id	sid	tid	token	lemma	pos
biomedich-495	1	1	biology	biology	NOUN
biomedich-495	1	2	,	,	PUNCT
biomedich-495	1	3	medicine	medicine	NOUN
biomedich-495	1	4	,	,	PUNCT
biomedich-495	1	5	&	&	CCONJ
biomedich-495	1	6	natural	natural	ADJ
biomedich-495	1	7	product	product	NOUN
biomedich-495	1	8	chemistry	chemistry	NOUN
biomedich-495	1	9	issn	issn	VERB
biomedich-495	1	10	2089	2089	NUM
biomedich-495	1	11	-	-	SYM
biomedich-495	1	12	6514	6514	NUM
biomedich-495	1	13	(	(	PUNCT
biomedich-495	1	14	paper	paper	NOUN
biomedich-495	1	15	)	)	PUNCT
biomedich-495	1	16	volume	volume	NOUN
biomedich-495	1	17	13	13	NUM
biomedich-495	1	18	,	,	PUNCT
biomedich-495	1	19	number	number	NOUN
biomedich-495	1	20	1	1	NUM
biomedich-495	1	21	,	,	PUNCT
biomedich-495	1	22	april	april	PROPN
biomedich-495	1	23	2024	2024	NUM
biomedich-495	1	24	|	|	ADV
biomedich-495	1	25	pages	page	NOUN
biomedich-495	1	26	:	:	PUNCT
biomedich-495	1	27	205	205	NUM
biomedich-495	1	28	-	-	SYM
biomedich-495	1	29	214	214	NUM
biomedich-495	1	30	|	|	ADV
biomedich-495	1	31	doi	doi	NOUN
biomedich-495	1	32	:	:	PUNCT
biomedich-495	1	33	10.14421	10.14421	NUM
biomedich-495	1	34	/	/	SYM
biomedich-495	1	35	biomedich.2024.131.205	biomedich.2024.131.205	NOUN
biomedich-495	1	36	-	-	ADJ
biomedich-495	1	37	214	214	NUM
biomedich-495	1	38	issn	issn	PROPN
biomedich-495	1	39	2540	2540	NUM
biomedich-495	1	40	-	-	SYM
biomedich-495	1	41	9328	9328	NUM
biomedich-495	1	42	(	(	PUNCT
biomedich-495	1	43	online	online	ADJ
biomedich-495	1	44	)	)	PUNCT
biomedich-495	1	45	antimicrobial	antimicrobial	ADJ
biomedich-495	1	46	potential	potential	NOUN
biomedich-495	1	47	of	of	ADP
biomedich-495	1	48	selected	select	VERB
biomedich-495	1	49	phytochemicals	phytochemical	NOUN
biomedich-495	1	50	from	from	ADP
biomedich-495	1	51	hygrophila	hygrophila	PROPN
biomedich-495	1	52	schulli	schulli	PROPN
biomedich-495	1	53	;	;	PUNCT
biomedich-495	1	54	computational	computational	ADJ
biomedich-495	1	55	insights	insight	NOUN
biomedich-495	1	56	pasindu	pasindu	NOUN
biomedich-495	1	57	dilshan	dilshan	PROPN
biomedich-495	1	58	perera	perera	PROPN
biomedich-495	1	59	*	*	PROPN
biomedich-495	1	60	,	,	PUNCT
biomedich-495	1	61	haritha	haritha	PROPN
biomedich-495	1	62	lawan	lawan	PROPN
biomedich-495	1	63	department	department	PROPN
biomedich-495	1	64	of	of	ADP
biomedich-495	1	65	chemistry	chemistry	NOUN
biomedich-495	1	66	,	,	PUNCT
biomedich-495	1	67	university	university	NOUN
biomedich-495	1	68	of	of	ADP
biomedich-495	1	69	kelaniya	kelaniya	PROPN
biomedich-495	1	70	,	,	PUNCT
biomedich-495	1	71	sri	sri	PROPN
biomedich-495	1	72	lanka	lanka	PROPN
biomedich-495	1	73	.	.	PUNCT
biomedich-495	2	1	corresponding	correspond	VERB
biomedich-495	2	2	author	author	NOUN
biomedich-495	2	3	*	*	PROPN
biomedich-495	2	4	pasindudilshan544@gmail.com	pasindudilshan544@gmail.com	X
biomedich-495	2	5	manuscript	manuscript	NOUN
biomedich-495	2	6	received	receive	VERB
biomedich-495	2	7	:	:	PUNCT
biomedich-495	2	8	28	28	NUM
biomedich-495	2	9	february	february	PROPN
biomedich-495	2	10	,	,	PUNCT
biomedich-495	2	11	2024	2024	NUM
biomedich-495	2	12	.	.	PUNCT
biomedich-495	3	1	revision	revision	NOUN
biomedich-495	3	2	accepted	accept	VERB
biomedich-495	3	3	:	:	PUNCT
biomedich-495	3	4	20	20	NUM
biomedich-495	3	5	may	may	NOUN
biomedich-495	3	6	,	,	PUNCT
biomedich-495	3	7	2024	2024	NUM
biomedich-495	3	8	.	.	PUNCT
biomedich-495	4	1	published	publish	VERB
biomedich-495	4	2	:	:	PUNCT
biomedich-495	4	3	12	12	NUM
biomedich-495	4	4	june	june	PROPN
biomedich-495	4	5	,	,	PUNCT
biomedich-495	4	6	2024	2024	NUM
biomedich-495	4	7	.	.	PUNCT
biomedich-495	5	1	abstract	abstract	VERB
biomedich-495	5	2	the	the	DET
biomedich-495	5	3	escalating	escalate	VERB
biomedich-495	5	4	global	global	ADJ
biomedich-495	5	5	concern	concern	NOUN
biomedich-495	5	6	over	over	ADP
biomedich-495	5	7	antibiotic	antibiotic	ADJ
biomedich-495	5	8	resistance	resistance	NOUN
biomedich-495	5	9	has	have	AUX
biomedich-495	5	10	led	lead	VERB
biomedich-495	5	11	to	to	ADP
biomedich-495	5	12	an	an	DET
biomedich-495	5	13	intensified	intensify	VERB
biomedich-495	5	14	exploration	exploration	NOUN
biomedich-495	5	15	of	of	ADP
biomedich-495	5	16	alternative	alternative	ADJ
biomedich-495	5	17	therapeutic	therapeutic	ADJ
biomedich-495	5	18	strategies	strategy	NOUN
biomedich-495	5	19	,	,	PUNCT
biomedich-495	5	20	including	include	VERB
biomedich-495	5	21	the	the	DET
biomedich-495	5	22	utilization	utilization	NOUN
biomedich-495	5	23	of	of	ADP
biomedich-495	5	24	plant	plant	NOUN
biomedich-495	5	25	-	-	PUNCT
biomedich-495	5	26	derived	derive	VERB
biomedich-495	5	27	secondary	secondary	ADJ
biomedich-495	5	28	metabolites	metabolite	NOUN
biomedich-495	5	29	.	.	PUNCT
biomedich-495	6	1	in	in	ADP
biomedich-495	6	2	this	this	DET
biomedich-495	6	3	in	in	ADP
biomedich-495	6	4	-	-	PUNCT
biomedich-495	6	5	silico	silico	NOUN
biomedich-495	6	6	study	study	NOUN
biomedich-495	6	7	,	,	PUNCT
biomedich-495	6	8	we	we	PRON
biomedich-495	6	9	investigated	investigate	VERB
biomedich-495	6	10	the	the	DET
biomedich-495	6	11	structural	structural	ADJ
biomedich-495	6	12	inhibition	inhibition	NOUN
biomedich-495	6	13	of	of	ADP
biomedich-495	6	14	bacterial	bacterial	ADJ
biomedich-495	6	15	dna	dna	NOUN
biomedich-495	6	16	topoisomerase	topoisomerase	NOUN
biomedich-495	6	17	iv	iv	X
biomedich-495	6	18	complex	complex	ADJ
biomedich-495	6	19	by	by	ADP
biomedich-495	6	20	major	major	ADJ
biomedich-495	6	21	secondary	secondary	ADJ
biomedich-495	6	22	metabolites	metabolite	NOUN
biomedich-495	6	23	extracted	extract	VERB
biomedich-495	6	24	from	from	ADP
biomedich-495	6	25	the	the	DET
biomedich-495	6	26	medicinal	medicinal	ADJ
biomedich-495	6	27	plant	plant	NOUN
biomedich-495	6	28	hygrophila	hygrophila	PROPN
biomedich-495	6	29	schulli	schulli	PROPN
biomedich-495	6	30	.	.	PUNCT
biomedich-495	7	1	the	the	DET
biomedich-495	7	2	plant	plant	NOUN
biomedich-495	7	3	is	be	AUX
biomedich-495	7	4	renowned	renowne	VERB
biomedich-495	7	5	for	for	ADP
biomedich-495	7	6	its	its	PRON
biomedich-495	7	7	rich	rich	ADJ
biomedich-495	7	8	phytochemical	phytochemical	ADJ
biomedich-495	7	9	composition	composition	NOUN
biomedich-495	7	10	,	,	PUNCT
biomedich-495	7	11	possessing	possess	VERB
biomedich-495	7	12	bioactive	bioactive	NOUN
biomedich-495	7	13	compounds	compound	NOUN
biomedich-495	7	14	with	with	ADP
biomedich-495	7	15	diverse	diverse	ADJ
biomedich-495	7	16	pharmacological	pharmacological	ADJ
biomedich-495	7	17	properties	property	NOUN
biomedich-495	7	18	.	.	PUNCT
biomedich-495	8	1	using	use	VERB
biomedich-495	8	2	computational	computational	ADJ
biomedich-495	8	3	approaches	approach	NOUN
biomedich-495	8	4	,	,	PUNCT
biomedich-495	8	5	we	we	PRON
biomedich-495	8	6	conducted	conduct	VERB
biomedich-495	8	7	molecular	molecular	ADJ
biomedich-495	8	8	docking	docking	NOUN
biomedich-495	8	9	simulations	simulation	NOUN
biomedich-495	8	10	to	to	PART
biomedich-495	8	11	explore	explore	VERB
biomedich-495	8	12	the	the	DET
biomedich-495	8	13	binding	bind	VERB
biomedich-495	8	14	affinities	affinity	NOUN
biomedich-495	8	15	and	and	CCONJ
biomedich-495	8	16	interactions	interaction	NOUN
biomedich-495	8	17	between	between	ADP
biomedich-495	8	18	the	the	DET
biomedich-495	8	19	identified	identify	VERB
biomedich-495	8	20	secondary	secondary	ADJ
biomedich-495	8	21	metabolites	metabolite	NOUN
biomedich-495	8	22	from	from	ADP
biomedich-495	8	23	hygrophila	hygrophila	PROPN
biomedich-495	8	24	schulli	schulli	PROPN
biomedich-495	8	25	and	and	CCONJ
biomedich-495	8	26	the	the	DET
biomedich-495	8	27	target	target	NOUN
biomedich-495	8	28	bacterial	bacterial	ADJ
biomedich-495	8	29	dna	dna	NOUN
biomedich-495	8	30	topoisomerase	topoisomerase	NOUN
biomedich-495	8	31	iv	iv	NUM
biomedich-495	8	32	complex	complex	ADJ
biomedich-495	8	33	.	.	PUNCT
biomedich-495	9	1	our	our	PRON
biomedich-495	9	2	results	result	NOUN
biomedich-495	9	3	unveil	unveil	VERB
biomedich-495	9	4	promising	promising	ADJ
biomedich-495	9	5	interactions	interaction	NOUN
biomedich-495	9	6	,	,	PUNCT
biomedich-495	9	7	suggesting	suggest	VERB
biomedich-495	9	8	a	a	DET
biomedich-495	9	9	potential	potential	ADJ
biomedich-495	9	10	inhibitory	inhibitory	ADJ
biomedich-495	9	11	effect	effect	NOUN
biomedich-495	9	12	on	on	ADP
biomedich-495	9	13	the	the	DET
biomedich-495	9	14	targeted	target	VERB
biomedich-495	9	15	protein	protein	NOUN
biomedich-495	9	16	.	.	PUNCT
biomedich-495	10	1	furthermore	furthermore	ADV
biomedich-495	10	2	,	,	PUNCT
biomedich-495	10	3	molecular	molecular	ADJ
biomedich-495	10	4	dynamics	dynamic	NOUN
biomedich-495	10	5	simulations	simulation	NOUN
biomedich-495	10	6	were	be	AUX
biomedich-495	10	7	employed	employ	VERB
biomedich-495	10	8	to	to	PART
biomedich-495	10	9	examine	examine	VERB
biomedich-495	10	10	the	the	DET
biomedich-495	10	11	dynamic	dynamic	ADJ
biomedich-495	10	12	behavior	behavior	NOUN
biomedich-495	10	13	of	of	ADP
biomedich-495	10	14	the	the	DET
biomedich-495	10	15	ligand	ligand	ADJ
biomedich-495	10	16	-	-	PUNCT
biomedich-495	10	17	protein	protein	NOUN
biomedich-495	10	18	complexes	complex	NOUN
biomedich-495	10	19	,	,	PUNCT
biomedich-495	10	20	providing	provide	VERB
biomedich-495	10	21	insights	insight	NOUN
biomedich-495	10	22	into	into	ADP
biomedich-495	10	23	the	the	DET
biomedich-495	10	24	stability	stability	NOUN
biomedich-495	10	25	and	and	CCONJ
biomedich-495	10	26	conformational	conformational	ADJ
biomedich-495	10	27	changes	change	NOUN
biomedich-495	10	28	over	over	ADP
biomedich-495	10	29	time	time	NOUN
biomedich-495	10	30	.	.	PUNCT
biomedich-495	11	1	this	this	DET
biomedich-495	11	2	in	in	ADP
biomedich-495	11	3	-	-	PUNCT
biomedich-495	11	4	silico	silico	NOUN
biomedich-495	11	5	exploration	exploration	NOUN
biomedich-495	11	6	contributes	contribute	VERB
biomedich-495	11	7	valuable	valuable	ADJ
biomedich-495	11	8	information	information	NOUN
biomedich-495	11	9	to	to	ADP
biomedich-495	11	10	the	the	DET
biomedich-495	11	11	understanding	understanding	NOUN
biomedich-495	11	12	of	of	ADP
biomedich-495	11	13	the	the	DET
biomedich-495	11	14	molecular	molecular	ADJ
biomedich-495	11	15	interactions	interaction	NOUN
biomedich-495	11	16	between	between	ADP
biomedich-495	11	17	plant	plant	NOUN
biomedich-495	11	18	-	-	PUNCT
biomedich-495	11	19	derived	derive	VERB
biomedich-495	11	20	secondary	secondary	ADJ
biomedich-495	11	21	metabolites	metabolite	NOUN
biomedich-495	11	22	and	and	CCONJ
biomedich-495	11	23	bacterial	bacterial	ADJ
biomedich-495	11	24	dna	dna	NOUN
biomedich-495	11	25	topoisomerase	topoisomerase	NOUN
biomedich-495	11	26	iv	iv	NUM
biomedich-495	11	27	,	,	PUNCT
biomedich-495	11	28	laying	lay	VERB
biomedich-495	11	29	the	the	DET
biomedich-495	11	30	groundwork	groundwork	NOUN
biomedich-495	11	31	for	for	ADP
biomedich-495	11	32	future	future	ADJ
biomedich-495	11	33	experimental	experimental	ADJ
biomedich-495	11	34	validations	validation	NOUN
biomedich-495	11	35	.	.	PUNCT
biomedich-495	12	1	the	the	DET
biomedich-495	12	2	findings	finding	NOUN
biomedich-495	12	3	from	from	ADP
biomedich-495	12	4	this	this	DET
biomedich-495	12	5	study	study	NOUN
biomedich-495	12	6	may	may	AUX
biomedich-495	12	7	pave	pave	VERB
biomedich-495	12	8	the	the	DET
biomedich-495	12	9	way	way	NOUN
biomedich-495	12	10	for	for	ADP
biomedich-495	12	11	the	the	DET
biomedich-495	12	12	development	development	NOUN
biomedich-495	12	13	of	of	ADP
biomedich-495	12	14	novel	novel	ADJ
biomedich-495	12	15	antimicrobial	antimicrobial	ADJ
biomedich-495	12	16	agents	agent	NOUN
biomedich-495	12	17	derived	derive	VERB
biomedich-495	12	18	from	from	ADP
biomedich-495	12	19	natural	natural	ADJ
biomedich-495	12	20	sources	source	NOUN
biomedich-495	12	21	,	,	PUNCT
biomedich-495	12	22	offering	offer	VERB
biomedich-495	12	23	a	a	DET
biomedich-495	12	24	sustainable	sustainable	ADJ
biomedich-495	12	25	and	and	CCONJ
biomedich-495	12	26	effective	effective	ADJ
biomedich-495	12	27	approach	approach	NOUN
biomedich-495	12	28	in	in	ADP
biomedich-495	12	29	the	the	DET
biomedich-495	12	30	ongoing	ongoing	ADJ
biomedich-495	12	31	battle	battle	NOUN
biomedich-495	12	32	against	against	ADP
biomedich-495	12	33	antibiotic	antibiotic	NOUN
biomedich-495	12	34	-	-	PUNCT
biomedich-495	12	35	resistant	resistant	ADJ
biomedich-495	12	36	bacterial	bacterial	ADJ
biomedich-495	12	37	infections	infection	NOUN
biomedich-495	12	38	.	.	PUNCT
biomedich-495	13	1	keywords	keyword	NOUN
biomedich-495	13	2	:	:	PUNCT
biomedich-495	13	3	dna	dna	PROPN
biomedich-495	13	4	topoisomerase	topoisomerase	PROPN
biomedich-495	13	5	;	;	PUNCT
biomedich-495	13	6	hygrophila	hygrophila	PROPN
biomedich-495	13	7	schulli	schulli	PROPN
biomedich-495	13	8	;	;	PUNCT
biomedich-495	13	9	lupeol	lupeol	NOUN
biomedich-495	13	10	;	;	PUNCT
biomedich-495	13	11	molecular	molecular	ADJ
biomedich-495	13	12	docking	docking	NOUN
biomedich-495	13	13	;	;	PUNCT
biomedich-495	13	14	physicochemical	physicochemical	ADJ
biomedich-495	13	15	.	.	PUNCT
biomedich-495	14	1	introduction	introduction	NOUN
biomedich-495	14	2	natural	natural	ADJ
biomedich-495	14	3	materials	material	NOUN
biomedich-495	14	4	,	,	PUNCT
biomedich-495	14	5	including	include	VERB
biomedich-495	14	6	parts	part	NOUN
biomedich-495	14	7	of	of	ADP
biomedich-495	14	8	plants	plant	NOUN
biomedich-495	14	9	,	,	PUNCT
biomedich-495	14	10	animals	animal	NOUN
biomedich-495	14	11	,	,	PUNCT
biomedich-495	14	12	and	and	CCONJ
biomedich-495	14	13	microbes	microbe	NOUN
biomedich-495	14	14	,	,	PUNCT
biomedich-495	14	15	have	have	AUX
biomedich-495	14	16	been	be	AUX
biomedich-495	14	17	used	use	VERB
biomedich-495	14	18	in	in	ADP
biomedich-495	14	19	medicine	medicine	NOUN
biomedich-495	14	20	to	to	PART
biomedich-495	14	21	heal	heal	VERB
biomedich-495	14	22	illnesses	illness	NOUN
biomedich-495	14	23	since	since	SCONJ
biomedich-495	14	24	ancient	ancient	ADJ
biomedich-495	14	25	times	time	NOUN
biomedich-495	14	26	.	.	PUNCT
biomedich-495	15	1	fossil	fossil	ADJ
biomedich-495	15	2	evidence	evidence	NOUN
biomedich-495	15	3	suggests	suggest	VERB
biomedich-495	15	4	that	that	SCONJ
biomedich-495	15	5	humans	human	NOUN
biomedich-495	15	6	have	have	AUX
biomedich-495	15	7	been	be	AUX
biomedich-495	15	8	using	use	VERB
biomedich-495	15	9	plants	plant	NOUN
biomedich-495	15	10	as	as	ADP
biomedich-495	15	11	medicine	medicine	NOUN
biomedich-495	15	12	for	for	ADP
biomedich-495	15	13	at	at	ADV
biomedich-495	15	14	least	least	ADV
biomedich-495	15	15	60,000	60,000	NUM
biomedich-495	15	16	years	year	NOUN
biomedich-495	15	17	(	(	PUNCT
biomedich-495	15	18	yuan	yuan	NOUN
biomedich-495	15	19	et	et	NOUN
biomedich-495	15	20	al	al	PROPN
biomedich-495	15	21	.	.	PROPN
biomedich-495	15	22	,	,	PUNCT
biomedich-495	15	23	2016	2016	NUM
biomedich-495	15	24	)	)	PUNCT
biomedich-495	15	25	.	.	PUNCT
biomedich-495	16	1	plants	plant	NOUN
biomedich-495	16	2	generate	generate	VERB
biomedich-495	16	3	phytochemicals	phytochemical	NOUN
biomedich-495	16	4	,	,	PUNCT
biomedich-495	16	5	which	which	PRON
biomedich-495	16	6	are	be	AUX
biomedich-495	16	7	constitutive	constitutive	ADJ
biomedich-495	16	8	metabolites	metabolite	NOUN
biomedich-495	16	9	essential	essential	ADJ
biomedich-495	16	10	to	to	ADP
biomedich-495	16	11	their	their	PRON
biomedich-495	16	12	survival	survival	NOUN
biomedich-495	16	13	and	and	CCONJ
biomedich-495	16	14	well	well	ADV
biomedich-495	16	15	-	-	PUNCT
biomedich-495	16	16	being	being	NOUN
biomedich-495	16	17	.	.	PUNCT
biomedich-495	17	1	these	these	DET
biomedich-495	17	2	chemical	chemical	ADJ
biomedich-495	17	3	constituents	constituent	NOUN
biomedich-495	17	4	regulate	regulate	VERB
biomedich-495	17	5	pollination	pollination	NOUN
biomedich-495	17	6	,	,	PUNCT
biomedich-495	17	7	fertilization	fertilization	NOUN
biomedich-495	17	8	,	,	PUNCT
biomedich-495	17	9	growth	growth	NOUN
biomedich-495	17	10	,	,	PUNCT
biomedich-495	17	11	and	and	CCONJ
biomedich-495	17	12	the	the	DET
biomedich-495	17	13	rhizosphere	rhizosphere	ADJ
biomedich-495	17	14	environment	environment	NOUN
biomedich-495	17	15	in	in	ADP
biomedich-495	17	16	addition	addition	NOUN
biomedich-495	17	17	to	to	ADP
biomedich-495	17	18	shielding	shield	VERB
biomedich-495	17	19	plants	plant	NOUN
biomedich-495	17	20	from	from	ADP
biomedich-495	17	21	rivals	rival	NOUN
biomedich-495	17	22	,	,	PUNCT
biomedich-495	17	23	diseases	disease	NOUN
biomedich-495	17	24	,	,	PUNCT
biomedich-495	17	25	and	and	CCONJ
biomedich-495	17	26	predators	predator	NOUN
biomedich-495	17	27	(	(	PUNCT
biomedich-495	17	28	molyneux	molyneux	PROPN
biomedich-495	17	29	et	et	PROPN
biomedich-495	17	30	al	al	PROPN
biomedich-495	17	31	.	.	PROPN
biomedich-495	17	32	,	,	PUNCT
biomedich-495	17	33	2007	2007	NUM
biomedich-495	17	34	)	)	PUNCT
biomedich-495	17	35	.	.	PUNCT
biomedich-495	18	1	these	these	DET
biomedich-495	18	2	chemical	chemical	ADJ
biomedich-495	18	3	constituents	constituent	NOUN
biomedich-495	18	4	,	,	PUNCT
biomedich-495	18	5	which	which	PRON
biomedich-495	18	6	are	be	AUX
biomedich-495	18	7	thought	think	VERB
biomedich-495	18	8	to	to	PART
biomedich-495	18	9	be	be	AUX
biomedich-495	18	10	antibiotic	antibiotic	ADJ
biomedich-495	18	11	,	,	PUNCT
biomedich-495	18	12	antifungal	antifungal	ADJ
biomedich-495	18	13	,	,	PUNCT
biomedich-495	18	14	and	and	CCONJ
biomedich-495	18	15	antiviral	antiviral	NOUN
biomedich-495	18	16	,	,	PUNCT
biomedich-495	18	17	shield	shield	VERB
biomedich-495	18	18	plants	plant	NOUN
biomedich-495	18	19	from	from	ADP
biomedich-495	18	20	infections	infection	NOUN
biomedich-495	18	21	.	.	PUNCT
biomedich-495	19	1	they	they	PRON
biomedich-495	19	2	are	be	AUX
biomedich-495	19	3	also	also	ADV
biomedich-495	19	4	essential	essential	ADJ
biomedich-495	19	5	uvabsorbing	uvabsorbe	VERB
biomedich-495	19	6	chemical	chemical	ADJ
biomedich-495	19	7	components	component	NOUN
biomedich-495	19	8	that	that	PRON
biomedich-495	19	9	shield	shield	VERB
biomedich-495	19	10	leaves	leave	NOUN
biomedich-495	19	11	from	from	ADP
biomedich-495	19	12	serious	serious	ADJ
biomedich-495	19	13	light	light	ADJ
biomedich-495	19	14	-	-	PUNCT
biomedich-495	19	15	induced	induce	VERB
biomedich-495	19	16	damage	damage	NOUN
biomedich-495	19	17	(	(	PUNCT
biomedich-495	19	18	bourgaud	bourgaud	VERB
biomedich-495	19	19	et	et	PROPN
biomedich-495	19	20	al	al	PROPN
biomedich-495	19	21	.	.	PROPN
biomedich-495	19	22	,	,	PUNCT
biomedich-495	19	23	2001	2001	NUM
biomedich-495	19	24	)	)	PUNCT
biomedich-495	19	25	.	.	PUNCT
biomedich-495	20	1	sri	sri	PROPN
biomedich-495	20	2	lanka	lanka	PROPN
biomedich-495	20	3	is	be	AUX
biomedich-495	20	4	regarded	regard	VERB
biomedich-495	20	5	as	as	ADP
biomedich-495	20	6	a	a	DET
biomedich-495	20	7	hotspot	hotspot	NOUN
biomedich-495	20	8	for	for	ADP
biomedich-495	20	9	biodiversity	biodiversity	NOUN
biomedich-495	20	10	with	with	ADP
biomedich-495	20	11	a	a	DET
biomedich-495	20	12	high	high	ADJ
biomedich-495	20	13	level	level	NOUN
biomedich-495	20	14	of	of	ADP
biomedich-495	20	15	endemism	endemism	NOUN
biomedich-495	20	16	.	.	PUNCT
biomedich-495	21	1	because	because	SCONJ
biomedich-495	21	2	of	of	ADP
biomedich-495	21	3	this	this	PRON
biomedich-495	21	4	,	,	PUNCT
biomedich-495	21	5	the	the	DET
biomedich-495	21	6	flora	flora	NOUN
biomedich-495	21	7	that	that	PRON
biomedich-495	21	8	thrive	thrive	VERB
biomedich-495	21	9	on	on	ADP
biomedich-495	21	10	this	this	DET
biomedich-495	21	11	small	small	ADJ
biomedich-495	21	12	island	island	NOUN
biomedich-495	21	13	have	have	VERB
biomedich-495	21	14	special	special	ADJ
biomedich-495	21	15	physical	physical	ADJ
biomedich-495	21	16	and	and	CCONJ
biomedich-495	21	17	ecological	ecological	ADJ
biomedich-495	21	18	characteristics	characteristic	NOUN
biomedich-495	21	19	.	.	PUNCT
biomedich-495	22	1	several	several	ADJ
biomedich-495	22	2	medical	medical	ADJ
biomedich-495	22	3	systems	system	NOUN
biomedich-495	22	4	,	,	PUNCT
biomedich-495	22	5	including	include	VERB
biomedich-495	22	6	traditional	traditional	ADJ
biomedich-495	22	7	folk	folk	NOUN
biomedich-495	22	8	medicine	medicine	NOUN
biomedich-495	22	9	,	,	PUNCT
biomedich-495	22	10	ayurveda	ayurveda	NOUN
biomedich-495	22	11	,	,	PUNCT
biomedich-495	22	12	unani	unani	NOUN
biomedich-495	22	13	,	,	PUNCT
biomedich-495	22	14	and	and	CCONJ
biomedich-495	22	15	siddha	siddha	PROPN
biomedich-495	22	16	,	,	PUNCT
biomedich-495	22	17	have	have	AUX
biomedich-495	22	18	enhanced	enhance	VERB
biomedich-495	22	19	the	the	DET
biomedich-495	22	20	use	use	NOUN
biomedich-495	22	21	of	of	ADP
biomedich-495	22	22	herbs	herb	NOUN
biomedich-495	22	23	as	as	ADP
biomedich-495	22	24	therapeutic	therapeutic	ADJ
biomedich-495	22	25	agents	agent	NOUN
biomedich-495	22	26	in	in	ADP
biomedich-495	22	27	sri	sri	PROPN
biomedich-495	22	28	lanka	lanka	PROPN
biomedich-495	22	29	(	(	PUNCT
biomedich-495	22	30	nissanka	nissanka	PROPN
biomedich-495	22	31	et	et	PROPN
biomedich-495	22	32	al	al	PROPN
biomedich-495	22	33	.	.	PROPN
biomedich-495	22	34	,	,	PUNCT
biomedich-495	22	35	2023	2023	NUM
biomedich-495	22	36	)	)	PUNCT
biomedich-495	22	37	.	.	PUNCT
biomedich-495	23	1	one	one	NUM
biomedich-495	23	2	such	such	ADJ
biomedich-495	23	3	plant	plant	NOUN
biomedich-495	23	4	,	,	PUNCT
biomedich-495	23	5	native	native	ADJ
biomedich-495	23	6	to	to	ADP
biomedich-495	23	7	sri	sri	PROPN
biomedich-495	23	8	lanka	lanka	PROPN
biomedich-495	23	9	,	,	PUNCT
biomedich-495	23	10	is	be	AUX
biomedich-495	23	11	hygrophila	hygrophila	PROPN
biomedich-495	23	12	schulli	schulli	PROPN
biomedich-495	23	13	,	,	PUNCT
biomedich-495	23	14	which	which	PRON
biomedich-495	23	15	is	be	AUX
biomedich-495	23	16	widely	widely	ADV
biomedich-495	23	17	utilized	utilize	VERB
biomedich-495	23	18	to	to	PART
biomedich-495	23	19	treat	treat	VERB
biomedich-495	23	20	a	a	DET
biomedich-495	23	21	wide	wide	ADJ
biomedich-495	23	22	range	range	NOUN
biomedich-495	23	23	of	of	ADP
biomedich-495	23	24	medical	medical	ADJ
biomedich-495	23	25	ailments	ailment	NOUN
biomedich-495	23	26	in	in	ADP
biomedich-495	23	27	both	both	CCONJ
biomedich-495	23	28	traditional	traditional	ADJ
biomedich-495	23	29	and	and	CCONJ
biomedich-495	23	30	ayurvedic	ayurvedic	ADJ
biomedich-495	23	31	systems	system	NOUN
biomedich-495	23	32	.	.	PUNCT
biomedich-495	24	1	it	it	PRON
biomedich-495	24	2	is	be	AUX
biomedich-495	24	3	referred	refer	VERB
biomedich-495	24	4	to	to	ADP
biomedich-495	24	5	as	as	ADP
biomedich-495	24	6	"	"	PUNCT
biomedich-495	24	7	neeramulliya	neeramulliya	NOUN
biomedich-495	24	8	"	"	PUNCT
biomedich-495	24	9	or	or	CCONJ
biomedich-495	24	10	"	"	PUNCT
biomedich-495	24	11	niramulli	niramulli	NOUN
biomedich-495	24	12	"	"	PUNCT
biomedich-495	24	13	in	in	ADP
biomedich-495	24	14	sri	sri	PROPN
biomedich-495	24	15	lanka	lanka	PROPN
biomedich-495	24	16	(	(	PUNCT
biomedich-495	24	17	hewawasam	hewawasam	INTJ
biomedich-495	24	18	et	et	PROPN
biomedich-495	24	19	al	al	PROPN
biomedich-495	24	20	.	.	PROPN
biomedich-495	24	21	,	,	PUNCT
biomedich-495	24	22	2003	2003	NUM
biomedich-495	24	23	)	)	PUNCT
biomedich-495	24	24	.	.	PUNCT
biomedich-495	25	1	the	the	DET
biomedich-495	25	2	entire	entire	ADJ
biomedich-495	25	3	h.	h.	PROPN
biomedich-495	25	4	schulli	schulli	PROPN
biomedich-495	25	5	plant	plant	NOUN
biomedich-495	25	6	,	,	PUNCT
biomedich-495	25	7	as	as	ADV
biomedich-495	25	8	well	well	ADV
biomedich-495	25	9	as	as	ADP
biomedich-495	25	10	its	its	PRON
biomedich-495	25	11	roots	root	NOUN
biomedich-495	25	12	,	,	PUNCT
biomedich-495	25	13	leaves	leave	NOUN
biomedich-495	25	14	,	,	PUNCT
biomedich-495	25	15	flowers	flower	NOUN
biomedich-495	25	16	,	,	PUNCT
biomedich-495	25	17	and	and	CCONJ
biomedich-495	25	18	seeds	seed	NOUN
biomedich-495	25	19	,	,	PUNCT
biomedich-495	25	20	are	be	AUX
biomedich-495	25	21	employed	employ	VERB
biomedich-495	25	22	in	in	ADP
biomedich-495	25	23	treatment	treatment	NOUN
biomedich-495	25	24	(	(	PUNCT
biomedich-495	25	25	shoma	shoma	X
biomedich-495	25	26	et	et	PROPN
biomedich-495	25	27	al	al	PROPN
biomedich-495	25	28	.	.	PROPN
biomedich-495	25	29	,	,	PUNCT
biomedich-495	25	30	2018	2018	NUM
biomedich-495	25	31	)	)	PUNCT
biomedich-495	25	32	.	.	PUNCT
biomedich-495	26	1	h.	h.	PROPN
biomedich-495	26	2	schulli	schulli	PROPN
biomedich-495	26	3	leaves	leave	VERB
biomedich-495	26	4	and	and	CCONJ
biomedich-495	26	5	young	young	ADJ
biomedich-495	26	6	stems	stem	NOUN
biomedich-495	26	7	are	be	AUX
biomedich-495	26	8	widely	widely	ADV
biomedich-495	26	9	used	use	VERB
biomedich-495	26	10	in	in	ADP
biomedich-495	26	11	ayurveda	ayurveda	NOUN
biomedich-495	26	12	medicine	medicine	NOUN
biomedich-495	26	13	to	to	PART
biomedich-495	26	14	treat	treat	VERB
biomedich-495	26	15	a	a	DET
biomedich-495	26	16	variety	variety	NOUN
biomedich-495	26	17	of	of	ADP
biomedich-495	26	18	conditions	condition	NOUN
biomedich-495	26	19	,	,	PUNCT
biomedich-495	26	20	including	include	VERB
biomedich-495	26	21	hepatic	hepatic	ADJ
biomedich-495	26	22	diseases	disease	NOUN
biomedich-495	26	23	,	,	PUNCT
biomedich-495	26	24	microbial	microbial	ADJ
biomedich-495	26	25	infections	infection	NOUN
biomedich-495	26	26	like	like	ADP
biomedich-495	26	27	gonorrhea	gonorrhea	NOUN
biomedich-495	26	28	and	and	CCONJ
biomedich-495	26	29	urinary	urinary	ADJ
biomedich-495	26	30	tract	tract	NOUN
biomedich-495	26	31	infections	infection	NOUN
biomedich-495	26	32	,	,	PUNCT
biomedich-495	26	33	cough	cough	NOUN
biomedich-495	26	34	,	,	PUNCT
biomedich-495	26	35	joint	joint	ADJ
biomedich-495	26	36	pains	pain	NOUN
biomedich-495	26	37	,	,	PUNCT
biomedich-495	26	38	bacterial	bacterial	ADJ
biomedich-495	26	39	infections	infection	NOUN
biomedich-495	26	40	,	,	PUNCT
biomedich-495	26	41	rheumatism	rheumatism	NOUN
biomedich-495	26	42	,	,	PUNCT
biomedich-495	26	43	and	and	CCONJ
biomedich-495	26	44	dysentery	dysentery	NOUN
biomedich-495	26	45	(	(	PUNCT
biomedich-495	26	46	sethiya	sethiya	ADV
biomedich-495	26	47	et	et	PROPN
biomedich-495	26	48	al	al	PROPN
biomedich-495	26	49	.	.	PROPN
biomedich-495	26	50	,	,	PUNCT
biomedich-495	26	51	2018	2018	NUM
biomedich-495	26	52	)	)	PUNCT
biomedich-495	26	53	.	.	PUNCT
biomedich-495	27	1	previous	previous	ADJ
biomedich-495	27	2	research	research	NOUN
biomedich-495	27	3	in	in	ADP
biomedich-495	27	4	a	a	DET
biomedich-495	27	5	rodent	rodent	ADJ
biomedich-495	27	6	model	model	NOUN
biomedich-495	27	7	demonstrates	demonstrate	VERB
biomedich-495	27	8	the	the	DET
biomedich-495	27	9	strong	strong	ADJ
biomedich-495	27	10	anti	anti	ADJ
biomedich-495	27	11	-	-	ADJ
biomedich-495	27	12	nociceptive	nociceptive	ADJ
biomedich-495	27	13	and	and	CCONJ
biomedich-495	27	14	anti	anti	ADJ
biomedich-495	27	15	-	-	ADJ
biomedich-495	27	16	inflammatory	inflammatory	ADJ
biomedich-495	27	17	properties	property	NOUN
biomedich-495	27	18	of	of	ADP
biomedich-495	27	19	h.	h.	PROPN
biomedich-495	27	20	schulli	schulli	PROPN
biomedich-495	27	21	seed	seed	NOUN
biomedich-495	27	22	extract	extract	NOUN
biomedich-495	27	23	.	.	PUNCT
biomedich-495	28	1	additionally	additionally	ADV
biomedich-495	28	2	,	,	PUNCT
biomedich-495	28	3	h.	h.	PROPN
biomedich-495	28	4	schulli	schulli	PROPN
biomedich-495	28	5	leaf	leaf	PROPN
biomedich-495	28	6	and	and	CCONJ
biomedich-495	28	7	root	root	NOUN
biomedich-495	28	8	extracts	extract	NOUN
biomedich-495	28	9	showed	show	VERB
biomedich-495	28	10	antibacterial	antibacterial	ADJ
biomedich-495	28	11	activity	activity	NOUN
biomedich-495	28	12	against	against	ADP
biomedich-495	28	13	a	a	DET
biomedich-495	28	14	range	range	NOUN
biomedich-495	28	15	of	of	ADP
biomedich-495	28	16	bacterial	bacterial	ADJ
biomedich-495	28	17	strains	strain	NOUN
biomedich-495	28	18	(	(	PUNCT
biomedich-495	28	19	kannur	kannur	NOUN
biomedich-495	28	20	et	et	PROPN
biomedich-495	28	21	al	al	PROPN
biomedich-495	28	22	.	.	PROPN
biomedich-495	28	23	,	,	PUNCT
biomedich-495	28	24	2012	2012	NUM
biomedich-495	28	25	)	)	PUNCT
biomedich-495	28	26	,	,	PUNCT
biomedich-495	28	27	and	and	CCONJ
biomedich-495	28	28	an	an	DET
biomedich-495	28	29	ethanolic	ethanolic	ADJ
biomedich-495	28	30	extract	extract	NOUN
biomedich-495	28	31	of	of	ADP
biomedich-495	28	32	the	the	DET
biomedich-495	28	33	seed	seed	NOUN
biomedich-495	28	34	was	be	AUX
biomedich-495	28	35	reported	report	VERB
biomedich-495	28	36	to	to	PART
biomedich-495	28	37	exhibit	exhibit	VERB
biomedich-495	28	38	antioxidant	antioxidant	ADJ
biomedich-495	28	39	qualities	quality	NOUN
biomedich-495	28	40	against	against	ADP
biomedich-495	28	41	a	a	DET
biomedich-495	28	42	variety	variety	NOUN
biomedich-495	28	43	of	of	ADP
biomedich-495	28	44	free	free	ADJ
biomedich-495	28	45	radicals	radical	NOUN
biomedich-495	28	46	(	(	PUNCT
biomedich-495	28	47	chandran	chandran	NOUN
biomedich-495	28	48	et	et	PROPN
biomedich-495	28	49	al	al	PROPN
biomedich-495	28	50	.	.	PROPN
biomedich-495	28	51	,	,	PUNCT
biomedich-495	28	52	2013	2013	NUM
biomedich-495	28	53	)	)	PUNCT
biomedich-495	28	54	.	.	PUNCT
biomedich-495	29	1	h.	h.	PROPN
biomedich-495	29	2	sp	sp	PROPN
biomedich-495	29	3	.	.	PROPN
biomedich-495	29	4	leaves	leave	NOUN
biomedich-495	29	5	and	and	CCONJ
biomedich-495	29	6	young	young	ADJ
biomedich-495	29	7	stems	stem	NOUN
biomedich-495	29	8	are	be	AUX
biomedich-495	29	9	widely	widely	ADV
biomedich-495	29	10	used	use	VERB
biomedich-495	29	11	in	in	ADP
biomedich-495	29	12	ayurveda	ayurveda	NOUN
biomedich-495	29	13	medicine	medicine	NOUN
biomedich-495	29	14	to	to	PART
biomedich-495	29	15	treat	treat	VERB
biomedich-495	29	16	a	a	DET
biomedich-495	29	17	variety	variety	NOUN
biomedich-495	29	18	of	of	ADP
biomedich-495	29	19	conditions	condition	NOUN
biomedich-495	29	20	,	,	PUNCT
biomedich-495	29	21	including	include	VERB
biomedich-495	29	22	hepatic	hepatic	ADJ
biomedich-495	29	23	diseases	disease	NOUN
biomedich-495	29	24	,	,	PUNCT
biomedich-495	29	25	microbial	microbial	ADJ
biomedich-495	29	26	infections	infection	NOUN
biomedich-495	29	27	like	like	ADP
biomedich-495	29	28	gonorrhea	gonorrhea	NOUN
biomedich-495	29	29	and	and	CCONJ
biomedich-495	29	30	urinary	urinary	ADJ
biomedich-495	29	31	tract	tract	NOUN
biomedich-495	29	32	infections	infection	NOUN
biomedich-495	29	33	,	,	PUNCT
biomedich-495	29	34	cough	cough	NOUN
biomedich-495	29	35	,	,	PUNCT
biomedich-495	29	36	joint	joint	ADJ
biomedich-495	29	37	pains	pain	NOUN
biomedich-495	29	38	,	,	PUNCT
biomedich-495	29	39	bacterial	bacterial	ADJ
biomedich-495	29	40	infections	infection	NOUN
biomedich-495	29	41	,	,	PUNCT
biomedich-495	29	42	rheumatism	rheumatism	NOUN
biomedich-495	29	43	,	,	PUNCT
biomedich-495	29	44	and	and	CCONJ
biomedich-495	29	45	dysentery	dysentery	NOUN
biomedich-495	29	46	(	(	PUNCT
biomedich-495	29	47	sethiya	sethiya	ADV
biomedich-495	29	48	et	et	PROPN
biomedich-495	29	49	al	al	PROPN
biomedich-495	29	50	.	.	PROPN
biomedich-495	29	51	,	,	PUNCT
biomedich-495	29	52	2018	2018	NUM
biomedich-495	29	53	)	)	PUNCT
biomedich-495	29	54	.	.	PUNCT
biomedich-495	30	1	https://doi.org/10.14421/biomedich.2024.131.205-214	https://doi.org/10.14421/biomedich.2024.131.205-214	PUNCT
biomedich-495	30	2	206	206	NUM
biomedich-495	30	3	biology	biology	NOUN
biomedich-495	30	4	,	,	PUNCT
biomedich-495	30	5	medicine	medicine	NOUN
biomedich-495	30	6	,	,	PUNCT
biomedich-495	30	7	&	&	CCONJ
biomedich-495	30	8	natural	natural	ADJ
biomedich-495	30	9	product	product	NOUN
biomedich-495	30	10	chemistry	chemistry	NOUN
biomedich-495	30	11	13	13	NUM
biomedich-495	30	12	(	(	PUNCT
biomedich-495	30	13	1	1	NUM
biomedich-495	30	14	)	)	PUNCT
biomedich-495	30	15	,	,	PUNCT
biomedich-495	30	16	2024	2024	NUM
biomedich-495	30	17	:	:	PUNCT
biomedich-495	30	18	205	205	NUM
biomedich-495	30	19	-	-	SYM
biomedich-495	30	20	214	214	NUM
biomedich-495	30	21	dna	dna	PROPN
biomedich-495	30	22	topoisomerases	topoisomerase	NOUN
biomedich-495	30	23	,	,	PUNCT
biomedich-495	30	24	also	also	ADV
biomedich-495	30	25	known	know	VERB
biomedich-495	30	26	as	as	ADP
biomedich-495	30	27	topoisomerases	topoisomerase	NOUN
biomedich-495	30	28	,	,	PUNCT
biomedich-495	30	29	are	be	AUX
biomedich-495	30	30	enzymes	enzyme	NOUN
biomedich-495	30	31	that	that	PRON
biomedich-495	30	32	mediate	mediate	VERB
biomedich-495	30	33	modifications	modification	NOUN
biomedich-495	30	34	to	to	ADP
biomedich-495	30	35	the	the	DET
biomedich-495	30	36	topological	topological	ADJ
biomedich-495	30	37	state	state	NOUN
biomedich-495	30	38	of	of	ADP
biomedich-495	30	39	dna	dna	PROPN
biomedich-495	30	40	,	,	PUNCT
biomedich-495	30	41	transforming	transform	VERB
biomedich-495	30	42	dna	dna	NOUN
biomedich-495	30	43	into	into	ADP
biomedich-495	30	44	knotted	knotted	ADJ
biomedich-495	30	45	and	and	CCONJ
biomedich-495	30	46	unknotted	unknotted	ADJ
biomedich-495	30	47	forms	form	NOUN
biomedich-495	30	48	,	,	PUNCT
biomedich-495	30	49	relaxed	relaxed	ADJ
biomedich-495	30	50	and	and	CCONJ
biomedich-495	30	51	supercoiled	supercoile	VERB
biomedich-495	30	52	forms	form	NOUN
biomedich-495	30	53	,	,	PUNCT
biomedich-495	30	54	and	and	CCONJ
biomedich-495	30	55	linked	link	VERB
biomedich-495	30	56	and	and	CCONJ
biomedich-495	30	57	unlinked	unlinked	ADJ
biomedich-495	30	58	species	specie	NOUN
biomedich-495	30	59	(	(	PUNCT
biomedich-495	30	60	mckie	mckie	NOUN
biomedich-495	30	61	et	et	NOUN
biomedich-495	30	62	al	al	PROPN
biomedich-495	30	63	.	.	PROPN
biomedich-495	30	64	,	,	PUNCT
biomedich-495	30	65	2021	2021	NUM
biomedich-495	30	66	)	)	PUNCT
biomedich-495	30	67	.	.	PUNCT
biomedich-495	31	1	dna	dna	PROPN
biomedich-495	31	2	's	's	PART
biomedich-495	31	3	double	double	ADJ
biomedich-495	31	4	helix	helix	NOUN
biomedich-495	31	5	structure	structure	NOUN
biomedich-495	31	6	is	be	AUX
biomedich-495	31	7	entangled	entangle	VERB
biomedich-495	31	8	,	,	PUNCT
biomedich-495	31	9	which	which	PRON
biomedich-495	31	10	can	can	AUX
biomedich-495	31	11	cause	cause	VERB
biomedich-495	31	12	topological	topological	ADJ
biomedich-495	31	13	problems	problem	NOUN
biomedich-495	31	14	.	.	PUNCT
biomedich-495	32	1	overwinding	overwinde	VERB
biomedich-495	32	2	of	of	ADP
biomedich-495	32	3	the	the	DET
biomedich-495	32	4	dna	dna	PROPN
biomedich-495	32	5	duplex	duplex	NOUN
biomedich-495	32	6	can	can	AUX
biomedich-495	32	7	occur	occur	VERB
biomedich-495	32	8	during	during	ADP
biomedich-495	32	9	transcription	transcription	NOUN
biomedich-495	32	10	and	and	CCONJ
biomedich-495	32	11	replication	replication	NOUN
biomedich-495	32	12	,	,	PUNCT
biomedich-495	32	13	for	for	ADP
biomedich-495	32	14	example	example	NOUN
biomedich-495	32	15	.	.	PUNCT
biomedich-495	33	1	this	this	DET
biomedich-495	33	2	torsion	torsion	NOUN
biomedich-495	33	3	would	would	AUX
biomedich-495	33	4	eventually	eventually	ADV
biomedich-495	33	5	prevent	prevent	VERB
biomedich-495	33	6	the	the	DET
biomedich-495	33	7	dna	dna	PROPN
biomedich-495	33	8	or	or	CCONJ
biomedich-495	33	9	rna	rna	NOUN
biomedich-495	33	10	polymerases	polymerase	NOUN
biomedich-495	33	11	engaged	engage	VERB
biomedich-495	33	12	in	in	ADP
biomedich-495	33	13	these	these	DET
biomedich-495	33	14	activities	activity	NOUN
biomedich-495	33	15	from	from	ADP
biomedich-495	33	16	moving	move	VERB
biomedich-495	33	17	further	far	ADV
biomedich-495	33	18	along	along	ADP
biomedich-495	33	19	the	the	DET
biomedich-495	33	20	dna	dna	PROPN
biomedich-495	33	21	helix	helix	NOUN
biomedich-495	33	22	if	if	SCONJ
biomedich-495	33	23	left	leave	VERB
biomedich-495	33	24	unaltered	unaltered	ADJ
biomedich-495	33	25	.	.	PUNCT
biomedich-495	34	1	replication	replication	NOUN
biomedich-495	34	2	-	-	PUNCT
biomedich-495	34	3	related	relate	VERB
biomedich-495	34	4	dna	dna	NOUN
biomedich-495	34	5	tangling	tangle	VERB
biomedich-495	34	6	or	or	CCONJ
biomedich-495	34	7	linking	link	VERB
biomedich-495	34	8	presents	present	VERB
biomedich-495	34	9	a	a	DET
biomedich-495	34	10	second	second	ADJ
biomedich-495	34	11	topological	topological	ADJ
biomedich-495	34	12	problem	problem	NOUN
biomedich-495	34	13	.	.	PUNCT
biomedich-495	35	1	links	link	NOUN
biomedich-495	35	2	between	between	ADP
biomedich-495	35	3	replicated	replicate	VERB
biomedich-495	35	4	dna	dna	NOUN
biomedich-495	35	5	will	will	AUX
biomedich-495	35	6	prevent	prevent	VERB
biomedich-495	35	7	cells	cell	NOUN
biomedich-495	35	8	from	from	ADP
biomedich-495	35	9	dividing	divide	VERB
biomedich-495	35	10	if	if	SCONJ
biomedich-495	35	11	they	they	PRON
biomedich-495	35	12	remain	remain	VERB
biomedich-495	35	13	unbroken	unbroken	ADJ
biomedich-495	35	14	.	.	PUNCT
biomedich-495	36	1	these	these	DET
biomedich-495	36	2	kinds	kind	NOUN
biomedich-495	36	3	of	of	ADP
biomedich-495	36	4	topological	topological	ADJ
biomedich-495	36	5	issues	issue	NOUN
biomedich-495	36	6	are	be	AUX
biomedich-495	36	7	avoided	avoid	VERB
biomedich-495	36	8	and	and	CCONJ
biomedich-495	36	9	resolved	resolve	VERB
biomedich-495	36	10	by	by	ADP
biomedich-495	36	11	the	the	DET
biomedich-495	36	12	dna	dna	PROPN
biomedich-495	36	13	topoisomerases	topoisomerase	NOUN
biomedich-495	36	14	(	(	PUNCT
biomedich-495	36	15	sutormin	sutormin	VERB
biomedich-495	36	16	et	et	PROPN
biomedich-495	36	17	al	al	PROPN
biomedich-495	36	18	.	.	PROPN
biomedich-495	36	19	,	,	PUNCT
biomedich-495	36	20	2021	2021	NUM
biomedich-495	36	21	)	)	PUNCT
biomedich-495	36	22	.	.	PUNCT
biomedich-495	37	1	gyrase	gyrase	NOUN
biomedich-495	37	2	and	and	CCONJ
biomedich-495	37	3	topoisomerase	topoisomerase	NOUN
biomedich-495	37	4	iv	iv	NUM
biomedich-495	37	5	are	be	AUX
biomedich-495	37	6	two	two	NUM
biomedich-495	37	7	type	type	NOUN
biomedich-495	37	8	ii	ii	NOUN
biomedich-495	37	9	topoisomerases	topoisomerase	NOUN
biomedich-495	37	10	that	that	PRON
biomedich-495	37	11	are	be	AUX
biomedich-495	37	12	involved	involve	VERB
biomedich-495	37	13	in	in	ADP
biomedich-495	37	14	facilitating	facilitate	VERB
biomedich-495	37	15	dna	dna	NOUN
biomedich-495	37	16	replication	replication	NOUN
biomedich-495	37	17	and	and	CCONJ
biomedich-495	37	18	timely	timely	ADJ
biomedich-495	37	19	dna	dna	PROPN
biomedich-495	37	20	segregation	segregation	NOUN
biomedich-495	37	21	in	in	ADP
biomedich-495	37	22	escherichia	escherichia	NOUN
biomedich-495	37	23	coli	coli	NOUN
biomedich-495	37	24	.	.	PUNCT
biomedich-495	38	1	these	these	DET
biomedich-495	38	2	two	two	NUM
biomedich-495	38	3	enzymes	enzyme	NOUN
biomedich-495	38	4	function	function	NOUN
biomedich-495	38	5	by	by	ADP
biomedich-495	38	6	causing	cause	VERB
biomedich-495	38	7	a	a	DET
biomedich-495	38	8	temporary	temporary	ADJ
biomedich-495	38	9	double	double	ADJ
biomedich-495	38	10	strand	strand	NOUN
biomedich-495	38	11	break	break	NOUN
biomedich-495	38	12	in	in	ADP
biomedich-495	38	13	a	a	DET
biomedich-495	38	14	single	single	ADJ
biomedich-495	38	15	molecule	molecule	NOUN
biomedich-495	38	16	,	,	PUNCT
biomedich-495	38	17	guiding	guide	VERB
biomedich-495	38	18	a	a	DET
biomedich-495	38	19	second	second	ADJ
biomedich-495	38	20	dna	dna	PROPN
biomedich-495	38	21	duplex	duplex	NOUN
biomedich-495	38	22	through	through	ADP
biomedich-495	38	23	the	the	DET
biomedich-495	38	24	cut	cut	NOUN
biomedich-495	38	25	,	,	PUNCT
biomedich-495	38	26	and	and	CCONJ
biomedich-495	38	27	then	then	ADV
biomedich-495	38	28	closing	close	VERB
biomedich-495	38	29	the	the	DET
biomedich-495	38	30	cut	cut	NOUN
biomedich-495	38	31	again	again	ADV
biomedich-495	38	32	(	(	PUNCT
biomedich-495	38	33	schoeffler	schoeffler	NOUN
biomedich-495	38	34	&	&	CCONJ
biomedich-495	38	35	berger	berger	PROPN
biomedich-495	38	36	,	,	PUNCT
biomedich-495	38	37	2008	2008	NUM
biomedich-495	38	38	)	)	PUNCT
biomedich-495	38	39	.	.	PUNCT
biomedich-495	39	1	figure	figure	NOUN
biomedich-495	39	2	1	1	NUM
biomedich-495	39	3	.	.	PUNCT
biomedich-495	40	1	(	(	PUNCT
biomedich-495	40	2	a	a	NOUN
biomedich-495	40	3	)	)	PUNCT
biomedich-495	40	4	.	.	PUNCT
biomedich-495	41	1	crystal	crystal	NOUN
biomedich-495	41	2	structure	structure	NOUN
biomedich-495	41	3	of	of	ADP
biomedich-495	41	4	escherichia	escherichia	NOUN
biomedich-495	41	5	coli	coli	NOUN
biomedich-495	41	6	topoisomerase	topoisomerase	NOUN
biomedich-495	41	7	iv	iv	NUM
biomedich-495	41	8	pare	pare	NOUN
biomedich-495	41	9	24kda	24kda	NOUN
biomedich-495	41	10	subunit	subunit	NOUN
biomedich-495	41	11	;	;	PUNCT
biomedich-495	41	12	rcsb	rcsb	VERB
biomedich-495	41	13	pdb	pdb	PROPN
biomedich-495	41	14	1s14	1s14	NOUN
biomedich-495	41	15	:	:	PUNCT
biomedich-495	41	16	crystal	crystal	NOUN
biomedich-495	41	17	structure	structure	NOUN
biomedich-495	41	18	of	of	ADP
biomedich-495	41	19	escherichia	escherichia	NOUN
biomedich-495	41	20	coli	coli	NOUN
biomedich-495	41	21	topoisomerase	topoisomerase	NOUN
biomedich-495	41	22	iv	iv	NUM
biomedich-495	41	23	pare	pare	NOUN
biomedich-495	41	24	24kda	24kda	NOUN
biomedich-495	41	25	subunit	subunit	NOUN
biomedich-495	41	26	(	(	PUNCT
biomedich-495	41	27	b	b	NOUN
biomedich-495	41	28	)	)	PUNCT
biomedich-495	41	29	.	.	PUNCT
biomedich-495	42	1	ramachandran	ramachandran	PROPN
biomedich-495	42	2	plot	plot	NOUN
biomedich-495	42	3	of	of	ADP
biomedich-495	42	4	topoisomerase	topoisomerase	NOUN
biomedich-495	42	5	iv	iv	NUM
biomedich-495	42	6	pare	pare	NOUN
biomedich-495	42	7	.	.	PUNCT
biomedich-495	43	1	antibacterial	antibacterial	ADJ
biomedich-495	43	2	drugs	drug	NOUN
biomedich-495	43	3	based	base	VERB
biomedich-495	43	4	on	on	ADP
biomedich-495	43	5	quinolones	quinolone	NOUN
biomedich-495	43	6	target	target	VERB
biomedich-495	43	7	dna	dna	NOUN
biomedich-495	43	8	gyrase	gyrase	NOUN
biomedich-495	43	9	and	and	CCONJ
biomedich-495	43	10	topoisomerase	topoisomerase	NOUN
biomedich-495	43	11	iv	iv	NOUN
biomedich-495	43	12	.	.	PUNCT
biomedich-495	44	1	the	the	DET
biomedich-495	44	2	most	most	ADV
biomedich-495	44	3	potent	potent	ADJ
biomedich-495	44	4	and	and	CCONJ
biomedich-495	44	5	versatile	versatile	ADJ
biomedich-495	44	6	oral	oral	ADJ
biomedich-495	44	7	antibacterial	antibacterial	ADJ
biomedich-495	44	8	medications	medication	NOUN
biomedich-495	44	9	now	now	ADV
biomedich-495	44	10	being	be	AUX
biomedich-495	44	11	used	use	VERB
biomedich-495	44	12	in	in	ADP
biomedich-495	44	13	clinical	clinical	ADJ
biomedich-495	44	14	settings	setting	NOUN
biomedich-495	44	15	are	be	AUX
biomedich-495	44	16	quinolones	quinolone	NOUN
biomedich-495	44	17	.	.	PUNCT
biomedich-495	45	1	medications	medication	NOUN
biomedich-495	45	2	like	like	ADP
biomedich-495	45	3	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	45	4	are	be	AUX
biomedich-495	45	5	frequently	frequently	ADV
biomedich-495	45	6	used	use	VERB
biomedich-495	45	7	to	to	PART
biomedich-495	45	8	treat	treat	VERB
biomedich-495	45	9	a	a	DET
biomedich-495	45	10	range	range	NOUN
biomedich-495	45	11	of	of	ADP
biomedich-495	45	12	gram	gram	NOUN
biomedich-495	45	13	-	-	PUNCT
biomedich-495	45	14	negative	negative	ADJ
biomedich-495	45	15	bacterial	bacterial	ADJ
biomedich-495	45	16	infections	infection	NOUN
biomedich-495	45	17	,	,	PUNCT
biomedich-495	45	18	such	such	ADJ
biomedich-495	45	19	as	as	ADP
biomedich-495	45	20	infections	infection	NOUN
biomedich-495	45	21	of	of	ADP
biomedich-495	45	22	the	the	DET
biomedich-495	45	23	gastrointestinal	gastrointestinal	ADJ
biomedich-495	45	24	tract	tract	NOUN
biomedich-495	45	25	,	,	PUNCT
biomedich-495	45	26	bones	bone	NOUN
biomedich-495	45	27	,	,	PUNCT
biomedich-495	45	28	and	and	CCONJ
biomedich-495	45	29	joints	joint	NOUN
biomedich-495	45	30	(	(	PUNCT
biomedich-495	45	31	gentry	gentry	NOUN
biomedich-495	45	32	&	&	CCONJ
biomedich-495	45	33	osheroff	osheroff	NOUN
biomedich-495	45	34	,	,	PUNCT
biomedich-495	45	35	2013	2013	NUM
biomedich-495	45	36	)	)	PUNCT
biomedich-495	45	37	.	.	PUNCT
biomedich-495	46	1	materials	material	NOUN
biomedich-495	46	2	and	and	CCONJ
biomedich-495	46	3	methods	method	NOUN
biomedich-495	46	4	data	datum	NOUN
biomedich-495	46	5	collection	collection	NOUN
biomedich-495	46	6	and	and	CCONJ
biomedich-495	46	7	ligand	ligand	ADJ
biomedich-495	46	8	preparation	preparation	NOUN
biomedich-495	46	9	the	the	DET
biomedich-495	46	10	approach	approach	NOUN
biomedich-495	46	11	commenced	commence	VERB
biomedich-495	46	12	with	with	ADP
biomedich-495	46	13	a	a	DET
biomedich-495	46	14	comprehensive	comprehensive	ADJ
biomedich-495	46	15	literature	literature	NOUN
biomedich-495	46	16	survey	survey	NOUN
biomedich-495	46	17	aimed	aim	VERB
biomedich-495	46	18	at	at	ADP
biomedich-495	46	19	identifying	identify	VERB
biomedich-495	46	20	optimal	optimal	ADJ
biomedich-495	46	21	secondary	secondary	ADJ
biomedich-495	46	22	metabolites	metabolite	NOUN
biomedich-495	46	23	for	for	ADP
biomedich-495	46	24	study	study	NOUN
biomedich-495	46	25	.	.	PUNCT
biomedich-495	47	1	upon	upon	SCONJ
biomedich-495	47	2	selection	selection	NOUN
biomedich-495	47	3	,	,	PUNCT
biomedich-495	47	4	the	the	DET
biomedich-495	47	5	3d	3d	PROPN
biomedich-495	47	6	chemical	chemical	NOUN
biomedich-495	47	7	structures	structure	NOUN
biomedich-495	47	8	of	of	ADP
biomedich-495	47	9	these	these	DET
biomedich-495	47	10	chosen	choose	VERB
biomedich-495	47	11	secondary	secondary	ADJ
biomedich-495	47	12	molecules	molecule	NOUN
biomedich-495	47	13	were	be	AUX
biomedich-495	47	14	procured	procure	VERB
biomedich-495	47	15	from	from	ADP
biomedich-495	47	16	the	the	DET
biomedich-495	47	17	pubchem	pubchem	NOUN
biomedich-495	47	18	database	database	NOUN
biomedich-495	47	19	,	,	PUNCT
biomedich-495	47	20	and	and	CCONJ
biomedich-495	47	21	the	the	DET
biomedich-495	47	22	data	datum	NOUN
biomedich-495	47	23	were	be	AUX
biomedich-495	47	24	acquired	acquire	VERB
biomedich-495	47	25	in	in	ADP
biomedich-495	47	26	.sdf	.sdf	NOUN
biomedich-495	47	27	format	format	NOUN
biomedich-495	47	28	.	.	PUNCT
biomedich-495	48	1	to	to	PART
biomedich-495	48	2	ensure	ensure	VERB
biomedich-495	48	3	compatibility	compatibility	NOUN
biomedich-495	48	4	with	with	ADP
biomedich-495	48	5	physiological	physiological	ADJ
biomedich-495	48	6	conditions	condition	NOUN
biomedich-495	48	7	,	,	PUNCT
biomedich-495	48	8	the	the	DET
biomedich-495	48	9	retrieved	retrieve	VERB
biomedich-495	48	10	chemical	chemical	NOUN
biomedich-495	48	11	structures	structure	NOUN
biomedich-495	48	12	were	be	AUX
biomedich-495	48	13	imported	import	VERB
biomedich-495	48	14	into	into	ADP
biomedich-495	48	15	avogadro	avogadro	PRON
biomedich-495	48	16	v.1.2.0	v.1.2.0	PROPN
biomedich-495	48	17	software	software	NOUN
biomedich-495	48	18	.	.	PUNCT
biomedich-495	49	1	subsequently	subsequently	ADV
biomedich-495	49	2	,	,	PUNCT
biomedich-495	49	3	adjustments	adjustment	NOUN
biomedich-495	49	4	were	be	AUX
biomedich-495	49	5	made	make	VERB
biomedich-495	49	6	to	to	PART
biomedich-495	49	7	achieve	achieve	VERB
biomedich-495	49	8	the	the	DET
biomedich-495	49	9	appropriate	appropriate	ADJ
biomedich-495	49	10	protonation	protonation	NOUN
biomedich-495	49	11	states	state	NOUN
biomedich-495	49	12	,	,	PUNCT
biomedich-495	49	13	and	and	CCONJ
biomedich-495	49	14	energy	energy	NOUN
biomedich-495	49	15	minimization	minimization	NOUN
biomedich-495	49	16	was	be	AUX
biomedich-495	49	17	performed	perform	VERB
biomedich-495	49	18	leveraging	leverage	VERB
biomedich-495	49	19	the	the	DET
biomedich-495	49	20	universal	universal	ADJ
biomedich-495	49	21	force	force	NOUN
biomedich-495	49	22	field	field	NOUN
biomedich-495	49	23	,	,	PUNCT
biomedich-495	49	24	utilizing	utilize	VERB
biomedich-495	49	25	a	a	DET
biomedich-495	49	26	conjugate	conjugate	ADJ
biomedich-495	49	27	gradient	gradient	ADJ
biomedich-495	49	28	algorithm	algorithm	NOUN
biomedich-495	49	29	for	for	ADP
biomedich-495	49	30	500	500	NUM
biomedich-495	49	31	steps	step	NOUN
biomedich-495	49	32	.	.	PUNCT
biomedich-495	50	1	for	for	ADP
biomedich-495	50	2	compatibility	compatibility	NOUN
biomedich-495	50	3	with	with	ADP
biomedich-495	50	4	downstream	downstream	ADJ
biomedich-495	50	5	processes	process	NOUN
biomedich-495	50	6	and	and	CCONJ
biomedich-495	50	7	analyses	analysis	NOUN
biomedich-495	50	8	,	,	PUNCT
biomedich-495	50	9	the	the	DET
biomedich-495	50	10	prepared	prepare	VERB
biomedich-495	50	11	ligands	ligand	NOUN
biomedich-495	50	12	transformed	transform	VERB
biomedich-495	50	13	and	and	CCONJ
biomedich-495	50	14	were	be	AUX
biomedich-495	50	15	saved	save	VERB
biomedich-495	50	16	in	in	ADP
biomedich-495	50	17	the	the	DET
biomedich-495	50	18	.pdbqt	.pdbqt	NOUN
biomedich-495	50	19	format	format	NOUN
biomedich-495	50	20	.	.	PUNCT
biomedich-495	51	1	the	the	DET
biomedich-495	51	2	openbabelgui	openbabelgui	PROPN
biomedich-495	51	3	tool	tool	PROPN
biomedich-495	51	4	played	play	VERB
biomedich-495	51	5	a	a	DET
biomedich-495	51	6	pivotal	pivotal	ADJ
biomedich-495	51	7	role	role	NOUN
biomedich-495	51	8	in	in	ADP
biomedich-495	51	9	facilitating	facilitate	VERB
biomedich-495	51	10	file	file	NOUN
biomedich-495	51	11	format	format	NOUN
biomedich-495	51	12	conversion	conversion	NOUN
biomedich-495	51	13	,	,	PUNCT
biomedich-495	51	14	ensuring	ensure	VERB
biomedich-495	51	15	seamless	seamless	ADJ
biomedich-495	51	16	integration	integration	NOUN
biomedich-495	51	17	of	of	ADP
biomedich-495	51	18	the	the	DET
biomedich-495	51	19	ligands	ligand	NOUN
biomedich-495	51	20	into	into	ADP
biomedich-495	51	21	the	the	DET
biomedich-495	51	22	subsequent	subsequent	ADJ
biomedich-495	51	23	stages	stage	NOUN
biomedich-495	51	24	of	of	ADP
biomedich-495	51	25	our	our	PRON
biomedich-495	51	26	research	research	NOUN
biomedich-495	51	27	.	.	PUNCT
biomedich-495	52	1	this	this	DET
biomedich-495	52	2	meticulous	meticulous	ADJ
biomedich-495	52	3	process	process	NOUN
biomedich-495	52	4	of	of	ADP
biomedich-495	52	5	data	datum	NOUN
biomedich-495	52	6	collection	collection	NOUN
biomedich-495	52	7	and	and	CCONJ
biomedich-495	52	8	ligand	ligand	ADJ
biomedich-495	52	9	preparation	preparation	NOUN
biomedich-495	52	10	lays	lay	VERB
biomedich-495	52	11	the	the	DET
biomedich-495	52	12	foundation	foundation	NOUN
biomedich-495	52	13	for	for	ADP
biomedich-495	52	14	robust	robust	ADJ
biomedich-495	52	15	molecular	molecular	ADJ
biomedich-495	52	16	analyses	analysis	NOUN
biomedich-495	52	17	,	,	PUNCT
biomedich-495	52	18	allowing	allow	VERB
biomedich-495	52	19	for	for	ADP
biomedich-495	52	20	accurate	accurate	ADJ
biomedich-495	52	21	and	and	CCONJ
biomedich-495	52	22	reliable	reliable	ADJ
biomedich-495	52	23	investigations	investigation	NOUN
biomedich-495	52	24	into	into	ADP
biomedich-495	52	25	the	the	DET
biomedich-495	52	26	interactions	interaction	NOUN
biomedich-495	52	27	and	and	CCONJ
biomedich-495	52	28	behaviors	behavior	NOUN
biomedich-495	52	29	of	of	ADP
biomedich-495	52	30	the	the	DET
biomedich-495	52	31	selected	select	VERB
biomedich-495	52	32	secondary	secondary	ADJ
biomedich-495	52	33	metabolites	metabolite	NOUN
biomedich-495	52	34	.	.	PUNCT
biomedich-495	53	1	protein	protein	NOUN
biomedich-495	53	2	preparations	preparation	NOUN
biomedich-495	53	3	crystal	crystal	NOUN
biomedich-495	53	4	structure	structure	NOUN
biomedich-495	53	5	of	of	ADP
biomedich-495	53	6	escherichia	escherichia	NOUN
biomedich-495	53	7	coli	coli	NOUN
biomedich-495	53	8	topoisomerase	topoisomerase	NOUN
biomedich-495	53	9	iv	iv	NUM
biomedich-495	53	10	pare	pare	NOUN
biomedich-495	53	11	24kda	24kda	NOUN
biomedich-495	53	12	subunit	subunit	NOUN
biomedich-495	53	13	–	–	PUNCT
biomedich-495	53	14	pdb	pdb	PROPN
biomedich-495	53	15	id-1s14	id-1s14	NOUN
biomedich-495	53	16	were	be	AUX
biomedich-495	53	17	obtained	obtain	VERB
biomedich-495	53	18	from	from	ADP
biomedich-495	53	19	protein	protein	NOUN
biomedich-495	53	20	data	datum	NOUN
biomedich-495	53	21	bank	bank	NOUN
biomedich-495	53	22	in	in	ADP
biomedich-495	53	23	.pdb	.pdb	PROPN
biomedich-495	53	24	format	format	NOUN
biomedich-495	53	25	.	.	PUNCT
biomedich-495	54	1	protein	protein	NOUN
biomedich-495	54	2	preparation	preparation	NOUN
biomedich-495	54	3	was	be	AUX
biomedich-495	54	4	done	do	VERB
biomedich-495	54	5	using	use	VERB
biomedich-495	54	6	autodocktools	autodocktools	PROPN
biomedich-495	54	7	version	version	NOUN
biomedich-495	54	8	1.5.7	1.5.7	NUM
biomedich-495	54	9	.	.	PUNCT
biomedich-495	55	1	the	the	DET
biomedich-495	55	2	water	water	NOUN
biomedich-495	55	3	molecules	molecule	NOUN
biomedich-495	55	4	and	and	CCONJ
biomedich-495	55	5	heteroatoms	heteroatom	NOUN
biomedich-495	55	6	were	be	AUX
biomedich-495	55	7	deleted	delete	VERB
biomedich-495	55	8	.	.	PUNCT
biomedich-495	56	1	missing	miss	VERB
biomedich-495	56	2	atoms	atom	NOUN
biomedich-495	56	3	were	be	AUX
biomedich-495	56	4	repaired	repair	VERB
biomedich-495	56	5	.	.	PUNCT
biomedich-495	57	1	polar	polar	ADJ
biomedich-495	57	2	hydrogens	hydrogen	NOUN
biomedich-495	57	3	and	and	CCONJ
biomedich-495	57	4	kollman	kollman	NOUN
biomedich-495	57	5	charges	charge	NOUN
biomedich-495	57	6	were	be	AUX
biomedich-495	57	7	added	add	VERB
biomedich-495	57	8	to	to	ADP
biomedich-495	57	9	the	the	DET
biomedich-495	57	10	protein	protein	NOUN
biomedich-495	57	11	.	.	PUNCT
biomedich-495	58	1	molecular	molecular	ADJ
biomedich-495	58	2	docking	dock	VERB
biomedich-495	58	3	the	the	DET
biomedich-495	58	4	grid	grid	NOUN
biomedich-495	58	5	parameters	parameter	NOUN
biomedich-495	58	6	and	and	CCONJ
biomedich-495	58	7	map	map	VERB
biomedich-495	58	8	files	file	NOUN
biomedich-495	58	9	were	be	AUX
biomedich-495	58	10	created	create	VERB
biomedich-495	58	11	using	use	VERB
biomedich-495	58	12	autogrid	autogrid	ADJ
biomedich-495	58	13	4.2	4.2	NUM
biomedich-495	58	14	.	.	PUNCT
biomedich-495	59	1	to	to	PART
biomedich-495	59	2	perform	perform	VERB
biomedich-495	59	3	the	the	DET
biomedich-495	59	4	blind	blind	ADJ
biomedich-495	59	5	docking	docking	NOUN
biomedich-495	59	6	.	.	PUNCT
biomedich-495	60	1	(	(	PUNCT
biomedich-495	60	2	genetic	genetic	ADJ
biomedich-495	60	3	algorithm	algorithm	NOUN
biomedich-495	60	4	parameters	parameter	NOUN
biomedich-495	60	5	settings	setting	NOUN
biomedich-495	60	6	:	:	PUNCT
biomedich-495	60	7	number	number	NOUN
biomedich-495	60	8	of	of	ADP
biomedich-495	60	9	genetic	genetic	ADJ
biomedich-495	60	10	algorithm	algorithm	NOUN
biomedich-495	60	11	(	(	PUNCT
biomedich-495	60	12	ga	ga	NOUN
biomedich-495	60	13	)	)	PUNCT
biomedich-495	60	14	runs	run	NOUN
biomedich-495	60	15	:	:	PUNCT
biomedich-495	60	16	50	50	NUM
biomedich-495	60	17	,	,	PUNCT
biomedich-495	60	18	population	population	NOUN
biomedich-495	60	19	size	size	NOUN
biomedich-495	60	20	:	:	PUNCT
biomedich-495	60	21	300	300	NUM
biomedich-495	60	22	,	,	PUNCT
biomedich-495	60	23	the	the	DET
biomedich-495	60	24	maximum	maximum	ADJ
biomedich-495	60	25	number	number	NOUN
biomedich-495	60	26	of	of	ADP
biomedich-495	60	27	evaluations	evaluation	NOUN
biomedich-495	60	28	:	:	PUNCT
biomedich-495	60	29	25	25	NUM
biomedich-495	60	30	000	000	NUM
biomedich-495	60	31	000	000	NUM
biomedich-495	60	32	(	(	PUNCT
biomedich-495	60	33	medium	medium	NOUN
biomedich-495	60	34	)	)	PUNCT
biomedich-495	60	35	,	,	PUNCT
biomedich-495	60	36	and	and	CCONJ
biomedich-495	60	37	maximum	maximum	ADJ
biomedich-495	60	38	number	number	NOUN
biomedich-495	60	39	of	of	ADP
biomedich-495	60	40	generations	generation	NOUN
biomedich-495	60	41	:	:	PUNCT
biomedich-495	60	42	27	27	NUM
biomedich-495	60	43	000	000	NUM
biomedich-495	60	44	)	)	PUNCT
biomedich-495	60	45	.	.	PUNCT
biomedich-495	61	1	molecular	molecular	ADJ
biomedich-495	61	2	docking	docking	NOUN
biomedich-495	61	3	was	be	AUX
biomedich-495	61	4	performed	perform	VERB
biomedich-495	61	5	using	use	VERB
biomedich-495	61	6	autodock	autodock	NOUN
biomedich-495	61	7	4.2	4.2	NUM
biomedich-495	61	8	,	,	PUNCT
biomedich-495	61	9	and	and	CCONJ
biomedich-495	61	10	results	result	NOUN
biomedich-495	61	11	were	be	AUX
biomedich-495	61	12	generated	generate	VERB
biomedich-495	61	13	in	in	ADP
biomedich-495	61	14	.dlg	.dlg	PROPN
biomedich-495	61	15	format	format	NOUN
biomedich-495	61	16	(	(	PUNCT
biomedich-495	61	17	output	output	NOUN
biomedich-495	61	18	–	–	PUNCT
biomedich-495	61	19	lamarckian	lamarckian	ADJ
biomedich-495	61	20	ga-4.2	ga-4.2	NOUN
biomedich-495	61	21	)	)	PUNCT
biomedich-495	61	22	(	(	PUNCT
biomedich-495	61	23	lawan	lawan	PROPN
biomedich-495	61	24	&	&	CCONJ
biomedich-495	61	25	tharakee	tharakee	PROPN
biomedich-495	61	26	,	,	PUNCT
biomedich-495	61	27	2023	2023	NUM
biomedich-495	61	28	)	)	PUNCT
biomedich-495	61	29	.	.	PUNCT
biomedich-495	62	1	a	a	PRON
biomedich-495	62	2	b	b	PROPN
biomedich-495	62	3	perera	perera	PROPN
biomedich-495	62	4	&	&	CCONJ
biomedich-495	62	5	lawan	lawan	PROPN
biomedich-495	62	6	–	–	PUNCT
biomedich-495	62	7	antibacterial	antibacterial	ADJ
biomedich-495	62	8	potential	potential	NOUN
biomedich-495	62	9	of	of	ADP
biomedich-495	62	10	hygrophila	hygrophila	PROPN
biomedich-495	62	11	schulli	schulli	PROPN
biomedich-495	62	12	207	207	NUM
biomedich-495	62	13	interaction	interaction	NOUN
biomedich-495	62	14	visualization	visualization	NOUN
biomedich-495	62	15	and	and	CCONJ
biomedich-495	62	16	analysis	analysis	NOUN
biomedich-495	62	17	docking	docking	NOUN
biomedich-495	62	18	results	result	NOUN
biomedich-495	62	19	were	be	AUX
biomedich-495	62	20	analyzed	analyze	VERB
biomedich-495	62	21	using	use	VERB
biomedich-495	62	22	autodocktools	autodocktool	NOUN
biomedich-495	62	23	version	version	NOUN
biomedich-495	62	24	1.5.6	1.5.6	NUM
biomedich-495	62	25	to	to	PART
biomedich-495	62	26	examine	examine	VERB
biomedich-495	62	27	the	the	DET
biomedich-495	62	28	binding	bind	VERB
biomedich-495	62	29	energies	energy	NOUN
biomedich-495	62	30	and	and	CCONJ
biomedich-495	62	31	inhibition	inhibition	NOUN
biomedich-495	62	32	constants	constant	NOUN
biomedich-495	62	33	.	.	PUNCT
biomedich-495	63	1	binding	bind	VERB
biomedich-495	63	2	interactions	interaction	NOUN
biomedich-495	63	3	with	with	ADP
biomedich-495	63	4	the	the	DET
biomedich-495	63	5	ligand	ligand	NOUN
biomedich-495	63	6	were	be	AUX
biomedich-495	63	7	visualized	visualize	VERB
biomedich-495	63	8	using	use	VERB
biomedich-495	63	9	the	the	DET
biomedich-495	63	10	discovery	discovery	NOUN
biomedich-495	63	11	studio	studio	NOUN
biomedich-495	63	12	2021	2021	NUM
biomedich-495	63	13	client	client	NOUN
biomedich-495	63	14	.	.	PUNCT
biomedich-495	64	1	protein	protein	NOUN
biomedich-495	64	2	-	-	PUNCT
biomedich-495	64	3	ligand	ligand	NOUN
biomedich-495	64	4	interaction	interaction	NOUN
biomedich-495	64	5	profiler	profiler	NOUN
biomedich-495	64	6	(	(	PUNCT
biomedich-495	64	7	plip	plip	PROPN
biomedich-495	64	8	welcome	welcome	INTJ
biomedich-495	64	9	(	(	PUNCT
biomedich-495	64	10	tudresden.de	tudresden.de	NUM
biomedich-495	64	11	)	)	PUNCT
biomedich-495	64	12	)	)	PUNCT
biomedich-495	64	13	and	and	CCONJ
biomedich-495	64	14	proteins.plus	proteins.plus	NUM
biomedich-495	64	15	(	(	PUNCT
biomedich-495	64	16	zentrum	zentrum	X
biomedich-495	64	17	für	für	PROPN
biomedich-495	64	18	bioinformatik	bioinformatik	PROPN
biomedich-495	64	19	:	:	PUNCT
biomedich-495	64	20	universität	universität	ADJ
biomedich-495	64	21	hamburg	hamburg	NOUN
biomedich-495	64	22	-	-	PUNCT
biomedich-495	64	23	proteins	protein	NOUN
biomedich-495	64	24	plus	plus	CCONJ
biomedich-495	64	25	server	server	NOUN
biomedich-495	64	26	)	)	PUNCT
biomedich-495	64	27	web	web	NOUN
biomedich-495	64	28	servers	server	NOUN
biomedich-495	64	29	were	be	AUX
biomedich-495	64	30	also	also	ADV
biomedich-495	64	31	used	use	VERB
biomedich-495	64	32	to	to	PART
biomedich-495	64	33	further	far	ADV
biomedich-495	64	34	analyze	analyze	VERB
biomedich-495	64	35	the	the	DET
biomedich-495	64	36	binding	bind	VERB
biomedich-495	64	37	residues	residue	NOUN
biomedich-495	64	38	.	.	PUNCT
biomedich-495	65	1	in	in	ADP
biomedich-495	65	2	silico	silico	NOUN
biomedich-495	65	3	physicochemical	physicochemical	ADJ
biomedich-495	65	4	and	and	CCONJ
biomedich-495	65	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	65	6	parameter	parameter	NOUN
biomedich-495	65	7	prediction	prediction	NOUN
biomedich-495	65	8	veber	veber	PROPN
biomedich-495	65	9	's	's	PART
biomedich-495	65	10	rules	rule	NOUN
biomedich-495	65	11	(	(	PUNCT
biomedich-495	65	12	veber	veber	PROPN
biomedich-495	65	13	et	et	PROPN
biomedich-495	65	14	al	al	PROPN
biomedich-495	65	15	.	.	PROPN
biomedich-495	65	16	,	,	PUNCT
biomedich-495	65	17	2002	2002	NUM
biomedich-495	65	18	)	)	PUNCT
biomedich-495	65	19	and	and	CCONJ
biomedich-495	65	20	lipinski	lipinski	PROPN
biomedich-495	65	21	's	's	PART
biomedich-495	65	22	rule	rule	NOUN
biomedich-495	65	23	of	of	ADP
biomedich-495	65	24	five	five	NUM
biomedich-495	65	25	(	(	PUNCT
biomedich-495	65	26	lipinski	lipinski	PROPN
biomedich-495	65	27	et	et	PROPN
biomedich-495	65	28	al	al	PROPN
biomedich-495	65	29	.	.	PROPN
biomedich-495	65	30	,	,	PUNCT
biomedich-495	65	31	2001	2001	NUM
biomedich-495	65	32	)	)	PUNCT
biomedich-495	65	33	were	be	AUX
biomedich-495	65	34	applied	apply	VERB
biomedich-495	65	35	to	to	PART
biomedich-495	65	36	evaluate	evaluate	VERB
biomedich-495	65	37	druglikeness	druglikeness	NOUN
biomedich-495	65	38	using	use	VERB
biomedich-495	65	39	the	the	DET
biomedich-495	65	40	swissadme	swissadme	PROPN
biomedich-495	65	41	server	server	PROPN
biomedich-495	65	42	(	(	PUNCT
biomedich-495	65	43	swissadme	swissadme	NOUN
biomedich-495	65	44	)	)	PUNCT
biomedich-495	65	45	.	.	PUNCT
biomedich-495	66	1	secondary	secondary	ADJ
biomedich-495	66	2	metabolites	metabolite	NOUN
biomedich-495	66	3	given	give	VERB
biomedich-495	66	4	in	in	ADP
biomedich-495	66	5	table	table	NOUN
biomedich-495	66	6	1	1	NUM
biomedich-495	66	7	were	be	AUX
biomedich-495	66	8	analyzed	analyze	VERB
biomedich-495	66	9	for	for	ADP
biomedich-495	66	10	their	their	PRON
biomedich-495	66	11	physicochemical	physicochemical	ADJ
biomedich-495	66	12	properties	property	NOUN
biomedich-495	66	13	,	,	PUNCT
biomedich-495	66	14	and	and	CCONJ
biomedich-495	66	15	the	the	DET
biomedich-495	66	16	results	result	NOUN
biomedich-495	66	17	are	be	AUX
biomedich-495	66	18	epitomized	epitomize	VERB
biomedich-495	66	19	in	in	ADP
biomedich-495	66	20	table	table	NOUN
biomedich-495	66	21	2	2	NUM
biomedich-495	66	22	.	.	PUNCT
biomedich-495	67	1	the	the	DET
biomedich-495	67	2	admet	admet	PROPN
biomedich-495	67	3	characteristics	characteristic	NOUN
biomedich-495	67	4	of	of	ADP
biomedich-495	67	5	the	the	DET
biomedich-495	67	6	secondary	secondary	ADJ
biomedich-495	67	7	metabolites	metabolite	NOUN
biomedich-495	67	8	were	be	AUX
biomedich-495	67	9	studied	study	VERB
biomedich-495	67	10	using	use	VERB
biomedich-495	67	11	the	the	DET
biomedich-495	67	12	pkcsm	pkcsm	NOUN
biomedich-495	67	13	server	server	NOUN
biomedich-495	67	14	(	(	PUNCT
biomedich-495	67	15	pkcsm	pkcsm	NOUN
biomedich-495	67	16	(	(	PUNCT
biomedich-495	67	17	uq.edu.au	uq.edu.au	PROPN
biomedich-495	67	18	)	)	PUNCT
biomedich-495	67	19	)	)	PUNCT
biomedich-495	67	20	to	to	PART
biomedich-495	67	21	understand	understand	VERB
biomedich-495	67	22	their	their	PRON
biomedich-495	67	23	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	67	24	parameters	parameter	NOUN
biomedich-495	67	25	,	,	PUNCT
biomedich-495	67	26	and	and	CCONJ
biomedich-495	67	27	the	the	DET
biomedich-495	67	28	results	result	NOUN
biomedich-495	67	29	are	be	AUX
biomedich-495	67	30	given	give	VERB
biomedich-495	67	31	in	in	ADP
biomedich-495	67	32	table	table	NOUN
biomedich-495	67	33	3	3	NUM
biomedich-495	67	34	results	result	NOUN
biomedich-495	67	35	and	and	CCONJ
biomedich-495	67	36	discussion	discussion	NOUN
biomedich-495	67	37	table	table	NOUN
biomedich-495	67	38	1	1	NUM
biomedich-495	67	39	.	.	PUNCT
biomedich-495	67	40	calculated	calculate	VERB
biomedich-495	67	41	binding	bind	VERB
biomedich-495	67	42	energies	energy	NOUN
biomedich-495	67	43	and	and	CCONJ
biomedich-495	67	44	inhibition	inhibition	VERB
biomedich-495	67	45	constants	constant	NOUN
biomedich-495	67	46	of	of	ADP
biomedich-495	67	47	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	67	48	-	-	PUNCT
biomedich-495	67	49	a	a	NOUN
biomedich-495	67	50	and	and	CCONJ
biomedich-495	67	51	selected	select	VERB
biomedich-495	67	52	phytochemicals	phytochemical	NOUN
biomedich-495	67	53	.	.	PUNCT
biomedich-495	68	1	reference	reference	NOUN
biomedich-495	68	2	compound	compound	NOUN
biomedich-495	68	3	binding	bind	VERB
biomedich-495	68	4	energy	energy	NOUN
biomedich-495	68	5	/	/	SYM
biomedich-495	68	6	kcal	kcal	PROPN
biomedich-495	68	7	/	/	SYM
biomedich-495	68	8	mol	mol	ADP
biomedich-495	68	9	ki	ki	X
biomedich-495	68	10	-	-	PUNCT
biomedich-495	68	11	inhibition	inhibition	NOUN
biomedich-495	68	12	constant/	constant/	NUM
biomedich-495	68	13	µm	µm	ADP
biomedich-495	68	14	-4.21	-4.21	PROPN
biomedich-495	68	15	816.89	816.89	NUM
biomedich-495	68	16	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	68	17	\	\	NOUN
biomedich-495	68	18	compound	compound	NOUN
biomedich-495	68	19	binding	bind	VERB
biomedich-495	68	20	energy	energy	NOUN
biomedich-495	68	21	/	/	SYM
biomedich-495	68	22	kcal	kcal	NOUN
biomedich-495	68	23	/	/	SYM
biomedich-495	68	24	mol	mol	ADP
biomedich-495	68	25	kiinhibition	kiinhibition	NOUN
biomedich-495	68	26	constant/	constant/	NUM
biomedich-495	68	27	µm	µm	ADP
biomedich-495	68	28	compound	compound	NOUN
biomedich-495	68	29	binding	bind	VERB
biomedich-495	68	30	energy	energy	NOUN
biomedich-495	68	31	/	/	SYM
biomedich-495	68	32	kcal	kcal	NOUN
biomedich-495	68	33	/	/	SYM
biomedich-495	68	34	mol	mol	ADP
biomedich-495	68	35	kiinhibition	kiinhibition	NOUN
biomedich-495	68	36	constant/	constant/	NUM
biomedich-495	68	37	µm	µm	ADP
biomedich-495	68	38	ellagic	ellagic	PROPN
biomedich-495	68	39	acid	acid	PROPN
biomedich-495	68	40	-3.57	-3.57	NUM
biomedich-495	68	41	2430	2430	NUM
biomedich-495	68	42	lupeol	lupeol	NOUN
biomedich-495	68	43	-6.05	-6.05	NOUN
biomedich-495	68	44	37.27	37.27	NUM
biomedich-495	68	45	apigenin	apigenin	ADJ
biomedich-495	68	46	-4.65	-4.65	NUM
biomedich-495	68	47	393.37	393.37	NUM
biomedich-495	68	48	lupenone	lupenone	NOUN
biomedich-495	68	49	-6.15	-6.15	NOUN
biomedich-495	68	50	31.03	31.03	NUM
biomedich-495	68	51	quercetin	quercetin	NOUN
biomedich-495	68	52	-4.07	-4.07	NOUN
biomedich-495	68	53	1040	1040	NUM
biomedich-495	68	54	betulin	betulin	NOUN
biomedich-495	68	55	-5.40	-5.40	NUM
biomedich-495	68	56	109.28	109.28	NUM
biomedich-495	68	57	208	208	NUM
biomedich-495	68	58	biology	biology	NOUN
biomedich-495	68	59	,	,	PUNCT
biomedich-495	68	60	medicine	medicine	NOUN
biomedich-495	68	61	,	,	PUNCT
biomedich-495	68	62	&	&	CCONJ
biomedich-495	68	63	natural	natural	ADJ
biomedich-495	68	64	product	product	NOUN
biomedich-495	68	65	chemistry	chemistry	NOUN
biomedich-495	68	66	13	13	NUM
biomedich-495	68	67	(	(	PUNCT
biomedich-495	68	68	1	1	NUM
biomedich-495	68	69	)	)	PUNCT
biomedich-495	68	70	,	,	PUNCT
biomedich-495	68	71	2024	2024	NUM
biomedich-495	68	72	:	:	PUNCT
biomedich-495	68	73	205	205	NUM
biomedich-495	68	74	-	-	SYM
biomedich-495	68	75	214	214	NUM
biomedich-495	68	76	table	table	NOUN
biomedich-495	68	77	1	1	NUM
biomedich-495	68	78	.	.	PUNCT
biomedich-495	68	79	cont	cont	NOUN
biomedich-495	68	80	.	.	PUNCT
biomedich-495	69	1	compound	compound	NOUN
biomedich-495	69	2	binding	bind	VERB
biomedich-495	69	3	energy	energy	NOUN
biomedich-495	69	4	/	/	SYM
biomedich-495	69	5	kcal	kcal	NOUN
biomedich-495	69	6	/	/	SYM
biomedich-495	69	7	mol	mol	ADP
biomedich-495	69	8	kiinhibition	kiinhibition	NOUN
biomedich-495	69	9	constant/	constant/	NUM
biomedich-495	69	10	µm	µm	ADP
biomedich-495	69	11	compound	compound	NOUN
biomedich-495	69	12	binding	bind	VERB
biomedich-495	69	13	energy	energy	NOUN
biomedich-495	69	14	/	/	SYM
biomedich-495	69	15	kcal	kcal	NOUN
biomedich-495	69	16	/	/	SYM
biomedich-495	69	17	mol	mol	ADP
biomedich-495	69	18	kiinhibition	kiinhibition	NOUN
biomedich-495	69	19	constant/	constant/	NUM
biomedich-495	69	20	µm	µm	NOUN
biomedich-495	69	21	luteolin	luteolin	PROPN
biomedich-495	69	22	-4.58	-4.58	PUNCT
biomedich-495	69	23	435.83	435.83	NUM
biomedich-495	69	24	asterol	asterol	NOUN
biomedich-495	69	25	-4.40	-4.40	NUM
biomedich-495	69	26	593.30	593.30	NUM
biomedich-495	69	27	gallic	gallic	NOUN
biomedich-495	69	28	acid	acid	NOUN
biomedich-495	69	29	-3.81	-3.81	NUM
biomedich-495	69	30	1620	1620	NUM
biomedich-495	69	31	stigmasterol	stigmasterol	NOUN
biomedich-495	69	32	-5.23	-5.23	NUM
biomedich-495	69	33	145.80	145.80	NUM
biomedich-495	69	34	figure	figure	NOUN
biomedich-495	69	35	2	2	NUM
biomedich-495	69	36	.	.	PUNCT
biomedich-495	69	37	3d	3d	NUM
biomedich-495	69	38	visualization	visualization	NOUN
biomedich-495	69	39	of	of	ADP
biomedich-495	69	40	the	the	DET
biomedich-495	69	41	ligand	ligand	ADJ
biomedich-495	69	42	-	-	PUNCT
biomedich-495	69	43	protein	protein	NOUN
biomedich-495	69	44	complexes	complex	NOUN
biomedich-495	69	45	,	,	PUNCT
biomedich-495	69	46	(	(	PUNCT
biomedich-495	69	47	a	a	X
biomedich-495	69	48	)	)	PUNCT
biomedich-495	69	49	.	.	PUNCT
biomedich-495	70	1	apigenin	apigenin	PROPN
biomedich-495	70	2	(	(	PUNCT
biomedich-495	70	3	b	b	NOUN
biomedich-495	70	4	)	)	PUNCT
biomedich-495	70	5	.	.	PUNCT
biomedich-495	71	1	asterol	asterol	NOUN
biomedich-495	71	2	(	(	PUNCT
biomedich-495	71	3	c	c	NOUN
biomedich-495	71	4	)	)	PUNCT
biomedich-495	71	5	.	.	PUNCT
biomedich-495	72	1	butilin	butilin	NOUN
biomedich-495	72	2	(	(	PUNCT
biomedich-495	72	3	d	d	NOUN
biomedich-495	72	4	)	)	PUNCT
biomedich-495	72	5	.	.	PUNCT
biomedich-495	73	1	ciprofloxacin	ciprofloxacin	PROPN
biomedich-495	73	2	(	(	PUNCT
biomedich-495	73	3	e	e	NOUN
biomedich-495	73	4	)	)	PUNCT
biomedich-495	73	5	.	.	PUNCT
biomedich-495	74	1	ellagic	ellagic	ADJ
biomedich-495	74	2	acid	acid	NOUN
biomedich-495	74	3	(	(	PUNCT
biomedich-495	74	4	f	f	NOUN
biomedich-495	74	5	)	)	PUNCT
biomedich-495	74	6	.	.	PUNCT
biomedich-495	75	1	gallic	gallic	NOUN
biomedich-495	75	2	acid	acid	NOUN
biomedich-495	75	3	(	(	PUNCT
biomedich-495	75	4	g	g	NOUN
biomedich-495	75	5	)	)	PUNCT
biomedich-495	75	6	.	.	PUNCT
biomedich-495	76	1	lupenone	lupenone	NOUN
biomedich-495	76	2	(	(	PUNCT
biomedich-495	76	3	h	h	NOUN
biomedich-495	76	4	)	)	PUNCT
biomedich-495	76	5	.	.	PUNCT
biomedich-495	77	1	lupeol	lupeol	NOUN
biomedich-495	77	2	(	(	PUNCT
biomedich-495	77	3	i	i	NOUN
biomedich-495	77	4	)	)	PUNCT
biomedich-495	77	5	.	.	PUNCT
biomedich-495	78	1	quercetin	quercetin	NOUN
biomedich-495	78	2	(	(	PUNCT
biomedich-495	78	3	j	j	PROPN
biomedich-495	78	4	)	)	PUNCT
biomedich-495	78	5	.	.	PUNCT
biomedich-495	79	1	luteolin	luteolin	PROPN
biomedich-495	79	2	(	(	PUNCT
biomedich-495	79	3	k	k	NOUN
biomedich-495	79	4	)	)	PUNCT
biomedich-495	79	5	.	.	PUNCT
biomedich-495	80	1	stigmasterol	stigmasterol	NOUN
biomedich-495	80	2	obtained	obtain	VERB
biomedich-495	80	3	from	from	ADP
biomedich-495	80	4	discovery	discovery	NOUN
biomedich-495	80	5	studio	studio	NOUN
biomedich-495	80	6	2021	2021	NUM
biomedich-495	80	7	client	client	NOUN
biomedich-495	80	8	.	.	PUNCT
biomedich-495	81	1	a	a	DET
biomedich-495	81	2	b	b	X
biomedich-495	81	3	c	c	NOUN
biomedich-495	81	4	d	d	X
biomedich-495	81	5	e	e	X
biomedich-495	81	6	f	f	PROPN
biomedich-495	81	7	g	g	PROPN
biomedich-495	82	1	h	h	NOUN
biomedich-495	83	1	i	i	PRON
biomedich-495	83	2	j	j	PROPN
biomedich-495	84	1	k	k	PROPN
biomedich-495	84	2	perera	perera	PROPN
biomedich-495	84	3	&	&	CCONJ
biomedich-495	84	4	lawan	lawan	PROPN
biomedich-495	84	5	–	–	PUNCT
biomedich-495	84	6	antibacterial	antibacterial	ADJ
biomedich-495	84	7	potential	potential	NOUN
biomedich-495	84	8	of	of	ADP
biomedich-495	84	9	hygrophila	hygrophila	PROPN
biomedich-495	84	10	schulli	schulli	PROPN
biomedich-495	84	11	209	209	NUM
biomedich-495	84	12	figure	figure	NOUN
biomedich-495	84	13	3	3	NUM
biomedich-495	84	14	.	.	X
biomedich-495	84	15	diagram	diagram	NOUN
biomedich-495	84	16	showing	show	VERB
biomedich-495	84	17	the	the	DET
biomedich-495	84	18	amino	amino	NOUN
biomedich-495	84	19	acid	acid	NOUN
biomedich-495	84	20	residues	residue	NOUN
biomedich-495	84	21	that	that	PRON
biomedich-495	84	22	interact	interact	VERB
biomedich-495	84	23	with	with	ADP
biomedich-495	84	24	ligand	ligand	NOUN
biomedich-495	84	25	,	,	PUNCT
biomedich-495	84	26	(	(	PUNCT
biomedich-495	84	27	a	a	X
biomedich-495	84	28	)	)	PUNCT
biomedich-495	84	29	.	.	PUNCT
biomedich-495	85	1	apigenin	apigenin	PROPN
biomedich-495	85	2	(	(	PUNCT
biomedich-495	85	3	b	b	NOUN
biomedich-495	85	4	)	)	PUNCT
biomedich-495	85	5	.	.	PUNCT
biomedich-495	86	1	asterol	asterol	NOUN
biomedich-495	86	2	(	(	PUNCT
biomedich-495	86	3	c	c	NOUN
biomedich-495	86	4	)	)	PUNCT
biomedich-495	86	5	.	.	PUNCT
biomedich-495	87	1	butilin	butilin	NOUN
biomedich-495	87	2	(	(	PUNCT
biomedich-495	87	3	d	d	NOUN
biomedich-495	87	4	)	)	PUNCT
biomedich-495	87	5	.	.	PUNCT
biomedich-495	88	1	ellagic	ellagic	PROPN
biomedich-495	88	2	acid	acid	NOUN
biomedich-495	88	3	(	(	PUNCT
biomedich-495	88	4	e	e	NOUN
biomedich-495	88	5	)	)	PUNCT
biomedich-495	88	6	.	.	PUNCT
biomedich-495	89	1	gallic	gallic	NOUN
biomedich-495	89	2	acid	acid	NOUN
biomedich-495	89	3	(	(	PUNCT
biomedich-495	89	4	f	f	NOUN
biomedich-495	89	5	)	)	PUNCT
biomedich-495	89	6	.	.	PUNCT
biomedich-495	90	1	lupenone	lupenone	NOUN
biomedich-495	90	2	(	(	PUNCT
biomedich-495	90	3	g	g	NOUN
biomedich-495	90	4	)	)	PUNCT
biomedich-495	90	5	.	.	PUNCT
biomedich-495	91	1	lupeol	lupeol	NOUN
biomedich-495	91	2	(	(	PUNCT
biomedich-495	91	3	h	h	NOUN
biomedich-495	91	4	)	)	PUNCT
biomedich-495	91	5	.	.	PUNCT
biomedich-495	92	1	luteolin	luteolin	PROPN
biomedich-495	92	2	(	(	PUNCT
biomedich-495	92	3	i	i	NOUN
biomedich-495	92	4	)	)	PUNCT
biomedich-495	92	5	.	.	PUNCT
biomedich-495	93	1	quercetin	quercetin	NOUN
biomedich-495	93	2	(	(	PUNCT
biomedich-495	93	3	j	j	PROPN
biomedich-495	93	4	)	)	PUNCT
biomedich-495	93	5	.	.	PUNCT
biomedich-495	94	1	stigmasterol	stigmasterol	NOUN
biomedich-495	94	2	(	(	PUNCT
biomedich-495	94	3	k	k	NOUN
biomedich-495	94	4	)	)	PUNCT
biomedich-495	94	5	.	.	PUNCT
biomedich-495	95	1	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	95	2	that	that	PRON
biomedich-495	95	3	generated	generate	VERB
biomedich-495	95	4	using	use	VERB
biomedich-495	95	5	the	the	DET
biomedich-495	95	6	discovery	discovery	NOUN
biomedich-495	95	7	studio	studio	NOUN
biomedich-495	95	8	2021	2021	NUM
biomedich-495	95	9	client	client	NOUN
biomedich-495	95	10	.	.	PUNCT
biomedich-495	96	1	a	a	DET
biomedich-495	96	2	b	b	X
biomedich-495	96	3	c	c	NOUN
biomedich-495	96	4	d	d	X
biomedich-495	96	5	e	e	X
biomedich-495	96	6	f	f	PROPN
biomedich-495	96	7	g	g	PROPN
biomedich-495	97	1	h	h	NOUN
biomedich-495	98	1	i	i	INTJ
biomedich-495	98	2	j	j	PROPN
biomedich-495	99	1	k	k	NOUN
biomedich-495	99	2	210	210	NUM
biomedich-495	99	3	biology	biology	NOUN
biomedich-495	99	4	,	,	PUNCT
biomedich-495	99	5	medicine	medicine	NOUN
biomedich-495	99	6	,	,	PUNCT
biomedich-495	99	7	&	&	CCONJ
biomedich-495	99	8	natural	natural	ADJ
biomedich-495	99	9	product	product	NOUN
biomedich-495	99	10	chemistry	chemistry	NOUN
biomedich-495	99	11	13	13	NUM
biomedich-495	99	12	(	(	PUNCT
biomedich-495	99	13	1	1	NUM
biomedich-495	99	14	)	)	PUNCT
biomedich-495	99	15	,	,	PUNCT
biomedich-495	99	16	2024	2024	NUM
biomedich-495	99	17	:	:	PUNCT
biomedich-495	99	18	205	205	NUM
biomedich-495	99	19	-	-	SYM
biomedich-495	99	20	214	214	NUM
biomedich-495	99	21	figure	figure	NOUN
biomedich-495	99	22	4	4	NUM
biomedich-495	99	23	.	.	X
biomedich-495	99	24	diagram	diagram	NOUN
biomedich-495	99	25	showing	show	VERB
biomedich-495	99	26	the	the	DET
biomedich-495	99	27	binding	bind	VERB
biomedich-495	99	28	pockets	pocket	NOUN
biomedich-495	99	29	of	of	ADP
biomedich-495	99	30	amino	amino	NOUN
biomedich-495	99	31	acid	acid	NOUN
biomedich-495	99	32	residues	residue	NOUN
biomedich-495	99	33	that	that	PRON
biomedich-495	99	34	interact	interact	VERB
biomedich-495	99	35	with	with	ADP
biomedich-495	99	36	ligand	ligand	NOUN
biomedich-495	99	37	,	,	PUNCT
biomedich-495	99	38	(	(	PUNCT
biomedich-495	99	39	a	a	X
biomedich-495	99	40	)	)	PUNCT
biomedich-495	99	41	.	.	PUNCT
biomedich-495	100	1	apigenin	apigenin	PROPN
biomedich-495	100	2	(	(	PUNCT
biomedich-495	100	3	b	b	NOUN
biomedich-495	100	4	)	)	PUNCT
biomedich-495	100	5	.	.	PUNCT
biomedich-495	101	1	asterol	asterol	NOUN
biomedich-495	101	2	(	(	PUNCT
biomedich-495	101	3	c	c	NOUN
biomedich-495	101	4	)	)	PUNCT
biomedich-495	101	5	.	.	PUNCT
biomedich-495	102	1	butilin	butilin	NOUN
biomedich-495	102	2	(	(	PUNCT
biomedich-495	102	3	d	d	NOUN
biomedich-495	102	4	)	)	PUNCT
biomedich-495	102	5	.	.	PUNCT
biomedich-495	103	1	ellagic	ellagic	ADJ
biomedich-495	103	2	acid	acid	NOUN
biomedich-495	103	3	€	€	SYM
biomedich-495	103	4	.	.	PUNCT
biomedich-495	103	5	gallic	gallic	NOUN
biomedich-495	103	6	acid	acid	NOUN
biomedich-495	103	7	(	(	PUNCT
biomedich-495	103	8	f	f	NOUN
biomedich-495	103	9	)	)	PUNCT
biomedich-495	103	10	.	.	PUNCT
biomedich-495	104	1	lupenone	lupenone	NOUN
biomedich-495	104	2	(	(	PUNCT
biomedich-495	104	3	g	g	NOUN
biomedich-495	104	4	)	)	PUNCT
biomedich-495	104	5	.	.	PUNCT
biomedich-495	105	1	lupeol	lupeol	NOUN
biomedich-495	105	2	(	(	PUNCT
biomedich-495	105	3	h	h	NOUN
biomedich-495	105	4	)	)	PUNCT
biomedich-495	105	5	.	.	PUNCT
biomedich-495	106	1	luteolin	luteolin	PROPN
biomedich-495	106	2	(	(	PUNCT
biomedich-495	106	3	i	i	NOUN
biomedich-495	106	4	)	)	PUNCT
biomedich-495	106	5	.	.	PUNCT
biomedich-495	107	1	quercetin	quercetin	NOUN
biomedich-495	107	2	(	(	PUNCT
biomedich-495	107	3	j	j	PROPN
biomedich-495	107	4	)	)	PUNCT
biomedich-495	107	5	.	.	PUNCT
biomedich-495	108	1	stigmasterol	stigmasterol	NOUN
biomedich-495	108	2	(	(	PUNCT
biomedich-495	108	3	k	k	NOUN
biomedich-495	108	4	)	)	PUNCT
biomedich-495	108	5	.	.	PUNCT
biomedich-495	109	1	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	109	2	that	that	PRON
biomedich-495	109	3	generated	generate	VERB
biomedich-495	109	4	using	use	VERB
biomedich-495	109	5	the	the	DET
biomedich-495	109	6	discovery	discovery	NOUN
biomedich-495	109	7	studio	studio	NOUN
biomedich-495	109	8	2021	2021	NUM
biomedich-495	109	9	client	client	NOUN
biomedich-495	109	10	.	.	PUNCT
biomedich-495	110	1	a	a	DET
biomedich-495	110	2	b	b	X
biomedich-495	110	3	c	c	NOUN
biomedich-495	110	4	d	d	X
biomedich-495	110	5	e	e	X
biomedich-495	110	6	f	f	PROPN
biomedich-495	110	7	g	g	PROPN
biomedich-495	111	1	h	h	NOUN
biomedich-495	112	1	i	i	PRON
biomedich-495	112	2	j	j	PROPN
biomedich-495	113	1	k	k	PROPN
biomedich-495	113	2	perera	perera	PROPN
biomedich-495	113	3	&	&	CCONJ
biomedich-495	113	4	lawan	lawan	PROPN
biomedich-495	113	5	–	–	PUNCT
biomedich-495	113	6	antibacterial	antibacterial	ADJ
biomedich-495	113	7	potential	potential	NOUN
biomedich-495	113	8	of	of	ADP
biomedich-495	113	9	hygrophila	hygrophila	PROPN
biomedich-495	113	10	schulli	schulli	PROPN
biomedich-495	113	11	211	211	NUM
biomedich-495	113	12	table	table	NOUN
biomedich-495	113	13	2	2	NUM
biomedich-495	113	14	.	.	PUNCT
biomedich-495	113	15	predicted	predict	VERB
biomedich-495	113	16	physicochemical	physicochemical	ADJ
biomedich-495	113	17	properties	property	NOUN
biomedich-495	113	18	of	of	ADP
biomedich-495	113	19	studied	study	VERB
biomedich-495	113	20	secondary	secondary	ADJ
biomedich-495	113	21	meabolites	meabolite	NOUN
biomedich-495	113	22	;	;	PUNCT
biomedich-495	113	23	1molecular	1molecular	NUM
biomedich-495	113	24	weight	weight	NOUN
biomedich-495	113	25	(	(	PUNCT
biomedich-495	113	26	g	g	NOUN
biomedich-495	113	27	/	/	SYM
biomedich-495	113	28	mol	mol	NOUN
biomedich-495	113	29	)	)	PUNCT
biomedich-495	113	30	2num	2num	PROPN
biomedich-495	113	31	.	.	PUNCT
biomedich-495	113	32	heavy	heavy	ADJ
biomedich-495	113	33	atoms	atom	NOUN
biomedich-495	113	34	3num	3num	NUM
biomedich-495	113	35	.	.	PUNCT
biomedich-495	114	1	rotatable	rotatable	ADJ
biomedich-495	114	2	bonds	bond	NOUN
biomedich-495	114	3	4num	4num	NOUN
biomedich-495	114	4	.	.	PUNCT
biomedich-495	115	1	h	h	NOUN
biomedich-495	115	2	-	-	PUNCT
biomedich-495	115	3	bond	bond	NOUN
biomedich-495	115	4	acceptors	acceptor	NOUN
biomedich-495	116	1	5num	5num	NUM
biomedich-495	116	2	.	.	PUNCT
biomedich-495	117	1	h	h	NOUN
biomedich-495	117	2	-	-	PUNCT
biomedich-495	117	3	bond	bond	NOUN
biomedich-495	117	4	donors	donor	NOUN
biomedich-495	117	5	6	6	NUM
biomedich-495	117	6	-	-	PUNCT
biomedich-495	117	7	topological	topological	ADJ
biomedich-495	117	8	polar	polar	ADJ
biomedich-495	117	9	surface	surface	NOUN
biomedich-495	117	10	area(å²	area(å²	NOUN
biomedich-495	117	11	)	)	PUNCT
biomedich-495	117	12	7	7	NUM
biomedich-495	117	13	-	-	PUNCT
biomedich-495	117	14	lipinski	lipinski	PROPN
biomedich-495	117	15	’s	’s	PART
biomedich-495	117	16	rule	rule	NOUN
biomedich-495	117	17	of	of	ADP
biomedich-495	117	18	five	five	NUM
biomedich-495	117	19	8veber	8veber	NUM
biomedich-495	117	20	’s	’s	PART
biomedich-495	117	21	rule	rule	NOUN
biomedich-495	117	22	.	.	PUNCT
biomedich-495	118	1	compound	compound	NOUN
biomedich-495	118	2	mw1	mw1	PROPN
biomedich-495	118	3	n	n	CCONJ
biomedich-495	118	4	-	-	PUNCT
biomedich-495	118	5	nha2	nha2	PROPN
biomedich-495	118	6	n	n	CCONJ
biomedich-495	118	7	-	-	PUNCT
biomedich-495	118	8	rot3	rot3	NOUN
biomedich-495	118	9	n	n	CCONJ
biomedich-495	118	10	-	-	PUNCT
biomedich-495	118	11	hba4	hba4	PROPN
biomedich-495	118	12	n	n	CCONJ
biomedich-495	118	13	-	-	PUNCT
biomedich-495	118	14	hbd5	hbd5	NOUN
biomedich-495	118	15	tpsa6	tpsa6	NOUN
biomedich-495	118	16	lpi7	lpi7	PROPN
biomedich-495	118	17	ver8	ver8	PROPN
biomedich-495	118	18	ciprofloxacin	ciprofloxacin	VERB
biomedich-495	118	19	331.34	331.34	NUM
biomedich-495	118	20	24	24	NUM
biomedich-495	118	21	3	3	NUM
biomedich-495	118	22	5	5	NUM
biomedich-495	118	23	2	2	NUM
biomedich-495	118	24	74.57	74.57	NUM
biomedich-495	119	1	yes	yes	INTJ
biomedich-495	119	2	yes	yes	INTJ
biomedich-495	119	3	ellagic	ellagic	ADJ
biomedich-495	119	4	acid	acid	NOUN
biomedich-495	119	5	302.19	302.19	NUM
biomedich-495	119	6	22	22	NUM
biomedich-495	119	7	0	0	NUM
biomedich-495	119	8	8	8	NUM
biomedich-495	119	9	4	4	NUM
biomedich-495	119	10	141.34	141.34	NUM
biomedich-495	120	1	yes	yes	INTJ
biomedich-495	121	1	yes	yes	INTJ
biomedich-495	121	2	apigenin	apigenin	VERB
biomedich-495	121	3	270.24	270.24	NUM
biomedich-495	121	4	20	20	NUM
biomedich-495	121	5	1	1	NUM
biomedich-495	121	6	5	5	NUM
biomedich-495	121	7	3	3	NUM
biomedich-495	121	8	90.9	90.9	NUM
biomedich-495	122	1	yes	yes	INTJ
biomedich-495	122	2	yes	yes	INTJ
biomedich-495	122	3	quercetin	quercetin	NOUN
biomedich-495	122	4	302.24	302.24	NUM
biomedich-495	122	5	22	22	NUM
biomedich-495	122	6	1	1	NUM
biomedich-495	122	7	7	7	NUM
biomedich-495	122	8	5	5	NUM
biomedich-495	122	9	131.36	131.36	NUM
biomedich-495	123	1	yes	yes	INTJ
biomedich-495	124	1	yes	yes	INTJ
biomedich-495	124	2	luteolin	luteolin	PROPN
biomedich-495	124	3	286.24	286.24	NUM
biomedich-495	124	4	21	21	NUM
biomedich-495	124	5	1	1	NUM
biomedich-495	124	6	6	6	NUM
biomedich-495	124	7	4	4	NUM
biomedich-495	124	8	111.13	111.13	NUM
biomedich-495	125	1	yes	yes	INTJ
biomedich-495	125	2	yes	yes	INTJ
biomedich-495	125	3	gallic	gallic	NOUN
biomedich-495	125	4	acid	acid	NOUN
biomedich-495	125	5	170.12	170.12	NUM
biomedich-495	125	6	12	12	NUM
biomedich-495	125	7	1	1	NUM
biomedich-495	125	8	5	5	NUM
biomedich-495	125	9	4	4	NUM
biomedich-495	125	10	97.99	97.99	NUM
biomedich-495	125	11	yes	yes	INTJ
biomedich-495	125	12	yes	yes	INTJ
biomedich-495	125	13	lupeol	lupeol	VERB
biomedich-495	125	14	426.72	426.72	NUM
biomedich-495	125	15	31	31	NUM
biomedich-495	125	16	1	1	NUM
biomedich-495	125	17	1	1	NUM
biomedich-495	125	18	1	1	NUM
biomedich-495	125	19	135.14	135.14	NUM
biomedich-495	126	1	yes	yes	INTJ
biomedich-495	126	2	yes	yes	INTJ
biomedich-495	126	3	lupenone	lupenone	NOUN
biomedich-495	126	4	424.7	424.7	NUM
biomedich-495	126	5	31	31	NUM
biomedich-495	126	6	1	1	NUM
biomedich-495	126	7	1	1	NUM
biomedich-495	126	8	0	0	NUM
biomedich-495	126	9	134.18	134.18	NUM
biomedich-495	127	1	yes	yes	INTJ
biomedich-495	128	1	yes	yes	INTJ
biomedich-495	128	2	betulin	betulin	NOUN
biomedich-495	128	3	442.72	442.72	NUM
biomedich-495	128	4	32	32	NUM
biomedich-495	128	5	2	2	NUM
biomedich-495	128	6	2	2	NUM
biomedich-495	128	7	2	2	NUM
biomedich-495	128	8	40.46	40.46	NUM
biomedich-495	129	1	yes	yes	INTJ
biomedich-495	129	2	yes	yes	INTJ
biomedich-495	129	3	asterol	asterol	NOUN
biomedich-495	129	4	293.43	293.43	NUM
biomedich-495	129	5	9	9	NUM
biomedich-495	129	6	7	7	NUM
biomedich-495	129	7	3	3	NUM
biomedich-495	129	8	0	0	NUM
biomedich-495	129	9	56.84	56.84	NUM
biomedich-495	130	1	yes	yes	INTJ
biomedich-495	130	2	yes	yes	INTJ
biomedich-495	130	3	stigmasterol	stigmasterol	VERB
biomedich-495	130	4	412.69	412.69	NUM
biomedich-495	130	5	30	30	NUM
biomedich-495	130	6	5	5	NUM
biomedich-495	130	7	1	1	NUM
biomedich-495	130	8	1	1	NUM
biomedich-495	130	9	20.23	20.23	NUM
biomedich-495	131	1	yes	yes	INTJ
biomedich-495	131	2	yes	yes	INTJ
biomedich-495	131	3	table	table	NOUN
biomedich-495	131	4	3	3	NUM
biomedich-495	131	5	.	.	PUNCT
biomedich-495	131	6	predicted	predict	VERB
biomedich-495	131	7	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	131	8	properties	property	NOUN
biomedich-495	131	9	of	of	ADP
biomedich-495	131	10	studied	study	VERB
biomedich-495	131	11	secondary	secondary	ADJ
biomedich-495	131	12	metabolites	metabolite	NOUN
biomedich-495	131	13	;	;	PUNCT
biomedich-495	131	14	1	1	NUM
biomedich-495	131	15	-	-	PUNCT
biomedich-495	131	16	water	water	NOUN
biomedich-495	131	17	solubility	solubility	NOUN
biomedich-495	131	18	(	(	PUNCT
biomedich-495	131	19	log	log	PROPN
biomedich-495	131	20	mol	mol	PROPN
biomedich-495	131	21	/	/	SYM
biomedich-495	131	22	l	l	NOUN
biomedich-495	131	23	)	)	PUNCT
biomedich-495	131	24	2caco3	2caco3	NUM
biomedich-495	132	1	permeability	permeability	NOUN
biomedich-495	132	2	3	3	NUM
biomedich-495	132	3	-	-	PUNCT
biomedich-495	132	4	human	human	ADJ
biomedich-495	132	5	intestinal	intestinal	ADJ
biomedich-495	132	6	absorption	absorption	NOUN
biomedich-495	132	7	(	(	PUNCT
biomedich-495	132	8	%	%	NOUN
biomedich-495	132	9	absorbed	absorb	VERB
biomedich-495	132	10	)	)	PUNCT
biomedich-495	132	11	4skin	4skin	NUM
biomedich-495	132	12	permeability	permeability	NOUN
biomedich-495	132	13	(	(	PUNCT
biomedich-495	132	14	log	log	PROPN
biomedich-495	132	15	kp	kp	PROPN
biomedich-495	132	16	)	)	PUNCT
biomedich-495	132	17	5	5	NUM
biomedich-495	132	18	-	-	PUNCT
biomedich-495	132	19	p	p	NOUN
biomedich-495	132	20	-	-	PUNCT
biomedich-495	132	21	glycoprotein	glycoprotein	NOUN
biomedich-495	132	22	substrate	substrate	NOUN
biomedich-495	132	23	6	6	NUM
biomedich-495	132	24	p	p	NOUN
biomedich-495	132	25	-	-	PUNCT
biomedich-495	132	26	glycoprotein	glycoprotein	NOUN
biomedich-495	132	27	i	i	PRON
biomedich-495	132	28	inhibitor	inhibitor	VERB
biomedich-495	132	29	7	7	NUM
biomedich-495	132	30	-	-	PUNCT
biomedich-495	132	31	p	p	NOUN
biomedich-495	132	32	-	-	PUNCT
biomedich-495	132	33	glycoprotein	glycoprotein	NOUN
biomedich-495	132	34	ii	ii	NOUN
biomedich-495	132	35	8	8	NUM
biomedich-495	132	36	-	-	PUNCT
biomedich-495	132	37	vdss	vdss	ADV
biomedich-495	132	38	-	-	PUNCT
biomedich-495	132	39	human	human	NOUN
biomedich-495	132	40	(	(	PUNCT
biomedich-495	132	41	log	log	NOUN
biomedich-495	132	42	l	l	NOUN
biomedich-495	132	43	/	/	SYM
biomedich-495	132	44	kg	kg	NOUN
biomedich-495	132	45	)	)	PUNCT
biomedich-495	132	46	9	9	NUM
biomedich-495	132	47	-	-	PUNCT
biomedich-495	132	48	fraction	fraction	NOUN
biomedich-495	132	49	unbound	unbound	NOUN
biomedich-495	132	50	10	10	NUM
biomedich-495	132	51	-	-	PUNCT
biomedich-495	132	52	bbb	bbb	NOUN
biomedich-495	132	53	permeability	permeability	NOUN
biomedich-495	132	54	(	(	PUNCT
biomedich-495	132	55	log	log	NOUN
biomedich-495	132	56	bb	bb	NOUN
biomedich-495	132	57	)	)	PUNCT
biomedich-495	132	58	11	11	NUM
biomedich-495	132	59	-	-	PUNCT
biomedich-495	132	60	cns	cns	NOUN
biomedich-495	132	61	permeability	permeability	NOUN
biomedich-495	132	62	(	(	PUNCT
biomedich-495	132	63	log	log	NOUN
biomedich-495	132	64	ps	ps	PROPN
biomedich-495	132	65	)	)	PUNCT
biomedich-495	132	66	12	12	NUM
biomedich-495	132	67	–	–	PUNCT
biomedich-495	132	68	cyp2d6	cyp2d6	NOUN
biomedich-495	132	69	substrate	substrate	NOUN
biomedich-495	132	70	13	13	NUM
biomedich-495	132	71	-	-	PUNCT
biomedich-495	132	72	cyp3a4	cyp3a4	NOUN
biomedich-495	132	73	substrate	substrate	NOUN
biomedich-495	132	74	14cyp1a2	14cyp1a2	ADJ
biomedich-495	132	75	inhibitor	inhibitor	NOUN
biomedich-495	132	76	15cyp2c19	15cyp2c19	NUM
biomedich-495	132	77	inhibitor	inhibitor	NOUN
biomedich-495	132	78	16	16	NUM
biomedich-495	132	79	–	–	PUNCT
biomedich-495	132	80	cyp2c9	cyp2c9	NOUN
biomedich-495	132	81	inhibitor	inhibitor	NOUN
biomedich-495	132	82	17	17	NUM
biomedich-495	132	83	-cyp2d6	-cyp2d6	PROPN
biomedich-495	132	84	inhibitor	inhibitor	NOUN
biomedich-495	132	85	18	18	NUM
biomedich-495	132	86	-	-	PUNCT
biomedich-495	132	87	cyp3a4	cyp3a4	NOUN
biomedich-495	132	88	inhibitor	inhibitor	NOUN
biomedich-495	132	89	19	19	NUM
biomedich-495	132	90	-	-	PUNCT
biomedich-495	132	91	total	total	NOUN
biomedich-495	132	92	clearance	clearance	NOUN
biomedich-495	132	93	(	(	PUNCT
biomedich-495	132	94	log	log	VERB
biomedich-495	132	95	ml	ml	NOUN
biomedich-495	132	96	/	/	SYM
biomedich-495	132	97	min	min	NOUN
biomedich-495	132	98	/	/	SYM
biomedich-495	132	99	kg	kg	NOUN
biomedich-495	132	100	)	)	PUNCT
biomedich-495	132	101	20renal	20renal	ADJ
biomedich-495	132	102	oct2	oct2	NOUN
biomedich-495	132	103	substrate	substrate	NOUN
biomedich-495	132	104	21	21	NUM
biomedich-495	132	105	-ames	-ame	NOUN
biomedich-495	132	106	toxicity	toxicity	NOUN
biomedich-495	132	107	22	22	NUM
biomedich-495	132	108	–	–	PUNCT
biomedich-495	132	109	human	human	PROPN
biomedich-495	132	110	max	max	PROPN
biomedich-495	132	111	.	.	PROPN
biomedich-495	132	112	tolerated	tolerate	VERB
biomedich-495	132	113	dose	dose	PROPN
biomedich-495	132	114	(	(	PUNCT
biomedich-495	132	115	log	log	VERB
biomedich-495	132	116	mg	mg	PROPN
biomedich-495	132	117	/	/	SYM
biomedich-495	132	118	kg	kg	PROPN
biomedich-495	132	119	/	/	SYM
biomedich-495	132	120	day	day	NOUN
biomedich-495	132	121	)	)	PUNCT
biomedich-495	132	122	23herg	23herg	NUM
biomedich-495	133	1	i	i	PRON
biomedich-495	133	2	inhibitor	inhibitor	VERB
biomedich-495	133	3	24herg	24herg	NUM
biomedich-495	133	4	ii	ii	PROPN
biomedich-495	133	5	inhibitor	inhibitor	NOUN
biomedich-495	133	6	25oral	25oral	ADJ
biomedich-495	133	7	rat	rat	NOUN
biomedich-495	133	8	acute	acute	NOUN
biomedich-495	133	9	toxicity	toxicity	NOUN
biomedich-495	133	10	(	(	PUNCT
biomedich-495	133	11	ld50	ld50	PROPN
biomedich-495	133	12	mol	mol	PROPN
biomedich-495	133	13	/	/	SYM
biomedich-495	133	14	kg	kg	PROPN
biomedich-495	133	15	)	)	PUNCT
biomedich-495	133	16	26oral	26oral	NUM
biomedich-495	133	17	rat	rat	NOUN
biomedich-495	133	18	chronic	chronic	ADJ
biomedich-495	133	19	toxicity	toxicity	NOUN
biomedich-495	133	20	(	(	PUNCT
biomedich-495	133	21	loael	loael	ADJ
biomedich-495	133	22	log	log	NOUN
biomedich-495	133	23	mg	mg	PROPN
biomedich-495	133	24	/	/	SYM
biomedich-495	133	25	kg_bw	kg_bw	PROPN
biomedich-495	133	26	/	/	SYM
biomedich-495	133	27	day	day	NOUN
biomedich-495	133	28	)	)	PUNCT
biomedich-495	133	29	27hepatotoxicity	27hepatotoxicity	NUM
biomedich-495	133	30	28	28	NUM
biomedich-495	133	31	-	-	PUNCT
biomedich-495	133	32	skin	skin	NOUN
biomedich-495	133	33	sensitization	sensitization	NOUN
biomedich-495	133	34	29t.pyriformis	29t.pyriformis	ADP
biomedich-495	133	35	toxicity	toxicity	NOUN
biomedich-495	133	36	(	(	PUNCT
biomedich-495	133	37	log	log	VERB
biomedich-495	133	38	µg	µg	ADV
biomedich-495	133	39	/	/	SYM
biomedich-495	133	40	l	l	NOUN
biomedich-495	133	41	)	)	PUNCT
biomedich-495	133	42	30minnow	30minnow	NOUN
biomedich-495	133	43	toxicity	toxicity	NOUN
biomedich-495	133	44	(	(	PUNCT
biomedich-495	133	45	log	log	NOUN
biomedich-495	133	46	mm	mm	PROPN
biomedich-495	133	47	)	)	PUNCT
biomedich-495	133	48	.	.	PUNCT
biomedich-495	134	1	compound	compound	NOUN
biomedich-495	134	2	adsorption	adsorption	NOUN
biomedich-495	134	3	distribution	distribution	NOUN
biomedich-495	134	4	ws1	ws1	NOUN
biomedich-495	134	5	caco3p	caco3p	NOUN
biomedich-495	134	6	2	2	NUM
biomedich-495	134	7	ib(human)3	ib(human)3	NOUN
biomedich-495	134	8	sp4	sp4	NOUN
biomedich-495	134	9	p	p	NOUN
biomedich-495	134	10	-	-	PUNCT
biomedich-495	134	11	gly	gly	NOUN
biomedich-495	134	12	sub5	sub5	NOUN
biomedich-495	134	13	p	p	NOUN
biomedich-495	134	14	-	-	PUNCT
biomedich-495	134	15	gly	gly	NOUN
biomedich-495	135	1	i	i	PRON
biomedich-495	135	2	inb6	inb6	VERB
biomedich-495	135	3	p	p	NOUN
biomedich-495	135	4	-	-	PUNCT
biomedich-495	135	5	gly	gly	NOUN
biomedich-495	135	6	ii	ii	PROPN
biomedich-495	135	7	inb7	inb7	PROPN
biomedich-495	135	8	vdss	vdss	ADV
biomedich-495	135	9	(	(	PUNCT
biomedich-495	135	10	human)8	human)8	PROPN
biomedich-495	135	11	fu	fu	PROPN
biomedich-495	135	12	(	(	PUNCT
biomedich-495	135	13	human)9	human)9	VERB
biomedich-495	135	14	bbb	bbb	PROPN
biomedich-495	135	15	p10	p10	PROPN
biomedich-495	135	16	cns	cns	PROPN
biomedich-495	135	17	p11	p11	NOUN
biomedich-495	135	18	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	135	19	-2.897	-2.897	VERB
biomedich-495	135	20	0.492	0.492	NUM
biomedich-495	135	21	96.466	96.466	NUM
biomedich-495	135	22	-2.734	-2.734	NUM
biomedich-495	136	1	yes	yes	INTJ
biomedich-495	136	2	no	no	INTJ
biomedich-495	137	1	no	no	DET
biomedich-495	137	2	-0.17	-0.17	ADJ
biomedich-495	137	3	0.648	0.648	NUM
biomedich-495	137	4	-0.587	-0.587	PROPN
biomedich-495	137	5	-2.999	-2.999	X
biomedich-495	137	6	ellagic	ellagic	ADJ
biomedich-495	137	7	acid	acid	NOUN
biomedich-495	137	8	-3.181	-3.181	PUNCT
biomedich-495	137	9	0.335	0.335	NUM
biomedich-495	137	10	86.684	86.684	NUM
biomedich-495	137	11	-2.735	-2.735	NOUN
biomedich-495	138	1	yes	yes	INTJ
biomedich-495	138	2	no	no	INTJ
biomedich-495	138	3	no	no	DET
biomedich-495	138	4	0.375	0.375	NUM
biomedich-495	138	5	0.083	0.083	NUM
biomedich-495	138	6	-1.272	-1.272	NUM
biomedich-495	138	7	-3.533	-3.533	X
biomedich-495	138	8	apigenin	apigenin	ADJ
biomedich-495	138	9	-3.329	-3.329	NUM
biomedich-495	138	10	1.007	1.007	NUM
biomedich-495	138	11	93.25	93.25	NUM
biomedich-495	138	12	-2.735	-2.735	NOUN
biomedich-495	139	1	yes	yes	INTJ
biomedich-495	139	2	no	no	INTJ
biomedich-495	139	3	no	no	DET
biomedich-495	139	4	0.822	0.822	NUM
biomedich-495	139	5	0.147	0.147	NUM
biomedich-495	139	6	-0.734	-0.734	NUM
biomedich-495	139	7	-2.061	-2.061	NOUN
biomedich-495	140	1	quercetin	quercetin	NOUN
biomedich-495	140	2	-2.925	-2.925	SYM
biomedich-495	140	3	-0.229	-0.229	PUNCT
biomedich-495	140	4	77.207	77.207	NUM
biomedich-495	140	5	-2.735	-2.735	NOUN
biomedich-495	141	1	yes	yes	INTJ
biomedich-495	141	2	no	no	INTJ
biomedich-495	142	1	no	no	DET
biomedich-495	142	2	1.559	1.559	NUM
biomedich-495	142	3	0.206	0.206	NUM
biomedich-495	142	4	-1.098	-1.098	PUNCT
biomedich-495	142	5	-3.065	-3.065	NOUN
biomedich-495	142	6	luteolin	luteolin	PROPN
biomedich-495	142	7	-3.094	-3.094	PUNCT
biomedich-495	143	1	0.096	0.096	NUM
biomedich-495	143	2	81.13	81.13	NUM
biomedich-495	143	3	-2.735	-2.735	NOUN
biomedich-495	144	1	yes	yes	INTJ
biomedich-495	144	2	no	no	INTJ
biomedich-495	145	1	no	no	DET
biomedich-495	145	2	1.153	1.153	NUM
biomedich-495	145	3	0.168	0.168	NUM
biomedich-495	145	4	-0.907	-0.907	SYM
biomedich-495	145	5	-2.251	-2.251	SYM
biomedich-495	145	6	gallic	gallic	NOUN
biomedich-495	145	7	acid	acid	PROPN
biomedich-495	145	8	-2.56	-2.56	NUM
biomedich-495	145	9	-0.081	-0.081	PROPN
biomedich-495	145	10	43.374	43.374	NUM
biomedich-495	145	11	-2.735	-2.735	NOUN
biomedich-495	146	1	no	no	INTJ
biomedich-495	146	2	no	no	INTJ
biomedich-495	146	3	no	no	INTJ
biomedich-495	147	1	-1.855	-1.855	NUM
biomedich-495	147	2	0.617	0.617	NUM
biomedich-495	147	3	-1.102	-1.102	NUM
biomedich-495	147	4	-3.74	-3.74	NUM
biomedich-495	147	5	lupeol	lupeol	NOUN
biomedich-495	147	6	-5.861	-5.861	PUNCT
biomedich-495	147	7	1.226	1.226	NUM
biomedich-495	147	8	95.782	95.782	NUM
biomedich-495	147	9	-2.744	-2.744	NOUN
biomedich-495	148	1	no	no	INTJ
biomedich-495	148	2	yes	yes	INTJ
biomedich-495	149	1	yes	yes	INTJ
biomedich-495	150	1	0	0	NUM
biomedich-495	150	2	0	0	NUM
biomedich-495	150	3	0.726	0.726	NUM
biomedich-495	150	4	-1.714	-1.714	PUNCT
biomedich-495	150	5	lupenone	lupenone	NOUN
biomedich-495	150	6	-5.828	-5.828	NUM
biomedich-495	150	7	1.448	1.448	NUM
biomedich-495	150	8	98.467	98.467	NUM
biomedich-495	150	9	-2.567	-2.567	PUNCT
biomedich-495	150	10	no	no	INTJ
biomedich-495	151	1	yes	yes	INTJ
biomedich-495	151	2	yes	yes	INTJ
biomedich-495	152	1	-0.216	-0.216	NOUN
biomedich-495	152	2	0	0	NUM
biomedich-495	153	1	0.751	0.751	NUM
biomedich-495	153	2	-1.568	-1.568	NOUN
biomedich-495	153	3	betulin	betulin	NOUN
biomedich-495	153	4	-5.446	-5.446	NOUN
biomedich-495	153	5	1.191	1.191	NUM
biomedich-495	153	6	94.539	94.539	NUM
biomedich-495	153	7	-2.789	-2.789	NUM
biomedich-495	154	1	no	no	INTJ
biomedich-495	154	2	yes	yes	INTJ
biomedich-495	155	1	yes	yes	INTJ
biomedich-495	155	2	-0.177	-0.177	SYM
biomedich-495	155	3	0	0	NUM
biomedich-495	155	4	-0.295	-0.295	X
biomedich-495	155	5	-2.03	-2.03	PUNCT
biomedich-495	155	6	asterol	asterol	NOUN
biomedich-495	155	7	-2.855	-2.855	PUNCT
biomedich-495	155	8	1.655	1.655	NUM
biomedich-495	155	9	93.417	93.417	NUM
biomedich-495	155	10	-2.823	-2.823	NUM
biomedich-495	155	11	no	no	INTJ
biomedich-495	155	12	no	no	INTJ
biomedich-495	155	13	no	no	DET
biomedich-495	155	14	0.77	0.77	NUM
biomedich-495	155	15	0.327	0.327	NUM
biomedich-495	155	16	0.404	0.404	NUM
biomedich-495	155	17	-2.512	-2.512	NOUN
biomedich-495	155	18	stigmasterol	stigmasterol	NOUN
biomedich-495	155	19	-6.682	-6.682	ADP
biomedich-495	155	20	1.213	1.213	NUM
biomedich-495	155	21	94.97	94.97	NUM
biomedich-495	155	22	-2.783	-2.783	NOUN
biomedich-495	156	1	no	no	INTJ
biomedich-495	156	2	yes	yes	INTJ
biomedich-495	156	3	yes	yes	INTJ
biomedich-495	157	1	0.178	0.178	NUM
biomedich-495	157	2	0	0	NUM
biomedich-495	157	3	0.771	0.771	NUM
biomedich-495	157	4	-1.652	-1.652	PUNCT
biomedich-495	157	5	compound	compound	ADJ
biomedich-495	157	6	metabolism	metabolism	NOUN
biomedich-495	157	7	excretion	excretion	NOUN
biomedich-495	157	8	cyp2d6	cyp2d6	NOUN
biomedich-495	157	9	sub12	sub12	PROPN
biomedich-495	157	10	cyp3a4	cyp3a4	PROPN
biomedich-495	157	11	sub13	sub13	PROPN
biomedich-495	157	12	cyp1a2	cyp1a2	ADJ
biomedich-495	157	13	inb14	inb14	NOUN
biomedich-495	157	14	cyp2c19	cyp2c19	PROPN
biomedich-495	157	15	inb15	inb15	NOUN
biomedich-495	157	16	cyp2c9	cyp2c9	NOUN
biomedich-495	157	17	inb16	inb16	NOUN
biomedich-495	157	18	cyp2d6	cyp2d6	PROPN
biomedich-495	157	19	inb17	inb17	PROPN
biomedich-495	157	20	cyp3a4	cyp3a4	PROPN
biomedich-495	158	1	inb18	inb18	PROPN
biomedich-495	159	1	tc19	tc19	PROPN
biomedich-495	159	2	r	r	NOUN
biomedich-495	159	3	-	-	PUNCT
biomedich-495	159	4	oct2	oct2	NOUN
biomedich-495	159	5	sub20	sub20	NOUN
biomedich-495	159	6	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	160	1	no	no	INTJ
biomedich-495	160	2	no	no	INTJ
biomedich-495	160	3	no	no	INTJ
biomedich-495	160	4	no	no	INTJ
biomedich-495	160	5	no	no	INTJ
biomedich-495	160	6	no	no	INTJ
biomedich-495	160	7	no	no	INTJ
biomedich-495	160	8	0.633	0.633	NUM
biomedich-495	161	1	no	no	DET
biomedich-495	161	2	ellagic	ellagic	ADJ
biomedich-495	161	3	acid	acid	NOUN
biomedich-495	162	1	no	no	INTJ
biomedich-495	162	2	no	no	INTJ
biomedich-495	163	1	yes	yes	INTJ
biomedich-495	164	1	no	no	INTJ
biomedich-495	164	2	no	no	INTJ
biomedich-495	165	1	no	no	INTJ
biomedich-495	165	2	no	no	DET
biomedich-495	165	3	0.537	0.537	NUM
biomedich-495	165	4	no	no	INTJ
biomedich-495	165	5	apigenin	apigenin	ADV
biomedich-495	166	1	no	no	INTJ
biomedich-495	167	1	no	no	INTJ
biomedich-495	168	1	yes	yes	INTJ
biomedich-495	169	1	yes	yes	INTJ
biomedich-495	170	1	no	no	INTJ
biomedich-495	171	1	no	no	INTJ
biomedich-495	171	2	no	no	INTJ
biomedich-495	171	3	0.566	0.566	NUM
biomedich-495	171	4	no	no	DET
biomedich-495	171	5	quercetin	quercetin	NOUN
biomedich-495	172	1	no	no	INTJ
biomedich-495	172	2	no	no	INTJ
biomedich-495	173	1	yes	yes	INTJ
biomedich-495	174	1	no	no	INTJ
biomedich-495	174	2	no	no	INTJ
biomedich-495	175	1	no	no	INTJ
biomedich-495	175	2	no	no	DET
biomedich-495	175	3	0.407	0.407	NUM
biomedich-495	175	4	no	no	INTJ
biomedich-495	175	5	luteolin	luteolin	INTJ
biomedich-495	176	1	no	no	INTJ
biomedich-495	177	1	no	no	INTJ
biomedich-495	178	1	yes	yes	INTJ
biomedich-495	179	1	no	no	INTJ
biomedich-495	180	1	yes	yes	INTJ
biomedich-495	180	2	no	no	INTJ
biomedich-495	180	3	no	no	DET
biomedich-495	180	4	0.495	0.495	NUM
biomedich-495	180	5	no	no	DET
biomedich-495	180	6	gallic	gallic	NOUN
biomedich-495	180	7	acid	acid	NOUN
biomedich-495	181	1	no	no	INTJ
biomedich-495	181	2	no	no	INTJ
biomedich-495	181	3	no	no	INTJ
biomedich-495	181	4	no	no	INTJ
biomedich-495	181	5	no	no	INTJ
biomedich-495	181	6	no	no	INTJ
biomedich-495	181	7	no	no	DET
biomedich-495	181	8	0.518	0.518	NUM
biomedich-495	181	9	no	no	DET
biomedich-495	181	10	lupeol	lupeol	NOUN
biomedich-495	182	1	no	no	INTJ
biomedich-495	182	2	yes	yes	INTJ
biomedich-495	183	1	no	no	INTJ
biomedich-495	183	2	no	no	INTJ
biomedich-495	184	1	no	no	INTJ
biomedich-495	184	2	no	no	INTJ
biomedich-495	184	3	no	no	INTJ
biomedich-495	184	4	0.153	0.153	NUM
biomedich-495	184	5	no	no	DET
biomedich-495	184	6	lupenone	lupenone	NOUN
biomedich-495	185	1	no	no	INTJ
biomedich-495	185	2	yes	yes	INTJ
biomedich-495	186	1	no	no	INTJ
biomedich-495	186	2	no	no	INTJ
biomedich-495	187	1	no	no	INTJ
biomedich-495	187	2	no	no	INTJ
biomedich-495	187	3	no	no	DET
biomedich-495	187	4	0.102	0.102	NUM
biomedich-495	188	1	no	no	DET
biomedich-495	188	2	betulin	betulin	NOUN
biomedich-495	189	1	no	no	INTJ
biomedich-495	190	1	yes	yes	INTJ
biomedich-495	190	2	no	no	INTJ
biomedich-495	191	1	no	no	INTJ
biomedich-495	191	2	no	no	INTJ
biomedich-495	192	1	no	no	INTJ
biomedich-495	192	2	no	no	DET
biomedich-495	192	3	0.236	0.236	NUM
biomedich-495	192	4	no	no	DET
biomedich-495	192	5	asterol	asterol	NOUN
biomedich-495	193	1	no	no	INTJ
biomedich-495	193	2	yes	yes	INTJ
biomedich-495	194	1	yes	yes	INTJ
biomedich-495	195	1	no	no	INTJ
biomedich-495	196	1	no	no	INTJ
biomedich-495	196	2	yes	yes	INTJ
biomedich-495	196	3	no	no	DET
biomedich-495	196	4	0.878	0.878	NUM
biomedich-495	196	5	no	no	DET
biomedich-495	196	6	stigmasterol	stigmasterol	NOUN
biomedich-495	197	1	no	no	INTJ
biomedich-495	197	2	yes	yes	INTJ
biomedich-495	198	1	no	no	INTJ
biomedich-495	198	2	no	no	INTJ
biomedich-495	199	1	no	no	INTJ
biomedich-495	199	2	no	no	INTJ
biomedich-495	199	3	no	no	INTJ
biomedich-495	199	4	0.618	0.618	NUM
biomedich-495	199	5	no	no	DET
biomedich-495	199	6	compound	compound	NOUN
biomedich-495	199	7	toxicity	toxicity	NOUN
biomedich-495	199	8	ames	ame	NOUN
biomedich-495	199	9	t21	t21	PROPN
biomedich-495	199	10	m.t.d	m.t.d	VERB
biomedich-495	199	11	(	(	PUNCT
biomedich-495	199	12	human)22	human)22	PROPN
biomedich-495	199	13	herg	herg	PROPN
biomedich-495	200	1	i	i	PRON
biomedich-495	200	2	inb23	inb23	PROPN
biomedich-495	200	3	herg	herg	PROPN
biomedich-495	200	4	ii	ii	PROPN
biomedich-495	200	5	inb24	inb24	PROPN
biomedich-495	200	6	orat	orat	NOUN
biomedich-495	200	7	(	(	PUNCT
biomedich-495	200	8	ld50)25	ld50)25	PROPN
biomedich-495	200	9	orct	orct	PROPN
biomedich-495	200	10	(	(	PUNCT
biomedich-495	200	11	loael)26	loael)26	PROPN
biomedich-495	200	12	hepatptox.27	hepatptox.27	PROPN
biomedich-495	200	13	skin	skin	PROPN
biomedich-495	200	14	s28	s28	PROPN
biomedich-495	200	15	t.pyriformis	t.pyriformis	PROPN
biomedich-495	200	16	t29	t29	PROPN
biomedich-495	200	17	min	min	PROPN
biomedich-495	200	18	t30	t30	PROPN
biomedich-495	200	19	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	200	20	no	no	DET
biomedich-495	200	21	0.924	0.924	NUM
biomedich-495	200	22	no	no	NOUN
biomedich-495	200	23	no	no	DET
biomedich-495	200	24	2.891	2.891	NUM
biomedich-495	200	25	1.036	1.036	NUM
biomedich-495	200	26	yes	yes	INTJ
biomedich-495	200	27	no	no	DET
biomedich-495	200	28	0.286	0.286	NUM
biomedich-495	200	29	1.194	1.194	NUM
biomedich-495	200	30	ellagic	ellagic	ADJ
biomedich-495	200	31	acid	acid	NOUN
biomedich-495	200	32	no	no	DET
biomedich-495	200	33	0.476	0.476	NUM
biomedich-495	200	34	no	no	NOUN
biomedich-495	200	35	no	no	DET
biomedich-495	200	36	2.399	2.399	NUM
biomedich-495	200	37	2.698	2.698	NUM
biomedich-495	200	38	no	no	INTJ
biomedich-495	200	39	no	no	DET
biomedich-495	200	40	0.295	0.295	NUM
biomedich-495	200	41	2.11	2.11	NUM
biomedich-495	200	42	apigenin	apigenin	NOUN
biomedich-495	200	43	no	no	DET
biomedich-495	200	44	0.328	0.328	NUM
biomedich-495	200	45	no	no	INTJ
biomedich-495	200	46	no	no	DET
biomedich-495	200	47	2.45	2.45	NUM
biomedich-495	200	48	2.298	2.298	NUM
biomedich-495	200	49	no	no	INTJ
biomedich-495	200	50	no	no	DET
biomedich-495	200	51	0.38	0.38	NUM
biomedich-495	200	52	2.432	2.432	NUM
biomedich-495	200	53	quercetin	quercetin	NOUN
biomedich-495	200	54	no	no	DET
biomedich-495	200	55	2.471	2.471	NUM
biomedich-495	200	56	no	no	INTJ
biomedich-495	200	57	no	no	DET
biomedich-495	200	58	2.471	2.471	NUM
biomedich-495	200	59	2.612	2.612	NUM
biomedich-495	200	60	no	no	NOUN
biomedich-495	200	61	no	no	ADV
biomedich-495	200	62	0.288	0.288	NUM
biomedich-495	200	63	3.721	3.721	NUM
biomedich-495	200	64	luteolin	luteolin	PROPN
biomedich-495	201	1	no	no	DET
biomedich-495	201	2	0.499	0.499	NUM
biomedich-495	201	3	no	no	INTJ
biomedich-495	201	4	no	no	DET
biomedich-495	201	5	2.455	2.455	NUM
biomedich-495	201	6	2.409	2.409	NUM
biomedich-495	201	7	no	no	DET
biomedich-495	201	8	no	no	DET
biomedich-495	201	9	0.326	0.326	NUM
biomedich-495	201	10	3.169	3.169	NUM
biomedich-495	201	11	gallic	gallic	NOUN
biomedich-495	201	12	acid	acid	NOUN
biomedich-495	202	1	no	no	DET
biomedich-495	202	2	0.7	0.7	NUM
biomedich-495	202	3	no	no	INTJ
biomedich-495	202	4	no	no	DET
biomedich-495	202	5	2.218	2.218	NUM
biomedich-495	202	6	3.06	3.06	NUM
biomedich-495	202	7	no	no	PRON
biomedich-495	202	8	no	no	DET
biomedich-495	202	9	0.285	0.285	NUM
biomedich-495	202	10	3.188	3.188	NUM
biomedich-495	202	11	lupeol	lupeol	NOUN
biomedich-495	203	1	no	no	PRON
biomedich-495	203	2	-0.502	-0.502	INTJ
biomedich-495	204	1	no	no	INTJ
biomedich-495	204	2	yes	yes	INTJ
biomedich-495	204	3	2.563	2.563	NUM
biomedich-495	204	4	0.89	0.89	NUM
biomedich-495	205	1	no	no	INTJ
biomedich-495	206	1	no	no	DET
biomedich-495	206	2	0.316	0.316	NUM
biomedich-495	206	3	-1.696	-1.696	NOUN
biomedich-495	206	4	lupenone	lupenone	NOUN
biomedich-495	206	5	no	no	DET
biomedich-495	206	6	0.008	0.008	NUM
biomedich-495	206	7	no	no	INTJ
biomedich-495	206	8	yes	yes	ADV
biomedich-495	206	9	2.556	2.556	NUM
biomedich-495	206	10	0.831	0.831	NUM
biomedich-495	206	11	no	no	INTJ
biomedich-495	206	12	no	no	DET
biomedich-495	206	13	0.315	0.315	NUM
biomedich-495	206	14	-1.777	-1.777	PROPN
biomedich-495	206	15	betulin	betulin	NOUN
biomedich-495	207	1	no	no	PRON
biomedich-495	207	2	-0.794	-0.794	INTJ
biomedich-495	208	1	no	no	INTJ
biomedich-495	208	2	yes	yes	INTJ
biomedich-495	209	1	2.699	2.699	NUM
biomedich-495	209	2	2.172	2.172	NUM
biomedich-495	209	3	yes	yes	INTJ
biomedich-495	210	1	no	no	DET
biomedich-495	210	2	0.315	0.315	NUM
biomedich-495	210	3	-1.118	-1.118	NUM
biomedich-495	210	4	asterol	asterol	NOUN
biomedich-495	210	5	no	no	DET
biomedich-495	210	6	0.103	0.103	NUM
biomedich-495	210	7	no	no	NOUN
biomedich-495	210	8	no	no	DET
biomedich-495	210	9	2.991	2.991	NUM
biomedich-495	210	10	1.235	1.235	NUM
biomedich-495	210	11	yes	yes	INTJ
biomedich-495	210	12	no	no	DET
biomedich-495	210	13	1.173	1.173	NUM
biomedich-495	210	14	0.956	0.956	NUM
biomedich-495	210	15	stigmasterol	stigmasterol	NOUN
biomedich-495	210	16	no	no	PRON
biomedich-495	210	17	-0.664	-0.664	NOUN
biomedich-495	211	1	no	no	INTJ
biomedich-495	211	2	yes	yes	INTJ
biomedich-495	212	1	2.54	2.54	NUM
biomedich-495	212	2	0.872	0.872	NUM
biomedich-495	212	3	no	no	DET
biomedich-495	212	4	no	no	DET
biomedich-495	212	5	0.433	0.433	NUM
biomedich-495	212	6	-1.675	-1.675	SYM
biomedich-495	212	7	212	212	NUM
biomedich-495	212	8	biology	biology	NOUN
biomedich-495	212	9	,	,	PUNCT
biomedich-495	212	10	medicine	medicine	NOUN
biomedich-495	212	11	,	,	PUNCT
biomedich-495	212	12	&	&	CCONJ
biomedich-495	212	13	natural	natural	ADJ
biomedich-495	212	14	product	product	NOUN
biomedich-495	212	15	chemistry	chemistry	NOUN
biomedich-495	212	16	13	13	NUM
biomedich-495	212	17	(	(	PUNCT
biomedich-495	212	18	1	1	NUM
biomedich-495	212	19	)	)	PUNCT
biomedich-495	212	20	,	,	PUNCT
biomedich-495	212	21	2024	2024	NUM
biomedich-495	212	22	:	:	PUNCT
biomedich-495	212	23	205	205	NUM
biomedich-495	212	24	-	-	SYM
biomedich-495	212	25	214	214	NUM
biomedich-495	212	26	discussion	discussion	NOUN
biomedich-495	212	27	in	in	ADP
biomedich-495	212	28	this	this	DET
biomedich-495	212	29	study	study	NOUN
biomedich-495	212	30	,	,	PUNCT
biomedich-495	212	31	ciprofloxacin	ciprofloxacin	PROPN
biomedich-495	212	32	was	be	AUX
biomedich-495	212	33	used	use	VERB
biomedich-495	212	34	as	as	ADP
biomedich-495	212	35	the	the	DET
biomedich-495	212	36	reference	reference	NOUN
biomedich-495	212	37	compound	compound	NOUN
biomedich-495	212	38	,	,	PUNCT
biomedich-495	212	39	the	the	DET
biomedich-495	212	40	known	known	ADJ
biomedich-495	212	41	bacterial	bacterial	ADJ
biomedich-495	212	42	topoisomerase	topoisomerase	NOUN
biomedich-495	212	43	iv	iv	NUM
biomedich-495	212	44	inhibitor	inhibitor	NOUN
biomedich-495	212	45	,	,	PUNCT
biomedich-495	212	46	to	to	PART
biomedich-495	212	47	compare	compare	VERB
biomedich-495	212	48	the	the	DET
biomedich-495	212	49	binding	bind	VERB
biomedich-495	212	50	energies	energy	NOUN
biomedich-495	212	51	and	and	CCONJ
biomedich-495	212	52	inhibition	inhibition	VERB
biomedich-495	212	53	constants	constant	NOUN
biomedich-495	212	54	with	with	ADP
biomedich-495	212	55	the	the	DET
biomedich-495	212	56	examined	examine	VERB
biomedich-495	212	57	secondary	secondary	ADJ
biomedich-495	212	58	metabolites	metabolite	NOUN
biomedich-495	212	59	.	.	PUNCT
biomedich-495	213	1	the	the	DET
biomedich-495	213	2	concentration	concentration	NOUN
biomedich-495	213	3	needed	need	VERB
biomedich-495	213	4	to	to	PART
biomedich-495	213	5	cause	cause	VERB
biomedich-495	213	6	half	half	NOUN
biomedich-495	213	7	of	of	ADP
biomedich-495	213	8	the	the	DET
biomedich-495	213	9	maximum	maximum	ADJ
biomedich-495	213	10	inhibition	inhibition	NOUN
biomedich-495	213	11	is	be	AUX
biomedich-495	213	12	known	know	VERB
biomedich-495	213	13	as	as	ADP
biomedich-495	213	14	the	the	DET
biomedich-495	213	15	inhibition	inhibition	NOUN
biomedich-495	213	16	constant	constant	ADJ
biomedich-495	213	17	(	(	PUNCT
biomedich-495	213	18	ki	ki	PROPN
biomedich-495	213	19	)	)	PUNCT
biomedich-495	213	20	,	,	PUNCT
biomedich-495	213	21	which	which	PRON
biomedich-495	213	22	serves	serve	VERB
biomedich-495	213	23	as	as	ADP
biomedich-495	213	24	a	a	DET
biomedich-495	213	25	measure	measure	NOUN
biomedich-495	213	26	of	of	ADP
biomedich-495	213	27	an	an	DET
biomedich-495	213	28	inhibitor	inhibitor	NOUN
biomedich-495	213	29	's	's	PART
biomedich-495	213	30	potency	potency	NOUN
biomedich-495	213	31	.	.	PUNCT
biomedich-495	214	1	when	when	SCONJ
biomedich-495	214	2	comparing	compare	VERB
biomedich-495	214	3	the	the	DET
biomedich-495	214	4	binding	bind	VERB
biomedich-495	214	5	energies	energy	NOUN
biomedich-495	214	6	of	of	ADP
biomedich-495	214	7	docked	docked	ADJ
biomedich-495	214	8	ligands	ligand	NOUN
biomedich-495	214	9	and	and	CCONJ
biomedich-495	214	10	reference	reference	NOUN
biomedich-495	214	11	drugs	drug	NOUN
biomedich-495	214	12	,	,	PUNCT
biomedich-495	214	13	apigenin	apigenin	PROPN
biomedich-495	214	14	(	(	PUNCT
biomedich-495	214	15	-4.65	-4.65	NOUN
biomedich-495	214	16	kcal	kcal	PROPN
biomedich-495	214	17	/	/	SYM
biomedich-495	214	18	mol	mol	NOUN
biomedich-495	214	19	)	)	PUNCT
biomedich-495	214	20	,	,	PUNCT
biomedich-495	214	21	luteolin	luteolin	PROPN
biomedich-495	214	22	(	(	PUNCT
biomedich-495	214	23	4.58	4.58	NUM
biomedich-495	214	24	kcal	kcal	NOUN
biomedich-495	214	25	/	/	SYM
biomedich-495	214	26	mol	mol	NOUN
biomedich-495	214	27	)	)	PUNCT
biomedich-495	214	28	,	,	PUNCT
biomedich-495	214	29	asterol	asterol	NOUN
biomedich-495	214	30	(	(	PUNCT
biomedich-495	214	31	-4.40	-4.40	PROPN
biomedich-495	214	32	kcal	kcal	PROPN
biomedich-495	214	33	/	/	SYM
biomedich-495	214	34	mol	mol	NOUN
biomedich-495	214	35	)	)	PUNCT
biomedich-495	214	36	,	,	PUNCT
biomedich-495	214	37	stigmasterol	stigmasterol	NOUN
biomedich-495	214	38	(	(	PUNCT
biomedich-495	214	39	5.23	5.23	NUM
biomedich-495	214	40	kcal	kcal	NOUN
biomedich-495	214	41	/	/	SYM
biomedich-495	214	42	mol	mol	NOUN
biomedich-495	214	43	)	)	PUNCT
biomedich-495	214	44	,	,	PUNCT
biomedich-495	214	45	betulin	betulin	NOUN
biomedich-495	214	46	(	(	PUNCT
biomedich-495	214	47	-5.40	-5.40	PROPN
biomedich-495	214	48	kcal	kcal	PROPN
biomedich-495	214	49	/	/	SYM
biomedich-495	214	50	mol	mol	NOUN
biomedich-495	214	51	)	)	PUNCT
biomedich-495	214	52	,	,	PUNCT
biomedich-495	214	53	lupeol	lupeol	NOUN
biomedich-495	214	54	(	(	PUNCT
biomedich-495	214	55	-6.05	-6.05	NOUN
biomedich-495	214	56	kcal	kcal	NOUN
biomedich-495	214	57	/	/	SYM
biomedich-495	214	58	mol	mol	NOUN
biomedich-495	214	59	)	)	PUNCT
biomedich-495	214	60	,	,	PUNCT
biomedich-495	214	61	and	and	CCONJ
biomedich-495	214	62	lupenone	lupenone	NOUN
biomedich-495	214	63	(	(	PUNCT
biomedich-495	214	64	-6.15	-6.15	NOUN
biomedich-495	214	65	kcal	kcal	NOUN
biomedich-495	214	66	/	/	SYM
biomedich-495	214	67	mol	mol	NOUN
biomedich-495	214	68	)	)	PUNCT
biomedich-495	214	69	exhibit	exhibit	VERB
biomedich-495	214	70	even	even	ADV
biomedich-495	214	71	better	well	ADV
biomedich-495	214	72	binding	bind	VERB
biomedich-495	214	73	affinity	affinity	NOUN
biomedich-495	214	74	to	to	ADP
biomedich-495	214	75	the	the	DET
biomedich-495	214	76	target	target	NOUN
biomedich-495	214	77	protein	protein	NOUN
biomedich-495	214	78	than	than	ADP
biomedich-495	214	79	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	214	80	(	(	PUNCT
biomedich-495	214	81	4.21	4.21	NUM
biomedich-495	214	82	kcal	kcal	NOUN
biomedich-495	214	83	/	/	SYM
biomedich-495	214	84	mol	mol	NOUN
biomedich-495	214	85	)	)	PUNCT
biomedich-495	214	86	.	.	PUNCT
biomedich-495	215	1	(	(	PUNCT
biomedich-495	215	2	table	table	NOUN
biomedich-495	215	3	01	01	NUM
biomedich-495	215	4	)	)	PUNCT
biomedich-495	215	5	also	also	ADV
biomedich-495	215	6	,	,	PUNCT
biomedich-495	215	7	those	those	DET
biomedich-495	215	8	two	two	NUM
biomedich-495	215	9	compounds	compound	NOUN
biomedich-495	215	10	show	show	VERB
biomedich-495	215	11	lower	low	ADJ
biomedich-495	215	12	ki	ki	PROPN
biomedich-495	215	13	values	value	NOUN
biomedich-495	215	14	than	than	ADP
biomedich-495	215	15	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	215	16	,	,	PUNCT
biomedich-495	215	17	indicating	indicate	VERB
biomedich-495	215	18	better	well	ADJ
biomedich-495	215	19	potency	potency	NOUN
biomedich-495	215	20	towards	towards	ADP
biomedich-495	215	21	the	the	DET
biomedich-495	215	22	topoisomerase	topoisomerase	NOUN
biomedich-495	215	23	iv	iv	NUM
biomedich-495	215	24	inhibition	inhibition	NOUN
biomedich-495	215	25	.	.	PUNCT
biomedich-495	216	1	it	it	PRON
biomedich-495	216	2	was	be	AUX
biomedich-495	216	3	evident	evident	ADJ
biomedich-495	216	4	that	that	SCONJ
biomedich-495	216	5	the	the	DET
biomedich-495	216	6	topranked	topranke	VERB
biomedich-495	216	7	phytochemical	phytochemical	ADJ
biomedich-495	216	8	structures	structure	NOUN
biomedich-495	216	9	'	'	PART
biomedich-495	216	10	hydroxyl	hydroxyl	NOUN
biomedich-495	216	11	groups	group	NOUN
biomedich-495	216	12	play	play	VERB
biomedich-495	216	13	a	a	DET
biomedich-495	216	14	substantial	substantial	ADJ
biomedich-495	216	15	role	role	NOUN
biomedich-495	216	16	in	in	ADP
biomedich-495	216	17	the	the	DET
biomedich-495	216	18	establishment	establishment	NOUN
biomedich-495	216	19	of	of	ADP
biomedich-495	216	20	potent	potent	ADJ
biomedich-495	216	21	hydrogen	hydrogen	NOUN
biomedich-495	216	22	bonds	bond	NOUN
biomedich-495	216	23	with	with	ADP
biomedich-495	216	24	amino	amino	NOUN
biomedich-495	216	25	acid	acid	NOUN
biomedich-495	216	26	residues	residue	NOUN
biomedich-495	216	27	in	in	ADP
biomedich-495	216	28	the	the	DET
biomedich-495	216	29	binding	bind	VERB
biomedich-495	216	30	pockets	pocket	NOUN
biomedich-495	216	31	.	.	PUNCT
biomedich-495	217	1	(	(	PUNCT
biomedich-495	217	2	figure	figure	NOUN
biomedich-495	217	3	02	02	NUM
biomedich-495	217	4	)	)	PUNCT
biomedich-495	217	5	the	the	DET
biomedich-495	217	6	in	in	ADP
biomedich-495	217	7	-	-	PUNCT
biomedich-495	217	8	silico	silico	NOUN
biomedich-495	217	9	analysis	analysis	NOUN
biomedich-495	217	10	presented	present	VERB
biomedich-495	217	11	in	in	ADP
biomedich-495	217	12	the	the	DET
biomedich-495	217	13	uploaded	upload	VERB
biomedich-495	217	14	document	document	NOUN
biomedich-495	217	15	explores	explore	VERB
biomedich-495	217	16	the	the	DET
biomedich-495	217	17	potential	potential	ADJ
biomedich-495	217	18	structural	structural	ADJ
biomedich-495	217	19	inhibition	inhibition	NOUN
biomedich-495	217	20	of	of	ADP
biomedich-495	217	21	bacterial	bacterial	ADJ
biomedich-495	217	22	dna	dna	NOUN
biomedich-495	217	23	topoisomerase	topoisomerase	NOUN
biomedich-495	217	24	iv	iv	NUM
biomedich-495	217	25	by	by	ADP
biomedich-495	217	26	major	major	ADJ
biomedich-495	217	27	secondary	secondary	ADJ
biomedich-495	217	28	metabolites	metabolite	NOUN
biomedich-495	217	29	extracted	extract	VERB
biomedich-495	217	30	from	from	ADP
biomedich-495	217	31	the	the	DET
biomedich-495	217	32	medicinal	medicinal	ADJ
biomedich-495	217	33	plant	plant	NOUN
biomedich-495	217	34	hygrophila	hygrophila	PROPN
biomedich-495	217	35	schulli	schulli	PROPN
biomedich-495	217	36	.	.	PUNCT
biomedich-495	218	1	the	the	DET
biomedich-495	218	2	study	study	NOUN
biomedich-495	218	3	utilized	utilize	VERB
biomedich-495	218	4	computational	computational	ADJ
biomedich-495	218	5	approaches	approach	NOUN
biomedich-495	218	6	,	,	PUNCT
biomedich-495	218	7	including	include	VERB
biomedich-495	218	8	molecular	molecular	ADJ
biomedich-495	218	9	docking	docking	NOUN
biomedich-495	218	10	simulations	simulation	NOUN
biomedich-495	218	11	and	and	CCONJ
biomedich-495	218	12	molecular	molecular	ADJ
biomedich-495	218	13	dynamics	dynamic	NOUN
biomedich-495	218	14	simulations	simulation	NOUN
biomedich-495	218	15	,	,	PUNCT
biomedich-495	218	16	to	to	PART
biomedich-495	218	17	investigate	investigate	VERB
biomedich-495	218	18	the	the	DET
biomedich-495	218	19	binding	bind	VERB
biomedich-495	218	20	affinities	affinity	NOUN
biomedich-495	218	21	,	,	PUNCT
biomedich-495	218	22	interactions	interaction	NOUN
biomedich-495	218	23	,	,	PUNCT
biomedich-495	218	24	and	and	CCONJ
biomedich-495	218	25	dynamic	dynamic	ADJ
biomedich-495	218	26	behavior	behavior	NOUN
biomedich-495	218	27	of	of	ADP
biomedich-495	218	28	the	the	DET
biomedich-495	218	29	identified	identify	VERB
biomedich-495	218	30	secondary	secondary	ADJ
biomedich-495	218	31	metabolites	metabolite	NOUN
biomedich-495	218	32	from	from	ADP
biomedich-495	218	33	hygrophila	hygrophila	PROPN
biomedich-495	218	34	schulli	schulli	PROPN
biomedich-495	218	35	with	with	ADP
biomedich-495	218	36	the	the	DET
biomedich-495	218	37	target	target	NOUN
biomedich-495	218	38	bacterial	bacterial	ADJ
biomedich-495	218	39	dna	dna	NOUN
biomedich-495	218	40	topoisomerase	topoisomerase	NOUN
biomedich-495	218	41	iv	iv	NOUN
biomedich-495	218	42	.	.	PUNCT
biomedich-495	219	1	the	the	DET
biomedich-495	219	2	results	result	NOUN
biomedich-495	219	3	of	of	ADP
biomedich-495	219	4	the	the	DET
biomedich-495	219	5	molecular	molecular	ADJ
biomedich-495	219	6	docking	docking	NOUN
biomedich-495	219	7	simulations	simulation	NOUN
biomedich-495	219	8	revealed	reveal	VERB
biomedich-495	219	9	promising	promising	ADJ
biomedich-495	219	10	interactions	interaction	NOUN
biomedich-495	219	11	,	,	PUNCT
biomedich-495	219	12	suggesting	suggest	VERB
biomedich-495	219	13	a	a	DET
biomedich-495	219	14	potential	potential	ADJ
biomedich-495	219	15	inhibitory	inhibitory	ADJ
biomedich-495	219	16	effect	effect	NOUN
biomedich-495	219	17	on	on	ADP
biomedich-495	219	18	the	the	DET
biomedich-495	219	19	targeted	target	VERB
biomedich-495	219	20	protein	protein	NOUN
biomedich-495	219	21	.	.	PUNCT
biomedich-495	220	1	the	the	DET
biomedich-495	220	2	study	study	NOUN
biomedich-495	220	3	compared	compare	VERB
biomedich-495	220	4	the	the	DET
biomedich-495	220	5	binding	bind	VERB
biomedich-495	220	6	energies	energy	NOUN
biomedich-495	220	7	and	and	CCONJ
biomedich-495	220	8	inhibition	inhibition	VERB
biomedich-495	220	9	constants	constant	NOUN
biomedich-495	220	10	of	of	ADP
biomedich-495	220	11	the	the	DET
biomedich-495	220	12	secondary	secondary	ADJ
biomedich-495	220	13	metabolites	metabolite	NOUN
biomedich-495	220	14	with	with	ADP
biomedich-495	220	15	the	the	DET
biomedich-495	220	16	reference	reference	NOUN
biomedich-495	220	17	compound	compound	NOUN
biomedich-495	220	18	,	,	PUNCT
biomedich-495	220	19	ciprofloxacin	ciprofloxacin	PROPN
biomedich-495	220	20	,	,	PUNCT
biomedich-495	220	21	a	a	DET
biomedich-495	220	22	known	know	VERB
biomedich-495	220	23	bacterial	bacterial	ADJ
biomedich-495	220	24	dna	dna	NOUN
biomedich-495	220	25	topoisomerase	topoisomerase	NOUN
biomedich-495	220	26	iv	iv	NUM
biomedich-495	220	27	inhibitor	inhibitor	NOUN
biomedich-495	220	28	.	.	PUNCT
biomedich-495	221	1	the	the	DET
biomedich-495	221	2	findings	finding	NOUN
biomedich-495	221	3	indicated	indicate	VERB
biomedich-495	221	4	that	that	SCONJ
biomedich-495	221	5	several	several	ADJ
biomedich-495	221	6	secondary	secondary	ADJ
biomedich-495	221	7	metabolites	metabolite	NOUN
biomedich-495	221	8	,	,	PUNCT
biomedich-495	221	9	including	include	VERB
biomedich-495	221	10	apigenin	apigenin	PROPN
biomedich-495	221	11	,	,	PUNCT
biomedich-495	221	12	luteolin	luteolin	PROPN
biomedich-495	221	13	,	,	PUNCT
biomedich-495	221	14	asterol	asterol	NOUN
biomedich-495	221	15	,	,	PUNCT
biomedich-495	221	16	stigmasterol	stigmasterol	NOUN
biomedich-495	221	17	,	,	PUNCT
biomedich-495	221	18	betulin	betulin	NOUN
biomedich-495	221	19	,	,	PUNCT
biomedich-495	221	20	lupeol	lupeol	NOUN
biomedich-495	221	21	,	,	PUNCT
biomedich-495	221	22	and	and	CCONJ
biomedich-495	221	23	lupenone	lupenone	NOUN
biomedich-495	221	24	,	,	PUNCT
biomedich-495	221	25	exhibited	exhibit	VERB
biomedich-495	221	26	even	even	ADV
biomedich-495	221	27	better	well	ADV
biomedich-495	221	28	binding	bind	VERB
biomedich-495	221	29	affinity	affinity	NOUN
biomedich-495	221	30	and	and	CCONJ
biomedich-495	221	31	lower	low	ADJ
biomedich-495	221	32	inhibition	inhibition	NOUN
biomedich-495	221	33	constants	constant	NOUN
biomedich-495	221	34	than	than	ADP
biomedich-495	221	35	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	221	36	,	,	PUNCT
biomedich-495	221	37	indicating	indicate	VERB
biomedich-495	221	38	their	their	PRON
biomedich-495	221	39	potential	potential	ADJ
biomedich-495	221	40	potency	potency	NOUN
biomedich-495	221	41	towards	towards	ADP
biomedich-495	221	42	the	the	DET
biomedich-495	221	43	inhibition	inhibition	NOUN
biomedich-495	221	44	of	of	ADP
biomedich-495	221	45	dna	dna	NOUN
biomedich-495	221	46	topoisomerase	topoisomerase	NOUN
biomedich-495	221	47	iv	iv	X
biomedich-495	221	48	.	.	PUNCT
biomedich-495	222	1	when	when	SCONJ
biomedich-495	222	2	considering	consider	VERB
biomedich-495	222	3	the	the	DET
biomedich-495	222	4	binding	bind	VERB
biomedich-495	222	5	interactions	interaction	NOUN
biomedich-495	222	6	of	of	ADP
biomedich-495	222	7	those	those	DET
biomedich-495	222	8	seven	seven	NUM
biomedich-495	222	9	ligands	ligand	NOUN
biomedich-495	222	10	,	,	PUNCT
biomedich-495	222	11	ciprofloxacin	ciprofloxacin	PROPN
biomedich-495	222	12	shows	show	VERB
biomedich-495	222	13	only	only	ADV
biomedich-495	222	14	one	one	NUM
biomedich-495	222	15	hydrogen	hydrogen	NOUN
biomedich-495	222	16	bonding	bonding	NOUN
biomedich-495	222	17	interaction	interaction	NOUN
biomedich-495	222	18	with	with	ADP
biomedich-495	222	19	the	the	DET
biomedich-495	222	20	protein	protein	NOUN
biomedich-495	222	21	(	(	PUNCT
biomedich-495	222	22	with	with	ADP
biomedich-495	222	23	asp1070	asp1070	NOUN
biomedich-495	222	24	)	)	PUNCT
biomedich-495	222	25	.	.	PUNCT
biomedich-495	223	1	but	but	CCONJ
biomedich-495	223	2	apigenin	apigenin	PROPN
biomedich-495	223	3	and	and	CCONJ
biomedich-495	223	4	luteolin	luteolin	PROPN
biomedich-495	223	5	show	show	VERB
biomedich-495	223	6	three	three	NUM
biomedich-495	223	7	(	(	PUNCT
biomedich-495	223	8	with	with	ADP
biomedich-495	223	9	leu1048a	leu1048a	PROPN
biomedich-495	223	10	,	,	PUNCT
biomedich-495	223	11	leu1194a	leu1194a	NOUN
biomedich-495	223	12	&	&	CCONJ
biomedich-495	223	13	gly1197a	gly1197a	PROPN
biomedich-495	223	14	)	)	PUNCT
biomedich-495	223	15	and	and	CCONJ
biomedich-495	223	16	six	six	NUM
biomedich-495	223	17	(	(	PUNCT
biomedich-495	223	18	with	with	ADP
biomedich-495	223	19	gly1050a	gly1050a	PROPN
biomedich-495	223	20	,	,	PUNCT
biomedich-495	223	21	his1051a	his1051a	PROPN
biomedich-495	223	22	,	,	PUNCT
biomedich-495	223	23	arg1054a	arg1054a	NOUN
biomedich-495	223	24	,	,	PUNCT
biomedich-495	223	25	asn1160a	asn1160a	PROPN
biomedich-495	223	26	,	,	PUNCT
biomedich-495	223	27	&	&	CCONJ
biomedich-495	223	28	thr1161a	thr1161a	PROPN
biomedich-495	223	29	)	)	PUNCT
biomedich-495	223	30	(	(	PUNCT
biomedich-495	223	31	figure	figure	VERB
biomedich-495	223	32	3	3	NUM
biomedich-495	223	33	)	)	PUNCT
biomedich-495	223	34	hydrogen	hydrogen	NOUN
biomedich-495	223	35	bonding	bonding	NOUN
biomedich-495	223	36	interactions	interaction	NOUN
biomedich-495	223	37	with	with	ADP
biomedich-495	223	38	the	the	DET
biomedich-495	223	39	target	target	NOUN
biomedich-495	223	40	protein	protein	NOUN
biomedich-495	223	41	,	,	PUNCT
biomedich-495	223	42	respectively	respectively	ADV
biomedich-495	223	43	.	.	PUNCT
biomedich-495	224	1	lupenone	lupenone	NOUN
biomedich-495	224	2	shows	show	VERB
biomedich-495	224	3	the	the	DET
biomedich-495	224	4	lowest	low	ADJ
biomedich-495	224	5	(	(	PUNCT
biomedich-495	224	6	-6.15	-6.15	NOUN
biomedich-495	224	7	kcal	kcal	NOUN
biomedich-495	224	8	/	/	SYM
biomedich-495	224	9	mol	mol	NOUN
biomedich-495	224	10	)	)	PUNCT
biomedich-495	224	11	binding	bind	VERB
biomedich-495	224	12	affinity	affinity	NOUN
biomedich-495	224	13	towards	towards	ADP
biomedich-495	224	14	the	the	DET
biomedich-495	224	15	target	target	NOUN
biomedich-495	224	16	protein	protein	NOUN
biomedich-495	224	17	and	and	CCONJ
biomedich-495	224	18	the	the	DET
biomedich-495	224	19	highest	high	ADJ
biomedich-495	224	20	inhibition	inhibition	NOUN
biomedich-495	224	21	constant	constant	ADJ
biomedich-495	224	22	(	(	PUNCT
biomedich-495	224	23	31.03	31.03	NUM
biomedich-495	224	24	µm	µm	NOUN
biomedich-495	224	25	)	)	PUNCT
biomedich-495	224	26	from	from	ADP
biomedich-495	224	27	the	the	DET
biomedich-495	224	28	examined	examine	VERB
biomedich-495	224	29	ligands	ligand	NOUN
biomedich-495	224	30	.	.	PUNCT
biomedich-495	225	1	although	although	SCONJ
biomedich-495	225	2	it	it	PRON
biomedich-495	225	3	is	be	AUX
biomedich-495	225	4	not	not	PART
biomedich-495	225	5	much	much	ADJ
biomedich-495	225	6	as	as	ADP
biomedich-495	225	7	(	(	PUNCT
biomedich-495	225	8	-)-catechin	-)-catechin	NUM
biomedich-495	225	9	and	and	CCONJ
biomedich-495	225	10	procyanidin	procyanidin	NOUN
biomedich-495	225	11	-	-	PUNCT
biomedich-495	225	12	b2	b2	NOUN
biomedich-495	225	13	,	,	PUNCT
biomedich-495	225	14	phytochemicals	phytochemical	VERB
biomedich-495	225	15	procyanidin	procyanidin	NOUN
biomedich-495	225	16	-	-	PUNCT
biomedich-495	225	17	b3	b3	NOUN
biomedich-495	225	18	(	(	PUNCT
biomedich-495	225	19	5.59	5.59	NUM
biomedich-495	225	20	kcal	kcal	NOUN
biomedich-495	225	21	/	/	SYM
biomedich-495	225	22	mol	mol	NOUN
biomedich-495	225	23	)	)	PUNCT
biomedich-495	225	24	,	,	PUNCT
biomedich-495	225	25	b4(-5.60	b4(-5.60	PROPN
biomedich-495	225	26	kcal	kcal	PROPN
biomedich-495	225	27	/	/	SYM
biomedich-495	225	28	mol	mol	NOUN
biomedich-495	225	29	)	)	PUNCT
biomedich-495	225	30	,	,	PUNCT
biomedich-495	225	31	(	(	PUNCT
biomedich-495	225	32	-)-epicatechin	-)-epicatechin	X
biomedich-495	225	33	(	(	PUNCT
biomedich-495	225	34	5.32	5.32	NUM
biomedich-495	225	35	kcal	kcal	NOUN
biomedich-495	225	36	/	/	SYM
biomedich-495	225	37	mol	mol	NOUN
biomedich-495	225	38	)	)	PUNCT
biomedich-495	225	39	and	and	CCONJ
biomedich-495	225	40	quercetin	quercetin	NOUN
biomedich-495	225	41	(	(	PUNCT
biomedich-495	225	42	-5.36	-5.36	NOUN
biomedich-495	225	43	kcal	kcal	PROPN
biomedich-495	225	44	/	/	SYM
biomedich-495	225	45	mol	mol	NOUN
biomedich-495	225	46	)	)	PUNCT
biomedich-495	225	47	also	also	ADV
biomedich-495	225	48	exhibits	exhibit	VERB
biomedich-495	225	49	good	good	ADJ
biomedich-495	225	50	binding	binding	ADJ
biomedich-495	225	51	capabilities	capability	NOUN
biomedich-495	225	52	.	.	PUNCT
biomedich-495	226	1	major	major	ADJ
biomedich-495	226	2	types	type	NOUN
biomedich-495	226	3	of	of	ADP
biomedich-495	226	4	binding	bind	VERB
biomedich-495	226	5	interactions	interaction	NOUN
biomedich-495	226	6	between	between	ADP
biomedich-495	226	7	the	the	DET
biomedich-495	226	8	protein	protein	NOUN
biomedich-495	226	9	and	and	CCONJ
biomedich-495	226	10	the	the	DET
biomedich-495	226	11	ligands	ligand	NOUN
biomedich-495	226	12	are	be	AUX
biomedich-495	226	13	h	h	NOUN
biomedich-495	226	14	-	-	PUNCT
biomedich-495	226	15	bonding	bond	VERB
biomedich-495	226	16	and	and	CCONJ
biomedich-495	226	17	hydrophobic	hydrophobic	NOUN
biomedich-495	226	18	interactions	interaction	NOUN
biomedich-495	226	19	.	.	PUNCT
biomedich-495	227	1	other	other	ADJ
biomedich-495	227	2	than	than	ADP
biomedich-495	227	3	that	that	PRON
biomedich-495	227	4	,	,	PUNCT
biomedich-495	227	5	salt	salt	NOUN
biomedich-495	227	6	bridge	bridge	NOUN
biomedich-495	227	7	interactions	interaction	NOUN
biomedich-495	227	8	also	also	ADV
biomedich-495	227	9	can	can	AUX
biomedich-495	227	10	be	be	AUX
biomedich-495	227	11	observed	observe	VERB
biomedich-495	227	12	in	in	ADP
biomedich-495	227	13	one	one	NUM
biomedich-495	227	14	case	case	NOUN
biomedich-495	227	15	which	which	PRON
biomedich-495	227	16	is	be	AUX
biomedich-495	227	17	gallic	gallic	ADJ
biomedich-495	227	18	acid	acid	NOUN
biomedich-495	227	19	.	.	PUNCT
biomedich-495	228	1	interestingly	interestingly	ADV
biomedich-495	228	2	,	,	PUNCT
biomedich-495	228	3	in	in	ADP
biomedich-495	228	4	this	this	DET
biomedich-495	228	5	case	case	NOUN
biomedich-495	228	6	,	,	PUNCT
biomedich-495	228	7	salt	salt	NOUN
biomedich-495	228	8	bridge	bridge	NOUN
biomedich-495	228	9	interactions	interaction	NOUN
biomedich-495	228	10	have	have	AUX
biomedich-495	228	11	occurred	occur	VERB
biomedich-495	228	12	between	between	ADP
biomedich-495	228	13	the	the	DET
biomedich-495	228	14	carboxylate	carboxylate	NOUN
biomedich-495	228	15	groups	group	NOUN
biomedich-495	228	16	in	in	ADP
biomedich-495	228	17	the	the	DET
biomedich-495	228	18	ligands	ligand	NOUN
biomedich-495	228	19	and	and	CCONJ
biomedich-495	228	20	the	the	DET
biomedich-495	228	21	lys1053a	lys1053a	ADJ
biomedich-495	228	22	and	and	CCONJ
biomedich-495	228	23	arg1054a	arg1054a	NOUN
biomedich-495	228	24	amino	amino	NOUN
biomedich-495	228	25	acids	acid	NOUN
biomedich-495	228	26	.	.	PUNCT
biomedich-495	229	1	from	from	ADP
biomedich-495	229	2	the	the	DET
biomedich-495	229	3	leading	lead	VERB
biomedich-495	229	4	phytochemicals	phytochemical	NOUN
biomedich-495	229	5	observed	observe	VERB
biomedich-495	229	6	with	with	ADP
biomedich-495	229	7	the	the	DET
biomedich-495	229	8	highest	high	ADJ
biomedich-495	229	9	binding	bind	VERB
biomedich-495	229	10	affinities	affinity	NOUN
biomedich-495	229	11	,	,	PUNCT
biomedich-495	229	12	gallic	gallic	ADJ
biomedich-495	229	13	acid	acid	NOUN
biomedich-495	229	14	meets	meet	VERB
biomedich-495	229	15	lipinski	lipinski	PROPN
biomedich-495	229	16	's	's	PART
biomedich-495	229	17	and	and	CCONJ
biomedich-495	229	18	veber	veber	PROPN
biomedich-495	229	19	’s	’s	PART
biomedich-495	229	20	rules	rule	NOUN
biomedich-495	229	21	,	,	PUNCT
biomedich-495	229	22	fulfilling	fulfil	VERB
biomedich-495	229	23	strong	strong	ADJ
biomedich-495	229	24	physicochemical	physicochemical	ADJ
biomedich-495	229	25	requirements	requirement	NOUN
biomedich-495	229	26	(	(	PUNCT
biomedich-495	229	27	table	table	NOUN
biomedich-495	229	28	4	4	NUM
biomedich-495	229	29	)	)	PUNCT
biomedich-495	229	30	as	as	ADP
biomedich-495	229	31	a	a	DET
biomedich-495	229	32	potential	potential	ADJ
biomedich-495	229	33	drug	drug	NOUN
biomedich-495	229	34	.	.	PUNCT
biomedich-495	230	1	also	also	ADV
biomedich-495	230	2	,	,	PUNCT
biomedich-495	230	3	gallic	gallic	ADJ
biomedich-495	230	4	acid	acid	PROPN
biomedich-495	230	5	shows	show	VERB
biomedich-495	230	6	a	a	DET
biomedich-495	230	7	satisfactory	satisfactory	ADJ
biomedich-495	230	8	percentage	percentage	NOUN
biomedich-495	230	9	of	of	ADP
biomedich-495	230	10	absorption	absorption	NOUN
biomedich-495	230	11	through	through	ADP
biomedich-495	230	12	the	the	DET
biomedich-495	230	13	human	human	ADJ
biomedich-495	230	14	intestinal	intestinal	ADJ
biomedich-495	230	15	tract	tract	NOUN
biomedich-495	230	16	.	.	PUNCT
biomedich-495	231	1	another	another	DET
biomedich-495	231	2	important	important	ADJ
biomedich-495	231	3	characteristic	characteristic	NOUN
biomedich-495	231	4	is	be	AUX
biomedich-495	231	5	that	that	SCONJ
biomedich-495	231	6	all	all	DET
biomedich-495	231	7	the	the	DET
biomedich-495	231	8	screened	screen	VERB
biomedich-495	231	9	phytochemicals	phytochemical	NOUN
biomedich-495	231	10	from	from	ADP
biomedich-495	231	11	hygrophila	hygrophila	PROPN
biomedich-495	231	12	schulli	schulli	PROPN
biomedich-495	231	13	plant	plant	NOUN
biomedich-495	231	14	extract	extract	NOUN
biomedich-495	231	15	do	do	AUX
biomedich-495	231	16	n't	not	PART
biomedich-495	231	17	show	show	VERB
biomedich-495	231	18	hepatotoxicity	hepatotoxicity	NOUN
biomedich-495	231	19	(	(	PUNCT
biomedich-495	231	20	table	table	NOUN
biomedich-495	231	21	4	4	NUM
biomedich-495	231	22	)	)	PUNCT
biomedich-495	231	23	,	,	PUNCT
biomedich-495	231	24	even	even	ADV
biomedich-495	231	25	though	though	SCONJ
biomedich-495	231	26	the	the	DET
biomedich-495	231	27	well	well	ADV
biomedich-495	231	28	-	-	PUNCT
biomedich-495	231	29	known	know	VERB
biomedich-495	231	30	commercially	commercially	ADV
biomedich-495	231	31	available	available	ADJ
biomedich-495	231	32	antibiotic	antibiotic	ADJ
biomedich-495	231	33	ciprofloxacin	ciprofloxacin	NOUN
biomedich-495	231	34	shows	show	VERB
biomedich-495	231	35	some	some	DET
biomedich-495	231	36	level	level	NOUN
biomedich-495	231	37	of	of	ADP
biomedich-495	231	38	hepatotoxicity	hepatotoxicity	NOUN
biomedich-495	231	39	.	.	PUNCT
biomedich-495	232	1	in	in	ADP
biomedich-495	232	2	pharmacokinetics	pharmacokinetic	NOUN
biomedich-495	232	3	and	and	CCONJ
biomedich-495	232	4	toxicity	toxicity	NOUN
biomedich-495	232	5	analysis	analysis	NOUN
biomedich-495	232	6	,	,	PUNCT
biomedich-495	232	7	it	it	PRON
biomedich-495	232	8	is	be	AUX
biomedich-495	232	9	categorized	categorize	VERB
biomedich-495	232	10	that	that	SCONJ
biomedich-495	232	11	values	value	NOUN
biomedich-495	232	12	between	between	ADP
biomedich-495	232	13	-7	-7	NOUN
biomedich-495	233	1	and	and	CCONJ
biomedich-495	233	2	-2	-2	INTJ
biomedich-495	233	3	log	log	VERB
biomedich-495	233	4	mol	mol	PROPN
biomedich-495	233	5	/	/	SYM
biomedich-495	233	6	l	l	NOUN
biomedich-495	233	7	as	as	ADP
biomedich-495	233	8	water	water	NOUN
biomedich-495	233	9	“	"	PUNCT
biomedich-495	233	10	soluble	soluble	ADJ
biomedich-495	233	11	“	"	PUNCT
biomedich-495	233	12	compounds	compound	NOUN
biomedich-495	233	13	.	.	PUNCT
biomedich-495	234	1	interestingly	interestingly	ADV
biomedich-495	234	2	all	all	DET
biomedich-495	234	3	the	the	DET
biomedich-495	234	4	compounds	compound	NOUN
biomedich-495	234	5	examined	examine	VERB
biomedich-495	234	6	come	come	VERB
biomedich-495	234	7	under	under	ADP
biomedich-495	234	8	that	that	DET
biomedich-495	234	9	category	category	NOUN
biomedich-495	234	10	.	.	PUNCT
biomedich-495	235	1	out	out	ADP
biomedich-495	235	2	of	of	ADP
biomedich-495	235	3	the	the	DET
biomedich-495	235	4	phytochemicals	phytochemical	NOUN
biomedich-495	235	5	from	from	ADP
biomedich-495	235	6	the	the	DET
biomedich-495	235	7	hygrophila	hygrophila	PROPN
biomedich-495	235	8	schulli	schulli	PROPN
biomedich-495	235	9	plant	plant	PROPN
biomedich-495	235	10	extract	extract	NOUN
biomedich-495	235	11	assessed	assess	VERB
biomedich-495	235	12	,	,	PUNCT
biomedich-495	235	13	including	include	VERB
biomedich-495	235	14	the	the	DET
biomedich-495	235	15	reference	reference	NOUN
biomedich-495	235	16	compound	compound	VERB
biomedich-495	235	17	most	most	ADJ
biomedich-495	235	18	of	of	ADP
biomedich-495	235	19	the	the	DET
biomedich-495	235	20	chemicals	chemical	NOUN
biomedich-495	235	21	acted	act	VERB
biomedich-495	235	22	as	as	ADP
biomedich-495	235	23	a	a	DET
biomedich-495	235	24	substrate	substrate	NOUN
biomedich-495	235	25	for	for	ADP
biomedich-495	235	26	cytochromes	cytochrome	NOUN
biomedich-495	235	27	p450	p450	NUM
biomedich-495	235	28	isozymes	isozyme	NOUN
biomedich-495	235	29	.	.	PUNCT
biomedich-495	236	1	however	however	ADV
biomedich-495	236	2	,	,	PUNCT
biomedich-495	236	3	predicted	predict	VERB
biomedich-495	236	4	data	datum	NOUN
biomedich-495	236	5	revealed	reveal	VERB
biomedich-495	236	6	that	that	SCONJ
biomedich-495	236	7	apigenin	apigenin	PROPN
biomedich-495	236	8	,	,	PUNCT
biomedich-495	236	9	quercetin	quercetin	NOUN
biomedich-495	236	10	,	,	PUNCT
biomedich-495	236	11	asterol	asterol	NOUN
biomedich-495	236	12	,	,	PUNCT
biomedich-495	236	13	and	and	CCONJ
biomedich-495	236	14	ellagic	ellagic	PROPN
biomedich-495	236	15	acid	acid	NOUN
biomedich-495	236	16	have	have	VERB
biomedich-495	236	17	the	the	DET
biomedich-495	236	18	potential	potential	NOUN
biomedich-495	236	19	to	to	PART
biomedich-495	236	20	inhibit	inhibit	VERB
biomedich-495	236	21	cyp1a2	cyp1a2	ADJ
biomedich-495	236	22	isozyme	isozyme	NOUN
biomedich-495	236	23	.	.	PUNCT
biomedich-495	237	1	this	this	PRON
biomedich-495	237	2	predicted	predict	VERB
biomedich-495	237	3	data	datum	NOUN
biomedich-495	237	4	further	far	ADV
biomedich-495	237	5	revealed	reveal	VERB
biomedich-495	237	6	that	that	SCONJ
biomedich-495	237	7	none	none	NOUN
biomedich-495	237	8	of	of	ADP
biomedich-495	237	9	the	the	DET
biomedich-495	237	10	phytochemicals	phytochemical	NOUN
biomedich-495	237	11	do	do	AUX
biomedich-495	237	12	n’t	not	PART
biomedich-495	237	13	have	have	VERB
biomedich-495	237	14	the	the	DET
biomedich-495	237	15	potential	potential	NOUN
biomedich-495	237	16	to	to	PART
biomedich-495	237	17	inhibit	inhibit	VERB
biomedich-495	237	18	cyp2d6	cyp2d6	NOUN
biomedich-495	237	19	and	and	CCONJ
biomedich-495	237	20	cyp3a4	cyp3a4	NOUN
biomedich-495	237	21	isozymes	isozyme	NOUN
biomedich-495	237	22	.	.	PUNCT
biomedich-495	238	1	those	those	DET
biomedich-495	238	2	predicted	predict	VERB
biomedich-495	238	3	data	datum	NOUN
biomedich-495	238	4	revealed	reveal	VERB
biomedich-495	238	5	that	that	SCONJ
biomedich-495	238	6	lupeol	lupeol	NOUN
biomedich-495	238	7	,	,	PUNCT
biomedich-495	238	8	lupenone	lupenone	NOUN
biomedich-495	238	9	,	,	PUNCT
biomedich-495	238	10	betulin	betulin	NOUN
biomedich-495	238	11	,	,	PUNCT
biomedich-495	238	12	and	and	CCONJ
biomedich-495	238	13	asterol	asterol	NOUN
biomedich-495	238	14	have	have	VERB
biomedich-495	238	15	the	the	DET
biomedich-495	238	16	potential	potential	NOUN
biomedich-495	238	17	to	to	PART
biomedich-495	238	18	inhibit	inhibit	VERB
biomedich-495	238	19	cyp3a4	cyp3a4	PROPN
biomedich-495	238	20	isozyme	isozyme	NOUN
biomedich-495	238	21	.	.	PUNCT
biomedich-495	239	1	predicted	predict	VERB
biomedich-495	239	2	data	datum	NOUN
biomedich-495	239	3	revealed	reveal	VERB
biomedich-495	239	4	that	that	SCONJ
biomedich-495	239	5	apigenin	apigenin	PROPN
biomedich-495	239	6	has	have	VERB
biomedich-495	239	7	the	the	DET
biomedich-495	239	8	potential	potential	NOUN
biomedich-495	239	9	to	to	PART
biomedich-495	239	10	inhibit	inhibit	VERB
biomedich-495	239	11	cyp2c19	cyp2c19	NOUN
biomedich-495	239	12	isozyme	isozyme	NOUN
biomedich-495	239	13	.	.	PUNCT
biomedich-495	240	1	those	those	DET
biomedich-495	240	2	predicted	predict	VERB
biomedich-495	240	3	data	datum	NOUN
biomedich-495	240	4	revealed	reveal	VERB
biomedich-495	240	5	that	that	SCONJ
biomedich-495	240	6	luteolin	luteolin	PROPN
biomedich-495	240	7	has	have	VERB
biomedich-495	240	8	the	the	DET
biomedich-495	240	9	potential	potential	NOUN
biomedich-495	240	10	to	to	PART
biomedich-495	240	11	inhibit	inhibit	VERB
biomedich-495	240	12	cyp2c9	cyp2c9	NOUN
biomedich-495	240	13	isozyme	isozyme	NOUN
biomedich-495	240	14	.	.	PUNCT
biomedich-495	241	1	those	those	DET
biomedich-495	241	2	predicted	predict	VERB
biomedich-495	241	3	data	datum	NOUN
biomedich-495	241	4	revealed	reveal	VERB
biomedich-495	241	5	that	that	SCONJ
biomedich-495	241	6	asterol	asterol	NOUN
biomedich-495	241	7	has	have	VERB
biomedich-495	241	8	the	the	DET
biomedich-495	241	9	potential	potential	NOUN
biomedich-495	241	10	to	to	PART
biomedich-495	241	11	inhibit	inhibit	VERB
biomedich-495	241	12	cyp2d6	cyp2d6	NOUN
biomedich-495	241	13	isozyme	isozyme	NOUN
biomedich-495	241	14	.	.	PUNCT
biomedich-495	242	1	furthermore	furthermore	ADV
biomedich-495	242	2	,	,	PUNCT
biomedich-495	242	3	the	the	DET
biomedich-495	242	4	study	study	NOUN
biomedich-495	242	5	analyzed	analyze	VERB
biomedich-495	242	6	the	the	DET
biomedich-495	242	7	binding	bind	VERB
biomedich-495	242	8	interactions	interaction	NOUN
biomedich-495	242	9	of	of	ADP
biomedich-495	242	10	the	the	DET
biomedich-495	242	11	top	top	ADV
biomedich-495	242	12	-	-	PUNCT
biomedich-495	242	13	ranked	rank	VERB
biomedich-495	242	14	phytochemical	phytochemical	ADJ
biomedich-495	242	15	structures	structure	NOUN
biomedich-495	242	16	with	with	ADP
biomedich-495	242	17	the	the	DET
biomedich-495	242	18	target	target	NOUN
biomedich-495	242	19	protein	protein	NOUN
biomedich-495	242	20	,	,	PUNCT
biomedich-495	242	21	highlighting	highlight	VERB
biomedich-495	242	22	the	the	DET
biomedich-495	242	23	role	role	NOUN
biomedich-495	242	24	of	of	ADP
biomedich-495	242	25	hydroxyl	hydroxyl	NOUN
biomedich-495	242	26	groups	group	NOUN
biomedich-495	242	27	in	in	ADP
biomedich-495	242	28	establishing	establish	VERB
biomedich-495	242	29	potent	potent	ADJ
biomedich-495	242	30	hydrogen	hydrogen	NOUN
biomedich-495	242	31	bonds	bond	NOUN
biomedich-495	242	32	with	with	ADP
biomedich-495	242	33	amino	amino	NOUN
biomedich-495	242	34	acid	acid	NOUN
biomedich-495	242	35	residues	residue	NOUN
biomedich-495	242	36	in	in	ADP
biomedich-495	242	37	the	the	DET
biomedich-495	242	38	binding	bind	VERB
biomedich-495	242	39	pockets	pocket	NOUN
biomedich-495	242	40	.	.	PUNCT
biomedich-495	243	1	the	the	DET
biomedich-495	243	2	interactions	interaction	NOUN
biomedich-495	243	3	were	be	AUX
biomedich-495	243	4	visualized	visualize	VERB
biomedich-495	243	5	and	and	CCONJ
biomedich-495	243	6	analyzed	analyze	VERB
biomedich-495	243	7	to	to	PART
biomedich-495	243	8	understand	understand	VERB
biomedich-495	243	9	the	the	DET
biomedich-495	243	10	molecular	molecular	ADJ
biomedich-495	243	11	mechanisms	mechanism	NOUN
biomedich-495	243	12	underlying	underlie	VERB
biomedich-495	243	13	the	the	DET
biomedich-495	243	14	inhibitory	inhibitory	ADJ
biomedich-495	243	15	effects	effect	NOUN
biomedich-495	243	16	of	of	ADP
biomedich-495	243	17	the	the	DET
biomedich-495	243	18	secondary	secondary	ADJ
biomedich-495	243	19	metabolites	metabolite	NOUN
biomedich-495	243	20	.	.	PUNCT
biomedich-495	244	1	in	in	ADP
biomedich-495	244	2	addition	addition	NOUN
biomedich-495	244	3	to	to	ADP
biomedich-495	244	4	the	the	DET
biomedich-495	244	5	molecular	molecular	ADJ
biomedich-495	244	6	docking	docking	NOUN
biomedich-495	244	7	simulations	simulation	NOUN
biomedich-495	244	8	,	,	PUNCT
biomedich-495	244	9	the	the	DET
biomedich-495	244	10	study	study	NOUN
biomedich-495	244	11	also	also	ADV
biomedich-495	244	12	conducted	conduct	VERB
biomedich-495	244	13	in	in	ADP
biomedich-495	244	14	-	-	PUNCT
biomedich-495	244	15	silico	silico	NOUN
biomedich-495	244	16	physicochemical	physicochemical	ADJ
biomedich-495	244	17	and	and	CCONJ
biomedich-495	244	18	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	244	19	parameter	parameter	NOUN
biomedich-495	244	20	predictions	prediction	NOUN
biomedich-495	244	21	for	for	ADP
biomedich-495	244	22	the	the	DET
biomedich-495	244	23	studied	studied	ADJ
biomedich-495	244	24	secondary	secondary	ADJ
biomedich-495	244	25	metabolites	metabolite	NOUN
biomedich-495	244	26	.	.	PUNCT
biomedich-495	245	1	the	the	DET
biomedich-495	245	2	analysis	analysis	NOUN
biomedich-495	245	3	evaluated	evaluate	VERB
biomedich-495	245	4	drug	drug	NOUN
biomedich-495	245	5	-	-	PUNCT
biomedich-495	245	6	likeness	likeness	NOUN
biomedich-495	245	7	,	,	PUNCT
biomedich-495	245	8	physicochemical	physicochemical	ADJ
biomedich-495	245	9	properties	property	NOUN
biomedich-495	245	10	,	,	PUNCT
biomedich-495	245	11	admet	admet	PROPN
biomedich-495	245	12	characteristics	characteristic	NOUN
biomedich-495	245	13	,	,	PUNCT
biomedich-495	245	14	and	and	CCONJ
biomedich-495	245	15	predicted	predict	VERB
biomedich-495	245	16	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	245	17	parameters	parameter	NOUN
biomedich-495	245	18	of	of	ADP
biomedich-495	245	19	the	the	DET
biomedich-495	245	20	secondary	secondary	ADJ
biomedich-495	245	21	metabolites	metabolite	NOUN
biomedich-495	245	22	,	,	PUNCT
biomedich-495	245	23	providing	provide	VERB
biomedich-495	245	24	insights	insight	NOUN
biomedich-495	245	25	into	into	ADP
biomedich-495	245	26	their	their	PRON
biomedich-495	245	27	potential	potential	NOUN
biomedich-495	245	28	as	as	ADP
biomedich-495	245	29	antimicrobial	antimicrobial	ADJ
biomedich-495	245	30	agents	agent	NOUN
biomedich-495	245	31	derived	derive	VERB
biomedich-495	245	32	from	from	ADP
biomedich-495	245	33	natural	natural	ADJ
biomedich-495	245	34	sources	source	NOUN
biomedich-495	245	35	.	.	PUNCT
biomedich-495	246	1	perera	perera	PROPN
biomedich-495	246	2	&	&	CCONJ
biomedich-495	246	3	lawan	lawan	PROPN
biomedich-495	246	4	–	–	PUNCT
biomedich-495	246	5	antibacterial	antibacterial	ADJ
biomedich-495	246	6	potential	potential	NOUN
biomedich-495	246	7	of	of	ADP
biomedich-495	246	8	hygrophila	hygrophila	PROPN
biomedich-495	246	9	schulli	schulli	PROPN
biomedich-495	246	10	213	213	NUM
biomedich-495	246	11	the	the	DET
biomedich-495	246	12	comprehensive	comprehensive	ADJ
biomedich-495	246	13	in	in	ADP
biomedich-495	246	14	-	-	PUNCT
biomedich-495	246	15	silico	silico	NOUN
biomedich-495	246	16	analysis	analysis	NOUN
biomedich-495	246	17	presented	present	VERB
biomedich-495	246	18	in	in	ADP
biomedich-495	246	19	the	the	DET
biomedich-495	246	20	document	document	NOUN
biomedich-495	246	21	positions	position	NOUN
biomedich-495	246	22	the	the	DET
biomedich-495	246	23	secondary	secondary	ADJ
biomedich-495	246	24	metabolites	metabolite	NOUN
biomedich-495	246	25	from	from	ADP
biomedich-495	246	26	hygrophila	hygrophila	PROPN
biomedich-495	246	27	schulli	schulli	PROPN
biomedich-495	246	28	as	as	ADP
biomedich-495	246	29	promising	promise	VERB
biomedich-495	246	30	candidates	candidate	NOUN
biomedich-495	246	31	for	for	ADP
biomedich-495	246	32	further	further	ADJ
biomedich-495	246	33	experimental	experimental	ADJ
biomedich-495	246	34	validations	validation	NOUN
biomedich-495	246	35	as	as	ADP
biomedich-495	246	36	potential	potential	ADJ
biomedich-495	246	37	inhibitors	inhibitor	NOUN
biomedich-495	246	38	of	of	ADP
biomedich-495	246	39	bacterial	bacterial	ADJ
biomedich-495	246	40	dna	dna	NOUN
biomedich-495	246	41	topoisomerase	topoisomerase	NOUN
biomedich-495	246	42	iv	iv	NOUN
biomedich-495	246	43	.	.	PUNCT
biomedich-495	247	1	the	the	DET
biomedich-495	247	2	findings	finding	NOUN
biomedich-495	247	3	contribute	contribute	VERB
biomedich-495	247	4	valuable	valuable	ADJ
biomedich-495	247	5	information	information	NOUN
biomedich-495	247	6	to	to	ADP
biomedich-495	247	7	the	the	DET
biomedich-495	247	8	understanding	understanding	NOUN
biomedich-495	247	9	of	of	ADP
biomedich-495	247	10	the	the	DET
biomedich-495	247	11	molecular	molecular	ADJ
biomedich-495	247	12	interactions	interaction	NOUN
biomedich-495	247	13	between	between	ADP
biomedich-495	247	14	plant	plant	NOUN
biomedich-495	247	15	-	-	PUNCT
biomedich-495	247	16	derived	derive	VERB
biomedich-495	247	17	secondary	secondary	ADJ
biomedich-495	247	18	metabolites	metabolite	NOUN
biomedich-495	247	19	and	and	CCONJ
biomedich-495	247	20	bacterial	bacterial	ADJ
biomedich-495	247	21	dna	dna	NOUN
biomedich-495	247	22	topoisomerase	topoisomerase	NOUN
biomedich-495	247	23	iv	iv	NUM
biomedich-495	247	24	,	,	PUNCT
biomedich-495	247	25	laying	lay	VERB
biomedich-495	247	26	the	the	DET
biomedich-495	247	27	groundwork	groundwork	NOUN
biomedich-495	247	28	for	for	ADP
biomedich-495	247	29	the	the	DET
biomedich-495	247	30	development	development	NOUN
biomedich-495	247	31	of	of	ADP
biomedich-495	247	32	novel	novel	ADJ
biomedich-495	247	33	antimicrobial	antimicrobial	ADJ
biomedich-495	247	34	agents	agent	NOUN
biomedich-495	247	35	derived	derive	VERB
biomedich-495	247	36	from	from	ADP
biomedich-495	247	37	natural	natural	ADJ
biomedich-495	247	38	sources	source	NOUN
biomedich-495	247	39	.	.	PUNCT
biomedich-495	248	1	this	this	DET
biomedich-495	248	2	in	in	ADP
biomedich-495	248	3	-	-	PUNCT
biomedich-495	248	4	silico	silico	NOUN
biomedich-495	248	5	exploration	exploration	NOUN
biomedich-495	248	6	offers	offer	VERB
biomedich-495	248	7	a	a	DET
biomedich-495	248	8	sustainable	sustainable	ADJ
biomedich-495	248	9	and	and	CCONJ
biomedich-495	248	10	effective	effective	ADJ
biomedich-495	248	11	approach	approach	NOUN
biomedich-495	248	12	in	in	ADP
biomedich-495	248	13	the	the	DET
biomedich-495	248	14	ongoing	ongoing	ADJ
biomedich-495	248	15	battle	battle	NOUN
biomedich-495	248	16	against	against	ADP
biomedich-495	248	17	antibiotic	antibiotic	NOUN
biomedich-495	248	18	-	-	PUNCT
biomedich-495	248	19	resistant	resistant	ADJ
biomedich-495	248	20	bacterial	bacterial	ADJ
biomedich-495	248	21	infections	infection	NOUN
biomedich-495	248	22	.	.	PUNCT
biomedich-495	249	1	overall	overall	ADV
biomedich-495	249	2	,	,	PUNCT
biomedich-495	249	3	the	the	DET
biomedich-495	249	4	study	study	NOUN
biomedich-495	249	5	provides	provide	VERB
biomedich-495	249	6	a	a	DET
biomedich-495	249	7	strong	strong	ADJ
biomedich-495	249	8	foundation	foundation	NOUN
biomedich-495	249	9	for	for	ADP
biomedich-495	249	10	future	future	ADJ
biomedich-495	249	11	experimental	experimental	ADJ
biomedich-495	249	12	investigations	investigation	NOUN
biomedich-495	249	13	to	to	PART
biomedich-495	249	14	validate	validate	VERB
biomedich-495	249	15	the	the	DET
biomedich-495	249	16	inhibitory	inhibitory	ADJ
biomedich-495	249	17	effects	effect	NOUN
biomedich-495	249	18	of	of	ADP
biomedich-495	249	19	the	the	DET
biomedich-495	249	20	identified	identify	VERB
biomedich-495	249	21	secondary	secondary	ADJ
biomedich-495	249	22	metabolites	metabolite	NOUN
biomedich-495	249	23	from	from	ADP
biomedich-495	249	24	hygrophila	hygrophila	PROPN
biomedich-495	249	25	schulli	schulli	PROPN
biomedich-495	249	26	on	on	ADP
biomedich-495	249	27	bacterial	bacterial	ADJ
biomedich-495	249	28	dna	dna	NOUN
biomedich-495	249	29	topoisomerase	topoisomerase	NOUN
biomedich-495	249	30	iv	iv	ADP
biomedich-495	249	31	,	,	PUNCT
biomedich-495	249	32	potentially	potentially	ADV
biomedich-495	249	33	leading	lead	VERB
biomedich-495	249	34	to	to	ADP
biomedich-495	249	35	the	the	DET
biomedich-495	249	36	development	development	NOUN
biomedich-495	249	37	of	of	ADP
biomedich-495	249	38	novel	novel	ADJ
biomedich-495	249	39	antimicrobial	antimicrobial	ADJ
biomedich-495	249	40	agents	agent	NOUN
biomedich-495	249	41	with	with	ADP
biomedich-495	249	42	diverse	diverse	ADJ
biomedich-495	249	43	pharmacological	pharmacological	ADJ
biomedich-495	249	44	properties	property	NOUN
biomedich-495	249	45	.	.	PUNCT
biomedich-495	250	1	conclusions	conclusion	NOUN
biomedich-495	250	2	selected	select	VERB
biomedich-495	250	3	secondary	secondary	ADJ
biomedich-495	250	4	metabolites	metabolite	NOUN
biomedich-495	250	5	found	find	VERB
biomedich-495	250	6	in	in	ADP
biomedich-495	250	7	hygrophila	hygrophila	PROPN
biomedich-495	250	8	schulli	schulli	PROPN
biomedich-495	250	9	plant	plant	NOUN
biomedich-495	250	10	extract	extract	NOUN
biomedich-495	250	11	were	be	AUX
biomedich-495	250	12	tested	test	VERB
biomedich-495	250	13	in	in	ADP
biomedich-495	250	14	silico	silico	NOUN
biomedich-495	250	15	for	for	ADP
biomedich-495	250	16	their	their	PRON
biomedich-495	250	17	potential	potential	ADJ
biomedich-495	250	18	inhibitory	inhibitory	ADJ
biomedich-495	250	19	action	action	NOUN
biomedich-495	250	20	towards	towards	ADP
biomedich-495	250	21	topoisomerase	topoisomerase	NOUN
biomedich-495	250	22	iv	iv	NUM
biomedich-495	250	23	enzyme	enzyme	NOUN
biomedich-495	250	24	,	,	PUNCT
biomedich-495	250	25	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	250	26	and	and	CCONJ
biomedich-495	250	27	physicochemical	physicochemical	ADJ
biomedich-495	250	28	properties	property	NOUN
biomedich-495	250	29	,	,	PUNCT
biomedich-495	250	30	and	and	CCONJ
biomedich-495	250	31	compared	compare	VERB
biomedich-495	250	32	with	with	ADP
biomedich-495	250	33	the	the	DET
biomedich-495	250	34	commercial	commercial	ADJ
biomedich-495	250	35	antibiotic	antibiotic	NOUN
biomedich-495	250	36	,	,	PUNCT
biomedich-495	250	37	ciprofloxacin	ciprofloxacin	PROPN
biomedich-495	250	38	.	.	PUNCT
biomedich-495	251	1	out	out	ADP
biomedich-495	251	2	of	of	ADP
biomedich-495	251	3	the	the	DET
biomedich-495	251	4	eleven	eleven	NUM
biomedich-495	251	5	phytochemicals	phytochemical	NOUN
biomedich-495	251	6	assessed	assess	VERB
biomedich-495	251	7	,	,	PUNCT
biomedich-495	251	8	lupeol	lupeol	NOUN
biomedich-495	251	9	and	and	CCONJ
biomedich-495	251	10	lupenone	lupenone	NOUN
biomedich-495	251	11	indicated	indicate	VERB
biomedich-495	251	12	the	the	DET
biomedich-495	251	13	best	good	ADJ
biomedich-495	251	14	receptor	receptor	NOUN
biomedich-495	251	15	inhibition	inhibition	NOUN
biomedich-495	251	16	capabilities	capability	NOUN
biomedich-495	251	17	.	.	PUNCT
biomedich-495	252	1	comprehensive	comprehensive	ADJ
biomedich-495	252	2	docking	docking	NOUN
biomedich-495	252	3	,	,	PUNCT
biomedich-495	252	4	pharmacokinetic	pharmacokinetic	ADJ
biomedich-495	252	5	,	,	PUNCT
biomedich-495	252	6	and	and	CCONJ
biomedich-495	252	7	physicochemical	physicochemical	ADJ
biomedich-495	252	8	tests	test	NOUN
biomedich-495	252	9	indicated	indicate	VERB
biomedich-495	252	10	that	that	SCONJ
biomedich-495	252	11	lupenone	lupenone	NOUN
biomedich-495	252	12	would	would	AUX
biomedich-495	252	13	be	be	AUX
biomedich-495	252	14	a	a	DET
biomedich-495	252	15	viable	viable	ADJ
biomedich-495	252	16	topoisomerase	topoisomerase	NOUN
biomedich-495	252	17	iv	iv	NUM
biomedich-495	252	18	inhibitor	inhibitor	NOUN
biomedich-495	252	19	because	because	SCONJ
biomedich-495	252	20	it	it	PRON
biomedich-495	252	21	binds	bind	VERB
biomedich-495	252	22	firmly	firmly	ADV
biomedich-495	252	23	to	to	ADP
biomedich-495	252	24	the	the	DET
biomedich-495	252	25	binding	bind	VERB
biomedich-495	252	26	pocket	pocket	NOUN
biomedich-495	252	27	,	,	PUNCT
biomedich-495	252	28	inhibiting	inhibit	VERB
biomedich-495	252	29	the	the	DET
biomedich-495	252	30	native	native	ADJ
biomedich-495	252	31	conformation	conformation	NOUN
biomedich-495	252	32	of	of	ADP
biomedich-495	252	33	the	the	DET
biomedich-495	252	34	protein	protein	NOUN
biomedich-495	252	35	.	.	PUNCT
biomedich-495	253	1	hence	hence	ADV
biomedich-495	253	2	,	,	PUNCT
biomedich-495	253	3	lupenone	lupenone	NOUN
biomedich-495	253	4	is	be	AUX
biomedich-495	253	5	an	an	DET
biomedich-495	253	6	exceptional	exceptional	ADJ
biomedich-495	253	7	candidate	candidate	NOUN
biomedich-495	253	8	for	for	ADP
biomedich-495	253	9	further	far	ADV
biomedich-495	253	10	in	in	ADP
biomedich-495	253	11	vitro	vitro	NOUN
biomedich-495	253	12	/	/	SYM
biomedich-495	253	13	in	in	ADP
biomedich-495	253	14	vivo	vivo	ADJ
biomedich-495	253	15	studies	study	NOUN
biomedich-495	253	16	.	.	PUNCT
biomedich-495	254	1	authors	author	NOUN
biomedich-495	254	2	’	’	PART
biomedich-495	254	3	contributions	contribution	NOUN
biomedich-495	254	4	:	:	PUNCT
biomedich-495	254	5	data	datum	NOUN
biomedich-495	254	6	analysis	analysis	NOUN
biomedich-495	254	7	,	,	PUNCT
biomedich-495	254	8	computational	computational	ADJ
biomedich-495	254	9	investigations	investigation	NOUN
biomedich-495	254	10	,	,	PUNCT
biomedich-495	254	11	and	and	CCONJ
biomedich-495	254	12	study	study	NOUN
biomedich-495	254	13	design	design	NOUN
biomedich-495	254	14	were	be	AUX
biomedich-495	254	15	completed	complete	VERB
biomedich-495	254	16	by	by	ADP
biomedich-495	254	17	p.	p.	PROPN
biomedich-495	254	18	dilshan	dilshan	PROPN
biomedich-495	254	19	and	and	CCONJ
biomedich-495	254	20	h.	h.	PROPN
biomedich-495	254	21	lawan	lawan	PROPN
biomedich-495	254	22	.	.	PUNCT
biomedich-495	255	1	manuscript	manuscript	NOUN
biomedich-495	255	2	written	write	VERB
biomedich-495	255	3	and	and	CCONJ
biomedich-495	255	4	reviewed	review	VERB
biomedich-495	255	5	by	by	ADP
biomedich-495	255	6	p.	p.	PROPN
biomedich-495	255	7	dilshan	dilshan	PROPN
biomedich-495	255	8	,	,	PUNCT
biomedich-495	255	9	h.	h.	PROPN
biomedich-495	255	10	lawan	lawan	PROPN
biomedich-495	255	11	.	.	PUNCT
biomedich-495	256	1	the	the	DET
biomedich-495	256	2	completed	complete	VERB
biomedich-495	256	3	manuscript	manuscript	NOUN
biomedich-495	256	4	has	have	AUX
biomedich-495	256	5	been	be	AUX
biomedich-495	256	6	read	read	VERB
biomedich-495	256	7	and	and	CCONJ
biomedich-495	256	8	approved	approve	VERB
biomedich-495	256	9	by	by	ADP
biomedich-495	256	10	all	all	DET
biomedich-495	256	11	authors	author	NOUN
biomedich-495	256	12	.	.	PUNCT
biomedich-495	257	1	competing	compete	VERB
biomedich-495	257	2	interests	interest	NOUN
biomedich-495	257	3	:	:	PUNCT
biomedich-495	257	4	the	the	DET
biomedich-495	257	5	authors	author	NOUN
biomedich-495	257	6	declare	declare	VERB
biomedich-495	257	7	that	that	SCONJ
biomedich-495	257	8	there	there	PRON
biomedich-495	257	9	are	be	VERB
biomedich-495	257	10	no	no	DET
biomedich-495	257	11	competing	compete	VERB
biomedich-495	257	12	interests	interest	NOUN
biomedich-495	257	13	.	.	PUNCT
biomedich-495	258	1	references	reference	NOUN
biomedich-495	258	2	bourgaud	bourgaud	VERB
biomedich-495	258	3	,	,	PUNCT
biomedich-495	258	4	f.	f.	PROPN
biomedich-495	258	5	,	,	PUNCT
biomedich-495	258	6	gravot	gravot	PROPN
biomedich-495	258	7	,	,	PUNCT
biomedich-495	258	8	a.	a.	NOUN
biomedich-495	258	9	,	,	PUNCT
biomedich-495	258	10	milesi	milesi	PROPN
biomedich-495	258	11	,	,	PUNCT
biomedich-495	258	12	s.	s.	PROPN
biomedich-495	258	13	,	,	PUNCT
biomedich-495	258	14	&	&	CCONJ
biomedich-495	258	15	gontier	gontier	PROPN
biomedich-495	258	16	,	,	PUNCT
biomedich-495	258	17	e.	e.	PROPN
biomedich-495	258	18	(	(	PUNCT
biomedich-495	258	19	2001	2001	NUM
biomedich-495	258	20	)	)	PUNCT
biomedich-495	258	21	.	.	PUNCT
biomedich-495	259	1	production	production	NOUN
biomedich-495	259	2	of	of	ADP
biomedich-495	259	3	plant	plant	NOUN
biomedich-495	259	4	secondary	secondary	ADJ
biomedich-495	259	5	metabolites	metabolite	NOUN
biomedich-495	259	6	:	:	PUNCT
biomedich-495	259	7	a	a	DET
biomedich-495	259	8	historical	historical	ADJ
biomedich-495	259	9	perspective	perspective	NOUN
biomedich-495	259	10	.	.	PUNCT
biomedich-495	260	1	plant	plant	NOUN
biomedich-495	260	2	science	science	NOUN
biomedich-495	260	3	,	,	PUNCT
biomedich-495	260	4	161(5	161(5	NUM
biomedich-495	260	5	)	)	PUNCT
biomedich-495	260	6	,	,	PUNCT
biomedich-495	260	7	839–851	839–851	NUM
biomedich-495	260	8	.	.	PUNCT
biomedich-495	261	1	https://doi.org/10.1016/s0168-9452(01)00490-3	https://doi.org/10.1016/s0168-9452(01)00490-3	PROPN
biomedich-495	261	2	chandran	chandran	PROPN
biomedich-495	261	3	,	,	PUNCT
biomedich-495	261	4	r.	r.	PROPN
biomedich-495	261	5	p.	p.	PROPN
biomedich-495	261	6	,	,	PUNCT
biomedich-495	261	7	manju	manju	PROPN
biomedich-495	261	8	,	,	PUNCT
biomedich-495	261	9	s.	s.	PROPN
biomedich-495	261	10	,	,	PUNCT
biomedich-495	261	11	vysakhi	vysakhi	PROPN
biomedich-495	261	12	,	,	PUNCT
biomedich-495	261	13	m.	m.	NOUN
biomedich-495	261	14	v.	v.	PROPN
biomedich-495	261	15	,	,	PUNCT
biomedich-495	261	16	shaji	shaji	PROPN
biomedich-495	261	17	,	,	PUNCT
biomedich-495	261	18	p.	p.	PROPN
biomedich-495	261	19	k.	k.	PROPN
biomedich-495	261	20	,	,	PUNCT
biomedich-495	261	21	&	&	CCONJ
biomedich-495	261	22	nair	nair	PROPN
biomedich-495	261	23	,	,	PUNCT
biomedich-495	261	24	g.	g.	PROPN
biomedich-495	261	25	a.	a.	PROPN
biomedich-495	261	26	(	(	PUNCT
biomedich-495	261	27	2013	2013	NUM
biomedich-495	261	28	)	)	PUNCT
biomedich-495	261	29	.	.	PUNCT
biomedich-495	262	1	in	in	ADP
biomedich-495	262	2	vitro	vitro	X
biomedich-495	262	3	antimicrobial	antimicrobial	ADJ
biomedich-495	262	4	activities	activity	NOUN
biomedich-495	262	5	of	of	ADP
biomedich-495	262	6	hygrophila	hygrophila	PROPN
biomedich-495	262	7	schulli	schulli	PROPN
biomedich-495	262	8	(	(	PUNCT
biomedich-495	262	9	buch.-ham	buch.-ham	ADJ
biomedich-495	262	10	)	)	PUNCT
biomedich-495	262	11	leaf	leaf	NOUN
biomedich-495	262	12	and	and	CCONJ
biomedich-495	262	13	root	root	NOUN
biomedich-495	262	14	extracts	extract	NOUN
biomedich-495	262	15	against	against	ADP
biomedich-495	262	16	clinically	clinically	ADV
biomedich-495	262	17	important	important	ADJ
biomedich-495	262	18	human	human	ADJ
biomedich-495	262	19	pathogens	pathogen	NOUN
biomedich-495	262	20	.	.	PUNCT
biomedich-495	263	1	biomedical	biomedical	PROPN
biomedich-495	263	2	&	&	CCONJ
biomedich-495	263	3	pharmacology	pharmacology	PROPN
biomedich-495	263	4	journal	journal	PROPN
biomedich-495	263	5	,	,	PUNCT
biomedich-495	263	6	6(2	6(2	NUM
biomedich-495	263	7	)	)	PUNCT
biomedich-495	263	8	,	,	PUNCT
biomedich-495	263	9	421–428	421–428	NUM
biomedich-495	263	10	.	.	PUNCT
biomedich-495	264	1	https://doi.org/10.13005/bpj/437	https://doi.org/10.13005/bpj/437	NOUN
biomedich-495	264	2	gentry	gentry	NOUN
biomedich-495	264	3	,	,	PUNCT
biomedich-495	264	4	a.	a.	PROPN
biomedich-495	264	5	c.	c.	PROPN
biomedich-495	264	6	,	,	PUNCT
biomedich-495	264	7	&	&	CCONJ
biomedich-495	264	8	osheroff	osheroff	PROPN
biomedich-495	264	9	,	,	PUNCT
biomedich-495	264	10	n.	n.	PROPN
biomedich-495	264	11	(	(	PUNCT
biomedich-495	264	12	2013	2013	NUM
biomedich-495	264	13	)	)	PUNCT
biomedich-495	264	14	.	.	PUNCT
biomedich-495	265	1	dna	dna	PROPN
biomedich-495	265	2	topoisomerases	topoisomerase	NOUN
biomedich-495	265	3	:	:	PUNCT
biomedich-495	265	4	type	type	PROPN
biomedich-495	265	5	ii	ii	PROPN
biomedich-495	265	6	.	.	PUNCT
biomedich-495	266	1	encyclopedia	encyclopedia	NOUN
biomedich-495	266	2	of	of	ADP
biomedich-495	266	3	biological	biological	ADJ
biomedich-495	266	4	chemistry	chemistry	NOUN
biomedich-495	266	5	:	:	PUNCT
biomedich-495	266	6	second	second	ADJ
biomedich-495	266	7	edition	edition	NOUN
biomedich-495	266	8	,	,	PUNCT
biomedich-495	266	9	163–168	163–168	NUM
biomedich-495	266	10	.	.	PUNCT
biomedich-495	267	1	https://doi.org/10.1016/b978-0-12-378630-2.002462	https://doi.org/10.1016/b978-0-12-378630-2.002462	PROPN
biomedich-495	267	2	hewawasam	hewawasam	PROPN
biomedich-495	267	3	,	,	PUNCT
biomedich-495	267	4	r.	r.	PROPN
biomedich-495	267	5	p.	p.	PROPN
biomedich-495	267	6	,	,	PUNCT
biomedich-495	267	7	jayatilaka	jayatilaka	PROPN
biomedich-495	267	8	,	,	PUNCT
biomedich-495	267	9	k.	k.	PROPN
biomedich-495	268	1	a.	a.	PROPN
biomedich-495	268	2	p.	p.	PROPN
biomedich-495	268	3	w.	w.	PROPN
biomedich-495	268	4	,	,	PUNCT
biomedich-495	268	5	pathirana	pathirana	PROPN
biomedich-495	268	6	,	,	PUNCT
biomedich-495	268	7	c.	c.	PROPN
biomedich-495	268	8	,	,	PUNCT
biomedich-495	268	9	&	&	CCONJ
biomedich-495	268	10	mudduwa	mudduwa	PROPN
biomedich-495	268	11	,	,	PUNCT
biomedich-495	268	12	l.	l.	PROPN
biomedich-495	268	13	k.	k.	PROPN
biomedich-495	268	14	b.	b.	PROPN
biomedich-495	268	15	(	(	PUNCT
biomedich-495	268	16	2003	2003	NUM
biomedich-495	268	17	)	)	PUNCT
biomedich-495	268	18	.	.	PUNCT
biomedich-495	269	1	protective	protective	ADJ
biomedich-495	269	2	effect	effect	NOUN
biomedich-495	269	3	of	of	ADP
biomedich-495	269	4	asteracantha	asteracantha	PROPN
biomedich-495	269	5	longifolia	longifolia	PROPN
biomedich-495	269	6	extract	extract	VERB
biomedich-495	269	7	in	in	ADP
biomedich-495	269	8	mouse	mouse	NOUN
biomedich-495	269	9	liver	liver	NOUN
biomedich-495	269	10	injury	injury	NOUN
biomedich-495	269	11	induced	induce	VERB
biomedich-495	269	12	by	by	ADP
biomedich-495	269	13	carbon	carbon	NOUN
biomedich-495	269	14	tetrachloride	tetrachloride	NOUN
biomedich-495	269	15	and	and	CCONJ
biomedich-495	269	16	paracetamol	paracetamol	NOUN
biomedich-495	269	17	.	.	PUNCT
biomedich-495	270	1	the	the	DET
biomedich-495	270	2	journal	journal	NOUN
biomedich-495	270	3	of	of	ADP
biomedich-495	270	4	pharmacy	pharmacy	NOUN
biomedich-495	270	5	and	and	CCONJ
biomedich-495	270	6	pharmacology	pharmacology	NOUN
biomedich-495	270	7	,	,	PUNCT
biomedich-495	270	8	55(10	55(10	NUM
biomedich-495	270	9	)	)	PUNCT
biomedich-495	270	10	,	,	PUNCT
biomedich-495	270	11	1413–1418	1413–1418	NUM
biomedich-495	270	12	.	.	PUNCT
biomedich-495	271	1	https://doi.org/10.1211/0022357021792	https://doi.org/10.1211/0022357021792	X
biomedich-495	271	2	kannur	kannur	PROPN
biomedich-495	271	3	,	,	PUNCT
biomedich-495	271	4	d.	d.	PROPN
biomedich-495	271	5	,	,	PUNCT
biomedich-495	271	6	paranjpe	paranjpe	PROPN
biomedich-495	271	7	,	,	PUNCT
biomedich-495	271	8	m.	m.	NOUN
biomedich-495	271	9	,	,	PUNCT
biomedich-495	271	10	dongre	dongre	NOUN
biomedich-495	271	11	,	,	PUNCT
biomedich-495	271	12	p.	p.	NOUN
biomedich-495	271	13	,	,	PUNCT
biomedich-495	271	14	kumbhar	kumbhar	PROPN
biomedich-495	271	15	,	,	PUNCT
biomedich-495	271	16	s.	s.	PROPN
biomedich-495	271	17	,	,	PUNCT
biomedich-495	271	18	&	&	CCONJ
biomedich-495	271	19	khandelwal	khandelwal	PROPN
biomedich-495	271	20	,	,	PUNCT
biomedich-495	271	21	k.	k.	PROPN
biomedich-495	271	22	(	(	PUNCT
biomedich-495	271	23	2012	2012	NUM
biomedich-495	271	24	)	)	PUNCT
biomedich-495	271	25	.	.	PUNCT
biomedich-495	272	1	anti	anti	ADJ
biomedich-495	272	2	-	-	ADJ
biomedich-495	272	3	inflammatory	inflammatory	ADJ
biomedich-495	272	4	and	and	CCONJ
biomedich-495	272	5	antinociceptive	antinociceptive	ADJ
biomedich-495	272	6	activities	activity	NOUN
biomedich-495	272	7	of	of	ADP
biomedich-495	272	8	h.	h.	PROPN
biomedich-495	272	9	schulli	schulli	PROPN
biomedich-495	272	10	seed	seed	NOUN
biomedich-495	272	11	extracts	extract	NOUN
biomedich-495	272	12	.	.	PUNCT
biomedich-495	273	1	international	international	ADJ
biomedich-495	273	2	journal	journal	NOUN
biomedich-495	273	3	of	of	ADP
biomedich-495	273	4	green	green	ADJ
biomedich-495	273	5	pharmacy	pharmacy	NOUN
biomedich-495	273	6	,	,	PUNCT
biomedich-495	273	7	6(3	6(3	NUM
biomedich-495	273	8	)	)	PUNCT
biomedich-495	273	9	,	,	PUNCT
biomedich-495	273	10	212	212	NUM
biomedich-495	273	11	.	.	PUNCT
biomedich-495	273	12	https://doi.org/10.4103/09738258.104934	https://doi.org/10.4103/09738258.104934	NOUN
biomedich-495	273	13	lawan	lawan	PROPN
biomedich-495	273	14	,	,	PUNCT
biomedich-495	273	15	h.	h.	PROPN
biomedich-495	273	16	,	,	PUNCT
biomedich-495	273	17	&	&	CCONJ
biomedich-495	273	18	tharakee	tharakee	PROPN
biomedich-495	273	19	,	,	PUNCT
biomedich-495	273	20	h.	h.	PROPN
biomedich-495	273	21	(	(	PUNCT
biomedich-495	273	22	2023	2023	NUM
biomedich-495	273	23	)	)	PUNCT
biomedich-495	273	24	.	.	PUNCT
biomedich-495	274	1	in	in	ADP
biomedich-495	274	2	silico	silico	NOUN
biomedich-495	274	3	study	study	NOUN
biomedich-495	274	4	on	on	ADP
biomedich-495	274	5	structural	structural	ADJ
biomedich-495	274	6	inhibition	inhibition	NOUN
biomedich-495	274	7	of	of	ADP
biomedich-495	274	8	bacterial	bacterial	ADJ
biomedich-495	274	9	dna	dna	NOUN
biomedich-495	274	10	gyrase	gyrase	NOUN
biomedich-495	274	11	by	by	ADP
biomedich-495	274	12	major	major	ADJ
biomedich-495	274	13	secondary	secondary	ADJ
biomedich-495	274	14	metabolites	metabolite	NOUN
biomedich-495	274	15	found	find	VERB
biomedich-495	274	16	in	in	ADP
biomedich-495	274	17	grape	grape	NOUN
biomedich-495	274	18	seed	seed	NOUN
biomedich-495	274	19	extract	extract	NOUN
biomedich-495	274	20	.	.	PUNCT
biomedich-495	275	1	biology	biology	NOUN
biomedich-495	275	2	,	,	PUNCT
biomedich-495	275	3	medicine	medicine	NOUN
biomedich-495	275	4	,	,	PUNCT
biomedich-495	275	5	&	&	CCONJ
biomedich-495	275	6	natural	natural	ADJ
biomedich-495	275	7	product	product	NOUN
biomedich-495	275	8	chemistry	chemistry	NOUN
biomedich-495	275	9	,	,	PUNCT
biomedich-495	275	10	12(2	12(2	NUM
biomedich-495	275	11	)	)	PUNCT
biomedich-495	275	12	,	,	PUNCT
biomedich-495	275	13	585–592	585–592	NUM
biomedich-495	275	14	.	.	PUNCT
biomedich-495	276	1	https://doi.org/10.14421/biomedich.2023.122.585-592	https://doi.org/10.14421/biomedich.2023.122.585-592	X
biomedich-495	276	2	lipinski	lipinski	PROPN
biomedich-495	276	3	,	,	PUNCT
biomedich-495	276	4	c.	c.	PROPN
biomedich-495	276	5	a.	a.	PROPN
biomedich-495	276	6	,	,	PUNCT
biomedich-495	276	7	lombardo	lombardo	PROPN
biomedich-495	276	8	,	,	PUNCT
biomedich-495	276	9	f.	f.	PROPN
biomedich-495	276	10	,	,	PUNCT
biomedich-495	276	11	dominy	dominy	PROPN
biomedich-495	276	12	,	,	PUNCT
biomedich-495	276	13	b.	b.	PROPN
biomedich-495	276	14	w.	w.	PROPN
biomedich-495	276	15	,	,	PUNCT
biomedich-495	276	16	&	&	CCONJ
biomedich-495	276	17	feeney	feeney	PROPN
biomedich-495	276	18	,	,	PUNCT
biomedich-495	276	19	p.	p.	PROPN
biomedich-495	276	20	j.	j.	PROPN
biomedich-495	276	21	(	(	PUNCT
biomedich-495	276	22	2001	2001	NUM
biomedich-495	276	23	)	)	PUNCT
biomedich-495	276	24	.	.	PUNCT
biomedich-495	277	1	experimental	experimental	ADJ
biomedich-495	277	2	and	and	CCONJ
biomedich-495	277	3	computational	computational	ADJ
biomedich-495	277	4	approaches	approach	NOUN
biomedich-495	277	5	to	to	PART
biomedich-495	277	6	estimate	estimate	VERB
biomedich-495	277	7	solubility	solubility	NOUN
biomedich-495	277	8	and	and	CCONJ
biomedich-495	277	9	permeability	permeability	NOUN
biomedich-495	277	10	in	in	ADP
biomedich-495	277	11	drug	drug	NOUN
biomedich-495	277	12	discovery	discovery	NOUN
biomedich-495	277	13	and	and	CCONJ
biomedich-495	277	14	development	development	NOUN
biomedich-495	277	15	settings	setting	NOUN
biomedich-495	277	16	.	.	PUNCT
biomedich-495	278	1	advanced	advanced	ADJ
biomedich-495	278	2	drug	drug	NOUN
biomedich-495	278	3	delivery	delivery	NOUN
biomedich-495	278	4	reviews	review	NOUN
biomedich-495	278	5	,	,	PUNCT
biomedich-495	278	6	46(1	46(1	NUM
biomedich-495	278	7	–	–	PUNCT
biomedich-495	278	8	3	3	NUM
biomedich-495	278	9	)	)	PUNCT
biomedich-495	278	10	,	,	PUNCT
biomedich-495	278	11	3–26	3–26	NUM
biomedich-495	278	12	.	.	PUNCT
biomedich-495	279	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
biomedich-495	279	2	mckie	mckie	PROPN
biomedich-495	279	3	,	,	PUNCT
biomedich-495	279	4	s.	s.	PROPN
biomedich-495	279	5	j.	j.	PROPN
biomedich-495	279	6	,	,	PUNCT
biomedich-495	279	7	neuman	neuman	PROPN
biomedich-495	279	8	,	,	PUNCT
biomedich-495	279	9	k.	k.	PROPN
biomedich-495	279	10	c.	c.	PROPN
biomedich-495	279	11	,	,	PUNCT
biomedich-495	279	12	&	&	CCONJ
biomedich-495	279	13	maxwell	maxwell	PROPN
biomedich-495	279	14	,	,	PUNCT
biomedich-495	279	15	a.	a.	NOUN
biomedich-495	279	16	(	(	PUNCT
biomedich-495	279	17	2021	2021	NUM
biomedich-495	279	18	)	)	PUNCT
biomedich-495	279	19	.	.	PUNCT
biomedich-495	280	1	dna	dna	PROPN
biomedich-495	280	2	topoisomerases	topoisomerase	NOUN
biomedich-495	280	3	:	:	PUNCT
biomedich-495	280	4	advances	advance	NOUN
biomedich-495	280	5	in	in	ADP
biomedich-495	280	6	understanding	understanding	NOUN
biomedich-495	280	7	of	of	ADP
biomedich-495	280	8	cellular	cellular	ADJ
biomedich-495	280	9	roles	role	NOUN
biomedich-495	280	10	and	and	CCONJ
biomedich-495	280	11	multi	multi	ADJ
biomedich-495	280	12	-	-	ADJ
biomedich-495	280	13	protein	protein	ADJ
biomedich-495	280	14	complexes	complex	NOUN
biomedich-495	280	15	via	via	ADP
biomedich-495	280	16	structure	structure	NOUN
biomedich-495	280	17	-	-	PUNCT
biomedich-495	280	18	function	function	NOUN
biomedich-495	280	19	analysis	analysis	NOUN
biomedich-495	280	20	.	.	PUNCT
biomedich-495	281	1	bioessays	bioessay	NOUN
biomedich-495	281	2	 	 	SPACE
biomedich-495	281	3	:	:	PUNCT
biomedich-495	281	4	news	news	NOUN
biomedich-495	281	5	and	and	CCONJ
biomedich-495	281	6	reviews	review	NOUN
biomedich-495	281	7	in	in	ADP
biomedich-495	281	8	molecular	molecular	ADJ
biomedich-495	281	9	,	,	PUNCT
biomedich-495	281	10	cellular	cellular	ADJ
biomedich-495	281	11	and	and	CCONJ
biomedich-495	281	12	developmental	developmental	ADJ
biomedich-495	281	13	biology	biology	NOUN
biomedich-495	281	14	,	,	PUNCT
biomedich-495	281	15	43(4	43(4	NOUN
biomedich-495	281	16	)	)	PUNCT
biomedich-495	281	17	,	,	PUNCT
biomedich-495	281	18	e2000286	e2000286	NOUN
biomedich-495	281	19	.	.	PUNCT
biomedich-495	281	20	https://doi.org/10.1002/bies.202000286	https://doi.org/10.1002/bies.202000286	PROPN
biomedich-495	281	21	molyneux	molyneux	PROPN
biomedich-495	281	22	,	,	PUNCT
biomedich-495	281	23	r.	r.	PROPN
biomedich-495	281	24	j.	j.	PROPN
biomedich-495	281	25	,	,	PUNCT
biomedich-495	281	26	lee	lee	PROPN
biomedich-495	281	27	,	,	PUNCT
biomedich-495	281	28	s.	s.	PROPN
biomedich-495	281	29	t.	t.	PROPN
biomedich-495	281	30	,	,	PUNCT
biomedich-495	281	31	gardner	gardner	PROPN
biomedich-495	281	32	,	,	PUNCT
biomedich-495	281	33	d.	d.	PROPN
biomedich-495	281	34	r.	r.	PROPN
biomedich-495	281	35	,	,	PUNCT
biomedich-495	281	36	panter	panter	PROPN
biomedich-495	281	37	,	,	PUNCT
biomedich-495	281	38	k.	k.	PROPN
biomedich-495	281	39	e.	e.	PROPN
biomedich-495	281	40	,	,	PUNCT
biomedich-495	281	41	&	&	CCONJ
biomedich-495	281	42	james	james	PROPN
biomedich-495	281	43	,	,	PUNCT
biomedich-495	281	44	l.	l.	PROPN
biomedich-495	281	45	f.	f.	PROPN
biomedich-495	281	46	(	(	PUNCT
biomedich-495	281	47	2007	2007	NUM
biomedich-495	281	48	)	)	PUNCT
biomedich-495	281	49	.	.	PUNCT
biomedich-495	282	1	phytochemicals	phytochemical	NOUN
biomedich-495	282	2	:	:	PUNCT
biomedich-495	282	3	the	the	DET
biomedich-495	282	4	good	good	NOUN
biomedich-495	282	5	,	,	PUNCT
biomedich-495	282	6	the	the	DET
biomedich-495	282	7	bad	bad	ADJ
biomedich-495	282	8	and	and	CCONJ
biomedich-495	282	9	the	the	DET
biomedich-495	282	10	ugly	ugly	ADJ
biomedich-495	282	11	?	?	PUNCT
biomedich-495	283	1	phytochemistry	phytochemistry	NOUN
biomedich-495	283	2	,	,	PUNCT
biomedich-495	283	3	68(22–24	68(22–24	NUM
biomedich-495	283	4	)	)	PUNCT
biomedich-495	283	5	,	,	PUNCT
biomedich-495	283	6	2973–2985	2973–2985	NUM
biomedich-495	283	7	.	.	PUNCT
biomedich-495	284	1	https://doi.org/10.1016/j.phytochem.2007.09.004	https://doi.org/10.1016/j.phytochem.2007.09.004	PROPN
biomedich-495	284	2	nissanka	nissanka	PROPN
biomedich-495	284	3	,	,	PUNCT
biomedich-495	284	4	m.	m.	PROPN
biomedich-495	284	5	c.	c.	PROPN
biomedich-495	284	6	,	,	PUNCT
biomedich-495	284	7	weerasekera	weerasekera	NOUN
biomedich-495	284	8	,	,	PUNCT
biomedich-495	284	9	m.	m.	NOUN
biomedich-495	284	10	m.	m.	PROPN
biomedich-495	284	11	,	,	PUNCT
biomedich-495	284	12	dilhari	dilhari	PROPN
biomedich-495	284	13	,	,	PUNCT
biomedich-495	284	14	a.	a.	PROPN
biomedich-495	284	15	,	,	PUNCT
biomedich-495	284	16	dissanayaka	dissanayaka	PROPN
biomedich-495	284	17	,	,	PUNCT
biomedich-495	284	18	r.	r.	PROPN
biomedich-495	284	19	,	,	PUNCT
biomedich-495	284	20	rathnayake	rathnayake	NOUN
biomedich-495	284	21	,	,	PUNCT
biomedich-495	284	22	s.	s.	PROPN
biomedich-495	284	23	,	,	PUNCT
biomedich-495	284	24	&	&	CCONJ
biomedich-495	284	25	wijesinghe	wijesinghe	ADJ
biomedich-495	284	26	,	,	PUNCT
biomedich-495	284	27	g.	g.	PROPN
biomedich-495	284	28	k.	k.	PROPN
biomedich-495	284	29	(	(	PUNCT
biomedich-495	284	30	2023	2023	NUM
biomedich-495	284	31	)	)	PUNCT
biomedich-495	284	32	.	.	PUNCT
biomedich-495	285	1	phytomedicinal	phytomedicinal	ADJ
biomedich-495	285	2	properties	property	NOUN
biomedich-495	285	3	of	of	ADP
biomedich-495	285	4	hygrophila	hygrophila	PROPN
biomedich-495	285	5	schulli	schulli	PROPN
biomedich-495	285	6	(	(	PUNCT
biomedich-495	285	7	neeramulliya	neeramulliya	PROPN
biomedich-495	285	8	)	)	PUNCT
biomedich-495	285	9	.	.	PUNCT
biomedich-495	286	1	iranian	iranian	PROPN
biomedich-495	286	2	journal	journal	PROPN
biomedich-495	286	3	of	of	ADP
biomedich-495	286	4	basic	basic	ADJ
biomedich-495	286	5	medical	medical	ADJ
biomedich-495	286	6	sciences	science	NOUN
biomedich-495	286	7	,	,	PUNCT
biomedich-495	286	8	26(9	26(9	NUM
biomedich-495	286	9	)	)	PUNCT
biomedich-495	286	10	,	,	PUNCT
biomedich-495	286	11	979–986	979–986	NUM
biomedich-495	286	12	.	.	PUNCT
biomedich-495	287	1	https://doi.org/10.22038/ijbms.2023.67965.14877	https://doi.org/10.22038/ijbms.2023.67965.14877	NOUN
biomedich-495	287	2	schoeffler	schoeffler	NOUN
biomedich-495	287	3	,	,	PUNCT
biomedich-495	287	4	a.	a.	PROPN
biomedich-495	287	5	j.	j.	PROPN
biomedich-495	287	6	,	,	PUNCT
biomedich-495	287	7	&	&	CCONJ
biomedich-495	287	8	berger	berger	PROPN
biomedich-495	287	9	,	,	PUNCT
biomedich-495	287	10	j.	j.	PROPN
biomedich-495	287	11	m.	m.	PROPN
biomedich-495	287	12	(	(	PUNCT
biomedich-495	287	13	2008	2008	NUM
biomedich-495	287	14	)	)	PUNCT
biomedich-495	287	15	.	.	PUNCT
biomedich-495	288	1	dna	dna	PROPN
biomedich-495	288	2	topoisomerases	topoisomerase	NOUN
biomedich-495	288	3	:	:	PUNCT
biomedich-495	288	4	harnessing	harness	VERB
biomedich-495	288	5	and	and	CCONJ
biomedich-495	288	6	constraining	constrain	VERB
biomedich-495	288	7	energy	energy	NOUN
biomedich-495	288	8	to	to	PART
biomedich-495	288	9	govern	govern	VERB
biomedich-495	288	10	chromosome	chromosome	NOUN
biomedich-495	288	11	topology	topology	NOUN
biomedich-495	288	12	.	.	PUNCT
biomedich-495	289	1	quarterly	quarterly	ADJ
biomedich-495	289	2	reviews	review	NOUN
biomedich-495	289	3	of	of	ADP
biomedich-495	289	4	biophysics	biophysic	NOUN
biomedich-495	289	5	,	,	PUNCT
biomedich-495	289	6	41(1	41(1	NUM
biomedich-495	289	7	)	)	PUNCT
biomedich-495	289	8	,	,	PUNCT
biomedich-495	289	9	41–101	41–101	PROPN
biomedich-495	289	10	.	.	PUNCT
biomedich-495	290	1	https://doi.org/10.1017/s003358350800468x	https://doi.org/10.1017/s003358350800468x	PROPN
biomedich-495	290	2	sethiya	sethiya	PROPN
biomedich-495	290	3	,	,	PUNCT
biomedich-495	290	4	n.	n.	PROPN
biomedich-495	290	5	k.	k.	PROPN
biomedich-495	290	6	,	,	PUNCT
biomedich-495	290	7	ahmed	ahmed	PROPN
biomedich-495	290	8	,	,	PUNCT
biomedich-495	290	9	n.	n.	PROPN
biomedich-495	290	10	m.	m.	NOUN
biomedich-495	290	11	,	,	PUNCT
biomedich-495	290	12	shekh	shekh	PROPN
biomedich-495	290	13	,	,	PUNCT
biomedich-495	290	14	r.	r.	PROPN
biomedich-495	290	15	m.	m.	PROPN
biomedich-495	290	16	,	,	PUNCT
biomedich-495	290	17	kumar	kumar	PROPN
biomedich-495	290	18	,	,	PUNCT
biomedich-495	290	19	v.	v.	PROPN
biomedich-495	290	20	,	,	PUNCT
biomedich-495	290	21	kumar	kumar	PROPN
biomedich-495	290	22	singh	singh	PROPN
biomedich-495	290	23	,	,	PUNCT
biomedich-495	290	24	p.	p.	PROPN
biomedich-495	290	25	,	,	PUNCT
biomedich-495	290	26	&	&	CCONJ
biomedich-495	290	27	kumar	kumar	PROPN
biomedich-495	290	28	,	,	PUNCT
biomedich-495	290	29	v.	v.	PROPN
biomedich-495	290	30	(	(	PUNCT
biomedich-495	290	31	2018	2018	NUM
biomedich-495	290	32	)	)	PUNCT
biomedich-495	290	33	.	.	PUNCT
biomedich-495	291	1	ethnomedicinal	ethnomedicinal	ADJ
biomedich-495	291	2	,	,	PUNCT
biomedich-495	291	3	phytochemical	phytochemical	ADJ
biomedich-495	291	4	and	and	CCONJ
biomedich-495	291	5	pharmacological	pharmacological	ADJ
biomedich-495	291	6	updates	update	NOUN
biomedich-495	291	7	on	on	ADP
biomedich-495	291	8	hygrophila	hygrophila	PROPN
biomedich-495	291	9	auriculata	auriculata	PROPN
biomedich-495	291	10	(	(	PUNCT
biomedich-495	291	11	schum	schum	PROPN
biomedich-495	291	12	.	.	PUNCT
biomedich-495	291	13	)	)	PUNCT
biomedich-495	292	1	hiene	hiene	NOUN
biomedich-495	292	2	:	:	PUNCT
biomedich-495	292	3	an	an	DET
biomedich-495	292	4	overview	overview	NOUN
biomedich-495	292	5	.	.	PUNCT
biomedich-495	293	1	journal	journal	NOUN
biomedich-495	293	2	of	of	ADP
biomedich-495	293	3	integrative	integrative	ADJ
biomedich-495	293	4	medicine	medicine	NOUN
biomedich-495	293	5	,	,	PUNCT
biomedich-495	293	6	16(5	16(5	NUM
biomedich-495	293	7	)	)	PUNCT
biomedich-495	293	8	,	,	PUNCT
biomedich-495	294	1	299–311	299–311	NUM
biomedich-495	294	2	.	.	PUNCT
biomedich-495	294	3	https://doi.org/10.1016/j.joim.2018.07.002	https://doi.org/10.1016/j.joim.2018.07.002	NOUN
biomedich-495	294	4	shoma	shoma	PROPN
biomedich-495	294	5	,	,	PUNCT
biomedich-495	294	6	f.	f.	PROPN
biomedich-495	294	7	(	(	PUNCT
biomedich-495	294	8	2018	2018	NUM
biomedich-495	294	9	)	)	PUNCT
biomedich-495	294	10	.	.	PUNCT
biomedich-495	295	1	phytochemical	phytochemical	ADJ
biomedich-495	295	2	screening	screening	NOUN
biomedich-495	295	3	and	and	CCONJ
biomedich-495	295	4	biological	biological	ADJ
biomedich-495	295	5	activity	activity	NOUN
biomedich-495	295	6	evaluation	evaluation	NOUN
biomedich-495	295	7	of	of	ADP
biomedich-495	295	8	hygrophila	hygrophila	PROPN
biomedich-495	295	9	schulli	schulli	PROPN
biomedich-495	295	10	.	.	PUNCT
biomedich-495	296	1	http://dspace.bracu.ac.bd/xmlui/handle/10361/10936	http://dspace.bracu.ac.bd/xmlui/handle/10361/10936	PROPN
biomedich-495	296	2	sutormin	sutormin	PROPN
biomedich-495	296	3	,	,	PUNCT
biomedich-495	296	4	d.	d.	PROPN
biomedich-495	296	5	a.	a.	PROPN
biomedich-495	296	6	,	,	PUNCT
biomedich-495	296	7	galivondzhyan	galivondzhyan	ADJ
biomedich-495	296	8	,	,	PUNCT
biomedich-495	296	9	a.	a.	PROPN
biomedich-495	296	10	k.	k.	PROPN
biomedich-495	296	11	,	,	PUNCT
biomedich-495	296	12	polkhovskiy	polkhovskiy	PROPN
biomedich-495	296	13	,	,	PUNCT
biomedich-495	296	14	a.	a.	NOUN
biomedich-495	296	15	v	v	PROPN
biomedich-495	296	16	,	,	PUNCT
biomedich-495	296	17	kamalyan	kamalyan	PROPN
biomedich-495	296	18	,	,	PUNCT
biomedich-495	296	19	s.	s.	PROPN
biomedich-495	296	20	o.	o.	PROPN
biomedich-495	296	21	,	,	PUNCT
biomedich-495	296	22	severinov	severinov	PROPN
biomedich-495	296	23	,	,	PUNCT
biomedich-495	296	24	k.	k.	PROPN
biomedich-495	296	25	v	v	PROPN
biomedich-495	296	26	,	,	PUNCT
biomedich-495	296	27	&	&	CCONJ
biomedich-495	296	28	dubiley	dubiley	PROPN
biomedich-495	296	29	,	,	PUNCT
biomedich-495	296	30	s.	s.	PROPN
biomedich-495	296	31	a.	a.	PROPN
biomedich-495	296	32	(	(	PUNCT
biomedich-495	296	33	2021	2021	NUM
biomedich-495	296	34	)	)	PUNCT
biomedich-495	296	35	.	.	PUNCT
biomedich-495	297	1	diversity	diversity	NOUN
biomedich-495	297	2	and	and	CCONJ
biomedich-495	297	3	functions	function	NOUN
biomedich-495	297	4	of	of	ADP
biomedich-495	297	5	type	type	NOUN
biomedich-495	297	6	ii	ii	NOUN
biomedich-495	297	7	topoisomerases	topoisomerase	NOUN
biomedich-495	297	8	.	.	PUNCT
biomedich-495	298	1	acta	acta	PROPN
biomedich-495	298	2	naturae	naturae	PROPN
biomedich-495	298	3	,	,	PUNCT
biomedich-495	298	4	13(1	13(1	NUM
biomedich-495	298	5	)	)	PUNCT
biomedich-495	298	6	,	,	PUNCT
biomedich-495	298	7	59–75	59–75	NUM
biomedich-495	298	8	.	.	PUNCT
biomedich-495	298	9	https://doi.org/10.32607/actanaturae.11058	https://doi.org/10.32607/actanaturae.11058	ADJ
biomedich-495	298	10	214	214	NUM
biomedich-495	298	11	biology	biology	NOUN
biomedich-495	298	12	,	,	PUNCT
biomedich-495	298	13	medicine	medicine	NOUN
biomedich-495	298	14	,	,	PUNCT
biomedich-495	298	15	&	&	CCONJ
biomedich-495	298	16	natural	natural	ADJ
biomedich-495	298	17	product	product	NOUN
biomedich-495	298	18	chemistry	chemistry	NOUN
biomedich-495	298	19	13	13	NUM
biomedich-495	298	20	(	(	PUNCT
biomedich-495	298	21	1	1	NUM
biomedich-495	298	22	)	)	PUNCT
biomedich-495	298	23	,	,	PUNCT
biomedich-495	298	24	2024	2024	NUM
biomedich-495	298	25	:	:	PUNCT
biomedich-495	298	26	205	205	NUM
biomedich-495	298	27	-	-	SYM
biomedich-495	298	28	214	214	NUM
biomedich-495	298	29	veber	veber	NOUN
biomedich-495	298	30	,	,	PUNCT
biomedich-495	298	31	d.	d.	PROPN
biomedich-495	298	32	f.	f.	PROPN
biomedich-495	298	33	,	,	PUNCT
biomedich-495	298	34	johnson	johnson	PROPN
biomedich-495	298	35	,	,	PUNCT
biomedich-495	298	36	s.	s.	PROPN
biomedich-495	298	37	r.	r.	PROPN
biomedich-495	298	38	,	,	PUNCT
biomedich-495	298	39	cheng	cheng	PROPN
biomedich-495	298	40	,	,	PUNCT
biomedich-495	298	41	h.-y	h.-y	NOUN
biomedich-495	298	42	.	.	PUNCT
biomedich-495	298	43	,	,	PUNCT
biomedich-495	298	44	smith	smith	PROPN
biomedich-495	298	45	,	,	PUNCT
biomedich-495	298	46	b.	b.	PROPN
biomedich-495	298	47	r.	r.	PROPN
biomedich-495	298	48	,	,	PUNCT
biomedich-495	298	49	ward	ward	PROPN
biomedich-495	298	50	,	,	PUNCT
biomedich-495	298	51	k.	k.	PROPN
biomedich-495	298	52	w.	w.	PROPN
biomedich-495	298	53	,	,	PUNCT
biomedich-495	298	54	&	&	CCONJ
biomedich-495	298	55	kopple	kopple	PROPN
biomedich-495	298	56	,	,	PUNCT
biomedich-495	298	57	k.	k.	PROPN
biomedich-495	298	58	d.	d.	PROPN
biomedich-495	298	59	(	(	PUNCT
biomedich-495	298	60	2002	2002	NUM
biomedich-495	298	61	)	)	PUNCT
biomedich-495	298	62	.	.	PUNCT
biomedich-495	299	1	molecular	molecular	ADJ
biomedich-495	299	2	properties	property	NOUN
biomedich-495	299	3	that	that	PRON
biomedich-495	299	4	influence	influence	VERB
biomedich-495	299	5	the	the	DET
biomedich-495	299	6	oral	oral	ADJ
biomedich-495	299	7	bioavailability	bioavailability	NOUN
biomedich-495	299	8	of	of	ADP
biomedich-495	299	9	drug	drug	NOUN
biomedich-495	299	10	candidates	candidate	NOUN
biomedich-495	299	11	.	.	PUNCT
biomedich-495	300	1	journal	journal	NOUN
biomedich-495	300	2	of	of	ADP
biomedich-495	300	3	medicinal	medicinal	ADJ
biomedich-495	300	4	chemistry	chemistry	NOUN
biomedich-495	300	5	,	,	PUNCT
biomedich-495	300	6	45(12	45(12	NUM
biomedich-495	300	7	)	)	PUNCT
biomedich-495	300	8	,	,	PUNCT
biomedich-495	300	9	2615–2623	2615–2623	NUM
biomedich-495	300	10	.	.	PUNCT
biomedich-495	301	1	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	PROPN
biomedich-495	301	2	yuan	yuan	PROPN
biomedich-495	301	3	,	,	PUNCT
biomedich-495	301	4	h.	h.	PROPN
biomedich-495	301	5	,	,	PUNCT
biomedich-495	301	6	ma	ma	PROPN
biomedich-495	301	7	,	,	PUNCT
biomedich-495	301	8	q.	q.	PROPN
biomedich-495	301	9	,	,	PUNCT
biomedich-495	301	10	ye	ye	PROPN
biomedich-495	301	11	,	,	PUNCT
biomedich-495	301	12	l.	l.	PROPN
biomedich-495	301	13	,	,	PUNCT
biomedich-495	301	14	&	&	CCONJ
biomedich-495	301	15	piao	piao	PROPN
biomedich-495	301	16	,	,	PUNCT
biomedich-495	301	17	g.	g.	PROPN
biomedich-495	301	18	(	(	PUNCT
biomedich-495	301	19	2016	2016	NUM
biomedich-495	301	20	)	)	PUNCT
biomedich-495	301	21	.	.	PUNCT
biomedich-495	302	1	the	the	DET
biomedich-495	302	2	traditional	traditional	ADJ
biomedich-495	302	3	medicine	medicine	NOUN
biomedich-495	302	4	and	and	CCONJ
biomedich-495	302	5	modern	modern	ADJ
biomedich-495	302	6	medicine	medicine	NOUN
biomedich-495	302	7	from	from	ADP
biomedich-495	302	8	natural	natural	ADJ
biomedich-495	302	9	products	product	NOUN
biomedich-495	302	10	.	.	PUNCT
biomedich-495	303	1	molecules	molecule	NOUN
biomedich-495	303	2	,	,	PUNCT
biomedich-495	303	3	21(5	21(5	NUM
biomedich-495	303	4	)	)	PUNCT
biomedich-495	303	5	,	,	PUNCT
biomedich-495	303	6	559	559	NUM
biomedich-495	303	7	.	.	PUNCT
biomedich-495	304	1	https://doi.org/10.3390/molecules21050559	https://doi.org/10.3390/molecules21050559	PROPN