id	sid	tid	token	lemma	pos
biomedich-293	1	1	biology	biology	NOUN
biomedich-293	1	2	,	,	PUNCT
biomedich-293	1	3	medicine	medicine	NOUN
biomedich-293	1	4	,	,	PUNCT
biomedich-293	1	5	&	&	CCONJ
biomedich-293	1	6	natural	natural	ADJ
biomedich-293	1	7	product	product	NOUN
biomedich-293	1	8	chemistry	chemistry	NOUN
biomedich-293	1	9	issn	issn	VERB
biomedich-293	1	10	2089	2089	NUM
biomedich-293	1	11	-	-	SYM
biomedich-293	1	12	6514	6514	NUM
biomedich-293	1	13	(	(	PUNCT
biomedich-293	1	14	paper	paper	NOUN
biomedich-293	1	15	)	)	PUNCT
biomedich-293	1	16	volume	volume	NOUN
biomedich-293	1	17	12	12	NUM
biomedich-293	1	18	,	,	PUNCT
biomedich-293	1	19	number	number	NOUN
biomedich-293	1	20	1	1	NUM
biomedich-293	1	21	,	,	PUNCT
biomedich-293	1	22	april	april	PROPN
biomedich-293	1	23	2023	2023	NUM
biomedich-293	2	1	|	|	ADV
biomedich-293	2	2	pages	page	NOUN
biomedich-293	2	3	:	:	PUNCT
biomedich-293	2	4	187	187	NUM
biomedich-293	2	5	-	-	SYM
biomedich-293	2	6	190	190	NUM
biomedich-293	2	7	|	|	ADV
biomedich-293	2	8	doi	doi	NOUN
biomedich-293	2	9	:	:	PUNCT
biomedich-293	2	10	10.14421	10.14421	NUM
biomedich-293	2	11	/	/	SYM
biomedich-293	2	12	biomedich.2023.121.187	biomedich.2023.121.187	PROPN
biomedich-293	2	13	-	-	SYM
biomedich-293	2	14	190	190	NUM
biomedich-293	2	15	issn	issn	PROPN
biomedich-293	2	16	2540	2540	NUM
biomedich-293	2	17	-	-	SYM
biomedich-293	2	18	9328	9328	NUM
biomedich-293	2	19	(	(	PUNCT
biomedich-293	2	20	online	online	ADJ
biomedich-293	2	21	)	)	PUNCT
biomedich-293	2	22	interleukin-1	interleukin-1	NOUN
biomedich-293	2	23	as	as	ADP
biomedich-293	2	24	a	a	DET
biomedich-293	2	25	predictor	predictor	NOUN
biomedich-293	2	26	cytokine	cytokine	NOUN
biomedich-293	2	27	sars	sar	NOUN
biomedich-293	2	28	-	-	PUNCT
biomedich-293	2	29	cov	cov	NOUN
biomedich-293	2	30	:	:	PUNCT
biomedich-293	2	31	article	article	NOUN
biomedich-293	2	32	review	review	VERB
biomedich-293	2	33	lisa	lisa	PROPN
biomedich-293	2	34	savitri	savitri	PROPN
biomedich-293	2	35	*	*	PROPN
biomedich-293	2	36	,	,	PUNCT
biomedich-293	2	37	elfred	elfred	ADJ
biomedich-293	2	38	rinaldo	rinaldo	PROPN
biomedich-293	2	39	kasimo	kasimo	PROPN
biomedich-293	2	40	,	,	PUNCT
biomedich-293	2	41	rochmad	rochmad	ADJ
biomedich-293	2	42	krissanjaya	krissanjaya	NOUN
biomedich-293	2	43	,	,	PUNCT
biomedich-293	2	44	syntia	syntia	PROPN
biomedich-293	2	45	tanu	tanu	PROPN
biomedich-293	2	46	juwita	juwita	PROPN
biomedich-293	2	47	,	,	PUNCT
biomedich-293	2	48	ester	ester	NOUN
biomedich-293	2	49	lianawati	lianawati	PROPN
biomedich-293	2	50	antoro	antoro	PROPN
biomedich-293	2	51	,	,	PUNCT
biomedich-293	2	52	ida	ida	PROPN
biomedich-293	2	53	septika	septika	PROPN
biomedich-293	2	54	wulansari	wulansari	PROPN
biomedich-293	2	55	department	department	PROPN
biomedich-293	2	56	of	of	ADP
biomedich-293	2	57	medical	medical	ADJ
biomedich-293	2	58	laboratory	laboratory	NOUN
biomedich-293	2	59	technology	technology	NOUN
biomedich-293	2	60	,	,	PUNCT
biomedich-293	2	61	faculty	faculty	NOUN
biomedich-293	2	62	of	of	ADP
biomedich-293	2	63	health	health	NOUN
biomedich-293	2	64	sciences	sciences	PROPN
biomedich-293	2	65	,	,	PUNCT
biomedich-293	2	66	kadiri	kadiri	PROPN
biomedich-293	2	67	university	university	PROPN
biomedich-293	2	68	,	,	PUNCT
biomedich-293	2	69	jalan	jalan	PROPN
biomedich-293	2	70	selomangleng	selomangleng	PROPN
biomedich-293	3	1	no	no	INTJ
biomedich-293	3	2	.	.	PROPN
biomedich-293	3	3	1	1	NUM
biomedich-293	3	4	,	,	PUNCT
biomedich-293	3	5	kediri	kediri	PROPN
biomedich-293	3	6	,	,	PUNCT
biomedich-293	3	7	east	east	PROPN
biomedich-293	3	8	java	java	PROPN
biomedich-293	3	9	,	,	PUNCT
biomedich-293	3	10	indonesia	indonesia	PROPN
biomedich-293	3	11	.	.	PUNCT
biomedich-293	4	1	corresponding	correspond	VERB
biomedich-293	4	2	author	author	NOUN
biomedich-293	4	3	*	*	PUNCT
biomedich-293	4	4	lisasavitri@unik-kediri.ac.id	lisasavitri@unik-kediri.ac.id	ADJ
biomedich-293	4	5	manuscript	manuscript	NOUN
biomedich-293	4	6	received	receive	VERB
biomedich-293	4	7	:	:	PUNCT
biomedich-293	4	8	14	14	NUM
biomedich-293	4	9	december	december	NOUN
biomedich-293	4	10	,	,	PUNCT
biomedich-293	4	11	2022	2022	NUM
biomedich-293	4	12	.	.	PUNCT
biomedich-293	5	1	revision	revision	NOUN
biomedich-293	5	2	accepted	accept	VERB
biomedich-293	5	3	:	:	PUNCT
biomedich-293	5	4	07	07	NUM
biomedich-293	5	5	february	february	PROPN
biomedich-293	5	6	,	,	PUNCT
biomedich-293	5	7	2023	2023	NUM
biomedich-293	5	8	.	.	PUNCT
biomedich-293	6	1	published	publish	VERB
biomedich-293	6	2	:	:	PUNCT
biomedich-293	6	3	11	11	NUM
biomedich-293	6	4	february	february	PROPN
biomedich-293	6	5	,	,	PUNCT
biomedich-293	6	6	2023	2023	NUM
biomedich-293	6	7	.	.	PUNCT
biomedich-293	7	1	abstract	abstract	ADJ
biomedich-293	7	2	severe	severe	ADJ
biomedich-293	7	3	acute	acute	ADJ
biomedich-293	7	4	respiratory	respiratory	ADJ
biomedich-293	7	5	syndrome	syndrome	NOUN
biomedich-293	7	6	coronavirus	coronavirus	NOUN
biomedich-293	7	7	(	(	PUNCT
biomedich-293	7	8	sars	sars	PROPN
biomedich-293	7	9	-	-	PUNCT
biomedich-293	7	10	cov	cov	NOUN
biomedich-293	7	11	)	)	PUNCT
biomedich-293	7	12	is	be	AUX
biomedich-293	7	13	an	an	DET
biomedich-293	7	14	etiologic	etiologic	ADJ
biomedich-293	7	15	agent	agent	NOUN
biomedich-293	7	16	of	of	ADP
biomedich-293	7	17	respiratory	respiratory	ADJ
biomedich-293	7	18	disease	disease	NOUN
biomedich-293	7	19	that	that	PRON
biomedich-293	7	20	has	have	VERB
biomedich-293	7	21	a	a	DET
biomedich-293	7	22	mortality	mortality	NOUN
biomedich-293	7	23	rate	rate	NOUN
biomedich-293	7	24	of	of	ADP
biomedich-293	7	25	10	10	NUM
biomedich-293	7	26	%	%	NOUN
biomedich-293	7	27	.	.	PUNCT
biomedich-293	8	1	il-1	il-1	PUNCT
biomedich-293	8	2	actively	actively	ADV
biomedich-293	8	3	participates	participate	VERB
biomedich-293	8	4	in	in	ADP
biomedich-293	8	5	the	the	DET
biomedich-293	8	6	inflammatory	inflammatory	ADJ
biomedich-293	8	7	response	response	NOUN
biomedich-293	8	8	to	to	ADP
biomedich-293	8	9	infection	infection	NOUN
biomedich-293	8	10	.	.	PUNCT
biomedich-293	9	1	sars	sar	NOUN
biomedich-293	9	2	-	-	PUNCT
biomedich-293	9	3	cov-2	cov-2	PART
biomedich-293	9	4	appears	appear	VERB
biomedich-293	9	5	to	to	PART
biomedich-293	9	6	act	act	VERB
biomedich-293	9	7	on	on	ADP
biomedich-293	9	8	the	the	DET
biomedich-293	9	9	activation	activation	NOUN
biomedich-293	9	10	and	and	CCONJ
biomedich-293	9	11	maturation	maturation	NOUN
biomedich-293	9	12	of	of	ADP
biomedich-293	9	13	il1β	il1β	PROPN
biomedich-293	9	14	,	,	PUNCT
biomedich-293	9	15	which	which	PRON
biomedich-293	9	16	in	in	ADP
biomedich-293	9	17	turn	turn	NOUN
biomedich-293	9	18	activates	activate	VERB
biomedich-293	9	19	other	other	ADJ
biomedich-293	9	20	proinflammatory	proinflammatory	ADJ
biomedich-293	9	21	cytokines	cytokine	NOUN
biomedich-293	9	22	,	,	PUNCT
biomedich-293	9	23	such	such	ADJ
biomedich-293	9	24	as	as	ADP
biomedich-293	9	25	il-6	il-6	NUM
biomedich-293	9	26	and	and	CCONJ
biomedich-293	9	27	tnf-	tnf-	X
biomedich-293	9	28	.	.	PUNCT
biomedich-293	10	1	therefore	therefore	ADV
biomedich-293	10	2	,	,	PUNCT
biomedich-293	10	3	il-1β	il-1β	PROPN
biomedich-293	10	4	is	be	AUX
biomedich-293	10	5	part	part	NOUN
biomedich-293	10	6	of	of	ADP
biomedich-293	10	7	the	the	DET
biomedich-293	10	8	cytokine	cytokine	NOUN
biomedich-293	10	9	storm	storm	NOUN
biomedich-293	10	10	generated	generate	VERB
biomedich-293	10	11	by	by	ADP
biomedich-293	10	12	coronavirus	coronavirus	NOUN
biomedich-293	10	13	infection	infection	NOUN
biomedich-293	10	14	.	.	PUNCT
biomedich-293	11	1	elevated	elevated	ADJ
biomedich-293	11	2	levels	level	NOUN
biomedich-293	11	3	of	of	ADP
biomedich-293	11	4	the	the	DET
biomedich-293	11	5	il-1	il-1	NOUN
biomedich-293	11	6	receptor	receptor	NOUN
biomedich-293	11	7	antagonist	antagonist	NOUN
biomedich-293	11	8	(	(	PUNCT
biomedich-293	11	9	il-1ra	il-1ra	NOUN
biomedich-293	11	10	)	)	PUNCT
biomedich-293	11	11	in	in	ADP
biomedich-293	11	12	severe	severe	ADJ
biomedich-293	11	13	cases	case	NOUN
biomedich-293	11	14	of	of	ADP
biomedich-293	11	15	covid-19	covid-19	PROPN
biomedich-293	11	16	,	,	PUNCT
biomedich-293	11	17	and	and	CCONJ
biomedich-293	11	18	this	this	DET
biomedich-293	11	19	marker	marker	NOUN
biomedich-293	11	20	have	have	AUX
biomedich-293	11	21	been	be	AUX
biomedich-293	11	22	associated	associate	VERB
biomedich-293	11	23	with	with	ADP
biomedich-293	11	24	increased	increase	VERB
biomedich-293	11	25	viral	viral	ADJ
biomedich-293	11	26	load	load	NOUN
biomedich-293	11	27	,	,	PUNCT
biomedich-293	11	28	loss	loss	NOUN
biomedich-293	11	29	of	of	ADP
biomedich-293	11	30	lung	lung	NOUN
biomedich-293	11	31	function	function	NOUN
biomedich-293	11	32	,	,	PUNCT
biomedich-293	11	33	lung	lung	NOUN
biomedich-293	11	34	damage	damage	NOUN
biomedich-293	11	35	,	,	PUNCT
biomedich-293	11	36	and	and	CCONJ
biomedich-293	11	37	risk	risk	NOUN
biomedich-293	11	38	of	of	ADP
biomedich-293	11	39	death	death	NOUN
biomedich-293	11	40	.	.	PUNCT
biomedich-293	12	1	in	in	ADP
biomedich-293	12	2	addition	addition	NOUN
biomedich-293	12	3	,	,	PUNCT
biomedich-293	12	4	there	there	PRON
biomedich-293	12	5	is	be	VERB
biomedich-293	12	6	an	an	DET
biomedich-293	12	7	increase	increase	NOUN
biomedich-293	12	8	in	in	ADP
biomedich-293	12	9	il-1α	il-1α	PROPN
biomedich-293	12	10	levels	level	NOUN
biomedich-293	12	11	in	in	ADP
biomedich-293	12	12	patients	patient	NOUN
biomedich-293	12	13	with	with	ADP
biomedich-293	12	14	severe	severe	ADJ
biomedich-293	12	15	covid-19	covid-19	PROPN
biomedich-293	12	16	,	,	PUNCT
biomedich-293	12	17	and	and	CCONJ
biomedich-293	12	18	this	this	PRON
biomedich-293	12	19	is	be	AUX
biomedich-293	12	20	strongly	strongly	ADV
biomedich-293	12	21	associated	associate	VERB
biomedich-293	12	22	with	with	ADP
biomedich-293	12	23	lung	lung	NOUN
biomedich-293	12	24	injury	injury	NOUN
biomedich-293	12	25	.	.	PUNCT
biomedich-293	13	1	il-1	il-1	PUNCT
biomedich-293	13	2	levels	level	NOUN
biomedich-293	13	3	are	be	AUX
biomedich-293	13	4	associated	associate	VERB
biomedich-293	13	5	with	with	ADP
biomedich-293	13	6	the	the	DET
biomedich-293	13	7	virulence	virulence	NOUN
biomedich-293	13	8	of	of	ADP
biomedich-293	13	9	the	the	DET
biomedich-293	13	10	process	process	NOUN
biomedich-293	13	11	,	,	PUNCT
biomedich-293	13	12	and	and	CCONJ
biomedich-293	13	13	significantly	significantly	ADV
biomedich-293	13	14	higher	high	ADJ
biomedich-293	13	15	serum	serum	NOUN
biomedich-293	13	16	levels	level	NOUN
biomedich-293	13	17	have	have	AUX
biomedich-293	13	18	been	be	AUX
biomedich-293	13	19	observed	observe	VERB
biomedich-293	13	20	in	in	ADP
biomedich-293	13	21	severe	severe	ADJ
biomedich-293	13	22	symptomatic	symptomatic	ADJ
biomedich-293	13	23	sars	sar	NOUN
biomedich-293	13	24	-	-	PUNCT
biomedich-293	13	25	cov-2	cov-2	PART
biomedich-293	13	26	cases	case	NOUN
biomedich-293	13	27	than	than	ADP
biomedich-293	13	28	in	in	ADP
biomedich-293	13	29	mild	mild	ADJ
biomedich-293	13	30	cases	case	NOUN
biomedich-293	13	31	or	or	CCONJ
biomedich-293	13	32	in	in	ADP
biomedich-293	13	33	those	those	PRON
biomedich-293	13	34	infected	infect	VERB
biomedich-293	13	35	with	with	ADP
biomedich-293	13	36	the	the	DET
biomedich-293	13	37	2003	2003	NUM
biomedich-293	13	38	sars	sar	NOUN
biomedich-293	13	39	-	-	PUNCT
biomedich-293	13	40	cov	cov	NOUN
biomedich-293	13	41	coronavirus	coronavirus	NOUN
biomedich-293	13	42	or	or	CCONJ
biomedich-293	13	43	2012	2012	NUM
biomedich-293	13	44	mers	mer	NOUN
biomedich-293	13	45	coronavirus	coronavirus	NOUN
biomedich-293	13	46	.	.	PUNCT
biomedich-293	14	1	keywords	keyword	NOUN
biomedich-293	14	2	:	:	PUNCT
biomedich-293	14	3	cytokines	cytokine	NOUN
biomedich-293	14	4	;	;	PUNCT
biomedich-293	14	5	interleukin-1	interleukin-1	NUM
biomedich-293	14	6	;	;	PUNCT
biomedich-293	14	7	severe	severe	ADJ
biomedich-293	14	8	acute	acute	ADJ
biomedich-293	14	9	respiratory	respiratory	ADJ
biomedich-293	14	10	syndrome	syndrome	NOUN
biomedich-293	14	11	coronavirus	coronavirus	NOUN
biomedich-293	14	12	(	(	PUNCT
biomedich-293	14	13	sars	sars	PROPN
biomedich-293	14	14	-	-	PUNCT
biomedich-293	14	15	cov	cov	NOUN
biomedich-293	14	16	)	)	PUNCT
biomedich-293	14	17	.	.	PUNCT
biomedich-293	15	1	abbreviations	abbreviation	NOUN
biomedich-293	15	2	:	:	PUNCT
biomedich-293	15	3	severe	severe	ADJ
biomedich-293	15	4	acute	acute	ADJ
biomedich-293	15	5	respiratory	respiratory	ADJ
biomedich-293	15	6	syndrome	syndrome	NOUN
biomedich-293	15	7	coronavirus	coronavirus	NOUN
biomedich-293	15	8	(	(	PUNCT
biomedich-293	15	9	sars	sars	PROPN
biomedich-293	15	10	-	-	PUNCT
biomedich-293	15	11	cov	cov	NOUN
biomedich-293	15	12	)	)	PUNCT
biomedich-293	15	13	,	,	PUNCT
biomedich-293	15	14	il-1	il-1	ADP
biomedich-293	15	15	receptor	receptor	NOUN
biomedich-293	15	16	antagonist	antagonist	NOUN
biomedich-293	15	17	(	(	PUNCT
biomedich-293	15	18	il-1ra	il-1ra	NOUN
biomedich-293	15	19	)	)	PUNCT
biomedich-293	15	20	,	,	PUNCT
biomedich-293	15	21	interleukin-1	interleukin-1	NUM
biomedich-293	15	22	(	(	PUNCT
biomedich-293	15	23	il-1	il-1	NUM
biomedich-293	15	24	)	)	PUNCT
biomedich-293	15	25	,	,	PUNCT
biomedich-293	15	26	sars	sars	PROPN
biomedich-293	15	27	-	-	PUNCT
biomedich-293	15	28	cov	cov	NOUN
biomedich-293	15	29	lacking	lack	VERB
biomedich-293	15	30	the	the	DET
biomedich-293	15	31	e	e	NOUN
biomedich-293	15	32	gene	gene	NOUN
biomedich-293	15	33	(	(	PUNCT
biomedich-293	15	34	sars	sars	NOUN
biomedich-293	15	35	-	-	PUNCT
biomedich-293	15	36	cov	cov	NOUN
biomedich-293	15	37	-	-	PUNCT
biomedich-293	15	38	δe	δe	NOUN
biomedich-293	15	39	)	)	PUNCT
biomedich-293	15	40	,	,	PUNCT
biomedich-293	15	41	open	open	ADJ
biomedich-293	15	42	reading	reading	NOUN
biomedich-293	15	43	frame	frame	NOUN
biomedich-293	15	44	3a	3a	NUM
biomedich-293	15	45	(	(	PUNCT
biomedich-293	15	46	orf3a	orf3a	PROPN
biomedich-293	15	47	)	)	PUNCT
biomedich-293	15	48	,	,	PUNCT
biomedich-293	15	49	tnf	tnf	PROPN
biomedich-293	15	50	receptor	receptor	NOUN
biomedich-293	15	51	-	-	PUNCT
biomedich-293	15	52	associated	associate	VERB
biomedich-293	15	53	factor	factor	NOUN
biomedich-293	15	54	3	3	NUM
biomedich-293	15	55	(	(	PUNCT
biomedich-293	15	56	traf3	traf3	NOUN
biomedich-293	15	57	)	)	PUNCT
biomedich-293	15	58	,	,	PUNCT
biomedich-293	15	59	recruitment	recruitment	NOUN
biomedich-293	15	60	caspase	caspase	NOUN
biomedich-293	15	61	domain	domain	NOUN
biomedich-293	15	62	(	(	PUNCT
biomedich-293	15	63	asc	asc	PROPN
biomedich-293	15	64	)	)	PUNCT
biomedich-293	15	65	interleukin-1	interleukin-1	NUM
biomedich-293	15	66	and	and	CCONJ
biomedich-293	15	67	infection	infection	NOUN
biomedich-293	15	68	the	the	DET
biomedich-293	15	69	interleukin-1	interleukin-1	NUM
biomedich-293	15	70	(	(	PUNCT
biomedich-293	15	71	il-1	il-1	NUM
biomedich-293	15	72	)	)	PUNCT
biomedich-293	15	73	family	family	NOUN
biomedich-293	15	74	of	of	ADP
biomedich-293	15	75	ligands	ligand	NOUN
biomedich-293	15	76	and	and	CCONJ
biomedich-293	15	77	receptors	receptor	NOUN
biomedich-293	15	78	plays	play	VERB
biomedich-293	15	79	a	a	DET
biomedich-293	15	80	central	central	ADJ
biomedich-293	15	81	role	role	NOUN
biomedich-293	15	82	in	in	ADP
biomedich-293	15	83	the	the	DET
biomedich-293	15	84	formation	formation	NOUN
biomedich-293	15	85	and	and	CCONJ
biomedich-293	15	86	regulation	regulation	NOUN
biomedich-293	15	87	of	of	ADP
biomedich-293	15	88	inflammation	inflammation	NOUN
biomedich-293	15	89	as	as	ADP
biomedich-293	15	90	part	part	NOUN
biomedich-293	15	91	of	of	ADP
biomedich-293	15	92	the	the	DET
biomedich-293	15	93	immune	immune	ADJ
biomedich-293	15	94	response	response	NOUN
biomedich-293	15	95	.	.	PUNCT
biomedich-293	16	1	the	the	DET
biomedich-293	16	2	il-1	il-1	ADP
biomedich-293	16	3	molecule	molecule	NOUN
biomedich-293	16	4	is	be	AUX
biomedich-293	16	5	best	well	ADV
biomedich-293	16	6	known	know	VERB
biomedich-293	16	7	as	as	ADP
biomedich-293	16	8	a	a	DET
biomedich-293	16	9	member	member	NOUN
biomedich-293	16	10	of	of	ADP
biomedich-293	16	11	a	a	DET
biomedich-293	16	12	family	family	NOUN
biomedich-293	16	13	of	of	ADP
biomedich-293	16	14	proinflammatory	proinflammatory	ADJ
biomedich-293	16	15	proteins	protein	NOUN
biomedich-293	16	16	called	call	VERB
biomedich-293	16	17	cytokines	cytokine	NOUN
biomedich-293	16	18	.	.	PUNCT
biomedich-293	17	1	they	they	PRON
biomedich-293	17	2	have	have	AUX
biomedich-293	17	3	been	be	AUX
biomedich-293	17	4	shown	show	VERB
biomedich-293	17	5	to	to	PART
biomedich-293	17	6	play	play	VERB
biomedich-293	17	7	a	a	DET
biomedich-293	17	8	role	role	NOUN
biomedich-293	17	9	,	,	PUNCT
biomedich-293	17	10	not	not	PART
biomedich-293	17	11	only	only	ADV
biomedich-293	17	12	during	during	ADP
biomedich-293	17	13	inflammation	inflammation	NOUN
biomedich-293	17	14	,	,	PUNCT
biomedich-293	17	15	but	but	CCONJ
biomedich-293	17	16	also	also	ADV
biomedich-293	17	17	in	in	ADP
biomedich-293	17	18	influencing	influence	VERB
biomedich-293	17	19	additional	additional	ADJ
biomedich-293	17	20	physiological	physiological	ADJ
biomedich-293	17	21	and	and	CCONJ
biomedich-293	17	22	pathological	pathological	ADJ
biomedich-293	17	23	functions	function	NOUN
biomedich-293	17	24	such	such	ADJ
biomedich-293	17	25	as	as	ADP
biomedich-293	17	26	autoimmune	autoimmune	ADJ
biomedich-293	17	27	diseases	disease	NOUN
biomedich-293	17	28	,	,	PUNCT
biomedich-293	17	29	malignancies	malignancy	NOUN
biomedich-293	17	30	,	,	PUNCT
biomedich-293	17	31	and	and	CCONJ
biomedich-293	17	32	many	many	ADJ
biomedich-293	17	33	others	other	NOUN
biomedich-293	17	34	.	.	PUNCT
biomedich-293	18	1	in	in	ADP
biomedich-293	18	2	addition	addition	NOUN
biomedich-293	18	3	,	,	PUNCT
biomedich-293	18	4	the	the	DET
biomedich-293	18	5	biological	biological	ADJ
biomedich-293	18	6	balance	balance	NOUN
biomedich-293	18	7	between	between	ADP
biomedich-293	18	8	proinflammatory	proinflammatory	ADJ
biomedich-293	18	9	and	and	CCONJ
biomedich-293	18	10	inhibitory	inhibitory	ADJ
biomedich-293	18	11	activity	activity	NOUN
biomedich-293	18	12	is	be	AUX
biomedich-293	18	13	critical	critical	ADJ
biomedich-293	18	14	,	,	PUNCT
biomedich-293	18	15	as	as	SCONJ
biomedich-293	18	16	any	any	DET
biomedich-293	18	17	change	change	NOUN
biomedich-293	18	18	in	in	ADP
biomedich-293	18	19	the	the	DET
biomedich-293	18	20	expression	expression	NOUN
biomedich-293	18	21	of	of	ADP
biomedich-293	18	22	the	the	DET
biomedich-293	18	23	il-1	il-1	PUNCT
biomedich-293	18	24	family	family	NOUN
biomedich-293	18	25	has	have	VERB
biomedich-293	18	26	the	the	DET
biomedich-293	18	27	potential	potential	NOUN
biomedich-293	18	28	to	to	PART
biomedich-293	18	29	cause	cause	VERB
biomedich-293	18	30	disease	disease	NOUN
biomedich-293	18	31	(	(	PUNCT
biomedich-293	18	32	etti	etti	PROPN
biomedich-293	18	33	,	,	PUNCT
biomedich-293	18	34	et	et	PROPN
biomedich-293	18	35	al	al	PROPN
biomedich-293	18	36	.	.	PROPN
biomedich-293	18	37	,	,	PUNCT
biomedich-293	18	38	2018	2018	NUM
biomedich-293	18	39	)	)	PUNCT
biomedich-293	18	40	.	.	PUNCT
biomedich-293	19	1	inflammation	inflammation	NOUN
biomedich-293	19	2	that	that	PRON
biomedich-293	19	3	occurs	occur	VERB
biomedich-293	19	4	as	as	ADP
biomedich-293	19	5	a	a	DET
biomedich-293	19	6	result	result	NOUN
biomedich-293	19	7	of	of	ADP
biomedich-293	19	8	exposure	exposure	NOUN
biomedich-293	19	9	of	of	ADP
biomedich-293	19	10	tissues	tissue	NOUN
biomedich-293	19	11	and	and	CCONJ
biomedich-293	19	12	organs	organ	NOUN
biomedich-293	19	13	to	to	ADP
biomedich-293	19	14	noxious	noxious	ADJ
biomedich-293	19	15	stimuli	stimulus	NOUN
biomedich-293	19	16	such	such	ADJ
biomedich-293	19	17	as	as	ADP
biomedich-293	19	18	microbial	microbial	ADJ
biomedich-293	19	19	pathogens	pathogen	NOUN
biomedich-293	19	20	,	,	PUNCT
biomedich-293	19	21	irritants	irritant	NOUN
biomedich-293	19	22	,	,	PUNCT
biomedich-293	19	23	or	or	CCONJ
biomedich-293	19	24	toxic	toxic	ADJ
biomedich-293	19	25	cellular	cellular	ADJ
biomedich-293	19	26	components	component	NOUN
biomedich-293	19	27	.	.	PUNCT
biomedich-293	20	1	the	the	DET
biomedich-293	20	2	main	main	ADJ
biomedich-293	20	3	physical	physical	ADJ
biomedich-293	20	4	manifestations	manifestation	NOUN
biomedich-293	20	5	of	of	ADP
biomedich-293	20	6	inflammation	inflammation	NOUN
biomedich-293	20	7	are	be	AUX
biomedich-293	20	8	redness	redness	NOUN
biomedich-293	20	9	,	,	PUNCT
biomedich-293	20	10	swelling	swelling	NOUN
biomedich-293	20	11	,	,	PUNCT
biomedich-293	20	12	heat	heat	NOUN
biomedich-293	20	13	,	,	PUNCT
biomedich-293	20	14	pain	pain	NOUN
biomedich-293	20	15	,	,	PUNCT
biomedich-293	20	16	and	and	CCONJ
biomedich-293	20	17	loss	loss	NOUN
biomedich-293	20	18	of	of	ADP
biomedich-293	20	19	function	function	NOUN
biomedich-293	20	20	in	in	ADP
biomedich-293	20	21	the	the	DET
biomedich-293	20	22	affected	affected	ADJ
biomedich-293	20	23	area	area	NOUN
biomedich-293	20	24	.	.	PUNCT
biomedich-293	21	1	this	this	DET
biomedich-293	21	2	process	process	NOUN
biomedich-293	21	3	involves	involve	VERB
biomedich-293	21	4	the	the	DET
biomedich-293	21	5	main	main	ADJ
biomedich-293	21	6	cells	cell	NOUN
biomedich-293	21	7	of	of	ADP
biomedich-293	21	8	the	the	DET
biomedich-293	21	9	immune	immune	ADJ
biomedich-293	21	10	system	system	NOUN
biomedich-293	21	11	,	,	PUNCT
biomedich-293	21	12	including	include	VERB
biomedich-293	21	13	monocytes	monocyte	NOUN
biomedich-293	21	14	,	,	PUNCT
biomedich-293	21	15	macrophages	macrophage	NOUN
biomedich-293	21	16	,	,	PUNCT
biomedich-293	21	17	neutrophils	neutrophil	NOUN
biomedich-293	21	18	,	,	PUNCT
biomedich-293	21	19	basophils	basophil	NOUN
biomedich-293	21	20	,	,	PUNCT
biomedich-293	21	21	dendritic	dendritic	ADJ
biomedich-293	21	22	cells	cell	NOUN
biomedich-293	21	23	,	,	PUNCT
biomedich-293	21	24	mast	mast	NOUN
biomedich-293	21	25	cells	cell	NOUN
biomedich-293	21	26	,	,	PUNCT
biomedich-293	21	27	t	t	NOUN
biomedich-293	21	28	cells	cell	NOUN
biomedich-293	21	29	,	,	PUNCT
biomedich-293	21	30	and	and	CCONJ
biomedich-293	21	31	b	b	X
biomedich-293	21	32	cells	cell	NOUN
biomedich-293	21	33	.	.	PUNCT
biomedich-293	22	1	however	however	ADV
biomedich-293	22	2	,	,	PUNCT
biomedich-293	22	3	examination	examination	NOUN
biomedich-293	22	4	of	of	ADP
biomedich-293	22	5	various	various	ADJ
biomedich-293	22	6	inflammatory	inflammatory	ADJ
biomedich-293	22	7	lesions	lesion	NOUN
biomedich-293	22	8	reveals	reveal	VERB
biomedich-293	22	9	the	the	DET
biomedich-293	22	10	presence	presence	NOUN
biomedich-293	22	11	of	of	ADP
biomedich-293	22	12	specific	specific	ADJ
biomedich-293	22	13	leukocytes	leukocyte	NOUN
biomedich-293	22	14	in	in	ADP
biomedich-293	22	15	certain	certain	ADJ
biomedich-293	22	16	lesions	lesion	NOUN
biomedich-293	22	17	.	.	PUNCT
biomedich-293	23	1	that	that	PRON
biomedich-293	23	2	is	is	ADV
biomedich-293	23	3	,	,	PUNCT
biomedich-293	23	4	the	the	DET
biomedich-293	23	5	inflammatory	inflammatory	ADJ
biomedich-293	23	6	process	process	NOUN
biomedich-293	23	7	is	be	AUX
biomedich-293	23	8	regulated	regulate	VERB
biomedich-293	23	9	in	in	ADP
biomedich-293	23	10	such	such	DET
biomedich-293	23	11	a	a	DET
biomedich-293	23	12	way	way	NOUN
biomedich-293	23	13	as	as	SCONJ
biomedich-293	23	14	to	to	PART
biomedich-293	23	15	ensure	ensure	VERB
biomedich-293	23	16	that	that	SCONJ
biomedich-293	23	17	the	the	DET
biomedich-293	23	18	right	right	ADJ
biomedich-293	23	19	leukocytes	leukocyte	NOUN
biomedich-293	23	20	are	be	AUX
biomedich-293	23	21	recruited	recruit	VERB
biomedich-293	23	22	.	.	PUNCT
biomedich-293	24	1	these	these	DET
biomedich-293	24	2	events	event	NOUN
biomedich-293	24	3	are	be	AUX
biomedich-293	24	4	in	in	ADP
biomedich-293	24	5	turn	turn	NOUN
biomedich-293	24	6	controlled	control	VERB
biomedich-293	24	7	by	by	ADP
biomedich-293	24	8	a	a	DET
biomedich-293	24	9	number	number	NOUN
biomedich-293	24	10	of	of	ADP
biomedich-293	24	11	extracellular	extracellular	ADJ
biomedich-293	24	12	molecular	molecular	ADJ
biomedich-293	24	13	regulators	regulator	NOUN
biomedich-293	24	14	,	,	PUNCT
biomedich-293	24	15	including	include	VERB
biomedich-293	24	16	members	member	NOUN
biomedich-293	24	17	of	of	ADP
biomedich-293	24	18	the	the	DET
biomedich-293	24	19	cytokine	cytokine	NOUN
biomedich-293	24	20	and	and	CCONJ
biomedich-293	24	21	chemokine	chemokine	ADJ
biomedich-293	24	22	family	family	NOUN
biomedich-293	24	23	that	that	PRON
biomedich-293	24	24	mediate	mediate	VERB
biomedich-293	24	25	immune	immune	ADJ
biomedich-293	24	26	cell	cell	NOUN
biomedich-293	24	27	recruitment	recruitment	NOUN
biomedich-293	24	28	and	and	CCONJ
biomedich-293	24	29	the	the	DET
biomedich-293	24	30	complex	complex	ADJ
biomedich-293	24	31	intracellular	intracellular	ADJ
biomedich-293	24	32	signaling	signal	VERB
biomedich-293	24	33	control	control	NOUN
biomedich-293	24	34	mechanisms	mechanism	NOUN
biomedich-293	24	35	that	that	PRON
biomedich-293	24	36	characterize	characterize	VERB
biomedich-293	24	37	inflammation	inflammation	NOUN
biomedich-293	24	38	.	.	PUNCT
biomedich-293	25	1	this	this	DET
biomedich-293	25	2	review	review	NOUN
biomedich-293	25	3	will	will	AUX
biomedich-293	25	4	focus	focus	VERB
biomedich-293	25	5	on	on	ADP
biomedich-293	25	6	the	the	DET
biomedich-293	25	7	role	role	NOUN
biomedich-293	25	8	of	of	ADP
biomedich-293	25	9	major	major	ADJ
biomedich-293	25	10	cytokines	cytokine	NOUN
biomedich-293	25	11	,	,	PUNCT
biomedich-293	25	12	chemokines	chemokine	NOUN
biomedich-293	25	13	,	,	PUNCT
biomedich-293	25	14	and	and	CCONJ
biomedich-293	25	15	their	their	PRON
biomedich-293	25	16	receptors	receptor	NOUN
biomedich-293	25	17	in	in	ADP
biomedich-293	25	18	the	the	DET
biomedich-293	25	19	pathophysiology	pathophysiology	NOUN
biomedich-293	25	20	of	of	ADP
biomedich-293	25	21	autoinflammatory	autoinflammatory	NOUN
biomedich-293	25	22	disorders	disorder	NOUN
biomedich-293	25	23	,	,	PUNCT
biomedich-293	25	24	pro	pro	ADJ
biomedich-293	25	25	-	-	ADJ
biomedich-293	25	26	inflammatory	inflammatory	ADJ
biomedich-293	25	27	disorders	disorder	NOUN
biomedich-293	25	28	,	,	PUNCT
biomedich-293	25	29	and	and	CCONJ
biomedich-293	25	30	neurologic	neurologic	ADJ
biomedich-293	25	31	disorders	disorder	NOUN
biomedich-293	25	32	involving	involve	VERB
biomedich-293	25	33	inflammation	inflammation	NOUN
biomedich-293	25	34	.	.	PUNCT
biomedich-293	26	1	il-1	il-1	PUNCT
biomedich-293	26	2	actively	actively	ADV
biomedich-293	26	3	participates	participate	VERB
biomedich-293	26	4	in	in	ADP
biomedich-293	26	5	the	the	DET
biomedich-293	26	6	inflammatory	inflammatory	ADJ
biomedich-293	26	7	response	response	NOUN
biomedich-293	26	8	to	to	ADP
biomedich-293	26	9	infection	infection	NOUN
biomedich-293	26	10	(	(	PUNCT
biomedich-293	26	11	turner	turner	PROPN
biomedich-293	26	12	,	,	PUNCT
biomedich-293	26	13	et	et	PROPN
biomedich-293	26	14	al	al	PROPN
biomedich-293	26	15	.	.	PROPN
biomedich-293	26	16	,	,	PUNCT
biomedich-293	26	17	2014	2014	NUM
biomedich-293	26	18	)	)	PUNCT
biomedich-293	26	19	,	,	PUNCT
biomedich-293	26	20	and	and	CCONJ
biomedich-293	26	21	its	its	PRON
biomedich-293	26	22	main	main	ADJ
biomedich-293	26	23	source	source	NOUN
biomedich-293	26	24	is	be	AUX
biomedich-293	26	25	activated	activate	VERB
biomedich-293	26	26	monocytes	monocyte	NOUN
biomedich-293	26	27	and	and	CCONJ
biomedich-293	26	28	macrophages	macrophage	NOUN
biomedich-293	26	29	.	.	PUNCT
biomedich-293	27	1	interleukin-1	interleukin-1	NOUN
biomedich-293	27	2	as	as	ADP
biomedich-293	27	3	a	a	DET
biomedich-293	27	4	predictor	predictor	NOUN
biomedich-293	27	5	cytokine	cytokine	NOUN
biomedich-293	27	6	sars	sar	NOUN
biomedich-293	27	7	-	-	PUNCT
biomedich-293	27	8	cov	cov	NOUN
biomedich-293	27	9	severe	severe	ADJ
biomedich-293	27	10	acute	acute	ADJ
biomedich-293	27	11	respiratory	respiratory	ADJ
biomedich-293	27	12	syndrome	syndrome	NOUN
biomedich-293	27	13	coronavirus	coronavirus	NOUN
biomedich-293	27	14	(	(	PUNCT
biomedich-293	27	15	sarscov	sarscov	PROPN
biomedich-293	27	16	)	)	PUNCT
biomedich-293	27	17	is	be	AUX
biomedich-293	27	18	the	the	DET
biomedich-293	27	19	etiologic	etiologic	ADJ
biomedich-293	27	20	agent	agent	NOUN
biomedich-293	27	21	of	of	ADP
biomedich-293	27	22	respiratory	respiratory	ADJ
biomedich-293	27	23	disease	disease	NOUN
biomedich-293	27	24	that	that	PRON
biomedich-293	27	25	has	have	VERB
biomedich-293	27	26	a	a	DET
biomedich-293	27	27	mortality	mortality	NOUN
biomedich-293	27	28	rate	rate	NOUN
biomedich-293	27	29	of	of	ADP
biomedich-293	27	30	10	10	NUM
biomedich-293	27	31	%	%	NOUN
biomedich-293	27	32	.	.	PUNCT
biomedich-293	28	1	previous	previous	ADJ
biomedich-293	28	2	studies	study	NOUN
biomedich-293	28	3	have	have	AUX
biomedich-293	28	4	shown	show	VERB
biomedich-293	28	5	that	that	SCONJ
biomedich-293	28	6	sars	sar	NOUN
biomedich-293	28	7	-	-	PUNCT
biomedich-293	28	8	cov	cov	NOUN
biomedich-293	28	9	lacking	lack	VERB
biomedich-293	28	10	the	the	DET
biomedich-293	28	11	e	e	NOUN
biomedich-293	28	12	gene	gene	NOUN
biomedich-293	28	13	(	(	PUNCT
biomedich-293	28	14	sars	sars	NOUN
biomedich-293	28	15	-	-	PUNCT
biomedich-293	28	16	cov	cov	NOUN
biomedich-293	28	17	-	-	PUNCT
biomedich-293	28	18	δe	δe	NOUN
biomedich-293	28	19	)	)	PUNCT
biomedich-293	28	20	is	be	AUX
biomedich-293	28	21	attenuated	attenuate	VERB
biomedich-293	28	22	in	in	ADP
biomedich-293	28	23	several	several	ADJ
biomedich-293	28	24	animal	animal	NOUN
biomedich-293	28	25	model	model	NOUN
biomedich-293	28	26	systems	system	NOUN
biomedich-293	28	27	.	.	PUNCT
biomedich-293	29	1	this	this	DET
biomedich-293	29	2	https://doi.org/10.14421/biomedich.2023.121.187-190	https://doi.org/10.14421/biomedich.2023.121.187-190	PUNCT
biomedich-293	29	3	188	188	NUM
biomedich-293	29	4	biology	biology	NOUN
biomedich-293	29	5	,	,	PUNCT
biomedich-293	29	6	medicine	medicine	NOUN
biomedich-293	29	7	,	,	PUNCT
biomedich-293	29	8	&	&	CCONJ
biomedich-293	29	9	natural	natural	ADJ
biomedich-293	29	10	product	product	NOUN
biomedich-293	29	11	chemistry	chemistry	NOUN
biomedich-293	29	12	12	12	NUM
biomedich-293	29	13	(	(	PUNCT
biomedich-293	29	14	1	1	NUM
biomedich-293	29	15	)	)	PUNCT
biomedich-293	29	16	,	,	PUNCT
biomedich-293	29	17	2023	2023	NUM
biomedich-293	29	18	:	:	PUNCT
biomedich-293	29	19	187	187	NUM
biomedich-293	29	20	-	-	SYM
biomedich-293	29	21	190	190	NUM
biomedich-293	29	22	suggests	suggest	VERB
biomedich-293	29	23	that	that	SCONJ
biomedich-293	29	24	the	the	DET
biomedich-293	29	25	absence	absence	NOUN
biomedich-293	29	26	of	of	ADP
biomedich-293	29	27	protein	protein	NOUN
biomedich-293	29	28	e	e	NOUN
biomedich-293	29	29	resulted	result	VERB
biomedich-293	29	30	in	in	ADP
biomedich-293	29	31	reduced	reduced	ADJ
biomedich-293	29	32	expression	expression	NOUN
biomedich-293	29	33	of	of	ADP
biomedich-293	29	34	proinflammatory	proinflammatory	ADJ
biomedich-293	29	35	cytokines	cytokine	NOUN
biomedich-293	29	36	,	,	PUNCT
biomedich-293	29	37	decreased	decrease	VERB
biomedich-293	29	38	number	number	NOUN
biomedich-293	29	39	of	of	ADP
biomedich-293	29	40	neutrophils	neutrophil	NOUN
biomedich-293	29	41	in	in	ADP
biomedich-293	29	42	the	the	DET
biomedich-293	29	43	lung	lung	NOUN
biomedich-293	29	44	infiltrates	infiltrate	NOUN
biomedich-293	29	45	,	,	PUNCT
biomedich-293	29	46	reduced	reduce	VERB
biomedich-293	29	47	lung	lung	NOUN
biomedich-293	29	48	pathology	pathology	NOUN
biomedich-293	29	49	,	,	PUNCT
biomedich-293	29	50	and	and	CCONJ
biomedich-293	29	51	increased	increase	VERB
biomedich-293	29	52	viability	viability	NOUN
biomedich-293	29	53	of	of	ADP
biomedich-293	29	54	mice	mouse	NOUN
biomedich-293	29	55	,	,	PUNCT
biomedich-293	29	56	suggesting	suggest	VERB
biomedich-293	29	57	that	that	SCONJ
biomedich-293	29	58	lung	lung	NOUN
biomedich-293	29	59	inflammation	inflammation	NOUN
biomedich-293	29	60	contributes	contribute	VERB
biomedich-293	29	61	to	to	PART
biomedich-293	29	62	sarscov	sarscov	VERB
biomedich-293	29	63	virulence	virulence	NOUN
biomedich-293	29	64	.	.	PUNCT
biomedich-293	30	1	furthermore	furthermore	ADV
biomedich-293	30	2	,	,	PUNCT
biomedich-293	30	3	sars	sars	PROPN
biomedich-293	30	4	-	-	PUNCT
biomedich-293	30	5	cov	cov	NOUN
biomedich-293	30	6	-	-	PUNCT
biomedich-293	30	7	δe	δe	NOUN
biomedich-293	30	8	infection	infection	NOUN
biomedich-293	30	9	resulted	result	VERB
biomedich-293	30	10	in	in	ADP
biomedich-293	30	11	decreased	decrease	VERB
biomedich-293	30	12	nf	nf	ADJ
biomedich-293	30	13	-	-	PUNCT
biomedich-293	30	14	b	b	NOUN
biomedich-293	30	15	activation	activation	NOUN
biomedich-293	30	16	compared	compare	VERB
biomedich-293	30	17	to	to	ADP
biomedich-293	30	18	levels	level	NOUN
biomedich-293	30	19	of	of	ADP
biomedich-293	30	20	wild	wild	ADJ
biomedich-293	30	21	-	-	PUNCT
biomedich-293	30	22	type	type	NOUN
biomedich-293	30	23	virus	virus	NOUN
biomedich-293	30	24	.	.	PUNCT
biomedich-293	31	1	most	most	ADV
biomedich-293	31	2	importantly	importantly	ADV
biomedich-293	31	3	,	,	PUNCT
biomedich-293	31	4	treatment	treatment	NOUN
biomedich-293	31	5	with	with	ADP
biomedich-293	31	6	drugs	drug	NOUN
biomedich-293	31	7	that	that	PRON
biomedich-293	31	8	inhibit	inhibit	VERB
biomedich-293	31	9	nf	nf	ADJ
biomedich-293	31	10	-	-	PUNCT
biomedich-293	31	11	kb	kb	NOUN
biomedich-293	31	12	activation	activation	NOUN
biomedich-293	31	13	led	lead	VERB
biomedich-293	31	14	to	to	ADP
biomedich-293	31	15	a	a	DET
biomedich-293	31	16	reduction	reduction	NOUN
biomedich-293	31	17	in	in	ADP
biomedich-293	31	18	inflammation	inflammation	NOUN
biomedich-293	31	19	and	and	CCONJ
biomedich-293	31	20	lung	lung	NOUN
biomedich-293	31	21	pathology	pathology	NOUN
biomedich-293	31	22	in	in	ADP
biomedich-293	31	23	sars	sars	PROPN
biomedich-293	31	24	-	-	PUNCT
biomedich-293	31	25	cov	cov	NOUN
biomedich-293	31	26	-	-	PUNCT
biomedich-293	31	27	infected	infect	VERB
biomedich-293	31	28	cells	cell	NOUN
biomedich-293	31	29	and	and	CCONJ
biomedich-293	31	30	mice	mouse	NOUN
biomedich-293	31	31	and	and	CCONJ
biomedich-293	31	32	significantly	significantly	ADV
biomedich-293	31	33	improved	improve	VERB
biomedich-293	31	34	mouse	mouse	NOUN
biomedich-293	31	35	survival	survival	NOUN
biomedich-293	31	36	after	after	ADP
biomedich-293	31	37	sars	sars	PROPN
biomedich-293	31	38	-	-	PUNCT
biomedich-293	31	39	cov	cov	NOUN
biomedich-293	31	40	infection	infection	NOUN
biomedich-293	31	41	.	.	PUNCT
biomedich-293	32	1	these	these	DET
biomedich-293	32	2	data	datum	NOUN
biomedich-293	32	3	suggest	suggest	VERB
biomedich-293	32	4	that	that	SCONJ
biomedich-293	32	5	activation	activation	NOUN
biomedich-293	32	6	of	of	ADP
biomedich-293	32	7	the	the	DET
biomedich-293	32	8	nf	nf	NOUN
biomedich-293	32	9	-	-	PUNCT
biomedich-293	32	10	b	b	NOUN
biomedich-293	32	11	signaling	signal	VERB
biomedich-293	32	12	pathway	pathway	NOUN
biomedich-293	32	13	represents	represent	VERB
biomedich-293	32	14	a	a	DET
biomedich-293	32	15	major	major	ADJ
biomedich-293	32	16	contribution	contribution	NOUN
biomedich-293	32	17	to	to	ADP
biomedich-293	32	18	inflammation	inflammation	NOUN
biomedich-293	32	19	induced	induce	VERB
biomedich-293	32	20	after	after	ADP
biomedich-293	32	21	sarscov	sarscov	NOUN
biomedich-293	32	22	infection	infection	NOUN
biomedich-293	32	23	and	and	CCONJ
biomedich-293	32	24	that	that	SCONJ
biomedich-293	32	25	nf	nf	ADJ
biomedich-293	32	26	-	-	PUNCT
biomedich-293	32	27	b	b	NOUN
biomedich-293	32	28	inhibitors	inhibitor	NOUN
biomedich-293	32	29	hold	hold	VERB
biomedich-293	32	30	antiviral	antiviral	ADJ
biomedich-293	32	31	promise	promise	NOUN
biomedich-293	32	32	in	in	ADP
biomedich-293	32	33	infections	infection	NOUN
biomedich-293	32	34	caused	cause	VERB
biomedich-293	32	35	by	by	ADP
biomedich-293	32	36	sars	sar	NOUN
biomedich-293	32	37	-	-	PUNCT
biomedich-293	32	38	cov	cov	PROPN
biomedich-293	32	39	and	and	CCONJ
biomedich-293	32	40	other	other	ADJ
biomedich-293	32	41	potentially	potentially	ADV
biomedich-293	32	42	pathogenic	pathogenic	ADJ
biomedich-293	32	43	human	human	ADJ
biomedich-293	32	44	coronaviruses	coronaviruse	NOUN
biomedich-293	32	45	(	(	PUNCT
biomedich-293	32	46	dediego	dediego	NOUN
biomedich-293	32	47	,	,	PUNCT
biomedich-293	32	48	et	et	PROPN
biomedich-293	32	49	al	al	PROPN
biomedich-293	32	50	.	.	PROPN
biomedich-293	32	51	,	,	PUNCT
biomedich-293	32	52	2014	2014	NUM
biomedich-293	32	53	)	)	PUNCT
biomedich-293	32	54	.	.	PUNCT
biomedich-293	33	1	deletion	deletion	NOUN
biomedich-293	33	2	of	of	ADP
biomedich-293	33	3	the	the	DET
biomedich-293	33	4	sars	sar	NOUN
biomedich-293	33	5	-	-	PUNCT
biomedich-293	33	6	cov	cov	NOUN
biomedich-293	33	7	envelope	envelope	NOUN
biomedich-293	33	8	(	(	PUNCT
biomedich-293	33	9	e	e	NOUN
biomedich-293	33	10	)	)	PUNCT
biomedich-293	33	11	gene	gene	NOUN
biomedich-293	33	12	attenuates	attenuate	VERB
biomedich-293	33	13	the	the	DET
biomedich-293	33	14	virus	virus	NOUN
biomedich-293	33	15	.	.	PUNCT
biomedich-293	34	1	gene	gene	NOUN
biomedich-293	34	2	e	e	NOUN
biomedich-293	34	3	encodes	encode	VERB
biomedich-293	34	4	a	a	DET
biomedich-293	34	5	small	small	ADJ
biomedich-293	34	6	multifunctional	multifunctional	ADJ
biomedich-293	34	7	protein	protein	NOUN
biomedich-293	34	8	that	that	PRON
biomedich-293	34	9	has	have	VERB
biomedich-293	34	10	ion	ion	NOUN
biomedich-293	34	11	channel	channel	NOUN
biomedich-293	34	12	(	(	PUNCT
biomedich-293	34	13	ic	ic	NOUN
biomedich-293	34	14	)	)	PUNCT
biomedich-293	34	15	activity	activity	NOUN
biomedich-293	34	16	,	,	PUNCT
biomedich-293	34	17	an	an	DET
biomedich-293	34	18	important	important	ADJ
biomedich-293	34	19	function	function	NOUN
biomedich-293	34	20	in	in	ADP
biomedich-293	34	21	virus	virus	NOUN
biomedich-293	34	22	-	-	PUNCT
biomedich-293	34	23	host	host	NOUN
biomedich-293	34	24	interactions	interaction	NOUN
biomedich-293	34	25	.	.	PUNCT
biomedich-293	35	1	to	to	PART
biomedich-293	35	2	examine	examine	VERB
biomedich-293	35	3	the	the	DET
biomedich-293	35	4	contribution	contribution	NOUN
biomedich-293	35	5	of	of	ADP
biomedich-293	35	6	the	the	DET
biomedich-293	35	7	ic	ic	PROPN
biomedich-293	35	8	activity	activity	NOUN
biomedich-293	35	9	of	of	ADP
biomedich-293	35	10	protein	protein	NOUN
biomedich-293	35	11	e	e	NOUN
biomedich-293	35	12	in	in	ADP
biomedich-293	35	13	viral	viral	ADJ
biomedich-293	35	14	pathogenesis	pathogenesis	NOUN
biomedich-293	35	15	,	,	PUNCT
biomedich-293	35	16	two	two	NUM
biomedich-293	35	17	mouse	mouse	NOUN
biomedich-293	35	18	-	-	PUNCT
biomedich-293	35	19	adapted	adapt	VERB
biomedich-293	35	20	sars	sar	NOUN
biomedich-293	35	21	-	-	PUNCT
biomedich-293	35	22	cov	cov	NOUN
biomedich-293	35	23	,	,	PUNCT
biomedich-293	35	24	each	each	PRON
biomedich-293	35	25	containing	contain	VERB
biomedich-293	35	26	a	a	DET
biomedich-293	35	27	single	single	ADJ
biomedich-293	35	28	amino	amino	NOUN
biomedich-293	35	29	acid	acid	NOUN
biomedich-293	35	30	mutation	mutation	NOUN
biomedich-293	35	31	that	that	PRON
biomedich-293	35	32	suppresses	suppress	VERB
biomedich-293	35	33	ion	ion	NOUN
biomedich-293	35	34	conductivity	conductivity	NOUN
biomedich-293	35	35	,	,	PUNCT
biomedich-293	35	36	were	be	AUX
biomedich-293	35	37	engineered	engineer	VERB
biomedich-293	35	38	.	.	PUNCT
biomedich-293	36	1	after	after	ADP
biomedich-293	36	2	serial	serial	ADJ
biomedich-293	36	3	infection	infection	NOUN
biomedich-293	36	4	,	,	PUNCT
biomedich-293	36	5	mutant	mutant	ADJ
biomedich-293	36	6	viruses	virus	NOUN
biomedich-293	36	7	,	,	PUNCT
biomedich-293	36	8	in	in	ADP
biomedich-293	36	9	general	general	ADJ
biomedich-293	36	10	,	,	PUNCT
biomedich-293	36	11	introduce	introduce	VERB
biomedich-293	36	12	compensatory	compensatory	ADJ
biomedich-293	36	13	mutations	mutation	NOUN
biomedich-293	36	14	in	in	ADP
biomedich-293	36	15	the	the	DET
biomedich-293	36	16	e	e	NOUN
biomedich-293	36	17	gene	gene	NOUN
biomedich-293	36	18	that	that	PRON
biomedich-293	36	19	create	create	VERB
biomedich-293	36	20	active	active	ADJ
biomedich-293	36	21	ion	ion	NOUN
biomedich-293	36	22	channels	channel	NOUN
biomedich-293	36	23	.	.	PUNCT
biomedich-293	37	1	furthermore	furthermore	ADV
biomedich-293	37	2	,	,	PUNCT
biomedich-293	37	3	ic	ic	PROPN
biomedich-293	37	4	activity	activity	NOUN
biomedich-293	37	5	provided	provide	VERB
biomedich-293	37	6	better	well	ADJ
biomedich-293	37	7	fitness	fitness	NOUN
biomedich-293	37	8	in	in	ADP
biomedich-293	37	9	competition	competition	NOUN
biomedich-293	37	10	assays	assay	NOUN
biomedich-293	37	11	,	,	PUNCT
biomedich-293	37	12	suggesting	suggest	VERB
biomedich-293	37	13	that	that	SCONJ
biomedich-293	37	14	ionic	ionic	ADJ
biomedich-293	37	15	conductivity	conductivity	NOUN
biomedich-293	37	16	is	be	AUX
biomedich-293	37	17	an	an	DET
biomedich-293	37	18	advantage	advantage	NOUN
biomedich-293	37	19	for	for	ADP
biomedich-293	37	20	viruses	virus	NOUN
biomedich-293	37	21	.	.	PUNCT
biomedich-293	38	1	interestingly	interestingly	ADV
biomedich-293	38	2	,	,	PUNCT
biomedich-293	38	3	virus	virus	NOUN
biomedich-293	38	4	-	-	PUNCT
biomedich-293	38	5	infected	infect	VERB
biomedich-293	38	6	mice	mouse	NOUN
biomedich-293	38	7	exhibiting	exhibit	VERB
biomedich-293	38	8	ic	ic	PROPN
biomedich-293	38	9	protein	protein	NOUN
biomedich-293	38	10	e	e	NOUN
biomedich-293	38	11	activity	activity	NOUN
biomedich-293	38	12	,	,	PUNCT
biomedich-293	38	13	either	either	CCONJ
biomedich-293	38	14	with	with	ADP
biomedich-293	38	15	a	a	DET
biomedich-293	38	16	wild	wild	ADJ
biomedich-293	38	17	-	-	PUNCT
biomedich-293	38	18	type	type	NOUN
biomedich-293	38	19	protein	protein	NOUN
biomedich-293	38	20	e	e	NOUN
biomedich-293	38	21	sequence	sequence	NOUN
biomedich-293	38	22	or	or	CCONJ
biomedich-293	38	23	with	with	ADP
biomedich-293	38	24	a	a	DET
biomedich-293	38	25	revertant	revertant	NOUN
biomedich-293	38	26	that	that	PRON
biomedich-293	38	27	restores	restore	VERB
biomedich-293	38	28	ion	ion	NOUN
biomedich-293	38	29	transport	transport	NOUN
biomedich-293	38	30	,	,	PUNCT
biomedich-293	38	31	rapidly	rapidly	ADV
biomedich-293	38	32	lost	lose	VERB
biomedich-293	38	33	weight	weight	NOUN
biomedich-293	38	34	and	and	CCONJ
biomedich-293	38	35	died	die	VERB
biomedich-293	38	36	.	.	PUNCT
biomedich-293	39	1	in	in	ADP
biomedich-293	39	2	contrast	contrast	NOUN
biomedich-293	39	3	,	,	PUNCT
biomedich-293	39	4	mice	mouse	NOUN
biomedich-293	39	5	infected	infect	VERB
biomedich-293	39	6	with	with	ADP
biomedich-293	39	7	a	a	DET
biomedich-293	39	8	mutant	mutant	NOUN
biomedich-293	39	9	lacking	lack	VERB
biomedich-293	39	10	ic	ic	NUM
biomedich-293	39	11	activity	activity	NOUN
biomedich-293	39	12	,	,	PUNCT
biomedich-293	39	13	which	which	PRON
biomedich-293	39	14	did	do	AUX
biomedich-293	39	15	not	not	PART
biomedich-293	39	16	introduce	introduce	VERB
biomedich-293	39	17	the	the	DET
biomedich-293	39	18	mutation	mutation	NOUN
biomedich-293	39	19	in	in	ADP
biomedich-293	39	20	the	the	DET
biomedich-293	39	21	e	e	NOUN
biomedich-293	39	22	gene	gene	NOUN
biomedich-293	39	23	during	during	ADP
biomedich-293	39	24	the	the	DET
biomedich-293	39	25	experiment	experiment	NOUN
biomedich-293	39	26	,	,	PUNCT
biomedich-293	39	27	recovered	recover	VERB
biomedich-293	39	28	from	from	ADP
biomedich-293	39	29	the	the	DET
biomedich-293	39	30	disease	disease	NOUN
biomedich-293	39	31	and	and	CCONJ
biomedich-293	39	32	mostly	mostly	ADV
biomedich-293	39	33	survived	survive	VERB
biomedich-293	39	34	.	.	PUNCT
biomedich-293	40	1	levels	level	NOUN
biomedich-293	40	2	of	of	ADP
biomedich-293	40	3	inflammasome	inflammasome	NOUN
biomedich-293	40	4	-	-	PUNCT
biomedich-293	40	5	activated	activate	VERB
biomedich-293	40	6	il-1β	il-1β	PROPN
biomedich-293	40	7	were	be	AUX
biomedich-293	40	8	reduced	reduce	VERB
biomedich-293	40	9	in	in	ADP
biomedich-293	40	10	the	the	DET
biomedich-293	40	11	lung	lung	NOUN
biomedich-293	40	12	airways	airways	PROPN
biomedich-293	40	13	of	of	ADP
biomedich-293	40	14	virus	virus	NOUN
biomedich-293	40	15	-	-	PUNCT
biomedich-293	40	16	infected	infect	VERB
biomedich-293	40	17	animals	animal	NOUN
biomedich-293	40	18	lacking	lack	VERB
biomedich-293	40	19	ic	ic	NUM
biomedich-293	40	20	protein	protein	NOUN
biomedich-293	40	21	e	e	NOUN
biomedich-293	40	22	activity	activity	NOUN
biomedich-293	40	23	,	,	PUNCT
biomedich-293	40	24	suggesting	suggest	VERB
biomedich-293	40	25	that	that	SCONJ
biomedich-293	40	26	ic	ic	PROPN
biomedich-293	40	27	protein	protein	NOUN
biomedich-293	40	28	e	e	NOUN
biomedich-293	40	29	function	function	NOUN
biomedich-293	40	30	is	be	AUX
biomedich-293	40	31	required	require	VERB
biomedich-293	40	32	for	for	ADP
biomedich-293	40	33	inflammasome	inflammasome	NOUN
biomedich-293	40	34	activation	activation	NOUN
biomedich-293	40	35	.	.	PUNCT
biomedich-293	41	1	the	the	DET
biomedich-293	41	2	reduction	reduction	NOUN
biomedich-293	41	3	in	in	ADP
biomedich-293	41	4	il-1β	il-1β	PROPN
biomedich-293	41	5	is	be	AUX
biomedich-293	41	6	accompanied	accompany	VERB
biomedich-293	41	7	by	by	ADP
biomedich-293	41	8	a	a	DET
biomedich-293	41	9	decrease	decrease	NOUN
biomedich-293	41	10	in	in	ADP
biomedich-293	41	11	the	the	DET
biomedich-293	41	12	number	number	NOUN
biomedich-293	41	13	of	of	ADP
biomedich-293	41	14	tnf	tnf	PROPN
biomedich-293	41	15	and	and	CCONJ
biomedich-293	41	16	il-6	il-6	NOUN
biomedich-293	41	17	in	in	ADP
biomedich-293	41	18	the	the	DET
biomedich-293	41	19	absence	absence	NOUN
biomedich-293	41	20	of	of	ADP
biomedich-293	41	21	ion	ion	NOUN
biomedich-293	41	22	conductivity	conductivity	NOUN
biomedich-293	41	23	protein	protein	NOUN
biomedich-293	41	24	e.	e.	PROPN
biomedich-293	41	25	all	all	PRON
biomedich-293	41	26	of	of	ADP
biomedich-293	41	27	these	these	DET
biomedich-293	41	28	key	key	ADJ
biomedich-293	41	29	cytokines	cytokine	NOUN
biomedich-293	41	30	promote	promote	VERB
biomedich-293	41	31	the	the	DET
biomedich-293	41	32	development	development	NOUN
biomedich-293	41	33	of	of	ADP
biomedich-293	41	34	lung	lung	NOUN
biomedich-293	41	35	damage	damage	NOUN
biomedich-293	41	36	and	and	CCONJ
biomedich-293	41	37	ards	ard	VERB
biomedich-293	41	38	pathology	pathology	PROPN
biomedich-293	41	39	.	.	PUNCT
biomedich-293	42	1	in	in	ADP
biomedich-293	42	2	conclusion	conclusion	NOUN
biomedich-293	42	3	,	,	PUNCT
biomedich-293	42	4	the	the	DET
biomedich-293	42	5	ic	ic	PROPN
biomedich-293	42	6	activity	activity	NOUN
biomedich-293	42	7	of	of	ADP
biomedich-293	42	8	protein	protein	NOUN
biomedich-293	42	9	e	e	NOUN
biomedich-293	42	10	is	be	AUX
biomedich-293	42	11	a	a	DET
biomedich-293	42	12	novel	novel	NOUN
biomedich-293	42	13	determinant	determinant	ADJ
biomedich-293	42	14	for	for	ADP
biomedich-293	42	15	the	the	DET
biomedich-293	42	16	virulence	virulence	NOUN
biomedich-293	42	17	of	of	ADP
biomedich-293	42	18	sars	sars	PROPN
biomedich-293	42	19	-	-	PUNCT
biomedich-293	42	20	cov	cov	PROPN
biomedich-293	42	21	(	(	PUNCT
biomedich-293	42	22	nieto	nieto	PROPN
biomedich-293	42	23	-	-	PUNCT
biomedich-293	42	24	torres	torres	PROPN
biomedich-293	42	25	,	,	PUNCT
biomedich-293	42	26	et	et	PROPN
biomedich-293	42	27	al	al	PROPN
biomedich-293	42	28	.	.	PROPN
biomedich-293	42	29	,	,	PUNCT
biomedich-293	42	30	2014	2014	NUM
biomedich-293	42	31	)	)	PUNCT
biomedich-293	42	32	.	.	PUNCT
biomedich-293	43	1	siu	siu	NOUN
biomedich-293	43	2	et	et	PROPN
biomedich-293	43	3	al	al	PROPN
biomedich-293	43	4	.	.	PROPN
biomedich-293	44	1	(	(	PUNCT
biomedich-293	44	2	2019	2019	NUM
biomedich-293	44	3	)	)	PUNCT
biomedich-293	44	4	demonstrated	demonstrate	VERB
biomedich-293	44	5	that	that	SCONJ
biomedich-293	44	6	the	the	DET
biomedich-293	44	7	open	open	ADJ
biomedich-293	44	8	reading	reading	NOUN
biomedich-293	44	9	frame	frame	NOUN
biomedich-293	44	10	3a	3a	NUM
biomedich-293	44	11	(	(	PUNCT
biomedich-293	44	12	orf3a	orf3a	NOUN
biomedich-293	44	13	)	)	PUNCT
biomedich-293	44	14	accessory	accessory	NOUN
biomedich-293	44	15	protein	protein	NOUN
biomedich-293	44	16	of	of	ADP
biomedich-293	44	17	sars	sar	NOUN
biomedich-293	44	18	-	-	PUNCT
biomedich-293	44	19	cov	cov	NOUN
biomedich-293	44	20	activates	activate	VERB
biomedich-293	44	21	the	the	DET
biomedich-293	44	22	nlrp3	nlrp3	ADJ
biomedich-293	44	23	inflammasome	inflammasome	NOUN
biomedich-293	44	24	by	by	ADP
biomedich-293	44	25	promoting	promote	VERB
biomedich-293	44	26	tnf	tnf	PROPN
biomedich-293	44	27	receptor	receptor	NOUN
biomedich-293	44	28	-	-	PUNCT
biomedich-293	44	29	associated	associate	VERB
biomedich-293	44	30	factor	factor	NOUN
biomedich-293	44	31	3	3	NUM
biomedich-293	44	32	(	(	PUNCT
biomedich-293	44	33	traf3)-mediated	traf3)-mediate	VERB
biomedich-293	44	34	ubiquitination	ubiquitination	NOUN
biomedich-293	44	35	of	of	ADP
biomedich-293	44	36	an	an	DET
biomedich-293	44	37	apoptosis	apoptosis	NOUN
biomedich-293	44	38	-	-	PUNCT
biomedich-293	44	39	associated	associate	VERB
biomedich-293	44	40	spot	spot	NOUN
biomedich-293	44	41	-	-	PUNCT
biomedich-293	44	42	like	like	ADJ
biomedich-293	44	43	protein	protein	NOUN
biomedich-293	44	44	containing	contain	VERB
biomedich-293	44	45	a	a	DET
biomedich-293	44	46	recruitment	recruitment	NOUN
biomedich-293	44	47	caspase	caspase	NOUN
biomedich-293	44	48	domain	domain	NOUN
biomedich-293	44	49	(	(	PUNCT
biomedich-293	44	50	asc	asc	PROPN
biomedich-293	44	51	)	)	PUNCT
biomedich-293	44	52	.	.	PUNCT
biomedich-293	45	1	sars	sars	PROPN
biomedich-293	45	2	-	-	PUNCT
biomedich-293	45	3	cov	cov	PROPN
biomedich-293	45	4	and	and	CCONJ
biomedich-293	45	5	its	its	PRON
biomedich-293	45	6	orf3a	orf3a	ADJ
biomedich-293	45	7	protein	protein	NOUN
biomedich-293	45	8	were	be	AUX
biomedich-293	45	9	found	find	VERB
biomedich-293	45	10	to	to	PART
biomedich-293	45	11	be	be	AUX
biomedich-293	45	12	potent	potent	ADJ
biomedich-293	45	13	activators	activator	NOUN
biomedich-293	45	14	of	of	ADP
biomedich-293	45	15	pro	pro	ADJ
biomedich-293	45	16	-	-	ADJ
biomedich-293	45	17	il-1β	il-1β	ADJ
biomedich-293	45	18	gene	gene	NOUN
biomedich-293	45	19	transcription	transcription	NOUN
biomedich-293	45	20	and	and	CCONJ
biomedich-293	45	21	protein	protein	NOUN
biomedich-293	45	22	maturation	maturation	NOUN
biomedich-293	45	23	,	,	PUNCT
biomedich-293	45	24	2	2	NUM
biomedich-293	45	25	signals	signal	NOUN
biomedich-293	45	26	required	require	VERB
biomedich-293	45	27	for	for	ADP
biomedich-293	45	28	nlrp3	nlrp3	NOUN
biomedich-293	45	29	inflammasome	inflammasome	NOUN
biomedich-293	45	30	activation	activation	NOUN
biomedich-293	45	31	.	.	PUNCT
biomedich-293	46	1	orf3a	orf3a	NOUN
biomedich-293	46	2	induces	induce	VERB
biomedich-293	46	3	pro	pro	ADJ
biomedich-293	46	4	-	-	ADJ
biomedich-293	46	5	il-1β	il-1β	ADJ
biomedich-293	46	6	transcription	transcription	NOUN
biomedich-293	46	7	via	via	ADP
biomedich-293	46	8	nf	nf	NOUN
biomedich-293	46	9	-	-	PUNCT
biomedich-293	46	10	b	b	NOUN
biomedich-293	46	11	activation	activation	NOUN
biomedich-293	46	12	,	,	PUNCT
biomedich-293	46	13	which	which	PRON
biomedich-293	46	14	is	be	AUX
biomedich-293	46	15	mediated	mediate	VERB
biomedich-293	46	16	by	by	ADP
biomedich-293	46	17	ubiquitination	ubiquitination	NOUN
biomedich-293	46	18	and	and	CCONJ
biomedich-293	46	19	traf3	traf3	NOUN
biomedich-293	46	20	-	-	PUNCT
biomedich-293	46	21	dependent	dependent	ADJ
biomedich-293	46	22	p105	p105	PROPN
biomedich-293	46	23	processing	processing	NOUN
biomedich-293	46	24	.	.	PUNCT
biomedich-293	47	1	orf3a	orf3a	NOUN
biomedich-293	47	2	-	-	PUNCT
biomedich-293	47	3	induced	induced	ADJ
biomedich-293	47	4	increase	increase	NOUN
biomedich-293	47	5	in	in	ADP
biomedich-293	47	6	il-1β	il-1β	PROPN
biomedich-293	47	7	secretion	secretion	NOUN
biomedich-293	47	8	is	be	AUX
biomedich-293	47	9	independent	independent	ADJ
biomedich-293	47	10	of	of	ADP
biomedich-293	47	11	its	its	PRON
biomedich-293	47	12	ion	ion	NOUN
biomedich-293	47	13	channel	channel	NOUN
biomedich-293	47	14	activity	activity	NOUN
biomedich-293	47	15	or	or	CCONJ
biomedich-293	47	16	is	be	AUX
biomedich-293	47	17	absent	absent	ADJ
biomedich-293	47	18	in	in	ADP
biomedich-293	47	19	melanoma	melanoma	NOUN
biomedich-293	47	20	2	2	NUM
biomedich-293	47	21	but	but	CCONJ
biomedich-293	47	22	requires	require	VERB
biomedich-293	47	23	nlrp3	nlrp3	PROPN
biomedich-293	47	24	,	,	PUNCT
biomedich-293	47	25	asc	asc	PROPN
biomedich-293	47	26	,	,	PUNCT
biomedich-293	47	27	and	and	CCONJ
biomedich-293	47	28	traf3	traf3	NOUN
biomedich-293	47	29	.	.	PUNCT
biomedich-293	48	1	orf3a	orf3a	NOUN
biomedich-293	48	2	interacts	interact	VERB
biomedich-293	48	3	with	with	ADP
biomedich-293	48	4	traf3	traf3	NOUN
biomedich-293	48	5	and	and	CCONJ
biomedich-293	48	6	asc	asc	PROPN
biomedich-293	48	7	,	,	PUNCT
biomedich-293	48	8	localizes	localize	VERB
biomedich-293	48	9	with	with	ADP
biomedich-293	48	10	them	they	PRON
biomedich-293	48	11	in	in	ADP
biomedich-293	48	12	discrete	discrete	ADJ
biomedich-293	48	13	mottled	mottle	VERB
biomedich-293	48	14	structures	structure	NOUN
biomedich-293	48	15	in	in	ADP
biomedich-293	48	16	the	the	DET
biomedich-293	48	17	cytoplasm	cytoplasm	NOUN
biomedich-293	48	18	,	,	PUNCT
biomedich-293	48	19	and	and	CCONJ
biomedich-293	48	20	facilitates	facilitate	VERB
biomedich-293	48	21	the	the	DET
biomedich-293	48	22	formation	formation	NOUN
biomedich-293	48	23	of	of	ADP
biomedich-293	48	24	asc	asc	PROPN
biomedich-293	48	25	specks	speck	NOUN
biomedich-293	48	26	.	.	PUNCT
biomedich-293	49	1	traf3dependent	traf3dependent	DET
biomedich-293	49	2	ubiquitination	ubiquitination	NOUN
biomedich-293	49	3	of	of	ADP
biomedich-293	49	4	k63	k63	NOUN
biomedich-293	49	5	-	-	PUNCT
biomedich-293	49	6	associated	associate	VERB
biomedich-293	49	7	ascs	ascs	NOUN
biomedich-293	49	8	was	be	AUX
biomedich-293	49	9	more	more	ADV
biomedich-293	49	10	prominent	prominent	ADJ
biomedich-293	49	11	in	in	ADP
biomedich-293	49	12	cells	cell	NOUN
biomedich-293	49	13	infected	infect	VERB
biomedich-293	49	14	with	with	ADP
biomedich-293	49	15	sars	sar	NOUN
biomedich-293	49	16	-	-	PUNCT
biomedich-293	49	17	cov	cov	NOUN
biomedich-293	49	18	or	or	CCONJ
biomedich-293	49	19	when	when	SCONJ
biomedich-293	49	20	orf3a	orf3a	PROPN
biomedich-293	49	21	was	be	AUX
biomedich-293	49	22	expressed	express	VERB
biomedich-293	49	23	.	.	PUNCT
biomedich-293	50	1	overall	overall	ADV
biomedich-293	50	2	,	,	PUNCT
biomedich-293	50	3	the	the	DET
biomedich-293	50	4	findings	finding	NOUN
biomedich-293	50	5	of	of	ADP
biomedich-293	50	6	siu	siu	NOUN
biomedich-293	50	7	,	,	PUNCT
biomedich-293	50	8	et	et	PROPN
biomedich-293	50	9	al	al	PROPN
biomedich-293	50	10	.	.	PROPN
biomedich-293	51	1	(	(	PUNCT
biomedich-293	51	2	2019	2019	NUM
biomedich-293	51	3	)	)	PUNCT
biomedich-293	51	4	revealed	reveal	VERB
biomedich-293	51	5	a	a	DET
biomedich-293	51	6	novel	novel	ADJ
biomedich-293	51	7	mechanism	mechanism	NOUN
biomedich-293	51	8	by	by	ADP
biomedich-293	51	9	which	which	PRON
biomedich-293	51	10	the	the	DET
biomedich-293	51	11	sars	sar	NOUN
biomedich-293	51	12	-	-	PUNCT
biomedich-293	51	13	cov	cov	NOUN
biomedich-293	51	14	protein	protein	NOUN
biomedich-293	51	15	orf3a	orf3a	NOUN
biomedich-293	51	16	activates	activate	VERB
biomedich-293	51	17	nf	nf	NOUN
biomedich-293	51	18	-	-	PUNCT
biomedich-293	51	19	b	b	NOUN
biomedich-293	51	20	and	and	CCONJ
biomedich-293	51	21	the	the	DET
biomedich-293	51	22	nlrp3	nlrp3	NOUN
biomedich-293	51	23	inflammasome	inflammasome	NOUN
biomedich-293	51	24	by	by	ADP
biomedich-293	51	25	promoting	promote	VERB
biomedich-293	51	26	p105	p105	PROPN
biomedich-293	51	27	and	and	CCONJ
biomedich-293	51	28	asc.siu	asc.siu	PROPN
biomedich-293	51	29	-	-	PUNCT
biomedich-293	51	30	dependent	dependent	ADJ
biomedich-293	51	31	ubiquitination	ubiquitination	NOUN
biomedich-293	51	32	of	of	ADP
biomedich-293	51	33	traf3	traf3	NOUN
biomedich-293	51	34	.	.	PUNCT
biomedich-293	52	1	the	the	DET
biomedich-293	52	2	severe	severe	ADJ
biomedich-293	52	3	acute	acute	ADJ
biomedich-293	52	4	respiratory	respiratory	ADJ
biomedich-293	52	5	syndrome	syndrome	NOUN
biomedich-293	52	6	coronavirus	coronavirus	NOUN
biomedich-293	52	7	orf3a	orf3a	NOUN
biomedich-293	52	8	protein	protein	NOUN
biomedich-293	52	9	activates	activate	VERB
biomedich-293	52	10	the	the	DET
biomedich-293	52	11	nlrp3	nlrp3	ADJ
biomedich-293	52	12	inflammasome	inflammasome	NOUN
biomedich-293	52	13	by	by	ADP
biomedich-293	52	14	promoting	promote	VERB
biomedich-293	52	15	traf3	traf3	NOUN
biomedich-293	52	16	-	-	PUNCT
biomedich-293	52	17	dependent	dependent	ADJ
biomedich-293	52	18	asc	asc	PROPN
biomedich-293	52	19	ubiquitination	ubiquitination	PROPN
biomedich-293	52	20	(	(	PUNCT
biomedich-293	52	21	siu	siu	PROPN
biomedich-293	52	22	,	,	PUNCT
biomedich-293	52	23	et	et	PROPN
biomedich-293	52	24	al	al	PROPN
biomedich-293	52	25	.	.	PROPN
biomedich-293	52	26	,	,	PUNCT
biomedich-293	52	27	2019	2019	NUM
biomedich-293	52	28	)	)	PUNCT
biomedich-293	52	29	.	.	PUNCT
biomedich-293	53	1	sars	sar	NOUN
biomedich-293	53	2	-	-	PUNCT
biomedich-293	53	3	cov-2	cov-2	PART
biomedich-293	53	4	appears	appear	VERB
biomedich-293	53	5	to	to	PART
biomedich-293	53	6	act	act	VERB
biomedich-293	53	7	on	on	ADP
biomedich-293	53	8	the	the	DET
biomedich-293	53	9	activation	activation	NOUN
biomedich-293	53	10	and	and	CCONJ
biomedich-293	53	11	maturation	maturation	NOUN
biomedich-293	53	12	of	of	ADP
biomedich-293	53	13	il-1β	il-1β	PROPN
biomedich-293	53	14	,	,	PUNCT
biomedich-293	53	15	which	which	PRON
biomedich-293	53	16	in	in	ADP
biomedich-293	53	17	turn	turn	NOUN
biomedich-293	53	18	activates	activate	VERB
biomedich-293	53	19	other	other	ADJ
biomedich-293	53	20	proinflammatory	proinflammatory	ADJ
biomedich-293	53	21	cytokines	cytokine	NOUN
biomedich-293	53	22	,	,	PUNCT
biomedich-293	53	23	such	such	ADJ
biomedich-293	53	24	as	as	ADP
biomedich-293	53	25	il-6	il-6	NUM
biomedich-293	53	26	and	and	CCONJ
biomedich-293	53	27	tnf	tnf	PROPN
biomedich-293	53	28	(	(	PUNCT
biomedich-293	53	29	dediego	dediego	PROPN
biomedich-293	53	30	,	,	PUNCT
biomedich-293	53	31	et	et	PROPN
biomedich-293	53	32	al	al	PROPN
biomedich-293	53	33	.	.	PROPN
biomedich-293	53	34	,	,	PUNCT
biomedich-293	53	35	2014	2014	NUM
biomedich-293	53	36	;	;	PUNCT
biomedich-293	53	37	nieto	nieto	PROPN
biomedich-293	53	38	-	-	PUNCT
biomedich-293	53	39	torres	torres	PROPN
biomedich-293	53	40	,	,	PUNCT
biomedich-293	53	41	et	et	PROPN
biomedich-293	53	42	al	al	PROPN
biomedich-293	53	43	.	.	PROPN
biomedich-293	53	44	,	,	PUNCT
biomedich-293	53	45	2014	2014	NUM
biomedich-293	53	46	;	;	PUNCT
biomedich-293	53	47	siu	siu	NOUN
biomedich-293	53	48	,	,	PUNCT
biomedich-293	53	49	et	et	PROPN
biomedich-293	53	50	al	al	PROPN
biomedich-293	53	51	.	.	PROPN
biomedich-293	53	52	,	,	PUNCT
biomedich-293	53	53	2019	2019	NUM
biomedich-293	53	54	)	)	PUNCT
biomedich-293	53	55	.	.	PUNCT
biomedich-293	54	1	sars	sars	PROPN
biomedich-293	54	2	-	-	PUNCT
biomedich-293	54	3	cov	cov	NOUN
biomedich-293	54	4	-	-	PUNCT
biomedich-293	54	5	infected	infect	VERB
biomedich-293	54	6	dcs	dcs	PROPN
biomedich-293	54	7	show	show	VERB
biomedich-293	54	8	low	low	ADJ
biomedich-293	54	9	expression	expression	NOUN
biomedich-293	54	10	of	of	ADP
biomedich-293	54	11	antiviral	antiviral	ADJ
biomedich-293	54	12	cytokines	cytokine	NOUN
biomedich-293	54	13	(	(	PUNCT
biomedich-293	54	14	interferon	interferon	NOUN
biomedich-293	54	15	[	[	X
biomedich-293	54	16	ifn	ifn	PROPN
biomedich-293	54	17	-	-	PUNCT
biomedich-293	54	18	α	α	NOUN
biomedich-293	54	19	]	]	X
biomedich-293	54	20	,	,	PUNCT
biomedich-293	54	21	ifn	ifn	PROPN
biomedich-293	54	22	-	-	PUNCT
biomedich-293	54	23	β	β	NOUN
biomedich-293	54	24	,	,	PUNCT
biomedich-293	54	25	ifn	ifn	PROPN
biomedich-293	54	26	-	-	PUNCT
biomedich-293	54	27	γ	γ	NOUN
biomedich-293	54	28	,	,	PUNCT
biomedich-293	54	29	and	and	CCONJ
biomedich-293	54	30	interleukin	interleukin	NOUN
biomedich-293	54	31	12p40	12p40	NUM
biomedich-293	55	1	[	[	X
biomedich-293	55	2	il-12p40	il-12p40	X
biomedich-293	55	3	]	]	X
biomedich-293	55	4	)	)	PUNCT
biomedich-293	55	5	,	,	PUNCT
biomedich-293	55	6	upregulation	upregulation	NOUN
biomedich-293	55	7	of	of	ADP
biomedich-293	55	8	proinflammatory	proinflammatory	ADJ
biomedich-293	55	9	cytokines	cytokine	NOUN
biomedich-293	55	10	(	(	PUNCT
biomedich-293	55	11	tumor	tumor	NOUN
biomedich-293	55	12	necrosis	necrosis	NOUN
biomedich-293	55	13	)	)	PUNCT
biomedich-293	55	14	.	.	PUNCT
biomedich-293	56	1	factors	factor	NOUN
biomedich-293	57	1	[	[	X
biomedich-293	57	2	tnf	tnf	PROPN
biomedich-293	57	3	-	-	PUNCT
biomedich-293	57	4	α	α	PROPN
biomedich-293	57	5	]	]	X
biomedich-293	57	6	and	and	CCONJ
biomedich-293	57	7	il-6	il-6	NUM
biomedich-293	57	8	)	)	PUNCT
biomedich-293	57	9	but	but	CCONJ
biomedich-293	57	10	significant	significant	ADJ
biomedich-293	57	11	upregulation	upregulation	NOUN
biomedich-293	57	12	of	of	ADP
biomedich-293	57	13	inflammatory	inflammatory	ADJ
biomedich-293	57	14	chemokines	chemokine	NOUN
biomedich-293	57	15	(	(	PUNCT
biomedich-293	57	16	macrophage	macrophage	ADJ
biomedich-293	57	17	inflammatory	inflammatory	ADJ
biomedich-293	57	18	protein	protein	NOUN
biomedich-293	57	19	1α	1α	NOUN
biomedich-293	58	1	[	[	X
biomedich-293	58	2	mip-1α	mip-1α	NOUN
biomedich-293	58	3	]	]	PUNCT
biomedich-293	58	4	,	,	PUNCT
biomedich-293	58	5	upregulated	upregulate	VERB
biomedich-293	58	6	on	on	ADP
biomedich-293	58	7	normal	normal	ADJ
biomedich-293	58	8	-	-	PUNCT
biomedich-293	58	9	expressed	express	VERB
biomedich-293	58	10	and	and	CCONJ
biomedich-293	58	11	secreted	secrete	VERB
biomedich-293	58	12	t	t	NOUN
biomedich-293	58	13	cell	cell	NOUN
biomedich-293	58	14	activation	activation	NOUN
biomedich-293	58	15	[	[	X
biomedich-293	58	16	rantes	rante	NOUN
biomedich-293	58	17	]	]	PUNCT
biomedich-293	58	18	)	)	PUNCT
biomedich-293	58	19	,	,	PUNCT
biomedich-293	58	20	interferon	interferon	ADJ
biomedich-293	58	21	-	-	PUNCT
biomedich-293	58	22	inducible	inducible	ADJ
biomedich-293	58	23	proteins	protein	NOUN
biomedich-293	58	24	from	from	ADP
biomedich-293	58	25	10	10	NUM
biomedich-293	58	26	kda	kda	NOUN
biomedich-293	59	1	[	[	X
biomedich-293	59	2	ip-10	ip-10	X
biomedich-293	59	3	]	]	X
biomedich-293	59	4	,	,	PUNCT
biomedich-293	59	5	and	and	CCONJ
biomedich-293	59	6	monocyte	monocyte	ADJ
biomedich-293	59	7	chemoattractant	chemoattractant	NOUN
biomedich-293	59	8	protein	protein	NOUN
biomedich-293	59	9	1	1	NUM
biomedich-293	59	10	[	[	X
biomedich-293	59	11	mcp1	mcp1	PROPN
biomedich-293	59	12	]	]	X
biomedich-293	59	13	)	)	PUNCT
biomedich-293	59	14	.	.	PUNCT
biomedich-293	60	1	therefore	therefore	ADV
biomedich-293	60	2	,	,	PUNCT
biomedich-293	60	3	il-1β	il-1β	PROPN
biomedich-293	60	4	is	be	AUX
biomedich-293	60	5	part	part	NOUN
biomedich-293	60	6	of	of	ADP
biomedich-293	60	7	the	the	DET
biomedich-293	60	8	cytokine	cytokine	NOUN
biomedich-293	60	9	storm	storm	NOUN
biomedich-293	60	10	generated	generate	VERB
biomedich-293	60	11	by	by	ADP
biomedich-293	60	12	coronavirus	coronavirus	NOUN
biomedich-293	60	13	infection	infection	NOUN
biomedich-293	60	14	(	(	PUNCT
biomedich-293	60	15	law	law	NOUN
biomedich-293	60	16	,	,	PUNCT
biomedich-293	60	17	et	et	PROPN
biomedich-293	60	18	al	al	PROPN
biomedich-293	60	19	.	.	PROPN
biomedich-293	60	20	,	,	PUNCT
biomedich-293	60	21	2005	2005	NUM
biomedich-293	60	22	;	;	PUNCT
biomedich-293	60	23	chu	chu	PROPN
biomedich-293	60	24	,	,	PUNCT
biomedich-293	60	25	et	et	PROPN
biomedich-293	60	26	al	al	PROPN
biomedich-293	60	27	.	.	PROPN
biomedich-293	60	28	,	,	PUNCT
biomedich-293	60	29	2016	2016	NUM
biomedich-293	60	30	;	;	PUNCT
biomedich-293	60	31	hui	hui	PROPN
biomedich-293	60	32	,	,	PUNCT
biomedich-293	60	33	et	et	PROPN
biomedich-293	60	34	al	al	PROPN
biomedich-293	60	35	.	.	PROPN
biomedich-293	60	36	,	,	PUNCT
biomedich-293	60	37	2019	2019	NUM
biomedich-293	60	38	;	;	PUNCT
biomedich-293	60	39	conti	conti	NOUN
biomedich-293	60	40	,	,	PUNCT
biomedich-293	60	41	et	et	PROPN
biomedich-293	60	42	al	al	PROPN
biomedich-293	60	43	.	.	PROPN
biomedich-293	60	44	,	,	PUNCT
biomedich-293	60	45	2020	2020	NUM
biomedich-293	60	46	;	;	PUNCT
biomedich-293	60	47	mehta	mehta	PROPN
biomedich-293	60	48	,	,	PUNCT
biomedich-293	60	49	et	et	PROPN
biomedich-293	60	50	al	al	PROPN
biomedich-293	60	51	.	.	PROPN
biomedich-293	60	52	,	,	PUNCT
biomedich-293	60	53	2020	2020	NUM
biomedich-293	60	54	;	;	PUNCT
biomedich-293	60	55	wan	wan	PROPN
biomedich-293	60	56	,	,	PUNCT
biomedich-293	60	57	et	et	PROPN
biomedich-293	60	58	al	al	PROPN
biomedich-293	60	59	.	.	PROPN
biomedich-293	60	60	,	,	PUNCT
biomedich-293	60	61	2020	2020	NUM
biomedich-293	60	62	)	)	PUNCT
biomedich-293	60	63	yang	yang	PROPN
biomedich-293	60	64	,	,	PUNCT
biomedich-293	60	65	et	et	PROPN
biomedich-293	60	66	al	al	PROPN
biomedich-293	60	67	.	.	PROPN
biomedich-293	61	1	(	(	PUNCT
biomedich-293	61	2	2020	2020	NUM
biomedich-293	61	3	)	)	PUNCT
biomedich-293	61	4	detected	detect	VERB
biomedich-293	61	5	elevated	elevated	ADJ
biomedich-293	61	6	levels	level	NOUN
biomedich-293	61	7	of	of	ADP
biomedich-293	61	8	the	the	DET
biomedich-293	61	9	il1	il1	PROPN
biomedich-293	61	10	receptor	receptor	NOUN
biomedich-293	61	11	antagonist	antagonist	NOUN
biomedich-293	61	12	(	(	PUNCT
biomedich-293	61	13	il-1ra	il-1ra	NOUN
biomedich-293	61	14	)	)	PUNCT
biomedich-293	61	15	in	in	ADP
biomedich-293	61	16	14	14	NUM
biomedich-293	61	17	severe	severe	ADJ
biomedich-293	61	18	cases	case	NOUN
biomedich-293	61	19	of	of	ADP
biomedich-293	61	20	covid-19	covid-19	PROPN
biomedich-293	61	21	,	,	PUNCT
biomedich-293	61	22	and	and	CCONJ
biomedich-293	61	23	this	this	DET
biomedich-293	61	24	marker	marker	NOUN
biomedich-293	61	25	has	have	AUX
biomedich-293	61	26	been	be	AUX
biomedich-293	61	27	associated	associate	VERB
biomedich-293	61	28	with	with	ADP
biomedich-293	61	29	increased	increase	VERB
biomedich-293	61	30	viral	viral	ADJ
biomedich-293	61	31	load	load	NOUN
biomedich-293	61	32	,	,	PUNCT
biomedich-293	61	33	loss	loss	NOUN
biomedich-293	61	34	of	of	ADP
biomedich-293	61	35	lung	lung	NOUN
biomedich-293	61	36	function	function	NOUN
biomedich-293	61	37	,	,	PUNCT
biomedich-293	61	38	lung	lung	NOUN
biomedich-293	61	39	damage	damage	NOUN
biomedich-293	61	40	,	,	PUNCT
biomedich-293	61	41	and	and	CCONJ
biomedich-293	61	42	risk	risk	NOUN
biomedich-293	61	43	of	of	ADP
biomedich-293	61	44	death	death	NOUN
biomedich-293	61	45	.	.	PUNCT
biomedich-293	62	1	liu	liu	PROPN
biomedich-293	62	2	,	,	PUNCT
biomedich-293	62	3	et	et	PROPN
biomedich-293	62	4	al	al	PROPN
biomedich-293	62	5	.	.	PROPN
biomedich-293	62	6	(	(	PUNCT
biomedich-293	62	7	2020	2020	NUM
biomedich-293	62	8	)	)	PUNCT
biomedich-293	62	9	also	also	ADV
biomedich-293	62	10	found	find	VERB
biomedich-293	62	11	elevated	elevated	ADJ
biomedich-293	62	12	levels	level	NOUN
biomedich-293	62	13	of	of	ADP
biomedich-293	62	14	il-1α	il-1α	PROPN
biomedich-293	62	15	in	in	ADP
biomedich-293	62	16	patients	patient	NOUN
biomedich-293	62	17	with	with	ADP
biomedich-293	62	18	severe	severe	ADJ
biomedich-293	62	19	covid-19	covid-19	PROPN
biomedich-293	62	20	,	,	PUNCT
biomedich-293	62	21	and	and	CCONJ
biomedich-293	62	22	this	this	PRON
biomedich-293	62	23	was	be	AUX
biomedich-293	62	24	strongly	strongly	ADV
biomedich-293	62	25	associated	associate	VERB
biomedich-293	62	26	with	with	ADP
biomedich-293	62	27	lung	lung	NOUN
biomedich-293	62	28	injury	injury	NOUN
biomedich-293	62	29	.	.	PUNCT
biomedich-293	63	1	il-1	il-1	PUNCT
biomedich-293	63	2	levels	level	NOUN
biomedich-293	63	3	are	be	AUX
biomedich-293	63	4	associated	associate	VERB
biomedich-293	63	5	with	with	ADP
biomedich-293	63	6	the	the	DET
biomedich-293	63	7	virulence	virulence	NOUN
biomedich-293	63	8	of	of	ADP
biomedich-293	63	9	the	the	DET
biomedich-293	63	10	process	process	NOUN
biomedich-293	63	11	,	,	PUNCT
biomedich-293	63	12	and	and	CCONJ
biomedich-293	63	13	significantly	significantly	ADV
biomedich-293	63	14	higher	high	ADJ
biomedich-293	63	15	serum	serum	NOUN
biomedich-293	63	16	levels	level	NOUN
biomedich-293	63	17	have	have	AUX
biomedich-293	63	18	been	be	AUX
biomedich-293	63	19	observed	observe	VERB
biomedich-293	63	20	in	in	ADP
biomedich-293	63	21	severe	severe	ADJ
biomedich-293	63	22	symptomatic	symptomatic	ADJ
biomedich-293	63	23	sars	sar	NOUN
biomedich-293	63	24	-	-	PUNCT
biomedich-293	63	25	cov-2	cov-2	PART
biomedich-293	63	26	cases	case	NOUN
biomedich-293	63	27	than	than	ADP
biomedich-293	63	28	in	in	ADP
biomedich-293	63	29	mild	mild	ADJ
biomedich-293	63	30	cases	case	NOUN
biomedich-293	63	31	or	or	CCONJ
biomedich-293	63	32	in	in	ADP
biomedich-293	63	33	those	those	PRON
biomedich-293	63	34	infected	infect	VERB
biomedich-293	63	35	with	with	ADP
biomedich-293	63	36	the	the	DET
biomedich-293	63	37	2003	2003	NUM
biomedich-293	63	38	sars	sar	NOUN
biomedich-293	63	39	-	-	PUNCT
biomedich-293	63	40	cov	cov	NOUN
biomedich-293	63	41	coronavirus	coronavirus	NOUN
biomedich-293	63	42	or	or	CCONJ
biomedich-293	63	43	2012	2012	NUM
biomedich-293	63	44	mers	mer	NOUN
biomedich-293	63	45	.	.	PUNCT
biomedich-293	64	1	covid-19	covid-19	PROPN
biomedich-293	64	2	patients	patient	NOUN
biomedich-293	64	3	with	with	ADP
biomedich-293	64	4	severe	severe	ADJ
biomedich-293	64	5	symptoms	symptom	NOUN
biomedich-293	64	6	have	have	VERB
biomedich-293	64	7	elevated	elevated	ADJ
biomedich-293	64	8	levels	level	NOUN
biomedich-293	64	9	of	of	ADP
biomedich-293	64	10	il-1β	il-1β	PROPN
biomedich-293	64	11	,	,	PUNCT
biomedich-293	64	12	which	which	PRON
biomedich-293	64	13	has	have	AUX
biomedich-293	64	14	been	be	AUX
biomedich-293	64	15	associated	associate	VERB
biomedich-293	64	16	with	with	ADP
biomedich-293	64	17	sars	sar	NOUN
biomedich-293	64	18	,	,	PUNCT
biomedich-293	64	19	hypercoagulation	hypercoagulation	NOUN
biomedich-293	64	20	,	,	PUNCT
biomedich-293	64	21	and	and	CCONJ
biomedich-293	64	22	disseminated	disseminate	VERB
biomedich-293	64	23	intravascular	intravascular	ADJ
biomedich-293	64	24	coagulation	coagulation	NOUN
biomedich-293	64	25	(	(	PUNCT
biomedich-293	64	26	zhang	zhang	PROPN
biomedich-293	64	27	,	,	PUNCT
biomedich-293	64	28	et	et	PROPN
biomedich-293	64	29	al	al	PROPN
biomedich-293	64	30	.	.	PROPN
biomedich-293	64	31	,	,	PUNCT
biomedich-293	64	32	2020	2020	NUM
biomedich-293	64	33	)	)	PUNCT
biomedich-293	64	34	.	.	PUNCT
biomedich-293	65	1	for	for	ADP
biomedich-293	65	2	this	this	DET
biomedich-293	65	3	reason	reason	NOUN
biomedich-293	65	4	,	,	PUNCT
biomedich-293	65	5	several	several	ADJ
biomedich-293	65	6	therapeutic	therapeutic	ADJ
biomedich-293	65	7	strategies	strategy	NOUN
biomedich-293	65	8	have	have	AUX
biomedich-293	65	9	used	use	VERB
biomedich-293	65	10	il-1	il-1	ADP
biomedich-293	65	11	inhibition	inhibition	NOUN
biomedich-293	65	12	in	in	ADP
biomedich-293	65	13	an	an	DET
biomedich-293	65	14	attempt	attempt	NOUN
biomedich-293	65	15	to	to	PART
biomedich-293	65	16	avoid	avoid	VERB
biomedich-293	65	17	cytokine	cytokine	ADJ
biomedich-293	65	18	storms	storm	NOUN
biomedich-293	65	19	(	(	PUNCT
biomedich-293	65	20	tanaka	tanaka	PROPN
biomedich-293	65	21	,	,	PUNCT
biomedich-293	65	22	et	et	PROPN
biomedich-293	65	23	al	al	PROPN
biomedich-293	65	24	.	.	PROPN
biomedich-293	65	25	,	,	PUNCT
biomedich-293	65	26	2016	2016	NUM
biomedich-293	65	27	;	;	PUNCT
biomedich-293	65	28	kritas	krita	NOUN
biomedich-293	65	29	,	,	PUNCT
biomedich-293	65	30	et	et	PROPN
biomedich-293	65	31	al	al	PROPN
biomedich-293	65	32	.	.	PROPN
biomedich-293	65	33	,	,	PUNCT
biomedich-293	65	34	2020	2020	NUM
biomedich-293	65	35	)	)	PUNCT
biomedich-293	65	36	.	.	PUNCT
biomedich-293	66	1	in	in	ADP
biomedich-293	66	2	this	this	DET
biomedich-293	66	3	way	way	NOUN
biomedich-293	66	4	,	,	PUNCT
biomedich-293	66	5	mesenchymal	mesenchymal	ADJ
biomedich-293	66	6	stem	stem	NOUN
biomedich-293	66	7	cells	cell	NOUN
biomedich-293	66	8	(	(	PUNCT
biomedich-293	66	9	mscs	msc	NOUN
biomedich-293	66	10	)	)	PUNCT
biomedich-293	66	11	have	have	AUX
biomedich-293	66	12	been	be	AUX
biomedich-293	66	13	used	use	VERB
biomedich-293	66	14	to	to	PART
biomedich-293	66	15	savitri	savitri	VERB
biomedich-293	66	16	et	et	PROPN
biomedich-293	66	17	al	al	PROPN
biomedich-293	66	18	.	.	PROPN
biomedich-293	67	1	–	–	PUNCT
biomedich-293	67	2	interleukin-1	interleukin-1	NOUN
biomedich-293	67	3	as	as	ADP
biomedich-293	67	4	a	a	DET
biomedich-293	67	5	predictor	predictor	NOUN
biomedich-293	67	6	cytokine	cytokine	NOUN
biomedich-293	67	7	sars	sar	NOUN
biomedich-293	67	8	-	-	PUNCT
biomedich-293	67	9	cov	cov	NOUN
biomedich-293	67	10	:	:	PUNCT
biomedich-293	67	11	article	article	NOUN
biomedich-293	67	12	review	review	VERB
biomedich-293	67	13	189	189	NUM
biomedich-293	67	14	inhibit	inhibit	NOUN
biomedich-293	67	15	proinflammatory	proinflammatory	ADJ
biomedich-293	67	16	cytokines	cytokine	NOUN
biomedich-293	67	17	such	such	ADJ
biomedich-293	67	18	as	as	ADP
biomedich-293	67	19	il-1α	il-1α	PROPN
biomedich-293	67	20	and	and	CCONJ
biomedich-293	67	21	tnf	tnf	PROPN
biomedich-293	67	22	(	(	PUNCT
biomedich-293	67	23	chen	chen	PROPN
biomedich-293	67	24	,	,	PUNCT
biomedich-293	67	25	et	et	PROPN
biomedich-293	67	26	al	al	PROPN
biomedich-293	67	27	.	.	PROPN
biomedich-293	67	28	,	,	PUNCT
biomedich-293	67	29	2020	2020	NUM
biomedich-293	67	30	)	)	PUNCT
biomedich-293	67	31	.	.	PUNCT
biomedich-293	68	1	conclusions	conclusion	NOUN
biomedich-293	68	2	the	the	DET
biomedich-293	68	3	conclusions	conclusion	NOUN
biomedich-293	68	4	of	of	ADP
biomedich-293	68	5	the	the	DET
biomedich-293	68	6	study	study	NOUN
biomedich-293	68	7	may	may	AUX
biomedich-293	68	8	be	be	AUX
biomedich-293	68	9	presented	present	VERB
biomedich-293	68	10	in	in	ADP
biomedich-293	68	11	here.il-1	here.il-1	PROPN
biomedich-293	68	12	actively	actively	ADV
biomedich-293	68	13	participates	participate	VERB
biomedich-293	68	14	in	in	ADP
biomedich-293	68	15	the	the	DET
biomedich-293	68	16	inflammatory	inflammatory	ADJ
biomedich-293	68	17	response	response	NOUN
biomedich-293	68	18	to	to	ADP
biomedich-293	68	19	infection	infection	NOUN
biomedich-293	68	20	.	.	PUNCT
biomedich-293	69	1	sars	sar	NOUN
biomedich-293	69	2	-	-	PUNCT
biomedich-293	69	3	cov-2	cov-2	PART
biomedich-293	69	4	appears	appear	VERB
biomedich-293	69	5	to	to	PART
biomedich-293	69	6	act	act	VERB
biomedich-293	69	7	on	on	ADP
biomedich-293	69	8	the	the	DET
biomedich-293	69	9	activation	activation	NOUN
biomedich-293	69	10	and	and	CCONJ
biomedich-293	69	11	maturation	maturation	NOUN
biomedich-293	69	12	of	of	ADP
biomedich-293	69	13	il-1β	il-1β	PROPN
biomedich-293	69	14	,	,	PUNCT
biomedich-293	69	15	which	which	PRON
biomedich-293	69	16	in	in	ADP
biomedich-293	69	17	turn	turn	NOUN
biomedich-293	69	18	activates	activate	VERB
biomedich-293	69	19	other	other	ADJ
biomedich-293	69	20	proinflammatory	proinflammatory	ADJ
biomedich-293	69	21	cytokines	cytokine	NOUN
biomedich-293	69	22	,	,	PUNCT
biomedich-293	69	23	such	such	ADJ
biomedich-293	69	24	as	as	ADP
biomedich-293	69	25	il-6	il-6	NUM
biomedich-293	69	26	and	and	CCONJ
biomedich-293	69	27	tnf-	tnf-	X
biomedich-293	69	28	.	.	PUNCT
biomedich-293	70	1	therefore	therefore	ADV
biomedich-293	70	2	,	,	PUNCT
biomedich-293	70	3	il-1β	il-1β	PROPN
biomedich-293	70	4	is	be	AUX
biomedich-293	70	5	part	part	NOUN
biomedich-293	70	6	of	of	ADP
biomedich-293	70	7	the	the	DET
biomedich-293	70	8	cytokine	cytokine	NOUN
biomedich-293	70	9	storm	storm	NOUN
biomedich-293	70	10	generated	generate	VERB
biomedich-293	70	11	by	by	ADP
biomedich-293	70	12	coronavirus	coronavirus	NOUN
biomedich-293	70	13	infection	infection	NOUN
biomedich-293	70	14	.	.	PUNCT
biomedich-293	71	1	elevated	elevated	ADJ
biomedich-293	71	2	levels	level	NOUN
biomedich-293	71	3	of	of	ADP
biomedich-293	71	4	the	the	DET
biomedich-293	71	5	il-1	il-1	NOUN
biomedich-293	71	6	receptor	receptor	NOUN
biomedich-293	71	7	antagonist	antagonist	NOUN
biomedich-293	71	8	(	(	PUNCT
biomedich-293	71	9	il-1ra	il-1ra	NOUN
biomedich-293	71	10	)	)	PUNCT
biomedich-293	71	11	in	in	ADP
biomedich-293	71	12	severe	severe	ADJ
biomedich-293	71	13	cases	case	NOUN
biomedich-293	71	14	of	of	ADP
biomedich-293	71	15	covid-19	covid-19	PROPN
biomedich-293	71	16	,	,	PUNCT
biomedich-293	71	17	and	and	CCONJ
biomedich-293	71	18	this	this	DET
biomedich-293	71	19	marker	marker	NOUN
biomedich-293	71	20	have	have	AUX
biomedich-293	71	21	been	be	AUX
biomedich-293	71	22	associated	associate	VERB
biomedich-293	71	23	with	with	ADP
biomedich-293	71	24	increased	increase	VERB
biomedich-293	71	25	viral	viral	ADJ
biomedich-293	71	26	load	load	NOUN
biomedich-293	71	27	,	,	PUNCT
biomedich-293	71	28	loss	loss	NOUN
biomedich-293	71	29	of	of	ADP
biomedich-293	71	30	lung	lung	NOUN
biomedich-293	71	31	function	function	NOUN
biomedich-293	71	32	,	,	PUNCT
biomedich-293	71	33	lung	lung	NOUN
biomedich-293	71	34	damage	damage	NOUN
biomedich-293	71	35	,	,	PUNCT
biomedich-293	71	36	and	and	CCONJ
biomedich-293	71	37	risk	risk	NOUN
biomedich-293	71	38	of	of	ADP
biomedich-293	71	39	death	death	NOUN
biomedich-293	71	40	.	.	PUNCT
biomedich-293	72	1	in	in	ADP
biomedich-293	72	2	addition	addition	NOUN
biomedich-293	72	3	,	,	PUNCT
biomedich-293	72	4	there	there	PRON
biomedich-293	72	5	is	be	VERB
biomedich-293	72	6	an	an	DET
biomedich-293	72	7	increase	increase	NOUN
biomedich-293	72	8	in	in	ADP
biomedich-293	72	9	il1α	il1α	PROPN
biomedich-293	72	10	levels	level	NOUN
biomedich-293	72	11	in	in	ADP
biomedich-293	72	12	patients	patient	NOUN
biomedich-293	72	13	with	with	ADP
biomedich-293	72	14	severe	severe	ADJ
biomedich-293	72	15	covid-19	covid-19	PROPN
biomedich-293	72	16	,	,	PUNCT
biomedich-293	72	17	and	and	CCONJ
biomedich-293	72	18	this	this	PRON
biomedich-293	72	19	is	be	AUX
biomedich-293	72	20	strongly	strongly	ADV
biomedich-293	72	21	associated	associate	VERB
biomedich-293	72	22	with	with	ADP
biomedich-293	72	23	lung	lung	NOUN
biomedich-293	72	24	injury	injury	NOUN
biomedich-293	72	25	.	.	PUNCT
biomedich-293	73	1	il-1	il-1	PUNCT
biomedich-293	73	2	levels	level	NOUN
biomedich-293	73	3	are	be	AUX
biomedich-293	73	4	associated	associate	VERB
biomedich-293	73	5	with	with	ADP
biomedich-293	73	6	the	the	DET
biomedich-293	73	7	virulence	virulence	NOUN
biomedich-293	73	8	of	of	ADP
biomedich-293	73	9	the	the	DET
biomedich-293	73	10	process	process	NOUN
biomedich-293	73	11	,	,	PUNCT
biomedich-293	73	12	and	and	CCONJ
biomedich-293	73	13	significantly	significantly	ADV
biomedich-293	73	14	higher	high	ADJ
biomedich-293	73	15	serum	serum	NOUN
biomedich-293	73	16	levels	level	NOUN
biomedich-293	73	17	have	have	AUX
biomedich-293	73	18	been	be	AUX
biomedich-293	73	19	observed	observe	VERB
biomedich-293	73	20	in	in	ADP
biomedich-293	73	21	severe	severe	ADJ
biomedich-293	73	22	symptomatic	symptomatic	ADJ
biomedich-293	73	23	sars	sar	NOUN
biomedich-293	73	24	-	-	PUNCT
biomedich-293	73	25	cov-2	cov-2	PART
biomedich-293	73	26	cases	case	NOUN
biomedich-293	73	27	than	than	ADP
biomedich-293	73	28	in	in	ADP
biomedich-293	73	29	mild	mild	ADJ
biomedich-293	73	30	cases	case	NOUN
biomedich-293	73	31	or	or	CCONJ
biomedich-293	73	32	in	in	ADP
biomedich-293	73	33	those	those	PRON
biomedich-293	73	34	infected	infect	VERB
biomedich-293	73	35	with	with	ADP
biomedich-293	73	36	the	the	DET
biomedich-293	73	37	2003	2003	NUM
biomedich-293	73	38	sars	sar	NOUN
biomedich-293	73	39	-	-	PUNCT
biomedich-293	73	40	cov	cov	NOUN
biomedich-293	73	41	coronavirus	coronavirus	NOUN
biomedich-293	73	42	or	or	CCONJ
biomedich-293	73	43	2012	2012	NUM
biomedich-293	73	44	mers	mer	NOUN
biomedich-293	73	45	coronavirus	coronavirus	NOUN
biomedich-293	73	46	.	.	PUNCT
biomedich-293	74	1	acknowledgements	acknowledgement	NOUN
biomedich-293	74	2	:	:	PUNCT
biomedich-293	74	3	acknowledgments	acknowledgment	NOUN
biomedich-293	74	4	are	be	AUX
biomedich-293	74	5	expressed	express	VERB
biomedich-293	74	6	in	in	ADP
biomedich-293	74	7	a	a	DET
biomedich-293	74	8	brief	brief	NOUN
biomedich-293	74	9	;	;	PUNCT
biomedich-293	74	10	all	all	DET
biomedich-293	74	11	sources	source	NOUN
biomedich-293	74	12	of	of	ADP
biomedich-293	74	13	institutional	institutional	ADJ
biomedich-293	74	14	,	,	PUNCT
biomedich-293	74	15	private	private	ADJ
biomedich-293	74	16	and	and	CCONJ
biomedich-293	74	17	corporate	corporate	ADJ
biomedich-293	74	18	financial	financial	ADJ
biomedich-293	74	19	support	support	NOUN
biomedich-293	74	20	for	for	ADP
biomedich-293	74	21	the	the	DET
biomedich-293	74	22	work	work	NOUN
biomedich-293	74	23	must	must	AUX
biomedich-293	74	24	be	be	AUX
biomedich-293	74	25	fully	fully	ADV
biomedich-293	74	26	acknowledged	acknowledge	VERB
biomedich-293	74	27	,	,	PUNCT
biomedich-293	74	28	and	and	CCONJ
biomedich-293	74	29	any	any	DET
biomedich-293	74	30	potential	potential	ADJ
biomedich-293	74	31	conflicts	conflict	NOUN
biomedich-293	74	32	of	of	ADP
biomedich-293	74	33	interest	interest	NOUN
biomedich-293	74	34	are	be	AUX
biomedich-293	74	35	noted.the	noted.the	DET
biomedich-293	74	36	author	author	NOUN
biomedich-293	74	37	would	would	AUX
biomedich-293	74	38	like	like	VERB
biomedich-293	74	39	to	to	PART
biomedich-293	74	40	thank	thank	VERB
biomedich-293	74	41	the	the	DET
biomedich-293	74	42	institute	institute	NOUN
biomedich-293	74	43	for	for	ADP
biomedich-293	74	44	research	research	NOUN
biomedich-293	74	45	,	,	PUNCT
biomedich-293	74	46	development	development	NOUN
biomedich-293	74	47	,	,	PUNCT
biomedich-293	74	48	and	and	CCONJ
biomedich-293	74	49	community	community	NOUN
biomedich-293	74	50	service	service	NOUN
biomedich-293	74	51	(	(	PUNCT
biomedich-293	74	52	lp3	lp3	NOUN
biomedich-293	74	53	m	m	PROPN
biomedich-293	74	54	)	)	PUNCT
biomedich-293	74	55	of	of	ADP
biomedich-293	74	56	kadiri	kadiri	PROPN
biomedich-293	74	57	university	university	PROPN
biomedich-293	74	58	which	which	PRON
biomedich-293	74	59	has	have	AUX
biomedich-293	74	60	always	always	ADV
biomedich-293	74	61	provided	provide	VERB
biomedich-293	74	62	support	support	NOUN
biomedich-293	74	63	for	for	ADP
biomedich-293	74	64	writing	writing	NOUN
biomedich-293	74	65	and	and	CCONJ
biomedich-293	74	66	publications	publication	NOUN
biomedich-293	74	67	.	.	PUNCT
biomedich-293	75	1	authors	author	NOUN
biomedich-293	75	2	’	'	PUNCT
biomedich-293	75	3	contributions	contribution	NOUN
biomedich-293	75	4	:	:	PUNCT
biomedich-293	75	5	lisa	lisa	PROPN
biomedich-293	75	6	savitri	savitri	PROPN
biomedich-293	75	7	designed	design	VERB
biomedich-293	75	8	the	the	DET
biomedich-293	75	9	study	study	NOUN
biomedich-293	75	10	.	.	PUNCT
biomedich-293	76	1	lisa	lisa	PROPN
biomedich-293	76	2	savitri	savitri	PROPN
biomedich-293	76	3	and	and	CCONJ
biomedich-293	76	4	elfred	elfre	VERB
biomedich-293	76	5	rinaldo	rinaldo	PROPN
biomedich-293	76	6	kasimo	kasimo	PROPN
biomedich-293	76	7	analyzed	analyze	VERB
biomedich-293	76	8	the	the	DET
biomedich-293	76	9	articles	article	NOUN
biomedich-293	76	10	.	.	PUNCT
biomedich-293	77	1	lisa	lisa	PROPN
biomedich-293	77	2	savitri	savitri	PROPN
biomedich-293	77	3	,	,	PUNCT
biomedich-293	77	4	elfred	elfre	VERB
biomedich-293	77	5	rinaldo	rinaldo	PROPN
biomedich-293	77	6	kasimo	kasimo	PROPN
biomedich-293	77	7	,	,	PUNCT
biomedich-293	77	8	rochmad	rochmad	ADJ
biomedich-293	77	9	krissanjaya	krissanjaya	NOUN
biomedich-293	77	10	,	,	PUNCT
biomedich-293	77	11	syntia	syntia	PROPN
biomedich-293	77	12	tanu	tanu	PROPN
biomedich-293	77	13	juwita	juwita	PROPN
biomedich-293	77	14	,	,	PUNCT
biomedich-293	77	15	ester	ester	NOUN
biomedich-293	77	16	lianawati	lianawati	PROPN
biomedich-293	77	17	antoro	antoro	PROPN
biomedich-293	77	18	,	,	PUNCT
biomedich-293	77	19	ida	ida	PROPN
biomedich-293	77	20	septika	septika	PROPN
biomedich-293	77	21	wulansari	wulansari	PROPN
biomedich-293	77	22	wrote	write	VERB
biomedich-293	77	23	the	the	DET
biomedich-293	77	24	manuscript	manuscript	NOUN
biomedich-293	77	25	.	.	PUNCT
biomedich-293	78	1	all	all	DET
biomedich-293	78	2	authors	author	NOUN
biomedich-293	78	3	read	read	VERB
biomedich-293	78	4	and	and	CCONJ
biomedich-293	78	5	approved	approve	VERB
biomedich-293	78	6	the	the	DET
biomedich-293	78	7	final	final	ADJ
biomedich-293	78	8	version	version	NOUN
biomedich-293	78	9	of	of	ADP
biomedich-293	78	10	the	the	DET
biomedich-293	78	11	manuscript	manuscript	NOUN
biomedich-293	78	12	.	.	PUNCT
biomedich-293	79	1	competing	compete	VERB
biomedich-293	79	2	interests	interest	NOUN
biomedich-293	79	3	:	:	PUNCT
biomedich-293	79	4	the	the	DET
biomedich-293	79	5	authors	author	NOUN
biomedich-293	79	6	declare	declare	VERB
biomedich-293	79	7	that	that	SCONJ
biomedich-293	79	8	there	there	PRON
biomedich-293	79	9	are	be	VERB
biomedich-293	79	10	no	no	DET
biomedich-293	79	11	competing	compete	VERB
biomedich-293	79	12	interests	interest	NOUN
biomedich-293	79	13	.	.	PUNCT
biomedich-293	80	1	funding	funding	NOUN
biomedich-293	80	2	:	:	PUNCT
biomedich-293	80	3	the	the	DET
biomedich-293	80	4	authors	author	NOUN
biomedich-293	80	5	stated	state	VERB
biomedich-293	80	6	there	there	PRON
biomedich-293	80	7	was	be	VERB
biomedich-293	80	8	no	no	DET
biomedich-293	80	9	funding	funding	NOUN
biomedich-293	80	10	.	.	PUNCT
biomedich-293	81	1	references	reference	NOUN
biomedich-293	81	2	chen	chen	PROPN
biomedich-293	81	3	c.	c.	PROPN
biomedich-293	81	4	,	,	PUNCT
biomedich-293	81	5	zhang	zhang	PROPN
biomedich-293	81	6	x.r	x.r	PROPN
biomedich-293	81	7	.	.	PROPN
biomedich-293	81	8	,	,	PUNCT
biomedich-293	81	9	ju	ju	PROPN
biomedich-293	81	10	z.y	z.y	PROPN
biomedich-293	81	11	.	.	PROPN
biomedich-293	81	12	,	,	PUNCT
biomedich-293	81	13	he	he	PRON
biomedich-293	81	14	w.f	w.f	PROPN
biomedich-293	81	15	.	.	PUNCT
biomedich-293	82	1	(	(	PUNCT
biomedich-293	82	2	2020	2020	NUM
biomedich-293	82	3	)	)	PUNCT
biomedich-293	82	4	advances	advance	NOUN
biomedich-293	82	5	in	in	ADP
biomedich-293	82	6	the	the	DET
biomedich-293	82	7	research	research	NOUN
biomedich-293	82	8	of	of	ADP
biomedich-293	82	9	cytokine	cytokine	ADJ
biomedich-293	82	10	storm	storm	NOUN
biomedich-293	82	11	mechanism	mechanism	NOUN
biomedich-293	82	12	induced	induce	VERB
biomedich-293	82	13	by	by	ADP
biomedich-293	82	14	corona	corona	NOUN
biomedich-293	82	15	virus	virus	NOUN
biomedich-293	82	16	disease	disease	NOUN
biomedich-293	82	17	2019and	2019and	CCONJ
biomedich-293	82	18	the	the	DET
biomedich-293	82	19	corresponding	corresponding	ADJ
biomedich-293	82	20	immunotherapies	immunotherapy	NOUN
biomedich-293	82	21	.	.	PUNCT
biomedich-293	83	1	zhonghua	zhonghua	PROPN
biomedich-293	83	2	shao	shao	PROPN
biomedich-293	83	3	shang	shang	PROPN
biomedich-293	83	4	za	za	PROPN
biomedich-293	83	5	zhi	zhi	PROPN
biomedich-293	83	6	.	.	PUNCT
biomedich-293	84	1	2020;36	2020;36	NUM
biomedich-293	84	2	:	:	PUNCT
biomedich-293	84	3	e005	e005	PROPN
biomedich-293	84	4	.	.	PUNCT
biomedich-293	84	5	doi	doi	NOUN
biomedich-293	84	6	:	:	PUNCT
biomedich-293	84	7	10.3760	10.3760	NUM
biomedich-293	84	8	/	/	SYM
biomedich-293	84	9	cma.j.cn501120	cma.j.cn501120	NUM
biomedich-293	84	10	-	-	PUNCT
biomedich-293	84	11	20200224	20200224	NUM
biomedich-293	84	12	-	-	PUNCT
biomedich-293	84	13	00088	00088	NUM
biomedich-293	84	14	.	.	PUNCT
biomedich-293	85	1	chu	chu	PROPN
biomedich-293	85	2	h.	h.	PROPN
biomedich-293	85	3	,	,	PUNCT
biomedich-293	85	4	zhou	zhou	PROPN
biomedich-293	85	5	j.	j.	PROPN
biomedich-293	85	6	,	,	PUNCT
biomedich-293	85	7	wong	wong	PROPN
biomedich-293	85	8	b.h.-y	b.h.-y	PROPN
biomedich-293	85	9	.	.	PROPN
biomedich-293	85	10	,	,	PUNCT
biomedich-293	85	11	li	li	PROPN
biomedich-293	85	12	c.	c.	PROPN
biomedich-293	85	13	,	,	PUNCT
biomedich-293	85	14	chan	chan	PROPN
biomedich-293	85	15	j.f.-w	j.f.-w	PROPN
biomedich-293	85	16	.	.	PROPN
biomedich-293	85	17	,	,	PUNCT
biomedich-293	85	18	cheng	cheng	PROPN
biomedich-293	85	19	z.-s	z.-s	PROPN
biomedich-293	85	20	.	.	PUNCT
biomedich-293	85	21	,	,	PUNCT
biomedich-293	85	22	yang	yang	PROPN
biomedich-293	85	23	d.	d.	PROPN
biomedich-293	85	24	,	,	PUNCT
biomedich-293	85	25	wang	wang	PROPN
biomedich-293	85	26	d.	d.	PROPN
biomedich-293	85	27	,	,	PUNCT
biomedich-293	85	28	lee	lee	PROPN
biomedich-293	85	29	a.c.-y	a.c.-y	PROPN
biomedich-293	85	30	.	.	PROPN
biomedich-293	85	31	,	,	PUNCT
biomedich-293	85	32	li	li	PROPN
biomedich-293	85	33	c.	c.	PROPN
biomedich-293	85	34	,	,	PUNCT
biomedich-293	85	35	yeung	yeung	PROPN
biomedich-293	85	36	m.-l	m.-l	PROPN
biomedich-293	85	37	.	.	PUNCT
biomedich-293	85	38	,	,	PUNCT
biomedich-293	85	39	cai	cai	PROPN
biomedich-293	85	40	j.p	j.p	PROPN
biomedich-293	85	41	.	.	PROPN
biomedich-293	85	42	,	,	PUNCT
biomedich-293	85	43	chan	chan	PROPN
biomedich-293	85	44	i.h.-y	i.h.-y	NOUN
biomedich-293	85	45	.	.	PROPN
biomedich-293	85	46	,	,	PUNCT
biomedich-293	85	47	ho	ho	PROPN
biomedich-293	85	48	w.-k	w.-k	PROPN
biomedich-293	85	49	.	.	PUNCT
biomedich-293	85	50	,	,	PUNCT
biomedich-293	85	51	to	to	ADP
biomedich-293	85	52	k.k.-w	k.k.-w	PROPN
biomedich-293	85	53	.	.	PROPN
biomedich-293	85	54	,	,	PUNCT
biomedich-293	85	55	zheng	zheng	PROPN
biomedich-293	85	56	b.-j	b.-j	PROPN
biomedich-293	85	57	.	.	PUNCT
biomedich-293	85	58	,	,	PUNCT
biomedich-293	85	59	yao	yao	PROPN
biomedich-293	85	60	y.	y.	PROPN
biomedich-293	85	61	,	,	PUNCT
biomedich-293	85	62	qin	qin	PROPN
biomedich-293	85	63	c.	c.	PROPN
biomedich-293	85	64	,	,	PUNCT
biomedich-293	85	65	yuen	yuen	PROPN
biomedich-293	85	66	k.-y	k.-y	PROPN
biomedich-293	85	67	.	.	PUNCT
biomedich-293	86	1	(	(	PUNCT
biomedich-293	86	2	2016	2016	NUM
biomedich-293	86	3	)	)	PUNCT
biomedich-293	86	4	middle	middle	PROPN
biomedich-293	86	5	east	east	PROPN
biomedich-293	86	6	respiratory	respiratory	ADJ
biomedich-293	86	7	syndrome	syndrome	NOUN
biomedich-293	86	8	coronavirus	coronavirus	NOUN
biomedich-293	86	9	efficiently	efficiently	ADV
biomedich-293	86	10	infects	infect	VERB
biomedich-293	86	11	human	human	ADJ
biomedich-293	86	12	primary	primary	ADJ
biomedich-293	86	13	t	t	NOUN
biomedich-293	86	14	lymphocytes	lymphocyte	NOUN
biomedich-293	86	15	and	and	CCONJ
biomedich-293	86	16	activates	activate	VERB
biomedich-293	86	17	the	the	DET
biomedich-293	86	18	extrinsic	extrinsic	ADJ
biomedich-293	86	19	and	and	CCONJ
biomedich-293	86	20	intrinsic	intrinsic	ADJ
biomedich-293	86	21	apoptosis	apoptosis	NOUN
biomedich-293	86	22	pathways	pathway	NOUN
biomedich-293	86	23	.	.	PUNCT
biomedich-293	87	1	j.	j.	PROPN
biomedich-293	87	2	infect	infect	PROPN
biomedich-293	87	3	.	.	PUNCT
biomedich-293	88	1	dis	dis	PROPN
biomedich-293	88	2	.	.	PUNCT
biomedich-293	89	1	2016;213:904–914	2016;213:904–914	PROPN
biomedich-293	89	2	.	.	PUNCT
biomedich-293	90	1	doi	doi	NOUN
biomedich-293	90	2	:	:	PUNCT
biomedich-293	90	3	10.1093	10.1093	NUM
biomedich-293	90	4	/	/	SYM
biomedich-293	90	5	infdis	infdis	PROPN
biomedich-293	90	6	/	/	SYM
biomedich-293	90	7	jiv380	jiv380	PROPN
biomedich-293	90	8	.	.	PUNCT
biomedich-293	91	1	conti	conti	PROPN
biomedich-293	91	2	p.	p.	PROPN
biomedich-293	91	3	,	,	PUNCT
biomedich-293	91	4	ronconi	ronconi	PROPN
biomedich-293	91	5	g.	g.	PROPN
biomedich-293	91	6	,	,	PUNCT
biomedich-293	91	7	caraffa	caraffa	PROPN
biomedich-293	91	8	a.	a.	PROPN
biomedich-293	91	9	,	,	PUNCT
biomedich-293	91	10	gallenga	gallenga	PROPN
biomedich-293	91	11	c.	c.	PROPN
biomedich-293	91	12	,	,	PUNCT
biomedich-293	91	13	ross	ross	PROPN
biomedich-293	91	14	r.	r.	PROPN
biomedich-293	91	15	,	,	PUNCT
biomedich-293	91	16	frydas	frydas	PROPN
biomedich-293	91	17	i.	i.	PROPN
biomedich-293	91	18	,	,	PUNCT
biomedich-293	91	19	kritas	kritas	PROPN
biomedich-293	91	20	s.	s.	PROPN
biomedich-293	91	21	(	(	PUNCT
biomedich-293	91	22	2020	2020	NUM
biomedich-293	91	23	)	)	PUNCT
biomedich-293	91	24	induction	induction	NOUN
biomedich-293	91	25	of	of	ADP
biomedich-293	91	26	pro	pro	ADJ
biomedich-293	91	27	-	-	ADJ
biomedich-293	91	28	inflammatory	inflammatory	ADJ
biomedich-293	91	29	cytokines	cytokine	NOUN
biomedich-293	91	30	(	(	PUNCT
biomedich-293	91	31	il1	il1	NOUN
biomedich-293	91	32	and	and	CCONJ
biomedich-293	91	33	il-6	il-6	NUM
biomedich-293	91	34	)	)	PUNCT
biomedich-293	91	35	and	and	CCONJ
biomedich-293	91	36	lung	lung	NOUN
biomedich-293	91	37	inflammation	inflammation	NOUN
biomedich-293	91	38	by	by	ADP
biomedich-293	91	39	coronavirus-19	coronavirus-19	PROPN
biomedich-293	91	40	(	(	PUNCT
biomedich-293	91	41	covi19	covi19	NOUN
biomedich-293	91	42	or	or	CCONJ
biomedich-293	91	43	sars	sar	NOUN
biomedich-293	91	44	-	-	PUNCT
biomedich-293	91	45	cov-2	cov-2	NOUN
biomedich-293	91	46	):	):	PUNCT
biomedich-293	91	47	anti	anti	ADJ
biomedich-293	91	48	-	-	ADJ
biomedich-293	91	49	inflammatory	inflammatory	ADJ
biomedich-293	91	50	strategies	strategy	NOUN
biomedich-293	91	51	.	.	PUNCT
biomedich-293	92	1	j.	j.	PROPN
biomedich-293	92	2	biol	biol	PROPN
biomedich-293	92	3	.	.	PUNCT
biomedich-293	93	1	regul	regul	NOUN
biomedich-293	93	2	.	.	PUNCT
biomedich-293	94	1	homeost	homeost	ADJ
biomedich-293	94	2	.	.	PUNCT
biomedich-293	95	1	agents	agent	NOUN
biomedich-293	95	2	.	.	PUNCT
biomedich-293	96	1	2020;34	2020;34	NUM
biomedich-293	96	2	doi	doi	NOUN
biomedich-293	96	3	:	:	PUNCT
biomedich-293	96	4	10.23812	10.23812	NUM
biomedich-293	96	5	/	/	SYM
biomedich-293	96	6	conti	conti	NOUN
biomedich-293	96	7	-	-	PROPN
biomedich-293	96	8	e.	e.	PROPN
biomedich-293	96	9	c.y	c.y	PROPN
biomedich-293	96	10	.	.	PROPN
biomedich-293	96	11	,	,	PUNCT
biomedich-293	96	12	poon	poon	NOUN
biomedich-293	96	13	l.l.m	l.l.m	NOUN
biomedich-293	96	14	.	.	PUNCT
biomedich-293	96	15	,	,	PUNCT
biomedich-293	96	16	ng	ng	PROPN
biomedich-293	96	17	i.h.y	i.h.y	PROPN
biomedich-293	96	18	.	.	PUNCT
biomedich-293	96	19	,	,	PUNCT
biomedich-293	96	20	luk	luk	PROPN
biomedich-293	96	21	w.	w.	PROPN
biomedich-293	96	22	,	,	PUNCT
biomedich-293	96	23	sia	sia	PROPN
biomedich-293	96	24	s.-f	s.-f	PROPN
biomedich-293	96	25	.	.	PUNCT
biomedich-293	96	26	,	,	PUNCT
biomedich-293	96	27	wu	wu	PROPN
biomedich-293	96	28	m.h.s	m.h.s	PROPN
biomedich-293	96	29	.	.	PROPN
biomedich-293	96	30	,	,	PUNCT
biomedich-293	96	31	chan	chan	PROPN
biomedich-293	96	32	k.-h	k.-h	PROPN
biomedich-293	96	33	.	.	PUNCT
biomedich-293	96	34	,	,	PUNCT
biomedich-293	96	35	yuen	yuen	PROPN
biomedich-293	96	36	k.-y	k.-y	PROPN
biomedich-293	96	37	.	.	PUNCT
biomedich-293	96	38	,	,	PUNCT
biomedich-293	96	39	gordon	gordon	PROPN
biomedich-293	96	40	s.	s.	PROPN
biomedich-293	96	41	,	,	PUNCT
biomedich-293	96	42	guan	guan	PROPN
biomedich-293	96	43	y.	y.	PROPN
biomedich-293	96	44	,	,	PUNCT
biomedich-293	96	45	peiris	peiris	PROPN
biomedich-293	96	46	j.s.m	j.s.m	PROPN
biomedich-293	96	47	.	.	PUNCT
biomedich-293	96	48	(	(	PUNCT
biomedich-293	96	49	2005	2005	NUM
biomedich-293	96	50	)	)	PUNCT
biomedich-293	96	51	cytokine	cytokine	NOUN
biomedich-293	96	52	responses	response	NOUN
biomedich-293	96	53	in	in	ADP
biomedich-293	96	54	severe	severe	ADJ
biomedich-293	96	55	acute	acute	ADJ
biomedich-293	96	56	respiratory	respiratory	ADJ
biomedich-293	96	57	syndrome	syndrome	NOUN
biomedich-293	96	58	coronavirus	coronavirus	NOUN
biomedich-293	96	59	-	-	PUNCT
biomedich-293	96	60	infected	infect	VERB
biomedich-293	96	61	macrophages	macrophage	NOUN
biomedich-293	96	62	in	in	ADP
biomedich-293	96	63	vitro	vitro	VERB
biomedich-293	96	64	:	:	PUNCT
biomedich-293	96	65	possible	possible	ADJ
biomedich-293	96	66	relevance	relevance	NOUN
biomedich-293	96	67	to	to	ADP
biomedich-293	96	68	pathogenesis	pathogenesis	NOUN
biomedich-293	96	69	.	.	PUNCT
biomedich-293	97	1	j.	j.	PROPN
biomedich-293	97	2	virol	virol	PROPN
biomedich-293	97	3	.	.	PUNCT
biomedich-293	98	1	2005;79:7819–7826	2005;79:7819–7826	NOUN
biomedich-293	98	2	.	.	PUNCT
biomedich-293	99	1	doi	doi	NOUN
biomedich-293	99	2	:	:	PUNCT
biomedich-293	99	3	10.1128	10.1128	NUM
biomedich-293	99	4	/	/	SYM
biomedich-293	99	5	jvi.79.12.7819	jvi.79.12.7819	NOUN
biomedich-293	99	6	-	-	PUNCT
biomedich-293	99	7	7826.2005	7826.2005	NOUN
biomedich-293	99	8	.	.	PUNCT
biomedich-293	100	1	dediego	dediego	PROPN
biomedich-293	100	2	m.l	m.l	PROPN
biomedich-293	100	3	.	.	PROPN
biomedich-293	100	4	,	,	PUNCT
biomedich-293	100	5	nieto	nieto	PROPN
biomedich-293	100	6	-	-	PUNCT
biomedich-293	100	7	torres	torre	VERB
biomedich-293	100	8	j.l	j.l	PROPN
biomedich-293	100	9	.	.	PROPN
biomedich-293	100	10	,	,	PUNCT
biomedich-293	100	11	regla	regla	PROPN
biomedich-293	100	12	-	-	PUNCT
biomedich-293	100	13	nava	nava	PROPN
biomedich-293	100	14	j.a	j.a	PROPN
biomedich-293	100	15	.	.	PROPN
biomedich-293	100	16	,	,	PUNCT
biomedich-293	100	17	jimenezguardeño	jimenezguardeño	PROPN
biomedich-293	100	18	j.m	j.m	PROPN
biomedich-293	100	19	.	.	PROPN
biomedich-293	100	20	,	,	PUNCT
biomedich-293	100	21	fernandez	fernandez	PROPN
biomedich-293	100	22	-	-	PUNCT
biomedich-293	100	23	delgado	delgado	PROPN
biomedich-293	100	24	r.	r.	PROPN
biomedich-293	100	25	,	,	PUNCT
biomedich-293	100	26	fett	fett	PROPN
biomedich-293	100	27	c.	c.	PROPN
biomedich-293	100	28	,	,	PUNCT
biomedich-293	100	29	castañorodriguez	castañorodriguez	PROPN
biomedich-293	100	30	c.	c.	PROPN
biomedich-293	100	31	,	,	PUNCT
biomedich-293	100	32	perlman	perlman	PROPN
biomedich-293	100	33	s.	s.	PROPN
biomedich-293	100	34	,	,	PUNCT
biomedich-293	100	35	enjuanes	enjuanes	PROPN
biomedich-293	100	36	l.	l.	PROPN
biomedich-293	100	37	(	(	PUNCT
biomedich-293	100	38	2014	2014	NUM
biomedich-293	100	39	)	)	PUNCT
biomedich-293	100	40	inhibition	inhibition	NOUN
biomedich-293	100	41	of	of	ADP
biomedich-293	100	42	nf	nf	ADJ
biomedich-293	100	43	-	-	PUNCT
biomedich-293	100	44	κb	κb	NOUN
biomedich-293	100	45	-	-	PUNCT
biomedich-293	100	46	mediated	mediate	VERB
biomedich-293	100	47	inflammation	inflammation	NOUN
biomedich-293	100	48	in	in	ADP
biomedich-293	100	49	severe	severe	ADJ
biomedich-293	100	50	acute	acute	ADJ
biomedich-293	100	51	respiratory	respiratory	ADJ
biomedich-293	100	52	syndrome	syndrome	NOUN
biomedich-293	100	53	coronavirus	coronavirus	NOUN
biomedich-293	100	54	-	-	PUNCT
biomedich-293	100	55	infected	infect	VERB
biomedich-293	100	56	mice	mice	NOUN
biomedich-293	100	57	increases	increase	VERB
biomedich-293	100	58	survival	survival	NOUN
biomedich-293	100	59	.	.	PUNCT
biomedich-293	101	1	j.	j.	PROPN
biomedich-293	101	2	virol	virol	PROPN
biomedich-293	101	3	.	.	PUNCT
biomedich-293	102	1	2014;88:913–924	2014;88:913–924	X
biomedich-293	102	2	.	.	PUNCT
biomedich-293	103	1	doi	doi	NOUN
biomedich-293	103	2	:	:	PUNCT
biomedich-293	103	3	10.1128	10.1128	NUM
biomedich-293	103	4	/	/	SYM
biomedich-293	103	5	jvi.02576	jvi.02576	PROPN
biomedich-293	103	6	-	-	SYM
biomedich-293	103	7	13	13	NUM
biomedich-293	103	8	.	.	PUNCT
biomedich-293	104	1	etti	etti	PROPN
biomedich-293	104	2	,	,	PUNCT
biomedich-293	104	3	azulay	azulay	NOUN
biomedich-293	104	4	e	e	NOUN
biomedich-293	104	5	;	;	PUNCT
biomedich-293	104	6	assy	assy	ADJ
biomedich-293	104	7	,	,	PUNCT
biomedich-293	104	8	nimer	nimer	NOUN
biomedich-293	104	9	;	;	PUNCT
biomedich-293	104	10	and	and	CCONJ
biomedich-293	104	11	idan	idan	PROPN
biomedich-293	104	12	,	,	PUNCT
biomedich-293	104	13	cohen	cohen	PROPN
biomedich-293	104	14	(	(	PUNCT
biomedich-293	104	15	2018	2018	NUM
biomedich-293	104	16	)	)	PUNCT
biomedich-293	104	17	interleukin1	interleukin1	NOUN
biomedich-293	104	18	.	.	PUNCT
biomedich-293	105	1	in	in	ADP
biomedich-293	105	2	:	:	PUNCT
biomedich-293	105	3	els	el	NOUN
biomedich-293	105	4	.	.	PUNCT
biomedich-293	106	1	john	john	PROPN
biomedich-293	106	2	wiley	wiley	PROPN
biomedich-293	106	3	&	&	CCONJ
biomedich-293	106	4	sons	sons	PROPN
biomedich-293	106	5	,	,	PUNCT
biomedich-293	106	6	ltd	ltd	PROPN
biomedich-293	106	7	:	:	PUNCT
biomedich-293	106	8	chichester.doi	chichester.doi	X
biomedich-293	106	9	:	:	PUNCT
biomedich-293	106	10	10.1002/9780470015902.a0028193	10.1002/9780470015902.a0028193	NUM
biomedich-293	106	11	hui	hui	PROPN
biomedich-293	106	12	d.s.c	d.s.c	PROPN
biomedich-293	106	13	.	.	PROPN
biomedich-293	106	14	,	,	PUNCT
biomedich-293	106	15	zumla	zumla	PROPN
biomedich-293	106	16	a.	a.	NOUN
biomedich-293	106	17	(	(	PUNCT
biomedich-293	106	18	2019	2019	NUM
biomedich-293	106	19	)	)	PUNCT
biomedich-293	106	20	severe	severe	ADJ
biomedich-293	106	21	acute	acute	ADJ
biomedich-293	106	22	respiratory	respiratory	ADJ
biomedich-293	106	23	syndrome	syndrome	NOUN
biomedich-293	106	24	:	:	PUNCT
biomedich-293	106	25	historical	historical	ADJ
biomedich-293	106	26	,	,	PUNCT
biomedich-293	106	27	epidemiologic	epidemiologic	ADJ
biomedich-293	106	28	,	,	PUNCT
biomedich-293	106	29	and	and	CCONJ
biomedich-293	106	30	clinical	clinical	ADJ
biomedich-293	106	31	features	feature	NOUN
biomedich-293	106	32	.	.	PUNCT
biomedich-293	107	1	infect	infect	VERB
biomedich-293	107	2	.	.	PUNCT
biomedich-293	108	1	dis	dis	PROPN
biomedich-293	108	2	.	.	PUNCT
biomedich-293	109	1	clin	clin	PROPN
biomedich-293	109	2	.	.	PUNCT
biomedich-293	110	1	north	north	PROPN
biomedich-293	110	2	am	am	PROPN
biomedich-293	110	3	.	.	PUNCT
biomedich-293	111	1	2019;33:869–889	2019;33:869–889	NOUN
biomedich-293	111	2	.	.	PUNCT
biomedich-293	112	1	doi	doi	NOUN
biomedich-293	112	2	:	:	PUNCT
biomedich-293	112	3	10.1016	10.1016	NUM
biomedich-293	112	4	/	/	SYM
biomedich-293	112	5	j.idc.2019.07.001	j.idc.2019.07.001	PROPN
biomedich-293	112	6	.	.	PUNCT
biomedich-293	113	1	kritas	kritas	PROPN
biomedich-293	113	2	s.k	s.k	PROPN
biomedich-293	113	3	.	.	PROPN
biomedich-293	113	4	,	,	PUNCT
biomedich-293	113	5	ronconi	ronconi	PROPN
biomedich-293	113	6	g.	g.	PROPN
biomedich-293	113	7	,	,	PUNCT
biomedich-293	113	8	caraffa	caraffa	PROPN
biomedich-293	113	9	a.	a.	PROPN
biomedich-293	113	10	,	,	PUNCT
biomedich-293	113	11	gallenga	gallenga	PROPN
biomedich-293	113	12	c.e	c.e	PROPN
biomedich-293	113	13	.	.	PROPN
biomedich-293	113	14	,	,	PUNCT
biomedich-293	113	15	ross	ross	PROPN
biomedich-293	113	16	r.	r.	PROPN
biomedich-293	113	17	,	,	PUNCT
biomedich-293	113	18	conti	conti	PROPN
biomedich-293	113	19	p.	p.	PROPN
biomedich-293	113	20	(	(	PUNCT
biomedich-293	113	21	2020	2020	NUM
biomedich-293	113	22	)	)	PUNCT
biomedich-293	113	23	mast	mast	NOUN
biomedich-293	113	24	cells	cell	NOUN
biomedich-293	113	25	contribute	contribute	VERB
biomedich-293	113	26	to	to	ADP
biomedich-293	113	27	coronavirus	coronavirus	NOUN
biomedich-293	113	28	-	-	PUNCT
biomedich-293	113	29	induced	induce	VERB
biomedich-293	113	30	inflammation	inflammation	NOUN
biomedich-293	113	31	:	:	PUNCT
biomedich-293	113	32	new	new	ADJ
biomedich-293	113	33	anti	anti	ADJ
biomedich-293	113	34	-	-	ADJ
biomedich-293	113	35	inflammatory	inflammatory	ADJ
biomedich-293	113	36	strategy	strategy	NOUN
biomedich-293	113	37	.	.	PUNCT
biomedich-293	114	1	j.	j.	PROPN
biomedich-293	114	2	biol	biol	PROPN
biomedich-293	114	3	.	.	PUNCT
biomedich-293	115	1	regul	regul	NOUN
biomedich-293	115	2	.	.	PUNCT
biomedich-293	116	1	homeost	homeost	ADJ
biomedich-293	116	2	.	.	PUNCT
biomedich-293	117	1	agents	agent	NOUN
biomedich-293	117	2	.	.	PUNCT
biomedich-293	118	1	2020;34	2020;34	NUM
biomedich-293	118	2	doi	doi	NOUN
biomedich-293	118	3	:	:	PUNCT
biomedich-293	118	4	10.23812/20	10.23812/20	NUM
biomedich-293	118	5	-	-	ADJ
biomedich-293	118	6	editorial	editorial	ADJ
biomedich-293	118	7	-	-	PUNCT
biomedich-293	118	8	kritas	krita	NOUN
biomedich-293	118	9	.	.	PUNCT
biomedich-293	119	1	law	law	NOUN
biomedich-293	119	2	h.k.w	h.k.w	NOUN
biomedich-293	119	3	.	.	PUNCT
biomedich-293	119	4	,	,	PUNCT
biomedich-293	120	1	cheung	cheung	PROPN
biomedich-293	120	2	c.y	c.y	PROPN
biomedich-293	120	3	.	.	PROPN
biomedich-293	120	4	,	,	PUNCT
biomedich-293	120	5	ng	ng	PROPN
biomedich-293	120	6	h.y	h.y	PROPN
biomedich-293	120	7	.	.	PROPN
biomedich-293	120	8	,	,	PUNCT
biomedich-293	120	9	sia	sia	PROPN
biomedich-293	120	10	s.f	s.f	PROPN
biomedich-293	120	11	.	.	PROPN
biomedich-293	120	12	,	,	PUNCT
biomedich-293	120	13	chan	chan	PROPN
biomedich-293	120	14	y.o	y.o	PROPN
biomedich-293	120	15	.	.	PROPN
biomedich-293	120	16	,	,	PUNCT
biomedich-293	120	17	luk	luk	PROPN
biomedich-293	120	18	w.	w.	PROPN
biomedich-293	120	19	,	,	PUNCT
biomedich-293	120	20	nicholls	nicholls	PROPN
biomedich-293	120	21	j.m	j.m	PROPN
biomedich-293	120	22	.	.	PROPN
biomedich-293	120	23	,	,	PUNCT
biomedich-293	120	24	peiris	peiris	PROPN
biomedich-293	120	25	j.s.m	j.s.m	PROPN
biomedich-293	120	26	.	.	PROPN
biomedich-293	120	27	,	,	PUNCT
biomedich-293	120	28	lau	lau	PROPN
biomedich-293	120	29	y.l	y.l	PROPN
biomedich-293	120	30	.	.	PROPN
biomedich-293	121	1	(	(	PUNCT
biomedich-293	121	2	2005	2005	NUM
biomedich-293	121	3	)	)	PUNCT
biomedich-293	121	4	chemokine	chemokine	ADJ
biomedich-293	121	5	up	up	ADJ
biomedich-293	121	6	-	-	PUNCT
biomedich-293	121	7	regulation	regulation	NOUN
biomedich-293	121	8	in	in	ADP
biomedich-293	121	9	sars	sar	NOUN
biomedich-293	121	10	-	-	PUNCT
biomedich-293	121	11	coronavirus	coronavirus	NOUN
biomedich-293	121	12	–	–	PUNCT
biomedich-293	121	13	infected	infected	ADJ
biomedich-293	121	14	,	,	PUNCT
biomedich-293	121	15	monocytederived	monocytederive	VERB
biomedich-293	121	16	human	human	ADJ
biomedich-293	121	17	dendritic	dendritic	ADJ
biomedich-293	121	18	cells	cell	NOUN
biomedich-293	121	19	.	.	PUNCT
biomedich-293	122	1	blood	blood	NOUN
biomedich-293	122	2	.	.	PUNCT
biomedich-293	123	1	2005;106:2366–2374	2005;106:2366–2374	NUM
biomedich-293	123	2	.	.	PUNCT
biomedich-293	124	1	doi	doi	NOUN
biomedich-293	124	2	:	:	PUNCT
biomedich-293	124	3	10.1182	10.1182	NUM
biomedich-293	124	4	/	/	SYM
biomedich-293	124	5	blood-2004	blood-2004	NOUN
biomedich-293	124	6	-	-	PUNCT
biomedich-293	124	7	10	10	NUM
biomedich-293	124	8	-	-	PUNCT
biomedich-293	124	9	4166	4166	NUM
biomedich-293	124	10	.	.	PUNCT
biomedich-293	125	1	mehta	mehta	PROPN
biomedich-293	125	2	p.	p.	PROPN
biomedich-293	125	3	,	,	PUNCT
biomedich-293	125	4	mcauley	mcauley	PROPN
biomedich-293	125	5	d.f	d.f	PROPN
biomedich-293	125	6	.	.	PROPN
biomedich-293	125	7	,	,	PUNCT
biomedich-293	125	8	brown	brown	ADJ
biomedich-293	125	9	m.	m.	NOUN
biomedich-293	125	10	,	,	PUNCT
biomedich-293	125	11	sanchez	sanchez	PROPN
biomedich-293	125	12	e.	e.	PROPN
biomedich-293	125	13	,	,	PUNCT
biomedich-293	125	14	tattersall	tattersall	PROPN
biomedich-293	125	15	r.s	r.s	PROPN
biomedich-293	125	16	.	.	PROPN
biomedich-293	125	17	,	,	PUNCT
biomedich-293	125	18	manson	manson	PROPN
biomedich-293	125	19	j.j	j.j	PROPN
biomedich-293	125	20	.	.	PROPN
biomedich-293	125	21	(	(	PUNCT
biomedich-293	125	22	2020	2020	NUM
biomedich-293	125	23	)	)	PUNCT
biomedich-293	125	24	hlh	hlh	NOUN
biomedich-293	125	25	across	across	ADP
biomedich-293	125	26	speciality	speciality	NOUN
biomedich-293	125	27	collaboration	collaboration	NOUN
biomedich-293	125	28	,	,	PUNCT
biomedich-293	125	29	uk	uk	PROPN
biomedich-293	125	30	,	,	PUNCT
biomedich-293	125	31	covid-19	covid-19	PROPN
biomedich-293	125	32	:	:	PUNCT
biomedich-293	125	33	consider	consider	VERB
biomedich-293	125	34	cytokine	cytokine	ADJ
biomedich-293	125	35	storm	storm	NOUN
biomedich-293	125	36	syndromes	syndrome	NOUN
biomedich-293	125	37	and	and	CCONJ
biomedich-293	125	38	immunosuppression	immunosuppression	NOUN
biomedich-293	125	39	.	.	PUNCT
biomedich-293	126	1	lancet	lancet	NOUN
biomedich-293	126	2	.	.	PUNCT
biomedich-293	127	1	2020;395:1033–1034	2020;395:1033–1034	X
biomedich-293	127	2	.	.	PUNCT
biomedich-293	128	1	doi	doi	NOUN
biomedich-293	128	2	:	:	PUNCT
biomedich-293	128	3	10.1016	10.1016	NUM
biomedich-293	128	4	/	/	SYM
biomedich-293	128	5	s0140	s0140	PROPN
biomedich-293	128	6	-	-	PUNCT
biomedich-293	128	7	6736(20)30628	6736(20)30628	NUM
biomedich-293	128	8	-	-	PUNCT
biomedich-293	128	9	0	0	NUM
biomedich-293	128	10	.	.	PUNCT
biomedich-293	129	1	liu	liu	PROPN
biomedich-293	129	2	y.	y.	PROPN
biomedich-293	129	3	,	,	PUNCT
biomedich-293	129	4	zhang	zhang	PROPN
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biomedich-293	129	6	,	,	PUNCT
biomedich-293	129	7	huang	huang	PROPN
biomedich-293	129	8	f.	f.	PROPN
biomedich-293	129	9	,	,	PUNCT
biomedich-293	129	10	yang	yang	PROPN
biomedich-293	129	11	y.	y.	PROPN
biomedich-293	129	12	,	,	PUNCT
biomedich-293	129	13	wang	wang	PROPN
biomedich-293	129	14	f.	f.	PROPN
biomedich-293	129	15	,	,	PUNCT
biomedich-293	129	16	yuan	yuan	PROPN
biomedich-293	129	17	j.	j.	PROPN
biomedich-293	129	18	,	,	PUNCT
biomedich-293	129	19	zhang	zhang	PROPN
biomedich-293	129	20	z.	z.	PROPN
biomedich-293	129	21	,	,	PUNCT
biomedich-293	129	22	qin	qin	PROPN
biomedich-293	129	23	y.	y.	PROPN
biomedich-293	129	24	,	,	PUNCT
biomedich-293	129	25	li	li	PROPN
biomedich-293	129	26	x.	x.	PROPN
biomedich-293	129	27	,	,	PUNCT
biomedich-293	129	28	zhao	zhao	PROPN
biomedich-293	129	29	d.	d.	PROPN
biomedich-293	129	30	,	,	PUNCT
biomedich-293	129	31	li	li	PROPN
biomedich-293	129	32	s.	s.	PROPN
biomedich-293	129	33	,	,	PUNCT
biomedich-293	129	34	tan	tan	PROPN
biomedich-293	129	35	s.	s.	PROPN
biomedich-293	129	36	,	,	PUNCT
biomedich-293	129	37	wang	wang	PROPN
biomedich-293	129	38	z.	z.	PROPN
biomedich-293	129	39	,	,	PUNCT
biomedich-293	129	40	li	li	PROPN
biomedich-293	129	41	j.	j.	PROPN
biomedich-293	129	42	,	,	PUNCT
biomedich-293	129	43	shen	shen	PROPN
biomedich-293	129	44	c.	c.	PROPN
biomedich-293	129	45	,	,	PUNCT
biomedich-293	129	46	li	li	PROPN
biomedich-293	129	47	j.	j.	PROPN
biomedich-293	129	48	,	,	PUNCT
biomedich-293	129	49	peng	peng	PROPN
biomedich-293	129	50	l.	l.	PROPN
biomedich-293	129	51	,	,	PUNCT
biomedich-293	129	52	wu	wu	PROPN
biomedich-293	129	53	w.	w.	PROPN
biomedich-293	129	54	,	,	PUNCT
biomedich-293	129	55	cao	cao	PROPN
biomedich-293	129	56	m.	m.	PROPN
biomedich-293	129	57	,	,	PUNCT
biomedich-293	129	58	xing	xing	PROPN
biomedich-293	129	59	l.	l.	PROPN
biomedich-293	129	60	,	,	PUNCT
biomedich-293	129	61	xu	xu	PROPN
biomedich-293	129	62	z.	z.	PROPN
biomedich-293	129	63	,	,	PUNCT
biomedich-293	129	64	chen	chen	PROPN
biomedich-293	129	65	l.	l.	PROPN
biomedich-293	129	66	,	,	PUNCT
biomedich-293	129	67	zhou	zhou	PROPN
biomedich-293	129	68	c.	c.	PROPN
biomedich-293	129	69	,	,	PUNCT
biomedich-293	129	70	liu	liu	PROPN
biomedich-293	129	71	w.j	w.j	PROPN
biomedich-293	129	72	.	.	PROPN
biomedich-293	129	73	,	,	PUNCT
biomedich-293	129	74	liu	liu	PROPN
biomedich-293	129	75	l.	l.	PROPN
biomedich-293	129	76	,	,	PUNCT
biomedich-293	129	77	jiang	jiang	PROPN
biomedich-293	129	78	c.	c.	PROPN
biomedich-293	129	79	(	(	PUNCT
biomedich-293	129	80	2020	2020	NUM
biomedich-293	129	81	)	)	PUNCT
biomedich-293	129	82	2019	2019	NUM
biomedich-293	129	83	-	-	PUNCT
biomedich-293	129	84	novel	novel	NOUN
biomedich-293	129	85	coronavirus	coronavirus	NOUN
biomedich-293	129	86	(	(	PUNCT
biomedich-293	129	87	2019	2019	NUM
biomedich-293	129	88	-	-	PUNCT
biomedich-293	129	89	ncov	ncov	NOUN
biomedich-293	129	90	)	)	PUNCT
biomedich-293	129	91	infections	infection	NOUN
biomedich-293	129	92	trigger	trigger	VERB
biomedich-293	129	93	an	an	DET
biomedich-293	129	94	exaggerated	exaggerated	ADJ
biomedich-293	129	95	cytokine	cytokine	ADJ
biomedich-293	129	96	response	response	NOUN
biomedich-293	129	97	aggravating	aggravate	VERB
biomedich-293	129	98	lung	lung	NOUN
biomedich-293	129	99	injury	injury	NOUN
biomedich-293	129	100	.	.	PUNCT
biomedich-293	130	1	nieto	nieto	PROPN
biomedich-293	130	2	-	-	PUNCT
biomedich-293	130	3	torres	torres	PROPN
biomedich-293	130	4	j.l	j.l	PROPN
biomedich-293	130	5	.	.	PROPN
biomedich-293	130	6	,	,	PUNCT
biomedich-293	130	7	dediego	dediego	PROPN
biomedich-293	130	8	m.l	m.l	PROPN
biomedich-293	130	9	.	.	PROPN
biomedich-293	130	10	,	,	PUNCT
biomedich-293	130	11	verdiá	verdiá	PROPN
biomedich-293	130	12	-	-	PUNCT
biomedich-293	130	13	báguena	báguena	ADJ
biomedich-293	130	14	c.	c.	PROPN
biomedich-293	130	15	,	,	PUNCT
biomedich-293	130	16	jimenezguardeño	jimenezguardeño	PROPN
biomedich-293	130	17	j.m	j.m	PROPN
biomedich-293	130	18	.	.	PROPN
biomedich-293	130	19	,	,	PUNCT
biomedich-293	130	20	regla	regla	PROPN
biomedich-293	130	21	-	-	PUNCT
biomedich-293	130	22	nava	nava	PROPN
biomedich-293	130	23	j.a	j.a	PROPN
biomedich-293	130	24	.	.	PROPN
biomedich-293	130	25	,	,	PUNCT
biomedich-293	130	26	fernandez	fernandez	PROPN
biomedich-293	130	27	-	-	PUNCT
biomedich-293	130	28	delgado	delgado	PROPN
biomedich-293	130	29	r.	r.	PROPN
biomedich-293	130	30	,	,	PUNCT
biomedich-293	130	31	castaño	castaño	NOUN
biomedich-293	130	32	-	-	PUNCT
biomedich-293	130	33	rodriguez	rodriguez	PROPN
biomedich-293	130	34	c.	c.	PROPN
biomedich-293	130	35	,	,	PUNCT
biomedich-293	130	36	alcaraz	alcaraz	PROPN
biomedich-293	130	37	a.	a.	NOUN
biomedich-293	130	38	,	,	PUNCT
biomedich-293	130	39	torres	torre	VERB
biomedich-293	130	40	j.	j.	PROPN
biomedich-293	130	41	,	,	PUNCT
biomedich-293	130	42	aguilella	aguilella	PROPN
biomedich-293	130	43	v.m	v.m	PROPN
biomedich-293	130	44	.	.	PROPN
biomedich-293	130	45	,	,	PUNCT
biomedich-293	130	46	enjuanes	enjuanes	PROPN
biomedich-293	130	47	l.	l.	PROPN
biomedich-293	130	48	(	(	PUNCT
biomedich-293	130	49	2014	2014	NUM
biomedich-293	130	50	)	)	PUNCT
biomedich-293	130	51	severe	severe	ADJ
biomedich-293	130	52	acute	acute	ADJ
biomedich-293	130	53	respiratory	respiratory	ADJ
biomedich-293	130	54	syndrome	syndrome	NOUN
biomedich-293	130	55	coronavirus	coronavirus	NOUN
biomedich-293	130	56	envelope	envelope	NOUN
biomedich-293	130	57	protein	protein	NOUN
biomedich-293	130	58	ion	ion	NOUN
biomedich-293	130	59	channel	channel	NOUN
biomedich-293	130	60	activity	activity	NOUN
biomedich-293	130	61	promotes	promote	VERB
biomedich-293	130	62	virus	virus	NOUN
biomedich-293	130	63	fitness	fitness	NOUN
biomedich-293	130	64	and	and	CCONJ
biomedich-293	130	65	pathogenesis	pathogenesis	NOUN
biomedich-293	130	66	.	.	PUNCT
biomedich-293	131	1	plos	plos	PROPN
biomedich-293	131	2	pathog	pathog	PROPN
biomedich-293	131	3	.	.	PUNCT
biomedich-293	132	1	2014;10	2014;10	NUM
biomedich-293	132	2	:	:	PUNCT
biomedich-293	132	3	e1004077	e1004077	PROPN
biomedich-293	132	4	.	.	PUNCT
biomedich-293	132	5	doi	doi	PROPN
biomedich-293	132	6	:	:	PUNCT
biomedich-293	132	7	10.1371	10.1371	NUM
biomedich-293	132	8	/	/	SYM
biomedich-293	132	9	journal.ppat.1004077	journal.ppat.1004077	PROPN
biomedich-293	132	10	.	.	PUNCT
biomedich-293	132	11	qin	qin	PROPN
biomedich-293	132	12	c.	c.	PROPN
biomedich-293	132	13	,	,	PUNCT
biomedich-293	132	14	zhou	zhou	PROPN
biomedich-293	132	15	l.	l.	PROPN
biomedich-293	132	16	,	,	PUNCT
biomedich-293	132	17	hu	hu	PROPN
biomedich-293	132	18	z.	z.	PROPN
biomedich-293	132	19	,	,	PUNCT
biomedich-293	132	20	zhang	zhang	PROPN
biomedich-293	132	21	s.	s.	PROPN
biomedich-293	132	22	,	,	PUNCT
biomedich-293	132	23	yang	yang	PROPN
biomedich-293	132	24	s.	s.	PROPN
biomedich-293	132	25	,	,	PUNCT
biomedich-293	132	26	tao	tao	PROPN
biomedich-293	132	27	y.	y.	PROPN
biomedich-293	132	28	,	,	PUNCT
biomedich-293	132	29	xie	xie	PROPN
biomedich-293	132	30	c.	c.	PROPN
biomedich-293	132	31	,	,	PUNCT
biomedich-293	132	32	ma	ma	PROPN
biomedich-293	132	33	k.	k.	PROPN
biomedich-293	132	34	,	,	PUNCT
biomedich-293	132	35	shang	shang	PROPN
biomedich-293	132	36	k.	k.	PROPN
biomedich-293	132	37	,	,	PUNCT
biomedich-293	132	38	wang	wang	PROPN
biomedich-293	132	39	w.	w.	PROPN
biomedich-293	132	40	,	,	PUNCT
biomedich-293	132	41	tian	tian	ADJ
biomedich-293	132	42	d.-s	d.-	NOUN
biomedich-293	132	43	.	.	PUNCT
biomedich-293	133	1	(	(	PUNCT
biomedich-293	133	2	2020	2020	NUM
biomedich-293	133	3	)	)	PUNCT
biomedich-293	133	4	dysregulation	dysregulation	NOUN
biomedich-293	133	5	of	of	ADP
biomedich-293	133	6	immune	immune	ADJ
biomedich-293	133	7	response	response	NOUN
biomedich-293	133	8	in	in	ADP
biomedich-293	133	9	patients	patient	NOUN
biomedich-293	133	10	with	with	ADP
biomedich-293	133	11	covid-19	covid-19	PROPN
biomedich-293	133	12	in	in	ADP
biomedich-293	133	13	wuhan	wuhan	PROPN
biomedich-293	133	14	,	,	PUNCT
biomedich-293	133	15	china	china	PROPN
biomedich-293	133	16	.	.	PUNCT
biomedich-293	134	1	clin	clin	PROPN
biomedich-293	134	2	.	.	PUNCT
biomedich-293	135	1	infect	infect	VERB
biomedich-293	135	2	.	.	PUNCT
biomedich-293	136	1	dis	dis	PROPN
biomedich-293	136	2	.	.	PUNCT
biomedich-293	137	1	2020	2020	NUM
biomedich-293	137	2	doi	doi	NOUN
biomedich-293	137	3	:	:	PUNCT
biomedich-293	137	4	10.1093	10.1093	NUM
biomedich-293	137	5	/	/	SYM
biomedich-293	137	6	cid	cid	NOUN
biomedich-293	137	7	/	/	SYM
biomedich-293	137	8	ciaa248	ciaa248	PROPN
biomedich-293	137	9	.	.	PUNCT
biomedich-293	138	1	siu	siu	PROPN
biomedich-293	138	2	k.-l	k.-l	PROPN
biomedich-293	138	3	.	.	PUNCT
biomedich-293	138	4	,	,	PUNCT
biomedich-293	138	5	yuen	yuen	PROPN
biomedich-293	138	6	k.-s	k.-s	PROPN
biomedich-293	138	7	.	.	PROPN
biomedich-293	138	8	,	,	PUNCT
biomedich-293	138	9	castaño	castaño	PROPN
biomedich-293	138	10	-	-	PUNCT
biomedich-293	138	11	rodriguez	rodriguez	PROPN
biomedich-293	138	12	c.	c.	NOUN
biomedich-293	138	13	,	,	PUNCT
biomedich-293	138	14	ye	ye	PROPN
biomedich-293	138	15	z.-w	z.-w	NOUN
biomedich-293	138	16	.	.	PUNCT
biomedich-293	138	17	,	,	PUNCT
biomedich-293	138	18	yeung	yeung	PROPN
biomedich-293	138	19	m.-l	m.-l	PROPN
biomedich-293	138	20	.	.	PUNCT
biomedich-293	138	21	,	,	PUNCT
biomedich-293	138	22	fung	fung	PROPN
biomedich-293	138	23	s.-y	s.-y	PROPN
biomedich-293	138	24	.	.	PUNCT
biomedich-293	138	25	,	,	PUNCT
biomedich-293	138	26	yuan	yuan	PROPN
biomedich-293	138	27	s.	s.	PROPN
biomedich-293	138	28	,	,	PUNCT
biomedich-293	138	29	chan	chan	PROPN
biomedich-293	138	30	c.-p	c.-p	PROPN
biomedich-293	138	31	.	.	PROPN
biomedich-293	138	32	,	,	PUNCT
biomedich-293	138	33	yuen	yuen	PROPN
biomedich-293	138	34	k.-y	k.-y	PROPN
biomedich-293	138	35	.	.	PUNCT
biomedich-293	138	36	,	,	PUNCT
biomedich-293	138	37	enjuanes	enjuanes	PROPN
biomedich-293	138	38	l.	l.	PROPN
biomedich-293	138	39	,	,	PUNCT
biomedich-293	138	40	jin	jin	PROPN
biomedich-293	138	41	d.-y	d.-y	PROPN
biomedich-293	138	42	.	.	PUNCT
biomedich-293	139	1	(	(	PUNCT
biomedich-293	139	2	2019	2019	NUM
biomedich-293	139	3	)	)	PUNCT
biomedich-293	139	4	severe	severe	ADJ
biomedich-293	139	5	acute	acute	ADJ
biomedich-293	139	6	respiratory	respiratory	ADJ
biomedich-293	139	7	syndrome	syndrome	NOUN
biomedich-293	139	8	coronavirus	coronavirus	NOUN
biomedich-293	139	9	orf3a	orf3a	NOUN
biomedich-293	139	10	protein	protein	NOUN
biomedich-293	139	11	activates	activate	VERB
biomedich-293	139	12	the	the	DET
biomedich-293	139	13	nlrp3	nlrp3	ADJ
biomedich-293	139	14	inflammasome	inflammasome	NOUN
biomedich-293	139	15	by	by	ADP
biomedich-293	139	16	promoting	promote	VERB
biomedich-293	139	17	traf3	traf3	NOUN
biomedich-293	139	18	-	-	PUNCT
biomedich-293	139	19	dependent	dependent	ADJ
biomedich-293	139	20	ubiquitination	ubiquitination	NOUN
biomedich-293	139	21	190	190	NUM
biomedich-293	139	22	biology	biology	NOUN
biomedich-293	139	23	,	,	PUNCT
biomedich-293	139	24	medicine	medicine	NOUN
biomedich-293	139	25	,	,	PUNCT
biomedich-293	139	26	&	&	CCONJ
biomedich-293	139	27	natural	natural	ADJ
biomedich-293	139	28	product	product	NOUN
biomedich-293	139	29	chemistry	chemistry	NOUN
biomedich-293	139	30	12	12	NUM
biomedich-293	139	31	(	(	PUNCT
biomedich-293	139	32	1	1	NUM
biomedich-293	139	33	)	)	PUNCT
biomedich-293	139	34	,	,	PUNCT
biomedich-293	139	35	2023	2023	NUM
biomedich-293	139	36	:	:	PUNCT
biomedich-293	139	37	187	187	NUM
biomedich-293	139	38	-	-	SYM
biomedich-293	139	39	190	190	NUM
biomedich-293	139	40	of	of	ADP
biomedich-293	139	41	asc	asc	PROPN
biomedich-293	139	42	.	.	PROPN
biomedich-293	139	43	faseb	faseb	PROPN
biomedich-293	139	44	j.	j.	PROPN
biomedich-293	139	45	2019;33:8865–8877	2019;33:8865–8877	PROPN
biomedich-293	139	46	.	.	PUNCT
biomedich-293	140	1	doi	doi	NOUN
biomedich-293	140	2	:	:	PUNCT
biomedich-293	140	3	10.1096	10.1096	NUM
biomedich-293	140	4	/	/	SYM
biomedich-293	140	5	fj.201802418r	fj.201802418r	PROPN
biomedich-293	140	6	.	.	PUNCT
biomedich-293	141	1	tanaka	tanaka	PROPN
biomedich-293	141	2	t.	t.	PROPN
biomedich-293	141	3	,	,	PUNCT
biomedich-293	141	4	narazaki	narazaki	PROPN
biomedich-293	141	5	m.	m.	PROPN
biomedich-293	141	6	,	,	PUNCT
biomedich-293	141	7	kishimoto	kishimoto	PROPN
biomedich-293	141	8	t.	t.	PROPN
biomedich-293	141	9	(	(	PUNCT
biomedich-293	141	10	2016	2016	NUM
biomedich-293	141	11	)	)	PUNCT
biomedich-293	141	12	immunotherapeutic	immunotherapeutic	ADJ
biomedich-293	141	13	implications	implication	NOUN
biomedich-293	141	14	of	of	ADP
biomedich-293	141	15	il-6	il-6	NOUN
biomedich-293	141	16	blockade	blockade	NOUN
biomedich-293	141	17	for	for	ADP
biomedich-293	141	18	cytokine	cytokine	ADJ
biomedich-293	141	19	storm	storm	NOUN
biomedich-293	141	20	.	.	PUNCT
biomedich-293	142	1	immunotherapy	immunotherapy	NOUN
biomedich-293	142	2	.	.	PUNCT
biomedich-293	143	1	2016;8:959	2016;8:959	NOUN
biomedich-293	143	2	970	970	NUM
biomedich-293	143	3	.	.	PUNCT
biomedich-293	143	4	doi	doi	NOUN
biomedich-293	143	5	:	:	PUNCT
biomedich-293	143	6	10.2217	10.2217	NUM
biomedich-293	143	7	/	/	SYM
biomedich-293	143	8	imt-2016	imt-2016	NOUN
biomedich-293	143	9	-	-	PUNCT
biomedich-293	143	10	0020	0020	NUM
biomedich-293	143	11	.	.	PUNCT
biomedich-293	144	1	turner	turner	PROPN
biomedich-293	144	2	m.d	m.d	PROPN
biomedich-293	144	3	.	.	PROPN
biomedich-293	144	4	,	,	PUNCT
biomedich-293	144	5	nedjai	nedjai	PROPN
biomedich-293	144	6	b.	b.	PROPN
biomedich-293	144	7	,	,	PUNCT
biomedich-293	144	8	hurst	hurst	PROPN
biomedich-293	144	9	t.	t.	PROPN
biomedich-293	144	10	,	,	PUNCT
biomedich-293	144	11	pennington	pennington	PROPN
biomedich-293	144	12	d.j	d.j	PROPN
biomedich-293	144	13	.	.	PROPN
biomedich-293	144	14	(	(	PUNCT
biomedich-293	144	15	2014	2014	NUM
biomedich-293	144	16	)	)	PUNCT
biomedich-293	144	17	cytokines	cytokine	NOUN
biomedich-293	144	18	and	and	CCONJ
biomedich-293	144	19	chemokines	chemokine	NOUN
biomedich-293	144	20	:	:	PUNCT
biomedich-293	144	21	at	at	ADP
biomedich-293	144	22	the	the	DET
biomedich-293	144	23	crossroads	crossroad	NOUN
biomedich-293	144	24	of	of	ADP
biomedich-293	144	25	cell	cell	NOUN
biomedich-293	144	26	signalling	signal	VERB
biomedich-293	144	27	and	and	CCONJ
biomedich-293	144	28	inflammatory	inflammatory	ADJ
biomedich-293	144	29	disease	disease	NOUN
biomedich-293	144	30	.	.	PUNCT
biomedich-293	145	1	biochim	biochim	NOUN
biomedich-293	145	2	.	.	PUNCT
biomedich-293	146	1	biophys	biophy	NOUN
biomedich-293	146	2	.	.	PUNCT
biomedich-293	147	1	acta	acta	PROPN
biomedich-293	147	2	.	.	PUNCT
biomedich-293	148	1	2014;1843:2563–2582	2014;1843:2563–2582	NUM
biomedich-293	148	2	.	.	PUNCT
biomedich-293	149	1	doi	doi	NOUN
biomedich-293	149	2	:	:	PUNCT
biomedich-293	149	3	10.1016	10.1016	NUM
biomedich-293	149	4	/	/	SYM
biomedich-293	149	5	j.bbamcr.2014.05.014	j.bbamcr.2014.05.014	PROPN
biomedich-293	149	6	.	.	PUNCT
biomedich-293	150	1	wan	wan	PROPN
biomedich-293	150	2	s.	s.	PROPN
biomedich-293	150	3	,	,	PUNCT
biomedich-293	150	4	yi	yi	PROPN
biomedich-293	150	5	q.	q.	PROPN
biomedich-293	150	6	,	,	PUNCT
biomedich-293	150	7	fan	fan	PROPN
biomedich-293	150	8	s.	s.	PROPN
biomedich-293	150	9	,	,	PUNCT
biomedich-293	150	10	lv	lv	PROPN
biomedich-293	150	11	j.	j.	PROPN
biomedich-293	150	12	,	,	PUNCT
biomedich-293	150	13	zhang	zhang	PROPN
biomedich-293	150	14	x.	x.	PROPN
biomedich-293	150	15	,	,	PUNCT
biomedich-293	150	16	guo	guo	PROPN
biomedich-293	150	17	l.	l.	PROPN
biomedich-293	150	18	,	,	PUNCT
biomedich-293	150	19	lang	lang	PROPN
biomedich-293	150	20	c.	c.	PROPN
biomedich-293	150	21	,	,	PUNCT
biomedich-293	150	22	xiao	xiao	PROPN
biomedich-293	150	23	q.	q.	PROPN
biomedich-293	150	24	,	,	PUNCT
biomedich-293	150	25	xiao	xiao	PROPN
biomedich-293	150	26	k.	k.	PROPN
biomedich-293	150	27	,	,	PUNCT
biomedich-293	150	28	yi	yi	PROPN
biomedich-293	150	29	z.	z.	PROPN
biomedich-293	150	30	,	,	PUNCT
biomedich-293	150	31	qiang	qiang	PROPN
biomedich-293	150	32	m.	m.	PROPN
biomedich-293	150	33	,	,	PUNCT
biomedich-293	150	34	xiang	xiang	PROPN
biomedich-293	150	35	j.	j.	PROPN
biomedich-293	150	36	,	,	PUNCT
biomedich-293	150	37	zhang	zhang	PROPN
biomedich-293	150	38	b.	b.	PROPN
biomedich-293	150	39	,	,	PUNCT
biomedich-293	150	40	chen	chen	PROPN
biomedich-293	150	41	y.	y.	PROPN
biomedich-293	150	42	(	(	PUNCT
biomedich-293	150	43	2020	2020	NUM
biomedich-293	150	44	)	)	PUNCT
biomedich-293	150	45	characteristics	characteristic	NOUN
biomedich-293	150	46	of	of	ADP
biomedich-293	150	47	lymphocyte	lymphocyte	ADJ
biomedich-293	150	48	subsets	subset	NOUN
biomedich-293	150	49	and	and	CCONJ
biomedich-293	150	50	cytokines	cytokine	NOUN
biomedich-293	150	51	in	in	ADP
biomedich-293	150	52	peripheral	peripheral	ADJ
biomedich-293	150	53	blood	blood	NOUN
biomedich-293	150	54	of	of	ADP
biomedich-293	150	55	123	123	NUM
biomedich-293	150	56	hospitalized	hospitalize	VERB
biomedich-293	150	57	patients	patient	NOUN
biomedich-293	150	58	with	with	ADP
biomedich-293	150	59	2019	2019	NUM
biomedich-293	150	60	novel	novel	ADJ
biomedich-293	150	61	coronavirus	coronavirus	NOUN
biomedich-293	150	62	pneumonia	pneumonia	NOUN
biomedich-293	150	63	(	(	PUNCT
biomedich-293	150	64	ncp	ncp	NOUN
biomedich-293	150	65	)	)	PUNCT
biomedich-293	150	66	hematology	hematology	NOUN
biomedich-293	150	67	.	.	PUNCT
biomedich-293	151	1	2020	2020	NUM
biomedich-293	151	2	doi	doi	NOUN
biomedich-293	151	3	:	:	PUNCT
biomedich-293	151	4	10.1101/2020.02.10.20021832	10.1101/2020.02.10.20021832	NUM
biomedich-293	151	5	.	.	PUNCT
biomedich-293	152	1	yang	yang	PROPN
biomedich-293	152	2	y.	y.	PROPN
biomedich-293	152	3	,	,	PUNCT
biomedich-293	152	4	shen	shen	PROPN
biomedich-293	152	5	c.	c.	PROPN
biomedich-293	152	6	,	,	PUNCT
biomedich-293	152	7	li	li	PROPN
biomedich-293	152	8	j.	j.	PROPN
biomedich-293	152	9	,	,	PUNCT
biomedich-293	152	10	yuan	yuan	PROPN
biomedich-293	152	11	j.	j.	PROPN
biomedich-293	152	12	,	,	PUNCT
biomedich-293	152	13	yang	yang	PROPN
biomedich-293	152	14	m.	m.	PROPN
biomedich-293	152	15	,	,	PUNCT
biomedich-293	152	16	wang	wang	PROPN
biomedich-293	152	17	f.	f.	PROPN
biomedich-293	152	18	,	,	PUNCT
biomedich-293	152	19	li	li	PROPN
biomedich-293	152	20	g.	g.	PROPN
biomedich-293	152	21	,	,	PUNCT
biomedich-293	152	22	li	li	PROPN
biomedich-293	152	23	y.	y.	PROPN
biomedich-293	152	24	,	,	PUNCT
biomedich-293	152	25	xing	xing	PROPN
biomedich-293	152	26	l.	l.	PROPN
biomedich-293	152	27	,	,	PUNCT
biomedich-293	152	28	peng	peng	PROPN
biomedich-293	152	29	l.	l.	PROPN
biomedich-293	152	30	,	,	PUNCT
biomedich-293	152	31	wei	wei	PROPN
biomedich-293	152	32	j.	j.	PROPN
biomedich-293	152	33	,	,	PUNCT
biomedich-293	152	34	cao	cao	PROPN
biomedich-293	152	35	m.	m.	PROPN
biomedich-293	152	36	,	,	PUNCT
biomedich-293	152	37	zheng	zheng	PROPN
biomedich-293	152	38	h.	h.	PROPN
biomedich-293	152	39	,	,	PUNCT
biomedich-293	152	40	wu	wu	PROPN
biomedich-293	152	41	w.	w.	PROPN
biomedich-293	152	42	,	,	PUNCT
biomedich-293	152	43	zou	zou	PROPN
biomedich-293	152	44	r.	r.	PROPN
biomedich-293	152	45	,	,	PUNCT
biomedich-293	152	46	li	li	PROPN
biomedich-293	152	47	d.	d.	PROPN
biomedich-293	152	48	,	,	PUNCT
biomedich-293	152	49	xu	xu	PROPN
biomedich-293	152	50	z.	z.	PROPN
biomedich-293	152	51	,	,	PUNCT
biomedich-293	152	52	wang	wang	PROPN
biomedich-293	152	53	h.	h.	PROPN
biomedich-293	152	54	,	,	PUNCT
biomedich-293	152	55	zhang	zhang	PROPN
biomedich-293	152	56	m.	m.	PROPN
biomedich-293	152	57	,	,	PUNCT
biomedich-293	152	58	zhang	zhang	PROPN
biomedich-293	152	59	z.	z.	PROPN
biomedich-293	152	60	,	,	PUNCT
biomedich-293	152	61	liu	liu	PROPN
biomedich-293	152	62	l.	l.	PROPN
biomedich-293	152	63	,	,	PUNCT
biomedich-293	152	64	liu	liu	PROPN
biomedich-293	152	65	y.	y.	PROPN
biomedich-293	152	66	(	(	PUNCT
biomedich-293	152	67	2020	2020	NUM
biomedich-293	152	68	)	)	PUNCT
biomedich-293	152	69	exuberant	exuberant	ADJ
biomedich-293	152	70	elevation	elevation	NOUN
biomedich-293	152	71	of	of	ADP
biomedich-293	152	72	ip-10	ip-10	PRON
biomedich-293	152	73	,	,	PUNCT
biomedich-293	152	74	mcp-3	mcp-3	NUM
biomedich-293	152	75	and	and	CCONJ
biomedich-293	152	76	il-1ra	il-1ra	VERB
biomedich-293	152	77	during	during	ADP
biomedich-293	152	78	sars	sar	NOUN
biomedich-293	152	79	-	-	PUNCT
biomedich-293	152	80	cov-2	cov-2	PART
biomedich-293	152	81	infection	infection	NOUN
biomedich-293	152	82	is	be	AUX
biomedich-293	152	83	associated	associate	VERB
biomedich-293	152	84	with	with	ADP
biomedich-293	152	85	disease	disease	NOUN
biomedich-293	152	86	severity	severity	NOUN
biomedich-293	152	87	and	and	CCONJ
biomedich-293	152	88	fatal	fatal	ADJ
biomedich-293	152	89	outcome	outcome	NOUN
biomedich-293	152	90	.	.	PUNCT
biomedich-293	153	1	infectious	infectious	ADJ
biomedich-293	153	2	diseases	disease	NOUN
biomedich-293	153	3	(	(	PUNCT
biomedich-293	153	4	except	except	SCONJ
biomedich-293	153	5	hiv	hiv	PROPN
biomedich-293	153	6	/	/	SYM
biomedich-293	153	7	aids	aids	PROPN
biomedich-293	153	8	)	)	PUNCT
biomedich-293	153	9	2020	2020	NUM
biomedich-293	153	10	doi	doi	NOUN
biomedich-293	153	11	:	:	PUNCT
biomedich-293	153	12	10.1101/2020.03.02.20029975	10.1101/2020.03.02.20029975	NUM
biomedich-293	153	13	.	.	PUNCT
biomedich-293	154	1	zhang	zhang	PROPN
biomedich-293	154	2	w.	w.	PROPN
biomedich-293	154	3	,	,	PUNCT
biomedich-293	154	4	zhao	zhao	PROPN
biomedich-293	154	5	y.	y.	PROPN
biomedich-293	154	6	,	,	PUNCT
biomedich-293	154	7	zhang	zhang	PROPN
biomedich-293	154	8	f.	f.	PROPN
biomedich-293	154	9	,	,	PUNCT
biomedich-293	154	10	wang	wang	PROPN
biomedich-293	154	11	q.	q.	PROPN
biomedich-293	154	12	,	,	PUNCT
biomedich-293	154	13	li	li	PROPN
biomedich-293	154	14	t.	t.	PROPN
biomedich-293	154	15	,	,	PUNCT
biomedich-293	154	16	liu	liu	PROPN
biomedich-293	154	17	z.	z.	PROPN
biomedich-293	154	18	,	,	PUNCT
biomedich-293	154	19	wang	wang	PROPN
biomedich-293	154	20	j.	j.	PROPN
biomedich-293	154	21	,	,	PUNCT
biomedich-293	154	22	qin	qin	PROPN
biomedich-293	154	23	y.	y.	PROPN
biomedich-293	154	24	,	,	PUNCT
biomedich-293	154	25	zhang	zhang	PROPN
biomedich-293	154	26	x.	x.	PROPN
biomedich-293	154	27	,	,	PUNCT
biomedich-293	154	28	yan	yan	PROPN
biomedich-293	154	29	x.	x.	PROPN
biomedich-293	154	30	,	,	PUNCT
biomedich-293	154	31	zeng	zeng	PROPN
biomedich-293	154	32	x.	x.	PROPN
biomedich-293	154	33	,	,	PUNCT
biomedich-293	154	34	zhang	zhang	PROPN
biomedich-293	154	35	s.	s.	PROPN
biomedich-293	154	36	(	(	PUNCT
biomedich-293	154	37	2020	2020	NUM
biomedich-293	154	38	)	)	PUNCT
biomedich-293	154	39	the	the	DET
biomedich-293	154	40	use	use	NOUN
biomedich-293	154	41	of	of	ADP
biomedich-293	154	42	anti	anti	ADJ
biomedich-293	154	43	-	-	ADJ
biomedich-293	154	44	inflammatory	inflammatory	ADJ
biomedich-293	154	45	drugs	drug	NOUN
biomedich-293	154	46	in	in	ADP
biomedich-293	154	47	the	the	DET
biomedich-293	154	48	treatment	treatment	NOUN
biomedich-293	154	49	of	of	ADP
biomedich-293	154	50	people	people	NOUN
biomedich-293	154	51	with	with	ADP
biomedich-293	154	52	severe	severe	ADJ
biomedich-293	154	53	coronavirus	coronavirus	NOUN
biomedich-293	154	54	disease	disease	NOUN
biomedich-293	154	55	2019	2019	NUM
biomedich-293	154	56	(	(	PUNCT
biomedich-293	154	57	covid-19	covid-19	PROPN
biomedich-293	154	58	):	):	PUNCT
biomedich-293	154	59	the	the	DET
biomedich-293	154	60	perspectives	perspective	NOUN
biomedich-293	154	61	of	of	ADP
biomedich-293	154	62	clinical	clinical	ADJ
biomedich-293	154	63	immunologists	immunologist	NOUN
biomedich-293	154	64	from	from	ADP
biomedich-293	154	65	china	china	PROPN
biomedich-293	154	66	.	.	PUNCT
biomedich-293	155	1	clin	clin	PROPN
biomedich-293	155	2	.	.	PUNCT
biomedich-293	156	1	immunol	immunol	PROPN
biomedich-293	156	2	.	.	PUNCT
biomedich-293	157	1	2020;214	2020;214	NUM
biomedich-293	157	2	doi	doi	NOUN
biomedich-293	157	3	:	:	PUNCT
biomedich-293	157	4	10.1016	10.1016	NUM
biomedich-293	157	5	/	/	SYM
biomedich-293	157	6	j.clim.2020.108393	j.clim.2020.108393	PROPN
biomedich-293	157	7	.	.	PUNCT