163	8	(	(	PUNCT
bionys-589	163	9	a	a	DET
bionys-589	163	10	zero	zero	NUM
bionys-589	163	11	order	order	NOUN
bionys-589	163	12	kinetics	kinetic	NOUN
bionys-589	163	13	;	;	PUNCT
bionys-589	163	14	b	b	X
bionys-589	163	15	first	first	ADJ
bionys-589	163	16	order	order	NOUN
bionys-589	163	17	kinetics	kinetic	NOUN
bionys-589	163	18	;	;	PUNCT
bionys-589	163	19	c	c	PROPN
bionys-589	163	20	higuchi	higuchi	PROPN
bionys-589	163	21	plot	plot	NOUN
bionys-589	163	22	;	;	PUNCT
bionys-589	163	23	d	d	PROPN
bionys-589	163	24	korsmeyer	korsmeyer	NOUN
bionys-589	163	25	peppas	peppas	PROPN
bionys-589	163	26	plot	plot	NOUN
bionys-589	163	27	)	)	PUNCT
bionys-589	163	28	273	273	NUM
bionys-589	163	29	biologica	biologica	PROPN
bionys-589	163	30	nyssana	nyssana	PROPN
bionys-589	163	31	●	●	PUNCT
bionys-589	163	32	16	16	NUM
bionys-589	163	33	(	(	PUNCT
bionys-589	163	34	1	1	NUM
bionys-589	163	35	)	)	PUNCT
bionys-589	163	36	june	june	PROPN
bionys-589	163	37	2025	2025	NUM
bionys-589	163	38	:	:	PUNCT
bionys-589	163	39	267	267	NUM
bionys-589	163	40	-	-	SYM
bionys-589	163	41	276	276	NUM
bionys-589	163	42	alex	alex	PROPN
bionys-589	163	43	et	et	PROPN
bionys-589	163	44	al	al	PROPN
bionys-589	163	45	.	.	PUNCT
bionys-589	164	1	●	●	PUNCT
bionys-589	164	2	formulation	formulation	NOUN
bionys-589	164	3	and	and	CCONJ
bionys-589	164	4	characterization	characterization	NOUN
bionys-589	164	5	of	of	ADP
bionys-589	164	6	nanoparticles	nanoparticle	NOUN
bionys-589	164	7	loaded	load	VERB
bionys-589	164	8	with	with	ADP
bionys-589	164	9	curcumin	curcumin	NOUN
bionys-589	164	10	and	and	CCONJ
bionys-589	164	11	amantadine	amantadine	NOUN
bionys-589	164	12	as	as	ADP
bionys-589	164	13	a	a	DET
bionys-589	164	14	promising	promising	ADJ
bionys-589	164	15	neuroprotective	neuroprotective	ADJ
bionys-589	164	16	agent	agent	NOUN
bionys-589	164	17	cell	cell	NOUN
bionys-589	164	18	viability	viability	NOUN
bionys-589	164	19	of	of	ADP
bionys-589	164	20	53.90	53.90	NUM
bionys-589	164	21	%	%	NOUN
bionys-589	164	22	.	.	PUNCT
bionys-589	165	1	a	a	DET
bionys-589	165	2	slight	slight	ADJ
bionys-589	165	3	recovery	recovery	NOUN
bionys-589	165	4	from	from	ADP
bionys-589	165	5	rotenone	rotenone	NOUN
bionys-589	165	6	-	-	PUNCT
bionys-589	165	7	induced	induce	VERB
bionys-589	165	8	cytotoxicity	cytotoxicity	NOUN
bionys-589	165	9	was	be	AUX
bionys-589	165	10	noted	note	VERB
bionys-589	165	11	.	.	PUNCT
bionys-589	166	1	with	with	ADP
bionys-589	166	2	the	the	DET
bionys-589	166	3	increase	increase	NOUN
bionys-589	166	4	to	to	ADP
bionys-589	166	5	3.1	3.1	NUM
bionys-589	166	6	µg	µg	NOUN
bionys-589	166	7	/	/	SYM
bionys-589	166	8	ml	ml	NOUN
bionys-589	166	9	,	,	PUNCT
bionys-589	166	10	the	the	DET
bionys-589	166	11	average	average	NOUN
bionys-589	166	12	od	od	ADV
bionys-589	166	13	became	become	VERB
bionys-589	166	14	0.5484	0.5484	NUM
bionys-589	166	15	,	,	PUNCT
bionys-589	166	16	and	and	CCONJ
bionys-589	166	17	cell	cell	NOUN
bionys-589	166	18	viability	viability	NOUN
bionys-589	166	19	reached	reach	VERB
bionys-589	166	20	62.85	62.85	NUM
bionys-589	166	21	%	%	NOUN
bionys-589	166	22	,	,	PUNCT
bionys-589	166	23	meaning	mean	VERB
bionys-589	166	24	that	that	SCONJ
bionys-589	166	25	the	the	DET
bionys-589	166	26	protective	protective	ADJ
bionys-589	166	27	effect	effect	NOUN
bionys-589	166	28	is	be	AUX
bionys-589	166	29	moderate	moderate	ADJ
bionys-589	166	30	.	.	PUNCT
bionys-589	167	1	the	the	DET
bionys-589	167	2	average	average	ADJ
bionys-589	167	3	od	od	NOUN
bionys-589	167	4	at	at	ADP
bionys-589	167	5	6.25	6.25	NUM
bionys-589	167	6	µg	µg	NOUN
bionys-589	167	7	/	/	SYM
bionys-589	167	8	ml	ml	VERB
bionys-589	167	9	increased	increase	VERB
bionys-589	167	10	further	far	ADV
bionys-589	167	11	to	to	ADP
bionys-589	167	12	0.6011	0.6011	NUM
bionys-589	167	13	,	,	PUNCT
bionys-589	167	14	corresponding	correspond	VERB
bionys-589	167	15	to	to	ADP
bionys-589	167	16	68.90	68.90	NUM
bionys-589	167	17	%	%	NOUN
bionys-589	167	18	cell	cell	NOUN
bionys-589	167	19	viability	viability	NOUN
bionys-589	167	20	.	.	PUNCT
bionys-589	168	1	this	this	DET
bionys-589	168	2	trend	trend	NOUN
bionys-589	168	3	continued	continue	VERB
bionys-589	168	4	well	well	ADV
bionys-589	168	5	up	up	ADP
bionys-589	168	6	to	to	PART
bionys-589	168	7	12.5	12.5	NUM
bionys-589	168	8	µg	µg	NOUN
bionys-589	168	9	/	/	SYM
bionys-589	168	10	ml	ml	NOUN
bionys-589	168	11	,	,	PUNCT
bionys-589	168	12	where	where	SCONJ
bionys-589	168	13	at	at	ADP
bionys-589	168	14	that	that	DET
bionys-589	168	15	concentration	concentration	NOUN
bionys-589	168	16	,	,	PUNCT
bionys-589	168	17	the	the	DET
bionys-589	168	18	average	average	NOUN
bionys-589	168	19	od	od	ADV
bionys-589	168	20	reached	reach	VERB
bionys-589	168	21	0.6591	0.6591	NUM
bionys-589	168	22	,	,	PUNCT
bionys-589	168	23	with	with	ADP
bionys-589	168	24	the	the	DET
bionys-589	168	25	equivalence	equivalence	NOUN
bionys-589	168	26	of	of	ADP
bionys-589	168	27	75.54	75.54	NUM
bionys-589	168	28	%	%	NOUN
bionys-589	168	29	viability	viability	NOUN
bionys-589	168	30	.	.	PUNCT
bionys-589	169	1	the	the	DET
bionys-589	169	2	maximal	maximal	ADJ
bionys-589	169	3	protective	protective	ADJ
bionys-589	169	4	effect	effect	NOUN
bionys-589	169	5	was	be	AUX
bionys-589	169	6	obtained	obtain	VERB
bionys-589	169	7	with	with	ADP
bionys-589	169	8	an	an	DET
bionys-589	169	9	average	average	ADJ
bionys-589	169	10	od	od	NOUN
bionys-589	169	11	of	of	ADP
bionys-589	169	12	0.7301	0.7301	NUM
bionys-589	169	13	and	and	CCONJ
bionys-589	169	14	83.68	83.68	NUM
bionys-589	169	15	%	%	NOUN
bionys-589	169	16	cell	cell	NOUN
bionys-589	169	17	viability	viability	NOUN
bionys-589	169	18	,	,	PUNCT
bionys-589	169	19	with	with	ADP
bionys-589	169	20	the	the	DET
bionys-589	169	21	highest	high	ADJ
bionys-589	169	22	concentration	concentration	NOUN
bionys-589	169	23	tested	test	VERB
bionys-589	169	24	being	be	AUX
bionys-589	169	25	at	at	ADP
bionys-589	169	26	25	25	NUM
bionys-589	169	27	µg/	µg/	NOUN
bionys-589	169	28	ml	ml	NOUN
bionys-589	169	29	(	(	PUNCT
bionys-589	169	30	tab	tab	NOUN
bionys-589	169	31	.	.	PUNCT
bionys-589	169	32	3	3	NUM
bionys-589	169	33	)	)	PUNCT
bionys-589	169	34	.	.	PUNCT
bionys-589	170	1	(	(	PUNCT
bionys-589	170	2	od	od	NOUN
bionys-589	170	3	)	)	PUNCT
bionys-589	170	4	,	,	PUNCT
bionys-589	170	5	percentage	percentage	NOUN
bionys-589	170	6	viability	viability	NOUN
bionys-589	170	7	,	,	PUNCT
bionys-589	170	8	standard	standard	ADJ
bionys-589	170	9	deviations	deviation	NOUN
bionys-589	170	10	(	(	PUNCT
bionys-589	170	11	stdev	stdev	NOUN
bionys-589	170	12	)	)	PUNCT
bionys-589	170	13	,	,	PUNCT
bionys-589	170	14	and	and	CCONJ
bionys-589	170	15	standard	standard	ADJ
bionys-589	170	16	error	error	NOUN
bionys-589	170	17	(	(	PUNCT
bionys-589	170	18	se	se	ADJ
bionys-589	170	19	)	)	PUNCT
bionys-589	170	20	.	.	PUNCT
bionys-589	171	1	the	the	DET
bionys-589	171	2	statistics	statistic	NOUN
bionys-589	171	3	that	that	PRON
bionys-589	171	4	accompanied	accompany	VERB
bionys-589	171	5	the	the	DET
bionys-589	171	6	experiment	experiment	NOUN
bionys-589	171	7	verified	verify	VERB
bionys-589	171	8	the	the	DET
bionys-589	171	9	results	result	NOUN
bionys-589	171	10	and	and	CCONJ
bionys-589	171	11	validated	validate	VERB
bionys-589	171	12	the	the	DET
bionys-589	171	13	effectiveness	effectiveness	NOUN
bionys-589	171	14	of	of	ADP
bionys-589	171	15	the	the	DET
bionys-589	171	16	sample	sample	NOUN
bionys-589	171	17	with	with	ADP
bionys-589	171	18	various	various	ADJ
bionys-589	171	19	concentrations	concentration	NOUN
bionys-589	171	20	.	.	PUNCT
bionys-589	172	1	the	the	DET
bionys-589	172	2	control	control	NOUN
bionys-589	172	3	received	receive	VERB
bionys-589	172	4	no	no	DET
bionys-589	172	5	treatment	treatment	NOUN
bionys-589	172	6	,	,	PUNCT
bionys-589	172	7	and	and	CCONJ
bionys-589	172	8	cell	cell	NOUN
bionys-589	172	9	viability	viability	NOUN
bionys-589	172	10	remained	remain	VERB
bionys-589	172	11	100	100	NUM
bionys-589	172	12	%	%	NOUN
bionys-589	172	13	at	at	ADP
bionys-589	172	14	all	all	DET
bionys-589	172	15	the	the	DET
bionys-589	172	16	time	time	NOUN
bionys-589	172	17	points	point	NOUN
bionys-589	172	18	,	,	PUNCT
bionys-589	172	19	with	with	ADP
bionys-589	172	20	an	an	DET
bionys-589	172	21	average	average	ADJ
bionys-589	172	22	od	od	NOUN
bionys-589	172	23	of	of	ADP
bionys-589	172	24	0.8725	0.8725	NUM
bionys-589	172	25	,	,	PUNCT
bionys-589	172	26	showing	show	VERB
bionys-589	172	27	no	no	DET
bionys-589	172	28	variability	variability	NOUN
bionys-589	172	29	(	(	PUNCT
bionys-589	172	30	stdev=0	stdev=0	NOUN
bionys-589	172	31	,	,	PUNCT
bionys-589	172	32	se=0	se=0	NOUN
bionys-589	172	33	)	)	PUNCT
bionys-589	172	34	.	.	PUNCT
bionys-589	173	1	results	result	NOUN
bionys-589	173	2	will	will	AUX
bionys-589	173	3	form	form	VERB
bionys-589	173	4	the	the	DET
bionys-589	173	5	comparison	comparison	NOUN
bionys-589	173	6	control	control	NOUN
bionys-589	173	7	.	.	PUNCT
bionys-589	174	1	the	the	DET
bionys-589	174	2	results	result	NOUN
bionys-589	174	3	from	from	ADP
bionys-589	174	4	cytotoxicity	cytotoxicity	NOUN
bionys-589	174	5	for	for	ADP
bionys-589	174	6	the	the	DET
bionys-589	174	7	samples	sample	NOUN
bionys-589	174	8	that	that	PRON
bionys-589	174	9	were	be	AUX
bionys-589	174	10	treated	treat	VERB
bionys-589	174	11	with	with	ADP
bionys-589	174	12	rotenone	rotenone	NOUN
bionys-589	174	13	showed	show	VERB
bionys-589	174	14	a	a	DET
bionys-589	174	15	very	very	ADV
bionys-589	174	16	high	high	ADJ
bionys-589	174	17	statistical	statistical	ADJ
bionys-589	174	18	significance	significance	NOUN
bionys-589	174	19	for	for	ADP
bionys-589	174	20	the	the	DET
bionys-589	174	21	remaining	remain	VERB
bionys-589	174	22	average	average	ADJ
bionys-589	174	23	percentage	percentage	NOUN
bionys-589	174	24	of	of	ADP
bionys-589	174	25	cell	cell	NOUN
bionys-589	174	26	viability	viability	NOUN
bionys-589	174	27	at	at	ADP
bionys-589	174	28	about	about	ADV
bionys-589	174	29	47.91	47.91	NUM
bionys-589	174	30	%	%	NOUN
bionys-589	174	31	as	as	SCONJ
bionys-589	174	32	opposed	oppose	VERB
bionys-589	174	33	to	to	ADP
bionys-589	174	34	the	the	DET
bionys-589	174	35	control	control	NOUN
bionys-589	174	36	average	average	NOUN
bionys-589	174	37	.	.	PUNCT
bionys-589	175	1	this	this	PRON
bionys-589	175	2	would	would	AUX
bionys-589	175	3	mean	mean	VERB
bionys-589	175	4	table	table	NOUN
bionys-589	175	5	3	3	NUM
bionys-589	175	6	.	.	PUNCT
bionys-589	176	1	od	od	NOUN
bionys-589	176	2	values	value	NOUN
bionys-589	176	3	of	of	ADP
bionys-589	176	4	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	176	5	nanoparticles	nanoparticle	NOUN
bionys-589	176	6	sample	sample	NOUN
bionys-589	176	7	concentration(µg	concentration(µg	NOUN
bionys-589	176	8	/	/	SYM
bionys-589	176	9	ml	ml	NOUN
bionys-589	176	10	)	)	PUNCT
bionys-589	176	11	od	od	NOUN
bionys-589	176	12	value	value	NOUN
bionys-589	177	1	i	i	PROPN
bionys-589	177	2	od	od	PROPN
bionys-589	177	3	value	value	PROPN
bionys-589	177	4	ii	ii	PROPN
bionys-589	177	5	od	od	PROPN
bionys-589	177	6	value	value	PROPN
bionys-589	177	7	iii	iii	NUM
bionys-589	177	8	average	average	ADJ
bionys-589	177	9	od	od	NUM
bionys-589	177	10	percentage	percentage	NOUN
bionys-589	177	11	viability	viability	NOUN
bionys-589	177	12	control	control	NOUN
bionys-589	177	13	0.8748	0.8748	NUM
bionys-589	177	14	0.8817	0.8817	NUM
bionys-589	177	15	0.8609	0.8609	NUM
bionys-589	177	16	0.8725	0.8725	NUM
bionys-589	177	17	100	100	NUM
bionys-589	177	18	rotenone	rotenone	NOUN
bionys-589	177	19	0.4208	0.4208	NUM
bionys-589	177	20	0.4131	0.4131	NUM
bionys-589	177	21	0.4198	0.4198	NUM
bionys-589	177	22	0.4179	0.4179	NUM
bionys-589	177	23	47.9	47.9	NUM
bionys-589	177	24	sample	sample	NOUN
bionys-589	177	25	code	code	NOUN
bionys-589	177	26	:	:	PUNCT
bionys-589	177	27	curcumin	curcumin	NOUN
bionys-589	177	28	+	+	CCONJ
bionys-589	177	29	amantadine	amantadine	NOUN
bionys-589	177	30	1.5	1.5	NUM
bionys-589	177	31	0.4643	0.4643	NUM
bionys-589	177	32	0.4729	0.4729	NUM
bionys-589	177	33	0.4737	0.4737	NUM
bionys-589	177	34	0.4703	0.4703	NUM
bionys-589	177	35	53.9	53.9	NUM
bionys-589	177	36	3.1	3.1	NUM
bionys-589	177	37	0.5514	0.5514	NUM
bionys-589	177	38	0.5413	0.5413	NUM
bionys-589	177	39	0.5525	0.5525	NUM
bionys-589	177	40	0.5484	0.5484	NUM
bionys-589	177	41	62.85	62.85	NUM
bionys-589	177	42	6.25	6.25	NUM
bionys-589	177	43	0.5956	0.5956	NUM
bionys-589	177	44	0.6068	0.6068	NUM
bionys-589	177	45	0.601	0.601	NUM
bionys-589	177	46	0.6011	0.6011	NUM
bionys-589	177	47	68.9	68.9	NUM
bionys-589	177	48	12.5	12.5	NUM
bionys-589	177	49	0.656	0.656	NUM
bionys-589	177	50	0.6639	0.6639	NUM
bionys-589	177	51	0.6574	0.6574	NUM
bionys-589	177	52	0.6591	0.6591	NUM
bionys-589	177	53	75.54	75.54	NUM
bionys-589	177	54	25	25	NUM
bionys-589	177	55	0.7324	0.7324	NUM
bionys-589	177	56	0.7229	0.7229	NUM
bionys-589	177	57	0.7351	0.7351	NUM
bionys-589	177	58	0.7301	0.7301	NUM
bionys-589	177	59	83.68	83.68	NUM
bionys-589	177	60	these	these	DET
bionys-589	177	61	results	result	NOUN
bionys-589	177	62	indicate	indicate	VERB
bionys-589	177	63	that	that	SCONJ
bionys-589	177	64	curcumin	curcumin	NOUN
bionys-589	177	65	and	and	CCONJ
bionys-589	177	66	amantadine	amantadine	NOUN
bionys-589	177	67	formulations	formulation	NOUN
bionys-589	177	68	indeed	indeed	ADV
bionys-589	177	69	possess	possess	VERB
bionys-589	177	70	a	a	DET
bionys-589	177	71	good	good	ADJ
bionys-589	177	72	neuroprotective	neuroprotective	ADJ
bionys-589	177	73	potential	potential	NOUN
bionys-589	177	74	as	as	SCONJ
bionys-589	177	75	they	they	PRON
bionys-589	177	76	rescue	rescue	VERB
bionys-589	177	77	rotenoneinduced	rotenoneinduce	VERB
bionys-589	177	78	cytotoxicity	cytotoxicity	NOUN
bionys-589	177	79	in	in	ADP
bionys-589	177	80	a	a	DET
bionys-589	177	81	concentration	concentration	NOUN
bionys-589	177	82	-	-	PUNCT
bionys-589	177	83	dependent	dependent	ADJ
bionys-589	177	84	manner	manner	NOUN
bionys-589	177	85	.	.	PUNCT
bionys-589	178	1	the	the	DET
bionys-589	178	2	progressive	progressive	ADJ
bionys-589	178	3	increase	increase	NOUN
bionys-589	178	4	in	in	ADP
bionys-589	178	5	percentage	percentage	NOUN
bionys-589	178	6	viability	viability	NOUN
bionys-589	178	7	as	as	ADP
bionys-589	178	8	concentration	concentration	NOUN
bionys-589	178	9	increases	increase	NOUN
bionys-589	178	10	implies	imply	VERB
bionys-589	178	11	that	that	SCONJ
bionys-589	178	12	the	the	DET
bionys-589	178	13	formulation	formulation	NOUN
bionys-589	178	14	could	could	AUX
bionys-589	178	15	perhaps	perhaps	ADV
bionys-589	178	16	neutralize	neutralize	VERB
bionys-589	178	17	oxidative	oxidative	ADJ
bionys-589	178	18	stress	stress	NOUN
bionys-589	178	19	and	and	CCONJ
bionys-589	178	20	neuronal	neuronal	ADJ
bionys-589	178	21	damages	damage	NOUN
bionys-589	178	22	,	,	PUNCT
bionys-589	178	23	probably	probably	ADV
bionys-589	178	24	due	due	ADP
bionys-589	178	25	to	to	ADP
bionys-589	178	26	the	the	DET
bionys-589	178	27	synergism	synergism	NOUN
bionys-589	178	28	of	of	ADP
bionys-589	178	29	curcumin	curcumin	NOUN
bionys-589	178	30	through	through	ADP
bionys-589	178	31	antioxidant	antioxidant	ADJ
bionys-589	178	32	properties	property	NOUN
bionys-589	178	33	and	and	CCONJ
bionys-589	178	34	amantadine	amantadine	NOUN
bionys-589	178	35	's	's	PART
bionys-589	178	36	neuroprotective	neuroprotective	ADJ
bionys-589	178	37	mechanisms	mechanism	NOUN
bionys-589	178	38	.	.	PUNCT
bionys-589	179	1	the	the	DET
bionys-589	179	2	potential	potential	NOUN
bionys-589	179	3	of	of	ADP
bionys-589	179	4	this	this	DET
bionys-589	179	5	combination	combination	NOUN
bionys-589	179	6	of	of	ADP
bionys-589	179	7	therapies	therapy	NOUN
bionys-589	179	8	can	can	AUX
bionys-589	179	9	be	be	AUX
bionys-589	179	10	a	a	DET
bionys-589	179	11	bright	bright	ADJ
bionys-589	179	12	prospect	prospect	NOUN
bionys-589	179	13	as	as	ADP
bionys-589	179	14	a	a	DET
bionys-589	179	15	therapeutic	therapeutic	ADJ
bionys-589	179	16	measure	measure	NOUN
bionys-589	179	17	for	for	ADP
bionys-589	179	18	oxidative	oxidative	ADJ
bionys-589	179	19	stress	stress	NOUN
bionys-589	179	20	-	-	PUNCT
bionys-589	179	21	related	relate	VERB
bionys-589	179	22	and	and	CCONJ
bionys-589	179	23	neuronal	neuronal	ADJ
bionys-589	179	24	damage	damage	NOUN
bionys-589	179	25	-	-	PUNCT
bionys-589	179	26	related	relate	VERB
bionys-589	179	27	neurodegenerative	neurodegenerative	ADJ
bionys-589	179	28	conditions	condition	NOUN
bionys-589	179	29	.	.	PUNCT
bionys-589	180	1	the	the	DET
bionys-589	180	2	findings	finding	NOUN
bionys-589	180	3	suggest	suggest	VERB
bionys-589	180	4	significant	significant	ADJ
bionys-589	180	5	neuroprotective	neuroprotective	ADJ
bionys-589	180	6	effects	effect	NOUN
bionys-589	180	7	of	of	ADP
bionys-589	180	8	the	the	DET
bionys-589	180	9	drug	drug	NOUN
bionys-589	180	10	from	from	ADP
bionys-589	180	11	an	an	DET
bionys-589	180	12	increase	increase	NOUN
bionys-589	180	13	in	in	ADP
bionys-589	180	14	percentage	percentage	NOUN
bionys-589	180	15	viability	viability	NOUN
bionys-589	180	16	and	and	CCONJ
bionys-589	180	17	betterment	betterment	NOUN
bionys-589	180	18	of	of	ADP
bionys-589	180	19	cell	cell	NOUN
bionys-589	180	20	morphology	morphology	NOUN
bionys-589	180	21	.	.	PUNCT
bionys-589	181	1	statistical	statistical	ADJ
bionys-589	181	2	analysis	analysis	NOUN
bionys-589	181	3	of	of	ADP
bionys-589	181	4	in	in	ADP
bionys-589	181	5	vitro	vitro	X
bionys-589	181	6	neuroprotective	neuroprotective	ADJ
bionys-589	181	7	effect	effect	NOUN
bionys-589	181	8	using	use	VERB
bionys-589	181	9	mtt	mtt	NOUN
bionys-589	181	10	assay	assay	VERB
bionys-589	181	11	the	the	DET
bionys-589	181	12	neuroprotective	neuroprotective	ADJ
bionys-589	181	13	activity	activity	NOUN
bionys-589	181	14	of	of	ADP
bionys-589	181	15	the	the	DET
bionys-589	181	16	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	181	17	combination	combination	NOUN
bionys-589	181	18	was	be	AUX
bionys-589	181	19	investigated	investigate	VERB
bionys-589	181	20	on	on	ADP
bionys-589	181	21	the	the	DET
bionys-589	181	22	sh	sh	PROPN
bionys-589	181	23	-	-	PUNCT
bionys-589	181	24	sy5y	sy5y	PROPN
bionys-589	181	25	cell	cell	NOUN
bionys-589	181	26	line	line	NOUN
bionys-589	181	27	.	.	PUNCT
bionys-589	182	1	data	datum	NOUN
bionys-589	182	2	were	be	AUX
bionys-589	182	3	obtained	obtain	VERB
bionys-589	182	4	from	from	ADP
bionys-589	182	5	the	the	DET
bionys-589	182	6	mtt	mtt	NOUN
bionys-589	182	7	assay	assay	VERB
bionys-589	182	8	,	,	PUNCT
bionys-589	182	9	which	which	PRON
bionys-589	182	10	used	use	VERB
bionys-589	182	11	optical	optical	ADJ
bionys-589	182	12	density	density	NOUN
bionys-589	182	13	that	that	PRON
bionys-589	182	14	neurotoxicity	neurotoxicity	NOUN
bionys-589	182	15	would	would	AUX
bionys-589	182	16	have	have	VERB
bionys-589	182	17	a	a	DET
bionys-589	182	18	significantly	significantly	ADV
bionys-589	182	19	high	high	ADJ
bionys-589	182	20	degree	degree	NOUN
bionys-589	182	21	.	.	PUNCT
bionys-589	183	1	the	the	DET
bionys-589	183	2	two	two	NUM
bionys-589	183	3	variables	variable	NOUN
bionys-589	183	4	,	,	PUNCT
bionys-589	183	5	stdev=0.97015	stdev=0.97015	PUNCT
bionys-589	183	6	and	and	CCONJ
bionys-589	183	7	se=0.32338	se=0.32338	PROPN
bionys-589	183	8	illustrate	illustrate	VERB
bionys-589	183	9	the	the	DET
bionys-589	183	10	variation	variation	NOUN
bionys-589	183	11	in	in	ADP
bionys-589	183	12	the	the	DET
bionys-589	183	13	cytotoxicinduced	cytotoxicinduced	ADJ
bionys-589	183	14	response	response	NOUN
bionys-589	183	15	(	(	PUNCT
bionys-589	183	16	tab	tab	NOUN
bionys-589	183	17	.	.	PUNCT
bionys-589	183	18	4	4	NUM
bionys-589	183	19	)	)	PUNCT
bionys-589	183	20	.	.	PUNCT
bionys-589	184	1	in	in	ADP
bionys-589	184	2	this	this	DET
bionys-589	184	3	study	study	NOUN
bionys-589	184	4	,	,	PUNCT
bionys-589	184	5	the	the	DET
bionys-589	184	6	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	184	7	treatment	treatment	NOUN
bionys-589	184	8	demonstrated	demonstrate	VERB
bionys-589	184	9	a	a	DET
bionys-589	184	10	concentration	concentration	NOUN
bionys-589	184	11	-	-	PUNCT
bionys-589	184	12	dependent	dependent	ADJ
bionys-589	184	13	effect	effect	NOUN
bionys-589	184	14	on	on	ADP
bionys-589	184	15	cell	cell	NOUN
bionys-589	184	16	viability	viability	NOUN
bionys-589	184	17	improvement	improvement	NOUN
bionys-589	184	18	.	.	PUNCT
bionys-589	185	1	on	on	ADP
bionys-589	185	2	1.5	1.5	NUM
bionys-589	185	3	µg	µg	NOUN
bionys-589	185	4	/	/	SYM
bionys-589	185	5	ml	ml	NOUN
bionys-589	185	6	,	,	PUNCT
bionys-589	185	7	the	the	DET
bionys-589	185	8	mean	mean	ADJ
bionys-589	185	9	percentage	percentage	NOUN
bionys-589	185	10	viability	viability	NOUN
bionys-589	185	11	was	be	AUX
bionys-589	185	12	53.91	53.91	NUM
bionys-589	185	13	%	%	NOUN
bionys-589	185	14	(	(	PUNCT
bionys-589	185	15	stdev=1.00335	stdev=1.00335	PROPN
bionys-589	185	16	,	,	PUNCT
bionys-589	185	17	se=0.33445	se=0.33445	NOUN
bionys-589	185	18	)	)	PUNCT
bionys-589	185	19	,	,	PUNCT
bionys-589	185	20	representing	represent	VERB
bionys-589	185	21	partial	partial	ADJ
bionys-589	185	22	protection	protection	NOUN
bionys-589	185	23	from	from	ADP
bionys-589	185	24	rotenone	rotenone	NOUN
bionys-589	185	25	-	-	PUNCT
bionys-589	185	26	induced	induce	VERB
bionys-589	185	27	damage	damage	NOUN
bionys-589	185	28	.	.	PUNCT
bionys-589	186	1	successively	successively	ADV
bionys-589	186	2	higher	high	ADJ
bionys-589	186	3	concentrations	concentration	NOUN
bionys-589	186	4	showed	show	VERB
bionys-589	186	5	increasingly	increasingly	ADV
bionys-589	186	6	increased	increase	VERB
bionys-589	186	7	percent	percent	NOUN
bionys-589	186	8	viability	viability	NOUN
bionys-589	186	9	,	,	PUNCT
bionys-589	186	10	such	such	ADJ
bionys-589	186	11	as	as	ADP
bionys-589	186	12	up	up	ADP
bionys-589	186	13	to	to	PART
bionys-589	186	14	3.70	3.70	NUM
bionys-589	186	15	%	%	NOUN
bionys-589	186	16	at	at	ADP
bionys-589	186	17	25	25	NUM
bionys-589	186	18	µg/	µg/	NOUN
bionys-589	186	19	ml	ml	NOUN
bionys-589	186	20	(	(	PUNCT
bionys-589	186	21	stdev=1.69913	stdev=1.69913	PROPN
bionys-589	186	22	,	,	PUNCT
bionys-589	186	23	se=0.56638	se=0.56638	NOUN
bionys-589	186	24	)	)	PUNCT
bionys-589	186	25	.	.	PUNCT
bionys-589	187	1	this	this	DET
bionys-589	187	2	significant	significant	ADJ
bionys-589	187	3	recovery	recovery	NOUN
bionys-589	187	4	reveals	reveal	VERB
bionys-589	187	5	a	a	DET
bionys-589	187	6	synergistic	synergistic	ADJ
bionys-589	187	7	action	action	NOUN
bionys-589	187	8	between	between	ADP
bionys-589	187	9	curcumin	curcumin	NOUN
bionys-589	187	10	and	and	CCONJ
bionys-589	187	11	amantadine	amantadine	NOUN
bionys-589	187	12	against	against	ADP
bionys-589	187	13	neuronal	neuronal	ADJ
bionys-589	187	14	damage	damage	NOUN
bionys-589	187	15	.	.	PUNCT
bionys-589	188	1	the	the	DET
bionys-589	188	2	trend	trend	NOUN
bionys-589	188	3	for	for	ADP
bionys-589	188	4	cell	cell	NOUN
bionys-589	188	5	viability	viability	NOUN
bionys-589	188	6	at	at	ADP
bionys-589	188	7	a	a	DET
bionys-589	188	8	higher	high	ADJ
bionys-589	188	9	concentration	concentration	NOUN
bionys-589	188	10	of	of	ADP
bionys-589	188	11	curcumin+amantadine	curcumin+amantadine	PROPN
bionys-589	188	12	was	be	AUX
bionys-589	188	13	statistically	statistically	ADV
bionys-589	188	14	analyzed	analyze	VERB
bionys-589	188	15	to	to	PART
bionys-589	188	16	determine	determine	VERB
bionys-589	188	17	the	the	DET
bionys-589	188	18	decreasing	decrease	VERB
bionys-589	188	19	variability	variability	NOUN
bionys-589	188	20	at	at	ADP
bionys-589	188	21	intermediate	intermediate	ADJ
bionys-589	188	22	concentrations	concentration	NOUN
bionys-589	188	23	:	:	PUNCT
bionys-589	188	24	6.25	6.25	NUM
bionys-589	188	25	µg/	µg/	NOUN
bionys-589	188	26	ml	ml	NOUN
bionys-589	188	27	,	,	PUNCT
bionys-589	188	28	stdev=0.86632	stdev=0.86632	NOUN
bionys-589	188	29	,	,	PUNCT
bionys-589	188	30	se=0.28877	se=0.28877	ADJ
bionys-589	188	31	;	;	PUNCT
bionys-589	188	32	thus	thus	ADV
bionys-589	188	33	,	,	PUNCT
bionys-589	188	34	there	there	PRON
bionys-589	188	35	may	may	AUX
bionys-589	188	36	be	be	AUX
bionys-589	188	37	uniform	uniform	ADJ
bionys-589	188	38	protection	protection	NOUN
bionys-589	188	39	at	at	ADP
bionys-589	188	40	such	such	ADJ
bionys-589	188	41	doses	dose	NOUN
bionys-589	188	42	.	.	PUNCT
bionys-589	189	1	the	the	DET
bionys-589	189	2	highest	high	ADJ
bionys-589	189	3	dose	dose	NOUN
bionys-589	189	4	,	,	PUNCT
bionys-589	189	5	25	25	NUM
bionys-589	189	6	µg	µg	NOUN
bionys-589	189	7	/	/	SYM
bionys-589	189	8	ml	ml	NOUN
bionys-589	189	9	,	,	PUNCT
bionys-589	189	10	yielded	yield	VERB
bionys-589	189	11	the	the	DET
bionys-589	189	12	highest	high	ADJ
bionys-589	189	13	variability	variability	NOUN
bionys-589	189	14	at	at	ADP
bionys-589	189	15	stdev=1.69913	stdev=1.69913	PROPN
bionys-589	189	16	,	,	PUNCT
bionys-589	189	17	possibly	possibly	ADV
bionys-589	189	18	because	because	SCONJ
bionys-589	189	19	the	the	DET
bionys-589	189	20	high	high	ADJ
bionys-589	189	21	dose	dose	NOUN
bionys-589	189	22	of	of	ADP
bionys-589	189	23	the	the	DET
bionys-589	189	24	sample	sample	NOUN
bionys-589	189	25	triggered	trigger	VERB
bionys-589	189	26	an	an	DET
bionys-589	189	27	increase	increase	NOUN
bionys-589	189	28	in	in	ADP
bionys-589	189	29	metabolic	metabolic	NOUN
bionys-589	189	30	274	274	NUM
bionys-589	189	31	biologica	biologica	NOUN
bionys-589	189	32	nyssana	nyssana	PROPN
bionys-589	190	1	●	●	PUNCT
bionys-589	190	2	16	16	NUM
bionys-589	190	3	(	(	PUNCT
bionys-589	190	4	1	1	NUM
bionys-589	190	5	)	)	PUNCT
bionys-589	190	6	june	june	PROPN
bionys-589	190	7	2025	2025	NUM
bionys-589	190	8	:	:	PUNCT
bionys-589	190	9	267	267	NUM
bionys-589	190	10	-	-	SYM
bionys-589	190	11	276	276	NUM
bionys-589	190	12	alex	alex	PROPN
bionys-589	190	13	et	et	PROPN
bionys-589	190	14	al	al	PROPN
bionys-589	190	15	.	.	PUNCT
bionys-589	190	16	●	●	PUNCT
bionys-589	190	17	formulation	formulation	NOUN
bionys-589	190	18	and	and	CCONJ
bionys-589	190	19	characterization	characterization	NOUN
bionys-589	190	20	of	of	ADP
bionys-589	190	21	nanoparticles	nanoparticle	NOUN
bionys-589	190	22	loaded	load	VERB
bionys-589	190	23	with	with	ADP
bionys-589	190	24	curcumin	curcumin	NOUN
bionys-589	190	25	and	and	CCONJ
bionys-589	190	26	amantadine	amantadine	NOUN
bionys-589	190	27	as	as	ADP
bionys-589	190	28	a	a	DET
bionys-589	190	29	promising	promising	ADJ
bionys-589	190	30	neuroprotective	neuroprotective	ADJ
bionys-589	190	31	agent	agent	NOUN
bionys-589	190	32	activity	activity	NOUN
bionys-589	190	33	and/or	and/or	CCONJ
bionys-589	190	34	variability	variability	NOUN
bionys-589	190	35	in	in	ADP
bionys-589	190	36	cellular	cellular	ADJ
bionys-589	190	37	response	response	NOUN
bionys-589	190	38	.	.	PUNCT
bionys-589	191	1	the	the	DET
bionys-589	191	2	bar	bar	NOUN
bionys-589	191	3	graph	graph	NOUN
bionys-589	191	4	represents	represent	VERB
bionys-589	191	5	the	the	DET
bionys-589	191	6	neuroprotective	neuroprotective	ADJ
bionys-589	191	7	action	action	NOUN
bionys-589	191	8	(	(	PUNCT
bionys-589	191	9	fig	fig	NOUN
bionys-589	191	10	.	.	PUNCT
bionys-589	191	11	5	5	NUM
bionys-589	191	12	)	)	PUNCT
bionys-589	191	13	.	.	PUNCT
bionys-589	192	1	control	control	NOUN
bionys-589	192	2	and	and	CCONJ
bionys-589	192	3	rotenone	rotenone	NOUN
bionys-589	192	4	-	-	PUNCT
bionys-589	192	5	treated	treat	VERB
bionys-589	192	6	samples	sample	NOUN
bionys-589	192	7	are	be	AUX
bionys-589	192	8	two	two	NUM
bionys-589	192	9	extremes	extreme	NOUN
bionys-589	192	10	wherein	wherein	SCONJ
bionys-589	192	11	the	the	DET
bionys-589	192	12	viability	viability	NOUN
bionys-589	192	13	was	be	AUX
bionys-589	192	14	highly	highly	ADV
bionys-589	192	15	different	different	ADJ
bionys-589	192	16	.	.	PUNCT
bionys-589	193	1	the	the	DET
bionys-589	193	2	bars	bar	NOUN
bionys-589	193	3	related	relate	VERB
bionys-589	193	4	to	to	ADP
bionys-589	193	5	curcumin	curcumin	NOUN
bionys-589	193	6	-	-	PUNCT
bionys-589	193	7	amantadinetreated	amantadinetreate	VERB
bionys-589	193	8	samples	sample	NOUN
bionys-589	193	9	represent	represent	VERB
bionys-589	193	10	a	a	DET
bionys-589	193	11	considerable	considerable	ADJ
bionys-589	193	12	positive	positive	ADJ
bionys-589	193	13	trend	trend	NOUN
bionys-589	193	14	in	in	ADP
bionys-589	193	15	the	the	DET
bionys-589	193	16	recovery	recovery	NOUN
bionys-589	193	17	process	process	NOUN
bionys-589	193	18	,	,	PUNCT
bionys-589	193	19	indicating	indicate	VERB
bionys-589	193	20	that	that	SCONJ
bionys-589	193	21	the	the	DET
bionys-589	193	22	increase	increase	NOUN
bionys-589	193	23	is	be	AUX
bionys-589	193	24	concentration	concentration	NOUN
bionys-589	193	25	-	-	PUNCT
bionys-589	193	26	dependent	dependent	ADJ
bionys-589	193	27	.	.	PUNCT
bionys-589	194	1	the	the	DET
bionys-589	194	2	error	error	NOUN
bionys-589	194	3	bars	bar	NOUN
bionys-589	194	4	depict	depict	VERB
bionys-589	194	5	that	that	SCONJ
bionys-589	194	6	at	at	ADP
bionys-589	194	7	middle	middle	ADJ
bionys-589	194	8	concentrations	concentration	NOUN
bionys-589	194	9	(	(	PUNCT
bionys-589	194	10	6.25–12.5	6.25–12.5	NUM
bionys-589	194	11	µg/	µg/	NOUN
bionys-589	194	12	ml	ml	NOUN
bionys-589	194	13	)	)	PUNCT
bionys-589	194	14	,	,	PUNCT
bionys-589	194	15	the	the	DET
bionys-589	194	16	values	value	NOUN
bionys-589	194	17	are	be	AUX
bionys-589	194	18	more	more	ADV
bionys-589	194	19	accurate	accurate	ADJ
bionys-589	194	20	.	.	PUNCT
bionys-589	195	1	statistical	statistical	ADJ
bionys-589	195	2	analysis	analysis	NOUN
bionys-589	195	3	confirms	confirm	VERB
bionys-589	195	4	that	that	SCONJ
bionys-589	195	5	the	the	DET
bionys-589	195	6	neuroprotective	neuroprotective	ADJ
bionys-589	195	7	effects	effect	NOUN
bionys-589	195	8	of	of	ADP
bionys-589	195	9	the	the	DET
bionys-589	195	10	combination	combination	NOUN
bionys-589	195	11	of	of	ADP
bionys-589	195	12	curcumin	curcumin	NOUN
bionys-589	195	13	and	and	CCONJ
bionys-589	195	14	amantadine	amantadine	NOUN
bionys-589	195	15	are	be	AUX
bionys-589	195	16	indeed	indeed	ADV
bionys-589	195	17	dose	dose	NOUN
bionys-589	195	18	-	-	PUNCT
bionys-589	195	19	dependent	dependent	ADJ
bionys-589	195	20	.	.	PUNCT
bionys-589	196	1	percent	percent	NOUN
bionys-589	196	2	viabilities	viability	NOUN
bionys-589	196	3	are	be	AUX
bionys-589	196	4	high	high	ADJ
bionys-589	196	5	regarding	regard	VERB
bionys-589	196	6	protection	protection	NOUN
bionys-589	196	7	against	against	ADP
bionys-589	196	8	cytotoxicity	cytotoxicity	NOUN
bionys-589	196	9	from	from	ADP
bionys-589	196	10	rotenone	rotenone	NOUN
bionys-589	196	11	at	at	ADP
bionys-589	196	12	concentrations	concentration	NOUN
bionys-589	196	13	of	of	ADP
bionys-589	196	14	12.5–25	12.5–25	NUM
bionys-589	196	15	µg	µg	NOUN
bionys-589	196	16	/	/	SYM
bionys-589	196	17	ml	ml	NOUN
bionys-589	196	18	;	;	PUNCT
bionys-589	196	19	data	datum	NOUN
bionys-589	196	20	approach	approach	NOUN
bionys-589	196	21	near	near	ADP
bionys-589	196	22	-	-	PUNCT
bionys-589	196	23	control	control	NOUN
bionys-589	196	24	levels	level	NOUN
bionys-589	196	25	.	.	PUNCT
bionys-589	197	1	the	the	DET
bionys-589	197	2	consistency	consistency	NOUN
bionys-589	197	3	and	and	CCONJ
bionys-589	197	4	reproducibility	reproducibility	NOUN
bionys-589	197	5	of	of	ADP
bionys-589	197	6	these	these	DET
bionys-589	197	7	data	datum	NOUN
bionys-589	197	8	at	at	ADP
bionys-589	197	9	key	key	ADJ
bionys-589	197	10	concentrations	concentration	NOUN
bionys-589	197	11	,	,	PUNCT
bionys-589	197	12	evidenced	evidence	VERB
bionys-589	197	13	by	by	ADP
bionys-589	197	14	low	low	ADJ
bionys-589	197	15	standard	standard	ADJ
bionys-589	197	16	errors	error	NOUN
bionys-589	197	17	,	,	PUNCT
bionys-589	197	18	support	support	VERB
bionys-589	197	19	the	the	DET
bionys-589	197	20	therapeutic	therapeutic	ADJ
bionys-589	197	21	potential	potential	NOUN
bionys-589	197	22	for	for	ADP
bionys-589	197	23	this	this	DET
bionys-589	197	24	combination	combination	NOUN
bionys-589	197	25	(	(	PUNCT
bionys-589	197	26	fig	fig	NOUN
bionys-589	197	27	.	.	PUNCT
bionys-589	198	1	6a-6f	6a-6f	ADJ
bionys-589	198	2	)	)	PUNCT
bionys-589	198	3	.	.	PUNCT
bionys-589	199	1	these	these	DET
bionys-589	199	2	results	result	NOUN
bionys-589	199	3	support	support	VERB
bionys-589	199	4	further	further	ADJ
bionys-589	199	5	exploration	exploration	NOUN
bionys-589	199	6	of	of	ADP
bionys-589	199	7	curcumin	curcumin	NOUN
bionys-589	199	8	and	and	CCONJ
bionys-589	199	9	amantadine	amantadine	NOUN
bionys-589	199	10	as	as	ADP
bionys-589	199	11	a	a	DET
bionys-589	199	12	synergistic	synergistic	ADJ
bionys-589	199	13	neuroprotective	neuroprotective	ADJ
bionys-589	199	14	strategy	strategy	NOUN
bionys-589	199	15	in	in	ADP
bionys-589	199	16	oxidative	oxidative	ADJ
bionys-589	199	17	stress	stress	NOUN
bionys-589	199	18	and	and	CCONJ
bionys-589	199	19	neurodegeneration	neurodegeneration	NOUN
bionys-589	199	20	models	model	NOUN
bionys-589	199	21	.	.	PUNCT
bionys-589	200	1	conclusion	conclusion	NOUN
bionys-589	200	2	in	in	ADP
bionys-589	200	3	this	this	DET
bionys-589	200	4	study	study	NOUN
bionys-589	200	5	,	,	PUNCT
bionys-589	200	6	we	we	PRON
bionys-589	200	7	fabricated	fabricate	VERB
bionys-589	200	8	curcumin	curcumin	NOUN
bionys-589	200	9	and	and	CCONJ
bionys-589	200	10	amantadine	amantadine	NOUN
bionys-589	200	11	nanoparticles	nanoparticle	NOUN
bionys-589	200	12	using	use	VERB
bionys-589	200	13	bovine	bovine	NOUN
bionys-589	200	14	serum	serum	NOUN
bionys-589	200	15	albumin	albumin	PROPN
bionys-589	200	16	(	(	PUNCT
bionys-589	200	17	bsa	bsa	PROPN
bionys-589	200	18	)	)	PUNCT
bionys-589	200	19	as	as	ADP
bionys-589	200	20	a	a	DET
bionys-589	200	21	nanocarrier	nanocarrier	NOUN
bionys-589	200	22	using	use	VERB
bionys-589	200	23	the	the	DET
bionys-589	200	24	desolvation	desolvation	NOUN
bionys-589	200	25	method	method	NOUN
bionys-589	200	26	for	for	ADP
bionys-589	200	27	antiparkinson	antiparkinson	NOUN
bionys-589	200	28	activity	activity	NOUN
bionys-589	200	29	.	.	PUNCT
bionys-589	201	1	eight	eight	NUM
bionys-589	201	2	nanoformulations	nanoformulation	NOUN
bionys-589	201	3	were	be	AUX
bionys-589	201	4	prepared	prepare	VERB
bionys-589	201	5	by	by	ADP
bionys-589	201	6	varying	vary	VERB
bionys-589	201	7	the	the	DET
bionys-589	201	8	concentration	concentration	NOUN
bionys-589	201	9	of	of	ADP
bionys-589	201	10	ethanol	ethanol	NOUN
bionys-589	201	11	,	,	PUNCT
bionys-589	201	12	glutaraldehyde	glutaraldehyde	NOUN
bionys-589	201	13	,	,	PUNCT
bionys-589	201	14	and	and	CCONJ
bionys-589	201	15	stirring	stirring	NOUN
bionys-589	201	16	time	time	NOUN
bionys-589	201	17	.	.	PUNCT
bionys-589	202	1	the	the	DET
bionys-589	202	2	nanoparticles	nanoparticle	NOUN
bionys-589	202	3	were	be	AUX
bionys-589	202	4	acquired	acquire	VERB
bionys-589	202	5	in	in	ADP
bionys-589	202	6	the	the	DET
bionys-589	202	7	particle	particle	NOUN
bionys-589	202	8	size	size	NOUN
bionys-589	202	9	of	of	ADP
bionys-589	202	10	255.5	255.5	NUM
bionys-589	202	11	nm	nm	NOUN
bionys-589	202	12	,	,	PUNCT
bionys-589	202	13	within	within	ADP
bionys-589	202	14	the	the	DET
bionys-589	202	15	optimal	optimal	ADJ
bionys-589	202	16	range	range	NOUN
bionys-589	202	17	for	for	ADP
bionys-589	202	18	cellular	cellular	ADJ
bionys-589	202	19	growth	growth	NOUN
bionys-589	202	20	and	and	CCONJ
bionys-589	202	21	targeted	target	VERB
bionys-589	202	22	delivery	delivery	NOUN
bionys-589	202	23	.	.	PUNCT
bionys-589	203	1	pdi	pdi	PROPN
bionys-589	203	2	was	be	AUX
bionys-589	203	3	found	find	VERB
bionys-589	203	4	to	to	PART
bionys-589	203	5	be	be	AUX
bionys-589	203	6	0.05	0.05	NUM
bionys-589	203	7	,	,	PUNCT
bionys-589	203	8	indicating	indicate	VERB
bionys-589	203	9	a	a	DET
bionys-589	203	10	highly	highly	ADV
bionys-589	203	11	uniform	uniform	ADJ
bionys-589	203	12	size	size	NOUN
bionys-589	203	13	distribution	distribution	NOUN
bionys-589	203	14	,	,	PUNCT
bionys-589	203	15	and	and	CCONJ
bionys-589	203	16	a	a	DET
bionys-589	203	17	zeta	zeta	NOUN
bionys-589	203	18	potential	potential	NOUN
bionys-589	203	19	of	of	ADP
bionys-589	203	20	-29	-29	PROPN
bionys-589	203	21	mv	mv	PROPN
bionys-589	203	22	is	be	AUX
bionys-589	203	23	generally	generally	ADV
bionys-589	203	24	considerably	considerably	ADV
bionys-589	203	25	stable	stable	ADJ
bionys-589	203	26	,	,	PUNCT
bionys-589	203	27	indicating	indicate	VERB
bionys-589	203	28	a	a	DET
bionys-589	203	29	sufficient	sufficient	ADJ
bionys-589	203	30	electrostatic	electrostatic	ADJ
bionys-589	203	31	repulsion	repulsion	NOUN
bionys-589	203	32	between	between	ADP
bionys-589	203	33	particles	particle	NOUN
bionys-589	203	34	to	to	PART
bionys-589	203	35	prevent	prevent	VERB
bionys-589	203	36	aggregation	aggregation	NOUN
bionys-589	203	37	.	.	PUNCT
bionys-589	204	1	nanoparticles	nanoparticle	NOUN
bionys-589	204	2	showed	show	VERB
bionys-589	204	3	a	a	DET
bionys-589	204	4	sustained	sustained	ADJ
bionys-589	204	5	release	release	NOUN
bionys-589	204	6	profile	profile	NOUN
bionys-589	204	7	,	,	PUNCT
bionys-589	204	8	and	and	CCONJ
bionys-589	204	9	both	both	DET
bionys-589	204	10	diffusion	diffusion	NOUN
bionys-589	204	11	and	and	CCONJ
bionys-589	204	12	relaxation	relaxation	NOUN
bionys-589	204	13	-	-	PUNCT
bionys-589	204	14	controlled	control	VERB
bionys-589	204	15	processes	process	NOUN
bionys-589	204	16	influence	influence	VERB
bionys-589	204	17	the	the	DET
bionys-589	204	18	mechanism	mechanism	NOUN
bionys-589	204	19	of	of	ADP
bionys-589	204	20	drug	drug	NOUN
bionys-589	204	21	release	release	NOUN
bionys-589	204	22	.	.	PUNCT
bionys-589	205	1	the	the	DET
bionys-589	205	2	results	result	NOUN
bionys-589	205	3	of	of	ADP
bionys-589	205	4	in	in	ADP
bionys-589	205	5	vitro	vitro	X
bionys-589	205	6	antiparkinson	antiparkinson	NOUN
bionys-589	205	7	activity	activity	NOUN
bionys-589	205	8	confirmed	confirm	VERB
bionys-589	205	9	that	that	SCONJ
bionys-589	205	10	the	the	DET
bionys-589	205	11	optimized	optimize	VERB
bionys-589	205	12	nanoparticle	nanoparticle	NOUN
bionys-589	205	13	has	have	VERB
bionys-589	205	14	significant	significant	ADJ
bionys-589	205	15	neuroprotective	neuroprotective	ADJ
bionys-589	205	16	effects	effect	NOUN
bionys-589	205	17	of	of	ADP
bionys-589	205	18	the	the	DET
bionys-589	205	19	drug	drug	NOUN
bionys-589	205	20	from	from	ADP
bionys-589	205	21	an	an	DET
bionys-589	205	22	increase	increase	NOUN
bionys-589	205	23	in	in	ADP
bionys-589	205	24	percentage	percentage	NOUN
bionys-589	205	25	viability	viability	NOUN
bionys-589	205	26	and	and	CCONJ
bionys-589	205	27	betterment	betterment	NOUN
bionys-589	205	28	of	of	ADP
bionys-589	205	29	cell	cell	NOUN
bionys-589	205	30	morphology	morphology	NOUN
bionys-589	205	31	.	.	PUNCT
bionys-589	206	1	hence	hence	ADV
bionys-589	206	2	,	,	PUNCT
bionys-589	206	3	a	a	DET
bionys-589	206	4	combination	combination	NOUN
bionys-589	206	5	of	of	ADP
bionys-589	206	6	curcumin	curcumin	NOUN
bionys-589	206	7	and	and	CCONJ
bionys-589	206	8	amantadine	amantadine	ADJ
bionys-589	206	9	nanoparticles	nanoparticle	NOUN
bionys-589	206	10	will	will	AUX
bionys-589	206	11	be	be	AUX
bionys-589	206	12	a	a	DET
bionys-589	206	13	better	well	ADJ
bionys-589	206	14	choice	choice	NOUN
bionys-589	206	15	for	for	ADP
bionys-589	206	16	neuroprotective	neuroprotective	ADJ
bionys-589	206	17	effects	effect	NOUN
bionys-589	206	18	.	.	PUNCT
bionys-589	207	1	acknowledgements	acknowledgement	NOUN
bionys-589	207	2	.	.	PUNCT
bionys-589	208	1	i	i	PRON
bionys-589	208	2	would	would	AUX
bionys-589	208	3	like	like	VERB
bionys-589	208	4	to	to	PART
bionys-589	208	5	thank	thank	VERB
bionys-589	208	6	the	the	DET
bionys-589	208	7	centre	centre	NOUN
bionys-589	208	8	for	for	ADP
bionys-589	208	9	food	food	NOUN
bionys-589	208	10	nanotechnology	nanotechnology	PROPN
bionys-589	208	11	,	,	PUNCT
bionys-589	208	12	karpagam	karpagam	PROPN
bionys-589	208	13	academy	academy	PROPN
bionys-589	208	14	of	of	ADP
bionys-589	208	15	higher	high	ADJ
bionys-589	208	16	education	education	NOUN
bionys-589	208	17	,	,	PUNCT
bionys-589	208	18	coimbatore	coimbatore	NOUN
bionys-589	208	19	for	for	ADP
bionys-589	208	20	helping	help	VERB
bionys-589	208	21	me	i	PRON
bionys-589	208	22	to	to	PART
bionys-589	208	23	perform	perform	VERB
bionys-589	208	24	particle	particle	NOUN
bionys-589	208	25	size	size	NOUN
bionys-589	208	26	analysis	analysis	NOUN
bionys-589	208	27	and	and	CCONJ
bionys-589	208	28	zeta	zeta	NOUN
bionys-589	208	29	potential	potential	ADJ
bionys-589	208	30	characterization	characterization	NOUN
bionys-589	208	31	.	.	PUNCT
bionys-589	209	1	references	reference	NOUN
bionys-589	209	2	alonso	alonso	PROPN
bionys-589	209	3	,	,	PUNCT
bionys-589	209	4	m.j	m.j	PROPN
bionys-589	209	5	.	.	PROPN
bionys-589	209	6	&	&	CCONJ
bionys-589	209	7	couvreur	couvreur	PROPN
bionys-589	209	8	,	,	PUNCT
bionys-589	209	9	p.	p.	NOUN
bionys-589	209	10	(	(	PUNCT
bionys-589	209	11	2012	2012	NUM
bionys-589	209	12	)	)	PUNCT
bionys-589	209	13	.	.	PUNCT
bionys-589	210	1	historical	historical	ADJ
bionys-589	210	2	view	view	NOUN
bionys-589	210	3	ta	ta	X
bionys-589	210	4	bl	bl	VERB
bionys-589	210	5	e	e	PROPN
bionys-589	210	6	4	4	NUM
bionys-589	210	7	.	.	PUNCT
bionys-589	211	1	p	p	X
bionys-589	211	2	er	er	INTJ
bionys-589	211	3	ce	ce	PROPN
bionys-589	211	4	nt	not	PART
bionys-589	211	5	ag	ag	PROPN
bionys-589	211	6	e	e	PROPN
bionys-589	211	7	vi	vi	PROPN
bionys-589	211	8	ab	ab	PROPN
bionys-589	211	9	ilit	ilit	NOUN
bionys-589	211	10	y	y	PROPN
bionys-589	211	11	of	of	ADP
bionys-589	211	12	c	c	PROPN
bionys-589	211	13	ur	ur	PROPN
bionys-589	211	14	cu	cu	PROPN
bionys-589	211	15	m	m	VERB
bionys-589	211	16	in	in	ADP
bionys-589	211	17	+	+	PROPN
bionys-589	211	18	a	a	DET
bionys-589	211	19	m	m	NOUN
bionys-589	211	20	an	an	DET
bionys-589	211	21	ta	ta	X
bionys-589	211	22	di	di	X
bionys-589	211	23	ne	ne	PROPN
bionys-589	211	24	n	n	PROPN
bionys-589	211	25	an	an	DET
bionys-589	211	26	op	op	NOUN
bionys-589	211	27	ar	ar	PROPN
bionys-589	211	28	tic	tic	PROPN
bionys-589	211	29	le	le	PROPN
bionys-589	211	30	s	s	PROPN
bionys-589	211	31	c	c	PROPN
bionys-589	211	32	el	el	PROPN
bionys-589	211	33	l	l	PROPN
bionys-589	211	34	l	l	NOUN
bionys-589	211	35	in	in	ADP
bionys-589	211	36	e	e	NOUN
bionys-589	211	37	sh	sh	PROPN
bionys-589	211	38	sy	sy	PROPN
bionys-589	211	39	5y	5y	NUM
bionys-589	211	40	sa	sa	X
bionys-589	211	41	m	m	VERB
bionys-589	211	42	pl	pl	X
bionys-589	211	43	e	e	X
bionys-589	211	44	c	c	NOUN
bionys-589	211	45	o	o	X
bionys-589	211	46	d	d	X
bionys-589	211	47	e	e	X
bionys-589	211	48	c	c	AUX
bionys-589	211	49	ur	ur	VERB
bionys-589	211	50	cu	cu	PROPN
bionys-589	211	51	m	m	VERB
bionys-589	211	52	in	in	ADP
bionys-589	211	53	+	+	CCONJ
bionys-589	211	54	a	a	DET
bionys-589	211	55	m	m	NOUN
bionys-589	211	56	an	an	PRON
bionys-589	211	57	ta	ta	X
bionys-589	211	58	di	di	X
bionys-589	211	59	ne	ne	NOUN
bionys-589	211	60	o	o	PROPN
bionys-589	212	1	d	d	X
bionys-589	212	2	1	1	NUM
bionys-589	212	3	o	o	NOUN
bionys-589	212	4	d	d	X
bionys-589	212	5	2	2	NUM
bionys-589	212	6	o	o	NOUN
bionys-589	212	7	d	d	X
bionys-589	212	8	3	3	X
bionys-589	212	9	pe	pe	PROPN
bionys-589	212	10	rc	rc	PROPN
bionys-589	212	11	en	en	X
bionys-589	212	12	ta	ta	PROPN
bionys-589	212	13	ge	ge	PROPN
bionys-589	212	14	v	v	PROPN
bionys-589	212	15	ia	ia	PROPN
bionys-589	212	16	bi	bi	PROPN
bionys-589	212	17	lit	light	VERB
bionys-589	212	18	y	y	PROPN
bionys-589	212	19	1	1	NUM
bionys-589	212	20	pe	pe	PROPN
bionys-589	212	21	rc	rc	PROPN
bionys-589	212	22	en	en	X
bionys-589	212	23	ta	ta	PROPN
bionys-589	212	24	ge	ge	PROPN
bionys-589	212	25	v	v	PROPN
bionys-589	212	26	ia	ia	PROPN
bionys-589	212	27	bi	bi	PROPN
bionys-589	212	28	lit	light	VERB
bionys-589	212	29	y	y	PROPN
bionys-589	212	30	2	2	NUM
bionys-589	212	31	pe	pe	PROPN
bionys-589	212	32	rc	rc	PROPN
bionys-589	212	33	en	en	X
bionys-589	212	34	ta	ta	PROPN
bionys-589	212	35	ge	ge	PROPN
bionys-589	212	36	v	v	PROPN
bionys-589	212	37	ia	ia	PROPN
bionys-589	212	38	bi	bi	PROPN
bionys-589	212	39	lit	light	VERB
bionys-589	212	40	y	y	PROPN
bionys-589	212	41	3	3	NUM
bionys-589	212	42	a	a	DET
bionys-589	212	43	ve	ve	NOUN
bionys-589	212	44	ra	ra	PROPN
bionys-589	212	45	ge	ge	PROPN
bionys-589	212	46	st	st	PROPN
bionys-589	213	1	d	d	PROPN
bionys-589	213	2	d	d	PROPN
bionys-589	213	3	ev	ev	PROPN
bionys-589	213	4	st	st	PROPN
bionys-589	213	5	d	d	PROPN
bionys-589	213	6	e	e	PROPN
bionys-589	213	7	rr	rr	NOUN
bionys-589	213	8	or	or	CCONJ
bionys-589	213	9	c	c	X
bionys-589	213	10	on	on	ADP
bionys-589	213	11	tr	tr	VERB
bionys-589	213	12	ol	ol	PROPN
bionys-589	213	13	0	0	NUM
bionys-589	213	14	.	.	PUNCT
bionys-589	214	1	87	87	NUM
bionys-589	214	2	48	48	NUM
bionys-589	214	3	0	0	NUM
bionys-589	214	4	.	.	PUNCT
bionys-589	215	1	88	88	NUM
bionys-589	215	2	17	17	NUM
bionys-589	215	3	0	0	NUM
bionys-589	215	4	.	.	PUNCT
bionys-589	216	1	86	86	NUM
bionys-589	216	2	09	09	NUM
bionys-589	216	3	10	10	NUM
bionys-589	216	4	0	0	NUM
bionys-589	216	5	10	10	NUM
bionys-589	216	6	0	0	NUM
bionys-589	216	7	10	10	NUM
bionys-589	216	8	0	0	NUM
bionys-589	216	9	10	10	NUM
bionys-589	216	10	0	0	NUM
bionys-589	216	11	0	0	NUM
bionys-589	216	12	0	0	NUM
bionys-589	216	13	r	r	NOUN
bionys-589	216	14	ot	ot	NOUN
bionys-589	216	15	en	en	X
bionys-589	216	16	on	on	ADP
bionys-589	216	17	e	e	PROPN
bionys-589	216	18	0	0	NUM
bionys-589	216	19	.	.	PUNCT
bionys-589	217	1	42	42	NUM
bionys-589	217	2	08	08	NUM
bionys-589	217	3	0	0	NUM
bionys-589	217	4	.	.	PUNCT
bionys-589	218	1	41	41	NUM
bionys-589	218	2	31	31	NUM
bionys-589	218	3	0	0	NUM
bionys-589	218	4	.	.	PUNCT
bionys-589	219	1	41	41	NUM
bionys-589	219	2	98	98	NUM
bionys-589	219	3	48	48	NUM
bionys-589	219	4	.1	.1	NUM
bionys-589	219	5	02	02	NUM
bionys-589	219	6	4	4	NUM
bionys-589	219	7	46	46	NUM
bionys-589	219	8	.8	.8	NUM
bionys-589	219	9	52	52	NUM
bionys-589	219	10	7	7	NUM
bionys-589	219	11	48	48	NUM
bionys-589	219	12	.7	.7	NUM
bionys-589	219	13	62	62	NUM
bionys-589	219	14	9	9	NUM
bionys-589	219	15	47	47	NUM
bionys-589	219	16	.9	.9	NUM
bionys-589	219	17	06	06	NUM
bionys-589	219	18	0	0	NUM
bionys-589	219	19	.	.	PUNCT
bionys-589	220	1	97	97	NUM
bionys-589	220	2	01	01	NUM
bionys-589	220	3	5	5	NUM
bionys-589	220	4	0	0	NUM
bionys-589	220	5	.	.	PUNCT
bionys-589	221	1	32	32	NUM
bionys-589	221	2	33	33	NUM
bionys-589	221	3	8	8	NUM
bionys-589	221	4	1	1	NUM
bionys-589	221	5	.	.	ADP
bionys-589	221	6	5	5	NUM
bionys-589	221	7	0	0	NUM
bionys-589	221	8	.	.	PUNCT
bionys-589	222	1	46	46	NUM
bionys-589	222	2	43	43	NUM
bionys-589	222	3	0	0	NUM
bionys-589	222	4	.	.	PUNCT
bionys-589	223	1	47	47	NUM
bionys-589	223	2	29	29	NUM
bionys-589	223	3	0	0	NUM
bionys-589	223	4	.	.	PUNCT
bionys-589	224	1	47	47	NUM
bionys-589	224	2	37	37	NUM
bionys-589	224	3	53	53	NUM
bionys-589	224	4	.0	.0	NUM
bionys-589	224	5	75	75	NUM
bionys-589	224	6	53	53	NUM
bionys-589	224	7	.6	.6	NUM
bionys-589	224	8	35	35	NUM
bionys-589	224	9	55	55	NUM
bionys-589	224	10	.0	.0	NUM
bionys-589	224	11	23	23	NUM
bionys-589	224	12	8	8	NUM
bionys-589	224	13	53	53	NUM
bionys-589	224	14	.9	.9	NUM
bionys-589	224	15	11	11	NUM
bionys-589	224	16	3	3	NUM
bionys-589	224	17	1	1	NUM
bionys-589	224	18	.	.	PUNCT
bionys-589	224	19	00	00	NUM
bionys-589	225	1	33	33	NUM
bionys-589	225	2	5	5	NUM
bionys-589	225	3	0	0	NUM
bionys-589	225	4	.	.	PUNCT
bionys-589	226	1	33	33	NUM
bionys-589	226	2	44	44	NUM
bionys-589	226	3	5	5	NUM
bionys-589	226	4	3	3	NUM
bionys-589	226	5	.	.	NOUN
bionys-589	226	6	1	1	NUM
bionys-589	226	7	0	0	NUM
bionys-589	226	8	.	.	PUNCT
bionys-589	227	1	55	55	NUM
bionys-589	227	2	14	14	NUM
bionys-589	227	3	0	0	NUM
bionys-589	227	4	.	.	PUNCT
bionys-589	228	1	54	54	NUM
bionys-589	228	2	13	13	NUM
bionys-589	228	3	0	0	NUM
bionys-589	228	4	.	.	PUNCT
bionys-589	229	1	55	55	NUM
bionys-589	229	2	25	25	NUM
bionys-589	229	3	63	63	NUM
bionys-589	229	4	.0	.0	NUM
bionys-589	229	5	31	31	NUM
bionys-589	229	6	6	6	NUM
bionys-589	229	7	61	61	NUM
bionys-589	229	8	.3	.3	NUM
bionys-589	229	9	92	92	NUM
bionys-589	229	10	8	8	NUM
bionys-589	229	11	64	64	NUM
bionys-589	229	12	.1	.1	NUM
bionys-589	229	13	77	77	NUM
bionys-589	229	14	62	62	NUM
bionys-589	229	15	.8	.8	NUM
bionys-589	229	16	67	67	NUM
bionys-589	229	17	1	1	NUM
bionys-589	229	18	1	1	NUM
bionys-589	229	19	.	.	X
bionys-589	229	20	39	39	NUM
bionys-589	229	21	93	93	NUM
bionys-589	229	22	9	9	NUM
bionys-589	229	23	0	0	NUM
bionys-589	229	24	.	.	PUNCT
bionys-589	230	1	46	46	NUM
bionys-589	230	2	64	64	NUM
bionys-589	230	3	6	6	NUM
bionys-589	230	4	6	6	NUM
bionys-589	230	5	.	.	PUNCT
bionys-589	231	1	25	25	NUM
bionys-589	231	2	0	0	NUM
bionys-589	231	3	.	.	PUNCT
bionys-589	232	1	59	59	NUM
bionys-589	232	2	56	56	NUM
bionys-589	232	3	0	0	NUM
bionys-589	232	4	.	.	PUNCT
bionys-589	233	1	60	60	NUM
bionys-589	233	2	68	68	NUM
bionys-589	233	3	0	0	NUM
bionys-589	233	4	.	.	PUNCT
bionys-589	234	1	60	60	NUM
bionys-589	234	2	1	1	NUM
bionys-589	234	3	68	68	NUM
bionys-589	234	4	.0	.0	NUM
bionys-589	234	5	84	84	NUM
bionys-589	234	6	1	1	NUM
bionys-589	234	7	68	68	NUM
bionys-589	234	8	.8	.8	NUM
bionys-589	234	9	21	21	NUM
bionys-589	234	10	6	6	NUM
bionys-589	234	11	69	69	NUM
bionys-589	234	12	.8	.8	NUM
bionys-589	234	13	10	10	NUM
bionys-589	234	14	7	7	NUM
bionys-589	234	15	68	68	NUM
bionys-589	234	16	.9	.9	NUM
bionys-589	234	17	05	05	NUM
bionys-589	234	18	5	5	NUM
bionys-589	234	19	0	0	NUM
bionys-589	234	20	.	.	PUNCT
bionys-589	235	1	86	86	NUM
bionys-589	235	2	63	63	NUM
bionys-589	235	3	2	2	NUM
bionys-589	235	4	0	0	NUM
bionys-589	235	5	.	.	PUNCT
bionys-589	236	1	28	28	NUM
bionys-589	236	2	87	87	NUM
bionys-589	236	3	7	7	NUM
bionys-589	236	4	12	12	NUM
bionys-589	236	5	.5	.5	NUM
bionys-589	236	6	0	0	NUM
bionys-589	236	7	.	.	PUNCT
bionys-589	237	1	65	65	NUM
bionys-589	237	2	6	6	NUM
bionys-589	237	3	0	0	NUM
bionys-589	237	4	.	.	PUNCT
bionys-589	238	1	66	66	NUM
bionys-589	238	2	39	39	NUM
bionys-589	238	3	0	0	NUM
bionys-589	238	4	.	.	PUNCT
bionys-589	239	1	65	65	NUM
bionys-589	239	2	74	74	NUM
bionys-589	239	3	74	74	NUM
bionys-589	239	4	.9	.9	NUM
bionys-589	239	5	88	88	NUM
bionys-589	239	6	6	6	NUM
bionys-589	239	7	75	75	NUM
bionys-589	239	8	.2	.2	NUM
bionys-589	239	9	97	97	NUM
bionys-589	239	10	7	7	NUM
bionys-589	239	11	76	76	NUM
bionys-589	239	12	.3	.3	NUM
bionys-589	239	13	61	61	NUM
bionys-589	239	14	9	9	NUM
bionys-589	239	15	75	75	NUM
bionys-589	239	16	.5	.5	NUM
bionys-589	239	17	49	49	NUM
bionys-589	239	18	4	4	NUM
bionys-589	239	19	0	0	NUM
bionys-589	239	20	.	.	PUNCT
bionys-589	240	1	72	72	NUM
bionys-589	240	2	04	04	NUM
bionys-589	240	3	5	5	NUM
bionys-589	240	4	0	0	NUM
bionys-589	240	5	.	.	NUM
bionys-589	241	1	24	24	NUM
bionys-589	241	2	01	01	NUM
bionys-589	241	3	5	5	NUM
bionys-589	241	4	25	25	NUM
bionys-589	241	5	0	0	NUM
bionys-589	241	6	.	.	PUNCT
bionys-589	242	1	73	73	NUM
bionys-589	242	2	24	24	NUM
bionys-589	242	3	0	0	NUM
bionys-589	242	4	.	.	PUNCT
bionys-589	242	5	72	72	NUM
bionys-589	242	6	29	29	NUM
bionys-589	242	7	0	0	NUM
bionys-589	242	8	.	.	PUNCT
bionys-589	243	1	73	73	NUM
bionys-589	243	2	51	51	NUM
bionys-589	243	3	83	83	NUM
bionys-589	243	4	.7	.7	NUM
bionys-589	243	5	22	22	NUM
bionys-589	243	6	81	81	NUM
bionys-589	243	7	.9	.9	NUM
bionys-589	243	8	89	89	NUM
bionys-589	243	9	3	3	NUM
bionys-589	243	10	85	85	NUM
bionys-589	243	11	.3	.3	NUM
bionys-589	243	12	87	87	NUM
bionys-589	243	13	4	4	NUM
bionys-589	243	14	83	83	NUM
bionys-589	243	15	.6	.6	NUM
bionys-589	243	16	99	99	NUM
bionys-589	243	17	6	6	NUM
bionys-589	243	18	1	1	NUM
bionys-589	243	19	.	.	PUNCT
bionys-589	243	20	69	69	NUM
bionys-589	243	21	91	91	NUM
bionys-589	243	22	3	3	NUM
bionys-589	243	23	0	0	NUM
bionys-589	243	24	.	.	PUNCT
bionys-589	244	1	56	56	NUM
bionys-589	244	2	63	63	NUM
bionys-589	244	3	8	8	NUM
bionys-589	244	4	275	275	NUM
bionys-589	244	5	biologica	biologica	NOUN
bionys-589	244	6	nyssana	nyssana	PROPN
bionys-589	244	7	●	●	PUNCT
bionys-589	244	8	16	16	NUM
bionys-589	244	9	(	(	PUNCT
bionys-589	244	10	1	1	NUM
bionys-589	244	11	)	)	PUNCT
bionys-589	244	12	june	june	PROPN
bionys-589	244	13	2025	2025	NUM
bionys-589	244	14	:	:	PUNCT
bionys-589	244	15	267	267	NUM
bionys-589	244	16	-	-	SYM
bionys-589	244	17	276	276	NUM
bionys-589	244	18	alex	alex	PROPN
bionys-589	244	19	et	et	PROPN
bionys-589	244	20	al	al	PROPN
bionys-589	244	21	.	.	PUNCT
bionys-589	245	1	●	●	PUNCT
bionys-589	245	2	formulation	formulation	NOUN
bionys-589	245	3	and	and	CCONJ
bionys-589	245	4	characterization	characterization	NOUN
bionys-589	245	5	of	of	ADP
bionys-589	245	6	nanoparticles	nanoparticle	NOUN
bionys-589	245	7	loaded	load	VERB
bionys-589	245	8	with	with	ADP
bionys-589	245	9	curcumin	curcumin	NOUN
bionys-589	245	10	and	and	CCONJ
bionys-589	245	11	amantadine	amantadine	NOUN
bionys-589	245	12	as	as	ADP
bionys-589	245	13	a	a	DET
bionys-589	245	14	promising	promising	ADJ
bionys-589	245	15	neuroprotective	neuroprotective	ADJ
bionys-589	245	16	agent	agent	NOUN
bionys-589	245	17	of	of	ADP
bionys-589	245	18	the	the	DET
bionys-589	245	19	design	design	NOUN
bionys-589	245	20	and	and	CCONJ
bionys-589	245	21	development	development	NOUN
bionys-589	245	22	of	of	ADP
bionys-589	245	23	nanocarriers	nanocarrier	NOUN
bionys-589	245	24	for	for	ADP
bionys-589	245	25	overcoming	overcome	VERB
bionys-589	245	26	biological	biological	ADJ
bionys-589	245	27	barriers	barrier	NOUN
bionys-589	245	28	.	.	PUNCT
bionys-589	246	1	in	in	ADP
bionys-589	246	2	:	:	PUNCT
bionys-589	246	3	nanostructured	nanostructure	VERB
bionys-589	246	4	biomaterials	biomaterial	NOUN
bionys-589	246	5	for	for	ADP
bionys-589	246	6	overcoming	overcome	VERB
bionys-589	246	7	biological	biological	ADJ
bionys-589	246	8	barriers	barrier	NOUN
bionys-589	246	9	(	(	PUNCT
bionys-589	246	10	pp	pp	ADJ
bionys-589	246	11	.	.	PUNCT
bionys-589	246	12	3	3	NUM
bionys-589	246	13	-	-	SYM
bionys-589	246	14	36	36	NUM
bionys-589	246	15	)	)	PUNCT
bionys-589	246	16	.	.	PUNCT
bionys-589	247	1	uk	uk	PROPN
bionys-589	247	2	,	,	PUNCT
bionys-589	247	3	cambridge	cambridge	PROPN
bionys-589	247	4	:	:	PUNCT
bionys-589	247	5	the	the	DET
bionys-589	247	6	royal	royal	ADJ
bionys-589	247	7	society	society	NOUN
bionys-589	247	8	of	of	ADP
bionys-589	247	9	chemistry	chemistry	NOUN
bionys-589	247	10	.	.	PUNCT
bionys-589	248	1	cheng	cheng	PROPN
bionys-589	248	2	,	,	PUNCT
bionys-589	248	3	k.k	k.k	PROPN
bionys-589	248	4	.	.	PROPN
bionys-589	248	5	,	,	PUNCT
bionys-589	248	6	yeung	yeung	PROPN
bionys-589	248	7	,	,	PUNCT
bionys-589	248	8	c.f	c.f	PROPN
bionys-589	248	9	.	.	PROPN
bionys-589	248	10	,	,	PUNCT
bionys-589	248	11	ho	ho	PROPN
bionys-589	248	12	,	,	PUNCT
bionys-589	248	13	s.w	s.w	PROPN
bionys-589	248	14	.	.	PROPN
bionys-589	248	15	,	,	PUNCT
bionys-589	248	16	chow	chow	PROPN
bionys-589	248	17	,	,	PUNCT
bionys-589	248	18	s.f	s.f	PROPN
bionys-589	248	19	.	.	PROPN
bionys-589	248	20	,	,	PUNCT
bionys-589	248	21	chow	chow	PROPN
bionys-589	248	22	,	,	PUNCT
bionys-589	248	23	a.h	a.h	PROPN
bionys-589	248	24	.	.	PROPN
bionys-589	248	25	,	,	PUNCT
bionys-589	248	26	&	&	CCONJ
bionys-589	248	27	baum	baum	PROPN
bionys-589	248	28	,	,	PUNCT
bionys-589	248	29	l.	l.	PROPN
bionys-589	248	30	(	(	PUNCT
bionys-589	248	31	2013	2013	NUM
bionys-589	248	32	)	)	PUNCT
bionys-589	248	33	.	.	PUNCT
bionys-589	249	1	highly	highly	ADV
bionys-589	249	2	stabilized	stabilize	VERB
bionys-589	249	3	curcumin	curcumin	NOUN
bionys-589	249	4	nanoparticles	nanoparticle	NOUN
bionys-589	249	5	tested	test	VERB
bionys-589	249	6	in	in	ADP
bionys-589	249	7	an	an	DET
bionys-589	249	8	in	in	ADP
bionys-589	249	9	vitro	vitro	X
bionys-589	249	10	blood	blood	NOUN
bionys-589	249	11	–	–	PUNCT
bionys-589	249	12	brain	brain	NOUN
bionys-589	249	13	barrier	barrier	NOUN
bionys-589	249	14	model	model	NOUN
bionys-589	249	15	and	and	CCONJ
bionys-589	249	16	in	in	ADP
bionys-589	249	17	alzheimer	alzheimer	PROPN
bionys-589	249	18	’s	’s	PART
bionys-589	249	19	disease	disease	NOUN
bionys-589	249	20	tg2576	tg2576	PROPN
bionys-589	249	21	mice	mouse	NOUN
bionys-589	249	22	.	.	PUNCT
bionys-589	250	1	the	the	DET
bionys-589	250	2	aaps	aaps	PROPN
bionys-589	250	3	journal	journal	NOUN
bionys-589	250	4	,	,	PUNCT
bionys-589	250	5	15	15	NUM
bionys-589	250	6	,	,	PUNCT
bionys-589	250	7	324	324	NUM
bionys-589	250	8	-	-	SYM
bionys-589	250	9	336	336	NUM
bionys-589	250	10	.	.	PUNCT
bionys-589	251	1	doi	doi	NOUN
bionys-589	251	2	:	:	PUNCT
bionys-589	251	3	10.1208	10.1208	NUM
bionys-589	251	4	/	/	SYM
bionys-589	251	5	s12248	s12248	PROPN
bionys-589	251	6	-	-	PUNCT
bionys-589	251	7	012	012	NUM
bionys-589	251	8	-	-	PUNCT
bionys-589	251	9	9444	9444	NUM
bionys-589	251	10	-	-	SYM
bionys-589	251	11	4	4	NUM
bionys-589	251	12	.	.	PUNCT
bionys-589	252	1	dorsey	dorsey	PROPN
bionys-589	252	2	,	,	PUNCT
bionys-589	252	3	e.r	e.r	PROPN
bionys-589	252	4	.	.	PROPN
bionys-589	252	5	&	&	CCONJ
bionys-589	252	6	bloem	bloem	PROPN
bionys-589	252	7	,	,	PUNCT
bionys-589	252	8	b.r	b.r	PROPN
bionys-589	252	9	.	.	PROPN
bionys-589	252	10	(	(	PUNCT
bionys-589	252	11	2018	2018	NUM
bionys-589	252	12	)	)	PUNCT
bionys-589	252	13	.	.	PUNCT
bionys-589	253	1	the	the	DET
bionys-589	253	2	parkinson	parkinson	NOUN
bionys-589	253	3	pandemic	pandemic	NOUN
bionys-589	253	4	a	a	DET
bionys-589	253	5	call	call	NOUN
bionys-589	253	6	to	to	ADP
bionys-589	253	7	action	action	NOUN
bionys-589	253	8	.	.	PUNCT
bionys-589	254	1	jama	jama	PROPN
bionys-589	254	2	neurology	neurology	NOUN
bionys-589	254	3	,	,	PUNCT
bionys-589	254	4	75(1	75(1	NOUN
bionys-589	254	5	)	)	PUNCT
bionys-589	254	6	,	,	PUNCT
bionys-589	254	7	9	9	NUM
bionys-589	254	8	-	-	SYM
bionys-589	254	9	10	10	NUM
bionys-589	254	10	.	.	PUNCT
bionys-589	255	1	doi	doi	NOUN
bionys-589	255	2	:	:	PUNCT
bionys-589	255	3	10.1001	10.1001	NUM
bionys-589	255	4	/	/	SYM
bionys-589	255	5	jamaneurol.2017.3299	jamaneurol.2017.3299	PROPN
bionys-589	255	6	.	.	PUNCT
bionys-589	256	1	espay	espay	PROPN
bionys-589	256	2	,	,	PUNCT
bionys-589	256	3	a.j	a.j	PROPN
bionys-589	256	4	.	.	PROPN
bionys-589	256	5	,	,	PUNCT
bionys-589	256	6	ostrem	ostrem	PROPN
bionys-589	256	7	,	,	PUNCT
bionys-589	256	8	j.l	j.l	PROPN
bionys-589	256	9	.	.	PROPN
bionys-589	256	10	,	,	PUNCT
bionys-589	256	11	formella	formella	PROPN
bionys-589	256	12	,	,	PUNCT
bionys-589	256	13	a.e	a.e	PROPN
bionys-589	256	14	.	.	PROPN
bionys-589	256	15	,	,	PUNCT
bionys-589	256	16	&	&	CCONJ
bionys-589	256	17	tanner	tanner	PROPN
bionys-589	256	18	,	,	PUNCT
bionys-589	256	19	c.m	c.m	PROPN
bionys-589	256	20	.	.	PROPN
bionys-589	256	21	(	(	PUNCT
bionys-589	256	22	2024	2024	NUM
bionys-589	256	23	)	)	PUNCT
bionys-589	256	24	.	.	PUNCT
bionys-589	257	1	extended	extend	VERB
bionys-589	257	2	-	-	PUNCT
bionys-589	257	3	release	release	NOUN
bionys-589	257	4	amantadine	amantadine	NOUN
bionys-589	257	5	for	for	ADP
bionys-589	257	6	off	off	ADV
bionys-589	257	7	-	-	PUNCT
bionys-589	257	8	related	relate	VERB
bionys-589	257	9	dystonia	dystonia	NOUN
bionys-589	257	10	in	in	ADP
bionys-589	257	11	parkinson	parkinson	NOUN
bionys-589	257	12	's	's	PART
bionys-589	257	13	disease	disease	NOUN
bionys-589	257	14	.	.	PUNCT
bionys-589	258	1	parkinsonism	parkinsonism	PROPN
bionys-589	258	2	&	&	CCONJ
bionys-589	258	3	related	related	ADJ
bionys-589	258	4	disorders	disorder	NOUN
bionys-589	258	5	,	,	PUNCT
bionys-589	258	6	122	122	NUM
bionys-589	258	7	,	,	PUNCT
bionys-589	258	8	106088	106088	NUM
bionys-589	258	9	.	.	PUNCT
bionys-589	259	1	fig	fig	NOUN
bionys-589	259	2	.	.	PUNCT
bionys-589	260	1	5	5	NUM
bionys-589	260	2	.	.	X
bionys-589	260	3	percentage	percentage	NOUN
bionys-589	260	4	viability	viability	NOUN
bionys-589	260	5	of	of	ADP
bionys-589	260	6	cells	cell	NOUN
bionys-589	260	7	fig	fig	NOUN
bionys-589	260	8	.	.	PUNCT
bionys-589	261	1	6	6	X
bionys-589	261	2	.	.	X
bionys-589	261	3	microscopic	microscopic	ADJ
bionys-589	261	4	images	image	NOUN
bionys-589	261	5	of	of	ADP
bionys-589	261	6	control	control	NOUN
bionys-589	261	7	(	(	PUNCT
bionys-589	261	8	6a	6a	NOUN
bionys-589	261	9	)	)	PUNCT
bionys-589	261	10	,	,	PUNCT
bionys-589	261	11	rotenone	rotenone	NOUN
bionys-589	261	12	(	(	PUNCT
bionys-589	261	13	6b	6b	NOUN
bionys-589	261	14	)	)	PUNCT
bionys-589	261	15	,	,	PUNCT
bionys-589	261	16	varied	varied	ADJ
bionys-589	261	17	concentrations	concentration	NOUN
bionys-589	261	18	of	of	ADP
bionys-589	261	19	nanoparticle	nanoparticle	NOUN
bionys-589	261	20	1.5	1.5	NUM
bionys-589	261	21	µg	µg	NOUN
bionys-589	261	22	/	/	SYM
bionys-589	261	23	ml	ml	PROPN
bionys-589	261	24	(	(	PUNCT
bionys-589	261	25	6c	6c	NOUN
bionys-589	261	26	)	)	PUNCT
bionys-589	261	27	,	,	PUNCT
bionys-589	261	28	3.1	3.1	NUM
bionys-589	261	29	µg	µg	NOUN
bionys-589	261	30	/	/	SYM
bionys-589	261	31	ml	ml	NOUN
bionys-589	261	32	(	(	PUNCT
bionys-589	261	33	6d	6d	NUM
bionys-589	261	34	)	)	PUNCT
bionys-589	261	35	,	,	PUNCT
bionys-589	261	36	6.25	6.25	NUM
bionys-589	261	37	µg	µg	NOUN
bionys-589	261	38	/	/	SYM
bionys-589	261	39	ml	ml	PROPN
bionys-589	261	40	(	(	PUNCT
bionys-589	261	41	6e	6e	NOUN
bionys-589	261	42	)	)	PUNCT
bionys-589	261	43	,	,	PUNCT
bionys-589	261	44	and	and	CCONJ
bionys-589	261	45	12.5	12.5	NUM
bionys-589	261	46	µg	µg	NOUN
bionys-589	261	47	/	/	SYM
bionys-589	261	48	ml	ml	NOUN
bionys-589	261	49	(	(	PUNCT
bionys-589	261	50	6e	6e	NOUN
bionys-589	261	51	)	)	PUNCT
bionys-589	261	52	276	276	NUM
bionys-589	261	53	biologica	biologica	PROPN
bionys-589	261	54	nyssana	nyssana	PROPN
bionys-589	262	1	●	●	PUNCT
bionys-589	262	2	16	16	NUM
bionys-589	262	3	(	(	PUNCT
bionys-589	262	4	1	1	NUM
bionys-589	262	5	)	)	PUNCT
bionys-589	262	6	june	june	PROPN
bionys-589	262	7	2025	2025	NUM
bionys-589	262	8	:	:	PUNCT
bionys-589	262	9	alex	alex	PROPN
bionys-589	262	10	et	et	PROPN
bionys-589	262	11	al	al	PROPN
bionys-589	262	12	.	.	PUNCT
bionys-589	262	13	●	●	PUNCT
bionys-589	262	14	formulation	formulation	NOUN
bionys-589	262	15	and	and	CCONJ
bionys-589	262	16	characterization	characterization	NOUN
bionys-589	262	17	of	of	ADP
bionys-589	262	18	nanoparticles	nanoparticle	NOUN
bionys-589	262	19	loaded	load	VERB
bionys-589	262	20	with	with	ADP
bionys-589	262	21	curcumin	curcumin	NOUN
bionys-589	262	22	and	and	CCONJ
bionys-589	262	23	amantadine	amantadine	NOUN
bionys-589	262	24	as	as	ADP
bionys-589	262	25	a	a	DET
bionys-589	262	26	promising	promising	ADJ
bionys-589	262	27	neuroprotective	neuroprotective	ADJ
bionys-589	262	28	agent	agent	NOUN
bionys-589	262	29	https://doi.org/10.1016/j.parkreldis.2024.106088	https://doi.org/10.1016/j.parkreldis.2024.106088	PROPN
bionys-589	262	30	fink	fink	PROPN
bionys-589	262	31	,	,	PUNCT
bionys-589	262	32	k.	k.	PROPN
bionys-589	262	33	,	,	PUNCT
bionys-589	262	34	nitsche	nitsche	PROPN
bionys-589	262	35	,	,	PUNCT
bionys-589	262	36	a.	a.	PROPN
bionys-589	262	37	,	,	PUNCT
bionys-589	262	38	neumann	neumann	PROPN
bionys-589	262	39	,	,	PUNCT
bionys-589	262	40	m.	m.	NOUN
bionys-589	262	41	,	,	PUNCT
bionys-589	262	42	grossegesse	grossegesse	NOUN
bionys-589	262	43	,	,	PUNCT
bionys-589	262	44	m.	m.	NOUN
bionys-589	262	45	,	,	PUNCT
bionys-589	262	46	eisele	eisele	PROPN
bionys-589	262	47	,	,	PUNCT
bionys-589	262	48	k.h	k.h	PROPN
bionys-589	262	49	.	.	PROPN
bionys-589	262	50	,	,	PUNCT
bionys-589	262	51	&	&	CCONJ
bionys-589	262	52	danysz	danysz	PROPN
bionys-589	262	53	,	,	PUNCT
bionys-589	262	54	w.	w.	NOUN
bionys-589	262	55	(	(	PUNCT
bionys-589	262	56	2021	2021	NUM
bionys-589	262	57	)	)	PUNCT
bionys-589	262	58	.	.	PUNCT
bionys-589	263	1	amantadine	amantadine	PROPN
bionys-589	263	2	inhibits	inhibit	VERB
bionys-589	263	3	sars	sar	NOUN
bionys-589	263	4	-	-	PUNCT
bionys-589	263	5	cov-2	cov-2	NOUN
bionys-589	263	6	in	in	ADP
bionys-589	263	7	vitro	vitro	X
bionys-589	263	8	.	.	PUNCT
bionys-589	264	1	viruses	virus	NOUN
bionys-589	264	2	,	,	PUNCT
bionys-589	264	3	13(4	13(4	NOUN
bionys-589	264	4	)	)	PUNCT
bionys-589	264	5	,	,	PUNCT
bionys-589	264	6	539	539	NUM
bionys-589	264	7	.	.	PUNCT
bionys-589	265	1	kim	kim	PROPN
bionys-589	265	2	,	,	PUNCT
bionys-589	265	3	t.h	t.h	PROPN
bionys-589	265	4	.	.	PROPN
bionys-589	265	5	,	,	PUNCT
bionys-589	265	6	jiang	jiang	PROPN
bionys-589	265	7	,	,	PUNCT
bionys-589	265	8	h.h	h.h	PROPN
bionys-589	265	9	.	.	PROPN
bionys-589	265	10	,	,	PUNCT
bionys-589	265	11	youn	youn	PROPN
bionys-589	265	12	,	,	PUNCT
bionys-589	265	13	y.s	y.s	PROPN
bionys-589	265	14	.	.	PROPN
bionys-589	265	15	,	,	PUNCT
bionys-589	265	16	park	park	PROPN
bionys-589	265	17	,	,	PUNCT
bionys-589	265	18	c.w	c.w	PROPN
bionys-589	265	19	.	.	PROPN
bionys-589	265	20	,	,	PUNCT
bionys-589	265	21	tak	tak	NOUN
bionys-589	265	22	,	,	PUNCT
bionys-589	265	23	k.k	k.k	PROPN
bionys-589	265	24	.	.	PROPN
bionys-589	265	25	,	,	PUNCT
bionys-589	265	26	lee	lee	PROPN
bionys-589	265	27	,	,	PUNCT
bionys-589	265	28	s.	s.	PROPN
bionys-589	265	29	,	,	PUNCT
bionys-589	265	30	kim	kim	PROPN
bionys-589	265	31	,	,	PUNCT
bionys-589	265	32	h.	h.	PROPN
bionys-589	265	33	,	,	PUNCT
bionys-589	265	34	jon	jon	PROPN
bionys-589	265	35	,	,	PUNCT
bionys-589	265	36	s.	s.	PROPN
bionys-589	265	37	,	,	PUNCT
bionys-589	265	38	chen	chen	PROPN
bionys-589	265	39	,	,	PUNCT
bionys-589	265	40	x.	x.	PROPN
bionys-589	265	41	,	,	PUNCT
bionys-589	265	42	&	&	CCONJ
bionys-589	265	43	lee	lee	PROPN
bionys-589	265	44	,	,	PUNCT
bionys-589	265	45	k.c	k.c	PROPN
bionys-589	265	46	.	.	PROPN
bionys-589	265	47	(	(	PUNCT
bionys-589	265	48	2011	2011	NUM
bionys-589	265	49	)	)	PUNCT
bionys-589	265	50	.	.	PUNCT
bionys-589	266	1	preparation	preparation	NOUN
bionys-589	266	2	and	and	CCONJ
bionys-589	266	3	characterization	characterization	NOUN
bionys-589	266	4	of	of	ADP
bionys-589	266	5	water	water	NOUN
bionys-589	266	6	-	-	PUNCT
bionys-589	266	7	soluble	soluble	ADJ
bionys-589	266	8	albumin	albumin	NOUN
bionys-589	266	9	-	-	PUNCT
bionys-589	266	10	bound	bind	VERB
bionys-589	266	11	curcumin	curcumin	NOUN
bionys-589	266	12	nanoparticles	nanoparticle	NOUN
bionys-589	266	13	with	with	ADP
bionys-589	266	14	improved	improved	ADJ
bionys-589	266	15	antitumor	antitumor	NOUN
bionys-589	266	16	activity	activity	NOUN
bionys-589	266	17	.	.	PUNCT
bionys-589	267	1	international	international	ADJ
bionys-589	267	2	journal	journal	PROPN
bionys-589	267	3	of	of	ADP
bionys-589	267	4	pharmaceutics	pharmaceutic	NOUN
bionys-589	267	5	,	,	PUNCT
bionys-589	267	6	403(1	403(1	NUM
bionys-589	267	7	-	-	SYM
bionys-589	267	8	2	2	NUM
bionys-589	267	9	)	)	PUNCT
bionys-589	267	10	,	,	PUNCT
bionys-589	267	11	285	285	NUM
bionys-589	267	12	-	-	SYM
bionys-589	267	13	291	291	NUM
bionys-589	267	14	.	.	PUNCT
bionys-589	268	1	doi	doi	NOUN
bionys-589	268	2	:	:	PUNCT
bionys-589	268	3	10.1016	10.1016	NUM
bionys-589	268	4	/	/	SYM
bionys-589	268	5	j.ijpharm.2010.10.041	j.ijpharm.2010.10.041	PROPN
bionys-589	268	6	.	.	PUNCT
bionys-589	269	1	gayathri	gayathri	PROPN
bionys-589	269	2	,	,	PUNCT
bionys-589	269	3	k.	k.	PROPN
bionys-589	269	4	,	,	PUNCT
bionys-589	269	5	bhaskaran	bhaskaran	NOUN
bionys-589	269	6	,	,	PUNCT
bionys-589	269	7	m.	m.	NOUN
bionys-589	269	8	,	,	PUNCT
bionys-589	269	9	selvam	selvam	PROPN
bionys-589	269	10	,	,	PUNCT
bionys-589	269	11	c.	c.	PROPN
bionys-589	269	12	,	,	PUNCT
bionys-589	269	13	&	&	CCONJ
bionys-589	269	14	thilagavathi	thilagavathi	PROPN
bionys-589	269	15	,	,	PUNCT
bionys-589	269	16	r.	r.	PROPN
bionys-589	269	17	(	(	PUNCT
bionys-589	269	18	2023	2023	NUM
bionys-589	269	19	)	)	PUNCT
bionys-589	269	20	.	.	PUNCT
bionys-589	270	1	nano	nano	NOUN
bionys-589	270	2	formulation	formulation	NOUN
bionys-589	270	3	approaches	approach	NOUN
bionys-589	270	4	for	for	ADP
bionys-589	270	5	curcumin	curcumin	NOUN
bionys-589	270	6	delivery	delivery	NOUN
bionys-589	270	7	-	-	PUNCT
bionys-589	270	8	a	a	DET
bionys-589	270	9	review	review	NOUN
bionys-589	270	10	.	.	PUNCT
bionys-589	271	1	journal	journal	PROPN
bionys-589	271	2	of	of	ADP
bionys-589	271	3	drug	drug	NOUN
bionys-589	271	4	delivery	delivery	NOUN
bionys-589	271	5	science	science	NOUN
bionys-589	271	6	and	and	CCONJ
bionys-589	271	7	technology	technology	NOUN
bionys-589	271	8	,	,	PUNCT
bionys-589	271	9	82	82	NUM
bionys-589	271	10	,	,	PUNCT
bionys-589	271	11	104326	104326	NUM
bionys-589	271	12	.	.	PUNCT
bionys-589	272	1	https	https	NOUN
bionys-589	272	2	:	:	PUNCT
bionys-589	273	1	//doi.org/10.1016	//doi.org/10.1016	PROPN
bionys-589	273	2	/	/	SYM
bionys-589	273	3	j.jddst.2023.104326	j.jddst.2023.104326	PROPN
bionys-589	273	4	.	.	PUNCT
bionys-589	274	1	maksymiuk	maksymiuk	PROPN
bionys-589	274	2	,	,	PUNCT
bionys-589	274	3	a.w	a.w	PROPN
bionys-589	274	4	.	.	PROPN
bionys-589	274	5	,	,	PUNCT
bionys-589	274	6	tappia	tappia	PROPN
bionys-589	274	7	,	,	PUNCT
bionys-589	274	8	p.s	p.s	PROPN
bionys-589	274	9	.	.	PROPN
bionys-589	274	10	,	,	PUNCT
bionys-589	274	11	bux	bux	PROPN
bionys-589	274	12	,	,	PUNCT
bionys-589	274	13	r.a	r.a	PROPN
bionys-589	274	14	.	.	PROPN
bionys-589	274	15	,	,	PUNCT
bionys-589	274	16	moyer	moyer	PROPN
bionys-589	274	17	,	,	PUNCT
bionys-589	274	18	d.	d.	PROPN
bionys-589	274	19	,	,	PUNCT
bionys-589	274	20	huang	huang	PROPN
bionys-589	274	21	,	,	PUNCT
bionys-589	274	22	g.	g.	PROPN
bionys-589	274	23	,	,	PUNCT
bionys-589	274	24	joubert	joubert	PROPN
bionys-589	274	25	,	,	PUNCT
bionys-589	274	26	p.	p.	PROPN
bionys-589	274	27	,	,	PUNCT
bionys-589	274	28	miller	miller	PROPN
bionys-589	274	29	,	,	PUNCT
bionys-589	274	30	d.w	d.w	PROPN
bionys-589	274	31	.	.	PROPN
bionys-589	274	32	,	,	PUNCT
bionys-589	274	33	ramjiawan	ramjiawan	PROPN
bionys-589	274	34	,	,	PUNCT
bionys-589	274	35	b.	b.	PROPN
bionys-589	274	36	,	,	PUNCT
bionys-589	274	37	&	&	CCONJ
bionys-589	274	38	sitar	sitar	PROPN
bionys-589	274	39	,	,	PUNCT
bionys-589	274	40	d.s	d.s	PROPN
bionys-589	274	41	.	.	PROPN
bionys-589	274	42	(	(	PUNCT
bionys-589	274	43	2021	2021	NUM
bionys-589	274	44	)	)	PUNCT
bionys-589	274	45	.	.	PUNCT
bionys-589	275	1	use	use	NOUN
bionys-589	275	2	of	of	ADP
bionys-589	275	3	amantadine	amantadine	NOUN
bionys-589	275	4	in	in	ADP
bionys-589	275	5	the	the	DET
bionys-589	275	6	evaluation	evaluation	NOUN
bionys-589	275	7	of	of	ADP
bionys-589	275	8	response	response	NOUN
bionys-589	275	9	to	to	ADP
bionys-589	275	10	chemotherapy	chemotherapy	NOUN
bionys-589	275	11	in	in	ADP
bionys-589	275	12	lung	lung	NOUN
bionys-589	275	13	cancer	cancer	NOUN
bionys-589	275	14	:	:	PUNCT
bionys-589	275	15	a	a	DET
bionys-589	275	16	pilot	pilot	NOUN
bionys-589	275	17	study	study	NOUN
bionys-589	275	18	.	.	PUNCT
bionys-589	276	1	future	future	ADJ
bionys-589	276	2	science	science	NOUN
bionys-589	276	3	oa	oa	NOUN
bionys-589	276	4	,	,	PUNCT
bionys-589	276	5	7(4	7(4	NUM
bionys-589	276	6	)	)	PUNCT
bionys-589	276	7	,	,	PUNCT
bionys-589	276	8	fso679	fso679	PROPN
bionys-589	276	9	.	.	PUNCT
bionys-589	277	1	doi	doi	NOUN
bionys-589	277	2	:	:	PUNCT
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bionys-589	277	4	/	/	SYM
bionys-589	277	5	fsoa-20200176	fsoa-20200176	NOUN
bionys-589	277	6	.	.	PUNCT
bionys-589	278	1	mourtas	mourtas	PROPN
bionys-589	278	2	,	,	PUNCT
bionys-589	278	3	s.	s.	PROPN
bionys-589	278	4	,	,	PUNCT
bionys-589	278	5	lazar	lazar	PROPN
bionys-589	278	6	,	,	PUNCT
bionys-589	278	7	a.n	a.n	PROPN
bionys-589	278	8	.	.	PROPN
bionys-589	278	9	,	,	PUNCT
bionys-589	278	10	markoutsa	markoutsa	PROPN
bionys-589	278	11	,	,	PUNCT
bionys-589	278	12	e.	e.	PROPN
bionys-589	278	13	,	,	PUNCT
bionys-589	278	14	duyckaerts	duyckaert	NOUN
bionys-589	278	15	,	,	PUNCT
bionys-589	278	16	c.	c.	NOUN
bionys-589	278	17	,	,	PUNCT
bionys-589	278	18	&	&	CCONJ
bionys-589	278	19	antimisiaris	antimisiaris	PROPN
bionys-589	278	20	,	,	PUNCT
bionys-589	278	21	s.g	s.g	PROPN
bionys-589	278	22	.	.	PROPN
bionys-589	278	23	(	(	PUNCT
bionys-589	278	24	2014	2014	NUM
bionys-589	278	25	)	)	PUNCT
bionys-589	278	26	.	.	PUNCT
bionys-589	279	1	multifunctional	multifunctional	ADJ
bionys-589	279	2	nanoliposomes	nanoliposome	NOUN
bionys-589	279	3	with	with	ADP
bionys-589	279	4	curcumin	curcumin	NOUN
bionys-589	279	5	–	–	PUNCT
bionys-589	279	6	lipid	lipid	ADJ
bionys-589	279	7	derivative	derivative	NOUN
bionys-589	279	8	and	and	CCONJ
bionys-589	279	9	brain	brain	NOUN
bionys-589	279	10	targeting	target	VERB
bionys-589	279	11	functionality	functionality	NOUN
bionys-589	279	12	with	with	ADP
bionys-589	279	13	potential	potential	ADJ
bionys-589	279	14	applications	application	NOUN
bionys-589	279	15	for	for	ADP
bionys-589	279	16	alzheimer	alzheimer	PROPN
bionys-589	279	17	disease	disease	NOUN
bionys-589	279	18	.	.	PUNCT
bionys-589	280	1	european	european	PROPN
bionys-589	280	2	journal	journal	PROPN
bionys-589	280	3	of	of	ADP
bionys-589	280	4	medicinal	medicinal	ADJ
bionys-589	280	5	chemistry	chemistry	NOUN
bionys-589	280	6	,	,	PUNCT
bionys-589	280	7	80	80	NUM
bionys-589	280	8	,	,	PUNCT
bionys-589	280	9	175	175	NUM
bionys-589	280	10	-	-	SYM
bionys-589	280	11	183	183	NUM
bionys-589	280	12	.	.	PUNCT
bionys-589	281	1	doi	doi	NOUN
bionys-589	281	2	:	:	PUNCT
bionys-589	281	3	10.1016	10.1016	NUM
bionys-589	281	4	/	/	SYM
bionys-589	281	5	j.	j.	PROPN
bionys-589	281	6	ejmech.2014.04.050	ejmech.2014.04.050	PROPN
bionys-589	281	7	.	.	PROPN
bionys-589	281	8	nair	nair	PROPN
bionys-589	281	9	,	,	PUNCT
bionys-589	281	10	p.	p.	PROPN
bionys-589	281	11	,	,	PUNCT
bionys-589	281	12	malhotra	malhotra	PROPN
bionys-589	281	13	,	,	PUNCT
bionys-589	281	14	a.	a.	PROPN
bionys-589	281	15	,	,	PUNCT
bionys-589	281	16	&	&	CCONJ
bionys-589	281	17	dhawan	dhawan	PROPN
bionys-589	281	18	,	,	PUNCT
bionys-589	281	19	d.k	d.k	PROPN
bionys-589	281	20	.	.	PROPN
bionys-589	281	21	(	(	PUNCT
bionys-589	281	22	2015	2015	NUM
bionys-589	281	23	)	)	PUNCT
bionys-589	281	24	.	.	PUNCT
bionys-589	282	1	curcumin	curcumin	NOUN
bionys-589	282	2	and	and	CCONJ
bionys-589	282	3	quercetin	quercetin	NOUN
bionys-589	282	4	trigger	trigger	NOUN
bionys-589	282	5	apoptosis	apoptosis	NOUN
bionys-589	282	6	during	during	ADP
bionys-589	282	7	benzo(a)pyrene	benzo(a)pyrene	VERB
bionys-589	282	8	-	-	PUNCT
bionys-589	282	9	induced	induced	ADJ
bionys-589	282	10	lung	lung	NOUN
bionys-589	282	11	carcinogenesis	carcinogenesis	NOUN
bionys-589	282	12	.	.	PUNCT
bionys-589	283	1	molecular	molecular	ADJ
bionys-589	283	2	and	and	CCONJ
bionys-589	283	3	cellular	cellular	ADJ
bionys-589	283	4	biochemistry	biochemistry	NOUN
bionys-589	283	5	,	,	PUNCT
bionys-589	283	6	400	400	NUM
bionys-589	283	7	,	,	PUNCT
bionys-589	283	8	51	51	NUM
bionys-589	283	9	-	-	SYM
bionys-589	283	10	56	56	NUM
bionys-589	283	11	.	.	PUNCT
bionys-589	284	1	doi	doi	NOUN
bionys-589	284	2	:	:	PUNCT
bionys-589	284	3	10.1007	10.1007	NUM
bionys-589	284	4	/	/	SYM
bionys-589	284	5	s11010	s11010	NOUN
bionys-589	284	6	-	-	PUNCT
bionys-589	284	7	014	014	NUM
bionys-589	284	8	-	-	PUNCT
bionys-589	284	9	2261	2261	NUM
bionys-589	284	10	-	-	SYM
bionys-589	284	11	6	6	NUM
bionys-589	284	12	.	.	PUNCT
bionys-589	285	1	nazari	nazari	PROPN
bionys-589	285	2	,	,	PUNCT
bionys-589	285	3	q.a	q.a	PROPN
bionys-589	285	4	.	.	PROPN
bionys-589	285	5	,	,	PUNCT
bionys-589	285	6	takada	takada	PROPN
bionys-589	285	7	-	-	PUNCT
bionys-589	285	8	takatori	takatori	PROPN
bionys-589	285	9	,	,	PUNCT
bionys-589	285	10	y.	y.	NOUN
bionys-589	285	11	,	,	PUNCT
bionys-589	285	12	hashimoto	hashimoto	NOUN
bionys-589	285	13	,	,	PUNCT
bionys-589	285	14	t.	t.	PROPN
bionys-589	285	15	,	,	PUNCT
bionys-589	285	16	imaizumi	imaizumi	PROPN
bionys-589	285	17	,	,	PUNCT
bionys-589	285	18	a.	a.	NOUN
bionys-589	285	19	,	,	PUNCT
bionys-589	285	20	izumi	izumi	PROPN
bionys-589	285	21	,	,	PUNCT
bionys-589	285	22	y.	y.	PROPN
bionys-589	285	23	,	,	PUNCT
bionys-589	285	24	akaike	akaike	ADJ
bionys-589	285	25	,	,	PUNCT
bionys-589	285	26	a.	a.	NOUN
bionys-589	285	27	,	,	PUNCT
bionys-589	285	28	&	&	CCONJ
bionys-589	285	29	kume	kume	PROPN
bionys-589	285	30	,	,	PUNCT
bionys-589	285	31	t.	t.	PROPN
bionys-589	285	32	(	(	PUNCT
bionys-589	285	33	2014	2014	NUM
bionys-589	285	34	)	)	PUNCT
bionys-589	285	35	.	.	PUNCT
bionys-589	286	1	potential	potential	ADJ
bionys-589	286	2	protective	protective	ADJ
bionys-589	286	3	effect	effect	NOUN
bionys-589	286	4	of	of	ADP
bionys-589	286	5	highly	highly	ADV
bionys-589	286	6	bioavailable	bioavailable	ADJ
bionys-589	286	7	curcumin	curcumin	NOUN
bionys-589	286	8	on	on	ADP
bionys-589	286	9	an	an	DET
bionys-589	286	10	oxidative	oxidative	ADJ
bionys-589	286	11	stress	stress	NOUN
bionys-589	286	12	model	model	NOUN
bionys-589	286	13	induced	induce	VERB
bionys-589	286	14	by	by	ADP
bionys-589	286	15	microinjection	microinjection	NOUN
bionys-589	286	16	of	of	ADP
bionys-589	286	17	sodium	sodium	NOUN
bionys-589	286	18	nitroprusside	nitroprusside	ADV
bionys-589	286	19	in	in	ADP
bionys-589	286	20	mice	mice	NOUN
bionys-589	286	21	brain	brain	NOUN
bionys-589	286	22	.	.	PUNCT
bionys-589	287	1	food	food	NOUN
bionys-589	287	2	&	&	CCONJ
bionys-589	287	3	function	function	PROPN
bionys-589	287	4	,	,	PUNCT
bionys-589	287	5	5(5	5(5	NUM
bionys-589	287	6	)	)	PUNCT
bionys-589	287	7	,	,	PUNCT
bionys-589	287	8	984	984	NUM
bionys-589	287	9	-	-	SYM
bionys-589	287	10	989	989	NUM
bionys-589	287	11	.	.	PUNCT
bionys-589	287	12	doi	doi	NOUN
bionys-589	287	13	:	:	PUNCT
bionys-589	287	14	10.1039	10.1039	NUM
bionys-589	287	15	/	/	SYM
bionys-589	287	16	c4fo00009a	c4fo00009a	PROPN
bionys-589	287	17	.	.	PUNCT
bionys-589	287	18	parkinson	parkinson	PROPN
bionys-589	287	19	,	,	PUNCT
bionys-589	287	20	j.	j.	PROPN
bionys-589	287	21	(	(	PUNCT
bionys-589	287	22	2002	2002	NUM
bionys-589	287	23	)	)	PUNCT
bionys-589	287	24	.	.	PUNCT
bionys-589	288	1	an	an	DET
bionys-589	288	2	essay	essay	NOUN
bionys-589	288	3	on	on	ADP
bionys-589	288	4	the	the	DET
bionys-589	288	5	shaking	shake	VERB
bionys-589	288	6	palsy	palsy	NOUN
bionys-589	288	7	.	.	PUNCT
bionys-589	289	1	the	the	DET
bionys-589	289	2	journal	journal	NOUN
bionys-589	289	3	of	of	ADP
bionys-589	289	4	neuropsychiatry	neuropsychiatry	NOUN
bionys-589	289	5	and	and	CCONJ
bionys-589	289	6	clinical	clinical	ADJ
bionys-589	289	7	neurosciences	neuroscience	NOUN
bionys-589	289	8	,	,	PUNCT
bionys-589	289	9	14(2	14(2	NUM
bionys-589	289	10	)	)	PUNCT
bionys-589	289	11	,	,	PUNCT
bionys-589	289	12	223	223	NUM
bionys-589	289	13	-	-	SYM
bionys-589	289	14	236	236	NUM
bionys-589	289	15	.	.	PUNCT
bionys-589	290	1	doi	doi	NOUN
bionys-589	290	2	:	:	PUNCT
bionys-589	290	3	10.1176/	10.1176/	NUM
bionys-589	290	4	jnp.14.2.223	jnp.14.2.223	PROPN
bionys-589	290	5	.	.	PUNCT
bionys-589	290	6	parkinson	parkinson	PROPN
bionys-589	290	7	’s	’s	PART
bionys-589	290	8	news	news	NOUN
bionys-589	290	9	today	today	NOUN
bionys-589	290	10	(	(	PUNCT
bionys-589	290	11	2021	2021	NUM
bionys-589	290	12	)	)	PUNCT
bionys-589	290	13	.	.	PUNCT
bionys-589	291	1	parkinson	parkinson	NOUN
bionys-589	291	2	’s	’s	PART
bionys-589	291	3	disease	disease	NOUN
bionys-589	291	4	statistics	statistic	NOUN
bionys-589	291	5	.	.	PUNCT
bionys-589	292	1	retrieved	retrieve	VERB
bionys-589	292	2	from	from	ADP
bionys-589	292	3	https://parkinsonsnewstoday.com/parkinsons-disease-statistics	https://parkinsonsnewstoday.com/parkinsons-disease-statistic	NOUN
bionys-589	292	4	(	(	PUNCT
bionys-589	292	5	accessed	access	VERB
bionys-589	292	6	on	on	ADP
bionys-589	292	7	8	8	NUM
bionys-589	292	8	december	december	PROPN
bionys-589	292	9	2021	2021	NUM
bionys-589	292	10	)	)	PUNCT
bionys-589	292	11	.	.	PUNCT
bionys-589	293	1	poewe	poewe	PROPN
bionys-589	293	2	,	,	PUNCT
bionys-589	293	3	w.	w.	PROPN
bionys-589	293	4	,	,	PUNCT
bionys-589	293	5	seppi	seppi	PROPN
bionys-589	293	6	,	,	PUNCT
bionys-589	293	7	k.	k.	PROPN
bionys-589	293	8	,	,	PUNCT
bionys-589	293	9	tanner	tanner	NOUN
bionys-589	293	10	,	,	PUNCT
bionys-589	293	11	c.m	c.m	PROPN
bionys-589	293	12	.	.	PROPN
bionys-589	293	13	,	,	PUNCT
bionys-589	293	14	halliday	halliday	PROPN
bionys-589	293	15	,	,	PUNCT
bionys-589	293	16	g.m	g.m	PROPN
bionys-589	293	17	.	.	PROPN
bionys-589	293	18	,	,	PUNCT
bionys-589	293	19	brundin	brundin	VERB
bionys-589	293	20	,	,	PUNCT
bionys-589	293	21	p.	p.	NOUN
bionys-589	293	22	,	,	PUNCT
bionys-589	293	23	volkmann	volkmann	PROPN
bionys-589	293	24	,	,	PUNCT
bionys-589	293	25	j.	j.	PROPN
bionys-589	293	26	,	,	PUNCT
bionys-589	293	27	schrag	schrag	PROPN
bionys-589	293	28	,	,	PUNCT
bionys-589	293	29	a.e	a.e	PROPN
bionys-589	293	30	.	.	PROPN
bionys-589	293	31	,	,	PUNCT
bionys-589	293	32	&	&	CCONJ
bionys-589	293	33	lang	lang	PROPN
bionys-589	293	34	,	,	PUNCT
bionys-589	293	35	a.e	a.e	PROPN
bionys-589	293	36	.	.	PROPN
bionys-589	293	37	(	(	PUNCT
bionys-589	293	38	2017	2017	NUM
bionys-589	293	39	)	)	PUNCT
bionys-589	293	40	.	.	PUNCT
bionys-589	294	1	parkinson	parkinson	NOUN
bionys-589	294	2	disease	disease	PROPN
bionys-589	294	3	.	.	PUNCT
bionys-589	295	1	nature	nature	NOUN
bionys-589	295	2	reviews	review	NOUN
bionys-589	295	3	disease	disease	NOUN
bionys-589	295	4	primers	primer	NOUN
bionys-589	295	5	,	,	PUNCT
bionys-589	295	6	3(1	3(1	NUM
bionys-589	295	7	)	)	PUNCT
bionys-589	295	8	,	,	PUNCT
bionys-589	295	9	1	1	NUM
bionys-589	295	10	-	-	SYM
bionys-589	295	11	21	21	NUM
bionys-589	295	12	.	.	PUNCT
bionys-589	296	1	https://doi	https://doi	NOUN
bionys-589	296	2	.	.	PUNCT
bionys-589	296	3	org/10.1038	org/10.1038	PROPN
bionys-589	296	4	/	/	SYM
bionys-589	296	5	nrdp.2017.13	nrdp.2017.13	PROPN
bionys-589	296	6	rascol	rascol	NOUN
bionys-589	296	7	,	,	PUNCT
bionys-589	296	8	o.	o.	PROPN
bionys-589	296	9	,	,	PUNCT
bionys-589	296	10	fabbri	fabbri	NOUN
bionys-589	296	11	,	,	PUNCT
bionys-589	296	12	m.	m.	NOUN
bionys-589	296	13	,	,	PUNCT
bionys-589	296	14	&	&	CCONJ
bionys-589	296	15	poewe	poewe	PROPN
bionys-589	296	16	,	,	PUNCT
bionys-589	296	17	w.	w.	NOUN
bionys-589	296	18	(	(	PUNCT
bionys-589	296	19	2021	2021	NUM
bionys-589	296	20	)	)	PUNCT
bionys-589	296	21	.	.	PUNCT
bionys-589	297	1	amantadine	amantadine	NOUN
bionys-589	297	2	in	in	ADP
bionys-589	297	3	the	the	DET
bionys-589	297	4	treatment	treatment	NOUN
bionys-589	297	5	of	of	ADP
bionys-589	297	6	parkinson	parkinson	NOUN
bionys-589	297	7	's	's	PART
bionys-589	297	8	disease	disease	NOUN
bionys-589	297	9	and	and	CCONJ
bionys-589	297	10	other	other	ADJ
bionys-589	297	11	movement	movement	NOUN
bionys-589	297	12	disorders	disorder	NOUN
bionys-589	297	13	.	.	PUNCT
bionys-589	298	1	the	the	DET
bionys-589	298	2	lancet	lancet	PROPN
bionys-589	298	3	neurology	neurology	NOUN
bionys-589	298	4	,	,	PUNCT
bionys-589	298	5	20(12	20(12	NUM
bionys-589	298	6	)	)	PUNCT
bionys-589	298	7	,	,	PUNCT
bionys-589	298	8	1048	1048	NUM
bionys-589	298	9	-	-	SYM
bionys-589	298	10	1056	1056	NUM
bionys-589	298	11	.	.	PUNCT
bionys-589	299	1	doi	doi	NOUN
bionys-589	299	2	:	:	PUNCT
bionys-589	299	3	10.1016	10.1016	NUM
bionys-589	299	4	/	/	SYM
bionys-589	299	5	s14744422(21)00249	s14744422(21)00249	NOUN
bionys-589	299	6	-	-	PUNCT
bionys-589	299	7	0	0	NUM
bionys-589	299	8	.	.	PUNCT
bionys-589	300	1	simon	simon	PROPN
bionys-589	300	2	,	,	PUNCT
bionys-589	300	3	d.k	d.k	PROPN
bionys-589	300	4	.	.	PROPN
bionys-589	300	5	,	,	PUNCT
bionys-589	300	6	tanner	tanner	NOUN
bionys-589	300	7	,	,	PUNCT
bionys-589	300	8	c.m	c.m	PROPN
bionys-589	300	9	.	.	PROPN
bionys-589	300	10	,	,	PUNCT
bionys-589	300	11	&	&	CCONJ
bionys-589	300	12	brundin	brundin	VERB
bionys-589	300	13	,	,	PUNCT
bionys-589	300	14	p.	p.	NOUN
bionys-589	300	15	(	(	PUNCT
bionys-589	300	16	2020	2020	NUM
bionys-589	300	17	)	)	PUNCT
bionys-589	300	18	.	.	PUNCT
bionys-589	301	1	parkinson	parkinson	NOUN
bionys-589	301	2	disease	disease	NOUN
bionys-589	301	3	epidemiology	epidemiology	NOUN
bionys-589	301	4	,	,	PUNCT
bionys-589	301	5	pathology	pathology	NOUN
bionys-589	301	6	,	,	PUNCT
bionys-589	301	7	genetics	genetic	NOUN
bionys-589	301	8	,	,	PUNCT
bionys-589	301	9	and	and	CCONJ
bionys-589	301	10	pathophysiology	pathophysiology	NOUN
bionys-589	301	11	.	.	PUNCT
bionys-589	302	1	clinics	clinic	NOUN
bionys-589	302	2	in	in	ADP
bionys-589	302	3	geriatric	geriatric	ADJ
bionys-589	302	4	medicine	medicine	NOUN
bionys-589	302	5	,	,	PUNCT
bionys-589	302	6	36(1	36(1	NUM
bionys-589	302	7	)	)	PUNCT
bionys-589	302	8	,	,	PUNCT
bionys-589	302	9	1	1	NUM
bionys-589	302	10	-	-	SYM
bionys-589	302	11	12	12	NUM
bionys-589	302	12	.	.	PUNCT
bionys-589	303	1	doi	doi	NOUN
bionys-589	303	2	:	:	PUNCT
bionys-589	303	3	10.1016	10.1016	NUM
bionys-589	303	4	/	/	SYM
bionys-589	303	5	j.	j.	PROPN
bionys-589	303	6	cger.2019.08.002	cger.2019.08.002	PROPN
bionys-589	303	7	.	.	PUNCT
bionys-589	304	1	staničová	staničová	PROPN
bionys-589	304	2	,	,	PUNCT
bionys-589	304	3	j.	j.	PROPN
bionys-589	304	4	,	,	PUNCT
bionys-589	304	5	miškovský	miškovský	PROPN
bionys-589	304	6	,	,	PUNCT
bionys-589	304	7	p.	p.	PROPN
bionys-589	304	8	,	,	PUNCT
bionys-589	304	9	&	&	CCONJ
bionys-589	304	10	šutiak	šutiak	PROPN
bionys-589	304	11	,	,	PUNCT
bionys-589	304	12	v.	v.	PROPN
bionys-589	304	13	(	(	PUNCT
bionys-589	304	14	2001	2001	NUM
bionys-589	304	15	)	)	PUNCT
bionys-589	304	16	.	.	PUNCT
bionys-589	305	1	amantadine	amantadine	NOUN
bionys-589	305	2	:	:	PUNCT
bionys-589	305	3	an	an	DET
bionys-589	305	4	antiviral	antiviral	ADJ
bionys-589	305	5	and	and	CCONJ
bionys-589	305	6	antiparkinsonian	antiparkinsonian	ADJ
bionys-589	305	7	agent	agent	NOUN
bionys-589	305	8	.	.	PUNCT
bionys-589	306	1	veterinární	veterinární	PROPN
bionys-589	306	2	medicína	medicína	PROPN
bionys-589	306	3	,	,	PUNCT
bionys-589	306	4	czech	czech	PROPN
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bionys-589	306	6	of	of	ADP
bionys-589	306	7	agricultural	agricultural	ADJ
bionys-589	306	8	sciences	science	NOUN
bionys-589	306	9	,	,	PUNCT
bionys-589	306	10	46(9	46(9	NOUN
bionys-589	306	11	)	)	PUNCT
bionys-589	306	12	,	,	PUNCT
bionys-589	306	13	244	244	NUM
bionys-589	306	14	-	-	SYM
bionys-589	306	15	256	256	NUM
bionys-589	306	16	.	.	PUNCT
bionys-589	307	1	takahashi	takahashi	PROPN
bionys-589	307	2	,	,	PUNCT
bionys-589	307	3	m.	m.	NOUN
bionys-589	307	4	,	,	PUNCT
bionys-589	307	5	uechi	uechi	PROPN
bionys-589	307	6	,	,	PUNCT
bionys-589	307	7	s.	s.	PROPN
bionys-589	307	8	,	,	PUNCT
bionys-589	307	9	takara	takara	PROPN
bionys-589	307	10	,	,	PUNCT
bionys-589	307	11	k.	k.	PROPN
bionys-589	307	12	,	,	PUNCT
bionys-589	307	13	asikin	asikin	PROPN
bionys-589	307	14	,	,	PUNCT
bionys-589	307	15	y.	y.	PROPN
bionys-589	307	16	,	,	PUNCT
bionys-589	307	17	&	&	CCONJ
bionys-589	307	18	wada	wada	PROPN
bionys-589	307	19	,	,	PUNCT
bionys-589	307	20	k.	k.	PROPN
bionys-589	307	21	(	(	PUNCT
bionys-589	307	22	2009	2009	NUM
bionys-589	307	23	)	)	PUNCT
bionys-589	307	24	.	.	PUNCT
bionys-589	308	1	evaluation	evaluation	NOUN
bionys-589	308	2	of	of	ADP
bionys-589	308	3	an	an	DET
bionys-589	308	4	oral	oral	ADJ
bionys-589	308	5	carrier	carrier	NOUN
bionys-589	308	6	system	system	NOUN
bionys-589	308	7	in	in	ADP
bionys-589	308	8	rats	rat	NOUN
bionys-589	308	9	:	:	PUNCT
bionys-589	308	10	bioavailability	bioavailability	NOUN
bionys-589	308	11	and	and	CCONJ
bionys-589	308	12	antioxidant	antioxidant	ADJ
bionys-589	308	13	properties	property	NOUN
bionys-589	308	14	of	of	ADP
bionys-589	308	15	liposome	liposome	NOUN
bionys-589	308	16	-	-	PUNCT
bionys-589	308	17	encapsulated	encapsulate	VERB
bionys-589	308	18	curcumin	curcumin	NOUN
bionys-589	308	19	.	.	PUNCT
bionys-589	309	1	journal	journal	PROPN
bionys-589	309	2	of	of	ADP
bionys-589	309	3	agricultural	agricultural	ADJ
bionys-589	309	4	and	and	CCONJ
bionys-589	309	5	food	food	NOUN
bionys-589	309	6	chemistry	chemistry	NOUN
bionys-589	309	7	,	,	PUNCT
bionys-589	309	8	57(19	57(19	PROPN
bionys-589	309	9	)	)	PUNCT
bionys-589	309	10	,	,	PUNCT
bionys-589	309	11	91419146	91419146	NUM
bionys-589	309	12	.	.	PUNCT
bionys-589	310	1	doi	doi	NOUN
bionys-589	310	2	:	:	PUNCT
bionys-589	310	3	10.1021	10.1021	NUM
bionys-589	310	4	/	/	SYM
bionys-589	310	5	jf9013923	jf9013923	PROPN
bionys-589	310	6	.	.	PUNCT
bionys-589	311	1	tonda	tonda	PROPN
bionys-589	311	2	-	-	PUNCT
bionys-589	311	3	turo	turo	PROPN
bionys-589	311	4	,	,	PUNCT
bionys-589	311	5	c.	c.	PROPN
bionys-589	311	6	,	,	PUNCT
bionys-589	311	7	origlia	origlia	PROPN
bionys-589	311	8	,	,	PUNCT
bionys-589	311	9	n.	n.	NOUN
bionys-589	311	10	,	,	PUNCT
bionys-589	311	11	mattu	mattu	ADJ
bionys-589	311	12	,	,	PUNCT
bionys-589	311	13	c.	c.	PROPN
bionys-589	311	14	,	,	PUNCT
bionys-589	311	15	accorroni	accorroni	PROPN
bionys-589	311	16	,	,	PUNCT
bionys-589	311	17	a.	a.	PROPN
bionys-589	311	18	,	,	PUNCT
bionys-589	311	19	&	&	CCONJ
bionys-589	311	20	chiono	chiono	PROPN
bionys-589	311	21	,	,	PUNCT
bionys-589	311	22	v.	v.	PROPN
bionys-589	311	23	(	(	PUNCT
bionys-589	311	24	2018	2018	NUM
bionys-589	311	25	)	)	PUNCT
bionys-589	311	26	.	.	PUNCT
bionys-589	312	1	current	current	ADJ
bionys-589	312	2	limitations	limitation	NOUN
bionys-589	312	3	in	in	ADP
bionys-589	312	4	the	the	DET
bionys-589	312	5	treatment	treatment	NOUN
bionys-589	312	6	of	of	ADP
bionys-589	312	7	parkinson	parkinson	NOUN
bionys-589	312	8	's	's	PART
bionys-589	312	9	and	and	CCONJ
bionys-589	312	10	alzheimer	alzheimer	PROPN
bionys-589	312	11	's	's	PART
bionys-589	312	12	diseases	disease	NOUN
bionys-589	312	13	:	:	PUNCT
bionys-589	312	14	state	state	NOUN
bionys-589	312	15	-	-	PUNCT
bionys-589	312	16	of	of	ADP
bionys-589	312	17	-	-	PUNCT
bionys-589	312	18	the	the	DET
bionys-589	312	19	-	-	PUNCT
bionys-589	312	20	art	art	NOUN
bionys-589	312	21	and	and	CCONJ
bionys-589	312	22	future	future	ADJ
bionys-589	312	23	perspective	perspective	NOUN
bionys-589	312	24	of	of	ADP
bionys-589	312	25	polymeric	polymeric	ADJ
bionys-589	312	26	carriers	carrier	NOUN
bionys-589	312	27	.	.	PUNCT
bionys-589	313	1	current	current	ADJ
bionys-589	313	2	medicinal	medicinal	ADJ
bionys-589	313	3	chemistry	chemistry	NOUN
bionys-589	313	4	,	,	PUNCT
bionys-589	313	5	25(41	25(41	NUM
bionys-589	313	6	)	)	PUNCT
bionys-589	313	7	,	,	PUNCT
bionys-589	313	8	5755	5755	NUM
bionys-589	313	9	-	-	SYM
bionys-589	313	10	5771	5771	NUM
bionys-589	313	11	.	.	PUNCT
bionys-589	314	1	doi	doi	NOUN
bionys-589	314	2	:	:	PUNCT
bionys-589	314	3	10.2174/092986732566618022112	10.2174/092986732566618022112	NUM
bionys-589	314	4	5759	5759	NUM
bionys-589	314	5	.	.	PUNCT
bionys-589	315	1	tsai	tsai	PROPN
bionys-589	315	2	,	,	PUNCT
bionys-589	315	3	y.m	y.m	PROPN
bionys-589	315	4	.	.	PROPN
bionys-589	315	5	,	,	PUNCT
bionys-589	315	6	chien	chien	PROPN
bionys-589	315	7	,	,	PUNCT
bionys-589	315	8	c.f	c.f	PROPN
bionys-589	315	9	.	.	PROPN
bionys-589	315	10	,	,	PUNCT
bionys-589	315	11	lin	lin	PROPN
bionys-589	315	12	,	,	PUNCT
bionys-589	315	13	l.c	l.c	PROPN
bionys-589	315	14	.	.	PROPN
bionys-589	315	15	,	,	PUNCT
bionys-589	315	16	&	&	CCONJ
bionys-589	315	17	tsai	tsai	PROPN
bionys-589	315	18	,	,	PUNCT
bionys-589	315	19	t.h	t.h	PROPN
bionys-589	315	20	.	.	PUNCT
bionys-589	315	21	(	(	PUNCT
bionys-589	315	22	2011	2011	NUM
bionys-589	315	23	)	)	PUNCT
bionys-589	315	24	.	.	PUNCT
bionys-589	316	1	curcumin	curcumin	NOUN
bionys-589	316	2	and	and	CCONJ
bionys-589	316	3	its	its	PRON
bionys-589	316	4	nanoformulation	nanoformulation	NOUN
bionys-589	316	5	:	:	PUNCT
bionys-589	316	6	the	the	DET
bionys-589	316	7	kinetics	kinetic	NOUN
bionys-589	316	8	of	of	ADP
bionys-589	316	9	tissue	tissue	NOUN
bionys-589	316	10	distribution	distribution	NOUN
bionys-589	316	11	and	and	CCONJ
bionys-589	316	12	blood	blood	NOUN
bionys-589	316	13	–	–	PUNCT
bionys-589	316	14	brain	brain	NOUN
bionys-589	316	15	barrier	barrier	NOUN
bionys-589	316	16	penetration	penetration	NOUN
bionys-589	316	17	.	.	PUNCT
bionys-589	317	1	international	international	ADJ
bionys-589	317	2	journal	journal	PROPN
bionys-589	317	3	of	of	ADP
bionys-589	317	4	pharmaceutics	pharmaceutic	NOUN
bionys-589	317	5	,	,	PUNCT
bionys-589	317	6	416(1	416(1	NUM
bionys-589	317	7	)	)	PUNCT
bionys-589	317	8	,	,	PUNCT
bionys-589	317	9	331	331	NUM
bionys-589	317	10	-	-	SYM
bionys-589	317	11	338	338	NUM
bionys-589	317	12	.	.	PUNCT
bionys-589	318	1	doi	doi	NOUN
bionys-589	318	2	:	:	PUNCT
bionys-589	318	3	10.1016	10.1016	NUM
bionys-589	318	4	/	/	SYM
bionys-589	318	5	j.	j.	PROPN
bionys-589	318	6	ijpharm.2011.06.030	ijpharm.2011.06.030	PROPN
bionys-589	318	7	.	.	PUNCT
bionys-589	319	1	yadav	yadav	PROPN
bionys-589	319	2	,	,	PUNCT
bionys-589	319	3	v.k	v.k	PROPN
bionys-589	319	4	.	.	PROPN
bionys-589	319	5	,	,	PUNCT
bionys-589	319	6	dhanasekaran	dhanasekaran	PROPN
bionys-589	319	7	,	,	PUNCT
bionys-589	319	8	s.	s.	PROPN
bionys-589	319	9	,	,	PUNCT
bionys-589	319	10	choudhary	choudhary	PROPN
bionys-589	319	11	,	,	PUNCT
bionys-589	319	12	n.	n.	PROPN
bionys-589	319	13	,	,	PUNCT
bionys-589	319	14	nathiya	nathiya	PROPN
bionys-589	319	15	,	,	PUNCT
bionys-589	319	16	d.	d.	PROPN
bionys-589	319	17	,	,	PUNCT
bionys-589	319	18	thakur	thakur	PROPN
bionys-589	319	19	,	,	PUNCT
bionys-589	319	20	v.	v.	PROPN
bionys-589	319	21	,	,	PUNCT
bionys-589	319	22	gupta	gupta	PROPN
bionys-589	319	23	,	,	PUNCT
bionys-589	319	24	r.	r.	PROPN
bionys-589	319	25	,	,	PUNCT
bionys-589	319	26	pramanik	pramanik	VERB
bionys-589	319	27	,	,	PUNCT
bionys-589	319	28	s.	s.	PROPN
bionys-589	319	29	,	,	PUNCT
bionys-589	319	30	kumar	kumar	PROPN
bionys-589	319	31	,	,	PUNCT
bionys-589	319	32	p.	p.	PROPN
bionys-589	319	33	,	,	PUNCT
bionys-589	319	34	gupta	gupta	PROPN
bionys-589	319	35	,	,	PUNCT
bionys-589	319	36	n.	n.	NOUN
bionys-589	319	37	,	,	PUNCT
bionys-589	319	38	&	&	CCONJ
bionys-589	319	39	patel	patel	PROPN
bionys-589	319	40	,	,	PUNCT
bionys-589	319	41	a.	a.	NOUN
bionys-589	319	42	(	(	PUNCT
bionys-589	319	43	2025	2025	NUM
bionys-589	319	44	)	)	PUNCT
bionys-589	319	45	.	.	PUNCT
bionys-589	320	1	recent	recent	ADJ
bionys-589	320	2	advances	advance	NOUN
bionys-589	320	3	in	in	ADP
bionys-589	320	4	nanotechnology	nanotechnology	NOUN
bionys-589	320	5	for	for	ADP
bionys-589	320	6	parkinson	parkinson	NOUN
bionys-589	320	7	’s	’s	PART
bionys-589	320	8	disease	disease	NOUN
bionys-589	320	9	:	:	PUNCT
bionys-589	320	10	diagnosis	diagnosis	NOUN
bionys-589	320	11	,	,	PUNCT
bionys-589	320	12	treatment	treatment	NOUN
bionys-589	320	13	,	,	PUNCT
bionys-589	320	14	and	and	CCONJ
bionys-589	320	15	future	future	ADJ
bionys-589	320	16	perspectives	perspective	NOUN
bionys-589	320	17	.	.	PUNCT
bionys-589	321	1	frontiers	frontier	NOUN
bionys-589	321	2	in	in	ADP
bionys-589	321	3	medicine	medicine	NOUN
bionys-589	321	4	,	,	PUNCT
bionys-589	321	5	12	12	NUM
bionys-589	321	6	,	,	PUNCT
bionys-589	321	7	1535682	1535682	NUM
bionys-589	321	8	.	.	PUNCT
bionys-589	322	1	doi:10.3389	doi:10.3389	PROPN
bionys-589	322	2	/	/	SYM
bionys-589	322	3	fmed.2025.1535682	fmed.2025.1535682	NOUN
bionys-589	322	4	.	.	PUNCT
bionys-589	323	1	young	young	ADJ
bionys-589	323	2	,	,	PUNCT
bionys-589	323	3	n.a	n.a	PROPN
bionys-589	323	4	.	.	PROPN
bionys-589	323	5	,	,	PUNCT
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bionys-589	323	7	,	,	PUNCT
bionys-589	323	8	m.s	m.s	PROPN
bionys-589	323	9	.	.	PROPN
bionys-589	323	10	,	,	PUNCT
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bionys-589	323	12	,	,	PUNCT
bionys-589	323	13	m.	m.	NOUN
bionys-589	323	14	,	,	PUNCT
bionys-589	323	15	willis	willis	PROPN
bionys-589	323	16	,	,	PUNCT
bionys-589	323	17	w.l	w.l	PROPN
bionys-589	323	18	.	.	PROPN
bionys-589	323	19	,	,	PUNCT
bionys-589	323	20	mo	mo	PROPN
bionys-589	323	21	,	,	PUNCT
bionys-589	323	22	x.	x.	PROPN
bionys-589	323	23	,	,	PUNCT
bionys-589	323	24	valiente	valiente	PROPN
bionys-589	323	25	,	,	PUNCT
bionys-589	323	26	g.r	g.r	PROPN
bionys-589	323	27	.	.	PROPN
bionys-589	323	28	,	,	PUNCT
bionys-589	323	29	cao	cao	PROPN
bionys-589	323	30	,	,	PUNCT
bionys-589	323	31	y.	y.	PROPN
bionys-589	323	32	,	,	PUNCT
bionys-589	323	33	liu	liu	PROPN
bionys-589	323	34	,	,	PUNCT
bionys-589	323	35	z.	z.	PROPN
bionys-589	323	36	,	,	PUNCT
bionys-589	323	37	jarjour	jarjour	PROPN
bionys-589	323	38	,	,	PUNCT
bionys-589	323	39	w.n	w.n	PROPN
bionys-589	323	40	.	.	PROPN
bionys-589	323	41	,	,	PUNCT
bionys-589	323	42	&	&	CCONJ
bionys-589	323	43	wu	wu	PROPN
bionys-589	323	44	,	,	PUNCT
bionys-589	323	45	l.c	l.c	PROPN
bionys-589	323	46	.	.	PROPN
bionys-589	323	47	(	(	PUNCT
bionys-589	323	48	2014	2014	NUM
bionys-589	323	49	)	)	PUNCT
bionys-589	323	50	.	.	PUNCT
bionys-589	324	1	oral	oral	ADJ
bionys-589	324	2	administration	administration	NOUN
bionys-589	324	3	of	of	ADP
bionys-589	324	4	nano	nano	NOUN
bionys-589	324	5	-	-	PUNCT
bionys-589	324	6	emulsion	emulsion	NOUN
bionys-589	324	7	curcumin	curcumin	NOUN
bionys-589	324	8	in	in	ADP
bionys-589	324	9	mice	mouse	NOUN
bionys-589	324	10	suppresses	suppress	VERB
bionys-589	324	11	inflammatory	inflammatory	ADV
bionys-589	324	12	-	-	PUNCT
bionys-589	324	13	induced	induce	VERB
bionys-589	324	14	nfκb	nfκb	NOUN
bionys-589	324	15	signaling	signal	VERB
bionys-589	324	16	and	and	CCONJ
bionys-589	324	17	macrophage	macrophage	ADJ
bionys-589	324	18	migration	migration	NOUN
bionys-589	324	19	.	.	PUNCT
bionys-589	325	1	plos	plos	PROPN
bionys-589	325	2	one	one	NUM
bionys-589	325	3	,	,	PUNCT
bionys-589	325	4	9(11	9(11	NUM
bionys-589	325	5	)	)	PUNCT
bionys-589	325	6	,	,	PUNCT
bionys-589	325	7	e111559	e111559	PROPN
bionys-589	325	8	.	.	PUNCT
bionys-589	325	9	doi	doi	PROPN
bionys-589	325	10	:	:	PUNCT
bionys-589	325	11	10.1371	10.1371	NUM
bionys-589	325	12	/	/	SYM
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bionys-589	325	14	.	.	PUNCT