id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
biomedich-934	Nuari, Afidah Fajar; Jayanti, Gatra Ervi; Ramadhan, Majida	In silico and Histochemical Analysis of Soursop Leaves (Annona muricata) Against Alpha Estrogen Receptor	2025	14	.pdf	application/pdf	7073	350	45	This study aims to identify active compounds in soursop leaves that have the potential to inhibit breast cancer cell growth through in silico analysis using molecular docking of the ERα receptor using KNApSAck, PASS Online, PubChem, PDB ID, PyRx, and Discovery Studio software and Histochemical analysis was performed using fresh soursop leaves by making an incision on the lower part of the leaf and adding reagents AlCl, FeCl, Na2CO, CuSO4, glycerin, Wagner reagent, immersion oil, and ethanol, then observed microscopically. Based on the results of the prediction stage of the interaction of active compounds in Soursop leaves with the Alpha Estrogen Receptor analysis molecule (Table 3), it was found that the specific soursop leaf compound that had the highest binding affinity and the strongest bond was the Cis-Solamin compound of -9.3 kcal/mol, Cis-Solamin has an RMSD value below 3 Å so that the data can be said to be valid, Cis-Solamin has a Lower bond RMSD of 1.673 Å and an Upper bond RMSD of 2.590 Å. While the native ligand or control compound, namely OHT600, has a binding affinity value of -7.6 with a Lower bond RMSD of 0.681 Å and an Upper bond RMSD of 1.528 Å. Based on molecular docking, it was found that the Cis-Solamin compound has a higher binding affinity value than the OHT600 compound, 1066 Biology, Medicine, & Natural Product Chemistry 14 (2), 2025: 1055-1068 which was used as a control in this study.	cache/biomedich-934.pdf	txt/biomedich-934.txt