id	sid	tid	token	lemma	pos
biomedich-396	1	1	biology	biology	NOUN
biomedich-396	1	2	,	,	PUNCT
biomedich-396	1	3	medicine	medicine	NOUN
biomedich-396	1	4	,	,	PUNCT
biomedich-396	1	5	&	&	CCONJ
biomedich-396	1	6	natural	natural	ADJ
biomedich-396	1	7	product	product	NOUN
biomedich-396	1	8	chemistry	chemistry	NOUN
biomedich-396	1	9	issn	issn	VERB
biomedich-396	1	10	2089	2089	NUM
biomedich-396	1	11	-	-	SYM
biomedich-396	1	12	6514	6514	NUM
biomedich-396	1	13	(	(	PUNCT
biomedich-396	1	14	paper	paper	NOUN
biomedich-396	1	15	)	)	PUNCT
biomedich-396	1	16	volume	volume	NOUN
biomedich-396	1	17	12	12	NUM
biomedich-396	1	18	,	,	PUNCT
biomedich-396	1	19	number	number	NOUN
biomedich-396	1	20	2	2	NUM
biomedich-396	1	21	,	,	PUNCT
biomedich-396	1	22	october	october	PROPN
biomedich-396	1	23	2023	2023	NUM
biomedich-396	2	1	|	|	NOUN
biomedich-396	2	2	pages	page	NOUN
biomedich-396	2	3	:	:	PUNCT
biomedich-396	2	4	441	441	NUM
biomedich-396	2	5	-	-	SYM
biomedich-396	2	6	450	450	NUM
biomedich-396	2	7	|	|	ADV
biomedich-396	2	8	doi	doi	NOUN
biomedich-396	2	9	:	:	PUNCT
biomedich-396	2	10	10.14421	10.14421	NUM
biomedich-396	2	11	/	/	SYM
biomedich-396	2	12	biomedich.2023.122.441	biomedich.2023.122.441	NOUN
biomedich-396	2	13	-	-	SYM
biomedich-396	2	14	450	450	NUM
biomedich-396	2	15	issn	issn	PROPN
biomedich-396	2	16	2540	2540	NUM
biomedich-396	2	17	-	-	SYM
biomedich-396	2	18	9328	9328	NUM
biomedich-396	2	19	(	(	PUNCT
biomedich-396	2	20	online	online	ADJ
biomedich-396	2	21	)	)	PUNCT
biomedich-396	2	22	alkaloids	alkaloid	NOUN
biomedich-396	2	23	lead	lead	VERB
biomedich-396	2	24	to	to	ADP
biomedich-396	2	25	potential	potential	ADJ
biomedich-396	2	26	inhibition	inhibition	NOUN
biomedich-396	2	27	of	of	ADP
biomedich-396	2	28	the	the	DET
biomedich-396	2	29	acyl	acyl	ADJ
biomedich-396	2	30	carrier	carrier	NOUN
biomedich-396	2	31	protein	protein	NOUN
biomedich-396	2	32	reductase	reductase	NOUN
biomedich-396	2	33	to	to	PART
biomedich-396	2	34	attenuate	attenuate	VERB
biomedich-396	2	35	tuberculosis	tuberculosis	NOUN
biomedich-396	2	36	;	;	PUNCT
biomedich-396	2	37	an	an	DET
biomedich-396	2	38	in	in	ADP
biomedich-396	2	39	-	-	PUNCT
biomedich-396	2	40	silico	silico	NOUN
biomedich-396	2	41	analysis	analysis	NOUN
biomedich-396	2	42	pernia	pernia	NOUN
biomedich-396	2	43	kamran	kamran	PROPN
biomedich-396	2	44	,	,	PUNCT
biomedich-396	2	45	ahsan	ahsan	PROPN
biomedich-396	2	46	ibrahim	ibrahim	PROPN
biomedich-396	2	47	*	*	PROPN
biomedich-396	2	48	shifa	shifa	PROPN
biomedich-396	2	49	college	college	PROPN
biomedich-396	2	50	of	of	ADP
biomedich-396	2	51	pharmaceutical	pharmaceutical	NOUN
biomedich-396	2	52	sciences	sciences	PROPN
biomedich-396	2	53	,	,	PUNCT
biomedich-396	2	54	shifa	shifa	PROPN
biomedich-396	2	55	tameer	tameer	NOUN
biomedich-396	2	56	-	-	PUNCT
biomedich-396	2	57	e	e	NOUN
biomedich-396	2	58	-	-	PROPN
biomedich-396	2	59	millat	millat	ADJ
biomedich-396	2	60	university	university	NOUN
biomedich-396	2	61	,	,	PUNCT
biomedich-396	2	62	islamabad-44000	islamabad-44000	NOUN
biomedich-396	2	63	,	,	PUNCT
biomedich-396	2	64	tel	tel	PROPN
biomedich-396	2	65	.	.	PROPN
biomedich-396	2	66	+9251	+9251	PROPN
biomedich-396	2	67	-	-	SYM
biomedich-396	2	68	8438061	8438061	NUM
biomedich-396	2	69	,	,	PUNCT
biomedich-396	2	70	pakistan	pakistan	PROPN
biomedich-396	2	71	.	.	PUNCT
biomedich-396	3	1	corresponding	correspond	VERB
biomedich-396	3	2	author	author	NOUN
biomedich-396	3	3	*	*	X
biomedich-396	3	4	ahsan.scps@stmu.edu.pk	ahsan.scps@stmu.edu.pk	VERB
biomedich-396	3	5	abstract	abstract	ADJ
biomedich-396	3	6	tuberculosis	tuberculosis	NOUN
biomedich-396	3	7	(	(	PUNCT
biomedich-396	3	8	tb	tb	NOUN
biomedich-396	3	9	)	)	PUNCT
biomedich-396	3	10	is	be	AUX
biomedich-396	3	11	a	a	DET
biomedich-396	3	12	contagious	contagious	ADJ
biomedich-396	3	13	infection	infection	NOUN
biomedich-396	3	14	that	that	PRON
biomedich-396	3	15	mostly	mostly	ADV
biomedich-396	3	16	affects	affect	VERB
biomedich-396	3	17	the	the	DET
biomedich-396	3	18	lungs	lung	NOUN
biomedich-396	3	19	.	.	PUNCT
biomedich-396	4	1	mycobacterium	mycobacterium	NOUN
biomedich-396	4	2	tuberculosis	tuberculosis	NOUN
biomedich-396	4	3	causes	cause	VERB
biomedich-396	4	4	tuberculosis	tuberculosis	NOUN
biomedich-396	4	5	infection	infection	NOUN
biomedich-396	4	6	,	,	PUNCT
biomedich-396	4	7	leading	lead	VERB
biomedich-396	4	8	to	to	ADP
biomedich-396	4	9	granulomatous	granulomatous	ADJ
biomedich-396	4	10	lesions	lesion	NOUN
biomedich-396	4	11	in	in	ADP
biomedich-396	4	12	affected	affected	ADJ
biomedich-396	4	13	lung	lung	NOUN
biomedich-396	4	14	tissue	tissue	NOUN
biomedich-396	4	15	.	.	PUNCT
biomedich-396	5	1	it	it	PRON
biomedich-396	5	2	is	be	AUX
biomedich-396	5	3	one	one	NUM
biomedich-396	5	4	of	of	ADP
biomedich-396	5	5	the	the	DET
biomedich-396	5	6	most	most	ADV
biomedich-396	5	7	prevalent	prevalent	ADJ
biomedich-396	5	8	and	and	CCONJ
biomedich-396	5	9	deadly	deadly	ADJ
biomedich-396	5	10	infectious	infectious	ADJ
biomedich-396	5	11	diseases	disease	NOUN
biomedich-396	5	12	among	among	ADP
biomedich-396	5	13	the	the	DET
biomedich-396	5	14	under	under	ADP
biomedich-396	5	15	developed	develop	VERB
biomedich-396	5	16	countries	country	NOUN
biomedich-396	5	17	.	.	PUNCT
biomedich-396	6	1	this	this	DET
biomedich-396	6	2	study	study	NOUN
biomedich-396	6	3	aims	aim	VERB
biomedich-396	6	4	to	to	PART
biomedich-396	6	5	investigate	investigate	VERB
biomedich-396	6	6	the	the	DET
biomedich-396	6	7	possible	possible	ADJ
biomedich-396	6	8	inhibition	inhibition	NOUN
biomedich-396	6	9	of	of	ADP
biomedich-396	6	10	the	the	DET
biomedich-396	6	11	acyl	acyl	ADJ
biomedich-396	6	12	carrier	carrier	NOUN
biomedich-396	6	13	protein	protein	NOUN
biomedich-396	6	14	reductase	reductase	NOUN
biomedich-396	6	15	for	for	ADP
biomedich-396	6	16	preventing	prevent	VERB
biomedich-396	6	17	tuberculosis	tuberculosis	NOUN
biomedich-396	6	18	by	by	ADP
biomedich-396	6	19	well	well	ADV
biomedich-396	6	20	-	-	PUNCT
biomedich-396	6	21	known	know	VERB
biomedich-396	6	22	alkaloids	alkaloid	NOUN
biomedich-396	6	23	,	,	PUNCT
biomedich-396	6	24	thereby	thereby	ADV
biomedich-396	6	25	reducing	reduce	VERB
biomedich-396	6	26	mycobacterium	mycobacterium	NOUN
biomedich-396	6	27	tuberculosis	tuberculosis	NOUN
biomedich-396	6	28	growth	growth	NOUN
biomedich-396	6	29	in	in	ADP
biomedich-396	6	30	the	the	DET
biomedich-396	6	31	lungs	lung	NOUN
biomedich-396	6	32	and	and	CCONJ
biomedich-396	6	33	thereby	thereby	ADV
biomedich-396	6	34	reducing	reduce	VERB
biomedich-396	6	35	the	the	DET
biomedich-396	6	36	incidence	incidence	NOUN
biomedich-396	6	37	of	of	ADP
biomedich-396	6	38	latent	latent	NOUN
biomedich-396	6	39	and	and	CCONJ
biomedich-396	6	40	active	active	ADJ
biomedich-396	6	41	tb	tb	NOUN
biomedich-396	6	42	.	.	PUNCT
biomedich-396	7	1	about	about	ADV
biomedich-396	7	2	five	five	NUM
biomedich-396	7	3	natural	natural	ADJ
biomedich-396	7	4	alkaloids	alkaloid	NOUN
biomedich-396	7	5	were	be	AUX
biomedich-396	7	6	subjected	subject	VERB
biomedich-396	7	7	to	to	ADP
biomedich-396	7	8	the	the	DET
biomedich-396	7	9	molecular	molecular	ADJ
biomedich-396	7	10	docking	docking	NOUN
biomedich-396	7	11	analysis	analysis	NOUN
biomedich-396	7	12	,	,	PUNCT
biomedich-396	7	13	which	which	PRON
biomedich-396	7	14	produced	produce	VERB
biomedich-396	7	15	favorable	favorable	ADJ
biomedich-396	7	16	findings	finding	NOUN
biomedich-396	7	17	in	in	ADP
biomedich-396	7	18	terms	term	NOUN
biomedich-396	7	19	of	of	ADP
biomedich-396	7	20	best	good	ADJ
biomedich-396	7	21	pose	pose	NOUN
biomedich-396	7	22	and	and	CCONJ
biomedich-396	7	23	binding	bind	VERB
biomedich-396	7	24	energies	energy	NOUN
biomedich-396	7	25	of	of	ADP
biomedich-396	7	26	these	these	DET
biomedich-396	7	27	compounds	compound	NOUN
biomedich-396	7	28	towards	towards	ADP
biomedich-396	7	29	the	the	DET
biomedich-396	7	30	active	active	ADJ
biomedich-396	7	31	residues	residue	NOUN
biomedich-396	7	32	of	of	ADP
biomedich-396	7	33	mycobacterial	mycobacterial	ADJ
biomedich-396	7	34	acp	acp	PROPN
biomedich-396	7	35	reductase	reductase	NOUN
biomedich-396	7	36	,	,	PUNCT
biomedich-396	7	37	with	with	ADP
biomedich-396	7	38	values	value	NOUN
biomedich-396	7	39	ranging	range	VERB
biomedich-396	7	40	from	from	ADP
biomedich-396	7	41	-10	-10	X
biomedich-396	7	42	kcal	kcal	NOUN
biomedich-396	7	43	/	/	SYM
biomedich-396	7	44	mol	mol	NOUN
biomedich-396	7	45	to	to	ADP
biomedich-396	7	46	-9.1	-9.1	PROPN
biomedich-396	7	47	kcal	kcal	PROPN
biomedich-396	7	48	/	/	SYM
biomedich-396	7	49	mol	mol	PROPN
biomedich-396	7	50	.	.	PUNCT
biomedich-396	8	1	the	the	DET
biomedich-396	8	2	molecular	molecular	ADJ
biomedich-396	8	3	dynamics	dynamic	NOUN
biomedich-396	8	4	simulation	simulation	NOUN
biomedich-396	8	5	produced	produce	VERB
biomedich-396	8	6	similar	similar	ADJ
biomedich-396	8	7	encouraging	encouraging	ADJ
biomedich-396	8	8	results	result	NOUN
biomedich-396	8	9	.	.	PUNCT
biomedich-396	9	1	all	all	PRON
biomedich-396	9	2	of	of	ADP
biomedich-396	9	3	the	the	DET
biomedich-396	9	4	prospective	prospective	ADJ
biomedich-396	9	5	alkaloid	alkaloid	PROPN
biomedich-396	9	6	compounds	compound	NOUN
biomedich-396	9	7	were	be	AUX
biomedich-396	9	8	subjected	subject	VERB
biomedich-396	9	9	to	to	ADP
biomedich-396	9	10	an	an	DET
biomedich-396	9	11	in	in	ADP
biomedich-396	9	12	-	-	PUNCT
biomedich-396	9	13	silico	silico	NOUN
biomedich-396	9	14	toxicity	toxicity	NOUN
biomedich-396	9	15	investigation	investigation	NOUN
biomedich-396	9	16	,	,	PUNCT
biomedich-396	9	17	which	which	PRON
biomedich-396	9	18	determined	determine	VERB
biomedich-396	9	19	that	that	SCONJ
biomedich-396	9	20	every	every	DET
biomedich-396	9	21	compound	compound	NOUN
biomedich-396	9	22	was	be	AUX
biomedich-396	9	23	safe	safe	ADJ
biomedich-396	9	24	and	and	CCONJ
biomedich-396	9	25	non	non	ADJ
biomedich-396	9	26	-	-	ADJ
biomedich-396	9	27	toxic	toxic	ADJ
biomedich-396	9	28	.	.	PUNCT
biomedich-396	10	1	further	further	ADJ
biomedich-396	10	2	studies	study	NOUN
biomedich-396	10	3	may	may	AUX
biomedich-396	10	4	be	be	AUX
biomedich-396	10	5	necessary	necessary	ADJ
biomedich-396	10	6	for	for	ADP
biomedich-396	10	7	effective	effective	ADJ
biomedich-396	10	8	formulation	formulation	NOUN
biomedich-396	10	9	development	development	NOUN
biomedich-396	10	10	employing	employ	VERB
biomedich-396	10	11	these	these	DET
biomedich-396	10	12	compounds	compound	NOUN
biomedich-396	10	13	as	as	ADP
biomedich-396	10	14	part	part	NOUN
biomedich-396	10	15	of	of	ADP
biomedich-396	10	16	the	the	DET
biomedich-396	10	17	process	process	NOUN
biomedich-396	10	18	of	of	ADP
biomedich-396	10	19	drug	drug	NOUN
biomedich-396	10	20	discovery	discovery	NOUN
biomedich-396	10	21	and	and	CCONJ
biomedich-396	10	22	development	development	NOUN
biomedich-396	10	23	.	.	PUNCT
biomedich-396	11	1	the	the	DET
biomedich-396	11	2	findings	finding	NOUN
biomedich-396	11	3	from	from	ADP
biomedich-396	11	4	this	this	DET
biomedich-396	11	5	study	study	NOUN
biomedich-396	11	6	may	may	AUX
biomedich-396	11	7	be	be	AUX
biomedich-396	11	8	helpful	helpful	ADJ
biomedich-396	11	9	in	in	ADP
biomedich-396	11	10	the	the	DET
biomedich-396	11	11	development	development	NOUN
biomedich-396	11	12	of	of	ADP
biomedich-396	11	13	the	the	DET
biomedich-396	11	14	novel	novel	ADJ
biomedich-396	11	15	nanoformulations	nanoformulation	NOUN
biomedich-396	11	16	using	use	VERB
biomedich-396	11	17	natural	natural	ADJ
biomedich-396	11	18	products	product	NOUN
biomedich-396	11	19	for	for	ADP
biomedich-396	11	20	pharmacotherapy	pharmacotherapy	NOUN
biomedich-396	11	21	of	of	ADP
biomedich-396	11	22	tuberculosis	tuberculosis	NOUN
biomedich-396	11	23	infection	infection	NOUN
biomedich-396	11	24	.	.	PUNCT
biomedich-396	12	1	keywords	keyword	NOUN
biomedich-396	12	2	:	:	PUNCT
biomedich-396	12	3	tuberculosis	tuberculosis	NOUN
biomedich-396	12	4	;	;	PUNCT
biomedich-396	12	5	alkaloids	alkaloid	NOUN
biomedich-396	12	6	;	;	PUNCT
biomedich-396	12	7	acp	acp	PROPN
biomedich-396	12	8	reductase	reductase	NOUN
biomedich-396	12	9	;	;	PUNCT
biomedich-396	12	10	molecular	molecular	ADJ
biomedich-396	12	11	docking	docking	NOUN
biomedich-396	12	12	analysis	analysis	NOUN
biomedich-396	12	13	;	;	PUNCT
biomedich-396	12	14	mycobacterium	mycobacterium	NOUN
biomedich-396	12	15	tuberculosis	tuberculosis	NOUN
biomedich-396	12	16	.	.	PUNCT
biomedich-396	13	1	abbreviations	abbreviation	NOUN
biomedich-396	13	2	:	:	PUNCT
biomedich-396	13	3	mtb	mtb	NOUN
biomedich-396	13	4	:	:	PUNCT
biomedich-396	13	5	mycobacterium	mycobacterium	NOUN
biomedich-396	13	6	tuberculosis	tuberculosis	NOUN
biomedich-396	13	7	,	,	PUNCT
biomedich-396	13	8	covid-19	covid-19	PROPN
biomedich-396	13	9	:	:	PUNCT
biomedich-396	13	10	corona	corona	NOUN
biomedich-396	13	11	virus	virus	NOUN
biomedich-396	13	12	disease	disease	NOUN
biomedich-396	13	13	19	19	NUM
biomedich-396	13	14	,	,	PUNCT
biomedich-396	13	15	hiv	hiv	PROPN
biomedich-396	13	16	:	:	PUNCT
biomedich-396	13	17	human	human	ADJ
biomedich-396	13	18	immunodeficiency	immunodeficiency	NOUN
biomedich-396	13	19	viruses	virus	NOUN
biomedich-396	13	20	,	,	PUNCT
biomedich-396	13	21	aids	aids	PROPN
biomedich-396	13	22	:	:	PUNCT
biomedich-396	13	23	acquired	acquire	VERB
biomedich-396	13	24	immunodeficiency	immunodeficiency	NOUN
biomedich-396	13	25	syndrome	syndrome	NOUN
biomedich-396	13	26	(	(	PUNCT
biomedich-396	13	27	aids	aids	PROPN
biomedich-396	13	28	)	)	PUNCT
biomedich-396	13	29	,	,	PUNCT
biomedich-396	13	30	acp	acp	PROPN
biomedich-396	13	31	:	:	PUNCT
biomedich-396	13	32	acyl	acyl	NOUN
biomedich-396	13	33	carrier	carrier	NOUN
biomedich-396	13	34	protein	protein	NOUN
biomedich-396	13	35	,	,	PUNCT
biomedich-396	13	36	pdb	pdb	NOUN
biomedich-396	13	37	:	:	PUNCT
biomedich-396	13	38	protein	protein	NOUN
biomedich-396	13	39	data	data	PROPN
biomedich-396	13	40	bank	bank	PROPN
biomedich-396	13	41	.	.	PUNCT
biomedich-396	14	1	introduction	introduction	NOUN
biomedich-396	14	2	tuberculosis	tuberculosis	NOUN
biomedich-396	14	3	(	(	PUNCT
biomedich-396	14	4	tb	tb	NOUN
biomedich-396	14	5	)	)	PUNCT
biomedich-396	14	6	is	be	AUX
biomedich-396	14	7	an	an	DET
biomedich-396	14	8	infectious	infectious	ADJ
biomedich-396	14	9	disease	disease	NOUN
biomedich-396	14	10	caused	cause	VERB
biomedich-396	14	11	by	by	ADP
biomedich-396	14	12	the	the	DET
biomedich-396	14	13	bacteria	bacteria	NOUN
biomedich-396	14	14	mycobacterium	mycobacterium	NOUN
biomedich-396	14	15	tuberculosis	tuberculosis	NOUN
biomedich-396	14	16	.	.	PUNCT
biomedich-396	15	1	globally	globally	ADV
biomedich-396	15	2	,	,	PUNCT
biomedich-396	15	3	tuberculosis	tuberculosis	NOUN
biomedich-396	15	4	is	be	AUX
biomedich-396	15	5	the	the	DET
biomedich-396	15	6	13th	13th	ADJ
biomedich-396	15	7	leading	leading	ADJ
biomedich-396	15	8	cause	cause	NOUN
biomedich-396	15	9	of	of	ADP
biomedich-396	15	10	death	death	NOUN
biomedich-396	15	11	after	after	ADP
biomedich-396	15	12	covid-19	covid-19	PROPN
biomedich-396	15	13	(	(	PUNCT
biomedich-396	15	14	ahead	ahead	ADV
biomedich-396	15	15	of	of	ADP
biomedich-396	15	16	hiv	hiv	PROPN
biomedich-396	15	17	and	and	CCONJ
biomedich-396	15	18	aids	aids	PROPN
biomedich-396	15	19	)	)	PUNCT
biomedich-396	15	20	and	and	CCONJ
biomedich-396	15	21	the	the	DET
biomedich-396	15	22	second	second	ADJ
biomedich-396	15	23	infectious	infectious	ADJ
biomedich-396	15	24	disease	disease	NOUN
biomedich-396	15	25	killer	killer	NOUN
biomedich-396	15	26	.	.	PUNCT
biomedich-396	16	1	in	in	ADP
biomedich-396	16	2	2021	2021	NUM
biomedich-396	16	3	,	,	PUNCT
biomedich-396	16	4	approximately	approximately	ADV
biomedich-396	16	5	more	more	ADJ
biomedich-396	16	6	than	than	ADP
biomedich-396	16	7	10	10	NUM
biomedich-396	16	8	million	million	NUM
biomedich-396	16	9	people	people	NOUN
biomedich-396	16	10	worldwide	worldwide	ADV
biomedich-396	16	11	were	be	AUX
biomedich-396	16	12	infected	infect	VERB
biomedich-396	16	13	with	with	ADP
biomedich-396	16	14	tuberculosis	tuberculosis	NOUN
biomedich-396	16	15	.	.	PUNCT
biomedich-396	17	1	this	this	DET
biomedich-396	17	2	infection	infection	NOUN
biomedich-396	17	3	affects	affect	VERB
biomedich-396	17	4	the	the	DET
biomedich-396	17	5	people	people	NOUN
biomedich-396	17	6	of	of	ADP
biomedich-396	17	7	all	all	DET
biomedich-396	17	8	age	age	NOUN
biomedich-396	17	9	groups	group	NOUN
biomedich-396	17	10	in	in	ADP
biomedich-396	17	11	many	many	ADJ
biomedich-396	17	12	countries	country	NOUN
biomedich-396	17	13	(	(	PUNCT
biomedich-396	17	14	who	who	PRON
biomedich-396	17	15	,	,	PUNCT
biomedich-396	17	16	2023	2023	NUM
biomedich-396	17	17	)	)	PUNCT
biomedich-396	17	18	.	.	PUNCT
biomedich-396	18	1	mycobacterium	mycobacterium	NOUN
biomedich-396	18	2	tuberculosis	tuberculosis	NOUN
biomedich-396	18	3	(	(	PUNCT
biomedich-396	18	4	mtb	mtb	NOUN
biomedich-396	18	5	)	)	PUNCT
biomedich-396	18	6	has	have	VERB
biomedich-396	18	7	a	a	DET
biomedich-396	18	8	unique	unique	ADJ
biomedich-396	18	9	cell	cell	NOUN
biomedich-396	18	10	envelope	envelope	NOUN
biomedich-396	18	11	that	that	PRON
biomedich-396	18	12	is	be	AUX
biomedich-396	18	13	linked	link	VERB
biomedich-396	18	14	to	to	ADP
biomedich-396	18	15	its	its	PRON
biomedich-396	18	16	pathogenicity	pathogenicity	NOUN
biomedich-396	18	17	.	.	PUNCT
biomedich-396	19	1	the	the	DET
biomedich-396	19	2	presence	presence	NOUN
biomedich-396	19	3	of	of	ADP
biomedich-396	19	4	trehalose	trehalose	DET
biomedich-396	19	5	dimycolate	dimycolate	ADJ
biomedich-396	19	6	(	(	PUNCT
biomedich-396	19	7	tdm	tdm	NOUN
biomedich-396	19	8	)	)	PUNCT
biomedich-396	19	9	,	,	PUNCT
biomedich-396	19	10	a	a	DET
biomedich-396	19	11	free	free	ADJ
biomedich-396	19	12	glycolipid	glycolipid	NOUN
biomedich-396	19	13	that	that	PRON
biomedich-396	19	14	accumulates	accumulate	VERB
biomedich-396	19	15	in	in	ADP
biomedich-396	19	16	a	a	DET
biomedich-396	19	17	cord	cord	NOUN
biomedich-396	19	18	-	-	PUNCT
biomedich-396	19	19	like	like	ADJ
biomedich-396	19	20	pattern	pattern	NOUN
biomedich-396	19	21	on	on	ADP
biomedich-396	19	22	the	the	DET
biomedich-396	19	23	surface	surface	NOUN
biomedich-396	19	24	of	of	ADP
biomedich-396	19	25	the	the	DET
biomedich-396	19	26	cells	cell	NOUN
biomedich-396	19	27	and	and	CCONJ
biomedich-396	19	28	protects	protect	VERB
biomedich-396	19	29	the	the	DET
biomedich-396	19	30	tubercle	tubercle	NOUN
biomedich-396	19	31	bacillus	bacillus	NOUN
biomedich-396	19	32	from	from	ADP
biomedich-396	19	33	harmful	harmful	ADJ
biomedich-396	19	34	agents	agent	NOUN
biomedich-396	19	35	and	and	CCONJ
biomedich-396	19	36	the	the	DET
biomedich-396	19	37	host	host	NOUN
biomedich-396	19	38	's	's	PART
biomedich-396	19	39	immune	immune	ADJ
biomedich-396	19	40	system	system	NOUN
biomedich-396	19	41	,	,	PUNCT
biomedich-396	19	42	is	be	AUX
biomedich-396	19	43	another	another	DET
biomedich-396	19	44	feature	feature	NOUN
biomedich-396	19	45	of	of	ADP
biomedich-396	19	46	the	the	DET
biomedich-396	19	47	cell	cell	NOUN
biomedich-396	19	48	envelope	envelope	NOUN
biomedich-396	19	49	that	that	PRON
biomedich-396	19	50	is	be	AUX
biomedich-396	19	51	very	very	ADV
biomedich-396	19	52	noticeable	noticeable	ADJ
biomedich-396	19	53	.	.	PUNCT
biomedich-396	20	1	tdm	tdm	PROPN
biomedich-396	20	2	is	be	AUX
biomedich-396	20	3	covalently	covalently	ADV
biomedich-396	20	4	linked	link	VERB
biomedich-396	20	5	to	to	ADP
biomedich-396	20	6	the	the	DET
biomedich-396	20	7	cell	cell	NOUN
biomedich-396	20	8	wall	wall	NOUN
biomedich-396	20	9	peptidoglycan	peptidoglycan	PROPN
biomedich-396	20	10	via	via	ADP
biomedich-396	20	11	an	an	DET
biomedich-396	20	12	inner	inner	ADJ
biomedich-396	20	13	leaflet	leaflet	NOUN
biomedich-396	20	14	of	of	ADP
biomedich-396	20	15	the	the	DET
biomedich-396	20	16	outer	outer	ADJ
biomedich-396	20	17	membrane	membrane	NOUN
biomedich-396	20	18	by	by	ADP
biomedich-396	20	19	a	a	DET
biomedich-396	20	20	phosphodiester	phosphodiester	ADJ
biomedich-396	20	21	bond	bond	NOUN
biomedich-396	20	22	.	.	PUNCT
biomedich-396	21	1	the	the	DET
biomedich-396	21	2	primary	primary	ADJ
biomedich-396	21	3	components	component	NOUN
biomedich-396	21	4	of	of	ADP
biomedich-396	21	5	this	this	DET
biomedich-396	21	6	protective	protective	ADJ
biomedich-396	21	7	layer	layer	NOUN
biomedich-396	21	8	are	be	AUX
biomedich-396	21	9	mycolic	mycolic	ADJ
biomedich-396	21	10	acids	acid	NOUN
biomedich-396	21	11	.	.	PUNCT
biomedich-396	22	1	more	more	ADV
biomedich-396	22	2	precisely	precisely	ADV
biomedich-396	22	3	,	,	PUNCT
biomedich-396	22	4	the	the	DET
biomedich-396	22	5	cyclopropane	cyclopropane	NOUN
biomedich-396	22	6	rings	ring	NOUN
biomedich-396	22	7	in	in	ADP
biomedich-396	22	8	mycolic	mycolic	ADJ
biomedich-396	22	9	acid	acid	NOUN
biomedich-396	22	10	layer	layer	NOUN
biomedich-396	22	11	help	help	NOUN
biomedich-396	22	12	maintain	maintain	VERB
biomedich-396	22	13	the	the	DET
biomedich-396	22	14	complex	complex	NOUN
biomedich-396	22	15	's	's	PART
biomedich-396	22	16	structural	structural	ADJ
biomedich-396	22	17	integrity	integrity	NOUN
biomedich-396	22	18	and	and	CCONJ
biomedich-396	22	19	shield	shield	VERB
biomedich-396	22	20	the	the	DET
biomedich-396	22	21	bacillus	bacillus	NOUN
biomedich-396	22	22	from	from	ADP
biomedich-396	22	23	oxidative	oxidative	ADJ
biomedich-396	22	24	stress	stress	NOUN
biomedich-396	22	25	(	(	PUNCT
biomedich-396	22	26	takayama	takayama	PROPN
biomedich-396	22	27	et	et	PROPN
biomedich-396	22	28	al	al	PROPN
biomedich-396	22	29	,	,	PUNCT
biomedich-396	22	30	2005	2005	NUM
biomedich-396	22	31	)	)	PUNCT
biomedich-396	22	32	.	.	PUNCT
biomedich-396	23	1	the	the	DET
biomedich-396	23	2	development	development	NOUN
biomedich-396	23	3	of	of	ADP
biomedich-396	23	4	an	an	DET
biomedich-396	23	5	immune	immune	ADJ
biomedich-396	23	6	response	response	NOUN
biomedich-396	23	7	is	be	AUX
biomedich-396	23	8	necessary	necessary	ADJ
biomedich-396	23	9	for	for	ADP
biomedich-396	23	10	the	the	DET
biomedich-396	23	11	control	control	NOUN
biomedich-396	23	12	of	of	ADP
biomedich-396	23	13	mtb	mtb	NOUN
biomedich-396	23	14	infection	infection	NOUN
biomedich-396	23	15	in	in	ADP
biomedich-396	23	16	individuals	individual	NOUN
biomedich-396	23	17	who	who	PRON
biomedich-396	23	18	are	be	AUX
biomedich-396	23	19	resistant	resistant	ADJ
biomedich-396	23	20	to	to	ADP
biomedich-396	23	21	the	the	DET
biomedich-396	23	22	infection	infection	NOUN
biomedich-396	23	23	.	.	PUNCT
biomedich-396	24	1	this	this	DET
biomedich-396	24	2	type	type	NOUN
biomedich-396	24	3	of	of	ADP
biomedich-396	24	4	response	response	NOUN
biomedich-396	24	5	entails	entail	VERB
biomedich-396	24	6	the	the	DET
biomedich-396	24	7	involvement	involvement	NOUN
biomedich-396	24	8	of	of	ADP
biomedich-396	24	9	resident	resident	ADJ
biomedich-396	24	10	alveolar	alveolar	ADJ
biomedich-396	24	11	macrophages	macrophage	NOUN
biomedich-396	24	12	,	,	PUNCT
biomedich-396	24	13	dendritic	dendritic	ADJ
biomedich-396	24	14	cells	cell	NOUN
biomedich-396	24	15	,	,	PUNCT
biomedich-396	24	16	t	t	PROPN
biomedich-396	24	17	lymphocytes	lymphocyte	NOUN
biomedich-396	24	18	(	(	PUNCT
biomedich-396	24	19	tcd4	tcd4	PROPN
biomedich-396	24	20	+	+	PROPN
biomedich-396	24	21	,	,	PUNCT
biomedich-396	24	22	tcd8	tcd8	ADJ
biomedich-396	24	23	+	+	NUM
biomedich-396	24	24	cells	cell	NOUN
biomedich-396	24	25	)	)	PUNCT
biomedich-396	24	26	and	and	CCONJ
biomedich-396	24	27	the	the	DET
biomedich-396	24	28	release	release	NOUN
biomedich-396	24	29	of	of	ADP
biomedich-396	24	30	proinflammatory	proinflammatory	ADJ
biomedich-396	24	31	cytokines	cytokine	NOUN
biomedich-396	24	32	such	such	ADJ
biomedich-396	24	33	as	as	ADP
biomedich-396	24	34	interferon	interferon	ADJ
biomedich-396	24	35	-	-	PUNCT
biomedich-396	24	36	gamma	gamma	NOUN
biomedich-396	24	37	(	(	PUNCT
biomedich-396	24	38	ifn	ifn	PROPN
biomedich-396	24	39	γ	γ	X
biomedich-396	24	40	)	)	PUNCT
biomedich-396	24	41	,	,	PUNCT
biomedich-396	24	42	interleukin-2	interleukin-2	NOUN
biomedich-396	24	43	(	(	PUNCT
biomedich-396	24	44	il-2	il-2	NUM
biomedich-396	24	45	)	)	PUNCT
biomedich-396	24	46	,	,	PUNCT
biomedich-396	24	47	il-12	il-12	NOUN
biomedich-396	24	48	,	,	PUNCT
biomedich-396	24	49	il-18	il-18	ADP
biomedich-396	24	50	,	,	PUNCT
biomedich-396	24	51	and	and	CCONJ
biomedich-396	24	52	tumor	tumor	NOUN
biomedich-396	24	53	necrosis	necrosis	NOUN
biomedich-396	24	54	factor	factor	NOUN
biomedich-396	24	55	–	–	PUNCT
biomedich-396	24	56	alpha	alpha	NOUN
biomedich-396	24	57	(	(	PUNCT
biomedich-396	24	58	tnfα	tnfα	NOUN
biomedich-396	24	59	)	)	PUNCT
biomedich-396	24	60	.	.	PUNCT
biomedich-396	25	1	all	all	PRON
biomedich-396	25	2	of	of	ADP
biomedich-396	25	3	these	these	PRON
biomedich-396	25	4	are	be	AUX
biomedich-396	25	5	crucial	crucial	ADJ
biomedich-396	25	6	for	for	ADP
biomedich-396	25	7	attracting	attract	VERB
biomedich-396	25	8	more	more	ADJ
biomedich-396	25	9	immune	immune	ADJ
biomedich-396	25	10	cells	cell	NOUN
biomedich-396	25	11	to	to	ADP
biomedich-396	25	12	the	the	DET
biomedich-396	25	13	infection	infection	NOUN
biomedich-396	25	14	site	site	NOUN
biomedich-396	25	15	to	to	PART
biomedich-396	25	16	create	create	VERB
biomedich-396	25	17	a	a	DET
biomedich-396	25	18	granuloma	granuloma	NOUN
biomedich-396	25	19	that	that	SCONJ
biomedich-396	25	20	traps	trap	NOUN
biomedich-396	25	21	and	and	CCONJ
biomedich-396	25	22	destroys	destroy	VERB
biomedich-396	25	23	tuberculosis	tuberculosis	PRON
biomedich-396	25	24	bacilli	bacilli	NOUN
biomedich-396	25	25	while	while	SCONJ
biomedich-396	25	26	also	also	ADV
biomedich-396	25	27	providing	provide	VERB
biomedich-396	25	28	the	the	DET
biomedich-396	25	29	long	long	ADJ
biomedich-396	25	30	-	-	PUNCT
biomedich-396	25	31	term	term	NOUN
biomedich-396	25	32	niche	niche	NOUN
biomedich-396	25	33	required	require	VERB
biomedich-396	25	34	for	for	ADP
biomedich-396	25	35	latent	latent	NOUN
biomedich-396	25	36	tuberculosis	tuberculosis	NOUN
biomedich-396	25	37	infection	infection	NOUN
biomedich-396	25	38	(	(	PUNCT
biomedich-396	25	39	druszczyńska	druszczyńska	X
biomedich-396	25	40	,	,	PUNCT
biomedich-396	25	41	kowalewicz	kowalewicz	NOUN
biomedich-396	25	42	-	-	PUNCT
biomedich-396	25	43	kulbat	kulbat	PROPN
biomedich-396	25	44	,	,	PUNCT
biomedich-396	25	45	fol	fol	NOUN
biomedich-396	25	46	,	,	PUNCT
biomedich-396	25	47	włodarczyk	włodarczyk	NOUN
biomedich-396	25	48	,	,	PUNCT
biomedich-396	25	49	&	&	CCONJ
biomedich-396	25	50	rudnicka	rudnicka	NOUN
biomedich-396	25	51	,	,	PUNCT
biomedich-396	25	52	2012	2012	NUM
biomedich-396	25	53	)	)	PUNCT
biomedich-396	25	54	.	.	PUNCT
biomedich-396	26	1	if	if	SCONJ
biomedich-396	26	2	the	the	DET
biomedich-396	26	3	ongoing	ongoing	ADJ
biomedich-396	26	4	bacterial	bacterial	ADJ
biomedich-396	26	5	reproduction	reproduction	NOUN
biomedich-396	26	6	is	be	AUX
biomedich-396	26	7	not	not	PART
biomedich-396	26	8	stopped	stop	VERB
biomedich-396	26	9	,	,	PUNCT
biomedich-396	26	10	the	the	DET
biomedich-396	26	11	bacilli	bacilli	NOUN
biomedich-396	26	12	and	and	CCONJ
biomedich-396	26	13	expanding	expand	VERB
biomedich-396	26	14	tubercle	tubercle	NOUN
biomedich-396	26	15	may	may	AUX
biomedich-396	26	16	invade	invade	VERB
biomedich-396	26	17	the	the	DET
biomedich-396	26	18	nearby	nearby	ADJ
biomedich-396	26	19	draining	drain	VERB
biomedich-396	26	20	lymph	lymph	NOUN
biomedich-396	26	21	nodes	node	NOUN
biomedich-396	26	22	.	.	PUNCT
biomedich-396	27	1	as	as	ADP
biomedich-396	27	2	a	a	DET
biomedich-396	27	3	result	result	NOUN
biomedich-396	27	4	,	,	PUNCT
biomedich-396	27	5	lymphadenopathy	lymphadenopathy	ADJ
biomedich-396	27	6	develops	develop	VERB
biomedich-396	27	7	,	,	PUNCT
biomedich-396	27	8	which	which	PRON
biomedich-396	27	9	is	be	AUX
biomedich-396	27	10	a	a	DET
biomedich-396	27	11	typical	typical	ADJ
biomedich-396	27	12	sign	sign	NOUN
biomedich-396	27	13	of	of	ADP
biomedich-396	27	14	primary	primary	ADJ
biomedich-396	27	15	tb	tb	NOUN
biomedich-396	27	16	.	.	PUNCT
biomedich-396	28	1	if	if	SCONJ
biomedich-396	28	2	the	the	DET
biomedich-396	28	3	lesion	lesion	NOUN
biomedich-396	28	4	caused	cause	VERB
biomedich-396	28	5	by	by	ADP
biomedich-396	28	6	the	the	DET
biomedich-396	28	7	tubercle	tubercle	NOUN
biomedich-396	28	8	's	's	PART
biomedich-396	28	9	expansion	expansion	NOUN
biomedich-396	28	10	progresses	progress	VERB
biomedich-396	28	11	to	to	ADP
biomedich-396	28	12	the	the	DET
biomedich-396	28	13	lymph	lymph	NOUN
biomedich-396	28	14	node	node	NOUN
biomedich-396	28	15	and	and	CCONJ
biomedich-396	28	16	lung	lung	NOUN
biomedich-396	28	17	parenchyma	parenchyma	NOUN
biomedich-396	28	18	,	,	PUNCT
biomedich-396	28	19	a	a	DET
biomedich-396	28	20	ghon	ghon	ADJ
biomedich-396	28	21	complex	complex	NOUN
biomedich-396	28	22	may	may	AUX
biomedich-396	28	23	form	form	VERB
biomedich-396	28	24	.	.	PUNCT
biomedich-396	29	1	the	the	DET
biomedich-396	29	2	ghon	ghon	ADJ
biomedich-396	29	3	focus	focus	NOUN
biomedich-396	29	4	,	,	PUNCT
biomedich-396	29	5	which	which	PRON
biomedich-396	29	6	describes	describe	VERB
biomedich-396	29	7	the	the	DET
biomedich-396	29	8	main	main	ADJ
biomedich-396	29	9	tb	tb	NOUN
biomedich-396	29	10	infection	infection	NOUN
biomedich-396	29	11	,	,	PUNCT
biomedich-396	29	12	is	be	AUX
biomedich-396	29	13	often	often	ADV
biomedich-396	29	14	seen	see	VERB
biomedich-396	29	15	in	in	ADP
biomedich-396	29	16	the	the	DET
biomedich-396	29	17	center	center	NOUN
biomedich-396	29	18	of	of	ADP
biomedich-396	29	19	the	the	DET
biomedich-396	29	20	lungs	lung	NOUN
biomedich-396	29	21	and	and	CCONJ
biomedich-396	29	22	is	be	AUX
biomedich-396	29	23	a	a	DET
biomedich-396	29	24	hallmark	hallmark	NOUN
biomedich-396	29	25	of	of	ADP
biomedich-396	29	26	tb	tb	ADP
biomedich-396	29	27	manuscript	manuscript	NOUN
biomedich-396	29	28	received	receive	VERB
biomedich-396	29	29	:	:	PUNCT
biomedich-396	29	30	22	22	NUM
biomedich-396	29	31	july	july	PROPN
biomedich-396	29	32	,	,	PUNCT
biomedich-396	29	33	2023	2023	NUM
biomedich-396	29	34	.	.	PUNCT
biomedich-396	30	1	revision	revision	NOUN
biomedich-396	30	2	accepted	accept	VERB
biomedich-396	30	3	:	:	PUNCT
biomedich-396	30	4	08	08	NUM
biomedich-396	30	5	august	august	PROPN
biomedich-396	30	6	,	,	PUNCT
biomedich-396	30	7	2023	2023	NUM
biomedich-396	30	8	.	.	PUNCT
biomedich-396	31	1	published	publish	VERB
biomedich-396	31	2	:	:	PUNCT
biomedich-396	31	3	14	14	NUM
biomedich-396	31	4	august	august	PROPN
biomedich-396	31	5	,	,	PUNCT
biomedich-396	31	6	2023	2023	NUM
biomedich-396	31	7	.	.	PUNCT
biomedich-396	32	1	https://doi.org/10.14421/biomedich.2023.122.441-450	https://doi.org/10.14421/biomedich.2023.122.441-450	NUM
biomedich-396	32	2	442	442	NUM
biomedich-396	32	3	biology	biology	NOUN
biomedich-396	32	4	,	,	PUNCT
biomedich-396	32	5	medicine	medicine	NOUN
biomedich-396	32	6	,	,	PUNCT
biomedich-396	32	7	&	&	CCONJ
biomedich-396	32	8	natural	natural	ADJ
biomedich-396	32	9	product	product	NOUN
biomedich-396	32	10	chemistry	chemistry	NOUN
biomedich-396	32	11	12	12	NUM
biomedich-396	32	12	(	(	PUNCT
biomedich-396	32	13	2	2	NUM
biomedich-396	32	14	)	)	PUNCT
biomedich-396	32	15	,	,	PUNCT
biomedich-396	32	16	2023	2023	NUM
biomedich-396	32	17	:	:	PUNCT
biomedich-396	32	18	441	441	NUM
biomedich-396	32	19	-	-	SYM
biomedich-396	32	20	450	450	NUM
biomedich-396	32	21	infection	infection	NOUN
biomedich-396	32	22	.	.	PUNCT
biomedich-396	33	1	latent	latent	NOUN
biomedich-396	33	2	tb	tb	PROPN
biomedich-396	33	3	reactivates	reactivate	VERB
biomedich-396	33	4	into	into	ADP
biomedich-396	33	5	active	active	ADJ
biomedich-396	33	6	tuberculosis	tuberculosis	NOUN
biomedich-396	33	7	in	in	ADP
biomedich-396	33	8	the	the	DET
biomedich-396	33	9	presence	presence	NOUN
biomedich-396	33	10	of	of	ADP
biomedich-396	33	11	immunosuppression	immunosuppression	NOUN
biomedich-396	33	12	in	in	ADP
biomedich-396	33	13	the	the	DET
biomedich-396	33	14	host	host	NOUN
biomedich-396	33	15	(	(	PUNCT
biomedich-396	33	16	ruiru	ruiru	PROPN
biomedich-396	33	17	&	&	CCONJ
biomedich-396	33	18	isamu	isamu	PROPN
biomedich-396	33	19	,	,	PUNCT
biomedich-396	33	20	2013	2013	NUM
biomedich-396	33	21	)	)	PUNCT
biomedich-396	33	22	.	.	PUNCT
biomedich-396	34	1	changes	change	NOUN
biomedich-396	34	2	in	in	ADP
biomedich-396	34	3	the	the	DET
biomedich-396	34	4	host	host	NOUN
biomedich-396	34	5	's	's	PART
biomedich-396	34	6	physiological	physiological	ADJ
biomedich-396	34	7	and	and	CCONJ
biomedich-396	34	8	immunological	immunological	ADJ
biomedich-396	34	9	condition	condition	NOUN
biomedich-396	34	10	brought	bring	VERB
biomedich-396	34	11	on	on	ADP
biomedich-396	34	12	by	by	ADP
biomedich-396	34	13	aging	aging	NOUN
biomedich-396	34	14	,	,	PUNCT
biomedich-396	34	15	malnutrition	malnutrition	NOUN
biomedich-396	34	16	,	,	PUNCT
biomedich-396	34	17	diabetes	diabetes	NOUN
biomedich-396	34	18	or	or	CCONJ
biomedich-396	34	19	the	the	DET
biomedich-396	34	20	emergence	emergence	NOUN
biomedich-396	34	21	of	of	ADP
biomedich-396	34	22	other	other	ADJ
biomedich-396	34	23	illnesses	illness	NOUN
biomedich-396	34	24	,	,	PUNCT
biomedich-396	34	25	including	include	VERB
biomedich-396	34	26	hiv	hiv	PROPN
biomedich-396	34	27	/	/	SYM
biomedich-396	34	28	aids	aids	PROPN
biomedich-396	34	29	,	,	PUNCT
biomedich-396	34	30	as	as	ADV
biomedich-396	34	31	well	well	ADV
biomedich-396	34	32	as	as	ADP
biomedich-396	34	33	latent	latent	NOUN
biomedich-396	34	34	infections	infection	NOUN
biomedich-396	34	35	,	,	PUNCT
biomedich-396	34	36	might	might	AUX
biomedich-396	34	37	trigger	trigger	VERB
biomedich-396	34	38	their	their	PRON
biomedich-396	34	39	activation	activation	NOUN
biomedich-396	34	40	.	.	PUNCT
biomedich-396	35	1	the	the	DET
biomedich-396	35	2	use	use	NOUN
biomedich-396	35	3	of	of	ADP
biomedich-396	35	4	many	many	ADJ
biomedich-396	35	5	antibiotics	antibiotic	NOUN
biomedich-396	35	6	given	give	VERB
biomedich-396	35	7	over	over	ADP
biomedich-396	35	8	the	the	DET
biomedich-396	35	9	course	course	NOUN
biomedich-396	35	10	of	of	ADP
biomedich-396	35	11	six	six	NUM
biomedich-396	35	12	months	month	NOUN
biomedich-396	35	13	is	be	AUX
biomedich-396	35	14	required	require	VERB
biomedich-396	35	15	for	for	ADP
biomedich-396	35	16	chemotherapy	chemotherapy	NOUN
biomedich-396	35	17	for	for	ADP
biomedich-396	35	18	active	active	ADJ
biomedich-396	35	19	tb	tb	NOUN
biomedich-396	35	20	caused	cause	VERB
biomedich-396	35	21	by	by	ADP
biomedich-396	35	22	drugsensitive	drugsensitive	ADJ
biomedich-396	35	23	bacteria	bacteria	NOUN
biomedich-396	35	24	.	.	PUNCT
biomedich-396	36	1	patient	patient	ADJ
biomedich-396	36	2	compliance	compliance	NOUN
biomedich-396	36	3	is	be	AUX
biomedich-396	36	4	typically	typically	ADV
biomedich-396	36	5	low	low	ADJ
biomedich-396	36	6	as	as	ADP
biomedich-396	36	7	a	a	DET
biomedich-396	36	8	result	result	NOUN
biomedich-396	36	9	of	of	ADP
biomedich-396	36	10	this	this	DET
biomedich-396	36	11	difficult	difficult	ADJ
biomedich-396	36	12	and	and	CCONJ
biomedich-396	36	13	potentially	potentially	ADV
biomedich-396	36	14	hazardous	hazardous	ADJ
biomedich-396	36	15	treatment	treatment	NOUN
biomedich-396	36	16	regimen	regiman	NOUN
biomedich-396	36	17	.	.	PUNCT
biomedich-396	37	1	as	as	ADP
biomedich-396	37	2	a	a	DET
biomedich-396	37	3	result	result	NOUN
biomedich-396	37	4	,	,	PUNCT
biomedich-396	37	5	antibiotic	antibiotic	ADJ
biomedich-396	37	6	-	-	PUNCT
biomedich-396	37	7	resistant	resistant	ADJ
biomedich-396	37	8	bacteria	bacteria	NOUN
biomedich-396	37	9	have	have	AUX
biomedich-396	37	10	developed	develop	VERB
biomedich-396	37	11	,	,	PUNCT
biomedich-396	37	12	necessitating	necessitate	VERB
biomedich-396	37	13	lengthier	lengthy	ADJ
biomedich-396	37	14	treatment	treatment	NOUN
biomedich-396	37	15	regimens	regimen	NOUN
biomedich-396	37	16	,	,	PUNCT
biomedich-396	37	17	the	the	DET
biomedich-396	37	18	use	use	NOUN
biomedich-396	37	19	of	of	ADP
biomedich-396	37	20	less	less	ADV
biomedich-396	37	21	effective	effective	ADJ
biomedich-396	37	22	and	and	CCONJ
biomedich-396	37	23	more	more	ADV
biomedich-396	37	24	toxic	toxic	ADJ
biomedich-396	37	25	medications	medication	NOUN
biomedich-396	37	26	,	,	PUNCT
biomedich-396	37	27	and	and	CCONJ
biomedich-396	37	28	increasing	increase	VERB
biomedich-396	37	29	failure	failure	NOUN
biomedich-396	37	30	rates	rate	NOUN
biomedich-396	37	31	(	(	PUNCT
biomedich-396	37	32	reddy	reddy	PROPN
biomedich-396	37	33	et	et	PROPN
biomedich-396	37	34	al	al	PROPN
biomedich-396	37	35	.	.	PROPN
biomedich-396	37	36	,	,	PUNCT
biomedich-396	37	37	2008	2008	NUM
biomedich-396	37	38	)	)	PUNCT
biomedich-396	37	39	.	.	PUNCT
biomedich-396	38	1	the	the	DET
biomedich-396	38	2	aim	aim	NOUN
biomedich-396	38	3	of	of	ADP
biomedich-396	38	4	this	this	DET
biomedich-396	38	5	study	study	NOUN
biomedich-396	38	6	is	be	AUX
biomedich-396	38	7	to	to	PART
biomedich-396	38	8	analyze	analyze	VERB
biomedich-396	38	9	the	the	DET
biomedich-396	38	10	anti	anti	ADJ
biomedich-396	38	11	-	-	ADJ
biomedich-396	38	12	tb	tb	ADJ
biomedich-396	38	13	effects	effect	NOUN
biomedich-396	38	14	of	of	ADP
biomedich-396	38	15	several	several	ADJ
biomedich-396	38	16	natural	natural	ADJ
biomedich-396	38	17	alkaloids	alkaloid	NOUN
biomedich-396	38	18	and	and	CCONJ
biomedich-396	38	19	their	their	PRON
biomedich-396	38	20	potential	potential	NOUN
biomedich-396	38	21	to	to	PART
biomedich-396	38	22	weaken	weaken	VERB
biomedich-396	38	23	the	the	DET
biomedich-396	38	24	pathogenesis	pathogenesis	NOUN
biomedich-396	38	25	of	of	ADP
biomedich-396	38	26	tuberculosis	tuberculosis	NOUN
biomedich-396	38	27	using	use	VERB
biomedich-396	38	28	in	in	ADP
biomedich-396	38	29	-	-	PUNCT
biomedich-396	38	30	silico	silico	NOUN
biomedich-396	38	31	tools	tool	NOUN
biomedich-396	38	32	.	.	PUNCT
biomedich-396	39	1	in	in	ADP
biomedich-396	39	2	order	order	NOUN
biomedich-396	39	3	predict	predict	VERB
biomedich-396	39	4	the	the	DET
biomedich-396	39	5	potential	potential	ADJ
biomedich-396	39	6	activity	activity	NOUN
biomedich-396	39	7	of	of	ADP
biomedich-396	39	8	alkaloids	alkaloid	NOUN
biomedich-396	39	9	against	against	ADP
biomedich-396	39	10	the	the	DET
biomedich-396	39	11	active	active	ADJ
biomedich-396	39	12	tb	tb	ADP
biomedich-396	39	13	infection	infection	NOUN
biomedich-396	39	14	,	,	PUNCT
biomedich-396	39	15	this	this	DET
biomedich-396	39	16	study	study	NOUN
biomedich-396	39	17	utilized	utilize	VERB
biomedich-396	39	18	molecular	molecular	ADJ
biomedich-396	39	19	docking	docking	NOUN
biomedich-396	39	20	and	and	CCONJ
biomedich-396	39	21	molecular	molecular	ADJ
biomedich-396	39	22	dynamics	dynamic	NOUN
biomedich-396	39	23	simulation	simulation	NOUN
biomedich-396	39	24	as	as	ADP
biomedich-396	39	25	methodological	methodological	ADJ
biomedich-396	39	26	techniques	technique	NOUN
biomedich-396	39	27	.	.	PUNCT
biomedich-396	40	1	the	the	DET
biomedich-396	40	2	pathophysiology	pathophysiology	NOUN
biomedich-396	40	3	of	of	ADP
biomedich-396	40	4	tuberculosis	tuberculosis	NOUN
biomedich-396	40	5	infection	infection	NOUN
biomedich-396	40	6	is	be	AUX
biomedich-396	40	7	depicted	depict	VERB
biomedich-396	40	8	in	in	ADP
biomedich-396	40	9	figure	figure	NOUN
biomedich-396	40	10	1	1	NUM
biomedich-396	40	11	.	.	PUNCT
biomedich-396	40	12	figure	figure	NOUN
biomedich-396	40	13	1	1	NUM
biomedich-396	40	14	.	.	PUNCT
biomedich-396	41	1	the	the	DET
biomedich-396	41	2	figure	figure	NOUN
biomedich-396	41	3	illustrates	illustrate	VERB
biomedich-396	41	4	the	the	DET
biomedich-396	41	5	pathogenesis	pathogenesis	NOUN
biomedich-396	41	6	of	of	ADP
biomedich-396	41	7	tuberculosis	tuberculosis	NOUN
biomedich-396	41	8	infection	infection	NOUN
biomedich-396	41	9	caused	cause	VERB
biomedich-396	41	10	by	by	ADP
biomedich-396	41	11	mycobacterium	mycobacterium	NOUN
biomedich-396	41	12	tuberculosis	tuberculosis	NOUN
biomedich-396	41	13	.	.	PUNCT
biomedich-396	42	1	material	material	NOUN
biomedich-396	42	2	and	and	CCONJ
biomedich-396	42	3	methods	method	NOUN
biomedich-396	42	4	macromolecule	macromolecule	NOUN
biomedich-396	42	5	preparation	preparation	NOUN
biomedich-396	42	6	rcsb	rcsb	NOUN
biomedich-396	42	7	(	(	PUNCT
biomedich-396	42	8	protein	protein	NOUN
biomedich-396	42	9	data	data	PROPN
biomedich-396	42	10	bank	bank	PROPN
biomedich-396	42	11	)	)	PUNCT
biomedich-396	42	12	was	be	AUX
biomedich-396	42	13	used	use	VERB
biomedich-396	42	14	to	to	PART
biomedich-396	42	15	retrieve	retrieve	VERB
biomedich-396	42	16	the	the	DET
biomedich-396	42	17	3d	3d	NUM
biomedich-396	42	18	structure	structure	NOUN
biomedich-396	42	19	of	of	ADP
biomedich-396	42	20	mycobacterial	mycobacterial	ADJ
biomedich-396	42	21	acp	acp	PROPN
biomedich-396	42	22	(	(	PUNCT
biomedich-396	42	23	acyl	acyl	NOUN
biomedich-396	42	24	carrier	carrier	NOUN
biomedich-396	42	25	protein	protein	NOUN
biomedich-396	42	26	)	)	PUNCT
biomedich-396	42	27	reductase	reductase	NOUN
biomedich-396	42	28	enzyme	enzyme	NOUN
biomedich-396	42	29	(	(	PUNCT
biomedich-396	42	30	pdb	pdb	PROPN
biomedich-396	42	31	i	i	PROPN
biomedich-396	42	32	d	d	PROPN
biomedich-396	42	33	:	:	PUNCT
biomedich-396	42	34	4r9s	4r9s	NUM
biomedich-396	42	35	)	)	PUNCT
biomedich-396	42	36	in	in	ADP
biomedich-396	42	37	protein	protein	NOUN
biomedich-396	42	38	data	datum	NOUN
biomedich-396	42	39	bank	bank	PROPN
biomedich-396	42	40	(	(	PUNCT
biomedich-396	42	41	pdb	pdb	NOUN
biomedich-396	42	42	)	)	PUNCT
biomedich-396	42	43	format	format	NOUN
biomedich-396	42	44	.	.	PUNCT
biomedich-396	43	1	pdb	pdb	PROPN
biomedich-396	43	2	contains	contain	VERB
biomedich-396	43	3	the	the	DET
biomedich-396	43	4	structure	structure	NOUN
biomedich-396	43	5	elucidation	elucidation	NOUN
biomedich-396	43	6	data	datum	NOUN
biomedich-396	43	7	of	of	ADP
biomedich-396	43	8	proteins	protein	NOUN
biomedich-396	43	9	obtained	obtain	VERB
biomedich-396	43	10	by	by	ADP
biomedich-396	43	11	x	x	NOUN
biomedich-396	43	12	-	-	NOUN
biomedich-396	43	13	ray	ray	NOUN
biomedich-396	43	14	crystallography	crystallography	NOUN
biomedich-396	43	15	and	and	CCONJ
biomedich-396	43	16	nuclear	nuclear	ADJ
biomedich-396	43	17	magnetic	magnetic	ADJ
biomedich-396	43	18	resonance	resonance	NOUN
biomedich-396	43	19	(	(	PUNCT
biomedich-396	43	20	nmr	nmr	NOUN
biomedich-396	43	21	)	)	PUNCT
biomedich-396	43	22	spectrometry	spectrometry	NOUN
biomedich-396	43	23	submitted	submit	VERB
biomedich-396	43	24	by	by	ADP
biomedich-396	43	25	biologists	biologist	NOUN
biomedich-396	43	26	and	and	CCONJ
biomedich-396	43	27	biochemists	biochemist	NOUN
biomedich-396	43	28	from	from	ADP
biomedich-396	43	29	all	all	ADV
biomedich-396	43	30	over	over	ADP
biomedich-396	43	31	the	the	DET
biomedich-396	43	32	world	world	NOUN
biomedich-396	43	33	.	.	PUNCT
biomedich-396	44	1	macromolecule	macromolecule	NOUN
biomedich-396	44	2	was	be	AUX
biomedich-396	44	3	prepared	prepare	VERB
biomedich-396	44	4	by	by	ADP
biomedich-396	44	5	removing	remove	VERB
biomedich-396	44	6	water	water	NOUN
biomedich-396	44	7	molecules	molecule	NOUN
biomedich-396	44	8	,	,	PUNCT
biomedich-396	44	9	heteroatoms	heteroatom	NOUN
biomedich-396	44	10	,	,	PUNCT
biomedich-396	44	11	ligands	ligand	NOUN
biomedich-396	44	12	,	,	PUNCT
biomedich-396	44	13	extra	extra	ADJ
biomedich-396	44	14	protein	protein	NOUN
biomedich-396	44	15	chains	chain	NOUN
biomedich-396	44	16	,	,	PUNCT
biomedich-396	44	17	and	and	CCONJ
biomedich-396	44	18	metal	metal	NOUN
biomedich-396	44	19	ions	ion	NOUN
biomedich-396	44	20	that	that	PRON
biomedich-396	44	21	could	could	AUX
biomedich-396	44	22	interact	interact	VERB
biomedich-396	44	23	with	with	ADP
biomedich-396	44	24	compounds	compound	NOUN
biomedich-396	44	25	during	during	ADP
biomedich-396	44	26	visualization	visualization	NOUN
biomedich-396	44	27	of	of	ADP
biomedich-396	44	28	docking	docking	NOUN
biomedich-396	44	29	between	between	ADP
biomedich-396	44	30	compounds	compound	NOUN
biomedich-396	44	31	and	and	CCONJ
biomedich-396	44	32	target	target	NOUN
biomedich-396	44	33	proteins	protein	NOUN
biomedich-396	44	34	using	use	VERB
biomedich-396	44	35	biovia	biovia	PROPN
biomedich-396	44	36	discovery	discovery	PROPN
biomedich-396	44	37	studio	studio	PROPN
biomedich-396	44	38	visualizer	visualizer	PROPN
biomedich-396	44	39	v17.2.0.16349	v17.2.0.16349	NOUN
biomedich-396	44	40	(	(	PUNCT
biomedich-396	44	41	sharma	sharma	PROPN
biomedich-396	44	42	et	et	PROPN
biomedich-396	44	43	al	al	PROPN
biomedich-396	44	44	,	,	PUNCT
biomedich-396	44	45	2021	2021	NUM
biomedich-396	44	46	)	)	PUNCT
biomedich-396	44	47	.	.	PUNCT
biomedich-396	45	1	ligand	ligand	PROPN
biomedich-396	45	2	preparation	preparation	NOUN
biomedich-396	45	3	the	the	DET
biomedich-396	45	4	compounds	compound	NOUN
biomedich-396	45	5	used	use	VERB
biomedich-396	45	6	as	as	ADP
biomedich-396	45	7	ligands	ligand	NOUN
biomedich-396	45	8	for	for	ADP
biomedich-396	45	9	the	the	DET
biomedich-396	45	10	antimicrobial	antimicrobial	ADJ
biomedich-396	45	11	activity	activity	NOUN
biomedich-396	45	12	were	be	AUX
biomedich-396	45	13	from	from	ADP
biomedich-396	45	14	the	the	DET
biomedich-396	45	15	alkaloidal	alkaloidal	ADJ
biomedich-396	45	16	class	class	NOUN
biomedich-396	45	17	of	of	ADP
biomedich-396	45	18	phytochemicals	phytochemical	NOUN
biomedich-396	45	19	.	.	PUNCT
biomedich-396	46	1	the	the	DET
biomedich-396	46	2	structures	structure	NOUN
biomedich-396	46	3	of	of	ADP
biomedich-396	46	4	these	these	DET
biomedich-396	46	5	compounds	compound	NOUN
biomedich-396	46	6	were	be	AUX
biomedich-396	46	7	downloaded	download	VERB
biomedich-396	46	8	from	from	ADP
biomedich-396	46	9	the	the	DET
biomedich-396	46	10	pubchem	pubchem	NOUN
biomedich-396	46	11	database	database	NOUN
biomedich-396	46	12	and	and	CCONJ
biomedich-396	46	13	chem3d	chem3d	NOUN
biomedich-396	46	14	16.0	16.0	NUM
biomedich-396	46	15	was	be	AUX
biomedich-396	46	16	used	use	VERB
biomedich-396	46	17	to	to	PART
biomedich-396	46	18	obtain	obtain	VERB
biomedich-396	46	19	the	the	DET
biomedich-396	46	20	pdb	pdb	NOUN
biomedich-396	46	21	format	format	NOUN
biomedich-396	46	22	of	of	ADP
biomedich-396	46	23	these	these	DET
biomedich-396	46	24	3dstructured	3dstructured	NUM
biomedich-396	46	25	compounds	compound	NOUN
biomedich-396	46	26	.	.	PUNCT
biomedich-396	47	1	c1	c1	PROPN
biomedich-396	47	2	(	(	PUNCT
biomedich-396	47	3	protopine	protopine	NOUN
biomedich-396	47	4	)	)	PUNCT
biomedich-396	47	5	,	,	PUNCT
biomedich-396	47	6	c2	c2	PROPN
biomedich-396	47	7	(	(	PUNCT
biomedich-396	47	8	apropine	apropine	NOUN
biomedich-396	47	9	)	)	PUNCT
biomedich-396	47	10	,	,	PUNCT
biomedich-396	47	11	c3	c3	PROPN
biomedich-396	47	12	(	(	PUNCT
biomedich-396	47	13	avicine	avicine	NOUN
biomedich-396	47	14	)	)	PUNCT
biomedich-396	47	15	,	,	PUNCT
biomedich-396	47	16	c4	c4	NOUN
biomedich-396	47	17	(	(	PUNCT
biomedich-396	47	18	penduline	penduline	NOUN
biomedich-396	47	19	)	)	PUNCT
biomedich-396	47	20	,	,	PUNCT
biomedich-396	47	21	and	and	CCONJ
biomedich-396	47	22	c5	c5	PROPN
biomedich-396	47	23	(	(	PUNCT
biomedich-396	47	24	chelerythrine	chelerythrine	NOUN
biomedich-396	47	25	)	)	PUNCT
biomedich-396	47	26	were	be	AUX
biomedich-396	47	27	used	use	VERB
biomedich-396	47	28	to	to	PART
biomedich-396	47	29	study	study	VERB
biomedich-396	47	30	the	the	DET
biomedich-396	47	31	potential	potential	ADJ
biomedich-396	47	32	inhibition	inhibition	NOUN
biomedich-396	47	33	of	of	ADP
biomedich-396	47	34	mycobacterial	mycobacterial	ADJ
biomedich-396	47	35	acyl	acyl	NOUN
biomedich-396	47	36	carrier	carrier	NOUN
biomedich-396	47	37	protein	protein	NOUN
biomedich-396	47	38	reductase	reductase	NOUN
biomedich-396	47	39	for	for	ADP
biomedich-396	47	40	preventing	prevent	VERB
biomedich-396	47	41	tuberculosis	tuberculosis	PRON
biomedich-396	47	42	infection	infection	NOUN
biomedich-396	47	43	.	.	PUNCT
biomedich-396	48	1	these	these	DET
biomedich-396	48	2	five	five	NUM
biomedich-396	48	3	compounds	compound	NOUN
biomedich-396	48	4	were	be	AUX
biomedich-396	48	5	used	use	VERB
biomedich-396	48	6	against	against	ADP
biomedich-396	48	7	the	the	DET
biomedich-396	48	8	target	target	NOUN
biomedich-396	48	9	protein	protein	NOUN
biomedich-396	48	10	to	to	PART
biomedich-396	48	11	check	check	VERB
biomedich-396	48	12	the	the	DET
biomedich-396	48	13	interaction	interaction	NOUN
biomedich-396	48	14	of	of	ADP
biomedich-396	48	15	the	the	DET
biomedich-396	48	16	target	target	NOUN
biomedich-396	48	17	protein	protein	NOUN
biomedich-396	48	18	with	with	ADP
biomedich-396	48	19	these	these	DET
biomedich-396	48	20	compounds	compound	NOUN
biomedich-396	48	21	(	(	PUNCT
biomedich-396	48	22	c1c5	c1c5	NOUN
biomedich-396	48	23	)	)	PUNCT
biomedich-396	48	24	.	.	PUNCT
biomedich-396	49	1	figure	figure	NOUN
biomedich-396	49	2	2	2	NUM
biomedich-396	49	3	shows	show	VERB
biomedich-396	49	4	the	the	DET
biomedich-396	49	5	graphical	graphical	ADJ
biomedich-396	49	6	representation	representation	NOUN
biomedich-396	49	7	of	of	ADP
biomedich-396	49	8	the	the	DET
biomedich-396	49	9	complete	complete	ADJ
biomedich-396	49	10	methodology	methodology	NOUN
biomedich-396	49	11	of	of	ADP
biomedich-396	49	12	the	the	DET
biomedich-396	49	13	research	research	NOUN
biomedich-396	49	14	study	study	NOUN
biomedich-396	49	15	.	.	PUNCT
biomedich-396	50	1	kamran	kamran	PROPN
biomedich-396	50	2	&	&	CCONJ
biomedich-396	50	3	ibrahim	ibrahim	PROPN
biomedich-396	50	4	–	–	PUNCT
biomedich-396	50	5	alkaloids	alkaloid	NOUN
biomedich-396	50	6	lead	lead	VERB
biomedich-396	50	7	to	to	ADP
biomedich-396	50	8	potential	potential	ADJ
biomedich-396	50	9	inhibition	inhibition	NOUN
biomedich-396	50	10	of	of	ADP
biomedich-396	50	11	the	the	PRON
biomedich-396	50	12	…	…	PUNCT
biomedich-396	50	13	443	443	NUM
biomedich-396	50	14	the	the	DET
biomedich-396	50	15	chemical	chemical	NOUN
biomedich-396	50	16	structures	structure	NOUN
biomedich-396	50	17	and	and	CCONJ
biomedich-396	50	18	botanical	botanical	ADJ
biomedich-396	50	19	sources	source	NOUN
biomedich-396	50	20	of	of	ADP
biomedich-396	50	21	compounds	compound	NOUN
biomedich-396	50	22	(	(	PUNCT
biomedich-396	50	23	c1	c1	PROPN
biomedich-396	50	24	c5	c5	PROPN
biomedich-396	50	25	)	)	PUNCT
biomedich-396	50	26	are	be	AUX
biomedich-396	50	27	provided	provide	VERB
biomedich-396	50	28	in	in	ADP
biomedich-396	50	29	table	table	NOUN
biomedich-396	50	30	1	1	NUM
biomedich-396	50	31	while	while	SCONJ
biomedich-396	50	32	figure	figure	VERB
biomedich-396	50	33	3	3	NUM
biomedich-396	50	34	depicts	depict	VERB
biomedich-396	50	35	the	the	DET
biomedich-396	50	36	iupac	iupac	ADJ
biomedich-396	50	37	names	name	NOUN
biomedich-396	50	38	of	of	ADP
biomedich-396	50	39	the	the	DET
biomedich-396	50	40	compounds	compound	NOUN
biomedich-396	50	41	c1	c1	PROPN
biomedich-396	50	42	–	–	PUNCT
biomedich-396	50	43	c5	c5	PROPN
biomedich-396	50	44	.	.	PUNCT
biomedich-396	51	1	figure	figure	NOUN
biomedich-396	51	2	2	2	NUM
biomedich-396	51	3	.	.	PUNCT
biomedich-396	52	1	the	the	DET
biomedich-396	52	2	figure	figure	NOUN
biomedich-396	52	3	shows	show	VERB
biomedich-396	52	4	the	the	DET
biomedich-396	52	5	step	step	NOUN
biomedich-396	52	6	by	by	ADP
biomedich-396	52	7	step	step	NOUN
biomedich-396	52	8	methodology	methodology	NOUN
biomedich-396	52	9	of	of	ADP
biomedich-396	52	10	the	the	DET
biomedich-396	52	11	research	research	NOUN
biomedich-396	52	12	study	study	NOUN
biomedich-396	52	13	.	.	PUNCT
biomedich-396	53	1	table	table	NOUN
biomedich-396	53	2	1	1	NUM
biomedich-396	53	3	.	.	PUNCT
biomedich-396	54	1	the	the	DET
biomedich-396	54	2	table	table	NOUN
biomedich-396	54	3	shows	show	VERB
biomedich-396	54	4	the	the	DET
biomedich-396	54	5	names	name	NOUN
biomedich-396	54	6	of	of	ADP
biomedich-396	54	7	alkaloids	alkaloid	NOUN
biomedich-396	54	8	employed	employ	VERB
biomedich-396	54	9	in	in	ADP
biomedich-396	54	10	this	this	DET
biomedich-396	54	11	study	study	NOUN
biomedich-396	54	12	,	,	PUNCT
biomedich-396	54	13	their	their	PRON
biomedich-396	54	14	pubchem	pubchem	NOUN
biomedich-396	54	15	i	i	PROPN
biomedich-396	54	16	d	d	PROPN
biomedich-396	54	17	,	,	PUNCT
biomedich-396	54	18	chemical	chemical	NOUN
biomedich-396	54	19	structures	structure	NOUN
biomedich-396	54	20	and	and	CCONJ
biomedich-396	54	21	botanical	botanical	ADJ
biomedich-396	54	22	sources	source	NOUN
biomedich-396	54	23	.	.	PUNCT
biomedich-396	55	1	compound	compound	NOUN
biomedich-396	55	2	compound	compound	PROPN
biomedich-396	55	3	name	name	PROPN
biomedich-396	55	4	pubchem	pubchem	NOUN
biomedich-396	55	5	i	i	PROPN
biomedich-396	55	6	d	d	PROPN
biomedich-396	55	7	structure	structure	PROPN
biomedich-396	55	8	botanical	botanical	PROPN
biomedich-396	55	9	source	source	PROPN
biomedich-396	55	10	literature	literature	PROPN
biomedich-396	55	11	source	source	PROPN
biomedich-396	55	12	c1	c1	PROPN
biomedich-396	55	13	protopine	protopine	PROPN
biomedich-396	55	14	4970	4970	NUM
biomedich-396	55	15	corydalis	corydali	VERB
biomedich-396	55	16	heterocarpa	heterocarpa	PROPN
biomedich-396	55	17	var	var	PROPN
biomedich-396	55	18	.	.	PUNCT
biomedich-396	56	1	japonica	japonica	PROPN
biomedich-396	56	2	pubchem	pubchem	PROPN
biomedich-396	56	3	c2	c2	PROPN
biomedich-396	56	4	aporphine	aporphine	PROPN
biomedich-396	56	5	114911	114911	PROPN
biomedich-396	56	6	antizoma	antizoma	PROPN
biomedich-396	56	7	angustifolia	angustifolia	PROPN
biomedich-396	56	8	pubchem	pubchem	PROPN
biomedich-396	56	9	c3	c3	PROPN
biomedich-396	56	10	avicine	avicine	VERB
biomedich-396	56	11	356657	356657	NUM
biomedich-396	56	12	zanthoxylum	zanthoxylum	PROPN
biomedich-396	56	13	asiaticum	asiaticum	PROPN
biomedich-396	56	14	pubchem	pubchem	NOUN
biomedich-396	56	15	c4	c4	NOUN
biomedich-396	56	16	penduline	penduline	NOUN
biomedich-396	56	17	179472	179472	NUM
biomedich-396	56	18	leptopus	leptopus	PROPN
biomedich-396	56	19	cordifolius	cordifolius	NOUN
biomedich-396	56	20	pubchem	pubchem	NOUN
biomedich-396	56	21	c5	c5	PROPN
biomedich-396	56	22	chelerythrine	chelerythrine	NOUN
biomedich-396	56	23	2703	2703	NUM
biomedich-396	56	24	zanthoxylum	zanthoxylum	PROPN
biomedich-396	56	25	fagara	fagara	PROPN
biomedich-396	56	26	pubchem	pubchem	NOUN
biomedich-396	56	27	444	444	NUM
biomedich-396	56	28	biology	biology	NOUN
biomedich-396	56	29	,	,	PUNCT
biomedich-396	56	30	medicine	medicine	NOUN
biomedich-396	56	31	,	,	PUNCT
biomedich-396	56	32	&	&	CCONJ
biomedich-396	56	33	natural	natural	ADJ
biomedich-396	56	34	product	product	NOUN
biomedich-396	56	35	chemistry	chemistry	NOUN
biomedich-396	56	36	12	12	NUM
biomedich-396	56	37	(	(	PUNCT
biomedich-396	56	38	2	2	NUM
biomedich-396	56	39	)	)	PUNCT
biomedich-396	56	40	,	,	PUNCT
biomedich-396	56	41	2023	2023	NUM
biomedich-396	56	42	:	:	PUNCT
biomedich-396	56	43	441	441	NUM
biomedich-396	56	44	-	-	SYM
biomedich-396	56	45	450	450	NUM
biomedich-396	56	46	figure	figure	NOUN
biomedich-396	56	47	3	3	NUM
biomedich-396	56	48	.	.	PUNCT
biomedich-396	57	1	the	the	DET
biomedich-396	57	2	figure	figure	NOUN
biomedich-396	57	3	demonstrates	demonstrate	VERB
biomedich-396	57	4	the	the	DET
biomedich-396	57	5	chemical	chemical	NOUN
biomedich-396	57	6	structures	structure	NOUN
biomedich-396	57	7	of	of	ADP
biomedich-396	57	8	compounds	compound	NOUN
biomedich-396	57	9	c1	c1	PROPN
biomedich-396	57	10	to	to	ADP
biomedich-396	57	11	c5	c5	PROPN
biomedich-396	57	12	,	,	PUNCT
biomedich-396	57	13	along	along	ADP
biomedich-396	57	14	with	with	ADP
biomedich-396	57	15	their	their	PRON
biomedich-396	57	16	iupac	iupac	NOUN
biomedich-396	57	17	names	name	NOUN
biomedich-396	57	18	obtained	obtain	VERB
biomedich-396	57	19	from	from	ADP
biomedich-396	57	20	pubchem	pubchem	NOUN
biomedich-396	57	21	.	.	PUNCT
biomedich-396	58	1	results	result	NOUN
biomedich-396	58	2	and	and	CCONJ
biomedich-396	58	3	discussion	discussion	NOUN
biomedich-396	58	4	molecular	molecular	ADJ
biomedich-396	58	5	docking	docking	NOUN
biomedich-396	58	6	analysis	analysis	NOUN
biomedich-396	58	7	&	&	CCONJ
biomedich-396	58	8	results	result	NOUN
biomedich-396	58	9	in	in	ADP
biomedich-396	58	10	structural	structural	ADJ
biomedich-396	58	11	molecular	molecular	ADJ
biomedich-396	58	12	biology	biology	NOUN
biomedich-396	58	13	,	,	PUNCT
biomedich-396	58	14	medicinal	medicinal	ADJ
biomedich-396	58	15	chemistry	chemistry	NOUN
biomedich-396	58	16	and	and	CCONJ
biomedich-396	58	17	computer	computer	NOUN
biomedich-396	58	18	-	-	PUNCT
biomedich-396	58	19	assisted	assist	VERB
biomedich-396	58	20	drug	drug	NOUN
biomedich-396	58	21	development	development	NOUN
biomedich-396	58	22	,	,	PUNCT
biomedich-396	58	23	molecular	molecular	ADJ
biomedich-396	58	24	docking	docking	NOUN
biomedich-396	58	25	is	be	AUX
biomedich-396	58	26	a	a	DET
biomedich-396	58	27	useful	useful	ADJ
biomedich-396	58	28	technique	technique	NOUN
biomedich-396	58	29	.	.	PUNCT
biomedich-396	59	1	predicting	predict	VERB
biomedich-396	59	2	the	the	DET
biomedich-396	59	3	prevailing	prevail	VERB
biomedich-396	59	4	binding	bind	VERB
biomedich-396	59	5	modes	mode	NOUN
biomedich-396	59	6	and	and	CCONJ
biomedich-396	59	7	poses	pose	NOUN
biomedich-396	59	8	of	of	ADP
biomedich-396	59	9	a	a	DET
biomedich-396	59	10	compound	compound	NOUN
biomedich-396	59	11	that	that	PRON
biomedich-396	59	12	interacts	interact	VERB
biomedich-396	59	13	with	with	ADP
biomedich-396	59	14	a	a	DET
biomedich-396	59	15	protein	protein	NOUN
biomedich-396	59	16	having	have	VERB
biomedich-396	59	17	a	a	DET
biomedich-396	59	18	known	know	VERB
biomedich-396	59	19	three	three	NUM
biomedich-396	59	20	-	-	PUNCT
biomedich-396	59	21	dimensional	dimensional	ADJ
biomedich-396	59	22	structure	structure	NOUN
biomedich-396	59	23	is	be	AUX
biomedich-396	59	24	the	the	DET
biomedich-396	59	25	major	major	ADJ
biomedich-396	59	26	aim	aim	NOUN
biomedich-396	59	27	of	of	ADP
biomedich-396	59	28	compound	compound	NOUN
biomedich-396	59	29	-	-	PUNCT
biomedich-396	59	30	protein	protein	NOUN
biomedich-396	59	31	docking	docking	NOUN
biomedich-396	59	32	.	.	PUNCT
biomedich-396	60	1	successful	successful	ADJ
biomedich-396	60	2	docking	docking	NOUN
biomedich-396	60	3	methods	method	NOUN
biomedich-396	60	4	employ	employ	VERB
biomedich-396	60	5	a	a	DET
biomedich-396	60	6	scoring	scoring	NOUN
biomedich-396	60	7	system	system	NOUN
biomedich-396	60	8	that	that	PRON
biomedich-396	60	9	accurately	accurately	ADV
biomedich-396	60	10	ranks	rank	VERB
biomedich-396	60	11	the	the	DET
biomedich-396	60	12	drug	drug	NOUN
biomedich-396	60	13	candidate	candidate	NOUN
biomedich-396	60	14	dockings	docking	NOUN
biomedich-396	60	15	and	and	CCONJ
biomedich-396	60	16	efficiently	efficiently	ADV
biomedich-396	60	17	explores	explore	VERB
biomedich-396	60	18	binding	bind	VERB
biomedich-396	60	19	affinities	affinity	NOUN
biomedich-396	60	20	and	and	CCONJ
biomedich-396	60	21	best	good	ADJ
biomedich-396	60	22	poses	pose	NOUN
biomedich-396	60	23	.	.	PUNCT
biomedich-396	61	1	lead	lead	VERB
biomedich-396	61	2	optimization	optimization	NOUN
biomedich-396	61	3	greatly	greatly	ADV
biomedich-396	61	4	benefits	benefit	VERB
biomedich-396	61	5	from	from	ADP
biomedich-396	61	6	the	the	DET
biomedich-396	61	7	use	use	NOUN
biomedich-396	61	8	of	of	ADP
biomedich-396	61	9	docking	docking	NOUN
biomedich-396	61	10	to	to	PART
biomedich-396	61	11	do	do	VERB
biomedich-396	61	12	virtual	virtual	ADJ
biomedich-396	61	13	screening	screening	NOUN
biomedich-396	61	14	to	to	PART
biomedich-396	61	15	provide	provide	VERB
biomedich-396	61	16	insights	insight	NOUN
biomedich-396	61	17	for	for	ADP
biomedich-396	61	18	how	how	SCONJ
biomedich-396	61	19	the	the	DET
biomedich-396	61	20	ligands	ligand	NOUN
biomedich-396	61	21	interfere	interfere	VERB
biomedich-396	61	22	with	with	ADP
biomedich-396	61	23	the	the	DET
biomedich-396	61	24	target	target	NOUN
biomedich-396	61	25	(	(	PUNCT
biomedich-396	61	26	fan	fan	NOUN
biomedich-396	61	27	,	,	PUNCT
biomedich-396	61	28	fu	fu	PROPN
biomedich-396	61	29	,	,	PUNCT
biomedich-396	61	30	&	&	CCONJ
biomedich-396	61	31	zhang	zhang	PROPN
biomedich-396	61	32	,	,	PUNCT
biomedich-396	61	33	2019	2019	NUM
biomedich-396	61	34	)	)	PUNCT
biomedich-396	61	35	.	.	PUNCT
biomedich-396	62	1	pyrx	pyrx	PROPN
biomedich-396	62	2	was	be	AUX
biomedich-396	62	3	utilized	utilize	VERB
biomedich-396	62	4	for	for	ADP
biomedich-396	62	5	this	this	DET
biomedich-396	62	6	experiment	experiment	NOUN
biomedich-396	62	7	.	.	PUNCT
biomedich-396	63	1	pyrx	pyrx	NOUN
biomedich-396	63	2	includes	include	VERB
biomedich-396	63	3	a	a	DET
biomedich-396	63	4	docking	docking	NOUN
biomedich-396	63	5	wizard	wizard	NOUN
biomedich-396	63	6	with	with	ADP
biomedich-396	63	7	an	an	DET
biomedich-396	63	8	easy	easy	ADJ
biomedich-396	63	9	-	-	PUNCT
biomedich-396	63	10	to	to	ADP
biomedich-396	63	11	-	-	PUNCT
biomedich-396	63	12	use	use	NOUN
biomedich-396	63	13	user	user	NOUN
biomedich-396	63	14	interface	interface	NOUN
biomedich-396	63	15	,	,	PUNCT
biomedich-396	63	16	which	which	PRON
biomedich-396	63	17	makes	make	VERB
biomedich-396	63	18	it	it	PRON
biomedich-396	63	19	a	a	DET
biomedich-396	63	20	valuable	valuable	ADJ
biomedich-396	63	21	tool	tool	NOUN
biomedich-396	63	22	for	for	ADP
biomedich-396	63	23	computeraided	computeraide	VERB
biomedich-396	63	24	drug	drug	NOUN
biomedich-396	63	25	design	design	NOUN
biomedich-396	63	26	(	(	PUNCT
biomedich-396	63	27	cadd	cadd	NOUN
biomedich-396	63	28	)	)	PUNCT
biomedich-396	63	29	.	.	PUNCT
biomedich-396	64	1	pyrx	pyrx	NOUN
biomedich-396	64	2	also	also	ADV
biomedich-396	64	3	includes	include	VERB
biomedich-396	64	4	chemical	chemical	NOUN
biomedich-396	64	5	spreadsheet	spreadsheet	NOUN
biomedich-396	64	6	-	-	PUNCT
biomedich-396	64	7	like	like	ADJ
biomedich-396	64	8	functionality	functionality	NOUN
biomedich-396	64	9	that	that	PRON
biomedich-396	64	10	helps	help	VERB
biomedich-396	64	11	in	in	ADP
biomedich-396	64	12	novel	novel	ADJ
biomedich-396	64	13	drug	drug	NOUN
biomedich-396	64	14	molecule	molecule	NOUN
biomedich-396	64	15	designing	designing	NOUN
biomedich-396	64	16	(	(	PUNCT
biomedich-396	64	17	dallakyan	dallakyan	PROPN
biomedich-396	64	18	&	&	CCONJ
biomedich-396	64	19	olson	olson	PROPN
biomedich-396	64	20	,	,	PUNCT
biomedich-396	64	21	2015	2015	NUM
biomedich-396	64	22	)	)	PUNCT
biomedich-396	64	23	.	.	PUNCT
biomedich-396	65	1	software	software	NOUN
biomedich-396	65	2	version	version	PROPN
biomedich-396	65	3	17.2.0.16349	17.2.0.16349	PROPN
biomedich-396	65	4	of	of	ADP
biomedich-396	65	5	biovia	biovia	PROPN
biomedich-396	65	6	discovery	discovery	PROPN
biomedich-396	65	7	studio	studio	PROPN
biomedich-396	65	8	visualizer	visualizer	NOUN
biomedich-396	65	9	was	be	AUX
biomedich-396	65	10	used	use	VERB
biomedich-396	65	11	.	.	PUNCT
biomedich-396	66	1	it	it	PRON
biomedich-396	66	2	offered	offer	VERB
biomedich-396	66	3	a	a	DET
biomedich-396	66	4	clear	clear	ADJ
biomedich-396	66	5	depiction	depiction	NOUN
biomedich-396	66	6	of	of	ADP
biomedich-396	66	7	the	the	DET
biomedich-396	66	8	2d	2d	NOUN
biomedich-396	66	9	and	and	CCONJ
biomedich-396	66	10	3d	3d	NUM
biomedich-396	66	11	interactions	interaction	NOUN
biomedich-396	66	12	as	as	ADV
biomedich-396	66	13	well	well	ADV
biomedich-396	66	14	as	as	ADP
biomedich-396	66	15	bond	bond	NOUN
biomedich-396	66	16	lengths	length	NOUN
biomedich-396	66	17	,	,	PUNCT
biomedich-396	66	18	aromatic	aromatic	NOUN
biomedich-396	66	19	,	,	PUNCT
biomedich-396	66	20	hydrophobic	hydrophobic	NOUN
biomedich-396	66	21	,	,	PUNCT
biomedich-396	66	22	and	and	CCONJ
biomedich-396	66	23	other	other	ADJ
biomedich-396	66	24	interactions	interaction	NOUN
biomedich-396	66	25	.	.	PUNCT
biomedich-396	67	1	results	result	NOUN
biomedich-396	67	2	from	from	ADP
biomedich-396	67	3	the	the	DET
biomedich-396	67	4	molecular	molecular	ADJ
biomedich-396	67	5	docking	docking	NOUN
biomedich-396	67	6	studies	study	NOUN
biomedich-396	67	7	of	of	ADP
biomedich-396	67	8	the	the	DET
biomedich-396	67	9	mycobacterial	mycobacterial	ADJ
biomedich-396	67	10	acp	acp	PROPN
biomedich-396	67	11	protein	protein	NOUN
biomedich-396	67	12	with	with	ADP
biomedich-396	67	13	compounds	compound	NOUN
biomedich-396	67	14	c1	c1	PROPN
biomedich-396	67	15	–	–	PUNCT
biomedich-396	67	16	c5	c5	PROPN
biomedich-396	67	17	were	be	AUX
biomedich-396	67	18	valuable	valuable	ADJ
biomedich-396	67	19	,	,	PUNCT
biomedich-396	67	20	as	as	SCONJ
biomedich-396	67	21	shown	show	VERB
biomedich-396	67	22	in	in	ADP
biomedich-396	67	23	table	table	NOUN
biomedich-396	67	24	2	2	NUM
biomedich-396	67	25	.	.	PUNCT
biomedich-396	67	26	table	table	NOUN
biomedich-396	67	27	2	2	NUM
biomedich-396	67	28	.	.	PUNCT
biomedich-396	68	1	the	the	DET
biomedich-396	68	2	table	table	NOUN
biomedich-396	68	3	shows	show	VERB
biomedich-396	68	4	the	the	DET
biomedich-396	68	5	findings	finding	NOUN
biomedich-396	68	6	and	and	CCONJ
biomedich-396	68	7	results	result	NOUN
biomedich-396	68	8	of	of	ADP
biomedich-396	68	9	the	the	DET
biomedich-396	68	10	molecular	molecular	ADJ
biomedich-396	68	11	docking	docking	NOUN
biomedich-396	68	12	analysis	analysis	NOUN
biomedich-396	68	13	done	do	VERB
biomedich-396	68	14	using	use	VERB
biomedich-396	68	15	compounds	compound	NOUN
biomedich-396	68	16	c1	c1	PROPN
biomedich-396	68	17	to	to	ADP
biomedich-396	68	18	c5	c5	PROPN
biomedich-396	68	19	.	.	PUNCT
biomedich-396	69	1	compound	compound	NOUN
biomedich-396	69	2	-	-	PUNCT
biomedich-396	69	3	protein	protein	NOUN
biomedich-396	69	4	interaction	interaction	NOUN
biomedich-396	69	5	binding	bind	VERB
biomedich-396	69	6	energy	energy	NOUN
biomedich-396	69	7	(	(	PUNCT
biomedich-396	69	8	kcal	kcal	NOUN
biomedich-396	69	9	/	/	SYM
biomedich-396	69	10	mol	mol	NOUN
biomedich-396	69	11	)	)	PUNCT
biomedich-396	69	12	bonding	bonding	NOUN
biomedich-396	69	13	residues	residue	NOUN
biomedich-396	69	14	type	type	NOUN
biomedich-396	69	15	of	of	ADP
biomedich-396	69	16	bond	bond	NOUN
biomedich-396	69	17	bond	bond	NOUN
biomedich-396	69	18	length	length	NOUN
biomedich-396	69	19	(	(	PUNCT
biomedich-396	69	20	å	å	NOUN
biomedich-396	69	21	)	)	PUNCT
biomedich-396	69	22	other	other	ADJ
biomedich-396	69	23	residues	residue	NOUN
biomedich-396	69	24	c1	c1	NOUN
biomedich-396	69	25	-10	-10	PUNCT
biomedich-396	69	26	phe	phe	PROPN
biomedich-396	69	27	41	41	NUM
biomedich-396	69	28	pi	pi	NOUN
biomedich-396	69	29	pi	pi	PROPN
biomedich-396	69	30	4.55	4.55	NUM
biomedich-396	69	31	ile	ile	PROPN
biomedich-396	69	32	15	15	NUM
biomedich-396	69	33	ile	ile	NOUN
biomedich-396	69	34	95	95	NUM
biomedich-396	69	35	pi	pi	NOUN
biomedich-396	69	36	sigma	sigma	PROPN
biomedich-396	69	37	3.41	3.41	NUM
biomedich-396	69	38	thr	thr	PROPN
biomedich-396	69	39	39	39	NUM
biomedich-396	69	40	carbon	carbon	NOUN
biomedich-396	69	41	hydrogen	hydrogen	NOUN
biomedich-396	69	42	3.64	3.64	NUM
biomedich-396	69	43	c2	c2	PROPN
biomedich-396	69	44	-9.8	-9.8	PROPN
biomedich-396	69	45	phe	phe	PROPN
biomedich-396	69	46	41	41	NUM
biomedich-396	69	47	pi	pi	NOUN
biomedich-396	69	48	pi	pi	NOUN
biomedich-396	69	49	stacked	stack	VERB
biomedich-396	69	50	3.74	3.74	NUM
biomedich-396	69	51	val	val	NOUN
biomedich-396	69	52	65	65	NUM
biomedich-396	69	53	,	,	PUNCT
biomedich-396	69	54	ile	ile	PROPN
biomedich-396	69	55	122	122	NUM
biomedich-396	69	56	.	.	PUNCT
biomedich-396	70	1	ile	ile	PROPN
biomedich-396	70	2	95	95	NUM
biomedich-396	70	3	pi	pi	NOUN
biomedich-396	70	4	alkyl	alkyl	NOUN
biomedich-396	70	5	5.23	5.23	NUM
biomedich-396	70	6	c3	c3	NOUN
biomedich-396	70	7	-9.7	-9.7	ADP
biomedich-396	70	8	phe	phe	PROPN
biomedich-396	70	9	41	41	NUM
biomedich-396	70	10	pi	pi	NOUN
biomedich-396	70	11	pi	pi	NOUN
biomedich-396	70	12	stacked	stack	VERB
biomedich-396	70	13	4.26	4.26	NUM
biomedich-396	70	14	ile	ile	PROPN
biomedich-396	70	15	122	122	NUM
biomedich-396	70	16	,	,	PUNCT
biomedich-396	70	17	ile	ile	PROPN
biomedich-396	70	18	16	16	NUM
biomedich-396	70	19	ile	ile	NOUN
biomedich-396	70	20	95	95	NUM
biomedich-396	70	21	pi	pi	NOUN
biomedich-396	70	22	sigma	sigma	PROPN
biomedich-396	70	23	3.86	3.86	NUM
biomedich-396	70	24	asp	asp	NOUN
biomedich-396	70	25	64	64	NUM
biomedich-396	70	26	carbon	carbon	NOUN
biomedich-396	70	27	hydrogen	hydrogen	NOUN
biomedich-396	70	28	3.27	3.27	NUM
biomedich-396	70	29	ser	ser	NOUN
biomedich-396	70	30	20	20	NUM
biomedich-396	70	31	conventional	conventional	ADJ
biomedich-396	70	32	hydrogen	hydrogen	NOUN
biomedich-396	70	33	bond	bond	NOUN
biomedich-396	70	34	2.87	2.87	NUM
biomedich-396	70	35	c4	c4	NOUN
biomedich-396	70	36	-9.6	-9.6	PROPN
biomedich-396	70	37	phe	phe	NOUN
biomedich-396	70	38	97	97	NUM
biomedich-396	70	39	pi	pi	NOUN
biomedich-396	70	40	pi	pi	PROPN
biomedich-396	70	41	t	t	PROPN
biomedich-396	70	42	shaped	shape	VERB
biomedich-396	70	43	5.92	5.92	NUM
biomedich-396	70	44	leu	leu	PROPN
biomedich-396	70	45	207	207	NUM
biomedich-396	70	46	,	,	PUNCT
biomedich-396	70	47	met	meet	VERB
biomedich-396	70	48	103	103	NUM
biomedich-396	70	49	,	,	PUNCT
biomedich-396	70	50	ile	ile	PROPN
biomedich-396	70	51	21	21	NUM
biomedich-396	70	52	,	,	PUNCT
biomedich-396	71	1	leu	leu	PROPN
biomedich-396	71	2	207	207	NUM
biomedich-396	71	3	ile	ile	PROPN
biomedich-396	71	4	16	16	NUM
biomedich-396	71	5	pi	pi	NOUN
biomedich-396	71	6	sigma	sigma	PROPN
biomedich-396	71	7	4.00	4.00	NUM
biomedich-396	71	8	c5	c5	PROPN
biomedich-396	71	9	-9.1	-9.1	PROPN
biomedich-396	71	10	phe	phe	PROPN
biomedich-396	71	11	41	41	NUM
biomedich-396	71	12	pi	pi	NOUN
biomedich-396	71	13	pi	pi	NOUN
biomedich-396	71	14	stacked	stack	VERB
biomedich-396	71	15	4.30	4.30	NUM
biomedich-396	71	16	gly	gly	NOUN
biomedich-396	71	17	14	14	NUM
biomedich-396	71	18	,	,	PUNCT
biomedich-396	71	19	ile	ile	PROPN
biomedich-396	71	20	122	122	NUM
biomedich-396	71	21	,	,	PUNCT
biomedich-396	71	22	phe	phe	PROPN
biomedich-396	71	23	97	97	NUM
biomedich-396	72	1	ile	ile	NOUN
biomedich-396	72	2	16	16	NUM
biomedich-396	72	3	pi	pi	NOUN
biomedich-396	72	4	sigma	sigma	PROPN
biomedich-396	72	5	3.78	3.78	NUM
biomedich-396	72	6	asp	asp	PROPN
biomedich-396	72	7	64	64	NUM
biomedich-396	72	8	carbon	carbon	NOUN
biomedich-396	72	9	hydrogen	hydrogen	NOUN
biomedich-396	72	10	bond	bond	NOUN
biomedich-396	72	11	3.44	3.44	NUM
biomedich-396	72	12	ser	ser	NOUN
biomedich-396	72	13	20	20	NUM
biomedich-396	72	14	conventional	conventional	ADJ
biomedich-396	72	15	hydrogen	hydrogen	NOUN
biomedich-396	72	16	bond	bond	NOUN
biomedich-396	72	17	3.26	3.26	NUM
biomedich-396	72	18	kamran	kamran	PROPN
biomedich-396	72	19	&	&	CCONJ
biomedich-396	72	20	ibrahim	ibrahim	PROPN
biomedich-396	72	21	–	–	PUNCT
biomedich-396	72	22	alkaloids	alkaloid	NOUN
biomedich-396	72	23	lead	lead	VERB
biomedich-396	72	24	to	to	ADP
biomedich-396	72	25	potential	potential	ADJ
biomedich-396	72	26	inhibition	inhibition	NOUN
biomedich-396	72	27	of	of	ADP
biomedich-396	72	28	the	the	DET
biomedich-396	72	29	…	…	PUNCT
biomedich-396	72	30	445	445	NUM
biomedich-396	72	31	all	all	DET
biomedich-396	72	32	the	the	DET
biomedich-396	72	33	compounds	compound	NOUN
biomedich-396	72	34	c1	c1	PROPN
biomedich-396	72	35	to	to	ADP
biomedich-396	72	36	c5	c5	PROPN
biomedich-396	72	37	,	,	PUNCT
biomedich-396	72	38	exhibited	exhibit	VERB
biomedich-396	72	39	their	their	PRON
biomedich-396	72	40	firm	firm	ADJ
biomedich-396	72	41	interactions	interaction	NOUN
biomedich-396	72	42	with	with	ADP
biomedich-396	72	43	the	the	DET
biomedich-396	72	44	binding	bind	VERB
biomedich-396	72	45	site	site	NOUN
biomedich-396	72	46	residues	residue	NOUN
biomedich-396	72	47	of	of	ADP
biomedich-396	72	48	mycobacterial	mycobacterial	ADJ
biomedich-396	72	49	acp	acp	PROPN
biomedich-396	72	50	reductase	reductase	NOUN
biomedich-396	72	51	enzyme	enzyme	NOUN
biomedich-396	72	52	receptor	receptor	NOUN
biomedich-396	72	53	i.e.	i.e.	ADV
biomedich-396	72	54	,	,	PUNCT
biomedich-396	72	55	phe	phe	NOUN
biomedich-396	72	56	41	41	NUM
biomedich-396	72	57	,	,	PUNCT
biomedich-396	72	58	ile	ile	PROPN
biomedich-396	72	59	95	95	NUM
biomedich-396	72	60	,	,	PUNCT
biomedich-396	72	61	ile	ile	PROPN
biomedich-396	72	62	16	16	NUM
biomedich-396	72	63	and	and	CCONJ
biomedich-396	72	64	ser	ser	NOUN
biomedich-396	72	65	20	20	NUM
biomedich-396	72	66	with	with	ADP
biomedich-396	72	67	a	a	DET
biomedich-396	72	68	binding	bind	VERB
biomedich-396	72	69	pose	pose	NOUN
biomedich-396	72	70	ranging	range	VERB
biomedich-396	72	71	from	from	ADP
biomedich-396	72	72	–	–	PUNCT
biomedich-396	72	73	10	10	NUM
biomedich-396	72	74	to	to	ADP
biomedich-396	72	75	-9.1	-9.1	PROPN
biomedich-396	72	76	kcal	kcal	PROPN
biomedich-396	72	77	/	/	SYM
biomedich-396	72	78	mol	mol	PROPN
biomedich-396	72	79	.	.	PUNCT
biomedich-396	73	1	the	the	DET
biomedich-396	73	2	best	good	ADJ
biomedich-396	73	3	binding	binding	NOUN
biomedich-396	73	4	pose	pose	VERB
biomedich-396	73	5	with	with	ADP
biomedich-396	73	6	binding	bind	VERB
biomedich-396	73	7	energy	energy	NOUN
biomedich-396	73	8	of	of	ADP
biomedich-396	73	9	–	–	PUNCT
biomedich-396	73	10	10	10	NUM
biomedich-396	73	11	kcal	kcal	NOUN
biomedich-396	73	12	/	/	SYM
biomedich-396	73	13	mol	mol	PROPN
biomedich-396	73	14	was	be	AUX
biomedich-396	73	15	expressed	express	VERB
biomedich-396	73	16	by	by	ADP
biomedich-396	73	17	protopine	protopine	PROPN
biomedich-396	73	18	(	(	PUNCT
biomedich-396	73	19	c1	c1	PROPN
biomedich-396	73	20	)	)	PUNCT
biomedich-396	73	21	,	,	PUNCT
biomedich-396	73	22	while	while	SCONJ
biomedich-396	73	23	the	the	DET
biomedich-396	73	24	binding	bind	VERB
biomedich-396	73	25	energies	energy	NOUN
biomedich-396	73	26	exhibited	exhibit	VERB
biomedich-396	73	27	by	by	ADP
biomedich-396	73	28	other	other	ADJ
biomedich-396	73	29	compounds	compound	NOUN
biomedich-396	73	30	in	in	ADP
biomedich-396	73	31	this	this	DET
biomedich-396	73	32	study	study	NOUN
biomedich-396	73	33	were	be	AUX
biomedich-396	73	34	-9.8	-9.8	PROPN
biomedich-396	73	35	kcal	kcal	PROPN
biomedich-396	73	36	/	/	SYM
biomedich-396	73	37	mol	mol	PROPN
biomedich-396	73	38	for	for	ADP
biomedich-396	73	39	aporphine	aporphine	PROPN
biomedich-396	73	40	(	(	PUNCT
biomedich-396	73	41	c2	c2	PROPN
biomedich-396	73	42	)	)	PUNCT
biomedich-396	73	43	,	,	PUNCT
biomedich-396	73	44	-9.7	-9.7	PUNCT
biomedich-396	73	45	kcal	kcal	PROPN
biomedich-396	73	46	/	/	SYM
biomedich-396	73	47	mol	mol	PROPN
biomedich-396	73	48	for	for	ADP
biomedich-396	73	49	avicine	avicine	NOUN
biomedich-396	73	50	(	(	PUNCT
biomedich-396	73	51	c3),-9.6	c3),-9.6	PROPN
biomedich-396	73	52	kcal	kcal	PROPN
biomedich-396	73	53	/	/	SYM
biomedich-396	73	54	mol	mol	NOUN
biomedich-396	73	55	for	for	ADP
biomedich-396	73	56	penduline	penduline	NOUN
biomedich-396	73	57	(	(	PUNCT
biomedich-396	73	58	c4	c4	NOUN
biomedich-396	73	59	)	)	PUNCT
biomedich-396	73	60	and	and	CCONJ
biomedich-396	73	61	-9.1	-9.1	PROPN
biomedich-396	73	62	kcal	kcal	PROPN
biomedich-396	73	63	/	/	SYM
biomedich-396	73	64	mol	mol	NOUN
biomedich-396	73	65	for	for	ADP
biomedich-396	73	66	chelerythrine	chelerythrine	NOUN
biomedich-396	73	67	(	(	PUNCT
biomedich-396	73	68	c5).all	c5).all	NUM
biomedich-396	73	69	the	the	DET
biomedich-396	73	70	compounds	compound	NOUN
biomedich-396	73	71	showed	show	VERB
biomedich-396	73	72	absolute	absolute	ADJ
biomedich-396	73	73	interactions	interaction	NOUN
biomedich-396	73	74	with	with	ADP
biomedich-396	73	75	the	the	DET
biomedich-396	73	76	active	active	ADJ
biomedich-396	73	77	site	site	NOUN
biomedich-396	73	78	residues	residue	NOUN
biomedich-396	73	79	of	of	ADP
biomedich-396	73	80	mycobacterial	mycobacterial	ADJ
biomedich-396	73	81	acp	acp	PROPN
biomedich-396	73	82	reductase	reductase	NOUN
biomedich-396	73	83	enzyme	enzyme	NOUN
biomedich-396	73	84	.	.	PUNCT
biomedich-396	74	1	protopine	protopine	NOUN
biomedich-396	74	2	(	(	PUNCT
biomedich-396	74	3	c1	c1	PROPN
biomedich-396	74	4	)	)	PUNCT
biomedich-396	74	5	,	,	PUNCT
biomedich-396	74	6	aporphine	aporphine	PROPN
biomedich-396	74	7	(	(	PUNCT
biomedich-396	74	8	c2	c2	PROPN
biomedich-396	74	9	)	)	PUNCT
biomedich-396	74	10	,	,	PUNCT
biomedich-396	74	11	and	and	CCONJ
biomedich-396	74	12	avicine	avicine	NOUN
biomedich-396	74	13	(	(	PUNCT
biomedich-396	74	14	c3	c3	PROPN
biomedich-396	74	15	)	)	PUNCT
biomedich-396	74	16	were	be	AUX
biomedich-396	74	17	bound	bind	VERB
biomedich-396	74	18	to	to	PART
biomedich-396	74	19	phe	phe	PROPN
biomedich-396	74	20	41	41	NUM
biomedich-396	74	21	and	and	CCONJ
biomedich-396	74	22	ile	ile	PROPN
biomedich-396	74	23	95	95	NUM
biomedich-396	74	24	residues	residue	NOUN
biomedich-396	74	25	with	with	ADP
biomedich-396	74	26	lower	low	ADJ
biomedich-396	74	27	binding	bind	VERB
biomedich-396	74	28	energies	energy	NOUN
biomedich-396	74	29	.	.	PUNCT
biomedich-396	75	1	penduline	penduline	NOUN
biomedich-396	75	2	(	(	PUNCT
biomedich-396	75	3	c4	c4	NOUN
biomedich-396	75	4	)	)	PUNCT
biomedich-396	75	5	and	and	CCONJ
biomedich-396	75	6	chelerythrine	chelerythrine	NOUN
biomedich-396	75	7	(	(	PUNCT
biomedich-396	75	8	c5	c5	PROPN
biomedich-396	75	9	)	)	PUNCT
biomedich-396	75	10	manifested	manifest	VERB
biomedich-396	75	11	binding	bind	VERB
biomedich-396	75	12	with	with	ADP
biomedich-396	75	13	phe	phe	PROPN
biomedich-396	75	14	97	97	NUM
biomedich-396	75	15	,	,	PUNCT
biomedich-396	75	16	ile	ile	PROPN
biomedich-396	75	17	16	16	NUM
biomedich-396	75	18	,	,	PUNCT
biomedich-396	75	19	phe	phe	NOUN
biomedich-396	75	20	41	41	NUM
biomedich-396	75	21	,	,	PUNCT
biomedich-396	75	22	ile	ile	PROPN
biomedich-396	75	23	16	16	NUM
biomedich-396	75	24	,	,	PUNCT
biomedich-396	75	25	asp	asp	PROPN
biomedich-396	75	26	64	64	NUM
biomedich-396	75	27	,	,	PUNCT
biomedich-396	75	28	ser	ser	NOUN
biomedich-396	75	29	20	20	NUM
biomedich-396	75	30	residues	residue	NOUN
biomedich-396	75	31	with	with	ADP
biomedich-396	75	32	reasonable	reasonable	ADJ
biomedich-396	75	33	bond	bond	NOUN
biomedich-396	75	34	lengths	length	NOUN
biomedich-396	75	35	.	.	PUNCT
biomedich-396	76	1	compounds	compound	NOUN
biomedich-396	76	2	protopine	protopine	NOUN
biomedich-396	76	3	(	(	PUNCT
biomedich-396	76	4	c1	c1	PROPN
biomedich-396	76	5	)	)	PUNCT
biomedich-396	76	6	and	and	CCONJ
biomedich-396	76	7	aporphine	aporphine	PROPN
biomedich-396	76	8	(	(	PUNCT
biomedich-396	76	9	c2	c2	PROPN
biomedich-396	76	10	)	)	PUNCT
biomedich-396	76	11	also	also	ADV
biomedich-396	76	12	exhibited	exhibit	VERB
biomedich-396	76	13	firm	firm	ADJ
biomedich-396	76	14	interactions	interaction	NOUN
biomedich-396	76	15	with	with	ADP
biomedich-396	76	16	other	other	ADJ
biomedich-396	76	17	residues	residue	NOUN
biomedich-396	76	18	including	include	VERB
biomedich-396	76	19	ile	ile	PROPN
biomedich-396	76	20	15	15	NUM
biomedich-396	76	21	,	,	PUNCT
biomedich-396	76	22	val	val	NOUN
biomedich-396	76	23	65	65	NUM
biomedich-396	76	24	,	,	PUNCT
biomedich-396	76	25	and	and	CCONJ
biomedich-396	76	26	ile	ile	PROPN
biomedich-396	76	27	122	122	NUM
biomedich-396	76	28	,	,	PUNCT
biomedich-396	76	29	that	that	PRON
biomedich-396	76	30	may	may	AUX
biomedich-396	76	31	also	also	ADV
biomedich-396	76	32	be	be	AUX
biomedich-396	76	33	the	the	DET
biomedich-396	76	34	active	active	ADJ
biomedich-396	76	35	site	site	NOUN
biomedich-396	76	36	amino	amino	NOUN
biomedich-396	76	37	acid	acid	NOUN
biomedich-396	76	38	residues	residue	NOUN
biomedich-396	76	39	of	of	ADP
biomedich-396	76	40	mycobacterial	mycobacterial	ADJ
biomedich-396	76	41	acp	acp	PROPN
biomedich-396	76	42	reductase	reductase	NOUN
biomedich-396	76	43	enzyme	enzyme	NOUN
biomedich-396	76	44	.	.	PUNCT
biomedich-396	77	1	avicine	avicine	PROPN
biomedich-396	77	2	(	(	PUNCT
biomedich-396	77	3	c3	c3	PROPN
biomedich-396	77	4	)	)	PUNCT
biomedich-396	77	5	,	,	PUNCT
biomedich-396	77	6	penduline(c4	penduline(c4	NOUN
biomedich-396	77	7	)	)	PUNCT
biomedich-396	77	8	and	and	CCONJ
biomedich-396	77	9	chelerythrine	chelerythrine	NOUN
biomedich-396	77	10	(	(	PUNCT
biomedich-396	77	11	c5	c5	PROPN
biomedich-396	77	12	)	)	PUNCT
biomedich-396	77	13	demonstrated	demonstrate	VERB
biomedich-396	77	14	robust	robust	ADJ
biomedich-396	77	15	binding	bind	VERB
biomedich-396	77	16	affinities	affinity	NOUN
biomedich-396	77	17	with	with	ADP
biomedich-396	77	18	other	other	ADJ
biomedich-396	77	19	active	active	ADJ
biomedich-396	77	20	residues	residue	NOUN
biomedich-396	77	21	ile	ile	PROPN
biomedich-396	77	22	122	122	NUM
biomedich-396	77	23	,	,	PUNCT
biomedich-396	77	24	ile	ile	PROPN
biomedich-396	77	25	16	16	NUM
biomedich-396	77	26	,	,	PUNCT
biomedich-396	77	27	leu	leu	PROPN
biomedich-396	77	28	207	207	NUM
biomedich-396	77	29	,	,	PUNCT
biomedich-396	77	30	met	meet	VERB
biomedich-396	77	31	103	103	NUM
biomedich-396	77	32	,	,	PUNCT
biomedich-396	77	33	ile	ile	PROPN
biomedich-396	77	34	21	21	NUM
biomedich-396	77	35	,	,	PUNCT
biomedich-396	77	36	leu	leu	PROPN
biomedich-396	77	37	207	207	NUM
biomedich-396	77	38	and	and	CCONJ
biomedich-396	77	39	gly	gly	ADV
biomedich-396	77	40	14	14	NUM
biomedich-396	77	41	,	,	PUNCT
biomedich-396	77	42	ile	ile	PROPN
biomedich-396	77	43	122	122	NUM
biomedich-396	77	44	,	,	PUNCT
biomedich-396	77	45	phe	phe	NOUN
biomedich-396	77	46	97	97	NUM
biomedich-396	77	47	with	with	ADP
biomedich-396	77	48	substantially	substantially	ADV
biomedich-396	77	49	shorter	short	ADJ
biomedich-396	77	50	bond	bond	NOUN
biomedich-396	77	51	lengths	length	NOUN
biomedich-396	77	52	.	.	PUNCT
biomedich-396	78	1	figure	figure	NOUN
biomedich-396	78	2	4	4	NUM
biomedich-396	78	3	demonstrates	demonstrate	VERB
biomedich-396	78	4	the	the	DET
biomedich-396	78	5	interactions	interaction	NOUN
biomedich-396	78	6	of	of	ADP
biomedich-396	78	7	all	all	DET
biomedich-396	78	8	compounds	compound	NOUN
biomedich-396	78	9	with	with	ADP
biomedich-396	78	10	mycobacterial	mycobacterial	ADJ
biomedich-396	78	11	acp	acp	PROPN
biomedich-396	78	12	reductase	reductase	NOUN
biomedich-396	78	13	enzyme	enzyme	NOUN
biomedich-396	78	14	.	.	PUNCT
biomedich-396	79	1	admet	admet	PROPN
biomedich-396	79	2	analysis	analysis	NOUN
biomedich-396	79	3	absorption	absorption	NOUN
biomedich-396	79	4	,	,	PUNCT
biomedich-396	79	5	distribution	distribution	NOUN
biomedich-396	79	6	,	,	PUNCT
biomedich-396	79	7	metabolism	metabolism	NOUN
biomedich-396	79	8	,	,	PUNCT
biomedich-396	79	9	elimination	elimination	NOUN
biomedich-396	79	10	and	and	CCONJ
biomedich-396	79	11	toxicity	toxicity	NOUN
biomedich-396	79	12	(	(	PUNCT
biomedich-396	79	13	admet	admet	PROPN
biomedich-396	79	14	)	)	PUNCT
biomedich-396	79	15	analysis	analysis	NOUN
biomedich-396	79	16	is	be	AUX
biomedich-396	79	17	essential	essential	ADJ
biomedich-396	79	18	for	for	ADP
biomedich-396	79	19	navigating	navigate	VERB
biomedich-396	79	20	the	the	DET
biomedich-396	79	21	pharmacodynamics	pharmacodynamic	NOUN
biomedich-396	79	22	and	and	CCONJ
biomedich-396	79	23	pharmacokinetics	pharmacokinetic	NOUN
biomedich-396	79	24	of	of	ADP
biomedich-396	79	25	a	a	DET
biomedich-396	79	26	potential	potential	ADJ
biomedich-396	79	27	drug	drug	NOUN
biomedich-396	79	28	candidate	candidate	NOUN
biomedich-396	79	29	.	.	PUNCT
biomedich-396	80	1	in	in	ADP
biomedich-396	80	2	-	-	PUNCT
biomedich-396	80	3	silico	silico	NOUN
biomedich-396	80	4	adme	adme	NOUN
biomedich-396	80	5	parameters	parameter	NOUN
biomedich-396	80	6	were	be	AUX
biomedich-396	80	7	studied	study	VERB
biomedich-396	80	8	using	use	VERB
biomedich-396	80	9	swiss	swiss	ADJ
biomedich-396	80	10	adme	adme	NOUN
biomedich-396	80	11	.	.	PUNCT
biomedich-396	81	1	the	the	DET
biomedich-396	81	2	druglikeness	druglikeness	NOUN
biomedich-396	81	3	score	score	NOUN
biomedich-396	81	4	and	and	CCONJ
biomedich-396	81	5	toxicity	toxicity	NOUN
biomedich-396	81	6	profile	profile	NOUN
biomedich-396	81	7	of	of	ADP
biomedich-396	81	8	the	the	DET
biomedich-396	81	9	potential	potential	ADJ
biomedich-396	81	10	drug	drug	NOUN
biomedich-396	81	11	candidates	candidate	NOUN
biomedich-396	81	12	was	be	AUX
biomedich-396	81	13	probed	probe	VERB
biomedich-396	81	14	using	use	VERB
biomedich-396	81	15	datawarrior	datawarrior	ADJ
biomedich-396	81	16	v5.5.0	v5.5.0	NOUN
biomedich-396	81	17	.	.	PUNCT
biomedich-396	82	1	table	table	NOUN
biomedich-396	82	2	3	3	NUM
biomedich-396	82	3	shows	show	VERB
biomedich-396	82	4	the	the	DET
biomedich-396	82	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-396	82	6	and	and	CCONJ
biomedich-396	82	7	toxicity	toxicity	NOUN
biomedich-396	82	8	parameters	parameter	NOUN
biomedich-396	82	9	of	of	ADP
biomedich-396	82	10	the	the	DET
biomedich-396	82	11	potential	potential	ADJ
biomedich-396	82	12	drug	drug	NOUN
biomedich-396	82	13	candidates	candidate	NOUN
biomedich-396	82	14	from	from	ADP
biomedich-396	82	15	c1	c1	PROPN
biomedich-396	82	16	to	to	ADP
biomedich-396	82	17	c5	c5	PROPN
biomedich-396	82	18	.	.	PUNCT
biomedich-396	83	1	figure	figure	NOUN
biomedich-396	83	2	5	5	NUM
biomedich-396	83	3	manifests	manifest	NOUN
biomedich-396	83	4	the	the	DET
biomedich-396	83	5	bioavailability	bioavailability	NOUN
biomedich-396	83	6	radar	radar	NOUN
biomedich-396	83	7	of	of	ADP
biomedich-396	83	8	best	good	ADJ
biomedich-396	83	9	docked	docked	ADJ
biomedich-396	83	10	ligand	ligand	NOUN
biomedich-396	83	11	,	,	PUNCT
biomedich-396	83	12	compound	compound	NOUN
biomedich-396	83	13	c1	c1	PROPN
biomedich-396	83	14	,	,	PUNCT
biomedich-396	83	15	obtained	obtain	VERB
biomedich-396	83	16	from	from	ADP
biomedich-396	83	17	swissadme	swissadme	PROPN
biomedich-396	83	18	tool	tool	PROPN
biomedich-396	83	19	.	.	PUNCT
biomedich-396	84	1	figure	figure	VERB
biomedich-396	84	2	4	4	NUM
biomedich-396	84	3	.	.	PUNCT
biomedich-396	85	1	the	the	DET
biomedich-396	85	2	figure	figure	NOUN
biomedich-396	85	3	displays	display	VERB
biomedich-396	85	4	the	the	DET
biomedich-396	85	5	3d	3d	NOUN
biomedich-396	85	6	and	and	CCONJ
biomedich-396	85	7	2d	2d	NUM
biomedich-396	85	8	images	image	NOUN
biomedich-396	85	9	of	of	ADP
biomedich-396	85	10	the	the	DET
biomedich-396	85	11	interactions	interaction	NOUN
biomedich-396	85	12	between	between	ADP
biomedich-396	85	13	active	active	ADJ
biomedich-396	85	14	amino	amino	NOUN
biomedich-396	85	15	acid	acid	NOUN
biomedich-396	85	16	residues	residue	NOUN
biomedich-396	85	17	of	of	ADP
biomedich-396	85	18	mycobacterial	mycobacterial	ADJ
biomedich-396	85	19	acyl	acyl	NOUN
biomedich-396	85	20	carrier	carrier	NOUN
biomedich-396	85	21	protein	protein	NOUN
biomedich-396	85	22	reductase	reductase	NOUN
biomedich-396	85	23	(	(	PUNCT
biomedich-396	85	24	pdb	pdb	PROPN
biomedich-396	85	25	i	i	PROPN
biomedich-396	85	26	d	d	PROPN
biomedich-396	85	27	:	:	PUNCT
biomedich-396	85	28	4r9s	4r9s	NUM
biomedich-396	85	29	)	)	PUNCT
biomedich-396	85	30	and	and	CCONJ
biomedich-396	85	31	compounds	compound	NOUN
biomedich-396	85	32	(	(	PUNCT
biomedich-396	85	33	c1	c1	PROPN
biomedich-396	85	34	,	,	PUNCT
biomedich-396	85	35	c2	c2	PROPN
biomedich-396	85	36	,	,	PUNCT
biomedich-396	85	37	c3	c3	PROPN
biomedich-396	85	38	,	,	PUNCT
biomedich-396	85	39	c4	c4	NOUN
biomedich-396	85	40	and	and	CCONJ
biomedich-396	85	41	c5	c5	PROPN
biomedich-396	85	42	)	)	PUNCT
biomedich-396	85	43	.	.	PUNCT
biomedich-396	86	1	446	446	NUM
biomedich-396	86	2	biology	biology	NOUN
biomedich-396	86	3	,	,	PUNCT
biomedich-396	86	4	medicine	medicine	NOUN
biomedich-396	86	5	,	,	PUNCT
biomedich-396	86	6	&	&	CCONJ
biomedich-396	86	7	natural	natural	ADJ
biomedich-396	86	8	product	product	NOUN
biomedich-396	86	9	chemistry	chemistry	NOUN
biomedich-396	86	10	12	12	NUM
biomedich-396	86	11	(	(	PUNCT
biomedich-396	86	12	2	2	NUM
biomedich-396	86	13	)	)	PUNCT
biomedich-396	86	14	,	,	PUNCT
biomedich-396	86	15	2023	2023	NUM
biomedich-396	86	16	:	:	PUNCT
biomedich-396	86	17	441	441	NUM
biomedich-396	86	18	-	-	SYM
biomedich-396	86	19	450	450	NUM
biomedich-396	86	20	table	table	NOUN
biomedich-396	86	21	3	3	NUM
biomedich-396	86	22	.	.	PUNCT
biomedich-396	87	1	the	the	DET
biomedich-396	87	2	table	table	NOUN
biomedich-396	87	3	provides	provide	VERB
biomedich-396	87	4	the	the	DET
biomedich-396	87	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-396	87	6	and	and	CCONJ
biomedich-396	87	7	toxicity	toxicity	NOUN
biomedich-396	87	8	profile	profile	NOUN
biomedich-396	87	9	of	of	ADP
biomedich-396	87	10	compounds	compound	NOUN
biomedich-396	87	11	(	(	PUNCT
biomedich-396	87	12	c1	c1	PROPN
biomedich-396	87	13	–	–	PUNCT
biomedich-396	87	14	c5	c5	PROPN
biomedich-396	87	15	)	)	PUNCT
biomedich-396	87	16	using	use	VERB
biomedich-396	87	17	swissadme	swissadme	NOUN
biomedich-396	87	18	and	and	CCONJ
biomedich-396	87	19	datawarrior	datawarrior	ADJ
biomedich-396	87	20	tools	tool	NOUN
biomedich-396	87	21	.	.	PUNCT
biomedich-396	88	1	admet	admet	PROPN
biomedich-396	88	2	profiling	profiling	NOUN
biomedich-396	88	3	of	of	ADP
biomedich-396	88	4	the	the	DET
biomedich-396	88	5	potential	potential	ADJ
biomedich-396	88	6	drug	drug	NOUN
biomedich-396	88	7	candidates	candidate	NOUN
biomedich-396	88	8	(	(	PUNCT
biomedich-396	88	9	c1	c1	PROPN
biomedich-396	88	10	–	–	PUNCT
biomedich-396	88	11	c5	c5	PROPN
biomedich-396	88	12	)	)	PUNCT
biomedich-396	88	13	potential	potential	ADJ
biomedich-396	88	14	drug	drug	NOUN
biomedich-396	88	15	candidates	candidate	NOUN
biomedich-396	88	16	c1	c1	PROPN
biomedich-396	88	17	c2	c2	PROPN
biomedich-396	88	18	c3	c3	PROPN
biomedich-396	88	19	c4	c4	PROPN
biomedich-396	88	20	c5	c5	PROPN
biomedich-396	88	21	physicochemical	physicochemical	ADJ
biomedich-396	88	22	properties	property	NOUN
biomedich-396	88	23	molecular	molecular	ADJ
biomedich-396	88	24	weight	weight	NOUN
biomedich-396	88	25	(	(	PUNCT
biomedich-396	88	26	g	g	NOUN
biomedich-396	88	27	/	/	SYM
biomedich-396	88	28	mol	mol	NOUN
biomedich-396	88	29	)	)	PUNCT
biomedich-396	88	30	353.37	353.37	NUM
biomedich-396	88	31	g	g	NOUN
biomedich-396	88	32	/	/	SYM
biomedich-396	88	33	mol	mol	ADP
biomedich-396	88	34	235.32	235.32	NUM
biomedich-396	88	35	g	g	NOUN
biomedich-396	88	36	/	/	SYM
biomedich-396	88	37	mol	mol	ADP
biomedich-396	88	38	332.33	332.33	NUM
biomedich-396	88	39	g	g	NOUN
biomedich-396	88	40	/	/	SYM
biomedich-396	88	41	mol	mol	ADP
biomedich-396	88	42	608.72	608.72	NUM
biomedich-396	88	43	g	g	NOUN
biomedich-396	88	44	/	/	SYM
biomedich-396	88	45	mol	mol	ADP
biomedich-396	88	46	348.37	348.37	NUM
biomedich-396	88	47	g	g	NOUN
biomedich-396	88	48	/	/	SYM
biomedich-396	88	49	mol	mol	NOUN
biomedich-396	88	50	log	log	NOUN
biomedich-396	88	51	p	p	PROPN
biomedich-396	88	52	2.67	2.67	NUM
biomedich-396	88	53	3.23	3.23	NUM
biomedich-396	88	54	2.84	2.84	NUM
biomedich-396	88	55	5.17	5.17	NUM
biomedich-396	88	56	3.02	3.02	NUM
biomedich-396	88	57	h	h	NOUN
biomedich-396	88	58	-	-	PUNCT
biomedich-396	88	59	acceptor	acceptor	NOUN
biomedich-396	88	60	6	6	NUM
biomedich-396	88	61	1	1	NUM
biomedich-396	88	62	4	4	NUM
biomedich-396	88	63	8	8	NUM
biomedich-396	88	64	4	4	NUM
biomedich-396	88	65	h	h	NOUN
biomedich-396	88	66	-	-	PUNCT
biomedich-396	88	67	donor	donor	NOUN
biomedich-396	88	68	0	0	NUM
biomedich-396	88	69	0	0	NUM
biomedich-396	88	70	0	0	NUM
biomedich-396	88	71	1	1	NUM
biomedich-396	88	72	0	0	NUM
biomedich-396	88	73	n.r.b	n.r.b	ADJ
biomedich-396	88	74	0	0	NUM
biomedich-396	88	75	0	0	NUM
biomedich-396	88	76	0	0	NUM
biomedich-396	88	77	3	3	NUM
biomedich-396	88	78	2	2	NUM
biomedich-396	88	79	tpsa	tpsa	NOUN
biomedich-396	88	80	(	(	PUNCT
biomedich-396	88	81	å²	å²	PROPN
biomedich-396	88	82	)	)	PUNCT
biomedich-396	88	83	57.23	57.23	NUM
biomedich-396	88	84	å²	å²	PROPN
biomedich-396	88	85	3.24	3.24	NUM
biomedich-396	88	86	å²	å²	PROPN
biomedich-396	88	87	40.80	40.80	NUM
biomedich-396	88	88	å²	å²	PROPN
biomedich-396	88	89	72.86	72.86	NUM
biomedich-396	88	90	å²	å²	PROPN
biomedich-396	88	91	40.80	40.80	NUM
biomedich-396	88	92	å²	å²	PROPN
biomedich-396	88	93	bioavailability	bioavailability	NOUN
biomedich-396	88	94	score	score	NOUN
biomedich-396	88	95	0.55	0.55	NUM
biomedich-396	88	96	0.55	0.55	NUM
biomedich-396	88	97	0.55	0.55	NUM
biomedich-396	88	98	0.55	0.55	NUM
biomedich-396	88	99	0.55	0.55	NUM
biomedich-396	88	100	drug	drug	NOUN
biomedich-396	88	101	-	-	PUNCT
biomedich-396	88	102	likeness	likeness	NOUN
biomedich-396	88	103	parameters	parameter	NOUN
biomedich-396	88	104	lipinski	lipinski	PROPN
biomedich-396	88	105	’s	’s	PART
biomedich-396	88	106	rule	rule	NOUN
biomedich-396	88	107	violations	violation	NOUN
biomedich-396	88	108	0	0	NUM
biomedich-396	88	109	violations	violation	NOUN
biomedich-396	88	110	0	0	NUM
biomedich-396	88	111	violations	violation	NOUN
biomedich-396	88	112	0	0	NUM
biomedich-396	88	113	violations	violation	NOUN
biomedich-396	88	114	1	1	NUM
biomedich-396	88	115	violation	violation	NOUN
biomedich-396	88	116	0	0	NUM
biomedich-396	88	117	violation	violation	NOUN
biomedich-396	88	118	drug	drug	NOUN
biomedich-396	88	119	-	-	PUNCT
biomedich-396	88	120	likeness	likeness	NOUN
biomedich-396	88	121	score	score	NOUN
biomedich-396	88	122	4.7237	4.7237	NUM
biomedich-396	88	123	4.9313	4.9313	NUM
biomedich-396	88	124	2.4707	2.4707	NUM
biomedich-396	88	125	4.6261	4.6261	NUM
biomedich-396	88	126	2.1842	2.1842	NUM
biomedich-396	88	127	metabolic	metabolic	NOUN
biomedich-396	88	128	profiling	profile	VERB
biomedich-396	88	129	p	p	ADJ
biomedich-396	88	130	-	-	PUNCT
biomedich-396	88	131	glycoprotein	glycoprotein	NOUN
biomedich-396	88	132	substrate	substrate	NOUN
biomedich-396	89	1	yes	yes	INTJ
biomedich-396	89	2	yes	yes	INTJ
biomedich-396	90	1	yes	yes	INTJ
biomedich-396	91	1	no	no	INTJ
biomedich-396	92	1	yes	yes	INTJ
biomedich-396	92	2	gi	gi	INTJ
biomedich-396	92	3	absorption	absorption	NOUN
biomedich-396	92	4	high	high	ADJ
biomedich-396	92	5	high	high	ADJ
biomedich-396	92	6	high	high	ADJ
biomedich-396	92	7	high	high	ADJ
biomedich-396	92	8	high	high	ADJ
biomedich-396	92	9	cyp	cyp	ADJ
biomedich-396	92	10	3a4	3a4	NUM
biomedich-396	93	1	yes	yes	INTJ
biomedich-396	94	1	no	no	INTJ
biomedich-396	94	2	no	no	INTJ
biomedich-396	95	1	no	no	INTJ
biomedich-396	95	2	yes	yes	INTJ
biomedich-396	95	3	cyp	cyp	ADJ
biomedich-396	95	4	2d6	2d6	NUM
biomedich-396	96	1	yes	yes	INTJ
biomedich-396	97	1	yes	yes	INTJ
biomedich-396	97	2	no	no	INTJ
biomedich-396	98	1	no	no	INTJ
biomedich-396	98	2	no	no	INTJ
biomedich-396	98	3	cyp	cyp	ADJ
biomedich-396	99	1	1a2	1a2	INTJ
biomedich-396	100	1	yes	yes	INTJ
biomedich-396	101	1	no	no	INTJ
biomedich-396	102	1	yes	yes	INTJ
biomedich-396	103	1	no	no	INTJ
biomedich-396	103	2	yes	yes	INTJ
biomedich-396	103	3	cyp	cyp	ADJ
biomedich-396	103	4	2c9	2c9	NUM
biomedich-396	104	1	yes	yes	INTJ
biomedich-396	105	1	no	no	INTJ
biomedich-396	105	2	no	no	INTJ
biomedich-396	106	1	no	no	INTJ
biomedich-396	106	2	yes	yes	INTJ
biomedich-396	106	3	cyp	cyp	ADJ
biomedich-396	106	4	2c19	2c19	NOUN
biomedich-396	107	1	no	no	INTJ
biomedich-396	108	1	no	no	INTJ
biomedich-396	108	2	yes	yes	INTJ
biomedich-396	109	1	no	no	INTJ
biomedich-396	109	2	yes	yes	INTJ
biomedich-396	110	1	toxicity	toxicity	NOUN
biomedich-396	110	2	profiling	profiling	NOUN
biomedich-396	110	3	tumorgenicity	tumorgenicity	NOUN
biomedich-396	111	1	no	no	INTJ
biomedich-396	111	2	no	no	INTJ
biomedich-396	111	3	no	no	INTJ
biomedich-396	111	4	no	no	INTJ
biomedich-396	111	5	no	no	DET
biomedich-396	111	6	mutagenesis	mutagenesis	NOUN
biomedich-396	111	7	no	no	INTJ
biomedich-396	112	1	no	no	INTJ
biomedich-396	112	2	no	no	INTJ
biomedich-396	112	3	no	no	INTJ
biomedich-396	112	4	no	no	INTJ
biomedich-396	112	5	irritant	irritant	ADJ
biomedich-396	112	6	no	no	INTJ
biomedich-396	113	1	no	no	INTJ
biomedich-396	113	2	no	no	INTJ
biomedich-396	113	3	no	no	INTJ
biomedich-396	113	4	no	no	DET
biomedich-396	113	5	reproductive	reproductive	ADJ
biomedich-396	113	6	effects	effect	NOUN
biomedich-396	113	7	no	no	INTJ
biomedich-396	113	8	no	no	INTJ
biomedich-396	113	9	no	no	INTJ
biomedich-396	113	10	no	no	INTJ
biomedich-396	113	11	no	no	DET
biomedich-396	113	12	mol	mol	NOUN
biomedich-396	113	13	.	.	PUNCT
biomedich-396	114	1	w	w	PROPN
biomedich-396	114	2	(	(	PUNCT
biomedich-396	114	3	g	g	NOUN
biomedich-396	114	4	/	/	SYM
biomedich-396	114	5	mol	mol	NOUN
biomedich-396	114	6	)	)	PUNCT
biomedich-396	114	7	molecular	molecular	ADJ
biomedich-396	114	8	weight	weight	NOUN
biomedich-396	114	9	,	,	PUNCT
biomedich-396	114	10	log	log	VERB
biomedich-396	114	11	p	p	NOUN
biomedich-396	114	12	prediction	prediction	NOUN
biomedich-396	114	13	of	of	ADP
biomedich-396	114	14	octanol	octanol	NOUN
biomedich-396	114	15	/	/	SYM
biomedich-396	114	16	water	water	NOUN
biomedich-396	114	17	partition	partition	NOUN
biomedich-396	114	18	coefficient	coefficient	NOUN
biomedich-396	114	19	,	,	PUNCT
biomedich-396	114	20	n.r.b	n.r.b	ADJ
biomedich-396	114	21	number	number	NOUN
biomedich-396	114	22	of	of	ADP
biomedich-396	114	23	rotable	rotable	ADJ
biomedich-396	114	24	bonds	bond	NOUN
biomedich-396	114	25	,	,	PUNCT
biomedich-396	114	26	tpsa	tpsa	NOUN
biomedich-396	114	27	(	(	PUNCT
biomedich-396	114	28	å²	å²	PROPN
biomedich-396	114	29	)	)	PUNCT
biomedich-396	114	30	topological	topological	ADJ
biomedich-396	114	31	polar	polar	ADJ
biomedich-396	114	32	surface	surface	NOUN
biomedich-396	114	33	area	area	NOUN
biomedich-396	114	34	,	,	PUNCT
biomedich-396	114	35	cyp	cyp	ADJ
biomedich-396	114	36	cytochrome	cytochrome	NOUN
biomedich-396	114	37	p-450	p-450	NOUN
biomedich-396	114	38	enzyme	enzyme	NOUN
biomedich-396	114	39	.	.	PUNCT
biomedich-396	115	1	figure	figure	NOUN
biomedich-396	115	2	5	5	NUM
biomedich-396	115	3	.	.	PUNCT
biomedich-396	116	1	the	the	DET
biomedich-396	116	2	figure	figure	NOUN
biomedich-396	116	3	the	the	DET
biomedich-396	116	4	bioavailability	bioavailability	NOUN
biomedich-396	116	5	radar	radar	NOUN
biomedich-396	116	6	of	of	ADP
biomedich-396	116	7	ligand	ligand	ADJ
biomedich-396	116	8	c1	c1	PROPN
biomedich-396	116	9	(	(	PUNCT
biomedich-396	116	10	having	have	VERB
biomedich-396	116	11	the	the	DET
biomedich-396	116	12	most	most	ADV
biomedich-396	116	13	favorable	favorable	ADJ
biomedich-396	116	14	binding	bind	VERB
biomedich-396	116	15	energies	energy	NOUN
biomedich-396	116	16	as	as	ADP
biomedich-396	116	17	per	per	ADP
biomedich-396	116	18	the	the	DET
biomedich-396	116	19	findings	finding	NOUN
biomedich-396	116	20	of	of	ADP
biomedich-396	116	21	molecular	molecular	ADJ
biomedich-396	116	22	docking	docking	NOUN
biomedich-396	116	23	)	)	PUNCT
biomedich-396	116	24	.	.	PUNCT
biomedich-396	117	1	molecular	molecular	ADJ
biomedich-396	117	2	dynamic	dynamic	ADJ
biomedich-396	117	3	simulation	simulation	NOUN
biomedich-396	117	4	molecular	molecular	ADJ
biomedich-396	117	5	dynamic	dynamic	ADJ
biomedich-396	117	6	(	(	PUNCT
biomedich-396	117	7	md	md	PROPN
biomedich-396	117	8	)	)	PUNCT
biomedich-396	117	9	simulations	simulation	NOUN
biomedich-396	117	10	depict	depict	VERB
biomedich-396	117	11	the	the	DET
biomedich-396	117	12	dynamics	dynamic	NOUN
biomedich-396	117	13	of	of	ADP
biomedich-396	117	14	a	a	DET
biomedich-396	117	15	macromolecule	macromolecule	NOUN
biomedich-396	117	16	bound	bind	VERB
biomedich-396	117	17	by	by	ADP
biomedich-396	117	18	a	a	DET
biomedich-396	117	19	ligand	ligand	NOUN
biomedich-396	117	20	,	,	PUNCT
biomedich-396	117	21	interactions	interaction	NOUN
biomedich-396	117	22	between	between	ADP
biomedich-396	117	23	the	the	DET
biomedich-396	117	24	amino	amino	NOUN
biomedich-396	117	25	acid	acid	NOUN
biomedich-396	117	26	residues	residue	NOUN
biomedich-396	117	27	and	and	CCONJ
biomedich-396	117	28	navigating	navigate	VERB
biomedich-396	117	29	the	the	DET
biomedich-396	117	30	configurations	configuration	NOUN
biomedich-396	117	31	of	of	ADP
biomedich-396	117	32	a	a	DET
biomedich-396	117	33	protein	protein	NOUN
biomedich-396	117	34	molecule	molecule	NOUN
biomedich-396	117	35	(	(	PUNCT
biomedich-396	117	36	y.	y.	PROPN
biomedich-396	117	37	wang	wang	PROPN
biomedich-396	117	38	,	,	PUNCT
biomedich-396	117	39	ribeiro	ribeiro	PROPN
biomedich-396	117	40	,	,	PUNCT
biomedich-396	117	41	&	&	CCONJ
biomedich-396	117	42	tiwary	tiwary	PROPN
biomedich-396	117	43	,	,	PUNCT
biomedich-396	117	44	2020	2020	NUM
biomedich-396	117	45	)	)	PUNCT
biomedich-396	117	46	.	.	PUNCT
biomedich-396	118	1	md	md	PROPN
biomedich-396	118	2	simulations	simulation	NOUN
biomedich-396	118	3	unveil	unveil	VERB
biomedich-396	118	4	the	the	DET
biomedich-396	118	5	dynamics	dynamic	NOUN
biomedich-396	118	6	of	of	ADP
biomedich-396	118	7	a	a	DET
biomedich-396	118	8	protein	protein	NOUN
biomedich-396	118	9	and	and	CCONJ
biomedich-396	118	10	assist	assist	VERB
biomedich-396	118	11	in	in	ADP
biomedich-396	118	12	discovering	discover	VERB
biomedich-396	118	13	the	the	DET
biomedich-396	118	14	cryptic	cryptic	ADJ
biomedich-396	118	15	sites	site	NOUN
biomedich-396	118	16	in	in	ADP
biomedich-396	118	17	a	a	DET
biomedich-396	118	18	protein	protein	NOUN
biomedich-396	118	19	macromolecule	macromolecule	NOUN
biomedich-396	118	20	that	that	PRON
biomedich-396	118	21	may	may	AUX
biomedich-396	118	22	have	have	VERB
biomedich-396	118	23	affinity	affinity	NOUN
biomedich-396	118	24	towards	towards	ADP
biomedich-396	118	25	a	a	DET
biomedich-396	118	26	ligand	ligand	NOUN
biomedich-396	118	27	,	,	PUNCT
biomedich-396	118	28	thereby	thereby	ADV
biomedich-396	118	29	facilitating	facilitate	VERB
biomedich-396	118	30	its	its	PRON
biomedich-396	118	31	binding	binding	NOUN
biomedich-396	118	32	to	to	ADP
biomedich-396	118	33	the	the	DET
biomedich-396	118	34	hydrophobic	hydrophobic	NOUN
biomedich-396	118	35	pocket	pocket	NOUN
biomedich-396	118	36	(	(	PUNCT
biomedich-396	118	37	kuzmanic	kuzmanic	ADJ
biomedich-396	118	38	,	,	PUNCT
biomedich-396	118	39	bowman	bowman	PROPN
biomedich-396	118	40	,	,	PUNCT
biomedich-396	118	41	juarezjimenez	juarezjimenez	PROPN
biomedich-396	118	42	,	,	PUNCT
biomedich-396	118	43	michel	michel	PROPN
biomedich-396	118	44	,	,	PUNCT
biomedich-396	118	45	&	&	CCONJ
biomedich-396	118	46	gervasio	gervasio	ADJ
biomedich-396	118	47	,	,	PUNCT
biomedich-396	118	48	2020	2020	NUM
biomedich-396	118	49	)	)	PUNCT
biomedich-396	118	50	.	.	PUNCT
biomedich-396	119	1	md	md	PROPN
biomedich-396	119	2	simulations	simulation	NOUN
biomedich-396	119	3	were	be	AUX
biomedich-396	119	4	done	do	VERB
biomedich-396	119	5	using	use	VERB
biomedich-396	119	6	the	the	DET
biomedich-396	119	7	online	online	PROPN
biomedich-396	119	8	md	md	PROPN
biomedich-396	119	9	simulation	simulation	PROPN
biomedich-396	119	10	tool	tool	PROPN
biomedich-396	119	11	,	,	PUNCT
biomedich-396	119	12	imods	imod	NOUN
biomedich-396	119	13	server	server	PROPN
biomedich-396	119	14	(	(	PUNCT
biomedich-396	119	15	lópez	lópez	NOUN
biomedich-396	119	16	-	-	PUNCT
biomedich-396	119	17	blanco	blanco	PROPN
biomedich-396	119	18	,	,	PUNCT
biomedich-396	119	19	aliaga	aliaga	PROPN
biomedich-396	119	20	,	,	PUNCT
biomedich-396	119	21	quintana	quintana	NOUN
biomedich-396	119	22	-	-	PUNCT
biomedich-396	119	23	ortí	ortí	NOUN
biomedich-396	119	24	,	,	PUNCT
biomedich-396	119	25	&	&	CCONJ
biomedich-396	119	26	chacón	chacón	PROPN
biomedich-396	119	27	,	,	PUNCT
biomedich-396	119	28	2014	2014	NUM
biomedich-396	119	29	;	;	PUNCT
biomedich-396	119	30	lopéz	lopéz	NOUN
biomedich-396	119	31	-	-	PUNCT
biomedich-396	119	32	blanco	blanco	PROPN
biomedich-396	119	33	,	,	PUNCT
biomedich-396	119	34	garzón	garzón	PROPN
biomedich-396	119	35	,	,	PUNCT
biomedich-396	119	36	&	&	CCONJ
biomedich-396	119	37	chacón	chacón	PROPN
biomedich-396	119	38	,	,	PUNCT
biomedich-396	119	39	2011	2011	NUM
biomedich-396	119	40	)	)	PUNCT
biomedich-396	119	41	.	.	PUNCT
biomedich-396	120	1	the	the	DET
biomedich-396	120	2	ligand	ligand	ADJ
biomedich-396	120	3	and	and	CCONJ
biomedich-396	120	4	macromolecule	macromolecule	NOUN
biomedich-396	120	5	docked	docked	ADJ
biomedich-396	120	6	complex	complex	ADJ
biomedich-396	120	7	c1	c1	NOUN
biomedich-396	120	8	(	(	PUNCT
biomedich-396	120	9	protopine	protopine	NOUN
biomedich-396	120	10	)	)	PUNCT
biomedich-396	120	11	was	be	AUX
biomedich-396	120	12	loaded	load	VERB
biomedich-396	120	13	on	on	ADP
biomedich-396	120	14	imods	imod	NOUN
biomedich-396	120	15	server	server	NOUN
biomedich-396	120	16	and	and	CCONJ
biomedich-396	120	17	md	md	PROPN
biomedich-396	120	18	simulation	simulation	NOUN
biomedich-396	120	19	was	be	AUX
biomedich-396	120	20	performed	perform	VERB
biomedich-396	120	21	on	on	ADP
biomedich-396	120	22	normal	normal	ADJ
biomedich-396	120	23	mode	mode	NOUN
biomedich-396	120	24	analysis	analysis	NOUN
biomedich-396	120	25	(	(	PUNCT
biomedich-396	120	26	nma	nma	PROPN
biomedich-396	120	27	)	)	PUNCT
biomedich-396	120	28	.	.	PUNCT
biomedich-396	121	1	the	the	DET
biomedich-396	121	2	b	b	NOUN
biomedich-396	121	3	-	-	PUNCT
biomedich-396	121	4	factor	factor	NOUN
biomedich-396	121	5	yielded	yield	VERB
biomedich-396	121	6	information	information	NOUN
biomedich-396	121	7	regarding	regard	VERB
biomedich-396	121	8	the	the	DET
biomedich-396	121	9	flexible	flexible	ADJ
biomedich-396	121	10	nature	nature	NOUN
biomedich-396	121	11	of	of	ADP
biomedich-396	121	12	the	the	DET
biomedich-396	121	13	macromolecule	macromolecule	NOUN
biomedich-396	121	14	.	.	PUNCT
biomedich-396	122	1	it	it	PRON
biomedich-396	122	2	illustrates	illustrate	VERB
biomedich-396	122	3	the	the	DET
biomedich-396	122	4	deforming	deform	VERB
biomedich-396	122	5	tendency	tendency	NOUN
biomedich-396	122	6	of	of	ADP
biomedich-396	122	7	the	the	DET
biomedich-396	122	8	protein	protein	NOUN
biomedich-396	122	9	residues	residue	NOUN
biomedich-396	122	10	in	in	ADP
biomedich-396	122	11	order	order	NOUN
biomedich-396	122	12	to	to	PART
biomedich-396	122	13	interact	interact	VERB
biomedich-396	122	14	with	with	ADP
biomedich-396	122	15	protopine	protopine	NOUN
biomedich-396	122	16	molecule	molecule	NOUN
biomedich-396	122	17	.	.	PUNCT
biomedich-396	123	1	the	the	DET
biomedich-396	123	2	arrow	arrow	NOUN
biomedich-396	123	3	field	field	NOUN
biomedich-396	123	4	shows	show	VERB
biomedich-396	123	5	the	the	DET
biomedich-396	123	6	orientation	orientation	NOUN
biomedich-396	123	7	of	of	ADP
biomedich-396	123	8	the	the	DET
biomedich-396	123	9	macromolecule	macromolecule	NOUN
biomedich-396	123	10	in	in	ADP
biomedich-396	123	11	the	the	DET
biomedich-396	123	12	virtual	virtual	ADJ
biomedich-396	123	13	experiment	experiment	NOUN
biomedich-396	123	14	.	.	PUNCT
biomedich-396	124	1	the	the	DET
biomedich-396	124	2	figures	figure	NOUN
biomedich-396	124	3	6,7	6,7	NUM
biomedich-396	124	4	and	and	CCONJ
biomedich-396	124	5	8	8	NUM
biomedich-396	124	6	provide	provide	VERB
biomedich-396	124	7	the	the	DET
biomedich-396	124	8	graphical	graphical	ADJ
biomedich-396	124	9	presentation	presentation	NOUN
biomedich-396	124	10	of	of	ADP
biomedich-396	124	11	the	the	DET
biomedich-396	124	12	finding	finding	NOUN
biomedich-396	124	13	of	of	ADP
biomedich-396	124	14	molecular	molecular	ADJ
biomedich-396	124	15	dynamic	dynamic	ADJ
biomedich-396	124	16	simulation	simulation	NOUN
biomedich-396	124	17	analysis	analysis	NOUN
biomedich-396	124	18	.	.	PUNCT
biomedich-396	125	1	kamran	kamran	PROPN
biomedich-396	125	2	&	&	CCONJ
biomedich-396	125	3	ibrahim	ibrahim	PROPN
biomedich-396	125	4	–	–	PUNCT
biomedich-396	125	5	alkaloids	alkaloid	NOUN
biomedich-396	125	6	lead	lead	VERB
biomedich-396	125	7	to	to	ADP
biomedich-396	125	8	potential	potential	ADJ
biomedich-396	125	9	inhibition	inhibition	NOUN
biomedich-396	125	10	of	of	ADP
biomedich-396	125	11	the	the	DET
biomedich-396	125	12	…	…	PUNCT
biomedich-396	125	13	447	447	NUM
biomedich-396	125	14	figure	figure	NOUN
biomedich-396	125	15	6	6	NUM
biomedich-396	125	16	.	.	PUNCT
biomedich-396	126	1	the	the	DET
biomedich-396	126	2	figure	figure	NOUN
biomedich-396	126	3	illustrates	illustrate	VERB
biomedich-396	126	4	the	the	DET
biomedich-396	126	5	orientation	orientation	NOUN
biomedich-396	126	6	of	of	ADP
biomedich-396	126	7	the	the	DET
biomedich-396	126	8	docked	docked	ADJ
biomedich-396	126	9	complex	complex	NOUN
biomedich-396	126	10	(	(	PUNCT
biomedich-396	126	11	c1	c1	NOUN
biomedich-396	126	12	and	and	CCONJ
biomedich-396	126	13	macromolecule	macromolecule	NOUN
biomedich-396	126	14	)	)	PUNCT
biomedich-396	126	15	obtained	obtain	VERB
biomedich-396	126	16	through	through	ADP
biomedich-396	126	17	molecular	molecular	ADJ
biomedich-396	126	18	dynamic	dynamic	ADJ
biomedich-396	126	19	simulations	simulation	NOUN
biomedich-396	126	20	using	use	VERB
biomedich-396	126	21	imods	imod	NOUN
biomedich-396	126	22	.	.	PUNCT
biomedich-396	127	1	the	the	DET
biomedich-396	127	2	eigenvalue	eigenvalue	NOUN
biomedich-396	127	3	for	for	ADP
biomedich-396	127	4	the	the	DET
biomedich-396	127	5	complex	complex	NOUN
biomedich-396	127	6	in	in	ADP
biomedich-396	127	7	this	this	DET
biomedich-396	127	8	virtual	virtual	ADJ
biomedich-396	127	9	experiment	experiment	NOUN
biomedich-396	127	10	was	be	AUX
biomedich-396	127	11	measured	measure	VERB
biomedich-396	127	12	as	as	ADP
biomedich-396	127	13	5.340225e-04	5.340225e-04	NUM
biomedich-396	127	14	.	.	PUNCT
biomedich-396	128	1	the	the	DET
biomedich-396	128	2	eigenvalue	eigenvalue	PROPN
biomedich-396	128	3	manifests	manifest	NOUN
biomedich-396	128	4	the	the	DET
biomedich-396	128	5	energy	energy	NOUN
biomedich-396	128	6	required	require	VERB
biomedich-396	128	7	to	to	PART
biomedich-396	128	8	deform	deform	VERB
biomedich-396	128	9	a	a	DET
biomedich-396	128	10	particular	particular	ADJ
biomedich-396	128	11	amino	amino	NOUN
biomedich-396	128	12	acid	acid	NOUN
biomedich-396	128	13	residue	residue	NOUN
biomedich-396	128	14	while	while	SCONJ
biomedich-396	128	15	interacting	interact	VERB
biomedich-396	128	16	with	with	ADP
biomedich-396	128	17	other	other	ADJ
biomedich-396	128	18	residues	residue	NOUN
biomedich-396	128	19	in	in	ADP
biomedich-396	128	20	a	a	DET
biomedich-396	128	21	reallife	reallife	NOUN
biomedich-396	128	22	environment	environment	NOUN
biomedich-396	128	23	created	create	VERB
biomedich-396	128	24	virtually	virtually	ADV
biomedich-396	128	25	.	.	PUNCT
biomedich-396	129	1	variance	variance	NOUN
biomedich-396	129	2	is	be	AUX
biomedich-396	129	3	inversely	inversely	ADV
biomedich-396	129	4	proportional	proportional	ADJ
biomedich-396	129	5	to	to	PART
biomedich-396	129	6	eigenvalue	eigenvalue	VERB
biomedich-396	129	7	and	and	CCONJ
biomedich-396	129	8	the	the	DET
biomedich-396	129	9	comparison	comparison	NOUN
biomedich-396	129	10	between	between	ADP
biomedich-396	129	11	the	the	DET
biomedich-396	129	12	two	two	NUM
biomedich-396	129	13	is	be	AUX
biomedich-396	129	14	shown	show	VERB
biomedich-396	129	15	in	in	ADP
biomedich-396	129	16	the	the	DET
biomedich-396	129	17	figure	figure	NOUN
biomedich-396	129	18	.	.	PUNCT
biomedich-396	130	1	figure	figure	VERB
biomedich-396	130	2	7	7	NUM
biomedich-396	130	3	.	.	PUNCT
biomedich-396	131	1	the	the	DET
biomedich-396	131	2	figure	figure	NOUN
biomedich-396	131	3	shows	show	VERB
biomedich-396	131	4	the	the	DET
biomedich-396	131	5	findings	finding	NOUN
biomedich-396	131	6	of	of	ADP
biomedich-396	131	7	molecular	molecular	ADJ
biomedich-396	131	8	dynamic	dynamic	ADJ
biomedich-396	131	9	simulation	simulation	NOUN
biomedich-396	131	10	i.e.	i.e.	X
biomedich-396	131	11	image	image	NOUN
biomedich-396	131	12	(	(	PUNCT
biomedich-396	131	13	a	a	X
biomedich-396	131	14	)	)	PUNCT
biomedich-396	131	15	shows	show	VERB
biomedich-396	131	16	the	the	DET
biomedich-396	131	17	deformability	deformability	NOUN
biomedich-396	131	18	of	of	ADP
biomedich-396	131	19	the	the	DET
biomedich-396	131	20	docked	docked	ADJ
biomedich-396	131	21	complex	complex	NOUN
biomedich-396	131	22	.	.	PUNCT
biomedich-396	132	1	image	image	NOUN
biomedich-396	132	2	(	(	PUNCT
biomedich-396	132	3	b	b	NOUN
biomedich-396	132	4	)	)	PUNCT
biomedich-396	132	5	provides	provide	VERB
biomedich-396	132	6	the	the	DET
biomedich-396	132	7	graphical	graphical	ADJ
biomedich-396	132	8	view	view	NOUN
biomedich-396	132	9	of	of	ADP
biomedich-396	132	10	the	the	DET
biomedich-396	132	11	bfactor	bfactor	NOUN
biomedich-396	132	12	.	.	PUNCT
biomedich-396	133	1	image	image	NOUN
biomedich-396	133	2	(	(	PUNCT
biomedich-396	133	3	c	c	NOUN
biomedich-396	133	4	)	)	PUNCT
biomedich-396	133	5	provides	provide	VERB
biomedich-396	133	6	the	the	DET
biomedich-396	133	7	eigenvalue	eigenvalue	NOUN
biomedich-396	133	8	for	for	ADP
biomedich-396	133	9	the	the	DET
biomedich-396	133	10	complex	complex	NOUN
biomedich-396	133	11	while	while	SCONJ
biomedich-396	133	12	the	the	DET
biomedich-396	133	13	image	image	NOUN
biomedich-396	133	14	(	(	PUNCT
biomedich-396	133	15	d	d	X
biomedich-396	133	16	)	)	PUNCT
biomedich-396	133	17	demonstrates	demonstrate	VERB
biomedich-396	133	18	the	the	DET
biomedich-396	133	19	percentage	percentage	NOUN
biomedich-396	133	20	variance	variance	NOUN
biomedich-396	133	21	.	.	PUNCT
biomedich-396	134	1	the	the	DET
biomedich-396	134	2	covariance	covariance	NOUN
biomedich-396	134	3	map	map	NOUN
biomedich-396	134	4	displays	display	VERB
biomedich-396	134	5	the	the	DET
biomedich-396	134	6	interactions	interaction	NOUN
biomedich-396	134	7	between	between	ADP
biomedich-396	134	8	the	the	DET
biomedich-396	134	9	residues	residue	NOUN
biomedich-396	134	10	of	of	ADP
biomedich-396	134	11	the	the	DET
biomedich-396	134	12	dynamic	dynamic	ADJ
biomedich-396	134	13	protein	protein	NOUN
biomedich-396	134	14	molecule	molecule	NOUN
biomedich-396	134	15	,	,	PUNCT
biomedich-396	134	16	with	with	ADP
biomedich-396	134	17	red	red	ADJ
biomedich-396	134	18	areas	area	NOUN
biomedich-396	134	19	showing	show	VERB
biomedich-396	134	20	the	the	DET
biomedich-396	134	21	correlating	correlating	NOUN
biomedich-396	134	22	or	or	CCONJ
biomedich-396	134	23	interacting	interact	VERB
biomedich-396	134	24	residues	residue	NOUN
biomedich-396	134	25	,	,	PUNCT
biomedich-396	134	26	white	white	ADJ
biomedich-396	134	27	areas	area	NOUN
biomedich-396	134	28	demonstrating	demonstrate	VERB
biomedich-396	134	29	the	the	DET
biomedich-396	134	30	residues	residue	NOUN
biomedich-396	134	31	with	with	ADP
biomedich-396	134	32	no	no	DET
biomedich-396	134	33	interactions	interaction	NOUN
biomedich-396	134	34	,	,	PUNCT
biomedich-396	134	35	and	and	CCONJ
biomedich-396	134	36	blue	blue	ADJ
biomedich-396	134	37	areas	area	NOUN
biomedich-396	134	38	showing	show	VERB
biomedich-396	134	39	residues	residue	NOUN
biomedich-396	134	40	with	with	ADP
biomedich-396	134	41	repulsive	repulsive	ADJ
biomedich-396	134	42	behaviour	behaviour	NOUN
biomedich-396	134	43	within	within	ADP
biomedich-396	134	44	the	the	DET
biomedich-396	134	45	protein	protein	NOUN
biomedich-396	134	46	molecule	molecule	NOUN
biomedich-396	134	47	.	.	PUNCT
biomedich-396	135	1	the	the	DET
biomedich-396	135	2	elastic	elastic	ADJ
biomedich-396	135	3	network	network	NOUN
biomedich-396	135	4	provides	provide	VERB
biomedich-396	135	5	an	an	DET
biomedich-396	135	6	estimate	estimate	NOUN
biomedich-396	135	7	regarding	regard	VERB
biomedich-396	135	8	the	the	DET
biomedich-396	135	9	ease	ease	NOUN
biomedich-396	135	10	of	of	ADP
biomedich-396	135	11	deformation	deformation	NOUN
biomedich-396	135	12	of	of	ADP
biomedich-396	135	13	the	the	DET
biomedich-396	135	14	target	target	NOUN
biomedich-396	135	15	amino	amino	NOUN
biomedich-396	135	16	acid	acid	NOUN
biomedich-396	135	17	residues	residue	NOUN
biomedich-396	135	18	within	within	ADP
biomedich-396	135	19	the	the	DET
biomedich-396	135	20	macromolecule	macromolecule	NOUN
biomedich-396	135	21	.	.	PUNCT
biomedich-396	136	1	the	the	DET
biomedich-396	136	2	dark	dark	ADJ
biomedich-396	136	3	greyish	greyish	ADJ
biomedich-396	136	4	areas	area	NOUN
biomedich-396	136	5	show	show	VERB
biomedich-396	136	6	residues	residue	NOUN
biomedich-396	136	7	with	with	ADP
biomedich-396	136	8	a	a	DET
biomedich-396	136	9	higher	high	ADJ
biomedich-396	136	10	degree	degree	NOUN
biomedich-396	136	11	of	of	ADP
biomedich-396	136	12	stiffness	stiffness	NOUN
biomedich-396	136	13	,	,	PUNCT
biomedich-396	136	14	while	while	SCONJ
biomedich-396	136	15	the	the	DET
biomedich-396	136	16	lighter	light	ADJ
biomedich-396	136	17	areas	area	NOUN
biomedich-396	136	18	depict	depict	VERB
biomedich-396	136	19	ease	ease	NOUN
biomedich-396	136	20	of	of	ADP
biomedich-396	136	21	deformation	deformation	NOUN
biomedich-396	136	22	of	of	ADP
biomedich-396	136	23	the	the	DET
biomedich-396	136	24	target	target	NOUN
biomedich-396	136	25	residues	residue	NOUN
biomedich-396	136	26	.	.	PUNCT
biomedich-396	137	1	448	448	NUM
biomedich-396	137	2	biology	biology	NOUN
biomedich-396	137	3	,	,	PUNCT
biomedich-396	137	4	medicine	medicine	NOUN
biomedich-396	137	5	,	,	PUNCT
biomedich-396	137	6	&	&	CCONJ
biomedich-396	137	7	natural	natural	ADJ
biomedich-396	137	8	product	product	NOUN
biomedich-396	137	9	chemistry	chemistry	NOUN
biomedich-396	137	10	12	12	NUM
biomedich-396	137	11	(	(	PUNCT
biomedich-396	137	12	2	2	NUM
biomedich-396	137	13	)	)	PUNCT
biomedich-396	137	14	,	,	PUNCT
biomedich-396	137	15	2023	2023	NUM
biomedich-396	137	16	:	:	PUNCT
biomedich-396	137	17	441	441	NUM
biomedich-396	137	18	-	-	SYM
biomedich-396	137	19	450	450	NUM
biomedich-396	137	20	figure	figure	NOUN
biomedich-396	137	21	8	8	NUM
biomedich-396	137	22	.	.	PUNCT
biomedich-396	138	1	the	the	DET
biomedich-396	138	2	image	image	NOUN
biomedich-396	138	3	(	(	PUNCT
biomedich-396	138	4	a	a	PRON
biomedich-396	138	5	)	)	PUNCT
biomedich-396	138	6	displays	display	VERB
biomedich-396	138	7	the	the	DET
biomedich-396	138	8	covariance	covariance	NOUN
biomedich-396	138	9	graph	graph	NOUN
biomedich-396	138	10	of	of	ADP
biomedich-396	138	11	the	the	DET
biomedich-396	138	12	complex	complex	NOUN
biomedich-396	138	13	(	(	PUNCT
biomedich-396	138	14	c1	c1	NOUN
biomedich-396	138	15	and	and	CCONJ
biomedich-396	138	16	macromolecule	macromolecule	NOUN
biomedich-396	138	17	)	)	PUNCT
biomedich-396	138	18	while	while	SCONJ
biomedich-396	138	19	image	image	NOUN
biomedich-396	138	20	(	(	PUNCT
biomedich-396	138	21	b	b	NOUN
biomedich-396	138	22	)	)	PUNCT
biomedich-396	138	23	represents	represent	VERB
biomedich-396	138	24	elastic	elastic	ADJ
biomedich-396	138	25	network	network	NOUN
biomedich-396	138	26	map	map	NOUN
biomedich-396	138	27	of	of	ADP
biomedich-396	138	28	the	the	DET
biomedich-396	138	29	complex	complex	ADJ
biomedich-396	138	30	.	.	PUNCT
biomedich-396	139	1	discussion	discussion	NOUN
biomedich-396	139	2	in	in	ADP
biomedich-396	139	3	this	this	DET
biomedich-396	139	4	study	study	NOUN
biomedich-396	139	5	,	,	PUNCT
biomedich-396	139	6	five	five	NUM
biomedich-396	139	7	alkaloids	alkaloid	NOUN
biomedich-396	139	8	were	be	AUX
biomedich-396	139	9	screened	screen	VERB
biomedich-396	139	10	computationally	computationally	ADV
biomedich-396	139	11	for	for	ADP
biomedich-396	139	12	their	their	PRON
biomedich-396	139	13	potential	potential	NOUN
biomedich-396	139	14	to	to	PART
biomedich-396	139	15	inhibit	inhibit	VERB
biomedich-396	139	16	the	the	DET
biomedich-396	139	17	mycobacterial	mycobacterial	ADJ
biomedich-396	139	18	acyl	acyl	NOUN
biomedich-396	139	19	carrier	carrier	NOUN
biomedich-396	139	20	protein	protein	NOUN
biomedich-396	139	21	reductase	reductase	NOUN
biomedich-396	139	22	and	and	CCONJ
biomedich-396	139	23	attenuate	attenuate	VERB
biomedich-396	139	24	tuberculosis	tuberculosis	NOUN
biomedich-396	139	25	.	.	PUNCT
biomedich-396	140	1	molecular	molecular	ADJ
biomedich-396	140	2	docking	docking	NOUN
biomedich-396	140	3	and	and	CCONJ
biomedich-396	140	4	scoring	scoring	NOUN
biomedich-396	140	5	is	be	AUX
biomedich-396	140	6	a	a	DET
biomedich-396	140	7	reasonable	reasonable	ADJ
biomedich-396	140	8	method	method	NOUN
biomedich-396	140	9	to	to	PART
biomedich-396	140	10	analyse	analyse	VERB
biomedich-396	140	11	various	various	ADJ
biomedich-396	140	12	drug	drug	NOUN
biomedich-396	140	13	candidates	candidate	NOUN
biomedich-396	140	14	for	for	ADP
biomedich-396	140	15	their	their	PRON
biomedich-396	140	16	potential	potential	NOUN
biomedich-396	140	17	for	for	ADP
biomedich-396	140	18	particular	particular	ADJ
biomedich-396	140	19	biological	biological	ADJ
biomedich-396	140	20	activity	activity	NOUN
biomedich-396	140	21	before	before	ADP
biomedich-396	140	22	entering	enter	VERB
biomedich-396	140	23	the	the	DET
biomedich-396	140	24	wet	wet	ADJ
biomedich-396	140	25	lab	lab	NOUN
biomedich-396	140	26	(	(	PUNCT
biomedich-396	140	27	torres	torre	NOUN
biomedich-396	140	28	,	,	PUNCT
biomedich-396	140	29	sodero	sodero	NOUN
biomedich-396	140	30	,	,	PUNCT
biomedich-396	140	31	&	&	CCONJ
biomedich-396	140	32	jofily	jofily	ADV
biomedich-396	140	33	,	,	PUNCT
biomedich-396	140	34	2019	2019	NUM
biomedich-396	140	35	)	)	PUNCT
biomedich-396	140	36	.	.	PUNCT
biomedich-396	141	1	the	the	DET
biomedich-396	141	2	results	result	NOUN
biomedich-396	141	3	of	of	ADP
biomedich-396	141	4	the	the	DET
biomedich-396	141	5	molecular	molecular	ADJ
biomedich-396	141	6	docking	docking	NOUN
biomedich-396	141	7	analysis	analysis	NOUN
biomedich-396	141	8	illustrated	illustrate	VERB
biomedich-396	141	9	optimistic	optimistic	ADJ
biomedich-396	141	10	outcomes	outcome	NOUN
biomedich-396	141	11	.	.	PUNCT
biomedich-396	142	1	all	all	DET
biomedich-396	142	2	five	five	NUM
biomedich-396	142	3	compounds	compound	NOUN
biomedich-396	142	4	exhibited	exhibit	VERB
biomedich-396	142	5	strong	strong	ADJ
biomedich-396	142	6	interactions	interaction	NOUN
biomedich-396	142	7	with	with	ADP
biomedich-396	142	8	the	the	DET
biomedich-396	142	9	target	target	NOUN
biomedich-396	142	10	protein	protein	NOUN
biomedich-396	142	11	.	.	PUNCT
biomedich-396	143	1	the	the	DET
biomedich-396	143	2	binding	bind	VERB
biomedich-396	143	3	energies	energy	NOUN
biomedich-396	143	4	of	of	ADP
biomedich-396	143	5	the	the	DET
biomedich-396	143	6	best	good	ADJ
biomedich-396	143	7	poses	pose	NOUN
biomedich-396	143	8	of	of	ADP
biomedich-396	143	9	these	these	DET
biomedich-396	143	10	potential	potential	ADJ
biomedich-396	143	11	drug	drug	NOUN
biomedich-396	143	12	candidates	candidate	NOUN
biomedich-396	143	13	were	be	AUX
biomedich-396	143	14	in	in	ADP
biomedich-396	143	15	a	a	DET
biomedich-396	143	16	range	range	NOUN
biomedich-396	143	17	of	of	ADP
biomedich-396	143	18	-10	-10	PUNCT
biomedich-396	143	19	to	to	ADP
biomedich-396	143	20	-9.1	-9.1	PROPN
biomedich-396	143	21	kcal	kcal	PROPN
biomedich-396	143	22	/	/	SYM
biomedich-396	143	23	mol	mol	PROPN
biomedich-396	143	24	.	.	PROPN
biomedich-396	143	25	protopine	protopine	PROPN
biomedich-396	143	26	(	(	PUNCT
biomedich-396	143	27	c1	c1	PROPN
biomedich-396	143	28	)	)	PUNCT
biomedich-396	143	29	provided	provide	VERB
biomedich-396	143	30	most	most	ADV
biomedich-396	143	31	suitable	suitable	ADJ
biomedich-396	143	32	binding	bind	VERB
biomedich-396	143	33	energies	energy	NOUN
biomedich-396	143	34	and	and	CCONJ
biomedich-396	143	35	poses	pose	NOUN
biomedich-396	143	36	.	.	PUNCT
biomedich-396	144	1	strong	strong	ADJ
biomedich-396	144	2	bonds	bond	NOUN
biomedich-396	144	3	with	with	ADP
biomedich-396	144	4	catalytic	catalytic	ADJ
biomedich-396	144	5	amino	amino	NOUN
biomedich-396	144	6	acid	acid	NOUN
biomedich-396	144	7	residues	residue	NOUN
biomedich-396	144	8	having	have	VERB
biomedich-396	144	9	considerably	considerably	ADV
biomedich-396	144	10	shorter	short	ADJ
biomedich-396	144	11	bond	bond	NOUN
biomedich-396	144	12	lengths	length	NOUN
biomedich-396	144	13	were	be	AUX
biomedich-396	144	14	observed	observe	VERB
biomedich-396	144	15	with	with	ADP
biomedich-396	144	16	all	all	DET
biomedich-396	144	17	five	five	NUM
biomedich-396	144	18	compounds	compound	NOUN
biomedich-396	144	19	.	.	PUNCT
biomedich-396	145	1	the	the	DET
biomedich-396	145	2	compounds	compound	NOUN
biomedich-396	145	3	showed	show	VERB
biomedich-396	145	4	firm	firm	ADJ
biomedich-396	145	5	interactions	interaction	NOUN
biomedich-396	145	6	with	with	ADP
biomedich-396	145	7	phe	phe	PROPN
biomedich-396	145	8	41	41	NUM
biomedich-396	145	9	,	,	PUNCT
biomedich-396	145	10	ile	ile	PROPN
biomedich-396	145	11	95	95	NUM
biomedich-396	145	12	,	,	PUNCT
biomedich-396	145	13	and	and	CCONJ
biomedich-396	145	14	ser	ser	NOUN
biomedich-396	145	15	20	20	NUM
biomedich-396	145	16	residues	residue	NOUN
biomedich-396	145	17	.	.	PUNCT
biomedich-396	146	1	the	the	DET
biomedich-396	146	2	compounds	compound	NOUN
biomedich-396	146	3	(	(	PUNCT
biomedich-396	146	4	c1	c1	PROPN
biomedich-396	146	5	–	–	PUNCT
biomedich-396	146	6	c5	c5	PROPN
biomedich-396	146	7	)	)	PUNCT
biomedich-396	146	8	were	be	AUX
biomedich-396	146	9	alkaloids	alkaloid	NOUN
biomedich-396	146	10	with	with	ADP
biomedich-396	146	11	multiple	multiple	ADJ
biomedich-396	146	12	botanical	botanical	ADJ
biomedich-396	146	13	sources	source	NOUN
biomedich-396	146	14	and	and	CCONJ
biomedich-396	146	15	a	a	DET
biomedich-396	146	16	vast	vast	ADJ
biomedich-396	146	17	range	range	NOUN
biomedich-396	146	18	of	of	ADP
biomedich-396	146	19	biological	biological	ADJ
biomedich-396	146	20	activities	activity	NOUN
biomedich-396	146	21	.	.	PUNCT
biomedich-396	147	1	protopine	protopine	NOUN
biomedich-396	147	2	(	(	PUNCT
biomedich-396	147	3	c1	c1	PROPN
biomedich-396	147	4	)	)	PUNCT
biomedich-396	147	5	is	be	AUX
biomedich-396	147	6	obtained	obtain	VERB
biomedich-396	147	7	from	from	ADP
biomedich-396	147	8	papaver	papaver	PROPN
biomedich-396	147	9	somniferum	somniferum	NOUN
biomedich-396	147	10	(	(	PUNCT
biomedich-396	147	11	pubchem	pubchem	NOUN
biomedich-396	147	12	,	,	PUNCT
biomedich-396	147	13	2023	2023	NUM
biomedich-396	147	14	)	)	PUNCT
biomedich-396	147	15	.	.	PUNCT
biomedich-396	148	1	the	the	DET
biomedich-396	148	2	compound	compound	NOUN
biomedich-396	148	3	has	have	AUX
biomedich-396	148	4	also	also	ADV
biomedich-396	148	5	been	be	AUX
biomedich-396	148	6	tested	test	VERB
biomedich-396	148	7	for	for	ADP
biomedich-396	148	8	its	its	PRON
biomedich-396	148	9	potential	potential	ADJ
biomedich-396	148	10	biological	biological	ADJ
biomedich-396	148	11	activity	activity	NOUN
biomedich-396	148	12	against	against	ADP
biomedich-396	148	13	cancer	cancer	NOUN
biomedich-396	148	14	,	,	PUNCT
biomedich-396	148	15	alzheimer	alzheimer	PROPN
biomedich-396	148	16	’s	’s	PART
biomedich-396	148	17	disease	disease	NOUN
biomedich-396	148	18	,	,	PUNCT
biomedich-396	148	19	inflammation	inflammation	NOUN
biomedich-396	148	20	and	and	CCONJ
biomedich-396	148	21	other	other	ADJ
biomedich-396	148	22	ailments	ailment	NOUN
biomedich-396	148	23	(	(	PUNCT
biomedich-396	148	24	son	son	NOUN
biomedich-396	148	25	et	et	PROPN
biomedich-396	148	26	al	al	PROPN
biomedich-396	148	27	.	.	PROPN
biomedich-396	148	28	,	,	PUNCT
biomedich-396	148	29	2019	2019	NUM
biomedich-396	148	30	;	;	PUNCT
biomedich-396	148	31	sreenivasmurthy	sreenivasmurthy	NOUN
biomedich-396	148	32	et	et	PROPN
biomedich-396	148	33	al	al	PROPN
biomedich-396	148	34	.	.	PROPN
biomedich-396	148	35	,	,	PUNCT
biomedich-396	148	36	2022	2022	NUM
biomedich-396	148	37	;	;	PUNCT
biomedich-396	149	1	zhang	zhang	PROPN
biomedich-396	149	2	et	et	PROPN
biomedich-396	149	3	al	al	PROPN
biomedich-396	149	4	.	.	PROPN
biomedich-396	149	5	,	,	PUNCT
biomedich-396	149	6	2019	2019	NUM
biomedich-396	149	7	)	)	PUNCT
biomedich-396	149	8	.	.	PUNCT
biomedich-396	150	1	in	in	ADP
biomedich-396	150	2	this	this	DET
biomedich-396	150	3	study	study	NOUN
biomedich-396	150	4	,	,	PUNCT
biomedich-396	150	5	the	the	DET
biomedich-396	150	6	protopine	protopine	NOUN
biomedich-396	150	7	has	have	AUX
biomedich-396	150	8	been	be	AUX
biomedich-396	150	9	tested	test	VERB
biomedich-396	150	10	in	in	ADP
biomedich-396	150	11	-	-	PUNCT
biomedich-396	150	12	silico	silico	NOUN
biomedich-396	150	13	for	for	ADP
biomedich-396	150	14	its	its	PRON
biomedich-396	150	15	potential	potential	ADJ
biomedich-396	150	16	anti	anti	ADJ
biomedich-396	150	17	-	-	ADJ
biomedich-396	150	18	mycobacterial	mycobacterial	ADJ
biomedich-396	150	19	effect	effect	NOUN
biomedich-396	150	20	and	and	CCONJ
biomedich-396	150	21	auspicious	auspicious	ADJ
biomedich-396	150	22	results	result	NOUN
biomedich-396	150	23	have	have	AUX
biomedich-396	150	24	been	be	AUX
biomedich-396	150	25	furnished	furnish	VERB
biomedich-396	150	26	in	in	ADP
biomedich-396	150	27	this	this	DET
biomedich-396	150	28	regard	regard	NOUN
biomedich-396	150	29	.	.	PUNCT
biomedich-396	151	1	the	the	DET
biomedich-396	151	2	second	second	ADJ
biomedich-396	151	3	drug	drug	NOUN
biomedich-396	151	4	candidate	candidate	NOUN
biomedich-396	151	5	,	,	PUNCT
biomedich-396	151	6	aporphine	aporphine	PROPN
biomedich-396	151	7	(	(	PUNCT
biomedich-396	151	8	c2	c2	PROPN
biomedich-396	151	9	)	)	PUNCT
biomedich-396	151	10	has	have	AUX
biomedich-396	151	11	been	be	AUX
biomedich-396	151	12	widely	widely	ADV
biomedich-396	151	13	tested	test	VERB
biomedich-396	151	14	for	for	ADP
biomedich-396	151	15	its	its	PRON
biomedich-396	151	16	anti	anti	ADJ
biomedich-396	151	17	-	-	ADJ
biomedich-396	151	18	inflammatory	inflammatory	ADJ
biomedich-396	151	19	,	,	PUNCT
biomedich-396	151	20	analgesic	analgesic	ADJ
biomedich-396	151	21	,	,	PUNCT
biomedich-396	151	22	antiparasitic	antiparasitic	ADJ
biomedich-396	151	23	and	and	CCONJ
biomedich-396	151	24	anti	anti	ADJ
biomedich-396	151	25	-	-	ADJ
biomedich-396	151	26	oxidant	oxidant	ADJ
biomedich-396	151	27	effects	effect	NOUN
biomedich-396	151	28	in	in	ADP
biomedich-396	151	29	various	various	ADJ
biomedich-396	151	30	in	in	ADP
biomedich-396	151	31	-	-	PUNCT
biomedich-396	151	32	silico	silico	NOUN
biomedich-396	151	33	,	,	PUNCT
biomedich-396	151	34	invitro	invitro	NOUN
biomedich-396	151	35	and	and	CCONJ
biomedich-396	151	36	in	in	ADP
biomedich-396	151	37	-	-	PUNCT
biomedich-396	151	38	vivo	vivo	NOUN
biomedich-396	151	39	models	model	NOUN
biomedich-396	151	40	(	(	PUNCT
biomedich-396	151	41	pieper	pieper	NOUN
biomedich-396	151	42	,	,	PUNCT
biomedich-396	151	43	mchugh	mchugh	PROPN
biomedich-396	151	44	,	,	PUNCT
biomedich-396	151	45	amaral	amaral	PROPN
biomedich-396	151	46	,	,	PUNCT
biomedich-396	151	47	tempone	tempone	NOUN
biomedich-396	151	48	,	,	PUNCT
biomedich-396	151	49	&	&	CCONJ
biomedich-396	151	50	anderson	anderson	PROPN
biomedich-396	151	51	,	,	PUNCT
biomedich-396	151	52	2020	2020	NUM
biomedich-396	151	53	;	;	PUNCT
biomedich-396	151	54	b.	b.	PROPN
biomedich-396	151	55	wang	wang	PROPN
biomedich-396	151	56	et	et	PROPN
biomedich-396	151	57	al	al	PROPN
biomedich-396	151	58	.	.	PROPN
biomedich-396	151	59	,	,	PUNCT
biomedich-396	151	60	2019	2019	NUM
biomedich-396	151	61	;	;	PUNCT
biomedich-396	151	62	r.	r.	PROPN
biomedich-396	151	63	wang	wang	PROPN
biomedich-396	151	64	,	,	PUNCT
biomedich-396	151	65	zhou	zhou	PROPN
biomedich-396	151	66	,	,	PUNCT
biomedich-396	151	67	shi	shi	PROPN
biomedich-396	151	68	,	,	PUNCT
biomedich-396	151	69	liu	liu	PROPN
biomedich-396	151	70	,	,	PUNCT
biomedich-396	151	71	&	&	CCONJ
biomedich-396	151	72	yu	yu	PROPN
biomedich-396	151	73	,	,	PUNCT
biomedich-396	151	74	2020	2020	NUM
biomedich-396	151	75	)	)	PUNCT
biomedich-396	151	76	.	.	PUNCT
biomedich-396	152	1	the	the	DET
biomedich-396	152	2	exploration	exploration	NOUN
biomedich-396	152	3	of	of	ADP
biomedich-396	152	4	anti	anti	ADJ
biomedich-396	152	5	-	-	ADJ
biomedich-396	152	6	tuberculosis	tuberculosis	ADJ
biomedich-396	152	7	activity	activity	NOUN
biomedich-396	152	8	was	be	AUX
biomedich-396	152	9	done	do	VERB
biomedich-396	152	10	in	in	ADP
biomedich-396	152	11	this	this	DET
biomedich-396	152	12	study	study	NOUN
biomedich-396	152	13	and	and	CCONJ
biomedich-396	152	14	promising	promise	VERB
biomedich-396	152	15	outcomes	outcome	NOUN
biomedich-396	152	16	were	be	AUX
biomedich-396	152	17	witnessed	witness	VERB
biomedich-396	152	18	.	.	PUNCT
biomedich-396	153	1	the	the	DET
biomedich-396	153	2	biological	biological	ADJ
biomedich-396	153	3	activity	activity	NOUN
biomedich-396	153	4	of	of	ADP
biomedich-396	153	5	avicine	avicine	NOUN
biomedich-396	153	6	(	(	PUNCT
biomedich-396	153	7	c3	c3	PROPN
biomedich-396	153	8	)	)	PUNCT
biomedich-396	153	9	in	in	ADP
biomedich-396	153	10	alzheimer	alzheimer	PROPN
biomedich-396	153	11	’s	’s	PART
biomedich-396	153	12	disease	disease	NOUN
biomedich-396	153	13	is	be	AUX
biomedich-396	153	14	well	well	ADV
biomedich-396	153	15	established	establish	VERB
biomedich-396	153	16	through	through	ADP
biomedich-396	153	17	animal	animal	NOUN
biomedich-396	153	18	models	model	NOUN
biomedich-396	153	19	(	(	PUNCT
biomedich-396	153	20	cahlíková	cahlíková	X
biomedich-396	153	21	et	et	PROPN
biomedich-396	153	22	al	al	PROPN
biomedich-396	153	23	.	.	PROPN
biomedich-396	153	24	,	,	PUNCT
biomedich-396	153	25	2021	2021	NUM
biomedich-396	153	26	;	;	PUNCT
biomedich-396	153	27	plazas	plaza	NOUN
biomedich-396	153	28	,	,	PUNCT
biomedich-396	153	29	2020	2020	NUM
biomedich-396	153	30	)	)	PUNCT
biomedich-396	153	31	.	.	PUNCT
biomedich-396	154	1	avicine	avicine	PROPN
biomedich-396	154	2	has	have	AUX
biomedich-396	154	3	also	also	ADV
biomedich-396	154	4	displayed	display	VERB
biomedich-396	154	5	hopeful	hopeful	ADJ
biomedich-396	154	6	anti	anti	ADJ
biomedich-396	154	7	-	-	ADJ
biomedich-396	154	8	mycobacterial	mycobacterial	ADJ
biomedich-396	154	9	activity	activity	NOUN
biomedich-396	154	10	predictions	prediction	NOUN
biomedich-396	154	11	in	in	ADP
biomedich-396	154	12	this	this	DET
biomedich-396	154	13	study	study	NOUN
biomedich-396	154	14	.	.	PUNCT
biomedich-396	155	1	penduline	penduline	NOUN
biomedich-396	155	2	(	(	PUNCT
biomedich-396	155	3	c4	c4	NOUN
biomedich-396	155	4	)	)	PUNCT
biomedich-396	155	5	has	have	AUX
biomedich-396	155	6	been	be	AUX
biomedich-396	155	7	studied	study	VERB
biomedich-396	155	8	for	for	ADP
biomedich-396	155	9	its	its	PRON
biomedich-396	155	10	anti	anti	ADJ
biomedich-396	155	11	-	-	NOUN
biomedich-396	155	12	cancer	cancer	ADJ
biomedich-396	155	13	and	and	CCONJ
biomedich-396	155	14	anti	anti	ADJ
biomedich-396	155	15	-	-	ADJ
biomedich-396	155	16	inflammatory	inflammatory	ADJ
biomedich-396	155	17	activities	activity	NOUN
biomedich-396	155	18	while	while	SCONJ
biomedich-396	155	19	chelerythrine	chelerythrine	NOUN
biomedich-396	155	20	(	(	PUNCT
biomedich-396	155	21	c5	c5	PROPN
biomedich-396	155	22	)	)	PUNCT
biomedich-396	155	23	,	,	PUNCT
biomedich-396	155	24	a	a	DET
biomedich-396	155	25	potent	potent	ADJ
biomedich-396	155	26	inhibitor	inhibitor	NOUN
biomedich-396	155	27	of	of	ADP
biomedich-396	155	28	protein	protein	NOUN
biomedich-396	155	29	kinase	kinase	PROPN
biomedich-396	155	30	c	c	PROPN
biomedich-396	155	31	,	,	PUNCT
biomedich-396	155	32	has	have	AUX
biomedich-396	155	33	revealed	reveal	VERB
biomedich-396	155	34	to	to	PART
biomedich-396	155	35	be	be	AUX
biomedich-396	155	36	active	active	ADJ
biomedich-396	155	37	against	against	ADP
biomedich-396	155	38	cancer	cancer	NOUN
biomedich-396	155	39	,	,	PUNCT
biomedich-396	155	40	bacterial	bacterial	ADJ
biomedich-396	155	41	infections	infection	NOUN
biomedich-396	155	42	and	and	CCONJ
biomedich-396	155	43	covid	covid	VERB
biomedich-396	155	44	19	19	NUM
biomedich-396	155	45	(	(	PUNCT
biomedich-396	155	46	gong	gong	NOUN
biomedich-396	155	47	et	et	PROPN
biomedich-396	155	48	al	al	PROPN
biomedich-396	155	49	.	.	PROPN
biomedich-396	155	50	,	,	PUNCT
biomedich-396	155	51	2019	2019	NUM
biomedich-396	155	52	;	;	PUNCT
biomedich-396	156	1	grabarska	grabarska	NOUN
biomedich-396	156	2	et	et	PROPN
biomedich-396	156	3	al	al	PROPN
biomedich-396	156	4	.	.	PROPN
biomedich-396	156	5	,	,	PUNCT
biomedich-396	156	6	2021	2021	NUM
biomedich-396	156	7	;	;	PUNCT
biomedich-396	156	8	lin	lin	PROPN
biomedich-396	156	9	et	et	PROPN
biomedich-396	156	10	al	al	PROPN
biomedich-396	156	11	.	.	PROPN
biomedich-396	156	12	,	,	PUNCT
biomedich-396	156	13	2017	2017	NUM
biomedich-396	156	14	;	;	PUNCT
biomedich-396	156	15	valipour	valipour	NUM
biomedich-396	156	16	et	et	PROPN
biomedich-396	156	17	al	al	PROPN
biomedich-396	156	18	.	.	PROPN
biomedich-396	156	19	2021	2021	NUM
biomedich-396	156	20	)	)	PUNCT
biomedich-396	156	21	.	.	PUNCT
biomedich-396	157	1	both	both	PRON
biomedich-396	157	2	of	of	ADP
biomedich-396	157	3	these	these	DET
biomedich-396	157	4	alkaloids	alkaloid	NOUN
biomedich-396	157	5	have	have	AUX
biomedich-396	157	6	furnished	furnish	VERB
biomedich-396	157	7	significant	significant	ADJ
biomedich-396	157	8	results	result	NOUN
biomedich-396	157	9	in	in	ADP
biomedich-396	157	10	the	the	DET
biomedich-396	157	11	molecular	molecular	ADJ
biomedich-396	157	12	docking	docking	NOUN
biomedich-396	157	13	analysis	analysis	NOUN
biomedich-396	157	14	in	in	ADP
biomedich-396	157	15	this	this	DET
biomedich-396	157	16	study	study	NOUN
biomedich-396	157	17	.	.	PUNCT
biomedich-396	158	1	the	the	DET
biomedich-396	158	2	molecular	molecular	ADJ
biomedich-396	158	3	dynamics	dynamic	NOUN
biomedich-396	158	4	simulations	simulation	NOUN
biomedich-396	158	5	have	have	AUX
biomedich-396	158	6	further	far	ADV
biomedich-396	158	7	explored	explore	VERB
biomedich-396	158	8	the	the	DET
biomedich-396	158	9	dynamic	dynamic	ADJ
biomedich-396	158	10	behavior	behavior	NOUN
biomedich-396	158	11	of	of	ADP
biomedich-396	158	12	the	the	DET
biomedich-396	158	13	targeted	target	VERB
biomedich-396	158	14	protein	protein	NOUN
biomedich-396	158	15	.	.	PUNCT
biomedich-396	159	1	isoniazid	isoniazid	PROPN
biomedich-396	159	2	is	be	AUX
biomedich-396	159	3	a	a	DET
biomedich-396	159	4	well	well	ADV
biomedich-396	159	5	-	-	PUNCT
biomedich-396	159	6	known	know	VERB
biomedich-396	159	7	inhibitor	inhibitor	NOUN
biomedich-396	159	8	of	of	ADP
biomedich-396	159	9	mycobacterial	mycobacterial	ADJ
biomedich-396	159	10	enoyl	enoyl	NOUN
biomedich-396	159	11	-	-	PUNCT
biomedich-396	159	12	acp	acp	PROPN
biomedich-396	159	13	reductase	reductase	NOUN
biomedich-396	159	14	(	(	PUNCT
biomedich-396	159	15	unissa	unissa	PROPN
biomedich-396	159	16	et	et	PROPN
biomedich-396	159	17	al	al	PROPN
biomedich-396	159	18	,	,	PUNCT
biomedich-396	159	19	2016	2016	NUM
biomedich-396	159	20	)	)	PUNCT
biomedich-396	159	21	.	.	PUNCT
biomedich-396	160	1	isoniazid	isoniazid	PROPN
biomedich-396	160	2	inhibits	inhibit	VERB
biomedich-396	160	3	the	the	DET
biomedich-396	160	4	synthesis	synthesis	NOUN
biomedich-396	160	5	of	of	ADP
biomedich-396	160	6	mycolic	mycolic	ADJ
biomedich-396	160	7	acid	acid	NOUN
biomedich-396	160	8	in	in	ADP
biomedich-396	160	9	mycobacteria	mycobacterium	NOUN
biomedich-396	160	10	and	and	CCONJ
biomedich-396	160	11	halts	halt	VERB
biomedich-396	160	12	the	the	DET
biomedich-396	160	13	progression	progression	NOUN
biomedich-396	160	14	of	of	ADP
biomedich-396	160	15	cell	cell	NOUN
biomedich-396	160	16	wall	wall	NOUN
biomedich-396	160	17	synthesis	synthesis	PROPN
biomedich-396	160	18	,	,	PUNCT
biomedich-396	160	19	thereby	thereby	ADV
biomedich-396	160	20	providing	provide	VERB
biomedich-396	160	21	bactericidal	bactericidal	ADJ
biomedich-396	160	22	effects	effect	NOUN
biomedich-396	160	23	(	(	PUNCT
biomedich-396	160	24	vilchèze	vilchèze	PROPN
biomedich-396	160	25	&	&	CCONJ
biomedich-396	160	26	jacobs	jacobs	PROPN
biomedich-396	160	27	,	,	PUNCT
biomedich-396	160	28	2019	2019	NUM
biomedich-396	160	29	)	)	PUNCT
biomedich-396	160	30	.	.	PUNCT
biomedich-396	161	1	isoniazid	isoniazid	PROPN
biomedich-396	161	2	is	be	AUX
biomedich-396	161	3	one	one	NUM
biomedich-396	161	4	of	of	ADP
biomedich-396	161	5	the	the	DET
biomedich-396	161	6	anti	anti	ADJ
biomedich-396	161	7	-	-	ADJ
biomedich-396	161	8	tubercular	tubercular	ADJ
biomedich-396	161	9	drugs	drug	NOUN
biomedich-396	161	10	that	that	PRON
biomedich-396	161	11	have	have	AUX
biomedich-396	161	12	indicated	indicate	VERB
biomedich-396	161	13	notable	notable	ADJ
biomedich-396	161	14	efficacy	efficacy	NOUN
biomedich-396	161	15	through	through	ADP
biomedich-396	161	16	the	the	DET
biomedich-396	161	17	decades	decade	NOUN
biomedich-396	161	18	.	.	PUNCT
biomedich-396	162	1	(	(	PUNCT
biomedich-396	162	2	charan	charan	NOUN
biomedich-396	162	3	et	et	PROPN
biomedich-396	162	4	al	al	PROPN
biomedich-396	162	5	.	.	PROPN
biomedich-396	162	6	,	,	PUNCT
biomedich-396	162	7	2018	2018	NUM
biomedich-396	162	8	;	;	PUNCT
biomedich-396	162	9	huang	huang	PROPN
biomedich-396	162	10	et	et	PROPN
biomedich-396	162	11	al	al	PROPN
biomedich-396	162	12	.	.	PROPN
biomedich-396	162	13	,	,	PUNCT
biomedich-396	162	14	2018	2018	NUM
biomedich-396	162	15	;	;	PUNCT
biomedich-396	162	16	pease	pease	PROPN
biomedich-396	162	17	et	et	PROPN
biomedich-396	162	18	al	al	PROPN
biomedich-396	162	19	.	.	PROPN
biomedich-396	162	20	,	,	PUNCT
biomedich-396	162	21	2017	2017	NUM
biomedich-396	162	22	)	)	PUNCT
biomedich-396	162	23	.	.	PUNCT
biomedich-396	163	1	keeping	keep	VERB
biomedich-396	163	2	in	in	ADP
biomedich-396	163	3	view	view	NOUN
biomedich-396	163	4	these	these	DET
biomedich-396	163	5	facts	fact	NOUN
biomedich-396	163	6	,	,	PUNCT
biomedich-396	163	7	severe	severe	ADJ
biomedich-396	163	8	toxicities	toxicity	NOUN
biomedich-396	163	9	and	and	CCONJ
biomedich-396	163	10	adverse	adverse	ADJ
biomedich-396	163	11	drug	drug	NOUN
biomedich-396	163	12	reactions	reaction	NOUN
biomedich-396	163	13	are	be	AUX
biomedich-396	163	14	also	also	ADV
biomedich-396	163	15	associated	associate	VERB
biomedich-396	163	16	with	with	ADP
biomedich-396	163	17	the	the	DET
biomedich-396	163	18	use	use	NOUN
biomedich-396	163	19	of	of	ADP
biomedich-396	163	20	isoniazid	isoniazid	NOUN
biomedich-396	163	21	in	in	ADP
biomedich-396	163	22	the	the	DET
biomedich-396	163	23	treatment	treatment	NOUN
biomedich-396	163	24	regimen	regiman	NOUN
biomedich-396	163	25	for	for	ADP
biomedich-396	163	26	tuberculosis	tuberculosis	NOUN
biomedich-396	163	27	(	(	PUNCT
biomedich-396	163	28	bliven	bliven	NOUN
biomedich-396	163	29	-	-	PUNCT
biomedich-396	163	30	sizemore	sizemore	NOUN
biomedich-396	163	31	et	et	NOUN
biomedich-396	163	32	al	al	PROPN
biomedich-396	163	33	.	.	PROPN
biomedich-396	163	34	,	,	PUNCT
biomedich-396	163	35	2015	2015	NUM
biomedich-396	163	36	)	)	PUNCT
biomedich-396	163	37	.	.	PUNCT
biomedich-396	164	1	the	the	DET
biomedich-396	164	2	hepatotoxicity	hepatotoxicity	NOUN
biomedich-396	164	3	and	and	CCONJ
biomedich-396	164	4	peripheral	peripheral	ADJ
biomedich-396	164	5	neuritis	neuritis	NOUN
biomedich-396	164	6	are	be	AUX
biomedich-396	164	7	the	the	DET
biomedich-396	164	8	most	most	ADV
biomedich-396	164	9	significant	significant	ADJ
biomedich-396	164	10	toxicities	toxicity	NOUN
biomedich-396	164	11	associated	associate	VERB
biomedich-396	164	12	with	with	ADP
biomedich-396	164	13	isoniazid	isoniazid	NOUN
biomedich-396	164	14	(	(	PUNCT
biomedich-396	164	15	lamb	lamb	PROPN
biomedich-396	164	16	&	&	CCONJ
biomedich-396	164	17	mauermann	mauermann	PROPN
biomedich-396	164	18	,	,	PUNCT
biomedich-396	164	19	2021	2021	NUM
biomedich-396	164	20	;	;	PUNCT
biomedich-396	164	21	mafukidze	mafukidze	NOUN
biomedich-396	164	22	,	,	PUNCT
biomedich-396	164	23	calnan	calnan	NOUN
biomedich-396	164	24	,	,	PUNCT
biomedich-396	164	25	&	&	CCONJ
biomedich-396	164	26	furin	furin	NOUN
biomedich-396	164	27	,	,	PUNCT
biomedich-396	164	28	2016	2016	NUM
biomedich-396	164	29	;	;	PUNCT
biomedich-396	164	30	m	m	VERB
biomedich-396	164	31	russom	russom	NOUN
biomedich-396	164	32	et	et	PROPN
biomedich-396	164	33	al	al	PROPN
biomedich-396	164	34	.	.	PROPN
biomedich-396	164	35	,	,	PUNCT
biomedich-396	164	36	2019	2019	NUM
biomedich-396	164	37	;	;	PUNCT
biomedich-396	164	38	mulugeta	mulugeta	PROPN
biomedich-396	164	39	russom	russom	NOUN
biomedich-396	164	40	et	et	PROPN
biomedich-396	164	41	al	al	PROPN
biomedich-396	164	42	.	.	PROPN
biomedich-396	164	43	,	,	PUNCT
biomedich-396	164	44	2018	2018	NUM
biomedich-396	164	45	)	)	PUNCT
biomedich-396	164	46	.	.	PUNCT
biomedich-396	165	1	these	these	DET
biomedich-396	165	2	considerable	considerable	ADJ
biomedich-396	165	3	toxicities	toxicity	NOUN
biomedich-396	165	4	demand	demand	VERB
biomedich-396	165	5	a	a	DET
biomedich-396	165	6	safer	safe	ADJ
biomedich-396	165	7	treatment	treatment	NOUN
biomedich-396	165	8	option	option	NOUN
biomedich-396	165	9	with	with	ADP
biomedich-396	165	10	similar	similar	ADJ
biomedich-396	165	11	efficacy	efficacy	NOUN
biomedich-396	165	12	.	.	PUNCT
biomedich-396	166	1	in	in	ADP
biomedich-396	166	2	this	this	DET
biomedich-396	166	3	study	study	NOUN
biomedich-396	166	4	,	,	PUNCT
biomedich-396	166	5	potential	potential	ADJ
biomedich-396	166	6	drug	drug	NOUN
biomedich-396	166	7	candidates	candidate	NOUN
biomedich-396	166	8	,	,	PUNCT
biomedich-396	166	9	i.e.	i.e.	X
biomedich-396	166	10	,	,	PUNCT
biomedich-396	166	11	natural	natural	ADJ
biomedich-396	166	12	compounds	compound	NOUN
biomedich-396	166	13	(	(	PUNCT
biomedich-396	166	14	alkaloids	alkaloid	NOUN
biomedich-396	166	15	)	)	PUNCT
biomedich-396	166	16	with	with	ADP
biomedich-396	166	17	no	no	DET
biomedich-396	166	18	reported	report	VERB
biomedich-396	166	19	toxicity	toxicity	NOUN
biomedich-396	166	20	and	and	CCONJ
biomedich-396	166	21	strong	strong	ADJ
biomedich-396	166	22	affinity	affinity	NOUN
biomedich-396	166	23	for	for	ADP
biomedich-396	166	24	target	target	NOUN
biomedich-396	166	25	proteins	protein	NOUN
biomedich-396	166	26	,	,	PUNCT
biomedich-396	166	27	could	could	AUX
biomedich-396	166	28	attenuate	attenuate	VERB
biomedich-396	166	29	tuberculosis	tuberculosis	NOUN
biomedich-396	166	30	infection	infection	NOUN
biomedich-396	166	31	after	after	ADP
biomedich-396	166	32	the	the	DET
biomedich-396	166	33	development	development	NOUN
biomedich-396	166	34	of	of	ADP
biomedich-396	166	35	a	a	DET
biomedich-396	166	36	stable	stable	ADJ
biomedich-396	166	37	formulation	formulation	NOUN
biomedich-396	166	38	.	.	PUNCT
biomedich-396	167	1	this	this	DET
biomedich-396	167	2	study	study	NOUN
biomedich-396	167	3	recommends	recommend	VERB
biomedich-396	167	4	the	the	DET
biomedich-396	167	5	formulation	formulation	NOUN
biomedich-396	167	6	scientists	scientist	NOUN
biomedich-396	167	7	to	to	PART
biomedich-396	167	8	employ	employ	VERB
biomedich-396	167	9	novel	novel	ADJ
biomedich-396	167	10	drug	drug	NOUN
biomedich-396	167	11	formulation	formulation	NOUN
biomedich-396	167	12	techniques	technique	NOUN
biomedich-396	167	13	for	for	ADP
biomedich-396	167	14	formulating	formulate	VERB
biomedich-396	167	15	natural	natural	ADJ
biomedich-396	167	16	products	product	NOUN
biomedich-396	167	17	and	and	CCONJ
biomedich-396	167	18	secondary	secondary	ADJ
biomedich-396	167	19	metabolites	metabolite	NOUN
biomedich-396	167	20	such	such	ADJ
biomedich-396	167	21	as	as	ADP
biomedich-396	167	22	alkaloids	alkaloid	NOUN
biomedich-396	167	23	as	as	ADP
biomedich-396	167	24	nanocarriers	nanocarrier	NOUN
biomedich-396	167	25	in	in	ADP
biomedich-396	167	26	order	order	NOUN
biomedich-396	167	27	to	to	PART
biomedich-396	167	28	achieve	achieve	VERB
biomedich-396	167	29	their	their	PRON
biomedich-396	167	30	delivery	delivery	NOUN
biomedich-396	167	31	to	to	ADP
biomedich-396	167	32	the	the	DET
biomedich-396	167	33	targeted	target	VERB
biomedich-396	167	34	sites	site	NOUN
biomedich-396	167	35	,	,	PUNCT
biomedich-396	167	36	maintain	maintain	VERB
biomedich-396	167	37	efficacy	efficacy	NOUN
biomedich-396	167	38	and	and	CCONJ
biomedich-396	167	39	avoid	avoid	VERB
biomedich-396	167	40	any	any	DET
biomedich-396	167	41	undesirable	undesirable	ADJ
biomedich-396	167	42	or	or	CCONJ
biomedich-396	167	43	noxious	noxious	ADJ
biomedich-396	167	44	effect	effect	NOUN
biomedich-396	167	45	.	.	PUNCT
biomedich-396	168	1	natural	natural	ADJ
biomedich-396	168	2	products	product	NOUN
biomedich-396	168	3	and	and	CCONJ
biomedich-396	168	4	phytochemicals	phytochemical	NOUN
biomedich-396	168	5	have	have	AUX
biomedich-396	168	6	caught	catch	VERB
biomedich-396	168	7	the	the	DET
biomedich-396	168	8	attention	attention	NOUN
biomedich-396	168	9	of	of	ADP
biomedich-396	168	10	formulation	formulation	NOUN
biomedich-396	168	11	scientists	scientist	NOUN
biomedich-396	168	12	and	and	CCONJ
biomedich-396	168	13	pharmacologists	pharmacologist	NOUN
biomedich-396	168	14	to	to	ADP
biomedich-396	168	15	a	a	DET
biomedich-396	168	16	greater	great	ADJ
biomedich-396	168	17	extent	extent	NOUN
biomedich-396	168	18	.	.	PUNCT
biomedich-396	169	1	the	the	DET
biomedich-396	169	2	coupling	coupling	NOUN
biomedich-396	169	3	of	of	ADP
biomedich-396	169	4	natural	natural	ADJ
biomedich-396	169	5	products	product	NOUN
biomedich-396	169	6	and	and	CCONJ
biomedich-396	169	7	kamran	kamran	PROPN
biomedich-396	169	8	&	&	CCONJ
biomedich-396	169	9	ibrahim	ibrahim	PROPN
biomedich-396	169	10	–	–	PUNCT
biomedich-396	169	11	alkaloids	alkaloid	NOUN
biomedich-396	169	12	lead	lead	VERB
biomedich-396	169	13	to	to	ADP
biomedich-396	169	14	potential	potential	ADJ
biomedich-396	169	15	inhibition	inhibition	NOUN
biomedich-396	169	16	of	of	ADP
biomedich-396	169	17	the	the	DET
biomedich-396	169	18	…	…	PUNCT
biomedich-396	169	19	449	449	NUM
biomedich-396	169	20	nanomedicine	nanomedicine	NOUN
biomedich-396	169	21	can	can	AUX
biomedich-396	169	22	make	make	VERB
biomedich-396	169	23	major	major	ADJ
biomedich-396	169	24	breakthroughs	breakthrough	NOUN
biomedich-396	169	25	in	in	ADP
biomedich-396	169	26	the	the	DET
biomedich-396	169	27	field	field	NOUN
biomedich-396	169	28	of	of	ADP
biomedich-396	169	29	therapeutics	therapeutic	NOUN
biomedich-396	169	30	.	.	PUNCT
biomedich-396	170	1	this	this	DET
biomedich-396	170	2	study	study	NOUN
biomedich-396	170	3	also	also	ADV
biomedich-396	170	4	puts	put	VERB
biomedich-396	170	5	emphasis	emphasis	NOUN
biomedich-396	170	6	on	on	ADP
biomedich-396	170	7	this	this	DET
biomedich-396	170	8	idea	idea	NOUN
biomedich-396	170	9	.	.	PUNCT
biomedich-396	171	1	conclusion	conclusion	NOUN
biomedich-396	171	2	tuberculosis	tuberculosis	NOUN
biomedich-396	171	3	is	be	AUX
biomedich-396	171	4	a	a	DET
biomedich-396	171	5	public	public	ADJ
biomedich-396	171	6	health	health	NOUN
biomedich-396	171	7	concern	concern	NOUN
biomedich-396	171	8	that	that	PRON
biomedich-396	171	9	claims	claim	VERB
biomedich-396	171	10	millions	million	NOUN
biomedich-396	171	11	of	of	ADP
biomedich-396	171	12	lives	life	NOUN
biomedich-396	171	13	annually	annually	ADV
biomedich-396	171	14	.	.	PUNCT
biomedich-396	172	1	the	the	DET
biomedich-396	172	2	current	current	ADJ
biomedich-396	172	3	therapy	therapy	NOUN
biomedich-396	172	4	for	for	ADP
biomedich-396	172	5	tuberculosis	tuberculosis	NOUN
biomedich-396	172	6	has	have	VERB
biomedich-396	172	7	many	many	ADJ
biomedich-396	172	8	challenges	challenge	NOUN
biomedich-396	172	9	,	,	PUNCT
biomedich-396	172	10	with	with	ADP
biomedich-396	172	11	toxicity	toxicity	NOUN
biomedich-396	172	12	at	at	ADP
biomedich-396	172	13	the	the	DET
biomedich-396	172	14	top	top	NOUN
biomedich-396	172	15	of	of	ADP
biomedich-396	172	16	the	the	DET
biomedich-396	172	17	list	list	NOUN
biomedich-396	172	18	.	.	PUNCT
biomedich-396	173	1	natural	natural	ADJ
biomedich-396	173	2	products	product	NOUN
biomedich-396	173	3	have	have	AUX
biomedich-396	173	4	been	be	AUX
biomedich-396	173	5	used	use	VERB
biomedich-396	173	6	traditionally	traditionally	ADV
biomedich-396	173	7	owing	owe	VERB
biomedich-396	173	8	to	to	ADP
biomedich-396	173	9	their	their	PRON
biomedich-396	173	10	minimal	minimal	ADJ
biomedich-396	173	11	toxicities	toxicity	NOUN
biomedich-396	173	12	and	and	CCONJ
biomedich-396	173	13	decent	decent	ADJ
biomedich-396	173	14	efficacy	efficacy	NOUN
biomedich-396	173	15	.	.	PUNCT
biomedich-396	174	1	many	many	ADJ
biomedich-396	174	2	studies	study	NOUN
biomedich-396	174	3	have	have	AUX
biomedich-396	174	4	established	establish	VERB
biomedich-396	174	5	that	that	SCONJ
biomedich-396	174	6	phytochemicals	phytochemical	NOUN
biomedich-396	174	7	can	can	AUX
biomedich-396	174	8	attenuate	attenuate	VERB
biomedich-396	174	9	bacterial	bacterial	ADJ
biomedich-396	174	10	infections	infection	NOUN
biomedich-396	174	11	such	such	ADJ
biomedich-396	174	12	as	as	ADP
biomedich-396	174	13	tuberculosis	tuberculosis	NOUN
biomedich-396	174	14	.	.	PUNCT
biomedich-396	175	1	through	through	ADP
biomedich-396	175	2	in	in	ADP
biomedich-396	175	3	-	-	PUNCT
biomedich-396	175	4	silico	silico	NOUN
biomedich-396	175	5	analysis	analysis	NOUN
biomedich-396	175	6	,	,	PUNCT
biomedich-396	175	7	this	this	DET
biomedich-396	175	8	study	study	NOUN
biomedich-396	175	9	has	have	AUX
biomedich-396	175	10	concluded	conclude	VERB
biomedich-396	175	11	that	that	SCONJ
biomedich-396	175	12	the	the	DET
biomedich-396	175	13	alkaloids	alkaloid	NOUN
biomedich-396	175	14	such	such	ADJ
biomedich-396	175	15	as	as	ADP
biomedich-396	175	16	protopine	protopine	NOUN
biomedich-396	175	17	,	,	PUNCT
biomedich-396	175	18	aporphine	aporphine	PROPN
biomedich-396	175	19	,	,	PUNCT
biomedich-396	175	20	avicine	avicine	NOUN
biomedich-396	175	21	etc	etc	X
biomedich-396	175	22	.	.	X
biomedich-396	175	23	have	have	VERB
biomedich-396	175	24	potential	potential	ADJ
biomedich-396	175	25	inhibitory	inhibitory	ADJ
biomedich-396	175	26	activity	activity	NOUN
biomedich-396	175	27	for	for	ADP
biomedich-396	175	28	the	the	DET
biomedich-396	175	29	mycobacterial	mycobacterial	ADJ
biomedich-396	175	30	acyl	acyl	NOUN
biomedich-396	175	31	carrier	carrier	NOUN
biomedich-396	175	32	protein	protein	NOUN
biomedich-396	175	33	reductase	reductase	NOUN
biomedich-396	175	34	enzyme	enzyme	NOUN
biomedich-396	175	35	,	,	PUNCT
biomedich-396	175	36	hence	hence	ADV
biomedich-396	175	37	disrupting	disrupt	VERB
biomedich-396	175	38	mycobacterial	mycobacterial	ADJ
biomedich-396	175	39	survival	survival	NOUN
biomedich-396	175	40	and	and	CCONJ
biomedich-396	175	41	pathogenesis	pathogenesis	NOUN
biomedich-396	175	42	.	.	PUNCT
biomedich-396	176	1	the	the	DET
biomedich-396	176	2	molecular	molecular	ADJ
biomedich-396	176	3	docking	docking	NOUN
biomedich-396	176	4	and	and	CCONJ
biomedich-396	176	5	molecular	molecular	ADJ
biomedich-396	176	6	dynamics	dynamic	NOUN
biomedich-396	176	7	simulation	simulation	NOUN
biomedich-396	176	8	provided	provide	VERB
biomedich-396	176	9	optimistic	optimistic	ADJ
biomedich-396	176	10	results	result	NOUN
biomedich-396	176	11	regarding	regard	VERB
biomedich-396	176	12	the	the	DET
biomedich-396	176	13	interactions	interaction	NOUN
biomedich-396	176	14	of	of	ADP
biomedich-396	176	15	these	these	DET
biomedich-396	176	16	alkaloids	alkaloid	NOUN
biomedich-396	176	17	with	with	ADP
biomedich-396	176	18	the	the	DET
biomedich-396	176	19	active	active	ADJ
biomedich-396	176	20	amino	amino	NOUN
biomedich-396	176	21	acid	acid	NOUN
biomedich-396	176	22	residues	residue	NOUN
biomedich-396	176	23	of	of	ADP
biomedich-396	176	24	mycobacterial	mycobacterial	ADJ
biomedich-396	176	25	acyl	acyl	NOUN
biomedich-396	176	26	carrier	carrier	NOUN
biomedich-396	176	27	protein	protein	NOUN
biomedich-396	176	28	reductase	reductase	NOUN
biomedich-396	176	29	.	.	PUNCT
biomedich-396	177	1	this	this	DET
biomedich-396	177	2	study	study	NOUN
biomedich-396	177	3	recommends	recommend	VERB
biomedich-396	177	4	the	the	DET
biomedich-396	177	5	conduct	conduct	NOUN
biomedich-396	177	6	of	of	ADP
biomedich-396	177	7	in	in	ADP
biomedich-396	177	8	vitro	vitro	X
biomedich-396	177	9	and	and	CCONJ
biomedich-396	177	10	in	in	ADP
biomedich-396	177	11	vivo	vivo	ADJ
biomedich-396	177	12	studies	study	NOUN
biomedich-396	177	13	in	in	ADP
biomedich-396	177	14	order	order	NOUN
biomedich-396	177	15	to	to	PART
biomedich-396	177	16	validate	validate	VERB
biomedich-396	177	17	the	the	DET
biomedich-396	177	18	findings	finding	NOUN
biomedich-396	177	19	of	of	ADP
biomedich-396	177	20	this	this	DET
biomedich-396	177	21	research	research	NOUN
biomedich-396	177	22	study	study	NOUN
biomedich-396	177	23	and	and	CCONJ
biomedich-396	177	24	the	the	DET
biomedich-396	177	25	development	development	NOUN
biomedich-396	177	26	of	of	ADP
biomedich-396	177	27	novel	novel	ADJ
biomedich-396	177	28	formulations	formulation	NOUN
biomedich-396	177	29	for	for	ADP
biomedich-396	177	30	better	well	ADJ
biomedich-396	177	31	delivery	delivery	NOUN
biomedich-396	177	32	of	of	ADP
biomedich-396	177	33	these	these	DET
biomedich-396	177	34	alkaloids	alkaloid	NOUN
biomedich-396	177	35	for	for	ADP
biomedich-396	177	36	attenuating	attenuate	VERB
biomedich-396	177	37	tuberculosis	tuberculosis	NOUN
biomedich-396	177	38	.	.	PUNCT
biomedich-396	178	1	acknowledgements	acknowledgement	NOUN
biomedich-396	178	2	:	:	PUNCT
biomedich-396	178	3	the	the	DET
biomedich-396	178	4	study	study	NOUN
biomedich-396	178	5	is	be	AUX
biomedich-396	178	6	carried	carry	VERB
biomedich-396	178	7	out	out	ADP
biomedich-396	178	8	entirely	entirely	ADV
biomedich-396	178	9	by	by	ADP
biomedich-396	178	10	the	the	DET
biomedich-396	178	11	authors	author	NOUN
biomedich-396	178	12	,	,	PUNCT
biomedich-396	178	13	so	so	SCONJ
biomedich-396	178	14	there	there	PRON
biomedich-396	178	15	is	be	VERB
biomedich-396	178	16	no	no	DET
biomedich-396	178	17	need	need	NOUN
biomedich-396	178	18	for	for	ADP
biomedich-396	178	19	acknowledgement	acknowledgement	NOUN
biomedich-396	178	20	.	.	PUNCT
biomedich-396	179	1	authors	author	NOUN
biomedich-396	179	2	’	'	PUNCT
biomedich-396	179	3	contributions	contribution	NOUN
biomedich-396	179	4	:	:	PUNCT
biomedich-396	179	5	ahsan	ahsan	PROPN
biomedich-396	179	6	ibrahim	ibrahim	PROPN
biomedich-396	179	7	designed	design	VERB
biomedich-396	179	8	the	the	DET
biomedich-396	179	9	study	study	NOUN
biomedich-396	179	10	.	.	PUNCT
biomedich-396	180	1	pernia	pernia	PROPN
biomedich-396	180	2	kamran	kamran	PROPN
biomedich-396	180	3	and	and	CCONJ
biomedich-396	180	4	ahsan	ahsan	PROPN
biomedich-396	180	5	ibrahim	ibrahim	PROPN
biomedich-396	180	6	carried	carry	VERB
biomedich-396	180	7	out	out	ADP
biomedich-396	180	8	the	the	DET
biomedich-396	180	9	computational	computational	ADJ
biomedich-396	180	10	work	work	NOUN
biomedich-396	180	11	.	.	PUNCT
biomedich-396	181	1	pernia	pernia	PROPN
biomedich-396	181	2	kamran	kamran	PROPN
biomedich-396	181	3	&	&	CCONJ
biomedich-396	181	4	ahsan	ahsan	PROPN
biomedich-396	181	5	ibrahim	ibrahim	PROPN
biomedich-396	181	6	wrote	write	VERB
biomedich-396	181	7	the	the	DET
biomedich-396	181	8	manuscript	manuscript	NOUN
biomedich-396	181	9	.	.	PUNCT
biomedich-396	182	1	all	all	DET
biomedich-396	182	2	authors	author	NOUN
biomedich-396	182	3	read	read	VERB
biomedich-396	182	4	and	and	CCONJ
biomedich-396	182	5	approved	approve	VERB
biomedich-396	182	6	the	the	DET
biomedich-396	182	7	final	final	ADJ
biomedich-396	182	8	version	version	NOUN
biomedich-396	182	9	of	of	ADP
biomedich-396	182	10	the	the	DET
biomedich-396	182	11	manuscript	manuscript	NOUN
biomedich-396	182	12	.	.	PUNCT
biomedich-396	183	1	competing	compete	VERB
biomedich-396	183	2	interests	interest	NOUN
biomedich-396	183	3	:	:	PUNCT
biomedich-396	183	4	the	the	DET
biomedich-396	183	5	authors	author	NOUN
biomedich-396	183	6	declare	declare	VERB
biomedich-396	183	7	that	that	SCONJ
biomedich-396	183	8	there	there	PRON
biomedich-396	183	9	are	be	VERB
biomedich-396	183	10	no	no	DET
biomedich-396	183	11	competing	compete	VERB
biomedich-396	183	12	interests	interest	NOUN
biomedich-396	183	13	.	.	PUNCT
biomedich-396	184	1	references	reference	NOUN
biomedich-396	184	2	bliven	bliven	NOUN
biomedich-396	184	3	-	-	PUNCT
biomedich-396	184	4	sizemore	sizemore	NOUN
biomedich-396	184	5	,	,	PUNCT
biomedich-396	184	6	e.	e.	PROPN
biomedich-396	184	7	e.	e.	PROPN
biomedich-396	184	8	,	,	PUNCT
biomedich-396	184	9	sterling	sterling	NOUN
biomedich-396	184	10	,	,	PUNCT
biomedich-396	184	11	t.	t.	PROPN
biomedich-396	184	12	,	,	PUNCT
biomedich-396	184	13	shang	shang	PROPN
biomedich-396	184	14	,	,	PUNCT
biomedich-396	184	15	n.	n.	NOUN
biomedich-396	184	16	,	,	PUNCT
biomedich-396	184	17	benator	benator	NOUN
biomedich-396	184	18	,	,	PUNCT
biomedich-396	184	19	d.	d.	PROPN
biomedich-396	184	20	,	,	PUNCT
biomedich-396	184	21	schwartzman	schwartzman	PROPN
biomedich-396	184	22	,	,	PUNCT
biomedich-396	184	23	k.	k.	PROPN
biomedich-396	184	24	,	,	PUNCT
biomedich-396	184	25	reves	reves	PROPN
biomedich-396	184	26	,	,	PUNCT
biomedich-396	184	27	r.	r.	PROPN
biomedich-396	184	28	,	,	PUNCT
biomedich-396	184	29	.	.	PUNCT
biomedich-396	184	30	.	.	PUNCT
biomedich-396	184	31	.	.	PUNCT
biomedich-396	185	1	consortium	consortium	NOUN
biomedich-396	185	2	,	,	PUNCT
biomedich-396	185	3	t.	t.	PROPN
biomedich-396	185	4	t.	t.	PROPN
biomedich-396	185	5	(	(	PUNCT
biomedich-396	185	6	2015	2015	NUM
biomedich-396	185	7	)	)	PUNCT
biomedich-396	185	8	.	.	PUNCT
biomedich-396	186	1	three	three	NUM
biomedich-396	186	2	months	month	NOUN
biomedich-396	186	3	of	of	ADP
biomedich-396	186	4	weekly	weekly	ADJ
biomedich-396	186	5	rifapentine	rifapentine	NOUN
biomedich-396	186	6	plus	plus	CCONJ
biomedich-396	186	7	isoniazid	isoniazid	NOUN
biomedich-396	186	8	is	be	AUX
biomedich-396	186	9	less	less	ADV
biomedich-396	186	10	hepatotoxic	hepatotoxic	NOUN
biomedich-396	186	11	than	than	ADP
biomedich-396	186	12	nine	nine	NUM
biomedich-396	186	13	months	month	NOUN
biomedich-396	186	14	of	of	ADP
biomedich-396	186	15	daily	daily	ADJ
biomedich-396	186	16	isoniazid	isoniazid	NOUN
biomedich-396	186	17	for	for	ADP
biomedich-396	186	18	ltbi	ltbi	NOUN
biomedich-396	186	19	.	.	PUNCT
biomedich-396	187	1	the	the	DET
biomedich-396	187	2	international	international	ADJ
biomedich-396	187	3	journal	journal	NOUN
biomedich-396	187	4	of	of	ADP
biomedich-396	187	5	tuberculosis	tuberculosis	NOUN
biomedich-396	187	6	and	and	CCONJ
biomedich-396	187	7	lung	lung	NOUN
biomedich-396	187	8	disease	disease	NOUN
biomedich-396	187	9	,	,	PUNCT
biomedich-396	187	10	19(9	19(9	NUM
biomedich-396	187	11	)	)	PUNCT
biomedich-396	187	12	,	,	PUNCT
biomedich-396	187	13	1039	1039	NUM
biomedich-396	187	14	-	-	SYM
biomedich-396	187	15	1044	1044	NUM
biomedich-396	187	16	.	.	PUNCT
biomedich-396	188	1	cahlíková	cahlíková	PROPN
biomedich-396	188	2	,	,	PUNCT
biomedich-396	188	3	l.	l.	PROPN
biomedich-396	188	4	,	,	PUNCT
biomedich-396	188	5	vrabec	vrabec	PROPN
biomedich-396	188	6	,	,	PUNCT
biomedich-396	188	7	r.	r.	PROPN
biomedich-396	188	8	,	,	PUNCT
biomedich-396	188	9	pidaný	pidaný	PROPN
biomedich-396	188	10	,	,	PUNCT
biomedich-396	188	11	f.	f.	PROPN
biomedich-396	188	12	,	,	PUNCT
biomedich-396	188	13	peřinová	peřinová	PROPN
biomedich-396	188	14	,	,	PUNCT
biomedich-396	188	15	r.	r.	PROPN
biomedich-396	188	16	,	,	PUNCT
biomedich-396	188	17	maafi	maafi	PROPN
biomedich-396	188	18	,	,	PUNCT
biomedich-396	188	19	n.	n.	NOUN
biomedich-396	188	20	,	,	PUNCT
biomedich-396	188	21	mamun	mamun	PROPN
biomedich-396	188	22	,	,	PUNCT
biomedich-396	188	23	a.	a.	NOUN
biomedich-396	188	24	a.	a.	PROPN
biomedich-396	188	25	,	,	PUNCT
biomedich-396	188	26	.	.	PUNCT
biomedich-396	188	27	.	.	PUNCT
biomedich-396	188	28	.	.	PUNCT
biomedich-396	189	1	blunden	blunden	PROPN
biomedich-396	189	2	,	,	PUNCT
biomedich-396	189	3	g.	g.	PROPN
biomedich-396	189	4	(	(	PUNCT
biomedich-396	189	5	2021	2021	NUM
biomedich-396	189	6	)	)	PUNCT
biomedich-396	189	7	.	.	PUNCT
biomedich-396	190	1	recent	recent	ADJ
biomedich-396	190	2	progress	progress	NOUN
biomedich-396	190	3	on	on	ADP
biomedich-396	190	4	biological	biological	ADJ
biomedich-396	190	5	activity	activity	NOUN
biomedich-396	190	6	of	of	ADP
biomedich-396	190	7	amaryllidaceae	amaryllidaceae	NOUN
biomedich-396	190	8	and	and	CCONJ
biomedich-396	190	9	further	further	ADJ
biomedich-396	190	10	isoquinoline	isoquinoline	ADJ
biomedich-396	190	11	alkaloids	alkaloid	NOUN
biomedich-396	190	12	in	in	ADP
biomedich-396	190	13	connection	connection	NOUN
biomedich-396	190	14	with	with	ADP
biomedich-396	190	15	alzheimer	alzheimer	PROPN
biomedich-396	190	16	’s	’s	PART
biomedich-396	190	17	disease	disease	NOUN
biomedich-396	190	18	.	.	PUNCT
biomedich-396	191	1	molecules	molecule	NOUN
biomedich-396	191	2	,	,	PUNCT
biomedich-396	191	3	26(17	26(17	NUM
biomedich-396	191	4	)	)	PUNCT
biomedich-396	191	5	,	,	PUNCT
biomedich-396	191	6	5240	5240	NUM
biomedich-396	191	7	.	.	PUNCT
biomedich-396	192	1	charan	charan	PROPN
biomedich-396	192	2	,	,	PUNCT
biomedich-396	192	3	j.	j.	PROPN
biomedich-396	192	4	,	,	PUNCT
biomedich-396	192	5	goyal	goyal	PROPN
biomedich-396	192	6	,	,	PUNCT
biomedich-396	192	7	j.	j.	PROPN
biomedich-396	192	8	p.	p.	PROPN
biomedich-396	192	9	,	,	PUNCT
biomedich-396	192	10	reljic	reljic	NOUN
biomedich-396	192	11	,	,	PUNCT
biomedich-396	192	12	t.	t.	PROPN
biomedich-396	192	13	,	,	PUNCT
biomedich-396	192	14	emmanuel	emmanuel	PROPN
biomedich-396	192	15	,	,	PUNCT
biomedich-396	192	16	p.	p.	PROPN
biomedich-396	192	17	,	,	PUNCT
biomedich-396	192	18	patel	patel	PROPN
biomedich-396	192	19	,	,	PUNCT
biomedich-396	192	20	a.	a.	PROPN
biomedich-396	192	21	,	,	PUNCT
biomedich-396	192	22	&	&	CCONJ
biomedich-396	192	23	kumar	kumar	PROPN
biomedich-396	192	24	,	,	PUNCT
biomedich-396	192	25	a.	a.	NOUN
biomedich-396	192	26	(	(	PUNCT
biomedich-396	192	27	2018	2018	NUM
biomedich-396	192	28	)	)	PUNCT
biomedich-396	192	29	.	.	PUNCT
biomedich-396	193	1	isoniazid	isoniazid	PROPN
biomedich-396	193	2	for	for	ADP
biomedich-396	193	3	the	the	DET
biomedich-396	193	4	prevention	prevention	NOUN
biomedich-396	193	5	of	of	ADP
biomedich-396	193	6	tuberculosis	tuberculosis	NOUN
biomedich-396	193	7	in	in	ADP
biomedich-396	193	8	hiv	hiv	PROPN
biomedich-396	193	9	-	-	PUNCT
biomedich-396	193	10	infected	infect	VERB
biomedich-396	193	11	children	child	NOUN
biomedich-396	193	12	:	:	PUNCT
biomedich-396	193	13	a	a	DET
biomedich-396	193	14	systematic	systematic	ADJ
biomedich-396	193	15	review	review	NOUN
biomedich-396	193	16	and	and	CCONJ
biomedich-396	193	17	metaanalysis	metaanalysis	NOUN
biomedich-396	193	18	.	.	PUNCT
biomedich-396	194	1	pediatr	pediatr	PROPN
biomedich-396	194	2	infect	infect	VERB
biomedich-396	194	3	dis	dis	PROPN
biomedich-396	194	4	j	j	PROPN
biomedich-396	194	5	,	,	PUNCT
biomedich-396	194	6	37(8	37(8	NUM
biomedich-396	194	7	)	)	PUNCT
biomedich-396	194	8	,	,	PUNCT
biomedich-396	194	9	773	773	NUM
biomedich-396	194	10	-	-	SYM
biomedich-396	194	11	780	780	NUM
biomedich-396	194	12	.	.	PUNCT
biomedich-396	195	1	doi	doi	NOUN
biomedich-396	195	2	:	:	PUNCT
biomedich-396	195	3	10.1097	10.1097	NUM
biomedich-396	195	4	/	/	SYM
biomedich-396	195	5	inf.0000000000001879	inf.0000000000001879	X
biomedich-396	195	6	dallakyan	dallakyan	ADJ
biomedich-396	195	7	,	,	PUNCT
biomedich-396	195	8	s.	s.	PROPN
biomedich-396	195	9	,	,	PUNCT
biomedich-396	195	10	&	&	CCONJ
biomedich-396	195	11	olson	olson	PROPN
biomedich-396	195	12	,	,	PUNCT
biomedich-396	195	13	a.	a.	PROPN
biomedich-396	195	14	j.	j.	PROPN
biomedich-396	195	15	(	(	PUNCT
biomedich-396	195	16	2015	2015	NUM
biomedich-396	195	17	)	)	PUNCT
biomedich-396	195	18	.	.	PUNCT
biomedich-396	196	1	small	small	ADJ
biomedich-396	196	2	-	-	PUNCT
biomedich-396	196	3	molecule	molecule	NOUN
biomedich-396	196	4	library	library	NOUN
biomedich-396	196	5	screening	screening	NOUN
biomedich-396	196	6	by	by	ADP
biomedich-396	196	7	docking	dock	VERB
biomedich-396	196	8	with	with	ADP
biomedich-396	196	9	pyrx	pyrx	NOUN
biomedich-396	196	10	.	.	PUNCT
biomedich-396	197	1	chemical	chemical	NOUN
biomedich-396	197	2	biology	biology	NOUN
biomedich-396	197	3	:	:	PUNCT
biomedich-396	197	4	methods	method	NOUN
biomedich-396	197	5	and	and	CCONJ
biomedich-396	197	6	protocols	protocol	NOUN
biomedich-396	197	7	,	,	PUNCT
biomedich-396	197	8	243	243	NUM
biomedich-396	197	9	-	-	SYM
biomedich-396	197	10	250	250	NUM
biomedich-396	197	11	.	.	PUNCT
biomedich-396	198	1	druszczyńska	druszczyńska	PROPN
biomedich-396	198	2	,	,	PUNCT
biomedich-396	198	3	m.	m.	NOUN
biomedich-396	198	4	,	,	PUNCT
biomedich-396	198	5	kowalewicz	kowalewicz	PROPN
biomedich-396	198	6	-	-	PUNCT
biomedich-396	198	7	kulbat	kulbat	PROPN
biomedich-396	198	8	,	,	PUNCT
biomedich-396	198	9	m.	m.	NOUN
biomedich-396	198	10	,	,	PUNCT
biomedich-396	198	11	fol	fol	NOUN
biomedich-396	198	12	,	,	PUNCT
biomedich-396	198	13	m.	m.	NOUN
biomedich-396	198	14	,	,	PUNCT
biomedich-396	198	15	włodarczyk	włodarczyk	INTJ
biomedich-396	198	16	,	,	PUNCT
biomedich-396	198	17	m.	m.	NOUN
biomedich-396	198	18	,	,	PUNCT
biomedich-396	198	19	&	&	CCONJ
biomedich-396	198	20	rudnicka	rudnicka	PROPN
biomedich-396	198	21	,	,	PUNCT
biomedich-396	198	22	w.	w.	PROPN
biomedich-396	198	23	(	(	PUNCT
biomedich-396	198	24	2012	2012	NUM
biomedich-396	198	25	)	)	PUNCT
biomedich-396	198	26	.	.	PUNCT
biomedich-396	199	1	latent	latent	NOUN
biomedich-396	199	2	m.	m.	NOUN
biomedich-396	199	3	tuberculosis	tuberculosis	ADP
biomedich-396	199	4	infection	infection	NOUN
biomedich-396	199	5	-	-	PUNCT
biomedich-396	199	6	pathogenesis	pathogenesis	NOUN
biomedich-396	199	7	,	,	PUNCT
biomedich-396	199	8	diagnosis	diagnosis	NOUN
biomedich-396	199	9	,	,	PUNCT
biomedich-396	199	10	treatment	treatment	NOUN
biomedich-396	199	11	and	and	CCONJ
biomedich-396	199	12	prevention	prevention	NOUN
biomedich-396	199	13	strategies	strategy	NOUN
biomedich-396	199	14	.	.	PUNCT
biomedich-396	200	1	pol	pol	PROPN
biomedich-396	200	2	j	j	PROPN
biomedich-396	200	3	microbiol	microbiol	PROPN
biomedich-396	200	4	,	,	PUNCT
biomedich-396	200	5	61(1	61(1	NOUN
biomedich-396	200	6	)	)	PUNCT
biomedich-396	200	7	,	,	PUNCT
biomedich-396	200	8	3	3	NUM
biomedich-396	200	9	-	-	SYM
biomedich-396	200	10	10	10	NUM
biomedich-396	200	11	.	.	PUNCT
biomedich-396	201	1	fan	fan	PROPN
biomedich-396	201	2	,	,	PUNCT
biomedich-396	201	3	j.	j.	PROPN
biomedich-396	201	4	,	,	PUNCT
biomedich-396	201	5	fu	fu	PROPN
biomedich-396	201	6	,	,	PUNCT
biomedich-396	201	7	a.	a.	PROPN
biomedich-396	201	8	,	,	PUNCT
biomedich-396	201	9	&	&	CCONJ
biomedich-396	201	10	zhang	zhang	PROPN
biomedich-396	201	11	,	,	PUNCT
biomedich-396	201	12	l.	l.	PROPN
biomedich-396	201	13	(	(	PUNCT
biomedich-396	201	14	2019	2019	NUM
biomedich-396	201	15	)	)	PUNCT
biomedich-396	201	16	.	.	PUNCT
biomedich-396	202	1	progress	progress	NOUN
biomedich-396	202	2	in	in	ADP
biomedich-396	202	3	molecular	molecular	ADJ
biomedich-396	202	4	docking	docking	NOUN
biomedich-396	202	5	.	.	PUNCT
biomedich-396	203	1	quantitative	quantitative	ADJ
biomedich-396	203	2	biology	biology	NOUN
biomedich-396	203	3	,	,	PUNCT
biomedich-396	203	4	7(2	7(2	NUM
biomedich-396	203	5	)	)	PUNCT
biomedich-396	203	6	,	,	PUNCT
biomedich-396	203	7	83	83	NUM
biomedich-396	203	8	-	-	SYM
biomedich-396	203	9	89	89	NUM
biomedich-396	203	10	.	.	PUNCT
biomedich-396	204	1	doi	doi	NOUN
biomedich-396	204	2	:	:	PUNCT
biomedich-396	204	3	10.1007	10.1007	NUM
biomedich-396	204	4	/	/	SYM
biomedich-396	204	5	s40484	s40484	NOUN
biomedich-396	204	6	-	-	PUNCT
biomedich-396	204	7	019	019	NUM
biomedich-396	204	8	-	-	PUNCT
biomedich-396	204	9	0172	0172	NUM
biomedich-396	204	10	-	-	PUNCT
biomedich-396	204	11	y	y	NOUN
biomedich-396	204	12	gong	gong	NOUN
biomedich-396	204	13	,	,	PUNCT
biomedich-396	204	14	y.	y.	PROPN
biomedich-396	204	15	,	,	PUNCT
biomedich-396	204	16	li	li	PROPN
biomedich-396	204	17	,	,	PUNCT
biomedich-396	204	18	s.	s.	PROPN
biomedich-396	204	19	,	,	PUNCT
biomedich-396	204	20	wang	wang	PROPN
biomedich-396	204	21	,	,	PUNCT
biomedich-396	204	22	w.	w.	PROPN
biomedich-396	204	23	,	,	PUNCT
biomedich-396	204	24	li	li	PROPN
biomedich-396	204	25	,	,	PUNCT
biomedich-396	204	26	y.	y.	PROPN
biomedich-396	204	27	,	,	PUNCT
biomedich-396	204	28	ma	ma	PROPN
biomedich-396	204	29	,	,	PUNCT
biomedich-396	204	30	w.	w.	PROPN
biomedich-396	204	31	,	,	PUNCT
biomedich-396	204	32	&	&	CCONJ
biomedich-396	204	33	sun	sun	PROPN
biomedich-396	204	34	,	,	PUNCT
biomedich-396	204	35	s.	s.	PROPN
biomedich-396	204	36	(	(	PUNCT
biomedich-396	204	37	2019	2019	NUM
biomedich-396	204	38	)	)	PUNCT
biomedich-396	204	39	.	.	PUNCT
biomedich-396	205	1	in	in	ADP
biomedich-396	205	2	vitro	vitro	X
biomedich-396	205	3	and	and	CCONJ
biomedich-396	205	4	in	in	ADP
biomedich-396	205	5	vivo	vivo	ADJ
biomedich-396	205	6	activity	activity	NOUN
biomedich-396	205	7	of	of	ADP
biomedich-396	205	8	chelerythrine	chelerythrine	NOUN
biomedich-396	205	9	against	against	ADP
biomedich-396	205	10	candida	candida	NOUN
biomedich-396	205	11	albicans	albican	NOUN
biomedich-396	205	12	and	and	CCONJ
biomedich-396	205	13	underlying	underlying	ADJ
biomedich-396	205	14	mechanisms	mechanism	NOUN
biomedich-396	205	15	.	.	PUNCT
biomedich-396	206	1	future	future	ADJ
biomedich-396	206	2	microbiology	microbiology	NOUN
biomedich-396	206	3	,	,	PUNCT
biomedich-396	206	4	14(18	14(18	NOUN
biomedich-396	206	5	)	)	PUNCT
biomedich-396	206	6	,	,	PUNCT
biomedich-396	206	7	1545	1545	NUM
biomedich-396	206	8	-	-	SYM
biomedich-396	206	9	1557	1557	NUM
biomedich-396	206	10	.	.	PUNCT
biomedich-396	207	1	grabarska	grabarska	PROPN
biomedich-396	207	2	,	,	PUNCT
biomedich-396	207	3	a.	a.	NOUN
biomedich-396	207	4	,	,	PUNCT
biomedich-396	207	5	wróblewska	wróblewska	NOUN
biomedich-396	207	6	-	-	PUNCT
biomedich-396	207	7	łuczka	łuczka	NOUN
biomedich-396	207	8	,	,	PUNCT
biomedich-396	207	9	p.	p.	NOUN
biomedich-396	207	10	,	,	PUNCT
biomedich-396	207	11	kukula	kukula	PROPN
biomedich-396	207	12	-	-	PUNCT
biomedich-396	207	13	koch	koch	PROPN
biomedich-396	207	14	,	,	PUNCT
biomedich-396	207	15	w.	w.	PROPN
biomedich-396	207	16	,	,	PUNCT
biomedich-396	207	17	łuszczki	łuszczki	PROPN
biomedich-396	207	18	,	,	PUNCT
biomedich-396	207	19	j.	j.	PROPN
biomedich-396	207	20	j.	j.	PROPN
biomedich-396	207	21	,	,	PUNCT
biomedich-396	207	22	kalpoutzakis	kalpoutzakis	PROPN
biomedich-396	207	23	,	,	PUNCT
biomedich-396	207	24	e.	e.	PROPN
biomedich-396	207	25	,	,	PUNCT
biomedich-396	207	26	adamczuk	adamczuk	PROPN
biomedich-396	207	27	,	,	PUNCT
biomedich-396	207	28	g.	g.	PROPN
biomedich-396	207	29	,	,	PUNCT
biomedich-396	207	30	.	.	PUNCT
biomedich-396	207	31	.	.	PUNCT
biomedich-396	207	32	.	.	PUNCT
biomedich-396	208	1	stepulak	stepulak	NOUN
biomedich-396	208	2	,	,	PUNCT
biomedich-396	208	3	a.	a.	NOUN
biomedich-396	208	4	(	(	PUNCT
biomedich-396	208	5	2021	2021	NUM
biomedich-396	208	6	)	)	PUNCT
biomedich-396	208	7	.	.	PUNCT
biomedich-396	209	1	palmatine	palmatine	PROPN
biomedich-396	209	2	,	,	PUNCT
biomedich-396	209	3	a	a	DET
biomedich-396	209	4	bioactive	bioactive	NOUN
biomedich-396	209	5	protoberberine	protoberberine	NOUN
biomedich-396	209	6	alkaloid	alkaloid	NOUN
biomedich-396	209	7	isolated	isolate	VERB
biomedich-396	209	8	from	from	ADP
biomedich-396	209	9	berberis	berberis	PROPN
biomedich-396	209	10	cretica	cretica	PROPN
biomedich-396	209	11	,	,	PUNCT
biomedich-396	209	12	inhibits	inhibit	VERB
biomedich-396	209	13	the	the	DET
biomedich-396	209	14	growth	growth	NOUN
biomedich-396	209	15	of	of	ADP
biomedich-396	209	16	human	human	ADJ
biomedich-396	209	17	estrogen	estrogen	NOUN
biomedich-396	209	18	receptor	receptor	NOUN
biomedich-396	209	19	-	-	PUNCT
biomedich-396	209	20	positive	positive	ADJ
biomedich-396	209	21	breast	breast	NOUN
biomedich-396	209	22	cancer	cancer	NOUN
biomedich-396	209	23	cells	cell	NOUN
biomedich-396	209	24	and	and	CCONJ
biomedich-396	209	25	acts	act	VERB
biomedich-396	209	26	synergistically	synergistically	ADV
biomedich-396	209	27	and	and	CCONJ
biomedich-396	209	28	additively	additively	ADV
biomedich-396	209	29	with	with	ADP
biomedich-396	209	30	doxorubicin	doxorubicin	PROPN
biomedich-396	209	31	.	.	PUNCT
biomedich-396	210	1	molecules	molecule	NOUN
biomedich-396	210	2	,	,	PUNCT
biomedich-396	210	3	26(20	26(20	NOUN
biomedich-396	210	4	)	)	PUNCT
biomedich-396	210	5	,	,	PUNCT
biomedich-396	210	6	6253	6253	NUM
biomedich-396	210	7	.	.	PUNCT
biomedich-396	211	1	huang	huang	PROPN
biomedich-396	211	2	,	,	PUNCT
biomedich-396	211	3	s.-f	s.-f	PROPN
biomedich-396	211	4	.	.	PUNCT
biomedich-396	211	5	,	,	PUNCT
biomedich-396	211	6	chen	chen	PROPN
biomedich-396	211	7	,	,	PUNCT
biomedich-396	211	8	m.-h	m.-h	PROPN
biomedich-396	211	9	.	.	PROPN
biomedich-396	211	10	,	,	PUNCT
biomedich-396	211	11	wang	wang	PROPN
biomedich-396	211	12	,	,	PUNCT
biomedich-396	211	13	f.-d	f.-d	PROPN
biomedich-396	211	14	.	.	PUNCT
biomedich-396	211	15	,	,	PUNCT
biomedich-396	211	16	tsai	tsai	PROPN
biomedich-396	211	17	,	,	PUNCT
biomedich-396	211	18	c.-y	c.-y	NOUN
biomedich-396	211	19	.	.	PUNCT
biomedich-396	211	20	,	,	PUNCT
biomedich-396	211	21	fung	fung	PROPN
biomedich-396	211	22	,	,	PUNCT
biomedich-396	211	23	c.-p	c.-p	PROPN
biomedich-396	211	24	.	.	PROPN
biomedich-396	211	25	,	,	PUNCT
biomedich-396	211	26	&	&	CCONJ
biomedich-396	211	27	su	su	PROPN
biomedich-396	211	28	,	,	PUNCT
biomedich-396	211	29	w.-j	w.-j	PROPN
biomedich-396	211	30	.	.	PUNCT
biomedich-396	212	1	(	(	PUNCT
biomedich-396	212	2	2018	2018	NUM
biomedich-396	212	3	)	)	PUNCT
biomedich-396	212	4	.	.	PUNCT
biomedich-396	213	1	efficacy	efficacy	NOUN
biomedich-396	213	2	of	of	ADP
biomedich-396	213	3	isoniazid	isoniazid	NOUN
biomedich-396	213	4	salvage	salvage	NOUN
biomedich-396	213	5	therapy	therapy	NOUN
biomedich-396	213	6	for	for	ADP
biomedich-396	213	7	latent	latent	NOUN
biomedich-396	213	8	tuberculosis	tuberculosis	NOUN
biomedich-396	213	9	infection	infection	NOUN
biomedich-396	213	10	in	in	ADP
biomedich-396	213	11	patients	patient	NOUN
biomedich-396	213	12	with	with	ADP
biomedich-396	213	13	immune	immune	NOUN
biomedich-396	213	14	-	-	PUNCT
biomedich-396	213	15	mediated	mediate	VERB
biomedich-396	213	16	inflammatory	inflammatory	ADJ
biomedich-396	213	17	disorders	disorder	NOUN
biomedich-396	213	18	–	–	PUNCT
biomedich-396	213	19	a	a	DET
biomedich-396	213	20	retrospective	retrospective	ADJ
biomedich-396	213	21	cohort	cohort	NOUN
biomedich-396	213	22	study	study	NOUN
biomedich-396	213	23	in	in	ADP
biomedich-396	213	24	taiwan	taiwan	PROPN
biomedich-396	213	25	.	.	PUNCT
biomedich-396	214	1	journal	journal	PROPN
biomedich-396	214	2	of	of	ADP
biomedich-396	214	3	microbiology	microbiology	NOUN
biomedich-396	214	4	,	,	PUNCT
biomedich-396	214	5	immunology	immunology	NOUN
biomedich-396	214	6	and	and	CCONJ
biomedich-396	214	7	infection	infection	NOUN
biomedich-396	214	8	,	,	PUNCT
biomedich-396	214	9	51(6	51(6	NOUN
biomedich-396	214	10	)	)	PUNCT
biomedich-396	214	11	,	,	PUNCT
biomedich-396	214	12	784	784	NUM
biomedich-396	214	13	-	-	SYM
biomedich-396	214	14	793	793	NUM
biomedich-396	214	15	.	.	PUNCT
biomedich-396	215	1	kuzmanic	kuzmanic	PROPN
biomedich-396	215	2	,	,	PUNCT
biomedich-396	215	3	a.	a.	PROPN
biomedich-396	215	4	,	,	PUNCT
biomedich-396	215	5	bowman	bowman	PROPN
biomedich-396	215	6	,	,	PUNCT
biomedich-396	215	7	g.	g.	PROPN
biomedich-396	215	8	r.	r.	PROPN
biomedich-396	215	9	,	,	PUNCT
biomedich-396	215	10	juarez	juarez	PROPN
biomedich-396	215	11	-	-	PUNCT
biomedich-396	215	12	jimenez	jimenez	PROPN
biomedich-396	215	13	,	,	PUNCT
biomedich-396	215	14	j.	j.	PROPN
biomedich-396	215	15	,	,	PUNCT
biomedich-396	215	16	michel	michel	PROPN
biomedich-396	215	17	,	,	PUNCT
biomedich-396	215	18	j.	j.	PROPN
biomedich-396	215	19	,	,	PUNCT
biomedich-396	215	20	&	&	CCONJ
biomedich-396	215	21	gervasio	gervasio	PROPN
biomedich-396	215	22	,	,	PUNCT
biomedich-396	215	23	f.	f.	PROPN
biomedich-396	215	24	l.	l.	PROPN
biomedich-396	215	25	(	(	PUNCT
biomedich-396	215	26	2020	2020	NUM
biomedich-396	215	27	)	)	PUNCT
biomedich-396	215	28	.	.	PUNCT
biomedich-396	216	1	investigating	investigate	VERB
biomedich-396	216	2	cryptic	cryptic	ADJ
biomedich-396	216	3	binding	bind	VERB
biomedich-396	216	4	sites	site	NOUN
biomedich-396	216	5	by	by	ADP
biomedich-396	216	6	molecular	molecular	ADJ
biomedich-396	216	7	dynamics	dynamic	NOUN
biomedich-396	216	8	simulations	simulation	NOUN
biomedich-396	216	9	.	.	PUNCT
biomedich-396	217	1	accounts	account	NOUN
biomedich-396	217	2	of	of	ADP
biomedich-396	217	3	chemical	chemical	NOUN
biomedich-396	217	4	research	research	NOUN
biomedich-396	217	5	,	,	PUNCT
biomedich-396	217	6	53(3	53(3	NUM
biomedich-396	217	7	)	)	PUNCT
biomedich-396	217	8	,	,	PUNCT
biomedich-396	217	9	654	654	NUM
biomedich-396	217	10	-	-	SYM
biomedich-396	217	11	661	661	NUM
biomedich-396	217	12	.	.	PUNCT
biomedich-396	218	1	lamb	lamb	PROPN
biomedich-396	218	2	,	,	PUNCT
biomedich-396	218	3	c.	c.	PROPN
biomedich-396	218	4	,	,	PUNCT
biomedich-396	218	5	&	&	CCONJ
biomedich-396	218	6	mauermann	mauermann	PROPN
biomedich-396	218	7	,	,	PUNCT
biomedich-396	218	8	m.	m.	NOUN
biomedich-396	218	9	(	(	PUNCT
biomedich-396	218	10	2021	2021	NUM
biomedich-396	218	11	)	)	PUNCT
biomedich-396	218	12	.	.	PUNCT
biomedich-396	219	1	isoniazid	isoniazid	NOUN
biomedich-396	219	2	-	-	PUNCT
biomedich-396	219	3	associated	associate	VERB
biomedich-396	219	4	peripheral	peripheral	ADJ
biomedich-396	219	5	neuropathy	neuropathy	ADJ
biomedich-396	219	6	in	in	ADP
biomedich-396	219	7	a	a	DET
biomedich-396	219	8	“	"	PUNCT
biomedich-396	219	9	slow	slow	ADJ
biomedich-396	219	10	acetylator	acetylator	NOUN
biomedich-396	219	11	”	"	PUNCT
biomedich-396	219	12	:	:	PUNCT
biomedich-396	219	13	need	need	VERB
biomedich-396	219	14	for	for	ADP
biomedich-396	219	15	pharmacogenomics	pharmacogenomic	NOUN
biomedich-396	219	16	in	in	ADP
biomedich-396	219	17	tuberculosis	tuberculosis	NOUN
biomedich-396	219	18	treatment?(4253	treatment?(4253	ADJ
biomedich-396	219	19	):	):	PUNCT
biomedich-396	219	20	aan	aan	PROPN
biomedich-396	219	21	enterprises	enterprise	NOUN
biomedich-396	219	22	.	.	PUNCT
biomedich-396	220	1	lin	lin	PROPN
biomedich-396	220	2	,	,	PUNCT
biomedich-396	220	3	w.	w.	PROPN
biomedich-396	220	4	,	,	PUNCT
biomedich-396	220	5	huang	huang	PROPN
biomedich-396	220	6	,	,	PUNCT
biomedich-396	220	7	j.	j.	PROPN
biomedich-396	220	8	,	,	PUNCT
biomedich-396	220	9	yuan	yuan	PROPN
biomedich-396	220	10	,	,	PUNCT
biomedich-396	220	11	z.	z.	PROPN
biomedich-396	220	12	,	,	PUNCT
biomedich-396	220	13	feng	feng	PROPN
biomedich-396	220	14	,	,	PUNCT
biomedich-396	220	15	s.	s.	PROPN
biomedich-396	220	16	,	,	PUNCT
biomedich-396	220	17	xie	xie	PROPN
biomedich-396	220	18	,	,	PUNCT
biomedich-396	220	19	y.	y.	PROPN
biomedich-396	220	20	,	,	PUNCT
biomedich-396	220	21	&	&	CCONJ
biomedich-396	220	22	ma	ma	PROPN
biomedich-396	220	23	,	,	PUNCT
biomedich-396	220	24	w.	w.	PROPN
biomedich-396	220	25	(	(	PUNCT
biomedich-396	220	26	2017	2017	NUM
biomedich-396	220	27	)	)	PUNCT
biomedich-396	220	28	.	.	PUNCT
biomedich-396	221	1	protein	protein	NOUN
biomedich-396	221	2	kinase	kinase	PROPN
biomedich-396	221	3	c	c	PROPN
biomedich-396	221	4	inhibitor	inhibitor	NOUN
biomedich-396	221	5	chelerythrine	chelerythrine	NOUN
biomedich-396	221	6	selectively	selectively	ADV
biomedich-396	221	7	inhibits	inhibit	VERB
biomedich-396	221	8	proliferation	proliferation	NOUN
biomedich-396	221	9	of	of	ADP
biomedich-396	221	10	triple	triple	ADJ
biomedich-396	221	11	-	-	PUNCT
biomedich-396	221	12	negative	negative	ADJ
biomedich-396	221	13	breast	breast	NOUN
biomedich-396	221	14	cancer	cancer	NOUN
biomedich-396	221	15	cells	cell	NOUN
biomedich-396	221	16	.	.	PUNCT
biomedich-396	222	1	scientific	scientific	ADJ
biomedich-396	222	2	reports	report	NOUN
biomedich-396	222	3	,	,	PUNCT
biomedich-396	222	4	7(1	7(1	NUM
biomedich-396	222	5	)	)	PUNCT
biomedich-396	222	6	,	,	PUNCT
biomedich-396	222	7	1	1	NUM
biomedich-396	222	8	-	-	SYM
biomedich-396	222	9	12	12	NUM
biomedich-396	222	10	.	.	PUNCT
biomedich-396	223	1	lópez	lópez	NOUN
biomedich-396	223	2	-	-	PUNCT
biomedich-396	223	3	blanco	blanco	PROPN
biomedich-396	223	4	,	,	PUNCT
biomedich-396	223	5	j.	j.	PROPN
biomedich-396	223	6	r.	r.	PROPN
biomedich-396	223	7	,	,	PUNCT
biomedich-396	223	8	aliaga	aliaga	PROPN
biomedich-396	223	9	,	,	PUNCT
biomedich-396	223	10	j.	j.	PROPN
biomedich-396	223	11	i.	i.	PROPN
biomedich-396	223	12	,	,	PUNCT
biomedich-396	223	13	quintana	quintana	PROPN
biomedich-396	223	14	-	-	PUNCT
biomedich-396	223	15	ortí	ortí	NOUN
biomedich-396	223	16	,	,	PUNCT
biomedich-396	223	17	e.	e.	PROPN
biomedich-396	223	18	s.	s.	PROPN
biomedich-396	223	19	,	,	PUNCT
biomedich-396	223	20	&	&	CCONJ
biomedich-396	223	21	chacón	chacón	PROPN
biomedich-396	223	22	,	,	PUNCT
biomedich-396	223	23	p.	p.	NOUN
biomedich-396	223	24	(	(	PUNCT
biomedich-396	223	25	2014	2014	NUM
biomedich-396	223	26	)	)	PUNCT
biomedich-396	223	27	.	.	PUNCT
biomedich-396	224	1	imods	imod	NOUN
biomedich-396	224	2	:	:	PUNCT
biomedich-396	224	3	internal	internal	ADJ
biomedich-396	224	4	coordinates	coordinate	NOUN
biomedich-396	224	5	normal	normal	ADJ
biomedich-396	224	6	mode	mode	NOUN
biomedich-396	224	7	analysis	analysis	NOUN
biomedich-396	224	8	server	server	NOUN
biomedich-396	224	9	.	.	PUNCT
biomedich-396	225	1	nucleic	nucleic	ADJ
biomedich-396	225	2	acids	acid	NOUN
biomedich-396	225	3	res	re	NOUN
biomedich-396	225	4	,	,	PUNCT
biomedich-396	225	5	42(web	42(web	NOUN
biomedich-396	225	6	server	server	NOUN
biomedich-396	225	7	issue	issue	NOUN
biomedich-396	225	8	)	)	PUNCT
biomedich-396	225	9	,	,	PUNCT
biomedich-396	225	10	w271	w271	PROPN
biomedich-396	225	11	-	-	PUNCT
biomedich-396	225	12	276	276	NUM
biomedich-396	225	13	.	.	PUNCT
biomedich-396	226	1	doi	doi	NOUN
biomedich-396	226	2	:	:	PUNCT
biomedich-396	226	3	10.1093	10.1093	NUM
biomedich-396	226	4	/	/	SYM
biomedich-396	226	5	nar	nar	NOUN
biomedich-396	226	6	/	/	SYM
biomedich-396	226	7	gku339	gku339	NOUN
biomedich-396	226	8	lopéz	lopéz	NOUN
biomedich-396	226	9	-	-	PUNCT
biomedich-396	226	10	blanco	blanco	PROPN
biomedich-396	226	11	,	,	PUNCT
biomedich-396	226	12	j.	j.	PROPN
biomedich-396	226	13	r.	r.	PROPN
biomedich-396	226	14	,	,	PUNCT
biomedich-396	226	15	garzón	garzón	PROPN
biomedich-396	226	16	,	,	PUNCT
biomedich-396	226	17	j.	j.	PROPN
biomedich-396	226	18	i.	i.	PROPN
biomedich-396	226	19	,	,	PUNCT
biomedich-396	226	20	&	&	CCONJ
biomedich-396	226	21	chacón	chacón	PROPN
biomedich-396	226	22	,	,	PUNCT
biomedich-396	226	23	p.	p.	NOUN
biomedich-396	226	24	(	(	PUNCT
biomedich-396	226	25	2011	2011	NUM
biomedich-396	226	26	)	)	PUNCT
biomedich-396	226	27	.	.	PUNCT
biomedich-396	227	1	imod	imod	PROPN
biomedich-396	227	2	:	:	PUNCT
biomedich-396	227	3	multipurpose	multipurpose	VERB
biomedich-396	227	4	normal	normal	ADJ
biomedich-396	227	5	mode	mode	NOUN
biomedich-396	227	6	analysis	analysis	NOUN
biomedich-396	227	7	in	in	ADP
biomedich-396	227	8	internal	internal	ADJ
biomedich-396	227	9	coordinates	coordinate	NOUN
biomedich-396	227	10	.	.	PUNCT
biomedich-396	228	1	bioinformatics	bioinformatic	NOUN
biomedich-396	228	2	,	,	PUNCT
biomedich-396	228	3	27(20	27(20	NUM
biomedich-396	228	4	)	)	PUNCT
biomedich-396	228	5	,	,	PUNCT
biomedich-396	228	6	2843	2843	NUM
biomedich-396	228	7	-	-	SYM
biomedich-396	228	8	2850	2850	NUM
biomedich-396	228	9	.	.	PUNCT
biomedich-396	229	1	doi	doi	NOUN
biomedich-396	229	2	:	:	PUNCT
biomedich-396	229	3	10.1093	10.1093	NUM
biomedich-396	229	4	/	/	SYM
biomedich-396	229	5	bioinformatics	bioinformatics	NOUN
biomedich-396	229	6	/	/	SYM
biomedich-396	229	7	btr497	btr497	NOUN
biomedich-396	229	8	mafukidze	mafukidze	NOUN
biomedich-396	229	9	,	,	PUNCT
biomedich-396	229	10	a.	a.	NOUN
biomedich-396	229	11	t.	t.	PROPN
biomedich-396	229	12	,	,	PUNCT
biomedich-396	229	13	calnan	calnan	NOUN
biomedich-396	229	14	,	,	PUNCT
biomedich-396	229	15	m.	m.	NOUN
biomedich-396	229	16	,	,	PUNCT
biomedich-396	229	17	&	&	CCONJ
biomedich-396	229	18	furin	furin	NOUN
biomedich-396	229	19	,	,	PUNCT
biomedich-396	229	20	j.	j.	PROPN
biomedich-396	229	21	(	(	PUNCT
biomedich-396	229	22	2016	2016	NUM
biomedich-396	229	23	)	)	PUNCT
biomedich-396	229	24	.	.	PUNCT
biomedich-396	230	1	peripheral	peripheral	ADJ
biomedich-396	230	2	neuropathy	neuropathy	ADJ
biomedich-396	230	3	in	in	ADP
biomedich-396	230	4	persons	person	NOUN
biomedich-396	230	5	with	with	ADP
biomedich-396	230	6	tuberculosis	tuberculosis	NOUN
biomedich-396	230	7	.	.	PUNCT
biomedich-396	231	1	journal	journal	NOUN
biomedich-396	231	2	of	of	ADP
biomedich-396	231	3	clinical	clinical	ADJ
biomedich-396	231	4	tuberculosis	tuberculosis	NOUN
biomedich-396	231	5	and	and	CCONJ
biomedich-396	231	6	other	other	ADJ
biomedich-396	231	7	mycobacterial	mycobacterial	ADJ
biomedich-396	231	8	diseases	disease	NOUN
biomedich-396	231	9	,	,	PUNCT
biomedich-396	231	10	2	2	NUM
biomedich-396	231	11	,	,	PUNCT
biomedich-396	231	12	5	5	NUM
biomedich-396	231	13	-	-	SYM
biomedich-396	231	14	11	11	NUM
biomedich-396	231	15	.	.	PUNCT
biomedich-396	232	1	pease	pease	PROPN
biomedich-396	232	2	,	,	PUNCT
biomedich-396	232	3	c.	c.	PROPN
biomedich-396	232	4	,	,	PUNCT
biomedich-396	232	5	hutton	hutton	PROPN
biomedich-396	232	6	,	,	PUNCT
biomedich-396	232	7	b.	b.	PROPN
biomedich-396	232	8	,	,	PUNCT
biomedich-396	232	9	yazdi	yazdi	PROPN
biomedich-396	232	10	,	,	PUNCT
biomedich-396	232	11	f.	f.	PROPN
biomedich-396	232	12	,	,	PUNCT
biomedich-396	232	13	wolfe	wolfe	PROPN
biomedich-396	232	14	,	,	PUNCT
biomedich-396	232	15	d.	d.	PROPN
biomedich-396	232	16	,	,	PUNCT
biomedich-396	232	17	hamel	hamel	PROPN
biomedich-396	232	18	,	,	PUNCT
biomedich-396	232	19	c.	c.	PROPN
biomedich-396	232	20	,	,	PUNCT
biomedich-396	232	21	quach	quach	NOUN
biomedich-396	232	22	,	,	PUNCT
biomedich-396	232	23	p.	p.	NOUN
biomedich-396	232	24	,	,	PUNCT
biomedich-396	232	25	.	.	PUNCT
biomedich-396	232	26	.	.	PUNCT
biomedich-396	232	27	.	.	PUNCT
biomedich-396	233	1	alvarez	alvarez	PROPN
biomedich-396	233	2	,	,	PUNCT
biomedich-396	233	3	g.	g.	PROPN
biomedich-396	233	4	g.	g.	PROPN
biomedich-396	233	5	(	(	PUNCT
biomedich-396	233	6	2017	2017	NUM
biomedich-396	233	7	)	)	PUNCT
biomedich-396	233	8	.	.	PUNCT
biomedich-396	234	1	efficacy	efficacy	NOUN
biomedich-396	234	2	and	and	CCONJ
biomedich-396	234	3	completion	completion	NOUN
biomedich-396	234	4	rates	rate	NOUN
biomedich-396	234	5	of	of	ADP
biomedich-396	234	6	rifapentine	rifapentine	NOUN
biomedich-396	234	7	and	and	CCONJ
biomedich-396	234	8	isoniazid	isoniazid	NOUN
biomedich-396	234	9	(	(	PUNCT
biomedich-396	234	10	3hp	3hp	NOUN
biomedich-396	234	11	)	)	PUNCT
biomedich-396	234	12	compared	compare	VERB
biomedich-396	234	13	to	to	ADP
biomedich-396	234	14	other	other	ADJ
biomedich-396	234	15	treatment	treatment	NOUN
biomedich-396	234	16	regimens	regimen	NOUN
biomedich-396	234	17	for	for	ADP
biomedich-396	234	18	latent	latent	NOUN
biomedich-396	234	19	tuberculosis	tuberculosis	NOUN
biomedich-396	234	20	infection	infection	NOUN
biomedich-396	234	21	:	:	PUNCT
biomedich-396	234	22	a	a	DET
biomedich-396	234	23	systematic	systematic	ADJ
biomedich-396	234	24	review	review	NOUN
biomedich-396	234	25	with	with	ADP
biomedich-396	234	26	network	network	NOUN
biomedich-396	234	27	meta	meta	X
biomedich-396	234	28	-	-	PUNCT
biomedich-396	234	29	analyses	analysis	NOUN
biomedich-396	234	30	.	.	PUNCT
biomedich-396	235	1	bmc	bmc	ADJ
biomedich-396	235	2	infectious	infectious	ADJ
biomedich-396	235	3	diseases	disease	NOUN
biomedich-396	235	4	,	,	PUNCT
biomedich-396	235	5	17(1	17(1	NUM
biomedich-396	235	6	)	)	PUNCT
biomedich-396	235	7	,	,	PUNCT
biomedich-396	235	8	265	265	NUM
biomedich-396	235	9	.	.	PUNCT
biomedich-396	236	1	doi	doi	NOUN
biomedich-396	236	2	:	:	PUNCT
biomedich-396	236	3	10.1186	10.1186	NUM
biomedich-396	236	4	/	/	SYM
biomedich-396	236	5	s12879	s12879	ADJ
biomedich-396	236	6	-	-	PUNCT
biomedich-396	236	7	017	017	NUM
biomedich-396	236	8	-	-	PUNCT
biomedich-396	236	9	2377	2377	NUM
biomedich-396	236	10	-	-	PUNCT
biomedich-396	236	11	x	x	SYM
biomedich-396	236	12	pieper	pieper	NOUN
biomedich-396	236	13	,	,	PUNCT
biomedich-396	236	14	p.	p.	PROPN
biomedich-396	236	15	,	,	PUNCT
biomedich-396	236	16	mchugh	mchugh	PROPN
biomedich-396	236	17	,	,	PUNCT
biomedich-396	236	18	e.	e.	PROPN
biomedich-396	236	19	,	,	PUNCT
biomedich-396	236	20	amaral	amaral	PROPN
biomedich-396	236	21	,	,	PUNCT
biomedich-396	236	22	m.	m.	NOUN
biomedich-396	236	23	,	,	PUNCT
biomedich-396	236	24	tempone	tempone	NOUN
biomedich-396	236	25	,	,	PUNCT
biomedich-396	236	26	a.	a.	NOUN
biomedich-396	236	27	g.	g.	PROPN
biomedich-396	236	28	,	,	PUNCT
biomedich-396	236	29	&	&	CCONJ
biomedich-396	236	30	anderson	anderson	PROPN
biomedich-396	236	31	,	,	PUNCT
biomedich-396	236	32	e.	e.	PROPN
biomedich-396	236	33	a.	a.	PROPN
biomedich-396	236	34	(	(	PUNCT
biomedich-396	236	35	2020	2020	NUM
biomedich-396	236	36	)	)	PUNCT
biomedich-396	236	37	.	.	PUNCT
biomedich-396	237	1	enantioselective	enantioselective	ADJ
biomedich-396	237	2	synthesis	synthesis	NOUN
biomedich-396	237	3	and	and	CCONJ
biomedich-396	237	4	antiparasitic	antiparasitic	ADJ
biomedich-396	237	5	properties	property	NOUN
biomedich-396	237	6	of	of	ADP
biomedich-396	237	7	aporphine	aporphine	ADJ
biomedich-396	237	8	natural	natural	ADJ
biomedich-396	237	9	products	product	NOUN
biomedich-396	237	10	.	.	PUNCT
biomedich-396	238	1	tetrahedron	tetrahedron	NOUN
biomedich-396	238	2	,	,	PUNCT
biomedich-396	238	3	76(2	76(2	NUM
biomedich-396	238	4	)	)	PUNCT
biomedich-396	238	5	,	,	PUNCT
biomedich-396	238	6	130814	130814	NUM
biomedich-396	238	7	.	.	PUNCT
biomedich-396	239	1	plazas	plazas	PROPN
biomedich-396	239	2	,	,	PUNCT
biomedich-396	239	3	e.	e.	PROPN
biomedich-396	239	4	,	,	PUNCT
biomedich-396	239	5	hagenow	hagenow	PROPN
biomedich-396	239	6	,	,	PUNCT
biomedich-396	239	7	s.	s.	PROPN
biomedich-396	239	8	,	,	PUNCT
biomedich-396	239	9	murillo	murillo	PROPN
biomedich-396	239	10	,	,	PUNCT
biomedich-396	239	11	m.	m.	NOUN
biomedich-396	239	12	a.	a.	PROPN
biomedich-396	239	13	,	,	PUNCT
biomedich-396	239	14	stark	stark	PROPN
biomedich-396	239	15	,	,	PUNCT
biomedich-396	239	16	h.	h.	PROPN
biomedich-396	239	17	,	,	PUNCT
biomedich-396	239	18	&	&	CCONJ
biomedich-396	239	19	cuca	cuca	PROPN
biomedich-396	239	20	,	,	PUNCT
biomedich-396	239	21	l.	l.	PROPN
biomedich-396	239	22	e.	e.	PROPN
biomedich-396	239	23	(	(	PUNCT
biomedich-396	239	24	2020	2020	NUM
biomedich-396	239	25	)	)	PUNCT
biomedich-396	239	26	.	.	PUNCT
biomedich-396	240	1	isoquinoline	isoquinoline	PROPN
biomedich-396	240	2	alkaloids	alkaloid	NOUN
biomedich-396	240	3	from	from	ADP
biomedich-396	240	4	the	the	DET
biomedich-396	240	5	roots	root	NOUN
biomedich-396	240	6	of	of	ADP
biomedich-396	240	7	zanthoxylum	zanthoxylum	PROPN
biomedich-396	240	8	rigidum	rigidum	PROPN
biomedich-396	240	9	as	as	ADP
biomedich-396	240	10	multi	multi	ADJ
biomedich-396	240	11	-	-	ADJ
biomedich-396	240	12	target	target	ADJ
biomedich-396	240	13	inhibitors	inhibitor	NOUN
biomedich-396	240	14	of	of	ADP
biomedich-396	240	15	cholinesterase	cholinesterase	NOUN
biomedich-396	240	16	,	,	PUNCT
biomedich-396	240	17	450	450	NUM
biomedich-396	240	18	biology	biology	NOUN
biomedich-396	240	19	,	,	PUNCT
biomedich-396	240	20	medicine	medicine	NOUN
biomedich-396	240	21	,	,	PUNCT
biomedich-396	240	22	&	&	CCONJ
biomedich-396	240	23	natural	natural	ADJ
biomedich-396	240	24	product	product	NOUN
biomedich-396	240	25	chemistry	chemistry	NOUN
biomedich-396	240	26	12	12	NUM
biomedich-396	240	27	(	(	PUNCT
biomedich-396	240	28	2	2	NUM
biomedich-396	240	29	)	)	PUNCT
biomedich-396	240	30	,	,	PUNCT
biomedich-396	240	31	2023	2023	NUM
biomedich-396	240	32	:	:	PUNCT
biomedich-396	240	33	441	441	NUM
biomedich-396	240	34	-	-	SYM
biomedich-396	240	35	450	450	NUM
biomedich-396	240	36	monoamine	monoamine	ADJ
biomedich-396	240	37	oxidase	oxidase	NOUN
biomedich-396	240	38	a	a	PRON
biomedich-396	240	39	and	and	CCONJ
biomedich-396	240	40	aβ1	aβ1	NOUN
biomedich-396	240	41	-	-	PUNCT
biomedich-396	240	42	42	42	NUM
biomedich-396	240	43	aggregation	aggregation	NOUN
biomedich-396	240	44	.	.	PUNCT
biomedich-396	241	1	bioorganic	bioorganic	ADJ
biomedich-396	241	2	chemistry	chemistry	NOUN
biomedich-396	241	3	,	,	PUNCT
biomedich-396	241	4	98	98	NUM
biomedich-396	241	5	,	,	PUNCT
biomedich-396	241	6	103722	103722	NUM
biomedich-396	241	7	.	.	PUNCT
biomedich-396	242	1	pubchem	pubchem	NOUN
biomedich-396	242	2	.	.	PUNCT
biomedich-396	243	1	(	(	PUNCT
biomedich-396	243	2	2023	2023	NUM
biomedich-396	243	3	)	)	PUNCT
biomedich-396	243	4	.	.	PUNCT
biomedich-396	244	1	protopine	protopine	PROPN
biomedich-396	244	2	compound	compound	PROPN
biomedich-396	244	3	summary	summary	PROPN
biomedich-396	244	4	pubchem	pubchem	NOUN
biomedich-396	244	5	.	.	PUNCT
biomedich-396	245	1	reddy	reddy	PROPN
biomedich-396	245	2	,	,	PUNCT
biomedich-396	245	3	t.	t.	PROPN
biomedich-396	245	4	b.	b.	PROPN
biomedich-396	245	5	k.	k.	PROPN
biomedich-396	245	6	,	,	PUNCT
biomedich-396	245	7	riley	riley	PROPN
biomedich-396	245	8	,	,	PUNCT
biomedich-396	245	9	r.	r.	PROPN
biomedich-396	245	10	,	,	PUNCT
biomedich-396	245	11	wymore	wymore	ADV
biomedich-396	245	12	,	,	PUNCT
biomedich-396	245	13	f.	f.	PROPN
biomedich-396	245	14	,	,	PUNCT
biomedich-396	245	15	montgomery	montgomery	PROPN
biomedich-396	245	16	,	,	PUNCT
biomedich-396	245	17	p.	p.	PROPN
biomedich-396	245	18	,	,	PUNCT
biomedich-396	245	19	decaprio	decaprio	PROPN
biomedich-396	245	20	,	,	PUNCT
biomedich-396	245	21	d.	d.	PROPN
biomedich-396	245	22	,	,	PUNCT
biomedich-396	245	23	engels	engels	PROPN
biomedich-396	245	24	,	,	PUNCT
biomedich-396	245	25	r.	r.	PROPN
biomedich-396	245	26	,	,	PUNCT
biomedich-396	245	27	.	.	PUNCT
biomedich-396	245	28	.	.	PUNCT
biomedich-396	245	29	.	.	PUNCT
biomedich-396	246	1	schoolnik	schoolnik	PROPN
biomedich-396	246	2	,	,	PUNCT
biomedich-396	246	3	g.	g.	PROPN
biomedich-396	246	4	k.	k.	PROPN
biomedich-396	246	5	(	(	PUNCT
biomedich-396	246	6	2008	2008	NUM
biomedich-396	246	7	)	)	PUNCT
biomedich-396	246	8	.	.	PUNCT
biomedich-396	247	1	tb	tb	ADP
biomedich-396	247	2	database	database	NOUN
biomedich-396	247	3	:	:	PUNCT
biomedich-396	247	4	an	an	DET
biomedich-396	247	5	integrated	integrate	VERB
biomedich-396	247	6	platform	platform	NOUN
biomedich-396	247	7	for	for	ADP
biomedich-396	247	8	tuberculosis	tuberculosis	NOUN
biomedich-396	247	9	research	research	NOUN
biomedich-396	247	10	.	.	PUNCT
biomedich-396	248	1	nucleic	nucleic	ADJ
biomedich-396	248	2	acids	acid	NOUN
biomedich-396	248	3	res	re	NOUN
biomedich-396	248	4	,	,	PUNCT
biomedich-396	248	5	37(suppl_1	37(suppl_1	NUM
biomedich-396	248	6	)	)	PUNCT
biomedich-396	248	7	,	,	PUNCT
biomedich-396	248	8	d499	d499	PROPN
biomedich-396	248	9	-	-	PUNCT
biomedich-396	248	10	d508	d508	PROPN
biomedich-396	248	11	.	.	PUNCT
biomedich-396	249	1	doi	doi	PROPN
biomedich-396	249	2	:	:	PUNCT
biomedich-396	249	3	10.1093	10.1093	NUM
biomedich-396	249	4	/	/	SYM
biomedich-396	249	5	nar	nar	NOUN
biomedich-396	249	6	/	/	SYM
biomedich-396	249	7	gkn652	gkn652	PROPN
biomedich-396	249	8	ruiru	ruiru	PROPN
biomedich-396	249	9	,	,	PUNCT
biomedich-396	249	10	s.	s.	PROPN
biomedich-396	249	11	,	,	PUNCT
biomedich-396	249	12	&	&	CCONJ
biomedich-396	249	13	isamu	isamu	PROPN
biomedich-396	249	14	,	,	PUNCT
biomedich-396	249	15	s.	s.	PROPN
biomedich-396	249	16	(	(	PUNCT
biomedich-396	249	17	2013	2013	NUM
biomedich-396	249	18	)	)	PUNCT
biomedich-396	249	19	.	.	PUNCT
biomedich-396	250	1	pathophysiology	pathophysiology	NOUN
biomedich-396	250	2	of	of	ADP
biomedich-396	250	3	tuberculosis	tuberculosis	NOUN
biomedich-396	250	4	.	.	PUNCT
biomedich-396	251	1	in	in	ADP
biomedich-396	251	2	h.	h.	PROPN
biomedich-396	251	3	m.	m.	PROPN
biomedich-396	251	4	bassam	bassam	PROPN
biomedich-396	251	5	&	&	CCONJ
biomedich-396	251	6	g.	g.	PROPN
biomedich-396	252	1	v.	v.	PROPN
biomedich-396	252	2	mayank	mayank	PROPN
biomedich-396	252	3	(	(	PUNCT
biomedich-396	252	4	eds	eds	PROPN
biomedich-396	252	5	.	.	PUNCT
biomedich-396	252	6	)	)	PUNCT
biomedich-396	252	7	,	,	PUNCT
biomedich-396	252	8	tuberculosis	tuberculosis	INTJ
biomedich-396	252	9	(	(	PUNCT
biomedich-396	252	10	pp	pp	ADJ
biomedich-396	252	11	.	.	PUNCT
biomedich-396	253	1	ch	ch	NOUN
biomedich-396	253	2	.	.	PROPN
biomedich-396	253	3	7	7	NUM
biomedich-396	253	4	)	)	PUNCT
biomedich-396	253	5	.	.	PUNCT
biomedich-396	254	1	rijeka	rijeka	PROPN
biomedich-396	254	2	:	:	PUNCT
biomedich-396	254	3	intechopen	intechopen	ADJ
biomedich-396	254	4	.	.	PUNCT
biomedich-396	255	1	russom	russom	NOUN
biomedich-396	255	2	,	,	PUNCT
biomedich-396	255	3	m.	m.	NOUN
biomedich-396	255	4	,	,	PUNCT
biomedich-396	255	5	berhane	berhane	NOUN
biomedich-396	255	6	,	,	PUNCT
biomedich-396	255	7	a.	a.	NOUN
biomedich-396	255	8	,	,	PUNCT
biomedich-396	255	9	debesai	debesai	PROPN
biomedich-396	255	10	,	,	PUNCT
biomedich-396	255	11	m.	m.	NOUN
biomedich-396	255	12	,	,	PUNCT
biomedich-396	255	13	andom	andom	NOUN
biomedich-396	255	14	,	,	PUNCT
biomedich-396	255	15	h.	h.	PROPN
biomedich-396	255	16	,	,	PUNCT
biomedich-396	255	17	tesfai	tesfai	PROPN
biomedich-396	255	18	,	,	PUNCT
biomedich-396	255	19	d.	d.	PROPN
biomedich-396	255	20	,	,	PUNCT
biomedich-396	255	21	&	&	CCONJ
biomedich-396	255	22	zeremariam	zeremariam	PROPN
biomedich-396	255	23	,	,	PUNCT
biomedich-396	255	24	z.	z.	PROPN
biomedich-396	255	25	(	(	PUNCT
biomedich-396	255	26	2019	2019	NUM
biomedich-396	255	27	)	)	PUNCT
biomedich-396	255	28	.	.	PUNCT
biomedich-396	256	1	challenges	challenge	NOUN
biomedich-396	256	2	of	of	ADP
biomedich-396	256	3	hepatotoxicity	hepatotoxicity	NOUN
biomedich-396	256	4	associated	associate	VERB
biomedich-396	256	5	with	with	ADP
biomedich-396	256	6	isoniazid	isoniazid	NOUN
biomedich-396	256	7	preventive	preventive	ADJ
biomedich-396	256	8	therapy	therapy	NOUN
biomedich-396	256	9	among	among	ADP
biomedich-396	256	10	people	people	NOUN
biomedich-396	256	11	living	live	VERB
biomedich-396	256	12	with	with	ADP
biomedich-396	256	13	hiv	hiv	PROPN
biomedich-396	256	14	in	in	ADP
biomedich-396	256	15	eritrea	eritrea	PROPN
biomedich-396	256	16	.	.	PUNCT
biomedich-396	257	1	adv	adv	PROPN
biomedich-396	257	2	pharmacoepidemiol	pharmacoepidemiol	PROPN
biomedich-396	257	3	drug	drug	PROPN
biomedich-396	257	4	saf	saf	PROPN
biomedich-396	257	5	,	,	PUNCT
biomedich-396	257	6	8(2	8(2	NUM
biomedich-396	257	7	)	)	PUNCT
biomedich-396	257	8	,	,	PUNCT
biomedich-396	257	9	2167	2167	NUM
biomedich-396	257	10	-	-	SYM
biomedich-396	257	11	1052.2119	1052.2119	NUM
biomedich-396	257	12	.	.	PUNCT
biomedich-396	258	1	russom	russom	NOUN
biomedich-396	258	2	,	,	PUNCT
biomedich-396	258	3	m.	m.	NOUN
biomedich-396	258	4	,	,	PUNCT
biomedich-396	258	5	debesai	debesai	PROPN
biomedich-396	258	6	,	,	PUNCT
biomedich-396	258	7	m.	m.	NOUN
biomedich-396	258	8	,	,	PUNCT
biomedich-396	258	9	zeregabr	zeregabr	NOUN
biomedich-396	258	10	,	,	PUNCT
biomedich-396	258	11	m.	m.	NOUN
biomedich-396	258	12	,	,	PUNCT
biomedich-396	258	13	berhane	berhane	NOUN
biomedich-396	258	14	,	,	PUNCT
biomedich-396	258	15	a.	a.	NOUN
biomedich-396	258	16	,	,	PUNCT
biomedich-396	258	17	tekeste	tekeste	NOUN
biomedich-396	258	18	,	,	PUNCT
biomedich-396	258	19	t.	t.	PROPN
biomedich-396	258	20	,	,	PUNCT
biomedich-396	258	21	&	&	CCONJ
biomedich-396	258	22	teklesenbet	teklesenbet	PROPN
biomedich-396	258	23	,	,	PUNCT
biomedich-396	258	24	t.	t.	PROPN
biomedich-396	258	25	(	(	PUNCT
biomedich-396	258	26	2018	2018	NUM
biomedich-396	258	27	)	)	PUNCT
biomedich-396	258	28	.	.	PUNCT
biomedich-396	259	1	serious	serious	ADJ
biomedich-396	259	2	hepatotoxicity	hepatotoxicity	NOUN
biomedich-396	259	3	following	follow	VERB
biomedich-396	259	4	use	use	NOUN
biomedich-396	259	5	of	of	ADP
biomedich-396	259	6	isoniazid	isoniazid	NOUN
biomedich-396	259	7	preventive	preventive	ADJ
biomedich-396	259	8	therapy	therapy	NOUN
biomedich-396	259	9	in	in	ADP
biomedich-396	259	10	hiv	hiv	PROPN
biomedich-396	259	11	patients	patient	NOUN
biomedich-396	259	12	in	in	ADP
biomedich-396	259	13	eritrea	eritrea	PROPN
biomedich-396	259	14	.	.	PUNCT
biomedich-396	260	1	pharmacology	pharmacology	NOUN
biomedich-396	260	2	research	research	PROPN
biomedich-396	260	3	&	&	CCONJ
biomedich-396	260	4	perspectives	perspective	NOUN
biomedich-396	260	5	,	,	PUNCT
biomedich-396	260	6	6(4	6(4	NOUN
biomedich-396	260	7	)	)	PUNCT
biomedich-396	260	8	,	,	PUNCT
biomedich-396	260	9	e00423	e00423	PROPN
biomedich-396	260	10	.	.	PROPN
biomedich-396	260	11	sharma	sharma	PROPN
biomedich-396	260	12	,	,	PUNCT
biomedich-396	260	13	s.	s.	PROPN
biomedich-396	260	14	,	,	PUNCT
biomedich-396	260	15	sharma	sharma	PROPN
biomedich-396	260	16	,	,	PUNCT
biomedich-396	260	17	a.	a.	PROPN
biomedich-396	260	18	,	,	PUNCT
biomedich-396	260	19	&	&	CCONJ
biomedich-396	260	20	gupta	gupta	PROPN
biomedich-396	260	21	,	,	PUNCT
biomedich-396	260	22	u.	u.	NOUN
biomedich-396	260	23	(	(	PUNCT
biomedich-396	260	24	2021	2021	NUM
biomedich-396	260	25	)	)	PUNCT
biomedich-396	260	26	.	.	PUNCT
biomedich-396	261	1	molecular	molecular	ADJ
biomedich-396	261	2	docking	docking	NOUN
biomedich-396	261	3	studies	study	NOUN
biomedich-396	261	4	on	on	ADP
biomedich-396	261	5	the	the	DET
biomedich-396	261	6	anti	anti	ADJ
biomedich-396	261	7	-	-	ADJ
biomedich-396	261	8	fungal	fungal	ADJ
biomedich-396	261	9	activity	activity	NOUN
biomedich-396	261	10	of	of	ADP
biomedich-396	261	11	allium	allium	NOUN
biomedich-396	261	12	sativum	sativum	NOUN
biomedich-396	261	13	(	(	PUNCT
biomedich-396	261	14	garlic	garlic	NOUN
biomedich-396	261	15	)	)	PUNCT
biomedich-396	261	16	against	against	ADP
biomedich-396	261	17	mucormycosis	mucormycosis	NOUN
biomedich-396	261	18	(	(	PUNCT
biomedich-396	261	19	black	black	ADJ
biomedich-396	261	20	fungus	fungus	NOUN
biomedich-396	261	21	)	)	PUNCT
biomedich-396	261	22	by	by	ADP
biomedich-396	261	23	biovia	biovia	PROPN
biomedich-396	261	24	discovery	discovery	PROPN
biomedich-396	261	25	studio	studio	PROPN
biomedich-396	261	26	visualizer	visualizer	NOUN
biomedich-396	261	27	21.1	21.1	NUM
biomedich-396	261	28	.	.	PUNCT
biomedich-396	262	1	0.0	0.0	NUM
biomedich-396	262	2	.	.	PUNCT
biomedich-396	262	3	son	son	PROPN
biomedich-396	262	4	,	,	PUNCT
biomedich-396	262	5	y.	y.	PROPN
biomedich-396	262	6	,	,	PUNCT
biomedich-396	262	7	an	an	PRON
biomedich-396	262	8	,	,	PUNCT
biomedich-396	262	9	y.	y.	PROPN
biomedich-396	262	10	,	,	PUNCT
biomedich-396	262	11	jung	jung	PROPN
biomedich-396	262	12	,	,	PUNCT
biomedich-396	262	13	j.	j.	PROPN
biomedich-396	262	14	,	,	PUNCT
biomedich-396	262	15	shin	shin	PROPN
biomedich-396	262	16	,	,	PUNCT
biomedich-396	262	17	s.	s.	PROPN
biomedich-396	262	18	,	,	PUNCT
biomedich-396	262	19	park	park	NOUN
biomedich-396	262	20	,	,	PUNCT
biomedich-396	262	21	i.	i.	NOUN
biomedich-396	262	22	,	,	PUNCT
biomedich-396	262	23	gwak	gwak	PROPN
biomedich-396	262	24	,	,	PUNCT
biomedich-396	262	25	j.	j.	PROPN
biomedich-396	262	26	,	,	PUNCT
biomedich-396	262	27	.	.	PUNCT
biomedich-396	262	28	.	.	PUNCT
biomedich-396	262	29	.	.	PUNCT
biomedich-396	263	1	oh	oh	INTJ
biomedich-396	263	2	,	,	PUNCT
biomedich-396	263	3	s.	s.	PROPN
biomedich-396	263	4	(	(	PUNCT
biomedich-396	263	5	2019	2019	NUM
biomedich-396	263	6	)	)	PUNCT
biomedich-396	263	7	.	.	PUNCT
biomedich-396	264	1	protopine	protopine	PROPN
biomedich-396	264	2	isolated	isolate	VERB
biomedich-396	264	3	from	from	ADP
biomedich-396	264	4	nandina	nandina	PROPN
biomedich-396	264	5	domestica	domestica	PROPN
biomedich-396	264	6	induces	induce	VERB
biomedich-396	264	7	apoptosis	apoptosis	NOUN
biomedich-396	264	8	and	and	CCONJ
biomedich-396	264	9	autophagy	autophagy	NOUN
biomedich-396	264	10	in	in	ADP
biomedich-396	264	11	colon	colon	NOUN
biomedich-396	264	12	cancer	cancer	NOUN
biomedich-396	264	13	cells	cell	NOUN
biomedich-396	264	14	by	by	ADP
biomedich-396	264	15	stabilizing	stabilize	VERB
biomedich-396	264	16	p53	p53	NOUN
biomedich-396	264	17	.	.	PUNCT
biomedich-396	265	1	phytotherapy	phytotherapy	NOUN
biomedich-396	265	2	research	research	NOUN
biomedich-396	265	3	,	,	PUNCT
biomedich-396	265	4	33(6	33(6	PROPN
biomedich-396	265	5	)	)	PUNCT
biomedich-396	265	6	,	,	PUNCT
biomedich-396	265	7	1689	1689	NUM
biomedich-396	265	8	-	-	SYM
biomedich-396	265	9	1696	1696	NUM
biomedich-396	265	10	.	.	PUNCT
biomedich-396	266	1	sreenivasmurthy	sreenivasmurthy	NOUN
biomedich-396	266	2	,	,	PUNCT
biomedich-396	266	3	s.	s.	PROPN
biomedich-396	266	4	g.	g.	PROPN
biomedich-396	266	5	,	,	PUNCT
biomedich-396	266	6	iyaswamy	iyaswamy	NOUN
biomedich-396	266	7	,	,	PUNCT
biomedich-396	266	8	a.	a.	NOUN
biomedich-396	266	9	,	,	PUNCT
biomedich-396	266	10	krishnamoorthi	krishnamoorthi	PROPN
biomedich-396	266	11	,	,	PUNCT
biomedich-396	266	12	s.	s.	PROPN
biomedich-396	266	13	,	,	PUNCT
biomedich-396	266	14	senapati	senapati	PROPN
biomedich-396	266	15	,	,	PUNCT
biomedich-396	266	16	s.	s.	PROPN
biomedich-396	266	17	,	,	PUNCT
biomedich-396	266	18	malampati	malampati	PROPN
biomedich-396	266	19	,	,	PUNCT
biomedich-396	266	20	s.	s.	PROPN
biomedich-396	266	21	,	,	PUNCT
biomedich-396	266	22	zhu	zhu	PROPN
biomedich-396	266	23	,	,	PUNCT
biomedich-396	266	24	z.	z.	PROPN
biomedich-396	266	25	,	,	PUNCT
biomedich-396	266	26	.	.	PUNCT
biomedich-396	266	27	.	.	PUNCT
biomedich-396	266	28	.	.	PUNCT
biomedich-396	267	1	tong	tong	PROPN
biomedich-396	267	2	,	,	PUNCT
biomedich-396	267	3	b.	b.	PROPN
biomedich-396	267	4	c.-k	c.-k	PROPN
biomedich-396	267	5	.	.	PUNCT
biomedich-396	268	1	(	(	PUNCT
biomedich-396	268	2	2022	2022	NUM
biomedich-396	268	3	)	)	PUNCT
biomedich-396	268	4	.	.	PUNCT
biomedich-396	269	1	protopine	protopine	PROPN
biomedich-396	269	2	promotes	promote	VERB
biomedich-396	269	3	the	the	DET
biomedich-396	269	4	proteasomal	proteasomal	ADJ
biomedich-396	269	5	degradation	degradation	NOUN
biomedich-396	269	6	of	of	ADP
biomedich-396	269	7	pathological	pathological	ADJ
biomedich-396	269	8	tau	tau	PROPN
biomedich-396	269	9	in	in	ADP
biomedich-396	269	10	alzheimer	alzheimer	PROPN
biomedich-396	269	11	's	's	PART
biomedich-396	269	12	disease	disease	NOUN
biomedich-396	269	13	models	model	NOUN
biomedich-396	269	14	via	via	ADP
biomedich-396	269	15	hdac6	hdac6	NOUN
biomedich-396	269	16	inhibition	inhibition	NOUN
biomedich-396	269	17	.	.	PUNCT
biomedich-396	270	1	phytomedicine	phytomedicine	NOUN
biomedich-396	270	2	,	,	PUNCT
biomedich-396	270	3	96	96	NUM
biomedich-396	270	4	,	,	PUNCT
biomedich-396	270	5	153887	153887	NUM
biomedich-396	270	6	.	.	PUNCT
biomedich-396	271	1	takayama	takayama	PROPN
biomedich-396	271	2	,	,	PUNCT
biomedich-396	271	3	k.	k.	PROPN
biomedich-396	271	4	,	,	PUNCT
biomedich-396	271	5	wang	wang	PROPN
biomedich-396	271	6	,	,	PUNCT
biomedich-396	271	7	c.	c.	PROPN
biomedich-396	271	8	,	,	PUNCT
biomedich-396	271	9	&	&	CCONJ
biomedich-396	271	10	besra	besra	PROPN
biomedich-396	271	11	,	,	PUNCT
biomedich-396	271	12	g.	g.	PROPN
biomedich-396	271	13	s.	s.	PROPN
biomedich-396	271	14	(	(	PUNCT
biomedich-396	271	15	2005	2005	NUM
biomedich-396	271	16	)	)	PUNCT
biomedich-396	271	17	.	.	PUNCT
biomedich-396	272	1	pathway	pathway	NOUN
biomedich-396	272	2	to	to	PART
biomedich-396	272	3	synthesis	synthesis	VERB
biomedich-396	272	4	and	and	CCONJ
biomedich-396	272	5	processing	processing	NOUN
biomedich-396	272	6	of	of	ADP
biomedich-396	272	7	mycolic	mycolic	ADJ
biomedich-396	272	8	acids	acid	NOUN
biomedich-396	272	9	in	in	ADP
biomedich-396	272	10	mycobacterium	mycobacterium	NOUN
biomedich-396	272	11	tuberculosis	tuberculosis	NOUN
biomedich-396	272	12	.	.	PUNCT
biomedich-396	273	1	clin	clin	PROPN
biomedich-396	273	2	microbiol	microbiol	PROPN
biomedich-396	273	3	rev	rev	VERB
biomedich-396	273	4	,	,	PUNCT
biomedich-396	273	5	18(1	18(1	NOUN
biomedich-396	273	6	)	)	PUNCT
biomedich-396	273	7	,	,	PUNCT
biomedich-396	273	8	81	81	NUM
biomedich-396	273	9	-	-	SYM
biomedich-396	273	10	101	101	NUM
biomedich-396	273	11	.	.	PUNCT
biomedich-396	274	1	doi	doi	NOUN
biomedich-396	274	2	:	:	PUNCT
biomedich-396	274	3	10.1128	10.1128	NUM
biomedich-396	274	4	/	/	SYM
biomedich-396	274	5	cmr.18.1.81	cmr.18.1.81	NOUN
biomedich-396	274	6	-	-	SYM
biomedich-396	274	7	101.2005	101.2005	NUM
biomedich-396	274	8	torres	torre	NOUN
biomedich-396	274	9	,	,	PUNCT
biomedich-396	274	10	p.	p.	NOUN
biomedich-396	274	11	h.	h.	PROPN
biomedich-396	274	12	m.	m.	PROPN
biomedich-396	274	13	,	,	PUNCT
biomedich-396	274	14	sodero	sodero	NOUN
biomedich-396	274	15	,	,	PUNCT
biomedich-396	274	16	a.	a.	PROPN
biomedich-396	274	17	c.	c.	PROPN
biomedich-396	274	18	r.	r.	PROPN
biomedich-396	274	19	,	,	PUNCT
biomedich-396	274	20	&	&	CCONJ
biomedich-396	274	21	jofily	jofily	ADV
biomedich-396	274	22	,	,	PUNCT
biomedich-396	274	23	p.	p.	NOUN
biomedich-396	274	24	(	(	PUNCT
biomedich-396	274	25	2019	2019	NUM
biomedich-396	274	26	)	)	PUNCT
biomedich-396	274	27	.	.	PUNCT
biomedich-396	275	1	key	key	ADJ
biomedich-396	275	2	topics	topic	NOUN
biomedich-396	275	3	in	in	ADP
biomedich-396	275	4	molecular	molecular	ADJ
biomedich-396	275	5	docking	docking	NOUN
biomedich-396	275	6	for	for	ADP
biomedich-396	275	7	drug	drug	NOUN
biomedich-396	275	8	design	design	NOUN
biomedich-396	275	9	.	.	PUNCT
biomedich-396	276	1	20(18	20(18	NUM
biomedich-396	276	2	)	)	PUNCT
biomedich-396	276	3	.	.	PUNCT
biomedich-396	277	1	doi	doi	NOUN
biomedich-396	277	2	:	:	PUNCT
biomedich-396	277	3	10.3390	10.3390	NUM
biomedich-396	277	4	/	/	SYM
biomedich-396	277	5	ijms20184574	ijms20184574	NOUN
biomedich-396	277	6	unissa	unissa	NOUN
biomedich-396	277	7	,	,	PUNCT
biomedich-396	277	8	a.	a.	NOUN
biomedich-396	277	9	n.	n.	NOUN
biomedich-396	277	10	,	,	PUNCT
biomedich-396	277	11	subbian	subbian	PROPN
biomedich-396	277	12	,	,	PUNCT
biomedich-396	277	13	s.	s.	PROPN
biomedich-396	277	14	,	,	PUNCT
biomedich-396	277	15	hanna	hanna	PROPN
biomedich-396	277	16	,	,	PUNCT
biomedich-396	277	17	l.	l.	PROPN
biomedich-396	277	18	e.	e.	PROPN
biomedich-396	277	19	,	,	PUNCT
biomedich-396	277	20	&	&	CCONJ
biomedich-396	277	21	selvakumar	selvakumar	PROPN
biomedich-396	277	22	,	,	PUNCT
biomedich-396	277	23	n.	n.	PROPN
biomedich-396	277	24	(	(	PUNCT
biomedich-396	277	25	2016	2016	NUM
biomedich-396	277	26	)	)	PUNCT
biomedich-396	277	27	.	.	PUNCT
biomedich-396	278	1	overview	overview	NOUN
biomedich-396	278	2	on	on	ADP
biomedich-396	278	3	mechanisms	mechanism	NOUN
biomedich-396	278	4	of	of	ADP
biomedich-396	278	5	isoniazid	isoniazid	NOUN
biomedich-396	278	6	action	action	NOUN
biomedich-396	278	7	and	and	CCONJ
biomedich-396	278	8	resistance	resistance	NOUN
biomedich-396	278	9	in	in	ADP
biomedich-396	278	10	mycobacterium	mycobacterium	NOUN
biomedich-396	278	11	tuberculosis	tuberculosis	NOUN
biomedich-396	278	12	.	.	PUNCT
biomedich-396	279	1	infection	infection	NOUN
biomedich-396	279	2	,	,	PUNCT
biomedich-396	279	3	genetics	genetic	NOUN
biomedich-396	279	4	and	and	CCONJ
biomedich-396	279	5	evolution	evolution	NOUN
biomedich-396	279	6	,	,	PUNCT
biomedich-396	279	7	45	45	NUM
biomedich-396	279	8	,	,	PUNCT
biomedich-396	279	9	474	474	NUM
biomedich-396	279	10	-	-	SYM
biomedich-396	279	11	492	492	NUM
biomedich-396	279	12	.	.	PUNCT
biomedich-396	280	1	doi	doi	NOUN
biomedich-396	280	2	:	:	PUNCT
biomedich-396	280	3	https://doi.org/10.1016/j.meegid.2016.09.004	https://doi.org/10.1016/j.meegid.2016.09.004	NOUN
biomedich-396	280	4	valipour	valipour	NOUN
biomedich-396	280	5	,	,	PUNCT
biomedich-396	280	6	m.	m.	NOUN
biomedich-396	280	7	,	,	PUNCT
biomedich-396	280	8	zarghi	zarghi	PROPN
biomedich-396	280	9	,	,	PUNCT
biomedich-396	280	10	a.	a.	NOUN
biomedich-396	280	11	,	,	PUNCT
biomedich-396	280	12	ebrahimzadeh	ebrahimzadeh	NOUN
biomedich-396	280	13	,	,	PUNCT
biomedich-396	280	14	m.	m.	NOUN
biomedich-396	280	15	a.	a.	PROPN
biomedich-396	280	16	,	,	PUNCT
biomedich-396	280	17	&	&	CCONJ
biomedich-396	280	18	irannejad	irannejad	PROPN
biomedich-396	280	19	,	,	PUNCT
biomedich-396	280	20	h.	h.	PROPN
biomedich-396	280	21	(	(	PUNCT
biomedich-396	280	22	2021	2021	NUM
biomedich-396	280	23	)	)	PUNCT
biomedich-396	280	24	.	.	PUNCT
biomedich-396	281	1	therapeutic	therapeutic	ADJ
biomedich-396	281	2	potential	potential	NOUN
biomedich-396	281	3	of	of	ADP
biomedich-396	281	4	chelerythrine	chelerythrine	NOUN
biomedich-396	281	5	as	as	ADP
biomedich-396	281	6	a	a	DET
biomedich-396	281	7	multipurpose	multipurpose	NOUN
biomedich-396	281	8	adjuvant	adjuvant	ADJ
biomedich-396	281	9	for	for	ADP
biomedich-396	281	10	the	the	DET
biomedich-396	281	11	treatment	treatment	NOUN
biomedich-396	281	12	of	of	ADP
biomedich-396	281	13	covid-19	covid-19	PROPN
biomedich-396	281	14	.	.	PUNCT
biomedich-396	281	15	cell	cell	NOUN
biomedich-396	281	16	cycle	cycle	NOUN
biomedich-396	281	17	,	,	PUNCT
biomedich-396	281	18	20(22	20(22	NUM
biomedich-396	281	19	)	)	PUNCT
biomedich-396	281	20	,	,	PUNCT
biomedich-396	281	21	2321	2321	NUM
biomedich-396	281	22	-	-	SYM
biomedich-396	281	23	2336	2336	NUM
biomedich-396	281	24	.	.	PUNCT
biomedich-396	282	1	vilchèze	vilchèze	PROPN
biomedich-396	282	2	,	,	PUNCT
biomedich-396	282	3	c.	c.	PROPN
biomedich-396	282	4	,	,	PUNCT
biomedich-396	282	5	&	&	CCONJ
biomedich-396	282	6	jacobs	jacobs	PROPN
biomedich-396	282	7	,	,	PUNCT
biomedich-396	282	8	w.	w.	PROPN
biomedich-396	282	9	r.	r.	PROPN
biomedich-396	282	10	(	(	PUNCT
biomedich-396	282	11	2019	2019	NUM
biomedich-396	282	12	)	)	PUNCT
biomedich-396	282	13	.	.	PUNCT
biomedich-396	283	1	the	the	DET
biomedich-396	283	2	isoniazid	isoniazid	NOUN
biomedich-396	283	3	paradigm	paradigm	NOUN
biomedich-396	283	4	of	of	ADP
biomedich-396	283	5	killing	killing	NOUN
biomedich-396	283	6	,	,	PUNCT
biomedich-396	283	7	resistance	resistance	NOUN
biomedich-396	283	8	,	,	PUNCT
biomedich-396	283	9	and	and	CCONJ
biomedich-396	283	10	persistence	persistence	NOUN
biomedich-396	283	11	in	in	ADP
biomedich-396	283	12	mycobacterium	mycobacterium	NOUN
biomedich-396	283	13	tuberculosis	tuberculosis	NOUN
biomedich-396	283	14	.	.	PUNCT
biomedich-396	284	1	journal	journal	NOUN
biomedich-396	284	2	of	of	ADP
biomedich-396	284	3	molecular	molecular	ADJ
biomedich-396	284	4	biology	biology	NOUN
biomedich-396	284	5	,	,	PUNCT
biomedich-396	284	6	431(18	431(18	NUM
biomedich-396	284	7	)	)	PUNCT
biomedich-396	284	8	,	,	PUNCT
biomedich-396	284	9	34503461	34503461	NUM
biomedich-396	284	10	.	.	PUNCT
biomedich-396	285	1	doi	doi	NOUN
biomedich-396	285	2	:	:	PUNCT
biomedich-396	285	3	https://doi.org/10.1016/j.jmb.2019.02.016	https://doi.org/10.1016/j.jmb.2019.02.016	PROPN
biomedich-396	285	4	wang	wang	PROPN
biomedich-396	285	5	,	,	PUNCT
biomedich-396	285	6	b.	b.	PROPN
biomedich-396	285	7	,	,	PUNCT
biomedich-396	285	8	zhao	zhao	PROPN
biomedich-396	285	9	,	,	PUNCT
biomedich-396	285	10	y.-j	y.-j	PROPN
biomedich-396	285	11	.	.	PROPN
biomedich-396	285	12	,	,	PUNCT
biomedich-396	285	13	zhao	zhao	NOUN
biomedich-396	285	14	,	,	PUNCT
biomedich-396	285	15	y.-l	y.-l	NOUN
biomedich-396	285	16	.	.	PUNCT
biomedich-396	285	17	,	,	PUNCT
biomedich-396	285	18	liu	liu	PROPN
biomedich-396	285	19	,	,	PUNCT
biomedich-396	285	20	y.-p	y.-p	PROPN
biomedich-396	285	21	.	.	PROPN
biomedich-396	285	22	,	,	PUNCT
biomedich-396	285	23	li	li	PROPN
biomedich-396	285	24	,	,	PUNCT
biomedich-396	285	25	x.-n	x.-n	PROPN
biomedich-396	285	26	.	.	PROPN
biomedich-396	285	27	,	,	PUNCT
biomedich-396	285	28	zhang	zhang	PROPN
biomedich-396	285	29	,	,	PUNCT
biomedich-396	285	30	h.	h.	PROPN
biomedich-396	285	31	,	,	PUNCT
biomedich-396	285	32	&	&	CCONJ
biomedich-396	285	33	luo	luo	PROPN
biomedich-396	285	34	,	,	PUNCT
biomedich-396	285	35	x.-d	x.-d	PROPN
biomedich-396	285	36	.	.	PUNCT
biomedich-396	286	1	(	(	PUNCT
biomedich-396	286	2	2019	2019	NUM
biomedich-396	286	3	)	)	PUNCT
biomedich-396	286	4	.	.	PUNCT
biomedich-396	287	1	exploring	explore	VERB
biomedich-396	287	2	aporphine	aporphine	NOUN
biomedich-396	287	3	as	as	ADP
biomedich-396	287	4	antiinflammatory	antiinflammatory	NOUN
biomedich-396	287	5	and	and	CCONJ
biomedich-396	287	6	analgesic	analgesic	ADJ
biomedich-396	287	7	lead	lead	NOUN
biomedich-396	287	8	from	from	ADP
biomedich-396	287	9	dactylicapnos	dactylicapno	NOUN
biomedich-396	287	10	scandens	scanden	NOUN
biomedich-396	287	11	.	.	PUNCT
biomedich-396	288	1	organic	organic	ADJ
biomedich-396	288	2	letters	letter	NOUN
biomedich-396	288	3	,	,	PUNCT
biomedich-396	288	4	22(1	22(1	NUM
biomedich-396	288	5	)	)	PUNCT
biomedich-396	288	6	,	,	PUNCT
biomedich-396	288	7	257	257	NUM
biomedich-396	288	8	-	-	SYM
biomedich-396	288	9	260	260	NUM
biomedich-396	288	10	.	.	PUNCT
biomedich-396	289	1	wang	wang	PROPN
biomedich-396	289	2	,	,	PUNCT
biomedich-396	289	3	r.	r.	PROPN
biomedich-396	289	4	,	,	PUNCT
biomedich-396	289	5	zhou	zhou	PROPN
biomedich-396	289	6	,	,	PUNCT
biomedich-396	289	7	j.	j.	PROPN
biomedich-396	289	8	,	,	PUNCT
biomedich-396	289	9	shi	shi	PROPN
biomedich-396	289	10	,	,	PUNCT
biomedich-396	289	11	g.	g.	PROPN
biomedich-396	289	12	,	,	PUNCT
biomedich-396	289	13	liu	liu	PROPN
biomedich-396	289	14	,	,	PUNCT
biomedich-396	289	15	y.	y.	PROPN
biomedich-396	289	16	,	,	PUNCT
biomedich-396	289	17	&	&	CCONJ
biomedich-396	289	18	yu	yu	PROPN
biomedich-396	289	19	,	,	PUNCT
biomedich-396	289	20	d.	d.	PROPN
biomedich-396	289	21	(	(	PUNCT
biomedich-396	289	22	2020	2020	NUM
biomedich-396	289	23	)	)	PUNCT
biomedich-396	289	24	.	.	PUNCT
biomedich-396	290	1	aporphine	aporphine	PROPN
biomedich-396	290	2	and	and	CCONJ
biomedich-396	290	3	phenanthrene	phenanthrene	NOUN
biomedich-396	290	4	alkaloids	alkaloid	NOUN
biomedich-396	290	5	with	with	ADP
biomedich-396	290	6	antioxidant	antioxidant	ADJ
biomedich-396	290	7	activity	activity	NOUN
biomedich-396	290	8	from	from	ADP
biomedich-396	290	9	the	the	DET
biomedich-396	290	10	roots	root	NOUN
biomedich-396	290	11	of	of	ADP
biomedich-396	290	12	stephania	stephania	NOUN
biomedich-396	290	13	tetrandra	tetrandra	NOUN
biomedich-396	290	14	.	.	PUNCT
biomedich-396	291	1	fitoterapia	fitoterapia	PROPN
biomedich-396	291	2	,	,	PUNCT
biomedich-396	291	3	143	143	NUM
biomedich-396	291	4	,	,	PUNCT
biomedich-396	291	5	104551	104551	NUM
biomedich-396	291	6	.	.	PUNCT
biomedich-396	292	1	wang	wang	PROPN
biomedich-396	292	2	,	,	PUNCT
biomedich-396	292	3	y.	y.	PROPN
biomedich-396	292	4	,	,	PUNCT
biomedich-396	292	5	ribeiro	ribeiro	PROPN
biomedich-396	292	6	,	,	PUNCT
biomedich-396	292	7	j.	j.	PROPN
biomedich-396	292	8	m.	m.	PROPN
biomedich-396	292	9	l.	l.	PROPN
biomedich-396	292	10	,	,	PUNCT
biomedich-396	292	11	&	&	CCONJ
biomedich-396	292	12	tiwary	tiwary	PROPN
biomedich-396	292	13	,	,	PUNCT
biomedich-396	292	14	p.	p.	NOUN
biomedich-396	292	15	(	(	PUNCT
biomedich-396	292	16	2020	2020	NUM
biomedich-396	292	17	)	)	PUNCT
biomedich-396	292	18	.	.	PUNCT
biomedich-396	293	1	machine	machine	NOUN
biomedich-396	293	2	learning	learn	VERB
biomedich-396	293	3	approaches	approach	VERB
biomedich-396	293	4	for	for	ADP
biomedich-396	293	5	analyzing	analyze	VERB
biomedich-396	293	6	and	and	CCONJ
biomedich-396	293	7	enhancing	enhance	VERB
biomedich-396	293	8	molecular	molecular	ADJ
biomedich-396	293	9	dynamics	dynamic	NOUN
biomedich-396	293	10	simulations	simulation	NOUN
biomedich-396	293	11	.	.	PUNCT
biomedich-396	294	1	current	current	ADJ
biomedich-396	294	2	opinion	opinion	NOUN
biomedich-396	294	3	in	in	ADP
biomedich-396	294	4	structural	structural	ADJ
biomedich-396	294	5	biology	biology	NOUN
biomedich-396	294	6	,	,	PUNCT
biomedich-396	294	7	61	61	NUM
biomedich-396	294	8	,	,	PUNCT
biomedich-396	294	9	139	139	NUM
biomedich-396	294	10	-	-	SYM
biomedich-396	294	11	145	145	NUM
biomedich-396	294	12	.	.	PUNCT
biomedich-396	295	1	who	who	PRON
biomedich-396	295	2	.	.	PUNCT
biomedich-396	296	1	(	(	PUNCT
biomedich-396	296	2	2023	2023	NUM
biomedich-396	296	3	)	)	PUNCT
biomedich-396	296	4	.	.	PUNCT
biomedich-396	297	1	epidemological	epidemological	ADJ
biomedich-396	297	2	statistics	statistic	NOUN
biomedich-396	297	3	on	on	ADP
biomedich-396	297	4	tuberculosis	tuberculosis	NOUN
biomedich-396	297	5	.	.	PUNCT
biomedich-396	298	1	zhang	zhang	PROPN
biomedich-396	298	2	,	,	PUNCT
biomedich-396	298	3	b.	b.	PROPN
biomedich-396	298	4	,	,	PUNCT
biomedich-396	298	5	zeng	zeng	PROPN
biomedich-396	298	6	,	,	PUNCT
biomedich-396	298	7	m.	m.	NOUN
biomedich-396	298	8	,	,	PUNCT
biomedich-396	298	9	li	li	PROPN
biomedich-396	298	10	,	,	PUNCT
biomedich-396	298	11	m.	m.	NOUN
biomedich-396	298	12	,	,	PUNCT
biomedich-396	298	13	kan	kan	PROPN
biomedich-396	298	14	,	,	PUNCT
biomedich-396	298	15	y.	y.	PROPN
biomedich-396	298	16	,	,	PUNCT
biomedich-396	298	17	li	li	PROPN
biomedich-396	298	18	,	,	PUNCT
biomedich-396	298	19	b.	b.	PROPN
biomedich-396	298	20	,	,	PUNCT
biomedich-396	298	21	xu	xu	PROPN
biomedich-396	298	22	,	,	PUNCT
biomedich-396	298	23	r.	r.	PROPN
biomedich-396	298	24	,	,	PUNCT
biomedich-396	298	25	.	.	PUNCT
biomedich-396	298	26	.	.	PUNCT
biomedich-396	298	27	.	.	PUNCT
biomedich-396	299	1	feng	feng	PROPN
biomedich-396	299	2	,	,	PUNCT
biomedich-396	299	3	w.	w.	PROPN
biomedich-396	299	4	(	(	PUNCT
biomedich-396	299	5	2019	2019	NUM
biomedich-396	299	6	)	)	PUNCT
biomedich-396	299	7	.	.	PUNCT
biomedich-396	300	1	protopine	protopine	PROPN
biomedich-396	300	2	protects	protect	VERB
biomedich-396	300	3	mice	mouse	NOUN
biomedich-396	300	4	against	against	ADP
biomedich-396	300	5	lps	lps	PROPN
biomedich-396	300	6	-	-	PUNCT
biomedich-396	300	7	induced	induce	VERB
biomedich-396	300	8	acute	acute	NOUN
biomedich-396	300	9	kidney	kidney	NOUN
biomedich-396	300	10	injury	injury	NOUN
biomedich-396	300	11	by	by	ADP
biomedich-396	300	12	inhibiting	inhibit	VERB
biomedich-396	300	13	apoptosis	apoptosis	NOUN
biomedich-396	300	14	and	and	CCONJ
biomedich-396	300	15	inflammation	inflammation	NOUN
biomedich-396	300	16	via	via	ADP
biomedich-396	300	17	the	the	DET
biomedich-396	300	18	tlr4	tlr4	NOUN
biomedich-396	300	19	signaling	signal	VERB
biomedich-396	300	20	pathway	pathway	NOUN
biomedich-396	300	21	.	.	PUNCT
biomedich-396	301	1	molecules	molecule	NOUN
biomedich-396	301	2	,	,	PUNCT
biomedich-396	301	3	25(1	25(1	NUM
biomedich-396	301	4	)	)	PUNCT
biomedich-396	301	5	,	,	PUNCT
biomedich-396	301	6	15	15	NUM
biomedich-396	301	7	.	.	PUNCT