id	sid	tid	token	lemma	pos
biomedich-1021	1	1	biology	biology	NOUN
biomedich-1021	1	2	,	,	PUNCT
biomedich-1021	1	3	medicine	medicine	NOUN
biomedich-1021	1	4	,	,	PUNCT
biomedich-1021	1	5	&	&	CCONJ
biomedich-1021	1	6	natural	natural	ADJ
biomedich-1021	1	7	product	product	NOUN
biomedich-1021	1	8	chemistry	chemistry	NOUN
biomedich-1021	1	9	issn	issn	VERB
biomedich-1021	1	10	2089	2089	NUM
biomedich-1021	1	11	-	-	SYM
biomedich-1021	1	12	6514	6514	NUM
biomedich-1021	1	13	(	(	PUNCT
biomedich-1021	1	14	paper	paper	NOUN
biomedich-1021	1	15	)	)	PUNCT
biomedich-1021	1	16	volume	volume	NOUN
biomedich-1021	1	17	14	14	NUM
biomedich-1021	1	18	,	,	PUNCT
biomedich-1021	1	19	number	number	NOUN
biomedich-1021	1	20	2	2	NUM
biomedich-1021	1	21	,	,	PUNCT
biomedich-1021	1	22	october	october	PROPN
biomedich-1021	1	23	2025	2025	NUM
biomedich-1021	1	24	|	|	ADV
biomedich-1021	1	25	pages	page	NOUN
biomedich-1021	1	26	:	:	PUNCT
biomedich-1021	1	27	1265	1265	NUM
biomedich-1021	1	28	-	-	SYM
biomedich-1021	1	29	1271	1271	NUM
biomedich-1021	1	30	|	|	ADV
biomedich-1021	1	31	doi	doi	NOUN
biomedich-1021	1	32	:	:	PUNCT
biomedich-1021	1	33	10.14421	10.14421	NUM
biomedich-1021	1	34	/	/	SYM
biomedich-1021	1	35	biomedich.2025.142.1265	biomedich.2025.142.1265	NOUN
biomedich-1021	1	36	-	-	PUNCT
biomedich-1021	1	37	1271	1271	NUM
biomedich-1021	1	38	issn	issn	PROPN
biomedich-1021	1	39	2540	2540	NUM
biomedich-1021	1	40	-	-	SYM
biomedich-1021	1	41	9328	9328	NUM
biomedich-1021	1	42	(	(	PUNCT
biomedich-1021	1	43	online	online	ADV
biomedich-1021	1	44	)	)	PUNCT
biomedich-1021	1	45	in	in	ADP
biomedich-1021	1	46	silico	silico	NOUN
biomedich-1021	1	47	exploration	exploration	NOUN
biomedich-1021	1	48	of	of	ADP
biomedich-1021	1	49	bioactive	bioactive	ADJ
biomedich-1021	1	50	compounds	compound	NOUN
biomedich-1021	1	51	from	from	ADP
biomedich-1021	1	52	dracaena	dracaena	ADJ
biomedich-1021	1	53	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	1	54	as	as	ADP
biomedich-1021	1	55	potential	potential	ADJ
biomedich-1021	1	56	inhibitors	inhibitor	NOUN
biomedich-1021	1	57	of	of	ADP
biomedich-1021	1	58	streptococcus	streptococcus	NOUN
biomedich-1021	1	59	pyogenes	pyogene	NOUN
biomedich-1021	1	60	inosine-5'-monophosphate	inosine-5'-monophosphate	NOUN
biomedich-1021	1	61	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	1	62	(	(	PUNCT
biomedich-1021	1	63	impdh	impdh	NOUN
biomedich-1021	1	64	)	)	PUNCT
biomedich-1021	1	65	septi	septi	NOUN
biomedich-1021	1	66	handayani1	handayani1	NOUN
biomedich-1021	1	67	*	*	NOUN
biomedich-1021	1	68	,	,	PUNCT
biomedich-1021	1	69	nawan2	nawan2	PROPN
biomedich-1021	1	70	,	,	PUNCT
biomedich-1021	1	71	agnes	agnes	PROPN
biomedich-1021	1	72	immanuela	immanuela	CCONJ
biomedich-1021	1	73	toemon3	toemon3	PROPN
biomedich-1021	1	74	1departement	1departement	NUM
biomedich-1021	1	75	of	of	ADP
biomedich-1021	1	76	biochemistry	biochemistry	NOUN
biomedich-1021	1	77	;	;	PUNCT
biomedich-1021	1	78	2departement	2departement	NUM
biomedich-1021	1	79	of	of	ADP
biomedich-1021	1	80	microbiology	microbiology	NOUN
biomedich-1021	1	81	;	;	PUNCT
biomedich-1021	1	82	3departement	3departement	NUM
biomedich-1021	1	83	of	of	ADP
biomedich-1021	1	84	parasitology	parasitology	NOUN
biomedich-1021	1	85	,	,	PUNCT
biomedich-1021	1	86	faculty	faculty	NOUN
biomedich-1021	1	87	of	of	ADP
biomedich-1021	1	88	medicine	medicine	NOUN
biomedich-1021	1	89	,	,	PUNCT
biomedich-1021	1	90	university	university	PROPN
biomedich-1021	1	91	of	of	ADP
biomedich-1021	1	92	palangka	palangka	PROPN
biomedich-1021	1	93	raya	raya	PROPN
biomedich-1021	1	94	,	,	PUNCT
biomedich-1021	1	95	indonesia	indonesia	PROPN
biomedich-1021	1	96	.	.	PUNCT
biomedich-1021	2	1	corresponding	correspond	VERB
biomedich-1021	2	2	author	author	NOUN
biomedich-1021	2	3	*	*	X
biomedich-1021	2	4	septi@med.upr.ac.id	septi@med.upr.ac.id	X
biomedich-1021	2	5	abstract	abstract	ADV
biomedich-1021	2	6	the	the	DET
biomedich-1021	2	7	emergence	emergence	NOUN
biomedich-1021	2	8	of	of	ADP
biomedich-1021	2	9	multidrug	multidrug	NOUN
biomedich-1021	2	10	-	-	PUNCT
biomedich-1021	2	11	resistant	resistant	ADJ
biomedich-1021	2	12	streptococcus	streptococcus	NOUN
biomedich-1021	2	13	pyogenes	pyogene	NOUN
biomedich-1021	2	14	presents	present	VERB
biomedich-1021	2	15	a	a	DET
biomedich-1021	2	16	significant	significant	ADJ
biomedich-1021	2	17	global	global	ADJ
biomedich-1021	2	18	health	health	NOUN
biomedich-1021	2	19	threat	threat	NOUN
biomedich-1021	2	20	,	,	PUNCT
biomedich-1021	2	21	demanding	demand	VERB
biomedich-1021	2	22	the	the	DET
biomedich-1021	2	23	urgent	urgent	ADJ
biomedich-1021	2	24	discovery	discovery	NOUN
biomedich-1021	2	25	of	of	ADP
biomedich-1021	2	26	novel	novel	ADJ
biomedich-1021	2	27	antibacterial	antibacterial	ADJ
biomedich-1021	2	28	agents	agent	NOUN
biomedich-1021	2	29	.	.	PUNCT
biomedich-1021	3	1	this	this	DET
biomedich-1021	3	2	study	study	NOUN
biomedich-1021	3	3	utilized	utilize	VERB
biomedich-1021	3	4	a	a	DET
biomedich-1021	3	5	comprehensive	comprehensive	ADJ
biomedich-1021	3	6	in	in	ADP
biomedich-1021	3	7	silico	silico	NOUN
biomedich-1021	3	8	framework	framework	NOUN
biomedich-1021	3	9	to	to	PART
biomedich-1021	3	10	investigate	investigate	VERB
biomedich-1021	3	11	17	17	NUM
biomedich-1021	3	12	compounds	compound	NOUN
biomedich-1021	3	13	from	from	ADP
biomedich-1021	3	14	the	the	DET
biomedich-1021	3	15	traditional	traditional	ADJ
biomedich-1021	3	16	medicinal	medicinal	ADJ
biomedich-1021	3	17	plant	plant	NOUN
biomedich-1021	3	18	dracaena	dracaena	ADJ
biomedich-1021	3	19	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	3	20	as	as	ADP
biomedich-1021	3	21	potential	potential	ADJ
biomedich-1021	3	22	inhibitors	inhibitor	NOUN
biomedich-1021	3	23	of	of	ADP
biomedich-1021	3	24	inosine-5'-monophosphate	inosine-5'-monophosphate	NOUN
biomedich-1021	3	25	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	3	26	(	(	PUNCT
biomedich-1021	3	27	impdh	impdh	NOUN
biomedich-1021	3	28	)	)	PUNCT
biomedich-1021	3	29	,	,	PUNCT
biomedich-1021	3	30	a	a	DET
biomedich-1021	3	31	validated	validate	VERB
biomedich-1021	3	32	antimicrobial	antimicrobial	ADJ
biomedich-1021	3	33	drug	drug	NOUN
biomedich-1021	3	34	target	target	NOUN
biomedich-1021	3	35	.	.	PUNCT
biomedich-1021	4	1	the	the	DET
biomedich-1021	4	2	workflow	workflow	NOUN
biomedich-1021	4	3	included	include	VERB
biomedich-1021	4	4	predictive	predictive	ADJ
biomedich-1021	4	5	modeling	modeling	NOUN
biomedich-1021	4	6	of	of	ADP
biomedich-1021	4	7	physicochemical	physicochemical	ADJ
biomedich-1021	4	8	properties	property	NOUN
biomedich-1021	4	9	,	,	PUNCT
biomedich-1021	4	10	pharmacokinetics	pharmacokinetic	NOUN
biomedich-1021	4	11	(	(	PUNCT
biomedich-1021	4	12	adme	adme	NOUN
biomedich-1021	4	13	)	)	PUNCT
biomedich-1021	4	14	,	,	PUNCT
biomedich-1021	4	15	toxicity	toxicity	NOUN
biomedich-1021	4	16	profiles	profile	NOUN
biomedich-1021	4	17	,	,	PUNCT
biomedich-1021	4	18	and	and	CCONJ
biomedich-1021	4	19	molecular	molecular	ADJ
biomedich-1021	4	20	docking	docking	NOUN
biomedich-1021	4	21	simulations	simulation	NOUN
biomedich-1021	4	22	to	to	PART
biomedich-1021	4	23	elucidate	elucidate	VERB
biomedich-1021	4	24	binding	bind	VERB
biomedich-1021	4	25	affinities	affinity	NOUN
biomedich-1021	4	26	and	and	CCONJ
biomedich-1021	4	27	interaction	interaction	NOUN
biomedich-1021	4	28	patterns	pattern	NOUN
biomedich-1021	4	29	within	within	ADP
biomedich-1021	4	30	the	the	DET
biomedich-1021	4	31	enzyme	enzyme	NOUN
biomedich-1021	4	32	's	's	PART
biomedich-1021	4	33	active	active	ADJ
biomedich-1021	4	34	site	site	NOUN
biomedich-1021	4	35	.	.	PUNCT
biomedich-1021	5	1	physicochemical	physicochemical	ADJ
biomedich-1021	5	2	analysis	analysis	NOUN
biomedich-1021	5	3	revealed	reveal	VERB
biomedich-1021	5	4	that	that	SCONJ
biomedich-1021	5	5	11	11	NUM
biomedich-1021	5	6	of	of	ADP
biomedich-1021	5	7	the	the	DET
biomedich-1021	5	8	17	17	NUM
biomedich-1021	5	9	compounds	compound	NOUN
biomedich-1021	5	10	exhibited	exhibit	VERB
biomedich-1021	5	11	drug	drug	NOUN
biomedich-1021	5	12	-	-	PUNCT
biomedich-1021	5	13	like	like	ADJ
biomedich-1021	5	14	properties	property	NOUN
biomedich-1021	5	15	.	.	PUNCT
biomedich-1021	6	1	molecular	molecular	ADJ
biomedich-1021	6	2	docking	docking	NOUN
biomedich-1021	6	3	identified	identify	VERB
biomedich-1021	6	4	several	several	ADJ
biomedich-1021	6	5	ligands	ligand	NOUN
biomedich-1021	6	6	with	with	ADP
biomedich-1021	6	7	high	high	ADJ
biomedich-1021	6	8	binding	bind	VERB
biomedich-1021	6	9	affinities	affinity	NOUN
biomedich-1021	6	10	,	,	PUNCT
biomedich-1021	6	11	notably	notably	ADV
biomedich-1021	6	12	isopimaric	isopimaric	ADJ
biomedich-1021	6	13	acid	acid	NOUN
biomedich-1021	6	14	(	(	PUNCT
biomedich-1021	6	15	-8.2	-8.2	PROPN
biomedich-1021	6	16	kcal	kcal	PROPN
biomedich-1021	6	17	/	/	SYM
biomedich-1021	6	18	mol	mol	NOUN
biomedich-1021	6	19	)	)	PUNCT
biomedich-1021	6	20	and	and	CCONJ
biomedich-1021	6	21	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	6	22	d	d	PROPN
biomedich-1021	6	23	(	(	PUNCT
biomedich-1021	6	24	-8.1	-8.1	PROPN
biomedich-1021	6	25	kcal	kcal	PROPN
biomedich-1021	6	26	/	/	SYM
biomedich-1021	6	27	mol	mol	PROPN
biomedich-1021	6	28	)	)	PUNCT
biomedich-1021	6	29	,	,	PUNCT
biomedich-1021	6	30	whose	whose	DET
biomedich-1021	6	31	stability	stability	NOUN
biomedich-1021	6	32	was	be	AUX
biomedich-1021	6	33	mediated	mediate	VERB
biomedich-1021	6	34	by	by	ADP
biomedich-1021	6	35	interactions	interaction	NOUN
biomedich-1021	6	36	with	with	ADP
biomedich-1021	6	37	key	key	ADJ
biomedich-1021	6	38	catalytic	catalytic	ADJ
biomedich-1021	6	39	residues	residue	NOUN
biomedich-1021	6	40	.	.	PUNCT
biomedich-1021	7	1	admet	admet	PROPN
biomedich-1021	7	2	predictions	prediction	NOUN
biomedich-1021	7	3	indicated	indicate	VERB
biomedich-1021	7	4	that	that	SCONJ
biomedich-1021	7	5	most	most	ADJ
biomedich-1021	7	6	compounds	compound	NOUN
biomedich-1021	7	7	possess	possess	VERB
biomedich-1021	7	8	favorable	favorable	ADJ
biomedich-1021	7	9	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	7	10	profiles	profile	NOUN
biomedich-1021	7	11	.	.	PUNCT
biomedich-1021	8	1	crucially	crucially	ADV
biomedich-1021	8	2	,	,	PUNCT
biomedich-1021	8	3	isopimaric	isopimaric	ADJ
biomedich-1021	8	4	acid	acid	PROPN
biomedich-1021	8	5	demonstrated	demonstrate	VERB
biomedich-1021	8	6	a	a	DET
biomedich-1021	8	7	superior	superior	ADJ
biomedich-1021	8	8	safety	safety	NOUN
biomedich-1021	8	9	profile	profile	NOUN
biomedich-1021	8	10	,	,	PUNCT
biomedich-1021	8	11	with	with	ADP
biomedich-1021	8	12	a	a	DET
biomedich-1021	8	13	high	high	ADJ
biomedich-1021	8	14	ld50	ld50	PROPN
biomedich-1021	8	15	(	(	PUNCT
biomedich-1021	8	16	5000	5000	NUM
biomedich-1021	8	17	mg	mg	PROPN
biomedich-1021	8	18	/	/	SYM
biomedich-1021	8	19	kg	kg	PROPN
biomedich-1021	8	20	)	)	PUNCT
biomedich-1021	8	21	,	,	PUNCT
biomedich-1021	8	22	no	no	DET
biomedich-1021	8	23	predicted	predict	VERB
biomedich-1021	8	24	mutagenicity	mutagenicity	NOUN
biomedich-1021	8	25	,	,	PUNCT
biomedich-1021	8	26	and	and	CCONJ
biomedich-1021	8	27	no	no	DET
biomedich-1021	8	28	risk	risk	NOUN
biomedich-1021	8	29	of	of	ADP
biomedich-1021	8	30	drug	drug	NOUN
biomedich-1021	8	31	-	-	PUNCT
biomedich-1021	8	32	induced	induce	VERB
biomedich-1021	8	33	liver	liver	NOUN
biomedich-1021	8	34	injury	injury	NOUN
biomedich-1021	8	35	(	(	PUNCT
biomedich-1021	8	36	dili	dili	PROPN
biomedich-1021	8	37	)	)	PUNCT
biomedich-1021	8	38	.	.	PUNCT
biomedich-1021	9	1	this	this	DET
biomedich-1021	9	2	computational	computational	ADJ
biomedich-1021	9	3	investigation	investigation	NOUN
biomedich-1021	9	4	successfully	successfully	ADV
biomedich-1021	9	5	identified	identify	VERB
biomedich-1021	9	6	isopimaric	isopimaric	ADJ
biomedich-1021	9	7	acid	acid	NOUN
biomedich-1021	9	8	as	as	ADP
biomedich-1021	9	9	a	a	DET
biomedich-1021	9	10	standout	standout	NOUN
biomedich-1021	9	11	candidate	candidate	NOUN
biomedich-1021	9	12	,	,	PUNCT
biomedich-1021	9	13	and	and	CCONJ
biomedich-1021	9	14	its	its	PRON
biomedich-1021	9	15	combination	combination	NOUN
biomedich-1021	9	16	of	of	ADP
biomedich-1021	9	17	strong	strong	ADJ
biomedich-1021	9	18	target	target	NOUN
biomedich-1021	9	19	affinity	affinity	NOUN
biomedich-1021	9	20	and	and	CCONJ
biomedich-1021	9	21	a	a	DET
biomedich-1021	9	22	favorable	favorable	ADJ
biomedich-1021	9	23	admet	admet	NOUN
biomedich-1021	9	24	profile	profile	NOUN
biomedich-1021	9	25	positions	position	VERB
biomedich-1021	9	26	it	it	PRON
biomedich-1021	9	27	as	as	ADP
biomedich-1021	9	28	a	a	DET
biomedich-1021	9	29	promising	promising	ADJ
biomedich-1021	9	30	scaffold	scaffold	NOUN
biomedich-1021	9	31	for	for	ADP
biomedich-1021	9	32	the	the	DET
biomedich-1021	9	33	development	development	NOUN
biomedich-1021	9	34	of	of	ADP
biomedich-1021	9	35	novel	novel	ADJ
biomedich-1021	9	36	antibacterial	antibacterial	ADJ
biomedich-1021	9	37	agents	agent	NOUN
biomedich-1021	9	38	against	against	ADP
biomedich-1021	9	39	s.	s.	PROPN
biomedich-1021	9	40	pyogenes	pyogenes	PROPN
biomedich-1021	9	41	.	.	PUNCT
biomedich-1021	10	1	these	these	DET
biomedich-1021	10	2	findings	finding	NOUN
biomedich-1021	10	3	provide	provide	VERB
biomedich-1021	10	4	a	a	DET
biomedich-1021	10	5	strong	strong	ADJ
biomedich-1021	10	6	impetus	impetus	NOUN
biomedich-1021	10	7	for	for	ADP
biomedich-1021	10	8	experimental	experimental	ADJ
biomedich-1021	10	9	validation	validation	NOUN
biomedich-1021	10	10	.	.	PUNCT
biomedich-1021	11	1	keywords	keyword	NOUN
biomedich-1021	11	2	:	:	PUNCT
biomedich-1021	11	3	admet	admet	ADJ
biomedich-1021	11	4	;	;	PUNCT
biomedich-1021	11	5	antibiotic	antibiotic	ADJ
biomedich-1021	11	6	resistance	resistance	NOUN
biomedich-1021	11	7	;	;	PUNCT
biomedich-1021	11	8	dracaena	dracaena	ADJ
biomedich-1021	11	9	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	11	10	;	;	PUNCT
biomedich-1021	11	11	impdh	impdh	NOUN
biomedich-1021	11	12	;	;	PUNCT
biomedich-1021	11	13	molecular	molecular	ADJ
biomedich-1021	11	14	docking	docking	NOUN
biomedich-1021	11	15	;	;	PUNCT
biomedich-1021	11	16	streptococcus	streptococcus	NOUN
biomedich-1021	11	17	pyogenes	pyogene	NOUN
biomedich-1021	11	18	.	.	PUNCT
biomedich-1021	12	1	abbreviations	abbreviation	NOUN
biomedich-1021	12	2	:	:	PUNCT
biomedich-1021	12	3	adme	adme	NOUN
biomedich-1021	12	4	:	:	PUNCT
biomedich-1021	12	5	absorption	absorption	NOUN
biomedich-1021	12	6	,	,	PUNCT
biomedich-1021	12	7	distribution	distribution	NOUN
biomedich-1021	12	8	,	,	PUNCT
biomedich-1021	12	9	metabolism	metabolism	NOUN
biomedich-1021	12	10	,	,	PUNCT
biomedich-1021	12	11	excretion	excretion	NOUN
biomedich-1021	12	12	;	;	PUNCT
biomedich-1021	12	13	dili	dili	PROPN
biomedich-1021	12	14	:	:	PUNCT
biomedich-1021	12	15	drug	drug	NOUN
biomedich-1021	12	16	-	-	PUNCT
biomedich-1021	12	17	induced	induce	VERB
biomedich-1021	12	18	liver	liver	NOUN
biomedich-1021	12	19	injury	injury	NOUN
biomedich-1021	12	20	;	;	PUNCT
biomedich-1021	12	21	impdh	impdh	NOUN
biomedich-1021	12	22	:	:	PUNCT
biomedich-1021	12	23	inosine-5'monophosphate	inosine-5'monophosphate	PROPN
biomedich-1021	12	24	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	12	25	;	;	PUNCT
biomedich-1021	12	26	ld50	ld50	PROPN
biomedich-1021	12	27	:	:	PUNCT
biomedich-1021	12	28	lethal	lethal	ADJ
biomedich-1021	12	29	dose	dose	NOUN
biomedich-1021	12	30	50	50	NUM
biomedich-1021	12	31	.	.	PUNCT
biomedich-1021	13	1	introduction	introduction	NOUN
biomedich-1021	13	2	streptococcus	streptococcus	NOUN
biomedich-1021	13	3	pyogenes	pyogene	NOUN
biomedich-1021	13	4	remains	remain	VERB
biomedich-1021	13	5	a	a	DET
biomedich-1021	13	6	significant	significant	ADJ
biomedich-1021	13	7	bacterial	bacterial	ADJ
biomedich-1021	13	8	pathogen	pathogen	NOUN
biomedich-1021	13	9	,	,	PUNCT
biomedich-1021	13	10	responsible	responsible	ADJ
biomedich-1021	13	11	for	for	ADP
biomedich-1021	13	12	a	a	DET
biomedich-1021	13	13	wide	wide	ADJ
biomedich-1021	13	14	spectrum	spectrum	NOUN
biomedich-1021	13	15	of	of	ADP
biomedich-1021	13	16	human	human	ADJ
biomedich-1021	13	17	diseases	disease	NOUN
biomedich-1021	13	18	ranging	range	VERB
biomedich-1021	13	19	from	from	ADP
biomedich-1021	13	20	mild	mild	ADJ
biomedich-1021	13	21	localized	localized	ADJ
biomedich-1021	13	22	infections	infection	NOUN
biomedich-1021	13	23	to	to	ADP
biomedich-1021	13	24	severe	severe	ADJ
biomedich-1021	13	25	,	,	PUNCT
biomedich-1021	13	26	life	life	NOUN
biomedich-1021	13	27	-	-	PUNCT
biomedich-1021	13	28	threatening	threaten	VERB
biomedich-1021	13	29	invasive	invasive	ADJ
biomedich-1021	13	30	conditions	condition	NOUN
biomedich-1021	13	31	(	(	PUNCT
biomedich-1021	13	32	kanwal	kanwal	PROPN
biomedich-1021	13	33	&	&	CCONJ
biomedich-1021	13	34	vaitla	vaitla	PROPN
biomedich-1021	13	35	,	,	PUNCT
biomedich-1021	13	36	2023	2023	NUM
biomedich-1021	13	37	)	)	PUNCT
biomedich-1021	13	38	.	.	PUNCT
biomedich-1021	14	1	this	this	DET
biomedich-1021	14	2	gram	gram	NOUN
biomedich-1021	14	3	-	-	PUNCT
biomedich-1021	14	4	positive	positive	ADJ
biomedich-1021	14	5	bacterium	bacterium	NOUN
biomedich-1021	14	6	is	be	AUX
biomedich-1021	14	7	a	a	DET
biomedich-1021	14	8	primary	primary	ADJ
biomedich-1021	14	9	cause	cause	NOUN
biomedich-1021	14	10	of	of	ADP
biomedich-1021	14	11	millions	million	NOUN
biomedich-1021	14	12	of	of	ADP
biomedich-1021	14	13	cases	case	NOUN
biomedich-1021	14	14	of	of	ADP
biomedich-1021	14	15	pharyngitis	pharyngitis	ADJ
biomedich-1021	14	16	and	and	CCONJ
biomedich-1021	14	17	invasive	invasive	ADJ
biomedich-1021	14	18	infections	infection	NOUN
biomedich-1021	14	19	annually	annually	ADV
biomedich-1021	14	20	,	,	PUNCT
biomedich-1021	14	21	contributing	contribute	VERB
biomedich-1021	14	22	to	to	ADP
biomedich-1021	14	23	substantial	substantial	ADJ
biomedich-1021	14	24	global	global	ADJ
biomedich-1021	14	25	morbidity	morbidity	NOUN
biomedich-1021	14	26	and	and	CCONJ
biomedich-1021	14	27	mortality	mortality	NOUN
biomedich-1021	14	28	(	(	PUNCT
biomedich-1021	14	29	kebede	kebede	PROPN
biomedich-1021	14	30	et	et	PROPN
biomedich-1021	14	31	al	al	PROPN
biomedich-1021	14	32	.	.	PROPN
biomedich-1021	14	33	,	,	PUNCT
biomedich-1021	14	34	2021	2021	NUM
biomedich-1021	14	35	)	)	PUNCT
biomedich-1021	14	36	.	.	PUNCT
biomedich-1021	15	1	the	the	DET
biomedich-1021	15	2	primary	primary	ADJ
biomedich-1021	15	3	line	line	NOUN
biomedich-1021	15	4	of	of	ADP
biomedich-1021	15	5	treatment	treatment	NOUN
biomedich-1021	15	6	for	for	ADP
biomedich-1021	15	7	s.	s.	PROPN
biomedich-1021	15	8	pyogenes	pyogenes	PROPN
biomedich-1021	15	9	infections	infection	NOUN
biomedich-1021	15	10	has	have	AUX
biomedich-1021	15	11	traditionally	traditionally	ADV
biomedich-1021	15	12	been	be	AUX
biomedich-1021	15	13	β	β	NOUN
biomedich-1021	15	14	-	-	NOUN
biomedich-1021	15	15	lactam	lactam	NOUN
biomedich-1021	15	16	antibiotics	antibiotic	NOUN
biomedich-1021	15	17	,	,	PUNCT
biomedich-1021	15	18	such	such	ADJ
biomedich-1021	15	19	as	as	ADP
biomedich-1021	15	20	penicillin	penicillin	PROPN
biomedich-1021	15	21	.	.	PUNCT
biomedich-1021	16	1	however	however	ADV
biomedich-1021	16	2	,	,	PUNCT
biomedich-1021	16	3	the	the	DET
biomedich-1021	16	4	emergence	emergence	NOUN
biomedich-1021	16	5	of	of	ADP
biomedich-1021	16	6	strains	strain	NOUN
biomedich-1021	16	7	with	with	ADP
biomedich-1021	16	8	reduced	reduce	VERB
biomedich-1021	16	9	susceptibility	susceptibility	NOUN
biomedich-1021	16	10	and	and	CCONJ
biomedich-1021	16	11	outright	outright	ADJ
biomedich-1021	16	12	resistance	resistance	NOUN
biomedich-1021	16	13	to	to	ADP
biomedich-1021	16	14	multiple	multiple	ADJ
biomedich-1021	16	15	antibiotic	antibiotic	ADJ
biomedich-1021	16	16	classes	class	NOUN
biomedich-1021	16	17	,	,	PUNCT
biomedich-1021	16	18	including	include	VERB
biomedich-1021	16	19	macrolides	macrolide	NOUN
biomedich-1021	16	20	and	and	CCONJ
biomedich-1021	16	21	fluoroquinolones	fluoroquinolone	NOUN
biomedich-1021	16	22	,	,	PUNCT
biomedich-1021	16	23	poses	pose	VERB
biomedich-1021	16	24	a	a	DET
biomedich-1021	16	25	critical	critical	ADJ
biomedich-1021	16	26	threat	threat	NOUN
biomedich-1021	16	27	to	to	ADP
biomedich-1021	16	28	public	public	ADJ
biomedich-1021	16	29	health	health	NOUN
biomedich-1021	16	30	(	(	PUNCT
biomedich-1021	16	31	cattoir	cattoir	NOUN
biomedich-1021	16	32	,	,	PUNCT
biomedich-1021	16	33	2022	2022	NUM
biomedich-1021	16	34	;	;	PUNCT
biomedich-1021	16	35	ünübol	ünübol	NOUN
biomedich-1021	16	36	et	et	PROPN
biomedich-1021	16	37	al	al	PROPN
biomedich-1021	16	38	.	.	PROPN
biomedich-1021	16	39	,	,	PUNCT
biomedich-1021	16	40	2025	2025	NUM
biomedich-1021	16	41	)	)	PUNCT
biomedich-1021	16	42	.	.	PUNCT
biomedich-1021	17	1	high	high	ADJ
biomedich-1021	17	2	rates	rate	NOUN
biomedich-1021	17	3	of	of	ADP
biomedich-1021	17	4	resistance	resistance	NOUN
biomedich-1021	17	5	have	have	AUX
biomedich-1021	17	6	been	be	AUX
biomedich-1021	17	7	documented	document	VERB
biomedich-1021	17	8	globally	globally	ADV
biomedich-1021	17	9	,	,	PUNCT
biomedich-1021	17	10	limiting	limit	VERB
biomedich-1021	17	11	therapeutic	therapeutic	ADJ
biomedich-1021	17	12	options	option	NOUN
biomedich-1021	17	13	and	and	CCONJ
biomedich-1021	17	14	increasing	increase	VERB
biomedich-1021	17	15	the	the	DET
biomedich-1021	17	16	risk	risk	NOUN
biomedich-1021	17	17	of	of	ADP
biomedich-1021	17	18	treatment	treatment	NOUN
biomedich-1021	17	19	failure	failure	NOUN
biomedich-1021	17	20	.	.	PUNCT
biomedich-1021	18	1	this	this	DET
biomedich-1021	18	2	escalating	escalate	VERB
biomedich-1021	18	3	crisis	crisis	NOUN
biomedich-1021	18	4	underscores	underscore	VERB
biomedich-1021	18	5	the	the	DET
biomedich-1021	18	6	urgent	urgent	ADJ
biomedich-1021	18	7	need	need	NOUN
biomedich-1021	18	8	to	to	PART
biomedich-1021	18	9	explore	explore	VERB
biomedich-1021	18	10	and	and	CCONJ
biomedich-1021	18	11	develop	develop	VERB
biomedich-1021	18	12	novel	novel	ADJ
biomedich-1021	18	13	antibacterial	antibacterial	ADJ
biomedich-1021	18	14	agents	agent	NOUN
biomedich-1021	18	15	with	with	ADP
biomedich-1021	18	16	alternative	alternative	ADJ
biomedich-1021	18	17	mechanisms	mechanism	NOUN
biomedich-1021	18	18	of	of	ADP
biomedich-1021	18	19	action	action	NOUN
biomedich-1021	18	20	(	(	PUNCT
biomedich-1021	18	21	nawan	nawan	NOUN
biomedich-1021	18	22	et	et	NOUN
biomedich-1021	18	23	al	al	PROPN
biomedich-1021	18	24	.	.	PROPN
biomedich-1021	18	25	,	,	PUNCT
biomedich-1021	18	26	2020	2020	NUM
biomedich-1021	18	27	;	;	PUNCT
biomedich-1021	18	28	nawan	nawan	PROPN
biomedich-1021	18	29	&	&	CCONJ
biomedich-1021	18	30	handayani	handayani	PROPN
biomedich-1021	18	31	,	,	PUNCT
biomedich-1021	18	32	2021	2021	NUM
biomedich-1021	18	33	)	)	PUNCT
biomedich-1021	18	34	.	.	PUNCT
biomedich-1021	19	1	natural	natural	ADJ
biomedich-1021	19	2	products	product	NOUN
biomedich-1021	19	3	,	,	PUNCT
biomedich-1021	19	4	particularly	particularly	ADV
biomedich-1021	19	5	those	those	PRON
biomedich-1021	19	6	derived	derive	VERB
biomedich-1021	19	7	from	from	ADP
biomedich-1021	19	8	medicinal	medicinal	ADJ
biomedich-1021	19	9	plants	plant	NOUN
biomedich-1021	19	10	,	,	PUNCT
biomedich-1021	19	11	represent	represent	VERB
biomedich-1021	19	12	a	a	DET
biomedich-1021	19	13	rich	rich	ADJ
biomedich-1021	19	14	reservoir	reservoir	NOUN
biomedich-1021	19	15	for	for	ADP
biomedich-1021	19	16	drug	drug	NOUN
biomedich-1021	19	17	discovery	discovery	NOUN
biomedich-1021	19	18	.	.	PUNCT
biomedich-1021	20	1	the	the	DET
biomedich-1021	20	2	red	red	ADJ
biomedich-1021	20	3	resin	resin	NOUN
biomedich-1021	20	4	of	of	ADP
biomedich-1021	20	5	dracaena	dracaena	ADJ
biomedich-1021	20	6	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	20	7	,	,	PUNCT
biomedich-1021	20	8	commonly	commonly	ADV
biomedich-1021	20	9	known	know	VERB
biomedich-1021	20	10	as	as	ADP
biomedich-1021	20	11	"	"	PUNCT
biomedich-1021	20	12	dragon	dragon	NOUN
biomedich-1021	20	13	's	's	PART
biomedich-1021	20	14	blood	blood	NOUN
biomedich-1021	20	15	,	,	PUNCT
biomedich-1021	20	16	"	"	PUNCT
biomedich-1021	20	17	has	have	VERB
biomedich-1021	20	18	a	a	DET
biomedich-1021	20	19	long	long	ADJ
biomedich-1021	20	20	history	history	NOUN
biomedich-1021	20	21	of	of	ADP
biomedich-1021	20	22	use	use	NOUN
biomedich-1021	20	23	in	in	ADP
biomedich-1021	20	24	traditional	traditional	ADJ
biomedich-1021	20	25	chinese	chinese	ADJ
biomedich-1021	20	26	medicine	medicine	NOUN
biomedich-1021	20	27	for	for	ADP
biomedich-1021	20	28	treating	treat	VERB
biomedich-1021	20	29	various	various	ADJ
biomedich-1021	20	30	ailments	ailment	NOUN
biomedich-1021	20	31	.	.	PUNCT
biomedich-1021	21	1	modern	modern	ADJ
biomedich-1021	21	2	scientific	scientific	ADJ
biomedich-1021	21	3	studies	study	NOUN
biomedich-1021	21	4	have	have	AUX
biomedich-1021	21	5	validated	validate	VERB
biomedich-1021	21	6	its	its	PRON
biomedich-1021	21	7	broad	broad	ADJ
biomedich-1021	21	8	spectrum	spectrum	NOUN
biomedich-1021	21	9	of	of	ADP
biomedich-1021	21	10	bioactivities	bioactivitie	NOUN
biomedich-1021	21	11	,	,	PUNCT
biomedich-1021	21	12	including	include	VERB
biomedich-1021	21	13	anti	anti	ADJ
biomedich-1021	21	14	-	-	ADJ
biomedich-1021	21	15	inflammatory	inflammatory	ADJ
biomedich-1021	21	16	,	,	PUNCT
biomedich-1021	21	17	anti	anti	ADJ
biomedich-1021	21	18	-	-	ADJ
biomedich-1021	21	19	tumor	tumor	ADJ
biomedich-1021	21	20	,	,	PUNCT
biomedich-1021	21	21	and	and	CCONJ
biomedich-1021	21	22	antibacterial	antibacterial	ADJ
biomedich-1021	21	23	properties	property	NOUN
biomedich-1021	21	24	(	(	PUNCT
biomedich-1021	21	25	gupta	gupta	PROPN
biomedich-1021	21	26	&	&	CCONJ
biomedich-1021	21	27	gupta	gupta	PROPN
biomedich-1021	21	28	,	,	PUNCT
biomedich-1021	21	29	2011	2011	NUM
biomedich-1021	21	30	;	;	PUNCT
biomedich-1021	21	31	he	he	PRON
biomedich-1021	21	32	et	et	PROPN
biomedich-1021	21	33	al	al	PROPN
biomedich-1021	21	34	.	.	PROPN
biomedich-1021	21	35	,	,	PUNCT
biomedich-1021	21	36	2021	2021	NUM
biomedich-1021	21	37	)	)	PUNCT
biomedich-1021	21	38	.	.	PUNCT
biomedich-1021	22	1	effective	effective	ADJ
biomedich-1021	22	2	antibacterial	antibacterial	ADJ
biomedich-1021	22	3	drug	drug	NOUN
biomedich-1021	22	4	development	development	NOUN
biomedich-1021	22	5	hinges	hinge	NOUN
biomedich-1021	22	6	on	on	ADP
biomedich-1021	22	7	the	the	DET
biomedich-1021	22	8	identification	identification	NOUN
biomedich-1021	22	9	of	of	ADP
biomedich-1021	22	10	essential	essential	ADJ
biomedich-1021	22	11	molecular	molecular	ADJ
biomedich-1021	22	12	targets	target	NOUN
biomedich-1021	22	13	within	within	ADP
biomedich-1021	22	14	the	the	DET
biomedich-1021	22	15	pathogen	pathogen	NOUN
biomedich-1021	22	16	.	.	PUNCT
biomedich-1021	23	1	inosine-5'-monophosphate	inosine-5'-monophosphate	NOUN
biomedich-1021	23	2	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	23	3	(	(	PUNCT
biomedich-1021	23	4	impdh	impdh	NOUN
biomedich-1021	23	5	)	)	PUNCT
biomedich-1021	23	6	is	be	AUX
biomedich-1021	23	7	a	a	DET
biomedich-1021	23	8	rate	rate	NOUN
biomedich-1021	23	9	-	-	PUNCT
biomedich-1021	23	10	limiting	limit	VERB
biomedich-1021	23	11	enzyme	enzyme	NOUN
biomedich-1021	23	12	in	in	ADP
biomedich-1021	23	13	the	the	DET
biomedich-1021	23	14	de	de	X
biomedich-1021	23	15	novo	novo	NOUN
biomedich-1021	23	16	biosynthesis	biosynthesis	NOUN
biomedich-1021	23	17	of	of	ADP
biomedich-1021	23	18	guanine	guanine	NOUN
biomedich-1021	23	19	nucleotides	nucleotide	NOUN
biomedich-1021	23	20	,	,	PUNCT
biomedich-1021	23	21	which	which	PRON
biomedich-1021	23	22	are	be	AUX
biomedich-1021	23	23	manuscript	manuscript	NOUN
biomedich-1021	23	24	received	receive	VERB
biomedich-1021	23	25	:	:	PUNCT
biomedich-1021	23	26	04	04	NUM
biomedich-1021	23	27	october	october	PROPN
biomedich-1021	23	28	,	,	PUNCT
biomedich-1021	23	29	2025	2025	NUM
biomedich-1021	23	30	.	.	PUNCT
biomedich-1021	24	1	revision	revision	NOUN
biomedich-1021	24	2	accepted	accept	VERB
biomedich-1021	24	3	:	:	PUNCT
biomedich-1021	24	4	04	04	NUM
biomedich-1021	24	5	december	december	NOUN
biomedich-1021	24	6	,	,	PUNCT
biomedich-1021	24	7	2025	2025	NUM
biomedich-1021	24	8	.	.	PUNCT
biomedich-1021	25	1	published	publish	VERB
biomedich-1021	25	2	:	:	PUNCT
biomedich-1021	25	3	13	13	NUM
biomedich-1021	25	4	december	december	NOUN
biomedich-1021	25	5	,	,	PUNCT
biomedich-1021	25	6	2025	2025	NUM
biomedich-1021	25	7	.	.	PUNCT
biomedich-1021	26	1	https://doi.org/10.14421/biomedich.2025.142.1265-1271	https://doi.org/10.14421/biomedich.2025.142.1265-1271	NOUN
biomedich-1021	26	2	1266	1266	NUM
biomedich-1021	26	3	biology	biology	NOUN
biomedich-1021	26	4	,	,	PUNCT
biomedich-1021	26	5	medicine	medicine	NOUN
biomedich-1021	26	6	,	,	PUNCT
biomedich-1021	26	7	&	&	CCONJ
biomedich-1021	26	8	natural	natural	ADJ
biomedich-1021	26	9	product	product	NOUN
biomedich-1021	26	10	chemistry	chemistry	NOUN
biomedich-1021	26	11	14	14	NUM
biomedich-1021	26	12	(	(	PUNCT
biomedich-1021	26	13	2	2	NUM
biomedich-1021	26	14	)	)	PUNCT
biomedich-1021	26	15	,	,	PUNCT
biomedich-1021	26	16	2025	2025	NUM
biomedich-1021	26	17	:	:	PUNCT
biomedich-1021	26	18	1265	1265	NUM
biomedich-1021	26	19	-	-	SYM
biomedich-1021	26	20	1271	1271	NUM
biomedich-1021	26	21	indispensable	indispensable	ADJ
biomedich-1021	26	22	for	for	ADP
biomedich-1021	26	23	bacterial	bacterial	ADJ
biomedich-1021	26	24	dna	dna	PROPN
biomedich-1021	26	25	and	and	CCONJ
biomedich-1021	26	26	rna	rna	NOUN
biomedich-1021	26	27	synthesis	synthesis	NOUN
biomedich-1021	26	28	(	(	PUNCT
biomedich-1021	26	29	modi	modi	PROPN
biomedich-1021	26	30	et	et	PROPN
biomedich-1021	26	31	al	al	PROPN
biomedich-1021	26	32	.	.	PROPN
biomedich-1021	26	33	,	,	PUNCT
biomedich-1021	26	34	2021	2021	NUM
biomedich-1021	26	35	)	)	PUNCT
biomedich-1021	26	36	.	.	PUNCT
biomedich-1021	27	1	its	its	PRON
biomedich-1021	27	2	critical	critical	ADJ
biomedich-1021	27	3	role	role	NOUN
biomedich-1021	27	4	in	in	ADP
biomedich-1021	27	5	pathogen	pathogen	NOUN
biomedich-1021	27	6	viability	viability	NOUN
biomedich-1021	27	7	and	and	CCONJ
biomedich-1021	27	8	proliferation	proliferation	NOUN
biomedich-1021	27	9	has	have	AUX
biomedich-1021	27	10	established	establish	VERB
biomedich-1021	27	11	impdh	impdh	NOUN
biomedich-1021	27	12	as	as	ADP
biomedich-1021	27	13	a	a	DET
biomedich-1021	27	14	validated	validated	ADJ
biomedich-1021	27	15	and	and	CCONJ
biomedich-1021	27	16	attractive	attractive	ADJ
biomedich-1021	27	17	target	target	NOUN
biomedich-1021	27	18	for	for	ADP
biomedich-1021	27	19	novel	novel	ADJ
biomedich-1021	27	20	antibacterial	antibacterial	ADJ
biomedich-1021	27	21	agents	agent	NOUN
biomedich-1021	27	22	(	(	PUNCT
biomedich-1021	27	23	ramanujan	ramanujan	PROPN
biomedich-1021	27	24	,	,	PUNCT
biomedich-1021	27	25	2020	2020	NUM
biomedich-1021	27	26	)	)	PUNCT
biomedich-1021	27	27	.	.	PUNCT
biomedich-1021	28	1	this	this	DET
biomedich-1021	28	2	study	study	NOUN
biomedich-1021	28	3	aimed	aim	VERB
biomedich-1021	28	4	to	to	PART
biomedich-1021	28	5	investigate	investigate	VERB
biomedich-1021	28	6	the	the	DET
biomedich-1021	28	7	potential	potential	NOUN
biomedich-1021	28	8	of	of	ADP
biomedich-1021	28	9	bioactive	bioactive	ADJ
biomedich-1021	28	10	compounds	compound	NOUN
biomedich-1021	28	11	from	from	ADP
biomedich-1021	28	12	d.	d.	PROPN
biomedich-1021	28	13	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	28	14	as	as	ADP
biomedich-1021	28	15	inhibitors	inhibitor	NOUN
biomedich-1021	28	16	of	of	ADP
biomedich-1021	28	17	s.	s.	PROPN
biomedich-1021	28	18	pyogenes	pyogenes	PROPN
biomedich-1021	28	19	impdh	impdh	NOUN
biomedich-1021	28	20	through	through	ADP
biomedich-1021	28	21	a	a	DET
biomedich-1021	28	22	comprehensive	comprehensive	ADJ
biomedich-1021	28	23	computational	computational	ADJ
biomedich-1021	28	24	approach	approach	NOUN
biomedich-1021	28	25	.	.	PUNCT
biomedich-1021	29	1	by	by	ADP
biomedich-1021	29	2	integrating	integrate	VERB
biomedich-1021	29	3	molecular	molecular	ADJ
biomedich-1021	29	4	docking	docking	NOUN
biomedich-1021	29	5	simulations	simulation	NOUN
biomedich-1021	29	6	with	with	ADP
biomedich-1021	29	7	predictions	prediction	NOUN
biomedich-1021	29	8	of	of	ADP
biomedich-1021	29	9	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	29	10	(	(	PUNCT
biomedich-1021	29	11	adme	adme	NOUN
biomedich-1021	29	12	)	)	PUNCT
biomedich-1021	29	13	and	and	CCONJ
biomedich-1021	29	14	toxicity	toxicity	NOUN
biomedich-1021	29	15	profiles	profile	NOUN
biomedich-1021	29	16	,	,	PUNCT
biomedich-1021	29	17	we	we	PRON
biomedich-1021	29	18	identify	identify	VERB
biomedich-1021	29	19	the	the	DET
biomedich-1021	29	20	most	most	ADV
biomedich-1021	29	21	promising	promising	ADJ
biomedich-1021	29	22	lead	lead	NOUN
biomedich-1021	29	23	compounds	compound	NOUN
biomedich-1021	29	24	that	that	PRON
biomedich-1021	29	25	could	could	AUX
biomedich-1021	29	26	serve	serve	VERB
biomedich-1021	29	27	as	as	ADP
biomedich-1021	29	28	scaffolds	scaffold	NOUN
biomedich-1021	29	29	for	for	ADP
biomedich-1021	29	30	the	the	DET
biomedich-1021	29	31	development	development	NOUN
biomedich-1021	29	32	of	of	ADP
biomedich-1021	29	33	new	new	ADJ
biomedich-1021	29	34	therapeutics	therapeutic	NOUN
biomedich-1021	29	35	against	against	ADP
biomedich-1021	29	36	s.	s.	PROPN
biomedich-1021	29	37	pyogenes	pyogenes	PROPN
biomedich-1021	29	38	.	.	PUNCT
biomedich-1021	30	1	materials	material	NOUN
biomedich-1021	30	2	and	and	CCONJ
biomedich-1021	30	3	methods	method	NOUN
biomedich-1021	30	4	software	software	NOUN
biomedich-1021	30	5	and	and	CCONJ
biomedich-1021	30	6	computational	computational	ADJ
biomedich-1021	30	7	resources	resource	NOUN
biomedich-1021	30	8	all	all	DET
biomedich-1021	30	9	computational	computational	ADJ
biomedich-1021	30	10	tasks	task	NOUN
biomedich-1021	30	11	were	be	AUX
biomedich-1021	30	12	performed	perform	VERB
biomedich-1021	30	13	on	on	ADP
biomedich-1021	30	14	a	a	DET
biomedich-1021	30	15	pc	pc	NOUN
biomedich-1021	30	16	equipped	equip	VERB
biomedich-1021	30	17	with	with	ADP
biomedich-1021	30	18	an	an	DET
biomedich-1021	30	19	intel	intel	PROPN
biomedich-1021	30	20	®	®	NOUN
biomedich-1021	30	21	core	core	NOUN
biomedich-1021	30	22	™	™	ADJ
biomedich-1021	30	23	i7	i7	NOUN
biomedich-1021	30	24	-	-	PUNCT
biomedich-1021	30	25	5500u	5500u	NUM
biomedich-1021	30	26	cpu	cpu	NOUN
biomedich-1021	30	27	@	@	ADP
biomedich-1021	30	28	2.40ghz	2.40ghz	NUM
biomedich-1021	30	29	,	,	PUNCT
biomedich-1021	30	30	16	16	NUM
biomedich-1021	30	31	gb	gb	NOUN
biomedich-1021	30	32	of	of	ADP
biomedich-1021	30	33	ram	ram	NOUN
biomedich-1021	30	34	,	,	PUNCT
biomedich-1021	30	35	running	run	VERB
biomedich-1021	30	36	a	a	DET
biomedich-1021	30	37	windows	window	NOUN
biomedich-1021	30	38	11	11	NUM
biomedich-1021	30	39	pro	pro	ADJ
biomedich-1021	30	40	64	64	NUM
biomedich-1021	30	41	-	-	PUNCT
biomedich-1021	30	42	bit	bit	NOUN
biomedich-1021	30	43	operating	operate	VERB
biomedich-1021	30	44	system	system	NOUN
biomedich-1021	30	45	.	.	PUNCT
biomedich-1021	31	1	the	the	DET
biomedich-1021	31	2	software	software	NOUN
biomedich-1021	31	3	suite	suite	NOUN
biomedich-1021	31	4	included	include	VERB
biomedich-1021	31	5	autodock	autodock	NOUN
biomedich-1021	31	6	tools	tool	NOUN
biomedich-1021	31	7	1.5.7	1.5.7	NUM
biomedich-1021	31	8	,	,	PUNCT
biomedich-1021	31	9	biovia	biovia	PROPN
biomedich-1021	31	10	discovery	discovery	PROPN
biomedich-1021	31	11	studio	studio	PROPN
biomedich-1021	31	12	visualizer	visualizer	PROPN
biomedich-1021	31	13	2021	2021	NUM
biomedich-1021	31	14	,	,	PUNCT
biomedich-1021	31	15	and	and	CCONJ
biomedich-1021	31	16	the	the	DET
biomedich-1021	31	17	online	online	ADJ
biomedich-1021	31	18	web	web	NOUN
biomedich-1021	31	19	servers	server	NOUN
biomedich-1021	31	20	pkcsm	pkcsm	NOUN
biomedich-1021	31	21	and	and	CCONJ
biomedich-1021	31	22	protox	protox	PROPN
biomedich-1021	31	23	-	-	PUNCT
biomedich-1021	31	24	ii	ii	NOUN
biomedich-1021	31	25	for	for	ADP
biomedich-1021	31	26	admet	admet	PROPN
biomedich-1021	31	27	predictions	prediction	NOUN
biomedich-1021	31	28	.	.	PUNCT
biomedich-1021	32	1	ligand	ligand	PROPN
biomedich-1021	32	2	preparation	preparation	NOUN
biomedich-1021	32	3	three	three	NUM
biomedich-1021	32	4	-	-	PUNCT
biomedich-1021	32	5	dimensional	dimensional	ADJ
biomedich-1021	32	6	(	(	PUNCT
biomedich-1021	32	7	3d	3d	NOUN
biomedich-1021	32	8	)	)	PUNCT
biomedich-1021	32	9	structures	structure	NOUN
biomedich-1021	32	10	of	of	ADP
biomedich-1021	32	11	17	17	NUM
biomedich-1021	32	12	selected	select	VERB
biomedich-1021	32	13	bioactive	bioactive	ADJ
biomedich-1021	32	14	compounds	compound	NOUN
biomedich-1021	32	15	from	from	ADP
biomedich-1021	32	16	d.	d.	PROPN
biomedich-1021	32	17	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	32	18	and	and	CCONJ
biomedich-1021	32	19	the	the	DET
biomedich-1021	32	20	comparator	comparator	NOUN
biomedich-1021	32	21	drug	drug	NOUN
biomedich-1021	32	22	,	,	PUNCT
biomedich-1021	32	23	penicillin	penicillin	NOUN
biomedich-1021	32	24	g	g	NOUN
biomedich-1021	32	25	,	,	PUNCT
biomedich-1021	32	26	were	be	AUX
biomedich-1021	32	27	retrieved	retrieve	VERB
biomedich-1021	32	28	from	from	ADP
biomedich-1021	32	29	the	the	DET
biomedich-1021	32	30	pubchem	pubchem	NOUN
biomedich-1021	32	31	database	database	NOUN
biomedich-1021	32	32	(	(	PUNCT
biomedich-1021	32	33	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
biomedich-1021	32	34	)	)	PUNCT
biomedich-1021	32	35	in	in	ADP
biomedich-1021	32	36	.sdf	.sdf	PROPN
biomedich-1021	32	37	format	format	NOUN
biomedich-1021	32	38	.	.	PUNCT
biomedich-1021	33	1	the	the	DET
biomedich-1021	33	2	structures	structure	NOUN
biomedich-1021	33	3	were	be	AUX
biomedich-1021	33	4	then	then	ADV
biomedich-1021	33	5	imported	import	VERB
biomedich-1021	33	6	into	into	ADP
biomedich-1021	33	7	biovia	biovia	PROPN
biomedich-1021	33	8	discovery	discovery	PROPN
biomedich-1021	33	9	studio	studio	PROPN
biomedich-1021	33	10	visualizer	visualizer	PROPN
biomedich-1021	33	11	2021	2021	NUM
biomedich-1021	33	12	,	,	PUNCT
biomedich-1021	33	13	processed	process	VERB
biomedich-1021	33	14	,	,	PUNCT
biomedich-1021	33	15	and	and	CCONJ
biomedich-1021	33	16	saved	save	VERB
biomedich-1021	33	17	in	in	ADP
biomedich-1021	33	18	.pdb	.pdb	PUNCT
biomedich-1021	33	19	format	format	NOUN
biomedich-1021	33	20	for	for	ADP
biomedich-1021	33	21	further	further	ADJ
biomedich-1021	33	22	preparation	preparation	NOUN
biomedich-1021	33	23	.	.	PUNCT
biomedich-1021	34	1	target	target	NOUN
biomedich-1021	34	2	protein	protein	NOUN
biomedich-1021	34	3	preparation	preparation	NOUN
biomedich-1021	34	4	the	the	DET
biomedich-1021	34	5	3d	3d	PROPN
biomedich-1021	34	6	crystal	crystal	NOUN
biomedich-1021	34	7	structure	structure	NOUN
biomedich-1021	34	8	of	of	ADP
biomedich-1021	34	9	s.	s.	PROPN
biomedich-1021	34	10	pyogenes	pyogenes	PROPN
biomedich-1021	34	11	inosine-5'monophosphate	inosine-5'monophosphate	PROPN
biomedich-1021	34	12	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	34	13	(	(	PUNCT
biomedich-1021	34	14	impdh	impdh	NOUN
biomedich-1021	34	15	)	)	PUNCT
biomedich-1021	34	16	was	be	AUX
biomedich-1021	34	17	obtained	obtain	VERB
biomedich-1021	34	18	from	from	ADP
biomedich-1021	34	19	the	the	DET
biomedich-1021	34	20	rcsb	rcsb	ADJ
biomedich-1021	34	21	protein	protein	NOUN
biomedich-1021	34	22	data	data	PROPN
biomedich-1021	34	23	bank	bank	PROPN
biomedich-1021	34	24	(	(	PUNCT
biomedich-1021	34	25	pdb	pdb	PROPN
biomedich-1021	34	26	i	i	PROPN
biomedich-1021	34	27	d	d	PROPN
biomedich-1021	34	28	:	:	PUNCT
biomedich-1021	34	29	1zfj	1zfj	NUM
biomedich-1021	34	30	)	)	PUNCT
biomedich-1021	34	31	.	.	PUNCT
biomedich-1021	35	1	the	the	DET
biomedich-1021	35	2	protein	protein	NOUN
biomedich-1021	35	3	was	be	AUX
biomedich-1021	35	4	prepared	prepare	VERB
biomedich-1021	35	5	for	for	ADP
biomedich-1021	35	6	docking	docking	NOUN
biomedich-1021	35	7	using	use	VERB
biomedich-1021	35	8	autodock	autodock	NOUN
biomedich-1021	35	9	tools	tool	NOUN
biomedich-1021	35	10	1.5.7	1.5.7	NUM
biomedich-1021	35	11	.	.	PUNCT
biomedich-1021	36	1	this	this	DET
biomedich-1021	36	2	process	process	NOUN
biomedich-1021	36	3	involved	involve	VERB
biomedich-1021	36	4	removing	remove	VERB
biomedich-1021	36	5	all	all	DET
biomedich-1021	36	6	water	water	NOUN
biomedich-1021	36	7	molecules	molecule	NOUN
biomedich-1021	36	8	and	and	CCONJ
biomedich-1021	36	9	native	native	ADJ
biomedich-1021	36	10	co	co	ADJ
biomedich-1021	36	11	-	-	ADJ
biomedich-1021	36	12	crystallized	crystallize	VERB
biomedich-1021	36	13	ligands	ligand	NOUN
biomedich-1021	36	14	,	,	PUNCT
biomedich-1021	36	15	followed	follow	VERB
biomedich-1021	36	16	by	by	ADP
biomedich-1021	36	17	the	the	DET
biomedich-1021	36	18	addition	addition	NOUN
biomedich-1021	36	19	of	of	ADP
biomedich-1021	36	20	polar	polar	ADJ
biomedich-1021	36	21	hydrogen	hydrogen	NOUN
biomedich-1021	36	22	atoms	atom	NOUN
biomedich-1021	36	23	and	and	CCONJ
biomedich-1021	36	24	kollman	kollman	NOUN
biomedich-1021	36	25	charges	charge	NOUN
biomedich-1021	36	26	to	to	ADP
biomedich-1021	36	27	the	the	DET
biomedich-1021	36	28	protein	protein	NOUN
biomedich-1021	36	29	structure	structure	NOUN
biomedich-1021	36	30	.	.	PUNCT
biomedich-1021	37	1	the	the	DET
biomedich-1021	37	2	final	final	ADJ
biomedich-1021	37	3	prepared	prepared	ADJ
biomedich-1021	37	4	receptor	receptor	NOUN
biomedich-1021	37	5	was	be	AUX
biomedich-1021	37	6	saved	save	VERB
biomedich-1021	37	7	in	in	ADP
biomedich-1021	37	8	the	the	DET
biomedich-1021	37	9	.pdbqt	.pdbqt	NOUN
biomedich-1021	37	10	file	file	NOUN
biomedich-1021	37	11	format	format	NOUN
biomedich-1021	37	12	.	.	PUNCT
biomedich-1021	38	1	physicochemical	physicochemical	ADJ
biomedich-1021	38	2	and	and	CCONJ
biomedich-1021	38	3	admet	admet	NOUN
biomedich-1021	38	4	predictions	prediction	NOUN
biomedich-1021	38	5	the	the	DET
biomedich-1021	38	6	drug	drug	NOUN
biomedich-1021	38	7	-	-	PUNCT
biomedich-1021	38	8	likeness	likeness	NOUN
biomedich-1021	38	9	of	of	ADP
biomedich-1021	38	10	each	each	DET
biomedich-1021	38	11	compound	compound	NOUN
biomedich-1021	38	12	was	be	AUX
biomedich-1021	38	13	evaluated	evaluate	VERB
biomedich-1021	38	14	based	base	VERB
biomedich-1021	38	15	on	on	ADP
biomedich-1021	38	16	lipinski	lipinski	PROPN
biomedich-1021	38	17	’s	’s	PART
biomedich-1021	38	18	rule	rule	NOUN
biomedich-1021	38	19	of	of	ADP
biomedich-1021	38	20	five	five	NUM
biomedich-1021	38	21	(	(	PUNCT
biomedich-1021	38	22	molecular	molecular	ADJ
biomedich-1021	38	23	weight	weight	NOUN
biomedich-1021	38	24	≤	≤	NOUN
biomedich-1021	38	25	500	500	NUM
biomedich-1021	38	26	da	da	NOUN
biomedich-1021	38	27	;	;	PUNCT
biomedich-1021	38	28	log	log	VERB
biomedich-1021	38	29	p	p	NOUN
biomedich-1021	38	30	≤	≤	NUM
biomedich-1021	38	31	5	5	NUM
biomedich-1021	38	32	;	;	PUNCT
biomedich-1021	38	33	h	h	NOUN
biomedich-1021	38	34	-	-	PUNCT
biomedich-1021	38	35	bond	bond	NOUN
biomedich-1021	38	36	donors	donor	NOUN
biomedich-1021	38	37	≤	≤	ADV
biomedich-1021	38	38	5	5	NUM
biomedich-1021	38	39	;	;	PUNCT
biomedich-1021	38	40	h	h	NOUN
biomedich-1021	38	41	-	-	PUNCT
biomedich-1021	38	42	bond	bond	NOUN
biomedich-1021	38	43	acceptors	acceptor	NOUN
biomedich-1021	38	44	≤	≤	NUM
biomedich-1021	38	45	10	10	NUM
biomedich-1021	38	46	)	)	PUNCT
biomedich-1021	38	47	using	use	VERB
biomedich-1021	38	48	the	the	DET
biomedich-1021	38	49	pkcsm	pkcsm	NOUN
biomedich-1021	38	50	web	web	NOUN
biomedich-1021	38	51	server	server	NOUN
biomedich-1021	38	52	(	(	PUNCT
biomedich-1021	38	53	http://biosig.unimelb.edu.au/pkcsm/	http://biosig.unimelb.edu.au/pkcsm/	PROPN
biomedich-1021	38	54	)	)	PUNCT
biomedich-1021	38	55	.	.	PUNCT
biomedich-1021	39	1	the	the	DET
biomedich-1021	39	2	same	same	ADJ
biomedich-1021	39	3	server	server	NOUN
biomedich-1021	39	4	was	be	AUX
biomedich-1021	39	5	used	use	VERB
biomedich-1021	39	6	to	to	PART
biomedich-1021	39	7	predict	predict	VERB
biomedich-1021	39	8	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	39	9	parameters	parameter	NOUN
biomedich-1021	39	10	(	(	PUNCT
biomedich-1021	39	11	absorption	absorption	NOUN
biomedich-1021	39	12	,	,	PUNCT
biomedich-1021	39	13	distribution	distribution	NOUN
biomedich-1021	39	14	,	,	PUNCT
biomedich-1021	39	15	metabolism	metabolism	NOUN
biomedich-1021	39	16	,	,	PUNCT
biomedich-1021	39	17	excretion	excretion	NOUN
biomedich-1021	39	18	adme	adme	NOUN
biomedich-1021	39	19	)	)	PUNCT
biomedich-1021	39	20	.	.	PUNCT
biomedich-1021	40	1	toxicity	toxicity	NOUN
biomedich-1021	40	2	profiles	profile	NOUN
biomedich-1021	40	3	,	,	PUNCT
biomedich-1021	40	4	including	include	VERB
biomedich-1021	40	5	ld50	ld50	PROPN
biomedich-1021	40	6	,	,	PUNCT
biomedich-1021	40	7	ames	ame	NOUN
biomedich-1021	40	8	mutagenicity	mutagenicity	NOUN
biomedich-1021	40	9	,	,	PUNCT
biomedich-1021	40	10	and	and	CCONJ
biomedich-1021	40	11	drug	drug	NOUN
biomedich-1021	40	12	-	-	PUNCT
biomedich-1021	40	13	induced	induce	VERB
biomedich-1021	40	14	liver	liver	NOUN
biomedich-1021	40	15	injury	injury	NOUN
biomedich-1021	40	16	(	(	PUNCT
biomedich-1021	40	17	dili	dili	PROPN
biomedich-1021	40	18	)	)	PUNCT
biomedich-1021	40	19	,	,	PUNCT
biomedich-1021	40	20	were	be	AUX
biomedich-1021	40	21	predicted	predict	VERB
biomedich-1021	40	22	using	use	VERB
biomedich-1021	40	23	both	both	CCONJ
biomedich-1021	40	24	pkcsm	pkcsm	NOUN
biomedich-1021	40	25	and	and	CCONJ
biomedich-1021	40	26	the	the	DET
biomedich-1021	40	27	protox	protox	PROPN
biomedich-1021	40	28	-	-	PUNCT
biomedich-1021	40	29	ii	ii	PROPN
biomedich-1021	40	30	server	server	NOUN
biomedich-1021	40	31	(	(	PUNCT
biomedich-1021	40	32	https://tox-new.charite.de/protox_ii/	https://tox-new.charite.de/protox_ii/	NOUN
biomedich-1021	40	33	)	)	PUNCT
biomedich-1021	40	34	.	.	PUNCT
biomedich-1021	41	1	molecular	molecular	ADJ
biomedich-1021	41	2	docking	docking	NOUN
biomedich-1021	41	3	simulation	simulation	NOUN
biomedich-1021	41	4	molecular	molecular	ADJ
biomedich-1021	41	5	docking	docking	NOUN
biomedich-1021	41	6	was	be	AUX
biomedich-1021	41	7	conducted	conduct	VERB
biomedich-1021	41	8	using	use	VERB
biomedich-1021	41	9	autodock	autodock	NOUN
biomedich-1021	41	10	tools	tool	NOUN
biomedich-1021	41	11	1.5.7	1.5.7	NUM
biomedich-1021	41	12	to	to	PART
biomedich-1021	41	13	analyze	analyze	VERB
biomedich-1021	41	14	the	the	DET
biomedich-1021	41	15	binding	bind	VERB
biomedich-1021	41	16	interactions	interaction	NOUN
biomedich-1021	41	17	between	between	ADP
biomedich-1021	41	18	the	the	DET
biomedich-1021	41	19	prepared	prepare	VERB
biomedich-1021	41	20	ligands	ligand	NOUN
biomedich-1021	41	21	and	and	CCONJ
biomedich-1021	41	22	the	the	DET
biomedich-1021	41	23	impdh	impdh	NOUN
biomedich-1021	41	24	receptor	receptor	NOUN
biomedich-1021	41	25	.	.	PUNCT
biomedich-1021	42	1	a	a	DET
biomedich-1021	42	2	grid	grid	NOUN
biomedich-1021	42	3	box	box	NOUN
biomedich-1021	42	4	was	be	AUX
biomedich-1021	42	5	defined	define	VERB
biomedich-1021	42	6	to	to	PART
biomedich-1021	42	7	encompass	encompass	VERB
biomedich-1021	42	8	the	the	DET
biomedich-1021	42	9	active	active	ADJ
biomedich-1021	42	10	site	site	NOUN
biomedich-1021	42	11	of	of	ADP
biomedich-1021	42	12	the	the	DET
biomedich-1021	42	13	enzyme	enzyme	NOUN
biomedich-1021	42	14	.	.	PUNCT
biomedich-1021	43	1	the	the	DET
biomedich-1021	43	2	docking	docking	NOUN
biomedich-1021	43	3	simulations	simulation	NOUN
biomedich-1021	43	4	were	be	AUX
biomedich-1021	43	5	performed	perform	VERB
biomedich-1021	43	6	to	to	PART
biomedich-1021	43	7	calculate	calculate	VERB
biomedich-1021	43	8	the	the	DET
biomedich-1021	43	9	binding	bind	VERB
biomedich-1021	43	10	affinity	affinity	NOUN
biomedich-1021	43	11	(	(	PUNCT
biomedich-1021	43	12	δg	δg	VERB
biomedich-1021	43	13	,	,	PUNCT
biomedich-1021	43	14	in	in	ADP
biomedich-1021	43	15	kcal	kcal	PROPN
biomedich-1021	43	16	/	/	SYM
biomedich-1021	43	17	mol	mol	NOUN
biomedich-1021	43	18	)	)	PUNCT
biomedich-1021	43	19	for	for	ADP
biomedich-1021	43	20	each	each	DET
biomedich-1021	43	21	ligand	ligand	NOUN
biomedich-1021	43	22	,	,	PUNCT
biomedich-1021	43	23	and	and	CCONJ
biomedich-1021	43	24	the	the	DET
biomedich-1021	43	25	lowest	low	ADJ
biomedich-1021	43	26	energy	energy	NOUN
biomedich-1021	43	27	conformation	conformation	NOUN
biomedich-1021	43	28	was	be	AUX
biomedich-1021	43	29	selected	select	VERB
biomedich-1021	43	30	for	for	ADP
biomedich-1021	43	31	further	further	ADJ
biomedich-1021	43	32	analysis	analysis	NOUN
biomedich-1021	43	33	.	.	PUNCT
biomedich-1021	44	1	interaction	interaction	NOUN
biomedich-1021	44	2	visualization	visualization	NOUN
biomedich-1021	44	3	and	and	CCONJ
biomedich-1021	44	4	analysis	analysis	NOUN
biomedich-1021	44	5	post	post	ADJ
biomedich-1021	44	6	-	-	ADJ
biomedich-1021	44	7	docking	docking	ADJ
biomedich-1021	44	8	analysis	analysis	NOUN
biomedich-1021	44	9	was	be	AUX
biomedich-1021	44	10	performed	perform	VERB
biomedich-1021	44	11	using	use	VERB
biomedich-1021	44	12	biovia	biovia	PROPN
biomedich-1021	44	13	discovery	discovery	PROPN
biomedich-1021	44	14	studio	studio	PROPN
biomedich-1021	44	15	visualizer	visualizer	PROPN
biomedich-1021	44	16	2021	2021	NUM
biomedich-1021	44	17	.	.	PUNCT
biomedich-1021	45	1	the	the	DET
biomedich-1021	45	2	2d	2d	PROPN
biomedich-1021	45	3	and	and	CCONJ
biomedich-1021	45	4	3d	3d	NUM
biomedich-1021	45	5	interaction	interaction	NOUN
biomedich-1021	45	6	diagrams	diagram	NOUN
biomedich-1021	45	7	were	be	AUX
biomedich-1021	45	8	generated	generate	VERB
biomedich-1021	45	9	to	to	PART
biomedich-1021	45	10	identify	identify	VERB
biomedich-1021	45	11	the	the	DET
biomedich-1021	45	12	specific	specific	ADJ
biomedich-1021	45	13	amino	amino	NOUN
biomedich-1021	45	14	acid	acid	NOUN
biomedich-1021	45	15	residues	residue	NOUN
biomedich-1021	45	16	involved	involve	VERB
biomedich-1021	45	17	in	in	ADP
biomedich-1021	45	18	binding	bind	VERB
biomedich-1021	45	19	and	and	CCONJ
biomedich-1021	45	20	to	to	PART
biomedich-1021	45	21	characterize	characterize	VERB
biomedich-1021	45	22	the	the	DET
biomedich-1021	45	23	nature	nature	NOUN
biomedich-1021	45	24	of	of	ADP
biomedich-1021	45	25	the	the	DET
biomedich-1021	45	26	molecular	molecular	ADJ
biomedich-1021	45	27	interactions	interaction	NOUN
biomedich-1021	45	28	(	(	PUNCT
biomedich-1021	45	29	e.g.	e.g.	ADV
biomedich-1021	45	30	,	,	PUNCT
biomedich-1021	45	31	hydrogen	hydrogen	NOUN
biomedich-1021	45	32	bonds	bond	NOUN
biomedich-1021	45	33	,	,	PUNCT
biomedich-1021	45	34	hydrophobic	hydrophobic	NOUN
biomedich-1021	45	35	contacts	contact	NOUN
biomedich-1021	45	36	,	,	PUNCT
biomedich-1021	45	37	pi	pi	NOUN
biomedich-1021	45	38	-	-	PUNCT
biomedich-1021	45	39	interactions	interaction	NOUN
biomedich-1021	45	40	)	)	PUNCT
biomedich-1021	45	41	.	.	PUNCT
biomedich-1021	46	1	results	result	NOUN
biomedich-1021	46	2	and	and	CCONJ
biomedich-1021	46	3	discussion	discussion	NOUN
biomedich-1021	46	4	physicochemical	physicochemical	ADJ
biomedich-1021	46	5	property	property	NOUN
biomedich-1021	46	6	analysis	analysis	NOUN
biomedich-1021	46	7	and	and	CCONJ
biomedich-1021	46	8	candidate	candidate	NOUN
biomedich-1021	46	9	filtering	filter	VERB
biomedich-1021	46	10	the	the	DET
biomedich-1021	46	11	initial	initial	ADJ
biomedich-1021	46	12	step	step	NOUN
biomedich-1021	46	13	in	in	ADP
biomedich-1021	46	14	our	our	PRON
biomedich-1021	46	15	virtual	virtual	ADJ
biomedich-1021	46	16	screening	screening	NOUN
biomedich-1021	46	17	workflow	workflow	NOUN
biomedich-1021	46	18	involved	involve	VERB
biomedich-1021	46	19	assessing	assess	VERB
biomedich-1021	46	20	the	the	DET
biomedich-1021	46	21	drug	drug	NOUN
biomedich-1021	46	22	-	-	PUNCT
biomedich-1021	46	23	likeness	likeness	NOUN
biomedich-1021	46	24	of	of	ADP
biomedich-1021	46	25	the	the	DET
biomedich-1021	46	26	17	17	NUM
biomedich-1021	46	27	compounds	compound	NOUN
biomedich-1021	46	28	based	base	VERB
biomedich-1021	46	29	on	on	ADP
biomedich-1021	46	30	lipinski	lipinski	PROPN
biomedich-1021	46	31	’s	’s	PART
biomedich-1021	46	32	rule	rule	NOUN
biomedich-1021	46	33	of	of	ADP
biomedich-1021	46	34	five	five	NUM
biomedich-1021	46	35	to	to	PART
biomedich-1021	46	36	prioritize	prioritize	VERB
biomedich-1021	46	37	candidates	candidate	NOUN
biomedich-1021	46	38	with	with	ADP
biomedich-1021	46	39	a	a	DET
biomedich-1021	46	40	higher	high	ADJ
biomedich-1021	46	41	probability	probability	NOUN
biomedich-1021	46	42	of	of	ADP
biomedich-1021	46	43	oral	oral	ADJ
biomedich-1021	46	44	bioavailability	bioavailability	NOUN
biomedich-1021	46	45	(	(	PUNCT
biomedich-1021	46	46	lipinski	lipinski	PROPN
biomedich-1021	46	47	et	et	PROPN
biomedich-1021	46	48	al	al	PROPN
biomedich-1021	46	49	.	.	PROPN
biomedich-1021	46	50	,	,	PUNCT
biomedich-1021	46	51	2001	2001	NUM
biomedich-1021	46	52	)	)	PUNCT
biomedich-1021	46	53	.	.	PUNCT
biomedich-1021	47	1	as	as	SCONJ
biomedich-1021	47	2	detailed	detailed	ADJ
biomedich-1021	47	3	in	in	ADP
biomedich-1021	47	4	table	table	NOUN
biomedich-1021	47	5	1	1	NUM
biomedich-1021	47	6	,	,	PUNCT
biomedich-1021	47	7	this	this	DET
biomedich-1021	47	8	analysis	analysis	NOUN
biomedich-1021	47	9	served	serve	VERB
biomedich-1021	47	10	as	as	ADP
biomedich-1021	47	11	a	a	DET
biomedich-1021	47	12	critical	critical	ADJ
biomedich-1021	47	13	filter	filter	NOUN
biomedich-1021	47	14	.	.	PUNCT
biomedich-1021	48	1	six	six	NUM
biomedich-1021	48	2	compounds	compound	NOUN
biomedich-1021	48	3	(	(	PUNCT
biomedich-1021	48	4	cochinchinenin	cochinchinenin	ADJ
biomedich-1021	48	5	,	,	PUNCT
biomedich-1021	48	6	(	(	PUNCT
biomedich-1021	48	7	2r)-8methylsocotrin-4'-ol	2r)-8methylsocotrin-4'-ol	NOUN
biomedich-1021	48	8	,	,	PUNCT
biomedich-1021	48	9	cochinchinenene	cochinchinenene	VERB
biomedich-1021	48	10	a	a	DET
biomedich-1021	48	11	,	,	PUNCT
biomedich-1021	48	12	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	48	13	b	b	NOUN
biomedich-1021	48	14	,	,	PUNCT
biomedich-1021	48	15	cochinchinenin	cochinchinenin	NOUN
biomedich-1021	48	16	b	b	NOUN
biomedich-1021	48	17	,	,	PUNCT
biomedich-1021	48	18	and	and	CCONJ
biomedich-1021	48	19	cochinchinenin	cochinchinenin	ADJ
biomedich-1021	48	20	c	c	NOUN
biomedich-1021	48	21	)	)	PUNCT
biomedich-1021	48	22	were	be	AUX
biomedich-1021	48	23	found	find	VERB
biomedich-1021	48	24	to	to	PART
biomedich-1021	48	25	violate	violate	VERB
biomedich-1021	48	26	two	two	NUM
biomedich-1021	48	27	or	or	CCONJ
biomedich-1021	48	28	more	more	ADJ
biomedich-1021	48	29	of	of	ADP
biomedich-1021	48	30	lipinski	lipinski	PROPN
biomedich-1021	48	31	's	's	PART
biomedich-1021	48	32	rules	rule	NOUN
biomedich-1021	48	33	.	.	PUNCT
biomedich-1021	49	1	significant	significant	ADJ
biomedich-1021	49	2	deviations	deviation	NOUN
biomedich-1021	49	3	,	,	PUNCT
biomedich-1021	49	4	particularly	particularly	ADV
biomedich-1021	49	5	in	in	ADP
biomedich-1021	49	6	molecular	molecular	ADJ
biomedich-1021	49	7	weight	weight	NOUN
biomedich-1021	49	8	(	(	PUNCT
biomedich-1021	49	9	mw	mw	X
biomedich-1021	49	10	>	>	X
biomedich-1021	49	11	500	500	NUM
biomedich-1021	49	12	da	da	NOUN
biomedich-1021	49	13	)	)	PUNCT
biomedich-1021	49	14	and	and	CCONJ
biomedich-1021	49	15	lipophilicity	lipophilicity	NOUN
biomedich-1021	49	16	(	(	PUNCT
biomedich-1021	49	17	logp	logp	NOUN
biomedich-1021	49	18	>	>	X
biomedich-1021	49	19	5	5	NUM
biomedich-1021	49	20	)	)	PUNCT
biomedich-1021	49	21	,	,	PUNCT
biomedich-1021	49	22	are	be	AUX
biomedich-1021	49	23	strongly	strongly	ADV
biomedich-1021	49	24	correlated	correlate	VERB
biomedich-1021	49	25	with	with	ADP
biomedich-1021	49	26	poor	poor	ADJ
biomedich-1021	49	27	absorption	absorption	NOUN
biomedich-1021	49	28	and	and	CCONJ
biomedich-1021	49	29	permeability	permeability	NOUN
biomedich-1021	49	30	,	,	PUNCT
biomedich-1021	49	31	making	make	VERB
biomedich-1021	49	32	them	they	PRON
biomedich-1021	49	33	less	less	ADV
biomedich-1021	49	34	desirable	desirable	ADJ
biomedich-1021	49	35	as	as	ADP
biomedich-1021	49	36	oral	oral	ADJ
biomedich-1021	49	37	drug	drug	NOUN
biomedich-1021	49	38	candidates	candidate	NOUN
biomedich-1021	49	39	(	(	PUNCT
biomedich-1021	49	40	egbert	egbert	PROPN
biomedich-1021	49	41	et	et	PROPN
biomedich-1021	49	42	al	al	PROPN
biomedich-1021	49	43	.	.	PROPN
biomedich-1021	49	44	,	,	PUNCT
biomedich-1021	49	45	2019	2019	NUM
biomedich-1021	49	46	;	;	PUNCT
biomedich-1021	49	47	nhlapho	nhlapho	NOUN
biomedich-1021	49	48	et	et	NOUN
biomedich-1021	49	49	al	al	PROPN
biomedich-1021	49	50	.	.	PROPN
biomedich-1021	49	51	,	,	PUNCT
biomedich-1021	49	52	2024	2024	NUM
biomedich-1021	49	53	)	)	PUNCT
biomedich-1021	49	54	.	.	PUNCT
biomedich-1021	50	1	consequently	consequently	ADV
biomedich-1021	50	2	,	,	PUNCT
biomedich-1021	50	3	these	these	DET
biomedich-1021	50	4	six	six	NUM
biomedich-1021	50	5	compounds	compound	NOUN
biomedich-1021	50	6	were	be	AUX
biomedich-1021	50	7	excluded	exclude	VERB
biomedich-1021	50	8	from	from	ADP
biomedich-1021	50	9	further	further	ADJ
biomedich-1021	50	10	investigation	investigation	NOUN
biomedich-1021	50	11	.	.	PUNCT
biomedich-1021	51	1	the	the	DET
biomedich-1021	51	2	remaining	remain	VERB
biomedich-1021	51	3	11	11	NUM
biomedich-1021	51	4	compounds	compound	NOUN
biomedich-1021	51	5	,	,	PUNCT
biomedich-1021	51	6	which	which	PRON
biomedich-1021	51	7	either	either	CCONJ
biomedich-1021	51	8	fully	fully	ADV
biomedich-1021	51	9	complied	comply	VERB
biomedich-1021	51	10	with	with	ADP
biomedich-1021	51	11	the	the	DET
biomedich-1021	51	12	rules	rule	NOUN
biomedich-1021	51	13	or	or	CCONJ
biomedich-1021	51	14	had	have	VERB
biomedich-1021	51	15	only	only	ADV
biomedich-1021	51	16	a	a	DET
biomedich-1021	51	17	single	single	ADJ
biomedich-1021	51	18	violation	violation	NOUN
biomedich-1021	51	19	,	,	PUNCT
biomedich-1021	51	20	were	be	AUX
biomedich-1021	51	21	deemed	deem	VERB
biomedich-1021	51	22	promising	promising	ADJ
biomedich-1021	51	23	and	and	CCONJ
biomedich-1021	51	24	advanced	advanced	ADJ
biomedich-1021	51	25	to	to	ADP
biomedich-1021	51	26	the	the	DET
biomedich-1021	51	27	subsequent	subsequent	ADJ
biomedich-1021	51	28	stages	stage	NOUN
biomedich-1021	51	29	of	of	ADP
biomedich-1021	51	30	the	the	DET
biomedich-1021	51	31	analysis	analysis	NOUN
biomedich-1021	51	32	.	.	PUNCT
biomedich-1021	52	1	this	this	DET
biomedich-1021	52	2	filtered	filter	VERB
biomedich-1021	52	3	set	set	NOUN
biomedich-1021	52	4	of	of	ADP
biomedich-1021	52	5	candidates	candidate	NOUN
biomedich-1021	52	6	is	be	AUX
biomedich-1021	52	7	predicted	predict	VERB
biomedich-1021	52	8	to	to	PART
biomedich-1021	52	9	possess	possess	VERB
biomedich-1021	52	10	more	more	ADV
biomedich-1021	52	11	favorable	favorable	ADJ
biomedich-1021	52	12	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	52	13	properties	property	NOUN
biomedich-1021	52	14	.	.	PUNCT
biomedich-1021	53	1	handayani	handayani	PROPN
biomedich-1021	53	2	et	et	PROPN
biomedich-1021	53	3	al	al	PROPN
biomedich-1021	53	4	.	.	PROPN
biomedich-1021	53	5	–	–	PUNCT
biomedich-1021	53	6	in	in	ADP
biomedich-1021	53	7	silico	silico	NOUN
biomedich-1021	53	8	inhibition	inhibition	NOUN
biomedich-1021	53	9	of	of	ADP
biomedich-1021	53	10	s.	s.	PROPN
biomedich-1021	53	11	pyogenes	pyogenes	PROPN
biomedich-1021	53	12	impdh	impdh	NOUN
biomedich-1021	53	13	1267	1267	NUM
biomedich-1021	53	14	table	table	NOUN
biomedich-1021	53	15	1	1	NUM
biomedich-1021	53	16	.	.	PUNCT
biomedich-1021	53	17	physicochemical	physicochemical	ADJ
biomedich-1021	53	18	property	property	NOUN
biomedich-1021	53	19	prediction	prediction	NOUN
biomedich-1021	53	20	of	of	ADP
biomedich-1021	53	21	compounds	compound	NOUN
biomedich-1021	53	22	from	from	ADP
biomedich-1021	53	23	d.	d.	PROPN
biomedich-1021	53	24	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	53	25	based	base	VERB
biomedich-1021	53	26	on	on	ADP
biomedich-1021	53	27	lipinski	lipinski	PROPN
biomedich-1021	53	28	's	's	PART
biomedich-1021	53	29	rule	rule	NOUN
biomedich-1021	53	30	of	of	ADP
biomedich-1021	53	31	five	five	NUM
biomedich-1021	53	32	.	.	PUNCT
biomedich-1021	54	1	no	no	DET
biomedich-1021	54	2	compound	compound	NOUN
biomedich-1021	54	3	name	name	NOUN
biomedich-1021	54	4	parameters	parameter	NOUN
biomedich-1021	54	5	of	of	ADP
biomedich-1021	54	6	lipinski	lipinski	PROPN
biomedich-1021	54	7	's	's	PART
biomedich-1021	54	8	law	law	NOUN
biomedich-1021	54	9	of	of	ADP
biomedich-1021	54	10	five	five	NUM
biomedich-1021	54	11	application	application	NOUN
biomedich-1021	54	12	of	of	ADP
biomedich-1021	54	13	lipinski	lipinski	PROPN
biomedich-1021	54	14	's	's	PART
biomedich-1021	54	15	law	law	NOUN
biomedich-1021	54	16	of	of	ADP
biomedich-1021	54	17	five	five	NUM
biomedich-1021	54	18	mw	mw	NOUN
biomedich-1021	54	19	(	(	PUNCT
biomedich-1021	54	20	g	g	NOUN
biomedich-1021	54	21	/	/	SYM
biomedich-1021	54	22	mol	mol	NOUN
biomedich-1021	54	23	)	)	PUNCT
biomedich-1021	54	24	log	log	NOUN
biomedich-1021	54	25	p	p	PROPN
biomedich-1021	54	26	hba	hba	PROPN
biomedich-1021	54	27	hbd	hbd	PROPN
biomedich-1021	54	28	1	1	NUM
biomedich-1021	54	29	isopimaric	isopimaric	NOUN
biomedich-1021	54	30	acid	acid	NOUN
biomedich-1021	54	31	302.458	302.458	NUM
biomedich-1021	54	32	5.206	5.206	NUM
biomedich-1021	54	33	2	2	NUM
biomedich-1021	54	34	1	1	NUM
biomedich-1021	54	35	violate	violate	VERB
biomedich-1021	54	36	the	the	DET
biomedich-1021	54	37	lipinski	lipinski	PROPN
biomedich-1021	54	38	's	's	PART
biomedich-1021	54	39	ro5	ro5	ADJ
biomedich-1021	54	40	(	(	PUNCT
biomedich-1021	54	41	1	1	NUM
biomedich-1021	54	42	time	time	NOUN
biomedich-1021	54	43	)	)	PUNCT
biomedich-1021	54	44	2	2	NUM
biomedich-1021	54	45	2'-o	2'-o	NUM
biomedich-1021	54	46	methylisoliquiritigenin	methylisoliquiritigenin	NOUN
biomedich-1021	54	47	270.284	270.284	NUM
biomedich-1021	54	48	3.003	3.003	NUM
biomedich-1021	54	49	4	4	NUM
biomedich-1021	54	50	2	2	NUM
biomedich-1021	54	51	respect	respect	NOUN
biomedich-1021	54	52	the	the	DET
biomedich-1021	54	53	lipinski	lipinski	PROPN
biomedich-1021	54	54	's	's	PART
biomedich-1021	54	55	ro5	ro5	ADJ
biomedich-1021	54	56	3	3	NUM
biomedich-1021	54	57	loureirin	loureirin	NOUN
biomedich-1021	54	58	a	a	DET
biomedich-1021	54	59	286.327	286.327	NUM
biomedich-1021	54	60	3.225	3.225	NUM
biomedich-1021	54	61	4	4	NUM
biomedich-1021	54	62	1	1	NUM
biomedich-1021	54	63	respect	respect	NOUN
biomedich-1021	54	64	the	the	DET
biomedich-1021	54	65	lipinski	lipinski	PROPN
biomedich-1021	54	66	's	's	PART
biomedich-1021	54	67	ro5	ro5	ADJ
biomedich-1021	54	68	4	4	NUM
biomedich-1021	54	69	davidigenin	davidigenin	ADJ
biomedich-1021	54	70	258.273	258.273	NUM
biomedich-1021	54	71	2.619	2.619	NUM
biomedich-1021	54	72	4	4	NUM
biomedich-1021	54	73	3	3	NUM
biomedich-1021	54	74	respect	respect	NOUN
biomedich-1021	54	75	the	the	DET
biomedich-1021	54	76	lipinski	lipinski	PROPN
biomedich-1021	54	77	's	's	PART
biomedich-1021	54	78	ro5	ro5	ADJ
biomedich-1021	54	79	5	5	NUM
biomedich-1021	54	80	4'-hydroxy-2,6	4'-hydroxy-2,6	NUM
biomedich-1021	54	81	-	-	PUNCT
biomedich-1021	54	82	dimethoxydihydrochalcone	dimethoxydihydrochalcone	VERB
biomedich-1021	54	83	286.327	286.327	NUM
biomedich-1021	54	84	3.225	3.225	NUM
biomedich-1021	54	85	4	4	NUM
biomedich-1021	54	86	1	1	NUM
biomedich-1021	54	87	respect	respect	NOUN
biomedich-1021	54	88	the	the	DET
biomedich-1021	54	89	lipinski	lipinski	PROPN
biomedich-1021	54	90	's	's	PART
biomedich-1021	54	91	ro5	ro5	ADJ
biomedich-1021	54	92	6	6	NUM
biomedich-1021	54	93	4,4'-dihydroxy-2,6dimethoxydihydrochalcone	4,4'-dihydroxy-2,6dimethoxydihydrochalcone	NUM
biomedich-1021	54	94	302.326	302.326	NUM
biomedich-1021	54	95	2.931	2.931	NUM
biomedich-1021	54	96	5	5	NUM
biomedich-1021	54	97	2	2	NUM
biomedich-1021	54	98	respect	respect	NOUN
biomedich-1021	54	99	the	the	DET
biomedich-1021	54	100	lipinski	lipinski	PROPN
biomedich-1021	54	101	's	's	PART
biomedich-1021	54	102	ro5	ro5	ADJ
biomedich-1021	54	103	7	7	NUM
biomedich-1021	54	104	cochinchinenin	cochinchinenin	ADJ
biomedich-1021	54	105	514.574	514.574	NUM
biomedich-1021	54	106	5.803	5.803	NUM
biomedich-1021	54	107	7	7	NUM
biomedich-1021	54	108	5	5	NUM
biomedich-1021	54	109	violate	violate	VERB
biomedich-1021	54	110	the	the	DET
biomedich-1021	54	111	lipinski	lipinski	PROPN
biomedich-1021	54	112	's	's	PART
biomedich-1021	54	113	ro5	ro5	ADJ
biomedich-1021	54	114	(	(	PUNCT
biomedich-1021	54	115	2	2	NUM
biomedich-1021	54	116	times	time	NOUN
biomedich-1021	54	117	)	)	PUNCT
biomedich-1021	54	118	8	8	NUM
biomedich-1021	54	119	(	(	PUNCT
biomedich-1021	54	120	2r)-8	2r)-8	NUM
biomedich-1021	54	121	-	-	PUNCT
biomedich-1021	54	122	methylsocotrin-4'-ol	methylsocotrin-4'-ol	NOUN
biomedich-1021	54	123	512.602	512.602	NUM
biomedich-1021	54	124	6.657	6.657	NUM
biomedich-1021	54	125	6	6	NUM
biomedich-1021	54	126	4	4	NUM
biomedich-1021	54	127	violate	violate	VERB
biomedich-1021	54	128	the	the	DET
biomedich-1021	54	129	lipinski	lipinski	PROPN
biomedich-1021	54	130	's	's	PART
biomedich-1021	54	131	ro5	ro5	ADJ
biomedich-1021	54	132	(	(	PUNCT
biomedich-1021	54	133	2	2	NUM
biomedich-1021	54	134	times	time	NOUN
biomedich-1021	54	135	)	)	PUNCT
biomedich-1021	54	136	9	9	NUM
biomedich-1021	54	137	diphenolic	diphenolic	NOUN
biomedich-1021	54	138	acid	acid	NOUN
biomedich-1021	54	139	286.327	286.327	NUM
biomedich-1021	54	140	3.269	3.269	NUM
biomedich-1021	54	141	4	4	NUM
biomedich-1021	54	142	3	3	NUM
biomedich-1021	54	143	respect	respect	NOUN
biomedich-1021	54	144	the	the	DET
biomedich-1021	54	145	lipinski	lipinski	PROPN
biomedich-1021	54	146	's	's	PART
biomedich-1021	54	147	ro5	ro5	ADJ
biomedich-1021	54	148	10	10	NUM
biomedich-1021	54	149	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	54	150	a	a	DET
biomedich-1021	54	151	526.629	526.629	NUM
biomedich-1021	54	152	7.067	7.067	NUM
biomedich-1021	54	153	6	6	NUM
biomedich-1021	54	154	2	2	NUM
biomedich-1021	54	155	violate	violate	VERB
biomedich-1021	54	156	the	the	DET
biomedich-1021	54	157	lipinski	lipinski	PROPN
biomedich-1021	54	158	's	's	PART
biomedich-1021	54	159	ro5	ro5	ADJ
biomedich-1021	54	160	(	(	PUNCT
biomedich-1021	54	161	2	2	NUM
biomedich-1021	54	162	times	time	NOUN
biomedich-1021	54	163	)	)	PUNCT
biomedich-1021	54	164	11	11	NUM
biomedich-1021	54	165	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	54	166	b	b	NOUN
biomedich-1021	54	167	512.602	512.602	NUM
biomedich-1021	54	168	6.764	6.764	NUM
biomedich-1021	54	169	6	6	NUM
biomedich-1021	54	170	3	3	NUM
biomedich-1021	54	171	violate	violate	VERB
biomedich-1021	54	172	the	the	DET
biomedich-1021	54	173	lipinski	lipinski	PROPN
biomedich-1021	54	174	's	's	PART
biomedich-1021	54	175	ro5	ro5	ADJ
biomedich-1021	54	176	(	(	PUNCT
biomedich-1021	54	177	2	2	NUM
biomedich-1021	54	178	times	time	NOUN
biomedich-1021	54	179	)	)	PUNCT
biomedich-1021	54	180	12	12	NUM
biomedich-1021	54	181	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	54	182	c	c	PROPN
biomedich-1021	54	183	498.575	498.575	NUM
biomedich-1021	54	184	6.461	6.461	NUM
biomedich-1021	54	185	6	6	NUM
biomedich-1021	54	186	4	4	NUM
biomedich-1021	54	187	violate	violate	VERB
biomedich-1021	54	188	the	the	DET
biomedich-1021	54	189	lipinski	lipinski	PROPN
biomedich-1021	54	190	's	's	PART
biomedich-1021	54	191	ro5	ro5	ADJ
biomedich-1021	54	192	(	(	PUNCT
biomedich-1021	54	193	1	1	NUM
biomedich-1021	54	194	time	time	NOUN
biomedich-1021	54	195	)	)	PUNCT
biomedich-1021	54	196	13	13	NUM
biomedich-1021	54	197	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	55	1	d	d	X
biomedich-1021	55	2	484.548	484.548	NUM
biomedich-1021	55	3	5.515	5.515	NUM
biomedich-1021	55	4	6	6	NUM
biomedich-1021	55	5	4	4	NUM
biomedich-1021	55	6	violate	violate	VERB
biomedich-1021	55	7	the	the	DET
biomedich-1021	55	8	lipinski	lipinski	PROPN
biomedich-1021	55	9	's	's	PART
biomedich-1021	55	10	ro5	ro5	ADJ
biomedich-1021	55	11	(	(	PUNCT
biomedich-1021	55	12	1	1	NUM
biomedich-1021	55	13	time	time	NOUN
biomedich-1021	55	14	)	)	PUNCT
biomedich-1021	55	15	14	14	NUM
biomedich-1021	55	16	cochinchinenin	cochinchinenin	NOUN
biomedich-1021	55	17	b	b	PROPN
biomedich-1021	55	18	542.628	542.628	NUM
biomedich-1021	55	19	6.409	6.409	NUM
biomedich-1021	55	20	7	7	NUM
biomedich-1021	55	21	3	3	NUM
biomedich-1021	55	22	violate	violate	VERB
biomedich-1021	55	23	the	the	DET
biomedich-1021	55	24	lipinski	lipinski	PROPN
biomedich-1021	55	25	's	's	PART
biomedich-1021	55	26	ro5	ro5	ADJ
biomedich-1021	55	27	(	(	PUNCT
biomedich-1021	55	28	2	2	NUM
biomedich-1021	55	29	times	time	NOUN
biomedich-1021	55	30	)	)	PUNCT
biomedich-1021	55	31	15	15	NUM
biomedich-1021	55	32	cochinchinenin	cochinchinenin	NOUN
biomedich-1021	55	33	c	c	NOUN
biomedich-1021	55	34	542.628	542.628	NUM
biomedich-1021	55	35	6.409	6.409	NUM
biomedich-1021	55	36	7	7	NUM
biomedich-1021	55	37	3	3	NUM
biomedich-1021	55	38	violate	violate	VERB
biomedich-1021	55	39	the	the	DET
biomedich-1021	55	40	lipinski	lipinski	PROPN
biomedich-1021	55	41	's	's	PART
biomedich-1021	55	42	ro5	ro5	ADJ
biomedich-1021	55	43	(	(	PUNCT
biomedich-1021	55	44	2	2	NUM
biomedich-1021	55	45	times	time	NOUN
biomedich-1021	55	46	)	)	PUNCT
biomedich-1021	55	47	16	16	NUM
biomedich-1021	55	48	trans-3,5	trans-3,5	PROPN
biomedich-1021	55	49	-	-	PUNCT
biomedich-1021	55	50	dihydroxy-4'-methoxystilbene	dihydroxy-4'-methoxystilbene	VERB
biomedich-1021	55	51	242.274	242.274	NUM
biomedich-1021	55	52	3.277	3.277	NUM
biomedich-1021	55	53	3	3	NUM
biomedich-1021	55	54	2	2	NUM
biomedich-1021	55	55	respect	respect	NOUN
biomedich-1021	55	56	the	the	DET
biomedich-1021	55	57	lipinski	lipinski	PROPN
biomedich-1021	55	58	's	's	PART
biomedich-1021	55	59	ro5	ro5	ADJ
biomedich-1021	55	60	17	17	NUM
biomedich-1021	55	61	(	(	PUNCT
biomedich-1021	55	62	2s)-5	2s)-5	NUM
biomedich-1021	55	63	-	-	PUNCT
biomedich-1021	55	64	methoxy-6	methoxy-6	NUM
biomedich-1021	55	65	-	-	PUNCT
biomedich-1021	55	66	methylflavan-7	methylflavan-7	NOUN
biomedich-1021	55	67	-	-	PUNCT
biomedich-1021	55	68	ol	ol	ADJ
biomedich-1021	55	69	270.328	270.328	NUM
biomedich-1021	55	70	3.776	3.776	NUM
biomedich-1021	55	71	3	3	NUM
biomedich-1021	55	72	1	1	NUM
biomedich-1021	55	73	respect	respect	NOUN
biomedich-1021	55	74	the	the	DET
biomedich-1021	55	75	lipinski	lipinski	PROPN
biomedich-1021	55	76	's	's	PART
biomedich-1021	55	77	ro5	ro5	ADJ
biomedich-1021	55	78	18	18	NUM
biomedich-1021	55	79	penicillin	penicillin	NOUN
biomedich-1021	55	80	g	g	PROPN
biomedich-1021	55	81	334.397	334.397	NUM
biomedich-1021	55	82	0.861	0.861	NUM
biomedich-1021	55	83	6	6	NUM
biomedich-1021	55	84	2	2	NUM
biomedich-1021	55	85	respect	respect	NOUN
biomedich-1021	55	86	the	the	DET
biomedich-1021	55	87	lipinski	lipinski	PROPN
biomedich-1021	55	88	's	's	PART
biomedich-1021	55	89	ro5	ro5	ADJ
biomedich-1021	55	90	molecular	molecular	ADJ
biomedich-1021	55	91	docking	docking	NOUN
biomedich-1021	55	92	and	and	CCONJ
biomedich-1021	55	93	binding	bind	VERB
biomedich-1021	55	94	affinity	affinity	NOUN
biomedich-1021	55	95	of	of	ADP
biomedich-1021	55	96	filtered	filter	VERB
biomedich-1021	55	97	candidates	candidate	NOUN
biomedich-1021	55	98	the	the	DET
biomedich-1021	55	99	11	11	NUM
biomedich-1021	55	100	compounds	compound	NOUN
biomedich-1021	55	101	that	that	PRON
biomedich-1021	55	102	passed	pass	VERB
biomedich-1021	55	103	the	the	DET
biomedich-1021	55	104	physicochemical	physicochemical	ADJ
biomedich-1021	55	105	screening	screening	NOUN
biomedich-1021	55	106	were	be	AUX
biomedich-1021	55	107	docked	dock	VERB
biomedich-1021	55	108	into	into	ADP
biomedich-1021	55	109	the	the	DET
biomedich-1021	55	110	active	active	ADJ
biomedich-1021	55	111	site	site	NOUN
biomedich-1021	55	112	of	of	ADP
biomedich-1021	55	113	impdh	impdh	NOUN
biomedich-1021	55	114	(	(	PUNCT
biomedich-1021	55	115	1zfj	1zfj	NUM
biomedich-1021	55	116	)	)	PUNCT
biomedich-1021	55	117	.	.	PUNCT
biomedich-1021	56	1	the	the	DET
biomedich-1021	56	2	predicted	predict	VERB
biomedich-1021	56	3	binding	bind	VERB
biomedich-1021	56	4	affinities	affinity	NOUN
biomedich-1021	56	5	are	be	AUX
biomedich-1021	56	6	presented	present	VERB
biomedich-1021	56	7	in	in	ADP
biomedich-1021	56	8	table	table	NOUN
biomedich-1021	56	9	2	2	NUM
biomedich-1021	56	10	.	.	PUNCT
biomedich-1021	57	1	all	all	DET
biomedich-1021	57	2	candidates	candidate	NOUN
biomedich-1021	57	3	exhibited	exhibit	VERB
biomedich-1021	57	4	strong	strong	ADJ
biomedich-1021	57	5	binding	bind	VERB
biomedich-1021	57	6	energies	energy	NOUN
biomedich-1021	57	7	,	,	PUNCT
biomedich-1021	57	8	ranging	range	VERB
biomedich-1021	57	9	from	from	ADP
biomedich-1021	57	10	−6.7	−6.7	NUM
biomedich-1021	57	11	to	to	ADP
biomedich-1021	57	12	−8.2	−8.2	PROPN
biomedich-1021	57	13	kcal	kcal	PROPN
biomedich-1021	57	14	/	/	SYM
biomedich-1021	57	15	mol	mol	PROPN
biomedich-1021	57	16	.	.	PUNCT
biomedich-1021	58	1	a	a	DET
biomedich-1021	58	2	lower	low	ADJ
biomedich-1021	58	3	,	,	PUNCT
biomedich-1021	58	4	more	more	ADV
biomedich-1021	58	5	negative	negative	ADJ
biomedich-1021	58	6	binding	bind	VERB
biomedich-1021	58	7	energy	energy	NOUN
biomedich-1021	58	8	correlates	correlate	VERB
biomedich-1021	58	9	with	with	ADP
biomedich-1021	58	10	higher	high	ADJ
biomedich-1021	58	11	binding	binding	ADJ
biomedich-1021	58	12	affinity	affinity	NOUN
biomedich-1021	58	13	and	and	CCONJ
biomedich-1021	58	14	a	a	DET
biomedich-1021	58	15	more	more	ADV
biomedich-1021	58	16	stable	stable	ADJ
biomedich-1021	58	17	ligand	ligand	NOUN
biomedich-1021	58	18	-	-	PUNCT
biomedich-1021	58	19	receptor	receptor	NOUN
biomedich-1021	58	20	complex	complex	NOUN
biomedich-1021	58	21	(	(	PUNCT
biomedich-1021	58	22	buchwald	buchwald	NOUN
biomedich-1021	58	23	,	,	PUNCT
biomedich-1021	58	24	2019	2019	NUM
biomedich-1021	58	25	;	;	PUNCT
biomedich-1021	58	26	monteiro	monteiro	PROPN
biomedich-1021	58	27	et	et	PROPN
biomedich-1021	58	28	al	al	PROPN
biomedich-1021	58	29	.	.	PROPN
biomedich-1021	58	30	,	,	PUNCT
biomedich-1021	58	31	2022	2022	NUM
biomedich-1021	58	32	)	)	PUNCT
biomedich-1021	58	33	.	.	PUNCT
biomedich-1021	59	1	isopimaric	isopimaric	ADJ
biomedich-1021	59	2	acid	acid	PROPN
biomedich-1021	59	3	(	(	PUNCT
biomedich-1021	59	4	−8.2	−8.2	PROPN
biomedich-1021	59	5	kcal	kcal	PROPN
biomedich-1021	59	6	/	/	SYM
biomedich-1021	59	7	mol	mol	NOUN
biomedich-1021	59	8	)	)	PUNCT
biomedich-1021	59	9	,	,	PUNCT
biomedich-1021	59	10	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	59	11	d	d	PROPN
biomedich-1021	59	12	(	(	PUNCT
biomedich-1021	59	13	-8.1	-8.1	PROPN
biomedich-1021	59	14	kcal	kcal	PROPN
biomedich-1021	59	15	/	/	SYM
biomedich-1021	59	16	mol	mol	NOUN
biomedich-1021	59	17	)	)	PUNCT
biomedich-1021	59	18	,	,	PUNCT
biomedich-1021	59	19	and	and	CCONJ
biomedich-1021	59	20	2'-o	2'-o	NUM
biomedich-1021	59	21	methylisoliquiritigenin	methylisoliquiritigenin	ADV
biomedich-1021	59	22	(	(	PUNCT
biomedich-1021	59	23	−8.0	−8.0	PROPN
biomedich-1021	59	24	kcal	kcal	PROPN
biomedich-1021	59	25	/	/	SYM
biomedich-1021	59	26	mol	mol	PROPN
biomedich-1021	59	27	)	)	PUNCT
biomedich-1021	59	28	emerged	emerge	VERB
biomedich-1021	59	29	as	as	ADP
biomedich-1021	59	30	the	the	DET
biomedich-1021	59	31	top	top	ADJ
biomedich-1021	59	32	three	three	NUM
biomedich-1021	59	33	compounds	compound	NOUN
biomedich-1021	59	34	with	with	ADP
biomedich-1021	59	35	the	the	DET
biomedich-1021	59	36	most	most	ADV
biomedich-1021	59	37	potent	potent	ADJ
biomedich-1021	59	38	predicted	predict	VERB
biomedich-1021	59	39	binding	bind	VERB
biomedich-1021	59	40	to	to	ADP
biomedich-1021	59	41	the	the	DET
biomedich-1021	59	42	target	target	NOUN
biomedich-1021	59	43	enzyme	enzyme	NOUN
biomedich-1021	59	44	.	.	PUNCT
biomedich-1021	60	1	table	table	NOUN
biomedich-1021	60	2	2	2	NUM
biomedich-1021	60	3	.	.	PUNCT
biomedich-1021	61	1	binding	bind	VERB
biomedich-1021	61	2	affinities	affinity	NOUN
biomedich-1021	61	3	of	of	ADP
biomedich-1021	61	4	filtered	filter	VERB
biomedich-1021	61	5	compounds	compound	NOUN
biomedich-1021	61	6	against	against	ADP
biomedich-1021	61	7	impdh	impdh	NOUN
biomedich-1021	61	8	(	(	PUNCT
biomedich-1021	61	9	1zfj	1zfj	NUM
biomedich-1021	61	10	)	)	PUNCT
biomedich-1021	61	11	.	.	PUNCT
biomedich-1021	62	1	protein	protein	NOUN
biomedich-1021	62	2	-	-	PUNCT
biomedich-1021	62	3	ligand	ligand	NOUN
biomedich-1021	62	4	binding	bind	VERB
biomedich-1021	62	5	affinity	affinity	NOUN
biomedich-1021	62	6	1zfj	1zfj	NOUN
biomedich-1021	62	7	_	_	PUNCT
biomedich-1021	62	8	isopimaric	isopimaric	ADJ
biomedich-1021	62	9	acid	acid	NOUN
biomedich-1021	62	10	-8,2	-8,2	PUNCT
biomedich-1021	63	1	1zfj	1zfj	NUM
biomedich-1021	63	2	_	_	PUNCT
biomedich-1021	64	1	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	65	1	d	d	X
biomedich-1021	65	2	-8,1	-8,1	PROPN
biomedich-1021	65	3	1zfj_2'-o	1zfj_2'-o	NUM
biomedich-1021	65	4	methylisoliquiritigenin	methylisoliquiritigenin	NOUN
biomedich-1021	65	5	-8	-8	NOUN
biomedich-1021	65	6	1zfj	1zfj	NUM
biomedich-1021	65	7	_	_	SYM
biomedich-1021	65	8	loureirin	loureirin	NOUN
biomedich-1021	65	9	a	a	DET
biomedich-1021	65	10	-7,7	-7,7	ADJ
biomedich-1021	65	11	1zfj	1zfj	NUM
biomedich-1021	65	12	_	_	PRON
biomedich-1021	65	13	diphenolic	diphenolic	NOUN
biomedich-1021	65	14	acid	acid	NOUN
biomedich-1021	65	15	-7,7	-7,7	PROPN
biomedich-1021	65	16	1zfj_(2s)-5	1zfj_(2s)-5	NUM
biomedich-1021	65	17	-	-	PUNCT
biomedich-1021	65	18	methoxy-6	methoxy-6	NUM
biomedich-1021	65	19	-	-	PUNCT
biomedich-1021	65	20	methylflavan-7	methylflavan-7	NOUN
biomedich-1021	65	21	-	-	PUNCT
biomedich-1021	65	22	ol	ol	NOUN
biomedich-1021	65	23	-7,7	-7,7	ADJ
biomedich-1021	65	24	1zfj	1zfj	NUM
biomedich-1021	65	25	_	_	PUNCT
biomedich-1021	65	26	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	65	27	c	c	NOUN
biomedich-1021	65	28	-7,5	-7,5	PUNCT
biomedich-1021	66	1	1zfj	1zfj	NUM
biomedich-1021	66	2	_	_	NOUN
biomedich-1021	66	3	davidigenin	davidigenin	ADJ
biomedich-1021	66	4	-7,4	-7,4	PUNCT
biomedich-1021	67	1	1zfj	1zfj	NUM
biomedich-1021	67	2	_	_	PUNCT
biomedich-1021	67	3	trans-3,5	trans-3,5	NUM
biomedich-1021	67	4	-	-	PUNCT
biomedich-1021	67	5	dihydroxy-4'-methoxystilbene	dihydroxy-4'-methoxystilbene	NOUN
biomedich-1021	67	6	-7,4	-7,4	PUNCT
biomedich-1021	67	7	1zfj_4,4'-dihydroxy-2,6	1zfj_4,4'-dihydroxy-2,6	NUM
biomedich-1021	67	8	-	-	PUNCT
biomedich-1021	67	9	dimethoxydihydrochalcone	dimethoxydihydrochalcone	NOUN
biomedich-1021	67	10	-7,1	-7,1	PROPN
biomedich-1021	67	11	1zfj_4'-hydroxy-2,6	1zfj_4'-hydroxy-2,6	NUM
biomedich-1021	67	12	-	-	PUNCT
biomedich-1021	67	13	dimethoxydihydrochalcone	dimethoxydihydrochalcone	NOUN
biomedich-1021	67	14	-6,7	-6,7	NOUN
biomedich-1021	67	15	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	67	16	(	(	PUNCT
biomedich-1021	67	17	adme	adme	NOUN
biomedich-1021	67	18	)	)	PUNCT
biomedich-1021	67	19	profile	profile	NOUN
biomedich-1021	67	20	of	of	ADP
biomedich-1021	67	21	prioritized	prioritized	ADJ
biomedich-1021	67	22	candidates	candidate	NOUN
biomedich-1021	67	23	the	the	DET
biomedich-1021	67	24	adme	adme	NOUN
biomedich-1021	67	25	properties	property	NOUN
biomedich-1021	67	26	of	of	ADP
biomedich-1021	67	27	the	the	DET
biomedich-1021	67	28	11	11	NUM
biomedich-1021	67	29	prioritized	prioritize	VERB
biomedich-1021	67	30	compounds	compound	NOUN
biomedich-1021	67	31	were	be	AUX
biomedich-1021	67	32	predicted	predict	VERB
biomedich-1021	67	33	to	to	PART
biomedich-1021	67	34	assess	assess	VERB
biomedich-1021	67	35	their	their	PRON
biomedich-1021	67	36	potential	potential	ADJ
biomedich-1021	67	37	behavior	behavior	NOUN
biomedich-1021	67	38	in	in	ADP
biomedich-1021	67	39	vivo	vivo	NOUN
biomedich-1021	67	40	(	(	PUNCT
biomedich-1021	67	41	table	table	NOUN
biomedich-1021	67	42	3	3	NUM
biomedich-1021	67	43	)	)	PUNCT
biomedich-1021	67	44	.	.	PUNCT
biomedich-1021	68	1	all	all	DET
biomedich-1021	68	2	11	11	NUM
biomedich-1021	68	3	compounds	compound	NOUN
biomedich-1021	68	4	demonstrated	demonstrate	VERB
biomedich-1021	68	5	high	high	ADJ
biomedich-1021	68	6	predicted	predict	VERB
biomedich-1021	68	7	human	human	ADJ
biomedich-1021	68	8	intestinal	intestinal	ADJ
biomedich-1021	68	9	absorption	absorption	NOUN
biomedich-1021	68	10	(	(	PUNCT
biomedich-1021	68	11	hia	hia	X
biomedich-1021	68	12	>	>	X
biomedich-1021	68	13	85	85	NUM
biomedich-1021	68	14	%	%	NOUN
biomedich-1021	68	15	)	)	PUNCT
biomedich-1021	68	16	,	,	PUNCT
biomedich-1021	68	17	suggesting	suggest	VERB
biomedich-1021	68	18	excellent	excellent	ADJ
biomedich-1021	68	19	absorption	absorption	NOUN
biomedich-1021	68	20	from	from	ADP
biomedich-1021	68	21	the	the	DET
biomedich-1021	68	22	gastrointestinal	gastrointestinal	ADJ
biomedich-1021	68	23	tract	tract	NOUN
biomedich-1021	68	24	.	.	PUNCT
biomedich-1021	69	1	however	however	ADV
biomedich-1021	69	2	,	,	PUNCT
biomedich-1021	69	3	variability	variability	NOUN
biomedich-1021	69	4	was	be	AUX
biomedich-1021	69	5	noted	note	VERB
biomedich-1021	69	6	in	in	ADP
biomedich-1021	69	7	their	their	PRON
biomedich-1021	69	8	distribution	distribution	NOUN
biomedich-1021	69	9	properties	property	NOUN
biomedich-1021	69	10	.	.	PUNCT
biomedich-1021	70	1	for	for	ADP
biomedich-1021	70	2	instance	instance	NOUN
biomedich-1021	70	3	,	,	PUNCT
biomedich-1021	70	4	only	only	ADV
biomedich-1021	70	5	isopimaric	isopimaric	ADJ
biomedich-1021	70	6	acid	acid	NOUN
biomedich-1021	70	7	and	and	CCONJ
biomedich-1021	70	8	(	(	PUNCT
biomedich-1021	70	9	2s)-5methoxy-6	2s)-5methoxy-6	NUM
biomedich-1021	70	10	-	-	PUNCT
biomedich-1021	70	11	methylflavan-7	methylflavan-7	NOUN
biomedich-1021	70	12	-	-	PUNCT
biomedich-1021	70	13	ol	ol	PROPN
biomedich-1021	70	14	were	be	AUX
biomedich-1021	70	15	predicted	predict	VERB
biomedich-1021	70	16	to	to	PART
biomedich-1021	70	17	penetrate	penetrate	VERB
biomedich-1021	70	18	the	the	DET
biomedich-1021	70	19	blood	blood	NOUN
biomedich-1021	70	20	-	-	PUNCT
biomedich-1021	70	21	brain	brain	NOUN
biomedich-1021	70	22	barrier	barrier	NOUN
biomedich-1021	70	23	(	(	PUNCT
biomedich-1021	70	24	bbb	bbb	NOUN
biomedich-1021	70	25	)	)	PUNCT
biomedich-1021	70	26	.	.	PUNCT
biomedich-1021	71	1	in	in	ADP
biomedich-1021	71	2	terms	term	NOUN
biomedich-1021	71	3	of	of	ADP
biomedich-1021	71	4	metabolism	metabolism	NOUN
biomedich-1021	71	5	,	,	PUNCT
biomedich-1021	71	6	several	several	ADJ
biomedich-1021	71	7	compounds	compound	NOUN
biomedich-1021	71	8	,	,	PUNCT
biomedich-1021	71	9	including	include	VERB
biomedich-1021	71	10	loureirin	loureirin	NOUN
biomedich-1021	71	11	a	a	PRON
biomedich-1021	71	12	and	and	CCONJ
biomedich-1021	71	13	the	the	DET
biomedich-1021	71	14	two	two	NUM
biomedich-1021	71	15	dihydrochalcones	dihydrochalcone	NOUN
biomedich-1021	71	16	,	,	PUNCT
biomedich-1021	71	17	were	be	AUX
biomedich-1021	71	18	predicted	predict	VERB
biomedich-1021	71	19	to	to	PART
biomedich-1021	71	20	be	be	AUX
biomedich-1021	71	21	inhibitors	inhibitor	NOUN
biomedich-1021	71	22	of	of	ADP
biomedich-1021	71	23	key	key	ADJ
biomedich-1021	71	24	cytochrome	cytochrome	NOUN
biomedich-1021	71	25	p450	p450	NUM
biomedich-1021	71	26	enzymes	enzyme	NOUN
biomedich-1021	71	27	(	(	PUNCT
biomedich-1021	71	28	cyp3a4	cyp3a4	NOUN
biomedich-1021	71	29	or	or	CCONJ
biomedich-1021	71	30	cyp2d6	cyp2d6	NOUN
biomedich-1021	71	31	)	)	PUNCT
biomedich-1021	71	32	,	,	PUNCT
biomedich-1021	71	33	which	which	PRON
biomedich-1021	71	34	is	be	AUX
biomedich-1021	71	35	a	a	DET
biomedich-1021	71	36	critical	critical	ADJ
biomedich-1021	71	37	consideration	consideration	NOUN
biomedich-1021	71	38	for	for	ADP
biomedich-1021	71	39	potential	potential	ADJ
biomedich-1021	71	40	drug	drug	NOUN
biomedich-1021	71	41	-	-	PUNCT
biomedich-1021	71	42	drug	drug	NOUN
biomedich-1021	71	43	interactions	interaction	NOUN
biomedich-1021	71	44	(	(	PUNCT
biomedich-1021	71	45	pires	pire	NOUN
biomedich-1021	71	46	et	et	PROPN
biomedich-1021	71	47	al	al	PROPN
biomedich-1021	71	48	.	.	PROPN
biomedich-1021	71	49	,	,	PUNCT
biomedich-1021	71	50	2015	2015	NUM
biomedich-1021	71	51	)	)	PUNCT
biomedich-1021	71	52	.	.	PUNCT
biomedich-1021	72	1	1268	1268	NUM
biomedich-1021	72	2	biology	biology	NOUN
biomedich-1021	72	3	,	,	PUNCT
biomedich-1021	72	4	medicine	medicine	NOUN
biomedich-1021	72	5	,	,	PUNCT
biomedich-1021	72	6	&	&	CCONJ
biomedich-1021	72	7	natural	natural	ADJ
biomedich-1021	72	8	product	product	NOUN
biomedich-1021	72	9	chemistry	chemistry	NOUN
biomedich-1021	72	10	14	14	NUM
biomedich-1021	72	11	(	(	PUNCT
biomedich-1021	72	12	2	2	NUM
biomedich-1021	72	13	)	)	PUNCT
biomedich-1021	72	14	,	,	PUNCT
biomedich-1021	72	15	2025	2025	NUM
biomedich-1021	72	16	:	:	PUNCT
biomedich-1021	72	17	1265	1265	NUM
biomedich-1021	72	18	-	-	SYM
biomedich-1021	72	19	1271	1271	NUM
biomedich-1021	72	20	table	table	NOUN
biomedich-1021	72	21	3	3	NUM
biomedich-1021	72	22	.	.	PUNCT
biomedich-1021	72	23	predicted	predict	VERB
biomedich-1021	72	24	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	72	25	(	(	PUNCT
biomedich-1021	72	26	adme	adme	NOUN
biomedich-1021	72	27	)	)	PUNCT
biomedich-1021	72	28	profile	profile	NOUN
biomedich-1021	72	29	of	of	ADP
biomedich-1021	72	30	the	the	DET
biomedich-1021	72	31	filtered	filter	VERB
biomedich-1021	72	32	candidate	candidate	NOUN
biomedich-1021	72	33	compounds	compound	NOUN
biomedich-1021	72	34	.	.	PUNCT
biomedich-1021	73	1	compound	compound	NOUN
biomedich-1021	73	2	name	name	NOUN
biomedich-1021	73	3	hia	hia	PROPN
biomedich-1021	73	4	(	(	PUNCT
biomedich-1021	73	5	%	%	INTJ
biomedich-1021	73	6	)	)	PUNCT
biomedich-1021	73	7	skin	skin	NOUN
biomedich-1021	73	8	permeability	permeability	NOUN
biomedich-1021	73	9	(	(	PUNCT
biomedich-1021	73	10	log	log	PROPN
biomedich-1021	73	11	kp	kp	NOUN
biomedich-1021	73	12	)	)	PUNCT
biomedich-1021	73	13	bbb	bbb	PROPN
biomedich-1021	73	14	penetrant	penetrant	NOUN
biomedich-1021	73	15	vdss	vdss	ADV
biomedich-1021	73	16	(	(	PUNCT
biomedich-1021	73	17	log	log	NOUN
biomedich-1021	73	18	l	l	NOUN
biomedich-1021	73	19	/	/	SYM
biomedich-1021	73	20	kg	kg	NOUN
biomedich-1021	73	21	)	)	PUNCT
biomedich-1021	73	22	cyp2d6	cyp2d6	NOUN
biomedich-1021	73	23	inhibitor	inhibitor	NOUN
biomedich-1021	73	24	cyp3a4	cyp3a4	PROPN
biomedich-1021	73	25	inhibitor	inhibitor	NOUN
biomedich-1021	73	26	total	total	NOUN
biomedich-1021	73	27	clearance	clearance	NOUN
biomedich-1021	73	28	(	(	PUNCT
biomedich-1021	73	29	log	log	VERB
biomedich-1021	73	30	ml	ml	NOUN
biomedich-1021	73	31	/	/	SYM
biomedich-1021	73	32	min	min	NOUN
biomedich-1021	73	33	/	/	SYM
biomedich-1021	73	34	kg	kg	NOUN
biomedich-1021	73	35	)	)	PUNCT
biomedich-1021	73	36	isopimaric	isopimaric	ADJ
biomedich-1021	73	37	acid	acid	NOUN
biomedich-1021	73	38	95.8	95.8	NUM
biomedich-1021	73	39	-2.04	-2.04	NUM
biomedich-1021	74	1	yes	yes	INTJ
biomedich-1021	74	2	0.39	0.39	NUM
biomedich-1021	75	1	no	no	INTJ
biomedich-1021	75	2	no	no	DET
biomedich-1021	75	3	1.27	1.27	NUM
biomedich-1021	75	4	2'-o	2'-o	NUM
biomedich-1021	75	5	methylisoliquiritigenin	methylisoliquiritigenin	NOUN
biomedich-1021	75	6	92.1	92.1	NUM
biomedich-1021	75	7	-2.06	-2.06	NOUN
biomedich-1021	75	8	no	no	DET
biomedich-1021	75	9	0.98	0.98	NUM
biomedich-1021	75	10	no	no	INTJ
biomedich-1021	75	11	no	no	DET
biomedich-1021	75	12	4.28	4.28	NUM
biomedich-1021	75	13	loureirin	loureirin	NOUN
biomedich-1021	75	14	a	a	DET
biomedich-1021	75	15	93.3	93.3	NUM
biomedich-1021	75	16	-2.76	-2.76	NOUN
biomedich-1021	76	1	no	no	INTJ
biomedich-1021	76	2	0.76	0.76	NUM
biomedich-1021	76	3	no	no	INTJ
biomedich-1021	77	1	yes	yes	INTJ
biomedich-1021	77	2	5.65	5.65	NUM
biomedich-1021	77	3	davidigenin	davidigenin	NOUN
biomedich-1021	77	4	90.1	90.1	NUM
biomedich-1021	77	5	-1.98	-1.98	NUM
biomedich-1021	77	6	no	no	DET
biomedich-1021	77	7	0.81	0.81	NUM
biomedich-1021	77	8	no	no	INTJ
biomedich-1021	78	1	no	no	DET
biomedich-1021	78	2	5.43	5.43	NUM
biomedich-1021	78	3	4'-hydroxy-2,6dimethoxydihydrochalcone	4'-hydroxy-2,6dimethoxydihydrochalcone	NUM
biomedich-1021	78	4	92.5	92.5	NUM
biomedich-1021	78	5	-2.53	-2.53	NOUN
biomedich-1021	78	6	no	no	DET
biomedich-1021	78	7	1.09	1.09	NUM
biomedich-1021	78	8	no	no	INTJ
biomedich-1021	79	1	yes	yes	INTJ
biomedich-1021	79	2	6.59	6.59	NUM
biomedich-1021	79	3	4,4'-dihydroxy-2,6dimethoxydihydrochalcone	4,4'-dihydroxy-2,6dimethoxydihydrochalcone	PROPN
biomedich-1021	79	4	93.1	93.1	NUM
biomedich-1021	79	5	-2.58	-2.58	NOUN
biomedich-1021	79	6	no	no	DET
biomedich-1021	79	7	1.37	1.37	NUM
biomedich-1021	80	1	yes	yes	INTJ
biomedich-1021	81	1	yes	yes	INTJ
biomedich-1021	81	2	8.10	8.10	NUM
biomedich-1021	81	3	diphenolic	diphenolic	NOUN
biomedich-1021	81	4	acid	acid	NOUN
biomedich-1021	81	5	85.9	85.9	NUM
biomedich-1021	81	6	-1.53	-1.53	NOUN
biomedich-1021	81	7	no	no	DET
biomedich-1021	81	8	0.47	0.47	NUM
biomedich-1021	81	9	no	no	INTJ
biomedich-1021	82	1	no	no	DET
biomedich-1021	82	2	3.21	3.21	NUM
biomedich-1021	82	3	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	82	4	c	c	PROPN
biomedich-1021	82	5	88.3	88.3	NUM
biomedich-1021	82	6	-0.57	-0.57	NOUN
biomedich-1021	83	1	no	no	DET
biomedich-1021	83	2	0.66	0.66	NUM
biomedich-1021	83	3	yes	yes	INTJ
biomedich-1021	84	1	yes	yes	INTJ
biomedich-1021	84	2	7.40	7.40	NUM
biomedich-1021	84	3	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	85	1	d	d	X
biomedich-1021	85	2	87.5	87.5	NUM
biomedich-1021	85	3	0.52	0.52	NUM
biomedich-1021	85	4	no	no	DET
biomedich-1021	85	5	0.64	0.64	NUM
biomedich-1021	86	1	yes	yes	INTJ
biomedich-1021	87	1	yes	yes	INTJ
biomedich-1021	87	2	6.81	6.81	NUM
biomedich-1021	88	1	trans-3,5	trans-3,5	NOUN
biomedich-1021	88	2	-	-	PUNCT
biomedich-1021	88	3	dihydroxy-4'methoxystilbene	dihydroxy-4'methoxystilbene	VERB
biomedich-1021	88	4	91.2	91.2	NUM
biomedich-1021	88	5	-2.20	-2.20	NUM
biomedich-1021	88	6	no	no	DET
biomedich-1021	88	7	1.38	1.38	NUM
biomedich-1021	88	8	no	no	INTJ
biomedich-1021	89	1	yes	yes	INTJ
biomedich-1021	89	2	4.54	4.54	NUM
biomedich-1021	89	3	(	(	PUNCT
biomedich-1021	89	4	2s)-5	2s)-5	NUM
biomedich-1021	89	5	-	-	PUNCT
biomedich-1021	89	6	methoxy-6	methoxy-6	NUM
biomedich-1021	89	7	-	-	PUNCT
biomedich-1021	89	8	methylflavan7	methylflavan7	NOUN
biomedich-1021	89	9	-	-	PUNCT
biomedich-1021	89	10	ol	ol	INTJ
biomedich-1021	89	11	93.5	93.5	NUM
biomedich-1021	89	12	-2.32	-2.32	NOUN
biomedich-1021	90	1	yes	yes	INTJ
biomedich-1021	90	2	2.15	2.15	NUM
biomedich-1021	90	3	yes	yes	INTJ
biomedich-1021	90	4	no	no	DET
biomedich-1021	90	5	7.10	7.10	NUM
biomedich-1021	90	6	penicillin	penicillin	NOUN
biomedich-1021	90	7	g	g	PROPN
biomedich-1021	90	8	(	(	PUNCT
biomedich-1021	90	9	control	control	PROPN
biomedich-1021	90	10	)	)	PUNCT
biomedich-1021	90	11	89.9	89.9	NUM
biomedich-1021	90	12	-3.64	-3.64	NUM
biomedich-1021	90	13	no	no	DET
biomedich-1021	90	14	0.26	0.26	NUM
biomedich-1021	90	15	no	no	INTJ
biomedich-1021	90	16	no	no	DET
biomedich-1021	90	17	5.47	5.47	NUM
biomedich-1021	90	18	hia	hia	NOUN
biomedich-1021	90	19	:	:	PUNCT
biomedich-1021	90	20	human	human	ADJ
biomedich-1021	90	21	intestinal	intestinal	ADJ
biomedich-1021	90	22	absorption	absorption	NOUN
biomedich-1021	90	23	;	;	PUNCT
biomedich-1021	90	24	bbb	bbb	NUM
biomedich-1021	90	25	:	:	PUNCT
biomedich-1021	90	26	blood	blood	NOUN
biomedich-1021	90	27	-	-	PUNCT
biomedich-1021	90	28	brain	brain	NOUN
biomedich-1021	90	29	barrier	barrier	NOUN
biomedich-1021	90	30	;	;	PUNCT
biomedich-1021	90	31	vdss	vdss	ADV
biomedich-1021	90	32	:	:	PUNCT
biomedich-1021	90	33	volume	volume	NOUN
biomedich-1021	90	34	of	of	ADP
biomedich-1021	90	35	distribution	distribution	NOUN
biomedich-1021	90	36	at	at	ADP
biomedich-1021	90	37	steady	steady	ADJ
biomedich-1021	90	38	state	state	NOUN
biomedich-1021	90	39	.	.	PUNCT
biomedich-1021	91	1	toxicity	toxicity	NOUN
biomedich-1021	91	2	profile	profile	NOUN
biomedich-1021	91	3	of	of	ADP
biomedich-1021	91	4	prioritized	prioritized	ADJ
biomedich-1021	91	5	candidates	candidate	NOUN
biomedich-1021	91	6	the	the	DET
biomedich-1021	91	7	safety	safety	NOUN
biomedich-1021	91	8	profiles	profile	NOUN
biomedich-1021	91	9	of	of	ADP
biomedich-1021	91	10	the	the	DET
biomedich-1021	91	11	11	11	NUM
biomedich-1021	91	12	candidate	candidate	NOUN
biomedich-1021	91	13	compounds	compound	NOUN
biomedich-1021	91	14	were	be	AUX
biomedich-1021	91	15	assessed	assess	VERB
biomedich-1021	91	16	using	use	VERB
biomedich-1021	91	17	several	several	ADJ
biomedich-1021	91	18	key	key	ADJ
biomedich-1021	91	19	toxicity	toxicity	NOUN
biomedich-1021	91	20	endpoints	endpoint	NOUN
biomedich-1021	91	21	(	(	PUNCT
biomedich-1021	91	22	table	table	NOUN
biomedich-1021	91	23	4	4	NUM
biomedich-1021	91	24	)	)	PUNCT
biomedich-1021	91	25	.	.	PUNCT
biomedich-1021	92	1	a	a	DET
biomedich-1021	92	2	crucial	crucial	ADJ
biomedich-1021	92	3	finding	finding	NOUN
biomedich-1021	92	4	was	be	AUX
biomedich-1021	92	5	that	that	SCONJ
biomedich-1021	92	6	all	all	DET
biomedich-1021	92	7	compounds	compound	NOUN
biomedich-1021	92	8	were	be	AUX
biomedich-1021	92	9	predicted	predict	VERB
biomedich-1021	92	10	to	to	PART
biomedich-1021	92	11	be	be	AUX
biomedich-1021	92	12	non	non	ADJ
biomedich-1021	92	13	-	-	ADJ
biomedich-1021	92	14	mutagenic	mutagenic	ADJ
biomedich-1021	92	15	in	in	ADP
biomedich-1021	92	16	the	the	DET
biomedich-1021	92	17	ames	ames	PROPN
biomedich-1021	92	18	test	test	NOUN
biomedich-1021	92	19	,	,	PUNCT
biomedich-1021	92	20	a	a	DET
biomedich-1021	92	21	highly	highly	ADV
biomedich-1021	92	22	desirable	desirable	ADJ
biomedich-1021	92	23	attribute	attribute	NOUN
biomedich-1021	92	24	for	for	ADP
biomedich-1021	92	25	any	any	DET
biomedich-1021	92	26	drug	drug	NOUN
biomedich-1021	92	27	candidate	candidate	NOUN
biomedich-1021	92	28	.	.	PUNCT
biomedich-1021	93	1	in	in	ADP
biomedich-1021	93	2	terms	term	NOUN
biomedich-1021	93	3	of	of	ADP
biomedich-1021	93	4	acute	acute	ADJ
biomedich-1021	93	5	oral	oral	ADJ
biomedich-1021	93	6	toxicity	toxicity	NOUN
biomedich-1021	93	7	,	,	PUNCT
biomedich-1021	93	8	the	the	DET
biomedich-1021	93	9	compounds	compound	NOUN
biomedich-1021	93	10	ranged	range	VERB
biomedich-1021	93	11	from	from	ADP
biomedich-1021	93	12	class	class	NOUN
biomedich-1021	93	13	4	4	NUM
biomedich-1021	93	14	to	to	ADP
biomedich-1021	93	15	class	class	NOUN
biomedich-1021	93	16	5	5	NUM
biomedich-1021	93	17	,	,	PUNCT
biomedich-1021	93	18	with	with	ADP
biomedich-1021	93	19	isopimaric	isopimaric	ADJ
biomedich-1021	93	20	acid	acid	NOUN
biomedich-1021	93	21	(	(	PUNCT
biomedich-1021	93	22	ld50	ld50	PROPN
biomedich-1021	93	23	5000	5000	NUM
biomedich-1021	93	24	mg	mg	PROPN
biomedich-1021	93	25	/	/	SYM
biomedich-1021	93	26	kg	kg	PROPN
biomedich-1021	93	27	,	,	PUNCT
biomedich-1021	93	28	class	class	NOUN
biomedich-1021	93	29	5	5	NUM
biomedich-1021	93	30	)	)	PUNCT
biomedich-1021	93	31	being	be	AUX
biomedich-1021	93	32	predicted	predict	VERB
biomedich-1021	93	33	as	as	ADP
biomedich-1021	93	34	the	the	DET
biomedich-1021	93	35	least	least	ADJ
biomedich-1021	93	36	acutely	acutely	ADV
biomedich-1021	93	37	toxic	toxic	ADJ
biomedich-1021	93	38	.	.	PUNCT
biomedich-1021	94	1	the	the	DET
biomedich-1021	94	2	prediction	prediction	NOUN
biomedich-1021	94	3	for	for	ADP
biomedich-1021	94	4	drug	drug	NOUN
biomedich-1021	94	5	-	-	PUNCT
biomedich-1021	94	6	induced	induce	VERB
biomedich-1021	94	7	liver	liver	NOUN
biomedich-1021	94	8	injury	injury	NOUN
biomedich-1021	94	9	(	(	PUNCT
biomedich-1021	94	10	dili	dili	PROPN
biomedich-1021	94	11	)	)	PUNCT
biomedich-1021	94	12	identified	identify	VERB
biomedich-1021	94	13	several	several	ADJ
biomedich-1021	94	14	compounds	compound	NOUN
biomedich-1021	94	15	,	,	PUNCT
biomedich-1021	94	16	including	include	VERB
biomedich-1021	94	17	davidigenin	davidigenin	NOUN
biomedich-1021	94	18	and	and	CCONJ
biomedich-1021	94	19	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	94	20	d	d	NOUN
biomedich-1021	94	21	,	,	PUNCT
biomedich-1021	94	22	as	as	ADP
biomedich-1021	94	23	potentially	potentially	ADV
biomedich-1021	94	24	"	"	PUNCT
biomedich-1021	94	25	toxic	toxic	ADJ
biomedich-1021	94	26	.	.	PUNCT
biomedich-1021	94	27	"	"	PUNCT
biomedich-1021	95	1	conversely	conversely	ADV
biomedich-1021	95	2	,	,	PUNCT
biomedich-1021	95	3	isopimaric	isopimaric	ADJ
biomedich-1021	95	4	acid	acid	NOUN
biomedich-1021	95	5	and	and	CCONJ
biomedich-1021	95	6	loureirin	loureirin	NOUN
biomedich-1021	95	7	a	a	PRON
biomedich-1021	95	8	were	be	AUX
biomedich-1021	95	9	predicted	predict	VERB
biomedich-1021	95	10	to	to	PART
biomedich-1021	95	11	be	be	AUX
biomedich-1021	95	12	"	"	PUNCT
biomedich-1021	95	13	safe	safe	ADJ
biomedich-1021	95	14	.	.	PUNCT
biomedich-1021	95	15	"	"	PUNCT
biomedich-1021	96	1	significantly	significantly	ADV
biomedich-1021	96	2	,	,	PUNCT
biomedich-1021	96	3	the	the	DET
biomedich-1021	96	4	computational	computational	ADJ
biomedich-1021	96	5	model	model	NOUN
biomedich-1021	96	6	also	also	ADV
biomedich-1021	96	7	accurately	accurately	ADV
biomedich-1021	96	8	classified	classify	VERB
biomedich-1021	96	9	the	the	DET
biomedich-1021	96	10	control	control	NOUN
biomedich-1021	96	11	drug	drug	NOUN
biomedich-1021	96	12	,	,	PUNCT
biomedich-1021	96	13	penicillin	penicillin	NOUN
biomedich-1021	96	14	g	g	NOUN
biomedich-1021	96	15	,	,	PUNCT
biomedich-1021	96	16	as	as	ADP
biomedich-1021	96	17	"	"	PUNCT
biomedich-1021	96	18	safe	safe	ADJ
biomedich-1021	96	19	"	"	PUNCT
biomedich-1021	96	20	for	for	ADP
biomedich-1021	96	21	dili	dili	PROPN
biomedich-1021	96	22	,	,	PUNCT
biomedich-1021	96	23	which	which	PRON
biomedich-1021	96	24	is	be	AUX
biomedich-1021	96	25	consistent	consistent	ADJ
biomedich-1021	96	26	with	with	ADP
biomedich-1021	96	27	its	its	PRON
biomedich-1021	96	28	well	well	ADV
biomedich-1021	96	29	-	-	PUNCT
biomedich-1021	96	30	established	establish	VERB
biomedich-1021	96	31	clinical	clinical	ADJ
biomedich-1021	96	32	safety	safety	NOUN
biomedich-1021	96	33	profile	profile	NOUN
biomedich-1021	96	34	and	and	CCONJ
biomedich-1021	96	35	supports	support	VERB
biomedich-1021	96	36	the	the	DET
biomedich-1021	96	37	reliability	reliability	NOUN
biomedich-1021	96	38	of	of	ADP
biomedich-1021	96	39	the	the	DET
biomedich-1021	96	40	predictions	prediction	NOUN
biomedich-1021	96	41	for	for	ADP
biomedich-1021	96	42	the	the	DET
biomedich-1021	96	43	test	test	NOUN
biomedich-1021	96	44	compounds	compound	NOUN
biomedich-1021	96	45	.	.	PUNCT
biomedich-1021	97	1	table	table	NOUN
biomedich-1021	97	2	4	4	NUM
biomedich-1021	97	3	.	.	PUNCT
biomedich-1021	97	4	predicted	predict	VERB
biomedich-1021	97	5	toxicity	toxicity	NOUN
biomedich-1021	97	6	profiles	profile	NOUN
biomedich-1021	97	7	of	of	ADP
biomedich-1021	97	8	the	the	DET
biomedich-1021	97	9	filtered	filter	VERB
biomedich-1021	97	10	candidate	candidate	NOUN
biomedich-1021	97	11	compounds	compound	NOUN
biomedich-1021	97	12	.	.	PUNCT
biomedich-1021	98	1	no	no	INTJ
biomedich-1021	98	2	.	.	PUNCT
biomedich-1021	99	1	compound	compound	NOUN
biomedich-1021	99	2	name	name	NOUN
biomedich-1021	100	1	ld50	ld50	PROPN
biomedich-1021	100	2	(	(	PUNCT
biomedich-1021	100	3	mg	mg	PROPN
biomedich-1021	100	4	/	/	SYM
biomedich-1021	100	5	kg	kg	NOUN
biomedich-1021	100	6	)	)	PUNCT
biomedich-1021	100	7	toxicity	toxicity	NOUN
biomedich-1021	100	8	class	class	NOUN
biomedich-1021	100	9	*	*	PUNCT
biomedich-1021	100	10	ames	ames	PROPN
biomedich-1021	100	11	toxicity	toxicity	NOUN
biomedich-1021	100	12	dili	dili	PROPN
biomedich-1021	100	13	*	*	PROPN
biomedich-1021	100	14	*	*	PROPN
biomedich-1021	100	15	1	1	NUM
biomedich-1021	100	16	isopimaric	isopimaric	ADJ
biomedich-1021	100	17	acid	acid	NOUN
biomedich-1021	100	18	5000	5000	NUM
biomedich-1021	100	19	4	4	NUM
biomedich-1021	100	20	safe	safe	ADJ
biomedich-1021	100	21	safe	safe	ADJ
biomedich-1021	100	22	2	2	NUM
biomedich-1021	100	23	2'-o	2'-o	NUM
biomedich-1021	100	24	methylisoliquiritigenin	methylisoliquiritigenin	NOUN
biomedich-1021	100	25	1190	1190	NUM
biomedich-1021	100	26	4	4	NUM
biomedich-1021	100	27	safe	safe	ADJ
biomedich-1021	100	28	toxic	toxic	ADJ
biomedich-1021	100	29	3	3	NUM
biomedich-1021	100	30	loureirin	loureirin	NOUN
biomedich-1021	100	31	a	a	DET
biomedich-1021	100	32	500	500	NUM
biomedich-1021	100	33	4	4	NUM
biomedich-1021	100	34	safe	safe	ADJ
biomedich-1021	100	35	safe	safe	ADJ
biomedich-1021	100	36	4	4	NUM
biomedich-1021	100	37	davidigenin	davidigenin	ADJ
biomedich-1021	100	38	500	500	NUM
biomedich-1021	100	39	4	4	NUM
biomedich-1021	100	40	safe	safe	ADJ
biomedich-1021	100	41	toxic	toxic	ADJ
biomedich-1021	100	42	5	5	NUM
biomedich-1021	100	43	4'-hydroxy-2,6	4'-hydroxy-2,6	NUM
biomedich-1021	100	44	-	-	PUNCT
biomedich-1021	100	45	dimethoxydihydrochalcone	dimethoxydihydrochalcone	NOUN
biomedich-1021	100	46	1190	1190	NUM
biomedich-1021	100	47	4	4	NUM
biomedich-1021	100	48	safe	safe	ADJ
biomedich-1021	100	49	safe	safe	ADJ
biomedich-1021	100	50	6	6	NUM
biomedich-1021	100	51	4,4'-dihydroxy-2,6	4,4'-dihydroxy-2,6	NOUN
biomedich-1021	100	52	-	-	PUNCT
biomedich-1021	100	53	dimethoxydihydrochalcone	dimethoxydihydrochalcone	NOUN
biomedich-1021	100	54	1190	1190	NUM
biomedich-1021	100	55	4	4	NUM
biomedich-1021	100	56	safe	safe	ADJ
biomedich-1021	100	57	safe	safe	ADJ
biomedich-1021	100	58	7	7	NUM
biomedich-1021	100	59	diphenolic	diphenolic	NOUN
biomedich-1021	100	60	acid	acid	NOUN
biomedich-1021	100	61	1320	1320	NUM
biomedich-1021	100	62	4	4	NUM
biomedich-1021	100	63	safe	safe	ADJ
biomedich-1021	100	64	toxic	toxic	ADJ
biomedich-1021	100	65	8	8	NUM
biomedich-1021	100	66	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	100	67	c	c	NOUN
biomedich-1021	100	68	302	302	NUM
biomedich-1021	100	69	4	4	NUM
biomedich-1021	100	70	safe	safe	ADJ
biomedich-1021	100	71	toxic	toxic	ADJ
biomedich-1021	100	72	9	9	NUM
biomedich-1021	100	73	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	100	74	d	d	X
biomedich-1021	100	75	302	302	NUM
biomedich-1021	100	76	4	4	NUM
biomedich-1021	100	77	safe	safe	ADJ
biomedich-1021	100	78	toxic	toxic	ADJ
biomedich-1021	100	79	10	10	NUM
biomedich-1021	100	80	trans-3,5	trans-3,5	NUM
biomedich-1021	100	81	-	-	PUNCT
biomedich-1021	100	82	dihydroxy-4'-methoxystilbene	dihydroxy-4'-methoxystilbene	NOUN
biomedich-1021	100	83	2090	2090	NUM
biomedich-1021	100	84	5	5	NUM
biomedich-1021	100	85	safe	safe	ADJ
biomedich-1021	100	86	toxic	toxic	ADJ
biomedich-1021	100	87	11	11	NUM
biomedich-1021	100	88	(	(	PUNCT
biomedich-1021	100	89	2s)-5	2s)-5	NUM
biomedich-1021	100	90	-	-	PUNCT
biomedich-1021	100	91	methoxy-6	methoxy-6	NUM
biomedich-1021	100	92	-	-	PUNCT
biomedich-1021	100	93	methylflavan-7	methylflavan-7	NOUN
biomedich-1021	100	94	-	-	PUNCT
biomedich-1021	100	95	ol	ol	ADJ
biomedich-1021	100	96	2500	2500	NUM
biomedich-1021	100	97	5	5	NUM
biomedich-1021	100	98	safe	safe	ADJ
biomedich-1021	100	99	safe	safe	ADJ
biomedich-1021	100	100	12	12	NUM
biomedich-1021	100	101	penicillin	penicillin	NOUN
biomedich-1021	100	102	g	g	PROPN
biomedich-1021	100	103	(	(	PUNCT
biomedich-1021	100	104	control	control	PROPN
biomedich-1021	100	105	)	)	PUNCT
biomedich-1021	100	106	1000	1000	NUM
biomedich-1021	100	107	4	4	NUM
biomedich-1021	100	108	safe	safe	ADJ
biomedich-1021	100	109	safe	safe	ADJ
biomedich-1021	100	110	*	*	NOUN
biomedich-1021	100	111	toxicity	toxicity	NOUN
biomedich-1021	100	112	class	class	NOUN
biomedich-1021	100	113	based	base	VERB
biomedich-1021	100	114	on	on	ADP
biomedich-1021	100	115	globally	globally	ADV
biomedich-1021	100	116	harmonized	harmonized	ADJ
biomedich-1021	100	117	system	system	NOUN
biomedich-1021	100	118	(	(	PUNCT
biomedich-1021	100	119	ghs	ghs	NOUN
biomedich-1021	100	120	):	):	PUNCT
biomedich-1021	100	121	class	class	NOUN
biomedich-1021	100	122	4	4	NUM
biomedich-1021	100	123	(	(	PUNCT
biomedich-1021	100	124	300	300	NUM
biomedich-1021	100	125	<	<	X
biomedich-1021	100	126	ld50	ld50	PROPN
biomedich-1021	100	127	≤	≤	PROPN
biomedich-1021	100	128	2000	2000	NUM
biomedich-1021	100	129	,	,	PUNCT
biomedich-1021	100	130	warning	warning	NOUN
biomedich-1021	100	131	)	)	PUNCT
biomedich-1021	100	132	&	&	CCONJ
biomedich-1021	100	133	class	class	PROPN
biomedich-1021	100	134	5	5	NUM
biomedich-1021	100	135	(	(	PUNCT
biomedich-1021	100	136	2000	2000	NUM
biomedich-1021	100	137	<	<	X
biomedich-1021	100	138	ld50	ld50	PROPN
biomedich-1021	100	139	≤	≤	NOUN
biomedich-1021	100	140	5000	5000	NUM
biomedich-1021	100	141	,	,	PUNCT
biomedich-1021	100	142	warning	warning	NOUN
biomedich-1021	100	143	may	may	AUX
biomedich-1021	100	144	be	be	AUX
biomedich-1021	100	145	harmful	harmful	ADJ
biomedich-1021	100	146	)	)	PUNCT
biomedich-1021	100	147	.	.	PUNCT
biomedich-1021	101	1	*	*	PUNCT
biomedich-1021	101	2	*	*	PUNCT
biomedich-1021	101	3	dili	dili	NOUN
biomedich-1021	101	4	:	:	PUNCT
biomedich-1021	101	5	drug	drug	NOUN
biomedich-1021	101	6	-	-	PUNCT
biomedich-1021	101	7	induced	induce	VERB
biomedich-1021	101	8	liver	liver	NOUN
biomedich-1021	101	9	injury	injury	NOUN
biomedich-1021	101	10	.	.	PUNCT
biomedich-1021	102	1	analysis	analysis	NOUN
biomedich-1021	102	2	of	of	ADP
biomedich-1021	102	3	ligand	ligand	NOUN
biomedich-1021	102	4	-	-	PUNCT
biomedich-1021	102	5	receptor	receptor	NOUN
biomedich-1021	102	6	interactions	interaction	NOUN
biomedich-1021	102	7	to	to	PART
biomedich-1021	102	8	understand	understand	VERB
biomedich-1021	102	9	the	the	DET
biomedich-1021	102	10	molecular	molecular	ADJ
biomedich-1021	102	11	basis	basis	NOUN
biomedich-1021	102	12	for	for	ADP
biomedich-1021	102	13	the	the	DET
biomedich-1021	102	14	high	high	ADJ
biomedich-1021	102	15	binding	bind	VERB
biomedich-1021	102	16	affinities	affinity	NOUN
biomedich-1021	102	17	observed	observe	VERB
biomedich-1021	102	18	in	in	ADP
biomedich-1021	102	19	docking	docking	NOUN
biomedich-1021	102	20	,	,	PUNCT
biomedich-1021	102	21	the	the	DET
biomedich-1021	102	22	specific	specific	ADJ
biomedich-1021	102	23	interactions	interaction	NOUN
biomedich-1021	102	24	between	between	ADP
biomedich-1021	102	25	the	the	DET
biomedich-1021	102	26	ligands	ligand	NOUN
biomedich-1021	102	27	and	and	CCONJ
biomedich-1021	102	28	the	the	DET
biomedich-1021	102	29	impdh	impdh	NOUN
biomedich-1021	102	30	active	active	ADJ
biomedich-1021	102	31	site	site	NOUN
biomedich-1021	102	32	were	be	AUX
biomedich-1021	102	33	analyzed	analyze	VERB
biomedich-1021	102	34	.	.	PUNCT
biomedich-1021	103	1	table	table	NOUN
biomedich-1021	103	2	5	5	NUM
biomedich-1021	103	3	provides	provide	VERB
biomedich-1021	103	4	a	a	DET
biomedich-1021	103	5	summary	summary	NOUN
biomedich-1021	103	6	of	of	ADP
biomedich-1021	103	7	the	the	DET
biomedich-1021	103	8	key	key	ADJ
biomedich-1021	103	9	interacting	interacting	ADJ
biomedich-1021	103	10	residues	residue	NOUN
biomedich-1021	103	11	for	for	ADP
biomedich-1021	103	12	each	each	PRON
biomedich-1021	103	13	of	of	ADP
biomedich-1021	103	14	the	the	DET
biomedich-1021	103	15	11	11	NUM
biomedich-1021	103	16	compounds	compound	NOUN
biomedich-1021	103	17	,	,	PUNCT
biomedich-1021	103	18	while	while	SCONJ
biomedich-1021	103	19	figure	figure	NOUN
biomedich-1021	103	20	1	1	NUM
biomedich-1021	103	21	illustrates	illustrate	VERB
biomedich-1021	103	22	the	the	DET
biomedich-1021	103	23	binding	bind	VERB
biomedich-1021	103	24	modes	mode	NOUN
biomedich-1021	103	25	of	of	ADP
biomedich-1021	103	26	the	the	DET
biomedich-1021	103	27	top	top	ADJ
biomedich-1021	103	28	three	three	NUM
biomedich-1021	103	29	candidates	candidate	NOUN
biomedich-1021	103	30	.	.	PUNCT
biomedich-1021	104	1	the	the	DET
biomedich-1021	104	2	potent	potent	ADJ
biomedich-1021	104	3	binding	binding	NOUN
biomedich-1021	104	4	of	of	ADP
biomedich-1021	104	5	isopimaric	isopimaric	ADJ
biomedich-1021	104	6	acid	acid	NOUN
biomedich-1021	104	7	(	(	PUNCT
biomedich-1021	104	8	-8.2	-8.2	PROPN
biomedich-1021	104	9	kcal	kcal	PROPN
biomedich-1021	104	10	/	/	SYM
biomedich-1021	104	11	mol	mol	NOUN
biomedich-1021	104	12	)	)	PUNCT
biomedich-1021	104	13	is	be	AUX
biomedich-1021	104	14	anchored	anchor	VERB
biomedich-1021	104	15	by	by	ADP
biomedich-1021	104	16	three	three	NUM
biomedich-1021	104	17	conventional	conventional	ADJ
biomedich-1021	104	18	hydrogen	hydrogen	NOUN
biomedich-1021	104	19	bonds	bond	NOUN
biomedich-1021	104	20	with	with	ADP
biomedich-1021	104	21	the	the	DET
biomedich-1021	104	22	side	side	NOUN
biomedich-1021	104	23	chains	chain	NOUN
biomedich-1021	104	24	of	of	ADP
biomedich-1021	104	25	thr312	thr312	PROPN
biomedich-1021	104	26	and	and	CCONJ
biomedich-1021	104	27	cys310	cys310	PROPN
biomedich-1021	104	28	.	.	PUNCT
biomedich-1021	105	1	similarly	similarly	ADV
biomedich-1021	105	2	,	,	PUNCT
biomedich-1021	105	3	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	105	4	d	d	PROPN
biomedich-1021	105	5	(	(	PUNCT
biomedich-1021	105	6	-8.1	-8.1	PROPN
biomedich-1021	105	7	kcal	kcal	PROPN
biomedich-1021	105	8	/	/	SYM
biomedich-1021	105	9	mol	mol	PROPN
biomedich-1021	105	10	)	)	PUNCT
biomedich-1021	105	11	achieves	achieve	VERB
biomedich-1021	105	12	its	its	PRON
biomedich-1021	105	13	stable	stable	ADJ
biomedich-1021	105	14	pose	pose	VERB
biomedich-1021	105	15	through	through	ADP
biomedich-1021	105	16	an	an	DET
biomedich-1021	105	17	extensive	extensive	ADJ
biomedich-1021	105	18	network	network	NOUN
biomedich-1021	105	19	of	of	ADP
biomedich-1021	105	20	hydrogen	hydrogen	NOUN
biomedich-1021	105	21	bonds	bond	NOUN
biomedich-1021	105	22	handayani	handayani	PROPN
biomedich-1021	105	23	et	et	PROPN
biomedich-1021	105	24	al	al	PROPN
biomedich-1021	105	25	.	.	PROPN
biomedich-1021	105	26	–	–	PUNCT
biomedich-1021	105	27	in	in	ADP
biomedich-1021	105	28	silico	silico	NOUN
biomedich-1021	105	29	inhibition	inhibition	NOUN
biomedich-1021	105	30	of	of	ADP
biomedich-1021	105	31	s.	s.	PROPN
biomedich-1021	105	32	pyogenes	pyogenes	PROPN
biomedich-1021	105	33	impdh	impdh	NOUN
biomedich-1021	105	34	1269	1269	NUM
biomedich-1021	105	35	with	with	ADP
biomedich-1021	105	36	residues	residue	NOUN
biomedich-1021	105	37	such	such	ADJ
biomedich-1021	105	38	as	as	ADP
biomedich-1021	105	39	lys208	lys208	PROPN
biomedich-1021	105	40	and	and	CCONJ
biomedich-1021	105	41	tyr120	tyr120	NOUN
biomedich-1021	105	42	,	,	PUNCT
biomedich-1021	105	43	complemented	complement	VERB
biomedich-1021	105	44	by	by	ADP
biomedich-1021	105	45	multiple	multiple	ADJ
biomedich-1021	105	46	hydrophobic	hydrophobic	NOUN
biomedich-1021	105	47	contacts	contact	NOUN
biomedich-1021	105	48	.	.	PUNCT
biomedich-1021	106	1	the	the	DET
biomedich-1021	106	2	consistent	consistent	ADJ
biomedich-1021	106	3	interaction	interaction	NOUN
biomedich-1021	106	4	of	of	ADP
biomedich-1021	106	5	multiple	multiple	ADJ
biomedich-1021	106	6	high	high	ADJ
biomedich-1021	106	7	-	-	PUNCT
biomedich-1021	106	8	affinity	affinity	NOUN
biomedich-1021	106	9	ligands	ligand	NOUN
biomedich-1021	106	10	with	with	ADP
biomedich-1021	106	11	residues	residue	NOUN
biomedich-1021	106	12	like	like	ADP
biomedich-1021	106	13	tyr120	tyr120	NOUN
biomedich-1021	106	14	and	and	CCONJ
biomedich-1021	106	15	gly124	gly124	PROPN
biomedich-1021	106	16	suggests	suggest	VERB
biomedich-1021	106	17	these	these	DET
biomedich-1021	106	18	residues	residue	NOUN
biomedich-1021	106	19	are	be	AUX
biomedich-1021	106	20	critical	critical	ADJ
biomedich-1021	106	21	for	for	ADP
biomedich-1021	106	22	ligand	ligand	ADJ
biomedich-1021	106	23	recognition	recognition	NOUN
biomedich-1021	106	24	and	and	CCONJ
biomedich-1021	106	25	stabilization	stabilization	NOUN
biomedich-1021	106	26	within	within	ADP
biomedich-1021	106	27	the	the	DET
biomedich-1021	106	28	catalytic	catalytic	ADJ
biomedich-1021	106	29	pocket	pocket	NOUN
biomedich-1021	106	30	.	.	PUNCT
biomedich-1021	107	1	table	table	NOUN
biomedich-1021	107	2	5	5	NUM
biomedich-1021	107	3	.	.	PUNCT
biomedich-1021	108	1	summary	summary	NOUN
biomedich-1021	108	2	of	of	ADP
biomedich-1021	108	3	key	key	ADJ
biomedich-1021	108	4	molecular	molecular	ADJ
biomedich-1021	108	5	interactions	interaction	NOUN
biomedich-1021	108	6	of	of	ADP
biomedich-1021	108	7	filtered	filter	VERB
biomedich-1021	108	8	ligands	ligand	NOUN
biomedich-1021	108	9	with	with	ADP
biomedich-1021	108	10	the	the	DET
biomedich-1021	108	11	impdh	impdh	NOUN
biomedich-1021	108	12	(	(	PUNCT
biomedich-1021	108	13	1zfj	1zfj	NUM
biomedich-1021	108	14	)	)	PUNCT
biomedich-1021	108	15	active	active	ADJ
biomedich-1021	108	16	site	site	NOUN
biomedich-1021	108	17	.	.	PUNCT
biomedich-1021	109	1	compound	compound	NOUN
biomedich-1021	109	2	name	name	NOUN
biomedich-1021	109	3	binding	bind	VERB
biomedich-1021	109	4	affinity	affinity	NOUN
biomedich-1021	109	5	(	(	PUNCT
biomedich-1021	109	6	kcal	kcal	NOUN
biomedich-1021	109	7	/	/	SYM
biomedich-1021	109	8	mol	mol	PROPN
biomedich-1021	109	9	)	)	PUNCT
biomedich-1021	109	10	key	key	ADJ
biomedich-1021	109	11	interacting	interact	VERB
biomedich-1021	109	12	residues	residue	NOUN
biomedich-1021	109	13	isopimaric	isopimaric	ADJ
biomedich-1021	109	14	acid	acid	PROPN
biomedich-1021	109	15	-8.2	-8.2	PROPN
biomedich-1021	109	16	thr312	thr312	PROPN
biomedich-1021	109	17	,	,	PUNCT
biomedich-1021	109	18	cys310	cys310	PROPN
biomedich-1021	109	19	,	,	PUNCT
biomedich-1021	109	20	ile309	ile309	PROPN
biomedich-1021	109	21	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	110	1	d	d	PROPN
biomedich-1021	110	2	-8.1	-8.1	PROPN
biomedich-1021	110	3	lys208	lys208	PROPN
biomedich-1021	110	4	,	,	PUNCT
biomedich-1021	110	5	tyr120	tyr120	NOUN
biomedich-1021	110	6	,	,	PUNCT
biomedich-1021	110	7	arg67	arg67	NOUN
biomedich-1021	110	8	,	,	PUNCT
biomedich-1021	110	9	ser93	ser93	PROPN
biomedich-1021	110	10	,	,	PUNCT
biomedich-1021	110	11	lys60	lys60	PROPN
biomedich-1021	110	12	,	,	PUNCT
biomedich-1021	110	13	ile63	ile63	PROPN
biomedich-1021	110	14	,	,	PUNCT
biomedich-1021	110	15	val97	val97	VERB
biomedich-1021	110	16	2'-o	2'-o	NUM
biomedich-1021	110	17	methylisoliquiritigenin	methylisoliquiritigenin	ADV
biomedich-1021	110	18	-8.0	-8.0	ADP
biomedich-1021	110	19	val97	val97	PROPN
biomedich-1021	110	20	,	,	PUNCT
biomedich-1021	110	21	gly124	gly124	PROPN
biomedich-1021	110	22	,	,	PUNCT
biomedich-1021	110	23	gly96	gly96	PROPN
biomedich-1021	110	24	,	,	PUNCT
biomedich-1021	110	25	ile122	ile122	PROPN
biomedich-1021	110	26	,	,	PUNCT
biomedich-1021	110	27	arg92	arg92	PROPN
biomedich-1021	110	28	,	,	PUNCT
biomedich-1021	110	29	leu200	leu200	PROPN
biomedich-1021	110	30	loureirin	loureirin	NOUN
biomedich-1021	110	31	a	a	DET
biomedich-1021	110	32	-7.7	-7.7	ADJ
biomedich-1021	110	33	gly124	gly124	PROPN
biomedich-1021	110	34	,	,	PUNCT
biomedich-1021	110	35	val97	val97	PROPN
biomedich-1021	110	36	,	,	PUNCT
biomedich-1021	110	37	gly96	gly96	PROPN
biomedich-1021	110	38	,	,	PUNCT
biomedich-1021	110	39	lys89	lys89	PROPN
biomedich-1021	110	40	,	,	PUNCT
biomedich-1021	110	41	arg92	arg92	PROPN
biomedich-1021	110	42	,	,	PUNCT
biomedich-1021	110	43	ile122	ile122	PROPN
biomedich-1021	110	44	diphenolic	diphenolic	NOUN
biomedich-1021	110	45	acid	acid	NOUN
biomedich-1021	110	46	-7.7	-7.7	PUNCT
biomedich-1021	110	47	tyr13	tyr13	PROPN
biomedich-1021	110	48	,	,	PUNCT
biomedich-1021	110	49	glu467	glu467	PROPN
biomedich-1021	110	50	,	,	PUNCT
biomedich-1021	110	51	ala463	ala463	PROPN
biomedich-1021	110	52	,	,	PUNCT
biomedich-1021	110	53	val466	val466	PROPN
biomedich-1021	110	54	,	,	PUNCT
biomedich-1021	110	55	tyr327	tyr327	PROPN
biomedich-1021	110	56	,	,	PUNCT
biomedich-1021	110	57	phe465	phe465	PROPN
biomedich-1021	110	58	(	(	PUNCT
biomedich-1021	110	59	2s)-5	2s)-5	PROPN
biomedich-1021	110	60	-	-	PUNCT
biomedich-1021	110	61	methoxy-6	methoxy-6	NUM
biomedich-1021	110	62	-	-	PUNCT
biomedich-1021	110	63	methylflavan-7	methylflavan-7	NOUN
biomedich-1021	110	64	-	-	PUNCT
biomedich-1021	110	65	ol	ol	NOUN
biomedich-1021	110	66	-7.7	-7.7	ADJ
biomedich-1021	110	67	gly303	gly303	PROPN
biomedich-1021	110	68	,	,	PUNCT
biomedich-1021	110	69	met53	met53	PROPN
biomedich-1021	110	70	,	,	PUNCT
biomedich-1021	110	71	cys310	cys310	PROPN
biomedich-1021	110	72	,	,	PUNCT
biomedich-1021	110	73	ala51	ala51	PROPN
biomedich-1021	110	74	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	111	1	c	c	PROPN
biomedich-1021	112	1	-7.5	-7.5	INTJ
biomedich-1021	112	2	met368	met368	PROPN
biomedich-1021	112	3	,	,	PUNCT
biomedich-1021	112	4	lys347	lys347	PROPN
biomedich-1021	112	5	,	,	PUNCT
biomedich-1021	112	6	pro488	pro488	PROPN
biomedich-1021	112	7	,	,	PUNCT
biomedich-1021	112	8	lys430	lys430	PROPN
biomedich-1021	112	9	,	,	PUNCT
biomedich-1021	112	10	tyr348	tyr348	NOUN
biomedich-1021	112	11	davidigenin	davidigenin	PROPN
biomedich-1021	112	12	-7.4	-7.4	PROPN
biomedich-1021	112	13	gly96	gly96	PROPN
biomedich-1021	112	14	,	,	PUNCT
biomedich-1021	112	15	gly124	gly124	PROPN
biomedich-1021	112	16	,	,	PUNCT
biomedich-1021	112	17	tyr120	tyr120	NOUN
biomedich-1021	112	18	,	,	PUNCT
biomedich-1021	112	19	val97	val97	PROPN
biomedich-1021	112	20	,	,	PUNCT
biomedich-1021	112	21	ile122	ile122	PROPN
biomedich-1021	112	22	,	,	PUNCT
biomedich-1021	112	23	lys187	lys187	PROPN
biomedich-1021	112	24	trans-3,5	trans-3,5	PROPN
biomedich-1021	112	25	-	-	PUNCT
biomedich-1021	112	26	dihydroxy-4'-methoxystilbene	dihydroxy-4'-methoxystilbene	NOUN
biomedich-1021	112	27	-7.4	-7.4	ADJ
biomedich-1021	112	28	ser308	ser308	PROPN
biomedich-1021	112	29	,	,	PUNCT
biomedich-1021	112	30	met53	met53	PROPN
biomedich-1021	112	31	,	,	PUNCT
biomedich-1021	112	32	cys310	cys310	PROPN
biomedich-1021	112	33	,	,	PUNCT
biomedich-1021	112	34	ala255	ala255	PROPN
biomedich-1021	112	35	4,4'-dihydroxy-2,6	4,4'-dihydroxy-2,6	NOUN
biomedich-1021	112	36	-	-	PUNCT
biomedich-1021	112	37	dimethoxydihydrochalcone	dimethoxydihydrochalcone	PROPN
biomedich-1021	112	38	-7.1	-7.1	INTJ
biomedich-1021	112	39	gly96	gly96	PROPN
biomedich-1021	112	40	,	,	PUNCT
biomedich-1021	112	41	lys204	lys204	PROPN
biomedich-1021	112	42	,	,	PUNCT
biomedich-1021	112	43	tyr120	tyr120	PROPN
biomedich-1021	112	44	,	,	PUNCT
biomedich-1021	112	45	gly124	gly124	PROPN
biomedich-1021	112	46	,	,	PUNCT
biomedich-1021	112	47	thr202	thr202	PROPN
biomedich-1021	112	48	,	,	PUNCT
biomedich-1021	112	49	lys187	lys187	PROPN
biomedich-1021	112	50	4'-hydroxy-2,6	4'-hydroxy-2,6	PROPN
biomedich-1021	112	51	-	-	PUNCT
biomedich-1021	112	52	dimethoxydihydrochalcone	dimethoxydihydrochalcone	NOUN
biomedich-1021	112	53	-6.7	-6.7	ADP
biomedich-1021	112	54	asp253	asp253	PROPN
biomedich-1021	112	55	,	,	PUNCT
biomedich-1021	112	56	cys310	cys310	PROPN
biomedich-1021	112	57	,	,	PUNCT
biomedich-1021	112	58	phe465	phe465	PROPN
biomedich-1021	112	59	,	,	PUNCT
biomedich-1021	112	60	tyr327	tyr327	PROPN
biomedich-1021	112	61	,	,	PUNCT
biomedich-1021	112	62	tyr13	tyr13	NOUN
biomedich-1021	112	63	residues	residue	NOUN
biomedich-1021	112	64	predominantly	predominantly	ADV
biomedich-1021	112	65	involved	involve	VERB
biomedich-1021	112	66	in	in	ADP
biomedich-1021	112	67	hydrogen	hydrogen	NOUN
biomedich-1021	112	68	bonding	bonding	NOUN
biomedich-1021	112	69	are	be	AUX
biomedich-1021	112	70	highlighted	highlight	VERB
biomedich-1021	112	71	in	in	ADP
biomedich-1021	112	72	bold	bold	ADJ
biomedich-1021	112	73	.	.	PUNCT
biomedich-1021	113	1	figure	figure	VERB
biomedich-1021	113	2	1	1	NUM
biomedich-1021	113	3	.	.	PUNCT
biomedich-1021	114	1	2d	2d	NUM
biomedich-1021	114	2	plots	plot	NOUN
biomedich-1021	114	3	illustrating	illustrate	VERB
biomedich-1021	114	4	the	the	DET
biomedich-1021	114	5	molecular	molecular	ADJ
biomedich-1021	114	6	interactions	interaction	NOUN
biomedich-1021	114	7	between	between	ADP
biomedich-1021	114	8	the	the	DET
biomedich-1021	114	9	top	top	ADJ
biomedich-1021	114	10	three	three	NUM
biomedich-1021	114	11	candidate	candidate	NOUN
biomedich-1021	114	12	compounds	compound	NOUN
biomedich-1021	114	13	and	and	CCONJ
biomedich-1021	114	14	the	the	DET
biomedich-1021	114	15	active	active	ADJ
biomedich-1021	114	16	site	site	NOUN
biomedich-1021	114	17	of	of	ADP
biomedich-1021	114	18	impdh	impdh	NOUN
biomedich-1021	114	19	(	(	PUNCT
biomedich-1021	114	20	1zfj	1zfj	NUM
biomedich-1021	114	21	)	)	PUNCT
biomedich-1021	114	22	.	.	PUNCT
biomedich-1021	115	1	the	the	DET
biomedich-1021	115	2	diagrams	diagram	NOUN
biomedich-1021	115	3	depict	depict	VERB
biomedich-1021	115	4	the	the	DET
biomedich-1021	115	5	binding	bind	VERB
biomedich-1021	115	6	modes	mode	NOUN
biomedich-1021	115	7	for	for	ADP
biomedich-1021	115	8	(	(	PUNCT
biomedich-1021	115	9	a	a	PRON
biomedich-1021	115	10	)	)	PUNCT
biomedich-1021	115	11	isopimaric	isopimaric	ADJ
biomedich-1021	115	12	acid	acid	NOUN
biomedich-1021	115	13	,	,	PUNCT
biomedich-1021	115	14	(	(	PUNCT
biomedich-1021	115	15	b	b	X
biomedich-1021	115	16	)	)	PUNCT
biomedich-1021	115	17	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	115	18	d	d	NOUN
biomedich-1021	115	19	,	,	PUNCT
biomedich-1021	115	20	and	and	CCONJ
biomedich-1021	115	21	(	(	PUNCT
biomedich-1021	115	22	c	c	X
biomedich-1021	115	23	)	)	PUNCT
biomedich-1021	115	24	2'-o	2'-o	NUM
biomedich-1021	115	25	methylisoliquiritigenin	methylisoliquiritigenin	NOUN
biomedich-1021	115	26	.	.	PUNCT
biomedich-1021	116	1	conventional	conventional	ADJ
biomedich-1021	116	2	hydrogen	hydrogen	NOUN
biomedich-1021	116	3	bonds	bond	NOUN
biomedich-1021	116	4	are	be	AUX
biomedich-1021	116	5	shown	show	VERB
biomedich-1021	116	6	as	as	ADP
biomedich-1021	116	7	green	green	ADJ
biomedich-1021	116	8	dashed	dash	VERB
biomedich-1021	116	9	lines	line	NOUN
biomedich-1021	116	10	with	with	ADP
biomedich-1021	116	11	arrows	arrow	NOUN
biomedich-1021	116	12	pointing	point	VERB
biomedich-1021	116	13	from	from	ADP
biomedich-1021	116	14	donor	donor	NOUN
biomedich-1021	116	15	to	to	ADP
biomedich-1021	116	16	acceptor	acceptor	NOUN
biomedich-1021	116	17	.	.	PUNCT
biomedich-1021	117	1	hydrophobic	hydrophobic	NOUN
biomedich-1021	117	2	interactions	interaction	NOUN
biomedich-1021	117	3	(	(	PUNCT
biomedich-1021	117	4	e.g.	e.g.	ADV
biomedich-1021	117	5	,	,	PUNCT
biomedich-1021	117	6	alkyl	alkyl	ADJ
biomedich-1021	117	7	,	,	PUNCT
biomedich-1021	117	8	pi	pi	NOUN
biomedich-1021	117	9	-	-	PUNCT
biomedich-1021	117	10	alkyl	alkyl	ADJ
biomedich-1021	117	11	)	)	PUNCT
biomedich-1021	117	12	are	be	AUX
biomedich-1021	117	13	represented	represent	VERB
biomedich-1021	117	14	by	by	ADP
biomedich-1021	117	15	light	light	ADJ
biomedich-1021	117	16	green	green	ADJ
biomedich-1021	117	17	splashes	splash	NOUN
biomedich-1021	117	18	.	.	PUNCT
biomedich-1021	118	1	key	key	ADJ
biomedich-1021	118	2	interacting	interact	VERB
biomedich-1021	118	3	amino	amino	NOUN
biomedich-1021	118	4	acid	acid	NOUN
biomedich-1021	118	5	residues	residue	NOUN
biomedich-1021	118	6	are	be	AUX
biomedich-1021	118	7	labeled	label	VERB
biomedich-1021	118	8	with	with	ADP
biomedich-1021	118	9	their	their	PRON
biomedich-1021	118	10	three	three	NUM
biomedich-1021	118	11	-	-	PUNCT
biomedich-1021	118	12	letter	letter	NOUN
biomedich-1021	118	13	code	code	NOUN
biomedich-1021	118	14	and	and	CCONJ
biomedich-1021	118	15	sequence	sequence	NOUN
biomedich-1021	118	16	number	number	NOUN
biomedich-1021	118	17	.	.	PUNCT
biomedich-1021	119	1	discussion	discussion	NOUN
biomedich-1021	119	2	the	the	DET
biomedich-1021	119	3	application	application	NOUN
biomedich-1021	119	4	of	of	ADP
biomedich-1021	119	5	a	a	DET
biomedich-1021	119	6	hierarchical	hierarchical	ADJ
biomedich-1021	119	7	virtual	virtual	ADJ
biomedich-1021	119	8	screening	screening	NOUN
biomedich-1021	119	9	workflow	workflow	NOUN
biomedich-1021	119	10	,	,	PUNCT
biomedich-1021	119	11	as	as	SCONJ
biomedich-1021	119	12	employed	employ	VERB
biomedich-1021	119	13	in	in	ADP
biomedich-1021	119	14	this	this	DET
biomedich-1021	119	15	study	study	NOUN
biomedich-1021	119	16	,	,	PUNCT
biomedich-1021	119	17	represents	represent	VERB
biomedich-1021	119	18	a	a	DET
biomedich-1021	119	19	rational	rational	ADJ
biomedich-1021	119	20	and	and	CCONJ
biomedich-1021	119	21	efficient	efficient	ADJ
biomedich-1021	119	22	strategy	strategy	NOUN
biomedich-1021	119	23	in	in	ADP
biomedich-1021	119	24	modern	modern	ADJ
biomedich-1021	119	25	drug	drug	NOUN
biomedich-1021	119	26	discovery	discovery	NOUN
biomedich-1021	119	27	(	(	PUNCT
biomedich-1021	119	28	van	van	PROPN
biomedich-1021	119	29	de	de	PROPN
biomedich-1021	119	30	waterbeemd	waterbeemd	PROPN
biomedich-1021	119	31	&	&	CCONJ
biomedich-1021	119	32	gifford	gifford	PROPN
biomedich-1021	119	33	,	,	PUNCT
biomedich-1021	119	34	2003	2003	NUM
biomedich-1021	119	35	)	)	PUNCT
biomedich-1021	119	36	.	.	PUNCT
biomedich-1021	120	1	by	by	ADP
biomedich-1021	120	2	first	first	ADV
biomedich-1021	120	3	filtering	filter	VERB
biomedich-1021	120	4	a	a	DET
biomedich-1021	120	5	compound	compound	NOUN
biomedich-1021	120	6	library	library	NOUN
biomedich-1021	120	7	based	base	VERB
biomedich-1021	120	8	on	on	ADP
biomedich-1021	120	9	fundamental	fundamental	ADJ
biomedich-1021	120	10	drug	drug	NOUN
biomedich-1021	120	11	-	-	PUNCT
biomedich-1021	120	12	like	like	ADJ
biomedich-1021	120	13	properties	property	NOUN
biomedich-1021	120	14	,	,	PUNCT
biomedich-1021	120	15	we	we	PRON
biomedich-1021	120	16	effectively	effectively	ADV
biomedich-1021	120	17	focused	focus	VERB
biomedich-1021	120	18	our	our	PRON
biomedich-1021	120	19	computational	computational	ADJ
biomedich-1021	120	20	efforts	effort	NOUN
biomedich-1021	120	21	on	on	ADP
biomedich-1021	120	22	candidates	candidate	NOUN
biomedich-1021	120	23	with	with	ADP
biomedich-1021	120	24	a	a	DET
biomedich-1021	120	25	higher	high	ADJ
biomedich-1021	120	26	intrinsic	intrinsic	ADJ
biomedich-1021	120	27	probability	probability	NOUN
biomedich-1021	120	28	of	of	ADP
biomedich-1021	120	29	success	success	NOUN
biomedich-1021	120	30	,	,	PUNCT
biomedich-1021	120	31	thereby	thereby	ADV
biomedich-1021	120	32	streamlining	streamline	VERB
biomedich-1021	120	33	the	the	DET
biomedich-1021	120	34	discovery	discovery	NOUN
biomedich-1021	120	35	process	process	NOUN
biomedich-1021	120	36	.	.	PUNCT
biomedich-1021	121	1	the	the	DET
biomedich-1021	121	2	initial	initial	ADJ
biomedich-1021	121	3	screening	screening	NOUN
biomedich-1021	121	4	using	use	VERB
biomedich-1021	121	5	lipinski	lipinski	PROPN
biomedich-1021	121	6	’s	’s	PART
biomedich-1021	121	7	rule	rule	NOUN
biomedich-1021	121	8	of	of	ADP
biomedich-1021	121	9	five	five	NUM
biomedich-1021	121	10	(	(	PUNCT
biomedich-1021	121	11	table	table	NOUN
biomedich-1021	121	12	1	1	NUM
biomedich-1021	121	13	)	)	PUNCT
biomedich-1021	121	14	proved	prove	VERB
biomedich-1021	121	15	to	to	PART
biomedich-1021	121	16	be	be	AUX
biomedich-1021	121	17	a	a	DET
biomedich-1021	121	18	decisive	decisive	ADJ
biomedich-1021	121	19	first	first	ADJ
biomedich-1021	121	20	step	step	NOUN
biomedich-1021	121	21	.	.	PUNCT
biomedich-1021	122	1	the	the	DET
biomedich-1021	122	2	exclusion	exclusion	NOUN
biomedich-1021	122	3	of	of	ADP
biomedich-1021	122	4	six	six	NUM
biomedich-1021	122	5	compounds	compound	NOUN
biomedich-1021	122	6	with	with	ADP
biomedich-1021	122	7	significant	significant	ADJ
biomedich-1021	122	8	physicochemical	physicochemical	ADJ
biomedich-1021	122	9	liabilities	liability	NOUN
biomedich-1021	122	10	allowed	allow	VERB
biomedich-1021	122	11	us	we	PRON
biomedich-1021	122	12	to	to	PART
biomedich-1021	122	13	concentrate	concentrate	VERB
biomedich-1021	122	14	on	on	ADP
biomedich-1021	122	15	11	11	NUM
biomedich-1021	122	16	candidates	candidate	NOUN
biomedich-1021	122	17	possessing	possess	VERB
biomedich-1021	122	18	more	more	ADV
biomedich-1021	122	19	favorable	favorable	ADJ
biomedich-1021	122	20	profiles	profile	NOUN
biomedich-1021	122	21	for	for	ADP
biomedich-1021	122	22	oral	oral	ADJ
biomedich-1021	122	23	administration	administration	NOUN
biomedich-1021	122	24	(	(	PUNCT
biomedich-1021	122	25	hughes	hughes	PROPN
biomedich-1021	122	26	et	et	PROPN
biomedich-1021	122	27	al	al	PROPN
biomedich-1021	122	28	.	.	PROPN
biomedich-1021	122	29	,	,	PUNCT
biomedich-1021	122	30	2011	2011	NUM
biomedich-1021	122	31	;	;	PUNCT
biomedich-1021	122	32	leeson	leeson	PROPN
biomedich-1021	122	33	&	&	CCONJ
biomedich-1021	122	34	springthorpe	springthorpe	PROPN
biomedich-1021	122	35	,	,	PUNCT
biomedich-1021	122	36	2007	2007	NUM
biomedich-1021	122	37	)	)	PUNCT
biomedich-1021	122	38	.	.	PUNCT
biomedich-1021	123	1	this	this	DET
biomedich-1021	123	2	approach	approach	NOUN
biomedich-1021	123	3	is	be	AUX
biomedich-1021	123	4	crucial	crucial	ADJ
biomedich-1021	123	5	for	for	ADP
biomedich-1021	123	6	mitigating	mitigate	VERB
biomedich-1021	123	7	the	the	DET
biomedich-1021	123	8	risk	risk	NOUN
biomedich-1021	123	9	of	of	ADP
biomedich-1021	123	10	late	late	ADJ
biomedich-1021	123	11	-	-	PUNCT
biomedich-1021	123	12	stage	stage	NOUN
biomedich-1021	123	13	failures	failure	NOUN
biomedich-1021	123	14	due	due	ADJ
biomedich-1021	123	15	to	to	ADP
biomedich-1021	123	16	poor	poor	ADJ
biomedich-1021	123	17	pharmacokinetics	pharmacokinetic	NOUN
biomedich-1021	123	18	(	(	PUNCT
biomedich-1021	123	19	kola	kola	PROPN
biomedich-1021	123	20	&	&	CCONJ
biomedich-1021	123	21	landis	landis	PROPN
biomedich-1021	123	22	,	,	PUNCT
biomedich-1021	123	23	2004	2004	NUM
biomedich-1021	123	24	)	)	PUNCT
biomedich-1021	123	25	.	.	PUNCT
biomedich-1021	124	1	among	among	ADP
biomedich-1021	124	2	the	the	DET
biomedich-1021	124	3	filtered	filter	VERB
biomedich-1021	124	4	candidates	candidate	NOUN
biomedich-1021	124	5	,	,	PUNCT
biomedich-1021	124	6	the	the	DET
biomedich-1021	124	7	molecular	molecular	ADJ
biomedich-1021	124	8	docking	docking	NOUN
biomedich-1021	124	9	results	result	NOUN
biomedich-1021	124	10	(	(	PUNCT
biomedich-1021	124	11	table	table	NOUN
biomedich-1021	124	12	2	2	NUM
biomedich-1021	124	13	)	)	PUNCT
biomedich-1021	124	14	provided	provide	VERB
biomedich-1021	124	15	strong	strong	ADJ
biomedich-1021	124	16	evidence	evidence	NOUN
biomedich-1021	124	17	of	of	ADP
biomedich-1021	124	18	potential	potential	ADJ
biomedich-1021	124	19	inhibitory	inhibitory	ADJ
biomedich-1021	124	20	activity	activity	NOUN
biomedich-1021	124	21	.	.	PUNCT
biomedich-1021	125	1	the	the	DET
biomedich-1021	125	2	high	high	ADJ
biomedich-1021	125	3	binding	bind	VERB
biomedich-1021	125	4	affinities	affinity	NOUN
biomedich-1021	125	5	of	of	ADP
biomedich-1021	125	6	isopimaric	isopimaric	ADJ
biomedich-1021	125	7	acid	acid	NOUN
biomedich-1021	125	8	(	(	PUNCT
biomedich-1021	125	9	−8.2	−8.2	PROPN
biomedich-1021	125	10	kcal	kcal	PROPN
biomedich-1021	125	11	/	/	SYM
biomedich-1021	125	12	mol	mol	NOUN
biomedich-1021	125	13	)	)	PUNCT
biomedich-1021	125	14	and	and	CCONJ
biomedich-1021	125	15	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	125	16	d	d	PROPN
biomedich-1021	125	17	(	(	PUNCT
biomedich-1021	125	18	−8.1	−8.1	PROPN
biomedich-1021	125	19	kcal	kcal	PROPN
biomedich-1021	125	20	/	/	SYM
biomedich-1021	125	21	mol	mol	NOUN
biomedich-1021	125	22	)	)	PUNCT
biomedich-1021	125	23	are	be	AUX
biomedich-1021	125	24	particularly	particularly	ADV
biomedich-1021	125	25	noteworthy	noteworthy	ADJ
biomedich-1021	125	26	.	.	PUNCT
biomedich-1021	126	1	the	the	DET
biomedich-1021	126	2	analysis	analysis	NOUN
biomedich-1021	126	3	of	of	ADP
biomedich-1021	126	4	their	their	PRON
biomedich-1021	126	5	binding	bind	VERB
biomedich-1021	126	6	modes	mode	NOUN
biomedich-1021	126	7	(	(	PUNCT
biomedich-1021	126	8	table	table	NOUN
biomedich-1021	126	9	5	5	NUM
biomedich-1021	126	10	and	and	CCONJ
biomedich-1021	126	11	figure	figure	NOUN
biomedich-1021	126	12	1	1	NUM
biomedich-1021	126	13	)	)	PUNCT
biomedich-1021	126	14	provides	provide	VERB
biomedich-1021	126	15	a	a	DET
biomedich-1021	126	16	structural	structural	ADJ
biomedich-1021	126	17	rationale	rationale	NOUN
biomedich-1021	126	18	for	for	ADP
biomedich-1021	126	19	this	this	DET
biomedich-1021	126	20	potency	potency	NOUN
biomedich-1021	126	21	.	.	PUNCT
biomedich-1021	127	1	the	the	DET
biomedich-1021	127	2	formation	formation	NOUN
biomedich-1021	127	3	of	of	ADP
biomedich-1021	127	4	specific	specific	ADJ
biomedich-1021	127	5	hydrogen	hydrogen	NOUN
biomedich-1021	127	6	bonds	bond	NOUN
biomedich-1021	127	7	and	and	CCONJ
biomedich-1021	127	8	hydrophobic	hydrophobic	NOUN
biomedich-1021	127	9	interactions	interaction	NOUN
biomedich-1021	127	10	with	with	ADP
biomedich-1021	127	11	key	key	ADJ
biomedich-1021	127	12	residues	residue	NOUN
biomedich-1021	127	13	within	within	ADP
biomedich-1021	127	14	the	the	DET
biomedich-1021	127	15	impdh	impdh	NOUN
biomedich-1021	127	16	active	active	ADJ
biomedich-1021	127	17	site	site	NOUN
biomedich-1021	127	18	suggests	suggest	VERB
biomedich-1021	127	19	a	a	DET
biomedich-1021	127	20	well	well	ADV
biomedich-1021	127	21	-	-	PUNCT
biomedich-1021	127	22	defined	define	VERB
biomedich-1021	127	23	mechanism	mechanism	NOUN
biomedich-1021	127	24	of	of	ADP
biomedich-1021	127	25	binding	bind	VERB
biomedich-1021	127	26	.	.	PUNCT
biomedich-1021	128	1	for	for	ADP
biomedich-1021	128	2	example	example	NOUN
biomedich-1021	128	3	,	,	PUNCT
biomedich-1021	128	4	the	the	DET
biomedich-1021	128	5	interactions	interaction	NOUN
biomedich-1021	128	6	of	of	ADP
biomedich-1021	128	7	isopimaric	isopimaric	ADJ
biomedich-1021	128	8	acid	acid	NOUN
biomedich-1021	128	9	with	with	ADP
biomedich-1021	128	10	thr312	thr312	PROPN
biomedich-1021	128	11	and	and	CCONJ
biomedich-1021	128	12	cys310	cys310	PROPN
biomedich-1021	128	13	are	be	AUX
biomedich-1021	128	14	significant	significant	ADJ
biomedich-1021	128	15	,	,	PUNCT
biomedich-1021	128	16	as	as	SCONJ
biomedich-1021	128	17	these	these	DET
biomedich-1021	128	18	residues	residue	NOUN
biomedich-1021	128	19	are	be	AUX
biomedich-1021	128	20	located	locate	VERB
biomedich-1021	128	21	in	in	ADP
biomedich-1021	128	22	regions	region	NOUN
biomedich-1021	128	23	critical	critical	ADJ
biomedich-1021	128	24	for	for	ADP
biomedich-1021	128	25	enzymatic	enzymatic	ADJ
biomedich-1021	128	26	function	function	NOUN
biomedich-1021	128	27	(	(	PUNCT
biomedich-1021	128	28	braun	braun	NOUN
biomedich-1021	128	29	-	-	PUNCT
biomedich-1021	128	30	sand	sand	NOUN
biomedich-1021	128	31	&	&	CCONJ
biomedich-1021	128	32	peetz	peetz	NOUN
biomedich-1021	128	33	,	,	PUNCT
biomedich-1021	128	34	2010	2010	NUM
biomedich-1021	128	35	)	)	PUNCT
biomedich-1021	128	36	.	.	PUNCT
biomedich-1021	129	1	however	however	ADV
biomedich-1021	129	2	,	,	PUNCT
biomedich-1021	129	3	high	high	ADJ
biomedich-1021	129	4	potency	potency	NOUN
biomedich-1021	129	5	must	must	AUX
biomedich-1021	129	6	be	be	AUX
biomedich-1021	129	7	balanced	balance	VERB
biomedich-1021	129	8	with	with	ADP
biomedich-1021	129	9	an	an	DET
biomedich-1021	129	10	acceptable	acceptable	ADJ
biomedich-1021	129	11	safety	safety	NOUN
biomedich-1021	129	12	and	and	CCONJ
biomedich-1021	129	13	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	129	14	profile	profile	NOUN
biomedich-1021	129	15	.	.	PUNCT
biomedich-1021	130	1	the	the	DET
biomedich-1021	130	2	admet	admet	PROPN
biomedich-1021	130	3	analysis	analysis	NOUN
biomedich-1021	130	4	(	(	PUNCT
biomedich-1021	130	5	table	table	NOUN
biomedich-1021	130	6	3	3	NUM
biomedich-1021	130	7	and	and	CCONJ
biomedich-1021	130	8	table	table	NOUN
biomedich-1021	130	9	4	4	NUM
biomedich-1021	130	10	)	)	PUNCT
biomedich-1021	130	11	was	be	AUX
biomedich-1021	130	12	instrumental	instrumental	ADJ
biomedich-1021	130	13	in	in	ADP
biomedich-1021	130	14	differentiating	differentiate	VERB
biomedich-1021	130	15	the	the	DET
biomedich-1021	130	16	top	top	ADV
biomedich-1021	130	17	-	-	PUNCT
biomedich-1021	130	18	binding	bind	VERB
biomedich-1021	130	19	compounds	compound	NOUN
biomedich-1021	130	20	.	.	PUNCT
biomedich-1021	131	1	here	here	ADV
biomedich-1021	131	2	,	,	PUNCT
biomedich-1021	131	3	isopimaric	isopimaric	NOUN
biomedich-1021	131	4	acid	acid	NOUN
biomedich-1021	131	5	clearly	clearly	ADV
biomedich-1021	131	6	distinguished	distinguish	VERB
biomedich-1021	131	7	itself	itself	PRON
biomedich-1021	131	8	as	as	ADP
biomedich-1021	131	9	a	a	DET
biomedich-1021	131	10	superior	superior	ADJ
biomedich-1021	131	11	lead	lead	NOUN
biomedich-1021	131	12	candidate	candidate	NOUN
biomedich-1021	131	13	.	.	PUNCT
biomedich-1021	132	1	it	it	PRON
biomedich-1021	132	2	not	not	PART
biomedich-1021	132	3	only	only	ADV
biomedich-1021	132	4	possesses	possess	VERB
biomedich-1021	132	5	the	the	DET
biomedich-1021	132	6	highest	high	ADJ
biomedich-1021	132	7	binding	bind	VERB
biomedich-1021	132	8	affinity	affinity	NOUN
biomedich-1021	132	9	but	but	CCONJ
biomedich-1021	132	10	also	also	ADV
biomedich-1021	132	11	exhibits	exhibit	VERB
biomedich-1021	132	12	an	an	DET
biomedich-1021	132	13	exemplary	exemplary	ADJ
biomedich-1021	132	14	predicted	predict	VERB
biomedich-1021	132	15	safety	safety	NOUN
biomedich-1021	132	16	profile	profile	NOUN
biomedich-1021	132	17	:	:	PUNCT
biomedich-1021	132	18	low	low	ADJ
biomedich-1021	132	19	acute	acute	NOUN
biomedich-1021	132	20	toxicity	toxicity	NOUN
biomedich-1021	132	21	(	(	PUNCT
biomedich-1021	132	22	class	class	NOUN
biomedich-1021	132	23	5	5	NUM
biomedich-1021	132	24	)	)	PUNCT
biomedich-1021	132	25	,	,	PUNCT
biomedich-1021	132	26	a	a	DET
biomedich-1021	132	27	non	non	ADJ
biomedich-1021	132	28	-	-	ADJ
biomedich-1021	132	29	mutagenic	mutagenic	ADJ
biomedich-1021	132	30	(	(	PUNCT
biomedich-1021	132	31	a	a	X
biomedich-1021	132	32	)	)	PUNCT
biomedich-1021	132	33	isopimaric	isopimaric	ADJ
biomedich-1021	132	34	acid	acid	NOUN
biomedich-1021	132	35	(	(	PUNCT
biomedich-1021	132	36	−8.2	−8.2	PROPN
biomedich-1021	132	37	kcal	kcal	PROPN
biomedich-1021	132	38	/	/	SYM
biomedich-1021	132	39	mol	mol	NOUN
biomedich-1021	132	40	)	)	PUNCT
biomedich-1021	132	41	(	(	PUNCT
biomedich-1021	132	42	b	b	X
biomedich-1021	132	43	)	)	PUNCT
biomedich-1021	132	44	cochinchinenene	cochinchinenene	NOUN
biomedich-1021	133	1	d	d	X
biomedich-1021	133	2	(	(	PUNCT
biomedich-1021	133	3	−8.1	−8.1	PROPN
biomedich-1021	133	4	kcal	kcal	PROPN
biomedich-1021	133	5	/	/	SYM
biomedich-1021	133	6	mol	mol	PROPN
biomedich-1021	133	7	)	)	PUNCT
biomedich-1021	133	8	(	(	PUNCT
biomedich-1021	133	9	c	c	X
biomedich-1021	133	10	)	)	PUNCT
biomedich-1021	133	11	2'-o	2'-o	NUM
biomedich-1021	133	12	methylisoliquiritigenin	methylisoliquiritigenin	ADV
biomedich-1021	133	13	(	(	PUNCT
biomedich-1021	133	14	−8.0	−8.0	PROPN
biomedich-1021	133	15	kcal	kcal	PROPN
biomedich-1021	133	16	/	/	SYM
biomedich-1021	133	17	mol	mol	PROPN
biomedich-1021	133	18	)	)	PUNCT
biomedich-1021	133	19	1270	1270	NUM
biomedich-1021	133	20	biology	biology	NOUN
biomedich-1021	133	21	,	,	PUNCT
biomedich-1021	133	22	medicine	medicine	NOUN
biomedich-1021	133	23	,	,	PUNCT
biomedich-1021	133	24	&	&	CCONJ
biomedich-1021	133	25	natural	natural	ADJ
biomedich-1021	133	26	product	product	NOUN
biomedich-1021	133	27	chemistry	chemistry	NOUN
biomedich-1021	133	28	14	14	NUM
biomedich-1021	133	29	(	(	PUNCT
biomedich-1021	133	30	2	2	NUM
biomedich-1021	133	31	)	)	PUNCT
biomedich-1021	133	32	,	,	PUNCT
biomedich-1021	133	33	2025	2025	NUM
biomedich-1021	133	34	:	:	PUNCT
biomedich-1021	133	35	1265	1265	NUM
biomedich-1021	133	36	-	-	SYM
biomedich-1021	133	37	1271	1271	NUM
biomedich-1021	133	38	prediction	prediction	NOUN
biomedich-1021	133	39	,	,	PUNCT
biomedich-1021	133	40	and	and	CCONJ
biomedich-1021	133	41	no	no	DET
biomedich-1021	133	42	risk	risk	NOUN
biomedich-1021	133	43	of	of	ADP
biomedich-1021	133	44	hepatotoxicity	hepatotoxicity	NOUN
biomedich-1021	133	45	(	(	PUNCT
biomedich-1021	133	46	dili	dili	PROPN
biomedich-1021	133	47	)	)	PUNCT
biomedich-1021	133	48	.	.	PUNCT
biomedich-1021	134	1	this	this	DET
biomedich-1021	134	2	combination	combination	NOUN
biomedich-1021	134	3	of	of	ADP
biomedich-1021	134	4	potent	potent	ADJ
biomedich-1021	134	5	activity	activity	NOUN
biomedich-1021	134	6	and	and	CCONJ
biomedich-1021	134	7	predicted	predict	VERB
biomedich-1021	134	8	safety	safety	NOUN
biomedich-1021	134	9	is	be	AUX
biomedich-1021	134	10	the	the	DET
biomedich-1021	134	11	hallmark	hallmark	NOUN
biomedich-1021	134	12	of	of	ADP
biomedich-1021	134	13	a	a	DET
biomedich-1021	134	14	promising	promising	ADJ
biomedich-1021	134	15	drug	drug	NOUN
biomedich-1021	134	16	candidate	candidate	NOUN
biomedich-1021	134	17	(	(	PUNCT
biomedich-1021	134	18	waring	ware	VERB
biomedich-1021	134	19	et	et	PROPN
biomedich-1021	134	20	al	al	PROPN
biomedich-1021	134	21	.	.	PROPN
biomedich-1021	134	22	,	,	PUNCT
biomedich-1021	134	23	2015	2015	NUM
biomedich-1021	134	24	)	)	PUNCT
biomedich-1021	134	25	.	.	PUNCT
biomedich-1021	135	1	in	in	ADP
biomedich-1021	135	2	contrast	contrast	NOUN
biomedich-1021	135	3	,	,	PUNCT
biomedich-1021	135	4	other	other	ADJ
biomedich-1021	135	5	potent	potent	ADJ
biomedich-1021	135	6	binders	binder	NOUN
biomedich-1021	135	7	like	like	ADP
biomedich-1021	135	8	cochinchinenene	cochinchinenene	PROPN
biomedich-1021	135	9	d	d	NOUN
biomedich-1021	135	10	,	,	PUNCT
biomedich-1021	135	11	while	while	SCONJ
biomedich-1021	135	12	showing	show	VERB
biomedich-1021	135	13	strong	strong	ADJ
biomedich-1021	135	14	target	target	NOUN
biomedich-1021	135	15	engagement	engagement	NOUN
biomedich-1021	135	16	,	,	PUNCT
biomedich-1021	135	17	were	be	AUX
biomedich-1021	135	18	flagged	flag	VERB
biomedich-1021	135	19	for	for	ADP
biomedich-1021	135	20	potential	potential	ADJ
biomedich-1021	135	21	dili	dili	NOUN
biomedich-1021	135	22	risk	risk	NOUN
biomedich-1021	135	23	(	(	PUNCT
biomedich-1021	135	24	table	table	NOUN
biomedich-1021	135	25	4	4	NUM
biomedich-1021	135	26	)	)	PUNCT
biomedich-1021	135	27	.	.	PUNCT
biomedich-1021	136	1	this	this	DET
biomedich-1021	136	2	finding	finding	NOUN
biomedich-1021	136	3	does	do	AUX
biomedich-1021	136	4	not	not	PART
biomedich-1021	136	5	outright	outright	ADV
biomedich-1021	136	6	disqualify	disqualify	VERB
biomedich-1021	136	7	them	they	PRON
biomedich-1021	136	8	but	but	CCONJ
biomedich-1021	136	9	indicates	indicate	VERB
biomedich-1021	136	10	that	that	SCONJ
biomedich-1021	136	11	they	they	PRON
biomedich-1021	136	12	may	may	AUX
biomedich-1021	136	13	carry	carry	VERB
biomedich-1021	136	14	a	a	DET
biomedich-1021	136	15	higher	high	ADJ
biomedich-1021	136	16	risk	risk	NOUN
biomedich-1021	136	17	of	of	ADP
biomedich-1021	136	18	adverse	adverse	ADJ
biomedich-1021	136	19	effects	effect	NOUN
biomedich-1021	136	20	and	and	CCONJ
biomedich-1021	136	21	would	would	AUX
biomedich-1021	136	22	require	require	VERB
biomedich-1021	136	23	careful	careful	ADJ
biomedich-1021	136	24	toxicological	toxicological	ADJ
biomedich-1021	136	25	evaluation	evaluation	NOUN
biomedich-1021	136	26	or	or	CCONJ
biomedich-1021	136	27	structural	structural	ADJ
biomedich-1021	136	28	modifications	modification	NOUN
biomedich-1021	136	29	to	to	PART
biomedich-1021	136	30	mitigate	mitigate	VERB
biomedich-1021	136	31	this	this	DET
biomedich-1021	136	32	liability	liability	NOUN
biomedich-1021	136	33	.	.	PUNCT
biomedich-1021	137	1	this	this	DET
biomedich-1021	137	2	comparative	comparative	ADJ
biomedich-1021	137	3	analysis	analysis	NOUN
biomedich-1021	137	4	demonstrates	demonstrate	VERB
biomedich-1021	137	5	the	the	DET
biomedich-1021	137	6	critical	critical	ADJ
biomedich-1021	137	7	importance	importance	NOUN
biomedich-1021	137	8	of	of	ADP
biomedich-1021	137	9	integrating	integrate	VERB
biomedich-1021	137	10	admet	admet	PROPN
biomedich-1021	137	11	profiling	profiling	NOUN
biomedich-1021	137	12	early	early	ADV
biomedich-1021	137	13	in	in	ADP
biomedich-1021	137	14	the	the	DET
biomedich-1021	137	15	discovery	discovery	NOUN
biomedich-1021	137	16	pipeline	pipeline	NOUN
biomedich-1021	137	17	to	to	PART
biomedich-1021	137	18	prioritize	prioritize	VERB
biomedich-1021	137	19	compounds	compound	NOUN
biomedich-1021	137	20	that	that	PRON
biomedich-1021	137	21	balance	balance	NOUN
biomedich-1021	137	22	efficacy	efficacy	NOUN
biomedich-1021	137	23	with	with	ADP
biomedich-1021	137	24	safety	safety	NOUN
biomedich-1021	137	25	(	(	PUNCT
biomedich-1021	137	26	van	van	PROPN
biomedich-1021	137	27	de	de	PROPN
biomedich-1021	137	28	waterbeemd	waterbeemd	PROPN
biomedich-1021	137	29	&	&	CCONJ
biomedich-1021	137	30	gifford	gifford	PROPN
biomedich-1021	137	31	,	,	PUNCT
biomedich-1021	137	32	2003	2003	NUM
biomedich-1021	137	33	)	)	PUNCT
biomedich-1021	137	34	.	.	PUNCT
biomedich-1021	138	1	while	while	SCONJ
biomedich-1021	138	2	these	these	PRON
biomedich-1021	138	3	in	in	ADP
biomedich-1021	138	4	silico	silico	NOUN
biomedich-1021	138	5	findings	finding	NOUN
biomedich-1021	138	6	are	be	AUX
biomedich-1021	138	7	highly	highly	ADV
biomedich-1021	138	8	encouraging	encouraging	ADJ
biomedich-1021	138	9	,	,	PUNCT
biomedich-1021	138	10	it	it	PRON
biomedich-1021	138	11	is	be	AUX
biomedich-1021	138	12	essential	essential	ADJ
biomedich-1021	138	13	to	to	PART
biomedich-1021	138	14	acknowledge	acknowledge	VERB
biomedich-1021	138	15	their	their	PRON
biomedich-1021	138	16	predictive	predictive	ADJ
biomedich-1021	138	17	nature	nature	NOUN
biomedich-1021	138	18	.	.	PUNCT
biomedich-1021	139	1	computational	computational	ADJ
biomedich-1021	139	2	models	model	NOUN
biomedich-1021	139	3	are	be	AUX
biomedich-1021	139	4	powerful	powerful	ADJ
biomedich-1021	139	5	tools	tool	NOUN
biomedich-1021	139	6	for	for	ADP
biomedich-1021	139	7	hypothesis	hypothesis	NOUN
biomedich-1021	139	8	generation	generation	NOUN
biomedich-1021	139	9	but	but	CCONJ
biomedich-1021	139	10	are	be	AUX
biomedich-1021	139	11	not	not	PART
biomedich-1021	139	12	a	a	DET
biomedich-1021	139	13	substitute	substitute	NOUN
biomedich-1021	139	14	for	for	ADP
biomedich-1021	139	15	empirical	empirical	ADJ
biomedich-1021	139	16	data	datum	NOUN
biomedich-1021	139	17	(	(	PUNCT
biomedich-1021	139	18	agu	agu	NOUN
biomedich-1021	139	19	et	et	PROPN
biomedich-1021	139	20	al	al	PROPN
biomedich-1021	139	21	.	.	PROPN
biomedich-1021	139	22	,	,	PUNCT
biomedich-1021	139	23	2023	2023	NUM
biomedich-1021	139	24	)	)	PUNCT
biomedich-1021	139	25	.	.	PUNCT
biomedich-1021	140	1	the	the	DET
biomedich-1021	140	2	next	next	ADJ
biomedich-1021	140	3	crucial	crucial	ADJ
biomedich-1021	140	4	phase	phase	NOUN
biomedich-1021	140	5	will	will	AUX
biomedich-1021	140	6	be	be	AUX
biomedich-1021	140	7	the	the	DET
biomedich-1021	140	8	experimental	experimental	ADJ
biomedich-1021	140	9	validation	validation	NOUN
biomedich-1021	140	10	of	of	ADP
biomedich-1021	140	11	these	these	DET
biomedich-1021	140	12	predictions	prediction	NOUN
biomedich-1021	140	13	.	.	PUNCT
biomedich-1021	141	1	this	this	PRON
biomedich-1021	141	2	should	should	AUX
biomedich-1021	141	3	involve	involve	VERB
biomedich-1021	141	4	in	in	ADP
biomedich-1021	141	5	vitro	vitro	X
biomedich-1021	141	6	assays	assay	NOUN
biomedich-1021	141	7	to	to	PART
biomedich-1021	141	8	confirm	confirm	VERB
biomedich-1021	141	9	the	the	DET
biomedich-1021	141	10	impdh	impdh	NOUN
biomedich-1021	141	11	inhibitory	inhibitory	ADJ
biomedich-1021	141	12	activity	activity	NOUN
biomedich-1021	141	13	of	of	ADP
biomedich-1021	141	14	the	the	DET
biomedich-1021	141	15	prioritized	prioritize	VERB
biomedich-1021	141	16	compounds	compound	NOUN
biomedich-1021	141	17	and	and	CCONJ
biomedich-1021	141	18	to	to	PART
biomedich-1021	141	19	determine	determine	VERB
biomedich-1021	141	20	their	their	PRON
biomedich-1021	141	21	minimum	minimum	ADJ
biomedich-1021	141	22	inhibitory	inhibitory	ADJ
biomedich-1021	141	23	concentrations	concentration	NOUN
biomedich-1021	141	24	(	(	PUNCT
biomedich-1021	141	25	mics	mic	NOUN
biomedich-1021	141	26	)	)	PUNCT
biomedich-1021	141	27	against	against	ADP
biomedich-1021	141	28	clinical	clinical	ADJ
biomedich-1021	141	29	isolates	isolate	NOUN
biomedich-1021	141	30	of	of	ADP
biomedich-1021	141	31	s.	s.	PROPN
biomedich-1021	141	32	pyogenes	pyogenes	PROPN
biomedich-1021	141	33	.	.	PUNCT
biomedich-1021	142	1	the	the	DET
biomedich-1021	142	2	compelling	compelling	ADJ
biomedich-1021	142	3	computational	computational	ADJ
biomedich-1021	142	4	profile	profile	NOUN
biomedich-1021	142	5	of	of	ADP
biomedich-1021	142	6	isopimaric	isopimaric	ADJ
biomedich-1021	142	7	acid	acid	NOUN
biomedich-1021	142	8	,	,	PUNCT
biomedich-1021	142	9	in	in	ADP
biomedich-1021	142	10	particular	particular	ADJ
biomedich-1021	142	11	,	,	PUNCT
biomedich-1021	142	12	provides	provide	VERB
biomedich-1021	142	13	a	a	DET
biomedich-1021	142	14	strong	strong	ADJ
biomedich-1021	142	15	justification	justification	NOUN
biomedich-1021	142	16	for	for	ADP
biomedich-1021	142	17	its	its	PRON
biomedich-1021	142	18	advancement	advancement	NOUN
biomedich-1021	142	19	into	into	ADP
biomedich-1021	142	20	these	these	DET
biomedich-1021	142	21	more	more	ADJ
biomedich-1021	142	22	resource	resource	NOUN
biomedich-1021	142	23	-	-	PUNCT
biomedich-1021	142	24	intensive	intensive	ADJ
biomedich-1021	142	25	stages	stage	NOUN
biomedich-1021	142	26	of	of	ADP
biomedich-1021	142	27	the	the	DET
biomedich-1021	142	28	drug	drug	NOUN
biomedich-1021	142	29	discovery	discovery	NOUN
biomedich-1021	142	30	process	process	NOUN
biomedich-1021	142	31	(	(	PUNCT
biomedich-1021	142	32	lionta	lionta	PROPN
biomedich-1021	142	33	et	et	PROPN
biomedich-1021	142	34	al	al	PROPN
biomedich-1021	142	35	.	.	PROPN
biomedich-1021	142	36	,	,	PUNCT
biomedich-1021	142	37	2014	2014	NUM
biomedich-1021	142	38	)	)	PUNCT
biomedich-1021	142	39	.	.	PUNCT
biomedich-1021	143	1	conclusions	conclusion	NOUN
biomedich-1021	143	2	this	this	PRON
biomedich-1021	143	3	in	in	ADP
biomedich-1021	143	4	silico	silico	NOUN
biomedich-1021	143	5	investigation	investigation	NOUN
biomedich-1021	143	6	has	have	AUX
biomedich-1021	143	7	successfully	successfully	ADV
biomedich-1021	143	8	employed	employ	VERB
biomedich-1021	143	9	a	a	DET
biomedich-1021	143	10	hierarchical	hierarchical	ADJ
biomedich-1021	143	11	virtual	virtual	ADJ
biomedich-1021	143	12	screening	screening	NOUN
biomedich-1021	143	13	workflow	workflow	NOUN
biomedich-1021	143	14	to	to	PART
biomedich-1021	143	15	explore	explore	VERB
biomedich-1021	143	16	the	the	DET
biomedich-1021	143	17	therapeutic	therapeutic	ADJ
biomedich-1021	143	18	potential	potential	NOUN
biomedich-1021	143	19	of	of	ADP
biomedich-1021	143	20	compounds	compound	NOUN
biomedich-1021	143	21	from	from	ADP
biomedich-1021	143	22	dracaena	dracaena	ADJ
biomedich-1021	143	23	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	143	24	against	against	ADP
biomedich-1021	143	25	streptococcus	streptococcus	NOUN
biomedich-1021	143	26	pyogenes	pyogene	NOUN
biomedich-1021	143	27	impdh	impdh	NOUN
biomedich-1021	143	28	.	.	PUNCT
biomedich-1021	144	1	through	through	ADP
biomedich-1021	144	2	a	a	DET
biomedich-1021	144	3	systematic	systematic	ADJ
biomedich-1021	144	4	evaluation	evaluation	NOUN
biomedich-1021	144	5	of	of	ADP
biomedich-1021	144	6	drug	drug	NOUN
biomedich-1021	144	7	-	-	PUNCT
biomedich-1021	144	8	likeness	likeness	NOUN
biomedich-1021	144	9	,	,	PUNCT
biomedich-1021	144	10	target	target	NOUN
biomedich-1021	144	11	affinity	affinity	NOUN
biomedich-1021	144	12	,	,	PUNCT
biomedich-1021	144	13	pharmacokinetics	pharmacokinetic	NOUN
biomedich-1021	144	14	,	,	PUNCT
biomedich-1021	144	15	and	and	CCONJ
biomedich-1021	144	16	safety	safety	NOUN
biomedich-1021	144	17	,	,	PUNCT
biomedich-1021	144	18	this	this	DET
biomedich-1021	144	19	study	study	NOUN
biomedich-1021	144	20	has	have	AUX
biomedich-1021	144	21	identified	identify	VERB
biomedich-1021	144	22	several	several	ADJ
biomedich-1021	144	23	promising	promising	ADJ
biomedich-1021	144	24	lead	lead	NOUN
biomedich-1021	144	25	candidates	candidate	NOUN
biomedich-1021	144	26	.	.	PUNCT
biomedich-1021	145	1	notably	notably	ADV
biomedich-1021	145	2	,	,	PUNCT
biomedich-1021	145	3	isopimaric	isopimaric	ADJ
biomedich-1021	145	4	acid	acid	NOUN
biomedich-1021	145	5	emerged	emerge	VERB
biomedich-1021	145	6	as	as	ADP
biomedich-1021	145	7	a	a	DET
biomedich-1021	145	8	superior	superior	ADJ
biomedich-1021	145	9	candidate	candidate	NOUN
biomedich-1021	145	10	,	,	PUNCT
biomedich-1021	145	11	distinguished	distinguish	VERB
biomedich-1021	145	12	by	by	ADP
biomedich-1021	145	13	its	its	PRON
biomedich-1021	145	14	potent	potent	ADJ
biomedich-1021	145	15	binding	bind	VERB
biomedich-1021	145	16	affinity	affinity	NOUN
biomedich-1021	145	17	for	for	ADP
biomedich-1021	145	18	the	the	DET
biomedich-1021	145	19	target	target	NOUN
biomedich-1021	145	20	enzyme	enzyme	NOUN
biomedich-1021	145	21	,	,	PUNCT
biomedich-1021	145	22	compliance	compliance	NOUN
biomedich-1021	145	23	with	with	ADP
biomedich-1021	145	24	key	key	ADJ
biomedich-1021	145	25	drug	drug	NOUN
biomedich-1021	145	26	-	-	PUNCT
biomedich-1021	145	27	like	like	ADJ
biomedich-1021	145	28	properties	property	NOUN
biomedich-1021	145	29	,	,	PUNCT
biomedich-1021	145	30	and	and	CCONJ
biomedich-1021	145	31	an	an	DET
biomedich-1021	145	32	excellent	excellent	ADJ
biomedich-1021	145	33	predicted	predict	VERB
biomedich-1021	145	34	safety	safety	NOUN
biomedich-1021	145	35	profile	profile	NOUN
biomedich-1021	145	36	free	free	ADJ
biomedich-1021	145	37	from	from	ADP
biomedich-1021	145	38	mutagenic	mutagenic	ADJ
biomedich-1021	145	39	and	and	CCONJ
biomedich-1021	145	40	hepatotoxic	hepatotoxic	ADJ
biomedich-1021	145	41	liabilities	liability	NOUN
biomedich-1021	145	42	.	.	PUNCT
biomedich-1021	146	1	these	these	DET
biomedich-1021	146	2	comprehensive	comprehensive	ADJ
biomedich-1021	146	3	computational	computational	ADJ
biomedich-1021	146	4	findings	finding	NOUN
biomedich-1021	146	5	strongly	strongly	ADV
biomedich-1021	146	6	support	support	VERB
biomedich-1021	146	7	the	the	DET
biomedich-1021	146	8	prioritization	prioritization	NOUN
biomedich-1021	146	9	of	of	ADP
biomedich-1021	146	10	isopimaric	isopimaric	ADJ
biomedich-1021	146	11	acid	acid	NOUN
biomedich-1021	146	12	for	for	ADP
biomedich-1021	146	13	subsequent	subsequent	ADJ
biomedich-1021	146	14	experimental	experimental	ADJ
biomedich-1021	146	15	validation	validation	NOUN
biomedich-1021	146	16	,	,	PUNCT
biomedich-1021	146	17	including	include	VERB
biomedich-1021	146	18	in	in	ADP
biomedich-1021	146	19	vitro	vitro	X
biomedich-1021	146	20	enzymatic	enzymatic	ADJ
biomedich-1021	146	21	and	and	CCONJ
biomedich-1021	146	22	antibacterial	antibacterial	ADJ
biomedich-1021	146	23	assays	assay	NOUN
biomedich-1021	146	24	,	,	PUNCT
biomedich-1021	146	25	to	to	PART
biomedich-1021	146	26	confirm	confirm	VERB
biomedich-1021	146	27	its	its	PRON
biomedich-1021	146	28	potential	potential	NOUN
biomedich-1021	146	29	as	as	ADP
biomedich-1021	146	30	a	a	DET
biomedich-1021	146	31	novel	novel	NOUN
biomedich-1021	146	32	scaffold	scaffold	NOUN
biomedich-1021	146	33	for	for	ADP
biomedich-1021	146	34	developing	develop	VERB
biomedich-1021	146	35	new	new	ADJ
biomedich-1021	146	36	antibacterial	antibacterial	ADJ
biomedich-1021	146	37	agents	agent	NOUN
biomedich-1021	146	38	against	against	ADP
biomedich-1021	146	39	s.	s.	PROPN
biomedich-1021	146	40	pyogenes	pyogenes	PROPN
biomedich-1021	146	41	.	.	PUNCT
biomedich-1021	147	1	acknowledgements	acknowledgement	NOUN
biomedich-1021	147	2	:	:	PUNCT
biomedich-1021	147	3	the	the	DET
biomedich-1021	147	4	authors	author	NOUN
biomedich-1021	147	5	would	would	AUX
biomedich-1021	147	6	like	like	VERB
biomedich-1021	147	7	to	to	PART
biomedich-1021	147	8	acknowledge	acknowledge	VERB
biomedich-1021	147	9	the	the	DET
biomedich-1021	147	10	developers	developer	NOUN
biomedich-1021	147	11	of	of	ADP
biomedich-1021	147	12	the	the	DET
biomedich-1021	147	13	computational	computational	ADJ
biomedich-1021	147	14	tools	tool	NOUN
biomedich-1021	147	15	and	and	CCONJ
biomedich-1021	147	16	databases	database	NOUN
biomedich-1021	147	17	used	use	VERB
biomedich-1021	147	18	in	in	ADP
biomedich-1021	147	19	this	this	DET
biomedich-1021	147	20	study	study	NOUN
biomedich-1021	147	21	,	,	PUNCT
biomedich-1021	147	22	including	include	VERB
biomedich-1021	147	23	autodock	autodock	NOUN
biomedich-1021	147	24	,	,	PUNCT
biomedich-1021	147	25	biovia	biovia	NOUN
biomedich-1021	147	26	discovery	discovery	PROPN
biomedich-1021	147	27	studio	studio	PROPN
biomedich-1021	147	28	,	,	PUNCT
biomedich-1021	147	29	pubchem	pubchem	NOUN
biomedich-1021	147	30	,	,	PUNCT
biomedich-1021	147	31	the	the	DET
biomedich-1021	147	32	protein	protein	NOUN
biomedich-1021	147	33	data	datum	NOUN
biomedich-1021	147	34	bank	bank	PROPN
biomedich-1021	147	35	,	,	PUNCT
biomedich-1021	147	36	pkcsm	pkcsm	NOUN
biomedich-1021	147	37	,	,	PUNCT
biomedich-1021	147	38	and	and	CCONJ
biomedich-1021	147	39	protox	protox	PROPN
biomedich-1021	147	40	-	-	PUNCT
biomedich-1021	147	41	ii	ii	NOUN
biomedich-1021	147	42	,	,	PUNCT
biomedich-1021	147	43	which	which	PRON
biomedich-1021	147	44	were	be	AUX
biomedich-1021	147	45	instrumental	instrumental	ADJ
biomedich-1021	147	46	in	in	ADP
biomedich-1021	147	47	conducting	conduct	VERB
biomedich-1021	147	48	this	this	DET
biomedich-1021	147	49	research	research	NOUN
biomedich-1021	147	50	.	.	PUNCT
biomedich-1021	148	1	authors	author	NOUN
biomedich-1021	148	2	’	'	PUNCT
biomedich-1021	148	3	contributions	contribution	NOUN
biomedich-1021	148	4	:	:	PUNCT
biomedich-1021	148	5	septi	septi	PROPN
biomedich-1021	148	6	handayani	handayani	PROPN
biomedich-1021	148	7	&	&	CCONJ
biomedich-1021	148	8	nawan	nawan	PROPN
biomedich-1021	148	9	designed	design	VERB
biomedich-1021	148	10	the	the	DET
biomedich-1021	148	11	study	study	NOUN
biomedich-1021	148	12	.	.	PUNCT
biomedich-1021	149	1	agnes	agnes	PROPN
biomedich-1021	149	2	immanuela	immanuela	PROPN
biomedich-1021	149	3	toemon	toemon	PROPN
biomedich-1021	149	4	carried	carry	VERB
biomedich-1021	149	5	out	out	ADP
biomedich-1021	149	6	the	the	DET
biomedich-1021	149	7	computational	computational	ADJ
biomedich-1021	149	8	work	work	NOUN
biomedich-1021	149	9	.	.	PUNCT
biomedich-1021	150	1	septi	septi	PROPN
biomedich-1021	150	2	handayani	handayani	PROPN
biomedich-1021	150	3	analyzed	analyze	VERB
biomedich-1021	150	4	the	the	DET
biomedich-1021	150	5	data	datum	NOUN
biomedich-1021	150	6	.	.	PUNCT
biomedich-1021	151	1	all	all	DET
biomedich-1021	151	2	authors	author	NOUN
biomedich-1021	151	3	wrote	write	VERB
biomedich-1021	151	4	the	the	DET
biomedich-1021	151	5	manuscript	manuscript	NOUN
biomedich-1021	151	6	.	.	PUNCT
biomedich-1021	152	1	all	all	DET
biomedich-1021	152	2	authors	author	NOUN
biomedich-1021	152	3	read	read	VERB
biomedich-1021	152	4	and	and	CCONJ
biomedich-1021	152	5	approved	approve	VERB
biomedich-1021	152	6	the	the	DET
biomedich-1021	152	7	final	final	ADJ
biomedich-1021	152	8	version	version	NOUN
biomedich-1021	152	9	of	of	ADP
biomedich-1021	152	10	the	the	DET
biomedich-1021	152	11	manuscript	manuscript	NOUN
biomedich-1021	152	12	.	.	PUNCT
biomedich-1021	153	1	competing	compete	VERB
biomedich-1021	153	2	interests	interest	NOUN
biomedich-1021	153	3	:	:	PUNCT
biomedich-1021	153	4	the	the	DET
biomedich-1021	153	5	authors	author	NOUN
biomedich-1021	153	6	declare	declare	VERB
biomedich-1021	153	7	that	that	SCONJ
biomedich-1021	153	8	there	there	PRON
biomedich-1021	153	9	are	be	VERB
biomedich-1021	153	10	no	no	DET
biomedich-1021	153	11	competing	compete	VERB
biomedich-1021	153	12	interests	interest	NOUN
biomedich-1021	153	13	.	.	PUNCT
biomedich-1021	154	1	funding	funding	NOUN
biomedich-1021	154	2	:	:	PUNCT
biomedich-1021	154	3	the	the	DET
biomedich-1021	154	4	authors	author	NOUN
biomedich-1021	154	5	declare	declare	VERB
biomedich-1021	154	6	no	no	DET
biomedich-1021	154	7	funding	funding	NOUN
biomedich-1021	154	8	was	be	AUX
biomedich-1021	154	9	received	receive	VERB
biomedich-1021	154	10	for	for	ADP
biomedich-1021	154	11	this	this	DET
biomedich-1021	154	12	research	research	NOUN
biomedich-1021	154	13	.	.	PUNCT
biomedich-1021	155	1	references	reference	NOUN
biomedich-1021	155	2	agu	agu	NOUN
biomedich-1021	155	3	,	,	PUNCT
biomedich-1021	155	4	p.	p.	PROPN
biomedich-1021	155	5	c.	c.	PROPN
biomedich-1021	155	6	,	,	PUNCT
biomedich-1021	155	7	afiukwa	afiukwa	PROPN
biomedich-1021	155	8	,	,	PUNCT
biomedich-1021	155	9	c.	c.	PROPN
biomedich-1021	155	10	a.	a.	PROPN
biomedich-1021	155	11	,	,	PUNCT
biomedich-1021	155	12	orji	orji	PROPN
biomedich-1021	155	13	,	,	PUNCT
biomedich-1021	155	14	o.	o.	PROPN
biomedich-1021	155	15	u.	u.	PROPN
biomedich-1021	155	16	,	,	PUNCT
biomedich-1021	155	17	ezeh	ezeh	PROPN
biomedich-1021	155	18	,	,	PUNCT
biomedich-1021	155	19	e.	e.	PROPN
biomedich-1021	155	20	m.	m.	PROPN
biomedich-1021	155	21	,	,	PUNCT
biomedich-1021	155	22	ofoke	ofoke	PROPN
biomedich-1021	155	23	,	,	PUNCT
biomedich-1021	155	24	i.	i.	PROPN
biomedich-1021	155	25	h.	h.	PROPN
biomedich-1021	155	26	,	,	PUNCT
biomedich-1021	155	27	ogbu	ogbu	ADV
biomedich-1021	155	28	,	,	PUNCT
biomedich-1021	155	29	c.	c.	PROPN
biomedich-1021	155	30	o.	o.	PROPN
biomedich-1021	155	31	,	,	PUNCT
biomedich-1021	155	32	ugwuja	ugwuja	PROPN
biomedich-1021	155	33	,	,	PUNCT
biomedich-1021	155	34	e.	e.	PROPN
biomedich-1021	155	35	i.	i.	PROPN
biomedich-1021	155	36	,	,	PUNCT
biomedich-1021	155	37	&	&	CCONJ
biomedich-1021	155	38	aja	aja	PROPN
biomedich-1021	155	39	,	,	PUNCT
biomedich-1021	155	40	p.	p.	NOUN
biomedich-1021	155	41	m.	m.	NOUN
biomedich-1021	155	42	(	(	PUNCT
biomedich-1021	155	43	2023	2023	NUM
biomedich-1021	155	44	)	)	PUNCT
biomedich-1021	155	45	.	.	PUNCT
biomedich-1021	156	1	molecular	molecular	ADJ
biomedich-1021	156	2	docking	docking	NOUN
biomedich-1021	156	3	as	as	ADP
biomedich-1021	156	4	a	a	DET
biomedich-1021	156	5	tool	tool	NOUN
biomedich-1021	156	6	for	for	ADP
biomedich-1021	156	7	the	the	DET
biomedich-1021	156	8	discovery	discovery	NOUN
biomedich-1021	156	9	of	of	ADP
biomedich-1021	156	10	molecular	molecular	ADJ
biomedich-1021	156	11	targets	target	NOUN
biomedich-1021	156	12	of	of	ADP
biomedich-1021	156	13	nutraceuticals	nutraceutical	NOUN
biomedich-1021	156	14	in	in	ADP
biomedich-1021	156	15	diseases	disease	NOUN
biomedich-1021	156	16	management	management	NOUN
biomedich-1021	156	17	.	.	PUNCT
biomedich-1021	157	1	scientific	scientific	ADJ
biomedich-1021	157	2	reports	report	NOUN
biomedich-1021	157	3	2023	2023	NUM
biomedich-1021	157	4	13:1	13:1	NUM
biomedich-1021	157	5	,	,	PUNCT
biomedich-1021	157	6	13(1	13(1	NUM
biomedich-1021	157	7	)	)	PUNCT
biomedich-1021	157	8	,	,	PUNCT
biomedich-1021	157	9	1–18	1–18	NUM
biomedich-1021	157	10	.	.	PUNCT
biomedich-1021	157	11	https://doi.org/10.1038/s41598-023-40160-2	https://doi.org/10.1038/s41598-023-40160-2	PROPN
biomedich-1021	157	12	ramanujan	ramanujan	PROPN
biomedich-1021	157	13	,	,	PUNCT
biomedich-1021	157	14	k.	k.	PROPN
biomedich-1021	157	15	(	(	PUNCT
biomedich-1021	157	16	2020	2020	NUM
biomedich-1021	157	17	,	,	PUNCT
biomedich-1021	157	18	june	june	PROPN
biomedich-1021	157	19	3	3	NUM
biomedich-1021	157	20	)	)	PUNCT
biomedich-1021	157	21	.	.	PUNCT
biomedich-1021	158	1	bacterial	bacterial	ADJ
biomedich-1021	158	2	enzyme	enzyme	NOUN
biomedich-1021	158	3	structure	structure	NOUN
biomedich-1021	158	4	opens	open	VERB
biomedich-1021	158	5	door	door	NOUN
biomedich-1021	158	6	for	for	ADP
biomedich-1021	158	7	new	new	ADJ
biomedich-1021	158	8	antibiotics	antibiotic	NOUN
biomedich-1021	158	9	.	.	PUNCT
biomedich-1021	159	1	cornell	cornell	PROPN
biomedich-1021	159	2	chronicle	chronicle	PROPN
biomedich-1021	159	3	.	.	PUNCT
biomedich-1021	160	1	https://news.cornell.edu/stories/2020/06/bacterial-enzymestructure-opens-door-new-antibiotics	https://news.cornell.edu/stories/2020/06/bacterial-enzymestructure-opens-door-new-antibiotics	PROPN
biomedich-1021	160	2	braun	braun	NOUN
biomedich-1021	160	3	-	-	PUNCT
biomedich-1021	160	4	sand	sand	NOUN
biomedich-1021	160	5	,	,	PUNCT
biomedich-1021	160	6	s.	s.	PROPN
biomedich-1021	160	7	b.	b.	PROPN
biomedich-1021	160	8	,	,	PUNCT
biomedich-1021	160	9	&	&	CCONJ
biomedich-1021	160	10	peetz	peetz	PROPN
biomedich-1021	160	11	,	,	PUNCT
biomedich-1021	160	12	m.	m.	NOUN
biomedich-1021	160	13	(	(	PUNCT
biomedich-1021	160	14	2010	2010	NUM
biomedich-1021	160	15	)	)	PUNCT
biomedich-1021	160	16	.	.	PUNCT
biomedich-1021	161	1	inosine	inosine	PROPN
biomedich-1021	161	2	monophosphate	monophosphate	NOUN
biomedich-1021	161	3	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	161	4	as	as	ADP
biomedich-1021	161	5	a	a	DET
biomedich-1021	161	6	target	target	NOUN
biomedich-1021	161	7	for	for	ADP
biomedich-1021	161	8	antiviral	antiviral	NOUN
biomedich-1021	161	9	,	,	PUNCT
biomedich-1021	161	10	anticancer	anticancer	NOUN
biomedich-1021	161	11	,	,	PUNCT
biomedich-1021	161	12	antimicrobial	antimicrobial	ADJ
biomedich-1021	161	13	and	and	CCONJ
biomedich-1021	161	14	immunosuppressive	immunosuppressive	ADJ
biomedich-1021	161	15	therapeutics	therapeutic	NOUN
biomedich-1021	161	16	.	.	PUNCT
biomedich-1021	162	1	future	future	ADJ
biomedich-1021	162	2	medicinal	medicinal	ADJ
biomedich-1021	162	3	chemistry	chemistry	NOUN
biomedich-1021	162	4	,	,	PUNCT
biomedich-1021	162	5	2(1	2(1	NUM
biomedich-1021	162	6	)	)	PUNCT
biomedich-1021	162	7	,	,	PUNCT
biomedich-1021	162	8	81–92	81–92	NUM
biomedich-1021	162	9	.	.	PUNCT
biomedich-1021	163	1	https://doi.org/10.4155/fmc.09.147	https://doi.org/10.4155/fmc.09.147	PROPN
biomedich-1021	163	2	buchwald	buchwald	NOUN
biomedich-1021	163	3	,	,	PUNCT
biomedich-1021	163	4	p.	p.	NOUN
biomedich-1021	163	5	(	(	PUNCT
biomedich-1021	163	6	2019	2019	NUM
biomedich-1021	163	7	)	)	PUNCT
biomedich-1021	163	8	.	.	PUNCT
biomedich-1021	164	1	a	a	DET
biomedich-1021	164	2	receptor	receptor	NOUN
biomedich-1021	164	3	model	model	NOUN
biomedich-1021	164	4	with	with	ADP
biomedich-1021	164	5	binding	bind	VERB
biomedich-1021	164	6	affinity	affinity	NOUN
biomedich-1021	164	7	,	,	PUNCT
biomedich-1021	164	8	activation	activation	NOUN
biomedich-1021	164	9	efficacy	efficacy	NOUN
biomedich-1021	164	10	,	,	PUNCT
biomedich-1021	164	11	and	and	CCONJ
biomedich-1021	164	12	signal	signal	ADJ
biomedich-1021	164	13	amplification	amplification	NOUN
biomedich-1021	164	14	parameters	parameter	NOUN
biomedich-1021	164	15	for	for	ADP
biomedich-1021	164	16	complex	complex	ADJ
biomedich-1021	164	17	fractional	fractional	ADJ
biomedich-1021	164	18	response	response	NOUN
biomedich-1021	164	19	versus	versus	ADP
biomedich-1021	164	20	occupancy	occupancy	NOUN
biomedich-1021	164	21	data	datum	NOUN
biomedich-1021	164	22	.	.	PUNCT
biomedich-1021	165	1	frontiers	frontier	NOUN
biomedich-1021	165	2	in	in	ADP
biomedich-1021	165	3	pharmacology	pharmacology	NOUN
biomedich-1021	165	4	,	,	PUNCT
biomedich-1021	165	5	10(jun	10(jun	PROPN
biomedich-1021	165	6	)	)	PUNCT
biomedich-1021	165	7	,	,	PUNCT
biomedich-1021	165	8	441435	441435	NUM
biomedich-1021	165	9	.	.	PUNCT
biomedich-1021	166	1	https://doi.org/10.3389/fphar.2019.00605/bibtex	https://doi.org/10.3389/fphar.2019.00605/bibtex	NOUN
biomedich-1021	166	2	cattoir	cattoir	PROPN
biomedich-1021	166	3	,	,	PUNCT
biomedich-1021	166	4	v.	v.	PROPN
biomedich-1021	166	5	(	(	PUNCT
biomedich-1021	166	6	2022	2022	NUM
biomedich-1021	166	7	)	)	PUNCT
biomedich-1021	166	8	.	.	PUNCT
biomedich-1021	167	1	mechanisms	mechanism	NOUN
biomedich-1021	167	2	of	of	ADP
biomedich-1021	167	3	streptococcus	streptococcus	NOUN
biomedich-1021	167	4	pyogenes	pyogene	NOUN
biomedich-1021	167	5	antibiotic	antibiotic	ADJ
biomedich-1021	167	6	resistance	resistance	NOUN
biomedich-1021	167	7	.	.	PUNCT
biomedich-1021	168	1	streptococcus	streptococcus	NOUN
biomedich-1021	168	2	pyogenes	pyogene	NOUN
biomedich-1021	168	3	:	:	PUNCT
biomedich-1021	168	4	basic	basic	ADJ
biomedich-1021	168	5	biology	biology	NOUN
biomedich-1021	168	6	to	to	ADP
biomedich-1021	168	7	clinical	clinical	ADJ
biomedich-1021	168	8	manifestations	manifestation	NOUN
biomedich-1021	168	9	.	.	PUNCT
biomedich-1021	169	1	https://www.ncbi.nlm.nih.gov/books/nbk587098/	https://www.ncbi.nlm.nih.gov/books/nbk587098/	PROPN
biomedich-1021	169	2	egbert	egbert	PROPN
biomedich-1021	169	3	,	,	PUNCT
biomedich-1021	169	4	m.	m.	NOUN
biomedich-1021	169	5	,	,	PUNCT
biomedich-1021	169	6	whitty	whitty	ADJ
biomedich-1021	169	7	,	,	PUNCT
biomedich-1021	169	8	a.	a.	NOUN
biomedich-1021	169	9	,	,	PUNCT
biomedich-1021	169	10	keserü	keserü	PROPN
biomedich-1021	169	11	,	,	PUNCT
biomedich-1021	169	12	g.	g.	PROPN
biomedich-1021	169	13	m.	m.	PROPN
biomedich-1021	169	14	,	,	PUNCT
biomedich-1021	169	15	&	&	CCONJ
biomedich-1021	169	16	vajda	vajda	PROPN
biomedich-1021	169	17	,	,	PUNCT
biomedich-1021	169	18	s.	s.	PROPN
biomedich-1021	169	19	(	(	PUNCT
biomedich-1021	169	20	2019	2019	NUM
biomedich-1021	169	21	)	)	PUNCT
biomedich-1021	169	22	.	.	PUNCT
biomedich-1021	170	1	why	why	SCONJ
biomedich-1021	170	2	some	some	DET
biomedich-1021	170	3	targets	target	NOUN
biomedich-1021	170	4	benefit	benefit	VERB
biomedich-1021	170	5	from	from	ADP
biomedich-1021	170	6	beyond	beyond	ADP
biomedich-1021	170	7	rule	rule	NOUN
biomedich-1021	170	8	of	of	ADP
biomedich-1021	170	9	five	five	NUM
biomedich-1021	170	10	drugs	drug	NOUN
biomedich-1021	170	11	.	.	PUNCT
biomedich-1021	171	1	journal	journal	NOUN
biomedich-1021	171	2	of	of	ADP
biomedich-1021	171	3	medicinal	medicinal	ADJ
biomedich-1021	171	4	chemistry	chemistry	NOUN
biomedich-1021	171	5	,	,	PUNCT
biomedich-1021	171	6	62(22	62(22	PROPN
biomedich-1021	171	7	)	)	PUNCT
biomedich-1021	171	8	,	,	PUNCT
biomedich-1021	171	9	10005	10005	NUM
biomedich-1021	171	10	.	.	PUNCT
biomedich-1021	172	1	https://doi.org/10.1021/acs.jmedchem.8b01732	https://doi.org/10.1021/acs.jmedchem.8b01732	NOUN
biomedich-1021	172	2	gupta	gupta	PROPN
biomedich-1021	172	3	,	,	PUNCT
biomedich-1021	172	4	d.	d.	PROPN
biomedich-1021	172	5	,	,	PUNCT
biomedich-1021	172	6	&	&	CCONJ
biomedich-1021	172	7	gupta	gupta	PROPN
biomedich-1021	172	8	,	,	PUNCT
biomedich-1021	172	9	r.	r.	PROPN
biomedich-1021	172	10	k.	k.	PROPN
biomedich-1021	172	11	(	(	PUNCT
biomedich-1021	172	12	2011	2011	NUM
biomedich-1021	172	13	)	)	PUNCT
biomedich-1021	172	14	.	.	PUNCT
biomedich-1021	173	1	bioprotective	bioprotective	ADJ
biomedich-1021	173	2	properties	property	NOUN
biomedich-1021	173	3	of	of	ADP
biomedich-1021	173	4	dragon	dragon	NOUN
biomedich-1021	173	5	’s	’s	PART
biomedich-1021	173	6	blood	blood	NOUN
biomedich-1021	173	7	resin	resin	NOUN
biomedich-1021	173	8	:	:	PUNCT
biomedich-1021	173	9	in	in	ADP
biomedich-1021	173	10	vitro	vitro	X
biomedich-1021	173	11	evaluation	evaluation	NOUN
biomedich-1021	173	12	of	of	ADP
biomedich-1021	173	13	antioxidant	antioxidant	ADJ
biomedich-1021	173	14	activity	activity	NOUN
biomedich-1021	173	15	and	and	CCONJ
biomedich-1021	173	16	antimicrobial	antimicrobial	ADJ
biomedich-1021	173	17	activity	activity	NOUN
biomedich-1021	173	18	.	.	PUNCT
biomedich-1021	174	1	bmc	bmc	PROPN
biomedich-1021	174	2	complementary	complementary	ADJ
biomedich-1021	174	3	and	and	CCONJ
biomedich-1021	174	4	alternative	alternative	ADJ
biomedich-1021	174	5	medicine	medicine	NOUN
biomedich-1021	174	6	,	,	PUNCT
biomedich-1021	174	7	11	11	NUM
biomedich-1021	174	8	.	.	X
biomedich-1021	175	1	https://doi.org/10.1186/1472-688211-13	https://doi.org/10.1186/1472-688211-13	NUM
biomedich-1021	175	2	he	he	PRON
biomedich-1021	175	3	,	,	PUNCT
biomedich-1021	175	4	t.	t.	PROPN
biomedich-1021	175	5	c.	c.	PROPN
biomedich-1021	175	6	,	,	PUNCT
biomedich-1021	175	7	wang	wang	PROPN
biomedich-1021	175	8	,	,	PUNCT
biomedich-1021	175	9	d.	d.	PROPN
biomedich-1021	175	10	w.	w.	PROPN
biomedich-1021	175	11	,	,	PUNCT
biomedich-1021	175	12	zheng	zheng	PROPN
biomedich-1021	175	13	,	,	PUNCT
biomedich-1021	175	14	s.	s.	PROPN
biomedich-1021	175	15	m.	m.	PROPN
biomedich-1021	175	16	,	,	PUNCT
biomedich-1021	175	17	yan	yan	PROPN
biomedich-1021	175	18	,	,	PUNCT
biomedich-1021	175	19	y.	y.	PROPN
biomedich-1021	175	20	m.	m.	PROPN
biomedich-1021	175	21	,	,	PUNCT
biomedich-1021	175	22	jiao	jiao	PROPN
biomedich-1021	175	23	,	,	PUNCT
biomedich-1021	175	24	y.	y.	PROPN
biomedich-1021	175	25	bin	bin	PROPN
biomedich-1021	175	26	,	,	PUNCT
biomedich-1021	175	27	cheng	cheng	PROPN
biomedich-1021	175	28	,	,	PUNCT
biomedich-1021	175	29	y.	y.	PROPN
biomedich-1021	175	30	x.	x.	PROPN
biomedich-1021	175	31	,	,	PUNCT
biomedich-1021	175	32	&	&	CCONJ
biomedich-1021	175	33	wang	wang	PROPN
biomedich-1021	175	34	,	,	PUNCT
biomedich-1021	175	35	f.	f.	PROPN
biomedich-1021	175	36	(	(	PUNCT
biomedich-1021	175	37	2021	2021	NUM
biomedich-1021	175	38	)	)	PUNCT
biomedich-1021	175	39	.	.	PUNCT
biomedich-1021	176	1	antifungal	antifungal	PROPN
biomedich-1021	176	2	and	and	CCONJ
biomedich-1021	176	3	wound	wound	VERB
biomedich-1021	176	4	healing	heal	VERB
biomedich-1021	176	5	promotive	promotive	ADJ
biomedich-1021	176	6	compounds	compound	NOUN
biomedich-1021	176	7	from	from	ADP
biomedich-1021	176	8	the	the	DET
biomedich-1021	176	9	resins	resin	NOUN
biomedich-1021	176	10	of	of	ADP
biomedich-1021	176	11	dracaena	dracaena	ADJ
biomedich-1021	176	12	cochinchinensis	cochinchinensis	NOUN
biomedich-1021	176	13	.	.	PUNCT
biomedich-1021	177	1	fitoterapia	fitoterapia	PROPN
biomedich-1021	177	2	,	,	PUNCT
biomedich-1021	177	3	151	151	NUM
biomedich-1021	177	4	,	,	PUNCT
biomedich-1021	177	5	104904	104904	NUM
biomedich-1021	177	6	.	.	PUNCT
biomedich-1021	178	1	https://doi.org/10.1016/j.fitote.2021.104904	https://doi.org/10.1016/j.fitote.2021.104904	VERB
biomedich-1021	178	2	hughes	hughes	PROPN
biomedich-1021	178	3	,	,	PUNCT
biomedich-1021	178	4	j.	j.	PROPN
biomedich-1021	178	5	p.	p.	PROPN
biomedich-1021	178	6	,	,	PUNCT
biomedich-1021	178	7	rees	rees	PROPN
biomedich-1021	178	8	,	,	PUNCT
biomedich-1021	178	9	s.	s.	PROPN
biomedich-1021	178	10	s.	s.	PROPN
biomedich-1021	178	11	,	,	PUNCT
biomedich-1021	178	12	kalindjian	kalindjian	PROPN
biomedich-1021	178	13	,	,	PUNCT
biomedich-1021	178	14	s.	s.	PROPN
biomedich-1021	178	15	b.	b.	PROPN
biomedich-1021	178	16	,	,	PUNCT
biomedich-1021	178	17	&	&	CCONJ
biomedich-1021	178	18	philpott	philpott	PROPN
biomedich-1021	178	19	,	,	PUNCT
biomedich-1021	178	20	k.	k.	PROPN
biomedich-1021	178	21	l.	l.	PROPN
biomedich-1021	178	22	(	(	PUNCT
biomedich-1021	178	23	2011	2011	NUM
biomedich-1021	178	24	)	)	PUNCT
biomedich-1021	178	25	.	.	PUNCT
biomedich-1021	179	1	principles	principle	NOUN
biomedich-1021	179	2	of	of	ADP
biomedich-1021	179	3	early	early	ADJ
biomedich-1021	179	4	drug	drug	NOUN
biomedich-1021	179	5	discovery	discovery	NOUN
biomedich-1021	179	6	.	.	PUNCT
biomedich-1021	180	1	british	british	ADJ
biomedich-1021	180	2	journal	journal	PROPN
biomedich-1021	180	3	of	of	ADP
biomedich-1021	180	4	pharmacology	pharmacology	NOUN
biomedich-1021	180	5	,	,	PUNCT
biomedich-1021	180	6	162(6	162(6	NUM
biomedich-1021	180	7	)	)	PUNCT
biomedich-1021	180	8	,	,	PUNCT
biomedich-1021	180	9	1239–1249	1239–1249	NUM
biomedich-1021	180	10	.	.	PUNCT
biomedich-1021	181	1	https://doi.org/10.1111/j.1476-5381.2010.01127.x	https://doi.org/10.1111/j.1476-5381.2010.01127.x	PROPN
biomedich-1021	181	2	kanwal	kanwal	PROPN
biomedich-1021	181	3	,	,	PUNCT
biomedich-1021	181	4	s.	s.	PROPN
biomedich-1021	181	5	,	,	PUNCT
biomedich-1021	181	6	&	&	CCONJ
biomedich-1021	181	7	vaitla	vaitla	PROPN
biomedich-1021	181	8	,	,	PUNCT
biomedich-1021	181	9	p.	p.	NOUN
biomedich-1021	181	10	(	(	PUNCT
biomedich-1021	181	11	2023	2023	NUM
biomedich-1021	181	12	)	)	PUNCT
biomedich-1021	181	13	.	.	PUNCT
biomedich-1021	182	1	streptococcus	streptococcus	NOUN
biomedich-1021	182	2	pyogenes	pyogene	NOUN
biomedich-1021	182	3	.	.	PUNCT
biomedich-1021	183	1	statpearls	statpearls	PROPN
biomedich-1021	183	2	.	.	PUNCT
biomedich-1021	184	1	https://www.ncbi.nlm.nih.gov/books/nbk554528/	https://www.ncbi.nlm.nih.gov/books/nbk554528/	PROPN
biomedich-1021	184	2	kebede	kebede	PROPN
biomedich-1021	184	3	,	,	PUNCT
biomedich-1021	184	4	d.	d.	PROPN
biomedich-1021	184	5	,	,	PUNCT
biomedich-1021	184	6	admas	admas	PROPN
biomedich-1021	184	7	,	,	PUNCT
biomedich-1021	184	8	a.	a.	NOUN
biomedich-1021	184	9	,	,	PUNCT
biomedich-1021	184	10	&	&	CCONJ
biomedich-1021	184	11	mekonnen	mekonnen	PROPN
biomedich-1021	184	12	,	,	PUNCT
biomedich-1021	184	13	d.	d.	PROPN
biomedich-1021	184	14	(	(	PUNCT
biomedich-1021	184	15	2021	2021	NUM
biomedich-1021	184	16	)	)	PUNCT
biomedich-1021	184	17	.	.	PUNCT
biomedich-1021	185	1	prevalence	prevalence	NOUN
biomedich-1021	185	2	and	and	CCONJ
biomedich-1021	185	3	antibiotics	antibiotic	NOUN
biomedich-1021	185	4	susceptibility	susceptibility	NOUN
biomedich-1021	185	5	profiles	profile	NOUN
biomedich-1021	185	6	of	of	ADP
biomedich-1021	185	7	streptococcus	streptococcus	NOUN
biomedich-1021	185	8	pyogenes	pyogene	NOUN
biomedich-1021	185	9	among	among	ADP
biomedich-1021	185	10	pediatric	pediatric	ADJ
biomedich-1021	185	11	patients	patient	NOUN
biomedich-1021	185	12	with	with	ADP
biomedich-1021	185	13	acute	acute	ADJ
biomedich-1021	185	14	pharyngitis	pharyngitis	NOUN
biomedich-1021	185	15	at	at	ADP
biomedich-1021	185	16	felege	felege	NOUN
biomedich-1021	185	17	hiwot	hiwot	PROPN
biomedich-1021	185	18	comprehensive	comprehensive	ADJ
biomedich-1021	185	19	specialized	specialized	ADJ
biomedich-1021	185	20	hospital	hospital	NOUN
biomedich-1021	185	21	,	,	PUNCT
biomedich-1021	185	22	northwest	northwest	PROPN
biomedich-1021	185	23	handayani	handayani	PROPN
biomedich-1021	185	24	et	et	PROPN
biomedich-1021	185	25	al	al	PROPN
biomedich-1021	185	26	.	.	PROPN
biomedich-1021	185	27	–	–	PUNCT
biomedich-1021	185	28	in	in	ADP
biomedich-1021	185	29	silico	silico	NOUN
biomedich-1021	185	30	inhibition	inhibition	NOUN
biomedich-1021	185	31	of	of	ADP
biomedich-1021	185	32	s.	s.	PROPN
biomedich-1021	185	33	pyogenes	pyogenes	PROPN
biomedich-1021	185	34	impdh	impdh	NOUN
biomedich-1021	185	35	1271	1271	NUM
biomedich-1021	185	36	ethiopia	ethiopia	PROPN
biomedich-1021	185	37	.	.	PUNCT
biomedich-1021	186	1	bmc	bmc	PROPN
biomedich-1021	186	2	microbiology	microbiology	NOUN
biomedich-1021	186	3	,	,	PUNCT
biomedich-1021	186	4	21(1	21(1	NUM
biomedich-1021	186	5	)	)	PUNCT
biomedich-1021	186	6	,	,	PUNCT
biomedich-1021	186	7	1–10	1–10	NOUN
biomedich-1021	186	8	.	.	PUNCT
biomedich-1021	187	1	https://doi.org/10.1186/s12866-021-02196-0/tables/3	https://doi.org/10.1186/s12866-021-02196-0/tables/3	PROPN
biomedich-1021	187	2	kola	kola	PROPN
biomedich-1021	187	3	,	,	PUNCT
biomedich-1021	187	4	i.	i.	PROPN
biomedich-1021	187	5	,	,	PUNCT
biomedich-1021	187	6	&	&	CCONJ
biomedich-1021	187	7	landis	landis	PROPN
biomedich-1021	187	8	,	,	PUNCT
biomedich-1021	187	9	j.	j.	PROPN
biomedich-1021	187	10	(	(	PUNCT
biomedich-1021	187	11	2004	2004	NUM
biomedich-1021	187	12	)	)	PUNCT
biomedich-1021	187	13	.	.	PUNCT
biomedich-1021	188	1	can	can	AUX
biomedich-1021	188	2	the	the	DET
biomedich-1021	188	3	pharmaceutical	pharmaceutical	NOUN
biomedich-1021	188	4	industry	industry	NOUN
biomedich-1021	188	5	reduce	reduce	VERB
biomedich-1021	188	6	attrition	attrition	NOUN
biomedich-1021	188	7	rates	rate	NOUN
biomedich-1021	188	8	?	?	PUNCT
biomedich-1021	189	1	nature	nature	NOUN
biomedich-1021	189	2	reviews	review	NOUN
biomedich-1021	189	3	.	.	PUNCT
biomedich-1021	190	1	drug	drug	NOUN
biomedich-1021	190	2	discovery	discovery	NOUN
biomedich-1021	190	3	,	,	PUNCT
biomedich-1021	190	4	3(8	3(8	NUM
biomedich-1021	190	5	)	)	PUNCT
biomedich-1021	190	6	,	,	PUNCT
biomedich-1021	190	7	711–715	711–715	NUM
biomedich-1021	190	8	.	.	PUNCT
biomedich-1021	191	1	https://doi.org/10.1038/nrd1470	https://doi.org/10.1038/nrd1470	PROPN
biomedich-1021	191	2	leeson	leeson	PROPN
biomedich-1021	191	3	,	,	PUNCT
biomedich-1021	191	4	p.	p.	PROPN
biomedich-1021	191	5	d.	d.	PROPN
biomedich-1021	191	6	,	,	PUNCT
biomedich-1021	191	7	&	&	CCONJ
biomedich-1021	191	8	springthorpe	springthorpe	PROPN
biomedich-1021	191	9	,	,	PUNCT
biomedich-1021	191	10	b.	b.	PROPN
biomedich-1021	191	11	(	(	PUNCT
biomedich-1021	191	12	2007	2007	NUM
biomedich-1021	191	13	)	)	PUNCT
biomedich-1021	191	14	.	.	PUNCT
biomedich-1021	192	1	the	the	DET
biomedich-1021	192	2	influence	influence	NOUN
biomedich-1021	192	3	of	of	ADP
biomedich-1021	192	4	druglike	druglike	NOUN
biomedich-1021	192	5	concepts	concept	NOUN
biomedich-1021	192	6	on	on	ADP
biomedich-1021	192	7	decision	decision	NOUN
biomedich-1021	192	8	-	-	PUNCT
biomedich-1021	192	9	making	making	NOUN
biomedich-1021	192	10	in	in	ADP
biomedich-1021	192	11	medicinal	medicinal	ADJ
biomedich-1021	192	12	chemistry	chemistry	NOUN
biomedich-1021	192	13	.	.	PUNCT
biomedich-1021	193	1	nature	nature	NOUN
biomedich-1021	193	2	reviews	review	VERB
biomedich-1021	193	3	drug	drug	NOUN
biomedich-1021	193	4	discovery	discovery	NOUN
biomedich-1021	193	5	,	,	PUNCT
biomedich-1021	193	6	6(11	6(11	NUM
biomedich-1021	193	7	)	)	PUNCT
biomedich-1021	193	8	,	,	PUNCT
biomedich-1021	193	9	881–890	881–890	NUM
biomedich-1021	193	10	.	.	PUNCT
biomedich-1021	194	1	https://doi.org/10.1038/nrd2445;kwrd	https://doi.org/10.1038/nrd2445;kwrd	PROPN
biomedich-1021	194	2	lionta	lionta	PROPN
biomedich-1021	194	3	,	,	PUNCT
biomedich-1021	194	4	e.	e.	PROPN
biomedich-1021	194	5	,	,	PUNCT
biomedich-1021	194	6	spyrou	spyrou	NOUN
biomedich-1021	194	7	,	,	PUNCT
biomedich-1021	194	8	g.	g.	PROPN
biomedich-1021	194	9	,	,	PUNCT
biomedich-1021	194	10	vassilatis	vassilatis	PROPN
biomedich-1021	194	11	,	,	PUNCT
biomedich-1021	194	12	d.	d.	PROPN
biomedich-1021	194	13	,	,	PUNCT
biomedich-1021	194	14	&	&	CCONJ
biomedich-1021	194	15	cournia	cournia	PROPN
biomedich-1021	194	16	,	,	PUNCT
biomedich-1021	194	17	z.	z.	PROPN
biomedich-1021	194	18	(	(	PUNCT
biomedich-1021	194	19	2014	2014	NUM
biomedich-1021	194	20	)	)	PUNCT
biomedich-1021	194	21	.	.	PUNCT
biomedich-1021	195	1	structure	structure	NOUN
biomedich-1021	195	2	-	-	PUNCT
biomedich-1021	195	3	based	base	VERB
biomedich-1021	195	4	virtual	virtual	ADJ
biomedich-1021	195	5	screening	screening	NOUN
biomedich-1021	195	6	for	for	ADP
biomedich-1021	195	7	drug	drug	NOUN
biomedich-1021	195	8	discovery	discovery	NOUN
biomedich-1021	195	9	:	:	PUNCT
biomedich-1021	195	10	principles	principle	NOUN
biomedich-1021	195	11	,	,	PUNCT
biomedich-1021	195	12	applications	application	NOUN
biomedich-1021	195	13	and	and	CCONJ
biomedich-1021	195	14	recent	recent	ADJ
biomedich-1021	195	15	advances	advance	NOUN
biomedich-1021	195	16	.	.	PUNCT
biomedich-1021	196	1	current	current	ADJ
biomedich-1021	196	2	topics	topic	NOUN
biomedich-1021	196	3	in	in	ADP
biomedich-1021	196	4	medicinal	medicinal	ADJ
biomedich-1021	196	5	chemistry	chemistry	NOUN
biomedich-1021	196	6	,	,	PUNCT
biomedich-1021	196	7	14(16	14(16	NUM
biomedich-1021	196	8	)	)	PUNCT
biomedich-1021	196	9	,	,	PUNCT
biomedich-1021	196	10	1923–1938	1923–1938	NUM
biomedich-1021	196	11	.	.	PUNCT
biomedich-1021	197	1	https://doi.org/10.2174/1568026614666140929124445	https://doi.org/10.2174/1568026614666140929124445	NOUN
biomedich-1021	197	2	lipinski	lipinski	PROPN
biomedich-1021	197	3	,	,	PUNCT
biomedich-1021	197	4	c.	c.	PROPN
biomedich-1021	197	5	a.	a.	PROPN
biomedich-1021	197	6	,	,	PUNCT
biomedich-1021	197	7	lombardo	lombardo	PROPN
biomedich-1021	197	8	,	,	PUNCT
biomedich-1021	197	9	f.	f.	PROPN
biomedich-1021	197	10	,	,	PUNCT
biomedich-1021	197	11	dominy	dominy	PROPN
biomedich-1021	197	12	,	,	PUNCT
biomedich-1021	197	13	b.	b.	PROPN
biomedich-1021	197	14	w.	w.	PROPN
biomedich-1021	197	15	,	,	PUNCT
biomedich-1021	197	16	&	&	CCONJ
biomedich-1021	197	17	feeney	feeney	PROPN
biomedich-1021	197	18	,	,	PUNCT
biomedich-1021	197	19	p.	p.	PROPN
biomedich-1021	197	20	j.	j.	PROPN
biomedich-1021	198	1	(	(	PUNCT
biomedich-1021	198	2	2001	2001	NUM
biomedich-1021	198	3	)	)	PUNCT
biomedich-1021	198	4	.	.	PUNCT
biomedich-1021	199	1	experimental	experimental	ADJ
biomedich-1021	199	2	and	and	CCONJ
biomedich-1021	199	3	computational	computational	ADJ
biomedich-1021	199	4	approaches	approach	NOUN
biomedich-1021	199	5	to	to	PART
biomedich-1021	199	6	estimate	estimate	VERB
biomedich-1021	199	7	solubility	solubility	NOUN
biomedich-1021	199	8	and	and	CCONJ
biomedich-1021	199	9	permeability	permeability	NOUN
biomedich-1021	199	10	in	in	ADP
biomedich-1021	199	11	drug	drug	NOUN
biomedich-1021	199	12	discovery	discovery	NOUN
biomedich-1021	199	13	and	and	CCONJ
biomedich-1021	199	14	development	development	NOUN
biomedich-1021	199	15	settings	setting	NOUN
biomedich-1021	199	16	.	.	PUNCT
biomedich-1021	200	1	advanced	advanced	ADJ
biomedich-1021	200	2	drug	drug	NOUN
biomedich-1021	200	3	delivery	delivery	NOUN
biomedich-1021	200	4	reviews	review	NOUN
biomedich-1021	200	5	,	,	PUNCT
biomedich-1021	200	6	46(1	46(1	NUM
biomedich-1021	200	7	–	–	PUNCT
biomedich-1021	200	8	3	3	NUM
biomedich-1021	200	9	)	)	PUNCT
biomedich-1021	200	10	,	,	PUNCT
biomedich-1021	200	11	3–26	3–26	NUM
biomedich-1021	200	12	.	.	PUNCT
biomedich-1021	201	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
biomedich-1021	201	2	modi	modi	PROPN
biomedich-1021	201	3	,	,	PUNCT
biomedich-1021	201	4	g.	g.	PROPN
biomedich-1021	201	5	,	,	PUNCT
biomedich-1021	201	6	marqus	marqus	PROPN
biomedich-1021	201	7	,	,	PUNCT
biomedich-1021	201	8	g.	g.	PROPN
biomedich-1021	201	9	m.	m.	PROPN
biomedich-1021	201	10	,	,	PUNCT
biomedich-1021	201	11	vippila	vippila	NOUN
biomedich-1021	201	12	,	,	PUNCT
biomedich-1021	201	13	m.	m.	NOUN
biomedich-1021	201	14	r.	r.	PROPN
biomedich-1021	201	15	,	,	PUNCT
biomedich-1021	201	16	gollapalli	gollapalli	PROPN
biomedich-1021	201	17	,	,	PUNCT
biomedich-1021	201	18	d.	d.	PROPN
biomedich-1021	201	19	r.	r.	PROPN
biomedich-1021	201	20	,	,	PUNCT
biomedich-1021	201	21	kim	kim	PROPN
biomedich-1021	201	22	,	,	PUNCT
biomedich-1021	201	23	y.	y.	PROPN
biomedich-1021	201	24	,	,	PUNCT
biomedich-1021	201	25	manna	manna	PROPN
biomedich-1021	201	26	,	,	PUNCT
biomedich-1021	201	27	a.	a.	PROPN
biomedich-1021	201	28	c.	c.	PROPN
biomedich-1021	201	29	,	,	PUNCT
biomedich-1021	201	30	chacko	chacko	NOUN
biomedich-1021	201	31	,	,	PUNCT
biomedich-1021	201	32	s.	s.	PROPN
biomedich-1021	201	33	,	,	PUNCT
biomedich-1021	201	34	maltseva	maltseva	PROPN
biomedich-1021	201	35	,	,	PUNCT
biomedich-1021	201	36	n.	n.	PROPN
biomedich-1021	201	37	,	,	PUNCT
biomedich-1021	201	38	wang	wang	PROPN
biomedich-1021	201	39	,	,	PUNCT
biomedich-1021	201	40	x.	x.	PROPN
biomedich-1021	201	41	,	,	PUNCT
biomedich-1021	201	42	cullinane	cullinane	PROPN
biomedich-1021	201	43	,	,	PUNCT
biomedich-1021	201	44	r.	r.	PROPN
biomedich-1021	201	45	t.	t.	PROPN
biomedich-1021	201	46	,	,	PUNCT
biomedich-1021	201	47	zhang	zhang	PROPN
biomedich-1021	201	48	,	,	PUNCT
biomedich-1021	201	49	y.	y.	PROPN
biomedich-1021	201	50	,	,	PUNCT
biomedich-1021	201	51	kotler	kotler	PROPN
biomedich-1021	201	52	,	,	PUNCT
biomedich-1021	201	53	j.	j.	PROPN
biomedich-1021	201	54	l.	l.	PROPN
biomedich-1021	201	55	m.	m.	PROPN
biomedich-1021	201	56	,	,	PUNCT
biomedich-1021	201	57	kuzmic	kuzmic	ADJ
biomedich-1021	201	58	,	,	PUNCT
biomedich-1021	201	59	p.	p.	PROPN
biomedich-1021	201	60	,	,	PUNCT
biomedich-1021	201	61	zhang	zhang	PROPN
biomedich-1021	201	62	,	,	PUNCT
biomedich-1021	201	63	m.	m.	NOUN
biomedich-1021	201	64	,	,	PUNCT
biomedich-1021	201	65	lawson	lawson	PROPN
biomedich-1021	201	66	,	,	PUNCT
biomedich-1021	201	67	a.	a.	NOUN
biomedich-1021	201	68	p.	p.	PROPN
biomedich-1021	201	69	,	,	PUNCT
biomedich-1021	201	70	joachimiak	joachimiak	PROPN
biomedich-1021	201	71	,	,	PUNCT
biomedich-1021	201	72	a.	a.	PROPN
biomedich-1021	201	73	,	,	PUNCT
biomedich-1021	201	74	cheung	cheung	PROPN
biomedich-1021	201	75	,	,	PUNCT
biomedich-1021	201	76	a.	a.	PROPN
biomedich-1021	201	77	,	,	PUNCT
biomedich-1021	201	78	snider	snider	PROPN
biomedich-1021	201	79	,	,	PUNCT
biomedich-1021	201	80	b.	b.	PROPN
biomedich-1021	201	81	b.	b.	PROPN
biomedich-1021	201	82	,	,	PUNCT
biomedich-1021	201	83	rothstein	rothstein	PROPN
biomedich-1021	201	84	,	,	PUNCT
biomedich-1021	201	85	d.	d.	PROPN
biomedich-1021	201	86	m.	m.	PROPN
biomedich-1021	201	87	,	,	PUNCT
biomedich-1021	201	88	…	…	PUNCT
biomedich-1021	201	89	hedstrom	hedstrom	NOUN
biomedich-1021	201	90	,	,	PUNCT
biomedich-1021	201	91	l.	l.	PROPN
biomedich-1021	201	92	(	(	PUNCT
biomedich-1021	201	93	2021	2021	NUM
biomedich-1021	201	94	)	)	PUNCT
biomedich-1021	201	95	.	.	PUNCT
biomedich-1021	202	1	the	the	DET
biomedich-1021	202	2	enzymatic	enzymatic	ADJ
biomedich-1021	202	3	activity	activity	NOUN
biomedich-1021	202	4	of	of	ADP
biomedich-1021	202	5	inosine	inosine	NOUN
biomedich-1021	202	6	5’-monophosphate	5’-monophosphate	NUM
biomedich-1021	202	7	dehydrogenase	dehydrogenase	NOUN
biomedich-1021	202	8	may	may	AUX
biomedich-1021	202	9	not	not	PART
biomedich-1021	202	10	be	be	AUX
biomedich-1021	202	11	a	a	DET
biomedich-1021	202	12	vulnerable	vulnerable	ADJ
biomedich-1021	202	13	target	target	NOUN
biomedich-1021	202	14	for	for	ADP
biomedich-1021	202	15	staphylococcus	staphylococcus	NOUN
biomedich-1021	202	16	aureus	aureus	NOUN
biomedich-1021	202	17	infections	infection	NOUN
biomedich-1021	202	18	.	.	PUNCT
biomedich-1021	203	1	acs	acs	PROPN
biomedich-1021	203	2	infectious	infectious	ADJ
biomedich-1021	203	3	diseases	disease	NOUN
biomedich-1021	203	4	,	,	PUNCT
biomedich-1021	203	5	7(11	7(11	NUM
biomedich-1021	203	6	)	)	PUNCT
biomedich-1021	203	7	,	,	PUNCT
biomedich-1021	203	8	3062	3062	NUM
biomedich-1021	203	9	.	.	PUNCT
biomedich-1021	204	1	https://doi.org/10.1021/acsinfecdis.1c00342	https://doi.org/10.1021/acsinfecdis.1c00342	PROPN
biomedich-1021	204	2	monteiro	monteiro	PROPN
biomedich-1021	204	3	,	,	PUNCT
biomedich-1021	204	4	n.	n.	PROPN
biomedich-1021	204	5	r.	r.	PROPN
biomedich-1021	204	6	c.	c.	PROPN
biomedich-1021	204	7	,	,	PUNCT
biomedich-1021	204	8	simões	simõe	VERB
biomedich-1021	204	9	,	,	PUNCT
biomedich-1021	204	10	c.	c.	PROPN
biomedich-1021	204	11	j.	j.	PROPN
biomedich-1021	204	12	v.	v.	PROPN
biomedich-1021	204	13	,	,	PUNCT
biomedich-1021	204	14	ávila	ávila	PROPN
biomedich-1021	204	15	,	,	PUNCT
biomedich-1021	204	16	h.	h.	PROPN
biomedich-1021	204	17	v.	v.	PROPN
biomedich-1021	204	18	,	,	PUNCT
biomedich-1021	204	19	abbasi	abbasi	PROPN
biomedich-1021	204	20	,	,	PUNCT
biomedich-1021	204	21	m.	m.	NOUN
biomedich-1021	204	22	,	,	PUNCT
biomedich-1021	204	23	oliveira	oliveira	PROPN
biomedich-1021	204	24	,	,	PUNCT
biomedich-1021	204	25	j.	j.	PROPN
biomedich-1021	204	26	l.	l.	PROPN
biomedich-1021	204	27	,	,	PUNCT
biomedich-1021	204	28	&	&	CCONJ
biomedich-1021	204	29	arrais	arrais	PROPN
biomedich-1021	204	30	,	,	PUNCT
biomedich-1021	204	31	j.	j.	PROPN
biomedich-1021	204	32	p.	p.	PROPN
biomedich-1021	204	33	(	(	PUNCT
biomedich-1021	204	34	2022	2022	NUM
biomedich-1021	204	35	)	)	PUNCT
biomedich-1021	204	36	.	.	PUNCT
biomedich-1021	205	1	explainable	explainable	ADJ
biomedich-1021	205	2	deep	deep	ADJ
biomedich-1021	205	3	drug	drug	NOUN
biomedich-1021	205	4	–	–	PUNCT
biomedich-1021	205	5	target	target	NOUN
biomedich-1021	205	6	representations	representation	NOUN
biomedich-1021	205	7	for	for	ADP
biomedich-1021	205	8	binding	bind	VERB
biomedich-1021	205	9	affinity	affinity	NOUN
biomedich-1021	205	10	prediction	prediction	NOUN
biomedich-1021	205	11	.	.	PUNCT
biomedich-1021	206	1	bmc	bmc	ADJ
biomedich-1021	206	2	bioinformatics	bioinformatics	PROPN
biomedich-1021	206	3	,	,	PUNCT
biomedich-1021	206	4	23(1	23(1	NOUN
biomedich-1021	206	5	)	)	PUNCT
biomedich-1021	206	6	,	,	PUNCT
biomedich-1021	206	7	1–24	1–24	PROPN
biomedich-1021	206	8	.	.	PUNCT
biomedich-1021	207	1	https://doi.org/10.1186/s12859022-04767-y/figures/10	https://doi.org/10.1186/s12859022-04767-y/figures/10	ADJ
biomedich-1021	207	2	nawan	nawan	PROPN
biomedich-1021	207	3	,	,	PUNCT
biomedich-1021	207	4	isnaeni	isnaeni	NOUN
biomedich-1021	207	5	,	,	PUNCT
biomedich-1021	207	6	&	&	CCONJ
biomedich-1021	207	7	wasito	wasito	PROPN
biomedich-1021	207	8	,	,	PUNCT
biomedich-1021	207	9	e.	e.	PROPN
biomedich-1021	207	10	b.	b.	PROPN
biomedich-1021	207	11	(	(	PUNCT
biomedich-1021	207	12	2020	2020	NUM
biomedich-1021	207	13	)	)	PUNCT
biomedich-1021	207	14	.	.	PUNCT
biomedich-1021	208	1	antimicrobial	antimicrobial	ADJ
biomedich-1021	208	2	activity	activity	NOUN
biomedich-1021	208	3	of	of	ADP
biomedich-1021	208	4	streptomyces	streptomyce	NOUN
biomedich-1021	208	5	sp	sp	NOUN
biomedich-1021	208	6	.	.	NOUN
biomedich-1021	208	7	isolated	isolate	VERB
biomedich-1021	208	8	from	from	ADP
biomedich-1021	208	9	acidic	acidic	ADJ
biomedich-1021	208	10	peatlands	peatland	NOUN
biomedich-1021	208	11	against	against	ADP
biomedich-1021	208	12	extended	extended	ADJ
biomedich-1021	208	13	spectrum	spectrum	NOUN
biomedich-1021	208	14	beta	beta	NOUN
biomedich-1021	208	15	lactamase	lactamase	NOUN
biomedich-1021	208	16	(	(	PUNCT
biomedich-1021	208	17	esbl	esbl	NOUN
biomedich-1021	208	18	)	)	PUNCT
biomedich-1021	208	19	producing	produce	VERB
biomedich-1021	208	20	escherichia	escherichia	NOUN
biomedich-1021	208	21	coli	coli	NOUN
biomedich-1021	208	22	.	.	PUNCT
biomedich-1021	209	1	research	research	NOUN
biomedich-1021	209	2	journal	journal	PROPN
biomedich-1021	209	3	of	of	ADP
biomedich-1021	209	4	pharmacy	pharmacy	NOUN
biomedich-1021	209	5	and	and	CCONJ
biomedich-1021	209	6	technology	technology	NOUN
biomedich-1021	209	7	,	,	PUNCT
biomedich-1021	209	8	13(3	13(3	NUM
biomedich-1021	209	9	)	)	PUNCT
biomedich-1021	209	10	,	,	PUNCT
biomedich-1021	209	11	1121–1126	1121–1126	NUM
biomedich-1021	209	12	.	.	PUNCT
biomedich-1021	210	1	https://doi.org/10.5958/0974360x.2020.00206.1	https://doi.org/10.5958/0974360x.2020.00206.1	NOUN
biomedich-1021	210	2	nawan	nawan	NOUN
biomedich-1021	210	3	,	,	PUNCT
biomedich-1021	210	4	n.	n.	NOUN
biomedich-1021	210	5	,	,	PUNCT
biomedich-1021	210	6	&	&	CCONJ
biomedich-1021	210	7	handayani	handayani	PROPN
biomedich-1021	210	8	,	,	PUNCT
biomedich-1021	210	9	septi	septi	NOUN
biomedich-1021	210	10	.	.	PUNCT
biomedich-1021	211	1	(	(	PUNCT
biomedich-1021	211	2	2021	2021	NUM
biomedich-1021	211	3	)	)	PUNCT
biomedich-1021	211	4	.	.	PUNCT
biomedich-1021	212	1	molecular	molecular	ADJ
biomedich-1021	212	2	identification	identification	NOUN
biomedich-1021	212	3	of	of	ADP
biomedich-1021	212	4	streptomyces	streptomyce	NOUN
biomedich-1021	212	5	sp	sp	NOUN
biomedich-1021	212	6	.	.	NOUN
biomedich-1021	212	7	isolated	isolate	VERB
biomedich-1021	212	8	from	from	ADP
biomedich-1021	212	9	peat	peat	NOUN
biomedich-1021	212	10	land	land	NOUN
biomedich-1021	212	11	of	of	ADP
biomedich-1021	212	12	palangka	palangka	PROPN
biomedich-1021	212	13	raya	raya	PROPN
biomedich-1021	212	14	,	,	PUNCT
biomedich-1021	212	15	kalimantan	kalimantan	PROPN
biomedich-1021	212	16	tengah	tengah	PROPN
biomedich-1021	212	17	using	use	VERB
biomedich-1021	212	18	16s	16s	PROPN
biomedich-1021	212	19	rrna	rrna	PROPN
biomedich-1021	212	20	gene	gene	NOUN
biomedich-1021	212	21	sequences	sequence	NOUN
biomedich-1021	212	22	analysis	analysis	NOUN
biomedich-1021	212	23	.	.	PUNCT
biomedich-1021	213	1	research	research	NOUN
biomedich-1021	213	2	journal	journal	PROPN
biomedich-1021	213	3	of	of	ADP
biomedich-1021	213	4	pharmacy	pharmacy	NOUN
biomedich-1021	213	5	and	and	CCONJ
biomedich-1021	213	6	technology	technology	NOUN
biomedich-1021	213	7	,	,	PUNCT
biomedich-1021	213	8	6639–6644	6639–6644	NUM
biomedich-1021	213	9	.	.	PUNCT
biomedich-1021	214	1	https://doi.org/10.52711/0974-360x.2021.01147	https://doi.org/10.52711/0974-360x.2021.01147	PROPN
biomedich-1021	214	2	nhlapho	nhlapho	NOUN
biomedich-1021	214	3	,	,	PUNCT
biomedich-1021	214	4	s.	s.	PROPN
biomedich-1021	214	5	,	,	PUNCT
biomedich-1021	214	6	nyathi	nyathi	PROPN
biomedich-1021	214	7	,	,	PUNCT
biomedich-1021	214	8	m.	m.	NOUN
biomedich-1021	214	9	,	,	PUNCT
biomedich-1021	214	10	ngwenya	ngwenya	PROPN
biomedich-1021	214	11	,	,	PUNCT
biomedich-1021	214	12	b.	b.	PROPN
biomedich-1021	214	13	,	,	PUNCT
biomedich-1021	214	14	dube	dube	PROPN
biomedich-1021	214	15	,	,	PUNCT
biomedich-1021	214	16	t.	t.	PROPN
biomedich-1021	214	17	,	,	PUNCT
biomedich-1021	214	18	telukdarie	telukdarie	NUM
biomedich-1021	214	19	,	,	PUNCT
biomedich-1021	214	20	a.	a.	NOUN
biomedich-1021	214	21	,	,	PUNCT
biomedich-1021	214	22	munien	munien	PROPN
biomedich-1021	214	23	,	,	PUNCT
biomedich-1021	214	24	i.	i.	PROPN
biomedich-1021	214	25	,	,	PUNCT
biomedich-1021	214	26	vermeulen	vermeulen	PROPN
biomedich-1021	214	27	,	,	PUNCT
biomedich-1021	214	28	a.	a.	PROPN
biomedich-1021	214	29	,	,	PUNCT
biomedich-1021	214	30	&	&	CCONJ
biomedich-1021	214	31	chude	chude	NOUN
biomedich-1021	214	32	-	-	PUNCT
biomedich-1021	214	33	okonkwo	okonkwo	NOUN
biomedich-1021	214	34	,	,	PUNCT
biomedich-1021	214	35	u.	u.	NOUN
biomedich-1021	214	36	(	(	PUNCT
biomedich-1021	214	37	2024	2024	NUM
biomedich-1021	214	38	)	)	PUNCT
biomedich-1021	214	39	.	.	PUNCT
biomedich-1021	215	1	druggability	druggability	NOUN
biomedich-1021	215	2	of	of	ADP
biomedich-1021	215	3	pharmaceutical	pharmaceutical	NOUN
biomedich-1021	215	4	compounds	compound	NOUN
biomedich-1021	215	5	using	use	VERB
biomedich-1021	215	6	lipinski	lipinski	PROPN
biomedich-1021	215	7	rules	rule	NOUN
biomedich-1021	215	8	with	with	ADP
biomedich-1021	215	9	machine	machine	NOUN
biomedich-1021	215	10	learning	learning	NOUN
biomedich-1021	215	11	.	.	PUNCT
biomedich-1021	216	1	sciences	science	NOUN
biomedich-1021	216	2	of	of	ADP
biomedich-1021	216	3	pharmacy	pharmacy	NOUN
biomedich-1021	216	4	,	,	PUNCT
biomedich-1021	216	5	3(4	3(4	NUM
biomedich-1021	216	6	)	)	PUNCT
biomedich-1021	216	7	,	,	PUNCT
biomedich-1021	216	8	177–192	177–192	NUM
biomedich-1021	216	9	.	.	PUNCT
biomedich-1021	216	10	https://doi.org/10.58920/sciphar0304264	https://doi.org/10.58920/sciphar0304264	NOUN
biomedich-1021	216	11	pires	pire	NOUN
biomedich-1021	216	12	,	,	PUNCT
biomedich-1021	216	13	d.	d.	PROPN
biomedich-1021	216	14	e.	e.	PROPN
biomedich-1021	216	15	v.	v.	PROPN
biomedich-1021	216	16	,	,	PUNCT
biomedich-1021	216	17	blundell	blundell	PROPN
biomedich-1021	216	18	,	,	PUNCT
biomedich-1021	216	19	t.	t.	PROPN
biomedich-1021	216	20	l.	l.	PROPN
biomedich-1021	216	21	,	,	PUNCT
biomedich-1021	216	22	&	&	CCONJ
biomedich-1021	216	23	ascher	ascher	PROPN
biomedich-1021	216	24	,	,	PUNCT
biomedich-1021	216	25	d.	d.	PROPN
biomedich-1021	216	26	b.	b.	PROPN
biomedich-1021	216	27	(	(	PUNCT
biomedich-1021	216	28	2015	2015	NUM
biomedich-1021	216	29	)	)	PUNCT
biomedich-1021	216	30	.	.	PUNCT
biomedich-1021	217	1	pkcsm	pkcsm	NOUN
biomedich-1021	217	2	:	:	PUNCT
biomedich-1021	217	3	predicting	predict	VERB
biomedich-1021	217	4	small	small	ADJ
biomedich-1021	217	5	-	-	PUNCT
biomedich-1021	217	6	molecule	molecule	NOUN
biomedich-1021	217	7	pharmacokinetic	pharmacokinetic	ADJ
biomedich-1021	217	8	and	and	CCONJ
biomedich-1021	217	9	toxicity	toxicity	NOUN
biomedich-1021	217	10	properties	property	NOUN
biomedich-1021	217	11	using	use	VERB
biomedich-1021	217	12	graph	graph	NOUN
biomedich-1021	217	13	-	-	PUNCT
biomedich-1021	217	14	based	base	VERB
biomedich-1021	217	15	signatures	signature	NOUN
biomedich-1021	217	16	.	.	PUNCT
biomedich-1021	218	1	journal	journal	NOUN
biomedich-1021	218	2	of	of	ADP
biomedich-1021	218	3	medicinal	medicinal	ADJ
biomedich-1021	218	4	chemistry	chemistry	NOUN
biomedich-1021	218	5	,	,	PUNCT
biomedich-1021	218	6	58(9	58(9	NOUN
biomedich-1021	218	7	)	)	PUNCT
biomedich-1021	218	8	,	,	PUNCT
biomedich-1021	218	9	4066–4072	4066–4072	NUM
biomedich-1021	218	10	.	.	PUNCT
biomedich-1021	219	1	https://doi.org/10.1021/acs.jmedchem.5b00104/suppl	https://doi.org/10.1021/acs.jmedchem.5b00104/suppl	PROPN
biomedich-1021	219	2	_	_	PRON
biomedich-1021	219	3	file	file	NOUN
biomedich-1021	219	4	/	/	SYM
biomedich-1021	219	5	jm5b00104_si_001.pdf	jm5b00104_si_001.pdf	NOUN
biomedich-1021	219	6	ünübol	ünübol	NOUN
biomedich-1021	219	7	,	,	PUNCT
biomedich-1021	219	8	n.	n.	NOUN
biomedich-1021	219	9	,	,	PUNCT
biomedich-1021	219	10	caglayan	caglayan	NOUN
biomedich-1021	219	11	,	,	PUNCT
biomedich-1021	219	12	n.	n.	NOUN
biomedich-1021	219	13	,	,	PUNCT
biomedich-1021	219	14	cebeci	cebeci	PROPN
biomedich-1021	219	15	,	,	PUNCT
biomedich-1021	219	16	s.	s.	PROPN
biomedich-1021	219	17	,	,	PUNCT
biomedich-1021	219	18	beşli	beşli	PROPN
biomedich-1021	219	19	,	,	PUNCT
biomedich-1021	219	20	y.	y.	PROPN
biomedich-1021	219	21	,	,	PUNCT
biomedich-1021	219	22	sancak	sancak	PROPN
biomedich-1021	219	23	,	,	PUNCT
biomedich-1021	219	24	b.	b.	PROPN
biomedich-1021	219	25	,	,	PUNCT
biomedich-1021	219	26	uyar	uyar	PROPN
biomedich-1021	219	27	,	,	PUNCT
biomedich-1021	219	28	n.	n.	PROPN
biomedich-1021	219	29	y.	y.	PROPN
biomedich-1021	219	30	,	,	PUNCT
biomedich-1021	219	31	ahrabi	ahrabi	PROPN
biomedich-1021	219	32	,	,	PUNCT
biomedich-1021	219	33	s.	s.	PROPN
biomedich-1021	219	34	s.	s.	PROPN
biomedich-1021	219	35	,	,	PUNCT
biomedich-1021	219	36	alebouyeh	alebouyeh	PROPN
biomedich-1021	219	37	,	,	PUNCT
biomedich-1021	219	38	m.	m.	NOUN
biomedich-1021	219	39	,	,	PUNCT
biomedich-1021	219	40	&	&	CCONJ
biomedich-1021	219	41	kocagöz	kocagöz	PROPN
biomedich-1021	219	42	,	,	PUNCT
biomedich-1021	219	43	t.	t.	PROPN
biomedich-1021	219	44	(	(	PUNCT
biomedich-1021	219	45	2025	2025	NUM
biomedich-1021	219	46	)	)	PUNCT
biomedich-1021	219	47	.	.	PUNCT
biomedich-1021	220	1	antimicrobial	antimicrobial	ADJ
biomedich-1021	220	2	resistance	resistance	NOUN
biomedich-1021	220	3	and	and	CCONJ
biomedich-1021	220	4	epidemiological	epidemiological	ADJ
biomedich-1021	220	5	patterns	pattern	NOUN
biomedich-1021	220	6	of	of	ADP
biomedich-1021	220	7	streptococcus	streptococcus	NOUN
biomedich-1021	220	8	pyogenes	pyogene	NOUN
biomedich-1021	220	9	in	in	ADP
biomedich-1021	220	10	türkiye	türkiye	PROPN
biomedich-1021	220	11	.	.	PUNCT
biomedich-1021	221	1	journal	journal	PROPN
biomedich-1021	221	2	of	of	ADP
biomedich-1021	221	3	infection	infection	NOUN
biomedich-1021	221	4	and	and	CCONJ
biomedich-1021	221	5	public	public	ADJ
biomedich-1021	221	6	health	health	NOUN
biomedich-1021	221	7	,	,	PUNCT
biomedich-1021	221	8	18(2	18(2	NUM
biomedich-1021	221	9	)	)	PUNCT
biomedich-1021	221	10	,	,	PUNCT
biomedich-1021	221	11	102633	102633	NUM
biomedich-1021	221	12	.	.	PUNCT
biomedich-1021	222	1	https://doi.org/10.1016/j.jiph.2024.102633	https://doi.org/10.1016/j.jiph.2024.102633	PROPN
biomedich-1021	222	2	van	van	PROPN
biomedich-1021	222	3	de	de	PROPN
biomedich-1021	222	4	waterbeemd	waterbeemd	PROPN
biomedich-1021	222	5	,	,	PUNCT
biomedich-1021	222	6	h.	h.	PROPN
biomedich-1021	222	7	,	,	PUNCT
biomedich-1021	222	8	&	&	CCONJ
biomedich-1021	222	9	gifford	gifford	PROPN
biomedich-1021	222	10	,	,	PUNCT
biomedich-1021	222	11	e.	e.	PROPN
biomedich-1021	222	12	(	(	PUNCT
biomedich-1021	222	13	2003	2003	NUM
biomedich-1021	222	14	)	)	PUNCT
biomedich-1021	222	15	.	.	PUNCT
biomedich-1021	223	1	admet	admet	PROPN
biomedich-1021	223	2	in	in	ADP
biomedich-1021	223	3	silico	silico	NOUN
biomedich-1021	223	4	modelling	modelling	NOUN
biomedich-1021	223	5	:	:	PUNCT
biomedich-1021	223	6	towards	towards	ADP
biomedich-1021	223	7	prediction	prediction	NOUN
biomedich-1021	223	8	paradise	paradise	PROPN
biomedich-1021	223	9	?	?	PUNCT
biomedich-1021	224	1	nature	nature	NOUN
biomedich-1021	224	2	reviews	review	NOUN
biomedich-1021	224	3	.	.	PUNCT
biomedich-1021	225	1	drug	drug	NOUN
biomedich-1021	225	2	discovery	discovery	PROPN
biomedich-1021	225	3	,	,	PUNCT
biomedich-1021	225	4	2(3	2(3	NUM
biomedich-1021	225	5	)	)	PUNCT
biomedich-1021	225	6	,	,	PUNCT
biomedich-1021	225	7	192–204	192–204	NUM
biomedich-1021	225	8	.	.	PUNCT
biomedich-1021	226	1	https://doi.org/10.1038/nrd1032	https://doi.org/10.1038/nrd1032	NUM
biomedich-1021	226	2	waring	waring	NOUN
biomedich-1021	226	3	,	,	PUNCT
biomedich-1021	226	4	m.	m.	NOUN
biomedich-1021	226	5	j.	j.	PROPN
biomedich-1021	226	6	,	,	PUNCT
biomedich-1021	226	7	arrowsmith	arrowsmith	PROPN
biomedich-1021	226	8	,	,	PUNCT
biomedich-1021	226	9	j.	j.	PROPN
biomedich-1021	226	10	,	,	PUNCT
biomedich-1021	226	11	leach	leach	NOUN
biomedich-1021	226	12	,	,	PUNCT
biomedich-1021	226	13	a.	a.	PROPN
biomedich-1021	226	14	r.	r.	PROPN
biomedich-1021	226	15	,	,	PUNCT
biomedich-1021	226	16	leeson	leeson	PROPN
biomedich-1021	226	17	,	,	PUNCT
biomedich-1021	226	18	p.	p.	PROPN
biomedich-1021	226	19	d.	d.	PROPN
biomedich-1021	226	20	,	,	PUNCT
biomedich-1021	226	21	mandrell	mandrell	PROPN
biomedich-1021	226	22	,	,	PUNCT
biomedich-1021	226	23	s.	s.	PROPN
biomedich-1021	226	24	,	,	PUNCT
biomedich-1021	226	25	owen	owen	PROPN
biomedich-1021	226	26	,	,	PUNCT
biomedich-1021	226	27	r.	r.	PROPN
biomedich-1021	226	28	m.	m.	PROPN
biomedich-1021	226	29	,	,	PUNCT
biomedich-1021	226	30	pairaudeau	pairaudeau	PROPN
biomedich-1021	226	31	,	,	PUNCT
biomedich-1021	226	32	g.	g.	PROPN
biomedich-1021	226	33	,	,	PUNCT
biomedich-1021	226	34	pennie	pennie	PROPN
biomedich-1021	226	35	,	,	PUNCT
biomedich-1021	226	36	w.	w.	PROPN
biomedich-1021	226	37	d.	d.	PROPN
biomedich-1021	226	38	,	,	PUNCT
biomedich-1021	226	39	pickett	pickett	PROPN
biomedich-1021	226	40	,	,	PUNCT
biomedich-1021	226	41	s.	s.	PROPN
biomedich-1021	226	42	d.	d.	PROPN
biomedich-1021	226	43	,	,	PUNCT
biomedich-1021	226	44	wang	wang	PROPN
biomedich-1021	226	45	,	,	PUNCT
biomedich-1021	226	46	j.	j.	PROPN
biomedich-1021	226	47	,	,	PUNCT
biomedich-1021	226	48	wallace	wallace	PROPN
biomedich-1021	226	49	,	,	PUNCT
biomedich-1021	226	50	o.	o.	PROPN
biomedich-1021	226	51	,	,	PUNCT
biomedich-1021	226	52	&	&	CCONJ
biomedich-1021	226	53	weir	weir	PROPN
biomedich-1021	226	54	,	,	PUNCT
biomedich-1021	226	55	a.	a.	NOUN
biomedich-1021	226	56	(	(	PUNCT
biomedich-1021	226	57	2015	2015	NUM
biomedich-1021	226	58	)	)	PUNCT
biomedich-1021	226	59	.	.	PUNCT
biomedich-1021	227	1	an	an	DET
biomedich-1021	227	2	analysis	analysis	NOUN
biomedich-1021	227	3	of	of	ADP
biomedich-1021	227	4	the	the	DET
biomedich-1021	227	5	attrition	attrition	NOUN
biomedich-1021	227	6	of	of	ADP
biomedich-1021	227	7	drug	drug	NOUN
biomedich-1021	227	8	candidates	candidate	NOUN
biomedich-1021	227	9	from	from	ADP
biomedich-1021	227	10	four	four	NUM
biomedich-1021	227	11	major	major	ADJ
biomedich-1021	227	12	pharmaceutical	pharmaceutical	ADJ
biomedich-1021	227	13	companies	company	NOUN
biomedich-1021	227	14	.	.	PUNCT
biomedich-1021	228	1	nature	nature	NOUN
biomedich-1021	228	2	reviews	review	NOUN
biomedich-1021	228	3	.	.	PUNCT
biomedich-1021	229	1	drug	drug	NOUN
biomedich-1021	229	2	discovery	discovery	PROPN
biomedich-1021	229	3	,	,	PUNCT
biomedich-1021	229	4	14(7	14(7	NUM
biomedich-1021	229	5	)	)	PUNCT
biomedich-1021	229	6	,	,	PUNCT
biomedich-1021	229	7	475–486	475–486	NUM
biomedich-1021	229	8	.	.	PUNCT
biomedich-1021	230	1	https://doi.org/10.1038/nrd4609	https://doi.org/10.1038/nrd4609	NOUN
biomedich-1021	230	2	this	this	DET
biomedich-1021	230	3	page	page	NOUN
biomedich-1021	230	4	intentionally	intentionally	ADV
biomedich-1021	230	5	left	leave	VERB
biomedich-1021	230	6	blank	blank	ADV