id	sid	tid	token	lemma	pos
biomedich-119	1	1	biology	biology	NOUN
biomedich-119	1	2	,	,	PUNCT
biomedich-119	1	3	medicine	medicine	NOUN
biomedich-119	1	4	,	,	PUNCT
biomedich-119	1	5	&	&	CCONJ
biomedich-119	1	6	natural	natural	ADJ
biomedich-119	1	7	product	product	NOUN
biomedich-119	1	8	chemistry	chemistry	NOUN
biomedich-119	1	9	issn	issn	VERB
biomedich-119	1	10	2089	2089	NUM
biomedich-119	1	11	-	-	SYM
biomedich-119	1	12	6514	6514	NUM
biomedich-119	1	13	(	(	PUNCT
biomedich-119	1	14	paper	paper	NOUN
biomedich-119	1	15	)	)	PUNCT
biomedich-119	1	16	volume	volume	NOUN
biomedich-119	1	17	9	9	NUM
biomedich-119	1	18	,	,	PUNCT
biomedich-119	1	19	number	number	NOUN
biomedich-119	1	20	2	2	NUM
biomedich-119	1	21	,	,	PUNCT
biomedich-119	1	22	october	october	PROPN
biomedich-119	1	23	2020	2020	NUM
biomedich-119	1	24	|	|	ADV
biomedich-119	1	25	pages	page	NOUN
biomedich-119	1	26	:	:	PUNCT
biomedich-119	1	27	57	57	NUM
biomedich-119	1	28	-	-	SYM
biomedich-119	1	29	64	64	NUM
biomedich-119	1	30	|	|	ADV
biomedich-119	1	31	doi	doi	NOUN
biomedich-119	1	32	:	:	PUNCT
biomedich-119	1	33	10.14421	10.14421	NUM
biomedich-119	1	34	/	/	SYM
biomedich-119	1	35	biomedich.2020.92.57	biomedich.2020.92.57	NOUN
biomedich-119	1	36	-	-	PUNCT
biomedich-119	1	37	64	64	NUM
biomedich-119	1	38	issn	issn	PROPN
biomedich-119	1	39	2540	2540	NUM
biomedich-119	1	40	-	-	SYM
biomedich-119	1	41	9328	9328	NUM
biomedich-119	1	42	(	(	PUNCT
biomedich-119	1	43	online	online	ADV
biomedich-119	1	44	)	)	PUNCT
biomedich-119	1	45	the	the	DET
biomedich-119	1	46	role	role	NOUN
biomedich-119	1	47	of	of	ADP
biomedich-119	1	48	gene	gene	NOUN
biomedich-119	1	49	therapy	therapy	NOUN
biomedich-119	1	50	in	in	ADP
biomedich-119	1	51	the	the	DET
biomedich-119	1	52	treatments	treatment	NOUN
biomedich-119	1	53	of	of	ADP
biomedich-119	1	54	type	type	NOUN
biomedich-119	1	55	1	1	NUM
biomedich-119	1	56	diabetes	diabetes	NOUN
biomedich-119	1	57	mellitus	mellitus	NOUN
biomedich-119	1	58	:	:	PUNCT
biomedich-119	1	59	a	a	DET
biomedich-119	1	60	review	review	NOUN
biomedich-119	1	61	harem	harem	VERB
biomedich-119	1	62	othman	othman	PROPN
biomedich-119	1	63	smail	smail	PROPN
biomedich-119	1	64	department	department	PROPN
biomedich-119	1	65	of	of	ADP
biomedich-119	1	66	biology	biology	NOUN
biomedich-119	1	67	,	,	PUNCT
biomedich-119	1	68	faculty	faculty	NOUN
biomedich-119	1	69	of	of	ADP
biomedich-119	1	70	science	science	NOUN
biomedich-119	1	71	and	and	CCONJ
biomedich-119	1	72	health	health	NOUN
biomedich-119	1	73	,	,	PUNCT
biomedich-119	1	74	koya	koya	PROPN
biomedich-119	1	75	university	university	PROPN
biomedich-119	1	76	koya	koya	PROPN
biomedich-119	1	77	koy45	koy45	PROPN
biomedich-119	1	78	,	,	PUNCT
biomedich-119	1	79	kurdistan	kurdistan	PROPN
biomedich-119	1	80	region	region	PROPN
biomedich-119	1	81	f.	f.	PROPN
biomedich-119	1	82	r.	r.	PROPN
biomedich-119	1	83	iraq	iraq	PROPN
biomedich-119	1	84	corresponding	corresponding	PROPN
biomedich-119	1	85	author	author	NOUN
biomedich-119	1	86	harem.othman@koyauniversity.org	harem.othman@koyauniversity.org	PROPN
biomedich-119	1	87	manuscript	manuscript	NOUN
biomedich-119	1	88	received	receive	VERB
biomedich-119	1	89	:	:	PUNCT
biomedich-119	1	90	22	22	NUM
biomedich-119	1	91	july	july	PROPN
biomedich-119	1	92	,	,	PUNCT
biomedich-119	1	93	2020	2020	NUM
biomedich-119	1	94	.	.	PUNCT
biomedich-119	2	1	revision	revision	NOUN
biomedich-119	2	2	accepted	accept	VERB
biomedich-119	2	3	:	:	PUNCT
biomedich-119	2	4	06	06	NUM
biomedich-119	2	5	november	november	PROPN
biomedich-119	2	6	,	,	PUNCT
biomedich-119	2	7	2020	2020	NUM
biomedich-119	2	8	.	.	PUNCT
biomedich-119	3	1	published	publish	VERB
biomedich-119	3	2	:	:	PUNCT
biomedich-119	3	3	10	10	NUM
biomedich-119	3	4	november	november	PROPN
biomedich-119	3	5	,	,	PUNCT
biomedich-119	3	6	2020	2020	NUM
biomedich-119	3	7	.	.	PUNCT
biomedich-119	4	1	abstract	abstract	ADJ
biomedich-119	4	2	the	the	DET
biomedich-119	4	3	main	main	ADJ
biomedich-119	4	4	aims	aim	NOUN
biomedich-119	4	5	of	of	ADP
biomedich-119	4	6	this	this	DET
biomedich-119	4	7	review	review	NOUN
biomedich-119	4	8	were	be	AUX
biomedich-119	4	9	to	to	PART
biomedich-119	4	10	understand	understand	VERB
biomedich-119	4	11	the	the	DET
biomedich-119	4	12	roles	role	NOUN
biomedich-119	4	13	of	of	ADP
biomedich-119	4	14	gene	gene	NOUN
biomedich-119	4	15	therapy	therapy	NOUN
biomedich-119	4	16	in	in	ADP
biomedich-119	4	17	the	the	DET
biomedich-119	4	18	treatment	treatment	NOUN
biomedich-119	4	19	and	and	CCONJ
biomedich-119	4	20	prevention	prevention	NOUN
biomedich-119	4	21	of	of	ADP
biomedich-119	4	22	type	type	NOUN
biomedich-119	4	23	1	1	NUM
biomedich-119	4	24	diabetes	diabetes	NOUN
biomedich-119	4	25	mellitus	mellitus	NOUN
biomedich-119	4	26	and	and	CCONJ
biomedich-119	4	27	i	i	PRON
biomedich-119	4	28	will	will	AUX
biomedich-119	4	29	discuss	discuss	VERB
biomedich-119	4	30	a	a	DET
biomedich-119	4	31	brief	brief	ADJ
biomedich-119	4	32	history	history	NOUN
biomedich-119	4	33	,	,	PUNCT
biomedich-119	4	34	approaches	approach	NOUN
biomedich-119	4	35	,	,	PUNCT
biomedich-119	4	36	vector	vector	NOUN
biomedich-119	4	37	types	type	NOUN
biomedich-119	4	38	with	with	ADP
biomedich-119	4	39	the	the	DET
biomedich-119	4	40	future	future	NOUN
biomedich-119	4	41	of	of	ADP
biomedich-119	4	42	diabetes	diabetes	NOUN
biomedich-119	4	43	following	follow	VERB
biomedich-119	4	44	clinical	clinical	ADJ
biomedich-119	4	45	use	use	NOUN
biomedich-119	4	46	.	.	PUNCT
biomedich-119	5	1	type	type	NOUN
biomedich-119	5	2	1	1	NUM
biomedich-119	5	3	diabetes	diabetes	NOUN
biomedich-119	5	4	mellitus	mellitus	NOUN
biomedich-119	5	5	is	be	AUX
biomedich-119	5	6	a	a	DET
biomedich-119	5	7	metabolic	metabolic	NOUN
biomedich-119	5	8	condition	condition	NOUN
biomedich-119	5	9	that	that	PRON
biomedich-119	5	10	is	be	AUX
biomedich-119	5	11	identified	identify	VERB
biomedich-119	5	12	by	by	ADP
biomedich-119	5	13	insufficient	insufficient	ADJ
biomedich-119	5	14	insulin	insulin	NOUN
biomedich-119	5	15	development	development	NOUN
biomedich-119	5	16	due	due	ADP
biomedich-119	5	17	to	to	ADP
biomedich-119	5	18	pancreatic	pancreatic	ADJ
biomedich-119	5	19	damage	damage	NOUN
biomedich-119	5	20	to	to	ADP
biomedich-119	5	21	beta	beta	ADJ
biomedich-119	5	22	cells	cell	NOUN
biomedich-119	5	23	.	.	PUNCT
biomedich-119	6	1	control	control	NOUN
biomedich-119	6	2	,	,	PUNCT
biomedich-119	6	3	long	long	ADJ
biomedich-119	6	4	life	life	NOUN
biomedich-119	6	5	,	,	PUNCT
biomedich-119	6	6	and	and	CCONJ
biomedich-119	6	7	diagnosis	diagnosis	NOUN
biomedich-119	6	8	of	of	ADP
biomedich-119	6	9	these	these	DET
biomedich-119	6	10	metabolic	metabolic	NOUN
biomedich-119	6	11	disorders	disorder	NOUN
biomedich-119	6	12	have	have	AUX
biomedich-119	6	13	become	become	VERB
biomedich-119	6	14	vital	vital	ADJ
biomedich-119	6	15	sources	source	NOUN
biomedich-119	6	16	for	for	ADP
biomedich-119	6	17	many	many	ADJ
biomedich-119	6	18	scientists	scientist	NOUN
biomedich-119	6	19	and	and	CCONJ
biomedich-119	6	20	researchers	researcher	NOUN
biomedich-119	6	21	.	.	PUNCT
biomedich-119	7	1	after	after	ADP
biomedich-119	7	2	2000	2000	NUM
biomedich-119	7	3	,	,	PUNCT
biomedich-119	7	4	the	the	DET
biomedich-119	7	5	latest	late	ADJ
biomedich-119	7	6	approaches	approach	NOUN
biomedich-119	7	7	to	to	ADP
biomedich-119	7	8	molecular	molecular	ADJ
biomedich-119	7	9	medicine	medicine	NOUN
biomedich-119	7	10	were	be	AUX
biomedich-119	7	11	introduced	introduce	VERB
biomedich-119	7	12	as	as	ADP
biomedich-119	7	13	one	one	NUM
biomedich-119	7	14	of	of	ADP
biomedich-119	7	15	the	the	DET
biomedich-119	7	16	possible	possible	ADJ
biomedich-119	7	17	therapeutic	therapeutic	ADJ
biomedich-119	7	18	options	option	NOUN
biomedich-119	7	19	for	for	ADP
biomedich-119	7	20	diabetes	diabetes	NOUN
biomedich-119	7	21	type	type	NOUN
biomedich-119	7	22	1	1	NUM
biomedich-119	7	23	diagnosis	diagnosis	NOUN
biomedich-119	7	24	.	.	PUNCT
biomedich-119	8	1	many	many	ADJ
biomedich-119	8	2	genes	gene	NOUN
biomedich-119	8	3	have	have	AUX
biomedich-119	8	4	been	be	AUX
biomedich-119	8	5	reported	report	VERB
biomedich-119	8	6	as	as	ADP
biomedich-119	8	7	a	a	DET
biomedich-119	8	8	clinical	clinical	ADJ
biomedich-119	8	9	trial	trial	NOUN
biomedich-119	8	10	so	so	SCONJ
biomedich-119	8	11	that	that	SCONJ
biomedich-119	8	12	damaged	damage	VERB
biomedich-119	8	13	genes	gene	NOUN
biomedich-119	8	14	can	can	AUX
biomedich-119	8	15	be	be	AUX
biomedich-119	8	16	treated	treat	VERB
biomedich-119	8	17	and	and	CCONJ
biomedich-119	8	18	three	three	NUM
biomedich-119	8	19	main	main	ADJ
biomedich-119	8	20	approaches	approach	NOUN
biomedich-119	8	21	shown	show	VERB
biomedich-119	8	22	about	about	ADP
biomedich-119	8	23	50	50	NUM
biomedich-119	8	24	years	year	NOUN
biomedich-119	8	25	ago	ago	ADV
biomedich-119	8	26	are	be	AUX
biomedich-119	8	27	islet	islet	NOUN
biomedich-119	8	28	transplantation	transplantation	NOUN
biomedich-119	8	29	,	,	PUNCT
biomedich-119	8	30	β	β	X
biomedich-119	8	31	cell	cell	NOUN
biomedich-119	8	32	regeneration	regeneration	NOUN
biomedich-119	8	33	,	,	PUNCT
biomedich-119	8	34	and	and	CCONJ
biomedich-119	8	35	insulin	insulin	NOUN
biomedich-119	8	36	gene	gene	NOUN
biomedich-119	8	37	therapy	therapy	NOUN
biomedich-119	8	38	to	to	PART
biomedich-119	8	39	cure	cure	VERB
biomedich-119	8	40	and	and	CCONJ
biomedich-119	8	41	prevent	prevent	VERB
biomedich-119	8	42	diabetes	diabetes	NOUN
biomedich-119	8	43	type	type	NOUN
biomedich-119	8	44	.	.	PUNCT
biomedich-119	9	1	treating	treat	VERB
biomedich-119	9	2	diabetes	diabetes	NOUN
biomedich-119	9	3	through	through	ADP
biomedich-119	9	4	gene	gene	NOUN
biomedich-119	9	5	therapy	therapy	NOUN
biomedich-119	9	6	can	can	AUX
biomedich-119	9	7	promise	promise	VERB
biomedich-119	9	8	children	child	NOUN
biomedich-119	9	9	and	and	CCONJ
biomedich-119	9	10	adolescents	adolescent	NOUN
biomedich-119	9	11	,	,	PUNCT
biomedich-119	9	12	but	but	CCONJ
biomedich-119	9	13	more	more	ADV
biomedich-119	9	14	clinical	clinical	ADJ
biomedich-119	9	15	applications	application	NOUN
biomedich-119	9	16	are	be	AUX
biomedich-119	9	17	needed	need	VERB
biomedich-119	9	18	to	to	PART
biomedich-119	9	19	recognize	recognize	VERB
biomedich-119	9	20	it	it	PRON
biomedich-119	9	21	as	as	ADP
biomedich-119	9	22	a	a	DET
biomedich-119	9	23	permanent	permanent	ADJ
biomedich-119	9	24	route	route	NOUN
biomedich-119	9	25	.	.	PUNCT
biomedich-119	10	1	keywords	keyword	NOUN
biomedich-119	10	2	:	:	PUNCT
biomedich-119	10	3	type	type	NOUN
biomedich-119	10	4	1	1	NUM
biomedich-119	10	5	diabetes	diabetes	NOUN
biomedich-119	10	6	mellitus	mellitus	NOUN
biomedich-119	10	7	;	;	PUNCT
biomedich-119	10	8	gene	gene	NOUN
biomedich-119	10	9	therapy	therapy	NOUN
biomedich-119	10	10	;	;	PUNCT
biomedich-119	10	11	β	β	NOUN
biomedich-119	10	12	cells	cell	NOUN
biomedich-119	10	13	;	;	PUNCT
biomedich-119	10	14	virus	virus	NOUN
biomedich-119	10	15	vectors	vector	NOUN
biomedich-119	10	16	and	and	CCONJ
biomedich-119	10	17	islet	islet	NOUN
biomedich-119	10	18	.	.	PUNCT
biomedich-119	11	1	introduction	introduction	NOUN
biomedich-119	11	2	diabetes	diabetes	NOUN
biomedich-119	11	3	is	be	AUX
biomedich-119	11	4	one	one	NUM
biomedich-119	11	5	of	of	ADP
biomedich-119	11	6	the	the	DET
biomedich-119	11	7	metabolic	metabolic	NOUN
biomedich-119	11	8	disorders	disorder	NOUN
biomedich-119	11	9	characterized	characterize	VERB
biomedich-119	11	10	by	by	ADP
biomedich-119	11	11	hyperglycemia	hyperglycemia	NOUN
biomedich-119	11	12	due	due	ADP
biomedich-119	11	13	to	to	ADP
biomedich-119	11	14	insulin	insulin	NOUN
biomedich-119	11	15	secretion	secretion	NOUN
biomedich-119	11	16	deficits	deficit	NOUN
biomedich-119	11	17	,	,	PUNCT
biomedich-119	11	18	insulin	insulin	NOUN
biomedich-119	11	19	action	action	NOUN
biomedich-119	11	20	,	,	PUNCT
biomedich-119	11	21	or	or	CCONJ
biomedich-119	11	22	both	both	DET
biomedich-119	11	23	(	(	PUNCT
biomedich-119	11	24	smail	smail	NOUN
biomedich-119	11	25	et	et	PROPN
biomedich-119	11	26	al	al	PROPN
biomedich-119	11	27	.	.	PROPN
biomedich-119	11	28	,	,	PUNCT
biomedich-119	11	29	2019	2019	NUM
biomedich-119	11	30	)	)	PUNCT
biomedich-119	11	31	.	.	PUNCT
biomedich-119	12	1	type	type	NOUN
biomedich-119	12	2	1	1	NUM
biomedich-119	12	3	diabetes	diabetes	NOUN
biomedich-119	12	4	mellitus	mellitus	NOUN
biomedich-119	12	5	is	be	AUX
biomedich-119	12	6	caused	cause	VERB
biomedich-119	12	7	by	by	ADP
biomedich-119	12	8	extreme	extreme	ADJ
biomedich-119	12	9	insulin	insulin	NOUN
biomedich-119	12	10	deficiency	deficiency	NOUN
biomedich-119	12	11	secondary	secondary	ADJ
biomedich-119	12	12	to	to	ADP
biomedich-119	12	13	pancreatic	pancreatic	ADJ
biomedich-119	12	14	beta	beta	NOUN
biomedich-119	12	15	cell	cell	NOUN
biomedich-119	12	16	autoimmune	autoimmune	ADJ
biomedich-119	12	17	damage	damage	NOUN
biomedich-119	12	18	(	(	PUNCT
biomedich-119	12	19	kolodka	kolodka	PROPN
biomedich-119	12	20	et	et	PROPN
biomedich-119	12	21	al	al	PROPN
biomedich-119	12	22	.	.	PROPN
biomedich-119	12	23	,	,	PUNCT
biomedich-119	12	24	1995	1995	NUM
biomedich-119	12	25	)	)	PUNCT
biomedich-119	12	26	.	.	PUNCT
biomedich-119	13	1	the	the	DET
biomedich-119	13	2	middle	middle	PROPN
biomedich-119	13	3	east	east	PROPN
biomedich-119	13	4	and	and	CCONJ
biomedich-119	13	5	north	north	PROPN
biomedich-119	13	6	africa	africa	PROPN
biomedich-119	13	7	region	region	PROPN
biomedich-119	13	8	have	have	VERB
biomedich-119	13	9	the	the	DET
biomedich-119	13	10	highest	high	ADJ
biomedich-119	13	11	average	average	ADJ
biomedich-119	13	12	prevalence	prevalence	NOUN
biomedich-119	13	13	of	of	ADP
biomedich-119	13	14	diabetes	diabetes	NOUN
biomedich-119	13	15	in	in	ADP
biomedich-119	13	16	adults	adult	NOUN
biomedich-119	13	17	(	(	PUNCT
biomedich-119	13	18	10.9	10.9	NUM
biomedich-119	13	19	%	%	NOUN
biomedich-119	13	20	)	)	PUNCT
biomedich-119	13	21	,	,	PUNCT
biomedich-119	13	22	while	while	SCONJ
biomedich-119	13	23	the	the	DET
biomedich-119	13	24	western	western	ADJ
biomedich-119	13	25	pacific	pacific	PROPN
biomedich-119	13	26	region	region	NOUN
biomedich-119	13	27	has	have	VERB
biomedich-119	13	28	the	the	DET
biomedich-119	13	29	largest	large	ADJ
biomedich-119	13	30	number	number	NOUN
biomedich-119	13	31	of	of	ADP
biomedich-119	13	32	adults	adult	NOUN
biomedich-119	13	33	diagnosed	diagnose	VERB
biomedich-119	13	34	with	with	ADP
biomedich-119	13	35	diabetes	diabetes	NOUN
biomedich-119	13	36	and	and	CCONJ
biomedich-119	13	37	the	the	DET
biomedich-119	13	38	highest	high	ADJ
biomedich-119	13	39	prevalence	prevalence	NOUN
biomedich-119	13	40	of	of	ADP
biomedich-119	13	41	diabetes	diabetes	NOUN
biomedich-119	13	42	in	in	ADP
biomedich-119	13	43	countries	country	NOUN
biomedich-119	13	44	(	(	PUNCT
biomedich-119	13	45	37.5	37.5	NUM
biomedich-119	13	46	%	%	NOUN
biomedich-119	13	47	)	)	PUNCT
biomedich-119	13	48	.	.	PUNCT
biomedich-119	14	1	in	in	ADP
biomedich-119	14	2	terms	term	NOUN
biomedich-119	14	3	of	of	ADP
biomedich-119	14	4	diagnostic	diagnostic	ADJ
biomedich-119	14	5	criteria	criterion	NOUN
biomedich-119	14	6	,	,	PUNCT
biomedich-119	14	7	etiology	etiology	NOUN
biomedich-119	14	8	,	,	PUNCT
biomedich-119	14	9	and	and	CCONJ
biomedich-119	14	10	genetics	genetic	NOUN
biomedich-119	14	11	,	,	PUNCT
biomedich-119	14	12	various	various	ADJ
biomedich-119	14	13	classes	class	NOUN
biomedich-119	14	14	of	of	ADP
biomedich-119	14	15	diabetes	diabetes	NOUN
biomedich-119	14	16	mellitus	mellitus	NOUN
biomedich-119	14	17	,	,	PUNCT
biomedich-119	14	18	namely	namely	ADV
biomedich-119	14	19	type	type	NOUN
biomedich-119	14	20	1	1	NUM
biomedich-119	14	21	,	,	PUNCT
biomedich-119	14	22	type	type	NOUN
biomedich-119	14	23	2	2	NUM
biomedich-119	14	24	,	,	PUNCT
biomedich-119	14	25	gestational	gestational	ADJ
biomedich-119	14	26	diabetes	diabetes	NOUN
biomedich-119	14	27	,	,	PUNCT
biomedich-119	14	28	and	and	CCONJ
biomedich-119	14	29	other	other	ADJ
biomedich-119	14	30	types	type	NOUN
biomedich-119	14	31	of	of	ADP
biomedich-119	14	32	diabetes	diabetes	NOUN
biomedich-119	14	33	mellitus	mellitus	NOUN
biomedich-119	14	34	are	be	AUX
biomedich-119	14	35	compared	compare	VERB
biomedich-119	14	36	(	(	PUNCT
biomedich-119	14	37	kharroubi	kharroubi	PROPN
biomedich-119	14	38	et	et	PROPN
biomedich-119	14	39	al	al	PROPN
biomedich-119	14	40	.	.	PROPN
biomedich-119	14	41	,	,	PUNCT
biomedich-119	14	42	2015	2015	NUM
biomedich-119	14	43	)	)	PUNCT
biomedich-119	14	44	.	.	PUNCT
biomedich-119	15	1	gene	gene	NOUN
biomedich-119	15	2	therapy	therapy	NOUN
biomedich-119	15	3	is	be	AUX
biomedich-119	15	4	a	a	DET
biomedich-119	15	5	new	new	ADJ
biomedich-119	15	6	form	form	NOUN
biomedich-119	15	7	of	of	ADP
biomedich-119	15	8	molecular	molecular	ADJ
biomedich-119	15	9	medicine	medicine	NOUN
biomedich-119	15	10	that	that	PRON
biomedich-119	15	11	will	will	AUX
biomedich-119	15	12	have	have	VERB
biomedich-119	15	13	a	a	DET
biomedich-119	15	14	significant	significant	ADJ
biomedich-119	15	15	impact	impact	NOUN
biomedich-119	15	16	on	on	ADP
biomedich-119	15	17	human	human	ADJ
biomedich-119	15	18	health	health	NOUN
biomedich-119	15	19	in	in	ADP
biomedich-119	15	20	the	the	DET
biomedich-119	15	21	next	next	ADJ
biomedich-119	15	22	century	century	NOUN
biomedich-119	15	23	(	(	PUNCT
biomedich-119	15	24	verma	verma	PROPN
biomedich-119	15	25	et	et	PROPN
biomedich-119	15	26	al	al	PROPN
biomedich-119	15	27	.	.	PROPN
biomedich-119	15	28	,	,	PUNCT
biomedich-119	15	29	2000	2000	NUM
biomedich-119	15	30	)	)	PUNCT
biomedich-119	15	31	.	.	PUNCT
biomedich-119	16	1	visionary	visionary	ADJ
biomedich-119	16	2	scientists	scientist	NOUN
biomedich-119	16	3	had	have	AUX
biomedich-119	16	4	hypothesized	hypothesize	VERB
biomedich-119	16	5	almost	almost	ADV
biomedich-119	16	6	five	five	NUM
biomedich-119	16	7	decades	decade	NOUN
biomedich-119	16	8	ago	ago	ADV
biomedich-119	16	9	that	that	SCONJ
biomedich-119	16	10	genetic	genetic	ADJ
biomedich-119	16	11	modification	modification	NOUN
biomedich-119	16	12	by	by	ADP
biomedich-119	16	13	exogenous	exogenous	ADJ
biomedich-119	16	14	dna	dna	NOUN
biomedich-119	16	15	could	could	AUX
biomedich-119	16	16	be	be	AUX
biomedich-119	16	17	an	an	DET
biomedich-119	16	18	effective	effective	ADJ
biomedich-119	16	19	treatment	treatment	NOUN
biomedich-119	16	20	for	for	ADP
biomedich-119	16	21	inherited	inherit	VERB
biomedich-119	16	22	human	human	ADJ
biomedich-119	16	23	diseases	disease	NOUN
biomedich-119	16	24	.	.	PUNCT
biomedich-119	17	1	this	this	DET
biomedich-119	17	2	strategy	strategy	NOUN
biomedich-119	17	3	of	of	ADP
biomedich-119	17	4	“	"	PUNCT
biomedich-119	17	5	gene	gene	NOUN
biomedich-119	17	6	therapy	therapy	NOUN
biomedich-119	17	7	”	"	PUNCT
biomedich-119	17	8	offered	offer	VERB
biomedich-119	17	9	the	the	DET
biomedich-119	17	10	theoretical	theoretical	ADJ
biomedich-119	17	11	advantage	advantage	NOUN
biomedich-119	17	12	that	that	PRON
biomedich-119	17	13	one	one	NUM
biomedich-119	17	14	single	single	ADJ
biomedich-119	17	15	treatment	treatment	NOUN
biomedich-119	17	16	would	would	AUX
biomedich-119	17	17	achieve	achieve	VERB
biomedich-119	17	18	a	a	DET
biomedich-119	17	19	lasting	lasting	ADJ
biomedich-119	17	20	and	and	CCONJ
biomedich-119	17	21	possibly	possibly	ADV
biomedich-119	17	22	curative	curative	VERB
biomedich-119	17	23	clinical	clinical	ADJ
biomedich-119	17	24	benefit	benefit	NOUN
biomedich-119	17	25	(	(	PUNCT
biomedich-119	17	26	dunbar	dunbar	NOUN
biomedich-119	17	27	et	et	PROPN
biomedich-119	17	28	al	al	PROPN
biomedich-119	17	29	.	.	PROPN
biomedich-119	17	30	,	,	PUNCT
biomedich-119	17	31	2018	2018	NUM
biomedich-119	17	32	)	)	PUNCT
biomedich-119	17	33	.	.	PUNCT
biomedich-119	18	1	recent	recent	ADJ
biomedich-119	18	2	gene	gene	NOUN
biomedich-119	18	3	therapy	therapy	NOUN
biomedich-119	18	4	clinical	clinical	ADJ
biomedich-119	18	5	trials	trial	NOUN
biomedich-119	18	6	have	have	AUX
biomedich-119	18	7	shown	show	VERB
biomedich-119	18	8	considerable	considerable	ADJ
biomedich-119	18	9	therapeutic	therapeutic	ADJ
biomedich-119	18	10	benefits	benefit	NOUN
biomedich-119	18	11	and	and	CCONJ
biomedich-119	18	12	an	an	DET
biomedich-119	18	13	excellent	excellent	ADJ
biomedich-119	18	14	safety	safety	NOUN
biomedich-119	18	15	record	record	NOUN
biomedich-119	18	16	.	.	PUNCT
biomedich-119	19	1	they	they	PRON
biomedich-119	19	2	show	show	VERB
biomedich-119	19	3	the	the	DET
biomedich-119	19	4	long	long	ADV
biomedich-119	19	5	-	-	PUNCT
biomedich-119	19	6	sought	seek	VERB
biomedich-119	19	7	-	-	PUNCT
biomedich-119	19	8	after	after	NOUN
biomedich-119	19	9	potential	potential	NOUN
biomedich-119	19	10	of	of	ADP
biomedich-119	19	11	gene	gene	NOUN
biomedich-119	19	12	therapy	therapy	NOUN
biomedich-119	19	13	to	to	PART
biomedich-119	19	14	provide	provide	VERB
biomedich-119	19	15	'	'	PUNCT
biomedich-119	19	16	cures	cure	NOUN
biomedich-119	19	17	'	'	PUNCT
biomedich-119	19	18	after	after	ADP
biomedich-119	19	19	certain	certain	ADJ
biomedich-119	19	20	potentially	potentially	ADV
biomedich-119	19	21	terminal	terminal	ADJ
biomedich-119	19	22	or	or	CCONJ
biomedich-119	19	23	seriously	seriously	ADV
biomedich-119	19	24	disabled	disabled	ADJ
biomedich-119	19	25	disorders	disorder	NOUN
biomedich-119	19	26	(	(	PUNCT
biomedich-119	19	27	naldini	naldini	NOUN
biomedich-119	19	28	,	,	PUNCT
biomedich-119	19	29	2015	2015	NUM
biomedich-119	19	30	)	)	PUNCT
biomedich-119	19	31	.	.	PUNCT
biomedich-119	20	1	to	to	ADP
biomedich-119	20	2	date	date	NOUN
biomedich-119	20	3	,	,	PUNCT
biomedich-119	20	4	approximately	approximately	ADV
biomedich-119	20	5	2600	2600	NUM
biomedich-119	20	6	clinical	clinical	ADJ
biomedich-119	20	7	trials	trial	NOUN
biomedich-119	20	8	on	on	ADP
biomedich-119	20	9	gene	gene	NOUN
biomedich-119	20	10	therapy	therapy	NOUN
biomedich-119	20	11	have	have	AUX
biomedich-119	20	12	been	be	AUX
biomedich-119	20	13	completed	complete	VERB
biomedich-119	20	14	,	,	PUNCT
biomedich-119	20	15	are	be	AUX
biomedich-119	20	16	underway	underway	ADJ
biomedich-119	20	17	,	,	PUNCT
biomedich-119	20	18	or	or	CCONJ
biomedich-119	20	19	licensed	license	VERB
biomedich-119	20	20	worldwide	worldwide	ADV
biomedich-119	20	21	(	(	PUNCT
biomedich-119	20	22	ginn	ginn	PROPN
biomedich-119	20	23	et	et	PROPN
biomedich-119	20	24	al	al	PROPN
biomedich-119	20	25	.	.	PROPN
biomedich-119	20	26	,	,	PUNCT
biomedich-119	20	27	2018	2018	NUM
biomedich-119	20	28	)	)	PUNCT
biomedich-119	20	29	.	.	PUNCT
biomedich-119	21	1	gene	gene	NOUN
biomedich-119	21	2	therapy	therapy	NOUN
biomedich-119	21	3	is	be	AUX
biomedich-119	21	4	intended	intend	VERB
biomedich-119	21	5	to	to	PART
biomedich-119	21	6	inject	inject	VERB
biomedich-119	21	7	genetic	genetic	ADJ
biomedich-119	21	8	material	material	NOUN
biomedich-119	21	9	into	into	ADP
biomedich-119	21	10	patient	patient	ADJ
biomedich-119	21	11	cells	cell	NOUN
biomedich-119	21	12	to	to	PART
biomedich-119	21	13	compensate	compensate	VERB
biomedich-119	21	14	for	for	ADP
biomedich-119	21	15	damaged	damage	VERB
biomedich-119	21	16	genes	gene	NOUN
biomedich-119	21	17	or	or	CCONJ
biomedich-119	21	18	to	to	PART
biomedich-119	21	19	include	include	VERB
biomedich-119	21	20	therapeutic	therapeutic	ADJ
biomedich-119	21	21	transgenes	transgene	NOUN
biomedich-119	21	22	.	.	PUNCT
biomedich-119	22	1	gene	gene	NOUN
biomedich-119	22	2	therapy	therapy	NOUN
biomedich-119	22	3	has	have	AUX
biomedich-119	22	4	advanced	advance	VERB
biomedich-119	22	5	from	from	ADP
biomedich-119	22	6	the	the	DET
biomedich-119	22	7	initial	initial	ADJ
biomedich-119	22	8	human	human	ADJ
biomedich-119	22	9	gene	gene	NOUN
biomedich-119	22	10	transfer	transfer	NOUN
biomedich-119	22	11	trials	trial	NOUN
biomedich-119	22	12	to	to	ADP
biomedich-119	22	13	approved	approve	VERB
biomedich-119	22	14	clinical	clinical	ADJ
biomedich-119	22	15	therapies	therapy	NOUN
biomedich-119	22	16	over	over	ADP
biomedich-119	22	17	the	the	DET
biomedich-119	22	18	past	past	ADJ
biomedich-119	22	19	three	three	NUM
biomedich-119	22	20	decades	decade	NOUN
biomedich-119	22	21	(	(	PUNCT
biomedich-119	22	22	wang	wang	PROPN
biomedich-119	22	23	et	et	PROPN
biomedich-119	22	24	al	al	PROPN
biomedich-119	22	25	.	.	PROPN
biomedich-119	22	26	,	,	PUNCT
biomedich-119	22	27	2020	2020	NUM
biomedich-119	22	28	)	)	PUNCT
biomedich-119	22	29	.	.	PUNCT
biomedich-119	23	1	modern	modern	ADJ
biomedich-119	23	2	therapeutic	therapeutic	ADJ
biomedich-119	23	3	strategies	strategy	NOUN
biomedich-119	23	4	seek	seek	VERB
biomedich-119	23	5	to	to	PART
biomedich-119	23	6	restore	restore	VERB
biomedich-119	23	7	the	the	DET
biomedich-119	23	8	endogenous	endogenous	ADJ
biomedich-119	23	9	insulin	insulin	NOUN
biomedich-119	23	10	production	production	NOUN
biomedich-119	23	11	rather	rather	ADV
biomedich-119	23	12	than	than	ADP
biomedich-119	23	13	traditional	traditional	ADJ
biomedich-119	23	14	insulin	insulin	NOUN
biomedich-119	23	15	injection	injection	NOUN
biomedich-119	23	16	treatment	treatment	NOUN
biomedich-119	23	17	(	(	PUNCT
biomedich-119	23	18	memon	memon	NOUN
biomedich-119	23	19	and	and	CCONJ
biomedich-119	23	20	abdelalim	abdelalim	PROPN
biomedich-119	23	21	2020	2020	NUM
biomedich-119	23	22	)	)	PUNCT
biomedich-119	23	23	.	.	PUNCT
biomedich-119	24	1	differentiation	differentiation	NOUN
biomedich-119	24	2	of	of	ADP
biomedich-119	24	3	insulin	insulin	NOUN
biomedich-119	24	4	-	-	PUNCT
biomedich-119	24	5	producing	produce	VERB
biomedich-119	24	6	pancreatic	pancreatic	ADJ
biomedich-119	24	7	β	β	NOUN
biomedich-119	24	8	cells	cell	NOUN
biomedich-119	24	9	from	from	ADP
biomedich-119	24	10	induced	induce	VERB
biomedich-119	24	11	pluripotent	pluripotent	ADJ
biomedich-119	24	12	stem	stem	NOUN
biomedich-119	24	13	cells	cell	NOUN
biomedich-119	24	14	(	(	PUNCT
biomedich-119	24	15	ipscs	ipscs	NOUN
biomedich-119	24	16	)	)	PUNCT
biomedich-119	24	17	originating	originate	VERB
biomedich-119	24	18	from	from	ADP
biomedich-119	24	19	diabetes	diabetes	NOUN
biomedich-119	24	20	patients	patient	NOUN
biomedich-119	24	21	aims	aim	VERB
biomedich-119	24	22	to	to	PART
biomedich-119	24	23	provide	provide	VERB
biomedich-119	24	24	autologous	autologous	ADJ
biomedich-119	24	25	cells	cell	NOUN
biomedich-119	24	26	for	for	ADP
biomedich-119	24	27	cell	cell	NOUN
biomedich-119	24	28	replacement	replacement	NOUN
biomedich-119	24	29	therapy	therapy	NOUN
biomedich-119	24	30	for	for	ADP
biomedich-119	24	31	diabetes	diabetes	NOUN
biomedich-119	24	32	.	.	PUNCT
biomedich-119	25	1	present	present	ADJ
biomedich-119	25	2	methods	method	NOUN
biomedich-119	25	3	,	,	PUNCT
biomedich-119	25	4	however	however	ADV
biomedich-119	25	5	,	,	PUNCT
biomedich-119	25	6	generate	generate	VERB
biomedich-119	25	7	patient	patient	ADJ
biomedich-119	25	8	ipsc	ipsc	NOUN
biomedich-119	25	9	-	-	PUNCT
biomedich-119	25	10	derived	derive	VERB
biomedich-119	25	11	β	β	X
biomedich-119	25	12	(	(	PUNCT
biomedich-119	25	13	sc	sc	PROPN
biomedich-119	25	14	-	-	PUNCT
biomedich-119	25	15	β	β	NOUN
biomedich-119	25	16	)	)	PUNCT
biomedich-119	25	17	cells	cell	NOUN
biomedich-119	25	18	with	with	ADP
biomedich-119	25	19	low	low	ADJ
biomedich-119	25	20	in	in	ADP
biomedich-119	25	21	vitro	vitro	X
biomedich-119	25	22	and	and	CCONJ
biomedich-119	25	23	in	in	ADP
biomedich-119	25	24	vivo	vivo	ADJ
biomedich-119	25	25	function	function	NOUN
biomedich-119	25	26	(	(	PUNCT
biomedich-119	25	27	maxwell	maxwell	PROPN
biomedich-119	25	28	et	et	PROPN
biomedich-119	25	29	al	al	PROPN
biomedich-119	25	30	.	.	PROPN
biomedich-119	25	31	,	,	PUNCT
biomedich-119	25	32	2020	2020	NUM
biomedich-119	25	33	)	)	PUNCT
biomedich-119	25	34	.	.	PUNCT
biomedich-119	26	1	in	in	ADP
biomedich-119	26	2	several	several	ADJ
biomedich-119	26	3	ways	way	NOUN
biomedich-119	26	4	,	,	PUNCT
biomedich-119	26	5	cell	cell	NOUN
biomedich-119	26	6	replacement	replacement	NOUN
biomedich-119	26	7	therapy	therapy	NOUN
biomedich-119	26	8	for	for	ADP
biomedich-119	26	9	type	type	NOUN
biomedich-119	26	10	1	1	NUM
biomedich-119	26	11	diabetes	diabetes	NOUN
biomedich-119	26	12	(	(	PUNCT
biomedich-119	26	13	t1d	t1d	NOUN
biomedich-119	26	14	)	)	PUNCT
biomedich-119	26	15	is	be	AUX
biomedich-119	26	16	a	a	DET
biomedich-119	26	17	perfect	perfect	ADJ
biomedich-119	26	18	first	first	ADJ
biomedich-119	26	19	drug	drug	NOUN
biomedich-119	26	20	model	model	NOUN
biomedich-119	26	21	to	to	PART
biomedich-119	26	22	follow	follow	VERB
biomedich-119	26	23	in	in	ADP
biomedich-119	26	24	the	the	DET
biomedich-119	26	25	emerging	emerge	VERB
biomedich-119	26	26	field	field	NOUN
biomedich-119	26	27	of	of	ADP
biomedich-119	26	28	regenerative	regenerative	ADJ
biomedich-119	26	29	medicine	medicine	NOUN
biomedich-119	26	30	(	(	PUNCT
biomedich-119	26	31	brandon	brandon	PROPN
biomedich-119	26	32	et	et	PROPN
biomedich-119	26	33	al	al	PROPN
biomedich-119	26	34	.	.	PROPN
biomedich-119	26	35	,	,	PUNCT
biomedich-119	26	36	2020	2020	NUM
biomedich-119	26	37	)	)	PUNCT
biomedich-119	26	38	.	.	PUNCT
biomedich-119	27	1	history	history	NOUN
biomedich-119	27	2	of	of	ADP
biomedich-119	27	3	gene	gene	NOUN
biomedich-119	27	4	therapy	therapy	NOUN
biomedich-119	27	5	the	the	DET
biomedich-119	27	6	ideas	idea	NOUN
biomedich-119	27	7	of	of	ADP
biomedich-119	27	8	gene	gene	NOUN
biomedich-119	27	9	therapy	therapy	NOUN
biomedich-119	27	10	emerged	emerge	VERB
biomedich-119	27	11	in	in	ADP
biomedich-119	27	12	the	the	DET
biomedich-119	27	13	1960s	1960	NOUN
biomedich-119	27	14	and	and	CCONJ
biomedich-119	27	15	early	early	ADJ
biomedich-119	27	16	1970s	1970	NOUN
biomedich-119	27	17	,	,	PUNCT
biomedich-119	27	18	while	while	SCONJ
biomedich-119	27	19	in	in	ADP
biomedich-119	27	20	1968	1968	NUM
biomedich-119	27	21	rogers	roger	NOUN
biomedich-119	27	22	&	&	CCONJ
biomedich-119	27	23	pfuderer	pfuderer	PROPN
biomedich-119	27	24	demonstrated	demonstrate	VERB
biomedich-119	27	25	a	a	DET
biomedich-119	27	26	proof	proof	NOUN
biomedich-119	27	27	of	of	ADP
biomedich-119	27	28	concept	concept	NOUN
biomedich-119	27	29	for	for	ADP
biomedich-119	27	30	virus	virus	NOUN
biomedich-119	27	31	-	-	PUNCT
biomedich-119	27	32	mediated	mediate	VERB
biomedich-119	27	33	gene	gene	NOUN
biomedich-119	27	34	transfer	transfer	NOUN
biomedich-119	27	35	(	(	PUNCT
biomedich-119	27	36	wirth	wirth	PROPN
biomedich-119	27	37	et	et	PROPN
biomedich-119	27	38	al	al	PROPN
biomedich-119	27	39	.	.	PROPN
biomedich-119	27	40	,	,	PUNCT
biomedich-119	27	41	2013	2013	NUM
biomedich-119	27	42	)	)	PUNCT
biomedich-119	27	43	,	,	PUNCT
biomedich-119	27	44	development	development	NOUN
biomedich-119	27	45	of	of	ADP
biomedich-119	27	46	genetically	genetically	ADV
biomedich-119	27	47	https://doi.org/10.14421/biomedich.2020.92.57-64	https://doi.org/10.14421/biomedich.2020.92.57-64	ADJ
biomedich-119	27	48	58	58	NUM
biomedich-119	27	49	biology	biology	NOUN
biomedich-119	27	50	,	,	PUNCT
biomedich-119	27	51	medicine	medicine	NOUN
biomedich-119	27	52	,	,	PUNCT
biomedich-119	27	53	&	&	CCONJ
biomedich-119	27	54	natural	natural	ADJ
biomedich-119	27	55	product	product	NOUN
biomedich-119	27	56	chemistry	chemistry	NOUN
biomedich-119	27	57	9	9	NUM
biomedich-119	27	58	(	(	PUNCT
biomedich-119	27	59	2	2	NUM
biomedich-119	27	60	)	)	PUNCT
biomedich-119	27	61	,	,	PUNCT
biomedich-119	27	62	2020	2020	NUM
biomedich-119	27	63	:	:	PUNCT
biomedich-119	27	64	57	57	NUM
biomedich-119	27	65	-	-	SYM
biomedich-119	27	66	64	64	NUM
biomedich-119	27	67	marked	mark	VERB
biomedich-119	27	68	cell	cell	NOUN
biomedich-119	27	69	lines	line	NOUN
biomedich-119	27	70	and	and	CCONJ
biomedich-119	27	71	explanation	explanation	NOUN
biomedich-119	27	72	of	of	ADP
biomedich-119	27	73	the	the	DET
biomedich-119	27	74	polyoma	polyoma	NOUN
biomedich-119	27	75	and	and	CCONJ
biomedich-119	27	76	sv40	sv40	PROPN
biomedich-119	27	77	papovavirus	papovavirus	NOUN
biomedich-119	27	78	mechanisms	mechanism	NOUN
biomedich-119	27	79	of	of	ADP
biomedich-119	27	80	cell	cell	NOUN
biomedich-119	27	81	transformation	transformation	NOUN
biomedich-119	27	82	(	(	PUNCT
biomedich-119	27	83	friedmann	friedmann	NOUN
biomedich-119	27	84	,	,	PUNCT
biomedich-119	27	85	1992	1992	NUM
biomedich-119	27	86	)	)	PUNCT
biomedich-119	27	87	.	.	PUNCT
biomedich-119	28	1	modern	modern	ADJ
biomedich-119	28	2	transfection	transfection	NOUN
biomedich-119	28	3	methods	method	NOUN
biomedich-119	28	4	were	be	AUX
biomedich-119	28	5	combined	combine	VERB
biomedich-119	28	6	with	with	ADP
biomedich-119	28	7	cultured	cultured	ADJ
biomedich-119	28	8	cell	cell	NOUN
biomedich-119	28	9	selection	selection	NOUN
biomedich-119	28	10	systems	system	NOUN
biomedich-119	28	11	and	and	CCONJ
biomedich-119	28	12	recombinant	recombinant	ADJ
biomedich-119	28	13	dna	dna	NOUN
biomedich-119	28	14	technology	technology	NOUN
biomedich-119	28	15	in	in	ADP
biomedich-119	28	16	the	the	DET
biomedich-119	28	17	late	late	ADJ
biomedich-119	28	18	1970s.the	1970s.the	DET
biomedich-119	28	19	possibility	possibility	NOUN
biomedich-119	28	20	of	of	ADP
biomedich-119	28	21	successful	successful	ADJ
biomedich-119	28	22	gene	gene	NOUN
biomedich-119	28	23	transfer	transfer	NOUN
biomedich-119	28	24	into	into	ADP
biomedich-119	28	25	mammalian	mammalian	ADJ
biomedich-119	28	26	cells	cell	NOUN
biomedich-119	28	27	for	for	ADP
biomedich-119	28	28	gene	gene	NOUN
biomedich-119	28	29	therapy	therapy	NOUN
biomedich-119	28	30	purposes	purpose	NOUN
biomedich-119	28	31	was	be	AUX
biomedich-119	28	32	generally	generally	ADV
biomedich-119	28	33	recognized	recognize	VERB
biomedich-119	28	34	with	with	ADP
biomedich-119	28	35	the	the	DET
biomedich-119	28	36	creation	creation	NOUN
biomedich-119	28	37	of	of	ADP
biomedich-119	28	38	retroviral	retroviral	ADJ
biomedich-119	28	39	vectors	vector	NOUN
biomedich-119	28	40	in	in	ADP
biomedich-119	28	41	the	the	DET
biomedich-119	28	42	early	early	ADJ
biomedich-119	28	43	1980s	1980	NOUN
biomedich-119	28	44	(	(	PUNCT
biomedich-119	28	45	wolff	wolff	NOUN
biomedich-119	28	46	et	et	PROPN
biomedich-119	28	47	al	al	PROPN
biomedich-119	28	48	.	.	PROPN
biomedich-119	28	49	,	,	PUNCT
biomedich-119	28	50	1994	1994	NUM
biomedich-119	28	51	)	)	PUNCT
biomedich-119	28	52	.	.	PUNCT
biomedich-119	29	1	however	however	ADV
biomedich-119	29	2	,	,	PUNCT
biomedich-119	29	3	clinical	clinical	ADJ
biomedich-119	29	4	efficacy	efficacy	NOUN
biomedich-119	29	5	in	in	ADP
biomedich-119	29	6	a	a	DET
biomedich-119	29	7	small	small	ADJ
biomedich-119	29	8	-	-	PUNCT
biomedich-119	29	9	scale	scale	NOUN
biomedich-119	29	10	clinical	clinical	ADJ
biomedich-119	29	11	trial	trial	NOUN
biomedich-119	29	12	curing	cure	VERB
biomedich-119	29	13	an	an	DET
biomedich-119	29	14	otherwise	otherwise	ADV
biomedich-119	29	15	fatal	fatal	ADJ
biomedich-119	29	16	immunodeficiency	immunodeficiency	NOUN
biomedich-119	29	17	disorder	disorder	NOUN
biomedich-119	29	18	in	in	ADP
biomedich-119	29	19	children	child	NOUN
biomedich-119	29	20	could	could	AUX
biomedich-119	29	21	not	not	PART
biomedich-119	29	22	be	be	AUX
biomedich-119	29	23	demonstrated	demonstrate	VERB
biomedich-119	29	24	until	until	ADP
biomedich-119	29	25	the	the	DET
biomedich-119	29	26	start	start	NOUN
biomedich-119	29	27	of	of	ADP
biomedich-119	29	28	the	the	DET
biomedich-119	29	29	new	new	ADJ
biomedich-119	29	30	century	century	NOUN
biomedich-119	29	31	(	(	PUNCT
biomedich-119	29	32	escors	escor	NOUN
biomedich-119	29	33	et	et	PROPN
biomedich-119	29	34	al	al	PROPN
biomedich-119	29	35	.	.	PROPN
biomedich-119	29	36	,	,	PUNCT
biomedich-119	29	37	2010	2010	NUM
biomedich-119	29	38	)	)	PUNCT
biomedich-119	29	39	.	.	PUNCT
biomedich-119	30	1	pancreatic	pancreatic	ADJ
biomedich-119	30	2	transplantation	transplantation	NOUN
biomedich-119	30	3	,	,	PUNCT
biomedich-119	30	4	first	first	ADV
biomedich-119	30	5	performed	perform	VERB
biomedich-119	30	6	in	in	ADP
biomedich-119	30	7	1966	1966	NUM
biomedich-119	30	8	,	,	PUNCT
biomedich-119	30	9	exists	exist	VERB
biomedich-119	30	10	in	in	ADP
biomedich-119	30	11	the	the	DET
biomedich-119	30	12	new	new	ADJ
biomedich-119	30	13	millennium	millennium	NOUN
biomedich-119	30	14	as	as	ADP
biomedich-119	30	15	a	a	DET
biomedich-119	30	16	radical	radical	ADJ
biomedich-119	30	17	treatment	treatment	NOUN
biomedich-119	30	18	for	for	ADP
biomedich-119	30	19	particularly	particularly	ADV
biomedich-119	30	20	intractable	intractable	ADJ
biomedich-119	30	21	type	type	NOUN
biomedich-119	30	22	i	i	PRON
biomedich-119	30	23	diabetes	diabete	VERB
biomedich-119	30	24	with	with	ADP
biomedich-119	30	25	advanced	advanced	ADJ
biomedich-119	30	26	complications	complication	NOUN
biomedich-119	30	27	.	.	PUNCT
biomedich-119	31	1	gene	gene	NOUN
biomedich-119	31	2	therapy	therapy	NOUN
biomedich-119	31	3	with	with	ADP
biomedich-119	31	4	molecules	molecule	NOUN
biomedich-119	31	5	like	like	ADP
biomedich-119	31	6	leptin	leptin	NOUN
biomedich-119	31	7	and	and	CCONJ
biomedich-119	31	8	insulin	insulin	NOUN
biomedich-119	31	9	,	,	PUNCT
biomedich-119	31	10	still	still	ADV
biomedich-119	31	11	in	in	ADP
biomedich-119	31	12	experimental	experimental	ADJ
biomedich-119	31	13	mode	mode	NOUN
biomedich-119	31	14	,	,	PUNCT
biomedich-119	31	15	may	may	AUX
biomedich-119	31	16	one	one	NUM
biomedich-119	31	17	day	day	NOUN
biomedich-119	31	18	become	become	VERB
biomedich-119	31	19	a	a	DET
biomedich-119	31	20	reality	reality	NOUN
biomedich-119	31	21	(	(	PUNCT
biomedich-119	31	22	lakhtakia	lakhtakia	NOUN
biomedich-119	31	23	,	,	PUNCT
biomedich-119	31	24	2013	2013	NUM
biomedich-119	31	25	)	)	PUNCT
biomedich-119	31	26	.	.	PUNCT
biomedich-119	32	1	clinically	clinically	ADV
biomedich-119	32	2	active	active	ADJ
biomedich-119	32	3	islet	islet	NOUN
biomedich-119	32	4	-	-	PUNCT
biomedich-119	32	5	free	free	ADJ
biomedich-119	32	6	implants	implant	NOUN
biomedich-119	32	7	began	begin	VERB
biomedich-119	32	8	in	in	ADP
biomedich-119	32	9	1989	1989	NUM
biomedich-119	32	10	which	which	PRON
biomedich-119	32	11	require	require	VERB
biomedich-119	32	12	immunosuppression	immunosuppression	NOUN
biomedich-119	32	13	for	for	ADP
biomedich-119	32	14	long	long	ADJ
biomedich-119	32	15	life	life	NOUN
biomedich-119	32	16	.	.	PUNCT
biomedich-119	33	1	for	for	ADP
biomedich-119	33	2	more	more	ADJ
biomedich-119	33	3	than	than	ADP
biomedich-119	33	4	30	30	NUM
biomedich-119	33	5	years	year	NOUN
biomedich-119	33	6	,	,	PUNCT
biomedich-119	33	7	several	several	ADJ
biomedich-119	33	8	encapsulated	encapsulate	VERB
biomedich-119	33	9	islet	islet	NOUN
biomedich-119	33	10	approaches	approach	NOUN
biomedich-119	33	11	have	have	AUX
biomedich-119	33	12	been	be	AUX
biomedich-119	33	13	ongoing	ongoing	ADJ
biomedich-119	33	14	without	without	ADP
biomedich-119	33	15	the	the	DET
biomedich-119	33	16	definition	definition	NOUN
biomedich-119	33	17	of	of	ADP
biomedich-119	33	18	a	a	DET
biomedich-119	33	19	clinically	clinically	ADV
biomedich-119	33	20	relevant	relevant	ADJ
biomedich-119	33	21	product	product	NOUN
biomedich-119	33	22	(	(	PUNCT
biomedich-119	33	23	scharp	scharp	PROPN
biomedich-119	33	24	et	et	PROPN
biomedich-119	33	25	al	al	PROPN
biomedich-119	33	26	.	.	PROPN
biomedich-119	33	27	,	,	PUNCT
biomedich-119	33	28	2014	2014	NUM
biomedich-119	33	29	)	)	PUNCT
biomedich-119	33	30	.	.	PUNCT
biomedich-119	34	1	approaches	approach	NOUN
biomedich-119	34	2	for	for	ADP
biomedich-119	34	3	gene	gene	NOUN
biomedich-119	34	4	therapy	therapy	NOUN
biomedich-119	34	5	in	in	ADP
biomedich-119	34	6	type	type	NOUN
biomedich-119	34	7	1	1	NUM
biomedich-119	34	8	of	of	ADP
biomedich-119	34	9	diabetes	diabetes	NOUN
biomedich-119	34	10	a	a	DET
biomedich-119	34	11	cure	cure	NOUN
biomedich-119	34	12	for	for	ADP
biomedich-119	34	13	type	type	NOUN
biomedich-119	34	14	1	1	NUM
biomedich-119	34	15	(	(	PUNCT
biomedich-119	34	16	insulin	insulin	NOUN
biomedich-119	34	17	-	-	PUNCT
biomedich-119	34	18	dependent	dependent	ADJ
biomedich-119	34	19	)	)	PUNCT
biomedich-119	34	20	diabetes	diabetes	NOUN
biomedich-119	34	21	could	could	AUX
biomedich-119	34	22	be	be	AUX
biomedich-119	34	23	found	find	VERB
biomedich-119	34	24	to	to	PART
biomedich-119	34	25	replace	replace	VERB
biomedich-119	34	26	β	β	NOUN
biomedich-119	34	27	cells	cell	NOUN
biomedich-119	34	28	in	in	ADP
biomedich-119	34	29	the	the	DET
biomedich-119	34	30	generation	generation	NOUN
biomedich-119	34	31	of	of	ADP
biomedich-119	34	32	surrogate	surrogate	ADJ
biomedich-119	34	33	insulin	insulin	NOUN
biomedich-119	34	34	-	-	PUNCT
biomedich-119	34	35	producing	produce	VERB
biomedich-119	34	36	cells	cell	NOUN
biomedich-119	34	37	(	(	PUNCT
biomedich-119	34	38	samson	samson	NOUN
biomedich-119	34	39	and	and	CCONJ
biomedich-119	34	40	chan	chan	PROPN
biomedich-119	34	41	,	,	PUNCT
biomedich-119	34	42	2006	2006	NUM
biomedich-119	34	43	)	)	PUNCT
biomedich-119	34	44	.	.	PUNCT
biomedich-119	35	1	several	several	ADJ
biomedich-119	35	2	different	different	ADJ
biomedich-119	35	3	approaches	approach	NOUN
biomedich-119	35	4	have	have	AUX
biomedich-119	35	5	long	long	ADV
biomedich-119	35	6	been	be	AUX
biomedich-119	35	7	used	use	VERB
biomedich-119	35	8	to	to	PART
biomedich-119	35	9	seek	seek	VERB
biomedich-119	35	10	a	a	DET
biomedich-119	35	11	cure	cure	NOUN
biomedich-119	35	12	for	for	ADP
biomedich-119	35	13	diabetes	diabetes	NOUN
biomedich-119	35	14	,	,	PUNCT
biomedich-119	35	15	including	include	VERB
biomedich-119	35	16	islet	islet	NOUN
biomedich-119	35	17	transplantation	transplantation	NOUN
biomedich-119	35	18	,	,	PUNCT
biomedich-119	35	19	β	β	X
biomedich-119	35	20	cell	cell	NOUN
biomedich-119	35	21	regeneration	regeneration	NOUN
biomedich-119	35	22	,	,	PUNCT
biomedich-119	35	23	and	and	CCONJ
biomedich-119	35	24	insulin	insulin	NOUN
biomedich-119	35	25	gene	gene	NOUN
biomedich-119	35	26	therapy	therapy	NOUN
biomedich-119	35	27	(	(	PUNCT
biomedich-119	35	28	lee	lee	PROPN
biomedich-119	35	29	et	et	PROPN
biomedich-119	35	30	al	al	PROPN
biomedich-119	35	31	.	.	PROPN
biomedich-119	35	32	,	,	PUNCT
biomedich-119	35	33	2000	2000	NUM
biomedich-119	35	34	)	)	PUNCT
biomedich-119	35	35	.	.	PUNCT
biomedich-119	36	1	islet	islet	NOUN
biomedich-119	36	2	transplantation	transplantation	VERB
biomedich-119	36	3	the	the	DET
biomedich-119	36	4	idea	idea	NOUN
biomedich-119	36	5	of	of	ADP
biomedich-119	36	6	t1d	t1d	PROPN
biomedich-119	36	7	cell	cell	NOUN
biomedich-119	36	8	replacement	replacement	NOUN
biomedich-119	36	9	therapy	therapy	NOUN
biomedich-119	36	10	remained	remain	VERB
biomedich-119	36	11	dormant	dormant	ADJ
biomedich-119	36	12	for	for	ADP
biomedich-119	36	13	80	80	NUM
biomedich-119	36	14	years	year	NOUN
biomedich-119	36	15	until	until	ADP
biomedich-119	36	16	1972	1972	NUM
biomedich-119	36	17	when	when	SCONJ
biomedich-119	36	18	ballinger	ballinger	PROPN
biomedich-119	36	19	and	and	CCONJ
biomedich-119	36	20	lacy	lacy	NOUN
biomedich-119	36	21	reversed	reverse	VERB
biomedich-119	36	22	chemical	chemical	ADJ
biomedich-119	36	23	diabetes	diabetes	NOUN
biomedich-119	36	24	by	by	ADP
biomedich-119	36	25	islet	islet	NOUN
biomedich-119	36	26	transplantation	transplantation	NOUN
biomedich-119	36	27	in	in	ADP
biomedich-119	36	28	rats	rat	NOUN
biomedich-119	36	29	(	(	PUNCT
biomedich-119	36	30	shapiro	shapiro	NOUN
biomedich-119	36	31	,	,	PUNCT
biomedich-119	36	32	2012	2012	NUM
biomedich-119	36	33	)	)	PUNCT
biomedich-119	36	34	.	.	PUNCT
biomedich-119	37	1	following	follow	VERB
biomedich-119	37	2	the	the	DET
biomedich-119	37	3	success	success	NOUN
biomedich-119	37	4	of	of	ADP
biomedich-119	37	5	steroidfree	steroidfree	NOUN
biomedich-119	37	6	immunosuppression	immunosuppression	NOUN
biomedich-119	37	7	transplantation	transplantation	NOUN
biomedich-119	37	8	of	of	ADP
biomedich-119	37	9	fresh	fresh	ADJ
biomedich-119	37	10	human	human	ADJ
biomedich-119	37	11	islets	islet	NOUN
biomedich-119	37	12	(	(	PUNCT
biomedich-119	37	13	froud	froud	PROPN
biomedich-119	37	14	et	et	PROPN
biomedich-119	37	15	al	al	PROPN
biomedich-119	37	16	.	.	PROPN
biomedich-119	37	17	,	,	PUNCT
biomedich-119	37	18	2005	2005	NUM
biomedich-119	37	19	)	)	PUNCT
biomedich-119	37	20	.	.	PUNCT
biomedich-119	38	1	the	the	DET
biomedich-119	38	2	inexorable	inexorable	ADJ
biomedich-119	38	3	decline	decline	NOUN
biomedich-119	38	4	in	in	ADP
biomedich-119	38	5	insulin	insulin	NOUN
biomedich-119	38	6	independence	independence	NOUN
biomedich-119	38	7	following	follow	VERB
biomedich-119	38	8	islet	islet	NOUN
biomedich-119	38	9	transplantation	transplantation	NOUN
biomedich-119	38	10	alone	alone	ADV
biomedich-119	38	11	(	(	PUNCT
biomedich-119	38	12	ita	ita	NOUN
biomedich-119	38	13	)	)	PUNCT
biomedich-119	38	14	has	have	AUX
biomedich-119	38	15	raised	raise	VERB
biomedich-119	38	16	concerns	concern	NOUN
biomedich-119	38	17	regarding	regard	VERB
biomedich-119	38	18	its	its	PRON
biomedich-119	38	19	clinical	clinical	ADJ
biomedich-119	38	20	utility	utility	NOUN
biomedich-119	38	21	(	(	PUNCT
biomedich-119	38	22	bellin	bellin	PROPN
biomedich-119	38	23	et	et	PROPN
biomedich-119	38	24	al	al	PROPN
biomedich-119	38	25	.	.	PROPN
biomedich-119	38	26	,	,	PUNCT
biomedich-119	38	27	2012	2012	NUM
biomedich-119	38	28	)	)	PUNCT
biomedich-119	38	29	.	.	PUNCT
biomedich-119	39	1	allotransplantation	allotransplantation	NOUN
biomedich-119	39	2	of	of	ADP
biomedich-119	39	3	islets	islet	NOUN
biomedich-119	39	4	into	into	ADP
biomedich-119	39	5	patients	patient	NOUN
biomedich-119	39	6	with	with	ADP
biomedich-119	39	7	autoimmune	autoimmune	ADJ
biomedich-119	39	8	type	type	NOUN
biomedich-119	39	9	1	1	NUM
biomedich-119	39	10	diabetes	diabetes	NOUN
biomedich-119	39	11	is	be	AUX
biomedich-119	39	12	a	a	DET
biomedich-119	39	13	reexposure	reexposure	NOUN
biomedich-119	39	14	to	to	ADP
biomedich-119	39	15	autoantigen	autoantigen	PROPN
biomedich-119	39	16	(	(	PUNCT
biomedich-119	39	17	bosi	bosi	NOUN
biomedich-119	39	18	et	et	NOUN
biomedich-119	39	19	al	al	PROPN
biomedich-119	39	20	.	.	PROPN
biomedich-119	39	21	,	,	PUNCT
biomedich-119	39	22	2001	2001	NUM
biomedich-119	39	23	)	)	PUNCT
biomedich-119	39	24	.	.	PUNCT
biomedich-119	40	1	although	although	SCONJ
biomedich-119	40	2	immunosuppression	immunosuppression	NOUN
biomedich-119	40	3	protocols	protocol	NOUN
biomedich-119	40	4	have	have	AUX
biomedich-119	40	5	improved	improve	VERB
biomedich-119	40	6	islet	islet	NOUN
biomedich-119	40	7	transplant	transplant	NOUN
biomedich-119	40	8	outcomes	outcome	NOUN
biomedich-119	40	9	,	,	PUNCT
biomedich-119	40	10	more	more	ADJ
biomedich-119	40	11	research	research	NOUN
biomedich-119	40	12	is	be	AUX
biomedich-119	40	13	required	require	VERB
biomedich-119	40	14	to	to	PART
biomedich-119	40	15	maximize	maximize	VERB
biomedich-119	40	16	islet	islet	NOUN
biomedich-119	40	17	availability	availability	NOUN
biomedich-119	40	18	for	for	ADP
biomedich-119	40	19	transplantation	transplantation	NOUN
biomedich-119	40	20	and	and	CCONJ
biomedich-119	40	21	improve	improve	VERB
biomedich-119	40	22	the	the	DET
biomedich-119	40	23	viability	viability	NOUN
biomedich-119	40	24	of	of	ADP
biomedich-119	40	25	islets	islet	NOUN
biomedich-119	40	26	once	once	ADV
biomedich-119	40	27	transplanted	transplant	VERB
biomedich-119	40	28	(	(	PUNCT
biomedich-119	40	29	zarinsefat	zarinsefat	NOUN
biomedich-119	40	30	and	and	CCONJ
biomedich-119	40	31	stock	stock	NOUN
biomedich-119	40	32	,	,	PUNCT
biomedich-119	40	33	2020	2020	NUM
biomedich-119	40	34	)	)	PUNCT
biomedich-119	40	35	.	.	PUNCT
biomedich-119	41	1	islet	islet	NOUN
biomedich-119	41	2	transplantation	transplantation	NOUN
biomedich-119	41	3	in	in	ADP
biomedich-119	41	4	patients	patient	NOUN
biomedich-119	41	5	with	with	ADP
biomedich-119	41	6	type	type	NOUN
biomedich-119	41	7	1	1	NUM
biomedich-119	41	8	diabetes	diabetes	NOUN
biomedich-119	41	9	can	can	AUX
biomedich-119	41	10	reduce	reduce	VERB
biomedich-119	41	11	or	or	CCONJ
biomedich-119	41	12	eliminate	eliminate	VERB
biomedich-119	41	13	the	the	DET
biomedich-119	41	14	insulin	insulin	NOUN
biomedich-119	41	15	requirement	requirement	NOUN
biomedich-119	41	16	.	.	PUNCT
biomedich-119	42	1	exenatide	exenatide	PROPN
biomedich-119	42	2	is	be	AUX
biomedich-119	42	3	a	a	DET
biomedich-119	42	4	long	long	ADV
biomedich-119	42	5	-	-	PUNCT
biomedich-119	42	6	acting	act	VERB
biomedich-119	42	7	glucagon	glucagon	NOUN
biomedich-119	42	8	-	-	PUNCT
biomedich-119	42	9	like	like	ADJ
biomedich-119	42	10	peptide-1	peptide-1	PROPN
biomedich-119	42	11	(	(	PUNCT
biomedich-119	42	12	glp-1	glp-1	NOUN
biomedich-119	42	13	)	)	PUNCT
biomedich-119	42	14	analog	analog	NOUN
biomedich-119	42	15	that	that	PRON
biomedich-119	42	16	increases	increase	VERB
biomedich-119	42	17	glucose	glucose	NOUN
biomedich-119	42	18	-	-	PUNCT
biomedich-119	42	19	induced	induce	VERB
biomedich-119	42	20	insulin	insulin	NOUN
biomedich-119	42	21	secretion	secretion	NOUN
biomedich-119	42	22	and	and	CCONJ
biomedich-119	42	23	may	may	AUX
biomedich-119	42	24	increase	increase	VERB
biomedich-119	42	25	the	the	DET
biomedich-119	42	26	mass	mass	NOUN
biomedich-119	42	27	of	of	ADP
biomedich-119	42	28	β	β	PROPN
biomedich-119	42	29	cells	cell	NOUN
biomedich-119	42	30	(	(	PUNCT
biomedich-119	42	31	al	al	PROPN
biomedich-119	42	32	et	et	PROPN
biomedich-119	42	33	al	al	PROPN
biomedich-119	42	34	.	.	PROPN
biomedich-119	42	35	,	,	PUNCT
biomedich-119	42	36	2007	2007	NUM
biomedich-119	42	37	)	)	PUNCT
biomedich-119	42	38	.	.	PUNCT
biomedich-119	43	1	glucagon	glucagon	NOUN
biomedich-119	43	2	responses	response	NOUN
biomedich-119	43	3	of	of	ADP
biomedich-119	43	4	islet	islet	NOUN
biomedich-119	43	5	transplant	transplant	NOUN
biomedich-119	43	6	recipients	recipient	NOUN
biomedich-119	43	7	to	to	ADP
biomedich-119	43	8	hypoglycemia	hypoglycemia	NOUN
biomedich-119	43	9	were	be	AUX
biomedich-119	43	10	significantly	significantly	ADV
biomedich-119	43	11	lower	low	ADJ
biomedich-119	43	12	than	than	ADP
biomedich-119	43	13	those	those	PRON
biomedich-119	43	14	observed	observe	VERB
biomedich-119	43	15	in	in	ADP
biomedich-119	43	16	control	control	NOUN
biomedich-119	43	17	subjects	subject	NOUN
biomedich-119	43	18	(	(	PUNCT
biomedich-119	43	19	incremental	incremental	ADJ
biomedich-119	43	20	glucagon	glucagon	NOUN
biomedich-119	44	1	[	[	X
biomedich-119	44	2	mean	mean	X
biomedich-119	44	3	±	±	NUM
biomedich-119	44	4	se	se	X
biomedich-119	44	5	]	]	X
biomedich-119	44	6	:	:	PUNCT
biomedich-119	44	7	−12	−12	X
biomedich-119	44	8	±	±	NOUN
biomedich-119	44	9	12	12	NUM
biomedich-119	44	10	vs.	vs.	ADP
biomedich-119	44	11	64	64	NUM
biomedich-119	44	12	±	±	NUM
biomedich-119	44	13	22	22	NUM
biomedich-119	44	14	pg	pg	NOUN
biomedich-119	44	15	/	/	SYM
biomedich-119	44	16	ml	ml	NOUN
biomedich-119	44	17	,	,	PUNCT
biomedich-119	44	18	respectively	respectively	ADV
biomedich-119	44	19	;	;	PUNCT
biomedich-119	44	20	p	p	X
biomedich-119	44	21	<	<	X
biomedich-119	44	22	0,05	0,05	NOUN
biomedich-119	44	23	)	)	PUNCT
biomedich-119	44	24	,	,	PUNCT
biomedich-119	44	25	and	and	CCONJ
biomedich-119	44	26	not	not	PART
biomedich-119	44	27	significantly	significantly	ADV
biomedich-119	44	28	different	different	ADJ
biomedich-119	44	29	from	from	ADP
biomedich-119	44	30	those	those	PRON
biomedich-119	44	31	of	of	ADP
biomedich-119	44	32	non	non	ADJ
biomedich-119	44	33	-	-	ADJ
biomedich-119	44	34	transplant	transplant	ADJ
biomedich-119	44	35	type	type	NOUN
biomedich-119	44	36	1	1	NUM
biomedich-119	44	37	diabetic	diabetic	ADJ
biomedich-119	44	38	subjects	subject	NOUN
biomedich-119	44	39	(	(	PUNCT
biomedich-119	44	40	−17	−17	X
biomedich-119	44	41	±	±	NUM
biomedich-119	44	42	10	10	NUM
biomedich-119	44	43	pg	pg	NOUN
biomedich-119	44	44	/	/	SYM
biomedich-119	44	45	ml	ml	NOUN
biomedich-119	44	46	)	)	PUNCT
biomedich-119	44	47	(	(	PUNCT
biomedich-119	44	48	paty	paty	NOUN
biomedich-119	44	49	et	et	PROPN
biomedich-119	44	50	al	al	PROPN
biomedich-119	44	51	.	.	PROPN
biomedich-119	44	52	,	,	PUNCT
biomedich-119	44	53	2002	2002	NUM
biomedich-119	44	54	)	)	PUNCT
biomedich-119	44	55	.	.	PUNCT
biomedich-119	45	1	a	a	DET
biomedich-119	45	2	glucose	glucose	NOUN
biomedich-119	45	3	-	-	PUNCT
biomedich-119	45	4	potentiated	potentiate	VERB
biomedich-119	45	5	arginine	arginine	NOUN
biomedich-119	45	6	test	test	NOUN
biomedich-119	45	7	,	,	PUNCT
biomedich-119	45	8	conducted	conduct	VERB
biomedich-119	45	9	only	only	ADV
biomedich-119	45	10	in	in	ADP
biomedich-119	45	11	insulin	insulin	NOUN
biomedich-119	45	12	-	-	PUNCT
biomedich-119	45	13	independent	independent	ADJ
biomedich-119	45	14	transplant	transplant	NOUN
biomedich-119	45	15	subjects	subject	NOUN
biomedich-119	45	16	(	(	PUNCT
biomedich-119	45	17	n	n	NOUN
biomedich-119	45	18	=	=	SYM
biomedich-119	45	19	5	5	NUM
biomedich-119	45	20	)	)	PUNCT
biomedich-119	45	21	,	,	PUNCT
biomedich-119	45	22	showed	show	VERB
biomedich-119	45	23	significant	significant	ADJ
biomedich-119	45	24	impairments	impairment	NOUN
biomedich-119	45	25	in	in	ADP
biomedich-119	45	26	the	the	DET
biomedich-119	45	27	glucose	glucose	NOUN
biomedich-119	45	28	-	-	PUNCT
biomedich-119	45	29	potential	potential	NOUN
biomedich-119	45	30	slope	slope	NOUN
biomedich-119	45	31	(	(	PUNCT
biomedich-119	45	32	p	p	X
biomedich-119	45	33	<	<	X
biomedich-119	45	34	0.05	0.05	NUM
biomedich-119	45	35	)	)	PUNCT
biomedich-119	45	36	and	and	CCONJ
biomedich-119	45	37	the	the	DET
biomedich-119	45	38	maximum	maximum	ADJ
biomedich-119	45	39	response	response	NOUN
biomedich-119	45	40	to	to	ADP
biomedich-119	45	41	arginine	arginine	NOUN
biomedich-119	45	42	(	(	PUNCT
biomedich-119	45	43	armax	armax	VERB
biomedich-119	45	44	;	;	PUNCT
biomedich-119	45	45	p	p	X
biomedich-119	45	46	<	<	X
biomedich-119	45	47	0.05	0.05	NUM
biomedich-119	45	48	)	)	PUNCT
biomedich-119	45	49	,	,	PUNCT
biomedich-119	45	50	a	a	DET
biomedich-119	45	51	measure	measure	NOUN
biomedich-119	45	52	of	of	ADP
biomedich-119	45	53	βcell	βcell	NOUN
biomedich-119	45	54	secretory	secretory	NOUN
biomedich-119	45	55	capacity	capacity	NOUN
biomedich-119	45	56	.	.	PUNCT
biomedich-119	46	1	because	because	SCONJ
biomedich-119	46	2	armax	armax	NOUN
biomedich-119	46	3	provides	provide	VERB
biomedich-119	46	4	an	an	DET
biomedich-119	46	5	estimate	estimate	NOUN
biomedich-119	46	6	of	of	ADP
biomedich-119	46	7	the	the	DET
biomedich-119	46	8	functional	functional	ADJ
biomedich-119	46	9	β	β	NOUN
biomedich-119	46	10	-	-	NOUN
biomedich-119	46	11	cell	cell	NOUN
biomedich-119	46	12	mass	mass	NOUN
biomedich-119	46	13	,	,	PUNCT
biomedich-119	46	14	these	these	DET
biomedich-119	46	15	results	result	NOUN
biomedich-119	46	16	suggest	suggest	VERB
biomedich-119	46	17	that	that	SCONJ
biomedich-119	46	18	the	the	DET
biomedich-119	46	19	functional	functional	ADJ
biomedich-119	46	20	defects	defect	NOUN
biomedich-119	46	21	observed	observe	VERB
biomedich-119	46	22	after	after	SCONJ
biomedich-119	46	23	islet	islet	NOUN
biomedich-119	46	24	transplantation	transplantation	NOUN
biomedich-119	46	25	may	may	AUX
biomedich-119	46	26	account	account	VERB
biomedich-119	46	27	for	for	ADP
biomedich-119	46	28	a	a	DET
biomedich-119	46	29	low	low	ADJ
biomedich-119	46	30	engrafted	engraft	VERB
biomedich-119	46	31	β	β	NOUN
biomedich-119	46	32	-	-	NOUN
biomedich-119	46	33	cell	cell	NOUN
biomedich-119	46	34	mass	mass	NOUN
biomedich-119	46	35	(	(	PUNCT
biomedich-119	46	36	rickels	rickel	NOUN
biomedich-119	46	37	et	et	NOUN
biomedich-119	46	38	al	al	PROPN
biomedich-119	46	39	.	.	PROPN
biomedich-119	46	40	,	,	PUNCT
biomedich-119	46	41	2005	2005	NUM
biomedich-119	46	42	)	)	PUNCT
biomedich-119	46	43	.	.	PUNCT
biomedich-119	47	1	moreover	moreover	ADV
biomedich-119	47	2	,	,	PUNCT
biomedich-119	47	3	approximately	approximately	ADV
biomedich-119	47	4	70	70	NUM
biomedich-119	47	5	percent	percent	NOUN
biomedich-119	47	6	of	of	ADP
biomedich-119	47	7	transplanted	transplanted	ADJ
biomedich-119	47	8	type	type	NOUN
biomedich-119	47	9	1	1	NUM
biomedich-119	47	10	diabetic	diabetic	ADJ
biomedich-119	47	11	patients	patient	NOUN
biomedich-119	47	12	achieved	achieve	VERB
biomedich-119	47	13	insulin	insulin	NOUN
biomedich-119	47	14	independence	independence	NOUN
biomedich-119	47	15	(	(	PUNCT
biomedich-119	47	16	matsumoto	matsumoto	NOUN
biomedich-119	47	17	,	,	PUNCT
biomedich-119	47	18	2010	2010	NUM
biomedich-119	47	19	)	)	PUNCT
biomedich-119	47	20	.	.	PUNCT
biomedich-119	48	1	by	by	ADP
biomedich-119	48	2	contrast	contrast	NOUN
biomedich-119	48	3	,	,	PUNCT
biomedich-119	48	4	a	a	DET
biomedich-119	48	5	clinical	clinical	ADJ
biomedich-119	48	6	review	review	NOUN
biomedich-119	48	7	at	at	ADP
biomedich-119	48	8	the	the	DET
biomedich-119	48	9	bmj	bmj	NOUN
biomedich-119	48	10	in	in	ADP
biomedich-119	48	11	2001	2001	NUM
biomedich-119	48	12	anticipated	anticipate	VERB
biomedich-119	48	13	that	that	DET
biomedich-119	48	14	transplantation	transplantation	NOUN
biomedich-119	48	15	of	of	ADP
biomedich-119	48	16	langerhans	langerhans	ADJ
biomedich-119	48	17	islets	islet	NOUN
biomedich-119	48	18	would	would	AUX
biomedich-119	48	19	be	be	AUX
biomedich-119	48	20	the	the	DET
biomedich-119	48	21	treatment	treatment	NOUN
biomedich-119	48	22	of	of	ADP
biomedich-119	48	23	choice	choice	NOUN
biomedich-119	48	24	for	for	ADP
biomedich-119	48	25	most	most	ADJ
biomedich-119	48	26	type	type	NOUN
biomedich-119	48	27	1	1	NUM
biomedich-119	48	28	patients	patient	NOUN
biomedich-119	48	29	diabetes	diabetes	NOUN
biomedich-119	48	30	by	by	ADP
biomedich-119	48	31	2010	2010	NUM
biomedich-119	48	32	.	.	PUNCT
biomedich-119	49	1	islet	islet	NOUN
biomedich-119	49	2	transplantation	transplantation	NOUN
biomedich-119	49	3	is	be	AUX
biomedich-119	49	4	currently	currently	ADV
biomedich-119	49	5	an	an	DET
biomedich-119	49	6	option	option	NOUN
biomedich-119	49	7	for	for	ADP
biomedich-119	49	8	a	a	DET
biomedich-119	49	9	specific	specific	ADJ
biomedich-119	49	10	group	group	NOUN
biomedich-119	49	11	of	of	ADP
biomedich-119	49	12	patients	patient	NOUN
biomedich-119	49	13	with	with	ADP
biomedich-119	49	14	type	type	NOUN
biomedich-119	49	15	1	1	NUM
biomedich-119	49	16	diabetes	diabetes	NOUN
biomedich-119	49	17	only	only	ADV
biomedich-119	49	18	—	—	PUNCT
biomedich-119	49	19	those	those	PRON
biomedich-119	49	20	with	with	ADP
biomedich-119	49	21	severe	severe	ADJ
biomedich-119	49	22	glycaemic	glycaemic	ADJ
biomedich-119	49	23	lability	lability	NOUN
biomedich-119	49	24	,	,	PUNCT
biomedich-119	49	25	recurrent	recurrent	ADJ
biomedich-119	49	26	hypoglycemia	hypoglycemia	NOUN
biomedich-119	49	27	,	,	PUNCT
biomedich-119	49	28	and	and	CCONJ
biomedich-119	49	29	unawareness	unawareness	NOUN
biomedich-119	49	30	of	of	ADP
biomedich-119	49	31	hypoglycemia	hypoglycemia	NOUN
biomedich-119	49	32	(	(	PUNCT
biomedich-119	49	33	de	de	X
biomedich-119	49	34	et	et	PROPN
biomedich-119	49	35	al	al	PROPN
biomedich-119	49	36	.	.	PROPN
biomedich-119	49	37	,	,	PUNCT
biomedich-119	49	38	2011	2011	NUM
biomedich-119	49	39	)	)	PUNCT
biomedich-119	49	40	.	.	PUNCT
biomedich-119	50	1	iak	iak	PROPN
biomedich-119	50	2	was	be	AUX
biomedich-119	50	3	associated	associate	VERB
biomedich-119	50	4	with	with	ADP
biomedich-119	50	5	better	well	ADJ
biomedich-119	50	6	glucose	glucose	NOUN
biomedich-119	50	7	control	control	NOUN
biomedich-119	50	8	and	and	CCONJ
biomedich-119	50	9	a	a	DET
biomedich-119	50	10	slower	slow	ADJ
biomedich-119	50	11	decrease	decrease	NOUN
biomedich-119	50	12	in	in	ADP
biomedich-119	50	13	egfr	egfr	NOUN
biomedich-119	50	14	than	than	ADP
biomedich-119	50	15	standard	standard	ADJ
biomedich-119	50	16	insulin	insulin	NOUN
biomedich-119	50	17	therapy	therapy	NOUN
biomedich-119	50	18	in	in	ADP
biomedich-119	50	19	patients	patient	NOUN
biomedich-119	50	20	with	with	ADP
biomedich-119	50	21	type	type	NOUN
biomedich-119	50	22	1	1	NUM
biomedich-119	50	23	diabetes	diabetes	NOUN
biomedich-119	50	24	and	and	CCONJ
biomedich-119	50	25	a	a	DET
biomedich-119	50	26	functioning	function	VERB
biomedich-119	50	27	kidney	kidney	NOUN
biomedich-119	50	28	transplant	transplant	NOUN
biomedich-119	50	29	(	(	PUNCT
biomedich-119	50	30	maanaoui	maanaoui	PROPN
biomedich-119	50	31	et	et	PROPN
biomedich-119	50	32	al	al	PROPN
biomedich-119	50	33	.	.	PROPN
biomedich-119	50	34	,	,	PUNCT
biomedich-119	50	35	2020	2020	NUM
biomedich-119	50	36	)	)	PUNCT
biomedich-119	50	37	.	.	PUNCT
biomedich-119	51	1	in	in	ADP
biomedich-119	51	2	this	this	DET
biomedich-119	51	3	first	first	ADJ
biomedich-119	51	4	doubleblind	doubleblind	NOUN
biomedich-119	51	5	randomized	randomize	VERB
biomedich-119	51	6	trial	trial	NOUN
biomedich-119	51	7	,	,	PUNCT
biomedich-119	51	8	the	the	DET
biomedich-119	51	9	islet	islet	NOUN
biomedich-119	51	10	transplant	transplant	NOUN
biomedich-119	51	11	evidence	evidence	NOUN
biomedich-119	51	12	obtained	obtain	VERB
biomedich-119	51	13	with	with	ADP
biomedich-119	51	14	reparixin	reparixin	NOUN
biomedich-119	51	15	does	do	AUX
biomedich-119	51	16	not	not	PART
biomedich-119	51	17	support	support	VERB
biomedich-119	51	18	the	the	DET
biomedich-119	51	19	role	role	NOUN
biomedich-119	51	20	of	of	ADP
biomedich-119	51	21	cxcr1/2	cxcr1/2	ADJ
biomedich-119	51	22	inhibition	inhibition	NOUN
biomedich-119	51	23	in	in	ADP
biomedich-119	51	24	preventing	prevent	VERB
biomedich-119	51	25	inflammationmediated	inflammationmediated	ADJ
biomedich-119	51	26	damage	damage	NOUN
biomedich-119	51	27	to	to	ADP
biomedich-119	51	28	the	the	DET
biomedich-119	51	29	islet	islet	NOUN
biomedich-119	51	30	(	(	PUNCT
biomedich-119	51	31	maffi	maffi	ADV
biomedich-119	51	32	et	et	PROPN
biomedich-119	51	33	al	al	PROPN
biomedich-119	51	34	.	.	PROPN
biomedich-119	51	35	,	,	PUNCT
biomedich-119	51	36	2020	2020	NUM
biomedich-119	51	37	)	)	PUNCT
biomedich-119	51	38	.	.	PUNCT
biomedich-119	52	1	regeneration	regeneration	NOUN
biomedich-119	52	2	of	of	ADP
biomedich-119	52	3	β	β	PROPN
biomedich-119	52	4	cells	cell	NOUN
biomedich-119	52	5	one	one	NUM
biomedich-119	52	6	goal	goal	NOUN
biomedich-119	52	7	of	of	ADP
biomedich-119	52	8	regenerative	regenerative	ADJ
biomedich-119	52	9	medicine	medicine	NOUN
biomedich-119	52	10	is	be	AUX
biomedich-119	52	11	the	the	DET
biomedich-119	52	12	instructive	instructive	ADJ
biomedich-119	52	13	incorporation	incorporation	NOUN
biomedich-119	52	14	of	of	ADP
biomedich-119	52	15	adult	adult	NOUN
biomedich-119	52	16	cells	cell	NOUN
biomedich-119	52	17	into	into	ADP
biomedich-119	52	18	other	other	ADJ
biomedich-119	52	19	forms	form	NOUN
biomedich-119	52	20	of	of	ADP
biomedich-119	52	21	cells	cell	NOUN
biomedich-119	52	22	for	for	ADP
biomedich-119	52	23	tissue	tissue	NOUN
biomedich-119	52	24	repair	repair	NOUN
biomedich-119	52	25	and	and	CCONJ
biomedich-119	52	26	regeneration	regeneration	NOUN
biomedich-119	52	27	(	(	PUNCT
biomedich-119	52	28	zhou	zhou	X
biomedich-119	52	29	et	et	PROPN
biomedich-119	52	30	al	al	PROPN
biomedich-119	52	31	.	.	PROPN
biomedich-119	52	32	,	,	PUNCT
biomedich-119	52	33	2008	2008	NUM
biomedich-119	52	34	)	)	PUNCT
biomedich-119	52	35	.	.	PUNCT
biomedich-119	53	1	two	two	NUM
biomedich-119	53	2	major	major	ADJ
biomedich-119	53	3	efforts	effort	NOUN
biomedich-119	53	4	are	be	AUX
biomedich-119	53	5	underway	underway	ADJ
biomedich-119	53	6	to	to	PART
biomedich-119	53	7	address	address	VERB
biomedich-119	53	8	the	the	DET
biomedich-119	53	9	β	β	NOUN
biomedich-119	53	10	-	-	NOUN
biomedich-119	53	11	cell	cell	NOUN
biomedich-119	53	12	diabetes	diabetes	NOUN
biomedich-119	53	13	deficit	deficit	NOUN
biomedich-119	53	14	:	:	PUNCT
biomedich-119	53	15	one	one	PRON
biomedich-119	53	16	would	would	AUX
biomedich-119	53	17	produce	produce	VERB
biomedich-119	53	18	ex	ex	PRON
biomedich-119	53	19	vivo	vivo	ADJ
biomedich-119	53	20	β	β	NOUN
biomedich-119	53	21	-	-	NOUN
biomedich-119	53	22	cells	cell	NOUN
biomedich-119	53	23	that	that	PRON
biomedich-119	53	24	are	be	AUX
biomedich-119	53	25	appropriate	appropriate	ADJ
biomedich-119	53	26	for	for	ADP
biomedich-119	53	27	transplantation	transplantation	NOUN
biomedich-119	53	28	,	,	PUNCT
biomedich-119	53	29	and	and	CCONJ
biomedich-119	53	30	the	the	DET
biomedich-119	53	31	other	other	ADJ
biomedich-119	53	32	would	would	AUX
biomedich-119	53	33	promote	promote	VERB
biomedich-119	53	34	β	β	NOUN
biomedich-119	53	35	-	-	NOUN
biomedich-119	53	36	cell	cell	NOUN
biomedich-119	53	37	regeneration	regeneration	NOUN
biomedich-119	53	38	in	in	ADP
biomedich-119	53	39	the	the	DET
biomedich-119	53	40	pancreas	pancreas	NOUN
biomedich-119	53	41	(	(	PUNCT
biomedich-119	53	42	bonner	bonner	PROPN
biomedich-119	53	43	et	et	PROPN
biomedich-119	53	44	al	al	PROPN
biomedich-119	53	45	.	.	PROPN
biomedich-119	53	46	,	,	PUNCT
biomedich-119	53	47	2005	2005	NUM
biomedich-119	53	48	)	)	PUNCT
biomedich-119	53	49	.	.	PUNCT
biomedich-119	54	1	the	the	DET
biomedich-119	54	2	regeneration	regeneration	NOUN
biomedich-119	54	3	of	of	ADP
biomedich-119	54	4	pancreatic	pancreatic	ADJ
biomedich-119	54	5	β	β	NOUN
biomedich-119	54	6	cells	cell	NOUN
biomedich-119	54	7	which	which	PRON
biomedich-119	54	8	produce	produce	VERB
biomedich-119	54	9	insulin	insulin	NOUN
biomedich-119	54	10	is	be	AUX
biomedich-119	54	11	a	a	DET
biomedich-119	54	12	key	key	ADJ
biomedich-119	54	13	therapeutic	therapeutic	ADJ
biomedich-119	54	14	strategy	strategy	NOUN
biomedich-119	54	15	for	for	ADP
biomedich-119	54	16	diabetes	diabetes	NOUN
biomedich-119	54	17	(	(	PUNCT
biomedich-119	54	18	ackeifi	ackeifi	PROPN
biomedich-119	54	19	et	et	PROPN
biomedich-119	54	20	al	al	PROPN
biomedich-119	54	21	.	.	PROPN
biomedich-119	54	22	,	,	PUNCT
biomedich-119	54	23	2020	2020	NUM
biomedich-119	54	24	)	)	PUNCT
biomedich-119	54	25	.	.	PUNCT
biomedich-119	55	1	through	through	ADP
biomedich-119	55	2	adulthood	adulthood	NOUN
biomedich-119	55	3	,	,	PUNCT
biomedich-119	55	4	β	β	X
biomedich-119	55	5	cell	cell	NOUN
biomedich-119	55	6	mass	mass	NOUN
biomedich-119	55	7	increasing	increase	VERB
biomedich-119	55	8	the	the	DET
biomedich-119	55	9	ability	ability	NOUN
biomedich-119	55	10	to	to	PART
biomedich-119	55	11	suit	suit	VERB
biomedich-119	55	12	peripheral	peripheral	ADJ
biomedich-119	55	13	requirements	requirement	NOUN
biomedich-119	55	14	.	.	PUNCT
biomedich-119	56	1	insufficient	insufficient	ADJ
biomedich-119	56	2	insulin	insulin	NOUN
biomedich-119	56	3	secretion	secretion	NOUN
biomedich-119	56	4	by	by	ADP
biomedich-119	56	5	β	β	NOUN
biomedich-119	56	6	cells	cell	NOUN
biomedich-119	56	7	leads	lead	VERB
biomedich-119	56	8	to	to	ADP
biomedich-119	56	9	mellitus	mellitus	PROPN
biomedich-119	56	10	diabetes	diabetes	PROPN
biomedich-119	56	11	(	(	PUNCT
biomedich-119	56	12	teta	teta	PROPN
biomedich-119	56	13	et	et	PROPN
biomedich-119	56	14	al	al	PROPN
biomedich-119	56	15	.	.	PROPN
biomedich-119	56	16	,	,	PUNCT
biomedich-119	56	17	2017	2017	NUM
biomedich-119	56	18	)	)	PUNCT
biomedich-119	56	19	.	.	PUNCT
biomedich-119	57	1	pancreatic	pancreatic	ADJ
biomedich-119	57	2	insulin	insulin	NOUN
biomedich-119	57	3	-	-	PUNCT
biomedich-119	57	4	producing	produce	VERB
biomedich-119	57	5	β	β	NOUN
biomedich-119	57	6	-	-	NOUN
biomedich-119	57	7	cells	cell	NOUN
biomedich-119	57	8	have	have	VERB
biomedich-119	57	9	a	a	DET
biomedich-119	57	10	long	long	ADJ
biomedich-119	57	11	lifespan	lifespan	NOUN
biomedich-119	57	12	,	,	PUNCT
biomedich-119	57	13	so	so	SCONJ
biomedich-119	57	14	they	they	PRON
biomedich-119	57	15	replicate	replicate	VERB
biomedich-119	57	16	very	very	ADV
biomedich-119	57	17	little	little	ADJ
biomedich-119	57	18	during	during	ADP
biomedich-119	57	19	a	a	DET
biomedich-119	57	20	lifetime	lifetime	NOUN
biomedich-119	57	21	in	in	ADP
biomedich-119	57	22	healthy	healthy	ADJ
biomedich-119	57	23	conditions	condition	NOUN
biomedich-119	57	24	(	(	PUNCT
biomedich-119	57	25	thorel	thorel	NOUN
biomedich-119	57	26	et	et	PROPN
biomedich-119	57	27	al	al	PROPN
biomedich-119	57	28	.	.	PROPN
biomedich-119	57	29	,	,	PUNCT
biomedich-119	57	30	2010	2010	NUM
biomedich-119	57	31	)	)	PUNCT
biomedich-119	57	32	.	.	PUNCT
biomedich-119	58	1	regeneration	regeneration	NOUN
biomedich-119	58	2	of	of	ADP
biomedich-119	58	3	pancreatic	pancreatic	ADJ
biomedich-119	58	4	β	β	NOUN
biomedich-119	58	5	-	-	NOUN
biomedich-119	58	6	cell	cell	NOUN
biomedich-119	58	7	mass	mass	NOUN
biomedich-119	58	8	following	follow	VERB
biomedich-119	58	9	either	either	CCONJ
biomedich-119	58	10	toxinor	toxinor	NOUN
biomedich-119	58	11	autoimmune	autoimmune	ADV
biomedich-119	58	12	-	-	PUNCT
biomedich-119	58	13	mediated	mediate	VERB
biomedich-119	58	14	destruction	destruction	NOUN
biomedich-119	58	15	in	in	ADP
biomedich-119	58	16	young	young	ADJ
biomedich-119	58	17	rodents	rodent	NOUN
biomedich-119	58	18	is	be	AUX
biomedich-119	58	19	probable	probable	ADJ
biomedich-119	58	20	,	,	PUNCT
biomedich-119	58	21	but	but	CCONJ
biomedich-119	58	22	the	the	DET
biomedich-119	58	23	degree	degree	NOUN
biomedich-119	58	24	of	of	ADP
biomedich-119	58	25	recovery	recovery	NOUN
biomedich-119	58	26	declines	decline	VERB
biomedich-119	58	27	with	with	ADP
biomedich-119	58	28	age	age	NOUN
biomedich-119	58	29	and	and	CCONJ
biomedich-119	58	30	is	be	AUX
biomedich-119	58	31	incomplete	incomplete	ADJ
biomedich-119	58	32	in	in	ADP
biomedich-119	58	33	adult	adult	NOUN
biomedich-119	58	34	life	life	NOUN
biomedich-119	58	35	.	.	PUNCT
biomedich-119	59	1	similarly	similarly	ADV
biomedich-119	59	2	,	,	PUNCT
biomedich-119	59	3	in	in	ADP
biomedich-119	59	4	children	child	NOUN
biomedich-119	59	5	and	and	CCONJ
biomedich-119	59	6	adolescents	adolescent	NOUN
biomedich-119	59	7	with	with	ADP
biomedich-119	59	8	type	type	NOUN
biomedich-119	59	9	1	1	NUM
biomedich-119	59	10	diabetes	diabete	NOUN
biomedich-119	59	11	,	,	PUNCT
biomedich-119	59	12	there	there	PRON
biomedich-119	59	13	is	be	VERB
biomedich-119	59	14	histological	histological	ADJ
biomedich-119	59	15	evidence	evidence	NOUN
biomedich-119	59	16	of	of	ADP
biomedich-119	59	17	islet	islet	NOUN
biomedich-119	59	18	cell	cell	NOUN
biomedich-119	59	19	smail	smail	NOUN
biomedich-119	59	20	–	–	PUNCT
biomedich-119	59	21	the	the	DET
biomedich-119	59	22	role	role	NOUN
biomedich-119	59	23	of	of	ADP
biomedich-119	59	24	gene	gene	NOUN
biomedich-119	59	25	therapy	therapy	NOUN
biomedich-119	59	26	in	in	ADP
biomedich-119	59	27	the	the	DET
biomedich-119	59	28	treatments	treatment	NOUN
biomedich-119	59	29	of	of	ADP
biomedich-119	59	30	…	…	PUNCT
biomedich-119	59	31	59	59	NUM
biomedich-119	59	32	neogenesis	neogenesis	NOUN
biomedich-119	59	33	and	and	CCONJ
biomedich-119	59	34	regenerative	regenerative	ADJ
biomedich-119	59	35	response	response	NOUN
biomedich-119	59	36	(	(	PUNCT
biomedich-119	59	37	thyssen	thyssen	PROPN
biomedich-119	59	38	et	et	PROPN
biomedich-119	59	39	al	al	PROPN
biomedich-119	59	40	.	.	PROPN
biomedich-119	59	41	,	,	PUNCT
biomedich-119	59	42	2006	2006	NUM
biomedich-119	59	43	)	)	PUNCT
biomedich-119	59	44	.	.	PUNCT
biomedich-119	60	1	single	single	ADJ
biomedich-119	60	2	-	-	PUNCT
biomedich-119	60	3	cell	cell	NOUN
biomedich-119	60	4	rna	rna	NOUN
biomedich-119	60	5	sequencing	sequence	VERB
biomedich-119	60	6	(	(	PUNCT
biomedich-119	60	7	scrna	scrna	NOUN
biomedich-119	60	8	-	-	PUNCT
biomedich-119	60	9	seq	seq	NOUN
biomedich-119	60	10	)	)	PUNCT
biomedich-119	60	11	of	of	ADP
biomedich-119	60	12	islets	islet	NOUN
biomedich-119	60	13	identified	identify	VERB
biomedich-119	60	14	β	β	NOUN
biomedich-119	60	15	-	-	NOUN
biomedich-119	60	16	cell	cell	NOUN
biomedich-119	60	17	dedifferentiation	dedifferentiation	NOUN
biomedich-119	60	18	and	and	CCONJ
biomedich-119	60	19	dysfunction	dysfunction	NOUN
biomedich-119	60	20	markers	marker	NOUN
biomedich-119	60	21	and	and	CCONJ
biomedich-119	60	22	pathways	pathway	NOUN
biomedich-119	60	23	(	(	PUNCT
biomedich-119	60	24	sachs	sachs	PROPN
biomedich-119	60	25	et	et	PROPN
biomedich-119	60	26	al	al	PROPN
biomedich-119	60	27	.	.	PROPN
biomedich-119	60	28	,	,	PUNCT
biomedich-119	60	29	2020	2020	NUM
biomedich-119	60	30	)	)	PUNCT
biomedich-119	60	31	.	.	PUNCT
biomedich-119	61	1	three	three	NUM
biomedich-119	61	2	regeneration	regeneration	NOUN
biomedich-119	61	3	modes	mode	NOUN
biomedich-119	61	4	were	be	AUX
biomedich-119	61	5	established	establish	VERB
biomedich-119	61	6	according	accord	VERB
biomedich-119	61	7	to	to	ADP
biomedich-119	61	8	the	the	DET
biomedich-119	61	9	various	various	ADJ
biomedich-119	61	10	cellular	cellular	ADJ
biomedich-119	61	11	regeneration	regeneration	NOUN
biomedich-119	61	12	origins	origin	NOUN
biomedich-119	61	13	.	.	PUNCT
biomedich-119	62	1	in	in	ADP
biomedich-119	62	2	the	the	DET
biomedich-119	62	3	first	first	ADJ
biomedich-119	62	4	mode	mode	NOUN
biomedich-119	62	5	,	,	PUNCT
biomedich-119	62	6	the	the	DET
biomedich-119	62	7	undifferentiated	undifferentiated	ADJ
biomedich-119	62	8	progenitor	progenitor	NOUN
biomedich-119	62	9	cells	cell	NOUN
biomedich-119	62	10	proliferate	proliferate	VERB
biomedich-119	62	11	and	and	CCONJ
biomedich-119	62	12	differentiate	differentiate	VERB
biomedich-119	62	13	as	as	ADP
biomedich-119	62	14	a	a	DET
biomedich-119	62	15	self	self	NOUN
biomedich-119	62	16	-	-	PUNCT
biomedich-119	62	17	renewing	renew	VERB
biomedich-119	62	18	source	source	NOUN
biomedich-119	62	19	in	in	ADP
biomedich-119	62	20	response	response	NOUN
biomedich-119	62	21	to	to	ADP
biomedich-119	62	22	injury	injury	NOUN
biomedich-119	62	23	to	to	PART
biomedich-119	62	24	repair	repair	VERB
biomedich-119	62	25	the	the	DET
biomedich-119	62	26	lost	lost	ADJ
biomedich-119	62	27	cell	cell	NOUN
biomedich-119	62	28	population	population	NOUN
biomedich-119	62	29	.	.	PUNCT
biomedich-119	63	1	the	the	DET
biomedich-119	63	2	second	second	ADJ
biomedich-119	63	3	mode	mode	NOUN
biomedich-119	63	4	,	,	PUNCT
biomedich-119	63	5	de	de	NOUN
biomedich-119	63	6	-	-	NOUN
biomedich-119	63	7	differentiate	differentiate	ADJ
biomedich-119	63	8	,	,	PUNCT
biomedich-119	63	9	and	and	CCONJ
biomedich-119	63	10	then	then	ADV
biomedich-119	63	11	proliferate	proliferate	VERB
biomedich-119	63	12	the	the	DET
biomedich-119	63	13	highly	highly	ADV
biomedich-119	63	14	defined	define	VERB
biomedich-119	63	15	remaining	remain	VERB
biomedich-119	63	16	cells	cell	NOUN
biomedich-119	63	17	(	(	PUNCT
biomedich-119	63	18	wang	wang	PROPN
biomedich-119	63	19	et	et	PROPN
biomedich-119	63	20	al	al	PROPN
biomedich-119	63	21	.	.	PROPN
biomedich-119	63	22	,	,	PUNCT
biomedich-119	63	23	2020	2020	NUM
biomedich-119	63	24	)	)	PUNCT
biomedich-119	63	25	.	.	PUNCT
biomedich-119	64	1	regeneration	regeneration	NOUN
biomedich-119	64	2	of	of	ADP
biomedich-119	64	3	lost	lost	ADJ
biomedich-119	64	4	or	or	CCONJ
biomedich-119	64	5	dysfunctional	dysfunctional	ADJ
biomedich-119	64	6	islet	islet	NOUN
biomedich-119	64	7	β	β	X
biomedich-119	64	8	cells	cell	NOUN
biomedich-119	64	9	in	in	ADP
biomedich-119	64	10	vivo	vivo	NOUN
biomedich-119	64	11	can	can	AUX
biomedich-119	64	12	fulfill	fulfill	VERB
biomedich-119	64	13	the	the	DET
biomedich-119	64	14	promise	promise	NOUN
biomedich-119	64	15	of	of	ADP
biomedich-119	64	16	improved	improved	ADJ
biomedich-119	64	17	treatment	treatment	NOUN
biomedich-119	64	18	for	for	ADP
biomedich-119	64	19	patients	patient	NOUN
biomedich-119	64	20	with	with	ADP
biomedich-119	64	21	diabetes	diabetes	NOUN
biomedich-119	64	22	.	.	PUNCT
biomedich-119	65	1	numerous	numerous	ADJ
biomedich-119	65	2	mitogenic	mitogenic	ADJ
biomedich-119	65	3	factors	factor	NOUN
biomedich-119	65	4	have	have	AUX
biomedich-119	65	5	been	be	AUX
biomedich-119	65	6	attempted	attempt	VERB
biomedich-119	65	7	to	to	PART
biomedich-119	65	8	achieve	achieve	VERB
biomedich-119	65	9	this	this	PRON
biomedich-119	65	10	,	,	PUNCT
biomedich-119	65	11	including	include	VERB
biomedich-119	65	12	gammaaminobutyric	gammaaminobutyric	ADJ
biomedich-119	65	13	acid	acid	NOUN
biomedich-119	65	14	(	(	PUNCT
biomedich-119	65	15	gaba	gaba	PROPN
biomedich-119	65	16	)	)	PUNCT
biomedich-119	65	17	(	(	PUNCT
biomedich-119	65	18	yi	yi	NOUN
biomedich-119	65	19	et	et	PROPN
biomedich-119	65	20	al	al	PROPN
biomedich-119	65	21	.	.	PROPN
biomedich-119	65	22	,	,	PUNCT
biomedich-119	65	23	2020	2020	NUM
biomedich-119	65	24	)	)	PUNCT
biomedich-119	65	25	.	.	PUNCT
biomedich-119	66	1	results	result	NOUN
biomedich-119	66	2	indicate	indicate	VERB
biomedich-119	66	3	that	that	SCONJ
biomedich-119	66	4	curcumin	curcumin	NOUN
biomedich-119	66	5	has	have	VERB
biomedich-119	66	6	anti	anti	ADJ
biomedich-119	66	7	-	-	ADJ
biomedich-119	66	8	diabetic	diabetic	ADJ
biomedich-119	66	9	properties	property	NOUN
biomedich-119	66	10	because	because	SCONJ
biomedich-119	66	11	of	of	ADP
biomedich-119	66	12	its	its	PRON
biomedich-119	66	13	superior	superior	ADJ
biomedich-119	66	14	immunomodulatory	immunomodulatory	ADJ
biomedich-119	66	15	behavior	behavior	NOUN
biomedich-119	66	16	on	on	ADP
biomedich-119	66	17	t	t	PROPN
biomedich-119	66	18	-	-	PUNCT
biomedich-119	66	19	associated	associate	VERB
biomedich-119	66	20	cytokines	cytokine	NOUN
biomedich-119	66	21	and	and	CCONJ
biomedich-119	66	22	immunosuppressive	immunosuppressive	ADJ
biomedich-119	66	23	activity	activity	NOUN
biomedich-119	66	24	on	on	ADP
biomedich-119	66	25	pro	pro	ADJ
biomedich-119	66	26	-	-	ADJ
biomedich-119	66	27	inflammatory	inflammatory	ADJ
biomedich-119	66	28	cytokines	cytokine	NOUN
biomedich-119	66	29	may	may	AUX
biomedich-119	66	30	enhance	enhance	VERB
biomedich-119	66	31	damage	damage	NOUN
biomedich-119	66	32	to	to	ADP
biomedich-119	66	33	pancreatic	pancreatic	ADJ
biomedich-119	66	34	β	β	X
biomedich-119	66	35	cells	cell	NOUN
biomedich-119	66	36	(	(	PUNCT
biomedich-119	66	37	badr	badr	PROPN
biomedich-119	66	38	et	et	PROPN
biomedich-119	66	39	al	al	PROPN
biomedich-119	66	40	.	.	PROPN
biomedich-119	66	41	,	,	PUNCT
biomedich-119	66	42	2020	2020	NUM
biomedich-119	66	43	)	)	PUNCT
biomedich-119	66	44	.	.	PUNCT
biomedich-119	67	1	proliferation	proliferation	NOUN
biomedich-119	67	2	is	be	AUX
biomedich-119	67	3	the	the	DET
biomedich-119	67	4	primary	primary	ADJ
biomedich-119	67	5	mechanism	mechanism	NOUN
biomedich-119	67	6	of	of	ADP
biomedich-119	67	7	b	b	NOUN
biomedich-119	67	8	-	-	PUNCT
biomedich-119	67	9	cell	cell	NOUN
biomedich-119	67	10	expansion	expansion	NOUN
biomedich-119	67	11	during	during	ADP
biomedich-119	67	12	the	the	DET
biomedich-119	67	13	early	early	ADJ
biomedich-119	67	14	postnatal	postnatal	ADJ
biomedich-119	67	15	period	period	NOUN
biomedich-119	67	16	to	to	PART
biomedich-119	67	17	produce	produce	VERB
biomedich-119	67	18	sufficient	sufficient	ADJ
biomedich-119	67	19	b	b	NOUN
biomedich-119	67	20	-	-	PUNCT
biomedich-119	67	21	cell	cell	NOUN
biomedich-119	67	22	mass	mass	NOUN
biomedich-119	67	23	in	in	ADP
biomedich-119	67	24	an	an	DET
biomedich-119	67	25	organism	organism	NOUN
biomedich-119	67	26	.	.	PUNCT
biomedich-119	68	1	however	however	ADV
biomedich-119	68	2	,	,	PUNCT
biomedich-119	68	3	the	the	DET
biomedich-119	68	4	proliferation	proliferation	NOUN
biomedich-119	68	5	of	of	ADP
biomedich-119	68	6	b	b	NOUN
biomedich-119	68	7	cells	cell	NOUN
biomedich-119	68	8	declines	decline	VERB
biomedich-119	68	9	rapidly	rapidly	ADV
biomedich-119	68	10	in	in	ADP
biomedich-119	68	11	early	early	ADJ
biomedich-119	68	12	life	life	NOUN
biomedich-119	68	13	,	,	PUNCT
biomedich-119	68	14	and	and	CCONJ
biomedich-119	68	15	the	the	DET
biomedich-119	68	16	rate	rate	NOUN
biomedich-119	68	17	of	of	ADP
biomedich-119	68	18	division	division	NOUN
biomedich-119	68	19	of	of	ADP
biomedich-119	68	20	b	b	NOUN
biomedich-119	68	21	cells	cell	NOUN
biomedich-119	68	22	in	in	ADP
biomedich-119	68	23	adults	adult	NOUN
biomedich-119	68	24	is	be	AUX
biomedich-119	68	25	very	very	ADV
biomedich-119	68	26	low	low	ADJ
biomedich-119	68	27	(	(	PUNCT
biomedich-119	68	28	guney	guney	NOUN
biomedich-119	68	29	et	et	PROPN
biomedich-119	68	30	al	al	PROPN
biomedich-119	68	31	.	.	PROPN
biomedich-119	68	32	,	,	PUNCT
biomedich-119	68	33	2020	2020	NUM
biomedich-119	68	34	)	)	PUNCT
biomedich-119	68	35	.	.	PUNCT
biomedich-119	69	1	however	however	ADV
biomedich-119	69	2	,	,	PUNCT
biomedich-119	69	3	there	there	PRON
biomedich-119	69	4	is	be	VERB
biomedich-119	69	5	still	still	ADV
biomedich-119	69	6	a	a	DET
biomedich-119	69	7	great	great	ADJ
biomedich-119	69	8	need	need	NOUN
biomedich-119	69	9	for	for	ADP
biomedich-119	69	10	new	new	ADJ
biomedich-119	69	11	treatments	treatment	NOUN
biomedich-119	69	12	,	,	PUNCT
biomedich-119	69	13	as	as	SCONJ
biomedich-119	69	14	tid	tid	NOUN
biomedich-119	69	15	remains	remain	VERB
biomedich-119	69	16	an	an	DET
biomedich-119	69	17	incurable	incurable	ADJ
biomedich-119	69	18	illness	illness	NOUN
biomedich-119	69	19	.	.	PUNCT
biomedich-119	70	1	natural	natural	ADJ
biomedich-119	70	2	products	product	NOUN
biomedich-119	70	3	,	,	PUNCT
biomedich-119	70	4	primarily	primarily	ADV
biomedich-119	70	5	phytochemicals	phytochemical	NOUN
biomedich-119	70	6	,	,	PUNCT
biomedich-119	70	7	are	be	AUX
biomedich-119	70	8	a	a	DET
biomedich-119	70	9	tremendous	tremendous	ADJ
biomedich-119	70	10	source	source	NOUN
biomedich-119	70	11	of	of	ADP
biomedich-119	70	12	drug	drug	NOUN
biomedich-119	70	13	lead	lead	NOUN
biomedich-119	70	14	discovery	discovery	NOUN
biomedich-119	70	15	for	for	ADP
biomedich-119	70	16	diabetes	diabetes	NOUN
biomedich-119	70	17	(	(	PUNCT
biomedich-119	70	18	apaya	apaya	NOUN
biomedich-119	70	19	et	et	PROPN
biomedich-119	70	20	al	al	PROPN
biomedich-119	70	21	.	.	PROPN
biomedich-119	70	22	,	,	PUNCT
biomedich-119	70	23	2020	2020	NUM
biomedich-119	70	24	)	)	PUNCT
biomedich-119	70	25	.	.	PUNCT
biomedich-119	71	1	nevertheless	nevertheless	ADV
biomedich-119	71	2	,	,	PUNCT
biomedich-119	71	3	conventional	conventional	ADJ
biomedich-119	71	4	cell	cell	NOUN
biomedich-119	71	5	-	-	PUNCT
biomedich-119	71	6	based	base	VERB
biomedich-119	71	7	research	research	NOUN
biomedich-119	71	8	approaches	approach	NOUN
biomedich-119	71	9	have	have	VERB
biomedich-119	71	10	weaknesses	weakness	NOUN
biomedich-119	71	11	in	in	ADP
biomedich-119	71	12	identifying	identify	VERB
biomedich-119	71	13	the	the	DET
biomedich-119	71	14	precise	precise	ADJ
biomedich-119	71	15	processes	process	NOUN
biomedich-119	71	16	of	of	ADP
biomedich-119	71	17	β	β	NOUN
biomedich-119	71	18	-	-	NOUN
biomedich-119	71	19	cell	cell	NOUN
biomedich-119	71	20	differentiation	differentiation	NOUN
biomedich-119	71	21	and	and	CCONJ
biomedich-119	71	22	transdifferentiation	transdifferentiation	NOUN
biomedich-119	71	23	,	,	PUNCT
biomedich-119	71	24	as	as	ADV
biomedich-119	71	25	well	well	ADV
biomedich-119	71	26	as	as	ADP
biomedich-119	71	27	the	the	DET
biomedich-119	71	28	related	relate	VERB
biomedich-119	71	29	regulatory	regulatory	ADJ
biomedich-119	71	30	mechanisms	mechanism	NOUN
biomedich-119	71	31	(	(	PUNCT
biomedich-119	71	32	yu	yu	PROPN
biomedich-119	71	33	and	and	CCONJ
biomedich-119	71	34	xu	xu	PROPN
biomedich-119	71	35	,	,	PUNCT
biomedich-119	71	36	2020	2020	NUM
biomedich-119	71	37	)	)	PUNCT
biomedich-119	71	38	.	.	PUNCT
biomedich-119	72	1	data	datum	NOUN
biomedich-119	72	2	cumulated	cumulate	VERB
biomedich-119	72	3	over	over	ADP
biomedich-119	72	4	the	the	DET
biomedich-119	72	5	past	past	ADJ
biomedich-119	72	6	few	few	ADJ
biomedich-119	72	7	years	year	NOUN
biomedich-119	72	8	suggest	suggest	VERB
biomedich-119	72	9	that	that	SCONJ
biomedich-119	72	10	increased	increase	VERB
biomedich-119	72	11	β	β	NOUN
biomedich-119	72	12	-	-	NOUN
biomedich-119	72	13	cell	cell	NOUN
biomedich-119	72	14	dedifferentiation	dedifferentiation	NOUN
biomedich-119	72	15	plays	play	VERB
biomedich-119	72	16	a	a	DET
biomedich-119	72	17	crucial	crucial	ADJ
biomedich-119	72	18	role	role	NOUN
biomedich-119	72	19	in	in	ADP
biomedich-119	72	20	diabetes	diabetes	NOUN
biomedich-119	72	21	progression	progression	NOUN
biomedich-119	72	22	,	,	PUNCT
biomedich-119	72	23	shedding	shed	VERB
biomedich-119	72	24	new	new	ADJ
biomedich-119	72	25	light	light	NOUN
biomedich-119	72	26	on	on	ADP
biomedich-119	72	27	potential	potential	ADJ
biomedich-119	72	28	targets	target	NOUN
biomedich-119	72	29	for	for	ADP
biomedich-119	72	30	β	β	NOUN
biomedich-119	72	31	-	-	ADJ
biomedich-119	72	32	cell	cell	NOUN
biomedich-119	72	33	replacement	replacement	NOUN
biomedich-119	72	34	therapy	therapy	NOUN
biomedich-119	72	35	(	(	PUNCT
biomedich-119	72	36	zhang	zhang	PROPN
biomedich-119	72	37	et	et	PROPN
biomedich-119	72	38	al	al	PROPN
biomedich-119	72	39	.	.	PROPN
biomedich-119	72	40	,	,	PUNCT
biomedich-119	72	41	2020	2020	NUM
biomedich-119	72	42	)	)	PUNCT
biomedich-119	72	43	.	.	PUNCT
biomedich-119	73	1	based	base	VERB
biomedich-119	73	2	on	on	ADP
biomedich-119	73	3	a	a	DET
biomedich-119	73	4	new	new	ADJ
biomedich-119	73	5	understanding	understanding	NOUN
biomedich-119	73	6	of	of	ADP
biomedich-119	73	7	structural	structural	ADJ
biomedich-119	73	8	and	and	CCONJ
biomedich-119	73	9	functional	functional	ADJ
biomedich-119	73	10	dynamics	dynamic	NOUN
biomedich-119	73	11	of	of	ADP
biomedich-119	73	12	the	the	DET
biomedich-119	73	13	bone	bone	NOUN
biomedich-119	73	14	marrow	marrow	NOUN
biomedich-119	73	15	,	,	PUNCT
biomedich-119	73	16	a	a	DET
biomedich-119	73	17	conditioning	conditioning	NOUN
biomedich-119	73	18	-	-	PUNCT
biomedich-119	73	19	free	free	ADJ
biomedich-119	73	20	bone	bone	NOUN
biomedich-119	73	21	marrow	marrow	NOUN
biomedich-119	73	22	transplantation	transplantation	NOUN
biomedich-119	73	23	(	(	PUNCT
biomedich-119	73	24	bmt	bmt	NOUN
biomedich-119	73	25	)	)	PUNCT
biomedich-119	73	26	with	with	ADP
biomedich-119	73	27	reduced	reduced	ADJ
biomedich-119	73	28	adverse	adverse	ADJ
biomedich-119	73	29	effects	effect	NOUN
biomedich-119	73	30	opens	open	VERB
biomedich-119	73	31	the	the	DET
biomedich-119	73	32	possibility	possibility	NOUN
biomedich-119	73	33	of	of	ADP
biomedich-119	73	34	evaluating	evaluate	VERB
biomedich-119	73	35	β	β	PROPN
biomedich-119	73	36	cell	cell	NOUN
biomedich-119	73	37	regeneration	regeneration	NOUN
biomedich-119	73	38	and	and	CCONJ
biomedich-119	73	39	euglycemic	euglycemic	ADJ
biomedich-119	73	40	restoration	restoration	NOUN
biomedich-119	73	41	by	by	ADP
biomedich-119	73	42	inducing	induce	VERB
biomedich-119	73	43	allogeneic	allogeneic	ADJ
biomedich-119	73	44	chimerism	chimerism	NOUN
biomedich-119	73	45	in	in	ADP
biomedich-119	73	46	t1	t1	PROPN
biomedich-119	73	47	dm	dm	PROPN
biomedich-119	73	48	patients	patient	NOUN
biomedich-119	73	49	,	,	PUNCT
biomedich-119	73	50	as	as	SCONJ
biomedich-119	73	51	shown	show	VERB
biomedich-119	73	52	in	in	ADP
biomedich-119	73	53	a	a	DET
biomedich-119	73	54	mouse	mouse	NOUN
biomedich-119	73	55	model	model	NOUN
biomedich-119	73	56	(	(	PUNCT
biomedich-119	73	57	black	black	ADJ
biomedich-119	73	58	and	and	CCONJ
biomedich-119	73	59	zorina	zorina	NOUN
biomedich-119	73	60	,	,	PUNCT
biomedich-119	73	61	2020	2020	NUM
biomedich-119	73	62	)	)	PUNCT
biomedich-119	73	63	.	.	PUNCT
biomedich-119	74	1	a	a	DET
biomedich-119	74	2	new	new	ADJ
biomedich-119	74	3	study	study	NOUN
biomedich-119	74	4	now	now	ADV
biomedich-119	74	5	shows	show	VERB
biomedich-119	74	6	that	that	SCONJ
biomedich-119	74	7	a	a	DET
biomedich-119	74	8	pharmacological	pharmacological	ADJ
biomedich-119	74	9	combination	combination	NOUN
biomedich-119	74	10	of	of	ADP
biomedich-119	74	11	insulin	insulin	NOUN
biomedich-119	74	12	and	and	CCONJ
biomedich-119	74	13	glp-1	glp-1	NOUN
biomedich-119	74	14	–	–	PUNCT
biomedich-119	74	15	estrogen	estrogen	NOUN
biomedich-119	74	16	conjugate	conjugate	NOUN
biomedich-119	74	17	not	not	PART
biomedich-119	74	18	only	only	ADV
biomedich-119	74	19	decreases	decrease	VERB
biomedich-119	74	20	the	the	DET
biomedich-119	74	21	daily	daily	ADJ
biomedich-119	74	22	requirements	requirement	NOUN
biomedich-119	74	23	for	for	ADP
biomedich-119	74	24	insulin	insulin	NOUN
biomedich-119	74	25	but	but	CCONJ
biomedich-119	74	26	also	also	ADV
biomedich-119	74	27	improves	improve	VERB
biomedich-119	74	28	β	β	NOUN
biomedich-119	74	29	-	-	ADJ
biomedich-119	74	30	cell	cell	NOUN
biomedich-119	74	31	function	function	NOUN
biomedich-119	74	32	(	(	PUNCT
biomedich-119	74	33	de	de	X
biomedich-119	74	34	et	et	PROPN
biomedich-119	74	35	al	al	PROPN
biomedich-119	74	36	.	.	PROPN
biomedich-119	74	37	,	,	PUNCT
biomedich-119	74	38	2020	2020	NUM
biomedich-119	74	39	)	)	PUNCT
biomedich-119	74	40	.	.	PUNCT
biomedich-119	75	1	lif	lif	PROPN
biomedich-119	75	2	receptor	receptor	NOUN
biomedich-119	75	3	expression	expression	NOUN
biomedich-119	75	4	is	be	AUX
biomedich-119	75	5	limited	limit	VERB
biomedich-119	75	6	to	to	ADP
biomedich-119	75	7	a	a	DET
biomedich-119	75	8	subset	subset	NOUN
biomedich-119	75	9	of	of	ADP
biomedich-119	75	10	transcriptionally	transcriptionally	ADV
biomedich-119	75	11	isolated	isolate	VERB
biomedich-119	75	12	human	human	ADJ
biomedich-119	75	13	β	β	NOUN
biomedich-119	75	14	cells	cell	NOUN
biomedich-119	75	15	with	with	ADP
biomedich-119	75	16	the	the	DET
biomedich-119	75	17	enhanced	enhanced	ADJ
biomedich-119	75	18	proliferative	proliferative	ADJ
biomedich-119	75	19	ability	ability	NOUN
biomedich-119	75	20	(	(	PUNCT
biomedich-119	75	21	rosado	rosado	NOUN
biomedich-119	75	22	et	et	PROPN
biomedich-119	75	23	al	al	PROPN
biomedich-119	75	24	.	.	PROPN
biomedich-119	75	25	,	,	PUNCT
biomedich-119	75	26	2020	2020	NUM
biomedich-119	75	27	)	)	PUNCT
biomedich-119	75	28	.	.	PUNCT
biomedich-119	76	1	residual	residual	ADJ
biomedich-119	76	2	β	β	X
biomedich-119	76	3	-	-	NOUN
biomedich-119	76	4	cells	cell	NOUN
biomedich-119	76	5	play	play	VERB
biomedich-119	76	6	a	a	DET
biomedich-119	76	7	major	major	ADJ
biomedich-119	76	8	role	role	NOUN
biomedich-119	76	9	in	in	ADP
biomedich-119	76	10	the	the	DET
biomedich-119	76	11	design	design	NOUN
biomedich-119	76	12	of	of	ADP
biomedich-119	76	13	clinical	clinical	ADJ
biomedich-119	76	14	trials	trial	NOUN
biomedich-119	76	15	:	:	PUNCT
biomedich-119	76	16	they	they	PRON
biomedich-119	76	17	may	may	AUX
biomedich-119	76	18	not	not	PART
biomedich-119	76	19	only	only	ADV
biomedich-119	76	20	respond	respond	VERB
biomedich-119	76	21	to	to	ADP
biomedich-119	76	22	combination	combination	NOUN
biomedich-119	76	23	therapies	therapy	NOUN
biomedich-119	76	24	that	that	PRON
biomedich-119	76	25	involve	involve	VERB
biomedich-119	76	26	metabolic	metabolic	NOUN
biomedich-119	76	27	function	function	NOUN
biomedich-119	76	28	stimulants	stimulant	NOUN
biomedich-119	76	29	but	but	CCONJ
biomedich-119	76	30	are	be	AUX
biomedich-119	76	31	also	also	ADV
biomedich-119	76	32	the	the	DET
biomedich-119	76	33	possible	possible	ADJ
biomedich-119	76	34	source	source	NOUN
biomedich-119	76	35	of	of	ADP
biomedich-119	76	36	new	new	ADJ
biomedich-119	76	37	β	β	NOUN
biomedich-119	76	38	-	-	NOUN
biomedich-119	76	39	cells	cell	NOUN
biomedich-119	76	40	(	(	PUNCT
biomedich-119	76	41	akirav	akirav	NOUN
biomedich-119	76	42	et	et	PROPN
biomedich-119	76	43	al	al	PROPN
biomedich-119	76	44	.	.	PROPN
biomedich-119	76	45	,	,	PUNCT
biomedich-119	76	46	2018	2018	NUM
biomedich-119	76	47	)	)	PUNCT
biomedich-119	76	48	.	.	PUNCT
biomedich-119	77	1	insulin	insulin	NOUN
biomedich-119	77	2	gene	gene	NOUN
biomedich-119	77	3	therapy	therapy	NOUN
biomedich-119	77	4	insulin	insulin	NOUN
biomedich-119	77	5	treatment	treatment	NOUN
biomedich-119	77	6	options	option	NOUN
biomedich-119	77	7	for	for	ADP
biomedich-119	77	8	type	type	NOUN
biomedich-119	77	9	1	1	NUM
biomedich-119	77	10	and	and	CCONJ
biomedich-119	77	11	type	type	NOUN
biomedich-119	77	12	2	2	NUM
biomedich-119	77	13	diabetics	diabetic	NOUN
biomedich-119	77	14	have	have	AUX
biomedich-119	77	15	increased	increase	VERB
biomedich-119	77	16	since	since	SCONJ
biomedich-119	77	17	the	the	DET
biomedich-119	77	18	launch	launch	NOUN
biomedich-119	77	19	of	of	ADP
biomedich-119	77	20	the	the	DET
biomedich-119	77	21	insulin	insulin	NOUN
biomedich-119	77	22	analogs	analog	NOUN
biomedich-119	77	23	in	in	ADP
biomedich-119	77	24	1996	1996	NUM
biomedich-119	77	25	.	.	PUNCT
biomedich-119	78	1	insulin	insulin	NOUN
biomedich-119	78	2	therapies	therapy	NOUN
biomedich-119	78	3	are	be	AUX
biomedich-119	78	4	now	now	ADV
biomedich-119	78	5	able	able	ADJ
biomedich-119	78	6	to	to	PART
biomedich-119	78	7	mimic	mimic	VERB
biomedich-119	78	8	the	the	DET
biomedich-119	78	9	physiological	physiological	ADJ
biomedich-119	78	10	insulin	insulin	NOUN
biomedich-119	78	11	secretion	secretion	NOUN
biomedich-119	78	12	more	more	ADV
biomedich-119	78	13	closely	closely	ADV
biomedich-119	78	14	and	and	CCONJ
biomedich-119	78	15	thus	thus	ADV
biomedich-119	78	16	achieve	achieve	VERB
biomedich-119	78	17	better	well	ADJ
biomedich-119	78	18	glycemic	glycemic	ADJ
biomedich-119	78	19	control	control	NOUN
biomedich-119	78	20	in	in	ADP
biomedich-119	78	21	diabetes	diabetes	NOUN
biomedich-119	78	22	patients	patient	NOUN
biomedich-119	78	23	(	(	PUNCT
biomedich-119	78	24	donner	donner	PROPN
biomedich-119	78	25	et	et	PROPN
biomedich-119	78	26	al	al	PROPN
biomedich-119	78	27	.	.	PROPN
biomedich-119	78	28	,	,	PUNCT
biomedich-119	78	29	2019	2019	NUM
biomedich-119	78	30	)	)	PUNCT
biomedich-119	78	31	.	.	PUNCT
biomedich-119	79	1	gene	gene	NOUN
biomedich-119	79	2	therapy	therapy	NOUN
biomedich-119	79	3	is	be	AUX
biomedich-119	79	4	one	one	NUM
biomedich-119	79	5	of	of	ADP
biomedich-119	79	6	the	the	DET
biomedich-119	79	7	diabetes	diabetes	NOUN
biomedich-119	79	8	mellitus	mellitus	NOUN
biomedich-119	79	9	treatment	treatment	NOUN
biomedich-119	79	10	methods	method	NOUN
biomedich-119	79	11	(	(	PUNCT
biomedich-119	79	12	ramezani	ramezani	NOUN
biomedich-119	79	13	et	et	PROPN
biomedich-119	79	14	al	al	PROPN
biomedich-119	79	15	.	.	PROPN
biomedich-119	79	16	,	,	PUNCT
biomedich-119	79	17	2019	2019	NUM
biomedich-119	79	18	)	)	PUNCT
biomedich-119	79	19	.	.	PUNCT
biomedich-119	80	1	the	the	DET
biomedich-119	80	2	two	two	NUM
biomedich-119	80	3	key	key	ADJ
biomedich-119	80	4	issues	issue	NOUN
biomedich-119	80	5	are	be	AUX
biomedich-119	80	6	efficacy	efficacy	NOUN
biomedich-119	80	7	and	and	CCONJ
biomedich-119	80	8	safety	safety	NOUN
biomedich-119	80	9	in	in	ADP
biomedich-119	80	10	developing	develop	VERB
biomedich-119	80	11	insulin	insulin	NOUN
biomedich-119	80	12	-	-	PUNCT
biomedich-119	80	13	replacement	replacement	NOUN
biomedich-119	80	14	gene	gene	NOUN
biomedich-119	80	15	therapy	therapy	NOUN
biomedich-119	80	16	as	as	ADP
biomedich-119	80	17	a	a	DET
biomedich-119	80	18	possible	possible	ADJ
biomedich-119	80	19	treatment	treatment	NOUN
biomedich-119	80	20	for	for	ADP
biomedich-119	80	21	type	type	NOUN
biomedich-119	80	22	1	1	NUM
biomedich-119	80	23	diabetes	diabetes	NOUN
biomedich-119	80	24	.	.	PUNCT
biomedich-119	81	1	in	in	ADP
biomedich-119	81	2	addition	addition	NOUN
biomedich-119	81	3	to	to	ADP
biomedich-119	81	4	using	use	VERB
biomedich-119	81	5	a	a	DET
biomedich-119	81	6	safe	safe	ADJ
biomedich-119	81	7	and	and	CCONJ
biomedich-119	81	8	efficient	efficient	ADJ
biomedich-119	81	9	gene	gene	NOUN
biomedich-119	81	10	transfer	transfer	NOUN
biomedich-119	81	11	vector	vector	NOUN
biomedich-119	81	12	,	,	PUNCT
biomedich-119	81	13	the	the	DET
biomedich-119	81	14	physiological	physiological	ADJ
biomedich-119	81	15	regulation	regulation	NOUN
biomedich-119	81	16	of	of	ADP
biomedich-119	81	17	the	the	DET
biomedich-119	81	18	expression	expression	NOUN
biomedich-119	81	19	of	of	ADP
biomedich-119	81	20	the	the	DET
biomedich-119	81	21	insulin	insulin	NOUN
biomedich-119	81	22	gene	gene	NOUN
biomedich-119	81	23	is	be	AUX
biomedich-119	81	24	important	important	ADJ
biomedich-119	81	25	(	(	PUNCT
biomedich-119	81	26	chen	chen	PROPN
biomedich-119	81	27	et	et	PROPN
biomedich-119	81	28	al	al	PROPN
biomedich-119	81	29	.	.	PROPN
biomedich-119	81	30	,	,	PUNCT
biomedich-119	81	31	2011	2011	NUM
biomedich-119	81	32	)	)	PUNCT
biomedich-119	81	33	.	.	PUNCT
biomedich-119	82	1	insulin	insulin	NOUN
biomedich-119	82	2	gene	gene	NOUN
biomedich-119	82	3	therapy	therapy	NOUN
biomedich-119	82	4	refers	refer	VERB
biomedich-119	82	5	to	to	ADP
biomedich-119	82	6	the	the	DET
biomedich-119	82	7	targeted	target	VERB
biomedich-119	82	8	expression	expression	NOUN
biomedich-119	82	9	of	of	ADP
biomedich-119	82	10	insulin	insulin	NOUN
biomedich-119	82	11	in	in	ADP
biomedich-119	82	12	non	non	ADJ
biomedich-119	82	13	-	-	ADJ
biomedich-119	82	14	β	β	ADJ
biomedich-119	82	15	cells	cell	NOUN
biomedich-119	82	16	,	,	PUNCT
biomedich-119	82	17	the	the	DET
biomedich-119	82	18	primary	primary	ADJ
biomedich-119	82	19	therapeutic	therapeutic	ADJ
biomedich-119	82	20	target	target	NOUN
biomedich-119	82	21	being	be	AUX
biomedich-119	82	22	hepatocytes	hepatocyte	NOUN
biomedich-119	82	23	(	(	PUNCT
biomedich-119	82	24	handorf	handorf	PROPN
biomedich-119	82	25	et	et	PROPN
biomedich-119	82	26	al	al	PROPN
biomedich-119	82	27	.	.	PROPN
biomedich-119	82	28	,	,	PUNCT
biomedich-119	82	29	2015	2015	NUM
biomedich-119	82	30	)	)	PUNCT
biomedich-119	82	31	.	.	PUNCT
biomedich-119	83	1	the	the	DET
biomedich-119	83	2	human	human	ADJ
biomedich-119	83	3	insulin	insulin	NOUN
biomedich-119	83	4	gene	gene	NOUN
biomedich-119	83	5	wrapped	wrap	VERB
biomedich-119	83	6	in	in	ADP
biomedich-119	83	7	chitosan	chitosan	ADJ
biomedich-119	83	8	nanoparticles	nanoparticle	NOUN
biomedich-119	83	9	can	can	AUX
biomedich-119	83	10	be	be	AUX
biomedich-119	83	11	successfully	successfully	ADV
biomedich-119	83	12	transfected	transfecte	VERB
biomedich-119	83	13	through	through	ADP
biomedich-119	83	14	the	the	DET
biomedich-119	83	15	gastrointestinal	gastrointestinal	ADJ
biomedich-119	83	16	tract	tract	NOUN
biomedich-119	83	17	into	into	ADP
biomedich-119	83	18	rats	rat	NOUN
biomedich-119	83	19	(	(	PUNCT
biomedich-119	83	20	niu	niu	PROPN
biomedich-119	83	21	et	et	PROPN
biomedich-119	83	22	al	al	PROPN
biomedich-119	83	23	.	.	PROPN
biomedich-119	83	24	,	,	PUNCT
biomedich-119	83	25	2008	2008	NUM
biomedich-119	83	26	)	)	PUNCT
biomedich-119	83	27	.	.	PUNCT
biomedich-119	84	1	differentiation	differentiation	NOUN
biomedich-119	84	2	between	between	ADP
biomedich-119	84	3	adsc	adsc	ADJ
biomedich-119	84	4	and	and	CCONJ
biomedich-119	84	5	tissue	tissue	NOUN
biomedich-119	84	6	-	-	PUNCT
biomedich-119	84	7	specific	specific	ADJ
biomedich-119	84	8	promoters	promoter	NOUN
biomedich-119	84	9	will	will	AUX
biomedich-119	84	10	improve	improve	VERB
biomedich-119	84	11	the	the	DET
biomedich-119	84	12	therapeutic	therapeutic	ADJ
biomedich-119	84	13	gene	gene	NOUN
biomedich-119	84	14	expression	expression	NOUN
biomedich-119	84	15	.	.	PUNCT
biomedich-119	85	1	the	the	DET
biomedich-119	85	2	use	use	NOUN
biomedich-119	85	3	of	of	ADP
biomedich-119	85	4	microcarriers	microcarrier	NOUN
biomedich-119	85	5	can	can	AUX
biomedich-119	85	6	facilitate	facilitate	VERB
biomedich-119	85	7	posttransplantation	posttransplantation	NOUN
biomedich-119	85	8	cell	cell	NOUN
biomedich-119	85	9	survival	survival	NOUN
biomedich-119	85	10	and	and	CCONJ
biomedich-119	85	11	hold	hold	VERB
biomedich-119	85	12	potential	potential	NOUN
biomedich-119	85	13	for	for	ADP
biomedich-119	85	14	longterm	longterm	ADJ
biomedich-119	85	15	cell	cell	NOUN
biomedich-119	85	16	therapy	therapy	NOUN
biomedich-119	85	17	(	(	PUNCT
biomedich-119	85	18	fang	fang	X
biomedich-119	85	19	et	et	PROPN
biomedich-119	85	20	al	al	PROPN
biomedich-119	85	21	.	.	PROPN
biomedich-119	85	22	,	,	PUNCT
biomedich-119	85	23	2019	2019	NUM
biomedich-119	85	24	)	)	PUNCT
biomedich-119	85	25	.	.	PUNCT
biomedich-119	86	1	insulin	insulin	NOUN
biomedich-119	86	2	-	-	PUNCT
biomedich-119	86	3	producing	produce	VERB
biomedich-119	86	4	cell	cell	NOUN
biomedich-119	86	5	replacement	replacement	NOUN
biomedich-119	86	6	through	through	ADP
biomedich-119	86	7	transplantation	transplantation	NOUN
biomedich-119	86	8	shows	show	VERB
biomedich-119	86	9	significant	significant	ADJ
biomedich-119	86	10	promise	promise	NOUN
biomedich-119	86	11	but	but	CCONJ
biomedich-119	86	12	is	be	AUX
biomedich-119	86	13	limited	limit	VERB
biomedich-119	86	14	in	in	ADP
biomedich-119	86	15	application	application	NOUN
biomedich-119	86	16	due	due	ADP
biomedich-119	86	17	to	to	ADP
biomedich-119	86	18	supply	supply	NOUN
biomedich-119	86	19	constraints	constraint	NOUN
biomedich-119	86	20	(	(	PUNCT
biomedich-119	86	21	cadaver	cadaver	NOUN
biomedich-119	86	22	-	-	PUNCT
biomedich-119	86	23	based	base	VERB
biomedich-119	86	24	)	)	PUNCT
biomedich-119	86	25	and	and	CCONJ
biomedich-119	86	26	chronic	chronic	ADJ
biomedich-119	86	27	immunosuppression	immunosuppression	NOUN
biomedich-119	86	28	.	.	PUNCT
biomedich-119	87	1	important	important	ADJ
biomedich-119	87	2	progress	progress	NOUN
biomedich-119	87	3	has	have	AUX
biomedich-119	87	4	been	be	AUX
biomedich-119	87	5	made	make	VERB
biomedich-119	87	6	over	over	ADP
biomedich-119	87	7	the	the	DET
biomedich-119	87	8	past	past	ADJ
biomedich-119	87	9	decade	decade	NOUN
biomedich-119	87	10	in	in	ADP
biomedich-119	87	11	tackling	tackle	VERB
biomedich-119	87	12	these	these	DET
biomedich-119	87	13	obstacles	obstacle	NOUN
biomedich-119	87	14	to	to	ADP
biomedich-119	87	15	broad	broad	ADJ
biomedich-119	87	16	cell	cell	NOUN
biomedich-119	87	17	therapy	therapy	NOUN
biomedich-119	87	18	adoption	adoption	NOUN
biomedich-119	87	19	(	(	PUNCT
biomedich-119	87	20	latres	latre	NOUN
biomedich-119	87	21	et	et	PROPN
biomedich-119	87	22	al	al	PROPN
biomedich-119	87	23	.	.	PROPN
biomedich-119	87	24	,	,	PUNCT
biomedich-119	87	25	2019	2019	NUM
biomedich-119	87	26	)	)	PUNCT
biomedich-119	87	27	.	.	PUNCT
biomedich-119	88	1	the	the	DET
biomedich-119	88	2	possibility	possibility	NOUN
biomedich-119	88	3	that	that	SCONJ
biomedich-119	88	4	the	the	DET
biomedich-119	88	5	risk	risk	NOUN
biomedich-119	88	6	variants	variant	NOUN
biomedich-119	88	7	of	of	ADP
biomedich-119	88	8	bach2	bach2	NOUN
biomedich-119	88	9	and	and	CCONJ
biomedich-119	88	10	clec16a	clec16a	NOUN
biomedich-119	88	11	could	could	AUX
biomedich-119	88	12	contribute	contribute	VERB
biomedich-119	88	13	to	to	ADP
biomedich-119	88	14	the	the	DET
biomedich-119	88	15	development	development	NOUN
biomedich-119	88	16	of	of	ADP
biomedich-119	88	17	insulin	insulin	NOUN
biomedich-119	88	18	-	-	PUNCT
biomedich-119	88	19	triggered	trigger	VERB
biomedich-119	88	20	type	type	NOUN
biomedich-119	88	21	1	1	NUM
biomedich-119	88	22	diabetes	diabetes	NOUN
biomedich-119	88	23	can	can	AUX
biomedich-119	88	24	not	not	PART
biomedich-119	88	25	be	be	AUX
biomedich-119	88	26	excluded	exclude	VERB
biomedich-119	88	27	in	in	ADP
biomedich-119	88	28	addition	addition	NOUN
biomedich-119	88	29	to	to	ADP
biomedich-119	88	30	the	the	DET
biomedich-119	88	31	type	type	NOUN
biomedich-119	88	32	1	1	NUM
biomedich-119	88	33	diabetes	diabetes	NOUN
biomedich-119	88	34	high	high	ADJ
biomedich-119	88	35	-	-	PUNCT
biomedich-119	88	36	risk	risk	NOUN
biomedich-119	88	37	human	human	ADJ
biomedich-119	88	38	leukocyte	leukocyte	NOUN
biomedich-119	88	39	antigen	antigen	ADJ
biomedich-119	88	40	class	class	NOUN
biomedich-119	88	41	ii	ii	NOUN
biomedich-119	88	42	and	and	CCONJ
biomedich-119	88	43	the	the	DET
biomedich-119	88	44	class	class	NOUN
biomedich-119	88	45	i	i	PRON
biomedich-119	88	46	allele	allele	NOUN
biomedich-119	88	47	of	of	ADP
biomedich-119	88	48	the	the	DET
biomedich-119	88	49	insulin	insulin	NOUN
biomedich-119	88	50	gene	gene	NOUN
biomedich-119	88	51	variable	variable	ADJ
biomedich-119	88	52	number	number	NOUN
biomedich-119	88	53	tandem	tandem	NOUN
biomedich-119	88	54	repeat	repeat	NOUN
biomedich-119	88	55	genotype	genotype	NOUN
biomedich-119	88	56	(	(	PUNCT
biomedich-119	88	57	onuma	onuma	INTJ
biomedich-119	88	58	et	et	PROPN
biomedich-119	88	59	al	al	PROPN
biomedich-119	88	60	.	.	PROPN
biomedich-119	88	61	,	,	PUNCT
biomedich-119	88	62	2019	2019	NUM
biomedich-119	88	63	)	)	PUNCT
biomedich-119	88	64	.	.	PUNCT
biomedich-119	89	1	therapeutic	therapeutic	ADJ
biomedich-119	89	2	studies	study	NOUN
biomedich-119	89	3	assess	assess	VERB
biomedich-119	89	4	the	the	DET
biomedich-119	89	5	efficacy	efficacy	NOUN
biomedich-119	89	6	of	of	ADP
biomedich-119	89	7	antigenspecific	antigenspecific	ADJ
biomedich-119	89	8	and	and	CCONJ
biomedich-119	89	9	antigen	antigen	ADJ
biomedich-119	89	10	-	-	PUNCT
biomedich-119	89	11	nonspecific	nonspecific	ADJ
biomedich-119	89	12	immune	immune	ADJ
biomedich-119	89	13	therapies	therapy	NOUN
biomedich-119	89	14	,	,	PUNCT
biomedich-119	89	15	which	which	PRON
biomedich-119	89	16	also	also	ADV
biomedich-119	89	17	include	include	VERB
biomedich-119	89	18	reconstruction	reconstruction	NOUN
biomedich-119	89	19	of	of	ADP
biomedich-119	89	20	the	the	DET
biomedich-119	89	21	damaged	damage	VERB
biomedich-119	89	22	betacell	betacell	NOUN
biomedich-119	89	23	mass	mass	NOUN
biomedich-119	89	24	via	via	ADP
biomedich-119	89	25	islet	islet	NOUN
biomedich-119	89	26	transplantation	transplantation	NOUN
biomedich-119	89	27	,	,	PUNCT
biomedich-119	89	28	neogenesis	neogenesis	NOUN
biomedich-119	89	29	,	,	PUNCT
biomedich-119	89	30	and	and	CCONJ
biomedich-119	89	31	regeneration	regeneration	NOUN
biomedich-119	89	32	,	,	PUNCT
biomedich-119	89	33	and	and	CCONJ
biomedich-119	89	34	their	their	PRON
biomedich-119	89	35	combinations	combination	NOUN
biomedich-119	89	36	(	(	PUNCT
biomedich-119	89	37	van	van	PROPN
biomedich-119	89	38	et	et	PROPN
biomedich-119	89	39	al	al	PROPN
biomedich-119	89	40	.	.	PROPN
biomedich-119	89	41	,	,	PUNCT
biomedich-119	89	42	2011	2011	NUM
biomedich-119	89	43	)	)	PUNCT
biomedich-119	89	44	.	.	PUNCT
biomedich-119	90	1	cells	cell	NOUN
biomedich-119	90	2	that	that	PRON
biomedich-119	90	3	express	express	VERB
biomedich-119	90	4	insulin	insulin	NOUN
biomedich-119	90	5	and	and	CCONJ
biomedich-119	90	6	have	have	VERB
biomedich-119	90	7	molecular	molecular	ADJ
biomedich-119	90	8	characteristics	characteristic	NOUN
biomedich-119	90	9	that	that	PRON
biomedich-119	90	10	closely	closely	ADV
biomedich-119	90	11	resemble	resemble	VERB
biomedich-119	90	12	bona	bona	ADJ
biomedich-119	90	13	fide	fide	ADJ
biomedich-119	90	14	insulinsecreting	insulinsecreting	NOUN
biomedich-119	90	15	cells	cell	NOUN
biomedich-119	90	16	have	have	AUX
biomedich-119	90	17	been	be	AUX
biomedich-119	90	18	produced	produce	VERB
biomedich-119	90	19	by	by	ADP
biomedich-119	90	20	the	the	DET
biomedich-119	90	21	most	most	ADV
biomedich-119	90	22	effective	effective	ADJ
biomedich-119	90	23	protocols	protocol	NOUN
biomedich-119	90	24	to	to	ADP
biomedich-119	90	25	date	date	NOUN
biomedich-119	90	26	;	;	PUNCT
biomedich-119	90	27	however	however	ADV
biomedich-119	90	28	,	,	PUNCT
biomedich-119	90	29	these	these	DET
biomedich-119	90	30	cells	cell	NOUN
biomedich-119	90	31	are	be	AUX
biomedich-119	90	32	often	often	ADV
biomedich-119	90	33	nonresponsive	nonresponsive	ADJ
biomedich-119	90	34	to	to	ADP
biomedich-119	90	35	glucose	glucose	VERB
biomedich-119	90	36	,	,	PUNCT
biomedich-119	90	37	a	a	DET
biomedich-119	90	38	feature	feature	NOUN
biomedich-119	90	39	that	that	PRON
biomedich-119	90	40	should	should	AUX
biomedich-119	90	41	be	be	AUX
biomedich-119	90	42	addressed	address	VERB
biomedich-119	90	43	in	in	ADP
biomedich-119	90	44	future	future	ADJ
biomedich-119	90	45	protocols	protocol	NOUN
biomedich-119	90	46	(	(	PUNCT
biomedich-119	90	47	aguayo	aguayo	PROPN
biomedich-119	90	48	et	et	PROPN
biomedich-119	90	49	al	al	PROPN
biomedich-119	90	50	.	.	PROPN
biomedich-119	90	51	,	,	PUNCT
biomedich-119	90	52	2010	2010	NUM
biomedich-119	90	53	)	)	PUNCT
biomedich-119	90	54	.	.	PUNCT
biomedich-119	91	1	such	such	ADJ
biomedich-119	91	2	beneficial	beneficial	ADJ
biomedich-119	91	3	effects	effect	NOUN
biomedich-119	91	4	of	of	ADP
biomedich-119	91	5	leptin	leptin	NOUN
biomedich-119	91	6	are	be	AUX
biomedich-119	91	7	not	not	PART
biomedich-119	91	8	underpinned	underpin	VERB
biomedich-119	91	9	by	by	ADP
biomedich-119	91	10	pancreatic	pancreatic	ADJ
biomedich-119	91	11	β	β	NOUN
biomedich-119	91	12	-	-	NOUN
biomedich-119	91	13	cell	cell	NOUN
biomedich-119	91	14	regeneration	regeneration	NOUN
biomedich-119	91	15	,	,	PUNCT
biomedich-119	91	16	since	since	SCONJ
biomedich-119	91	17	circulating	circulate	VERB
biomedich-119	91	18	insulin	insulin	NOUN
biomedich-119	91	19	levels	level	NOUN
biomedich-119	91	20	were	be	AUX
biomedich-119	91	21	undetectable	undetectable	ADJ
biomedich-119	91	22	at	at	ADP
biomedich-119	91	23	basal	basal	NOUN
biomedich-119	91	24	and	and	CCONJ
biomedich-119	91	25	glucose	glucose	NOUN
biomedich-119	91	26	overload	overload	NOUN
biomedich-119	91	27	levels	level	NOUN
biomedich-119	91	28	(	(	PUNCT
biomedich-119	91	29	fujikawa	fujikawa	PROPN
biomedich-119	91	30	et	et	PROPN
biomedich-119	91	31	al	al	PROPN
biomedich-119	91	32	.	.	PROPN
biomedich-119	91	33	,	,	PUNCT
biomedich-119	91	34	2010	2010	NUM
biomedich-119	91	35	)	)	PUNCT
biomedich-119	91	36	.	.	PUNCT
biomedich-119	92	1	however	however	ADV
biomedich-119	92	2	,	,	PUNCT
biomedich-119	92	3	contrary	contrary	ADV
biomedich-119	92	4	to	to	ADP
biomedich-119	92	5	insulin	insulin	NOUN
biomedich-119	92	6	monotherapy	monotherapy	NOUN
biomedich-119	92	7	,	,	PUNCT
biomedich-119	92	8	leptin	leptin	NOUN
biomedich-119	92	9	reduces	reduce	VERB
biomedich-119	92	10	both	both	PRON
biomedich-119	92	11	lipogenic	lipogenic	ADJ
biomedich-119	92	12	and	and	CCONJ
biomedich-119	92	13	cholesterologenic	cholesterologenic	ADJ
biomedich-119	92	14	transcription	transcription	NOUN
biomedich-119	92	15	factors	factor	NOUN
biomedich-119	92	16	and	and	CCONJ
biomedich-119	92	17	enzymes	enzyme	NOUN
biomedich-119	92	18	,	,	PUNCT
biomedich-119	92	19	and	and	CCONJ
biomedich-119	92	20	reduces	reduce	VERB
biomedich-119	92	21	lipids	lipid	NOUN
biomedich-119	92	22	from	from	ADP
biomedich-119	92	23	plasma	plasma	NOUN
biomedich-119	92	24	and	and	CCONJ
biomedich-119	92	25	tissue	tissue	NOUN
biomedich-119	92	26	(	(	PUNCT
biomedich-119	92	27	wang	wang	PROPN
biomedich-119	92	28	et	et	PROPN
biomedich-119	92	29	al	al	PROPN
biomedich-119	92	30	.	.	PROPN
biomedich-119	92	31	,	,	PUNCT
biomedich-119	92	32	2010	2010	NUM
biomedich-119	92	33	)	)	PUNCT
biomedich-119	92	34	.	.	PUNCT
biomedich-119	93	1	60	60	NUM
biomedich-119	93	2	biology	biology	NOUN
biomedich-119	93	3	,	,	PUNCT
biomedich-119	93	4	medicine	medicine	NOUN
biomedich-119	93	5	,	,	PUNCT
biomedich-119	93	6	&	&	CCONJ
biomedich-119	93	7	natural	natural	ADJ
biomedich-119	93	8	product	product	NOUN
biomedich-119	93	9	chemistry	chemistry	NOUN
biomedich-119	93	10	9	9	NUM
biomedich-119	93	11	(	(	PUNCT
biomedich-119	93	12	2	2	NUM
biomedich-119	93	13	)	)	PUNCT
biomedich-119	93	14	,	,	PUNCT
biomedich-119	93	15	2020	2020	NUM
biomedich-119	93	16	:	:	PUNCT
biomedich-119	93	17	57	57	NUM
biomedich-119	93	18	-	-	SYM
biomedich-119	93	19	64	64	NUM
biomedich-119	93	20	prevent	prevent	NOUN
biomedich-119	93	21	of	of	ADP
biomedich-119	93	22	type	type	NOUN
biomedich-119	93	23	1	1	NUM
biomedich-119	93	24	of	of	ADP
biomedich-119	93	25	diabetes	diabetes	NOUN
biomedich-119	93	26	by	by	ADP
biomedich-119	93	27	gene	gene	NOUN
biomedich-119	93	28	therapy	therapy	NOUN
biomedich-119	93	29	since	since	SCONJ
biomedich-119	93	30	no	no	DET
biomedich-119	93	31	existing	exist	VERB
biomedich-119	93	32	targeted	target	VERB
biomedich-119	93	33	immunotherapies	immunotherapy	NOUN
biomedich-119	93	34	are	be	AUX
biomedich-119	93	35	currently	currently	ADV
biomedich-119	93	36	unable	unable	ADJ
biomedich-119	93	37	to	to	PART
biomedich-119	93	38	replace	replace	VERB
biomedich-119	93	39	the	the	DET
biomedich-119	93	40	normal	normal	ADJ
biomedich-119	93	41	insulin	insulin	NOUN
biomedich-119	93	42	delivery	delivery	NOUN
biomedich-119	93	43	,	,	PUNCT
biomedich-119	93	44	it	it	PRON
biomedich-119	93	45	is	be	AUX
biomedich-119	93	46	important	important	ADJ
biomedich-119	93	47	to	to	PART
biomedich-119	93	48	have	have	VERB
biomedich-119	93	49	a	a	DET
biomedich-119	93	50	deep	deep	ADJ
biomedich-119	93	51	understanding	understanding	NOUN
biomedich-119	93	52	of	of	ADP
biomedich-119	93	53	t1d	t1d	PROPN
biomedich-119	93	54	pathophysiology	pathophysiology	NOUN
biomedich-119	93	55	to	to	PART
biomedich-119	93	56	prevent	prevent	VERB
biomedich-119	93	57	t1d	t1d	PROPN
biomedich-119	93	58	development	development	NOUN
biomedich-119	93	59	(	(	PUNCT
biomedich-119	93	60	kaur	kaur	PROPN
biomedich-119	93	61	,	,	PUNCT
biomedich-119	93	62	2020	2020	NUM
biomedich-119	93	63	)	)	PUNCT
biomedich-119	93	64	.	.	PUNCT
biomedich-119	94	1	the	the	DET
biomedich-119	94	2	study	study	NOUN
biomedich-119	94	3	shows	show	VERB
biomedich-119	94	4	that	that	SCONJ
biomedich-119	94	5	aat	aat	ADJ
biomedich-119	94	6	gene	gene	NOUN
biomedich-119	94	7	therapy	therapy	NOUN
biomedich-119	94	8	decreases	decrease	VERB
biomedich-119	94	9	cell	cell	NOUN
biomedich-119	94	10	-	-	PUNCT
biomedich-119	94	11	mediated	mediate	VERB
biomedich-119	94	12	autoimmunity	autoimmunity	NOUN
biomedich-119	94	13	,	,	PUNCT
biomedich-119	94	14	changes	change	VERB
biomedich-119	94	15	the	the	DET
biomedich-119	94	16	repertoire	repertoire	NOUN
biomedich-119	94	17	of	of	ADP
biomedich-119	94	18	t	t	NOUN
biomedich-119	94	19	-	-	PUNCT
biomedich-119	94	20	cell	cell	NOUN
biomedich-119	94	21	receptors	receptor	NOUN
biomedich-119	94	22	and	and	CCONJ
biomedich-119	94	23	effectively	effectively	ADV
biomedich-119	94	24	prevents	prevent	VERB
biomedich-119	94	25	type	type	NOUN
biomedich-119	94	26	1	1	NUM
biomedich-119	94	27	diabetes	diabetes	NOUN
biomedich-119	94	28	in	in	ADP
biomedich-119	94	29	the	the	DET
biomedich-119	94	30	nod	nod	PROPN
biomedich-119	94	31	mouse	mouse	NOUN
biomedich-119	94	32	model	model	NOUN
biomedich-119	94	33	.	.	PUNCT
biomedich-119	95	1	these	these	DET
biomedich-119	95	2	findings	finding	NOUN
biomedich-119	95	3	strongly	strongly	ADV
biomedich-119	95	4	suggest	suggest	VERB
biomedich-119	95	5	that	that	SCONJ
biomedich-119	95	6	aat	aat	ADJ
biomedich-119	95	7	gene	gene	NOUN
biomedich-119	95	8	therapy	therapy	NOUN
biomedich-119	95	9	mediated	mediate	VERB
biomedich-119	95	10	by	by	ADP
biomedich-119	95	11	raav1	raav1	NOUN
biomedich-119	95	12	may	may	AUX
biomedich-119	95	13	be	be	AUX
biomedich-119	95	14	useful	useful	ADJ
biomedich-119	95	15	as	as	ADP
biomedich-119	95	16	a	a	DET
biomedich-119	95	17	novel	novel	ADJ
biomedich-119	95	18	approach	approach	NOUN
biomedich-119	95	19	to	to	ADP
biomedich-119	95	20	preventing	prevent	VERB
biomedich-119	95	21	type	type	NOUN
biomedich-119	95	22	1	1	NUM
biomedich-119	95	23	diabetes	diabetes	NOUN
biomedich-119	95	24	(	(	PUNCT
biomedich-119	95	25	lu	lu	NOUN
biomedich-119	95	26	et	et	PROPN
biomedich-119	95	27	al	al	PROPN
biomedich-119	95	28	.	.	PROPN
biomedich-119	95	29	,	,	PUNCT
biomedich-119	95	30	2006	2006	NUM
biomedich-119	95	31	)	)	PUNCT
biomedich-119	95	32	.	.	PUNCT
biomedich-119	96	1	the	the	DET
biomedich-119	96	2	data	datum	NOUN
biomedich-119	96	3	indicate	indicate	VERB
biomedich-119	96	4	that	that	SCONJ
biomedich-119	96	5	expression	expression	NOUN
biomedich-119	96	6	of	of	ADP
biomedich-119	96	7	defensive	defensive	ADJ
biomedich-119	96	8	mhc	mhc	PROPN
biomedich-119	96	9	class	class	PROPN
biomedich-119	96	10	ii	ii	PROPN
biomedich-119	96	11	alleles	allele	NOUN
biomedich-119	96	12	in	in	ADP
biomedich-119	96	13	bone	bone	NOUN
biomedich-119	96	14	marrow	marrow	NOUN
biomedich-119	96	15	-	-	PUNCT
biomedich-119	96	16	derived	derive	VERB
biomedich-119	96	17	cells	cell	NOUN
biomedich-119	96	18	provides	provide	VERB
biomedich-119	96	19	robust	robust	ADJ
biomedich-119	96	20	self	self	NOUN
biomedich-119	96	21	-	-	PUNCT
biomedich-119	96	22	tolerance	tolerance	NOUN
biomedich-119	96	23	to	to	PART
biomedich-119	96	24	islet	islet	VERB
biomedich-119	96	25	autoantigens	autoantigen	NOUN
biomedich-119	96	26	and	and	CCONJ
biomedich-119	96	27	is	be	AUX
biomedich-119	96	28	adequate	adequate	ADJ
biomedich-119	96	29	to	to	PART
biomedich-119	96	30	prevent	prevent	VERB
biomedich-119	96	31	recurrence	recurrence	NOUN
biomedich-119	96	32	of	of	ADP
biomedich-119	96	33	autoimmune	autoimmune	ADJ
biomedich-119	96	34	diabetes	diabetes	NOUN
biomedich-119	96	35	following	follow	VERB
biomedich-119	96	36	islet	islet	NOUN
biomedich-119	96	37	transplantation	transplantation	NOUN
biomedich-119	96	38	(	(	PUNCT
biomedich-119	96	39	tian	tian	PROPN
biomedich-119	96	40	et	et	PROPN
biomedich-119	96	41	al	al	PROPN
biomedich-119	96	42	.	.	PROPN
biomedich-119	96	43	,	,	PUNCT
biomedich-119	96	44	2007	2007	NUM
biomedich-119	96	45	)	)	PUNCT
biomedich-119	96	46	.	.	PUNCT
biomedich-119	97	1	dual	dual	ADJ
biomedich-119	97	2	activity	activity	NOUN
biomedich-119	97	3	of	of	ADP
biomedich-119	97	4	heparanase	heparanase	NOUN
biomedich-119	97	5	inhibitors	inhibitor	NOUN
biomedich-119	97	6	/	/	SYM
biomedich-119	97	7	hs	hs	PROPN
biomedich-119	97	8	replacers	replacer	NOUN
biomedich-119	97	9	as	as	ADP
biomedich-119	97	10	a	a	DET
biomedich-119	97	11	novel	novel	ADJ
biomedich-119	97	12	therapeutic	therapeutic	ADJ
biomedich-119	97	13	class	class	NOUN
biomedich-119	97	14	to	to	PART
biomedich-119	97	15	prevent	prevent	VERB
biomedich-119	97	16	t1d	t1d	NOUN
biomedich-119	97	17	progression	progression	NOUN
biomedich-119	97	18	and	and	CCONJ
biomedich-119	97	19	potentially	potentially	ADV
biomedich-119	97	20	to	to	PART
biomedich-119	97	21	mitigate	mitigate	VERB
biomedich-119	97	22	secondary	secondary	ADJ
biomedich-119	97	23	vascular	vascular	ADJ
biomedich-119	97	24	disease	disease	NOUN
biomedich-119	97	25	developed	develop	VERB
biomedich-119	97	26	with	with	ADP
biomedich-119	97	27	long	long	ADJ
biomedich-119	97	28	-	-	PUNCT
biomedich-119	97	29	term	term	NOUN
biomedich-119	97	30	t1d	t1d	PROPN
biomedich-119	97	31	(	(	PUNCT
biomedich-119	97	32	simeonovic	simeonovic	PROPN
biomedich-119	97	33	et	et	PROPN
biomedich-119	97	34	al	al	PROPN
biomedich-119	97	35	.	.	PROPN
biomedich-119	97	36	,	,	PUNCT
biomedich-119	97	37	2020	2020	NUM
biomedich-119	97	38	)	)	PUNCT
biomedich-119	97	39	.	.	PUNCT
biomedich-119	98	1	an	an	DET
biomedich-119	98	2	independent	independent	ADJ
biomedich-119	98	3	study	study	NOUN
biomedich-119	98	4	showed	show	VERB
biomedich-119	98	5	that	that	SCONJ
biomedich-119	98	6	the	the	DET
biomedich-119	98	7	optimal	optimal	ADJ
biomedich-119	98	8	rise	rise	NOUN
biomedich-119	98	9	of	of	ADP
biomedich-119	98	10	gcs	gcs	PROPN
biomedich-119	98	11	in	in	ADP
biomedich-119	98	12	beta	beta	NOUN
biomedich-119	98	13	-	-	PUNCT
biomedich-119	98	14	cells	cell	NOUN
biomedich-119	98	15	was	be	AUX
biomedich-119	98	16	a	a	DET
biomedich-119	98	17	compensatory	compensatory	ADJ
biomedich-119	98	18	mechanism	mechanism	NOUN
biomedich-119	98	19	that	that	PRON
biomedich-119	98	20	prevented	prevent	VERB
biomedich-119	98	21	high	high	ADJ
biomedich-119	98	22	-	-	PUNCT
biomedich-119	98	23	fat	fat	NOUN
biomedich-119	98	24	diet	diet	NOUN
biomedich-119	98	25	-	-	PUNCT
biomedich-119	98	26	induced	induce	VERB
biomedich-119	98	27	betacell	betacell	ADJ
biomedich-119	98	28	failure	failure	NOUN
biomedich-119	98	29	(	(	PUNCT
biomedich-119	98	30	cobo	cobo	NOUN
biomedich-119	98	31	et	et	PROPN
biomedich-119	98	32	al	al	PROPN
biomedich-119	98	33	.	.	PROPN
biomedich-119	98	34	,	,	PUNCT
biomedich-119	98	35	2020	2020	NUM
biomedich-119	98	36	)	)	PUNCT
biomedich-119	98	37	.	.	PUNCT
biomedich-119	99	1	the	the	DET
biomedich-119	99	2	role	role	NOUN
biomedich-119	99	3	of	of	ADP
biomedich-119	99	4	combination	combination	NOUN
biomedich-119	99	5	therapy	therapy	NOUN
biomedich-119	99	6	in	in	ADP
biomedich-119	99	7	the	the	DET
biomedich-119	99	8	prevention	prevention	NOUN
biomedich-119	99	9	of	of	ADP
biomedich-119	99	10	diabetic	diabetic	ADJ
biomedich-119	99	11	cardiomyopathy	cardiomyopathy	ADJ
biomedich-119	99	12	,	,	PUNCT
biomedich-119	99	13	without	without	ADP
biomedich-119	99	14	forgetting	forget	VERB
biomedich-119	99	15	the	the	DET
biomedich-119	99	16	major	major	ADJ
biomedich-119	99	17	contribution	contribution	NOUN
biomedich-119	99	18	of	of	ADP
biomedich-119	99	19	insulin	insulin	NOUN
biomedich-119	99	20	,	,	PUNCT
biomedich-119	99	21	the	the	DET
biomedich-119	99	22	preferred	prefer	VERB
biomedich-119	99	23	medication	medication	NOUN
biomedich-119	99	24	for	for	ADP
biomedich-119	99	25	the	the	DET
biomedich-119	99	26	treatment	treatment	NOUN
biomedich-119	99	27	of	of	ADP
biomedich-119	99	28	t1	t1	PROPN
biomedich-119	99	29	dm	dm	PROPN
biomedich-119	99	30	(	(	PUNCT
biomedich-119	99	31	cieluch	cieluch	ADV
biomedich-119	99	32	et	et	PROPN
biomedich-119	99	33	al	al	PROPN
biomedich-119	99	34	.	.	PROPN
biomedich-119	99	35	,	,	PUNCT
biomedich-119	99	36	2020	2020	NUM
biomedich-119	99	37	)	)	PUNCT
biomedich-119	99	38	.	.	PUNCT
biomedich-119	100	1	in	in	ADP
biomedich-119	100	2	several	several	ADJ
biomedich-119	100	3	chronic	chronic	ADJ
biomedich-119	100	4	diseases	disease	NOUN
biomedich-119	100	5	,	,	PUNCT
biomedich-119	100	6	including	include	VERB
biomedich-119	100	7	t1d	t1d	PROPN
biomedich-119	100	8	,	,	PUNCT
biomedich-119	100	9	a	a	DET
biomedich-119	100	10	large	large	ADJ
biomedich-119	100	11	number	number	NOUN
biomedich-119	100	12	of	of	ADP
biomedich-119	100	13	proinflammatory	proinflammatory	ADJ
biomedich-119	100	14	ligands	ligand	NOUN
biomedich-119	100	15	that	that	PRON
biomedich-119	100	16	can	can	AUX
biomedich-119	100	17	signal	signal	VERB
biomedich-119	100	18	via	via	ADP
biomedich-119	100	19	rage	rage	NOUN
biomedich-119	100	20	have	have	AUX
biomedich-119	100	21	been	be	AUX
biomedich-119	100	22	implicated	implicate	VERB
biomedich-119	100	23	.	.	PUNCT
biomedich-119	101	1	it	it	PRON
biomedich-119	101	2	is	be	AUX
biomedich-119	101	3	therefore	therefore	ADV
biomedich-119	101	4	unbelievable	unbelievable	ADJ
biomedich-119	101	5	that	that	SCONJ
biomedich-119	101	6	rage	rage	NOUN
biomedich-119	101	7	has	have	AUX
biomedich-119	101	8	become	become	VERB
biomedich-119	101	9	a	a	DET
biomedich-119	101	10	possible	possible	ADJ
biomedich-119	101	11	therapeutic	therapeutic	ADJ
biomedich-119	101	12	target	target	NOUN
biomedich-119	101	13	for	for	ADP
biomedich-119	101	14	disease	disease	NOUN
biomedich-119	101	15	treatment	treatment	NOUN
biomedich-119	101	16	and	and	CCONJ
biomedich-119	101	17	prevention	prevention	NOUN
biomedich-119	101	18	(	(	PUNCT
biomedich-119	101	19	le	le	X
biomedich-119	101	20	et	et	PROPN
biomedich-119	101	21	al	al	PROPN
biomedich-119	101	22	.	.	PROPN
biomedich-119	101	23	,	,	PUNCT
biomedich-119	101	24	2020	2020	NUM
biomedich-119	101	25	)	)	PUNCT
biomedich-119	101	26	.	.	PUNCT
biomedich-119	102	1	as	as	ADP
biomedich-119	102	2	an	an	DET
biomedich-119	102	3	antigen	antigen	NOUN
biomedich-119	102	4	-	-	PUNCT
biomedich-119	102	5	specific	specific	ADJ
biomedich-119	102	6	monotherapy	monotherapy	NOUN
biomedich-119	102	7	,	,	PUNCT
biomedich-119	102	8	adi-100	adi-100	NOUN
biomedich-119	102	9	is	be	AUX
biomedich-119	102	10	highly	highly	ADV
biomedich-119	102	11	e	e	SYM
biomedich-119	102	12	cacious	cacious	ADJ
biomedich-119	102	13	in	in	ADP
biomedich-119	102	14	reversing	reverse	VERB
biomedich-119	102	15	elevated	elevated	ADJ
biomedich-119	102	16	hyperglycemia	hyperglycemia	NOUN
biomedich-119	102	17	to	to	PART
biomedich-119	102	18	prevent	prevent	VERB
biomedich-119	102	19	diabetes	diabetes	NOUN
biomedich-119	102	20	,	,	PUNCT
biomedich-119	102	21	where	where	SCONJ
biomedich-119	102	22	a	a	DET
biomedich-119	102	23	promising	promising	ADJ
biomedich-119	102	24	feature	feature	NOUN
biomedich-119	102	25	of	of	ADP
biomedich-119	102	26	immune	immune	ADJ
biomedich-119	102	27	tolerance	tolerance	NOUN
biomedich-119	102	28	is	be	AUX
biomedich-119	102	29	the	the	DET
biomedich-119	102	30	increased	increase	VERB
biomedich-119	102	31	apoptosis	apoptosis	NOUN
biomedich-119	102	32	-	-	PUNCT
biomedich-119	102	33	inducing	induce	VERB
biomedich-119	102	34	bax	bax	NOUN
biomedich-119	102	35	content	content	NOUN
biomedich-119	102	36	(	(	PUNCT
biomedich-119	102	37	alleva	alleva	PROPN
biomedich-119	102	38	et	et	PROPN
biomedich-119	102	39	al	al	PROPN
biomedich-119	102	40	.	.	PROPN
biomedich-119	102	41	,	,	PUNCT
biomedich-119	102	42	2020	2020	NUM
biomedich-119	102	43	)	)	PUNCT
biomedich-119	102	44	.	.	PUNCT
biomedich-119	103	1	it	it	PRON
biomedich-119	103	2	has	have	AUX
biomedich-119	103	3	been	be	AUX
biomedich-119	103	4	shown	show	VERB
biomedich-119	103	5	that	that	SCONJ
biomedich-119	103	6	the	the	DET
biomedich-119	103	7	formulated	formulated	ADJ
biomedich-119	103	8	autoantigenic	autoantigenic	ADJ
biomedich-119	103	9	islet	islet	NOUN
biomedich-119	103	10	peptides	peptide	NOUN
biomedich-119	103	11	(	(	PUNCT
biomedich-119	103	12	gad65206	gad65206	NOUN
biomedich-119	103	13	-	-	PUNCT
biomedich-119	103	14	220	220	NUM
biomedich-119	103	15	,	,	PUNCT
biomedich-119	103	16	gad65536	gad65536	NOUN
biomedich-119	103	17	-	-	PUNCT
biomedich-119	103	18	550	550	NUM
biomedich-119	103	19	,	,	PUNCT
biomedich-119	103	20	insulin	insulin	NOUN
biomedich-119	103	21	b923	b923	PROPN
biomedich-119	103	22	,	,	PUNCT
biomedich-119	103	23	and	and	CCONJ
biomedich-119	103	24	c17	c17	NOUN
biomedich-119	103	25	-	-	PUNCT
biomedich-119	103	26	a1	a1	NOUN
biomedich-119	103	27	)	)	PUNCT
biomedich-119	103	28	used	use	VERB
biomedich-119	103	29	as	as	ADP
biomedich-119	103	30	a	a	DET
biomedich-119	103	31	tolerogenic	tolerogenic	ADJ
biomedich-119	103	32	vaccine	vaccine	NOUN
biomedich-119	103	33	prevented	prevent	VERB
biomedich-119	103	34	t1d	t1d	PROPN
biomedich-119	103	35	from	from	ADP
biomedich-119	103	36	developing	develop	VERB
biomedich-119	103	37	in	in	ADP
biomedich-119	103	38	prediabetic	prediabetic	ADJ
biomedich-119	103	39	nod	nod	NOUN
biomedich-119	103	40	mice	mouse	NOUN
biomedich-119	103	41	(	(	PUNCT
biomedich-119	103	42	zhou	zhou	X
biomedich-119	103	43	et	et	PROPN
biomedich-119	103	44	al	al	PROPN
biomedich-119	103	45	.	.	PROPN
biomedich-119	103	46	,	,	PUNCT
biomedich-119	103	47	2020	2020	NUM
biomedich-119	103	48	)	)	PUNCT
biomedich-119	103	49	.	.	PUNCT
biomedich-119	104	1	the	the	DET
biomedich-119	104	2	coxsackievirus	coxsackievirus	PROPN
biomedich-119	104	3	b	b	PROPN
biomedich-119	104	4	association	association	NOUN
biomedich-119	104	5	with	with	ADP
biomedich-119	104	6	the	the	DET
biomedich-119	104	7	onset	onset	NOUN
biomedich-119	104	8	of	of	ADP
biomedich-119	104	9	t1	t1	PROPN
biomedich-119	104	10	dm	dm	PROPN
biomedich-119	104	11	has	have	AUX
biomedich-119	104	12	been	be	AUX
biomedich-119	104	13	observed	observe	VERB
biomedich-119	104	14	.	.	PUNCT
biomedich-119	105	1	accurate	accurate	ADJ
biomedich-119	105	2	trigger	trigger	NOUN
biomedich-119	105	3	detection	detection	NOUN
biomedich-119	105	4	will	will	AUX
biomedich-119	105	5	contribute	contribute	VERB
biomedich-119	105	6	to	to	ADP
biomedich-119	105	7	the	the	DET
biomedich-119	105	8	creation	creation	NOUN
biomedich-119	105	9	of	of	ADP
biomedich-119	105	10	suitable	suitable	ADJ
biomedich-119	105	11	preventive	preventive	ADJ
biomedich-119	105	12	steps	step	NOUN
biomedich-119	105	13	.	.	PUNCT
biomedich-119	106	1	it	it	PRON
biomedich-119	106	2	can	can	AUX
biomedich-119	106	3	become	become	VERB
biomedich-119	106	4	a	a	DET
biomedich-119	106	5	foundation	foundation	NOUN
biomedich-119	106	6	for	for	ADP
biomedich-119	106	7	advanced	advanced	ADJ
biomedich-119	106	8	clinical	clinical	ADJ
biomedich-119	106	9	studies	study	NOUN
biomedich-119	106	10	to	to	PART
biomedich-119	106	11	prevent	prevent	VERB
biomedich-119	106	12	t1	t1	PROPN
biomedich-119	106	13	dm	dm	PROPN
biomedich-119	106	14	(	(	PUNCT
biomedich-119	106	15	desai	desai	PROPN
biomedich-119	106	16	et	et	PROPN
biomedich-119	106	17	al	al	PROPN
biomedich-119	106	18	.	.	PROPN
biomedich-119	106	19	,	,	PUNCT
biomedich-119	106	20	2020	2020	NUM
biomedich-119	106	21	)	)	PUNCT
biomedich-119	106	22	.	.	PUNCT
biomedich-119	107	1	recognizing	recognize	VERB
biomedich-119	107	2	that	that	SCONJ
biomedich-119	107	3	t1d	t1d	PROPN
biomedich-119	107	4	is	be	AUX
biomedich-119	107	5	primarily	primarily	ADV
biomedich-119	107	6	an	an	DET
biomedich-119	107	7	autoimmune	autoimmune	ADJ
biomedich-119	107	8	betacell	betacell	NOUN
biomedich-119	107	9	disorder	disorder	NOUN
biomedich-119	107	10	that	that	SCONJ
biomedich-119	107	11	only	only	ADV
biomedich-119	107	12	in	in	ADP
biomedich-119	107	13	its	its	PRON
biomedich-119	107	14	final	final	ADJ
biomedich-119	107	15	stage	stage	NOUN
biomedich-119	107	16	progresses	progress	VERB
biomedich-119	107	17	to	to	ADP
biomedich-119	107	18	a	a	DET
biomedich-119	107	19	metabolic	metabolic	NOUN
biomedich-119	107	20	syndrome	syndrome	NOUN
biomedich-119	107	21	will	will	AUX
biomedich-119	107	22	expand	expand	VERB
biomedich-119	107	23	therapeutic	therapeutic	ADJ
biomedich-119	107	24	options	option	NOUN
biomedich-119	107	25	for	for	ADP
biomedich-119	107	26	earlier	early	ADJ
biomedich-119	107	27	intervention	intervention	NOUN
biomedich-119	107	28	and	and	CCONJ
biomedich-119	107	29	improve	improve	VERB
biomedich-119	107	30	the	the	DET
biomedich-119	107	31	prospects	prospect	NOUN
biomedich-119	107	32	for	for	ADP
biomedich-119	107	33	prevention	prevention	NOUN
biomedich-119	107	34	(	(	PUNCT
biomedich-119	107	35	desai	desai	PROPN
biomedich-119	107	36	n	n	PROPN
biomedich-119	107	37	et	et	PROPN
biomedich-119	107	38	al	al	PROPN
biomedich-119	107	39	.	.	PROPN
biomedich-119	107	40	,	,	PUNCT
biomedich-119	107	41	2020	2020	NUM
biomedich-119	107	42	)	)	PUNCT
biomedich-119	107	43	.	.	PUNCT
biomedich-119	108	1	gene	gene	NOUN
biomedich-119	108	2	expression	expression	NOUN
biomedich-119	108	3	with	with	ADP
biomedich-119	108	4	immuno	immuno	ADJ
biomedich-119	108	5	-	-	ADJ
biomedich-119	108	6	regulatory	regulatory	ADJ
biomedich-119	108	7	capacity	capacity	NOUN
biomedich-119	108	8	may	may	AUX
biomedich-119	108	9	potentially	potentially	ADV
biomedich-119	108	10	decrease	decrease	VERB
biomedich-119	108	11	allograft	allograft	NOUN
biomedich-119	108	12	rejection	rejection	NOUN
biomedich-119	108	13	.	.	PUNCT
biomedich-119	109	1	recent	recent	ADJ
biomedich-119	109	2	studies	study	NOUN
biomedich-119	109	3	have	have	AUX
biomedich-119	109	4	shown	show	VERB
biomedich-119	109	5	that	that	DET
biomedich-119	109	6	viral	viral	ADJ
biomedich-119	109	7	interleukin	interleukin	NOUN
biomedich-119	109	8	(	(	PUNCT
biomedich-119	109	9	il)-10	il)-10	PROPN
biomedich-119	109	10	can	can	AUX
biomedich-119	109	11	decrease	decrease	VERB
biomedich-119	109	12	immune	immune	ADJ
biomedich-119	109	13	response	response	NOUN
biomedich-119	109	14	during	during	ADP
biomedich-119	109	15	allotransplantation	allotransplantation	NOUN
biomedich-119	109	16	and	and	CCONJ
biomedich-119	109	17	is	be	AUX
biomedich-119	109	18	one	one	NUM
biomedich-119	109	19	of	of	ADP
biomedich-119	109	20	the	the	DET
biomedich-119	109	21	most	most	ADV
biomedich-119	109	22	promising	promising	ADJ
biomedich-119	109	23	methods	method	NOUN
biomedich-119	109	24	for	for	ADP
biomedich-119	109	25	preventing	prevent	VERB
biomedich-119	109	26	rejection	rejection	NOUN
biomedich-119	109	27	(	(	PUNCT
biomedich-119	109	28	jeong	jeong	PROPN
biomedich-119	109	29	et	et	PROPN
biomedich-119	109	30	al	al	PROPN
biomedich-119	109	31	.	.	PROPN
biomedich-119	109	32	,	,	PUNCT
biomedich-119	109	33	2020	2020	NUM
biomedich-119	109	34	)	)	PUNCT
biomedich-119	109	35	.	.	PUNCT
biomedich-119	110	1	vectors	vector	NOUN
biomedich-119	110	2	for	for	ADP
biomedich-119	110	3	gene	gene	NOUN
biomedich-119	110	4	therapy	therapy	NOUN
biomedich-119	110	5	in	in	ADP
biomedich-119	110	6	diabetic	diabetic	ADJ
biomedich-119	110	7	virus	virus	NOUN
biomedich-119	110	8	vectors	vector	NOUN
biomedich-119	110	9	were	be	AUX
biomedich-119	110	10	used	use	VERB
biomedich-119	110	11	as	as	ADP
biomedich-119	110	12	gene	gene	NOUN
biomedich-119	110	13	transfer	transfer	NOUN
biomedich-119	110	14	vehicles	vehicle	NOUN
biomedich-119	110	15	for	for	ADP
biomedich-119	110	16	various	various	ADJ
biomedich-119	110	17	applications	application	NOUN
biomedich-119	110	18	in	in	ADP
biomedich-119	110	19	preclinical	preclinical	ADJ
biomedich-119	110	20	and	and	CCONJ
biomedich-119	110	21	clinical	clinical	ADJ
biomedich-119	110	22	gene	gene	NOUN
biomedich-119	110	23	therapy	therapy	NOUN
biomedich-119	110	24	and	and	CCONJ
biomedich-119	110	25	with	with	ADP
biomedich-119	110	26	the	the	DET
biomedich-119	110	27	approval	approval	NOUN
biomedich-119	110	28	of	of	ADP
biomedich-119	110	29	glybera	glybera	NOUN
biomedich-119	110	30	(	(	PUNCT
biomedich-119	110	31	alipogene	alipogene	NOUN
biomedich-119	110	32	tiparvovec	tiparvovec	PROPN
biomedich-119	110	33	)	)	PUNCT
biomedich-119	110	34	as	as	ADP
biomedich-119	110	35	the	the	DET
biomedich-119	110	36	first	first	ADJ
biomedich-119	110	37	gene	gene	NOUN
biomedich-119	110	38	therapy	therapy	NOUN
biomedich-119	110	39	product	product	NOUN
biomedich-119	110	40	as	as	ADP
biomedich-119	110	41	standard	standard	ADJ
biomedich-119	110	42	medical	medical	ADJ
biomedich-119	110	43	treatment	treatment	NOUN
biomedich-119	110	44	(	(	PUNCT
biomedich-119	110	45	goins	goin	NOUN
biomedich-119	110	46	et	et	NOUN
biomedich-119	110	47	al	al	PROPN
biomedich-119	110	48	.	.	PROPN
biomedich-119	110	49	,	,	PUNCT
biomedich-119	110	50	2020	2020	NUM
biomedich-119	110	51	)	)	PUNCT
biomedich-119	110	52	.	.	PUNCT
biomedich-119	111	1	the	the	DET
biomedich-119	111	2	use	use	NOUN
biomedich-119	111	3	of	of	ADP
biomedich-119	111	4	viruses	virus	NOUN
biomedich-119	111	5	as	as	ADP
biomedich-119	111	6	carriers	carrier	NOUN
biomedich-119	111	7	of	of	ADP
biomedich-119	111	8	genetic	genetic	ADJ
biomedich-119	111	9	products	product	NOUN
biomedich-119	111	10	requires	require	VERB
biomedich-119	111	11	a	a	DET
biomedich-119	111	12	detailed	detailed	ADJ
biomedich-119	111	13	and	and	CCONJ
biomedich-119	111	14	thorough	thorough	ADJ
biomedich-119	111	15	understanding	understanding	NOUN
biomedich-119	111	16	of	of	ADP
biomedich-119	111	17	viral	viral	ADJ
biomedich-119	111	18	vectors	vector	NOUN
biomedich-119	111	19	from	from	ADP
biomedich-119	111	20	viral	viral	ADJ
biomedich-119	111	21	preparation	preparation	NOUN
biomedich-119	111	22	to	to	ADP
biomedich-119	111	23	clinical	clinical	ADJ
biomedich-119	111	24	use	use	NOUN
biomedich-119	111	25	(	(	PUNCT
biomedich-119	111	26	afzal	afzal	PROPN
biomedich-119	111	27	et	et	PROPN
biomedich-119	111	28	al	al	PROPN
biomedich-119	111	29	.	.	PROPN
biomedich-119	111	30	,	,	PUNCT
biomedich-119	111	31	2020	2020	NUM
biomedich-119	111	32	)	)	PUNCT
biomedich-119	111	33	.	.	PUNCT
biomedich-119	112	1	adenoviral	adenoviral	ADJ
biomedich-119	112	2	vectors	vector	NOUN
biomedich-119	112	3	as	as	ADP
biomedich-119	112	4	one	one	NUM
biomedich-119	112	5	of	of	ADP
biomedich-119	112	6	the	the	DET
biomedich-119	112	7	most	most	ADV
biomedich-119	112	8	common	common	ADJ
biomedich-119	112	9	groups	group	NOUN
biomedich-119	112	10	used	use	VERB
biomedich-119	112	11	in	in	ADP
biomedich-119	112	12	gene	gene	NOUN
biomedich-119	112	13	therapy	therapy	NOUN
biomedich-119	112	14	have	have	VERB
biomedich-119	112	15	a	a	DET
biomedich-119	112	16	high	high	ADJ
biomedich-119	112	17	human	human	ADJ
biomedich-119	112	18	capacity	capacity	NOUN
biomedich-119	112	19	.	.	PUNCT
biomedich-119	113	1	they	they	PRON
biomedich-119	113	2	're	be	AUX
biomedich-119	113	3	not	not	PART
biomedich-119	113	4	actually	actually	ADV
biomedich-119	113	5	integrated	integrate	VERB
biomedich-119	113	6	into	into	ADP
biomedich-119	113	7	the	the	DET
biomedich-119	113	8	host	host	NOUN
biomedich-119	113	9	genome	genome	NOUN
biomedich-119	113	10	(	(	PUNCT
biomedich-119	113	11	arjmand	arjmand	PROPN
biomedich-119	113	12	et	et	PROPN
biomedich-119	113	13	al	al	PROPN
biomedich-119	113	14	.	.	PROPN
biomedich-119	113	15	,	,	PUNCT
biomedich-119	113	16	2020	2020	NUM
biomedich-119	113	17	)	)	PUNCT
biomedich-119	113	18	.	.	PUNCT
biomedich-119	114	1	in	in	ADP
biomedich-119	114	2	a	a	DET
biomedich-119	114	3	cerebellar	cerebellar	ADJ
biomedich-119	114	4	granule	granule	NOUN
biomedich-119	114	5	cell	cell	NOUN
biomedich-119	114	6	culture	culture	NOUN
biomedich-119	114	7	(	(	PUNCT
biomedich-119	114	8	cgc	cgc	PROPN
biomedich-119	114	9	)	)	PUNCT
biomedich-119	114	10	,	,	PUNCT
biomedich-119	114	11	treatment	treatment	NOUN
biomedich-119	114	12	with	with	ADP
biomedich-119	114	13	gad	gad	PROPN
biomedich-119	114	14	cdna	cdna	PROPN
biomedich-119	114	15	-	-	PUNCT
biomedich-119	114	16	containing	contain	VERB
biomedich-119	114	17	hsv	hsv	NOUN
biomedich-119	114	18	vectors	vector	NOUN
biomedich-119	114	19	increases	increase	VERB
biomedich-119	114	20	gad65	gad65	NOUN
biomedich-119	114	21	and	and	CCONJ
biomedich-119	114	22	gad67	gad67	NOUN
biomedich-119	114	23	expression	expression	NOUN
biomedich-119	114	24	and	and	CCONJ
biomedich-119	114	25	gaba	gaba	NOUN
biomedich-119	114	26	release	release	NOUN
biomedich-119	114	27	evoked	evoke	VERB
biomedich-119	114	28	by	by	ADP
biomedich-119	114	29	stimulation	stimulation	NOUN
biomedich-119	114	30	(	(	PUNCT
biomedich-119	114	31	kanao	kanao	PROPN
biomedich-119	114	32	et	et	PROPN
biomedich-119	114	33	al	al	PROPN
biomedich-119	114	34	.	.	PROPN
biomedich-119	114	35	,	,	PUNCT
biomedich-119	114	36	2020	2020	NUM
biomedich-119	114	37	)	)	PUNCT
biomedich-119	114	38	.	.	PUNCT
biomedich-119	115	1	the	the	DET
biomedich-119	115	2	definition	definition	NOUN
biomedich-119	115	3	of	of	ADP
biomedich-119	115	4	ad	ad	NOUN
biomedich-119	115	5	,	,	PUNCT
biomedich-119	115	6	aav	aav	NOUN
biomedich-119	115	7	and	and	CCONJ
biomedich-119	115	8	lv	lv	PROPN
biomedich-119	115	9	(	(	PUNCT
biomedich-119	115	10	shirley	shirley	PROPN
biomedich-119	115	11	et	et	PROPN
biomedich-119	115	12	al	al	PROPN
biomedich-119	115	13	.	.	PROPN
biomedich-119	115	14	,	,	PUNCT
biomedich-119	115	15	2020	2020	NUM
biomedich-119	115	16	)	)	PUNCT
biomedich-119	115	17	is	be	AUX
biomedich-119	115	18	given	give	VERB
biomedich-119	115	19	on	on	ADP
biomedich-119	115	20	the	the	DET
biomedich-119	115	21	other	other	ADJ
biomedich-119	115	22	hand	hand	NOUN
biomedich-119	115	23	to	to	PART
biomedich-119	115	24	competent	competent	VERB
biomedich-119	115	25	(	(	PUNCT
biomedich-119	115	26	rc	rc	NOUN
biomedich-119	115	27	)	)	PUNCT
biomedich-119	115	28	viral	viral	ADJ
biomedich-119	115	29	vectors	vector	NOUN
biomedich-119	115	30	(	(	PUNCT
biomedich-119	115	31	de	de	X
biomedich-119	115	32	et	et	PROPN
biomedich-119	115	33	al	al	PROPN
biomedich-119	115	34	.	.	PROPN
biomedich-119	115	35	,	,	PUNCT
biomedich-119	115	36	2020	2020	NUM
biomedich-119	115	37	)	)	PUNCT
biomedich-119	115	38	.	.	PUNCT
biomedich-119	116	1	the	the	DET
biomedich-119	116	2	advantage	advantage	NOUN
biomedich-119	116	3	of	of	ADP
biomedich-119	116	4	adenoviral	adenoviral	ADJ
biomedich-119	116	5	vectors	vector	NOUN
biomedich-119	116	6	over	over	ADP
biomedich-119	116	7	retroviral	retroviral	ADJ
biomedich-119	116	8	vectors	vector	NOUN
biomedich-119	116	9	is	be	AUX
biomedich-119	116	10	that	that	SCONJ
biomedich-119	116	11	they	they	PRON
biomedich-119	116	12	can	can	AUX
biomedich-119	116	13	transduce	transduce	VERB
biomedich-119	116	14	both	both	CCONJ
biomedich-119	116	15	dividing	dividing	NOUN
biomedich-119	116	16	and	and	CCONJ
biomedich-119	116	17	non	non	ADJ
biomedich-119	116	18	-	-	ADJ
biomedich-119	116	19	dividing	dividing	ADJ
biomedich-119	116	20	cells	cell	NOUN
biomedich-119	116	21	and	and	CCONJ
biomedich-119	116	22	can	can	AUX
biomedich-119	116	23	be	be	AUX
biomedich-119	116	24	prepared	prepare	VERB
biomedich-119	116	25	in	in	ADP
biomedich-119	116	26	high	high	ADJ
biomedich-119	116	27	titers	titer	NOUN
biomedich-119	116	28	.	.	PUNCT
biomedich-119	117	1	adenoviruses	adenovirus	NOUN
biomedich-119	117	2	can	can	AUX
biomedich-119	117	3	infect	infect	VERB
biomedich-119	117	4	insulin	insulin	NOUN
biomedich-119	117	5	-	-	PUNCT
biomedich-119	117	6	secreting	secrete	VERB
biomedich-119	117	7	cells	cell	NOUN
biomedich-119	117	8	,	,	PUNCT
biomedich-119	117	9	and	and	CCONJ
biomedich-119	117	10	it	it	PRON
biomedich-119	117	11	has	have	AUX
biomedich-119	117	12	been	be	AUX
biomedich-119	117	13	shown	show	VERB
biomedich-119	117	14	that	that	SCONJ
biomedich-119	117	15	they	they	PRON
biomedich-119	117	16	can	can	AUX
biomedich-119	117	17	transduce	transduce	VERB
biomedich-119	117	18	rodent	rodent	ADJ
biomedich-119	117	19	islets	islet	NOUN
biomedich-119	117	20	(	(	PUNCT
biomedich-119	117	21	borkar	borkar	NOUN
biomedich-119	117	22	et	et	PROPN
biomedich-119	117	23	al	al	PROPN
biomedich-119	117	24	.	.	PROPN
biomedich-119	117	25	,	,	PUNCT
biomedich-119	117	26	2020	2020	NUM
biomedich-119	117	27	)	)	PUNCT
biomedich-119	117	28	.	.	PUNCT
biomedich-119	118	1	co	co	NOUN
biomedich-119	118	2	-	-	NOUN
biomedich-119	118	3	precipitation	precipitation	NOUN
biomedich-119	118	4	of	of	ADP
biomedich-119	118	5	calcium	calcium	NOUN
biomedich-119	118	6	phosphate	phosphate	NOUN
biomedich-119	118	7	is	be	AUX
biomedich-119	118	8	a	a	DET
biomedich-119	118	9	simple	simple	ADJ
biomedich-119	118	10	and	and	CCONJ
biomedich-119	118	11	cheap	cheap	ADJ
biomedich-119	118	12	method	method	NOUN
biomedich-119	118	13	for	for	ADP
biomedich-119	118	14	the	the	DET
biomedich-119	118	15	genetically	genetically	ADV
biomedich-119	118	16	modified	modify	VERB
biomedich-119	118	17	pancreatic	pancreatic	ADJ
biomedich-119	118	18	cells	cell	NOUN
biomedich-119	118	19	being	be	AUX
biomedich-119	118	20	non	non	ADJ
biomedich-119	118	21	-	-	ADJ
biomedich-119	118	22	viral	viral	ADJ
biomedich-119	118	23	vectors	vector	NOUN
biomedich-119	118	24	(	(	PUNCT
biomedich-119	118	25	wong	wong	PROPN
biomedich-119	118	26	et	et	PROPN
biomedich-119	118	27	al	al	PROPN
biomedich-119	118	28	.	.	PROPN
biomedich-119	118	29	,	,	PUNCT
biomedich-119	118	30	2010	2010	NUM
biomedich-119	118	31	)	)	PUNCT
biomedich-119	118	32	.	.	PUNCT
biomedich-119	119	1	nearly	nearly	ADV
biomedich-119	119	2	all	all	PRON
biomedich-119	119	3	of	of	ADP
biomedich-119	119	4	the	the	DET
biomedich-119	119	5	non	non	ADJ
biomedich-119	119	6	-	-	ADJ
biomedich-119	119	7	viral	viral	ADJ
biomedich-119	119	8	vectors	vector	NOUN
biomedich-119	119	9	used	use	VERB
biomedich-119	119	10	to	to	ADP
biomedich-119	119	11	date	date	NOUN
biomedich-119	119	12	are	be	AUX
biomedich-119	119	13	plasmids	plasmid	NOUN
biomedich-119	119	14	of	of	ADP
biomedich-119	119	15	expression	expression	NOUN
biomedich-119	119	16	that	that	PRON
biomedich-119	119	17	were	be	AUX
biomedich-119	119	18	engineered	engineer	VERB
biomedich-119	119	19	for	for	ADP
biomedich-119	119	20	high	high	ADJ
biomedich-119	119	21	expression	expression	NOUN
biomedich-119	119	22	when	when	SCONJ
biomedich-119	119	23	transmitted	transmit	VERB
biomedich-119	119	24	to	to	ADP
biomedich-119	119	25	striated	striated	ADJ
biomedich-119	119	26	muscle	muscle	NOUN
biomedich-119	119	27	or	or	CCONJ
biomedich-119	119	28	other	other	ADJ
biomedich-119	119	29	cells	cell	NOUN
biomedich-119	119	30	(	(	PUNCT
biomedich-119	119	31	prud	prud	NOUN
biomedich-119	119	32	et	et	NOUN
biomedich-119	119	33	al	al	PROPN
biomedich-119	119	34	.	.	PROPN
biomedich-119	119	35	,	,	PUNCT
biomedich-119	119	36	2007	2007	NUM
biomedich-119	119	37	)	)	PUNCT
biomedich-119	119	38	.	.	PUNCT
biomedich-119	120	1	non	non	ADJ
biomedich-119	120	2	-	-	ADJ
biomedich-119	120	3	viral	viral	ADJ
biomedich-119	120	4	hvj	hvj	ADJ
biomedich-119	120	5	liposomemediated	liposomemediate	VERB
biomedich-119	120	6	human	human	PROPN
biomedich-119	120	7	hgf	hgf	NOUN
biomedich-119	120	8	gene	gene	NOUN
biomedich-119	120	9	transfer	transfer	NOUN
biomedich-119	120	10	has	have	VERB
biomedich-119	120	11	potential	potential	NOUN
biomedich-119	120	12	for	for	ADP
biomedich-119	120	13	safe	safe	ADJ
biomedich-119	120	14	and	and	CCONJ
biomedich-119	120	15	successful	successful	ADJ
biomedich-119	120	16	diabetic	diabetic	ADJ
biomedich-119	120	17	sensorimotor	sensorimotor	NOUN
biomedich-119	120	18	neuropathy	neuropathy	ADJ
biomedich-119	120	19	treatment	treatment	NOUN
biomedich-119	120	20	(	(	PUNCT
biomedich-119	120	21	kato	kato	PROPN
biomedich-119	120	22	et	et	PROPN
biomedich-119	120	23	al	al	PROPN
biomedich-119	120	24	.	.	PROPN
biomedich-119	120	25	,	,	PUNCT
biomedich-119	120	26	2005	2005	NUM
biomedich-119	120	27	)	)	PUNCT
biomedich-119	120	28	.	.	PUNCT
biomedich-119	121	1	future	future	ADJ
biomedich-119	121	2	gene	gene	NOUN
biomedich-119	121	3	therapy	therapy	NOUN
biomedich-119	121	4	in	in	ADP
biomedich-119	121	5	diabetes	diabetes	NOUN
biomedich-119	121	6	:	:	PUNCT
biomedich-119	121	7	in	in	ADP
biomedich-119	121	8	the	the	DET
biomedich-119	121	9	future	future	NOUN
biomedich-119	121	10	,	,	PUNCT
biomedich-119	121	11	therapeutic	therapeutic	ADJ
biomedich-119	121	12	strategies	strategy	NOUN
biomedich-119	121	13	should	should	AUX
biomedich-119	121	14	be	be	AUX
biomedich-119	121	15	personalized	personalize	VERB
biomedich-119	121	16	,	,	PUNCT
biomedich-119	121	17	given	give	VERB
biomedich-119	121	18	the	the	DET
biomedich-119	121	19	high	high	ADJ
biomedich-119	121	20	variance	variance	NOUN
biomedich-119	121	21	in	in	ADP
biomedich-119	121	22	genetics	genetic	NOUN
biomedich-119	121	23	and	and	CCONJ
biomedich-119	121	24	islet	islet	NOUN
biomedich-119	121	25	autoimmunity	autoimmunity	NOUN
biomedich-119	121	26	among	among	ADP
biomedich-119	121	27	patients	patient	NOUN
biomedich-119	121	28	(	(	PUNCT
biomedich-119	121	29	liu	liu	PROPN
biomedich-119	121	30	et	et	PROPN
biomedich-119	121	31	al	al	PROPN
biomedich-119	121	32	.	.	PROPN
biomedich-119	121	33	,	,	PUNCT
biomedich-119	121	34	2020	2020	NUM
biomedich-119	121	35	)	)	PUNCT
biomedich-119	121	36	.	.	PUNCT
biomedich-119	122	1	the	the	DET
biomedich-119	122	2	recent	recent	ADJ
biomedich-119	122	3	increase	increase	NOUN
biomedich-119	122	4	in	in	ADP
biomedich-119	122	5	global	global	ADJ
biomedich-119	122	6	stem	stem	NOUN
biomedich-119	122	7	cell	cell	NOUN
biomedich-119	122	8	research	research	NOUN
biomedich-119	122	9	funding	funding	NOUN
biomedich-119	122	10	is	be	AUX
biomedich-119	122	11	largely	largely	ADV
biomedich-119	122	12	based	base	VERB
biomedich-119	122	13	on	on	ADP
biomedich-119	122	14	the	the	DET
biomedich-119	122	15	promise	promise	NOUN
biomedich-119	122	16	to	to	PART
biomedich-119	122	17	translate	translate	VERB
biomedich-119	122	18	scientific	scientific	ADJ
biomedich-119	122	19	understanding	understanding	NOUN
biomedich-119	122	20	of	of	ADP
biomedich-119	122	21	stem	stem	NOUN
biomedich-119	122	22	cells	cell	NOUN
biomedich-119	122	23	into	into	ADP
biomedich-119	122	24	regenerative	regenerative	ADJ
biomedich-119	122	25	medicine	medicine	NOUN
biomedich-119	122	26	(	(	PUNCT
biomedich-119	122	27	wainwright	wainwright	NOUN
biomedich-119	122	28	et	et	PROPN
biomedich-119	122	29	al	al	PROPN
biomedich-119	122	30	.	.	PROPN
biomedich-119	122	31	,	,	PUNCT
biomedich-119	122	32	2006	2006	NUM
biomedich-119	122	33	)	)	PUNCT
biomedich-119	122	34	.	.	PUNCT
biomedich-119	123	1	as	as	SCONJ
biomedich-119	123	2	the	the	DET
biomedich-119	123	3	approaches	approach	NOUN
biomedich-119	123	4	to	to	ADP
biomedich-119	123	5	immunotherapy	immunotherapy	NOUN
biomedich-119	123	6	have	have	AUX
biomedich-119	123	7	remained	remain	VERB
biomedich-119	123	8	unsuccessful	unsuccessful	ADJ
biomedich-119	123	9	,	,	PUNCT
biomedich-119	123	10	transplantation	transplantation	NOUN
biomedich-119	123	11	of	of	ADP
biomedich-119	123	12	donor	donor	NOUN
biomedich-119	123	13	-	-	PUNCT
biomedich-119	123	14	derived	derive	VERB
biomedich-119	123	15	pancreas	pancrea	NOUN
biomedich-119	123	16	or	or	CCONJ
biomedich-119	123	17	islets	islet	NOUN
biomedich-119	123	18	is	be	AUX
biomedich-119	123	19	the	the	DET
biomedich-119	123	20	only	only	ADJ
biomedich-119	123	21	cure	cure	NOUN
biomedich-119	123	22	for	for	ADP
biomedich-119	123	23	t1d	t1d	PROPN
biomedich-119	123	24	(	(	PUNCT
biomedich-119	123	25	aghazadeh	aghazadeh	NOUN
biomedich-119	123	26	et	et	PROPN
biomedich-119	123	27	al	al	PROPN
biomedich-119	123	28	.	.	PROPN
biomedich-119	123	29	,	,	PUNCT
biomedich-119	123	30	2017	2017	NUM
biomedich-119	123	31	)	)	PUNCT
biomedich-119	123	32	.	.	PUNCT
biomedich-119	124	1	the	the	DET
biomedich-119	124	2	urgent	urgent	ADJ
biomedich-119	124	3	need	need	NOUN
biomedich-119	124	4	for	for	ADP
biomedich-119	124	5	a	a	DET
biomedich-119	124	6	much	much	ADV
biomedich-119	124	7	anticipated	anticipate	VERB
biomedich-119	124	8	insulin	insulin	NOUN
biomedich-119	124	9	-	-	PUNCT
biomedich-119	124	10	secreting	secrete	VERB
biomedich-119	124	11	substitute	substitute	NOUN
biomedich-119	124	12	for	for	ADP
biomedich-119	124	13	β	β	NOUN
biomedich-119	124	14	-	-	NOUN
biomedich-119	124	15	cells	cell	NOUN
biomedich-119	124	16	led	lead	VERB
biomedich-119	124	17	researchers	researcher	NOUN
biomedich-119	124	18	to	to	PART
biomedich-119	124	19	focus	focus	VERB
biomedich-119	124	20	on	on	ADP
biomedich-119	124	21	stem	stem	NOUN
biomedich-119	124	22	cells	cell	NOUN
biomedich-119	124	23	(	(	PUNCT
biomedich-119	124	24	scs	scs	PROPN
biomedich-119	124	25	)	)	PUNCT
biomedich-119	124	26	to	to	PART
biomedich-119	124	27	produce	produce	VERB
biomedich-119	124	28	insulin	insulin	NOUN
biomedich-119	124	29	-	-	PUNCT
biomedich-119	124	30	secreting	secrete	VERB
biomedich-119	124	31	β	β	NOUN
biomedich-119	124	32	-	-	NOUN
biomedich-119	124	33	cells	cell	NOUN
biomedich-119	124	34	.	.	PUNCT
biomedich-119	125	1	sc	sc	NOUN
biomedich-119	125	2	-	-	PUNCT
biomedich-119	125	3	based	base	VERB
biomedich-119	125	4	methods	method	NOUN
biomedich-119	125	5	have	have	AUX
biomedich-119	125	6	opened	open	VERB
biomedich-119	125	7	up	up	ADP
biomedich-119	125	8	the	the	DET
biomedich-119	125	9	new	new	ADJ
biomedich-119	125	10	horizons	horizon	NOUN
biomedich-119	125	11	to	to	PART
biomedich-119	125	12	treat	treat	VERB
biomedich-119	125	13	t1	t1	PROPN
biomedich-119	125	14	dm	dm	NOUN
biomedich-119	125	15	for	for	ADP
biomedich-119	125	16	being	be	AUX
biomedich-119	125	17	more	more	ADV
biomedich-119	125	18	precise	precise	ADJ
biomedich-119	125	19	and	and	CCONJ
biomedich-119	125	20	focused	focus	VERB
biomedich-119	125	21	therapeutic	therapeutic	ADJ
biomedich-119	125	22	approaches	approach	NOUN
biomedich-119	125	23	(	(	PUNCT
biomedich-119	125	24	farooq	farooq	PROPN
biomedich-119	125	25	et	et	PROPN
biomedich-119	125	26	al	al	PROPN
biomedich-119	125	27	.	.	PROPN
biomedich-119	125	28	,	,	PUNCT
biomedich-119	125	29	2019	2019	NUM
biomedich-119	125	30	)	)	PUNCT
biomedich-119	125	31	.	.	PUNCT
biomedich-119	126	1	replacing	replace	VERB
biomedich-119	126	2	pancreatic	pancreatic	ADJ
biomedich-119	126	3	islets	islet	NOUN
biomedich-119	126	4	with	with	ADP
biomedich-119	126	5	corpse	corpse	NOUN
biomedich-119	126	6	-	-	PUNCT
biomedich-119	126	7	derived	derive	VERB
biomedich-119	126	8	islets	islet	NOUN
biomedich-119	126	9	has	have	AUX
biomedich-119	126	10	proven	prove	VERB
biomedich-119	126	11	to	to	PART
biomedich-119	126	12	be	be	AUX
biomedich-119	126	13	a	a	DET
biomedich-119	126	14	successful	successful	ADJ
biomedich-119	126	15	functional	functional	ADJ
biomedich-119	126	16	cure	cure	NOUN
biomedich-119	126	17	for	for	ADP
biomedich-119	126	18	some	some	DET
biomedich-119	126	19	t1d	t1d	PROPN
biomedich-119	126	20	patients	patient	NOUN
biomedich-119	126	21	which	which	PRON
biomedich-119	126	22	allows	allow	VERB
biomedich-119	126	23	smail	smail	NOUN
biomedich-119	126	24	–	–	PUNCT
biomedich-119	126	25	the	the	DET
biomedich-119	126	26	role	role	NOUN
biomedich-119	126	27	of	of	ADP
biomedich-119	126	28	gene	gene	NOUN
biomedich-119	126	29	therapy	therapy	NOUN
biomedich-119	126	30	in	in	ADP
biomedich-119	126	31	the	the	DET
biomedich-119	126	32	treatments	treatment	NOUN
biomedich-119	126	33	of	of	ADP
biomedich-119	126	34	…	…	PUNCT
biomedich-119	126	35	61	61	NUM
biomedich-119	126	36	them	they	PRON
biomedich-119	126	37	to	to	PART
biomedich-119	126	38	be	be	AUX
biomedich-119	126	39	independent	independent	ADJ
biomedich-119	126	40	of	of	ADP
biomedich-119	126	41	exogenous	exogenous	ADJ
biomedich-119	126	42	insulin	insulin	NOUN
biomedich-119	126	43	(	(	PUNCT
biomedich-119	126	44	sluch	sluch	ADJ
biomedich-119	126	45	et	et	PROPN
biomedich-119	126	46	al	al	PROPN
biomedich-119	126	47	.	.	PROPN
biomedich-119	126	48	,	,	PUNCT
biomedich-119	126	49	2019	2019	NUM
biomedich-119	126	50	)	)	PUNCT
biomedich-119	126	51	.	.	PUNCT
biomedich-119	127	1	there	there	PRON
biomedich-119	127	2	was	be	VERB
biomedich-119	127	3	an	an	DET
biomedich-119	127	4	explosion	explosion	NOUN
biomedich-119	127	5	of	of	ADP
biomedich-119	127	6	interest	interest	NOUN
biomedich-119	127	7	in	in	ADP
biomedich-119	127	8	developing	develop	VERB
biomedich-119	127	9	methods	method	NOUN
biomedich-119	127	10	for	for	ADP
biomedich-119	127	11	transplantation	transplantation	NOUN
biomedich-119	127	12	to	to	PART
biomedich-119	127	13	replace	replace	VERB
biomedich-119	127	14	the	the	DET
biomedich-119	127	15	islets	islet	NOUN
biomedich-119	127	16	lost	lose	VERB
biomedich-119	127	17	during	during	ADP
biomedich-119	127	18	natural	natural	ADJ
biomedich-119	127	19	diabetes	diabetes	NOUN
biomedich-119	127	20	development	development	NOUN
biomedich-119	127	21	(	(	PUNCT
biomedich-119	127	22	emerich	emerich	PROPN
biomedich-119	127	23	,	,	PUNCT
biomedich-119	127	24	2002	2002	NUM
biomedich-119	127	25	)	)	PUNCT
biomedich-119	127	26	.	.	PUNCT
biomedich-119	128	1	clinically	clinically	ADV
biomedich-119	128	2	appropriate	appropriate	ADJ
biomedich-119	128	3	and	and	CCONJ
biomedich-119	128	4	healthy	healthy	ADJ
biomedich-119	128	5	,	,	PUNCT
biomedich-119	128	6	the	the	DET
biomedich-119	128	7	procedure	procedure	NOUN
biomedich-119	128	8	is	be	AUX
biomedich-119	128	9	associated	associate	VERB
biomedich-119	128	10	with	with	ADP
biomedich-119	128	11	a	a	DET
biomedich-119	128	12	low	low	ADJ
biomedich-119	128	13	risk	risk	NOUN
biomedich-119	128	14	of	of	ADP
biomedich-119	128	15	adverse	adverse	ADJ
biomedich-119	128	16	effects	effect	NOUN
biomedich-119	128	17	(	(	PUNCT
biomedich-119	128	18	ahrén	ahrén	PROPN
biomedich-119	128	19	,	,	PUNCT
biomedich-119	128	20	2011	2011	NUM
biomedich-119	128	21	)	)	PUNCT
biomedich-119	128	22	.	.	PUNCT
biomedich-119	129	1	clinical	clinical	ADJ
biomedich-119	129	2	trials	trial	NOUN
biomedich-119	129	3	to	to	PART
biomedich-119	129	4	improve	improve	VERB
biomedich-119	129	5	the	the	DET
biomedich-119	129	6	engraving	engraving	NOUN
biomedich-119	129	7	,	,	PUNCT
biomedich-119	129	8	the	the	DET
biomedich-119	129	9	availability	availability	NOUN
biomedich-119	129	10	of	of	ADP
biomedich-119	129	11	insulin	insulin	NOUN
biomedich-119	129	12	-	-	PUNCT
biomedich-119	129	13	producing	produce	VERB
biomedich-119	129	14	cell	cell	NOUN
biomedich-119	129	15	sources	source	NOUN
biomedich-119	129	16	and	and	CCONJ
biomedich-119	129	17	alternative	alternative	ADJ
biomedich-119	129	18	transplant	transplant	NOUN
biomedich-119	129	19	sites	site	NOUN
biomedich-119	129	20	are	be	AUX
biomedich-119	129	21	currently	currently	ADV
biomedich-119	129	22	under	under	ADP
biomedich-119	129	23	investigation	investigation	NOUN
biomedich-119	129	24	to	to	PART
biomedich-119	129	25	expand	expand	VERB
biomedich-119	129	26	treatment	treatment	NOUN
biomedich-119	129	27	(	(	PUNCT
biomedich-119	129	28	bruni	bruni	PROPN
biomedich-119	129	29	et	et	PROPN
biomedich-119	129	30	al	al	PROPN
biomedich-119	129	31	.	.	PROPN
biomedich-119	129	32	,	,	PUNCT
biomedich-119	129	33	2014	2014	NUM
biomedich-119	129	34	)	)	PUNCT
biomedich-119	129	35	.	.	PUNCT
biomedich-119	130	1	glucagon	glucagon	NOUN
biomedich-119	130	2	-	-	PUNCT
biomedich-119	130	3	like	like	ADJ
biomedich-119	130	4	peptide	peptide	NOUN
biomedich-119	130	5	1(glp-1	1(glp-1	NUM
biomedich-119	130	6	)	)	PUNCT
biomedich-119	131	1	analogs	analog	NOUN
biomedich-119	131	2	and	and	CCONJ
biomedich-119	131	3	alternative	alternative	ADJ
biomedich-119	131	4	insulin	insulin	NOUN
biomedich-119	131	5	pathways	pathway	NOUN
biomedich-119	131	6	,	,	PUNCT
biomedich-119	131	7	particularly	particularly	ADV
biomedich-119	131	8	oral	oral	ADJ
biomedich-119	131	9	(	(	PUNCT
biomedich-119	131	10	entericgastrointestinal	entericgastrointestinal	ADJ
biomedich-119	131	11	,	,	PUNCT
biomedich-119	131	12	inhaled	inhaled	ADJ
biomedich-119	131	13	)	)	PUNCT
biomedich-119	131	14	pathways	pathway	NOUN
biomedich-119	131	15	,	,	PUNCT
biomedich-119	131	16	are	be	AUX
biomedich-119	131	17	now	now	ADV
biomedich-119	131	18	most	most	ADV
biomedich-119	131	19	promising	promising	ADJ
biomedich-119	131	20	and	and	CCONJ
biomedich-119	131	21	attractive	attractive	ADJ
biomedich-119	131	22	(	(	PUNCT
biomedich-119	131	23	takei	takei	PROPN
biomedich-119	131	24	et	et	PROPN
biomedich-119	131	25	al	al	PROPN
biomedich-119	131	26	.	.	PROPN
biomedich-119	131	27	,	,	PUNCT
biomedich-119	131	28	2004	2004	NUM
biomedich-119	131	29	)	)	PUNCT
biomedich-119	131	30	.	.	PUNCT
biomedich-119	132	1	conclusions	conclusion	NOUN
biomedich-119	132	2	i	i	PRON
biomedich-119	132	3	have	have	AUX
biomedich-119	132	4	come	come	VERB
biomedich-119	132	5	to	to	ADP
biomedich-119	132	6	the	the	DET
biomedich-119	132	7	following	follow	VERB
biomedich-119	132	8	conclusions	conclusion	NOUN
biomedich-119	132	9	from	from	ADP
biomedich-119	132	10	the	the	DET
biomedich-119	132	11	review	review	NOUN
biomedich-119	132	12	:	:	PUNCT
biomedich-119	132	13	the	the	DET
biomedich-119	132	14	gene	gene	NOUN
biomedich-119	132	15	therapy	therapy	NOUN
biomedich-119	132	16	production	production	NOUN
biomedich-119	132	17	and	and	CCONJ
biomedich-119	132	18	uses	use	NOUN
biomedich-119	132	19	have	have	AUX
biomedich-119	132	20	increased	increase	VERB
biomedich-119	132	21	significantly	significantly	ADV
biomedich-119	132	22	over	over	ADP
biomedich-119	132	23	periodic	periodic	ADJ
biomedich-119	132	24	time	time	NOUN
biomedich-119	132	25	.	.	PUNCT
biomedich-119	133	1	gene	gene	NOUN
biomedich-119	133	2	therapy	therapy	NOUN
biomedich-119	133	3	has	have	VERB
biomedich-119	133	4	a	a	DET
biomedich-119	133	5	reduced	reduce	VERB
biomedich-119	133	6	role	role	NOUN
biomedich-119	133	7	in	in	ADP
biomedich-119	133	8	the	the	DET
biomedich-119	133	9	secondary	secondary	ADJ
biomedich-119	133	10	complication	complication	NOUN
biomedich-119	133	11	of	of	ADP
biomedich-119	133	12	diabetes	diabetes	NOUN
biomedich-119	133	13	mellitus	mellitus	NOUN
biomedich-119	133	14	,	,	PUNCT
biomedich-119	133	15	and	and	CCONJ
biomedich-119	133	16	can	can	AUX
biomedich-119	133	17	be	be	AUX
biomedich-119	133	18	a	a	DET
biomedich-119	133	19	strong	strong	ADJ
biomedich-119	133	20	option	option	NOUN
biomedich-119	133	21	for	for	ADP
biomedich-119	133	22	diabetic	diabetic	ADJ
biomedich-119	133	23	patients	patient	NOUN
biomedich-119	133	24	.	.	PUNCT
biomedich-119	134	1	conflict	conflict	NOUN
biomedich-119	134	2	of	of	ADP
biomedich-119	134	3	interest	interest	NOUN
biomedich-119	134	4	:	:	PUNCT
biomedich-119	134	5	the	the	DET
biomedich-119	134	6	author	author	NOUN
biomedich-119	134	7	declares	declare	VERB
biomedich-119	134	8	that	that	SCONJ
biomedich-119	134	9	there	there	PRON
biomedich-119	134	10	are	be	VERB
biomedich-119	134	11	no	no	DET
biomedich-119	134	12	conflicts	conflict	NOUN
biomedich-119	134	13	of	of	ADP
biomedich-119	134	14	interest	interest	NOUN
biomedich-119	134	15	concerning	concern	VERB
biomedich-119	134	16	the	the	DET
biomedich-119	134	17	publication	publication	NOUN
biomedich-119	134	18	of	of	ADP
biomedich-119	134	19	this	this	DET
biomedich-119	134	20	article	article	NOUN
biomedich-119	134	21	.	.	PUNCT
biomedich-119	135	1	references	reference	NOUN
biomedich-119	135	2	ackeifi	ackeifi	PROPN
biomedich-119	135	3	,	,	PUNCT
biomedich-119	135	4	c.	c.	PROPN
biomedich-119	135	5	,	,	PUNCT
biomedich-119	135	6	wang	wang	PROPN
biomedich-119	135	7	,	,	PUNCT
biomedich-119	135	8	p.	p.	PROPN
biomedich-119	135	9	,	,	PUNCT
biomedich-119	135	10	karakose	karakose	PROPN
biomedich-119	135	11	,	,	PUNCT
biomedich-119	135	12	e.	e.	PROPN
biomedich-119	135	13	,	,	PUNCT
biomedich-119	135	14	fox	fox	PROPN
biomedich-119	135	15	,	,	PUNCT
biomedich-119	135	16	j.e.m	j.e.m	PROPN
biomedich-119	135	17	.	.	PROPN
biomedich-119	135	18	,	,	PUNCT
biomedich-119	135	19	gonzález	gonzález	PROPN
biomedich-119	135	20	,	,	PUNCT
biomedich-119	135	21	b.j	b.j	PROPN
biomedich-119	135	22	.	.	PROPN
biomedich-119	135	23	,	,	PUNCT
biomedich-119	135	24	liu	liu	PROPN
biomedich-119	135	25	,	,	PUNCT
biomedich-119	135	26	h.	h.	PROPN
biomedich-119	135	27	,	,	PUNCT
biomedich-119	135	28	wilson	wilson	PROPN
biomedich-119	135	29	,	,	PUNCT
biomedich-119	135	30	j.	j.	PROPN
biomedich-119	135	31	,	,	PUNCT
biomedich-119	135	32	swartz	swartz	PROPN
biomedich-119	135	33	,	,	PUNCT
biomedich-119	135	34	e.	e.	PROPN
biomedich-119	135	35	,	,	PUNCT
biomedich-119	135	36	berrouet	berrouet	VERB
biomedich-119	135	37	,	,	PUNCT
biomedich-119	135	38	c.	c.	PROPN
biomedich-119	135	39	,	,	PUNCT
biomedich-119	135	40	li	li	PROPN
biomedich-119	135	41	,	,	PUNCT
biomedich-119	135	42	y.	y.	PROPN
biomedich-119	135	43	and	and	CCONJ
biomedich-119	135	44	kumar	kumar	PROPN
biomedich-119	135	45	,	,	PUNCT
biomedich-119	135	46	k.	k.	PROPN
biomedich-119	135	47	,	,	PUNCT
biomedich-119	135	48	2020	2020	NUM
biomedich-119	135	49	.	.	PUNCT
biomedich-119	136	1	glp-1	glp-1	NOUN
biomedich-119	136	2	receptor	receptor	NOUN
biomedich-119	136	3	agonists	agonist	NOUN
biomedich-119	136	4	synergize	synergize	VERB
biomedich-119	136	5	with	with	ADP
biomedich-119	136	6	dyrk1a	dyrk1a	PROPN
biomedich-119	136	7	inhibitors	inhibitor	NOUN
biomedich-119	136	8	to	to	PART
biomedich-119	136	9	potentiate	potentiate	VERB
biomedich-119	136	10	functional	functional	ADJ
biomedich-119	136	11	human	human	PROPN
biomedich-119	136	12	β	β	PROPN
biomedich-119	136	13	cell	cell	NOUN
biomedich-119	136	14	regeneration	regeneration	NOUN
biomedich-119	136	15	.	.	PUNCT
biomedich-119	137	1	science	science	NOUN
biomedich-119	137	2	translational	translational	ADJ
biomedich-119	137	3	medicine	medicine	NOUN
biomedich-119	137	4	,	,	PUNCT
biomedich-119	137	5	12(530	12(530	NOUN
biomedich-119	137	6	)	)	PUNCT
biomedich-119	137	7	.	.	PUNCT
biomedich-119	138	1	afzal	afzal	PROPN
biomedich-119	138	2	,	,	PUNCT
biomedich-119	138	3	s.	s.	PROPN
biomedich-119	138	4	,	,	PUNCT
biomedich-119	138	5	fronza	fronza	PROPN
biomedich-119	138	6	,	,	PUNCT
biomedich-119	138	7	r.	r.	PROPN
biomedich-119	138	8	and	and	CCONJ
biomedich-119	138	9	schmidt	schmidt	PROPN
biomedich-119	138	10	,	,	PUNCT
biomedich-119	138	11	m.	m.	NOUN
biomedich-119	138	12	,	,	PUNCT
biomedich-119	138	13	2020	2020	NUM
biomedich-119	138	14	.	.	PUNCT
biomedich-119	139	1	vseq	vseq	NOUN
biomedich-119	139	2	-	-	PUNCT
biomedich-119	139	3	toolkit	toolkit	NOUN
biomedich-119	139	4	:	:	PUNCT
biomedich-119	139	5	comprehensive	comprehensive	ADJ
biomedich-119	139	6	computational	computational	ADJ
biomedich-119	139	7	analysis	analysis	NOUN
biomedich-119	139	8	of	of	ADP
biomedich-119	139	9	viral	viral	ADJ
biomedich-119	139	10	vectors	vector	NOUN
biomedich-119	139	11	in	in	ADP
biomedich-119	139	12	gene	gene	NOUN
biomedich-119	139	13	therapy	therapy	NOUN
biomedich-119	139	14	.	.	PUNCT
biomedich-119	140	1	molecular	molecular	ADJ
biomedich-119	140	2	therapy	therapy	NOUN
biomedich-119	140	3	-	-	PUNCT
biomedich-119	140	4	methods	method	NOUN
biomedich-119	140	5	&	&	CCONJ
biomedich-119	140	6	clinical	clinical	ADJ
biomedich-119	140	7	development	development	NOUN
biomedich-119	140	8	.	.	PUNCT
biomedich-119	141	1	aghazadeh	aghazadeh	PROPN
biomedich-119	141	2	,	,	PUNCT
biomedich-119	141	3	y.	y.	NOUN
biomedich-119	141	4	and	and	CCONJ
biomedich-119	141	5	nostro	nostro	PROPN
biomedich-119	141	6	,	,	PUNCT
biomedich-119	141	7	m.c	m.c	PROPN
biomedich-119	141	8	.	.	PROPN
biomedich-119	141	9	,	,	PUNCT
biomedich-119	141	10	2017	2017	NUM
biomedich-119	141	11	.	.	PUNCT
biomedich-119	142	1	cell	cell	NOUN
biomedich-119	142	2	therapy	therapy	NOUN
biomedich-119	142	3	for	for	ADP
biomedich-119	142	4	type	type	NOUN
biomedich-119	142	5	1	1	NUM
biomedich-119	142	6	diabetes	diabetes	NOUN
biomedich-119	142	7	:	:	PUNCT
biomedich-119	142	8	current	current	ADJ
biomedich-119	142	9	and	and	CCONJ
biomedich-119	142	10	future	future	ADJ
biomedich-119	142	11	strategies	strategy	NOUN
biomedich-119	142	12	.	.	PUNCT
biomedich-119	143	1	current	current	ADJ
biomedich-119	143	2	diabetes	diabetes	NOUN
biomedich-119	143	3	reports	report	NOUN
biomedich-119	143	4	,	,	PUNCT
biomedich-119	143	5	17(6	17(6	NUM
biomedich-119	143	6	)	)	PUNCT
biomedich-119	143	7	,	,	PUNCT
biomedich-119	143	8	p.37	p.37	PROPN
biomedich-119	143	9	.	.	PUNCT
biomedich-119	144	1	aguayo	aguayo	PROPN
biomedich-119	144	2	-	-	PUNCT
biomedich-119	144	3	mazzucato	mazzucato	PROPN
biomedich-119	144	4	,	,	PUNCT
biomedich-119	144	5	c.	c.	PROPN
biomedich-119	144	6	and	and	CCONJ
biomedich-119	144	7	bonner	bonner	PROPN
biomedich-119	144	8	-	-	PUNCT
biomedich-119	144	9	weir	weir	PROPN
biomedich-119	144	10	,	,	PUNCT
biomedich-119	144	11	s.	s.	PROPN
biomedich-119	144	12	,	,	PUNCT
biomedich-119	144	13	2010	2010	NUM
biomedich-119	144	14	.	.	PUNCT
biomedich-119	145	1	stem	stem	NOUN
biomedich-119	145	2	cell	cell	NOUN
biomedich-119	145	3	therapy	therapy	NOUN
biomedich-119	145	4	for	for	ADP
biomedich-119	145	5	type	type	NOUN
biomedich-119	145	6	1	1	NUM
biomedich-119	145	7	diabetes	diabetes	NOUN
biomedich-119	145	8	mellitus	mellitus	NOUN
biomedich-119	145	9	.	.	PUNCT
biomedich-119	146	1	nature	nature	NOUN
biomedich-119	146	2	reviews	review	VERB
biomedich-119	146	3	endocrinology	endocrinology	NOUN
biomedich-119	146	4	,	,	PUNCT
biomedich-119	146	5	6(3	6(3	NUM
biomedich-119	146	6	)	)	PUNCT
biomedich-119	146	7	,	,	PUNCT
biomedich-119	146	8	pp.139	pp.139	NOUN
biomedich-119	146	9	-	-	PUNCT
biomedich-119	146	10	148	148	NUM
biomedich-119	146	11	.	.	PUNCT
biomedich-119	147	1	ahrén	ahrén	PROPN
biomedich-119	147	2	,	,	PUNCT
biomedich-119	147	3	b.	b.	PROPN
biomedich-119	147	4	,	,	PUNCT
biomedich-119	147	5	2011	2011	NUM
biomedich-119	147	6	.	.	PUNCT
biomedich-119	148	1	the	the	DET
biomedich-119	148	2	future	future	NOUN
biomedich-119	148	3	of	of	ADP
biomedich-119	148	4	incretin‐based	incretin‐based	ADJ
biomedich-119	148	5	therapy	therapy	NOUN
biomedich-119	148	6	:	:	PUNCT
biomedich-119	148	7	novel	novel	ADJ
biomedich-119	148	8	avenues	avenue	NOUN
biomedich-119	148	9	—	—	PUNCT
biomedich-119	148	10	novel	novel	ADJ
biomedich-119	148	11	targets	target	NOUN
biomedich-119	148	12	.	.	PUNCT
biomedich-119	149	1	diabetes	diabetes	NOUN
biomedich-119	149	2	,	,	PUNCT
biomedich-119	149	3	obesity	obesity	NOUN
biomedich-119	149	4	and	and	CCONJ
biomedich-119	149	5	metabolism	metabolism	NOUN
biomedich-119	149	6	,	,	PUNCT
biomedich-119	149	7	13	13	NUM
biomedich-119	149	8	,	,	PUNCT
biomedich-119	149	9	pp.158	pp.158	NOUN
biomedich-119	149	10	-	-	SYM
biomedich-119	149	11	166	166	NUM
biomedich-119	149	12	.	.	PUNCT
biomedich-119	150	1	akirav	akirav	PROPN
biomedich-119	150	2	,	,	PUNCT
biomedich-119	150	3	e.	e.	PROPN
biomedich-119	150	4	,	,	PUNCT
biomedich-119	150	5	kushner	kushner	PROPN
biomedich-119	150	6	,	,	PUNCT
biomedich-119	150	7	j.a	j.a	PROPN
biomedich-119	150	8	.	.	PROPN
biomedich-119	150	9	and	and	CCONJ
biomedich-119	150	10	herold	herold	PROPN
biomedich-119	150	11	,	,	PUNCT
biomedich-119	150	12	k.c	k.c	PROPN
biomedich-119	150	13	.	.	PROPN
biomedich-119	150	14	,	,	PUNCT
biomedich-119	150	15	2008	2008	NUM
biomedich-119	150	16	.	.	PUNCT
biomedich-119	151	1	β	β	X
biomedich-119	151	2	-	-	PUNCT
biomedich-119	151	3	cell	cell	NOUN
biomedich-119	151	4	mass	mass	NOUN
biomedich-119	151	5	and	and	CCONJ
biomedich-119	151	6	type	type	NOUN
biomedich-119	151	7	1	1	NUM
biomedich-119	151	8	diabetes	diabetes	NOUN
biomedich-119	151	9	:	:	PUNCT
biomedich-119	151	10	going	go	VERB
biomedich-119	151	11	,	,	PUNCT
biomedich-119	151	12	going	go	VERB
biomedich-119	151	13	,	,	PUNCT
biomedich-119	151	14	gone	go	VERB
biomedich-119	151	15	?	?	PUNCT
biomedich-119	151	16	.	.	PUNCT
biomedich-119	152	1	diabetes	diabetes	NOUN
biomedich-119	152	2	,	,	PUNCT
biomedich-119	152	3	57(11	57(11	NUM
biomedich-119	152	4	)	)	PUNCT
biomedich-119	152	5	,	,	PUNCT
biomedich-119	152	6	pp.2883	pp.2883	PROPN
biomedich-119	152	7	-	-	PUNCT
biomedich-119	152	8	2888	2888	NUM
biomedich-119	152	9	.	.	PUNCT
biomedich-119	153	1	al	al	PROPN
biomedich-119	153	2	ghofaili	ghofaili	PROPN
biomedich-119	153	3	,	,	PUNCT
biomedich-119	153	4	k.	k.	PROPN
biomedich-119	153	5	,	,	PUNCT
biomedich-119	153	6	fung	fung	PROPN
biomedich-119	153	7	,	,	PUNCT
biomedich-119	153	8	m.	m.	NOUN
biomedich-119	153	9	,	,	PUNCT
biomedich-119	153	10	ao	ao	PROPN
biomedich-119	153	11	,	,	PUNCT
biomedich-119	153	12	z.	z.	PROPN
biomedich-119	153	13	,	,	PUNCT
biomedich-119	153	14	meloche	meloche	PROPN
biomedich-119	153	15	,	,	PUNCT
biomedich-119	153	16	m.	m.	NOUN
biomedich-119	153	17	,	,	PUNCT
biomedich-119	153	18	shapiro	shapiro	PROPN
biomedich-119	153	19	,	,	PUNCT
biomedich-119	153	20	r.j	r.j	PROPN
biomedich-119	153	21	.	.	PROPN
biomedich-119	153	22	,	,	PUNCT
biomedich-119	153	23	warnock	warnock	PROPN
biomedich-119	153	24	,	,	PUNCT
biomedich-119	153	25	g.l	g.l	PROPN
biomedich-119	153	26	.	.	PROPN
biomedich-119	153	27	,	,	PUNCT
biomedich-119	153	28	elahi	elahi	PROPN
biomedich-119	153	29	,	,	PUNCT
biomedich-119	153	30	d.	d.	PROPN
biomedich-119	153	31	,	,	PUNCT
biomedich-119	153	32	meneilly	meneilly	ADV
biomedich-119	153	33	,	,	PUNCT
biomedich-119	153	34	g.s	g.s	PROPN
biomedich-119	153	35	.	.	PROPN
biomedich-119	153	36	and	and	CCONJ
biomedich-119	153	37	thompson	thompson	PROPN
biomedich-119	153	38	,	,	PUNCT
biomedich-119	153	39	d.m	d.m	PROPN
biomedich-119	153	40	.	.	PROPN
biomedich-119	153	41	,	,	PUNCT
biomedich-119	153	42	2007	2007	NUM
biomedich-119	153	43	.	.	PUNCT
biomedich-119	154	1	effect	effect	NOUN
biomedich-119	154	2	of	of	ADP
biomedich-119	154	3	exenatide	exenatide	NOUN
biomedich-119	154	4	on	on	ADP
biomedich-119	154	5	β	β	X
biomedich-119	154	6	cell	cell	NOUN
biomedich-119	154	7	function	function	NOUN
biomedich-119	154	8	after	after	ADP
biomedich-119	154	9	islet	islet	NOUN
biomedich-119	154	10	transplantation	transplantation	NOUN
biomedich-119	154	11	in	in	ADP
biomedich-119	154	12	type	type	NOUN
biomedich-119	154	13	1	1	NUM
biomedich-119	154	14	diabetes	diabetes	NOUN
biomedich-119	154	15	.	.	PUNCT
biomedich-119	155	1	transplantation	transplantation	NOUN
biomedich-119	155	2	,	,	PUNCT
biomedich-119	155	3	83(1	83(1	PROPN
biomedich-119	155	4	)	)	PUNCT
biomedich-119	155	5	,	,	PUNCT
biomedich-119	155	6	pp.24	pp.24	NOUN
biomedich-119	155	7	-	-	PUNCT
biomedich-119	155	8	28	28	NUM
biomedich-119	155	9	.	.	PUNCT
biomedich-119	156	1	alleva	alleva	PROPN
biomedich-119	156	2	,	,	PUNCT
biomedich-119	156	3	d.g	d.g	PROPN
biomedich-119	156	4	.	.	PROPN
biomedich-119	156	5	,	,	PUNCT
biomedich-119	156	6	rezaee	rezaee	PROPN
biomedich-119	156	7	,	,	PUNCT
biomedich-119	156	8	m.	m.	NOUN
biomedich-119	156	9	,	,	PUNCT
biomedich-119	156	10	yip	yip	PROPN
biomedich-119	156	11	,	,	PUNCT
biomedich-119	156	12	l.	l.	PROPN
biomedich-119	156	13	,	,	PUNCT
biomedich-119	156	14	ren	ren	PROPN
biomedich-119	156	15	,	,	PUNCT
biomedich-119	156	16	g.	g.	PROPN
biomedich-119	156	17	,	,	PUNCT
biomedich-119	156	18	rosenberg	rosenberg	PROPN
biomedich-119	156	19	,	,	PUNCT
biomedich-119	156	20	j.	j.	PROPN
biomedich-119	156	21	,	,	PUNCT
biomedich-119	156	22	concepcion	concepcion	PROPN
biomedich-119	156	23	,	,	PUNCT
biomedich-119	156	24	w.	w.	PROPN
biomedich-119	156	25	,	,	PUNCT
biomedich-119	156	26	escher	escher	PROPN
biomedich-119	156	27	,	,	PUNCT
biomedich-119	156	28	a.	a.	PROPN
biomedich-119	156	29	,	,	PUNCT
biomedich-119	156	30	shabahang	shabahang	PROPN
biomedich-119	156	31	,	,	PUNCT
biomedich-119	156	32	s.	s.	PROPN
biomedich-119	156	33	and	and	CCONJ
biomedich-119	156	34	thakor	thakor	PROPN
biomedich-119	156	35	,	,	PUNCT
biomedich-119	156	36	a.s	a.s	PROPN
biomedich-119	156	37	.	.	PROPN
biomedich-119	156	38	,	,	PUNCT
biomedich-119	156	39	2020	2020	NUM
biomedich-119	156	40	.	.	PUNCT
biomedich-119	157	1	reversal	reversal	NOUN
biomedich-119	157	2	of	of	ADP
biomedich-119	157	3	hyperglycemia	hyperglycemia	NOUN
biomedich-119	157	4	and	and	CCONJ
biomedich-119	157	5	suppression	suppression	NOUN
biomedich-119	157	6	of	of	ADP
biomedich-119	157	7	type	type	NOUN
biomedich-119	157	8	1	1	NUM
biomedich-119	157	9	diabetes	diabetes	NOUN
biomedich-119	157	10	in	in	ADP
biomedich-119	157	11	the	the	DET
biomedich-119	157	12	nod	nod	PROPN
biomedich-119	157	13	mouse	mouse	NOUN
biomedich-119	157	14	with	with	ADP
biomedich-119	157	15	apoptotic	apoptotic	ADJ
biomedich-119	157	16	dna	dna	PROPN
biomedich-119	157	17	immunotherapy	immunotherapy	NOUN
biomedich-119	157	18	™	™	NOUN
biomedich-119	157	19	(adi	(adi	X
biomedich-119	157	20	™	™	NOUN
biomedich-119	157	21	)	)	PUNCT
biomedich-119	157	22	,	,	PUNCT
biomedich-119	157	23	adi-100	adi-100	PROPN
biomedich-119	157	24	.	.	PUNCT
biomedich-119	158	1	biomedicines	biomedicines	PROPN
biomedich-119	158	2	,	,	PUNCT
biomedich-119	158	3	8(3	8(3	NUM
biomedich-119	158	4	)	)	PUNCT
biomedich-119	158	5	,	,	PUNCT
biomedich-119	158	6	p.53	p.53	PROPN
biomedich-119	158	7	.	.	PROPN
biomedich-119	158	8	apaya	apaya	PROPN
biomedich-119	158	9	,	,	PUNCT
biomedich-119	158	10	m.k	m.k	PROPN
biomedich-119	158	11	.	.	PROPN
biomedich-119	158	12	,	,	PUNCT
biomedich-119	158	13	kuo	kuo	PROPN
biomedich-119	158	14	,	,	PUNCT
biomedich-119	158	15	t.f	t.f	PROPN
biomedich-119	158	16	.	.	PROPN
biomedich-119	158	17	,	,	PUNCT
biomedich-119	158	18	yang	yang	PROPN
biomedich-119	158	19	,	,	PUNCT
biomedich-119	158	20	m.t	m.t	PROPN
biomedich-119	158	21	.	.	PROPN
biomedich-119	158	22	,	,	PUNCT
biomedich-119	158	23	yang	yang	PROPN
biomedich-119	158	24	,	,	PUNCT
biomedich-119	158	25	g.	g.	PROPN
biomedich-119	158	26	,	,	PUNCT
biomedich-119	158	27	hsiao	hsiao	PROPN
biomedich-119	158	28	,	,	PUNCT
biomedich-119	158	29	c.l	c.l	PROPN
biomedich-119	158	30	.	.	PROPN
biomedich-119	158	31	,	,	PUNCT
biomedich-119	158	32	chang	chang	PROPN
biomedich-119	158	33	,	,	PUNCT
biomedich-119	158	34	s.b	s.b	PROPN
biomedich-119	158	35	.	.	PROPN
biomedich-119	158	36	,	,	PUNCT
biomedich-119	158	37	lin	lin	PROPN
biomedich-119	158	38	,	,	PUNCT
biomedich-119	158	39	y.	y.	PROPN
biomedich-119	158	40	and	and	CCONJ
biomedich-119	158	41	yang	yang	PROPN
biomedich-119	158	42	,	,	PUNCT
biomedich-119	158	43	w.c	w.c	PROPN
biomedich-119	158	44	.	.	PROPN
biomedich-119	158	45	,	,	PUNCT
biomedich-119	158	46	2020	2020	NUM
biomedich-119	158	47	.	.	PUNCT
biomedich-119	159	1	phytochemicals	phytochemical	NOUN
biomedich-119	159	2	as	as	ADP
biomedich-119	159	3	modulators	modulator	NOUN
biomedich-119	159	4	of	of	ADP
biomedich-119	159	5	β	β	NOUN
biomedich-119	159	6	-	-	NOUN
biomedich-119	159	7	cells	cell	NOUN
biomedich-119	159	8	and	and	CCONJ
biomedich-119	159	9	immunity	immunity	NOUN
biomedich-119	159	10	for	for	ADP
biomedich-119	159	11	the	the	DET
biomedich-119	159	12	therapy	therapy	NOUN
biomedich-119	159	13	of	of	ADP
biomedich-119	159	14	type	type	NOUN
biomedich-119	159	15	1	1	NUM
biomedich-119	159	16	diabetes	diabete	NOUN
biomedich-119	159	17	:	:	PUNCT
biomedich-119	159	18	recent	recent	ADJ
biomedich-119	159	19	discoveries	discovery	NOUN
biomedich-119	159	20	in	in	ADP
biomedich-119	159	21	pharmacological	pharmacological	ADJ
biomedich-119	159	22	mechanisms	mechanism	NOUN
biomedich-119	159	23	and	and	CCONJ
biomedich-119	159	24	clinical	clinical	ADJ
biomedich-119	159	25	potential	potential	NOUN
biomedich-119	159	26	.	.	PUNCT
biomedich-119	160	1	pharmacological	pharmacological	ADJ
biomedich-119	160	2	research	research	NOUN
biomedich-119	160	3	,	,	PUNCT
biomedich-119	160	4	p.104754	p.104754	PROPN
biomedich-119	160	5	.	.	PROPN
biomedich-119	160	6	arjmand	arjmand	PROPN
biomedich-119	160	7	,	,	PUNCT
biomedich-119	160	8	b.	b.	PROPN
biomedich-119	160	9	,	,	PUNCT
biomedich-119	160	10	alavi	alavi	NOUN
biomedich-119	160	11	-	-	PUNCT
biomedich-119	160	12	moghadam	moghadam	NOUN
biomedich-119	160	13	,	,	PUNCT
biomedich-119	160	14	s.	s.	PROPN
biomedich-119	160	15	,	,	PUNCT
biomedich-119	160	16	payab	payab	NOUN
biomedich-119	160	17	,	,	PUNCT
biomedich-119	160	18	m.	m.	NOUN
biomedich-119	160	19	,	,	PUNCT
biomedich-119	160	20	goodarzi	goodarzi	NOUN
biomedich-119	160	21	,	,	PUNCT
biomedich-119	160	22	p.	p.	PROPN
biomedich-119	160	23	,	,	PUNCT
biomedich-119	160	24	hosseini	hosseini	PROPN
biomedich-119	160	25	,	,	PUNCT
biomedich-119	160	26	m.s	m.s	PROPN
biomedich-119	160	27	.	.	PROPN
biomedich-119	160	28	,	,	PUNCT
biomedich-119	160	29	tayanloo	tayanloo	NOUN
biomedich-119	160	30	-	-	PUNCT
biomedich-119	160	31	beik	beik	PROPN
biomedich-119	160	32	,	,	PUNCT
biomedich-119	160	33	a.	a.	NOUN
biomedich-119	160	34	,	,	PUNCT
biomedich-119	160	35	rezaei	rezaei	NOUN
biomedich-119	160	36	-	-	PUNCT
biomedich-119	160	37	tavirani	tavirani	NOUN
biomedich-119	160	38	,	,	PUNCT
biomedich-119	160	39	m.	m.	NOUN
biomedich-119	160	40	and	and	CCONJ
biomedich-119	160	41	larijani	larijani	NOUN
biomedich-119	160	42	,	,	PUNCT
biomedich-119	160	43	b.	b.	PROPN
biomedich-119	160	44	,	,	PUNCT
biomedich-119	160	45	2020	2020	NUM
biomedich-119	160	46	.	.	PUNCT
biomedich-119	161	1	gmp	gmp	NOUN
biomedich-119	161	2	-	-	PUNCT
biomedich-119	161	3	compliant	compliant	ADJ
biomedich-119	161	4	adenoviral	adenoviral	ADJ
biomedich-119	161	5	vectors	vector	NOUN
biomedich-119	161	6	for	for	ADP
biomedich-119	161	7	gene	gene	NOUN
biomedich-119	161	8	therapy	therapy	NOUN
biomedich-119	161	9	.	.	PUNCT
biomedich-119	162	1	badr	badr	PROPN
biomedich-119	162	2	,	,	PUNCT
biomedich-119	162	3	a.m.	a.m.	ADV
biomedich-119	162	4	,	,	PUNCT
biomedich-119	162	5	sharkawy	sharkawy	PROPN
biomedich-119	162	6	,	,	PUNCT
biomedich-119	162	7	h.	h.	PROPN
biomedich-119	162	8	,	,	PUNCT
biomedich-119	162	9	farid	farid	PROPN
biomedich-119	162	10	,	,	PUNCT
biomedich-119	162	11	a.a	a.a	PROPN
biomedich-119	162	12	.	.	PROPN
biomedich-119	162	13	and	and	CCONJ
biomedich-119	162	14	el	el	PROPN
biomedich-119	162	15	-	-	PUNCT
biomedich-119	162	16	deeb	deeb	PROPN
biomedich-119	162	17	,	,	PUNCT
biomedich-119	162	18	s.	s.	PROPN
biomedich-119	162	19	,	,	PUNCT
biomedich-119	162	20	2020	2020	NUM
biomedich-119	162	21	.	.	PUNCT
biomedich-119	163	1	curcumin	curcumin	NOUN
biomedich-119	163	2	induces	induce	VERB
biomedich-119	163	3	regeneration	regeneration	NOUN
biomedich-119	163	4	of	of	ADP
biomedich-119	163	5	β	β	NOUN
biomedich-119	163	6	cells	cell	NOUN
biomedich-119	163	7	and	and	CCONJ
biomedich-119	163	8	suppression	suppression	NOUN
biomedich-119	163	9	of	of	ADP
biomedich-119	163	10	phosphorylated	phosphorylate	VERB
biomedich-119	163	11	-	-	PUNCT
biomedich-119	163	12	nf	nf	INTJ
biomedich-119	163	13	-	-	PUNCT
biomedich-119	163	14	κb	κb	NOUN
biomedich-119	163	15	in	in	ADP
biomedich-119	163	16	streptozotocin	streptozotocin	NOUN
biomedich-119	163	17	-	-	PUNCT
biomedich-119	163	18	induced	induce	VERB
biomedich-119	163	19	diabetic	diabetic	ADJ
biomedich-119	163	20	mice	mouse	NOUN
biomedich-119	163	21	.	.	PUNCT
biomedich-119	164	1	the	the	DET
biomedich-119	164	2	journal	journal	NOUN
biomedich-119	164	3	of	of	ADP
biomedich-119	164	4	basic	basic	ADJ
biomedich-119	164	5	and	and	CCONJ
biomedich-119	164	6	applied	apply	VERB
biomedich-119	164	7	zoology	zoology	NOUN
biomedich-119	164	8	,	,	PUNCT
biomedich-119	164	9	81	81	NUM
biomedich-119	164	10	,	,	PUNCT
biomedich-119	164	11	pp.1	pp.1	NOUN
biomedich-119	164	12	-	-	PUNCT
biomedich-119	164	13	15	15	NUM
biomedich-119	164	14	.	.	PUNCT
biomedich-119	165	1	bellin	bellin	PROPN
biomedich-119	165	2	,	,	PUNCT
biomedich-119	165	3	m.d	m.d	PROPN
biomedich-119	165	4	.	.	PROPN
biomedich-119	165	5	,	,	PUNCT
biomedich-119	165	6	barton	barton	PROPN
biomedich-119	165	7	,	,	PUNCT
biomedich-119	165	8	f.b	f.b	PROPN
biomedich-119	165	9	.	.	PROPN
biomedich-119	165	10	,	,	PUNCT
biomedich-119	165	11	heitman	heitman	NOUN
biomedich-119	165	12	,	,	PUNCT
biomedich-119	165	13	a.	a.	PROPN
biomedich-119	165	14	,	,	PUNCT
biomedich-119	165	15	harmon	harmon	PROPN
biomedich-119	165	16	,	,	PUNCT
biomedich-119	165	17	j.v	j.v	PROPN
biomedich-119	165	18	.	.	PROPN
biomedich-119	165	19	,	,	PUNCT
biomedich-119	165	20	kandaswamy	kandaswamy	PROPN
biomedich-119	165	21	,	,	PUNCT
biomedich-119	165	22	r.	r.	PROPN
biomedich-119	165	23	,	,	PUNCT
biomedich-119	165	24	balamurugan	balamurugan	VERB
biomedich-119	165	25	,	,	PUNCT
biomedich-119	165	26	a.n	a.n	PROPN
biomedich-119	165	27	.	.	PROPN
biomedich-119	165	28	,	,	PUNCT
biomedich-119	165	29	sutherland	sutherland	PROPN
biomedich-119	165	30	,	,	PUNCT
biomedich-119	165	31	d.e.r	d.e.r	NOUN
biomedich-119	165	32	.	.	PROPN
biomedich-119	165	33	,	,	PUNCT
biomedich-119	165	34	alejandro	alejandro	PROPN
biomedich-119	165	35	,	,	PUNCT
biomedich-119	165	36	r.	r.	PROPN
biomedich-119	165	37	and	and	CCONJ
biomedich-119	165	38	hering	hering	PROPN
biomedich-119	165	39	,	,	PUNCT
biomedich-119	165	40	b.j	b.j	PROPN
biomedich-119	165	41	.	.	PROPN
biomedich-119	165	42	,	,	PUNCT
biomedich-119	165	43	2012	2012	NUM
biomedich-119	165	44	.	.	PUNCT
biomedich-119	166	1	potent	potent	ADJ
biomedich-119	166	2	induction	induction	NOUN
biomedich-119	166	3	immunotherapy	immunotherapy	NOUN
biomedich-119	166	4	promotes	promote	VERB
biomedich-119	166	5	long‐term	long‐term	NOUN
biomedich-119	166	6	insulin	insulin	NOUN
biomedich-119	166	7	independence	independence	NOUN
biomedich-119	166	8	after	after	ADP
biomedich-119	166	9	islet	islet	NOUN
biomedich-119	166	10	transplantation	transplantation	NOUN
biomedich-119	166	11	in	in	ADP
biomedich-119	166	12	type	type	NOUN
biomedich-119	166	13	1	1	NUM
biomedich-119	166	14	diabetes	diabetes	NOUN
biomedich-119	166	15	.	.	PUNCT
biomedich-119	167	1	american	american	ADJ
biomedich-119	167	2	journal	journal	PROPN
biomedich-119	167	3	of	of	ADP
biomedich-119	167	4	transplantation	transplantation	NOUN
biomedich-119	167	5	,	,	PUNCT
biomedich-119	167	6	12(6	12(6	NUM
biomedich-119	167	7	)	)	PUNCT
biomedich-119	167	8	,	,	PUNCT
biomedich-119	167	9	pp.1576	pp.1576	PROPN
biomedich-119	167	10	-	-	PUNCT
biomedich-119	167	11	1583	1583	NUM
biomedich-119	167	12	.	.	PUNCT
biomedich-119	168	1	black	black	ADJ
biomedich-119	168	2	,	,	PUNCT
biomedich-119	168	3	l.a	l.a	PROPN
biomedich-119	168	4	.	.	PROPN
biomedich-119	168	5	and	and	CCONJ
biomedich-119	168	6	zorina	zorina	PROPN
biomedich-119	168	7	,	,	PUNCT
biomedich-119	168	8	t.	t.	PROPN
biomedich-119	168	9	,	,	PUNCT
biomedich-119	168	10	2020	2020	NUM
biomedich-119	168	11	.	.	PUNCT
biomedich-119	169	1	genetic	genetic	ADJ
biomedich-119	169	2	profile	profile	NOUN
biomedich-119	169	3	considerations	consideration	NOUN
biomedich-119	169	4	for	for	ADP
biomedich-119	169	5	induction	induction	NOUN
biomedich-119	169	6	of	of	ADP
biomedich-119	169	7	allogeneic	allogeneic	ADJ
biomedich-119	169	8	chimerism	chimerism	NOUN
biomedich-119	169	9	as	as	ADP
biomedich-119	169	10	a	a	DET
biomedich-119	169	11	therapeutic	therapeutic	ADJ
biomedich-119	169	12	approach	approach	NOUN
biomedich-119	169	13	for	for	ADP
biomedich-119	169	14	type	type	NOUN
biomedich-119	169	15	1	1	NUM
biomedich-119	169	16	diabetes	diabetes	NOUN
biomedich-119	169	17	mellitus	mellitus	NOUN
biomedich-119	169	18	.	.	PUNCT
biomedich-119	170	1	drug	drug	NOUN
biomedich-119	170	2	discovery	discovery	PROPN
biomedich-119	170	3	today	today	NOUN
biomedich-119	170	4	.	.	PUNCT
biomedich-119	171	1	bonner	bonner	PROPN
biomedich-119	171	2	-	-	PUNCT
biomedich-119	171	3	weir	weir	PROPN
biomedich-119	171	4	,	,	PUNCT
biomedich-119	171	5	s.	s.	PROPN
biomedich-119	171	6	and	and	CCONJ
biomedich-119	171	7	weir	weir	PROPN
biomedich-119	171	8	,	,	PUNCT
biomedich-119	171	9	g.c	g.c	PROPN
biomedich-119	171	10	.	.	PROPN
biomedich-119	171	11	,	,	PUNCT
biomedich-119	171	12	2005	2005	NUM
biomedich-119	171	13	.	.	PUNCT
biomedich-119	172	1	new	new	ADJ
biomedich-119	172	2	sources	source	NOUN
biomedich-119	172	3	of	of	ADP
biomedich-119	172	4	pancreatic	pancreatic	ADJ
biomedich-119	172	5	β	β	NOUN
biomedich-119	172	6	-	-	NOUN
biomedich-119	172	7	cells	cell	NOUN
biomedich-119	172	8	.	.	PUNCT
biomedich-119	173	1	nature	nature	NOUN
biomedich-119	173	2	biotechnology	biotechnology	NOUN
biomedich-119	173	3	,	,	PUNCT
biomedich-119	173	4	23(7	23(7	NUM
biomedich-119	173	5	)	)	PUNCT
biomedich-119	173	6	,	,	PUNCT
biomedich-119	173	7	pp.857	pp.857	PROPN
biomedich-119	173	8	-	-	PUNCT
biomedich-119	173	9	861	861	NUM
biomedich-119	173	10	.	.	PUNCT
biomedich-119	174	1	borkar	borkar	PROPN
biomedich-119	174	2	,	,	PUNCT
biomedich-119	174	3	s.s	s.s	PROPN
biomedich-119	174	4	.	.	PROPN
biomedich-119	174	5	,	,	PUNCT
biomedich-119	174	6	wakodkar	wakodkar	PROPN
biomedich-119	174	7	,	,	PUNCT
biomedich-119	174	8	s.b	s.b	PROPN
biomedich-119	174	9	.	.	PROPN
biomedich-119	174	10	,	,	PUNCT
biomedich-119	174	11	raghatate	raghatate	NOUN
biomedich-119	174	12	,	,	PUNCT
biomedich-119	174	13	p.s	p.s	PROPN
biomedich-119	174	14	.	.	PROPN
biomedich-119	174	15	and	and	CCONJ
biomedich-119	174	16	mahapatra	mahapatra	PROPN
biomedich-119	174	17	,	,	PUNCT
biomedich-119	174	18	d.k	d.k	PROPN
biomedich-119	174	19	.	.	PROPN
biomedich-119	174	20	,	,	PUNCT
biomedich-119	174	21	gene	gene	NOUN
biomedich-119	174	22	therapy	therapy	NOUN
biomedich-119	174	23	:	:	PUNCT
biomedich-119	174	24	new	new	ADJ
biomedich-119	174	25	therapeutic	therapeutic	ADJ
biomedich-119	174	26	approach	approach	NOUN
biomedich-119	174	27	to	to	ADP
biomedich-119	174	28	diabetes	diabetes	NOUN
biomedich-119	174	29	mellitus	mellitus	NOUN
biomedich-119	174	30	.	.	PUNCT
biomedich-119	175	1	gene	gene	NOUN
biomedich-119	175	2	,	,	PUNCT
biomedich-119	175	3	1	1	NUM
biomedich-119	175	4	,	,	PUNCT
biomedich-119	175	5	p.9	p.9	NOUN
biomedich-119	175	6	.	.	PUNCT
biomedich-119	176	1	bosi	bosi	NOUN
biomedich-119	176	2	,	,	PUNCT
biomedich-119	176	3	e.	e.	PROPN
biomedich-119	176	4	,	,	PUNCT
biomedich-119	176	5	braghi	braghi	PROPN
biomedich-119	176	6	,	,	PUNCT
biomedich-119	176	7	s.	s.	PROPN
biomedich-119	176	8	,	,	PUNCT
biomedich-119	176	9	maffi	maffi	ADV
biomedich-119	176	10	,	,	PUNCT
biomedich-119	176	11	p.	p.	NOUN
biomedich-119	176	12	,	,	PUNCT
biomedich-119	176	13	scirpoli	scirpoli	PROPN
biomedich-119	176	14	,	,	PUNCT
biomedich-119	176	15	m.	m.	NOUN
biomedich-119	176	16	,	,	PUNCT
biomedich-119	176	17	bertuzzi	bertuzzi	PROPN
biomedich-119	176	18	,	,	PUNCT
biomedich-119	176	19	f.	f.	PROPN
biomedich-119	176	20	,	,	PUNCT
biomedich-119	176	21	pozza	pozza	PROPN
biomedich-119	176	22	,	,	PUNCT
biomedich-119	176	23	g.	g.	PROPN
biomedich-119	176	24	,	,	PUNCT
biomedich-119	176	25	secchi	secchi	PROPN
biomedich-119	176	26	,	,	PUNCT
biomedich-119	176	27	a.	a.	NOUN
biomedich-119	176	28	and	and	CCONJ
biomedich-119	176	29	bonifacio	bonifacio	PROPN
biomedich-119	176	30	,	,	PUNCT
biomedich-119	176	31	e.	e.	PROPN
biomedich-119	176	32	,	,	PUNCT
biomedich-119	176	33	2001	2001	NUM
biomedich-119	176	34	.	.	PUNCT
biomedich-119	177	1	autoantibody	autoantibody	ADJ
biomedich-119	177	2	response	response	NOUN
biomedich-119	177	3	to	to	ADP
biomedich-119	177	4	islet	islet	NOUN
biomedich-119	177	5	transplantation	transplantation	NOUN
biomedich-119	177	6	in	in	ADP
biomedich-119	177	7	type	type	NOUN
biomedich-119	177	8	1	1	NUM
biomedich-119	177	9	diabetes	diabetes	NOUN
biomedich-119	177	10	.	.	PUNCT
biomedich-119	178	1	diabetes	diabetes	NOUN
biomedich-119	178	2	,	,	PUNCT
biomedich-119	178	3	50(11	50(11	NUM
biomedich-119	178	4	)	)	PUNCT
biomedich-119	178	5	,	,	PUNCT
biomedich-119	178	6	pp.2464	pp.2464	PROPN
biomedich-119	178	7	-	-	PUNCT
biomedich-119	178	8	2471	2471	NUM
biomedich-119	178	9	.	.	PUNCT
biomedich-119	179	1	brandon	brandon	PROPN
biomedich-119	179	2	,	,	PUNCT
biomedich-119	179	3	e.p	e.p	PROPN
biomedich-119	179	4	.	.	PROPN
biomedich-119	179	5	,	,	PUNCT
biomedich-119	179	6	scott	scott	PROPN
biomedich-119	179	7	,	,	PUNCT
biomedich-119	179	8	m.j	m.j	PROPN
biomedich-119	179	9	.	.	PROPN
biomedich-119	179	10	,	,	PUNCT
biomedich-119	179	11	zimmerman	zimmerman	PROPN
biomedich-119	179	12	,	,	PUNCT
biomedich-119	179	13	m.c	m.c	PROPN
biomedich-119	179	14	.	.	PROPN
biomedich-119	179	15	and	and	CCONJ
biomedich-119	179	16	d’amour	d’amour	PROPN
biomedich-119	179	17	,	,	PUNCT
biomedich-119	179	18	k.a	k.a	PROPN
biomedich-119	179	19	.	.	PROPN
biomedich-119	179	20	,	,	PUNCT
biomedich-119	179	21	2020	2020	NUM
biomedich-119	179	22	.	.	PUNCT
biomedich-119	180	1	pluripotent	pluripotent	ADJ
biomedich-119	180	2	stem	stem	NOUN
biomedich-119	180	3	cell	cell	NOUN
biomedich-119	180	4	–	–	PUNCT
biomedich-119	180	5	derived	derive	VERB
biomedich-119	180	6	islet	islet	NOUN
biomedich-119	180	7	replacement	replacement	NOUN
biomedich-119	180	8	therapy	therapy	NOUN
biomedich-119	180	9	for	for	ADP
biomedich-119	180	10	diabetes	diabetes	NOUN
biomedich-119	180	11	.	.	PUNCT
biomedich-119	181	1	in	in	ADP
biomedich-119	181	2	second	second	ADJ
biomedich-119	181	3	generation	generation	NOUN
biomedich-119	181	4	cell	cell	NOUN
biomedich-119	181	5	and	and	CCONJ
biomedich-119	181	6	genebased	genebase	VERB
biomedich-119	181	7	therapies	therapy	NOUN
biomedich-119	181	8	(	(	PUNCT
biomedich-119	181	9	pp	pp	ADJ
biomedich-119	181	10	.	.	PUNCT
biomedich-119	181	11	157	157	NUM
biomedich-119	181	12	-	-	SYM
biomedich-119	181	13	181	181	NUM
biomedich-119	181	14	)	)	PUNCT
biomedich-119	181	15	.	.	PUNCT
biomedich-119	182	1	academic	academic	ADJ
biomedich-119	182	2	press	press	NOUN
biomedich-119	182	3	.	.	PUNCT
biomedich-119	183	1	bruni	bruni	PROPN
biomedich-119	183	2	,	,	PUNCT
biomedich-119	183	3	a.	a.	NOUN
biomedich-119	183	4	,	,	PUNCT
biomedich-119	183	5	gala	gala	NOUN
biomedich-119	183	6	-	-	PUNCT
biomedich-119	183	7	lopez	lopez	NOUN
biomedich-119	183	8	,	,	PUNCT
biomedich-119	183	9	b.	b.	PROPN
biomedich-119	183	10	,	,	PUNCT
biomedich-119	183	11	pepper	pepper	NOUN
biomedich-119	183	12	,	,	PUNCT
biomedich-119	183	13	a.r	a.r	PROPN
biomedich-119	183	14	.	.	PROPN
biomedich-119	183	15	,	,	PUNCT
biomedich-119	183	16	abualhassan	abualhassan	PROPN
biomedich-119	183	17	,	,	PUNCT
biomedich-119	183	18	n.s	n.s	PROPN
biomedich-119	183	19	.	.	PROPN
biomedich-119	183	20	and	and	CCONJ
biomedich-119	183	21	shapiro	shapiro	PROPN
biomedich-119	183	22	,	,	PUNCT
biomedich-119	183	23	a.j	a.j	PROPN
biomedich-119	183	24	.	.	PROPN
biomedich-119	183	25	,	,	PUNCT
biomedich-119	183	26	2014	2014	NUM
biomedich-119	183	27	.	.	PUNCT
biomedich-119	184	1	islet	islet	NOUN
biomedich-119	184	2	cell	cell	NOUN
biomedich-119	184	3	transplantation	transplantation	NOUN
biomedich-119	184	4	for	for	ADP
biomedich-119	184	5	the	the	DET
biomedich-119	184	6	treatment	treatment	NOUN
biomedich-119	184	7	of	of	ADP
biomedich-119	184	8	type	type	NOUN
biomedich-119	184	9	1	1	NUM
biomedich-119	184	10	diabetes	diabete	NOUN
biomedich-119	184	11	:	:	PUNCT
biomedich-119	184	12	recent	recent	ADJ
biomedich-119	184	13	advances	advance	NOUN
biomedich-119	184	14	and	and	CCONJ
biomedich-119	184	15	future	future	ADJ
biomedich-119	184	16	challenges	challenge	NOUN
biomedich-119	184	17	.	.	PUNCT
biomedich-119	185	1	diabetes	diabetes	NOUN
biomedich-119	185	2	,	,	PUNCT
biomedich-119	185	3	metabolic	metabolic	NOUN
biomedich-119	185	4	syndrome	syndrome	NOUN
biomedich-119	185	5	and	and	CCONJ
biomedich-119	185	6	obesity	obesity	NOUN
biomedich-119	185	7	:	:	PUNCT
biomedich-119	185	8	targets	target	NOUN
biomedich-119	185	9	and	and	CCONJ
biomedich-119	185	10	therapy	therapy	NOUN
biomedich-119	185	11	,	,	PUNCT
biomedich-119	185	12	7	7	NUM
biomedich-119	185	13	,	,	PUNCT
biomedich-119	185	14	p.211	p.211	X
biomedich-119	185	15	.	.	PUNCT
biomedich-119	186	1	chen	chen	PROPN
biomedich-119	186	2	,	,	PUNCT
biomedich-119	186	3	r.	r.	PROPN
biomedich-119	186	4	,	,	PUNCT
biomedich-119	186	5	meseck	meseck	PROPN
biomedich-119	186	6	,	,	PUNCT
biomedich-119	186	7	m.l	m.l	PROPN
biomedich-119	186	8	.	.	PROPN
biomedich-119	186	9	and	and	CCONJ
biomedich-119	186	10	woo	woo	PROPN
biomedich-119	186	11	,	,	PUNCT
biomedich-119	186	12	s.l	s.l	PROPN
biomedich-119	186	13	.	.	PROPN
biomedich-119	186	14	,	,	PUNCT
biomedich-119	186	15	2001	2001	NUM
biomedich-119	186	16	.	.	PUNCT
biomedich-119	187	1	auto	auto	NOUN
biomedich-119	187	2	-	-	PUNCT
biomedich-119	187	3	regulated	regulate	VERB
biomedich-119	187	4	hepatic	hepatic	ADJ
biomedich-119	187	5	insulin	insulin	NOUN
biomedich-119	187	6	gene	gene	NOUN
biomedich-119	187	7	expression	expression	NOUN
biomedich-119	187	8	in	in	ADP
biomedich-119	187	9	type	type	NOUN
biomedich-119	187	10	1	1	NUM
biomedich-119	187	11	diabetic	diabetic	ADJ
biomedich-119	187	12	rats	rat	NOUN
biomedich-119	187	13	.	.	PUNCT
biomedich-119	188	1	molecular	molecular	ADJ
biomedich-119	188	2	therapy	therapy	NOUN
biomedich-119	188	3	,	,	PUNCT
biomedich-119	188	4	3(4	3(4	NUM
biomedich-119	188	5	)	)	PUNCT
biomedich-119	188	6	,	,	PUNCT
biomedich-119	188	7	pp.584	pp.584	PROPN
biomedich-119	188	8	-	-	PUNCT
biomedich-119	188	9	590	590	NUM
biomedich-119	188	10	.	.	PUNCT
biomedich-119	189	1	cieluch	cieluch	ADJ
biomedich-119	189	2	,	,	PUNCT
biomedich-119	189	3	a.	a.	NOUN
biomedich-119	189	4	,	,	PUNCT
biomedich-119	189	5	uruska	uruska	NOUN
biomedich-119	189	6	,	,	PUNCT
biomedich-119	189	7	a.	a.	NOUN
biomedich-119	189	8	and	and	CCONJ
biomedich-119	189	9	zozulinska	zozulinska	PROPN
biomedich-119	189	10	-	-	PUNCT
biomedich-119	189	11	ziolkiewicz	ziolkiewicz	NOUN
biomedich-119	189	12	,	,	PUNCT
biomedich-119	189	13	d.	d.	PROPN
biomedich-119	189	14	,	,	PUNCT
biomedich-119	189	15	2020	2020	NUM
biomedich-119	189	16	.	.	PUNCT
biomedich-119	190	1	can	can	AUX
biomedich-119	190	2	we	we	PRON
biomedich-119	190	3	prevent	prevent	VERB
biomedich-119	190	4	mitochondrial	mitochondrial	ADJ
biomedich-119	190	5	dysfunction	dysfunction	NOUN
biomedich-119	190	6	and	and	CCONJ
biomedich-119	190	7	diabetic	diabetic	ADJ
biomedich-119	190	8	cardiomyopathy	cardiomyopathy	ADJ
biomedich-119	190	9	in	in	ADP
biomedich-119	190	10	type	type	NOUN
biomedich-119	190	11	1	1	NUM
biomedich-119	190	12	diabetes	diabetes	NOUN
biomedich-119	190	13	mellitus	mellitus	NOUN
biomedich-119	190	14	?	?	PUNCT
biomedich-119	191	1	pathophysiology	pathophysiology	NOUN
biomedich-119	191	2	and	and	CCONJ
biomedich-119	191	3	treatment	treatment	NOUN
biomedich-119	191	4	options	option	NOUN
biomedich-119	191	5	.	.	PUNCT
biomedich-119	192	1	international	international	ADJ
biomedich-119	192	2	journal	journal	NOUN
biomedich-119	192	3	of	of	ADP
biomedich-119	192	4	molecular	molecular	ADJ
biomedich-119	192	5	sciences	science	NOUN
biomedich-119	192	6	,	,	PUNCT
biomedich-119	192	7	21(8	21(8	NUM
biomedich-119	192	8	)	)	PUNCT
biomedich-119	192	9	,	,	PUNCT
biomedich-119	192	10	p.2852	p.2852	NOUN
biomedich-119	192	11	.	.	PUNCT
biomedich-119	193	1	cobo	cobo	PROPN
biomedich-119	193	2	-	-	PUNCT
biomedich-119	193	3	vuilleumier	vuilleumier	PROPN
biomedich-119	193	4	,	,	PUNCT
biomedich-119	193	5	n.	n.	NOUN
biomedich-119	193	6	and	and	CCONJ
biomedich-119	193	7	gauthier	gauthier	PROPN
biomedich-119	193	8	,	,	PUNCT
biomedich-119	193	9	b.r	b.r	PROPN
biomedich-119	193	10	.	.	PROPN
biomedich-119	193	11	,	,	PUNCT
biomedich-119	193	12	2020	2020	NUM
biomedich-119	193	13	.	.	PUNCT
biomedich-119	194	1	time	time	NOUN
biomedich-119	194	2	for	for	ADP
biomedich-119	194	3	a	a	DET
biomedich-119	194	4	paradigm	paradigm	NOUN
biomedich-119	194	5	shift	shift	NOUN
biomedich-119	194	6	in	in	ADP
biomedich-119	194	7	treating	treat	VERB
biomedich-119	194	8	type	type	NOUN
biomedich-119	194	9	1	1	NUM
biomedich-119	194	10	diabetes	diabetes	NOUN
biomedich-119	194	11	mellitus	mellitus	NOUN
biomedich-119	194	12	:	:	PUNCT
biomedich-119	194	13	coupling	couple	VERB
biomedich-119	194	14	inflammation	inflammation	NOUN
biomedich-119	194	15	to	to	PART
biomedich-119	194	16	islet	islet	NOUN
biomedich-119	194	17	regeneration	regeneration	NOUN
biomedich-119	194	18	.	.	PUNCT
biomedich-119	195	1	metabolism	metabolism	NOUN
biomedich-119	195	2	,	,	PUNCT
biomedich-119	195	3	104	104	NUM
biomedich-119	195	4	,	,	PUNCT
biomedich-119	195	5	p.154137	p.154137	X
biomedich-119	195	6	.	.	PUNCT
biomedich-119	196	1	de	de	PROPN
biomedich-119	196	2	haan	haan	PROPN
biomedich-119	196	3	,	,	PUNCT
biomedich-119	196	4	p.	p.	PROPN
biomedich-119	196	5	,	,	PUNCT
biomedich-119	196	6	van	van	PROPN
biomedich-119	196	7	diemen	dieman	NOUN
biomedich-119	196	8	,	,	PUNCT
biomedich-119	196	9	f.r	f.r	PROPN
biomedich-119	196	10	.	.	PROPN
biomedich-119	196	11	and	and	CCONJ
biomedich-119	196	12	toscano	toscano	PROPN
biomedich-119	196	13	,	,	PUNCT
biomedich-119	196	14	m.g	m.g	PROPN
biomedich-119	196	15	.	.	PROPN
biomedich-119	196	16	,	,	PUNCT
biomedich-119	196	17	2020	2020	NUM
biomedich-119	196	18	.	.	PUNCT
biomedich-119	197	1	viral	viral	ADJ
biomedich-119	197	2	gene	gene	NOUN
biomedich-119	197	3	delivery	delivery	NOUN
biomedich-119	197	4	vectors	vector	NOUN
biomedich-119	197	5	:	:	PUNCT
biomedich-119	197	6	the	the	DET
biomedich-119	197	7	next	next	ADJ
biomedich-119	197	8	generation	generation	NOUN
biomedich-119	197	9	medicines	medicine	NOUN
biomedich-119	197	10	for	for	ADP
biomedich-119	197	11	immune	immune	NOUN
biomedich-119	197	12	-	-	PUNCT
biomedich-119	197	13	related	relate	VERB
biomedich-119	197	14	diseases	disease	NOUN
biomedich-119	197	15	.	.	PUNCT
biomedich-119	198	1	human	human	ADJ
biomedich-119	198	2	vaccines	vaccine	NOUN
biomedich-119	198	3	&	&	CCONJ
biomedich-119	198	4	immunotherapeutics	immunotherapeutic	NOUN
biomedich-119	198	5	,	,	PUNCT
biomedich-119	198	6	pp.1	pp.1	NOUN
biomedich-119	198	7	-	-	PUNCT
biomedich-119	198	8	8	8	NUM
biomedich-119	198	9	.	.	PUNCT
biomedich-119	198	10	de	de	X
biomedich-119	198	11	jesus	jesus	PROPN
biomedich-119	198	12	,	,	PUNCT
biomedich-119	198	13	d.f	d.f	PROPN
biomedich-119	198	14	.	.	PROPN
biomedich-119	198	15	and	and	CCONJ
biomedich-119	198	16	kulkarni	kulkarni	PROPN
biomedich-119	198	17	,	,	PUNCT
biomedich-119	198	18	r.n	r.n	PROPN
biomedich-119	198	19	.	.	PROPN
biomedich-119	198	20	,	,	PUNCT
biomedich-119	198	21	2020	2020	NUM
biomedich-119	198	22	.	.	PUNCT
biomedich-119	199	1	more	more	ADJ
biomedich-119	199	2	is	be	AUX
biomedich-119	199	3	better	well	ADJ
biomedich-119	199	4	:	:	PUNCT
biomedich-119	199	5	combinatorial	combinatorial	ADJ
biomedich-119	199	6	therapy	therapy	NOUN
biomedich-119	199	7	to	to	PART
biomedich-119	199	8	restore	restore	VERB
biomedich-119	199	9	β	β	NOUN
biomedich-119	199	10	-	-	ADJ
biomedich-119	199	11	cell	cell	NOUN
biomedich-119	199	12	function	function	NOUN
biomedich-119	199	13	in	in	ADP
biomedich-119	199	14	diabetes	diabetes	NOUN
biomedich-119	199	15	.	.	PUNCT
biomedich-119	200	1	nature	nature	NOUN
biomedich-119	200	2	metabolism	metabolism	NOUN
biomedich-119	200	3	,	,	PUNCT
biomedich-119	200	4	2(2	2(2	NUM
biomedich-119	200	5	)	)	PUNCT
biomedich-119	200	6	,	,	PUNCT
biomedich-119	200	7	pp.130	pp.130	NOUN
biomedich-119	200	8	-	-	PUNCT
biomedich-119	200	9	131	131	NUM
biomedich-119	200	10	.	.	PUNCT
biomedich-119	201	1	62	62	NUM
biomedich-119	201	2	biology	biology	NOUN
biomedich-119	201	3	,	,	PUNCT
biomedich-119	201	4	medicine	medicine	NOUN
biomedich-119	201	5	,	,	PUNCT
biomedich-119	201	6	&	&	CCONJ
biomedich-119	201	7	natural	natural	ADJ
biomedich-119	201	8	product	product	NOUN
biomedich-119	201	9	chemistry	chemistry	NOUN
biomedich-119	201	10	9	9	NUM
biomedich-119	201	11	(	(	PUNCT
biomedich-119	201	12	2	2	NUM
biomedich-119	201	13	)	)	PUNCT
biomedich-119	201	14	,	,	PUNCT
biomedich-119	201	15	2020	2020	NUM
biomedich-119	201	16	:	:	PUNCT
biomedich-119	201	17	57	57	NUM
biomedich-119	201	18	-	-	SYM
biomedich-119	201	19	64	64	NUM
biomedich-119	201	20	de	de	X
biomedich-119	201	21	kort	kort	PROPN
biomedich-119	201	22	,	,	PUNCT
biomedich-119	201	23	h.	h.	PROPN
biomedich-119	201	24	,	,	PUNCT
biomedich-119	201	25	de	de	PROPN
biomedich-119	201	26	koning	koning	PROPN
biomedich-119	201	27	,	,	PUNCT
biomedich-119	201	28	e.j	e.j	PROPN
biomedich-119	201	29	.	.	PROPN
biomedich-119	201	30	,	,	PUNCT
biomedich-119	201	31	rabelink	rabelink	PROPN
biomedich-119	201	32	,	,	PUNCT
biomedich-119	201	33	t.j	t.j	PROPN
biomedich-119	201	34	.	.	PROPN
biomedich-119	201	35	,	,	PUNCT
biomedich-119	201	36	bruijn	bruijn	PROPN
biomedich-119	201	37	,	,	PUNCT
biomedich-119	201	38	j.a	j.a	PROPN
biomedich-119	201	39	.	.	PROPN
biomedich-119	201	40	and	and	CCONJ
biomedich-119	201	41	bajema	bajema	PROPN
biomedich-119	201	42	,	,	PUNCT
biomedich-119	201	43	i.m	i.m	PROPN
biomedich-119	201	44	.	.	PROPN
biomedich-119	201	45	,	,	PUNCT
biomedich-119	201	46	2011	2011	NUM
biomedich-119	201	47	.	.	PUNCT
biomedich-119	202	1	islet	islet	NOUN
biomedich-119	202	2	transplantation	transplantation	NOUN
biomedich-119	202	3	in	in	ADP
biomedich-119	202	4	type	type	NOUN
biomedich-119	202	5	1	1	NUM
biomedich-119	202	6	diabetes	diabetes	NOUN
biomedich-119	202	7	.	.	PUNCT
biomedich-119	203	1	bmj	bmj	PROPN
biomedich-119	203	2	,	,	PUNCT
biomedich-119	203	3	342	342	NUM
biomedich-119	203	4	.	.	PUNCT
biomedich-119	204	1	desai	desai	PROPN
biomedich-119	204	2	,	,	PUNCT
biomedich-119	204	3	s.	s.	PROPN
biomedich-119	204	4	and	and	CCONJ
biomedich-119	204	5	deshmukh	deshmukh	PROPN
biomedich-119	204	6	,	,	PUNCT
biomedich-119	204	7	a.	a.	NOUN
biomedich-119	204	8	,	,	PUNCT
biomedich-119	204	9	2020	2020	NUM
biomedich-119	204	10	.	.	PUNCT
biomedich-119	205	1	mapping	mapping	NOUN
biomedich-119	205	2	of	of	ADP
biomedich-119	205	3	type	type	NOUN
biomedich-119	205	4	1	1	NUM
biomedich-119	205	5	diabetes	diabetes	NOUN
biomedich-119	205	6	mellitus	mellitus	NOUN
biomedich-119	205	7	.	.	PUNCT
biomedich-119	206	1	current	current	ADJ
biomedich-119	206	2	diabetes	diabetes	NOUN
biomedich-119	206	3	reviews	review	NOUN
biomedich-119	206	4	,	,	PUNCT
biomedich-119	206	5	16(5	16(5	NUM
biomedich-119	206	6	)	)	PUNCT
biomedich-119	206	7	,	,	PUNCT
biomedich-119	206	8	pp.438	pp.438	PROPN
biomedich-119	206	9	-	-	PUNCT
biomedich-119	206	10	441	441	NUM
biomedich-119	206	11	.	.	PUNCT
biomedich-119	207	1	donner	donner	PROPN
biomedich-119	207	2	,	,	PUNCT
biomedich-119	207	3	t.	t.	PROPN
biomedich-119	207	4	and	and	CCONJ
biomedich-119	207	5	sarkar	sarkar	PROPN
biomedich-119	207	6	,	,	PUNCT
biomedich-119	207	7	s.	s.	PROPN
biomedich-119	207	8	,	,	PUNCT
biomedich-119	207	9	2019	2019	NUM
biomedich-119	207	10	.	.	PUNCT
biomedich-119	208	1	insulin	insulin	NOUN
biomedich-119	208	2	–	–	PUNCT
biomedich-119	208	3	pharmacology	pharmacology	NOUN
biomedich-119	208	4	,	,	PUNCT
biomedich-119	208	5	therapeutic	therapeutic	ADJ
biomedich-119	208	6	regimens	regimen	NOUN
biomedich-119	208	7	,	,	PUNCT
biomedich-119	208	8	and	and	CCONJ
biomedich-119	208	9	principles	principle	NOUN
biomedich-119	208	10	of	of	ADP
biomedich-119	208	11	intensive	intensive	ADJ
biomedich-119	208	12	insulin	insulin	NOUN
biomedich-119	208	13	therapy	therapy	NOUN
biomedich-119	208	14	.	.	PUNCT
biomedich-119	209	1	in	in	ADP
biomedich-119	209	2	endotext	endotext	NOUN
biomedich-119	209	3	[	[	X
biomedich-119	209	4	internet	internet	NOUN
biomedich-119	209	5	]	]	PUNCT
biomedich-119	209	6	.	.	PUNCT
biomedich-119	210	1	mdtext	mdtext	PROPN
biomedich-119	210	2	.	.	PUNCT
biomedich-119	210	3	com	com	PROPN
biomedich-119	210	4	,	,	PUNCT
biomedich-119	210	5	inc	inc	PROPN
biomedich-119	210	6	.	.	PROPN
biomedich-119	210	7	dunbar	dunbar	PROPN
biomedich-119	210	8	,	,	PUNCT
biomedich-119	210	9	c.e	c.e	PROPN
biomedich-119	210	10	.	.	PROPN
biomedich-119	210	11	,	,	PUNCT
biomedich-119	210	12	high	high	ADJ
biomedich-119	210	13	,	,	PUNCT
biomedich-119	210	14	k.a	k.a	PROPN
biomedich-119	210	15	.	.	PROPN
biomedich-119	210	16	,	,	PUNCT
biomedich-119	210	17	joung	joung	PROPN
biomedich-119	210	18	,	,	PUNCT
biomedich-119	210	19	j.k	j.k	PROPN
biomedich-119	210	20	.	.	PROPN
biomedich-119	210	21	,	,	PUNCT
biomedich-119	210	22	kohn	kohn	PROPN
biomedich-119	210	23	,	,	PUNCT
biomedich-119	210	24	d.b	d.b	PROPN
biomedich-119	210	25	.	.	PROPN
biomedich-119	210	26	,	,	PUNCT
biomedich-119	210	27	ozawa	ozawa	PROPN
biomedich-119	210	28	,	,	PUNCT
biomedich-119	210	29	k.	k.	PROPN
biomedich-119	210	30	and	and	CCONJ
biomedich-119	210	31	sadelain	sadelain	PROPN
biomedich-119	210	32	,	,	PUNCT
biomedich-119	210	33	m.	m.	NOUN
biomedich-119	210	34	,	,	PUNCT
biomedich-119	210	35	2018	2018	NUM
biomedich-119	210	36	.	.	PUNCT
biomedich-119	211	1	gene	gene	NOUN
biomedich-119	211	2	therapy	therapy	NOUN
biomedich-119	211	3	comes	come	VERB
biomedich-119	211	4	of	of	ADP
biomedich-119	211	5	age	age	NOUN
biomedich-119	211	6	.	.	PUNCT
biomedich-119	212	1	science	science	NOUN
biomedich-119	212	2	,	,	PUNCT
biomedich-119	212	3	359(6372	359(6372	NUM
biomedich-119	212	4	)	)	PUNCT
biomedich-119	212	5	.	.	PUNCT
biomedich-119	213	1	emerich	emerich	PROPN
biomedich-119	213	2	,	,	PUNCT
biomedich-119	213	3	d.f	d.f	PROPN
biomedich-119	213	4	.	.	PROPN
biomedich-119	213	5	,	,	PUNCT
biomedich-119	213	6	2002	2002	NUM
biomedich-119	213	7	.	.	PUNCT
biomedich-119	214	1	islet	islet	NOUN
biomedich-119	214	2	transplantation	transplantation	NOUN
biomedich-119	214	3	for	for	ADP
biomedich-119	214	4	diabetes	diabetes	NOUN
biomedich-119	214	5	:	:	PUNCT
biomedich-119	214	6	current	current	ADJ
biomedich-119	214	7	status	status	NOUN
biomedich-119	214	8	and	and	CCONJ
biomedich-119	214	9	future	future	ADJ
biomedich-119	214	10	prospects	prospect	NOUN
biomedich-119	214	11	.	.	PUNCT
biomedich-119	215	1	expert	expert	ADJ
biomedich-119	215	2	opinion	opinion	NOUN
biomedich-119	215	3	on	on	ADP
biomedich-119	215	4	biological	biological	ADJ
biomedich-119	215	5	therapy	therapy	NOUN
biomedich-119	215	6	,	,	PUNCT
biomedich-119	215	7	2(8	2(8	NUM
biomedich-119	215	8	)	)	PUNCT
biomedich-119	215	9	,	,	PUNCT
biomedich-119	215	10	pp.793	pp.793	NOUN
biomedich-119	215	11	-	-	PUNCT
biomedich-119	215	12	803	803	NUM
biomedich-119	215	13	.	.	PUNCT
biomedich-119	216	1	escors	escor	NOUN
biomedich-119	216	2	,	,	PUNCT
biomedich-119	216	3	d.	d.	NOUN
biomedich-119	216	4	and	and	CCONJ
biomedich-119	216	5	breckpot	breckpot	PROPN
biomedich-119	216	6	,	,	PUNCT
biomedich-119	216	7	k.	k.	PROPN
biomedich-119	216	8	,	,	PUNCT
biomedich-119	216	9	2010	2010	NUM
biomedich-119	216	10	.	.	PUNCT
biomedich-119	217	1	lentiviral	lentiviral	ADJ
biomedich-119	217	2	vectors	vector	NOUN
biomedich-119	217	3	in	in	ADP
biomedich-119	217	4	gene	gene	NOUN
biomedich-119	217	5	therapy	therapy	NOUN
biomedich-119	217	6	:	:	PUNCT
biomedich-119	217	7	their	their	PRON
biomedich-119	217	8	current	current	ADJ
biomedich-119	217	9	status	status	NOUN
biomedich-119	217	10	and	and	CCONJ
biomedich-119	217	11	future	future	ADJ
biomedich-119	217	12	potential	potential	NOUN
biomedich-119	217	13	.	.	PUNCT
biomedich-119	218	1	archivum	archivum	PROPN
biomedich-119	218	2	immunologiae	immunologiae	ADJ
biomedich-119	218	3	et	et	PROPN
biomedich-119	218	4	therapiae	therapiae	NOUN
biomedich-119	218	5	experimentalis	experimentali	NOUN
biomedich-119	218	6	,	,	PUNCT
biomedich-119	218	7	58(2	58(2	NUM
biomedich-119	218	8	)	)	PUNCT
biomedich-119	218	9	,	,	PUNCT
biomedich-119	218	10	pp.107	pp.107	PROPN
biomedich-119	218	11	-	-	SYM
biomedich-119	218	12	119	119	NUM
biomedich-119	218	13	.	.	PUNCT
biomedich-119	219	1	fang	fang	PROPN
biomedich-119	219	2	,	,	PUNCT
biomedich-119	219	3	q.	q.	PROPN
biomedich-119	219	4	,	,	PUNCT
biomedich-119	219	5	zhai	zhai	PROPN
biomedich-119	219	6	,	,	PUNCT
biomedich-119	219	7	m.	m.	NOUN
biomedich-119	219	8	,	,	PUNCT
biomedich-119	219	9	wu	wu	PROPN
biomedich-119	219	10	,	,	PUNCT
biomedich-119	219	11	s.	s.	PROPN
biomedich-119	219	12	,	,	PUNCT
biomedich-119	219	13	hu	hu	PROPN
biomedich-119	219	14	,	,	PUNCT
biomedich-119	219	15	x.	x.	PROPN
biomedich-119	219	16	,	,	PUNCT
biomedich-119	219	17	hua	hua	PROPN
biomedich-119	219	18	,	,	PUNCT
biomedich-119	219	19	z.	z.	PROPN
biomedich-119	219	20	,	,	PUNCT
biomedich-119	219	21	sun	sun	PROPN
biomedich-119	219	22	,	,	PUNCT
biomedich-119	219	23	h.	h.	PROPN
biomedich-119	219	24	,	,	PUNCT
biomedich-119	219	25	guo	guo	PROPN
biomedich-119	219	26	,	,	PUNCT
biomedich-119	219	27	j.	j.	PROPN
biomedich-119	219	28	,	,	PUNCT
biomedich-119	219	29	zhang	zhang	PROPN
biomedich-119	219	30	,	,	PUNCT
biomedich-119	219	31	w.	w.	PROPN
biomedich-119	219	32	and	and	CCONJ
biomedich-119	219	33	wang	wang	PROPN
biomedich-119	219	34	,	,	PUNCT
biomedich-119	219	35	z.	z.	PROPN
biomedich-119	219	36	,	,	PUNCT
biomedich-119	219	37	2019	2019	NUM
biomedich-119	219	38	.	.	PUNCT
biomedich-119	220	1	adipocyte	adipocyte	NOUN
biomedich-119	220	2	-	-	PUNCT
biomedich-119	220	3	derived	derive	VERB
biomedich-119	220	4	stem	stem	NOUN
biomedich-119	220	5	cellbased	cellbase	VERB
biomedich-119	220	6	gene	gene	NOUN
biomedich-119	220	7	therapy	therapy	NOUN
biomedich-119	220	8	upon	upon	SCONJ
biomedich-119	220	9	adipogenic	adipogenic	ADJ
biomedich-119	220	10	differentiation	differentiation	NOUN
biomedich-119	220	11	on	on	ADP
biomedich-119	220	12	microcarriers	microcarrier	NOUN
biomedich-119	220	13	attenuates	attenuate	VERB
biomedich-119	220	14	type	type	NOUN
biomedich-119	220	15	1	1	NUM
biomedich-119	220	16	diabetes	diabetes	NOUN
biomedich-119	220	17	in	in	ADP
biomedich-119	220	18	mice	mouse	NOUN
biomedich-119	220	19	.	.	PUNCT
biomedich-119	221	1	stem	stem	NOUN
biomedich-119	221	2	cell	cell	NOUN
biomedich-119	221	3	research	research	NOUN
biomedich-119	221	4	&	&	CCONJ
biomedich-119	221	5	therapy	therapy	NOUN
biomedich-119	221	6	,	,	PUNCT
biomedich-119	221	7	10(1	10(1	NUM
biomedich-119	221	8	)	)	PUNCT
biomedich-119	221	9	,	,	PUNCT
biomedich-119	221	10	pp.1	pp.1	NOUN
biomedich-119	221	11	-	-	PUNCT
biomedich-119	221	12	11	11	NUM
biomedich-119	221	13	.	.	PUNCT
biomedich-119	222	1	farooq	farooq	PROPN
biomedich-119	222	2	,	,	PUNCT
biomedich-119	222	3	t.	t.	PROPN
biomedich-119	222	4	,	,	PUNCT
biomedich-119	222	5	rehman	rehman	PROPN
biomedich-119	222	6	,	,	PUNCT
biomedich-119	222	7	k.	k.	PROPN
biomedich-119	222	8	,	,	PUNCT
biomedich-119	222	9	hameed	hameed	PROPN
biomedich-119	222	10	,	,	PUNCT
biomedich-119	222	11	a.	a.	NOUN
biomedich-119	222	12	and	and	CCONJ
biomedich-119	222	13	akash	akash	PROPN
biomedich-119	222	14	,	,	PUNCT
biomedich-119	222	15	m.s.h	m.s.h	PROPN
biomedich-119	222	16	.	.	PROPN
biomedich-119	222	17	,	,	PUNCT
biomedich-119	222	18	2019	2019	NUM
biomedich-119	222	19	.	.	PUNCT
biomedich-119	223	1	stem	stem	NOUN
biomedich-119	223	2	cell	cell	NOUN
biomedich-119	223	3	therapy	therapy	NOUN
biomedich-119	223	4	and	and	CCONJ
biomedich-119	223	5	type	type	NOUN
biomedich-119	223	6	1	1	NUM
biomedich-119	223	7	diabetes	diabetes	NOUN
biomedich-119	223	8	mellitus	mellitus	NOUN
biomedich-119	223	9	:	:	PUNCT
biomedich-119	223	10	treatment	treatment	NOUN
biomedich-119	223	11	strategies	strategy	NOUN
biomedich-119	223	12	and	and	CCONJ
biomedich-119	223	13	future	future	ADJ
biomedich-119	223	14	perspectives	perspective	NOUN
biomedich-119	223	15	.	.	PUNCT
biomedich-119	224	1	in	in	ADP
biomedich-119	224	2	tissue	tissue	NOUN
biomedich-119	224	3	engineering	engineering	NOUN
biomedich-119	224	4	and	and	CCONJ
biomedich-119	224	5	regenerative	regenerative	ADJ
biomedich-119	224	6	medicine	medicine	NOUN
biomedich-119	224	7	(	(	PUNCT
biomedich-119	224	8	pp	pp	ADJ
biomedich-119	224	9	.	.	PUNCT
biomedich-119	224	10	95	95	NUM
biomedich-119	224	11	-	-	SYM
biomedich-119	224	12	107	107	NUM
biomedich-119	224	13	)	)	PUNCT
biomedich-119	224	14	.	.	PUNCT
biomedich-119	225	1	springer	springer	NOUN
biomedich-119	225	2	international	international	ADJ
biomedich-119	225	3	publishing	publishing	NOUN
biomedich-119	225	4	.	.	PUNCT
biomedich-119	226	1	friedmann	friedmann	PROPN
biomedich-119	226	2	,	,	PUNCT
biomedich-119	226	3	t.	t.	NOUN
biomedich-119	226	4	,	,	PUNCT
biomedich-119	226	5	1992	1992	NUM
biomedich-119	226	6	.	.	PUNCT
biomedich-119	227	1	a	a	DET
biomedich-119	227	2	brief	brief	ADJ
biomedich-119	227	3	history	history	NOUN
biomedich-119	227	4	of	of	ADP
biomedich-119	227	5	gene	gene	NOUN
biomedich-119	227	6	therapy	therapy	NOUN
biomedich-119	227	7	.	.	PUNCT
biomedich-119	228	1	nature	nature	NOUN
biomedich-119	228	2	genetics	genetic	NOUN
biomedich-119	228	3	,	,	PUNCT
biomedich-119	228	4	2(2	2(2	NUM
biomedich-119	228	5	)	)	PUNCT
biomedich-119	228	6	,	,	PUNCT
biomedich-119	228	7	pp.93	pp.93	NOUN
biomedich-119	228	8	-	-	PUNCT
biomedich-119	228	9	98	98	NUM
biomedich-119	228	10	.	.	PUNCT
biomedich-119	229	1	froud	froud	PROPN
biomedich-119	229	2	,	,	PUNCT
biomedich-119	229	3	t.	t.	PROPN
biomedich-119	229	4	,	,	PUNCT
biomedich-119	229	5	ricordi	ricordi	PROPN
biomedich-119	229	6	,	,	PUNCT
biomedich-119	229	7	c.	c.	PROPN
biomedich-119	229	8	,	,	PUNCT
biomedich-119	229	9	baidal	baidal	NOUN
biomedich-119	229	10	,	,	PUNCT
biomedich-119	229	11	d.a	d.a	PROPN
biomedich-119	229	12	.	.	PROPN
biomedich-119	229	13	,	,	PUNCT
biomedich-119	229	14	hafiz	hafiz	PROPN
biomedich-119	229	15	,	,	PUNCT
biomedich-119	229	16	m.m	m.m	PROPN
biomedich-119	229	17	.	.	PROPN
biomedich-119	229	18	,	,	PUNCT
biomedich-119	229	19	ponte	ponte	PROPN
biomedich-119	229	20	,	,	PUNCT
biomedich-119	229	21	g.	g.	NOUN
biomedich-119	229	22	,	,	PUNCT
biomedich-119	229	23	cure	cure	NOUN
biomedich-119	229	24	,	,	PUNCT
biomedich-119	229	25	p.	p.	NOUN
biomedich-119	229	26	,	,	PUNCT
biomedich-119	229	27	pileggi	pileggi	NOUN
biomedich-119	229	28	,	,	PUNCT
biomedich-119	229	29	a.	a.	NOUN
biomedich-119	229	30	,	,	PUNCT
biomedich-119	229	31	poggioli	poggioli	PROPN
biomedich-119	229	32	,	,	PUNCT
biomedich-119	229	33	r.	r.	PROPN
biomedich-119	229	34	,	,	PUNCT
biomedich-119	229	35	ichii	ichii	PROPN
biomedich-119	229	36	,	,	PUNCT
biomedich-119	229	37	h.	h.	PROPN
biomedich-119	229	38	,	,	PUNCT
biomedich-119	229	39	khan	khan	PROPN
biomedich-119	229	40	,	,	PUNCT
biomedich-119	229	41	a.	a.	PROPN
biomedich-119	229	42	and	and	CCONJ
biomedich-119	229	43	ferreira	ferreira	PROPN
biomedich-119	229	44	,	,	PUNCT
biomedich-119	229	45	j.v	j.v	PROPN
biomedich-119	229	46	.	.	PROPN
biomedich-119	229	47	,	,	PUNCT
biomedich-119	229	48	2005	2005	NUM
biomedich-119	229	49	.	.	PUNCT
biomedich-119	230	1	islet	islet	NOUN
biomedich-119	230	2	transplantation	transplantation	NOUN
biomedich-119	230	3	in	in	ADP
biomedich-119	230	4	type	type	NOUN
biomedich-119	230	5	1	1	NUM
biomedich-119	230	6	diabetes	diabetes	NOUN
biomedich-119	230	7	mellitus	mellitus	NOUN
biomedich-119	230	8	using	use	VERB
biomedich-119	230	9	cultured	cultured	ADJ
biomedich-119	230	10	islets	islet	NOUN
biomedich-119	230	11	and	and	CCONJ
biomedich-119	230	12	steroid‐free	steroid‐free	NOUN
biomedich-119	230	13	immunosuppression	immunosuppression	NOUN
biomedich-119	230	14	:	:	PUNCT
biomedich-119	230	15	miami	miami	PROPN
biomedich-119	230	16	experience	experience	NOUN
biomedich-119	230	17	.	.	PUNCT
biomedich-119	231	1	american	american	ADJ
biomedich-119	231	2	journal	journal	PROPN
biomedich-119	231	3	of	of	ADP
biomedich-119	231	4	transplantation	transplantation	NOUN
biomedich-119	231	5	,	,	PUNCT
biomedich-119	231	6	5(8	5(8	NUM
biomedich-119	231	7	)	)	PUNCT
biomedich-119	231	8	,	,	PUNCT
biomedich-119	231	9	pp.2037	pp.2037	PROPN
biomedich-119	231	10	-	-	PUNCT
biomedich-119	231	11	2046	2046	NUM
biomedich-119	231	12	.	.	PUNCT
biomedich-119	232	1	fujikawa	fujikawa	PROPN
biomedich-119	232	2	,	,	PUNCT
biomedich-119	232	3	t.	t.	PROPN
biomedich-119	232	4	,	,	PUNCT
biomedich-119	232	5	chuang	chuang	PROPN
biomedich-119	232	6	,	,	PUNCT
biomedich-119	232	7	j.c	j.c	PROPN
biomedich-119	232	8	.	.	PROPN
biomedich-119	232	9	,	,	PUNCT
biomedich-119	232	10	sakata	sakata	PROPN
biomedich-119	232	11	,	,	PUNCT
biomedich-119	232	12	i.	i.	PROPN
biomedich-119	232	13	,	,	PUNCT
biomedich-119	232	14	ramadori	ramadori	X
biomedich-119	232	15	,	,	PUNCT
biomedich-119	232	16	g.	g.	PROPN
biomedich-119	232	17	and	and	CCONJ
biomedich-119	232	18	coppari	coppari	PROPN
biomedich-119	232	19	,	,	PUNCT
biomedich-119	232	20	r.	r.	PROPN
biomedich-119	232	21	,	,	PUNCT
biomedich-119	232	22	2010	2010	NUM
biomedich-119	232	23	.	.	PUNCT
biomedich-119	233	1	leptin	leptin	NOUN
biomedich-119	233	2	therapy	therapy	NOUN
biomedich-119	233	3	improves	improve	VERB
biomedich-119	233	4	insulin	insulin	NOUN
biomedich-119	233	5	-	-	PUNCT
biomedich-119	233	6	deficient	deficient	ADJ
biomedich-119	233	7	type	type	NOUN
biomedich-119	233	8	1	1	NUM
biomedich-119	233	9	diabetes	diabetes	NOUN
biomedich-119	233	10	by	by	ADP
biomedich-119	233	11	cns	cns	NOUN
biomedich-119	233	12	-	-	PUNCT
biomedich-119	233	13	dependent	dependent	ADJ
biomedich-119	233	14	mechanisms	mechanism	NOUN
biomedich-119	233	15	in	in	ADP
biomedich-119	233	16	mice	mouse	NOUN
biomedich-119	233	17	.	.	PUNCT
biomedich-119	234	1	proceedings	proceeding	NOUN
biomedich-119	234	2	of	of	ADP
biomedich-119	234	3	the	the	DET
biomedich-119	234	4	national	national	PROPN
biomedich-119	234	5	academy	academy	PROPN
biomedich-119	234	6	of	of	ADP
biomedich-119	234	7	sciences	sciences	PROPN
biomedich-119	234	8	,	,	PUNCT
biomedich-119	234	9	107(40	107(40	NUM
biomedich-119	234	10	)	)	PUNCT
biomedich-119	234	11	,	,	PUNCT
biomedich-119	234	12	pp.17391	pp.17391	PROPN
biomedich-119	234	13	-	-	PROPN
biomedich-119	234	14	17396	17396	NUM
biomedich-119	234	15	.	.	PUNCT
biomedich-119	235	1	ginn	ginn	PROPN
biomedich-119	235	2	,	,	PUNCT
biomedich-119	235	3	s.l	s.l	PROPN
biomedich-119	235	4	.	.	PROPN
biomedich-119	235	5	,	,	PUNCT
biomedich-119	235	6	amaya	amaya	PROPN
biomedich-119	235	7	,	,	PUNCT
biomedich-119	235	8	a.k	a.k	PROPN
biomedich-119	235	9	.	.	PROPN
biomedich-119	235	10	,	,	PUNCT
biomedich-119	235	11	alexander	alexander	PROPN
biomedich-119	235	12	,	,	PUNCT
biomedich-119	235	13	i.e.	i.e.	X
biomedich-119	235	14	,	,	PUNCT
biomedich-119	235	15	edelstein	edelstein	PROPN
biomedich-119	235	16	,	,	PUNCT
biomedich-119	235	17	m.	m.	NOUN
biomedich-119	235	18	and	and	CCONJ
biomedich-119	235	19	abedi	abedi	PROPN
biomedich-119	235	20	,	,	PUNCT
biomedich-119	235	21	m.r	m.r	PROPN
biomedich-119	235	22	.	.	PROPN
biomedich-119	235	23	,	,	PUNCT
biomedich-119	235	24	2018	2018	NUM
biomedich-119	235	25	.	.	PUNCT
biomedich-119	236	1	gene	gene	NOUN
biomedich-119	236	2	therapy	therapy	NOUN
biomedich-119	236	3	clinical	clinical	ADJ
biomedich-119	236	4	trials	trial	NOUN
biomedich-119	236	5	worldwide	worldwide	ADV
biomedich-119	236	6	to	to	ADP
biomedich-119	236	7	2017	2017	NUM
biomedich-119	236	8	:	:	PUNCT
biomedich-119	236	9	an	an	DET
biomedich-119	236	10	update	update	NOUN
biomedich-119	236	11	.	.	PUNCT
biomedich-119	237	1	the	the	DET
biomedich-119	237	2	journal	journal	NOUN
biomedich-119	237	3	of	of	ADP
biomedich-119	237	4	gene	gene	NOUN
biomedich-119	237	5	medicine	medicine	NOUN
biomedich-119	237	6	,	,	PUNCT
biomedich-119	237	7	20(5	20(5	NOUN
biomedich-119	237	8	)	)	PUNCT
biomedich-119	237	9	,	,	PUNCT
biomedich-119	237	10	p.e3015	p.e3015	PROPN
biomedich-119	237	11	.	.	PUNCT
biomedich-119	238	1	goins	goins	PROPN
biomedich-119	238	2	,	,	PUNCT
biomedich-119	238	3	w.f	w.f	PROPN
biomedich-119	238	4	.	.	PROPN
biomedich-119	238	5	,	,	PUNCT
biomedich-119	238	6	huang	huang	PROPN
biomedich-119	238	7	,	,	PUNCT
biomedich-119	238	8	s.	s.	PROPN
biomedich-119	238	9	,	,	PUNCT
biomedich-119	238	10	hall	hall	PROPN
biomedich-119	238	11	,	,	PUNCT
biomedich-119	238	12	b.	b.	PROPN
biomedich-119	238	13	,	,	PUNCT
biomedich-119	238	14	marzulli	marzulli	PROPN
biomedich-119	238	15	,	,	PUNCT
biomedich-119	238	16	m.	m.	NOUN
biomedich-119	238	17	,	,	PUNCT
biomedich-119	238	18	cohen	cohen	PROPN
biomedich-119	238	19	,	,	PUNCT
biomedich-119	238	20	j.b	j.b	PROPN
biomedich-119	238	21	.	.	PROPN
biomedich-119	238	22	and	and	CCONJ
biomedich-119	238	23	glorioso	glorioso	PROPN
biomedich-119	238	24	,	,	PUNCT
biomedich-119	238	25	j.c	j.c	PROPN
biomedich-119	238	26	.	.	PROPN
biomedich-119	238	27	,	,	PUNCT
biomedich-119	238	28	2020	2020	NUM
biomedich-119	238	29	.	.	PUNCT
biomedich-119	239	1	engineering	engineer	VERB
biomedich-119	239	2	hsv-1	hsv-1	NOUN
biomedich-119	239	3	vectors	vector	NOUN
biomedich-119	239	4	for	for	ADP
biomedich-119	239	5	gene	gene	NOUN
biomedich-119	239	6	therapy	therapy	NOUN
biomedich-119	239	7	.	.	PUNCT
biomedich-119	240	1	in	in	ADP
biomedich-119	240	2	herpes	herpe	NOUN
biomedich-119	240	3	simplex	simplex	NOUN
biomedich-119	240	4	virus	virus	NOUN
biomedich-119	240	5	(	(	PUNCT
biomedich-119	240	6	pp	pp	ADJ
biomedich-119	240	7	.	.	PUNCT
biomedich-119	241	1	73	73	NUM
biomedich-119	241	2	-	-	SYM
biomedich-119	241	3	90	90	NUM
biomedich-119	241	4	)	)	PUNCT
biomedich-119	241	5	.	.	PUNCT
biomedich-119	242	1	humana	humana	PROPN
biomedich-119	242	2	,	,	PUNCT
biomedich-119	242	3	new	new	PROPN
biomedich-119	242	4	york	york	PROPN
biomedich-119	242	5	,	,	PUNCT
biomedich-119	242	6	ny	ny	PROPN
biomedich-119	242	7	.	.	PROPN
biomedich-119	242	8	guney	guney	PROPN
biomedich-119	242	9	,	,	PUNCT
biomedich-119	242	10	m.a	m.a	PROPN
biomedich-119	242	11	.	.	PROPN
biomedich-119	242	12	,	,	PUNCT
biomedich-119	242	13	lorberbaum	lorberbaum	PROPN
biomedich-119	242	14	,	,	PUNCT
biomedich-119	242	15	d.s	d.s	PROPN
biomedich-119	242	16	.	.	PROPN
biomedich-119	242	17	and	and	CCONJ
biomedich-119	242	18	sussel	sussel	PROPN
biomedich-119	242	19	,	,	PUNCT
biomedich-119	242	20	l.	l.	PROPN
biomedich-119	242	21	,	,	PUNCT
biomedich-119	242	22	2020	2020	NUM
biomedich-119	242	23	.	.	PUNCT
biomedich-119	243	1	pancreatic	pancreatic	ADJ
biomedich-119	243	2	β	β	PROPN
biomedich-119	243	3	cell	cell	NOUN
biomedich-119	243	4	regeneration	regeneration	NOUN
biomedich-119	243	5	:	:	PUNCT
biomedich-119	243	6	to	to	ADP
biomedich-119	243	7	β	β	NOUN
biomedich-119	243	8	or	or	CCONJ
biomedich-119	243	9	not	not	PART
biomedich-119	243	10	to	to	PART
biomedich-119	243	11	β	β	X
biomedich-119	243	12	.	.	PUNCT
biomedich-119	244	1	current	current	ADJ
biomedich-119	244	2	opinion	opinion	NOUN
biomedich-119	244	3	in	in	ADP
biomedich-119	244	4	physiology	physiology	NOUN
biomedich-119	244	5	,	,	PUNCT
biomedich-119	244	6	14	14	NUM
biomedich-119	244	7	,	,	PUNCT
biomedich-119	244	8	pp.13	pp.13	NOUN
biomedich-119	244	9	-	-	NOUN
biomedich-119	244	10	20	20	NUM
biomedich-119	244	11	.	.	PUNCT
biomedich-119	245	1	handorf	handorf	PROPN
biomedich-119	245	2	,	,	PUNCT
biomedich-119	245	3	a.m.	a.m.	ADV
biomedich-119	245	4	,	,	PUNCT
biomedich-119	245	5	sollinger	sollinger	AUX
biomedich-119	245	6	,	,	PUNCT
biomedich-119	245	7	h.w	h.w	PROPN
biomedich-119	245	8	.	.	PROPN
biomedich-119	245	9	and	and	CCONJ
biomedich-119	245	10	alam	alam	PROPN
biomedich-119	245	11	,	,	PUNCT
biomedich-119	245	12	t.	t.	PROPN
biomedich-119	245	13	,	,	PUNCT
biomedich-119	245	14	2015	2015	NUM
biomedich-119	245	15	.	.	PUNCT
biomedich-119	246	1	insulin	insulin	NOUN
biomedich-119	246	2	gene	gene	NOUN
biomedich-119	246	3	therapy	therapy	NOUN
biomedich-119	246	4	for	for	ADP
biomedich-119	246	5	type	type	NOUN
biomedich-119	246	6	1	1	NUM
biomedich-119	246	7	diabetes	diabetes	NOUN
biomedich-119	246	8	mellitus	mellitus	NOUN
biomedich-119	246	9	.	.	PUNCT
biomedich-119	247	1	exp	exp	NOUN
biomedich-119	247	2	clin	clin	PROPN
biomedich-119	247	3	transplant	transplant	NOUN
biomedich-119	247	4	,	,	PUNCT
biomedich-119	247	5	13(suppl	13(suppl	NUM
biomedich-119	247	6	1	1	NUM
biomedich-119	247	7	)	)	PUNCT
biomedich-119	247	8	,	,	PUNCT
biomedich-119	247	9	pp.37	pp.37	PROPN
biomedich-119	247	10	-	-	SYM
biomedich-119	247	11	45	45	NUM
biomedich-119	247	12	.	.	PUNCT
biomedich-119	248	1	jeong	jeong	PROPN
biomedich-119	248	2	,	,	PUNCT
biomedich-119	248	3	y.	y.	PROPN
biomedich-119	248	4	,	,	PUNCT
biomedich-119	248	5	park	park	NOUN
biomedich-119	248	6	,	,	PUNCT
biomedich-119	248	7	j.k.h	j.k.h	NOUN
biomedich-119	248	8	.	.	PROPN
biomedich-119	248	9	and	and	CCONJ
biomedich-119	248	10	eun	eun	PROPN
biomedich-119	248	11	,	,	PUNCT
biomedich-119	248	12	s.	s.	PROPN
biomedich-119	248	13	,	,	PUNCT
biomedich-119	248	14	2020	2020	NUM
biomedich-119	248	15	,	,	PUNCT
biomedich-119	248	16	may	may	AUX
biomedich-119	248	17	.	.	PUNCT
biomedich-119	249	1	viral	viral	ADJ
biomedich-119	249	2	vector	vector	NOUN
biomedich-119	249	3	mediated	mediate	VERB
biomedich-119	250	1	interleukin-10	interleukin-10	CCONJ
biomedich-119	250	2	gene	gene	NOUN
biomedich-119	250	3	transfer	transfer	NOUN
biomedich-119	250	4	in	in	ADP
biomedich-119	250	5	skin	skin	NOUN
biomedich-119	250	6	allograft	allograft	NOUN
biomedich-119	250	7	.	.	PUNCT
biomedich-119	251	1	in	in	ADP
biomedich-119	251	2	transplantation	transplantation	NOUN
biomedich-119	251	3	proceedings	proceeding	NOUN
biomedich-119	251	4	.	.	PUNCT
biomedich-119	252	1	elsevier	elsevier	NOUN
biomedich-119	252	2	.	.	PUNCT
biomedich-119	253	1	kanao	kanao	PROPN
biomedich-119	253	2	-	-	PUNCT
biomedich-119	253	3	kanda	kanda	PROPN
biomedich-119	253	4	,	,	PUNCT
biomedich-119	253	5	m.	m.	NOUN
biomedich-119	253	6	,	,	PUNCT
biomedich-119	253	7	kanda	kanda	PROPN
biomedich-119	253	8	,	,	PUNCT
biomedich-119	253	9	h.	h.	PROPN
biomedich-119	253	10	,	,	PUNCT
biomedich-119	253	11	liu	liu	PROPN
biomedich-119	253	12	,	,	PUNCT
biomedich-119	253	13	s.	s.	PROPN
biomedich-119	253	14	,	,	PUNCT
biomedich-119	253	15	roy	roy	PROPN
biomedich-119	253	16	,	,	PUNCT
biomedich-119	253	17	s.	s.	PROPN
biomedich-119	253	18	,	,	PUNCT
biomedich-119	253	19	toborek	toborek	NOUN
biomedich-119	253	20	,	,	PUNCT
biomedich-119	253	21	m.	m.	NOUN
biomedich-119	253	22	and	and	CCONJ
biomedich-119	253	23	hao	hao	PROPN
biomedich-119	253	24	,	,	PUNCT
biomedich-119	253	25	s.	s.	PROPN
biomedich-119	253	26	,	,	PUNCT
biomedich-119	253	27	2020	2020	NUM
biomedich-119	253	28	.	.	PUNCT
biomedich-119	254	1	viral	viral	ADJ
biomedich-119	254	2	vector	vector	NOUN
biomedich-119	254	3	–	–	PUNCT
biomedich-119	254	4	mediated	mediate	VERB
biomedich-119	254	5	gene	gene	NOUN
biomedich-119	254	6	transfer	transfer	NOUN
biomedich-119	254	7	of	of	ADP
biomedich-119	254	8	glutamic	glutamic	ADJ
biomedich-119	254	9	acid	acid	NOUN
biomedich-119	254	10	decarboxylase	decarboxylase	NOUN
biomedich-119	254	11	for	for	ADP
biomedich-119	254	12	chronic	chronic	ADJ
biomedich-119	254	13	pain	pain	NOUN
biomedich-119	254	14	treatment	treatment	NOUN
biomedich-119	254	15	:	:	PUNCT
biomedich-119	254	16	a	a	DET
biomedich-119	254	17	literature	literature	NOUN
biomedich-119	254	18	review	review	NOUN
biomedich-119	254	19	.	.	PUNCT
biomedich-119	255	1	human	human	ADJ
biomedich-119	255	2	gene	gene	NOUN
biomedich-119	255	3	therapy	therapy	NOUN
biomedich-119	255	4	,	,	PUNCT
biomedich-119	255	5	31(7	31(7	PROPN
biomedich-119	255	6	-	-	SYM
biomedich-119	255	7	8)	8)	NUM
biomedich-119	255	8	,	,	PUNCT
biomedich-119	255	9	pp.405	pp.405	PROPN
biomedich-119	255	10	-	-	PUNCT
biomedich-119	255	11	414	414	NUM
biomedich-119	255	12	.	.	PUNCT
biomedich-119	256	1	kato	kato	PROPN
biomedich-119	256	2	,	,	PUNCT
biomedich-119	256	3	n.	n.	PROPN
biomedich-119	256	4	,	,	PUNCT
biomedich-119	256	5	nemoto	nemoto	NOUN
biomedich-119	256	6	,	,	PUNCT
biomedich-119	256	7	k.	k.	PROPN
biomedich-119	256	8	,	,	PUNCT
biomedich-119	256	9	nakanishi	nakanishi	PROPN
biomedich-119	256	10	,	,	PUNCT
biomedich-119	256	11	k.	k.	PROPN
biomedich-119	256	12	,	,	PUNCT
biomedich-119	256	13	morishita	morishita	PROPN
biomedich-119	256	14	,	,	PUNCT
biomedich-119	256	15	r.	r.	PROPN
biomedich-119	256	16	,	,	PUNCT
biomedich-119	256	17	kaneda	kaneda	PROPN
biomedich-119	256	18	,	,	PUNCT
biomedich-119	256	19	y.	y.	PROPN
biomedich-119	256	20	,	,	PUNCT
biomedich-119	256	21	uenoyama	uenoyama	PROPN
biomedich-119	256	22	,	,	PUNCT
biomedich-119	256	23	m.	m.	NOUN
biomedich-119	256	24	,	,	PUNCT
biomedich-119	256	25	ikeda	ikeda	PROPN
biomedich-119	256	26	,	,	PUNCT
biomedich-119	256	27	t.	t.	PROPN
biomedich-119	256	28	and	and	CCONJ
biomedich-119	256	29	fujikawa	fujikawa	PROPN
biomedich-119	256	30	,	,	PUNCT
biomedich-119	256	31	k.	k.	PROPN
biomedich-119	256	32	,	,	PUNCT
biomedich-119	256	33	2005	2005	NUM
biomedich-119	256	34	.	.	PUNCT
biomedich-119	257	1	nonviral	nonviral	ADJ
biomedich-119	257	2	gene	gene	NOUN
biomedich-119	257	3	transfer	transfer	NOUN
biomedich-119	257	4	of	of	ADP
biomedich-119	257	5	human	human	ADJ
biomedich-119	257	6	hepatocyte	hepatocyte	NOUN
biomedich-119	257	7	growth	growth	NOUN
biomedich-119	257	8	factor	factor	NOUN
biomedich-119	257	9	improves	improve	VERB
biomedich-119	257	10	streptozotocin	streptozotocin	NOUN
biomedich-119	257	11	-	-	PUNCT
biomedich-119	257	12	induced	induce	VERB
biomedich-119	257	13	diabetic	diabetic	NOUN
biomedich-119	257	14	neuropathy	neuropathy	ADJ
biomedich-119	257	15	in	in	ADP
biomedich-119	257	16	rats	rat	NOUN
biomedich-119	257	17	.	.	PUNCT
biomedich-119	258	1	diabetes	diabetes	NOUN
biomedich-119	258	2	,	,	PUNCT
biomedich-119	258	3	54(3	54(3	NUM
biomedich-119	258	4	)	)	PUNCT
biomedich-119	258	5	,	,	PUNCT
biomedich-119	258	6	pp.846	pp.846	NOUN
biomedich-119	258	7	-	-	SYM
biomedich-119	258	8	854	854	NUM
biomedich-119	258	9	.	.	PUNCT
biomedich-119	259	1	kaur	kaur	PROPN
biomedich-119	259	2	,	,	PUNCT
biomedich-119	259	3	k.k	k.k	PROPN
biomedich-119	259	4	.	.	PROPN
biomedich-119	259	5	,	,	PUNCT
biomedich-119	259	6	2020	2020	NUM
biomedich-119	259	7	.	.	PUNCT
biomedich-119	260	1	attempting	attempt	VERB
biomedich-119	260	2	getting	get	VERB
biomedich-119	260	3	insulin	insulin	NOUN
biomedich-119	260	4	independent	independent	ADJ
biomedich-119	260	5	immunotherapies	immunotherapy	NOUN
biomedich-119	260	6	in	in	ADP
biomedich-119	260	7	type	type	NOUN
biomedich-119	260	8	1	1	NUM
biomedich-119	260	9	diabetes	diabetes	NOUN
biomedich-119	260	10	mellitus	mellitus	NOUN
biomedich-119	260	11	(	(	PUNCT
biomedich-119	260	12	t1d	t1d	PROPN
biomedich-119	260	13	)	)	PUNCT
biomedich-119	260	14	in	in	ADP
biomedich-119	260	15	the	the	DET
biomedich-119	260	16	pre	pre	ADJ
biomedich-119	260	17	stage	stage	NOUN
biomedich-119	260	18	1	1	NUM
biomedich-119	260	19	(	(	PUNCT
biomedich-119	260	20	before	before	ADP
biomedich-119	260	21	islet	islet	NOUN
biomedich-119	260	22	autoantibodies	autoantibody	NOUN
biomedich-119	260	23	)	)	PUNCT
biomedich-119	260	24	.	.	PUNCT
biomedich-119	261	1	acta	acta	PROPN
biomedich-119	261	2	scientific	scientific	ADJ
biomedich-119	261	3	paediatrics	paediatric	NOUN
biomedich-119	261	4	,	,	PUNCT
biomedich-119	261	5	3	3	NUM
biomedich-119	261	6	,	,	PUNCT
biomedich-119	261	7	pp.01	pp.01	NOUN
biomedich-119	261	8	-	-	PUNCT
biomedich-119	261	9	04	04	NUM
biomedich-119	261	10	.	.	PUNCT
biomedich-119	262	1	kharroubi	kharroubi	PROPN
biomedich-119	262	2	,	,	PUNCT
biomedich-119	262	3	a.t	a.t	PROPN
biomedich-119	262	4	.	.	PROPN
biomedich-119	262	5	and	and	CCONJ
biomedich-119	262	6	darwish	darwish	PROPN
biomedich-119	262	7	,	,	PUNCT
biomedich-119	262	8	h.m	h.m	PROPN
biomedich-119	262	9	.	.	PROPN
biomedich-119	262	10	,	,	PUNCT
biomedich-119	262	11	2015	2015	NUM
biomedich-119	262	12	.	.	PUNCT
biomedich-119	263	1	diabetes	diabetes	NOUN
biomedich-119	263	2	mellitus	mellitus	NOUN
biomedich-119	263	3	:	:	PUNCT
biomedich-119	263	4	the	the	DET
biomedich-119	263	5	epidemic	epidemic	NOUN
biomedich-119	263	6	of	of	ADP
biomedich-119	263	7	the	the	DET
biomedich-119	263	8	century	century	NOUN
biomedich-119	263	9	.	.	PUNCT
biomedich-119	264	1	world	world	PROPN
biomedich-119	264	2	journal	journal	PROPN
biomedich-119	264	3	of	of	ADP
biomedich-119	264	4	diabetes	diabetes	NOUN
biomedich-119	264	5	,	,	PUNCT
biomedich-119	264	6	6(6	6(6	NUM
biomedich-119	264	7	)	)	PUNCT
biomedich-119	264	8	,	,	PUNCT
biomedich-119	264	9	p.850	p.850	NOUN
biomedich-119	264	10	.	.	PUNCT
biomedich-119	265	1	kolodka	kolodka	PROPN
biomedich-119	265	2	,	,	PUNCT
biomedich-119	265	3	t.m	t.m	PROPN
biomedich-119	265	4	.	.	PROPN
biomedich-119	265	5	,	,	PUNCT
biomedich-119	265	6	finegold	finegold	VERB
biomedich-119	265	7	,	,	PUNCT
biomedich-119	265	8	m.	m.	NOUN
biomedich-119	265	9	,	,	PUNCT
biomedich-119	265	10	moss	moss	NOUN
biomedich-119	265	11	,	,	PUNCT
biomedich-119	265	12	l.	l.	PROPN
biomedich-119	265	13	and	and	CCONJ
biomedich-119	265	14	woo	woo	PROPN
biomedich-119	265	15	,	,	PUNCT
biomedich-119	265	16	s.l	s.l	PROPN
biomedich-119	265	17	.	.	PROPN
biomedich-119	265	18	,	,	PUNCT
biomedich-119	265	19	1995	1995	NUM
biomedich-119	265	20	.	.	PUNCT
biomedich-119	266	1	gene	gene	NOUN
biomedich-119	266	2	therapy	therapy	NOUN
biomedich-119	266	3	for	for	ADP
biomedich-119	266	4	diabetes	diabetes	NOUN
biomedich-119	266	5	mellitus	mellitus	NOUN
biomedich-119	266	6	in	in	ADP
biomedich-119	266	7	rats	rat	NOUN
biomedich-119	266	8	by	by	ADP
biomedich-119	266	9	hepatic	hepatic	ADJ
biomedich-119	266	10	expression	expression	NOUN
biomedich-119	266	11	of	of	ADP
biomedich-119	266	12	insulin	insulin	NOUN
biomedich-119	266	13	.	.	PUNCT
biomedich-119	267	1	proceedings	proceeding	NOUN
biomedich-119	267	2	of	of	ADP
biomedich-119	267	3	the	the	DET
biomedich-119	267	4	national	national	PROPN
biomedich-119	267	5	academy	academy	PROPN
biomedich-119	267	6	of	of	ADP
biomedich-119	267	7	sciences	sciences	PROPN
biomedich-119	267	8	,	,	PUNCT
biomedich-119	267	9	92(8	92(8	NUM
biomedich-119	267	10	)	)	PUNCT
biomedich-119	267	11	,	,	PUNCT
biomedich-119	267	12	pp.3293	pp.3293	NOUN
biomedich-119	267	13	-	-	PUNCT
biomedich-119	267	14	3297	3297	NUM
biomedich-119	267	15	.	.	PUNCT
biomedich-119	268	1	lakhtakia	lakhtakia	PROPN
biomedich-119	268	2	,	,	PUNCT
biomedich-119	268	3	r.	r.	PROPN
biomedich-119	268	4	,	,	PUNCT
biomedich-119	268	5	2013	2013	NUM
biomedich-119	268	6	.	.	PUNCT
biomedich-119	269	1	the	the	DET
biomedich-119	269	2	history	history	NOUN
biomedich-119	269	3	of	of	ADP
biomedich-119	269	4	diabetes	diabetes	NOUN
biomedich-119	269	5	mellitus	mellitus	NOUN
biomedich-119	269	6	.	.	PUNCT
biomedich-119	270	1	sultan	sultan	PROPN
biomedich-119	270	2	qaboos	qaboos	PROPN
biomedich-119	270	3	university	university	PROPN
biomedich-119	270	4	medical	medical	ADJ
biomedich-119	270	5	journal	journal	NOUN
biomedich-119	270	6	,	,	PUNCT
biomedich-119	270	7	13(3	13(3	NUM
biomedich-119	270	8	)	)	PUNCT
biomedich-119	270	9	,	,	PUNCT
biomedich-119	270	10	p.368	p.368	PROPN
biomedich-119	270	11	.	.	PUNCT
biomedich-119	270	12	latres	latres	PROPN
biomedich-119	270	13	,	,	PUNCT
biomedich-119	270	14	e.	e.	PROPN
biomedich-119	270	15	,	,	PUNCT
biomedich-119	270	16	finan	finan	PROPN
biomedich-119	270	17	,	,	PUNCT
biomedich-119	270	18	d.a	d.a	PROPN
biomedich-119	270	19	.	.	PROPN
biomedich-119	270	20	,	,	PUNCT
biomedich-119	270	21	greenstein	greenstein	PROPN
biomedich-119	270	22	,	,	PUNCT
biomedich-119	270	23	j.l	j.l	PROPN
biomedich-119	270	24	.	.	PROPN
biomedich-119	270	25	,	,	PUNCT
biomedich-119	270	26	kowalski	kowalski	PROPN
biomedich-119	270	27	,	,	PUNCT
biomedich-119	270	28	a.	a.	NOUN
biomedich-119	270	29	and	and	CCONJ
biomedich-119	270	30	kieffer	kieffer	PROPN
biomedich-119	270	31	,	,	PUNCT
biomedich-119	270	32	t.j	t.j	PROPN
biomedich-119	270	33	.	.	PROPN
biomedich-119	270	34	,	,	PUNCT
biomedich-119	270	35	2019	2019	NUM
biomedich-119	270	36	.	.	PUNCT
biomedich-119	271	1	navigating	navigate	VERB
biomedich-119	271	2	two	two	NUM
biomedich-119	271	3	roads	road	NOUN
biomedich-119	271	4	to	to	ADP
biomedich-119	271	5	glucose	glucose	VERB
biomedich-119	271	6	normalization	normalization	NOUN
biomedich-119	271	7	in	in	ADP
biomedich-119	271	8	diabetes	diabetes	NOUN
biomedich-119	271	9	:	:	PUNCT
biomedich-119	271	10	automated	automate	VERB
biomedich-119	271	11	insulin	insulin	NOUN
biomedich-119	271	12	delivery	delivery	NOUN
biomedich-119	271	13	devices	device	NOUN
biomedich-119	271	14	and	and	CCONJ
biomedich-119	271	15	cell	cell	NOUN
biomedich-119	271	16	therapy	therapy	NOUN
biomedich-119	271	17	.	.	PUNCT
biomedich-119	272	1	cell	cell	NOUN
biomedich-119	272	2	metabolism	metabolism	NOUN
biomedich-119	272	3	,	,	PUNCT
biomedich-119	272	4	29(3	29(3	NUM
biomedich-119	272	5	)	)	PUNCT
biomedich-119	272	6	,	,	PUNCT
biomedich-119	272	7	pp.545	pp.545	PROPN
biomedich-119	272	8	-	-	PROPN
biomedich-119	272	9	563	563	NUM
biomedich-119	272	10	.	.	PUNCT
biomedich-119	273	1	le	le	PROPN
biomedich-119	273	2	bagge	bagge	PROPN
biomedich-119	273	3	,	,	PUNCT
biomedich-119	273	4	s.	s.	PROPN
biomedich-119	273	5	,	,	PUNCT
biomedich-119	273	6	fotheringham	fotheringham	PROPN
biomedich-119	273	7	,	,	PUNCT
biomedich-119	273	8	a.k	a.k	PROPN
biomedich-119	273	9	.	.	PROPN
biomedich-119	273	10	,	,	PUNCT
biomedich-119	273	11	leung	leung	PROPN
biomedich-119	273	12	,	,	PUNCT
biomedich-119	273	13	s.s	s.s	PROPN
biomedich-119	273	14	.	.	PROPN
biomedich-119	273	15	and	and	CCONJ
biomedich-119	273	16	forbes	forbes	PROPN
biomedich-119	273	17	,	,	PUNCT
biomedich-119	273	18	j.m	j.m	PROPN
biomedich-119	273	19	.	.	PROPN
biomedich-119	273	20	,	,	PUNCT
biomedich-119	273	21	2020	2020	NUM
biomedich-119	273	22	.	.	PUNCT
biomedich-119	274	1	targeting	target	VERB
biomedich-119	274	2	the	the	DET
biomedich-119	274	3	receptor	receptor	NOUN
biomedich-119	274	4	for	for	ADP
biomedich-119	274	5	advanced	advanced	ADJ
biomedich-119	274	6	glycation	glycation	NOUN
biomedich-119	274	7	end	end	NOUN
biomedich-119	274	8	products	product	NOUN
biomedich-119	274	9	(	(	PUNCT
biomedich-119	274	10	rage	rage	NOUN
biomedich-119	274	11	)	)	PUNCT
biomedich-119	274	12	in	in	ADP
biomedich-119	274	13	type	type	NOUN
biomedich-119	274	14	1	1	NUM
biomedich-119	274	15	diabetes	diabetes	NOUN
biomedich-119	274	16	.	.	PUNCT
biomedich-119	275	1	medicinal	medicinal	ADJ
biomedich-119	275	2	research	research	NOUN
biomedich-119	275	3	reviews	review	NOUN
biomedich-119	275	4	.	.	PUNCT
biomedich-119	276	1	lee	lee	PROPN
biomedich-119	276	2	,	,	PUNCT
biomedich-119	276	3	h.c	h.c	PROPN
biomedich-119	276	4	.	.	PROPN
biomedich-119	276	5	,	,	PUNCT
biomedich-119	276	6	kim	kim	PROPN
biomedich-119	276	7	,	,	PUNCT
biomedich-119	276	8	s.j	s.j	PROPN
biomedich-119	276	9	.	.	PROPN
biomedich-119	276	10	,	,	PUNCT
biomedich-119	276	11	kim	kim	PROPN
biomedich-119	276	12	,	,	PUNCT
biomedich-119	276	13	k.s	k.s	PROPN
biomedich-119	276	14	.	.	PROPN
biomedich-119	276	15	,	,	PUNCT
biomedich-119	276	16	shin	shin	PROPN
biomedich-119	276	17	,	,	PUNCT
biomedich-119	276	18	h.c	h.c	PROPN
biomedich-119	276	19	.	.	PROPN
biomedich-119	276	20	and	and	CCONJ
biomedich-119	276	21	yoon	yoon	PROPN
biomedich-119	276	22	,	,	PUNCT
biomedich-119	276	23	j.w	j.w	PROPN
biomedich-119	276	24	.	.	PROPN
biomedich-119	276	25	,	,	PUNCT
biomedich-119	276	26	2000	2000	NUM
biomedich-119	276	27	.	.	PUNCT
biomedich-119	277	1	remission	remission	NOUN
biomedich-119	277	2	in	in	ADP
biomedich-119	277	3	models	model	NOUN
biomedich-119	277	4	of	of	ADP
biomedich-119	277	5	type	type	NOUN
biomedich-119	277	6	1	1	NUM
biomedich-119	277	7	diabetes	diabetes	NOUN
biomedich-119	277	8	by	by	ADP
biomedich-119	277	9	gene	gene	NOUN
biomedich-119	277	10	therapy	therapy	NOUN
biomedich-119	277	11	using	use	VERB
biomedich-119	277	12	a	a	DET
biomedich-119	277	13	single	single	ADJ
biomedich-119	277	14	-	-	PUNCT
biomedich-119	277	15	chain	chain	NOUN
biomedich-119	277	16	insulin	insulin	NOUN
biomedich-119	277	17	analogue	analogue	NOUN
biomedich-119	277	18	.	.	PUNCT
biomedich-119	278	1	nature	nature	NOUN
biomedich-119	278	2	,	,	PUNCT
biomedich-119	278	3	408(6811	408(6811	NUM
biomedich-119	278	4	)	)	PUNCT
biomedich-119	278	5	,	,	PUNCT
biomedich-119	278	6	pp.483	pp.483	PROPN
biomedich-119	278	7	-	-	PUNCT
biomedich-119	278	8	488	488	NUM
biomedich-119	278	9	.	.	PUNCT
biomedich-119	279	1	liu	liu	PROPN
biomedich-119	279	2	,	,	PUNCT
biomedich-119	279	3	b.	b.	PROPN
biomedich-119	279	4	,	,	PUNCT
biomedich-119	279	5	xiang	xiang	PROPN
biomedich-119	279	6	,	,	PUNCT
biomedich-119	279	7	y.	y.	PROPN
biomedich-119	279	8	,	,	PUNCT
biomedich-119	279	9	liu	liu	PROPN
biomedich-119	279	10	,	,	PUNCT
biomedich-119	279	11	z.	z.	PROPN
biomedich-119	279	12	and	and	CCONJ
biomedich-119	279	13	zhou	zhou	PROPN
biomedich-119	279	14	,	,	PUNCT
biomedich-119	279	15	z.	z.	PROPN
biomedich-119	279	16	,	,	PUNCT
biomedich-119	279	17	2020	2020	NUM
biomedich-119	279	18	.	.	PUNCT
biomedich-119	280	1	past	past	ADJ
biomedich-119	280	2	,	,	PUNCT
biomedich-119	280	3	present	present	ADJ
biomedich-119	280	4	and	and	CCONJ
biomedich-119	280	5	future	future	NOUN
biomedich-119	280	6	of	of	ADP
biomedich-119	280	7	latent	latent	ADJ
biomedich-119	280	8	autoimmune	autoimmune	ADJ
biomedich-119	280	9	diabetes	diabetes	NOUN
biomedich-119	280	10	in	in	ADP
biomedich-119	280	11	adults	adult	NOUN
biomedich-119	280	12	.	.	PUNCT
biomedich-119	281	1	diabetes	diabetes	NOUN
biomedich-119	281	2	/	/	SYM
biomedich-119	281	3	metabolism	metabolism	NOUN
biomedich-119	281	4	research	research	NOUN
biomedich-119	281	5	and	and	CCONJ
biomedich-119	281	6	reviews	review	NOUN
biomedich-119	281	7	,	,	PUNCT
biomedich-119	281	8	36(1	36(1	NUM
biomedich-119	281	9	)	)	PUNCT
biomedich-119	281	10	,	,	PUNCT
biomedich-119	281	11	p.e3205	p.e3205	PROPN
biomedich-119	281	12	.	.	PROPN
biomedich-119	281	13	lu	lu	PROPN
biomedich-119	281	14	,	,	PUNCT
biomedich-119	281	15	y.	y.	PROPN
biomedich-119	281	16	,	,	PUNCT
biomedich-119	281	17	tang	tang	PROPN
biomedich-119	281	18	,	,	PUNCT
biomedich-119	281	19	m.	m.	NOUN
biomedich-119	281	20	,	,	PUNCT
biomedich-119	281	21	wasserfall	wasserfall	PROPN
biomedich-119	281	22	,	,	PUNCT
biomedich-119	281	23	c.	c.	PROPN
biomedich-119	281	24	,	,	PUNCT
biomedich-119	281	25	kou	kou	PROPN
biomedich-119	281	26	,	,	PUNCT
biomedich-119	281	27	z.	z.	PROPN
biomedich-119	281	28	,	,	PUNCT
biomedich-119	281	29	campbell	campbell	PROPN
biomedich-119	281	30	-	-	PUNCT
biomedich-119	281	31	thompson	thompson	PROPN
biomedich-119	281	32	,	,	PUNCT
biomedich-119	281	33	m.	m.	NOUN
biomedich-119	281	34	,	,	PUNCT
biomedich-119	281	35	gardemann	gardemann	NOUN
biomedich-119	281	36	,	,	PUNCT
biomedich-119	281	37	t.	t.	PROPN
biomedich-119	281	38	,	,	PUNCT
biomedich-119	281	39	crawford	crawford	PROPN
biomedich-119	281	40	,	,	PUNCT
biomedich-119	281	41	j.	j.	PROPN
biomedich-119	281	42	,	,	PUNCT
biomedich-119	281	43	atkinson	atkinson	PROPN
biomedich-119	281	44	,	,	PUNCT
biomedich-119	281	45	m.	m.	NOUN
biomedich-119	281	46	and	and	CCONJ
biomedich-119	281	47	song	song	NOUN
biomedich-119	281	48	,	,	PUNCT
biomedich-119	281	49	s.	s.	PROPN
biomedich-119	281	50	,	,	PUNCT
biomedich-119	281	51	2006	2006	NUM
biomedich-119	281	52	.	.	PUNCT
biomedich-119	282	1	α	α	DET
biomedich-119	282	2	1	1	NUM
biomedich-119	282	3	-	-	PUNCT
biomedich-119	282	4	antitrypsin	antitrypsin	NOUN
biomedich-119	282	5	gene	gene	NOUN
biomedich-119	282	6	therapy	therapy	NOUN
biomedich-119	282	7	modulates	modulate	VERB
biomedich-119	282	8	cellular	cellular	ADJ
biomedich-119	282	9	immunity	immunity	NOUN
biomedich-119	282	10	and	and	CCONJ
biomedich-119	282	11	efficiently	efficiently	ADV
biomedich-119	282	12	prevents	prevent	VERB
biomedich-119	282	13	type	type	NOUN
biomedich-119	282	14	1	1	NUM
biomedich-119	282	15	diabetes	diabetes	NOUN
biomedich-119	282	16	in	in	ADP
biomedich-119	282	17	nonobese	nonobese	ADJ
biomedich-119	282	18	diabetic	diabetic	ADJ
biomedich-119	282	19	mice	mouse	NOUN
biomedich-119	282	20	.	.	PUNCT
biomedich-119	283	1	human	human	ADJ
biomedich-119	283	2	gene	gene	NOUN
biomedich-119	283	3	therapy	therapy	NOUN
biomedich-119	283	4	,	,	PUNCT
biomedich-119	283	5	17(6	17(6	NUM
biomedich-119	283	6	)	)	PUNCT
biomedich-119	283	7	,	,	PUNCT
biomedich-119	283	8	pp.625	pp.625	PROPN
biomedich-119	283	9	-	-	PUNCT
biomedich-119	283	10	634	634	NUM
biomedich-119	283	11	.	.	PUNCT
biomedich-119	284	1	maanaoui	maanaoui	NOUN
biomedich-119	284	2	,	,	PUNCT
biomedich-119	284	3	m.	m.	NOUN
biomedich-119	284	4	,	,	PUNCT
biomedich-119	284	5	chetboun	chetboun	PROPN
biomedich-119	284	6	,	,	PUNCT
biomedich-119	284	7	m.	m.	NOUN
biomedich-119	284	8	,	,	PUNCT
biomedich-119	284	9	kerr	kerr	PROPN
biomedich-119	284	10	-	-	PUNCT
biomedich-119	284	11	conte	conte	PROPN
biomedich-119	284	12	,	,	PUNCT
biomedich-119	284	13	j.	j.	PROPN
biomedich-119	284	14	,	,	PUNCT
biomedich-119	284	15	gmyr	gmyr	NOUN
biomedich-119	284	16	,	,	PUNCT
biomedich-119	284	17	v.	v.	PROPN
biomedich-119	284	18	,	,	PUNCT
biomedich-119	284	19	hubert	hubert	PROPN
biomedich-119	284	20	,	,	PUNCT
biomedich-119	284	21	t.	t.	PROPN
biomedich-119	284	22	,	,	PUNCT
biomedich-119	284	23	caiazzo	caiazzo	PROPN
biomedich-119	284	24	,	,	PUNCT
biomedich-119	284	25	r.	r.	PROPN
biomedich-119	284	26	,	,	PUNCT
biomedich-119	284	27	jannin	jannin	PROPN
biomedich-119	284	28	,	,	PUNCT
biomedich-119	284	29	a.	a.	NOUN
biomedich-119	284	30	,	,	PUNCT
biomedich-119	284	31	le	le	X
biomedich-119	284	32	mapihan	mapihan	NOUN
biomedich-119	284	33	,	,	PUNCT
biomedich-119	284	34	k.	k.	PROPN
biomedich-119	284	35	,	,	PUNCT
biomedich-119	284	36	vantyghem	vantyghem	PROPN
biomedich-119	284	37	,	,	PUNCT
biomedich-119	284	38	m.c	m.c	PROPN
biomedich-119	284	39	.	.	PROPN
biomedich-119	284	40	,	,	PUNCT
biomedich-119	284	41	hazzan	hazzan	PROPN
biomedich-119	284	42	,	,	PUNCT
biomedich-119	284	43	m.	m.	NOUN
biomedich-119	284	44	and	and	CCONJ
biomedich-119	284	45	pattou	pattou	PROPN
biomedich-119	284	46	,	,	PUNCT
biomedich-119	284	47	f.	f.	PROPN
biomedich-119	284	48	,	,	PUNCT
biomedich-119	284	49	2020	2020	NUM
biomedich-119	284	50	.	.	PUNCT
biomedich-119	285	1	p1672	p1672	PROPN
biomedich-119	285	2	impact	impact	NOUN
biomedich-119	285	3	of	of	ADP
biomedich-119	285	4	islet	islet	NOUN
biomedich-119	285	5	transplantation	transplantation	NOUN
biomedich-119	285	6	versus	versus	ADP
biomedich-119	285	7	insulin	insulin	NOUN
biomedich-119	285	8	alone	alone	ADV
biomedich-119	285	9	after	after	ADP
biomedich-119	285	10	kidney	kidney	NOUN
biomedich-119	285	11	transplantation	transplantation	NOUN
biomedich-119	285	12	in	in	ADP
biomedich-119	285	13	type	type	NOUN
biomedich-119	285	14	1	1	NUM
biomedich-119	285	15	diabetes	diabetes	NOUN
biomedich-119	285	16	patients	patient	NOUN
biomedich-119	285	17	.	.	PUNCT
biomedich-119	286	1	nephrology	nephrology	NOUN
biomedich-119	286	2	dialysis	dialysis	NOUN
biomedich-119	286	3	transplantation	transplantation	NOUN
biomedich-119	286	4	,	,	PUNCT
biomedich-119	286	5	35(supplement_3	35(supplement_3	NUM
biomedich-119	286	6	)	)	PUNCT
biomedich-119	286	7	,	,	PUNCT
biomedich-119	286	8	pp.gfaa142	pp.gfaa142	NOUN
biomedich-119	286	9	-	-	PUNCT
biomedich-119	286	10	p1672	p1672	NOUN
biomedich-119	286	11	.	.	PUNCT
biomedich-119	287	1	maffi	maffi	ADV
biomedich-119	287	2	,	,	PUNCT
biomedich-119	287	3	p.	p.	PROPN
biomedich-119	287	4	,	,	PUNCT
biomedich-119	287	5	lundgren	lundgren	PROPN
biomedich-119	287	6	,	,	PUNCT
biomedich-119	287	7	t.	t.	PROPN
biomedich-119	287	8	,	,	PUNCT
biomedich-119	287	9	tufveson	tufveson	PROPN
biomedich-119	287	10	,	,	PUNCT
biomedich-119	287	11	g.	g.	PROPN
biomedich-119	287	12	,	,	PUNCT
biomedich-119	287	13	rafael	rafael	PROPN
biomedich-119	287	14	,	,	PUNCT
biomedich-119	287	15	e.	e.	PROPN
biomedich-119	287	16	,	,	PUNCT
biomedich-119	287	17	shaw	shaw	PROPN
biomedich-119	287	18	,	,	PUNCT
biomedich-119	287	19	j.a	j.a	PROPN
biomedich-119	287	20	.	.	PROPN
biomedich-119	287	21	,	,	PUNCT
biomedich-119	287	22	liew	liew	PROPN
biomedich-119	287	23	,	,	PUNCT
biomedich-119	287	24	a.	a.	NOUN
biomedich-119	287	25	,	,	PUNCT
biomedich-119	287	26	saudek	saudek	NOUN
biomedich-119	287	27	,	,	PUNCT
biomedich-119	287	28	f.	f.	PROPN
biomedich-119	287	29	,	,	PUNCT
biomedich-119	287	30	witkowski	witkowski	ADJ
biomedich-119	287	31	,	,	PUNCT
biomedich-119	287	32	p.	p.	NOUN
biomedich-119	287	33	,	,	PUNCT
biomedich-119	287	34	golab	golab	PROPN
biomedich-119	287	35	,	,	PUNCT
biomedich-119	287	36	k.	k.	PROPN
biomedich-119	287	37	,	,	PUNCT
biomedich-119	287	38	bertuzzi	bertuzzi	PROPN
biomedich-119	287	39	,	,	PUNCT
biomedich-119	287	40	f.	f.	PROPN
biomedich-119	287	41	and	and	CCONJ
biomedich-119	287	42	gustafsson	gustafsson	PROPN
biomedich-119	287	43	,	,	PUNCT
biomedich-119	287	44	b.	b.	PROPN
biomedich-119	287	45	,	,	PUNCT
biomedich-119	287	46	2020	2020	NUM
biomedich-119	287	47	.	.	PUNCT
biomedich-119	288	1	targeting	target	VERB
biomedich-119	288	2	cxcr1/2	cxcr1/2	NOUN
biomedich-119	288	3	does	do	AUX
biomedich-119	288	4	not	not	PART
biomedich-119	288	5	improve	improve	VERB
biomedich-119	288	6	insulin	insulin	NOUN
biomedich-119	288	7	secretion	secretion	NOUN
biomedich-119	288	8	after	after	ADP
biomedich-119	288	9	pancreatic	pancreatic	ADJ
biomedich-119	288	10	islet	islet	NOUN
biomedich-119	288	11	transplantation	transplantation	NOUN
biomedich-119	288	12	:	:	PUNCT
biomedich-119	288	13	a	a	DET
biomedich-119	288	14	phase	phase	NOUN
biomedich-119	288	15	3	3	NUM
biomedich-119	288	16	,	,	PUNCT
biomedich-119	288	17	double	double	ADJ
biomedich-119	288	18	-	-	PUNCT
biomedich-119	288	19	blind	blind	ADJ
biomedich-119	288	20	,	,	PUNCT
biomedich-119	288	21	randomized	randomize	VERB
biomedich-119	288	22	,	,	PUNCT
biomedich-119	288	23	placebo	placebo	NOUN
biomedich-119	288	24	-	-	PUNCT
biomedich-119	288	25	controlled	control	VERB
biomedich-119	288	26	trial	trial	NOUN
biomedich-119	288	27	in	in	ADP
biomedich-119	288	28	type	type	NOUN
biomedich-119	288	29	1	1	NUM
biomedich-119	288	30	diabetes	diabetes	NOUN
biomedich-119	288	31	.	.	PUNCT
biomedich-119	289	1	diabetes	diabetes	NOUN
biomedich-119	289	2	care	care	NOUN
biomedich-119	289	3	,	,	PUNCT
biomedich-119	289	4	43(4	43(4	NOUN
biomedich-119	289	5	)	)	PUNCT
biomedich-119	289	6	,	,	PUNCT
biomedich-119	289	7	pp.710	pp.710	PROPN
biomedich-119	289	8	-	-	SYM
biomedich-119	289	9	718	718	NUM
biomedich-119	289	10	.	.	PUNCT
biomedich-119	290	1	matsumoto	matsumoto	PROPN
biomedich-119	290	2	,	,	PUNCT
biomedich-119	290	3	s.	s.	PROPN
biomedich-119	290	4	,	,	PUNCT
biomedich-119	290	5	2010	2010	NUM
biomedich-119	290	6	.	.	PUNCT
biomedich-119	291	1	islet	islet	NOUN
biomedich-119	291	2	cell	cell	NOUN
biomedich-119	291	3	transplantation	transplantation	NOUN
biomedich-119	291	4	for	for	ADP
biomedich-119	291	5	type	type	NOUN
biomedich-119	291	6	1	1	NUM
biomedich-119	291	7	diabetes	diabetes	NOUN
biomedich-119	291	8	.	.	PUNCT
biomedich-119	292	1	journal	journal	NOUN
biomedich-119	292	2	of	of	ADP
biomedich-119	292	3	diabetes	diabetes	NOUN
biomedich-119	292	4	,	,	PUNCT
biomedich-119	292	5	2(1	2(1	NUM
biomedich-119	292	6	)	)	PUNCT
biomedich-119	292	7	,	,	PUNCT
biomedich-119	292	8	pp.16	pp.16	PROPN
biomedich-119	292	9	-	-	PUNCT
biomedich-119	292	10	22	22	PROPN
biomedich-119	292	11	.	.	PUNCT
biomedich-119	293	1	maxwell	maxwell	PROPN
biomedich-119	293	2	,	,	PUNCT
biomedich-119	293	3	k.g	k.g	PROPN
biomedich-119	293	4	.	.	PROPN
biomedich-119	293	5	,	,	PUNCT
biomedich-119	293	6	augsornworawat	augsornworawat	VERB
biomedich-119	293	7	,	,	PUNCT
biomedich-119	293	8	p.	p.	NOUN
biomedich-119	293	9	,	,	PUNCT
biomedich-119	293	10	velazco	velazco	NOUN
biomedich-119	293	11	-	-	PUNCT
biomedich-119	293	12	cruz	cruz	NOUN
biomedich-119	293	13	,	,	PUNCT
biomedich-119	293	14	l.	l.	PROPN
biomedich-119	293	15	,	,	PUNCT
biomedich-119	293	16	kim	kim	PROPN
biomedich-119	293	17	,	,	PUNCT
biomedich-119	293	18	m.h	m.h	PROPN
biomedich-119	293	19	.	.	PROPN
biomedich-119	293	20	,	,	PUNCT
biomedich-119	293	21	asada	asada	PROPN
biomedich-119	293	22	,	,	PUNCT
biomedich-119	293	23	r.	r.	PROPN
biomedich-119	293	24	,	,	PUNCT
biomedich-119	293	25	hogrebe	hogrebe	NOUN
biomedich-119	293	26	,	,	PUNCT
biomedich-119	293	27	n.j	n.j	PROPN
biomedich-119	293	28	.	.	PROPN
biomedich-119	293	29	,	,	PUNCT
biomedich-119	293	30	morikawa	morikawa	PROPN
biomedich-119	293	31	,	,	PUNCT
biomedich-119	293	32	s.	s.	PROPN
biomedich-119	293	33	,	,	PUNCT
biomedich-119	293	34	urano	urano	PROPN
biomedich-119	293	35	,	,	PUNCT
biomedich-119	293	36	f.	f.	PROPN
biomedich-119	293	37	and	and	CCONJ
biomedich-119	293	38	millman	millman	PROPN
biomedich-119	293	39	,	,	PUNCT
biomedich-119	293	40	j.r	j.r	PROPN
biomedich-119	293	41	.	.	PROPN
biomedich-119	293	42	,	,	PUNCT
biomedich-119	293	43	2020	2020	NUM
biomedich-119	293	44	.	.	PUNCT
biomedich-119	294	1	gene	gene	NOUN
biomedich-119	294	2	-	-	PUNCT
biomedich-119	294	3	edited	edit	VERB
biomedich-119	294	4	human	human	ADJ
biomedich-119	294	5	stem	stem	NOUN
biomedich-119	294	6	cell	cell	NOUN
biomedich-119	294	7	–	–	PUNCT
biomedich-119	294	8	derived	derive	VERB
biomedich-119	294	9	β	β	X
biomedich-119	294	10	cells	cell	NOUN
biomedich-119	294	11	from	from	ADP
biomedich-119	294	12	a	a	DET
biomedich-119	294	13	patient	patient	NOUN
biomedich-119	294	14	with	with	ADP
biomedich-119	294	15	monogenic	monogenic	ADJ
biomedich-119	294	16	diabetes	diabetes	NOUN
biomedich-119	294	17	reverse	reverse	VERB
biomedich-119	294	18	preexisting	preexist	VERB
biomedich-119	294	19	diabetes	diabetes	NOUN
biomedich-119	294	20	in	in	ADP
biomedich-119	294	21	mice	mouse	NOUN
biomedich-119	294	22	.	.	PUNCT
biomedich-119	295	1	science	science	NOUN
biomedich-119	295	2	translational	translational	ADJ
biomedich-119	295	3	medicine	medicine	NOUN
biomedich-119	295	4	,	,	PUNCT
biomedich-119	295	5	12(540	12(540	NUM
biomedich-119	295	6	)	)	PUNCT
biomedich-119	295	7	.	.	PUNCT
biomedich-119	296	1	memon	memon	PROPN
biomedich-119	296	2	,	,	PUNCT
biomedich-119	296	3	b.	b.	PROPN
biomedich-119	296	4	and	and	CCONJ
biomedich-119	296	5	abdelalim	abdelalim	PROPN
biomedich-119	296	6	,	,	PUNCT
biomedich-119	296	7	e.m	e.m	PROPN
biomedich-119	296	8	.	.	PROPN
biomedich-119	296	9	,	,	PUNCT
biomedich-119	296	10	2020	2020	NUM
biomedich-119	296	11	.	.	PUNCT
biomedich-119	297	1	stem	stem	NOUN
biomedich-119	297	2	cell	cell	NOUN
biomedich-119	297	3	therapy	therapy	NOUN
biomedich-119	297	4	for	for	ADP
biomedich-119	297	5	diabetes	diabetes	NOUN
biomedich-119	297	6	:	:	PUNCT
biomedich-119	297	7	beta	beta	ADJ
biomedich-119	297	8	cells	cell	NOUN
biomedich-119	297	9	versus	versus	ADP
biomedich-119	297	10	pancreatic	pancreatic	ADJ
biomedich-119	297	11	progenitors	progenitor	NOUN
biomedich-119	297	12	.	.	PUNCT
biomedich-119	298	1	cells	cell	NOUN
biomedich-119	298	2	,	,	PUNCT
biomedich-119	298	3	9(2	9(2	NUM
biomedich-119	298	4	)	)	PUNCT
biomedich-119	298	5	,	,	PUNCT
biomedich-119	298	6	p.283	p.283	X
biomedich-119	298	7	.	.	PUNCT
biomedich-119	299	1	smail	smail	NOUN
biomedich-119	299	2	–	–	PUNCT
biomedich-119	299	3	the	the	DET
biomedich-119	299	4	role	role	NOUN
biomedich-119	299	5	of	of	ADP
biomedich-119	299	6	gene	gene	NOUN
biomedich-119	299	7	therapy	therapy	NOUN
biomedich-119	299	8	in	in	ADP
biomedich-119	299	9	the	the	DET
biomedich-119	299	10	treatments	treatment	NOUN
biomedich-119	299	11	of	of	ADP
biomedich-119	299	12	…	…	PUNCT
biomedich-119	299	13	63	63	NUM
biomedich-119	299	14	naldini	naldini	NOUN
biomedich-119	299	15	,	,	PUNCT
biomedich-119	299	16	l.	l.	PROPN
biomedich-119	299	17	,	,	PUNCT
biomedich-119	299	18	2015	2015	NUM
biomedich-119	299	19	.	.	PUNCT
biomedich-119	300	1	gene	gene	NOUN
biomedich-119	300	2	therapy	therapy	NOUN
biomedich-119	300	3	returns	return	VERB
biomedich-119	300	4	to	to	ADP
biomedich-119	300	5	centre	centre	NOUN
biomedich-119	300	6	stage	stage	NOUN
biomedich-119	300	7	.	.	PUNCT
biomedich-119	301	1	nature	nature	NOUN
biomedich-119	301	2	,	,	PUNCT
biomedich-119	301	3	526(7573	526(7573	NUM
biomedich-119	301	4	)	)	PUNCT
biomedich-119	301	5	,	,	PUNCT
biomedich-119	301	6	pp.351	pp.351	NOUN
biomedich-119	301	7	-	-	PUNCT
biomedich-119	301	8	360	360	NUM
biomedich-119	301	9	.	.	PUNCT
biomedich-119	302	1	niu	niu	PROPN
biomedich-119	302	2	,	,	PUNCT
biomedich-119	302	3	l.	l.	PROPN
biomedich-119	302	4	,	,	PUNCT
biomedich-119	302	5	xu	xu	PROPN
biomedich-119	302	6	,	,	PUNCT
biomedich-119	302	7	y.c	y.c	PROPN
biomedich-119	302	8	.	.	PROPN
biomedich-119	302	9	,	,	PUNCT
biomedich-119	302	10	dai	dai	PROPN
biomedich-119	302	11	,	,	PUNCT
biomedich-119	302	12	z.	z.	PROPN
biomedich-119	302	13	and	and	CCONJ
biomedich-119	302	14	tang	tang	PROPN
biomedich-119	302	15	,	,	PUNCT
biomedich-119	302	16	h.q	h.q	PROPN
biomedich-119	302	17	.	.	PROPN
biomedich-119	302	18	,	,	PUNCT
biomedich-119	302	19	2008	2008	NUM
biomedich-119	302	20	.	.	PUNCT
biomedich-119	303	1	gene	gene	NOUN
biomedich-119	303	2	therapy	therapy	NOUN
biomedich-119	303	3	for	for	ADP
biomedich-119	303	4	type	type	NOUN
biomedich-119	303	5	1	1	NUM
biomedich-119	303	6	diabetes	diabetes	NOUN
biomedich-119	303	7	mellitus	mellitus	NOUN
biomedich-119	303	8	in	in	ADP
biomedich-119	303	9	rats	rat	NOUN
biomedich-119	303	10	by	by	ADP
biomedich-119	303	11	gastrointestinal	gastrointestinal	ADJ
biomedich-119	303	12	administration	administration	NOUN
biomedich-119	303	13	of	of	ADP
biomedich-119	303	14	chitosan	chitosan	ADJ
biomedich-119	303	15	nanoparticles	nanoparticle	NOUN
biomedich-119	303	16	containing	contain	VERB
biomedich-119	303	17	human	human	ADJ
biomedich-119	303	18	insulin	insulin	NOUN
biomedich-119	303	19	gene	gene	NOUN
biomedich-119	303	20	.	.	PUNCT
biomedich-119	304	1	world	world	PROPN
biomedich-119	304	2	journal	journal	PROPN
biomedich-119	304	3	of	of	ADP
biomedich-119	304	4	gastroenterology	gastroenterology	NOUN
biomedich-119	304	5	:	:	PUNCT
biomedich-119	304	6	wjg	wjg	VERB
biomedich-119	304	7	,	,	PUNCT
biomedich-119	304	8	14(26	14(26	NUM
biomedich-119	304	9	)	)	PUNCT
biomedich-119	304	10	,	,	PUNCT
biomedich-119	304	11	p.4209	p.4209	NOUN
biomedich-119	304	12	.	.	PUNCT
biomedich-119	305	1	onuma	onuma	ADJ
biomedich-119	305	2	,	,	PUNCT
biomedich-119	305	3	h.	h.	PROPN
biomedich-119	305	4	,	,	PUNCT
biomedich-119	305	5	kawamura	kawamura	PROPN
biomedich-119	305	6	,	,	PUNCT
biomedich-119	305	7	r.	r.	PROPN
biomedich-119	305	8	,	,	PUNCT
biomedich-119	305	9	tabara	tabara	PROPN
biomedich-119	305	10	,	,	PUNCT
biomedich-119	305	11	y.	y.	PROPN
biomedich-119	305	12	,	,	PUNCT
biomedich-119	305	13	yamashita	yamashita	PROPN
biomedich-119	305	14	,	,	PUNCT
biomedich-119	305	15	m.	m.	NOUN
biomedich-119	305	16	,	,	PUNCT
biomedich-119	305	17	ohashi	ohashi	PROPN
biomedich-119	305	18	,	,	PUNCT
biomedich-119	305	19	j.	j.	PROPN
biomedich-119	305	20	,	,	PUNCT
biomedich-119	305	21	kawasaki	kawasaki	PROPN
biomedich-119	305	22	,	,	PUNCT
biomedich-119	305	23	e.	e.	PROPN
biomedich-119	305	24	,	,	PUNCT
biomedich-119	305	25	imagawa	imagawa	PROPN
biomedich-119	305	26	,	,	PUNCT
biomedich-119	305	27	a.	a.	PROPN
biomedich-119	305	28	,	,	PUNCT
biomedich-119	305	29	yamada	yamada	PROPN
biomedich-119	305	30	,	,	PUNCT
biomedich-119	305	31	y.	y.	PROPN
biomedich-119	305	32	,	,	PUNCT
biomedich-119	305	33	chujo	chujo	PROPN
biomedich-119	305	34	,	,	PUNCT
biomedich-119	305	35	d.	d.	PROPN
biomedich-119	305	36	,	,	PUNCT
biomedich-119	305	37	takahashi	takahashi	PROPN
biomedich-119	305	38	,	,	PUNCT
biomedich-119	305	39	k.	k.	PROPN
biomedich-119	305	40	and	and	CCONJ
biomedich-119	305	41	suehiro	suehiro	PROPN
biomedich-119	305	42	,	,	PUNCT
biomedich-119	305	43	t.	t.	PROPN
biomedich-119	305	44	,	,	PUNCT
biomedich-119	305	45	2019	2019	NUM
biomedich-119	305	46	.	.	PUNCT
biomedich-119	306	1	variants	variant	NOUN
biomedich-119	306	2	in	in	ADP
biomedich-119	306	3	the	the	DET
biomedich-119	306	4	bach2	bach2	NOUN
biomedich-119	306	5	and	and	CCONJ
biomedich-119	306	6	clec16a	clec16a	PROPN
biomedich-119	306	7	gene	gene	NOUN
biomedich-119	306	8	might	might	AUX
biomedich-119	306	9	be	be	AUX
biomedich-119	306	10	associated	associate	VERB
biomedich-119	306	11	with	with	ADP
biomedich-119	306	12	susceptibility	susceptibility	NOUN
biomedich-119	306	13	to	to	ADP
biomedich-119	306	14	insulin‐triggered	insulin‐triggered	ADJ
biomedich-119	306	15	type	type	NOUN
biomedich-119	306	16	1	1	NUM
biomedich-119	306	17	diabetes	diabetes	NOUN
biomedich-119	306	18	.	.	PUNCT
biomedich-119	307	1	journal	journal	NOUN
biomedich-119	307	2	of	of	ADP
biomedich-119	307	3	diabetes	diabetes	PROPN
biomedich-119	307	4	investigation	investigation	NOUN
biomedich-119	307	5	,	,	PUNCT
biomedich-119	307	6	10(6	10(6	PROPN
biomedich-119	307	7	)	)	PUNCT
biomedich-119	307	8	,	,	PUNCT
biomedich-119	307	9	pp.1447	pp.1447	PROPN
biomedich-119	307	10	-	-	PUNCT
biomedich-119	307	11	1453	1453	NUM
biomedich-119	307	12	.	.	PUNCT
biomedich-119	308	1	paty	paty	NOUN
biomedich-119	308	2	,	,	PUNCT
biomedich-119	308	3	b.w	b.w	PROPN
biomedich-119	308	4	.	.	PROPN
biomedich-119	308	5	,	,	PUNCT
biomedich-119	308	6	ryan	ryan	PROPN
biomedich-119	308	7	,	,	PUNCT
biomedich-119	308	8	e.a	e.a	PROPN
biomedich-119	308	9	.	.	PROPN
biomedich-119	308	10	,	,	PUNCT
biomedich-119	308	11	shapiro	shapiro	PROPN
biomedich-119	308	12	,	,	PUNCT
biomedich-119	308	13	a.j	a.j	PROPN
biomedich-119	308	14	.	.	PROPN
biomedich-119	308	15	,	,	PUNCT
biomedich-119	308	16	lakey	lakey	PROPN
biomedich-119	308	17	,	,	PUNCT
biomedich-119	308	18	j.r	j.r	PROPN
biomedich-119	308	19	.	.	PROPN
biomedich-119	308	20	and	and	CCONJ
biomedich-119	308	21	robertson	robertson	PROPN
biomedich-119	308	22	,	,	PUNCT
biomedich-119	308	23	r.p	r.p	PROPN
biomedich-119	308	24	.	.	PROPN
biomedich-119	308	25	,	,	PUNCT
biomedich-119	308	26	2002	2002	NUM
biomedich-119	308	27	.	.	PUNCT
biomedich-119	309	1	intrahepatic	intrahepatic	ADJ
biomedich-119	309	2	islet	islet	NOUN
biomedich-119	309	3	transplantation	transplantation	NOUN
biomedich-119	309	4	in	in	ADP
biomedich-119	309	5	type	type	NOUN
biomedich-119	309	6	1	1	NUM
biomedich-119	309	7	diabetic	diabetic	ADJ
biomedich-119	309	8	patients	patient	NOUN
biomedich-119	309	9	does	do	AUX
biomedich-119	309	10	not	not	PART
biomedich-119	309	11	restore	restore	VERB
biomedich-119	309	12	hypoglycemic	hypoglycemic	ADJ
biomedich-119	309	13	hormonal	hormonal	ADJ
biomedich-119	309	14	counterregulation	counterregulation	NOUN
biomedich-119	309	15	or	or	CCONJ
biomedich-119	309	16	symptom	symptom	NOUN
biomedich-119	309	17	recognition	recognition	NOUN
biomedich-119	309	18	after	after	ADP
biomedich-119	309	19	insulin	insulin	NOUN
biomedich-119	309	20	independence	independence	NOUN
biomedich-119	309	21	.	.	PUNCT
biomedich-119	310	1	diabetes	diabetes	NOUN
biomedich-119	310	2	,	,	PUNCT
biomedich-119	310	3	51(12	51(12	NUM
biomedich-119	310	4	)	)	PUNCT
biomedich-119	310	5	,	,	PUNCT
biomedich-119	310	6	pp.3428	pp.3428	PROPN
biomedich-119	310	7	-	-	PUNCT
biomedich-119	310	8	3434	3434	NUM
biomedich-119	310	9	.	.	PUNCT
biomedich-119	311	1	prud'homme	prud'homme	PROPN
biomedich-119	311	2	,	,	PUNCT
biomedich-119	311	3	g.j	g.j	PROPN
biomedich-119	311	4	.	.	PROPN
biomedich-119	311	5	,	,	PUNCT
biomedich-119	311	6	draghia	draghia	NOUN
biomedich-119	311	7	-	-	PUNCT
biomedich-119	311	8	akli	akli	PROPN
biomedich-119	311	9	,	,	PUNCT
biomedich-119	311	10	r.	r.	PROPN
biomedich-119	311	11	and	and	CCONJ
biomedich-119	311	12	wang	wang	PROPN
biomedich-119	311	13	,	,	PUNCT
biomedich-119	311	14	q.	q.	PROPN
biomedich-119	311	15	,	,	PUNCT
biomedich-119	311	16	2007	2007	NUM
biomedich-119	311	17	.	.	PUNCT
biomedich-119	312	1	plasmid	plasmid	NOUN
biomedich-119	312	2	-	-	PUNCT
biomedich-119	312	3	based	base	VERB
biomedich-119	312	4	gene	gene	NOUN
biomedich-119	312	5	therapy	therapy	NOUN
biomedich-119	312	6	of	of	ADP
biomedich-119	312	7	diabetes	diabetes	NOUN
biomedich-119	312	8	mellitus	mellitus	NOUN
biomedich-119	312	9	.	.	PUNCT
biomedich-119	313	1	gene	gene	NOUN
biomedich-119	313	2	therapy	therapy	NOUN
biomedich-119	313	3	,	,	PUNCT
biomedich-119	313	4	14(7	14(7	NUM
biomedich-119	313	5	)	)	PUNCT
biomedich-119	313	6	,	,	PUNCT
biomedich-119	313	7	pp.553	pp.553	PROPN
biomedich-119	313	8	-	-	SYM
biomedich-119	313	9	564	564	NUM
biomedich-119	313	10	.	.	PUNCT
biomedich-119	314	1	ramezani	ramezani	PROPN
biomedich-119	314	2	,	,	PUNCT
biomedich-119	314	3	k.	k.	PROPN
biomedich-119	314	4	,	,	PUNCT
biomedich-119	314	5	gheflat	gheflat	PROPN
biomedich-119	314	6	,	,	PUNCT
biomedich-119	314	7	s.	s.	PROPN
biomedich-119	314	8	,	,	PUNCT
biomedich-119	314	9	jajarmi	jajarmi	PROPN
biomedich-119	314	10	,	,	PUNCT
biomedich-119	314	11	v.	v.	ADV
biomedich-119	314	12	,	,	PUNCT
biomedich-119	314	13	bandehpour	bandehpour	NOUN
biomedich-119	314	14	,	,	PUNCT
biomedich-119	314	15	m.	m.	NOUN
biomedich-119	314	16	and	and	CCONJ
biomedich-119	314	17	kazemi	kazemi	PROPN
biomedich-119	314	18	,	,	PUNCT
biomedich-119	314	19	b.	b.	PROPN
biomedich-119	314	20	,	,	PUNCT
biomedich-119	314	21	2019	2019	NUM
biomedich-119	314	22	.	.	PUNCT
biomedich-119	315	1	the	the	DET
biomedich-119	315	2	study	study	NOUN
biomedich-119	315	3	on	on	ADP
biomedich-119	315	4	possible	possible	ADJ
biomedich-119	315	5	gene	gene	NOUN
biomedich-119	315	6	therapy	therapy	NOUN
biomedich-119	315	7	on	on	ADP
biomedich-119	315	8	diabetics	diabetic	NOUN
biomedich-119	315	9	type	type	NOUN
biomedich-119	315	10	i	i	PRON
biomedich-119	315	11	using	use	VERB
biomedich-119	315	12	insulin	insulin	NOUN
biomedich-119	315	13	gene	gene	NOUN
biomedich-119	315	14	under	under	ADP
biomedich-119	315	15	control	control	NOUN
biomedich-119	315	16	of	of	ADP
biomedich-119	315	17	heat	heat	NOUN
biomedich-119	315	18	shock	shock	NOUN
biomedich-119	315	19	promoter	promoter	NOUN
biomedich-119	315	20	in	in	ADP
biomedich-119	315	21	laboratory	laboratory	NOUN
biomedich-119	315	22	animals	animal	NOUN
biomedich-119	315	23	.	.	PUNCT
biomedich-119	316	1	novelty	novelty	NOUN
biomedich-119	316	2	in	in	ADP
biomedich-119	316	3	biomedicine	biomedicine	NOUN
biomedich-119	316	4	,	,	PUNCT
biomedich-119	316	5	7(2	7(2	NUM
biomedich-119	316	6	)	)	PUNCT
biomedich-119	316	7	,	,	PUNCT
biomedich-119	316	8	pp.45	pp.45	NOUN
biomedich-119	316	9	-	-	PUNCT
biomedich-119	316	10	48	48	NUM
biomedich-119	316	11	.	.	PUNCT
biomedich-119	317	1	rickels	rickel	NOUN
biomedich-119	317	2	,	,	PUNCT
biomedich-119	317	3	m.r	m.r	PROPN
biomedich-119	317	4	.	.	PROPN
biomedich-119	317	5	,	,	PUNCT
biomedich-119	317	6	schutta	schutta	PROPN
biomedich-119	317	7	,	,	PUNCT
biomedich-119	317	8	m.h	m.h	PROPN
biomedich-119	317	9	.	.	PROPN
biomedich-119	317	10	,	,	PUNCT
biomedich-119	317	11	markmann	markmann	PROPN
biomedich-119	317	12	,	,	PUNCT
biomedich-119	317	13	j.f	j.f	PROPN
biomedich-119	317	14	.	.	PROPN
biomedich-119	317	15	,	,	PUNCT
biomedich-119	317	16	barker	barker	PROPN
biomedich-119	317	17	,	,	PUNCT
biomedich-119	317	18	c.f	c.f	PROPN
biomedich-119	317	19	.	.	PROPN
biomedich-119	317	20	,	,	PUNCT
biomedich-119	317	21	naji	naji	PROPN
biomedich-119	317	22	,	,	PUNCT
biomedich-119	317	23	a.	a.	NOUN
biomedich-119	317	24	and	and	CCONJ
biomedich-119	317	25	teff	teff	NOUN
biomedich-119	317	26	,	,	PUNCT
biomedich-119	317	27	k.l	k.l	PROPN
biomedich-119	317	28	.	.	PROPN
biomedich-119	317	29	,	,	PUNCT
biomedich-119	317	30	2005	2005	NUM
biomedich-119	317	31	.	.	PUNCT
biomedich-119	318	1	β	β	X
biomedich-119	318	2	-	-	PUNCT
biomedich-119	318	3	cell	cell	NOUN
biomedich-119	318	4	function	function	NOUN
biomedich-119	318	5	following	follow	VERB
biomedich-119	318	6	human	human	ADJ
biomedich-119	318	7	islet	islet	NOUN
biomedich-119	318	8	transplantation	transplantation	NOUN
biomedich-119	318	9	for	for	ADP
biomedich-119	318	10	type	type	NOUN
biomedich-119	318	11	1	1	NUM
biomedich-119	318	12	diabetes	diabetes	NOUN
biomedich-119	318	13	.	.	PUNCT
biomedich-119	319	1	diabetes	diabetes	NOUN
biomedich-119	319	2	,	,	PUNCT
biomedich-119	319	3	54(1	54(1	NUM
biomedich-119	319	4	)	)	PUNCT
biomedich-119	319	5	,	,	PUNCT
biomedich-119	319	6	pp.100	pp.100	NOUN
biomedich-119	319	7	-	-	PUNCT
biomedich-119	319	8	106	106	NUM
biomedich-119	319	9	.	.	PUNCT
biomedich-119	320	1	rosado	rosado	NOUN
biomedich-119	320	2	-	-	PUNCT
biomedich-119	320	3	olivieri	olivieri	ADJ
biomedich-119	320	4	,	,	PUNCT
biomedich-119	320	5	e.a	e.a	PROPN
biomedich-119	320	6	.	.	PROPN
biomedich-119	320	7	,	,	PUNCT
biomedich-119	320	8	aigha	aigha	PROPN
biomedich-119	320	9	,	,	PUNCT
biomedich-119	320	10	i.i	i.i	PROPN
biomedich-119	320	11	.	.	PROPN
biomedich-119	320	12	,	,	PUNCT
biomedich-119	320	13	kenty	kenty	PROPN
biomedich-119	320	14	,	,	PUNCT
biomedich-119	320	15	j.h	j.h	PROPN
biomedich-119	320	16	.	.	PROPN
biomedich-119	320	17	and	and	CCONJ
biomedich-119	320	18	melton	melton	PROPN
biomedich-119	320	19	,	,	PUNCT
biomedich-119	320	20	d.a	d.a	PROPN
biomedich-119	320	21	.	.	PROPN
biomedich-119	320	22	,	,	PUNCT
biomedich-119	320	23	2020	2020	NUM
biomedich-119	320	24	.	.	PUNCT
biomedich-119	321	1	identification	identification	NOUN
biomedich-119	321	2	of	of	ADP
biomedich-119	321	3	a	a	DET
biomedich-119	321	4	lif	lif	NOUN
biomedich-119	321	5	-	-	PUNCT
biomedich-119	321	6	responsive	responsive	ADJ
biomedich-119	321	7	,	,	PUNCT
biomedich-119	321	8	replicationcompetent	replicationcompetent	ADJ
biomedich-119	321	9	subpopulation	subpopulation	NOUN
biomedich-119	321	10	of	of	ADP
biomedich-119	321	11	human	human	ADJ
biomedich-119	321	12	β	β	PROPN
biomedich-119	321	13	cells	cell	NOUN
biomedich-119	321	14	.	.	PUNCT
biomedich-119	322	1	cell	cell	NOUN
biomedich-119	322	2	metabolism	metabolism	NOUN
biomedich-119	322	3	,	,	PUNCT
biomedich-119	322	4	31(2	31(2	NUM
biomedich-119	322	5	)	)	PUNCT
biomedich-119	322	6	,	,	PUNCT
biomedich-119	322	7	pp.327	pp.327	PROPN
biomedich-119	322	8	-	-	PUNCT
biomedich-119	322	9	338	338	NUM
biomedich-119	322	10	.	.	PUNCT
biomedich-119	323	1	sachs	sachs	PROPN
biomedich-119	323	2	,	,	PUNCT
biomedich-119	323	3	s.	s.	PROPN
biomedich-119	323	4	,	,	PUNCT
biomedich-119	323	5	bastidas	bastidas	PROPN
biomedich-119	323	6	-	-	PUNCT
biomedich-119	323	7	ponce	ponce	NOUN
biomedich-119	323	8	,	,	PUNCT
biomedich-119	323	9	a.	a.	PROPN
biomedich-119	323	10	,	,	PUNCT
biomedich-119	323	11	tritschler	tritschler	NOUN
biomedich-119	323	12	,	,	PUNCT
biomedich-119	323	13	s.	s.	PROPN
biomedich-119	323	14	,	,	PUNCT
biomedich-119	323	15	bakhti	bakhti	NOUN
biomedich-119	323	16	,	,	PUNCT
biomedich-119	323	17	m.	m.	NOUN
biomedich-119	323	18	,	,	PUNCT
biomedich-119	323	19	böttcher	böttcher	NOUN
biomedich-119	323	20	,	,	PUNCT
biomedich-119	323	21	a.	a.	NOUN
biomedich-119	323	22	,	,	PUNCT
biomedich-119	323	23	sánchez	sánchez	NOUN
biomedich-119	323	24	-	-	PUNCT
biomedich-119	323	25	garrido	garrido	PROPN
biomedich-119	323	26	,	,	PUNCT
biomedich-119	323	27	m.a	m.a	PROPN
biomedich-119	323	28	.	.	PROPN
biomedich-119	323	29	,	,	PUNCT
biomedich-119	323	30	tarquis	tarquis	PROPN
biomedich-119	323	31	-	-	PUNCT
biomedich-119	323	32	medina	medina	PROPN
biomedich-119	323	33	,	,	PUNCT
biomedich-119	323	34	m.	m.	NOUN
biomedich-119	323	35	,	,	PUNCT
biomedich-119	323	36	kleinert	kleinert	PROPN
biomedich-119	323	37	,	,	PUNCT
biomedich-119	323	38	m.	m.	NOUN
biomedich-119	323	39	,	,	PUNCT
biomedich-119	323	40	fischer	fischer	PROPN
biomedich-119	323	41	,	,	PUNCT
biomedich-119	323	42	k.	k.	PROPN
biomedich-119	323	43	,	,	PUNCT
biomedich-119	323	44	jall	jall	PROPN
biomedich-119	323	45	,	,	PUNCT
biomedich-119	323	46	s.	s.	PROPN
biomedich-119	323	47	and	and	CCONJ
biomedich-119	323	48	harger	harger	PROPN
biomedich-119	323	49	,	,	PUNCT
biomedich-119	323	50	a.	a.	NOUN
biomedich-119	323	51	,	,	PUNCT
biomedich-119	323	52	2020	2020	NUM
biomedich-119	323	53	.	.	PUNCT
biomedich-119	324	1	targeted	target	VERB
biomedich-119	324	2	pharmacological	pharmacological	NOUN
biomedich-119	324	3	therapy	therapy	NOUN
biomedich-119	324	4	restores	restore	VERB
biomedich-119	324	5	β	β	NOUN
biomedich-119	324	6	-	-	NOUN
biomedich-119	324	7	cell	cell	NOUN
biomedich-119	324	8	function	function	NOUN
biomedich-119	324	9	for	for	ADP
biomedich-119	324	10	diabetes	diabetes	NOUN
biomedich-119	324	11	remission	remission	NOUN
biomedich-119	324	12	.	.	PUNCT
biomedich-119	325	1	nature	nature	NOUN
biomedich-119	325	2	metabolism	metabolism	NOUN
biomedich-119	325	3	,	,	PUNCT
biomedich-119	325	4	2(2	2(2	NUM
biomedich-119	325	5	)	)	PUNCT
biomedich-119	325	6	,	,	PUNCT
biomedich-119	325	7	pp.192	pp.192	NOUN
biomedich-119	325	8	-	-	PUNCT
biomedich-119	325	9	209	209	NUM
biomedich-119	325	10	.	.	PUNCT
biomedich-119	326	1	samson	samson	PROPN
biomedich-119	326	2	,	,	PUNCT
biomedich-119	326	3	s.l	s.l	PROPN
biomedich-119	326	4	.	.	PROPN
biomedich-119	326	5	and	and	CCONJ
biomedich-119	326	6	chan	chan	PROPN
biomedich-119	326	7	,	,	PUNCT
biomedich-119	326	8	l.	l.	PROPN
biomedich-119	326	9	,	,	PUNCT
biomedich-119	326	10	2006	2006	NUM
biomedich-119	326	11	.	.	PUNCT
biomedich-119	327	1	gene	gene	NOUN
biomedich-119	327	2	therapy	therapy	NOUN
biomedich-119	327	3	for	for	ADP
biomedich-119	327	4	diabetes	diabetes	NOUN
biomedich-119	327	5	:	:	PUNCT
biomedich-119	327	6	reinventing	reinvent	VERB
biomedich-119	327	7	the	the	DET
biomedich-119	327	8	islet	islet	NOUN
biomedich-119	327	9	.	.	PUNCT
biomedich-119	328	1	trends	trend	NOUN
biomedich-119	328	2	in	in	ADP
biomedich-119	328	3	endocrinology	endocrinology	NOUN
biomedich-119	328	4	&	&	CCONJ
biomedich-119	328	5	metabolism	metabolism	NOUN
biomedich-119	328	6	,	,	PUNCT
biomedich-119	328	7	17(3	17(3	NUM
biomedich-119	328	8	)	)	PUNCT
biomedich-119	328	9	,	,	PUNCT
biomedich-119	328	10	pp.92	pp.92	NOUN
biomedich-119	328	11	-	-	PUNCT
biomedich-119	328	12	100	100	NUM
biomedich-119	328	13	.	.	PUNCT
biomedich-119	329	1	scharp	scharp	ADJ
biomedich-119	329	2	,	,	PUNCT
biomedich-119	329	3	d.w	d.w	PROPN
biomedich-119	329	4	.	.	PROPN
biomedich-119	329	5	and	and	CCONJ
biomedich-119	329	6	marchetti	marchetti	PROPN
biomedich-119	329	7	,	,	PUNCT
biomedich-119	329	8	p.	p.	PROPN
biomedich-119	329	9	,	,	PUNCT
biomedich-119	329	10	2014	2014	NUM
biomedich-119	329	11	.	.	PUNCT
biomedich-119	330	1	encapsulated	encapsulate	VERB
biomedich-119	330	2	islets	islet	NOUN
biomedich-119	330	3	for	for	ADP
biomedich-119	330	4	diabetes	diabetes	NOUN
biomedich-119	330	5	therapy	therapy	NOUN
biomedich-119	330	6	:	:	PUNCT
biomedich-119	330	7	history	history	NOUN
biomedich-119	330	8	,	,	PUNCT
biomedich-119	330	9	current	current	ADJ
biomedich-119	330	10	progress	progress	NOUN
biomedich-119	330	11	,	,	PUNCT
biomedich-119	330	12	and	and	CCONJ
biomedich-119	330	13	critical	critical	ADJ
biomedich-119	330	14	issues	issue	NOUN
biomedich-119	330	15	requiring	require	VERB
biomedich-119	330	16	solution	solution	NOUN
biomedich-119	330	17	.	.	PUNCT
biomedich-119	331	1	advanced	advanced	ADJ
biomedich-119	331	2	drug	drug	NOUN
biomedich-119	331	3	delivery	delivery	NOUN
biomedich-119	331	4	reviews	review	NOUN
biomedich-119	331	5	,	,	PUNCT
biomedich-119	331	6	67	67	NUM
biomedich-119	331	7	,	,	PUNCT
biomedich-119	331	8	pp.35	pp.35	NOUN
biomedich-119	331	9	-	-	PUNCT
biomedich-119	331	10	73	73	NUM
biomedich-119	331	11	.	.	PUNCT
biomedich-119	332	1	shapiro	shapiro	PROPN
biomedich-119	332	2	,	,	PUNCT
biomedich-119	332	3	a.j	a.j	PROPN
biomedich-119	332	4	.	.	PROPN
biomedich-119	332	5	,	,	PUNCT
biomedich-119	332	6	2012	2012	NUM
biomedich-119	332	7	.	.	PUNCT
biomedich-119	333	1	islet	islet	NOUN
biomedich-119	333	2	transplantation	transplantation	NOUN
biomedich-119	333	3	in	in	ADP
biomedich-119	333	4	type	type	NOUN
biomedich-119	333	5	1	1	NUM
biomedich-119	333	6	diabetes	diabetes	NOUN
biomedich-119	333	7	:	:	PUNCT
biomedich-119	333	8	ongoing	ongoing	ADJ
biomedich-119	333	9	challenges	challenge	NOUN
biomedich-119	333	10	,	,	PUNCT
biomedich-119	333	11	refined	refined	ADJ
biomedich-119	333	12	procedures	procedure	NOUN
biomedich-119	333	13	,	,	PUNCT
biomedich-119	333	14	and	and	CCONJ
biomedich-119	333	15	long	long	ADJ
biomedich-119	333	16	-	-	PUNCT
biomedich-119	333	17	term	term	NOUN
biomedich-119	333	18	outcome	outcome	NOUN
biomedich-119	333	19	.	.	PUNCT
biomedich-119	334	1	the	the	DET
biomedich-119	334	2	review	review	NOUN
biomedich-119	334	3	of	of	ADP
biomedich-119	334	4	diabetic	diabetic	ADJ
biomedich-119	334	5	studies	study	NOUN
biomedich-119	334	6	:	:	PUNCT
biomedich-119	334	7	rds	rd	NOUN
biomedich-119	334	8	,	,	PUNCT
biomedich-119	334	9	9(4	9(4	NOUN
biomedich-119	334	10	)	)	PUNCT
biomedich-119	334	11	,	,	PUNCT
biomedich-119	334	12	p.385	p.385	PROPN
biomedich-119	334	13	.	.	PUNCT
biomedich-119	335	1	shirley	shirley	PROPN
biomedich-119	335	2	,	,	PUNCT
biomedich-119	335	3	j.l	j.l	PROPN
biomedich-119	335	4	.	.	PROPN
biomedich-119	335	5	,	,	PUNCT
biomedich-119	335	6	de	de	PROPN
biomedich-119	335	7	jong	jong	PROPN
biomedich-119	335	8	,	,	PUNCT
biomedich-119	335	9	y.p	y.p	PROPN
biomedich-119	335	10	.	.	PROPN
biomedich-119	335	11	,	,	PUNCT
biomedich-119	335	12	terhorst	terhorst	NOUN
biomedich-119	335	13	,	,	PUNCT
biomedich-119	335	14	c.	c.	PROPN
biomedich-119	335	15	and	and	CCONJ
biomedich-119	335	16	herzog	herzog	PROPN
biomedich-119	335	17	,	,	PUNCT
biomedich-119	335	18	r.w	r.w	PROPN
biomedich-119	335	19	.	.	PROPN
biomedich-119	335	20	,	,	PUNCT
biomedich-119	335	21	2020	2020	NUM
biomedich-119	335	22	.	.	PUNCT
biomedich-119	336	1	immune	immune	ADJ
biomedich-119	336	2	responses	response	NOUN
biomedich-119	336	3	to	to	ADP
biomedich-119	336	4	viral	viral	ADJ
biomedich-119	336	5	gene	gene	NOUN
biomedich-119	336	6	therapy	therapy	NOUN
biomedich-119	336	7	vectors	vector	NOUN
biomedich-119	336	8	.	.	PUNCT
biomedich-119	337	1	molecular	molecular	ADJ
biomedich-119	337	2	therapy	therapy	NOUN
biomedich-119	337	3	,	,	PUNCT
biomedich-119	337	4	28(3	28(3	NUM
biomedich-119	337	5	)	)	PUNCT
biomedich-119	337	6	,	,	PUNCT
biomedich-119	337	7	pp.709	pp.709	NOUN
biomedich-119	337	8	-	-	PUNCT
biomedich-119	337	9	722	722	NUM
biomedich-119	337	10	.	.	PUNCT
biomedich-119	338	1	simeonovic	simeonovic	VERB
biomedich-119	338	2	,	,	PUNCT
biomedich-119	338	3	c.j	c.j	PROPN
biomedich-119	338	4	.	.	PROPN
biomedich-119	338	5	,	,	PUNCT
biomedich-119	338	6	popp	popp	PROPN
biomedich-119	338	7	,	,	PUNCT
biomedich-119	338	8	s.k	s.k	PROPN
biomedich-119	338	9	.	.	PROPN
biomedich-119	338	10	,	,	PUNCT
biomedich-119	338	11	brown	brown	PROPN
biomedich-119	338	12	,	,	PUNCT
biomedich-119	338	13	d.j	d.j	PROPN
biomedich-119	338	14	.	.	PROPN
biomedich-119	338	15	,	,	PUNCT
biomedich-119	338	16	li	li	PROPN
biomedich-119	338	17	,	,	PUNCT
biomedich-119	338	18	f.j	f.j	PROPN
biomedich-119	338	19	.	.	PROPN
biomedich-119	338	20	,	,	PUNCT
biomedich-119	338	21	lafferty	lafferty	PROPN
biomedich-119	338	22	,	,	PUNCT
biomedich-119	338	23	a.r	a.r	PROPN
biomedich-119	338	24	.	.	PROPN
biomedich-119	338	25	,	,	PUNCT
biomedich-119	338	26	freeman	freeman	PROPN
biomedich-119	338	27	,	,	PUNCT
biomedich-119	338	28	c.	c.	PROPN
biomedich-119	338	29	and	and	CCONJ
biomedich-119	338	30	parish	parish	PROPN
biomedich-119	338	31	,	,	PUNCT
biomedich-119	338	32	c.r	c.r	PROPN
biomedich-119	338	33	.	.	PROPN
biomedich-119	338	34	,	,	PUNCT
biomedich-119	338	35	2020	2020	NUM
biomedich-119	338	36	.	.	PUNCT
biomedich-119	339	1	heparanase	heparanase	NOUN
biomedich-119	339	2	and	and	CCONJ
biomedich-119	339	3	type	type	VERB
biomedich-119	339	4	1	1	NUM
biomedich-119	339	5	diabetes	diabetes	NOUN
biomedich-119	339	6	.	.	PUNCT
biomedich-119	340	1	in	in	ADP
biomedich-119	340	2	heparanase	heparanase	NOUN
biomedich-119	340	3	(	(	PUNCT
biomedich-119	340	4	pp	pp	ADJ
biomedich-119	340	5	.	.	PUNCT
biomedich-119	340	6	607	607	NUM
biomedich-119	340	7	-	-	SYM
biomedich-119	340	8	630	630	NUM
biomedich-119	340	9	)	)	PUNCT
biomedich-119	340	10	.	.	PUNCT
biomedich-119	341	1	springer	springer	NOUN
biomedich-119	341	2	,	,	PUNCT
biomedich-119	341	3	cham	cham	PROPN
biomedich-119	341	4	.	.	PUNCT
biomedich-119	342	1	sluch	sluch	ADJ
biomedich-119	342	2	,	,	PUNCT
biomedich-119	342	3	v.	v.	PROPN
biomedich-119	342	4	,	,	PUNCT
biomedich-119	342	5	swain	swain	PROPN
biomedich-119	342	6	,	,	PUNCT
biomedich-119	342	7	d.	d.	PROPN
biomedich-119	342	8	,	,	PUNCT
biomedich-119	342	9	whipple	whipple	PROPN
biomedich-119	342	10	,	,	PUNCT
biomedich-119	342	11	w.	w.	PROPN
biomedich-119	342	12	,	,	PUNCT
biomedich-119	342	13	liao	liao	PROPN
biomedich-119	342	14	,	,	PUNCT
biomedich-119	342	15	m.	m.	NOUN
biomedich-119	342	16	,	,	PUNCT
biomedich-119	342	17	bhoumik	bhoumik	ADJ
biomedich-119	342	18	,	,	PUNCT
biomedich-119	342	19	a.	a.	NOUN
biomedich-119	342	20	,	,	PUNCT
biomedich-119	342	21	agulnick	agulnick	PROPN
biomedich-119	342	22	,	,	PUNCT
biomedich-119	342	23	a.d	a.d	PROPN
biomedich-119	342	24	.	.	PROPN
biomedich-119	342	25	and	and	CCONJ
biomedich-119	342	26	rezania	rezania	PROPN
biomedich-119	342	27	,	,	PUNCT
biomedich-119	342	28	a.	a.	NOUN
biomedich-119	342	29	,	,	PUNCT
biomedich-119	342	30	2019	2019	NUM
biomedich-119	342	31	,	,	PUNCT
biomedich-119	342	32	september	september	PROPN
biomedich-119	342	33	.	.	PUNCT
biomedich-119	343	1	crisprediting	crispredite	VERB
biomedich-119	343	2	of	of	ADP
biomedich-119	343	3	hescs	hesc	NOUN
biomedich-119	343	4	allows	allow	VERB
biomedich-119	343	5	for	for	ADP
biomedich-119	343	6	production	production	NOUN
biomedich-119	343	7	of	of	ADP
biomedich-119	343	8	immune	immune	ADJ
biomedich-119	343	9	evasive	evasive	ADJ
biomedich-119	343	10	cells	cell	NOUN
biomedich-119	343	11	capable	capable	ADJ
biomedich-119	343	12	of	of	ADP
biomedich-119	343	13	differentiation	differentiation	NOUN
biomedich-119	343	14	to	to	ADP
biomedich-119	343	15	pancreatic	pancreatic	ADJ
biomedich-119	343	16	progenitors	progenitor	NOUN
biomedich-119	343	17	for	for	ADP
biomedich-119	343	18	future	future	ADJ
biomedich-119	343	19	type	type	NOUN
biomedich-119	343	20	1	1	NUM
biomedich-119	343	21	diabetes	diabetes	NOUN
biomedich-119	343	22	therapy	therapy	NOUN
biomedich-119	343	23	.	.	PUNCT
biomedich-119	344	1	in	in	ADP
biomedich-119	344	2	diabetologia	diabetologia	NOUN
biomedich-119	344	3	(	(	PUNCT
biomedich-119	344	4	vol	vol	NOUN
biomedich-119	344	5	.	.	PROPN
biomedich-119	345	1	62	62	NUM
biomedich-119	345	2	,	,	PUNCT
biomedich-119	345	3	pp	pp	PROPN
biomedich-119	345	4	.	.	PUNCT
biomedich-119	346	1	s6	s6	PROPN
biomedich-119	346	2	-	-	PUNCT
biomedich-119	346	3	s7	s7	NOUN
biomedich-119	346	4	)	)	PUNCT
biomedich-119	346	5	.	.	PUNCT
biomedich-119	347	1	233	233	NUM
biomedich-119	347	2	spring	spring	NOUN
biomedich-119	347	3	st	st	PROPN
biomedich-119	347	4	,	,	PUNCT
biomedich-119	347	5	new	new	PROPN
biomedich-119	347	6	york	york	PROPN
biomedich-119	347	7	,	,	PUNCT
biomedich-119	347	8	ny	ny	PROPN
biomedich-119	347	9	10013	10013	NUM
biomedich-119	347	10	usa	usa	PROPN
biomedich-119	347	11	:	:	PUNCT
biomedich-119	347	12	springer	springer	NOUN
biomedich-119	347	13	.	.	PUNCT
biomedich-119	347	14	smail	smail	PROPN
biomedich-119	347	15	,	,	PUNCT
biomedich-119	347	16	h.	h.	PROPN
biomedich-119	347	17	,	,	PUNCT
biomedich-119	347	18	kareem	kareem	PROPN
biomedich-119	347	19	,	,	PUNCT
biomedich-119	347	20	s.	s.	PROPN
biomedich-119	347	21	and	and	CCONJ
biomedich-119	347	22	abdulkareem	abdulkareem	PROPN
biomedich-119	347	23	,	,	PUNCT
biomedich-119	347	24	n.	n.	NOUN
biomedich-119	347	25	(	(	PUNCT
biomedich-119	347	26	2019	2019	NUM
biomedich-119	347	27	)	)	PUNCT
biomedich-119	347	28	“	"	PUNCT
biomedich-119	347	29	comparative	comparative	ADJ
biomedich-119	347	30	study	study	NOUN
biomedich-119	347	31	of	of	ADP
biomedich-119	347	32	the	the	DET
biomedich-119	347	33	fingerprint	fingerprint	NOUN
biomedich-119	347	34	pattern	pattern	NOUN
biomedich-119	347	35	among	among	ADP
biomedich-119	347	36	diabetic	diabetic	ADJ
biomedich-119	347	37	(	(	PUNCT
biomedich-119	347	38	type	type	NOUN
biomedich-119	347	39	1	1	NUM
biomedich-119	347	40	)	)	PUNCT
biomedich-119	347	41	&	&	CCONJ
biomedich-119	347	42	non	non	ADJ
biomedich-119	347	43	-	-	ADJ
biomedich-119	347	44	diabetic	diabetic	ADJ
biomedich-119	347	45	children	child	NOUN
biomedich-119	347	46	in	in	ADP
biomedich-119	347	47	koya	koya	PROPN
biomedich-119	347	48	city	city	PROPN
biomedich-119	347	49	”	"	PUNCT
biomedich-119	347	50	,	,	PUNCT
biomedich-119	347	51	journal	journal	NOUN
biomedich-119	347	52	of	of	ADP
biomedich-119	347	53	advanced	advanced	ADJ
biomedich-119	347	54	laboratory	laboratory	NOUN
biomedich-119	347	55	research	research	NOUN
biomedich-119	347	56	in	in	ADP
biomedich-119	347	57	biology	biology	NOUN
biomedich-119	347	58	,	,	PUNCT
biomedich-119	347	59	10(2	10(2	NUM
biomedich-119	347	60	)	)	PUNCT
biomedich-119	347	61	,	,	PUNCT
biomedich-119	347	62	pp	pp	PROPN
biomedich-119	347	63	.	.	PUNCT
biomedich-119	348	1	41	41	NUM
biomedich-119	348	2	-	-	SYM
biomedich-119	348	3	47	47	NUM
biomedich-119	348	4	.	.	PUNCT
biomedich-119	349	1	takei	takei	PROPN
biomedich-119	349	2	,	,	PUNCT
biomedich-119	349	3	i.	i.	PROPN
biomedich-119	349	4	and	and	CCONJ
biomedich-119	349	5	kasatani	kasatani	PROPN
biomedich-119	349	6	,	,	PUNCT
biomedich-119	349	7	t.	t.	PROPN
biomedich-119	349	8	,	,	PUNCT
biomedich-119	349	9	2004	2004	NUM
biomedich-119	349	10	.	.	PUNCT
biomedich-119	350	1	future	future	ADJ
biomedich-119	350	2	therapy	therapy	NOUN
biomedich-119	350	3	of	of	ADP
biomedich-119	350	4	diabetes	diabetes	NOUN
biomedich-119	350	5	mellitus	mellitus	NOUN
biomedich-119	350	6	.	.	PUNCT
biomedich-119	351	1	biomedicine	biomedicine	PROPN
biomedich-119	351	2	&	&	CCONJ
biomedich-119	351	3	pharmacotherapy	pharmacotherapy	NOUN
biomedich-119	351	4	,	,	PUNCT
biomedich-119	351	5	58(10	58(10	NUM
biomedich-119	351	6	)	)	PUNCT
biomedich-119	351	7	,	,	PUNCT
biomedich-119	351	8	pp.578581	pp.578581	PROPN
biomedich-119	351	9	.	.	PROPN
biomedich-119	351	10	teta	teta	PROPN
biomedich-119	351	11	,	,	PUNCT
biomedich-119	351	12	m.	m.	NOUN
biomedich-119	351	13	,	,	PUNCT
biomedich-119	351	14	rankin	rankin	PROPN
biomedich-119	351	15	,	,	PUNCT
biomedich-119	351	16	m.m	m.m	PROPN
biomedich-119	351	17	.	.	PROPN
biomedich-119	351	18	,	,	PUNCT
biomedich-119	351	19	long	long	ADV
biomedich-119	351	20	,	,	PUNCT
biomedich-119	351	21	s.y	s.y	PROPN
biomedich-119	351	22	.	.	PROPN
biomedich-119	351	23	,	,	PUNCT
biomedich-119	351	24	stein	stein	PROPN
biomedich-119	351	25	,	,	PUNCT
biomedich-119	351	26	g.m	g.m	PROPN
biomedich-119	351	27	.	.	PROPN
biomedich-119	351	28	and	and	CCONJ
biomedich-119	351	29	kushner	kushner	PROPN
biomedich-119	351	30	,	,	PUNCT
biomedich-119	351	31	j.a	j.a	PROPN
biomedich-119	351	32	.	.	PROPN
biomedich-119	351	33	,	,	PUNCT
biomedich-119	351	34	2007	2007	NUM
biomedich-119	351	35	.	.	PUNCT
biomedich-119	352	1	growth	growth	NOUN
biomedich-119	352	2	and	and	CCONJ
biomedich-119	352	3	regeneration	regeneration	NOUN
biomedich-119	352	4	of	of	ADP
biomedich-119	352	5	adult	adult	NOUN
biomedich-119	352	6	β	β	NOUN
biomedich-119	352	7	cells	cell	NOUN
biomedich-119	352	8	does	do	AUX
biomedich-119	352	9	not	not	PART
biomedich-119	352	10	involve	involve	VERB
biomedich-119	352	11	specialized	specialized	ADJ
biomedich-119	352	12	progenitors	progenitor	NOUN
biomedich-119	352	13	.	.	PUNCT
biomedich-119	353	1	developmental	developmental	ADJ
biomedich-119	353	2	cell	cell	NOUN
biomedich-119	353	3	,	,	PUNCT
biomedich-119	353	4	12(5	12(5	NUM
biomedich-119	353	5	)	)	PUNCT
biomedich-119	353	6	,	,	PUNCT
biomedich-119	353	7	pp.817	pp.817	PROPN
biomedich-119	353	8	-	-	PUNCT
biomedich-119	353	9	826	826	NUM
biomedich-119	353	10	.	.	PUNCT
biomedich-119	354	1	thorel	thorel	PROPN
biomedich-119	354	2	,	,	PUNCT
biomedich-119	354	3	f.	f.	PROPN
biomedich-119	354	4	,	,	PUNCT
biomedich-119	354	5	népote	népote	NOUN
biomedich-119	354	6	,	,	PUNCT
biomedich-119	354	7	v.	v.	PROPN
biomedich-119	354	8	,	,	PUNCT
biomedich-119	354	9	avril	avril	PROPN
biomedich-119	354	10	,	,	PUNCT
biomedich-119	354	11	i.	i.	PROPN
biomedich-119	354	12	,	,	PUNCT
biomedich-119	354	13	kohno	kohno	PROPN
biomedich-119	354	14	,	,	PUNCT
biomedich-119	354	15	k.	k.	PROPN
biomedich-119	354	16	,	,	PUNCT
biomedich-119	354	17	desgraz	desgraz	PROPN
biomedich-119	354	18	,	,	PUNCT
biomedich-119	354	19	r.	r.	PROPN
biomedich-119	354	20	,	,	PUNCT
biomedich-119	354	21	chera	chera	PROPN
biomedich-119	354	22	,	,	PUNCT
biomedich-119	354	23	s.	s.	PROPN
biomedich-119	354	24	and	and	CCONJ
biomedich-119	354	25	herrera	herrera	PROPN
biomedich-119	354	26	,	,	PUNCT
biomedich-119	354	27	p.l	p.l	PROPN
biomedich-119	354	28	.	.	PROPN
biomedich-119	354	29	,	,	PUNCT
biomedich-119	354	30	2010	2010	NUM
biomedich-119	354	31	.	.	PUNCT
biomedich-119	355	1	conversion	conversion	NOUN
biomedich-119	355	2	of	of	ADP
biomedich-119	355	3	adult	adult	NOUN
biomedich-119	355	4	pancreatic	pancreatic	ADJ
biomedich-119	355	5	αcells	αcell	NOUN
biomedich-119	355	6	to	to	ADP
biomedich-119	355	7	β	β	NOUN
biomedich-119	355	8	-	-	NOUN
biomedich-119	355	9	cells	cell	NOUN
biomedich-119	355	10	after	after	ADP
biomedich-119	355	11	extreme	extreme	ADJ
biomedich-119	355	12	β	β	NOUN
biomedich-119	355	13	-	-	NOUN
biomedich-119	355	14	cell	cell	NOUN
biomedich-119	355	15	loss	loss	NOUN
biomedich-119	355	16	.	.	PUNCT
biomedich-119	356	1	nature	nature	NOUN
biomedich-119	356	2	,	,	PUNCT
biomedich-119	356	3	464(7292	464(7292	NUM
biomedich-119	356	4	)	)	PUNCT
biomedich-119	356	5	,	,	PUNCT
biomedich-119	356	6	pp.1149	pp.1149	NOUN
biomedich-119	356	7	-	-	PUNCT
biomedich-119	356	8	1154	1154	NUM
biomedich-119	356	9	.	.	PUNCT
biomedich-119	357	1	thyssen	thyssen	PROPN
biomedich-119	357	2	,	,	PUNCT
biomedich-119	357	3	s.	s.	PROPN
biomedich-119	357	4	,	,	PUNCT
biomedich-119	357	5	arany	arany	NOUN
biomedich-119	357	6	,	,	PUNCT
biomedich-119	357	7	e.	e.	PROPN
biomedich-119	357	8	and	and	CCONJ
biomedich-119	357	9	hill	hill	PROPN
biomedich-119	357	10	,	,	PUNCT
biomedich-119	357	11	d.j	d.j	PROPN
biomedich-119	357	12	.	.	PROPN
biomedich-119	357	13	,	,	PUNCT
biomedich-119	357	14	2006	2006	NUM
biomedich-119	357	15	.	.	PUNCT
biomedich-119	358	1	ontogeny	ontogeny	NOUN
biomedich-119	358	2	of	of	ADP
biomedich-119	358	3	regeneration	regeneration	NOUN
biomedich-119	358	4	of	of	ADP
biomedich-119	358	5	β	β	NOUN
biomedich-119	358	6	-	-	NOUN
biomedich-119	358	7	cells	cell	NOUN
biomedich-119	358	8	in	in	ADP
biomedich-119	358	9	the	the	DET
biomedich-119	358	10	neonatal	neonatal	ADJ
biomedich-119	358	11	rat	rat	NOUN
biomedich-119	358	12	after	after	ADP
biomedich-119	358	13	treatment	treatment	NOUN
biomedich-119	358	14	with	with	ADP
biomedich-119	358	15	streptozotocin	streptozotocin	PROPN
biomedich-119	358	16	.	.	PUNCT
biomedich-119	359	1	endocrinology	endocrinology	NOUN
biomedich-119	359	2	,	,	PUNCT
biomedich-119	359	3	147(5	147(5	NUM
biomedich-119	359	4	)	)	PUNCT
biomedich-119	359	5	,	,	PUNCT
biomedich-119	359	6	pp.2346	pp.2346	PROPN
biomedich-119	359	7	-	-	PUNCT
biomedich-119	359	8	2356	2356	NUM
biomedich-119	359	9	.	.	PUNCT
biomedich-119	360	1	tian	tian	ADJ
biomedich-119	360	2	,	,	PUNCT
biomedich-119	360	3	c.	c.	PROPN
biomedich-119	360	4	,	,	PUNCT
biomedich-119	360	5	ansari	ansari	ADJ
biomedich-119	360	6	,	,	PUNCT
biomedich-119	360	7	m.j.i	m.j.i	NOUN
biomedich-119	360	8	.	.	PROPN
biomedich-119	360	9	,	,	PUNCT
biomedich-119	360	10	paez	paez	PROPN
biomedich-119	360	11	-	-	PUNCT
biomedich-119	360	12	cortez	cortez	PROPN
biomedich-119	360	13	,	,	PUNCT
biomedich-119	360	14	j.	j.	PROPN
biomedich-119	360	15	,	,	PUNCT
biomedich-119	360	16	bagley	bagley	PROPN
biomedich-119	360	17	,	,	PUNCT
biomedich-119	360	18	j.	j.	PROPN
biomedich-119	360	19	,	,	PUNCT
biomedich-119	360	20	godwin	godwin	PROPN
biomedich-119	360	21	,	,	PUNCT
biomedich-119	360	22	j.	j.	PROPN
biomedich-119	360	23	,	,	PUNCT
biomedich-119	360	24	donnarumma	donnarumma	PROPN
biomedich-119	360	25	,	,	PUNCT
biomedich-119	360	26	m.	m.	NOUN
biomedich-119	360	27	,	,	PUNCT
biomedich-119	360	28	sayegh	sayegh	PROPN
biomedich-119	360	29	,	,	PUNCT
biomedich-119	360	30	m.h	m.h	PROPN
biomedich-119	360	31	.	.	PROPN
biomedich-119	360	32	and	and	CCONJ
biomedich-119	360	33	iacomini	iacomini	PROPN
biomedich-119	360	34	,	,	PUNCT
biomedich-119	360	35	j.	j.	PROPN
biomedich-119	360	36	,	,	PUNCT
biomedich-119	360	37	2007	2007	NUM
biomedich-119	360	38	.	.	PUNCT
biomedich-119	361	1	induction	induction	NOUN
biomedich-119	361	2	of	of	ADP
biomedich-119	361	3	robust	robust	ADJ
biomedich-119	361	4	diabetes	diabetes	NOUN
biomedich-119	361	5	resistance	resistance	NOUN
biomedich-119	361	6	and	and	CCONJ
biomedich-119	361	7	prevention	prevention	NOUN
biomedich-119	361	8	of	of	ADP
biomedich-119	361	9	recurrent	recurrent	ADJ
biomedich-119	361	10	type	type	NOUN
biomedich-119	361	11	1	1	NUM
biomedich-119	361	12	diabetes	diabetes	NOUN
biomedich-119	361	13	following	follow	VERB
biomedich-119	361	14	islet	islet	NOUN
biomedich-119	361	15	transplantation	transplantation	NOUN
biomedich-119	361	16	by	by	ADP
biomedich-119	361	17	gene	gene	NOUN
biomedich-119	361	18	therapy	therapy	NOUN
biomedich-119	361	19	.	.	PUNCT
biomedich-119	362	1	the	the	DET
biomedich-119	362	2	journal	journal	NOUN
biomedich-119	362	3	of	of	ADP
biomedich-119	362	4	immunology	immunology	NOUN
biomedich-119	362	5	,	,	PUNCT
biomedich-119	362	6	179(10	179(10	NUM
biomedich-119	362	7	)	)	PUNCT
biomedich-119	362	8	,	,	PUNCT
biomedich-119	362	9	pp.67626769	pp.67626769	PROPN
biomedich-119	362	10	.	.	PROPN
biomedich-119	363	1	van	van	PROPN
biomedich-119	363	2	belle	belle	PROPN
biomedich-119	363	3	,	,	PUNCT
biomedich-119	363	4	t.l	t.l	PROPN
biomedich-119	363	5	.	.	PROPN
biomedich-119	363	6	,	,	PUNCT
biomedich-119	363	7	coppieters	coppieter	NOUN
biomedich-119	363	8	,	,	PUNCT
biomedich-119	363	9	k.t	k.t	PROPN
biomedich-119	363	10	.	.	PROPN
biomedich-119	363	11	and	and	CCONJ
biomedich-119	363	12	von	von	PROPN
biomedich-119	363	13	herrath	herrath	PROPN
biomedich-119	363	14	,	,	PUNCT
biomedich-119	363	15	m.g	m.g	PROPN
biomedich-119	363	16	.	.	PROPN
biomedich-119	363	17	,	,	PUNCT
biomedich-119	363	18	2011	2011	NUM
biomedich-119	363	19	.	.	PUNCT
biomedich-119	364	1	type	type	NOUN
biomedich-119	364	2	1	1	NUM
biomedich-119	364	3	diabetes	diabetes	NOUN
biomedich-119	364	4	:	:	PUNCT
biomedich-119	364	5	etiology	etiology	NOUN
biomedich-119	364	6	,	,	PUNCT
biomedich-119	364	7	immunology	immunology	NOUN
biomedich-119	364	8	,	,	PUNCT
biomedich-119	364	9	and	and	CCONJ
biomedich-119	364	10	therapeutic	therapeutic	ADJ
biomedich-119	364	11	strategies	strategy	NOUN
biomedich-119	364	12	.	.	PUNCT
biomedich-119	365	1	physiological	physiological	ADJ
biomedich-119	365	2	reviews	review	NOUN
biomedich-119	365	3	,	,	PUNCT
biomedich-119	365	4	91(1	91(1	NUM
biomedich-119	365	5	)	)	PUNCT
biomedich-119	365	6	,	,	PUNCT
biomedich-119	365	7	pp.79	pp.79	NOUN
biomedich-119	365	8	-	-	SYM
biomedich-119	365	9	118	118	NUM
biomedich-119	365	10	.	.	PUNCT
biomedich-119	366	1	verma	verma	PROPN
biomedich-119	366	2	,	,	PUNCT
biomedich-119	366	3	i.m	i.m	PROPN
biomedich-119	366	4	.	.	PROPN
biomedich-119	366	5	,	,	PUNCT
biomedich-119	366	6	naldini	naldini	PROPN
biomedich-119	366	7	,	,	PUNCT
biomedich-119	366	8	l.	l.	PROPN
biomedich-119	366	9	,	,	PUNCT
biomedich-119	366	10	kafri	kafri	PROPN
biomedich-119	366	11	,	,	PUNCT
biomedich-119	366	12	t.	t.	PROPN
biomedich-119	366	13	,	,	PUNCT
biomedich-119	366	14	miyoshi	miyoshi	PROPN
biomedich-119	366	15	,	,	PUNCT
biomedich-119	366	16	h.	h.	PROPN
biomedich-119	366	17	,	,	PUNCT
biomedich-119	366	18	takahashi	takahashi	PROPN
biomedich-119	366	19	,	,	PUNCT
biomedich-119	366	20	m.	m.	NOUN
biomedich-119	366	21	,	,	PUNCT
biomedich-119	366	22	blömer	blömer	PROPN
biomedich-119	366	23	,	,	PUNCT
biomedich-119	366	24	u.	u.	PROPN
biomedich-119	366	25	,	,	PUNCT
biomedich-119	366	26	somia	somia	NOUN
biomedich-119	366	27	,	,	PUNCT
biomedich-119	366	28	n.	n.	PROPN
biomedich-119	366	29	,	,	PUNCT
biomedich-119	366	30	wang	wang	PROPN
biomedich-119	366	31	,	,	PUNCT
biomedich-119	366	32	l.	l.	PROPN
biomedich-119	366	33	and	and	CCONJ
biomedich-119	366	34	gage	gage	PROPN
biomedich-119	366	35	,	,	PUNCT
biomedich-119	366	36	f.h	f.h	PROPN
biomedich-119	366	37	.	.	PROPN
biomedich-119	366	38	,	,	PUNCT
biomedich-119	366	39	2000	2000	NUM
biomedich-119	366	40	.	.	PUNCT
biomedich-119	367	1	gene	gene	NOUN
biomedich-119	367	2	therapy	therapy	NOUN
biomedich-119	367	3	:	:	PUNCT
biomedich-119	367	4	promises	promise	NOUN
biomedich-119	367	5	,	,	PUNCT
biomedich-119	367	6	problems	problem	NOUN
biomedich-119	367	7	and	and	CCONJ
biomedich-119	367	8	prospects	prospect	NOUN
biomedich-119	367	9	.	.	PUNCT
biomedich-119	368	1	in	in	ADP
biomedich-119	368	2	genes	gene	NOUN
biomedich-119	368	3	and	and	CCONJ
biomedich-119	368	4	resistance	resistance	NOUN
biomedich-119	368	5	to	to	ADP
biomedich-119	368	6	disease	disease	NOUN
biomedich-119	368	7	(	(	PUNCT
biomedich-119	368	8	pp	pp	ADJ
biomedich-119	368	9	.	.	PUNCT
biomedich-119	368	10	147	147	NUM
biomedich-119	368	11	-	-	SYM
biomedich-119	368	12	157	157	NUM
biomedich-119	368	13	)	)	PUNCT
biomedich-119	368	14	.	.	PUNCT
biomedich-119	369	1	springer	springer	NOUN
biomedich-119	369	2	,	,	PUNCT
biomedich-119	369	3	berlin	berlin	PROPN
biomedich-119	369	4	,	,	PUNCT
biomedich-119	369	5	heidelberg	heidelberg	PROPN
biomedich-119	369	6	.	.	PUNCT
biomedich-119	370	1	wainwright	wainwright	PROPN
biomedich-119	370	2	,	,	PUNCT
biomedich-119	370	3	s.p	s.p	PROPN
biomedich-119	370	4	.	.	PROPN
biomedich-119	370	5	,	,	PUNCT
biomedich-119	370	6	williams	williams	PROPN
biomedich-119	370	7	,	,	PUNCT
biomedich-119	370	8	c.	c.	PROPN
biomedich-119	370	9	,	,	PUNCT
biomedich-119	370	10	michael	michael	PROPN
biomedich-119	370	11	,	,	PUNCT
biomedich-119	370	12	m.	m.	NOUN
biomedich-119	370	13	,	,	PUNCT
biomedich-119	370	14	farsides	farside	NOUN
biomedich-119	370	15	,	,	PUNCT
biomedich-119	370	16	b.	b.	PROPN
biomedich-119	370	17	and	and	CCONJ
biomedich-119	370	18	cribb	cribb	PROPN
biomedich-119	370	19	,	,	PUNCT
biomedich-119	370	20	a.	a.	PROPN
biomedich-119	370	21	,	,	PUNCT
biomedich-119	370	22	2006	2006	NUM
biomedich-119	370	23	.	.	PUNCT
biomedich-119	371	1	from	from	ADP
biomedich-119	371	2	bench	bench	NOUN
biomedich-119	371	3	to	to	ADP
biomedich-119	371	4	bedside	bedside	NOUN
biomedich-119	371	5	?	?	PUNCT
biomedich-119	371	6	biomedical	biomedical	ADJ
biomedich-119	371	7	scientists	scientist	NOUN
biomedich-119	371	8	’	'	PUNCT
biomedich-119	371	9	expectations	expectation	NOUN
biomedich-119	371	10	of	of	ADP
biomedich-119	371	11	stem	stem	NOUN
biomedich-119	371	12	cell	cell	NOUN
biomedich-119	371	13	science	science	NOUN
biomedich-119	371	14	as	as	ADP
biomedich-119	371	15	a	a	DET
biomedich-119	371	16	future	future	ADJ
biomedich-119	371	17	therapy	therapy	NOUN
biomedich-119	371	18	for	for	ADP
biomedich-119	371	19	diabetes	diabetes	NOUN
biomedich-119	371	20	.	.	PUNCT
biomedich-119	372	1	social	social	ADJ
biomedich-119	372	2	science	science	PROPN
biomedich-119	372	3	&	&	CCONJ
biomedich-119	372	4	medicine	medicine	NOUN
biomedich-119	372	5	,	,	PUNCT
biomedich-119	372	6	63(8	63(8	NUM
biomedich-119	372	7	)	)	PUNCT
biomedich-119	372	8	,	,	PUNCT
biomedich-119	372	9	pp.2052	pp.2052	PROPN
biomedich-119	372	10	-	-	PUNCT
biomedich-119	372	11	2064	2064	NUM
biomedich-119	372	12	.	.	PUNCT
biomedich-119	373	1	wang	wang	PROPN
biomedich-119	373	2	,	,	PUNCT
biomedich-119	373	3	h.	h.	PROPN
biomedich-119	373	4	,	,	PUNCT
biomedich-119	373	5	wei	wei	PROPN
biomedich-119	373	6	,	,	PUNCT
biomedich-119	373	7	x.	x.	PROPN
biomedich-119	373	8	,	,	PUNCT
biomedich-119	373	9	shi	shi	PROPN
biomedich-119	373	10	,	,	PUNCT
biomedich-119	373	11	w.	w.	PROPN
biomedich-119	373	12	,	,	PUNCT
biomedich-119	373	13	he	he	PRON
biomedich-119	373	14	,	,	PUNCT
biomedich-119	373	15	j.	j.	PROPN
biomedich-119	373	16	and	and	CCONJ
biomedich-119	373	17	luo	luo	PROPN
biomedich-119	373	18	,	,	PUNCT
biomedich-119	373	19	l.	l.	PROPN
biomedich-119	373	20	,	,	PUNCT
biomedich-119	373	21	2020	2020	NUM
biomedich-119	373	22	.	.	PUNCT
biomedich-119	374	1	key	key	ADJ
biomedich-119	374	2	developmental	developmental	ADJ
biomedich-119	374	3	regulators	regulator	NOUN
biomedich-119	374	4	suggest	suggest	VERB
biomedich-119	374	5	multiple	multiple	ADJ
biomedich-119	374	6	origins	origin	NOUN
biomedich-119	374	7	of	of	ADP
biomedich-119	374	8	pancreatic	pancreatic	ADJ
biomedich-119	374	9	beta	beta	NOUN
biomedich-119	374	10	cell	cell	NOUN
biomedich-119	374	11	regeneration	regeneration	NOUN
biomedich-119	374	12	.	.	PUNCT
biomedich-119	375	1	zebrafish	zebrafish	ADJ
biomedich-119	375	2	.	.	PUNCT
biomedich-119	376	1	wang	wang	PROPN
biomedich-119	376	2	,	,	PUNCT
biomedich-119	376	3	j.h	j.h	PROPN
biomedich-119	376	4	.	.	PROPN
biomedich-119	376	5	,	,	PUNCT
biomedich-119	376	6	roberts	roberts	PROPN
biomedich-119	376	7	,	,	PUNCT
biomedich-119	376	8	g.e	g.e	PROPN
biomedich-119	376	9	.	.	PROPN
biomedich-119	376	10	and	and	CCONJ
biomedich-119	376	11	liu	liu	PROPN
biomedich-119	376	12	,	,	PUNCT
biomedich-119	376	13	g.s	g.s	PROPN
biomedich-119	376	14	.	.	PROPN
biomedich-119	376	15	,	,	PUNCT
biomedich-119	376	16	2020	2020	NUM
biomedich-119	376	17	.	.	PUNCT
biomedich-119	377	1	updates	update	NOUN
biomedich-119	377	2	on	on	ADP
biomedich-119	377	3	gene	gene	NOUN
biomedich-119	377	4	therapy	therapy	NOUN
biomedich-119	377	5	for	for	ADP
biomedich-119	377	6	diabetic	diabetic	ADJ
biomedich-119	377	7	retinopathy	retinopathy	NOUN
biomedich-119	377	8	.	.	PUNCT
biomedich-119	378	1	current	current	ADJ
biomedich-119	378	2	diabetes	diabetes	NOUN
biomedich-119	378	3	reports	report	NOUN
biomedich-119	378	4	,	,	PUNCT
biomedich-119	378	5	20	20	NUM
biomedich-119	378	6	,	,	PUNCT
biomedich-119	378	7	pp.1	pp.1	NOUN
biomedich-119	378	8	-	-	PUNCT
biomedich-119	378	9	12	12	NUM
biomedich-119	378	10	.	.	PUNCT
biomedich-119	379	1	wang	wang	PROPN
biomedich-119	379	2	,	,	PUNCT
biomedich-119	379	3	m.y	m.y	PROPN
biomedich-119	379	4	.	.	PROPN
biomedich-119	379	5	,	,	PUNCT
biomedich-119	379	6	chen	chen	PROPN
biomedich-119	379	7	,	,	PUNCT
biomedich-119	379	8	l.	l.	PROPN
biomedich-119	379	9	,	,	PUNCT
biomedich-119	379	10	clark	clark	PROPN
biomedich-119	379	11	,	,	PUNCT
biomedich-119	379	12	g.o	g.o	PROPN
biomedich-119	379	13	.	.	PROPN
biomedich-119	379	14	,	,	PUNCT
biomedich-119	379	15	lee	lee	PROPN
biomedich-119	379	16	,	,	PUNCT
biomedich-119	379	17	y.	y.	PROPN
biomedich-119	379	18	,	,	PUNCT
biomedich-119	379	19	stevens	stevens	PROPN
biomedich-119	379	20	,	,	PUNCT
biomedich-119	379	21	r.d	r.d	PROPN
biomedich-119	379	22	.	.	PROPN
biomedich-119	379	23	,	,	PUNCT
biomedich-119	379	24	ilkayeva	ilkayeva	PROPN
biomedich-119	379	25	,	,	PUNCT
biomedich-119	379	26	o.r	o.r	PROPN
biomedich-119	379	27	.	.	PROPN
biomedich-119	379	28	,	,	PUNCT
biomedich-119	379	29	wenner	wenner	PROPN
biomedich-119	379	30	,	,	PUNCT
biomedich-119	379	31	b.r	b.r	PROPN
biomedich-119	379	32	.	.	PROPN
biomedich-119	379	33	,	,	PUNCT
biomedich-119	379	34	bain	bain	PROPN
biomedich-119	379	35	,	,	PUNCT
biomedich-119	379	36	j.r	j.r	PROPN
biomedich-119	379	37	.	.	PROPN
biomedich-119	379	38	,	,	PUNCT
biomedich-119	379	39	charron	charron	PROPN
biomedich-119	379	40	,	,	PUNCT
biomedich-119	379	41	m.j	m.j	PROPN
biomedich-119	379	42	.	.	PROPN
biomedich-119	379	43	,	,	PUNCT
biomedich-119	379	44	newgard	newgard	PROPN
biomedich-119	379	45	,	,	PUNCT
biomedich-119	379	46	c.b	c.b	PROPN
biomedich-119	379	47	.	.	PROPN
biomedich-119	379	48	and	and	CCONJ
biomedich-119	379	49	unger	unger	PROPN
biomedich-119	379	50	,	,	PUNCT
biomedich-119	379	51	r.h	r.h	PROPN
biomedich-119	379	52	.	.	PROPN
biomedich-119	379	53	,	,	PUNCT
biomedich-119	379	54	2010	2010	NUM
biomedich-119	379	55	.	.	PUNCT
biomedich-119	380	1	leptin	leptin	NOUN
biomedich-119	380	2	therapy	therapy	NOUN
biomedich-119	380	3	in	in	ADP
biomedich-119	380	4	insulin	insulin	NOUN
biomedich-119	380	5	-	-	PUNCT
biomedich-119	380	6	deficient	deficient	ADJ
biomedich-119	380	7	type	type	NOUN
biomedich-119	380	8	i	i	PRON
biomedich-119	380	9	diabetes	diabete	VERB
biomedich-119	380	10	.	.	PUNCT
biomedich-119	381	1	proceedings	proceeding	NOUN
biomedich-119	381	2	of	of	ADP
biomedich-119	381	3	the	the	DET
biomedich-119	381	4	national	national	PROPN
biomedich-119	381	5	academy	academy	PROPN
biomedich-119	381	6	of	of	ADP
biomedich-119	381	7	sciences	sciences	PROPN
biomedich-119	381	8	,	,	PUNCT
biomedich-119	381	9	107(11	107(11	NUM
biomedich-119	381	10	)	)	PUNCT
biomedich-119	381	11	,	,	PUNCT
biomedich-119	381	12	pp.4813	pp.4813	NOUN
biomedich-119	381	13	-	-	PUNCT
biomedich-119	381	14	4819	4819	NUM
biomedich-119	381	15	.	.	PUNCT
biomedich-119	382	1	wirth	wirth	PROPN
biomedich-119	382	2	,	,	PUNCT
biomedich-119	382	3	t.	t.	PROPN
biomedich-119	382	4	,	,	PUNCT
biomedich-119	382	5	parker	parker	PROPN
biomedich-119	382	6	,	,	PUNCT
biomedich-119	382	7	n.	n.	NOUN
biomedich-119	382	8	and	and	CCONJ
biomedich-119	382	9	ylä	ylä	PROPN
biomedich-119	382	10	-	-	PUNCT
biomedich-119	382	11	herttuala	herttuala	PROPN
biomedich-119	382	12	,	,	PUNCT
biomedich-119	382	13	s.	s.	PROPN
biomedich-119	382	14	,	,	PUNCT
biomedich-119	382	15	2013	2013	NUM
biomedich-119	382	16	.	.	PUNCT
biomedich-119	383	1	history	history	NOUN
biomedich-119	383	2	of	of	ADP
biomedich-119	383	3	gene	gene	NOUN
biomedich-119	383	4	therapy	therapy	NOUN
biomedich-119	383	5	.	.	PUNCT
biomedich-119	384	1	gene	gene	NOUN
biomedich-119	384	2	,	,	PUNCT
biomedich-119	384	3	525(2	525(2	NUM
biomedich-119	384	4	)	)	PUNCT
biomedich-119	384	5	,	,	PUNCT
biomedich-119	384	6	pp.162	pp.162	NOUN
biomedich-119	384	7	-	-	PUNCT
biomedich-119	384	8	169	169	NUM
biomedich-119	384	9	.	.	PUNCT
biomedich-119	385	1	wolff	wolff	PROPN
biomedich-119	385	2	,	,	PUNCT
biomedich-119	385	3	j.a	j.a	PROPN
biomedich-119	385	4	.	.	PROPN
biomedich-119	385	5	and	and	CCONJ
biomedich-119	385	6	lederberg	lederberg	PROPN
biomedich-119	385	7	,	,	PUNCT
biomedich-119	385	8	j.	j.	PROPN
biomedich-119	385	9	,	,	PUNCT
biomedich-119	385	10	1994	1994	NUM
biomedich-119	385	11	.	.	PUNCT
biomedich-119	386	1	an	an	DET
biomedich-119	386	2	early	early	ADJ
biomedich-119	386	3	history	history	NOUN
biomedich-119	386	4	of	of	ADP
biomedich-119	386	5	gene	gene	NOUN
biomedich-119	386	6	transfer	transfer	NOUN
biomedich-119	386	7	and	and	CCONJ
biomedich-119	386	8	therapy	therapy	NOUN
biomedich-119	386	9	.	.	PUNCT
biomedich-119	387	1	human	human	ADJ
biomedich-119	387	2	gene	gene	NOUN
biomedich-119	387	3	therapy	therapy	NOUN
biomedich-119	387	4	,	,	PUNCT
biomedich-119	387	5	5(4	5(4	NUM
biomedich-119	387	6	)	)	PUNCT
biomedich-119	387	7	,	,	PUNCT
biomedich-119	387	8	pp.469	pp.469	PROPN
biomedich-119	387	9	-	-	PROPN
biomedich-119	387	10	480	480	PROPN
biomedich-119	387	11	.	.	PUNCT
biomedich-119	388	1	wong	wong	PROPN
biomedich-119	388	2	,	,	PUNCT
biomedich-119	388	3	m.s	m.s	PROPN
biomedich-119	388	4	.	.	PROPN
biomedich-119	388	5	,	,	PUNCT
biomedich-119	388	6	hawthorne	hawthorne	PROPN
biomedich-119	388	7	,	,	PUNCT
biomedich-119	388	8	w.j	w.j	PROPN
biomedich-119	388	9	.	.	PROPN
biomedich-119	388	10	and	and	CCONJ
biomedich-119	388	11	manolios	manolios	PROPN
biomedich-119	388	12	,	,	PUNCT
biomedich-119	388	13	n.	n.	NOUN
biomedich-119	388	14	,	,	PUNCT
biomedich-119	388	15	2010	2010	NUM
biomedich-119	388	16	.	.	PUNCT
biomedich-119	389	1	gene	gene	NOUN
biomedich-119	389	2	therapy	therapy	NOUN
biomedich-119	389	3	in	in	ADP
biomedich-119	389	4	diabetes	diabetes	NOUN
biomedich-119	389	5	.	.	PUNCT
biomedich-119	390	1	self	self	NOUN
biomedich-119	390	2	/	/	SYM
biomedich-119	390	3	nonself	nonself	PROPN
biomedich-119	390	4	,	,	PUNCT
biomedich-119	390	5	1(3	1(3	NUM
biomedich-119	390	6	)	)	PUNCT
biomedich-119	390	7	,	,	PUNCT
biomedich-119	390	8	pp.165	pp.165	PROPN
biomedich-119	390	9	-	-	PUNCT
biomedich-119	390	10	175	175	NUM
biomedich-119	390	11	.	.	PUNCT
biomedich-119	391	1	yi	yi	PROPN
biomedich-119	391	2	,	,	PUNCT
biomedich-119	391	3	z.	z.	PROPN
biomedich-119	391	4	,	,	PUNCT
biomedich-119	391	5	waseem	waseem	PROPN
biomedich-119	391	6	ghani	ghani	PROPN
biomedich-119	391	7	,	,	PUNCT
biomedich-119	391	8	m.	m.	NOUN
biomedich-119	391	9	,	,	PUNCT
biomedich-119	391	10	ghani	ghani	PROPN
biomedich-119	391	11	,	,	PUNCT
biomedich-119	391	12	h.	h.	PROPN
biomedich-119	391	13	,	,	PUNCT
biomedich-119	391	14	jiang	jiang	PROPN
biomedich-119	391	15	,	,	PUNCT
biomedich-119	391	16	w.	w.	PROPN
biomedich-119	391	17	,	,	PUNCT
biomedich-119	391	18	waseem	waseem	PROPN
biomedich-119	391	19	birmani	birmani	PROPN
biomedich-119	391	20	,	,	PUNCT
biomedich-119	391	21	m.	m.	NOUN
biomedich-119	391	22	,	,	PUNCT
biomedich-119	391	23	ye	ye	PROPN
biomedich-119	391	24	,	,	PUNCT
biomedich-119	391	25	l.	l.	PROPN
biomedich-119	391	26	,	,	PUNCT
biomedich-119	391	27	bin	bin	PROPN
biomedich-119	391	28	,	,	PUNCT
biomedich-119	391	29	l.	l.	PROPN
biomedich-119	391	30	,	,	PUNCT
biomedich-119	391	31	cun	cun	PROPN
biomedich-119	391	32	,	,	PUNCT
biomedich-119	391	33	l.g	l.g	PROPN
biomedich-119	391	34	.	.	PROPN
biomedich-119	391	35	,	,	PUNCT
biomedich-119	391	36	lilong	lilong	PROPN
biomedich-119	391	37	,	,	PUNCT
biomedich-119	391	38	a.	a.	NOUN
biomedich-119	391	39	and	and	CCONJ
biomedich-119	391	40	mei	mei	PROPN
biomedich-119	391	41	,	,	PUNCT
biomedich-119	391	42	x.	x.	NOUN
biomedich-119	391	43	,	,	PUNCT
biomedich-119	391	44	2020	2020	NUM
biomedich-119	391	45	.	.	PUNCT
biomedich-119	392	1	gimmicks	gimmick	NOUN
biomedich-119	392	2	of	of	ADP
biomedich-119	392	3	gamma‐aminobutyric	gamma‐aminobutyric	ADJ
biomedich-119	392	4	acid	acid	NOUN
biomedich-119	392	5	(	(	PUNCT
biomedich-119	392	6	gaba	gaba	PROPN
biomedich-119	392	7	)	)	PUNCT
biomedich-119	392	8	in	in	ADP
biomedich-119	392	9	pancreatic	pancreatic	ADJ
biomedich-119	392	10	β‐cell	β‐cell	PUNCT
biomedich-119	392	11	regeneration	regeneration	NOUN
biomedich-119	392	12	through	through	ADP
biomedich-119	392	13	transdifferentiation	transdifferentiation	NOUN
biomedich-119	392	14	of	of	ADP
biomedich-119	392	15	pancreatic	pancreatic	ADJ
biomedich-119	392	16	α‐to	α‐to	NOUN
biomedich-119	392	17	β‐cells	β‐cells	PUNCT
biomedich-119	392	18	.	.	PUNCT
biomedich-119	392	19	cell	cell	NOUN
biomedich-119	392	20	biology	biology	NOUN
biomedich-119	392	21	international	international	ADJ
biomedich-119	392	22	,	,	PUNCT
biomedich-119	392	23	44(4	44(4	NOUN
biomedich-119	392	24	)	)	PUNCT
biomedich-119	392	25	,	,	PUNCT
biomedich-119	392	26	pp.926	pp.926	NOUN
biomedich-119	392	27	-	-	SYM
biomedich-119	392	28	936	936	NUM
biomedich-119	392	29	.	.	PUNCT
biomedich-119	392	30	yu	yu	PROPN
biomedich-119	392	31	,	,	PUNCT
biomedich-119	392	32	x.x	x.x	PROPN
biomedich-119	392	33	.	.	PROPN
biomedich-119	392	34	and	and	CCONJ
biomedich-119	392	35	xu	xu	PROPN
biomedich-119	392	36	,	,	PUNCT
biomedich-119	392	37	c.r	c.r	PROPN
biomedich-119	392	38	.	.	PROPN
biomedich-119	392	39	,	,	PUNCT
biomedich-119	392	40	2020	2020	NUM
biomedich-119	392	41	.	.	PUNCT
biomedich-119	393	1	understanding	understand	VERB
biomedich-119	393	2	generation	generation	NOUN
biomedich-119	393	3	and	and	CCONJ
biomedich-119	393	4	regeneration	regeneration	NOUN
biomedich-119	393	5	of	of	ADP
biomedich-119	393	6	pancreatic	pancreatic	ADJ
biomedich-119	393	7	β	β	NOUN
biomedich-119	393	8	cells	cell	NOUN
biomedich-119	393	9	from	from	ADP
biomedich-119	393	10	a	a	DET
biomedich-119	393	11	single	single	ADJ
biomedich-119	393	12	-	-	PUNCT
biomedich-119	393	13	cell	cell	NOUN
biomedich-119	393	14	perspective	perspective	NOUN
biomedich-119	393	15	.	.	PUNCT
biomedich-119	394	1	development	development	NOUN
biomedich-119	394	2	,	,	PUNCT
biomedich-119	394	3	147(7	147(7	NUM
biomedich-119	394	4	)	)	PUNCT
biomedich-119	394	5	.	.	PUNCT
biomedich-119	395	1	64	64	NUM
biomedich-119	395	2	biology	biology	NOUN
biomedich-119	395	3	,	,	PUNCT
biomedich-119	395	4	medicine	medicine	NOUN
biomedich-119	395	5	,	,	PUNCT
biomedich-119	395	6	&	&	CCONJ
biomedich-119	395	7	natural	natural	ADJ
biomedich-119	395	8	product	product	NOUN
biomedich-119	395	9	chemistry	chemistry	NOUN
biomedich-119	395	10	9	9	NUM
biomedich-119	395	11	(	(	PUNCT
biomedich-119	395	12	2	2	NUM
biomedich-119	395	13	)	)	PUNCT
biomedich-119	395	14	,	,	PUNCT
biomedich-119	395	15	2020	2020	NUM
biomedich-119	395	16	:	:	PUNCT
biomedich-119	395	17	57	57	NUM
biomedich-119	395	18	-	-	SYM
biomedich-119	395	19	64	64	NUM
biomedich-119	395	20	zarinsefat	zarinsefat	NOUN
biomedich-119	395	21	,	,	PUNCT
biomedich-119	395	22	a.	a.	NOUN
biomedich-119	395	23	and	and	CCONJ
biomedich-119	395	24	stock	stock	NOUN
biomedich-119	395	25	,	,	PUNCT
biomedich-119	395	26	p.g	p.g	PROPN
biomedich-119	395	27	.	.	PROPN
biomedich-119	395	28	,	,	PUNCT
biomedich-119	395	29	2020	2020	NUM
biomedich-119	395	30	.	.	PUNCT
biomedich-119	396	1	islet	islet	NOUN
biomedich-119	396	2	vs	vs	ADP
biomedich-119	396	3	pancreas	pancreas	NOUN
biomedich-119	396	4	transplantation	transplantation	NOUN
biomedich-119	396	5	in	in	ADP
biomedich-119	396	6	nonuremic	nonuremic	ADJ
biomedich-119	396	7	patients	patient	NOUN
biomedich-119	396	8	with	with	ADP
biomedich-119	396	9	type	type	NOUN
biomedich-119	396	10	1	1	NUM
biomedich-119	396	11	diabetes	diabetes	NOUN
biomedich-119	396	12	.	.	PUNCT
biomedich-119	397	1	in	in	ADP
biomedich-119	397	2	transplantation	transplantation	NOUN
biomedich-119	397	3	,	,	PUNCT
biomedich-119	397	4	bioengineering	bioengineering	NOUN
biomedich-119	397	5	,	,	PUNCT
biomedich-119	397	6	and	and	CCONJ
biomedich-119	397	7	regeneration	regeneration	NOUN
biomedich-119	397	8	of	of	ADP
biomedich-119	397	9	the	the	DET
biomedich-119	397	10	endocrine	endocrine	NOUN
biomedich-119	397	11	pancreas	pancreas	NOUN
biomedich-119	397	12	(	(	PUNCT
biomedich-119	397	13	pp	pp	ADJ
biomedich-119	397	14	.	.	PUNCT
biomedich-119	398	1	417	417	NUM
biomedich-119	398	2	-	-	SYM
biomedich-119	398	3	423	423	NUM
biomedich-119	398	4	)	)	PUNCT
biomedich-119	398	5	.	.	PUNCT
biomedich-119	399	1	academic	academic	ADJ
biomedich-119	399	2	press	press	NOUN
biomedich-119	399	3	.	.	PUNCT
biomedich-119	400	1	zhang	zhang	PROPN
biomedich-119	400	2	,	,	PUNCT
biomedich-119	400	3	j.	j.	PROPN
biomedich-119	400	4	and	and	CCONJ
biomedich-119	400	5	liu	liu	PROPN
biomedich-119	400	6	,	,	PUNCT
biomedich-119	400	7	f.	f.	PROPN
biomedich-119	400	8	,	,	PUNCT
biomedich-119	400	9	2020	2020	NUM
biomedich-119	400	10	,	,	PUNCT
biomedich-119	400	11	january	january	PROPN
biomedich-119	400	12	.	.	PUNCT
biomedich-119	401	1	the	the	DET
biomedich-119	401	2	de-	de-	PROPN
biomedich-119	401	3	,	,	PUNCT
biomedich-119	401	4	re-	re-	INTJ
biomedich-119	401	5	,	,	PUNCT
biomedich-119	401	6	and	and	CCONJ
biomedich-119	401	7	transdifferentiation	transdifferentiation	NOUN
biomedich-119	401	8	of	of	ADP
biomedich-119	401	9	β	β	NOUN
biomedich-119	401	10	-	-	NOUN
biomedich-119	401	11	cells	cell	NOUN
biomedich-119	401	12	:	:	PUNCT
biomedich-119	401	13	regulation	regulation	NOUN
biomedich-119	401	14	and	and	CCONJ
biomedich-119	401	15	function	function	NOUN
biomedich-119	401	16	.	.	PUNCT
biomedich-119	402	1	in	in	ADP
biomedich-119	402	2	seminars	seminar	NOUN
biomedich-119	402	3	in	in	ADP
biomedich-119	402	4	cell	cell	NOUN
biomedich-119	402	5	&	&	CCONJ
biomedich-119	402	6	developmental	developmental	ADJ
biomedich-119	402	7	biology	biology	NOUN
biomedich-119	402	8	.	.	PUNCT
biomedich-119	403	1	academic	academic	ADJ
biomedich-119	403	2	press	press	NOUN
biomedich-119	403	3	.	.	PUNCT
biomedich-119	404	1	zhou	zhou	PROPN
biomedich-119	404	2	,	,	PUNCT
biomedich-119	404	3	q.	q.	PROPN
biomedich-119	404	4	,	,	PUNCT
biomedich-119	404	5	brown	brown	PROPN
biomedich-119	404	6	,	,	PUNCT
biomedich-119	404	7	j.	j.	PROPN
biomedich-119	404	8	,	,	PUNCT
biomedich-119	404	9	kanarek	kanarek	PROPN
biomedich-119	404	10	,	,	PUNCT
biomedich-119	404	11	a.	a.	NOUN
biomedich-119	404	12	,	,	PUNCT
biomedich-119	404	13	rajagopal	rajagopal	PROPN
biomedich-119	404	14	,	,	PUNCT
biomedich-119	404	15	j.	j.	PROPN
biomedich-119	404	16	and	and	CCONJ
biomedich-119	404	17	melton	melton	PROPN
biomedich-119	404	18	,	,	PUNCT
biomedich-119	404	19	d.a	d.a	PROPN
biomedich-119	404	20	.	.	PROPN
biomedich-119	404	21	,	,	PUNCT
biomedich-119	404	22	2008	2008	NUM
biomedich-119	404	23	.	.	PUNCT
biomedich-119	405	1	in	in	ADP
biomedich-119	405	2	vivo	vivo	ADJ
biomedich-119	405	3	reprogramming	reprogramming	NOUN
biomedich-119	405	4	of	of	ADP
biomedich-119	405	5	adult	adult	NOUN
biomedich-119	405	6	pancreatic	pancreatic	ADJ
biomedich-119	405	7	exocrine	exocrine	NOUN
biomedich-119	405	8	cells	cell	NOUN
biomedich-119	405	9	to	to	ADP
biomedich-119	405	10	β	β	NOUN
biomedich-119	405	11	-	-	NOUN
biomedich-119	405	12	cells	cell	NOUN
biomedich-119	405	13	.	.	PUNCT
biomedich-119	406	1	nature	nature	NOUN
biomedich-119	406	2	,	,	PUNCT
biomedich-119	406	3	455(7213	455(7213	NUM
biomedich-119	406	4	)	)	PUNCT
biomedich-119	406	5	,	,	PUNCT
biomedich-119	406	6	pp.627	pp.627	PROPN
biomedich-119	406	7	-	-	PUNCT
biomedich-119	406	8	632	632	NUM
biomedich-119	406	9	.	.	PUNCT
biomedich-119	407	1	zhou	zhou	PROPN
biomedich-119	407	2	,	,	PUNCT
biomedich-119	407	3	x.	x.	PROPN
biomedich-119	407	4	,	,	PUNCT
biomedich-119	407	5	zhang	zhang	PROPN
biomedich-119	407	6	,	,	PUNCT
biomedich-119	407	7	s.	s.	PROPN
biomedich-119	407	8	,	,	PUNCT
biomedich-119	407	9	yu	yu	PROPN
biomedich-119	407	10	,	,	PUNCT
biomedich-119	407	11	f.	f.	PROPN
biomedich-119	407	12	,	,	PUNCT
biomedich-119	407	13	zhao	zhao	PROPN
biomedich-119	407	14	,	,	PUNCT
biomedich-119	407	15	g.	g.	PROPN
biomedich-119	407	16	,	,	PUNCT
biomedich-119	407	17	geng	geng	PROPN
biomedich-119	407	18	,	,	PUNCT
biomedich-119	407	19	s.	s.	PROPN
biomedich-119	407	20	,	,	PUNCT
biomedich-119	407	21	yu	yu	PROPN
biomedich-119	407	22	,	,	PUNCT
biomedich-119	407	23	w.	w.	PROPN
biomedich-119	407	24	,	,	PUNCT
biomedich-119	407	25	wang	wang	PROPN
biomedich-119	407	26	,	,	PUNCT
biomedich-119	407	27	x.y	x.y	PROPN
biomedich-119	407	28	.	.	PROPN
biomedich-119	407	29	and	and	CCONJ
biomedich-119	407	30	wang	wang	PROPN
biomedich-119	407	31	,	,	PUNCT
biomedich-119	407	32	b.	b.	PROPN
biomedich-119	407	33	,	,	PUNCT
biomedich-119	407	34	2020	2020	NUM
biomedich-119	407	35	.	.	PUNCT
biomedich-119	408	1	tolerogenic	tolerogenic	ADJ
biomedich-119	408	2	vaccine	vaccine	NOUN
biomedich-119	408	3	composited	composite	VERB
biomedich-119	408	4	with	with	ADP
biomedich-119	408	5	islet	islet	NOUN
biomedich-119	408	6	-	-	PUNCT
biomedich-119	408	7	derived	derive	VERB
biomedich-119	408	8	multipeptides	multipeptide	NOUN
biomedich-119	408	9	and	and	CCONJ
biomedich-119	408	10	cyclosporin	cyclosporin	NOUN
biomedich-119	408	11	a	a	DET
biomedich-119	408	12	induces	induce	NOUN
biomedich-119	408	13	ptreg	ptreg	NOUN
biomedich-119	408	14	and	and	CCONJ
biomedich-119	408	15	prevents	prevent	VERB
biomedich-119	408	16	type	type	NOUN
biomedich-119	408	17	1	1	NUM
biomedich-119	408	18	diabetes	diabetes	NOUN
biomedich-119	408	19	in	in	ADP
biomedich-119	408	20	murine	murine	ADJ
biomedich-119	408	21	model	model	NOUN
biomedich-119	408	22	.	.	PUNCT
biomedich-119	409	1	human	human	ADJ
biomedich-119	409	2	vaccines	vaccine	NOUN
biomedich-119	409	3	&	&	CCONJ
biomedich-119	409	4	immunotherapeutics	immunotherapeutic	NOUN
biomedich-119	409	5	,	,	PUNCT
biomedich-119	409	6	16(2	16(2	NUM
biomedich-119	409	7	)	)	PUNCT
biomedich-119	409	8	,	,	PUNCT
biomedich-119	409	9	pp.240	pp.240	PROPN
biomedich-119	409	10	-	-	PUNCT
biomedich-119	409	11	250	250	NUM
biomedich-119	409	12	.	.	PUNCT