id	sid	tid	token	lemma	pos
biomedich-541	1	1	biology	biology	NOUN
biomedich-541	1	2	,	,	PUNCT
biomedich-541	1	3	medicine	medicine	NOUN
biomedich-541	1	4	,	,	PUNCT
biomedich-541	1	5	&	&	CCONJ
biomedich-541	1	6	natural	natural	ADJ
biomedich-541	1	7	product	product	NOUN
biomedich-541	1	8	chemistry	chemistry	NOUN
biomedich-541	1	9	issn	issn	VERB
biomedich-541	1	10	2089	2089	NUM
biomedich-541	1	11	-	-	SYM
biomedich-541	1	12	6514	6514	NUM
biomedich-541	1	13	(	(	PUNCT
biomedich-541	1	14	paper	paper	NOUN
biomedich-541	1	15	)	)	PUNCT
biomedich-541	1	16	volume	volume	NOUN
biomedich-541	1	17	13	13	NUM
biomedich-541	1	18	,	,	PUNCT
biomedich-541	1	19	number	number	NOUN
biomedich-541	1	20	2	2	NUM
biomedich-541	1	21	,	,	PUNCT
biomedich-541	1	22	october	october	PROPN
biomedich-541	1	23	2024	2024	NUM
biomedich-541	1	24	|	|	ADV
biomedich-541	1	25	pages	page	NOUN
biomedich-541	1	26	:	:	PUNCT
biomedich-541	1	27	337	337	NUM
biomedich-541	1	28	-	-	SYM
biomedich-541	1	29	341	341	NUM
biomedich-541	1	30	|	|	ADV
biomedich-541	1	31	doi	doi	NOUN
biomedich-541	1	32	:	:	PUNCT
biomedich-541	1	33	10.14421	10.14421	NUM
biomedich-541	1	34	/	/	SYM
biomedich-541	1	35	biomedich.2024.132.337	biomedich.2024.132.337	PROPN
biomedich-541	1	36	-	-	PUNCT
biomedich-541	1	37	341	341	NUM
biomedich-541	1	38	issn	issn	PROPN
biomedich-541	1	39	2540	2540	NUM
biomedich-541	1	40	-	-	SYM
biomedich-541	1	41	9328	9328	NUM
biomedich-541	1	42	(	(	PUNCT
biomedich-541	1	43	online	online	ADJ
biomedich-541	1	44	)	)	PUNCT
biomedich-541	1	45	pharmacophore	pharmacophore	NOUN
biomedich-541	1	46	mapping	mapping	NOUN
biomedich-541	1	47	of	of	ADP
biomedich-541	1	48	angiotensin	angiotensin	NOUN
biomedich-541	1	49	converting	convert	VERB
biomedich-541	1	50	enzymes	enzyme	NOUN
biomedich-541	1	51	(	(	PUNCT
biomedich-541	1	52	aces	ace	NOUN
biomedich-541	1	53	):	):	PUNCT
biomedich-541	1	54	insight	insight	NOUN
biomedich-541	1	55	to	to	ADP
biomedich-541	1	56	binding	bind	VERB
biomedich-541	1	57	site	site	NOUN
biomedich-541	1	58	of	of	ADP
biomedich-541	1	59	ace1	ace1	PROPN
biomedich-541	1	60	and	and	CCONJ
biomedich-541	1	61	ace2	ace2	PROPN
biomedich-541	1	62	navista	navista	PROPN
biomedich-541	1	63	sri	sri	PROPN
biomedich-541	1	64	octa	octa	PROPN
biomedich-541	1	65	ujiantari	ujiantari	PROPN
biomedich-541	1	66	*	*	PROPN
biomedich-541	1	67	,	,	PUNCT
biomedich-541	1	68	cintya	cintya	PROPN
biomedich-541	1	69	nurul	nurul	PROPN
biomedich-541	1	70	apsari	apsari	PROPN
biomedich-541	1	71	laboratory	laboratory	NOUN
biomedich-541	1	72	of	of	ADP
biomedich-541	1	73	medicinal	medicinal	ADJ
biomedich-541	1	74	chemistry	chemistry	NOUN
biomedich-541	1	75	,	,	PUNCT
biomedich-541	1	76	departement	departement	NOUN
biomedich-541	1	77	of	of	ADP
biomedich-541	1	78	pharmaceutical	pharmaceutical	ADJ
biomedich-541	1	79	chemistry	chemistry	NOUN
biomedich-541	1	80	,	,	PUNCT
biomedich-541	1	81	faculty	faculty	NOUN
biomedich-541	1	82	of	of	ADP
biomedich-541	1	83	pharmacy	pharmacy	NOUN
biomedich-541	1	84	,	,	PUNCT
biomedich-541	1	85	universitas	universita	NOUN
biomedich-541	1	86	gadjah	gadjah	PROPN
biomedich-541	1	87	mada	mada	PROPN
biomedich-541	1	88	sekip	sekip	PROPN
biomedich-541	1	89	utara	utara	PROPN
biomedich-541	1	90	yogyakarta	yogyakarta	PROPN
biomedich-541	1	91	,	,	PUNCT
biomedich-541	1	92	55281	55281	NUM
biomedich-541	1	93	,	,	PUNCT
biomedich-541	1	94	indonesia	indonesia	PROPN
biomedich-541	1	95	.	.	PUNCT
biomedich-541	2	1	corresponding	correspond	VERB
biomedich-541	2	2	author	author	NOUN
biomedich-541	2	3	*	*	PROPN
biomedich-541	2	4	navista.sri.o@ugm.ac.id	navista.sri.o@ugm.ac.id	PROPN
biomedich-541	2	5	manuscript	manuscript	NOUN
biomedich-541	2	6	received	receive	VERB
biomedich-541	2	7	:	:	PUNCT
biomedich-541	2	8	11	11	NUM
biomedich-541	2	9	may	may	NOUN
biomedich-541	2	10	,	,	PUNCT
biomedich-541	2	11	2024	2024	NUM
biomedich-541	2	12	.	.	PUNCT
biomedich-541	3	1	revision	revision	NOUN
biomedich-541	3	2	accepted	accept	VERB
biomedich-541	3	3	:	:	PUNCT
biomedich-541	3	4	08	08	NUM
biomedich-541	3	5	august	august	PROPN
biomedich-541	3	6	,	,	PUNCT
biomedich-541	3	7	2024	2024	NUM
biomedich-541	3	8	.	.	PUNCT
biomedich-541	4	1	published	publish	VERB
biomedich-541	4	2	:	:	PUNCT
biomedich-541	4	3	01	01	NUM
biomedich-541	4	4	october	october	PROPN
biomedich-541	4	5	,	,	PUNCT
biomedich-541	4	6	2024	2024	NUM
biomedich-541	4	7	.	.	PUNCT
biomedich-541	5	1	abstract	abstract	ADJ
biomedich-541	5	2	angiotensin	angiotensin	NOUN
biomedich-541	5	3	converting	convert	VERB
biomedich-541	5	4	enzymes	enzyme	NOUN
biomedich-541	5	5	(	(	PUNCT
biomedich-541	5	6	aces	ace	NOUN
biomedich-541	5	7	)	)	PUNCT
biomedich-541	5	8	are	be	AUX
biomedich-541	5	9	carboxypeptidase	carboxypeptidase	NOUN
biomedich-541	5	10	enzymes	enzyme	NOUN
biomedich-541	5	11	involved	involve	VERB
biomedich-541	5	12	in	in	ADP
biomedich-541	5	13	the	the	DET
biomedich-541	5	14	renin	renin	ADJ
biomedich-541	5	15	-	-	PUNCT
biomedich-541	5	16	angiotensin	angiotensin	NOUN
biomedich-541	5	17	system	system	NOUN
biomedich-541	5	18	(	(	PUNCT
biomedich-541	5	19	ras	ras	NOUN
biomedich-541	5	20	)	)	PUNCT
biomedich-541	5	21	,	,	PUNCT
biomedich-541	5	22	which	which	DET
biomedich-541	5	23	catalyze	catalyze	NOUN
biomedich-541	5	24	angiotensin	angiotensin	VERB
biomedich-541	5	25	i	i	PRON
biomedich-541	5	26	by	by	ADP
biomedich-541	5	27	cleavage	cleavage	NOUN
biomedich-541	5	28	of	of	ADP
biomedich-541	5	29	the	the	DET
biomedich-541	5	30	peptide	peptide	NOUN
biomedich-541	5	31	bond	bond	NOUN
biomedich-541	5	32	.	.	PUNCT
biomedich-541	6	1	ace1	ace1	PROPN
biomedich-541	6	2	has	have	AUX
biomedich-541	6	3	been	be	AUX
biomedich-541	6	4	known	know	VERB
biomedich-541	6	5	as	as	ADP
biomedich-541	6	6	a	a	DET
biomedich-541	6	7	target	target	NOUN
biomedich-541	6	8	for	for	ADP
biomedich-541	6	9	antihypertensive	antihypertensive	ADJ
biomedich-541	6	10	drugs	drug	NOUN
biomedich-541	6	11	.	.	PUNCT
biomedich-541	7	1	another	another	DET
biomedich-541	7	2	homolog	homolog	NOUN
biomedich-541	7	3	of	of	ADP
biomedich-541	7	4	ace1	ace1	PROPN
biomedich-541	7	5	,	,	PUNCT
biomedich-541	7	6	ace2	ace2	PROPN
biomedich-541	7	7	has	have	AUX
biomedich-541	7	8	been	be	AUX
biomedich-541	7	9	popular	popular	ADJ
biomedich-541	7	10	since	since	SCONJ
biomedich-541	7	11	2020	2020	NUM
biomedich-541	7	12	because	because	SCONJ
biomedich-541	7	13	this	this	DET
biomedich-541	7	14	enzyme	enzyme	NOUN
biomedich-541	7	15	is	be	AUX
biomedich-541	7	16	responsible	responsible	ADJ
biomedich-541	7	17	for	for	ADP
biomedich-541	7	18	the	the	DET
biomedich-541	7	19	sars	sar	NOUN
biomedich-541	7	20	-	-	PUNCT
biomedich-541	7	21	cov2	cov2	PROPN
biomedich-541	7	22	infection	infection	NOUN
biomedich-541	7	23	in	in	ADP
biomedich-541	7	24	the	the	DET
biomedich-541	7	25	human	human	ADJ
biomedich-541	7	26	body	body	NOUN
biomedich-541	7	27	.	.	PUNCT
biomedich-541	8	1	interestingly	interestingly	ADV
biomedich-541	8	2	,	,	PUNCT
biomedich-541	8	3	it	it	PRON
biomedich-541	8	4	was	be	AUX
biomedich-541	8	5	found	find	VERB
biomedich-541	8	6	that	that	SCONJ
biomedich-541	8	7	ace1	ace1	PROPN
biomedich-541	8	8	inhibitors	inhibitor	NOUN
biomedich-541	8	9	did	do	AUX
biomedich-541	8	10	not	not	PART
biomedich-541	8	11	inhibit	inhibit	VERB
biomedich-541	8	12	ace2	ace2	NOUN
biomedich-541	8	13	.	.	PUNCT
biomedich-541	9	1	hence	hence	ADV
biomedich-541	9	2	,	,	PUNCT
biomedich-541	9	3	this	this	DET
biomedich-541	9	4	study	study	NOUN
biomedich-541	9	5	aims	aim	VERB
biomedich-541	9	6	to	to	PART
biomedich-541	9	7	elucidate	elucidate	VERB
biomedich-541	9	8	the	the	DET
biomedich-541	9	9	pharmacophore	pharmacophore	NOUN
biomedich-541	9	10	of	of	ADP
biomedich-541	9	11	ace1	ace1	PROPN
biomedich-541	9	12	and	and	CCONJ
biomedich-541	9	13	ace2	ace2	PROPN
biomedich-541	9	14	in	in	ADP
biomedich-541	9	15	order	order	NOUN
biomedich-541	9	16	to	to	PART
biomedich-541	9	17	understand	understand	VERB
biomedich-541	9	18	the	the	DET
biomedich-541	9	19	mechanism	mechanism	NOUN
biomedich-541	9	20	of	of	ADP
biomedich-541	9	21	these	these	DET
biomedich-541	9	22	different	different	ADJ
biomedich-541	9	23	inhibitions	inhibition	NOUN
biomedich-541	9	24	.	.	PUNCT
biomedich-541	10	1	pharmacophore	pharmacophore	ADJ
biomedich-541	10	2	mapping	mapping	NOUN
biomedich-541	10	3	was	be	AUX
biomedich-541	10	4	carried	carry	VERB
biomedich-541	10	5	out	out	ADP
biomedich-541	10	6	using	use	VERB
biomedich-541	10	7	a	a	DET
biomedich-541	10	8	pharmacophore	pharmacophore	ADJ
biomedich-541	10	9	query	query	NOUN
biomedich-541	10	10	editor	editor	NOUN
biomedich-541	10	11	in	in	ADP
biomedich-541	10	12	the	the	DET
biomedich-541	10	13	molecular	molecular	ADJ
biomedich-541	10	14	operating	operating	NOUN
biomedich-541	10	15	environment	environment	NOUN
biomedich-541	10	16	(	(	PUNCT
biomedich-541	10	17	moe	moe	NOUN
biomedich-541	10	18	)	)	PUNCT
biomedich-541	10	19	.	.	PUNCT
biomedich-541	11	1	the	the	DET
biomedich-541	11	2	3d	3d	PROPN
biomedich-541	11	3	structures	structure	NOUN
biomedich-541	11	4	of	of	ADP
biomedich-541	11	5	both	both	DET
biomedich-541	11	6	enzymes	enzyme	NOUN
biomedich-541	11	7	bound	bind	VERB
biomedich-541	11	8	to	to	ADP
biomedich-541	11	9	respective	respective	ADJ
biomedich-541	11	10	inhibitors	inhibitor	NOUN
biomedich-541	11	11	were	be	AUX
biomedich-541	11	12	prepared	prepare	VERB
biomedich-541	11	13	and	and	CCONJ
biomedich-541	11	14	their	their	PRON
biomedich-541	11	15	pharmacophore	pharmacophore	NOUN
biomedich-541	11	16	features	feature	NOUN
biomedich-541	11	17	were	be	AUX
biomedich-541	11	18	extracted	extract	VERB
biomedich-541	11	19	.	.	PUNCT
biomedich-541	12	1	besides	besides	SCONJ
biomedich-541	12	2	that	that	PRON
biomedich-541	12	3	,	,	PUNCT
biomedich-541	12	4	the	the	DET
biomedich-541	12	5	similarity	similarity	NOUN
biomedich-541	12	6	of	of	ADP
biomedich-541	12	7	both	both	DET
biomedich-541	12	8	enzymes	enzyme	NOUN
biomedich-541	12	9	was	be	AUX
biomedich-541	12	10	analyzed	analyze	VERB
biomedich-541	12	11	by	by	ADP
biomedich-541	12	12	comparing	compare	VERB
biomedich-541	12	13	their	their	PRON
biomedich-541	12	14	amino	amino	ADJ
biomedich-541	12	15	acid	acid	NOUN
biomedich-541	12	16	sequences	sequence	NOUN
biomedich-541	12	17	using	use	VERB
biomedich-541	12	18	align	align	NOUN
biomedich-541	12	19	in	in	ADP
biomedich-541	12	20	uniprot	uniprot	NOUN
biomedich-541	12	21	.	.	PUNCT
biomedich-541	13	1	in	in	ADP
biomedich-541	13	2	addition	addition	NOUN
biomedich-541	13	3	to	to	ADP
biomedich-541	13	4	pharmacophore	pharmacophore	NOUN
biomedich-541	13	5	mapping	mapping	NOUN
biomedich-541	13	6	,	,	PUNCT
biomedich-541	13	7	the	the	DET
biomedich-541	13	8	surfaces	surface	NOUN
biomedich-541	13	9	of	of	ADP
biomedich-541	13	10	both	both	DET
biomedich-541	13	11	binding	bind	VERB
biomedich-541	13	12	sites	site	NOUN
biomedich-541	13	13	were	be	AUX
biomedich-541	13	14	analyzed	analyze	VERB
biomedich-541	13	15	to	to	PART
biomedich-541	13	16	obtain	obtain	VERB
biomedich-541	13	17	a	a	DET
biomedich-541	13	18	comprehensive	comprehensive	ADJ
biomedich-541	13	19	evaluation	evaluation	NOUN
biomedich-541	13	20	.	.	PUNCT
biomedich-541	14	1	results	result	NOUN
biomedich-541	14	2	showed	show	VERB
biomedich-541	14	3	that	that	SCONJ
biomedich-541	14	4	both	both	CCONJ
biomedich-541	14	5	ace1	ace1	PROPN
biomedich-541	14	6	and	and	CCONJ
biomedich-541	14	7	ace2	ace2	PROPN
biomedich-541	14	8	contain	contain	VERB
biomedich-541	14	9	nine	nine	NUM
biomedich-541	14	10	and	and	CCONJ
biomedich-541	14	11	eight	eight	NUM
biomedich-541	14	12	pharmacophore	pharmacophore	NOUN
biomedich-541	14	13	features	feature	NOUN
biomedich-541	14	14	,	,	PUNCT
biomedich-541	14	15	respectively	respectively	ADV
biomedich-541	14	16	.	.	PUNCT
biomedich-541	15	1	the	the	DET
biomedich-541	15	2	amino	amino	NOUN
biomedich-541	15	3	acid	acid	NOUN
biomedich-541	15	4	residues	residue	NOUN
biomedich-541	15	5	of	of	ADP
biomedich-541	15	6	both	both	DET
biomedich-541	15	7	enzymes	enzyme	NOUN
biomedich-541	15	8	were	be	AUX
biomedich-541	15	9	quite	quite	ADV
biomedich-541	15	10	similar	similar	ADJ
biomedich-541	15	11	,	,	PUNCT
biomedich-541	15	12	especially	especially	ADV
biomedich-541	15	13	in	in	ADP
biomedich-541	15	14	the	the	DET
biomedich-541	15	15	active	active	ADJ
biomedich-541	15	16	site	site	NOUN
biomedich-541	15	17	.	.	PUNCT
biomedich-541	16	1	however	however	ADV
biomedich-541	16	2	,	,	PUNCT
biomedich-541	16	3	both	both	CCONJ
biomedich-541	16	4	ace1	ace1	PROPN
biomedich-541	16	5	and	and	CCONJ
biomedich-541	16	6	ace2	ace2	NOUN
biomedich-541	16	7	inhibitors	inhibitor	NOUN
biomedich-541	16	8	showed	show	VERB
biomedich-541	16	9	different	different	ADJ
biomedich-541	16	10	interactions	interaction	NOUN
biomedich-541	16	11	even	even	ADV
biomedich-541	16	12	though	though	SCONJ
biomedich-541	16	13	both	both	PRON
biomedich-541	16	14	were	be	AUX
biomedich-541	16	15	well	well	ADV
biomedich-541	16	16	aligned	align	VERB
biomedich-541	16	17	.	.	PUNCT
biomedich-541	17	1	it	it	PRON
biomedich-541	17	2	was	be	AUX
biomedich-541	17	3	found	find	VERB
biomedich-541	17	4	because	because	SCONJ
biomedich-541	17	5	the	the	DET
biomedich-541	17	6	functional	functional	ADJ
biomedich-541	17	7	groups	group	NOUN
biomedich-541	17	8	of	of	ADP
biomedich-541	17	9	both	both	DET
biomedich-541	17	10	inhibitors	inhibitor	NOUN
biomedich-541	17	11	were	be	AUX
biomedich-541	17	12	slightly	slightly	ADV
biomedich-541	17	13	different	different	ADJ
biomedich-541	17	14	as	as	ADV
biomedich-541	17	15	well	well	ADV
biomedich-541	17	16	as	as	ADP
biomedich-541	17	17	the	the	DET
biomedich-541	17	18	active	active	ADJ
biomedich-541	17	19	site	site	NOUN
biomedich-541	17	20	size	size	NOUN
biomedich-541	17	21	of	of	ADP
biomedich-541	17	22	both	both	DET
biomedich-541	17	23	enzymes	enzyme	NOUN
biomedich-541	17	24	.	.	PUNCT
biomedich-541	18	1	thus	thus	ADV
biomedich-541	18	2	,	,	PUNCT
biomedich-541	18	3	this	this	PRON
biomedich-541	18	4	might	might	AUX
biomedich-541	18	5	result	result	VERB
biomedich-541	18	6	in	in	ADP
biomedich-541	18	7	different	different	ADJ
biomedich-541	18	8	ability	ability	NOUN
biomedich-541	18	9	of	of	ADP
biomedich-541	18	10	ace1	ace1	NOUN
biomedich-541	18	11	inhibitors	inhibitor	NOUN
biomedich-541	18	12	to	to	PART
biomedich-541	18	13	occupy	occupy	VERB
biomedich-541	18	14	the	the	DET
biomedich-541	18	15	binding	bind	VERB
biomedich-541	18	16	site	site	NOUN
biomedich-541	18	17	of	of	ADP
biomedich-541	18	18	ace2	ace2	PROPN
biomedich-541	18	19	.	.	PUNCT
biomedich-541	19	1	these	these	DET
biomedich-541	19	2	findings	finding	NOUN
biomedich-541	19	3	could	could	AUX
biomedich-541	19	4	provide	provide	VERB
biomedich-541	19	5	useful	useful	ADJ
biomedich-541	19	6	information	information	NOUN
biomedich-541	19	7	in	in	ADP
biomedich-541	19	8	the	the	DET
biomedich-541	19	9	design	design	NOUN
biomedich-541	19	10	of	of	ADP
biomedich-541	19	11	new	new	ADJ
biomedich-541	19	12	selective	selective	ADJ
biomedich-541	19	13	ace1	ace1	NOUN
biomedich-541	19	14	compounds	compound	VERB
biomedich-541	19	15	as	as	ADV
biomedich-541	19	16	well	well	ADV
biomedich-541	19	17	as	as	ADP
biomedich-541	19	18	ace2	ace2	PROPN
biomedich-541	19	19	compounds	compound	NOUN
biomedich-541	19	20	.	.	PUNCT
biomedich-541	20	1	keywords	keyword	NOUN
biomedich-541	20	2	:	:	PUNCT
biomedich-541	20	3	pharmacophore	pharmacophore	NOUN
biomedich-541	20	4	mapping	mapping	NOUN
biomedich-541	20	5	;	;	PUNCT
biomedich-541	20	6	ace1	ace1	PROPN
biomedich-541	20	7	;	;	PUNCT
biomedich-541	20	8	ace2	ace2	PROPN
biomedich-541	20	9	;	;	PUNCT
biomedich-541	20	10	active	active	ADJ
biomedich-541	20	11	site	site	NOUN
biomedich-541	20	12	;	;	PUNCT
biomedich-541	20	13	homolog	homolog	NOUN
biomedich-541	20	14	protein	protein	NOUN
biomedich-541	20	15	.	.	PUNCT
biomedich-541	21	1	abbreviations	abbreviation	NOUN
biomedich-541	21	2	:	:	PUNCT
biomedich-541	21	3	ace	ace	NOUN
biomedich-541	21	4	:	:	PUNCT
biomedich-541	21	5	angiotensin	angiotensin	NOUN
biomedich-541	21	6	-	-	PUNCT
biomedich-541	21	7	converting	convert	VERB
biomedich-541	21	8	enzyme	enzyme	NOUN
biomedich-541	21	9	;	;	PUNCT
biomedich-541	21	10	moe	moe	NOUN
biomedich-541	21	11	:	:	PUNCT
biomedich-541	21	12	molecular	molecular	ADJ
biomedich-541	21	13	operating	operating	NOUN
biomedich-541	21	14	environment	environment	NOUN
biomedich-541	21	15	;	;	PUNCT
biomedich-541	21	16	ras	ra	VERB
biomedich-541	21	17	:	:	PUNCT
biomedich-541	21	18	renin	renin	ADJ
biomedich-541	21	19	-	-	PUNCT
biomedich-541	21	20	angiotensin	angiotensin	NOUN
biomedich-541	21	21	system	system	NOUN
biomedich-541	21	22	;	;	PUNCT
biomedich-541	21	23	acei	acei	NOUN
biomedich-541	21	24	:	:	PUNCT
biomedich-541	21	25	ace	ace	VERB
biomedich-541	21	26	inhibitor	inhibitor	NOUN
biomedich-541	21	27	;	;	PUNCT
biomedich-541	21	28	sars	sar	NOUN
biomedich-541	21	29	-	-	PUNCT
biomedich-541	21	30	cov-2	cov-2	NOUN
biomedich-541	21	31	:	:	PUNCT
biomedich-541	21	32	severe	severe	ADJ
biomedich-541	21	33	acute	acute	ADJ
biomedich-541	21	34	respiratory	respiratory	ADJ
biomedich-541	21	35	syndrome	syndrome	NOUN
biomedich-541	21	36	coronavirus	coronavirus	NOUN
biomedich-541	21	37	2	2	NUM
biomedich-541	21	38	.	.	PUNCT
biomedich-541	21	39	introduction	introduction	NOUN
biomedich-541	21	40	the	the	DET
biomedich-541	21	41	renin	renin	ADJ
biomedich-541	21	42	-	-	PUNCT
biomedich-541	21	43	angiotensin	angiotensin	NOUN
biomedich-541	21	44	system	system	NOUN
biomedich-541	21	45	(	(	PUNCT
biomedich-541	21	46	ras	ras	NOUN
biomedich-541	21	47	)	)	PUNCT
biomedich-541	21	48	plays	play	VERB
biomedich-541	21	49	a	a	DET
biomedich-541	21	50	role	role	NOUN
biomedich-541	21	51	in	in	ADP
biomedich-541	21	52	blood	blood	NOUN
biomedich-541	21	53	regulation	regulation	NOUN
biomedich-541	21	54	as	as	ADV
biomedich-541	21	55	well	well	ADV
biomedich-541	21	56	as	as	ADP
biomedich-541	21	57	glucose	glucose	NOUN
biomedich-541	21	58	metabolism	metabolism	NOUN
biomedich-541	21	59	,	,	PUNCT
biomedich-541	21	60	electrolyte	electrolyte	NOUN
biomedich-541	21	61	balance	balance	NOUN
biomedich-541	21	62	,	,	PUNCT
biomedich-541	21	63	and	and	CCONJ
biomedich-541	21	64	homeostasis	homeostasis	NOUN
biomedich-541	21	65	in	in	ADP
biomedich-541	21	66	the	the	DET
biomedich-541	21	67	body	body	NOUN
biomedich-541	21	68	.	.	PUNCT
biomedich-541	22	1	the	the	DET
biomedich-541	22	2	components	component	NOUN
biomedich-541	22	3	of	of	ADP
biomedich-541	22	4	this	this	DET
biomedich-541	22	5	system	system	NOUN
biomedich-541	22	6	include	include	VERB
biomedich-541	22	7	angiotensinogen	angiotensinogen	NOUN
biomedich-541	22	8	,	,	PUNCT
biomedich-541	22	9	angiotensin	angiotensin	NOUN
biomedich-541	22	10	i	i	PROPN
biomedich-541	22	11	,	,	PUNCT
biomedich-541	22	12	angiotensin	angiotensin	PROPN
biomedich-541	22	13	ii	ii	PROPN
biomedich-541	22	14	,	,	PUNCT
biomedich-541	22	15	angiotensin	angiotensin	NOUN
biomedich-541	22	16	-	-	PUNCT
biomedich-541	22	17	converting	convert	VERB
biomedich-541	22	18	enzyme	enzyme	NOUN
biomedich-541	22	19	(	(	PUNCT
biomedich-541	22	20	ace	ace	NOUN
biomedich-541	22	21	)	)	PUNCT
biomedich-541	22	22	(	(	PUNCT
biomedich-541	22	23	ahmad	ahmad	PROPN
biomedich-541	22	24	et	et	PROPN
biomedich-541	22	25	al	al	PROPN
biomedich-541	22	26	.	.	PROPN
biomedich-541	22	27	,	,	PUNCT
biomedich-541	22	28	2023	2023	NUM
biomedich-541	22	29	;	;	PUNCT
biomedich-541	22	30	alvarez	alvarez	PROPN
biomedich-541	22	31	-	-	PUNCT
biomedich-541	22	32	zaballos	zaballos	PROPN
biomedich-541	22	33	&	&	CCONJ
biomedich-541	22	34	martinez	martinez	PROPN
biomedich-541	22	35	-	-	PUNCT
biomedich-541	22	36	selles	selles	PROPN
biomedich-541	22	37	,	,	PUNCT
biomedich-541	22	38	2023	2023	NUM
biomedich-541	22	39	)	)	PUNCT
biomedich-541	22	40	.	.	PUNCT
biomedich-541	23	1	ace1	ace1	PROPN
biomedich-541	23	2	is	be	AUX
biomedich-541	23	3	a	a	DET
biomedich-541	23	4	carboxypeptidase	carboxypeptidase	NOUN
biomedich-541	23	5	that	that	PRON
biomedich-541	23	6	catalyzes	catalyze	VERB
biomedich-541	23	7	angiotensin	angiotensin	VERB
biomedich-541	23	8	i	i	PRON
biomedich-541	23	9	,	,	PUNCT
biomedich-541	23	10	a	a	DET
biomedich-541	23	11	decapeptide	decapeptide	NOUN
biomedich-541	23	12	by	by	ADP
biomedich-541	23	13	cleavage	cleavage	NOUN
biomedich-541	23	14	of	of	ADP
biomedich-541	23	15	the	the	DET
biomedich-541	23	16	peptide	peptide	NOUN
biomedich-541	23	17	bond	bond	NOUN
biomedich-541	23	18	into	into	ADP
biomedich-541	23	19	an	an	DET
biomedich-541	23	20	octapeptide	octapeptide	NOUN
biomedich-541	23	21	,	,	PUNCT
biomedich-541	23	22	angiotensin	angiotensin	NOUN
biomedich-541	23	23	ii	ii	PROPN
biomedich-541	23	24	(	(	PUNCT
biomedich-541	23	25	ames	ame	NOUN
biomedich-541	23	26	et	et	NOUN
biomedich-541	23	27	al	al	PROPN
biomedich-541	23	28	.	.	PROPN
biomedich-541	23	29	,	,	PUNCT
biomedich-541	23	30	2019	2019	NUM
biomedich-541	23	31	;	;	PUNCT
biomedich-541	23	32	ahmad	ahmad	PROPN
biomedich-541	23	33	et	et	PROPN
biomedich-541	23	34	al	al	PROPN
biomedich-541	23	35	.	.	PROPN
biomedich-541	23	36	,	,	PUNCT
biomedich-541	23	37	2023	2023	NUM
biomedich-541	23	38	)	)	PUNCT
biomedich-541	23	39	.	.	PUNCT
biomedich-541	24	1	this	this	DET
biomedich-541	24	2	enzyme	enzyme	NOUN
biomedich-541	24	3	has	have	AUX
biomedich-541	24	4	been	be	AUX
biomedich-541	24	5	known	know	VERB
biomedich-541	24	6	as	as	ADP
biomedich-541	24	7	antihypertensive	antihypertensive	ADJ
biomedich-541	24	8	drugs	drug	NOUN
biomedich-541	24	9	and	and	CCONJ
biomedich-541	24	10	the	the	DET
biomedich-541	24	11	synthetic	synthetic	ADJ
biomedich-541	24	12	drugs	drug	NOUN
biomedich-541	24	13	inhibit	inhibit	VERB
biomedich-541	24	14	this	this	DET
biomedich-541	24	15	enzyme	enzyme	NOUN
biomedich-541	24	16	namely	namely	ADV
biomedich-541	24	17	ace	ace	VERB
biomedich-541	24	18	inhibitor	inhibitor	NOUN
biomedich-541	24	19	(	(	PUNCT
biomedich-541	24	20	acei	acei	NOUN
biomedich-541	24	21	)	)	PUNCT
biomedich-541	24	22	(	(	PUNCT
biomedich-541	24	23	messerli	messerli	NOUN
biomedich-541	24	24	et	et	PROPN
biomedich-541	24	25	al	al	PROPN
biomedich-541	24	26	,	,	PUNCT
biomedich-541	24	27	2018	2018	NUM
biomedich-541	24	28	)	)	PUNCT
biomedich-541	24	29	.	.	PUNCT
biomedich-541	25	1	those	those	DET
biomedich-541	25	2	inhibitors	inhibitor	NOUN
biomedich-541	25	3	are	be	AUX
biomedich-541	25	4	orally	orally	ADV
biomedich-541	25	5	administered	administer	VERB
biomedich-541	25	6	and	and	CCONJ
biomedich-541	25	7	they	they	PRON
biomedich-541	25	8	usually	usually	ADV
biomedich-541	25	9	contain	contain	VERB
biomedich-541	25	10	the	the	DET
biomedich-541	25	11	suffix	suffix	ADJ
biomedich-541	25	12	“	"	PUNCT
biomedich-541	25	13	-pril	-pril	NOUN
biomedich-541	25	14	”	"	PUNCT
biomedich-541	25	15	in	in	ADP
biomedich-541	25	16	their	their	PRON
biomedich-541	25	17	name	name	NOUN
biomedich-541	25	18	,	,	PUNCT
biomedich-541	25	19	for	for	ADP
biomedich-541	25	20	instance	instance	NOUN
biomedich-541	25	21	captopril	captopril	NOUN
biomedich-541	25	22	,	,	PUNCT
biomedich-541	25	23	lisinopril	lisinopril	PROPN
biomedich-541	25	24	,	,	PUNCT
biomedich-541	25	25	fosinopril	fosinopril	ADJ
biomedich-541	25	26	,	,	PUNCT
biomedich-541	25	27	enalapril	enalapril	NOUN
biomedich-541	25	28	,	,	PUNCT
biomedich-541	25	29	and	and	CCONJ
biomedich-541	25	30	ramipril	ramipril	PROPN
biomedich-541	25	31	(	(	PUNCT
biomedich-541	25	32	ahmad	ahmad	PROPN
biomedich-541	25	33	et	et	PROPN
biomedich-541	25	34	al	al	PROPN
biomedich-541	25	35	.	.	PROPN
biomedich-541	25	36	,	,	PUNCT
biomedich-541	25	37	2023	2023	NUM
biomedich-541	25	38	)	)	PUNCT
biomedich-541	25	39	.	.	PUNCT
biomedich-541	26	1	pharmacophore	pharmacophore	NOUN
biomedich-541	26	2	modeling	modeling	NOUN
biomedich-541	26	3	has	have	AUX
biomedich-541	26	4	been	be	AUX
biomedich-541	26	5	applied	apply	VERB
biomedich-541	26	6	in	in	ADP
biomedich-541	26	7	drug	drug	NOUN
biomedich-541	26	8	design	design	NOUN
biomedich-541	26	9	and	and	CCONJ
biomedich-541	26	10	discovery	discovery	NOUN
biomedich-541	26	11	to	to	PART
biomedich-541	26	12	identify	identify	VERB
biomedich-541	26	13	compounds	compound	NOUN
biomedich-541	26	14	with	with	ADP
biomedich-541	26	15	specific	specific	ADJ
biomedich-541	26	16	biological	biological	ADJ
biomedich-541	26	17	activities	activity	NOUN
biomedich-541	26	18	and	and	CCONJ
biomedich-541	26	19	to	to	PART
biomedich-541	26	20	understand	understand	VERB
biomedich-541	26	21	their	their	PRON
biomedich-541	26	22	interaction	interaction	NOUN
biomedich-541	26	23	with	with	ADP
biomedich-541	26	24	protein	protein	NOUN
biomedich-541	26	25	or	or	CCONJ
biomedich-541	26	26	mapping	mapping	NOUN
biomedich-541	26	27	interaction	interaction	NOUN
biomedich-541	26	28	(	(	PUNCT
biomedich-541	26	29	seidel	seidel	PROPN
biomedich-541	26	30	et	et	PROPN
biomedich-541	26	31	al	al	PROPN
biomedich-541	26	32	.	.	PROPN
biomedich-541	26	33	,	,	PUNCT
biomedich-541	26	34	2018	2018	NUM
biomedich-541	26	35	)	)	PUNCT
biomedich-541	26	36	.	.	PUNCT
biomedich-541	27	1	the	the	DET
biomedich-541	27	2	functional	functional	ADJ
biomedich-541	27	3	groups	group	NOUN
biomedich-541	27	4	or	or	CCONJ
biomedich-541	27	5	parts	part	NOUN
biomedich-541	27	6	of	of	ADP
biomedich-541	27	7	molecules	molecule	NOUN
biomedich-541	27	8	responsible	responsible	ADJ
biomedich-541	27	9	for	for	ADP
biomedich-541	27	10	biological	biological	ADJ
biomedich-541	27	11	activities	activity	NOUN
biomedich-541	27	12	are	be	AUX
biomedich-541	27	13	called	call	VERB
biomedich-541	27	14	pharmacophores	pharmacophore	NOUN
biomedich-541	27	15	(	(	PUNCT
biomedich-541	27	16	güner	güner	PROPN
biomedich-541	27	17	dan	dan	PROPN
biomedich-541	27	18	bowen	bowen	PROPN
biomedich-541	27	19	,	,	PUNCT
biomedich-541	27	20	2014	2014	NUM
biomedich-541	27	21	)	)	PUNCT
biomedich-541	27	22	.	.	PUNCT
biomedich-541	28	1	the	the	DET
biomedich-541	28	2	pharmacophore	pharmacophore	NOUN
biomedich-541	28	3	features	feature	NOUN
biomedich-541	28	4	include	include	VERB
biomedich-541	28	5	hydrogen	hydrogen	NOUN
biomedich-541	28	6	bond	bond	NOUN
biomedich-541	28	7	acceptors	acceptor	NOUN
biomedich-541	28	8	and	and	CCONJ
biomedich-541	28	9	donors	donor	NOUN
biomedich-541	28	10	(	(	PUNCT
biomedich-541	28	11	hba	hba	PROPN
biomedich-541	28	12	dan	dan	PROPN
biomedich-541	28	13	hbd	hbd	PROPN
biomedich-541	28	14	)	)	PUNCT
biomedich-541	28	15	,	,	PUNCT
biomedich-541	28	16	ionized	ionized	ADJ
biomedich-541	28	17	groups	group	NOUN
biomedich-541	28	18	,	,	PUNCT
biomedich-541	28	19	hydrophobic	hydrophobic	NOUN
biomedich-541	28	20	(	(	PUNCT
biomedich-541	28	21	hy	hy	NOUN
biomedich-541	28	22	)	)	PUNCT
biomedich-541	28	23	,	,	PUNCT
biomedich-541	28	24	aromatic	aromatic	ADJ
biomedich-541	28	25	rings	ring	NOUN
biomedich-541	28	26	(	(	PUNCT
biomedich-541	28	27	ra	ra	NOUN
biomedich-541	28	28	)	)	PUNCT
biomedich-541	28	29	,	,	PUNCT
biomedich-541	28	30	metal	metal	NOUN
biomedich-541	28	31	coordination	coordination	NOUN
biomedich-541	28	32	(	(	PUNCT
biomedich-541	28	33	m	m	NOUN
biomedich-541	28	34	)	)	PUNCT
biomedich-541	28	35	,	,	PUNCT
biomedich-541	28	36	and	and	CCONJ
biomedich-541	28	37	halogen	halogen	PROPN
biomedich-541	28	38	bond	bond	NOUN
biomedich-541	28	39	(	(	PUNCT
biomedich-541	28	40	schaller	schaller	NOUN
biomedich-541	28	41	et	et	PROPN
biomedich-541	28	42	al	al	PROPN
biomedich-541	28	43	.	.	PROPN
biomedich-541	28	44	,	,	PUNCT
biomedich-541	28	45	2020	2020	NUM
biomedich-541	28	46	)	)	PUNCT
biomedich-541	28	47	.	.	PUNCT
biomedich-541	29	1	pharmacophore	pharmacophore	NOUN
biomedich-541	29	2	modeling	modeling	NOUN
biomedich-541	29	3	can	can	AUX
biomedich-541	29	4	be	be	AUX
biomedich-541	29	5	approached	approach	VERB
biomedich-541	29	6	in	in	ADP
biomedich-541	29	7	two	two	NUM
biomedich-541	29	8	ways	way	NOUN
biomedich-541	29	9	:	:	PUNCT
biomedich-541	29	10	ligand	ligand	NOUN
biomedich-541	29	11	-	-	PUNCT
biomedich-541	29	12	based	base	VERB
biomedich-541	29	13	and	and	CCONJ
biomedich-541	29	14	structurebased	structurebase	VERB
biomedich-541	29	15	(	(	PUNCT
biomedich-541	29	16	vuorinen	vuorinen	PROPN
biomedich-541	29	17	&	&	CCONJ
biomedich-541	29	18	schuster	schuster	PROPN
biomedich-541	29	19	,	,	PUNCT
biomedich-541	29	20	2015	2015	NUM
biomedich-541	29	21	)	)	PUNCT
biomedich-541	29	22	.	.	PUNCT
biomedich-541	30	1	ligand	ligand	NOUN
biomedich-541	30	2	-	-	PUNCT
biomedich-541	30	3	based	base	VERB
biomedich-541	30	4	pharmacophore	pharmacophore	NOUN
biomedich-541	30	5	modeling	modeling	NOUN
biomedich-541	30	6	relies	rely	VERB
biomedich-541	30	7	on	on	ADP
biomedich-541	30	8	known	know	VERB
biomedich-541	30	9	compound	compound	NOUN
biomedich-541	30	10	activities	activity	NOUN
biomedich-541	30	11	,	,	PUNCT
biomedich-541	30	12	whereas	whereas	SCONJ
biomedich-541	30	13	structure	structure	NOUN
biomedich-541	30	14	-	-	PUNCT
biomedich-541	30	15	based	base	VERB
biomedich-541	30	16	pharmacophore	pharmacophore	NOUN
biomedich-541	30	17	modeling	modeling	NOUN
biomedich-541	30	18	is	be	AUX
biomedich-541	30	19	derived	derive	VERB
biomedich-541	30	20	from	from	ADP
biomedich-541	30	21	3d	3d	NUM
biomedich-541	30	22	experimental	experimental	ADJ
biomedich-541	30	23	protein	protein	NOUN
biomedich-541	30	24	structures	structure	NOUN
biomedich-541	30	25	(	(	PUNCT
biomedich-541	30	26	seidel	seidel	PROPN
biomedich-541	30	27	et	et	PROPN
biomedich-541	30	28	al	al	PROPN
biomedich-541	30	29	.	.	PROPN
biomedich-541	30	30	,	,	PUNCT
biomedich-541	30	31	2018	2018	NUM
biomedich-541	30	32	)	)	PUNCT
biomedich-541	30	33	.	.	PUNCT
biomedich-541	31	1	the	the	DET
biomedich-541	31	2	3d	3d	PROPN
biomedich-541	31	3	structures	structure	NOUN
biomedich-541	31	4	provide	provide	VERB
biomedich-541	31	5	the	the	DET
biomedich-541	31	6	shape	shape	NOUN
biomedich-541	31	7	of	of	ADP
biomedich-541	31	8	active	active	ADJ
biomedich-541	31	9	site	site	NOUN
biomedich-541	31	10	as	as	ADV
biomedich-541	31	11	well	well	ADV
biomedich-541	31	12	as	as	ADP
biomedich-541	31	13	the	the	DET
biomedich-541	31	14	important	important	ADJ
biomedich-541	31	15	amino	amino	NOUN
biomedich-541	31	16	acid	acid	NOUN
biomedich-541	31	17	residues	residue	NOUN
biomedich-541	31	18	and	and	CCONJ
biomedich-541	31	19	the	the	DET
biomedich-541	31	20	type	type	NOUN
biomedich-541	31	21	interaction	interaction	NOUN
biomedich-541	31	22	(	(	PUNCT
biomedich-541	31	23	vuorinen	vuorinen	PROPN
biomedich-541	31	24	&	&	CCONJ
biomedich-541	31	25	schuster	schuster	PROPN
biomedich-541	31	26	,	,	PUNCT
biomedich-541	31	27	2015	2015	NUM
biomedich-541	31	28	)	)	PUNCT
biomedich-541	31	29	.	.	PUNCT
biomedich-541	32	1	in	in	ADP
biomedich-541	32	2	2019	2019	NUM
biomedich-541	32	3	,	,	PUNCT
biomedich-541	32	4	pneumonia	pneumonia	NOUN
biomedich-541	32	5	caused	cause	VERB
biomedich-541	32	6	by	by	ADP
biomedich-541	32	7	severe	severe	ADJ
biomedich-541	32	8	acute	acute	ADJ
biomedich-541	32	9	respiratory	respiratory	ADJ
biomedich-541	32	10	syndrome	syndrome	NOUN
biomedich-541	32	11	coronavirus	coronavirus	NOUN
biomedich-541	32	12	2	2	NUM
biomedich-541	32	13	(	(	PUNCT
biomedich-541	32	14	sars	sar	NOUN
biomedich-541	32	15	-	-	PUNCT
biomedich-541	32	16	cov-2	cov-2	NOUN
biomedich-541	32	17	)	)	PUNCT
biomedich-541	32	18	in	in	ADP
biomedich-541	32	19	https://doi.org/10.14421/biomedich.2024.132.337-341	https://doi.org/10.14421/biomedich.2024.132.337-341	ADP
biomedich-541	32	20	338	338	NUM
biomedich-541	32	21	biology	biology	NOUN
biomedich-541	32	22	,	,	PUNCT
biomedich-541	32	23	medicine	medicine	NOUN
biomedich-541	32	24	,	,	PUNCT
biomedich-541	32	25	&	&	CCONJ
biomedich-541	32	26	natural	natural	ADJ
biomedich-541	32	27	product	product	NOUN
biomedich-541	32	28	chemistry	chemistry	NOUN
biomedich-541	32	29	13	13	NUM
biomedich-541	32	30	(	(	PUNCT
biomedich-541	32	31	2	2	NUM
biomedich-541	32	32	)	)	PUNCT
biomedich-541	32	33	,	,	PUNCT
biomedich-541	32	34	2024	2024	NUM
biomedich-541	32	35	:	:	PUNCT
biomedich-541	32	36	337	337	NUM
biomedich-541	32	37	-	-	SYM
biomedich-541	32	38	341	341	NUM
biomedich-541	32	39	wuhan	wuhan	PROPN
biomedich-541	32	40	,	,	PUNCT
biomedich-541	32	41	china	china	PROPN
biomedich-541	32	42	,	,	PUNCT
biomedich-541	32	43	became	become	VERB
biomedich-541	32	44	a	a	DET
biomedich-541	32	45	global	global	ADJ
biomedich-541	32	46	pandemic	pandemic	NOUN
biomedich-541	32	47	(	(	PUNCT
biomedich-541	32	48	ni	ni	PROPN
biomedich-541	32	49	et	et	PROPN
biomedich-541	32	50	al	al	PROPN
biomedich-541	32	51	.	.	PROPN
biomedich-541	32	52	,	,	PUNCT
biomedich-541	32	53	2020	2020	NUM
biomedich-541	32	54	;	;	PUNCT
biomedich-541	32	55	ahmad	ahmad	PROPN
biomedich-541	32	56	et	et	PROPN
biomedich-541	32	57	al	al	PROPN
biomedich-541	32	58	.	.	PROPN
biomedich-541	32	59	,	,	PUNCT
biomedich-541	32	60	2021	2021	NUM
biomedich-541	32	61	)	)	PUNCT
biomedich-541	32	62	.	.	PUNCT
biomedich-541	33	1	the	the	DET
biomedich-541	33	2	virus	virus	NOUN
biomedich-541	33	3	can	can	AUX
biomedich-541	33	4	penetrate	penetrate	VERB
biomedich-541	33	5	the	the	DET
biomedich-541	33	6	human	human	ADJ
biomedich-541	33	7	body	body	NOUN
biomedich-541	33	8	through	through	ADP
biomedich-541	33	9	a	a	DET
biomedich-541	33	10	receptor	receptor	NOUN
biomedich-541	33	11	called	call	VERB
biomedich-541	33	12	ace2	ace2	PROPN
biomedich-541	33	13	(	(	PUNCT
biomedich-541	33	14	ahmad	ahmad	PROPN
biomedich-541	33	15	et	et	PROPN
biomedich-541	33	16	al	al	PROPN
biomedich-541	33	17	.	.	PROPN
biomedich-541	33	18	,	,	PUNCT
biomedich-541	33	19	2021	2021	NUM
biomedich-541	33	20	;	;	PUNCT
biomedich-541	33	21	pagliaro	pagliaro	NOUN
biomedich-541	33	22	et	et	PROPN
biomedich-541	33	23	al	al	PROPN
biomedich-541	33	24	.	.	PROPN
biomedich-541	33	25	,	,	PUNCT
biomedich-541	33	26	2022	2022	NUM
biomedich-541	33	27	)	)	PUNCT
biomedich-541	33	28	.	.	PUNCT
biomedich-541	34	1	this	this	DET
biomedich-541	34	2	enzyme	enzyme	NOUN
biomedich-541	34	3	catalyzes	catalyze	VERB
biomedich-541	34	4	angiotensin	angiotensin	NOUN
biomedich-541	34	5	ii	ii	PROPN
biomedich-541	34	6	into	into	ADP
biomedich-541	34	7	angiotensin	angiotensin	NOUN
biomedich-541	34	8	1	1	NUM
biomedich-541	34	9	-	-	SYM
biomedich-541	34	10	7	7	NUM
biomedich-541	34	11	and	and	CCONJ
biomedich-541	34	12	is	be	AUX
biomedich-541	34	13	expressed	express	VERB
biomedich-541	34	14	in	in	ADP
biomedich-541	34	15	several	several	ADJ
biomedich-541	34	16	organs	organ	NOUN
biomedich-541	34	17	such	such	ADJ
biomedich-541	34	18	as	as	ADP
biomedich-541	34	19	blood	blood	NOUN
biomedich-541	34	20	vessels	vessel	NOUN
biomedich-541	34	21	,	,	PUNCT
biomedich-541	34	22	the	the	DET
biomedich-541	34	23	brain	brain	NOUN
biomedich-541	34	24	,	,	PUNCT
biomedich-541	34	25	kidneys	kidney	NOUN
biomedich-541	34	26	,	,	PUNCT
biomedich-541	34	27	lungs	lung	NOUN
biomedich-541	34	28	,	,	PUNCT
biomedich-541	34	29	and	and	CCONJ
biomedich-541	34	30	the	the	DET
biomedich-541	34	31	digestive	digestive	ADJ
biomedich-541	34	32	system	system	NOUN
biomedich-541	34	33	(	(	PUNCT
biomedich-541	34	34	pagliaro	pagliaro	NOUN
biomedich-541	34	35	et	et	PROPN
biomedich-541	34	36	al	al	PROPN
biomedich-541	34	37	.	.	PROPN
biomedich-541	34	38	,	,	PUNCT
biomedich-541	34	39	2022	2022	NUM
biomedich-541	34	40	;	;	PUNCT
biomedich-541	34	41	dutta	dutta	NOUN
biomedich-541	34	42	,	,	PUNCT
biomedich-541	34	43	2022	2022	NUM
biomedich-541	34	44	)	)	PUNCT
biomedich-541	34	45	.	.	PUNCT
biomedich-541	35	1	although	although	SCONJ
biomedich-541	35	2	ace2	ace2	NOUN
biomedich-541	35	3	is	be	AUX
biomedich-541	35	4	a	a	DET
biomedich-541	35	5	homologous	homologous	ADJ
biomedich-541	35	6	protein	protein	NOUN
biomedich-541	35	7	with	with	ADP
biomedich-541	35	8	ace1	ace1	PROPN
biomedich-541	35	9	,	,	PUNCT
biomedich-541	35	10	ace1	ace1	PROPN
biomedich-541	35	11	inhibitors	inhibitor	NOUN
biomedich-541	35	12	do	do	AUX
biomedich-541	35	13	not	not	PART
biomedich-541	35	14	inhibit	inhibit	VERB
biomedich-541	35	15	ace2	ace2	NOUN
biomedich-541	35	16	activity	activity	NOUN
biomedich-541	35	17	(	(	PUNCT
biomedich-541	35	18	danser	danser	NOUN
biomedich-541	35	19	et	et	PROPN
biomedich-541	35	20	al	al	PROPN
biomedich-541	35	21	.	.	PROPN
biomedich-541	35	22	,	,	PUNCT
biomedich-541	35	23	2020	2020	NUM
biomedich-541	35	24	;	;	PUNCT
biomedich-541	35	25	kai	kai	PROPN
biomedich-541	35	26	&	&	CCONJ
biomedich-541	35	27	kai	kai	PROPN
biomedich-541	35	28	,	,	PUNCT
biomedich-541	35	29	2020	2020	NUM
biomedich-541	35	30	)	)	PUNCT
biomedich-541	35	31	.	.	PUNCT
biomedich-541	36	1	therefore	therefore	ADV
biomedich-541	36	2	,	,	PUNCT
biomedich-541	36	3	this	this	DET
biomedich-541	36	4	research	research	NOUN
biomedich-541	36	5	aims	aim	VERB
biomedich-541	36	6	to	to	PART
biomedich-541	36	7	examine	examine	VERB
biomedich-541	36	8	the	the	DET
biomedich-541	36	9	differences	difference	NOUN
biomedich-541	36	10	in	in	ADP
biomedich-541	36	11	the	the	DET
biomedich-541	36	12	active	active	ADJ
biomedich-541	36	13	sites	site	NOUN
biomedich-541	36	14	of	of	ADP
biomedich-541	36	15	ace1	ace1	PROPN
biomedich-541	36	16	and	and	CCONJ
biomedich-541	36	17	ace2	ace2	PROPN
biomedich-541	36	18	using	use	VERB
biomedich-541	36	19	structurebased	structurebase	VERB
biomedich-541	36	20	pharmacophore	pharmacophore	NOUN
biomedich-541	36	21	modeling	modeling	NOUN
biomedich-541	36	22	by	by	ADP
biomedich-541	36	23	mapping	map	VERB
biomedich-541	36	24	interactions	interaction	NOUN
biomedich-541	36	25	in	in	ADP
biomedich-541	36	26	both	both	DET
biomedich-541	36	27	enzymes	enzyme	NOUN
biomedich-541	36	28	.	.	PUNCT
biomedich-541	37	1	the	the	DET
biomedich-541	37	2	results	result	NOUN
biomedich-541	37	3	of	of	ADP
biomedich-541	37	4	this	this	DET
biomedich-541	37	5	study	study	NOUN
biomedich-541	37	6	can	can	AUX
biomedich-541	37	7	be	be	AUX
biomedich-541	37	8	used	use	VERB
biomedich-541	37	9	as	as	ADP
biomedich-541	37	10	valuable	valuable	ADJ
biomedich-541	37	11	information	information	NOUN
biomedich-541	37	12	,	,	PUNCT
biomedich-541	37	13	especially	especially	ADV
biomedich-541	37	14	in	in	ADP
biomedich-541	37	15	designing	design	VERB
biomedich-541	37	16	selective	selective	ADJ
biomedich-541	37	17	ace2	ace2	NOUN
biomedich-541	37	18	inhibitors	inhibitor	NOUN
biomedich-541	37	19	.	.	PUNCT
biomedich-541	38	1	materials	material	NOUN
biomedich-541	38	2	and	and	CCONJ
biomedich-541	38	3	methods	method	NOUN
biomedich-541	38	4	pharmacophore	pharmacophore	NOUN
biomedich-541	38	5	mapping	mapping	NOUN
biomedich-541	38	6	was	be	AUX
biomedich-541	38	7	conducted	conduct	VERB
biomedich-541	38	8	using	use	VERB
biomedich-541	38	9	the	the	DET
biomedich-541	38	10	pharmacophore	pharmacophore	ADJ
biomedich-541	38	11	query	query	NOUN
biomedich-541	38	12	editor	editor	NOUN
biomedich-541	38	13	in	in	ADP
biomedich-541	38	14	the	the	DET
biomedich-541	38	15	molecular	molecular	ADJ
biomedich-541	38	16	operating	operating	NOUN
biomedich-541	38	17	environment	environment	NOUN
biomedich-541	38	18	(	(	PUNCT
biomedich-541	38	19	moe	moe	NOUN
biomedich-541	38	20	,	,	PUNCT
biomedich-541	38	21	2022	2022	NUM
biomedich-541	38	22	)	)	PUNCT
biomedich-541	38	23	.	.	PUNCT
biomedich-541	39	1	the	the	DET
biomedich-541	39	2	3d	3d	PROPN
biomedich-541	39	3	structures	structure	NOUN
biomedich-541	39	4	of	of	ADP
biomedich-541	39	5	ace1	ace1	PROPN
biomedich-541	39	6	with	with	ADP
biomedich-541	39	7	pdb	pdb	PROPN
biomedich-541	39	8	i	i	PROPN
biomedich-541	39	9	d	d	PROPN
biomedich-541	39	10	:	:	PUNCT
biomedich-541	39	11	1o86	1o86	NUM
biomedich-541	39	12	(	(	PUNCT
biomedich-541	39	13	natesh	natesh	NOUN
biomedich-541	39	14	et	et	PROPN
biomedich-541	39	15	al	al	PROPN
biomedich-541	39	16	.	.	PROPN
biomedich-541	39	17	,	,	PUNCT
biomedich-541	39	18	2003	2003	NUM
biomedich-541	39	19	)	)	PUNCT
biomedich-541	39	20	;	;	PUNCT
biomedich-541	39	21	1uzf	1uzf	PROPN
biomedich-541	39	22	&	&	CCONJ
biomedich-541	39	23	1uze	1uze	PROPN
biomedich-541	39	24	(	(	PUNCT
biomedich-541	39	25	natesh	natesh	PROPN
biomedich-541	39	26	et	et	PROPN
biomedich-541	39	27	al	al	PROPN
biomedich-541	39	28	.	.	PROPN
biomedich-541	39	29	,	,	PUNCT
biomedich-541	39	30	2004	2004	NUM
biomedich-541	39	31	)	)	PUNCT
biomedich-541	39	32	,	,	PUNCT
biomedich-541	39	33	and	and	CCONJ
biomedich-541	39	34	ace2	ace2	NOUN
biomedich-541	39	35	with	with	ADP
biomedich-541	39	36	pdb	pdb	PROPN
biomedich-541	39	37	i	i	PROPN
biomedich-541	39	38	d	d	PROPN
biomedich-541	39	39	1r4l	1r4l	PROPN
biomedich-541	39	40	(	(	PUNCT
biomedich-541	39	41	towler	towler	NOUN
biomedich-541	39	42	et	et	PROPN
biomedich-541	39	43	al	al	PROPN
biomedich-541	39	44	.	.	PROPN
biomedich-541	39	45	,	,	PUNCT
biomedich-541	39	46	2004	2004	NUM
biomedich-541	39	47	)	)	PUNCT
biomedich-541	39	48	were	be	AUX
biomedich-541	39	49	obtained	obtain	VERB
biomedich-541	39	50	from	from	ADP
biomedich-541	39	51	the	the	DET
biomedich-541	39	52	protein	protein	NOUN
biomedich-541	39	53	data	datum	NOUN
biomedich-541	39	54	bank	bank	PROPN
biomedich-541	39	55	(	(	PUNCT
biomedich-541	39	56	burley	burley	PROPN
biomedich-541	39	57	et	et	PROPN
biomedich-541	39	58	al	al	PROPN
biomedich-541	39	59	.	.	PROPN
biomedich-541	39	60	,	,	PUNCT
biomedich-541	39	61	2017	2017	NUM
biomedich-541	39	62	)	)	PUNCT
biomedich-541	39	63	.	.	PUNCT
biomedich-541	40	1	all	all	PRON
biomedich-541	40	2	of	of	ADP
biomedich-541	40	3	those	those	DET
biomedich-541	40	4	enzymes	enzyme	NOUN
biomedich-541	40	5	are	be	AUX
biomedich-541	40	6	bound	bind	VERB
biomedich-541	40	7	to	to	ADP
biomedich-541	40	8	respective	respective	ADJ
biomedich-541	40	9	inhibitors	inhibitor	NOUN
biomedich-541	40	10	.	.	PUNCT
biomedich-541	41	1	the	the	DET
biomedich-541	41	2	enzymes	enzyme	NOUN
biomedich-541	41	3	were	be	AUX
biomedich-541	41	4	prepared	prepare	VERB
biomedich-541	41	5	,	,	PUNCT
biomedich-541	41	6	and	and	CCONJ
biomedich-541	41	7	their	their	PRON
biomedich-541	41	8	pharmacophore	pharmacophore	NOUN
biomedich-541	41	9	features	feature	NOUN
biomedich-541	41	10	were	be	AUX
biomedich-541	41	11	extracted	extract	VERB
biomedich-541	41	12	using	use	VERB
biomedich-541	41	13	the	the	DET
biomedich-541	41	14	pharmacophore	pharmacophore	ADJ
biomedich-541	41	15	query	query	NOUN
biomedich-541	41	16	editor	editor	NOUN
biomedich-541	41	17	.	.	PUNCT
biomedich-541	42	1	furthermore	furthermore	ADV
biomedich-541	42	2	,	,	PUNCT
biomedich-541	42	3	the	the	DET
biomedich-541	42	4	similarity	similarity	NOUN
biomedich-541	42	5	between	between	ADP
biomedich-541	42	6	the	the	DET
biomedich-541	42	7	two	two	NUM
biomedich-541	42	8	enzymes	enzyme	NOUN
biomedich-541	42	9	was	be	AUX
biomedich-541	42	10	analyzed	analyze	VERB
biomedich-541	42	11	by	by	ADP
biomedich-541	42	12	comparing	compare	VERB
biomedich-541	42	13	their	their	PRON
biomedich-541	42	14	amino	amino	ADJ
biomedich-541	42	15	acid	acid	NOUN
biomedich-541	42	16	sequences	sequence	NOUN
biomedich-541	42	17	using	use	VERB
biomedich-541	42	18	the	the	DET
biomedich-541	42	19	align	align	ADJ
biomedich-541	42	20	tool	tool	NOUN
biomedich-541	42	21	in	in	ADP
biomedich-541	42	22	uniprot	uniprot	ADJ
biomedich-541	42	23	(	(	PUNCT
biomedich-541	42	24	boutet	boutet	NOUN
biomedich-541	42	25	et	et	PROPN
biomedich-541	42	26	al	al	PROPN
biomedich-541	42	27	.	.	PROPN
biomedich-541	42	28	,	,	PUNCT
biomedich-541	42	29	2016	2016	NUM
biomedich-541	42	30	)	)	PUNCT
biomedich-541	42	31	.	.	PUNCT
biomedich-541	43	1	both	both	PRON
biomedich-541	43	2	2d	2d	NUM
biomedich-541	43	3	and	and	CCONJ
biomedich-541	43	4	3d	3d	NUM
biomedich-541	43	5	interactions	interaction	NOUN
biomedich-541	43	6	between	between	ADP
biomedich-541	43	7	the	the	DET
biomedich-541	43	8	inhibitor	inhibitor	NOUN
biomedich-541	43	9	and	and	CCONJ
biomedich-541	43	10	aces	ace	NOUN
biomedich-541	43	11	were	be	AUX
biomedich-541	43	12	visualized	visualize	VERB
biomedich-541	43	13	to	to	PART
biomedich-541	43	14	identify	identify	VERB
biomedich-541	43	15	the	the	DET
biomedich-541	43	16	types	type	NOUN
biomedich-541	43	17	of	of	ADP
biomedich-541	43	18	interactions	interaction	NOUN
biomedich-541	43	19	formed	form	VERB
biomedich-541	43	20	.	.	PUNCT
biomedich-541	44	1	additionally	additionally	ADV
biomedich-541	44	2	,	,	PUNCT
biomedich-541	44	3	the	the	DET
biomedich-541	44	4	active	active	ADJ
biomedich-541	44	5	site	site	NOUN
biomedich-541	44	6	surfaces	surface	NOUN
biomedich-541	44	7	of	of	ADP
biomedich-541	44	8	both	both	DET
biomedich-541	44	9	enzymes	enzyme	NOUN
biomedich-541	44	10	were	be	AUX
biomedich-541	44	11	analyzed	analyze	VERB
biomedich-541	44	12	to	to	PART
biomedich-541	44	13	obtain	obtain	VERB
biomedich-541	44	14	a	a	DET
biomedich-541	44	15	comprehensive	comprehensive	ADJ
biomedich-541	44	16	evaluation	evaluation	NOUN
biomedich-541	44	17	.	.	PUNCT
biomedich-541	45	1	results	result	NOUN
biomedich-541	45	2	and	and	CCONJ
biomedich-541	45	3	discussion	discussion	NOUN
biomedich-541	45	4	result	result	NOUN
biomedich-541	45	5	based	base	VERB
biomedich-541	45	6	on	on	ADP
biomedich-541	45	7	the	the	DET
biomedich-541	45	8	analysis	analysis	NOUN
biomedich-541	45	9	of	of	ADP
biomedich-541	45	10	amino	amino	NOUN
biomedich-541	45	11	acid	acid	NOUN
biomedich-541	45	12	sequence	sequence	NOUN
biomedich-541	45	13	similarity	similarity	NOUN
biomedich-541	45	14	using	use	VERB
biomedich-541	45	15	align	align	NOUN
biomedich-541	45	16	,	,	PUNCT
biomedich-541	45	17	the	the	DET
biomedich-541	45	18	results	result	NOUN
biomedich-541	45	19	indicated	indicate	VERB
biomedich-541	45	20	that	that	SCONJ
biomedich-541	45	21	ace1	ace1	PROPN
biomedich-541	45	22	and	and	CCONJ
biomedich-541	45	23	ace2	ace2	PROPN
biomedich-541	45	24	share	share	VERB
biomedich-541	45	25	36.61	36.61	NUM
biomedich-541	45	26	%	%	NOUN
biomedich-541	45	27	similarity	similarity	NOUN
biomedich-541	45	28	(	(	PUNCT
biomedich-541	45	29	per*cent	per*cent	NOUN
biomedich-541	45	30	identity	identity	NOUN
biomedich-541	45	31	)	)	PUNCT
biomedich-541	45	32	.	.	PUNCT
biomedich-541	46	1	homolog	homolog	PROPN
biomedich-541	46	2	proteins	protein	NOUN
biomedich-541	46	3	share	share	VERB
biomedich-541	46	4	30	30	NUM
biomedich-541	46	5	-	-	SYM
biomedich-541	46	6	40	40	NUM
biomedich-541	46	7	%	%	NOUN
biomedich-541	46	8	sequence	sequence	NOUN
biomedich-541	46	9	identity	identity	NOUN
biomedich-541	46	10	(	(	PUNCT
biomedich-541	46	11	cavasotto	cavasotto	NOUN
biomedich-541	46	12	&	&	CCONJ
biomedich-541	46	13	phatak	phatak	PROPN
biomedich-541	46	14	,	,	PUNCT
biomedich-541	46	15	2009	2009	NUM
biomedich-541	46	16	;	;	PUNCT
biomedich-541	46	17	pearson	pearson	PROPN
biomedich-541	46	18	,	,	PUNCT
biomedich-541	46	19	2013	2013	NUM
biomedich-541	46	20	)	)	PUNCT
biomedich-541	46	21	.	.	PUNCT
biomedich-541	47	1	figure	figure	NOUN
biomedich-541	47	2	1	1	NUM
biomedich-541	47	3	.	.	PUNCT
biomedich-541	48	1	the	the	DET
biomedich-541	48	2	alignment	alignment	NOUN
biomedich-541	48	3	of	of	ADP
biomedich-541	48	4	ace1	ace1	PROPN
biomedich-541	48	5	(	(	PUNCT
biomedich-541	48	6	green	green	ADJ
biomedich-541	48	7	)	)	PUNCT
biomedich-541	48	8	and	and	CCONJ
biomedich-541	48	9	ace2	ace2	PROPN
biomedich-541	48	10	(	(	PUNCT
biomedich-541	48	11	red	red	PROPN
biomedich-541	48	12	)	)	PUNCT
biomedich-541	48	13	along	along	ADP
biomedich-541	48	14	with	with	ADP
biomedich-541	48	15	their	their	PRON
biomedich-541	48	16	inhibitors	inhibitor	NOUN
biomedich-541	48	17	,	,	PUNCT
biomedich-541	48	18	namely	namely	ADV
biomedich-541	48	19	lisinopril	lisinopril	NOUN
biomedich-541	48	20	(	(	PUNCT
biomedich-541	48	21	green	green	ADJ
biomedich-541	48	22	)	)	PUNCT
biomedich-541	48	23	and	and	CCONJ
biomedich-541	48	24	mln-4760	mln-4760	NOUN
biomedich-541	48	25	(	(	PUNCT
biomedich-541	48	26	red	red	ADJ
biomedich-541	48	27	)	)	PUNCT
biomedich-541	48	28	,	,	PUNCT
biomedich-541	48	29	at	at	ADP
biomedich-541	48	30	the	the	DET
biomedich-541	48	31	active	active	ADJ
biomedich-541	48	32	site	site	NOUN
biomedich-541	48	33	of	of	ADP
biomedich-541	48	34	the	the	DET
biomedich-541	48	35	enzyme	enzyme	NOUN
biomedich-541	48	36	.	.	PUNCT
biomedich-541	49	1	figure	figure	NOUN
biomedich-541	49	2	2	2	NUM
biomedich-541	49	3	.	.	PUNCT
biomedich-541	50	1	pharmacophore	pharmacophore	NOUN
biomedich-541	50	2	features	feature	NOUN
biomedich-541	50	3	obtained	obtain	VERB
biomedich-541	50	4	from	from	ADP
biomedich-541	50	5	3d	3d	NUM
biomedich-541	50	6	structures	structure	NOUN
biomedich-541	50	7	of	of	ADP
biomedich-541	50	8	ace1	ace1	PROPN
biomedich-541	50	9	(	(	PUNCT
biomedich-541	50	10	a	a	NOUN
biomedich-541	50	11	)	)	PUNCT
biomedich-541	50	12	and	and	CCONJ
biomedich-541	50	13	ace2	ace2	PROPN
biomedich-541	50	14	(	(	PUNCT
biomedich-541	50	15	b	b	NOUN
biomedich-541	50	16	)	)	PUNCT
biomedich-541	50	17	.	.	PUNCT
biomedich-541	51	1	ujiantari	ujiantari	PROPN
biomedich-541	51	2	&	&	CCONJ
biomedich-541	51	3	apsari	apsari	PROPN
biomedich-541	51	4	–	–	PUNCT
biomedich-541	51	5	pharmacophore	pharmacophore	NOUN
biomedich-541	51	6	mapping	mapping	NOUN
biomedich-541	51	7	of	of	ADP
biomedich-541	51	8	ace1	ace1	PROPN
biomedich-541	51	9	and	and	CCONJ
biomedich-541	51	10	ace2	ace2	PROPN
biomedich-541	51	11	339	339	NUM
biomedich-541	51	12	in	in	ADP
biomedich-541	51	13	addition	addition	NOUN
biomedich-541	51	14	,	,	PUNCT
biomedich-541	51	15	the	the	DET
biomedich-541	51	16	alignment	alignment	NOUN
biomedich-541	51	17	results	result	NOUN
biomedich-541	51	18	of	of	ADP
biomedich-541	51	19	ace1	ace1	PROPN
biomedich-541	51	20	and	and	CCONJ
biomedich-541	51	21	ace2	ace2	PROPN
biomedich-541	51	22	(	(	PUNCT
biomedich-541	51	23	figure	figure	NOUN
biomedich-541	51	24	1	1	NUM
biomedich-541	51	25	)	)	PUNCT
biomedich-541	51	26	showed	show	VERB
biomedich-541	51	27	that	that	SCONJ
biomedich-541	51	28	ace1	ace1	PROPN
biomedich-541	51	29	and	and	CCONJ
biomedich-541	51	30	ace2	ace2	PROPN
biomedich-541	51	31	share	share	VERB
biomedich-541	51	32	similar	similar	ADJ
biomedich-541	51	33	protein	protein	NOUN
biomedich-541	51	34	backbone	backbone	NOUN
biomedich-541	51	35	or	or	CCONJ
biomedich-541	51	36	tertiary	tertiary	ADJ
biomedich-541	51	37	structure	structure	NOUN
biomedich-541	51	38	.	.	PUNCT
biomedich-541	52	1	figure	figure	NOUN
biomedich-541	52	2	1	1	NUM
biomedich-541	52	3	also	also	ADV
biomedich-541	52	4	depicted	depict	VERB
biomedich-541	52	5	that	that	SCONJ
biomedich-541	52	6	both	both	DET
biomedich-541	52	7	inhibitors	inhibitor	NOUN
biomedich-541	52	8	were	be	AUX
biomedich-541	52	9	well	well	ADV
biomedich-541	52	10	aligned	align	VERB
biomedich-541	52	11	in	in	ADP
biomedich-541	52	12	the	the	DET
biomedich-541	52	13	active	active	ADJ
biomedich-541	52	14	site	site	NOUN
biomedich-541	52	15	situated	situate	VERB
biomedich-541	52	16	in	in	ADP
biomedich-541	52	17	the	the	DET
biomedich-541	52	18	centre	centre	NOUN
biomedich-541	52	19	of	of	ADP
biomedich-541	52	20	both	both	DET
biomedich-541	52	21	enzymes	enzyme	NOUN
biomedich-541	52	22	.	.	PUNCT
biomedich-541	53	1	lisinopril	lisinopril	PROPN
biomedich-541	53	2	,	,	PUNCT
biomedich-541	53	3	an	an	DET
biomedich-541	53	4	ace1	ace1	NOUN
biomedich-541	53	5	inhibitor	inhibitor	NOUN
biomedich-541	53	6	,	,	PUNCT
biomedich-541	53	7	also	also	ADV
biomedich-541	53	8	closely	closely	ADV
biomedich-541	53	9	shared	share	VERB
biomedich-541	53	10	a	a	DET
biomedich-541	53	11	similar	similar	ADJ
biomedich-541	53	12	orientation	orientation	NOUN
biomedich-541	53	13	with	with	ADP
biomedich-541	53	14	mln-4760	mln-4760	NOUN
biomedich-541	53	15	,	,	PUNCT
biomedich-541	53	16	an	an	DET
biomedich-541	53	17	ace2	ace2	NOUN
biomedich-541	53	18	inhibitor	inhibitor	NOUN
biomedich-541	53	19	.	.	PUNCT
biomedich-541	54	1	pharmacophore	pharmacophore	ADJ
biomedich-541	54	2	mapping	mapping	NOUN
biomedich-541	54	3	was	be	AUX
biomedich-541	54	4	conducted	conduct	VERB
biomedich-541	54	5	to	to	PART
biomedich-541	54	6	identify	identify	VERB
biomedich-541	54	7	potential	potential	ADJ
biomedich-541	54	8	interactions	interaction	NOUN
biomedich-541	54	9	between	between	ADP
biomedich-541	54	10	the	the	DET
biomedich-541	54	11	inhibitors	inhibitor	NOUN
biomedich-541	54	12	and	and	CCONJ
biomedich-541	54	13	both	both	DET
biomedich-541	54	14	enzymes	enzyme	NOUN
biomedich-541	54	15	(	(	PUNCT
biomedich-541	54	16	figure	figure	NOUN
biomedich-541	54	17	2	2	NUM
biomedich-541	54	18	)	)	PUNCT
biomedich-541	54	19	.	.	PUNCT
biomedich-541	55	1	in	in	ADP
biomedich-541	55	2	figure	figure	NOUN
biomedich-541	55	3	2	2	NUM
biomedich-541	55	4	,	,	PUNCT
biomedich-541	55	5	ace1	ace1	PROPN
biomedich-541	55	6	exhibited	exhibit	VERB
biomedich-541	55	7	nine	nine	NUM
biomedich-541	55	8	pharmacophore	pharmacophore	NOUN
biomedich-541	55	9	features	feature	NOUN
biomedich-541	55	10	,	,	PUNCT
biomedich-541	55	11	including	include	VERB
biomedich-541	55	12	6	6	NUM
biomedich-541	55	13	hba	hba	NOUN
biomedich-541	55	14	,	,	PUNCT
biomedich-541	55	15	1	1	NUM
biomedich-541	55	16	hy	hy	NOUN
biomedich-541	55	17	,	,	PUNCT
biomedich-541	55	18	1	1	NUM
biomedich-541	55	19	ra	ra	NOUN
biomedich-541	55	20	,	,	PUNCT
biomedich-541	55	21	and	and	CCONJ
biomedich-541	55	22	1	1	NUM
biomedich-541	55	23	hbd	hbd	NOUN
biomedich-541	55	24	,	,	PUNCT
biomedich-541	55	25	while	while	SCONJ
biomedich-541	55	26	eight	eight	NUM
biomedich-541	55	27	pharmacophore	pharmacophore	NOUN
biomedich-541	55	28	features	feature	NOUN
biomedich-541	55	29	were	be	AUX
biomedich-541	55	30	extracted	extract	VERB
biomedich-541	55	31	from	from	ADP
biomedich-541	55	32	ace2	ace2	NOUN
biomedich-541	55	33	consisting	consist	VERB
biomedich-541	55	34	of	of	ADP
biomedich-541	55	35	4	4	NUM
biomedich-541	55	36	hba	hba	NOUN
biomedich-541	55	37	,	,	PUNCT
biomedich-541	55	38	3	3	NUM
biomedich-541	55	39	hy	hy	NOUN
biomedich-541	55	40	,	,	PUNCT
biomedich-541	55	41	and	and	CCONJ
biomedich-541	55	42	1	1	NUM
biomedich-541	55	43	hbd	hbd	NOUN
biomedich-541	55	44	.	.	PUNCT
biomedich-541	56	1	figure	figure	NOUN
biomedich-541	56	2	3	3	NUM
biomedich-541	56	3	.	.	PUNCT
biomedich-541	56	4	2d	2d	NUM
biomedich-541	56	5	interaction	interaction	NOUN
biomedich-541	56	6	of	of	ADP
biomedich-541	56	7	ace1	ace1	PROPN
biomedich-541	56	8	with	with	ADP
biomedich-541	56	9	lisinopril	lisinopril	PROPN
biomedich-541	56	10	(	(	PUNCT
biomedich-541	56	11	a	a	NOUN
biomedich-541	56	12	)	)	PUNCT
biomedich-541	56	13	,	,	PUNCT
biomedich-541	56	14	enalaprilat	enalaprilat	NOUN
biomedich-541	56	15	(	(	PUNCT
biomedich-541	56	16	b	b	NOUN
biomedich-541	56	17	)	)	PUNCT
biomedich-541	56	18	,	,	PUNCT
biomedich-541	56	19	captopril	captopril	NOUN
biomedich-541	56	20	(	(	PUNCT
biomedich-541	56	21	c	c	NOUN
biomedich-541	56	22	)	)	PUNCT
biomedich-541	56	23	,	,	PUNCT
biomedich-541	56	24	and	and	CCONJ
biomedich-541	56	25	ace2	ace2	NOUN
biomedich-541	56	26	with	with	ADP
biomedich-541	56	27	mln-4760	mln-4760	NOUN
biomedich-541	56	28	(	(	PUNCT
biomedich-541	56	29	d	d	NOUN
biomedich-541	56	30	)	)	PUNCT
biomedich-541	56	31	.	.	PUNCT
biomedich-541	57	1	table	table	NOUN
biomedich-541	57	2	1	1	NUM
biomedich-541	57	3	.	.	PUNCT
biomedich-541	58	1	the	the	DET
biomedich-541	58	2	amino	amino	NOUN
biomedich-541	58	3	acid	acid	NOUN
biomedich-541	58	4	residues	residue	NOUN
biomedich-541	58	5	in	in	ADP
biomedich-541	58	6	the	the	DET
biomedich-541	58	7	active	active	ADJ
biomedich-541	58	8	site	site	NOUN
biomedich-541	58	9	of	of	ADP
biomedich-541	58	10	both	both	DET
biomedich-541	58	11	enzymes	enzyme	NOUN
biomedich-541	58	12	and	and	CCONJ
biomedich-541	58	13	the	the	DET
biomedich-541	58	14	type	type	NOUN
biomedich-541	58	15	of	of	ADP
biomedich-541	58	16	interactions	interaction	NOUN
biomedich-541	58	17	.	.	PUNCT
biomedich-541	59	1	ace1	ace1	PROPN
biomedich-541	59	2	ace2	ace2	PROPN
biomedich-541	59	3	type	type	NOUN
biomedich-541	59	4	of	of	ADP
biomedich-541	59	5	interactions	interaction	NOUN
biomedich-541	59	6	his353	his353	PROPN
biomedich-541	59	7	his345	his345	PROPN
biomedich-541	59	8	hydrogen	hydrogen	NOUN
biomedich-541	59	9	bond	bond	NOUN
biomedich-541	59	10	ala354	ala354	PROPN
biomedich-541	59	11	pro346	pro346	VERB
biomedich-541	59	12	ser355	ser355	PROPN
biomedich-541	59	13	thr347	thr347	ADJ
biomedich-541	59	14	asp377	asp377	NOUN
biomedich-541	59	15	asp368	asp368	PROPN
biomedich-541	59	16	his383	his383	PROPN
biomedich-541	59	17	his374	his374	PROPN
biomedich-541	59	18	metal	metal	NOUN
biomedich-541	59	19	coordination	coordination	NOUN
biomedich-541	59	20	/	/	SYM
biomedich-541	59	21	complex	complex	NOUN
biomedich-541	59	22	with	with	ADP
biomedich-541	59	23	zn	zn	NOUN
biomedich-541	59	24	and	and	CCONJ
biomedich-541	59	25	inhibitor	inhibitor	NOUN
biomedich-541	59	26	glu384	glu384	PROPN
biomedich-541	59	27	glu375	glu375	PROPN
biomedich-541	59	28	his387	his387	PROPN
biomedich-541	59	29	his378	his378	PROPN
biomedich-541	59	30	hydrogen	hydrogen	NOUN
biomedich-541	59	31	bond	bond	NOUN
biomedich-541	59	32	glu411	glu411	PROPN
biomedich-541	59	33	glu402	glu402	PROPN
biomedich-541	59	34	metal	metal	NOUN
biomedich-541	59	35	coordination	coordination	NOUN
biomedich-541	59	36	/	/	SYM
biomedich-541	59	37	complex	complex	NOUN
biomedich-541	59	38	with	with	ADP
biomedich-541	59	39	zn	zn	NOUN
biomedich-541	59	40	and	and	CCONJ
biomedich-541	59	41	inhibitor	inhibitor	NOUN
biomedich-541	59	42	phe512	phe512	PROPN
biomedich-541	59	43	phe504	phe504	PROPN
biomedich-541	59	44	his513	his513	PROPN
biomedich-541	59	45	his505	his505	PROPN
biomedich-541	59	46	val518	val518	PROPN
biomedich-541	59	47	tyr510	tyr510	PROPN
biomedich-541	59	48	tyr523	tyr523	PROPN
biomedich-541	59	49	tyr515	tyr515	NOUN
biomedich-541	59	50	note	note	NOUN
biomedich-541	59	51	:	:	PUNCT
biomedich-541	59	52	bold	bold	ADJ
biomedich-541	59	53	line	line	NOUN
biomedich-541	59	54	means	mean	VERB
biomedich-541	59	55	same	same	ADJ
biomedich-541	59	56	amino	amino	NOUN
biomedich-541	59	57	acid	acid	NOUN
biomedich-541	59	58	residue	residue	NOUN
biomedich-541	59	59	the	the	DET
biomedich-541	59	60	2d	2d	NOUN
biomedich-541	59	61	visualization	visualization	NOUN
biomedich-541	59	62	between	between	ADP
biomedich-541	59	63	the	the	DET
biomedich-541	59	64	inhibitor	inhibitor	NOUN
biomedich-541	59	65	and	and	CCONJ
biomedich-541	59	66	the	the	DET
biomedich-541	59	67	enzyme	enzyme	NOUN
biomedich-541	59	68	was	be	AUX
biomedich-541	59	69	performed	perform	VERB
biomedich-541	59	70	to	to	PART
biomedich-541	59	71	identify	identify	VERB
biomedich-541	59	72	the	the	DET
biomedich-541	59	73	types	type	NOUN
biomedich-541	59	74	of	of	ADP
biomedich-541	59	75	interactions	interaction	NOUN
biomedich-541	59	76	.	.	PUNCT
biomedich-541	60	1	at	at	ADP
biomedich-541	60	2	the	the	DET
biomedich-541	60	3	active	active	ADJ
biomedich-541	60	4	sites	site	NOUN
biomedich-541	60	5	of	of	ADP
biomedich-541	60	6	both	both	DET
biomedich-541	60	7	enzymes	enzyme	NOUN
biomedich-541	60	8	,	,	PUNCT
biomedich-541	60	9	there	there	PRON
biomedich-541	60	10	are	be	VERB
biomedich-541	60	11	similarities	similarity	NOUN
biomedich-541	60	12	in	in	ADP
biomedich-541	60	13	several	several	ADJ
biomedich-541	60	14	amino	amino	NOUN
biomedich-541	60	15	acid	acid	NOUN
biomedich-541	60	16	residues	residue	NOUN
biomedich-541	60	17	,	,	PUNCT
biomedich-541	60	18	and	and	CCONJ
biomedich-541	60	19	these	these	DET
biomedich-541	60	20	residues	residue	NOUN
biomedich-541	60	21	also	also	ADV
biomedich-541	60	22	interact	interact	VERB
biomedich-541	60	23	with	with	ADP
biomedich-541	60	24	the	the	DET
biomedich-541	60	25	inhibitors	inhibitor	NOUN
biomedich-541	60	26	(	(	PUNCT
biomedich-541	60	27	table	table	NOUN
biomedich-541	60	28	1	1	NUM
biomedich-541	60	29	)	)	PUNCT
biomedich-541	60	30	.	.	PUNCT
biomedich-541	61	1	figure	figure	NOUN
biomedich-541	61	2	3	3	NUM
biomedich-541	61	3	illustrates	illustrate	VERB
biomedich-541	61	4	the	the	DET
biomedich-541	61	5	interactions	interaction	NOUN
biomedich-541	61	6	between	between	ADP
biomedich-541	61	7	the	the	DET
biomedich-541	61	8	inhibitors	inhibitor	NOUN
biomedich-541	61	9	and	and	CCONJ
biomedich-541	61	10	the	the	DET
biomedich-541	61	11	amino	amino	NOUN
biomedich-541	61	12	acid	acid	NOUN
biomedich-541	61	13	residues	residue	NOUN
biomedich-541	61	14	present	present	ADJ
biomedich-541	61	15	at	at	ADP
biomedich-541	61	16	the	the	DET
biomedich-541	61	17	enzyme	enzyme	NOUN
biomedich-541	61	18	's	's	PART
biomedich-541	61	19	active	active	ADJ
biomedich-541	61	20	site	site	NOUN
biomedich-541	61	21	.	.	PUNCT
biomedich-541	62	1	in	in	ADP
biomedich-541	62	2	the	the	DET
biomedich-541	62	3	ace1	ace1	PROPN
biomedich-541	62	4	inhibitor	inhibitor	NOUN
biomedich-541	62	5	,	,	PUNCT
biomedich-541	62	6	captopril	captopril	NOUN
biomedich-541	62	7	,	,	PUNCT
biomedich-541	62	8	enalaprilat	enalaprilat	ADJ
biomedich-541	62	9	,	,	PUNCT
biomedich-541	62	10	and	and	CCONJ
biomedich-541	62	11	lisinopril	lisinopril	NOUN
biomedich-541	62	12	had	have	VERB
biomedich-541	62	13	similar	similar	ADJ
biomedich-541	62	14	interactions	interaction	NOUN
biomedich-541	62	15	,	,	PUNCT
biomedich-541	62	16	where	where	SCONJ
biomedich-541	62	17	the	the	DET
biomedich-541	62	18	bound	bind	VERB
biomedich-541	62	19	amino	amino	NOUN
biomedich-541	62	20	acid	acid	NOUN
biomedich-541	62	21	residues	residue	NOUN
biomedich-541	62	22	include	include	VERB
biomedich-541	62	23	glu162	glu162	PROPN
biomedich-541	62	24	,	,	PUNCT
biomedich-541	62	25	gln281	gln281	PROPN
biomedich-541	62	26	,	,	PUNCT
biomedich-541	62	27	his353	his353	PROPN
biomedich-541	62	28	,	,	PUNCT
biomedich-541	62	29	his383	his383	PROPN
biomedich-541	62	30	,	,	PUNCT
biomedich-541	62	31	glu384	glu384	PROPN
biomedich-541	62	32	,	,	PUNCT
biomedich-541	62	33	his387	his387	PROPN
biomedich-541	62	34	,	,	PUNCT
biomedich-541	62	35	lys511	lys511	PROPN
biomedich-541	62	36	,	,	PUNCT
biomedich-541	62	37	his513	his513	PROPN
biomedich-541	62	38	,	,	PUNCT
biomedich-541	62	39	tyr520	tyr520	PROPN
biomedich-541	62	40	,	,	PUNCT
biomedich-541	62	41	and	and	CCONJ
biomedich-541	62	42	tyr	tyr	PROPN
biomedich-541	62	43	523	523	NUM
biomedich-541	62	44	.	.	PUNCT
biomedich-541	63	1	additionally	additionally	ADV
biomedich-541	63	2	,	,	PUNCT
biomedich-541	63	3	metal	metal	NOUN
biomedich-541	63	4	coordination	coordination	NOUN
biomedich-541	63	5	bonds	bond	NOUN
biomedich-541	63	6	are	be	AUX
biomedich-541	63	7	formed	form	VERB
biomedich-541	63	8	between	between	ADP
biomedich-541	63	9	the	the	DET
biomedich-541	63	10	carboxylate	carboxylate	NOUN
biomedich-541	63	11	groups	group	NOUN
biomedich-541	63	12	of	of	ADP
biomedich-541	63	13	the	the	DET
biomedich-541	63	14	inhibitors	inhibitor	NOUN
biomedich-541	63	15	and	and	CCONJ
biomedich-541	63	16	zn	zn	PROPN
biomedich-541	63	17	,	,	PUNCT
biomedich-541	63	18	an	an	DET
biomedich-541	63	19	ace	ace	NOUN
biomedich-541	63	20	cofactor	cofactor	NOUN
biomedich-541	63	21	.	.	PUNCT
biomedich-541	64	1	some	some	DET
biomedich-541	64	2	interaction	interaction	NOUN
biomedich-541	64	3	patterns	pattern	NOUN
biomedich-541	64	4	observed	observe	VERB
biomedich-541	64	5	in	in	ADP
biomedich-541	64	6	ace1	ace1	PROPN
biomedich-541	64	7	are	be	AUX
biomedich-541	64	8	also	also	ADV
biomedich-541	64	9	present	present	ADJ
biomedich-541	64	10	in	in	ADP
biomedich-541	64	11	ace2	ace2	PROPN
biomedich-541	64	12	,	,	PUNCT
biomedich-541	64	13	such	such	ADJ
biomedich-541	64	14	as	as	ADP
biomedich-541	64	15	the	the	DET
biomedich-541	64	16	carboxylate	carboxylate	NOUN
biomedich-541	64	17	group	group	NOUN
biomedich-541	64	18	of	of	ADP
biomedich-541	64	19	mln-4760	mln-4760	NOUN
biomedich-541	64	20	binding	bind	VERB
biomedich-541	64	21	to	to	ADP
biomedich-541	64	22	zn	zn	PROPN
biomedich-541	64	23	.	.	PUNCT
biomedich-541	65	1	furthermore	furthermore	ADV
biomedich-541	65	2	,	,	PUNCT
biomedich-541	65	3	mln-4760	mln-4760	NOUN
biomedich-541	65	4	also	also	ADV
biomedich-541	65	5	bound	bind	VERB
biomedich-541	65	6	to	to	ADP
biomedich-541	65	7	several	several	ADJ
biomedich-541	65	8	amino	amino	NOUN
biomedich-541	65	9	acid	acid	NOUN
biomedich-541	65	10	residues	residue	NOUN
biomedich-541	65	11	such	such	ADJ
biomedich-541	65	12	as	as	ADP
biomedich-541	65	13	arg273	arg273	PROPN
biomedich-541	65	14	,	,	PUNCT
biomedich-541	65	15	cys344	cys344	PROPN
biomedich-541	65	16	,	,	PUNCT
biomedich-541	65	17	his345	his345	PROPN
biomedich-541	65	18	,	,	PUNCT
biomedich-541	65	19	pro346	pro346	NOUN
biomedich-541	65	20	,	,	PUNCT
biomedich-541	65	21	asp368	asp368	PROPN
biomedich-541	65	22	,	,	PUNCT
biomedich-541	65	23	thr371	thr371	PROPN
biomedich-541	65	24	,	,	PUNCT
biomedich-541	65	25	glu375	glu375	PROPN
biomedich-541	65	26	,	,	PUNCT
biomedich-541	65	27	his378	his378	PROPN
biomedich-541	65	28	,	,	PUNCT
biomedich-541	65	29	and	and	CCONJ
biomedich-541	65	30	his505	his505	PROPN
biomedich-541	65	31	.	.	PROPN
biomedich-541	66	1	figure	figure	NOUN
biomedich-541	66	2	4	4	NUM
biomedich-541	66	3	depicted	depict	VERB
biomedich-541	66	4	the	the	DET
biomedich-541	66	5	3d	3d	NUM
biomedich-541	66	6	visualization	visualization	NOUN
biomedich-541	66	7	for	for	ADP
biomedich-541	66	8	both	both	DET
biomedich-541	66	9	enzymes	enzyme	NOUN
biomedich-541	66	10	,	,	PUNCT
biomedich-541	66	11	which	which	PRON
biomedich-541	66	12	was	be	AUX
biomedich-541	66	13	used	use	VERB
biomedich-541	66	14	to	to	PART
biomedich-541	66	15	identify	identify	VERB
biomedich-541	66	16	the	the	DET
biomedich-541	66	17	types	type	NOUN
biomedich-541	66	18	of	of	ADP
biomedich-541	66	19	interactions	interaction	NOUN
biomedich-541	66	20	between	between	ADP
biomedich-541	66	21	the	the	DET
biomedich-541	66	22	inhibitors	inhibitor	NOUN
biomedich-541	66	23	and	and	CCONJ
biomedich-541	66	24	the	the	DET
biomedich-541	66	25	amino	amino	NOUN
biomedich-541	66	26	acid	acid	NOUN
biomedich-541	66	27	residues	residue	NOUN
biomedich-541	66	28	.	.	PUNCT
biomedich-541	67	1	hydrogen	hydrogen	NOUN
biomedich-541	67	2	bonds	bond	NOUN
biomedich-541	67	3	and	and	CCONJ
biomedich-541	67	4	metal	metal	NOUN
biomedich-541	67	5	coordination	coordination	NOUN
biomedich-541	67	6	with	with	ADP
biomedich-541	67	7	zn	zn	PROPN
biomedich-541	67	8	were	be	AUX
biomedich-541	67	9	formed	form	VERB
biomedich-541	67	10	in	in	ADP
biomedich-541	67	11	both	both	PRON
biomedich-541	67	12	ace1	ace1	PROPN
biomedich-541	67	13	and	and	CCONJ
biomedich-541	67	14	ace2	ace2	PROPN
biomedich-541	67	15	.	.	PUNCT
biomedich-541	68	1	additionally	additionally	ADV
biomedich-541	68	2	,	,	PUNCT
biomedich-541	68	3	an	an	DET
biomedich-541	68	4	analysis	analysis	NOUN
biomedich-541	68	5	of	of	ADP
biomedich-541	68	6	the	the	DET
biomedich-541	68	7	active	active	ADJ
biomedich-541	68	8	site	site	NOUN
biomedich-541	68	9	surface	surface	NOUN
biomedich-541	68	10	was	be	AUX
biomedich-541	68	11	conducted	conduct	VERB
biomedich-541	68	12	to	to	PART
biomedich-541	68	13	determine	determine	VERB
biomedich-541	68	14	the	the	DET
biomedich-541	68	15	shape	shape	NOUN
biomedich-541	68	16	of	of	ADP
biomedich-541	68	17	the	the	DET
biomedich-541	68	18	active	active	ADJ
biomedich-541	68	19	site	site	NOUN
biomedich-541	68	20	and	and	CCONJ
biomedich-541	68	21	the	the	DET
biomedich-541	68	22	hydrophobicity	hydrophobicity	NOUN
biomedich-541	68	23	of	of	ADP
biomedich-541	68	24	the	the	DET
biomedich-541	68	25	enzyme	enzyme	NOUN
biomedich-541	68	26	's	's	PART
biomedich-541	68	27	active	active	ADJ
biomedich-541	68	28	site	site	NOUN
biomedich-541	68	29	.	.	PUNCT
biomedich-541	69	1	the	the	DET
biomedich-541	69	2	ace2	ace2	PROPN
biomedich-541	69	3	active	active	ADJ
biomedich-541	69	4	site	site	NOUN
biomedich-541	69	5	is	be	AUX
biomedich-541	69	6	narrower	narrow	ADJ
biomedich-541	69	7	than	than	ADP
biomedich-541	69	8	ace1	ace1	PROPN
biomedich-541	69	9	,	,	PUNCT
biomedich-541	69	10	especially	especially	ADV
biomedich-541	69	11	in	in	ADP
biomedich-541	69	12	the	the	DET
biomedich-541	69	13	central	central	ADJ
biomedich-541	69	14	area	area	NOUN
biomedich-541	69	15	and	and	CCONJ
biomedich-541	69	16	it	it	PRON
biomedich-541	69	17	is	be	AUX
biomedich-541	69	18	dominated	dominate	VERB
biomedich-541	69	19	by	by	ADP
biomedich-541	69	20	hydrophobicity	hydrophobicity	NOUN
biomedich-541	69	21	.	.	PUNCT
biomedich-541	70	1	figure	figure	NOUN
biomedich-541	70	2	4	4	NUM
biomedich-541	70	3	.	.	X
biomedich-541	71	1	3d	3d	NUM
biomedich-541	71	2	visualization	visualization	NOUN
biomedich-541	71	3	of	of	ADP
biomedich-541	71	4	lisinopril	lisinopril	NOUN
biomedich-541	71	5	with	with	ADP
biomedich-541	71	6	ace	ace	PROPN
biomedich-541	71	7	1	1	NUM
biomedich-541	71	8	(	(	PUNCT
biomedich-541	71	9	a	a	NOUN
biomedich-541	71	10	)	)	PUNCT
biomedich-541	71	11	and	and	CCONJ
biomedich-541	71	12	mln-4760	mln-4760	NOUN
biomedich-541	71	13	with	with	ADP
biomedich-541	71	14	ace2	ace2	PROPN
biomedich-541	71	15	.	.	PUNCT
biomedich-541	72	1	the	the	DET
biomedich-541	72	2	3d	3d	PROPN
biomedich-541	72	3	interaction	interaction	NOUN
biomedich-541	72	4	of	of	ADP
biomedich-541	72	5	the	the	DET
biomedich-541	72	6	inhibitors	inhibitor	NOUN
biomedich-541	72	7	at	at	ADP
biomedich-541	72	8	the	the	DET
biomedich-541	72	9	active	active	ADJ
biomedich-541	72	10	site	site	NOUN
biomedich-541	72	11	with	with	ADP
biomedich-541	72	12	amino	amino	NOUN
biomedich-541	72	13	acid	acid	NOUN
biomedich-541	72	14	residues	residue	NOUN
biomedich-541	72	15	(	(	PUNCT
biomedich-541	72	16	above	above	ADV
biomedich-541	72	17	)	)	PUNCT
biomedich-541	72	18	;	;	PUNCT
biomedich-541	72	19	the	the	DET
biomedich-541	72	20	surfaces	surface	NOUN
biomedich-541	72	21	of	of	ADP
biomedich-541	72	22	active	active	ADJ
biomedich-541	72	23	site	site	NOUN
biomedich-541	72	24	in	in	ADP
biomedich-541	72	25	both	both	DET
biomedich-541	72	26	enzymes	enzyme	NOUN
biomedich-541	72	27	with	with	ADP
biomedich-541	72	28	purple	purple	NOUN
biomedich-541	72	29	for	for	ADP
biomedich-541	72	30	hidrophilicity	hidrophilicity	ADV
biomedich-541	72	31	/	/	SYM
biomedich-541	72	32	polar	polar	ADJ
biomedich-541	72	33	and	and	CCONJ
biomedich-541	72	34	green	green	ADJ
biomedich-541	72	35	for	for	ADP
biomedich-541	72	36	hydrophibicity	hydrophibicity	NOUN
biomedich-541	72	37	(	(	PUNCT
biomedich-541	72	38	below	below	ADV
biomedich-541	72	39	)	)	PUNCT
biomedich-541	72	40	.	.	PUNCT
biomedich-541	73	1	discussion	discussion	NOUN
biomedich-541	73	2	in	in	ADP
biomedich-541	73	3	this	this	PRON
biomedich-541	73	4	in	in	ADP
biomedich-541	73	5	silico	silico	NOUN
biomedich-541	73	6	studies	study	NOUN
biomedich-541	73	7	,	,	PUNCT
biomedich-541	73	8	pharmacophore	pharmacophore	ADJ
biomedich-541	73	9	mapping	mapping	NOUN
biomedich-541	73	10	was	be	AUX
biomedich-541	73	11	conducted	conduct	VERB
biomedich-541	73	12	to	to	PART
biomedich-541	73	13	analyze	analyze	VERB
biomedich-541	73	14	the	the	DET
biomedich-541	73	15	differences	difference	NOUN
biomedich-541	73	16	in	in	ADP
biomedich-541	73	17	the	the	DET
biomedich-541	73	18	active	active	ADJ
biomedich-541	73	19	sites	site	NOUN
biomedich-541	73	20	of	of	ADP
biomedich-541	73	21	ace1	ace1	PROPN
biomedich-541	73	22	and	and	CCONJ
biomedich-541	73	23	ace2	ace2	PROPN
biomedich-541	73	24	,	,	PUNCT
biomedich-541	73	25	which	which	PRON
biomedich-541	73	26	are	be	AUX
biomedich-541	73	27	homologous	homologous	ADJ
biomedich-541	73	28	proteins	protein	NOUN
biomedich-541	73	29	based	base	VERB
biomedich-541	73	30	on	on	ADP
biomedich-541	73	31	their	their	PRON
biomedich-541	73	32	backbone	backbone	NOUN
biomedich-541	73	33	similarity	similarity	NOUN
biomedich-541	73	34	or	or	CCONJ
biomedich-541	73	35	tertiary	tertiary	ADJ
biomedich-541	73	36	structures	structure	NOUN
biomedich-541	73	37	.	.	PUNCT
biomedich-541	74	1	three	three	NUM
biomedich-541	74	2	340	340	NUM
biomedich-541	74	3	biology	biology	NOUN
biomedich-541	74	4	,	,	PUNCT
biomedich-541	74	5	medicine	medicine	NOUN
biomedich-541	74	6	,	,	PUNCT
biomedich-541	74	7	&	&	CCONJ
biomedich-541	74	8	natural	natural	ADJ
biomedich-541	74	9	product	product	NOUN
biomedich-541	74	10	chemistry	chemistry	NOUN
biomedich-541	74	11	13	13	NUM
biomedich-541	74	12	(	(	PUNCT
biomedich-541	74	13	2	2	NUM
biomedich-541	74	14	)	)	PUNCT
biomedich-541	74	15	,	,	PUNCT
biomedich-541	74	16	2024	2024	NUM
biomedich-541	74	17	:	:	PUNCT
biomedich-541	74	18	337	337	NUM
biomedich-541	74	19	-	-	SYM
biomedich-541	74	20	341	341	NUM
biomedich-541	74	21	3d	3d	NUM
biomedich-541	74	22	structures	structure	NOUN
biomedich-541	74	23	of	of	ADP
biomedich-541	74	24	ace1	ace1	PROPN
biomedich-541	74	25	were	be	AUX
biomedich-541	74	26	used	use	VERB
biomedich-541	74	27	with	with	ADP
biomedich-541	74	28	their	their	PRON
biomedich-541	74	29	corresponding	correspond	VERB
biomedich-541	74	30	inhibitors	inhibitor	NOUN
biomedich-541	74	31	:	:	PUNCT
biomedich-541	74	32	captopril	captopril	NOUN
biomedich-541	74	33	,	,	PUNCT
biomedich-541	74	34	enalaprilat	enalaprilat	ADJ
biomedich-541	74	35	,	,	PUNCT
biomedich-541	74	36	and	and	CCONJ
biomedich-541	74	37	lisinopril	lisinopril	NOUN
biomedich-541	74	38	,	,	PUNCT
biomedich-541	74	39	while	while	SCONJ
biomedich-541	74	40	ace2	ace2	PROPN
biomedich-541	74	41	was	be	AUX
biomedich-541	74	42	bound	bind	VERB
biomedich-541	74	43	to	to	ADP
biomedich-541	74	44	an	an	DET
biomedich-541	74	45	inhibitor	inhibitor	NOUN
biomedich-541	74	46	,	,	PUNCT
biomedich-541	74	47	mln4760	mln4760	NOUN
biomedich-541	74	48	.	.	PUNCT
biomedich-541	75	1	the	the	DET
biomedich-541	75	2	active	active	ADJ
biomedich-541	75	3	site	site	NOUN
biomedich-541	75	4	of	of	ADP
biomedich-541	75	5	both	both	DET
biomedich-541	75	6	enzymes	enzyme	NOUN
biomedich-541	75	7	is	be	AUX
biomedich-541	75	8	located	locate	VERB
biomedich-541	75	9	at	at	ADP
biomedich-541	75	10	the	the	DET
biomedich-541	75	11	centre	centre	NOUN
biomedich-541	75	12	of	of	ADP
biomedich-541	75	13	their	their	PRON
biomedich-541	75	14	respective	respective	ADJ
biomedich-541	75	15	structures	structure	NOUN
biomedich-541	75	16	.	.	PUNCT
biomedich-541	76	1	it	it	PRON
biomedich-541	76	2	can	can	AUX
biomedich-541	76	3	be	be	AUX
biomedich-541	76	4	observed	observe	VERB
biomedich-541	76	5	that	that	SCONJ
biomedich-541	76	6	both	both	DET
biomedich-541	76	7	share	share	NOUN
biomedich-541	76	8	similarities	similarity	NOUN
biomedich-541	76	9	in	in	ADP
biomedich-541	76	10	some	some	DET
biomedich-541	76	11	amino	amino	NOUN
biomedich-541	76	12	acid	acid	NOUN
biomedich-541	76	13	residues	residue	NOUN
biomedich-541	76	14	thus	thus	ADV
biomedich-541	76	15	ace1	ace1	NOUN
biomedich-541	76	16	inhibitors	inhibitor	NOUN
biomedich-541	76	17	and	and	CCONJ
biomedich-541	76	18	ace2	ace2	NOUN
biomedich-541	76	19	inhibitors	inhibitor	NOUN
biomedich-541	76	20	have	have	VERB
biomedich-541	76	21	similar	similar	ADJ
biomedich-541	76	22	type	type	NOUN
biomedich-541	76	23	of	of	ADP
biomedich-541	76	24	interactions	interaction	NOUN
biomedich-541	76	25	.	.	PUNCT
biomedich-541	77	1	however	however	ADV
biomedich-541	77	2	,	,	PUNCT
biomedich-541	77	3	it	it	PRON
biomedich-541	77	4	was	be	AUX
biomedich-541	77	5	found	find	VERB
biomedich-541	77	6	that	that	SCONJ
biomedich-541	77	7	there	there	PRON
biomedich-541	77	8	is	be	VERB
biomedich-541	77	9	a	a	DET
biomedich-541	77	10	subtle	subtle	ADJ
biomedich-541	77	11	difference	difference	NOUN
biomedich-541	77	12	in	in	ADP
biomedich-541	77	13	their	their	PRON
biomedich-541	77	14	interaction	interaction	NOUN
biomedich-541	77	15	due	due	ADP
biomedich-541	77	16	to	to	ADP
biomedich-541	77	17	the	the	DET
biomedich-541	77	18	functional	functional	ADJ
biomedich-541	77	19	groups	group	NOUN
biomedich-541	77	20	of	of	ADP
biomedich-541	77	21	both	both	DET
biomedich-541	77	22	inhibitors	inhibitor	NOUN
biomedich-541	77	23	.	.	PUNCT
biomedich-541	78	1	in	in	ADP
biomedich-541	78	2	addition	addition	NOUN
biomedich-541	78	3	,	,	PUNCT
biomedich-541	78	4	the	the	DET
biomedich-541	78	5	size	size	NOUN
biomedich-541	78	6	of	of	ADP
biomedich-541	78	7	ace2	ace2	PROPN
biomedich-541	78	8	active	active	ADJ
biomedich-541	78	9	site	site	NOUN
biomedich-541	78	10	is	be	AUX
biomedich-541	78	11	slightly	slightly	ADV
biomedich-541	78	12	narrower	narrow	ADJ
biomedich-541	78	13	than	than	ADP
biomedich-541	78	14	ace1	ace1	PROPN
biomedich-541	78	15	active	active	ADJ
biomedich-541	78	16	site	site	NOUN
biomedich-541	78	17	.	.	PUNCT
biomedich-541	79	1	it	it	PRON
biomedich-541	79	2	has	have	AUX
biomedich-541	79	3	been	be	AUX
biomedich-541	79	4	known	know	VERB
biomedich-541	79	5	that	that	SCONJ
biomedich-541	79	6	ace1	ace1	PROPN
biomedich-541	79	7	inhibitors	inhibitor	NOUN
biomedich-541	79	8	are	be	AUX
biomedich-541	79	9	mostly	mostly	ADV
biomedich-541	79	10	bulky	bulky	ADJ
biomedich-541	79	11	compounds	compound	NOUN
biomedich-541	79	12	and	and	CCONJ
biomedich-541	79	13	therefore	therefore	ADV
biomedich-541	79	14	they	they	PRON
biomedich-541	79	15	could	could	AUX
biomedich-541	79	16	not	not	PART
biomedich-541	79	17	occupy	occupy	VERB
biomedich-541	79	18	the	the	DET
biomedich-541	79	19	ace2	ace2	PROPN
biomedich-541	79	20	active	active	ADJ
biomedich-541	79	21	site	site	NOUN
biomedich-541	79	22	.	.	PUNCT
biomedich-541	80	1	furthermore	furthermore	ADV
biomedich-541	80	2	,	,	PUNCT
biomedich-541	80	3	the	the	DET
biomedich-541	80	4	ace2	ace2	PROPN
biomedich-541	80	5	active	active	ADJ
biomedich-541	80	6	site	site	NOUN
biomedich-541	80	7	is	be	AUX
biomedich-541	80	8	also	also	ADV
biomedich-541	80	9	dominated	dominate	VERB
biomedich-541	80	10	by	by	ADP
biomedich-541	80	11	hydrophobicity	hydrophobicity	NOUN
biomedich-541	80	12	,	,	PUNCT
biomedich-541	80	13	making	make	VERB
biomedich-541	80	14	polar	polar	ADJ
biomedich-541	80	15	groups	group	NOUN
biomedich-541	80	16	,	,	PUNCT
biomedich-541	80	17	especially	especially	ADV
biomedich-541	80	18	in	in	ADP
biomedich-541	80	19	the	the	DET
biomedich-541	80	20	central	central	ADJ
biomedich-541	80	21	area	area	NOUN
biomedich-541	80	22	of	of	ADP
biomedich-541	80	23	the	the	DET
biomedich-541	80	24	compound	compound	NOUN
biomedich-541	80	25	,	,	PUNCT
biomedich-541	80	26	more	more	ADV
biomedich-541	80	27	likely	likely	ADJ
biomedich-541	80	28	to	to	PART
biomedich-541	80	29	bind	bind	VERB
biomedich-541	80	30	to	to	ADP
biomedich-541	80	31	ace2	ace2	NOUN
biomedich-541	80	32	.	.	PUNCT
biomedich-541	81	1	consequently	consequently	ADV
biomedich-541	81	2	,	,	PUNCT
biomedich-541	81	3	these	these	DET
biomedich-541	81	4	differences	difference	NOUN
biomedich-541	81	5	cause	cause	VERB
biomedich-541	81	6	ace1	ace1	NOUN
biomedich-541	81	7	inhibitors	inhibitor	NOUN
biomedich-541	81	8	to	to	PART
biomedich-541	81	9	be	be	AUX
biomedich-541	81	10	unable	unable	ADJ
biomedich-541	81	11	to	to	PART
biomedich-541	81	12	occupy	occupy	VERB
biomedich-541	81	13	the	the	DET
biomedich-541	81	14	ace2	ace2	PROPN
biomedich-541	81	15	active	active	ADJ
biomedich-541	81	16	site	site	NOUN
biomedich-541	81	17	.	.	PUNCT
biomedich-541	82	1	in	in	ADP
biomedich-541	82	2	conclusion	conclusion	NOUN
biomedich-541	82	3	,	,	PUNCT
biomedich-541	82	4	these	these	DET
biomedich-541	82	5	preliminary	preliminary	ADJ
biomedich-541	82	6	findings	finding	NOUN
biomedich-541	82	7	could	could	AUX
biomedich-541	82	8	provide	provide	VERB
biomedich-541	82	9	useful	useful	ADJ
biomedich-541	82	10	information	information	NOUN
biomedich-541	82	11	in	in	ADP
biomedich-541	82	12	designing	design	VERB
biomedich-541	82	13	compounds	compound	NOUN
biomedich-541	82	14	that	that	PRON
biomedich-541	82	15	are	be	AUX
biomedich-541	82	16	selective	selective	ADJ
biomedich-541	82	17	towards	towards	ADP
biomedich-541	82	18	both	both	DET
biomedich-541	82	19	ace1	ace1	PROPN
biomedich-541	82	20	and	and	CCONJ
biomedich-541	82	21	ace2	ace2	PROPN
biomedich-541	82	22	.	.	PUNCT
biomedich-541	83	1	conclusions	conclusion	NOUN
biomedich-541	83	2	ace1	ace1	PROPN
biomedich-541	83	3	and	and	CCONJ
biomedich-541	83	4	ace2	ace2	PROPN
biomedich-541	83	5	are	be	AUX
biomedich-541	83	6	homologous	homologous	ADJ
biomedich-541	83	7	proteins	protein	NOUN
biomedich-541	83	8	based	base	VERB
biomedich-541	83	9	on	on	ADP
biomedich-541	83	10	their	their	PRON
biomedich-541	83	11	tertiary	tertiary	ADJ
biomedich-541	83	12	structure	structure	NOUN
biomedich-541	83	13	(	(	PUNCT
biomedich-541	83	14	backbone	backbone	NOUN
biomedich-541	83	15	)	)	PUNCT
biomedich-541	83	16	and	and	CCONJ
biomedich-541	83	17	their	their	PRON
biomedich-541	83	18	sequence	sequence	NOUN
biomedich-541	83	19	identity	identity	NOUN
biomedich-541	83	20	.	.	PUNCT
biomedich-541	84	1	ace1	ace1	PROPN
biomedich-541	84	2	inhibitors	inhibitor	NOUN
biomedich-541	84	3	,	,	PUNCT
biomedich-541	84	4	which	which	PRON
biomedich-541	84	5	are	be	AUX
biomedich-541	84	6	bulky	bulky	ADJ
biomedich-541	84	7	compounds	compound	NOUN
biomedich-541	84	8	,	,	PUNCT
biomedich-541	84	9	could	could	AUX
biomedich-541	84	10	not	not	PART
biomedich-541	84	11	occupy	occupy	VERB
biomedich-541	84	12	the	the	DET
biomedich-541	84	13	active	active	ADJ
biomedich-541	84	14	site	site	NOUN
biomedich-541	84	15	of	of	ADP
biomedich-541	84	16	ace2	ace2	PROPN
biomedich-541	84	17	due	due	ADP
biomedich-541	84	18	to	to	ADP
biomedich-541	84	19	its	its	PRON
biomedich-541	84	20	narrower	narrow	ADJ
biomedich-541	84	21	shape	shape	NOUN
biomedich-541	84	22	.	.	PUNCT
biomedich-541	85	1	in	in	ADP
biomedich-541	85	2	addition	addition	NOUN
biomedich-541	85	3	,	,	PUNCT
biomedich-541	85	4	the	the	DET
biomedich-541	85	5	active	active	ADJ
biomedich-541	85	6	site	site	NOUN
biomedich-541	85	7	of	of	ADP
biomedich-541	85	8	ace2	ace2	PROPN
biomedich-541	85	9	tends	tend	VERB
biomedich-541	85	10	to	to	PART
biomedich-541	85	11	be	be	AUX
biomedich-541	85	12	more	more	ADV
biomedich-541	85	13	polar	polar	ADJ
biomedich-541	85	14	or	or	CCONJ
biomedich-541	85	15	dominated	dominate	VERB
biomedich-541	85	16	by	by	ADP
biomedich-541	85	17	hydrophobicity	hydrophobicity	NOUN
biomedich-541	85	18	.	.	PUNCT
biomedich-541	86	1	acknowledgements	acknowledgement	NOUN
biomedich-541	86	2	:	:	PUNCT
biomedich-541	86	3	the	the	DET
biomedich-541	86	4	authors	author	NOUN
biomedich-541	86	5	express	express	VERB
biomedich-541	86	6	gratitude	gratitude	NOUN
biomedich-541	86	7	to	to	ADP
biomedich-541	86	8	the	the	DET
biomedich-541	86	9	faculty	faculty	NOUN
biomedich-541	86	10	of	of	ADP
biomedich-541	86	11	pharmacy	pharmacy	NOUN
biomedich-541	86	12	,	,	PUNCT
biomedich-541	86	13	ugm	ugm	PROPN
biomedich-541	86	14	for	for	ADP
biomedich-541	86	15	providing	provide	VERB
biomedich-541	86	16	the	the	DET
biomedich-541	86	17	licensedmoe	licensedmoe	PROPN
biomedich-541	86	18	software	software	NOUN
biomedich-541	86	19	.	.	PUNCT
biomedich-541	87	1	authors	author	NOUN
biomedich-541	87	2	’	'	PUNCT
biomedich-541	87	3	contributions	contribution	NOUN
biomedich-541	87	4	:	:	PUNCT
biomedich-541	87	5	navista	navista	PROPN
biomedich-541	87	6	sri	sri	PROPN
biomedich-541	87	7	octa	octa	PROPN
biomedich-541	87	8	ujiantari	ujiantari	PROPN
biomedich-541	87	9	designed	design	VERB
biomedich-541	87	10	the	the	DET
biomedich-541	87	11	study	study	NOUN
biomedich-541	87	12	,	,	PUNCT
biomedich-541	87	13	performed	perform	VERB
biomedich-541	87	14	the	the	DET
biomedich-541	87	15	pharmacophore	pharmacophore	NOUN
biomedich-541	87	16	modelling	modelling	NOUN
biomedich-541	87	17	,	,	PUNCT
biomedich-541	87	18	analyzed	analyze	VERB
biomedich-541	87	19	the	the	DET
biomedich-541	87	20	data	datum	NOUN
biomedich-541	87	21	,	,	PUNCT
biomedich-541	87	22	and	and	CCONJ
biomedich-541	87	23	wrote	write	VERB
biomedich-541	87	24	the	the	DET
biomedich-541	87	25	manuscript	manuscript	NOUN
biomedich-541	87	26	.	.	PUNCT
biomedich-541	88	1	cintya	cintya	PROPN
biomedich-541	88	2	nurul	nurul	PROPN
biomedich-541	88	3	apsari	apsari	NOUN
biomedich-541	88	4	carried	carry	VERB
biomedich-541	88	5	out	out	ADP
biomedich-541	88	6	the	the	DET
biomedich-541	88	7	data	data	NOUN
biomedich-541	88	8	collection	collection	NOUN
biomedich-541	88	9	and	and	CCONJ
biomedich-541	88	10	protein	protein	NOUN
biomedich-541	88	11	alignment	alignment	NOUN
biomedich-541	88	12	.	.	PUNCT
biomedich-541	89	1	all	all	DET
biomedich-541	89	2	authors	author	NOUN
biomedich-541	89	3	read	read	VERB
biomedich-541	89	4	and	and	CCONJ
biomedich-541	89	5	approved	approve	VERB
biomedich-541	89	6	the	the	DET
biomedich-541	89	7	final	final	ADJ
biomedich-541	89	8	version	version	NOUN
biomedich-541	89	9	of	of	ADP
biomedich-541	89	10	the	the	DET
biomedich-541	89	11	manuscript	manuscript	NOUN
biomedich-541	89	12	competing	compete	VERB
biomedich-541	89	13	interests	interest	NOUN
biomedich-541	89	14	:	:	PUNCT
biomedich-541	89	15	authors	author	NOUN
biomedich-541	89	16	declare	declare	VERB
biomedich-541	89	17	that	that	SCONJ
biomedich-541	89	18	there	there	PRON
biomedich-541	89	19	are	be	VERB
biomedich-541	89	20	no	no	DET
biomedich-541	89	21	competing	compete	VERB
biomedich-541	89	22	interests	interest	NOUN
biomedich-541	89	23	.	.	PUNCT
biomedich-541	90	1	references	reference	NOUN
biomedich-541	90	2	ahmad	ahmad	PROPN
biomedich-541	90	3	,	,	PUNCT
biomedich-541	90	4	h.	h.	PROPN
biomedich-541	90	5	,	,	PUNCT
biomedich-541	90	6	khan	khan	PROPN
biomedich-541	90	7	,	,	PUNCT
biomedich-541	90	8	h.	h.	PROPN
biomedich-541	90	9	,	,	PUNCT
biomedich-541	90	10	haque	haque	PROPN
biomedich-541	90	11	,	,	PUNCT
biomedich-541	90	12	s.	s.	PROPN
biomedich-541	90	13	,	,	PUNCT
biomedich-541	90	14	ahmad	ahmad	PROPN
biomedich-541	90	15	,	,	PUNCT
biomedich-541	90	16	s.	s.	PROPN
biomedich-541	90	17	,	,	PUNCT
biomedich-541	90	18	srivastava	srivastava	PROPN
biomedich-541	90	19	,	,	PUNCT
biomedich-541	90	20	n.	n.	PROPN
biomedich-541	90	21	,	,	PUNCT
biomedich-541	90	22	&	&	CCONJ
biomedich-541	90	23	khan	khan	PROPN
biomedich-541	90	24	,	,	PUNCT
biomedich-541	90	25	a.	a.	NOUN
biomedich-541	90	26	(	(	PUNCT
biomedich-541	90	27	2023	2023	NUM
biomedich-541	90	28	)	)	PUNCT
biomedich-541	90	29	.	.	PUNCT
biomedich-541	91	1	angiotensin	angiotensin	NOUN
biomedich-541	91	2	-	-	PUNCT
biomedich-541	91	3	converting	convert	VERB
biomedich-541	91	4	enzyme	enzyme	NOUN
biomedich-541	91	5	and	and	CCONJ
biomedich-541	91	6	hypertension	hypertension	NOUN
biomedich-541	91	7	:	:	PUNCT
biomedich-541	91	8	a	a	DET
biomedich-541	91	9	systemic	systemic	ADJ
biomedich-541	91	10	analysis	analysis	NOUN
biomedich-541	91	11	of	of	ADP
biomedich-541	91	12	various	various	ADJ
biomedich-541	91	13	ace	ace	NOUN
biomedich-541	91	14	inhibitors	inhibitor	NOUN
biomedich-541	91	15	,	,	PUNCT
biomedich-541	91	16	their	their	PRON
biomedich-541	91	17	side	side	NOUN
biomedich-541	91	18	effects	effect	NOUN
biomedich-541	91	19	,	,	PUNCT
biomedich-541	91	20	and	and	CCONJ
biomedich-541	91	21	bioactive	bioactive	VERB
biomedich-541	91	22	peptides	peptide	NOUN
biomedich-541	91	23	as	as	ADP
biomedich-541	91	24	a	a	DET
biomedich-541	91	25	putative	putative	ADJ
biomedich-541	91	26	therapy	therapy	NOUN
biomedich-541	91	27	for	for	ADP
biomedich-541	91	28	hypertension	hypertension	NOUN
biomedich-541	91	29	.	.	PUNCT
biomedich-541	92	1	journal	journal	NOUN
biomedich-541	92	2	of	of	ADP
biomedich-541	92	3	the	the	DET
biomedich-541	92	4	reninangiotensin	reninangiotensin	NOUN
biomedich-541	92	5	-	-	PUNCT
biomedich-541	92	6	aldosterone	aldosterone	NOUN
biomedich-541	92	7	system	system	NOUN
biomedich-541	92	8	:	:	PUNCT
biomedich-541	92	9	jraas	jraas	ADJ
biomedich-541	92	10	,	,	PUNCT
biomedich-541	92	11	2023	2023	NUM
biomedich-541	92	12	,	,	PUNCT
biomedich-541	92	13	7890188	7890188	NUM
biomedich-541	92	14	.	.	PUNCT
biomedich-541	93	1	https://doi.org/10.1155/2023/7890188	https://doi.org/10.1155/2023/7890188	PROPN
biomedich-541	93	2	ahmad	ahmad	PROPN
biomedich-541	93	3	,	,	PUNCT
biomedich-541	93	4	i.	i.	PROPN
biomedich-541	93	5	,	,	PUNCT
biomedich-541	93	6	pawara	pawara	NOUN
biomedich-541	93	7	,	,	PUNCT
biomedich-541	93	8	r.	r.	PROPN
biomedich-541	93	9	,	,	PUNCT
biomedich-541	93	10	surana	surana	PROPN
biomedich-541	93	11	,	,	PUNCT
biomedich-541	93	12	s.	s.	PROPN
biomedich-541	93	13	,	,	PUNCT
biomedich-541	93	14	&	&	CCONJ
biomedich-541	93	15	patel	patel	PROPN
biomedich-541	93	16	,	,	PUNCT
biomedich-541	93	17	h.	h.	PROPN
biomedich-541	93	18	(	(	PUNCT
biomedich-541	93	19	2021	2021	NUM
biomedich-541	93	20	)	)	PUNCT
biomedich-541	93	21	.	.	PUNCT
biomedich-541	94	1	the	the	DET
biomedich-541	94	2	repurposed	repurpose	VERB
biomedich-541	94	3	ace2	ace2	NOUN
biomedich-541	94	4	inhibitors	inhibitor	NOUN
biomedich-541	94	5	:	:	PUNCT
biomedich-541	94	6	sars	sar	NOUN
biomedich-541	94	7	-	-	PUNCT
biomedich-541	94	8	cov-2	cov-2	PART
biomedich-541	94	9	entry	entry	NOUN
biomedich-541	94	10	blockers	blocker	NOUN
biomedich-541	94	11	of	of	ADP
biomedich-541	94	12	covid-19	covid-19	PROPN
biomedich-541	94	13	.	.	PUNCT
biomedich-541	95	1	topics	topic	NOUN
biomedich-541	95	2	in	in	ADP
biomedich-541	95	3	current	current	ADJ
biomedich-541	95	4	chemistry	chemistry	NOUN
biomedich-541	95	5	(	(	PUNCT
biomedich-541	95	6	cham	cham	PROPN
biomedich-541	95	7	)	)	PUNCT
biomedich-541	95	8	,	,	PUNCT
biomedich-541	95	9	379(6	379(6	NUM
biomedich-541	95	10	)	)	PUNCT
biomedich-541	95	11	,	,	PUNCT
biomedich-541	95	12	40	40	NUM
biomedich-541	95	13	.	.	PUNCT
biomedich-541	96	1	https://doi.org/10.1007/s41061-021-00353-7	https://doi.org/10.1007/s41061-021-00353-7	NUM
biomedich-541	96	2	álvarez	álvarez	PROPN
biomedich-541	96	3	-	-	PUNCT
biomedich-541	96	4	zaballos	zaballos	PROPN
biomedich-541	96	5	,	,	PUNCT
biomedich-541	96	6	s.	s.	PROPN
biomedich-541	96	7	,	,	PUNCT
biomedich-541	96	8	&	&	CCONJ
biomedich-541	96	9	martínez	martínez	PROPN
biomedich-541	96	10	-	-	PUNCT
biomedich-541	96	11	sellés	sellés	PROPN
biomedich-541	96	12	,	,	PUNCT
biomedich-541	96	13	m.	m.	NOUN
biomedich-541	96	14	(	(	PUNCT
biomedich-541	96	15	2023	2023	NUM
biomedich-541	96	16	)	)	PUNCT
biomedich-541	96	17	.	.	PUNCT
biomedich-541	97	1	angiotensinconverting	angiotensinconverte	VERB
biomedich-541	97	2	enzyme	enzyme	NOUN
biomedich-541	97	3	and	and	CCONJ
biomedich-541	97	4	heart	heart	NOUN
biomedich-541	97	5	failure	failure	NOUN
biomedich-541	97	6	.	.	PUNCT
biomedich-541	98	1	frontiers	frontier	NOUN
biomedich-541	98	2	in	in	ADP
biomedich-541	98	3	bioscience	bioscience	PROPN
biomedich-541	98	4	(	(	PUNCT
biomedich-541	98	5	landmark	landmark	PROPN
biomedich-541	98	6	edition	edition	PROPN
biomedich-541	98	7	)	)	PUNCT
biomedich-541	98	8	,	,	PUNCT
biomedich-541	98	9	28(7	28(7	NUM
biomedich-541	98	10	)	)	PUNCT
biomedich-541	98	11	,	,	PUNCT
biomedich-541	98	12	150	150	NUM
biomedich-541	98	13	.	.	PUNCT
biomedich-541	99	1	https://doi.org/10.31083/j.fbl2807150	https://doi.org/10.31083/j.fbl2807150	ADJ
biomedich-541	99	2	ames	ame	NOUN
biomedich-541	99	3	,	,	PUNCT
biomedich-541	99	4	m.	m.	PROPN
biomedich-541	99	5	k.	k.	PROPN
biomedich-541	99	6	,	,	PUNCT
biomedich-541	99	7	atkins	atkins	PROPN
biomedich-541	99	8	,	,	PUNCT
biomedich-541	99	9	c.	c.	PROPN
biomedich-541	99	10	e.	e.	PROPN
biomedich-541	99	11	,	,	PUNCT
biomedich-541	99	12	&	&	CCONJ
biomedich-541	99	13	pitt	pitt	PROPN
biomedich-541	99	14	,	,	PUNCT
biomedich-541	99	15	b.	b.	PROPN
biomedich-541	99	16	(	(	PUNCT
biomedich-541	99	17	2019	2019	NUM
biomedich-541	99	18	)	)	PUNCT
biomedich-541	99	19	.	.	PUNCT
biomedich-541	100	1	the	the	DET
biomedich-541	100	2	reninangiotensin	reninangiotensin	NOUN
biomedich-541	100	3	-	-	PUNCT
biomedich-541	100	4	aldosterone	aldosterone	NOUN
biomedich-541	100	5	system	system	NOUN
biomedich-541	100	6	and	and	CCONJ
biomedich-541	100	7	its	its	PRON
biomedich-541	100	8	suppression	suppression	NOUN
biomedich-541	100	9	.	.	PUNCT
biomedich-541	101	1	journal	journal	PROPN
biomedich-541	101	2	of	of	ADP
biomedich-541	101	3	veterinary	veterinary	ADJ
biomedich-541	101	4	internal	internal	ADJ
biomedich-541	101	5	medicine	medicine	NOUN
biomedich-541	101	6	,	,	PUNCT
biomedich-541	101	7	33(2	33(2	NUM
biomedich-541	101	8	)	)	PUNCT
biomedich-541	101	9	,	,	PUNCT
biomedich-541	101	10	363–382	363–382	NUM
biomedich-541	101	11	.	.	PUNCT
biomedich-541	101	12	https://doi.org/10.1111/jvim.15454	https://doi.org/10.1111/jvim.15454	NOUN
biomedich-541	101	13	boutet	boutet	NOUN
biomedich-541	101	14	,	,	PUNCT
biomedich-541	101	15	e.	e.	PROPN
biomedich-541	101	16	,	,	PUNCT
biomedich-541	101	17	lieberherr	lieberherr	PROPN
biomedich-541	101	18	,	,	PUNCT
biomedich-541	101	19	d.	d.	PROPN
biomedich-541	101	20	,	,	PUNCT
biomedich-541	101	21	tognolli	tognolli	PROPN
biomedich-541	101	22	,	,	PUNCT
biomedich-541	101	23	m.	m.	NOUN
biomedich-541	101	24	,	,	PUNCT
biomedich-541	101	25	schneider	schneider	NOUN
biomedich-541	101	26	,	,	PUNCT
biomedich-541	101	27	m.	m.	NOUN
biomedich-541	101	28	,	,	PUNCT
biomedich-541	101	29	bansal	bansal	NOUN
biomedich-541	101	30	,	,	PUNCT
biomedich-541	101	31	p.	p.	NOUN
biomedich-541	101	32	,	,	PUNCT
biomedich-541	101	33	bridge	bridge	PROPN
biomedich-541	101	34	,	,	PUNCT
biomedich-541	101	35	a.	a.	PROPN
biomedich-541	101	36	j.	j.	PROPN
biomedich-541	101	37	,	,	PUNCT
biomedich-541	101	38	poux	poux	NOUN
biomedich-541	101	39	,	,	PUNCT
biomedich-541	101	40	s.	s.	PROPN
biomedich-541	101	41	,	,	PUNCT
biomedich-541	101	42	bougueleret	bougueleret	PROPN
biomedich-541	101	43	,	,	PUNCT
biomedich-541	101	44	l.	l.	PROPN
biomedich-541	101	45	,	,	PUNCT
biomedich-541	101	46	&	&	CCONJ
biomedich-541	101	47	xenarios	xenarios	PROPN
biomedich-541	101	48	,	,	PUNCT
biomedich-541	101	49	i.	i.	NOUN
biomedich-541	101	50	(	(	PUNCT
biomedich-541	101	51	2016	2016	NUM
biomedich-541	101	52	)	)	PUNCT
biomedich-541	101	53	.	.	PUNCT
biomedich-541	102	1	uniprotkb	uniprotkb	ADJ
biomedich-541	102	2	/	/	SYM
biomedich-541	102	3	swiss	swiss	ADJ
biomedich-541	102	4	-	-	PUNCT
biomedich-541	102	5	prot	prot	NOUN
biomedich-541	102	6	,	,	PUNCT
biomedich-541	102	7	the	the	DET
biomedich-541	102	8	manually	manually	ADV
biomedich-541	102	9	annotated	annotate	VERB
biomedich-541	102	10	section	section	NOUN
biomedich-541	102	11	of	of	ADP
biomedich-541	102	12	the	the	DET
biomedich-541	102	13	uniprot	uniprot	ADJ
biomedich-541	102	14	knowledgebase	knowledgebase	NOUN
biomedich-541	102	15	:	:	PUNCT
biomedich-541	102	16	how	how	SCONJ
biomedich-541	102	17	to	to	PART
biomedich-541	102	18	use	use	VERB
biomedich-541	102	19	the	the	DET
biomedich-541	102	20	entry	entry	NOUN
biomedich-541	102	21	view	view	NOUN
biomedich-541	102	22	.	.	PUNCT
biomedich-541	103	1	methods	method	NOUN
biomedich-541	103	2	in	in	ADP
biomedich-541	103	3	molecular	molecular	ADJ
biomedich-541	103	4	biology	biology	NOUN
biomedich-541	103	5	(	(	PUNCT
biomedich-541	103	6	clifton	clifton	PROPN
biomedich-541	103	7	,	,	PUNCT
biomedich-541	103	8	n.j	n.j	PROPN
biomedich-541	103	9	.	.	PROPN
biomedich-541	103	10	)	)	PUNCT
biomedich-541	103	11	,	,	PUNCT
biomedich-541	103	12	1374	1374	NUM
biomedich-541	103	13	,	,	PUNCT
biomedich-541	103	14	23–54	23–54	NUM
biomedich-541	103	15	.	.	PUNCT
biomedich-541	104	1	https://doi.org/10.1007/978-1-4939-3167-5_2	https://doi.org/10.1007/978-1-4939-3167-5_2	PROPN
biomedich-541	104	2	burley	burley	NOUN
biomedich-541	104	3	,	,	PUNCT
biomedich-541	104	4	s.	s.	PROPN
biomedich-541	104	5	k.	k.	PROPN
biomedich-541	104	6	,	,	PUNCT
biomedich-541	104	7	berman	berman	PROPN
biomedich-541	104	8	,	,	PUNCT
biomedich-541	104	9	h.	h.	PROPN
biomedich-541	104	10	m.	m.	PROPN
biomedich-541	104	11	,	,	PUNCT
biomedich-541	104	12	kleywegt	kleywegt	PROPN
biomedich-541	104	13	,	,	PUNCT
biomedich-541	104	14	g.	g.	PROPN
biomedich-541	104	15	j.	j.	PROPN
biomedich-541	104	16	,	,	PUNCT
biomedich-541	104	17	markley	markley	PROPN
biomedich-541	104	18	,	,	PUNCT
biomedich-541	104	19	j.	j.	PROPN
biomedich-541	104	20	l.	l.	PROPN
biomedich-541	104	21	,	,	PUNCT
biomedich-541	104	22	nakamura	nakamura	PROPN
biomedich-541	104	23	,	,	PUNCT
biomedich-541	104	24	h.	h.	PROPN
biomedich-541	104	25	,	,	PUNCT
biomedich-541	104	26	&	&	CCONJ
biomedich-541	104	27	velankar	velankar	PROPN
biomedich-541	104	28	,	,	PUNCT
biomedich-541	104	29	s.	s.	PROPN
biomedich-541	104	30	(	(	PUNCT
biomedich-541	104	31	2017	2017	NUM
biomedich-541	104	32	)	)	PUNCT
biomedich-541	104	33	.	.	PUNCT
biomedich-541	105	1	protein	protein	NOUN
biomedich-541	105	2	data	data	PROPN
biomedich-541	105	3	bank	bank	PROPN
biomedich-541	105	4	(	(	PUNCT
biomedich-541	105	5	pdb	pdb	PROPN
biomedich-541	105	6	):	):	PUNCT
biomedich-541	105	7	the	the	DET
biomedich-541	105	8	single	single	ADJ
biomedich-541	105	9	global	global	ADJ
biomedich-541	105	10	macromolecular	macromolecular	PROPN
biomedich-541	105	11	structure	structure	NOUN
biomedich-541	105	12	archive	archive	NOUN
biomedich-541	105	13	.	.	PUNCT
biomedich-541	106	1	methods	method	NOUN
biomedich-541	106	2	in	in	ADP
biomedich-541	106	3	molecular	molecular	ADJ
biomedich-541	106	4	biology	biology	NOUN
biomedich-541	106	5	(	(	PUNCT
biomedich-541	106	6	clifton	clifton	PROPN
biomedich-541	106	7	,	,	PUNCT
biomedich-541	106	8	n.j	n.j	PROPN
biomedich-541	106	9	.	.	PROPN
biomedich-541	106	10	)	)	PUNCT
biomedich-541	106	11	,	,	PUNCT
biomedich-541	106	12	1607	1607	NUM
biomedich-541	106	13	,	,	PUNCT
biomedich-541	106	14	627–641	627–641	NUM
biomedich-541	106	15	.	.	PUNCT
biomedich-541	107	1	https://doi.org/10.1007/978-1-4939-7000-1_26	https://doi.org/10.1007/978-1-4939-7000-1_26	PROPN
biomedich-541	107	2	cavasotto	cavasotto	PROPN
biomedich-541	107	3	,	,	PUNCT
biomedich-541	107	4	c.	c.	PROPN
biomedich-541	107	5	n.	n.	PROPN
biomedich-541	107	6	,	,	PUNCT
biomedich-541	107	7	&	&	CCONJ
biomedich-541	107	8	phatak	phatak	PROPN
biomedich-541	107	9	,	,	PUNCT
biomedich-541	107	10	s.	s.	PROPN
biomedich-541	107	11	s.	s.	PROPN
biomedich-541	107	12	(	(	PUNCT
biomedich-541	107	13	2009	2009	NUM
biomedich-541	107	14	)	)	PUNCT
biomedich-541	107	15	.	.	PUNCT
biomedich-541	108	1	homology	homology	NOUN
biomedich-541	108	2	modeling	modeling	NOUN
biomedich-541	108	3	in	in	ADP
biomedich-541	108	4	drug	drug	NOUN
biomedich-541	108	5	discovery	discovery	NOUN
biomedich-541	108	6	:	:	PUNCT
biomedich-541	108	7	current	current	ADJ
biomedich-541	108	8	trends	trend	NOUN
biomedich-541	108	9	and	and	CCONJ
biomedich-541	108	10	applications	application	NOUN
biomedich-541	108	11	.	.	PUNCT
biomedich-541	109	1	drug	drug	NOUN
biomedich-541	109	2	discovery	discovery	PROPN
biomedich-541	109	3	today	today	NOUN
biomedich-541	109	4	,	,	PUNCT
biomedich-541	109	5	14(13	14(13	NUM
biomedich-541	109	6	-	-	SYM
biomedich-541	109	7	14	14	NUM
biomedich-541	109	8	)	)	PUNCT
biomedich-541	109	9	,	,	PUNCT
biomedich-541	109	10	676–683	676–683	NUM
biomedich-541	109	11	.	.	PUNCT
biomedich-541	110	1	https://doi.org/10.1016/j.drudis.2009.04.006	https://doi.org/10.1016/j.drudis.2009.04.006	NOUN
biomedich-541	110	2	danser	danser	NOUN
biomedich-541	110	3	,	,	PUNCT
biomedich-541	110	4	a.	a.	PROPN
biomedich-541	110	5	h.	h.	PROPN
biomedich-541	110	6	j.	j.	PROPN
biomedich-541	110	7	,	,	PUNCT
biomedich-541	110	8	epstein	epstein	PROPN
biomedich-541	110	9	,	,	PUNCT
biomedich-541	110	10	m.	m.	NOUN
biomedich-541	110	11	,	,	PUNCT
biomedich-541	110	12	&	&	CCONJ
biomedich-541	110	13	batlle	batlle	PROPN
biomedich-541	110	14	,	,	PUNCT
biomedich-541	110	15	d.	d.	PROPN
biomedich-541	110	16	(	(	PUNCT
biomedich-541	110	17	2020	2020	NUM
biomedich-541	110	18	)	)	PUNCT
biomedich-541	110	19	.	.	PUNCT
biomedich-541	111	1	reninangiotensin	reninangiotensin	NOUN
biomedich-541	111	2	system	system	NOUN
biomedich-541	111	3	blockers	blocker	NOUN
biomedich-541	111	4	and	and	CCONJ
biomedich-541	111	5	the	the	DET
biomedich-541	111	6	covid-19	covid-19	PROPN
biomedich-541	111	7	pandemic	pandemic	NOUN
biomedich-541	111	8	:	:	PUNCT
biomedich-541	111	9	at	at	ADP
biomedich-541	111	10	present	present	NOUN
biomedich-541	111	11	there	there	PRON
biomedich-541	111	12	is	be	VERB
biomedich-541	111	13	no	no	DET
biomedich-541	111	14	evidence	evidence	NOUN
biomedich-541	111	15	to	to	PART
biomedich-541	111	16	abandon	abandon	VERB
biomedich-541	111	17	reninangiotensin	reninangiotensin	NOUN
biomedich-541	111	18	system	system	NOUN
biomedich-541	111	19	blockers	blocker	NOUN
biomedich-541	111	20	.	.	PUNCT
biomedich-541	112	1	hypertension	hypertension	NOUN
biomedich-541	112	2	(	(	PUNCT
biomedich-541	112	3	dallas	dallas	PROPN
biomedich-541	112	4	,	,	PUNCT
biomedich-541	112	5	tex	tex	PROPN
biomedich-541	112	6	.	.	PROPN
biomedich-541	112	7	:	:	PUNCT
biomedich-541	112	8	1979	1979	NUM
biomedich-541	112	9	)	)	PUNCT
biomedich-541	112	10	,	,	PUNCT
biomedich-541	112	11	75(6	75(6	NUM
biomedich-541	112	12	)	)	PUNCT
biomedich-541	112	13	,	,	PUNCT
biomedich-541	112	14	1382–1385	1382–1385	NUM
biomedich-541	112	15	.	.	PUNCT
biomedich-541	113	1	https://doi.org/10.1161/hypertensionaha.120.15082	https://doi.org/10.1161/hypertensionaha.120.15082	PROPN
biomedich-541	113	2	dutta	dutta	PROPN
biomedich-541	113	3	k.	k.	PROPN
biomedich-541	113	4	(	(	PUNCT
biomedich-541	113	5	2022	2022	NUM
biomedich-541	113	6	)	)	PUNCT
biomedich-541	113	7	.	.	PUNCT
biomedich-541	114	1	allosteric	allosteric	ADJ
biomedich-541	114	2	site	site	NOUN
biomedich-541	114	3	of	of	ADP
biomedich-541	114	4	ace-2	ace-2	PUNCT
biomedich-541	114	5	as	as	ADP
biomedich-541	114	6	a	a	DET
biomedich-541	114	7	drug	drug	NOUN
biomedich-541	114	8	target	target	NOUN
biomedich-541	114	9	for	for	ADP
biomedich-541	114	10	covid-19	covid-19	PROPN
biomedich-541	114	11	.	.	PUNCT
biomedich-541	114	12	acs	acs	PROPN
biomedich-541	114	13	pharmacology	pharmacology	PROPN
biomedich-541	114	14	&	&	CCONJ
biomedich-541	114	15	translational	translational	ADJ
biomedich-541	114	16	science	science	NOUN
biomedich-541	114	17	,	,	PUNCT
biomedich-541	114	18	5(3	5(3	NUM
biomedich-541	114	19	)	)	PUNCT
biomedich-541	114	20	,	,	PUNCT
biomedich-541	114	21	179–182	179–182	NUM
biomedich-541	114	22	.	.	PUNCT
biomedich-541	115	1	https://doi.org/10.1021/acsptsci.2c00003	https://doi.org/10.1021/acsptsci.2c00003	ADJ
biomedich-541	115	2	güner	güner	NOUN
biomedich-541	115	3	,	,	PUNCT
biomedich-541	115	4	o.	o.	PROPN
biomedich-541	115	5	f.	f.	PROPN
biomedich-541	115	6	,	,	PUNCT
biomedich-541	115	7	&	&	CCONJ
biomedich-541	115	8	bowen	bowen	PROPN
biomedich-541	115	9	,	,	PUNCT
biomedich-541	115	10	j.	j.	PROPN
biomedich-541	115	11	p.	p.	PROPN
biomedich-541	115	12	(	(	PUNCT
biomedich-541	115	13	2014	2014	NUM
biomedich-541	115	14	)	)	PUNCT
biomedich-541	115	15	.	.	PUNCT
biomedich-541	116	1	setting	set	VERB
biomedich-541	116	2	the	the	DET
biomedich-541	116	3	record	record	NOUN
biomedich-541	116	4	straight	straight	ADV
biomedich-541	116	5	:	:	PUNCT
biomedich-541	116	6	the	the	DET
biomedich-541	116	7	origin	origin	NOUN
biomedich-541	116	8	of	of	ADP
biomedich-541	116	9	the	the	DET
biomedich-541	116	10	pharmacophore	pharmacophore	NOUN
biomedich-541	116	11	concept	concept	NOUN
biomedich-541	116	12	.	.	PUNCT
biomedich-541	117	1	journal	journal	PROPN
biomedich-541	117	2	of	of	ADP
biomedich-541	117	3	chemical	chemical	ADJ
biomedich-541	117	4	information	information	NOUN
biomedich-541	117	5	and	and	CCONJ
biomedich-541	117	6	modeling	modeling	NOUN
biomedich-541	117	7	,	,	PUNCT
biomedich-541	117	8	54(5	54(5	NUM
biomedich-541	117	9	)	)	PUNCT
biomedich-541	117	10	,	,	PUNCT
biomedich-541	117	11	1269–1283	1269–1283	NUM
biomedich-541	117	12	.	.	PUNCT
biomedich-541	117	13	https://doi.org/10.1021/ci5000533	https://doi.org/10.1021/ci5000533	PROPN
biomedich-541	118	1	kai	kai	PROPN
biomedich-541	118	2	,	,	PUNCT
biomedich-541	118	3	h.	h.	PROPN
biomedich-541	118	4	,	,	PUNCT
biomedich-541	118	5	&	&	CCONJ
biomedich-541	118	6	kai	kai	PROPN
biomedich-541	118	7	,	,	PUNCT
biomedich-541	118	8	m.	m.	NOUN
biomedich-541	118	9	(	(	PUNCT
biomedich-541	118	10	2020	2020	NUM
biomedich-541	118	11	)	)	PUNCT
biomedich-541	118	12	.	.	PUNCT
biomedich-541	119	1	interactions	interaction	NOUN
biomedich-541	119	2	of	of	ADP
biomedich-541	119	3	coronaviruses	coronaviruse	NOUN
biomedich-541	119	4	with	with	ADP
biomedich-541	119	5	ace2	ace2	PROPN
biomedich-541	119	6	,	,	PUNCT
biomedich-541	119	7	angiotensin	angiotensin	NOUN
biomedich-541	119	8	ii	ii	PROPN
biomedich-541	119	9	,	,	PUNCT
biomedich-541	119	10	and	and	CCONJ
biomedich-541	119	11	ras	ras	X
biomedich-541	119	12	inhibitors	inhibitor	NOUN
biomedich-541	119	13	-	-	PUNCT
biomedich-541	119	14	lessons	lesson	NOUN
biomedich-541	119	15	from	from	ADP
biomedich-541	119	16	available	available	ADJ
biomedich-541	119	17	evidence	evidence	NOUN
biomedich-541	119	18	and	and	CCONJ
biomedich-541	119	19	insights	insight	NOUN
biomedich-541	119	20	into	into	ADP
biomedich-541	119	21	covid-19	covid-19	PROPN
biomedich-541	119	22	.	.	PUNCT
biomedich-541	119	23	hypertension	hypertension	NOUN
biomedich-541	119	24	research	research	PROPN
biomedich-541	119	25	:	:	PUNCT
biomedich-541	119	26	official	official	ADJ
biomedich-541	119	27	journal	journal	NOUN
biomedich-541	119	28	of	of	ADP
biomedich-541	119	29	the	the	DET
biomedich-541	119	30	japanese	japanese	ADJ
biomedich-541	119	31	society	society	NOUN
biomedich-541	119	32	of	of	ADP
biomedich-541	119	33	hypertension	hypertension	NOUN
biomedich-541	119	34	,	,	PUNCT
biomedich-541	119	35	43(7	43(7	NUM
biomedich-541	119	36	)	)	PUNCT
biomedich-541	119	37	,	,	PUNCT
biomedich-541	119	38	648–654	648–654	NUM
biomedich-541	119	39	.	.	PUNCT
biomedich-541	120	1	https://doi.org/10.1038/s41440020-0455-8	https://doi.org/10.1038/s41440020-0455-8	PROPN
biomedich-541	120	2	messerli	messerli	PROPN
biomedich-541	120	3	,	,	PUNCT
biomedich-541	120	4	f.	f.	PROPN
biomedich-541	120	5	h.	h.	PROPN
biomedich-541	120	6	,	,	PUNCT
biomedich-541	120	7	bangalore	bangalore	PROPN
biomedich-541	120	8	,	,	PUNCT
biomedich-541	120	9	s.	s.	PROPN
biomedich-541	120	10	,	,	PUNCT
biomedich-541	120	11	bavishi	bavishi	PROPN
biomedich-541	120	12	,	,	PUNCT
biomedich-541	120	13	c.	c.	PROPN
biomedich-541	120	14	,	,	PUNCT
biomedich-541	120	15	&	&	CCONJ
biomedich-541	120	16	rimoldi	rimoldi	PROPN
biomedich-541	120	17	,	,	PUNCT
biomedich-541	120	18	s.	s.	PROPN
biomedich-541	120	19	f.	f.	PROPN
biomedich-541	120	20	(	(	PUNCT
biomedich-541	120	21	2018	2018	NUM
biomedich-541	120	22	)	)	PUNCT
biomedich-541	120	23	.	.	PUNCT
biomedich-541	121	1	angiotensin	angiotensin	NOUN
biomedich-541	121	2	-	-	PUNCT
biomedich-541	121	3	converting	convert	VERB
biomedich-541	121	4	enzyme	enzyme	NOUN
biomedich-541	121	5	inhibitors	inhibitor	NOUN
biomedich-541	121	6	in	in	ADP
biomedich-541	121	7	hypertension	hypertension	NOUN
biomedich-541	121	8	:	:	PUNCT
biomedich-541	121	9	to	to	PART
biomedich-541	121	10	use	use	VERB
biomedich-541	121	11	or	or	CCONJ
biomedich-541	121	12	not	not	PART
biomedich-541	121	13	to	to	ADP
biomedich-541	121	14	use?.journal	use?.journal	ADJ
biomedich-541	121	15	of	of	ADP
biomedich-541	121	16	the	the	DET
biomedich-541	121	17	american	american	PROPN
biomedich-541	121	18	college	college	PROPN
biomedich-541	121	19	of	of	ADP
biomedich-541	121	20	cardiology	cardiology	NOUN
biomedich-541	121	21	,	,	PUNCT
biomedich-541	121	22	71(13	71(13	NUM
biomedich-541	121	23	)	)	PUNCT
biomedich-541	121	24	,	,	PUNCT
biomedich-541	121	25	1474–1482	1474–1482	NUM
biomedich-541	121	26	.	.	PUNCT
biomedich-541	122	1	https://doi.org/10.1016/j.jacc.2018.01.058	https://doi.org/10.1016/j.jacc.2018.01.058	PROPN
biomedich-541	122	2	molecular	molecular	ADJ
biomedich-541	122	3	operating	operating	NOUN
biomedich-541	122	4	environment	environment	NOUN
biomedich-541	122	5	(	(	PUNCT
biomedich-541	122	6	moe	moe	NOUN
biomedich-541	122	7	)	)	PUNCT
biomedich-541	122	8	,	,	PUNCT
biomedich-541	122	9	2022.02	2022.02	NUM
biomedich-541	122	10	chemical	chemical	NOUN
biomedich-541	122	11	computing	computing	PROPN
biomedich-541	122	12	group	group	NOUN
biomedich-541	122	13	ulc	ulc	PROPN
biomedich-541	122	14	,	,	PUNCT
biomedich-541	122	15	910	910	PROPN
biomedich-541	122	16	-	-	SYM
biomedich-541	122	17	1010	1010	NUM
biomedich-541	122	18	sherbrooke	sherbrooke	PROPN
biomedich-541	122	19	st	st	PROPN
biomedich-541	122	20	.	.	PROPN
biomedich-541	122	21	w.	w.	PROPN
biomedich-541	122	22	,	,	PUNCT
biomedich-541	122	23	montreal	montreal	PROPN
biomedich-541	122	24	,	,	PUNCT
biomedich-541	122	25	qc	qc	PROPN
biomedich-541	122	26	h3a	h3a	X
biomedich-541	122	27	2r7	2r7	PROPN
biomedich-541	122	28	,	,	PUNCT
biomedich-541	122	29	canada	canada	PROPN
biomedich-541	122	30	.	.	PUNCT
biomedich-541	123	1	natesh	natesh	PROPN
biomedich-541	123	2	,	,	PUNCT
biomedich-541	123	3	r.	r.	PROPN
biomedich-541	123	4	,	,	PUNCT
biomedich-541	123	5	schwager	schwager	NOUN
biomedich-541	123	6	,	,	PUNCT
biomedich-541	123	7	s.	s.	PROPN
biomedich-541	123	8	l.	l.	PROPN
biomedich-541	123	9	,	,	PUNCT
biomedich-541	123	10	evans	evans	PROPN
biomedich-541	123	11	,	,	PUNCT
biomedich-541	123	12	h.	h.	PROPN
biomedich-541	123	13	r.	r.	PROPN
biomedich-541	123	14	,	,	PUNCT
biomedich-541	123	15	sturrock	sturrock	NOUN
biomedich-541	123	16	,	,	PUNCT
biomedich-541	123	17	e.	e.	PROPN
biomedich-541	123	18	d.	d.	PROPN
biomedich-541	123	19	,	,	PUNCT
biomedich-541	123	20	&	&	CCONJ
biomedich-541	123	21	acharya	acharya	PROPN
biomedich-541	123	22	,	,	PUNCT
biomedich-541	123	23	k.	k.	PROPN
biomedich-541	123	24	r.	r.	PROPN
biomedich-541	123	25	(	(	PUNCT
biomedich-541	123	26	2004	2004	NUM
biomedich-541	123	27	)	)	PUNCT
biomedich-541	123	28	.	.	PUNCT
biomedich-541	124	1	structural	structural	ADJ
biomedich-541	124	2	details	detail	NOUN
biomedich-541	124	3	on	on	ADP
biomedich-541	124	4	the	the	DET
biomedich-541	124	5	binding	binding	NOUN
biomedich-541	124	6	of	of	ADP
biomedich-541	124	7	antihypertensive	antihypertensive	ADJ
biomedich-541	124	8	drugs	drug	NOUN
biomedich-541	124	9	captopril	captopril	NOUN
biomedich-541	124	10	and	and	CCONJ
biomedich-541	124	11	enalaprilat	enalaprilat	NOUN
biomedich-541	124	12	to	to	ADP
biomedich-541	124	13	human	human	ADJ
biomedich-541	124	14	testicular	testicular	ADJ
biomedich-541	124	15	angiotensin	angiotensin	NOUN
biomedich-541	124	16	i	i	PRON
biomedich-541	124	17	-	-	PUNCT
biomedich-541	124	18	converting	convert	VERB
biomedich-541	124	19	enzyme	enzyme	NOUN
biomedich-541	124	20	.	.	PUNCT
biomedich-541	125	1	biochemistry	biochemistry	NOUN
biomedich-541	125	2	,	,	PUNCT
biomedich-541	125	3	43(27	43(27	NUM
biomedich-541	125	4	)	)	PUNCT
biomedich-541	125	5	,	,	PUNCT
biomedich-541	125	6	8718–8724	8718–8724	NUM
biomedich-541	125	7	.	.	PUNCT
biomedich-541	126	1	https://doi.org/10.1021/bi049480n	https://doi.org/10.1021/bi049480n	PROPN
biomedich-541	126	2	natesh	natesh	NOUN
biomedich-541	126	3	,	,	PUNCT
biomedich-541	126	4	r.	r.	PROPN
biomedich-541	126	5	,	,	PUNCT
biomedich-541	126	6	schwager	schwager	NOUN
biomedich-541	126	7	,	,	PUNCT
biomedich-541	126	8	s.	s.	PROPN
biomedich-541	126	9	l.	l.	PROPN
biomedich-541	126	10	,	,	PUNCT
biomedich-541	126	11	sturrock	sturrock	NOUN
biomedich-541	126	12	,	,	PUNCT
biomedich-541	126	13	e.	e.	PROPN
biomedich-541	126	14	d.	d.	PROPN
biomedich-541	126	15	,	,	PUNCT
biomedich-541	126	16	&	&	CCONJ
biomedich-541	126	17	acharya	acharya	PROPN
biomedich-541	126	18	,	,	PUNCT
biomedich-541	126	19	k.	k.	PROPN
biomedich-541	126	20	r.	r.	PROPN
biomedich-541	126	21	(	(	PUNCT
biomedich-541	126	22	2003	2003	NUM
biomedich-541	126	23	)	)	PUNCT
biomedich-541	126	24	.	.	PUNCT
biomedich-541	127	1	crystal	crystal	NOUN
biomedich-541	127	2	structure	structure	NOUN
biomedich-541	127	3	of	of	ADP
biomedich-541	127	4	the	the	DET
biomedich-541	127	5	human	human	ADJ
biomedich-541	127	6	angiotensin	angiotensin	NOUN
biomedich-541	127	7	-	-	PUNCT
biomedich-541	127	8	converting	convert	VERB
biomedich-541	127	9	enzyme	enzyme	NOUN
biomedich-541	127	10	-	-	PUNCT
biomedich-541	127	11	lisinopril	lisinopril	NOUN
biomedich-541	127	12	complex	complex	NOUN
biomedich-541	127	13	.	.	PUNCT
biomedich-541	128	1	nature	nature	NOUN
biomedich-541	128	2	,	,	PUNCT
biomedich-541	128	3	421(6922	421(6922	NUM
biomedich-541	128	4	)	)	PUNCT
biomedich-541	128	5	,	,	PUNCT
biomedich-541	128	6	551–554	551–554	NUM
biomedich-541	128	7	.	.	PUNCT
biomedich-541	129	1	https://doi.org/10.1038/nature01370	https://doi.org/10.1038/nature01370	PROPN
biomedich-541	129	2	https://doi.org/10.1155/2023/7890188	https://doi.org/10.1155/2023/7890188	PROPN
biomedich-541	129	3	https://doi.org/10.1007/978-1-4939-3167-5_2	https://doi.org/10.1007/978-1-4939-3167-5_2	PROPN
biomedich-541	129	4	https://doi.org/10.1007/978-1-4939-7000-1_26	https://doi.org/10.1007/978-1-4939-7000-1_26	NOUN
biomedich-541	129	5	ujiantari	ujiantari	PROPN
biomedich-541	129	6	&	&	CCONJ
biomedich-541	129	7	apsari	apsari	PROPN
biomedich-541	129	8	–	–	PUNCT
biomedich-541	129	9	pharmacophore	pharmacophore	NOUN
biomedich-541	129	10	mapping	mapping	NOUN
biomedich-541	129	11	of	of	ADP
biomedich-541	129	12	ace1	ace1	PROPN
biomedich-541	129	13	and	and	CCONJ
biomedich-541	129	14	ace2	ace2	PROPN
biomedich-541	129	15	341	341	NUM
biomedich-541	129	16	ni	ni	PROPN
biomedich-541	129	17	,	,	PUNCT
biomedich-541	129	18	w.	w.	PROPN
biomedich-541	129	19	,	,	PUNCT
biomedich-541	129	20	yang	yang	PROPN
biomedich-541	129	21	,	,	PUNCT
biomedich-541	129	22	x.	x.	PROPN
biomedich-541	129	23	,	,	PUNCT
biomedich-541	129	24	yang	yang	PROPN
biomedich-541	129	25	,	,	PUNCT
biomedich-541	129	26	d.	d.	PROPN
biomedich-541	129	27	,	,	PUNCT
biomedich-541	129	28	bao	bao	PROPN
biomedich-541	129	29	,	,	PUNCT
biomedich-541	129	30	j.	j.	PROPN
biomedich-541	129	31	,	,	PUNCT
biomedich-541	129	32	li	li	PROPN
biomedich-541	129	33	,	,	PUNCT
biomedich-541	129	34	r.	r.	PROPN
biomedich-541	129	35	,	,	PUNCT
biomedich-541	129	36	xiao	xiao	PROPN
biomedich-541	129	37	,	,	PUNCT
biomedich-541	129	38	y.	y.	PROPN
biomedich-541	129	39	,	,	PUNCT
biomedich-541	129	40	hou	hou	PROPN
biomedich-541	129	41	,	,	PUNCT
biomedich-541	129	42	c.	c.	PROPN
biomedich-541	129	43	,	,	PUNCT
biomedich-541	129	44	wang	wang	PROPN
biomedich-541	129	45	,	,	PUNCT
biomedich-541	129	46	h.	h.	PROPN
biomedich-541	129	47	,	,	PUNCT
biomedich-541	129	48	liu	liu	PROPN
biomedich-541	129	49	,	,	PUNCT
biomedich-541	129	50	j.	j.	PROPN
biomedich-541	129	51	,	,	PUNCT
biomedich-541	129	52	yang	yang	PROPN
biomedich-541	129	53	,	,	PUNCT
biomedich-541	129	54	d.	d.	PROPN
biomedich-541	129	55	,	,	PUNCT
biomedich-541	129	56	xu	xu	PROPN
biomedich-541	129	57	,	,	PUNCT
biomedich-541	129	58	y.	y.	PROPN
biomedich-541	129	59	,	,	PUNCT
biomedich-541	129	60	cao	cao	PROPN
biomedich-541	129	61	,	,	PUNCT
biomedich-541	129	62	z.	z.	PROPN
biomedich-541	129	63	,	,	PUNCT
biomedich-541	129	64	&	&	CCONJ
biomedich-541	129	65	gao	gao	PROPN
biomedich-541	129	66	,	,	PUNCT
biomedich-541	129	67	z.	z.	PROPN
biomedich-541	129	68	(	(	PUNCT
biomedich-541	129	69	2020	2020	NUM
biomedich-541	129	70	)	)	PUNCT
biomedich-541	129	71	.	.	PUNCT
biomedich-541	130	1	role	role	NOUN
biomedich-541	130	2	of	of	ADP
biomedich-541	130	3	angiotensin	angiotensin	NOUN
biomedich-541	130	4	-	-	PUNCT
biomedich-541	130	5	converting	convert	VERB
biomedich-541	130	6	enzyme	enzyme	NOUN
biomedich-541	130	7	2	2	NUM
biomedich-541	130	8	(	(	PUNCT
biomedich-541	130	9	ace2	ace2	PROPN
biomedich-541	130	10	)	)	PUNCT
biomedich-541	130	11	in	in	ADP
biomedich-541	130	12	covid-19	covid-19	PROPN
biomedich-541	130	13	.	.	PUNCT
biomedich-541	131	1	critical	critical	ADJ
biomedich-541	131	2	care	care	NOUN
biomedich-541	131	3	(	(	PUNCT
biomedich-541	131	4	london	london	PROPN
biomedich-541	131	5	,	,	PUNCT
biomedich-541	131	6	england	england	PROPN
biomedich-541	131	7	)	)	PUNCT
biomedich-541	131	8	,	,	PUNCT
biomedich-541	131	9	24(1	24(1	NUM
biomedich-541	131	10	)	)	PUNCT
biomedich-541	131	11	,	,	PUNCT
biomedich-541	131	12	422	422	NUM
biomedich-541	131	13	.	.	PUNCT
biomedich-541	131	14	https://doi.org/10.1186/s13054-020-03120-0	https://doi.org/10.1186/s13054-020-03120-0	NUM
biomedich-541	131	15	pagliaro	pagliaro	NOUN
biomedich-541	131	16	,	,	PUNCT
biomedich-541	131	17	p.	p.	NOUN
biomedich-541	131	18	,	,	PUNCT
biomedich-541	131	19	thairi	thairi	NOUN
biomedich-541	131	20	,	,	PUNCT
biomedich-541	131	21	c.	c.	PROPN
biomedich-541	131	22	,	,	PUNCT
biomedich-541	131	23	alloatti	alloatti	PROPN
biomedich-541	131	24	,	,	PUNCT
biomedich-541	131	25	g.	g.	PROPN
biomedich-541	131	26	,	,	PUNCT
biomedich-541	131	27	&	&	CCONJ
biomedich-541	131	28	penna	penna	PROPN
biomedich-541	131	29	,	,	PUNCT
biomedich-541	131	30	c.	c.	PROPN
biomedich-541	131	31	(	(	PUNCT
biomedich-541	131	32	2022	2022	NUM
biomedich-541	131	33	)	)	PUNCT
biomedich-541	131	34	.	.	PUNCT
biomedich-541	132	1	angiotensin	angiotensin	NOUN
biomedich-541	132	2	-	-	PUNCT
biomedich-541	132	3	converting	convert	VERB
biomedich-541	132	4	enzyme	enzyme	NOUN
biomedich-541	132	5	2	2	NUM
biomedich-541	132	6	:	:	PUNCT
biomedich-541	132	7	a	a	DET
biomedich-541	132	8	key	key	ADJ
biomedich-541	132	9	enzyme	enzyme	NOUN
biomedich-541	132	10	in	in	ADP
biomedich-541	132	11	key	key	ADJ
biomedich-541	132	12	organs	organ	NOUN
biomedich-541	132	13	.	.	PUNCT
biomedich-541	132	14	journal	journal	NOUN
biomedich-541	132	15	of	of	ADP
biomedich-541	132	16	cardiovascular	cardiovascular	ADJ
biomedich-541	132	17	medicine	medicine	NOUN
biomedich-541	132	18	(	(	PUNCT
biomedich-541	132	19	hagerstown	hagerstown	PROPN
biomedich-541	132	20	,	,	PUNCT
biomedich-541	132	21	md	md	PROPN
biomedich-541	132	22	.	.	PROPN
biomedich-541	132	23	)	)	PUNCT
biomedich-541	132	24	,	,	PUNCT
biomedich-541	132	25	23(1	23(1	X
biomedich-541	132	26	)	)	PUNCT
biomedich-541	132	27	,	,	PUNCT
biomedich-541	132	28	1–11	1–11	PROPN
biomedich-541	132	29	.	.	PUNCT
biomedich-541	133	1	https://doi.org/10.2459/jcm.0000000000001218	https://doi.org/10.2459/jcm.0000000000001218	PROPN
biomedich-541	133	2	pearson	pearson	PROPN
biomedich-541	133	3	w.	w.	PROPN
biomedich-541	133	4	r.	r.	PROPN
biomedich-541	133	5	(	(	PUNCT
biomedich-541	133	6	2013	2013	NUM
biomedich-541	133	7	)	)	PUNCT
biomedich-541	133	8	.	.	PUNCT
biomedich-541	134	1	an	an	DET
biomedich-541	134	2	introduction	introduction	NOUN
biomedich-541	134	3	to	to	ADP
biomedich-541	134	4	sequence	sequence	NOUN
biomedich-541	134	5	similarity	similarity	NOUN
biomedich-541	134	6	(	(	PUNCT
biomedich-541	134	7	"	"	PUNCT
biomedich-541	134	8	homology	homology	NOUN
biomedich-541	134	9	"	"	PUNCT
biomedich-541	134	10	)	)	PUNCT
biomedich-541	134	11	searching	search	VERB
biomedich-541	134	12	.	.	PUNCT
biomedich-541	135	1	current	current	ADJ
biomedich-541	135	2	protocols	protocol	NOUN
biomedich-541	135	3	in	in	ADP
biomedich-541	135	4	bioinformatics	bioinformatics	NOUN
biomedich-541	135	5	,	,	PUNCT
biomedich-541	135	6	chapter	chapter	NOUN
biomedich-541	135	7	3	3	NUM
biomedich-541	135	8	,	,	PUNCT
biomedich-541	135	9	3.1.1–3.1.8	3.1.1–3.1.8	NUM
biomedich-541	135	10	.	.	PUNCT
biomedich-541	136	1	https://doi.org/10.1002/0471250953.bi0301s42	https://doi.org/10.1002/0471250953.bi0301s42	NOUN
biomedich-541	136	2	schaller	schaller	PROPN
biomedich-541	136	3	d	d	PROPN
biomedich-541	136	4	,	,	PUNCT
biomedich-541	136	5	šribar	šribar	PROPN
biomedich-541	136	6	d	d	PROPN
biomedich-541	136	7	,	,	PUNCT
biomedich-541	136	8	noonan	noonan	PROPN
biomedich-541	136	9	t	t	PROPN
biomedich-541	136	10	,	,	PUNCT
biomedich-541	136	11	(	(	PUNCT
biomedich-541	136	12	2020	2020	NUM
biomedich-541	136	13	)	)	PUNCT
biomedich-541	137	1	next	next	ADJ
biomedich-541	137	2	generation	generation	NOUN
biomedich-541	137	3	3d	3d	NUM
biomedich-541	137	4	pharmacophore	pharmacophore	NOUN
biomedich-541	137	5	modeling	modeling	NOUN
biomedich-541	137	6	.	.	PUNCT
biomedich-541	138	1	wires	wire	NOUN
biomedich-541	138	2	comput	comput	VERB
biomedich-541	138	3	mol	mol	ADP
biomedich-541	138	4	sci	sci	PROPN
biomedich-541	138	5	.	.	PROPN
biomedich-541	138	6	2020	2020	NUM
biomedich-541	138	7	;	;	PUNCT
biomedich-541	139	1	10	10	NUM
biomedich-541	139	2	:	:	PUNCT
biomedich-541	139	3	e1468	e1468	NOUN
biomedich-541	139	4	.	.	PROPN
biomedich-541	139	5	https://doi.org/10.1002/wcms.1468	https://doi.org/10.1002/wcms.1468	PROPN
biomedich-541	139	6	seidel	seidel	PROPN
biomedich-541	139	7	,	,	PUNCT
biomedich-541	139	8	t.	t.	PROPN
biomedich-541	139	9	,	,	PUNCT
biomedich-541	139	10	wolber	wolber	NOUN
biomedich-541	139	11	,	,	PUNCT
biomedich-541	139	12	g.	g.	PROPN
biomedich-541	139	13	,	,	PUNCT
biomedich-541	139	14	&	&	CCONJ
biomedich-541	139	15	murgueitio	murgueitio	PROPN
biomedich-541	139	16	,	,	PUNCT
biomedich-541	139	17	m.s	m.s	PROPN
biomedich-541	139	18	.	.	PROPN
biomedich-541	139	19	(	(	PUNCT
biomedich-541	139	20	2018	2018	NUM
biomedich-541	139	21	)	)	PUNCT
biomedich-541	139	22	applied	apply	VERB
biomedich-541	139	23	chemoinformatics	chemoinformatic	NOUN
biomedich-541	139	24	.	.	PUNCT
biomedich-541	139	25	weinheim	weinheim	PROPN
biomedich-541	139	26	:	:	PUNCT
biomedich-541	139	27	wiley	wiley	PROPN
biomedich-541	139	28	vch	vch	PROPN
biomedich-541	139	29	.	.	PUNCT
biomedich-541	139	30	towler	towler	PROPN
biomedich-541	139	31	,	,	PUNCT
biomedich-541	139	32	p.	p.	NOUN
biomedich-541	139	33	,	,	PUNCT
biomedich-541	139	34	staker	staker	NOUN
biomedich-541	139	35	,	,	PUNCT
biomedich-541	139	36	b.	b.	PROPN
biomedich-541	139	37	,	,	PUNCT
biomedich-541	139	38	prasad	prasad	PROPN
biomedich-541	139	39	,	,	PUNCT
biomedich-541	139	40	s.	s.	PROPN
biomedich-541	139	41	g.	g.	PROPN
biomedich-541	139	42	,	,	PUNCT
biomedich-541	139	43	menon	menon	PROPN
biomedich-541	139	44	,	,	PUNCT
biomedich-541	139	45	s.	s.	PROPN
biomedich-541	139	46	,	,	PUNCT
biomedich-541	139	47	tang	tang	PROPN
biomedich-541	139	48	,	,	PUNCT
biomedich-541	139	49	j.	j.	PROPN
biomedich-541	139	50	,	,	PUNCT
biomedich-541	139	51	parsons	parson	NOUN
biomedich-541	139	52	,	,	PUNCT
biomedich-541	139	53	t.	t.	PROPN
biomedich-541	139	54	,	,	PUNCT
biomedich-541	139	55	ryan	ryan	PROPN
biomedich-541	139	56	,	,	PUNCT
biomedich-541	139	57	d.	d.	PROPN
biomedich-541	139	58	,	,	PUNCT
biomedich-541	139	59	fisher	fisher	PROPN
biomedich-541	139	60	,	,	PUNCT
biomedich-541	139	61	m.	m.	NOUN
biomedich-541	139	62	,	,	PUNCT
biomedich-541	139	63	williams	williams	PROPN
biomedich-541	139	64	,	,	PUNCT
biomedich-541	139	65	d.	d.	PROPN
biomedich-541	139	66	,	,	PUNCT
biomedich-541	139	67	dales	dales	PROPN
biomedich-541	139	68	,	,	PUNCT
biomedich-541	139	69	n.	n.	PROPN
biomedich-541	139	70	a.	a.	NOUN
biomedich-541	139	71	,	,	PUNCT
biomedich-541	139	72	patane	patane	NOUN
biomedich-541	139	73	,	,	PUNCT
biomedich-541	139	74	m.	m.	NOUN
biomedich-541	139	75	a.	a.	PROPN
biomedich-541	139	76	,	,	PUNCT
biomedich-541	139	77	&	&	CCONJ
biomedich-541	139	78	pantoliano	pantoliano	PROPN
biomedich-541	139	79	,	,	PUNCT
biomedich-541	139	80	m.	m.	NOUN
biomedich-541	139	81	w.	w.	PROPN
biomedich-541	139	82	(	(	PUNCT
biomedich-541	139	83	2004	2004	NUM
biomedich-541	139	84	)	)	PUNCT
biomedich-541	139	85	.	.	PUNCT
biomedich-541	140	1	ace2	ace2	PROPN
biomedich-541	140	2	x	x	NOUN
biomedich-541	140	3	-	-	NOUN
biomedich-541	140	4	ray	ray	NOUN
biomedich-541	140	5	structures	structure	NOUN
biomedich-541	140	6	reveal	reveal	VERB
biomedich-541	140	7	a	a	DET
biomedich-541	140	8	large	large	ADJ
biomedich-541	140	9	hinge	hinge	NOUN
biomedich-541	140	10	-	-	PUNCT
biomedich-541	140	11	bending	bend	VERB
biomedich-541	140	12	motion	motion	NOUN
biomedich-541	140	13	important	important	ADJ
biomedich-541	140	14	for	for	ADP
biomedich-541	140	15	inhibitor	inhibitor	NOUN
biomedich-541	140	16	binding	bind	VERB
biomedich-541	140	17	and	and	CCONJ
biomedich-541	140	18	catalysis	catalysis	NOUN
biomedich-541	140	19	.	.	PUNCT
biomedich-541	141	1	the	the	DET
biomedich-541	141	2	journal	journal	NOUN
biomedich-541	141	3	of	of	ADP
biomedich-541	141	4	biological	biological	ADJ
biomedich-541	141	5	chemistry	chemistry	NOUN
biomedich-541	141	6	,	,	PUNCT
biomedich-541	141	7	279(17	279(17	NUM
biomedich-541	141	8	)	)	PUNCT
biomedich-541	141	9	,	,	PUNCT
biomedich-541	141	10	17996–18007	17996–18007	NUM
biomedich-541	141	11	.	.	PUNCT
biomedich-541	142	1	https://doi.org/10.1074/jbc.m311191200	https://doi.org/10.1074/jbc.m311191200	PROPN
biomedich-541	142	2	vuorinen	vuorinen	PROPN
biomedich-541	142	3	,	,	PUNCT
biomedich-541	142	4	a.	a.	PROPN
biomedich-541	142	5	,	,	PUNCT
biomedich-541	142	6	&	&	CCONJ
biomedich-541	142	7	schuster	schuster	PROPN
biomedich-541	142	8	,	,	PUNCT
biomedich-541	142	9	d.	d.	PROPN
biomedich-541	142	10	(	(	PUNCT
biomedich-541	142	11	2015	2015	NUM
biomedich-541	142	12	)	)	PUNCT
biomedich-541	142	13	.	.	PUNCT
biomedich-541	143	1	methods	method	NOUN
biomedich-541	143	2	for	for	ADP
biomedich-541	143	3	generating	generate	VERB
biomedich-541	143	4	and	and	CCONJ
biomedich-541	143	5	applying	apply	VERB
biomedich-541	143	6	pharmacophore	pharmacophore	NOUN
biomedich-541	143	7	models	model	NOUN
biomedich-541	143	8	as	as	ADP
biomedich-541	143	9	virtual	virtual	ADJ
biomedich-541	143	10	screening	screening	NOUN
biomedich-541	143	11	filters	filter	NOUN
biomedich-541	143	12	and	and	CCONJ
biomedich-541	143	13	for	for	ADP
biomedich-541	143	14	bioactivity	bioactivity	NOUN
biomedich-541	143	15	profiling	profiling	NOUN
biomedich-541	143	16	.	.	PUNCT
biomedich-541	144	1	methods	method	NOUN
biomedich-541	144	2	(	(	PUNCT
biomedich-541	144	3	san	san	PROPN
biomedich-541	144	4	diego	diego	PROPN
biomedich-541	144	5	,	,	PUNCT
biomedich-541	144	6	calif	calif	PROPN
biomedich-541	144	7	.	.	PROPN
biomedich-541	144	8	)	)	PUNCT
biomedich-541	144	9	,	,	PUNCT
biomedich-541	144	10	71	71	NUM
biomedich-541	144	11	,	,	PUNCT
biomedich-541	144	12	113–134	113–134	NUM
biomedich-541	144	13	.	.	PUNCT
biomedich-541	145	1	https://doi.org/10.1016/j.ymeth.2014.10.013	https://doi.org/10.1016/j.ymeth.2014.10.013	PROPN
biomedich-541	145	2	https://doi.org/10.2459/jcm.0000000000001218	https://doi.org/10.2459/jcm.0000000000001218	NOUN
biomedich-541	145	3	https://doi.org/10.1002/wcms.1468	https://doi.org/10.1002/wcms.1468	NOUN
biomedich-541	145	4	this	this	DET
biomedich-541	145	5	page	page	NOUN
biomedich-541	145	6	intentionally	intentionally	ADV
biomedich-541	145	7	left	leave	VERB
biomedich-541	145	8	blank	blank	ADV