Biology, Medicine, & Natural Product Chemistry ISSN 2089-6514 (paper) Volume 11, Number 2, October 2022 | Pages: 89-109 | DOI: 10.14421/biomedich.2022.112.89-109 ISSN 2540-9328 (online) The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article Shahin Gavanji Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran University Blvd, Arqavanieh, Jey Street, P.O. Box:81595-158, Isfahan, Iran. Corresponding author gavanji.shahin2@gmail.com Manuscript received: 18 June, 2022. Revision accepted: 19 July, 2022. Published: 30 July, 2022. Abstract Herpes Simplex Viruses (HSV) viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer. For treatment of HSV infections, several physical methods and antiviral drugs are introduced, antiviral medications can also prevent or reduce outbreaks. The use of herbal medicine with antiviral effects attracted worldwide attentions. The aim of this review article is to introduce the Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes and help to evaluate and develop the new drugs from natural sources. To provide this review, relevant articles in some authentic databases including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID (scientific information database), from 1967 to April 2022 were collected, and selected botanicals from (IHP) with their scientific names and classifications and their outcome (CC50 and IC50) were introduced. In this review, scientific data regarding anti-herpetic activities of Iranian Herbal Pharmacopoeia (IHP) showed that 34 herbs from 17 families have antiviral potential to inhibit two HSV serotypes. According to families, Lamiaceae family has the highest percentage (29.41 %) of plants with antiviral activity against two HSV serotypes, also review of recent data showed that Salvia officinalis, Melissa officinalis, Securigera Securidaca, Hyssopus officinalis, Quercus brantii, Artemisia aucheri and Curcuma longa have remarkable antiviral activity against two HSV serotypes. Results of this review suggest that further research to identify and purify the bioactive compounds to determine the molecular mechanisms of action is needed. Keywords: herpes simplex; herbal medicine; pharmacopoeia; antiviral; drugs. INTRODUCTION Herpes simplex virus (HSV) belongs to the Herpesviridae family and Alphaherpesvirinae subfamily (Álvarez et al. 2020), is a global public health issue that can cause serious infection and classified into 2 serotypes: HSV-1 and HSV-2 (Gavanji et al. 2015; Pebody et al. 2004). The HSV genome consists of linear double-strand DNA, that causes primary and recurrent lesions (Reuven et al. 2003) HSV viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer (Kłysik et al. 2020; Elad et al. 2010). HSV-1 or oral herpes mainly occurs on the face, chin, lips and mouth area which infection with this serotype causes small blisters or cold sores and inflammation of oral and eye cells (Asai and Nakashima 2018; Vaghela et al. 2021), ranging from mild to severe, that may develop and increase the risk of serious illness (Farooq and Shukla 2012; Anderson et al. 2014). This type of virus usually transmitted via oral secretions or direct contact with cold sores and it can cause more severe complications such as conjunctivitis (Koujah et al.2019), herpetic stromal keratitis (HSK) (Stuart and Keadle 2012), gingivostomatitis (George and Anil 2014) and HSV-1 encephalitis (HSE) (Feola et al. 2018). HSV-2, infection is usually transmitted through sexual contacts (Zhang et al. 2022) and affects the genital area and increased risk of human immunodeficiency virus (HIV) transmission (Crisci et al. 2019). For treatment of HSV infections, several physical methods and antiviral drugs such as valacyclovir, acyclovir, penciclovir, cidofovirare, and famciclovir are introduced (Sadowski et al. 2021). The antiherpetic agents target and inactive viral DNA polymerase enzyme and inhibit the proliferation and viral replication (Li et al 2019). Acyclovir (ACV) is an antiviral agent which widely used to control and treatment of HSV infections (Wei et al. 2021). In the process of drug action, the ACV converts to acyclovir triphosphate (acyclo-GTP) and inhibits viral DNA polymerase (Fyfe et al. 1978). Nowadays, due to the resistance mutations and tolerant enzyme production, especially in people with immunodeficiency disorders, urgent need to investigate the new antiviral drugs has been highlighted (Roy et al. 2022; Majewska and Mlynarczyk-Bonikowska 2022; Chuerduangphui et al. 2022). Numerous research studies have been done to investigate the novel antiviral agents https://doi.org/10.14421/biomedich.2022.112.89-109 90 Biology, Medicine, & Natural Product Chemistry 11 (2), 2022: 89-109 (Jassim and Naji 2003), and many anti-herpetic drugs have been approved (Sadowski et al. 2021), also researchers have been contributing to develop and produce a new vaccine against herpes infection but, no preventive HSV vaccines have been approved (Krishnan and Stuart 2021). The use of herbal medicine with antiviral effects attracted worldwide attentions (Gavanji et al. 2014). Scientific research has shown that natural bioactive compounds like flavonoids, therpens, phenols and alkaloids have anti-HSV properties (Pesola and Coen 2008; Tolo 2006). Among the compounds mentioned, phenolic classes are the most commonly used for their anti-HSV properties (Treml et al. 2020) (Table1). This article is a review which provide various information about the potential antiviral activity of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV), and help to evaluate and develop the new drugs from natural sources. METHODS To provide this review, all reported herbal medicine with antiviral effects against Herpes Simplex Viruses (HSV) were collected through Iranian Herbal Pharmacopoeia (IHP) (Ghasemi Dehkordi et al. 2003) and the most relevant articles in some authentic databases including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID (scientific information database), from 1967 to April 2022 were searched. The search with different combinations of keywords were herbal medicine, herpes simplex viruses, antiviral agents, simplex virus, plants, Iran, herb. In this review, the selected articles and books were used to sets of the general and specific criteria to examine and present the medicinal plants with antiviral activities. Selected botanicals with their scientific names and classifications and their outcome (CC50 and IC50) are presented in the article. Antiviral activity of phytochemicals Against HSVs Todays, various compounds with antiviral activity are contributing in the most of the medicinal process for the cure of human viral infections (Singh et al. 2021; Mukhtar et al. 2008). Many studies have shown that naturally produced compounds with antiviral activity against two serotypes of HSV are polysaccharides (Jin et al. 2015), flavonoids (Flores et al. 2016), terpenes (Soares et al. 2007), Steroids (da Rosa Guimarães et al. 2013), saponins (Ogawa et al. 2021), tannins (Lin et al. 2011), Phenolic (Hassan et al. 2011), alkaloids (Chen et al 2015), lignans (Chen et al 2015), Miscellaneous (Treml et al. 2020), proanthocyanidin (Terlizzi et al. 2016), quinones (Caruso et al. 2020) and thiosulfinates (Rouf et al 2020). Several antiviral mechanisms of these phytochemicals have been identified, which most of them were verified against RNA and DNA viruses (Jang et al. 2021; Zrig 2022), such as herpes simplex virus type 1 and type 2 (DNA viruses) (Liu et al. 2019). These compounds inhibit the specific processes in the viral replication cycle (Hassan et al. 2018), and viral entry to the target cells (Rouf et al 2020), also they inhibit the viral gene and protein expression and suppress the NF- kB Activity (Hutterer et al. 2017) that can help to prevent the spread of viruses. Several studies have shown the antiviral mechanisms of these natural compounds against two HSV serotypes which are summarized in Table 1. Antiviral potential of Iranian Herbal Pharmacopoeia (IHP) The present review focuses on selected Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes. In this review, the articles were read and 34 herbs from 17 families were selected based on anti-herpetic activity and percentages of each families were calculated. According to families in IHP, Lamiaceae has the highest percentage (29.41 %) of plants with antiviral activity against two serotypes of HSV (Figure 1). Figure 1. The percentages of plant families against two serotypes of HSV. Gavanji – Anti-herpetic activity of Herbal Pharmacopoeia (IHP) 91 Table 1. Anti-herpetic activity of natural compounds. References Serotype Mechanisms Compositions Chemical groups No (Kutluay et al. 2008; Zalilawati et al. 2015; Zandi et al. 2010; Flores et al. 2016) HSV-1/HSV-2 Affecting the viral transactivator protein VP16 -mediated recruitment of RNA polymerase II (Pol II) to Immediate early (IE) gene promoters and Inhibits the HSV-1 replication, Inhibition of HSV-1 and HSV-2 replication and adsorption Curcumin Flavonoid 1 (Lyu et al. 2005) HSV-1/HSV-2 Inhibition of viral adsorption Galangin Flavonoid 2 (Lee et al 2017) HSV-1 Inhibiting expression of Glycoprotein D (gD) and Infected cell protein 0 (ICP0), and suppresses the TLR-3 Quercetin Flavonoid 3 (Li et al 2017) HSV-1 Blocking membrane fusion Houttuynoid Flavonoid 4 (de Oliveira et al. 2013; Isaacs et al. 2008; Subramanian and Geraghty 2007) HSV-1 Inhibition of viral adsorption, binding to HSV glycoproteins Epicatechin gallate Flavonoid 5 (Hung et al. 2015) Inhibition of NF-κB activation Isoquercitrin Flavonoid 6 (Hutterer et al. 2017; Chen et al 2015) HSV-1/HSV-2 Inhibition of viral replication and gene expression, reduction the NF-κB activation, and IκB-α degradation Harmine Alkaloid 7 (Hassan et al. 2011) HSV-1 Inhibition of HSV-1 DNA polymerase Psoromic acid Phenolic 8 (Li et al 2005; Hao 2019) HSV-1 Inhibition of viral replication Protocatechuyl aldehyde Phenolic 9 (Ma et al. 2016) HSV-1 Inhibition of HSV-1 adsorption and reduction of (IE) gene expression and viral DNA synthesis Kuwanon X Phenolic 10 (Lin et al. 2011) HSV-1 Blocking the interactions of virus and target cells Chebulagic acid (CHLA) Tannins 11 (Lin et al. 2011) HSV-1 Blocking the interactions of virus and target cells Punicalagin (PUG) Tannins 12 (Kesharwani et al. 2017) HSV-2 Inhibition of viral attachment to the target cells Chebulinic acid ( Tannins 13 (Kuo et al. 2002) HSV-1 Inhibition of viral replication Samarangenin Tannins 14 (Soares et al. 2007) HSV-1 Maybe target the HSV-1 replication Epitaondiol Diterpenes 15 (Álvarez et al. 2015) HSV-1 inhibition of viral gene expression (E)-2-(2,4-hexadiynyliden) - 1,6-dioxaspiro[4.5]dec-3-ene Miscellaneous 16 (Jin et al. 2015) HSV-1 Blocking the viral entry to the target cells by inactivating the viral particles, Inhibition of viral intracellular biosynthesis Eucheuma gelatinae polysaccharide (EGP) Polysaccharide 17 (Zhu et al. 2006) HSV-1 Inhibition of HSV-1 replication and viral entry to the target cells Sulfated polysaccharide Polysaccharide 18 (Bouhlal et al. 2011) HSV-1 Inhibition of virus adsorption Polysaccharide Boergeseniella thuyoides Polysaccharide 19 (Saha et al. 2012) HSV-1 Inhibition of viral attachment to the target cells by interaction with virus particles Alginic acids and Sulfated Polysaccharide 20 (Zheng and Lu 1990) HSV-1 Inhibition of viral replication Mangiferin Polyphenol 21 (Astani et al 2014; Chen et al 2017) HSV-1/HSV-2 Inhibition of viral replication and viral attachment to the target cells Rosmarinic acid Polyphenol 22 (Kuo et al 2006) HSV-1 Inhibiting expression of Infected-cell polypeptide 4 (ICP4) and Infected cell protein 0 (ICP0), and viral DNA synthesis Yatein Polyphenol 23 (Hassan et al. 2018) HSV-2 Inhibition of viral replication Geraniol Monoterpenoid 24 (Wiart et al. 2005) HSV-1 Inhibiting expression of Glycoprotein D Andrographolide Diterpenoid 25 (da Rosa Guimarães et al. 2013) HSV-1 Inhibition of viral attachment to the target cells Halistanol sulfate Steroids 26 (Rouf et al 2020) Inhibition of viral entry to the target cells Allicin Organosulfur 27 (Ikeda et al. 2005) HSV-1 Inhibition of viral replication Glycyrrhizic acid methyl ester Triterpenoid 28 (Tshilanda et al. 2020; Bag et al. 2012) HSV-1/HSV-2 Inhibition of viral replication [78,79] Ursolic acid Triterpenoid 29 92 Biology, Medicine, & Natural Product Chemistry 11 (2), 2022: 89-109 Apiaceae Apiaceae family which is called Umbelliferae, includes a large number of medicinal plants with various therapeutic properties has a significant role in pharmaceutical development (Amiri and Joharchi 2016; Ekiert 2000). Cuminum cyminum belonging to family Apiaceae is an aromatic plant that can be used as medicinal herbs to treat various diseases (Sowbhagya 2013; Mnif and Aifa 2015; Gavanji et al. 2015) and flavoring agents to improve the flavor of foods (Johri 2011). Researchers have reported that methanol extract of C. cyminum showed the antiviral effects against HSV- 1 (Table 2). Based on this study, the CC50, IC50 values were 0.45 and 0.18 mg/mL, respectively (Motamedifar et al. 2010). The molecular mechanism of C. cyminum against Herpes Simplex Virus has not yet been characterized, but the polyphenolic compounds in the extract may inhibit the HSV virus (Ani et al. 2006). Asteraceae The Asteraceae family, or sunflower family, including several thousand plants, has a long history of use in traditional herbal medicine (THM), for the treatment of diseases (Amiri and Joharchi 2016; Ekiert 2000). Artemisia aucheri belonging to family Asteraceae is an aromatic and endemic plant in Iran, which is widely used for treatment of various diseases (Gavanji et al. 2014). This plant has been reported for its antiviral activities (Kshirsagar and Rao 2021), and Karamoddini et al assessed the antiviral properties of Artemisia species against HSV-1 which Artemisia annua inhibited this serotype at different concentrations (Karamoddini et al. 2011). Another study indicated that Aqueous extract of A. aucheri had Anti-herpetic property on HSV-1 and reduced the expression of UL46 and US6 genes, and the IC50 of this extract, 24.7 μg/ml was determined (Zamanian et al. 2021). In the other study the anti- herpetic activity of aqueous extract of A. aucheri against HSV-1 was evaluated that viral infection significantly reduced at 50 and 75 μg/ml (Zamanian et al. 2021). Research in 2015 showed that phenolic compounds in Artemisia has antiherpetic activity which can cause some abnormalities in the function and structure of herpes simplex virus (Gavanji et al. 2015). Arctium lappa is another member of Asteraceae family which possesses various therapeutic potential to treat infectious diseases (Bai et al. 2016), In addition A. lappa exhibited, anti-inflammatory (Pirvu et al. 2017), anticancer (Leonard et al. 2006) and antiviral effects against two serotypes of HSV (Chan et al. 201; Dias et al. 2017). A study has been reported, that 400 mg/ml of hydroalcoholic extract of A. lappa inhibited the HSV-1 in in vitro condition (Dias et al. 2017) (Table 2). Echinacea purpurea a species of Asteraceae family is widely used for the treatment of diseases (Shemluck 1982), such as chest & lung conditions, colds, coughs, candidiasis and influenza (Hudson et al. 2005). Furthermore, E. purpurea exhibited significant antiviral activity against HSV-1 (Thompson 1998). Also, Garcia et al. assessed the antiherpetic activity of E. purpurea against HSV-1 which the IC50 and CC50 values, were determined to be 500 and 900 μg/ml, respectively (Farahani 2013). According to a study, chicoric acid exhibited antiviral properties against HSV-1 (Binns et al. 2002). Another in vivo study showed that E. purpurea polysaccharide (EP), antiviral effects on the development of HSV by promoting the immune response (Ghaemi et al. 2009). Another important species of Asteraceae family is Tanacetum parthenium which has been traditionally used to treat various diseases (Ghaemi et al. 2009). Benassi-Zanqueta et al. assessed the antiviral efficacy of chlorogenic acids and parthenolide which derived from T. parthenium against HSV-1 that results showed that chlorogenic acids was effective against HSV-1 (Benassi-Zanqueta et al. 2019). Base on this research, the hydroethanolic extract inhibited viral replication and the EC50 value was18.1 mg/ml. Avicenniaceae Avicenna marina is a member of Avicenniaceae family, which traditionally used for treatment of small pox, rheumatism and respiratory problems (Afzal et al. 2011; Namazi et al 2013). And has strong antiviral activity against HSV-1 (Chiang et al. 2003; Namazi et al, 2013; Behbahani et al. 2013). A study showed that glycerin extract of A. marina, inhibited the HSV-1 and the IC50 values before and after virus attachment and CC50 were determined to be 87.1, 41.9 and 5750.96 μg/ml, respectively (Zandi et al. 2009). Based on the previous studies, A. marina, contains many phytocompounds with antiviral potentials to inhibit herpes simplex viruses (HSV). Several studies have shown that flavonoids in the A. marina extract plays a crucial role in antiviral activities against HSV-1 (Chiang et al. 2003; Namazi et al, 2013; Behbahani et al. 2013). (Table 2). Gavanji – Anti-herpetic activity of Herbal Pharmacopoeia (IHP) 93 Table 2. Antiviral mechanism of Iranian Herbal Pharmacopoeia (IHP) against herpes simplex viruses (HSV-1 and -2) No Plant name Family Type of study (in vitro or in vivo) Type of virus Compounds and Mechanisms References 1 Aloe vera Xanthorrhoeacea e In vitro HSV-1/ HSV-2 Aloe-emodin inhibits the replication of viral enveloped (Lin et al. 2008; Zandi et al. 2007; Rezazadeh et al. 2016) 2 Artemisia aucheri Asteraceae In vitro HSV-1 Artemisinin inhibits the central regulatory processes and blocks the metabolic requirements of replication, reduces the UL46 and US6 genes (Kshirsagar and Rao 2021; Karamoddini et al. 2011; Zamanian et al. 2021a; Zamanian et al. 2021b). 3 Arctium lappa Asteraceae In vitro HSV-1 Arctigenin inhibits the viral replication, Phenolic constituents such as caffeic acid and chlorogenic acid inhibit the viral multiplication (Dias et al. 2017; Wang et al. 2019; Yang et al 2005; Lal et al 2020; Chiang et al. 2002; Chan et al. 2011) 4 Avicenna marina Avicenniaceae In vitro HSV-1 Luteolin inhibits the viral replication (Chiang et al. 2003; Namazi et al. 2013) 5 Camellia sinensis Theaceae In vitro HSV-1 Epicatechin gallate Inhibits the viral adsorption, binding to HSV glycoproteins (de Oliveira et al. 2013; Isaacs et al. 2008; Subramanian and Geraghty 2007) 6 Cuminum cyminum Apiaceae. In vitro HSV-1 EHP [1-(2-Ethyl, 6-Heptyl) Phenol] effects on the percentage of plaque (Mohamadein et al. 2015; Motamedifar et al. 2010) 7 Curcuma longa Zingiberaceae In vitro HSV-1/ HSV-2 Affecting the viral transactivator protein VP16 -mediated recruitment of RNA polymerase II (Pol II) to Immediate early (IE) gene promoters and Inhibits the HSV-1 replication, Inhibition of HSV-1 and HSV-2 replication and adsorption (Hutterer et al. 2017; Kutluay et al. 2008; Zalilawati et al. 2015; Flores et al. 2016) 8 Echium amoenum Boraginaceae In vitro HSV-1 Rosmarinic acid inhibits the viral attachment to host cells (Flores et al. 2016; Chen et al. 2017) 9 Echinacea purpurea Asteraceae In vitro/In vivo HSV-1 Cichoric acid interact and inhibit the virus activities (Binns et al. 2002; Pluymers et al. 2000; Burlou-Nagy et al. 2022; Zhang et al. 2014) 10 Euphorbia spinidens Euphorbiaceae In vitro HSV-1 Betulin and (3β,23E)-cycloarta-23-ene-3,25-diol, the extract Inhibits the viral replication and adsorption (Shamsabadipour et al. 2013; Karimi et al. 2016) 11 Eucalyptus caesia Myrtaceae In vitro HSV-1 Unknown (Schnitzler et al. 2001; Brezáni et al. 2018; Mieres- Castro et al. 2021) 12 Eucalyptus globulus Myrtaceae In vitro HSV-1 Grandinol, sideroxylin, and tereticornate inhibit the viral replication (Schnitzler et al. 2001; Brezáni et al. 2018; Mieres- Castro et al. 2021; Ma and Yao 2020; Mohan et al. 2020) 13 Glycyrrhiza glabra Leguminosae In vitro HSV-1 glycyrrhizic acid (glycyrrhizin) inhibits the viral replication, suppress the growth (Ghannad et al. 2014; Fukuchi et al. 2016; van Rossum et al. 1998; Cohen 2005; Huan et al. 2021) 14 Hypericum perforatum Hypericaceae In vitro/In vivo HSV-1/ HSV-2 Hypericin Inhibits the viral adsorption (Huan et al. 2021; Weber et al. 1994; Mohamed et al. 2022; Fritz et al. 2007; Westh et al. 2004; Béjaoui et al. 2017) 15 Hyssopus officinalis Lamiaceae In vitro HSV-1/ HSV-2 Unknown (Akram et al. 2018; Behbahani 2009; Schnitzler et al. 2019) 16 Melissa officinalis Lamiaceae In vitro HSV-1/ HSV-2 Rosmarinic acid inhibits the viral attachment to host cells (Astani et al 2014a; Astani et al. 2012b; Mazzanti et al. 2008) 17 Mentha piperita Lamiaceae In vitro HSV-1/ HSV-2 Piperitenone oxide (PEO) and Menthol Inhibit the viral replication and adsorption (Wolbling et al. 1994; Koytchev et al. 1999; Civitelli et al. 2014; Herrmann et al. 1967) 18 Myrtus communis Myrtaceae In vitro HSV-1 Unknown (Moradi et al. 2011; Alipour et al. 2014; Isaacs et al. 2008) 94 Biology, Medicine, & Natural Product Chemistry 11 (2), 2022: 89-109 No Plant name Family Type of study (in vitro or in vivo) Type of virus Compounds and Mechanisms References 19 Olea europaea Oleaceae In vitro HSV-1 Phenolic compounds such as caffeic acid inhibits the viral multiplication (Motamedifar et al. 2015; Ben-Amor et al. 2021; Ikeda et al. 2011) 20 Ocimum basilicum Lamiaceae In vitro HSV-1/ HSV-2 Ursolic acid and Apigenin Inhibit the viral replication (Chiang et al. 2005; Bag et al. 2012; Lin et al. 2008) 21 Plantago major Plantaginaceae In vitro HSV-1/ HSV-2 Caffeic acid inhibits the viral multiplication (Chiang et al. 2002; Ben-Amor et al. 2021; Ikeda et al. 2011) 22 Quercus Persica Fagaceae In vitro HSV-1 Tannic acid inhibits viral replication (Chiang et al. 2005; Wu et al. 2022; Karimi et al. 2013; Kaczmarek 2020; Nance and Shearer 2013) 23 Ricinus communis Euphorbiaceae In vitro HSV-1 The alkaloid and phenolic compound have antiherpetic activity (Elkousy et al. 2021; Abdul et al. 1996) 24 Rheum palmatum Polygonaceae In vitro/In vivo HSV-1 Unknown (Abdul et al. 1996; Kurokawa et al. 1993; Chang et al. 2014; Shen et al. 2019) 25 Rosmarinus officinalis Lamiaceae In vitro HSV-1/ HSV-2 Rosmarinic acid Inhibit of viral replication and viral attachment to the target cells (Al-Megrin et al. 2020; Mancini et al. 2009; Hitl et al. 2021; Chen et al. 2017; Astani et al 2014) 26 Salvia officinalis Lamiaceae In vitro/In vivo HSV-1/ HSV-2 Thujone, β-caryophyllene linalyl acetate, alpha terpinyl acetate, and germacrene D have anti-herpetic activity (Shen et al. 2019; Al-Megrin et al. 2020; Mancini et al. 2009; Hitl et al. 2009; Schnitzler et al. 2008; Rajbhandari et al. 2001; Santoyo et al. 2014; Ezema et al. 2022) 27 Satureja hotensis Lamiaceae In vitro HSV-1 Unknown (Hamidpour et al. 2014; Khalil et al. 2020) 28 Securigera Securidaca Leguminosae In vitro HSV-1 Kaempferol and kaempferol-7-O-glucoside inhibit the HSV infection but the mechanism is unknown (Behbahani et al. 2014; Behbahani et al. 2013) 29 Solanum paniculatum Solanaceae In vitro HSV-1 Unknown (Valadares et al. 2009; Kaunda and Zhang 2019) 30 Tanacetum parthenium Asteraceae In vitro/In vivo HSV-1 Parthenolide did not directly act against HSV, and it can able to handle the defense mechanisms in host cells against viral particles (Benassi-Zanqueta et al. 2019; Benassi-Zanqueta et al. 2018) 31 Thymus vulgaris Lamiaceae In vitro HSV-1/ HSV-2 Thymol reduces the viral transmission (Gavanji et al. 2015; Catella et al. 2021; Nolkemper et al. 2006; Sharifi-Rad et al. 2017; Lai et al. 2012) 32 Thymus kotschyanus Lamiaceae In vitro HSV-1/ HSV-2 Borneol, and isoborneol that inhibits the viral replication (Farahani 2017; Yang et al. 2020) 33 Zataria multiflora Lamiaceae In vitro HSV-1 Rosmarinic acid inhibits the viral attachment to host cells (Arabzadeh et al. 2020; Ben-Shabat et al. 2020; Mardani et al.. 2012; Astani et al 2014; Chen et al 2017) 34 Zingiber officinale Zingiberaceae In vitro/In vivo HSV-1 Unknown (Schnitzler et al. 2012; Camero et al. 2019; Koch et al. 2008; Hayati et al. 2021) Gavanji – Anti-herpetic activity of Herbal Pharmacopoeia (IHP) 95 Boraginaceae Echium amoenum, commonly known as borage, belongs to the family Boraginaceae (Zannou et al. 2021), which has a long history in Iranian traditional medicine (ITM) for treatment of influenza and infectious diseases (Ranjbar et al. 2006). This plant has antiviral properties against HSV-1, and the IC50 and CC50 values were determined to be 500 and 1000 μg/ml, respectively, also the results of this research showed that virus replication was inhibited at the lower concentration than 400 μg/ml (Abolhassani 2010; Farahani 2013). Euphorbiaceae Euphorbia spinidens, a member of Euphorbiaceae family, is traditionally used as antiasthmatic, relieving stomachache, laxative and emetic (Ghanadian et al. 2016). This plant contains several types of bioactive compounds which exhibited significant antimicrobial activities (Li et al. 2009). Furthermore, a research demonstrated that hexan fraction of E. spinidens showed the inhibitory activity against HSV-1, and the IC50 value of 9.92±0.072 mg/ml was determined (Li et al. 2009). Another study stated that the methanolic extract of E. spinidens was active against HSV-1 with EC50 and SI values, of 0.34mg/ml and 14.9 respectively, and this Research showed that E. spinidens can inhibit the viral replication and adsorption (Karimi et al. 2016). Ricinus communis is another member of Euphorbiaceae family (Abdul et al. 2018), which contains many phytochemicals and can be used to treat a wide range of diseases (Scarpa and Guerci 1982; Ohishi et al. 2014). A study showed that ethanolic extracts of R. communis has potent antiviral activity against HSV-1 and inhibited this virus at concentration of 0.1 mg/ml (Abdul. et al. 1996). Fagaceae Quercus Persica, commonly known as oak, belonging to the family Fagaceae, has been used in Iranian traditional medicine(ITM) for the treatment of various disease (Karimian et al. 2020). A study demonstrated that hydroalchoholic extract of Q. Persica has anti-HSV activity. In this research the authors conclude that Q. Persica extract has inhibited the HSV‑1, and the IC50 values, before and after attachment to BHK, were determined to be 1.02 and 0.257 μg/ml, respectively (Karimi et al. 2013). Another study by Karimi et al. stated that Quercus brantii extract showed the inhibitory activity against HSV-1, and the IC50 and SI values of 4.3 μg/ml and 48.4 were determined, respectively (Karimi et al. 2017). Hypericaceae Hypericum perforatum, a member of Hypericaceae family, is a medicinal plant which has been widely used as antidepressants, anti-cancer and psychotic disorders (Klemow et al. 2011). A number of studies demonstrated that H. perforatum, has strong antiviral activity against numerous viruses, including radiation- leukaemia virus (RadLV), friend virus (FV), human immunodeficiency virus type 1 (HIV-1) and HSV-1 (Weber et al.1994). Also a scientific research showed that the complex of H. perforatum and lysine hydrochloride, remarkably inhibited the HSV‑1 and the IC50 value was from 6.8 to 9.7 mg/ml (HU et al. 2004). Lamiaceae Hyssopus officinalis belongs to the family Lamiaceae, which is traditionally used for treatment of chest & lung conditions, coughs, colds and Infectious diseases (Vlase et al. 2014), also several studies demonstrated that H. officinalis extract has antifungal and antiviral activity (Fathiazad et al. 2011). A study by Behbahani, showed that methanolic extract of H. officinalis significantly inhibited two HSV serotypes, which the EC50 and CC50 values, against HSV‑1, were determined to be 4.1±0.40 and 960 μg/ml, respectively, and for HSV‑2, the EC50 and CC50 values were > 5.0 and 100 μg/ml, respectively (Behbahani 2009). Another study stated that essential oil of H. officinalis was active against HSV-1, and EC50 and CC50 values, were determined to be 0.0001±0.00001 and 0.0075±0.002 % respectively (Schnitzler et al. 2007). Another important species of Lamiaceae family is Melissa officinalis, which is a well-known and it has been used in traditional medicine for treatment of various diseases (Miraj et al. 2017). Furthermore, a research showed that M. officinalis has inhibitory activity against HSV‑1 and inhibited the viral attachment to the host cells, and the IC50 and SI values of 0.4 μg/ml and 350 were determined, respectively (Astani et al 2014). Mentha piperita is antother important species of Lamiaceae family which has therapeutic potential to treat different diseases (Zaker et al. 2014; Alves et al. 2012). Schuhmacher et al., demonstrated that the essential oil of M. piperita, can able to inhibit the herpes simplex virus type 1, and reduce the plaque formation by up to 82% for HSV-1 (Schuhmacher et al. 2003). Another research stated that the M. piperita extract was effective against HSV-1 and inhibited the viral replication cycle, which ED50 and TI values were determined to be 62.70 mg/ml and 1.79, respectively (Omidian et al. 2014). Several studies exhibited that many species of Lamiaceae family has potential to inhibit the two HSV serotypes. Ocimum basilicum or great basil, a traditional medicinal plant, belongs to the family Lamiaceae which is widely used for treatment of different diseases including, headaches, diabetes, nerve pain and anxiety (Bora et al. 2011). A study revealed that water and ethanolic extracts of O. basilicum have inhibited two HSV serotypes, the result of this research showed that the EC50 and SI values of water extracts against HSV-1, were determined to be 90.9 mg/ml and 16.2, also for HSV-2 were 51.4 mg/ml and 28.6 respectively. Ethanolic extract showed inhibitory activity against HSV-1, and EC50 and SI values of 108.3μg/ml and 6.3 were determined, respectively (Chiang et al. 2005). Another important 96 Biology, Medicine, & Natural Product Chemistry 11 (2), 2022: 89-109 species of Lamiaceae family is Rosmarinus officinalis, which is widely used in treatment of rheumatic pain, headache, hysteria, stomachache, depression and infectious diseases (Ghasemzadeh Rahbardar et al. 2020). A study reported that extract of R. officinalis, exhibited potential antiviral activity against HSV-1 and HSV-2, which this extract at the concentration of 30 μg/ml inhibited the 55% of HSV-1 and at 40μg/ml inhibited the 65% of HSV-2 plaques and extract of R. officinalis showed the significant inhibitory effect at the 50 μg/ml concentration two HSV serotypes (Al-Megrin et al. 2020). Another important species of Lamiaceae family is Salvia officinalis, that is used in traditional medicine to treat different kinds of diseases, such as rheumatism, diarrhea, ulcers, inflammation and paralysis. This plant contains several types of phytochemicals which exhibited significant antibacterial, antifungal and antiviral activities (Ghorbani and Esmaeilizadeh 2017). A study demonstrated that two diterpenoids compounds (safficinolide and sage one) which is isolated od aerial parts, have antiviral activity (Smidling et al. 2008). A number of research studies demonstrated that S. officinalis has antiviral activity against two serotypes of HSV. The extract of S. officinalis was used in the study, against HSV-1, which the IC50 value of this extract, 199.0 μg/ml was determined (Smidling et al. 2008), and in another studies IC50 value was 1.41–1.88 μg/ml and Inhibited the plaque formation (Santoyo et al. 2014). Schnitzler et al. studied the antiviral activity of S. officinalis extract against two serotypes of HSV which IC50 values for HSV-1 and 2 were 0.18 and 0.04 μg/ml respectively (Schnitzler et al. 2008). Satureja hotensis is another important species of Lamiaceae family which can use in treatment of many ailments and diseases. In this plant, various types of phytochemicals such as flavonoids steroids, triterpenoids, and and sesquiterpenoids, have been identified (Gursoy et al. 2009; Golestannejad et al. 2015), which are used in pharmaceutical industries (Tepe and Cilkiz 2016). A study showed that this plant has potential antiviral activity against HSV-1, which IC50 and CC50 values were determined to be 0.008% and 0.245%, respectively (Gavanji et al. 2015). One of the important species of Lamiaceae family is Thymus vulgaris commonly known as thyme and is the rich sources of phytochemicals which are widely used for the treatment of inflammation, cancers, and infectious diseases (Gavanji and Larki 2017). A study demonstrated that the essential oil of T. vulgaris was effective against two serotypes of HSV and reduce the viral infectivity, which IC50 for 1,8-cineole, 1200 μg/ml was determined (Gavanji and Larki 2017). Furthermore, a study revealed that aqueous extract of T. vulgaris has inhibitory effects against two serotypes of HSV, which IC50 and SI values for HSV-1, were 0.065 mg/ml and 954, also for HSV-2, 0.077 mg/ml and 805 were determined, respectively (Nolkemper et al. 2006). Another member of Lamiaceae family is Thymus kotschyanus which has anti-viral activity and inhibited HSV-1 at the higher concentration of 400 μg/ml (Farahani 2017). Based on a study, T. kotschyanus contains many bioactive compounds such as Borneol, has impressive antiviral potentials to inhibit herpes simplex viruses (Armaka et al. 1999) (Table 2). Zataria multiflora is one of the most important species of Lamiaceae family which is used to relieve some of illnesses such as fever, bone pain, flatulence, cough, cold and infectious diseases (Ghorani et al. 2022; Dadashi et al. 2016). A research study has been documented, reporting that methanolic extract of Z. multiflora at the 1000 mg/ml concentration, remarkably reduce the plaque formation of HSV‑1 (Arabzadeh et al. 2013). Moreover, essential oil of Z. multiflora exhibited antiviral potential against HSV‑1, in which IC50 and SI values were determined to be 0.0059% and 11.7, respectively (Mardani et al. 2012). Another study revealed that essential oil of Z. multiflora contains Rosmarinic acid which is an antiviral compound and inhibited the viral attachment to host cells. this study demonstrated that Z. multiflora oil, has strong antiviral activity which IC50 and CC50 values were determined to be 0.003% and 0.166%, respectively (Gavanji et al. 2015). Zingiber officinale or Ginger is another important species of Lamiaceae family which is widely used for treatment different diseases in traditional medicine (Grzanna et al. 2005). Z. officinale has broad-spectrum antiviral potential on Human Respiratory Syncytial Virus (HRSV) (Chang et al. 2013), hepatitis C virus (HCV), influenza A (H1N1) (Sahoo et al. 2016), and two serotypes of HSV [123,180]. The study has demonstrated that Z. officinale inhibited the HSV-2 with IC50 and SI values of 0.0001% and 40 respectively (Allahverdiyev et al. 2013). Another study by Koch et al stated that Z. officinale possess antiviral activity, and the IC50 value of 0.001% was determined (Koch et al. 2008) (Table 2). Leguminosae Securigera Securidaca, a species of Leguminosae family, is widely used as herbal for the treatment of several diseases in Iranian traditional medicine (ITM). S. Securidaca is a rich source of flavonoids having significant antibacterial, antifungal and antiviral activities (Raesi Vanani et al. 2019). Also the result of a research study showed that, two major compounds, including Kaempferol and kaempferol-7-O-glucoside which is isolated from S. Securidaca, can inhibit the HSV infection (Behbahani et al. 2013). Another study showed that methanolic extract of S. Securidaca has inhibited the HSV‑2 with IC50 and CC50 values of 1.6 and 130 μg/ml, respectively (Sayedipour et al. 2012). Furthermore, S. Securidaca exhibited significant antiviral activity against HSV-1 which IC50 and CC50 Gavanji – Anti-herpetic activity of Herbal Pharmacopoeia (IHP) 97 values of 2 and 500 μg/ml, were determined, respectively (Behbahani et al. 2013). Glycyrrhiza glabra is another medicinal plant from Leguminosae family which has been reported for healing gastroesophageal reflux disease, liver diseases, tuberculosis and infectious diseases (Wahab et al. 2021). Numerous antiviral phytochemicals, such as glycyrrhetinic acid, and glycyrrhizin were isolated from G. glabra which have antiviral activity against HSV-1 (Ming and Yin 2013; Huan et al. 2021). Based on the results of a research, G. glabra extract has inhibited the HSV‑1 with IC50 and CC50 values of 500 and 800 μg/ml, respectively (Monavari et al. 2008). Another study by Fukuchi et al. stated that water extract of G. glabra with EC50 and SI values of 650 to 740 mg/ml, and 2.0 to >4.6, respectively, showed a strong inhibitory activity against HSV-1, compared to alkaline extracts of G. glabra with EC50 and SI values of 600 to >3000 mg/ml, and to 3.2, respectively (Fukuchi et al. 2016). Myrtaceae Eucalyptus caesia and Eucalyptus globulus are the two most common species of Myrtaceae family which have Numerous phytopharmacological potential to treat different kinds of diseases, such as asthma, pulmonary, cold, bronchitis, and infectious diseases (Mieres- Castroet al. 2021). Both of these species exhibited antiviral properties against HSV-1 and HSV-2 (Mieres- Castroet al. 2021). A study demonstrated that essential oil of E. globulus inhibited two HSV serotypes which IC50 and SI values for HSV-1, were determined to be 0.009% 3.3, respectively and for HSV-2, were 0.008% and 3.75, respectively (Schnitzler et al. 2001). Furthermore, a research demonstrated that 1,8-cineole reduced the HSV infection under in vivo condition (Behbahani et al. 2013). Another study Researchers compared the Effect of E. globulus oil and individual monoterpenes against HSV-1, which result of this study showed that E. globulus 1,8-cineole, α-pinene, γ- Terpinene, p-cymene, α-Terpineol and terpinen-4-ol, have antiviral activity against HSV-1 with IC50 of 55, 1.20, 4.5, 7.0, 16.0, 22.0, and 60.0 μg/ml, respectively (Astani et al. 2010). Another study revealed that essential oil of E. caesia inhibited two HSV-1 which IC50 and CC50 values, were determined to be 0.004% and 0.287%, respectively (Gavanji et al. 2015). Myrtus communis is another important member of Myrtaceae family, which has been used in traditional medicine to treat many diseases such as hemorrhoid, recurrent aphthous stomatitis, diarrhea, and infectious diseases (Mahboubi 2016; Alipour et al. 2016). Based on a study, the hydroalcoholic extract of M. communis, has impressive antiviral potentials to inhibit HSV-1, which IC50 and CC50 values, were determined to be 3100 and 4960 μg/ml, respectively (Moradi et al. 2011). This herb showed anti-herpetic activity, under clinical trial condition, which the result of this study demonstrated that myrtle oil, reduced the signs and symptoms of disease in the treated group, in comparison to other control groups (Zolfaghari et al. 1997). Oleaceae Olea europaea, a member of Oleaceae family, can be used to treat a wide range of diseases in traditional medicine, such as diarrhea, hemorrhoids, infectious diseases, inflammation and rheumatism (Alipour et al. 2016). O. europaea has antiviral activities against many types of viruses, including Canine parvovirus (CPV), hepatitis virus, bovine rhinovirus (BRAV), herpes virus (HSV) and Feline leukemia virus (FeLV) (Ben-Amor et al. 2021). A study demonstrated that hydroalcoholic extract of O. europaea var. sylvestris exhibited anti- HSV-1 activity that EC50 and CC50 values, for pre- infection assay, were determined to be 0.12 and 0.2 mg/ml, respectively and for post-infection assay were 0.15 and 0.2 mg/ml, respectively (Ben-Amor et al. 2021).Another study by Motamedifar et al. stated that hydroalcoholic extract of O. europaea with IC50 and CC50 values of 660 and 1750 μg/ml, respectively, showed a strong inhibitory activity against HSV-1 (Motamedifar et al. 2015). Plantaginaceae Plantago major belongs to the family Plantaginaceae, which is commonly known as greater plantain, and it has been traditionally used to treat many diseases such as fever, constipation and wounds and bleeding. Furthermore, P. major has been reported to contain caffeic acid, that demonstrated the strongest antiviral activity against two serotypes of HSV (Najafian et al. 2018). A study showed that aqueous extract of P. major has weak antiviral activity against HSV-1 and HSV-2, in extracts, pure compounds such has Caffeic acid demonstrated the strongest antiviral activity against HSV-1. Moreover, this study stated that aqueous extract of P. major inhibited HSV-2 with EC50 and SI values, of 843 mg/ml and 2.2, respectively and Caffeic acid isolated from P. major exhibited the antiviral activity against HSV-1 with EC50 and SI values, of 15.3 μg/ml and 671, and HSV-2 EC50 and SI values, were determined to be 87.3 μg/ml and 118, respectively (Chiang et al. 2002; Chiang 2003). Polygonaceae Rheum palmatum a flowering plant of Polygonaceae family, which can be used to treat a wide range of diseases such as gasteroenteritic, herpes and kidney disease (Chang et al. 2014). R. palmatum contains several types of natural compounds such as emodin, chrysophanol and aloe-emodin which exhibited significant anti-viral activities (Li et al. 2007). A study has been documented that Aloe-emodin isolated from R. palmatum has antiviral activity against HSV (Types 1 and 2), influenza virus (Sydiskis et al. 1991), human cytomegalovirus (HCMV) (Barnard et al. 1992), and polio viruses (Semple et al. 2001), also emodin and 98 Biology, Medicine, & Natural Product Chemistry 11 (2), 2022: 89-109 chrysophanol have antiviral property against hepatitis B virus (HBV) (Shuangsuo et al. 2006), hepatitis C virus (HCV) and human immunodeficiency viruses (HIV) (Kubin et al. 2005). A study demonstrated that R. tanguticum nanoparticles suppressed the HSV-1, which EC50 and CC50 values, were determined to be 194.1 and 415.3 μg/ml, respectively (Shen et al. 2019). Solanaceae Solanum paniculatum or jurubeba, a member of Solanaceae family, which is widely used to treat several diseases including hypertension, anemia, inflammation and tuberculosis (Tenório et al. 2016). A research study by Valadares et al., showed that ethanolic extract of S. paniculatum exhibited antiviral property against HSV-1, which EC50 and SI values, were determined to be 298 mg/ml and 1.4, respectively (Valadares et al. 2009). Theaceae Camellia sinensis or green tea, is a medicinal plant of Theaceae family which is used as the most consumed and favorable drink in the world. C. sinensis has many medicinal properties (Singhal et al. 2017). Based on a study, C. sinensis contains many bioactive compounds that has impressive antiviral potentials to inhibit herpes simplex viruses tape 1, with IC50 and SI values, of 20 mg/ml and 50, respectively (Farahani et al. 2014). Another study, stated that aqueous extract of C. sinensis exhibited the antiviral activity against HSV-1, which IC50, CC50 and SI values, were determined to be 50, 1000 μg/ml and 20, respectively (Farahani et al. 2013) Another scientific research reported that methanolic extracts of C. sinensis completely inhibited two HSV serotypes at 12 μg/mL concertation (Deepika et al. 2014). Xanthorrhoeaceae Aloe vera, commonly known as Aloe barbadensis, is a member of Xanthorrhoeaceae family which has been traditionally used to treat various diseases such as abdominal pains, malaria, arthritis, fever, and skin diseases (Adams et al. 2014). A. vera produces a wide range of phytochemicals, such as emodin and Aloe- emodin which exhibit potential strong antiviral activity against two serotypes of HSV, immunodeficiency virus (HIV), and influenza virus (brahimi et al. 2021). Another an anthraquinone compound isolated from A. vera, is Aloe-emodin which inhibits the viral replication of HSV serotypes and the IC50 value, of 1.5–6.0 μg/mL was determined (Sydiskis et al. 1991). A study demonstrated that topical A. vera gel at 0.2 to 5% concentrations can inhibit HSV-I growth (Rezazadeh et al. 2016). Another study by Ebrahimi et al. revealed that A. vera extract inhibited the HSV-1 with IC50, CC50 and SI values, were determined to be 10000 ± 55, 20000 ± 94 μg/ml, and 2.0 respectively (brahimi et al. 2021). Also the result of a study showed that hot glycerine extract of Aloe vera can able to inhibit the HSV-2, which the IC50, CC50 and SI values, were determined to be 428, 3238 μg/ml and 7.56, respectively (Zandi et al. 2007). Zingiberaceae Curcuma longa belongs to the family Zingiberaceae, which is used in Iranian traditional medicine(ITM) for healing rheumatism, anorexia, wounds, cough and respiratory diseases (Trujillo et al. 2013). A research study showed that, 2 mg/mL of C. longa extract reduced the plaque formation of HSV-1 (Fani et al. 2015). Furthermore, a research demonstrated that C. longa has inhibitory effect against HSV-1, and the IC50, CC50 and SI values were 33.0, 484.2 μg/ml and 14.6, respectively (Lyu et al. 2005). Another study revealed that C. longa extract contains polyphenolic compounds such as Curcumin which affects the viral transactivator protein VP16 -mediated recruitment of RNA polymerase II (Pol II) to Immediate early (IE) gene promoters and Inhibits the HSV-1 replication. This study stated that curcumin has significant has antiherpetic activity and inhibited HSV-2 with ED50 value, of 0.32 mg/ml (Kutluay et al. 2008). Zingiber officinale or ginger is another antiviral species of Zingiberaceae family which exhibited antiviral activity against numerous viruses (Wang et al. 2020). Based on a study, the essential oil of Z. officinale, has impressive antiviral potentials to inhibit HSV-1, whit IC50 value, of 0.001% (Koch et al. 2008). CONCLUSIONS Since time immemorial, a human being has sought medications to relieve pain and remedy for various diseases. Weighty evidence demonstrates the use of medicinal plants for therapeutic purposes and numerous research studies have been done to investigate the novel antiviral agents. In this review, all reported data of herbal medicines (34 herbs from 17 families) with antiviral activity against HSV through Iranian Herbal Pharmacopoeia (IHP) were collected. In some cases, screening test of medicinal plants for anti-herpetic activity was done under in vitro condition and only a few of them were done under clinical trial condition. Additionally, in many research studies, bioactive phytochemicals and mechanisms of actions, were not identified. Results of this review suggest that further research to identify and purify the bioactive compounds to determine the molecular mechanisms of action are needed. Acknowledgements: I would like to thank Dr. Forough Mortezaienejad for guidance on this project. Competing Interests: The authors declare that there are no competing interests. Gavanji – Anti-herpetic activity of Herbal Pharmacopoeia (IHP) 99 REFERENCES Abdul, A. M., Mackeen, M. M., EI-Sharkawy, S. H., Abdul, H., Junainah, N. H., Ismail, N. H., Ahmad, F., & Lajis, M. (1996). Antiviral and cytotoxic activities of some plants used in Malaysian indigenous medicine. Pertanika Journal of Tropical Agricultural Science,19(2),129-136. http://psasir.upm.edu.my/id/eprint/3541/ Abdul, W. M., Hajrah, N. H., Sabir, J. S., Al-Garni, S. M., Sabir, M. J., Kabli, S.A., Saini, K. S., & Bora, R. S. (2018). Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment. 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