id	sid	tid	token	lemma	pos
biomedich-205	1	1	biology	biology	NOUN
biomedich-205	1	2	,	,	PUNCT
biomedich-205	1	3	medicine	medicine	NOUN
biomedich-205	1	4	,	,	PUNCT
biomedich-205	1	5	&	&	CCONJ
biomedich-205	1	6	natural	natural	ADJ
biomedich-205	1	7	product	product	NOUN
biomedich-205	1	8	chemistry	chemistry	NOUN
biomedich-205	1	9	issn	issn	VERB
biomedich-205	1	10	2089	2089	NUM
biomedich-205	1	11	-	-	SYM
biomedich-205	1	12	6514	6514	NUM
biomedich-205	1	13	(	(	PUNCT
biomedich-205	1	14	paper	paper	NOUN
biomedich-205	1	15	)	)	PUNCT
biomedich-205	1	16	volume	volume	NOUN
biomedich-205	1	17	11	11	NUM
biomedich-205	1	18	,	,	PUNCT
biomedich-205	1	19	number	number	NOUN
biomedich-205	1	20	2	2	NUM
biomedich-205	1	21	,	,	PUNCT
biomedich-205	1	22	october	october	PROPN
biomedich-205	1	23	2022	2022	NUM
biomedich-205	1	24	|	|	ADV
biomedich-205	1	25	pages	page	NOUN
biomedich-205	1	26	:	:	PUNCT
biomedich-205	1	27	119	119	NUM
biomedich-205	1	28	-	-	SYM
biomedich-205	1	29	131	131	NUM
biomedich-205	1	30	|	|	ADV
biomedich-205	1	31	doi	doi	NOUN
biomedich-205	1	32	:	:	PUNCT
biomedich-205	1	33	10.14421	10.14421	NUM
biomedich-205	1	34	/	/	SYM
biomedich-205	1	35	biomedich.2022.112.119	biomedich.2022.112.119	NOUN
biomedich-205	1	36	-	-	SYM
biomedich-205	1	37	131	131	NUM
biomedich-205	1	38	issn	issn	PROPN
biomedich-205	1	39	2540	2540	NUM
biomedich-205	1	40	-	-	SYM
biomedich-205	1	41	9328	9328	NUM
biomedich-205	1	42	(	(	PUNCT
biomedich-205	1	43	online	online	ADJ
biomedich-205	1	44	)	)	PUNCT
biomedich-205	1	45	detection	detection	NOUN
biomedich-205	1	46	of	of	ADP
biomedich-205	1	47	the	the	DET
biomedich-205	1	48	atherosclerotic	atherosclerotic	ADJ
biomedich-205	1	49	pcsk9	pcsk9	NOUN
biomedich-205	1	50	gene	gene	NOUN
biomedich-205	1	51	inhibitors	inhibitor	NOUN
biomedich-205	1	52	through	through	ADP
biomedich-205	1	53	in	in	ADP
biomedich-205	1	54	silico	silico	NOUN
biomedich-205	1	55	method	method	NOUN
biomedich-205	1	56	to	to	PART
biomedich-205	1	57	improve	improve	VERB
biomedich-205	1	58	targeted	targeted	ADJ
biomedich-205	1	59	therapy	therapy	NOUN
biomedich-205	1	60	sabarinathan	sabarinathan	ADP
biomedich-205	1	61	sethuramalingam	sethuramalingam	PROPN
biomedich-205	1	62	,	,	PUNCT
biomedich-205	1	63	revathy	revathy	ADJ
biomedich-205	1	64	leena	leena	NOUN
biomedich-205	1	65	ravi	ravi	PROPN
biomedich-205	1	66	,	,	PUNCT
biomedich-205	1	67	janet	janet	PROPN
biomedich-205	1	68	rani	rani	PROPN
biomedich-205	1	69	rajiah	rajiah	PROPN
biomedich-205	1	70	*	*	PROPN
biomedich-205	1	71	sadakathullah	sadakathullah	PROPN
biomedich-205	1	72	appa	appa	PROPN
biomedich-205	1	73	college	college	NOUN
biomedich-205	1	74	,	,	PUNCT
biomedich-205	1	75	thirunelaveli	thirunelaveli	ADJ
biomedich-205	1	76	–	–	PUNCT
biomedich-205	1	77	627011	627011	NUM
biomedich-205	1	78	,	,	PUNCT
biomedich-205	1	79	india	india	PROPN
biomedich-205	1	80	corresponding	correspond	VERB
biomedich-205	1	81	author	author	NOUN
biomedich-205	1	82	*	*	PUNCT
biomedich-205	1	83	sethuraji90@gmail.com	sethuraji90@gmail.com	PROPN
biomedich-205	1	84	manuscript	manuscript	NOUN
biomedich-205	1	85	received	receive	VERB
biomedich-205	1	86	:	:	PUNCT
biomedich-205	1	87	27	27	NUM
biomedich-205	1	88	june	june	PROPN
biomedich-205	1	89	,	,	PUNCT
biomedich-205	1	90	2022	2022	NUM
biomedich-205	1	91	.	.	PUNCT
biomedich-205	2	1	revision	revision	NOUN
biomedich-205	2	2	accepted	accept	VERB
biomedich-205	2	3	:	:	PUNCT
biomedich-205	2	4	19	19	NUM
biomedich-205	2	5	july	july	PROPN
biomedich-205	2	6	,	,	PUNCT
biomedich-205	2	7	2022	2022	NUM
biomedich-205	2	8	.	.	PUNCT
biomedich-205	3	1	published	publish	VERB
biomedich-205	3	2	:	:	PUNCT
biomedich-205	3	3	31	31	NUM
biomedich-205	3	4	july	july	NOUN
biomedich-205	3	5	,	,	PUNCT
biomedich-205	3	6	2022	2022	NUM
biomedich-205	3	7	.	.	PUNCT
biomedich-205	4	1	abstract	abstract	ADJ
biomedich-205	4	2	the	the	DET
biomedich-205	4	3	pcsk9	pcsk9	NOUN
biomedich-205	4	4	is	be	AUX
biomedich-205	4	5	one	one	NUM
biomedich-205	4	6	of	of	ADP
biomedich-205	4	7	the	the	DET
biomedich-205	4	8	most	most	ADV
biomedich-205	4	9	important	important	ADJ
biomedich-205	4	10	marks	mark	NOUN
biomedich-205	4	11	for	for	ADP
biomedich-205	4	12	the	the	DET
biomedich-205	4	13	evolution	evolution	NOUN
biomedich-205	4	14	of	of	ADP
biomedich-205	4	15	therapeutic	therapeutic	ADJ
biomedich-205	4	16	agents	agent	NOUN
biomedich-205	4	17	for	for	ADP
biomedich-205	4	18	atherosclerosis	atherosclerosis	NOUN
biomedich-205	4	19	because	because	SCONJ
biomedich-205	4	20	its	its	PRON
biomedich-205	4	21	interaction	interaction	NOUN
biomedich-205	4	22	with	with	ADP
biomedich-205	4	23	lowdensity	lowdensity	NOUN
biomedich-205	4	24	lipoprotein	lipoprotein	ADJ
biomedich-205	4	25	receptors	receptor	NOUN
biomedich-205	4	26	causes	cause	VERB
biomedich-205	4	27	atherosclerosis	atherosclerosis	NOUN
biomedich-205	4	28	.	.	PUNCT
biomedich-205	5	1	protein	protein	NOUN
biomedich-205	5	2	-	-	PUNCT
biomedich-205	5	3	ligand	ligand	NOUN
biomedich-205	5	4	interactions	interaction	NOUN
biomedich-205	5	5	help	help	VERB
biomedich-205	5	6	us	we	PRON
biomedich-205	5	7	to	to	PART
biomedich-205	5	8	understand	understand	VERB
biomedich-205	5	9	the	the	DET
biomedich-205	5	10	true	true	ADJ
biomedich-205	5	11	mechanism	mechanism	NOUN
biomedich-205	5	12	of	of	ADP
biomedich-205	5	13	pharmacological	pharmacological	ADJ
biomedich-205	5	14	action	action	NOUN
biomedich-205	5	15	.	.	PUNCT
biomedich-205	6	1	this	this	DET
biomedich-205	6	2	study	study	NOUN
biomedich-205	6	3	seeks	seek	VERB
biomedich-205	6	4	to	to	PART
biomedich-205	6	5	identify	identify	VERB
biomedich-205	6	6	the	the	DET
biomedich-205	6	7	most	most	ADV
biomedich-205	6	8	powerful	powerful	ADJ
biomedich-205	6	9	suppression	suppression	NOUN
biomedich-205	6	10	options	option	NOUN
biomedich-205	6	11	for	for	ADP
biomedich-205	6	12	pcsk9	pcsk9	PROPN
biomedich-205	6	13	.	.	PUNCT
biomedich-205	7	1	initially	initially	ADV
biomedich-205	7	2	,	,	PUNCT
biomedich-205	7	3	the	the	DET
biomedich-205	7	4	reported	report	VERB
biomedich-205	7	5	ace	ace	NOUN
biomedich-205	7	6	inhibitors	inhibitor	NOUN
biomedich-205	7	7	were	be	AUX
biomedich-205	7	8	included	include	VERB
biomedich-205	7	9	in	in	ADP
biomedich-205	7	10	pharmacophore	pharmacophore	NOUN
biomedich-205	7	11	modeling	modeling	NOUN
biomedich-205	7	12	using	use	VERB
biomedich-205	7	13	pharmagist	pharmagist	NOUN
biomedich-205	7	14	.	.	PUNCT
biomedich-205	8	1	next	next	ADJ
biomedich-205	8	2	,	,	PUNCT
biomedich-205	8	3	zincpharmer	zincpharmer	PROPN
biomedich-205	8	4	was	be	AUX
biomedich-205	8	5	used	use	VERB
biomedich-205	8	6	to	to	PART
biomedich-205	8	7	screen	screen	VERB
biomedich-205	8	8	the	the	DET
biomedich-205	8	9	selected	select	VERB
biomedich-205	8	10	model	model	NOUN
biomedich-205	8	11	against	against	ADP
biomedich-205	8	12	a	a	DET
biomedich-205	8	13	zinc	zinc	NOUN
biomedich-205	8	14	database	database	NOUN
biomedich-205	8	15	to	to	PART
biomedich-205	8	16	identify	identify	VERB
biomedich-205	8	17	putative	putative	ADJ
biomedich-205	8	18	drug	drug	NOUN
biomedich-205	8	19	candidates	candidate	NOUN
biomedich-205	8	20	docked	dock	VERB
biomedich-205	8	21	to	to	ADP
biomedich-205	8	22	the	the	DET
biomedich-205	8	23	target	target	NOUN
biomedich-205	8	24	protein	protein	NOUN
biomedich-205	8	25	to	to	PART
biomedich-205	8	26	understand	understand	VERB
biomedich-205	8	27	the	the	DET
biomedich-205	8	28	interactions	interaction	NOUN
biomedich-205	8	29	.	.	PUNCT
biomedich-205	9	1	the	the	DET
biomedich-205	9	2	10	10	NUM
biomedich-205	9	3	best	good	ADJ
biomedich-205	9	4	pharmacological	pharmacological	ADJ
biomedich-205	9	5	candidates	candidate	NOUN
biomedich-205	9	6	for	for	ADP
biomedich-205	9	7	pcsk9	pcsk9	NOUN
biomedich-205	9	8	with	with	ADP
biomedich-205	9	9	a	a	DET
biomedich-205	9	10	binding	bind	VERB
biomedich-205	9	11	energy	energy	NOUN
biomedich-205	9	12	of	of	ADP
biomedich-205	9	13	9.8	9.8	NUM
biomedich-205	9	14	-	-	SYM
biomedich-205	9	15	8.2	8.2	NUM
biomedich-205	9	16	kcal	kcal	NOUN
biomedich-205	9	17	mol-1	mol-1	NUM
biomedich-205	9	18	were	be	AUX
biomedich-205	9	19	identified	identify	VERB
biomedich-205	9	20	by	by	ADP
biomedich-205	9	21	molecular	molecular	ADJ
biomedich-205	9	22	docking	docking	NOUN
biomedich-205	9	23	and	and	CCONJ
biomedich-205	9	24	their	their	PRON
biomedich-205	9	25	pharmacokinetic	pharmacokinetic	ADJ
biomedich-205	9	26	properties	property	NOUN
biomedich-205	9	27	and	and	CCONJ
biomedich-205	9	28	oral	oral	ADJ
biomedich-205	9	29	bioavailability	bioavailability	NOUN
biomedich-205	9	30	were	be	AUX
biomedich-205	9	31	evaluated	evaluate	VERB
biomedich-205	9	32	.	.	PUNCT
biomedich-205	10	1	the	the	DET
biomedich-205	10	2	(	(	PUNCT
biomedich-205	10	3	s	s	X
biomedich-205	10	4	)	)	PUNCT
biomedich-205	10	5	severalplant	severalplant	PROPN
biomedich-205	10	6	obtained	obtain	VERB
biomedich-205	10	7	chemicals	chemical	NOUN
biomedich-205	10	8	have	have	AUX
biomedich-205	10	9	been	be	AUX
biomedich-205	10	10	discovered	discover	VERB
biomedich-205	10	11	,	,	PUNCT
biomedich-205	10	12	including	include	VERB
biomedich-205	10	13	anti	anti	ADJ
biomedich-205	10	14	-	-	ADJ
biomedich-205	10	15	hypersensitive	hypersensitive	ADJ
biomedich-205	10	16	drugs	drug	NOUN
biomedich-205	10	17	such	such	ADJ
biomedich-205	10	18	as	as	ADP
biomedich-205	10	19	“	"	PUNCT
biomedich-205	10	20	canadine	canadine	NOUN
biomedich-205	10	21	,	,	PUNCT
biomedich-205	10	22	hesperetin	hesperetin	NOUN
biomedich-205	10	23	,	,	PUNCT
biomedich-205	10	24	and	and	CCONJ
biomedich-205	10	25	labetalol	labetalol	NOUN
biomedich-205	10	26	”	"	PUNCT
biomedich-205	10	27	.	.	PUNCT
biomedich-205	11	1	according	accord	VERB
biomedich-205	11	2	to	to	ADP
biomedich-205	11	3	biochemistry	biochemistry	NOUN
biomedich-205	11	4	,	,	PUNCT
biomedich-205	11	5	these	these	DET
biomedich-205	11	6	compounds	compound	NOUN
biomedich-205	11	7	formed	form	VERB
biomedich-205	11	8	a	a	DET
biomedich-205	11	9	stable	stable	ADJ
biomedich-205	11	10	“	"	PUNCT
biomedich-205	11	11	protein	protein	NOUN
biomedich-205	11	12	-	-	PUNCT
biomedich-205	11	13	ligand	ligand	NOUN
biomedich-205	11	14	”	"	PUNCT
biomedich-205	11	15	complex	complex	NOUN
biomedich-205	11	16	.	.	PUNCT
biomedich-205	12	1	the	the	DET
biomedich-205	12	2	(	(	PUNCT
biomedich-205	12	3	s	s	NOUN
biomedich-205	12	4	)	)	PUNCT
biomedich-205	12	5	canadine	canadine	NOUN
biomedich-205	12	6	pcsk9	pcsk9	PROPN
biomedich-205	12	7	complex	complex	NOUN
biomedich-205	12	8	had	have	VERB
biomedich-205	12	9	the	the	DET
biomedich-205	12	10	lowest	low	ADJ
biomedich-205	12	11	rmsd	rmsd	NOUN
biomedich-205	12	12	and	and	CCONJ
biomedich-205	12	13	was	be	AUX
biomedich-205	12	14	the	the	DET
biomedich-205	12	15	most	most	ADV
biomedich-205	12	16	stable	stable	ADJ
biomedich-205	12	17	.	.	PUNCT
biomedich-205	13	1	future	future	NOUN
biomedich-205	13	2	in	in	ADP
biomedich-205	13	3	vitro	vitro	X
biomedich-205	13	4	studies	study	NOUN
biomedich-205	13	5	could	could	AUX
biomedich-205	13	6	identify	identify	VERB
biomedich-205	13	7	(	(	PUNCT
biomedich-205	13	8	s	s	AUX
biomedich-205	13	9	)	)	PUNCT
biomedich-205	13	10	canadin	canadin	VERB
biomedich-205	13	11	as	as	ADP
biomedich-205	13	12	a	a	DET
biomedich-205	13	13	promising	promising	ADJ
biomedich-205	13	14	atherosclerosis	atherosclerosis	NOUN
biomedich-205	13	15	inhibitor	inhibitor	NOUN
biomedich-205	13	16	for	for	ADP
biomedich-205	13	17	the	the	DET
biomedich-205	13	18	evolution	evolution	NOUN
biomedich-205	13	19	of	of	ADP
biomedich-205	13	20	novel	novel	ADJ
biomedich-205	13	21	pcsk9	pcsk9	NOUN
biomedich-205	13	22	inhibitors	inhibitor	NOUN
biomedich-205	13	23	.	.	PUNCT
biomedich-205	14	1	keywords	keyword	NOUN
biomedich-205	14	2	:	:	PUNCT
biomedich-205	14	3	pcsk9	pcsk9	NOUN
biomedich-205	14	4	;	;	PUNCT
biomedich-205	14	5	therapeutics	therapeutic	NOUN
biomedich-205	14	6	;	;	PUNCT
biomedich-205	14	7	ace	ace	VERB
biomedich-205	14	8	inhibitors	inhibitor	NOUN
biomedich-205	14	9	;	;	PUNCT
biomedich-205	14	10	protein	protein	NOUN
biomedich-205	14	11	–	–	PUNCT
biomedich-205	14	12	ligand	ligand	ADJ
biomedich-205	14	13	;	;	PUNCT
biomedich-205	14	14	docking	docking	NOUN
biomedich-205	14	15	.	.	PUNCT
biomedich-205	15	1	introduction	introduction	NOUN
biomedich-205	15	2	highly	highly	ADV
biomedich-205	15	3	elevated	elevate	VERB
biomedich-205	15	4	ldl	ldl	NOUN
biomedich-205	15	5	cholesterol	cholesterol	NOUN
biomedich-205	15	6	known	know	VERB
biomedich-205	15	7	as	as	ADP
biomedich-205	15	8	“	"	PUNCT
biomedich-205	15	9	familial	familial	ADJ
biomedich-205	15	10	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	15	11	”	"	PUNCT
biomedich-205	15	12	(	(	PUNCT
biomedich-205	15	13	fh	fh	PROPN
biomedich-205	15	14	)	)	PUNCT
biomedich-205	15	15	is	be	AUX
biomedich-205	15	16	recognized	recognize	VERB
biomedich-205	15	17	as	as	ADP
biomedich-205	15	18	a	a	DET
biomedich-205	15	19	hereditable	hereditable	ADJ
biomedich-205	15	20	disease	disease	NOUN
biomedich-205	15	21	.	.	PUNCT
biomedich-205	16	1	it	it	PRON
biomedich-205	16	2	can	can	AUX
biomedich-205	16	3	lead	lead	VERB
biomedich-205	16	4	to	to	ADP
biomedich-205	16	5	an	an	DET
biomedich-205	16	6	increase	increase	NOUN
biomedich-205	16	7	of	of	ADP
biomedich-205	16	8	low	low	ADJ
biomedich-205	16	9	density	density	NOUN
biomedich-205	16	10	lipoprotein	lipoprotein	ADJ
biomedich-205	16	11	(	(	PUNCT
biomedich-205	16	12	ldl	ldl	NOUN
biomedich-205	16	13	)	)	PUNCT
biomedich-205	16	14	cholesterol	cholesterol	NOUN
biomedich-205	16	15	in	in	ADP
biomedich-205	16	16	the	the	DET
biomedich-205	16	17	blood	blood	NOUN
biomedich-205	16	18	.	.	PUNCT
biomedich-205	17	1	this	this	PRON
biomedich-205	17	2	can	can	AUX
biomedich-205	17	3	increase	increase	VERB
biomedich-205	17	4	ldl	ldl	NOUN
biomedich-205	17	5	quantity	quantity	NOUN
biomedich-205	17	6	by	by	ADP
biomedich-205	17	7	more	more	ADJ
biomedich-205	17	8	than	than	ADP
biomedich-205	17	9	4	4	NUM
biomedich-205	17	10	mmol	mmol	NOUN
biomedich-205	17	11	/	/	SYM
biomedich-205	17	12	l	l	NOUN
biomedich-205	17	13	(	(	PUNCT
biomedich-205	17	14	>	>	X
biomedich-205	17	15	180	180	NUM
biomedich-205	17	16	mg	mg	PROPN
biomedich-205	17	17	/	/	SYM
biomedich-205	17	18	dl	dl	PROPN
biomedich-205	17	19	)	)	PUNCT
biomedich-205	17	20	(	(	PUNCT
biomedich-205	17	21	zhao	zhao	PROPN
biomedich-205	17	22	et	et	PROPN
biomedich-205	17	23	al	al	PROPN
biomedich-205	17	24	.	.	PROPN
biomedich-205	17	25	,	,	PUNCT
biomedich-205	17	26	2019	2019	NUM
biomedich-205	17	27	)	)	PUNCT
biomedich-205	17	28	,	,	PUNCT
biomedich-205	17	29	increasing	increase	VERB
biomedich-205	17	30	the	the	DET
biomedich-205	17	31	threat	threat	NOUN
biomedich-205	17	32	of	of	ADP
biomedich-205	17	33	cardiovascular	cardiovascular	ADJ
biomedich-205	17	34	diseases	disease	NOUN
biomedich-205	17	35	(	(	PUNCT
biomedich-205	17	36	cvds	cvds	PROPN
biomedich-205	17	37	)	)	PUNCT
biomedich-205	17	38	such	such	ADJ
biomedich-205	17	39	as	as	ADP
biomedich-205	17	40	atherosclerosis	atherosclerosis	NOUN
biomedich-205	17	41	,	,	PUNCT
biomedich-205	17	42	heart	heart	NOUN
biomedich-205	17	43	failure	failure	NOUN
biomedich-205	17	44	and	and	CCONJ
biomedich-205	17	45	myocardial	myocardial	ADJ
biomedich-205	17	46	infarction	infarction	NOUN
biomedich-205	17	47	,	,	PUNCT
biomedich-205	17	48	etc	etc	X
biomedich-205	17	49	.	.	X
biomedich-205	17	50	patients	patient	NOUN
biomedich-205	17	51	with	with	ADP
biomedich-205	17	52	genetic	genetic	ADJ
biomedich-205	17	53	modification	modification	NOUN
biomedich-205	17	54	in	in	ADP
biomedich-205	17	55	the	the	DET
biomedich-205	17	56	familial	familial	ADJ
biomedich-205	17	57	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	17	58	gene	gene	NOUN
biomedich-205	17	59	,	,	PUNCT
biomedich-205	17	60	such	such	ADJ
biomedich-205	17	61	as	as	ADP
biomedich-205	17	62	low	low	ADJ
biomedich-205	17	63	density	density	NOUN
biomedich-205	17	64	lipoprotein	lipoprotein	ADJ
biomedich-205	17	65	receptor	receptor	NOUN
biomedich-205	17	66	(	(	PUNCT
biomedich-205	17	67	ldlr	ldlr	ADJ
biomedich-205	17	68	)	)	PUNCT
biomedich-205	17	69	,	,	PUNCT
biomedich-205	17	70	proprotein	proprotein	PROPN
biomedich-205	17	71	convertase	convertase	PROPN
biomedich-205	17	72	subtilisin	subtilisin	PROPN
biomedich-205	17	73	/	/	SYM
biomedich-205	17	74	kexin	kexin	NOUN
biomedich-205	17	75	type	type	NOUN
biomedich-205	17	76	9	9	NUM
biomedich-205	17	77	(	(	PUNCT
biomedich-205	17	78	pcsk9	pcsk9	NOUN
biomedich-205	17	79	)	)	PUNCT
biomedich-205	17	80	,	,	PUNCT
biomedich-205	17	81	and	and	CCONJ
biomedich-205	17	82	apob	apob	PROPN
biomedich-205	17	83	,	,	PUNCT
biomedich-205	17	84	are	be	AUX
biomedich-205	17	85	at	at	ADP
biomedich-205	17	86	increased	increase	VERB
biomedich-205	17	87	risk	risk	NOUN
biomedich-205	17	88	of	of	ADP
biomedich-205	17	89	atherosclerosis	atherosclerosis	NOUN
biomedich-205	17	90	(	(	PUNCT
biomedich-205	17	91	ascvd	ascvd	NOUN
biomedich-205	17	92	)	)	PUNCT
biomedich-205	17	93	than	than	ADP
biomedich-205	17	94	those	those	PRON
biomedich-205	17	95	without	without	ADP
biomedich-205	17	96	the	the	DET
biomedich-205	17	97	mutation	mutation	NOUN
biomedich-205	17	98	but	but	CCONJ
biomedich-205	17	99	with	with	ADP
biomedich-205	17	100	comparable	comparable	ADJ
biomedich-205	17	101	cholesterol	cholesterol	NOUN
biomedich-205	17	102	levels	level	NOUN
biomedich-205	17	103	(	(	PUNCT
biomedich-205	17	104	khera	khera	PROPN
biomedich-205	17	105	et	et	PROPN
biomedich-205	17	106	al	al	PROPN
biomedich-205	17	107	.	.	PROPN
biomedich-205	17	108	,	,	PUNCT
biomedich-205	17	109	2016	2016	NUM
biomedich-205	17	110	)	)	PUNCT
biomedich-205	17	111	.	.	PUNCT
biomedich-205	18	1	mutant	mutant	PROPN
biomedich-205	18	2	fh	fh	PROPN
biomedich-205	18	3	-	-	PUNCT
biomedich-205	18	4	related	relate	VERB
biomedich-205	18	5	genes	gene	NOUN
biomedich-205	18	6	can	can	AUX
biomedich-205	18	7	cause	cause	VERB
biomedich-205	18	8	an	an	DET
biomedich-205	18	9	increase	increase	NOUN
biomedich-205	18	10	in	in	ADP
biomedich-205	18	11	low	low	ADJ
biomedich-205	18	12	-	-	PUNCT
biomedich-205	18	13	density	density	NOUN
biomedich-205	18	14	lipoprotein	lipoprotein	ADJ
biomedich-205	18	15	cholesterol	cholesterol	NOUN
biomedich-205	18	16	(	(	PUNCT
biomedich-205	18	17	ldlc	ldlc	NOUN
biomedich-205	18	18	)	)	PUNCT
biomedich-205	18	19	(	(	PUNCT
biomedich-205	18	20	semenova	semenova	PROPN
biomedich-205	18	21	et	et	PROPN
biomedich-205	18	22	al	al	PROPN
biomedich-205	18	23	.	.	PROPN
biomedich-205	18	24	,	,	PUNCT
biomedich-205	18	25	2020	2020	NUM
biomedich-205	18	26	)	)	PUNCT
biomedich-205	18	27	,	,	PUNCT
biomedich-205	18	28	cause	cause	VERB
biomedich-205	18	29	vascular	vascular	ADJ
biomedich-205	18	30	endothelial	endothelial	ADJ
biomedich-205	18	31	dysfunction	dysfunction	NOUN
biomedich-205	18	32	.	.	PUNCT
biomedich-205	19	1	ascvd	ascvd	NOUN
biomedich-205	19	2	,	,	PUNCT
biomedich-205	19	3	including	include	VERB
biomedich-205	19	4	cad	cad	NOUN
biomedich-205	19	5	,	,	PUNCT
biomedich-205	19	6	is	be	AUX
biomedich-205	19	7	a	a	DET
biomedich-205	19	8	well	well	ADV
biomedich-205	19	9	-	-	PUNCT
biomedich-205	19	10	known	know	VERB
biomedich-205	19	11	disease	disease	NOUN
biomedich-205	19	12	characterized	characterize	VERB
biomedich-205	19	13	by	by	ADP
biomedich-205	19	14	endothelial	endothelial	ADJ
biomedich-205	19	15	dysfunction	dysfunction	NOUN
biomedich-205	19	16	.	.	PUNCT
biomedich-205	20	1	endothelial	endothelial	ADJ
biomedich-205	20	2	dysfunction	dysfunction	NOUN
biomedich-205	20	3	is	be	AUX
biomedich-205	20	4	the	the	DET
biomedich-205	20	5	first	first	ADJ
biomedich-205	20	6	step	step	NOUN
biomedich-205	20	7	in	in	ADP
biomedich-205	20	8	the	the	DET
biomedich-205	20	9	development	development	NOUN
biomedich-205	20	10	of	of	ADP
biomedich-205	20	11	atheroma	atheroma	NOUN
biomedich-205	20	12	.	.	PUNCT
biomedich-205	21	1	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	21	2	is	be	AUX
biomedich-205	21	3	one	one	NUM
biomedich-205	21	4	of	of	ADP
biomedich-205	21	5	the	the	DET
biomedich-205	21	6	most	most	ADV
biomedich-205	21	7	common	common	ADJ
biomedich-205	21	8	causes	cause	NOUN
biomedich-205	21	9	of	of	ADP
biomedich-205	21	10	endothelial	endothelial	ADJ
biomedich-205	21	11	dysfunction	dysfunction	NOUN
biomedich-205	21	12	that	that	PRON
biomedich-205	21	13	causes	cause	VERB
biomedich-205	21	14	stenosis	stenosis	NOUN
biomedich-205	21	15	of	of	ADP
biomedich-205	21	16	the	the	DET
biomedich-205	21	17	aorta	aorta	NOUN
biomedich-205	21	18	of	of	ADP
biomedich-205	21	19	the	the	DET
biomedich-205	21	20	heart	heart	NOUN
biomedich-205	21	21	(	(	PUNCT
biomedich-205	21	22	zhang	zhang	X
biomedich-205	21	23	et	et	PROPN
biomedich-205	21	24	al	al	PROPN
biomedich-205	21	25	.	.	PROPN
biomedich-205	21	26	,	,	PUNCT
biomedich-205	21	27	2020	2020	NUM
biomedich-205	21	28	)	)	PUNCT
biomedich-205	21	29	.	.	PUNCT
biomedich-205	22	1	cholesterol	cholesterol	NOUN
biomedich-205	22	2	is	be	AUX
biomedich-205	22	3	required	require	VERB
biomedich-205	22	4	for	for	ADP
biomedich-205	22	5	some	some	DET
biomedich-205	22	6	physiological	physiological	ADJ
biomedich-205	22	7	activities	activity	NOUN
biomedich-205	22	8	.	.	PUNCT
biomedich-205	23	1	cell	cell	NOUN
biomedich-205	23	2	membranes	membrane	NOUN
biomedich-205	23	3	are	be	AUX
biomedich-205	23	4	important	important	ADJ
biomedich-205	23	5	organelles	organelle	NOUN
biomedich-205	23	6	that	that	PRON
biomedich-205	23	7	require	require	VERB
biomedich-205	23	8	large	large	ADJ
biomedich-205	23	9	amounts	amount	NOUN
biomedich-205	23	10	of	of	ADP
biomedich-205	23	11	cholesterol	cholesterol	NOUN
biomedich-205	23	12	.	.	PUNCT
biomedich-205	24	1	in	in	ADP
biomedich-205	24	2	addition	addition	NOUN
biomedich-205	24	3	,	,	PUNCT
biomedich-205	24	4	cholesterol	cholesterol	NOUN
biomedich-205	24	5	is	be	AUX
biomedich-205	24	6	essential	essential	ADJ
biomedich-205	24	7	for	for	ADP
biomedich-205	24	8	the	the	DET
biomedich-205	24	9	production	production	NOUN
biomedich-205	24	10	of	of	ADP
biomedich-205	24	11	bile	bile	NOUN
biomedich-205	24	12	acid	acid	NOUN
biomedich-205	24	13	and	and	CCONJ
biomedich-205	24	14	steroid	steroid	NOUN
biomedich-205	24	15	hormones	hormone	NOUN
biomedich-205	24	16	.	.	PUNCT
biomedich-205	25	1	an	an	DET
biomedich-205	25	2	increase	increase	NOUN
biomedich-205	25	3	in	in	ADP
biomedich-205	25	4	cholesterol	cholesterol	NOUN
biomedich-205	25	5	,	,	PUNCT
biomedich-205	25	6	particularly	particularly	ADV
biomedich-205	25	7	under	under	ADP
biomedich-205	25	8	oxidizing	oxidize	VERB
biomedich-205	25	9	circumstances	circumstance	NOUN
biomedich-205	25	10	,	,	PUNCT
biomedich-205	25	11	may	may	AUX
biomedich-205	25	12	culminate	culminate	VERB
biomedich-205	25	13	in	in	ADP
biomedich-205	25	14	atherosclerosis	atherosclerosis	NOUN
biomedich-205	25	15	,	,	PUNCT
biomedich-205	25	16	causing	cause	VERB
biomedich-205	25	17	carotid	carotid	NOUN
biomedich-205	25	18	,	,	PUNCT
biomedich-205	25	19	peripheral	peripheral	ADJ
biomedich-205	25	20	artery	artery	NOUN
biomedich-205	25	21	,	,	PUNCT
biomedich-205	25	22	and	and	CCONJ
biomedich-205	25	23	coronary	coronary	ADJ
biomedich-205	25	24	heart	heart	NOUN
biomedich-205	25	25	disease	disease	NOUN
biomedich-205	25	26	(	(	PUNCT
biomedich-205	25	27	andreadou	andreadou	NOUN
biomedich-205	25	28	et	et	PROPN
biomedich-205	25	29	al	al	PROPN
biomedich-205	25	30	.	.	PROPN
biomedich-205	25	31	,	,	PUNCT
biomedich-205	25	32	2017	2017	NUM
biomedich-205	25	33	)	)	PUNCT
biomedich-205	25	34	.	.	PUNCT
biomedich-205	26	1	one	one	NUM
biomedich-205	26	2	of	of	ADP
biomedich-205	26	3	the	the	DET
biomedich-205	26	4	leading	lead	VERB
biomedich-205	26	5	causes	cause	NOUN
biomedich-205	26	6	of	of	ADP
biomedich-205	26	7	stroke	stroke	NOUN
biomedich-205	26	8	and	and	CCONJ
biomedich-205	26	9	heart	heart	NOUN
biomedich-205	26	10	attack	attack	NOUN
biomedich-205	26	11	is	be	AUX
biomedich-205	26	12	atherosclerosis	atherosclerosis	NOUN
biomedich-205	26	13	.	.	PUNCT
biomedich-205	27	1	cholesterol	cholesterol	NOUN
biomedich-205	27	2	buildup	buildup	NOUN
biomedich-205	27	3	may	may	AUX
biomedich-205	27	4	result	result	VERB
biomedich-205	27	5	in	in	ADP
biomedich-205	27	6	the	the	DET
biomedich-205	27	7	formation	formation	NOUN
biomedich-205	27	8	of	of	ADP
biomedich-205	27	9	arterial	arterial	ADJ
biomedich-205	27	10	plaques	plaque	NOUN
biomedich-205	27	11	,	,	PUNCT
biomedich-205	27	12	leading	lead	VERB
biomedich-205	27	13	to	to	ADP
biomedich-205	27	14	atherosclerosis	atherosclerosis	NOUN
biomedich-205	27	15	.	.	PUNCT
biomedich-205	28	1	elevations	elevation	NOUN
biomedich-205	28	2	in	in	ADP
biomedich-205	28	3	ldlc	ldlc	NOUN
biomedich-205	28	4	and	and	CCONJ
biomedich-205	28	5	apolipoprotein	apolipoprotein	VERB
biomedich-205	28	6	b100	b100	PROPN
biomedich-205	28	7	(	(	PUNCT
biomedich-205	28	8	apob100	apob100	PROPN
biomedich-205	28	9	)	)	PUNCT
biomedich-205	28	10	are	be	AUX
biomedich-205	28	11	precisely	precisely	ADV
biomedich-205	28	12	connected	connect	VERB
biomedich-205	28	13	to	to	ADP
biomedich-205	28	14	cardiovascular	cardiovascular	ADJ
biomedich-205	28	15	events	event	NOUN
biomedich-205	28	16	such	such	ADJ
biomedich-205	28	17	as	as	ADP
biomedich-205	28	18	atherosclerosis	atherosclerosis	NOUN
biomedich-205	28	19	.	.	PUNCT
biomedich-205	29	1	decreased	decrease	VERB
biomedich-205	29	2	ldlc	ldlc	NOUN
biomedich-205	29	3	levels	level	NOUN
biomedich-205	29	4	may	may	AUX
biomedich-205	29	5	reduce	reduce	VERB
biomedich-205	29	6	the	the	DET
biomedich-205	29	7	risk	risk	NOUN
biomedich-205	29	8	of	of	ADP
biomedich-205	29	9	cardiovascular	cardiovascular	ADJ
biomedich-205	29	10	events	event	NOUN
biomedich-205	29	11	,	,	PUNCT
biomedich-205	29	12	as	as	SCONJ
biomedich-205	29	13	reduction	reduction	NOUN
biomedich-205	29	14	of	of	ADP
biomedich-205	29	15	apob	apob	NOUN
biomedich-205	29	16	on	on	ADP
biomedich-205	29	17	the	the	DET
biomedich-205	29	18	arterial	arterial	NOUN
biomedich-205	29	19	wall	wall	NOUN
biomedich-205	29	20	can	can	AUX
biomedich-205	29	21	cause	cause	VERB
biomedich-205	29	22	lesion	lesion	NOUN
biomedich-205	29	23	and	and	CCONJ
biomedich-205	29	24	lead	lead	NOUN
biomedich-205	29	25	to	to	ADP
biomedich-205	29	26	the	the	DET
biomedich-205	29	27	formation	formation	NOUN
biomedich-205	29	28	of	of	ADP
biomedich-205	29	29	atherosclerosis	atherosclerosis	NOUN
biomedich-205	29	30	(	(	PUNCT
biomedich-205	29	31	mahley	mahley	NOUN
biomedich-205	29	32	,	,	PUNCT
biomedich-205	29	33	2016	2016	NUM
biomedich-205	29	34	)	)	PUNCT
biomedich-205	29	35	.	.	PUNCT
biomedich-205	30	1	ldlc	ldlc	NOUN
biomedich-205	30	2	deposits	deposit	NOUN
biomedich-205	30	3	can	can	AUX
biomedich-205	30	4	result	result	VERB
biomedich-205	30	5	in	in	ADP
biomedich-205	30	6	fatty	fatty	NOUN
biomedich-205	30	7	streaks	streak	NOUN
biomedich-205	30	8	accumulation	accumulation	NOUN
biomedich-205	30	9	and	and	CCONJ
biomedich-205	30	10	reduced	reduced	ADJ
biomedich-205	30	11	flow	flow	NOUN
biomedich-205	30	12	of	of	ADP
biomedich-205	30	13	blood	blood	NOUN
biomedich-205	30	14	to	to	ADP
biomedich-205	30	15	many	many	ADJ
biomedich-205	30	16	organs	organ	NOUN
biomedich-205	30	17	as	as	ADP
biomedich-205	30	18	a	a	DET
biomedich-205	30	19	result	result	NOUN
biomedich-205	30	20	of	of	ADP
biomedich-205	30	21	inflammatory	inflammatory	ADJ
biomedich-205	30	22	changes	change	NOUN
biomedich-205	30	23	in	in	ADP
biomedich-205	30	24	the	the	DET
biomedich-205	30	25	arterial	arterial	NOUN
biomedich-205	30	26	wall	wall	NOUN
biomedich-205	30	27	.	.	PUNCT
biomedich-205	31	1	pcsk9	pcsk9	PROPN
biomedich-205	31	2	interacts	interact	VERB
biomedich-205	31	3	with	with	ADP
biomedich-205	31	4	the	the	DET
biomedich-205	31	5	ldl	ldl	NOUN
biomedich-205	31	6	receptor	receptor	NOUN
biomedich-205	31	7	(	(	PUNCT
biomedich-205	31	8	ldlr	ldlr	ADJ
biomedich-205	31	9	)	)	PUNCT
biomedich-205	31	10	and	and	CCONJ
biomedich-205	31	11	causes	cause	VERB
biomedich-205	31	12	liposomal	liposomal	ADJ
biomedich-205	31	13	degradation	degradation	NOUN
biomedich-205	31	14	that	that	PRON
biomedich-205	31	15	promotes	promote	VERB
biomedich-205	31	16	atherosclerosis	atherosclerosis	NOUN
biomedich-205	31	17	.	.	PUNCT
biomedich-205	32	1	therefore	therefore	ADV
biomedich-205	32	2	,	,	PUNCT
biomedich-205	32	3	pcsk9	pcsk9	NOUN
biomedich-205	32	4	inhibition	inhibition	NOUN
biomedich-205	32	5	is	be	AUX
biomedich-205	32	6	essential	essential	ADJ
biomedich-205	32	7	for	for	ADP
biomedich-205	32	8	risk	risk	NOUN
biomedich-205	32	9	halting	halting	NOUN
biomedich-205	32	10	of	of	ADP
biomedich-205	32	11	cvds	cvds	PROPN
biomedich-205	32	12	(	(	PUNCT
biomedich-205	32	13	latimer	latimer	PROPN
biomedich-205	32	14	et	et	PROPN
biomedich-205	32	15	al	al	PROPN
biomedich-205	32	16	.	.	PROPN
biomedich-205	32	17	,	,	PUNCT
biomedich-205	32	18	2016	2016	NUM
biomedich-205	32	19	)	)	PUNCT
biomedich-205	32	20	.	.	PUNCT
biomedich-205	33	1	pcsk9	pcsk9	PROPN
biomedich-205	33	2	is	be	AUX
biomedich-205	33	3	a	a	DET
biomedich-205	33	4	protein	protein	NOUN
biomedich-205	33	5	with	with	ADP
biomedich-205	33	6	692	692	NUM
biomedich-205	33	7	amino	amino	ADJ
biomedich-205	33	8	acids	acid	NOUN
biomedich-205	33	9	which	which	PRON
biomedich-205	33	10	in	in	ADP
biomedich-205	33	11	mainly	mainly	ADV
biomedich-205	33	12	expressed	express	VERB
biomedich-205	33	13	in	in	ADP
biomedich-205	33	14	liver	liver	NOUN
biomedich-205	33	15	and	and	CCONJ
biomedich-205	33	16	intestine	intestine	NOUN
biomedich-205	33	17	(	(	PUNCT
biomedich-205	33	18	horton	horton	PROPN
biomedich-205	33	19	et	et	PROPN
biomedich-205	33	20	al	al	PROPN
biomedich-205	33	21	.	.	PROPN
biomedich-205	33	22	,	,	PUNCT
biomedich-205	33	23	2007	2007	NUM
biomedich-205	33	24	)	)	PUNCT
biomedich-205	33	25	.	.	PUNCT
biomedich-205	34	1	pcsk9	pcsk9	PROPN
biomedich-205	34	2	is	be	AUX
biomedich-205	34	3	synthesized	synthesize	VERB
biomedich-205	34	4	in	in	ADP
biomedich-205	34	5	the	the	DET
biomedich-205	34	6	endoplasmic	endoplasmic	ADJ
biomedich-205	34	7	reticulum	reticulum	NOUN
biomedich-205	34	8	(	(	PUNCT
biomedich-205	34	9	er	er	INTJ
biomedich-205	34	10	)	)	PUNCT
biomedich-205	34	11	,	,	PUNCT
biomedich-205	34	12	and	and	CCONJ
biomedich-205	34	13	its	its	PRON
biomedich-205	34	14	73	73	NUM
biomedich-205	34	15	kda	kda	NOUN
biomedich-205	34	16	precursor	precursor	NOUN
biomedich-205	34	17	peptide	peptide	NOUN
biomedich-205	34	18	is	be	AUX
biomedich-205	34	19	zymogen	zymogen	PROPN
biomedich-205	34	20	.	.	PUNCT
biomedich-205	35	1	this	this	DET
biomedich-205	35	2	zymogen	zymogen	NOUN
biomedich-205	35	3	makes	make	VERB
biomedich-205	35	4	many	many	ADJ
biomedich-205	35	5	changes	change	NOUN
biomedich-205	35	6	before	before	SCONJ
biomedich-205	35	7	it	it	PRON
biomedich-205	35	8	stick	stick	VERB
biomedich-205	35	9	out	out	ADP
biomedich-205	35	10	the	the	DET
biomedich-205	35	11	https://doi.org/10.14421/biomedich.2022.112.119-131	https://doi.org/10.14421/biomedich.2022.112.119-131	X
biomedich-205	35	12	mailto:sethuraji90@gmail.com	mailto:sethuraji90@gmail.com	X
biomedich-205	35	13	120	120	NUM
biomedich-205	35	14	biology	biology	NOUN
biomedich-205	35	15	,	,	PUNCT
biomedich-205	35	16	medicine	medicine	NOUN
biomedich-205	35	17	,	,	PUNCT
biomedich-205	35	18	&	&	CCONJ
biomedich-205	35	19	natural	natural	ADJ
biomedich-205	35	20	product	product	NOUN
biomedich-205	35	21	chemistry	chemistry	NOUN
biomedich-205	35	22	11	11	NUM
biomedich-205	35	23	(	(	PUNCT
biomedich-205	35	24	2	2	NUM
biomedich-205	35	25	)	)	PUNCT
biomedich-205	35	26	,	,	PUNCT
biomedich-205	35	27	2022	2022	NUM
biomedich-205	35	28	:	:	PUNCT
biomedich-205	35	29	119	119	NUM
biomedich-205	35	30	-	-	SYM
biomedich-205	35	31	131	131	NUM
biomedich-205	35	32	cell	cell	NOUN
biomedich-205	35	33	surface	surface	NOUN
biomedich-205	35	34	.	.	PUNCT
biomedich-205	36	1	there	there	PRON
biomedich-205	36	2	are	be	VERB
biomedich-205	36	3	auto	auto	NOUN
biomedich-205	36	4	-	-	PUNCT
biomedich-205	36	5	catalytic	catalytic	ADJ
biomedich-205	36	6	activity	activity	NOUN
biomedich-205	36	7	in	in	ADP
biomedich-205	36	8	-	-	PUNCT
biomedich-205	36	9	between	between	NOUN
biomedich-205	36	10	152nd	152nd	NOUN
biomedich-205	36	11	and	and	CCONJ
biomedich-205	36	12	153rd	153rd	ADJ
biomedich-205	36	13	amino	amino	NOUN
biomedich-205	36	14	acids	acid	NOUN
biomedich-205	36	15	.	.	PUNCT
biomedich-205	37	1	the	the	DET
biomedich-205	37	2	n	n	CCONJ
biomedich-205	37	3	-	-	PUNCT
biomedich-205	37	4	terminal	terminal	ADJ
biomedich-205	37	5	pro	pro	ADJ
biomedich-205	37	6	-	-	ADJ
biomedich-205	37	7	domain	domain	ADJ
biomedich-205	37	8	stays	stay	NOUN
biomedich-205	37	9	firmly	firmly	ADV
biomedich-205	37	10	linked	link	VERB
biomedich-205	37	11	with	with	ADP
biomedich-205	37	12	the	the	DET
biomedich-205	37	13	catalytic	catalytic	ADJ
biomedich-205	37	14	domain	domain	NOUN
biomedich-205	37	15	in	in	ADP
biomedich-205	37	16	the	the	DET
biomedich-205	37	17	secretory	secretory	ADJ
biomedich-205	37	18	route(hyock	route(hyock	PROPN
biomedich-205	37	19	et	et	PROPN
biomedich-205	37	20	al	al	PROPN
biomedich-205	37	21	.	.	PROPN
biomedich-205	37	22	,	,	PUNCT
biomedich-205	37	23	2008	2008	NUM
biomedich-205	37	24	)	)	PUNCT
biomedich-205	37	25	.	.	PUNCT
biomedich-205	38	1	pcsk9	pcsk9	PROPN
biomedich-205	38	2	can	can	AUX
biomedich-205	38	3	break	break	VERB
biomedich-205	38	4	ldlr	ldlr	ADJ
biomedich-205	38	5	with	with	ADP
biomedich-205	38	6	its	its	PRON
biomedich-205	38	7	proteolysis	proteolysis	NOUN
biomedich-205	38	8	activity	activity	NOUN
biomedich-205	38	9	when	when	SCONJ
biomedich-205	38	10	in	in	ADP
biomedich-205	38	11	contact	contact	NOUN
biomedich-205	38	12	with	with	ADP
biomedich-205	38	13	the	the	DET
biomedich-205	38	14	extra	extra	ADJ
biomedich-205	38	15	-	-	ADJ
biomedich-205	38	16	cellular	cellular	ADJ
biomedich-205	38	17	sites	site	NOUN
biomedich-205	38	18	of	of	ADP
biomedich-205	38	19	ldlr	ldlr	NOUN
biomedich-205	38	20	.	.	PUNCT
biomedich-205	39	1	pcsk9	pcsk9	PROPN
biomedich-205	39	2	has	have	VERB
biomedich-205	39	3	a	a	DET
biomedich-205	39	4	subtilisin	subtilisin	NOUN
biomedich-205	39	5	-	-	PUNCT
biomedich-205	39	6	like	like	ADJ
biomedich-205	39	7	catalytic	catalytic	ADJ
biomedich-205	39	8	domain	domain	NOUN
biomedich-205	39	9	that	that	PRON
biomedich-205	39	10	can	can	AUX
biomedich-205	39	11	bind	bind	VERB
biomedich-205	39	12	to	to	ADP
biomedich-205	39	13	the	the	DET
biomedich-205	39	14	ldlr	ldlr	PROPN
biomedich-205	39	15	-	-	PUNCT
biomedich-205	39	16	egfa	egfa	PROPN
biomedich-205	39	17	domain	domain	NOUN
biomedich-205	39	18	.	.	PUNCT
biomedich-205	40	1	this	this	DET
biomedich-205	40	2	domain	domain	NOUN
biomedich-205	40	3	contains	contain	VERB
biomedich-205	40	4	asp374	asp374	PROPN
biomedich-205	40	5	,	,	PUNCT
biomedich-205	40	6	and	and	CCONJ
biomedich-205	40	7	changing	change	VERB
biomedich-205	40	8	to	to	ADP
biomedich-205	40	9	tyr	tyr	PROPN
biomedich-205	40	10	increases	increase	VERB
biomedich-205	40	11	pcsk9	pcsk9	PROPN
biomedich-205	40	12	's	's	PART
biomedich-205	40	13	affinity	affinity	NOUN
biomedich-205	40	14	for	for	ADP
biomedich-205	40	15	ldlr	ldlr	PROPN
biomedich-205	40	16	(	(	PUNCT
biomedich-205	40	17	hyock	hyock	NOUN
biomedich-205	40	18	et	et	PROPN
biomedich-205	40	19	al	al	PROPN
biomedich-205	40	20	.	.	PROPN
biomedich-205	40	21	,	,	PUNCT
biomedich-205	40	22	2008	2008	NUM
biomedich-205	40	23	)	)	PUNCT
biomedich-205	40	24	.	.	PUNCT
biomedich-205	41	1	binding	bind	VERB
biomedich-205	41	2	of	of	ADP
biomedich-205	41	3	low	low	ADJ
biomedich-205	41	4	density	density	NOUN
biomedich-205	41	5	lipoprotein	lipoprotein	ADJ
biomedich-205	41	6	to	to	ADP
biomedich-205	41	7	low	low	ADJ
biomedich-205	41	8	density	density	NOUN
biomedich-205	41	9	lipoprotein	lipoprotein	ADJ
biomedich-205	41	10	receptor	receptor	NOUN
biomedich-205	41	11	is	be	AUX
biomedich-205	41	12	important	important	ADJ
biomedich-205	41	13	for	for	ADP
biomedich-205	41	14	reducing	reduce	VERB
biomedich-205	41	15	lipid	lipid	NOUN
biomedich-205	41	16	sedimentation	sedimentation	NOUN
biomedich-205	41	17	and	and	CCONJ
biomedich-205	41	18	the	the	DET
biomedich-205	41	19	threat	threat	NOUN
biomedich-205	41	20	of	of	ADP
biomedich-205	41	21	cvds	cvds	PROPN
biomedich-205	41	22	.	.	PUNCT
biomedich-205	42	1	when	when	SCONJ
biomedich-205	42	2	pcsk9	pcsk9	PROPN
biomedich-205	42	3	binds	bind	VERB
biomedich-205	42	4	to	to	PART
biomedich-205	42	5	ldlr	ldlr	VERB
biomedich-205	42	6	,	,	PUNCT
biomedich-205	42	7	it	it	PRON
biomedich-205	42	8	protects	protect	VERB
biomedich-205	42	9	ldl	ldl	NOUN
biomedich-205	42	10	from	from	ADP
biomedich-205	42	11	attaching	attach	VERB
biomedich-205	42	12	to	to	ADP
biomedich-205	42	13	low	low	ADJ
biomedich-205	42	14	density	density	NOUN
biomedich-205	42	15	lipoprotein	lipoprotein	ADJ
biomedich-205	42	16	(	(	PUNCT
biomedich-205	42	17	ldlr	ldlr	ADJ
biomedich-205	42	18	)	)	PUNCT
biomedich-205	42	19	and	and	CCONJ
biomedich-205	42	20	causes	cause	VERB
biomedich-205	42	21	lipid	lipid	NOUN
biomedich-205	42	22	sedimentation	sedimentation	NOUN
biomedich-205	42	23	.	.	PUNCT
biomedich-205	43	1	to	to	PART
biomedich-205	43	2	avoid	avoid	VERB
biomedich-205	43	3	cad	cad	PROPN
biomedich-205	43	4	,	,	PUNCT
biomedich-205	43	5	you	you	PRON
biomedich-205	43	6	should	should	AUX
biomedich-205	43	7	block	block	VERB
biomedich-205	43	8	the	the	DET
biomedich-205	43	9	association	association	NOUN
biomedich-205	43	10	between	between	ADP
biomedich-205	43	11	pcsk9	pcsk9	PROPN
biomedich-205	43	12	and	and	CCONJ
biomedich-205	43	13	its	its	PRON
biomedich-205	43	14	ldlr	ldlr	PROPN
biomedich-205	43	15	(	(	PUNCT
biomedich-205	43	16	horton	horton	PROPN
biomedich-205	43	17	et	et	PROPN
biomedich-205	43	18	al	al	PROPN
biomedich-205	43	19	.	.	PROPN
biomedich-205	43	20	,	,	PUNCT
biomedich-205	43	21	2009	2009	NUM
biomedich-205	43	22	)	)	PUNCT
biomedich-205	43	23	.	.	PUNCT
biomedich-205	44	1	natural	natural	ADJ
biomedich-205	44	2	treatments	treatment	NOUN
biomedich-205	44	3	using	use	VERB
biomedich-205	44	4	mab	mab	NOUN
biomedich-205	44	5	and	and	CCONJ
biomedich-205	44	6	short	short	ADJ
biomedich-205	44	7	molecule	molecule	NOUN
biomedich-205	44	8	drug	drug	NOUN
biomedich-205	44	9	therapies	therapy	NOUN
biomedich-205	44	10	are	be	AUX
biomedich-205	44	11	the	the	DET
biomedich-205	44	12	two	two	NUM
biomedich-205	44	13	main	main	ADJ
biomedich-205	44	14	approaches	approach	NOUN
biomedich-205	44	15	used	use	VERB
biomedich-205	44	16	in	in	ADP
biomedich-205	44	17	pcsk9	pcsk9	NOUN
biomedich-205	44	18	targeted	target	VERB
biomedich-205	44	19	therapies	therapy	NOUN
biomedich-205	44	20	.	.	PUNCT
biomedich-205	45	1	unfortunately	unfortunately	ADV
biomedich-205	45	2	,	,	PUNCT
biomedich-205	45	3	certain	certain	ADJ
biomedich-205	45	4	advances	advance	NOUN
biomedich-205	45	5	in	in	ADP
biomedich-205	45	6	small	small	ADJ
biomedich-205	45	7	molecule	molecule	NOUN
biomedich-205	45	8	drug	drug	NOUN
biomedich-205	45	9	therapy	therapy	NOUN
biomedich-205	45	10	for	for	ADP
biomedich-205	45	11	pcsk9	pcsk9	NOUN
biomedich-205	45	12	inhibition	inhibition	NOUN
biomedich-205	45	13	are	be	AUX
biomedich-205	45	14	hampered	hamper	VERB
biomedich-205	45	15	by	by	ADP
biomedich-205	45	16	the	the	DET
biomedich-205	45	17	fact	fact	NOUN
biomedich-205	45	18	that	that	SCONJ
biomedich-205	45	19	the	the	DET
biomedich-205	45	20	molecular	molecular	ADJ
biomedich-205	45	21	structure	structure	NOUN
biomedich-205	45	22	of	of	ADP
biomedich-205	45	23	pcsk9	pcsk9	PROPN
biomedich-205	45	24	required	require	VERB
biomedich-205	45	25	for	for	ADP
biomedich-205	45	26	small	small	ADJ
biomedich-205	45	27	molecule	molecule	NOUN
biomedich-205	45	28	binding	bind	VERB
biomedich-205	45	29	to	to	PART
biomedich-205	45	30	reduce	reduce	VERB
biomedich-205	45	31	the	the	DET
biomedich-205	45	32	activity	activity	NOUN
biomedich-205	45	33	of	of	ADP
biomedich-205	45	34	this	this	DET
biomedich-205	45	35	protein	protein	NOUN
biomedich-205	45	36	has	have	AUX
biomedich-205	45	37	not	not	PART
biomedich-205	45	38	been	be	AUX
biomedich-205	45	39	identified	identify	VERB
biomedich-205	45	40	(	(	PUNCT
biomedich-205	45	41	joseph	joseph	PROPN
biomedich-205	45	42	&	&	CCONJ
biomedich-205	45	43	robinson	robinson	PROPN
biomedich-205	45	44	,	,	PUNCT
biomedich-205	45	45	2015	2015	NUM
biomedich-205	45	46	)	)	PUNCT
biomedich-205	45	47	.	.	PUNCT
biomedich-205	46	1	computational	computational	ADJ
biomedich-205	46	2	methods	method	NOUN
biomedich-205	46	3	based	base	VERB
biomedich-205	46	4	on	on	ADP
biomedich-205	46	5	bioinformatics	bioinformatics	NOUN
biomedich-205	46	6	and	and	CCONJ
biomedich-205	46	7	chemoinformatics	chemoinformatics	AUX
biomedich-205	46	8	help	help	AUX
biomedich-205	46	9	identify	identify	VERB
biomedich-205	46	10	new	new	ADJ
biomedich-205	46	11	binding	bind	VERB
biomedich-205	46	12	sites	site	NOUN
biomedich-205	46	13	for	for	ADP
biomedich-205	46	14	inhibiting	inhibit	VERB
biomedich-205	46	15	proteins	protein	NOUN
biomedich-205	46	16	.	.	PUNCT
biomedich-205	47	1	bioinformatics	bioinformatic	NOUN
biomedich-205	47	2	and	and	CCONJ
biomedich-205	47	3	chemoinformatics	chemoinformatic	NOUN
biomedich-205	47	4	deal	deal	VERB
biomedich-205	47	5	with	with	ADP
biomedich-205	47	6	the	the	DET
biomedich-205	47	7	creation	creation	NOUN
biomedich-205	47	8	and	and	CCONJ
biomedich-205	47	9	manipulation	manipulation	NOUN
biomedich-205	47	10	of	of	ADP
biomedich-205	47	11	databases	database	NOUN
biomedich-205	47	12	and	and	CCONJ
biomedich-205	47	13	statistical	statistical	ADJ
biomedich-205	47	14	methods	method	NOUN
biomedich-205	47	15	for	for	ADP
biomedich-205	47	16	the	the	DET
biomedich-205	47	17	management	management	NOUN
biomedich-205	47	18	and	and	CCONJ
biomedich-205	47	19	analysis	analysis	NOUN
biomedich-205	47	20	of	of	ADP
biomedich-205	47	21	biological	biological	ADJ
biomedich-205	47	22	and	and	CCONJ
biomedich-205	47	23	chemical	chemical	NOUN
biomedich-205	47	24	data	datum	NOUN
biomedich-205	47	25	.	.	PUNCT
biomedich-205	48	1	these	these	DET
biomedich-205	48	2	devices	device	NOUN
biomedich-205	48	3	help	help	VERB
biomedich-205	48	4	to	to	PART
biomedich-205	48	5	find	find	VERB
biomedich-205	48	6	and	and	CCONJ
biomedich-205	48	7	study	study	VERB
biomedich-205	48	8	about	about	ADP
biomedich-205	48	9	targets	target	NOUN
biomedich-205	48	10	,	,	PUNCT
biomedich-205	48	11	chemical	chemical	NOUN
biomedich-205	48	12	structures	structure	NOUN
biomedich-205	48	13	,	,	PUNCT
biomedich-205	48	14	and	and	CCONJ
biomedich-205	48	15	mobile	mobile	NOUN
biomedich-205	48	16	sites	site	NOUN
biomedich-205	48	17	.	.	PUNCT
biomedich-205	49	1	these	these	DET
biomedich-205	49	2	devices	device	NOUN
biomedich-205	49	3	can	can	AUX
biomedich-205	49	4	also	also	ADV
biomedich-205	49	5	discover	discover	VERB
biomedich-205	49	6	potential	potential	ADJ
biomedich-205	49	7	medicinal	medicinal	ADJ
biomedich-205	49	8	molecules	molecule	NOUN
biomedich-205	49	9	for	for	ADP
biomedich-205	49	10	specific	specific	ADJ
biomedich-205	49	11	therapeutic	therapeutic	ADJ
biomedich-205	49	12	targets	target	NOUN
biomedich-205	49	13	and	and	CCONJ
biomedich-205	49	14	quantify	quantify	VERB
biomedich-205	49	15	their	their	PRON
biomedich-205	49	16	medicinal	medicinal	ADJ
biomedich-205	49	17	similarity	similarity	NOUN
biomedich-205	49	18	via	via	ADP
biomedich-205	49	19	molecular	molecular	ADJ
biomedich-205	49	20	docking	docking	NOUN
biomedich-205	49	21	(	(	PUNCT
biomedich-205	49	22	wishart	wishart	PROPN
biomedich-205	49	23	,	,	PUNCT
biomedich-205	49	24	2005	2005	NUM
biomedich-205	49	25	)	)	PUNCT
biomedich-205	49	26	.	.	PUNCT
biomedich-205	50	1	medicinal	medicinal	ADJ
biomedich-205	50	2	candidates	candidate	NOUN
biomedich-205	50	3	are	be	AUX
biomedich-205	50	4	evaluated	evaluate	VERB
biomedich-205	50	5	for	for	ADP
biomedich-205	50	6	their	their	PRON
biomedich-205	50	7	binding	bind	VERB
biomedich-205	50	8	affinity	affinity	NOUN
biomedich-205	50	9	and	and	CCONJ
biomedich-205	50	10	their	their	PRON
biomedich-205	50	11	properties	property	NOUN
biomedich-205	50	12	are	be	AUX
biomedich-205	50	13	subject	subject	ADJ
biomedich-205	50	14	to	to	ADP
biomedich-205	50	15	change	change	NOUN
biomedich-205	50	16	as	as	SCONJ
biomedich-205	50	17	needed	need	VERB
biomedich-205	50	18	.	.	PUNCT
biomedich-205	51	1	the	the	DET
biomedich-205	51	2	concept	concept	NOUN
biomedich-205	51	3	of	of	ADP
biomedich-205	51	4	computationally	computationally	ADV
biomedich-205	51	5	-	-	PUNCT
biomedich-205	51	6	based	base	VERB
biomedich-205	51	7	drug	drug	NOUN
biomedich-205	51	8	discovery	discovery	NOUN
biomedich-205	51	9	is	be	AUX
biomedich-205	51	10	called	call	VERB
biomedich-205	51	11	structural	structural	ADJ
biomedich-205	51	12	design	design	NOUN
biomedich-205	51	13	.	.	PUNCT
biomedich-205	52	1	therefore	therefore	ADV
biomedich-205	52	2	,	,	PUNCT
biomedich-205	52	3	the	the	DET
biomedich-205	52	4	in	in	ADP
biomedich-205	52	5	silico	silico	NOUN
biomedich-205	52	6	approach	approach	NOUN
biomedich-205	52	7	can	can	AUX
biomedich-205	52	8	provide	provide	VERB
biomedich-205	52	9	a	a	DET
biomedich-205	52	10	broad	broad	ADJ
biomedich-205	52	11	and	and	CCONJ
biomedich-205	52	12	favorable	favorable	ADJ
biomedich-205	52	13	approach	approach	NOUN
biomedich-205	52	14	for	for	ADP
biomedich-205	52	15	identifying	identify	VERB
biomedich-205	52	16	new	new	ADJ
biomedich-205	52	17	target	target	NOUN
biomedich-205	52	18	proteins	protein	NOUN
biomedich-205	52	19	and	and	CCONJ
biomedich-205	52	20	predicting	predict	VERB
biomedich-205	52	21	their	their	PRON
biomedich-205	52	22	biological	biological	ADJ
biomedich-205	52	23	activity	activity	NOUN
biomedich-205	52	24	(	(	PUNCT
biomedich-205	52	25	ramharack	ramharack	NOUN
biomedich-205	52	26	&	&	CCONJ
biomedich-205	52	27	soliman	soliman	PROPN
biomedich-205	52	28	,	,	PUNCT
biomedich-205	52	29	2018	2018	NUM
biomedich-205	52	30	)	)	PUNCT
biomedich-205	52	31	.	.	PUNCT
biomedich-205	53	1	the	the	DET
biomedich-205	53	2	drug	drug	NOUN
biomedich-205	53	3	components	component	NOUN
biomedich-205	53	4	such	such	ADJ
biomedich-205	53	5	as	as	ADP
biomedich-205	53	6	,	,	PUNCT
biomedich-205	53	7	“	"	PUNCT
biomedich-205	53	8	captopril	captopril	NOUN
biomedich-205	53	9	,	,	PUNCT
biomedich-205	53	10	zophonopril	zophonopril	NOUN
biomedich-205	53	11	,	,	PUNCT
biomedich-205	53	12	enalapril	enalapril	NOUN
biomedich-205	53	13	,	,	PUNCT
biomedich-205	53	14	ramipril	ramipril	NOUN
biomedich-205	53	15	,	,	PUNCT
biomedich-205	53	16	quinapril	quinapril	NOUN
biomedich-205	53	17	,	,	PUNCT
biomedich-205	53	18	perindopril	perindopril	ADJ
biomedich-205	53	19	,	,	PUNCT
biomedich-205	53	20	lisinopril	lisinopril	PROPN
biomedich-205	53	21	,	,	PUNCT
biomedich-205	53	22	benazepril	benazepril	ADJ
biomedich-205	53	23	,	,	PUNCT
biomedich-205	53	24	fosinopril	fosinopril	ADJ
biomedich-205	53	25	,	,	PUNCT
biomedich-205	53	26	sirazapril	sirazapril	NOUN
biomedich-205	53	27	,	,	PUNCT
biomedich-205	53	28	moexipril	moexipril	NOUN
biomedich-205	53	29	,	,	PUNCT
biomedich-205	53	30	trandolapril	trandolapril	PROPN
biomedich-205	53	31	,	,	PUNCT
biomedich-205	53	32	alicin	alicin	PROPN
biomedich-205	53	33	,	,	PUNCT
biomedich-205	53	34	teprotide	teprotide	ADJ
biomedich-205	53	35	”	"	PUNCT
biomedich-205	53	36	were	be	AUX
biomedich-205	53	37	used	use	VERB
biomedich-205	53	38	in	in	ADP
biomedich-205	53	39	this	this	DET
biomedich-205	53	40	incilico	incilico	ADJ
biomedich-205	53	41	study	study	NOUN
biomedich-205	53	42	(	(	PUNCT
biomedich-205	53	43	attique	attique	NOUN
biomedich-205	53	44	et	et	PROPN
biomedich-205	53	45	al	al	PROPN
biomedich-205	53	46	.	.	PROPN
biomedich-205	53	47	,	,	PUNCT
biomedich-205	53	48	2019	2019	NUM
biomedich-205	53	49	)	)	PUNCT
biomedich-205	53	50	.	.	PUNCT
biomedich-205	54	1	using	use	VERB
biomedich-205	54	2	computational	computational	ADJ
biomedich-205	54	3	approaches	approach	NOUN
biomedich-205	54	4	such	such	ADJ
biomedich-205	54	5	as	as	ADP
biomedich-205	54	6	the	the	DET
biomedich-205	54	7	pharmacophore	pharmacophore	ADJ
biomedich-205	54	8	design	design	NOUN
biomedich-205	54	9	of	of	ADP
biomedich-205	54	10	existing	exist	VERB
biomedich-205	54	11	drugs	drug	NOUN
biomedich-205	54	12	,	,	PUNCT
biomedich-205	54	13	new	new	ADJ
biomedich-205	54	14	small	small	ADJ
biomedich-205	54	15	inhibitors	inhibitor	NOUN
biomedich-205	54	16	of	of	ADP
biomedich-205	54	17	pcsk9	pcsk9	NOUN
biomedich-205	54	18	have	have	AUX
biomedich-205	54	19	been	be	AUX
biomedich-205	54	20	identified	identify	VERB
biomedich-205	54	21	.	.	PUNCT
biomedich-205	55	1	molecular	molecular	ADJ
biomedich-205	55	2	docking	docking	NOUN
biomedich-205	55	3	was	be	AUX
biomedich-205	55	4	performed	perform	VERB
biomedich-205	55	5	to	to	PART
biomedich-205	55	6	study	study	VERB
biomedich-205	55	7	the	the	DET
biomedich-205	55	8	interaction	interaction	NOUN
biomedich-205	55	9	of	of	ADP
biomedich-205	55	10	pcsk9	pcsk9	NOUN
biomedich-205	55	11	target	target	NOUN
biomedich-205	55	12	proteins	protein	NOUN
biomedich-205	55	13	with	with	ADP
biomedich-205	55	14	computer	computer	NOUN
biomedich-205	55	15	-	-	PUNCT
biomedich-205	55	16	identified	identify	VERB
biomedich-205	55	17	new	new	ADJ
biomedich-205	55	18	drugs	drug	NOUN
biomedich-205	55	19	.	.	PUNCT
biomedich-205	56	1	this	this	DET
biomedich-205	56	2	study	study	NOUN
biomedich-205	56	3	is	be	AUX
biomedich-205	56	4	essential	essential	ADJ
biomedich-205	56	5	for	for	ADP
biomedich-205	56	6	the	the	DET
biomedich-205	56	7	discovery	discovery	NOUN
biomedich-205	56	8	of	of	ADP
biomedich-205	56	9	new	new	ADJ
biomedich-205	56	10	drugs	drug	NOUN
biomedich-205	56	11	targeting	target	VERB
biomedich-205	56	12	pcsk9	pcsk9	NOUN
biomedich-205	56	13	that	that	PRON
biomedich-205	56	14	can	can	AUX
biomedich-205	56	15	be	be	AUX
biomedich-205	56	16	administered	administer	VERB
biomedich-205	56	17	to	to	PART
biomedich-205	56	18	cure	cure	VERB
biomedich-205	56	19	or	or	CCONJ
biomedich-205	56	20	reduce	reduce	VERB
biomedich-205	56	21	heart	heart	NOUN
biomedich-205	56	22	disease	disease	NOUN
biomedich-205	56	23	and	and	CCONJ
biomedich-205	56	24	address	address	VERB
biomedich-205	56	25	the	the	DET
biomedich-205	56	26	increasing	increase	VERB
biomedich-205	56	27	challenges	challenge	NOUN
biomedich-205	56	28	associated	associate	VERB
biomedich-205	56	29	with	with	ADP
biomedich-205	56	30	excess	excess	ADJ
biomedich-205	56	31	lipids	lipid	NOUN
biomedich-205	56	32	for	for	ADP
biomedich-205	56	33	the	the	DET
biomedich-205	56	34	reduction	reduction	NOUN
biomedich-205	56	35	and	and	CCONJ
biomedich-205	56	36	treatment	treatment	NOUN
biomedich-205	56	37	of	of	ADP
biomedich-205	56	38	atherosclerosis	atherosclerosis	NOUN
biomedich-205	56	39	or	or	CCONJ
biomedich-205	56	40	its	its	PRON
biomedich-205	56	41	symptoms	symptom	NOUN
biomedich-205	56	42	.	.	PUNCT
biomedich-205	57	1	materials	material	NOUN
biomedich-205	57	2	and	and	CCONJ
biomedich-205	57	3	methods	method	NOUN
biomedich-205	57	4	3d	3d	PROPN
biomedich-205	57	5	structure	structure	NOUN
biomedich-205	57	6	of	of	ADP
biomedich-205	57	7	the	the	DET
biomedich-205	57	8	protein	protein	NOUN
biomedich-205	57	9	of	of	ADP
biomedich-205	57	10	interest	interest	NOUN
biomedich-205	57	11	(	(	PUNCT
biomedich-205	57	12	pcsk9	pcsk9	PROPN
biomedich-205	57	13	)	)	PUNCT
biomedich-205	57	14	the	the	DET
biomedich-205	57	15	3d	3d	NUM
biomedich-205	57	16	structure	structure	NOUN
biomedich-205	57	17	of	of	ADP
biomedich-205	57	18	the	the	DET
biomedich-205	57	19	target	target	NOUN
biomedich-205	57	20	protein	protein	NOUN
biomedich-205	57	21	was	be	AUX
biomedich-205	57	22	obtained	obtain	VERB
biomedich-205	57	23	from	from	ADP
biomedich-205	57	24	the	the	DET
biomedich-205	57	25	pdb	pdb	PROPN
biomedich-205	57	26	library	library	NOUN
biomedich-205	57	27	(	(	PUNCT
biomedich-205	57	28	https://www.rcsb.org/search	https://www.rcsb.org/search	PROPN
biomedich-205	57	29	)	)	PUNCT
biomedich-205	57	30	(	(	PUNCT
biomedich-205	57	31	burley	burley	PROPN
biomedich-205	57	32	et	et	PROPN
biomedich-205	57	33	al	al	PROPN
biomedich-205	57	34	.	.	PROPN
biomedich-205	57	35	,	,	PUNCT
biomedich-205	57	36	2021	2021	NUM
biomedich-205	57	37	)	)	PUNCT
biomedich-205	57	38	.	.	PUNCT
biomedich-205	58	1	the	the	DET
biomedich-205	58	2	interaction	interaction	NOUN
biomedich-205	58	3	between	between	ADP
biomedich-205	58	4	the	the	DET
biomedich-205	58	5	egfa	egfa	PROPN
biomedich-205	58	6	domain	domain	NOUN
biomedich-205	58	7	of	of	ADP
biomedich-205	58	8	pcsk9	pcsk9	PROPN
biomedich-205	58	9	and	and	CCONJ
biomedich-205	58	10	ldlr	ldlr	PROPN
biomedich-205	58	11	occurs	occur	VERB
biomedich-205	58	12	at	at	ADP
biomedich-205	58	13	the	the	DET
biomedich-205	58	14	target	target	NOUN
biomedich-205	58	15	site	site	NOUN
biomedich-205	58	16	.	.	PUNCT
biomedich-205	59	1	this	this	DET
biomedich-205	59	2	interaction	interaction	NOUN
biomedich-205	59	3	(	(	PUNCT
biomedich-205	59	4	du	du	PROPN
biomedich-205	59	5	et	et	PROPN
biomedich-205	59	6	al	al	PROPN
biomedich-205	59	7	.	.	PROPN
biomedich-205	59	8	,	,	PUNCT
biomedich-205	59	9	2011	2011	NUM
biomedich-205	59	10	)	)	PUNCT
biomedich-205	59	11	between	between	ADP
biomedich-205	59	12	the	the	DET
biomedich-205	59	13	pro	pro	ADJ
biomedich-205	59	14	-	-	ADJ
biomedich-205	59	15	domain	domain	ADJ
biomedich-205	59	16	and	and	CCONJ
biomedich-205	59	17	c	c	NOUN
biomedich-205	59	18	-	-	PUNCT
biomedich-205	59	19	terminal	terminal	NOUN
biomedich-205	59	20	of	of	ADP
biomedich-205	59	21	pcsk9	pcsk9	PROPN
biomedich-205	59	22	increases	increase	VERB
biomedich-205	59	23	blood	blood	NOUN
biomedich-205	59	24	ldlc	ldlc	NOUN
biomedich-205	59	25	quantity	quantity	NOUN
biomedich-205	59	26	and	and	CCONJ
biomedich-205	59	27	thus	thus	ADV
biomedich-205	59	28	increases	increase	VERB
biomedich-205	59	29	susceptibility	susceptibility	NOUN
biomedich-205	59	30	to	to	ADP
biomedich-205	59	31	cvd	cvd	PROPN
biomedich-205	59	32	.	.	PUNCT
biomedich-205	60	1	the	the	DET
biomedich-205	60	2	pdb	pdb	PROPN
biomedich-205	60	3	i	i	PROPN
biomedich-205	60	4	d	d	PROPN
biomedich-205	60	5	6u26	6u26	NOUN
biomedich-205	60	6	(	(	PUNCT
biomedich-205	60	7	petrilli	petrilli	PROPN
biomedich-205	60	8	et	et	PROPN
biomedich-205	60	9	al	al	PROPN
biomedich-205	60	10	.	.	PROPN
biomedich-205	60	11	,	,	PUNCT
biomedich-205	60	12	2020	2020	NUM
biomedich-205	60	13	)	)	PUNCT
biomedich-205	60	14	was	be	AUX
biomedich-205	60	15	determined	determine	VERB
biomedich-205	60	16	based	base	VERB
biomedich-205	60	17	on	on	ADP
biomedich-205	60	18	its	its	PRON
biomedich-205	60	19	quality	quality	NOUN
biomedich-205	60	20	(	(	PUNCT
biomedich-205	60	21	1.49	1.49	NUM
biomedich-205	60	22	)	)	PUNCT
biomedich-205	60	23	after	after	ADP
biomedich-205	60	24	analyzing	analyze	VERB
biomedich-205	60	25	all	all	DET
biomedich-205	60	26	known	know	VERB
biomedich-205	60	27	structures	structure	NOUN
biomedich-205	60	28	in	in	ADP
biomedich-205	60	29	the	the	DET
biomedich-205	60	30	pdb	pdb	PROPN
biomedich-205	60	31	database	database	NOUN
biomedich-205	60	32	,	,	PUNCT
biomedich-205	60	33	including	include	VERB
biomedich-205	60	34	domains	domain	NOUN
biomedich-205	60	35	with	with	ADP
biomedich-205	60	36	one	one	NUM
biomedich-205	60	37	active	active	ADJ
biomedich-205	60	38	site	site	NOUN
biomedich-205	60	39	.	.	PUNCT
biomedich-205	61	1	pcsk9	pcsk9	PROPN
biomedich-205	61	2	active	active	ADJ
biomedich-205	61	3	site	site	NOUN
biomedich-205	61	4	characterization	characterization	NOUN
biomedich-205	61	5	the	the	DET
biomedich-205	61	6	active	active	ADJ
biomedich-205	61	7	site	site	NOUN
biomedich-205	61	8	of	of	ADP
biomedich-205	61	9	pcsk9	pcsk9	PROPN
biomedich-205	61	10	was	be	AUX
biomedich-205	61	11	found	find	VERB
biomedich-205	61	12	in	in	ADP
biomedich-205	61	13	-	-	PUNCT
biomedich-205	61	14	between	between	ADP
biomedich-205	61	15	a	a	DET
biomedich-205	61	16	unique	unique	ADJ
biomedich-205	61	17	pocket	pocket	NOUN
biomedich-205	61	18	,	,	PUNCT
biomedich-205	61	19	catalytic	catalytic	ADJ
biomedich-205	61	20	and	and	CCONJ
biomedich-205	61	21	c	c	NOUN
biomedich-205	61	22	-	-	PUNCT
biomedich-205	61	23	terminal	terminal	ADJ
biomedich-205	61	24	domain(petrilli	domain(petrilli	PROPN
biomedich-205	61	25	et	et	PROPN
biomedich-205	61	26	al	al	PROPN
biomedich-205	61	27	.	.	PROPN
biomedich-205	61	28	,	,	PUNCT
biomedich-205	61	29	2020	2020	NUM
biomedich-205	61	30	)	)	PUNCT
biomedich-205	61	31	.	.	PUNCT
biomedich-205	62	1	lig	lig	PROPN
biomedich-205	62	2	plot	plot	PROPN
biomedich-205	62	3	is	be	AUX
biomedich-205	62	4	used	use	VERB
biomedich-205	62	5	to	to	PART
biomedich-205	62	6	plot	plot	VERB
biomedich-205	62	7	this	this	DET
biomedich-205	62	8	pocket	pocket	NOUN
biomedich-205	62	9	(	(	PUNCT
biomedich-205	62	10	figure	figure	NOUN
biomedich-205	62	11	1	1	NUM
biomedich-205	62	12	)	)	PUNCT
biomedich-205	62	13	.	.	PUNCT
biomedich-205	63	1	ligplot	ligplot	NOUN
biomedich-205	63	2	provides	provide	VERB
biomedich-205	63	3	data	datum	NOUN
biomedich-205	63	4	on	on	ADP
biomedich-205	63	5	hydrogen	hydrogen	NOUN
biomedich-205	63	6	bonds	bond	NOUN
biomedich-205	63	7	and	and	CCONJ
biomedich-205	63	8	hydrophobic	hydrophobic	NOUN
biomedich-205	63	9	contacts	contact	NOUN
biomedich-205	63	10	(	(	PUNCT
biomedich-205	63	11	ra	ra	PROPN
biomedich-205	63	12	&	&	CCONJ
biomedich-205	63	13	mb	mb	ADP
biomedich-205	63	14	,	,	PUNCT
biomedich-205	63	15	2011	2011	NUM
biomedich-205	63	16	)	)	PUNCT
biomedich-205	63	17	.	.	PUNCT
biomedich-205	64	1	figure	figure	NOUN
biomedich-205	64	2	1	1	NUM
biomedich-205	64	3	.	.	PUNCT
biomedich-205	65	1	ligplot	ligplot	NOUN
biomedich-205	65	2	for	for	ADP
biomedich-205	65	3	6u26	6u26	ADV
biomedich-205	65	4	:	:	PUNCT
biomedich-205	65	5	(	(	PUNCT
biomedich-205	65	6	figure	figure	NOUN
biomedich-205	65	7	1	1	NUM
biomedich-205	65	8	)	)	PUNCT
biomedich-205	65	9	it	it	PRON
biomedich-205	65	10	shows	show	VERB
biomedich-205	65	11	data	datum	NOUN
biomedich-205	65	12	on	on	ADP
biomedich-205	65	13	hydrogen	hydrogen	NOUN
biomedich-205	65	14	bonds	bond	NOUN
biomedich-205	65	15	and	and	CCONJ
biomedich-205	65	16	hydrophobic	hydrophobic	NOUN
biomedich-205	65	17	contacts	contact	NOUN
biomedich-205	65	18	.	.	PUNCT
biomedich-205	66	1	preparation	preparation	NOUN
biomedich-205	66	2	of	of	ADP
biomedich-205	66	3	the	the	DET
biomedich-205	66	4	protein	protein	NOUN
biomedich-205	66	5	target	target	NOUN
biomedich-205	66	6	and	and	CCONJ
biomedich-205	66	7	ligand	ligand	VERB
biomedich-205	66	8	an	an	DET
biomedich-205	66	9	autodock	autodock	NOUN
biomedich-205	66	10	tool(hanwell	tool(hanwell	PROPN
biomedich-205	66	11	et	et	NOUN
biomedich-205	66	12	al	al	PROPN
biomedich-205	66	13	.	.	PROPN
biomedich-205	66	14	,	,	PUNCT
biomedich-205	66	15	2012	2012	NUM
biomedich-205	66	16	)	)	PUNCT
biomedich-205	66	17	was	be	AUX
biomedich-205	66	18	used	use	VERB
biomedich-205	66	19	to	to	PART
biomedich-205	66	20	purify	purify	VERB
biomedich-205	66	21	target	target	NOUN
biomedich-205	66	22	protein	protein	NOUN
biomedich-205	66	23	to	to	PART
biomedich-205	66	24	remove	remove	VERB
biomedich-205	66	25	heteroatom	heteroatom	NOUN
biomedich-205	66	26	,	,	PUNCT
biomedich-205	66	27	polar	polar	ADJ
biomedich-205	66	28	hydrogen	hydrogen	NOUN
biomedich-205	66	29	,	,	PUNCT
biomedich-205	66	30	and	and	CCONJ
biomedich-205	66	31	colman	colman	PROPN
biomedich-205	66	32	charges	charge	NOUN
biomedich-205	66	33	.	.	PUNCT
biomedich-205	67	1	the	the	DET
biomedich-205	67	2	3d	3d	NUM
biomedich-205	67	3	structure	structure	NOUN
biomedich-205	67	4	of	of	ADP
biomedich-205	67	5	the	the	DET
biomedich-205	67	6	pcsk9	pcsk9	PROPN
biomedich-205	67	7	target	target	NOUN
biomedich-205	67	8	protein	protein	NOUN
biomedich-205	67	9	was	be	AUX
biomedich-205	67	10	generated	generate	VERB
biomedich-205	67	11	by	by	ADP
biomedich-205	67	12	converting	convert	VERB
biomedich-205	67	13	to	to	ADP
biomedich-205	67	14	the	the	DET
biomedich-205	67	15	pdbqt	pdbqt	ADJ
biomedich-205	67	16	format	format	NOUN
biomedich-205	67	17	.	.	PUNCT
biomedich-205	68	1	angiotensin	angiotensin	NOUN
biomedich-205	68	2	-	-	PUNCT
biomedich-205	68	3	converting	convert	VERB
biomedich-205	68	4	enzyme	enzyme	NOUN
biomedich-205	68	5	sethuramalingam	sethuramalingam	NOUN
biomedich-205	68	6	et	et	PROPN
biomedich-205	68	7	al	al	PROPN
biomedich-205	68	8	.	.	PROPN
biomedich-205	69	1	–	–	PUNCT
biomedich-205	69	2	identification	identification	NOUN
biomedich-205	69	3	of	of	ADP
biomedich-205	69	4	pcsk9	pcsk9	NOUN
biomedich-205	69	5	inhibitors	inhibitor	VERB
biomedich-205	69	6	121	121	NUM
biomedich-205	69	7	inhibitor	inhibitor	NOUN
biomedich-205	69	8	(	(	PUNCT
biomedich-205	69	9	acei	acei	NOUN
biomedich-205	69	10	)	)	PUNCT
biomedich-205	69	11	with	with	ADP
biomedich-205	69	12	atherosclerosis	atherosclerosis	NOUN
biomedich-205	69	13	activity	activity	NOUN
biomedich-205	69	14	was	be	AUX
biomedich-205	69	15	found	find	VERB
biomedich-205	69	16	in	in	ADP
biomedich-205	69	17	ligand	ligand	ADJ
biomedich-205	69	18	synthesis	synthesis	NOUN
biomedich-205	69	19	(	(	PUNCT
biomedich-205	69	20	table	table	NOUN
biomedich-205	69	21	s1	s1	NOUN
biomedich-205	69	22	)	)	PUNCT
biomedich-205	69	23	.	.	PUNCT
biomedich-205	70	1	those	those	DET
biomedich-205	70	2	2	2	NUM
biomedich-205	70	3	dimensional	dimensional	ADJ
biomedich-205	70	4	structures	structure	NOUN
biomedich-205	70	5	were	be	AUX
biomedich-205	70	6	taken	take	VERB
biomedich-205	70	7	from	from	ADP
biomedich-205	70	8	the	the	DET
biomedich-205	70	9	pubchem	pubchem	NOUN
biomedich-205	70	10	database(kim	database(kim	PROPN
biomedich-205	70	11	et	et	PROPN
biomedich-205	70	12	al	al	PROPN
biomedich-205	70	13	.	.	PROPN
biomedich-205	70	14	,	,	PUNCT
biomedich-205	70	15	2021	2021	NUM
biomedich-205	70	16	)	)	PUNCT
biomedich-205	70	17	using	use	VERB
biomedich-205	70	18	individual	individual	ADJ
biomedich-205	70	19	pubchem	pubchem	NOUN
biomedich-205	70	20	ids	id	NOUN
biomedich-205	70	21	and	and	CCONJ
biomedich-205	70	22	energy	energy	NOUN
biomedich-205	70	23	was	be	AUX
biomedich-205	70	24	reduced	reduce	VERB
biomedich-205	70	25	using	use	VERB
biomedich-205	70	26	the	the	DET
biomedich-205	70	27	chemaxon	chemaxon	NOUN
biomedich-205	70	28	marvin	marvin	PROPN
biomedich-205	70	29	suite	suite	PROPN
biomedich-205	70	30	.	.	PUNCT
biomedich-205	71	1	we	we	PRON
biomedich-205	71	2	used	use	VERB
biomedich-205	71	3	raccoon	raccoon	NOUN
biomedich-205	71	4	software	software	NOUN
biomedich-205	71	5	(	(	PUNCT
biomedich-205	71	6	hanwell	hanwell	PROPN
biomedich-205	71	7	et	et	PROPN
biomedich-205	71	8	al	al	PROPN
biomedich-205	71	9	.	.	PROPN
biomedich-205	71	10	,	,	PUNCT
biomedich-205	71	11	2012	2012	NUM
biomedich-205	71	12	)	)	PUNCT
biomedich-205	71	13	to	to	PART
biomedich-205	71	14	convert	convert	VERB
biomedich-205	71	15	the	the	DET
biomedich-205	71	16	energy	energy	NOUN
biomedich-205	71	17	-	-	PUNCT
biomedich-205	71	18	optimized	optimize	VERB
biomedich-205	71	19	structure	structure	NOUN
biomedich-205	71	20	to	to	ADP
biomedich-205	71	21	pdbqt	pdbqt	NOUN
biomedich-205	71	22	format	format	NOUN
biomedich-205	71	23	.	.	PUNCT
biomedich-205	71	24	table	table	NOUN
biomedich-205	71	25	1	1	NUM
biomedich-205	71	26	.	.	PUNCT
biomedich-205	72	1	the	the	DET
biomedich-205	72	2	ei	ei	NOUN
biomedich-205	72	3	and	and	CCONJ
biomedich-205	72	4	pi	pi	NOUN
biomedich-205	72	5	of	of	ADP
biomedich-205	72	6	the	the	DET
biomedich-205	72	7	molecules	molecule	NOUN
biomedich-205	72	8	.	.	PUNCT
biomedich-205	73	1	molecule	molecule	NOUN
biomedich-205	73	2	name	name	NOUN
biomedich-205	73	3	pubchem	pubchem	NOUN
biomedich-205	73	4	i	i	PRON
biomedich-205	73	5	d	d	PROPN
biomedich-205	73	6	binding	bind	VERB
biomedich-205	73	7	energy	energy	NOUN
biomedich-205	73	8	residues	residue	NOUN
biomedich-205	73	9	ei	ei	ADP
biomedich-205	73	10	pi	pi	PROPN
biomedich-205	73	11	captopril/	captopril/	NUM
biomedich-205	73	12	44093	44093	NUM
biomedich-205	73	13	-7.0	-7.0	PROPN
biomedich-205	73	14	asp	asp	PROPN
biomedich-205	73	15	651	651	NUM
biomedich-205	73	16	and	and	CCONJ
biomedich-205	73	17	arg	arg	VERB
biomedich-205	73	18	545	545	NUM
biomedich-205	73	19	0.60	0.60	NUM
biomedich-205	73	20	0.98	0.98	NUM
biomedich-205	73	21	zofenopri	zofenopri	NOUN
biomedich-205	73	22	92400	92400	NUM
biomedich-205	73	23	-9.3	-9.3	NOUN
biomedich-205	73	24	arg	arg	VERB
biomedich-205	73	25	458	458	NUM
biomedich-205	73	26	and	and	CCONJ
biomedich-205	73	27	trp	trp	PROPN
biomedich-205	73	28	461	461	NUM
biomedich-205	73	29	0.24	0.24	NUM
biomedich-205	73	30	0.89	0.89	NUM
biomedich-205	73	31	enalapril	enalapril	NOUN
biomedich-205	73	32	5388962	5388962	NUM
biomedich-205	73	33	-8.8	-8.8	PROPN
biomedich-205	73	34	arg	arg	NOUN
biomedich-205	73	35	458	458	NUM
biomedich-205	73	36	0.28	0.28	NUM
biomedich-205	73	37	0.80	0.80	NUM
biomedich-205	73	38	ramipril/	ramipril/	NUM
biomedich-205	73	39	5362129	5362129	NUM
biomedich-205	73	40	-9.4	-9.4	NOUN
biomedich-205	73	41	arg	arg	VERB
biomedich-205	73	42	458	458	NUM
biomedich-205	73	43	0.33	0.33	NUM
biomedich-205	73	44	0.88	0.88	NUM
biomedich-205	73	45	quinapril	quinapril	NOUN
biomedich-205	73	46	54892	54892	NUM
biomedich-205	73	47	-9.9	-9.9	NOUN
biomedich-205	73	48	arg	arg	VERB
biomedich-205	73	49	458	458	NUM
biomedich-205	73	50	0.24	0.24	NUM
biomedich-205	73	51	0.60	0.60	NUM
biomedich-205	73	52	perindopril	perindopril	ADJ
biomedich-205	73	53	107807	107807	NUM
biomedich-205	73	54	-8.2	-8.2	PROPN
biomedich-205	73	55	arg	arg	VERB
biomedich-205	73	56	458	458	NUM
biomedich-205	73	57	0.30	0.30	NUM
biomedich-205	73	58	0.93	0.93	NUM
biomedich-205	73	59	lisinopril	lisinopril	NOUN
biomedich-205	73	60	5362119	5362119	NUM
biomedich-205	73	61	-8.8	-8.8	NOUN
biomedich-205	73	62	arg	arg	VERB
biomedich-205	73	63	458	458	NUM
biomedich-205	73	64	0.49	0.49	NUM
biomedich-205	73	65	0.92	0.92	NUM
biomedich-205	73	66	benazepri	benazepri	NOUN
biomedich-205	73	67	5362124	5362124	NUM
biomedich-205	73	68	-8.3	-8.3	ADJ
biomedich-205	73	69	arg	arg	NOUN
biomedich-205	73	70	458	458	NUM
biomedich-205	73	71	and	and	CCONJ
biomedich-205	73	72	arg	arg	VERB
biomedich-205	73	73	476	476	NUM
biomedich-205	73	74	0.51	0.51	NUM
biomedich-205	73	75	2.03	2.03	NUM
biomedich-205	73	76	fosinopri	fosinopri	NOUN
biomedich-205	73	77	55891	55891	NUM
biomedich-205	73	78	-8.7	-8.7	SYM
biomedich-205	73	79	arg	arg	VERB
biomedich-205	73	80	357	357	NUM
biomedich-205	73	81	0.08	0.08	NUM
biomedich-205	73	82	0.74	0.74	NUM
biomedich-205	73	83	cilazapril	cilazapril	NOUN
biomedich-205	73	84	56330	56330	NUM
biomedich-205	73	85	-9.6	-9.6	NOUN
biomedich-205	73	86	arg	arg	VERB
biomedich-205	73	87	458	458	NUM
biomedich-205	73	88	0.09	0.09	NUM
biomedich-205	73	89	0.46	0.46	NUM
biomedich-205	73	90	moexipril	moexipril	NOUN
biomedich-205	73	91	91270	91270	NUM
biomedich-205	73	92	-9.4	-9.4	NOUN
biomedich-205	73	93	arg	arg	VERB
biomedich-205	73	94	458	458	NUM
biomedich-205	73	95	0.27	0.27	NUM
biomedich-205	73	96	0.86	0.86	NUM
biomedich-205	73	97	trandolapril	trandolapril	NOUN
biomedich-205	73	98	5484727	5484727	NUM
biomedich-205	74	1	-9.1	-9.1	PROPN
biomedich-205	74	2	arg	arg	VERB
biomedich-205	74	3	458	458	NUM
biomedich-205	74	4	2.52	2.52	NUM
biomedich-205	74	5	2.40	2.40	NUM
biomedich-205	74	6	allicin	allicin	NOUN
biomedich-205	74	7	65036	65036	NUM
biomedich-205	74	8	-9.9	-9.9	PUNCT
biomedich-205	74	9	arg	arg	VERB
biomedich-205	74	10	458	458	NUM
biomedich-205	74	11	2.35	2.35	NUM
biomedich-205	74	12	2.68	2.68	NUM
biomedich-205	74	13	teprotide	teprotide	ADJ
biomedich-205	74	14	443376	443376	NUM
biomedich-205	74	15	-9.7	-9.7	PUNCT
biomedich-205	74	16	arg	arg	NOUN
biomedich-205	74	17	458	458	NUM
biomedich-205	74	18	,	,	PUNCT
biomedich-205	74	19	arg	arg	NOUN
biomedich-205	74	20	357	357	NUM
biomedich-205	74	21	,	,	PUNCT
biomedich-205	74	22	asn	asn	PROPN
biomedich-205	74	23	298	298	NUM
biomedich-205	74	24	,	,	PUNCT
biomedich-205	74	25	trp	trp	PROPN
biomedich-205	74	26	461	461	NUM
biomedich-205	74	27	,	,	PUNCT
biomedich-205	74	28	cys	cys	PROPN
biomedich-205	74	29	323	323	NUM
biomedich-205	74	30	and	and	CCONJ
biomedich-205	74	31	arg	arg	VERB
biomedich-205	74	32	458	458	NUM
biomedich-205	74	33	2.77	2.77	NUM
biomedich-205	74	34	2.67	2.67	NUM
biomedich-205	74	35	(	(	PUNCT
biomedich-205	74	36	table	table	NOUN
biomedich-205	74	37	1	1	NUM
biomedich-205	74	38	)	)	PUNCT
biomedich-205	74	39	it	it	PRON
biomedich-205	74	40	shows	show	VERB
biomedich-205	74	41	the	the	DET
biomedich-205	74	42	ei	ei	NOUN
biomedich-205	74	43	and	and	CCONJ
biomedich-205	74	44	pi	pi	NOUN
biomedich-205	74	45	of	of	ADP
biomedich-205	74	46	the	the	DET
biomedich-205	74	47	molecules	molecule	NOUN
biomedich-205	74	48	with	with	ADP
biomedich-205	74	49	its	its	PRON
biomedich-205	74	50	binding	bind	VERB
biomedich-205	74	51	energy	energy	NOUN
biomedich-205	74	52	.	.	PUNCT
biomedich-205	75	1	molecular	molecular	ADJ
biomedich-205	75	2	docking	docking	NOUN
biomedich-205	75	3	of	of	ADP
biomedich-205	75	4	recognised	recognise	VERB
biomedich-205	75	5	ace	ace	NOUN
biomedich-205	75	6	inhibitors	inhibitor	NOUN
biomedich-205	75	7	with	with	ADP
biomedich-205	75	8	psck9	psck9	NOUN
biomedich-205	75	9	the	the	DET
biomedich-205	75	10	energy	energy	NOUN
biomedich-205	75	11	-	-	PUNCT
biomedich-205	75	12	reducing	reduce	VERB
biomedich-205	75	13	structure	structure	NOUN
biomedich-205	75	14	(	(	PUNCT
biomedich-205	75	15	pdbqt	pdbqt	NOUN
biomedich-205	75	16	format	format	NOUN
biomedich-205	75	17	)	)	PUNCT
biomedich-205	75	18	was	be	AUX
biomedich-205	75	19	docked	dock	VERB
biomedich-205	75	20	to	to	ADP
biomedich-205	75	21	the	the	DET
biomedich-205	75	22	target	target	NOUN
biomedich-205	75	23	protein	protein	NOUN
biomedich-205	75	24	using	use	VERB
biomedich-205	75	25	autodock	autodock	NOUN
biomedich-205	75	26	vina	vina	NOUN
biomedich-205	75	27	(	(	PUNCT
biomedich-205	75	28	ukuku	ukuku	VERB
biomedich-205	75	29	et	et	NOUN
biomedich-205	75	30	al	al	PROPN
biomedich-205	75	31	.	.	PROPN
biomedich-205	75	32	,	,	PUNCT
biomedich-205	75	33	2012	2012	NUM
biomedich-205	75	34	)	)	PUNCT
biomedich-205	75	35	.	.	PUNCT
biomedich-205	76	1	all	all	DET
biomedich-205	76	2	known	know	VERB
biomedich-205	76	3	molecules	molecule	NOUN
biomedich-205	76	4	with	with	ADP
biomedich-205	76	5	above	above	ADP
biomedich-205	76	6	average	average	ADJ
biomedich-205	76	7	binding	bind	VERB
biomedich-205	76	8	energies	energy	NOUN
biomedich-205	76	9	(	(	PUNCT
biomedich-205	76	10	moexipril	moexipril	NOUN
biomedich-205	76	11	,	,	PUNCT
biomedich-205	76	12	trandolapril	trandolapril	PROPN
biomedich-205	76	13	,	,	PUNCT
biomedich-205	76	14	allicin	allicin	NOUN
biomedich-205	76	15	,	,	PUNCT
biomedich-205	76	16	teprotide	teprotide	ADJ
biomedich-205	76	17	,	,	PUNCT
biomedich-205	76	18	zophenapril	zophenapril	NOUN
biomedich-205	76	19	,	,	PUNCT
biomedich-205	76	20	lamapril	lamapril	NOUN
biomedich-205	76	21	,	,	PUNCT
biomedich-205	76	22	quinapril	quinapril	NOUN
biomedich-205	76	23	)	)	PUNCT
biomedich-205	76	24	were	be	AUX
biomedich-205	76	25	selected	select	VERB
biomedich-205	76	26	for	for	ADP
biomedich-205	76	27	the	the	DET
biomedich-205	76	28	pharmacophore	pharmacophore	NOUN
biomedich-205	76	29	design	design	NOUN
biomedich-205	76	30	.	.	PUNCT
biomedich-205	77	1	inhibitor	inhibitor	NOUN
biomedich-205	77	2	selection	selection	NOUN
biomedich-205	77	3	was	be	AUX
biomedich-205	77	4	based	base	VERB
biomedich-205	77	5	on	on	ADP
biomedich-205	77	6	intracting	intracte	VERB
biomedich-205	77	7	energy	energy	NOUN
biomedich-205	77	8	and	and	CCONJ
biomedich-205	77	9	structural	structural	ADJ
biomedich-205	77	10	comparison	comparison	NOUN
biomedich-205	77	11	(	(	PUNCT
biomedich-205	77	12	table	table	NOUN
biomedich-205	77	13	1	1	NUM
biomedich-205	77	14	)	)	PUNCT
biomedich-205	77	15	.	.	PUNCT
biomedich-205	78	1	pharmacophore	pharmacophore	NOUN
biomedich-205	78	2	designing	designing	NOUN
biomedich-205	78	3	/	/	SYM
biomedich-205	78	4	modeling	model	VERB
biomedich-205	78	5	the	the	DET
biomedich-205	78	6	pharmacophore	pharmacophore	NOUN
biomedich-205	78	7	was	be	AUX
biomedich-205	78	8	designed	design	VERB
biomedich-205	78	9	using	use	VERB
biomedich-205	78	10	pharmagist	pharmagist	NOUN
biomedich-205	78	11	(	(	PUNCT
biomedich-205	78	12	laskowski	laskowski	VERB
biomedich-205	78	13	et	et	PROPN
biomedich-205	78	14	al	al	PROPN
biomedich-205	78	15	.	.	PROPN
biomedich-205	78	16	,	,	PUNCT
biomedich-205	78	17	2018	2018	NUM
biomedich-205	78	18	)	)	PUNCT
biomedich-205	78	19	,	,	PUNCT
biomedich-205	78	20	and	and	CCONJ
biomedich-205	78	21	the	the	DET
biomedich-205	78	22	pharmacophore	pharmacophore	NOUN
biomedich-205	78	23	was	be	AUX
biomedich-205	78	24	selected	select	VERB
biomedich-205	78	25	predicted	predict	VERB
biomedich-205	78	26	on	on	ADP
biomedich-205	78	27	its	its	PRON
biomedich-205	78	28	high	high	ADJ
biomedich-205	78	29	range	range	NOUN
biomedich-205	78	30	and	and	CCONJ
biomedich-205	78	31	the	the	DET
biomedich-205	78	32	number	number	NOUN
biomedich-205	78	33	of	of	ADP
biomedich-205	78	34	molecules	molecule	NOUN
biomedich-205	78	35	placed	place	VERB
biomedich-205	78	36	in	in	ADP
biomedich-205	78	37	the	the	DET
biomedich-205	78	38	design	design	NOUN
biomedich-205	78	39	.	.	PUNCT
biomedich-205	79	1	pharmacophores	pharmacophore	NOUN
biomedich-205	79	2	are	be	AUX
biomedich-205	79	3	a	a	DET
biomedich-205	79	4	three	three	NUM
biomedich-205	79	5	-	-	PUNCT
biomedich-205	79	6	dimensional	dimensional	ADJ
biomedich-205	79	7	sequence	sequence	NOUN
biomedich-205	79	8	of	of	ADP
biomedich-205	79	9	properties	property	NOUN
biomedich-205	79	10	(	(	PUNCT
biomedich-205	79	11	chemical	chemical	NOUN
biomedich-205	79	12	bond	bond	NOUN
biomedich-205	79	13	donors	donor	NOUN
biomedich-205	79	14	,	,	PUNCT
biomedich-205	79	15	chemical	chemical	NOUN
biomedich-205	79	16	bond	bond	NOUN
biomedich-205	79	17	acceptors	acceptor	NOUN
biomedich-205	79	18	,	,	PUNCT
biomedich-205	79	19	anions	anion	NOUN
biomedich-205	79	20	/	/	SYM
biomedich-205	79	21	cations	cation	NOUN
biomedich-205	79	22	,	,	PUNCT
biomedich-205	79	23	aromatic	aromatic	ADJ
biomedich-205	79	24	rings	ring	NOUN
biomedich-205	79	25	,	,	PUNCT
biomedich-205	79	26	hydro	hydro	NOUN
biomedich-205	79	27	-	-	PUNCT
biomedich-205	79	28	phobic	phobic	ADJ
biomedich-205	79	29	groups	group	NOUN
biomedich-205	79	30	)	)	PUNCT
biomedich-205	79	31	required	require	VERB
biomedich-205	79	32	for	for	ADP
biomedich-205	79	33	a	a	DET
biomedich-205	79	34	ligand	ligand	NOUN
biomedich-205	79	35	to	to	PART
biomedich-205	79	36	communicate	communicate	VERB
biomedich-205	79	37	with	with	ADP
biomedich-205	79	38	a	a	DET
biomedich-205	79	39	particular	particular	ADJ
biomedich-205	79	40	target	target	NOUN
biomedich-205	79	41	(	(	PUNCT
biomedich-205	79	42	schneidman	schneidman	NOUN
biomedich-205	79	43	-	-	PUNCT
biomedich-205	79	44	duhovny	duhovny	NOUN
biomedich-205	79	45	et	et	PROPN
biomedich-205	79	46	al	al	PROPN
biomedich-205	79	47	.	.	PROPN
biomedich-205	79	48	,	,	PUNCT
biomedich-205	79	49	2008	2008	NUM
biomedich-205	79	50	)	)	PUNCT
biomedich-205	79	51	.	.	PUNCT
biomedich-205	80	1	screening	screen	VERB
biomedich-205	80	2	virtually	virtually	ADV
biomedich-205	80	3	for	for	ADP
biomedich-205	80	4	the	the	DET
biomedich-205	80	5	pharmacophore	pharmacophore	NOUN
biomedich-205	80	6	prior	prior	ADV
biomedich-205	80	7	to	to	ADP
biomedich-205	80	8	wet	wet	ADJ
biomedich-205	80	9	-	-	PUNCT
biomedich-205	80	10	lab	lab	NOUN
biomedich-205	80	11	investigations	investigation	NOUN
biomedich-205	80	12	,	,	PUNCT
biomedich-205	80	13	one	one	NUM
biomedich-205	80	14	of	of	ADP
biomedich-205	80	15	the	the	DET
biomedich-205	80	16	fundamental	fundamental	ADJ
biomedich-205	80	17	levels	level	NOUN
biomedich-205	80	18	in	in	ADP
biomedich-205	80	19	drug	drug	NOUN
biomedich-205	80	20	improvement	improvement	NOUN
biomedich-205	80	21	is	be	AUX
biomedich-205	80	22	digital	digital	ADJ
biomedich-205	80	23	screening	screening	NOUN
biomedich-205	80	24	.	.	PUNCT
biomedich-205	81	1	this	this	DET
biomedich-205	81	2	manner	manner	NOUN
biomedich-205	81	3	consists	consist	VERB
biomedich-205	81	4	of	of	ADP
biomedich-205	81	5	estimating	estimate	VERB
biomedich-205	81	6	the	the	DET
biomedich-205	81	7	binding	bind	VERB
biomedich-205	81	8	affinity	affinity	NOUN
biomedich-205	81	9	of	of	ADP
biomedich-205	81	10	a	a	DET
biomedich-205	81	11	capability	capability	NOUN
biomedich-205	81	12	medicine	medicine	NOUN
biomedich-205	81	13	candidate	candidate	NOUN
biomedich-205	81	14	to	to	ADP
biomedich-205	81	15	a	a	DET
biomedich-205	81	16	goal	goal	NOUN
biomedich-205	81	17	protein	protein	NOUN
biomedich-205	81	18	.	.	PUNCT
biomedich-205	82	1	virtual	virtual	ADJ
biomedich-205	82	2	screening	screening	NOUN
biomedich-205	82	3	is	be	AUX
biomedich-205	82	4	likewise	likewise	ADV
biomedich-205	82	5	utilised	utilise	VERB
biomedich-205	82	6	to	to	PART
biomedich-205	82	7	evaluate	evaluate	VERB
biomedich-205	82	8	capability	capability	NOUN
biomedich-205	82	9	binding	bind	VERB
biomedich-205	82	10	modalities	modality	NOUN
biomedich-205	82	11	of	of	ADP
biomedich-205	82	12	the	the	DET
biomedich-205	82	13	medicinal	medicinal	ADJ
biomedich-205	82	14	candidate	candidate	NOUN
biomedich-205	82	15	and	and	CCONJ
biomedich-205	82	16	different	different	ADJ
biomedich-205	82	17	drug	drug	NOUN
biomedich-205	82	18	-	-	PUNCT
biomedich-205	82	19	like	like	ADJ
biomedich-205	82	20	short	short	ADJ
biomedich-205	82	21	molecules	molecule	NOUN
biomedich-205	82	22	throughout	throughout	ADP
biomedich-205	82	23	interplay	interplay	NOUN
biomedich-205	82	24	with	with	ADP
biomedich-205	82	25	the	the	DET
biomedich-205	82	26	goal	goal	NOUN
biomedich-205	82	27	protein	protein	NOUN
biomedich-205	82	28	.	.	PUNCT
biomedich-205	83	1	using	use	VERB
biomedich-205	83	2	hpc	hpc	NOUN
biomedich-205	83	3	“	"	PUNCT
biomedich-205	83	4	high	high	ADJ
biomedich-205	83	5	-	-	PUNCT
biomedich-205	83	6	performance	performance	NOUN
biomedich-205	83	7	computing	computing	NOUN
biomedich-205	83	8	”	"	PUNCT
biomedich-205	83	9	configuration	configuration	NOUN
biomedich-205	83	10	technologies	technology	NOUN
biomedich-205	83	11	(	(	PUNCT
biomedich-205	83	12	jaghoori	jaghoori	NOUN
biomedich-205	83	13	et	et	PROPN
biomedich-205	83	14	al	al	PROPN
biomedich-205	83	15	.	.	PROPN
biomedich-205	83	16	,	,	PUNCT
biomedich-205	83	17	2016	2016	NUM
biomedich-205	83	18	)	)	PUNCT
biomedich-205	83	19	,	,	PUNCT
biomedich-205	83	20	the	the	DET
biomedich-205	83	21	maximum	maximum	ADJ
biomedich-205	83	22	distinguished	distinguished	ADJ
biomedich-205	83	23	medicine	medicine	NOUN
biomedich-205	83	24	applicants	applicant	NOUN
biomedich-205	83	25	displaying	display	VERB
biomedich-205	83	26	capability	capability	NOUN
biomedich-205	83	27	binding	bind	VERB
biomedich-205	83	28	affinity	affinity	NOUN
biomedich-205	83	29	in	in	ADP
biomedich-205	83	30	the	the	DET
biomedich-205	83	31	direction	direction	NOUN
biomedich-205	83	32	of	of	ADP
biomedich-205	83	33	the	the	DET
biomedich-205	83	34	goal	goal	NOUN
biomedich-205	83	35	protein	protein	NOUN
biomedich-205	83	36	can	can	AUX
biomedich-205	83	37	be	be	AUX
biomedich-205	83	38	eliminated	eliminate	VERB
biomedich-205	83	39	.	.	PUNCT
biomedich-205	84	1	through	through	ADP
biomedich-205	84	2	the	the	DET
biomedich-205	84	3	virtual	virtual	ADJ
biomedich-205	84	4	screening	screening	NOUN
biomedich-205	84	5	manner	manner	NOUN
biomedich-205	84	6	,	,	PUNCT
biomedich-205	84	7	numerous	numerous	ADJ
biomedich-205	84	8	bioactive	bioactive	ADJ
biomedich-205	84	9	compounds	compound	NOUN
biomedich-205	84	10	that	that	PRON
biomedich-205	84	11	could	could	AUX
biomedich-205	84	12	have	have	VERB
biomedich-205	84	13	interaction	interaction	NOUN
biomedich-205	84	14	with	with	ADP
biomedich-205	84	15	the	the	DET
biomedich-205	84	16	goal	goal	NOUN
biomedich-205	84	17	protein	protein	NOUN
biomedich-205	84	18	can	can	AUX
biomedich-205	84	19	be	be	AUX
biomedich-205	84	20	found	find	VERB
biomedich-205	84	21	(	(	PUNCT
biomedich-205	84	22	langer	langer	PROPN
biomedich-205	84	23	&	&	CCONJ
biomedich-205	84	24	hoffmann	hoffmann	PROPN
biomedich-205	84	25	,	,	PUNCT
biomedich-205	84	26	2008	2008	NUM
biomedich-205	84	27	)	)	PUNCT
biomedich-205	84	28	.	.	PUNCT
biomedich-205	85	1	the	the	DET
biomedich-205	85	2	pharmacophore	pharmacophore	NOUN
biomedich-205	85	3	become	become	VERB
biomedich-205	85	4	absolutely	absolutely	ADV
biomedich-205	85	5	screened	screen	VERB
biomedich-205	85	6	towards	towards	ADP
biomedich-205	85	7	the	the	DET
biomedich-205	85	8	zinc	zinc	NOUN
biomedich-205	85	9	drug	drug	NOUN
biomedich-205	85	10	database	database	NOUN
biomedich-205	85	11	the	the	DET
biomedich-205	85	12	use	use	NOUN
biomedich-205	85	13	of	of	ADP
biomedich-205	85	14	zincpharmer	zincpharmer	NOUN
biomedich-205	85	15	(	(	PUNCT
biomedich-205	85	16	koes	koe	NOUN
biomedich-205	85	17	&	&	CCONJ
biomedich-205	85	18	camacho	camacho	PROPN
biomedich-205	85	19	,	,	PUNCT
biomedich-205	85	20	2012	2012	NUM
biomedich-205	85	21	)	)	PUNCT
biomedich-205	85	22	,	,	PUNCT
biomedich-205	85	23	and	and	CCONJ
biomedich-205	85	24	1033	1033	NUM
biomedich-205	85	25	hits/	hits/	NOUN
biomedich-205	85	26	compounds	compound	NOUN
biomedich-205	85	27	have	have	AUX
biomedich-205	85	28	been	be	AUX
biomedich-205	85	29	identified	identify	VERB
biomedich-205	85	30	.	.	PUNCT
biomedich-205	86	1	molecular	molecular	ADJ
biomedich-205	86	2	docking	docking	NOUN
biomedich-205	86	3	for	for	ADP
biomedich-205	86	4	the	the	DET
biomedich-205	86	5	last	last	ADJ
biomedich-205	86	6	molecules	molecule	NOUN
biomedich-205	86	7	screened	screen	VERB
biomedich-205	86	8	sdf	sdf	NOUN
biomedich-205	86	9	-	-	PUNCT
biomedich-205	86	10	formatted	format	VERB
biomedich-205	86	11	structures	structure	NOUN
biomedich-205	86	12	(	(	PUNCT
biomedich-205	86	13	each	each	DET
biomedich-205	86	14	molecule	molecule	NOUN
biomedich-205	86	15	in	in	ADP
biomedich-205	86	16	a	a	DET
biomedich-205	86	17	single	single	ADJ
biomedich-205	86	18	file	file	NOUN
biomedich-205	86	19	)	)	PUNCT
biomedich-205	86	20	were	be	AUX
biomedich-205	86	21	obtained	obtain	VERB
biomedich-205	86	22	and	and	CCONJ
biomedich-205	86	23	used	use	VERB
biomedich-205	86	24	to	to	PART
biomedich-205	86	25	dock	dock	VERB
biomedich-205	86	26	the	the	DET
biomedich-205	86	27	terminal	terminal	NOUN
biomedich-205	86	28	of	of	ADP
biomedich-205	86	29	screened	screen	VERB
biomedich-205	86	30	1033	1033	NUM
biomedich-205	86	31	compounds	compound	NOUN
biomedich-205	86	32	(	(	PUNCT
biomedich-205	86	33	using	use	VERB
biomedich-205	86	34	the	the	DET
biomedich-205	86	35	desired	desire	VERB
biomedich-205	86	36	pharmacophore	pharmacophore	NOUN
biomedich-205	86	37	)	)	PUNCT
biomedich-205	86	38	.	.	PUNCT
biomedich-205	87	1	i	i	PRON
biomedich-205	87	2	used	use	VERB
biomedich-205	87	3	a	a	DET
biomedich-205	87	4	python	python	NOUN
biomedich-205	87	5	script	script	NOUN
biomedich-205	87	6	to	to	AUX
biomedich-205	87	7	separate	separate	VERB
biomedich-205	87	8	and	and	CCONJ
biomedich-205	87	9	reduce	reduce	VERB
biomedich-205	87	10	the	the	DET
biomedich-205	87	11	energy	energy	NOUN
biomedich-205	87	12	of	of	ADP
biomedich-205	87	13	these	these	DET
biomedich-205	87	14	structures	structure	NOUN
biomedich-205	87	15	.	.	PUNCT
biomedich-205	88	1	the	the	DET
biomedich-205	88	2	resulting	result	VERB
biomedich-205	88	3	structure	structure	NOUN
biomedich-205	88	4	was	be	AUX
biomedich-205	88	5	changed	change	VERB
biomedich-205	88	6	to	to	ADP
biomedich-205	88	7	pdbqt	pdbqt	ADJ
biomedich-205	88	8	format	format	NOUN
biomedich-205	88	9	using	use	VERB
biomedich-205	88	10	vina	vina	NOUN
biomedich-205	88	11	to	to	PART
biomedich-205	88	12	dock	dock	VERB
biomedich-205	88	13	to	to	ADP
biomedich-205	88	14	the	the	DET
biomedich-205	88	15	required	require	VERB
biomedich-205	88	16	protein	protein	NOUN
biomedich-205	88	17	.	.	PUNCT
biomedich-205	89	1	all	all	DET
biomedich-205	89	2	compounds	compound	NOUN
biomedich-205	89	3	were	be	AUX
biomedich-205	89	4	docked	dock	VERB
biomedich-205	89	5	to	to	ADP
biomedich-205	89	6	autodock	autodock	NOUN
biomedich-205	89	7	vina	vina	PROPN
biomedich-205	89	8	(	(	PUNCT
biomedich-205	89	9	guidi	guidi	PROPN
biomedich-205	89	10	et	et	PROPN
biomedich-205	89	11	al	al	PROPN
biomedich-205	89	12	.	.	PROPN
biomedich-205	89	13	,	,	PUNCT
biomedich-205	89	14	2006	2006	NUM
biomedich-205	89	15	)	)	PUNCT
biomedich-205	89	16	and	and	CCONJ
biomedich-205	89	17	the	the	DET
biomedich-205	89	18	top	top	ADJ
biomedich-205	89	19	results	result	NOUN
biomedich-205	89	20	(	(	PUNCT
biomedich-205	89	21	contingent	contingent	NOUN
biomedich-205	89	22	on	on	ADP
biomedich-205	89	23	interaction	interaction	NOUN
biomedich-205	89	24	and	and	CCONJ
biomedich-205	89	25	affinity	affinity	NOUN
biomedich-205	89	26	energy	energy	NOUN
biomedich-205	89	27	)	)	PUNCT
biomedich-205	89	28	were	be	AUX
biomedich-205	89	29	examined	examine	VERB
biomedich-205	89	30	using	use	VERB
biomedich-205	89	31	autodock	autodock	NOUN
biomedich-205	89	32	tools	tool	NOUN
biomedich-205	89	33	(	(	PUNCT
biomedich-205	89	34	hanwell	hanwell	PROPN
biomedich-205	89	35	et	et	PROPN
biomedich-205	89	36	al	al	PROPN
biomedich-205	89	37	.	.	PROPN
biomedich-205	89	38	,	,	PUNCT
biomedich-205	89	39	2012	2012	NUM
biomedich-205	89	40	)	)	PUNCT
biomedich-205	89	41	.	.	PUNCT
biomedich-205	90	1	the	the	DET
biomedich-205	90	2	docking	dock	VERB
biomedich-205	90	3	grids	grid	NOUN
biomedich-205	90	4	coordinates	coordinate	NOUN
biomedich-205	90	5	were	be	AUX
biomedich-205	90	6	40.516000	40.516000	NUM
biomedich-205	90	7	(	(	PUNCT
biomedich-205	90	8	x	x	NOUN
biomedich-205	90	9	)	)	PUNCT
biomedich-205	90	10	,	,	PUNCT
biomedich-205	90	11	24.375625	24.375625	NUM
biomedich-205	90	12	(	(	PUNCT
biomedich-205	90	13	y	y	NOUN
biomedich-205	90	14	)	)	PUNCT
biomedich-205	90	15	,	,	PUNCT
biomedich-205	90	16	and	and	CCONJ
biomedich-205	90	17	25.098375	25.098375	NUM
biomedich-205	90	18	(	(	PUNCT
biomedich-205	90	19	z	z	NOUN
biomedich-205	90	20	)	)	PUNCT
biomedich-205	90	21	,	,	PUNCT
biomedich-205	90	22	and	and	CCONJ
biomedich-205	90	23	each	each	DET
biomedich-205	90	24	grid	grid	NOUN
biomedich-205	90	25	had	have	VERB
biomedich-205	90	26	dimensions	dimension	NOUN
biomedich-205	90	27	of	of	ADP
biomedich-205	90	28	25	25	NUM
biomedich-205	90	29	.	.	PUNCT
biomedich-205	91	1	there	there	PRON
biomedich-205	91	2	were	be	VERB
biomedich-205	91	3	20	20	NUM
biomedich-205	91	4	modes	mode	NOUN
biomedich-205	91	5	in	in	ADP
biomedich-205	91	6	all	all	PRON
biomedich-205	91	7	.	.	PUNCT
biomedich-205	92	1	table	table	NOUN
biomedich-205	92	2	2	2	NUM
biomedich-205	92	3	shows	show	VERB
biomedich-205	92	4	the	the	DET
biomedich-205	92	5	10	10	NUM
biomedich-205	92	6	most	most	ADV
biomedich-205	92	7	important	important	ADJ
biomedich-205	92	8	zinc	zinc	NOUN
biomedich-205	92	9	molecules	molecule	NOUN
biomedich-205	92	10	selected	select	VERB
biomedich-205	92	11	as	as	ADP
biomedich-205	92	12	potential	potential	ADJ
biomedich-205	92	13	treatment	treatment	NOUN
biomedich-205	92	14	candidates	candidate	NOUN
biomedich-205	92	15	.	.	PUNCT
biomedich-205	93	1	122	122	NUM
biomedich-205	93	2	biology	biology	NOUN
biomedich-205	93	3	,	,	PUNCT
biomedich-205	93	4	medicine	medicine	NOUN
biomedich-205	93	5	,	,	PUNCT
biomedich-205	93	6	&	&	CCONJ
biomedich-205	93	7	natural	natural	ADJ
biomedich-205	93	8	product	product	NOUN
biomedich-205	93	9	chemistry	chemistry	NOUN
biomedich-205	93	10	11	11	NUM
biomedich-205	93	11	(	(	PUNCT
biomedich-205	93	12	2	2	NUM
biomedich-205	93	13	)	)	PUNCT
biomedich-205	93	14	,	,	PUNCT
biomedich-205	93	15	2022	2022	NUM
biomedich-205	93	16	:	:	PUNCT
biomedich-205	93	17	119	119	NUM
biomedich-205	93	18	-	-	SYM
biomedich-205	93	19	131	131	NUM
biomedich-205	93	20	table	table	NOUN
biomedich-205	93	21	2	2	NUM
biomedich-205	93	22	.	.	PUNCT
biomedich-205	93	23	amino	amino	NOUN
biomedich-205	93	24	acid	acid	NOUN
biomedich-205	93	25	interactions	interaction	NOUN
biomedich-205	93	26	of	of	ADP
biomedich-205	93	27	molecules	molecule	NOUN
biomedich-205	93	28	.	.	PUNCT
biomedich-205	94	1	molecule	molecule	NOUN
biomedich-205	94	2	name	name	NOUN
biomedich-205	94	3	binding	bind	VERB
biomedich-205	94	4	energy	energy	NOUN
biomedich-205	94	5	number	number	NOUN
biomedich-205	94	6	of	of	ADP
biomedich-205	94	7	interactions	interaction	NOUN
biomedich-205	94	8	amino	amino	NOUN
biomedich-205	94	9	acid	acid	NOUN
biomedich-205	94	10	interaction	interaction	NOUN
biomedich-205	94	11	apomorphine	apomorphine	NOUN
biomedich-205	94	12	-10.8	-10.8	ADP
biomedich-205	94	13	7	7	NUM
biomedich-205	94	14	arg	arg	NOUN
biomedich-205	94	15	458	458	NUM
biomedich-205	94	16	,	,	PUNCT
biomedich-205	94	17	pro	pro	X
biomedich-205	94	18	438	438	NUM
biomedich-205	94	19	,	,	PUNCT
biomedich-205	94	20	arg	arg	NOUN
biomedich-205	94	21	357	357	NUM
biomedich-205	94	22	,	,	PUNCT
biomedich-205	94	23	trp	trp	PROPN
biomedich-205	94	24	461	461	NUM
biomedich-205	94	25	and	and	CCONJ
biomedich-205	94	26	val	val	NOUN
biomedich-205	94	27	460	460	NUM
biomedich-205	94	28	oxyphencyclimine	oxyphencyclimine	NOUN
biomedich-205	94	29	-10	-10	PUNCT
biomedich-205	94	30	8	8	NUM
biomedich-205	94	31	cys	cys	PROPN
biomedich-205	94	32	358	358	NUM
biomedich-205	94	33	,	,	PUNCT
biomedich-205	94	34	pro	pro	X
biomedich-205	94	35	331	331	NUM
biomedich-205	94	36	,	,	PUNCT
biomedich-205	94	37	ala	ala	PROPN
biomedich-205	94	38	478	478	NUM
biomedich-205	94	39	,	,	PUNCT
biomedich-205	94	40	val	val	NOUN
biomedich-205	94	41	460	460	NUM
biomedich-205	94	42	,	,	PUNCT
biomedich-205	94	43	arg	arg	NOUN
biomedich-205	94	44	458	458	NUM
biomedich-205	94	45	,	,	PUNCT
biomedich-205	94	46	val	val	NOUN
biomedich-205	94	47	359	359	NUM
biomedich-205	94	48	,	,	PUNCT
biomedich-205	94	49	thu	thu	PROPN
biomedich-205	94	50	459	459	NUM
biomedich-205	94	51	and	and	CCONJ
biomedich-205	94	52	pro	pro	ADJ
biomedich-205	94	53	438	438	NUM
biomedich-205	94	54	canadine	canadine	NOUN
biomedich-205	94	55	-10	-10	PUNCT
biomedich-205	94	56	7	7	NUM
biomedich-205	94	57	arg	arg	NOUN
biomedich-205	94	58	357	357	NUM
biomedich-205	94	59	,	,	PUNCT
biomedich-205	94	60	asp	asp	PROPN
biomedich-205	94	61	360	360	NUM
biomedich-205	94	62	,	,	PUNCT
biomedich-205	94	63	pro	pro	X
biomedich-205	94	64	331	331	NUM
biomedich-205	94	65	,	,	PUNCT
biomedich-205	94	66	ala	ala	PROPN
biomedich-205	94	67	478	478	NUM
biomedich-205	94	68	,	,	PUNCT
biomedich-205	94	69	val	val	NOUN
biomedich-205	94	70	460	460	NUM
biomedich-205	94	71	and	and	CCONJ
biomedich-205	94	72	pro	pro	ADJ
biomedich-205	94	73	438	438	NUM
biomedich-205	94	74	naltrexone	naltrexone	PROPN
biomedich-205	94	75	-9.8	-9.8	PROPN
biomedich-205	94	76	10	10	NUM
biomedich-205	94	77	arg	arg	NOUN
biomedich-205	94	78	476	476	NUM
biomedich-205	94	79	,	,	PUNCT
biomedich-205	94	80	arg	arg	VERB
biomedich-205	94	81	458	458	NUM
biomedich-205	94	82	,	,	PUNCT
biomedich-205	94	83	val	val	NOUN
biomedich-205	94	84	460	460	NUM
biomedich-205	94	85	,	,	PUNCT
biomedich-205	94	86	pro	pro	X
biomedich-205	94	87	331	331	NUM
biomedich-205	94	88	,	,	PUNCT
biomedich-205	94	89	ala	ala	PROPN
biomedich-205	94	90	330	330	NUM
biomedich-205	94	91	,	,	PUNCT
biomedich-205	94	92	thr	thr	PROPN
biomedich-205	94	93	335	335	NUM
biomedich-205	94	94	,	,	PUNCT
biomedich-205	94	95	ala	ala	PROPN
biomedich-205	94	96	328	328	NUM
biomedich-205	94	97	and	and	CCONJ
biomedich-205	94	98	cys	cys	PROPN
biomedich-205	94	99	358	358	NUM
biomedich-205	94	100	oxolinic	oxolinic	ADJ
biomedich-205	94	101	-9.6	-9.6	PROPN
biomedich-205	94	102	7	7	NUM
biomedich-205	94	103	leu	leu	PROPN
biomedich-205	94	104	440	440	NUM
biomedich-205	94	105	,	,	PUNCT
biomedich-205	94	106	pro	pro	X
biomedich-205	94	107	438	438	NUM
biomedich-205	94	108	,	,	PUNCT
biomedich-205	94	109	trp	trp	PROPN
biomedich-205	94	110	461	461	NUM
biomedich-205	94	111	,	,	PUNCT
biomedich-205	94	112	val	val	NOUN
biomedich-205	94	113	650	650	NUM
biomedich-205	94	114	,	,	PUNCT
biomedich-205	94	115	thr	thr	PROPN
biomedich-205	94	116	437	437	NUM
biomedich-205	94	117	and	and	CCONJ
biomedich-205	94	118	thr	thr	PROPN
biomedich-205	94	119	459	459	NUM
biomedich-205	94	120	norfloxacin	norfloxacin	NOUN
biomedich-205	95	1	-9.6	-9.6	ADV
biomedich-205	95	2	9	9	NUM
biomedich-205	95	3	trp	trp	PROPN
biomedich-205	95	4	461	461	NUM
biomedich-205	95	5	,	,	PUNCT
biomedich-205	95	6	leu	leu	PROPN
biomedich-205	95	7	436	436	NUM
biomedich-205	95	8	,	,	PUNCT
biomedich-205	95	9	ile	ile	PROPN
biomedich-205	95	10	416	416	NUM
biomedich-205	95	11	,	,	PUNCT
biomedich-205	95	12	ala	ala	PROPN
biomedich-205	95	13	649	649	NUM
biomedich-205	95	14	,	,	PUNCT
biomedich-205	95	15	pro	pro	X
biomedich-205	95	16	438	438	NUM
biomedich-205	95	17	,	,	PUNCT
biomedich-205	95	18	arg	arg	VERB
biomedich-205	95	19	458	458	NUM
biomedich-205	95	20	,	,	PUNCT
biomedich-205	95	21	arg	arg	VERB
biomedich-205	95	22	357	357	NUM
biomedich-205	95	23	and	and	CCONJ
biomedich-205	95	24	arg	arg	VERB
biomedich-205	95	25	412	412	NUM
biomedich-205	95	26	canadine	canadine	NOUN
biomedich-205	95	27	-9.6	-9.6	ADP
biomedich-205	95	28	7	7	NUM
biomedich-205	95	29	arg	arg	NOUN
biomedich-205	95	30	458	458	NUM
biomedich-205	95	31	,	,	PUNCT
biomedich-205	95	32	asp	asp	PROPN
biomedich-205	95	33	360	360	NUM
biomedich-205	95	34	,	,	PUNCT
biomedich-205	95	35	pro	pro	X
biomedich-205	95	36	438	438	NUM
biomedich-205	95	37	,	,	PUNCT
biomedich-205	95	38	ile	ile	PROPN
biomedich-205	95	39	416	416	NUM
biomedich-205	95	40	,	,	PUNCT
biomedich-205	95	41	leu	leu	PROPN
biomedich-205	95	42	440	440	NUM
biomedich-205	95	43	,	,	PUNCT
biomedich-205	95	44	thr	thr	PROPN
biomedich-205	95	45	459	459	NUM
biomedich-205	95	46	,	,	PUNCT
biomedich-205	95	47	val	val	NOUN
biomedich-205	95	48	460	460	NUM
biomedich-205	95	49	and	and	CCONJ
biomedich-205	95	50	arg	arg	VERB
biomedich-205	95	51	357	357	NUM
biomedich-205	95	52	hesperetin	hesperetin	NOUN
biomedich-205	95	53	-9.4	-9.4	NOUN
biomedich-205	95	54	9	9	NUM
biomedich-205	95	55	arg	arg	NOUN
biomedich-205	95	56	412	412	NUM
biomedich-205	95	57	,	,	PUNCT
biomedich-205	95	58	ala	ala	PROPN
biomedich-205	95	59	330	330	NUM
biomedich-205	95	60	,	,	PUNCT
biomedich-205	95	61	arg	arg	NOUN
biomedich-205	95	62	357	357	NUM
biomedich-205	95	63	,	,	PUNCT
biomedich-205	95	64	cys	cys	PROPN
biomedich-205	95	65	358	358	NUM
biomedich-205	95	66	,	,	PUNCT
biomedich-205	95	67	pro	pro	X
biomedich-205	95	68	331	331	NUM
biomedich-205	95	69	,	,	PUNCT
biomedich-205	95	70	trp	trp	PROPN
biomedich-205	95	71	461	461	NUM
biomedich-205	95	72	,	,	PUNCT
biomedich-205	95	73	thr	thr	PROPN
biomedich-205	95	74	459	459	NUM
biomedich-205	96	1	and	and	CCONJ
biomedich-205	96	2	val	val	NOUN
biomedich-205	96	3	460	460	NUM
biomedich-205	96	4	labetalol	labetalol	NOUN
biomedich-205	96	5	-9.3	-9.3	NOUN
biomedich-205	96	6	9	9	NUM
biomedich-205	96	7	trp	trp	PROPN
biomedich-205	96	8	461	461	NUM
biomedich-205	96	9	,	,	PUNCT
biomedich-205	96	10	cys	cys	PROPN
biomedich-205	96	11	358	358	NUM
biomedich-205	96	12	,	,	PUNCT
biomedich-205	96	13	thr	thr	PROPN
biomedich-205	96	14	437	437	NUM
biomedich-205	96	15	,	,	PUNCT
biomedich-205	96	16	pro	pro	X
biomedich-205	96	17	438	438	NUM
biomedich-205	96	18	,	,	PUNCT
biomedich-205	96	19	val	val	NOUN
biomedich-205	96	20	650	650	NUM
biomedich-205	96	21	and	and	CCONJ
biomedich-205	96	22	asp	asp	PROPN
biomedich-205	96	23	651	651	NUM
biomedich-205	96	24	benorilate	benorilate	NOUN
biomedich-205	96	25	-9.2	-9.2	PROPN
biomedich-205	96	26	6	6	NUM
biomedich-205	96	27	arg	arg	NOUN
biomedich-205	96	28	458	458	NUM
biomedich-205	96	29	,	,	PUNCT
biomedich-205	96	30	val	val	NOUN
biomedich-205	96	31	460	460	NUM
biomedich-205	96	32	,	,	PUNCT
biomedich-205	96	33	arg	arg	NOUN
biomedich-205	96	34	357	357	NUM
biomedich-205	96	35	,	,	PUNCT
biomedich-205	96	36	pro	pro	X
biomedich-205	96	37	438	438	NUM
biomedich-205	96	38	and	and	CCONJ
biomedich-205	96	39	leu	leu	PROPN
biomedich-205	96	40	436	436	NUM
biomedich-205	96	41	(	(	PUNCT
biomedich-205	96	42	table	table	NOUN
biomedich-205	96	43	2	2	NUM
biomedich-205	96	44	)	)	PUNCT
biomedich-205	96	45	the	the	DET
biomedich-205	96	46	binding	bind	VERB
biomedich-205	96	47	energy	energy	NOUN
biomedich-205	96	48	of	of	ADP
biomedich-205	96	49	top	top	ADJ
biomedich-205	96	50	ten	ten	NUM
biomedich-205	96	51	molecules	molecule	NOUN
biomedich-205	96	52	are	be	AUX
biomedich-205	96	53	shown	show	VERB
biomedich-205	96	54	with	with	ADP
biomedich-205	96	55	their	their	PRON
biomedich-205	96	56	amino	amino	NOUN
biomedich-205	96	57	acid	acid	NOUN
biomedich-205	96	58	interactions	interaction	NOUN
biomedich-205	96	59	.	.	PUNCT
biomedich-205	97	1	final	final	ADJ
biomedich-205	97	2	medication	medication	NOUN
biomedich-205	97	3	candidates	candidate	NOUN
biomedich-205	97	4	'	'	PART
biomedich-205	97	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-205	97	6	characteristics	characteristic	NOUN
biomedich-205	97	7	we	we	PRON
biomedich-205	97	8	used	use	VERB
biomedich-205	97	9	openbabel	openbabel	NOUN
biomedich-205	97	10	(	(	PUNCT
biomedich-205	97	11	http://openbabel.org/wiki/main	http://openbabel.org/wiki/main	NOUN
biomedich-205	97	12	page	page	NOUN
biomedich-205	97	13	)	)	PUNCT
biomedich-205	97	14	to	to	PART
biomedich-205	97	15	create	create	VERB
biomedich-205	97	16	a	a	DET
biomedich-205	97	17	simplified	simplified	ADJ
biomedich-205	97	18	molecular	molecular	ADJ
biomedich-205	97	19	input	input	NOUN
biomedich-205	97	20	system	system	NOUN
biomedich-205	97	21	&	&	CCONJ
biomedich-205	97	22	#	#	NOUN
biomedich-205	97	23	40	40	NUM
biomedich-205	97	24	;	;	PUNCT
biomedich-205	97	25	smiles	smile	NOUN
biomedich-205	97	26	&	&	CCONJ
biomedich-205	97	27	#	#	NOUN
biomedich-205	97	28	41	41	NUM
biomedich-205	97	29	;	;	PUNCT
biomedich-205	97	30	autodockvina	autodockvina	NOUN
biomedich-205	97	31	for	for	ADP
biomedich-205	97	32	the	the	DET
biomedich-205	97	33	top	top	ADJ
biomedich-205	97	34	10	10	NUM
biomedich-205	97	35	compounds	compound	NOUN
biomedich-205	97	36	identified	identify	VERB
biomedich-205	97	37	during	during	ADP
biomedich-205	97	38	virtual	virtual	ADJ
biomedich-205	97	39	screening	screening	NOUN
biomedich-205	97	40	.	.	PUNCT
biomedich-205	98	1	the	the	DET
biomedich-205	98	2	resulting	result	VERB
biomedich-205	98	3	smiles	smile	NOUN
biomedich-205	98	4	code	code	NOUN
biomedich-205	98	5	is	be	AUX
biomedich-205	98	6	zinc	zinc	NOUN
biomedich-205	98	7	(	(	PUNCT
biomedich-205	98	8	sterling	sterling	NOUN
biomedich-205	98	9	&	&	CCONJ
biomedich-205	98	10	irwin	irwin	PROPN
biomedich-205	98	11	,	,	PUNCT
biomedich-205	98	12	2015	2015	NUM
biomedich-205	98	13	)	)	PUNCT
biomedich-205	98	14	,	,	PUNCT
biomedich-205	98	15	molinspiration	molinspiration	NOUN
biomedich-205	98	16	cheminformatics	cheminformatic	NOUN
biomedich-205	98	17	'	'	PART
biomedich-205	98	18	free	free	ADJ
biomedich-205	98	19	online	online	ADJ
biomedich-205	98	20	service	service	NOUN
biomedich-205	98	21	(	(	PUNCT
biomedich-205	98	22	,	,	PUNCT
biomedich-205	98	23	pubchem	pubchem	NOUN
biomedich-205	98	24	.	.	PUNCT
biomedich-205	99	1	analyzed	analyze	VERB
biomedich-205	99	2	using	use	VERB
biomedich-205	99	3	a	a	DET
biomedich-205	99	4	comparison	comparison	NOUN
biomedich-205	99	5	website	website	NOUN
biomedich-205	99	6	.	.	PUNCT
biomedich-205	100	1	,	,	PUNCT
biomedich-205	100	2	swiss	swiss	ADJ
biomedich-205	100	3	adme	adme	NOUN
biomedich-205	100	4	(	(	PUNCT
biomedich-205	100	5	daina	daina	PROPN
biomedich-205	100	6	et	et	PROPN
biomedich-205	100	7	al	al	PROPN
biomedich-205	100	8	.	.	PROPN
biomedich-205	100	9	,	,	PUNCT
biomedich-205	100	10	2017	2017	NUM
biomedich-205	100	11	)	)	PUNCT
biomedich-205	100	12	and	and	CCONJ
biomedich-205	100	13	admet	admet	PROPN
biomedich-205	100	14	sar	sar	PROPN
biomedich-205	100	15	(	(	PUNCT
biomedich-205	100	16	yang	yang	PROPN
biomedich-205	100	17	et	et	PROPN
biomedich-205	100	18	al	al	PROPN
biomedich-205	100	19	.	.	PROPN
biomedich-205	100	20	,	,	PUNCT
biomedich-205	100	21	2019	2019	NUM
biomedich-205	100	22	)	)	PUNCT
biomedich-205	100	23	.	.	PUNCT
biomedich-205	101	1	swissadme	swissadme	NOUN
biomedich-205	101	2	was	be	AUX
biomedich-205	101	3	used	use	VERB
biomedich-205	101	4	to	to	PART
biomedich-205	101	5	calculate	calculate	VERB
biomedich-205	101	6	the	the	DET
biomedich-205	101	7	oral	oral	ADJ
biomedich-205	101	8	bioavailability	bioavailability	NOUN
biomedich-205	101	9	of	of	ADP
biomedich-205	101	10	each	each	DET
biomedich-205	101	11	drug	drug	NOUN
biomedich-205	101	12	(	(	PUNCT
biomedich-205	101	13	table	table	NOUN
biomedich-205	101	14	3	3	NUM
biomedich-205	101	15	)	)	PUNCT
biomedich-205	101	16	.	.	PUNCT
biomedich-205	102	1	for	for	ADP
biomedich-205	102	2	bioactivity	bioactivity	NOUN
biomedich-205	102	3	prediction	prediction	NOUN
biomedich-205	102	4	and	and	CCONJ
biomedich-205	102	5	drug	drug	NOUN
biomedich-205	102	6	similarity	similarity	NOUN
biomedich-205	102	7	from	from	ADP
biomedich-205	102	8	lipinski	lipinski	PROPN
biomedich-205	102	9	's	's	PART
biomedich-205	102	10	rule	rule	NOUN
biomedich-205	102	11	5	5	NUM
biomedich-205	102	12	,	,	PUNCT
biomedich-205	102	13	use	use	VERB
biomedich-205	102	14	the	the	DET
biomedich-205	102	15	predict	predict	ADJ
biomedich-205	102	16	bioactivity	bioactivity	NOUN
biomedich-205	102	17	tool	tool	NOUN
biomedich-205	102	18	available	available	ADJ
biomedich-205	102	19	to	to	PART
biomedich-205	102	20	calculate	calculate	VERB
biomedich-205	102	21	molecular	molecular	ADJ
biomedich-205	102	22	properties	property	NOUN
biomedich-205	102	23	and	and	CCONJ
biomedich-205	102	24	bioactivity	bioactivity	NOUN
biomedich-205	102	25	scores	score	NOUN
biomedich-205	102	26	.	.	PUNCT
biomedich-205	103	1	was	be	AUX
biomedich-205	103	2	evaluated	evaluate	VERB
biomedich-205	103	3	by	by	ADP
biomedich-205	103	4	.	.	PUNCT
biomedich-205	104	1	the	the	DET
biomedich-205	104	2	le	le	PROPN
biomedich-205	104	3	and	and	CCONJ
biomedich-205	104	4	lelp	lelp	ADJ
biomedich-205	104	5	parameters	parameter	NOUN
biomedich-205	104	6	were	be	AUX
biomedich-205	104	7	found	find	VERB
biomedich-205	104	8	from	from	ADP
biomedich-205	104	9	the	the	DET
biomedich-205	104	10	specified	specify	VERB
biomedich-205	104	11	results	result	NOUN
biomedich-205	104	12	.	.	PUNCT
biomedich-205	105	1	table	table	NOUN
biomedich-205	105	2	3	3	NUM
biomedich-205	105	3	.	.	PUNCT
biomedich-205	106	1	bioavailability	bioavailability	NOUN
biomedich-205	106	2	of	of	ADP
biomedich-205	106	3	drugs	drug	NOUN
biomedich-205	106	4	.	.	PUNCT
biomedich-205	107	1	molecule	molecule	NOUN
biomedich-205	107	2	formula	formula	NOUN
biomedich-205	107	3	mw	mw	X
biomedich-205	107	4	ali	ali	PROPN
biomedich-205	107	5	log	log	PROPN
biomedich-205	107	6	s	s	PART
biomedich-205	107	7	bioavailability	bioavailability	NOUN
biomedich-205	107	8	score	score	NOUN
biomedich-205	107	9	synthetic	synthetic	ADJ
biomedich-205	107	10	accessibility	accessibility	NOUN
biomedich-205	107	11	apomorphine	apomorphine	NOUN
biomedich-205	107	12	c17h18no2	c17h18no2	PROPN
biomedich-205	107	13	268.33	268.33	NUM
biomedich-205	107	14	-3.88	-3.88	NUM
biomedich-205	107	15	0.65	0.65	NUM
biomedich-205	107	16	4.29	4.29	NUM
biomedich-205	107	17	oxyphencyclimine	oxyphencyclimine	NOUN
biomedich-205	107	18	c20h28n2o3	c20h28n2o3	PROPN
biomedich-205	108	1	344.45	344.45	NUM
biomedich-205	108	2	-4.89	-4.89	NUM
biomedich-205	108	3	0.65	0.65	NUM
biomedich-205	108	4	5.08	5.08	NUM
biomedich-205	108	5	(	(	PUNCT
biomedich-205	108	6	s)-canadine	s)-canadine	PUNCT
biomedich-205	108	7	)	)	PUNCT
biomedich-205	108	8	c20h22no4	c20h22no4	PROPN
biomedich-205	109	1	340.39	340.39	NUM
biomedich-205	109	2	-4.65	-4.65	ADP
biomedich-205	109	3	0.65	0.65	NUM
biomedich-205	109	4	4.68	4.68	NUM
biomedich-205	109	5	naltrexone	naltrexone	NOUN
biomedich-205	109	6	c20h24no4	c20h24no4	PROPN
biomedich-205	109	7	342.41	342.41	NUM
biomedich-205	109	8	-3.69	-3.69	NOUN
biomedich-205	109	9	0.65	0.65	NUM
biomedich-205	109	10	5.76	5.76	NUM
biomedich-205	109	11	oxolinic	oxolinic	ADJ
biomedich-205	109	12	acid	acid	NOUN
biomedich-205	109	13	c13h11no5	c13h11no5	PROPN
biomedich-205	109	14	261.23	261.23	NUM
biomedich-205	109	15	-3.16	-3.16	NOUN
biomedich-205	109	16	0.66	0.66	NUM
biomedich-205	109	17	3.26	3.26	NUM
biomedich-205	109	18	norfloxacin	norfloxacin	ADP
biomedich-205	109	19	c16h19fn3o3	c16h19fn3o3	NOUN
biomedich-205	109	20	320.34	320.34	NUM
biomedich-205	109	21	-1.14	-1.14	NUM
biomedich-205	109	22	0.65	0.65	NUM
biomedich-205	109	23	1.5	1.5	NUM
biomedich-205	109	24	(	(	PUNCT
biomedich-205	109	25	r)-canadine	r)-canadine	ADP
biomedich-205	109	26	c20h22no4	c20h22no4	PROPN
biomedich-205	109	27	340.39	340.39	NUM
biomedich-205	109	28	-4.65	-4.65	ADP
biomedich-205	109	29	0.65	0.65	NUM
biomedich-205	109	30	4.68	4.68	NUM
biomedich-205	109	31	hesperetin	hesperetin	NOUN
biomedich-205	109	32	c16h14o6	c16h14o6	NOUN
biomedich-205	109	33	302.28	302.28	NUM
biomedich-205	109	34	-5.27	-5.27	NOUN
biomedich-205	109	35	0.65	0.65	NUM
biomedich-205	109	36	4.22	4.22	NUM
biomedich-205	109	37	labetalol	labetalol	NOUN
biomedich-205	109	38	c19h25n2o3	c19h25n2o3	PROPN
biomedich-205	109	39	329.41	329.41	NUM
biomedich-205	109	40	-5.86	-5.86	NUM
biomedich-205	109	41	0.65	0.65	NUM
biomedich-205	109	42	4.04	4.04	NUM
biomedich-205	109	43	benorilate	benorilate	NOUN
biomedich-205	109	44	c17h15no5	c17h15no5	PROPN
biomedich-205	109	45	313.3	313.3	NUM
biomedich-205	109	46	-4.5	-4.5	ADP
biomedich-205	109	47	0.65	0.65	NUM
biomedich-205	109	48	3.16	3.16	NUM
biomedich-205	109	49	(	(	PUNCT
biomedich-205	109	50	table	table	NOUN
biomedich-205	109	51	:	:	PUNCT
biomedich-205	109	52	3	3	X
biomedich-205	109	53	)	)	PUNCT
biomedich-205	109	54	the	the	DET
biomedich-205	109	55	molecular	molecular	ADJ
biomedich-205	109	56	weight	weight	NOUN
biomedich-205	109	57	and	and	CCONJ
biomedich-205	109	58	the	the	DET
biomedich-205	109	59	bioavailability	bioavailability	NOUN
biomedich-205	109	60	value	value	NOUN
biomedich-205	109	61	of	of	ADP
biomedich-205	109	62	various	various	ADJ
biomedich-205	109	63	molecules	molecule	NOUN
biomedich-205	109	64	are	be	AUX
biomedich-205	109	65	given	give	VERB
biomedich-205	109	66	with	with	ADP
biomedich-205	109	67	its	its	PRON
biomedich-205	109	68	synthetic	synthetic	ADJ
biomedich-205	109	69	accessibility	accessibility	NOUN
biomedich-205	109	70	.	.	PUNCT
biomedich-205	110	1	molecular	molecular	ADJ
biomedich-205	110	2	dynamics	dynamic	NOUN
biomedich-205	110	3	of	of	ADP
biomedich-205	110	4	complexes	complex	NOUN
biomedich-205	110	5	of	of	ADP
biomedich-205	110	6	protein	protein	NOUN
biomedich-205	110	7	and	and	CCONJ
biomedich-205	110	8	ligand	ligand	VERB
biomedich-205	110	9	the	the	DET
biomedich-205	110	10	molecular	molecular	ADJ
biomedich-205	110	11	dynamics	dynamic	NOUN
biomedich-205	110	12	of	of	ADP
biomedich-205	110	13	the	the	DET
biomedich-205	110	14	protein	protein	NOUN
biomedich-205	110	15	-	-	PUNCT
biomedich-205	110	16	ligand	ligand	NOUN
biomedich-205	110	17	complex	complex	NOUN
biomedich-205	110	18	was	be	AUX
biomedich-205	110	19	prepared	prepare	VERB
biomedich-205	110	20	and	and	CCONJ
biomedich-205	110	21	calculated	calculate	VERB
biomedich-205	110	22	using	use	VERB
biomedich-205	110	23	gromacs	gromac	NOUN
biomedich-205	110	24	(	(	PUNCT
biomedich-205	110	25	abraham	abraham	PROPN
biomedich-205	110	26	et	et	PROPN
biomedich-205	110	27	al	al	PROPN
biomedich-205	110	28	.	.	PROPN
biomedich-205	110	29	,	,	PUNCT
biomedich-205	110	30	2015	2015	NUM
biomedich-205	110	31	)	)	PUNCT
biomedich-205	110	32	version	version	NOUN
biomedich-205	110	33	2018.4	2018.4	NUM
biomedich-205	110	34	on	on	ADP
biomedich-205	110	35	a	a	DET
biomedich-205	110	36	desktop	desktop	NOUN
biomedich-205	110	37	computer	computer	NOUN
biomedich-205	110	38	with	with	ADP
biomedich-205	110	39	a	a	DET
biomedich-205	110	40	2.80	2.80	NUM
biomedich-205	110	41	ghz	ghz	NOUN
biomedich-205	110	42	and	and	CCONJ
biomedich-205	110	43	nvidia	nvidia	PROPN
biomedich-205	110	44	graphics	graphics	PROPN
biomedich-205	110	45	geforce	geforce	NOUN
biomedich-205	110	46	gtx	gtx	PROPN
biomedich-205	110	47	1060	1060	NUM
biomedich-205	110	48	.	.	PUNCT
biomedich-205	111	1	we	we	PRON
biomedich-205	111	2	did	do	VERB
biomedich-205	111	3	it	it	PRON
biomedich-205	111	4	with	with	ADP
biomedich-205	111	5	a	a	DET
biomedich-205	111	6	6	6	NUM
biomedich-205	111	7	gb	gb	NOUN
biomedich-205	111	8	card	card	NOUN
biomedich-205	111	9	.	.	PUNCT
biomedich-205	112	1	the	the	DET
biomedich-205	112	2	gromacs	gromacs	PROPN
biomedich-205	112	3	source	source	NOUN
biomedich-205	112	4	code	code	NOUN
biomedich-205	112	5	was	be	AUX
biomedich-205	112	6	taken	take	VERB
biomedich-205	112	7	from	from	ADP
biomedich-205	112	8	the	the	DET
biomedich-205	112	9	website	website	NOUN
biomedich-205	112	10	http://www.gromacs.org/	http://www.gromacs.org/	NOUN
biomedich-205	112	11	and	and	CCONJ
biomedich-205	112	12	built	build	VERB
biomedich-205	112	13	using	use	VERB
biomedich-205	112	14	opencl	opencl	NOUN
biomedich-205	112	15	version	version	PROPN
biomedich-205	112	16	1.2	1.2	NUM
biomedich-205	112	17	of	of	ADP
biomedich-205	112	18	microsoft	microsoft	PROPN
biomedich-205	112	19	visual	visual	PROPN
biomedich-205	112	20	studio	studio	PROPN
biomedich-205	112	21	community	community	NOUN
biomedich-205	112	22	msvc19.16.27025.1	msvc19.16.27025.1	NOUN
biomedich-205	112	23	and	and	CCONJ
biomedich-205	112	24	nvidia	nvidia	PROPN
biomedich-205	112	25	gpu	gpu	PROPN
biomedich-205	112	26	computing	computing	NOUN
biomedich-205	112	27	toolkit	toolkit	NOUN
biomedich-205	112	28	cuda	cuda	NOUN
biomedich-205	112	29	v10.0	v10.0	PROPN
biomedich-205	112	30	for	for	ADP
biomedich-205	112	31	windows	window	NOUN
biomedich-205	112	32	10	10	NUM
biomedich-205	112	33	.	.	PUNCT
biomedich-205	113	1	the	the	DET
biomedich-205	113	2	pdbqt	pdbqt	ADJ
biomedich-205	113	3	file	file	NOUN
biomedich-205	113	4	of	of	ADP
biomedich-205	113	5	the	the	DET
biomedich-205	113	6	protein	protein	NOUN
biomedich-205	113	7	-	-	PUNCT
biomedich-205	113	8	ligand	ligand	NOUN
biomedich-205	113	9	complex	complex	NOUN
biomedich-205	113	10	obtained	obtain	VERB
biomedich-205	113	11	by	by	ADP
biomedich-205	113	12	virtual	virtual	ADJ
biomedich-205	113	13	screening	screening	NOUN
biomedich-205	113	14	at	at	ADP
biomedich-205	113	15	autodock	autodock	PROPN
biomedich-205	113	16	vina	vina	PROPN
biomedich-205	113	17	is	be	AUX
biomedich-205	113	18	used	use	VERB
biomedich-205	113	19	as	as	ADP
biomedich-205	113	20	the	the	DET
biomedich-205	113	21	first	first	ADJ
biomedich-205	113	22	coordinate	coordinate	NOUN
biomedich-205	113	23	source	source	NOUN
biomedich-205	113	24	for	for	ADP
biomedich-205	113	25	both	both	DET
biomedich-205	113	26	psck9	psck9	NOUN
biomedich-205	113	27	and	and	CCONJ
biomedich-205	113	28	the	the	DET
biomedich-205	113	29	screened	screen	VERB
biomedich-205	113	30	virtual	virtual	ADJ
biomedich-205	113	31	inhibitor	inhibitor	NOUN
biomedich-205	113	32	.	.	PUNCT
biomedich-205	114	1	using	use	VERB
biomedich-205	114	2	open	open	ADJ
biomedich-205	114	3	babel	babel	NOUN
biomedich-205	114	4	,	,	PUNCT
biomedich-205	114	5	the	the	DET
biomedich-205	114	6	coordinates	coordinate	NOUN
biomedich-205	114	7	were	be	AUX
biomedich-205	114	8	converted	convert	VERB
biomedich-205	114	9	to	to	ADP
biomedich-205	114	10	in	in	ADP
biomedich-205	114	11	pdbqt	pdbqt	ADJ
biomedich-205	114	12	format	format	NOUN
biomedich-205	114	13	,	,	PUNCT
biomedich-205	114	14	pdb	pdb	PROPN
biomedich-205	114	15	for	for	ADP
biomedich-205	114	16	proteins	protein	NOUN
biomedich-205	114	17	and	and	CCONJ
biomedich-205	114	18	mol2	mol2	NOUN
biomedich-205	114	19	for	for	ADP
biomedich-205	114	20	ligands	ligand	NOUN
biomedich-205	114	21	.	.	PUNCT
biomedich-205	115	1	the	the	DET
biomedich-205	115	2	generated	generate	VERB
biomedich-205	115	3	pdbqt	pdbqt	NOUN
biomedich-205	115	4	file	file	NOUN
biomedich-205	115	5	was	be	AUX
biomedich-205	115	6	reconstructed	reconstruct	VERB
biomedich-205	115	7	in	in	ADP
biomedich-205	115	8	swissmodel	swissmodel	NOUN
biomedich-205	115	9	(	(	PUNCT
biomedich-205	115	10	waterhouse	waterhouse	PROPN
biomedich-205	115	11	et	et	PROPN
biomedich-205	115	12	al	al	PROPN
biomedich-205	115	13	.	.	PROPN
biomedich-205	115	14	,	,	PUNCT
biomedich-205	115	15	2018	2018	NUM
biomedich-205	115	16	)	)	PUNCT
biomedich-205	115	17	using	use	VERB
biomedich-205	115	18	the	the	DET
biomedich-205	115	19	entire	entire	ADJ
biomedich-205	115	20	human	human	ADJ
biomedich-205	115	21	pcsk9	pcsk9	NOUN
biomedich-205	115	22	amino	amino	NOUN
biomedich-205	115	23	acid	acid	PROPN
biomedich-205	115	24	sethuramalingam	sethuramalingam	PROPN
biomedich-205	115	25	et	et	PROPN
biomedich-205	115	26	al	al	PROPN
biomedich-205	115	27	.	.	PROPN
biomedich-205	116	1	–	–	PUNCT
biomedich-205	116	2	identification	identification	NOUN
biomedich-205	116	3	of	of	ADP
biomedich-205	116	4	pcsk9	pcsk9	NOUN
biomedich-205	116	5	inhibitors	inhibitor	VERB
biomedich-205	116	6	123	123	NUM
biomedich-205	116	7	sequence	sequence	NOUN
biomedich-205	116	8	(	(	PUNCT
biomedich-205	116	9	bateman	bateman	NOUN
biomedich-205	116	10	et	et	PROPN
biomedich-205	116	11	al	al	PROPN
biomedich-205	116	12	.	.	PROPN
biomedich-205	116	13	,	,	PUNCT
biomedich-205	116	14	2015	2015	NUM
biomedich-205	116	15	;	;	PUNCT
biomedich-205	116	16	leinonen	leinonen	PROPN
biomedich-205	116	17	et	et	PROPN
biomedich-205	116	18	al	al	PROPN
biomedich-205	116	19	.	.	PROPN
biomedich-205	116	20	,	,	PUNCT
biomedich-205	116	21	2004	2004	NUM
biomedich-205	116	22	)	)	PUNCT
biomedich-205	116	23	and	and	CCONJ
biomedich-205	116	24	lacked	lack	VERB
biomedich-205	116	25	the	the	DET
biomedich-205	116	26	original	original	ADJ
biomedich-205	116	27	3d	3d	NUM
biomedich-205	116	28	structure	structure	NOUN
biomedich-205	116	29	.	.	PUNCT
biomedich-205	117	1	i	i	PRON
biomedich-205	117	2	filled	fill	VERB
biomedich-205	117	3	in	in	ADP
biomedich-205	117	4	the	the	DET
biomedich-205	117	5	loop	loop	NOUN
biomedich-205	117	6	that	that	PRON
biomedich-205	117	7	is	be	AUX
biomedich-205	117	8	.	.	PUNCT
biomedich-205	118	1	new	new	ADJ
biomedich-205	118	2	pdb	pdb	PROPN
biomedich-205	118	3	coordinates	coordinate	NOUN
biomedich-205	118	4	were	be	AUX
biomedich-205	118	5	retrieved	retrieve	VERB
biomedich-205	118	6	and	and	CCONJ
biomedich-205	118	7	utilised	utilise	VERB
biomedich-205	118	8	by	by	ADP
biomedich-205	118	9	gmx	gmx	PROPN
biomedich-205	118	10	pdb2gmx	pdb2gmx	PROPN
biomedich-205	118	11	with	with	ADP
biomedich-205	118	12	the	the	DET
biomedich-205	118	13	charmm36	charmm36	NOUN
biomedich-205	118	14	allatom	allatom	NOUN
biomedich-205	118	15	force	force	NOUN
biomedich-205	118	16	field	field	NOUN
biomedich-205	118	17	to	to	PART
biomedich-205	118	18	generate	generate	VERB
biomedich-205	118	19	the	the	DET
biomedich-205	118	20	gro	gro	NOUN
biomedich-205	118	21	protein	protein	NOUN
biomedich-205	118	22	topology	topology	NOUN
biomedich-205	118	23	(	(	PUNCT
biomedich-205	118	24	july	july	PROPN
biomedich-205	118	25	2020	2020	NUM
biomedich-205	118	26	)	)	PUNCT
biomedich-205	118	27	.	.	PUNCT
biomedich-205	119	1	in	in	ADP
biomedich-205	119	2	the	the	DET
biomedich-205	119	3	avogadro	avogadro	NOUN
biomedich-205	119	4	programme	programme	NOUN
biomedich-205	119	5	(	(	PUNCT
biomedich-205	119	6	http://	http://	PROPN
biomedich-205	119	7	avogadro.cc/	avogadro.cc/	PROPN
biomedich-205	119	8	)	)	PUNCT
biomedich-205	119	9	(	(	PUNCT
biomedich-205	119	10	hanwell	hanwell	PROPN
biomedich-205	119	11	et	et	PROPN
biomedich-205	119	12	al	al	PROPN
biomedich-205	119	13	.	.	PROPN
biomedich-205	119	14	,	,	PUNCT
biomedich-205	119	15	2012	2012	NUM
biomedich-205	119	16	)	)	PUNCT
biomedich-205	119	17	,	,	PUNCT
biomedich-205	119	18	mol2	mol2	PROPN
biomedich-205	119	19	files	file	NOUN
biomedich-205	119	20	were	be	AUX
biomedich-205	119	21	updated	update	VERB
biomedich-205	119	22	with	with	ADP
biomedich-205	119	23	all	all	DET
biomedich-205	119	24	the	the	DET
biomedich-205	119	25	missing	miss	VERB
biomedich-205	119	26	hydrogen	hydrogen	NOUN
biomedich-205	119	27	atoms	atom	NOUN
biomedich-205	119	28	.	.	PUNCT
biomedich-205	120	1	the	the	DET
biomedich-205	120	2	updated	update	VERB
biomedich-205	120	3	mol2	mol2	PROPN
biomedich-205	120	4	files	file	NOUN
biomedich-205	120	5	were	be	AUX
biomedich-205	120	6	visually	visually	ADV
biomedich-205	120	7	verified	verify	VERB
biomedich-205	120	8	and	and	CCONJ
biomedich-205	120	9	modified	modify	VERB
biomedich-205	120	10	for	for	ADP
biomedich-205	120	11	problems	problem	NOUN
biomedich-205	120	12	.	.	PUNCT
biomedich-205	121	1	using	use	VERB
biomedich-205	121	2	sort	sort	ADJ
biomedich-205	121	3	mol2	mol2	PROPN
biomedich-205	121	4	bonds	bond	NOUN
biomedich-205	121	5	,	,	PUNCT
biomedich-205	121	6	a	a	DET
biomedich-205	121	7	perl	perl	NOUN
biomedich-205	121	8	script	script	NOUN
biomedich-205	121	9	created	create	VERB
biomedich-205	121	10	by	by	ADP
biomedich-205	121	11	justin	justin	PROPN
biomedich-205	121	12	a.	a.	PROPN
biomedich-205	121	13	lemkul	lemkul	PROPN
biomedich-205	121	14	and	and	CCONJ
biomedich-205	121	15	provided	provide	VERB
biomedich-205	121	16	under	under	ADP
biomedich-205	121	17	the	the	DET
biomedich-205	121	18	gpl3.0	gpl3.0	ADJ
biomedich-205	121	19	licence	licence	NOUN
biomedich-205	121	20	,	,	PUNCT
biomedich-205	121	21	the	the	DET
biomedich-205	121	22	bonds	bond	NOUN
biomedich-205	121	23	in	in	ADP
biomedich-205	121	24	the	the	DET
biomedich-205	121	25	coordinate	coordinate	NOUN
biomedich-205	121	26	files	file	NOUN
biomedich-205	121	27	were	be	AUX
biomedich-205	121	28	separated	separate	VERB
biomedich-205	121	29	in	in	ADP
biomedich-205	121	30	ascending	ascend	VERB
biomedich-205	121	31	order	order	NOUN
biomedich-205	121	32	.	.	PUNCT
biomedich-205	122	1	such	such	ADJ
biomedich-205	122	2	processed	process	VERB
biomedich-205	122	3	mol2	mol2	PROPN
biomedich-205	122	4	data	datum	NOUN
biomedich-205	122	5	was	be	AUX
biomedich-205	122	6	sent	send	VERB
biomedich-205	122	7	to	to	ADP
biomedich-205	122	8	swissparam	swissparam	PROPN
biomedich-205	122	9	(	(	PUNCT
biomedich-205	122	10	https://swissparam.ch/	https://swissparam.ch/	PROPN
biomedich-205	122	11	)	)	PUNCT
biomedich-205	122	12	to	to	PART
biomedich-205	122	13	build	build	VERB
biomedich-205	122	14	a	a	DET
biomedich-205	122	15	ligand	ligand	ADJ
biomedich-205	122	16	topology	topology	NOUN
biomedich-205	122	17	for	for	ADP
biomedich-205	122	18	retrieving	retrieve	VERB
biomedich-205	122	19	“	"	PUNCT
biomedich-205	122	20	itp	itp	NOUN
biomedich-205	122	21	and	and	CCONJ
biomedich-205	122	22	pdb	pdb	NOUN
biomedich-205	122	23	”	"	PUNCT
biomedich-205	122	24	files	file	NOUN
biomedich-205	122	25	.	.	PUNCT
biomedich-205	123	1	the	the	DET
biomedich-205	123	2	received	receive	VERB
biomedich-205	123	3	pdb	pdb	NOUN
biomedich-205	123	4	file	file	NOUN
biomedich-205	123	5	was	be	AUX
biomedich-205	123	6	converted	convert	VERB
biomedich-205	123	7	to	to	ADP
biomedich-205	123	8	gro	gro	NOUN
biomedich-205	123	9	using	use	VERB
biomedich-205	123	10	gmxeditconf	gmxeditconf	PROPN
biomedich-205	123	11	and	and	CCONJ
biomedich-205	123	12	the	the	DET
biomedich-205	123	13	itp	itp	PROPN
biomedich-205	123	14	file	file	NOUN
biomedich-205	123	15	was	be	AUX
biomedich-205	123	16	correctly	correctly	ADV
biomedich-205	123	17	placed	place	VERB
biomedich-205	123	18	in	in	ADP
biomedich-205	123	19	the	the	DET
biomedich-205	123	20	respective	respective	ADJ
biomedich-205	123	21	topol.top	topol.top	NOUN
biomedich-205	123	22	file	file	NOUN
biomedich-205	123	23	for	for	ADP
biomedich-205	123	24	each	each	DET
biomedich-205	123	25	ligand	ligand	NOUN
biomedich-205	123	26	.	.	PUNCT
biomedich-205	124	1	next	next	ADV
biomedich-205	124	2	,	,	PUNCT
biomedich-205	124	3	we	we	PRON
biomedich-205	124	4	defined	define	VERB
biomedich-205	124	5	the	the	DET
biomedich-205	124	6	unit	unit	NOUN
biomedich-205	124	7	cell	cell	NOUN
biomedich-205	124	8	and	and	CCONJ
biomedich-205	124	9	filled	fill	VERB
biomedich-205	124	10	it	it	PRON
biomedich-205	124	11	with	with	ADP
biomedich-205	124	12	water	water	NOUN
biomedich-205	124	13	.	.	PUNCT
biomedich-205	125	1	gmxeditconf	gmxeditconf	PROPN
biomedich-205	125	2	generated	generate	VERB
biomedich-205	125	3	a	a	DET
biomedich-205	125	4	dodecahedron	dodecahedron	NOUN
biomedich-205	125	5	cell	cell	NOUN
biomedich-205	125	6	from	from	ADP
biomedich-205	125	7	the	the	DET
biomedich-205	125	8	proteinligandgro	proteinligandgro	NOUN
biomedich-205	125	9	file	file	NOUN
biomedich-205	125	10	and	and	CCONJ
biomedich-205	125	11	the	the	DET
biomedich-205	125	12	correct	correct	ADJ
biomedich-205	125	13	topol.top	topol.top	NOUN
biomedich-205	125	14	file	file	NOUN
biomedich-205	125	15	.	.	PUNCT
biomedich-205	126	1	sodium	sodium	NOUN
biomedich-205	126	2	and	and	CCONJ
biomedich-205	126	3	chloride	chloride	NOUN
biomedich-205	126	4	ions	ion	NOUN
biomedich-205	126	5	were	be	AUX
biomedich-205	126	6	added	add	VERB
biomedich-205	126	7	to	to	PART
biomedich-205	126	8	achieve	achieve	VERB
biomedich-205	126	9	a	a	DET
biomedich-205	126	10	concentration	concentration	NOUN
biomedich-205	126	11	of	of	ADP
biomedich-205	126	12	0.155	0.155	NUM
biomedich-205	126	13	m	m	NOUN
biomedich-205	126	14	with	with	ADP
biomedich-205	126	15	a	a	DET
biomedich-205	126	16	neutral	neutral	ADJ
biomedich-205	126	17	charge	charge	NOUN
biomedich-205	126	18	while	while	SCONJ
biomedich-205	126	19	energy	energy	NOUN
biomedich-205	126	20	was	be	AUX
biomedich-205	126	21	minimised	minimise	VERB
biomedich-205	126	22	.	.	PUNCT
biomedich-205	127	1	the	the	DET
biomedich-205	127	2	ligands	ligand	NOUN
biomedich-205	127	3	and	and	CCONJ
biomedich-205	127	4	protein	protein	NOUN
biomedich-205	127	5	were	be	AUX
biomedich-205	127	6	individually	individually	ADV
biomedich-205	127	7	restrained	restrain	VERB
biomedich-205	127	8	by	by	ADP
biomedich-205	127	9	constructing	construct	VERB
biomedich-205	127	10	position	position	NOUN
biomedich-205	127	11	restraint	restraint	NOUN
biomedich-205	127	12	topologies	topology	NOUN
biomedich-205	127	13	,	,	PUNCT
biomedich-205	127	14	and	and	CCONJ
biomedich-205	127	15	twophase	twophase	PROPN
biomedich-205	127	16	100	100	NUM
biomedich-205	127	17	ps	ps	NOUN
biomedich-205	127	18	,	,	PUNCT
biomedich-205	127	19	310	310	NUM
biomedich-205	127	20	k	k	NOUN
biomedich-205	127	21	,	,	PUNCT
biomedich-205	127	22	and	and	CCONJ
biomedich-205	127	23	1	1	NUM
biomedich-205	127	24	bar	bar	NOUN
biomedich-205	127	25	equilibrations	equilibration	NOUN
biomedich-205	127	26	were	be	AUX
biomedich-205	127	27	carried	carry	VERB
biomedich-205	127	28	out	out	ADP
biomedich-205	127	29	to	to	PART
biomedich-205	127	30	create	create	VERB
biomedich-205	127	31	first	first	ADJ
biomedich-205	127	32	nvt	nvt	PROPN
biomedich-205	127	33	and	and	CCONJ
biomedich-205	127	34	then	then	ADV
biomedich-205	127	35	npt	npt	PROPN
biomedich-205	127	36	outputs	output	NOUN
biomedich-205	127	37	.	.	PUNCT
biomedich-205	128	1	terminal	terminal	VERB
biomedich-205	128	2	molecular	molecular	ADJ
biomedich-205	128	3	dynamics	dynamic	NOUN
biomedich-205	128	4	production	production	NOUN
biomedich-205	128	5	was	be	AUX
biomedich-205	128	6	set	set	VERB
biomedich-205	128	7	for	for	ADP
biomedich-205	128	8	“	"	PUNCT
biomedich-205	128	9	10	10	NUM
biomedich-205	128	10	nanoseconds	nanosecond	NOUN
biomedich-205	128	11	”	"	PUNCT
biomedich-205	128	12	of	of	ADP
biomedich-205	128	13	simulation	simulation	NOUN
biomedich-205	128	14	at	at	ADP
biomedich-205	128	15	320	320	NUM
biomedich-205	128	16	kelvin	kelvin	PROPN
biomedich-205	128	17	and	and	CCONJ
biomedich-205	128	18	1	1	NUM
biomedich-205	128	19	bar	bar	NOUN
biomedich-205	128	20	of	of	ADP
biomedich-205	128	21	pressure	pressure	NOUN
biomedich-205	128	22	,	,	PUNCT
biomedich-205	128	23	and	and	CCONJ
biomedich-205	128	24	a	a	DET
biomedich-205	128	25	single	single	ADJ
biomedich-205	128	26	simulation	simulation	NOUN
biomedich-205	128	27	of	of	ADP
biomedich-205	128	28	a	a	DET
biomedich-205	128	29	proteinligandcombination	proteinligandcombination	NOUN
biomedich-205	128	30	on	on	ADP
biomedich-205	128	31	the	the	DET
biomedich-205	128	32	previously	previously	ADV
biomedich-205	128	33	reported	report	VERB
biomedich-205	128	34	computer	computer	NOUN
biomedich-205	128	35	equipment	equipment	NOUN
biomedich-205	128	36	lasted	last	VERB
biomedich-205	128	37	around	around	ADP
biomedich-205	128	38	24	24	NUM
biomedich-205	128	39	hours	hour	NOUN
biomedich-205	128	40	.	.	PUNCT
biomedich-205	129	1	for	for	ADP
biomedich-205	129	2	both	both	PRON
biomedich-205	129	3	energy	energy	NOUN
biomedich-205	129	4	minimization	minimization	NOUN
biomedich-205	129	5	and	and	CCONJ
biomedich-205	129	6	equilibration	equilibration	NOUN
biomedich-205	129	7	,	,	PUNCT
biomedich-205	129	8	the	the	DET
biomedich-205	129	9	similar	similar	ADJ
biomedich-205	129	10	temperature	temperature	NOUN
biomedich-205	129	11	and	and	CCONJ
biomedich-205	129	12	pressure	pressure	NOUN
biomedich-205	129	13	conditions	condition	NOUN
biomedich-205	129	14	were	be	AUX
biomedich-205	129	15	employed	employ	VERB
biomedich-205	129	16	.	.	PUNCT
biomedich-205	130	1	visual	visual	ADJ
biomedich-205	130	2	molecular	molecular	ADJ
biomedich-205	130	3	dynamics	dynamic	NOUN
biomedich-205	130	4	(	(	PUNCT
biomedich-205	130	5	vmd	vmd	NOUN
biomedich-205	130	6	)	)	PUNCT
biomedich-205	130	7	(	(	PUNCT
biomedich-205	130	8	yamada	yamada	PROPN
biomedich-205	130	9	et	et	PROPN
biomedich-205	130	10	al	al	PROPN
biomedich-205	130	11	.	.	PROPN
biomedich-205	130	12	,	,	PUNCT
biomedich-205	130	13	2017	2017	NUM
biomedich-205	130	14	)	)	PUNCT
biomedich-205	130	15	was	be	AUX
biomedich-205	130	16	used	use	VERB
biomedich-205	130	17	to	to	PART
biomedich-205	130	18	visualise	visualise	VERB
biomedich-205	130	19	the	the	DET
biomedich-205	130	20	results	result	NOUN
biomedich-205	130	21	,	,	PUNCT
biomedich-205	130	22	and	and	CCONJ
biomedich-205	130	23	gromacs	gromacs	PROPN
biomedich-205	130	24	gmx	gmx	PROPN
biomedich-205	130	25	rms	rm	NOUN
biomedich-205	130	26	was	be	AUX
biomedich-205	130	27	used	use	VERB
biomedich-205	130	28	to	to	PART
biomedich-205	130	29	determine	determine	VERB
biomedich-205	130	30	the	the	DET
biomedich-205	130	31	rootmeansquare	rootmeansquare	NOUN
biomedich-205	130	32	deviation	deviation	NOUN
biomedich-205	130	33	(	(	PUNCT
biomedich-205	130	34	rmsd	rmsd	NOUN
biomedich-205	130	35	)	)	PUNCT
biomedich-205	130	36	.	.	PUNCT
biomedich-205	131	1	results	result	NOUN
biomedich-205	131	2	and	and	CCONJ
biomedich-205	131	3	discussion	discussion	NOUN
biomedich-205	131	4	results	result	VERB
biomedich-205	131	5	active	active	ADJ
biomedich-205	131	6	site	site	NOUN
biomedich-205	131	7	3d	3d	NUM
biomedich-205	131	8	structure	structure	NOUN
biomedich-205	131	9	of	of	ADP
biomedich-205	131	10	the	the	DET
biomedich-205	131	11	target	target	NOUN
biomedich-205	131	12	protein	protein	NOUN
biomedich-205	131	13	(	(	PUNCT
biomedich-205	131	14	pcsk9	pcsk9	NOUN
biomedich-205	131	15	)	)	PUNCT
biomedich-205	131	16	figure	figure	NOUN
biomedich-205	131	17	1	1	NUM
biomedich-205	131	18	shows	show	VERB
biomedich-205	131	19	the	the	DET
biomedich-205	131	20	ligplot	ligplot	NOUN
biomedich-205	131	21	of	of	ADP
biomedich-205	131	22	the	the	DET
biomedich-205	131	23	structure	structure	NOUN
biomedich-205	131	24	expressing	express	VERB
biomedich-205	131	25	the	the	DET
biomedich-205	131	26	residues	residue	NOUN
biomedich-205	131	27	participated	participate	VERB
biomedich-205	131	28	in	in	ADP
biomedich-205	131	29	the	the	DET
biomedich-205	131	30	interaction	interaction	NOUN
biomedich-205	131	31	.	.	PUNCT
biomedich-205	132	1	the	the	DET
biomedich-205	132	2	dashed	dash	VERB
biomedich-205	132	3	line	line	NOUN
biomedich-205	132	4	shows	show	VERB
biomedich-205	132	5	the	the	DET
biomedich-205	132	6	hydrogen	hydrogen	NOUN
biomedich-205	132	7	bond	bond	NOUN
biomedich-205	132	8	interaction	interaction	NOUN
biomedich-205	132	9	between	between	ADP
biomedich-205	132	10	the	the	DET
biomedich-205	132	11	amino	amino	NOUN
biomedich-205	132	12	acids	acid	NOUN
biomedich-205	132	13	and	and	CCONJ
biomedich-205	132	14	legends	legend	NOUN
biomedich-205	132	15	of	of	ADP
biomedich-205	132	16	the	the	DET
biomedich-205	132	17	target	target	NOUN
biomedich-205	132	18	protein	protein	NOUN
biomedich-205	132	19	.	.	PUNCT
biomedich-205	133	1	figure	figure	NOUN
biomedich-205	133	2	2	2	NUM
biomedich-205	133	3	uses	use	VERB
biomedich-205	133	4	discovery	discovery	NOUN
biomedich-205	133	5	studio	studio	NOUN
biomedich-205	133	6	to	to	PART
biomedich-205	133	7	contrast	contrast	VERB
biomedich-205	133	8	this	this	DET
biomedich-205	133	9	interaction	interaction	NOUN
biomedich-205	133	10	and	and	CCONJ
biomedich-205	133	11	distinguish	distinguish	VERB
biomedich-205	133	12	the	the	DET
biomedich-205	133	13	active	active	ADJ
biomedich-205	133	14	area	area	NOUN
biomedich-205	133	15	residues	residue	NOUN
biomedich-205	133	16	from	from	ADP
biomedich-205	133	17	the	the	DET
biomedich-205	133	18	rest	rest	NOUN
biomedich-205	133	19	of	of	ADP
biomedich-205	133	20	the	the	DET
biomedich-205	133	21	structure	structure	NOUN
biomedich-205	133	22	.	.	PUNCT
biomedich-205	134	1	figure	figure	NOUN
biomedich-205	134	2	2	2	NUM
biomedich-205	134	3	.	.	PUNCT
biomedich-205	134	4	active	active	ADJ
biomedich-205	134	5	cite	cite	VERB
biomedich-205	134	6	pocket	pocket	NOUN
biomedich-205	134	7	.	.	PUNCT
biomedich-205	135	1	(	(	PUNCT
biomedich-205	135	2	figure	figure	NOUN
biomedich-205	135	3	2	2	NUM
biomedich-205	135	4	)	)	PUNCT
biomedich-205	135	5	ball	ball	NOUN
biomedich-205	135	6	sticks	stick	NOUN
biomedich-205	135	7	representation	representation	NOUN
biomedich-205	135	8	of	of	ADP
biomedich-205	135	9	active	active	ADJ
biomedich-205	135	10	site	site	NOUN
biomedich-205	135	11	pocket	pocket	NOUN
biomedich-205	135	12	utilizing	utilize	VERB
biomedich-205	135	13	molecular	molecular	ADJ
biomedich-205	135	14	docking	docking	NOUN
biomedich-205	135	15	research	research	NOUN
biomedich-205	135	16	to	to	PART
biomedich-205	135	17	identify	identify	VERB
biomedich-205	135	18	known	know	VERB
biomedich-205	135	19	inhibitors	inhibitor	NOUN
biomedich-205	135	20	for	for	ADP
biomedich-205	135	21	pharmacophore	pharmacophore	ADJ
biomedich-205	135	22	design	design	NOUN
biomedich-205	135	23	.	.	PUNCT
biomedich-205	136	1	to	to	PART
biomedich-205	136	2	identify	identify	VERB
biomedich-205	136	3	the	the	DET
biomedich-205	136	4	optimal	optimal	ADJ
biomedich-205	136	5	structure	structure	NOUN
biomedich-205	136	6	of	of	ADP
biomedich-205	136	7	pcsk9	pcsk9	PROPN
biomedich-205	136	8	and	and	CCONJ
biomedich-205	136	9	its	its	PRON
biomedich-205	136	10	active	active	ADJ
biomedich-205	136	11	sites	site	NOUN
biomedich-205	136	12	and	and	CCONJ
biomedich-205	136	13	recognized	recognize	VERB
biomedich-205	136	14	ace	ace	NOUN
biomedich-205	136	15	inhibitors	inhibitor	NOUN
biomedich-205	136	16	such	such	ADJ
biomedich-205	136	17	as	as	ADP
biomedich-205	136	18	,	,	PUNCT
biomedich-205	136	19	“	"	PUNCT
biomedich-205	136	20	captopril	captopril	NOUN
biomedich-205	136	21	,	,	PUNCT
biomedich-205	136	22	zophenopril	zophenopril	NOUN
biomedich-205	136	23	,	,	PUNCT
biomedich-205	136	24	enalapril	enalapril	PROPN
biomedich-205	136	25	,	,	PUNCT
biomedich-205	136	26	ramipril	ramipril	NOUN
biomedich-205	136	27	,	,	PUNCT
biomedich-205	136	28	quinapril	quinapril	NOUN
biomedich-205	136	29	,	,	PUNCT
biomedich-205	136	30	perindopril	perindopril	ADJ
biomedich-205	136	31	,	,	PUNCT
biomedich-205	136	32	lisinopril	lisinopril	PROPN
biomedich-205	136	33	,	,	PUNCT
biomedich-205	136	34	benazepril	benazepril	ADJ
biomedich-205	136	35	,	,	PUNCT
biomedich-205	136	36	fosinopril	fosinopril	ADJ
biomedich-205	136	37	,	,	PUNCT
biomedich-205	136	38	silazapril	silazapril	NOUN
biomedich-205	136	39	,	,	PUNCT
biomedich-205	136	40	moexipril	moexipril	NOUN
biomedich-205	136	41	,	,	PUNCT
biomedich-205	136	42	trandolapril	trandolapril	PROPN
biomedich-205	136	43	,	,	PUNCT
biomedich-205	136	44	alicin	alicin	PROPN
biomedich-205	136	45	”	"	PUNCT
biomedich-205	136	46	,	,	PUNCT
biomedich-205	136	47	etc	etc	X
biomedich-205	136	48	.	.	X
biomedich-205	137	1	we	we	PRON
biomedich-205	137	2	reviewed	review	VERB
biomedich-205	137	3	the	the	DET
biomedich-205	137	4	literature	literature	NOUN
biomedich-205	137	5	in	in	ADP
biomedich-205	137	6	(	(	PUNCT
biomedich-205	137	7	s1	s1	NOUN
biomedich-205	137	8	table	table	NOUN
biomedich-205	137	9	)	)	PUNCT
biomedich-205	137	10	.	.	PUNCT
biomedich-205	138	1	all	all	DET
biomedich-205	138	2	known	know	VERB
biomedich-205	138	3	acei	acei	NOUN
biomedich-205	138	4	were	be	AUX
biomedich-205	138	5	docked	dock	VERB
biomedich-205	138	6	to	to	ADP
biomedich-205	138	7	the	the	DET
biomedich-205	138	8	target	target	NOUN
biomedich-205	138	9	protein	protein	NOUN
biomedich-205	138	10	pcsk9	pcsk9	NOUN
biomedich-205	138	11	and	and	CCONJ
biomedich-205	138	12	the	the	DET
biomedich-205	138	13	top	top	ADJ
biomedich-205	138	14	results	result	NOUN
biomedich-205	138	15	were	be	AUX
biomedich-205	138	16	evaluated	evaluate	VERB
biomedich-205	138	17	based	base	VERB
biomedich-205	138	18	on	on	ADP
biomedich-205	138	19	the	the	DET
biomedich-205	138	20	interaction	interaction	NOUN
biomedich-205	138	21	between	between	ADP
biomedich-205	138	22	binding	bind	VERB
biomedich-205	138	23	energy	energy	NOUN
biomedich-205	138	24	and	and	CCONJ
biomedich-205	138	25	the	the	DET
biomedich-205	138	26	active	active	ADJ
biomedich-205	138	27	site	site	NOUN
biomedich-205	138	28	.	.	PUNCT
biomedich-205	139	1	molecules	molecule	NOUN
biomedich-205	139	2	evaluated	evaluate	VERB
biomedich-205	139	3	on	on	ADP
biomedich-205	139	4	the	the	DET
biomedich-205	139	5	basis	basis	NOUN
biomedich-205	139	6	of	of	ADP
biomedich-205	139	7	pharmacophore	pharmacophore	NOUN
biomedich-205	139	8	in	in	ADP
biomedich-205	139	9	this	this	DET
biomedich-205	139	10	study	study	NOUN
biomedich-205	139	11	,	,	PUNCT
biomedich-205	139	12	pharmacophore	pharmacophore	PROPN
biomedich-205	139	13	was	be	AUX
biomedich-205	139	14	adopted	adopt	VERB
biomedich-205	139	15	as	as	ADP
biomedich-205	139	16	a	a	DET
biomedich-205	139	17	drug	drug	NOUN
biomedich-205	139	18	discovery	discovery	NOUN
biomedich-205	139	19	strategy	strategy	NOUN
biomedich-205	139	20	and	and	CCONJ
biomedich-205	139	21	a	a	DET
biomedich-205	139	22	novel	novel	ADJ
biomedich-205	139	23	pcsk9	pcsk9	NOUN
biomedich-205	139	24	inhibitor	inhibitor	NOUN
biomedich-205	139	25	was	be	AUX
biomedich-205	139	26	used	use	VERB
biomedich-205	139	27	with	with	ADP
biomedich-205	139	28	established	establish	VERB
biomedich-205	139	29	inhibitors	inhibitor	NOUN
biomedich-205	139	30	such	such	ADJ
biomedich-205	139	31	as	as	ADP
biomedich-205	139	32	,	,	PUNCT
biomedich-205	139	33	“	"	PUNCT
biomedich-205	139	34	moexipril	moexipril	NOUN
biomedich-205	139	35	,	,	PUNCT
biomedich-205	139	36	trandolapril	trandolapril	PROPN
biomedich-205	139	37	,	,	PUNCT
biomedich-205	139	38	alicin	alicin	PROPN
biomedich-205	139	39	,	,	PUNCT
biomedich-205	139	40	teprotide	teprotide	ADJ
biomedich-205	139	41	,	,	PUNCT
biomedich-205	139	42	zophenopril	zophenopril	NOUN
biomedich-205	139	43	,	,	PUNCT
biomedich-205	139	44	ramipril	ramipril	NOUN
biomedich-205	139	45	,	,	PUNCT
biomedich-205	139	46	quinapril	quinapril	NOUN
biomedich-205	139	47	”	"	PUNCT
biomedich-205	139	48	shown	show	VERB
biomedich-205	139	49	in	in	ADP
biomedich-205	139	50	table	table	NOUN
biomedich-205	139	51	s1	s1	NOUN
biomedich-205	139	52	.	.	PUNCT
biomedich-205	140	1	the	the	DET
biomedich-205	140	2	pharmacophore	pharmacophore	NOUN
biomedich-205	140	3	model	model	NOUN
biomedich-205	140	4	created	create	VERB
biomedich-205	140	5	by	by	ADP
biomedich-205	140	6	pharmagist	pharmagist	NOUN
biomedich-205	140	7	was	be	AUX
biomedich-205	140	8	evaluated	evaluate	VERB
biomedich-205	140	9	and	and	CCONJ
biomedich-205	140	10	the	the	DET
biomedich-205	140	11	optimal	optimal	ADJ
biomedich-205	140	12	pharmacophore	pharmacophore	NOUN
biomedich-205	140	13	was	be	AUX
biomedich-205	140	14	selected	select	VERB
biomedich-205	140	15	based	base	VERB
biomedich-205	140	16	on	on	ADP
biomedich-205	140	17	a	a	DET
biomedich-205	140	18	score	score	NOUN
biomedich-205	140	19	of	of	ADP
biomedich-205	140	20	18.102	18.102	NUM
biomedich-205	140	21	and	and	CCONJ
biomedich-205	140	22	5	5	NUM
biomedich-205	140	23	attributes	attribute	NOUN
biomedich-205	140	24	(	(	PUNCT
biomedich-205	140	25	1	1	NUM
biomedich-205	140	26	hydrophobicity	hydrophobicity	NOUN
biomedich-205	140	27	,	,	PUNCT
biomedich-205	140	28	1	1	NUM
biomedich-205	140	29	negative	negative	ADJ
biomedich-205	140	30	ion	ion	NOUN
biomedich-205	140	31	,	,	PUNCT
biomedich-205	140	32	and	and	CCONJ
biomedich-205	140	33	3	3	NUM
biomedich-205	140	34	hydrogen	hydrogen	NOUN
biomedich-205	140	35	bond	bond	NOUN
biomedich-205	140	36	acceptors	acceptor	NOUN
biomedich-205	140	37	)	)	PUNCT
biomedich-205	140	38	.	.	PUNCT
biomedich-205	141	1	rice	rice	NOUN
biomedich-205	141	2	field	field	NOUN
biomedich-205	141	3	.	.	PUNCT
biomedich-205	142	1	in	in	ADP
biomedich-205	142	2	zincpharmer	zincpharmer	PROPN
biomedich-205	142	3	,	,	PUNCT
biomedich-205	142	4	pharmacophores	pharmacophore	NOUN
biomedich-205	142	5	were	be	AUX
biomedich-205	142	6	screened	screen	VERB
biomedich-205	142	7	along	along	ADP
biomedich-205	142	8	the	the	DET
biomedich-205	142	9	entire	entire	ADJ
biomedich-205	142	10	zink	zink	NOUN
biomedich-205	142	11	drug	drug	NOUN
biomedich-205	142	12	database	database	NOUN
biomedich-205	142	13	and	and	CCONJ
biomedich-205	142	14	1033	1033	NUM
biomedich-205	142	15	hits	hit	NOUN
biomedich-205	142	16	/	/	SYM
biomedich-205	142	17	molecule	molecule	NOUN
biomedich-205	142	18	were	be	AUX
biomedich-205	142	19	identified	identify	VERB
biomedich-205	142	20	.	.	PUNCT
biomedich-205	143	1	molecular	molecular	ADJ
biomedich-205	143	2	docking	docking	NOUN
biomedich-205	143	3	to	to	PART
biomedich-205	143	4	identify	identify	VERB
biomedich-205	143	5	the	the	DET
biomedich-205	143	6	top	top	ADJ
biomedich-205	143	7	10	10	NUM
biomedich-205	143	8	most	most	ADV
biomedich-205	143	9	promising	promising	ADJ
biomedich-205	143	10	medicinal	medicinal	ADJ
biomedich-205	143	11	candidates	candidate	NOUN
biomedich-205	143	12	after	after	ADP
biomedich-205	143	13	evaluating	evaluate	VERB
biomedich-205	143	14	all	all	DET
biomedich-205	143	15	1033	1033	NUM
biomedich-205	143	16	molecular	molecular	ADJ
biomedich-205	143	17	docking	docking	NOUN
biomedich-205	143	18	complexes	complex	NOUN
biomedich-205	143	19	with	with	ADP
biomedich-205	143	20	the	the	DET
biomedich-205	143	21	required	require	VERB
biomedich-205	143	22	protein	protein	NOUN
biomedich-205	143	23	,	,	PUNCT
biomedich-205	143	24	their	their	PRON
biomedich-205	143	25	affinity	affinity	NOUN
biomedich-205	143	26	energies	energy	NOUN
biomedich-205	143	27	and	and	CCONJ
biomedich-205	143	28	interactions	interaction	NOUN
biomedich-205	143	29	were	be	AUX
biomedich-205	143	30	saved	save	VERB
biomedich-205	143	31	.	.	PUNCT
biomedich-205	144	1	the	the	DET
biomedich-205	144	2	docking	docking	NOUN
biomedich-205	144	3	results	result	NOUN
biomedich-205	144	4	of	of	ADP
biomedich-205	144	5	the	the	DET
biomedich-205	144	6	top	top	ADJ
biomedich-205	144	7	10	10	NUM
biomedich-205	144	8	zinc	zinc	NOUN
biomedich-205	144	9	molecules	molecule	NOUN
biomedich-205	144	10	were	be	AUX
biomedich-205	144	11	sorted	sort	VERB
biomedich-205	144	12	based	base	VERB
biomedich-205	144	13	on	on	ADP
biomedich-205	144	14	the	the	DET
biomedich-205	144	15	interaction	interaction	NOUN
biomedich-205	144	16	of	of	ADP
biomedich-205	144	17	the	the	DET
biomedich-205	144	18	active	active	ADJ
biomedich-205	144	19	sites	site	NOUN
biomedich-205	144	20	assessed	assess	VERB
biomedich-205	144	21	for	for	ADP
biomedich-205	144	22	lower	low	ADJ
biomedich-205	144	23	binding	bind	VERB
biomedich-205	144	24	energies	energy	NOUN
biomedich-205	144	25	calculated	calculate	VERB
biomedich-205	144	26	by	by	ADP
biomedich-205	144	27	autodock	autodock	NOUN
biomedich-205	144	28	(	(	PUNCT
biomedich-205	144	29	table	table	NOUN
biomedich-205	144	30	2	2	NUM
biomedich-205	144	31	and	and	CCONJ
biomedich-205	144	32	figure	figure	NOUN
biomedich-205	144	33	3a–3j	3a–3j	NOUN
biomedich-205	144	34	)	)	PUNCT
biomedich-205	144	35	.	.	PUNCT
biomedich-205	145	1	lower	low	ADJ
biomedich-205	145	2	energies	energy	NOUN
biomedich-205	145	3	exhibit	exhibit	VERB
biomedich-205	145	4	stronger	strong	ADJ
biomedich-205	145	5	affinities	affinity	NOUN
biomedich-205	145	6	and	and	CCONJ
biomedich-205	145	7	sustained	sustained	ADJ
biomedich-205	145	8	interactions	interaction	NOUN
biomedich-205	145	9	.	.	PUNCT
biomedich-205	146	1	therefore	therefore	ADV
biomedich-205	146	2	,	,	PUNCT
biomedich-205	146	3	the	the	DET
biomedich-205	146	4	top	top	ADJ
biomedich-205	146	5	compounds	compound	NOUN
biomedich-205	146	6	may	may	AUX
biomedich-205	146	7	be	be	AUX
biomedich-205	146	8	more	more	ADV
biomedich-205	146	9	effective	effective	ADJ
biomedich-205	146	10	in	in	ADP
biomedich-205	146	11	exerting	exert	VERB
biomedich-205	146	12	the	the	DET
biomedich-205	146	13	expected	expect	VERB
biomedich-205	146	14	activity	activity	NOUN
biomedich-205	146	15	of	of	ADP
biomedich-205	146	16	the	the	DET
biomedich-205	146	17	pcsk9	pcsk9	NOUN
biomedich-205	146	18	and	and	CCONJ
biomedich-205	146	19	are	be	AUX
biomedich-205	146	20	therefore	therefore	ADV
biomedich-205	146	21	excellent	excellent	ADJ
biomedich-205	146	22	therapeutic	therapeutic	ADJ
biomedich-205	146	23	candidates	candidate	NOUN
biomedich-205	146	24	.	.	PUNCT
biomedich-205	147	1	124	124	NUM
biomedich-205	147	2	biology	biology	NOUN
biomedich-205	147	3	,	,	PUNCT
biomedich-205	147	4	medicine	medicine	NOUN
biomedich-205	147	5	,	,	PUNCT
biomedich-205	147	6	&	&	CCONJ
biomedich-205	147	7	natural	natural	ADJ
biomedich-205	147	8	product	product	NOUN
biomedich-205	147	9	chemistry	chemistry	NOUN
biomedich-205	147	10	11	11	NUM
biomedich-205	147	11	(	(	PUNCT
biomedich-205	147	12	2	2	NUM
biomedich-205	147	13	)	)	PUNCT
biomedich-205	147	14	,	,	PUNCT
biomedich-205	147	15	2022	2022	NUM
biomedich-205	147	16	:	:	PUNCT
biomedich-205	147	17	119	119	NUM
biomedich-205	147	18	-	-	SYM
biomedich-205	147	19	131	131	NUM
biomedich-205	147	20	final	final	ADJ
biomedich-205	147	21	10	10	NUM
biomedich-205	147	22	drug	drug	NOUN
biomedich-205	147	23	candidates	candidate	NOUN
biomedich-205	147	24	the	the	DET
biomedich-205	147	25	drugs	drug	NOUN
biomedich-205	147	26	such	such	ADJ
biomedich-205	147	27	as	as	ADP
biomedich-205	147	28	,	,	PUNCT
biomedich-205	147	29	“	"	PUNCT
biomedich-205	147	30	apomorphine	apomorphine	NOUN
biomedich-205	147	31	,	,	PUNCT
biomedich-205	147	32	oxyphencyclimine	oxyphencyclimine	NOUN
biomedich-205	147	33	,	,	PUNCT
biomedich-205	147	34	(	(	PUNCT
biomedich-205	147	35	s	s	NOUN
biomedich-205	147	36	)	)	PUNCT
biomedich-205	147	37	canadine	canadine	NOUN
biomedich-205	147	38	,	,	PUNCT
biomedich-205	147	39	naltrexone	naltrexone	PROPN
biomedich-205	147	40	,	,	PUNCT
biomedich-205	147	41	oxolinic	oxolinic	ADJ
biomedich-205	147	42	acid	acid	NOUN
biomedich-205	147	43	,	,	PUNCT
biomedich-205	147	44	norfloxacin	norfloxacin	PROPN
biomedich-205	147	45	,	,	PUNCT
biomedich-205	147	46	(	(	PUNCT
biomedich-205	147	47	r	r	NOUN
biomedich-205	147	48	)	)	PUNCT
biomedich-205	147	49	canadine	canadine	NOUN
biomedich-205	147	50	,	,	PUNCT
biomedich-205	147	51	hesperetin	hesperetin	NOUN
biomedich-205	147	52	,	,	PUNCT
biomedich-205	147	53	labetalol	labetalol	NOUN
biomedich-205	147	54	,	,	PUNCT
biomedich-205	147	55	and	and	CCONJ
biomedich-205	147	56	benolylate	benolylate	VERB
biomedich-205	147	57	”	"	PUNCT
biomedich-205	147	58	were	be	AUX
biomedich-205	147	59	the	the	DET
biomedich-205	147	60	top	top	ADJ
biomedich-205	147	61	10	10	NUM
biomedich-205	147	62	choices	choice	NOUN
biomedich-205	147	63	.	.	PUNCT
biomedich-205	148	1	table	table	NOUN
biomedich-205	148	2	s4	s4	PROPN
biomedich-205	148	3	shows	show	VERB
biomedich-205	148	4	their	their	PRON
biomedich-205	148	5	pubchemcid	pubchemcid	NOUN
biomedich-205	148	6	,	,	PUNCT
biomedich-205	148	7	name	name	NOUN
biomedich-205	148	8	,	,	PUNCT
biomedich-205	148	9	structural	structural	ADJ
biomedich-205	148	10	formula	formula	NOUN
biomedich-205	148	11	,	,	PUNCT
biomedich-205	148	12	putative	putative	ADJ
biomedich-205	148	13	characteristics	characteristic	NOUN
biomedich-205	148	14	,	,	PUNCT
biomedich-205	148	15	and	and	CCONJ
biomedich-205	148	16	drug	drug	NOUN
biomedich-205	148	17	similarity	similarity	NOUN
biomedich-205	148	18	according	accord	VERB
biomedich-205	148	19	to	to	ADP
biomedich-205	148	20	lipinski	lipinski	PROPN
biomedich-205	148	21	's	's	PART
biomedich-205	148	22	rule	rule	NOUN
biomedich-205	148	23	of	of	ADP
biomedich-205	148	24	five	five	NUM
biomedich-205	148	25	.	.	PUNCT
biomedich-205	149	1	according	accord	VERB
biomedich-205	149	2	to	to	ADP
biomedich-205	149	3	pubchem	pubchem	NOUN
biomedich-205	149	4	,	,	PUNCT
biomedich-205	149	5	apomorphine	apomorphine	NOUN
biomedich-205	149	6	(	(	PUNCT
biomedich-205	149	7	zinc00009073	zinc00009073	NOUN
biomedich-205	149	8	)	)	PUNCT
biomedich-205	149	9	is	be	AUX
biomedich-205	149	10	the	the	DET
biomedich-205	149	11	first	first	ADJ
biomedich-205	149	12	molecule	molecule	NOUN
biomedich-205	149	13	with	with	ADP
biomedich-205	149	14	the	the	DET
biomedich-205	149	15	least	least	ADJ
biomedich-205	149	16	change	change	NOUN
biomedich-205	149	17	in	in	ADP
biomedich-205	149	18	docking	dock	VERB
biomedich-205	149	19	energy	energy	NOUN
biomedich-205	149	20	,	,	PUNCT
biomedich-205	149	21	a	a	DET
biomedich-205	149	22	non	non	ADJ
biomedich-205	149	23	-	-	ADJ
biomedich-205	149	24	selective	selective	ADJ
biomedich-205	149	25	dopamine	dopamine	NOUN
biomedich-205	149	26	used	use	VERB
biomedich-205	149	27	to	to	PART
biomedich-205	149	28	treat	treat	VERB
biomedich-205	149	29	parkinson	parkinson	NOUN
biomedich-205	149	30	's	's	PART
biomedich-205	149	31	disease	disease	NOUN
biomedich-205	149	32	.	.	PUNCT
biomedich-205	150	1	oxyfencyclimin	oxyfencyclimin	ADJ
biomedich-205	150	2	(	(	PUNCT
biomedich-205	150	3	zinc00020260	zinc00020260	PROPN
biomedich-205	150	4	)	)	PUNCT
biomedich-205	150	5	is	be	AUX
biomedich-205	150	6	an	an	DET
biomedich-205	150	7	oral	oral	ADJ
biomedich-205	150	8	muscarinic	muscarinic	ADJ
biomedich-205	150	9	receptor	receptor	NOUN
biomedich-205	150	10	antagonist	antagonist	NOUN
biomedich-205	150	11	used	use	VERB
biomedich-205	150	12	to	to	PART
biomedich-205	150	13	treat	treat	VERB
biomedich-205	150	14	gastric	gastric	ADJ
biomedich-205	150	15	ulcers	ulcer	NOUN
biomedich-205	150	16	and	and	CCONJ
biomedich-205	150	17	gastrointestinal	gastrointestinal	ADJ
biomedich-205	150	18	problems	problem	NOUN
biomedich-205	150	19	.	.	PUNCT
biomedich-205	151	1	the	the	DET
biomedich-205	151	2	third	third	NOUN
biomedich-205	151	3	is	be	AUX
biomedich-205	151	4	(	(	PUNCT
biomedich-205	151	5	s	s	NOUN
biomedich-205	151	6	)	)	PUNCT
biomedich-205	151	7	canadine	canadine	NOUN
biomedich-205	151	8	which	which	PRON
biomedich-205	151	9	is	be	AUX
biomedich-205	151	10	also	also	ADV
biomedich-205	151	11	called	call	VERB
biomedich-205	151	12	as	as	ADP
biomedich-205	151	13	(	(	PUNCT
biomedich-205	151	14	s	s	NOUN
biomedich-205	151	15	)	)	PUNCT
biomedich-205	151	16	tetrahydroberberine	tetrahydroberberine	NOUN
biomedich-205	151	17	and	and	CCONJ
biomedich-205	151	18	xanthopsin	xanthopsin	PROPN
biomedich-205	151	19	(	(	PUNCT
biomedich-205	151	20	zinc00033518	zinc00033518	PROPN
biomedich-205	151	21	)	)	PUNCT
biomedich-205	151	22	,	,	PUNCT
biomedich-205	151	23	which	which	PRON
biomedich-205	151	24	is	be	AUX
biomedich-205	151	25	a	a	DET
biomedich-205	151	26	benzylisoquinoline	benzylisoquinoline	NOUN
biomedich-205	151	27	alkaloid	alkaloid	NOUN
biomedich-205	151	28	(	(	PUNCT
biomedich-205	151	29	bia	bia	PROPN
biomedich-205	151	30	)	)	PUNCT
biomedich-205	151	31	in	in	ADP
biomedich-205	151	32	the	the	DET
biomedich-205	151	33	protoberberine	protoberberine	NOUN
biomedich-205	151	34	structural	structural	ADJ
biomedich-205	151	35	subgroup	subgroup	NOUN
biomedich-205	151	36	(	(	PUNCT
biomedich-205	151	37	xu	xu	INTJ
biomedich-205	151	38	et	et	PROPN
biomedich-205	151	39	al	al	PROPN
biomedich-205	151	40	.	.	PROPN
biomedich-205	151	41	,	,	PUNCT
biomedich-205	151	42	2019	2019	NUM
biomedich-205	151	43	)	)	PUNCT
biomedich-205	151	44	and	and	CCONJ
biomedich-205	151	45	is	be	AUX
biomedich-205	151	46	found	find	VERB
biomedich-205	151	47	in	in	ADP
biomedich-205	151	48	some	some	DET
biomedich-205	151	49	poppy	poppy	NOUN
biomedich-205	151	50	and	and	CCONJ
biomedich-205	151	51	corydalis	corydali	VERB
biomedich-205	151	52	plants	plant	NOUN
biomedich-205	151	53	.	.	PUNCT
biomedich-205	152	1	the	the	DET
biomedich-205	152	2	next	next	ADJ
biomedich-205	152	3	substance	substance	NOUN
biomedich-205	152	4	(	(	PUNCT
biomedich-205	152	5	zinc00001773	zinc00001773	PROPN
biomedich-205	152	6	)	)	PUNCT
biomedich-205	152	7	is	be	AUX
biomedich-205	152	8	naltrexone	naltrexone	NOUN
biomedich-205	152	9	,	,	PUNCT
biomedich-205	152	10	which	which	PRON
biomedich-205	152	11	is	be	AUX
biomedich-205	152	12	commonly	commonly	ADV
biomedich-205	152	13	used	use	VERB
biomedich-205	152	14	to	to	PART
biomedich-205	152	15	treat	treat	VERB
biomedich-205	152	16	alcohol	alcohol	NOUN
biomedich-205	152	17	or	or	CCONJ
biomedich-205	152	18	opioid	opioid	ADJ
biomedich-205	152	19	addiction	addiction	NOUN
biomedich-205	152	20	.	.	PUNCT
biomedich-205	153	1	oxolinicacid	oxolinicacid	PROPN
biomedich-205	153	2	,	,	PUNCT
biomedich-205	153	3	zinc00001875	zinc00001875	PROPN
biomedich-205	153	4	,	,	PUNCT
biomedich-205	153	5	is	be	AUX
biomedich-205	153	6	a	a	DET
biomedich-205	153	7	synthetic	synthetic	ADJ
biomedich-205	153	8	antibiotic	antibiotic	NOUN
biomedich-205	153	9	used	use	VERB
biomedich-205	153	10	for	for	ADP
biomedich-205	153	11	veterinary	veterinary	ADJ
biomedich-205	153	12	medicine	medicine	NOUN
biomedich-205	153	13	.	.	PUNCT
biomedich-205	154	1	the	the	DET
biomedich-205	154	2	antibiotic	antibiotic	ADJ
biomedich-205	154	3	zinc00003742	zinc00003742	PROPN
biomedich-205	154	4	is	be	AUX
biomedich-205	154	5	norfloxacin	norfloxacin	PROPN
biomedich-205	154	6	,	,	PUNCT
biomedich-205	154	7	which	which	PRON
biomedich-205	154	8	has	have	VERB
biomedich-205	154	9	broadspectrum	broadspectrum	NOUN
biomedich-205	154	10	antibacterial	antibacterial	ADJ
biomedich-205	154	11	activity	activity	NOUN
biomedich-205	154	12	over	over	ADP
biomedich-205	154	13	the	the	DET
biomedich-205	154	14	gram	gram	NOUN
biomedich-205	154	15	-	-	PUNCT
biomedich-205	154	16	negative	negative	ADJ
biomedich-205	154	17	and	and	CCONJ
biomedich-205	154	18	gram	gram	NOUN
biomedich-205	154	19	-	-	PUNCT
biomedich-205	154	20	positive	positive	ADJ
biomedich-205	154	21	bacteria	bacteria	NOUN
biomedich-205	154	22	.	.	PUNCT
biomedich-205	155	1	(	(	PUNCT
biomedich-205	155	2	r	r	X
biomedich-205	155	3	)	)	PUNCT
biomedich-205	155	4	canadine	canadine	NOUN
biomedich-205	155	5	is	be	AUX
biomedich-205	155	6	an	an	DET
biomedich-205	155	7	enantiomer	enantiomer	NOUN
biomedich-205	155	8	of	of	ADP
biomedich-205	155	9	(	(	PUNCT
biomedich-205	155	10	s	s	NOUN
biomedich-205	155	11	)	)	PUNCT
biomedich-205	155	12	canadine	canadine	NOUN
biomedich-205	155	13	.	.	PUNCT
biomedich-205	156	1	zinc00039092	zinc00039092	PROPN
biomedich-205	156	2	is	be	AUX
biomedich-205	156	3	a	a	DET
biomedich-205	156	4	secondary	secondary	ADJ
biomedich-205	156	5	plant	plant	NOUN
biomedich-205	156	6	metabolic	metabolic	NOUN
biomedich-205	156	7	product	product	NOUN
biomedich-205	156	8	,	,	PUNCT
biomedich-205	156	9	hesperetin	hesperetin	NOUN
biomedich-205	156	10	,	,	PUNCT
biomedich-205	156	11	that	that	PRON
biomedich-205	156	12	acts	act	VERB
biomedich-205	156	13	as	as	ADP
biomedich-205	156	14	an	an	DET
biomedich-205	156	15	antioxidant	antioxidant	ADJ
biomedich-205	156	16	and	and	CCONJ
biomedich-205	156	17	antitumor	antitumor	PROPN
biomedich-205	156	18	agent	agent	NOUN
biomedich-205	156	19	.	.	PUNCT
biomedich-205	157	1	labetalol	labetalol	NOUN
biomedich-205	157	2	is	be	AUX
biomedich-205	157	3	the	the	DET
biomedich-205	157	4	chemical	chemical	ADJ
biomedich-205	157	5	name	name	NOUN
biomedich-205	157	6	for	for	ADP
biomedich-205	157	7	2	2	NUM
biomedich-205	157	8	hydroxy	hydroxy	NOUN
biomedich-205	157	9	5	5	NUM
biomedich-205	158	1	[	[	X
biomedich-205	158	2	(	(	PUNCT
biomedich-205	158	3	1s	1s	NUM
biomedich-205	158	4	)	)	PUNCT
biomedich-205	158	5	1	1	NUM
biomedich-205	158	6	hydroxy	hydroxy	NOUN
biomedich-205	158	7	2	2	NUM
biomedich-205	159	1	[	[	X
biomedich-205	159	2	[	[	X
biomedich-205	159	3	(	(	PUNCT
biomedich-205	159	4	2r	2r	NUM
biomedich-205	159	5	)	)	PUNCT
biomedich-205	159	6	4	4	NUM
biomedich-205	159	7	phenylbutane	phenylbutane	NOUN
biomedich-205	159	8	2	2	NUM
biomedich-205	159	9	yl	yl	NOUN
biomedich-205	159	10	]	]	PUNCT
biomedich-205	159	11	amino	amino	NOUN
biomedich-205	159	12	]	]	PUNCT
biomedich-205	159	13	ethyl	ethyl	X
biomedich-205	159	14	]	]	PUNCT
biomedich-205	159	15	benzamide	benzamide	NOUN
biomedich-205	159	16	,	,	PUNCT
biomedich-205	159	17	also	also	ADV
biomedich-205	159	18	known	know	VERB
biomedich-205	159	19	as	as	ADP
biomedich-205	159	20	zinc00000416	zinc00000416	PROPN
biomedich-205	159	21	.	.	PUNCT
biomedich-205	160	1	it	it	PRON
biomedich-205	160	2	is	be	AUX
biomedich-205	160	3	a	a	DET
biomedich-205	160	4	third	third	ADJ
biomedich-205	160	5	-	-	PUNCT
biomedich-205	160	6	generation	generation	NOUN
biomedich-205	160	7	vasodilator	vasodilator	NOUN
biomedich-205	160	8	,	,	PUNCT
biomedich-205	160	9	an	an	DET
biomedich-205	160	10	antihypertensive	antihypertensive	ADJ
biomedich-205	160	11	drug	drug	NOUN
biomedich-205	160	12	selective	selective	ADJ
biomedich-205	160	13	α1	α1	PROPN
biomedich-205	160	14	adrenergic	adrenergic	ADJ
biomedich-205	160	15	blocker	blocker	NOUN
biomedich-205	160	16	and	and	CCONJ
biomedich-205	160	17	non	non	ADJ
biomedich-205	160	18	-	-	ADJ
biomedich-205	160	19	selective	selective	ADJ
biomedich-205	160	20	β	β	ADJ
biomedich-205	160	21	-	-	ADJ
biomedich-205	160	22	adrenergic	adrenergic	ADJ
biomedich-205	160	23	blocker	blocker	NOUN
biomedich-205	160	24	.	.	PUNCT
biomedich-205	161	1	the	the	DET
biomedich-205	161	2	final	final	ADJ
biomedich-205	161	3	product	product	NOUN
biomedich-205	161	4	(	(	PUNCT
biomedich-205	161	5	zinc00001003	zinc00001003	NOUN
biomedich-205	161	6	)	)	PUNCT
biomedich-205	161	7	is	be	AUX
biomedich-205	161	8	benorilate	benorilate	ADJ
biomedich-205	161	9	,	,	PUNCT
biomedich-205	161	10	an	an	DET
biomedich-205	161	11	esterified	esterify	VERB
biomedich-205	161	12	codrug	codrug	NOUN
biomedich-205	161	13	of	of	ADP
biomedich-205	161	14	aspirin	aspirin	NOUN
biomedich-205	161	15	and	and	CCONJ
biomedich-205	161	16	acetaminophen	acetaminophen	NOUN
biomedich-205	161	17	.	.	PUNCT
biomedich-205	162	1	it	it	PRON
biomedich-205	162	2	is	be	AUX
biomedich-205	162	3	used	use	VERB
biomedich-205	162	4	as	as	ADP
biomedich-205	162	5	an	an	DET
biomedich-205	162	6	anti	anti	ADJ
biomedich-205	162	7	-	-	ADJ
biomedich-205	162	8	inflammatory	inflammatory	ADJ
biomedich-205	162	9	and	and	CCONJ
biomedich-205	162	10	antipyretic	antipyretic	ADJ
biomedich-205	162	11	drug(bass	drug(bass	PROPN
biomedich-205	162	12	,	,	PUNCT
biomedich-205	162	13	1973	1973	NUM
biomedich-205	162	14	)	)	PUNCT
biomedich-205	162	15	.	.	PUNCT
biomedich-205	163	1	figure	figure	VERB
biomedich-205	163	2	3	3	NUM
biomedich-205	163	3	.	.	PUNCT
biomedich-205	164	1	the	the	DET
biomedich-205	164	2	10	10	NUM
biomedich-205	164	3	drug	drug	NOUN
biomedich-205	164	4	candidates	candidate	NOUN
biomedich-205	164	5	.	.	PUNCT
biomedich-205	165	1	(	(	PUNCT
biomedich-205	165	2	figure	figure	NOUN
biomedich-205	165	3	3	3	NUM
biomedich-205	165	4	)	)	PUNCT
biomedich-205	165	5	it	it	PRON
biomedich-205	165	6	shows	show	VERB
biomedich-205	165	7	the	the	DET
biomedich-205	165	8	final	final	ADJ
biomedich-205	165	9	drugs	drug	NOUN
biomedich-205	165	10	table	table	NOUN
biomedich-205	165	11	4	4	NUM
biomedich-205	165	12	.	.	PUNCT
biomedich-205	165	13	pubchem	pubchem	NOUN
biomedich-205	165	14	ids	id	NOUN
biomedich-205	165	15	and	and	CCONJ
biomedich-205	165	16	names	name	NOUN
biomedich-205	165	17	of	of	ADP
biomedich-205	165	18	molecules	molecule	NOUN
biomedich-205	165	19	.	.	PUNCT
biomedich-205	166	1	molecule	molecule	NOUN
biomedich-205	166	2	name	name	NOUN
biomedich-205	166	3	cids	cid	NOUN
biomedich-205	166	4	le	le	X
biomedich-205	166	5	lelp	lelp	PROPN
biomedich-205	166	6	alogp	alogp	PROPN
biomedich-205	166	7	milogp	milogp	PROPN
biomedich-205	166	8	drug	drug	NOUN
biomedich-205	166	9	similarity	similarity	NOUN
biomedich-205	166	10	apomorphine	apomorphine	NOUN
biomedich-205	166	11	6931310	6931310	NUM
biomedich-205	166	12	0.5	0.5	NUM
biomedich-205	166	13	8.7	8.7	NUM
biomedich-205	166	14	2.43	2.43	NUM
biomedich-205	166	15	4.16	4.16	NUM
biomedich-205	166	16	pass	pass	NOUN
biomedich-205	166	17	oxyphencyclimine	oxyphencyclimine	NOUN
biomedich-205	166	18	667690	667690	NUM
biomedich-205	166	19	0.5	0.5	NUM
biomedich-205	166	20	9.9	9.9	NUM
biomedich-205	166	21	3.73	3.73	NUM
biomedich-205	166	22	4.57	4.57	NUM
biomedich-205	166	23	pass	pass	NOUN
biomedich-205	166	24	(	(	PUNCT
biomedich-205	166	25	s)-canadine	s)-canadine	PUNCT
biomedich-205	166	26	21171	21171	NUM
biomedich-205	166	27	0.5	0.5	NUM
biomedich-205	166	28	9.3	9.3	NUM
biomedich-205	166	29	2.67	2.67	NUM
biomedich-205	166	30	3.99	3.99	NUM
biomedich-205	166	31	pass	pass	NOUN
biomedich-205	166	32	naltrexone	naltrexone	PROPN
biomedich-205	166	33	5360515	5360515	NUM
biomedich-205	166	34	0.5	0.5	NUM
biomedich-205	166	35	4.9	4.9	NUM
biomedich-205	166	36	1.11	1.11	NUM
biomedich-205	166	37	2.37	2.37	NUM
biomedich-205	166	38	pass	pass	NOUN
biomedich-205	166	39	oxolinicacid	oxolinicacid	NOUN
biomedich-205	166	40	4628	4628	NUM
biomedich-205	166	41	0.6	0.6	NUM
biomedich-205	166	42	2.5	2.5	NUM
biomedich-205	166	43	2.42	2.42	NUM
biomedich-205	166	44	1.68	1.68	NUM
biomedich-205	166	45	pass	pass	NOUN
biomedich-205	166	46	norfloxacin	norfloxacin	ADV
biomedich-205	166	47	4539	4539	NUM
biomedich-205	166	48	0.5	0.5	NUM
biomedich-205	166	49	-2.8	-2.8	NOUN
biomedich-205	166	50	1.24	1.24	NUM
biomedich-205	166	51	-1.69	-1.69	NOUN
biomedich-205	166	52	pass	pass	VERB
biomedich-205	166	53	(	(	PUNCT
biomedich-205	166	54	r)-canadine	r)-canadine	PUNCT
biomedich-205	166	55	443422	443422	NUM
biomedich-205	166	56	0.4	0.4	NUM
biomedich-205	166	57	9.7	9.7	NUM
biomedich-205	166	58	2.67	2.67	NUM
biomedich-205	166	59	3.99	3.99	NUM
biomedich-205	166	60	pass	pass	NOUN
biomedich-205	166	61	hesperetin	hesperetin	NOUN
biomedich-205	166	62	72281	72281	NUM
biomedich-205	166	63	0.5	0.5	NUM
biomedich-205	166	64	6.1	6.1	NUM
biomedich-205	166	65	3.52	3.52	NUM
biomedich-205	166	66	2.94	2.94	NUM
biomedich-205	166	67	pass	pass	NOUN
biomedich-205	166	68	benzamide	benzamide	NOUN
biomedich-205	166	69	labetalol	labetalol	NOUN
biomedich-205	166	70	134045	134045	NUM
biomedich-205	166	71	0.4	0.4	NUM
biomedich-205	166	72	9.2	9.2	NUM
biomedich-205	166	73	2.11	2.11	NUM
biomedich-205	166	74	3.85	3.85	NUM
biomedich-205	166	75	pass	pass	NOUN
biomedich-205	166	76	benorilate	benorilate	NOUN
biomedich-205	166	77	21102	21102	NUM
biomedich-205	166	78	0.5	0.5	NUM
biomedich-205	166	79	8.3	8.3	NUM
biomedich-205	166	80	3.79	3.79	NUM
biomedich-205	166	81	3.61	3.61	NUM
biomedich-205	166	82	pass	pass	NOUN
biomedich-205	166	83	(	(	PUNCT
biomedich-205	166	84	table	table	NOUN
biomedich-205	166	85	4	4	NUM
biomedich-205	166	86	)	)	PUNCT
biomedich-205	166	87	the	the	DET
biomedich-205	166	88	pubchem	pubchem	NOUN
biomedich-205	166	89	ids	id	NOUN
biomedich-205	166	90	and	and	CCONJ
biomedich-205	166	91	the	the	DET
biomedich-205	166	92	drug	drug	NOUN
biomedich-205	166	93	similarity	similarity	NOUN
biomedich-205	166	94	report	report	NOUN
biomedich-205	166	95	based	base	VERB
biomedich-205	166	96	on	on	ADP
biomedich-205	166	97	the	the	DET
biomedich-205	166	98	“	"	PUNCT
biomedich-205	166	99	lipinski	lipinski	PROPN
biomedich-205	166	100	rule	rule	NOUN
biomedich-205	166	101	”	"	PUNCT
biomedich-205	166	102	is	be	AUX
biomedich-205	166	103	given	give	VERB
biomedich-205	166	104	in	in	ADP
biomedich-205	166	105	detail	detail	NOUN
biomedich-205	166	106	sethuramalingam	sethuramalingam	PROPN
biomedich-205	166	107	et	et	PROPN
biomedich-205	166	108	al	al	PROPN
biomedich-205	166	109	.	.	PROPN
biomedich-205	166	110	–	–	PUNCT
biomedich-205	166	111	identification	identification	NOUN
biomedich-205	166	112	of	of	ADP
biomedich-205	166	113	pcsk9	pcsk9	NOUN
biomedich-205	166	114	inhibitors	inhibitor	VERB
biomedich-205	166	115	125	125	NUM
biomedich-205	166	116	the	the	DET
biomedich-205	166	117	pharmacokinetic	pharmacokinetic	ADJ
biomedich-205	166	118	characteristics	characteristic	NOUN
biomedich-205	166	119	and	and	CCONJ
biomedich-205	166	120	bioavailability	bioavailability	NOUN
biomedich-205	166	121	of	of	ADP
biomedich-205	166	122	the	the	DET
biomedich-205	166	123	medication	medication	NOUN
biomedich-205	166	124	will	will	AUX
biomedich-205	166	125	be	be	AUX
biomedich-205	166	126	evaluated	evaluate	VERB
biomedich-205	166	127	.	.	PUNCT
biomedich-205	167	1	using	use	VERB
biomedich-205	167	2	tools	tool	NOUN
biomedich-205	167	3	,	,	PUNCT
biomedich-205	167	4	“	"	PUNCT
biomedich-205	167	5	molinspiration	molinspiration	NOUN
biomedich-205	167	6	,	,	PUNCT
biomedich-205	167	7	knime	knime	ADJ
biomedich-205	167	8	,	,	PUNCT
biomedich-205	167	9	swissadme	swissadme	NOUN
biomedich-205	167	10	,	,	PUNCT
biomedich-205	167	11	and	and	CCONJ
biomedich-205	167	12	admetsar	admetsar	ADJ
biomedich-205	167	13	,	,	PUNCT
biomedich-205	167	14	computational	computational	ADJ
biomedich-205	167	15	structural	structural	ADJ
biomedich-205	167	16	analysis	analysis	NOUN
biomedich-205	167	17	,	,	PUNCT
biomedich-205	167	18	druglikeness	druglikeness	NOUN
biomedich-205	167	19	,	,	PUNCT
biomedich-205	167	20	adme	adme	VERB
biomedich-205	167	21	characteristics	characteristic	NOUN
biomedich-205	167	22	,	,	PUNCT
biomedich-205	167	23	oral	oral	ADJ
biomedich-205	167	24	bioavailability	bioavailability	NOUN
biomedich-205	167	25	,	,	PUNCT
biomedich-205	167	26	and	and	CCONJ
biomedich-205	167	27	toxicity	toxicity	NOUN
biomedich-205	167	28	profiling	profiling	NOUN
biomedich-205	167	29	”	"	PUNCT
biomedich-205	167	30	have	have	AUX
biomedich-205	167	31	been	be	AUX
biomedich-205	167	32	conducted	conduct	VERB
biomedich-205	167	33	(	(	PUNCT
biomedich-205	167	34	3	3	NUM
biomedich-205	167	35	and	and	CCONJ
biomedich-205	167	36	4	4	NUM
biomedich-205	167	37	tables	table	NOUN
biomedich-205	167	38	)	)	PUNCT
biomedich-205	167	39	.	.	PUNCT
biomedich-205	168	1	using	use	VERB
biomedich-205	168	2	smiles	smile	NOUN
biomedich-205	168	3	codes	code	NOUN
biomedich-205	168	4	,	,	PUNCT
biomedich-205	168	5	the	the	DET
biomedich-205	168	6	pinnacle	pinnacle	PROPN
biomedich-205	168	7	molecules	molecule	NOUN
biomedich-205	168	8	have	have	AUX
biomedich-205	168	9	been	be	AUX
biomedich-205	168	10	re	re	VERB
biomedich-205	168	11	-	-	VERB
biomedich-205	168	12	searched	search	VERB
biomedich-205	168	13	towards	towards	ADP
biomedich-205	168	14	the	the	DET
biomedich-205	168	15	zinc	zinc	NOUN
biomedich-205	168	16	database	database	NOUN
biomedich-205	168	17	,	,	PUNCT
biomedich-205	168	18	molinspiration	molinspiration	NOUN
biomedich-205	168	19	,	,	PUNCT
biomedich-205	168	20	and	and	CCONJ
biomedich-205	168	21	pubchem	pubchem	NOUN
biomedich-205	168	22	,	,	PUNCT
biomedich-205	168	23	and	and	CCONJ
biomedich-205	168	24	that	that	SCONJ
biomedich-205	168	25	they	they	PRON
biomedich-205	168	26	have	have	AUX
biomedich-205	168	27	been	be	AUX
biomedich-205	168	28	all	all	PRON
biomedich-205	168	29	recognized	recognize	VERB
biomedich-205	168	30	as	as	ADP
biomedich-205	168	31	acknowledged	acknowledge	VERB
biomedich-205	168	32	compounds	compound	NOUN
biomedich-205	168	33	,	,	PUNCT
biomedich-205	168	34	a	a	DET
biomedich-205	168	35	number	number	NOUN
biomedich-205	168	36	of	of	ADP
biomedich-205	168	37	plant	plant	NOUN
biomedich-205	168	38	beginning	begin	VERB
biomedich-205	168	39	such	such	ADJ
biomedich-205	168	40	as	as	ADP
biomedich-205	168	41	(	(	PUNCT
biomedich-205	168	42	s)-canadine	s)-canadine	PUNCT
biomedich-205	168	43	and	and	CCONJ
biomedich-205	168	44	hesperetin	hesperetin	NOUN
biomedich-205	168	45	.	.	PUNCT
biomedich-205	169	1	an	an	DET
biomedich-205	169	2	in	in	ADP
biomedich-205	169	3	addition	addition	NOUN
biomedich-205	169	4	antihypertensive	antihypertensive	ADJ
biomedich-205	169	5	agent	agent	NOUN
biomedich-205	169	6	,	,	PUNCT
biomedich-205	169	7	labetalol	labetalol	NOUN
biomedich-205	169	8	,	,	PUNCT
biomedich-205	169	9	turned	turn	VERB
biomedich-205	169	10	into	into	ADP
biomedich-205	169	11	found	find	VERB
biomedich-205	169	12	(	(	PUNCT
biomedich-205	169	13	4	4	NUM
biomedich-205	169	14	table	table	NOUN
biomedich-205	169	15	)	)	PUNCT
biomedich-205	169	16	.	.	PUNCT
biomedich-205	170	1	depending	depend	VERB
biomedich-205	170	2	at	at	ADP
biomedich-205	170	3	the	the	DET
biomedich-205	170	4	diploma	diploma	NOUN
biomedich-205	170	5	of	of	ADP
biomedich-205	170	6	nitrogen	nitrogen	NOUN
biomedich-205	170	7	protonation	protonation	NOUN
biomedich-205	170	8	,	,	PUNCT
biomedich-205	170	9	numerous	numerous	ADJ
biomedich-205	170	10	chemical	chemical	ADJ
biomedich-205	170	11	substances	substance	NOUN
biomedich-205	170	12	containing	contain	VERB
biomedich-205	170	13	nitrogen	nitrogen	NOUN
biomedich-205	170	14	atoms	atom	NOUN
biomedich-205	170	15	may	may	AUX
biomedich-205	170	16	also	also	ADV
biomedich-205	170	17	exist	exist	VERB
biomedich-205	170	18	in	in	ADP
biomedich-205	170	19	lots	lot	NOUN
biomedich-205	170	20	of	of	ADP
biomedich-205	170	21	paperwork	paperwork	NOUN
biomedich-205	170	22	.	.	PUNCT
biomedich-205	171	1	these	these	DET
biomedich-205	171	2	compounds	compound	NOUN
biomedich-205	171	3	incorporate	incorporate	VERB
biomedich-205	171	4	numerous	numerous	ADJ
biomedich-205	171	5	pubchem	pubchem	NOUN
biomedich-205	171	6	codes	code	NOUN
biomedich-205	171	7	,	,	PUNCT
biomedich-205	171	8	distinct	distinct	ADJ
biomedich-205	171	9	smiles	smile	NOUN
biomedich-205	171	10	,	,	PUNCT
biomedich-205	171	11	however	however	ADV
biomedich-205	171	12	are	be	AUX
biomedich-205	171	13	stated	state	VERB
biomedich-205	171	14	as	as	ADP
biomedich-205	171	15	"	"	PUNCT
biomedich-205	171	16	discern	discern	ADJ
biomedich-205	171	17	compounds	compound	NOUN
biomedich-205	171	18	"	"	PUNCT
biomedich-205	171	19	on	on	ADP
biomedich-205	171	20	this	this	DET
biomedich-205	171	21	database	database	NOUN
biomedich-205	171	22	.	.	PUNCT
biomedich-205	172	1	consequently	consequently	ADV
biomedich-205	172	2	,	,	PUNCT
biomedich-205	172	3	it	it	PRON
biomedich-205	172	4	is	be	AUX
biomedich-205	172	5	able	able	ADJ
biomedich-205	172	6	to	to	PART
biomedich-205	172	7	be	be	AUX
biomedich-205	172	8	concluded	conclude	VERB
biomedich-205	172	9	that	that	SCONJ
biomedich-205	172	10	they	they	PRON
biomedich-205	172	11	are	be	AUX
biomedich-205	172	12	the	the	DET
biomedich-205	172	13	equal	equal	ADJ
biomedich-205	172	14	chemical	chemical	NOUN
biomedich-205	172	15	compounds	compound	NOUN
biomedich-205	172	16	that	that	PRON
biomedich-205	172	17	tackle	tackle	VERB
biomedich-205	172	18	numerous	numerous	ADJ
biomedich-205	172	19	paperwork	paperwork	NOUN
biomedich-205	172	20	in	in	ADP
biomedich-205	172	21	accordance	accordance	NOUN
biomedich-205	172	22	at	at	ADP
biomedich-205	172	23	the	the	DET
biomedich-205	172	24	ph	ph	PROPN
biomedich-205	172	25	.	.	PROPN
biomedich-205	172	26	figure	figure	NOUN
biomedich-205	172	27	4	4	NUM
biomedich-205	172	28	depicts	depict	VERB
biomedich-205	172	29	the	the	DET
biomedich-205	172	30	availability	availability	NOUN
biomedich-205	172	31	radars	radar	NOUN
biomedich-205	172	32	of	of	ADP
biomedich-205	172	33	the	the	DET
biomedich-205	172	34	pinnacle	pinnacle	NOUN
biomedich-205	172	35	ten	ten	NUM
biomedich-205	172	36	nominated	nominate	VERB
biomedich-205	172	37	compounds	compound	NOUN
biomedich-205	172	38	.	.	PUNCT
biomedich-205	173	1	figure	figure	NOUN
biomedich-205	173	2	4	4	NUM
biomedich-205	173	3	.	.	PUNCT
biomedich-205	174	1	molecules	molecule	NOUN
biomedich-205	174	2	radar	radar	NOUN
biomedich-205	174	3	chart	chart	NOUN
biomedich-205	174	4	.	.	PUNCT
biomedich-205	175	1	(	(	PUNCT
biomedich-205	175	2	figure	figure	NOUN
biomedich-205	175	3	4	4	NUM
biomedich-205	175	4	)	)	PUNCT
biomedich-205	175	5	–	–	PUNCT
biomedich-205	175	6	this	this	PRON
biomedich-205	175	7	shows	show	VERB
biomedich-205	175	8	the	the	DET
biomedich-205	175	9	molecular	molecular	ADJ
biomedich-205	175	10	radar	radar	NOUN
biomedich-205	175	11	chart	chart	NOUN
biomedich-205	175	12	evaluation	evaluation	NOUN
biomedich-205	175	13	of	of	ADP
biomedich-205	175	14	the	the	DET
biomedich-205	175	15	stability	stability	NOUN
biomedich-205	175	16	of	of	ADP
biomedich-205	175	17	the	the	DET
biomedich-205	175	18	suggested	suggest	VERB
biomedich-205	175	19	proteinligand	proteinligand	NOUN
biomedich-205	175	20	complexes	complex	NOUN
biomedich-205	175	21	upon	upon	SCONJ
biomedich-205	175	22	visual	visual	ADJ
biomedich-205	175	23	inspection	inspection	NOUN
biomedich-205	175	24	with	with	ADP
biomedich-205	175	25	vmd	vmd	PROPN
biomedich-205	175	26	,	,	PUNCT
biomedich-205	175	27	(	(	PUNCT
biomedich-205	175	28	s	s	X
biomedich-205	175	29	)	)	PUNCT
biomedich-205	175	30	canadin	canadin	NOUN
biomedich-205	175	31	,	,	PUNCT
biomedich-205	175	32	hesperetin	hesperetin	NOUN
biomedich-205	175	33	,	,	PUNCT
biomedich-205	175	34	and	and	CCONJ
biomedich-205	175	35	labetalol	labetalol	NOUN
biomedich-205	175	36	produced	produce	VERB
biomedich-205	175	37	a	a	DET
biomedich-205	175	38	strong	strong	ADJ
biomedich-205	175	39	proteinligand	proteinligand	ADJ
biomedich-205	175	40	complex	complex	NOUN
biomedich-205	175	41	throughout	throughout	ADP
biomedich-205	175	42	molecular	molecular	ADJ
biomedich-205	175	43	dynamics	dynamic	NOUN
biomedich-205	175	44	and	and	CCONJ
biomedich-205	175	45	remained	remain	VERB
biomedich-205	175	46	at	at	ADP
biomedich-205	175	47	the	the	DET
biomedich-205	175	48	docking	docking	NOUN
biomedich-205	175	49	targets	target	NOUN
biomedich-205	175	50	for	for	ADP
biomedich-205	175	51	at	at	ADV
biomedich-205	175	52	least	least	ADV
biomedich-205	175	53	10	10	NUM
biomedich-205	175	54	ns	ns	NUM
biomedich-205	175	55	.	.	PUNCT
biomedich-205	176	1	the	the	DET
biomedich-205	176	2	rmsd	rmsd	ADJ
biomedich-205	176	3	value	value	NOUN
biomedich-205	176	4	of	of	ADP
biomedich-205	176	5	the	the	DET
biomedich-205	176	6	heavy	heavy	ADJ
biomedich-205	176	7	atom	atom	NOUN
biomedich-205	176	8	of	of	ADP
biomedich-205	176	9	the	the	DET
biomedich-205	176	10	ligand	ligand	NOUN
biomedich-205	176	11	in	in	ADP
biomedich-205	176	12	the	the	DET
biomedich-205	176	13	10ns	10ns	ADJ
biomedich-205	176	14	lasting	last	VERB
biomedich-205	176	15	simulation	simulation	NOUN
biomedich-205	176	16	of	of	ADP
biomedich-205	176	17	the	the	DET
biomedich-205	176	18	three	three	NUM
biomedich-205	176	19	compounds	compound	NOUN
biomedich-205	176	20	was	be	AUX
biomedich-205	176	21	0.007	0.007	NUM
biomedich-205	176	22	.	.	PUNCT
biomedich-205	177	1	0.13	0.13	NUM
biomedich-205	177	2	0.024	0.024	NUM
biomedich-205	177	3	;	;	PUNCT
biomedich-205	177	4	0.13	0.13	NUM
biomedich-205	177	5	and	and	CCONJ
biomedich-205	177	6	0.035	0.035	NUM
biomedich-205	177	7	(	(	PUNCT
biomedich-205	177	8	mean	mean	NOUN
biomedich-205	177	9	sd	sd	NOUN
biomedich-205	177	10	)	)	PUNCT
biomedich-205	177	11	(	(	PUNCT
biomedich-205	177	12	figure	figure	NOUN
biomedich-205	177	13	5	5	NUM
biomedich-205	177	14	)	)	PUNCT
biomedich-205	177	15	,	,	PUNCT
biomedich-205	177	16	respectively	respectively	ADV
biomedich-205	177	17	,	,	PUNCT
biomedich-205	177	18	suggesting	suggest	VERB
biomedich-205	177	19	that	that	SCONJ
biomedich-205	177	20	the	the	DET
biomedich-205	177	21	position	position	NOUN
biomedich-205	177	22	of	of	ADP
biomedich-205	177	23	the	the	DET
biomedich-205	177	24	ligand	ligand	NOUN
biomedich-205	177	25	changes	change	NOUN
biomedich-205	177	26	only	only	ADV
biomedich-205	177	27	slightly	slightly	ADV
biomedich-205	177	28	.	.	PUNCT
biomedich-205	178	1	the	the	DET
biomedich-205	178	2	value	value	NOUN
biomedich-205	178	3	of	of	ADP
biomedich-205	178	4	(	(	PUNCT
biomedich-205	178	5	s	s	NOUN
biomedich-205	178	6	)	)	PUNCT
biomedich-205	178	7	canadine	canadine	NOUN
biomedich-205	178	8	is	be	AUX
biomedich-205	178	9	0.1	0.1	NUM
biomedich-205	178	10	,	,	PUNCT
biomedich-205	178	11	indicating	indicate	VERB
biomedich-205	178	12	the	the	DET
biomedich-205	178	13	excellent	excellent	ADJ
biomedich-205	178	14	stability	stability	NOUN
biomedich-205	178	15	of	of	ADP
biomedich-205	178	16	this	this	DET
biomedich-205	178	17	compound	compound	NOUN
biomedich-205	178	18	.	.	PUNCT
biomedich-205	179	1	this	this	DET
biomedich-205	179	2	molecule	molecule	NOUN
biomedich-205	179	3	produced	produce	VERB
biomedich-205	179	4	the	the	DET
biomedich-205	179	5	most	most	ADV
biomedich-205	179	6	stable	stable	ADJ
biomedich-205	179	7	(	(	PUNCT
biomedich-205	179	8	s	s	NOUN
biomedich-205	179	9	)	)	PUNCT
biomedich-205	179	10	canadine	canadine	NOUN
biomedich-205	179	11	complex	complex	NOUN
biomedich-205	179	12	in	in	ADP
biomedich-205	179	13	terms	term	NOUN
biomedich-205	179	14	of	of	ADP
biomedich-205	179	15	duration	duration	NOUN
biomedich-205	179	16	and	and	CCONJ
biomedich-205	179	17	molecular	molecular	ADJ
biomedich-205	179	18	dynamics	dynamic	NOUN
biomedich-205	179	19	,	,	PUNCT
biomedich-205	179	20	with	with	ADP
biomedich-205	179	21	the	the	DET
biomedich-205	179	22	lower	low	ADJ
biomedich-205	179	23	rmsd	rmsd	NOUN
biomedich-205	179	24	(	(	PUNCT
biomedich-205	179	25	fig	fig	NOUN
biomedich-205	179	26	.	.	PUNCT
biomedich-205	179	27	5	5	NUM
biomedich-205	179	28	)	)	PUNCT
biomedich-205	179	29	.	.	PUNCT
biomedich-205	180	1	this	this	DET
biomedich-205	180	2	compound	compound	NOUN
biomedich-205	180	3	can	can	AUX
biomedich-205	180	4	be	be	AUX
biomedich-205	180	5	further	far	ADV
biomedich-205	180	6	researched	research	VERB
biomedich-205	180	7	for	for	ADP
biomedich-205	180	8	the	the	DET
biomedich-205	180	9	discovery	discovery	NOUN
biomedich-205	180	10	of	of	ADP
biomedich-205	180	11	new	new	ADJ
biomedich-205	180	12	pcsk9	pcsk9	NOUN
biomedich-205	180	13	inhibitors	inhibitor	NOUN
biomedich-205	180	14	.	.	PUNCT
biomedich-205	181	1	126	126	NUM
biomedich-205	181	2	biology	biology	NOUN
biomedich-205	181	3	,	,	PUNCT
biomedich-205	181	4	medicine	medicine	NOUN
biomedich-205	181	5	,	,	PUNCT
biomedich-205	181	6	&	&	CCONJ
biomedich-205	181	7	natural	natural	ADJ
biomedich-205	181	8	product	product	NOUN
biomedich-205	181	9	chemistry	chemistry	NOUN
biomedich-205	181	10	11	11	NUM
biomedich-205	181	11	(	(	PUNCT
biomedich-205	181	12	2	2	NUM
biomedich-205	181	13	)	)	PUNCT
biomedich-205	181	14	,	,	PUNCT
biomedich-205	181	15	2022	2022	NUM
biomedich-205	181	16	:	:	PUNCT
biomedich-205	181	17	119	119	NUM
biomedich-205	181	18	-	-	SYM
biomedich-205	181	19	131	131	NUM
biomedich-205	181	20	figure	figure	NOUN
biomedich-205	181	21	5	5	NUM
biomedich-205	181	22	.	.	PUNCT
biomedich-205	181	23	rmsd	rmsd	PROPN
biomedich-205	181	24	stimulation	stimulation	NOUN
biomedich-205	181	25	.	.	PUNCT
biomedich-205	182	1	(	(	PUNCT
biomedich-205	182	2	figure	figure	NOUN
biomedich-205	182	3	5	5	NUM
biomedich-205	182	4	)	)	PUNCT
biomedich-205	182	5	–	–	PUNCT
biomedich-205	182	6	it	it	PRON
biomedich-205	182	7	shows	show	VERB
biomedich-205	182	8	the	the	DET
biomedich-205	182	9	rmad	rmad	ADJ
biomedich-205	182	10	stimulation	stimulation	NOUN
biomedich-205	182	11	discussion	discussion	NOUN
biomedich-205	182	12	the	the	DET
biomedich-205	182	13	manufacturing	manufacturing	NOUN
biomedich-205	182	14	of	of	ADP
biomedich-205	182	15	arterial	arterial	ADJ
biomedich-205	182	16	plaques	plaque	NOUN
biomedich-205	182	17	is	be	AUX
biomedich-205	182	18	one	one	NUM
biomedich-205	182	19	of	of	ADP
biomedich-205	182	20	the	the	DET
biomedich-205	182	21	main	main	ADJ
biomedich-205	182	22	reasons	reason	NOUN
biomedich-205	182	23	of	of	ADP
biomedich-205	182	24	atherosclerosis	atherosclerosis	NOUN
biomedich-205	182	25	,	,	PUNCT
biomedich-205	182	26	which	which	PRON
biomedich-205	182	27	in	in	ADP
biomedich-205	182	28	the	the	DET
biomedich-205	182	29	end	end	NOUN
biomedich-205	182	30	outcomes	outcome	NOUN
biomedich-205	182	31	in	in	ADP
biomedich-205	182	32	arterial	arterial	ADJ
biomedich-205	182	33	blockage	blockage	NOUN
biomedich-205	182	34	and	and	CCONJ
biomedich-205	182	35	coronary	coronary	ADJ
biomedich-205	182	36	heart	heart	NOUN
biomedich-205	182	37	attack	attack	NOUN
biomedich-205	182	38	.	.	PUNCT
biomedich-205	183	1	moreover	moreover	ADV
biomedich-205	183	2	,	,	PUNCT
biomedich-205	183	3	better	well	ADJ
biomedich-205	183	4	stages	stage	NOUN
biomedich-205	183	5	of	of	ADP
biomedich-205	183	6	apob	apob	NOUN
biomedich-205	183	7	-	-	PUNCT
biomedich-205	183	8	a	a	DET
biomedich-205	183	9	hundred	hundred	NUM
biomedich-205	183	10	and	and	CCONJ
biomedich-205	183	11	ldl	ldl	NOUN
biomedich-205	183	12	cholesterol	cholesterol	NOUN
biomedich-205	183	13	are	be	AUX
biomedich-205	183	14	without	without	ADP
biomedich-205	183	15	delay	delay	NOUN
biomedich-205	183	16	connected	connect	VERB
biomedich-205	183	17	to	to	ADP
biomedich-205	183	18	atherosclerosis	atherosclerosis	NOUN
biomedich-205	183	19	-	-	PUNCT
biomedich-205	183	20	associated	associate	VERB
biomedich-205	183	21	cvds	cvds	NOUN
biomedich-205	183	22	.	.	PUNCT
biomedich-205	184	1	the	the	DET
biomedich-205	184	2	lipid	lipid	NOUN
biomedich-205	184	3	cycle	cycle	NOUN
biomedich-205	184	4	commonly	commonly	ADV
biomedich-205	184	5	begins	begin	VERB
biomedich-205	184	6	with	with	ADP
biomedich-205	184	7	the	the	DET
biomedich-205	184	8	liver`s	liver`s	PRON
biomedich-205	184	9	launch	launch	NOUN
biomedich-205	184	10	of	of	ADP
biomedich-205	184	11	im	im	NOUN
biomedich-205	184	12	-	-	PUNCT
biomedich-205	184	13	mature	mature	ADJ
biomedich-205	184	14	vldl	vldl	NOUN
biomedich-205	184	15	.	.	PUNCT
biomedich-205	185	1	in	in	ADP
biomedich-205	185	2	addition	addition	NOUN
biomedich-205	185	3	,	,	PUNCT
biomedich-205	185	4	apob	apob	PROPN
biomedich-205	185	5	-	-	PUNCT
biomedich-205	185	6	a	a	DET
biomedich-205	185	7	hundred	hundred	NUM
biomedich-205	185	8	,	,	PUNCT
biomedich-205	185	9	cholesteryl	cholesteryl	NOUN
biomedich-205	185	10	esters	ester	NOUN
biomedich-205	185	11	,	,	PUNCT
biomedich-205	185	12	triglycerides	triglyceride	NOUN
biomedich-205	185	13	,	,	PUNCT
biomedich-205	185	14	and	and	CCONJ
biomedich-205	185	15	ldl	ldl	VERB
biomedich-205	185	16	cholesterol	cholesterol	NOUN
biomedich-205	185	17	are	be	AUX
biomedich-205	185	18	present	present	ADJ
biomedich-205	185	19	.	.	PUNCT
biomedich-205	186	1	vldl	vldl	PROPN
biomedich-205	186	2	broaden	broaden	VERB
biomedich-205	186	3	and	and	CCONJ
biomedich-205	186	4	end	end	VERB
biomedich-205	186	5	up	up	ADP
biomedich-205	186	6	a	a	DET
biomedich-205	186	7	supply	supply	NOUN
biomedich-205	186	8	of	of	ADP
biomedich-205	186	9	electricity	electricity	NOUN
biomedich-205	186	10	in	in	ADP
biomedich-205	186	11	“	"	PUNCT
biomedich-205	186	12	adipose	adipose	ADJ
biomedich-205	186	13	tissues	tissue	NOUN
biomedich-205	186	14	,	,	PUNCT
biomedich-205	186	15	skeletal	skeletal	ADJ
biomedich-205	186	16	and	and	CCONJ
biomedich-205	186	17	cardiac	cardiac	ADJ
biomedich-205	186	18	muscular	muscular	ADJ
biomedich-205	186	19	tissues	tissue	NOUN
biomedich-205	186	20	”	"	PUNCT
biomedich-205	186	21	all	all	PRON
biomedich-205	186	22	through	through	ADP
biomedich-205	186	23	movement	movement	NOUN
biomedich-205	186	24	withinside	withinside	ADP
biomedich-205	186	25	the	the	DET
biomedich-205	186	26	blood	blood	NOUN
biomedich-205	186	27	(	(	PUNCT
biomedich-205	186	28	chaudhary	chaudhary	PROPN
biomedich-205	186	29	et	et	PROPN
biomedich-205	186	30	al	al	PROPN
biomedich-205	186	31	.	.	PROPN
biomedich-205	186	32	,	,	PUNCT
biomedich-205	186	33	2017	2017	NUM
biomedich-205	186	34	)	)	PUNCT
biomedich-205	186	35	.	.	PUNCT
biomedich-205	187	1	one	one	NUM
biomedich-205	187	2	of	of	ADP
biomedich-205	187	3	the	the	DET
biomedich-205	187	4	jobs	job	NOUN
biomedich-205	187	5	of	of	ADP
biomedich-205	187	6	vldl	vldl	NOUN
biomedich-205	187	7	is	be	AUX
biomedich-205	187	8	the	the	DET
biomedich-205	187	9	trade	trade	NOUN
biomedich-205	187	10	and	and	CCONJ
biomedich-205	187	11	elimination	elimination	NOUN
biomedich-205	187	12	of	of	ADP
biomedich-205	187	13	triglycerides	triglyceride	NOUN
biomedich-205	187	14	,	,	PUNCT
biomedich-205	187	15	which	which	PRON
biomedich-205	187	16	ends	end	VERB
biomedich-205	187	17	up	up	ADP
biomedich-205	187	18	withinside	withinside	ADP
biomedich-205	187	19	the	the	DET
biomedich-205	187	20	conversion	conversion	NOUN
biomedich-205	187	21	of	of	ADP
biomedich-205	187	22	vldl	vldl	NOUN
biomedich-205	187	23	into	into	ADP
biomedich-205	187	24	intermediate	intermediate	ADJ
biomedich-205	187	25	-	-	PUNCT
biomedich-205	187	26	density	density	NOUN
biomedich-205	187	27	lipoproteins	lipoprotein	NOUN
biomedich-205	187	28	(	(	PUNCT
biomedich-205	187	29	idl	idl	NOUN
biomedich-205	187	30	)	)	PUNCT
biomedich-205	187	31	(	(	PUNCT
biomedich-205	187	32	shelness	shelness	NOUN
biomedich-205	187	33	&	&	CCONJ
biomedich-205	187	34	sellers	seller	NOUN
biomedich-205	187	35	,	,	PUNCT
biomedich-205	187	36	2001	2001	NUM
biomedich-205	187	37	)	)	PUNCT
biomedich-205	187	38	.	.	PUNCT
biomedich-205	188	1	some	some	PRON
biomedich-205	188	2	of	of	ADP
biomedich-205	188	3	those	those	DET
biomedich-205	188	4	idl	idl	NOUN
biomedich-205	188	5	can	can	AUX
biomedich-205	188	6	be	be	AUX
biomedich-205	188	7	removed	remove	VERB
biomedich-205	188	8	through	through	ADP
biomedich-205	188	9	the	the	DET
biomedich-205	188	10	liver	liver	NOUN
biomedich-205	188	11	all	all	ADV
biomedich-205	188	12	through	through	ADP
biomedich-205	188	13	endocytosis	endocytosis	NOUN
biomedich-205	188	14	,	,	PUNCT
biomedich-205	188	15	whilst	whilst	SCONJ
biomedich-205	188	16	idl	idl	NOUN
biomedich-205	188	17	with	with	ADP
biomedich-205	188	18	a	a	DET
biomedich-205	188	19	more	more	ADV
biomedich-205	188	20	ldl	ldl	NOUN
biomedich-205	188	21	cholesterol	cholesterol	NOUN
biomedich-205	188	22	content	content	NOUN
biomedich-205	188	23	material	material	NOUN
biomedich-205	188	24	are	be	AUX
biomedich-205	188	25	transformed	transform	VERB
biomedich-205	188	26	to	to	PART
biomedich-205	188	27	ldl	ldl	VERB
biomedich-205	188	28	,	,	PUNCT
biomedich-205	188	29	which	which	PRON
biomedich-205	188	30	additionally	additionally	ADV
biomedich-205	188	31	consists	consist	VERB
biomedich-205	188	32	of	of	ADP
biomedich-205	188	33	apob	apob	NOUN
biomedich-205	188	34	-	-	PUNCT
biomedich-205	188	35	a	a	PRON
biomedich-205	188	36	hundred	hundred	NUM
biomedich-205	188	37	.	.	PUNCT
biomedich-205	189	1	this	this	DET
biomedich-205	189	2	apob	apob	PROPN
biomedich-205	189	3	-	-	PUNCT
biomedich-205	189	4	a	a	PRON
biomedich-205	189	5	hundred	hundred	NUM
biomedich-205	189	6	attaches	attach	VERB
biomedich-205	189	7	to	to	PART
biomedich-205	189	8	ldlr	ldlr	VERB
biomedich-205	189	9	at	at	ADP
biomedich-205	189	10	its	its	PRON
biomedich-205	189	11	n	n	CCONJ
biomedich-205	189	12	-	-	PUNCT
biomedich-205	189	13	terminal	terminal	ADJ
biomedich-205	189	14	area	area	NOUN
biomedich-205	189	15	after	after	SCONJ
biomedich-205	189	16	which	which	PRON
biomedich-205	189	17	passes	pass	VERB
biomedich-205	189	18	via	via	ADP
biomedich-205	189	19	the	the	DET
biomedich-205	189	20	acidic	acidic	ADJ
biomedich-205	189	21	endosome	endosome	NOUN
biomedich-205	189	22	via	via	ADP
biomedich-205	189	23	endocytosis	endocytosis	NOUN
biomedich-205	189	24	.	.	PUNCT
biomedich-205	190	1	ldlr	ldlr	PROPN
biomedich-205	190	2	in	in	ADP
biomedich-205	190	3	the	the	DET
biomedich-205	190	4	end	end	NOUN
biomedich-205	190	5	breaks	break	NOUN
biomedich-205	190	6	from	from	ADP
biomedich-205	190	7	ldl	ldl	NOUN
biomedich-205	190	8	and	and	CCONJ
biomedich-205	190	9	is	be	AUX
biomedich-205	190	10	reintroduced	reintroduce	VERB
biomedich-205	190	11	into	into	ADP
biomedich-205	190	12	the	the	DET
biomedich-205	190	13	mobileular	mobileular	ADJ
biomedich-205	190	14	membrane	membrane	NOUN
biomedich-205	190	15	(	(	PUNCT
biomedich-205	190	16	ding	ding	NOUN
biomedich-205	190	17	et	et	PROPN
biomedich-205	190	18	al	al	PROPN
biomedich-205	190	19	.	.	PROPN
biomedich-205	190	20	,	,	PUNCT
biomedich-205	190	21	2015	2015	NUM
biomedich-205	190	22	)	)	PUNCT
biomedich-205	190	23	.	.	PUNCT
biomedich-205	191	1	at	at	ADP
biomedich-205	191	2	an	an	DET
biomedich-205	191	3	acidic	acidic	ADJ
biomedich-205	191	4	ph	ph	VERB
biomedich-205	191	5	,	,	PUNCT
biomedich-205	191	6	structural	structural	ADJ
biomedich-205	191	7	changes	change	NOUN
biomedich-205	191	8	in	in	ADP
biomedich-205	191	9	ldlr	ldlr	ADJ
biomedich-205	191	10	might	might	AUX
biomedich-205	191	11	also	also	ADV
biomedich-205	191	12	additionally	additionally	ADV
biomedich-205	191	13	decorate	decorate	VERB
biomedich-205	191	14	pcsk9	pcsk9	PROPN
biomedich-205	191	15	's	's	PART
biomedich-205	191	16	affinity	affinity	NOUN
biomedich-205	191	17	for	for	ADP
biomedich-205	191	18	ldlr	ldlr	ADJ
biomedich-205	191	19	relative	relative	ADJ
biomedich-205	191	20	to	to	ADP
biomedich-205	191	21	ldl(horton	ldl(horton	PROPN
biomedich-205	191	22	et	et	PROPN
biomedich-205	191	23	al	al	PROPN
biomedich-205	191	24	.	.	PROPN
biomedich-205	191	25	,	,	PUNCT
biomedich-205	191	26	2009	2009	NUM
biomedich-205	191	27	)	)	PUNCT
biomedich-205	191	28	.	.	PUNCT
biomedich-205	192	1	although	although	SCONJ
biomedich-205	192	2	mutations	mutation	NOUN
biomedich-205	192	3	might	might	AUX
biomedich-205	192	4	also	also	ADV
biomedich-205	192	5	additionally	additionally	ADV
biomedich-205	192	6	dispose	dispose	ADJ
biomedich-205	192	7	of	of	ADP
biomedich-205	192	8	the	the	DET
biomedich-205	192	9	catalytic	catalytic	ADJ
biomedich-205	192	10	hobby	hobby	NOUN
biomedich-205	192	11	of	of	ADP
biomedich-205	192	12	pcsk9	pcsk9	PROPN
biomedich-205	192	13	,	,	PUNCT
biomedich-205	192	14	they	they	PRON
biomedich-205	192	15	do	do	AUX
biomedich-205	192	16	now	now	ADV
biomedich-205	192	17	no	no	ADV
biomedich-205	192	18	longer	long	ADV
biomedich-205	192	19	have	have	VERB
biomedich-205	192	20	an	an	DET
biomedich-205	192	21	effect	effect	NOUN
biomedich-205	192	22	on	on	ADP
biomedich-205	192	23	its	its	PRON
biomedich-205	192	24	cappotential	cappotential	NOUN
biomedich-205	192	25	to	to	PART
biomedich-205	192	26	bind	bind	VERB
biomedich-205	192	27	to	to	ADP
biomedich-205	192	28	ldlr	ldlr	NOUN
biomedich-205	192	29	.	.	PUNCT
biomedich-205	193	1	a	a	DET
biomedich-205	193	2	stoppage	stoppage	NOUN
biomedich-205	193	3	withinside	withinside	ADP
biomedich-205	193	4	the	the	DET
biomedich-205	193	5	protein	protein	NOUN
biomedich-205	193	6	's	's	PART
biomedich-205	193	7	manufacturing	manufacturing	NOUN
biomedich-205	193	8	might	might	AUX
biomedich-205	193	9	also	also	ADV
biomedich-205	193	10	additionally	additionally	ADV
biomedich-205	193	11	bring	bring	VERB
biomedich-205	193	12	about	about	ADP
biomedich-205	193	13	blockading	blockade	VERB
biomedich-205	193	14	its	its	PRON
biomedich-205	193	15	binding	binding	NOUN
biomedich-205	193	16	to	to	AUX
biomedich-205	193	17	ldlr	ldlr	ADJ
biomedich-205	193	18	.	.	PUNCT
biomedich-205	194	1	pcsk9	pcsk9	PROPN
biomedich-205	194	2	mrna	mrna	PROPN
biomedich-205	194	3	degradation	degradation	NOUN
biomedich-205	194	4	might	might	AUX
biomedich-205	194	5	also	also	ADV
biomedich-205	194	6	additionally	additionally	ADV
biomedich-205	194	7	in	in	ADP
biomedich-205	194	8	the	the	DET
biomedich-205	194	9	end	end	NOUN
biomedich-205	194	10	hinder	hinder	VERB
biomedich-205	194	11	its	its	PRON
biomedich-205	194	12	reference	reference	NOUN
biomedich-205	194	13	to	to	ADP
biomedich-205	194	14	ldlr	ldlr	PROPN
biomedich-205	194	15	,	,	PUNCT
biomedich-205	194	16	or	or	CCONJ
biomedich-205	194	17	a	a	DET
biomedich-205	194	18	tiny	tiny	ADJ
biomedich-205	194	19	drug	drug	NOUN
biomedich-205	194	20	meant	mean	VERB
biomedich-205	194	21	to	to	PART
biomedich-205	194	22	save	save	VERB
biomedich-205	194	23	you	you	PRON
biomedich-205	194	24	this	this	DET
biomedich-205	194	25	courting	courting	NOUN
biomedich-205	194	26	also	also	ADV
biomedich-205	194	27	can	can	AUX
biomedich-205	194	28	do	do	VERB
biomedich-205	194	29	so	so	ADV
biomedich-205	194	30	(	(	PUNCT
biomedich-205	194	31	mcnutt	mcnutt	PROPN
biomedich-205	194	32	et	et	PROPN
biomedich-205	194	33	al	al	PROPN
biomedich-205	194	34	.	.	PROPN
biomedich-205	194	35	,	,	PUNCT
biomedich-205	194	36	2007	2007	NUM
biomedich-205	194	37	)	)	PUNCT
biomedich-205	194	38	.	.	PUNCT
biomedich-205	195	1	atherosclerosis	atherosclerosis	NOUN
biomedich-205	195	2	is	be	AUX
biomedich-205	195	3	as	as	ADP
biomedich-205	195	4	a	a	DET
biomedich-205	195	5	result	result	NOUN
biomedich-205	195	6	of	of	ADP
biomedich-205	195	7	the	the	DET
biomedich-205	195	8	interplay	interplay	NOUN
biomedich-205	195	9	among	among	ADP
biomedich-205	195	10	pcsk9	pcsk9	PROPN
biomedich-205	195	11	and	and	CCONJ
biomedich-205	195	12	ldlr	ldlr	PROPN
biomedich-205	195	13	(	(	PUNCT
biomedich-205	195	14	egf	egf	PROPN
biomedich-205	195	15	-	-	PUNCT
biomedich-205	195	16	a	a	DET
biomedich-205	195	17	area	area	NOUN
biomedich-205	195	18	or	or	CCONJ
biomedich-205	195	19	epidermal	epidermal	ADJ
biomedich-205	195	20	boom	boom	NOUN
biomedich-205	195	21	factor	factor	NOUN
biomedich-205	195	22	-	-	PUNCT
biomedich-205	195	23	like	like	ADJ
biomedich-205	195	24	repeats	repeat	NOUN
biomedich-205	195	25	)	)	PUNCT
biomedich-205	195	26	,	,	PUNCT
biomedich-205	195	27	which	which	PRON
biomedich-205	195	28	inhibits	inhibit	VERB
biomedich-205	195	29	the	the	DET
biomedich-205	195	30	endocytosis	endocytosis	NOUN
biomedich-205	195	31	of	of	ADP
biomedich-205	195	32	ldl	ldl	NOUN
biomedich-205	195	33	.	.	PUNCT
biomedich-205	196	1	the	the	DET
biomedich-205	196	2	connection	connection	NOUN
biomedich-205	196	3	among	among	ADP
biomedich-205	196	4	pcsk9	pcsk9	PROPN
biomedich-205	196	5	and	and	CCONJ
biomedich-205	196	6	ldlr	ldlr	PROPN
biomedich-205	196	7	can	can	AUX
biomedich-205	196	8	be	be	AUX
biomedich-205	196	9	blocked	block	VERB
biomedich-205	196	10	to	to	PART
biomedich-205	196	11	halt	halt	VERB
biomedich-205	196	12	the	the	DET
biomedich-205	196	13	buildup	buildup	NOUN
biomedich-205	196	14	of	of	ADP
biomedich-205	196	15	ldl	ldl	NOUN
biomedich-205	196	16	.	.	PUNCT
biomedich-205	197	1	pcsk9	pcsk9	PROPN
biomedich-205	197	2	is	be	AUX
biomedich-205	197	3	produced	produce	VERB
biomedich-205	197	4	withinside	withinside	ADP
biomedich-205	197	5	the	the	DET
biomedich-205	197	6	er	er	INTJ
biomedich-205	197	7	and	and	CCONJ
biomedich-205	197	8	transferred	transfer	VERB
biomedich-205	197	9	to	to	ADP
biomedich-205	197	10	the	the	DET
biomedich-205	197	11	plasma	plasma	NOUN
biomedich-205	197	12	membrane	membrane	NOUN
biomedich-205	197	13	to	to	PART
biomedich-205	197	14	be	be	AUX
biomedich-205	197	15	able	able	ADJ
biomedich-205	197	16	to	to	PART
biomedich-205	197	17	have	have	VERB
biomedich-205	197	18	interaction	interaction	NOUN
biomedich-205	197	19	with	with	ADP
biomedich-205	197	20	ldlr	ldlr	ADJ
biomedich-205	197	21	.	.	PUNCT
biomedich-205	198	1	protein	protein	NOUN
biomedich-205	198	2	-	-	PUNCT
biomedich-205	198	3	protein	protein	NOUN
biomedich-205	198	4	interactions	interaction	NOUN
biomedich-205	198	5	govern	govern	VERB
biomedich-205	198	6	a	a	DET
biomedich-205	198	7	extensive	extensive	ADJ
biomedich-205	198	8	quantity	quantity	NOUN
biomedich-205	198	9	of	of	ADP
biomedich-205	198	10	organic	organic	ADJ
biomedich-205	198	11	activities	activity	NOUN
biomedich-205	198	12	.	.	PUNCT
biomedich-205	199	1	the	the	DET
biomedich-205	199	2	law	law	NOUN
biomedich-205	199	3	of	of	ADP
biomedich-205	199	4	those	those	DET
biomedich-205	199	5	interactions	interaction	NOUN
biomedich-205	199	6	is	be	AUX
biomedich-205	199	7	a	a	DET
biomedich-205	199	8	famous	famous	ADJ
biomedich-205	199	9	and	and	CCONJ
biomedich-205	199	10	potential	potential	ADJ
biomedich-205	199	11	drug	drug	NOUN
biomedich-205	199	12	improvement	improvement	NOUN
biomedich-205	199	13	pathway	pathway	NOUN
biomedich-205	199	14	.	.	PUNCT
biomedich-205	200	1	to	to	PART
biomedich-205	200	2	save	save	VERB
biomedich-205	200	3	you	you	PRON
biomedich-205	200	4	the	the	DET
biomedich-205	200	5	egf	egf	PROPN
biomedich-205	200	6	area	area	NOUN
biomedich-205	200	7	of	of	ADP
biomedich-205	200	8	ldlr	ldlr	PROPN
biomedich-205	200	9	from	from	ADP
biomedich-205	200	10	interacting	interact	VERB
biomedich-205	200	11	with	with	ADP
biomedich-205	200	12	pcsk9	pcsk9	PROPN
biomedich-205	200	13	,	,	PUNCT
biomedich-205	200	14	it	it	PRON
biomedich-205	200	15	's	be	AUX
biomedich-205	200	16	far	far	ADV
biomedich-205	200	17	important	important	ADJ
biomedich-205	200	18	to	to	PART
biomedich-205	200	19	perceive	perceive	VERB
biomedich-205	200	20	the	the	DET
biomedich-205	200	21	interplay	interplay	NOUN
biomedich-205	200	22	's	's	PART
biomedich-205	200	23	goal	goal	NOUN
biomedich-205	200	24	location	location	NOUN
biomedich-205	200	25	.	.	PUNCT
biomedich-205	201	1	it	it	PRON
biomedich-205	201	2	is	be	AUX
biomedich-205	201	3	acknowledged	acknowledge	VERB
biomedich-205	201	4	that	that	SCONJ
biomedich-205	201	5	antihypertensive	antihypertensive	ADJ
biomedich-205	201	6	medications	medication	NOUN
biomedich-205	201	7	,	,	PUNCT
biomedich-205	201	8	specifically	specifically	ADV
biomedich-205	201	9	ace	ace	VERB
biomedich-205	201	10	inhibitors	inhibitor	NOUN
biomedich-205	201	11	,	,	PUNCT
biomedich-205	201	12	have	have	VERB
biomedich-205	201	13	a	a	DET
biomedich-205	201	14	essential	essential	ADJ
biomedich-205	201	15	position	position	NOUN
biomedich-205	201	16	in	in	ADP
biomedich-205	201	17	atherosclerosis	atherosclerosis	NOUN
biomedich-205	201	18	(	(	PUNCT
biomedich-205	201	19	pitt	pitt	PROPN
biomedich-205	201	20	,	,	PUNCT
biomedich-205	201	21	1995	1995	NUM
biomedich-205	201	22	)	)	PUNCT
biomedich-205	201	23	.	.	PUNCT
biomedich-205	202	1	acei	acei	PROPN
biomedich-205	202	2	are	be	AUX
biomedich-205	202	3	putative	putative	ADJ
biomedich-205	202	4	plaque	plaque	NOUN
biomedich-205	202	5	formation	formation	NOUN
biomedich-205	202	6	inhibitors	inhibitor	NOUN
biomedich-205	202	7	(	(	PUNCT
biomedich-205	202	8	ferrari	ferrari	PROPN
biomedich-205	202	9	et	et	PROPN
biomedich-205	202	10	al	al	PROPN
biomedich-205	202	11	.	.	PROPN
biomedich-205	202	12	,	,	PUNCT
biomedich-205	202	13	2010	2010	NUM
biomedich-205	202	14	)	)	PUNCT
biomedich-205	202	15	.	.	PUNCT
biomedich-205	203	1	experimental	experimental	ADJ
biomedich-205	203	2	,	,	PUNCT
biomedich-205	203	3	epidemiological	epidemiological	ADJ
biomedich-205	203	4	,	,	PUNCT
biomedich-205	203	5	and	and	CCONJ
biomedich-205	203	6	scientific	scientific	ADJ
biomedich-205	203	7	research	research	NOUN
biomedich-205	203	8	have	have	AUX
biomedich-205	203	9	proven	prove	VERB
biomedich-205	203	10	that	that	PRON
biomedich-205	203	11	ace	ace	VERB
biomedich-205	203	12	inhibitors	inhibitor	NOUN
biomedich-205	203	13	decorate	decorate	VERB
biomedich-205	203	14	arterial	arterial	ADJ
biomedich-205	203	15	endothelial	endothelial	ADJ
biomedich-205	203	16	feature	feature	NOUN
biomedich-205	203	17	and	and	CCONJ
biomedich-205	203	18	,	,	PUNCT
biomedich-205	203	19	thus	thus	ADV
biomedich-205	203	20	,	,	PUNCT
biomedich-205	203	21	lower	low	ADJ
biomedich-205	203	22	the	the	DET
biomedich-205	203	23	improvement	improvement	NOUN
biomedich-205	203	24	of	of	ADP
biomedich-205	203	25	atherosclerosis	atherosclerosis	NOUN
biomedich-205	203	26	(	(	PUNCT
biomedich-205	203	27	lonn	lonn	PROPN
biomedich-205	203	28	,	,	PUNCT
biomedich-205	203	29	2001	2001	NUM
biomedich-205	203	30	)	)	PUNCT
biomedich-205	203	31	.	.	PUNCT
biomedich-205	204	1	it	it	PRON
biomedich-205	204	2	has	have	AUX
biomedich-205	204	3	been	be	AUX
biomedich-205	204	4	proven	prove	VERB
biomedich-205	204	5	that	that	SCONJ
biomedich-205	204	6	they	they	PRON
biomedich-205	204	7	lower	lower	VERB
biomedich-205	204	8	erythropoietin	erythropoietin	NOUN
biomedich-205	204	9	(	(	PUNCT
biomedich-205	204	10	epo	epo	NOUN
biomedich-205	204	11	)	)	PUNCT
biomedich-205	204	12	stages	stage	NOUN
biomedich-205	204	13	and	and	CCONJ
biomedich-205	204	14	hematocrit	hematocrit	NOUN
biomedich-205	204	15	.	.	PUNCT
biomedich-205	205	1	acei	acei	NOUN
biomedich-205	205	2	might	might	AUX
biomedich-205	205	3	also	also	ADV
biomedich-205	205	4	additionally	additionally	ADV
biomedich-205	205	5	modulate	modulate	VERB
biomedich-205	205	6	a	a	DET
biomedich-205	205	7	whole	whole	ADJ
biomedich-205	205	8	lot	lot	NOUN
biomedich-205	205	9	of	of	ADP
biomedich-205	205	10	bioactive	bioactive	ADJ
biomedich-205	205	11	peptides	peptide	NOUN
biomedich-205	205	12	,	,	PUNCT
biomedich-205	205	13	along	along	ADP
biomedich-205	205	14	with	with	ADP
biomedich-205	205	15	angiotensin	angiotensin	NOUN
biomedich-205	205	16	1–7	1–7	NUM
biomedich-205	205	17	and	and	CCONJ
biomedich-205	205	18	substance	substance	NOUN
biomedich-205	205	19	p.	p.	NOUN
biomedich-205	205	20	in	in	ADP
biomedich-205	205	21	hematopoiesis	hematopoiesis	NOUN
biomedich-205	205	22	,	,	PUNCT
biomedich-205	205	23	numerous	numerous	ADJ
biomedich-205	205	24	sethuramalingam	sethuramalingam	PROPN
biomedich-205	205	25	et	et	PROPN
biomedich-205	205	26	al	al	PROPN
biomedich-205	205	27	.	.	PROPN
biomedich-205	205	28	–	–	PUNCT
biomedich-205	205	29	identification	identification	NOUN
biomedich-205	205	30	of	of	ADP
biomedich-205	205	31	pcsk9	pcsk9	NOUN
biomedich-205	205	32	inhibitors	inhibitor	VERB
biomedich-205	205	33	127	127	NUM
biomedich-205	205	34	peptides	peptide	NOUN
biomedich-205	205	35	had	have	AUX
biomedich-205	205	36	been	be	AUX
biomedich-205	205	37	located	locate	VERB
biomedich-205	205	38	to	to	PART
biomedich-205	205	39	have	have	VERB
biomedich-205	205	40	a	a	DET
biomedich-205	205	41	position	position	NOUN
biomedich-205	205	42	.	.	PUNCT
biomedich-205	206	1	reducing	reduce	VERB
biomedich-205	206	2	the	the	DET
biomedich-205	206	3	quantity	quantity	NOUN
biomedich-205	206	4	of	of	ADP
biomedich-205	206	5	angiotensin	angiotensin	NOUN
biomedich-205	206	6	ii	ii	PROPN
biomedich-205	206	7	might	might	AUX
biomedich-205	206	8	also	also	ADV
biomedich-205	206	9	additionally	additionally	ADV
biomedich-205	206	10	restrict	restrict	VERB
biomedich-205	206	11	erythropoiesis	erythropoiesis	NOUN
biomedich-205	206	12	.	.	PUNCT
biomedich-205	207	1	acei	acei	PROPN
biomedich-205	207	2	additionally	additionally	ADV
biomedich-205	207	3	have	have	VERB
biomedich-205	207	4	an	an	DET
biomedich-205	207	5	effect	effect	NOUN
biomedich-205	207	6	on	on	ADP
biomedich-205	207	7	the	the	DET
biomedich-205	207	8	renin	renin	ADJ
biomedich-205	207	9	-	-	PUNCT
biomedich-205	207	10	angiotensin	angiotensin	NOUN
biomedich-205	207	11	system	system	NOUN
biomedich-205	207	12	(	(	PUNCT
biomedich-205	207	13	younas	youna	NOUN
biomedich-205	207	14	et	et	PROPN
biomedich-205	207	15	al	al	PROPN
biomedich-205	207	16	.	.	PROPN
biomedich-205	207	17	,	,	PUNCT
biomedich-205	207	18	2017	2017	NUM
biomedich-205	207	19	)	)	PUNCT
biomedich-205	207	20	.	.	PUNCT
biomedich-205	208	1	several	several	ADJ
biomedich-205	208	2	ace	ace	NOUN
biomedich-205	208	3	inhibitors	inhibitor	NOUN
biomedich-205	208	4	,	,	PUNCT
biomedich-205	208	5	along	along	ADP
biomedich-205	208	6	with	with	ADP
biomedich-205	208	7	“	"	PUNCT
biomedich-205	208	8	captopril	captopril	NOUN
biomedich-205	208	9	,	,	PUNCT
biomedich-205	208	10	zofenopril	zofenopril	NOUN
biomedich-205	208	11	,	,	PUNCT
biomedich-205	208	12	enalapril	enalapril	NOUN
biomedich-205	208	13	,	,	PUNCT
biomedich-205	208	14	ramipril	ramipril	NOUN
biomedich-205	208	15	,	,	PUNCT
biomedich-205	208	16	quinapril	quinapril	NOUN
biomedich-205	208	17	,	,	PUNCT
biomedich-205	208	18	perindopril	perindopril	ADJ
biomedich-205	208	19	,	,	PUNCT
biomedich-205	208	20	lisinopril	lisinopril	PROPN
biomedich-205	208	21	,	,	PUNCT
biomedich-205	208	22	benazepril	benazepril	ADJ
biomedich-205	208	23	,	,	PUNCT
biomedich-205	208	24	fosinopril	fosinopril	ADJ
biomedich-205	208	25	,	,	PUNCT
biomedich-205	208	26	cilazapril	cilazapril	NOUN
biomedich-205	208	27	,	,	PUNCT
biomedich-205	208	28	moexipril	moexipril	NOUN
biomedich-205	208	29	,	,	PUNCT
biomedich-205	208	30	trandolapril	trandolapril	PROPN
biomedich-205	208	31	,	,	PUNCT
biomedich-205	208	32	allicin	allicin	NOUN
biomedich-205	208	33	,	,	PUNCT
biomedich-205	208	34	and	and	CCONJ
biomedich-205	208	35	teprotide	teprotide	ADJ
biomedich-205	208	36	”	"	PUNCT
biomedich-205	208	37	,	,	PUNCT
biomedich-205	208	38	had	have	AUX
biomedich-205	208	39	been	be	AUX
biomedich-205	208	40	used	use	VERB
biomedich-205	208	41	on	on	ADP
biomedich-205	208	42	this	this	DET
biomedich-205	208	43	study	study	NOUN
biomedich-205	208	44	.	.	PUNCT
biomedich-205	209	1	captopril	captopril	NOUN
biomedich-205	209	2	decreases	decrease	VERB
biomedich-205	209	3	ldl	ldl	NOUN
biomedich-205	209	4	oxidation	oxidation	NOUN
biomedich-205	209	5	,	,	PUNCT
biomedich-205	209	6	which	which	PRON
biomedich-205	209	7	is	be	AUX
biomedich-205	209	8	understood	understand	VERB
biomedich-205	209	9	to	to	PART
biomedich-205	209	10	make	make	VERB
biomedich-205	209	11	contributions	contribution	NOUN
biomedich-205	209	12	to	to	ADP
biomedich-205	209	13	the	the	DET
biomedich-205	209	14	improvement	improvement	NOUN
biomedich-205	209	15	of	of	ADP
biomedich-205	209	16	atherosclerosis	atherosclerosis	NOUN
biomedich-205	209	17	(	(	PUNCT
biomedich-205	209	18	k.r	k.r	PROPN
biomedich-205	209	19	.	.	PROPN
biomedich-205	209	20	et	et	PROPN
biomedich-205	209	21	al	al	PROPN
biomedich-205	209	22	.	.	PROPN
biomedich-205	209	23	,	,	PUNCT
biomedich-205	209	24	2014	2014	NUM
biomedich-205	209	25	)	)	PUNCT
biomedich-205	209	26	.	.	PUNCT
biomedich-205	210	1	zofenopril	zofenopril	NOUN
biomedich-205	210	2	and	and	CCONJ
biomedich-205	210	3	enala	enala	PROPN
biomedich-205	210	4	prilare	prilare	PROPN
biomedich-205	210	5	acei	acei	PROPN
biomedich-205	210	6	which	which	PRON
biomedich-205	210	7	can	can	AUX
biomedich-205	210	8	lessen	lessen	VERB
biomedich-205	210	9	vascular	vascular	ADJ
biomedich-205	210	10	harm	harm	NOUN
biomedich-205	210	11	and	and	CCONJ
biomedich-205	210	12	enhance	enhance	VERB
biomedich-205	210	13	endothelial	endothelial	ADJ
biomedich-205	210	14	progenitor	progenitor	NOUN
biomedich-205	210	15	mobileular	mobileular	ADJ
biomedich-205	210	16	movement	movement	NOUN
biomedich-205	210	17	.	.	PUNCT
biomedich-205	211	1	they	they	PRON
biomedich-205	211	2	inhibit	inhibit	VERB
biomedich-205	211	3	endothelial	endothelial	ADJ
biomedich-205	211	4	harm	harm	NOUN
biomedich-205	211	5	and	and	CCONJ
biomedich-205	211	6	the	the	DET
biomedich-205	211	7	improvement	improvement	NOUN
biomedich-205	211	8	of	of	ADP
biomedich-205	211	9	atherosclerosis	atherosclerosis	NOUN
biomedich-205	211	10	(	(	PUNCT
biomedich-205	211	11	pines	pine	NOUN
biomedich-205	211	12	&	&	CCONJ
biomedich-205	211	13	fisman	fisman	NOUN
biomedich-205	211	14	,	,	PUNCT
biomedich-205	211	15	2003	2003	NUM
biomedich-205	211	16	)	)	PUNCT
biomedich-205	211	17	.	.	PUNCT
biomedich-205	212	1	arterial	arterial	ADJ
biomedich-205	212	2	plaque	plaque	NOUN
biomedich-205	212	3	formation	formation	NOUN
biomedich-205	212	4	is	be	AUX
biomedich-205	212	5	one	one	NUM
biomedich-205	212	6	of	of	ADP
biomedich-205	212	7	the	the	DET
biomedich-205	212	8	leading	lead	VERB
biomedich-205	212	9	causes	cause	NOUN
biomedich-205	212	10	of	of	ADP
biomedich-205	212	11	atherosclerosis	atherosclerosis	NOUN
biomedich-205	212	12	and	and	CCONJ
biomedich-205	212	13	ultimately	ultimately	ADV
biomedich-205	212	14	causes	cause	VERB
biomedich-205	212	15	arterial	arterial	ADJ
biomedich-205	212	16	occlusion	occlusion	NOUN
biomedich-205	212	17	and	and	CCONJ
biomedich-205	212	18	heart	heart	NOUN
biomedich-205	212	19	attack	attack	NOUN
biomedich-205	212	20	.	.	PUNCT
biomedich-205	213	1	in	in	ADP
biomedich-205	213	2	addition	addition	NOUN
biomedich-205	213	3	,	,	PUNCT
biomedich-205	213	4	high	high	ADJ
biomedich-205	213	5	levels	level	NOUN
biomedich-205	213	6	of	of	ADP
biomedich-205	213	7	apob100	apob100	PROPN
biomedich-205	213	8	and	and	CCONJ
biomedich-205	213	9	ldl	ldl	NOUN
biomedich-205	213	10	cholesterol	cholesterol	NOUN
biomedich-205	213	11	are	be	AUX
biomedich-205	213	12	directly	directly	ADV
biomedich-205	213	13	associated	associate	VERB
biomedich-205	213	14	with	with	ADP
biomedich-205	213	15	cardiovascular	cardiovascular	ADJ
biomedich-205	213	16	disease	disease	NOUN
biomedich-205	213	17	associated	associate	VERB
biomedich-205	213	18	with	with	ADP
biomedich-205	213	19	atherosclerosis	atherosclerosis	NOUN
biomedich-205	213	20	.	.	PUNCT
biomedich-205	214	1	the	the	DET
biomedich-205	214	2	lipid	lipid	NOUN
biomedich-205	214	3	cycle	cycle	NOUN
biomedich-205	214	4	usually	usually	ADV
biomedich-205	214	5	begins	begin	VERB
biomedich-205	214	6	with	with	ADP
biomedich-205	214	7	the	the	DET
biomedich-205	214	8	release	release	NOUN
biomedich-205	214	9	of	of	ADP
biomedich-205	214	10	immature	immature	ADJ
biomedich-205	214	11	vldl	vldl	NOUN
biomedich-205	214	12	by	by	ADP
biomedich-205	214	13	the	the	DET
biomedich-205	214	14	liver	liver	NOUN
biomedich-205	214	15	.	.	PUNCT
biomedich-205	215	1	it	it	PRON
biomedich-205	215	2	also	also	ADV
biomedich-205	215	3	contains	contain	VERB
biomedich-205	215	4	apob100	apob100	PROPN
biomedich-205	215	5	,	,	PUNCT
biomedich-205	215	6	cholesteryl	cholesteryl	NOUN
biomedich-205	215	7	ester	ester	NOUN
biomedich-205	215	8	,	,	PUNCT
biomedich-205	215	9	triglycerides	triglyceride	NOUN
biomedich-205	215	10	and	and	CCONJ
biomedich-205	215	11	cholesterol	cholesterol	NOUN
biomedich-205	215	12	.	.	PUNCT
biomedich-205	216	1	vldl	vldl	PROPN
biomedich-205	216	2	develops	develop	VERB
biomedich-205	216	3	in	in	ADP
biomedich-205	216	4	adipose	adipose	ADJ
biomedich-205	216	5	tissue	tissue	NOUN
biomedich-205	216	6	,	,	PUNCT
biomedich-205	216	7	skeletal	skeletal	ADJ
biomedich-205	216	8	muscle	muscle	NOUN
biomedich-205	216	9	,	,	PUNCT
biomedich-205	216	10	and	and	CCONJ
biomedich-205	216	11	myocardium	myocardium	NOUN
biomedich-205	216	12	during	during	ADP
biomedich-205	216	13	circulation	circulation	NOUN
biomedich-205	216	14	in	in	ADP
biomedich-205	216	15	the	the	DET
biomedich-205	216	16	blood	blood	NOUN
biomedich-205	216	17	and	and	CCONJ
biomedich-205	216	18	becomes	become	VERB
biomedich-205	216	19	an	an	DET
biomedich-205	216	20	energy	energy	NOUN
biomedich-205	216	21	source	source	NOUN
biomedich-205	216	22	(	(	PUNCT
biomedich-205	216	23	chaudhary	chaudhary	PROPN
biomedich-205	216	24	et	et	PROPN
biomedich-205	216	25	al	al	PROPN
biomedich-205	216	26	.	.	PROPN
biomedich-205	216	27	,	,	PUNCT
biomedich-205	216	28	2017	2017	NUM
biomedich-205	216	29	)	)	PUNCT
biomedich-205	216	30	.	.	PUNCT
biomedich-205	217	1	one	one	NUM
biomedich-205	217	2	of	of	ADP
biomedich-205	217	3	the	the	DET
biomedich-205	217	4	roles	role	NOUN
biomedich-205	217	5	of	of	ADP
biomedich-205	217	6	vldl	vldl	NOUN
biomedich-205	217	7	is	be	AUX
biomedich-205	217	8	the	the	DET
biomedich-205	217	9	exchange	exchange	NOUN
biomedich-205	217	10	and	and	CCONJ
biomedich-205	217	11	removal	removal	NOUN
biomedich-205	217	12	of	of	ADP
biomedich-205	217	13	triglycerides	triglyceride	NOUN
biomedich-205	217	14	,	,	PUNCT
biomedich-205	217	15	converting	convert	VERB
biomedich-205	217	16	vldl	vldl	NOUN
biomedich-205	217	17	to	to	ADP
biomedich-205	217	18	intermediate	intermediate	ADJ
biomedich-205	217	19	density	density	NOUN
biomedich-205	217	20	lipoprotein	lipoprotein	ADJ
biomedich-205	217	21	(	(	PUNCT
biomedich-205	217	22	idl	idl	NOUN
biomedich-205	217	23	)	)	PUNCT
biomedich-205	217	24	(	(	PUNCT
biomedich-205	217	25	shelness	shelness	NOUN
biomedich-205	217	26	&	&	CCONJ
biomedich-205	217	27	sellers	seller	NOUN
biomedich-205	217	28	,	,	PUNCT
biomedich-205	217	29	2001	2001	NUM
biomedich-205	217	30	)	)	PUNCT
biomedich-205	217	31	.	.	PUNCT
biomedich-205	218	1	some	some	PRON
biomedich-205	218	2	of	of	ADP
biomedich-205	218	3	these	these	DET
biomedich-205	218	4	idls	idl	NOUN
biomedich-205	218	5	can	can	AUX
biomedich-205	218	6	be	be	AUX
biomedich-205	218	7	eliminated	eliminate	VERB
biomedich-205	218	8	from	from	ADP
biomedich-205	218	9	the	the	DET
biomedich-205	218	10	liver	liver	NOUN
biomedich-205	218	11	during	during	ADP
biomedich-205	218	12	endocytosis	endocytosis	NOUN
biomedich-205	218	13	,	,	PUNCT
biomedich-205	218	14	but	but	CCONJ
biomedich-205	218	15	idls	idl	NOUN
biomedich-205	218	16	with	with	ADP
biomedich-205	218	17	high	high	ADJ
biomedich-205	218	18	cholesterol	cholesterol	NOUN
biomedich-205	218	19	content	content	NOUN
biomedich-205	218	20	are	be	AUX
biomedich-205	218	21	converted	convert	VERB
biomedich-205	218	22	to	to	ADP
biomedich-205	218	23	ldl	ldl	NOUN
biomedich-205	218	24	,	,	PUNCT
biomedich-205	218	25	which	which	PRON
biomedich-205	218	26	also	also	ADV
biomedich-205	218	27	contains	contain	VERB
biomedich-205	218	28	apob100	apob100	PROPN
biomedich-205	218	29	.	.	PUNCT
biomedich-205	219	1	this	this	PRON
biomedich-205	219	2	apob100	apob100	PROPN
biomedich-205	219	3	binds	bind	VERB
biomedich-205	219	4	to	to	PART
biomedich-205	219	5	ldlr	ldlr	VERB
biomedich-205	219	6	at	at	ADP
biomedich-205	219	7	its	its	PRON
biomedich-205	219	8	n	n	CCONJ
biomedich-205	219	9	-	-	PUNCT
biomedich-205	219	10	terminal	terminal	ADJ
biomedich-205	219	11	domain	domain	NOUN
biomedich-205	219	12	and	and	CCONJ
biomedich-205	219	13	passes	pass	VERB
biomedich-205	219	14	through	through	ADP
biomedich-205	219	15	acidic	acidic	ADJ
biomedich-205	219	16	endosomes	endosome	NOUN
biomedich-205	219	17	by	by	ADP
biomedich-205	219	18	endocytosis	endocytosis	NOUN
biomedich-205	219	19	.	.	PUNCT
biomedich-205	220	1	ldlr	ldlr	PROPN
biomedich-205	220	2	is	be	AUX
biomedich-205	220	3	eventually	eventually	ADV
biomedich-205	220	4	cleaved	cleave	VERB
biomedich-205	220	5	from	from	ADP
biomedich-205	220	6	ldl	ldl	NOUN
biomedich-205	220	7	and	and	CCONJ
biomedich-205	220	8	reintroduced	reintroduce	VERB
biomedich-205	220	9	into	into	ADP
biomedich-205	220	10	the	the	DET
biomedich-205	220	11	cell	cell	NOUN
biomedich-205	220	12	membrane	membrane	NOUN
biomedich-205	220	13	(	(	PUNCT
biomedich-205	220	14	ding	ding	NOUN
biomedich-205	220	15	et	et	PROPN
biomedich-205	220	16	al	al	PROPN
biomedich-205	220	17	.	.	PROPN
biomedich-205	220	18	,	,	PUNCT
biomedich-205	220	19	2015	2015	NUM
biomedich-205	220	20	)	)	PUNCT
biomedich-205	220	21	.	.	PUNCT
biomedich-205	221	1	at	at	ADP
biomedich-205	221	2	acidic	acidic	ADJ
biomedich-205	221	3	ph	ph	NOUN
biomedich-205	221	4	,	,	PUNCT
biomedich-205	221	5	changes	change	NOUN
biomedich-205	221	6	in	in	ADP
biomedich-205	221	7	ldlr	ldlr	ADJ
biomedich-205	221	8	conformation	conformation	NOUN
biomedich-205	221	9	may	may	AUX
biomedich-205	221	10	increase	increase	VERB
biomedich-205	221	11	the	the	DET
biomedich-205	221	12	affinity	affinity	NOUN
biomedich-205	221	13	of	of	ADP
biomedich-205	221	14	pcsk9	pcsk9	NOUN
biomedich-205	221	15	for	for	ADP
biomedich-205	221	16	ldlr	ldlr	PROPN
biomedich-205	221	17	compared	compare	VERB
biomedich-205	221	18	to	to	PART
biomedich-205	221	19	ldl	ldl	VERB
biomedich-205	221	20	[	[	X
biomedich-205	221	21	10	10	NUM
biomedich-205	221	22	]	]	PUNCT
biomedich-205	221	23	.	.	PUNCT
biomedich-205	222	1	mutations	mutation	NOUN
biomedich-205	222	2	can	can	AUX
biomedich-205	222	3	eliminate	eliminate	VERB
biomedich-205	222	4	the	the	DET
biomedich-205	222	5	catalytic	catalytic	ADJ
biomedich-205	222	6	activity	activity	NOUN
biomedich-205	222	7	of	of	ADP
biomedich-205	222	8	pcsk9	pcsk9	PROPN
biomedich-205	222	9	,	,	PUNCT
biomedich-205	222	10	but	but	CCONJ
biomedich-205	222	11	do	do	AUX
biomedich-205	222	12	not	not	PART
biomedich-205	222	13	impair	impair	VERB
biomedich-205	222	14	its	its	PRON
biomedich-205	222	15	ability	ability	NOUN
biomedich-205	222	16	to	to	PART
biomedich-205	222	17	bind	bind	VERB
biomedich-205	222	18	to	to	ADP
biomedich-205	222	19	ldlr	ldlr	PROPN
biomedich-205	222	20	.	.	PUNCT
biomedich-205	223	1	interfering	interfere	VERB
biomedich-205	223	2	with	with	ADP
biomedich-205	223	3	protein	protein	NOUN
biomedich-205	223	4	production	production	NOUN
biomedich-205	223	5	,	,	PUNCT
biomedich-205	223	6	can	can	AUX
biomedich-205	223	7	block	block	VERB
biomedich-205	223	8	binding	bind	VERB
biomedich-205	223	9	to	to	ADP
biomedich-205	223	10	the	the	DET
biomedich-205	223	11	ldlr	ldlr	NOUN
biomedich-205	223	12	.	.	PUNCT
biomedich-205	224	1	degradation	degradation	NOUN
biomedich-205	224	2	of	of	ADP
biomedich-205	224	3	pcsk9	pcsk9	PROPN
biomedich-205	224	4	mrna	mrna	PROPN
biomedich-205	224	5	can	can	AUX
biomedich-205	224	6	ultimately	ultimately	ADV
biomedich-205	224	7	prevent	prevent	VERB
biomedich-205	224	8	its	its	PRON
biomedich-205	224	9	association	association	NOUN
biomedich-205	224	10	with	with	ADP
biomedich-205	224	11	ldlr	ldlr	PROPN
biomedich-205	224	12	.	.	PUNCT
biomedich-205	225	1	alternatively	alternatively	ADV
biomedich-205	225	2	,	,	PUNCT
biomedich-205	225	3	the	the	DET
biomedich-205	225	4	same	same	ADJ
biomedich-205	225	5	can	can	AUX
biomedich-205	225	6	be	be	AUX
biomedich-205	225	7	done	do	VERB
biomedich-205	225	8	with	with	ADP
biomedich-205	225	9	small	small	ADJ
biomedich-205	225	10	medicines	medicine	NOUN
biomedich-205	225	11	designed	design	VERB
biomedich-205	225	12	to	to	PART
biomedich-205	225	13	prevent	prevent	VERB
biomedich-205	225	14	this	this	DET
biomedich-205	225	15	relationship	relationship	NOUN
biomedich-205	225	16	(	(	PUNCT
biomedich-205	225	17	mcnutt	mcnutt	PROPN
biomedich-205	225	18	et	et	PROPN
biomedich-205	225	19	al	al	PROPN
biomedich-205	225	20	.	.	PROPN
biomedich-205	225	21	,	,	PUNCT
biomedich-205	225	22	2007	2007	NUM
biomedich-205	225	23	)	)	PUNCT
biomedich-205	225	24	.	.	PUNCT
biomedich-205	226	1	atherosclerosis	atherosclerosis	NOUN
biomedich-205	226	2	is	be	AUX
biomedich-205	226	3	caused	cause	VERB
biomedich-205	226	4	by	by	ADP
biomedich-205	226	5	the	the	DET
biomedich-205	226	6	interaction	interaction	NOUN
biomedich-205	226	7	of	of	ADP
biomedich-205	226	8	pcsk9	pcsk9	NOUN
biomedich-205	226	9	with	with	ADP
biomedich-205	226	10	ldlr	ldlr	PROPN
biomedich-205	226	11	(	(	PUNCT
biomedich-205	226	12	egfa	egfa	NOUN
biomedich-205	226	13	domain	domain	NOUN
biomedich-205	226	14	or	or	CCONJ
biomedich-205	226	15	epidermal	epidermal	ADJ
biomedich-205	226	16	growth	growth	NOUN
biomedich-205	226	17	factor	factor	NOUN
biomedich-205	226	18	-	-	PUNCT
biomedich-205	226	19	like	like	ADJ
biomedich-205	226	20	repeat	repeat	NOUN
biomedich-205	226	21	)	)	PUNCT
biomedich-205	226	22	and	and	CCONJ
biomedich-205	226	23	inhibits	inhibit	VERB
biomedich-205	226	24	ldl	ldl	NOUN
biomedich-205	226	25	endocytosis	endocytosis	NOUN
biomedich-205	226	26	.	.	PUNCT
biomedich-205	227	1	you	you	PRON
biomedich-205	227	2	can	can	AUX
biomedich-205	227	3	block	block	VERB
biomedich-205	227	4	the	the	DET
biomedich-205	227	5	connection	connection	NOUN
biomedich-205	227	6	between	between	ADP
biomedich-205	227	7	pcsk9	pcsk9	PROPN
biomedich-205	227	8	and	and	CCONJ
biomedich-205	227	9	ldlr	ldlr	ADJ
biomedich-205	227	10	to	to	PART
biomedich-205	227	11	stop	stop	VERB
biomedich-205	227	12	ldl	ldl	NOUN
biomedich-205	227	13	accumulation	accumulation	NOUN
biomedich-205	227	14	.	.	PUNCT
biomedich-205	228	1	pcsk9	pcsk9	PROPN
biomedich-205	228	2	is	be	AUX
biomedich-205	228	3	produced	produce	VERB
biomedich-205	228	4	in	in	ADP
biomedich-205	228	5	the	the	DET
biomedich-205	228	6	er	er	INTJ
biomedich-205	228	7	and	and	CCONJ
biomedich-205	228	8	transcribed	transcribe	VERB
biomedich-205	228	9	into	into	ADP
biomedich-205	228	10	the	the	DET
biomedich-205	228	11	plasma	plasma	NOUN
biomedich-205	228	12	membrane	membrane	NOUN
biomedich-205	228	13	to	to	PART
biomedich-205	228	14	interact	interact	VERB
biomedich-205	228	15	with	with	ADP
biomedich-205	228	16	the	the	DET
biomedich-205	228	17	ldlr	ldlr	NOUN
biomedich-205	228	18	.	.	PUNCT
biomedich-205	229	1	proteinprotein	proteinprotein	ADJ
biomedich-205	229	2	interactions	interaction	NOUN
biomedich-205	229	3	control	control	VERB
biomedich-205	229	4	a	a	DET
biomedich-205	229	5	significant	significant	ADJ
biomedich-205	229	6	number	number	NOUN
biomedich-205	229	7	of	of	ADP
biomedich-205	229	8	biological	biological	ADJ
biomedich-205	229	9	activities	activity	NOUN
biomedich-205	229	10	.	.	PUNCT
biomedich-205	230	1	ace	ace	VERB
biomedich-205	230	2	inhibitors	inhibitor	NOUN
biomedich-205	230	3	(	(	PUNCT
biomedich-205	230	4	table	table	NOUN
biomedich-205	230	5	1	1	NUM
biomedich-205	230	6	)	)	PUNCT
biomedich-205	230	7	have	have	AUX
biomedich-205	230	8	been	be	AUX
biomedich-205	230	9	shown	show	VERB
biomedich-205	230	10	to	to	PART
biomedich-205	230	11	play	play	VERB
biomedich-205	230	12	an	an	DET
biomedich-205	230	13	active	active	ADJ
biomedich-205	230	14	role	role	NOUN
biomedich-205	230	15	in	in	ADP
biomedich-205	230	16	the	the	DET
biomedich-205	230	17	prevention	prevention	NOUN
biomedich-205	230	18	of	of	ADP
biomedich-205	230	19	atherosclerosis	atherosclerosis	NOUN
biomedich-205	230	20	.	.	PUNCT
biomedich-205	231	1	therefore	therefore	ADV
biomedich-205	231	2	,	,	PUNCT
biomedich-205	231	3	pharmacophore	pharmacophore	NOUN
biomedich-205	231	4	modeling	modeling	NOUN
biomedich-205	231	5	and	and	CCONJ
biomedich-205	231	6	screening	screen	VERB
biomedich-205	231	7	using	use	VERB
biomedich-205	231	8	the	the	DET
biomedich-205	231	9	zinc	zinc	NOUN
biomedich-205	231	10	database	database	NOUN
biomedich-205	231	11	has	have	AUX
biomedich-205	231	12	been	be	AUX
biomedich-205	231	13	introduced	introduce	VERB
biomedich-205	231	14	into	into	ADP
biomedich-205	231	15	the	the	DET
biomedich-205	231	16	drug	drug	NOUN
biomedich-205	231	17	development	development	NOUN
biomedich-205	231	18	process	process	NOUN
biomedich-205	231	19	.	.	PUNCT
biomedich-205	232	1	the	the	DET
biomedich-205	232	2	binding	bind	VERB
biomedich-205	232	3	affinity	affinity	NOUN
biomedich-205	232	4	of	of	ADP
biomedich-205	232	5	the	the	DET
biomedich-205	232	6	newly	newly	ADV
biomedich-205	232	7	identified	identify	VERB
biomedich-205	232	8	chemical	chemical	NOUN
biomedich-205	232	9	(	(	PUNCT
biomedich-205	232	10	1033	1033	NUM
biomedich-205	232	11	)	)	PUNCT
biomedich-205	232	12	from	from	ADP
biomedich-205	232	13	the	the	DET
biomedich-205	232	14	zinc	zinc	NOUN
biomedich-205	232	15	database	database	NOUN
biomedich-205	232	16	was	be	AUX
biomedich-205	232	17	assessed	assess	VERB
biomedich-205	232	18	using	use	VERB
biomedich-205	232	19	the	the	DET
biomedich-205	232	20	autodock	autodock	NOUN
biomedich-205	232	21	tool	tool	NOUN
biomedich-205	232	22	.	.	PUNCT
biomedich-205	233	1	the	the	DET
biomedich-205	233	2	program	program	NOUN
biomedich-205	233	3	calculated	calculate	VERB
biomedich-205	233	4	several	several	ADJ
biomedich-205	233	5	factors	factor	NOUN
biomedich-205	233	6	,	,	PUNCT
biomedich-205	233	7	including	include	VERB
biomedich-205	233	8	reduced	reduce	VERB
biomedich-205	233	9	binding	bind	VERB
biomedich-205	233	10	energy	energy	NOUN
biomedich-205	233	11	,	,	PUNCT
biomedich-205	233	12	interaction	interaction	NOUN
biomedich-205	233	13	with	with	ADP
biomedich-205	233	14	the	the	DET
biomedich-205	233	15	active	active	ADJ
biomedich-205	233	16	site	site	NOUN
biomedich-205	233	17	,	,	PUNCT
biomedich-205	233	18	and	and	CCONJ
biomedich-205	233	19	the	the	DET
biomedich-205	233	20	number	number	NOUN
biomedich-205	233	21	of	of	ADP
biomedich-205	233	22	hydrogen	hydrogen	NOUN
biomedich-205	233	23	bonds	bond	NOUN
biomedich-205	233	24	.	.	PUNCT
biomedich-205	234	1	comparing	compare	VERB
biomedich-205	234	2	these	these	DET
biomedich-205	234	3	criteria	criterion	NOUN
biomedich-205	234	4	yielded	yield	VERB
biomedich-205	234	5	a	a	DET
biomedich-205	234	6	list	list	NOUN
biomedich-205	234	7	of	of	ADP
biomedich-205	234	8	the	the	DET
biomedich-205	234	9	10	10	NUM
biomedich-205	234	10	most	most	ADV
biomedich-205	234	11	promising	promising	ADJ
biomedich-205	234	12	drug	drug	NOUN
biomedich-205	234	13	candidates	candidate	NOUN
biomedich-205	234	14	for	for	ADP
biomedich-205	234	15	atherosclerosis	atherosclerosis	NOUN
biomedich-205	234	16	(	(	PUNCT
biomedich-205	234	17	table	table	NOUN
biomedich-205	234	18	2	2	NUM
biomedich-205	234	19	)	)	PUNCT
biomedich-205	234	20	.	.	PUNCT
biomedich-205	235	1	some	some	PRON
biomedich-205	235	2	of	of	ADP
biomedich-205	235	3	the	the	DET
biomedich-205	235	4	molecules	molecule	NOUN
biomedich-205	235	5	virtually	virtually	ADV
biomedich-205	235	6	screened	screen	VERB
biomedich-205	235	7	from	from	ADP
biomedich-205	235	8	the	the	DET
biomedich-205	235	9	zinc	zinc	NOUN
biomedich-205	235	10	database	database	NOUN
biomedich-205	235	11	showed	show	VERB
biomedich-205	235	12	good	good	ADJ
biomedich-205	235	13	interactions	interaction	NOUN
biomedich-205	235	14	,	,	PUNCT
biomedich-205	235	15	while	while	SCONJ
biomedich-205	235	16	others	other	NOUN
biomedich-205	235	17	showed	show	VERB
biomedich-205	235	18	no	no	PRON
biomedich-205	235	19	or	or	CCONJ
biomedich-205	235	20	weak	weak	ADJ
biomedich-205	235	21	interactions	interaction	NOUN
biomedich-205	235	22	.	.	PUNCT
biomedich-205	236	1	the	the	DET
biomedich-205	236	2	results	result	NOUN
biomedich-205	236	3	show	show	VERB
biomedich-205	236	4	that	that	SCONJ
biomedich-205	236	5	the	the	DET
biomedich-205	236	6	top	top	ADJ
biomedich-205	236	7	10	10	NUM
biomedich-205	236	8	compounds	compound	NOUN
biomedich-205	236	9	with	with	ADP
biomedich-205	236	10	a	a	DET
biomedich-205	236	11	binding	bind	VERB
biomedich-205	236	12	energy	energy	NOUN
biomedich-205	236	13	of	of	ADP
biomedich-205	236	14	9.8	9.8	NUM
biomedich-205	236	15	-	-	SYM
biomedich-205	236	16	8.2	8.2	NUM
biomedich-205	236	17	kcal	kcal	NOUN
biomedich-205	236	18	/	/	SYM
biomedich-205	236	19	mol	mol	PROPN
biomedich-205	236	20	(	(	PUNCT
biomedich-205	236	21	table	table	NOUN
biomedich-205	236	22	2	2	NUM
biomedich-205	236	23	)	)	PUNCT
biomedich-205	236	24	are	be	AUX
biomedich-205	236	25	similar	similar	ADJ
biomedich-205	236	26	to	to	ADP
biomedich-205	236	27	the	the	DET
biomedich-205	236	28	reference	reference	NOUN
biomedich-205	236	29	compounds	compound	NOUN
biomedich-205	236	30	(	(	PUNCT
biomedich-205	236	31	table	table	NOUN
biomedich-205	236	32	1	1	NUM
biomedich-205	236	33	)	)	PUNCT
biomedich-205	236	34	and	and	CCONJ
biomedich-205	236	35	are	be	AUX
biomedich-205	236	36	therefore	therefore	ADV
biomedich-205	236	37	desirable	desirable	ADJ
biomedich-205	236	38	and	and	CCONJ
biomedich-205	236	39	viable	viable	ADJ
biomedich-205	236	40	drug	drug	NOUN
biomedich-205	236	41	candidates	candidate	NOUN
biomedich-205	236	42	.	.	PUNCT
biomedich-205	237	1	candidate	candidate	NOUN
biomedich-205	237	2	target	target	NOUN
biomedich-205	237	3	for	for	ADP
biomedich-205	237	4	pcsk9	pcsk9	NOUN
biomedich-205	237	5	in	in	ADP
biomedich-205	237	6	atherosclerosis	atherosclerosis	NOUN
biomedich-205	237	7	.	.	PUNCT
biomedich-205	238	1	in	in	ADP
biomedich-205	238	2	other	other	ADJ
biomedich-205	238	3	words	word	NOUN
biomedich-205	238	4	,	,	PUNCT
biomedich-205	238	5	in	in	ADP
biomedich-205	238	6	this	this	DET
biomedich-205	238	7	study	study	NOUN
biomedich-205	238	8	,	,	PUNCT
biomedich-205	238	9	the	the	DET
biomedich-205	238	10	topselected	topselecte	VERB
biomedich-205	238	11	compounds	compound	NOUN
biomedich-205	238	12	showed	show	VERB
biomedich-205	238	13	the	the	DET
biomedich-205	238	14	highest	high	ADJ
biomedich-205	238	15	binding	bind	VERB
biomedich-205	238	16	affinity	affinity	NOUN
biomedich-205	238	17	for	for	ADP
biomedich-205	238	18	the	the	DET
biomedich-205	238	19	pcsk9	pcsk9	NOUN
biomedich-205	238	20	target	target	NOUN
biomedich-205	238	21	protein	protein	NOUN
biomedich-205	238	22	for	for	ADP
biomedich-205	238	23	atherosclerosis	atherosclerosis	NOUN
biomedich-205	238	24	.	.	PUNCT
biomedich-205	239	1	in	in	ADP
biomedich-205	239	2	addition	addition	NOUN
biomedich-205	239	3	,	,	PUNCT
biomedich-205	239	4	molinspiration	molinspiration	NOUN
biomedich-205	239	5	,	,	PUNCT
biomedich-205	239	6	computational	computational	ADJ
biomedich-205	239	7	structural	structural	ADJ
biomedich-205	239	8	analysis	analysis	NOUN
biomedich-205	239	9	of	of	ADP
biomedich-205	239	10	these	these	DET
biomedich-205	239	11	compounds	compound	NOUN
biomedich-205	239	12	using	use	VERB
biomedich-205	239	13	swiss	swiss	ADJ
biomedich-205	239	14	adme	adme	NOUN
biomedich-205	239	15	,	,	PUNCT
biomedich-205	239	16	drug	drug	NOUN
biomedich-205	239	17	similarity	similarity	NOUN
biomedich-205	239	18	,	,	PUNCT
biomedich-205	239	19	adme	adme	NOUN
biomedich-205	239	20	properties	property	NOUN
biomedich-205	239	21	,	,	PUNCT
biomedich-205	239	22	and	and	CCONJ
biomedich-205	239	23	oral	oral	ADJ
biomedich-205	239	24	bioavailability	bioavailability	NOUN
biomedich-205	239	25	,	,	PUNCT
biomedich-205	239	26	based	base	VERB
biomedich-205	239	27	on	on	ADP
biomedich-205	239	28	these	these	DET
biomedich-205	239	29	results	result	NOUN
biomedich-205	239	30	,	,	PUNCT
biomedich-205	239	31	(	(	PUNCT
biomedich-205	239	32	s	s	X
biomedich-205	239	33	)	)	PUNCT
biomedich-205	239	34	canadin	canadin	NOUN
biomedich-205	239	35	,	,	PUNCT
biomedich-205	239	36	hesperetin	hesperetin	NOUN
biomedich-205	239	37	,	,	PUNCT
biomedich-205	239	38	and	and	CCONJ
biomedich-205	239	39	labetalol	labetalol	NOUN
biomedich-205	239	40	contain	contain	VERB
biomedich-205	239	41	heavy	heavy	ADJ
biomedich-205	239	42	atoms	atom	NOUN
biomedich-205	239	43	and	and	CCONJ
biomedich-205	239	44	have	have	VERB
biomedich-205	239	45	le	le	X
biomedich-205	239	46	and	and	CCONJ
biomedich-205	239	47	lelp	lelp	VERB
biomedich-205	239	48	values	value	NOUN
biomedich-205	239	49	,	,	PUNCT
biomedich-205	239	50	which	which	PRON
biomedich-205	239	51	is	be	AUX
biomedich-205	239	52	why	why	SCONJ
biomedich-205	239	53	further	further	ADJ
biomedich-205	239	54	research	research	NOUN
biomedich-205	239	55	and	and	CCONJ
biomedich-205	239	56	possible	possible	ADJ
biomedich-205	239	57	design	design	NOUN
biomedich-205	239	58	of	of	ADP
biomedich-205	239	59	new	new	ADJ
biomedich-205	239	60	drugs	drug	NOUN
biomedich-205	239	61	based	base	VERB
biomedich-205	239	62	on	on	ADP
biomedich-205	239	63	pharmacophore	pharmacophore	ADJ
biomedich-205	239	64	structure	structure	NOUN
biomedich-205	239	65	is	be	AUX
biomedich-205	239	66	the	the	DET
biomedich-205	239	67	most	most	ADJ
biomedich-205	239	68	.	.	PUNCT
biomedich-205	240	1	we	we	PRON
biomedich-205	240	2	can	can	AUX
biomedich-205	240	3	conclude	conclude	VERB
biomedich-205	240	4	that	that	SCONJ
biomedich-205	240	5	it	it	PRON
biomedich-205	240	6	is	be	AUX
biomedich-205	240	7	a	a	DET
biomedich-205	240	8	promising	promising	ADJ
biomedich-205	240	9	candidate	candidate	NOUN
biomedich-205	240	10	.	.	PUNCT
biomedich-205	241	1	same	same	ADJ
biomedich-205	241	2	range	range	NOUN
biomedich-205	241	3	as	as	ADP
biomedich-205	241	4	known	know	VERB
biomedich-205	241	5	ace	ace	NOUN
biomedich-205	241	6	inhibitors	inhibitor	NOUN
biomedich-205	241	7	(	(	PUNCT
biomedich-205	241	8	tables	table	NOUN
biomedich-205	241	9	1	1	NUM
biomedich-205	241	10	and	and	CCONJ
biomedich-205	241	11	4	4	NUM
biomedich-205	241	12	)	)	PUNCT
biomedich-205	241	13	.	.	PUNCT
biomedich-205	242	1	the	the	DET
biomedich-205	242	2	results	result	NOUN
biomedich-205	242	3	of	of	ADP
biomedich-205	242	4	autodockvina	autodockvina	NOUN
biomedich-205	242	5	led	lead	VERB
biomedich-205	242	6	to	to	ADP
biomedich-205	242	7	the	the	DET
biomedich-205	242	8	selection	selection	NOUN
biomedich-205	242	9	for	for	ADP
biomedich-205	242	10	further	further	ADJ
biomedich-205	242	11	molecular	molecular	ADJ
biomedich-205	242	12	dynamics	dynamic	NOUN
biomedich-205	242	13	analysis	analysis	NOUN
biomedich-205	242	14	of	of	ADP
biomedich-205	242	15	the	the	DET
biomedich-205	242	16	complex	complex	NOUN
biomedich-205	242	17	with	with	ADP
biomedich-205	242	18	pcsk9	pcsk9	PROPN
biomedich-205	242	19	.	.	PUNCT
biomedich-205	243	1	during	during	ADP
biomedich-205	243	2	molecular	molecular	ADJ
biomedich-205	243	3	dynamics	dynamic	NOUN
biomedich-205	243	4	,	,	PUNCT
biomedich-205	243	5	all	all	DET
biomedich-205	243	6	three	three	NUM
biomedich-205	243	7	compounds	compound	NOUN
biomedich-205	243	8	appeared	appear	VERB
biomedich-205	243	9	to	to	PART
biomedich-205	243	10	form	form	VERB
biomedich-205	243	11	a	a	DET
biomedich-205	243	12	stable	stable	ADJ
biomedich-205	243	13	pcsk9ligand	pcsk9ligand	NOUN
biomedich-205	243	14	complex	complex	NOUN
biomedich-205	243	15	,	,	PUNCT
biomedich-205	243	16	staying	stay	VERB
biomedich-205	243	17	at	at	ADP
biomedich-205	243	18	the	the	DET
biomedich-205	243	19	docking	docking	NOUN
biomedich-205	243	20	site	site	NOUN
biomedich-205	243	21	for	for	ADP
biomedich-205	243	22	at	at	ADV
biomedich-205	243	23	least	least	ADV
biomedich-205	243	24	10	10	NUM
biomedich-205	243	25	ns	ns	ADJ
biomedich-205	243	26	,	,	PUNCT
biomedich-205	243	27	and	and	CCONJ
biomedich-205	243	28	their	their	PRON
biomedich-205	243	29	heavy	heavy	ADJ
biomedich-205	243	30	atom	atom	NOUN
biomedich-205	243	31	rmsd	rmsd	NOUN
biomedich-205	243	32	values	value	NOUN
biomedich-205	243	33	were	be	AUX
biomedich-205	243	34	minimal	minimal	ADJ
biomedich-205	243	35	.	.	PUNCT
biomedich-205	244	1	a	a	DET
biomedich-205	244	2	notable	notable	ADJ
biomedich-205	244	3	advantage	advantage	NOUN
biomedich-205	244	4	of	of	ADP
biomedich-205	244	5	(	(	PUNCT
biomedich-205	244	6	s	s	NOUN
biomedich-205	244	7	)	)	PUNCT
biomedich-205	244	8	canadine	canadine	NOUN
biomedich-205	244	9	,	,	PUNCT
biomedich-205	244	10	also	also	ADV
biomedich-205	244	11	known	know	VERB
biomedich-205	244	12	as	as	ADP
biomedich-205	244	13	(	(	PUNCT
biomedich-205	244	14	s	s	NOUN
biomedich-205	244	15	)	)	PUNCT
biomedich-205	244	16	tetrahydroberberine	tetrahydroberberine	NOUN
biomedich-205	244	17	,	,	PUNCT
biomedich-205	244	18	is	be	AUX
biomedich-205	244	19	a	a	DET
biomedich-205	244	20	significant	significant	ADJ
biomedich-205	244	21	reduction	reduction	NOUN
biomedich-205	244	22	in	in	ADP
biomedich-205	244	23	rmsd	rmsd	NOUN
biomedich-205	244	24	(	(	PUNCT
biomedich-205	244	25	figure	figure	NOUN
biomedich-205	244	26	5	5	NUM
biomedich-205	244	27	)	)	PUNCT
biomedich-205	244	28	,	,	PUNCT
biomedich-205	244	29	which	which	PRON
biomedich-205	244	30	promotes	promote	VERB
biomedich-205	244	31	the	the	DET
biomedich-205	244	32	formation	formation	NOUN
biomedich-205	244	33	of	of	ADP
biomedich-205	244	34	a	a	DET
biomedich-205	244	35	highly	highly	ADV
biomedich-205	244	36	stable	stable	ADJ
biomedich-205	244	37	complex	complex	NOUN
biomedich-205	244	38	with	with	ADP
biomedich-205	244	39	pcsk9	pcsk9	PROPN
biomedich-205	244	40	.	.	PUNCT
biomedich-205	245	1	this	this	PRON
biomedich-205	245	2	is	be	AUX
biomedich-205	245	3	an	an	DET
biomedich-205	245	4	interesting	interesting	ADJ
biomedich-205	245	5	finding	finding	NOUN
biomedich-205	245	6	,	,	PUNCT
biomedich-205	245	7	as	as	SCONJ
biomedich-205	245	8	studies	study	NOUN
biomedich-205	245	9	suggest	suggest	VERB
biomedich-205	245	10	that	that	SCONJ
biomedich-205	245	11	berberine	berberine	NOUN
biomedich-205	245	12	inhibits	inhibit	VERB
biomedich-205	245	13	psck9	psck9	NOUN
biomedich-205	245	14	(	(	PUNCT
biomedich-205	245	15	xu	xu	INTJ
biomedich-205	245	16	et	et	PROPN
biomedich-205	245	17	al	al	PROPN
biomedich-205	245	18	.	.	PROPN
biomedich-205	245	19	,	,	PUNCT
biomedich-205	245	20	2019	2019	NUM
biomedich-205	245	21	)	)	PUNCT
biomedich-205	245	22	.	.	PUNCT
biomedich-205	246	1	although	although	SCONJ
biomedich-205	246	2	the	the	DET
biomedich-205	246	3	direct	direct	ADJ
biomedich-205	246	4	inhibitory	inhibitory	ADJ
biomedich-205	246	5	effect	effect	NOUN
biomedich-205	246	6	of	of	ADP
biomedich-205	246	7	such	such	ADJ
biomedich-205	246	8	compounds	compound	NOUN
biomedich-205	246	9	is	be	AUX
biomedich-205	246	10	unknown	unknown	ADJ
biomedich-205	246	11	,	,	PUNCT
biomedich-205	246	12	this	this	DET
biomedich-205	246	13	study	study	NOUN
biomedich-205	246	14	provides	provide	VERB
biomedich-205	246	15	insights	insight	NOUN
biomedich-205	246	16	into	into	ADP
biomedich-205	246	17	(	(	PUNCT
biomedich-205	246	18	s	s	X
biomedich-205	246	19	)	)	PUNCT
biomedich-205	246	20	canadin	canadin	NOUN
biomedich-205	246	21	and	and	CCONJ
biomedich-205	246	22	berberine	berberine	NOUN
biomedich-205	246	23	with	with	ADP
biomedich-205	246	24	very	very	ADV
biomedich-205	246	25	similar	similar	ADJ
biomedich-205	246	26	pharmacophore	pharmacophore	NOUN
biomedich-205	246	27	structures	structure	NOUN
biomedich-205	246	28	that	that	PRON
biomedich-205	246	29	differ	differ	VERB
biomedich-205	246	30	only	only	ADV
biomedich-205	246	31	in	in	ADP
biomedich-205	246	32	the	the	DET
biomedich-205	246	33	degree	degree	NOUN
biomedich-205	246	34	of	of	ADP
biomedich-205	246	35	hydrogen	hydrogen	NOUN
biomedich-205	246	36	atom	atom	NOUN
biomedich-205	246	37	saturation	saturation	NOUN
biomedich-205	246	38	.	.	PUNCT
biomedich-205	247	1	increase	increase	NOUN
biomedich-205	247	2	.	.	PUNCT
biomedich-205	248	1	berberine	berberine	NOUN
biomedich-205	248	2	is	be	AUX
biomedich-205	248	3	an	an	DET
biomedich-205	248	4	aromatic	aromatic	ADJ
biomedich-205	248	5	chemical	chemical	NOUN
biomedich-205	248	6	,	,	PUNCT
biomedich-205	248	7	but	but	CCONJ
biomedich-205	248	8	(	(	PUNCT
biomedich-205	248	9	s	s	X
biomedich-205	248	10	)	)	PUNCT
biomedich-205	248	11	canadine	canadine	NOUN
biomedich-205	248	12	is	be	AUX
biomedich-205	248	13	not	not	PART
biomedich-205	248	14	.	.	PUNCT
biomedich-205	249	1	experimental	experimental	ADJ
biomedich-205	249	2	studies	study	NOUN
biomedich-205	249	3	in	in	ADP
biomedich-205	249	4	mice	mouse	NOUN
biomedich-205	249	5	have	have	AUX
biomedich-205	249	6	found	find	VERB
biomedich-205	249	7	that	that	SCONJ
biomedich-205	249	8	berberine	berberine	NOUN
biomedich-205	249	9	delays	delay	VERB
biomedich-205	249	10	the	the	DET
biomedich-205	249	11	onset	onset	NOUN
biomedich-205	249	12	of	of	ADP
biomedich-205	249	13	atherosclerosis	atherosclerosis	NOUN
biomedich-205	249	14	in	in	ADP
biomedich-205	249	15	cholesterol	cholesterol	NOUN
biomedich-205	249	16	-	-	PUNCT
biomedich-205	249	17	fed	feed	VERB
biomedich-205	249	18	apoe	apoe	NOUN
biomedich-205	249	19	/	/	SYM
biomedich-205	249	20	knockout	knockout	NOUN
biomedich-205	249	21	mice	mouse	NOUN
biomedich-205	249	22	(	(	PUNCT
biomedich-205	249	23	wan	wan	PROPN
biomedich-205	249	24	et	et	PROPN
biomedich-205	249	25	al	al	PROPN
biomedich-205	249	26	.	.	PROPN
biomedich-205	249	27	,	,	PUNCT
biomedich-205	249	28	2018	2018	NUM
biomedich-205	249	29	)	)	PUNCT
biomedich-205	249	30	.	.	PUNCT
biomedich-205	250	1	in	in	ADP
biomedich-205	250	2	addition	addition	NOUN
biomedich-205	250	3	,	,	PUNCT
biomedich-205	250	4	a	a	DET
biomedich-205	250	5	study	study	NOUN
biomedich-205	250	6	of	of	ADP
biomedich-205	250	7	the	the	DET
biomedich-205	250	8	coptis	coptis	ADJ
biomedich-205	250	9	chinensis	chinensis	NOUN
biomedich-205	250	10	decoction	decoction	NOUN
biomedich-205	250	11	network	network	NOUN
biomedich-205	250	12	path	path	NOUN
biomedich-205	250	13	,	,	PUNCT
biomedich-205	250	14	a	a	DET
biomedich-205	250	15	traditional	traditional	ADJ
biomedich-205	250	16	chinese	chinese	ADJ
biomedich-205	250	17	healing	healing	NOUN
biomedich-205	250	18	method	method	NOUN
biomedich-205	250	19	,	,	PUNCT
biomedich-205	250	20	revealed	reveal	VERB
biomedich-205	250	21	:	:	PUNCT
biomedich-205	250	22	based	base	VERB
biomedich-205	250	23	on	on	ADP
biomedich-205	250	24	these	these	DET
biomedich-205	250	25	results	result	NOUN
biomedich-205	250	26	,	,	PUNCT
biomedich-205	250	27	(	(	PUNCT
biomedich-205	250	28	s	s	X
biomedich-205	250	29	)	)	PUNCT
biomedich-205	250	30	canadin	canadin	NOUN
biomedich-205	250	31	,	,	PUNCT
biomedich-205	250	32	hesperetin	hesperetin	NOUN
biomedich-205	250	33	,	,	PUNCT
biomedich-205	250	34	and	and	CCONJ
biomedich-205	250	35	labetalol	labetalol	NOUN
biomedich-205	250	36	are	be	AUX
biomedich-205	250	37	the	the	DET
biomedich-205	250	38	most	most	ADV
biomedich-205	250	39	promising	promising	ADJ
biomedich-205	250	40	candidates	candidate	NOUN
biomedich-205	250	41	for	for	ADP
biomedich-205	250	42	further	further	ADJ
biomedich-205	250	43	research	research	NOUN
biomedich-205	250	44	,	,	PUNCT
biomedich-205	250	45	and	and	CCONJ
biomedich-205	250	46	(	(	PUNCT
biomedich-205	250	47	seidah	seidah	NOUN
biomedich-205	250	48	et	et	PROPN
biomedich-205	250	49	al	al	PROPN
biomedich-205	250	50	.	.	PROPN
biomedich-205	250	51	,	,	PUNCT
biomedich-205	250	52	2017	2017	NUM
biomedich-205	250	53	)	)	PUNCT
biomedich-205	250	54	the	the	DET
biomedich-205	250	55	potential	potential	NOUN
biomedich-205	250	56	for	for	ADP
biomedich-205	250	57	new	new	ADJ
biomedich-205	250	58	drug	drug	NOUN
biomedich-205	250	59	development	development	NOUN
biomedich-205	250	60	based	base	VERB
biomedich-205	250	61	on	on	ADP
biomedich-205	250	62	the	the	DET
biomedich-205	250	63	study	study	NOUN
biomedich-205	250	64	is	be	AUX
biomedich-205	250	65	(	(	PUNCT
biomedich-205	250	66	s	s	X
biomedich-205	250	67	)	)	PUNCT
biomedich-205	250	68	canadin	canadin	NOUN
biomedich-205	250	69	and	and	CCONJ
biomedich-205	250	70	berberine	berberine	NOUN
biomedich-205	250	71	.	.	PUNCT
biomedich-205	251	1	we	we	PRON
biomedich-205	251	2	can	can	AUX
biomedich-205	251	3	conclude	conclude	VERB
biomedich-205	251	4	that	that	SCONJ
biomedich-205	251	5	it	it	PRON
biomedich-205	251	6	indicates	indicate	VERB
biomedich-205	251	7	that	that	PRON
biomedich-205	251	8	.	.	PUNCT
biomedich-205	252	1	of	of	ADP
biomedich-205	252	2	the	the	DET
biomedich-205	252	3	most	most	ADV
biomedich-205	252	4	probable	probable	ADJ
biomedich-205	252	5	drug	drug	NOUN
biomedich-205	252	6	for	for	ADP
biomedich-205	252	7	atherosclerosis	atherosclerosis	NOUN
biomedich-205	252	8	.	.	PUNCT
biomedich-205	253	1	in	in	ADP
biomedich-205	253	2	vivo	vivo	ADJ
biomedich-205	253	3	studies	study	NOUN
biomedich-205	253	4	conducted	conduct	VERB
biomedich-205	253	5	with	with	ADP
biomedich-205	253	6	hesperetin	hesperetin	NOUN
biomedich-205	253	7	to	to	PART
biomedich-205	253	8	assess	assess	VERB
biomedich-205	253	9	its	its	PRON
biomedich-205	253	10	role	role	NOUN
biomedich-205	253	11	in	in	ADP
biomedich-205	253	12	ldlr	ldlr	ADJ
biomedich-205	253	13	expression	expression	NOUN
biomedich-205	253	14	showed	show	VERB
biomedich-205	253	15	that	that	SCONJ
biomedich-205	253	16	hesperetin	hesperetin	NOUN
biomedich-205	253	17	dose	dose	NOUN
biomedich-205	253	18	(	(	PUNCT
biomedich-205	253	19	200	200	NUM
biomedich-205	253	20	m	m	NOUN
biomedich-205	253	21	)	)	PUNCT
biomedich-205	253	22	stimulated	stimulate	VERB
biomedich-205	253	23	ldlr	ldlr	ADJ
biomedich-205	253	24	gene	gene	NOUN
biomedich-205	253	25	expression	expression	NOUN
biomedich-205	253	26	,	,	PUNCT
biomedich-205	253	27	increased	increase	VERB
biomedich-205	253	28	mrna	mrna	PROPN
biomedich-205	253	29	levels	level	NOUN
biomedich-205	253	30	of	of	ADP
biomedich-205	253	31	transcription	transcription	NOUN
biomedich-205	253	32	factors	factor	VERB
biomedich-205	253	33	srebp1	srebp1	NOUN
biomedich-205	253	34	and	and	CCONJ
biomedich-205	253	35	srebp2	srebp2	PROPN
biomedich-205	253	36	,	,	PUNCT
biomedich-205	253	37	128	128	NUM
biomedich-205	253	38	biology	biology	NOUN
biomedich-205	253	39	,	,	PUNCT
biomedich-205	253	40	medicine	medicine	NOUN
biomedich-205	253	41	,	,	PUNCT
biomedich-205	253	42	&	&	CCONJ
biomedich-205	253	43	natural	natural	ADJ
biomedich-205	253	44	product	product	NOUN
biomedich-205	253	45	chemistry	chemistry	NOUN
biomedich-205	253	46	11	11	NUM
biomedich-205	253	47	(	(	PUNCT
biomedich-205	253	48	2	2	NUM
biomedich-205	253	49	)	)	PUNCT
biomedich-205	253	50	,	,	PUNCT
biomedich-205	253	51	2022	2022	NUM
biomedich-205	253	52	:	:	PUNCT
biomedich-205	253	53	119	119	NUM
biomedich-205	253	54	-	-	SYM
biomedich-205	253	55	131	131	NUM
biomedich-205	253	56	and	and	CCONJ
biomedich-205	253	57	plasma	plasma	NOUN
biomedich-205	253	58	levels	level	NOUN
biomedich-205	253	59	.	.	PUNCT
biomedich-205	254	1	the	the	DET
biomedich-205	254	2	effect	effect	NOUN
biomedich-205	254	3	of	of	ADP
biomedich-205	254	4	ldlc	ldlc	NOUN
biomedich-205	254	5	on	on	ADP
biomedich-205	254	6	reducing	reduce	VERB
biomedich-205	254	7	the	the	DET
biomedich-205	254	8	risk	risk	NOUN
biomedich-205	254	9	of	of	ADP
biomedich-205	254	10	cardiovascular	cardiovascular	ADJ
biomedich-205	254	11	disease	disease	NOUN
biomedich-205	254	12	has	have	AUX
biomedich-205	254	13	been	be	AUX
biomedich-205	254	14	suggested	suggest	VERB
biomedich-205	254	15	to	to	PART
biomedich-205	254	16	reduce	reduce	VERB
biomedich-205	254	17	(	(	PUNCT
biomedich-205	254	18	bawazeer	bawazeer	NOUN
biomedich-205	254	19	et	et	NOUN
biomedich-205	254	20	al	al	PROPN
biomedich-205	254	21	.	.	PROPN
biomedich-205	254	22	,	,	PUNCT
biomedich-205	254	23	2016	2016	NUM
biomedich-205	254	24	)	)	PUNCT
biomedich-205	254	25	.	.	PUNCT
biomedich-205	255	1	in	in	ADP
biomedich-205	255	2	addition	addition	NOUN
biomedich-205	255	3	,	,	PUNCT
biomedich-205	255	4	studies	study	NOUN
biomedich-205	255	5	suggest	suggest	VERB
biomedich-205	255	6	that	that	SCONJ
biomedich-205	255	7	activation	activation	NOUN
biomedich-205	255	8	of	of	ADP
biomedich-205	255	9	srebp2	srebp2	PROPN
biomedich-205	255	10	causes	cause	VERB
biomedich-205	255	11	co	co	NOUN
biomedich-205	255	12	-	-	NOUN
biomedich-205	255	13	expression	expression	NOUN
biomedich-205	255	14	of	of	ADP
biomedich-205	255	15	pcsk9	pcsk9	NOUN
biomedich-205	255	16	and	and	CCONJ
biomedich-205	255	17	ldlr	ldlr	ADJ
biomedich-205	255	18	,	,	PUNCT
biomedich-205	255	19	leading	lead	VERB
biomedich-205	255	20	to	to	ADP
biomedich-205	255	21	ldlr	ldlr	ADJ
biomedich-205	255	22	depletion	depletion	NOUN
biomedich-205	255	23	and	and	CCONJ
biomedich-205	255	24	increased	increase	VERB
biomedich-205	255	25	ldlc	ldlc	NOUN
biomedich-205	255	26	circulation	circulation	NOUN
biomedich-205	255	27	(	(	PUNCT
biomedich-205	255	28	maxwell	maxwell	PROPN
biomedich-205	255	29	et	et	PROPN
biomedich-205	255	30	al	al	PROPN
biomedich-205	255	31	.	.	PROPN
biomedich-205	255	32	,	,	PUNCT
biomedich-205	255	33	2003	2003	NUM
biomedich-205	255	34	;	;	PUNCT
biomedich-205	255	35	urban	urban	PROPN
biomedich-205	255	36	et	et	PROPN
biomedich-205	255	37	al	al	PROPN
biomedich-205	255	38	.	.	PROPN
biomedich-205	255	39	,	,	PUNCT
biomedich-205	255	40	2013	2013	NUM
biomedich-205	255	41	)	)	PUNCT
biomedich-205	255	42	.	.	PUNCT
biomedich-205	256	1	as	as	ADP
biomedich-205	256	2	a	a	DET
biomedich-205	256	3	result	result	NOUN
biomedich-205	256	4	,	,	PUNCT
biomedich-205	256	5	the	the	DET
biomedich-205	256	6	effects	effect	NOUN
biomedich-205	256	7	of	of	ADP
biomedich-205	256	8	hesperetin	hesperetin	NOUN
biomedich-205	256	9	can	can	AUX
biomedich-205	256	10	be	be	AUX
biomedich-205	256	11	counteracted	counteract	VERB
biomedich-205	256	12	.	.	PUNCT
biomedich-205	257	1	studies	study	NOUN
biomedich-205	257	2	show	show	VERB
biomedich-205	257	3	that	that	SCONJ
biomedich-205	257	4	saturation	saturation	NOUN
biomedich-205	257	5	increases	increase	VERB
biomedich-205	257	6	with	with	ADP
biomedich-205	257	7	increasing	increase	VERB
biomedich-205	257	8	fsp3	fsp3	ADJ
biomedich-205	257	9	levels	level	NOUN
biomedich-205	257	10	(	(	PUNCT
biomedich-205	257	11	lovering	lovere	VERB
biomedich-205	257	12	et	et	PROPN
biomedich-205	257	13	al	al	PROPN
biomedich-205	257	14	.	.	PROPN
biomedich-205	257	15	,	,	PUNCT
biomedich-205	257	16	2009	2009	NUM
biomedich-205	257	17	;	;	PUNCT
biomedich-205	257	18	wei	wei	PROPN
biomedich-205	257	19	et	et	PROPN
biomedich-205	257	20	al	al	PROPN
biomedich-205	257	21	.	.	PROPN
biomedich-205	257	22	,	,	PUNCT
biomedich-205	257	23	2020	2020	NUM
biomedich-205	257	24	)	)	PUNCT
biomedich-205	257	25	.	.	PUNCT
biomedich-205	258	1	the	the	DET
biomedich-205	258	2	relationship	relationship	NOUN
biomedich-205	258	3	between	between	ADP
biomedich-205	258	4	fsp3	fsp3	ADJ
biomedich-205	258	5	and	and	CCONJ
biomedich-205	258	6	the	the	DET
biomedich-205	258	7	solubility	solubility	NOUN
biomedich-205	258	8	and	and	CCONJ
biomedich-205	258	9	melting	melting	NOUN
biomedich-205	258	10	point	point	NOUN
biomedich-205	258	11	attributes	attribute	NOUN
biomedich-205	258	12	of	of	ADP
biomedich-205	258	13	1000	1000	NUM
biomedich-205	258	14	compounds	compound	NOUN
biomedich-205	258	15	in	in	ADP
biomedich-205	258	16	the	the	DET
biomedich-205	258	17	dataset	dataset	NOUN
biomedich-205	258	18	showed	show	VERB
biomedich-205	258	19	a	a	DET
biomedich-205	258	20	positive	positive	ADJ
biomedich-205	258	21	correlation	correlation	NOUN
biomedich-205	258	22	between	between	ADP
biomedich-205	258	23	fsp3	fsp3	ADJ
biomedich-205	258	24	and	and	CCONJ
biomedich-205	258	25	solubility	solubility	NOUN
biomedich-205	258	26	and	and	CCONJ
biomedich-205	258	27	a	a	DET
biomedich-205	258	28	negative	negative	ADJ
biomedich-205	258	29	correlation	correlation	NOUN
biomedich-205	258	30	with	with	ADP
biomedich-205	258	31	melting	melting	NOUN
biomedich-205	258	32	point	point	NOUN
biomedich-205	258	33	(	(	PUNCT
biomedich-205	258	34	lovering	lovere	VERB
biomedich-205	258	35	et	et	PROPN
biomedich-205	258	36	al	al	PROPN
biomedich-205	258	37	.	.	PROPN
biomedich-205	258	38	,	,	PUNCT
biomedich-205	258	39	2009	2009	NUM
biomedich-205	258	40	)	)	PUNCT
biomedich-205	258	41	.	.	PUNCT
biomedich-205	259	1	compounds	compound	VERB
biomedich-205	259	2	with	with	ADP
biomedich-205	259	3	a	a	DET
biomedich-205	259	4	lower	low	ADJ
biomedich-205	259	5	melting	melting	NOUN
biomedich-205	259	6	point	point	NOUN
biomedich-205	259	7	show	show	VERB
biomedich-205	259	8	better	well	ADJ
biomedich-205	259	9	absorption	absorption	NOUN
biomedich-205	259	10	than	than	ADP
biomedich-205	259	11	compounds	compound	NOUN
biomedich-205	259	12	with	with	ADP
biomedich-205	259	13	a	a	DET
biomedich-205	259	14	higher	high	ADJ
biomedich-205	259	15	melting	melting	NOUN
biomedich-205	259	16	point	point	NOUN
biomedich-205	259	17	(	(	PUNCT
biomedich-205	259	18	chu	chu	PROPN
biomedich-205	259	19	&	&	CCONJ
biomedich-205	259	20	yalkowsky	yalkowsky	PROPN
biomedich-205	259	21	,	,	PUNCT
biomedich-205	259	22	2009	2009	NUM
biomedich-205	259	23	)	)	PUNCT
biomedich-205	259	24	.	.	PUNCT
biomedich-205	260	1	therefore	therefore	ADV
biomedich-205	260	2	,	,	PUNCT
biomedich-205	260	3	low	low	ADJ
biomedich-205	260	4	chemical	chemical	NOUN
biomedich-205	260	5	saturation	saturation	NOUN
biomedich-205	260	6	(	(	PUNCT
biomedich-205	260	7	fsp3	fsp3	ADJ
biomedich-205	260	8	)	)	PUNCT
biomedich-205	260	9	can	can	AUX
biomedich-205	260	10	lead	lead	VERB
biomedich-205	260	11	to	to	ADP
biomedich-205	260	12	high	high	ADJ
biomedich-205	260	13	melting	melting	NOUN
biomedich-205	260	14	points	point	NOUN
biomedich-205	260	15	,	,	PUNCT
biomedich-205	260	16	limited	limited	ADJ
biomedich-205	260	17	drug	drug	NOUN
biomedich-205	260	18	absorption	absorption	NOUN
biomedich-205	260	19	,	,	PUNCT
biomedich-205	260	20	and	and	CCONJ
biomedich-205	260	21	reduced	reduce	VERB
biomedich-205	260	22	oral	oral	ADJ
biomedich-205	260	23	bioavailability	bioavailability	NOUN
biomedich-205	260	24	.	.	PUNCT
biomedich-205	261	1	therefore	therefore	ADV
biomedich-205	261	2	,	,	PUNCT
biomedich-205	261	3	it	it	PRON
biomedich-205	261	4	is	be	AUX
biomedich-205	261	5	assumed	assume	VERB
biomedich-205	261	6	that	that	SCONJ
biomedich-205	261	7	low	low	ADJ
biomedich-205	261	8	levels	level	NOUN
biomedich-205	261	9	of	of	ADP
biomedich-205	261	10	hesperetin	hesperetin	NOUN
biomedich-205	261	11	saturation	saturation	NOUN
biomedich-205	261	12	(	(	PUNCT
biomedich-205	261	13	table	table	NOUN
biomedich-205	261	14	3	3	NUM
biomedich-205	261	15	)	)	PUNCT
biomedich-205	261	16	reduce	reduce	VERB
biomedich-205	261	17	oral	oral	ADJ
biomedich-205	261	18	bioavailability	bioavailability	NOUN
biomedich-205	261	19	.	.	PUNCT
biomedich-205	262	1	although	although	SCONJ
biomedich-205	262	2	various	various	ADJ
biomedich-205	262	3	studies	study	NOUN
biomedich-205	262	4	have	have	AUX
biomedich-205	262	5	shown	show	VERB
biomedich-205	262	6	that	that	SCONJ
biomedich-205	262	7	hesperetin	hesperetin	NOUN
biomedich-205	262	8	has	have	VERB
biomedich-205	262	9	low	low	ADJ
biomedich-205	262	10	oral	oral	ADJ
biomedich-205	262	11	bioavailability	bioavailability	NOUN
biomedich-205	262	12	(	(	PUNCT
biomedich-205	262	13	kanaze	kanaze	NOUN
biomedich-205	262	14	et	et	PROPN
biomedich-205	262	15	al	al	PROPN
biomedich-205	262	16	.	.	PROPN
biomedich-205	262	17	,	,	PUNCT
biomedich-205	262	18	2007	2007	NUM
biomedich-205	262	19	;	;	PUNCT
biomedich-205	262	20	liu	liu	PROPN
biomedich-205	262	21	&	&	CCONJ
biomedich-205	262	22	chen	chen	PROPN
biomedich-205	262	23	,	,	PUNCT
biomedich-205	262	24	2008	2008	NUM
biomedich-205	262	25	)	)	PUNCT
biomedich-205	262	26	,	,	PUNCT
biomedich-205	262	27	it	it	PRON
biomedich-205	262	28	is	be	AUX
biomedich-205	262	29	possible	possible	ADJ
biomedich-205	262	30	to	to	PART
biomedich-205	262	31	increase	increase	VERB
biomedich-205	262	32	oral	oral	ADJ
biomedich-205	262	33	bioavailability	bioavailability	NOUN
biomedich-205	262	34	by	by	ADP
biomedich-205	262	35	specific	specific	ADJ
biomedich-205	262	36	chemical	chemical	NOUN
biomedich-205	262	37	approaches	approach	NOUN
biomedich-205	262	38	[	[	X
biomedich-205	262	39	69	69	NUM
biomedich-205	262	40	]	]	PUNCT
biomedich-205	262	41	.	.	PUNCT
biomedich-205	263	1	(	(	PUNCT
biomedich-205	263	2	s	s	X
biomedich-205	263	3	)	)	PUNCT
biomedich-205	263	4	and	and	CCONJ
biomedich-205	263	5	(	(	PUNCT
biomedich-205	263	6	r	r	NOUN
biomedich-205	263	7	)	)	PUNCT
biomedich-205	263	8	canadins	canadin	NOUN
biomedich-205	263	9	have	have	VERB
biomedich-205	263	10	unique	unique	ADJ
biomedich-205	263	11	bioavailability	bioavailability	NOUN
biomedich-205	263	12	properties	property	NOUN
biomedich-205	263	13	due	due	ADJ
biomedich-205	263	14	to	to	ADP
biomedich-205	263	15	their	their	PRON
biomedich-205	263	16	ability	ability	NOUN
biomedich-205	263	17	to	to	PART
biomedich-205	263	18	efficiently	efficiently	ADV
biomedich-205	263	19	cross	cross	VERB
biomedich-205	263	20	the	the	DET
biomedich-205	263	21	blood	blood	NOUN
biomedich-205	263	22	-	-	PUNCT
biomedich-205	263	23	brain	brain	NOUN
biomedich-205	263	24	barrier	barrier	NOUN
biomedich-205	263	25	(	(	PUNCT
biomedich-205	263	26	bbb	bbb	NOUN
biomedich-205	263	27	)	)	PUNCT
biomedich-205	263	28	and	and	CCONJ
biomedich-205	263	29	reach	reach	VERB
biomedich-205	263	30	their	their	PRON
biomedich-205	263	31	targets	target	NOUN
biomedich-205	263	32	(	(	PUNCT
biomedich-205	263	33	table	table	NOUN
biomedich-205	263	34	3	3	NUM
biomedich-205	263	35	)	)	PUNCT
biomedich-205	263	36	.	.	PUNCT
biomedich-205	264	1	their	their	PRON
biomedich-205	264	2	high	high	ADJ
biomedich-205	264	3	gastrointestinal	gastrointestinal	ADJ
biomedich-205	264	4	absorption	absorption	NOUN
biomedich-205	264	5	and	and	CCONJ
biomedich-205	264	6	ability	ability	NOUN
biomedich-205	264	7	to	to	PART
biomedich-205	264	8	bind	bind	VERB
biomedich-205	264	9	to	to	ADP
biomedich-205	264	10	pgp	pgp	NOUN
biomedich-205	264	11	make	make	VERB
biomedich-205	264	12	these	these	DET
biomedich-205	264	13	molecules	molecule	NOUN
biomedich-205	264	14	excellent	excellent	ADJ
biomedich-205	264	15	candidates	candidate	NOUN
biomedich-205	264	16	for	for	ADP
biomedich-205	264	17	orally	orally	ADV
biomedich-205	264	18	administrable	administrable	ADJ
biomedich-205	264	19	drugs	drug	NOUN
biomedich-205	264	20	(	(	PUNCT
biomedich-205	264	21	laskowski	laskowski	NOUN
biomedich-205	264	22	et	et	PROPN
biomedich-205	264	23	al	al	PROPN
biomedich-205	264	24	.	.	PROPN
biomedich-205	264	25	,	,	PUNCT
biomedich-205	264	26	2018	2018	NUM
biomedich-205	264	27	)	)	PUNCT
biomedich-205	264	28	.	.	PUNCT
biomedich-205	265	1	based	base	VERB
biomedich-205	265	2	on	on	ADP
biomedich-205	265	3	current	current	ADJ
biomedich-205	265	4	research	research	NOUN
biomedich-205	265	5	,	,	PUNCT
biomedich-205	265	6	the	the	DET
biomedich-205	265	7	pharmacophore	pharmacophore	ADJ
biomedich-205	265	8	structure	structure	NOUN
biomedich-205	265	9	of	of	ADP
biomedich-205	265	10	(	(	PUNCT
biomedich-205	265	11	s	s	X
biomedich-205	265	12	)	)	PUNCT
biomedich-205	265	13	canadin	canadin	VERB
biomedich-205	265	14	may	may	AUX
biomedich-205	265	15	function	function	VERB
biomedich-205	265	16	as	as	ADP
biomedich-205	265	17	an	an	DET
biomedich-205	265	18	inhibitor	inhibitor	NOUN
biomedich-205	265	19	of	of	ADP
biomedich-205	265	20	the	the	DET
biomedich-205	265	21	pcsk9	pcsk9	NOUN
biomedich-205	265	22	protein	protein	NOUN
biomedich-205	265	23	molecule	molecule	NOUN
biomedich-205	265	24	.	.	PUNCT
biomedich-205	266	1	using	use	VERB
biomedich-205	266	2	existing	exist	VERB
biomedich-205	266	3	ace	ace	NOUN
biomedich-205	266	4	inhibitors	inhibitor	NOUN
biomedich-205	266	5	,	,	PUNCT
biomedich-205	266	6	pharmacophore	pharmacophore	NOUN
biomedich-205	266	7	was	be	AUX
biomedich-205	266	8	used	use	VERB
biomedich-205	266	9	as	as	ADP
biomedich-205	266	10	a	a	DET
biomedich-205	266	11	drug	drug	NOUN
biomedich-205	266	12	discovery	discovery	NOUN
biomedich-205	266	13	method	method	NOUN
biomedich-205	266	14	to	to	PART
biomedich-205	266	15	identify	identify	VERB
biomedich-205	266	16	new	new	ADJ
biomedich-205	266	17	pcsk9	pcsk9	NOUN
biomedich-205	266	18	inhibitors	inhibitor	NOUN
biomedich-205	266	19	.	.	PUNCT
biomedich-205	267	1	a	a	DET
biomedich-205	267	2	literature	literature	NOUN
biomedich-205	267	3	search	search	NOUN
biomedich-205	267	4	was	be	AUX
biomedich-205	267	5	conducted	conduct	VERB
biomedich-205	267	6	to	to	PART
biomedich-205	267	7	identify	identify	VERB
biomedich-205	267	8	the	the	DET
biomedich-205	267	9	optimal	optimal	ADJ
biomedich-205	267	10	structure	structure	NOUN
biomedich-205	267	11	of	of	ADP
biomedich-205	267	12	pcsk9	pcsk9	PROPN
biomedich-205	267	13	and	and	CCONJ
biomedich-205	267	14	the	the	DET
biomedich-205	267	15	active	active	ADJ
biomedich-205	267	16	site	site	NOUN
biomedich-205	267	17	of	of	ADP
biomedich-205	267	18	known	know	VERB
biomedich-205	267	19	ace	ace	NOUN
biomedich-205	267	20	inhibitors	inhibitor	NOUN
biomedich-205	267	21	.	.	PUNCT
biomedich-205	268	1	the	the	DET
biomedich-205	268	2	results	result	NOUN
biomedich-205	268	3	of	of	ADP
biomedich-205	268	4	molecular	molecular	ADJ
biomedich-205	268	5	docking	docking	NOUN
biomedich-205	268	6	,	,	PUNCT
biomedich-205	268	7	incorporating	incorporate	VERB
biomedich-205	268	8	a	a	DET
biomedich-205	268	9	computational	computational	ADJ
biomedich-205	268	10	and	and	CCONJ
biomedich-205	268	11	unbiased	unbiased	ADJ
biomedich-205	268	12	approach	approach	NOUN
biomedich-205	268	13	,	,	PUNCT
biomedich-205	268	14	highlighted	highlight	VERB
biomedich-205	268	15	the	the	DET
biomedich-205	268	16	relevance	relevance	NOUN
biomedich-205	268	17	of	of	ADP
biomedich-205	268	18	drug	drug	NOUN
biomedich-205	268	19	development	development	NOUN
biomedich-205	268	20	in	in	ADP
biomedich-205	268	21	atherosclerosis	atherosclerosis	NOUN
biomedich-205	268	22	.	.	PUNCT
biomedich-205	269	1	in	in	ADP
biomedich-205	269	2	this	this	DET
biomedich-205	269	3	study	study	NOUN
biomedich-205	269	4	,	,	PUNCT
biomedich-205	269	5	the	the	DET
biomedich-205	269	6	binding	bind	VERB
biomedich-205	269	7	affinities	affinity	NOUN
biomedich-205	269	8	were	be	AUX
biomedich-205	269	9	analyzed	analyze	VERB
biomedich-205	269	10	and	and	CCONJ
biomedich-205	269	11	the	the	DET
biomedich-205	269	12	molecules	molecule	NOUN
biomedich-205	269	13	with	with	ADP
biomedich-205	269	14	the	the	DET
biomedich-205	269	15	highest	high	ADJ
biomedich-205	269	16	affinities	affinity	NOUN
biomedich-205	269	17	for	for	ADP
biomedich-205	269	18	the	the	DET
biomedich-205	269	19	target	target	NOUN
biomedich-205	269	20	of	of	ADP
biomedich-205	269	21	atherosclerosis	atherosclerosis	NOUN
biomedich-205	269	22	were	be	AUX
biomedich-205	269	23	zinc000073	zinc000073	NOUN
biomedich-205	269	24	,	,	PUNCT
biomedich-205	269	25	zinc00020260	zinc00020260	PROPN
biomedich-205	269	26	,	,	PUNCT
biomedich-205	269	27	zinc00033518	zinc00033518	PROPN
biomedich-205	269	28	,	,	PUNCT
biomedich-205	269	29	zinc00001875	zinc00001875	PROPN
biomedich-205	269	30	,	,	PUNCT
biomedich-205	269	31	zinc00003742	zinc00003742	PROPN
biomedich-205	269	32	,	,	PUNCT
biomedich-205	269	33	zinc0003517	zinc0003517	PROPN
biomedich-205	269	34	,	,	PUNCT
biomedich-205	269	35	zinc000390	zinc000390	PROPN
biomedich-205	269	36	,	,	PUNCT
biomedich-205	269	37	zinc000390	zinc000390	PROPN
biomedich-205	269	38	,	,	PUNCT
biomedich-205	269	39	zinc0003900	zinc0003900	PROPN
biomedich-205	269	40	,	,	PUNCT
biomedich-205	269	41	zinc0000390	zinc0000390	PROPN
biomedich-205	269	42	,	,	PUNCT
biomedich-205	269	43	zinc000390	zinc000390	PROPN
biomedich-205	269	44	,	,	PUNCT
biomedich-205	269	45	zinc000390	zinc000390	PROPN
biomedich-205	269	46	,	,	PUNCT
biomedich-205	269	47	zinc000390	zinc000390	PROPN
biomedich-205	269	48	,	,	PUNCT
biomedich-205	269	49	zinc0003900	zinc0003900	PROPN
biomedich-205	269	50	,	,	PUNCT
biomedich-205	269	51	zinc0003900	zinc0003900	PROPN
biomedich-205	269	52	,	,	PUNCT
biomedich-205	269	53	zinc0003900	zinc0003900	PROPN
biomedich-205	269	54	,	,	PUNCT
biomedich-205	269	55	zinc0003900	zinc0003900	PROPN
biomedich-205	269	56	,	,	PUNCT
biomedich-205	269	57	zinc0003900	zinc0003900	PROPN
biomedich-205	269	58	,	,	PUNCT
biomedich-205	269	59	zinc0003900	zinc0003900	PROPN
biomedich-205	269	60	,	,	PUNCT
biomedich-205	269	61	zinc0003900	zinc0003900	PROPN
biomedich-205	269	62	,	,	PUNCT
biomedich-205	269	63	zinc0003900	zinc0003900	PROPN
biomedich-205	269	64	lipinski	lipinski	PROPN
biomedich-205	269	65	's	's	PART
biomedich-205	269	66	rule	rule	NOUN
biomedich-205	269	67	5	5	NUM
biomedich-205	269	68	was	be	AUX
biomedich-205	269	69	applied	apply	VERB
biomedich-205	269	70	and	and	CCONJ
biomedich-205	269	71	passed	pass	VERB
biomedich-205	269	72	for	for	ADP
biomedich-205	269	73	these	these	DET
biomedich-205	269	74	major	major	ADJ
biomedich-205	269	75	drug	drug	NOUN
biomedich-205	269	76	candidates	candidate	NOUN
biomedich-205	269	77	.	.	PUNCT
biomedich-205	270	1	several	several	ADJ
biomedich-205	270	2	molecules	molecule	NOUN
biomedich-205	270	3	from	from	ADP
biomedich-205	270	4	virtual	virtual	ADJ
biomedich-205	270	5	screening	screening	NOUN
biomedich-205	270	6	and	and	CCONJ
biomedich-205	270	7	drug	drug	NOUN
biomedich-205	270	8	database	database	NOUN
biomedich-205	270	9	searches	search	NOUN
biomedich-205	270	10	were	be	AUX
biomedich-205	270	11	found	find	VERB
biomedich-205	270	12	as	as	ADP
biomedich-205	270	13	herbal	herbal	ADJ
biomedich-205	270	14	chemicals	chemical	NOUN
biomedich-205	270	15	such	such	ADJ
biomedich-205	270	16	as	as	ADP
biomedich-205	270	17	(	(	PUNCT
biomedich-205	270	18	s	s	NOUN
biomedich-205	270	19	)	)	PUNCT
biomedich-205	270	20	canadine	canadine	NOUN
biomedich-205	270	21	,	,	PUNCT
biomedich-205	270	22	hesperetin	hesperetin	NOUN
biomedich-205	270	23	,	,	PUNCT
biomedich-205	270	24	or	or	CCONJ
biomedich-205	270	25	the	the	DET
biomedich-205	270	26	antihypertensive	antihypertensive	ADJ
biomedich-205	270	27	drug	drug	NOUN
biomedich-205	270	28	labetalol	labetalol	NOUN
biomedich-205	270	29	.	.	PUNCT
biomedich-205	271	1	the	the	DET
biomedich-205	271	2	formation	formation	NOUN
biomedich-205	271	3	of	of	ADP
biomedich-205	271	4	stable	stable	ADJ
biomedich-205	271	5	protein	protein	NOUN
biomedich-205	271	6	-	-	PUNCT
biomedich-205	271	7	ligand	ligand	NOUN
biomedich-205	271	8	complexes	complex	NOUN
biomedich-205	271	9	by	by	ADP
biomedich-205	271	10	these	these	DET
biomedich-205	271	11	chemicals	chemical	NOUN
biomedich-205	271	12	has	have	AUX
biomedich-205	271	13	been	be	AUX
biomedich-205	271	14	demonstrated	demonstrate	VERB
biomedich-205	271	15	using	use	VERB
biomedich-205	271	16	molecular	molecular	ADJ
biomedich-205	271	17	dynamics	dynamic	NOUN
biomedich-205	271	18	.	.	PUNCT
biomedich-205	272	1	for	for	ADP
biomedich-205	272	2	(	(	PUNCT
biomedich-205	272	3	s	s	NOUN
biomedich-205	272	4	)	)	PUNCT
biomedich-205	272	5	canadine	canadine	NOUN
biomedich-205	272	6	,	,	PUNCT
biomedich-205	272	7	the	the	DET
biomedich-205	272	8	complex	complex	NOUN
biomedich-205	272	9	prepared	prepare	VERB
biomedich-205	272	10	with	with	ADP
biomedich-205	272	11	this	this	DET
biomedich-205	272	12	chemical	chemical	NOUN
biomedich-205	272	13	is	be	AUX
biomedich-205	272	14	the	the	DET
biomedich-205	272	15	most	most	ADV
biomedich-205	272	16	stable	stable	ADJ
biomedich-205	272	17	in	in	ADP
biomedich-205	272	18	molecular	molecular	ADJ
biomedich-205	272	19	dynamics	dynamic	NOUN
biomedich-205	272	20	and	and	CCONJ
biomedich-205	272	21	has	have	VERB
biomedich-205	272	22	the	the	DET
biomedich-205	272	23	lowest	low	ADJ
biomedich-205	272	24	rmsd	rmsd	NOUN
biomedich-205	272	25	.	.	PUNCT
biomedich-205	273	1	conclusions	conclusion	NOUN
biomedich-205	273	2	the	the	DET
biomedich-205	273	3	pcsk9	pcsk9	NOUN
biomedich-205	273	4	inhibitors	inhibitor	NOUN
biomedich-205	273	5	are	be	AUX
biomedich-205	273	6	found	find	VERB
biomedich-205	273	7	through	through	ADP
biomedich-205	273	8	the	the	DET
biomedich-205	273	9	computational	computational	ADJ
biomedich-205	273	10	methods	method	NOUN
biomedich-205	273	11	,	,	PUNCT
biomedich-205	273	12	these	these	DET
biomedich-205	273	13	inhibitors	inhibitor	NOUN
biomedich-205	273	14	can	can	AUX
biomedich-205	273	15	be	be	AUX
biomedich-205	273	16	used	use	VERB
biomedich-205	273	17	as	as	ADP
biomedich-205	273	18	a	a	DET
biomedich-205	273	19	vital	vital	ADJ
biomedich-205	273	20	target	target	NOUN
biomedich-205	273	21	for	for	ADP
biomedich-205	273	22	the	the	DET
biomedich-205	273	23	novel	novel	ADJ
biomedich-205	273	24	drug	drug	NOUN
biomedich-205	273	25	screening	screening	NOUN
biomedich-205	273	26	and	and	CCONJ
biomedich-205	273	27	discovery	discovery	NOUN
biomedich-205	273	28	for	for	ADP
biomedich-205	273	29	atherosclerosis	atherosclerosis	NOUN
biomedich-205	273	30	in	in	ADP
biomedich-205	273	31	future	future	NOUN
biomedich-205	273	32	.	.	PUNCT
biomedich-205	274	1	the	the	DET
biomedich-205	274	2	computational	computational	ADJ
biomedich-205	274	3	findings	finding	NOUN
biomedich-205	274	4	should	should	AUX
biomedich-205	274	5	be	be	AUX
biomedich-205	274	6	conformed	conform	VERB
biomedich-205	274	7	in	in	ADP
biomedich-205	274	8	future	future	NOUN
biomedich-205	274	9	using	use	VERB
biomedich-205	274	10	invitro	invitro	ADJ
biomedich-205	274	11	and	and	CCONJ
biomedich-205	274	12	invivo	invivo	ADJ
biomedich-205	274	13	method	method	NOUN
biomedich-205	274	14	for	for	ADP
biomedich-205	274	15	further	further	ADJ
biomedich-205	274	16	understanding	understand	VERB
biomedich-205	274	17	the	the	DET
biomedich-205	274	18	inhibitors	inhibitor	NOUN
biomedich-205	274	19	role	role	NOUN
biomedich-205	274	20	in	in	ADP
biomedich-205	274	21	atherosclerosis	atherosclerosis	NOUN
biomedich-205	274	22	.	.	PUNCT
biomedich-205	275	1	hence	hence	ADV
biomedich-205	275	2	a	a	DET
biomedich-205	275	3	depth	depth	NOUN
biomedich-205	275	4	wet	wet	ADJ
biomedich-205	275	5	lab	lab	NOUN
biomedich-205	275	6	research	research	NOUN
biomedich-205	275	7	need	need	VERB
biomedich-205	275	8	to	to	PART
biomedich-205	275	9	be	be	AUX
biomedich-205	275	10	done	do	VERB
biomedich-205	275	11	with	with	ADP
biomedich-205	275	12	is	be	AUX
biomedich-205	275	13	inhibitors	inhibitor	NOUN
biomedich-205	275	14	as	as	ADP
biomedich-205	275	15	a	a	DET
biomedich-205	275	16	target	target	NOUN
biomedich-205	275	17	for	for	ADP
biomedich-205	275	18	treating	treat	VERB
biomedich-205	275	19	atherosclerosis	atherosclerosis	NOUN
biomedich-205	275	20	conflict	conflict	NOUN
biomedich-205	275	21	of	of	ADP
biomedich-205	275	22	interest	interest	NOUN
biomedich-205	275	23	:	:	PUNCT
biomedich-205	275	24	the	the	DET
biomedich-205	275	25	author	author	NOUN
biomedich-205	275	26	has	have	VERB
biomedich-205	275	27	no	no	DET
biomedich-205	275	28	relevant	relevant	ADJ
biomedich-205	275	29	financial	financial	ADJ
biomedich-205	275	30	or	or	CCONJ
biomedich-205	275	31	non	non	ADJ
biomedich-205	275	32	-	-	ADJ
biomedich-205	275	33	financial	financial	ADJ
biomedich-205	275	34	interests	interest	NOUN
biomedich-205	275	35	to	to	PART
biomedich-205	275	36	disclose	disclose	VERB
biomedich-205	275	37	.	.	PUNCT
biomedich-205	276	1	code	code	NOUN
biomedich-205	276	2	availability	availability	NOUN
biomedich-205	276	3	:	:	PUNCT
biomedich-205	276	4	no	no	DET
biomedich-205	276	5	code	code	NOUN
biomedich-205	276	6	availability	availability	NOUN
biomedich-205	276	7	data	datum	NOUN
biomedich-205	276	8	availability	availability	NOUN
biomedich-205	276	9	:	:	PUNCT
biomedich-205	276	10	data	datum	NOUN
biomedich-205	276	11	sharing	share	VERB
biomedich-205	276	12	not	not	PART
biomedich-205	276	13	applicable	applicable	ADJ
biomedich-205	276	14	to	to	ADP
biomedich-205	276	15	this	this	DET
biomedich-205	276	16	article	article	NOUN
biomedich-205	276	17	as	as	SCONJ
biomedich-205	276	18	no	no	DET
biomedich-205	276	19	datasets	dataset	NOUN
biomedich-205	276	20	were	be	AUX
biomedich-205	276	21	generated	generate	VERB
biomedich-205	276	22	or	or	CCONJ
biomedich-205	276	23	analysed	analyse	VERB
biomedich-205	276	24	during	during	ADP
biomedich-205	276	25	the	the	DET
biomedich-205	276	26	current	current	ADJ
biomedich-205	276	27	study	study	NOUN
biomedich-205	276	28	.	.	PUNCT
biomedich-205	277	1	authors	author	NOUN
biomedich-205	277	2	’	'	PUNCT
biomedich-205	277	3	contribution	contribution	NOUN
biomedich-205	277	4	:	:	PUNCT
biomedich-205	277	5	first	first	ADJ
biomedich-205	277	6	author	author	NOUN
biomedich-205	277	7	s	s	PART
biomedich-205	277	8	sabarinathan	sabarinathan	NOUN
biomedich-205	277	9	and	and	CCONJ
biomedich-205	277	10	second	second	ADJ
biomedich-205	277	11	author	author	NOUN
biomedich-205	277	12	revathy	revathy	NOUN
biomedich-205	277	13	l	l	NOUN
biomedich-205	277	14	r	r	NOUN
biomedich-205	277	15	have	have	AUX
biomedich-205	277	16	contributed	contribute	VERB
biomedich-205	277	17	in	in	ADP
biomedich-205	277	18	all	all	DET
biomedich-205	277	19	aspects	aspect	NOUN
biomedich-205	277	20	for	for	ADP
biomedich-205	277	21	the	the	DET
biomedich-205	277	22	prepration	prepration	NOUN
biomedich-205	277	23	of	of	ADP
biomedich-205	277	24	manuscript	manuscript	NOUN
biomedich-205	277	25	and	and	CCONJ
biomedich-205	277	26	generation	generation	NOUN
biomedich-205	277	27	of	of	ADP
biomedich-205	277	28	idea	idea	NOUN
biomedich-205	277	29	under	under	ADP
biomedich-205	277	30	the	the	DET
biomedich-205	277	31	guidance	guidance	NOUN
biomedich-205	277	32	of	of	ADP
biomedich-205	277	33	dr	dr	PROPN
biomedich-205	277	34	r	r	PROPN
biomedich-205	277	35	janet	janet	PROPN
biomedich-205	277	36	rani	rani	PROPN
biomedich-205	277	37	(	(	PUNCT
biomedich-205	277	38	corresponding	correspond	VERB
biomedich-205	277	39	author	author	NOUN
biomedich-205	277	40	)	)	PUNCT
biomedich-205	277	41	competing	compete	VERB
biomedich-205	277	42	interests	interest	NOUN
biomedich-205	277	43	:	:	PUNCT
biomedich-205	277	44	the	the	DET
biomedich-205	277	45	author	author	NOUN
biomedich-205	277	46	declares	declare	VERB
biomedich-205	277	47	there	there	PRON
biomedich-205	277	48	is	be	VERB
biomedich-205	277	49	no	no	DET
biomedich-205	277	50	competing	compete	VERB
biomedich-205	277	51	interest	interest	NOUN
biomedich-205	277	52	funding	funding	NOUN
biomedich-205	277	53	:	:	PUNCT
biomedich-205	277	54	no	no	DET
biomedich-205	277	55	funding	funding	NOUN
biomedich-205	277	56	was	be	AUX
biomedich-205	277	57	received	receive	VERB
biomedich-205	277	58	to	to	PART
biomedich-205	277	59	assist	assist	VERB
biomedich-205	277	60	with	with	ADP
biomedich-205	277	61	the	the	DET
biomedich-205	277	62	preparation	preparation	NOUN
biomedich-205	277	63	of	of	ADP
biomedich-205	277	64	this	this	DET
biomedich-205	277	65	manuscript	manuscript	NOUN
biomedich-205	277	66	references	reference	NOUN
biomedich-205	277	67	abraham	abraham	PROPN
biomedich-205	277	68	,	,	PUNCT
biomedich-205	277	69	m.	m.	PROPN
biomedich-205	277	70	j.	j.	PROPN
biomedich-205	277	71	,	,	PUNCT
biomedich-205	277	72	murtola	murtola	PROPN
biomedich-205	277	73	,	,	PUNCT
biomedich-205	277	74	t.	t.	PROPN
biomedich-205	277	75	,	,	PUNCT
biomedich-205	277	76	schulz	schulz	PROPN
biomedich-205	277	77	,	,	PUNCT
biomedich-205	277	78	r.	r.	PROPN
biomedich-205	277	79	,	,	PUNCT
biomedich-205	277	80	páll	páll	PROPN
biomedich-205	277	81	,	,	PUNCT
biomedich-205	277	82	s.	s.	PROPN
biomedich-205	277	83	,	,	PUNCT
biomedich-205	277	84	smith	smith	PROPN
biomedich-205	277	85	,	,	PUNCT
biomedich-205	277	86	j.	j.	PROPN
biomedich-205	277	87	c.	c.	PROPN
biomedich-205	277	88	,	,	PUNCT
biomedich-205	277	89	hess	hess	PROPN
biomedich-205	277	90	,	,	PUNCT
biomedich-205	277	91	b.	b.	PROPN
biomedich-205	277	92	,	,	PUNCT
biomedich-205	277	93	&	&	CCONJ
biomedich-205	277	94	lindah	lindah	PROPN
biomedich-205	277	95	,	,	PUNCT
biomedich-205	277	96	e.	e.	PROPN
biomedich-205	277	97	(	(	PUNCT
biomedich-205	277	98	2015	2015	NUM
biomedich-205	277	99	)	)	PUNCT
biomedich-205	277	100	.	.	PUNCT
biomedich-205	278	1	gromacs	gromacs	NOUN
biomedich-205	278	2	:	:	PUNCT
biomedich-205	278	3	high	high	ADJ
biomedich-205	278	4	performance	performance	NOUN
biomedich-205	278	5	molecular	molecular	ADJ
biomedich-205	278	6	simulations	simulation	NOUN
biomedich-205	278	7	through	through	ADP
biomedich-205	278	8	multi	multi	ADJ
biomedich-205	278	9	-	-	ADJ
biomedich-205	278	10	level	level	ADJ
biomedich-205	278	11	parallelism	parallelism	NOUN
biomedich-205	278	12	from	from	ADP
biomedich-205	278	13	laptops	laptop	NOUN
biomedich-205	278	14	to	to	ADP
biomedich-205	278	15	supercomputers	supercomputer	NOUN
biomedich-205	278	16	.	.	PUNCT
biomedich-205	279	1	softwarex	softwarex	PROPN
biomedich-205	279	2	,	,	PUNCT
biomedich-205	279	3	1–2	1–2	NUM
biomedich-205	279	4	,	,	PUNCT
biomedich-205	279	5	19–25	19–25	NUM
biomedich-205	279	6	.	.	PUNCT
biomedich-205	280	1	https://doi.org/10.1016/j.softx.2015.06.001	https://doi.org/10.1016/j.softx.2015.06.001	PROPN
biomedich-205	280	2	andreadou	andreadou	NOUN
biomedich-205	280	3	,	,	PUNCT
biomedich-205	280	4	i.	i.	NOUN
biomedich-205	280	5	,	,	PUNCT
biomedich-205	280	6	iliodromitis	iliodromitis	PROPN
biomedich-205	280	7	,	,	PUNCT
biomedich-205	280	8	e.	e.	PROPN
biomedich-205	280	9	k.	k.	PROPN
biomedich-205	280	10	,	,	PUNCT
biomedich-205	280	11	lazou	lazou	PROPN
biomedich-205	280	12	,	,	PUNCT
biomedich-205	280	13	a.	a.	NOUN
biomedich-205	280	14	,	,	PUNCT
biomedich-205	280	15	görbe	görbe	NOUN
biomedich-205	280	16	,	,	PUNCT
biomedich-205	280	17	a.	a.	NOUN
biomedich-205	280	18	,	,	PUNCT
biomedich-205	280	19	giricz	giricz	ADJ
biomedich-205	280	20	,	,	PUNCT
biomedich-205	280	21	z.	z.	PROPN
biomedich-205	280	22	,	,	PUNCT
biomedich-205	280	23	schulz	schulz	PROPN
biomedich-205	280	24	,	,	PUNCT
biomedich-205	280	25	r.	r.	PROPN
biomedich-205	280	26	,	,	PUNCT
biomedich-205	280	27	&	&	CCONJ
biomedich-205	280	28	ferdinandy	ferdinandy	PROPN
biomedich-205	280	29	,	,	PUNCT
biomedich-205	280	30	p.	p.	NOUN
biomedich-205	280	31	(	(	PUNCT
biomedich-205	280	32	2017	2017	NUM
biomedich-205	280	33	)	)	PUNCT
biomedich-205	280	34	.	.	PUNCT
biomedich-205	281	1	effect	effect	NOUN
biomedich-205	281	2	of	of	ADP
biomedich-205	281	3	hypercholesterolaemia	hypercholesterolaemia	NOUN
biomedich-205	281	4	on	on	ADP
biomedich-205	281	5	myocardial	myocardial	ADJ
biomedich-205	281	6	function	function	NOUN
biomedich-205	281	7	,	,	PUNCT
biomedich-205	281	8	ischaemia	ischaemia	PROPN
biomedich-205	281	9	–	–	PUNCT
biomedich-205	281	10	reperfusion	reperfusion	NOUN
biomedich-205	281	11	injury	injury	NOUN
biomedich-205	281	12	and	and	CCONJ
biomedich-205	281	13	cardioprotection	cardioprotection	NOUN
biomedich-205	281	14	by	by	ADP
biomedich-205	281	15	preconditioning	precondition	VERB
biomedich-205	281	16	,	,	PUNCT
biomedich-205	281	17	postconditioning	postconditione	VERB
biomedich-205	281	18	and	and	CCONJ
biomedich-205	281	19	remote	remote	ADJ
biomedich-205	281	20	conditioning	conditioning	NOUN
biomedich-205	281	21	.	.	PUNCT
biomedich-205	282	1	in	in	ADP
biomedich-205	282	2	british	british	ADJ
biomedich-205	282	3	journal	journal	PROPN
biomedich-205	282	4	of	of	ADP
biomedich-205	282	5	pharmacology	pharmacology	NOUN
biomedich-205	282	6	(	(	PUNCT
biomedich-205	282	7	vol	vol	NOUN
biomedich-205	282	8	.	.	NOUN
biomedich-205	282	9	174	174	NUM
biomedich-205	282	10	,	,	PUNCT
biomedich-205	282	11	issue	issue	NOUN
biomedich-205	282	12	12	12	NUM
biomedich-205	282	13	)	)	PUNCT
biomedich-205	282	14	.	.	PUNCT
biomedich-205	283	1	https://doi.org/10.1111/bph.13704	https://doi.org/10.1111/bph.13704	ADJ
biomedich-205	283	2	attique	attique	NOUN
biomedich-205	283	3	,	,	PUNCT
biomedich-205	283	4	s.	s.	PROPN
biomedich-205	283	5	a.	a.	PROPN
biomedich-205	283	6	,	,	PUNCT
biomedich-205	283	7	hassan	hassan	PROPN
biomedich-205	283	8	,	,	PUNCT
biomedich-205	283	9	m.	m.	NOUN
biomedich-205	283	10	,	,	PUNCT
biomedich-205	283	11	usman	usman	PROPN
biomedich-205	283	12	,	,	PUNCT
biomedich-205	283	13	m.	m.	NOUN
biomedich-205	283	14	,	,	PUNCT
biomedich-205	283	15	atif	atif	PROPN
biomedich-205	283	16	,	,	PUNCT
biomedich-205	283	17	r.	r.	PROPN
biomedich-205	283	18	m.	m.	PROPN
biomedich-205	283	19	,	,	PUNCT
biomedich-205	283	20	mahboob	mahboob	PROPN
biomedich-205	283	21	,	,	PUNCT
biomedich-205	283	22	s.	s.	PROPN
biomedich-205	283	23	,	,	PUNCT
biomedich-205	283	24	al	al	PROPN
biomedich-205	283	25	-	-	PUNCT
biomedich-205	283	26	ghanim	ghanim	PROPN
biomedich-205	283	27	,	,	PUNCT
biomedich-205	283	28	k.	k.	PROPN
biomedich-205	283	29	a.	a.	PROPN
biomedich-205	283	30	,	,	PUNCT
biomedich-205	283	31	bilal	bilal	PROPN
biomedich-205	283	32	,	,	PUNCT
biomedich-205	283	33	m.	m.	NOUN
biomedich-205	283	34	,	,	PUNCT
biomedich-205	283	35	&	&	CCONJ
biomedich-205	283	36	nawaz	nawaz	NOUN
biomedich-205	283	37	,	,	PUNCT
biomedich-205	283	38	m.	m.	NOUN
biomedich-205	283	39	z.	z.	PROPN
biomedich-205	283	40	(	(	PUNCT
biomedich-205	283	41	2019	2019	NUM
biomedich-205	283	42	)	)	PUNCT
biomedich-205	283	43	.	.	PUNCT
biomedich-205	284	1	a	a	DET
biomedich-205	284	2	molecular	molecular	ADJ
biomedich-205	284	3	docking	docking	NOUN
biomedich-205	284	4	approach	approach	NOUN
biomedich-205	284	5	to	to	PART
biomedich-205	284	6	evaluate	evaluate	VERB
biomedich-205	284	7	the	the	DET
biomedich-205	284	8	pharmacological	pharmacological	ADJ
biomedich-205	284	9	properties	property	NOUN
biomedich-205	284	10	of	of	ADP
biomedich-205	284	11	natural	natural	ADJ
biomedich-205	284	12	and	and	CCONJ
biomedich-205	284	13	synthetic	synthetic	ADJ
biomedich-205	284	14	treatment	treatment	NOUN
biomedich-205	284	15	candidates	candidate	NOUN
biomedich-205	284	16	for	for	ADP
biomedich-205	284	17	use	use	NOUN
biomedich-205	284	18	against	against	ADP
biomedich-205	284	19	hypertension	hypertension	NOUN
biomedich-205	284	20	.	.	PUNCT
biomedich-205	285	1	international	international	ADJ
biomedich-205	285	2	journal	journal	PROPN
biomedich-205	285	3	of	of	ADP
biomedich-205	285	4	sethuramalingam	sethuramalingam	PROPN
biomedich-205	285	5	et	et	PROPN
biomedich-205	285	6	al	al	PROPN
biomedich-205	285	7	.	.	PROPN
biomedich-205	285	8	–	–	PUNCT
biomedich-205	285	9	identification	identification	NOUN
biomedich-205	285	10	of	of	ADP
biomedich-205	285	11	pcsk9	pcsk9	NOUN
biomedich-205	285	12	inhibitors	inhibitor	VERB
biomedich-205	285	13	129	129	NUM
biomedich-205	285	14	environmental	environmental	ADJ
biomedich-205	285	15	research	research	NOUN
biomedich-205	285	16	and	and	CCONJ
biomedich-205	285	17	public	public	ADJ
biomedich-205	285	18	health	health	NOUN
biomedich-205	285	19	,	,	PUNCT
biomedich-205	285	20	16(6	16(6	NUM
biomedich-205	285	21	)	)	PUNCT
biomedich-205	285	22	,	,	PUNCT
biomedich-205	285	23	1–17	1–17	PROPN
biomedich-205	285	24	.	.	PUNCT
biomedich-205	286	1	https://doi.org/10.3390/ijerph16060923	https://doi.org/10.3390/ijerph16060923	PROPN
biomedich-205	286	2	bass	bass	PROPN
biomedich-205	286	3	,	,	PUNCT
biomedich-205	286	4	j.	j.	PROPN
biomedich-205	286	5	w.	w.	PROPN
biomedich-205	286	6	(	(	PUNCT
biomedich-205	286	7	1973	1973	NUM
biomedich-205	286	8	)	)	PUNCT
biomedich-205	286	9	.	.	PUNCT
biomedich-205	287	1	oral	oral	ADJ
biomedich-205	287	2	antipyretic	antipyretic	ADJ
biomedich-205	287	3	therapy	therapy	NOUN
biomedich-205	287	4	-	-	PUNCT
biomedich-205	287	5	reply	reply	NOUN
biomedich-205	287	6	.	.	PUNCT
biomedich-205	288	1	american	american	ADJ
biomedich-205	288	2	journal	journal	PROPN
biomedich-205	288	3	of	of	ADP
biomedich-205	288	4	diseases	disease	NOUN
biomedich-205	288	5	of	of	ADP
biomedich-205	288	6	children	child	NOUN
biomedich-205	288	7	,	,	PUNCT
biomedich-205	288	8	126(4	126(4	NUM
biomedich-205	288	9	)	)	PUNCT
biomedich-205	288	10	,	,	PUNCT
biomedich-205	288	11	564	564	NUM
biomedich-205	288	12	.	.	PUNCT
biomedich-205	289	1	https://doi.org/10.1001/archpedi.1973.02110190459029	https://doi.org/10.1001/archpedi.1973.02110190459029	PROPN
biomedich-205	289	2	bateman	bateman	PROPN
biomedich-205	289	3	,	,	PUNCT
biomedich-205	289	4	a.	a.	PROPN
biomedich-205	289	5	,	,	PUNCT
biomedich-205	289	6	martin	martin	PROPN
biomedich-205	289	7	,	,	PUNCT
biomedich-205	289	8	m.	m.	NOUN
biomedich-205	289	9	j.	j.	PROPN
biomedich-205	289	10	,	,	PUNCT
biomedich-205	289	11	o’donovan	o’donovan	PROPN
biomedich-205	289	12	,	,	PUNCT
biomedich-205	289	13	c.	c.	NOUN
biomedich-205	289	14	,	,	PUNCT
biomedich-205	289	15	magrane	magrane	NOUN
biomedich-205	289	16	,	,	PUNCT
biomedich-205	289	17	m.	m.	NOUN
biomedich-205	289	18	,	,	PUNCT
biomedich-205	289	19	apweiler	apweiler	PROPN
biomedich-205	289	20	,	,	PUNCT
biomedich-205	289	21	r.	r.	PROPN
biomedich-205	289	22	,	,	PUNCT
biomedich-205	289	23	alpi	alpi	PROPN
biomedich-205	289	24	,	,	PUNCT
biomedich-205	289	25	e.	e.	PROPN
biomedich-205	289	26	,	,	PUNCT
biomedich-205	289	27	antunes	antunes	PROPN
biomedich-205	289	28	,	,	PUNCT
biomedich-205	289	29	r.	r.	PROPN
biomedich-205	289	30	,	,	PUNCT
biomedich-205	289	31	arganiska	arganiska	NOUN
biomedich-205	289	32	,	,	PUNCT
biomedich-205	289	33	j.	j.	PROPN
biomedich-205	289	34	,	,	PUNCT
biomedich-205	289	35	bely	bely	ADV
biomedich-205	289	36	,	,	PUNCT
biomedich-205	289	37	b.	b.	PROPN
biomedich-205	289	38	,	,	PUNCT
biomedich-205	289	39	bingley	bingley	PROPN
biomedich-205	289	40	,	,	PUNCT
biomedich-205	289	41	m.	m.	NOUN
biomedich-205	289	42	,	,	PUNCT
biomedich-205	289	43	bonilla	bonilla	PROPN
biomedich-205	289	44	,	,	PUNCT
biomedich-205	289	45	c.	c.	PROPN
biomedich-205	289	46	,	,	PUNCT
biomedich-205	289	47	britto	britto	PROPN
biomedich-205	289	48	,	,	PUNCT
biomedich-205	289	49	r.	r.	PROPN
biomedich-205	289	50	,	,	PUNCT
biomedich-205	289	51	bursteinas	bursteinas	PROPN
biomedich-205	289	52	,	,	PUNCT
biomedich-205	289	53	b.	b.	PROPN
biomedich-205	289	54	,	,	PUNCT
biomedich-205	289	55	chavali	chavali	PROPN
biomedich-205	289	56	,	,	PUNCT
biomedich-205	289	57	g.	g.	PROPN
biomedich-205	289	58	,	,	PUNCT
biomedich-205	289	59	cibrian	cibrian	NOUN
biomedich-205	289	60	-	-	PUNCT
biomedich-205	289	61	uhalte	uhalte	NOUN
biomedich-205	289	62	,	,	PUNCT
biomedich-205	289	63	e.	e.	PROPN
biomedich-205	289	64	,	,	PUNCT
biomedich-205	289	65	da	da	PROPN
biomedich-205	289	66	silva	silva	PROPN
biomedich-205	289	67	,	,	PUNCT
biomedich-205	289	68	a.	a.	NOUN
biomedich-205	289	69	,	,	PUNCT
biomedich-205	289	70	de	de	PROPN
biomedich-205	289	71	giorgi	giorgi	NOUN
biomedich-205	289	72	,	,	PUNCT
biomedich-205	289	73	m.	m.	NOUN
biomedich-205	289	74	,	,	PUNCT
biomedich-205	289	75	dogan	dogan	PROPN
biomedich-205	289	76	,	,	PUNCT
biomedich-205	289	77	t.	t.	PROPN
biomedich-205	289	78	,	,	PUNCT
biomedich-205	289	79	fazzini	fazzini	PROPN
biomedich-205	289	80	,	,	PUNCT
biomedich-205	289	81	f.	f.	PROPN
biomedich-205	289	82	,	,	PUNCT
biomedich-205	289	83	…	…	PUNCT
biomedich-205	289	84	zhang	zhang	PROPN
biomedich-205	289	85	,	,	PUNCT
biomedich-205	289	86	j.	j.	PROPN
biomedich-205	289	87	(	(	PUNCT
biomedich-205	289	88	2015	2015	NUM
biomedich-205	289	89	)	)	PUNCT
biomedich-205	289	90	.	.	PUNCT
biomedich-205	290	1	uniprot	uniprot	ADJ
biomedich-205	290	2	:	:	PUNCT
biomedich-205	290	3	a	a	DET
biomedich-205	290	4	hub	hub	NOUN
biomedich-205	290	5	for	for	ADP
biomedich-205	290	6	protein	protein	NOUN
biomedich-205	290	7	information	information	NOUN
biomedich-205	290	8	.	.	PUNCT
biomedich-205	291	1	nucleic	nucleic	ADJ
biomedich-205	291	2	acids	acid	NOUN
biomedich-205	291	3	research	research	NOUN
biomedich-205	291	4	,	,	PUNCT
biomedich-205	291	5	43(d1	43(d1	NUM
biomedich-205	291	6	)	)	PUNCT
biomedich-205	291	7	,	,	PUNCT
biomedich-205	291	8	d204	d204	PROPN
biomedich-205	291	9	–	–	PUNCT
biomedich-205	291	10	d212	d212	PROPN
biomedich-205	291	11	.	.	PUNCT
biomedich-205	292	1	https://doi.org/10.1093/nar/gku989	https://doi.org/10.1093/nar/gku989	PROPN
biomedich-205	292	2	bawazeer	bawazeer	NOUN
biomedich-205	292	3	,	,	PUNCT
biomedich-205	292	4	n.	n.	PROPN
biomedich-205	292	5	a.	a.	PROPN
biomedich-205	292	6	,	,	PUNCT
biomedich-205	292	7	choudhry	choudhry	PROPN
biomedich-205	292	8	,	,	PUNCT
biomedich-205	292	9	h.	h.	PROPN
biomedich-205	292	10	,	,	PUNCT
biomedich-205	292	11	zamzami	zamzami	PROPN
biomedich-205	292	12	,	,	PUNCT
biomedich-205	292	13	m.	m.	NOUN
biomedich-205	292	14	a.	a.	PROPN
biomedich-205	292	15	,	,	PUNCT
biomedich-205	292	16	abdulaal	abdulaal	PROPN
biomedich-205	292	17	,	,	PUNCT
biomedich-205	292	18	w.	w.	PROPN
biomedich-205	292	19	h.	h.	PROPN
biomedich-205	292	20	,	,	PUNCT
biomedich-205	292	21	middleton	middleton	PROPN
biomedich-205	292	22	,	,	PUNCT
biomedich-205	292	23	b.	b.	PROPN
biomedich-205	292	24	,	,	PUNCT
biomedich-205	292	25	&	&	CCONJ
biomedich-205	292	26	moselhy	moselhy	PROPN
biomedich-205	292	27	,	,	PUNCT
biomedich-205	292	28	s.	s.	PROPN
biomedich-205	292	29	s.	s.	PROPN
biomedich-205	292	30	(	(	PUNCT
biomedich-205	292	31	2016	2016	NUM
biomedich-205	292	32	)	)	PUNCT
biomedich-205	292	33	.	.	PUNCT
biomedich-205	293	1	role	role	NOUN
biomedich-205	293	2	of	of	ADP
biomedich-205	293	3	hesperetin	hesperetin	NOUN
biomedich-205	293	4	in	in	ADP
biomedich-205	293	5	ldl	ldl	NOUN
biomedich-205	293	6	-	-	PUNCT
biomedich-205	293	7	receptor	receptor	NOUN
biomedich-205	293	8	expression	expression	NOUN
biomedich-205	293	9	in	in	ADP
biomedich-205	293	10	hepatoma	hepatoma	NOUN
biomedich-205	293	11	hepg2	hepg2	PUNCT
biomedich-205	293	12	cells	cell	NOUN
biomedich-205	293	13	.	.	PUNCT
biomedich-205	294	1	bmc	bmc	ADJ
biomedich-205	294	2	complementary	complementary	ADJ
biomedich-205	294	3	and	and	CCONJ
biomedich-205	294	4	alternative	alternative	ADJ
biomedich-205	294	5	medicine	medicine	NOUN
biomedich-205	294	6	,	,	PUNCT
biomedich-205	294	7	16(1	16(1	NUM
biomedich-205	294	8	)	)	PUNCT
biomedich-205	294	9	,	,	PUNCT
biomedich-205	294	10	1–7	1–7	X
biomedich-205	294	11	.	.	PUNCT
biomedich-205	294	12	https://doi.org/10.1186/s12906-016-1165-2	https://doi.org/10.1186/s12906-016-1165-2	PROPN
biomedich-205	294	13	burley	burley	PROPN
biomedich-205	294	14	,	,	PUNCT
biomedich-205	294	15	s.	s.	PROPN
biomedich-205	294	16	k.	k.	PROPN
biomedich-205	294	17	,	,	PUNCT
biomedich-205	294	18	bhikadiya	bhikadiya	PROPN
biomedich-205	294	19	,	,	PUNCT
biomedich-205	294	20	c.	c.	PROPN
biomedich-205	294	21	,	,	PUNCT
biomedich-205	294	22	bi	bi	PROPN
biomedich-205	294	23	,	,	PUNCT
biomedich-205	294	24	c.	c.	PROPN
biomedich-205	294	25	,	,	PUNCT
biomedich-205	294	26	bittrich	bittrich	PROPN
biomedich-205	294	27	,	,	PUNCT
biomedich-205	294	28	s.	s.	PROPN
biomedich-205	294	29	,	,	PUNCT
biomedich-205	294	30	chen	chen	PROPN
biomedich-205	294	31	,	,	PUNCT
biomedich-205	294	32	l.	l.	PROPN
biomedich-205	294	33	,	,	PUNCT
biomedich-205	294	34	crichlow	crichlow	NOUN
biomedich-205	294	35	,	,	PUNCT
biomedich-205	294	36	g.	g.	PROPN
biomedich-205	294	37	v.	v.	PROPN
biomedich-205	294	38	,	,	PUNCT
biomedich-205	294	39	christie	christie	PROPN
biomedich-205	294	40	,	,	PUNCT
biomedich-205	294	41	c.	c.	PROPN
biomedich-205	294	42	h.	h.	PROPN
biomedich-205	294	43	,	,	PUNCT
biomedich-205	294	44	dalenberg	dalenberg	PROPN
biomedich-205	294	45	,	,	PUNCT
biomedich-205	294	46	k.	k.	PROPN
biomedich-205	294	47	,	,	PUNCT
biomedich-205	294	48	di	di	PROPN
biomedich-205	294	49	costanzo	costanzo	PROPN
biomedich-205	294	50	,	,	PUNCT
biomedich-205	294	51	l.	l.	PROPN
biomedich-205	294	52	,	,	PUNCT
biomedich-205	294	53	duarte	duarte	PROPN
biomedich-205	294	54	,	,	PUNCT
biomedich-205	294	55	j.	j.	PROPN
biomedich-205	294	56	m.	m.	PROPN
biomedich-205	294	57	,	,	PUNCT
biomedich-205	294	58	dutta	dutta	PROPN
biomedich-205	294	59	,	,	PUNCT
biomedich-205	294	60	s.	s.	PROPN
biomedich-205	294	61	,	,	PUNCT
biomedich-205	294	62	feng	feng	PROPN
biomedich-205	294	63	,	,	PUNCT
biomedich-205	294	64	z.	z.	PROPN
biomedich-205	294	65	,	,	PUNCT
biomedich-205	294	66	ganesan	ganesan	PROPN
biomedich-205	294	67	,	,	PUNCT
biomedich-205	294	68	s.	s.	PROPN
biomedich-205	294	69	,	,	PUNCT
biomedich-205	294	70	goodsell	goodsell	PROPN
biomedich-205	294	71	,	,	PUNCT
biomedich-205	294	72	d.	d.	PROPN
biomedich-205	294	73	s.	s.	PROPN
biomedich-205	294	74	,	,	PUNCT
biomedich-205	294	75	ghosh	ghosh	PROPN
biomedich-205	294	76	,	,	PUNCT
biomedich-205	294	77	s.	s.	PROPN
biomedich-205	294	78	,	,	PUNCT
biomedich-205	294	79	green	green	PROPN
biomedich-205	294	80	,	,	PUNCT
biomedich-205	294	81	r.	r.	PROPN
biomedich-205	294	82	k.	k.	PROPN
biomedich-205	294	83	,	,	PUNCT
biomedich-205	294	84	guranovic	guranovic	PROPN
biomedich-205	294	85	,	,	PUNCT
biomedich-205	294	86	v.	v.	PROPN
biomedich-205	294	87	,	,	PUNCT
biomedich-205	294	88	guzenko	guzenko	PROPN
biomedich-205	294	89	,	,	PUNCT
biomedich-205	294	90	d.	d.	PROPN
biomedich-205	294	91	,	,	PUNCT
biomedich-205	294	92	hudson	hudson	PROPN
biomedich-205	294	93	,	,	PUNCT
biomedich-205	294	94	b.	b.	PROPN
biomedich-205	294	95	p.	p.	PROPN
biomedich-205	294	96	,	,	PUNCT
biomedich-205	294	97	…	…	PUNCT
biomedich-205	294	98	zhuravleva	zhuravleva	NOUN
biomedich-205	294	99	,	,	PUNCT
biomedich-205	294	100	m.	m.	NOUN
biomedich-205	294	101	(	(	PUNCT
biomedich-205	294	102	2021	2021	NUM
biomedich-205	294	103	)	)	PUNCT
biomedich-205	294	104	.	.	PUNCT
biomedich-205	295	1	rcsb	rcsb	PROPN
biomedich-205	295	2	protein	protein	NOUN
biomedich-205	295	3	data	datum	NOUN
biomedich-205	295	4	bank	bank	NOUN
biomedich-205	295	5	:	:	PUNCT
biomedich-205	295	6	powerful	powerful	ADJ
biomedich-205	295	7	new	new	ADJ
biomedich-205	295	8	tools	tool	NOUN
biomedich-205	295	9	for	for	ADP
biomedich-205	295	10	exploring	explore	VERB
biomedich-205	295	11	3d	3d	NUM
biomedich-205	295	12	structures	structure	NOUN
biomedich-205	295	13	of	of	ADP
biomedich-205	295	14	biological	biological	ADJ
biomedich-205	295	15	macromolecules	macromolecule	NOUN
biomedich-205	295	16	for	for	ADP
biomedich-205	295	17	basic	basic	ADJ
biomedich-205	295	18	and	and	CCONJ
biomedich-205	295	19	applied	applied	ADJ
biomedich-205	295	20	research	research	NOUN
biomedich-205	295	21	and	and	CCONJ
biomedich-205	295	22	education	education	NOUN
biomedich-205	295	23	in	in	ADP
biomedich-205	295	24	fundamental	fundamental	ADJ
biomedich-205	295	25	biology	biology	NOUN
biomedich-205	295	26	,	,	PUNCT
biomedich-205	295	27	biomedicine	biomedicine	NOUN
biomedich-205	295	28	,	,	PUNCT
biomedich-205	295	29	biotechnology	biotechnology	NOUN
biomedich-205	295	30	,	,	PUNCT
biomedich-205	295	31	bioengineering	bioengineering	NOUN
biomedich-205	295	32	and	and	CCONJ
biomedich-205	295	33	energy	energy	NOUN
biomedich-205	295	34	sciences	science	NOUN
biomedich-205	295	35	.	.	PUNCT
biomedich-205	296	1	nucleic	nucleic	ADJ
biomedich-205	296	2	acids	acid	NOUN
biomedich-205	296	3	research	research	NOUN
biomedich-205	296	4	,	,	PUNCT
biomedich-205	296	5	49(1	49(1	NOUN
biomedich-205	296	6	)	)	PUNCT
biomedich-205	296	7	,	,	PUNCT
biomedich-205	296	8	d437	d437	PROPN
biomedich-205	296	9	–	–	PUNCT
biomedich-205	296	10	d451	d451	PROPN
biomedich-205	296	11	.	.	PUNCT
biomedich-205	297	1	https://doi.org/10.1093/nar/gkaa1038	https://doi.org/10.1093/nar/gkaa1038	PROPN
biomedich-205	297	2	chaudhary	chaudhary	PROPN
biomedich-205	297	3	,	,	PUNCT
biomedich-205	297	4	r.	r.	PROPN
biomedich-205	297	5	,	,	PUNCT
biomedich-205	297	6	garg	garg	PROPN
biomedich-205	297	7	,	,	PUNCT
biomedich-205	297	8	j.	j.	PROPN
biomedich-205	297	9	,	,	PUNCT
biomedich-205	297	10	shah	shah	PROPN
biomedich-205	297	11	,	,	PUNCT
biomedich-205	297	12	n.	n.	NOUN
biomedich-205	297	13	,	,	PUNCT
biomedich-205	297	14	&	&	CCONJ
biomedich-205	297	15	sumner	sumner	PROPN
biomedich-205	297	16	,	,	PUNCT
biomedich-205	297	17	a.	a.	NOUN
biomedich-205	297	18	(	(	PUNCT
biomedich-205	297	19	2017	2017	NUM
biomedich-205	297	20	)	)	PUNCT
biomedich-205	297	21	.	.	PUNCT
biomedich-205	298	1	pcsk9	pcsk9	PROPN
biomedich-205	298	2	inhibitors	inhibitor	NOUN
biomedich-205	298	3	:	:	PUNCT
biomedich-205	298	4	a	a	DET
biomedich-205	298	5	new	new	ADJ
biomedich-205	298	6	era	era	NOUN
biomedich-205	298	7	of	of	ADP
biomedich-205	298	8	lipid	lipid	NOUN
biomedich-205	298	9	lowering	lower	VERB
biomedich-205	298	10	therapy	therapy	NOUN
biomedich-205	298	11	.	.	PUNCT
biomedich-205	299	1	world	world	PROPN
biomedich-205	299	2	journal	journal	PROPN
biomedich-205	299	3	of	of	ADP
biomedich-205	299	4	cardiology	cardiology	NOUN
biomedich-205	299	5	,	,	PUNCT
biomedich-205	299	6	9(2	9(2	NUM
biomedich-205	299	7	)	)	PUNCT
biomedich-205	299	8	,	,	PUNCT
biomedich-205	299	9	76	76	NUM
biomedich-205	299	10	.	.	PUNCT
biomedich-205	300	1	https://doi.org/10.4330/wjc.v9.i2.76	https://doi.org/10.4330/wjc.v9.i2.76	PROPN
biomedich-205	300	2	chu	chu	PROPN
biomedich-205	300	3	,	,	PUNCT
biomedich-205	300	4	k.	k.	PROPN
biomedich-205	300	5	a.	a.	PROPN
biomedich-205	300	6	,	,	PUNCT
biomedich-205	300	7	&	&	CCONJ
biomedich-205	300	8	yalkowsky	yalkowsky	PROPN
biomedich-205	300	9	,	,	PUNCT
biomedich-205	300	10	s.	s.	PROPN
biomedich-205	300	11	h.	h.	PROPN
biomedich-205	300	12	(	(	PUNCT
biomedich-205	300	13	2009	2009	NUM
biomedich-205	300	14	)	)	PUNCT
biomedich-205	300	15	.	.	PUNCT
biomedich-205	301	1	an	an	DET
biomedich-205	301	2	interesting	interesting	ADJ
biomedich-205	301	3	relationship	relationship	NOUN
biomedich-205	301	4	between	between	ADP
biomedich-205	301	5	drug	drug	NOUN
biomedich-205	301	6	absorption	absorption	NOUN
biomedich-205	301	7	and	and	CCONJ
biomedich-205	301	8	melting	melting	NOUN
biomedich-205	301	9	point	point	NOUN
biomedich-205	301	10	.	.	PUNCT
biomedich-205	302	1	international	international	ADJ
biomedich-205	302	2	journal	journal	PROPN
biomedich-205	302	3	of	of	ADP
biomedich-205	302	4	pharmaceutics	pharmaceutic	NOUN
biomedich-205	302	5	,	,	PUNCT
biomedich-205	302	6	373(1–2	373(1–2	NUM
biomedich-205	302	7	)	)	PUNCT
biomedich-205	302	8	,	,	PUNCT
biomedich-205	302	9	24–40	24–40	NUM
biomedich-205	302	10	.	.	PUNCT
biomedich-205	303	1	https://doi.org/10.1016/j.ijpharm.2009.01.026	https://doi.org/10.1016/j.ijpharm.2009.01.026	PROPN
biomedich-205	303	2	daina	daina	PROPN
biomedich-205	303	3	,	,	PUNCT
biomedich-205	303	4	a.	a.	PROPN
biomedich-205	303	5	,	,	PUNCT
biomedich-205	303	6	michielin	michielin	PROPN
biomedich-205	303	7	,	,	PUNCT
biomedich-205	303	8	o.	o.	PROPN
biomedich-205	303	9	,	,	PUNCT
biomedich-205	303	10	&	&	CCONJ
biomedich-205	303	11	zoete	zoete	PROPN
biomedich-205	303	12	,	,	PUNCT
biomedich-205	303	13	v.	v.	PROPN
biomedich-205	303	14	(	(	PUNCT
biomedich-205	303	15	2017	2017	NUM
biomedich-205	303	16	)	)	PUNCT
biomedich-205	303	17	.	.	PUNCT
biomedich-205	304	1	swissadme	swissadme	NOUN
biomedich-205	304	2	:	:	PUNCT
biomedich-205	304	3	a	a	DET
biomedich-205	304	4	free	free	ADJ
biomedich-205	304	5	web	web	NOUN
biomedich-205	304	6	tool	tool	NOUN
biomedich-205	304	7	to	to	PART
biomedich-205	304	8	evaluate	evaluate	VERB
biomedich-205	304	9	pharmacokinetics	pharmacokinetic	NOUN
biomedich-205	304	10	,	,	PUNCT
biomedich-205	304	11	drug	drug	NOUN
biomedich-205	304	12	-	-	PUNCT
biomedich-205	304	13	likeness	likeness	NOUN
biomedich-205	304	14	and	and	CCONJ
biomedich-205	304	15	medicinal	medicinal	ADJ
biomedich-205	304	16	chemistry	chemistry	NOUN
biomedich-205	304	17	friendliness	friendliness	NOUN
biomedich-205	304	18	of	of	ADP
biomedich-205	304	19	small	small	ADJ
biomedich-205	304	20	molecules	molecule	NOUN
biomedich-205	304	21	.	.	PUNCT
biomedich-205	305	1	scientific	scientific	ADJ
biomedich-205	305	2	reports	report	NOUN
biomedich-205	305	3	,	,	PUNCT
biomedich-205	305	4	7(january	7(january	NUM
biomedich-205	305	5	)	)	PUNCT
biomedich-205	305	6	,	,	PUNCT
biomedich-205	305	7	1–13	1–13	NOUN
biomedich-205	305	8	.	.	PUNCT
biomedich-205	306	1	https://doi.org/10.1038/srep42717	https://doi.org/10.1038/srep42717	PROPN
biomedich-205	306	2	ding	ding	PROPN
biomedich-205	306	3	,	,	PUNCT
biomedich-205	306	4	z.	z.	PROPN
biomedich-205	306	5	,	,	PUNCT
biomedich-205	306	6	liu	liu	PROPN
biomedich-205	306	7	,	,	PUNCT
biomedich-205	306	8	s.	s.	PROPN
biomedich-205	306	9	,	,	PUNCT
biomedich-205	306	10	wang	wang	PROPN
biomedich-205	306	11	,	,	PUNCT
biomedich-205	306	12	x.	x.	PROPN
biomedich-205	306	13	,	,	PUNCT
biomedich-205	306	14	deng	deng	PROPN
biomedich-205	306	15	,	,	PUNCT
biomedich-205	306	16	x.	x.	PROPN
biomedich-205	306	17	,	,	PUNCT
biomedich-205	306	18	fan	fan	PROPN
biomedich-205	306	19	,	,	PUNCT
biomedich-205	306	20	y.	y.	PROPN
biomedich-205	306	21	,	,	PUNCT
biomedich-205	306	22	sun	sun	PROPN
biomedich-205	306	23	,	,	PUNCT
biomedich-205	306	24	c.	c.	PROPN
biomedich-205	306	25	,	,	PUNCT
biomedich-205	306	26	wang	wang	PROPN
biomedich-205	306	27	,	,	PUNCT
biomedich-205	306	28	y.	y.	PROPN
biomedich-205	306	29	,	,	PUNCT
biomedich-205	306	30	&	&	CCONJ
biomedich-205	306	31	mehta	mehta	PROPN
biomedich-205	306	32	,	,	PUNCT
biomedich-205	306	33	j.	j.	PROPN
biomedich-205	306	34	l.	l.	PROPN
biomedich-205	306	35	(	(	PUNCT
biomedich-205	306	36	2015	2015	NUM
biomedich-205	306	37	)	)	PUNCT
biomedich-205	306	38	.	.	PUNCT
biomedich-205	307	1	hemodynamic	hemodynamic	ADJ
biomedich-205	307	2	shear	shear	NOUN
biomedich-205	307	3	stress	stress	NOUN
biomedich-205	307	4	via	via	ADP
biomedich-205	307	5	ros	ros	PROPN
biomedich-205	307	6	modulates	modulate	NOUN
biomedich-205	307	7	pcsk9	pcsk9	NOUN
biomedich-205	307	8	expression	expression	NOUN
biomedich-205	307	9	in	in	ADP
biomedich-205	307	10	human	human	ADJ
biomedich-205	307	11	vascular	vascular	ADJ
biomedich-205	307	12	endothelial	endothelial	NOUN
biomedich-205	307	13	and	and	CCONJ
biomedich-205	307	14	smooth	smooth	ADJ
biomedich-205	307	15	muscle	muscle	NOUN
biomedich-205	307	16	cells	cell	NOUN
biomedich-205	307	17	and	and	CCONJ
biomedich-205	307	18	along	along	ADP
biomedich-205	307	19	the	the	DET
biomedich-205	307	20	mouse	mouse	NOUN
biomedich-205	307	21	aorta	aorta	NOUN
biomedich-205	307	22	.	.	PUNCT
biomedich-205	308	1	antioxidants	antioxidant	NOUN
biomedich-205	308	2	and	and	CCONJ
biomedich-205	308	3	redox	redox	NOUN
biomedich-205	308	4	signaling	signaling	NOUN
biomedich-205	308	5	,	,	PUNCT
biomedich-205	308	6	22(9	22(9	NUM
biomedich-205	308	7	)	)	PUNCT
biomedich-205	308	8	,	,	PUNCT
biomedich-205	308	9	760–771	760–771	NUM
biomedich-205	308	10	.	.	PUNCT
biomedich-205	309	1	https://doi.org/10.1089/ars.2014.6054	https://doi.org/10.1089/ars.2014.6054	PROPN
biomedich-205	309	2	du	du	PROPN
biomedich-205	309	3	,	,	PUNCT
biomedich-205	309	4	f.	f.	PROPN
biomedich-205	309	5	,	,	PUNCT
biomedich-205	309	6	hui	hui	PROPN
biomedich-205	309	7	,	,	PUNCT
biomedich-205	309	8	y.	y.	PROPN
biomedich-205	309	9	,	,	PUNCT
biomedich-205	309	10	zhang	zhang	PROPN
biomedich-205	309	11	,	,	PUNCT
biomedich-205	309	12	m.	m.	NOUN
biomedich-205	309	13	,	,	PUNCT
biomedich-205	309	14	linton	linton	PROPN
biomedich-205	309	15	,	,	PUNCT
biomedich-205	309	16	m.	m.	PROPN
biomedich-205	309	17	f.	f.	PROPN
biomedich-205	309	18	,	,	PUNCT
biomedich-205	309	19	fazio	fazio	PROPN
biomedich-205	309	20	,	,	PUNCT
biomedich-205	309	21	s.	s.	PROPN
biomedich-205	309	22	,	,	PUNCT
biomedich-205	309	23	&	&	CCONJ
biomedich-205	309	24	fan	fan	PROPN
biomedich-205	309	25	,	,	PUNCT
biomedich-205	309	26	d.	d.	PROPN
biomedich-205	309	27	(	(	PUNCT
biomedich-205	309	28	2011	2011	NUM
biomedich-205	309	29	)	)	PUNCT
biomedich-205	309	30	.	.	PUNCT
biomedich-205	310	1	novel	novel	ADJ
biomedich-205	310	2	domain	domain	NOUN
biomedich-205	310	3	interaction	interaction	NOUN
biomedich-205	310	4	regulates	regulate	VERB
biomedich-205	310	5	secretion	secretion	NOUN
biomedich-205	310	6	of	of	ADP
biomedich-205	310	7	proprotein	proprotein	PROPN
biomedich-205	310	8	convertase	convertase	PROPN
biomedich-205	310	9	subtilisin	subtilisin	PROPN
biomedich-205	310	10	/	/	SYM
biomedich-205	310	11	kexin	kexin	NOUN
biomedich-205	310	12	type	type	NOUN
biomedich-205	310	13	9	9	NUM
biomedich-205	310	14	(	(	PUNCT
biomedich-205	310	15	pcsk9	pcsk9	NOUN
biomedich-205	310	16	)	)	PUNCT
biomedich-205	310	17	protein	protein	NOUN
biomedich-205	310	18	.	.	PUNCT
biomedich-205	311	1	journal	journal	NOUN
biomedich-205	311	2	of	of	ADP
biomedich-205	311	3	biological	biological	ADJ
biomedich-205	311	4	chemistry	chemistry	NOUN
biomedich-205	311	5	,	,	PUNCT
biomedich-205	311	6	286(50	286(50	NUM
biomedich-205	311	7	)	)	PUNCT
biomedich-205	311	8	,	,	PUNCT
biomedich-205	311	9	43054	43054	NUM
biomedich-205	311	10	–	–	PUNCT
biomedich-205	311	11	43061	43061	NUM
biomedich-205	311	12	.	.	PUNCT
biomedich-205	312	1	https://doi.org/10.1074/jbc.m111.273474	https://doi.org/10.1074/jbc.m111.273474	PROPN
biomedich-205	312	2	ferrari	ferrari	PROPN
biomedich-205	312	3	,	,	PUNCT
biomedich-205	312	4	r.	r.	PROPN
biomedich-205	312	5	,	,	PUNCT
biomedich-205	312	6	guardigli	guardigli	PROPN
biomedich-205	312	7	,	,	PUNCT
biomedich-205	312	8	g.	g.	PROPN
biomedich-205	312	9	,	,	PUNCT
biomedich-205	312	10	&	&	CCONJ
biomedich-205	312	11	ceconi	ceconi	PROPN
biomedich-205	312	12	,	,	PUNCT
biomedich-205	312	13	c.	c.	PROPN
biomedich-205	312	14	(	(	PUNCT
biomedich-205	312	15	2010	2010	NUM
biomedich-205	312	16	)	)	PUNCT
biomedich-205	312	17	.	.	PUNCT
biomedich-205	313	1	secondary	secondary	ADJ
biomedich-205	313	2	prevention	prevention	NOUN
biomedich-205	313	3	of	of	ADP
biomedich-205	313	4	cad	cad	PROPN
biomedich-205	313	5	with	with	ADP
biomedich-205	313	6	ace	ace	NOUN
biomedich-205	313	7	inhibitors	inhibitor	NOUN
biomedich-205	313	8	:	:	PUNCT
biomedich-205	313	9	a	a	DET
biomedich-205	313	10	struggle	struggle	NOUN
biomedich-205	313	11	between	between	ADP
biomedich-205	313	12	life	life	NOUN
biomedich-205	313	13	and	and	CCONJ
biomedich-205	313	14	death	death	NOUN
biomedich-205	313	15	of	of	ADP
biomedich-205	313	16	the	the	DET
biomedich-205	313	17	endothelium	endothelium	NOUN
biomedich-205	313	18	.	.	PUNCT
biomedich-205	314	1	cardiovascular	cardiovascular	ADJ
biomedich-205	314	2	drugs	drug	NOUN
biomedich-205	314	3	and	and	CCONJ
biomedich-205	314	4	therapy	therapy	NOUN
biomedich-205	314	5	,	,	PUNCT
biomedich-205	314	6	24(4	24(4	NUM
biomedich-205	314	7	)	)	PUNCT
biomedich-205	314	8	,	,	PUNCT
biomedich-205	314	9	331–339	331–339	NUM
biomedich-205	314	10	.	.	PUNCT
biomedich-205	315	1	https://doi.org/10.1007/s10557-0106244-x	https://doi.org/10.1007/s10557-0106244-x	PROPN
biomedich-205	315	2	guidi	guidi	PROPN
biomedich-205	315	3	,	,	PUNCT
biomedich-205	315	4	i.	i.	PROPN
biomedich-205	315	5	,	,	PUNCT
biomedich-205	315	6	galimberti	galimberti	PROPN
biomedich-205	315	7	,	,	PUNCT
biomedich-205	315	8	d.	d.	PROPN
biomedich-205	315	9	,	,	PUNCT
biomedich-205	315	10	lonati	lonati	PROPN
biomedich-205	315	11	,	,	PUNCT
biomedich-205	315	12	s.	s.	PROPN
biomedich-205	315	13	,	,	PUNCT
biomedich-205	315	14	novembrino	novembrino	PROPN
biomedich-205	315	15	,	,	PUNCT
biomedich-205	315	16	c.	c.	PROPN
biomedich-205	315	17	,	,	PUNCT
biomedich-205	315	18	bamonti	bamonti	PROPN
biomedich-205	315	19	,	,	PUNCT
biomedich-205	315	20	f.	f.	PROPN
biomedich-205	315	21	,	,	PUNCT
biomedich-205	315	22	tiriticco	tiriticco	PROPN
biomedich-205	315	23	,	,	PUNCT
biomedich-205	315	24	m.	m.	NOUN
biomedich-205	315	25	,	,	PUNCT
biomedich-205	315	26	fenoglio	fenoglio	ADJ
biomedich-205	315	27	,	,	PUNCT
biomedich-205	315	28	c.	c.	PROPN
biomedich-205	315	29	,	,	PUNCT
biomedich-205	315	30	venturelli	venturelli	PROPN
biomedich-205	315	31	,	,	PUNCT
biomedich-205	315	32	e.	e.	PROPN
biomedich-205	315	33	,	,	PUNCT
biomedich-205	315	34	baron	baron	NOUN
biomedich-205	315	35	,	,	PUNCT
biomedich-205	315	36	p.	p.	PROPN
biomedich-205	315	37	,	,	PUNCT
biomedich-205	315	38	bresolin	bresolin	NOUN
biomedich-205	315	39	,	,	PUNCT
biomedich-205	315	40	n.	n.	NOUN
biomedich-205	315	41	,	,	PUNCT
biomedich-205	315	42	&	&	CCONJ
biomedich-205	315	43	scarpini	scarpini	PROPN
biomedich-205	315	44	,	,	PUNCT
biomedich-205	315	45	e.	e.	PROPN
biomedich-205	315	46	(	(	PUNCT
biomedich-205	315	47	2006	2006	NUM
biomedich-205	315	48	)	)	PUNCT
biomedich-205	315	49	.	.	PUNCT
biomedich-205	316	1	oxidative	oxidative	ADJ
biomedich-205	316	2	imbalance	imbalance	NOUN
biomedich-205	316	3	in	in	ADP
biomedich-205	316	4	patients	patient	NOUN
biomedich-205	316	5	with	with	ADP
biomedich-205	316	6	mild	mild	ADJ
biomedich-205	316	7	cognitive	cognitive	ADJ
biomedich-205	316	8	impairment	impairment	NOUN
biomedich-205	316	9	and	and	CCONJ
biomedich-205	316	10	alzheimer	alzheimer	NOUN
biomedich-205	316	11	’s	’s	PART
biomedich-205	316	12	disease	disease	NOUN
biomedich-205	316	13	.	.	PUNCT
biomedich-205	317	1	neurobiology	neurobiology	NOUN
biomedich-205	317	2	of	of	ADP
biomedich-205	317	3	aging	aging	NOUN
biomedich-205	317	4	,	,	PUNCT
biomedich-205	317	5	27(2	27(2	NUM
biomedich-205	317	6	)	)	PUNCT
biomedich-205	317	7	,	,	PUNCT
biomedich-205	317	8	262–269	262–269	NUM
biomedich-205	317	9	.	.	PUNCT
biomedich-205	318	1	https://doi.org/10.1016/j.neurobiolaging.2005.01.001	https://doi.org/10.1016/j.neurobiolaging.2005.01.001	PROPN
biomedich-205	318	2	hanwell	hanwell	PROPN
biomedich-205	318	3	,	,	PUNCT
biomedich-205	318	4	m.	m.	PROPN
biomedich-205	318	5	d.	d.	PROPN
biomedich-205	318	6	,	,	PUNCT
biomedich-205	318	7	curtis	curtis	PROPN
biomedich-205	318	8	,	,	PUNCT
biomedich-205	318	9	d.	d.	PROPN
biomedich-205	318	10	e.	e.	PROPN
biomedich-205	318	11	,	,	PUNCT
biomedich-205	318	12	lonie	lonie	PROPN
biomedich-205	318	13	,	,	PUNCT
biomedich-205	318	14	d.	d.	PROPN
biomedich-205	318	15	c.	c.	PROPN
biomedich-205	318	16	,	,	PUNCT
biomedich-205	318	17	vandermeerschd	vandermeerschd	NOUN
biomedich-205	318	18	,	,	PUNCT
biomedich-205	318	19	t.	t.	PROPN
biomedich-205	318	20	,	,	PUNCT
biomedich-205	318	21	zurek	zurek	PROPN
biomedich-205	318	22	,	,	PUNCT
biomedich-205	318	23	e.	e.	PROPN
biomedich-205	318	24	,	,	PUNCT
biomedich-205	318	25	&	&	CCONJ
biomedich-205	318	26	hutchison	hutchison	PROPN
biomedich-205	318	27	,	,	PUNCT
biomedich-205	318	28	g.	g.	PROPN
biomedich-205	318	29	r.	r.	PROPN
biomedich-205	318	30	(	(	PUNCT
biomedich-205	318	31	2012	2012	NUM
biomedich-205	318	32	)	)	PUNCT
biomedich-205	318	33	.	.	PUNCT
biomedich-205	319	1	avogadro	avogadro	PROPN
biomedich-205	319	2	:	:	PUNCT
biomedich-205	319	3	an	an	DET
biomedich-205	319	4	advanced	advanced	ADJ
biomedich-205	319	5	semantic	semantic	ADJ
biomedich-205	319	6	chemical	chemical	NOUN
biomedich-205	319	7	editor	editor	NOUN
biomedich-205	319	8	,	,	PUNCT
biomedich-205	319	9	visualization	visualization	NOUN
biomedich-205	319	10	,	,	PUNCT
biomedich-205	319	11	and	and	CCONJ
biomedich-205	319	12	analysis	analysis	NOUN
biomedich-205	319	13	platform	platform	NOUN
biomedich-205	319	14	.	.	PUNCT
biomedich-205	320	1	journal	journal	PROPN
biomedich-205	320	2	of	of	ADP
biomedich-205	320	3	cheminformatics	cheminformatic	NOUN
biomedich-205	320	4	,	,	PUNCT
biomedich-205	320	5	4(8	4(8	NUM
biomedich-205	320	6	)	)	PUNCT
biomedich-205	320	7	.	.	PUNCT
biomedich-205	321	1	https://doi.org/10.1186/1758-2946-4-17	https://doi.org/10.1186/1758-2946-4-17	PROPN
biomedich-205	321	2	horton	horton	PROPN
biomedich-205	321	3	,	,	PUNCT
biomedich-205	321	4	j.	j.	PROPN
biomedich-205	321	5	d.	d.	PROPN
biomedich-205	321	6	,	,	PUNCT
biomedich-205	321	7	cohen	cohen	PROPN
biomedich-205	321	8	,	,	PUNCT
biomedich-205	321	9	j.	j.	PROPN
biomedich-205	321	10	c.	c.	PROPN
biomedich-205	321	11	,	,	PUNCT
biomedich-205	321	12	&	&	CCONJ
biomedich-205	321	13	hobbs	hobbs	PROPN
biomedich-205	321	14	,	,	PUNCT
biomedich-205	321	15	h.	h.	PROPN
biomedich-205	321	16	h.	h.	PROPN
biomedich-205	321	17	(	(	PUNCT
biomedich-205	321	18	2007	2007	NUM
biomedich-205	321	19	)	)	PUNCT
biomedich-205	321	20	.	.	PUNCT
biomedich-205	322	1	molecular	molecular	ADJ
biomedich-205	322	2	biology	biology	NOUN
biomedich-205	322	3	of	of	ADP
biomedich-205	322	4	pcsk9	pcsk9	PROPN
biomedich-205	322	5	:	:	PUNCT
biomedich-205	322	6	its	its	PRON
biomedich-205	322	7	role	role	NOUN
biomedich-205	322	8	in	in	ADP
biomedich-205	322	9	ldl	ldl	NOUN
biomedich-205	322	10	metabolism	metabolism	NOUN
biomedich-205	322	11	.	.	PUNCT
biomedich-205	323	1	trends	trend	NOUN
biomedich-205	323	2	in	in	ADP
biomedich-205	323	3	biochemical	biochemical	ADJ
biomedich-205	323	4	sciences	science	NOUN
biomedich-205	323	5	,	,	PUNCT
biomedich-205	323	6	32(2	32(2	NUM
biomedich-205	323	7	)	)	PUNCT
biomedich-205	323	8	,	,	PUNCT
biomedich-205	323	9	71–77	71–77	X
biomedich-205	323	10	.	.	PUNCT
biomedich-205	324	1	https://doi.org/10.1016/j.tibs.2006.12.008	https://doi.org/10.1016/j.tibs.2006.12.008	PROPN
biomedich-205	324	2	horton	horton	PROPN
biomedich-205	324	3	,	,	PUNCT
biomedich-205	324	4	j.	j.	PROPN
biomedich-205	324	5	d.	d.	PROPN
biomedich-205	324	6	,	,	PUNCT
biomedich-205	324	7	cohen	cohen	PROPN
biomedich-205	324	8	,	,	PUNCT
biomedich-205	324	9	j.	j.	PROPN
biomedich-205	324	10	c.	c.	PROPN
biomedich-205	324	11	,	,	PUNCT
biomedich-205	324	12	&	&	CCONJ
biomedich-205	324	13	hobbs	hobbs	PROPN
biomedich-205	324	14	,	,	PUNCT
biomedich-205	324	15	h.	h.	PROPN
biomedich-205	324	16	h.	h.	PROPN
biomedich-205	324	17	(	(	PUNCT
biomedich-205	324	18	2009	2009	NUM
biomedich-205	324	19	)	)	PUNCT
biomedich-205	324	20	.	.	PUNCT
biomedich-205	325	1	pcsk9	pcsk9	NOUN
biomedich-205	325	2	:	:	PUNCT
biomedich-205	325	3	a	a	DET
biomedich-205	325	4	convertase	convertase	NOUN
biomedich-205	325	5	that	that	PRON
biomedich-205	325	6	coordinates	coordinate	VERB
biomedich-205	325	7	ldl	ldl	NOUN
biomedich-205	325	8	catabolism	catabolism	NOUN
biomedich-205	325	9	.	.	PUNCT
biomedich-205	326	1	journal	journal	PROPN
biomedich-205	326	2	of	of	ADP
biomedich-205	326	3	lipid	lipid	PROPN
biomedich-205	326	4	research	research	NOUN
biomedich-205	326	5	,	,	PUNCT
biomedich-205	326	6	50(suppl	50(suppl	NUM
biomedich-205	326	7	.	.	PUNCT
biomedich-205	326	8	)	)	PUNCT
biomedich-205	326	9	.	.	PUNCT
biomedich-205	327	1	https://doi.org/10.1194/jlr.r800091jlr200	https://doi.org/10.1194/jlr.r800091jlr200	PROPN
biomedich-205	327	2	hyock	hyock	NOUN
biomedich-205	327	3	,	,	PUNCT
biomedich-205	327	4	j.	j.	PROPN
biomedich-205	327	5	k.	k.	PROPN
biomedich-205	327	6	,	,	PUNCT
biomedich-205	327	7	lagace	lagace	PROPN
biomedich-205	327	8	,	,	PUNCT
biomedich-205	327	9	t.	t.	PROPN
biomedich-205	327	10	a.	a.	PROPN
biomedich-205	327	11	,	,	PUNCT
biomedich-205	327	12	mcnutt	mcnutt	PROPN
biomedich-205	327	13	,	,	PUNCT
biomedich-205	327	14	m.	m.	PROPN
biomedich-205	327	15	c.	c.	PROPN
biomedich-205	327	16	,	,	PUNCT
biomedich-205	327	17	horton	horton	PROPN
biomedich-205	327	18	,	,	PUNCT
biomedich-205	327	19	j.	j.	PROPN
biomedich-205	327	20	d.	d.	PROPN
biomedich-205	327	21	,	,	PUNCT
biomedich-205	327	22	&	&	CCONJ
biomedich-205	327	23	deisenhofer	deisenhofer	NOUN
biomedich-205	327	24	,	,	PUNCT
biomedich-205	327	25	j.	j.	PROPN
biomedich-205	327	26	(	(	PUNCT
biomedich-205	327	27	2008	2008	NUM
biomedich-205	327	28	)	)	PUNCT
biomedich-205	327	29	.	.	PUNCT
biomedich-205	328	1	molecular	molecular	ADJ
biomedich-205	328	2	basis	basis	NOUN
biomedich-205	328	3	for	for	ADP
biomedich-205	328	4	ldl	ldl	NOUN
biomedich-205	328	5	receptor	receptor	NOUN
biomedich-205	328	6	recognition	recognition	NOUN
biomedich-205	328	7	by	by	ADP
biomedich-205	328	8	pcsk9	pcsk9	PROPN
biomedich-205	328	9	.	.	PUNCT
biomedich-205	329	1	proceedings	proceeding	NOUN
biomedich-205	329	2	of	of	ADP
biomedich-205	329	3	the	the	DET
biomedich-205	329	4	national	national	PROPN
biomedich-205	329	5	academy	academy	PROPN
biomedich-205	329	6	of	of	ADP
biomedich-205	329	7	sciences	sciences	PROPN
biomedich-205	329	8	of	of	ADP
biomedich-205	329	9	the	the	DET
biomedich-205	329	10	united	united	PROPN
biomedich-205	329	11	states	states	PROPN
biomedich-205	329	12	of	of	ADP
biomedich-205	329	13	america	america	PROPN
biomedich-205	329	14	,	,	PUNCT
biomedich-205	329	15	105(6	105(6	NUM
biomedich-205	329	16	)	)	PUNCT
biomedich-205	329	17	,	,	PUNCT
biomedich-205	329	18	1820	1820	NUM
biomedich-205	329	19	–	–	PUNCT
biomedich-205	329	20	1825	1825	NUM
biomedich-205	329	21	.	.	PUNCT
biomedich-205	330	1	https://doi.org/10.1073/pnas.0712064105	https://doi.org/10.1073/pnas.0712064105	PROPN
biomedich-205	330	2	jaghoori	jaghoori	PROPN
biomedich-205	330	3	,	,	PUNCT
biomedich-205	330	4	m.	m.	NOUN
biomedich-205	330	5	m.	m.	NOUN
biomedich-205	330	6	,	,	PUNCT
biomedich-205	330	7	bleijlevens	bleijlevens	PROPN
biomedich-205	330	8	,	,	PUNCT
biomedich-205	330	9	b.	b.	PROPN
biomedich-205	330	10	,	,	PUNCT
biomedich-205	330	11	&	&	CCONJ
biomedich-205	330	12	olabarriaga	olabarriaga	NOUN
biomedich-205	330	13	,	,	PUNCT
biomedich-205	330	14	s.	s.	PROPN
biomedich-205	330	15	d.	d.	PROPN
biomedich-205	330	16	(	(	PUNCT
biomedich-205	330	17	2016	2016	NUM
biomedich-205	330	18	)	)	PUNCT
biomedich-205	330	19	.	.	PUNCT
biomedich-205	331	1	1001	1001	NUM
biomedich-205	331	2	ways	way	NOUN
biomedich-205	331	3	to	to	PART
biomedich-205	331	4	run	run	VERB
biomedich-205	331	5	autodock	autodock	NOUN
biomedich-205	331	6	vina	vina	NOUN
biomedich-205	331	7	for	for	ADP
biomedich-205	331	8	virtual	virtual	ADJ
biomedich-205	331	9	screening	screening	NOUN
biomedich-205	331	10	.	.	PUNCT
biomedich-205	332	1	journal	journal	PROPN
biomedich-205	332	2	of	of	ADP
biomedich-205	332	3	computer	computer	NOUN
biomedich-205	332	4	-	-	PUNCT
biomedich-205	332	5	aided	aid	VERB
biomedich-205	332	6	molecular	molecular	ADJ
biomedich-205	332	7	design	design	NOUN
biomedich-205	332	8	,	,	PUNCT
biomedich-205	332	9	30(3	30(3	NUM
biomedich-205	332	10	)	)	PUNCT
biomedich-205	332	11	,	,	PUNCT
biomedich-205	332	12	237	237	NUM
biomedich-205	332	13	–	–	PUNCT
biomedich-205	332	14	249	249	NUM
biomedich-205	332	15	.	.	PUNCT
biomedich-205	333	1	https://doi.org/10.1007/s10822-016-9900-9	https://doi.org/10.1007/s10822-016-9900-9	PROPN
biomedich-205	333	2	joseph	joseph	PROPN
biomedich-205	333	3	,	,	PUNCT
biomedich-205	333	4	l.	l.	PROPN
biomedich-205	333	5	,	,	PUNCT
biomedich-205	333	6	&	&	CCONJ
biomedich-205	333	7	robinson	robinson	PROPN
biomedich-205	333	8	,	,	PUNCT
biomedich-205	333	9	j.	j.	PROPN
biomedich-205	333	10	g.	g.	PROPN
biomedich-205	333	11	(	(	PUNCT
biomedich-205	333	12	2015	2015	NUM
biomedich-205	333	13	)	)	PUNCT
biomedich-205	333	14	.	.	PUNCT
biomedich-205	334	1	proprotein	proprotein	PROPN
biomedich-205	334	2	convertase	convertase	PROPN
biomedich-205	334	3	subtilisin	subtilisin	PROPN
biomedich-205	334	4	/	/	SYM
biomedich-205	334	5	kexin	kexin	NOUN
biomedich-205	334	6	type	type	NOUN
biomedich-205	334	7	9	9	NUM
biomedich-205	334	8	(	(	PUNCT
biomedich-205	334	9	pcsk9	pcsk9	NOUN
biomedich-205	334	10	)	)	PUNCT
biomedich-205	334	11	inhibition	inhibition	NOUN
biomedich-205	334	12	and	and	CCONJ
biomedich-205	334	13	the	the	DET
biomedich-205	334	14	future	future	NOUN
biomedich-205	334	15	of	of	ADP
biomedich-205	334	16	lipid	lipid	NOUN
biomedich-205	334	17	lowering	lower	VERB
biomedich-205	334	18	therapy	therapy	NOUN
biomedich-205	334	19	.	.	PUNCT
biomedich-205	335	1	progress	progress	NOUN
biomedich-205	335	2	in	in	ADP
biomedich-205	335	3	cardiovascular	cardiovascular	ADJ
biomedich-205	335	4	diseases	disease	NOUN
biomedich-205	335	5	,	,	PUNCT
biomedich-205	335	6	58(1	58(1	NUM
biomedich-205	335	7	)	)	PUNCT
biomedich-205	335	8	,	,	PUNCT
biomedich-205	335	9	19–31	19–31	NUM
biomedich-205	335	10	.	.	PUNCT
biomedich-205	336	1	https://doi.org/10.1016/j.pcad.2015.04.004	https://doi.org/10.1016/j.pcad.2015.04.004	PROPN
biomedich-205	336	2	k.r	k.r	PROPN
biomedich-205	336	3	.	.	PROPN
biomedich-205	336	4	,	,	PUNCT
biomedich-205	336	5	w.	w.	PROPN
biomedich-205	336	6	,	,	PUNCT
biomedich-205	336	7	k.r	k.r	PROPN
biomedich-205	336	8	.	.	PROPN
biomedich-205	336	9	,	,	PUNCT
biomedich-205	336	10	t.	t.	PROPN
biomedich-205	336	11	,	,	PUNCT
biomedich-205	336	12	j.a	j.a	PROPN
biomedich-205	336	13	.	.	PROPN
biomedich-205	336	14	,	,	PUNCT
biomedich-205	336	15	r.	r.	PROPN
biomedich-205	336	16	,	,	PUNCT
biomedich-205	336	17	m.p	m.p	PROPN
biomedich-205	336	18	.	.	PROPN
biomedich-205	336	19	,	,	PUNCT
biomedich-205	336	20	r.	r.	PROPN
biomedich-205	336	21	,	,	PUNCT
biomedich-205	336	22	n.j	n.j	PROPN
biomedich-205	336	23	.	.	PROPN
biomedich-205	336	24	,	,	PUNCT
biomedich-205	336	25	m.	m.	NOUN
biomedich-205	336	26	,	,	PUNCT
biomedich-205	336	27	j.f	j.f	PROPN
biomedich-205	336	28	.	.	PROPN
biomedich-205	336	29	,	,	PUNCT
biomedich-205	336	30	f.	f.	PROPN
biomedich-205	336	31	,	,	PUNCT
biomedich-205	336	32	j.d	j.d	PROPN
biomedich-205	336	33	.	.	PROPN
biomedich-205	336	34	,	,	PUNCT
biomedich-205	336	35	c.	c.	PROPN
biomedich-205	336	36	,	,	PUNCT
biomedich-205	336	37	t.-a	t.-a	PROPN
biomedich-205	336	38	.	.	PROPN
biomedich-205	336	39	,	,	PUNCT
biomedich-205	336	40	n.	n.	PROPN
biomedich-205	336	41	,	,	PUNCT
biomedich-205	336	42	c.d	c.d	PROPN
biomedich-205	336	43	.	.	PROPN
biomedich-205	336	44	,	,	PUNCT
biomedich-205	336	45	f.	f.	PROPN
biomedich-205	336	46	,	,	PUNCT
biomedich-205	336	47	s.a	s.a	PROPN
biomedich-205	336	48	.	.	PROPN
biomedich-205	336	49	,	,	PUNCT
biomedich-205	336	50	t.	t.	PROPN
biomedich-205	336	51	,	,	PUNCT
biomedich-205	336	52	&	&	CCONJ
biomedich-205	336	53	m.s	m.s	PROPN
biomedich-205	336	54	.	.	PROPN
biomedich-205	336	55	,	,	PUNCT
biomedich-205	336	56	c.	c.	PROPN
biomedich-205	336	57	(	(	PUNCT
biomedich-205	336	58	2014	2014	NUM
biomedich-205	336	59	)	)	PUNCT
biomedich-205	336	60	.	.	PUNCT
biomedich-205	337	1	pcsk9	pcsk9	PROPN
biomedich-205	337	2	is	be	AUX
biomedich-205	337	3	a	a	DET
biomedich-205	337	4	critical	critical	ADJ
biomedich-205	337	5	regulator	regulator	NOUN
biomedich-205	337	6	of	of	ADP
biomedich-205	337	7	the	the	DET
biomedich-205	337	8	innate	innate	ADJ
biomedich-205	337	9	immune	immune	ADJ
biomedich-205	337	10	response	response	NOUN
biomedich-205	337	11	and	and	CCONJ
biomedich-205	337	12	septic	septic	ADJ
biomedich-205	337	13	shock	shock	NOUN
biomedich-205	337	14	outcome	outcome	NOUN
biomedich-205	337	15	.	.	PUNCT
biomedich-205	338	1	science	science	NOUN
biomedich-205	338	2	translational	translational	ADJ
biomedich-205	338	3	medicine	medicine	NOUN
biomedich-205	338	4	,	,	PUNCT
biomedich-205	338	5	6(258	6(258	NUM
biomedich-205	338	6	)	)	PUNCT
biomedich-205	338	7	,	,	PUNCT
biomedich-205	338	8	258ra143	258ra143	PROPN
biomedich-205	338	9	.	.	PUNCT
biomedich-205	339	1	http://stm.sciencemag.org/content/6/258/258ra143.full.pdf%0	http://stm.sciencemag.org/content/6/258/258ra143.full.pdf%0	PROPN
biomedich-205	339	2	ahttp://ovidsp.ovid.com/ovidweb.cgi?t=js&page=referenc	ahttp://ovidsp.ovid.com/ovidweb.cgi?t=js&page=referenc	PROPN
biomedich-205	339	3	e&d	e&d	PROPN
biomedich-205	339	4	=	=	SYM
biomedich-205	339	5	emed12&news	emed12&news	NUM
biomedich-205	339	6	=	=	NUM
biomedich-205	339	7	n&an=2014858109	n&an=2014858109	NOUN
biomedich-205	339	8	kanaze	kanaze	PROPN
biomedich-205	339	9	,	,	PUNCT
biomedich-205	339	10	f.	f.	PROPN
biomedich-205	339	11	i.	i.	PROPN
biomedich-205	339	12	,	,	PUNCT
biomedich-205	339	13	bounartzi	bounartzi	NOUN
biomedich-205	339	14	,	,	PUNCT
biomedich-205	339	15	m.	m.	NOUN
biomedich-205	339	16	i.	i.	PROPN
biomedich-205	339	17	,	,	PUNCT
biomedich-205	339	18	georgarakis	georgarakis	PROPN
biomedich-205	339	19	,	,	PUNCT
biomedich-205	339	20	m.	m.	NOUN
biomedich-205	339	21	,	,	PUNCT
biomedich-205	339	22	&	&	CCONJ
biomedich-205	339	23	niopas	niopas	PROPN
biomedich-205	339	24	,	,	PUNCT
biomedich-205	339	25	i.	i.	NOUN
biomedich-205	339	26	(	(	PUNCT
biomedich-205	339	27	2007	2007	NUM
biomedich-205	339	28	)	)	PUNCT
biomedich-205	339	29	.	.	PUNCT
biomedich-205	340	1	pharmacokinetics	pharmacokinetic	NOUN
biomedich-205	340	2	of	of	ADP
biomedich-205	340	3	the	the	DET
biomedich-205	340	4	citrus	citrus	NOUN
biomedich-205	340	5	flavanone	flavanone	NOUN
biomedich-205	340	6	aglycones	aglycone	NOUN
biomedich-205	340	7	hesperetin	hesperetin	VERB
biomedich-205	340	8	and	and	CCONJ
biomedich-205	340	9	naringenin	naringenin	NOUN
biomedich-205	340	10	after	after	ADP
biomedich-205	340	11	single	single	ADJ
biomedich-205	340	12	oral	oral	ADJ
biomedich-205	340	13	administration	administration	NOUN
biomedich-205	340	14	in	in	ADP
biomedich-205	340	15	human	human	ADJ
biomedich-205	340	16	subjects	subject	NOUN
biomedich-205	340	17	.	.	PUNCT
biomedich-205	341	1	european	european	ADJ
biomedich-205	341	2	journal	journal	PROPN
biomedich-205	341	3	of	of	ADP
biomedich-205	341	4	clinical	clinical	ADJ
biomedich-205	341	5	nutrition	nutrition	NOUN
biomedich-205	341	6	,	,	PUNCT
biomedich-205	341	7	61(4	61(4	NUM
biomedich-205	341	8	)	)	PUNCT
biomedich-205	341	9	,	,	PUNCT
biomedich-205	341	10	472–477	472–477	NUM
biomedich-205	341	11	.	.	PUNCT
biomedich-205	342	1	https://doi.org/10.1038/sj.ejcn.1602543	https://doi.org/10.1038/sj.ejcn.1602543	PROPN
biomedich-205	342	2	khera	khera	PROPN
biomedich-205	342	3	,	,	PUNCT
biomedich-205	342	4	a.	a.	PROPN
biomedich-205	342	5	v.	v.	PROPN
biomedich-205	342	6	,	,	PUNCT
biomedich-205	342	7	won	win	VERB
biomedich-205	342	8	,	,	PUNCT
biomedich-205	342	9	h.	h.	PROPN
biomedich-205	342	10	h.	h.	PROPN
biomedich-205	342	11	,	,	PUNCT
biomedich-205	342	12	peloso	peloso	NOUN
biomedich-205	342	13	,	,	PUNCT
biomedich-205	342	14	g.	g.	PROPN
biomedich-205	342	15	m.	m.	PROPN
biomedich-205	342	16	,	,	PUNCT
biomedich-205	342	17	lawson	lawson	PROPN
biomedich-205	342	18	,	,	PUNCT
biomedich-205	342	19	k.	k.	PROPN
biomedich-205	342	20	s.	s.	PROPN
biomedich-205	342	21	,	,	PUNCT
biomedich-205	342	22	bartz	bartz	NOUN
biomedich-205	342	23	,	,	PUNCT
biomedich-205	342	24	t.	t.	NOUN
biomedich-205	342	25	m.	m.	PROPN
biomedich-205	342	26	,	,	PUNCT
biomedich-205	342	27	deng	deng	PROPN
biomedich-205	342	28	,	,	PUNCT
biomedich-205	342	29	x.	x.	PROPN
biomedich-205	342	30	,	,	PUNCT
biomedich-205	342	31	van	van	PROPN
biomedich-205	342	32	leeuwen	leeuwen	PROPN
biomedich-205	342	33	,	,	PUNCT
biomedich-205	342	34	e.	e.	PROPN
biomedich-205	342	35	m.	m.	PROPN
biomedich-205	342	36	,	,	PUNCT
biomedich-205	342	37	natarajan	natarajan	PROPN
biomedich-205	342	38	,	,	PUNCT
biomedich-205	342	39	p.	p.	PROPN
biomedich-205	342	40	,	,	PUNCT
biomedich-205	342	41	emdin	emdin	PROPN
biomedich-205	342	42	,	,	PUNCT
biomedich-205	342	43	c.	c.	PROPN
biomedich-205	342	44	a.	a.	PROPN
biomedich-205	342	45	,	,	PUNCT
biomedich-205	342	46	bick	bick	NOUN
biomedich-205	342	47	,	,	PUNCT
biomedich-205	342	48	a.	a.	NOUN
biomedich-205	342	49	g.	g.	PROPN
biomedich-205	342	50	,	,	PUNCT
biomedich-205	342	51	morrison	morrison	PROPN
biomedich-205	342	52	,	,	PUNCT
biomedich-205	342	53	a.	a.	PROPN
biomedich-205	342	54	c.	c.	PROPN
biomedich-205	342	55	,	,	PUNCT
biomedich-205	342	56	brody	brody	PROPN
biomedich-205	342	57	,	,	PUNCT
biomedich-205	342	58	j.	j.	PROPN
biomedich-205	342	59	a.	a.	PROPN
biomedich-205	342	60	,	,	PUNCT
biomedich-205	342	61	gupta	gupta	PROPN
biomedich-205	342	62	,	,	PUNCT
biomedich-205	342	63	n.	n.	NOUN
biomedich-205	342	64	,	,	PUNCT
biomedich-205	342	65	nomura	nomura	NOUN
biomedich-205	342	66	,	,	PUNCT
biomedich-205	342	67	a.	a.	PROPN
biomedich-205	342	68	,	,	PUNCT
biomedich-205	342	69	kessler	kessler	PROPN
biomedich-205	342	70	,	,	PUNCT
biomedich-205	342	71	t.	t.	PROPN
biomedich-205	342	72	,	,	PUNCT
biomedich-205	342	73	duga	duga	PROPN
biomedich-205	342	74	,	,	PUNCT
biomedich-205	342	75	s.	s.	PROPN
biomedich-205	342	76	,	,	PUNCT
biomedich-205	342	77	bis	bis	PROPN
biomedich-205	342	78	,	,	PUNCT
biomedich-205	342	79	j.	j.	PROPN
biomedich-205	342	80	c.	c.	PROPN
biomedich-205	342	81	,	,	PUNCT
biomedich-205	342	82	van	van	PROPN
biomedich-205	342	83	duijn	duijn	PROPN
biomedich-205	342	84	,	,	PUNCT
biomedich-205	342	85	c.	c.	PROPN
biomedich-205	342	86	m.	m.	NOUN
biomedich-205	342	87	,	,	PUNCT
biomedich-205	342	88	cupples	cupple	NOUN
biomedich-205	342	89	,	,	PUNCT
biomedich-205	342	90	l.	l.	PROPN
biomedich-205	342	91	a.	a.	PROPN
biomedich-205	342	92	,	,	PUNCT
biomedich-205	342	93	…	…	PUNCT
biomedich-205	342	94	kathiresan	kathiresan	PROPN
biomedich-205	342	95	,	,	PUNCT
biomedich-205	342	96	s.	s.	PROPN
biomedich-205	342	97	(	(	PUNCT
biomedich-205	342	98	2016	2016	NUM
biomedich-205	342	99	)	)	PUNCT
biomedich-205	342	100	.	.	PUNCT
biomedich-205	343	1	diagnostic	diagnostic	ADJ
biomedich-205	343	2	yield	yield	NOUN
biomedich-205	343	3	and	and	CCONJ
biomedich-205	343	4	clinical	clinical	ADJ
biomedich-205	343	5	utility	utility	NOUN
biomedich-205	343	6	of	of	ADP
biomedich-205	343	7	sequencing	sequence	VERB
biomedich-205	343	8	familial	familial	ADJ
biomedich-205	343	9	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	343	10	genes	gene	NOUN
biomedich-205	343	11	in	in	ADP
biomedich-205	343	12	patients	patient	NOUN
biomedich-205	343	13	with	with	ADP
biomedich-205	343	14	severe	severe	ADJ
biomedich-205	343	15	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	343	16	.	.	PUNCT
biomedich-205	344	1	in	in	ADP
biomedich-205	344	2	journal	journal	NOUN
biomedich-205	344	3	of	of	ADP
biomedich-205	344	4	the	the	DET
biomedich-205	344	5	american	american	PROPN
biomedich-205	344	6	college	college	PROPN
biomedich-205	344	7	of	of	ADP
biomedich-205	344	8	cardiology	cardiology	NOUN
biomedich-205	344	9	(	(	PUNCT
biomedich-205	344	10	vol	vol	NOUN
biomedich-205	344	11	.	.	PROPN
biomedich-205	344	12	67	67	NUM
biomedich-205	344	13	,	,	PUNCT
biomedich-205	344	14	issue	issue	NOUN
biomedich-205	344	15	22	22	NUM
biomedich-205	344	16	)	)	PUNCT
biomedich-205	344	17	.	.	PUNCT
biomedich-205	345	1	elsevier	elsevier	PROPN
biomedich-205	345	2	ltd	ltd	PROPN
biomedich-205	345	3	.	.	PROPN
biomedich-205	346	1	https://doi.org/10.1016/j.jacc.2016.03.520	https://doi.org/10.1016/j.jacc.2016.03.520	PROPN
biomedich-205	346	2	kim	kim	PROPN
biomedich-205	346	3	,	,	PUNCT
biomedich-205	346	4	s.	s.	PROPN
biomedich-205	346	5	,	,	PUNCT
biomedich-205	346	6	chen	chen	PROPN
biomedich-205	346	7	,	,	PUNCT
biomedich-205	346	8	j.	j.	PROPN
biomedich-205	346	9	,	,	PUNCT
biomedich-205	346	10	cheng	cheng	PROPN
biomedich-205	346	11	,	,	PUNCT
biomedich-205	346	12	t.	t.	PROPN
biomedich-205	346	13	,	,	PUNCT
biomedich-205	346	14	gindulyte	gindulyte	PROPN
biomedich-205	346	15	,	,	PUNCT
biomedich-205	346	16	a.	a.	PROPN
biomedich-205	346	17	,	,	PUNCT
biomedich-205	346	18	he	he	PRON
biomedich-205	346	19	,	,	PUNCT
biomedich-205	346	20	j.	j.	PROPN
biomedich-205	346	21	,	,	PUNCT
biomedich-205	346	22	he	he	PRON
biomedich-205	346	23	,	,	PUNCT
biomedich-205	346	24	s.	s.	PROPN
biomedich-205	346	25	,	,	PUNCT
biomedich-205	346	26	li	li	PROPN
biomedich-205	346	27	,	,	PUNCT
biomedich-205	346	28	q.	q.	PROPN
biomedich-205	346	29	,	,	PUNCT
biomedich-205	346	30	shoemaker	shoemaker	PROPN
biomedich-205	346	31	,	,	PUNCT
biomedich-205	346	32	b.	b.	PROPN
biomedich-205	346	33	a.	a.	PROPN
biomedich-205	346	34	,	,	PUNCT
biomedich-205	346	35	thiessen	thiessen	PROPN
biomedich-205	346	36	,	,	PUNCT
biomedich-205	346	37	p.	p.	NOUN
biomedich-205	346	38	a.	a.	PROPN
biomedich-205	346	39	,	,	PUNCT
biomedich-205	346	40	yu	yu	PROPN
biomedich-205	346	41	,	,	PUNCT
biomedich-205	346	42	b.	b.	PROPN
biomedich-205	346	43	,	,	PUNCT
biomedich-205	346	44	zaslavsky	zaslavsky	PROPN
biomedich-205	346	45	,	,	PUNCT
biomedich-205	346	46	l.	l.	PROPN
biomedich-205	346	47	,	,	PUNCT
biomedich-205	346	48	zhang	zhang	PROPN
biomedich-205	346	49	,	,	PUNCT
biomedich-205	346	50	j.	j.	PROPN
biomedich-205	346	51	,	,	PUNCT
biomedich-205	346	52	&	&	CCONJ
biomedich-205	346	53	bolton	bolton	PROPN
biomedich-205	346	54	,	,	PUNCT
biomedich-205	346	55	e.	e.	PROPN
biomedich-205	346	56	e.	e.	PROPN
biomedich-205	346	57	(	(	PUNCT
biomedich-205	346	58	2021	2021	NUM
biomedich-205	346	59	)	)	PUNCT
biomedich-205	346	60	.	.	PUNCT
biomedich-205	347	1	pubchem	pubchem	NOUN
biomedich-205	347	2	in	in	ADP
biomedich-205	347	3	2021	2021	NUM
biomedich-205	347	4	:	:	PUNCT
biomedich-205	347	5	new	new	ADJ
biomedich-205	347	6	data	datum	NOUN
biomedich-205	347	7	content	content	NOUN
biomedich-205	347	8	and	and	CCONJ
biomedich-205	347	9	improved	improve	VERB
biomedich-205	347	10	web	web	NOUN
biomedich-205	347	11	interfaces	interface	NOUN
biomedich-205	347	12	.	.	PUNCT
biomedich-205	348	1	nucleic	nucleic	ADJ
biomedich-205	348	2	acids	acid	NOUN
biomedich-205	348	3	research	research	NOUN
biomedich-205	348	4	,	,	PUNCT
biomedich-205	348	5	49(d1	49(d1	NUM
biomedich-205	348	6	)	)	PUNCT
biomedich-205	348	7	,	,	PUNCT
biomedich-205	348	8	d1388	d1388	PROPN
biomedich-205	348	9	–	–	PUNCT
biomedich-205	348	10	d1395	d1395	PROPN
biomedich-205	348	11	.	.	PUNCT
biomedich-205	349	1	https://doi.org/10.1093/nar/gkaa971	https://doi.org/10.1093/nar/gkaa971	PROPN
biomedich-205	349	2	koes	koe	NOUN
biomedich-205	349	3	,	,	PUNCT
biomedich-205	349	4	d.	d.	PROPN
biomedich-205	349	5	r.	r.	PROPN
biomedich-205	349	6	,	,	PUNCT
biomedich-205	349	7	&	&	CCONJ
biomedich-205	349	8	camacho	camacho	PROPN
biomedich-205	349	9	,	,	PUNCT
biomedich-205	349	10	c.	c.	PROPN
biomedich-205	349	11	j.	j.	PROPN
biomedich-205	349	12	(	(	PUNCT
biomedich-205	349	13	2012	2012	NUM
biomedich-205	349	14	)	)	PUNCT
biomedich-205	349	15	.	.	PUNCT
biomedich-205	350	1	zincpharmer	zincpharmer	NOUN
biomedich-205	350	2	:	:	PUNCT
biomedich-205	350	3	pharmacophore	pharmacophore	NOUN
biomedich-205	350	4	search	search	NOUN
biomedich-205	350	5	of	of	ADP
biomedich-205	350	6	the	the	DET
biomedich-205	350	7	zinc	zinc	NOUN
biomedich-205	350	8	database	database	NOUN
biomedich-205	350	9	.	.	PUNCT
biomedich-205	351	1	nucleic	nucleic	ADJ
biomedich-205	351	2	acids	acid	NOUN
biomedich-205	351	3	research	research	NOUN
biomedich-205	351	4	,	,	PUNCT
biomedich-205	351	5	40(w1	40(w1	NUM
biomedich-205	351	6	)	)	PUNCT
biomedich-205	351	7	,	,	PUNCT
biomedich-205	351	8	409–414	409–414	NUM
biomedich-205	351	9	.	.	PUNCT
biomedich-205	352	1	https://doi.org/10.1093/nar/gks378	https://doi.org/10.1093/nar/gks378	PROPN
biomedich-205	352	2	langer	langer	NOUN
biomedich-205	352	3	,	,	PUNCT
biomedich-205	352	4	t.	t.	PROPN
biomedich-205	352	5	,	,	PUNCT
biomedich-205	352	6	&	&	CCONJ
biomedich-205	352	7	hoffmann	hoffmann	PROPN
biomedich-205	352	8	,	,	PUNCT
biomedich-205	352	9	r.	r.	PROPN
biomedich-205	352	10	d.	d.	PROPN
biomedich-205	352	11	(	(	PUNCT
biomedich-205	352	12	2008	2008	NUM
biomedich-205	352	13	)	)	PUNCT
biomedich-205	352	14	.	.	PUNCT
biomedich-205	353	1	pharmacophore	pharmacophore	NOUN
biomedich-205	353	2	modelling	modelling	NOUN
biomedich-205	353	3	.	.	PUNCT
biomedich-205	354	1	encyclopedia	encyclopedia	NOUN
biomedich-205	354	2	of	of	ADP
biomedich-205	354	3	molecular	molecular	ADJ
biomedich-205	354	4	pharmacology	pharmacology	NOUN
biomedich-205	354	5	,	,	PUNCT
biomedich-205	354	6	960	960	NUM
biomedich-205	354	7	–	–	PUNCT
biomedich-205	354	8	960	960	NUM
biomedich-205	354	9	.	.	PUNCT
biomedich-205	355	1	https://doi.org/10.1007/978-3-540-38918-7_6434	https://doi.org/10.1007/978-3-540-38918-7_6434	NOUN
biomedich-205	355	2	130	130	NUM
biomedich-205	355	3	biology	biology	NOUN
biomedich-205	355	4	,	,	PUNCT
biomedich-205	355	5	medicine	medicine	NOUN
biomedich-205	355	6	,	,	PUNCT
biomedich-205	355	7	&	&	CCONJ
biomedich-205	355	8	natural	natural	ADJ
biomedich-205	355	9	product	product	NOUN
biomedich-205	355	10	chemistry	chemistry	NOUN
biomedich-205	355	11	11	11	NUM
biomedich-205	355	12	(	(	PUNCT
biomedich-205	355	13	2	2	NUM
biomedich-205	355	14	)	)	PUNCT
biomedich-205	355	15	,	,	PUNCT
biomedich-205	355	16	2022	2022	NUM
biomedich-205	355	17	:	:	PUNCT
biomedich-205	355	18	119	119	NUM
biomedich-205	355	19	-	-	SYM
biomedich-205	355	20	131	131	NUM
biomedich-205	355	21	laskowski	laskowski	NOUN
biomedich-205	355	22	,	,	PUNCT
biomedich-205	355	23	r.	r.	PROPN
biomedich-205	355	24	a.	a.	PROPN
biomedich-205	355	25	,	,	PUNCT
biomedich-205	355	26	jabłońska	jabłońska	PROPN
biomedich-205	355	27	,	,	PUNCT
biomedich-205	355	28	j.	j.	PROPN
biomedich-205	355	29	,	,	PUNCT
biomedich-205	355	30	pravda	pravda	PROPN
biomedich-205	355	31	,	,	PUNCT
biomedich-205	355	32	l.	l.	PROPN
biomedich-205	355	33	,	,	PUNCT
biomedich-205	355	34	vařeková	vařeková	PROPN
biomedich-205	355	35	,	,	PUNCT
biomedich-205	355	36	r.	r.	PROPN
biomedich-205	355	37	s.	s.	PROPN
biomedich-205	355	38	,	,	PUNCT
biomedich-205	355	39	&	&	CCONJ
biomedich-205	355	40	thornton	thornton	PROPN
biomedich-205	355	41	,	,	PUNCT
biomedich-205	355	42	j.	j.	PROPN
biomedich-205	355	43	m.	m.	PROPN
biomedich-205	355	44	(	(	PUNCT
biomedich-205	355	45	2018	2018	NUM
biomedich-205	355	46	)	)	PUNCT
biomedich-205	355	47	.	.	PUNCT
biomedich-205	356	1	pdbsum	pdbsum	NOUN
biomedich-205	356	2	:	:	PUNCT
biomedich-205	356	3	structural	structural	ADJ
biomedich-205	356	4	summaries	summary	NOUN
biomedich-205	356	5	of	of	ADP
biomedich-205	356	6	pdb	pdb	PROPN
biomedich-205	356	7	entries	entry	NOUN
biomedich-205	356	8	.	.	PUNCT
biomedich-205	357	1	protein	protein	NOUN
biomedich-205	357	2	science	science	NOUN
biomedich-205	357	3	,	,	PUNCT
biomedich-205	357	4	27(1	27(1	NUM
biomedich-205	357	5	)	)	PUNCT
biomedich-205	357	6	,	,	PUNCT
biomedich-205	357	7	129–134	129–134	NUM
biomedich-205	357	8	.	.	PUNCT
biomedich-205	358	1	https://doi.org/10.1002/pro.3289	https://doi.org/10.1002/pro.3289	PROPN
biomedich-205	358	2	latimer	latimer	PROPN
biomedich-205	358	3	,	,	PUNCT
biomedich-205	358	4	j.	j.	PROPN
biomedich-205	358	5	,	,	PUNCT
biomedich-205	358	6	batty	batty	PROPN
biomedich-205	358	7	,	,	PUNCT
biomedich-205	358	8	j.	j.	PROPN
biomedich-205	358	9	a.	a.	PROPN
biomedich-205	358	10	,	,	PUNCT
biomedich-205	358	11	neely	neely	PROPN
biomedich-205	358	12	,	,	PUNCT
biomedich-205	358	13	r.	r.	PROPN
biomedich-205	358	14	d.	d.	PROPN
biomedich-205	358	15	g.	g.	PROPN
biomedich-205	358	16	,	,	PUNCT
biomedich-205	358	17	&	&	CCONJ
biomedich-205	358	18	kunadian	kunadian	PROPN
biomedich-205	358	19	,	,	PUNCT
biomedich-205	358	20	v.	v.	PROPN
biomedich-205	358	21	(	(	PUNCT
biomedich-205	358	22	2016	2016	NUM
biomedich-205	358	23	)	)	PUNCT
biomedich-205	358	24	.	.	PUNCT
biomedich-205	359	1	pcsk9	pcsk9	NOUN
biomedich-205	359	2	inhibitors	inhibitor	NOUN
biomedich-205	359	3	in	in	ADP
biomedich-205	359	4	the	the	DET
biomedich-205	359	5	prevention	prevention	NOUN
biomedich-205	359	6	of	of	ADP
biomedich-205	359	7	cardiovascular	cardiovascular	ADJ
biomedich-205	359	8	disease	disease	NOUN
biomedich-205	359	9	.	.	PUNCT
biomedich-205	360	1	journal	journal	NOUN
biomedich-205	360	2	of	of	ADP
biomedich-205	360	3	thrombosis	thrombosis	NOUN
biomedich-205	360	4	and	and	CCONJ
biomedich-205	360	5	thrombolysis	thrombolysis	NOUN
biomedich-205	360	6	,	,	PUNCT
biomedich-205	360	7	42(3	42(3	NUM
biomedich-205	360	8	)	)	PUNCT
biomedich-205	360	9	,	,	PUNCT
biomedich-205	360	10	405–419	405–419	NUM
biomedich-205	360	11	.	.	PUNCT
biomedich-205	361	1	https://doi.org/10.1007/s11239-016-1364-1	https://doi.org/10.1007/s11239-016-1364-1	NUM
biomedich-205	361	2	leinonen	leinonen	PROPN
biomedich-205	361	3	,	,	PUNCT
biomedich-205	361	4	r.	r.	PROPN
biomedich-205	361	5	,	,	PUNCT
biomedich-205	361	6	garcia	garcia	PROPN
biomedich-205	361	7	diez	diez	PROPN
biomedich-205	361	8	,	,	PUNCT
biomedich-205	361	9	f.	f.	PROPN
biomedich-205	361	10	,	,	PUNCT
biomedich-205	361	11	binns	binns	PROPN
biomedich-205	361	12	,	,	PUNCT
biomedich-205	361	13	d.	d.	PROPN
biomedich-205	361	14	,	,	PUNCT
biomedich-205	361	15	fleischmann	fleischmann	PROPN
biomedich-205	361	16	,	,	PUNCT
biomedich-205	361	17	w.	w.	PROPN
biomedich-205	361	18	,	,	PUNCT
biomedich-205	361	19	lopez	lopez	PROPN
biomedich-205	361	20	,	,	PUNCT
biomedich-205	361	21	r.	r.	PROPN
biomedich-205	361	22	,	,	PUNCT
biomedich-205	361	23	&	&	CCONJ
biomedich-205	361	24	apweiler	apweiler	PROPN
biomedich-205	361	25	,	,	PUNCT
biomedich-205	361	26	r.	r.	PROPN
biomedich-205	361	27	(	(	PUNCT
biomedich-205	361	28	2004	2004	NUM
biomedich-205	361	29	)	)	PUNCT
biomedich-205	361	30	.	.	PUNCT
biomedich-205	362	1	uniprot	uniprot	ADJ
biomedich-205	362	2	archive	archive	NOUN
biomedich-205	362	3	.	.	PUNCT
biomedich-205	363	1	bioinformatics	bioinformatic	NOUN
biomedich-205	363	2	,	,	PUNCT
biomedich-205	363	3	20(17	20(17	NUM
biomedich-205	363	4	)	)	PUNCT
biomedich-205	363	5	,	,	PUNCT
biomedich-205	363	6	3236–3237	3236–3237	NUM
biomedich-205	363	7	.	.	PUNCT
biomedich-205	364	1	https://doi.org/10.1093/bioinformatics/bth191	https://doi.org/10.1093/bioinformatics/bth191	PROPN
biomedich-205	364	2	liu	liu	PROPN
biomedich-205	364	3	,	,	PUNCT
biomedich-205	364	4	l.	l.	PROPN
biomedich-205	364	5	,	,	PUNCT
biomedich-205	364	6	&	&	CCONJ
biomedich-205	364	7	chen	chen	PROPN
biomedich-205	364	8	,	,	PUNCT
biomedich-205	364	9	j.	j.	PROPN
biomedich-205	364	10	(	(	PUNCT
biomedich-205	364	11	2008	2008	NUM
biomedich-205	364	12	)	)	PUNCT
biomedich-205	364	13	.	.	PUNCT
biomedich-205	365	1	solubility	solubility	NOUN
biomedich-205	365	2	of	of	ADP
biomedich-205	365	3	hesperetin	hesperetin	NOUN
biomedich-205	365	4	in	in	ADP
biomedich-205	365	5	various	various	ADJ
biomedich-205	365	6	solvents	solvent	NOUN
biomedich-205	365	7	from	from	ADP
biomedich-205	365	8	(	(	PUNCT
biomedich-205	365	9	288.2	288.2	NUM
biomedich-205	365	10	to	to	PART
biomedich-205	365	11	323.2	323.2	NUM
biomedich-205	365	12	)	)	PUNCT
biomedich-205	365	13	k.	k.	PROPN
biomedich-205	365	14	journal	journal	PROPN
biomedich-205	365	15	of	of	ADP
biomedich-205	365	16	chemical	chemical	PROPN
biomedich-205	365	17	and	and	CCONJ
biomedich-205	365	18	engineering	engineering	NOUN
biomedich-205	365	19	data	datum	NOUN
biomedich-205	365	20	,	,	PUNCT
biomedich-205	365	21	53(7	53(7	NUM
biomedich-205	365	22	)	)	PUNCT
biomedich-205	365	23	,	,	PUNCT
biomedich-205	365	24	1649–1650	1649–1650	NUM
biomedich-205	365	25	.	.	PUNCT
biomedich-205	366	1	https://doi.org/10.1021/je800078j	https://doi.org/10.1021/je800078j	PROPN
biomedich-205	366	2	lonn	lonn	PROPN
biomedich-205	366	3	,	,	PUNCT
biomedich-205	366	4	e.	e.	PROPN
biomedich-205	366	5	(	(	PUNCT
biomedich-205	366	6	2001	2001	NUM
biomedich-205	366	7	)	)	PUNCT
biomedich-205	366	8	.	.	PUNCT
biomedich-205	367	1	antiatherosclerotic	antiatherosclerotic	ADJ
biomedich-205	367	2	effects	effect	NOUN
biomedich-205	367	3	of	of	ADP
biomedich-205	367	4	ace	ace	ADJ
biomedich-205	367	5	inhibitors	inhibitor	NOUN
biomedich-205	367	6	:	:	PUNCT
biomedich-205	367	7	where	where	SCONJ
biomedich-205	367	8	are	be	AUX
biomedich-205	367	9	we	we	PRON
biomedich-205	367	10	now	now	ADV
biomedich-205	367	11	?	?	PUNCT
biomedich-205	368	1	american	american	ADJ
biomedich-205	368	2	journal	journal	PROPN
biomedich-205	368	3	of	of	ADP
biomedich-205	368	4	cardiovascular	cardiovascular	ADJ
biomedich-205	368	5	drugs	drug	NOUN
biomedich-205	368	6	,	,	PUNCT
biomedich-205	368	7	1(5	1(5	NUM
biomedich-205	368	8	)	)	PUNCT
biomedich-205	368	9	,	,	PUNCT
biomedich-205	368	10	315–320	315–320	NUM
biomedich-205	368	11	.	.	PUNCT
biomedich-205	369	1	https://doi.org/10.2165/00129784-200101050-00001	https://doi.org/10.2165/00129784-200101050-00001	PROPN
biomedich-205	369	2	lovering	lovering	NOUN
biomedich-205	369	3	,	,	PUNCT
biomedich-205	369	4	f.	f.	PROPN
biomedich-205	369	5	,	,	PUNCT
biomedich-205	369	6	bikker	bikker	PROPN
biomedich-205	369	7	,	,	PUNCT
biomedich-205	369	8	j.	j.	PROPN
biomedich-205	369	9	,	,	PUNCT
biomedich-205	369	10	&	&	CCONJ
biomedich-205	369	11	humblet	humblet	PROPN
biomedich-205	369	12	,	,	PUNCT
biomedich-205	369	13	c.	c.	PROPN
biomedich-205	369	14	(	(	PUNCT
biomedich-205	369	15	2009	2009	NUM
biomedich-205	369	16	)	)	PUNCT
biomedich-205	369	17	.	.	PUNCT
biomedich-205	370	1	escape	escape	VERB
biomedich-205	370	2	from	from	ADP
biomedich-205	370	3	flatland	flatland	NOUN
biomedich-205	370	4	:	:	PUNCT
biomedich-205	370	5	increasing	increase	VERB
biomedich-205	370	6	saturation	saturation	NOUN
biomedich-205	370	7	as	as	ADP
biomedich-205	370	8	an	an	DET
biomedich-205	370	9	approach	approach	NOUN
biomedich-205	370	10	to	to	ADP
biomedich-205	370	11	improving	improve	VERB
biomedich-205	370	12	clinical	clinical	ADJ
biomedich-205	370	13	success	success	NOUN
biomedich-205	370	14	.	.	PUNCT
biomedich-205	371	1	journal	journal	NOUN
biomedich-205	371	2	of	of	ADP
biomedich-205	371	3	medicinal	medicinal	ADJ
biomedich-205	371	4	chemistry	chemistry	NOUN
biomedich-205	371	5	,	,	PUNCT
biomedich-205	371	6	52(21	52(21	NUM
biomedich-205	371	7	)	)	PUNCT
biomedich-205	371	8	,	,	PUNCT
biomedich-205	371	9	6752–6756	6752–6756	NUM
biomedich-205	371	10	.	.	PUNCT
biomedich-205	372	1	https://doi.org/10.1021/jm901241e	https://doi.org/10.1021/jm901241e	PROPN
biomedich-205	372	2	mahley	mahley	PROPN
biomedich-205	372	3	,	,	PUNCT
biomedich-205	372	4	r.	r.	PROPN
biomedich-205	372	5	w.	w.	PROPN
biomedich-205	372	6	(	(	PUNCT
biomedich-205	372	7	2016	2016	NUM
biomedich-205	372	8	)	)	PUNCT
biomedich-205	372	9	.	.	PUNCT
biomedich-205	373	1	apolipoprotein	apolipoprotein	ADJ
biomedich-205	373	2	e	e	NOUN
biomedich-205	373	3	:	:	PUNCT
biomedich-205	373	4	from	from	ADP
biomedich-205	373	5	cardiovascular	cardiovascular	ADJ
biomedich-205	373	6	disease	disease	NOUN
biomedich-205	373	7	to	to	ADP
biomedich-205	373	8	neurodegenerative	neurodegenerative	ADJ
biomedich-205	373	9	disorders	disorder	NOUN
biomedich-205	373	10	.	.	PUNCT
biomedich-205	374	1	journal	journal	NOUN
biomedich-205	374	2	of	of	ADP
biomedich-205	374	3	molecular	molecular	ADJ
biomedich-205	374	4	medicine	medicine	NOUN
biomedich-205	374	5	,	,	PUNCT
biomedich-205	374	6	94(7	94(7	NOUN
biomedich-205	374	7	)	)	PUNCT
biomedich-205	374	8	,	,	PUNCT
biomedich-205	374	9	739–746	739–746	NUM
biomedich-205	374	10	.	.	PUNCT
biomedich-205	375	1	https://doi.org/10.1007/s00109016-1427-y	https://doi.org/10.1007/s00109016-1427-y	DET
biomedich-205	375	2	maxwell	maxwell	PROPN
biomedich-205	375	3	,	,	PUNCT
biomedich-205	375	4	k.	k.	PROPN
biomedich-205	375	5	n.	n.	PROPN
biomedich-205	375	6	,	,	PUNCT
biomedich-205	375	7	soccio	soccio	PROPN
biomedich-205	375	8	,	,	PUNCT
biomedich-205	375	9	r.	r.	PROPN
biomedich-205	375	10	e.	e.	PROPN
biomedich-205	375	11	,	,	PUNCT
biomedich-205	375	12	duncan	duncan	PROPN
biomedich-205	375	13	,	,	PUNCT
biomedich-205	375	14	e.	e.	PROPN
biomedich-205	375	15	m.	m.	PROPN
biomedich-205	375	16	,	,	PUNCT
biomedich-205	375	17	sehayek	sehayek	PROPN
biomedich-205	375	18	,	,	PUNCT
biomedich-205	375	19	e.	e.	PROPN
biomedich-205	375	20	,	,	PUNCT
biomedich-205	375	21	&	&	CCONJ
biomedich-205	375	22	breslow	breslow	PROPN
biomedich-205	375	23	,	,	PUNCT
biomedich-205	375	24	j.	j.	PROPN
biomedich-205	375	25	l.	l.	PROPN
biomedich-205	375	26	(	(	PUNCT
biomedich-205	375	27	2003	2003	NUM
biomedich-205	375	28	)	)	PUNCT
biomedich-205	375	29	.	.	PUNCT
biomedich-205	376	1	novel	novel	PROPN
biomedich-205	376	2	putative	putative	ADJ
biomedich-205	376	3	srebp	srebp	NOUN
biomedich-205	376	4	and	and	CCONJ
biomedich-205	376	5	lxr	lxr	PROPN
biomedich-205	376	6	target	target	NOUN
biomedich-205	376	7	genes	gene	NOUN
biomedich-205	376	8	identified	identify	VERB
biomedich-205	376	9	by	by	ADP
biomedich-205	376	10	microarray	microarray	NOUN
biomedich-205	376	11	analysis	analysis	NOUN
biomedich-205	376	12	in	in	ADP
biomedich-205	376	13	liver	liver	NOUN
biomedich-205	376	14	of	of	ADP
biomedich-205	376	15	cholesterolfed	cholesterolfed	ADJ
biomedich-205	376	16	mice	mouse	NOUN
biomedich-205	376	17	.	.	PUNCT
biomedich-205	377	1	journal	journal	PROPN
biomedich-205	377	2	of	of	ADP
biomedich-205	377	3	lipid	lipid	PROPN
biomedich-205	377	4	research	research	NOUN
biomedich-205	377	5	,	,	PUNCT
biomedich-205	377	6	44(11	44(11	NUM
biomedich-205	377	7	)	)	PUNCT
biomedich-205	377	8	,	,	PUNCT
biomedich-205	377	9	2109–2119	2109–2119	NUM
biomedich-205	377	10	.	.	PUNCT
biomedich-205	378	1	https://doi.org/10.1194/jlr.m300203-jlr200	https://doi.org/10.1194/jlr.m300203-jlr200	PROPN
biomedich-205	378	2	mcnutt	mcnutt	PROPN
biomedich-205	378	3	,	,	PUNCT
biomedich-205	378	4	m.	m.	PROPN
biomedich-205	378	5	c.	c.	PROPN
biomedich-205	378	6	,	,	PUNCT
biomedich-205	378	7	lagace	lagace	NOUN
biomedich-205	378	8	,	,	PUNCT
biomedich-205	378	9	t.	t.	NOUN
biomedich-205	378	10	a.	a.	PROPN
biomedich-205	378	11	,	,	PUNCT
biomedich-205	378	12	&	&	CCONJ
biomedich-205	378	13	horton	horton	PROPN
biomedich-205	378	14	,	,	PUNCT
biomedich-205	378	15	j.	j.	PROPN
biomedich-205	378	16	d.	d.	PROPN
biomedich-205	378	17	(	(	PUNCT
biomedich-205	378	18	2007	2007	NUM
biomedich-205	378	19	)	)	PUNCT
biomedich-205	378	20	.	.	PUNCT
biomedich-205	379	1	catalytic	catalytic	ADJ
biomedich-205	379	2	activity	activity	NOUN
biomedich-205	379	3	is	be	AUX
biomedich-205	379	4	not	not	PART
biomedich-205	379	5	required	require	VERB
biomedich-205	379	6	for	for	ADP
biomedich-205	379	7	secreted	secrete	VERB
biomedich-205	379	8	pcsk9	pcsk9	NOUN
biomedich-205	379	9	to	to	PART
biomedich-205	379	10	reduce	reduce	VERB
biomedich-205	379	11	low	low	ADJ
biomedich-205	379	12	density	density	NOUN
biomedich-205	379	13	lipoprotein	lipoprotein	ADJ
biomedich-205	379	14	receptors	receptor	NOUN
biomedich-205	379	15	in	in	ADP
biomedich-205	379	16	hepg2	hepg2	NOUN
biomedich-205	379	17	cells	cell	NOUN
biomedich-205	379	18	.	.	PUNCT
biomedich-205	380	1	journal	journal	NOUN
biomedich-205	380	2	of	of	ADP
biomedich-205	380	3	biological	biological	ADJ
biomedich-205	380	4	chemistry	chemistry	NOUN
biomedich-205	380	5	,	,	PUNCT
biomedich-205	380	6	282(29	282(29	NUM
biomedich-205	380	7	)	)	PUNCT
biomedich-205	380	8	,	,	PUNCT
biomedich-205	380	9	20799–20803	20799–20803	NUM
biomedich-205	380	10	.	.	PUNCT
biomedich-205	381	1	https://doi.org/10.1074/jbc.c700095200	https://doi.org/10.1074/jbc.c700095200	X
biomedich-205	381	2	petrilli	petrilli	PROPN
biomedich-205	381	3	,	,	PUNCT
biomedich-205	381	4	w.	w.	PROPN
biomedich-205	381	5	l.	l.	PROPN
biomedich-205	381	6	,	,	PUNCT
biomedich-205	381	7	adam	adam	PROPN
biomedich-205	381	8	,	,	PUNCT
biomedich-205	381	9	g.	g.	PROPN
biomedich-205	381	10	c.	c.	PROPN
biomedich-205	381	11	,	,	PUNCT
biomedich-205	381	12	erdmann	erdmann	PROPN
biomedich-205	381	13	,	,	PUNCT
biomedich-205	381	14	r.	r.	PROPN
biomedich-205	381	15	s.	s.	PROPN
biomedich-205	381	16	,	,	PUNCT
biomedich-205	381	17	abeywickrema	abeywickrema	NOUN
biomedich-205	381	18	,	,	PUNCT
biomedich-205	381	19	p.	p.	NOUN
biomedich-205	381	20	,	,	PUNCT
biomedich-205	381	21	agnani	agnani	PROPN
biomedich-205	381	22	,	,	PUNCT
biomedich-205	381	23	v.	v.	ADV
biomedich-205	381	24	,	,	PUNCT
biomedich-205	381	25	ai	ai	VERB
biomedich-205	381	26	,	,	PUNCT
biomedich-205	381	27	x.	x.	NOUN
biomedich-205	381	28	,	,	PUNCT
biomedich-205	381	29	baysarowich	baysarowich	PROPN
biomedich-205	381	30	,	,	PUNCT
biomedich-205	381	31	j.	j.	PROPN
biomedich-205	381	32	,	,	PUNCT
biomedich-205	381	33	byrne	byrne	PROPN
biomedich-205	381	34	,	,	PUNCT
biomedich-205	381	35	n.	n.	PROPN
biomedich-205	381	36	,	,	PUNCT
biomedich-205	381	37	caldwell	caldwell	PROPN
biomedich-205	381	38	,	,	PUNCT
biomedich-205	381	39	j.	j.	PROPN
biomedich-205	381	40	p.	p.	PROPN
biomedich-205	381	41	,	,	PUNCT
biomedich-205	381	42	chang	chang	PROPN
biomedich-205	381	43	,	,	PUNCT
biomedich-205	381	44	w.	w.	PROPN
biomedich-205	381	45	,	,	PUNCT
biomedich-205	381	46	dinunzio	dinunzio	PROPN
biomedich-205	381	47	,	,	PUNCT
biomedich-205	381	48	e.	e.	PROPN
biomedich-205	381	49	,	,	PUNCT
biomedich-205	381	50	feng	feng	PROPN
biomedich-205	381	51	,	,	PUNCT
biomedich-205	381	52	z.	z.	PROPN
biomedich-205	381	53	,	,	PUNCT
biomedich-205	381	54	ford	ford	PROPN
biomedich-205	381	55	,	,	PUNCT
biomedich-205	381	56	r.	r.	PROPN
biomedich-205	381	57	,	,	PUNCT
biomedich-205	381	58	ha	ha	INTJ
biomedich-205	381	59	,	,	PUNCT
biomedich-205	381	60	s.	s.	PROPN
biomedich-205	381	61	,	,	PUNCT
biomedich-205	381	62	huang	huang	PROPN
biomedich-205	381	63	,	,	PUNCT
biomedich-205	381	64	y.	y.	PROPN
biomedich-205	381	65	,	,	PUNCT
biomedich-205	381	66	hubbard	hubbard	PROPN
biomedich-205	381	67	,	,	PUNCT
biomedich-205	381	68	b.	b.	PROPN
biomedich-205	381	69	,	,	PUNCT
biomedich-205	381	70	johnston	johnston	PROPN
biomedich-205	381	71	,	,	PUNCT
biomedich-205	381	72	j.	j.	PROPN
biomedich-205	381	73	m.	m.	PROPN
biomedich-205	381	74	,	,	PUNCT
biomedich-205	381	75	kavana	kavana	PROPN
biomedich-205	381	76	,	,	PUNCT
biomedich-205	381	77	m.	m.	NOUN
biomedich-205	381	78	,	,	PUNCT
biomedich-205	381	79	lisnock	lisnock	PROPN
biomedich-205	381	80	,	,	PUNCT
biomedich-205	381	81	j.	j.	PROPN
biomedich-205	381	82	m.	m.	PROPN
biomedich-205	381	83	,	,	PUNCT
biomedich-205	381	84	…	…	PUNCT
biomedich-205	381	85	imbriglio	imbriglio	NOUN
biomedich-205	381	86	,	,	PUNCT
biomedich-205	381	87	j.	j.	PROPN
biomedich-205	381	88	e.	e.	PROPN
biomedich-205	381	89	(	(	PUNCT
biomedich-205	381	90	2020	2020	NUM
biomedich-205	381	91	)	)	PUNCT
biomedich-205	381	92	.	.	PUNCT
biomedich-205	382	1	from	from	ADP
biomedich-205	382	2	screening	screen	VERB
biomedich-205	382	3	to	to	ADP
biomedich-205	382	4	targeted	target	VERB
biomedich-205	382	5	degradation	degradation	NOUN
biomedich-205	382	6	:	:	PUNCT
biomedich-205	382	7	strategies	strategy	NOUN
biomedich-205	382	8	for	for	ADP
biomedich-205	382	9	the	the	DET
biomedich-205	382	10	discovery	discovery	NOUN
biomedich-205	382	11	and	and	CCONJ
biomedich-205	382	12	optimization	optimization	NOUN
biomedich-205	382	13	of	of	ADP
biomedich-205	382	14	small	small	ADJ
biomedich-205	382	15	molecule	molecule	NOUN
biomedich-205	382	16	ligands	ligand	NOUN
biomedich-205	382	17	for	for	ADP
biomedich-205	382	18	pcsk9	pcsk9	NOUN
biomedich-205	382	19	.	.	PUNCT
biomedich-205	383	1	cell	cell	NOUN
biomedich-205	383	2	chemical	chemical	NOUN
biomedich-205	383	3	biology	biology	NOUN
biomedich-205	383	4	,	,	PUNCT
biomedich-205	383	5	27(1	27(1	NUM
biomedich-205	383	6	)	)	PUNCT
biomedich-205	383	7	,	,	PUNCT
biomedich-205	383	8	32	32	NUM
biomedich-205	383	9	-	-	SYM
biomedich-205	383	10	40.e3	40.e3	NUM
biomedich-205	383	11	.	.	PUNCT
biomedich-205	384	1	https://doi.org/10.1016/j.chembiol.2019.10.002	https://doi.org/10.1016/j.chembiol.2019.10.002	NOUN
biomedich-205	384	2	pines	pine	NOUN
biomedich-205	384	3	,	,	PUNCT
biomedich-205	384	4	a.	a.	NOUN
biomedich-205	384	5	,	,	PUNCT
biomedich-205	384	6	&	&	CCONJ
biomedich-205	384	7	fisman	fisman	PROPN
biomedich-205	384	8	,	,	PUNCT
biomedich-205	384	9	e.	e.	PROPN
biomedich-205	384	10	z.	z.	PROPN
biomedich-205	384	11	(	(	PUNCT
biomedich-205	384	12	2003	2003	NUM
biomedich-205	384	13	)	)	PUNCT
biomedich-205	384	14	.	.	PUNCT
biomedich-205	385	1	ace	ace	VERB
biomedich-205	385	2	inhibition	inhibition	NOUN
biomedich-205	385	3	with	with	ADP
biomedich-205	385	4	moexipril	moexipril	NOUN
biomedich-205	385	5	:	:	PUNCT
biomedich-205	385	6	a	a	DET
biomedich-205	385	7	review	review	NOUN
biomedich-205	385	8	of	of	ADP
biomedich-205	385	9	potential	potential	ADJ
biomedich-205	385	10	effects	effect	NOUN
biomedich-205	385	11	beyond	beyond	ADP
biomedich-205	385	12	blood	blood	NOUN
biomedich-205	385	13	pressure	pressure	NOUN
biomedich-205	385	14	control	control	NOUN
biomedich-205	385	15	.	.	PUNCT
biomedich-205	386	1	american	american	ADJ
biomedich-205	386	2	journal	journal	PROPN
biomedich-205	386	3	of	of	ADP
biomedich-205	386	4	cardiovascular	cardiovascular	ADJ
biomedich-205	386	5	drugs	drug	NOUN
biomedich-205	386	6	,	,	PUNCT
biomedich-205	386	7	3(5	3(5	NUM
biomedich-205	386	8	)	)	PUNCT
biomedich-205	386	9	,	,	PUNCT
biomedich-205	386	10	351–360	351–360	NUM
biomedich-205	386	11	.	.	PUNCT
biomedich-205	386	12	https://doi.org/10.2165/00129784-200303050-00006	https://doi.org/10.2165/00129784-200303050-00006	PROPN
biomedich-205	386	13	pitt	pitt	PROPN
biomedich-205	386	14	,	,	PUNCT
biomedich-205	386	15	b.	b.	PROPN
biomedich-205	386	16	(	(	PUNCT
biomedich-205	386	17	1995	1995	NUM
biomedich-205	386	18	)	)	PUNCT
biomedich-205	386	19	.	.	PUNCT
biomedich-205	387	1	potential	potential	ADJ
biomedich-205	387	2	role	role	NOUN
biomedich-205	387	3	of	of	ADP
biomedich-205	387	4	angiotensin	angiotensin	NOUN
biomedich-205	387	5	converting	convert	VERB
biomedich-205	387	6	enzyme	enzyme	NOUN
biomedich-205	387	7	inhibitors	inhibitor	NOUN
biomedich-205	387	8	in	in	ADP
biomedich-205	387	9	the	the	DET
biomedich-205	387	10	treatment	treatment	NOUN
biomedich-205	387	11	of	of	ADP
biomedich-205	387	12	atherosclerosis	atherosclerosis	NOUN
biomedich-205	387	13	.	.	PUNCT
biomedich-205	388	1	european	european	ADJ
biomedich-205	388	2	heart	heart	PROPN
biomedich-205	388	3	journal	journal	PROPN
biomedich-205	388	4	,	,	PUNCT
biomedich-205	388	5	16(suppl	16(suppl	NUM
biomedich-205	388	6	.	.	PUNCT
biomedich-205	388	7	k	k	X
biomedich-205	388	8	)	)	PUNCT
biomedich-205	388	9	,	,	PUNCT
biomedich-205	388	10	49–54	49–54	NUM
biomedich-205	388	11	.	.	PUNCT
biomedich-205	389	1	https://doi.org/10.1093/eurheartj/16.suppl_k.49	https://doi.org/10.1093/eurheartj/16.suppl_k.49	PROPN
biomedich-205	389	2	ra	ra	PROPN
biomedich-205	389	3	,	,	PUNCT
biomedich-205	389	4	l.	l.	PROPN
biomedich-205	389	5	,	,	PUNCT
biomedich-205	389	6	&	&	CCONJ
biomedich-205	389	7	mb	mb	PROPN
biomedich-205	389	8	,	,	PUNCT
biomedich-205	389	9	s.	s.	PROPN
biomedich-205	389	10	(	(	PUNCT
biomedich-205	389	11	2011	2011	NUM
biomedich-205	389	12	)	)	PUNCT
biomedich-205	389	13	.	.	PUNCT
biomedich-205	390	1	ligplot+	ligplot+	PROPN
biomedich-205	390	2	:	:	PUNCT
biomedich-205	390	3	multiple	multiple	ADJ
biomedich-205	390	4	ligand	ligand	ADJ
biomedich-205	390	5	-	-	PUNCT
biomedich-205	390	6	protein	protein	NOUN
biomedich-205	390	7	interaction	interaction	NOUN
biomedich-205	390	8	diagrams	diagram	NOUN
biomedich-205	390	9	for	for	ADP
biomedich-205	390	10	drug	drug	NOUN
biomedich-205	390	11	discovery	discovery	NOUN
biomedich-205	390	12	.	.	PUNCT
biomedich-205	391	1	journal	journal	PROPN
biomedich-205	391	2	of	of	ADP
biomedich-205	391	3	chemical	chemical	ADJ
biomedich-205	391	4	information	information	NOUN
biomedich-205	391	5	and	and	CCONJ
biomedich-205	391	6	modeling	modeling	NOUN
biomedich-205	391	7	,	,	PUNCT
biomedich-205	391	8	51	51	NUM
biomedich-205	391	9	,	,	PUNCT
biomedich-205	391	10	2778–2786	2778–2786	NUM
biomedich-205	391	11	.	.	PUNCT
biomedich-205	392	1	ramharack	ramharack	NOUN
biomedich-205	392	2	,	,	PUNCT
biomedich-205	392	3	p.	p.	PROPN
biomedich-205	392	4	,	,	PUNCT
biomedich-205	392	5	&	&	CCONJ
biomedich-205	392	6	soliman	soliman	PROPN
biomedich-205	392	7	,	,	PUNCT
biomedich-205	392	8	m.	m.	PROPN
biomedich-205	392	9	e.	e.	PROPN
biomedich-205	392	10	s.	s.	PROPN
biomedich-205	392	11	(	(	PUNCT
biomedich-205	392	12	2018	2018	NUM
biomedich-205	392	13	)	)	PUNCT
biomedich-205	392	14	.	.	PUNCT
biomedich-205	393	1	bioinformatics	bioinformatics	NOUN
biomedich-205	393	2	-	-	PUNCT
biomedich-205	393	3	based	base	VERB
biomedich-205	393	4	tools	tool	NOUN
biomedich-205	393	5	in	in	ADP
biomedich-205	393	6	drug	drug	NOUN
biomedich-205	393	7	discovery	discovery	NOUN
biomedich-205	393	8	:	:	PUNCT
biomedich-205	393	9	the	the	DET
biomedich-205	393	10	cartography	cartography	NOUN
biomedich-205	393	11	from	from	ADP
biomedich-205	393	12	single	single	ADJ
biomedich-205	393	13	gene	gene	NOUN
biomedich-205	393	14	to	to	ADP
biomedich-205	393	15	integrative	integrative	ADJ
biomedich-205	393	16	biological	biological	ADJ
biomedich-205	393	17	networks	network	NOUN
biomedich-205	393	18	.	.	PUNCT
biomedich-205	394	1	drug	drug	NOUN
biomedich-205	394	2	discovery	discovery	PROPN
biomedich-205	394	3	today	today	NOUN
biomedich-205	394	4	,	,	PUNCT
biomedich-205	394	5	23(9	23(9	NUM
biomedich-205	394	6	)	)	PUNCT
biomedich-205	394	7	,	,	PUNCT
biomedich-205	394	8	1658–1665	1658–1665	NUM
biomedich-205	394	9	.	.	PUNCT
biomedich-205	395	1	https://doi.org/10.1016/j.drudis.2018.05.041	https://doi.org/10.1016/j.drudis.2018.05.041	PROPN
biomedich-205	395	2	schneidman	schneidman	NOUN
biomedich-205	395	3	-	-	PUNCT
biomedich-205	395	4	duhovny	duhovny	PROPN
biomedich-205	395	5	,	,	PUNCT
biomedich-205	395	6	d.	d.	PROPN
biomedich-205	395	7	,	,	PUNCT
biomedich-205	395	8	dror	dror	PROPN
biomedich-205	395	9	,	,	PUNCT
biomedich-205	395	10	o.	o.	NOUN
biomedich-205	395	11	,	,	PUNCT
biomedich-205	395	12	inbar	inbar	NOUN
biomedich-205	395	13	,	,	PUNCT
biomedich-205	395	14	y.	y.	PROPN
biomedich-205	395	15	,	,	PUNCT
biomedich-205	395	16	nussinov	nussinov	PROPN
biomedich-205	395	17	,	,	PUNCT
biomedich-205	395	18	r.	r.	PROPN
biomedich-205	395	19	,	,	PUNCT
biomedich-205	395	20	&	&	CCONJ
biomedich-205	395	21	wolfson	wolfson	PROPN
biomedich-205	395	22	,	,	PUNCT
biomedich-205	395	23	h.	h.	PROPN
biomedich-205	395	24	j.	j.	PROPN
biomedich-205	395	25	(	(	PUNCT
biomedich-205	395	26	2008	2008	NUM
biomedich-205	395	27	)	)	PUNCT
biomedich-205	395	28	.	.	PUNCT
biomedich-205	396	1	deterministic	deterministic	ADJ
biomedich-205	396	2	pharmacophore	pharmacophore	NOUN
biomedich-205	396	3	detection	detection	NOUN
biomedich-205	396	4	via	via	ADP
biomedich-205	396	5	multiple	multiple	ADJ
biomedich-205	396	6	flexible	flexible	ADJ
biomedich-205	396	7	alignment	alignment	NOUN
biomedich-205	396	8	of	of	ADP
biomedich-205	396	9	drug	drug	NOUN
biomedich-205	396	10	-	-	PUNCT
biomedich-205	396	11	like	like	ADJ
biomedich-205	396	12	molecules	molecule	NOUN
biomedich-205	396	13	.	.	PUNCT
biomedich-205	397	1	journal	journal	NOUN
biomedich-205	397	2	of	of	ADP
biomedich-205	397	3	computational	computational	ADJ
biomedich-205	397	4	biology	biology	NOUN
biomedich-205	397	5	,	,	PUNCT
biomedich-205	397	6	15(7	15(7	NUM
biomedich-205	397	7	)	)	PUNCT
biomedich-205	397	8	,	,	PUNCT
biomedich-205	397	9	737	737	NUM
biomedich-205	397	10	–	–	SYM
biomedich-205	397	11	754	754	NUM
biomedich-205	397	12	.	.	PUNCT
biomedich-205	398	1	https://doi.org/10.1089/cmb.2007.0130	https://doi.org/10.1089/cmb.2007.0130	ADJ
biomedich-205	398	2	seidah	seidah	NOUN
biomedich-205	398	3	,	,	PUNCT
biomedich-205	398	4	n.	n.	PROPN
biomedich-205	398	5	g.	g.	PROPN
biomedich-205	398	6	,	,	PUNCT
biomedich-205	398	7	abifadel	abifadel	PROPN
biomedich-205	398	8	,	,	PUNCT
biomedich-205	398	9	m.	m.	NOUN
biomedich-205	398	10	,	,	PUNCT
biomedich-205	398	11	prost	prost	PROPN
biomedich-205	398	12	,	,	PUNCT
biomedich-205	398	13	s.	s.	PROPN
biomedich-205	398	14	,	,	PUNCT
biomedich-205	398	15	boileau	boileau	PROPN
biomedich-205	398	16	,	,	PUNCT
biomedich-205	398	17	c.	c.	PROPN
biomedich-205	398	18	,	,	PUNCT
biomedich-205	398	19	&	&	CCONJ
biomedich-205	398	20	prat	prat	PROPN
biomedich-205	398	21	,	,	PUNCT
biomedich-205	398	22	a.	a.	NOUN
biomedich-205	398	23	(	(	PUNCT
biomedich-205	398	24	2017	2017	NUM
biomedich-205	398	25	)	)	PUNCT
biomedich-205	398	26	.	.	PUNCT
biomedich-205	399	1	the	the	DET
biomedich-205	399	2	proprotein	proprotein	ADJ
biomedich-205	399	3	convertases	convertase	NOUN
biomedich-205	399	4	in	in	ADP
biomedich-205	399	5	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	399	6	and	and	CCONJ
biomedich-205	399	7	cardiovascular	cardiovascular	ADJ
biomedich-205	399	8	diseases	disease	NOUN
biomedich-205	399	9	:	:	PUNCT
biomedich-205	399	10	emphasis	emphasis	NOUN
biomedich-205	399	11	on	on	ADP
biomedich-205	399	12	proprotein	proprotein	PROPN
biomedich-205	399	13	convertase	convertase	PROPN
biomedich-205	399	14	subtilisin	subtilisin	PROPN
biomedich-205	399	15	/	/	SYM
biomedich-205	399	16	kexin	kexin	PROPN
biomedich-205	399	17	9	9	NUM
biomedich-205	399	18	.	.	PUNCT
biomedich-205	399	19	pharmacological	pharmacological	ADJ
biomedich-205	399	20	reviews	review	NOUN
biomedich-205	399	21	,	,	PUNCT
biomedich-205	399	22	69(1	69(1	NUM
biomedich-205	399	23	)	)	PUNCT
biomedich-205	399	24	,	,	PUNCT
biomedich-205	399	25	33–52	33–52	NUM
biomedich-205	399	26	.	.	PUNCT
biomedich-205	400	1	https://doi.org/10.1124/pr.116.012989	https://doi.org/10.1124/pr.116.012989	PROPN
biomedich-205	400	2	semenova	semenova	PROPN
biomedich-205	400	3	,	,	PUNCT
biomedich-205	400	4	a.	a.	PROPN
biomedich-205	400	5	e.	e.	PROPN
biomedich-205	400	6	,	,	PUNCT
biomedich-205	400	7	sergienko	sergienko	NOUN
biomedich-205	400	8	,	,	PUNCT
biomedich-205	400	9	i.	i.	PROPN
biomedich-205	400	10	v.	v.	PROPN
biomedich-205	400	11	,	,	PUNCT
biomedich-205	400	12	garcía	garcía	ADJ
biomedich-205	400	13	-	-	PUNCT
biomedich-205	400	14	giustiniani	giustiniani	NOUN
biomedich-205	400	15	,	,	PUNCT
biomedich-205	400	16	d.	d.	PROPN
biomedich-205	400	17	,	,	PUNCT
biomedich-205	400	18	monserrat	monserrat	PROPN
biomedich-205	400	19	,	,	PUNCT
biomedich-205	400	20	l.	l.	PROPN
biomedich-205	400	21	,	,	PUNCT
biomedich-205	400	22	popova	popova	PROPN
biomedich-205	400	23	,	,	PUNCT
biomedich-205	400	24	a.	a.	PROPN
biomedich-205	400	25	b.	b.	PROPN
biomedich-205	400	26	,	,	PUNCT
biomedich-205	400	27	nozadze	nozadze	PROPN
biomedich-205	400	28	,	,	PUNCT
biomedich-205	400	29	d.	d.	PROPN
biomedich-205	400	30	n.	n.	PROPN
biomedich-205	400	31	,	,	PUNCT
biomedich-205	400	32	&	&	CCONJ
biomedich-205	400	33	ezhov	ezhov	PROPN
biomedich-205	400	34	,	,	PUNCT
biomedich-205	400	35	m.	m.	NOUN
biomedich-205	400	36	v.	v.	PROPN
biomedich-205	400	37	(	(	PUNCT
biomedich-205	400	38	2020	2020	NUM
biomedich-205	400	39	)	)	PUNCT
biomedich-205	400	40	.	.	PUNCT
biomedich-205	401	1	verification	verification	NOUN
biomedich-205	401	2	of	of	ADP
biomedich-205	401	3	underlying	underlie	VERB
biomedich-205	401	4	genetic	genetic	ADJ
biomedich-205	401	5	cause	cause	NOUN
biomedich-205	401	6	in	in	ADP
biomedich-205	401	7	a	a	DET
biomedich-205	401	8	cohort	cohort	NOUN
biomedich-205	401	9	of	of	ADP
biomedich-205	401	10	russian	russian	ADJ
biomedich-205	401	11	patients	patient	NOUN
biomedich-205	401	12	with	with	ADP
biomedich-205	401	13	familial	familial	ADJ
biomedich-205	401	14	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	401	15	using	use	VERB
biomedich-205	401	16	targeted	target	VERB
biomedich-205	401	17	next	next	ADJ
biomedich-205	401	18	generation	generation	NOUN
biomedich-205	401	19	sequencing	sequence	VERB
biomedich-205	401	20	.	.	PUNCT
biomedich-205	402	1	journal	journal	NOUN
biomedich-205	402	2	of	of	ADP
biomedich-205	402	3	cardiovascular	cardiovascular	ADJ
biomedich-205	402	4	development	development	NOUN
biomedich-205	402	5	and	and	CCONJ
biomedich-205	402	6	disease	disease	NOUN
biomedich-205	402	7	,	,	PUNCT
biomedich-205	402	8	7(2	7(2	NUM
biomedich-205	402	9	)	)	PUNCT
biomedich-205	402	10	.	.	PUNCT
biomedich-205	403	1	https://doi.org/10.3390/jcdd7020016	https://doi.org/10.3390/jcdd7020016	PROPN
biomedich-205	403	2	shelness	shelness	PROPN
biomedich-205	403	3	,	,	PUNCT
biomedich-205	403	4	g.	g.	PROPN
biomedich-205	403	5	s.	s.	PROPN
biomedich-205	403	6	,	,	PUNCT
biomedich-205	403	7	&	&	CCONJ
biomedich-205	403	8	sellers	seller	NOUN
biomedich-205	403	9	,	,	PUNCT
biomedich-205	403	10	j.	j.	PROPN
biomedich-205	403	11	a.	a.	PROPN
biomedich-205	403	12	(	(	PUNCT
biomedich-205	403	13	2001	2001	NUM
biomedich-205	403	14	)	)	PUNCT
biomedich-205	403	15	.	.	PUNCT
biomedich-205	404	1	very	very	ADV
biomedich-205	404	2	-	-	PUNCT
biomedich-205	404	3	low	low	ADJ
biomedich-205	404	4	-	-	PUNCT
biomedich-205	404	5	density	density	NOUN
biomedich-205	404	6	lipoprotein	lipoprotein	ADJ
biomedich-205	404	7	assembly	assembly	NOUN
biomedich-205	404	8	and	and	CCONJ
biomedich-205	404	9	secretion	secretion	NOUN
biomedich-205	404	10	.	.	PUNCT
biomedich-205	405	1	current	current	ADJ
biomedich-205	405	2	opinion	opinion	NOUN
biomedich-205	405	3	in	in	ADP
biomedich-205	405	4	lipidology	lipidology	NOUN
biomedich-205	405	5	,	,	PUNCT
biomedich-205	405	6	12(2	12(2	NUM
biomedich-205	405	7	)	)	PUNCT
biomedich-205	405	8	,	,	PUNCT
biomedich-205	406	1	151–157	151–157	NUM
biomedich-205	406	2	.	.	PUNCT
biomedich-205	406	3	https://doi.org/10.1097/00041433-200104000-00008	https://doi.org/10.1097/00041433-200104000-00008	NOUN
biomedich-205	406	4	sterling	sterling	NOUN
biomedich-205	406	5	,	,	PUNCT
biomedich-205	406	6	t.	t.	PROPN
biomedich-205	406	7	,	,	PUNCT
biomedich-205	406	8	&	&	CCONJ
biomedich-205	406	9	irwin	irwin	PROPN
biomedich-205	406	10	,	,	PUNCT
biomedich-205	406	11	j.	j.	PROPN
biomedich-205	406	12	j.	j.	PROPN
biomedich-205	406	13	(	(	PUNCT
biomedich-205	406	14	2015	2015	NUM
biomedich-205	406	15	)	)	PUNCT
biomedich-205	406	16	.	.	PUNCT
biomedich-205	407	1	zinc	zinc	NOUN
biomedich-205	407	2	15	15	NUM
biomedich-205	407	3	ligand	ligand	NOUN
biomedich-205	407	4	discovery	discovery	NOUN
biomedich-205	407	5	for	for	ADP
biomedich-205	407	6	everyone	everyone	PRON
biomedich-205	407	7	.	.	PUNCT
biomedich-205	408	1	journal	journal	PROPN
biomedich-205	408	2	of	of	ADP
biomedich-205	408	3	chemical	chemical	ADJ
biomedich-205	408	4	information	information	NOUN
biomedich-205	408	5	and	and	CCONJ
biomedich-205	408	6	modeling	modeling	NOUN
biomedich-205	408	7	,	,	PUNCT
biomedich-205	408	8	55(11	55(11	NUM
biomedich-205	408	9	)	)	PUNCT
biomedich-205	408	10	,	,	PUNCT
biomedich-205	408	11	2324–2337	2324–2337	NUM
biomedich-205	408	12	.	.	PUNCT
biomedich-205	409	1	https://doi.org/10.1021/acs.jcim.5b00559	https://doi.org/10.1021/acs.jcim.5b00559	ADJ
biomedich-205	409	2	ukuku	ukuku	PROPN
biomedich-205	409	3	,	,	PUNCT
biomedich-205	409	4	d.	d.	PROPN
biomedich-205	409	5	o.	o.	PROPN
biomedich-205	409	6	,	,	PUNCT
biomedich-205	409	7	bari	bari	NOUN
biomedich-205	409	8	,	,	PUNCT
biomedich-205	409	9	l.	l.	PROPN
biomedich-205	409	10	,	,	PUNCT
biomedich-205	409	11	&	&	CCONJ
biomedich-205	409	12	kawamoto	kawamoto	PROPN
biomedich-205	409	13	,	,	PUNCT
biomedich-205	409	14	s.	s.	PROPN
biomedich-205	409	15	(	(	PUNCT
biomedich-205	409	16	2012	2012	NUM
biomedich-205	409	17	)	)	PUNCT
biomedich-205	409	18	.	.	PUNCT
biomedich-205	410	1	hydrogen	hydrogen	NOUN
biomedich-205	410	2	peroxide	peroxide	NOUN
biomedich-205	410	3	.	.	PUNCT
biomedich-205	411	1	decontamination	decontamination	NOUN
biomedich-205	411	2	of	of	ADP
biomedich-205	411	3	fresh	fresh	ADJ
biomedich-205	411	4	and	and	CCONJ
biomedich-205	411	5	minimally	minimally	ADV
biomedich-205	411	6	processed	process	VERB
biomedich-205	411	7	produce	produce	NOUN
biomedich-205	411	8	,	,	PUNCT
biomedich-205	411	9	2	2	NUM
biomedich-205	411	10	,	,	PUNCT
biomedich-205	411	11	197–214	197–214	NUM
biomedich-205	411	12	.	.	PUNCT
biomedich-205	412	1	https://doi.org/10.1002/9781118229187.ch11	https://doi.org/10.1002/9781118229187.ch11	VERB
biomedich-205	412	2	urban	urban	PROPN
biomedich-205	412	3	,	,	PUNCT
biomedich-205	412	4	d.	d.	PROPN
biomedich-205	412	5	,	,	PUNCT
biomedich-205	412	6	pöss	pöss	PROPN
biomedich-205	412	7	,	,	PUNCT
biomedich-205	412	8	j.	j.	PROPN
biomedich-205	412	9	,	,	PUNCT
biomedich-205	412	10	böhm	böhm	NOUN
biomedich-205	412	11	,	,	PUNCT
biomedich-205	412	12	m.	m.	NOUN
biomedich-205	412	13	,	,	PUNCT
biomedich-205	412	14	&	&	CCONJ
biomedich-205	412	15	laufs	laufs	PROPN
biomedich-205	412	16	,	,	PUNCT
biomedich-205	412	17	u.	u.	PROPN
biomedich-205	412	18	(	(	PUNCT
biomedich-205	412	19	2013	2013	NUM
biomedich-205	412	20	)	)	PUNCT
biomedich-205	412	21	.	.	PUNCT
biomedich-205	413	1	targeting	target	VERB
biomedich-205	413	2	the	the	DET
biomedich-205	413	3	proprotein	proprotein	PROPN
biomedich-205	413	4	convertase	convertase	PROPN
biomedich-205	413	5	subtilisin	subtilisin	PROPN
biomedich-205	413	6	/	/	SYM
biomedich-205	413	7	kexin	kexin	NOUN
biomedich-205	413	8	type	type	NOUN
biomedich-205	413	9	9	9	NUM
biomedich-205	413	10	for	for	ADP
biomedich-205	413	11	the	the	DET
biomedich-205	413	12	treatment	treatment	NOUN
biomedich-205	413	13	of	of	ADP
biomedich-205	413	14	dyslipidemia	dyslipidemia	NOUN
biomedich-205	413	15	and	and	CCONJ
biomedich-205	413	16	atherosclerosis	atherosclerosis	NOUN
biomedich-205	413	17	.	.	PUNCT
biomedich-205	414	1	journal	journal	NOUN
biomedich-205	414	2	of	of	ADP
biomedich-205	414	3	the	the	DET
biomedich-205	414	4	american	american	PROPN
biomedich-205	414	5	college	college	PROPN
biomedich-205	414	6	of	of	ADP
biomedich-205	414	7	cardiology	cardiology	NOUN
biomedich-205	414	8	,	,	PUNCT
biomedich-205	414	9	62(16	62(16	NUM
biomedich-205	414	10	)	)	PUNCT
biomedich-205	414	11	,	,	PUNCT
biomedich-205	414	12	1401–1408	1401–1408	NUM
biomedich-205	414	13	.	.	PUNCT
biomedich-205	415	1	https://doi.org/10.1016/j.jacc.2013.07.056	https://doi.org/10.1016/j.jacc.2013.07.056	PROPN
biomedich-205	415	2	wan	wan	PROPN
biomedich-205	415	3	,	,	PUNCT
biomedich-205	415	4	q.	q.	PROPN
biomedich-205	415	5	,	,	PUNCT
biomedich-205	415	6	liu	liu	PROPN
biomedich-205	415	7	,	,	PUNCT
biomedich-205	415	8	z.	z.	PROPN
biomedich-205	415	9	,	,	PUNCT
biomedich-205	415	10	yang	yang	PROPN
biomedich-205	415	11	,	,	PUNCT
biomedich-205	415	12	y.	y.	PROPN
biomedich-205	415	13	,	,	PUNCT
biomedich-205	415	14	&	&	CCONJ
biomedich-205	415	15	cui	cui	PROPN
biomedich-205	415	16	,	,	PUNCT
biomedich-205	415	17	x.	x.	NOUN
biomedich-205	415	18	(	(	PUNCT
biomedich-205	415	19	2018	2018	NUM
biomedich-205	415	20	)	)	PUNCT
biomedich-205	415	21	.	.	PUNCT
biomedich-205	416	1	suppressive	suppressive	ADJ
biomedich-205	416	2	effects	effect	NOUN
biomedich-205	416	3	of	of	ADP
biomedich-205	416	4	berberine	berberine	NOUN
biomedich-205	416	5	on	on	ADP
biomedich-205	416	6	atherosclerosis	atherosclerosis	NOUN
biomedich-205	416	7	via	via	ADP
biomedich-205	416	8	downregulating	downregulating	NOUN
biomedich-205	416	9	visfatin	visfatin	NOUN
biomedich-205	416	10	expression	expression	NOUN
biomedich-205	416	11	and	and	CCONJ
biomedich-205	416	12	attenuating	attenuate	VERB
biomedich-205	416	13	visfatin	visfatin	NOUN
biomedich-205	416	14	-	-	PUNCT
biomedich-205	416	15	induced	induce	VERB
biomedich-205	416	16	endothelial	endothelial	ADJ
biomedich-205	416	17	dysfunction	dysfunction	NOUN
biomedich-205	416	18	.	.	PUNCT
biomedich-205	417	1	international	international	ADJ
biomedich-205	417	2	journal	journal	NOUN
biomedich-205	417	3	of	of	ADP
biomedich-205	417	4	molecular	molecular	ADJ
biomedich-205	417	5	medicine	medicine	NOUN
biomedich-205	417	6	,	,	PUNCT
biomedich-205	417	7	41(4	41(4	NUM
biomedich-205	417	8	)	)	PUNCT
biomedich-205	417	9	,	,	PUNCT
biomedich-205	417	10	1939–1948	1939–1948	NUM
biomedich-205	417	11	.	.	PUNCT
biomedich-205	418	1	https://doi.org/10.3892/ijmm.2018.3440	https://doi.org/10.3892/ijmm.2018.3440	PROPN
biomedich-205	418	2	waterhouse	waterhouse	NOUN
biomedich-205	418	3	,	,	PUNCT
biomedich-205	418	4	a.	a.	NOUN
biomedich-205	418	5	,	,	PUNCT
biomedich-205	418	6	bertoni	bertoni	PROPN
biomedich-205	418	7	,	,	PUNCT
biomedich-205	418	8	m.	m.	NOUN
biomedich-205	418	9	,	,	PUNCT
biomedich-205	418	10	bienert	bienert	PROPN
biomedich-205	418	11	,	,	PUNCT
biomedich-205	418	12	s.	s.	PROPN
biomedich-205	418	13	,	,	PUNCT
biomedich-205	418	14	studer	studer	NOUN
biomedich-205	418	15	,	,	PUNCT
biomedich-205	418	16	g.	g.	PROPN
biomedich-205	418	17	,	,	PUNCT
biomedich-205	418	18	tauriello	tauriello	PROPN
biomedich-205	418	19	,	,	PUNCT
biomedich-205	418	20	g.	g.	PROPN
biomedich-205	418	21	,	,	PUNCT
biomedich-205	418	22	gumienny	gumienny	NOUN
biomedich-205	418	23	,	,	PUNCT
biomedich-205	418	24	r.	r.	PROPN
biomedich-205	418	25	,	,	PUNCT
biomedich-205	418	26	heer	heer	PROPN
biomedich-205	418	27	,	,	PUNCT
biomedich-205	418	28	f.	f.	PROPN
biomedich-205	418	29	t.	t.	PROPN
biomedich-205	418	30	,	,	PUNCT
biomedich-205	418	31	de	de	X
biomedich-205	418	32	beer	beer	NOUN
biomedich-205	418	33	,	,	PUNCT
biomedich-205	418	34	t.	t.	PROPN
biomedich-205	418	35	a.	a.	PROPN
biomedich-205	418	36	p.	p.	PROPN
biomedich-205	418	37	,	,	PUNCT
biomedich-205	418	38	rempfer	rempfer	NOUN
biomedich-205	418	39	,	,	PUNCT
biomedich-205	418	40	c.	c.	PROPN
biomedich-205	418	41	,	,	PUNCT
biomedich-205	418	42	bordoli	bordoli	ADV
biomedich-205	418	43	,	,	PUNCT
biomedich-205	418	44	l.	l.	PROPN
biomedich-205	418	45	,	,	PUNCT
biomedich-205	418	46	lepore	lepore	PROPN
biomedich-205	418	47	,	,	PUNCT
biomedich-205	418	48	r.	r.	PROPN
biomedich-205	418	49	,	,	PUNCT
biomedich-205	418	50	&	&	CCONJ
biomedich-205	418	51	schwede	schwede	PROPN
biomedich-205	418	52	,	,	PUNCT
biomedich-205	418	53	t.	t.	PROPN
biomedich-205	418	54	(	(	PUNCT
biomedich-205	418	55	2018	2018	NUM
biomedich-205	418	56	)	)	PUNCT
biomedich-205	418	57	.	.	PUNCT
biomedich-205	419	1	swissmodel	swissmodel	PROPN
biomedich-205	419	2	:	:	PUNCT
biomedich-205	419	3	homology	homology	NOUN
biomedich-205	419	4	modelling	modelling	NOUN
biomedich-205	419	5	of	of	ADP
biomedich-205	419	6	protein	protein	NOUN
biomedich-205	419	7	structures	structure	NOUN
biomedich-205	419	8	and	and	CCONJ
biomedich-205	419	9	complexes	complex	NOUN
biomedich-205	419	10	.	.	PUNCT
biomedich-205	420	1	nucleic	nucleic	ADJ
biomedich-205	420	2	acids	acid	NOUN
biomedich-205	420	3	research	research	NOUN
biomedich-205	420	4	,	,	PUNCT
biomedich-205	420	5	46(w1	46(w1	NUM
biomedich-205	420	6	)	)	PUNCT
biomedich-205	420	7	,	,	PUNCT
biomedich-205	420	8	w296	w296	NUM
biomedich-205	420	9	–	–	PUNCT
biomedich-205	420	10	w303	w303	PROPN
biomedich-205	420	11	.	.	PUNCT
biomedich-205	421	1	https://doi.org/10.1093/nar/gky427	https://doi.org/10.1093/nar/gky427	PROPN
biomedich-205	421	2	wei	wei	PROPN
biomedich-205	421	3	,	,	PUNCT
biomedich-205	421	4	w.	w.	PROPN
biomedich-205	421	5	,	,	PUNCT
biomedich-205	421	6	cherukupalli	cherukupalli	PROPN
biomedich-205	421	7	,	,	PUNCT
biomedich-205	421	8	s.	s.	PROPN
biomedich-205	421	9	,	,	PUNCT
biomedich-205	421	10	jing	jing	PROPN
biomedich-205	421	11	,	,	PUNCT
biomedich-205	421	12	l.	l.	PROPN
biomedich-205	421	13	,	,	PUNCT
biomedich-205	421	14	liu	liu	PROPN
biomedich-205	421	15	,	,	PUNCT
biomedich-205	421	16	x.	x.	PROPN
biomedich-205	421	17	,	,	PUNCT
biomedich-205	421	18	&	&	CCONJ
biomedich-205	421	19	zhan	zhan	PROPN
biomedich-205	421	20	,	,	PUNCT
biomedich-205	421	21	p.	p.	NOUN
biomedich-205	421	22	(	(	PUNCT
biomedich-205	421	23	2020	2020	NUM
biomedich-205	421	24	)	)	PUNCT
biomedich-205	421	25	.	.	PUNCT
biomedich-205	422	1	fsp3	fsp3	ADJ
biomedich-205	422	2	:	:	PUNCT
biomedich-205	422	3	a	a	DET
biomedich-205	422	4	new	new	ADJ
biomedich-205	422	5	parameter	parameter	NOUN
biomedich-205	422	6	for	for	ADP
biomedich-205	422	7	drug	drug	NOUN
biomedich-205	422	8	-	-	PUNCT
biomedich-205	422	9	likeness	likeness	NOUN
biomedich-205	422	10	.	.	PUNCT
biomedich-205	423	1	drug	drug	NOUN
biomedich-205	423	2	discovery	discovery	PROPN
biomedich-205	423	3	today	today	NOUN
biomedich-205	423	4	,	,	PUNCT
biomedich-205	423	5	25(10	25(10	NOUN
biomedich-205	423	6	)	)	PUNCT
biomedich-205	423	7	,	,	PUNCT
biomedich-205	423	8	1839–1845	1839–1845	NUM
biomedich-205	423	9	.	.	PUNCT
biomedich-205	424	1	https://doi.org/10.1016/j.drudis.2020.07.017	https://doi.org/10.1016/j.drudis.2020.07.017	NUM
biomedich-205	424	2	wishart	wishart	PROPN
biomedich-205	424	3	,	,	PUNCT
biomedich-205	424	4	d.	d.	PROPN
biomedich-205	424	5	s.	s.	PROPN
biomedich-205	424	6	(	(	PUNCT
biomedich-205	424	7	2005	2005	NUM
biomedich-205	424	8	)	)	PUNCT
biomedich-205	424	9	.	.	PUNCT
biomedich-205	425	1	bioinformatics	bioinformatic	NOUN
biomedich-205	425	2	in	in	ADP
biomedich-205	425	3	drug	drug	NOUN
biomedich-205	425	4	development	development	NOUN
biomedich-205	425	5	and	and	CCONJ
biomedich-205	425	6	assessment	assessment	NOUN
biomedich-205	425	7	.	.	PUNCT
biomedich-205	426	1	in	in	ADP
biomedich-205	426	2	drug	drug	NOUN
biomedich-205	426	3	metabolism	metabolism	NOUN
biomedich-205	426	4	reviews	review	NOUN
biomedich-205	426	5	(	(	PUNCT
biomedich-205	426	6	vol	vol	NOUN
biomedich-205	426	7	.	.	PUNCT
biomedich-205	426	8	37	37	NUM
biomedich-205	426	9	,	,	PUNCT
biomedich-205	426	10	issue	issue	NOUN
biomedich-205	426	11	2	2	NUM
biomedich-205	426	12	)	)	PUNCT
biomedich-205	426	13	.	.	PUNCT
biomedich-205	427	1	https://doi.org/10.1081/dmr-200055225	https://doi.org/10.1081/dmr-200055225	X
biomedich-205	428	1	xu	xu	INTJ
biomedich-205	428	2	,	,	PUNCT
biomedich-205	428	3	s.	s.	PROPN
biomedich-205	428	4	,	,	PUNCT
biomedich-205	428	5	luo	luo	PROPN
biomedich-205	428	6	,	,	PUNCT
biomedich-205	428	7	s.	s.	PROPN
biomedich-205	428	8	,	,	PUNCT
biomedich-205	428	9	zhu	zhu	PROPN
biomedich-205	428	10	,	,	PUNCT
biomedich-205	428	11	z.	z.	PROPN
biomedich-205	428	12	,	,	PUNCT
biomedich-205	428	13	&	&	CCONJ
biomedich-205	428	14	xu	xu	PROPN
biomedich-205	428	15	,	,	PUNCT
biomedich-205	428	16	j.	j.	PROPN
biomedich-205	428	17	(	(	PUNCT
biomedich-205	428	18	2019	2019	NUM
biomedich-205	428	19	)	)	PUNCT
biomedich-205	428	20	.	.	PUNCT
biomedich-205	429	1	small	small	ADJ
biomedich-205	429	2	molecules	molecule	NOUN
biomedich-205	429	3	as	as	ADP
biomedich-205	429	4	inhibitors	inhibitor	NOUN
biomedich-205	429	5	of	of	ADP
biomedich-205	429	6	pcsk9	pcsk9	NOUN
biomedich-205	429	7	:	:	PUNCT
biomedich-205	429	8	current	current	ADJ
biomedich-205	429	9	status	status	NOUN
biomedich-205	429	10	and	and	CCONJ
biomedich-205	429	11	future	future	ADJ
biomedich-205	429	12	challenges	challenge	NOUN
biomedich-205	429	13	.	.	PUNCT
biomedich-205	430	1	european	european	ADJ
biomedich-205	430	2	journal	journal	PROPN
biomedich-205	430	3	of	of	ADP
biomedich-205	430	4	medicinal	medicinal	ADJ
biomedich-205	430	5	chemistry	chemistry	NOUN
biomedich-205	430	6	,	,	PUNCT
biomedich-205	430	7	162	162	NUM
biomedich-205	430	8	,	,	PUNCT
biomedich-205	430	9	212–233	212–233	NUM
biomedich-205	430	10	.	.	PUNCT
biomedich-205	431	1	https://doi.org/10.1016/j.ejmech.2018.11.011	https://doi.org/10.1016/j.ejmech.2018.11.011	PROPN
biomedich-205	431	2	yamada	yamada	PROPN
biomedich-205	431	3	,	,	PUNCT
biomedich-205	431	4	y.	y.	PROPN
biomedich-205	431	5	,	,	PUNCT
biomedich-205	431	6	gohda	gohda	NOUN
biomedich-205	431	7	,	,	PUNCT
biomedich-205	431	8	s.	s.	PROPN
biomedich-205	431	9	,	,	PUNCT
biomedich-205	431	10	abe	abe	PROPN
biomedich-205	431	11	,	,	PUNCT
biomedich-205	431	12	k.	k.	PROPN
biomedich-205	431	13	,	,	PUNCT
biomedich-205	431	14	togo	togo	PROPN
biomedich-205	431	15	,	,	PUNCT
biomedich-205	431	16	t.	t.	PROPN
biomedich-205	431	17	,	,	PUNCT
biomedich-205	431	18	shimano	shimano	PROPN
biomedich-205	431	19	,	,	PUNCT
biomedich-205	431	20	n.	n.	NOUN
biomedich-205	431	21	,	,	PUNCT
biomedich-205	431	22	sasaki	sasaki	PROPN
biomedich-205	431	23	,	,	PUNCT
biomedich-205	431	24	t.	t.	PROPN
biomedich-205	431	25	,	,	PUNCT
biomedich-205	431	26	tanaka	tanaka	PROPN
biomedich-205	431	27	,	,	PUNCT
biomedich-205	431	28	h.	h.	PROPN
biomedich-205	431	29	,	,	PUNCT
biomedich-205	431	30	ono	ono	PROPN
biomedich-205	431	31	,	,	PUNCT
biomedich-205	431	32	h.	h.	PROPN
biomedich-205	431	33	,	,	PUNCT
biomedich-205	431	34	ohba	ohba	PROPN
biomedich-205	431	35	,	,	PUNCT
biomedich-205	431	36	t.	t.	PROPN
biomedich-205	431	37	,	,	PUNCT
biomedich-205	431	38	kubo	kubo	PROPN
biomedich-205	431	39	,	,	PUNCT
biomedich-205	431	40	s.	s.	PROPN
biomedich-205	431	41	,	,	PUNCT
biomedich-205	431	42	ohkubo	ohkubo	NOUN
biomedich-205	431	43	,	,	PUNCT
biomedich-205	431	44	t.	t.	PROPN
biomedich-205	431	45	,	,	PUNCT
biomedich-205	431	46	&	&	CCONJ
biomedich-205	431	47	sato	sato	PROPN
biomedich-205	431	48	,	,	PUNCT
biomedich-205	431	49	s.	s.	PROPN
biomedich-205	431	50	(	(	PUNCT
biomedich-205	431	51	2017	2017	NUM
biomedich-205	431	52	)	)	PUNCT
biomedich-205	431	53	.	.	PUNCT
biomedich-205	432	1	carbon	carbon	NOUN
biomedich-205	432	2	materials	material	NOUN
biomedich-205	432	3	with	with	ADP
biomedich-205	432	4	controlled	control	VERB
biomedich-205	432	5	edge	edge	NOUN
biomedich-205	432	6	structures	structure	NOUN
biomedich-205	432	7	.	.	PUNCT
biomedich-205	433	1	carbon	carbon	NOUN
biomedich-205	433	2	,	,	PUNCT
biomedich-205	433	3	122(october	122(october	NUM
biomedich-205	433	4	1995	1995	NUM
biomedich-205	433	5	)	)	PUNCT
biomedich-205	433	6	,	,	PUNCT
biomedich-205	433	7	694–701	694–701	NUM
biomedich-205	433	8	.	.	PUNCT
biomedich-205	434	1	https://doi.org/10.1016/j.carbon.2017.07.012	https://doi.org/10.1016/j.carbon.2017.07.012	PROPN
biomedich-205	434	2	yang	yang	PROPN
biomedich-205	434	3	,	,	PUNCT
biomedich-205	434	4	h.	h.	PROPN
biomedich-205	434	5	,	,	PUNCT
biomedich-205	434	6	lou	lou	PROPN
biomedich-205	434	7	,	,	PUNCT
biomedich-205	434	8	c.	c.	PROPN
biomedich-205	434	9	,	,	PUNCT
biomedich-205	434	10	sun	sun	PROPN
biomedich-205	434	11	,	,	PUNCT
biomedich-205	434	12	l.	l.	PROPN
biomedich-205	434	13	,	,	PUNCT
biomedich-205	434	14	li	li	PROPN
biomedich-205	434	15	,	,	PUNCT
biomedich-205	434	16	j.	j.	PROPN
biomedich-205	434	17	,	,	PUNCT
biomedich-205	434	18	cai	cai	PROPN
biomedich-205	434	19	,	,	PUNCT
biomedich-205	434	20	y.	y.	PROPN
biomedich-205	434	21	,	,	PUNCT
biomedich-205	434	22	wang	wang	PROPN
biomedich-205	434	23	,	,	PUNCT
biomedich-205	434	24	z.	z.	PROPN
biomedich-205	434	25	,	,	PUNCT
biomedich-205	434	26	li	li	PROPN
biomedich-205	434	27	,	,	PUNCT
biomedich-205	434	28	w.	w.	PROPN
biomedich-205	434	29	,	,	PUNCT
biomedich-205	434	30	liu	liu	PROPN
biomedich-205	434	31	,	,	PUNCT
biomedich-205	434	32	g.	g.	PROPN
biomedich-205	434	33	,	,	PUNCT
biomedich-205	434	34	&	&	CCONJ
biomedich-205	434	35	tang	tang	PROPN
biomedich-205	434	36	,	,	PUNCT
biomedich-205	434	37	y.	y.	PROPN
biomedich-205	434	38	(	(	PUNCT
biomedich-205	434	39	2019	2019	NUM
biomedich-205	434	40	)	)	PUNCT
biomedich-205	434	41	.	.	PUNCT
biomedich-205	435	1	admetsar	admetsar	ADJ
biomedich-205	435	2	2.0	2.0	NUM
biomedich-205	435	3	:	:	PUNCT
biomedich-205	435	4	web	web	NOUN
biomedich-205	435	5	-	-	NOUN
biomedich-205	435	6	service	service	NOUN
biomedich-205	435	7	for	for	ADP
biomedich-205	435	8	sethuramalingam	sethuramalingam	NOUN
biomedich-205	435	9	et	et	PROPN
biomedich-205	435	10	al	al	PROPN
biomedich-205	435	11	.	.	PROPN
biomedich-205	435	12	–	–	PUNCT
biomedich-205	435	13	identification	identification	NOUN
biomedich-205	435	14	of	of	ADP
biomedich-205	435	15	pcsk9	pcsk9	NOUN
biomedich-205	435	16	inhibitors	inhibitor	VERB
biomedich-205	435	17	131	131	NUM
biomedich-205	435	18	prediction	prediction	NOUN
biomedich-205	435	19	and	and	CCONJ
biomedich-205	435	20	optimization	optimization	NOUN
biomedich-205	435	21	of	of	ADP
biomedich-205	435	22	chemical	chemical	ADJ
biomedich-205	435	23	admet	admet	PROPN
biomedich-205	435	24	properties	property	NOUN
biomedich-205	435	25	.	.	PUNCT
biomedich-205	436	1	bioinformatics	bioinformatic	NOUN
biomedich-205	436	2	,	,	PUNCT
biomedich-205	436	3	35(6	35(6	NUM
biomedich-205	436	4	)	)	PUNCT
biomedich-205	436	5	,	,	PUNCT
biomedich-205	436	6	1067–1069	1067–1069	NUM
biomedich-205	436	7	.	.	PUNCT
biomedich-205	437	1	https://doi.org/10.1093/bioinformatics/bty707	https://doi.org/10.1093/bioinformatics/bty707	NOUN
biomedich-205	437	2	younas	youna	NOUN
biomedich-205	437	3	,	,	PUNCT
biomedich-205	437	4	f.	f.	PROPN
biomedich-205	437	5	,	,	PUNCT
biomedich-205	437	6	aslam	aslam	PROPN
biomedich-205	437	7	,	,	PUNCT
biomedich-205	437	8	b.	b.	PROPN
biomedich-205	437	9	,	,	PUNCT
biomedich-205	437	10	muhammad	muhammad	PROPN
biomedich-205	437	11	,	,	PUNCT
biomedich-205	437	12	f.	f.	PROPN
biomedich-205	437	13	,	,	PUNCT
biomedich-205	437	14	mohsin	mohsin	PROPN
biomedich-205	437	15	,	,	PUNCT
biomedich-205	437	16	m.	m.	NOUN
biomedich-205	437	17	,	,	PUNCT
biomedich-205	437	18	raza	raza	PROPN
biomedich-205	437	19	,	,	PUNCT
biomedich-205	437	20	a.	a.	NOUN
biomedich-205	437	21	,	,	PUNCT
biomedich-205	437	22	faisal	faisal	NOUN
biomedich-205	437	23	,	,	PUNCT
biomedich-205	437	24	m.	m.	NOUN
biomedich-205	437	25	n.	n.	PROPN
biomedich-205	437	26	,	,	PUNCT
biomedich-205	437	27	shamshud	shamshud	PROPN
biomedich-205	437	28	-	-	PUNCT
biomedich-205	437	29	ul	ul	INTJ
biomedich-205	437	30	-	-	PUNCT
biomedich-205	437	31	hassan	hassan	PROPN
biomedich-205	437	32	,	,	PUNCT
biomedich-205	437	33	&	&	CCONJ
biomedich-205	437	34	majeed	majeed	PROPN
biomedich-205	437	35	,	,	PUNCT
biomedich-205	437	36	w.	w.	PROPN
biomedich-205	437	37	(	(	PUNCT
biomedich-205	437	38	2017	2017	NUM
biomedich-205	437	39	)	)	PUNCT
biomedich-205	437	40	.	.	PUNCT
biomedich-205	438	1	haematopoietic	haematopoietic	ADJ
biomedich-205	438	2	effects	effect	NOUN
biomedich-205	438	3	of	of	ADP
biomedich-205	438	4	angelica	angelica	PROPN
biomedich-205	438	5	sinensis	sinensis	NOUN
biomedich-205	438	6	root	root	NOUN
biomedich-205	438	7	cap	cap	NOUN
biomedich-205	438	8	polysaccharides	polysaccharide	NOUN
biomedich-205	438	9	against	against	ADP
biomedich-205	438	10	lisinopril	lisinopril	NOUN
biomedich-205	438	11	-	-	PUNCT
biomedich-205	438	12	induced	induce	VERB
biomedich-205	438	13	anaemia	anaemia	NOUN
biomedich-205	438	14	in	in	ADP
biomedich-205	438	15	albino	albino	NOUN
biomedich-205	438	16	rats	rat	NOUN
biomedich-205	438	17	.	.	PUNCT
biomedich-205	439	1	pharmaceutical	pharmaceutical	ADJ
biomedich-205	439	2	biology	biology	NOUN
biomedich-205	439	3	,	,	PUNCT
biomedich-205	439	4	55(1	55(1	NOUN
biomedich-205	439	5	)	)	PUNCT
biomedich-205	439	6	,	,	PUNCT
biomedich-205	439	7	108–113	108–113	NUM
biomedich-205	439	8	.	.	PUNCT
biomedich-205	440	1	https://doi.org/10.1080/13880209.2016.1230635	https://doi.org/10.1080/13880209.2016.1230635	PROPN
biomedich-205	440	2	zhang	zhang	PROPN
biomedich-205	440	3	,	,	PUNCT
biomedich-205	440	4	d.	d.	PROPN
biomedich-205	440	5	,	,	PUNCT
biomedich-205	440	6	wang	wang	PROPN
biomedich-205	440	7	,	,	PUNCT
biomedich-205	440	8	y.	y.	PROPN
biomedich-205	440	9	,	,	PUNCT
biomedich-205	440	10	yi	yi	PROPN
biomedich-205	440	11	,	,	PUNCT
biomedich-205	440	12	m.	m.	NOUN
biomedich-205	440	13	,	,	PUNCT
biomedich-205	440	14	zhang	zhang	PROPN
biomedich-205	440	15	,	,	PUNCT
biomedich-205	440	16	s.	s.	PROPN
biomedich-205	440	17	,	,	PUNCT
biomedich-205	440	18	&	&	CCONJ
biomedich-205	440	19	wu	wu	PROPN
biomedich-205	440	20	,	,	PUNCT
biomedich-205	440	21	y.	y.	PROPN
biomedich-205	440	22	(	(	PUNCT
biomedich-205	440	23	2020	2020	NUM
biomedich-205	440	24	)	)	PUNCT
biomedich-205	440	25	.	.	PUNCT
biomedich-205	441	1	the	the	DET
biomedich-205	441	2	peroxisome	peroxisome	PROPN
biomedich-205	441	3	proliferator	proliferator	NOUN
biomedich-205	441	4	-	-	PUNCT
biomedich-205	441	5	activated	activate	VERB
biomedich-205	441	6	receptor	receptor	NOUN
biomedich-205	441	7	γ	γ	NOUN
biomedich-205	441	8	agonist	agonist	NOUN
biomedich-205	441	9	pioglitazone	pioglitazone	NOUN
biomedich-205	441	10	protects	protect	VERB
biomedich-205	441	11	vascular	vascular	ADJ
biomedich-205	441	12	endothelial	endothelial	ADJ
biomedich-205	441	13	function	function	NOUN
biomedich-205	441	14	in	in	ADP
biomedich-205	441	15	hypercholesterolemic	hypercholesterolemic	ADJ
biomedich-205	441	16	rats	rat	NOUN
biomedich-205	441	17	by	by	ADP
biomedich-205	441	18	inhibiting	inhibit	VERB
biomedich-205	441	19	myeloperoxidase	myeloperoxidase	NOUN
biomedich-205	441	20	.	.	PUNCT
biomedich-205	442	1	cardiology	cardiology	NOUN
biomedich-205	442	2	research	research	NOUN
biomedich-205	442	3	and	and	CCONJ
biomedich-205	442	4	practice	practice	NOUN
biomedich-205	442	5	,	,	PUNCT
biomedich-205	442	6	2020	2020	NUM
biomedich-205	442	7	.	.	PUNCT
biomedich-205	443	1	https://doi.org/10.1155/2020/1845969	https://doi.org/10.1155/2020/1845969	PROPN
biomedich-205	443	2	zhao	zhao	PROPN
biomedich-205	443	3	,	,	PUNCT
biomedich-205	443	4	p.	p.	PROPN
biomedich-205	443	5	j.	j.	PROPN
biomedich-205	443	6	,	,	PUNCT
biomedich-205	443	7	ban	ban	PROPN
biomedich-205	443	8	,	,	PUNCT
biomedich-205	443	9	m.	m.	PROPN
biomedich-205	443	10	r.	r.	PROPN
biomedich-205	443	11	,	,	PUNCT
biomedich-205	443	12	iacocca	iacocca	NOUN
biomedich-205	443	13	,	,	PUNCT
biomedich-205	443	14	m.	m.	NOUN
biomedich-205	443	15	a.	a.	PROPN
biomedich-205	443	16	,	,	PUNCT
biomedich-205	443	17	mcintyre	mcintyre	PROPN
biomedich-205	443	18	,	,	PUNCT
biomedich-205	443	19	a.	a.	PROPN
biomedich-205	443	20	d.	d.	PROPN
biomedich-205	443	21	,	,	PUNCT
biomedich-205	443	22	wang	wang	PROPN
biomedich-205	443	23	,	,	PUNCT
biomedich-205	443	24	j.	j.	PROPN
biomedich-205	443	25	,	,	PUNCT
biomedich-205	443	26	&	&	CCONJ
biomedich-205	443	27	hegele	hegele	PROPN
biomedich-205	443	28	,	,	PUNCT
biomedich-205	443	29	r.	r.	PROPN
biomedich-205	443	30	a.	a.	PROPN
biomedich-205	443	31	(	(	PUNCT
biomedich-205	443	32	2019	2019	NUM
biomedich-205	443	33	)	)	PUNCT
biomedich-205	443	34	.	.	PUNCT
biomedich-205	444	1	genetic	genetic	ADJ
biomedich-205	444	2	determinants	determinant	NOUN
biomedich-205	444	3	of	of	ADP
biomedich-205	444	4	myocardial	myocardial	ADJ
biomedich-205	444	5	infarction	infarction	NOUN
biomedich-205	444	6	risk	risk	NOUN
biomedich-205	444	7	in	in	ADP
biomedich-205	444	8	familial	familial	ADJ
biomedich-205	444	9	hypercholesterolemia	hypercholesterolemia	NOUN
biomedich-205	444	10	.	.	PUNCT
biomedich-205	445	1	cjc	cjc	PROPN
biomedich-205	445	2	open	open	PROPN
biomedich-205	445	3	,	,	PUNCT
biomedich-205	445	4	1(5	1(5	NUM
biomedich-205	445	5	)	)	PUNCT
biomedich-205	445	6	,	,	PUNCT
biomedich-205	445	7	225–230	225–230	NUM
biomedich-205	445	8	.	.	PUNCT
biomedich-205	446	1	https://doi.org/10.1016/j.cjco.2019.06.001	https://doi.org/10.1016/j.cjco.2019.06.001	VERB
biomedich-205	446	2	this	this	DET
biomedich-205	446	3	page	page	NOUN
biomedich-205	446	4	intentionally	intentionally	ADV
biomedich-205	446	5	left	leave	VERB
biomedich-205	446	6	blank	blank	ADV