id	sid	tid	token	lemma	pos
biomedich-399	1	1	biology	biology	NOUN
biomedich-399	1	2	,	,	PUNCT
biomedich-399	1	3	medicine	medicine	NOUN
biomedich-399	1	4	,	,	PUNCT
biomedich-399	1	5	&	&	CCONJ
biomedich-399	1	6	natural	natural	ADJ
biomedich-399	1	7	product	product	NOUN
biomedich-399	1	8	chemistry	chemistry	NOUN
biomedich-399	1	9	issn	issn	VERB
biomedich-399	1	10	2089	2089	NUM
biomedich-399	1	11	-	-	SYM
biomedich-399	1	12	6514	6514	NUM
biomedich-399	1	13	(	(	PUNCT
biomedich-399	1	14	paper	paper	NOUN
biomedich-399	1	15	)	)	PUNCT
biomedich-399	1	16	volume	volume	NOUN
biomedich-399	1	17	12	12	NUM
biomedich-399	1	18	,	,	PUNCT
biomedich-399	1	19	number	number	NOUN
biomedich-399	1	20	2	2	NUM
biomedich-399	1	21	,	,	PUNCT
biomedich-399	1	22	october	october	PROPN
biomedich-399	1	23	2023	2023	NUM
biomedich-399	2	1	|	|	NOUN
biomedich-399	2	2	pages	page	NOUN
biomedich-399	2	3	:	:	PUNCT
biomedich-399	2	4	585	585	NUM
biomedich-399	2	5	-	-	SYM
biomedich-399	2	6	592	592	NUM
biomedich-399	2	7	|	|	ADV
biomedich-399	2	8	doi	doi	NOUN
biomedich-399	2	9	:	:	PUNCT
biomedich-399	2	10	10.14421	10.14421	NUM
biomedich-399	2	11	/	/	SYM
biomedich-399	2	12	biomedich.2023.122.585	biomedich.2023.122.585	NOUN
biomedich-399	2	13	-	-	SYM
biomedich-399	2	14	592	592	NUM
biomedich-399	2	15	issn	issn	NOUN
biomedich-399	2	16	2540	2540	NUM
biomedich-399	2	17	-	-	SYM
biomedich-399	2	18	9328	9328	NUM
biomedich-399	2	19	(	(	PUNCT
biomedich-399	2	20	online	online	ADV
biomedich-399	2	21	)	)	PUNCT
biomedich-399	2	22	in	in	ADP
biomedich-399	2	23	silico	silico	NOUN
biomedich-399	2	24	study	study	NOUN
biomedich-399	2	25	on	on	ADP
biomedich-399	2	26	structural	structural	ADJ
biomedich-399	2	27	inhibition	inhibition	NOUN
biomedich-399	2	28	of	of	ADP
biomedich-399	2	29	bacterial	bacterial	ADJ
biomedich-399	2	30	dna	dna	NOUN
biomedich-399	2	31	gyrase	gyrase	NOUN
biomedich-399	2	32	by	by	ADP
biomedich-399	2	33	major	major	ADJ
biomedich-399	2	34	secondary	secondary	ADJ
biomedich-399	2	35	metabolites	metabolite	NOUN
biomedich-399	2	36	found	find	VERB
biomedich-399	2	37	in	in	ADP
biomedich-399	2	38	grape	grape	NOUN
biomedich-399	2	39	seed	seed	NOUN
biomedich-399	2	40	extract	extract	NOUN
biomedich-399	2	41	haritha	haritha	PROPN
biomedich-399	2	42	lawan	lawan	PROPN
biomedich-399	2	43	*	*	NUM
biomedich-399	2	44	,	,	PUNCT
biomedich-399	2	45	hashitha	hashitha	PROPN
biomedich-399	2	46	tharakee	tharakee	PROPN
biomedich-399	2	47	department	department	NOUN
biomedich-399	2	48	of	of	ADP
biomedich-399	2	49	chemistry	chemistry	NOUN
biomedich-399	2	50	,	,	PUNCT
biomedich-399	2	51	university	university	NOUN
biomedich-399	2	52	of	of	ADP
biomedich-399	2	53	kelaniya	kelaniya	PROPN
biomedich-399	2	54	,	,	PUNCT
biomedich-399	2	55	sri	sri	PROPN
biomedich-399	2	56	lanka	lanka	PROPN
biomedich-399	2	57	.	.	PUNCT
biomedich-399	3	1	corresponding	correspond	VERB
biomedich-399	3	2	author	author	NOUN
biomedich-399	3	3	*	*	PUNCT
biomedich-399	3	4	harithajayasinghe01@gmail.com	harithajayasinghe01@gmail.com	X
biomedich-399	3	5	manuscript	manuscript	NOUN
biomedich-399	3	6	received	receive	VERB
biomedich-399	3	7	:	:	PUNCT
biomedich-399	3	8	27	27	NUM
biomedich-399	3	9	july	july	NOUN
biomedich-399	3	10	,	,	PUNCT
biomedich-399	3	11	2023	2023	NUM
biomedich-399	3	12	.	.	PUNCT
biomedich-399	4	1	revision	revision	NOUN
biomedich-399	4	2	accepted	accept	VERB
biomedich-399	4	3	:	:	PUNCT
biomedich-399	4	4	25	25	NUM
biomedich-399	4	5	september	september	PROPN
biomedich-399	4	6	,	,	PUNCT
biomedich-399	4	7	2023	2023	NUM
biomedich-399	4	8	.	.	PUNCT
biomedich-399	5	1	published	publish	VERB
biomedich-399	5	2	:	:	PUNCT
biomedich-399	5	3	07	07	NUM
biomedich-399	5	4	november	november	PROPN
biomedich-399	5	5	,	,	PUNCT
biomedich-399	5	6	2023	2023	NUM
biomedich-399	5	7	.	.	PUNCT
biomedich-399	6	1	abstract	abstract	ADJ
biomedich-399	6	2	in	in	ADP
biomedich-399	6	3	the	the	DET
biomedich-399	6	4	early	early	ADJ
biomedich-399	6	5	20th	20th	ADJ
biomedich-399	6	6	century	century	NOUN
biomedich-399	6	7	,	,	PUNCT
biomedich-399	6	8	during	during	ADP
biomedich-399	6	9	the	the	DET
biomedich-399	6	10	era	era	NOUN
biomedich-399	6	11	of	of	ADP
biomedich-399	6	12	investigating	investigate	VERB
biomedich-399	6	13	and	and	CCONJ
biomedich-399	6	14	identifying	identify	VERB
biomedich-399	6	15	essential	essential	ADJ
biomedich-399	6	16	“	"	PUNCT
biomedich-399	6	17	vitamins	vitamin	NOUN
biomedich-399	6	18	”	"	PUNCT
biomedich-399	6	19	,	,	PUNCT
biomedich-399	6	20	scientific	scientific	ADJ
biomedich-399	6	21	research	research	NOUN
biomedich-399	6	22	focused	focus	VERB
biomedich-399	6	23	on	on	ADP
biomedich-399	6	24	grape	grape	NOUN
biomedich-399	6	25	seed	seed	NOUN
biomedich-399	6	26	extracts	extract	NOUN
biomedich-399	6	27	and	and	CCONJ
biomedich-399	6	28	their	their	PRON
biomedich-399	6	29	bioactive	bioactive	ADJ
biomedich-399	6	30	components	component	NOUN
biomedich-399	6	31	,	,	PUNCT
biomedich-399	6	32	particularly	particularly	ADV
biomedich-399	6	33	polyphenols	polyphenol	NOUN
biomedich-399	6	34	.	.	PUNCT
biomedich-399	7	1	extensive	extensive	ADJ
biomedich-399	7	2	studies	study	NOUN
biomedich-399	7	3	have	have	AUX
biomedich-399	7	4	demonstrated	demonstrate	VERB
biomedich-399	7	5	that	that	SCONJ
biomedich-399	7	6	grape	grape	NOUN
biomedich-399	7	7	seed	seed	NOUN
biomedich-399	7	8	extract	extract	NOUN
biomedich-399	7	9	,	,	PUNCT
biomedich-399	7	10	rich	rich	ADJ
biomedich-399	7	11	in	in	ADP
biomedich-399	7	12	proanthocyanidins	proanthocyanidin	NOUN
biomedich-399	7	13	,	,	PUNCT
biomedich-399	7	14	offers	offer	VERB
biomedich-399	7	15	protection	protection	NOUN
biomedich-399	7	16	against	against	ADP
biomedich-399	7	17	a	a	DET
biomedich-399	7	18	wide	wide	ADJ
biomedich-399	7	19	spectrum	spectrum	NOUN
biomedich-399	7	20	of	of	ADP
biomedich-399	7	21	diseases	disease	NOUN
biomedich-399	7	22	,	,	PUNCT
biomedich-399	7	23	encompassing	encompass	VERB
biomedich-399	7	24	inflammation	inflammation	NOUN
biomedich-399	7	25	,	,	PUNCT
biomedich-399	7	26	cardiac	cardiac	ADJ
biomedich-399	7	27	ailments	ailment	NOUN
biomedich-399	7	28	,	,	PUNCT
biomedich-399	7	29	peptic	peptic	ADJ
biomedich-399	7	30	ulcers	ulcer	NOUN
biomedich-399	7	31	,	,	PUNCT
biomedich-399	7	32	hypertension	hypertension	NOUN
biomedich-399	7	33	,	,	PUNCT
biomedich-399	7	34	diabetes	diabetes	NOUN
biomedich-399	7	35	,	,	PUNCT
biomedich-399	7	36	cancer	cancer	NOUN
biomedich-399	7	37	,	,	PUNCT
biomedich-399	7	38	and	and	CCONJ
biomedich-399	7	39	microbial	microbial	ADJ
biomedich-399	7	40	infections	infection	NOUN
biomedich-399	7	41	.	.	PUNCT
biomedich-399	8	1	to	to	PART
biomedich-399	8	2	explore	explore	VERB
biomedich-399	8	3	potential	potential	ADJ
biomedich-399	8	4	secondary	secondary	ADJ
biomedich-399	8	5	metabolites	metabolite	NOUN
biomedich-399	8	6	within	within	ADP
biomedich-399	8	7	grape	grape	NOUN
biomedich-399	8	8	seed	seed	NOUN
biomedich-399	8	9	extract	extract	NOUN
biomedich-399	8	10	that	that	PRON
biomedich-399	8	11	could	could	AUX
biomedich-399	8	12	serve	serve	VERB
biomedich-399	8	13	as	as	ADP
biomedich-399	8	14	structural	structural	ADJ
biomedich-399	8	15	inhibitors	inhibitor	NOUN
biomedich-399	8	16	of	of	ADP
biomedich-399	8	17	bacterial	bacterial	ADJ
biomedich-399	8	18	dna	dna	PROPN
biomedich-399	8	19	gyrase	gyrase	NOUN
biomedich-399	8	20	,	,	PUNCT
biomedich-399	8	21	molecular	molecular	ADJ
biomedich-399	8	22	docking	docking	NOUN
biomedich-399	8	23	studies	study	NOUN
biomedich-399	8	24	were	be	AUX
biomedich-399	8	25	performed	perform	VERB
biomedich-399	8	26	.	.	PUNCT
biomedich-399	9	1	the	the	DET
biomedich-399	9	2	docking	docking	NOUN
biomedich-399	9	3	results	result	NOUN
biomedich-399	9	4	revealed	reveal	VERB
biomedich-399	9	5	that	that	SCONJ
biomedich-399	9	6	two	two	NUM
biomedich-399	9	7	phytochemicals	phytochemical	NOUN
biomedich-399	9	8	,	,	PUNCT
biomedich-399	9	9	namely	namely	ADV
biomedich-399	9	10	(	(	PUNCT
biomedich-399	9	11	-)-catechin	-)-catechin	ADJ
biomedich-399	9	12	and	and	CCONJ
biomedich-399	9	13	procyanidin	procyanidin	NOUN
biomedich-399	9	14	-	-	PUNCT
biomedich-399	9	15	b2	b2	NOUN
biomedich-399	9	16	,	,	PUNCT
biomedich-399	9	17	exhibited	exhibit	VERB
biomedich-399	9	18	the	the	DET
biomedich-399	9	19	highest	high	ADJ
biomedich-399	9	20	potency	potency	NOUN
biomedich-399	9	21	in	in	ADP
biomedich-399	9	22	inhibiting	inhibit	VERB
biomedich-399	9	23	dna	dna	NOUN
biomedich-399	9	24	gyrase	gyrase	NOUN
biomedich-399	9	25	subunit	subunit	NOUN
biomedich-399	9	26	b.	b.	PROPN
biomedich-399	9	27	subsequent	subsequent	ADJ
biomedich-399	9	28	in	in	ADP
biomedich-399	9	29	silico	silico	NOUN
biomedich-399	9	30	physicochemical	physicochemical	ADJ
biomedich-399	9	31	and	and	CCONJ
biomedich-399	9	32	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	9	33	parameter	parameter	NOUN
biomedich-399	9	34	predictions	prediction	NOUN
biomedich-399	9	35	were	be	AUX
biomedich-399	9	36	conducted	conduct	VERB
biomedich-399	9	37	using	use	VERB
biomedich-399	9	38	specialized	specialized	ADJ
biomedich-399	9	39	web	web	NOUN
biomedich-399	9	40	servers	server	NOUN
biomedich-399	9	41	for	for	ADP
biomedich-399	9	42	the	the	DET
biomedich-399	9	43	examined	examine	VERB
biomedich-399	9	44	phytochemicals	phytochemical	NOUN
biomedich-399	9	45	.	.	PUNCT
biomedich-399	10	1	notably	notably	ADV
biomedich-399	10	2	,	,	PUNCT
biomedich-399	10	3	(	(	PUNCT
biomedich-399	10	4	-)-catechin	-)-catechin	X
biomedich-399	10	5	displayed	display	VERB
biomedich-399	10	6	superior	superior	ADJ
biomedich-399	10	7	inhibitory	inhibitory	NOUN
biomedich-399	10	8	and	and	CCONJ
biomedich-399	10	9	admet	admet	PROPN
biomedich-399	10	10	(	(	PUNCT
biomedich-399	10	11	absorption	absorption	NOUN
biomedich-399	10	12	,	,	PUNCT
biomedich-399	10	13	distribution	distribution	NOUN
biomedich-399	10	14	,	,	PUNCT
biomedich-399	10	15	metabolism	metabolism	NOUN
biomedich-399	10	16	,	,	PUNCT
biomedich-399	10	17	excretion	excretion	NOUN
biomedich-399	10	18	,	,	PUNCT
biomedich-399	10	19	and	and	CCONJ
biomedich-399	10	20	toxicity	toxicity	NOUN
biomedich-399	10	21	)	)	PUNCT
biomedich-399	10	22	characteristics	characteristic	NOUN
biomedich-399	10	23	,	,	PUNCT
biomedich-399	10	24	suggesting	suggest	VERB
biomedich-399	10	25	its	its	PRON
biomedich-399	10	26	potential	potential	NOUN
biomedich-399	10	27	for	for	ADP
biomedich-399	10	28	utilization	utilization	NOUN
biomedich-399	10	29	in	in	ADP
biomedich-399	10	30	synthesizing	synthesize	VERB
biomedich-399	10	31	novel	novel	ADJ
biomedich-399	10	32	antibacterial	antibacterial	ADJ
biomedich-399	10	33	compounds	compound	NOUN
biomedich-399	10	34	.	.	PUNCT
biomedich-399	11	1	keywords	keyword	NOUN
biomedich-399	11	2	:	:	PUNCT
biomedich-399	11	3	grape	grape	NOUN
biomedich-399	11	4	seed	seed	NOUN
biomedich-399	11	5	extract	extract	NOUN
biomedich-399	11	6	;	;	PUNCT
biomedich-399	11	7	polyphenols	polyphenol	NOUN
biomedich-399	11	8	;	;	PUNCT
biomedich-399	11	9	catechin	catechin	NOUN
biomedich-399	11	10	;	;	PUNCT
biomedich-399	11	11	molecular	molecular	ADJ
biomedich-399	11	12	docking	docking	NOUN
biomedich-399	11	13	;	;	PUNCT
biomedich-399	11	14	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	11	15	;	;	PUNCT
biomedich-399	11	16	physicochemical	physicochemical	ADJ
biomedich-399	11	17	.	.	PUNCT
biomedich-399	11	18	introduction	introduction	NOUN
biomedich-399	11	19	in	in	ADP
biomedich-399	11	20	recent	recent	ADJ
biomedich-399	11	21	years	year	NOUN
biomedich-399	11	22	,	,	PUNCT
biomedich-399	11	23	extract	extract	VERB
biomedich-399	11	24	from	from	ADP
biomedich-399	11	25	grape	grape	NOUN
biomedich-399	11	26	seed	seed	NOUN
biomedich-399	11	27	has	have	AUX
biomedich-399	11	28	grown	grow	VERB
biomedich-399	11	29	in	in	ADP
biomedich-399	11	30	popularity	popularity	NOUN
biomedich-399	11	31	as	as	ADP
biomedich-399	11	32	a	a	DET
biomedich-399	11	33	dietary	dietary	ADJ
biomedich-399	11	34	supplement	supplement	NOUN
biomedich-399	11	35	,	,	PUNCT
biomedich-399	11	36	particularly	particularly	ADV
biomedich-399	11	37	in	in	ADP
biomedich-399	11	38	australia	australia	PROPN
biomedich-399	11	39	,	,	PUNCT
biomedich-399	11	40	korea	korea	PROPN
biomedich-399	11	41	,	,	PUNCT
biomedich-399	11	42	japan	japan	PROPN
biomedich-399	11	43	,	,	PUNCT
biomedich-399	11	44	and	and	CCONJ
biomedich-399	11	45	the	the	DET
biomedich-399	11	46	united	united	PROPN
biomedich-399	11	47	states	states	PROPN
biomedich-399	11	48	(	(	PUNCT
biomedich-399	11	49	yamakoshi	yamakoshi	PROPN
biomedich-399	11	50	et	et	PROPN
biomedich-399	11	51	al	al	PROPN
biomedich-399	11	52	.	.	PROPN
biomedich-399	11	53	,	,	PUNCT
biomedich-399	11	54	2002	2002	NUM
biomedich-399	11	55	)	)	PUNCT
biomedich-399	11	56	.	.	PUNCT
biomedich-399	12	1	this	this	PRON
biomedich-399	12	2	is	be	AUX
biomedich-399	12	3	due	due	ADJ
biomedich-399	12	4	to	to	ADP
biomedich-399	12	5	the	the	DET
biomedich-399	12	6	fact	fact	NOUN
biomedich-399	12	7	that	that	SCONJ
biomedich-399	12	8	grape	grape	NOUN
biomedich-399	12	9	seeds	seed	NOUN
biomedich-399	12	10	are	be	AUX
biomedich-399	12	11	high	high	ADJ
biomedich-399	12	12	in	in	ADP
biomedich-399	12	13	phenolic	phenolic	ADJ
biomedich-399	12	14	compounds	compound	NOUN
biomedich-399	12	15	and	and	CCONJ
biomedich-399	12	16	may	may	AUX
biomedich-399	12	17	benefit	benefit	VERB
biomedich-399	12	18	human	human	ADJ
biomedich-399	12	19	health	health	NOUN
biomedich-399	12	20	in	in	ADP
biomedich-399	12	21	ways	way	NOUN
biomedich-399	12	22	like	like	ADP
biomedich-399	12	23	preventing	prevent	VERB
biomedich-399	12	24	gastric	gastric	ADJ
biomedich-399	12	25	ulcers	ulcer	NOUN
biomedich-399	12	26	(	(	PUNCT
biomedich-399	12	27	kim	kim	PROPN
biomedich-399	12	28	et	et	PROPN
biomedich-399	12	29	al	al	PROPN
biomedich-399	12	30	.	.	PROPN
biomedich-399	12	31	,	,	PUNCT
biomedich-399	12	32	2013	2013	NUM
biomedich-399	12	33	;	;	PUNCT
biomedich-399	12	34	rodríguez	rodríguez	NOUN
biomedich-399	12	35	montealegre	montealegre	NOUN
biomedich-399	12	36	et	et	PROPN
biomedich-399	12	37	al	al	PROPN
biomedich-399	12	38	.	.	PROPN
biomedich-399	12	39	,	,	PUNCT
biomedich-399	12	40	2006	2006	NUM
biomedich-399	12	41	)	)	PUNCT
biomedich-399	12	42	grapevine	grapevine	NOUN
biomedich-399	12	43	seeds	seed	NOUN
biomedich-399	12	44	have	have	VERB
biomedich-399	12	45	a	a	DET
biomedich-399	12	46	high	high	ADJ
biomedich-399	12	47	antioxidant	antioxidant	NOUN
biomedich-399	12	48	capacity	capacity	NOUN
biomedich-399	12	49	;	;	PUNCT
biomedich-399	12	50	as	as	ADP
biomedich-399	12	51	a	a	DET
biomedich-399	12	52	result	result	NOUN
biomedich-399	12	53	,	,	PUNCT
biomedich-399	12	54	they	they	PRON
biomedich-399	12	55	can	can	AUX
biomedich-399	12	56	reduce	reduce	VERB
biomedich-399	12	57	the	the	DET
biomedich-399	12	58	activity	activity	NOUN
biomedich-399	12	59	of	of	ADP
biomedich-399	12	60	antioxidant	antioxidant	ADJ
biomedich-399	12	61	enzymes	enzyme	NOUN
biomedich-399	12	62	,	,	PUNCT
biomedich-399	12	63	protect	protect	VERB
biomedich-399	12	64	cells	cell	NOUN
biomedich-399	12	65	from	from	ADP
biomedich-399	12	66	oxidative	oxidative	ADJ
biomedich-399	12	67	damage	damage	NOUN
biomedich-399	12	68	,	,	PUNCT
biomedich-399	12	69	have	have	VERB
biomedich-399	12	70	antiinflammatory	antiinflammatory	NOUN
biomedich-399	12	71	and	and	CCONJ
biomedich-399	12	72	anti	anti	ADJ
biomedich-399	12	73	-	-	ADJ
biomedich-399	12	74	atherosclerotic	atherosclerotic	ADJ
biomedich-399	12	75	properties	property	NOUN
biomedich-399	12	76	,	,	PUNCT
biomedich-399	12	77	and	and	CCONJ
biomedich-399	12	78	prevent	prevent	VERB
biomedich-399	12	79	certain	certain	ADJ
biomedich-399	12	80	cancers	cancer	NOUN
biomedich-399	12	81	in	in	ADP
biomedich-399	12	82	both	both	DET
biomedich-399	12	83	humans	human	NOUN
biomedich-399	12	84	and	and	CCONJ
biomedich-399	12	85	animals	animal	NOUN
biomedich-399	12	86	(	(	PUNCT
biomedich-399	12	87	melov	melov	ADJ
biomedich-399	12	88	,	,	PUNCT
biomedich-399	12	89	2002	2002	NUM
biomedich-399	12	90	)	)	PUNCT
biomedich-399	12	91	.	.	PUNCT
biomedich-399	13	1	based	base	VERB
biomedich-399	13	2	on	on	ADP
biomedich-399	13	3	promising	promising	ADJ
biomedich-399	13	4	reports	report	NOUN
biomedich-399	13	5	of	of	ADP
biomedich-399	13	6	their	their	PRON
biomedich-399	13	7	antioxidant	antioxidant	ADJ
biomedich-399	13	8	capabilities	capability	NOUN
biomedich-399	13	9	and	and	CCONJ
biomedich-399	13	10	capacity	capacity	NOUN
biomedich-399	13	11	to	to	PART
biomedich-399	13	12	act	act	VERB
biomedich-399	13	13	as	as	ADP
biomedich-399	13	14	free	free	ADJ
biomedich-399	13	15	radical	radical	ADJ
biomedich-399	13	16	scavengers	scavenger	NOUN
biomedich-399	13	17	,	,	PUNCT
biomedich-399	13	18	the	the	DET
biomedich-399	13	19	polyphenols	polyphenol	NOUN
biomedich-399	13	20	and	and	CCONJ
biomedich-399	13	21	flavonoids	flavonoid	NOUN
biomedich-399	13	22	found	find	VERB
biomedich-399	13	23	in	in	ADP
biomedich-399	13	24	the	the	DET
biomedich-399	13	25	grape	grape	NOUN
biomedich-399	13	26	seed	seed	NOUN
biomedich-399	13	27	extract	extract	NOUN
biomedich-399	13	28	have	have	AUX
biomedich-399	13	29	attracted	attract	VERB
biomedich-399	13	30	great	great	ADJ
biomedich-399	13	31	attention	attention	NOUN
biomedich-399	13	32	(	(	PUNCT
biomedich-399	13	33	georgiev	georgiev	NOUN
biomedich-399	13	34	et	et	PROPN
biomedich-399	13	35	al	al	PROPN
biomedich-399	13	36	.	.	PROPN
biomedich-399	13	37	,	,	PUNCT
biomedich-399	13	38	2014	2014	NUM
biomedich-399	13	39	)	)	PUNCT
biomedich-399	13	40	.	.	PUNCT
biomedich-399	14	1	the	the	DET
biomedich-399	14	2	hunt	hunt	NOUN
biomedich-399	14	3	for	for	ADP
biomedich-399	14	4	novel	novel	ADJ
biomedich-399	14	5	medications	medication	NOUN
biomedich-399	14	6	in	in	ADP
biomedich-399	14	7	the	the	DET
biomedich-399	14	8	area	area	NOUN
biomedich-399	14	9	of	of	ADP
biomedich-399	14	10	secondary	secondary	ADJ
biomedich-399	14	11	plant	plant	NOUN
biomedich-399	14	12	metabolites	metabolite	NOUN
biomedich-399	14	13	as	as	ADP
biomedich-399	14	14	compounds	compound	NOUN
biomedich-399	14	15	for	for	ADP
biomedich-399	14	16	curing	cure	VERB
biomedich-399	14	17	civilizational	civilizational	ADJ
biomedich-399	14	18	disorders	disorder	NOUN
biomedich-399	14	19	has	have	AUX
biomedich-399	14	20	recently	recently	ADV
biomedich-399	14	21	been	be	AUX
biomedich-399	14	22	the	the	DET
biomedich-399	14	23	focus	focus	NOUN
biomedich-399	14	24	of	of	ADP
biomedich-399	14	25	pharmaceutical	pharmaceutical	ADJ
biomedich-399	14	26	and	and	CCONJ
biomedich-399	14	27	commercial	commercial	ADJ
biomedich-399	14	28	trends	trend	NOUN
biomedich-399	14	29	.	.	PUNCT
biomedich-399	15	1	the	the	DET
biomedich-399	15	2	grapevine	grapevine	NOUN
biomedich-399	15	3	(	(	PUNCT
biomedich-399	15	4	vitis	vitis	ADJ
biomedich-399	15	5	vinifera	vinifera	NOUN
biomedich-399	15	6	l.	l.	NOUN
biomedich-399	15	7	)	)	PUNCT
biomedich-399	15	8	seed	seed	NOUN
biomedich-399	15	9	's	's	PART
biomedich-399	15	10	matrix	matrix	NOUN
biomedich-399	15	11	contains	contain	VERB
biomedich-399	15	12	significant	significant	ADJ
biomedich-399	15	13	physiologically	physiologically	ADV
biomedich-399	15	14	active	active	ADJ
biomedich-399	15	15	components	component	NOUN
biomedich-399	15	16	that	that	PRON
biomedich-399	15	17	allow	allow	VERB
biomedich-399	15	18	for	for	ADP
biomedich-399	15	19	its	its	PRON
biomedich-399	15	20	application	application	NOUN
biomedich-399	15	21	in	in	ADP
biomedich-399	15	22	medicine	medicine	NOUN
biomedich-399	15	23	(	(	PUNCT
biomedich-399	15	24	sochorova	sochorova	NOUN
biomedich-399	15	25	et	et	PROPN
biomedich-399	15	26	al	al	PROPN
biomedich-399	15	27	.	.	PROPN
biomedich-399	15	28	,	,	PUNCT
biomedich-399	15	29	2020	2020	NUM
biomedich-399	15	30	)	)	PUNCT
biomedich-399	15	31	proanthocyanidins	proanthocyanidin	NOUN
biomedich-399	15	32	and	and	CCONJ
biomedich-399	15	33	catechins	catechin	NOUN
biomedich-399	15	34	are	be	AUX
biomedich-399	15	35	two	two	NUM
biomedich-399	15	36	types	type	NOUN
biomedich-399	15	37	of	of	ADP
biomedich-399	15	38	flavan3	flavan3	NOUN
biomedich-399	15	39	-	-	PUNCT
biomedich-399	15	40	ol	ol	PROPN
biomedich-399	15	41	that	that	PRON
biomedich-399	15	42	are	be	AUX
biomedich-399	15	43	abundant	abundant	ADJ
biomedich-399	15	44	in	in	ADP
biomedich-399	15	45	grape	grape	NOUN
biomedich-399	15	46	seeds	seed	NOUN
biomedich-399	15	47	.	.	PUNCT
biomedich-399	16	1	they	they	PRON
biomedich-399	16	2	have	have	VERB
biomedich-399	16	3	significant	significant	ADJ
biomedich-399	16	4	concentrations	concentration	NOUN
biomedich-399	16	5	of	of	ADP
biomedich-399	16	6	catechin	catechin	NOUN
biomedich-399	16	7	and	and	CCONJ
biomedich-399	16	8	epicatechincontaining	epicatechincontaine	VERB
biomedich-399	16	9	polyphenol	polyphenol	NOUN
biomedich-399	16	10	proanthocyanidins	proanthocyanidin	NOUN
biomedich-399	16	11	,	,	PUNCT
biomedich-399	16	12	which	which	PRON
biomedich-399	16	13	are	be	AUX
biomedich-399	16	14	oligomers	oligomer	NOUN
biomedich-399	16	15	of	of	ADP
biomedich-399	16	16	flavan-3	flavan-3	PROPN
biomedich-399	16	17	-	-	PUNCT
biomedich-399	16	18	ol	ol	ADJ
biomedich-399	16	19	molecules	molecule	NOUN
biomedich-399	16	20	(	(	PUNCT
biomedich-399	16	21	weseler	weseler	NOUN
biomedich-399	16	22	&	&	CCONJ
biomedich-399	16	23	bast	bast	NOUN
biomedich-399	16	24	,	,	PUNCT
biomedich-399	16	25	2017	2017	NUM
biomedich-399	16	26	)	)	PUNCT
biomedich-399	16	27	.	.	PUNCT
biomedich-399	17	1	grape	grape	NOUN
biomedich-399	17	2	seeds	seed	NOUN
biomedich-399	17	3	have	have	AUX
biomedich-399	17	4	demonstrated	demonstrate	VERB
biomedich-399	17	5	potential	potential	ADJ
biomedich-399	17	6	as	as	ADP
biomedich-399	17	7	novel	novel	ADJ
biomedich-399	17	8	microbial	microbial	ADJ
biomedich-399	17	9	agents	agent	NOUN
biomedich-399	17	10	mainly	mainly	ADV
biomedich-399	17	11	due	due	ADP
biomedich-399	17	12	to	to	ADP
biomedich-399	17	13	their	their	PRON
biomedich-399	17	14	abundance	abundance	NOUN
biomedich-399	17	15	of	of	ADP
biomedich-399	17	16	polyphenols	polyphenol	NOUN
biomedich-399	17	17	.	.	PUNCT
biomedich-399	18	1	defatted	defatted	ADJ
biomedich-399	18	2	grape	grape	NOUN
biomedich-399	18	3	seed	seed	NOUN
biomedich-399	18	4	extracts	extract	NOUN
biomedich-399	18	5	were	be	AUX
biomedich-399	18	6	demonstrated	demonstrate	VERB
biomedich-399	18	7	to	to	PART
biomedich-399	18	8	have	have	VERB
biomedich-399	18	9	antibacterial	antibacterial	ADJ
biomedich-399	18	10	action	action	NOUN
biomedich-399	18	11	against	against	ADP
biomedich-399	18	12	bacillus	bacillus	NOUN
biomedich-399	18	13	cereus	cereus	NOUN
biomedich-399	18	14	,	,	PUNCT
biomedich-399	18	15	bacillus	bacillus	NOUN
biomedich-399	18	16	subtilis	subtili	NOUN
biomedich-399	18	17	,	,	PUNCT
biomedich-399	18	18	staphylococcus	staphylococcus	NOUN
biomedich-399	18	19	aureus	aureus	NOUN
biomedich-399	18	20	,	,	PUNCT
biomedich-399	18	21	bacillus	bacillus	NOUN
biomedich-399	18	22	coagulans	coagulan	NOUN
biomedich-399	18	23	,	,	PUNCT
biomedich-399	18	24	escherichia	escherichia	NOUN
biomedich-399	18	25	coli	coli	NOUN
biomedich-399	18	26	,	,	PUNCT
biomedich-399	18	27	and	and	CCONJ
biomedich-399	18	28	pseudomonas	pseudomona	NOUN
biomedich-399	18	29	aeruginosa	aeruginosa	NOUN
biomedich-399	18	30	,	,	PUNCT
biomedich-399	18	31	according	accord	VERB
biomedich-399	18	32	to	to	ADP
biomedich-399	18	33	jayaprakasha	jayaprakasha	PROPN
biomedich-399	18	34	et	et	PROPN
biomedich-399	18	35	al	al	PROPN
biomedich-399	18	36	(	(	PUNCT
biomedich-399	18	37	jayaprakasha	jayaprakasha	PROPN
biomedich-399	18	38	et	et	PROPN
biomedich-399	18	39	al	al	PROPN
biomedich-399	18	40	.	.	PROPN
biomedich-399	18	41	,	,	PUNCT
biomedich-399	18	42	2003	2003	NUM
biomedich-399	18	43	)	)	PUNCT
biomedich-399	18	44	.	.	PUNCT
biomedich-399	19	1	a	a	DET
biomedich-399	19	2	second	second	ADJ
biomedich-399	19	3	study	study	NOUN
biomedich-399	19	4	by	by	ADP
biomedich-399	19	5	brown	brown	PROPN
biomedich-399	19	6	et	et	PROPN
biomedich-399	19	7	al	al	PROPN
biomedich-399	19	8	.	.	PROPN
biomedich-399	19	9	found	find	VERB
biomedich-399	19	10	that	that	SCONJ
biomedich-399	19	11	muscadine	muscadine	NOUN
biomedich-399	19	12	grape	grape	NOUN
biomedich-399	19	13	seed	seed	NOUN
biomedich-399	19	14	extracts	extract	NOUN
biomedich-399	19	15	were	be	AUX
biomedich-399	19	16	efficient	efficient	ADJ
biomedich-399	19	17	in	in	ADP
biomedich-399	19	18	suppressing	suppress	VERB
biomedich-399	19	19	h.	h.	NOUN
biomedich-399	19	20	pylori	pylori	NOUN
biomedich-399	19	21	in	in	ADP
biomedich-399	19	22	vitro	vitro	X
biomedich-399	19	23	(	(	PUNCT
biomedich-399	19	24	brown	brown	PROPN
biomedich-399	19	25	et	et	PROPN
biomedich-399	19	26	al	al	PROPN
biomedich-399	19	27	.	.	PROPN
biomedich-399	19	28	,	,	PUNCT
biomedich-399	19	29	2009	2009	NUM
biomedich-399	19	30	)	)	PUNCT
biomedich-399	19	31	.	.	PUNCT
biomedich-399	20	1	resveratrol	resveratrol	NOUN
biomedich-399	20	2	exhibits	exhibit	VERB
biomedich-399	20	3	antimicrobial	antimicrobial	ADJ
biomedich-399	20	4	activity	activity	NOUN
biomedich-399	20	5	by	by	ADP
biomedich-399	20	6	causing	cause	VERB
biomedich-399	20	7	oxidative	oxidative	ADJ
biomedich-399	20	8	damage	damage	NOUN
biomedich-399	20	9	to	to	ADP
biomedich-399	20	10	bacterial	bacterial	ADJ
biomedich-399	20	11	membranes	membrane	NOUN
biomedich-399	20	12	without	without	ADP
biomedich-399	20	13	harming	harm	VERB
biomedich-399	20	14	host	host	NOUN
biomedich-399	20	15	cells	cell	NOUN
biomedich-399	20	16	,	,	PUNCT
biomedich-399	20	17	particularly	particularly	ADV
biomedich-399	20	18	in	in	ADP
biomedich-399	20	19	e.	e.	PROPN
biomedich-399	20	20	coli	coli	PROPN
biomedich-399	20	21	.	.	PUNCT
biomedich-399	21	1	these	these	DET
biomedich-399	21	2	findings	finding	NOUN
biomedich-399	21	3	provided	provide	VERB
biomedich-399	21	4	insight	insight	NOUN
biomedich-399	21	5	into	into	ADP
biomedich-399	21	6	the	the	DET
biomedich-399	21	7	potential	potential	NOUN
biomedich-399	21	8	of	of	ADP
biomedich-399	21	9	resveratrol	resveratrol	NOUN
biomedich-399	21	10	to	to	PART
biomedich-399	21	11	support	support	VERB
biomedich-399	21	12	conventional	conventional	ADJ
biomedich-399	21	13	treatments	treatment	NOUN
biomedich-399	21	14	when	when	SCONJ
biomedich-399	21	15	antibiotics	antibiotic	NOUN
biomedich-399	21	16	failed	fail	VERB
biomedich-399	21	17	or	or	CCONJ
biomedich-399	21	18	proved	prove	VERB
biomedich-399	21	19	inefficient	inefficient	ADJ
biomedich-399	21	20	(	(	PUNCT
biomedich-399	21	21	subramanian	subramanian	PROPN
biomedich-399	21	22	et	et	PROPN
biomedich-399	21	23	al	al	PROPN
biomedich-399	21	24	.	.	PROPN
biomedich-399	21	25	,	,	PUNCT
biomedich-399	21	26	2014	2014	NUM
biomedich-399	21	27	)	)	PUNCT
biomedich-399	21	28	the	the	DET
biomedich-399	21	29	polymeric	polymeric	ADJ
biomedich-399	21	30	phenolic	phenolic	ADJ
biomedich-399	21	31	fractions	fraction	NOUN
biomedich-399	21	32	of	of	ADP
biomedich-399	21	33	grape	grape	NOUN
biomedich-399	21	34	seed	seed	NOUN
biomedich-399	21	35	extract	extract	NOUN
biomedich-399	21	36	also	also	ADV
biomedich-399	21	37	showed	show	VERB
biomedich-399	21	38	the	the	DET
biomedich-399	21	39	strongest	strong	ADJ
biomedich-399	21	40	specific	specific	ADJ
biomedich-399	21	41	inhibitory	inhibitory	ADJ
biomedich-399	21	42	activity	activity	NOUN
biomedich-399	21	43	for	for	ADP
biomedich-399	21	44	practically	practically	ADV
biomedich-399	21	45	all	all	PRON
biomedich-399	21	46	listeria	listeria	NOUN
biomedich-399	21	47	species	specie	NOUN
biomedich-399	21	48	;	;	PUNCT
biomedich-399	21	49	it	it	PRON
biomedich-399	21	50	has	have	AUX
biomedich-399	21	51	been	be	AUX
biomedich-399	21	52	reported	report	VERB
biomedich-399	21	53	(	(	PUNCT
biomedich-399	21	54	rhodes	rhode	NOUN
biomedich-399	21	55	et	et	PROPN
biomedich-399	21	56	al	al	PROPN
biomedich-399	21	57	.	.	PROPN
biomedich-399	21	58	,	,	PUNCT
biomedich-399	21	59	2006	2006	NUM
biomedich-399	21	60	)	)	PUNCT
biomedich-399	21	61	.	.	PUNCT
biomedich-399	22	1	https://doi.org/10.14421/biomedich.2023.122.585-592	https://doi.org/10.14421/biomedich.2023.122.585-592	PUNCT
biomedich-399	22	2	586	586	NUM
biomedich-399	22	3	biology	biology	NOUN
biomedich-399	22	4	,	,	PUNCT
biomedich-399	22	5	medicine	medicine	NOUN
biomedich-399	22	6	,	,	PUNCT
biomedich-399	22	7	&	&	CCONJ
biomedich-399	22	8	natural	natural	ADJ
biomedich-399	22	9	product	product	NOUN
biomedich-399	22	10	chemistry	chemistry	NOUN
biomedich-399	22	11	12	12	NUM
biomedich-399	22	12	(	(	PUNCT
biomedich-399	22	13	2	2	NUM
biomedich-399	22	14	)	)	PUNCT
biomedich-399	22	15	,	,	PUNCT
biomedich-399	22	16	2023	2023	NUM
biomedich-399	22	17	:	:	PUNCT
biomedich-399	22	18	585	585	NUM
biomedich-399	22	19	-	-	SYM
biomedich-399	22	20	592	592	NUM
biomedich-399	22	21	a	a	DET
biomedich-399	22	22	b	b	NOUN
biomedich-399	22	23	c	c	X
biomedich-399	22	24	figure	figure	NOUN
biomedich-399	22	25	1	1	NUM
biomedich-399	22	26	.	.	PUNCT
biomedich-399	22	27	a.	a.	NOUN
biomedich-399	22	28	cryoem	cryoem	PROPN
biomedich-399	22	29	structure	structure	NOUN
biomedich-399	22	30	of	of	ADP
biomedich-399	22	31	the	the	DET
biomedich-399	22	32	complete	complete	ADJ
biomedich-399	22	33	e.	e.	PROPN
biomedich-399	22	34	coli	coli	PROPN
biomedich-399	22	35	dna	dna	PROPN
biomedich-399	22	36	gyrase	gyrase	NOUN
biomedich-399	22	37	complex	complex	NOUN
biomedich-399	22	38	bound	bind	VERB
biomedich-399	22	39	to	to	ADP
biomedich-399	22	40	a	a	DET
biomedich-399	22	41	130	130	NUM
biomedich-399	22	42	bp	bp	PROPN
biomedich-399	22	43	dna	dna	PROPN
biomedich-399	22	44	duplex	duplex	PROPN
biomedich-399	22	45	pdb	pdb	PROPN
biomedich-399	22	46	doi	doi	PROPN
biomedich-399	22	47	:	:	PUNCT
biomedich-399	22	48	10.2210	10.2210	NUM
biomedich-399	22	49	/	/	SYM
biomedich-399	22	50	pdb6rkw	pdb6rkw	PROPN
biomedich-399	22	51	/	/	SYM
biomedich-399	22	52	pdb	pdb	PROPN
biomedich-399	22	53	b.	b.	PROPN
biomedich-399	22	54	crystal	crystal	PROPN
biomedich-399	22	55	structure	structure	NOUN
biomedich-399	22	56	of	of	ADP
biomedich-399	22	57	e.	e.	PROPN
biomedich-399	22	58	coli	coli	PROPN
biomedich-399	22	59	gyrase	gyrase	NOUN
biomedich-399	22	60	subunit	subunit	NOUN
biomedich-399	22	61	b	b	PROPN
biomedich-399	22	62	c.	c.	PROPN
biomedich-399	22	63	ramachandran	ramachandran	PROPN
biomedich-399	22	64	plot	plot	NOUN
biomedich-399	22	65	of	of	ADP
biomedich-399	22	66	dna	dna	PROPN
biomedich-399	22	67	gyrase	gyrase	NOUN
biomedich-399	22	68	subunit	subunit	NOUN
biomedich-399	22	69	b.	b.	PROPN
biomedich-399	22	70	dna	dna	PROPN
biomedich-399	22	71	gyrase	gyrase	PROPN
biomedich-399	22	72	is	be	AUX
biomedich-399	22	73	a	a	DET
biomedich-399	22	74	type	type	NOUN
biomedich-399	22	75	ii	ii	NOUN
biomedich-399	22	76	topoisomerase	topoisomerase	NOUN
biomedich-399	22	77	that	that	PRON
biomedich-399	22	78	regulates	regulate	VERB
biomedich-399	22	79	the	the	DET
biomedich-399	22	80	topological	topological	ADJ
biomedich-399	22	81	state	state	NOUN
biomedich-399	22	82	of	of	ADP
biomedich-399	22	83	dna	dna	PROPN
biomedich-399	22	84	in	in	ADP
biomedich-399	22	85	cells	cell	NOUN
biomedich-399	22	86	.	.	PUNCT
biomedich-399	23	1	it	it	PRON
biomedich-399	23	2	is	be	AUX
biomedich-399	23	3	made	make	VERB
biomedich-399	23	4	up	up	ADP
biomedich-399	23	5	of	of	ADP
biomedich-399	23	6	the	the	DET
biomedich-399	23	7	subunits	subunit	NOUN
biomedich-399	23	8	gyra	gyra	NOUN
biomedich-399	23	9	and	and	CCONJ
biomedich-399	23	10	gyrb	gyrb	PROPN
biomedich-399	23	11	.	.	PUNCT
biomedich-399	24	1	(	(	PUNCT
biomedich-399	24	2	figure	figure	NOUN
biomedich-399	24	3	01	01	NUM
biomedich-399	24	4	)	)	PUNCT
biomedich-399	24	5	(	(	PUNCT
biomedich-399	24	6	wang	wang	PROPN
biomedich-399	24	7	,	,	PUNCT
biomedich-399	24	8	2009	2009	NUM
biomedich-399	24	9	)	)	PUNCT
biomedich-399	24	10	.	.	PUNCT
biomedich-399	25	1	dna	dna	PROPN
biomedich-399	25	2	supercoiling	supercoiling	PROPN
biomedich-399	25	3	,	,	PUNCT
biomedich-399	25	4	which	which	PRON
biomedich-399	25	5	is	be	AUX
biomedich-399	25	6	necessary	necessary	ADJ
biomedich-399	25	7	to	to	PART
biomedich-399	25	8	maintain	maintain	VERB
biomedich-399	25	9	dna	dna	PROPN
biomedich-399	25	10	topology	topology	NOUN
biomedich-399	25	11	during	during	ADP
biomedich-399	25	12	replication	replication	NOUN
biomedich-399	25	13	,	,	PUNCT
biomedich-399	25	14	is	be	AUX
biomedich-399	25	15	paired	pair	VERB
biomedich-399	25	16	with	with	ADP
biomedich-399	25	17	atp	atp	NOUN
biomedich-399	25	18	hydrolysis	hydrolysis	NOUN
biomedich-399	25	19	by	by	ADP
biomedich-399	25	20	the	the	DET
biomedich-399	25	21	gyrb	gyrb	ADJ
biomedich-399	25	22	subunit	subunit	NOUN
biomedich-399	25	23	via	via	ADP
biomedich-399	25	24	dna	dna	PROPN
biomedich-399	25	25	gyrase	gyrase	NOUN
biomedich-399	25	26	.	.	PUNCT
biomedich-399	26	1	across	across	ADP
biomedich-399	26	2	all	all	DET
biomedich-399	26	3	bacterial	bacterial	ADJ
biomedich-399	26	4	species	specie	NOUN
biomedich-399	26	5	,	,	PUNCT
biomedich-399	26	6	it	it	PRON
biomedich-399	26	7	is	be	AUX
biomedich-399	26	8	a	a	DET
biomedich-399	26	9	crucial	crucial	ADJ
biomedich-399	26	10	enzyme	enzyme	NOUN
biomedich-399	26	11	whose	whose	DET
biomedich-399	26	12	inhibition	inhibition	NOUN
biomedich-399	26	13	causes	cause	VERB
biomedich-399	26	14	a	a	DET
biomedich-399	26	15	disturbance	disturbance	NOUN
biomedich-399	26	16	in	in	ADP
biomedich-399	26	17	dna	dna	PROPN
biomedich-399	26	18	synthesis	synthesis	NOUN
biomedich-399	26	19	and	and	CCONJ
biomedich-399	26	20	,	,	PUNCT
biomedich-399	26	21	ultimately	ultimately	ADV
biomedich-399	26	22	,	,	PUNCT
biomedich-399	26	23	cell	cell	NOUN
biomedich-399	26	24	death	death	NOUN
biomedich-399	26	25	.	.	PUNCT
biomedich-399	27	1	antibacterial	antibacterial	ADJ
biomedich-399	27	2	medications	medication	NOUN
biomedich-399	27	3	have	have	AUX
biomedich-399	27	4	long	long	ADV
biomedich-399	27	5	been	be	AUX
biomedich-399	27	6	known	know	VERB
biomedich-399	27	7	to	to	PART
biomedich-399	27	8	have	have	VERB
biomedich-399	27	9	an	an	DET
biomedich-399	27	10	interest	interest	NOUN
biomedich-399	27	11	in	in	ADP
biomedich-399	27	12	the	the	DET
biomedich-399	27	13	target	target	NOUN
biomedich-399	27	14	dna	dna	NOUN
biomedich-399	27	15	gyrase	gyrase	NOUN
biomedich-399	27	16	(	(	PUNCT
biomedich-399	27	17	maxwell	maxwell	PROPN
biomedich-399	27	18	&	&	CCONJ
biomedich-399	27	19	lawson	lawson	PROPN
biomedich-399	27	20	,	,	PUNCT
biomedich-399	27	21	2003	2003	NUM
biomedich-399	27	22	)	)	PUNCT
biomedich-399	27	23	.	.	PUNCT
biomedich-399	28	1	quinolones	quinolone	NOUN
biomedich-399	28	2	and	and	CCONJ
biomedich-399	28	3	aminocoumarins	aminocoumarin	NOUN
biomedich-399	28	4	are	be	AUX
biomedich-399	28	5	two	two	NUM
biomedich-399	28	6	families	family	NOUN
biomedich-399	28	7	of	of	ADP
biomedich-399	28	8	antibiotics	antibiotic	NOUN
biomedich-399	28	9	that	that	PRON
biomedich-399	28	10	have	have	AUX
biomedich-399	28	11	demonstrated	demonstrate	VERB
biomedich-399	28	12	in	in	ADP
biomedich-399	28	13	clinical	clinical	ADJ
biomedich-399	28	14	studies	study	NOUN
biomedich-399	28	15	that	that	PRON
biomedich-399	28	16	dna	dna	PROPN
biomedich-399	28	17	gyrase	gyrase	NOUN
biomedich-399	28	18	is	be	AUX
biomedich-399	28	19	a	a	DET
biomedich-399	28	20	workable	workable	ADJ
biomedich-399	28	21	target	target	NOUN
biomedich-399	28	22	(	(	PUNCT
biomedich-399	28	23	drlica	drlica	NOUN
biomedich-399	28	24	et	et	PROPN
biomedich-399	28	25	al	al	PROPN
biomedich-399	28	26	.	.	PROPN
biomedich-399	28	27	,	,	PUNCT
biomedich-399	28	28	2008	2008	NUM
biomedich-399	28	29	)	)	PUNCT
biomedich-399	28	30	.	.	PUNCT
biomedich-399	29	1	materials	material	NOUN
biomedich-399	29	2	and	and	CCONJ
biomedich-399	29	3	methods	method	NOUN
biomedich-399	29	4	data	datum	NOUN
biomedich-399	29	5	collection	collection	NOUN
biomedich-399	29	6	and	and	CCONJ
biomedich-399	29	7	ligand	ligand	ADJ
biomedich-399	29	8	preparation	preparation	NOUN
biomedich-399	29	9	a	a	DET
biomedich-399	29	10	literature	literature	NOUN
biomedich-399	29	11	survey	survey	NOUN
biomedich-399	29	12	was	be	AUX
biomedich-399	29	13	done	do	VERB
biomedich-399	29	14	to	to	PART
biomedich-399	29	15	select	select	VERB
biomedich-399	29	16	the	the	DET
biomedich-399	29	17	suitable	suitable	ADJ
biomedich-399	29	18	secondary	secondary	ADJ
biomedich-399	29	19	metabolites	metabolite	NOUN
biomedich-399	29	20	.	.	PUNCT
biomedich-399	30	1	the	the	DET
biomedich-399	30	2	3d	3d	PROPN
biomedich-399	30	3	chemical	chemical	NOUN
biomedich-399	30	4	structures	structure	NOUN
biomedich-399	30	5	of	of	ADP
biomedich-399	30	6	the	the	DET
biomedich-399	30	7	selected	select	VERB
biomedich-399	30	8	secondary	secondary	ADJ
biomedich-399	30	9	molecules	molecule	NOUN
biomedich-399	30	10	were	be	AUX
biomedich-399	30	11	retrieved	retrieve	VERB
biomedich-399	30	12	from	from	ADP
biomedich-399	30	13	pubchem	pubchem	NOUN
biomedich-399	30	14	database	database	NOUN
biomedich-399	30	15	(	(	PUNCT
biomedich-399	30	16	pubchem	pubchem	NOUN
biomedich-399	30	17	(	(	PUNCT
biomedich-399	30	18	nih.gov	nih.gov	NOUN
biomedich-399	30	19	)	)	PUNCT
biomedich-399	30	20	)	)	PUNCT
biomedich-399	30	21	in	in	ADP
biomedich-399	30	22	.sdf	.sdf	PROPN
biomedich-399	30	23	format	format	NOUN
biomedich-399	30	24	.	.	PUNCT
biomedich-399	31	1	they	they	PRON
biomedich-399	31	2	were	be	AUX
biomedich-399	31	3	imported	import	VERB
biomedich-399	31	4	into	into	ADP
biomedich-399	31	5	avogadro	avogadro	PRON
biomedich-399	31	6	v.1.2.0	v.1.2.0	PROPN
biomedich-399	31	7	software	software	NOUN
biomedich-399	31	8	and	and	CCONJ
biomedich-399	31	9	adjusted	adjust	VERB
biomedich-399	31	10	to	to	ADP
biomedich-399	31	11	physiological	physiological	ADJ
biomedich-399	31	12	protonation	protonation	NOUN
biomedich-399	31	13	states	state	NOUN
biomedich-399	31	14	followed	follow	VERB
biomedich-399	31	15	by	by	ADP
biomedich-399	31	16	energy	energy	NOUN
biomedich-399	31	17	minimization	minimization	NOUN
biomedich-399	31	18	in	in	ADP
biomedich-399	31	19	the	the	DET
biomedich-399	31	20	universal	universal	ADJ
biomedich-399	31	21	force	force	NOUN
biomedich-399	31	22	field	field	NOUN
biomedich-399	31	23	(	(	PUNCT
biomedich-399	31	24	conjugate	conjugate	ADJ
biomedich-399	31	25	gradient	gradient	ADJ
biomedich-399	31	26	algorithm	algorithm	NOUN
biomedich-399	31	27	for	for	ADP
biomedich-399	31	28	500	500	NUM
biomedich-399	31	29	steps	step	NOUN
biomedich-399	31	30	)	)	PUNCT
biomedich-399	31	31	.	.	PUNCT
biomedich-399	32	1	prepared	prepared	ADJ
biomedich-399	32	2	ligands	ligand	NOUN
biomedich-399	32	3	were	be	AUX
biomedich-399	32	4	saved	save	VERB
biomedich-399	32	5	in	in	ADP
biomedich-399	32	6	pdbqt	pdbqt	ADJ
biomedich-399	32	7	format	format	NOUN
biomedich-399	32	8	.	.	PUNCT
biomedich-399	33	1	openbablegui	openbablegui	NOUN
biomedich-399	33	2	is	be	AUX
biomedich-399	33	3	used	use	VERB
biomedich-399	33	4	for	for	ADP
biomedich-399	33	5	extension	extension	NOUN
biomedich-399	33	6	conversation	conversation	NOUN
biomedich-399	33	7	.	.	PUNCT
biomedich-399	34	1	protein	protein	NOUN
biomedich-399	34	2	preparations	preparation	NOUN
biomedich-399	34	3	crystal	crystal	NOUN
biomedich-399	34	4	structure	structure	NOUN
biomedich-399	34	5	of	of	ADP
biomedich-399	34	6	e.	e.	PROPN
biomedich-399	34	7	coli	coli	PROPN
biomedich-399	34	8	gyraseb	gyraseb	NOUN
biomedich-399	34	9	(	(	PUNCT
biomedich-399	34	10	24kda	24kda	NOUN
biomedich-399	34	11	)	)	PUNCT
biomedich-399	34	12	–	–	PUNCT
biomedich-399	35	1	pdb	pdb	PROPN
biomedich-399	35	2	id6f86	id6f86	PROPN
biomedich-399	35	3	were	be	AUX
biomedich-399	35	4	obtained	obtain	VERB
biomedich-399	35	5	from	from	ADP
biomedich-399	35	6	protein	protein	NOUN
biomedich-399	35	7	data	datum	NOUN
biomedich-399	35	8	bank	bank	NOUN
biomedich-399	35	9	in	in	ADP
biomedich-399	35	10	.pdb	.pdb	PROPN
biomedich-399	35	11	format	format	NOUN
biomedich-399	35	12	.	.	PUNCT
biomedich-399	36	1	protein	protein	NOUN
biomedich-399	36	2	preparation	preparation	NOUN
biomedich-399	36	3	was	be	AUX
biomedich-399	36	4	done	do	VERB
biomedich-399	36	5	using	use	VERB
biomedich-399	36	6	autodocktools	autodocktool	NOUN
biomedich-399	36	7	version	version	NOUN
biomedich-399	36	8	1.5.6	1.5.6	NUM
biomedich-399	36	9	.	.	PUNCT
biomedich-399	37	1	the	the	DET
biomedich-399	37	2	water	water	NOUN
biomedich-399	37	3	molecules	molecule	NOUN
biomedich-399	37	4	and	and	CCONJ
biomedich-399	37	5	heteroatoms	heteroatom	NOUN
biomedich-399	37	6	(	(	PUNCT
biomedich-399	37	7	cww	cww	NOUN
biomedich-399	37	8	)	)	PUNCT
biomedich-399	37	9	were	be	AUX
biomedich-399	37	10	deleted	delete	VERB
biomedich-399	37	11	.	.	PUNCT
biomedich-399	38	1	missing	miss	VERB
biomedich-399	38	2	atoms	atom	NOUN
biomedich-399	38	3	were	be	AUX
biomedich-399	38	4	repaired	repair	VERB
biomedich-399	38	5	.	.	PUNCT
biomedich-399	39	1	polar	polar	ADJ
biomedich-399	39	2	hydrogens	hydrogen	NOUN
biomedich-399	39	3	and	and	CCONJ
biomedich-399	39	4	kollman	kollman	NOUN
biomedich-399	39	5	charges	charge	NOUN
biomedich-399	39	6	were	be	AUX
biomedich-399	39	7	added	add	VERB
biomedich-399	39	8	to	to	ADP
biomedich-399	39	9	the	the	DET
biomedich-399	39	10	protein	protein	NOUN
biomedich-399	39	11	.	.	PUNCT
biomedich-399	40	1	molecular	molecular	ADJ
biomedich-399	40	2	docking	dock	VERB
biomedich-399	40	3	the	the	DET
biomedich-399	40	4	grid	grid	NOUN
biomedich-399	40	5	parameters	parameter	NOUN
biomedich-399	40	6	and	and	CCONJ
biomedich-399	40	7	map	map	VERB
biomedich-399	40	8	files	file	NOUN
biomedich-399	40	9	were	be	AUX
biomedich-399	40	10	created	create	VERB
biomedich-399	40	11	using	use	VERB
biomedich-399	40	12	autogrid	autogrid	ADJ
biomedich-399	40	13	4.2	4.2	NUM
biomedich-399	40	14	.	.	PUNCT
biomedich-399	41	1	to	to	PART
biomedich-399	41	2	perform	perform	VERB
biomedich-399	41	3	the	the	DET
biomedich-399	41	4	blind	blind	ADJ
biomedich-399	41	5	docking	docking	NOUN
biomedich-399	41	6	.	.	PUNCT
biomedich-399	42	1	(	(	PUNCT
biomedich-399	42	2	genetic	genetic	ADJ
biomedich-399	42	3	algorithm	algorithm	NOUN
biomedich-399	42	4	parameters	parameter	NOUN
biomedich-399	42	5	settings	setting	NOUN
biomedich-399	42	6	:	:	PUNCT
biomedich-399	42	7	number	number	NOUN
biomedich-399	42	8	of	of	ADP
biomedich-399	42	9	genetic	genetic	ADJ
biomedich-399	42	10	algorithm	algorithm	NOUN
biomedich-399	42	11	(	(	PUNCT
biomedich-399	42	12	ga	ga	NOUN
biomedich-399	42	13	)	)	PUNCT
biomedich-399	42	14	runs	run	NOUN
biomedich-399	42	15	:	:	PUNCT
biomedich-399	42	16	50	50	NUM
biomedich-399	42	17	,	,	PUNCT
biomedich-399	42	18	population	population	NOUN
biomedich-399	42	19	size	size	NOUN
biomedich-399	42	20	:	:	PUNCT
biomedich-399	42	21	300	300	NUM
biomedich-399	42	22	,	,	PUNCT
biomedich-399	42	23	the	the	DET
biomedich-399	42	24	maximum	maximum	ADJ
biomedich-399	42	25	number	number	NOUN
biomedich-399	42	26	of	of	ADP
biomedich-399	42	27	evaluations	evaluation	NOUN
biomedich-399	42	28	:	:	PUNCT
biomedich-399	42	29	25	25	NUM
biomedich-399	42	30	000	000	NUM
biomedich-399	42	31	000	000	NUM
biomedich-399	42	32	(	(	PUNCT
biomedich-399	42	33	medium	medium	NOUN
biomedich-399	42	34	)	)	PUNCT
biomedich-399	42	35	,	,	PUNCT
biomedich-399	42	36	and	and	CCONJ
biomedich-399	42	37	maximum	maximum	ADJ
biomedich-399	42	38	number	number	NOUN
biomedich-399	42	39	of	of	ADP
biomedich-399	42	40	generations	generation	NOUN
biomedich-399	42	41	:	:	PUNCT
biomedich-399	42	42	27	27	NUM
biomedich-399	42	43	000	000	NUM
biomedich-399	42	44	)	)	PUNCT
biomedich-399	42	45	.	.	PUNCT
biomedich-399	43	1	molecular	molecular	ADJ
biomedich-399	43	2	docking	docking	NOUN
biomedich-399	43	3	was	be	AUX
biomedich-399	43	4	performed	perform	VERB
biomedich-399	43	5	using	use	VERB
biomedich-399	43	6	autodock	autodock	NOUN
biomedich-399	43	7	4.2	4.2	NUM
biomedich-399	43	8	,	,	PUNCT
biomedich-399	43	9	and	and	CCONJ
biomedich-399	43	10	results	result	NOUN
biomedich-399	43	11	were	be	AUX
biomedich-399	43	12	generated	generate	VERB
biomedich-399	43	13	in	in	ADP
biomedich-399	43	14	.dlg	.dlg	PROPN
biomedich-399	43	15	format	format	NOUN
biomedich-399	43	16	(	(	PUNCT
biomedich-399	43	17	output	output	NOUN
biomedich-399	43	18	–	–	PUNCT
biomedich-399	43	19	lamarckian	lamarckian	ADJ
biomedich-399	43	20	ga-4.2	ga-4.2	NOUN
biomedich-399	43	21	)	)	PUNCT
biomedich-399	43	22	.	.	PUNCT
biomedich-399	44	1	interaction	interaction	NOUN
biomedich-399	44	2	visualization	visualization	NOUN
biomedich-399	44	3	and	and	CCONJ
biomedich-399	44	4	analysis	analysis	NOUN
biomedich-399	44	5	docking	docking	NOUN
biomedich-399	44	6	results	result	NOUN
biomedich-399	44	7	were	be	AUX
biomedich-399	44	8	analyzed	analyze	VERB
biomedich-399	44	9	using	use	VERB
biomedich-399	44	10	autodocktools	autodocktool	NOUN
biomedich-399	44	11	version	version	NOUN
biomedich-399	44	12	1.5.6	1.5.6	NUM
biomedich-399	44	13	to	to	PART
biomedich-399	44	14	examine	examine	VERB
biomedich-399	44	15	the	the	DET
biomedich-399	44	16	binding	bind	VERB
biomedich-399	44	17	energies	energy	NOUN
biomedich-399	44	18	and	and	CCONJ
biomedich-399	44	19	inhibition	inhibition	NOUN
biomedich-399	44	20	constants	constant	NOUN
biomedich-399	44	21	.	.	PUNCT
biomedich-399	45	1	binding	bind	VERB
biomedich-399	45	2	interactions	interaction	NOUN
biomedich-399	45	3	with	with	ADP
biomedich-399	45	4	the	the	DET
biomedich-399	45	5	ligand	ligand	NOUN
biomedich-399	45	6	were	be	AUX
biomedich-399	45	7	visualized	visualize	VERB
biomedich-399	45	8	using	use	VERB
biomedich-399	45	9	ucsf	ucsf	ADJ
biomedich-399	45	10	chimera	chimera	NOUN
biomedich-399	45	11	1.16	1.16	NUM
biomedich-399	45	12	and	and	CCONJ
biomedich-399	45	13	pymol	pymol	PROPN
biomedich-399	45	14	v.2.5.4	v.2.5.4	PROPN
biomedich-399	45	15	.	.	PUNCT
biomedich-399	46	1	protein	protein	NOUN
biomedich-399	46	2	-	-	PUNCT
biomedich-399	46	3	ligand	ligand	NOUN
biomedich-399	46	4	interaction	interaction	NOUN
biomedich-399	46	5	profiler	profiler	NOUN
biomedich-399	46	6	(	(	PUNCT
biomedich-399	46	7	plip	plip	PROPN
biomedich-399	46	8	welcome	welcome	INTJ
biomedich-399	46	9	(	(	PUNCT
biomedich-399	46	10	tu-dresden.de	tu-dresden.de	NUM
biomedich-399	46	11	)	)	PUNCT
biomedich-399	46	12	)	)	PUNCT
biomedich-399	46	13	and	and	CCONJ
biomedich-399	46	14	proteins.plus	proteins.plus	NUM
biomedich-399	46	15	(	(	PUNCT
biomedich-399	46	16	zentrum	zentrum	X
biomedich-399	46	17	für	für	PROPN
biomedich-399	46	18	bioinformatik	bioinformatik	PROPN
biomedich-399	46	19	:	:	PUNCT
biomedich-399	46	20	universität	universität	ADJ
biomedich-399	46	21	hamburg	hamburg	NOUN
biomedich-399	46	22	proteins	protein	NOUN
biomedich-399	46	23	plus	plus	CCONJ
biomedich-399	46	24	server	server	NOUN
biomedich-399	46	25	)	)	PUNCT
biomedich-399	46	26	web	web	NOUN
biomedich-399	46	27	servers	server	NOUN
biomedich-399	46	28	were	be	AUX
biomedich-399	46	29	also	also	ADV
biomedich-399	46	30	used	use	VERB
biomedich-399	46	31	to	to	PART
biomedich-399	46	32	further	far	ADV
biomedich-399	46	33	analyze	analyze	VERB
biomedich-399	46	34	the	the	DET
biomedich-399	46	35	binding	bind	VERB
biomedich-399	46	36	residues	residue	NOUN
biomedich-399	46	37	.	.	PUNCT
biomedich-399	47	1	in	in	ADP
biomedich-399	47	2	silico	silico	NOUN
biomedich-399	47	3	physicochemical	physicochemical	ADJ
biomedich-399	47	4	and	and	CCONJ
biomedich-399	47	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	47	6	parameter	parameter	NOUN
biomedich-399	47	7	prediction	prediction	NOUN
biomedich-399	47	8	veber	veber	PROPN
biomedich-399	47	9	's	's	PART
biomedich-399	47	10	rules	rule	NOUN
biomedich-399	47	11	(	(	PUNCT
biomedich-399	47	12	veber	veber	PROPN
biomedich-399	47	13	et	et	PROPN
biomedich-399	47	14	al	al	PROPN
biomedich-399	47	15	.	.	PROPN
biomedich-399	47	16	,	,	PUNCT
biomedich-399	47	17	2002	2002	NUM
biomedich-399	47	18	)	)	PUNCT
biomedich-399	47	19	and	and	CCONJ
biomedich-399	47	20	lipinski	lipinski	PROPN
biomedich-399	47	21	's	's	PART
biomedich-399	47	22	rule	rule	NOUN
biomedich-399	47	23	of	of	ADP
biomedich-399	47	24	five	five	NUM
biomedich-399	47	25	(	(	PUNCT
biomedich-399	47	26	lipinski	lipinski	PROPN
biomedich-399	47	27	et	et	PROPN
biomedich-399	47	28	al	al	PROPN
biomedich-399	47	29	.	.	PROPN
biomedich-399	47	30	,	,	PUNCT
biomedich-399	47	31	2001	2001	NUM
biomedich-399	47	32	)	)	PUNCT
biomedich-399	47	33	were	be	AUX
biomedich-399	47	34	applied	apply	VERB
biomedich-399	47	35	to	to	PART
biomedich-399	47	36	evaluate	evaluate	VERB
biomedich-399	47	37	druglikeness	druglikeness	NOUN
biomedich-399	47	38	using	use	VERB
biomedich-399	47	39	the	the	DET
biomedich-399	47	40	swissadme	swissadme	PROPN
biomedich-399	47	41	server	server	PROPN
biomedich-399	47	42	(	(	PUNCT
biomedich-399	47	43	swissadme	swissadme	NOUN
biomedich-399	47	44	)	)	PUNCT
biomedich-399	47	45	.	.	PUNCT
biomedich-399	48	1	secondary	secondary	ADJ
biomedich-399	48	2	metabolites	metabolite	NOUN
biomedich-399	48	3	given	give	VERB
biomedich-399	48	4	in	in	ADP
biomedich-399	48	5	table	table	NOUN
biomedich-399	48	6	1	1	NUM
biomedich-399	48	7	were	be	AUX
biomedich-399	48	8	analyzed	analyze	VERB
biomedich-399	48	9	for	for	ADP
biomedich-399	48	10	their	their	PRON
biomedich-399	48	11	physicochemical	physicochemical	ADJ
biomedich-399	48	12	properties	property	NOUN
biomedich-399	48	13	,	,	PUNCT
biomedich-399	48	14	and	and	CCONJ
biomedich-399	48	15	the	the	DET
biomedich-399	48	16	results	result	NOUN
biomedich-399	48	17	are	be	AUX
biomedich-399	48	18	epitomized	epitomize	VERB
biomedich-399	48	19	in	in	ADP
biomedich-399	48	20	table	table	NOUN
biomedich-399	48	21	2	2	NUM
biomedich-399	48	22	.	.	PUNCT
biomedich-399	49	1	the	the	DET
biomedich-399	49	2	admet	admet	PROPN
biomedich-399	49	3	characteristics	characteristic	NOUN
biomedich-399	49	4	of	of	ADP
biomedich-399	49	5	the	the	DET
biomedich-399	49	6	secondary	secondary	ADJ
biomedich-399	49	7	metabolites	metabolite	NOUN
biomedich-399	49	8	were	be	AUX
biomedich-399	49	9	studied	study	VERB
biomedich-399	49	10	using	use	VERB
biomedich-399	49	11	the	the	DET
biomedich-399	49	12	pkcsm	pkcsm	NOUN
biomedich-399	49	13	server	server	NOUN
biomedich-399	49	14	(	(	PUNCT
biomedich-399	49	15	https://biosig.lab.uq.edu.au/pkcsm/	https://biosig.lab.uq.edu.au/pkcsm/	PROPN
biomedich-399	49	16	)	)	PUNCT
biomedich-399	49	17	to	to	PART
biomedich-399	49	18	understand	understand	VERB
biomedich-399	49	19	their	their	PRON
biomedich-399	49	20	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	49	21	parameters	parameter	NOUN
biomedich-399	49	22	,	,	PUNCT
biomedich-399	49	23	and	and	CCONJ
biomedich-399	49	24	the	the	DET
biomedich-399	49	25	results	result	NOUN
biomedich-399	49	26	are	be	AUX
biomedich-399	49	27	given	give	VERB
biomedich-399	49	28	in	in	ADP
biomedich-399	49	29	table	table	NOUN
biomedich-399	49	30	3	3	NUM
biomedich-399	49	31	.	.	PUNCT
biomedich-399	50	1	http://doi.org/10.2210/pdb6rkw/pdb	http://doi.org/10.2210/pdb6rkw/pdb	PROPN
biomedich-399	50	2	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
biomedich-399	50	3	https://plip-tool.biotec.tu-dresden.de/plip-web/plip/index	https://plip-tool.biotec.tu-dresden.de/plip-web/plip/index	NOUN
biomedich-399	50	4	https://plip-tool.biotec.tu-dresden.de/plip-web/plip/index	https://plip-tool.biotec.tu-dresden.de/plip-web/plip/index	NOUN
biomedich-399	50	5	https://proteins.plus/	https://proteins.plus/	PROPN
biomedich-399	51	1	https://proteins.plus/	https://proteins.plus/	PROPN
biomedich-399	51	2	https://proteins.plus/	https://proteins.plus/	PROPN
biomedich-399	51	3	http://www.swissadme.ch/index.php	http://www.swissadme.ch/index.php	INTJ
biomedich-399	51	4	https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/absorption-distribution-metabolism-excretion-toxicity	https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/absorption-distribution-metabolism-excretion-toxicity	NOUN
biomedich-399	51	5	https://biosig.lab.uq.edu.au/pkcsm/	https://biosig.lab.uq.edu.au/pkcsm/	SYM
biomedich-399	51	6	lawan	lawan	PROPN
biomedich-399	51	7	&	&	CCONJ
biomedich-399	51	8	tharakee	tharakee	PROPN
biomedich-399	51	9	–	–	PUNCT
biomedich-399	51	10	dna	dna	NOUN
biomedich-399	51	11	gyrase	gyrase	NOUN
biomedich-399	51	12	inhibition	inhibition	NOUN
biomedich-399	51	13	by	by	ADP
biomedich-399	51	14	grape	grape	NOUN
biomedich-399	51	15	metabolites	metabolite	NOUN
biomedich-399	51	16	587	587	NUM
biomedich-399	51	17	results	result	NOUN
biomedich-399	51	18	and	and	CCONJ
biomedich-399	51	19	discussion	discussion	NOUN
biomedich-399	51	20	table	table	NOUN
biomedich-399	51	21	1	1	NUM
biomedich-399	51	22	.	.	PUNCT
biomedich-399	51	23	calculated	calculate	VERB
biomedich-399	51	24	binding	bind	VERB
biomedich-399	51	25	energies	energy	NOUN
biomedich-399	51	26	and	and	CCONJ
biomedich-399	51	27	inhibition	inhibition	VERB
biomedich-399	51	28	constants	constant	NOUN
biomedich-399	51	29	of	of	ADP
biomedich-399	51	30	a.	a.	PROPN
biomedich-399	51	31	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	51	32	-	-	PUNCT
biomedich-399	51	33	a	a	PROPN
biomedich-399	51	34	and	and	CCONJ
biomedich-399	51	35	b.	b.	NOUN
biomedich-399	51	36	selected	select	VERB
biomedich-399	51	37	phytochemicals	phytochemical	NOUN
biomedich-399	51	38	-	-	PUNCT
biomedich-399	51	39	b.	b.	NOUN
biomedich-399	51	40	a.	a.	NOUN
biomedich-399	51	41	reference	reference	NOUN
biomedich-399	51	42	compound	compound	VERB
biomedich-399	51	43	binding	bind	VERB
biomedich-399	51	44	energy	energy	NOUN
biomedich-399	51	45	/	/	SYM
biomedich-399	51	46	kcal	kcal	PROPN
biomedich-399	51	47	/	/	SYM
biomedich-399	51	48	mol	mol	ADP
biomedich-399	51	49	ki	ki	X
biomedich-399	51	50	-	-	PUNCT
biomedich-399	51	51	inhibition	inhibition	NOUN
biomedich-399	51	52	constant/	constant/	NUM
biomedich-399	51	53	µm	µm	ADP
biomedich-399	51	54	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	51	55	-6.19	-6.19	NUM
biomedich-399	51	56	28.80	28.80	NUM
biomedich-399	51	57	b.	b.	PROPN
biomedich-399	51	58	compound	compound	NOUN
biomedich-399	51	59	binding	bind	VERB
biomedich-399	51	60	energy	energy	NOUN
biomedich-399	51	61	/	/	SYM
biomedich-399	51	62	kcal	kcal	PROPN
biomedich-399	51	63	/	/	SYM
biomedich-399	51	64	mol	mol	ADP
biomedich-399	51	65	ki	ki	PROPN
biomedich-399	51	66	-	-	PUNCT
biomedich-399	51	67	inhibition	inhibition	NOUN
biomedich-399	51	68	constant	constant	ADJ
biomedich-399	51	69	/µm	/µm	PUNCT
biomedich-399	51	70	compound	compound	NOUN
biomedich-399	51	71	binding	bind	VERB
biomedich-399	51	72	energy	energy	NOUN
biomedich-399	51	73	/	/	SYM
biomedich-399	51	74	kcal	kcal	PROPN
biomedich-399	51	75	/	/	SYM
biomedich-399	51	76	mol	mol	ADP
biomedich-399	51	77	ki	ki	PROPN
biomedich-399	51	78	-	-	PUNCT
biomedich-399	51	79	inhibition	inhibition	NOUN
biomedich-399	51	80	constant	constant	ADJ
biomedich-399	51	81	/µm	/µm	PUNCT
biomedich-399	52	1	(	(	PUNCT
biomedich-399	52	2	-)-catechin	-)-catechin	X
biomedich-399	52	3	-6.22	-6.22	NOUN
biomedich-399	52	4	27.52	27.52	NUM
biomedich-399	52	5	epigallocatechin	epigallocatechin	NOUN
biomedich-399	52	6	-5.11	-5.11	NUM
biomedich-399	52	7	180.46	180.46	NUM
biomedich-399	52	8	(	(	PUNCT
biomedich-399	52	9	-)-epicatechin	-)-epicatechin	PROPN
biomedich-399	52	10	-5.32	-5.32	NUM
biomedich-399	52	11	95.83	95.83	NUM
biomedich-399	52	12	procyanidin	procyanidin	NOUN
biomedich-399	52	13	-	-	PUNCT
biomedich-399	52	14	b3	b3	NOUN
biomedich-399	52	15	-5.59	-5.59	NUM
biomedich-399	52	16	80.03	80.03	NUM
biomedich-399	52	17	epicatechin-3	epicatechin-3	PROPN
biomedich-399	52	18	-	-	PUNCT
biomedich-399	52	19	gallate	gallate	NOUN
biomedich-399	52	20	-4.46	-4.46	NOUN
biomedich-399	52	21	540.36	540.36	NUM
biomedich-399	52	22	procyanidin	procyanidin	NOUN
biomedich-399	52	23	-	-	PUNCT
biomedich-399	52	24	b2	b2	NOUN
biomedich-399	52	25	-6.31	-6.31	NUM
biomedich-399	52	26	23.67	23.67	NUM
biomedich-399	52	27	procyanidin	procyanidin	NOUN
biomedich-399	52	28	-	-	PUNCT
biomedich-399	52	29	b1	b1	NOUN
biomedich-399	52	30	-5.05	-5.05	NOUN
biomedich-399	52	31	198.11	198.11	NUM
biomedich-399	52	32	procyanidin	procyanidin	NOUN
biomedich-399	52	33	-	-	PUNCT
biomedich-399	52	34	b4	b4	NOUN
biomedich-399	52	35	-5.60	-5.60	NUM
biomedich-399	52	36	77.90	77.90	NUM
biomedich-399	52	37	(	(	PUNCT
biomedich-399	52	38	+	+	ADJ
biomedich-399	52	39	)	)	PUNCT
biomedich-399	52	40	-gallocatechin	-gallocatechin	NOUN
biomedich-399	52	41	-5.31	-5.31	NUM
biomedich-399	52	42	127.21	127.21	NUM
biomedich-399	52	43	quercetin	quercetin	NOUN
biomedich-399	52	44	-5.36	-5.36	NOUN
biomedich-399	52	45	117.82	117.82	NUM
biomedich-399	52	46	588	588	NUM
biomedich-399	52	47	biology	biology	NOUN
biomedich-399	52	48	,	,	PUNCT
biomedich-399	52	49	medicine	medicine	NOUN
biomedich-399	52	50	,	,	PUNCT
biomedich-399	52	51	&	&	CCONJ
biomedich-399	52	52	natural	natural	ADJ
biomedich-399	52	53	product	product	NOUN
biomedich-399	52	54	chemistry	chemistry	NOUN
biomedich-399	52	55	12	12	NUM
biomedich-399	52	56	(	(	PUNCT
biomedich-399	52	57	2	2	NUM
biomedich-399	52	58	)	)	PUNCT
biomedich-399	52	59	,	,	PUNCT
biomedich-399	52	60	2023	2023	NUM
biomedich-399	52	61	:	:	PUNCT
biomedich-399	52	62	585	585	NUM
biomedich-399	52	63	-	-	SYM
biomedich-399	52	64	592	592	NUM
biomedich-399	52	65	a.	a.	NOUN
biomedich-399	52	66	b.	b.	PROPN
biomedich-399	52	67	c.	c.	PROPN
biomedich-399	52	68	d.	d.	PROPN
biomedich-399	52	69	e.	e.	PROPN
biomedich-399	52	70	f.	f.	PROPN
biomedich-399	52	71	g.	g.	PROPN
biomedich-399	52	72	h.	h.	PROPN
biomedich-399	52	73	i.	i.	PROPN
biomedich-399	52	74	j.	j.	PROPN
biomedich-399	52	75	k.	k.	PROPN
biomedich-399	52	76	figure	figure	PROPN
biomedich-399	52	77	2	2	NUM
biomedich-399	52	78	.	.	PUNCT
biomedich-399	52	79	bonding	bonding	NOUN
biomedich-399	52	80	interaction	interaction	NOUN
biomedich-399	52	81	within	within	ADP
biomedich-399	52	82	the	the	DET
biomedich-399	52	83	binding	bind	VERB
biomedich-399	52	84	pocket	pocket	NOUN
biomedich-399	52	85	of	of	ADP
biomedich-399	52	86	dna	dna	PROPN
biomedich-399	52	87	gyrb	gyrb	ADJ
biomedich-399	52	88	with	with	ADP
biomedich-399	52	89	a.	a.	PROPN
biomedich-399	52	90	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	52	91	b.	b.	PROPN
biomedich-399	53	1	(	(	PUNCT
biomedich-399	53	2	-)-catechin	-)-catechin	PROPN
biomedich-399	53	3	c.	c.	PROPN
biomedich-399	53	4	epicatechin	epicatechin	PROPN
biomedich-399	53	5	d.	d.	PROPN
biomedich-399	53	6	epicatechin	epicatechin	PROPN
biomedich-399	53	7	e.	e.	PROPN
biomedich-399	53	8	procyanidinb1	procyanidinb1	PROPN
biomedich-399	54	1	f.	f.	PROPN
biomedich-399	54	2	(	(	PUNCT
biomedich-399	54	3	+	+	ADJ
biomedich-399	54	4	)	)	PUNCT
biomedich-399	54	5	-gallocatechin	-gallocatechin	PROPN
biomedich-399	54	6	g.	g.	PROPN
biomedich-399	54	7	epigallocatechin	epigallocatechin	PROPN
biomedich-399	54	8	h.	h.	PROPN
biomedich-399	54	9	procyanidin	procyanidin	PROPN
biomedich-399	54	10	-	-	PUNCT
biomedich-399	54	11	b3	b3	PROPN
biomedich-399	54	12	i.	i.	NOUN
biomedich-399	54	13	procyanidin	procyanidin	NOUN
biomedich-399	54	14	-	-	PUNCT
biomedich-399	54	15	b2	b2	NOUN
biomedich-399	54	16	j.	j.	PROPN
biomedich-399	54	17	procyanidin	procyanidin	PROPN
biomedich-399	54	18	-	-	PUNCT
biomedich-399	54	19	b4	b4	PROPN
biomedich-399	54	20	k.	k.	PROPN
biomedich-399	54	21	quercetin	quercetin	PROPN
biomedich-399	54	22	that	that	PRON
biomedich-399	54	23	generated	generate	VERB
biomedich-399	54	24	using	use	VERB
biomedich-399	54	25	protein	protein	NOUN
biomedich-399	54	26	-	-	PUNCT
biomedich-399	54	27	ligand	ligand	NOUN
biomedich-399	54	28	interaction	interaction	NOUN
biomedich-399	54	29	profiler	profiler	NOUN
biomedich-399	54	30	.	.	PUNCT
biomedich-399	55	1	a.	a.	PROPN
biomedich-399	55	2	b.	b.	PROPN
biomedich-399	55	3	c.	c.	PROPN
biomedich-399	55	4	d.	d.	PROPN
biomedich-399	55	5	e.	e.	PROPN
biomedich-399	55	6	f.	f.	PROPN
biomedich-399	55	7	g.	g.	PROPN
biomedich-399	55	8	h.	h.	PROPN
biomedich-399	55	9	i.	i.	PROPN
biomedich-399	55	10	j.	j.	PROPN
biomedich-399	55	11	k.	k.	PROPN
biomedich-399	55	12	figure	figure	VERB
biomedich-399	55	13	3	3	NUM
biomedich-399	55	14	.	.	PUNCT
biomedich-399	55	15	3d	3d	NUM
biomedich-399	55	16	visualization	visualization	NOUN
biomedich-399	55	17	of	of	ADP
biomedich-399	55	18	the	the	DET
biomedich-399	55	19	ligand	ligand	NOUN
biomedich-399	55	20	-	-	PUNCT
biomedich-399	55	21	dna	dna	NOUN
biomedich-399	55	22	gyrb	gyrb	ADJ
biomedich-399	55	23	complexes	complex	NOUN
biomedich-399	55	24	,	,	PUNCT
biomedich-399	55	25	a.	a.	NOUN
biomedich-399	55	26	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	55	27	b.(-)-catechin	b.(-)-catechin	PROPN
biomedich-399	55	28	c.	c.	PROPN
biomedich-399	55	29	epicatechin	epicatechin	PROPN
biomedich-399	55	30	d.	d.	PROPN
biomedich-399	55	31	epicatechin	epicatechin	PROPN
biomedich-399	55	32	e.	e.	PROPN
biomedich-399	55	33	procyanidin	procyanidin	PROPN
biomedich-399	55	34	-	-	PUNCT
biomedich-399	55	35	b1	b1	NOUN
biomedich-399	55	36	f.	f.	PROPN
biomedich-399	55	37	(	(	PUNCT
biomedich-399	55	38	+	+	ADJ
biomedich-399	55	39	)	)	PUNCT
biomedich-399	55	40	gallocatechin	gallocatechin	PROPN
biomedich-399	55	41	g.	g.	PROPN
biomedich-399	55	42	epigallocatechin	epigallocatechin	PROPN
biomedich-399	56	1	h.	h.	PROPN
biomedich-399	56	2	procyanidin	procyanidin	PROPN
biomedich-399	56	3	-	-	PUNCT
biomedich-399	56	4	b3	b3	PROPN
biomedich-399	56	5	i.	i.	NOUN
biomedich-399	56	6	procyanidin	procyanidin	NOUN
biomedich-399	56	7	-	-	PUNCT
biomedich-399	56	8	b2	b2	NOUN
biomedich-399	56	9	j.	j.	PROPN
biomedich-399	56	10	procyanidin	procyanidin	PROPN
biomedich-399	56	11	-	-	PUNCT
biomedich-399	56	12	b4	b4	PROPN
biomedich-399	56	13	k.	k.	PROPN
biomedich-399	56	14	quercetin	quercetin	PROPN
biomedich-399	56	15	obtained	obtain	VERB
biomedich-399	56	16	from	from	ADP
biomedich-399	56	17	protein	protein	NOUN
biomedich-399	56	18	-	-	PUNCT
biomedich-399	56	19	ligand	ligand	NOUN
biomedich-399	56	20	interaction	interaction	NOUN
biomedich-399	56	21	profiler	profiler	NOUN
biomedich-399	56	22	.	.	PUNCT
biomedich-399	57	1	lawan	lawan	PROPN
biomedich-399	57	2	&	&	CCONJ
biomedich-399	57	3	tharakee	tharakee	PROPN
biomedich-399	57	4	–	–	PUNCT
biomedich-399	57	5	dna	dna	NOUN
biomedich-399	57	6	gyrase	gyrase	NOUN
biomedich-399	57	7	inhibition	inhibition	NOUN
biomedich-399	57	8	by	by	ADP
biomedich-399	57	9	grape	grape	NOUN
biomedich-399	57	10	metabolites	metabolite	NOUN
biomedich-399	57	11	589	589	NUM
biomedich-399	57	12	a.	a.	NOUN
biomedich-399	57	13	b.	b.	PROPN
biomedich-399	57	14	c.	c.	PROPN
biomedich-399	57	15	d.	d.	PROPN
biomedich-399	57	16	e.	e.	PROPN
biomedich-399	57	17	f.	f.	PROPN
biomedich-399	57	18	g.	g.	PROPN
biomedich-399	57	19	h.	h.	PROPN
biomedich-399	57	20	i.	i.	PROPN
biomedich-399	57	21	590	590	NUM
biomedich-399	57	22	biology	biology	NOUN
biomedich-399	57	23	,	,	PUNCT
biomedich-399	57	24	medicine	medicine	NOUN
biomedich-399	57	25	,	,	PUNCT
biomedich-399	57	26	&	&	CCONJ
biomedich-399	57	27	natural	natural	ADJ
biomedich-399	57	28	product	product	NOUN
biomedich-399	57	29	chemistry	chemistry	NOUN
biomedich-399	57	30	12	12	NUM
biomedich-399	57	31	(	(	PUNCT
biomedich-399	57	32	2	2	NUM
biomedich-399	57	33	)	)	PUNCT
biomedich-399	57	34	,	,	PUNCT
biomedich-399	57	35	2023	2023	NUM
biomedich-399	57	36	:	:	PUNCT
biomedich-399	57	37	585	585	NUM
biomedich-399	57	38	-	-	SYM
biomedich-399	57	39	592	592	NUM
biomedich-399	57	40	j.	j.	PROPN
biomedich-399	57	41	k.	k.	PROPN
biomedich-399	57	42	figure	figure	NOUN
biomedich-399	57	43	4	4	NUM
biomedich-399	57	44	.	.	PUNCT
biomedich-399	57	45	diagram	diagram	NOUN
biomedich-399	57	46	showing	show	VERB
biomedich-399	57	47	the	the	DET
biomedich-399	57	48	amino	amino	NOUN
biomedich-399	57	49	acid	acid	NOUN
biomedich-399	57	50	residues	residue	NOUN
biomedich-399	57	51	that	that	PRON
biomedich-399	57	52	interact	interact	VERB
biomedich-399	57	53	with	with	ADP
biomedich-399	57	54	ligand	ligand	NOUN
biomedich-399	57	55	,	,	PUNCT
biomedich-399	57	56	a.	a.	PROPN
biomedich-399	57	57	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	57	58	b.	b.	PROPN
biomedich-399	58	1	(	(	PUNCT
biomedich-399	58	2	-)-catechin	-)-catechin	PROPN
biomedich-399	58	3	c.	c.	PROPN
biomedich-399	58	4	epicatechin	epicatechin	PROPN
biomedich-399	58	5	d.	d.	PROPN
biomedich-399	58	6	epicatechin	epicatechin	PROPN
biomedich-399	58	7	e.	e.	PROPN
biomedich-399	58	8	procyanidinb1	procyanidinb1	PROPN
biomedich-399	59	1	f.	f.	PROPN
biomedich-399	59	2	(	(	PUNCT
biomedich-399	59	3	+	+	ADJ
biomedich-399	59	4	)	)	PUNCT
biomedich-399	59	5	-gallocatechin	-gallocatechin	PROPN
biomedich-399	59	6	g.	g.	PROPN
biomedich-399	59	7	epigallocatechin	epigallocatechin	PROPN
biomedich-399	59	8	h.	h.	PROPN
biomedich-399	59	9	procyanidin	procyanidin	PROPN
biomedich-399	59	10	-	-	PUNCT
biomedich-399	59	11	b3	b3	PROPN
biomedich-399	59	12	i.	i.	NOUN
biomedich-399	59	13	procyanidin	procyanidin	NOUN
biomedich-399	59	14	-	-	PUNCT
biomedich-399	59	15	b2	b2	NOUN
biomedich-399	59	16	j.	j.	PROPN
biomedich-399	59	17	procyanidin	procyanidin	PROPN
biomedich-399	59	18	-	-	PUNCT
biomedich-399	59	19	b4	b4	PROPN
biomedich-399	59	20	k.	k.	PROPN
biomedich-399	59	21	quercetin	quercetin	PROPN
biomedich-399	59	22	that	that	PRON
biomedich-399	59	23	generated	generate	VERB
biomedich-399	59	24	using	use	VERB
biomedich-399	59	25	protein	protein	NOUN
biomedich-399	59	26	-	-	PUNCT
biomedich-399	59	27	ligand	ligand	NOUN
biomedich-399	59	28	interaction	interaction	NOUN
biomedich-399	59	29	profiler	profiler	NOUN
biomedich-399	59	30	.	.	PUNCT
biomedich-399	60	1	table	table	NOUN
biomedich-399	60	2	2	2	NUM
biomedich-399	60	3	.	.	PUNCT
biomedich-399	60	4	predicted	predict	VERB
biomedich-399	60	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	60	6	properties	property	NOUN
biomedich-399	60	7	of	of	ADP
biomedich-399	60	8	studied	study	VERB
biomedich-399	60	9	secondary	secondary	ADJ
biomedich-399	60	10	metabolites	metabolite	NOUN
biomedich-399	60	11	;	;	PUNCT
biomedich-399	60	12	1	1	NUM
biomedich-399	60	13	-	-	PUNCT
biomedich-399	60	14	water	water	NOUN
biomedich-399	60	15	solubility	solubility	NOUN
biomedich-399	60	16	(	(	PUNCT
biomedich-399	60	17	log	log	PROPN
biomedich-399	60	18	mol	mol	PROPN
biomedich-399	60	19	/	/	SYM
biomedich-399	60	20	l	l	NOUN
biomedich-399	60	21	)	)	PUNCT
biomedich-399	60	22	2	2	NUM
biomedich-399	60	23	-	-	PUNCT
biomedich-399	60	24	human	human	ADJ
biomedich-399	60	25	intestinal	intestinal	ADJ
biomedich-399	60	26	absorption	absorption	NOUN
biomedich-399	60	27	(	(	PUNCT
biomedich-399	60	28	%	%	NOUN
biomedich-399	60	29	absorbed	absorb	VERB
biomedich-399	60	30	)	)	PUNCT
biomedich-399	60	31	3	3	NUM
biomedich-399	60	32	-	-	PUNCT
biomedich-399	60	33	volume	volume	NOUN
biomedich-399	60	34	of	of	ADP
biomedich-399	60	35	distribution	distribution	NOUN
biomedich-399	60	36	at	at	ADP
biomedich-399	60	37	steady	steady	ADJ
biomedich-399	60	38	-	-	PUNCT
biomedich-399	60	39	state	state	NOUN
biomedich-399	60	40	(	(	PUNCT
biomedich-399	60	41	log	log	NOUN
biomedich-399	60	42	l	l	NOUN
biomedich-399	60	43	/	/	SYM
biomedich-399	60	44	kg	kg	NOUN
biomedich-399	60	45	)	)	PUNCT
biomedich-399	60	46	4	4	NUM
biomedich-399	60	47	-	-	PUNCT
biomedich-399	60	48	fraction	fraction	NOUN
biomedich-399	60	49	unbound	unbound	NOUN
biomedich-399	60	50	(	(	PUNCT
biomedich-399	60	51	fu	fu	NOUN
biomedich-399	60	52	)	)	PUNCT
biomedich-399	60	53	5	5	NUM
biomedich-399	60	54	-	-	PUNCT
biomedich-399	60	55	blood	blood	NOUN
biomedich-399	60	56	brain	brain	NOUN
biomedich-399	60	57	barrier	barrier	NOUN
biomedich-399	60	58	permeability	permeability	NOUN
biomedich-399	60	59	(	(	PUNCT
biomedich-399	60	60	log	log	NOUN
biomedich-399	60	61	bb	bb	NOUN
biomedich-399	60	62	)	)	PUNCT
biomedich-399	60	63	6	6	NUM
biomedich-399	60	64	-	-	PUNCT
biomedich-399	60	65	cytochromes	cytochrome	NOUN
biomedich-399	60	66	p450	p450	PROPN
biomedich-399	60	67	substrates	substrate	VERB
biomedich-399	60	68	7cytochromes	7cytochrome	NOUN
biomedich-399	60	69	p450	p450	NUM
biomedich-399	60	70	inhibitors	inhibitor	NOUN
biomedich-399	60	71	8total	8total	ADJ
biomedich-399	60	72	clearance	clearance	NOUN
biomedich-399	60	73	(	(	PUNCT
biomedich-399	60	74	log	log	VERB
biomedich-399	60	75	ml	ml	NOUN
biomedich-399	60	76	/	/	SYM
biomedich-399	60	77	min	min	NOUN
biomedich-399	60	78	/	/	SYM
biomedich-399	60	79	kg	kg	NOUN
biomedich-399	60	80	)	)	PUNCT
biomedich-399	60	81	9renal	9renal	NUM
biomedich-399	60	82	organic	organic	ADJ
biomedich-399	60	83	cation	cation	NOUN
biomedich-399	60	84	transporter	transporter	NOUN
biomedich-399	60	85	2	2	NUM
biomedich-399	60	86	substrate	substrate	NOUN
biomedich-399	60	87	10ames	10ames	NUM
biomedich-399	60	88	toxicity	toxicity	NOUN
biomedich-399	60	89	11max	11max	NOUN
biomedich-399	60	90	.	.	PUNCT
biomedich-399	61	1	tolerated	tolerate	VERB
biomedich-399	61	2	dose	dose	PROPN
biomedich-399	61	3	(	(	PUNCT
biomedich-399	61	4	human	human	NOUN
biomedich-399	61	5	)	)	PUNCT
biomedich-399	61	6	(	(	PUNCT
biomedich-399	61	7	log	log	VERB
biomedich-399	61	8	mg	mg	PROPN
biomedich-399	61	9	/	/	SYM
biomedich-399	61	10	kg	kg	PROPN
biomedich-399	61	11	/	/	SYM
biomedich-399	61	12	day	day	NOUN
biomedich-399	61	13	)	)	PUNCT
biomedich-399	61	14	12hepatotoxicity	12hepatotoxicity	NUM
biomedich-399	61	15	.	.	PUNCT
biomedich-399	62	1	compound	compound	NOUN
biomedich-399	62	2	absorption	absorption	NOUN
biomedich-399	62	3	distribution	distribution	NOUN
biomedich-399	62	4	metabolism	metabolism	NOUN
biomedich-399	62	5	excretion	excretion	NOUN
biomedich-399	62	6	toxicity	toxicity	NOUN
biomedich-399	62	7	ws1	ws1	PROPN
biomedich-399	62	8	hia2	hia2	PROPN
biomedich-399	62	9	vdss3	vdss3	PROPN
biomedich-399	62	10	fu4	fu4	PROPN
biomedich-399	62	11	bbb5	bbb5	PROPN
biomedich-399	62	12	cyps6	cyps6	PROPN
biomedich-399	62	13	cypi7	cypi7	PROPN
biomedich-399	63	1	tc8	tc8	PROPN
biomedich-399	63	2	ros9	ros9	PROPN
biomedich-399	63	3	ames10	ames10	NOUN
biomedich-399	63	4	mtd11	mtd11	PROPN
biomedich-399	63	5	ht12	ht12	PROPN
biomedich-399	63	6	ciprofloxacin	ciprofloxacin	NOUN
biomedich-399	63	7	-2.678	-2.678	PUNCT
biomedich-399	63	8	94.828	94.828	NUM
biomedich-399	63	9	0.293	0.293	NUM
biomedich-399	63	10	0.404	0.404	NUM
biomedich-399	63	11	-0.733	-0.733	PUNCT
biomedich-399	63	12	3a4	3a4	NUM
biomedich-399	63	13	0.505	0.505	NUM
biomedich-399	63	14	no	no	INTJ
biomedich-399	64	1	yes	yes	INTJ
biomedich-399	64	2	-0.283	-0.283	INTJ
biomedich-399	65	1	yes	yes	INTJ
biomedich-399	65	2	(	(	PUNCT
biomedich-399	65	3	-)-catechin	-)-catechin	X
biomedich-399	65	4	-3.024	-3.024	NUM
biomedich-399	65	5	72.536	72.536	NUM
biomedich-399	65	6	0.589	0.589	NUM
biomedich-399	65	7	0.152	0.152	NUM
biomedich-399	65	8	-1.278	-1.278	NUM
biomedich-399	65	9	0.286	0.286	NUM
biomedich-399	65	10	no	no	INTJ
biomedich-399	65	11	yes	yes	INTJ
biomedich-399	65	12	0.516	0.516	NUM
biomedich-399	65	13	no	no	INTJ
biomedich-399	65	14	(	(	PUNCT
biomedich-399	65	15	-)-epicatechin	-)-epicatechin	NOUN
biomedich-399	65	16	-3.024	-3.024	PROPN
biomedich-399	65	17	72.539	72.539	NUM
biomedich-399	65	18	0.589	0.589	NUM
biomedich-399	65	19	0.152	0.152	NUM
biomedich-399	65	20	-1.278	-1.278	NUM
biomedich-399	65	21	0.286	0.286	NUM
biomedich-399	65	22	no	no	PRON
biomedich-399	65	23	yes	yes	INTJ
biomedich-399	65	24	0.516	0.516	NUM
biomedich-399	65	25	no	no	DET
biomedich-399	65	26	epicatechin-3	epicatechin-3	PROPN
biomedich-399	65	27	-	-	NOUN
biomedich-399	65	28	gallate	gallate	NOUN
biomedich-399	65	29	-2.907	-2.907	NUM
biomedich-399	65	30	66.671	66.671	NUM
biomedich-399	65	31	0.051	0.051	NUM
biomedich-399	65	32	0.283	0.283	NUM
biomedich-399	65	33	-1.898	-1.898	PUNCT
biomedich-399	65	34	1a2	1a2	NUM
biomedich-399	65	35	0.016	0.016	NUM
biomedich-399	66	1	no	no	INTJ
biomedich-399	66	2	yes	yes	INTJ
biomedich-399	66	3	0.537	0.537	NUM
biomedich-399	66	4	no	no	DET
biomedich-399	66	5	procyanidin	procyanidin	NOUN
biomedich-399	66	6	-	-	PUNCT
biomedich-399	66	7	b1	b1	NOUN
biomedich-399	66	8	-2.892	-2.892	PUNCT
biomedich-399	66	9	64.165	64.165	NUM
biomedich-399	66	10	0.036	0.036	NUM
biomedich-399	66	11	0.386	0.386	NUM
biomedich-399	66	12	-2.263	-2.263	NUM
biomedich-399	66	13	0.289	0.289	NUM
biomedich-399	66	14	no	no	INTJ
biomedich-399	66	15	no	no	DET
biomedich-399	66	16	0.411	0.411	NUM
biomedich-399	66	17	no	no	NOUN
biomedich-399	66	18	(	(	PUNCT
biomedich-399	66	19	+	+	ADJ
biomedich-399	66	20	)	)	PUNCT
biomedich-399	66	21	-gallocatechin	-gallocatechin	NOUN
biomedich-399	66	22	-2.952	-2.952	NOUN
biomedich-399	66	23	60.140	60.140	NUM
biomedich-399	66	24	0.520	0.520	NUM
biomedich-399	66	25	0.156	0.156	NUM
biomedich-399	66	26	-1.598	-1.598	NOUN
biomedich-399	66	27	0.449	0.449	NUM
biomedich-399	66	28	no	no	INTJ
biomedich-399	66	29	no	no	DET
biomedich-399	66	30	0.755	0.755	NUM
biomedich-399	66	31	no	no	DET
biomedich-399	66	32	epigallocatechin	epigallocatechin	NOUN
biomedich-399	66	33	-2.952	-2.952	PUNCT
biomedich-399	67	1	60.140	60.140	NUM
biomedich-399	67	2	0.520	0.520	NUM
biomedich-399	67	3	0.156	0.156	NUM
biomedich-399	67	4	-1.598	-1.598	NOUN
biomedich-399	67	5	0.449	0.449	NUM
biomedich-399	67	6	no	no	INTJ
biomedich-399	67	7	no	no	DET
biomedich-399	67	8	0.755	0.755	NUM
biomedich-399	67	9	no	no	DET
biomedich-399	67	10	procyanidin	procyanidin	NOUN
biomedich-399	67	11	-	-	PUNCT
biomedich-399	67	12	b3	b3	NOUN
biomedich-399	67	13	-2.892	-2.892	PUNCT
biomedich-399	67	14	64.165	64.165	NUM
biomedich-399	67	15	0.036	0.036	NUM
biomedich-399	67	16	0.386	0.386	NUM
biomedich-399	67	17	-2.263	-2.263	NUM
biomedich-399	67	18	0.289	0.289	NUM
biomedich-399	67	19	no	no	INTJ
biomedich-399	67	20	no	no	DET
biomedich-399	67	21	0.411	0.411	NUM
biomedich-399	67	22	no	no	DET
biomedich-399	67	23	procyanidin	procyanidin	NOUN
biomedich-399	67	24	-	-	PUNCT
biomedich-399	67	25	b2	b2	NOUN
biomedich-399	67	26	-2.892	-2.892	NOUN
biomedich-399	67	27	64.165	64.165	NUM
biomedich-399	67	28	0.036	0.036	NUM
biomedich-399	67	29	0.386	0.386	NUM
biomedich-399	67	30	-2.263	-2.263	NUM
biomedich-399	67	31	0.289	0.289	NUM
biomedich-399	67	32	no	no	INTJ
biomedich-399	67	33	no	no	DET
biomedich-399	67	34	0.411	0.411	NUM
biomedich-399	67	35	no	no	DET
biomedich-399	67	36	procyanidin	procyanidin	NOUN
biomedich-399	67	37	-	-	NOUN
biomedich-399	67	38	b4	b4	NOUN
biomedich-399	67	39	-2.892	-2.892	PUNCT
biomedich-399	67	40	64.165	64.165	NUM
biomedich-399	67	41	0.036	0.036	NUM
biomedich-399	67	42	0.386	0.386	NUM
biomedich-399	67	43	-2.263	-2.263	NUM
biomedich-399	67	44	0.289	0.289	NUM
biomedich-399	67	45	no	no	INTJ
biomedich-399	67	46	no	no	DET
biomedich-399	67	47	0.411	0.411	NUM
biomedich-399	67	48	no	no	DET
biomedich-399	67	49	quercetin	quercetin	NOUN
biomedich-399	67	50	-2.982	-2.982	ADP
biomedich-399	67	51	74.840	74.840	NUM
biomedich-399	67	52	0.310	0.310	NUM
biomedich-399	67	53	0.128	0.128	NUM
biomedich-399	67	54	-1.377	-1.377	PUNCT
biomedich-399	68	1	1a2	1a2	NUM
biomedich-399	68	2	0.624	0.624	NUM
biomedich-399	69	1	no	no	INTJ
biomedich-399	69	2	yes	yes	INTJ
biomedich-399	69	3	0.954	0.954	NUM
biomedich-399	69	4	no	no	DET
biomedich-399	69	5	table	table	NOUN
biomedich-399	69	6	3	3	NUM
biomedich-399	69	7	.	.	PUNCT
biomedich-399	69	8	predicted	predict	VERB
biomedich-399	69	9	physicochemical	physicochemical	ADJ
biomedich-399	69	10	properties	property	NOUN
biomedich-399	69	11	of	of	ADP
biomedich-399	69	12	studied	study	VERB
biomedich-399	69	13	secondary	secondary	ADJ
biomedich-399	69	14	meabolites	meabolite	NOUN
biomedich-399	69	15	;	;	PUNCT
biomedich-399	69	16	1molecular	1molecular	NUM
biomedich-399	69	17	weight	weight	NOUN
biomedich-399	69	18	(	(	PUNCT
biomedich-399	69	19	g	g	NOUN
biomedich-399	69	20	/	/	SYM
biomedich-399	69	21	mol	mol	NOUN
biomedich-399	69	22	)	)	PUNCT
biomedich-399	69	23	2num	2num	PROPN
biomedich-399	69	24	.	.	PUNCT
biomedich-399	69	25	heavy	heavy	ADJ
biomedich-399	69	26	atoms	atom	NOUN
biomedich-399	69	27	3num	3num	NUM
biomedich-399	69	28	.	.	PUNCT
biomedich-399	70	1	rotatable	rotatable	ADJ
biomedich-399	70	2	bonds	bond	NOUN
biomedich-399	70	3	4num	4num	NOUN
biomedich-399	70	4	.	.	PUNCT
biomedich-399	71	1	h	h	NOUN
biomedich-399	71	2	-	-	PUNCT
biomedich-399	71	3	bond	bond	NOUN
biomedich-399	71	4	acceptors	acceptor	NOUN
biomedich-399	72	1	5num	5num	NUM
biomedich-399	72	2	.	.	PUNCT
biomedich-399	73	1	h	h	NOUN
biomedich-399	73	2	-	-	PUNCT
biomedich-399	73	3	bond	bond	NOUN
biomedich-399	73	4	donors	donor	NOUN
biomedich-399	73	5	6	6	NUM
biomedich-399	73	6	-	-	PUNCT
biomedich-399	73	7	topological	topological	ADJ
biomedich-399	73	8	polar	polar	ADJ
biomedich-399	73	9	surface	surface	NOUN
biomedich-399	73	10	area(å²	area(å²	NOUN
biomedich-399	73	11	)	)	PUNCT
biomedich-399	74	1	7octanol	7octanol	NUM
biomedich-399	74	2	/	/	SYM
biomedich-399	74	3	water	water	NOUN
biomedich-399	74	4	partition	partition	NOUN
biomedich-399	74	5	-	-	PUNCT
biomedich-399	74	6	coefficient	coefficient	NOUN
biomedich-399	74	7	8	8	NUM
biomedich-399	74	8	-	-	PUNCT
biomedich-399	74	9	lipinski	lipinski	PROPN
biomedich-399	74	10	’s	’s	PART
biomedich-399	74	11	rule	rule	NOUN
biomedich-399	74	12	of	of	ADP
biomedich-399	74	13	five	five	NUM
biomedich-399	74	14	9veber	9veber	NUM
biomedich-399	74	15	’s	’s	PART
biomedich-399	74	16	rule	rule	NOUN
biomedich-399	74	17	.	.	PUNCT
biomedich-399	75	1	compound	compound	NOUN
biomedich-399	75	2	mw1	mw1	PROPN
biomedich-399	75	3	n	n	CCONJ
biomedich-399	75	4	-	-	PUNCT
biomedich-399	75	5	nha2	nha2	PROPN
biomedich-399	75	6	n	n	CCONJ
biomedich-399	75	7	-	-	PUNCT
biomedich-399	75	8	rot3	rot3	NOUN
biomedich-399	75	9	n	n	CCONJ
biomedich-399	75	10	-	-	PUNCT
biomedich-399	75	11	hba4	hba4	PROPN
biomedich-399	75	12	n	n	CCONJ
biomedich-399	75	13	-	-	PUNCT
biomedich-399	75	14	hbd5	hbd5	NOUN
biomedich-399	75	15	tpsa6	tpsa6	NOUN
biomedich-399	76	1	milogp7	milogp7	NOUN
biomedich-399	76	2	lpi8	lpi8	NOUN
biomedich-399	76	3	ver9	ver9	PROPN
biomedich-399	76	4	bas10	bas10	PROPN
biomedich-399	76	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-399	76	6	331.34	331.34	NUM
biomedich-399	76	7	24	24	NUM
biomedich-399	76	8	3	3	NUM
biomedich-399	76	9	5	5	NUM
biomedich-399	76	10	2	2	NUM
biomedich-399	76	11	74.57	74.57	NUM
biomedich-399	76	12	1.28	1.28	NUM
biomedich-399	77	1	yes	yes	INTJ
biomedich-399	78	1	yes	yes	INTJ
biomedich-399	78	2	0.55	0.55	NUM
biomedich-399	78	3	(	(	PUNCT
biomedich-399	78	4	-)-catechin	-)-catechin	NUM
biomedich-399	78	5	290.27	290.27	NUM
biomedich-399	78	6	21	21	NUM
biomedich-399	78	7	1	1	NUM
biomedich-399	78	8	6	6	NUM
biomedich-399	78	9	5	5	NUM
biomedich-399	78	10	110.38	110.38	NUM
biomedich-399	78	11	0.24	0.24	NUM
biomedich-399	79	1	yes	yes	INTJ
biomedich-399	80	1	yes	yes	INTJ
biomedich-399	80	2	0.55	0.55	NUM
biomedich-399	80	3	(	(	PUNCT
biomedich-399	80	4	-)-epicatechin	-)-epicatechin	PROPN
biomedich-399	80	5	290.27	290.27	NUM
biomedich-399	80	6	21	21	NUM
biomedich-399	80	7	1	1	NUM
biomedich-399	80	8	6	6	NUM
biomedich-399	80	9	5	5	NUM
biomedich-399	80	10	110.38	110.38	NUM
biomedich-399	80	11	0.24	0.24	NUM
biomedich-399	81	1	yes	yes	INTJ
biomedich-399	82	1	yes	yes	INTJ
biomedich-399	82	2	0.55	0.55	NUM
biomedich-399	82	3	epicatechin-3	epicatechin-3	NOUN
biomedich-399	82	4	-	-	PUNCT
biomedich-399	82	5	gallate	gallate	NOUN
biomedich-399	82	6	442.37	442.37	NUM
biomedich-399	82	7	32	32	NUM
biomedich-399	82	8	4	4	NUM
biomedich-399	82	9	10	10	NUM
biomedich-399	82	10	7	7	NUM
biomedich-399	82	11	177.14	177.14	NUM
biomedich-399	82	12	0.32	0.32	NUM
biomedich-399	82	13	yes	yes	INTJ
biomedich-399	82	14	no	no	DET
biomedich-399	82	15	0.55	0.55	NUM
biomedich-399	82	16	procyanidin	procyanidin	NOUN
biomedich-399	82	17	-	-	PUNCT
biomedich-399	82	18	b1	b1	NOUN
biomedich-399	82	19	578.52	578.52	NUM
biomedich-399	82	20	42	42	NUM
biomedich-399	82	21	3	3	NUM
biomedich-399	82	22	12	12	NUM
biomedich-399	82	23	10	10	NUM
biomedich-399	82	24	220.76	220.76	NUM
biomedich-399	82	25	-0.26	-0.26	NOUN
biomedich-399	83	1	no	no	INTJ
biomedich-399	83	2	no	no	INTJ
biomedich-399	83	3	0.17	0.17	NUM
biomedich-399	83	4	(	(	PUNCT
biomedich-399	83	5	+	+	ADJ
biomedich-399	83	6	)	)	PUNCT
biomedich-399	83	7	-gallocatechin	-gallocatechin	NOUN
biomedich-399	83	8	306.27	306.27	NUM
biomedich-399	83	9	22	22	NUM
biomedich-399	83	10	1	1	NUM
biomedich-399	83	11	7	7	NUM
biomedich-399	83	12	6	6	NUM
biomedich-399	83	13	130.61	130.61	NUM
biomedich-399	83	14	-0.29	-0.29	NOUN
biomedich-399	84	1	yes	yes	INTJ
biomedich-399	84	2	yes	yes	INTJ
biomedich-399	84	3	0.55	0.55	NUM
biomedich-399	84	4	epigallocatechin	epigallocatechin	NOUN
biomedich-399	84	5	306.27	306.27	NUM
biomedich-399	84	6	22	22	NUM
biomedich-399	84	7	1	1	NUM
biomedich-399	84	8	7	7	NUM
biomedich-399	84	9	6	6	NUM
biomedich-399	84	10	130.61	130.61	NUM
biomedich-399	84	11	-0.29	-0.29	NOUN
biomedich-399	85	1	yes	yes	INTJ
biomedich-399	85	2	yes	yes	INTJ
biomedich-399	85	3	0.55	0.55	NUM
biomedich-399	85	4	procyanidin	procyanidin	NOUN
biomedich-399	85	5	-	-	PUNCT
biomedich-399	85	6	b3	b3	NOUN
biomedich-399	85	7	578.52	578.52	NUM
biomedich-399	85	8	42	42	NUM
biomedich-399	85	9	3	3	NUM
biomedich-399	85	10	12	12	NUM
biomedich-399	85	11	10	10	NUM
biomedich-399	85	12	220.76	220.76	NUM
biomedich-399	85	13	-0.26	-0.26	NOUN
biomedich-399	85	14	no	no	INTJ
biomedich-399	85	15	no	no	DET
biomedich-399	85	16	0.17	0.17	NUM
biomedich-399	85	17	procyanidin	procyanidin	NOUN
biomedich-399	85	18	-	-	PUNCT
biomedich-399	85	19	b2	b2	NOUN
biomedich-399	85	20	578.52	578.52	NUM
biomedich-399	85	21	42	42	NUM
biomedich-399	85	22	3	3	NUM
biomedich-399	85	23	12	12	NUM
biomedich-399	85	24	10	10	NUM
biomedich-399	85	25	220.76	220.76	NUM
biomedich-399	85	26	-0.26	-0.26	NOUN
biomedich-399	85	27	no	no	INTJ
biomedich-399	85	28	no	no	DET
biomedich-399	85	29	0.17	0.17	NUM
biomedich-399	85	30	procyanidin	procyanidin	NOUN
biomedich-399	85	31	-	-	NOUN
biomedich-399	85	32	b4	b4	NOUN
biomedich-399	85	33	578.52	578.52	NUM
biomedich-399	85	34	42	42	NUM
biomedich-399	85	35	3	3	NUM
biomedich-399	85	36	12	12	NUM
biomedich-399	85	37	10	10	NUM
biomedich-399	85	38	220.76	220.76	NUM
biomedich-399	85	39	-0.26	-0.26	NOUN
biomedich-399	85	40	no	no	INTJ
biomedich-399	85	41	no	no	DET
biomedich-399	85	42	0.17	0.17	NUM
biomedich-399	85	43	quercetin	quercetin	NOUN
biomedich-399	85	44	302.24	302.24	NUM
biomedich-399	85	45	22	22	NUM
biomedich-399	85	46	1	1	NUM
biomedich-399	85	47	7	7	NUM
biomedich-399	85	48	5	5	NUM
biomedich-399	85	49	131.36	131.36	NUM
biomedich-399	85	50	-0.56	-0.56	NUM
biomedich-399	86	1	yes	yes	INTJ
biomedich-399	86	2	yes	yes	INTJ
biomedich-399	86	3	0.55	0.55	NUM
biomedich-399	86	4	lawan	lawan	PROPN
biomedich-399	86	5	&	&	CCONJ
biomedich-399	86	6	tharakee	tharakee	PROPN
biomedich-399	86	7	–	–	PUNCT
biomedich-399	86	8	dna	dna	NOUN
biomedich-399	86	9	gyrase	gyrase	NOUN
biomedich-399	86	10	inhibition	inhibition	NOUN
biomedich-399	86	11	by	by	ADP
biomedich-399	86	12	grape	grape	NOUN
biomedich-399	86	13	metabolites	metabolite	NOUN
biomedich-399	86	14	591	591	NUM
biomedich-399	86	15	discussion	discussion	NOUN
biomedich-399	86	16	in	in	ADP
biomedich-399	86	17	this	this	DET
biomedich-399	86	18	study	study	NOUN
biomedich-399	86	19	,	,	PUNCT
biomedich-399	86	20	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	86	21	was	be	AUX
biomedich-399	86	22	used	use	VERB
biomedich-399	86	23	as	as	ADP
biomedich-399	86	24	the	the	DET
biomedich-399	86	25	reference	reference	NOUN
biomedich-399	86	26	compound	compound	NOUN
biomedich-399	86	27	,	,	PUNCT
biomedich-399	86	28	the	the	DET
biomedich-399	86	29	known	known	ADJ
biomedich-399	86	30	bacterial	bacterial	ADJ
biomedich-399	86	31	dna	dna	NOUN
biomedich-399	86	32	gyrase	gyrase	NOUN
biomedich-399	86	33	subunit	subunit	NOUN
biomedich-399	86	34	b	b	PROPN
biomedich-399	86	35	inhibitor	inhibitor	NOUN
biomedich-399	86	36	,	,	PUNCT
biomedich-399	86	37	to	to	PART
biomedich-399	86	38	compare	compare	VERB
biomedich-399	86	39	the	the	DET
biomedich-399	86	40	binding	bind	VERB
biomedich-399	86	41	energies	energy	NOUN
biomedich-399	86	42	and	and	CCONJ
biomedich-399	86	43	inhibition	inhibition	VERB
biomedich-399	86	44	constants	constant	NOUN
biomedich-399	86	45	with	with	ADP
biomedich-399	86	46	the	the	DET
biomedich-399	86	47	examined	examine	VERB
biomedich-399	86	48	secondary	secondary	ADJ
biomedich-399	86	49	metabolites	metabolite	NOUN
biomedich-399	86	50	.	.	PUNCT
biomedich-399	87	1	the	the	DET
biomedich-399	87	2	concentration	concentration	NOUN
biomedich-399	87	3	needed	need	VERB
biomedich-399	87	4	to	to	PART
biomedich-399	87	5	cause	cause	VERB
biomedich-399	87	6	half	half	NOUN
biomedich-399	87	7	of	of	ADP
biomedich-399	87	8	the	the	DET
biomedich-399	87	9	maximum	maximum	ADJ
biomedich-399	87	10	inhibition	inhibition	NOUN
biomedich-399	87	11	is	be	AUX
biomedich-399	87	12	known	know	VERB
biomedich-399	87	13	as	as	ADP
biomedich-399	87	14	the	the	DET
biomedich-399	87	15	inhibition	inhibition	NOUN
biomedich-399	87	16	constant	constant	ADJ
biomedich-399	87	17	(	(	PUNCT
biomedich-399	87	18	ki	ki	PROPN
biomedich-399	87	19	)	)	PUNCT
biomedich-399	87	20	,	,	PUNCT
biomedich-399	87	21	which	which	PRON
biomedich-399	87	22	serves	serve	VERB
biomedich-399	87	23	as	as	ADP
biomedich-399	87	24	a	a	DET
biomedich-399	87	25	measure	measure	NOUN
biomedich-399	87	26	of	of	ADP
biomedich-399	87	27	an	an	DET
biomedich-399	87	28	inhibitor	inhibitor	NOUN
biomedich-399	87	29	's	's	PART
biomedich-399	87	30	potency	potency	NOUN
biomedich-399	87	31	.	.	PUNCT
biomedich-399	88	1	when	when	SCONJ
biomedich-399	88	2	comparing	compare	VERB
biomedich-399	88	3	the	the	DET
biomedich-399	88	4	binding	bind	VERB
biomedich-399	88	5	energies	energy	NOUN
biomedich-399	88	6	of	of	ADP
biomedich-399	88	7	docked	docked	ADJ
biomedich-399	88	8	ligands	ligand	NOUN
biomedich-399	88	9	and	and	CCONJ
biomedich-399	88	10	reference	reference	NOUN
biomedich-399	88	11	drug	drug	NOUN
biomedich-399	88	12	,	,	PUNCT
biomedich-399	88	13	(	(	PUNCT
biomedich-399	88	14	-)-catechin	-)-catechin	X
biomedich-399	88	15	(	(	PUNCT
biomedich-399	88	16	-6.22	-6.22	ADJ
biomedich-399	88	17	kcal	kcal	PROPN
biomedich-399	88	18	/	/	SYM
biomedich-399	88	19	mol	mol	NOUN
biomedich-399	88	20	)	)	PUNCT
biomedich-399	88	21	and	and	CCONJ
biomedich-399	88	22	procyanidin	procyanidin	NOUN
biomedich-399	88	23	-	-	PUNCT
biomedich-399	88	24	b2(-6.31	b2(-6.31	NOUN
biomedich-399	88	25	kcal	kcal	PROPN
biomedich-399	88	26	/	/	SYM
biomedich-399	88	27	mol	mol	NOUN
biomedich-399	88	28	)	)	PUNCT
biomedich-399	88	29	exhibit	exhibit	VERB
biomedich-399	88	30	even	even	ADV
biomedich-399	88	31	better	well	ADV
biomedich-399	88	32	binding	bind	VERB
biomedich-399	88	33	affinity	affinity	NOUN
biomedich-399	88	34	to	to	ADP
biomedich-399	88	35	the	the	DET
biomedich-399	88	36	target	target	NOUN
biomedich-399	88	37	protein	protein	NOUN
biomedich-399	88	38	than	than	ADP
biomedich-399	88	39	ciprofloxacin	ciprofloxacin	NOUN
biomedich-399	88	40	(	(	PUNCT
biomedich-399	88	41	6.19	6.19	NUM
biomedich-399	88	42	kcal	kcal	NOUN
biomedich-399	88	43	/	/	SYM
biomedich-399	88	44	mol	mol	NOUN
biomedich-399	88	45	)	)	PUNCT
biomedich-399	88	46	.	.	PUNCT
biomedich-399	89	1	(	(	PUNCT
biomedich-399	89	2	table	table	NOUN
biomedich-399	89	3	01	01	NUM
biomedich-399	89	4	)	)	PUNCT
biomedich-399	89	5	also	also	ADV
biomedich-399	89	6	,	,	PUNCT
biomedich-399	89	7	those	those	DET
biomedich-399	89	8	two	two	NUM
biomedich-399	89	9	compounds	compound	NOUN
biomedich-399	89	10	show	show	VERB
biomedich-399	89	11	lower	low	ADJ
biomedich-399	89	12	ki	ki	PROPN
biomedich-399	89	13	values	value	NOUN
biomedich-399	89	14	than	than	ADP
biomedich-399	89	15	ciprofloxacin	ciprofloxacin	NOUN
biomedich-399	89	16	,	,	PUNCT
biomedich-399	89	17	indicating	indicate	VERB
biomedich-399	89	18	better	well	ADJ
biomedich-399	89	19	potency	potency	NOUN
biomedich-399	89	20	towards	towards	ADP
biomedich-399	89	21	the	the	DET
biomedich-399	89	22	gyrb	gyrb	NOUN
biomedich-399	89	23	inhibition	inhibition	NOUN
biomedich-399	89	24	.	.	PUNCT
biomedich-399	90	1	it	it	PRON
biomedich-399	90	2	was	be	AUX
biomedich-399	90	3	evident	evident	ADJ
biomedich-399	90	4	that	that	SCONJ
biomedich-399	90	5	the	the	DET
biomedich-399	90	6	top	top	ADV
biomedich-399	90	7	-	-	PUNCT
biomedich-399	90	8	ranked	rank	VERB
biomedich-399	90	9	phytochemical	phytochemical	ADJ
biomedich-399	90	10	structures	structure	NOUN
biomedich-399	90	11	'	'	PART
biomedich-399	90	12	hydroxyl	hydroxyl	NOUN
biomedich-399	90	13	groups	group	NOUN
biomedich-399	90	14	play	play	VERB
biomedich-399	90	15	a	a	DET
biomedich-399	90	16	substantial	substantial	ADJ
biomedich-399	90	17	role	role	NOUN
biomedich-399	90	18	in	in	ADP
biomedich-399	90	19	the	the	DET
biomedich-399	90	20	establishment	establishment	NOUN
biomedich-399	90	21	of	of	ADP
biomedich-399	90	22	potent	potent	ADJ
biomedich-399	90	23	hydrogen	hydrogen	NOUN
biomedich-399	90	24	bonds	bond	NOUN
biomedich-399	90	25	with	with	ADP
biomedich-399	90	26	amino	amino	NOUN
biomedich-399	90	27	acid	acid	NOUN
biomedich-399	90	28	residues	residue	NOUN
biomedich-399	90	29	in	in	ADP
biomedich-399	90	30	the	the	DET
biomedich-399	90	31	binding	bind	VERB
biomedich-399	90	32	pockets	pocket	NOUN
biomedich-399	90	33	.	.	PUNCT
biomedich-399	91	1	(	(	PUNCT
biomedich-399	91	2	figure	figure	NOUN
biomedich-399	91	3	02	02	NUM
biomedich-399	91	4	)	)	PUNCT
biomedich-399	91	5	when	when	SCONJ
biomedich-399	91	6	considering	consider	VERB
biomedich-399	91	7	the	the	DET
biomedich-399	91	8	binding	bind	VERB
biomedich-399	91	9	interactions	interaction	NOUN
biomedich-399	91	10	of	of	ADP
biomedich-399	91	11	those	those	DET
biomedich-399	91	12	three	three	NUM
biomedich-399	91	13	ligands	ligand	NOUN
biomedich-399	91	14	,	,	PUNCT
biomedich-399	91	15	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	91	16	shows	show	VERB
biomedich-399	91	17	only	only	ADV
biomedich-399	91	18	one	one	NUM
biomedich-399	91	19	hydrogen	hydrogen	NOUN
biomedich-399	91	20	bonding	bonding	NOUN
biomedich-399	91	21	interaction	interaction	NOUN
biomedich-399	91	22	with	with	ADP
biomedich-399	91	23	the	the	DET
biomedich-399	91	24	protein	protein	NOUN
biomedich-399	91	25	(	(	PUNCT
biomedich-399	91	26	with	with	ADP
biomedich-399	91	27	asn46	asn46	NOUN
biomedich-399	91	28	)	)	PUNCT
biomedich-399	91	29	.	.	PUNCT
biomedich-399	92	1	but	but	CCONJ
biomedich-399	92	2	(	(	PUNCT
biomedich-399	92	3	)	)	PUNCT
biomedich-399	92	4	-catechin	-catechin	ADJ
biomedich-399	92	5	and	and	CCONJ
biomedich-399	92	6	procyanidin	procyanidin	NOUN
biomedich-399	92	7	-	-	PUNCT
biomedich-399	92	8	b2	b2	NOUN
biomedich-399	92	9	shows	show	VERB
biomedich-399	92	10	six	six	NUM
biomedich-399	92	11	(	(	PUNCT
biomedich-399	92	12	with	with	ADP
biomedich-399	92	13	val43	val43	NOUN
biomedich-399	92	14	,	,	PUNCT
biomedich-399	92	15	asp72	asp72	PROPN
biomedich-399	92	16	,	,	PUNCT
biomedich-399	92	17	gly77	gly77	PROPN
biomedich-399	92	18	&	&	CCONJ
biomedich-399	92	19	glu50	glu50	PROPN
biomedich-399	92	20	)	)	PUNCT
biomedich-399	92	21	and	and	CCONJ
biomedich-399	92	22	seven	seven	NUM
biomedich-399	92	23	(	(	PUNCT
biomedich-399	92	24	with	with	ADP
biomedich-399	92	25	ile94	ile94	PROPN
biomedich-399	92	26	,	,	PUNCT
biomedich-399	92	27	val120	val120	PROPN
biomedich-399	92	28	,	,	PUNCT
biomedich-399	92	29	asn46	asn46	PROPN
biomedich-399	92	30	,	,	PUNCT
biomedich-399	92	31	asp49	asp49	PROPN
biomedich-399	92	32	,	,	PUNCT
biomedich-399	92	33	glu50	glu50	PROPN
biomedich-399	92	34	,	,	PUNCT
biomedich-399	92	35	thr165	thr165	PROPN
biomedich-399	92	36	&	&	CCONJ
biomedich-399	92	37	asp73	asp73	PROPN
biomedich-399	92	38	)	)	PUNCT
biomedich-399	92	39	(	(	PUNCT
biomedich-399	92	40	figure	figure	VERB
biomedich-399	92	41	3	3	NUM
biomedich-399	92	42	)	)	PUNCT
biomedich-399	92	43	hydrogen	hydrogen	NOUN
biomedich-399	92	44	bonding	bonding	NOUN
biomedich-399	92	45	interactions	interaction	NOUN
biomedich-399	92	46	with	with	ADP
biomedich-399	92	47	the	the	DET
biomedich-399	92	48	target	target	NOUN
biomedich-399	92	49	protein	protein	NOUN
biomedich-399	92	50	,	,	PUNCT
biomedich-399	92	51	respectively	respectively	ADV
biomedich-399	92	52	.	.	PUNCT
biomedich-399	93	1	epicatechin-3	epicatechin-3	PROPN
biomedich-399	93	2	-	-	PUNCT
biomedich-399	93	3	gallate	gallate	NOUN
biomedich-399	93	4	shows	show	VERB
biomedich-399	93	5	the	the	DET
biomedich-399	93	6	lowest	low	ADJ
biomedich-399	93	7	(	(	PUNCT
biomedich-399	93	8	4.46	4.46	NUM
biomedich-399	93	9	kcal	kcal	NOUN
biomedich-399	93	10	/	/	SYM
biomedich-399	93	11	mol	mol	NOUN
biomedich-399	93	12	)	)	PUNCT
biomedich-399	93	13	binding	bind	VERB
biomedich-399	93	14	affinity	affinity	NOUN
biomedich-399	93	15	towards	towards	ADP
biomedich-399	93	16	the	the	DET
biomedich-399	93	17	target	target	NOUN
biomedich-399	93	18	protein	protein	NOUN
biomedich-399	93	19	and	and	CCONJ
biomedich-399	93	20	the	the	DET
biomedich-399	93	21	highest	high	ADJ
biomedich-399	93	22	inhibition	inhibition	NOUN
biomedich-399	93	23	constant	constant	ADJ
biomedich-399	93	24	(	(	PUNCT
biomedich-399	93	25	540.36	540.36	NUM
biomedich-399	93	26	µm	µm	NOUN
biomedich-399	93	27	)	)	PUNCT
biomedich-399	93	28	from	from	ADP
biomedich-399	93	29	the	the	DET
biomedich-399	93	30	examined	examine	VERB
biomedich-399	93	31	ligands	ligand	NOUN
biomedich-399	93	32	.	.	PUNCT
biomedich-399	94	1	although	although	SCONJ
biomedich-399	94	2	it	it	PRON
biomedich-399	94	3	is	be	AUX
biomedich-399	94	4	not	not	PART
biomedich-399	94	5	mush	mush	NOUN
biomedich-399	94	6	as	as	ADP
biomedich-399	94	7	(	(	PUNCT
biomedich-399	94	8	-)-catechin	-)-catechin	ADJ
biomedich-399	94	9	and	and	CCONJ
biomedich-399	94	10	procyanidin	procyanidin	NOUN
biomedich-399	94	11	-	-	PUNCT
biomedich-399	94	12	b2	b2	NOUN
biomedich-399	94	13	,	,	PUNCT
biomedich-399	94	14	phytochemicals	phytochemical	VERB
biomedich-399	94	15	procyanidin	procyanidin	NOUN
biomedich-399	94	16	-	-	PUNCT
biomedich-399	94	17	b3(5.59	b3(5.59	NOUN
biomedich-399	94	18	kcal	kcal	PROPN
biomedich-399	94	19	/	/	SYM
biomedich-399	94	20	mol	mol	PROPN
biomedich-399	94	21	)	)	PUNCT
biomedich-399	94	22	,	,	PUNCT
biomedich-399	94	23	b4(-5.60	b4(-5.60	PROPN
biomedich-399	94	24	kcal	kcal	PROPN
biomedich-399	94	25	/	/	SYM
biomedich-399	94	26	mol	mol	NOUN
biomedich-399	94	27	)	)	PUNCT
biomedich-399	94	28	,	,	PUNCT
biomedich-399	94	29	(	(	PUNCT
biomedich-399	94	30	-)-epicatechin	-)-epicatechin	X
biomedich-399	94	31	(	(	PUNCT
biomedich-399	94	32	5.32	5.32	NUM
biomedich-399	94	33	kcal	kcal	NOUN
biomedich-399	94	34	/	/	SYM
biomedich-399	94	35	mol	mol	NOUN
biomedich-399	94	36	)	)	PUNCT
biomedich-399	94	37	and	and	CCONJ
biomedich-399	94	38	quercetin	quercetin	NOUN
biomedich-399	94	39	(	(	PUNCT
biomedich-399	94	40	-5.36	-5.36	NOUN
biomedich-399	94	41	kcal	kcal	PROPN
biomedich-399	94	42	/	/	SYM
biomedich-399	94	43	mol	mol	NOUN
biomedich-399	94	44	)	)	PUNCT
biomedich-399	94	45	also	also	ADV
biomedich-399	94	46	exhibits	exhibit	VERB
biomedich-399	94	47	good	good	ADJ
biomedich-399	94	48	binding	binding	ADJ
biomedich-399	94	49	capabilities	capability	NOUN
biomedich-399	94	50	.	.	PUNCT
biomedich-399	95	1	major	major	ADJ
biomedich-399	95	2	types	type	NOUN
biomedich-399	95	3	of	of	ADP
biomedich-399	95	4	binding	bind	VERB
biomedich-399	95	5	interactions	interaction	NOUN
biomedich-399	95	6	between	between	ADP
biomedich-399	95	7	the	the	DET
biomedich-399	95	8	protein	protein	NOUN
biomedich-399	95	9	and	and	CCONJ
biomedich-399	95	10	the	the	DET
biomedich-399	95	11	ligands	ligand	NOUN
biomedich-399	95	12	are	be	AUX
biomedich-399	95	13	h	h	NOUN
biomedich-399	95	14	-	-	PUNCT
biomedich-399	95	15	bonding	bond	VERB
biomedich-399	95	16	and	and	CCONJ
biomedich-399	95	17	hydrophobic	hydrophobic	NOUN
biomedich-399	95	18	interactions	interaction	NOUN
biomedich-399	95	19	.	.	PUNCT
biomedich-399	96	1	other	other	ADJ
biomedich-399	96	2	than	than	ADP
biomedich-399	96	3	that	that	PRON
biomedich-399	96	4	,	,	PUNCT
biomedich-399	96	5	π	π	PROPN
biomedich-399	96	6	-	-	NOUN
biomedich-399	96	7	cation	cation	NOUN
biomedich-399	96	8	interactions	interaction	NOUN
biomedich-399	96	9	also	also	ADV
biomedich-399	96	10	can	can	AUX
biomedich-399	96	11	be	be	AUX
biomedich-399	96	12	observed	observe	VERB
biomedich-399	96	13	in	in	ADP
biomedich-399	96	14	two	two	NUM
biomedich-399	96	15	cases	case	NOUN
biomedich-399	96	16	which	which	PRON
biomedich-399	96	17	are	be	AUX
biomedich-399	96	18	(	(	PUNCT
biomedich-399	96	19	-)-epicatechin	-)-epicatechin	X
biomedich-399	96	20	and	and	CCONJ
biomedich-399	96	21	procyanidin	procyanidin	NOUN
biomedich-399	96	22	-	-	PUNCT
biomedich-399	96	23	b3	b3	NOUN
biomedich-399	96	24	.	.	PUNCT
biomedich-399	97	1	interestingly	interestingly	ADV
biomedich-399	97	2	in	in	ADP
biomedich-399	97	3	both	both	DET
biomedich-399	97	4	cases	case	NOUN
biomedich-399	97	5	,	,	PUNCT
biomedich-399	97	6	π	π	NOUN
biomedich-399	97	7	-	-	PUNCT
biomedich-399	97	8	cation	cation	NOUN
biomedich-399	97	9	interactions	interaction	NOUN
biomedich-399	97	10	have	have	AUX
biomedich-399	97	11	occurred	occur	VERB
biomedich-399	97	12	between	between	ADP
biomedich-399	97	13	the	the	DET
biomedich-399	97	14	aromatic	aromatic	ADJ
biomedich-399	97	15	rings	ring	NOUN
biomedich-399	97	16	in	in	ADP
biomedich-399	97	17	the	the	DET
biomedich-399	97	18	ligands	ligand	NOUN
biomedich-399	97	19	and	and	CCONJ
biomedich-399	97	20	the	the	DET
biomedich-399	97	21	arg76	arg76	NOUN
biomedich-399	97	22	amino	amino	NOUN
biomedich-399	97	23	acid	acid	NOUN
biomedich-399	97	24	.	.	PUNCT
biomedich-399	98	1	from	from	ADP
biomedich-399	98	2	the	the	DET
biomedich-399	98	3	leading	lead	VERB
biomedich-399	98	4	phytochemicals	phytochemical	NOUN
biomedich-399	98	5	observed	observe	VERB
biomedich-399	98	6	with	with	ADP
biomedich-399	98	7	the	the	DET
biomedich-399	98	8	highest	high	ADJ
biomedich-399	98	9	binding	bind	VERB
biomedich-399	98	10	affinities	affinity	NOUN
biomedich-399	98	11	,	,	PUNCT
biomedich-399	98	12	(	(	PUNCT
biomedich-399	98	13	-)-catechin	-)-catechin	X
biomedich-399	98	14	meets	meet	VERB
biomedich-399	98	15	lipinski	lipinski	PROPN
biomedich-399	98	16	's	's	PART
biomedich-399	98	17	and	and	CCONJ
biomedich-399	98	18	veber	veber	PROPN
biomedich-399	98	19	’s	’s	PART
biomedich-399	98	20	rules	rule	NOUN
biomedich-399	98	21	,	,	PUNCT
biomedich-399	98	22	fulfilling	fulfil	VERB
biomedich-399	98	23	strong	strong	ADJ
biomedich-399	98	24	physicochemical	physicochemical	ADJ
biomedich-399	98	25	requirements	requirement	NOUN
biomedich-399	98	26	(	(	PUNCT
biomedich-399	98	27	table	table	NOUN
biomedich-399	98	28	3	3	NUM
biomedich-399	98	29	)	)	PUNCT
biomedich-399	98	30	as	as	ADP
biomedich-399	98	31	a	a	DET
biomedich-399	98	32	potential	potential	ADJ
biomedich-399	98	33	drug	drug	NOUN
biomedich-399	98	34	.	.	PUNCT
biomedich-399	99	1	also	also	ADV
biomedich-399	99	2	(	(	PUNCT
biomedich-399	99	3	-)catechin	-)catechin	X
biomedich-399	99	4	shows	show	VERB
biomedich-399	99	5	a	a	DET
biomedich-399	99	6	satisfactory	satisfactory	ADJ
biomedich-399	99	7	percentage	percentage	NOUN
biomedich-399	99	8	of	of	ADP
biomedich-399	99	9	absorption	absorption	NOUN
biomedich-399	99	10	through	through	ADP
biomedich-399	99	11	the	the	DET
biomedich-399	99	12	human	human	ADJ
biomedich-399	99	13	intestinal	intestinal	ADJ
biomedich-399	99	14	tract	tract	NOUN
biomedich-399	99	15	.	.	PUNCT
biomedich-399	100	1	another	another	DET
biomedich-399	100	2	important	important	ADJ
biomedich-399	100	3	characteristic	characteristic	NOUN
biomedich-399	100	4	is	be	AUX
biomedich-399	100	5	that	that	SCONJ
biomedich-399	100	6	all	all	DET
biomedich-399	100	7	the	the	DET
biomedich-399	100	8	screened	screen	VERB
biomedich-399	100	9	phytochemicals	phytochemical	NOUN
biomedich-399	100	10	from	from	ADP
biomedich-399	100	11	grape	grape	NOUN
biomedich-399	100	12	seed	seed	NOUN
biomedich-399	100	13	extract	extract	NOUN
biomedich-399	100	14	do	do	AUX
biomedich-399	100	15	n't	not	PART
biomedich-399	100	16	show	show	VERB
biomedich-399	100	17	hepatotoxicity	hepatotoxicity	NOUN
biomedich-399	100	18	(	(	PUNCT
biomedich-399	100	19	table	table	NOUN
biomedich-399	100	20	2	2	NUM
biomedich-399	100	21	)	)	PUNCT
biomedich-399	100	22	,	,	PUNCT
biomedich-399	100	23	even	even	ADV
biomedich-399	100	24	though	though	SCONJ
biomedich-399	100	25	the	the	DET
biomedich-399	100	26	well	well	ADV
biomedich-399	100	27	-	-	PUNCT
biomedich-399	100	28	known	know	VERB
biomedich-399	100	29	commercially	commercially	ADV
biomedich-399	100	30	available	available	ADJ
biomedich-399	100	31	antibiotic	antibiotic	ADJ
biomedich-399	100	32	ciprofloxacin	ciprofloxacin	NOUN
biomedich-399	100	33	shows	show	VERB
biomedich-399	100	34	some	some	DET
biomedich-399	100	35	level	level	NOUN
biomedich-399	100	36	of	of	ADP
biomedich-399	100	37	hepatotoxicity	hepatotoxicity	NOUN
biomedich-399	100	38	.	.	PUNCT
biomedich-399	101	1	in	in	ADP
biomedich-399	101	2	pharmacokinetics	pharmacokinetic	NOUN
biomedich-399	101	3	and	and	CCONJ
biomedich-399	101	4	toxicity	toxicity	NOUN
biomedich-399	101	5	analysis	analysis	NOUN
biomedich-399	101	6	,	,	PUNCT
biomedich-399	101	7	it	it	PRON
biomedich-399	101	8	is	be	AUX
biomedich-399	101	9	categorized	categorize	VERB
biomedich-399	101	10	that	that	SCONJ
biomedich-399	101	11	values	value	NOUN
biomedich-399	101	12	between	between	ADP
biomedich-399	101	13	-4	-4	PUNCT
biomedich-399	101	14	and	and	CCONJ
biomedich-399	101	15	-2	-2	INTJ
biomedich-399	101	16	log	log	VERB
biomedich-399	101	17	mol	mol	PROPN
biomedich-399	101	18	/	/	SYM
biomedich-399	101	19	l	l	NOUN
biomedich-399	101	20	as	as	ADP
biomedich-399	101	21	water	water	NOUN
biomedich-399	101	22	“	"	PUNCT
biomedich-399	101	23	soluble	soluble	ADJ
biomedich-399	101	24	“	"	PUNCT
biomedich-399	101	25	compounds	compound	NOUN
biomedich-399	101	26	.	.	PUNCT
biomedich-399	102	1	interestingly	interestingly	ADV
biomedich-399	102	2	all	all	DET
biomedich-399	102	3	the	the	DET
biomedich-399	102	4	compounds	compound	NOUN
biomedich-399	102	5	examined	examine	VERB
biomedich-399	102	6	are	be	AUX
biomedich-399	102	7	coming	come	VERB
biomedich-399	102	8	under	under	ADP
biomedich-399	102	9	that	that	DET
biomedich-399	102	10	category	category	NOUN
biomedich-399	102	11	.	.	PUNCT
biomedich-399	103	1	out	out	ADP
biomedich-399	103	2	of	of	ADP
biomedich-399	103	3	the	the	DET
biomedich-399	103	4	phytochemical	phytochemical	NOUN
biomedich-399	103	5	from	from	ADP
biomedich-399	103	6	the	the	DET
biomedich-399	103	7	grape	grape	NOUN
biomedich-399	103	8	seed	seed	NOUN
biomedich-399	103	9	extract	extract	NOUN
biomedich-399	103	10	assessed	assess	VERB
biomedich-399	103	11	,	,	PUNCT
biomedich-399	103	12	no	no	DET
biomedich-399	103	13	chemical	chemical	NOUN
biomedich-399	103	14	acted	act	VERB
biomedich-399	103	15	as	as	ADP
biomedich-399	103	16	a	a	DET
biomedich-399	103	17	substrate	substrate	NOUN
biomedich-399	103	18	for	for	ADP
biomedich-399	103	19	cytochromes	cytochrome	NOUN
biomedich-399	103	20	p450	p450	NUM
biomedich-399	103	21	isozymes	isozyme	NOUN
biomedich-399	103	22	but	but	CCONJ
biomedich-399	103	23	the	the	DET
biomedich-399	103	24	reference	reference	NOUN
biomedich-399	103	25	antibiotic	antibiotic	ADJ
biomedich-399	103	26	.	.	PUNCT
biomedich-399	104	1	however	however	ADV
biomedich-399	104	2	,	,	PUNCT
biomedich-399	104	3	predicted	predict	VERB
biomedich-399	104	4	data	datum	NOUN
biomedich-399	104	5	revealed	reveal	VERB
biomedich-399	104	6	that	that	SCONJ
biomedich-399	104	7	epicatechin-3gallate	epicatechin-3gallate	NOUN
biomedich-399	104	8	and	and	CCONJ
biomedich-399	104	9	quercetin	quercetin	NOUN
biomedich-399	104	10	have	have	VERB
biomedich-399	104	11	the	the	DET
biomedich-399	104	12	potential	potential	NOUN
biomedich-399	104	13	to	to	PART
biomedich-399	104	14	inhibit	inhibit	VERB
biomedich-399	104	15	cyp1a2	cyp1a2	ADJ
biomedich-399	104	16	isozyme	isozyme	NOUN
biomedich-399	104	17	.	.	PUNCT
biomedich-399	105	1	conclusions	conclusion	NOUN
biomedich-399	105	2	selected	select	VERB
biomedich-399	105	3	secondary	secondary	ADJ
biomedich-399	105	4	metabolites	metabolite	NOUN
biomedich-399	105	5	found	find	VERB
biomedich-399	105	6	in	in	ADP
biomedich-399	105	7	grape	grape	NOUN
biomedich-399	105	8	seed	seed	NOUN
biomedich-399	105	9	extract	extract	NOUN
biomedich-399	105	10	were	be	AUX
biomedich-399	105	11	tested	test	VERB
biomedich-399	105	12	in	in	ADP
biomedich-399	105	13	silico	silico	NOUN
biomedich-399	105	14	for	for	ADP
biomedich-399	105	15	their	their	PRON
biomedich-399	105	16	potential	potential	ADJ
biomedich-399	105	17	inhibitory	inhibitory	ADJ
biomedich-399	105	18	action	action	NOUN
biomedich-399	105	19	towards	towards	ADP
biomedich-399	105	20	dna	dna	PROPN
biomedich-399	105	21	gyrase	gyrase	NOUN
biomedich-399	105	22	enzyme	enzyme	NOUN
biomedich-399	105	23	,	,	PUNCT
biomedich-399	105	24	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	105	25	and	and	CCONJ
biomedich-399	105	26	physicochemical	physicochemical	ADJ
biomedich-399	105	27	properties	property	NOUN
biomedich-399	105	28	,	,	PUNCT
biomedich-399	105	29	and	and	CCONJ
biomedich-399	105	30	compared	compare	VERB
biomedich-399	105	31	with	with	ADP
biomedich-399	105	32	the	the	DET
biomedich-399	105	33	commercial	commercial	ADJ
biomedich-399	105	34	antibiotic	antibiotic	NOUN
biomedich-399	105	35	,	,	PUNCT
biomedich-399	105	36	ciprofloxacin	ciprofloxacin	PROPN
biomedich-399	105	37	.	.	PUNCT
biomedich-399	106	1	out	out	ADP
biomedich-399	106	2	of	of	ADP
biomedich-399	106	3	the	the	DET
biomedich-399	106	4	tenphytochemical	tenphytochemical	NOUN
biomedich-399	106	5	assessed	assess	VERB
biomedich-399	106	6	,	,	PUNCT
biomedich-399	106	7	(	(	PUNCT
biomedich-399	106	8	-)-catechin	-)-catechin	ADJ
biomedich-399	106	9	and	and	CCONJ
biomedich-399	106	10	procyanidin	procyanidin	NOUN
biomedich-399	106	11	-	-	PUNCT
biomedich-399	106	12	b2	b2	NOUN
biomedich-399	106	13	indicated	indicate	VERB
biomedich-399	106	14	the	the	DET
biomedich-399	106	15	best	good	ADJ
biomedich-399	106	16	receptor	receptor	NOUN
biomedich-399	106	17	inhibition	inhibition	NOUN
biomedich-399	106	18	capabilities	capability	NOUN
biomedich-399	106	19	.	.	PUNCT
biomedich-399	107	1	comprehensive	comprehensive	ADJ
biomedich-399	107	2	docking	docking	NOUN
biomedich-399	107	3	,	,	PUNCT
biomedich-399	107	4	pharmacokinetic	pharmacokinetic	ADJ
biomedich-399	107	5	,	,	PUNCT
biomedich-399	107	6	and	and	CCONJ
biomedich-399	107	7	physicochemical	physicochemical	ADJ
biomedich-399	107	8	tests	test	NOUN
biomedich-399	107	9	indicated	indicate	VERB
biomedich-399	107	10	that	that	SCONJ
biomedich-399	107	11	(	(	PUNCT
biomedich-399	107	12	-)-catechin	-)-catechin	PUNCT
biomedich-399	107	13	would	would	AUX
biomedich-399	107	14	be	be	AUX
biomedich-399	107	15	a	a	DET
biomedich-399	107	16	viable	viable	ADJ
biomedich-399	107	17	dna	dna	NOUN
biomedich-399	107	18	gyrase	gyrase	NOUN
biomedich-399	107	19	b	b	NOUN
biomedich-399	107	20	inhibitor	inhibitor	NOUN
biomedich-399	107	21	because	because	SCONJ
biomedich-399	107	22	it	it	PRON
biomedich-399	107	23	binds	bind	VERB
biomedich-399	107	24	firmly	firmly	ADV
biomedich-399	107	25	to	to	ADP
biomedich-399	107	26	the	the	DET
biomedich-399	107	27	binding	bind	VERB
biomedich-399	107	28	pocket	pocket	NOUN
biomedich-399	107	29	,	,	PUNCT
biomedich-399	107	30	inhibiting	inhibit	VERB
biomedich-399	107	31	the	the	DET
biomedich-399	107	32	native	native	ADJ
biomedich-399	107	33	conformation	conformation	NOUN
biomedich-399	107	34	of	of	ADP
biomedich-399	107	35	the	the	DET
biomedich-399	107	36	protein	protein	NOUN
biomedich-399	107	37	.	.	PUNCT
biomedich-399	108	1	hence	hence	ADV
biomedich-399	108	2	,	,	PUNCT
biomedich-399	108	3	(	(	PUNCT
biomedich-399	108	4	-)-catechin	-)-catechin	X
biomedich-399	108	5	is	be	AUX
biomedich-399	108	6	an	an	DET
biomedich-399	108	7	exceptional	exceptional	ADJ
biomedich-399	108	8	candidate	candidate	NOUN
biomedich-399	108	9	for	for	ADP
biomedich-399	108	10	further	far	ADV
biomedich-399	108	11	in	in	ADP
biomedich-399	108	12	vitro	vitro	NOUN
biomedich-399	108	13	/	/	SYM
biomedich-399	108	14	in	in	ADP
biomedich-399	108	15	vivo	vivo	ADJ
biomedich-399	108	16	studies	study	NOUN
biomedich-399	108	17	.	.	PUNCT
biomedich-399	109	1	authors	author	NOUN
biomedich-399	109	2	’	’	PART
biomedich-399	109	3	contributions	contribution	NOUN
biomedich-399	109	4	:	:	PUNCT
biomedich-399	109	5	p.l.m.j.h	p.l.m.j.h	NOUN
biomedich-399	109	6	.	.	PUNCT
biomedich-399	110	1	lawan	lawan	PROPN
biomedich-399	110	2	and	and	CCONJ
biomedich-399	110	3	d.h	d.h	PROPN
biomedich-399	110	4	.	.	PROPN
biomedich-399	110	5	tharakee	tharakee	PROPN
biomedich-399	110	6	designed	design	VERB
biomedich-399	110	7	the	the	DET
biomedich-399	110	8	study	study	NOUN
biomedich-399	110	9	,	,	PUNCT
biomedich-399	110	10	carried	carry	VERB
biomedich-399	110	11	out	out	ADP
biomedich-399	110	12	computational	computational	ADJ
biomedich-399	110	13	studies	study	NOUN
biomedich-399	110	14	,	,	PUNCT
biomedich-399	110	15	and	and	CCONJ
biomedich-399	110	16	analyzed	analyze	VERB
biomedich-399	110	17	the	the	DET
biomedich-399	110	18	data	datum	NOUN
biomedich-399	110	19	.	.	PUNCT
biomedich-399	111	1	p.l.m.j.h	p.l.m.j.h	NOUN
biomedich-399	111	2	.	.	PUNCT
biomedich-399	112	1	lawan	lawan	PROPN
biomedich-399	112	2	and	and	CCONJ
biomedich-399	112	3	d.h	d.h	PROPN
biomedich-399	112	4	.	.	PROPN
biomedich-399	112	5	tharakee	tharakee	PROPN
biomedich-399	112	6	wrote	write	VERB
biomedich-399	112	7	the	the	DET
biomedich-399	112	8	manuscript	manuscript	NOUN
biomedich-399	112	9	.	.	PUNCT
biomedich-399	113	1	all	all	DET
biomedich-399	113	2	authors	author	NOUN
biomedich-399	113	3	read	read	VERB
biomedich-399	113	4	and	and	CCONJ
biomedich-399	113	5	approved	approve	VERB
biomedich-399	113	6	the	the	DET
biomedich-399	113	7	final	final	ADJ
biomedich-399	113	8	version	version	NOUN
biomedich-399	113	9	of	of	ADP
biomedich-399	113	10	the	the	DET
biomedich-399	113	11	manuscript	manuscript	NOUN
biomedich-399	113	12	.	.	PUNCT
biomedich-399	114	1	competing	compete	VERB
biomedich-399	114	2	interests	interest	NOUN
biomedich-399	114	3	:	:	PUNCT
biomedich-399	114	4	the	the	DET
biomedich-399	114	5	authors	author	NOUN
biomedich-399	114	6	declare	declare	VERB
biomedich-399	114	7	that	that	SCONJ
biomedich-399	114	8	there	there	PRON
biomedich-399	114	9	are	be	VERB
biomedich-399	114	10	no	no	DET
biomedich-399	114	11	competing	compete	VERB
biomedich-399	114	12	interests	interest	NOUN
biomedich-399	114	13	.	.	PUNCT
biomedich-399	115	1	references	reference	NOUN
biomedich-399	115	2	brown	brown	PROPN
biomedich-399	115	3	,	,	PUNCT
biomedich-399	115	4	j.	j.	PROPN
biomedich-399	115	5	c.	c.	PROPN
biomedich-399	115	6	,	,	PUNCT
biomedich-399	115	7	huang	huang	PROPN
biomedich-399	115	8	,	,	PUNCT
biomedich-399	115	9	g.	g.	PROPN
biomedich-399	115	10	,	,	PUNCT
biomedich-399	115	11	haley	haley	NOUN
biomedich-399	115	12	-	-	PUNCT
biomedich-399	115	13	zitlin	zitlin	PROPN
biomedich-399	115	14	,	,	PUNCT
biomedich-399	115	15	v.	v.	PROPN
biomedich-399	115	16	,	,	PUNCT
biomedich-399	115	17	&	&	CCONJ
biomedich-399	115	18	jiang	jiang	PROPN
biomedich-399	115	19	,	,	PUNCT
biomedich-399	115	20	x.	x.	NOUN
biomedich-399	115	21	(	(	PUNCT
biomedich-399	115	22	2009	2009	NUM
biomedich-399	115	23	)	)	PUNCT
biomedich-399	115	24	.	.	PUNCT
biomedich-399	116	1	antibacterial	antibacterial	ADJ
biomedich-399	116	2	effects	effect	NOUN
biomedich-399	116	3	of	of	ADP
biomedich-399	116	4	grape	grape	NOUN
biomedich-399	116	5	extracts	extract	NOUN
biomedich-399	116	6	on	on	ADP
biomedich-399	116	7	helicobacter	helicobacter	NOUN
biomedich-399	116	8	pylori	pylori	NOUN
biomedich-399	116	9	.	.	PUNCT
biomedich-399	117	1	applied	apply	VERB
biomedich-399	117	2	and	and	CCONJ
biomedich-399	117	3	environmental	environmental	ADJ
biomedich-399	117	4	microbiology	microbiology	NOUN
biomedich-399	117	5	,	,	PUNCT
biomedich-399	117	6	75(3	75(3	NUM
biomedich-399	117	7	)	)	PUNCT
biomedich-399	117	8	,	,	PUNCT
biomedich-399	117	9	848–852	848–852	NUM
biomedich-399	117	10	.	.	PUNCT
biomedich-399	118	1	https://doi.org/10.1128/aem.01595-08	https://doi.org/10.1128/aem.01595-08	NOUN
biomedich-399	118	2	drlica	drlica	PROPN
biomedich-399	118	3	,	,	PUNCT
biomedich-399	118	4	k.	k.	PROPN
biomedich-399	118	5	,	,	PUNCT
biomedich-399	118	6	malik	malik	PROPN
biomedich-399	118	7	,	,	PUNCT
biomedich-399	118	8	m.	m.	NOUN
biomedich-399	118	9	,	,	PUNCT
biomedich-399	118	10	kerns	kerns	PROPN
biomedich-399	118	11	,	,	PUNCT
biomedich-399	118	12	r.	r.	PROPN
biomedich-399	118	13	j.	j.	PROPN
biomedich-399	118	14	,	,	PUNCT
biomedich-399	118	15	&	&	CCONJ
biomedich-399	118	16	zhao	zhao	PROPN
biomedich-399	118	17	,	,	PUNCT
biomedich-399	118	18	x.	x.	NOUN
biomedich-399	118	19	(	(	PUNCT
biomedich-399	118	20	2008	2008	NUM
biomedich-399	118	21	)	)	PUNCT
biomedich-399	118	22	.	.	PUNCT
biomedich-399	118	23	quinolonemediated	quinolonemediate	VERB
biomedich-399	118	24	bacterial	bacterial	ADJ
biomedich-399	118	25	death	death	NOUN
biomedich-399	118	26	.	.	PUNCT
biomedich-399	119	1	antimicrobial	antimicrobial	ADJ
biomedich-399	119	2	agents	agent	NOUN
biomedich-399	119	3	and	and	CCONJ
biomedich-399	119	4	chemotherapy	chemotherapy	NOUN
biomedich-399	119	5	,	,	PUNCT
biomedich-399	119	6	52(2	52(2	NUM
biomedich-399	119	7	)	)	PUNCT
biomedich-399	119	8	,	,	PUNCT
biomedich-399	119	9	385–392	385–392	NUM
biomedich-399	119	10	.	.	PUNCT
biomedich-399	120	1	https://doi.org/10.1128/aac.01617-06	https://doi.org/10.1128/aac.01617-06	ADJ
biomedich-399	120	2	georgiev	georgiev	NOUN
biomedich-399	120	3	,	,	PUNCT
biomedich-399	120	4	v.	v.	ADV
biomedich-399	120	5	,	,	PUNCT
biomedich-399	120	6	ananga	ananga	ADP
biomedich-399	120	7	,	,	PUNCT
biomedich-399	120	8	a.	a.	NOUN
biomedich-399	120	9	,	,	PUNCT
biomedich-399	120	10	&	&	CCONJ
biomedich-399	120	11	tsolova	tsolova	PROPN
biomedich-399	120	12	,	,	PUNCT
biomedich-399	120	13	v.	v.	PROPN
biomedich-399	120	14	(	(	PUNCT
biomedich-399	120	15	2014	2014	NUM
biomedich-399	120	16	)	)	PUNCT
biomedich-399	120	17	.	.	PUNCT
biomedich-399	121	1	recent	recent	ADJ
biomedich-399	121	2	advances	advance	NOUN
biomedich-399	121	3	and	and	CCONJ
biomedich-399	121	4	uses	use	NOUN
biomedich-399	121	5	of	of	ADP
biomedich-399	121	6	grape	grape	NOUN
biomedich-399	121	7	flavonoids	flavonoid	NOUN
biomedich-399	121	8	as	as	ADP
biomedich-399	121	9	nutraceuticals	nutraceutical	NOUN
biomedich-399	121	10	.	.	PUNCT
biomedich-399	122	1	nutrients	nutrient	NOUN
biomedich-399	122	2	,	,	PUNCT
biomedich-399	122	3	6(1	6(1	NUM
biomedich-399	122	4	)	)	PUNCT
biomedich-399	122	5	,	,	PUNCT
biomedich-399	122	6	391–415	391–415	NUM
biomedich-399	122	7	.	.	PUNCT
biomedich-399	123	1	https://doi.org/10.3390/nu6010391	https://doi.org/10.3390/nu6010391	ADJ
biomedich-399	123	2	jayaprakasha	jayaprakasha	PROPN
biomedich-399	123	3	,	,	PUNCT
biomedich-399	123	4	g.	g.	PROPN
biomedich-399	123	5	k.	k.	PROPN
biomedich-399	123	6	,	,	PUNCT
biomedich-399	123	7	selvi	selvi	PROPN
biomedich-399	123	8	,	,	PUNCT
biomedich-399	123	9	t.	t.	PROPN
biomedich-399	123	10	,	,	PUNCT
biomedich-399	123	11	&	&	CCONJ
biomedich-399	123	12	sakariah	sakariah	PROPN
biomedich-399	123	13	,	,	PUNCT
biomedich-399	123	14	k.	k.	PROPN
biomedich-399	123	15	k.	k.	PROPN
biomedich-399	123	16	(	(	PUNCT
biomedich-399	123	17	2003	2003	NUM
biomedich-399	123	18	)	)	PUNCT
biomedich-399	123	19	.	.	PUNCT
biomedich-399	124	1	antibacterial	antibacterial	ADJ
biomedich-399	124	2	and	and	CCONJ
biomedich-399	124	3	antioxidant	antioxidant	ADJ
biomedich-399	124	4	activities	activity	NOUN
biomedich-399	124	5	of	of	ADP
biomedich-399	124	6	grape	grape	NOUN
biomedich-399	124	7	(	(	PUNCT
biomedich-399	124	8	vitis	vitis	ADJ
biomedich-399	124	9	vinifera	vinifera	NOUN
biomedich-399	124	10	)	)	PUNCT
biomedich-399	124	11	seed	seed	NOUN
biomedich-399	124	12	extracts	extract	NOUN
biomedich-399	124	13	.	.	PUNCT
biomedich-399	125	1	food	food	NOUN
biomedich-399	125	2	research	research	PROPN
biomedich-399	125	3	international	international	PROPN
biomedich-399	125	4	,	,	PUNCT
biomedich-399	125	5	36(2	36(2	NUM
biomedich-399	125	6	)	)	PUNCT
biomedich-399	125	7	,	,	PUNCT
biomedich-399	125	8	117–122	117–122	NUM
biomedich-399	125	9	.	.	PUNCT
biomedich-399	125	10	https://doi.org/10.1016/s0963-9969(02)00116-3	https://doi.org/10.1016/s0963-9969(02)00116-3	PROPN
biomedich-399	125	11	kim	kim	PROPN
biomedich-399	125	12	,	,	PUNCT
biomedich-399	125	13	t.	t.	PROPN
biomedich-399	125	14	h.	h.	PROPN
biomedich-399	125	15	,	,	PUNCT
biomedich-399	125	16	jeon	jeon	PROPN
biomedich-399	125	17	,	,	PUNCT
biomedich-399	125	18	e.	e.	PROPN
biomedich-399	125	19	j.	j.	PROPN
biomedich-399	125	20	,	,	PUNCT
biomedich-399	125	21	cheung	cheung	PROPN
biomedich-399	125	22	,	,	PUNCT
biomedich-399	125	23	d.	d.	PROPN
biomedich-399	125	24	y.	y.	PROPN
biomedich-399	125	25	,	,	PUNCT
biomedich-399	125	26	kim	kim	PROPN
biomedich-399	125	27	,	,	PUNCT
biomedich-399	125	28	c.	c.	PROPN
biomedich-399	125	29	w.	w.	PROPN
biomedich-399	125	30	,	,	PUNCT
biomedich-399	125	31	kim	kim	PROPN
biomedich-399	125	32	,	,	PUNCT
biomedich-399	125	33	s.	s.	PROPN
biomedich-399	125	34	s.	s.	PROPN
biomedich-399	125	35	,	,	PUNCT
biomedich-399	125	36	park	park	NOUN
biomedich-399	125	37	,	,	PUNCT
biomedich-399	125	38	s.-h	s.-h	NOUN
biomedich-399	125	39	.	.	PROPN
biomedich-399	125	40	,	,	PUNCT
biomedich-399	125	41	han	han	PROPN
biomedich-399	125	42	,	,	PUNCT
biomedich-399	125	43	s.	s.	PROPN
biomedich-399	125	44	w.	w.	PROPN
biomedich-399	125	45	,	,	PUNCT
biomedich-399	125	46	kim	kim	PROPN
biomedich-399	125	47	,	,	PUNCT
biomedich-399	125	48	m.	m.	PROPN
biomedich-399	125	49	j.	j.	PROPN
biomedich-399	125	50	,	,	PUNCT
biomedich-399	125	51	lee	lee	PROPN
biomedich-399	125	52	,	,	PUNCT
biomedich-399	125	53	y.	y.	PROPN
biomedich-399	125	54	s.	s.	PROPN
biomedich-399	125	55	,	,	PUNCT
biomedich-399	125	56	cho	cho	PROPN
biomedich-399	125	57	,	,	PUNCT
biomedich-399	125	58	m.-l	m.-l	PROPN
biomedich-399	125	59	.	.	PUNCT
biomedich-399	125	60	,	,	PUNCT
biomedich-399	125	61	chang	chang	PROPN
biomedich-399	125	62	,	,	PUNCT
biomedich-399	125	63	j.	j.	PROPN
biomedich-399	125	64	h.	h.	PROPN
biomedich-399	125	65	,	,	PUNCT
biomedich-399	125	66	min	min	PROPN
biomedich-399	125	67	,	,	PUNCT
biomedich-399	125	68	j.	j.	PROPN
biomedich-399	125	69	k.	k.	PROPN
biomedich-399	125	70	,	,	PUNCT
biomedich-399	125	71	&	&	CCONJ
biomedich-399	125	72	kim	kim	PROPN
biomedich-399	125	73	,	,	PUNCT
biomedich-399	125	74	j.	j.	PROPN
biomedich-399	125	75	il	il	PROPN
biomedich-399	125	76	.	.	PROPN
biomedich-399	125	77	(	(	PUNCT
biomedich-399	125	78	2013	2013	NUM
biomedich-399	125	79	)	)	PUNCT
biomedich-399	125	80	.	.	PUNCT
biomedich-399	126	1	gastroprotective	gastroprotective	NOUN
biomedich-399	126	2	effects	effect	NOUN
biomedich-399	126	3	of	of	ADP
biomedich-399	126	4	grape	grape	NOUN
biomedich-399	126	5	seed	seed	NOUN
biomedich-399	126	6	proanthocyanidin	proanthocyanidin	VERB
biomedich-399	126	7	extracts	extract	NOUN
biomedich-399	126	8	against	against	ADP
biomedich-399	126	9	nonsteroid	nonsteroid	PROPN
biomedich-399	126	10	anti	anti	ADJ
biomedich-399	126	11	-	-	ADJ
biomedich-399	126	12	inflammatory	inflammatory	ADJ
biomedich-399	126	13	drug	drug	NOUN
biomedich-399	126	14	-	-	PUNCT
biomedich-399	126	15	induced	induce	VERB
biomedich-399	126	16	gastric	gastric	ADJ
biomedich-399	126	17	injury	injury	NOUN
biomedich-399	126	18	in	in	ADP
biomedich-399	126	19	rats	rat	NOUN
biomedich-399	126	20	.	.	PUNCT
biomedich-399	127	1	gut	gut	NOUN
biomedich-399	127	2	and	and	CCONJ
biomedich-399	127	3	liver	liver	NOUN
biomedich-399	127	4	,	,	PUNCT
biomedich-399	127	5	7(3	7(3	NUM
biomedich-399	127	6	)	)	PUNCT
biomedich-399	127	7	,	,	PUNCT
biomedich-399	127	8	282–289	282–289	NUM
biomedich-399	127	9	.	.	PUNCT
biomedich-399	128	1	https://doi.org/10.5009/gnl.2013.7.3.282	https://doi.org/10.5009/gnl.2013.7.3.282	PROPN
biomedich-399	128	2	lipinski	lipinski	PROPN
biomedich-399	128	3	,	,	PUNCT
biomedich-399	128	4	c.	c.	PROPN
biomedich-399	128	5	a.	a.	PROPN
biomedich-399	128	6	,	,	PUNCT
biomedich-399	128	7	lombardo	lombardo	PROPN
biomedich-399	128	8	,	,	PUNCT
biomedich-399	128	9	f.	f.	PROPN
biomedich-399	128	10	,	,	PUNCT
biomedich-399	128	11	dominy	dominy	PROPN
biomedich-399	128	12	,	,	PUNCT
biomedich-399	128	13	b.	b.	PROPN
biomedich-399	128	14	w.	w.	PROPN
biomedich-399	128	15	,	,	PUNCT
biomedich-399	128	16	&	&	CCONJ
biomedich-399	128	17	feeney	feeney	PROPN
biomedich-399	128	18	,	,	PUNCT
biomedich-399	128	19	p.	p.	PROPN
biomedich-399	128	20	j.	j.	PROPN
biomedich-399	128	21	(	(	PUNCT
biomedich-399	128	22	2001	2001	NUM
biomedich-399	128	23	)	)	PUNCT
biomedich-399	128	24	.	.	PUNCT
biomedich-399	129	1	experimental	experimental	ADJ
biomedich-399	129	2	and	and	CCONJ
biomedich-399	129	3	computational	computational	ADJ
biomedich-399	129	4	approaches	approach	NOUN
biomedich-399	129	5	to	to	PART
biomedich-399	129	6	estimate	estimate	VERB
biomedich-399	129	7	solubility	solubility	NOUN
biomedich-399	129	8	and	and	CCONJ
biomedich-399	129	9	permeability	permeability	NOUN
biomedich-399	129	10	in	in	ADP
biomedich-399	129	11	drug	drug	NOUN
biomedich-399	129	12	discovery	discovery	NOUN
biomedich-399	129	13	and	and	CCONJ
biomedich-399	129	14	592	592	NUM
biomedich-399	129	15	biology	biology	NOUN
biomedich-399	129	16	,	,	PUNCT
biomedich-399	129	17	medicine	medicine	NOUN
biomedich-399	129	18	,	,	PUNCT
biomedich-399	129	19	&	&	CCONJ
biomedich-399	129	20	natural	natural	ADJ
biomedich-399	129	21	product	product	NOUN
biomedich-399	129	22	chemistry	chemistry	NOUN
biomedich-399	129	23	12	12	NUM
biomedich-399	129	24	(	(	PUNCT
biomedich-399	129	25	2	2	NUM
biomedich-399	129	26	)	)	PUNCT
biomedich-399	129	27	,	,	PUNCT
biomedich-399	129	28	2023	2023	NUM
biomedich-399	129	29	:	:	PUNCT
biomedich-399	129	30	585	585	NUM
biomedich-399	129	31	-	-	SYM
biomedich-399	129	32	592	592	NUM
biomedich-399	129	33	development	development	NOUN
biomedich-399	129	34	settings	setting	NOUN
biomedich-399	129	35	1pii	1pii	NUM
biomedich-399	129	36	of	of	ADP
biomedich-399	129	37	original	original	ADJ
biomedich-399	129	38	article	article	NOUN
biomedich-399	129	39	:	:	PUNCT
biomedich-399	129	40	s0169409x(96)00423	s0169409x(96)00423	NOUN
biomedich-399	129	41	-	-	SYM
biomedich-399	129	42	1	1	NUM
biomedich-399	129	43	.	.	PUNCT
biomedich-399	130	1	the	the	DET
biomedich-399	130	2	article	article	NOUN
biomedich-399	130	3	was	be	AUX
biomedich-399	130	4	originally	originally	ADV
biomedich-399	130	5	published	publish	VERB
biomedich-399	130	6	in	in	ADP
biomedich-399	130	7	advanced	advanced	ADJ
biomedich-399	130	8	drug	drug	NOUN
biomedich-399	130	9	delivery	delivery	NOUN
biomedich-399	130	10	reviews	review	VERB
biomedich-399	130	11	23	23	NUM
biomedich-399	130	12	(	(	PUNCT
biomedich-399	130	13	1997	1997	NUM
biomedich-399	130	14	)	)	PUNCT
biomedich-399	130	15	3–25	3–25	VERB
biomedich-399	130	16	.	.	PUNCT
biomedich-399	131	1	1	1	NUM
biomedich-399	131	2	.	.	X
biomedich-399	131	3	advanced	advanced	ADJ
biomedich-399	131	4	drug	drug	NOUN
biomedich-399	131	5	delivery	delivery	NOUN
biomedich-399	131	6	reviews	review	NOUN
biomedich-399	131	7	,	,	PUNCT
biomedich-399	131	8	46(1–3	46(1–3	NOUN
biomedich-399	131	9	)	)	PUNCT
biomedich-399	131	10	,	,	PUNCT
biomedich-399	131	11	3–26	3–26	NUM
biomedich-399	131	12	.	.	PUNCT
biomedich-399	132	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
biomedich-399	132	2	maxwell	maxwell	PROPN
biomedich-399	132	3	,	,	PUNCT
biomedich-399	132	4	a.	a.	PROPN
biomedich-399	132	5	,	,	PUNCT
biomedich-399	132	6	&	&	CCONJ
biomedich-399	132	7	lawson	lawson	PROPN
biomedich-399	132	8	,	,	PUNCT
biomedich-399	132	9	d.	d.	PROPN
biomedich-399	132	10	(	(	PUNCT
biomedich-399	132	11	2003	2003	NUM
biomedich-399	132	12	)	)	PUNCT
biomedich-399	132	13	.	.	PUNCT
biomedich-399	133	1	the	the	DET
biomedich-399	133	2	atp	atp	NOUN
biomedich-399	133	3	-	-	PUNCT
biomedich-399	133	4	binding	bind	VERB
biomedich-399	133	5	site	site	NOUN
biomedich-399	133	6	of	of	ADP
biomedich-399	133	7	type	type	NOUN
biomedich-399	133	8	ii	ii	PROPN
biomedich-399	133	9	topoisomerases	topoisomerase	NOUN
biomedich-399	133	10	as	as	ADP
biomedich-399	133	11	a	a	DET
biomedich-399	133	12	target	target	NOUN
biomedich-399	133	13	for	for	ADP
biomedich-399	133	14	antibacterial	antibacterial	ADJ
biomedich-399	133	15	drugs	drug	NOUN
biomedich-399	133	16	.	.	PUNCT
biomedich-399	134	1	current	current	ADJ
biomedich-399	134	2	topics	topic	NOUN
biomedich-399	134	3	in	in	ADP
biomedich-399	134	4	medicinal	medicinal	ADJ
biomedich-399	134	5	chemistry	chemistry	NOUN
biomedich-399	134	6	,	,	PUNCT
biomedich-399	134	7	3(3	3(3	NUM
biomedich-399	134	8	)	)	PUNCT
biomedich-399	134	9	,	,	PUNCT
biomedich-399	134	10	283–303	283–303	NUM
biomedich-399	134	11	.	.	PUNCT
biomedich-399	135	1	https://doi.org/10.2174/1568026033452500	https://doi.org/10.2174/1568026033452500	PROPN
biomedich-399	135	2	melov	melov	PROPN
biomedich-399	135	3	,	,	PUNCT
biomedich-399	135	4	s.	s.	PROPN
biomedich-399	135	5	(	(	PUNCT
biomedich-399	135	6	2002	2002	NUM
biomedich-399	135	7	)	)	PUNCT
biomedich-399	135	8	.	.	PUNCT
biomedich-399	136	1	animal	animal	NOUN
biomedich-399	136	2	models	model	NOUN
biomedich-399	136	3	of	of	ADP
biomedich-399	136	4	oxidative	oxidative	ADJ
biomedich-399	136	5	stress	stress	NOUN
biomedich-399	136	6	,	,	PUNCT
biomedich-399	136	7	aging	aging	NOUN
biomedich-399	136	8	,	,	PUNCT
biomedich-399	136	9	and	and	CCONJ
biomedich-399	136	10	therapeutic	therapeutic	ADJ
biomedich-399	136	11	antioxidant	antioxidant	ADJ
biomedich-399	136	12	interventions	intervention	NOUN
biomedich-399	136	13	.	.	PUNCT
biomedich-399	137	1	the	the	DET
biomedich-399	137	2	international	international	ADJ
biomedich-399	137	3	journal	journal	NOUN
biomedich-399	137	4	of	of	ADP
biomedich-399	137	5	biochemistry	biochemistry	PROPN
biomedich-399	137	6	&	&	CCONJ
biomedich-399	137	7	cell	cell	NOUN
biomedich-399	137	8	biology	biology	NOUN
biomedich-399	137	9	,	,	PUNCT
biomedich-399	137	10	34(11	34(11	NUM
biomedich-399	137	11	)	)	PUNCT
biomedich-399	137	12	,	,	PUNCT
biomedich-399	137	13	1395–1400	1395–1400	NOUN
biomedich-399	137	14	.	.	PUNCT
biomedich-399	138	1	https://doi.org/10.1016/s1357-2725(02)00086-9	https://doi.org/10.1016/s1357-2725(02)00086-9	NOUN
biomedich-399	138	2	rhodes	rhode	NOUN
biomedich-399	138	3	,	,	PUNCT
biomedich-399	138	4	p.	p.	PROPN
biomedich-399	138	5	,	,	PUNCT
biomedich-399	138	6	mitchell	mitchell	PROPN
biomedich-399	138	7	,	,	PUNCT
biomedich-399	138	8	j.	j.	PROPN
biomedich-399	138	9	,	,	PUNCT
biomedich-399	138	10	wilson	wilson	PROPN
biomedich-399	138	11	,	,	PUNCT
biomedich-399	138	12	m.	m.	NOUN
biomedich-399	138	13	,	,	PUNCT
biomedich-399	138	14	&	&	CCONJ
biomedich-399	138	15	melton	melton	PROPN
biomedich-399	138	16	,	,	PUNCT
biomedich-399	138	17	l.	l.	PROPN
biomedich-399	138	18	(	(	PUNCT
biomedich-399	138	19	2006	2006	NUM
biomedich-399	138	20	)	)	PUNCT
biomedich-399	138	21	.	.	PUNCT
biomedich-399	139	1	antilisterial	antilisterial	ADJ
biomedich-399	139	2	activity	activity	NOUN
biomedich-399	139	3	of	of	ADP
biomedich-399	139	4	grape	grape	NOUN
biomedich-399	139	5	juice	juice	NOUN
biomedich-399	139	6	and	and	CCONJ
biomedich-399	139	7	grape	grape	NOUN
biomedich-399	139	8	extracts	extract	NOUN
biomedich-399	139	9	derived	derive	VERB
biomedich-399	139	10	from	from	ADP
biomedich-399	139	11	vitis	vitis	ADJ
biomedich-399	139	12	vinifera	vinifera	NOUN
biomedich-399	139	13	variety	variety	NOUN
biomedich-399	139	14	ribier	ribier	NOUN
biomedich-399	139	15	.	.	PUNCT
biomedich-399	140	1	international	international	ADJ
biomedich-399	140	2	journal	journal	PROPN
biomedich-399	140	3	of	of	ADP
biomedich-399	140	4	food	food	NOUN
biomedich-399	140	5	microbiology	microbiology	NOUN
biomedich-399	140	6	,	,	PUNCT
biomedich-399	140	7	107(3	107(3	NUM
biomedich-399	140	8	)	)	PUNCT
biomedich-399	140	9	,	,	PUNCT
biomedich-399	140	10	281–286	281–286	NUM
biomedich-399	140	11	.	.	PUNCT
biomedich-399	141	1	https://doi.org/10.1016/j.ijfoodmicro.2005.10.022	https://doi.org/10.1016/j.ijfoodmicro.2005.10.022	NOUN
biomedich-399	141	2	rodríguez	rodríguez	NOUN
biomedich-399	141	3	montealegre	montealegre	PROPN
biomedich-399	141	4	,	,	PUNCT
biomedich-399	141	5	r.	r.	PROPN
biomedich-399	141	6	,	,	PUNCT
biomedich-399	141	7	romero	romero	PROPN
biomedich-399	141	8	peces	peces	PROPN
biomedich-399	141	9	,	,	PUNCT
biomedich-399	141	10	r.	r.	PROPN
biomedich-399	141	11	,	,	PUNCT
biomedich-399	141	12	chacón	chacón	PROPN
biomedich-399	141	13	vozmediano	vozmediano	PROPN
biomedich-399	141	14	,	,	PUNCT
biomedich-399	141	15	j.	j.	PROPN
biomedich-399	141	16	l.	l.	PROPN
biomedich-399	141	17	,	,	PUNCT
biomedich-399	141	18	martínez	martínez	PROPN
biomedich-399	141	19	gascueña	gascueña	PROPN
biomedich-399	141	20	,	,	PUNCT
biomedich-399	141	21	j.	j.	PROPN
biomedich-399	141	22	,	,	PUNCT
biomedich-399	141	23	&	&	CCONJ
biomedich-399	141	24	garcía	garcía	PROPN
biomedich-399	141	25	romero	romero	PROPN
biomedich-399	141	26	,	,	PUNCT
biomedich-399	141	27	e.	e.	PROPN
biomedich-399	141	28	(	(	PUNCT
biomedich-399	141	29	2006	2006	NUM
biomedich-399	141	30	)	)	PUNCT
biomedich-399	141	31	.	.	PUNCT
biomedich-399	142	1	phenolic	phenolic	ADJ
biomedich-399	142	2	compounds	compound	NOUN
biomedich-399	142	3	in	in	ADP
biomedich-399	142	4	skins	skin	NOUN
biomedich-399	142	5	and	and	CCONJ
biomedich-399	142	6	seeds	seed	NOUN
biomedich-399	142	7	of	of	ADP
biomedich-399	142	8	ten	ten	NUM
biomedich-399	142	9	grape	grape	NOUN
biomedich-399	142	10	vitis	vitis	ADJ
biomedich-399	142	11	vinifera	vinifera	NOUN
biomedich-399	142	12	varieties	variety	NOUN
biomedich-399	142	13	grown	grow	VERB
biomedich-399	142	14	in	in	ADP
biomedich-399	142	15	a	a	DET
biomedich-399	142	16	warm	warm	ADJ
biomedich-399	142	17	climate	climate	NOUN
biomedich-399	142	18	.	.	PUNCT
biomedich-399	143	1	journal	journal	NOUN
biomedich-399	143	2	of	of	ADP
biomedich-399	143	3	food	food	NOUN
biomedich-399	143	4	composition	composition	NOUN
biomedich-399	143	5	and	and	CCONJ
biomedich-399	143	6	analysis	analysis	NOUN
biomedich-399	143	7	,	,	PUNCT
biomedich-399	143	8	19(6–7	19(6–7	NUM
biomedich-399	143	9	)	)	PUNCT
biomedich-399	143	10	,	,	PUNCT
biomedich-399	143	11	687–693	687–693	NUM
biomedich-399	143	12	.	.	PUNCT
biomedich-399	144	1	https://doi.org/10.1016/j.jfca.2005.05.003	https://doi.org/10.1016/j.jfca.2005.05.003	ADJ
biomedich-399	144	2	sochorova	sochorova	NOUN
biomedich-399	144	3	,	,	PUNCT
biomedich-399	144	4	l.	l.	PROPN
biomedich-399	144	5	,	,	PUNCT
biomedich-399	144	6	prusova	prusova	PROPN
biomedich-399	144	7	,	,	PUNCT
biomedich-399	144	8	b.	b.	PROPN
biomedich-399	144	9	,	,	PUNCT
biomedich-399	144	10	cebova	cebova	PROPN
biomedich-399	144	11	,	,	PUNCT
biomedich-399	144	12	m.	m.	NOUN
biomedich-399	144	13	,	,	PUNCT
biomedich-399	144	14	jurikova	jurikova	PROPN
biomedich-399	144	15	,	,	PUNCT
biomedich-399	144	16	t.	t.	PROPN
biomedich-399	144	17	,	,	PUNCT
biomedich-399	144	18	mlcek	mlcek	PROPN
biomedich-399	144	19	,	,	PUNCT
biomedich-399	144	20	j.	j.	PROPN
biomedich-399	144	21	,	,	PUNCT
biomedich-399	144	22	adamkova	adamkova	PROPN
biomedich-399	144	23	,	,	PUNCT
biomedich-399	144	24	a.	a.	PROPN
biomedich-399	144	25	,	,	PUNCT
biomedich-399	144	26	nedomova	nedomova	PROPN
biomedich-399	144	27	,	,	PUNCT
biomedich-399	144	28	s.	s.	PROPN
biomedich-399	144	29	,	,	PUNCT
biomedich-399	144	30	baron	baron	NOUN
biomedich-399	144	31	,	,	PUNCT
biomedich-399	144	32	m.	m.	NOUN
biomedich-399	144	33	,	,	PUNCT
biomedich-399	144	34	&	&	CCONJ
biomedich-399	144	35	sochor	sochor	PROPN
biomedich-399	144	36	,	,	PUNCT
biomedich-399	144	37	j.	j.	PROPN
biomedich-399	144	38	(	(	PUNCT
biomedich-399	144	39	2020	2020	NUM
biomedich-399	144	40	)	)	PUNCT
biomedich-399	144	41	.	.	PUNCT
biomedich-399	145	1	health	health	NOUN
biomedich-399	145	2	effects	effect	NOUN
biomedich-399	145	3	of	of	ADP
biomedich-399	145	4	grape	grape	NOUN
biomedich-399	145	5	seed	seed	NOUN
biomedich-399	145	6	and	and	CCONJ
biomedich-399	145	7	skin	skin	NOUN
biomedich-399	145	8	extracts	extract	NOUN
biomedich-399	145	9	and	and	CCONJ
biomedich-399	145	10	their	their	PRON
biomedich-399	145	11	influence	influence	NOUN
biomedich-399	145	12	on	on	ADP
biomedich-399	145	13	biochemical	biochemical	ADJ
biomedich-399	145	14	markers	marker	NOUN
biomedich-399	145	15	.	.	PUNCT
biomedich-399	146	1	molecules	molecule	NOUN
biomedich-399	146	2	,	,	PUNCT
biomedich-399	146	3	25(22	25(22	NOUN
biomedich-399	146	4	)	)	PUNCT
biomedich-399	146	5	,	,	PUNCT
biomedich-399	146	6	5311	5311	NUM
biomedich-399	146	7	.	.	PUNCT
biomedich-399	147	1	https://doi.org/10.3390/molecules25225311	https://doi.org/10.3390/molecules25225311	PROPN
biomedich-399	147	2	subramanian	subramanian	PROPN
biomedich-399	147	3	,	,	PUNCT
biomedich-399	147	4	m.	m.	NOUN
biomedich-399	147	5	,	,	PUNCT
biomedich-399	147	6	goswami	goswami	NOUN
biomedich-399	147	7	,	,	PUNCT
biomedich-399	147	8	m.	m.	NOUN
biomedich-399	147	9	,	,	PUNCT
biomedich-399	147	10	chakraborty	chakraborty	PROPN
biomedich-399	147	11	,	,	PUNCT
biomedich-399	147	12	s.	s.	PROPN
biomedich-399	147	13	,	,	PUNCT
biomedich-399	147	14	&	&	CCONJ
biomedich-399	147	15	jawali	jawali	PROPN
biomedich-399	147	16	,	,	PUNCT
biomedich-399	147	17	n.	n.	PROPN
biomedich-399	147	18	(	(	PUNCT
biomedich-399	147	19	2014	2014	NUM
biomedich-399	147	20	)	)	PUNCT
biomedich-399	147	21	.	.	PUNCT
biomedich-399	148	1	resveratrol	resveratrol	NOUN
biomedich-399	148	2	induced	induce	VERB
biomedich-399	148	3	inhibition	inhibition	NOUN
biomedich-399	148	4	of	of	ADP
biomedich-399	148	5	escherichia	escherichia	NOUN
biomedich-399	148	6	coli	coli	NOUN
biomedich-399	148	7	proceeds	proceed	NOUN
biomedich-399	148	8	via	via	ADP
biomedich-399	148	9	membrane	membrane	NOUN
biomedich-399	148	10	oxidation	oxidation	NOUN
biomedich-399	148	11	and	and	CCONJ
biomedich-399	148	12	independent	independent	ADJ
biomedich-399	148	13	of	of	ADP
biomedich-399	148	14	diffusible	diffusible	ADJ
biomedich-399	148	15	reactive	reactive	ADJ
biomedich-399	148	16	oxygen	oxygen	NOUN
biomedich-399	148	17	species	species	NOUN
biomedich-399	148	18	generation	generation	NOUN
biomedich-399	148	19	.	.	PUNCT
biomedich-399	149	1	redox	redox	ADJ
biomedich-399	149	2	biology	biology	NOUN
biomedich-399	149	3	,	,	PUNCT
biomedich-399	149	4	2	2	NUM
biomedich-399	149	5	,	,	PUNCT
biomedich-399	149	6	865–872	865–872	NUM
biomedich-399	149	7	.	.	PUNCT
biomedich-399	150	1	https://doi.org/10.1016/j.redox.2014.06.007	https://doi.org/10.1016/j.redox.2014.06.007	VERB
biomedich-399	150	2	veber	veber	PROPN
biomedich-399	150	3	,	,	PUNCT
biomedich-399	150	4	d.	d.	PROPN
biomedich-399	150	5	f.	f.	PROPN
biomedich-399	150	6	,	,	PUNCT
biomedich-399	150	7	johnson	johnson	PROPN
biomedich-399	150	8	,	,	PUNCT
biomedich-399	150	9	s.	s.	PROPN
biomedich-399	150	10	r.	r.	PROPN
biomedich-399	150	11	,	,	PUNCT
biomedich-399	150	12	cheng	cheng	PROPN
biomedich-399	150	13	,	,	PUNCT
biomedich-399	150	14	h.-y	h.-y	NOUN
biomedich-399	150	15	.	.	PUNCT
biomedich-399	150	16	,	,	PUNCT
biomedich-399	150	17	smith	smith	PROPN
biomedich-399	150	18	,	,	PUNCT
biomedich-399	150	19	b.	b.	PROPN
biomedich-399	150	20	r.	r.	PROPN
biomedich-399	150	21	,	,	PUNCT
biomedich-399	150	22	ward	ward	PROPN
biomedich-399	150	23	,	,	PUNCT
biomedich-399	150	24	k.	k.	PROPN
biomedich-399	150	25	w.	w.	PROPN
biomedich-399	150	26	,	,	PUNCT
biomedich-399	150	27	&	&	CCONJ
biomedich-399	150	28	kopple	kopple	PROPN
biomedich-399	150	29	,	,	PUNCT
biomedich-399	150	30	k.	k.	PROPN
biomedich-399	150	31	d.	d.	PROPN
biomedich-399	150	32	(	(	PUNCT
biomedich-399	150	33	2002	2002	NUM
biomedich-399	150	34	)	)	PUNCT
biomedich-399	150	35	.	.	PUNCT
biomedich-399	151	1	molecular	molecular	ADJ
biomedich-399	151	2	properties	property	NOUN
biomedich-399	151	3	that	that	PRON
biomedich-399	151	4	influence	influence	VERB
biomedich-399	151	5	the	the	DET
biomedich-399	151	6	oral	oral	ADJ
biomedich-399	151	7	bioavailability	bioavailability	NOUN
biomedich-399	151	8	of	of	ADP
biomedich-399	151	9	drug	drug	NOUN
biomedich-399	151	10	candidates	candidate	NOUN
biomedich-399	151	11	.	.	PUNCT
biomedich-399	152	1	journal	journal	NOUN
biomedich-399	152	2	of	of	ADP
biomedich-399	152	3	medicinal	medicinal	ADJ
biomedich-399	152	4	chemistry	chemistry	NOUN
biomedich-399	152	5	,	,	PUNCT
biomedich-399	152	6	45(12	45(12	NUM
biomedich-399	152	7	)	)	PUNCT
biomedich-399	152	8	,	,	PUNCT
biomedich-399	152	9	2615–2623	2615–2623	NUM
biomedich-399	152	10	.	.	PUNCT
biomedich-399	153	1	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	PROPN
biomedich-399	153	2	wang	wang	PROPN
biomedich-399	153	3	,	,	PUNCT
biomedich-399	153	4	j.	j.	PROPN
biomedich-399	153	5	c.	c.	PROPN
biomedich-399	153	6	(	(	PUNCT
biomedich-399	153	7	2009	2009	NUM
biomedich-399	153	8	)	)	PUNCT
biomedich-399	153	9	.	.	PUNCT
biomedich-399	154	1	untangling	untangle	VERB
biomedich-399	154	2	the	the	DET
biomedich-399	154	3	double	double	ADJ
biomedich-399	154	4	helix	helix	NOUN
biomedich-399	154	5	dna	dna	NOUN
biomedich-399	154	6	entanglement	entanglement	NOUN
biomedich-399	154	7	and	and	CCONJ
biomedich-399	154	8	the	the	DET
biomedich-399	154	9	action	action	NOUN
biomedich-399	154	10	of	of	ADP
biomedich-399	154	11	the	the	DET
biomedich-399	154	12	dna	dna	PROPN
biomedich-399	154	13	topoisomerases	topoisomerase	NOUN
biomedich-399	154	14	.	.	PUNCT
biomedich-399	155	1	cold	cold	ADJ
biomedich-399	155	2	spring	spring	NOUN
biomedich-399	155	3	harbor	harbor	PROPN
biomedich-399	155	4	laboratory	laboratory	PROPN
biomedich-399	155	5	press	press	PROPN
biomedich-399	155	6	,	,	PUNCT
biomedich-399	155	7	cold	cold	ADJ
biomedich-399	155	8	spring	spring	NOUN
biomedich-399	155	9	harbor	harbor	NOUN
biomedich-399	155	10	,	,	PUNCT
biomedich-399	155	11	ny	ny	PROPN
biomedich-399	155	12	.	.	PROPN
biomedich-399	155	13	weseler	weseler	PROPN
biomedich-399	155	14	,	,	PUNCT
biomedich-399	155	15	a.	a.	PROPN
biomedich-399	155	16	r.	r.	PROPN
biomedich-399	155	17	,	,	PUNCT
biomedich-399	155	18	&	&	CCONJ
biomedich-399	155	19	bast	bast	NOUN
biomedich-399	155	20	,	,	PUNCT
biomedich-399	155	21	a.	a.	NOUN
biomedich-399	155	22	(	(	PUNCT
biomedich-399	155	23	2017	2017	NUM
biomedich-399	155	24	)	)	PUNCT
biomedich-399	155	25	.	.	PUNCT
biomedich-399	156	1	masquelier	masquelier	PROPN
biomedich-399	156	2	’s	’s	PART
biomedich-399	156	3	grape	grape	NOUN
biomedich-399	156	4	seed	seed	NOUN
biomedich-399	156	5	extract	extract	NOUN
biomedich-399	156	6	:	:	PUNCT
biomedich-399	156	7	from	from	ADP
biomedich-399	156	8	basic	basic	ADJ
biomedich-399	156	9	flavonoid	flavonoid	PROPN
biomedich-399	156	10	research	research	NOUN
biomedich-399	156	11	to	to	ADP
biomedich-399	156	12	a	a	DET
biomedich-399	156	13	well	well	ADV
biomedich-399	156	14	-	-	PUNCT
biomedich-399	156	15	characterized	characterize	VERB
biomedich-399	156	16	food	food	NOUN
biomedich-399	156	17	supplement	supplement	NOUN
biomedich-399	156	18	with	with	ADP
biomedich-399	156	19	health	health	NOUN
biomedich-399	156	20	benefits	benefit	NOUN
biomedich-399	156	21	.	.	PUNCT
biomedich-399	157	1	nutrition	nutrition	NOUN
biomedich-399	157	2	journal	journal	PROPN
biomedich-399	157	3	,	,	PUNCT
biomedich-399	157	4	16(1	16(1	NUM
biomedich-399	157	5	)	)	PUNCT
biomedich-399	157	6	,	,	PUNCT
biomedich-399	157	7	5	5	X
biomedich-399	157	8	.	.	PUNCT
biomedich-399	157	9	https://doi.org/10.1186/s12937-016-0218-1	https://doi.org/10.1186/s12937-016-0218-1	PROPN
biomedich-399	157	10	yamakoshi	yamakoshi	PROPN
biomedich-399	157	11	,	,	PUNCT
biomedich-399	157	12	j.	j.	PROPN
biomedich-399	157	13	,	,	PUNCT
biomedich-399	157	14	saito	saito	PROPN
biomedich-399	157	15	,	,	PUNCT
biomedich-399	157	16	m.	m.	NOUN
biomedich-399	157	17	,	,	PUNCT
biomedich-399	157	18	kataoka	kataoka	PROPN
biomedich-399	157	19	,	,	PUNCT
biomedich-399	157	20	s.	s.	PROPN
biomedich-399	157	21	,	,	PUNCT
biomedich-399	157	22	&	&	CCONJ
biomedich-399	157	23	kikuchi	kikuchi	PROPN
biomedich-399	157	24	,	,	PUNCT
biomedich-399	157	25	m.	m.	NOUN
biomedich-399	157	26	(	(	PUNCT
biomedich-399	157	27	2002	2002	NUM
biomedich-399	157	28	)	)	PUNCT
biomedich-399	157	29	.	.	PUNCT
biomedich-399	158	1	safety	safety	NOUN
biomedich-399	158	2	evaluation	evaluation	NOUN
biomedich-399	158	3	of	of	ADP
biomedich-399	158	4	proanthocyanidin	proanthocyanidin	ADJ
biomedich-399	158	5	-	-	PUNCT
biomedich-399	158	6	rich	rich	ADJ
biomedich-399	158	7	extract	extract	NOUN
biomedich-399	158	8	from	from	ADP
biomedich-399	158	9	grape	grape	NOUN
biomedich-399	158	10	seeds	seed	NOUN
biomedich-399	158	11	.	.	PUNCT
biomedich-399	159	1	food	food	NOUN
biomedich-399	159	2	and	and	CCONJ
biomedich-399	159	3	chemical	chemical	NOUN
biomedich-399	159	4	toxicology	toxicology	NOUN
biomedich-399	159	5	,	,	PUNCT
biomedich-399	159	6	40(5	40(5	NOUN
biomedich-399	159	7	)	)	PUNCT
biomedich-399	159	8	,	,	PUNCT
biomedich-399	159	9	599–607	599–607	NUM
biomedich-399	159	10	.	.	PUNCT
biomedich-399	160	1	https://doi.org/10.1016/s0278-6915(02)00006-6	https://doi.org/10.1016/s0278-6915(02)00006-6	NOUN