id	sid	tid	token	lemma	pos
biomedich-578	1	1	biology	biology	NOUN
biomedich-578	1	2	,	,	PUNCT
biomedich-578	1	3	medicine	medicine	NOUN
biomedich-578	1	4	,	,	PUNCT
biomedich-578	1	5	&	&	CCONJ
biomedich-578	1	6	natural	natural	ADJ
biomedich-578	1	7	product	product	NOUN
biomedich-578	1	8	chemistry	chemistry	NOUN
biomedich-578	1	9	issn	issn	VERB
biomedich-578	1	10	2089	2089	NUM
biomedich-578	1	11	-	-	SYM
biomedich-578	1	12	6514	6514	NUM
biomedich-578	1	13	(	(	PUNCT
biomedich-578	1	14	paper	paper	NOUN
biomedich-578	1	15	)	)	PUNCT
biomedich-578	1	16	volume	volume	NOUN
biomedich-578	1	17	13	13	NUM
biomedich-578	1	18	,	,	PUNCT
biomedich-578	1	19	number	number	NOUN
biomedich-578	1	20	2	2	NUM
biomedich-578	1	21	,	,	PUNCT
biomedich-578	1	22	october	october	PROPN
biomedich-578	1	23	2024	2024	NUM
biomedich-578	1	24	|	|	ADV
biomedich-578	1	25	pages	page	NOUN
biomedich-578	1	26	:	:	PUNCT
biomedich-578	1	27	433	433	NUM
biomedich-578	1	28	-	-	SYM
biomedich-578	1	29	441	441	NUM
biomedich-578	1	30	|	|	ADV
biomedich-578	1	31	doi	doi	NOUN
biomedich-578	1	32	:	:	PUNCT
biomedich-578	1	33	10.14421	10.14421	NUM
biomedich-578	1	34	/	/	SYM
biomedich-578	1	35	biomedich.2024.132.433	biomedich.2024.132.433	NOUN
biomedich-578	1	36	-	-	PUNCT
biomedich-578	1	37	441	441	NUM
biomedich-578	1	38	issn	issn	PROPN
biomedich-578	1	39	2540	2540	NUM
biomedich-578	1	40	-	-	SYM
biomedich-578	1	41	9328	9328	NUM
biomedich-578	1	42	(	(	PUNCT
biomedich-578	1	43	online	online	ADJ
biomedich-578	1	44	)	)	PUNCT
biomedich-578	1	45	prospecting	prospect	VERB
biomedich-578	1	46	marine	marine	ADJ
biomedich-578	1	47	natural	natural	ADJ
biomedich-578	1	48	products	product	NOUN
biomedich-578	1	49	as	as	ADP
biomedich-578	1	50	the	the	DET
biomedich-578	1	51	disease	disease	NOUN
biomedich-578	1	52	-	-	PUNCT
biomedich-578	1	53	modifying	modify	VERB
biomedich-578	1	54	treatment	treatment	NOUN
biomedich-578	1	55	of	of	ADP
biomedich-578	1	56	alzheimer	alzheimer	PROPN
biomedich-578	1	57	’s	’s	PART
biomedich-578	1	58	diseases	disease	NOUN
biomedich-578	1	59	legis	legis	VERB
biomedich-578	1	60	ocktaviana	ocktaviana	ADJ
biomedich-578	1	61	saputri1	saputri1	NOUN
biomedich-578	1	62	,	,	PUNCT
biomedich-578	1	63	*	*	SYM
biomedich-578	1	64	,	,	PUNCT
biomedich-578	1	65	herpan	herpan	PROPN
biomedich-578	1	66	syafii	syafii	PROPN
biomedich-578	1	67	harahap2	harahap2	PROPN
biomedich-578	1	68	,	,	PUNCT
biomedich-578	1	69	arina	arina	PROPN
biomedich-578	1	70	windri	windri	PROPN
biomedich-578	1	71	rivarti3	rivarti3	PROPN
biomedich-578	1	72	,	,	PUNCT
biomedich-578	1	73	fitriannisa	fitriannisa	VERB
biomedich-578	1	74	faradina	faradina	NOUN
biomedich-578	1	75	zubaidi4	zubaidi4	PROPN
biomedich-578	2	1	1department	1department	NUM
biomedich-578	2	2	of	of	ADP
biomedich-578	2	3	pharmacology	pharmacology	NOUN
biomedich-578	2	4	;	;	PUNCT
biomedich-578	2	5	2department	2department	NUM
biomedich-578	2	6	of	of	ADP
biomedich-578	2	7	neurology	neurology	NOUN
biomedich-578	2	8	;	;	PUNCT
biomedich-578	2	9	3department	3department	NUM
biomedich-578	2	10	of	of	ADP
biomedich-578	2	11	physiology	physiology	NOUN
biomedich-578	2	12	;	;	PUNCT
biomedich-578	2	13	4biomedical	4biomedical	NUM
biomedich-578	2	14	department	department	NOUN
biomedich-578	2	15	,	,	PUNCT
biomedich-578	2	16	faculty	faculty	NOUN
biomedich-578	2	17	of	of	ADP
biomedich-578	2	18	medicine	medicine	NOUN
biomedich-578	2	19	and	and	CCONJ
biomedich-578	2	20	health	health	NOUN
biomedich-578	2	21	sciences	science	NOUN
biomedich-578	2	22	,	,	PUNCT
biomedich-578	2	23	universitas	universitas	PROPN
biomedich-578	2	24	mataram	mataram	PROPN
biomedich-578	2	25	,	,	PUNCT
biomedich-578	2	26	jl	jl	PROPN
biomedich-578	2	27	.	.	PROPN
biomedich-578	2	28	pemuda	pemuda	PROPN
biomedich-578	2	29	no	no	DET
biomedich-578	2	30	37	37	NUM
biomedich-578	2	31	kota	kota	PROPN
biomedich-578	2	32	mataram	mataram	PROPN
biomedich-578	2	33	83115	83115	NUM
biomedich-578	2	34	,	,	PUNCT
biomedich-578	2	35	indonesia	indonesia	PROPN
biomedich-578	2	36	.	.	PUNCT
biomedich-578	3	1	corresponding	correspond	VERB
biomedich-578	3	2	author	author	NOUN
biomedich-578	3	3	*	*	PROPN
biomedich-578	3	4	legisocktavia@unram.ac.id	legisocktavia@unram.ac.id	ADJ
biomedich-578	3	5	manuscript	manuscript	NOUN
biomedich-578	3	6	received	receive	VERB
biomedich-578	3	7	:	:	PUNCT
biomedich-578	3	8	15	15	NUM
biomedich-578	3	9	july	july	PROPN
biomedich-578	3	10	,	,	PUNCT
biomedich-578	3	11	2024	2024	NUM
biomedich-578	3	12	.	.	PUNCT
biomedich-578	4	1	revision	revision	NOUN
biomedich-578	4	2	accepted	accept	VERB
biomedich-578	4	3	:	:	PUNCT
biomedich-578	4	4	07	07	NUM
biomedich-578	4	5	october	october	PROPN
biomedich-578	4	6	,	,	PUNCT
biomedich-578	4	7	2024	2024	NUM
biomedich-578	4	8	.	.	PUNCT
biomedich-578	5	1	published	publish	VERB
biomedich-578	5	2	:	:	PUNCT
biomedich-578	5	3	10	10	NUM
biomedich-578	5	4	october	october	PROPN
biomedich-578	5	5	,	,	PUNCT
biomedich-578	5	6	2024	2024	NUM
biomedich-578	5	7	.	.	PUNCT
biomedich-578	6	1	abstract	abstract	PROPN
biomedich-578	6	2	alzheimer	alzheimer	PROPN
biomedich-578	6	3	's	's	PART
biomedich-578	6	4	disease	disease	NOUN
biomedich-578	6	5	(	(	PUNCT
biomedich-578	6	6	ad	ad	NOUN
biomedich-578	6	7	)	)	PUNCT
biomedich-578	6	8	is	be	AUX
biomedich-578	6	9	a	a	DET
biomedich-578	6	10	severe	severe	ADJ
biomedich-578	6	11	and	and	CCONJ
biomedich-578	6	12	high	high	ADJ
biomedich-578	6	13	costs	cost	NOUN
biomedich-578	6	14	health	health	NOUN
biomedich-578	6	15	problem	problem	NOUN
biomedich-578	6	16	all	all	ADV
biomedich-578	6	17	over	over	ADP
biomedich-578	6	18	the	the	DET
biomedich-578	6	19	world	world	NOUN
biomedich-578	6	20	.	.	PUNCT
biomedich-578	7	1	to	to	ADP
biomedich-578	7	2	date	date	NOUN
biomedich-578	7	3	,	,	PUNCT
biomedich-578	7	4	there	there	PRON
biomedich-578	7	5	is	be	VERB
biomedich-578	7	6	no	no	DET
biomedich-578	7	7	therapy	therapy	NOUN
biomedich-578	7	8	capable	capable	ADJ
biomedich-578	7	9	of	of	ADP
biomedich-578	7	10	curing	cure	VERB
biomedich-578	7	11	ad	ad	NOUN
biomedich-578	7	12	,	,	PUNCT
biomedich-578	7	13	making	make	VERB
biomedich-578	7	14	drug	drug	NOUN
biomedich-578	7	15	discovery	discovery	NOUN
biomedich-578	7	16	a	a	DET
biomedich-578	7	17	challenging	challenging	ADJ
biomedich-578	7	18	and	and	CCONJ
biomedich-578	7	19	intriguing	intriguing	ADJ
biomedich-578	7	20	field	field	NOUN
biomedich-578	7	21	to	to	PART
biomedich-578	7	22	explore	explore	VERB
biomedich-578	7	23	.	.	PUNCT
biomedich-578	8	1	targeting	target	VERB
biomedich-578	8	2	marine	marine	ADJ
biomedich-578	8	3	natural	natural	ADJ
biomedich-578	8	4	products	product	NOUN
biomedich-578	8	5	(	(	PUNCT
biomedich-578	8	6	mnps	mnps	PROPN
biomedich-578	8	7	)	)	PUNCT
biomedich-578	8	8	as	as	ADP
biomedich-578	8	9	a	a	DET
biomedich-578	8	10	source	source	NOUN
biomedich-578	8	11	of	of	ADP
biomedich-578	8	12	drug	drug	NOUN
biomedich-578	8	13	leads	lead	VERB
biomedich-578	8	14	is	be	AUX
biomedich-578	8	15	a	a	DET
biomedich-578	8	16	suitable	suitable	ADJ
biomedich-578	8	17	choice	choice	NOUN
biomedich-578	8	18	considering	consider	VERB
biomedich-578	8	19	the	the	DET
biomedich-578	8	20	content	content	NOUN
biomedich-578	8	21	of	of	ADP
biomedich-578	8	22	bioactive	bioactive	ADJ
biomedich-578	8	23	compounds	compound	NOUN
biomedich-578	8	24	and	and	CCONJ
biomedich-578	8	25	promising	promise	VERB
biomedich-578	8	26	pharmacological	pharmacological	NOUN
biomedich-578	8	27	benefits	benefit	NOUN
biomedich-578	8	28	.	.	PUNCT
biomedich-578	9	1	this	this	DET
biomedich-578	9	2	article	article	NOUN
biomedich-578	9	3	aims	aim	VERB
biomedich-578	9	4	to	to	PART
biomedich-578	9	5	look	look	VERB
biomedich-578	9	6	at	at	ADP
biomedich-578	9	7	mnps	mnps	NOUN
biomedich-578	9	8	with	with	ADP
biomedich-578	9	9	prospects	prospect	NOUN
biomedich-578	9	10	in	in	ADP
biomedich-578	9	11	several	several	ADJ
biomedich-578	9	12	prime	prime	ADJ
biomedich-578	9	13	targets	target	NOUN
biomedich-578	9	14	in	in	ADP
biomedich-578	9	15	ad	ad	NOUN
biomedich-578	9	16	pathology	pathology	NOUN
biomedich-578	9	17	to	to	PART
biomedich-578	9	18	cure	cure	VERB
biomedich-578	9	19	ad	ad	NOUN
biomedich-578	9	20	.	.	PUNCT
biomedich-578	10	1	marine	marine	ADJ
biomedich-578	10	2	vertebrates	vertebrate	NOUN
biomedich-578	10	3	(	(	PUNCT
biomedich-578	10	4	fishes	fish	NOUN
biomedich-578	10	5	)	)	PUNCT
biomedich-578	10	6	,	,	PUNCT
biomedich-578	10	7	marine	marine	NOUN
biomedich-578	10	8	invertebrates	invertebrate	NOUN
biomedich-578	10	9	(	(	PUNCT
biomedich-578	10	10	sponges	sponge	NOUN
biomedich-578	10	11	,	,	PUNCT
biomedich-578	10	12	tunicates	tunicate	NOUN
biomedich-578	10	13	,	,	PUNCT
biomedich-578	10	14	ascidian	ascidian	PROPN
biomedich-578	10	15	,	,	PUNCT
biomedich-578	10	16	clams	clams	PROPN
biomedich-578	10	17	,	,	PUNCT
biomedich-578	10	18	scallops	scallop	NOUN
biomedich-578	10	19	,	,	PUNCT
biomedich-578	10	20	sand	sand	NOUN
biomedich-578	10	21	dollars	dollar	NOUN
biomedich-578	10	22	,	,	PUNCT
biomedich-578	10	23	crabs	crab	NOUN
biomedich-578	10	24	,	,	PUNCT
biomedich-578	10	25	cockle	cockle	PROPN
biomedich-578	10	26	,	,	PUNCT
biomedich-578	10	27	sea	sea	NOUN
biomedich-578	10	28	cucumber	cucumber	NOUN
biomedich-578	10	29	,	,	PUNCT
biomedich-578	10	30	shrimp	shrimp	NOUN
biomedich-578	10	31	,	,	PUNCT
biomedich-578	10	32	bryozoa	bryozoan	NOUN
biomedich-578	10	33	,	,	PUNCT
biomedich-578	10	34	marine	marine	ADJ
biomedich-578	10	35	worm	worm	NOUN
biomedich-578	10	36	)	)	PUNCT
biomedich-578	10	37	,	,	PUNCT
biomedich-578	10	38	algae	algae	NOUN
biomedich-578	10	39	/	/	SYM
biomedich-578	10	40	seaweed	seaweed	NOUN
biomedich-578	10	41	,	,	PUNCT
biomedich-578	10	42	and	and	CCONJ
biomedich-578	10	43	marine	marine	ADJ
biomedich-578	10	44	microorganisms	microorganism	NOUN
biomedich-578	10	45	(	(	PUNCT
biomedich-578	10	46	marine	marine	ADJ
biomedich-578	10	47	fungi	fungi	PROPN
biomedich-578	10	48	,	,	PUNCT
biomedich-578	10	49	bacterium	bacterium	NOUN
biomedich-578	10	50	,	,	PUNCT
biomedich-578	10	51	dinoflagellata	dinoflagellata	NOUN
biomedich-578	10	52	,	,	PUNCT
biomedich-578	10	53	microalgae	microalgae	NOUN
biomedich-578	10	54	)	)	PUNCT
biomedich-578	10	55	can	can	AUX
biomedich-578	10	56	be	be	AUX
biomedich-578	10	57	potentially	potentially	ADV
biomedich-578	10	58	used	use	VERB
biomedich-578	10	59	as	as	ADP
biomedich-578	10	60	disease	disease	NOUN
biomedich-578	10	61	-	-	PUNCT
biomedich-578	10	62	modifying	modify	VERB
biomedich-578	10	63	treatments	treatment	NOUN
biomedich-578	10	64	(	(	PUNCT
biomedich-578	10	65	dmts	dmts	PROPN
biomedich-578	10	66	)	)	PUNCT
biomedich-578	10	67	for	for	ADP
biomedich-578	10	68	ad	ad	NOUN
biomedich-578	10	69	.	.	PUNCT
biomedich-578	11	1	by	by	ADP
biomedich-578	11	2	targeting	target	VERB
biomedich-578	11	3	multiple	multiple	ADJ
biomedich-578	11	4	aspects	aspect	NOUN
biomedich-578	11	5	of	of	ADP
biomedich-578	11	6	ad	ad	NOUN
biomedich-578	11	7	pathology	pathology	NOUN
biomedich-578	11	8	,	,	PUNCT
biomedich-578	11	9	these	these	DET
biomedich-578	11	10	mnps	mnps	NOUN
biomedich-578	11	11	offer	offer	VERB
biomedich-578	11	12	a	a	DET
biomedich-578	11	13	multifaceted	multifaceted	ADJ
biomedich-578	11	14	approach	approach	NOUN
biomedich-578	11	15	to	to	ADP
biomedich-578	11	16	treating	treat	VERB
biomedich-578	11	17	and	and	CCONJ
biomedich-578	11	18	potentially	potentially	ADV
biomedich-578	11	19	modifying	modify	VERB
biomedich-578	11	20	the	the	DET
biomedich-578	11	21	disease	disease	NOUN
biomedich-578	11	22	course	course	NOUN
biomedich-578	11	23	.	.	PUNCT
biomedich-578	12	1	this	this	DET
biomedich-578	12	2	result	result	NOUN
biomedich-578	12	3	is	be	AUX
biomedich-578	12	4	an	an	DET
biomedich-578	12	5	intriguing	intriguing	ADJ
biomedich-578	12	6	gap	gap	NOUN
biomedich-578	12	7	for	for	ADP
biomedich-578	12	8	researchers	researcher	NOUN
biomedich-578	12	9	in	in	ADP
biomedich-578	12	10	the	the	DET
biomedich-578	12	11	discovery	discovery	NOUN
biomedich-578	12	12	and	and	CCONJ
biomedich-578	12	13	development	development	NOUN
biomedich-578	12	14	of	of	ADP
biomedich-578	12	15	new	new	ADJ
biomedich-578	12	16	drugs	drug	NOUN
biomedich-578	12	17	that	that	PRON
biomedich-578	12	18	can	can	AUX
biomedich-578	12	19	improve	improve	VERB
biomedich-578	12	20	ad	ad	NOUN
biomedich-578	12	21	pathology	pathology	NOUN
biomedich-578	12	22	.	.	PUNCT
biomedich-578	13	1	keywords	keyword	NOUN
biomedich-578	13	2	:	:	PUNCT
biomedich-578	13	3	alzheimer	alzheimer	PROPN
biomedich-578	13	4	’s	’s	PART
biomedich-578	13	5	disease	disease	NOUN
biomedich-578	13	6	;	;	PUNCT
biomedich-578	13	7	marine	marine	ADJ
biomedich-578	13	8	;	;	PUNCT
biomedich-578	13	9	natural	natural	ADJ
biomedich-578	13	10	products	product	NOUN
biomedich-578	13	11	;	;	PUNCT
biomedich-578	13	12	drug	drug	NOUN
biomedich-578	13	13	lead	lead	NOUN
biomedich-578	13	14	;	;	PUNCT
biomedich-578	13	15	treatment	treatment	NOUN
biomedich-578	13	16	.	.	PUNCT
biomedich-578	14	1	abbreviations	abbreviation	NOUN
biomedich-578	14	2	:	:	PUNCT
biomedich-578	14	3	aβ	aβ	X
biomedich-578	14	4	:	:	PUNCT
biomedich-578	14	5	amyloid	amyloid	NOUN
biomedich-578	14	6	β	β	X
biomedich-578	14	7	;	;	PUNCT
biomedich-578	14	8	acheis	acheis	NOUN
biomedich-578	14	9	:	:	PUNCT
biomedich-578	14	10	acetylcholinesterase	acetylcholinesterase	NOUN
biomedich-578	14	11	inhibitors	inhibitor	NOUN
biomedich-578	14	12	;	;	PUNCT
biomedich-578	14	13	ad	ad	NOUN
biomedich-578	14	14	:	:	PUNCT
biomedich-578	14	15	alzheimer	alzheimer	PROPN
biomedich-578	14	16	’s	’s	PART
biomedich-578	14	17	disease	disease	NOUN
biomedich-578	14	18	;	;	PUNCT
biomedich-578	14	19	ages	age	NOUN
biomedich-578	14	20	:	:	PUNCT
biomedich-578	14	21	advanced	advanced	ADJ
biomedich-578	14	22	glycation	glycation	NOUN
biomedich-578	14	23	endproducts	endproduct	NOUN
biomedich-578	14	24	;	;	PUNCT
biomedich-578	14	25	app	app	NUM
biomedich-578	14	26	:	:	PUNCT
biomedich-578	14	27	amyloid	amyloid	NOUN
biomedich-578	14	28	protein	protein	NOUN
biomedich-578	14	29	precursor	precursor	NOUN
biomedich-578	14	30	;	;	PUNCT
biomedich-578	14	31	apoe-4	apoe-4	PROPN
biomedich-578	14	32	:	:	PUNCT
biomedich-578	14	33	apolipoprotein	apolipoprotein	ADJ
biomedich-578	14	34	e4	e4	PROPN
biomedich-578	14	35	;	;	PUNCT
biomedich-578	14	36	bace-1	bace-1	PROPN
biomedich-578	14	37	:	:	PUNCT
biomedich-578	14	38	β	β	X
biomedich-578	14	39	-	-	ADJ
biomedich-578	14	40	secretase	secretase	ADJ
biomedich-578	14	41	enzyme	enzyme	NOUN
biomedich-578	14	42	;	;	PUNCT
biomedich-578	14	43	bche	bche	NOUN
biomedich-578	14	44	:	:	PUNCT
biomedich-578	14	45	butyrylcholinesterase	butyrylcholinesterase	NOUN
biomedich-578	14	46	;	;	PUNCT
biomedich-578	14	47	cns	cns	NOUN
biomedich-578	14	48	:	:	PUNCT
biomedich-578	14	49	central	central	ADJ
biomedich-578	14	50	nervous	nervous	ADJ
biomedich-578	14	51	system	system	NOUN
biomedich-578	14	52	;	;	PUNCT
biomedich-578	14	53	dmts	dmts	NOUN
biomedich-578	14	54	:	:	PUNCT
biomedich-578	14	55	disease	disease	NOUN
biomedich-578	14	56	-	-	PUNCT
biomedich-578	14	57	modifying	modify	VERB
biomedich-578	14	58	treatments	treatment	NOUN
biomedich-578	14	59	;	;	PUNCT
biomedich-578	14	60	fda	fda	PROPN
biomedich-578	14	61	:	:	PUNCT
biomedich-578	14	62	food	food	NOUN
biomedich-578	14	63	and	and	CCONJ
biomedich-578	14	64	drug	drug	NOUN
biomedich-578	14	65	administration	administration	NOUN
biomedich-578	14	66	;	;	PUNCT
biomedich-578	14	67	gsk-3β	gsk-3β	PROPN
biomedich-578	14	68	:	:	PUNCT
biomedich-578	14	69	glycogen	glycogen	NOUN
biomedich-578	14	70	synthase	synthase	NOUN
biomedich-578	14	71	kinase	kinase	PROPN
biomedich-578	14	72	3β	3β	NUM
biomedich-578	14	73	;	;	PUNCT
biomedich-578	14	74	mapt	mapt	NOUN
biomedich-578	14	75	:	:	PUNCT
biomedich-578	14	76	microtubule	microtubule	NOUN
biomedich-578	14	77	-	-	PUNCT
biomedich-578	14	78	associated	associate	VERB
biomedich-578	14	79	protein	protein	NOUN
biomedich-578	14	80	tau	tau	NOUN
biomedich-578	14	81	;	;	PUNCT
biomedich-578	14	82	mnps	mnps	PROPN
biomedich-578	14	83	:	:	PUNCT
biomedich-578	14	84	marine	marine	ADJ
biomedich-578	14	85	natural	natural	ADJ
biomedich-578	14	86	products	product	NOUN
biomedich-578	14	87	;	;	PUNCT
biomedich-578	14	88	nmda	nmda	ADJ
biomedich-578	14	89	:	:	PUNCT
biomedich-578	14	90	n	n	CCONJ
biomedich-578	14	91	-	-	PUNCT
biomedich-578	14	92	methyl	methyl	NOUN
biomedich-578	14	93	-	-	PUNCT
biomedich-578	14	94	d	d	NOUN
biomedich-578	14	95	-	-	NOUN
biomedich-578	14	96	aspartate	aspartate	NOUN
biomedich-578	14	97	;	;	PUNCT
biomedich-578	14	98	nfts	nft	NOUN
biomedich-578	14	99	:	:	PUNCT
biomedich-578	14	100	intracellular	intracellular	ADJ
biomedich-578	14	101	tau	tau	PROPN
biomedich-578	14	102	neurofibrillary	neurofibrillary	ADJ
biomedich-578	14	103	tangles	tangle	NOUN
biomedich-578	14	104	;	;	PUNCT
biomedich-578	14	105	nachrs	nachrs	ADJ
biomedich-578	14	106	:	:	PUNCT
biomedich-578	14	107	nicotinic	nicotinic	ADJ
biomedich-578	14	108	acetylcholine	acetylcholine	NOUN
biomedich-578	14	109	receptors	receptor	NOUN
biomedich-578	14	110	;	;	PUNCT
biomedich-578	14	111	pkc	pkc	NOUN
biomedich-578	14	112	:	:	PUNCT
biomedich-578	14	113	protein	protein	NOUN
biomedich-578	14	114	kinase	kinase	PROPN
biomedich-578	14	115	c	c	X
biomedich-578	14	116	;	;	PUNCT
biomedich-578	14	117	psen	psen	NOUN
biomedich-578	14	118	:	:	PUNCT
biomedich-578	15	1	presenilin	presenilin	PROPN
biomedich-578	15	2	.	.	PUNCT
biomedich-578	16	1	introduction	introduction	NOUN
biomedich-578	16	2	ad	ad	NOUN
biomedich-578	16	3	is	be	AUX
biomedich-578	16	4	the	the	DET
biomedich-578	16	5	most	most	ADV
biomedich-578	16	6	common	common	ADJ
biomedich-578	16	7	type	type	NOUN
biomedich-578	16	8	of	of	ADP
biomedich-578	16	9	dementia	dementia	NOUN
biomedich-578	16	10	experienced	experience	VERB
biomedich-578	16	11	by	by	ADP
biomedich-578	16	12	individuals	individual	NOUN
biomedich-578	16	13	over	over	ADP
biomedich-578	16	14	the	the	DET
biomedich-578	16	15	age	age	NOUN
biomedich-578	16	16	of	of	ADP
biomedich-578	16	17	65	65	NUM
biomedich-578	16	18	(	(	PUNCT
biomedich-578	16	19	nugraha	nugraha	NOUN
biomedich-578	16	20	et	et	PROPN
biomedich-578	16	21	al	al	PROPN
biomedich-578	16	22	.	.	PROPN
biomedich-578	16	23	,	,	PUNCT
biomedich-578	16	24	2023	2023	NUM
biomedich-578	16	25	)	)	PUNCT
biomedich-578	16	26	.	.	PUNCT
biomedich-578	17	1	dementia	dementia	NOUN
biomedich-578	17	2	is	be	AUX
biomedich-578	17	3	a	a	DET
biomedich-578	17	4	disease	disease	NOUN
biomedich-578	17	5	characterized	characterize	VERB
biomedich-578	17	6	by	by	ADP
biomedich-578	17	7	a	a	DET
biomedich-578	17	8	group	group	NOUN
biomedich-578	17	9	of	of	ADP
biomedich-578	17	10	symptoms	symptom	NOUN
biomedich-578	17	11	consisting	consist	VERB
biomedich-578	17	12	of	of	ADP
biomedich-578	17	13	memory	memory	NOUN
biomedich-578	17	14	impairment	impairment	NOUN
biomedich-578	17	15	,	,	PUNCT
biomedich-578	17	16	behavioural	behavioural	ADJ
biomedich-578	17	17	disturbances	disturbance	NOUN
biomedich-578	17	18	,	,	PUNCT
biomedich-578	17	19	impaired	impaired	ADJ
biomedich-578	17	20	thinking	thinking	NOUN
biomedich-578	17	21	,	,	PUNCT
biomedich-578	17	22	and	and	CCONJ
biomedich-578	17	23	social	social	ADJ
biomedich-578	17	24	abilities	ability	NOUN
biomedich-578	17	25	(	(	PUNCT
biomedich-578	17	26	lyu	lyu	NOUN
biomedich-578	17	27	et	et	PROPN
biomedich-578	17	28	al	al	PROPN
biomedich-578	17	29	.	.	PROPN
biomedich-578	17	30	,	,	PUNCT
biomedich-578	17	31	2021	2021	NUM
biomedich-578	17	32	)	)	PUNCT
biomedich-578	17	33	.	.	PUNCT
biomedich-578	18	1	in	in	ADP
biomedich-578	18	2	severe	severe	ADJ
biomedich-578	18	3	stages	stage	NOUN
biomedich-578	18	4	,	,	PUNCT
biomedich-578	18	5	individuals	individual	NOUN
biomedich-578	18	6	with	with	ADP
biomedich-578	18	7	this	this	DET
biomedich-578	18	8	disease	disease	NOUN
biomedich-578	18	9	will	will	AUX
biomedich-578	18	10	experience	experience	VERB
biomedich-578	18	11	a	a	DET
biomedich-578	18	12	reduced	reduced	ADJ
biomedich-578	18	13	quality	quality	NOUN
biomedich-578	18	14	of	of	ADP
biomedich-578	18	15	life	life	NOUN
biomedich-578	18	16	and	and	CCONJ
biomedich-578	18	17	may	may	AUX
biomedich-578	18	18	become	become	VERB
biomedich-578	18	19	unable	unable	ADJ
biomedich-578	18	20	to	to	PART
biomedich-578	18	21	carry	carry	VERB
biomedich-578	18	22	out	out	ADP
biomedich-578	18	23	activities	activity	NOUN
biomedich-578	18	24	independently	independently	ADV
biomedich-578	18	25	(	(	PUNCT
biomedich-578	18	26	nugraha	nugraha	NOUN
biomedich-578	18	27	et	et	PROPN
biomedich-578	18	28	al	al	PROPN
biomedich-578	18	29	.	.	PROPN
biomedich-578	18	30	,	,	PUNCT
biomedich-578	18	31	2023	2023	NUM
biomedich-578	18	32	)	)	PUNCT
biomedich-578	18	33	.	.	PUNCT
biomedich-578	19	1	the	the	DET
biomedich-578	19	2	number	number	NOUN
biomedich-578	19	3	of	of	ADP
biomedich-578	19	4	individuals	individual	NOUN
biomedich-578	19	5	with	with	ADP
biomedich-578	19	6	dementia	dementia	NOUN
biomedich-578	19	7	worldwide	worldwide	ADV
biomedich-578	19	8	is	be	AUX
biomedich-578	19	9	estimated	estimate	VERB
biomedich-578	19	10	to	to	PART
biomedich-578	19	11	continue	continue	VERB
biomedich-578	19	12	increasing	increase	VERB
biomedich-578	19	13	alongside	alongside	ADP
biomedich-578	19	14	the	the	DET
biomedich-578	19	15	ageing	age	VERB
biomedich-578	19	16	population	population	NOUN
biomedich-578	19	17	.	.	PUNCT
biomedich-578	20	1	in	in	ADP
biomedich-578	20	2	2019	2019	NUM
biomedich-578	20	3	,	,	PUNCT
biomedich-578	20	4	55	55	NUM
biomedich-578	20	5	million	million	NUM
biomedich-578	20	6	people	people	NOUN
biomedich-578	20	7	were	be	AUX
biomedich-578	20	8	suffering	suffer	VERB
biomedich-578	20	9	from	from	ADP
biomedich-578	20	10	dementia	dementia	NOUN
biomedich-578	20	11	,	,	PUNCT
biomedich-578	20	12	this	this	DET
biomedich-578	20	13	number	number	NOUN
biomedich-578	20	14	is	be	AUX
biomedich-578	20	15	expected	expect	VERB
biomedich-578	20	16	to	to	PART
biomedich-578	20	17	rise	rise	VERB
biomedich-578	20	18	to	to	ADP
biomedich-578	20	19	139	139	NUM
biomedich-578	20	20	million	million	NUM
biomedich-578	20	21	by	by	ADP
biomedich-578	20	22	2050	2050	NUM
biomedich-578	20	23	(	(	PUNCT
biomedich-578	20	24	rivarti	rivarti	PROPN
biomedich-578	20	25	et	et	PROPN
biomedich-578	20	26	al	al	PROPN
biomedich-578	20	27	.	.	PROPN
biomedich-578	20	28	,	,	PUNCT
biomedich-578	20	29	2023	2023	NUM
biomedich-578	20	30	)	)	PUNCT
biomedich-578	20	31	.	.	PUNCT
biomedich-578	21	1	the	the	DET
biomedich-578	21	2	costs	cost	NOUN
biomedich-578	21	3	incurred	incur	VERB
biomedich-578	21	4	for	for	ADP
biomedich-578	21	5	dementia	dementia	NOUN
biomedich-578	21	6	care	care	NOUN
biomedich-578	21	7	amounted	amount	VERB
biomedich-578	21	8	to	to	ADP
biomedich-578	21	9	approximately	approximately	ADV
biomedich-578	21	10	818	818	NUM
biomedich-578	21	11	billion	billion	NUM
biomedich-578	21	12	dollars	dollar	NOUN
biomedich-578	21	13	in	in	ADP
biomedich-578	21	14	2015	2015	NUM
biomedich-578	21	15	and	and	CCONJ
biomedich-578	21	16	are	be	AUX
biomedich-578	21	17	projected	project	VERB
biomedich-578	21	18	to	to	PART
biomedich-578	21	19	continue	continue	VERB
biomedich-578	21	20	increasing	increase	VERB
biomedich-578	21	21	by	by	ADP
biomedich-578	21	22	35	35	NUM
biomedich-578	21	23	%	%	NOUN
biomedich-578	21	24	every	every	DET
biomedich-578	21	25	five	five	NUM
biomedich-578	21	26	years	year	NOUN
biomedich-578	21	27	.	.	PUNCT
biomedich-578	22	1	the	the	DET
biomedich-578	22	2	social	social	ADJ
biomedich-578	22	3	impact	impact	NOUN
biomedich-578	22	4	is	be	AUX
biomedich-578	22	5	also	also	ADV
biomedich-578	22	6	experienced	experience	VERB
biomedich-578	22	7	by	by	ADP
biomedich-578	22	8	individuals	individual	NOUN
biomedich-578	22	9	with	with	ADP
biomedich-578	22	10	the	the	DET
biomedich-578	22	11	disease	disease	NOUN
biomedich-578	22	12	and	and	CCONJ
biomedich-578	22	13	their	their	PRON
biomedich-578	22	14	families	family	NOUN
biomedich-578	22	15	who	who	PRON
biomedich-578	22	16	care	care	VERB
biomedich-578	22	17	for	for	ADP
biomedich-578	22	18	them	they	PRON
biomedich-578	22	19	(	(	PUNCT
biomedich-578	22	20	bălașa	bălașa	NOUN
biomedich-578	22	21	et	et	PROPN
biomedich-578	22	22	al	al	PROPN
biomedich-578	22	23	.	.	PROPN
biomedich-578	22	24	,	,	PUNCT
biomedich-578	22	25	2020	2020	NUM
biomedich-578	22	26	)	)	PUNCT
biomedich-578	22	27	.	.	PUNCT
biomedich-578	23	1	thus	thus	ADV
biomedich-578	23	2	,	,	PUNCT
biomedich-578	23	3	ad	ad	NOUN
biomedich-578	23	4	has	have	AUX
biomedich-578	23	5	become	become	VERB
biomedich-578	23	6	a	a	DET
biomedich-578	23	7	severe	severe	ADJ
biomedich-578	23	8	public	public	ADJ
biomedich-578	23	9	health	health	NOUN
biomedich-578	23	10	issue	issue	NOUN
biomedich-578	23	11	with	with	ADP
biomedich-578	23	12	high	high	ADJ
biomedich-578	23	13	medical	medical	ADJ
biomedich-578	23	14	costs	cost	NOUN
biomedich-578	23	15	and	and	CCONJ
biomedich-578	23	16	reported	report	VERB
biomedich-578	23	17	no	no	DET
biomedich-578	23	18	cure	cure	NOUN
biomedich-578	23	19	(	(	PUNCT
biomedich-578	23	20	hu	hu	PROPN
biomedich-578	23	21	et	et	PROPN
biomedich-578	23	22	al	al	PROPN
biomedich-578	23	23	.	.	PROPN
biomedich-578	23	24	,	,	PUNCT
biomedich-578	23	25	2023	2023	NUM
biomedich-578	23	26	)	)	PUNCT
biomedich-578	23	27	.	.	PUNCT
biomedich-578	24	1	ad	ad	NOUN
biomedich-578	24	2	therapies	therapy	NOUN
biomedich-578	24	3	that	that	PRON
biomedich-578	24	4	have	have	AUX
biomedich-578	24	5	been	be	AUX
biomedich-578	24	6	used	use	VERB
biomedich-578	24	7	and	and	CCONJ
biomedich-578	24	8	approved	approve	VERB
biomedich-578	24	9	by	by	ADP
biomedich-578	24	10	the	the	DET
biomedich-578	24	11	u.s	u.s	PROPN
biomedich-578	24	12	.	.	PROPN
biomedich-578	24	13	food	food	PROPN
biomedich-578	24	14	and	and	CCONJ
biomedich-578	24	15	drug	drug	PROPN
biomedich-578	24	16	administration	administration	PROPN
biomedich-578	24	17	(	(	PUNCT
biomedich-578	24	18	fda	fda	PROPN
biomedich-578	24	19	)	)	PUNCT
biomedich-578	24	20	are	be	AUX
biomedich-578	24	21	acetylcholinesterase	acetylcholinesterase	NOUN
biomedich-578	24	22	inhibitors	inhibitor	NOUN
biomedich-578	24	23	(	(	PUNCT
biomedich-578	24	24	acheis	acheis	NOUN
biomedich-578	24	25	)	)	PUNCT
biomedich-578	24	26	(	(	PUNCT
biomedich-578	24	27	such	such	ADJ
biomedich-578	24	28	as	as	ADP
biomedich-578	24	29	donepezil	donepezil	NOUN
biomedich-578	24	30	,	,	PUNCT
biomedich-578	24	31	rivastigmine	rivastigmine	NOUN
biomedich-578	24	32	,	,	PUNCT
biomedich-578	24	33	and	and	CCONJ
biomedich-578	24	34	galantamine	galantamine	NOUN
biomedich-578	24	35	)	)	PUNCT
biomedich-578	24	36	and	and	CCONJ
biomedich-578	24	37	n	n	CCONJ
biomedich-578	24	38	-	-	PUNCT
biomedich-578	24	39	methyld	methyld	NOUN
biomedich-578	24	40	-	-	PUNCT
biomedich-578	24	41	aspartate	aspartate	NOUN
biomedich-578	24	42	(	(	PUNCT
biomedich-578	24	43	nmda	nmda	ADJ
biomedich-578	24	44	)	)	PUNCT
biomedich-578	24	45	receptor	receptor	NOUN
biomedich-578	24	46	antagonist	antagonist	NOUN
biomedich-578	24	47	(	(	PUNCT
biomedich-578	24	48	memantine	memantine	NOUN
biomedich-578	24	49	)	)	PUNCT
biomedich-578	24	50	,	,	PUNCT
biomedich-578	24	51	which	which	PRON
biomedich-578	24	52	only	only	ADV
biomedich-578	24	53	aim	aim	VERB
biomedich-578	24	54	to	to	PART
biomedich-578	24	55	improve	improve	VERB
biomedich-578	24	56	ad	ad	NOUN
biomedich-578	24	57	symptoms	symptom	NOUN
biomedich-578	24	58	(	(	PUNCT
biomedich-578	24	59	li	li	PROPN
biomedich-578	24	60	et	et	PROPN
biomedich-578	24	61	al	al	PROPN
biomedich-578	24	62	.	.	PROPN
biomedich-578	24	63	,	,	PUNCT
biomedich-578	24	64	2019	2019	NUM
biomedich-578	24	65	;	;	PUNCT
biomedich-578	24	66	cummings	cummings	PROPN
biomedich-578	24	67	et	et	PROPN
biomedich-578	24	68	al	al	PROPN
biomedich-578	24	69	.	.	PROPN
biomedich-578	24	70	,	,	PUNCT
biomedich-578	24	71	2019	2019	NUM
biomedich-578	24	72	;	;	PUNCT
biomedich-578	24	73	kim	kim	PROPN
biomedich-578	24	74	et	et	PROPN
biomedich-578	24	75	al	al	PROPN
biomedich-578	24	76	.	.	PROPN
biomedich-578	24	77	,	,	PUNCT
biomedich-578	24	78	2022	2022	NUM
biomedich-578	24	79	)	)	PUNCT
biomedich-578	24	80	.	.	PUNCT
biomedich-578	25	1	afterwards	afterwards	ADV
biomedich-578	25	2	,	,	PUNCT
biomedich-578	25	3	there	there	PRON
biomedich-578	25	4	has	have	AUX
biomedich-578	25	5	not	not	PART
biomedich-578	25	6	been	be	AUX
biomedich-578	25	7	any	any	DET
biomedich-578	25	8	therapy	therapy	NOUN
biomedich-578	25	9	approved	approve	VERB
biomedich-578	25	10	by	by	ADP
biomedich-578	25	11	the	the	DET
biomedich-578	25	12	fda	fda	PROPN
biomedich-578	25	13	over	over	ADP
biomedich-578	25	14	the	the	DET
biomedich-578	25	15	past	past	ADJ
biomedich-578	25	16	two	two	NUM
biomedich-578	25	17	decades	decade	NOUN
biomedich-578	25	18	(	(	PUNCT
biomedich-578	25	19	kim	kim	PROPN
biomedich-578	25	20	et	et	PROPN
biomedich-578	25	21	al	al	PROPN
biomedich-578	25	22	.	.	PROPN
biomedich-578	25	23	,	,	PUNCT
biomedich-578	25	24	2022	2022	NUM
biomedich-578	25	25	)	)	PUNCT
biomedich-578	25	26	.	.	PUNCT
biomedich-578	26	1	the	the	DET
biomedich-578	26	2	discovery	discovery	NOUN
biomedich-578	26	3	of	of	ADP
biomedich-578	26	4	disease	disease	NOUN
biomedich-578	26	5	-	-	PUNCT
biomedich-578	26	6	modifying	modify	VERB
biomedich-578	26	7	treatments	treatment	NOUN
biomedich-578	26	8	(	(	PUNCT
biomedich-578	26	9	dmts	dmts	PROPN
biomedich-578	26	10	)	)	PUNCT
biomedich-578	26	11	,	,	PUNCT
biomedich-578	26	12	a	a	DET
biomedich-578	26	13	therapeutic	therapeutic	ADJ
biomedich-578	26	14	strategy	strategy	NOUN
biomedich-578	26	15	that	that	PRON
biomedich-578	26	16	changes	change	VERB
biomedich-578	26	17	the	the	DET
biomedich-578	26	18	disease	disease	NOUN
biomedich-578	26	19	course	course	NOUN
biomedich-578	26	20	by	by	ADP
biomedich-578	26	21	addressing	address	VERB
biomedich-578	26	22	the	the	DET
biomedich-578	26	23	underlying	underlying	ADJ
biomedich-578	26	24	biological	biological	ADJ
biomedich-578	26	25	pathway	pathway	NOUN
biomedich-578	26	26	,	,	PUNCT
biomedich-578	26	27	faces	face	VERB
biomedich-578	26	28	many	many	ADJ
biomedich-578	26	29	challenges	challenge	NOUN
biomedich-578	26	30	.	.	PUNCT
biomedich-578	27	1	dmts	dmts	NOUN
biomedich-578	27	2	inhibiting	inhibit	VERB
biomedich-578	27	3	the	the	DET
biomedich-578	27	4	production	production	NOUN
biomedich-578	27	5	and	and	CCONJ
biomedich-578	27	6	aggregation	aggregation	NOUN
biomedich-578	27	7	of	of	ADP
biomedich-578	27	8	amyloid	amyloid	NOUN
biomedich-578	27	9	β	β	X
biomedich-578	27	10	(	(	PUNCT
biomedich-578	27	11	aβ	aβ	NOUN
biomedich-578	27	12	)	)	PUNCT
biomedich-578	27	13	have	have	AUX
biomedich-578	27	14	seen	see	VERB
biomedich-578	27	15	many	many	ADJ
biomedich-578	27	16	failures	failure	NOUN
biomedich-578	27	17	during	during	ADP
biomedich-578	27	18	clinical	clinical	ADJ
biomedich-578	27	19	trials	trial	NOUN
biomedich-578	27	20	.	.	PUNCT
biomedich-578	28	1	clinical	clinical	ADJ
biomedich-578	28	2	trial	trial	NOUN
biomedich-578	28	3	phases	phase	NOUN
biomedich-578	28	4	for	for	ADP
biomedich-578	28	5	verubecestat	verubecestat	NOUN
biomedich-578	28	6	,	,	PUNCT
biomedich-578	28	7	crenezumab	crenezumab	NOUN
biomedich-578	28	8	,	,	PUNCT
biomedich-578	28	9	lanabecestat	lanabecestat	NOUN
biomedich-578	28	10	,	,	PUNCT
biomedich-578	28	11	and	and	CCONJ
biomedich-578	28	12	solanezumab	solanezumab	NOUN
biomedich-578	28	13	failed	fail	VERB
biomedich-578	28	14	and	and	CCONJ
biomedich-578	28	15	were	be	AUX
biomedich-578	28	16	discontinued	discontinue	VERB
biomedich-578	28	17	due	due	ADP
biomedich-578	28	18	to	to	ADP
biomedich-578	28	19	ineffectiveness	ineffectiveness	NOUN
biomedich-578	28	20	and	and	CCONJ
biomedich-578	28	21	negative	negative	ADJ
biomedich-578	28	22	risk	risk	NOUN
biomedich-578	28	23	/	/	SYM
biomedich-578	28	24	benefit	benefit	NOUN
biomedich-578	28	25	ratio	ratio	NOUN
biomedich-578	28	26	https://doi.org/10.14421/biomedich.2024.132.433-441	https://doi.org/10.14421/biomedich.2024.132.433-441	CCONJ
biomedich-578	28	27	434	434	NUM
biomedich-578	28	28	biology	biology	NOUN
biomedich-578	28	29	,	,	PUNCT
biomedich-578	28	30	medicine	medicine	NOUN
biomedich-578	28	31	,	,	PUNCT
biomedich-578	28	32	&	&	CCONJ
biomedich-578	28	33	natural	natural	ADJ
biomedich-578	28	34	product	product	NOUN
biomedich-578	28	35	chemistry	chemistry	NOUN
biomedich-578	28	36	13	13	NUM
biomedich-578	28	37	(	(	PUNCT
biomedich-578	28	38	2	2	NUM
biomedich-578	28	39	)	)	PUNCT
biomedich-578	28	40	,	,	PUNCT
biomedich-578	28	41	2024	2024	NUM
biomedich-578	28	42	:	:	PUNCT
biomedich-578	28	43	433	433	NUM
biomedich-578	28	44	-	-	SYM
biomedich-578	28	45	441	441	NUM
biomedich-578	28	46	(	(	PUNCT
biomedich-578	28	47	cummings	cummings	PROPN
biomedich-578	28	48	et	et	PROPN
biomedich-578	28	49	al	al	PROPN
biomedich-578	28	50	.	.	PROPN
biomedich-578	28	51	,	,	PUNCT
biomedich-578	28	52	2019	2019	NUM
biomedich-578	28	53	;	;	PUNCT
biomedich-578	28	54	dog	dog	NOUN
biomedich-578	28	55	et	et	PROPN
biomedich-578	28	56	al	al	PROPN
biomedich-578	28	57	.	.	PROPN
biomedich-578	28	58	,	,	PUNCT
biomedich-578	28	59	2019	2019	NUM
biomedich-578	28	60	)	)	PUNCT
biomedich-578	28	61	.	.	PUNCT
biomedich-578	29	1	the	the	DET
biomedich-578	29	2	failure	failure	NOUN
biomedich-578	29	3	to	to	PART
biomedich-578	29	4	find	find	VERB
biomedich-578	29	5	effective	effective	ADJ
biomedich-578	29	6	dmts	dmts	NOUN
biomedich-578	29	7	for	for	ADP
biomedich-578	29	8	ad	ad	NOUN
biomedich-578	29	9	is	be	AUX
biomedich-578	29	10	caused	cause	VERB
biomedich-578	29	11	by	by	ADP
biomedich-578	29	12	the	the	DET
biomedich-578	29	13	wrong	wrong	ADJ
biomedich-578	29	14	main	main	ADJ
biomedich-578	29	15	target	target	NOUN
biomedich-578	29	16	of	of	ADP
biomedich-578	29	17	treatment	treatment	NOUN
biomedich-578	29	18	,	,	PUNCT
biomedich-578	29	19	loss	loss	NOUN
biomedich-578	29	20	of	of	ADP
biomedich-578	29	21	follow	follow	NOUN
biomedich-578	29	22	-	-	PUNCT
biomedich-578	29	23	up	up	NOUN
biomedich-578	29	24	during	during	ADP
biomedich-578	29	25	long	long	ADJ
biomedich-578	29	26	-	-	PUNCT
biomedich-578	29	27	term	term	NOUN
biomedich-578	29	28	clinical	clinical	ADJ
biomedich-578	29	29	trials	trial	NOUN
biomedich-578	29	30	,	,	PUNCT
biomedich-578	29	31	inappropriate	inappropriate	ADJ
biomedich-578	29	32	drug	drug	NOUN
biomedich-578	29	33	doses	dose	NOUN
biomedich-578	29	34	,	,	PUNCT
biomedich-578	29	35	and	and	CCONJ
biomedich-578	29	36	too	too	ADV
biomedich-578	29	37	-	-	PUNCT
biomedich-578	29	38	late	late	ADJ
biomedich-578	29	39	starting	starting	NOUN
biomedich-578	29	40	of	of	ADP
biomedich-578	29	41	therapies	therapy	NOUN
biomedich-578	29	42	in	in	ADP
biomedich-578	29	43	disease	disease	NOUN
biomedich-578	29	44	development	development	NOUN
biomedich-578	29	45	(	(	PUNCT
biomedich-578	29	46	mehta	mehta	PROPN
biomedich-578	29	47	et	et	PROPN
biomedich-578	29	48	al	al	PROPN
biomedich-578	29	49	.	.	PROPN
biomedich-578	29	50	,	,	PUNCT
biomedich-578	29	51	2017	2017	NUM
biomedich-578	29	52	;	;	PUNCT
biomedich-578	29	53	kim	kim	PROPN
biomedich-578	29	54	et	et	PROPN
biomedich-578	29	55	al	al	PROPN
biomedich-578	29	56	.	.	PROPN
biomedich-578	29	57	,	,	PUNCT
biomedich-578	29	58	2022	2022	NUM
biomedich-578	29	59	)	)	PUNCT
biomedich-578	29	60	.	.	PUNCT
biomedich-578	30	1	the	the	DET
biomedich-578	30	2	main	main	ADJ
biomedich-578	30	3	objections	objection	NOUN
biomedich-578	30	4	currently	currently	ADV
biomedich-578	30	5	faced	face	VERB
biomedich-578	30	6	in	in	ADP
biomedich-578	30	7	ad	ad	NOUN
biomedich-578	30	8	treatment	treatment	NOUN
biomedich-578	30	9	are	be	AUX
biomedich-578	30	10	a	a	DET
biomedich-578	30	11	profound	profound	ADJ
biomedich-578	30	12	understanding	understanding	NOUN
biomedich-578	30	13	of	of	ADP
biomedich-578	30	14	the	the	DET
biomedich-578	30	15	disease	disease	NOUN
biomedich-578	30	16	and	and	CCONJ
biomedich-578	30	17	its	its	PRON
biomedich-578	30	18	pathological	pathological	ADJ
biomedich-578	30	19	mechanisms	mechanism	NOUN
biomedich-578	30	20	,	,	PUNCT
biomedich-578	30	21	reliable	reliable	ADJ
biomedich-578	30	22	biomarkers	biomarker	NOUN
biomedich-578	30	23	to	to	PART
biomedich-578	30	24	enable	enable	VERB
biomedich-578	30	25	early	early	ADJ
biomedich-578	30	26	diagnosis	diagnosis	NOUN
biomedich-578	30	27	,	,	PUNCT
biomedich-578	30	28	identification	identification	NOUN
biomedich-578	30	29	and	and	CCONJ
biomedich-578	30	30	development	development	NOUN
biomedich-578	30	31	of	of	ADP
biomedich-578	30	32	new	new	ADJ
biomedich-578	30	33	drugs	drug	NOUN
biomedich-578	30	34	and	and	CCONJ
biomedich-578	30	35	therapeutic	therapeutic	ADJ
biomedich-578	30	36	strategies	strategy	NOUN
biomedich-578	30	37	that	that	PRON
biomedich-578	30	38	slow	slow	ADJ
biomedich-578	30	39	disease	disease	NOUN
biomedich-578	30	40	progression	progression	NOUN
biomedich-578	30	41	,	,	PUNCT
biomedich-578	30	42	and	and	CCONJ
biomedich-578	30	43	the	the	DET
biomedich-578	30	44	development	development	NOUN
biomedich-578	30	45	of	of	ADP
biomedich-578	30	46	prevention	prevention	NOUN
biomedich-578	30	47	protocols	protocol	NOUN
biomedich-578	30	48	that	that	PRON
biomedich-578	30	49	can	can	AUX
biomedich-578	30	50	be	be	AUX
biomedich-578	30	51	used	use	VERB
biomedich-578	30	52	at	at	ADP
biomedich-578	30	53	high	high	ADJ
biomedich-578	30	54	-	-	PUNCT
biomedich-578	30	55	risk	risk	NOUN
biomedich-578	30	56	populations	population	NOUN
biomedich-578	30	57	(	(	PUNCT
biomedich-578	30	58	cacabelos	cacabelo	NOUN
biomedich-578	30	59	,	,	PUNCT
biomedich-578	30	60	2022	2022	NUM
biomedich-578	30	61	)	)	PUNCT
biomedich-578	30	62	.	.	PUNCT
biomedich-578	31	1	since	since	SCONJ
biomedich-578	31	2	ad	ad	NOUN
biomedich-578	31	3	is	be	AUX
biomedich-578	31	4	caused	cause	VERB
biomedich-578	31	5	by	by	ADP
biomedich-578	31	6	various	various	ADJ
biomedich-578	31	7	molecular	molecular	ADJ
biomedich-578	31	8	processes	process	NOUN
biomedich-578	31	9	,	,	PUNCT
biomedich-578	31	10	identifying	identify	VERB
biomedich-578	31	11	a	a	DET
biomedich-578	31	12	drug	drug	NOUN
biomedich-578	31	13	capable	capable	ADJ
biomedich-578	31	14	of	of	ADP
biomedich-578	31	15	modulating	modulate	VERB
biomedich-578	31	16	more	more	ADJ
biomedich-578	31	17	than	than	ADP
biomedich-578	31	18	one	one	NUM
biomedich-578	31	19	target	target	NOUN
biomedich-578	31	20	is	be	AUX
biomedich-578	31	21	one	one	NUM
biomedich-578	31	22	of	of	ADP
biomedich-578	31	23	the	the	DET
biomedich-578	31	24	best	good	ADJ
biomedich-578	31	25	strategies	strategy	NOUN
biomedich-578	31	26	in	in	ADP
biomedich-578	31	27	drug	drug	NOUN
biomedich-578	31	28	discovery	discovery	NOUN
biomedich-578	31	29	and	and	CCONJ
biomedich-578	31	30	development	development	NOUN
biomedich-578	31	31	(	(	PUNCT
biomedich-578	31	32	martins	martin	NOUN
biomedich-578	31	33	et	et	NOUN
biomedich-578	31	34	al	al	PROPN
biomedich-578	31	35	.	.	PROPN
biomedich-578	31	36	,	,	PUNCT
biomedich-578	31	37	2020	2020	NUM
biomedich-578	31	38	)	)	PUNCT
biomedich-578	31	39	.	.	PUNCT
biomedich-578	32	1	to	to	ADP
biomedich-578	32	2	date	date	NOUN
biomedich-578	32	3	,	,	PUNCT
biomedich-578	32	4	marine	marine	ADJ
biomedich-578	32	5	natural	natural	ADJ
biomedich-578	32	6	products	product	NOUN
biomedich-578	32	7	(	(	PUNCT
biomedich-578	32	8	mnps	mnps	PROPN
biomedich-578	32	9	)	)	PUNCT
biomedich-578	32	10	have	have	AUX
biomedich-578	32	11	been	be	AUX
biomedich-578	32	12	demonstrated	demonstrate	VERB
biomedich-578	32	13	to	to	PART
biomedich-578	32	14	be	be	AUX
biomedich-578	32	15	the	the	DET
biomedich-578	32	16	most	most	ADV
biomedich-578	32	17	promising	promising	ADJ
biomedich-578	32	18	candidates	candidate	NOUN
biomedich-578	32	19	for	for	ADP
biomedich-578	32	20	therapy	therapy	NOUN
biomedich-578	32	21	of	of	ADP
biomedich-578	32	22	various	various	ADJ
biomedich-578	32	23	diseases	disease	NOUN
biomedich-578	32	24	and	and	CCONJ
biomedich-578	32	25	are	be	AUX
biomedich-578	32	26	known	know	VERB
biomedich-578	32	27	to	to	PART
biomedich-578	32	28	have	have	VERB
biomedich-578	32	29	more	more	ADV
biomedich-578	32	30	excellent	excellent	ADJ
biomedich-578	32	31	biological	biological	ADJ
biomedich-578	32	32	activity	activity	NOUN
biomedich-578	32	33	than	than	ADP
biomedich-578	32	34	terrestrial	terrestrial	ADJ
biomedich-578	32	35	natural	natural	ADJ
biomedich-578	32	36	sources	source	NOUN
biomedich-578	32	37	(	(	PUNCT
biomedich-578	32	38	bălașa	bălașa	NOUN
biomedich-578	32	39	et	et	PROPN
biomedich-578	32	40	al	al	PROPN
biomedich-578	32	41	.	.	PROPN
biomedich-578	32	42	,	,	PUNCT
biomedich-578	32	43	2020	2020	NUM
biomedich-578	32	44	)	)	PUNCT
biomedich-578	32	45	.	.	PUNCT
biomedich-578	33	1	therefore	therefore	ADV
biomedich-578	33	2	,	,	PUNCT
biomedich-578	33	3	this	this	DET
biomedich-578	33	4	article	article	NOUN
biomedich-578	33	5	aims	aim	VERB
biomedich-578	33	6	to	to	PART
biomedich-578	33	7	review	review	VERB
biomedich-578	33	8	the	the	DET
biomedich-578	33	9	prime	prime	ADJ
biomedich-578	33	10	targets	target	NOUN
biomedich-578	33	11	for	for	ADP
biomedich-578	33	12	dmts	dmts	NOUN
biomedich-578	33	13	of	of	ADP
biomedich-578	33	14	ad	ad	NOUN
biomedich-578	33	15	and	and	CCONJ
biomedich-578	33	16	mnps	mnps	NOUN
biomedich-578	33	17	prospecting	prospecting	NOUN
biomedich-578	33	18	for	for	ADP
biomedich-578	33	19	ad	ad	NOUN
biomedich-578	33	20	treatment	treatment	NOUN
biomedich-578	33	21	focusing	focus	VERB
biomedich-578	33	22	on	on	ADP
biomedich-578	33	23	these	these	DET
biomedich-578	33	24	targets	target	NOUN
biomedich-578	33	25	.	.	PUNCT
biomedich-578	34	1	prime	prime	ADJ
biomedich-578	34	2	targets	target	NOUN
biomedich-578	34	3	for	for	ADP
biomedich-578	34	4	disease	disease	NOUN
biomedich-578	34	5	-	-	PUNCT
biomedich-578	34	6	modifying	modify	VERB
biomedich-578	34	7	treatments	treatment	NOUN
biomedich-578	34	8	(	(	PUNCT
biomedich-578	34	9	dmts	dmts	NOUN
biomedich-578	34	10	)	)	PUNCT
biomedich-578	34	11	in	in	ADP
biomedich-578	34	12	ad	ad	NOUN
biomedich-578	34	13	the	the	DET
biomedich-578	34	14	failure	failure	NOUN
biomedich-578	34	15	to	to	PART
biomedich-578	34	16	find	find	VERB
biomedich-578	34	17	an	an	DET
biomedich-578	34	18	effective	effective	ADJ
biomedich-578	34	19	therapy	therapy	NOUN
biomedich-578	34	20	for	for	ADP
biomedich-578	34	21	ad	ad	NOUN
biomedich-578	34	22	is	be	AUX
biomedich-578	34	23	primarily	primarily	ADV
biomedich-578	34	24	due	due	ADJ
biomedich-578	34	25	to	to	ADP
biomedich-578	34	26	a	a	DET
biomedich-578	34	27	lack	lack	NOUN
biomedich-578	34	28	of	of	ADP
biomedich-578	34	29	drug	drug	NOUN
biomedich-578	34	30	discoveries	discovery	NOUN
biomedich-578	34	31	focusing	focus	VERB
biomedich-578	34	32	on	on	ADP
biomedich-578	34	33	multiple	multiple	ADJ
biomedich-578	34	34	targets	target	NOUN
biomedich-578	34	35	associated	associate	VERB
biomedich-578	34	36	with	with	ADP
biomedich-578	34	37	the	the	DET
biomedich-578	34	38	complex	complex	ADJ
biomedich-578	34	39	pathophysiology	pathophysiology	NOUN
biomedich-578	34	40	of	of	ADP
biomedich-578	34	41	ad	ad	NOUN
biomedich-578	34	42	(	(	PUNCT
biomedich-578	34	43	rivarti	rivarti	PROPN
biomedich-578	34	44	et	et	NOUN
biomedich-578	34	45	al	al	PROPN
biomedich-578	34	46	.	.	PROPN
biomedich-578	34	47	,	,	PUNCT
biomedich-578	34	48	2023	2023	NUM
biomedich-578	34	49	)	)	PUNCT
biomedich-578	34	50	.	.	PUNCT
biomedich-578	35	1	the	the	DET
biomedich-578	35	2	pathogenesis	pathogenesis	NOUN
biomedich-578	35	3	of	of	ADP
biomedich-578	35	4	ad	ad	NOUN
biomedich-578	35	5	is	be	AUX
biomedich-578	35	6	inconclusive	inconclusive	ADJ
biomedich-578	35	7	,	,	PUNCT
biomedich-578	35	8	but	but	CCONJ
biomedich-578	35	9	atypical	atypical	ADJ
biomedich-578	35	10	deposition	deposition	NOUN
biomedich-578	35	11	of	of	ADP
biomedich-578	35	12	amyloid	amyloid	NOUN
biomedich-578	35	13	and	and	CCONJ
biomedich-578	35	14	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	35	15	of	of	ADP
biomedich-578	35	16	tau	tau	PROPN
biomedich-578	35	17	protein	protein	NOUN
biomedich-578	35	18	in	in	ADP
biomedich-578	35	19	the	the	DET
biomedich-578	35	20	brain	brain	NOUN
biomedich-578	35	21	have	have	AUX
biomedich-578	35	22	been	be	AUX
biomedich-578	35	23	key	key	ADJ
biomedich-578	35	24	targets	target	NOUN
biomedich-578	35	25	for	for	ADP
biomedich-578	35	26	drug	drug	NOUN
biomedich-578	35	27	discovery	discovery	NOUN
biomedich-578	35	28	for	for	ADP
biomedich-578	35	29	the	the	DET
biomedich-578	35	30	disease	disease	NOUN
biomedich-578	35	31	(	(	PUNCT
biomedich-578	35	32	hu	hu	PROPN
biomedich-578	35	33	et	et	PROPN
biomedich-578	35	34	al	al	PROPN
biomedich-578	35	35	.	.	PROPN
biomedich-578	35	36	,	,	PUNCT
biomedich-578	35	37	2023	2023	NUM
biomedich-578	35	38	)	)	PUNCT
biomedich-578	35	39	.	.	PUNCT
biomedich-578	36	1	the	the	DET
biomedich-578	36	2	main	main	ADJ
biomedich-578	36	3	targets	target	NOUN
biomedich-578	36	4	for	for	ADP
biomedich-578	36	5	dmts	dmts	NOUN
biomedich-578	36	6	in	in	ADP
biomedich-578	36	7	ad	ad	NOUN
biomedich-578	36	8	are	be	AUX
biomedich-578	36	9	extracellular	extracellular	ADJ
biomedich-578	36	10	amyloid	amyloid	NOUN
biomedich-578	36	11	plaques	plaque	NOUN
biomedich-578	36	12	and	and	CCONJ
biomedich-578	36	13	intracellular	intracellular	ADJ
biomedich-578	36	14	tau	tau	PROPN
biomedich-578	36	15	neurofibrillary	neurofibrillary	ADJ
biomedich-578	36	16	tangles	tangle	NOUN
biomedich-578	36	17	(	(	PUNCT
biomedich-578	36	18	nfts	nft	NOUN
biomedich-578	36	19	)	)	PUNCT
biomedich-578	36	20	,	,	PUNCT
biomedich-578	36	21	where	where	SCONJ
biomedich-578	36	22	β	β	X
biomedich-578	36	23	-	-	ADJ
biomedich-578	36	24	secretase	secretase	ADJ
biomedich-578	36	25	enzyme	enzyme	NOUN
biomedich-578	36	26	(	(	PUNCT
biomedich-578	36	27	bace-1	bace-1	NOUN
biomedich-578	36	28	)	)	PUNCT
biomedich-578	36	29	activation	activation	NOUN
biomedich-578	36	30	,	,	PUNCT
biomedich-578	36	31	neuroinflammation	neuroinflammation	NOUN
biomedich-578	36	32	,	,	PUNCT
biomedich-578	36	33	oxidation	oxidation	NOUN
biomedich-578	36	34	,	,	PUNCT
biomedich-578	36	35	and	and	CCONJ
biomedich-578	36	36	tau	tau	PROPN
biomedich-578	36	37	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	36	38	are	be	AUX
biomedich-578	36	39	elements	element	NOUN
biomedich-578	36	40	involved	involve	VERB
biomedich-578	36	41	in	in	ADP
biomedich-578	36	42	the	the	DET
biomedich-578	36	43	process	process	NOUN
biomedich-578	36	44	(	(	PUNCT
biomedich-578	36	45	figure	figure	NOUN
biomedich-578	36	46	1	1	NUM
biomedich-578	36	47	)	)	PUNCT
biomedich-578	36	48	(	(	PUNCT
biomedich-578	36	49	park	park	NOUN
biomedich-578	36	50	et	et	PROPN
biomedich-578	36	51	al	al	PROPN
biomedich-578	36	52	.	.	PROPN
biomedich-578	36	53	,	,	PUNCT
biomedich-578	36	54	2019	2019	NUM
biomedich-578	36	55	;	;	PUNCT
biomedich-578	36	56	kim	kim	PROPN
biomedich-578	36	57	et	et	PROPN
biomedich-578	36	58	al	al	PROPN
biomedich-578	36	59	.	.	PROPN
biomedich-578	36	60	,	,	PUNCT
biomedich-578	36	61	2022	2022	NUM
biomedich-578	36	62	;	;	PUNCT
biomedich-578	36	63	rivarti	rivarti	PROPN
biomedich-578	36	64	et	et	PROPN
biomedich-578	36	65	al	al	PROPN
biomedich-578	36	66	.	.	PROPN
biomedich-578	36	67	,	,	PUNCT
biomedich-578	36	68	2023	2023	NUM
biomedich-578	36	69	)	)	PUNCT
biomedich-578	36	70	.	.	PUNCT
biomedich-578	37	1	extracellular	extracellular	ADJ
biomedich-578	37	2	amyloid	amyloid	NOUN
biomedich-578	37	3	plaques	plaque	NOUN
biomedich-578	37	4	amyloid	amyloid	NOUN
biomedich-578	37	5	is	be	AUX
biomedich-578	37	6	an	an	DET
biomedich-578	37	7	appealing	appealing	ADJ
biomedich-578	37	8	therapeutic	therapeutic	ADJ
biomedich-578	37	9	target	target	NOUN
biomedich-578	37	10	as	as	SCONJ
biomedich-578	37	11	it	it	PRON
biomedich-578	37	12	is	be	AUX
biomedich-578	37	13	extraneuronal	extraneuronal	ADJ
biomedich-578	37	14	and	and	CCONJ
biomedich-578	37	15	is	be	AUX
biomedich-578	37	16	associated	associate	VERB
biomedich-578	37	17	with	with	ADP
biomedich-578	37	18	environment	environment	NOUN
biomedich-578	37	19	toxicity	toxicity	NOUN
biomedich-578	37	20	(	(	PUNCT
biomedich-578	37	21	mehta	mehta	PROPN
biomedich-578	37	22	et	et	PROPN
biomedich-578	37	23	al	al	PROPN
biomedich-578	37	24	.	.	PROPN
biomedich-578	37	25	,	,	PUNCT
biomedich-578	37	26	2017	2017	NUM
biomedich-578	37	27	)	)	PUNCT
biomedich-578	37	28	.	.	PUNCT
biomedich-578	38	1	the	the	DET
biomedich-578	38	2	inhibition	inhibition	NOUN
biomedich-578	38	3	of	of	ADP
biomedich-578	38	4	amyloid	amyloid	NOUN
biomedich-578	38	5	-	-	PUNCT
biomedich-578	38	6	β	β	X
biomedich-578	38	7	(	(	PUNCT
biomedich-578	38	8	aβ	aβ	NOUN
biomedich-578	38	9	)	)	PUNCT
biomedich-578	38	10	production	production	NOUN
biomedich-578	38	11	and	and	CCONJ
biomedich-578	38	12	plaque	plaque	NOUN
biomedich-578	38	13	formation	formation	NOUN
biomedich-578	38	14	,	,	PUNCT
biomedich-578	38	15	as	as	ADV
biomedich-578	38	16	well	well	ADV
biomedich-578	38	17	as	as	ADP
biomedich-578	38	18	the	the	DET
biomedich-578	38	19	escalation	escalation	NOUN
biomedich-578	38	20	of	of	ADP
biomedich-578	38	21	aβ	aβ	DET
biomedich-578	38	22	degradation	degradation	NOUN
biomedich-578	38	23	and	and	CCONJ
biomedich-578	38	24	clearance	clearance	NOUN
biomedich-578	38	25	,	,	PUNCT
biomedich-578	38	26	are	be	AUX
biomedich-578	38	27	the	the	DET
biomedich-578	38	28	main	main	ADJ
biomedich-578	38	29	goals	goal	NOUN
biomedich-578	38	30	in	in	ADP
biomedich-578	38	31	therapy	therapy	NOUN
biomedich-578	38	32	(	(	PUNCT
biomedich-578	38	33	martins	martin	NOUN
biomedich-578	38	34	et	et	NOUN
biomedich-578	38	35	al	al	PROPN
biomedich-578	38	36	.	.	PROPN
biomedich-578	38	37	,	,	PUNCT
biomedich-578	38	38	2020	2020	NUM
biomedich-578	38	39	)	)	PUNCT
biomedich-578	38	40	.	.	PUNCT
biomedich-578	39	1	amyloid	amyloid	NOUN
biomedich-578	39	2	protein	protein	NOUN
biomedich-578	39	3	precursor	precursor	NOUN
biomedich-578	39	4	(	(	PUNCT
biomedich-578	39	5	app	app	NOUN
biomedich-578	39	6	)	)	PUNCT
biomedich-578	39	7	cleavage	cleavage	NOUN
biomedich-578	39	8	by	by	ADP
biomedich-578	39	9	protease	protease	NOUN
biomedich-578	39	10	enzymes	enzyme	NOUN
biomedich-578	39	11	(	(	PUNCT
biomedich-578	39	12	βsecretase	βsecretase	NOUN
biomedich-578	39	13	and	and	CCONJ
biomedich-578	39	14	then	then	ADV
biomedich-578	39	15	γ	γ	PROPN
biomedich-578	39	16	-	-	PUNCT
biomedich-578	39	17	secretase	secretase	NOUN
biomedich-578	39	18	)	)	PUNCT
biomedich-578	39	19	,	,	PUNCT
biomedich-578	39	20	resulting	result	VERB
biomedich-578	39	21	in	in	ADP
biomedich-578	39	22	the	the	DET
biomedich-578	39	23	production	production	NOUN
biomedich-578	39	24	of	of	ADP
biomedich-578	39	25	amyloidogenic	amyloidogenic	ADJ
biomedich-578	39	26	aβ	aβ	PRON
biomedich-578	39	27	peptides	peptide	NOUN
biomedich-578	39	28	(	(	PUNCT
biomedich-578	39	29	aβ40	aβ40	PROPN
biomedich-578	39	30	,	,	PUNCT
biomedich-578	39	31	aβ42	aβ42	PROPN
biomedich-578	39	32	,	,	PUNCT
biomedich-578	39	33	and	and	CCONJ
biomedich-578	39	34	aβ43	aβ43	PROPN
biomedich-578	39	35	)	)	PUNCT
biomedich-578	39	36	(	(	PUNCT
biomedich-578	39	37	cummings	cummings	PROPN
biomedich-578	39	38	et	et	PROPN
biomedich-578	39	39	al	al	PROPN
biomedich-578	39	40	.	.	PROPN
biomedich-578	39	41	,	,	PUNCT
biomedich-578	39	42	2019	2019	NUM
biomedich-578	39	43	;	;	PUNCT
biomedich-578	39	44	martins	martin	NOUN
biomedich-578	39	45	et	et	NOUN
biomedich-578	39	46	al	al	PROPN
biomedich-578	39	47	.	.	PROPN
biomedich-578	39	48	,	,	PUNCT
biomedich-578	39	49	2020	2020	NUM
biomedich-578	39	50	)	)	PUNCT
biomedich-578	39	51	.	.	PUNCT
biomedich-578	40	1	aβ	aβ	PRON
biomedich-578	40	2	peptides	peptide	NOUN
biomedich-578	40	3	accumulate	accumulate	VERB
biomedich-578	40	4	in	in	ADP
biomedich-578	40	5	the	the	DET
biomedich-578	40	6	central	central	ADJ
biomedich-578	40	7	nervous	nervous	ADJ
biomedich-578	40	8	system	system	NOUN
biomedich-578	40	9	(	(	PUNCT
biomedich-578	40	10	cns	cns	NOUN
biomedich-578	40	11	)	)	PUNCT
biomedich-578	40	12	,	,	PUNCT
biomedich-578	40	13	then	then	ADV
biomedich-578	40	14	undergo	undergo	VERB
biomedich-578	40	15	oligomerization	oligomerization	NOUN
biomedich-578	40	16	and	and	CCONJ
biomedich-578	40	17	fibrillization	fibrillization	NOUN
biomedich-578	40	18	before	before	ADP
biomedich-578	40	19	forming	form	VERB
biomedich-578	40	20	aβ	aβ	DET
biomedich-578	40	21	plaques	plaque	NOUN
biomedich-578	40	22	(	(	PUNCT
biomedich-578	40	23	fereira	fereira	PROPN
biomedich-578	40	24	et	et	PROPN
biomedich-578	40	25	al	al	PROPN
biomedich-578	40	26	.	.	PROPN
biomedich-578	40	27	,	,	PUNCT
biomedich-578	40	28	2022	2022	NUM
biomedich-578	40	29	)	)	PUNCT
biomedich-578	40	30	.	.	PUNCT
biomedich-578	41	1	the	the	DET
biomedich-578	41	2	accumulation	accumulation	NOUN
biomedich-578	41	3	of	of	ADP
biomedich-578	41	4	aβ	aβ	DET
biomedich-578	41	5	plaques	plaque	NOUN
biomedich-578	41	6	causes	cause	VERB
biomedich-578	41	7	synaptic	synaptic	ADJ
biomedich-578	41	8	dysfunction	dysfunction	NOUN
biomedich-578	41	9	and	and	CCONJ
biomedich-578	41	10	neurodegeneration	neurodegeneration	NOUN
biomedich-578	41	11	(	(	PUNCT
biomedich-578	41	12	martins	martin	NOUN
biomedich-578	41	13	et	et	NOUN
biomedich-578	41	14	al	al	PROPN
biomedich-578	41	15	.	.	PROPN
biomedich-578	41	16	,	,	PUNCT
biomedich-578	41	17	2020	2020	NUM
biomedich-578	41	18	)	)	PUNCT
biomedich-578	41	19	.	.	PUNCT
biomedich-578	42	1	overexpression	overexpression	NOUN
biomedich-578	42	2	of	of	ADP
biomedich-578	42	3	β	β	NOUN
biomedich-578	42	4	-	-	NOUN
biomedich-578	42	5	secretase	secretase	ADJ
biomedich-578	42	6	1	1	NUM
biomedich-578	42	7	(	(	PUNCT
biomedich-578	42	8	bace-1	bace-1	PROPN
biomedich-578	42	9	)	)	PUNCT
biomedich-578	42	10	limits	limit	VERB
biomedich-578	42	11	the	the	DET
biomedich-578	42	12	rate	rate	NOUN
biomedich-578	42	13	at	at	ADP
biomedich-578	42	14	the	the	DET
biomedich-578	42	15	β	β	PROPN
biomedich-578	42	16	site	site	NOUN
biomedich-578	42	17	app	app	PROPN
biomedich-578	42	18	,	,	PUNCT
biomedich-578	42	19	thus	thus	ADV
biomedich-578	42	20	reducing	reduce	VERB
biomedich-578	42	21	the	the	DET
biomedich-578	42	22	production	production	NOUN
biomedich-578	42	23	of	of	ADP
biomedich-578	42	24	amyloidogenic	amyloidogenic	ADJ
biomedich-578	42	25	peptides	peptide	NOUN
biomedich-578	42	26	(	(	PUNCT
biomedich-578	42	27	koelsch	koelsch	PROPN
biomedich-578	42	28	,	,	PUNCT
biomedich-578	42	29	2017	2017	NUM
biomedich-578	42	30	;	;	PUNCT
biomedich-578	42	31	martins	martin	NOUN
biomedich-578	42	32	et	et	NOUN
biomedich-578	42	33	al	al	PROPN
biomedich-578	42	34	.	.	PROPN
biomedich-578	42	35	,	,	PUNCT
biomedich-578	42	36	2020	2020	NUM
biomedich-578	42	37	)	)	PUNCT
biomedich-578	42	38	.	.	PUNCT
biomedich-578	43	1	therefore	therefore	ADV
biomedich-578	43	2	,	,	PUNCT
biomedich-578	43	3	inhibiting	inhibit	VERB
biomedich-578	43	4	bace-1	bace-1	PROPN
biomedich-578	43	5	and	and	CCONJ
biomedich-578	43	6	γ	γ	NOUN
biomedich-578	43	7	-	-	PUNCT
biomedich-578	43	8	secretase	secretase	NOUN
biomedich-578	43	9	is	be	AUX
biomedich-578	43	10	necessary	necessary	ADJ
biomedich-578	43	11	to	to	PART
biomedich-578	43	12	prevent	prevent	VERB
biomedich-578	43	13	the	the	DET
biomedich-578	43	14	formation	formation	NOUN
biomedich-578	43	15	of	of	ADP
biomedich-578	43	16	aβ	aβ	PROPN
biomedich-578	43	17	.	.	PROPN
biomedich-578	43	18	app	app	PROPN
biomedich-578	43	19	can	can	AUX
biomedich-578	43	20	also	also	ADV
biomedich-578	43	21	be	be	AUX
biomedich-578	43	22	cleaved	cleave	VERB
biomedich-578	43	23	via	via	ADP
biomedich-578	43	24	the	the	DET
biomedich-578	43	25	non	non	ADJ
biomedich-578	43	26	-	-	ADJ
biomedich-578	43	27	amyloidogenic	amyloidogenic	ADJ
biomedich-578	43	28	pathway	pathway	NOUN
biomedich-578	43	29	involving	involve	VERB
biomedich-578	43	30	the	the	DET
biomedich-578	43	31	enzyme	enzyme	NOUN
biomedich-578	43	32	α	α	NOUN
biomedich-578	43	33	-	-	NOUN
biomedich-578	43	34	secretase	secretase	NOUN
biomedich-578	43	35	.	.	PUNCT
biomedich-578	44	1	conversely	conversely	ADV
biomedich-578	44	2	,	,	PUNCT
biomedich-578	44	3	increasing	increase	VERB
biomedich-578	44	4	αsecretase	αsecretase	NOUN
biomedich-578	44	5	activity	activity	NOUN
biomedich-578	44	6	is	be	AUX
biomedich-578	44	7	required	require	VERB
biomedich-578	44	8	to	to	PART
biomedich-578	44	9	enhance	enhance	VERB
biomedich-578	44	10	the	the	DET
biomedich-578	44	11	formation	formation	NOUN
biomedich-578	44	12	of	of	ADP
biomedich-578	44	13	α	α	NOUN
biomedich-578	44	14	-	-	PUNCT
biomedich-578	44	15	app	app	ADJ
biomedich-578	44	16	,	,	PUNCT
biomedich-578	44	17	a	a	DET
biomedich-578	44	18	potential	potential	ADJ
biomedich-578	44	19	neuroprotective	neuroprotective	ADJ
biomedich-578	44	20	protein	protein	NOUN
biomedich-578	44	21	(	(	PUNCT
biomedich-578	44	22	koelsch	koelsch	PROPN
biomedich-578	44	23	,	,	PUNCT
biomedich-578	44	24	2017	2017	NUM
biomedich-578	44	25	;	;	PUNCT
biomedich-578	44	26	martins	martin	NOUN
biomedich-578	44	27	et	et	NOUN
biomedich-578	44	28	al	al	PROPN
biomedich-578	44	29	.	.	PROPN
biomedich-578	44	30	,	,	PUNCT
biomedich-578	44	31	2020	2020	NUM
biomedich-578	44	32	)	)	PUNCT
biomedich-578	44	33	.	.	PUNCT
biomedich-578	45	1	mutations	mutation	NOUN
biomedich-578	45	2	of	of	ADP
biomedich-578	45	3	the	the	DET
biomedich-578	45	4	app	app	NOUN
biomedich-578	45	5	gene	gene	NOUN
biomedich-578	45	6	,	,	PUNCT
biomedich-578	45	7	which	which	PRON
biomedich-578	45	8	codes	code	VERB
biomedich-578	45	9	for	for	ADP
biomedich-578	45	10	app	app	NOUN
biomedich-578	45	11	substrates	substrate	NOUN
biomedich-578	45	12	,	,	PUNCT
biomedich-578	45	13	contribute	contribute	VERB
biomedich-578	45	14	to	to	ADP
biomedich-578	45	15	the	the	DET
biomedich-578	45	16	increase	increase	NOUN
biomedich-578	45	17	of	of	ADP
biomedich-578	45	18	aβ	aβ	PRON
biomedich-578	45	19	fibrillogenesis	fibrillogenesis	NOUN
biomedich-578	45	20	and	and	CCONJ
biomedich-578	45	21	total	total	ADJ
biomedich-578	45	22	aβ	aβ	NOUN
biomedich-578	45	23	levels	level	NOUN
biomedich-578	45	24	.	.	PUNCT
biomedich-578	46	1	meanwhile	meanwhile	ADV
biomedich-578	46	2	,	,	PUNCT
biomedich-578	46	3	mutations	mutation	NOUN
biomedich-578	46	4	of	of	ADP
biomedich-578	46	5	the	the	DET
biomedich-578	46	6	presenilin	presenilin	NOUN
biomedich-578	46	7	(	(	PUNCT
biomedich-578	46	8	psen-1	psen-1	PROPN
biomedich-578	46	9	and	and	CCONJ
biomedich-578	46	10	psen-2	psen-2	NOUN
biomedich-578	46	11	)	)	PUNCT
biomedich-578	46	12	genes	gene	NOUN
biomedich-578	46	13	which	which	PRON
biomedich-578	46	14	code	code	VERB
biomedich-578	46	15	for	for	ADP
biomedich-578	46	16	proteases	protease	NOUN
biomedich-578	46	17	for	for	ADP
biomedich-578	46	18	cutting	cut	VERB
biomedich-578	46	19	app	app	NOUN
biomedich-578	46	20	are	be	AUX
biomedich-578	46	21	known	know	VERB
biomedich-578	46	22	to	to	PART
biomedich-578	46	23	cause	cause	VERB
biomedich-578	46	24	abnormalities	abnormality	NOUN
biomedich-578	46	25	and	and	CCONJ
biomedich-578	46	26	aβ	aβ	ADP
biomedich-578	46	27	deposition	deposition	NOUN
biomedich-578	46	28	.	.	PUNCT
biomedich-578	47	1	in	in	ADP
biomedich-578	47	2	addition	addition	NOUN
biomedich-578	47	3	,	,	PUNCT
biomedich-578	47	4	the	the	DET
biomedich-578	47	5	presence	presence	NOUN
biomedich-578	47	6	of	of	ADP
biomedich-578	47	7	the	the	DET
biomedich-578	47	8	apolipoprotein	apolipoprotein	ADJ
biomedich-578	47	9	e4	e4	PROPN
biomedich-578	47	10	(	(	PUNCT
biomedich-578	47	11	apoe-4	apoe-4	NOUN
biomedich-578	47	12	)	)	PUNCT
biomedich-578	47	13	allele	allele	NOUN
biomedich-578	47	14	decreases	decrease	VERB
biomedich-578	47	15	aβ	aβ	PRON
biomedich-578	47	16	clearance	clearance	NOUN
biomedich-578	47	17	in	in	ADP
biomedich-578	47	18	brain	brain	NOUN
biomedich-578	47	19	tissue	tissue	NOUN
biomedich-578	47	20	which	which	PRON
biomedich-578	47	21	leads	lead	VERB
biomedich-578	47	22	to	to	ADP
biomedich-578	47	23	the	the	DET
biomedich-578	47	24	accumulation	accumulation	NOUN
biomedich-578	47	25	of	of	ADP
biomedich-578	47	26	aβ	aβ	PRON
biomedich-578	47	27	plaque	plaque	NOUN
biomedich-578	47	28	(	(	PUNCT
biomedich-578	47	29	cacabelos	cacabelo	NOUN
biomedich-578	47	30	,	,	PUNCT
biomedich-578	47	31	2022	2022	NUM
biomedich-578	47	32	)	)	PUNCT
biomedich-578	47	33	.	.	PUNCT
biomedich-578	48	1	the	the	DET
biomedich-578	48	2	initialization	initialization	NOUN
biomedich-578	48	3	of	of	ADP
biomedich-578	48	4	aβ	aβ	PRON
biomedich-578	48	5	plaques	plaque	NOUN
biomedich-578	48	6	can	can	AUX
biomedich-578	48	7	occur	occur	VERB
biomedich-578	48	8	due	due	ADP
biomedich-578	48	9	to	to	ADP
biomedich-578	48	10	the	the	DET
biomedich-578	48	11	binding	binding	NOUN
biomedich-578	48	12	of	of	ADP
biomedich-578	48	13	aβ	aβ	PRON
biomedich-578	48	14	to	to	ADP
biomedich-578	48	15	nicotinic	nicotinic	ADJ
biomedich-578	48	16	acetylcholine	acetylcholine	NOUN
biomedich-578	48	17	receptors	receptor	NOUN
biomedich-578	48	18	(	(	PUNCT
biomedich-578	48	19	nachrs	nachrs	ADJ
biomedich-578	48	20	)	)	PUNCT
biomedich-578	48	21	,	,	PUNCT
biomedich-578	48	22	especially	especially	ADV
biomedich-578	48	23	the	the	DET
biomedich-578	48	24	α7	α7	NOUN
biomedich-578	48	25	subtype	subtype	NOUN
biomedich-578	48	26	,	,	PUNCT
biomedich-578	48	27	leading	lead	VERB
biomedich-578	48	28	to	to	ADP
biomedich-578	48	29	a	a	DET
biomedich-578	48	30	decrease	decrease	NOUN
biomedich-578	48	31	in	in	ADP
biomedich-578	48	32	the	the	DET
biomedich-578	48	33	normal	normal	ADJ
biomedich-578	48	34	function	function	NOUN
biomedich-578	48	35	of	of	ADP
biomedich-578	48	36	these	these	DET
biomedich-578	48	37	receptors	receptor	NOUN
biomedich-578	48	38	.	.	PUNCT
biomedich-578	49	1	oligomerization	oligomerization	NOUN
biomedich-578	49	2	of	of	ADP
biomedich-578	49	3	aβ	aβ	PRON
biomedich-578	49	4	resulting	result	VERB
biomedich-578	49	5	from	from	ADP
biomedich-578	49	6	nachr	nachr	PROPN
biomedich-578	49	7	activation	activation	NOUN
biomedich-578	49	8	is	be	AUX
biomedich-578	49	9	also	also	ADV
biomedich-578	49	10	known	know	VERB
biomedich-578	49	11	to	to	PART
biomedich-578	49	12	induce	induce	VERB
biomedich-578	49	13	phosphorylation	phosphorylation	NOUN
biomedich-578	49	14	of	of	ADP
biomedich-578	49	15	tau	tau	PROPN
biomedich-578	49	16	proteins	protein	NOUN
biomedich-578	49	17	(	(	PUNCT
biomedich-578	49	18	kabir	kabir	PROPN
biomedich-578	49	19	et	et	PROPN
biomedich-578	49	20	al	al	PROPN
biomedich-578	49	21	.	.	PROPN
biomedich-578	49	22	,	,	PUNCT
biomedich-578	49	23	2021	2021	NUM
biomedich-578	49	24	)	)	PUNCT
biomedich-578	49	25	.	.	PUNCT
biomedich-578	50	1	therefore	therefore	ADV
biomedich-578	50	2	,	,	PUNCT
biomedich-578	50	3	nicotinic	nicotinic	ADJ
biomedich-578	50	4	agonists	agonist	NOUN
biomedich-578	50	5	can	can	AUX
biomedich-578	50	6	be	be	AUX
biomedich-578	50	7	used	use	VERB
biomedich-578	50	8	as	as	ADP
biomedich-578	50	9	therapeutic	therapeutic	ADJ
biomedich-578	50	10	agents	agent	NOUN
biomedich-578	50	11	for	for	ADP
biomedich-578	50	12	ad	ad	NOUN
biomedich-578	50	13	(	(	PUNCT
biomedich-578	50	14	martins	martin	NOUN
biomedich-578	50	15	et	et	NOUN
biomedich-578	50	16	al	al	PROPN
biomedich-578	50	17	.	.	PROPN
biomedich-578	50	18	,	,	PUNCT
biomedich-578	50	19	2020	2020	NUM
biomedich-578	50	20	)	)	PUNCT
biomedich-578	50	21	.	.	PUNCT
biomedich-578	51	1	the	the	DET
biomedich-578	51	2	aβ	aβ	NOUN
biomedich-578	51	3	plaque	plaque	NOUN
biomedich-578	51	4	and	and	CCONJ
biomedich-578	51	5	the	the	DET
biomedich-578	51	6	persistent	persistent	ADJ
biomedich-578	51	7	single	single	ADJ
biomedich-578	51	8	shot	shot	NOUN
biomedich-578	51	9	of	of	ADP
biomedich-578	51	10	proinflammatory	proinflammatory	ADJ
biomedich-578	51	11	cytokines	cytokine	NOUN
biomedich-578	51	12	damage	damage	NOUN
biomedich-578	51	13	neurons	neuron	NOUN
biomedich-578	51	14	and	and	CCONJ
biomedich-578	51	15	lead	lead	VERB
biomedich-578	51	16	to	to	ADP
biomedich-578	51	17	cell	cell	NOUN
biomedich-578	51	18	death	death	NOUN
biomedich-578	51	19	(	(	PUNCT
biomedich-578	51	20	martins	martin	NOUN
biomedich-578	51	21	et	et	NOUN
biomedich-578	51	22	al	al	PROPN
biomedich-578	51	23	.	.	PROPN
biomedich-578	51	24	,	,	PUNCT
biomedich-578	51	25	2020	2020	NUM
biomedich-578	51	26	;	;	PUNCT
biomedich-578	51	27	hu	hu	PROPN
biomedich-578	51	28	et	et	PROPN
biomedich-578	51	29	al	al	PROPN
biomedich-578	51	30	.	.	PROPN
biomedich-578	51	31	,	,	PUNCT
biomedich-578	51	32	2023	2023	NUM
biomedich-578	51	33	)	)	PUNCT
biomedich-578	51	34	.	.	PUNCT
biomedich-578	52	1	for	for	ADP
biomedich-578	52	2	this	this	DET
biomedich-578	52	3	reason	reason	NOUN
biomedich-578	52	4	,	,	PUNCT
biomedich-578	52	5	therapy	therapy	NOUN
biomedich-578	52	6	targeted	target	VERB
biomedich-578	52	7	at	at	ADP
biomedich-578	52	8	reducing	reduce	VERB
biomedich-578	52	9	aβ	aβ	PRON
biomedich-578	52	10	accumulation	accumulation	NOUN
biomedich-578	52	11	and	and	CCONJ
biomedich-578	52	12	slowing	slow	VERB
biomedich-578	52	13	the	the	DET
biomedich-578	52	14	decline	decline	NOUN
biomedich-578	52	15	in	in	ADP
biomedich-578	52	16	cognitive	cognitive	ADJ
biomedich-578	52	17	function	function	NOUN
biomedich-578	52	18	in	in	ADP
biomedich-578	52	19	presymptomatic	presymptomatic	ADJ
biomedich-578	52	20	or	or	CCONJ
biomedich-578	52	21	mild	mild	ADJ
biomedich-578	52	22	ad	ad	NOUN
biomedich-578	52	23	is	be	AUX
biomedich-578	52	24	an	an	DET
biomedich-578	52	25	appropriate	appropriate	ADJ
biomedich-578	52	26	pharmacological	pharmacological	NOUN
biomedich-578	52	27	intervention	intervention	NOUN
biomedich-578	52	28	.	.	PUNCT
biomedich-578	53	1	intracellular	intracellular	ADJ
biomedich-578	53	2	tau	tau	PROPN
biomedich-578	53	3	neurofibrillary	neurofibrillary	ADJ
biomedich-578	53	4	tangles	tangle	NOUN
biomedich-578	53	5	(	(	PUNCT
biomedich-578	53	6	nfts	nft	NOUN
biomedich-578	53	7	)	)	PUNCT
biomedich-578	53	8	neurofibrillary	neurofibrillary	ADJ
biomedich-578	53	9	tangles	tangle	NOUN
biomedich-578	53	10	(	(	PUNCT
biomedich-578	53	11	nfts	nft	NOUN
biomedich-578	53	12	)	)	PUNCT
biomedich-578	53	13	are	be	AUX
biomedich-578	53	14	twisted	twisted	ADJ
biomedich-578	53	15	fibres	fibre	NOUN
biomedich-578	53	16	composed	compose	VERB
biomedich-578	53	17	of	of	ADP
biomedich-578	53	18	hyperphosphorylated	hyperphosphorylated	ADJ
biomedich-578	53	19	tau	tau	PROPN
biomedich-578	53	20	(	(	PUNCT
biomedich-578	53	21	the	the	DET
biomedich-578	53	22	microtubuleassociated	microtubuleassociate	VERB
biomedich-578	53	23	)	)	PUNCT
biomedich-578	53	24	protein	protein	NOUN
biomedich-578	53	25	that	that	PRON
biomedich-578	53	26	accumulates	accumulate	VERB
biomedich-578	53	27	inside	inside	ADJ
biomedich-578	53	28	neurons	neuron	NOUN
biomedich-578	53	29	.	.	PUNCT
biomedich-578	54	1	the	the	DET
biomedich-578	54	2	presence	presence	NOUN
biomedich-578	54	3	of	of	ADP
biomedich-578	54	4	nfts	nft	NOUN
biomedich-578	54	5	blocks	block	VERB
biomedich-578	54	6	the	the	DET
biomedich-578	54	7	transport	transport	NOUN
biomedich-578	54	8	of	of	ADP
biomedich-578	54	9	nutrients	nutrient	NOUN
biomedich-578	54	10	and	and	CCONJ
biomedich-578	54	11	other	other	ADJ
biomedich-578	54	12	essential	essential	ADJ
biomedich-578	54	13	elements	element	NOUN
biomedich-578	54	14	into	into	ADP
biomedich-578	54	15	the	the	DET
biomedich-578	54	16	neuron	neuron	NOUN
biomedich-578	54	17	,	,	PUNCT
biomedich-578	54	18	resulting	result	VERB
biomedich-578	54	19	in	in	ADP
biomedich-578	54	20	cell	cell	NOUN
biomedich-578	54	21	death	death	NOUN
biomedich-578	54	22	.	.	PUNCT
biomedich-578	55	1	glycogen	glycogen	NOUN
biomedich-578	55	2	synthase	synthase	PROPN
biomedich-578	55	3	kinase	kinase	PROPN
biomedich-578	55	4	3β	3β	NUM
biomedich-578	55	5	(	(	PUNCT
biomedich-578	55	6	gsk-3β	gsk-3β	PROPN
biomedich-578	55	7	)	)	PUNCT
biomedich-578	55	8	is	be	AUX
biomedich-578	55	9	the	the	DET
biomedich-578	55	10	main	main	ADJ
biomedich-578	55	11	enzyme	enzyme	NOUN
biomedich-578	55	12	that	that	PRON
biomedich-578	55	13	plays	play	VERB
biomedich-578	55	14	a	a	DET
biomedich-578	55	15	vital	vital	ADJ
biomedich-578	55	16	role	role	NOUN
biomedich-578	55	17	in	in	ADP
biomedich-578	55	18	the	the	DET
biomedich-578	55	19	phosphorylation	phosphorylation	NOUN
biomedich-578	55	20	of	of	ADP
biomedich-578	55	21	tau	tau	PROPN
biomedich-578	55	22	protein	protein	NOUN
biomedich-578	55	23	(	(	PUNCT
biomedich-578	55	24	martins	martin	NOUN
biomedich-578	55	25	et	et	NOUN
biomedich-578	55	26	al	al	PROPN
biomedich-578	55	27	.	.	PROPN
biomedich-578	55	28	,	,	PUNCT
biomedich-578	55	29	2020	2020	NUM
biomedich-578	55	30	;	;	PUNCT
biomedich-578	55	31	silva	silva	PROPN
biomedich-578	55	32	et	et	PROPN
biomedich-578	55	33	al	al	PROPN
biomedich-578	55	34	.	.	PROPN
biomedich-578	55	35	,	,	PUNCT
biomedich-578	55	36	2021	2021	NUM
biomedich-578	55	37	;	;	PUNCT
biomedich-578	55	38	sayas	sayas	NOUN
biomedich-578	55	39	&	&	CCONJ
biomedich-578	55	40	ávila	ávila	PROPN
biomedich-578	55	41	,	,	PUNCT
biomedich-578	55	42	2021	2021	NUM
biomedich-578	55	43	)	)	PUNCT
biomedich-578	55	44	.	.	PUNCT
biomedich-578	56	1	gsk-3β	gsk-3β	PROPN
biomedich-578	56	2	is	be	AUX
biomedich-578	56	3	also	also	ADV
biomedich-578	56	4	a	a	DET
biomedich-578	56	5	molecular	molecular	ADJ
biomedich-578	56	6	connection	connection	NOUN
biomedich-578	56	7	between	between	ADP
biomedich-578	56	8	aβ	aβ	PROPN
biomedich-578	56	9	and	and	CCONJ
biomedich-578	56	10	tau	tau	PROPN
biomedich-578	56	11	in	in	ADP
biomedich-578	56	12	ad	ad	NOUN
biomedich-578	56	13	pathogenesis	pathogenesis	NOUN
biomedich-578	56	14	.	.	PUNCT
biomedich-578	57	1	polymerization	polymerization	NOUN
biomedich-578	57	2	of	of	ADP
biomedich-578	57	3	aβ	aβ	NOUN
biomedich-578	57	4	peptides	peptide	NOUN
biomedich-578	57	5	activates	activate	VERB
biomedich-578	57	6	gsk-3β	gsk-3β	PROPN
biomedich-578	57	7	,	,	PUNCT
biomedich-578	57	8	promoting	promote	VERB
biomedich-578	57	9	tau	tau	PROPN
biomedich-578	57	10	protein	protein	NOUN
biomedich-578	57	11	phosphorylation	phosphorylation	NOUN
biomedich-578	57	12	(	(	PUNCT
biomedich-578	57	13	hu	hu	PROPN
biomedich-578	57	14	et	et	PROPN
biomedich-578	57	15	al	al	PROPN
biomedich-578	57	16	.	.	PROPN
biomedich-578	57	17	,	,	PUNCT
biomedich-578	57	18	2023	2023	NUM
biomedich-578	57	19	)	)	PUNCT
biomedich-578	57	20	.	.	PUNCT
biomedich-578	58	1	on	on	ADP
biomedich-578	58	2	the	the	DET
biomedich-578	58	3	other	other	ADJ
biomedich-578	58	4	hand	hand	NOUN
biomedich-578	58	5	,	,	PUNCT
biomedich-578	58	6	gsk-3β	gsk-3β	PROPN
biomedich-578	58	7	also	also	ADV
biomedich-578	58	8	regulates	regulate	VERB
biomedich-578	58	9	app	app	NOUN
biomedich-578	58	10	metabolism	metabolism	NOUN
biomedich-578	58	11	and	and	CCONJ
biomedich-578	58	12	aβ	aβ	DET
biomedich-578	58	13	production	production	NOUN
biomedich-578	58	14	,	,	PUNCT
biomedich-578	58	15	reducing	reduce	VERB
biomedich-578	58	16	aβ	aβ	PRON
biomedich-578	58	17	deposition	deposition	NOUN
biomedich-578	58	18	and	and	CCONJ
biomedich-578	58	19	plaque	plaque	NOUN
biomedich-578	58	20	formation	formation	NOUN
biomedich-578	58	21	.	.	PUNCT
biomedich-578	59	1	therefore	therefore	ADV
biomedich-578	59	2	,	,	PUNCT
biomedich-578	59	3	inhibiting	inhibit	VERB
biomedich-578	59	4	gsk-3β	gsk-3β	NOUN
biomedich-578	59	5	becomes	become	VERB
biomedich-578	59	6	one	one	NUM
biomedich-578	59	7	of	of	ADP
biomedich-578	59	8	the	the	DET
biomedich-578	59	9	critical	critical	ADJ
biomedich-578	59	10	targets	target	NOUN
biomedich-578	59	11	in	in	ADP
biomedich-578	59	12	the	the	DET
biomedich-578	59	13	development	development	NOUN
biomedich-578	59	14	of	of	ADP
biomedich-578	59	15	ad	ad	NOUN
biomedich-578	59	16	treatment	treatment	NOUN
biomedich-578	59	17	(	(	PUNCT
biomedich-578	59	18	sayas	sayas	NOUN
biomedich-578	59	19	&	&	CCONJ
biomedich-578	59	20	ávila	ávila	PROPN
biomedich-578	59	21	,	,	PUNCT
biomedich-578	59	22	2021	2021	NUM
biomedich-578	59	23	)	)	PUNCT
biomedich-578	59	24	.	.	PUNCT
biomedich-578	60	1	setiawan	setiawan	PROPN
biomedich-578	60	2	et	et	PROPN
biomedich-578	60	3	al	al	PROPN
biomedich-578	60	4	.	.	PROPN
biomedich-578	60	5	–	–	PUNCT
biomedich-578	60	6	physicochemical	physicochemical	ADJ
biomedich-578	60	7	candy	candy	NOUN
biomedich-578	60	8	cinnamon	cinnamon	NOUN
biomedich-578	60	9	seaweed	seaweed	NOUN
biomedich-578	60	10	carrageenan	carrageenan	NOUN
biomedich-578	60	11	.	.	PUNCT
biomedich-578	61	1	435	435	NUM
biomedich-578	61	2	gsk-3β	gsk-3β	PROPN
biomedich-578	61	3	can	can	AUX
biomedich-578	61	4	be	be	AUX
biomedich-578	61	5	inhibited	inhibit	VERB
biomedich-578	61	6	by	by	ADP
biomedich-578	61	7	activation	activation	NOUN
biomedich-578	61	8	of	of	ADP
biomedich-578	61	9	protein	protein	NOUN
biomedich-578	61	10	kinase	kinase	PROPN
biomedich-578	61	11	c	c	PROPN
biomedich-578	61	12	(	(	PUNCT
biomedich-578	61	13	pkc	pkc	PROPN
biomedich-578	61	14	)	)	PUNCT
biomedich-578	61	15	,	,	PUNCT
biomedich-578	61	16	one	one	NUM
biomedich-578	61	17	of	of	ADP
biomedich-578	61	18	which	which	PRON
biomedich-578	61	19	can	can	AUX
biomedich-578	61	20	be	be	AUX
biomedich-578	61	21	stimulated	stimulate	VERB
biomedich-578	61	22	by	by	ADP
biomedich-578	61	23	acetylcholine	acetylcholine	NOUN
biomedich-578	61	24	(	(	PUNCT
biomedich-578	61	25	ach	ach	PROPN
biomedich-578	61	26	)	)	PUNCT
biomedich-578	61	27	.	.	PUNCT
biomedich-578	62	1	thus	thus	ADV
biomedich-578	62	2	,	,	PUNCT
biomedich-578	62	3	an	an	DET
biomedich-578	62	4	increase	increase	NOUN
biomedich-578	62	5	in	in	ADP
biomedich-578	62	6	ach	ach	PROPN
biomedich-578	62	7	levels	level	NOUN
biomedich-578	62	8	can	can	AUX
biomedich-578	62	9	indirectly	indirectly	ADV
biomedich-578	62	10	inhibit	inhibit	VERB
biomedich-578	62	11	gsk-3β	gsk-3β	PROPN
biomedich-578	62	12	(	(	PUNCT
biomedich-578	62	13	martins	martin	NOUN
biomedich-578	62	14	et	et	NOUN
biomedich-578	62	15	al	al	PROPN
biomedich-578	62	16	.	.	PROPN
biomedich-578	62	17	,	,	PUNCT
biomedich-578	62	18	2020	2020	NUM
biomedich-578	62	19	)	)	PUNCT
biomedich-578	62	20	.	.	PUNCT
biomedich-578	63	1	in	in	ADP
biomedich-578	63	2	addition	addition	NOUN
biomedich-578	63	3	,	,	PUNCT
biomedich-578	63	4	tau	tau	PROPN
biomedich-578	63	5	protein	protein	NOUN
biomedich-578	63	6	is	be	AUX
biomedich-578	63	7	encoded	encode	VERB
biomedich-578	63	8	by	by	ADP
biomedich-578	63	9	a	a	DET
biomedich-578	63	10	single	single	ADJ
biomedich-578	63	11	-	-	PUNCT
biomedich-578	63	12	copy	copy	NOUN
biomedich-578	63	13	gene	gene	NOUN
biomedich-578	63	14	called	call	VERB
biomedich-578	63	15	microtubule	microtubule	NOUN
biomedich-578	63	16	-	-	PUNCT
biomedich-578	63	17	associated	associate	VERB
biomedich-578	63	18	protein	protein	NOUN
biomedich-578	63	19	tau	tau	PROPN
biomedich-578	63	20	(	(	PUNCT
biomedich-578	63	21	mapt	mapt	NOUN
biomedich-578	63	22	)	)	PUNCT
biomedich-578	63	23	.	.	PUNCT
biomedich-578	64	1	this	this	DET
biomedich-578	64	2	gene	gene	NOUN
biomedich-578	64	3	mutation	mutation	NOUN
biomedich-578	64	4	can	can	AUX
biomedich-578	64	5	lead	lead	VERB
biomedich-578	64	6	to	to	ADP
biomedich-578	64	7	nft	nft	PROPN
biomedich-578	64	8	formation	formation	NOUN
biomedich-578	64	9	(	(	PUNCT
biomedich-578	64	10	cacabelos	cacabelos	NOUN
biomedich-578	64	11	,	,	PUNCT
biomedich-578	64	12	2022	2022	NUM
biomedich-578	64	13	)	)	PUNCT
biomedich-578	64	14	.	.	PUNCT
biomedich-578	65	1	figure	figure	NOUN
biomedich-578	65	2	1	1	NUM
biomedich-578	65	3	.	.	PUNCT
biomedich-578	66	1	the	the	DET
biomedich-578	66	2	main	main	ADJ
biomedich-578	66	3	target	target	NOUN
biomedich-578	66	4	for	for	ADP
biomedich-578	66	5	marine	marine	ADJ
biomedich-578	66	6	natural	natural	ADJ
biomedich-578	66	7	products	product	NOUN
biomedich-578	66	8	(	(	PUNCT
biomedich-578	66	9	mnps	mnps	PROPN
biomedich-578	66	10	)	)	PUNCT
biomedich-578	66	11	as	as	ADP
biomedich-578	66	12	drug	drug	NOUN
biomedich-578	66	13	-	-	PUNCT
biomedich-578	66	14	modifying	modify	VERB
biomedich-578	66	15	treatment	treatment	NOUN
biomedich-578	66	16	(	(	PUNCT
biomedich-578	66	17	dmts	dmts	NOUN
biomedich-578	66	18	)	)	PUNCT
biomedich-578	66	19	for	for	ADP
biomedich-578	66	20	alzheimer	alzheimer	PROPN
biomedich-578	66	21	’s	’s	PART
biomedich-578	66	22	disease	disease	NOUN
biomedich-578	66	23	(	(	PUNCT
biomedich-578	66	24	ad	ad	NOUN
biomedich-578	66	25	)	)	PUNCT
biomedich-578	66	26	.	.	PUNCT
biomedich-578	67	1	these	these	DET
biomedich-578	67	2	targets	target	NOUN
biomedich-578	67	3	are	be	AUX
biomedich-578	67	4	:	:	PUNCT
biomedich-578	67	5	(	(	PUNCT
biomedich-578	67	6	1	1	X
biomedich-578	67	7	)	)	PUNCT
biomedich-578	67	8	extracellular	extracellular	ADJ
biomedich-578	67	9	amyloid	amyloid	NOUN
biomedich-578	67	10	plaque	plaque	NOUN
biomedich-578	67	11	,	,	PUNCT
biomedich-578	67	12	(	(	PUNCT
biomedich-578	67	13	2	2	NUM
biomedich-578	67	14	)	)	PUNCT
biomedich-578	67	15	intracellular	intracellular	ADJ
biomedich-578	67	16	neurofibrillary	neurofibrillary	ADJ
biomedich-578	67	17	tangles	tangle	NOUN
biomedich-578	67	18	,	,	PUNCT
biomedich-578	67	19	(	(	PUNCT
biomedich-578	67	20	3	3	X
biomedich-578	67	21	)	)	PUNCT
biomedich-578	67	22	neuroinflammation	neuroinflammation	NOUN
biomedich-578	67	23	,	,	PUNCT
biomedich-578	67	24	and	and	CCONJ
biomedich-578	67	25	(	(	PUNCT
biomedich-578	67	26	4	4	X
biomedich-578	67	27	)	)	PUNCT
biomedich-578	67	28	oxidative	oxidative	ADJ
biomedich-578	67	29	stress	stress	NOUN
biomedich-578	67	30	.	.	PUNCT
biomedich-578	68	1	neuroinflammation	neuroinflammation	NOUN
biomedich-578	68	2	aβ	aβ	NOUN
biomedich-578	68	3	plaques	plaque	NOUN
biomedich-578	68	4	and	and	CCONJ
biomedich-578	68	5	nfts	nft	NOUN
biomedich-578	68	6	cause	cause	VERB
biomedich-578	68	7	an	an	DET
biomedich-578	68	8	immune	immune	ADJ
biomedich-578	68	9	system	system	NOUN
biomedich-578	68	10	response	response	NOUN
biomedich-578	68	11	that	that	PRON
biomedich-578	68	12	activates	activate	VERB
biomedich-578	68	13	microglia	microglia	NOUN
biomedich-578	68	14	(	(	PUNCT
biomedich-578	68	15	martins	martin	NOUN
biomedich-578	68	16	et	et	NOUN
biomedich-578	68	17	al	al	PROPN
biomedich-578	68	18	.	.	PROPN
biomedich-578	68	19	,	,	PUNCT
biomedich-578	68	20	2020	2020	NUM
biomedich-578	68	21	;	;	PUNCT
biomedich-578	68	22	hu	hu	PROPN
biomedich-578	68	23	et	et	PROPN
biomedich-578	68	24	al	al	PROPN
biomedich-578	68	25	.	.	PROPN
biomedich-578	68	26	,	,	PUNCT
biomedich-578	68	27	2023	2023	NUM
biomedich-578	68	28	)	)	PUNCT
biomedich-578	68	29	.	.	PUNCT
biomedich-578	69	1	microglia	microglia	ADJ
biomedich-578	69	2	cells	cell	NOUN
biomedich-578	69	3	are	be	AUX
biomedich-578	69	4	gathered	gather	VERB
biomedich-578	69	5	to	to	PART
biomedich-578	69	6	remove	remove	VERB
biomedich-578	69	7	the	the	DET
biomedich-578	69	8	noxious	noxious	ADJ
biomedich-578	69	9	compounds	compound	NOUN
biomedich-578	69	10	,	,	PUNCT
biomedich-578	69	11	but	but	CCONJ
biomedich-578	69	12	when	when	SCONJ
biomedich-578	69	13	elimination	elimination	NOUN
biomedich-578	69	14	is	be	AUX
biomedich-578	69	15	overwhelmed	overwhelm	VERB
biomedich-578	69	16	by	by	ADP
biomedich-578	69	17	excessive	excessive	ADJ
biomedich-578	69	18	production	production	NOUN
biomedich-578	69	19	,	,	PUNCT
biomedich-578	69	20	inflammation	inflammation	NOUN
biomedich-578	69	21	occurs	occur	VERB
biomedich-578	69	22	(	(	PUNCT
biomedich-578	69	23	martins	martin	NOUN
biomedich-578	69	24	et	et	NOUN
biomedich-578	69	25	al	al	PROPN
biomedich-578	69	26	.	.	PROPN
biomedich-578	69	27	,	,	PUNCT
biomedich-578	69	28	2020	2020	NUM
biomedich-578	69	29	)	)	PUNCT
biomedich-578	69	30	.	.	PUNCT
biomedich-578	70	1	long	long	ADJ
biomedich-578	70	2	-	-	PUNCT
biomedich-578	70	3	term	term	NOUN
biomedich-578	70	4	microglia	microglia	ADJ
biomedich-578	70	5	activation	activation	NOUN
biomedich-578	70	6	leads	lead	VERB
biomedich-578	70	7	to	to	ADP
biomedich-578	70	8	the	the	DET
biomedich-578	70	9	accumulation	accumulation	NOUN
biomedich-578	70	10	of	of	ADP
biomedich-578	70	11	aβ	aβ	PRON
biomedich-578	70	12	and	and	CCONJ
biomedich-578	70	13	prolonged	prolong	VERB
biomedich-578	70	14	inflammation	inflammation	NOUN
biomedich-578	70	15	that	that	SCONJ
biomedich-578	70	16	damages	damage	VERB
biomedich-578	70	17	neurons	neuron	NOUN
biomedich-578	70	18	and	and	CCONJ
biomedich-578	70	19	causes	cause	VERB
biomedich-578	70	20	excessive	excessive	ADJ
biomedich-578	70	21	phosphorylation	phosphorylation	NOUN
biomedich-578	70	22	of	of	ADP
biomedich-578	70	23	tau	tau	PROPN
biomedich-578	70	24	protein	protein	NOUN
biomedich-578	70	25	(	(	PUNCT
biomedich-578	70	26	hu	hu	PROPN
biomedich-578	70	27	et	et	PROPN
biomedich-578	70	28	al	al	PROPN
biomedich-578	70	29	.	.	PROPN
biomedich-578	70	30	,	,	PUNCT
biomedich-578	70	31	2023	2023	NUM
biomedich-578	70	32	)	)	PUNCT
biomedich-578	70	33	.	.	PUNCT
biomedich-578	71	1	downregulation	downregulation	NOUN
biomedich-578	71	2	of	of	ADP
biomedich-578	71	3	tyrosine	tyrosine	NOUN
biomedich-578	71	4	kinase	kinase	PROPN
biomedich-578	71	5	represents	represent	VERB
biomedich-578	71	6	a	a	DET
biomedich-578	71	7	valid	valid	ADJ
biomedich-578	71	8	mechanism	mechanism	NOUN
biomedich-578	71	9	for	for	ADP
biomedich-578	71	10	improving	improve	VERB
biomedich-578	71	11	autophagic	autophagic	ADJ
biomedich-578	71	12	clearance	clearance	NOUN
biomedich-578	71	13	of	of	ADP
biomedich-578	71	14	neurotoxic	neurotoxic	ADJ
biomedich-578	71	15	elements	element	NOUN
biomedich-578	71	16	such	such	ADJ
biomedich-578	71	17	aβ	aβ	ADP
biomedich-578	71	18	and	and	CCONJ
biomedich-578	71	19	mitigating	mitigate	VERB
biomedich-578	71	20	microglialmediated	microglialmediate	VERB
biomedich-578	71	21	inflammation	inflammation	NOUN
biomedich-578	71	22	(	(	PUNCT
biomedich-578	71	23	stevenson	stevenson	PROPN
biomedich-578	71	24	et	et	PROPN
biomedich-578	71	25	al	al	PROPN
biomedich-578	71	26	.	.	PROPN
biomedich-578	71	27	,	,	PUNCT
biomedich-578	71	28	2022	2022	NUM
biomedich-578	71	29	)	)	PUNCT
biomedich-578	71	30	.	.	PUNCT
biomedich-578	72	1	neuroinflammation	neuroinflammation	NOUN
biomedich-578	72	2	is	be	AUX
biomedich-578	72	3	known	know	VERB
biomedich-578	72	4	to	to	PART
biomedich-578	72	5	be	be	AUX
biomedich-578	72	6	mediated	mediate	VERB
biomedich-578	72	7	by	by	ADP
biomedich-578	72	8	advanced	advanced	ADJ
biomedich-578	72	9	glycation	glycation	NOUN
biomedich-578	72	10	endproducts	endproduct	NOUN
biomedich-578	72	11	(	(	PUNCT
biomedich-578	72	12	ages	age	NOUN
biomedich-578	72	13	)	)	PUNCT
biomedich-578	72	14	.	.	PUNCT
biomedich-578	73	1	ages	age	NOUN
biomedich-578	73	2	can	can	AUX
biomedich-578	73	3	bind	bind	VERB
biomedich-578	73	4	to	to	ADP
biomedich-578	73	5	their	their	PRON
biomedich-578	73	6	receptor	receptor	NOUN
biomedich-578	73	7	called	call	VERB
biomedich-578	73	8	rage	rage	NOUN
biomedich-578	73	9	(	(	PUNCT
biomedich-578	73	10	receptors	receptor	NOUN
biomedich-578	73	11	for	for	ADP
biomedich-578	73	12	advanced	advanced	ADJ
biomedich-578	73	13	glycation	glycation	NOUN
biomedich-578	73	14	endproducts	endproduct	NOUN
biomedich-578	73	15	)	)	PUNCT
biomedich-578	73	16	,	,	PUNCT
biomedich-578	73	17	leading	lead	VERB
biomedich-578	73	18	to	to	ADP
biomedich-578	73	19	the	the	DET
biomedich-578	73	20	activation	activation	NOUN
biomedich-578	73	21	of	of	ADP
biomedich-578	73	22	nfκb	nfκb	NOUN
biomedich-578	73	23	,	,	PUNCT
biomedich-578	73	24	a	a	DET
biomedich-578	73	25	pro	pro	ADJ
biomedich-578	73	26	-	-	ADJ
biomedich-578	73	27	inflammatory	inflammatory	ADJ
biomedich-578	73	28	transcription	transcription	NOUN
biomedich-578	73	29	factor	factor	NOUN
biomedich-578	73	30	.	.	PUNCT
biomedich-578	74	1	nfκb	nfκb	ADJ
biomedich-578	74	2	activation	activation	NOUN
biomedich-578	74	3	can	can	AUX
biomedich-578	74	4	affect	affect	VERB
biomedich-578	74	5	two	two	NUM
biomedich-578	74	6	things	thing	NOUN
biomedich-578	74	7	,	,	PUNCT
biomedich-578	74	8	namely	namely	ADV
biomedich-578	74	9	inducing	induce	VERB
biomedich-578	74	10	the	the	DET
biomedich-578	74	11	expression	expression	NOUN
biomedich-578	74	12	of	of	ADP
biomedich-578	74	13	pro	pro	ADJ
biomedich-578	74	14	-	-	ADJ
biomedich-578	74	15	inflammatory	inflammatory	ADJ
biomedich-578	74	16	cytokines	cytokine	NOUN
biomedich-578	74	17	such	such	ADJ
biomedich-578	74	18	as	as	ADP
biomedich-578	74	19	interleukin	interleukin	NOUN
biomedich-578	74	20	(	(	PUNCT
biomedich-578	74	21	il)-1β	il)-1β	PROPN
biomedich-578	74	22	,	,	PUNCT
biomedich-578	74	23	il-6	il-6	PRON
biomedich-578	74	24	,	,	PUNCT
biomedich-578	74	25	and	and	CCONJ
biomedich-578	74	26	tumour	tumour	NOUN
biomedich-578	74	27	necrosis	necrosis	NOUN
biomedich-578	74	28	factor	factor	NOUN
biomedich-578	74	29	-	-	PUNCT
biomedich-578	74	30	alpha	alpha	NOUN
biomedich-578	74	31	(	(	PUNCT
biomedich-578	74	32	tnfα	tnfα	NOUN
biomedich-578	74	33	)	)	PUNCT
biomedich-578	74	34	,	,	PUNCT
biomedich-578	74	35	and	and	CCONJ
biomedich-578	74	36	in	in	ADP
biomedich-578	74	37	turn	turn	NOUN
biomedich-578	74	38	,	,	PUNCT
biomedich-578	74	39	can	can	AUX
biomedich-578	74	40	increase	increase	VERB
biomedich-578	74	41	oxidative	oxidative	ADJ
biomedich-578	74	42	stress	stress	NOUN
biomedich-578	74	43	due	due	ADP
biomedich-578	74	44	to	to	ADP
biomedich-578	74	45	the	the	DET
biomedich-578	74	46	production	production	NOUN
biomedich-578	74	47	of	of	ADP
biomedich-578	74	48	reactive	reactive	ADJ
biomedich-578	74	49	oxygen	oxygen	NOUN
biomedich-578	74	50	species	specie	NOUN
biomedich-578	74	51	(	(	PUNCT
biomedich-578	74	52	ros	ros	PROPN
biomedich-578	74	53	)	)	PUNCT
biomedich-578	74	54	induced	induce	VERB
biomedich-578	74	55	by	by	ADP
biomedich-578	74	56	the	the	DET
biomedich-578	74	57	inflammatory	inflammatory	ADJ
biomedich-578	74	58	response	response	NOUN
biomedich-578	74	59	.	.	PUNCT
biomedich-578	75	1	on	on	ADP
biomedich-578	75	2	the	the	DET
biomedich-578	75	3	other	other	ADJ
biomedich-578	75	4	hand	hand	NOUN
biomedich-578	75	5	,	,	PUNCT
biomedich-578	75	6	this	this	DET
biomedich-578	75	7	oxidative	oxidative	ADJ
biomedich-578	75	8	stress	stress	NOUN
biomedich-578	75	9	,	,	PUNCT
biomedich-578	75	10	in	in	ADP
biomedich-578	75	11	a	a	DET
biomedich-578	75	12	cyclic	cyclic	ADJ
biomedich-578	75	13	manner	manner	NOUN
biomedich-578	75	14	,	,	PUNCT
biomedich-578	75	15	can	can	AUX
biomedich-578	75	16	cause	cause	VERB
biomedich-578	75	17	a	a	DET
biomedich-578	75	18	dramatic	dramatic	ADJ
biomedich-578	75	19	increase	increase	NOUN
biomedich-578	75	20	in	in	ADP
biomedich-578	75	21	the	the	DET
biomedich-578	75	22	amount	amount	NOUN
biomedich-578	75	23	of	of	ADP
biomedich-578	75	24	ages	age	NOUN
biomedich-578	75	25	(	(	PUNCT
biomedich-578	75	26	kong	kong	PROPN
biomedich-578	75	27	et	et	PROPN
biomedich-578	75	28	al	al	PROPN
biomedich-578	75	29	.	.	PROPN
biomedich-578	75	30	,	,	PUNCT
biomedich-578	75	31	2020	2020	NUM
biomedich-578	75	32	;	;	PUNCT
biomedich-578	75	33	reddy	reddy	PROPN
biomedich-578	75	34	et	et	PROPN
biomedich-578	75	35	al	al	PROPN
biomedich-578	75	36	.	.	PROPN
biomedich-578	75	37	,	,	PUNCT
biomedich-578	75	38	2023	2023	NUM
biomedich-578	75	39	)	)	PUNCT
biomedich-578	75	40	.	.	PUNCT
biomedich-578	76	1	therefore	therefore	ADV
biomedich-578	76	2	,	,	PUNCT
biomedich-578	76	3	preventing	prevent	VERB
biomedich-578	76	4	age	age	NOUN
biomedich-578	76	5	-	-	PUNCT
biomedich-578	76	6	rage	rage	NOUN
biomedich-578	76	7	interactions	interaction	NOUN
biomedich-578	76	8	with	with	ADP
biomedich-578	76	9	rage	rage	NOUN
biomedich-578	76	10	antagonists	antagonist	NOUN
biomedich-578	76	11	will	will	AUX
biomedich-578	76	12	attenuate	attenuate	VERB
biomedich-578	76	13	ad	ad	NOUN
biomedich-578	76	14	progression	progression	NOUN
biomedich-578	76	15	.	.	PUNCT
biomedich-578	77	1	oxidative	oxidative	ADJ
biomedich-578	77	2	stress	stress	NOUN
biomedich-578	77	3	an	an	DET
biomedich-578	77	4	abnormal	abnormal	ADJ
biomedich-578	77	5	increase	increase	NOUN
biomedich-578	77	6	in	in	ADP
biomedich-578	77	7	the	the	DET
biomedich-578	77	8	production	production	NOUN
biomedich-578	77	9	of	of	ADP
biomedich-578	77	10	ros	ros	PROPN
biomedich-578	77	11	leads	lead	VERB
biomedich-578	77	12	to	to	ADP
biomedich-578	77	13	oxidative	oxidative	ADJ
biomedich-578	77	14	stress	stress	NOUN
biomedich-578	77	15	,	,	PUNCT
biomedich-578	77	16	another	another	DET
biomedich-578	77	17	major	major	ADJ
biomedich-578	77	18	contributor	contributor	NOUN
biomedich-578	77	19	to	to	ADP
biomedich-578	77	20	the	the	DET
biomedich-578	77	21	development	development	NOUN
biomedich-578	77	22	of	of	ADP
biomedich-578	77	23	ad	ad	NOUN
biomedich-578	77	24	(	(	PUNCT
biomedich-578	77	25	martins	martin	NOUN
biomedich-578	77	26	et	et	NOUN
biomedich-578	77	27	al	al	PROPN
biomedich-578	77	28	.	.	PROPN
biomedich-578	77	29	,	,	PUNCT
biomedich-578	77	30	2020	2020	NUM
biomedich-578	77	31	)	)	PUNCT
biomedich-578	77	32	.	.	PUNCT
biomedich-578	78	1	in	in	ADP
biomedich-578	78	2	addition	addition	NOUN
biomedich-578	78	3	to	to	ADP
biomedich-578	78	4	binding	bind	VERB
biomedich-578	78	5	with	with	ADP
biomedich-578	78	6	age	age	NOUN
biomedich-578	78	7	,	,	PUNCT
biomedich-578	78	8	rage	rage	NOUN
biomedich-578	78	9	can	can	AUX
biomedich-578	78	10	also	also	ADV
biomedich-578	78	11	bind	bind	VERB
biomedich-578	78	12	to	to	ADP
biomedich-578	78	13	aβ	aβ	NUM
biomedich-578	78	14	,	,	PUNCT
biomedich-578	78	15	forming	form	VERB
biomedich-578	78	16	436	436	NUM
biomedich-578	78	17	biology	biology	NOUN
biomedich-578	78	18	,	,	PUNCT
biomedich-578	78	19	medicine	medicine	NOUN
biomedich-578	78	20	,	,	PUNCT
biomedich-578	78	21	&	&	CCONJ
biomedich-578	78	22	natural	natural	ADJ
biomedich-578	78	23	product	product	NOUN
biomedich-578	78	24	chemistry	chemistry	NOUN
biomedich-578	78	25	13	13	NUM
biomedich-578	78	26	(	(	PUNCT
biomedich-578	78	27	2	2	NUM
biomedich-578	78	28	)	)	PUNCT
biomedich-578	78	29	,	,	PUNCT
biomedich-578	78	30	2024	2024	NUM
biomedich-578	78	31	:	:	PUNCT
biomedich-578	78	32	433	433	NUM
biomedich-578	78	33	-	-	SYM
biomedich-578	78	34	441	441	NUM
biomedich-578	78	35	ros	ro	NOUN
biomedich-578	78	36	and	and	CCONJ
biomedich-578	78	37	increasing	increase	VERB
biomedich-578	78	38	the	the	DET
biomedich-578	78	39	secretion	secretion	NOUN
biomedich-578	78	40	of	of	ADP
biomedich-578	78	41	nitric	nitric	ADJ
biomedich-578	78	42	oxide	oxide	NOUN
biomedich-578	78	43	synthase	synthase	NOUN
biomedich-578	78	44	(	(	PUNCT
biomedich-578	78	45	nos	nos	NOUN
biomedich-578	78	46	)	)	PUNCT
biomedich-578	78	47	,	,	PUNCT
biomedich-578	78	48	thereby	thereby	ADV
biomedich-578	78	49	enhancing	enhance	VERB
biomedich-578	78	50	the	the	DET
biomedich-578	78	51	deposition	deposition	NOUN
biomedich-578	78	52	of	of	ADP
biomedich-578	78	53	aβ	aβ	PRON
biomedich-578	78	54	in	in	ADP
biomedich-578	78	55	the	the	DET
biomedich-578	78	56	brain	brain	NOUN
biomedich-578	78	57	(	(	PUNCT
biomedich-578	78	58	kong	kong	PROPN
biomedich-578	78	59	et	et	PROPN
biomedich-578	78	60	al	al	PROPN
biomedich-578	78	61	.	.	PROPN
biomedich-578	78	62	,	,	PUNCT
biomedich-578	78	63	2020	2020	NUM
biomedich-578	78	64	)	)	PUNCT
biomedich-578	78	65	.	.	PUNCT
biomedich-578	79	1	increased	increase	VERB
biomedich-578	79	2	ros	ros	PROPN
biomedich-578	79	3	production	production	NOUN
biomedich-578	79	4	causes	cause	VERB
biomedich-578	79	5	the	the	DET
biomedich-578	79	6	translocation	translocation	NOUN
biomedich-578	79	7	of	of	ADP
biomedich-578	79	8	nrf2	nrf2	NOUN
biomedich-578	79	9	from	from	ADP
biomedich-578	79	10	the	the	DET
biomedich-578	79	11	cytoplasm	cytoplasm	NOUN
biomedich-578	79	12	to	to	ADP
biomedich-578	79	13	the	the	DET
biomedich-578	79	14	nucleus	nucleus	NOUN
biomedich-578	79	15	.	.	PUNCT
biomedich-578	80	1	this	this	DET
biomedich-578	80	2	translocation	translocation	NOUN
biomedich-578	80	3	activates	activate	VERB
biomedich-578	80	4	the	the	DET
biomedich-578	80	5	transcription	transcription	NOUN
biomedich-578	80	6	of	of	ADP
biomedich-578	80	7	genes	gene	NOUN
biomedich-578	80	8	that	that	PRON
biomedich-578	80	9	lead	lead	VERB
biomedich-578	80	10	to	to	ADP
biomedich-578	80	11	antioxidant	antioxidant	ADJ
biomedich-578	80	12	responses	response	NOUN
biomedich-578	80	13	.	.	PUNCT
biomedich-578	81	1	nrf2	nrf2	NOUN
biomedich-578	81	2	activation	activation	NOUN
biomedich-578	81	3	also	also	ADV
biomedich-578	81	4	leads	lead	VERB
biomedich-578	81	5	to	to	ADP
biomedich-578	81	6	increased	increase	VERB
biomedich-578	81	7	autophagy	autophagy	NOUN
biomedich-578	81	8	,	,	PUNCT
biomedich-578	81	9	which	which	PRON
biomedich-578	81	10	enhances	enhance	VERB
biomedich-578	81	11	the	the	DET
biomedich-578	81	12	clearance	clearance	NOUN
biomedich-578	81	13	of	of	ADP
biomedich-578	81	14	app	app	NOUN
biomedich-578	81	15	and	and	CCONJ
biomedich-578	81	16	tau	tau	PROPN
biomedich-578	81	17	.	.	PUNCT
biomedich-578	82	1	nrf2	nrf2	PROPN
biomedich-578	82	2	activators	activator	NOUN
biomedich-578	82	3	can	can	AUX
biomedich-578	82	4	suppress	suppress	VERB
biomedich-578	82	5	nf	nf	ADJ
biomedich-578	82	6	-	-	PUNCT
biomedich-578	82	7	κb	κb	NOUN
biomedich-578	82	8	activity	activity	NOUN
biomedich-578	82	9	,	,	PUNCT
biomedich-578	82	10	thus	thus	ADV
biomedich-578	82	11	also	also	ADV
biomedich-578	82	12	affecting	affect	VERB
biomedich-578	82	13	the	the	DET
biomedich-578	82	14	inflammatory	inflammatory	ADJ
biomedich-578	82	15	cascade	cascade	NOUN
biomedich-578	82	16	.	.	PUNCT
biomedich-578	83	1	high	high	ADJ
biomedich-578	83	2	levels	level	NOUN
biomedich-578	83	3	of	of	ADP
biomedich-578	83	4	nrf2	nrf2	PROPN
biomedich-578	83	5	can	can	AUX
biomedich-578	83	6	ameliorate	ameliorate	VERB
biomedich-578	83	7	oxidative	oxidative	ADJ
biomedich-578	83	8	stress	stress	NOUN
biomedich-578	83	9	damage	damage	NOUN
biomedich-578	83	10	(	(	PUNCT
biomedich-578	83	11	osama	osama	PROPN
biomedich-578	83	12	et	et	PROPN
biomedich-578	83	13	al	al	PROPN
biomedich-578	83	14	.	.	PROPN
biomedich-578	83	15	,	,	PUNCT
biomedich-578	83	16	2020	2020	NUM
biomedich-578	83	17	;	;	PUNCT
biomedich-578	83	18	plano	plano	PROPN
biomedich-578	83	19	et	et	PROPN
biomedich-578	83	20	al	al	PROPN
biomedich-578	83	21	.	.	PROPN
biomedich-578	83	22	,	,	PUNCT
biomedich-578	83	23	2023	2023	NUM
biomedich-578	83	24	)	)	PUNCT
biomedich-578	83	25	.	.	PUNCT
biomedich-578	84	1	on	on	ADP
biomedich-578	84	2	the	the	DET
biomedich-578	84	3	other	other	ADJ
biomedich-578	84	4	hand	hand	NOUN
biomedich-578	84	5	,	,	PUNCT
biomedich-578	84	6	high	high	ADJ
biomedich-578	84	7	levels	level	NOUN
biomedich-578	84	8	of	of	ADP
biomedich-578	84	9	aβ	aβ	PRON
biomedich-578	84	10	and	and	CCONJ
biomedich-578	84	11	tau	tau	PROPN
biomedich-578	84	12	can	can	AUX
biomedich-578	84	13	be	be	AUX
biomedich-578	84	14	the	the	DET
biomedich-578	84	15	cause	cause	NOUN
biomedich-578	84	16	of	of	ADP
biomedich-578	84	17	oxidative	oxidative	ADJ
biomedich-578	84	18	stress	stress	NOUN
biomedich-578	84	19	.	.	PUNCT
biomedich-578	85	1	current	current	ADJ
biomedich-578	85	2	pharmacological	pharmacological	NOUN
biomedich-578	85	3	intervention	intervention	NOUN
biomedich-578	85	4	ad	ad	NOUN
biomedich-578	85	5	therapies	therapy	NOUN
biomedich-578	85	6	that	that	PRON
biomedich-578	85	7	have	have	AUX
biomedich-578	85	8	been	be	AUX
biomedich-578	85	9	used	use	VERB
biomedich-578	85	10	and	and	CCONJ
biomedich-578	85	11	approved	approve	VERB
biomedich-578	85	12	by	by	ADP
biomedich-578	85	13	the	the	DET
biomedich-578	85	14	fda	fda	PROPN
biomedich-578	85	15	are	be	AUX
biomedich-578	85	16	therapies	therapy	NOUN
biomedich-578	85	17	that	that	PRON
biomedich-578	85	18	only	only	ADV
biomedich-578	85	19	relieve	relieve	VERB
biomedich-578	85	20	the	the	DET
biomedich-578	85	21	symptoms	symptom	NOUN
biomedich-578	85	22	of	of	ADP
biomedich-578	85	23	ad	ad	NOUN
biomedich-578	85	24	,	,	PUNCT
biomedich-578	85	25	such	such	ADJ
biomedich-578	85	26	as	as	ADP
biomedich-578	85	27	acetylcholinesterase	acetylcholinesterase	NOUN
biomedich-578	85	28	inhibitors	inhibitor	NOUN
biomedich-578	85	29	(	(	PUNCT
biomedich-578	85	30	acheis	acheis	NOUN
biomedich-578	85	31	)	)	PUNCT
biomedich-578	85	32	and	and	CCONJ
biomedich-578	85	33	nmethyl	nmethyl	PROPN
biomedich-578	85	34	-	-	PUNCT
biomedich-578	85	35	d	d	NOUN
biomedich-578	85	36	-	-	PUNCT
biomedich-578	85	37	aspartate	aspartate	ADJ
biomedich-578	85	38	(	(	PUNCT
biomedich-578	85	39	nmda	nmda	ADJ
biomedich-578	85	40	)	)	PUNCT
biomedich-578	85	41	receptor	receptor	NOUN
biomedich-578	85	42	antagonists	antagonist	NOUN
biomedich-578	85	43	.	.	PUNCT
biomedich-578	86	1	acheis	acheis	NOUN
biomedich-578	86	2	(	(	PUNCT
biomedich-578	86	3	donepezil	donepezil	NOUN
biomedich-578	86	4	,	,	PUNCT
biomedich-578	86	5	galantamine	galantamine	NOUN
biomedich-578	86	6	,	,	PUNCT
biomedich-578	86	7	and	and	CCONJ
biomedich-578	86	8	rivastigmine	rivastigmine	ADJ
biomedich-578	86	9	)	)	PUNCT
biomedich-578	86	10	cholinergic	cholinergic	ADJ
biomedich-578	86	11	dysfunction	dysfunction	NOUN
biomedich-578	86	12	occurs	occur	VERB
biomedich-578	86	13	in	in	ADP
biomedich-578	86	14	the	the	DET
biomedich-578	86	15	early	early	ADJ
biomedich-578	86	16	stages	stage	NOUN
biomedich-578	86	17	of	of	ADP
biomedich-578	86	18	ad	ad	NOUN
biomedich-578	86	19	,	,	PUNCT
biomedich-578	86	20	leading	lead	VERB
biomedich-578	86	21	to	to	ADP
biomedich-578	86	22	a	a	DET
biomedich-578	86	23	decrease	decrease	NOUN
biomedich-578	86	24	in	in	ADP
biomedich-578	86	25	the	the	DET
biomedich-578	86	26	levels	level	NOUN
biomedich-578	86	27	of	of	ADP
biomedich-578	86	28	various	various	ADJ
biomedich-578	86	29	neurotransmitters	neurotransmitter	NOUN
biomedich-578	86	30	such	such	ADJ
biomedich-578	86	31	as	as	ADP
biomedich-578	86	32	acetylcholine	acetylcholine	NOUN
biomedich-578	86	33	,	,	PUNCT
biomedich-578	86	34	serotonin	serotonin	NOUN
biomedich-578	86	35	,	,	PUNCT
biomedich-578	86	36	dopamine	dopamine	NOUN
biomedich-578	86	37	,	,	PUNCT
biomedich-578	86	38	norepinephrine	norepinephrine	NOUN
biomedich-578	86	39	,	,	PUNCT
biomedich-578	86	40	etc	etc	X
biomedich-578	86	41	.	.	X
biomedich-578	87	1	acetylcholine	acetylcholine	NOUN
biomedich-578	87	2	(	(	PUNCT
biomedich-578	87	3	ach	ach	NOUN
biomedich-578	87	4	)	)	PUNCT
biomedich-578	87	5	is	be	AUX
biomedich-578	87	6	an	an	DET
biomedich-578	87	7	important	important	ADJ
biomedich-578	87	8	neurotransmitter	neurotransmitter	NOUN
biomedich-578	87	9	that	that	PRON
biomedich-578	87	10	mediates	mediate	VERB
biomedich-578	87	11	communication	communication	NOUN
biomedich-578	87	12	between	between	ADP
biomedich-578	87	13	neurons	neuron	NOUN
biomedich-578	87	14	.	.	PUNCT
biomedich-578	88	1	decreased	decrease	VERB
biomedich-578	88	2	levels	level	NOUN
biomedich-578	88	3	and	and	CCONJ
biomedich-578	88	4	availability	availability	NOUN
biomedich-578	88	5	of	of	ADP
biomedich-578	88	6	ach	ach	PROPN
biomedich-578	88	7	can	can	AUX
biomedich-578	88	8	directly	directly	ADV
biomedich-578	88	9	lead	lead	VERB
biomedich-578	88	10	to	to	ADP
biomedich-578	88	11	cell	cell	NOUN
biomedich-578	88	12	damage	damage	NOUN
biomedich-578	88	13	,	,	PUNCT
biomedich-578	88	14	thereby	thereby	ADV
biomedich-578	88	15	reducing	reduce	VERB
biomedich-578	88	16	the	the	DET
biomedich-578	88	17	level	level	NOUN
biomedich-578	88	18	of	of	ADP
biomedich-578	88	19	serotonin	serotonin	NOUN
biomedich-578	88	20	and	and	CCONJ
biomedich-578	88	21	intensifying	intensify	VERB
biomedich-578	88	22	the	the	DET
biomedich-578	88	23	development	development	NOUN
biomedich-578	88	24	of	of	ADP
biomedich-578	88	25	nfts	nft	NOUN
biomedich-578	88	26	.	.	PUNCT
biomedich-578	89	1	the	the	DET
biomedich-578	89	2	decrease	decrease	NOUN
biomedich-578	89	3	in	in	ADP
biomedich-578	89	4	ach	ach	PROPN
biomedich-578	89	5	levels	level	NOUN
biomedich-578	89	6	is	be	AUX
biomedich-578	89	7	influenced	influence	VERB
biomedich-578	89	8	by	by	ADP
biomedich-578	89	9	the	the	DET
biomedich-578	89	10	following	following	ADJ
biomedich-578	89	11	enzymes	enzyme	NOUN
biomedich-578	89	12	:	:	PUNCT
biomedich-578	89	13	acetylcholinesterase	acetylcholinesterase	NOUN
biomedich-578	89	14	(	(	PUNCT
biomedich-578	89	15	ache	ache	ADV
biomedich-578	89	16	)	)	PUNCT
biomedich-578	89	17	,	,	PUNCT
biomedich-578	89	18	which	which	PRON
biomedich-578	89	19	plays	play	VERB
biomedich-578	89	20	a	a	DET
biomedich-578	89	21	role	role	NOUN
biomedich-578	89	22	in	in	ADP
biomedich-578	89	23	breaking	break	VERB
biomedich-578	89	24	down	down	ADP
biomedich-578	89	25	acetylcholine	acetylcholine	NOUN
biomedich-578	89	26	,	,	PUNCT
biomedich-578	89	27	and	and	CCONJ
biomedich-578	89	28	butyrylcholinesterase	butyrylcholinesterase	NOUN
biomedich-578	89	29	(	(	PUNCT
biomedich-578	89	30	bche	bche	NOUN
biomedich-578	89	31	)	)	PUNCT
biomedich-578	89	32	,	,	PUNCT
biomedich-578	89	33	which	which	PRON
biomedich-578	89	34	is	be	AUX
biomedich-578	89	35	responsible	responsible	ADJ
biomedich-578	89	36	for	for	ADP
biomedich-578	89	37	the	the	DET
biomedich-578	89	38	degradation	degradation	NOUN
biomedich-578	89	39	of	of	ADP
biomedich-578	89	40	acetylcholine	acetylcholine	NOUN
biomedich-578	89	41	(	(	PUNCT
biomedich-578	89	42	metha	metha	NOUN
biomedich-578	89	43	et	et	PROPN
biomedich-578	89	44	al	al	PROPN
biomedich-578	89	45	.	.	PROPN
biomedich-578	89	46	,	,	PUNCT
biomedich-578	89	47	2017	2017	NUM
biomedich-578	89	48	)	)	PUNCT
biomedich-578	89	49	.	.	PUNCT
biomedich-578	90	1	inhibition	inhibition	NOUN
biomedich-578	90	2	of	of	ADP
biomedich-578	90	3	ache	ache	NOUN
biomedich-578	90	4	and	and	CCONJ
biomedich-578	90	5	bche	bche	NOUN
biomedich-578	90	6	is	be	AUX
biomedich-578	90	7	associated	associate	VERB
biomedich-578	90	8	with	with	ADP
biomedich-578	90	9	delaying	delay	VERB
biomedich-578	90	10	the	the	DET
biomedich-578	90	11	cognitive	cognitive	ADJ
biomedich-578	90	12	decline	decline	NOUN
biomedich-578	90	13	in	in	ADP
biomedich-578	90	14	ad	ad	NOUN
biomedich-578	90	15	patients	patient	NOUN
biomedich-578	90	16	.	.	PUNCT
biomedich-578	91	1	ache	ache	PROPN
biomedich-578	91	2	inhibitors	inhibitor	NOUN
biomedich-578	91	3	(	(	PUNCT
biomedich-578	91	4	acheis	acheis	NOUN
biomedich-578	91	5	)	)	PUNCT
biomedich-578	91	6	such	such	ADJ
biomedich-578	91	7	as	as	ADP
biomedich-578	91	8	donepezil	donepezil	NOUN
biomedich-578	91	9	and	and	CCONJ
biomedich-578	91	10	galantamine	galantamine	NOUN
biomedich-578	91	11	,	,	PUNCT
biomedich-578	91	12	as	as	ADV
biomedich-578	91	13	well	well	ADV
biomedich-578	91	14	as	as	ADP
biomedich-578	91	15	pseudoirreversible	pseudoirreversible	ADJ
biomedich-578	91	16	achei	achei	NOUN
biomedich-578	91	17	and	and	CCONJ
biomedich-578	91	18	bche	bche	NOUN
biomedich-578	91	19	inhibitors	inhibitor	NOUN
biomedich-578	91	20	(	(	PUNCT
biomedich-578	91	21	bcheis	bcheis	NOUN
biomedich-578	91	22	)	)	PUNCT
biomedich-578	91	23	like	like	ADP
biomedich-578	91	24	rivastigmine	rivastigmine	NOUN
biomedich-578	91	25	are	be	AUX
biomedich-578	91	26	symptomatic	symptomatic	ADJ
biomedich-578	91	27	therapy	therapy	NOUN
biomedich-578	91	28	approved	approve	VERB
biomedich-578	91	29	and	and	CCONJ
biomedich-578	91	30	still	still	ADV
biomedich-578	91	31	in	in	ADP
biomedich-578	91	32	use	use	NOUN
biomedich-578	91	33	to	to	ADP
biomedich-578	91	34	date	date	NOUN
biomedich-578	91	35	for	for	ADP
biomedich-578	91	36	ad	ad	NOUN
biomedich-578	91	37	.	.	PUNCT
biomedich-578	92	1	nevertheless	nevertheless	ADV
biomedich-578	92	2	,	,	PUNCT
biomedich-578	92	3	these	these	DET
biomedich-578	92	4	drugs	drug	NOUN
biomedich-578	92	5	are	be	AUX
biomedich-578	92	6	believed	believe	VERB
biomedich-578	92	7	to	to	PART
biomedich-578	92	8	only	only	ADV
biomedich-578	92	9	improve	improve	VERB
biomedich-578	92	10	the	the	DET
biomedich-578	92	11	symptoms	symptom	NOUN
biomedich-578	92	12	of	of	ADP
biomedich-578	92	13	ad	ad	NOUN
biomedich-578	92	14	without	without	ADP
biomedich-578	92	15	restoring	restore	VERB
biomedich-578	92	16	it	it	PRON
biomedich-578	92	17	to	to	ADP
biomedich-578	92	18	its	its	PRON
biomedich-578	92	19	original	original	ADJ
biomedich-578	92	20	state	state	NOUN
biomedich-578	92	21	(	(	PUNCT
biomedich-578	92	22	yiannopoulou	yiannopoulou	NOUN
biomedich-578	92	23	et	et	PROPN
biomedich-578	92	24	al	al	PROPN
biomedich-578	92	25	.	.	PROPN
biomedich-578	92	26	,	,	PUNCT
biomedich-578	92	27	2019	2019	NUM
biomedich-578	92	28	)	)	PUNCT
biomedich-578	92	29	.	.	PUNCT
biomedich-578	93	1	nmda	nmda	ADJ
biomedich-578	93	2	receptor	receptor	NOUN
biomedich-578	93	3	antagonist	antagonist	NOUN
biomedich-578	93	4	(	(	PUNCT
biomedich-578	93	5	memantine	memantine	NOUN
biomedich-578	93	6	)	)	PUNCT
biomedich-578	93	7	insufficient	insufficient	ADJ
biomedich-578	93	8	synaptic	synaptic	ADJ
biomedich-578	93	9	nmdar	nmdar	NOUN
biomedich-578	93	10	signalling	signal	VERB
biomedich-578	93	11	compromises	compromise	NOUN
biomedich-578	93	12	neuronal	neuronal	ADJ
biomedich-578	93	13	cell	cell	NOUN
biomedich-578	93	14	survival	survival	NOUN
biomedich-578	93	15	,	,	PUNCT
biomedich-578	93	16	but	but	CCONJ
biomedich-578	93	17	excessive	excessive	ADJ
biomedich-578	93	18	stimulation	stimulation	NOUN
biomedich-578	93	19	of	of	ADP
biomedich-578	93	20	glutamatergic	glutamatergic	ADJ
biomedich-578	93	21	signalling	signalling	NOUN
biomedich-578	93	22	leads	lead	NOUN
biomedich-578	93	23	to	to	ADP
biomedich-578	93	24	excitotoxicity	excitotoxicity	NOUN
biomedich-578	93	25	,	,	PUNCT
biomedich-578	93	26	resulting	result	VERB
biomedich-578	93	27	in	in	ADP
biomedich-578	93	28	damage	damage	NOUN
biomedich-578	93	29	and	and	CCONJ
biomedich-578	93	30	death	death	NOUN
biomedich-578	93	31	of	of	ADP
biomedich-578	93	32	neurons	neuron	NOUN
biomedich-578	93	33	.	.	PUNCT
biomedich-578	94	1	nmda	nmda	ADJ
biomedich-578	94	2	receptor	receptor	NOUN
biomedich-578	94	3	antagonists	antagonist	NOUN
biomedich-578	94	4	such	such	ADJ
biomedich-578	94	5	as	as	ADP
biomedich-578	94	6	memantine	memantine	NOUN
biomedich-578	94	7	are	be	AUX
biomedich-578	94	8	noncompetitive	noncompetitive	ADJ
biomedich-578	94	9	lowaffinity	lowaffinity	NOUN
biomedich-578	94	10	nmda	nmda	ADJ
biomedich-578	94	11	receptor	receptor	NOUN
biomedich-578	94	12	open	open	ADJ
biomedich-578	94	13	-	-	PUNCT
biomedich-578	94	14	channel	channel	NOUN
biomedich-578	94	15	blockers	blocker	NOUN
biomedich-578	94	16	that	that	PRON
biomedich-578	94	17	inhibit	inhibit	VERB
biomedich-578	94	18	glutamatergic	glutamatergic	ADJ
biomedich-578	94	19	transmissions	transmission	NOUN
biomedich-578	94	20	,	,	PUNCT
biomedich-578	94	21	leading	lead	VERB
biomedich-578	94	22	to	to	ADP
biomedich-578	94	23	decreased	decrease	VERB
biomedich-578	94	24	glutamate	glutamate	ADJ
biomedich-578	94	25	levels	level	NOUN
biomedich-578	94	26	and	and	CCONJ
biomedich-578	94	27	prevention	prevention	NOUN
biomedich-578	94	28	of	of	ADP
biomedich-578	94	29	neuronal	neuronal	ADJ
biomedich-578	94	30	dysfunction	dysfunction	NOUN
biomedich-578	94	31	(	(	PUNCT
biomedich-578	94	32	wang	wang	PROPN
biomedich-578	94	33	&	&	CCONJ
biomedich-578	94	34	reddy	reddy	PROPN
biomedich-578	94	35	,	,	PUNCT
biomedich-578	94	36	2017	2017	NUM
biomedich-578	94	37	)	)	PUNCT
biomedich-578	94	38	.	.	PUNCT
biomedich-578	95	1	marine	marine	PROPN
biomedich-578	95	2	natural	natural	ADJ
biomedich-578	95	3	products	product	NOUN
biomedich-578	95	4	(	(	PUNCT
biomedich-578	95	5	mnps	mnps	ADJ
biomedich-578	95	6	)	)	PUNCT
biomedich-578	95	7	prospect	prospect	NOUN
biomedich-578	95	8	for	for	ADP
biomedich-578	95	9	ad	ad	NOUN
biomedich-578	95	10	treatment	treatment	NOUN
biomedich-578	95	11	about	about	ADV
biomedich-578	95	12	70	70	NUM
biomedich-578	95	13	%	%	NOUN
biomedich-578	95	14	of	of	ADP
biomedich-578	95	15	the	the	DET
biomedich-578	95	16	earth	earth	NOUN
biomedich-578	95	17	's	's	PART
biomedich-578	95	18	surface	surface	NOUN
biomedich-578	95	19	is	be	AUX
biomedich-578	95	20	the	the	DET
biomedich-578	95	21	sea	sea	NOUN
biomedich-578	95	22	and	and	CCONJ
biomedich-578	95	23	half	half	NOUN
biomedich-578	95	24	of	of	ADP
biomedich-578	95	25	global	global	ADJ
biomedich-578	95	26	diversity	diversity	NOUN
biomedich-578	95	27	is	be	AUX
biomedich-578	95	28	found	find	VERB
biomedich-578	95	29	in	in	ADP
biomedich-578	95	30	marine	marine	ADJ
biomedich-578	95	31	ecosystems	ecosystem	NOUN
biomedich-578	95	32	(	(	PUNCT
biomedich-578	95	33	ferreira	ferreira	PROPN
biomedich-578	95	34	et	et	PROPN
biomedich-578	95	35	al	al	PROPN
biomedich-578	95	36	.	.	PROPN
biomedich-578	95	37	,	,	PUNCT
biomedich-578	95	38	2022	2022	NUM
biomedich-578	95	39	)	)	PUNCT
biomedich-578	95	40	.	.	PUNCT
biomedich-578	96	1	marine	marine	ADJ
biomedich-578	96	2	organisms	organism	NOUN
biomedich-578	96	3	,	,	PUNCT
biomedich-578	96	4	both	both	DET
biomedich-578	96	5	marine	marine	ADJ
biomedich-578	96	6	macroorganisms	macroorganism	NOUN
biomedich-578	96	7	(	(	PUNCT
biomedich-578	96	8	sponges	sponge	NOUN
biomedich-578	96	9	,	,	PUNCT
biomedich-578	96	10	ascidians	ascidian	NOUN
biomedich-578	96	11	/	/	SYM
biomedich-578	96	12	tunicates	tunicate	NOUN
biomedich-578	96	13	,	,	PUNCT
biomedich-578	96	14	echinoderms	echinoderm	NOUN
biomedich-578	96	15	,	,	PUNCT
biomedich-578	96	16	gorgonians	gorgonian	NOUN
biomedich-578	96	17	/	/	SYM
biomedich-578	96	18	octocorals	octocoral	NOUN
biomedich-578	96	19	,	,	PUNCT
biomedich-578	96	20	algae	algae	NOUN
biomedich-578	96	21	,	,	PUNCT
biomedich-578	96	22	mangroves	mangrove	NOUN
biomedich-578	96	23	)	)	PUNCT
biomedich-578	96	24	and	and	CCONJ
biomedich-578	96	25	marine	marine	ADJ
biomedich-578	96	26	microorganisms	microorganism	NOUN
biomedich-578	96	27	(	(	PUNCT
biomedich-578	96	28	marine	marine	ADJ
biomedich-578	96	29	fungi	fungus	NOUN
biomedich-578	96	30	and	and	CCONJ
biomedich-578	96	31	marine	marine	ADJ
biomedich-578	96	32	bacteria	bacteria	NOUN
biomedich-578	96	33	)	)	PUNCT
biomedich-578	96	34	are	be	AUX
biomedich-578	96	35	known	know	VERB
biomedich-578	96	36	to	to	PART
biomedich-578	96	37	possess	possess	VERB
biomedich-578	96	38	diverse	diverse	ADJ
biomedich-578	96	39	bioactive	bioactive	NOUN
biomedich-578	96	40	compounds	compound	NOUN
biomedich-578	96	41	with	with	ADP
biomedich-578	96	42	significant	significant	ADJ
biomedich-578	96	43	pharmacological	pharmacological	ADJ
biomedich-578	96	44	efficacy	efficacy	NOUN
biomedich-578	96	45	(	(	PUNCT
biomedich-578	96	46	bălașa	bălașa	NOUN
biomedich-578	96	47	et	et	PROPN
biomedich-578	96	48	al	al	PROPN
biomedich-578	96	49	.	.	PROPN
biomedich-578	96	50	,	,	PUNCT
biomedich-578	96	51	2020	2020	NUM
biomedich-578	96	52	;	;	PUNCT
biomedich-578	96	53	nugraha	nugraha	NOUN
biomedich-578	96	54	et	et	PROPN
biomedich-578	96	55	al	al	PROPN
biomedich-578	96	56	.	.	PROPN
biomedich-578	96	57	,	,	PUNCT
biomedich-578	96	58	2023	2023	NUM
biomedich-578	96	59	)	)	PUNCT
biomedich-578	96	60	.	.	PUNCT
biomedich-578	97	1	mnps	mnps	PROPN
biomedich-578	97	2	show	show	VERB
biomedich-578	97	3	10	10	NUM
biomedich-578	97	4	times	time	NOUN
biomedich-578	97	5	greater	great	ADJ
biomedich-578	97	6	biological	biological	ADJ
biomedich-578	97	7	activity	activity	NOUN
biomedich-578	97	8	than	than	ADP
biomedich-578	97	9	terrestrial	terrestrial	ADJ
biomedich-578	97	10	natural	natural	ADJ
biomedich-578	97	11	sources	source	NOUN
biomedich-578	97	12	,	,	PUNCT
biomedich-578	97	13	making	make	VERB
biomedich-578	97	14	them	they	PRON
biomedich-578	97	15	attractive	attractive	ADJ
biomedich-578	97	16	for	for	ADP
biomedich-578	97	17	continuous	continuous	ADJ
biomedich-578	97	18	exploration	exploration	NOUN
biomedich-578	97	19	(	(	PUNCT
biomedich-578	97	20	bălașa	bălașa	NOUN
biomedich-578	97	21	et	et	PROPN
biomedich-578	97	22	al	al	PROPN
biomedich-578	97	23	.	.	PROPN
biomedich-578	97	24	,	,	PUNCT
biomedich-578	97	25	2020	2020	NUM
biomedich-578	97	26	)	)	PUNCT
biomedich-578	97	27	.	.	PUNCT
biomedich-578	98	1	mnps	mnps	PROPN
biomedich-578	98	2	have	have	AUX
biomedich-578	98	3	been	be	AUX
biomedich-578	98	4	demonstrated	demonstrate	VERB
biomedich-578	98	5	to	to	PART
biomedich-578	98	6	be	be	AUX
biomedich-578	98	7	the	the	DET
biomedich-578	98	8	most	most	ADV
biomedich-578	98	9	prospective	prospective	ADJ
biomedich-578	98	10	candidates	candidate	NOUN
biomedich-578	98	11	for	for	ADP
biomedich-578	98	12	therapy	therapy	NOUN
biomedich-578	98	13	of	of	ADP
biomedich-578	98	14	various	various	ADJ
biomedich-578	98	15	diseases	disease	NOUN
biomedich-578	98	16	.	.	PUNCT
biomedich-578	99	1	the	the	DET
biomedich-578	99	2	first	first	ADJ
biomedich-578	99	3	marine	marine	ADJ
biomedich-578	99	4	-	-	PUNCT
biomedich-578	99	5	derived	derive	VERB
biomedich-578	99	6	drug	drug	NOUN
biomedich-578	99	7	to	to	PART
biomedich-578	99	8	receive	receive	VERB
biomedich-578	99	9	fda	fda	PROPN
biomedich-578	99	10	approval	approval	NOUN
biomedich-578	99	11	in	in	ADP
biomedich-578	99	12	1969	1969	NUM
biomedich-578	99	13	was	be	AUX
biomedich-578	99	14	an	an	DET
biomedich-578	99	15	anticancer	anticancer	NOUN
biomedich-578	99	16	therapy	therapy	NOUN
biomedich-578	99	17	cytarabine	cytarabine	NOUN
biomedich-578	99	18	from	from	ADP
biomedich-578	99	19	the	the	DET
biomedich-578	99	20	caribbean	caribbean	ADJ
biomedich-578	99	21	sponge	sponge	NOUN
biomedich-578	99	22	tethya	tethya	ADJ
biomedich-578	99	23	crypta	crypta	NOUN
biomedich-578	99	24	.	.	PUNCT
biomedich-578	100	1	subsequently	subsequently	ADV
biomedich-578	100	2	,	,	PUNCT
biomedich-578	100	3	vidarabine	vidarabine	NOUN
biomedich-578	100	4	(	(	PUNCT
biomedich-578	100	5	1976	1976	NUM
biomedich-578	100	6	)	)	PUNCT
biomedich-578	100	7	from	from	ADP
biomedich-578	100	8	the	the	DET
biomedich-578	100	9	same	same	ADJ
biomedich-578	100	10	source	source	NOUN
biomedich-578	100	11	was	be	AUX
biomedich-578	100	12	recognized	recognize	VERB
biomedich-578	100	13	for	for	ADP
biomedich-578	100	14	its	its	PRON
biomedich-578	100	15	antiviral	antiviral	ADJ
biomedich-578	100	16	effects	effect	NOUN
biomedich-578	100	17	.	.	PUNCT
biomedich-578	101	1	ziconotide	ziconotide	NOUN
biomedich-578	101	2	,	,	PUNCT
biomedich-578	101	3	a	a	DET
biomedich-578	101	4	synthetic	synthetic	ADJ
biomedich-578	101	5	compound	compound	NOUN
biomedich-578	101	6	similar	similar	ADJ
biomedich-578	101	7	to	to	ADP
biomedich-578	101	8	a	a	DET
biomedich-578	101	9	peptide	peptide	NOUN
biomedich-578	101	10	isolated	isolate	VERB
biomedich-578	101	11	from	from	ADP
biomedich-578	101	12	the	the	DET
biomedich-578	101	13	venom	venom	NOUN
biomedich-578	101	14	of	of	ADP
biomedich-578	101	15	the	the	DET
biomedich-578	101	16	cone	cone	NOUN
biomedich-578	101	17	snail	snail	NOUN
biomedich-578	101	18	conus	conus	NOUN
biomedich-578	101	19	magus	magus	NOUN
biomedich-578	101	20	,	,	PUNCT
biomedich-578	101	21	attained	attain	VERB
biomedich-578	101	22	fda	fda	PROPN
biomedich-578	101	23	approval	approval	NOUN
biomedich-578	101	24	in	in	ADP
biomedich-578	101	25	2004	2004	NUM
biomedich-578	101	26	for	for	ADP
biomedich-578	101	27	its	its	PRON
biomedich-578	101	28	potent	potent	ADJ
biomedich-578	101	29	analgesic	analgesic	ADJ
biomedich-578	101	30	effect	effect	NOUN
biomedich-578	101	31	.	.	PUNCT
biomedich-578	102	1	trabectedin	trabectedin	VERB
biomedich-578	102	2	from	from	ADP
biomedich-578	102	3	the	the	DET
biomedich-578	102	4	marine	marine	ADJ
biomedich-578	102	5	tunicate	tunicate	NOUN
biomedich-578	102	6	ecteinascidia	ecteinascidia	NOUN
biomedich-578	102	7	turbinate	turbinate	NOUN
biomedich-578	102	8	received	receive	VERB
biomedich-578	102	9	fda	fda	PROPN
biomedich-578	102	10	recognition	recognition	NOUN
biomedich-578	102	11	for	for	ADP
biomedich-578	102	12	second	second	ADJ
biomedich-578	102	13	-	-	PUNCT
biomedich-578	102	14	line	line	NOUN
biomedich-578	102	15	treatment	treatment	NOUN
biomedich-578	102	16	of	of	ADP
biomedich-578	102	17	liposarcoma	liposarcoma	NOUN
biomedich-578	102	18	or	or	CCONJ
biomedich-578	102	19	leiomyosarcoma	leiomyosarcoma	NOUN
biomedich-578	102	20	in	in	ADP
biomedich-578	102	21	2015	2015	NUM
biomedich-578	102	22	.	.	PUNCT
biomedich-578	103	1	in	in	ADP
biomedich-578	103	2	2016	2016	NUM
biomedich-578	103	3	,	,	PUNCT
biomedich-578	103	4	eribulin	eribulin	NOUN
biomedich-578	103	5	mesylate	mesylate	NOUN
biomedich-578	103	6	,	,	PUNCT
biomedich-578	103	7	a	a	DET
biomedich-578	103	8	synthetic	synthetic	ADJ
biomedich-578	103	9	analogue	analogue	NOUN
biomedich-578	103	10	of	of	ADP
biomedich-578	103	11	halichondrin	halichondrin	NOUN
biomedich-578	103	12	b	b	PROPN
biomedich-578	103	13	isolated	isolate	VERB
biomedich-578	103	14	from	from	ADP
biomedich-578	103	15	the	the	DET
biomedich-578	103	16	marine	marine	ADJ
biomedich-578	103	17	sponge	sponge	PROPN
biomedich-578	103	18	halichondria	halichondria	PROPN
biomedich-578	103	19	okadai	okadai	PROPN
biomedich-578	103	20	was	be	AUX
biomedich-578	103	21	approved	approve	VERB
biomedich-578	103	22	as	as	ADP
biomedich-578	103	23	a	a	DET
biomedich-578	103	24	chemotherapy	chemotherapy	NOUN
biomedich-578	103	25	agent	agent	NOUN
biomedich-578	103	26	(	(	PUNCT
biomedich-578	103	27	montaser	montaser	PROPN
biomedich-578	103	28	&	&	CCONJ
biomedich-578	103	29	luesch	luesch	PROPN
biomedich-578	103	30	,	,	PUNCT
biomedich-578	103	31	2011	2011	NUM
biomedich-578	103	32	;	;	PUNCT
biomedich-578	103	33	altmann	altmann	NOUN
biomedich-578	103	34	,	,	PUNCT
biomedich-578	103	35	2017	2017	NUM
biomedich-578	103	36	)	)	PUNCT
biomedich-578	103	37	.	.	PUNCT
biomedich-578	104	1	limitless	limitless	ADJ
biomedich-578	104	2	discoveries	discovery	NOUN
biomedich-578	104	3	continue	continue	VERB
biomedich-578	104	4	,	,	PUNCT
biomedich-578	104	5	with	with	ADP
biomedich-578	104	6	ongoing	ongoing	ADJ
biomedich-578	104	7	exploration	exploration	NOUN
biomedich-578	104	8	of	of	ADP
biomedich-578	104	9	mnps	mnps	PROPN
biomedich-578	104	10	to	to	PART
biomedich-578	104	11	produce	produce	VERB
biomedich-578	104	12	novel	novel	ADJ
biomedich-578	104	13	therapies	therapy	NOUN
biomedich-578	104	14	for	for	ADP
biomedich-578	104	15	multifarious	multifarious	ADJ
biomedich-578	104	16	diseases	disease	NOUN
biomedich-578	104	17	(	(	PUNCT
biomedich-578	104	18	altmann	altmann	NOUN
biomedich-578	104	19	,	,	PUNCT
biomedich-578	104	20	2017	2017	NUM
biomedich-578	104	21	)	)	PUNCT
biomedich-578	104	22	.	.	PUNCT
biomedich-578	105	1	despite	despite	SCONJ
biomedich-578	105	2	the	the	DET
biomedich-578	105	3	many	many	ADJ
biomedich-578	105	4	studies	study	NOUN
biomedich-578	105	5	showing	show	VERB
biomedich-578	105	6	the	the	DET
biomedich-578	105	7	potential	potential	NOUN
biomedich-578	105	8	of	of	ADP
biomedich-578	105	9	mnps	mnps	PROPN
biomedich-578	105	10	for	for	ADP
biomedich-578	105	11	ad	ad	NOUN
biomedich-578	105	12	therapy	therapy	NOUN
biomedich-578	105	13	,	,	PUNCT
biomedich-578	105	14	development	development	NOUN
biomedich-578	105	15	studies	study	NOUN
biomedich-578	105	16	of	of	ADP
biomedich-578	105	17	mnps	mnps	PROPN
biomedich-578	105	18	for	for	ADP
biomedich-578	105	19	dmts	dmts	NOUN
biomedich-578	105	20	in	in	ADP
biomedich-578	105	21	ad	ad	NOUN
biomedich-578	105	22	are	be	AUX
biomedich-578	105	23	still	still	ADV
biomedich-578	105	24	limited	limit	VERB
biomedich-578	105	25	to	to	ADP
biomedich-578	105	26	the	the	DET
biomedich-578	105	27	first	first	ADJ
biomedich-578	105	28	stage	stage	NOUN
biomedich-578	105	29	of	of	ADP
biomedich-578	105	30	the	the	DET
biomedich-578	105	31	fda	fda	PROPN
biomedich-578	105	32	drug	drug	PROPN
biomedich-578	105	33	development	development	NOUN
biomedich-578	105	34	process	process	NOUN
biomedich-578	105	35	.	.	PUNCT
biomedich-578	106	1	therefore	therefore	ADV
biomedich-578	106	2	,	,	PUNCT
biomedich-578	106	3	this	this	PRON
biomedich-578	106	4	remains	remain	VERB
biomedich-578	106	5	a	a	DET
biomedich-578	106	6	challenge	challenge	NOUN
biomedich-578	106	7	and	and	CCONJ
biomedich-578	106	8	a	a	DET
biomedich-578	106	9	fertile	fertile	ADJ
biomedich-578	106	10	ground	ground	NOUN
biomedich-578	106	11	for	for	ADP
biomedich-578	106	12	further	further	ADJ
biomedich-578	106	13	studies	study	NOUN
biomedich-578	106	14	in	in	ADP
biomedich-578	106	15	discovering	discover	VERB
biomedich-578	106	16	new	new	ADJ
biomedich-578	106	17	drugs	drug	NOUN
biomedich-578	106	18	.	.	PUNCT
biomedich-578	107	1	table	table	NOUN
biomedich-578	107	2	1	1	NUM
biomedich-578	107	3	shows	show	VERB
biomedich-578	107	4	the	the	DET
biomedich-578	107	5	group	group	NOUN
biomedich-578	107	6	of	of	ADP
biomedich-578	107	7	mnps	mnps	PROPN
biomedich-578	107	8	with	with	ADP
biomedich-578	107	9	multiple	multiple	ADJ
biomedich-578	107	10	potential	potential	ADJ
biomedich-578	107	11	targets	target	NOUN
biomedich-578	107	12	in	in	ADP
biomedich-578	107	13	ad	ad	NOUN
biomedich-578	107	14	treatment	treatment	NOUN
biomedich-578	107	15	.	.	PUNCT
biomedich-578	108	1	marine	marine	PROPN
biomedich-578	108	2	vertebrae	vertebrae	NOUN
biomedich-578	108	3	every	every	DET
biomedich-578	108	4	type	type	NOUN
biomedich-578	108	5	of	of	ADP
biomedich-578	108	6	fish	fish	NOUN
biomedich-578	108	7	is	be	AUX
biomedich-578	108	8	a	a	DET
biomedich-578	108	9	rich	rich	ADJ
biomedich-578	108	10	source	source	NOUN
biomedich-578	108	11	of	of	ADP
biomedich-578	108	12	n−3	n−3	PROPN
biomedich-578	108	13	polyunsaturated	polyunsaturated	ADJ
biomedich-578	108	14	fatty	fatty	NOUN
biomedich-578	108	15	acids	acid	NOUN
biomedich-578	108	16	(	(	PUNCT
biomedich-578	108	17	pufas	pufas	NOUN
biomedich-578	108	18	)	)	PUNCT
biomedich-578	108	19	,	,	PUNCT
biomedich-578	108	20	especially	especially	ADV
biomedich-578	108	21	docosahexaenoic	docosahexaenoic	ADJ
biomedich-578	108	22	acid	acid	NOUN
biomedich-578	108	23	(	(	PUNCT
biomedich-578	108	24	dha	dha	PROPN
biomedich-578	108	25	)	)	PUNCT
biomedich-578	108	26	(	(	PUNCT
biomedich-578	108	27	ferreira	ferreira	PROPN
biomedich-578	108	28	et	et	PROPN
biomedich-578	108	29	al	al	PROPN
biomedich-578	108	30	.	.	PROPN
biomedich-578	108	31	,	,	PUNCT
biomedich-578	108	32	2022	2022	NUM
biomedich-578	108	33	)	)	PUNCT
biomedich-578	108	34	.	.	PUNCT
biomedich-578	109	1	marine	marine	PROPN
biomedich-578	109	2	fishes	fish	NOUN
biomedich-578	109	3	such	such	ADJ
biomedich-578	109	4	as	as	ADP
biomedich-578	109	5	blackmouth	blackmouth	PROPN
biomedich-578	109	6	catshark	catshark	NOUN
biomedich-578	109	7	(	(	PUNCT
biomedich-578	109	8	galeus	galeus	NOUN
biomedich-578	109	9	melastomus	melastomus	NOUN
biomedich-578	109	10	)	)	PUNCT
biomedich-578	109	11	and	and	CCONJ
biomedich-578	109	12	the	the	DET
biomedich-578	109	13	brown	brown	ADJ
biomedich-578	109	14	meagre/	meagre/	PROPN
biomedich-578	109	15	corb	corb	NOUN
biomedich-578	109	16	(	(	PUNCT
biomedich-578	109	17	sciaena	sciaena	PROPN
biomedich-578	109	18	umbra	umbra	NOUN
biomedich-578	109	19	)	)	PUNCT
biomedich-578	109	20	contain	contain	VERB
biomedich-578	109	21	marine	marine	ADJ
biomedich-578	109	22	-	-	PUNCT
biomedich-578	109	23	derived	derive	VERB
biomedich-578	109	24	glycosaminoglycans	glycosaminoglycan	NOUN
biomedich-578	109	25	,	,	PUNCT
biomedich-578	109	26	namely	namely	ADV
biomedich-578	109	27	chondroitin	chondroitin	NOUN
biomedich-578	109	28	sulfate	sulfate	NOUN
biomedich-578	109	29	.	.	PUNCT
biomedich-578	110	1	chondroitin	chondroitin	NOUN
biomedich-578	110	2	sulfate	sulfate	NOUN
biomedich-578	110	3	can	can	AUX
biomedich-578	110	4	combat	combat	VERB
biomedich-578	110	5	toxicity	toxicity	NOUN
biomedich-578	110	6	caused	cause	VERB
biomedich-578	110	7	by	by	ADP
biomedich-578	110	8	ages	age	NOUN
biomedich-578	110	9	,	,	PUNCT
biomedich-578	110	10	which	which	PRON
biomedich-578	110	11	impact	impact	VERB
biomedich-578	110	12	aβ	aβ	DET
biomedich-578	110	13	aggregation	aggregation	NOUN
biomedich-578	110	14	,	,	PUNCT
biomedich-578	110	15	oxidative	oxidative	ADJ
biomedich-578	110	16	stress	stress	NOUN
biomedich-578	110	17	,	,	PUNCT
biomedich-578	110	18	and	and	CCONJ
biomedich-578	110	19	neuroinflammation	neuroinflammation	NOUN
biomedich-578	110	20	(	(	PUNCT
biomedich-578	110	21	iannuzzi	iannuzzi	NOUN
biomedich-578	110	22	et	et	PROPN
biomedich-578	110	23	al	al	PROPN
biomedich-578	110	24	.	.	PROPN
biomedich-578	110	25	,	,	PUNCT
biomedich-578	110	26	2019	2019	NUM
biomedich-578	110	27	;	;	PUNCT
biomedich-578	110	28	bălașa	bălașa	VERB
biomedich-578	110	29	et	et	PROPN
biomedich-578	110	30	al	al	PROPN
biomedich-578	110	31	.	.	PROPN
biomedich-578	110	32	,	,	PUNCT
biomedich-578	110	33	2020	2020	NUM
biomedich-578	110	34	)	)	PUNCT
biomedich-578	110	35	.	.	PUNCT
biomedich-578	111	1	the	the	DET
biomedich-578	111	2	liver	liver	NOUN
biomedich-578	111	3	oil	oil	NOUN
biomedich-578	111	4	of	of	ADP
biomedich-578	111	5	cod	cod	NOUN
biomedich-578	111	6	fish	fish	NOUN
biomedich-578	111	7	especially	especially	ADV
biomedich-578	111	8	gadus	gadus	PROPN
biomedich-578	111	9	morrhua	morrhua	PROPN
biomedich-578	111	10	l.	l.	PROPN
biomedich-578	111	11	consists	consist	VERB
biomedich-578	111	12	of	of	ADP
biomedich-578	111	13	polyunsaturated	polyunsaturated	ADJ
biomedich-578	111	14	fatty	fatty	NOUN
biomedich-578	111	15	acids	acid	NOUN
biomedich-578	111	16	,	,	PUNCT
biomedich-578	111	17	especially	especially	ADV
biomedich-578	111	18	ω-3	ω-3	NUM
biomedich-578	111	19	fatty	fatty	NOUN
biomedich-578	111	20	acids	acid	NOUN
biomedich-578	111	21	,	,	PUNCT
biomedich-578	111	22	which	which	PRON
biomedich-578	111	23	have	have	VERB
biomedich-578	111	24	benefits	benefit	NOUN
biomedich-578	111	25	in	in	ADP
biomedich-578	111	26	setiawan	setiawan	PROPN
biomedich-578	111	27	et	et	PROPN
biomedich-578	111	28	al	al	PROPN
biomedich-578	111	29	.	.	PROPN
biomedich-578	112	1	–	–	PUNCT
biomedich-578	112	2	physicochemical	physicochemical	ADJ
biomedich-578	112	3	candy	candy	NOUN
biomedich-578	112	4	cinnamon	cinnamon	NOUN
biomedich-578	112	5	seaweed	seaweed	NOUN
biomedich-578	112	6	carrageenan	carrageenan	NOUN
biomedich-578	112	7	.	.	PUNCT
biomedich-578	113	1	437	437	NUM
biomedich-578	113	2	reducing	reduce	VERB
biomedich-578	113	3	aβ	aβ	NOUN
biomedich-578	113	4	toxicity	toxicity	NOUN
biomedich-578	113	5	through	through	ADP
biomedich-578	113	6	increased	increase	VERB
biomedich-578	113	7	degradation	degradation	NOUN
biomedich-578	113	8	and	and	CCONJ
biomedich-578	113	9	clearance	clearance	NOUN
biomedich-578	113	10	(	(	PUNCT
biomedich-578	113	11	bălașa	bălașa	NOUN
biomedich-578	113	12	et	et	PROPN
biomedich-578	113	13	al	al	PROPN
biomedich-578	113	14	.	.	PROPN
biomedich-578	113	15	,	,	PUNCT
biomedich-578	113	16	2020	2020	NUM
biomedich-578	113	17	)	)	PUNCT
biomedich-578	113	18	.	.	PUNCT
biomedich-578	114	1	marine	marine	ADJ
biomedich-578	114	2	invertebrae	invertebrae	NOUN
biomedich-578	114	3	marine	marine	NOUN
biomedich-578	114	4	invertebrates	invertebrate	NOUN
biomedich-578	114	5	include	include	VERB
biomedich-578	114	6	sponges	sponge	NOUN
biomedich-578	114	7	,	,	PUNCT
biomedich-578	114	8	ascidians	ascidian	NOUN
biomedich-578	114	9	/	/	SYM
biomedich-578	114	10	tunicates	tunicate	NOUN
biomedich-578	114	11	,	,	PUNCT
biomedich-578	114	12	echinoderms	echinoderm	NOUN
biomedich-578	114	13	,	,	PUNCT
biomedich-578	114	14	gorgonians	gorgonian	NOUN
biomedich-578	114	15	/	/	SYM
biomedich-578	114	16	octocorals	octocoral	NOUN
biomedich-578	114	17	,	,	PUNCT
biomedich-578	114	18	molluscs	mollusc	NOUN
biomedich-578	114	19	(	(	PUNCT
biomedich-578	114	20	such	such	ADJ
biomedich-578	114	21	as	as	ADP
biomedich-578	114	22	octopuses	octopus	NOUN
biomedich-578	114	23	,	,	PUNCT
biomedich-578	114	24	squids	squids	PROPN
biomedich-578	114	25	,	,	PUNCT
biomedich-578	114	26	clams	clams	NOUN
biomedich-578	114	27	,	,	PUNCT
biomedich-578	114	28	snails	snail	NOUN
biomedich-578	114	29	)	)	PUNCT
biomedich-578	114	30	,	,	PUNCT
biomedich-578	114	31	and	and	CCONJ
biomedich-578	114	32	arthropods	arthropod	NOUN
biomedich-578	114	33	(	(	PUNCT
biomedich-578	114	34	such	such	ADJ
biomedich-578	114	35	as	as	ADP
biomedich-578	114	36	crabs	crab	NOUN
biomedich-578	114	37	,	,	PUNCT
biomedich-578	114	38	shrimp	shrimp	NOUN
biomedich-578	114	39	,	,	PUNCT
biomedich-578	114	40	and	and	CCONJ
biomedich-578	114	41	lobsters	lobster	NOUN
biomedich-578	114	42	)	)	PUNCT
biomedich-578	114	43	.	.	PUNCT
biomedich-578	115	1	marine	marine	PROPN
biomedich-578	115	2	sponges	sponge	NOUN
biomedich-578	115	3	spongionella	spongionella	NOUN
biomedich-578	115	4	gracilis	gracilis	PROPN
biomedich-578	115	5	contains	contain	VERB
biomedich-578	115	6	gracilin	gracilin	PROPN
biomedich-578	115	7	(	(	PUNCT
biomedich-578	115	8	diterpenoid	diterpenoid	PROPN
biomedich-578	115	9	)	)	PUNCT
biomedich-578	115	10	,	,	PUNCT
biomedich-578	115	11	which	which	PRON
biomedich-578	115	12	exhibits	exhibit	VERB
biomedich-578	115	13	activity	activity	NOUN
biomedich-578	115	14	to	to	PART
biomedich-578	115	15	inhibit	inhibit	VERB
biomedich-578	115	16	bace-1	bace-1	PROPN
biomedich-578	115	17	.	.	PUNCT
biomedich-578	116	1	gracilin	gracilin	PROPN
biomedich-578	116	2	has	have	VERB
biomedich-578	116	3	anti	anti	ADJ
biomedich-578	116	4	-	-	ADJ
biomedich-578	116	5	inflammatory	inflammatory	ADJ
biomedich-578	116	6	and	and	CCONJ
biomedich-578	116	7	antioxidant	antioxidant	ADJ
biomedich-578	116	8	effects	effect	NOUN
biomedich-578	116	9	through	through	ADP
biomedich-578	116	10	the	the	DET
biomedich-578	116	11	induction	induction	NOUN
biomedich-578	116	12	of	of	ADP
biomedich-578	116	13	nrf2	nrf2	NOUN
biomedich-578	116	14	,	,	PUNCT
biomedich-578	116	15	thereby	thereby	ADV
biomedich-578	116	16	inhibiting	inhibit	VERB
biomedich-578	116	17	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	116	18	of	of	ADP
biomedich-578	116	19	tau	tau	PROPN
biomedich-578	116	20	proteins	protein	NOUN
biomedich-578	116	21	.	.	PUNCT
biomedich-578	117	1	marine	marine	PROPN
biomedich-578	117	2	sponges	sponges	PROPN
biomedich-578	117	3	haliclona	haliclona	PROPN
biomedich-578	117	4	sp	sp	PROPN
biomedich-578	117	5	.	.	PROPN
biomedich-578	117	6	and	and	CCONJ
biomedich-578	117	7	acanthostrongylophora	acanthostrongylophora	PROPN
biomedich-578	117	8	contain	contain	VERB
biomedich-578	117	9	manzamine	manzamine	NOUN
biomedich-578	117	10	(	(	PUNCT
biomedich-578	117	11	an	an	DET
biomedich-578	117	12	alkaloid	alkaloid	NOUN
biomedich-578	117	13	)	)	PUNCT
biomedich-578	117	14	which	which	PRON
biomedich-578	117	15	can	can	AUX
biomedich-578	117	16	inhibit	inhibit	VERB
biomedich-578	117	17	gsk-3	gsk-3	PUNCT
biomedich-578	117	18	and	and	CCONJ
biomedich-578	117	19	reduce	reduce	VERB
biomedich-578	117	20	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	117	21	of	of	ADP
biomedich-578	117	22	tau	tau	PROPN
biomedich-578	117	23	proteins	protein	NOUN
biomedich-578	117	24	(	(	PUNCT
biomedich-578	117	25	hu	hu	PROPN
biomedich-578	117	26	et	et	PROPN
biomedich-578	117	27	al	al	PROPN
biomedich-578	117	28	.	.	PROPN
biomedich-578	117	29	,	,	PUNCT
biomedich-578	117	30	2013	2013	NUM
biomedich-578	117	31	;	;	PUNCT
biomedich-578	117	32	kabir	kabir	PROPN
biomedich-578	117	33	et	et	PROPN
biomedich-578	117	34	al	al	PROPN
biomedich-578	117	35	.	.	PROPN
biomedich-578	117	36	,	,	PUNCT
biomedich-578	117	37	2021	2021	NUM
biomedich-578	117	38	)	)	PUNCT
biomedich-578	117	39	.	.	PUNCT
biomedich-578	118	1	from	from	ADP
biomedich-578	118	2	the	the	DET
biomedich-578	118	3	marine	marine	ADJ
biomedich-578	118	4	sponge	sponge	NOUN
biomedich-578	118	5	fascaplysinopsis	fascaplysinopsis	NOUN
biomedich-578	118	6	bergquist	bergquist	NOUN
biomedich-578	118	7	sp	sp	PROPN
biomedich-578	118	8	.	.	PROPN
biomedich-578	118	9	,	,	PUNCT
biomedich-578	118	10	an	an	DET
biomedich-578	118	11	alkaloid	alkaloid	NOUN
biomedich-578	118	12	called	call	VERB
biomedich-578	118	13	fascaplysin	fascaplysin	NOUN
biomedich-578	118	14	has	have	AUX
biomedich-578	118	15	been	be	AUX
biomedich-578	118	16	isolated	isolate	VERB
biomedich-578	118	17	,	,	PUNCT
biomedich-578	118	18	which	which	PRON
biomedich-578	118	19	is	be	AUX
biomedich-578	118	20	known	know	VERB
biomedich-578	118	21	to	to	PART
biomedich-578	118	22	increase	increase	VERB
biomedich-578	118	23	the	the	DET
biomedich-578	118	24	efflux	efflux	NOUN
biomedich-578	118	25	or	or	CCONJ
biomedich-578	118	26	clearance	clearance	NOUN
biomedich-578	118	27	of	of	ADP
biomedich-578	118	28	aβ	aβ	NOUN
biomedich-578	118	29	by	by	ADP
biomedich-578	118	30	increasing	increase	VERB
biomedich-578	118	31	the	the	DET
biomedich-578	118	32	level	level	NOUN
biomedich-578	118	33	of	of	ADP
biomedich-578	118	34	p	p	NOUN
biomedich-578	118	35	-	-	PUNCT
biomedich-578	118	36	glycoprotein	glycoprotein	NOUN
biomedich-578	118	37	.	.	PUNCT
biomedich-578	119	1	a	a	DET
biomedich-578	119	2	synthetic	synthetic	ADJ
biomedich-578	119	3	derivative	derivative	NOUN
biomedich-578	119	4	of	of	ADP
biomedich-578	119	5	fascaplysin	fascaplysin	NOUN
biomedich-578	119	6	,	,	PUNCT
biomedich-578	119	7	9	9	NUM
biomedich-578	119	8	-	-	PUNCT
biomedich-578	119	9	methylfascaplysin	methylfascaplysin	NOUN
biomedich-578	119	10	,	,	PUNCT
biomedich-578	119	11	has	have	VERB
biomedich-578	119	12	more	more	ADV
biomedich-578	119	13	significant	significant	ADJ
biomedich-578	119	14	potential	potential	NOUN
biomedich-578	119	15	in	in	ADP
biomedich-578	119	16	inhibiting	inhibit	VERB
biomedich-578	119	17	the	the	DET
biomedich-578	119	18	formation	formation	NOUN
biomedich-578	119	19	of	of	ADP
biomedich-578	119	20	aβ	aβ	PRON
biomedich-578	119	21	peptide	peptide	NOUN
biomedich-578	119	22	,	,	PUNCT
biomedich-578	119	23	fibrillation	fibrillation	NOUN
biomedich-578	119	24	of	of	ADP
biomedich-578	119	25	aβ	aβ	NOUN
biomedich-578	119	26	,	,	PUNCT
biomedich-578	119	27	and	and	CCONJ
biomedich-578	119	28	ache	ache	ADV
biomedich-578	119	29	.	.	PUNCT
biomedich-578	120	1	additionally	additionally	ADV
biomedich-578	120	2	,	,	PUNCT
biomedich-578	120	3	this	this	DET
biomedich-578	120	4	derivative	derivative	ADJ
biomedich-578	120	5	compound	compound	NOUN
biomedich-578	120	6	has	have	VERB
biomedich-578	120	7	the	the	DET
biomedich-578	120	8	potential	potential	NOUN
biomedich-578	120	9	to	to	PART
biomedich-578	120	10	activate	activate	VERB
biomedich-578	120	11	antioxidant	antioxidant	ADJ
biomedich-578	120	12	enzymes	enzyme	NOUN
biomedich-578	120	13	that	that	PRON
biomedich-578	120	14	counteract	counteract	VERB
biomedich-578	120	15	ros	ros	PROPN
biomedich-578	120	16	,	,	PUNCT
biomedich-578	120	17	reduce	reduce	VERB
biomedich-578	120	18	neuroinflammation	neuroinflammation	NOUN
biomedich-578	120	19	,	,	PUNCT
biomedich-578	120	20	and	and	CCONJ
biomedich-578	120	21	decrease	decrease	VERB
biomedich-578	120	22	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	120	23	of	of	ADP
biomedich-578	120	24	tau	tau	PROPN
biomedich-578	120	25	(	(	PUNCT
biomedich-578	120	26	martins	martin	NOUN
biomedich-578	120	27	et	et	NOUN
biomedich-578	120	28	al	al	PROPN
biomedich-578	120	29	.	.	PROPN
biomedich-578	120	30	,	,	PUNCT
biomedich-578	120	31	2020	2020	NUM
biomedich-578	120	32	)	)	PUNCT
biomedich-578	120	33	.	.	PUNCT
biomedich-578	121	1	maldives	maldives	PROPN
biomedich-578	121	2	sponge	sponge	VERB
biomedich-578	121	3	spongia	spongia	NOUN
biomedich-578	121	4	sp	sp	PROPN
biomedich-578	121	5	.	.	PROPN
biomedich-578	121	6	impact	impact	VERB
biomedich-578	121	7	the	the	DET
biomedich-578	121	8	reduction	reduction	NOUN
biomedich-578	121	9	of	of	ADP
biomedich-578	121	10	tau	tau	PROPN
biomedich-578	121	11	pathology	pathology	NOUN
biomedich-578	121	12	due	due	ADP
biomedich-578	121	13	to	to	ADP
biomedich-578	121	14	the	the	DET
biomedich-578	121	15	presence	presence	NOUN
biomedich-578	121	16	of	of	ADP
biomedich-578	121	17	dictyostatine	dictyostatine	NOUN
biomedich-578	121	18	(	(	PUNCT
biomedich-578	121	19	marine	marine	ADV
biomedich-578	121	20	derived	derive	VERB
biomedich-578	121	21	macrolide	macrolide	NOUN
biomedich-578	121	22	)	)	PUNCT
biomedich-578	121	23	inside	inside	ADV
biomedich-578	121	24	(	(	PUNCT
biomedich-578	121	25	xia	xia	PROPN
biomedich-578	121	26	et	et	PROPN
biomedich-578	121	27	al	al	PROPN
biomedich-578	121	28	.	.	PROPN
biomedich-578	121	29	,	,	PUNCT
biomedich-578	121	30	2019	2019	NUM
biomedich-578	121	31	;	;	PUNCT
biomedich-578	121	32	kabir	kabir	PROPN
biomedich-578	121	33	et	et	PROPN
biomedich-578	121	34	al	al	PROPN
biomedich-578	121	35	.	.	PROPN
biomedich-578	121	36	,	,	PUNCT
biomedich-578	121	37	2021	2021	NUM
biomedich-578	121	38	)	)	PUNCT
biomedich-578	121	39	.	.	PUNCT
biomedich-578	122	1	from	from	ADP
biomedich-578	122	2	the	the	DET
biomedich-578	122	3	marine	marine	ADJ
biomedich-578	122	4	sponge	sponge	NOUN
biomedich-578	122	5	haliclona	haliclona	NOUN
biomedich-578	122	6	moorei	moorei	ADJ
biomedich-578	122	7	and	and	CCONJ
biomedich-578	122	8	the	the	DET
biomedich-578	122	9	tunicate	tunicate	NOUN
biomedich-578	122	10	aplidium	aplidium	NOUN
biomedich-578	122	11	conicum	conicum	NOUN
biomedich-578	122	12	,	,	PUNCT
biomedich-578	122	13	a	a	DET
biomedich-578	122	14	natural	natural	ADJ
biomedich-578	122	15	alkaloid	alkaloid	NOUN
biomedich-578	122	16	compound	compound	NOUN
biomedich-578	122	17	that	that	PRON
biomedich-578	122	18	resembles	resemble	VERB
biomedich-578	122	19	nicotine	nicotine	NOUN
biomedich-578	122	20	,	,	PUNCT
biomedich-578	122	21	called	call	VERB
biomedich-578	122	22	anabasine	anabasine	ADJ
biomedich-578	122	23	,	,	PUNCT
biomedich-578	122	24	has	have	AUX
biomedich-578	122	25	been	be	AUX
biomedich-578	122	26	isolated	isolate	VERB
biomedich-578	122	27	.	.	PUNCT
biomedich-578	123	1	this	this	DET
biomedich-578	123	2	compound	compound	NOUN
biomedich-578	123	3	and	and	CCONJ
biomedich-578	123	4	its	its	PRON
biomedich-578	123	5	synthetic	synthetic	ADJ
biomedich-578	123	6	analogues	analogue	NOUN
biomedich-578	123	7	are	be	AUX
biomedich-578	123	8	known	know	VERB
biomedich-578	123	9	to	to	PART
biomedich-578	123	10	have	have	VERB
biomedich-578	123	11	neuroprotective	neuroprotective	ADJ
biomedich-578	123	12	effects	effect	NOUN
biomedich-578	123	13	by	by	ADP
biomedich-578	123	14	inhibiting	inhibit	VERB
biomedich-578	123	15	apoptosis	apoptosis	NOUN
biomedich-578	123	16	and	and	CCONJ
biomedich-578	123	17	necrosis	necrosis	NOUN
biomedich-578	123	18	in	in	ADP
biomedich-578	123	19	neurons	neuron	NOUN
biomedich-578	123	20	.	.	PUNCT
biomedich-578	124	1	additionally	additionally	ADV
biomedich-578	124	2	,	,	PUNCT
biomedich-578	124	3	one	one	NUM
biomedich-578	124	4	of	of	ADP
biomedich-578	124	5	its	its	PRON
biomedich-578	124	6	analogues	analogue	NOUN
biomedich-578	124	7	,	,	PUNCT
biomedich-578	124	8	gts-21	gts-21	PROPN
biomedich-578	124	9	,	,	PUNCT
biomedich-578	124	10	can	can	AUX
biomedich-578	124	11	reduce	reduce	VERB
biomedich-578	124	12	the	the	DET
biomedich-578	124	13	amount	amount	NOUN
biomedich-578	124	14	of	of	ADP
biomedich-578	124	15	aβ	aβ	NOUN
biomedich-578	124	16	,	,	PUNCT
biomedich-578	124	17	inhibit	inhibit	VERB
biomedich-578	124	18	the	the	DET
biomedich-578	124	19	activity	activity	NOUN
biomedich-578	124	20	of	of	ADP
biomedich-578	124	21	γ	γ	NOUN
biomedich-578	124	22	-	-	PUNCT
biomedich-578	124	23	secretase	secretase	NOUN
biomedich-578	124	24	,	,	PUNCT
biomedich-578	124	25	and	and	CCONJ
biomedich-578	124	26	promote	promote	VERB
biomedich-578	124	27	aβ	aβ	PRON
biomedich-578	124	28	clearance	clearance	NOUN
biomedich-578	124	29	through	through	ADP
biomedich-578	124	30	phagocytosis	phagocytosis	NOUN
biomedich-578	124	31	(	(	PUNCT
biomedich-578	124	32	martins	martin	NOUN
biomedich-578	124	33	et	et	NOUN
biomedich-578	124	34	al	al	PROPN
biomedich-578	124	35	.	.	PROPN
biomedich-578	124	36	,	,	PUNCT
biomedich-578	124	37	2020	2020	NUM
biomedich-578	124	38	)	)	PUNCT
biomedich-578	124	39	.	.	PUNCT
biomedich-578	125	1	ascidian	ascidian	PROPN
biomedich-578	125	2	styela	styela	PROPN
biomedich-578	125	3	plicata	plicata	NOUN
biomedich-578	125	4	contains	contain	VERB
biomedich-578	125	5	heparin	heparin	NOUN
biomedich-578	125	6	,	,	PUNCT
biomedich-578	125	7	which	which	PRON
biomedich-578	125	8	influences	influence	VERB
biomedich-578	125	9	neuronal	neuronal	ADJ
biomedich-578	125	10	cell	cell	NOUN
biomedich-578	125	11	death	death	NOUN
biomedich-578	125	12	by	by	ADP
biomedich-578	125	13	reducing	reduce	VERB
biomedich-578	125	14	aβ	aβ	NOUN
biomedich-578	125	15	.	.	NOUN
biomedich-578	125	16	sea	sea	NOUN
biomedich-578	125	17	cucumber	cucumber	NOUN
biomedich-578	125	18	acaudina	acaudina	NOUN
biomedich-578	125	19	molpadioides	molpadioide	NOUN
biomedich-578	125	20	,	,	PUNCT
biomedich-578	125	21	which	which	PRON
biomedich-578	125	22	belongs	belong	VERB
biomedich-578	125	23	to	to	ADP
biomedich-578	125	24	the	the	DET
biomedich-578	125	25	class	class	NOUN
biomedich-578	125	26	echinodermata	echinodermata	NOUN
biomedich-578	125	27	,	,	PUNCT
biomedich-578	125	28	is	be	AUX
biomedich-578	125	29	known	know	VERB
biomedich-578	125	30	to	to	PART
biomedich-578	125	31	contain	contain	VERB
biomedich-578	125	32	a	a	DET
biomedich-578	125	33	mixture	mixture	NOUN
biomedich-578	125	34	of	of	ADP
biomedich-578	125	35	glycosphingolipids	glycosphingolipid	NOUN
biomedich-578	125	36	that	that	PRON
biomedich-578	125	37	can	can	AUX
biomedich-578	125	38	reduce	reduce	VERB
biomedich-578	125	39	cognitive	cognitive	ADJ
biomedich-578	125	40	deficits	deficit	NOUN
biomedich-578	125	41	caused	cause	VERB
biomedich-578	125	42	by	by	ADP
biomedich-578	125	43	the	the	DET
biomedich-578	125	44	aβ1–42	aβ1–42	PROPN
biomedich-578	125	45	peptide	peptide	NOUN
biomedich-578	125	46	(	(	PUNCT
biomedich-578	125	47	carroll	carroll	PROPN
biomedich-578	125	48	et	et	PROPN
biomedich-578	125	49	al	al	PROPN
biomedich-578	125	50	.	.	PROPN
biomedich-578	125	51	,	,	PUNCT
biomedich-578	125	52	2021	2021	NUM
biomedich-578	125	53	)	)	PUNCT
biomedich-578	125	54	.	.	PUNCT
biomedich-578	126	1	various	various	ADJ
biomedich-578	126	2	species	specie	NOUN
biomedich-578	126	3	of	of	ADP
biomedich-578	126	4	clams	clams	NOUN
biomedich-578	126	5	(	(	PUNCT
biomedich-578	126	6	anomalocardia	anomalocardia	PROPN
biomedich-578	126	7	brasiliana	brasiliana	PROPN
biomedich-578	126	8	,	,	PUNCT
biomedich-578	126	9	tivela	tivela	PROPN
biomedich-578	126	10	mactroides	mactroide	NOUN
biomedich-578	126	11	,	,	PUNCT
biomedich-578	126	12	donax	donax	NOUN
biomedich-578	126	13	striatus	striatus	NOUN
biomedich-578	126	14	,	,	PUNCT
biomedich-578	126	15	and	and	CCONJ
biomedich-578	126	16	tapes	tape	NOUN
biomedich-578	126	17	phlippinarum	phlippinarum	PROPN
biomedich-578	126	18	)	)	PUNCT
biomedich-578	126	19	,	,	PUNCT
biomedich-578	126	20	scallop	scallop	VERB
biomedich-578	126	21	nodipecten	nodipecten	VERB
biomedich-578	126	22	nodosus	nodosus	NOUN
biomedich-578	126	23	,	,	PUNCT
biomedich-578	126	24	sand	sand	NOUN
biomedich-578	126	25	dollar	dollar	NOUN
biomedich-578	126	26	mellita	mellita	NOUN
biomedich-578	126	27	quinquisperforata	quinquisperforata	PROPN
biomedich-578	126	28	,	,	PUNCT
biomedich-578	126	29	and	and	CCONJ
biomedich-578	126	30	cockle	cockle	PROPN
biomedich-578	126	31	cerastoderma	cerastoderma	PROPN
biomedich-578	126	32	edule	edule	NOUN
biomedich-578	126	33	are	be	AUX
biomedich-578	126	34	known	know	VERB
biomedich-578	126	35	to	to	PART
biomedich-578	126	36	contain	contain	VERB
biomedich-578	126	37	heparin	heparin	NOUN
biomedich-578	126	38	,	,	PUNCT
biomedich-578	126	39	which	which	PRON
biomedich-578	126	40	influences	influence	VERB
biomedich-578	126	41	neuronal	neuronal	ADJ
biomedich-578	126	42	cell	cell	NOUN
biomedich-578	126	43	death	death	NOUN
biomedich-578	126	44	by	by	ADP
biomedich-578	126	45	reducing	reduce	VERB
biomedich-578	126	46	aβ	aβ	NUM
biomedich-578	126	47	.	.	NOUN
biomedich-578	126	48	white	white	PROPN
biomedich-578	126	49	leg	leg	PROPN
biomedich-578	126	50	shrimp	shrimp	PROPN
biomedich-578	126	51	litopenaeus	litopenaeus	PROPN
biomedich-578	126	52	vannamei	vannamei	PROPN
biomedich-578	126	53	and	and	CCONJ
biomedich-578	126	54	crabs	crab	NOUN
biomedich-578	126	55	(	(	PUNCT
biomedich-578	126	56	goniopsis	goniopsis	NOUN
biomedich-578	126	57	cruentata	cruentata	NOUN
biomedich-578	126	58	and	and	CCONJ
biomedich-578	126	59	ucides	ucides	PROPN
biomedich-578	126	60	cordatus	cordatus	NOUN
biomedich-578	126	61	)	)	PUNCT
biomedich-578	126	62	,	,	PUNCT
biomedich-578	126	63	are	be	AUX
biomedich-578	126	64	also	also	ADV
biomedich-578	126	65	known	know	VERB
biomedich-578	126	66	to	to	PART
biomedich-578	126	67	contain	contain	VERB
biomedich-578	126	68	heparin	heparin	ADJ
biomedich-578	126	69	(	(	PUNCT
biomedich-578	126	70	bălașa	bălașa	NOUN
biomedich-578	126	71	et	et	PROPN
biomedich-578	126	72	al	al	PROPN
biomedich-578	126	73	.	.	PROPN
biomedich-578	126	74	,	,	PUNCT
biomedich-578	126	75	2020	2020	NUM
biomedich-578	126	76	)	)	PUNCT
biomedich-578	126	77	.	.	PUNCT
biomedich-578	127	1	glycosaminoglicans	glycosaminoglican	NOUN
biomedich-578	127	2	including	include	VERB
biomedich-578	127	3	chondroitin	chondroitin	NOUN
biomedich-578	127	4	sulphate	sulphate	NOUN
biomedich-578	127	5	(	(	PUNCT
biomedich-578	127	6	cs	cs	PROPN
biomedich-578	127	7	)	)	PUNCT
biomedich-578	127	8	,	,	PUNCT
biomedich-578	127	9	heparan	heparan	ADJ
biomedich-578	127	10	sulfate	sulfate	NOUN
biomedich-578	127	11	(	(	PUNCT
biomedich-578	127	12	hs	hs	X
biomedich-578	127	13	)	)	PUNCT
biomedich-578	127	14	,	,	PUNCT
biomedich-578	127	15	and	and	CCONJ
biomedich-578	127	16	dermatan	dermatan	PROPN
biomedich-578	127	17	sulphate	sulphate	NOUN
biomedich-578	127	18	(	(	PUNCT
biomedich-578	127	19	ds	ds	NOUN
biomedich-578	127	20	)	)	PUNCT
biomedich-578	127	21	,	,	PUNCT
biomedich-578	127	22	from	from	ADP
biomedich-578	127	23	litopenaeus	litopenaeus	PROPN
biomedich-578	127	24	vannamei	vannamei	PROPN
biomedich-578	127	25	demonstrates	demonstrate	VERB
biomedich-578	127	26	the	the	DET
biomedich-578	127	27	ability	ability	NOUN
biomedich-578	127	28	to	to	PART
biomedich-578	127	29	reduce	reduce	VERB
biomedich-578	127	30	cognitive	cognitive	ADJ
biomedich-578	127	31	and	and	CCONJ
biomedich-578	127	32	ad	ad	NOUN
biomedich-578	127	33	related	relate	VERB
biomedich-578	127	34	memory	memory	NOUN
biomedich-578	127	35	impairments	impairment	NOUN
biomedich-578	127	36	by	by	ADP
biomedich-578	127	37	inhibiting	inhibit	VERB
biomedich-578	127	38	the	the	DET
biomedich-578	127	39	bace-1	bace-1	PROPN
biomedich-578	127	40	activity	activity	NOUN
biomedich-578	127	41	(	(	PUNCT
biomedich-578	127	42	carroll	carroll	PROPN
biomedich-578	127	43	et	et	PROPN
biomedich-578	127	44	al	al	PROPN
biomedich-578	127	45	.	.	PROPN
biomedich-578	127	46	,	,	PUNCT
biomedich-578	127	47	2021	2021	NUM
biomedich-578	127	48	;	;	PUNCT
biomedich-578	127	49	mycroft	mycroft	PROPN
biomedich-578	127	50	-	-	PUNCT
biomedich-578	127	51	west	west	PROPN
biomedich-578	127	52	et	et	PROPN
biomedich-578	127	53	al	al	PROPN
biomedich-578	127	54	.	.	PROPN
biomedich-578	127	55	,	,	PUNCT
biomedich-578	127	56	2021	2021	NUM
biomedich-578	127	57	)	)	PUNCT
biomedich-578	127	58	.	.	PUNCT
biomedich-578	128	1	bugula	bugula	NOUN
biomedich-578	128	2	neritina	neritina	NOUN
biomedich-578	128	3	contains	contain	VERB
biomedich-578	128	4	bryostatin-1	bryostatin-1	PROPN
biomedich-578	128	5	,	,	PUNCT
biomedich-578	128	6	a	a	DET
biomedich-578	128	7	macrolide	macrolide	NOUN
biomedich-578	128	8	lactone	lactone	NOUN
biomedich-578	128	9	that	that	PRON
biomedich-578	128	10	can	can	AUX
biomedich-578	128	11	modulate	modulate	VERB
biomedich-578	128	12	pkcε	pkcε	NOUN
biomedich-578	128	13	,	,	PUNCT
biomedich-578	128	14	leading	lead	VERB
biomedich-578	128	15	to	to	ADP
biomedich-578	128	16	the	the	DET
biomedich-578	128	17	degradation	degradation	NOUN
biomedich-578	128	18	of	of	ADP
biomedich-578	128	19	aβ	aβ	NOUN
biomedich-578	128	20	,	,	PUNCT
biomedich-578	128	21	activation	activation	NOUN
biomedich-578	128	22	of	of	ADP
biomedich-578	128	23	αsecretase	αsecretase	NOUN
biomedich-578	128	24	,	,	PUNCT
biomedich-578	128	25	and	and	CCONJ
biomedich-578	128	26	reduction	reduction	NOUN
biomedich-578	128	27	of	of	ADP
biomedich-578	128	28	tau	tau	PROPN
biomedich-578	128	29	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	128	30	through	through	ADP
biomedich-578	128	31	gsk-3β	gsk-3β	ADJ
biomedich-578	128	32	activity	activity	NOUN
biomedich-578	128	33	(	(	PUNCT
biomedich-578	128	34	martins	martin	NOUN
biomedich-578	128	35	et	et	NOUN
biomedich-578	128	36	al	al	PROPN
biomedich-578	128	37	.	.	PROPN
biomedich-578	128	38	,	,	PUNCT
biomedich-578	128	39	2020	2020	NUM
biomedich-578	128	40	;	;	PUNCT
biomedich-578	128	41	kabir	kabir	PROPN
biomedich-578	128	42	et	et	PROPN
biomedich-578	128	43	al	al	PROPN
biomedich-578	128	44	.	.	PROPN
biomedich-578	128	45	,	,	PUNCT
biomedich-578	128	46	2021	2021	NUM
biomedich-578	128	47	;	;	PUNCT
biomedich-578	128	48	botelho	botelho	NOUN
biomedich-578	128	49	et	et	PROPN
biomedich-578	128	50	al	al	PROPN
biomedich-578	128	51	.	.	PROPN
biomedich-578	128	52	,	,	PUNCT
biomedich-578	128	53	2022	2022	NUM
biomedich-578	128	54	)	)	PUNCT
biomedich-578	128	55	.	.	PUNCT
biomedich-578	129	1	marine	marine	PROPN
biomedich-578	129	2	worm	worm	NOUN
biomedich-578	129	3	nemertines	nemertine	NOUN
biomedich-578	129	4	have	have	VERB
biomedich-578	129	5	anabasaine	anabasaine	NOUN
biomedich-578	129	6	that	that	PRON
biomedich-578	129	7	can	can	AUX
biomedich-578	129	8	stimulate	stimulate	VERB
biomedich-578	129	9	various	various	ADJ
biomedich-578	129	10	animal	animal	NOUN
biomedich-578	129	11	nachr	nachr	NOUN
biomedich-578	129	12	(	(	PUNCT
biomedich-578	129	13	kabir	kabir	PROPN
biomedich-578	129	14	et	et	PROPN
biomedich-578	129	15	al	al	PROPN
biomedich-578	129	16	.	.	PROPN
biomedich-578	129	17	,	,	PUNCT
biomedich-578	129	18	2021	2021	NUM
biomedich-578	129	19	)	)	PUNCT
biomedich-578	129	20	.	.	PUNCT
biomedich-578	130	1	algae	algae	NOUN
biomedich-578	130	2	in	in	ADP
biomedich-578	130	3	the	the	DET
biomedich-578	130	4	effort	effort	NOUN
biomedich-578	130	5	to	to	PART
biomedich-578	130	6	develop	develop	VERB
biomedich-578	130	7	marine	marine	ADJ
biomedich-578	130	8	-	-	PUNCT
biomedich-578	130	9	derived	derive	VERB
biomedich-578	130	10	medicines	medicine	NOUN
biomedich-578	130	11	as	as	ADP
biomedich-578	130	12	neuroprotective	neuroprotective	ADJ
biomedich-578	130	13	agents	agent	NOUN
biomedich-578	130	14	,	,	PUNCT
biomedich-578	130	15	the	the	DET
biomedich-578	130	16	brown	brown	ADJ
biomedich-578	130	17	algae	algae	NOUN
biomedich-578	130	18	ecklonia	ecklonia	NOUN
biomedich-578	130	19	cava	cava	NOUN
biomedich-578	130	20	has	have	AUX
biomedich-578	130	21	been	be	AUX
biomedich-578	130	22	studied	study	VERB
biomedich-578	130	23	and	and	CCONJ
biomedich-578	130	24	is	be	AUX
biomedich-578	130	25	known	know	VERB
biomedich-578	130	26	to	to	PART
biomedich-578	130	27	reduce	reduce	VERB
biomedich-578	130	28	the	the	DET
biomedich-578	130	29	production	production	NOUN
biomedich-578	130	30	of	of	ADP
biomedich-578	130	31	aβ	aβ	PROPN
biomedich-578	130	32	,	,	PUNCT
biomedich-578	130	33	tau	tau	PROPN
biomedich-578	130	34	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	130	35	,	,	PUNCT
biomedich-578	130	36	and	and	CCONJ
biomedich-578	130	37	neuroinflammatory	neuroinflammatory	NOUN
biomedich-578	130	38	markers	marker	NOUN
biomedich-578	130	39	(	(	PUNCT
biomedich-578	130	40	nfκb	nfκb	NOUN
biomedich-578	130	41	and	and	CCONJ
biomedich-578	130	42	stat3	stat3	NOUN
biomedich-578	130	43	)	)	PUNCT
biomedich-578	130	44	due	due	ADP
biomedich-578	130	45	to	to	ADP
biomedich-578	130	46	its	its	PRON
biomedich-578	130	47	fucoidan	fucoidan	ADJ
biomedich-578	130	48	content	content	NOUN
biomedich-578	130	49	(	(	PUNCT
biomedich-578	130	50	park	park	NOUN
biomedich-578	130	51	et	et	PROPN
biomedich-578	130	52	al	al	PROPN
biomedich-578	130	53	.	.	PROPN
biomedich-578	130	54	,	,	PUNCT
biomedich-578	130	55	2019	2019	NUM
biomedich-578	130	56	;	;	PUNCT
biomedich-578	130	57	jo	jo	PROPN
biomedich-578	130	58	et	et	PROPN
biomedich-578	130	59	al	al	PROPN
biomedich-578	130	60	.	.	PROPN
biomedich-578	130	61	,	,	PUNCT
biomedich-578	130	62	2023	2023	NUM
biomedich-578	130	63	)	)	PUNCT
biomedich-578	130	64	.	.	PUNCT
biomedich-578	131	1	the	the	DET
biomedich-578	131	2	phlorotannin	phlorotannin	NOUN
biomedich-578	131	3	content	content	NOUN
biomedich-578	131	4	of	of	ADP
biomedich-578	131	5	ecklonia	ecklonia	NOUN
biomedich-578	131	6	cava	cava	NOUN
biomedich-578	131	7	,	,	PUNCT
biomedich-578	131	8	including	include	VERB
biomedich-578	131	9	dieckol	dieckol	PROPN
biomedich-578	131	10	,	,	PUNCT
biomedich-578	131	11	eckol	eckol	NOUN
biomedich-578	131	12	,	,	PUNCT
biomedich-578	131	13	and	and	CCONJ
biomedich-578	131	14	8,8′-bieckol	8,8′-bieckol	PROPN
biomedich-578	131	15	,	,	PUNCT
biomedich-578	131	16	has	have	VERB
biomedich-578	131	17	inhibitory	inhibitory	ADJ
biomedich-578	131	18	effects	effect	NOUN
biomedich-578	131	19	on	on	ADP
biomedich-578	131	20	bace-1	bace-1	PROPN
biomedich-578	131	21	and	and	CCONJ
biomedich-578	131	22	antiinflammatory	antiinflammatory	NOUN
biomedich-578	131	23	effects	effect	NOUN
biomedich-578	131	24	through	through	ADP
biomedich-578	131	25	the	the	DET
biomedich-578	131	26	inactivation	inactivation	NOUN
biomedich-578	131	27	of	of	ADP
biomedich-578	131	28	the	the	DET
biomedich-578	131	29	nfκb	nfκb	ADJ
biomedich-578	131	30	pathway	pathway	NOUN
biomedich-578	131	31	.	.	PUNCT
biomedich-578	132	1	dieckol	dieckol	NOUN
biomedich-578	132	2	is	be	AUX
biomedich-578	132	3	known	know	VERB
biomedich-578	132	4	for	for	ADP
biomedich-578	132	5	its	its	PRON
biomedich-578	132	6	high	high	ADJ
biomedich-578	132	7	ability	ability	NOUN
biomedich-578	132	8	to	to	PART
biomedich-578	132	9	inhibit	inhibit	VERB
biomedich-578	132	10	the	the	DET
biomedich-578	132	11	accumulation	accumulation	NOUN
biomedich-578	132	12	of	of	ADP
biomedich-578	132	13	aβ	aβ	NOUN
biomedich-578	132	14	peptide	peptide	NOUN
biomedich-578	132	15	through	through	ADP
biomedich-578	132	16	the	the	DET
biomedich-578	132	17	regulation	regulation	NOUN
biomedich-578	132	18	of	of	ADP
biomedich-578	132	19	app	app	NOUN
biomedich-578	132	20	proteolysis	proteolysis	NOUN
biomedich-578	132	21	and	and	CCONJ
biomedich-578	132	22	aβ	aβ	PRON
biomedich-578	132	23	production	production	NOUN
biomedich-578	132	24	via	via	ADP
biomedich-578	132	25	the	the	DET
biomedich-578	132	26	gsk-3β	gsk-3β	ADJ
biomedich-578	132	27	signalling	signal	VERB
biomedich-578	132	28	pathway	pathway	NOUN
biomedich-578	132	29	(	(	PUNCT
biomedich-578	132	30	mehta	mehta	PROPN
biomedich-578	132	31	et	et	PROPN
biomedich-578	132	32	al	al	PROPN
biomedich-578	132	33	.	.	PROPN
biomedich-578	132	34	,	,	PUNCT
biomedich-578	132	35	2017	2017	NUM
biomedich-578	132	36	)	)	PUNCT
biomedich-578	132	37	.	.	PUNCT
biomedich-578	133	1	ecklonia	ecklonia	PROPN
biomedich-578	133	2	spp	spp	PROPN
biomedich-578	133	3	.	.	PUNCT
biomedich-578	133	4	is	be	AUX
biomedich-578	133	5	also	also	ADV
biomedich-578	133	6	known	know	VERB
biomedich-578	133	7	to	to	PART
biomedich-578	133	8	contain	contain	VERB
biomedich-578	133	9	mannuronate	mannuronate	ADJ
biomedich-578	133	10	oligosaccharides	oligosaccharide	NOUN
biomedich-578	133	11	that	that	PRON
biomedich-578	133	12	inhibit	inhibit	VERB
biomedich-578	133	13	aβ	aβ	DET
biomedich-578	133	14	aggregation	aggregation	NOUN
biomedich-578	133	15	and	and	CCONJ
biomedich-578	133	16	inhibit	inhibit	VERB
biomedich-578	133	17	bace-1	bace-1	PROPN
biomedich-578	133	18	production	production	NOUN
biomedich-578	133	19	,	,	PUNCT
biomedich-578	133	20	thereby	thereby	ADV
biomedich-578	133	21	reducing	reduce	VERB
biomedich-578	133	22	aβ	aβ	NOUN
biomedich-578	133	23	levels	level	NOUN
biomedich-578	133	24	(	(	PUNCT
biomedich-578	133	25	botelho	botelho	PROPN
biomedich-578	133	26	et	et	PROPN
biomedich-578	133	27	al	al	PROPN
biomedich-578	133	28	.	.	PROPN
biomedich-578	133	29	,	,	PUNCT
biomedich-578	133	30	2022	2022	NUM
biomedich-578	133	31	)	)	PUNCT
biomedich-578	133	32	.	.	PUNCT
biomedich-578	134	1	brown	brown	ADJ
biomedich-578	134	2	algae	algae	NOUN
biomedich-578	134	3	panida	panida	PROPN
biomedich-578	134	4	australis	australi	VERB
biomedich-578	134	5	and	and	CCONJ
biomedich-578	134	6	sargassum	sargassum	PROPN
biomedich-578	134	7	horridum	horridum	ADV
biomedich-578	134	8	contain	contain	VERB
biomedich-578	134	9	fucosterol	fucosterol	NOUN
biomedich-578	134	10	(	(	PUNCT
biomedich-578	134	11	sterol	sterol	NOUN
biomedich-578	134	12	)	)	PUNCT
biomedich-578	134	13	,	,	PUNCT
biomedich-578	134	14	which	which	PRON
biomedich-578	134	15	can	can	AUX
biomedich-578	134	16	prevent	prevent	VERB
biomedich-578	134	17	aβ	aβ	PRON
biomedich-578	134	18	oligomerization	oligomerization	NOUN
biomedich-578	134	19	,	,	PUNCT
biomedich-578	134	20	exhibit	exhibit	VERB
biomedich-578	134	21	antiinflammatory	antiinflammatory	NOUN
biomedich-578	134	22	and	and	CCONJ
biomedich-578	134	23	anti	anti	ADJ
biomedich-578	134	24	-	-	ADJ
biomedich-578	134	25	bace1	bace1	ADJ
biomedich-578	134	26	properties	property	NOUN
biomedich-578	134	27	.	.	PUNCT
biomedich-578	135	1	on	on	ADP
biomedich-578	135	2	the	the	DET
biomedich-578	135	3	other	other	ADJ
biomedich-578	135	4	hand	hand	NOUN
biomedich-578	135	5	,	,	PUNCT
biomedich-578	135	6	brown	brown	ADJ
biomedich-578	135	7	algae	algae	NOUN
biomedich-578	135	8	such	such	ADJ
biomedich-578	135	9	as	as	ADP
biomedich-578	135	10	sargassum	sargassum	NOUN
biomedich-578	135	11	siliquastrum	siliquastrum	AUX
biomedich-578	135	12	contain	contain	VERB
biomedich-578	135	13	fucoxanthin	fucoxanthin	NOUN
biomedich-578	135	14	,	,	PUNCT
biomedich-578	135	15	known	know	VERB
biomedich-578	135	16	for	for	ADP
biomedich-578	135	17	its	its	PRON
biomedich-578	135	18	antioxidant	antioxidant	ADJ
biomedich-578	135	19	and	and	CCONJ
biomedich-578	135	20	antiinflammatory	antiinflammatory	NOUN
biomedich-578	135	21	effects	effect	NOUN
biomedich-578	135	22	(	(	PUNCT
biomedich-578	135	23	hu	hu	PROPN
biomedich-578	135	24	et	et	PROPN
biomedich-578	135	25	al	al	PROPN
biomedich-578	135	26	.	.	PROPN
biomedich-578	135	27	,	,	PUNCT
biomedich-578	135	28	2023	2023	NUM
biomedich-578	135	29	)	)	PUNCT
biomedich-578	135	30	.	.	PUNCT
biomedich-578	136	1	brown	brown	ADJ
biomedich-578	136	2	alga	alga	ADJ
biomedich-578	136	3	dictyota	dictyota	NOUN
biomedich-578	136	4	coriacea	coriacea	PROPN
biomedich-578	136	5	isolated	isolate	VERB
biomedich-578	136	6	compound	compound	NOUN
biomedich-578	136	7	,	,	PUNCT
biomedich-578	136	8	dictyospiromide	dictyospiromide	ADV
biomedich-578	136	9	(	(	PUNCT
biomedich-578	136	10	a	a	DET
biomedich-578	136	11	diterpenoid	diterpenoid	ADJ
biomedich-578	136	12	-	-	PUNCT
biomedich-578	136	13	maleimide	maleimide	ADJ
biomedich-578	136	14	)	)	PUNCT
biomedich-578	136	15	is	be	AUX
biomedich-578	136	16	known	know	VERB
biomedich-578	136	17	to	to	PART
biomedich-578	136	18	have	have	VERB
biomedich-578	136	19	cytoprotective	cytoprotective	ADJ
biomedich-578	136	20	properties	property	NOUN
biomedich-578	136	21	and	and	CCONJ
biomedich-578	136	22	antioxidant	antioxidant	ADJ
biomedich-578	136	23	effects	effect	NOUN
biomedich-578	136	24	through	through	ADP
biomedich-578	136	25	activation	activation	NOUN
biomedich-578	136	26	of	of	ADP
biomedich-578	136	27	nrf2	nrf2	NOUN
biomedich-578	136	28	/	/	PUNCT
biomedich-578	136	29	are	be	AUX
biomedich-578	136	30	signaling	signal	VERB
biomedich-578	136	31	(	(	PUNCT
biomedich-578	136	32	carroll	carroll	PROPN
biomedich-578	136	33	et	et	PROPN
biomedich-578	136	34	al	al	PROPN
biomedich-578	136	35	.	.	PROPN
biomedich-578	136	36	,	,	PUNCT
biomedich-578	136	37	2021	2021	NUM
biomedich-578	136	38	)	)	PUNCT
biomedich-578	136	39	.	.	PUNCT
biomedich-578	137	1	from	from	ADP
biomedich-578	137	2	the	the	DET
biomedich-578	137	3	brown	brown	ADJ
biomedich-578	137	4	algae	algae	PROPN
biomedich-578	137	5	dictyopteris	dictyopteris	PROPN
biomedich-578	137	6	spp	spp	PROPN
biomedich-578	137	7	.	.	PROPN
biomedich-578	137	8	,	,	PUNCT
biomedich-578	137	9	zonarol	zonarol	PROPN
biomedich-578	137	10	has	have	AUX
biomedich-578	137	11	been	be	AUX
biomedich-578	137	12	isolated	isolate	VERB
biomedich-578	137	13	,	,	PUNCT
biomedich-578	137	14	which	which	PRON
biomedich-578	137	15	can	can	AUX
biomedich-578	137	16	protect	protect	VERB
biomedich-578	137	17	neurons	neuron	NOUN
biomedich-578	137	18	from	from	ADP
biomedich-578	137	19	damage	damage	NOUN
biomedich-578	137	20	due	due	ADP
biomedich-578	137	21	to	to	ADP
biomedich-578	137	22	oxidative	oxidative	ADJ
biomedich-578	137	23	stress	stress	NOUN
biomedich-578	137	24	(	(	PUNCT
biomedich-578	137	25	botelho	botelho	NOUN
biomedich-578	137	26	et	et	PROPN
biomedich-578	137	27	al	al	PROPN
biomedich-578	137	28	.	.	PROPN
biomedich-578	137	29	,	,	PUNCT
biomedich-578	137	30	2022	2022	NUM
biomedich-578	137	31	)	)	PUNCT
biomedich-578	137	32	.	.	PUNCT
biomedich-578	138	1	edible	edible	ADJ
biomedich-578	138	2	brown	brown	ADJ
biomedich-578	138	3	algae	algae	NOUN
biomedich-578	138	4	such	such	ADJ
biomedich-578	138	5	as	as	ADP
biomedich-578	138	6	laminaria	laminaria	PROPN
biomedich-578	138	7	hyperborea	hyperborea	NOUN
biomedich-578	138	8	,	,	PUNCT
biomedich-578	138	9	laminaria	laminaria	NOUN
biomedich-578	138	10	digitata	digitata	NOUN
biomedich-578	138	11	,	,	PUNCT
biomedich-578	138	12	macrocystis	macrocystis	PROPN
biomedich-578	138	13	pyrifera	pyrifera	NOUN
biomedich-578	138	14	,	,	PUNCT
biomedich-578	138	15	ascophyllum	ascophyllum	PROPN
biomedich-578	138	16	nodosum	nodosum	NOUN
biomedich-578	138	17	,	,	PUNCT
biomedich-578	138	18	and	and	CCONJ
biomedich-578	138	19	laminaria	laminaria	PROPN
biomedich-578	138	20	japonica	japonica	PROPN
biomedich-578	138	21	contain	contain	VERB
biomedich-578	138	22	polymannuronate	polymannuronate	NOUN
biomedich-578	138	23	(	(	PUNCT
biomedich-578	138	24	polysaccharide	polysaccharide	NOUN
biomedich-578	138	25	)	)	PUNCT
biomedich-578	138	26	.	.	PUNCT
biomedich-578	139	1	an	an	DET
biomedich-578	139	2	alginate	alginate	NOUN
biomedich-578	139	3	-	-	PUNCT
biomedich-578	139	4	derived	derive	VERB
biomedich-578	139	5	polymannuronate	polymannuronate	NOUN
biomedich-578	139	6	,	,	PUNCT
biomedich-578	139	7	namely	namely	ADV
biomedich-578	139	8	seleno	seleno	NOUN
biomedich-578	139	9	-	-	PUNCT
biomedich-578	139	10	polymannuronate	polymannuronate	NOUN
biomedich-578	139	11	,	,	PUNCT
biomedich-578	139	12	can	can	AUX
biomedich-578	139	13	inhibit	inhibit	VERB
biomedich-578	139	14	aβ	aβ	PRON
biomedich-578	139	15	aggregation	aggregation	NOUN
biomedich-578	139	16	and	and	CCONJ
biomedich-578	139	17	reduce	reduce	VERB
biomedich-578	139	18	app	app	NOUN
biomedich-578	139	19	and	and	CCONJ
biomedich-578	139	20	bace-1	bace-1	PROPN
biomedich-578	139	21	.	.	PUNCT
biomedich-578	140	1	this	this	PRON
biomedich-578	140	2	demonstrates	demonstrate	VERB
biomedich-578	140	3	that	that	SCONJ
biomedich-578	140	4	products	product	NOUN
biomedich-578	140	5	from	from	ADP
biomedich-578	140	6	these	these	DET
biomedich-578	140	7	mnps	mnps	NOUN
biomedich-578	140	8	have	have	VERB
biomedich-578	140	9	the	the	DET
biomedich-578	140	10	potential	potential	NOUN
biomedich-578	140	11	as	as	SCONJ
biomedich-578	140	12	neuroprotective	neuroprotective	ADJ
biomedich-578	140	13	agents.5,34	agents.5,34	PROPN
biomedich-578	140	14	various	various	ADJ
biomedich-578	140	15	marine	marine	ADJ
biomedich-578	140	16	red	red	ADJ
biomedich-578	140	17	algae	algae	NOUN
biomedich-578	140	18	are	be	AUX
biomedich-578	140	19	known	know	VERB
biomedich-578	140	20	as	as	ADP
biomedich-578	140	21	sources	source	NOUN
biomedich-578	140	22	of	of	ADP
biomedich-578	140	23	homotaurine	homotaurine	NOUN
biomedich-578	140	24	,	,	PUNCT
biomedich-578	140	25	an	an	DET
biomedich-578	140	26	amino	amino	NOUN
biomedich-578	140	27	sulfonate	sulfonate	NOUN
biomedich-578	140	28	that	that	PRON
biomedich-578	140	29	can	can	AUX
biomedich-578	140	30	inhibit	inhibit	VERB
biomedich-578	140	31	aβ	aβ	DET
biomedich-578	140	32	aggregation	aggregation	NOUN
biomedich-578	140	33	and	and	CCONJ
biomedich-578	140	34	oligomerization	oligomerization	NOUN
biomedich-578	140	35	,	,	PUNCT
biomedich-578	140	36	also	also	ADV
biomedich-578	140	37	amyloid	amyloid	VERB
biomedich-578	140	38	fibril	fibril	ADJ
biomedich-578	140	39	deposition.5,12	deposition.5,12	NOUN
biomedich-578	140	40	in	in	ADP
biomedich-578	140	41	addition	addition	NOUN
biomedich-578	140	42	,	,	PUNCT
biomedich-578	140	43	the	the	DET
biomedich-578	140	44	green	green	ADJ
biomedich-578	140	45	alga	alga	ADJ
biomedich-578	140	46	haematococcus	haematococcus	NOUN
biomedich-578	140	47	pluvialis	pluviali	NOUN
biomedich-578	140	48	contains	contain	VERB
biomedich-578	140	49	astaxanthin	astaxanthin	ADJ
biomedich-578	140	50	(	(	PUNCT
biomedich-578	140	51	carotenoid	carotenoid	NOUN
biomedich-578	140	52	)	)	PUNCT
biomedich-578	140	53	,	,	PUNCT
biomedich-578	140	54	which	which	PRON
biomedich-578	140	55	has	have	AUX
biomedich-578	140	56	been	be	AUX
biomedich-578	140	57	used	use	VERB
biomedich-578	140	58	in	in	ADP
biomedich-578	140	59	the	the	DET
biomedich-578	140	60	supplementary	supplementary	ADJ
biomedich-578	140	61	due	due	ADP
biomedich-578	140	62	to	to	ADP
biomedich-578	140	63	its	its	PRON
biomedich-578	140	64	effects	effect	NOUN
biomedich-578	140	65	in	in	ADP
biomedich-578	140	66	reducing	reduce	VERB
biomedich-578	140	67	the	the	DET
biomedich-578	140	68	production	production	NOUN
biomedich-578	140	69	of	of	ADP
biomedich-578	140	70	nf	nf	ADJ
biomedich-578	140	71	-	-	PUNCT
biomedich-578	140	72	κb	κb	NOUN
biomedich-578	140	73	transcription	transcription	NOUN
biomedich-578	140	74	factors	factor	NOUN
biomedich-578	140	75	and	and	CCONJ
biomedich-578	140	76	pro	pro	X
biomedich-578	140	77	438	438	NUM
biomedich-578	140	78	biology	biology	NOUN
biomedich-578	140	79	,	,	PUNCT
biomedich-578	140	80	medicine	medicine	NOUN
biomedich-578	140	81	,	,	PUNCT
biomedich-578	140	82	&	&	CCONJ
biomedich-578	140	83	natural	natural	ADJ
biomedich-578	140	84	product	product	NOUN
biomedich-578	140	85	chemistry	chemistry	NOUN
biomedich-578	140	86	13	13	NUM
biomedich-578	140	87	(	(	PUNCT
biomedich-578	140	88	2	2	NUM
biomedich-578	140	89	)	)	PUNCT
biomedich-578	140	90	,	,	PUNCT
biomedich-578	140	91	2024	2024	NUM
biomedich-578	140	92	:	:	PUNCT
biomedich-578	140	93	433	433	NUM
biomedich-578	140	94	-	-	SYM
biomedich-578	140	95	441	441	NUM
biomedich-578	140	96	inflammatory	inflammatory	ADJ
biomedich-578	140	97	cytokines.5	cytokines.5	NOUN
biomedich-578	140	98	dead	dead	ADJ
biomedich-578	140	99	man	man	NOUN
biomedich-578	140	100	’s	’s	PART
biomedich-578	140	101	finger	finger	NOUN
biomedich-578	140	102	(	(	PUNCT
biomedich-578	140	103	codium	codium	NOUN
biomedich-578	140	104	fragile	fragile	ADJ
biomedich-578	140	105	)	)	PUNCT
biomedich-578	140	106	is	be	AUX
biomedich-578	140	107	a	a	DET
biomedich-578	140	108	green	green	ADJ
biomedich-578	140	109	seaweed	seaweed	NOUN
biomedich-578	140	110	that	that	PRON
biomedich-578	140	111	contains	contain	VERB
biomedich-578	140	112	mannan	mannan	NOUN
biomedich-578	140	113	,	,	PUNCT
biomedich-578	140	114	a	a	DET
biomedich-578	140	115	polysaccharide	polysaccharide	NOUN
biomedich-578	140	116	known	know	VERB
biomedich-578	140	117	to	to	PART
biomedich-578	140	118	inhibit	inhibit	VERB
biomedich-578	140	119	bace-1.5	bace-1.5	NOUN
biomedich-578	140	120	some	some	DET
biomedich-578	140	121	seaweeds	seaweed	NOUN
biomedich-578	140	122	are	be	AUX
biomedich-578	140	123	isolated	isolated	ADJ
biomedich-578	140	124	sources	source	NOUN
biomedich-578	140	125	of	of	ADP
biomedich-578	140	126	betaine	betaine	NOUN
biomedich-578	140	127	,	,	PUNCT
biomedich-578	140	128	which	which	PRON
biomedich-578	140	129	is	be	AUX
biomedich-578	140	130	a	a	DET
biomedich-578	140	131	potent	potent	ADJ
biomedich-578	140	132	antioxidant.32	antioxidant.32	PROPN
biomedich-578	140	133	marine	marine	PROPN
biomedich-578	140	134	microorganism	microorganism	NOUN
biomedich-578	140	135	marine	marine	PROPN
biomedich-578	140	136	fungi	fungus	NOUN
biomedich-578	140	137	are	be	AUX
biomedich-578	140	138	fungi	fungus	NOUN
biomedich-578	140	139	isolated	isolate	VERB
biomedich-578	140	140	from	from	ADP
biomedich-578	140	141	marine	marine	ADJ
biomedich-578	140	142	habitats	habitat	NOUN
biomedich-578	140	143	,	,	PUNCT
biomedich-578	140	144	either	either	CCONJ
biomedich-578	140	145	as	as	ADP
biomedich-578	140	146	obligate	obligate	NOUN
biomedich-578	140	147	microorganisms	microorganism	NOUN
biomedich-578	140	148	or	or	CCONJ
biomedich-578	140	149	as	as	ADP
biomedich-578	140	150	facultative	facultative	ADJ
biomedich-578	140	151	microorganisms	microorganism	NOUN
biomedich-578	140	152	(	(	PUNCT
biomedich-578	140	153	nugraha	nugraha	NOUN
biomedich-578	140	154	et	et	PROPN
biomedich-578	140	155	al	al	PROPN
biomedich-578	140	156	.	.	PROPN
biomedich-578	140	157	,	,	PUNCT
biomedich-578	140	158	2023	2023	NUM
biomedich-578	140	159	)	)	PUNCT
biomedich-578	140	160	.	.	PUNCT
biomedich-578	141	1	streptomyces	streptomyce	NOUN
biomedich-578	141	2	sp	sp	NOUN
biomedich-578	141	3	.	.	PROPN
biomedich-578	141	4	contains	contain	VERB
biomedich-578	141	5	indole	indole	NOUN
biomedich-578	141	6	,	,	PUNCT
biomedich-578	141	7	a	a	DET
biomedich-578	141	8	type	type	NOUN
biomedich-578	141	9	of	of	ADP
biomedich-578	141	10	alkaloid	alkaloid	NOUN
biomedich-578	141	11	that	that	PRON
biomedich-578	141	12	can	can	AUX
biomedich-578	141	13	inhibit	inhibit	VERB
biomedich-578	141	14	the	the	DET
biomedich-578	141	15	formation	formation	NOUN
biomedich-578	141	16	of	of	ADP
biomedich-578	141	17	aβ	aβ	NOUN
biomedich-578	141	18	plaque	plaque	NOUN
biomedich-578	141	19	through	through	ADP
biomedich-578	141	20	the	the	DET
biomedich-578	141	21	activation	activation	NOUN
biomedich-578	141	22	of	of	ADP
biomedich-578	141	23	nrf2	nrf2	PROPN
biomedich-578	141	24	(	(	PUNCT
biomedich-578	141	25	hu	hu	PROPN
biomedich-578	141	26	et	et	PROPN
biomedich-578	141	27	al	al	PROPN
biomedich-578	141	28	.	.	PROPN
biomedich-578	141	29	,	,	PUNCT
biomedich-578	141	30	2023	2023	NUM
biomedich-578	141	31	)	)	PUNCT
biomedich-578	141	32	.	.	PUNCT
biomedich-578	142	1	streptomyces	streptomyce	NOUN
biomedich-578	142	2	caniferus	caniferus	NOUN
biomedich-578	142	3	and	and	CCONJ
biomedich-578	142	4	phylum	phylum	NOUN
biomedich-578	142	5	actinobacteria	actinobacteria	NOUN
biomedich-578	142	6	produce	produce	VERB
biomedich-578	142	7	caniferolide	caniferolide	PROPN
biomedich-578	142	8	a	a	PRON
biomedich-578	142	9	which	which	PRON
biomedich-578	142	10	can	can	AUX
biomedich-578	142	11	reduce	reduce	VERB
biomedich-578	142	12	neuroinflammation	neuroinflammation	NOUN
biomedich-578	142	13	,	,	PUNCT
biomedich-578	142	14	oxidative	oxidative	ADJ
biomedich-578	142	15	stress	stress	NOUN
biomedich-578	142	16	,	,	PUNCT
biomedich-578	142	17	blockage	blockage	NOUN
biomedich-578	142	18	bace-1	bace-1	PROPN
biomedich-578	142	19	,	,	PUNCT
biomedich-578	142	20	inhibit	inhibit	VERB
biomedich-578	142	21	aβ	aβ	NOUN
biomedich-578	142	22	and	and	CCONJ
biomedich-578	142	23	tau	tau	PROPN
biomedich-578	142	24	pathology	pathology	NOUN
biomedich-578	142	25	,	,	PUNCT
biomedich-578	142	26	and	and	CCONJ
biomedich-578	142	27	is	be	AUX
biomedich-578	142	28	referred	refer	VERB
biomedich-578	142	29	to	to	ADP
biomedich-578	142	30	as	as	ADP
biomedich-578	142	31	a	a	DET
biomedich-578	142	32	potential	potential	ADJ
biomedich-578	142	33	compound	compound	NOUN
biomedich-578	142	34	in	in	ADP
biomedich-578	142	35	ad	ad	NOUN
biomedich-578	142	36	therapy	therapy	NOUN
biomedich-578	142	37	(	(	PUNCT
biomedich-578	142	38	carroll	carroll	PROPN
biomedich-578	142	39	et	et	PROPN
biomedich-578	142	40	al	al	PROPN
biomedich-578	142	41	,	,	PUNCT
biomedich-578	142	42	2021	2021	NUM
biomedich-578	142	43	;	;	PUNCT
biomedich-578	142	44	hu	hu	PROPN
biomedich-578	142	45	et	et	PROPN
biomedich-578	142	46	al	al	PROPN
biomedich-578	142	47	.	.	PROPN
biomedich-578	142	48	,	,	PUNCT
biomedich-578	142	49	2023	2023	NUM
biomedich-578	142	50	)	)	PUNCT
biomedich-578	142	51	.	.	PUNCT
biomedich-578	143	1	furthermore	furthermore	ADV
biomedich-578	143	2	,	,	PUNCT
biomedich-578	143	3	streptomyces	streptomyce	NOUN
biomedich-578	143	4	-	-	PUNCT
biomedich-578	143	5	derived	derive	VERB
biomedich-578	143	6	compounds	compound	NOUN
biomedich-578	143	7	anhydroexfoliamycin	anhydroexfoliamycin	PRON
biomedich-578	143	8	and	and	CCONJ
biomedich-578	143	9	undecylprodigiosin	undecylprodigiosin	NOUN
biomedich-578	143	10	are	be	AUX
biomedich-578	143	11	nrf2	nrf2	NOUN
biomedich-578	143	12	inducers	inducer	NOUN
biomedich-578	143	13	,	,	PUNCT
biomedich-578	143	14	thus	thus	ADV
biomedich-578	143	15	able	able	ADJ
biomedich-578	143	16	to	to	PART
biomedich-578	143	17	suppress	suppress	VERB
biomedich-578	143	18	oxidative	oxidative	ADJ
biomedich-578	143	19	stress	stress	NOUN
biomedich-578	143	20	.	.	PUNCT
biomedich-578	144	1	anhydroexfoliamycin	anhydroexfoliamycin	PROPN
biomedich-578	144	2	also	also	ADV
biomedich-578	144	3	significantly	significantly	ADV
biomedich-578	144	4	suppresses	suppress	VERB
biomedich-578	144	5	gsk-3β	gsk-3β	PROPN
biomedich-578	144	6	and	and	CCONJ
biomedich-578	144	7	reduces	reduce	VERB
biomedich-578	144	8	tau	tau	PROPN
biomedich-578	144	9	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	144	10	(	(	PUNCT
biomedich-578	144	11	kabir	kabir	PROPN
biomedich-578	144	12	et	et	PROPN
biomedich-578	144	13	al	al	PROPN
biomedich-578	144	14	.	.	PROPN
biomedich-578	144	15	,	,	PUNCT
biomedich-578	144	16	2021	2021	NUM
biomedich-578	144	17	)	)	PUNCT
biomedich-578	144	18	.	.	PUNCT
biomedich-578	145	1	rifamycin	rifamycin	PROPN
biomedich-578	145	2	from	from	ADP
biomedich-578	145	3	the	the	DET
biomedich-578	145	4	marine	marine	ADJ
biomedich-578	145	5	bacterium	bacterium	NOUN
biomedich-578	145	6	salinispora	salinispora	PROPN
biomedich-578	145	7	,	,	PUNCT
biomedich-578	145	8	extracted	extract	VERB
biomedich-578	145	9	from	from	ADP
biomedich-578	145	10	the	the	DET
biomedich-578	145	11	marine	marine	ADJ
biomedich-578	145	12	sponge	sponge	NOUN
biomedich-578	145	13	pseudoceratina	pseudoceratina	PROPN
biomedich-578	145	14	clavate	clavate	NOUN
biomedich-578	145	15	,	,	PUNCT
biomedich-578	145	16	exhibits	exhibit	VERB
biomedich-578	145	17	neuroinflammatory	neuroinflammatory	ADJ
biomedich-578	145	18	activity	activity	NOUN
biomedich-578	145	19	and	and	CCONJ
biomedich-578	145	20	potential	potential	ADJ
biomedich-578	145	21	antioxidant	antioxidant	ADJ
biomedich-578	145	22	activity	activity	NOUN
biomedich-578	145	23	in	in	ADP
biomedich-578	145	24	inhibiting	inhibit	VERB
biomedich-578	145	25	the	the	DET
biomedich-578	145	26	production	production	NOUN
biomedich-578	145	27	,	,	PUNCT
biomedich-578	145	28	aggregation	aggregation	NOUN
biomedich-578	145	29	,	,	PUNCT
biomedich-578	145	30	and	and	CCONJ
biomedich-578	145	31	fibrillation	fibrillation	NOUN
biomedich-578	145	32	of	of	ADP
biomedich-578	145	33	aβ	aβ	NOUN
biomedich-578	145	34	,	,	PUNCT
biomedich-578	145	35	including	include	VERB
biomedich-578	145	36	increasing	increase	VERB
biomedich-578	145	37	aβ	aβ	PRON
biomedich-578	145	38	clearance	clearance	NOUN
biomedich-578	145	39	(	(	PUNCT
biomedich-578	145	40	kabir	kabir	PROPN
biomedich-578	145	41	et	et	PROPN
biomedich-578	145	42	al	al	PROPN
biomedich-578	145	43	.	.	PROPN
biomedich-578	145	44	,	,	PUNCT
biomedich-578	145	45	2021	2021	NUM
biomedich-578	145	46	)	)	PUNCT
biomedich-578	145	47	.	.	PUNCT
biomedich-578	146	1	marine	marine	PROPN
biomedich-578	146	2	dinoflagellate	dinoflagellate	PROPN
biomedich-578	146	3	alexandrium	alexandrium	PROPN
biomedich-578	146	4	ostenfeldii	ostenfeldii	NOUN
biomedich-578	146	5	contains	contain	VERB
biomedich-578	146	6	13	13	NUM
biomedich-578	146	7	-	-	PUNCT
biomedich-578	146	8	desmethyl	desmethyl	NOUN
biomedich-578	146	9	spirolide	spirolide	NOUN
biomedich-578	146	10	-	-	PUNCT
biomedich-578	146	11	c	c	NOUN
biomedich-578	146	12	,	,	PUNCT
biomedich-578	146	13	which	which	PRON
biomedich-578	146	14	influences	influence	VERB
biomedich-578	146	15	tau	tau	PROPN
biomedich-578	146	16	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	146	17	by	by	ADP
biomedich-578	146	18	intervening	intervene	VERB
biomedich-578	146	19	in	in	ADP
biomedich-578	146	20	gsk-3β	gsk-3β	PROPN
biomedich-578	146	21	and	and	CCONJ
biomedich-578	146	22	aβ	aβ	ADP
biomedich-578	146	23	accumulation	accumulation	NOUN
biomedich-578	146	24	,	,	PUNCT
biomedich-578	146	25	especially	especially	ADV
biomedich-578	146	26	within	within	ADP
biomedich-578	146	27	cells	cell	NOUN
biomedich-578	146	28	(	(	PUNCT
biomedich-578	146	29	kabir	kabir	PROPN
biomedich-578	146	30	et	et	PROPN
biomedich-578	146	31	al	al	PROPN
biomedich-578	146	32	.	.	PROPN
biomedich-578	146	33	,	,	PUNCT
biomedich-578	146	34	2021	2021	NUM
biomedich-578	146	35	)	)	PUNCT
biomedich-578	146	36	.	.	PUNCT
biomedich-578	147	1	meanwhile	meanwhile	ADV
biomedich-578	147	2	,	,	PUNCT
biomedich-578	147	3	some	some	DET
biomedich-578	147	4	dinoflagellate	dinoflagellate	ADJ
biomedich-578	147	5	species	specie	NOUN
biomedich-578	147	6	are	be	AUX
biomedich-578	147	7	known	know	VERB
biomedich-578	147	8	to	to	PART
biomedich-578	147	9	produce	produce	VERB
biomedich-578	147	10	compounds	compound	NOUN
biomedich-578	147	11	that	that	PRON
biomedich-578	147	12	are	be	AUX
biomedich-578	147	13	potent	potent	ADJ
biomedich-578	147	14	in	in	ADP
biomedich-578	147	15	reducing	reduce	VERB
biomedich-578	147	16	aβ	aβ	PRON
biomedich-578	147	17	plaques	plaque	NOUN
biomedich-578	147	18	and	and	CCONJ
biomedich-578	147	19	tau	tau	PROPN
biomedich-578	147	20	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	147	21	.	.	PUNCT
biomedich-578	148	1	protoceratium	protoceratium	NOUN
biomedich-578	148	2	reticulatum	reticulatum	PROPN
biomedich-578	148	3	,	,	PUNCT
biomedich-578	148	4	lingulodinium	lingulodinium	ADJ
biomedich-578	148	5	polyedrum	polyedrum	NOUN
biomedich-578	148	6	,	,	PUNCT
biomedich-578	148	7	and	and	CCONJ
biomedich-578	148	8	gonyaulax	gonyaulax	PROPN
biomedich-578	148	9	spinifera	spinifera	NOUN
biomedich-578	148	10	are	be	AUX
biomedich-578	148	11	known	know	VERB
biomedich-578	148	12	to	to	PART
biomedich-578	148	13	produce	produce	VERB
biomedich-578	148	14	yessotoxins	yessotoxin	NOUN
biomedich-578	148	15	,	,	PUNCT
biomedich-578	148	16	polyether	polyether	NOUN
biomedich-578	148	17	sulfate	sulfate	NOUN
biomedich-578	148	18	compounds	compound	NOUN
biomedich-578	148	19	that	that	PRON
biomedich-578	148	20	can	can	AUX
biomedich-578	148	21	reduce	reduce	VERB
biomedich-578	148	22	hyperphosphorylated	hyperphosphorylated	ADJ
biomedich-578	148	23	tau	tau	PROPN
biomedich-578	148	24	and	and	CCONJ
biomedich-578	148	25	aβ	aβ	ADP
biomedich-578	148	26	accumulation	accumulation	NOUN
biomedich-578	148	27	through	through	ADP
biomedich-578	148	28	pkc	pkc	NOUN
biomedich-578	148	29	activation	activation	NOUN
biomedich-578	148	30	.	.	PUNCT
biomedich-578	149	1	karenia	karenia	PROPN
biomedich-578	149	2	selliformis	selliformis	PROPN
biomedich-578	149	3	also	also	ADV
biomedich-578	149	4	produces	produce	VERB
biomedich-578	149	5	the	the	DET
biomedich-578	149	6	toxin	toxin	NOUN
biomedich-578	149	7	gymnodimine	gymnodimine	NOUN
biomedich-578	149	8	,	,	PUNCT
biomedich-578	149	9	which	which	PRON
biomedich-578	149	10	can	can	AUX
biomedich-578	149	11	reduce	reduce	VERB
biomedich-578	149	12	intracellular	intracellular	NOUN
biomedich-578	149	13	aβ	aβ	NOUN
biomedich-578	149	14	accumulation	accumulation	NOUN
biomedich-578	149	15	and	and	CCONJ
biomedich-578	149	16	inhibit	inhibit	VERB
biomedich-578	149	17	gsk-3	gsk-3	NOUN
biomedich-578	149	18	.	.	PUNCT
biomedich-578	150	1	additionally	additionally	ADV
biomedich-578	150	2	,	,	PUNCT
biomedich-578	150	3	gambierol	gambierol	PROPN
biomedich-578	150	4	obtained	obtain	VERB
biomedich-578	150	5	from	from	ADP
biomedich-578	150	6	gambierdiscus	gambierdiscus	NOUN
biomedich-578	150	7	toxicus	toxicus	NOUN
biomedich-578	150	8	can	can	AUX
biomedich-578	150	9	reduce	reduce	VERB
biomedich-578	150	10	the	the	DET
biomedich-578	150	11	levels	level	NOUN
biomedich-578	150	12	of	of	ADP
biomedich-578	150	13	aβ1	aβ1	NOUN
biomedich-578	150	14	-	-	PUNCT
biomedich-578	150	15	42	42	NUM
biomedich-578	150	16	,	,	PUNCT
biomedich-578	150	17	inhibit	inhibit	VERB
biomedich-578	150	18	bace-1	bace-1	PROPN
biomedich-578	150	19	,	,	PUNCT
biomedich-578	150	20	and	and	CCONJ
biomedich-578	150	21	increase	increase	VERB
biomedich-578	150	22	gsk-3β	gsk-3β	NOUN
biomedich-578	150	23	inactivation	inactivation	NOUN
biomedich-578	150	24	(	(	PUNCT
biomedich-578	150	25	botelho	botelho	NOUN
biomedich-578	150	26	et	et	PROPN
biomedich-578	150	27	al	al	PROPN
biomedich-578	150	28	.	.	PROPN
biomedich-578	150	29	,	,	PUNCT
biomedich-578	150	30	2022	2022	NUM
biomedich-578	150	31	)	)	PUNCT
biomedich-578	150	32	.	.	PUNCT
biomedich-578	151	1	microalgae	microalgae	NOUN
biomedich-578	151	2	have	have	VERB
biomedich-578	151	3	several	several	ADJ
biomedich-578	151	4	types	type	NOUN
biomedich-578	151	5	of	of	ADP
biomedich-578	151	6	polyunsaturated	polyunsaturated	ADJ
biomedich-578	151	7	fatty	fatty	NOUN
biomedich-578	151	8	acids	acid	NOUN
biomedich-578	151	9	such	such	ADJ
biomedich-578	151	10	as	as	ADP
biomedich-578	151	11	dha	dha	PROPN
biomedich-578	151	12	,	,	PUNCT
biomedich-578	151	13	eicosatetraenoic	eicosatetraenoic	ADJ
biomedich-578	151	14	acid	acid	NOUN
biomedich-578	151	15	,	,	PUNCT
biomedich-578	151	16	αlinolenic	αlinolenic	ADJ
biomedich-578	151	17	acid	acid	NOUN
biomedich-578	151	18	,	,	PUNCT
biomedich-578	151	19	arachidonic	arachidonic	ADJ
biomedich-578	151	20	acid	acid	NOUN
biomedich-578	151	21	,	,	PUNCT
biomedich-578	151	22	linoleic	linoleic	ADJ
biomedich-578	151	23	acid	acid	NOUN
biomedich-578	151	24	,	,	PUNCT
biomedich-578	151	25	and	and	CCONJ
biomedich-578	151	26	oleic	oleic	ADV
biomedich-578	151	27	acid	acid	PROPN
biomedich-578	151	28	,	,	PUNCT
biomedich-578	151	29	which	which	PRON
biomedich-578	151	30	are	be	AUX
biomedich-578	151	31	known	know	VERB
biomedich-578	151	32	to	to	PART
biomedich-578	151	33	inhibit	inhibit	VERB
biomedich-578	151	34	aβ-40	aβ-40	PRON
biomedich-578	151	35	and	and	CCONJ
biomedich-578	151	36	aβ-42	aβ-42	ADJ
biomedich-578	151	37	fibrillogenesis	fibrillogenesis	NOUN
biomedich-578	151	38	,	,	PUNCT
biomedich-578	151	39	thus	thus	ADV
biomedich-578	151	40	having	have	VERB
biomedich-578	151	41	anti	anti	ADJ
biomedich-578	151	42	-	-	ADJ
biomedich-578	151	43	aggregation	aggregation	ADJ
biomedich-578	151	44	effects	effect	NOUN
biomedich-578	151	45	(	(	PUNCT
biomedich-578	151	46	shatshat	shatshat	INTJ
biomedich-578	151	47	et	et	PROPN
biomedich-578	151	48	al	al	PROPN
biomedich-578	151	49	.	.	PROPN
biomedich-578	151	50	,	,	PUNCT
biomedich-578	151	51	2019	2019	NUM
biomedich-578	151	52	)	)	PUNCT
biomedich-578	151	53	.	.	PUNCT
biomedich-578	152	1	the	the	DET
biomedich-578	152	2	dha	dha	PROPN
biomedich-578	152	3	can	can	AUX
biomedich-578	152	4	reduce	reduce	VERB
biomedich-578	152	5	aβ	aβ	ADP
biomedich-578	152	6	deposition	deposition	NOUN
biomedich-578	152	7	,	,	PUNCT
biomedich-578	152	8	tau	tau	NOUN
biomedich-578	152	9	phosphorylation	phosphorylation	NOUN
biomedich-578	152	10	,	,	PUNCT
biomedich-578	152	11	and	and	CCONJ
biomedich-578	152	12	bace-1	bace-1	PROPN
biomedich-578	152	13	also	also	ADV
biomedich-578	152	14	γsecretase	γsecretase	ADJ
biomedich-578	152	15	activity	activity	NOUN
biomedich-578	152	16	.	.	PUNCT
biomedich-578	153	1	neuroprotectin	neuroprotectin	PROPN
biomedich-578	153	2	d1	d1	PROPN
biomedich-578	153	3	is	be	AUX
biomedich-578	153	4	a	a	DET
biomedich-578	153	5	derivative	derivative	NOUN
biomedich-578	153	6	of	of	ADP
biomedich-578	153	7	dha	dha	NOUN
biomedich-578	153	8	that	that	PRON
biomedich-578	153	9	has	have	VERB
biomedich-578	153	10	strong	strong	ADJ
biomedich-578	153	11	anti	anti	ADJ
biomedich-578	153	12	-	-	ADJ
biomedich-578	153	13	inflammatory	inflammatory	ADJ
biomedich-578	153	14	effects	effect	NOUN
biomedich-578	153	15	through	through	ADP
biomedich-578	153	16	the	the	DET
biomedich-578	153	17	inhibition	inhibition	NOUN
biomedich-578	153	18	of	of	ADP
biomedich-578	153	19	proinflammatory	proinflammatory	ADJ
biomedich-578	153	20	cytokines	cytokine	NOUN
biomedich-578	153	21	,	,	PUNCT
biomedich-578	153	22	antiamyloidogenic	antiamyloidogenic	ADJ
biomedich-578	153	23	effects	effect	NOUN
biomedich-578	153	24	through	through	ADP
biomedich-578	153	25	the	the	DET
biomedich-578	153	26	activation	activation	NOUN
biomedich-578	153	27	of	of	ADP
biomedich-578	153	28	αsecretase	αsecretase	NOUN
biomedich-578	153	29	and	and	CCONJ
biomedich-578	153	30	downregulation	downregulation	NOUN
biomedich-578	153	31	of	of	ADP
biomedich-578	153	32	bace-1	bace-1	PROPN
biomedich-578	153	33	,	,	PUNCT
biomedich-578	153	34	and	and	CCONJ
biomedich-578	153	35	antiapoptotic	antiapoptotic	ADJ
biomedich-578	153	36	effects	effect	NOUN
biomedich-578	153	37	(	(	PUNCT
biomedich-578	153	38	martins	martin	NOUN
biomedich-578	153	39	et	et	NOUN
biomedich-578	153	40	al	al	PROPN
biomedich-578	153	41	.	.	PROPN
biomedich-578	153	42	,	,	PUNCT
biomedich-578	153	43	2020	2020	NUM
biomedich-578	153	44	)	)	PUNCT
biomedich-578	153	45	.	.	PUNCT
biomedich-578	154	1	table	table	NOUN
biomedich-578	154	2	1	1	NUM
biomedich-578	154	3	.	.	PUNCT
biomedich-578	155	1	mnps	mnps	PROPN
biomedich-578	155	2	and	and	CCONJ
biomedich-578	155	3	their	their	PRON
biomedich-578	155	4	multitarget	multitarget	NOUN
biomedich-578	155	5	prospects	prospect	NOUN
biomedich-578	155	6	in	in	ADP
biomedich-578	155	7	ad	ad	NOUN
biomedich-578	155	8	pathology	pathology	NOUN
biomedich-578	155	9	.	.	PUNCT
biomedich-578	156	1	source	source	NOUN
biomedich-578	156	2	species	specie	NOUN
biomedich-578	156	3	bioactive	bioactive	VERB
biomedich-578	156	4	compoud	compoud	PROPN
biomedich-578	156	5	site	site	NOUN
biomedich-578	156	6	of	of	ADP
biomedich-578	156	7	action	action	NOUN
biomedich-578	156	8	marine	marine	NOUN
biomedich-578	156	9	vertebrae	vertebrae	NOUN
biomedich-578	156	10	fishes	fish	VERB
biomedich-578	156	11	blackmouth	blackmouth	PROPN
biomedich-578	156	12	catshark	catshark	NOUN
biomedich-578	156	13	(	(	PUNCT
biomedich-578	156	14	galeus	galeus	NOUN
biomedich-578	156	15	melastomus	melastomus	NOUN
biomedich-578	156	16	)	)	PUNCT
biomedich-578	156	17	the	the	DET
biomedich-578	156	18	brown	brown	ADJ
biomedich-578	156	19	meagre/	meagre/	PROPN
biomedich-578	156	20	corb	corb	NOUN
biomedich-578	156	21	(	(	PUNCT
biomedich-578	156	22	sciaena	sciaena	PROPN
biomedich-578	156	23	umbra	umbra	PROPN
biomedich-578	156	24	)	)	PUNCT
biomedich-578	156	25	chondroitin	chondroitin	NOUN
biomedich-578	156	26	sulfate	sulfate	NOUN
biomedich-578	156	27	(	(	PUNCT
biomedich-578	156	28	glycosaminoglycans	glycosaminoglycan	NOUN
biomedich-578	156	29	)	)	PUNCT
biomedich-578	156	30	combat	combat	NOUN
biomedich-578	156	31	toxicity	toxicity	NOUN
biomedich-578	156	32	caused	cause	VERB
biomedich-578	156	33	by	by	ADP
biomedich-578	156	34	ages	age	NOUN
biomedich-578	156	35	impact	impact	VERB
biomedich-578	156	36	aβ	aβ	DET
biomedich-578	156	37	aggregation	aggregation	NOUN
biomedich-578	156	38	oxidative	oxidative	ADJ
biomedich-578	156	39	stress	stress	NOUN
biomedich-578	156	40	neuroinflammation	neuroinflammation	NOUN
biomedich-578	156	41	cod	cod	NOUN
biomedich-578	156	42	fish	fish	NOUN
biomedich-578	156	43	(	(	PUNCT
biomedich-578	156	44	gadus	gadus	PROPN
biomedich-578	156	45	morrhua	morrhua	PROPN
biomedich-578	156	46	l	l	PROPN
biomedich-578	156	47	)	)	PUNCT
biomedich-578	156	48	ω-3	ω-3	NOUN
biomedich-578	157	1	fatty	fatty	NOUN
biomedich-578	157	2	acids	acid	NOUN
biomedich-578	157	3	increase	increase	VERB
biomedich-578	157	4	aβ	aβ	DET
biomedich-578	157	5	degradation	degradation	NOUN
biomedich-578	157	6	and	and	CCONJ
biomedich-578	157	7	clearance	clearance	NOUN
biomedich-578	157	8	marine	marine	ADJ
biomedich-578	157	9	invertebrae	invertebrae	NOUN
biomedich-578	157	10	sponges	sponge	NOUN
biomedich-578	157	11	spongionella	spongionella	NOUN
biomedich-578	157	12	gracilis	gracilis	PROPN
biomedich-578	157	13	gracilin	gracilin	PROPN
biomedich-578	157	14	(	(	PUNCT
biomedich-578	157	15	diterpenoid	diterpenoid	ADJ
biomedich-578	157	16	)	)	PUNCT
biomedich-578	157	17	inhibit	inhibit	VERB
biomedich-578	157	18	bace-1	bace-1	PROPN
biomedich-578	157	19	induction	induction	NOUN
biomedich-578	157	20	nrf2	nrf2	NOUN
biomedich-578	157	21	anti	anti	ADJ
biomedich-578	157	22	-	-	ADJ
biomedich-578	157	23	inflammatory	inflammatory	ADJ
biomedich-578	157	24	and	and	CCONJ
biomedich-578	157	25	antioxidant	antioxidant	ADJ
biomedich-578	157	26	effects	effect	NOUN
biomedich-578	157	27	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	157	28	of	of	ADP
biomedich-578	157	29	tau	tau	PROPN
biomedich-578	157	30	haliclona	haliclona	PROPN
biomedich-578	157	31	sp	sp	PROPN
biomedich-578	157	32	.	.	PROPN
biomedich-578	157	33	acanthostrongylophora	acanthostrongylophora	PROPN
biomedich-578	157	34	manzamine	manzamine	PROPN
biomedich-578	157	35	(	(	PUNCT
biomedich-578	157	36	alkaloid	alkaloid	ADJ
biomedich-578	157	37	)	)	PUNCT
biomedich-578	157	38	inhibit	inhibit	VERB
biomedich-578	157	39	gsk3	gsk3	PROPN
biomedich-578	157	40	reduce	reduce	VERB
biomedich-578	157	41	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	157	42	of	of	ADP
biomedich-578	157	43	tau	tau	PROPN
biomedich-578	157	44	fascaplysinopsis	fascaplysinopsis	NOUN
biomedich-578	157	45	bergquist	bergquist	NOUN
biomedich-578	157	46	sp	sp	ADP
biomedich-578	157	47	fascaplysin	fascaplysin	PROPN
biomedich-578	157	48	(	(	PUNCT
biomedich-578	157	49	alkaloid	alkaloid	NOUN
biomedich-578	157	50	)	)	PUNCT
biomedich-578	157	51	increase	increase	VERB
biomedich-578	157	52	aβ	aβ	PRON
biomedich-578	157	53	clearance	clearance	NOUN
biomedich-578	157	54	9	9	NUM
biomedich-578	157	55	-	-	PUNCT
biomedich-578	157	56	methylfascaplysin	methylfascaplysin	NOUN
biomedich-578	157	57	(	(	PUNCT
biomedich-578	157	58	synthetic	synthetic	ADJ
biomedich-578	157	59	derivate	derivate	NOUN
biomedich-578	157	60	)	)	PUNCT
biomedich-578	157	61	inhibit	inhibit	VERB
biomedich-578	157	62	aβ	aβ	DET
biomedich-578	157	63	peptide	peptide	NOUN
biomedich-578	157	64	formation	formation	NOUN
biomedich-578	157	65	,	,	PUNCT
biomedich-578	157	66	aβ	aβ	DET
biomedich-578	157	67	fibrillation	fibrillation	NOUN
biomedich-578	157	68	and	and	CCONJ
biomedich-578	157	69	ache	ache	ADV
biomedich-578	157	70	activate	activate	VERB
biomedich-578	157	71	antioxidant	antioxidant	ADJ
biomedich-578	157	72	enzymes	enzyme	NOUN
biomedich-578	157	73	reduce	reduce	VERB
biomedich-578	157	74	neuroinflammation	neuroinflammation	NOUN
biomedich-578	157	75	decrease	decrease	NOUN
biomedich-578	157	76	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	157	77	of	of	ADP
biomedich-578	157	78	tau	tau	PROPN
biomedich-578	157	79	spongia	spongia	PROPN
biomedich-578	157	80	sp	sp	PROPN
biomedich-578	157	81	.	.	PROPN
biomedich-578	157	82	dictyostatine	dictyostatine	PROPN
biomedich-578	157	83	(	(	PUNCT
biomedich-578	157	84	macrolide	macrolide	ADV
biomedich-578	157	85	)	)	PUNCT
biomedich-578	157	86	reduce	reduce	VERB
biomedich-578	157	87	tau	tau	PROPN
biomedich-578	157	88	pathology	pathology	PROPN
biomedich-578	157	89	haliclona	haliclona	PROPN
biomedich-578	157	90	moorei	moorei	PROPN
biomedich-578	157	91	anabasaine	anabasaine	NOUN
biomedich-578	157	92	(	(	PUNCT
biomedich-578	157	93	alkaloid	alkaloid	NOUN
biomedich-578	157	94	)	)	PUNCT
biomedich-578	157	95	inhibit	inhibit	VERB
biomedich-578	157	96	apoptosis	apoptosis	NOUN
biomedich-578	157	97	and	and	CCONJ
biomedich-578	157	98	necrosis	necrosis	NOUN
biomedich-578	157	99	of	of	ADP
biomedich-578	157	100	neurons	neuron	NOUN
biomedich-578	157	101	gts-21	gts-21	PROPN
biomedich-578	157	102	(	(	PUNCT
biomedich-578	157	103	nicotine	nicotine	NOUN
biomedich-578	157	104	reduce	reduce	VERB
biomedich-578	157	105	aβ	aβ	PRON
biomedich-578	157	106	setiawan	setiawan	PROPN
biomedich-578	157	107	et	et	PROPN
biomedich-578	157	108	al	al	PROPN
biomedich-578	157	109	.	.	PROPN
biomedich-578	157	110	–	–	PUNCT
biomedich-578	157	111	physicochemical	physicochemical	ADJ
biomedich-578	157	112	candy	candy	NOUN
biomedich-578	157	113	cinnamon	cinnamon	NOUN
biomedich-578	157	114	seaweed	seaweed	NOUN
biomedich-578	157	115	carrageenan	carrageenan	NOUN
biomedich-578	157	116	.	.	PUNCT
biomedich-578	158	1	439	439	NUM
biomedich-578	158	2	analog	analog	NOUN
biomedich-578	158	3	)	)	PUNCT
biomedich-578	158	4	inhibit	inhibit	VERB
biomedich-578	158	5	γ	γ	PROPN
biomedich-578	158	6	-	-	ADJ
biomedich-578	158	7	secretase	secretase	NOUN
biomedich-578	158	8	promote	promote	VERB
biomedich-578	158	9	aβ	aβ	DET
biomedich-578	158	10	clearance	clearance	NOUN
biomedich-578	158	11	tunicate	tunicate	NOUN
biomedich-578	158	12	aplidium	aplidium	NOUN
biomedich-578	158	13	conicum	conicum	PROPN
biomedich-578	158	14	anabasaine	anabasaine	NOUN
biomedich-578	158	15	(	(	PUNCT
biomedich-578	158	16	alkaloid	alkaloid	NOUN
biomedich-578	158	17	)	)	PUNCT
biomedich-578	158	18	inhibit	inhibit	VERB
biomedich-578	158	19	apoptosis	apoptosis	NOUN
biomedich-578	158	20	and	and	CCONJ
biomedich-578	158	21	necrosis	necrosis	NOUN
biomedich-578	158	22	of	of	ADP
biomedich-578	158	23	neurons	neuron	NOUN
biomedich-578	158	24	ascidian	ascidian	ADJ
biomedich-578	158	25	styela	styela	NOUN
biomedich-578	158	26	plicata	plicata	NOUN
biomedich-578	158	27	heparan	heparan	ADJ
biomedich-578	158	28	sulfate	sulfate	NOUN
biomedich-578	158	29	(	(	PUNCT
biomedich-578	158	30	natural	natural	ADJ
biomedich-578	158	31	glycosaminoglicans	glycosaminoglican	NOUN
biomedich-578	158	32	)	)	PUNCT
biomedich-578	158	33	reduce	reduce	VERB
biomedich-578	158	34	aβ	aβ	PRON
biomedich-578	158	35	clams	clams	NOUN
biomedich-578	158	36	anomalocardia	anomalocardia	NOUN
biomedich-578	158	37	brasiliana	brasiliana	PROPN
biomedich-578	158	38	tivela	tivela	PROPN
biomedich-578	158	39	mactroides	mactroide	NOUN
biomedich-578	158	40	donax	donax	VERB
biomedich-578	158	41	striatus	striatus	NOUN
biomedich-578	158	42	tapes	tape	NOUN
biomedich-578	158	43	phlippinarum	phlippinarum	PROPN
biomedich-578	158	44	scallop	scallop	PROPN
biomedich-578	158	45	nodipecten	nodipecten	VERB
biomedich-578	158	46	nodosus	nodosus	PROPN
biomedich-578	158	47	sand	sand	NOUN
biomedich-578	158	48	dollar	dollar	NOUN
biomedich-578	158	49	mellita	mellita	NOUN
biomedich-578	158	50	quinquisperforata	quinquisperforata	PROPN
biomedich-578	158	51	crabs	crab	NOUN
biomedich-578	158	52	goniopsis	goniopsis	NOUN
biomedich-578	158	53	cruentata	cruentata	VERB
biomedich-578	158	54	ucides	ucides	PROPN
biomedich-578	158	55	cordatus	cordatus	PROPN
biomedich-578	158	56	cockle	cockle	PROPN
biomedich-578	158	57	cerastoderma	cerastoderma	PROPN
biomedich-578	158	58	edule	edule	PROPN
biomedich-578	158	59	sea	sea	PROPN
biomedich-578	158	60	cucumber	cucumber	NOUN
biomedich-578	158	61	acaudina	acaudina	NOUN
biomedich-578	158	62	molpadioides	molpadioide	VERB
biomedich-578	158	63	mixture	mixture	NOUN
biomedich-578	158	64	of	of	ADP
biomedich-578	158	65	glycosphingolipids	glycosphingolipid	NOUN
biomedich-578	158	66	reduce	reduce	VERB
biomedich-578	158	67	aβ1–42	aβ1–42	PROPN
biomedich-578	158	68	peptide	peptide	PROPN
biomedich-578	158	69	white	white	PROPN
biomedich-578	158	70	leg	leg	PROPN
biomedich-578	158	71	shrimp	shrimp	PROPN
biomedich-578	158	72	litopenaeus	litopenaeus	PROPN
biomedich-578	158	73	vannamei	vannamei	PROPN
biomedich-578	158	74	natural	natural	ADJ
biomedich-578	158	75	glycosaminoglicans	glycosaminoglican	NOUN
biomedich-578	158	76	:	:	PUNCT
biomedich-578	158	77	chondroitin	chondroitin	NOUN
biomedich-578	158	78	sulphate	sulphate	NOUN
biomedich-578	158	79	heparan	heparan	ADJ
biomedich-578	158	80	sulfate	sulfate	NOUN
biomedich-578	158	81	dermatan	dermatan	PROPN
biomedich-578	158	82	sulphate	sulphate	NOUN
biomedich-578	158	83	inhibit	inhibit	NOUN
biomedich-578	158	84	bace-1	bace-1	PROPN
biomedich-578	158	85	bryozoa	bryozoan	NOUN
biomedich-578	158	86	bugula	bugula	NOUN
biomedich-578	158	87	neritina	neritina	NOUN
biomedich-578	158	88	bryostatin-1	bryostatin-1	NUM
biomedich-578	158	89	(	(	PUNCT
biomedich-578	158	90	macrolide	macrolide	NOUN
biomedich-578	158	91	lactone	lactone	NOUN
biomedich-578	158	92	)	)	PUNCT
biomedich-578	158	93	modulate	modulate	VERB
biomedich-578	158	94	pkcε	pkcε	NOUN
biomedich-578	158	95	degradate	degradate	NOUN
biomedich-578	158	96	aβ	aβ	PRON
biomedich-578	158	97	activate	activate	VERB
biomedich-578	158	98	α	α	PRON
biomedich-578	158	99	-	-	NOUN
biomedich-578	158	100	secretase	secretase	NOUN
biomedich-578	158	101	interfere	interfere	VERB
biomedich-578	158	102	gsk-3β	gsk-3β	PROPN
biomedich-578	158	103	reduce	reduce	VERB
biomedich-578	158	104	tau	tau	PROPN
biomedich-578	158	105	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	158	106	marine	marine	PROPN
biomedich-578	158	107	worm	worm	NOUN
biomedich-578	158	108	nemertines	nemertine	NOUN
biomedich-578	158	109	anabasaine	anabasaine	NOUN
biomedich-578	158	110	stimulate	stimulate	VERB
biomedich-578	158	111	nachr	nachr	PROPN
biomedich-578	158	112	algae/	algae/	NUM
biomedich-578	158	113	seaweed	seaweed	NOUN
biomedich-578	158	114	brown	brown	ADJ
biomedich-578	158	115	algae	algae	NOUN
biomedich-578	158	116	ecklonia	ecklonia	NOUN
biomedich-578	158	117	cava	cava	NOUN
biomedich-578	158	118	fucoidan	fucoidan	PROPN
biomedich-578	158	119	reduce	reduce	VERB
biomedich-578	158	120	aβ	aβ	DET
biomedich-578	158	121	production	production	NOUN
biomedich-578	158	122	reduce	reduce	VERB
biomedich-578	158	123	tau	tau	PROPN
biomedich-578	158	124	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	158	125	reduce	reduce	VERB
biomedich-578	158	126	nfκb	nfκb	NOUN
biomedich-578	158	127	and	and	CCONJ
biomedich-578	158	128	stat3	stat3	NOUN
biomedich-578	158	129	phlorotannin	phlorotannin	NOUN
biomedich-578	158	130	(	(	PUNCT
biomedich-578	158	131	dieckol	dieckol	PROPN
biomedich-578	158	132	,	,	PUNCT
biomedich-578	158	133	eckol	eckol	NOUN
biomedich-578	158	134	,	,	PUNCT
biomedich-578	158	135	and	and	CCONJ
biomedich-578	158	136	8,8′-bieckol	8,8′-bieckol	NUM
biomedich-578	158	137	)	)	PUNCT
biomedich-578	158	138	inhibit	inhibit	NOUN
biomedich-578	158	139	bace-1	bace-1	PROPN
biomedich-578	158	140	inactivate	inactivate	VERB
biomedich-578	158	141	nf	nf	NOUN
biomedich-578	158	142	-	-	PUNCT
biomedich-578	158	143	κb	κb	NOUN
biomedich-578	158	144	inhibit	inhibit	VERB
biomedich-578	158	145	aβ	aβ	DET
biomedich-578	158	146	peptide	peptide	ADJ
biomedich-578	158	147	accumulation	accumulation	NOUN
biomedich-578	158	148	interfere	interfere	VERB
biomedich-578	158	149	aβ	aβ	DET
biomedich-578	158	150	production	production	NOUN
biomedich-578	158	151	ecklonia	ecklonia	NOUN
biomedich-578	158	152	spp	spp	PROPN
biomedich-578	158	153	.	.	PROPN
biomedich-578	159	1	mannuronate	mannuronate	PROPN
biomedich-578	159	2	(	(	PUNCT
biomedich-578	159	3	oligosaccharides	oligosaccharide	NOUN
biomedich-578	159	4	)	)	PUNCT
biomedich-578	159	5	inhibit	inhibit	VERB
biomedich-578	159	6	aβ	aβ	DET
biomedich-578	159	7	aggregation	aggregation	NOUN
biomedich-578	159	8	inhibit	inhibit	NOUN
biomedich-578	159	9	bace-1	bace-1	PROPN
biomedich-578	159	10	production	production	NOUN
biomedich-578	159	11	panida	panida	PROPN
biomedich-578	159	12	australis	australi	VERB
biomedich-578	159	13	sargassum	sargassum	PROPN
biomedich-578	159	14	horridum	horridum	PROPN
biomedich-578	159	15	fucosterol	fucosterol	NOUN
biomedich-578	159	16	(	(	PUNCT
biomedich-578	159	17	sterol	sterol	NOUN
biomedich-578	159	18	)	)	PUNCT
biomedich-578	159	19	prevent	prevent	VERB
biomedich-578	159	20	aβ	aβ	NOUN
biomedich-578	159	21	oligomerization	oligomerization	NOUN
biomedich-578	159	22	anti	anti	ADJ
biomedich-578	159	23	-	-	ADJ
biomedich-578	159	24	inflammatory	inflammatory	ADJ
biomedich-578	159	25	anti	anti	ADJ
biomedich-578	159	26	-	-	ADJ
biomedich-578	159	27	bace1	bace1	ADJ
biomedich-578	159	28	sargassum	sargassum	NOUN
biomedich-578	159	29	siliquastrum	siliquastrum	PROPN
biomedich-578	159	30	fucoxanthin	fucoxanthin	PROPN
biomedich-578	159	31	antioxidant	antioxidant	ADJ
biomedich-578	159	32	anti	anti	ADJ
biomedich-578	159	33	-	-	ADJ
biomedich-578	159	34	inflammatory	inflammatory	ADJ
biomedich-578	159	35	dictyota	dictyota	NOUN
biomedich-578	159	36	coriacea	coriacea	PROPN
biomedich-578	159	37	dictyospiromide	dictyospiromide	ADV
biomedich-578	159	38	(	(	PUNCT
biomedich-578	159	39	diterpenoid	diterpenoid	ADJ
biomedich-578	159	40	-	-	PUNCT
biomedich-578	159	41	maleimide	maleimide	ADJ
biomedich-578	159	42	)	)	PUNCT
biomedich-578	159	43	activate	activate	NOUN
biomedich-578	159	44	of	of	ADP
biomedich-578	159	45	nrf2	nrf2	NOUN
biomedich-578	159	46	/	/	PUNCT
biomedich-578	159	47	are	be	AUX
biomedich-578	159	48	signaling	signal	VERB
biomedich-578	159	49	antioxidant	antioxidant	ADJ
biomedich-578	159	50	cytoprotective	cytoprotective	ADJ
biomedich-578	159	51	dictyopteris	dictyopteris	PROPN
biomedich-578	159	52	spp	spp	PROPN
biomedich-578	159	53	.	.	PUNCT
biomedich-578	160	1	zonarol	zonarol	PROPN
biomedich-578	160	2	antioxidant	antioxidant	PROPN
biomedich-578	160	3	laminaria	laminaria	PROPN
biomedich-578	160	4	hyperborea	hyperborea	PROPN
biomedich-578	160	5	laminaria	laminaria	PROPN
biomedich-578	160	6	digitata	digitata	AUX
biomedich-578	160	7	macrocystis	macrocystis	PROPN
biomedich-578	160	8	pyrifera	pyrifera	PROPN
biomedich-578	160	9	ascophyllum	ascophyllum	PROPN
biomedich-578	160	10	nodosum	nodosum	PROPN
biomedich-578	160	11	laminaria	laminaria	PROPN
biomedich-578	160	12	japonica	japonica	PROPN
biomedich-578	160	13	polymannuronate	polymannuronate	NOUN
biomedich-578	160	14	(	(	PUNCT
biomedich-578	160	15	polysaccharide	polysaccharide	NOUN
biomedich-578	160	16	)	)	PUNCT
biomedich-578	160	17	selenopolymannuronate	selenopolymannuronate	NOUN
biomedich-578	160	18	reduce	reduce	VERB
biomedich-578	160	19	app	app	NOUN
biomedich-578	160	20	inhibit	inhibit	PROPN
biomedich-578	160	21	bace-1	bace-1	PROPN
biomedich-578	160	22	reduce	reduce	VERB
biomedich-578	160	23	aβ	aβ	PRON
biomedich-578	160	24	aggregation	aggregation	NOUN
biomedich-578	160	25	marine	marine	ADJ
biomedich-578	160	26	red	red	PROPN
biomedich-578	160	27	algae	algae	PROPN
biomedich-578	160	28	homotaurine	homotaurine	NOUN
biomedich-578	160	29	(	(	PUNCT
biomedich-578	160	30	amino	amino	NOUN
biomedich-578	160	31	sulfonate	sulfonate	NOUN
biomedich-578	160	32	)	)	PUNCT
biomedich-578	160	33	inhibit	inhibit	VERB
biomedich-578	160	34	aβ	aβ	PRON
biomedich-578	160	35	aggregation	aggregation	NOUN
biomedich-578	160	36	and	and	CCONJ
biomedich-578	160	37	oligomerization	oligomerization	NOUN
biomedich-578	160	38	inhibit	inhibit	NOUN
biomedich-578	160	39	amyloid	amyloid	NOUN
biomedich-578	160	40	fibril	fibril	ADJ
biomedich-578	160	41	deposition	deposition	NOUN
biomedich-578	160	42	green	green	ADJ
biomedich-578	160	43	alga	alga	ADJ
biomedich-578	160	44	haematococcus	haematococcus	NOUN
biomedich-578	160	45	pluvialis	pluviali	NOUN
biomedich-578	160	46	astaxanthin	astaxanthin	NOUN
biomedich-578	160	47	(	(	PUNCT
biomedich-578	160	48	carotenoid	carotenoid	NOUN
biomedich-578	160	49	)	)	PUNCT
biomedich-578	160	50	reduce	reduce	VERB
biomedich-578	160	51	production	production	NOUN
biomedich-578	160	52	of	of	ADP
biomedich-578	160	53	nf	nf	NOUN
biomedich-578	160	54	-	-	PUNCT
biomedich-578	160	55	κb	κb	NOUN
biomedich-578	160	56	and	and	CCONJ
biomedich-578	160	57	proinflammatory	proinflammatory	ADJ
biomedich-578	160	58	cytokines	cytokine	NOUN
biomedich-578	160	59	green	green	ADJ
biomedich-578	160	60	seaweed	seaweed	NOUN
biomedich-578	160	61	dead	dead	ADJ
biomedich-578	160	62	man	man	NOUN
biomedich-578	160	63	’s	’s	PART
biomedich-578	160	64	finger	finger	NOUN
biomedich-578	160	65	(	(	PUNCT
biomedich-578	160	66	codium	codium	NOUN
biomedich-578	160	67	fragile	fragile	ADJ
biomedich-578	160	68	)	)	PUNCT
biomedich-578	160	69	mannan	mannan	NOUN
biomedich-578	160	70	(	(	PUNCT
biomedich-578	160	71	polysaccharide	polysaccharide	NOUN
biomedich-578	160	72	)	)	PUNCT
biomedich-578	160	73	inhibit	inhibit	VERB
biomedich-578	160	74	bace-1	bace-1	PROPN
biomedich-578	160	75	some	some	DET
biomedich-578	160	76	seaweeds	seaweed	VERB
biomedich-578	160	77	betaine	betaine	NOUN
biomedich-578	160	78	potent	potent	ADJ
biomedich-578	160	79	antioxidant	antioxidant	ADJ
biomedich-578	160	80	marine	marine	ADJ
biomedich-578	160	81	microorganism	microorganism	NOUN
biomedich-578	160	82	fungi	fungus	NOUN
biomedich-578	160	83	streptomyces	streptomyce	NOUN
biomedich-578	160	84	sp	sp	NOUN
biomedich-578	160	85	.	.	NOUN
biomedich-578	160	86	indole	indole	NOUN
biomedich-578	160	87	(	(	PUNCT
biomedich-578	160	88	alkaloid	alkaloid	NOUN
biomedich-578	160	89	)	)	PUNCT
biomedich-578	160	90	activate	activate	VERB
biomedich-578	160	91	nrf2	nrf2	PROPN
biomedich-578	160	92	inhibit	inhibit	VERB
biomedich-578	160	93	aβ	aβ	DET
biomedich-578	160	94	plaque	plaque	NOUN
biomedich-578	160	95	formation	formation	NOUN
biomedich-578	160	96	anhydroexfoliamycin	anhydroexfoliamycin	ADV
biomedich-578	160	97	induce	induce	VERB
biomedich-578	160	98	nrf2	nrf2	NOUN
biomedich-578	160	99	suppresses	suppress	VERB
biomedich-578	160	100	gsk-3β	gsk-3β	NOUN
biomedich-578	160	101	reduces	reduce	VERB
biomedich-578	160	102	tau	tau	PROPN
biomedich-578	160	103	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	160	104	undecylprodigiosin	undecylprodigiosin	NOUN
biomedich-578	160	105	induce	induce	VERB
biomedich-578	160	106	nrf2	nrf2	PROPN
biomedich-578	160	107	440	440	NUM
biomedich-578	160	108	biology	biology	NOUN
biomedich-578	160	109	,	,	PUNCT
biomedich-578	160	110	medicine	medicine	NOUN
biomedich-578	160	111	,	,	PUNCT
biomedich-578	160	112	&	&	CCONJ
biomedich-578	160	113	natural	natural	ADJ
biomedich-578	160	114	product	product	NOUN
biomedich-578	160	115	chemistry	chemistry	NOUN
biomedich-578	160	116	13	13	NUM
biomedich-578	160	117	(	(	PUNCT
biomedich-578	160	118	2	2	NUM
biomedich-578	160	119	)	)	PUNCT
biomedich-578	160	120	,	,	PUNCT
biomedich-578	160	121	2024	2024	NUM
biomedich-578	160	122	:	:	PUNCT
biomedich-578	160	123	433	433	NUM
biomedich-578	160	124	-	-	SYM
biomedich-578	160	125	441	441	NUM
biomedich-578	160	126	streptomyces	streptomyce	NOUN
biomedich-578	160	127	caniferus	caniferus	NOUN
biomedich-578	160	128	phylum	phylum	NOUN
biomedich-578	160	129	actinobacteria	actinobacteria	NOUN
biomedich-578	160	130	caniferolide	caniferolide	PROPN
biomedich-578	160	131	a	a	DET
biomedich-578	160	132	reduce	reduce	NOUN
biomedich-578	160	133	neuroinflammation	neuroinflammation	NOUN
biomedich-578	160	134	reduce	reduce	VERB
biomedich-578	160	135	oxidative	oxidative	ADJ
biomedich-578	160	136	stress	stress	NOUN
biomedich-578	160	137	blockage	blockage	NOUN
biomedich-578	160	138	bace-1	bace-1	PROPN
biomedich-578	160	139	inhibit	inhibit	VERB
biomedich-578	161	1	aβ	aβ	NOUN
biomedich-578	162	1	and	and	CCONJ
biomedich-578	162	2	tau	tau	PROPN
biomedich-578	162	3	pathology	pathology	PROPN
biomedich-578	162	4	marine	marine	PROPN
biomedich-578	162	5	bacterium	bacterium	NOUN
biomedich-578	162	6	salinispora	salinispora	NOUN
biomedich-578	162	7	rifamycin	rifamycin	VERB
biomedich-578	162	8	neuroinflammatory	neuroinflammatory	ADJ
biomedich-578	162	9	antioxidant	antioxidant	ADJ
biomedich-578	162	10	inhibit	inhibit	NOUN
biomedich-578	162	11	aβ	aβ	ADP
biomedich-578	162	12	production	production	NOUN
biomedich-578	162	13	,	,	PUNCT
biomedich-578	162	14	aggregation	aggregation	NOUN
biomedich-578	162	15	,	,	PUNCT
biomedich-578	162	16	and	and	CCONJ
biomedich-578	162	17	fibrillation	fibrillation	NOUN
biomedich-578	162	18	increase	increase	NOUN
biomedich-578	162	19	aβ	aβ	PRON
biomedich-578	162	20	clearance	clearance	NOUN
biomedich-578	162	21	dinoflagellate	dinoflagellate	NOUN
biomedich-578	162	22	alexandrium	alexandrium	NOUN
biomedich-578	162	23	ostenfeldii	ostenfeldii	VERB
biomedich-578	163	1	13	13	NUM
biomedich-578	163	2	-	-	PUNCT
biomedich-578	163	3	desmethyl	desmethyl	NOUN
biomedich-578	163	4	spirolide	spirolide	NOUN
biomedich-578	163	5	-	-	PUNCT
biomedich-578	163	6	c	c	NOUN
biomedich-578	163	7	interfere	interfere	VERB
biomedich-578	163	8	gsk-3β	gsk-3β	ADJ
biomedich-578	163	9	influence	influence	NOUN
biomedich-578	163	10	tau	tau	PROPN
biomedich-578	163	11	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	163	12	reduce	reduce	VERB
biomedich-578	163	13	intracelular	intracelular	ADJ
biomedich-578	163	14	aβ	aβ	PRON
biomedich-578	163	15	accumulation	accumulation	NOUN
biomedich-578	163	16	protoceratium	protoceratium	NOUN
biomedich-578	163	17	reticulatum	reticulatum	NOUN
biomedich-578	163	18	lingulodinium	lingulodinium	PROPN
biomedich-578	163	19	polyedrum	polyedrum	PROPN
biomedich-578	163	20	gonyaulax	gonyaulax	PROPN
biomedich-578	163	21	spinifera	spinifera	NOUN
biomedich-578	163	22	yessotoxins	yessotoxin	NOUN
biomedich-578	163	23	(	(	PUNCT
biomedich-578	163	24	polyether	polyether	NOUN
biomedich-578	163	25	sulfate	sulfate	NOUN
biomedich-578	163	26	)	)	PUNCT
biomedich-578	163	27	reduce	reduce	VERB
biomedich-578	163	28	hyperphosphorylated	hyperphosphorylated	ADJ
biomedich-578	163	29	tau	tau	PROPN
biomedich-578	163	30	reduce	reduce	VERB
biomedich-578	163	31	aβ	aβ	PRON
biomedich-578	163	32	accumulation	accumulation	NOUN
biomedich-578	163	33	karenia	karenia	PROPN
biomedich-578	163	34	selliformis	selliformis	PROPN
biomedich-578	163	35	gymnodimine	gymnodimine	PROPN
biomedich-578	163	36	reduce	reduce	VERB
biomedich-578	163	37	intracellular	intracellular	NOUN
biomedich-578	163	38	aβ	aβ	DET
biomedich-578	163	39	accumulation	accumulation	NOUN
biomedich-578	163	40	inhibit	inhibit	VERB
biomedich-578	163	41	gsk-3	gsk-3	NOUN
biomedich-578	163	42	gambierdiscus	gambierdiscus	NOUN
biomedich-578	163	43	toxicus	toxicus	NOUN
biomedich-578	163	44	gambierol	gambierol	NOUN
biomedich-578	163	45	reduce	reduce	VERB
biomedich-578	163	46	aβ1	aβ1	NOUN
biomedich-578	163	47	-	-	PUNCT
biomedich-578	163	48	42	42	NUM
biomedich-578	163	49	inhibit	inhibit	NOUN
biomedich-578	163	50	bace-1	bace-1	PROPN
biomedich-578	163	51	inactivating	inactivate	VERB
biomedich-578	163	52	gsk-3β	gsk-3β	ADJ
biomedich-578	163	53	microalgae	microalgae	NOUN
biomedich-578	163	54	several	several	ADJ
biomedich-578	163	55	species	specie	NOUN
biomedich-578	163	56	dha	dha	PROPN
biomedich-578	163	57	eicosatetraenoic	eicosatetraenoic	PROPN
biomedich-578	163	58	acid	acid	PROPN
biomedich-578	163	59	α	α	PROPN
biomedich-578	163	60	-	-	ADJ
biomedich-578	163	61	linolenic	linolenic	ADJ
biomedich-578	163	62	acid	acid	NOUN
biomedich-578	163	63	arachidonic	arachidonic	ADJ
biomedich-578	163	64	acid	acid	NOUN
biomedich-578	163	65	linoleic	linoleic	NOUN
biomedich-578	163	66	acid	acid	NOUN
biomedich-578	163	67	oleic	oleic	NOUN
biomedich-578	163	68	acid	acid	PROPN
biomedich-578	163	69	inhibit	inhibit	VERB
biomedich-578	163	70	aβ-40	aβ-40	NOUN
biomedich-578	163	71	and	and	CCONJ
biomedich-578	163	72	aβ-42	aβ-42	PRON
biomedich-578	163	73	fibrillogenesis	fibrillogenesis	NOUN
biomedich-578	163	74	anti	anti	ADJ
biomedich-578	163	75	-	-	NOUN
biomedich-578	163	76	aggregation	aggregation	NOUN
biomedich-578	163	77	reduce	reduce	VERB
biomedich-578	163	78	aβ	aβ	DET
biomedich-578	163	79	deposition	deposition	NOUN
biomedich-578	163	80	reduce	reduce	VERB
biomedich-578	163	81	tau	tau	PROPN
biomedich-578	163	82	phosphorylation	phosphorylation	NOUN
biomedich-578	163	83	anti	anti	ADJ
biomedich-578	163	84	-	-	PROPN
biomedich-578	163	85	bace-1	bace-1	PROPN
biomedich-578	163	86	reduce	reduce	VERB
biomedich-578	163	87	γ	γ	NOUN
biomedich-578	163	88	-	-	NOUN
biomedich-578	163	89	secretase	secretase	NOUN
biomedich-578	163	90	neuroprotectin	neuroprotectin	NOUN
biomedich-578	163	91	d1	d1	PROPN
biomedich-578	163	92	(	(	PUNCT
biomedich-578	163	93	dha	dha	PROPN
biomedich-578	163	94	derivate	derivate	NOUN
biomedich-578	163	95	)	)	PUNCT
biomedich-578	163	96	inhibit	inhibit	VERB
biomedich-578	163	97	proinflammatory	proinflammatory	ADJ
biomedich-578	163	98	cytokines	cytokine	NOUN
biomedich-578	163	99	activate	activate	VERB
biomedich-578	163	100	α	α	PRON
biomedich-578	163	101	-	-	ADJ
biomedich-578	163	102	secretase	secretase	ADJ
biomedich-578	163	103	downregulate	downregulate	PROPN
biomedich-578	163	104	bace-1	bace-1	PROPN
biomedich-578	163	105	anti	anti	ADJ
biomedich-578	163	106	-	-	ADJ
biomedich-578	163	107	apoptotic	apoptotic	ADJ
biomedich-578	163	108	conclusions	conclusion	NOUN
biomedich-578	163	109	marine	marine	ADJ
biomedich-578	163	110	natural	natural	ADJ
biomedich-578	163	111	products	product	NOUN
biomedich-578	163	112	from	from	ADP
biomedich-578	163	113	marine	marine	ADJ
biomedich-578	163	114	vertebrates	vertebrate	NOUN
biomedich-578	163	115	,	,	PUNCT
biomedich-578	163	116	marine	marine	ADJ
biomedich-578	163	117	invertebrates	invertebrate	NOUN
biomedich-578	163	118	,	,	PUNCT
biomedich-578	163	119	algae	algae	NOUN
biomedich-578	163	120	/	/	SYM
biomedich-578	163	121	seaweed	seaweed	NOUN
biomedich-578	163	122	,	,	PUNCT
biomedich-578	163	123	and	and	CCONJ
biomedich-578	163	124	marine	marine	ADJ
biomedich-578	163	125	microorganisms	microorganism	NOUN
biomedich-578	163	126	can	can	AUX
biomedich-578	163	127	be	be	AUX
biomedich-578	163	128	utilized	utilize	VERB
biomedich-578	163	129	for	for	ADP
biomedich-578	163	130	their	their	PRON
biomedich-578	163	131	potential	potential	NOUN
biomedich-578	163	132	as	as	SCONJ
biomedich-578	163	133	they	they	PRON
biomedich-578	163	134	can	can	AUX
biomedich-578	163	135	play	play	VERB
biomedich-578	163	136	a	a	DET
biomedich-578	163	137	role	role	NOUN
biomedich-578	163	138	in	in	ADP
biomedich-578	163	139	several	several	ADJ
biomedich-578	163	140	therapeutic	therapeutic	ADJ
biomedich-578	163	141	targets	target	NOUN
biomedich-578	163	142	in	in	ADP
biomedich-578	163	143	ad	ad	NOUN
biomedich-578	163	144	pathology	pathology	NOUN
biomedich-578	163	145	.	.	PUNCT
biomedich-578	164	1	these	these	DET
biomedich-578	164	2	findings	finding	NOUN
biomedich-578	164	3	can	can	AUX
biomedich-578	164	4	be	be	AUX
biomedich-578	164	5	further	far	ADV
biomedich-578	164	6	utilized	utilize	VERB
biomedich-578	164	7	in	in	ADP
biomedich-578	164	8	drug	drug	NOUN
biomedich-578	164	9	discovery	discovery	NOUN
biomedich-578	164	10	and	and	CCONJ
biomedich-578	164	11	development	development	NOUN
biomedich-578	164	12	.	.	PUNCT
biomedich-578	165	1	acknowledgments	acknowledgment	NOUN
biomedich-578	165	2	:	:	PUNCT
biomedich-578	165	3	this	this	DET
biomedich-578	165	4	article	article	NOUN
biomedich-578	165	5	process	process	NOUN
biomedich-578	165	6	is	be	AUX
biomedich-578	165	7	sponsored	sponsor	VERB
biomedich-578	165	8	by	by	ADP
biomedich-578	165	9	the	the	DET
biomedich-578	165	10	faculty	faculty	NOUN
biomedich-578	165	11	of	of	ADP
biomedich-578	165	12	medicines	medicine	NOUN
biomedich-578	165	13	and	and	CCONJ
biomedich-578	165	14	health	health	PROPN
biomedich-578	165	15	sciences	sciences	PROPN
biomedich-578	165	16	university	university	PROPN
biomedich-578	165	17	of	of	ADP
biomedich-578	165	18	mataram	mataram	PROPN
biomedich-578	165	19	.	.	PUNCT
biomedich-578	166	1	authors	author	NOUN
biomedich-578	166	2	’	'	PUNCT
biomedich-578	166	3	contributions	contribution	NOUN
biomedich-578	166	4	:	:	PUNCT
biomedich-578	166	5	all	all	DET
biomedich-578	166	6	authors	author	NOUN
biomedich-578	166	7	contributed	contribute	VERB
biomedich-578	166	8	to	to	ADP
biomedich-578	166	9	data	data	NOUN
biomedich-578	166	10	collection	collection	NOUN
biomedich-578	166	11	and	and	CCONJ
biomedich-578	166	12	sourcing	source	VERB
biomedich-578	166	13	related	related	ADJ
biomedich-578	166	14	references	reference	NOUN
biomedich-578	166	15	,	,	PUNCT
biomedich-578	166	16	analyzing	analyze	VERB
biomedich-578	166	17	data	datum	NOUN
biomedich-578	166	18	,	,	PUNCT
biomedich-578	166	19	and	and	CCONJ
biomedich-578	166	20	writing	write	VERB
biomedich-578	166	21	the	the	DET
biomedich-578	166	22	manuscript	manuscript	NOUN
biomedich-578	166	23	.	.	PUNCT
biomedich-578	167	1	herpan	herpan	PROPN
biomedich-578	167	2	and	and	CCONJ
biomedich-578	167	3	arina	arina	PROPN
biomedich-578	167	4	wrote	write	VERB
biomedich-578	167	5	about	about	ADP
biomedich-578	167	6	prime	prime	ADJ
biomedich-578	167	7	targets	target	NOUN
biomedich-578	167	8	in	in	ADP
biomedich-578	167	9	ad	ad	NOUN
biomedich-578	167	10	therapy	therapy	NOUN
biomedich-578	167	11	.	.	PUNCT
biomedich-578	168	1	legis	legis	PROPN
biomedich-578	168	2	wrote	write	VERB
biomedich-578	168	3	about	about	ADP
biomedich-578	168	4	the	the	DET
biomedich-578	168	5	prospects	prospect	NOUN
biomedich-578	168	6	of	of	ADP
biomedich-578	168	7	mnp	mnp	PROPN
biomedich-578	168	8	in	in	ADP
biomedich-578	168	9	ad	ad	NOUN
biomedich-578	168	10	therapy	therapy	NOUN
biomedich-578	168	11	,	,	PUNCT
biomedich-578	168	12	while	while	SCONJ
biomedich-578	168	13	fitriannisa	fitriannisa	NOUN
biomedich-578	168	14	wrote	write	VERB
biomedich-578	168	15	other	other	ADJ
biomedich-578	168	16	components	component	NOUN
biomedich-578	168	17	according	accord	VERB
biomedich-578	168	18	to	to	ADP
biomedich-578	168	19	the	the	DET
biomedich-578	168	20	template	template	NOUN
biomedich-578	168	21	.	.	PUNCT
biomedich-578	169	1	subsequently	subsequently	ADV
biomedich-578	169	2	,	,	PUNCT
biomedich-578	169	3	all	all	DET
biomedich-578	169	4	authors	author	NOUN
biomedich-578	169	5	read	read	VERB
biomedich-578	169	6	and	and	CCONJ
biomedich-578	169	7	approved	approve	VERB
biomedich-578	169	8	the	the	DET
biomedich-578	169	9	final	final	ADJ
biomedich-578	169	10	version	version	NOUN
biomedich-578	169	11	of	of	ADP
biomedich-578	169	12	the	the	DET
biomedich-578	169	13	manuscript	manuscript	NOUN
biomedich-578	169	14	.	.	PUNCT
biomedich-578	170	1	competing	compete	VERB
biomedich-578	170	2	interests	interest	NOUN
biomedich-578	170	3	:	:	PUNCT
biomedich-578	170	4	the	the	DET
biomedich-578	170	5	authors	author	NOUN
biomedich-578	170	6	declare	declare	VERB
biomedich-578	170	7	that	that	SCONJ
biomedich-578	170	8	there	there	PRON
biomedich-578	170	9	are	be	VERB
biomedich-578	170	10	no	no	DET
biomedich-578	170	11	conflicts	conflict	NOUN
biomedich-578	170	12	of	of	ADP
biomedich-578	170	13	interest	interest	NOUN
biomedich-578	170	14	in	in	ADP
biomedich-578	170	15	this	this	DET
biomedich-578	170	16	study	study	NOUN
biomedich-578	170	17	.	.	PUNCT
biomedich-578	171	1	funding	funding	NOUN
biomedich-578	171	2	:	:	PUNCT
biomedich-578	171	3	this	this	DET
biomedich-578	171	4	research	research	NOUN
biomedich-578	171	5	received	receive	VERB
biomedich-578	171	6	no	no	DET
biomedich-578	171	7	specific	specific	ADJ
biomedich-578	171	8	grant	grant	NOUN
biomedich-578	171	9	from	from	ADP
biomedich-578	171	10	any	any	DET
biomedich-578	171	11	funding	funding	NOUN
biomedich-578	171	12	agency	agency	NOUN
biomedich-578	171	13	in	in	ADP
biomedich-578	171	14	the	the	DET
biomedich-578	171	15	public	public	ADJ
biomedich-578	171	16	,	,	PUNCT
biomedich-578	171	17	commercial	commercial	ADJ
biomedich-578	171	18	,	,	PUNCT
biomedich-578	171	19	or	or	CCONJ
biomedich-578	171	20	not	not	PART
biomedich-578	171	21	-	-	PUNCT
biomedich-578	171	22	forprofit	forprofit	NOUN
biomedich-578	171	23	sectors	sector	NOUN
biomedich-578	171	24	.	.	PUNCT
biomedich-578	172	1	references	reference	NOUN
biomedich-578	172	2	altmann	altmann	PROPN
biomedich-578	172	3	kh	kh	PROPN
biomedich-578	172	4	.	.	PUNCT
biomedich-578	172	5	(	(	PUNCT
biomedich-578	172	6	2017	2017	NUM
biomedich-578	172	7	)	)	PUNCT
biomedich-578	172	8	.	.	PUNCT
biomedich-578	173	1	drugs	drug	NOUN
biomedich-578	173	2	from	from	ADP
biomedich-578	173	3	the	the	DET
biomedich-578	173	4	oceans	ocean	NOUN
biomedich-578	173	5	:	:	PUNCT
biomedich-578	173	6	marine	marine	ADJ
biomedich-578	173	7	natural	natural	ADJ
biomedich-578	173	8	products	product	NOUN
biomedich-578	173	9	as	as	SCONJ
biomedich-578	173	10	leads	lead	NOUN
biomedich-578	173	11	for	for	ADP
biomedich-578	173	12	drug	drug	NOUN
biomedich-578	173	13	discovery	discovery	NOUN
biomedich-578	173	14	.	.	PUNCT
biomedich-578	174	1	chimia	chimia	NOUN
biomedich-578	174	2	(	(	PUNCT
biomedich-578	174	3	aarau	aarau	PROPN
biomedich-578	174	4	)	)	PUNCT
biomedich-578	174	5	,	,	PUNCT
biomedich-578	174	6	71(10	71(10	NUM
biomedich-578	174	7	):	):	PUNCT
biomedich-578	174	8	646	646	NUM
biomedich-578	174	9	-	-	SYM
biomedich-578	174	10	652	652	NUM
biomedich-578	174	11	.	.	PUNCT
biomedich-578	175	1	doi.org/10.2533/chimia.2017.646	doi.org/10.2533/chimia.2017.646	NOUN
biomedich-578	175	2	.	.	PUNCT
biomedich-578	176	1	bălașa	bălașa	PROPN
biomedich-578	176	2	af	af	PROPN
biomedich-578	176	3	,	,	PUNCT
biomedich-578	176	4	chircov	chircov	PROPN
biomedich-578	176	5	c	c	NOUN
biomedich-578	176	6	,	,	PUNCT
biomedich-578	176	7	grumezescu	grumezescu	PROPN
biomedich-578	176	8	am	be	AUX
biomedich-578	176	9	.	.	PUNCT
biomedich-578	177	1	(	(	PUNCT
biomedich-578	177	2	2020	2020	NUM
biomedich-578	177	3	)	)	PUNCT
biomedich-578	177	4	.	.	PUNCT
biomedich-578	178	1	marine	marine	PROPN
biomedich-578	178	2	biocompounds	biocompound	VERB
biomedich-578	178	3	for	for	ADP
biomedich-578	178	4	neuroprotection	neuroprotection	NOUN
biomedich-578	178	5	—	—	PUNCT
biomedich-578	178	6	a	a	DET
biomedich-578	178	7	review	review	NOUN
biomedich-578	178	8	.	.	PUNCT
biomedich-578	179	1	marine	marine	ADJ
biomedich-578	179	2	drugs	drug	NOUN
biomedich-578	179	3	,	,	PUNCT
biomedich-578	179	4	18(6	18(6	NOUN
biomedich-578	179	5	):	):	PUNCT
biomedich-578	179	6	1	1	NUM
biomedich-578	179	7	-	-	SYM
biomedich-578	179	8	24	24	NUM
biomedich-578	179	9	.	.	PUNCT
biomedich-578	180	1	doi.org/10.3390/md18060290	doi.org/10.3390/md18060290	PROPN
biomedich-578	180	2	.	.	PUNCT
biomedich-578	181	1	bi	bi	PROPN
biomedich-578	181	2	d	d	PROPN
biomedich-578	181	3	,	,	PUNCT
biomedich-578	181	4	li	li	PROPN
biomedich-578	181	5	x	x	PROPN
biomedich-578	181	6	,	,	PUNCT
biomedich-578	181	7	li	li	PROPN
biomedich-578	181	8	t	t	PROPN
biomedich-578	181	9	,	,	PUNCT
biomedich-578	181	10	li	li	PROPN
biomedich-578	181	11	x	x	PROPN
biomedich-578	181	12	,	,	PUNCT
biomedich-578	181	13	lin	lin	PROPN
biomedich-578	181	14	z	z	PROPN
biomedich-578	181	15	,	,	PUNCT
biomedich-578	181	16	yao	yao	PROPN
biomedich-578	181	17	l	l	PROPN
biomedich-578	181	18	,	,	PUNCT
biomedich-578	181	19	li	li	PROPN
biomedich-578	181	20	h	h	PROPN
biomedich-578	181	21	,	,	PUNCT
biomedich-578	181	22	xu	xu	PROPN
biomedich-578	182	1	h	h	PROPN
biomedich-578	182	2	,	,	PUNCT
biomedich-578	182	3	hu	hu	PROPN
biomedich-578	183	1	z	z	PROPN
biomedich-578	183	2	,	,	PUNCT
biomedich-578	183	3	zhang	zhang	PROPN
biomedich-578	183	4	z	z	PROPN
biomedich-578	183	5	,	,	PUNCT
biomedich-578	183	6	liu	liu	PROPN
biomedich-578	183	7	q	q	PROPN
biomedich-578	183	8	,	,	PUNCT
biomedich-578	183	9	xu	xu	PROPN
biomedich-578	183	10	x.	x.	NOUN
biomedich-578	183	11	(	(	PUNCT
biomedich-578	183	12	2020	2020	NUM
biomedich-578	183	13	)	)	PUNCT
biomedich-578	183	14	.	.	PUNCT
biomedich-578	184	1	characterization	characterization	NOUN
biomedich-578	184	2	and	and	CCONJ
biomedich-578	184	3	neuroprotection	neuroprotection	NOUN
biomedich-578	184	4	potential	potential	NOUN
biomedich-578	184	5	of	of	ADP
biomedich-578	184	6	seleno	seleno	NOUN
biomedich-578	184	7	-	-	PUNCT
biomedich-578	184	8	polymannuronate	polymannuronate	NOUN
biomedich-578	184	9	.	.	PUNCT
biomedich-578	185	1	front	front	PROPN
biomedich-578	185	2	pharmacol	pharmacol	PROPN
biomedich-578	185	3	.	.	PUNCT
biomedich-578	186	1	20	20	NUM
biomedich-578	186	2	:	:	PUNCT
biomedich-578	186	3	11	11	NUM
biomedich-578	186	4	-	-	SYM
biomedich-578	186	5	21	21	NUM
biomedich-578	186	6	.	.	PUNCT
biomedich-578	187	1	doi.org/10.3389/fphar.2020.00021	doi.org/10.3389/fphar.2020.00021	PROPN
biomedich-578	187	2	.	.	PUNCT
biomedich-578	187	3	botelho	botelho	PROPN
biomedich-578	187	4	mj	mj	PROPN
biomedich-578	187	5	,	,	PUNCT
biomedich-578	187	6	milinovic	milinovic	PROPN
biomedich-578	187	7	j	j	PROPN
biomedich-578	187	8	,	,	PUNCT
biomedich-578	187	9	bandarra	bandarra	PROPN
biomedich-578	187	10	nm	nm	PROPN
biomedich-578	187	11	,	,	PUNCT
biomedich-578	187	12	vale	vale	ADJ
biomedich-578	187	13	c.	c.	PROPN
biomedich-578	187	14	(	(	PUNCT
biomedich-578	187	15	2020	2020	NUM
biomedich-578	187	16	)	)	PUNCT
biomedich-578	187	17	.	.	PUNCT
biomedich-578	188	1	alzheimer	alzheimer	PROPN
biomedich-578	188	2	’s	’s	PART
biomedich-578	188	3	disease	disease	NOUN
biomedich-578	188	4	and	and	CCONJ
biomedich-578	188	5	toxins	toxin	NOUN
biomedich-578	188	6	produced	produce	VERB
biomedich-578	188	7	by	by	ADP
biomedich-578	188	8	marine	marine	ADJ
biomedich-578	188	9	dinoflagellates	dinoflagellate	NOUN
biomedich-578	188	10	:	:	PUNCT
biomedich-578	188	11	an	an	DET
biomedich-578	188	12	issue	issue	NOUN
biomedich-578	188	13	to	to	PART
biomedich-578	188	14	explore	explore	VERB
biomedich-578	188	15	.	.	PUNCT
biomedich-578	189	1	marine	marine	ADJ
biomedich-578	189	2	drugs	drug	NOUN
biomedich-578	189	3	,	,	PUNCT
biomedich-578	189	4	20(4):253	20(4):253	NUM
biomedich-578	189	5	.	.	PUNCT
biomedich-578	190	1	doi.org/10.3390/md20040253	doi.org/10.3390/md20040253	PROPN
biomedich-578	190	2	.	.	PUNCT
biomedich-578	191	1	cacabelos	cacabelos	PROPN
biomedich-578	191	2	,	,	PUNCT
biomedich-578	191	3	r.	r.	PROPN
biomedich-578	191	4	(	(	PUNCT
biomedich-578	191	5	2022	2022	NUM
biomedich-578	191	6	)	)	PUNCT
biomedich-578	191	7	.	.	PUNCT
biomedich-578	192	1	what	what	PRON
biomedich-578	192	2	have	have	AUX
biomedich-578	192	3	we	we	PRON
biomedich-578	192	4	learnt	learn	VERB
biomedich-578	192	5	from	from	ADP
biomedich-578	192	6	past	past	ADJ
biomedich-578	192	7	failures	failure	NOUN
biomedich-578	192	8	in	in	ADP
biomedich-578	192	9	alzheimer	alzheimer	PROPN
biomedich-578	192	10	’s	’s	PART
biomedich-578	192	11	disease	disease	NOUN
biomedich-578	192	12	drug	drug	NOUN
biomedich-578	192	13	discovery	discovery	NOUN
biomedich-578	192	14	?	?	PUNCT
biomedich-578	192	15	.	.	PUNCT
biomedich-578	193	1	expert	expert	ADJ
biomedich-578	193	2	opinion	opinion	NOUN
biomedich-578	193	3	on	on	ADP
biomedich-578	193	4	drug	drug	NOUN
biomedich-578	193	5	discovery	discovery	NOUN
biomedich-578	193	6	,	,	PUNCT
biomedich-578	193	7	17(4	17(4	NUM
biomedich-578	193	8	):	):	PUNCT
biomedich-578	193	9	309–323	309–323	NUM
biomedich-578	193	10	.	.	PUNCT
biomedich-578	194	1	doi.org/10.1080/17460441.2022.2033724	doi.org/10.1080/17460441.2022.2033724	PROPN
biomedich-578	194	2	.	.	PUNCT
biomedich-578	194	3	setiawan	setiawan	PROPN
biomedich-578	194	4	et	et	PROPN
biomedich-578	194	5	al	al	PROPN
biomedich-578	194	6	.	.	PROPN
biomedich-578	194	7	–	–	PUNCT
biomedich-578	194	8	physicochemical	physicochemical	ADJ
biomedich-578	194	9	candy	candy	NOUN
biomedich-578	194	10	cinnamon	cinnamon	NOUN
biomedich-578	194	11	seaweed	seaweed	NOUN
biomedich-578	194	12	carrageenan	carrageenan	NOUN
biomedich-578	194	13	.	.	PUNCT
biomedich-578	195	1	441	441	NUM
biomedich-578	195	2	carroll	carroll	PROPN
biomedich-578	195	3	ar	ar	PROPN
biomedich-578	195	4	,	,	PUNCT
biomedich-578	195	5	copp	copp	VERB
biomedich-578	195	6	br	br	PROPN
biomedich-578	195	7	,	,	PUNCT
biomedich-578	195	8	davis	davis	PROPN
biomedich-578	195	9	ra	ra	PROPN
biomedich-578	195	10	,	,	PUNCT
biomedich-578	195	11	keyzers	keyzers	PROPN
biomedich-578	195	12	ra	ra	PROPN
biomedich-578	195	13	,	,	PUNCT
biomedich-578	195	14	prinsep	prinsep	VERB
biomedich-578	195	15	mr	mr	PROPN
biomedich-578	195	16	.	.	PROPN
biomedich-578	195	17	(	(	PUNCT
biomedich-578	195	18	2021	2021	NUM
biomedich-578	195	19	)	)	PUNCT
biomedich-578	195	20	.	.	PUNCT
biomedich-578	196	1	marine	marine	ADJ
biomedich-578	196	2	natural	natural	ADJ
biomedich-578	196	3	products	product	NOUN
biomedich-578	196	4	.	.	PUNCT
biomedich-578	197	1	natural	natural	ADJ
biomedich-578	197	2	product	product	NOUN
biomedich-578	197	3	reports	report	NOUN
biomedich-578	197	4	,	,	PUNCT
biomedich-578	197	5	38(2	38(2	NUM
biomedich-578	197	6	):	):	PUNCT
biomedich-578	197	7	362	362	NUM
biomedich-578	197	8	-	-	SYM
biomedich-578	197	9	413	413	NUM
biomedich-578	197	10	.	.	PUNCT
biomedich-578	198	1	doi.org/10.1039/d0np00089b	doi.org/10.1039/d0np00089b	PROPN
biomedich-578	198	2	.	.	PUNCT
biomedich-578	199	1	cummings	cummings	PROPN
biomedich-578	199	2	jl	jl	PROPN
biomedich-578	199	3	,	,	PUNCT
biomedich-578	199	4	tong	tong	PROPN
biomedich-578	199	5	g	g	PROPN
biomedich-578	199	6	,	,	PUNCT
biomedich-578	199	7	ballard	ballard	PROPN
biomedich-578	199	8	c.	c.	PROPN
biomedich-578	199	9	(	(	PUNCT
biomedich-578	199	10	2019	2019	NUM
biomedich-578	199	11	)	)	PUNCT
biomedich-578	199	12	.	.	PUNCT
biomedich-578	200	1	treatment	treatment	NOUN
biomedich-578	200	2	combinations	combination	NOUN
biomedich-578	200	3	for	for	ADP
biomedich-578	200	4	alzheimer	alzheimer	PROPN
biomedich-578	200	5	's	's	PART
biomedich-578	200	6	disease	disease	NOUN
biomedich-578	200	7	:	:	PUNCT
biomedich-578	200	8	current	current	ADJ
biomedich-578	200	9	and	and	CCONJ
biomedich-578	200	10	future	future	ADJ
biomedich-578	200	11	pharmacotherapy	pharmacotherapy	NOUN
biomedich-578	200	12	options	option	NOUN
biomedich-578	200	13	.	.	PUNCT
biomedich-578	201	1	j	j	PROPN
biomedich-578	201	2	alzheimers	alzheimers	PROPN
biomedich-578	201	3	dis	dis	PROPN
biomedich-578	201	4	,	,	PUNCT
biomedich-578	201	5	67(3	67(3	NUM
biomedich-578	201	6	):	):	PUNCT
biomedich-578	201	7	779	779	NUM
biomedich-578	201	8	-	-	SYM
biomedich-578	201	9	794	794	NUM
biomedich-578	201	10	.	.	PUNCT
biomedich-578	202	1	doi.org/10.3233/jad-180766	doi.org/10.3233/jad-180766	X
biomedich-578	202	2	.	.	PUNCT
biomedich-578	202	3	de	de	PROPN
biomedich-578	202	4	plano	plano	PROPN
biomedich-578	202	5	lm	lm	PROPN
biomedich-578	202	6	,	,	PUNCT
biomedich-578	202	7	calabrese	calabrese	ADJ
biomedich-578	202	8	g	g	PROPN
biomedich-578	202	9	,	,	PUNCT
biomedich-578	202	10	rizzo	rizzo	PROPN
biomedich-578	202	11	mg	mg	PROPN
biomedich-578	202	12	,	,	PUNCT
biomedich-578	202	13	oddo	oddo	VERB
biomedich-578	202	14	s	s	PART
biomedich-578	202	15	,	,	PUNCT
biomedich-578	202	16	caccamo	caccamo	NOUN
biomedich-578	202	17	a.	a.	NOUN
biomedich-578	202	18	(	(	PUNCT
biomedich-578	202	19	2023	2023	NUM
biomedich-578	202	20	)	)	PUNCT
biomedich-578	202	21	.	.	PUNCT
biomedich-578	203	1	the	the	DET
biomedich-578	203	2	role	role	NOUN
biomedich-578	203	3	of	of	ADP
biomedich-578	203	4	the	the	DET
biomedich-578	203	5	transcription	transcription	NOUN
biomedich-578	203	6	factor	factor	NOUN
biomedich-578	203	7	nrf2	nrf2	PROPN
biomedich-578	203	8	in	in	ADP
biomedich-578	203	9	alzheimer	alzheimer	PROPN
biomedich-578	203	10	’s	’s	PART
biomedich-578	203	11	disease	disease	NOUN
biomedich-578	203	12	:	:	PUNCT
biomedich-578	203	13	therapeutic	therapeutic	ADJ
biomedich-578	203	14	opportunities	opportunity	NOUN
biomedich-578	203	15	.	.	PUNCT
biomedich-578	204	1	biomolecules	biomolecule	NOUN
biomedich-578	204	2	,	,	PUNCT
biomedich-578	204	3	13(3):549	13(3):549	NUM
biomedich-578	204	4	.	.	PUNCT
biomedich-578	205	1	doi.org/10.3390/biom13030549	doi.org/10.3390/biom13030549	PROPN
biomedich-578	205	2	.	.	PUNCT
biomedich-578	206	1	dong	dong	PROPN
biomedich-578	206	2	y	y	PROPN
biomedich-578	206	3	,	,	PUNCT
biomedich-578	206	4	li	li	PROPN
biomedich-578	206	5	x	x	PROPN
biomedich-578	206	6	,	,	PUNCT
biomedich-578	206	7	cheng	cheng	PROPN
biomedich-578	206	8	j	j	PROPN
biomedich-578	206	9	,	,	PUNCT
biomedich-578	206	10	hou	hou	PROPN
biomedich-578	206	11	l.	l.	PROPN
biomedich-578	206	12	(	(	PUNCT
biomedich-578	206	13	2019	2019	NUM
biomedich-578	206	14	)	)	PUNCT
biomedich-578	206	15	.	.	PUNCT
biomedich-578	207	1	drug	drug	NOUN
biomedich-578	207	2	development	development	NOUN
biomedich-578	207	3	for	for	ADP
biomedich-578	207	4	alzheimer	alzheimer	PROPN
biomedich-578	207	5	’s	’s	PART
biomedich-578	207	6	disease	disease	NOUN
biomedich-578	207	7	:	:	PUNCT
biomedich-578	207	8	microglia	microglia	ADJ
biomedich-578	207	9	induced	induce	VERB
biomedich-578	207	10	neuroinflammation	neuroinflammation	NOUN
biomedich-578	207	11	as	as	ADP
biomedich-578	207	12	a	a	DET
biomedich-578	207	13	target	target	NOUN
biomedich-578	207	14	?	?	PUNCT
biomedich-578	207	15	.	.	PUNCT
biomedich-578	208	1	int	int	PROPN
biomedich-578	208	2	j	j	PROPN
biomedich-578	208	3	mol	mol	ADP
biomedich-578	208	4	sci	sci	PROPN
biomedich-578	208	5	,	,	PUNCT
biomedich-578	208	6	20(3	20(3	NOUN
biomedich-578	208	7	):	):	PUNCT
biomedich-578	208	8	558	558	NUM
biomedich-578	208	9	.	.	PUNCT
biomedich-578	209	1	doi.org/10.3390/ijms20030558	doi.org/10.3390/ijms20030558	PROPN
biomedich-578	209	2	.	.	PUNCT
biomedich-578	210	1	ferreira	ferreira	PROPN
biomedich-578	210	2	i	i	PROPN
biomedich-578	210	3	,	,	PUNCT
biomedich-578	210	4	rauter	rauter	PROPN
biomedich-578	210	5	ap	ap	PROPN
biomedich-578	210	6	,	,	PUNCT
biomedich-578	210	7	bandarra	bandarra	NOUN
biomedich-578	210	8	nm	nm	PROPN
biomedich-578	210	9	.	.	PUNCT
biomedich-578	210	10	(	(	PUNCT
biomedich-578	210	11	2022	2022	NUM
biomedich-578	210	12	)	)	PUNCT
biomedich-578	210	13	.	.	PUNCT
biomedich-578	211	1	marine	marine	PROPN
biomedich-578	211	2	sources	source	NOUN
biomedich-578	211	3	of	of	ADP
biomedich-578	211	4	dha	dha	PROPN
biomedich-578	211	5	-	-	PUNCT
biomedich-578	211	6	rich	rich	ADJ
biomedich-578	211	7	phospholipids	phospholipid	NOUN
biomedich-578	211	8	with	with	ADP
biomedich-578	211	9	anti	anti	ADJ
biomedich-578	211	10	-	-	ADJ
biomedich-578	211	11	alzheimer	alzheimer	ADJ
biomedich-578	211	12	effect	effect	NOUN
biomedich-578	211	13	.	.	PUNCT
biomedich-578	212	1	marine	marine	ADJ
biomedich-578	212	2	drugs	drug	NOUN
biomedich-578	212	3	.	.	PUNCT
biomedich-578	213	1	2022	2022	NUM
biomedich-578	213	2	,	,	PUNCT
biomedich-578	213	3	20(11	20(11	NUM
biomedich-578	213	4	):	):	PUNCT
biomedich-578	213	5	662	662	NUM
biomedich-578	213	6	.	.	PUNCT
biomedich-578	214	1	doi.org/10.3390/md20110662	doi.org/10.3390/md20110662	NOUN
biomedich-578	214	2	.	.	PUNCT
biomedich-578	214	3	hu	hu	PROPN
biomedich-578	215	1	d	d	PROPN
biomedich-578	215	2	,	,	PUNCT
biomedich-578	215	3	jin	jin	PROPN
biomedich-578	215	4	y	y	PROPN
biomedich-578	215	5	,	,	PUNCT
biomedich-578	215	6	hou	hou	PROPN
biomedich-578	215	7	x	x	PROPN
biomedich-578	215	8	,	,	PUNCT
biomedich-578	215	9	zhu	zhu	PROPN
biomedich-578	215	10	y	y	PROPN
biomedich-578	215	11	,	,	PUNCT
biomedich-578	215	12	chen	chen	PROPN
biomedich-578	215	13	d	d	PROPN
biomedich-578	215	14	,	,	PUNCT
biomedich-578	215	15	tai	tai	PROPN
biomedich-578	215	16	j	j	PROPN
biomedich-578	215	17	,	,	PUNCT
biomedich-578	215	18	chen	chen	PROPN
biomedich-578	215	19	q	q	PROPN
biomedich-578	215	20	,	,	PUNCT
biomedich-578	215	21	shi	shi	PROPN
biomedich-578	215	22	c	c	PROPN
biomedich-578	215	23	,	,	PUNCT
biomedich-578	215	24	ya	ya	PROPN
biomedich-578	215	25	j	j	PROPN
biomedich-578	215	26	,	,	PUNCT
biomedich-578	215	27	wu	wu	PROPN
biomedich-578	215	28	m	m	PROPN
biomedich-578	215	29	,	,	PUNCT
biomedich-578	215	30	et	et	PROPN
biomedich-578	215	31	al	al	PROPN
biomedich-578	215	32	.	.	PROPN
biomedich-578	215	33	(	(	PUNCT
biomedich-578	215	34	2023	2023	NUM
biomedich-578	215	35	)	)	PUNCT
biomedich-578	215	36	.	.	PUNCT
biomedich-578	216	1	application	application	NOUN
biomedich-578	216	2	of	of	ADP
biomedich-578	216	3	marine	marine	ADJ
biomedich-578	216	4	natural	natural	ADJ
biomedich-578	216	5	products	product	NOUN
biomedich-578	216	6	against	against	ADP
biomedich-578	216	7	alzheimer	alzheimer	PROPN
biomedich-578	216	8	’s	’s	PART
biomedich-578	216	9	disease	disease	NOUN
biomedich-578	216	10	:	:	PUNCT
biomedich-578	216	11	past	past	ADJ
biomedich-578	216	12	,	,	PUNCT
biomedich-578	216	13	present	present	ADJ
biomedich-578	216	14	and	and	CCONJ
biomedich-578	216	15	future	future	NOUN
biomedich-578	216	16	.	.	PUNCT
biomedich-578	217	1	marine	marine	ADJ
biomedich-578	217	2	drugs	drug	NOUN
biomedich-578	217	3	,	,	PUNCT
biomedich-578	217	4	21(1	21(1	NUM
biomedich-578	217	5	):	):	PUNCT
biomedich-578	217	6	43	43	NUM
biomedich-578	217	7	.	.	PUNCT
biomedich-578	218	1	doi.org/10.3390/md21010043	doi.org/10.3390/md21010043	NOUN
biomedich-578	218	2	.	.	PUNCT
biomedich-578	219	1	iannuzzi	iannuzzi	PROPN
biomedich-578	219	2	c	c	PROPN
biomedich-578	219	3	,	,	PUNCT
biomedich-578	219	4	borriello	borriello	NOUN
biomedich-578	219	5	m	m	PROPN
biomedich-578	219	6	,	,	PUNCT
biomedich-578	219	7	d'agostino	d'agostino	PROPN
biomedich-578	219	8	a	a	PRON
biomedich-578	219	9	,	,	PUNCT
biomedich-578	219	10	cimini	cimini	PROPN
biomedich-578	219	11	d	d	PROPN
biomedich-578	219	12	,	,	PUNCT
biomedich-578	219	13	schiraldi	schiraldi	PROPN
biomedich-578	219	14	c	c	PROPN
biomedich-578	219	15	,	,	PUNCT
biomedich-578	219	16	sirangelo	sirangelo	NOUN
biomedich-578	219	17	i.	i.	NOUN
biomedich-578	219	18	(	(	PUNCT
biomedich-578	219	19	2019	2019	NUM
biomedich-578	219	20	)	)	PUNCT
biomedich-578	219	21	.	.	PUNCT
biomedich-578	220	1	protective	protective	ADJ
biomedich-578	220	2	effect	effect	NOUN
biomedich-578	220	3	of	of	ADP
biomedich-578	220	4	extractive	extractive	ADJ
biomedich-578	220	5	and	and	CCONJ
biomedich-578	220	6	biotechnological	biotechnological	ADJ
biomedich-578	220	7	chondroitin	chondroitin	NOUN
biomedich-578	220	8	in	in	ADP
biomedich-578	220	9	insulin	insulin	NOUN
biomedich-578	220	10	amyloid	amyloid	NOUN
biomedich-578	220	11	and	and	CCONJ
biomedich-578	220	12	advanced	advanced	ADJ
biomedich-578	220	13	glycation	glycation	NOUN
biomedich-578	220	14	end	end	NOUN
biomedich-578	220	15	product	product	NOUN
biomedich-578	220	16	-	-	PUNCT
biomedich-578	220	17	induced	induce	VERB
biomedich-578	220	18	toxicity	toxicity	NOUN
biomedich-578	220	19	.	.	PUNCT
biomedich-578	221	1	j	j	PROPN
biomedich-578	221	2	cell	cell	NOUN
biomedich-578	221	3	physiol	physiol	PROPN
biomedich-578	221	4	,	,	PUNCT
biomedich-578	221	5	234(4	234(4	NUM
biomedich-578	221	6	):	):	PUNCT
biomedich-578	221	7	3814	3814	NUM
biomedich-578	221	8	-	-	SYM
biomedich-578	221	9	3828	3828	NUM
biomedich-578	221	10	.	.	PUNCT
biomedich-578	221	11	doi.org/10.1002/jcp.27153	doi.org/10.1002/jcp.27153	PROPN
biomedich-578	221	12	.	.	PUNCT
biomedich-578	222	1	jo	jo	PROPN
biomedich-578	222	2	s	s	PROPN
biomedich-578	222	3	-	-	PUNCT
biomedich-578	222	4	l	l	NOUN
biomedich-578	222	5	,	,	PUNCT
biomedich-578	222	6	yang	yang	PROPN
biomedich-578	222	7	h	h	PROPN
biomedich-578	222	8	,	,	PUNCT
biomedich-578	222	9	jeong	jeong	PROPN
biomedich-578	222	10	k	k	PROPN
biomedich-578	222	11	-	-	PROPN
biomedich-578	222	12	j	j	PROPN
biomedich-578	222	13	,	,	PUNCT
biomedich-578	222	14	lee	lee	PROPN
biomedich-578	222	15	h	h	PROPN
biomedich-578	222	16	-	-	PUNCT
biomedich-578	222	17	w	w	PROPN
biomedich-578	222	18	,	,	PUNCT
biomedich-578	222	19	hong	hong	PROPN
biomedich-578	222	20	e	e	PROPN
biomedich-578	222	21	-	-	PROPN
biomedich-578	222	22	j.	j.	X
biomedich-578	222	23	(	(	PUNCT
biomedich-578	222	24	2023	2023	NUM
biomedich-578	222	25	)	)	PUNCT
biomedich-578	222	26	.	.	PUNCT
biomedich-578	223	1	neuroprotective	neuroprotective	ADJ
biomedich-578	223	2	effects	effect	NOUN
biomedich-578	223	3	of	of	ADP
biomedich-578	223	4	ecklonia	ecklonia	NOUN
biomedich-578	223	5	cava	cava	NOUN
biomedich-578	223	6	in	in	ADP
biomedich-578	223	7	a	a	DET
biomedich-578	223	8	chronic	chronic	ADJ
biomedich-578	223	9	neuroinflammatory	neuroinflammatory	NOUN
biomedich-578	223	10	disease	disease	NOUN
biomedich-578	223	11	model	model	NOUN
biomedich-578	223	12	.	.	PUNCT
biomedich-578	224	1	nutrients	nutrient	NOUN
biomedich-578	224	2	.	.	PUNCT
biomedich-578	225	1	15(8	15(8	NUM
biomedich-578	225	2	):	):	PUNCT
biomedich-578	225	3	2007	2007	NUM
biomedich-578	225	4	.	.	PUNCT
biomedich-578	226	1	doi.org/10.3390/nu15082007	doi.org/10.3390/nu15082007	ADJ
biomedich-578	226	2	.	.	PUNCT
biomedich-578	227	1	kabir	kabir	PROPN
biomedich-578	227	2	mt	mt	PROPN
biomedich-578	227	3	,	,	PUNCT
biomedich-578	227	4	uddin	uddin	PROPN
biomedich-578	227	5	ms	ms	PROPN
biomedich-578	227	6	,	,	PUNCT
biomedich-578	227	7	jeandet	jeandet	NOUN
biomedich-578	227	8	p	p	NOUN
biomedich-578	227	9	,	,	PUNCT
biomedich-578	227	10	emran	emran	NOUN
biomedich-578	227	11	tb	tb	NOUN
biomedich-578	227	12	,	,	PUNCT
biomedich-578	227	13	mitra	mitra	PROPN
biomedich-578	227	14	s	s	PROPN
biomedich-578	227	15	,	,	PUNCT
biomedich-578	227	16	albadrani	albadrani	PROPN
biomedich-578	227	17	gm	gm	PROPN
biomedich-578	227	18	,	,	PUNCT
biomedich-578	227	19	sayed	say	VERB
biomedich-578	227	20	aa	aa	PROPN
biomedich-578	227	21	,	,	PUNCT
biomedich-578	227	22	abdel	abdel	PROPN
biomedich-578	227	23	-	-	PUNCT
biomedich-578	227	24	daim	daim	PROPN
biomedich-578	227	25	mm	mm	PROPN
biomedich-578	227	26	,	,	PUNCT
biomedich-578	227	27	simal	simal	PROPN
biomedich-578	227	28	-	-	PUNCT
biomedich-578	227	29	gandara	gandara	PROPN
biomedich-578	227	30	j.	j.	PROPN
biomedich-578	227	31	(	(	PUNCT
biomedich-578	227	32	2021	2021	NUM
biomedich-578	227	33	)	)	PUNCT
biomedich-578	227	34	.	.	PUNCT
biomedich-578	228	1	anti	anti	ADJ
biomedich-578	228	2	-	-	ADJ
biomedich-578	228	3	alzheimer	alzheimer	ADJ
biomedich-578	228	4	’s	’s	PART
biomedich-578	228	5	molecules	molecule	NOUN
biomedich-578	228	6	derived	derive	VERB
biomedich-578	228	7	from	from	ADP
biomedich-578	228	8	marine	marine	ADJ
biomedich-578	228	9	life	life	NOUN
biomedich-578	228	10	:	:	PUNCT
biomedich-578	228	11	understanding	understand	VERB
biomedich-578	228	12	molecular	molecular	ADJ
biomedich-578	228	13	mechanisms	mechanism	NOUN
biomedich-578	228	14	and	and	CCONJ
biomedich-578	228	15	therapeutic	therapeutic	ADJ
biomedich-578	228	16	potential	potential	NOUN
biomedich-578	228	17	.	.	PUNCT
biomedich-578	229	1	marine	marine	ADJ
biomedich-578	229	2	drugs	drug	NOUN
biomedich-578	229	3	,	,	PUNCT
biomedich-578	229	4	19(5):251	19(5):251	NUM
biomedich-578	229	5	.	.	PUNCT
biomedich-578	230	1	doi.org/10.3390/md19050251	doi.org/10.3390/md19050251	PROPN
biomedich-578	230	2	kim	kim	PROPN
biomedich-578	230	3	ck	ck	PROPN
biomedich-578	230	4	,	,	PUNCT
biomedich-578	230	5	lee	lee	PROPN
biomedich-578	230	6	yr	yr	PROPN
biomedich-578	230	7	,	,	PUNCT
biomedich-578	230	8	ong	ong	PROPN
biomedich-578	230	9	l	l	NOUN
biomedich-578	230	10	,	,	PUNCT
biomedich-578	230	11	gold	gold	NOUN
biomedich-578	230	12	m	m	PROPN
biomedich-578	230	13	,	,	PUNCT
biomedich-578	230	14	kalali	kalali	PROPN
biomedich-578	230	15	a	a	X
biomedich-578	230	16	,	,	PUNCT
biomedich-578	230	17	sarkar	sarkar	PROPN
biomedich-578	230	18	j.	j.	PROPN
biomedich-578	230	19	(	(	PUNCT
biomedich-578	230	20	2022	2022	NUM
biomedich-578	230	21	)	)	PUNCT
biomedich-578	230	22	.	.	PUNCT
biomedich-578	231	1	alzheimer	alzheimer	PROPN
biomedich-578	231	2	's	's	PART
biomedich-578	231	3	disease	disease	NOUN
biomedich-578	231	4	:	:	PUNCT
biomedich-578	231	5	key	key	ADJ
biomedich-578	231	6	insights	insight	NOUN
biomedich-578	231	7	from	from	ADP
biomedich-578	231	8	two	two	NUM
biomedich-578	231	9	decades	decade	NOUN
biomedich-578	231	10	of	of	ADP
biomedich-578	231	11	clinical	clinical	ADJ
biomedich-578	231	12	trial	trial	NOUN
biomedich-578	231	13	failures	failure	NOUN
biomedich-578	231	14	.	.	PUNCT
biomedich-578	232	1	j	j	PROPN
biomedich-578	232	2	alzheimers	alzheimers	PROPN
biomedich-578	232	3	dis	dis	PROPN
biomedich-578	232	4	,	,	PUNCT
biomedich-578	232	5	87(1	87(1	NUM
biomedich-578	232	6	):	):	PUNCT
biomedich-578	232	7	83	83	NUM
biomedich-578	232	8	-	-	SYM
biomedich-578	232	9	100	100	NUM
biomedich-578	232	10	.	.	PUNCT
biomedich-578	233	1	doi.org/10.3233/jad-215699	doi.org/10.3233/jad-215699	VERB
biomedich-578	233	2	.	.	PUNCT
biomedich-578	234	1	koelsch	koelsch	PROPN
biomedich-578	234	2	g.	g.	PROPN
biomedich-578	234	3	(	(	PUNCT
biomedich-578	234	4	2017	2017	NUM
biomedich-578	234	5	)	)	PUNCT
biomedich-578	234	6	.	.	PUNCT
biomedich-578	235	1	bace1	bace1	NOUN
biomedich-578	235	2	function	function	NOUN
biomedich-578	235	3	and	and	CCONJ
biomedich-578	235	4	inhibition	inhibition	NOUN
biomedich-578	235	5	:	:	PUNCT
biomedich-578	235	6	implications	implication	NOUN
biomedich-578	235	7	of	of	ADP
biomedich-578	235	8	intervention	intervention	NOUN
biomedich-578	235	9	in	in	ADP
biomedich-578	235	10	the	the	DET
biomedich-578	235	11	amyloid	amyloid	NOUN
biomedich-578	235	12	pathway	pathway	NOUN
biomedich-578	235	13	of	of	ADP
biomedich-578	235	14	alzheimer	alzheimer	PROPN
biomedich-578	235	15	’s	’s	PART
biomedich-578	235	16	disease	disease	NOUN
biomedich-578	235	17	pathology	pathology	NOUN
biomedich-578	235	18	.	.	PUNCT
biomedich-578	236	1	molecules	molecule	NOUN
biomedich-578	236	2	,	,	PUNCT
biomedich-578	236	3	22(10):1723	22(10):1723	NUM
biomedich-578	236	4	.	.	PUNCT
biomedich-578	236	5	doi.org/10.3390/molecules22101723	doi.org/10.3390/molecules22101723	NOUN
biomedich-578	236	6	.	.	PUNCT
biomedich-578	237	1	kong	kong	PROPN
biomedich-578	237	2	y	y	PROPN
biomedich-578	237	3	,	,	PUNCT
biomedich-578	237	4	liu	liu	PROPN
biomedich-578	237	5	c	c	PROPN
biomedich-578	237	6	,	,	PUNCT
biomedich-578	237	7	zhou	zhou	PROPN
biomedich-578	237	8	y	y	PROPN
biomedich-578	237	9	,	,	PUNCT
biomedich-578	237	10	qi	qi	PROPN
biomedich-578	237	11	j	j	PROPN
biomedich-578	237	12	,	,	PUNCT
biomedich-578	237	13	zhang	zhang	PROPN
biomedich-578	237	14	c	c	PROPN
biomedich-578	237	15	,	,	PUNCT
biomedich-578	237	16	sun	sun	PROPN
biomedich-578	237	17	b	b	PROPN
biomedich-578	237	18	,	,	PUNCT
biomedich-578	237	19	wang	wang	PROPN
biomedich-578	237	20	j	j	PROPN
biomedich-578	237	21	,	,	PUNCT
biomedich-578	237	22	guan	guan	PROPN
biomedich-578	237	23	y.	y.	PROPN
biomedich-578	237	24	(	(	PUNCT
biomedich-578	237	25	2020	2020	NUM
biomedich-578	237	26	)	)	PUNCT
biomedich-578	237	27	.	.	PUNCT
biomedich-578	238	1	progress	progress	NOUN
biomedich-578	238	2	of	of	ADP
biomedich-578	238	3	rage	rage	NOUN
biomedich-578	238	4	molecular	molecular	ADJ
biomedich-578	238	5	imaging	imaging	NOUN
biomedich-578	238	6	in	in	ADP
biomedich-578	238	7	alzheimer	alzheimer	PROPN
biomedich-578	238	8	’s	’s	PART
biomedich-578	238	9	disease	disease	NOUN
biomedich-578	238	10	.	.	PUNCT
biomedich-578	239	1	front	front	ADJ
biomedich-578	239	2	.	.	PUNCT
biomedich-578	240	1	aging	age	VERB
biomedich-578	240	2	neurosci	neurosci	PROPN
biomedich-578	240	3	,	,	PUNCT
biomedich-578	240	4	alzheimer	alzheimer	PROPN
biomedich-578	240	5	's	's	PART
biomedich-578	240	6	disease	disease	NOUN
biomedich-578	240	7	and	and	CCONJ
biomedich-578	240	8	related	related	ADJ
biomedich-578	240	9	dementias	dementia	NOUN
biomedich-578	240	10	,	,	PUNCT
biomedich-578	240	11	2020(12	2020(12	NUM
biomedich-578	240	12	):	):	PUNCT
biomedich-578	240	13	1	1	NUM
biomedich-578	240	14	-	-	SYM
biomedich-578	240	15	9	9	NUM
biomedich-578	240	16	.	.	PUNCT
biomedich-578	241	1	doi.org/10.3389/fnagi.2020.00227	doi.org/10.3389/fnagi.2020.00227	PROPN
biomedich-578	241	2	.	.	PUNCT
biomedich-578	242	1	li	li	PROPN
biomedich-578	242	2	dd	dd	PROPN
biomedich-578	242	3	,	,	PUNCT
biomedich-578	242	4	zhang	zhang	PROPN
biomedich-578	242	5	yh	yh	PROPN
biomedich-578	242	6	,	,	PUNCT
biomedich-578	242	7	zhang	zhang	PROPN
biomedich-578	242	8	w	w	PROPN
biomedich-578	242	9	,	,	PUNCT
biomedich-578	242	10	zhao	zhao	PROPN
biomedich-578	242	11	p.	p.	PROPN
biomedich-578	242	12	(	(	PUNCT
biomedich-578	242	13	2019	2019	NUM
biomedich-578	242	14	)	)	PUNCT
biomedich-578	242	15	.	.	PUNCT
biomedich-578	243	1	meta	meta	ADJ
biomedich-578	243	2	-	-	PUNCT
biomedich-578	243	3	analysis	analysis	NOUN
biomedich-578	243	4	of	of	ADP
biomedich-578	243	5	randomized	randomized	ADJ
biomedich-578	243	6	controlled	control	VERB
biomedich-578	243	7	trials	trial	NOUN
biomedich-578	243	8	on	on	ADP
biomedich-578	243	9	the	the	DET
biomedich-578	243	10	efficacy	efficacy	NOUN
biomedich-578	243	11	and	and	CCONJ
biomedich-578	243	12	safety	safety	NOUN
biomedich-578	243	13	of	of	ADP
biomedich-578	243	14	donepezil	donepezil	NOUN
biomedich-578	243	15	,	,	PUNCT
biomedich-578	243	16	galantamine	galantamine	NOUN
biomedich-578	243	17	,	,	PUNCT
biomedich-578	243	18	rivastigmine	rivastigmine	NOUN
biomedich-578	243	19	,	,	PUNCT
biomedich-578	243	20	and	and	CCONJ
biomedich-578	243	21	memantine	memantine	VERB
biomedich-578	243	22	for	for	ADP
biomedich-578	243	23	the	the	DET
biomedich-578	243	24	treatment	treatment	NOUN
biomedich-578	243	25	of	of	ADP
biomedich-578	243	26	alzheimer	alzheimer	PROPN
biomedich-578	243	27	’s	’s	PART
biomedich-578	243	28	disease	disease	NOUN
biomedich-578	243	29	.	.	PUNCT
biomedich-578	244	1	front	front	ADJ
biomedich-578	244	2	neurosci	neurosci	PROPN
biomedich-578	244	3	,	,	PUNCT
biomedich-578	244	4	2019(13	2019(13	NUM
biomedich-578	244	5	):	):	PUNCT
biomedich-578	244	6	118	118	NUM
biomedich-578	244	7	.	.	PUNCT
biomedich-578	245	1	doi.org/10.3389/fnins.2019.00472	doi.org/10.3389/fnins.2019.00472	PROPN
biomedich-578	245	2	.	.	PUNCT
biomedich-578	246	1	lyu	lyu	NOUN
biomedich-578	246	2	,	,	PUNCT
biomedich-578	246	3	c	c	X
biomedich-578	246	4	,	,	PUNCT
biomedich-578	246	5	chen	chen	PROPN
biomedich-578	246	6	t	t	PROPN
biomedich-578	246	7	,	,	PUNCT
biomedich-578	246	8	qiang	qiang	PROPN
biomedich-578	246	9	b	b	PROPN
biomedich-578	246	10	,	,	PUNCT
biomedich-578	246	11	liu	liu	PROPN
biomedich-578	246	12	n	n	PROPN
biomedich-578	246	13	,	,	PUNCT
biomedich-578	246	14	wang	wang	PROPN
biomedich-578	246	15	h	h	PROPN
biomedich-578	246	16	,	,	PUNCT
biomedich-578	246	17	zhang	zhang	PROPN
biomedich-578	246	18	l	l	PROPN
biomedich-578	246	19	,	,	PUNCT
biomedich-578	246	20	liu	liu	PROPN
biomedich-578	246	21	z.	z.	PROPN
biomedich-578	246	22	(	(	PUNCT
biomedich-578	246	23	2021	2021	NUM
biomedich-578	246	24	)	)	PUNCT
biomedich-578	246	25	.	.	PUNCT
biomedich-578	247	1	cmnpd	cmnpd	NOUN
biomedich-578	247	2	:	:	PUNCT
biomedich-578	247	3	a	a	DET
biomedich-578	247	4	comprehensive	comprehensive	ADJ
biomedich-578	247	5	marine	marine	ADJ
biomedich-578	247	6	natural	natural	ADJ
biomedich-578	247	7	products	product	NOUN
biomedich-578	247	8	database	database	NOUN
biomedich-578	247	9	towards	towards	ADP
biomedich-578	247	10	facilitating	facilitate	VERB
biomedich-578	247	11	drug	drug	NOUN
biomedich-578	247	12	discovery	discovery	NOUN
biomedich-578	247	13	from	from	ADP
biomedich-578	247	14	the	the	DET
biomedich-578	247	15	ocean	ocean	NOUN
biomedich-578	247	16	.	.	PUNCT
biomedich-578	248	1	nucleic	nucleic	ADJ
biomedich-578	248	2	acids	acid	NOUN
biomedich-578	248	3	res	re	NOUN
biomedich-578	248	4	,	,	PUNCT
biomedich-578	248	5	49(1	49(1	NOUN
biomedich-578	248	6	)	)	PUNCT
biomedich-578	248	7	,	,	PUNCT
biomedich-578	248	8	509	509	NUM
biomedich-578	248	9	-	-	SYM
biomedich-578	248	10	515	515	NUM
biomedich-578	248	11	.	.	PUNCT
biomedich-578	249	1	doi	doi	NOUN
biomedich-578	249	2	:	:	PUNCT
biomedich-578	249	3	10.1093	10.1093	NUM
biomedich-578	249	4	/	/	SYM
biomedich-578	249	5	nar	nar	NOUN
biomedich-578	249	6	/	/	SYM
biomedich-578	249	7	gkaa763	gkaa763	PROPN
biomedich-578	249	8	.	.	PUNCT
biomedich-578	250	1	martins	martin	NOUN
biomedich-578	250	2	m	m	PROPN
biomedich-578	250	3	,	,	PUNCT
biomedich-578	250	4	silva	silva	PROPN
biomedich-578	250	5	r	r	PROPN
biomedich-578	250	6	,	,	PUNCT
biomedich-578	250	7	m.	m.	NOUN
biomedich-578	250	8	m.	m.	NOUN
biomedich-578	250	9	pinto	pinto	PROPN
biomedich-578	250	10	m	m	PROPN
biomedich-578	250	11	,	,	PUNCT
biomedich-578	250	12	sousa	sousa	PROPN
biomedich-578	250	13	e.	e.	PROPN
biomedich-578	250	14	(	(	PUNCT
biomedich-578	250	15	2020	2020	NUM
biomedich-578	250	16	)	)	PUNCT
biomedich-578	250	17	.	.	PUNCT
biomedich-578	251	1	marine	marine	PROPN
biomedich-578	251	2	natural	natural	ADJ
biomedich-578	251	3	products	product	NOUN
biomedich-578	251	4	,	,	PUNCT
biomedich-578	251	5	multitarget	multitarget	NOUN
biomedich-578	251	6	therapy	therapy	NOUN
biomedich-578	251	7	and	and	CCONJ
biomedich-578	251	8	repurposed	repurpose	VERB
biomedich-578	251	9	agents	agent	NOUN
biomedich-578	251	10	in	in	ADP
biomedich-578	251	11	alzheimer	alzheimer	PROPN
biomedich-578	251	12	’s	’s	PART
biomedich-578	251	13	disease	disease	NOUN
biomedich-578	251	14	.	.	PUNCT
biomedich-578	252	1	pharmaceuticals	pharmaceutical	NOUN
biomedich-578	252	2	,	,	PUNCT
biomedich-578	252	3	13(9	13(9	NUM
biomedich-578	252	4	):	):	PUNCT
biomedich-578	252	5	242	242	NUM
biomedich-578	252	6	.	.	PUNCT
biomedich-578	253	1	doi.org/10.3390/ph13090242	doi.org/10.3390/ph13090242	PROPN
biomedich-578	253	2	.	.	PUNCT
biomedich-578	254	1	mehta	mehta	PROPN
biomedich-578	254	2	d	d	PROPN
biomedich-578	254	3	,	,	PUNCT
biomedich-578	254	4	jackson	jackson	PROPN
biomedich-578	254	5	r	r	PROPN
biomedich-578	254	6	,	,	PUNCT
biomedich-578	254	7	paul	paul	PROPN
biomedich-578	254	8	g	g	PROPN
biomedich-578	254	9	,	,	PUNCT
biomedich-578	254	10	shi	shi	PROPN
biomedich-578	254	11	j	j	PROPN
biomedich-578	254	12	,	,	PUNCT
biomedich-578	254	13	sabbagh	sabbagh	PROPN
biomedich-578	254	14	,	,	PUNCT
biomedich-578	254	15	m.	m.	NOUN
biomedich-578	254	16	(	(	PUNCT
biomedich-578	254	17	2017	2017	NUM
biomedich-578	254	18	)	)	PUNCT
biomedich-578	254	19	.	.	PUNCT
biomedich-578	255	1	why	why	SCONJ
biomedich-578	255	2	do	do	AUX
biomedich-578	255	3	trials	trial	NOUN
biomedich-578	255	4	for	for	ADP
biomedich-578	255	5	alzheimer	alzheimer	PROPN
biomedich-578	255	6	’s	’s	PART
biomedich-578	255	7	disease	disease	NOUN
biomedich-578	255	8	drugs	drug	NOUN
biomedich-578	255	9	keep	keep	VERB
biomedich-578	255	10	failing	fail	VERB
biomedich-578	255	11	?	?	PUNCT
biomedich-578	256	1	a	a	DET
biomedich-578	256	2	discontinued	discontinue	VERB
biomedich-578	256	3	drug	drug	NOUN
biomedich-578	256	4	perspective	perspective	NOUN
biomedich-578	256	5	for	for	ADP
biomedich-578	256	6	2010	2010	NUM
biomedich-578	256	7	-	-	SYM
biomedich-578	256	8	2015	2015	NUM
biomedich-578	256	9	.	.	PUNCT
biomedich-578	257	1	expert	expert	ADJ
biomedich-578	257	2	opinion	opinion	NOUN
biomedich-578	257	3	on	on	ADP
biomedich-578	257	4	investigational	investigational	ADJ
biomedich-578	257	5	drugs	drug	NOUN
biomedich-578	257	6	,	,	PUNCT
biomedich-578	257	7	26(6	26(6	NUM
biomedich-578	257	8	):	):	PUNCT
biomedich-578	257	9	735–739	735–739	NUM
biomedich-578	257	10	.	.	PUNCT
biomedich-578	257	11	doi.org/10.1080/13543784.2017.1323868	doi.org/10.1080/13543784.2017.1323868	PROPN
biomedich-578	257	12	.	.	PUNCT
biomedich-578	258	1	montaser	montaser	PROPN
biomedich-578	258	2	r	r	NOUN
biomedich-578	258	3	,	,	PUNCT
biomedich-578	258	4	luesch	luesch	NOUN
biomedich-578	258	5	h.	h.	PROPN
biomedich-578	258	6	(	(	PUNCT
biomedich-578	258	7	2011	2011	NUM
biomedich-578	258	8	)	)	PUNCT
biomedich-578	258	9	.	.	PUNCT
biomedich-578	259	1	marine	marine	PROPN
biomedich-578	259	2	natural	natural	ADJ
biomedich-578	259	3	products	product	NOUN
biomedich-578	259	4	:	:	PUNCT
biomedich-578	259	5	a	a	DET
biomedich-578	259	6	new	new	ADJ
biomedich-578	259	7	wave	wave	NOUN
biomedich-578	259	8	of	of	ADP
biomedich-578	259	9	drugs	drug	NOUN
biomedich-578	259	10	?	?	PUNCT
biomedich-578	260	1	future	future	ADJ
biomedich-578	260	2	med	med	ADJ
biomedich-578	260	3	chem	chem	NOUN
biomedich-578	260	4	,	,	PUNCT
biomedich-578	260	5	3(12):1475	3(12):1475	NUM
biomedich-578	260	6	-	-	SYM
biomedich-578	260	7	89	89	NUM
biomedich-578	260	8	.	.	PUNCT
biomedich-578	261	1	doi.org/10.4155/fmc.11.118	doi.org/10.4155/fmc.11.118	VERB
biomedich-578	261	2	.	.	PUNCT
biomedich-578	262	1	mycroft	mycroft	PROPN
biomedich-578	262	2	-	-	PUNCT
biomedich-578	262	3	west	west	PROPN
biomedich-578	262	4	cj	cj	PROPN
biomedich-578	262	5	,	,	PUNCT
biomedich-578	262	6	devlin	devlin	PROPN
biomedich-578	262	7	aj	aj	PROPN
biomedich-578	262	8	,	,	PUNCT
biomedich-578	262	9	cooper	cooper	PROPN
biomedich-578	262	10	lc	lc	PROPN
biomedich-578	262	11	,	,	PUNCT
biomedich-578	262	12	guimond	guimond	NOUN
biomedich-578	262	13	se	se	PROPN
biomedich-578	262	14	,	,	PUNCT
biomedich-578	262	15	procter	procter	PROPN
biomedich-578	262	16	p	p	PROPN
biomedich-578	262	17	,	,	PUNCT
biomedich-578	262	18	guerrini	guerrini	PROPN
biomedich-578	262	19	m	m	PROPN
biomedich-578	262	20	,	,	PUNCT
biomedich-578	262	21	miller	miller	PROPN
biomedich-578	262	22	gj	gj	PROPN
biomedich-578	262	23	,	,	PUNCT
biomedich-578	262	24	fernig	fernig	PROPN
biomedich-578	262	25	dg	dg	PROPN
biomedich-578	262	26	,	,	PUNCT
biomedich-578	262	27	yates	yates	PROPN
biomedich-578	262	28	ea	ea	PROPN
biomedich-578	262	29	,	,	PUNCT
biomedich-578	262	30	lima	lima	PROPN
biomedich-578	262	31	ma	ma	PROPN
biomedich-578	262	32	,	,	PUNCT
biomedich-578	262	33	et	et	PROPN
biomedich-578	262	34	al	al	PROPN
biomedich-578	262	35	.	.	PROPN
biomedich-578	262	36	(	(	PUNCT
biomedich-578	262	37	2021	2021	NUM
biomedich-578	262	38	)	)	PUNCT
biomedich-578	262	39	.	.	PUNCT
biomedich-578	263	1	glycosaminoglycans	glycosaminoglycan	NOUN
biomedich-578	263	2	from	from	ADP
biomedich-578	263	3	litopenaeus	litopenaeus	PROPN
biomedich-578	263	4	vannamei	vannamei	PROPN
biomedich-578	263	5	inhibit	inhibit	VERB
biomedich-578	263	6	the	the	DET
biomedich-578	263	7	alzheimer	alzheimer	PROPN
biomedich-578	263	8	’s	’s	PART
biomedich-578	263	9	disease	disease	NOUN
biomedich-578	263	10	β	β	PROPN
biomedich-578	263	11	secretase	secretase	PROPN
biomedich-578	263	12	,	,	PUNCT
biomedich-578	263	13	bace1	bace1	PROPN
biomedich-578	263	14	.	.	PUNCT
biomedich-578	264	1	marine	marine	PROPN
biomedich-578	264	2	drugs	drug	NOUN
biomedich-578	264	3	,	,	PUNCT
biomedich-578	264	4	19(4	19(4	NUM
biomedich-578	264	5	):	):	PUNCT
biomedich-578	264	6	203	203	NUM
biomedich-578	264	7	.	.	PUNCT
biomedich-578	265	1	doi.org/10.3390/md19040203	doi.org/10.3390/md19040203	PROPN
biomedich-578	265	2	nugraha	nugraha	PROPN
biomedich-578	265	3	as	as	ADP
biomedich-578	265	4	,	,	PUNCT
biomedich-578	265	5	firli	firli	PROPN
biomedich-578	265	6	ln	ln	PROPN
biomedich-578	265	7	,	,	PUNCT
biomedich-578	265	8	rani	rani	PROPN
biomedich-578	265	9	dm	dm	PROPN
biomedich-578	265	10	,	,	PUNCT
biomedich-578	265	11	et	et	PROPN
biomedich-578	265	12	al	al	PROPN
biomedich-578	265	13	.	.	PROPN
biomedich-578	266	1	(	(	PUNCT
biomedich-578	266	2	2023	2023	NUM
biomedich-578	266	3	)	)	PUNCT
biomedich-578	266	4	.	.	PUNCT
biomedich-578	267	1	indonesian	indonesian	ADJ
biomedich-578	267	2	marine	marine	PROPN
biomedich-578	267	3	and	and	CCONJ
biomedich-578	267	4	its	its	PRON
biomedich-578	267	5	medicinal	medicinal	ADJ
biomedich-578	267	6	contribution	contribution	NOUN
biomedich-578	267	7	.	.	PUNCT
biomedich-578	268	1	nat	nat	PROPN
biomedich-578	268	2	.	.	PUNCT
biomedich-578	269	1	prod	prod	PROPN
biomedich-578	269	2	.	.	PUNCT
biomedich-578	270	1	bioprospect	bioprospect	PROPN
biomedich-578	270	2	,	,	PUNCT
biomedich-578	270	3	13(38	13(38	NUM
biomedich-578	270	4	):	):	PUNCT
biomedich-578	270	5	1	1	NUM
biomedich-578	270	6	-	-	SYM
biomedich-578	270	7	27	27	NUM
biomedich-578	270	8	.	.	PUNCT
biomedich-578	271	1	doi.org/10.1007/s13659-023-00403-1	doi.org/10.1007/s13659-023-00403-1	PROPN
biomedich-578	271	2	.	.	PUNCT
biomedich-578	272	1	osama	osama	PROPN
biomedich-578	272	2	a	a	PRON
biomedich-578	272	3	,	,	PUNCT
biomedich-578	272	4	zhang	zhang	PROPN
biomedich-578	272	5	j	j	PROPN
biomedich-578	272	6	,	,	PUNCT
biomedich-578	272	7	yao	yao	PROPN
biomedich-578	272	8	j	j	PROPN
biomedich-578	272	9	,	,	PUNCT
biomedich-578	272	10	yao	yao	PROPN
biomedich-578	272	11	x	x	PRON
biomedich-578	272	12	,	,	PUNCT
biomedich-578	272	13	fang	fang	PROPN
biomedich-578	272	14	j.	j.	PROPN
biomedich-578	272	15	(	(	PUNCT
biomedich-578	272	16	2020	2020	NUM
biomedich-578	272	17	)	)	PUNCT
biomedich-578	272	18	.	.	PUNCT
biomedich-578	273	1	nrf2	nrf2	PROPN
biomedich-578	273	2	:	:	PUNCT
biomedich-578	273	3	a	a	DET
biomedich-578	273	4	dark	dark	ADJ
biomedich-578	273	5	horse	horse	NOUN
biomedich-578	273	6	in	in	ADP
biomedich-578	273	7	alzheimer	alzheimer	PROPN
biomedich-578	273	8	's	's	PART
biomedich-578	273	9	disease	disease	NOUN
biomedich-578	273	10	treatment	treatment	NOUN
biomedich-578	273	11	.	.	PUNCT
biomedich-578	274	1	ageing	age	VERB
biomedich-578	274	2	research	research	NOUN
biomedich-578	274	3	reviews	review	NOUN
biomedich-578	274	4	,	,	PUNCT
biomedich-578	274	5	64	64	NUM
biomedich-578	274	6	:	:	SYM
biomedich-578	274	7	1	1	NUM
biomedich-578	274	8	-	-	SYM
biomedich-578	274	9	45	45	NUM
biomedich-578	274	10	.	.	PUNCT
biomedich-578	275	1	doi.org/10.1016/j.arr.2020.101206	doi.org/10.1016/j.arr.2020.101206	PROPN
biomedich-578	275	2	.	.	PUNCT
biomedich-578	276	1	park	park	NOUN
biomedich-578	276	2	sk	sk	PROPN
biomedich-578	276	3	,	,	PUNCT
biomedich-578	276	4	kang	kang	PROPN
biomedich-578	276	5	jy	jy	PROPN
biomedich-578	276	6	,	,	PUNCT
biomedich-578	276	7	kim	kim	PROPN
biomedich-578	276	8	jm	jm	PROPN
biomedich-578	276	9	,	,	PUNCT
biomedich-578	276	10	yoo	yoo	PROPN
biomedich-578	276	11	sk	sk	PROPN
biomedich-578	276	12	,	,	PUNCT
biomedich-578	276	13	han	han	PROPN
biomedich-578	276	14	hj	hj	PROPN
biomedich-578	276	15	,	,	PUNCT
biomedich-578	276	16	chung	chung	PROPN
biomedich-578	276	17	dh	dh	PROPN
biomedich-578	276	18	,	,	PUNCT
biomedich-578	276	19	kim	kim	PROPN
biomedich-578	276	20	do	do	VERB
biomedich-578	276	21	,	,	PUNCT
biomedich-578	276	22	kim	kim	PROPN
biomedich-578	276	23	g	g	PROPN
biomedich-578	276	24	-	-	PUNCT
biomedich-578	276	25	h	h	PROPN
biomedich-578	276	26	,	,	PUNCT
biomedich-578	276	27	heo	heo	PROPN
biomedich-578	276	28	hj	hj	PROPN
biomedich-578	276	29	.	.	PROPN
biomedich-578	276	30	(	(	PUNCT
biomedich-578	276	31	2019	2019	NUM
biomedich-578	276	32	)	)	PUNCT
biomedich-578	276	33	.	.	PUNCT
biomedich-578	277	1	fucoidan	fucoidan	ADJ
biomedich-578	277	2	-	-	PUNCT
biomedich-578	277	3	rich	rich	ADJ
biomedich-578	277	4	substances	substance	NOUN
biomedich-578	277	5	from	from	ADP
biomedich-578	277	6	ecklonia	ecklonia	NOUN
biomedich-578	277	7	cava	cava	NOUN
biomedich-578	277	8	improve	improve	VERB
biomedich-578	277	9	trimethyltin	trimethyltin	NOUN
biomedich-578	277	10	-	-	PUNCT
biomedich-578	277	11	induced	induce	VERB
biomedich-578	277	12	cognitive	cognitive	ADJ
biomedich-578	277	13	dysfunction	dysfunction	NOUN
biomedich-578	277	14	via	via	ADP
biomedich-578	277	15	down	down	ADP
biomedich-578	277	16	-	-	PUNCT
biomedich-578	277	17	regulation	regulation	NOUN
biomedich-578	277	18	of	of	ADP
biomedich-578	277	19	amyloid	amyloid	NOUN
biomedich-578	277	20	β	β	PROPN
biomedich-578	277	21	production	production	NOUN
biomedich-578	277	22	/	/	SYM
biomedich-578	277	23	tau	tau	PROPN
biomedich-578	277	24	hyperphosphorylation	hyperphosphorylation	NOUN
biomedich-578	277	25	.	.	PUNCT
biomedich-578	278	1	marine	marine	ADJ
biomedich-578	278	2	drugs	drug	NOUN
biomedich-578	278	3	,	,	PUNCT
biomedich-578	278	4	17(10	17(10	NUM
biomedich-578	278	5	):	):	PUNCT
biomedich-578	278	6	591	591	NUM
biomedich-578	278	7	.	.	PUNCT
biomedich-578	279	1	doi.org/10.3390/md17100591	doi.org/10.3390/md17100591	VERB
biomedich-578	279	2	reddy	reddy	PROPN
biomedich-578	279	3	vp	vp	PROPN
biomedich-578	279	4	,	,	PUNCT
biomedich-578	279	5	aryal	aryal	PROPN
biomedich-578	279	6	p	p	PROPN
biomedich-578	279	7	,	,	PUNCT
biomedich-578	279	8	soni	soni	PROPN
biomedich-578	279	9	p.	p.	PROPN
biomedich-578	279	10	(	(	PUNCT
biomedich-578	279	11	2023	2023	NUM
biomedich-578	279	12	)	)	PUNCT
biomedich-578	279	13	.	.	PUNCT
biomedich-578	280	1	rage	rage	NOUN
biomedich-578	280	2	inhibitors	inhibitor	NOUN
biomedich-578	280	3	in	in	ADP
biomedich-578	280	4	neurodegenerative	neurodegenerative	ADJ
biomedich-578	280	5	diseases	disease	NOUN
biomedich-578	280	6	.	.	PUNCT
biomedich-578	281	1	biomedicines	biomedicine	NOUN
biomedich-578	281	2	,	,	PUNCT
biomedich-578	281	3	11(4):1131	11(4):1131	PROPN
biomedich-578	281	4	.	.	PUNCT
biomedich-578	281	5	doi.org/10.3390/biomedicines11041131	doi.org/10.3390/biomedicines11041131	PROPN
biomedich-578	281	6	.	.	PUNCT
biomedich-578	282	1	rivarti	rivarti	PROPN
biomedich-578	282	2	aw	aw	INTJ
biomedich-578	282	3	,	,	PUNCT
biomedich-578	282	4	saputri	saputri	ADJ
biomedich-578	282	5	lo	lo	PROPN
biomedich-578	282	6	,	,	PUNCT
biomedich-578	282	7	harahap	harahap	PROPN
biomedich-578	282	8	hs	hs	PROPN
biomedich-578	282	9	,	,	PUNCT
biomedich-578	282	10	permatasari	permatasari	PROPN
biomedich-578	282	11	,	,	PUNCT
biomedich-578	282	12	l.	l.	PROPN
biomedich-578	282	13	(	(	PUNCT
biomedich-578	282	14	2023	2023	NUM
biomedich-578	282	15	)	)	PUNCT
biomedich-578	282	16	.	.	PUNCT
biomedich-578	283	1	alzheimer	alzheimer	PROPN
biomedich-578	283	2	’s	’s	PART
biomedich-578	283	3	disease	disease	NOUN
biomedich-578	283	4	from	from	ADP
biomedich-578	283	5	a	a	DET
biomedich-578	283	6	diabetic	diabetic	ADJ
biomedich-578	283	7	brain	brain	NOUN
biomedich-578	283	8	:	:	PUNCT
biomedich-578	283	9	exploring	explore	VERB
biomedich-578	283	10	the	the	DET
biomedich-578	283	11	molecular	molecular	ADJ
biomedich-578	283	12	process	process	NOUN
biomedich-578	283	13	to	to	PART
biomedich-578	283	14	determine	determine	VERB
biomedich-578	283	15	the	the	DET
biomedich-578	283	16	potential	potential	ADJ
biomedich-578	283	17	therapy	therapy	NOUN
biomedich-578	283	18	target	target	NOUN
biomedich-578	283	19	from	from	ADP
biomedich-578	283	20	marine	marine	PROPN
biomedich-578	283	21	sources	source	NOUN
biomedich-578	283	22	.	.	PUNCT
biomedich-578	284	1	pharmacy	pharmacy	NOUN
biomedich-578	284	2	education	education	NOUN
biomedich-578	284	3	,	,	PUNCT
biomedich-578	284	4	23(4	23(4	NUM
biomedich-578	284	5	):	):	PUNCT
biomedich-578	284	6	189	189	NUM
biomedich-578	284	7	-	-	SYM
biomedich-578	284	8	195	195	NUM
biomedich-578	284	9	.	.	PUNCT
biomedich-578	285	1	doi.org/10.46542/pe.2023.234.189195	doi.org/10.46542/pe.2023.234.189195	PROPN
biomedich-578	285	2	.	.	PROPN
biomedich-578	285	3	sayas	sayas	PROPN
biomedich-578	285	4	cl	cl	PROPN
biomedich-578	285	5	,	,	PUNCT
biomedich-578	285	6	ávila	ávila	PROPN
biomedich-578	285	7	j.	j.	PROPN
biomedich-578	285	8	(	(	PUNCT
biomedich-578	285	9	2021	2021	NUM
biomedich-578	285	10	)	)	PUNCT
biomedich-578	285	11	.	.	PUNCT
biomedich-578	286	1	gsk-3	gsk-3	PUNCT
biomedich-578	286	2	and	and	CCONJ
biomedich-578	286	3	tau	tau	PROPN
biomedich-578	286	4	:	:	PUNCT
biomedich-578	286	5	a	a	DET
biomedich-578	286	6	key	key	ADJ
biomedich-578	286	7	duet	duet	NOUN
biomedich-578	286	8	in	in	ADP
biomedich-578	286	9	alzheimer	alzheimer	PROPN
biomedich-578	286	10	’s	’s	PART
biomedich-578	286	11	disease	disease	NOUN
biomedich-578	286	12	.	.	PUNCT
biomedich-578	287	1	cells	cell	NOUN
biomedich-578	287	2	.	.	PUNCT
biomedich-578	288	1	10(4	10(4	NUM
biomedich-578	288	2	):	):	PUNCT
biomedich-578	288	3	721	721	NUM
biomedich-578	288	4	.	.	PUNCT
biomedich-578	289	1	doi.org/10.3390/cells10040721	doi.org/10.3390/cells10040721	PROPN
biomedich-578	289	2	shatshat	shatshat	PROPN
biomedich-578	289	3	al	al	PROPN
biomedich-578	289	4	,	,	PUNCT
biomedich-578	289	5	pham	pham	PROPN
biomedich-578	289	6	at	at	ADP
biomedich-578	289	7	,	,	PUNCT
biomedich-578	289	8	rao	rao	PROPN
biomedich-578	289	9	ppn	ppn	PROPN
biomedich-578	289	10	.	.	PUNCT
biomedich-578	289	11	(	(	PUNCT
biomedich-578	289	12	2019	2019	NUM
biomedich-578	289	13	)	)	PUNCT
biomedich-578	289	14	.	.	PUNCT
biomedich-578	290	1	interactions	interaction	NOUN
biomedich-578	290	2	of	of	ADP
biomedich-578	290	3	polyunsaturated	polyunsaturated	ADJ
biomedich-578	290	4	fatty	fatty	NOUN
biomedich-578	290	5	acids	acid	NOUN
biomedich-578	290	6	with	with	ADP
biomedich-578	290	7	amyloid	amyloid	NOUN
biomedich-578	290	8	peptides	peptide	NOUN
biomedich-578	290	9	aβ40	aβ40	PROPN
biomedich-578	290	10	and	and	CCONJ
biomedich-578	290	11	aβ42	aβ42	PROPN
biomedich-578	290	12	.	.	PUNCT
biomedich-578	291	1	archives	archive	NOUN
biomedich-578	291	2	of	of	ADP
biomedich-578	291	3	biochemistry	biochemistry	NOUN
biomedich-578	291	4	and	and	CCONJ
biomedich-578	291	5	biophysics	biophysic	NOUN
biomedich-578	291	6	,	,	PUNCT
biomedich-578	291	7	663(15	663(15	NUM
biomedich-578	291	8	):	):	PUNCT
biomedich-578	291	9	3443	3443	NUM
biomedich-578	291	10	.	.	PUNCT
biomedich-578	292	1	doi.org/10.1016/j.abb.2018.12.027	doi.org/10.1016/j.abb.2018.12.027	PROPN
biomedich-578	292	2	.	.	PUNCT
biomedich-578	293	1	silva	silva	PROPN
biomedich-578	293	2	m	m	PROPN
biomedich-578	293	3	,	,	PUNCT
biomedich-578	293	4	seijas	seijas	PROPN
biomedich-578	293	5	p	p	PROPN
biomedich-578	293	6	,	,	PUNCT
biomedich-578	293	7	otero	otero	PROPN
biomedich-578	293	8	p.	p.	NOUN
biomedich-578	293	9	(	(	PUNCT
biomedich-578	293	10	2021	2021	NUM
biomedich-578	293	11	)	)	PUNCT
biomedich-578	293	12	.	.	PUNCT
biomedich-578	294	1	exploitation	exploitation	NOUN
biomedich-578	294	2	of	of	ADP
biomedich-578	294	3	marine	marine	ADJ
biomedich-578	294	4	molecules	molecule	NOUN
biomedich-578	294	5	to	to	PART
biomedich-578	294	6	manage	manage	VERB
biomedich-578	294	7	alzheimer	alzheimer	PROPN
biomedich-578	294	8	's	's	PART
biomedich-578	294	9	disease	disease	NOUN
biomedich-578	294	10	.	.	PUNCT
biomedich-578	295	1	mar	mar	PROPN
biomedich-578	295	2	drugs	drugs	PROPN
biomedich-578	295	3	,	,	PUNCT
biomedich-578	295	4	19(7	19(7	PROPN
biomedich-578	295	5	):	):	PUNCT
biomedich-578	295	6	373	373	NUM
biomedich-578	295	7	.	.	PUNCT
biomedich-578	296	1	doi.org/10.3390/md19070373	doi.org/10.3390/md19070373	NOUN
biomedich-578	296	2	.	.	PUNCT
biomedich-578	296	3	stevenson	stevenson	PROPN
biomedich-578	296	4	,	,	PUNCT
biomedich-578	296	5	me	i	PRON
biomedich-578	296	6	,	,	PUNCT
biomedich-578	296	7	hebron	hebron	PROPN
biomedich-578	296	8	m	m	PROPN
biomedich-578	296	9	,	,	PUNCT
biomedich-578	296	10	liu	liu	PROPN
biomedich-578	296	11	x	x	PROPN
biomedich-578	296	12	,	,	PUNCT
biomedich-578	296	13	kavulu	kavulu	VERB
biomedich-578	296	14	b	b	NOUN
biomedich-578	296	15	,	,	PUNCT
biomedich-578	296	16	wolf	wolf	PROPN
biomedich-578	296	17	c	c	PROPN
biomedich-578	296	18	,	,	PUNCT
biomedich-578	296	19	moussa	moussa	PROPN
biomedich-578	296	20	,	,	PUNCT
biomedich-578	296	21	ceh	ceh	PROPN
biomedich-578	296	22	.	.	PROPN
biomedich-578	296	23	(	(	PUNCT
biomedich-578	296	24	2022	2022	NUM
biomedich-578	296	25	)	)	PUNCT
biomedich-578	296	26	.	.	PUNCT
biomedich-578	297	1	inhibiting	inhibit	VERB
biomedich-578	297	2	tyrosine	tyrosine	NOUN
biomedich-578	297	3	kinase	kinase	NOUN
biomedich-578	297	4	c	c	NOUN
biomedich-578	297	5	-	-	PUNCT
biomedich-578	297	6	kit	kit	NOUN
biomedich-578	297	7	as	as	ADP
biomedich-578	297	8	a	a	DET
biomedich-578	297	9	therapeutic	therapeutic	ADJ
biomedich-578	297	10	strategy	strategy	NOUN
biomedich-578	297	11	for	for	ADP
biomedich-578	297	12	alzheimer	alzheimer	PROPN
biomedich-578	297	13	’s	’s	PART
biomedich-578	297	14	disease	disease	NOUN
biomedich-578	297	15	.	.	PUNCT
biomedich-578	298	1	alzheimer	alzheimer	PROPN
biomedich-578	298	2	's	's	PART
biomedich-578	298	3	dement	dement	NOUN
biomedich-578	298	4	.	.	PUNCT
biomedich-578	298	5	,	,	PUNCT
biomedich-578	298	6	18(10	18(10	NUM
biomedich-578	298	7	):	):	PUNCT
biomedich-578	298	8	1	1	NUM
biomedich-578	298	9	.	.	X
biomedich-578	298	10	doi.org/10.1002/alz.068944	doi.org/10.1002/alz.068944	PROPN
biomedich-578	298	11	wang	wang	PROPN
biomedich-578	298	12	r	r	PROPN
biomedich-578	298	13	,	,	PUNCT
biomedich-578	298	14	reddy	reddy	PROPN
biomedich-578	298	15	ph	ph	PROPN
biomedich-578	298	16	.	.	PROPN
biomedich-578	298	17	(	(	PUNCT
biomedich-578	298	18	2017	2017	NUM
biomedich-578	298	19	)	)	PUNCT
biomedich-578	298	20	.	.	PUNCT
biomedich-578	299	1	role	role	NOUN
biomedich-578	299	2	of	of	ADP
biomedich-578	299	3	glutamate	glutamate	NOUN
biomedich-578	299	4	and	and	CCONJ
biomedich-578	299	5	nmda	nmda	ADJ
biomedich-578	299	6	receptors	receptor	NOUN
biomedich-578	299	7	in	in	ADP
biomedich-578	299	8	alzheimer	alzheimer	PROPN
biomedich-578	299	9	's	's	PART
biomedich-578	299	10	disease	disease	NOUN
biomedich-578	299	11	.	.	PUNCT
biomedich-578	300	1	j	j	PROPN
biomedich-578	300	2	alzheimers	alzheimers	PROPN
biomedich-578	300	3	dis	dis	PROPN
biomedich-578	300	4	.	.	PUNCT
biomedich-578	301	1	57(4	57(4	NUM
biomedich-578	301	2	):	):	PUNCT
biomedich-578	301	3	1041	1041	NUM
biomedich-578	301	4	-	-	SYM
biomedich-578	301	5	1048	1048	NUM
biomedich-578	301	6	.	.	PUNCT
biomedich-578	302	1	doi	doi	NOUN
biomedich-578	302	2	:	:	PUNCT
biomedich-578	302	3	10.3233	10.3233	NUM
biomedich-578	302	4	/	/	SYM
biomedich-578	302	5	jad-160763	jad-160763	NOUN
biomedich-578	302	6	.	.	PUNCT
biomedich-578	303	1	xia	xia	PROPN
biomedich-578	303	2	y	y	PROPN
biomedich-578	303	3	,	,	PUNCT
biomedich-578	303	4	sorrentino	sorrentino	PROPN
biomedich-578	303	5	za	za	PROPN
biomedich-578	303	6	,	,	PUNCT
biomedich-578	303	7	kim	kim	PROPN
biomedich-578	303	8	jd	jd	PROPN
biomedich-578	303	9	,	,	PUNCT
biomedich-578	303	10	strang	strang	PROPN
biomedich-578	303	11	kh	kh	PROPN
biomedich-578	303	12	,	,	PUNCT
biomedich-578	303	13	riffe	riffe	PROPN
biomedich-578	303	14	cj	cj	PROPN
biomedich-578	303	15	,	,	PUNCT
biomedich-578	303	16	giasson	giasson	PROPN
biomedich-578	303	17	bi	bi	PROPN
biomedich-578	303	18	.	.	PUNCT
biomedich-578	303	19	(	(	PUNCT
biomedich-578	303	20	2019	2019	NUM
biomedich-578	303	21	)	)	PUNCT
biomedich-578	303	22	.	.	PUNCT
biomedich-578	304	1	impaired	impair	VERB
biomedich-578	304	2	tau	tau	NOUN
biomedich-578	304	3	–	–	PUNCT
biomedich-578	304	4	microtubule	microtubule	NOUN
biomedich-578	304	5	interactions	interaction	NOUN
biomedich-578	304	6	are	be	AUX
biomedich-578	304	7	prevalent	prevalent	ADJ
biomedich-578	304	8	among	among	ADP
biomedich-578	304	9	pathogenic	pathogenic	ADJ
biomedich-578	304	10	tau	tau	PROPN
biomedich-578	304	11	variants	variant	NOUN
biomedich-578	304	12	arising	arise	VERB
biomedich-578	304	13	from	from	ADP
biomedich-578	304	14	missense	missense	NOUN
biomedich-578	304	15	mutation	mutation	NOUN
biomedich-578	304	16	tau	tau	PROPN
biomedich-578	304	17	mutants	mutants	PROPN
biomedich-578	304	18	impair	impair	VERB
biomedich-578	304	19	microtubule	microtubule	NOUN
biomedich-578	304	20	interaction	interaction	NOUN
biomedich-578	304	21	.	.	PUNCT
biomedich-578	305	1	journal	journal	NOUN
biomedich-578	305	2	of	of	ADP
biomedich-578	305	3	biological	biological	ADJ
biomedich-578	305	4	chemistry	chemistry	NOUN
biomedich-578	305	5	.	.	PUNCT
biomedich-578	306	1	294	294	NUM
biomedich-578	306	2	(	(	PUNCT
biomedich-578	306	3	48	48	NUM
biomedich-578	306	4	):	):	PUNCT
biomedich-578	306	5	18488	18488	NUM
biomedich-578	306	6	-	-	SYM
biomedich-578	306	7	18503	18503	NUM
biomedich-578	306	8	.	.	PUNCT
biomedich-578	307	1	doi.org/	doi.org/	ADP
biomedich-578	307	2	10.1074	10.1074	NUM
biomedich-578	307	3	/	/	SYM
biomedich-578	307	4	jbc.ra119.010178	jbc.ra119.010178	PROPN
biomedich-578	307	5	yiannopoulou	yiannopoulou	PROPN
biomedich-578	307	6	kg	kg	PROPN
biomedich-578	307	7	,	,	PUNCT
biomedich-578	307	8	anastasiou	anastasiou	PROPN
biomedich-578	307	9	ai	ai	PROPN
biomedich-578	307	10	,	,	PUNCT
biomedich-578	307	11	zachariou	zachariou	ADJ
biomedich-578	307	12	v	v	NOUN
biomedich-578	307	13	,	,	PUNCT
biomedich-578	307	14	pelidou	pelidou	PROPN
biomedich-578	307	15	sh	sh	PROPN
biomedich-578	307	16	.	.	PUNCT
biomedich-578	307	17	(	(	PUNCT
biomedich-578	307	18	2019	2019	NUM
biomedich-578	307	19	)	)	PUNCT
biomedich-578	307	20	.	.	PUNCT
biomedich-578	308	1	reasons	reason	NOUN
biomedich-578	308	2	for	for	ADP
biomedich-578	308	3	failed	fail	VERB
biomedich-578	308	4	trials	trial	NOUN
biomedich-578	308	5	of	of	ADP
biomedich-578	308	6	disease	disease	NOUN
biomedich-578	308	7	-	-	PUNCT
biomedich-578	308	8	modifying	modify	VERB
biomedich-578	308	9	treatments	treatment	NOUN
biomedich-578	308	10	for	for	ADP
biomedich-578	308	11	alzheimer	alzheimer	NOUN
biomedich-578	308	12	disease	disease	NOUN
biomedich-578	308	13	and	and	CCONJ
biomedich-578	308	14	their	their	PRON
biomedich-578	308	15	contribution	contribution	NOUN
biomedich-578	308	16	in	in	ADP
biomedich-578	308	17	recent	recent	ADJ
biomedich-578	308	18	research	research	NOUN
biomedich-578	308	19	.	.	PUNCT
biomedich-578	309	1	biomedicines	biomedicine	NOUN
biomedich-578	309	2	,	,	PUNCT
biomedich-578	309	3	7(4):97	7(4):97	X
biomedich-578	309	4	.	.	PUNCT
biomedich-578	310	1	doi.org/10.3390/biomedicines7040097	doi.org/10.3390/biomedicines7040097	NOUN
biomedich-578	310	2	.	.	PUNCT
biomedich-578	311	1	this	this	DET
biomedich-578	311	2	page	page	NOUN
biomedich-578	311	3	intentionally	intentionally	ADV
biomedich-578	311	4	left	leave	VERB
biomedich-578	311	5	blank	blank	ADV