id	sid	tid	token	lemma	pos
biomedich-684	1	1	biology	biology	NOUN
biomedich-684	1	2	,	,	PUNCT
biomedich-684	1	3	medicine	medicine	NOUN
biomedich-684	1	4	,	,	PUNCT
biomedich-684	1	5	&	&	CCONJ
biomedich-684	1	6	natural	natural	ADJ
biomedich-684	1	7	product	product	NOUN
biomedich-684	1	8	chemistry	chemistry	NOUN
biomedich-684	1	9	issn	issn	VERB
biomedich-684	1	10	2089	2089	NUM
biomedich-684	1	11	-	-	SYM
biomedich-684	1	12	6514	6514	NUM
biomedich-684	1	13	(	(	PUNCT
biomedich-684	1	14	paper	paper	NOUN
biomedich-684	1	15	)	)	PUNCT
biomedich-684	1	16	volume	volume	NOUN
biomedich-684	1	17	14	14	NUM
biomedich-684	1	18	,	,	PUNCT
biomedich-684	1	19	number	number	NOUN
biomedich-684	1	20	1	1	NUM
biomedich-684	1	21	,	,	PUNCT
biomedich-684	1	22	april	april	PROPN
biomedich-684	1	23	2025	2025	NUM
biomedich-684	1	24	|	|	ADV
biomedich-684	1	25	pages	page	NOUN
biomedich-684	1	26	:	:	PUNCT
biomedich-684	1	27	177	177	NUM
biomedich-684	1	28	-	-	SYM
biomedich-684	1	29	184	184	NUM
biomedich-684	1	30	|	|	ADV
biomedich-684	1	31	doi	doi	NOUN
biomedich-684	1	32	:	:	PUNCT
biomedich-684	1	33	10.14421	10.14421	NUM
biomedich-684	1	34	/	/	SYM
biomedich-684	1	35	biomedich.2025.141.177	biomedich.2025.141.177	NOUN
biomedich-684	1	36	-	-	NUM
biomedich-684	1	37	184	184	NUM
biomedich-684	1	38	issn	issn	PROPN
biomedich-684	1	39	2540	2540	NUM
biomedich-684	1	40	-	-	SYM
biomedich-684	1	41	9328	9328	NUM
biomedich-684	1	42	(	(	PUNCT
biomedich-684	1	43	online	online	ADV
biomedich-684	1	44	)	)	PUNCT
biomedich-684	1	45	in	in	ADP
biomedich-684	1	46	silico	silico	NOUN
biomedich-684	1	47	analysis	analysis	NOUN
biomedich-684	1	48	of	of	ADP
biomedich-684	1	49	bioactive	bioactive	ADJ
biomedich-684	1	50	compounds	compound	NOUN
biomedich-684	1	51	in	in	ADP
biomedich-684	1	52	the	the	DET
biomedich-684	1	53	faloak	faloak	NOUN
biomedich-684	1	54	(	(	PUNCT
biomedich-684	1	55	sterculia	sterculia	PROPN
biomedich-684	1	56	quadrifida	quadrifida	PROPN
biomedich-684	1	57	r.	r.	PROPN
biomedich-684	1	58	br	br	PROPN
biomedich-684	1	59	)	)	PUNCT
biomedich-684	1	60	stem	stem	NOUN
biomedich-684	1	61	bark	bark	NOUN
biomedich-684	1	62	to	to	PART
biomedich-684	1	63	identify	identify	VERB
biomedich-684	1	64	antidiabetic	antidiabetic	ADJ
biomedich-684	1	65	activity	activity	NOUN
biomedich-684	1	66	fajar	fajar	PROPN
biomedich-684	1	67	dwi	dwi	PROPN
biomedich-684	1	68	utami	utami	PROPN
biomedich-684	1	69	,	,	PUNCT
biomedich-684	1	70	rizqi	rizqi	NOUN
biomedich-684	1	71	akbar	akbar	NOUN
biomedich-684	1	72	fandi	fandi	NOUN
biomedich-684	1	73	achmad	achmad	PROPN
biomedich-684	1	74	daud	daud	PROPN
biomedich-684	1	75	,	,	PUNCT
biomedich-684	1	76	adi	adi	PROPN
biomedich-684	1	77	nurmayati	nurmayati	PROPN
biomedich-684	1	78	,	,	PUNCT
biomedich-684	1	79	monika	monika	PROPN
biomedich-684	1	80	buka	buka	PROPN
biomedich-684	1	81	kopon	kopon	PROPN
biomedich-684	1	82	ratumakin	ratumakin	PROPN
biomedich-684	1	83	,	,	PUNCT
biomedich-684	1	84	chris	chris	PROPN
biomedich-684	1	85	nicholas	nicholas	PROPN
biomedich-684	1	86	siung	siung	PROPN
biomedich-684	1	87	,	,	PUNCT
biomedich-684	1	88	adiva	adiva	PROPN
biomedich-684	1	89	stephanie	stephanie	PROPN
biomedich-684	1	90	,	,	PUNCT
biomedich-684	1	91	almufti	almufti	VERB
biomedich-684	1	92	fadillah	fadillah	PROPN
biomedich-684	1	93	,	,	PUNCT
biomedich-684	1	94	esti	esti	PROPN
biomedich-684	1	95	mulatsari	mulatsari	PROPN
biomedich-684	1	96	,	,	PUNCT
biomedich-684	1	97	esti	esti	PROPN
biomedich-684	1	98	mumpuni	mumpuni	PROPN
biomedich-684	1	99	*	*	PROPN
biomedich-684	1	100	,	,	PUNCT
biomedich-684	1	101	andri	andri	NOUN
biomedich-684	1	102	prasetyo	prasetyo	NOUN
biomedich-684	1	103	faculty	faculty	NOUN
biomedich-684	1	104	of	of	ADP
biomedich-684	1	105	pharmacy	pharmacy	NOUN
biomedich-684	1	106	,	,	PUNCT
biomedich-684	1	107	universitas	universita	NOUN
biomedich-684	1	108	pancasila	pancasila	PROPN
biomedich-684	1	109	jl	jl	PROPN
biomedich-684	1	110	.	.	PUNCT
biomedich-684	2	1	srengseng	srengseng	PROPN
biomedich-684	2	2	sawah	sawah	PROPN
biomedich-684	2	3	,	,	PUNCT
biomedich-684	2	4	jagakarsa	jagakarsa	PROPN
biomedich-684	2	5	,	,	PUNCT
biomedich-684	2	6	jakarta	jakarta	PROPN
biomedich-684	2	7	selatan	selatan	PROPN
biomedich-684	2	8	12640	12640	NUM
biomedich-684	2	9	tel	tel	PROPN
biomedich-684	2	10	.	.	PUNCT
biomedich-684	3	1	(	(	PUNCT
biomedich-684	3	2	021	021	NUM
biomedich-684	3	3	)	)	PUNCT
biomedich-684	3	4	7864728	7864728	NUM
biomedich-684	3	5	,	,	PUNCT
biomedich-684	3	6	indonesia	indonesia	PROPN
biomedich-684	3	7	.	.	PUNCT
biomedich-684	4	1	corresponding	correspond	VERB
biomedich-684	4	2	author	author	NOUN
biomedich-684	4	3	*	*	PUNCT
biomedich-684	4	4	esti.mumpuni@univpancasila.ac.id	esti.mumpuni@univpancasila.ac.id	NUM
biomedich-684	4	5	manuscript	manuscript	NOUN
biomedich-684	4	6	received	receive	VERB
biomedich-684	4	7	:	:	PUNCT
biomedich-684	4	8	13	13	NUM
biomedich-684	4	9	january	january	PROPN
biomedich-684	4	10	,	,	PUNCT
biomedich-684	4	11	2025	2025	NUM
biomedich-684	4	12	.	.	PUNCT
biomedich-684	5	1	revision	revision	NOUN
biomedich-684	5	2	accepted	accept	VERB
biomedich-684	5	3	:	:	PUNCT
biomedich-684	5	4	15	15	NUM
biomedich-684	5	5	may	may	NOUN
biomedich-684	5	6	,	,	PUNCT
biomedich-684	5	7	2025	2025	NUM
biomedich-684	5	8	.	.	PUNCT
biomedich-684	6	1	published	publish	VERB
biomedich-684	6	2	:	:	PUNCT
biomedich-684	6	3	03	03	NUM
biomedich-684	6	4	june	june	PROPN
biomedich-684	6	5	,	,	PUNCT
biomedich-684	6	6	2025	2025	NUM
biomedich-684	6	7	.	.	PUNCT
biomedich-684	7	1	abstract	abstract	ADJ
biomedich-684	7	2	sterculia	sterculia	PROPN
biomedich-684	7	3	quadrifida	quadrifida	PROPN
biomedich-684	7	4	r.	r.	PROPN
biomedich-684	7	5	br	br	PROPN
biomedich-684	7	6	or	or	CCONJ
biomedich-684	7	7	known	know	VERB
biomedich-684	7	8	as	as	ADP
biomedich-684	7	9	the	the	DET
biomedich-684	7	10	faloak	faloak	NOUN
biomedich-684	7	11	plant	plant	NOUN
biomedich-684	7	12	is	be	AUX
biomedich-684	7	13	a	a	DET
biomedich-684	7	14	typical	typical	ADJ
biomedich-684	7	15	plant	plant	NOUN
biomedich-684	7	16	originating	originate	VERB
biomedich-684	7	17	from	from	ADP
biomedich-684	7	18	the	the	DET
biomedich-684	7	19	east	east	PROPN
biomedich-684	7	20	nusa	nusa	PROPN
biomedich-684	7	21	tenggara	tenggara	PROPN
biomedich-684	7	22	region	region	PROPN
biomedich-684	7	23	,	,	PUNCT
biomedich-684	7	24	indonesia	indonesia	PROPN
biomedich-684	7	25	.	.	PUNCT
biomedich-684	8	1	this	this	DET
biomedich-684	8	2	plant	plant	NOUN
biomedich-684	8	3	has	have	AUX
biomedich-684	8	4	long	long	ADV
biomedich-684	8	5	been	be	AUX
biomedich-684	8	6	used	use	VERB
biomedich-684	8	7	by	by	ADP
biomedich-684	8	8	local	local	ADJ
biomedich-684	8	9	people	people	NOUN
biomedich-684	8	10	in	in	ADP
biomedich-684	8	11	the	the	DET
biomedich-684	8	12	treatment	treatment	NOUN
biomedich-684	8	13	of	of	ADP
biomedich-684	8	14	diabetes	diabetes	NOUN
biomedich-684	8	15	.	.	PUNCT
biomedich-684	9	1	in	in	ADP
biomedich-684	9	2	vivo	vivo	NOUN
biomedich-684	9	3	,	,	PUNCT
biomedich-684	9	4	bioactive	bioactive	ADJ
biomedich-684	9	5	compounds	compound	NOUN
biomedich-684	9	6	from	from	ADP
biomedich-684	9	7	the	the	DET
biomedich-684	9	8	extract	extract	NOUN
biomedich-684	9	9	of	of	ADP
biomedich-684	9	10	stem	stem	NOUN
biomedich-684	9	11	bark	bark	NOUN
biomedich-684	9	12	sterculia	sterculia	NOUN
biomedich-684	9	13	quadrifida	quadrifida	PROPN
biomedich-684	9	14	r.	r.	PROPN
biomedich-684	9	15	br	br	PROPN
biomedich-684	9	16	have	have	AUX
biomedich-684	9	17	been	be	AUX
biomedich-684	9	18	reported	report	VERB
biomedich-684	9	19	to	to	PART
biomedich-684	9	20	have	have	VERB
biomedich-684	9	21	antidiabetic	antidiabetic	ADJ
biomedich-684	9	22	activity	activity	NOUN
biomedich-684	9	23	.	.	PUNCT
biomedich-684	10	1	the	the	DET
biomedich-684	10	2	present	present	ADJ
biomedich-684	10	3	study	study	NOUN
biomedich-684	10	4	aims	aim	VERB
biomedich-684	10	5	to	to	PART
biomedich-684	10	6	analyse	analyse	VERB
biomedich-684	10	7	the	the	DET
biomedich-684	10	8	potential	potential	NOUN
biomedich-684	10	9	of	of	ADP
biomedich-684	10	10	bioactive	bioactive	ADJ
biomedich-684	10	11	compounds	compound	NOUN
biomedich-684	10	12	in	in	ADP
biomedich-684	10	13	the	the	DET
biomedich-684	10	14	faloak	faloak	NOUN
biomedich-684	10	15	stem	stem	NOUN
biomedich-684	10	16	bark	bark	NOUN
biomedich-684	10	17	as	as	ADP
biomedich-684	10	18	inhibitors	inhibitor	NOUN
biomedich-684	10	19	of	of	ADP
biomedich-684	10	20	the	the	DET
biomedich-684	10	21	enzymes	enzyme	NOUN
biomedich-684	10	22	α	α	NOUN
biomedich-684	10	23	-	-	PUNCT
biomedich-684	10	24	glucosidase	glucosidase	ADJ
biomedich-684	10	25	,	,	PUNCT
biomedich-684	10	26	ppar	ppar	NOUN
biomedich-684	10	27	-	-	PUNCT
biomedich-684	10	28	γ	γ	NOUN
biomedich-684	10	29	,	,	PUNCT
biomedich-684	10	30	sglt2	sglt2	NOUN
biomedich-684	10	31	,	,	PUNCT
biomedich-684	10	32	and	and	CCONJ
biomedich-684	10	33	dpp	dpp	NOUN
biomedich-684	10	34	-	-	PUNCT
biomedich-684	10	35	iv	iv	NOUN
biomedich-684	10	36	.	.	PUNCT
biomedich-684	11	1	the	the	DET
biomedich-684	11	2	preparation	preparation	NOUN
biomedich-684	11	3	of	of	ADP
biomedich-684	11	4	bioactive	bioactive	ADJ
biomedich-684	11	5	compounds	compound	NOUN
biomedich-684	11	6	and	and	CCONJ
biomedich-684	11	7	their	their	PRON
biomedich-684	11	8	comparison	comparison	NOUN
biomedich-684	11	9	was	be	AUX
biomedich-684	11	10	conducted	conduct	VERB
biomedich-684	11	11	utilising	utilise	VERB
biomedich-684	11	12	chemdraw	chemdraw	NOUN
biomedich-684	11	13	2d	2d	PROPN
biomedich-684	11	14	&	&	CCONJ
biomedich-684	11	15	3d	3d	NUM
biomedich-684	11	16	,	,	PUNCT
biomedich-684	11	17	while	while	SCONJ
biomedich-684	11	18	proteins	protein	NOUN
biomedich-684	11	19	were	be	AUX
biomedich-684	11	20	obtained	obtain	VERB
biomedich-684	11	21	from	from	ADP
biomedich-684	11	22	the	the	DET
biomedich-684	11	23	protein	protein	NOUN
biomedich-684	11	24	data	data	PROPN
biomedich-684	11	25	bank	bank	PROPN
biomedich-684	11	26	(	(	PUNCT
biomedich-684	11	27	pdb	pdb	PROPN
biomedich-684	11	28	)	)	PUNCT
biomedich-684	11	29	.	.	PUNCT
biomedich-684	12	1	the	the	DET
biomedich-684	12	2	docking	docking	NOUN
biomedich-684	12	3	process	process	NOUN
biomedich-684	12	4	used	use	VERB
biomedich-684	12	5	molegro	molegro	ADJ
biomedich-684	12	6	virtual	virtual	ADJ
biomedich-684	12	7	docker	docker	PROPN
biomedich-684	12	8	,	,	PUNCT
biomedich-684	12	9	and	and	CCONJ
biomedich-684	12	10	visualisation	visualisation	NOUN
biomedich-684	12	11	was	be	AUX
biomedich-684	12	12	performed	perform	VERB
biomedich-684	12	13	using	use	VERB
biomedich-684	12	14	biovia	biovia	PROPN
biomedich-684	12	15	discovery	discovery	PROPN
biomedich-684	12	16	studio	studio	NOUN
biomedich-684	12	17	.	.	PUNCT
biomedich-684	13	1	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	13	2	prediction	prediction	NOUN
biomedich-684	13	3	(	(	PUNCT
biomedich-684	13	4	admet	admet	PROPN
biomedich-684	13	5	)	)	PUNCT
biomedich-684	13	6	was	be	AUX
biomedich-684	13	7	also	also	ADV
biomedich-684	13	8	carried	carry	VERB
biomedich-684	13	9	out	out	ADP
biomedich-684	13	10	using	use	VERB
biomedich-684	13	11	the	the	DET
biomedich-684	13	12	pkcsm	pkcsm	NOUN
biomedich-684	13	13	website	website	NOUN
biomedich-684	13	14	.	.	PUNCT
biomedich-684	14	1	the	the	DET
biomedich-684	14	2	results	result	NOUN
biomedich-684	14	3	of	of	ADP
biomedich-684	14	4	molecular	molecular	ADJ
biomedich-684	14	5	docking	docking	NOUN
biomedich-684	14	6	with	with	ADP
biomedich-684	14	7	dpp	dpp	NOUN
biomedich-684	14	8	-	-	PUNCT
biomedich-684	14	9	iv	iv	NUM
biomedich-684	14	10	receptors	receptor	NOUN
biomedich-684	14	11	showed	show	VERB
biomedich-684	14	12	that	that	SCONJ
biomedich-684	14	13	three	three	NUM
biomedich-684	14	14	bioactive	bioactive	ADJ
biomedich-684	14	15	compounds	compound	NOUN
biomedich-684	14	16	of	of	ADP
biomedich-684	14	17	faloak	faloak	NOUN
biomedich-684	14	18	have	have	VERB
biomedich-684	14	19	better	well	ADJ
biomedich-684	14	20	affinity	affinity	NOUN
biomedich-684	14	21	than	than	ADP
biomedich-684	14	22	the	the	DET
biomedich-684	14	23	comparative	comparative	ADJ
biomedich-684	14	24	compounds	compound	NOUN
biomedich-684	14	25	,	,	PUNCT
biomedich-684	14	26	namely	namely	ADV
biomedich-684	14	27	beta	beta	ADJ
biomedich-684	14	28	sisterol	sisterol	NOUN
biomedich-684	14	29	(	(	PUNCT
biomedich-684	14	30	-98.8838	-98.8838	INTJ
biomedich-684	14	31	)	)	PUNCT
biomedich-684	14	32	to	to	ADP
biomedich-684	14	33	alogliptin	alogliptin	NOUN
biomedich-684	14	34	,	,	PUNCT
biomedich-684	14	35	linagliptin	linagliptin	ADJ
biomedich-684	14	36	,	,	PUNCT
biomedich-684	14	37	and	and	CCONJ
biomedich-684	14	38	sitagliptin	sitagliptin	NOUN
biomedich-684	14	39	.	.	PUNCT
biomedich-684	15	1	while	while	SCONJ
biomedich-684	15	2	epicatechin	epicatechin	NOUN
biomedich-684	15	3	(	(	PUNCT
biomedich-684	15	4	-83.9022	-83.9022	PUNCT
biomedich-684	15	5	)	)	PUNCT
biomedich-684	15	6	and	and	CCONJ
biomedich-684	15	7	cathecin	cathecin	PROPN
biomedich-684	15	8	(	(	PUNCT
biomedich-684	15	9	-83.4336	-83.4336	CCONJ
biomedich-684	15	10	)	)	PUNCT
biomedich-684	15	11	have	have	VERB
biomedich-684	15	12	better	well	ADJ
biomedich-684	15	13	affinity	affinity	NOUN
biomedich-684	15	14	than	than	SCONJ
biomedich-684	15	15	the	the	DET
biomedich-684	15	16	comparative	comparative	ADJ
biomedich-684	15	17	compounds	compound	VERB
biomedich-684	15	18	vidagliptin	vidagliptin	ADJ
biomedich-684	15	19	,	,	PUNCT
biomedich-684	15	20	saxagliptin	saxagliptin	NOUN
biomedich-684	15	21	.	.	PUNCT
biomedich-684	16	1	keywords	keyword	NOUN
biomedich-684	16	2	:	:	PUNCT
biomedich-684	16	3	antidiabetic	antidiabetic	ADJ
biomedich-684	16	4	;	;	PUNCT
biomedich-684	16	5	faloak	faloak	NOUN
biomedich-684	16	6	stem	stem	NOUN
biomedich-684	16	7	bark	bark	NOUN
biomedich-684	16	8	;	;	PUNCT
biomedich-684	16	9	molecular	molecular	ADJ
biomedich-684	16	10	docking	docking	NOUN
biomedich-684	16	11	;	;	PUNCT
biomedich-684	16	12	in	in	ADP
biomedich-684	16	13	silico	silico	NOUN
biomedich-684	16	14	;	;	PUNCT
biomedich-684	16	15	sterculia	sterculia	PROPN
biomedich-684	16	16	quadrifida	quadrifida	PROPN
biomedich-684	16	17	r.	r.	PROPN
biomedich-684	16	18	br	br	PROPN
biomedich-684	16	19	.	.	PUNCT
biomedich-684	16	20	introduction	introduction	NOUN
biomedich-684	16	21	diabetes	diabetes	NOUN
biomedich-684	16	22	mellitus	mellitus	NOUN
biomedich-684	16	23	(	(	PUNCT
biomedich-684	16	24	dm	dm	PROPN
biomedich-684	16	25	)	)	PUNCT
biomedich-684	16	26	is	be	AUX
biomedich-684	16	27	a	a	DET
biomedich-684	16	28	chronic	chronic	ADJ
biomedich-684	16	29	metabolic	metabolic	NOUN
biomedich-684	16	30	disease	disease	NOUN
biomedich-684	16	31	whose	whose	DET
biomedich-684	16	32	prevalence	prevalence	NOUN
biomedich-684	16	33	continues	continue	VERB
biomedich-684	16	34	to	to	PART
biomedich-684	16	35	increase	increase	VERB
biomedich-684	16	36	globally	globally	ADV
biomedich-684	16	37	.	.	PUNCT
biomedich-684	17	1	based	base	VERB
biomedich-684	17	2	on	on	ADP
biomedich-684	17	3	data	datum	NOUN
biomedich-684	17	4	from	from	ADP
biomedich-684	17	5	the	the	DET
biomedich-684	17	6	international	international	PROPN
biomedich-684	17	7	data	data	PROPN
biomedich-684	17	8	federation	federation	PROPN
biomedich-684	17	9	(	(	PUNCT
biomedich-684	17	10	idf	idf	PROPN
biomedich-684	17	11	)	)	PUNCT
biomedich-684	17	12	,	,	PUNCT
biomedich-684	17	13	in	in	ADP
biomedich-684	17	14	2021	2021	NUM
biomedich-684	17	15	,	,	PUNCT
biomedich-684	17	16	there	there	PRON
biomedich-684	17	17	were	be	VERB
biomedich-684	17	18	around	around	ADV
biomedich-684	17	19	537	537	NUM
biomedich-684	17	20	people	people	NOUN
biomedich-684	17	21	worldwide	worldwide	ADV
biomedich-684	17	22	with	with	ADP
biomedich-684	17	23	diabetes	diabetes	NOUN
biomedich-684	17	24	.	.	PUNCT
biomedich-684	18	1	this	this	DET
biomedich-684	18	2	number	number	NOUN
biomedich-684	18	3	is	be	AUX
biomedich-684	18	4	predicted	predict	VERB
biomedich-684	18	5	to	to	PART
biomedich-684	18	6	increase	increase	VERB
biomedich-684	18	7	to	to	ADP
biomedich-684	18	8	643	643	NUM
biomedich-684	18	9	million	million	NUM
biomedich-684	18	10	in	in	ADP
biomedich-684	18	11	2030	2030	NUM
biomedich-684	18	12	and	and	CCONJ
biomedich-684	18	13	783	783	NUM
biomedich-684	18	14	million	million	NUM
biomedich-684	18	15	in	in	ADP
biomedich-684	18	16	2045	2045	NUM
biomedich-684	18	17	.	.	PUNCT
biomedich-684	19	1	according	accord	VERB
biomedich-684	19	2	to	to	ADP
biomedich-684	19	3	the	the	DET
biomedich-684	19	4	idf	idf	PROPN
biomedich-684	19	5	,	,	PUNCT
biomedich-684	19	6	indonesia	indonesia	PROPN
biomedich-684	19	7	is	be	AUX
biomedich-684	19	8	the	the	DET
biomedich-684	19	9	fifth	fifth	ADJ
biomedich-684	19	10	country	country	NOUN
biomedich-684	19	11	with	with	ADP
biomedich-684	19	12	the	the	DET
biomedich-684	19	13	highest	high	ADJ
biomedich-684	19	14	number	number	NOUN
biomedich-684	19	15	of	of	ADP
biomedich-684	19	16	diabetes	diabetes	NOUN
biomedich-684	19	17	with	with	ADP
biomedich-684	19	18	19.5	19.5	NUM
biomedich-684	19	19	million	million	NUM
biomedich-684	19	20	sufferers	sufferer	NOUN
biomedich-684	19	21	in	in	ADP
biomedich-684	19	22	2021	2021	NUM
biomedich-684	19	23	and	and	CCONJ
biomedich-684	19	24	is	be	AUX
biomedich-684	19	25	predicted	predict	VERB
biomedich-684	19	26	to	to	PART
biomedich-684	19	27	be	be	AUX
biomedich-684	19	28	28.6	28.6	NUM
biomedich-684	19	29	million	million	NUM
biomedich-684	19	30	in	in	ADP
biomedich-684	19	31	2045	2045	NUM
biomedich-684	19	32	.	.	PUNCT
biomedich-684	20	1	the	the	DET
biomedich-684	20	2	world	world	PROPN
biomedich-684	20	3	health	health	PROPN
biomedich-684	20	4	organization	organization	NOUN
biomedich-684	20	5	(	(	PUNCT
biomedich-684	20	6	who	who	PRON
biomedich-684	20	7	)	)	PUNCT
biomedich-684	20	8	states	state	VERB
biomedich-684	20	9	that	that	SCONJ
biomedich-684	20	10	diabetes	diabetes	NOUN
biomedich-684	20	11	is	be	AUX
biomedich-684	20	12	one	one	NUM
biomedich-684	20	13	of	of	ADP
biomedich-684	20	14	the	the	DET
biomedich-684	20	15	diseases	disease	NOUN
biomedich-684	20	16	in	in	ADP
biomedich-684	20	17	indonesia	indonesia	PROPN
biomedich-684	20	18	that	that	PRON
biomedich-684	20	19	causes	cause	VERB
biomedich-684	20	20	death	death	NOUN
biomedich-684	20	21	.	.	PUNCT
biomedich-684	21	1	diabetes	diabetes	NOUN
biomedich-684	21	2	can	can	AUX
biomedich-684	21	3	trigger	trigger	VERB
biomedich-684	21	4	other	other	ADJ
biomedich-684	21	5	diseases	disease	NOUN
biomedich-684	21	6	(	(	PUNCT
biomedich-684	21	7	asyikin	asyikin	PROPN
biomedich-684	21	8	&	&	CCONJ
biomedich-684	21	9	ratnasari	ratnasari	PROPN
biomedich-684	21	10	dewi	dewi	PROPN
biomedich-684	21	11	poltekkes	poltekke	VERB
biomedich-684	21	12	kemenkes	kemenkes	PROPN
biomedich-684	21	13	makassar	makassar	PROPN
biomedich-684	21	14	,	,	PUNCT
biomedich-684	21	15	2024	2024	NUM
biomedich-684	21	16	)	)	PUNCT
biomedich-684	21	17	.	.	PUNCT
biomedich-684	22	1	one	one	NUM
biomedich-684	22	2	of	of	ADP
biomedich-684	22	3	the	the	DET
biomedich-684	22	4	causes	cause	NOUN
biomedich-684	22	5	of	of	ADP
biomedich-684	22	6	the	the	DET
biomedich-684	22	7	high	high	ADJ
biomedich-684	22	8	prevalence	prevalence	NOUN
biomedich-684	22	9	of	of	ADP
biomedich-684	22	10	diabetes	diabetes	NOUN
biomedich-684	22	11	is	be	AUX
biomedich-684	22	12	an	an	DET
biomedich-684	22	13	unhealthy	unhealthy	ADJ
biomedich-684	22	14	diet	diet	NOUN
biomedich-684	22	15	and	and	CCONJ
biomedich-684	22	16	lifestyle	lifestyle	NOUN
biomedich-684	22	17	.	.	PUNCT
biomedich-684	23	1	with	with	ADP
biomedich-684	23	2	the	the	DET
biomedich-684	23	3	increasing	increase	VERB
biomedich-684	23	4	number	number	NOUN
biomedich-684	23	5	of	of	ADP
biomedich-684	23	6	diabetics	diabetic	NOUN
biomedich-684	23	7	in	in	ADP
biomedich-684	23	8	indonesia	indonesia	PROPN
biomedich-684	23	9	every	every	DET
biomedich-684	23	10	year	year	NOUN
biomedich-684	23	11	,	,	PUNCT
biomedich-684	23	12	two	two	NUM
biomedich-684	23	13	steps	step	NOUN
biomedich-684	23	14	can	can	AUX
biomedich-684	23	15	be	be	AUX
biomedich-684	23	16	taken	take	VERB
biomedich-684	23	17	,	,	PUNCT
biomedich-684	23	18	namely	namely	ADV
biomedich-684	23	19	the	the	DET
biomedich-684	23	20	treatment	treatment	NOUN
biomedich-684	23	21	of	of	ADP
biomedich-684	23	22	patients	patient	NOUN
biomedich-684	23	23	who	who	PRON
biomedich-684	23	24	have	have	VERB
biomedich-684	23	25	diabetes	diabetes	NOUN
biomedich-684	23	26	and	and	CCONJ
biomedich-684	23	27	prevention	prevention	NOUN
biomedich-684	23	28	of	of	ADP
biomedich-684	23	29	diabetes	diabetes	NOUN
biomedich-684	23	30	for	for	ADP
biomedich-684	23	31	those	those	PRON
biomedich-684	23	32	who	who	PRON
biomedich-684	23	33	have	have	AUX
biomedich-684	23	34	not	not	PART
biomedich-684	23	35	experienced	experience	VERB
biomedich-684	23	36	it	it	PRON
biomedich-684	23	37	.	.	PUNCT
biomedich-684	24	1	treatment	treatment	NOUN
biomedich-684	24	2	of	of	ADP
biomedich-684	24	3	diabetes	diabetes	NOUN
biomedich-684	24	4	can	can	AUX
biomedich-684	24	5	be	be	AUX
biomedich-684	24	6	done	do	VERB
biomedich-684	24	7	with	with	ADP
biomedich-684	24	8	two	two	NUM
biomedich-684	24	9	types	type	NOUN
biomedich-684	24	10	of	of	ADP
biomedich-684	24	11	treatments	treatment	NOUN
biomedich-684	24	12	,	,	PUNCT
biomedich-684	24	13	namely	namely	ADV
biomedich-684	24	14	the	the	DET
biomedich-684	24	15	provision	provision	NOUN
biomedich-684	24	16	of	of	ADP
biomedich-684	24	17	drug	drug	NOUN
biomedich-684	24	18	therapy	therapy	NOUN
biomedich-684	24	19	and	and	CCONJ
biomedich-684	24	20	non	non	ADJ
biomedich-684	24	21	-	-	ADJ
biomedich-684	24	22	drug	drug	ADJ
biomedich-684	24	23	therapy	therapy	NOUN
biomedich-684	24	24	.	.	PUNCT
biomedich-684	25	1	the	the	DET
biomedich-684	25	2	treatment	treatment	NOUN
biomedich-684	25	3	is	be	AUX
biomedich-684	25	4	not	not	PART
biomedich-684	25	5	only	only	ADV
biomedich-684	25	6	focused	focus	VERB
biomedich-684	25	7	on	on	ADP
biomedich-684	25	8	the	the	DET
biomedich-684	25	9	control	control	NOUN
biomedich-684	25	10	of	of	ADP
biomedich-684	25	11	blood	blood	NOUN
biomedich-684	25	12	glucose	glucose	NOUN
biomedich-684	25	13	levels	level	NOUN
biomedich-684	25	14	,	,	PUNCT
biomedich-684	25	15	but	but	CCONJ
biomedich-684	25	16	also	also	ADV
biomedich-684	25	17	involves	involve	VERB
biomedich-684	25	18	the	the	DET
biomedich-684	25	19	management	management	NOUN
biomedich-684	25	20	of	of	ADP
biomedich-684	25	21	disease	disease	NOUN
biomedich-684	25	22	complications	complication	NOUN
biomedich-684	25	23	and	and	CCONJ
biomedich-684	25	24	the	the	DET
biomedich-684	25	25	use	use	NOUN
biomedich-684	25	26	of	of	ADP
biomedich-684	25	27	safer	safe	ADJ
biomedich-684	25	28	and	and	CCONJ
biomedich-684	25	29	more	more	ADV
biomedich-684	25	30	efficient	efficient	ADJ
biomedich-684	25	31	therapies	therapy	NOUN
biomedich-684	25	32	(	(	PUNCT
biomedich-684	25	33	asyikin	asyikin	PROPN
biomedich-684	25	34	&	&	CCONJ
biomedich-684	25	35	ratnasari	ratnasari	PROPN
biomedich-684	25	36	dewi	dewi	PROPN
biomedich-684	25	37	poltekkes	poltekke	VERB
biomedich-684	25	38	kemenkes	kemenkes	PROPN
biomedich-684	25	39	makassar	makassar	PROPN
biomedich-684	25	40	,	,	PUNCT
biomedich-684	25	41	2024	2024	NUM
biomedich-684	25	42	)	)	PUNCT
biomedich-684	25	43	.	.	PUNCT
biomedich-684	26	1	nowadays	nowadays	ADV
biomedich-684	26	2	,	,	PUNCT
biomedich-684	26	3	people	people	NOUN
biomedich-684	26	4	tend	tend	VERB
biomedich-684	26	5	to	to	PART
biomedich-684	26	6	choose	choose	VERB
biomedich-684	26	7	treatment	treatment	NOUN
biomedich-684	26	8	by	by	ADP
biomedich-684	26	9	utilising	utilise	VERB
biomedich-684	26	10	natural	natural	ADJ
biomedich-684	26	11	products	product	NOUN
biomedich-684	26	12	as	as	ADP
biomedich-684	26	13	traditional	traditional	ADJ
biomedich-684	26	14	medicine	medicine	NOUN
biomedich-684	26	15	based	base	VERB
biomedich-684	26	16	on	on	ADP
biomedich-684	26	17	experiences	experience	NOUN
biomedich-684	26	18	passed	pass	VERB
biomedich-684	26	19	down	down	ADP
biomedich-684	26	20	from	from	ADP
biomedich-684	26	21	generation	generation	NOUN
biomedich-684	26	22	to	to	ADP
biomedich-684	26	23	generation	generation	NOUN
biomedich-684	26	24	.	.	PUNCT
biomedich-684	27	1	moreover	moreover	ADV
biomedich-684	27	2	,	,	PUNCT
biomedich-684	27	3	indonesia	indonesia	PROPN
biomedich-684	27	4	is	be	AUX
biomedich-684	27	5	a	a	DET
biomedich-684	27	6	tropical	tropical	ADJ
biomedich-684	27	7	country	country	NOUN
biomedich-684	27	8	,	,	PUNCT
biomedich-684	27	9	with	with	ADP
biomedich-684	27	10	rich	rich	ADJ
biomedich-684	27	11	biodiversity	biodiversity	NOUN
biomedich-684	27	12	in	in	ADP
biomedich-684	27	13	each	each	DET
biomedich-684	27	14	region	region	NOUN
biomedich-684	27	15	.	.	PUNCT
biomedich-684	28	1	one	one	NUM
biomedich-684	28	2	of	of	ADP
biomedich-684	28	3	the	the	DET
biomedich-684	28	4	potential	potential	ADJ
biomedich-684	28	5	plants	plant	NOUN
biomedich-684	28	6	in	in	ADP
biomedich-684	28	7	the	the	DET
biomedich-684	28	8	treatment	treatment	NOUN
biomedich-684	28	9	of	of	ADP
biomedich-684	28	10	diabetes	diabetes	NOUN
biomedich-684	28	11	is	be	AUX
biomedich-684	28	12	the	the	DET
biomedich-684	28	13	faloak	faloak	NOUN
biomedich-684	28	14	plant	plant	NOUN
biomedich-684	28	15	(	(	PUNCT
biomedich-684	28	16	sterculia	sterculia	PROPN
biomedich-684	28	17	quadrifida	quadrifida	PROPN
biomedich-684	28	18	r.	r.	PROPN
biomedich-684	28	19	br	br	PROPN
biomedich-684	28	20	)	)	PUNCT
biomedich-684	28	21	,	,	PUNCT
biomedich-684	28	22	which	which	PRON
biomedich-684	28	23	has	have	AUX
biomedich-684	28	24	long	long	ADV
biomedich-684	28	25	been	be	AUX
biomedich-684	28	26	used	use	VERB
biomedich-684	28	27	by	by	ADP
biomedich-684	28	28	local	local	ADJ
biomedich-684	28	29	people	people	NOUN
biomedich-684	28	30	as	as	ADP
biomedich-684	28	31	a	a	DET
biomedich-684	28	32	traditional	traditional	ADJ
biomedich-684	28	33	treatment	treatment	NOUN
biomedich-684	28	34	for	for	ADP
biomedich-684	28	35	diabetes	diabetes	NOUN
biomedich-684	28	36	on	on	ADP
biomedich-684	28	37	the	the	DET
biomedich-684	28	38	island	island	NOUN
biomedich-684	28	39	of	of	ADP
biomedich-684	28	40	timor	timor	PROPN
biomedich-684	28	41	,	,	PUNCT
biomedich-684	28	42	east	east	PROPN
biomedich-684	28	43	nusa	nusa	PROPN
biomedich-684	28	44	tenggara	tenggara	PROPN
biomedich-684	28	45	(	(	PUNCT
biomedich-684	28	46	ntt	ntt	PROPN
biomedich-684	28	47	)	)	PUNCT
biomedich-684	28	48	(	(	PUNCT
biomedich-684	28	49	octaviany	octaviany	NOUN
biomedich-684	28	50	&	&	CCONJ
biomedich-684	28	51	iskandar	iskandar	PROPN
biomedich-684	28	52	,	,	PUNCT
biomedich-684	28	53	2023	2023	NUM
biomedich-684	28	54	)	)	PUNCT
biomedich-684	28	55	.	.	PUNCT
biomedich-684	29	1	faloak	faloak	PROPN
biomedich-684	29	2	has	have	VERB
biomedich-684	29	3	many	many	ADJ
biomedich-684	29	4	chemical	chemical	ADJ
biomedich-684	29	5	compounds	compound	NOUN
biomedich-684	29	6	,	,	PUNCT
biomedich-684	29	7	including	include	VERB
biomedich-684	29	8	flavonoids	flavonoid	NOUN
biomedich-684	29	9	,	,	PUNCT
biomedich-684	29	10	tannins	tannin	NOUN
biomedich-684	29	11	,	,	PUNCT
biomedich-684	29	12	alkaloids	alkaloid	NOUN
biomedich-684	29	13	,	,	PUNCT
biomedich-684	29	14	steroids	steroid	NOUN
biomedich-684	29	15	,	,	PUNCT
biomedich-684	29	16	and	and	CCONJ
biomedich-684	29	17	triterpenoids	triterpenoids	PROPN
biomedich-684	29	18	.	.	PUNCT
biomedich-684	30	1	local	local	ADJ
biomedich-684	30	2	people	people	NOUN
biomedich-684	30	3	often	often	ADV
biomedich-684	30	4	utilize	utilize	VERB
biomedich-684	30	5	faloak	faloak	NOUN
biomedich-684	30	6	as	as	ADP
biomedich-684	30	7	a	a	DET
biomedich-684	30	8	raw	raw	ADJ
biomedich-684	30	9	material	material	NOUN
biomedich-684	30	10	for	for	ADP
biomedich-684	30	11	herbal	herbal	ADJ
biomedich-684	30	12	medicines	medicine	NOUN
biomedich-684	30	13	,	,	PUNCT
biomedich-684	30	14	and	and	CCONJ
biomedich-684	30	15	the	the	DET
biomedich-684	30	16	part	part	NOUN
biomedich-684	30	17	that	that	PRON
biomedich-684	30	18	is	be	AUX
biomedich-684	30	19	often	often	ADV
biomedich-684	30	20	used	use	VERB
biomedich-684	30	21	is	be	AUX
biomedich-684	30	22	the	the	DET
biomedich-684	30	23	stem	stem	NOUN
biomedich-684	30	24	bark	bark	NOUN
biomedich-684	30	25	which	which	PRON
biomedich-684	30	26	has	have	AUX
biomedich-684	30	27	been	be	AUX
biomedich-684	30	28	proven	prove	VERB
biomedich-684	30	29	by	by	ADP
biomedich-684	30	30	several	several	ADJ
biomedich-684	30	31	studies	study	NOUN
biomedich-684	30	32	conducted	conduct	VERB
biomedich-684	30	33	.	.	PUNCT
biomedich-684	31	1	however	however	ADV
biomedich-684	31	2	,	,	PUNCT
biomedich-684	31	3	the	the	DET
biomedich-684	31	4	bioactive	bioactive	ADJ
biomedich-684	31	5	compounds	compound	NOUN
biomedich-684	31	6	and	and	CCONJ
biomedich-684	31	7	pharmacological	pharmacological	ADJ
biomedich-684	31	8	activities	activity	NOUN
biomedich-684	31	9	of	of	ADP
biomedich-684	31	10	faloak	faloak	NOUN
biomedich-684	31	11	plants	plant	NOUN
biomedich-684	31	12	are	be	AUX
biomedich-684	31	13	still	still	ADV
biomedich-684	31	14	very	very	ADV
biomedich-684	31	15	limited	limited	ADJ
biomedich-684	31	16	due	due	ADP
biomedich-684	31	17	to	to	ADP
biomedich-684	31	18	the	the	DET
biomedich-684	31	19	lack	lack	NOUN
biomedich-684	31	20	of	of	ADP
biomedich-684	31	21	scientific	scientific	ADJ
biomedich-684	31	22	research	research	NOUN
biomedich-684	31	23	and	and	CCONJ
biomedich-684	31	24	knowledge	knowledge	NOUN
biomedich-684	31	25	(	(	PUNCT
biomedich-684	31	26	octaviany	octaviany	NOUN
biomedich-684	31	27	&	&	CCONJ
biomedich-684	31	28	iskandar	iskandar	PROPN
biomedich-684	31	29	,	,	PUNCT
biomedich-684	31	30	2023	2023	NUM
biomedich-684	31	31	)	)	PUNCT
biomedich-684	31	32	.	.	PUNCT
biomedich-684	32	1	as	as	ADP
biomedich-684	32	2	a	a	DET
biomedich-684	32	3	first	first	ADJ
biomedich-684	32	4	step	step	NOUN
biomedich-684	32	5	https://doi.org/10.14421/biomedich.2025.141.177-184	https://doi.org/10.14421/biomedich.2025.141.177-184	ADP
biomedich-684	32	6	mailto:esti.mulatsari@univpancasila.ac.id	mailto:esti.mulatsari@univpancasila.ac.id	X
biomedich-684	32	7	178	178	NUM
biomedich-684	32	8	biology	biology	NOUN
biomedich-684	32	9	,	,	PUNCT
biomedich-684	32	10	medicine	medicine	NOUN
biomedich-684	32	11	,	,	PUNCT
biomedich-684	32	12	&	&	CCONJ
biomedich-684	32	13	natural	natural	ADJ
biomedich-684	32	14	product	product	NOUN
biomedich-684	32	15	chemistry	chemistry	NOUN
biomedich-684	32	16	14	14	NUM
biomedich-684	32	17	(	(	PUNCT
biomedich-684	32	18	1	1	NUM
biomedich-684	32	19	)	)	PUNCT
biomedich-684	32	20	,	,	PUNCT
biomedich-684	32	21	2025	2025	NUM
biomedich-684	32	22	:	:	PUNCT
biomedich-684	32	23	177	177	NUM
biomedich-684	32	24	-	-	SYM
biomedich-684	32	25	184	184	NUM
biomedich-684	32	26	in	in	ADP
biomedich-684	32	27	predicting	predict	VERB
biomedich-684	32	28	the	the	DET
biomedich-684	32	29	activity	activity	NOUN
biomedich-684	32	30	of	of	ADP
biomedich-684	32	31	bioactive	bioactive	ADJ
biomedich-684	32	32	compounds	compound	NOUN
biomedich-684	32	33	in	in	ADP
biomedich-684	32	34	a	a	DET
biomedich-684	32	35	plant	plant	NOUN
biomedich-684	32	36	,	,	PUNCT
biomedich-684	32	37	a	a	DET
biomedich-684	32	38	molecular	molecular	ADJ
biomedich-684	32	39	docking	docking	NOUN
biomedich-684	32	40	approach	approach	NOUN
biomedich-684	32	41	can	can	AUX
biomedich-684	32	42	be	be	AUX
biomedich-684	32	43	used	use	VERB
biomedich-684	32	44	.	.	PUNCT
biomedich-684	33	1	according	accord	VERB
biomedich-684	33	2	to	to	ADP
biomedich-684	33	3	fernandez	fernandez	PROPN
biomedich-684	33	4	,	,	PUNCT
biomedich-684	33	5	et	et	PROPN
biomedich-684	33	6	al	al	PROPN
biomedich-684	33	7	.	.	PUNCT
biomedich-684	34	1	(	(	PUNCT
biomedich-684	34	2	2017	2017	NUM
biomedich-684	34	3	)	)	PUNCT
biomedich-684	34	4	,	,	PUNCT
biomedich-684	34	5	stated	state	VERB
biomedich-684	34	6	that	that	SCONJ
biomedich-684	34	7	the	the	DET
biomedich-684	34	8	stem	stem	NOUN
biomedich-684	34	9	bark	bark	NOUN
biomedich-684	34	10	of	of	ADP
biomedich-684	34	11	the	the	DET
biomedich-684	34	12	faloak	faloak	NOUN
biomedich-684	34	13	plant	plant	NOUN
biomedich-684	34	14	has	have	VERB
biomedich-684	34	15	antidiabetic	antidiabetic	ADJ
biomedich-684	34	16	activity	activity	NOUN
biomedich-684	34	17	by	by	ADP
biomedich-684	34	18	showing	show	VERB
biomedich-684	34	19	a	a	DET
biomedich-684	34	20	decrease	decrease	NOUN
biomedich-684	34	21	in	in	ADP
biomedich-684	34	22	blood	blood	NOUN
biomedich-684	34	23	glucose	glucose	NOUN
biomedich-684	34	24	in	in	ADP
biomedich-684	34	25	glucose	glucose	NOUN
biomedich-684	34	26	-	-	PUNCT
biomedich-684	34	27	induced	induce	VERB
biomedich-684	34	28	test	test	NOUN
biomedich-684	34	29	animals	animal	NOUN
biomedich-684	34	30	(	(	PUNCT
biomedich-684	34	31	in	in	ADP
biomedich-684	34	32	vivo	vivo	NOUN
biomedich-684	34	33	)	)	PUNCT
biomedich-684	34	34	.	.	PUNCT
biomedich-684	35	1	fernandez	fernandez	PROPN
biomedich-684	35	2	added	add	VERB
biomedich-684	35	3	that	that	SCONJ
biomedich-684	35	4	further	further	ADJ
biomedich-684	35	5	research	research	NOUN
biomedich-684	35	6	is	be	AUX
biomedich-684	35	7	needed	need	VERB
biomedich-684	35	8	to	to	PART
biomedich-684	35	9	determine	determine	VERB
biomedich-684	35	10	the	the	DET
biomedich-684	35	11	levels	level	NOUN
biomedich-684	35	12	of	of	ADP
biomedich-684	35	13	active	active	ADJ
biomedich-684	35	14	compounds	compound	NOUN
biomedich-684	35	15	in	in	ADP
biomedich-684	35	16	faloak	faloak	NOUN
biomedich-684	35	17	bark	bark	NOUN
biomedich-684	35	18	and	and	CCONJ
biomedich-684	35	19	further	far	ADV
biomedich-684	35	20	explore	explore	VERB
biomedich-684	35	21	its	its	PRON
biomedich-684	35	22	profile	profile	NOUN
biomedich-684	35	23	and	and	CCONJ
biomedich-684	35	24	safety	safety	NOUN
biomedich-684	35	25	(	(	PUNCT
biomedich-684	35	26	fernandez	fernandez	PROPN
biomedich-684	35	27	&	&	CCONJ
biomedich-684	35	28	edel	edel	PROPN
biomedich-684	35	29	,	,	PUNCT
biomedich-684	35	30	2017	2017	NUM
biomedich-684	35	31	)	)	PUNCT
biomedich-684	35	32	.	.	PUNCT
biomedich-684	36	1	therefore	therefore	ADV
biomedich-684	36	2	,	,	PUNCT
biomedich-684	36	3	a	a	DET
biomedich-684	36	4	molecular	molecular	ADJ
biomedich-684	36	5	docking	docking	NOUN
biomedich-684	36	6	approach	approach	NOUN
biomedich-684	36	7	can	can	AUX
biomedich-684	36	8	be	be	AUX
biomedich-684	36	9	carried	carry	VERB
biomedich-684	36	10	out	out	ADP
biomedich-684	36	11	and	and	CCONJ
biomedich-684	36	12	continued	continue	VERB
biomedich-684	36	13	with	with	ADP
biomedich-684	36	14	the	the	DET
biomedich-684	36	15	prediction	prediction	NOUN
biomedich-684	36	16	of	of	ADP
biomedich-684	36	17	its	its	PRON
biomedich-684	36	18	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	36	19	profile	profile	NOUN
biomedich-684	36	20	(	(	PUNCT
biomedich-684	36	21	admet	admet	PROPN
biomedich-684	36	22	)	)	PUNCT
biomedich-684	36	23	.	.	PUNCT
biomedich-684	37	1	the	the	DET
biomedich-684	37	2	docking	docking	NOUN
biomedich-684	37	3	process	process	NOUN
biomedich-684	37	4	begins	begin	VERB
biomedich-684	37	5	by	by	ADP
biomedich-684	37	6	using	use	VERB
biomedich-684	37	7	bioactive	bioactive	ADJ
biomedich-684	37	8	compounds	compound	NOUN
biomedich-684	37	9	of	of	ADP
biomedich-684	37	10	a	a	DET
biomedich-684	37	11	plant	plant	NOUN
biomedich-684	37	12	with	with	ADP
biomedich-684	37	13	a	a	DET
biomedich-684	37	14	protein	protein	NOUN
biomedich-684	37	15	receptor	receptor	NOUN
biomedich-684	37	16	obtained	obtain	VERB
biomedich-684	37	17	from	from	ADP
biomedich-684	37	18	the	the	DET
biomedich-684	37	19	protein	protein	NOUN
biomedich-684	37	20	data	data	PROPN
biomedich-684	37	21	bank	bank	PROPN
biomedich-684	37	22	(	(	PUNCT
biomedich-684	37	23	pdb	pdb	PROPN
biomedich-684	37	24	)	)	PUNCT
biomedich-684	37	25	.	.	PUNCT
biomedich-684	38	1	the	the	DET
biomedich-684	38	2	stem	stem	NOUN
biomedich-684	38	3	bark	bark	NOUN
biomedich-684	38	4	of	of	ADP
biomedich-684	38	5	s.	s.	PROPN
biomedich-684	38	6	quadrifida	quadrifida	PROPN
biomedich-684	38	7	r.	r.	PROPN
biomedich-684	38	8	br	br	PROPN
biomedich-684	38	9	has	have	VERB
biomedich-684	38	10	several	several	ADJ
biomedich-684	38	11	chemical	chemical	ADJ
biomedich-684	38	12	contents	content	NOUN
biomedich-684	38	13	including	include	VERB
biomedich-684	38	14	flavonoids	flavonoid	NOUN
biomedich-684	38	15	,	,	PUNCT
biomedich-684	38	16	tannins	tannin	NOUN
biomedich-684	38	17	,	,	PUNCT
biomedich-684	38	18	alkaloids	alkaloid	NOUN
biomedich-684	38	19	,	,	PUNCT
biomedich-684	38	20	steroids	steroid	NOUN
biomedich-684	38	21	,	,	PUNCT
biomedich-684	38	22	and	and	CCONJ
biomedich-684	38	23	triterpenoids	triterpenoids	PROPN
biomedich-684	38	24	(	(	PUNCT
biomedich-684	38	25	octaviany	octaviany	PROPN
biomedich-684	38	26	&	&	CCONJ
biomedich-684	38	27	iskandar	iskandar	PROPN
biomedich-684	38	28	,	,	PUNCT
biomedich-684	38	29	2023	2023	NUM
biomedich-684	38	30	)	)	PUNCT
biomedich-684	38	31	.	.	PUNCT
biomedich-684	39	1	in	in	ADP
biomedich-684	39	2	addition	addition	NOUN
biomedich-684	39	3	,	,	PUNCT
biomedich-684	39	4	specific	specific	ADJ
biomedich-684	39	5	compounds	compound	NOUN
biomedich-684	39	6	such	such	ADJ
biomedich-684	39	7	as	as	ADP
biomedich-684	39	8	β	β	NOUN
biomedich-684	39	9	-	-	NOUN
biomedich-684	39	10	sitosterol	sitosterol	NOUN
biomedich-684	39	11	,	,	PUNCT
biomedich-684	39	12	catechin	catechin	NOUN
biomedich-684	39	13	,	,	PUNCT
biomedich-684	39	14	epicatechin	epicatechin	NOUN
biomedich-684	39	15	and	and	CCONJ
biomedich-684	39	16	scopoletin	scopoletin	NOUN
biomedich-684	39	17	have	have	AUX
biomedich-684	39	18	been	be	AUX
biomedich-684	39	19	identified	identify	VERB
biomedich-684	39	20	in	in	ADP
biomedich-684	39	21	the	the	DET
biomedich-684	39	22	stem	stem	NOUN
biomedich-684	39	23	bark	bark	NOUN
biomedich-684	39	24	of	of	ADP
biomedich-684	39	25	the	the	DET
biomedich-684	39	26	faloak	faloak	NOUN
biomedich-684	39	27	(	(	PUNCT
biomedich-684	39	28	riwu	riwu	PROPN
biomedich-684	39	29	et	et	PROPN
biomedich-684	39	30	al	al	PROPN
biomedich-684	39	31	.	.	PROPN
biomedich-684	39	32	,	,	PUNCT
biomedich-684	39	33	2024	2024	NUM
biomedich-684	39	34	)	)	PUNCT
biomedich-684	39	35	.	.	PUNCT
biomedich-684	40	1	these	these	DET
biomedich-684	40	2	specific	specific	ADJ
biomedich-684	40	3	biocompounds	biocompound	NOUN
biomedich-684	40	4	will	will	AUX
biomedich-684	40	5	be	be	AUX
biomedich-684	40	6	used	use	VERB
biomedich-684	40	7	in	in	ADP
biomedich-684	40	8	the	the	DET
biomedich-684	40	9	docking	docking	NOUN
biomedich-684	40	10	process	process	NOUN
biomedich-684	40	11	with	with	ADP
biomedich-684	40	12	protein	protein	NOUN
biomedich-684	40	13	receptors	receptor	NOUN
biomedich-684	40	14	obtained	obtain	VERB
biomedich-684	40	15	from	from	ADP
biomedich-684	40	16	protein	protein	NOUN
biomedich-684	40	17	data	datum	NOUN
biomedich-684	40	18	bank	bank	NOUN
biomedich-684	40	19	with	with	ADP
biomedich-684	40	20	mechanisms	mechanism	NOUN
biomedich-684	40	21	as	as	ADP
biomedich-684	40	22	inhibitors	inhibitor	NOUN
biomedich-684	40	23	of	of	ADP
biomedich-684	40	24	α	α	NOUN
biomedich-684	40	25	-	-	PUNCT
biomedich-684	40	26	glucosidase	glucosidase	ADJ
biomedich-684	40	27	,	,	PUNCT
biomedich-684	40	28	ppar	ppar	NOUN
biomedich-684	40	29	-	-	PUNCT
biomedich-684	40	30	γ	γ	NOUN
biomedich-684	40	31	,	,	PUNCT
biomedich-684	40	32	sglt2	sglt2	NOUN
biomedich-684	40	33	,	,	PUNCT
biomedich-684	40	34	dpp	dpp	NOUN
biomedich-684	40	35	-	-	PUNCT
biomedich-684	40	36	iv	iv	NOUN
biomedich-684	40	37	.	.	PUNCT
biomedich-684	41	1	this	this	DET
biomedich-684	41	2	study	study	NOUN
biomedich-684	41	3	aims	aim	VERB
biomedich-684	41	4	to	to	PART
biomedich-684	41	5	strengthen	strengthen	VERB
biomedich-684	41	6	the	the	DET
biomedich-684	41	7	understanding	understanding	NOUN
biomedich-684	41	8	of	of	ADP
biomedich-684	41	9	the	the	DET
biomedich-684	41	10	mechanism	mechanism	NOUN
biomedich-684	41	11	of	of	ADP
biomedich-684	41	12	action	action	NOUN
biomedich-684	41	13	of	of	ADP
biomedich-684	41	14	bioactive	bioactive	ADJ
biomedich-684	41	15	compounds	compound	NOUN
biomedich-684	41	16	in	in	ADP
biomedich-684	41	17	the	the	DET
biomedich-684	41	18	stem	stem	NOUN
biomedich-684	41	19	bark	bark	NOUN
biomedich-684	41	20	of	of	ADP
biomedich-684	41	21	the	the	DET
biomedich-684	41	22	faloak	faloak	NOUN
biomedich-684	41	23	plant	plant	NOUN
biomedich-684	41	24	as	as	ADP
biomedich-684	41	25	inhibitors	inhibitor	NOUN
biomedich-684	41	26	of	of	ADP
biomedich-684	41	27	important	important	ADJ
biomedich-684	41	28	enzymes	enzyme	NOUN
biomedich-684	41	29	associated	associate	VERB
biomedich-684	41	30	with	with	ADP
biomedich-684	41	31	diabetes	diabetes	NOUN
biomedich-684	41	32	,	,	PUNCT
biomedich-684	41	33	such	such	ADJ
biomedich-684	41	34	as	as	ADP
biomedich-684	41	35	α	α	NOUN
biomedich-684	41	36	-	-	PUNCT
biomedich-684	41	37	glucosidase	glucosidase	ADJ
biomedich-684	41	38	,	,	PUNCT
biomedich-684	41	39	ppar	ppar	NOUN
biomedich-684	41	40	-	-	PUNCT
biomedich-684	41	41	γ	γ	NOUN
biomedich-684	41	42	,	,	PUNCT
biomedich-684	41	43	dpp	dpp	NOUN
biomedich-684	41	44	-	-	PUNCT
biomedich-684	41	45	iv	iv	NOUN
biomedich-684	41	46	,	,	PUNCT
biomedich-684	41	47	and	and	CCONJ
biomedich-684	41	48	sglt2	sglt2	X
biomedich-684	41	49	.	.	PUNCT
biomedich-684	42	1	the	the	DET
biomedich-684	42	2	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	42	3	profile	profile	NOUN
biomedich-684	42	4	of	of	ADP
biomedich-684	42	5	the	the	DET
biomedich-684	42	6	bioactive	bioactive	ADJ
biomedich-684	42	7	compounds	compound	NOUN
biomedich-684	42	8	in	in	ADP
biomedich-684	42	9	the	the	DET
biomedich-684	42	10	stem	stem	NOUN
biomedich-684	42	11	bark	bark	NOUN
biomedich-684	42	12	of	of	ADP
biomedich-684	42	13	s.	s.	PROPN
biomedich-684	42	14	quadrifida	quadrifida	PROPN
biomedich-684	42	15	r.	r.	PROPN
biomedich-684	42	16	br	br	PROPN
biomedich-684	42	17	was	be	AUX
biomedich-684	42	18	also	also	ADV
biomedich-684	42	19	obtained	obtain	VERB
biomedich-684	42	20	,	,	PUNCT
biomedich-684	42	21	which	which	PRON
biomedich-684	42	22	can	can	AUX
biomedich-684	42	23	support	support	VERB
biomedich-684	42	24	the	the	DET
biomedich-684	42	25	potential	potential	NOUN
biomedich-684	42	26	of	of	ADP
biomedich-684	42	27	faloak	faloak	NOUN
biomedich-684	42	28	as	as	ADP
biomedich-684	42	29	a	a	DET
biomedich-684	42	30	source	source	NOUN
biomedich-684	42	31	of	of	ADP
biomedich-684	42	32	natural	natural	ADJ
biomedich-684	42	33	materials	material	NOUN
biomedich-684	42	34	in	in	ADP
biomedich-684	42	35	the	the	DET
biomedich-684	42	36	development	development	NOUN
biomedich-684	42	37	of	of	ADP
biomedich-684	42	38	new	new	ADJ
biomedich-684	42	39	antidiabetic	antidiabetic	ADJ
biomedich-684	42	40	drugs	drug	NOUN
biomedich-684	42	41	that	that	PRON
biomedich-684	42	42	are	be	AUX
biomedich-684	42	43	safer	safe	ADJ
biomedich-684	42	44	and	and	CCONJ
biomedich-684	42	45	more	more	ADV
biomedich-684	42	46	effective	effective	ADJ
biomedich-684	42	47	,	,	PUNCT
biomedich-684	42	48	and	and	CCONJ
biomedich-684	42	49	is	be	AUX
biomedich-684	42	50	expected	expect	VERB
biomedich-684	42	51	to	to	PART
biomedich-684	42	52	be	be	AUX
biomedich-684	42	53	the	the	DET
biomedich-684	42	54	basis	basis	NOUN
biomedich-684	42	55	for	for	ADP
biomedich-684	42	56	the	the	DET
biomedich-684	42	57	development	development	NOUN
biomedich-684	42	58	of	of	ADP
biomedich-684	42	59	plant	plant	NOUN
biomedich-684	42	60	-	-	PUNCT
biomedich-684	42	61	based	base	VERB
biomedich-684	42	62	therapies	therapy	NOUN
biomedich-684	42	63	in	in	ADP
biomedich-684	42	64	the	the	DET
biomedich-684	42	65	future	future	NOUN
biomedich-684	42	66	.	.	PUNCT
biomedich-684	43	1	materials	material	NOUN
biomedich-684	43	2	and	and	CCONJ
biomedich-684	43	3	methods	method	NOUN
biomedich-684	43	4	data	datum	NOUN
biomedich-684	43	5	collection	collection	NOUN
biomedich-684	43	6	and	and	CCONJ
biomedich-684	43	7	ligand	ligand	ADJ
biomedich-684	43	8	preparation	preparation	NOUN
biomedich-684	43	9	a	a	DET
biomedich-684	43	10	comprehensive	comprehensive	ADJ
biomedich-684	43	11	review	review	NOUN
biomedich-684	43	12	of	of	ADP
biomedich-684	43	13	the	the	DET
biomedich-684	43	14	existing	exist	VERB
biomedich-684	43	15	literature	literature	NOUN
biomedich-684	43	16	was	be	AUX
biomedich-684	43	17	conducted	conduct	VERB
biomedich-684	43	18	to	to	PART
biomedich-684	43	19	identify	identify	VERB
biomedich-684	43	20	bioactive	bioactive	ADJ
biomedich-684	43	21	compounds	compound	NOUN
biomedich-684	43	22	of	of	ADP
biomedich-684	43	23	potential	potential	ADJ
biomedich-684	43	24	interest	interest	NOUN
biomedich-684	43	25	from	from	ADP
biomedich-684	43	26	the	the	DET
biomedich-684	43	27	stem	stem	NOUN
biomedich-684	43	28	bark	bark	NOUN
biomedich-684	43	29	of	of	ADP
biomedich-684	43	30	the	the	DET
biomedich-684	43	31	faloak	faloak	NOUN
biomedich-684	43	32	plant	plant	NOUN
biomedich-684	43	33	.	.	PUNCT
biomedich-684	44	1	shown	show	VERB
biomedich-684	44	2	in	in	ADP
biomedich-684	44	3	table	table	NOUN
biomedich-684	44	4	01	01	NUM
biomedich-684	44	5	,	,	PUNCT
biomedich-684	44	6	the	the	DET
biomedich-684	44	7	identified	identify	VERB
biomedich-684	44	8	compounds	compound	NOUN
biomedich-684	44	9	included	include	VERB
biomedich-684	44	10	β	β	NOUN
biomedich-684	44	11	-	-	NOUN
biomedich-684	44	12	sitosterol	sitosterol	NOUN
biomedich-684	44	13	,	,	PUNCT
biomedich-684	44	14	catechins	catechin	NOUN
biomedich-684	44	15	,	,	PUNCT
biomedich-684	44	16	epicatechins	epicatechin	NOUN
biomedich-684	44	17	and	and	CCONJ
biomedich-684	44	18	scopoletin	scopoletin	PROPN
biomedich-684	44	19	.	.	PUNCT
biomedich-684	45	1	bioactive	bioactive	PROPN
biomedich-684	45	2	compounds	compound	NOUN
biomedich-684	45	3	and	and	CCONJ
biomedich-684	45	4	ligands	ligand	NOUN
biomedich-684	45	5	were	be	AUX
biomedich-684	45	6	prepared	prepare	VERB
biomedich-684	45	7	using	use	VERB
biomedich-684	45	8	the	the	DET
biomedich-684	45	9	chemdraw	chemdraw	NOUN
biomedich-684	45	10	2d	2d	NUM
biomedich-684	45	11	application	application	NOUN
biomedich-684	45	12	,	,	PUNCT
biomedich-684	45	13	with	with	ADP
biomedich-684	45	14	the	the	DET
biomedich-684	45	15	resultant	resultant	NOUN
biomedich-684	45	16	files	file	NOUN
biomedich-684	45	17	being	be	AUX
biomedich-684	45	18	saved	save	VERB
biomedich-684	45	19	in	in	ADP
biomedich-684	45	20	the	the	DET
biomedich-684	45	21	(	(	PUNCT
biomedich-684	45	22	.cdx	.cdx	NOUN
biomedich-684	45	23	)	)	PUNCT
biomedich-684	45	24	format	format	NOUN
biomedich-684	45	25	.	.	PUNCT
biomedich-684	46	1	energy	energy	NOUN
biomedich-684	46	2	optimization	optimization	NOUN
biomedich-684	46	3	was	be	AUX
biomedich-684	46	4	carried	carry	VERB
biomedich-684	46	5	out	out	ADP
biomedich-684	46	6	with	with	ADP
biomedich-684	46	7	chemdraw	chemdraw	NOUN
biomedich-684	46	8	3d	3d	NUM
biomedich-684	46	9	,	,	PUNCT
biomedich-684	46	10	by	by	ADP
biomedich-684	46	11	selecting	select	VERB
biomedich-684	46	12	minimize	minimize	VERB
biomedich-684	46	13	energy	energy	NOUN
biomedich-684	46	14	mm94	mm94	PROPN
biomedich-684	46	15	and	and	CCONJ
biomedich-684	46	16	saved	save	VERB
biomedich-684	46	17	in	in	ADP
biomedich-684	46	18	(	(	PUNCT
biomedich-684	46	19	.mol2	.mol2	NUM
biomedich-684	46	20	)	)	PUNCT
biomedich-684	46	21	format	format	NOUN
biomedich-684	46	22	.	.	PUNCT
biomedich-684	47	1	protein	protein	NOUN
biomedich-684	47	2	preparations	preparation	NOUN
biomedich-684	47	3	protein	protein	NOUN
biomedich-684	47	4	complex	complex	ADJ
biomedich-684	47	5	structures	structure	NOUN
biomedich-684	47	6	in	in	ADP
biomedich-684	47	7	the	the	DET
biomedich-684	47	8	(	(	PUNCT
biomedich-684	47	9	.pdb	.pdb	ADJ
biomedich-684	47	10	)	)	PUNCT
biomedich-684	47	11	format	format	NOUN
biomedich-684	47	12	were	be	AUX
biomedich-684	47	13	obtained	obtain	VERB
biomedich-684	47	14	from	from	ADP
biomedich-684	47	15	the	the	DET
biomedich-684	47	16	protein	protein	NOUN
biomedich-684	47	17	data	datum	NOUN
biomedich-684	47	18	bank	bank	NOUN
biomedich-684	47	19	,	,	PUNCT
biomedich-684	47	20	which	which	PRON
biomedich-684	47	21	was	be	AUX
biomedich-684	47	22	downloaded	download	VERB
biomedich-684	47	23	from	from	ADP
biomedich-684	47	24	the	the	DET
biomedich-684	47	25	website	website	NOUN
biomedich-684	47	26	http://www.rscb.org/	http://www.rscb.org/	X
biomedich-684	47	27	.	.	PUNCT
biomedich-684	48	1	the	the	DET
biomedich-684	48	2	files	file	NOUN
biomedich-684	48	3	were	be	AUX
biomedich-684	48	4	prepared	prepare	VERB
biomedich-684	48	5	using	use	VERB
biomedich-684	48	6	the	the	DET
biomedich-684	48	7	molegro	molegro	ADJ
biomedich-684	48	8	virtual	virtual	ADJ
biomedich-684	48	9	docker	docker	PROPN
biomedich-684	48	10	application	application	NOUN
biomedich-684	48	11	,	,	PUNCT
biomedich-684	48	12	and	and	CCONJ
biomedich-684	48	13	subsequently	subsequently	ADV
biomedich-684	48	14	saved	save	VERB
biomedich-684	48	15	in	in	ADP
biomedich-684	48	16	the	the	DET
biomedich-684	48	17	(	(	PUNCT
biomedich-684	48	18	.mol2	.mol2	NUM
biomedich-684	48	19	)	)	PUNCT
biomedich-684	48	20	format	format	NOUN
biomedich-684	48	21	.	.	PUNCT
biomedich-684	49	1	protein	protein	NOUN
biomedich-684	49	2	receptors	receptor	NOUN
biomedich-684	49	3	were	be	AUX
biomedich-684	49	4	selected	select	VERB
biomedich-684	49	5	based	base	VERB
biomedich-684	49	6	on	on	ADP
biomedich-684	49	7	their	their	PRON
biomedich-684	49	8	central	central	ADJ
biomedich-684	49	9	role	role	NOUN
biomedich-684	49	10	in	in	ADP
biomedich-684	49	11	diabetes	diabetes	NOUN
biomedich-684	49	12	,	,	PUNCT
biomedich-684	49	13	including	include	VERB
biomedich-684	49	14	as	as	ADP
biomedich-684	49	15	inhibitors	inhibitor	NOUN
biomedich-684	49	16	of	of	ADP
biomedich-684	49	17	αglucosidase	αglucosidase	NOUN
biomedich-684	49	18	(	(	PUNCT
biomedich-684	49	19	3top	3top	NUM
biomedich-684	49	20	)	)	PUNCT
biomedich-684	49	21	,	,	PUNCT
biomedich-684	50	1	ppar	ppar	NOUN
biomedich-684	50	2	-	-	PUNCT
biomedich-684	50	3	γ	γ	X
biomedich-684	50	4	(	(	PUNCT
biomedich-684	50	5	5y20	5y20	NUM
biomedich-684	50	6	)	)	PUNCT
biomedich-684	50	7	,	,	PUNCT
biomedich-684	50	8	sglt2	sglt2	X
biomedich-684	51	1	(	(	PUNCT
biomedich-684	51	2	7vsi	7vsi	NOUN
biomedich-684	51	3	)	)	PUNCT
biomedich-684	51	4	and	and	CCONJ
biomedich-684	51	5	dpp	dpp	PROPN
biomedich-684	51	6	-	-	PUNCT
biomedich-684	51	7	iv	iv	PROPN
biomedich-684	51	8	(	(	PUNCT
biomedich-684	51	9	2rgu	2rgu	NUM
biomedich-684	51	10	)	)	PUNCT
biomedich-684	51	11	(	(	PUNCT
biomedich-684	51	12	table	table	NOUN
biomedich-684	51	13	02	02	NUM
biomedich-684	51	14	)	)	PUNCT
biomedich-684	51	15	.	.	PUNCT
biomedich-684	52	1	internal	internal	ADJ
biomedich-684	52	2	validation	validation	NOUN
biomedich-684	52	3	prepared	prepare	VERB
biomedich-684	52	4	proteins	protein	NOUN
biomedich-684	52	5	were	be	AUX
biomedich-684	52	6	validated	validate	VERB
biomedich-684	52	7	with	with	ADP
biomedich-684	52	8	12	12	NUM
biomedich-684	52	9	combinations	combination	NOUN
biomedich-684	52	10	(	(	PUNCT
biomedich-684	52	11	4	4	NUM
biomedich-684	52	12	scoring	scoring	NOUN
biomedich-684	52	13	functions	function	NOUN
biomedich-684	52	14	and	and	CCONJ
biomedich-684	52	15	3	3	NUM
biomedich-684	52	16	algorithms	algorithm	NOUN
biomedich-684	52	17	)	)	PUNCT
biomedich-684	52	18	until	until	SCONJ
biomedich-684	52	19	rmsd	rmsd	VERB
biomedich-684	52	20	≤	≤	ADJ
biomedich-684	52	21	2å	2å	NOUN
biomedich-684	52	22	was	be	AUX
biomedich-684	52	23	obtained	obtain	VERB
biomedich-684	52	24	.	.	PUNCT
biomedich-684	53	1	this	this	DET
biomedich-684	53	2	validation	validation	NOUN
biomedich-684	53	3	aims	aim	VERB
biomedich-684	53	4	to	to	PART
biomedich-684	53	5	ensure	ensure	VERB
biomedich-684	53	6	that	that	SCONJ
biomedich-684	53	7	the	the	DET
biomedich-684	53	8	docking	docking	NOUN
biomedich-684	53	9	protocol	protocol	NOUN
biomedich-684	53	10	is	be	AUX
biomedich-684	53	11	appropriate	appropriate	ADJ
biomedich-684	53	12	.	.	PUNCT
biomedich-684	54	1	physicochemical	physicochemical	ADJ
biomedich-684	54	2	analysis	analysis	NOUN
biomedich-684	54	3	the	the	DET
biomedich-684	54	4	drug	drug	NOUN
biomedich-684	54	5	-	-	PUNCT
biomedich-684	54	6	likeness	likeness	NOUN
biomedich-684	54	7	of	of	ADP
biomedich-684	54	8	the	the	DET
biomedich-684	54	9	physicochemical	physicochemical	ADJ
biomedich-684	54	10	compounds	compound	NOUN
biomedich-684	54	11	was	be	AUX
biomedich-684	54	12	evaluated	evaluate	VERB
biomedich-684	54	13	using	use	VERB
biomedich-684	54	14	lipinski	lipinski	PROPN
biomedich-684	54	15	’s	’s	PART
biomedich-684	54	16	rule	rule	NOUN
biomedich-684	54	17	of	of	ADP
biomedich-684	54	18	five	five	NUM
biomedich-684	54	19	.	.	PUNCT
biomedich-684	55	1	for	for	SCONJ
biomedich-684	55	2	a	a	DET
biomedich-684	55	3	compound	compound	NOUN
biomedich-684	55	4	to	to	PART
biomedich-684	55	5	persuade	persuade	VERB
biomedich-684	55	6	as	as	ADP
biomedich-684	55	7	a	a	DET
biomedich-684	55	8	drug	drug	NOUN
biomedich-684	55	9	,	,	PUNCT
biomedich-684	55	10	it	it	PRON
biomedich-684	55	11	must	must	AUX
biomedich-684	55	12	satisfy	satisfy	VERB
biomedich-684	55	13	a	a	DET
biomedich-684	55	14	set	set	NOUN
biomedich-684	55	15	of	of	ADP
biomedich-684	55	16	parameters	parameter	NOUN
biomedich-684	55	17	that	that	PRON
biomedich-684	55	18	will	will	AUX
biomedich-684	55	19	prove	prove	VERB
biomedich-684	55	20	its	its	PRON
biomedich-684	55	21	compatibility	compatibility	NOUN
biomedich-684	55	22	,	,	PUNCT
biomedich-684	55	23	efficiency	efficiency	NOUN
biomedich-684	55	24	,	,	PUNCT
biomedich-684	55	25	and	and	CCONJ
biomedich-684	55	26	toxicity	toxicity	NOUN
biomedich-684	55	27	.	.	PUNCT
biomedich-684	56	1	molecular	molecular	ADJ
biomedich-684	56	2	docking	dock	VERB
biomedich-684	56	3	the	the	DET
biomedich-684	56	4	molecular	molecular	ADJ
biomedich-684	56	5	docking	docking	NOUN
biomedich-684	56	6	process	process	NOUN
biomedich-684	56	7	between	between	ADP
biomedich-684	56	8	the	the	DET
biomedich-684	56	9	ligand	ligand	NOUN
biomedich-684	56	10	of	of	ADP
biomedich-684	56	11	the	the	DET
biomedich-684	56	12	comparison	comparison	NOUN
biomedich-684	56	13	compound	compound	NOUN
biomedich-684	56	14	and	and	CCONJ
biomedich-684	56	15	the	the	DET
biomedich-684	56	16	bioactive	bioactive	NOUN
biomedich-684	56	17	compound	compound	NOUN
biomedich-684	56	18	was	be	AUX
biomedich-684	56	19	carried	carry	VERB
biomedich-684	56	20	out	out	ADP
biomedich-684	56	21	using	use	VERB
biomedich-684	56	22	the	the	DET
biomedich-684	56	23	molegro	molegro	ADJ
biomedich-684	56	24	virtual	virtual	ADJ
biomedich-684	56	25	docker	docker	PROPN
biomedich-684	56	26	application	application	NOUN
biomedich-684	56	27	.	.	PUNCT
biomedich-684	57	1	the	the	DET
biomedich-684	57	2	results	result	NOUN
biomedich-684	57	3	obtained	obtain	VERB
biomedich-684	57	4	docking	dock	VERB
biomedich-684	57	5	score	score	NOUN
biomedich-684	57	6	of	of	ADP
biomedich-684	57	7	the	the	DET
biomedich-684	57	8	comparator	comparator	NOUN
biomedich-684	57	9	compound	compound	PROPN
biomedich-684	57	10	ligand	ligand	PROPN
biomedich-684	57	11	which	which	PRON
biomedich-684	57	12	will	will	AUX
biomedich-684	57	13	be	be	AUX
biomedich-684	57	14	compared	compare	VERB
biomedich-684	57	15	with	with	ADP
biomedich-684	57	16	the	the	DET
biomedich-684	57	17	score	score	NOUN
biomedich-684	57	18	of	of	ADP
biomedich-684	57	19	the	the	DET
biomedich-684	57	20	bioactive	bioactive	PROPN
biomedich-684	57	21	compound	compound	NOUN
biomedich-684	57	22	ligand	ligand	NOUN
biomedich-684	57	23	.	.	PUNCT
biomedich-684	58	1	visualization	visualization	NOUN
biomedich-684	58	2	ligand	ligand	NOUN
biomedich-684	58	3	-	-	PUNCT
biomedich-684	58	4	receptor	receptor	NOUN
biomedich-684	58	5	complexes	complex	NOUN
biomedich-684	58	6	of	of	ADP
biomedich-684	58	7	bioactive	bioactive	ADJ
biomedich-684	58	8	compounds	compound	NOUN
biomedich-684	58	9	predicted	predict	VERB
biomedich-684	58	10	to	to	PART
biomedich-684	58	11	have	have	VERB
biomedich-684	58	12	antidiabetic	antidiabetic	ADJ
biomedich-684	58	13	activity	activity	NOUN
biomedich-684	58	14	were	be	AUX
biomedich-684	58	15	generated	generate	VERB
biomedich-684	58	16	using	use	VERB
biomedich-684	58	17	biovia	biovia	PROPN
biomedich-684	58	18	discovery	discovery	PROPN
biomedich-684	58	19	studio	studio	NOUN
biomedich-684	58	20	.	.	PUNCT
biomedich-684	59	1	the	the	DET
biomedich-684	59	2	visualization	visualization	NOUN
biomedich-684	59	3	results	result	NOUN
biomedich-684	59	4	were	be	AUX
biomedich-684	59	5	interpreted	interpret	VERB
biomedich-684	59	6	to	to	PART
biomedich-684	59	7	determine	determine	VERB
biomedich-684	59	8	each	each	DET
biomedich-684	59	9	amino	amino	NOUN
biomedich-684	59	10	acid	acid	NOUN
biomedich-684	59	11	interaction	interaction	NOUN
biomedich-684	59	12	that	that	PRON
biomedich-684	59	13	binds	bind	VERB
biomedich-684	59	14	to	to	ADP
biomedich-684	59	15	the	the	DET
biomedich-684	59	16	protein	protein	NOUN
biomedich-684	59	17	’s	’s	PART
biomedich-684	59	18	active	active	ADJ
biomedich-684	59	19	site	site	NOUN
biomedich-684	59	20	.	.	PUNCT
biomedich-684	60	1	in	in	ADP
biomedich-684	60	2	silico	silico	NOUN
biomedich-684	60	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	60	4	parameter	parameter	NOUN
biomedich-684	60	5	prediction	prediction	NOUN
biomedich-684	60	6	(	(	PUNCT
biomedich-684	60	7	admet	admet	PROPN
biomedich-684	60	8	)	)	PUNCT
biomedich-684	60	9	the	the	DET
biomedich-684	60	10	pharmacokinetics	pharmacokinetic	NOUN
biomedich-684	60	11	/	/	SYM
biomedich-684	60	12	admet	admet	NOUN
biomedich-684	60	13	properties	property	NOUN
biomedich-684	60	14	of	of	ADP
biomedich-684	60	15	these	these	DET
biomedich-684	60	16	compounds	compound	NOUN
biomedich-684	60	17	were	be	AUX
biomedich-684	60	18	investigated	investigate	VERB
biomedich-684	60	19	using	use	VERB
biomedich-684	60	20	pkcsm	pkcsm	NOUN
biomedich-684	60	21	an	an	DET
biomedich-684	60	22	online	online	ADJ
biomedich-684	60	23	web	web	NOUN
biomedich-684	60	24	server	server	NOUN
biomedich-684	60	25	(	(	PUNCT
biomedich-684	60	26	https://biosig.lab.uq.edu.au/pkcsm/prediction	https://biosig.lab.uq.edu.au/pkcsm/prediction	NOUN
biomedich-684	60	27	)	)	PUNCT
biomedich-684	60	28	.	.	PUNCT
biomedich-684	61	1	pkcsm	pkcsm	NOUN
biomedich-684	61	2	provides	provide	VERB
biomedich-684	61	3	a	a	DET
biomedich-684	61	4	platform	platform	NOUN
biomedich-684	61	5	for	for	ADP
biomedich-684	61	6	the	the	DET
biomedich-684	61	7	analysis	analysis	NOUN
biomedich-684	61	8	and	and	CCONJ
biomedich-684	61	9	optimization	optimization	NOUN
biomedich-684	61	10	of	of	ADP
biomedich-684	61	11	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	61	12	and	and	CCONJ
biomedich-684	61	13	toxicity	toxicity	NOUN
biomedich-684	61	14	properties	property	NOUN
biomedich-684	61	15	implemented	implement	VERB
biomedich-684	61	16	in	in	ADP
biomedich-684	61	17	a	a	DET
biomedich-684	61	18	user	user	NOUN
biomedich-684	61	19	-	-	PUNCT
biomedich-684	61	20	friendly	friendly	ADJ
biomedich-684	61	21	manner	manner	NOUN
biomedich-684	61	22	.	.	PUNCT
biomedich-684	62	1	http://www.rscb.org/	http://www.rscb.org/	VERB
biomedich-684	62	2	https://biosig.lab.uq.edu.au/pkcsm/prediction	https://biosig.lab.uq.edu.au/pkcsm/prediction	NOUN
biomedich-684	62	3	utami	utami	NOUN
biomedich-684	62	4	et	et	PROPN
biomedich-684	62	5	al	al	PROPN
biomedich-684	62	6	.	.	PROPN
biomedich-684	63	1	–	–	PUNCT
biomedich-684	63	2	antidiabetic	antidiabetic	ADJ
biomedich-684	63	3	activity	activity	NOUN
biomedich-684	63	4	of	of	ADP
biomedich-684	63	5	faloak	faloak	NOUN
biomedich-684	63	6	stem	stem	NOUN
biomedich-684	63	7	bark	bark	NOUN
biomedich-684	63	8	179	179	NUM
biomedich-684	63	9	results	result	NOUN
biomedich-684	63	10	and	and	CCONJ
biomedich-684	63	11	discussion	discussion	NOUN
biomedich-684	63	12	data	datum	NOUN
biomedich-684	63	13	collection	collection	NOUN
biomedich-684	63	14	and	and	CCONJ
biomedich-684	63	15	ligand	ligand	ADJ
biomedich-684	63	16	preparation	preparation	NOUN
biomedich-684	63	17	table	table	NOUN
biomedich-684	63	18	1	1	NUM
biomedich-684	63	19	.	.	PUNCT
biomedich-684	63	20	ligand	ligand	ADJ
biomedich-684	63	21	preparation	preparation	NOUN
biomedich-684	63	22	results	result	NOUN
biomedich-684	63	23	.	.	PUNCT
biomedich-684	64	1	no	no	DET
biomedich-684	64	2	cid	cid	NOUN
biomedich-684	64	3	name	name	NOUN
biomedich-684	64	4	of	of	ADP
biomedich-684	64	5	compounds	compound	NOUN
biomedich-684	64	6	iupac	iupac	PROPN
biomedich-684	64	7	name	name	NOUN
biomedich-684	64	8	isomeric	isomeric	ADJ
biomedich-684	64	9	smiles	smile	VERB
biomedich-684	64	10	1	1	NUM
biomedich-684	64	11	9064	9064	NUM
biomedich-684	64	12	(	(	PUNCT
biomedich-684	64	13	+	+	ADJ
biomedich-684	64	14	)	)	PUNCT
biomedich-684	64	15	-catechin	-catechin	ADJ
biomedich-684	64	16	(	(	PUNCT
biomedich-684	64	17	2r,3s)-2-(3,4	2r,3s)-2-(3,4	NUM
biomedich-684	64	18	-	-	PUNCT
biomedich-684	64	19	dihydroxyphenyl)-3,4	dihydroxyphenyl)-3,4	NOUN
biomedich-684	64	20	-	-	PUNCT
biomedich-684	64	21	dihydro2h	dihydro2h	NOUN
biomedich-684	64	22	-	-	PUNCT
biomedich-684	64	23	chromene-3,5,7	chromene-3,5,7	NOUN
biomedich-684	64	24	-	-	PUNCT
biomedich-684	64	25	triol	triol	VERB
biomedich-684	64	26	c1[c@@h]([c@h](oc2	c1[c@@h]([c@h](oc2	NOUN
biomedich-684	64	27	=	=	SYM
biomedich-684	64	28	cc(=cc(=c21	cc(=cc(=c21	NOUN
biomedich-684	64	29	)	)	PUNCT
biomedich-684	65	1	o)o)c3	o)o)c3	NOUN
biomedich-684	65	2	=	=	NOUN
biomedich-684	65	3	cc(=c(c	cc(=c(c	NOUN
biomedich-684	65	4	=	=	NOUN
biomedich-684	65	5	c3)o)o)o	c3)o)o)o	NUM
biomedich-684	65	6	2	2	NUM
biomedich-684	65	7	72276	72276	NUM
biomedich-684	65	8	epicatechin	epicatechin	NOUN
biomedich-684	65	9	(	(	PUNCT
biomedich-684	65	10	2r,3r)-2-(3,4	2r,3r)-2-(3,4	ADJ
biomedich-684	65	11	-	-	PUNCT
biomedich-684	65	12	dihydroxyphenyl)-3,4	dihydroxyphenyl)-3,4	ADJ
biomedich-684	65	13	-	-	PUNCT
biomedich-684	65	14	dihydro2h	dihydro2h	NOUN
biomedich-684	65	15	-	-	PUNCT
biomedich-684	65	16	chromene-3,5,7	chromene-3,5,7	NOUN
biomedich-684	65	17	-	-	PUNCT
biomedich-684	65	18	triol	triol	VERB
biomedich-684	65	19	c1[c@h]([c@h](oc2	c1[c@h]([c@h](oc2	NOUN
biomedich-684	65	20	=	=	SYM
biomedich-684	65	21	cc(=cc(=c21)o	cc(=cc(=c21)o	NOUN
biomedich-684	65	22	)	)	PUNCT
biomedich-684	65	23	o)c3	o)c3	PROPN
biomedich-684	65	24	=	=	NOUN
biomedich-684	65	25	cc(=c(c	cc(=c(c	NOUN
biomedich-684	65	26	=	=	NOUN
biomedich-684	65	27	c3)o)o)o	c3)o)o)o	NUM
biomedich-684	65	28	3	3	NUM
biomedich-684	65	29	5280460	5280460	NUM
biomedich-684	65	30	scopoletin	scopoletin	NOUN
biomedich-684	65	31	7	7	NUM
biomedich-684	65	32	-	-	PUNCT
biomedich-684	65	33	hydroxy-6	hydroxy-6	NUM
biomedich-684	65	34	-	-	PUNCT
biomedich-684	65	35	methoxychromen-2	methoxychromen-2	NOUN
biomedich-684	65	36	-	-	PUNCT
biomedich-684	65	37	one	one	NUM
biomedich-684	65	38	coc1	coc1	NOUN
biomedich-684	65	39	=	=	SYM
biomedich-684	65	40	c(c	c(c	NOUN
biomedich-684	65	41	=	=	ADJ
biomedich-684	65	42	c2c(=c1)c	c2c(=c1)c	NOUN
biomedich-684	65	43	=	=	NOUN
biomedich-684	65	44	cc(=o)o2)o	cc(=o)o2)o	ADV
biomedich-684	65	45	4	4	NUM
biomedich-684	65	46	222284	222284	NUM
biomedich-684	65	47	β	β	X
biomedich-684	65	48	-	-	PUNCT
biomedich-684	65	49	sitosterol	sitosterol	NOUN
biomedich-684	65	50	(	(	PUNCT
biomedich-684	65	51	3s,8s,9s,10r,13r,14s,17r)-17-[(2r,5r)-5	3s,8s,9s,10r,13r,14s,17r)-17-[(2r,5r)-5	PROPN
biomedich-684	65	52	-	-	PUNCT
biomedich-684	65	53	ethyl6	ethyl6	NOUN
biomedich-684	65	54	-	-	PUNCT
biomedich-684	65	55	methylheptan-2	methylheptan-2	NOUN
biomedich-684	65	56	-	-	PUNCT
biomedich-684	65	57	yl]-10,13	yl]-10,13	NOUN
biomedich-684	65	58	-	-	PUNCT
biomedich-684	65	59	dimethyl2,3,4,7,8,9,11,12,14,15,16,17	dimethyl2,3,4,7,8,9,11,12,14,15,16,17	NOUN
biomedich-684	65	60	-	-	PUNCT
biomedich-684	65	61	dodecahydro-1hcyclopenta[a]phenanthren-3	dodecahydro-1hcyclopenta[a]phenanthren-3	NOUN
biomedich-684	65	62	-	-	PUNCT
biomedich-684	65	63	ol	ol	NOUN
biomedich-684	65	64	cc[c@h](cc[c@@h](c)[c@h]1cc[c@	cc[c@h](cc[c@@h](c)[c@h]1cc[c@	PROPN
biomedich-684	65	65	@h]2[c@@]1(cc[c@h]3[c@h]2cc	@h]2[c@@]1(cc[c@h]3[c@h]2cc	NOUN
biomedich-684	65	66	=	=	SYM
biomedich-684	65	67	c4	c4	NOUN
biomedich-684	65	68	[	[	PUNCT
biomedich-684	65	69	c@@]3(cc[c@@h](c4)o)c)c)c(c)c	c@@]3(cc[c@@h](c4)o)c)c)c(c)c	NOUN
biomedich-684	65	70	protein	protein	NOUN
biomedich-684	65	71	preparation	preparation	NOUN
biomedich-684	65	72	table	table	NOUN
biomedich-684	65	73	2	2	NUM
biomedich-684	65	74	.	.	X
biomedich-684	65	75	protein	protein	NOUN
biomedich-684	65	76	preparation	preparation	NOUN
biomedich-684	65	77	results	result	NOUN
biomedich-684	65	78	.	.	PUNCT
biomedich-684	66	1	no	no	DET
biomedich-684	66	2	3d	3d	NOUN
biomedich-684	66	3	structure	structure	NOUN
biomedich-684	66	4	of	of	ADP
biomedich-684	66	5	protein	protein	NOUN
biomedich-684	66	6	description	description	NOUN
biomedich-684	66	7	native	native	ADJ
biomedich-684	66	8	ligand	ligand	PROPN
biomedich-684	66	9	1	1	NUM
biomedich-684	66	10	2rgu	2rgu	NUM
biomedich-684	66	11	organism	organism	NOUN
biomedich-684	66	12	:	:	PUNCT
biomedich-684	66	13	homo	homo	NOUN
biomedich-684	66	14	sapiens	sapiens	PART
biomedich-684	66	15	method	method	NOUN
biomedich-684	66	16	:	:	PUNCT
biomedich-684	66	17	x	x	X
biomedich-684	66	18	-	-	PUNCT
biomedich-684	66	19	ray	ray	NOUN
biomedich-684	66	20	diffraction	diffraction	NOUN
biomedich-684	66	21	resolution	resolution	NOUN
biomedich-684	66	22	:	:	PUNCT
biomedich-684	66	23	2.60	2.60	NUM
biomedich-684	66	24	å	å	PROPN
biomedich-684	66	25	mutation	mutation	NOUN
biomedich-684	66	26	:	:	PUNCT
biomedich-684	66	27	no	no	DET
biomedich-684	66	28	356	356	NUM
biomedich-684	66	29	8-[(3r)-3	8-[(3r)-3	NUM
biomedich-684	66	30	-	-	PUNCT
biomedich-684	66	31	aminopiperidin-1	aminopiperidin-1	ADP
biomedich-684	66	32	-	-	PUNCT
biomedich-684	66	33	yl]-7	yl]-7	NOUN
biomedich-684	66	34	-	-	PUNCT
biomedich-684	66	35	but-2	but-2	NUM
biomedich-684	66	36	-	-	PUNCT
biomedich-684	66	37	yn-1	yn-1	NOUN
biomedich-684	66	38	-	-	PUNCT
biomedich-684	66	39	yl-3	yl-3	NOUN
biomedich-684	66	40	-	-	PUNCT
biomedich-684	66	41	methyl-1[(4	methyl-1[(4	NOUN
biomedich-684	66	42	-	-	PUNCT
biomedich-684	66	43	methylquinazolin-2	methylquinazolin-2	NOUN
biomedich-684	66	44	-	-	PUNCT
biomedich-684	66	45	yl)methyl]-3,7	yl)methyl]-3,7	PROPN
biomedich-684	66	46	-	-	PUNCT
biomedich-684	66	47	dihydro-1h	dihydro-1h	NOUN
biomedich-684	66	48	-	-	PUNCT
biomedich-684	66	49	purine2,6	purine2,6	PROPN
biomedich-684	66	50	-	-	PROPN
biomedich-684	66	51	d	d	NOUN
biomedich-684	66	52	ione	ione	NOUN
biomedich-684	66	53	2	2	NUM
biomedich-684	67	1	3top	3top	PRON
biomedich-684	67	2	organism	organism	NOUN
biomedich-684	67	3	:	:	PUNCT
biomedich-684	67	4	homo	homo	NOUN
biomedich-684	67	5	sapiens	sapiens	PART
biomedich-684	67	6	method	method	NOUN
biomedich-684	67	7	:	:	PUNCT
biomedich-684	67	8	x	x	X
biomedich-684	67	9	-	-	PUNCT
biomedich-684	67	10	ray	ray	NOUN
biomedich-684	67	11	diffraction	diffraction	NOUN
biomedich-684	67	12	resolution	resolution	NOUN
biomedich-684	67	13	:	:	PUNCT
biomedich-684	67	14	2.88	2.88	NUM
biomedich-684	67	15	å	å	PROPN
biomedich-684	67	16	mutation	mutation	NOUN
biomedich-684	67	17	:	:	PUNCT
biomedich-684	67	18	no	no	DET
biomedich-684	67	19	alfa	alfa	NOUN
biomedich-684	67	20	-	-	PUNCT
biomedich-684	67	21	acarbose	acarbose	NOUN
biomedich-684	67	22	3	3	NUM
biomedich-684	67	23	5y2o	5y2o	PROPN
biomedich-684	67	24	organism	organism	NOUN
biomedich-684	67	25	:	:	PUNCT
biomedich-684	67	26	homo	homo	NOUN
biomedich-684	67	27	sapiens	sapiens	PART
biomedich-684	67	28	method	method	NOUN
biomedich-684	67	29	:	:	PUNCT
biomedich-684	67	30	x	x	X
biomedich-684	67	31	-	-	PUNCT
biomedich-684	67	32	ray	ray	NOUN
biomedich-684	67	33	diffraction	diffraction	NOUN
biomedich-684	67	34	resolution	resolution	NOUN
biomedich-684	67	35	:	:	PUNCT
biomedich-684	67	36	1.8	1.8	NUM
biomedich-684	67	37	å	å	PROPN
biomedich-684	67	38	mutation	mutation	NOUN
biomedich-684	67	39	:	:	PUNCT
biomedich-684	67	40	no	no	DET
biomedich-684	67	41	(	(	PUNCT
biomedich-684	67	42	5s)-5-[[4-[2-(5	5s)-5-[[4-[2-(5	NUM
biomedich-684	67	43	-	-	PUNCT
biomedich-684	67	44	ethylpyridin-2	ethylpyridin-2	NOUN
biomedich-684	67	45	-	-	NOUN
biomedich-684	67	46	yl)ethoxy]phenyl]methyl]1,3	yl)ethoxy]phenyl]methyl]1,3	VERB
biomedich-684	67	47	-	-	PUNCT
biomedich-684	67	48	thiazolidine-2,4	thiazolidine-2,4	NOUN
biomedich-684	67	49	-	-	PUNCT
biomedich-684	67	50	dione	dione	NOUN
biomedich-684	67	51	4	4	NUM
biomedich-684	67	52	7vsi	7vsi	PROPN
biomedich-684	67	53	organism	organism	NOUN
biomedich-684	67	54	:	:	PUNCT
biomedich-684	67	55	homo	homo	NOUN
biomedich-684	67	56	sapiens	sapiens	PART
biomedich-684	67	57	method	method	NOUN
biomedich-684	67	58	:	:	PUNCT
biomedich-684	68	1	electron	electron	NOUN
biomedich-684	68	2	microscopi	microscopi	NOUN
biomedich-684	68	3	resolution	resolution	NOUN
biomedich-684	68	4	:	:	PUNCT
biomedich-684	68	5	2.95å	2.95å	NUM
biomedich-684	68	6	mutation	mutation	NOUN
biomedich-684	68	7	:	:	PUNCT
biomedich-684	68	8	no	no	PRON
biomedich-684	68	9	7r3	7r3	NUM
biomedich-684	68	10	(	(	PUNCT
biomedich-684	68	11	2s,3r,4r,5s,6r)-2-[4	2s,3r,4r,5s,6r)-2-[4	NUM
biomedich-684	68	12	-	-	PUNCT
biomedich-684	68	13	chloranyl-3-[[4-[(3s)-oxolan-3yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane3,4,5	chloranyl-3-[[4-[(3s)-oxolan-3yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane3,4,5	NOUN
biomedich-684	68	14	-	-	PUNCT
biomedich-684	68	15	triol	triol	NOUN
biomedich-684	68	16	https://pubchem.ncbi.nlm.nih.gov/compound/9064	https://pubchem.ncbi.nlm.nih.gov/compound/9064	PROPN
biomedich-684	68	17	https://pubchem.ncbi.nlm.nih.gov/compound/72276	https://pubchem.ncbi.nlm.nih.gov/compound/72276	PROPN
biomedich-684	68	18	https://pubchem.ncbi.nlm.nih.gov/compound/5280460	https://pubchem.ncbi.nlm.nih.gov/compound/5280460	PROPN
biomedich-684	68	19	https://pubchem.ncbi.nlm.nih.gov/compound/222284	https://pubchem.ncbi.nlm.nih.gov/compound/222284	PROPN
biomedich-684	68	20	180	180	NUM
biomedich-684	68	21	biology	biology	NOUN
biomedich-684	68	22	,	,	PUNCT
biomedich-684	68	23	medicine	medicine	NOUN
biomedich-684	68	24	,	,	PUNCT
biomedich-684	68	25	&	&	CCONJ
biomedich-684	68	26	natural	natural	ADJ
biomedich-684	68	27	product	product	NOUN
biomedich-684	68	28	chemistry	chemistry	NOUN
biomedich-684	68	29	14	14	NUM
biomedich-684	68	30	(	(	PUNCT
biomedich-684	68	31	1	1	NUM
biomedich-684	68	32	)	)	PUNCT
biomedich-684	68	33	,	,	PUNCT
biomedich-684	68	34	2025	2025	NUM
biomedich-684	68	35	:	:	PUNCT
biomedich-684	68	36	177	177	NUM
biomedich-684	68	37	-	-	SYM
biomedich-684	68	38	184	184	NUM
biomedich-684	68	39	internal	internal	ADJ
biomedich-684	68	40	validation	validation	NOUN
biomedich-684	68	41	3top	3top	ADP
biomedich-684	68	42	(	(	PUNCT
biomedich-684	68	43	1,0647	1,0647	NUM
biomedich-684	68	44	å	å	NOUN
biomedich-684	68	45	)	)	PUNCT
biomedich-684	68	46	2rgu	2rgu	PROPN
biomedich-684	68	47	(	(	PUNCT
biomedich-684	68	48	0,537976	0,537976	NOUN
biomedich-684	68	49	å	å	NOUN
biomedich-684	68	50	)	)	PUNCT
biomedich-684	68	51	5y2o	5y2o	PROPN
biomedich-684	68	52	(	(	PUNCT
biomedich-684	68	53	0,67436	0,67436	PROPN
biomedich-684	68	54	å	å	PROPN
biomedich-684	68	55	)	)	PUNCT
biomedich-684	68	56	7vsi	7vsi	NOUN
biomedich-684	68	57	(	(	PUNCT
biomedich-684	68	58	0,573135	0,573135	PROPN
biomedich-684	68	59	å	å	NOUN
biomedich-684	68	60	)	)	PUNCT
biomedich-684	68	61	figure	figure	NOUN
biomedich-684	68	62	1	1	NUM
biomedich-684	68	63	.	.	PUNCT
biomedich-684	69	1	position	position	NOUN
biomedich-684	69	2	of	of	ADP
biomedich-684	69	3	the	the	DET
biomedich-684	69	4	native	native	ADJ
biomedich-684	69	5	ligand	ligand	NOUN
biomedich-684	69	6	superimposed	superimpose	VERB
biomedich-684	69	7	on	on	ADP
biomedich-684	69	8	the	the	DET
biomedich-684	69	9	redocked	redocke	VERB
biomedich-684	69	10	native	native	ADJ
biomedich-684	69	11	ligand	ligand	NOUN
biomedich-684	69	12	.	.	PUNCT
biomedich-684	70	1	table	table	NOUN
biomedich-684	70	2	3	3	NUM
biomedich-684	70	3	.	.	PUNCT
biomedich-684	71	1	root	root	NOUN
biomedich-684	71	2	-	-	PUNCT
biomedich-684	71	3	mean	mean	ADJ
biomedich-684	71	4	-	-	PUNCT
biomedich-684	71	5	square	square	NOUN
biomedich-684	71	6	deviation	deviation	NOUN
biomedich-684	71	7	of	of	ADP
biomedich-684	71	8	protein	protein	NOUN
biomedich-684	71	9	data	datum	NOUN
biomedich-684	71	10	bank	bank	PROPN
biomedich-684	71	11	of	of	ADP
biomedich-684	71	12	a.	a.	NOUN
biomedich-684	71	13	3top	3top	PROPN
biomedich-684	71	14	(	(	PUNCT
biomedich-684	71	15	α	α	NOUN
biomedich-684	71	16	-	-	PUNCT
biomedich-684	71	17	glucosidase	glucosidase	ADJ
biomedich-684	71	18	)	)	PUNCT
biomedich-684	71	19	b.	b.	PROPN
biomedich-684	71	20	2rgu	2rgu	PROPN
biomedich-684	71	21	(	(	PUNCT
biomedich-684	71	22	ppar	ppar	NOUN
biomedich-684	71	23	-	-	PUNCT
biomedich-684	71	24	γ	γ	NOUN
biomedich-684	71	25	)	)	PUNCT
biomedich-684	71	26	c.	c.	PROPN
biomedich-684	71	27	5y2o	5y2o	PROPN
biomedich-684	71	28	(	(	PUNCT
biomedich-684	71	29	sglt2	sglt2	X
biomedich-684	71	30	)	)	PUNCT
biomedich-684	71	31	and	and	CCONJ
biomedich-684	71	32	d.	d.	PROPN
biomedich-684	71	33	7vsi	7vsi	PROPN
biomedich-684	71	34	(	(	PUNCT
biomedich-684	71	35	dpp	dpp	NOUN
biomedich-684	71	36	-	-	PUNCT
biomedich-684	71	37	iv	iv	NOUN
biomedich-684	71	38	)	)	PUNCT
biomedich-684	71	39	.	.	PUNCT
biomedich-684	72	1	a.	a.	NOUN
biomedich-684	72	2	algorithm	algorithm	PROPN
biomedich-684	72	3	moldock	moldock	NOUN
biomedich-684	72	4	optimizer	optimizer	NOUN
biomedich-684	72	5	(	(	PUNCT
biomedich-684	72	6	å	å	NOUN
biomedich-684	72	7	)	)	PUNCT
biomedich-684	72	8	moldock	moldock	NOUN
biomedich-684	72	9	se	se	X
biomedich-684	72	10	(	(	PUNCT
biomedich-684	72	11	å	å	PROPN
biomedich-684	72	12	)	)	PUNCT
biomedich-684	72	13	iterated	iterated	ADJ
biomedich-684	72	14	simplex	simplex	NOUN
biomedich-684	72	15	(	(	PUNCT
biomedich-684	72	16	å	å	NOUN
biomedich-684	72	17	)	)	PUNCT
biomedich-684	72	18	scoring	scoring	NOUN
biomedich-684	72	19	function	function	NOUN
biomedich-684	72	20	moldock	moldock	NOUN
biomedich-684	72	21	score	score	NOUN
biomedich-684	72	22	2,52913	2,52913	PROPN
biomedich-684	72	23	3,0255	3,0255	NUM
biomedich-684	72	24	1,2467	1,2467	PROPN
biomedich-684	72	25	moldock	moldock	NOUN
biomedich-684	72	26	(	(	PUNCT
biomedich-684	72	27	grid	grid	NOUN
biomedich-684	72	28	)	)	PUNCT
biomedich-684	72	29	score	score	NOUN
biomedich-684	72	30	1,0647	1,0647	NUM
biomedich-684	72	31	2,46952	2,46952	NOUN
biomedich-684	72	32	3,74578	3,74578	NUM
biomedich-684	72	33	plants	plant	NOUN
biomedich-684	72	34	score	score	VERB
biomedich-684	72	35	1,42316	1,42316	NUM
biomedich-684	72	36	3,87905	3,87905	NUM
biomedich-684	72	37	2,09881	2,09881	NUM
biomedich-684	72	38	plants	plant	NOUN
biomedich-684	72	39	score	score	NOUN
biomedich-684	72	40	(	(	PUNCT
biomedich-684	72	41	grid	grid	NOUN
biomedich-684	72	42	)	)	PUNCT
biomedich-684	72	43	1,30646	1,30646	PROPN
biomedich-684	72	44	1,48438	1,48438	PROPN
biomedich-684	72	45	2,08955	2,08955	NUM
biomedich-684	72	46	b.	b.	PROPN
biomedich-684	72	47	algorithm	algorithm	PROPN
biomedich-684	72	48	moldock	moldock	NOUN
biomedich-684	72	49	optimizer	optimizer	NOUN
biomedich-684	72	50	(	(	PUNCT
biomedich-684	72	51	å	å	NOUN
biomedich-684	72	52	)	)	PUNCT
biomedich-684	72	53	moldock	moldock	NOUN
biomedich-684	72	54	se	se	X
biomedich-684	72	55	(	(	PUNCT
biomedich-684	72	56	å	å	PROPN
biomedich-684	72	57	)	)	PUNCT
biomedich-684	72	58	iterated	iterated	ADJ
biomedich-684	72	59	simplex	simplex	NOUN
biomedich-684	72	60	(	(	PUNCT
biomedich-684	72	61	å	å	NOUN
biomedich-684	72	62	)	)	PUNCT
biomedich-684	72	63	scoring	scoring	NOUN
biomedich-684	72	64	function	function	NOUN
biomedich-684	72	65	moldock	moldock	NOUN
biomedich-684	72	66	score	score	NOUN
biomedich-684	72	67	0,538373	0,538373	PROPN
biomedich-684	72	68	0,537976	0,537976	NOUN
biomedich-684	72	69	1,57811	1,57811	NUM
biomedich-684	72	70	moldock	moldock	PROPN
biomedich-684	72	71	(	(	PUNCT
biomedich-684	72	72	grid	grid	NOUN
biomedich-684	72	73	)	)	PUNCT
biomedich-684	72	74	score	score	NOUN
biomedich-684	72	75	1,64074	1,64074	PROPN
biomedich-684	72	76	1,56222	1,56222	PROPN
biomedich-684	72	77	8,43536	8,43536	NOUN
biomedich-684	72	78	plants	plant	NOUN
biomedich-684	72	79	score	score	VERB
biomedich-684	72	80	2,03736	2,03736	PROPN
biomedich-684	72	81	1,54417	1,54417	NUM
biomedich-684	72	82	2,56408	2,56408	NUM
biomedich-684	72	83	plants	plant	VERB
biomedich-684	72	84	score	score	NOUN
biomedich-684	72	85	(	(	PUNCT
biomedich-684	72	86	grid	grid	NOUN
biomedich-684	72	87	)	)	PUNCT
biomedich-684	72	88	1,96009	1,96009	PROPN
biomedich-684	72	89	1,37038	1,37038	PROPN
biomedich-684	72	90	1,52665	1,52665	PROPN
biomedich-684	72	91	c.	c.	PROPN
biomedich-684	72	92	algorithm	algorithm	PROPN
biomedich-684	72	93	moldock	moldock	NOUN
biomedich-684	72	94	optimizer	optimizer	NOUN
biomedich-684	72	95	(	(	PUNCT
biomedich-684	72	96	å	å	NOUN
biomedich-684	72	97	)	)	PUNCT
biomedich-684	72	98	moldock	moldock	NOUN
biomedich-684	72	99	se	se	X
biomedich-684	72	100	(	(	PUNCT
biomedich-684	72	101	å	å	PROPN
biomedich-684	72	102	)	)	PUNCT
biomedich-684	72	103	iterated	iterated	ADJ
biomedich-684	72	104	simplex	simplex	NOUN
biomedich-684	72	105	(	(	PUNCT
biomedich-684	72	106	å	å	NOUN
biomedich-684	72	107	)	)	PUNCT
biomedich-684	72	108	scoring	scoring	NOUN
biomedich-684	72	109	function	function	NOUN
biomedich-684	72	110	moldock	moldock	NOUN
biomedich-684	72	111	score	score	NOUN
biomedich-684	72	112	1,22248	1,22248	NUM
biomedich-684	72	113	0,67436	0,67436	PROPN
biomedich-684	72	114	0,975562	0,975562	NUM
biomedich-684	72	115	moldock	moldock	NOUN
biomedich-684	72	116	(	(	PUNCT
biomedich-684	72	117	grid	grid	NOUN
biomedich-684	72	118	)	)	PUNCT
biomedich-684	72	119	score	score	NOUN
biomedich-684	72	120	1,07309	1,07309	PROPN
biomedich-684	72	121	3,3379	3,3379	NUM
biomedich-684	72	122	1,47244	1,47244	NUM
biomedich-684	72	123	plants	plant	NOUN
biomedich-684	72	124	score	score	VERB
biomedich-684	72	125	1,0898	1,0898	NUM
biomedich-684	72	126	0,992484	0,992484	NUM
biomedich-684	72	127	1,05486	1,05486	NUM
biomedich-684	72	128	plants	plant	NOUN
biomedich-684	72	129	score	score	NOUN
biomedich-684	72	130	(	(	PUNCT
biomedich-684	72	131	grid	grid	NOUN
biomedich-684	72	132	)	)	PUNCT
biomedich-684	72	133	1,55609	1,55609	NUM
biomedich-684	73	1	1,6986	1,6986	PROPN
biomedich-684	73	2	1,01191	1,01191	PROPN
biomedich-684	73	3	d.	d.	PROPN
biomedich-684	73	4	algorithm	algorithm	PROPN
biomedich-684	73	5	moldock	moldock	PROPN
biomedich-684	73	6	optimizer	optimizer	NOUN
biomedich-684	73	7	(	(	PUNCT
biomedich-684	73	8	å	å	NOUN
biomedich-684	73	9	)	)	PUNCT
biomedich-684	73	10	moldock	moldock	NOUN
biomedich-684	73	11	se	se	X
biomedich-684	73	12	(	(	PUNCT
biomedich-684	73	13	å	å	PROPN
biomedich-684	73	14	)	)	PUNCT
biomedich-684	73	15	iterated	iterated	ADJ
biomedich-684	73	16	simplex	simplex	NOUN
biomedich-684	73	17	(	(	PUNCT
biomedich-684	73	18	å	å	NOUN
biomedich-684	73	19	)	)	PUNCT
biomedich-684	73	20	scoring	scoring	NOUN
biomedich-684	73	21	function	function	NOUN
biomedich-684	73	22	moldock	moldock	NOUN
biomedich-684	73	23	score	score	NOUN
biomedich-684	73	24	0,799375	0,799375	PROPN
biomedich-684	73	25	1,04281	1,04281	NUM
biomedich-684	73	26	0,966411	0,966411	VERB
biomedich-684	73	27	moldock	moldock	NOUN
biomedich-684	73	28	(	(	PUNCT
biomedich-684	73	29	grid	grid	NOUN
biomedich-684	73	30	)	)	PUNCT
biomedich-684	73	31	score	score	NOUN
biomedich-684	73	32	1,11362	1,11362	NUM
biomedich-684	73	33	1,08267	1,08267	PROPN
biomedich-684	73	34	1,02383	1,02383	PROPN
biomedich-684	73	35	plants	plant	NOUN
biomedich-684	73	36	score	score	NOUN
biomedich-684	73	37	0,86853	0,86853	NOUN
biomedich-684	73	38	0,69421	0,69421	NOUN
biomedich-684	73	39	0,800193	0,800193	X
biomedich-684	74	1	plants	plant	NOUN
biomedich-684	74	2	score	score	NOUN
biomedich-684	74	3	(	(	PUNCT
biomedich-684	74	4	grid	grid	NOUN
biomedich-684	74	5	)	)	PUNCT
biomedich-684	74	6	0,906024	0,906024	NOUN
biomedich-684	75	1	0,573135	0,573135	NOUN
biomedich-684	75	2	0,782356	0,782356	NOUN
biomedich-684	75	3	utami	utami	NOUN
biomedich-684	75	4	et	et	PROPN
biomedich-684	75	5	al	al	PROPN
biomedich-684	75	6	.	.	PROPN
biomedich-684	75	7	–	–	PUNCT
biomedich-684	75	8	antidiabetic	antidiabetic	ADJ
biomedich-684	75	9	activity	activity	NOUN
biomedich-684	75	10	of	of	ADP
biomedich-684	75	11	faloak	faloak	NOUN
biomedich-684	75	12	stem	stem	NOUN
biomedich-684	75	13	bark	bark	NOUN
biomedich-684	75	14	181	181	NUM
biomedich-684	75	15	physicochemcical	physicochemcical	ADJ
biomedich-684	75	16	analysis	analysis	NOUN
biomedich-684	75	17	table	table	NOUN
biomedich-684	75	18	4	4	NUM
biomedich-684	75	19	.	.	PUNCT
biomedich-684	76	1	the	the	DET
biomedich-684	76	2	lipinski	lipinski	PROPN
biomedich-684	76	3	’s	’s	PART
biomedich-684	76	4	rule	rule	NOUN
biomedich-684	76	5	of	of	ADP
biomedich-684	76	6	five	five	NUM
biomedich-684	76	7	analysis	analysis	NOUN
biomedich-684	76	8	results	result	NOUN
biomedich-684	76	9	.	.	PUNCT
biomedich-684	77	1	compound	compound	VERB
biomedich-684	77	2	molecular	molecular	ADJ
biomedich-684	77	3	weight	weight	NOUN
biomedich-684	77	4	(	(	PUNCT
biomedich-684	77	5	g	g	NOUN
biomedich-684	77	6	/	/	SYM
biomedich-684	77	7	mol	mol	NOUN
biomedich-684	77	8	)	)	PUNCT
biomedich-684	78	1	num	num	PROPN
biomedich-684	78	2	.	.	PUNCT
biomedich-684	79	1	h	h	NOUN
biomedich-684	79	2	-	-	PUNCT
biomedich-684	79	3	bond	bond	NOUN
biomedich-684	79	4	acceptors	acceptor	NOUN
biomedich-684	79	5	(	(	PUNCT
biomedich-684	79	6	<	<	X
biomedich-684	79	7	10	10	NUM
biomedich-684	79	8	)	)	PUNCT
biomedich-684	79	9	num	num	ADJ
biomedich-684	79	10	.	.	PUNCT
biomedich-684	80	1	h	h	NOUN
biomedich-684	80	2	-	-	PUNCT
biomedich-684	80	3	bond	bond	NOUN
biomedich-684	80	4	donors	donor	NOUN
biomedich-684	80	5	(	(	PUNCT
biomedich-684	80	6	<	<	X
biomedich-684	80	7	5	5	NUM
biomedich-684	80	8	)	)	PUNCT
biomedich-684	80	9	lipophilicity	lipophilicity	NOUN
biomedich-684	80	10	(	(	PUNCT
biomedich-684	80	11	log	log	VERB
biomedich-684	80	12	p<5	p<5	PROPN
biomedich-684	80	13	)	)	PUNCT
biomedich-684	80	14	no	no	INTJ
biomedich-684	80	15	.	.	PROPN
biomedich-684	80	16	of	of	ADP
biomedich-684	80	17	lipinski	lipinski	PROPN
biomedich-684	80	18	’s	’s	PART
biomedich-684	80	19	violation	violation	NOUN
biomedich-684	80	20	beta	beta	PROPN
biomedich-684	80	21	cytosterol	cytosterol	NOUN
biomedich-684	80	22	414.71	414.71	NUM
biomedich-684	80	23	1	1	NUM
biomedich-684	80	24	1	1	NUM
biomedich-684	80	25	8,024803	8,024803	NUM
biomedich-684	80	26	1	1	NUM
biomedich-684	80	27	catechin	catechin	VERB
biomedich-684	80	28	290.27	290.27	NUM
biomedich-684	80	29	6	6	NUM
biomedich-684	80	30	5	5	NUM
biomedich-684	80	31	1,546099	1,546099	NUM
biomedich-684	80	32	0	0	NUM
biomedich-684	80	33	epicatechin	epicatechin	NOUN
biomedich-684	80	34	290.27	290.27	NUM
biomedich-684	80	35	6	6	NUM
biomedich-684	80	36	5	5	NUM
biomedich-684	80	37	1,546099	1,546099	NUM
biomedich-684	80	38	0	0	NUM
biomedich-684	80	39	scopoletin	scopoletin	NOUN
biomedich-684	80	40	192.17	192.17	NUM
biomedich-684	80	41	4	4	NUM
biomedich-684	80	42	1	1	NUM
biomedich-684	80	43	1,333000	1,333000	NUM
biomedich-684	80	44	0	0	NUM
biomedich-684	80	45	molecular	molecular	ADJ
biomedich-684	80	46	docking	docking	NOUN
biomedich-684	80	47	table	table	NOUN
biomedich-684	80	48	5	5	NUM
biomedich-684	80	49	.	.	X
biomedich-684	80	50	molecular	molecular	ADJ
biomedich-684	80	51	docking	docking	NOUN
biomedich-684	80	52	results	result	NOUN
biomedich-684	80	53	.	.	PUNCT
biomedich-684	81	1	compound	compound	NOUN
biomedich-684	81	2	cid	cid	NOUN
biomedich-684	81	3	docking	docking	NOUN
biomedich-684	81	4	score	score	NOUN
biomedich-684	81	5	7vsi	7vsi	NOUN
biomedich-684	81	6	3top	3top	ADJ
biomedich-684	81	7	5y2o	5y2o	PROPN
biomedich-684	81	8	2rgu	2rgu	NUM
biomedich-684	81	9	beta	beta	NOUN
biomedich-684	81	10	cytosterol	cytosterol	NOUN
biomedich-684	81	11	222284	222284	NUM
biomedich-684	81	12	-119,548	-119,548	PUNCT
biomedich-684	82	1	-107,759	-107,759	ADP
biomedich-684	82	2	-78,7945	-78,7945	PRON
biomedich-684	82	3	-98,8838	-98,8838	PUNCT
biomedich-684	82	4	catechin	catechin	PROPN
biomedich-684	82	5	9064	9064	NUM
biomedich-684	82	6	-94,293	-94,293	PROPN
biomedich-684	82	7	-82,5122	-82,5122	PROPN
biomedich-684	82	8	-82,733	-82,733	PROPN
biomedich-684	82	9	-83,4336	-83,4336	PROPN
biomedich-684	82	10	epicatechin	epicatechin	NOUN
biomedich-684	82	11	72276	72276	NUM
biomedich-684	82	12	-99,5256	-99,5256	X
biomedich-684	82	13	-65,3541	-65,3541	PUNCT
biomedich-684	82	14	-81,9963	-81,9963	PUNCT
biomedich-684	82	15	-83,9022	-83,9022	NOUN
biomedich-684	82	16	scopoletin	scopoletin	NOUN
biomedich-684	82	17	5280460	5280460	NUM
biomedich-684	82	18	-71,3226	-71,3226	PROPN
biomedich-684	82	19	-66,4612	-66,4612	PROPN
biomedich-684	82	20	-65,0435	-65,0435	ADP
biomedich-684	82	21	-58,7893	-58,7893	PUNCT
biomedich-684	82	22	alogliptin	alogliptin	ADJ
biomedich-684	82	23	11450633	11450633	NUM
biomedich-684	82	24	-94,7326	-94,7326	PUNCT
biomedich-684	82	25	linagliptin	linagliptin	ADJ
biomedich-684	82	26	10096344	10096344	NUM
biomedich-684	82	27	-93,8655	-93,8655	NOUN
biomedich-684	82	28	sitagliptin	sitagliptin	NOUN
biomedich-684	82	29	4369359	4369359	NUM
biomedich-684	82	30	-87,8399	-87,8399	PROPN
biomedich-684	82	31	vildagliptin	vildagliptin	PROPN
biomedich-684	82	32	6918537	6918537	NUM
biomedich-684	82	33	-78,2888	-78,2888	PROPN
biomedich-684	82	34	saxagliptin	saxagliptin	NOUN
biomedich-684	82	35	11243969	11243969	NUM
biomedich-684	82	36	-66,9827	-66,9827	NOUN
biomedich-684	82	37	acarbose	acarbose	PROPN
biomedich-684	82	38	41774	41774	NUM
biomedich-684	82	39	-145,932	-145,932	PUNCT
biomedich-684	82	40	troglitazone	troglitazone	NOUN
biomedich-684	82	41	5591	5591	NUM
biomedich-684	82	42	-131,227	-131,227	ADP
biomedich-684	82	43	pioglitazone	pioglitazone	NOUN
biomedich-684	82	44	4829	4829	NUM
biomedich-684	82	45	-114,821	-114,821	PUNCT
biomedich-684	82	46	rosiglitazone	rosiglitazone	NOUN
biomedich-684	82	47	77999	77999	NUM
biomedich-684	82	48	-110,379	-110,379	SYM
biomedich-684	82	49	dapagliflozin	dapagliflozin	PROPN
biomedich-684	82	50	9887712	9887712	NUM
biomedich-684	82	51	-122,592	-122,592	PUNCT
biomedich-684	82	52	canagliflozin	canagliflozin	PROPN
biomedich-684	82	53	24812758	24812758	NUM
biomedich-684	82	54	-136,445	-136,445	NOUN
biomedich-684	82	55	empagliflozin	empagliflozin	VERB
biomedich-684	82	56	11949646	11949646	NUM
biomedich-684	83	1	-135,666	-135,666	SYM
biomedich-684	84	1	3d	3d	NUM
biomedich-684	84	2	2d	2d	NUM
biomedich-684	84	3	figure	figure	NOUN
biomedich-684	84	4	2	2	NUM
biomedich-684	84	5	.	.	PUNCT
biomedich-684	85	1	beta	beta	NOUN
biomedich-684	85	2	cytosterol	cytosterol	NOUN
biomedich-684	85	3	best	well	ADV
biomedich-684	85	4	interacts	interact	VERB
biomedich-684	85	5	with	with	ADP
biomedich-684	85	6	receptors	receptor	NOUN
biomedich-684	85	7	.	.	PUNCT
biomedich-684	86	1	3d	3d	NUM
biomedich-684	86	2	2d	2d	NUM
biomedich-684	86	3	figure	figure	NOUN
biomedich-684	86	4	3	3	NUM
biomedich-684	86	5	.	.	PUNCT
biomedich-684	87	1	catechin	catechin	PROPN
biomedich-684	87	2	best	well	ADV
biomedich-684	87	3	interacts	interact	VERB
biomedich-684	87	4	with	with	ADP
biomedich-684	87	5	receptors	receptor	NOUN
biomedich-684	87	6	.	.	PUNCT
biomedich-684	88	1	3d	3d	NUM
biomedich-684	88	2	2d	2d	NUM
biomedich-684	88	3	figure	figure	NOUN
biomedich-684	88	4	4	4	NUM
biomedich-684	88	5	.	.	PUNCT
biomedich-684	89	1	epicatechin	epicatechin	PROPN
biomedich-684	89	2	best	well	ADV
biomedich-684	89	3	interacts	interact	VERB
biomedich-684	89	4	with	with	ADP
biomedich-684	89	5	receptors	receptor	NOUN
biomedich-684	89	6	.	.	PUNCT
biomedich-684	90	1	https://pubchem.ncbi.nlm.nih.gov/compound/5280460	https://pubchem.ncbi.nlm.nih.gov/compound/5280460	PROPN
biomedich-684	90	2	https://pubchem.ncbi.nlm.nih.gov/compound/11450633	https://pubchem.ncbi.nlm.nih.gov/compound/11450633	PROPN
biomedich-684	90	3	https://pubchem.ncbi.nlm.nih.gov/compound/10096344	https://pubchem.ncbi.nlm.nih.gov/compound/10096344	PROPN
biomedich-684	90	4	https://pubchem.ncbi.nlm.nih.gov/compound/4369359	https://pubchem.ncbi.nlm.nih.gov/compound/4369359	PROPN
biomedich-684	90	5	https://pubchem.ncbi.nlm.nih.gov/compound/11243969	https://pubchem.ncbi.nlm.nih.gov/compound/11243969	PROPN
biomedich-684	90	6	https://pubchem.ncbi.nlm.nih.gov/compound/41774	https://pubchem.ncbi.nlm.nih.gov/compound/41774	PROPN
biomedich-684	90	7	https://pubchem.ncbi.nlm.nih.gov/compound/5591	https://pubchem.ncbi.nlm.nih.gov/compound/5591	PROPN
biomedich-684	90	8	https://pubchem.ncbi.nlm.nih.gov/compound/4829	https://pubchem.ncbi.nlm.nih.gov/compound/4829	PROPN
biomedich-684	90	9	https://pubchem.ncbi.nlm.nih.gov/compound/77999	https://pubchem.ncbi.nlm.nih.gov/compound/77999	PROPN
biomedich-684	90	10	https://pubchem.ncbi.nlm.nih.gov/compound/9887712	https://pubchem.ncbi.nlm.nih.gov/compound/9887712	PROPN
biomedich-684	90	11	https://pubchem.ncbi.nlm.nih.gov/compound/24812758	https://pubchem.ncbi.nlm.nih.gov/compound/24812758	PROPN
biomedich-684	90	12	https://pubchem.ncbi.nlm.nih.gov/compound/11949646	https://pubchem.ncbi.nlm.nih.gov/compound/11949646	PROPN
biomedich-684	90	13	182	182	NUM
biomedich-684	90	14	biology	biology	NOUN
biomedich-684	90	15	,	,	PUNCT
biomedich-684	90	16	medicine	medicine	NOUN
biomedich-684	90	17	,	,	PUNCT
biomedich-684	90	18	&	&	CCONJ
biomedich-684	90	19	natural	natural	ADJ
biomedich-684	90	20	product	product	NOUN
biomedich-684	90	21	chemistry	chemistry	NOUN
biomedich-684	90	22	14	14	NUM
biomedich-684	90	23	(	(	PUNCT
biomedich-684	90	24	1	1	NUM
biomedich-684	90	25	)	)	PUNCT
biomedich-684	90	26	,	,	PUNCT
biomedich-684	90	27	2025	2025	NUM
biomedich-684	90	28	:	:	PUNCT
biomedich-684	90	29	177	177	NUM
biomedich-684	90	30	-	-	SYM
biomedich-684	90	31	184	184	NUM
biomedich-684	90	32	in	in	ADP
biomedich-684	90	33	silico	silico	NOUN
biomedich-684	90	34	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	90	35	parameter	parameter	NOUN
biomedich-684	90	36	prediction	prediction	NOUN
biomedich-684	90	37	(	(	PUNCT
biomedich-684	90	38	admet	admet	ADJ
biomedich-684	90	39	)	)	PUNCT
biomedich-684	90	40	table	table	NOUN
biomedich-684	90	41	6	6	NUM
biomedich-684	90	42	.	.	PUNCT
biomedich-684	91	1	the	the	DET
biomedich-684	91	2	predicted	predict	VERB
biomedich-684	91	3	admet	admet	NOUN
biomedich-684	91	4	properties	property	NOUN
biomedich-684	91	5	of	of	ADP
biomedich-684	91	6	the	the	DET
biomedich-684	91	7	bioactive	bioactive	PROPN
biomedich-684	91	8	compounds	compound	NOUN
biomedich-684	91	9	;	;	PUNCT
biomedich-684	91	10	1	1	NUM
biomedich-684	91	11	-	-	PUNCT
biomedich-684	91	12	water	water	NOUN
biomedich-684	91	13	solubility	solubility	NOUN
biomedich-684	91	14	(	(	PUNCT
biomedich-684	91	15	log	log	PROPN
biomedich-684	91	16	mol	mol	PROPN
biomedich-684	91	17	/	/	SYM
biomedich-684	91	18	l	l	NOUN
biomedich-684	91	19	)	)	PUNCT
biomedich-684	91	20	2	2	NUM
biomedich-684	91	21	-caco2	-caco2	PROPN
biomedich-684	91	22	permeability	permeability	NOUN
biomedich-684	91	23	(	(	PUNCT
biomedich-684	91	24	papp	papp	NOUN
biomedich-684	91	25	)	)	PUNCT
biomedich-684	91	26	3	3	NUM
biomedich-684	91	27	-	-	PUNCT
biomedich-684	91	28	human	human	ADJ
biomedich-684	91	29	intestinal	intestinal	ADJ
biomedich-684	91	30	absorption	absorption	NOUN
biomedich-684	91	31	(	(	PUNCT
biomedich-684	91	32	%	%	NOUN
biomedich-684	91	33	)	)	PUNCT
biomedich-684	91	34	4	4	NUM
biomedich-684	91	35	-	-	PUNCT
biomedich-684	91	36	volume	volume	NOUN
biomedich-684	91	37	of	of	ADP
biomedich-684	91	38	distribution	distribution	NOUN
biomedich-684	91	39	at	at	ADP
biomedich-684	91	40	steady	steady	ADJ
biomedich-684	91	41	-	-	PUNCT
biomedich-684	91	42	state	state	NOUN
biomedich-684	91	43	(	(	PUNCT
biomedich-684	91	44	log	log	NOUN
biomedich-684	91	45	l	l	NOUN
biomedich-684	91	46	/	/	SYM
biomedich-684	91	47	kg	kg	NOUN
biomedich-684	91	48	)	)	PUNCT
biomedich-684	91	49	5	5	NUM
biomedich-684	91	50	-	-	PUNCT
biomedich-684	91	51	fraction	fraction	NOUN
biomedich-684	91	52	unbound	unbound	NOUN
biomedich-684	91	53	(	(	PUNCT
biomedich-684	91	54	fu	fu	NOUN
biomedich-684	91	55	)	)	PUNCT
biomedich-684	91	56	6	6	NUM
biomedich-684	91	57	-	-	PUNCT
biomedich-684	91	58	blood	blood	NOUN
biomedich-684	91	59	brain	brain	NOUN
biomedich-684	91	60	barrier	barrier	NOUN
biomedich-684	91	61	permeability	permeability	NOUN
biomedich-684	91	62	(	(	PUNCT
biomedich-684	91	63	log	log	NOUN
biomedich-684	91	64	bb	bb	NOUN
biomedich-684	91	65	)	)	PUNCT
biomedich-684	91	66	7	7	NUM
biomedich-684	91	67	-	-	PUNCT
biomedich-684	91	68	cytochromes	cytochrome	NOUN
biomedich-684	91	69	p450	p450	PROPN
biomedich-684	91	70	substrates	substrate	VERB
biomedich-684	91	71	8	8	NUM
biomedich-684	91	72	-	-	PUNCT
biomedich-684	91	73	cytochromes	cytochrome	NOUN
biomedich-684	91	74	p450	p450	PROPN
biomedich-684	91	75	inhibitors	inhibitor	NOUN
biomedich-684	91	76	9	9	NUM
biomedich-684	91	77	-	-	PUNCT
biomedich-684	91	78	total	total	NOUN
biomedich-684	91	79	clearance	clearance	NOUN
biomedich-684	91	80	(	(	PUNCT
biomedich-684	91	81	log	log	VERB
biomedich-684	91	82	ml	ml	NOUN
biomedich-684	91	83	/	/	SYM
biomedich-684	91	84	min	min	NOUN
biomedich-684	91	85	/	/	SYM
biomedich-684	91	86	kg	kg	NOUN
biomedich-684	91	87	)	)	PUNCT
biomedich-684	91	88	10	10	NUM
biomedich-684	91	89	-	-	PUNCT
biomedich-684	91	90	renal	renal	ADJ
biomedich-684	91	91	organic	organic	ADJ
biomedich-684	91	92	cation	cation	NOUN
biomedich-684	91	93	transporter	transporter	NOUN
biomedich-684	91	94	2	2	NUM
biomedich-684	91	95	substrate	substrate	NOUN
biomedich-684	91	96	11	11	NUM
biomedich-684	91	97	-	-	PUNCT
biomedich-684	91	98	ames	ame	NOUN
biomedich-684	91	99	toxicity	toxicity	NOUN
biomedich-684	91	100	12max	12max	NOUN
biomedich-684	91	101	tolerated	tolerate	VERB
biomedich-684	91	102	dose	dose	PROPN
biomedich-684	91	103	(	(	PUNCT
biomedich-684	91	104	human	human	NOUN
biomedich-684	91	105	)	)	PUNCT
biomedich-684	91	106	(	(	PUNCT
biomedich-684	91	107	log	log	VERB
biomedich-684	91	108	mg	mg	PROPN
biomedich-684	91	109	/	/	SYM
biomedich-684	91	110	kg	kg	PROPN
biomedich-684	91	111	/	/	SYM
biomedich-684	91	112	day	day	NOUN
biomedich-684	91	113	)	)	PUNCT
biomedich-684	91	114	13	13	NUM
biomedich-684	91	115	-	-	PUNCT
biomedich-684	91	116	lethal	lethal	ADJ
biomedich-684	91	117	dose	dose	NOUN
biomedich-684	91	118	50	50	NUM
biomedich-684	91	119	(	(	PUNCT
biomedich-684	91	120	mol	mol	PROPN
biomedich-684	91	121	/	/	SYM
biomedich-684	91	122	kg	kg	NOUN
biomedich-684	91	123	)	)	PUNCT
biomedich-684	91	124	14	14	NUM
biomedich-684	91	125	-	-	PUNCT
biomedich-684	91	126	hepatotoxicity	hepatotoxicity	NOUN
biomedich-684	91	127	.	.	PUNCT
biomedich-684	92	1	compound	compound	NOUN
biomedich-684	92	2	absorption	absorption	NOUN
biomedich-684	92	3	distribution	distribution	NOUN
biomedich-684	92	4	metabolism	metabolism	NOUN
biomedich-684	92	5	excretion	excretion	NOUN
biomedich-684	92	6	toxicity	toxicity	NOUN
biomedich-684	92	7	ws1	ws1	PROPN
biomedich-684	92	8	cp2	cp2	PROPN
biomedich-684	92	9	hia3	hia3	PROPN
biomedich-684	92	10	vdss4	vdss4	PROPN
biomedich-684	92	11	fu5	fu5	VERB
biomedich-684	92	12	bbb6	bbb6	VERB
biomedich-684	92	13	cyps7	cyps7	PROPN
biomedich-684	92	14	cypi8	cypi8	PROPN
biomedich-684	92	15	tc9	tc9	VERB
biomedich-684	92	16	ros10	ros10	ADJ
biomedich-684	92	17	ames11	ames11	NOUN
biomedich-684	92	18	mtd12	mtd12	PROPN
biomedich-684	92	19	ld13	ld13	PROPN
biomedich-684	92	20	ht14	ht14	PROPN
biomedich-684	92	21	beta	beta	ADJ
biomedich-684	92	22	cytosterol	cytosterol	NOUN
biomedich-684	92	23	-6.773	-6.773	ADP
biomedich-684	92	24	1.201	1.201	NUM
biomedich-684	92	25	94.464	94.464	NUM
biomedich-684	92	26	0.193	0.193	NUM
biomedich-684	92	27	0	0	NUM
biomedich-684	92	28	0.781	0.781	NUM
biomedich-684	92	29	3a4	3a4	NUM
biomedich-684	92	30	0.628	0.628	NUM
biomedich-684	92	31	no	no	INTJ
biomedich-684	92	32	no	no	PRON
biomedich-684	92	33	-0.621	-0.621	NUM
biomedich-684	92	34	2.552	2.552	NUM
biomedich-684	92	35	no	no	DET
biomedich-684	92	36	catechin	catechin	NOUN
biomedich-684	92	37	-3.117	-3.117	PRON
biomedich-684	92	38	-0.283	-0.283	PUNCT
biomedich-684	92	39	68.829	68.829	NUM
biomedich-684	92	40	1.027	1.027	NUM
biomedich-684	92	41	0.236	0.236	NUM
biomedich-684	92	42	-1.054	-1.054	NOUN
biomedich-684	92	43	0.183	0.183	NUM
biomedich-684	92	44	no	no	INTJ
biomedich-684	92	45	no	no	DET
biomedich-684	92	46	0.438	0.438	NUM
biomedich-684	92	47	2.428	2.428	NUM
biomedich-684	92	48	no	no	DET
biomedich-684	92	49	epicatechin	epicatechin	NOUN
biomedich-684	92	50	-3.117	-3.117	PUNCT
biomedich-684	93	1	-0.283	-0.283	PUNCT
biomedich-684	94	1	68.829	68.829	NUM
biomedich-684	94	2	1.027	1.027	NUM
biomedich-684	94	3	0.236	0.236	NUM
biomedich-684	94	4	-1.054	-1.054	NOUN
biomedich-684	94	5	0.183	0.183	NUM
biomedich-684	94	6	no	no	INTJ
biomedich-684	94	7	no	no	DET
biomedich-684	94	8	0.438	0.438	NUM
biomedich-684	94	9	2.428	2.428	NUM
biomedich-684	94	10	no	no	DET
biomedich-684	94	11	scopoletin	scopoletin	NOUN
biomedich-684	94	12	-2.504	-2.504	PUNCT
biomedich-684	94	13	1.184	1.184	NUM
biomedich-684	94	14	95.277	95.277	NUM
biomedich-684	94	15	0.034	0.034	NUM
biomedich-684	94	16	0.383	0.383	NUM
biomedich-684	94	17	-0.299	-0.299	VERB
biomedich-684	94	18	1a2	1a2	NUM
biomedich-684	94	19	0.730	0.730	NUM
biomedich-684	94	20	no	no	INTJ
biomedich-684	94	21	no	no	DET
biomedich-684	94	22	0.614	0.614	NUM
biomedich-684	94	23	1.950	1.950	NUM
biomedich-684	94	24	no	no	DET
biomedich-684	94	25	discussion	discussion	NOUN
biomedich-684	94	26	internal	internal	ADJ
biomedich-684	94	27	validation	validation	NOUN
biomedich-684	94	28	validation	validation	NOUN
biomedich-684	94	29	was	be	AUX
biomedich-684	94	30	performed	perform	VERB
biomedich-684	94	31	by	by	ADP
biomedich-684	94	32	tethering	tether	VERB
biomedich-684	94	33	a	a	DET
biomedich-684	94	34	standard	standard	ADJ
biomedich-684	94	35	ligand	ligand	NOUN
biomedich-684	94	36	as	as	ADP
biomedich-684	94	37	a	a	DET
biomedich-684	94	38	re	re	ADJ
biomedich-684	94	39	-	-	ADJ
biomedich-684	94	40	docking	docking	ADJ
biomedich-684	94	41	protocol	protocol	NOUN
biomedich-684	94	42	with	with	ADP
biomedich-684	94	43	a	a	DET
biomedich-684	94	44	pre	pre	ADJ
biomedich-684	94	45	-	-	ADJ
biomedich-684	94	46	prepared	prepared	ADJ
biomedich-684	94	47	receptor	receptor	NOUN
biomedich-684	94	48	.	.	PUNCT
biomedich-684	95	1	the	the	DET
biomedich-684	95	2	standard	standard	ADJ
biomedich-684	95	3	ligand	ligand	NOUN
biomedich-684	95	4	was	be	AUX
biomedich-684	95	5	utilized	utilize	VERB
biomedich-684	95	6	as	as	ADP
biomedich-684	95	7	a	a	DET
biomedich-684	95	8	tethering	tether	VERB
biomedich-684	95	9	protocol	protocol	NOUN
biomedich-684	95	10	to	to	PART
biomedich-684	95	11	predict	predict	VERB
biomedich-684	95	12	the	the	DET
biomedich-684	95	13	position	position	NOUN
biomedich-684	95	14	and	and	CCONJ
biomedich-684	95	15	ligand	ligand	ADJ
biomedich-684	95	16	-	-	PUNCT
biomedich-684	95	17	protein	protein	NOUN
biomedich-684	95	18	interaction	interaction	NOUN
biomedich-684	95	19	.	.	PUNCT
biomedich-684	96	1	the	the	DET
biomedich-684	96	2	tethering	tethering	NOUN
biomedich-684	96	3	was	be	AUX
biomedich-684	96	4	performed	perform	VERB
biomedich-684	96	5	using	use	VERB
biomedich-684	96	6	molegro	molegro	ADJ
biomedich-684	96	7	virtual	virtual	ADJ
biomedich-684	96	8	docker	docker	PROPN
biomedich-684	96	9	and	and	CCONJ
biomedich-684	96	10	the	the	DET
biomedich-684	96	11	rmsd	rmsd	NOUN
biomedich-684	96	12	(	(	PUNCT
biomedich-684	96	13	root	root	NOUN
biomedich-684	96	14	mean	mean	ADJ
biomedich-684	96	15	square	square	ADJ
biomedich-684	96	16	deviation	deviation	NOUN
biomedich-684	96	17	)	)	PUNCT
biomedich-684	96	18	value	value	NOUN
biomedich-684	96	19	was	be	AUX
biomedich-684	96	20	observed	observe	VERB
biomedich-684	96	21	(	(	PUNCT
biomedich-684	96	22	zubair	zubair	PROPN
biomedich-684	96	23	et	et	PROPN
biomedich-684	96	24	al	al	PROPN
biomedich-684	96	25	.	.	PROPN
biomedich-684	96	26	,	,	PUNCT
biomedich-684	96	27	2020	2020	NUM
biomedich-684	96	28	)	)	PUNCT
biomedich-684	96	29	.	.	PUNCT
biomedich-684	97	1	the	the	DET
biomedich-684	97	2	root	root	NOUN
biomedich-684	97	3	-	-	PUNCT
biomedich-684	97	4	mean	mean	ADJ
biomedich-684	97	5	-	-	PUNCT
biomedich-684	97	6	square	square	NOUN
biomedich-684	97	7	deviation	deviation	NOUN
biomedich-684	97	8	value	value	NOUN
biomedich-684	97	9	is	be	AUX
biomedich-684	97	10	utilized	utilize	VERB
biomedich-684	97	11	to	to	PART
biomedich-684	97	12	evaluate	evaluate	VERB
biomedich-684	97	13	the	the	DET
biomedich-684	97	14	similarity	similarity	NOUN
biomedich-684	97	15	of	of	ADP
biomedich-684	97	16	coordinates	coordinate	NOUN
biomedich-684	97	17	between	between	ADP
biomedich-684	97	18	two	two	NUM
biomedich-684	97	19	atoms	atom	NOUN
biomedich-684	97	20	,	,	PUNCT
biomedich-684	97	21	as	as	SCONJ
biomedich-684	97	22	illustrated	illustrate	VERB
biomedich-684	97	23	in	in	ADP
biomedich-684	97	24	figure	figure	NOUN
biomedich-684	97	25	01	01	NUM
biomedich-684	97	26	.	.	PUNCT
biomedich-684	98	1	as	as	SCONJ
biomedich-684	98	2	shown	show	VERB
biomedich-684	98	3	in	in	ADP
biomedich-684	98	4	table	table	NOUN
biomedich-684	98	5	3	3	NUM
biomedich-684	98	6	,	,	PUNCT
biomedich-684	98	7	the	the	DET
biomedich-684	98	8	re	re	NOUN
biomedich-684	98	9	-	-	ADJ
biomedich-684	98	10	docking	docking	ADJ
biomedich-684	98	11	results	result	NOUN
biomedich-684	98	12	of	of	ADP
biomedich-684	98	13	the	the	DET
biomedich-684	98	14	standard	standard	ADJ
biomedich-684	98	15	ligands	ligand	NOUN
biomedich-684	98	16	in	in	ADP
biomedich-684	98	17	this	this	DET
biomedich-684	98	18	study	study	NOUN
biomedich-684	98	19	have	have	VERB
biomedich-684	98	20	an	an	DET
biomedich-684	98	21	rmsd	rmsd	NOUN
biomedich-684	98	22	of	of	ADP
biomedich-684	98	23	1.067	1.067	NUM
biomedich-684	98	24	å	å	X
biomedich-684	98	25	(	(	PUNCT
biomedich-684	98	26	3top	3top	NUM
biomedich-684	98	27	)	)	PUNCT
biomedich-684	98	28	;	;	PUNCT
biomedich-684	98	29	0.537976	0.537976	NUM
biomedich-684	98	30	å	å	PROPN
biomedich-684	98	31	(	(	PUNCT
biomedich-684	98	32	2rgu	2rgu	NUM
biomedich-684	98	33	)	)	PUNCT
biomedich-684	98	34	;	;	PUNCT
biomedich-684	98	35	0.67436	0.67436	NUM
biomedich-684	98	36	å	å	PROPN
biomedich-684	98	37	(	(	PUNCT
biomedich-684	98	38	5y2o	5y2o	NOUN
biomedich-684	98	39	)	)	PUNCT
biomedich-684	98	40	;	;	PUNCT
biomedich-684	98	41	and	and	CCONJ
biomedich-684	98	42	0.573135	0.573135	NUM
biomedich-684	98	43	å	å	PROPN
biomedich-684	98	44	(	(	PUNCT
biomedich-684	98	45	7vsi	7vsi	NOUN
biomedich-684	98	46	)	)	PUNCT
biomedich-684	98	47	.	.	PUNCT
biomedich-684	99	1	from	from	ADP
biomedich-684	99	2	the	the	DET
biomedich-684	99	3	validation	validation	NOUN
biomedich-684	99	4	results	result	NOUN
biomedich-684	99	5	carried	carry	VERB
biomedich-684	99	6	out	out	ADP
biomedich-684	99	7	it	it	PRON
biomedich-684	99	8	can	can	AUX
biomedich-684	99	9	be	be	AUX
biomedich-684	99	10	seen	see	VERB
biomedich-684	99	11	that	that	SCONJ
biomedich-684	99	12	the	the	DET
biomedich-684	99	13	rmsd	rmsd	NOUN
biomedich-684	99	14	is	be	AUX
biomedich-684	99	15	qualified	qualified	ADJ
biomedich-684	99	16	as	as	SCONJ
biomedich-684	99	17	it	it	PRON
biomedich-684	99	18	is	be	AUX
biomedich-684	99	19	<	<	X
biomedich-684	99	20	2	2	NUM
biomedich-684	99	21	å	å	NOUN
biomedich-684	99	22	.	.	PUNCT
biomedich-684	100	1	physicochemical	physicochemical	ADJ
biomedich-684	100	2	analysis	analysis	NOUN
biomedich-684	100	3	drug	drug	NOUN
biomedich-684	100	4	-	-	PUNCT
biomedich-684	100	5	likeness	likeness	NOUN
biomedich-684	100	6	screening	screen	VERB
biomedich-684	100	7	qualitatively	qualitatively	ADV
biomedich-684	100	8	assesses	assess	VERB
biomedich-684	100	9	the	the	DET
biomedich-684	100	10	possibility	possibility	NOUN
biomedich-684	100	11	of	of	ADP
biomedich-684	100	12	a	a	DET
biomedich-684	100	13	molecule	molecule	NOUN
biomedich-684	100	14	becoming	become	VERB
biomedich-684	100	15	an	an	DET
biomedich-684	100	16	oral	oral	ADJ
biomedich-684	100	17	drug	drug	NOUN
biomedich-684	100	18	regarding	regard	VERB
biomedich-684	100	19	bioavailability	bioavailability	NOUN
biomedich-684	100	20	(	(	PUNCT
biomedich-684	100	21	santos	santos	PROPN
biomedich-684	100	22	,	,	PUNCT
biomedich-684	100	23	g.b	g.b	PROPN
biomedich-684	100	24	;	;	PUNCT
biomedich-684	100	25	ganesan	ganesan	PROPN
biomedich-684	100	26	,	,	PUNCT
biomedich-684	100	27	a	a	PRON
biomedich-684	100	28	;	;	PUNCT
biomedich-684	100	29	emery	emery	PROPN
biomedich-684	100	30	,	,	PUNCT
biomedich-684	100	31	2016	2016	NUM
biomedich-684	100	32	)	)	PUNCT
biomedich-684	100	33	.	.	PUNCT
biomedich-684	101	1	lipinski	lipinski	PROPN
biomedich-684	101	2	’s	’s	PART
biomedich-684	101	3	“	"	PUNCT
biomedich-684	101	4	rule	rule	NOUN
biomedich-684	101	5	of	of	ADP
biomedich-684	101	6	five	five	NUM
biomedich-684	101	7	”	"	PUNCT
biomedich-684	101	8	highlights	highlight	NOUN
biomedich-684	101	9	possible	possible	ADJ
biomedich-684	101	10	bioavailability	bioavailability	NOUN
biomedich-684	101	11	problems	problem	NOUN
biomedich-684	101	12	if	if	SCONJ
biomedich-684	101	13	two	two	NUM
biomedich-684	101	14	or	or	CCONJ
biomedich-684	101	15	more	more	ADJ
biomedich-684	101	16	properties	property	NOUN
biomedich-684	101	17	are	be	AUX
biomedich-684	101	18	violated	violate	VERB
biomedich-684	101	19	.	.	PUNCT
biomedich-684	102	1	lipinski	lipinski	PROPN
biomedich-684	102	2	's	's	PART
biomedich-684	102	3	“	"	PUNCT
biomedich-684	102	4	rule	rule	NOUN
biomedich-684	102	5	of	of	ADP
biomedich-684	102	6	five	five	NUM
biomedich-684	102	7	”	"	PUNCT
biomedich-684	102	8	is	be	AUX
biomedich-684	102	9	an	an	DET
biomedich-684	102	10	experimental	experimental	ADJ
biomedich-684	102	11	and	and	CCONJ
biomedich-684	102	12	computational	computational	ADJ
biomedich-684	102	13	method	method	NOUN
biomedich-684	102	14	to	to	PART
biomedich-684	102	15	estimate	estimate	VERB
biomedich-684	102	16	solubility	solubility	NOUN
biomedich-684	102	17	,	,	PUNCT
biomedich-684	102	18	membrane	membrane	NOUN
biomedich-684	102	19	permeability	permeability	NOUN
biomedich-684	102	20	,	,	PUNCT
biomedich-684	102	21	and	and	CCONJ
biomedich-684	102	22	efficacy	efficacy	NOUN
biomedich-684	102	23	in	in	ADP
biomedich-684	102	24	the	the	DET
biomedich-684	102	25	drug	drug	NOUN
biomedich-684	102	26	development	development	NOUN
biomedich-684	102	27	setting	setting	NOUN
biomedich-684	102	28	.	.	PUNCT
biomedich-684	103	1	according	accord	VERB
biomedich-684	103	2	to	to	ADP
biomedich-684	103	3	lipinski	lipinski	PROPN
biomedich-684	103	4	(	(	PUNCT
biomedich-684	103	5	lipinski	lipinski	PROPN
biomedich-684	103	6	et	et	PROPN
biomedich-684	103	7	al	al	PROPN
biomedich-684	103	8	.	.	PROPN
biomedich-684	103	9	,	,	PUNCT
biomedich-684	103	10	2001	2001	NUM
biomedich-684	103	11	)	)	PUNCT
biomedich-684	103	12	,	,	PUNCT
biomedich-684	103	13	a	a	DET
biomedich-684	103	14	compound	compound	NOUN
biomedich-684	103	15	can	can	AUX
biomedich-684	103	16	be	be	AUX
biomedich-684	103	17	used	use	VERB
biomedich-684	103	18	as	as	ADP
biomedich-684	103	19	a	a	DET
biomedich-684	103	20	drug	drug	NOUN
biomedich-684	103	21	candidate	candidate	NOUN
biomedich-684	103	22	if	if	SCONJ
biomedich-684	103	23	it	it	PRON
biomedich-684	103	24	has	have	VERB
biomedich-684	103	25	a	a	DET
biomedich-684	103	26	molecular	molecular	ADJ
biomedich-684	103	27	weight	weight	NOUN
biomedich-684	103	28	of	of	ADP
biomedich-684	103	29	less	less	ADJ
biomedich-684	103	30	than	than	ADP
biomedich-684	103	31	500	500	NUM
biomedich-684	103	32	g	g	NOUN
biomedich-684	103	33	/	/	SYM
biomedich-684	103	34	mol	mol	PROPN
biomedich-684	103	35	,	,	PUNCT
biomedich-684	103	36	a	a	DET
biomedich-684	103	37	log	log	NOUN
biomedich-684	103	38	p	p	NOUN
biomedich-684	103	39	of	of	ADP
biomedich-684	103	40	less	less	ADJ
biomedich-684	103	41	than	than	ADP
biomedich-684	103	42	5	5	NUM
biomedich-684	103	43	,	,	PUNCT
biomedich-684	103	44	at	at	ADV
biomedich-684	103	45	least	least	ADV
biomedich-684	103	46	one	one	NUM
biomedich-684	103	47	h	h	NOUN
biomedich-684	103	48	-	-	PUNCT
biomedich-684	103	49	bond	bond	NOUN
biomedich-684	103	50	donor	donor	NOUN
biomedich-684	103	51	of	of	ADP
biomedich-684	103	52	less	less	ADJ
biomedich-684	103	53	than	than	ADP
biomedich-684	103	54	5	5	NUM
biomedich-684	103	55	,	,	PUNCT
biomedich-684	103	56	and	and	CCONJ
biomedich-684	103	57	at	at	ADV
biomedich-684	103	58	least	least	ADV
biomedich-684	103	59	one	one	NUM
biomedich-684	103	60	h	h	NOUN
biomedich-684	103	61	-	-	PUNCT
biomedich-684	103	62	bond	bond	NOUN
biomedich-684	103	63	acceptor	acceptor	NOUN
biomedich-684	103	64	of	of	ADP
biomedich-684	103	65	less	less	ADJ
biomedich-684	103	66	than	than	ADP
biomedich-684	103	67	10	10	NUM
biomedich-684	103	68	.	.	PUNCT
biomedich-684	104	1	according	accord	VERB
biomedich-684	104	2	to	to	ADP
biomedich-684	104	3	table	table	NOUN
biomedich-684	104	4	4	4	NUM
biomedich-684	104	5	,	,	PUNCT
biomedich-684	104	6	the	the	DET
biomedich-684	104	7	four	four	NUM
biomedich-684	104	8	compounds	compound	NOUN
biomedich-684	104	9	from	from	ADP
biomedich-684	104	10	the	the	DET
biomedich-684	104	11	stem	stem	NOUN
biomedich-684	104	12	bark	bark	NOUN
biomedich-684	104	13	of	of	ADP
biomedich-684	104	14	the	the	DET
biomedich-684	104	15	faloak	faloak	NOUN
biomedich-684	104	16	plant	plant	NOUN
biomedich-684	104	17	can	can	AUX
biomedich-684	104	18	be	be	AUX
biomedich-684	104	19	considered	consider	VERB
biomedich-684	104	20	as	as	ADP
biomedich-684	104	21	new	new	ADJ
biomedich-684	104	22	drug	drug	NOUN
biomedich-684	104	23	candidates	candidate	NOUN
biomedich-684	104	24	as	as	ADP
biomedich-684	104	25	antidiabetics	antidiabetic	NOUN
biomedich-684	104	26	.	.	PUNCT
biomedich-684	105	1	however	however	ADV
biomedich-684	105	2	,	,	PUNCT
biomedich-684	105	3	scopoletin	scopoletin	PROPN
biomedich-684	105	4	shows	show	VERB
biomedich-684	105	5	results	result	NOUN
biomedich-684	105	6	that	that	PRON
biomedich-684	105	7	fulfil	fulfil	VERB
biomedich-684	105	8	all	all	DET
biomedich-684	105	9	lipinski	lipinski	PROPN
biomedich-684	105	10	's	's	PART
biomedich-684	105	11	rules	rule	NOUN
biomedich-684	105	12	,	,	PUNCT
biomedich-684	105	13	while	while	SCONJ
biomedich-684	105	14	the	the	DET
biomedich-684	105	15	other	other	ADJ
biomedich-684	105	16	bioactive	bioactive	NOUN
biomedich-684	105	17	compounds	compound	NOUN
biomedich-684	105	18	have	have	VERB
biomedich-684	105	19	some	some	DET
biomedich-684	105	20	rules	rule	NOUN
biomedich-684	105	21	that	that	PRON
biomedich-684	105	22	are	be	AUX
biomedich-684	105	23	not	not	PART
biomedich-684	105	24	fulfilled	fulfil	VERB
biomedich-684	105	25	.	.	PUNCT
biomedich-684	106	1	however	however	ADV
biomedich-684	106	2	,	,	PUNCT
biomedich-684	106	3	this	this	DET
biomedich-684	106	4	rule	rule	NOUN
biomedich-684	106	5	does	do	AUX
biomedich-684	106	6	not	not	PART
biomedich-684	106	7	predict	predict	VERB
biomedich-684	106	8	whether	whether	SCONJ
biomedich-684	106	9	a	a	DET
biomedich-684	106	10	compound	compound	NOUN
biomedich-684	106	11	is	be	AUX
biomedich-684	106	12	pharmacologically	pharmacologically	ADV
biomedich-684	106	13	active	active	ADJ
biomedich-684	106	14	(	(	PUNCT
biomedich-684	106	15	kowalska	kowalska	NOUN
biomedich-684	106	16	et	et	PROPN
biomedich-684	106	17	al	al	PROPN
biomedich-684	106	18	.	.	PROPN
biomedich-684	106	19	,	,	PUNCT
biomedich-684	106	20	2018	2018	NUM
biomedich-684	106	21	)	)	PUNCT
biomedich-684	106	22	.	.	PUNCT
biomedich-684	107	1	molecular	molecular	ADJ
biomedich-684	107	2	docking	docking	NOUN
biomedich-684	107	3	before	before	ADP
biomedich-684	107	4	molecular	molecular	ADJ
biomedich-684	107	5	docking	docking	NOUN
biomedich-684	107	6	,	,	PUNCT
biomedich-684	107	7	all	all	PRON
biomedich-684	107	8	bioactive	bioactive	VERB
biomedich-684	107	9	compounds	compound	NOUN
biomedich-684	107	10	from	from	ADP
biomedich-684	107	11	the	the	DET
biomedich-684	107	12	stem	stem	NOUN
biomedich-684	107	13	bark	bark	NOUN
biomedich-684	107	14	of	of	ADP
biomedich-684	107	15	the	the	DET
biomedich-684	107	16	faloak	faloak	NOUN
biomedich-684	107	17	plant	plant	NOUN
biomedich-684	107	18	were	be	AUX
biomedich-684	107	19	prepared	prepare	VERB
biomedich-684	107	20	using	use	VERB
biomedich-684	107	21	the	the	DET
biomedich-684	107	22	molegro	molegro	ADJ
biomedich-684	107	23	virtual	virtual	ADJ
biomedich-684	107	24	docker	docker	PROPN
biomedich-684	107	25	application	application	NOUN
biomedich-684	107	26	.	.	PUNCT
biomedich-684	108	1	the	the	DET
biomedich-684	108	2	results	result	NOUN
biomedich-684	108	3	obtained	obtain	VERB
biomedich-684	108	4	three	three	NUM
biomedich-684	108	5	bioactive	bioactive	ADJ
biomedich-684	108	6	compounds	compound	NOUN
biomedich-684	108	7	with	with	ADP
biomedich-684	108	8	potential	potential	NOUN
biomedich-684	108	9	as	as	ADP
biomedich-684	108	10	antidiabetics	antidiabetic	NOUN
biomedich-684	108	11	in	in	ADP
biomedich-684	108	12	dpp	dpp	PROPN
biomedich-684	108	13	iv	iv	NUM
biomedich-684	108	14	inhibitors	inhibitor	NOUN
biomedich-684	108	15	.	.	PUNCT
biomedich-684	109	1	bioactive	bioactive	VERB
biomedich-684	109	2	compounds	compound	NOUN
biomedich-684	109	3	of	of	ADP
biomedich-684	109	4	faloak	faloak	NOUN
biomedich-684	109	5	plants	plant	NOUN
biomedich-684	109	6	that	that	PRON
biomedich-684	109	7	have	have	VERB
biomedich-684	109	8	potential	potential	NOUN
biomedich-684	109	9	in	in	ADP
biomedich-684	109	10	dpp	dpp	NOUN
biomedich-684	109	11	iv	iv	NUM
biomedich-684	109	12	inhibitors	inhibitor	NOUN
biomedich-684	109	13	on	on	ADP
biomedich-684	109	14	the	the	DET
biomedich-684	109	15	target	target	NOUN
biomedich-684	109	16	protein	protein	NOUN
biomedich-684	109	17	2rgu	2rgu	PROPN
biomedich-684	109	18	are	be	AUX
biomedich-684	109	19	β	β	X
biomedich-684	109	20	-	-	NOUN
biomedich-684	109	21	sitosterol	sitosterol	NOUN
biomedich-684	109	22	with	with	ADP
biomedich-684	109	23	a	a	DET
biomedich-684	109	24	score	score	NOUN
biomedich-684	109	25	value	value	NOUN
biomedich-684	109	26	(	(	PUNCT
biomedich-684	109	27	98.8838	98.8838	NUM
biomedich-684	109	28	)	)	PUNCT
biomedich-684	109	29	compared	compare	VERB
biomedich-684	109	30	to	to	ADP
biomedich-684	109	31	the	the	DET
biomedich-684	109	32	comparison	comparison	NOUN
biomedich-684	109	33	compounds	compound	VERB
biomedich-684	109	34	alogliptin	alogliptin	NOUN
biomedich-684	109	35	(	(	PUNCT
biomedich-684	109	36	-94.7326	-94.7326	NUM
biomedich-684	109	37	)	)	PUNCT
biomedich-684	109	38	,	,	PUNCT
biomedich-684	109	39	linagliptin	linagliptin	PROPN
biomedich-684	109	40	(	(	PUNCT
biomedich-684	109	41	-93.8655	-93.8655	NUM
biomedich-684	109	42	)	)	PUNCT
biomedich-684	109	43	and	and	CCONJ
biomedich-684	109	44	sitagliptin	sitagliptin	NOUN
biomedich-684	109	45	(	(	PUNCT
biomedich-684	109	46	-87.8399	-87.8399	INTJ
biomedich-684	109	47	)	)	PUNCT
biomedich-684	109	48	;	;	PUNCT
biomedich-684	109	49	catechin	catechin	NOUN
biomedich-684	109	50	(	(	PUNCT
biomedich-684	109	51	-83.4336	-83.4336	SYM
biomedich-684	109	52	)	)	PUNCT
biomedich-684	109	53	and	and	CCONJ
biomedich-684	109	54	epicatechin	epicatechin	NOUN
biomedich-684	109	55	(	(	PUNCT
biomedich-684	109	56	-83.9022	-83.9022	PUNCT
biomedich-684	109	57	)	)	PUNCT
biomedich-684	109	58	compared	compare	VERB
biomedich-684	109	59	to	to	ADP
biomedich-684	109	60	the	the	DET
biomedich-684	109	61	comparator	comparator	NOUN
biomedich-684	109	62	compounds	compound	NOUN
biomedich-684	109	63	vildagliptin	vildagliptin	NOUN
biomedich-684	109	64	(	(	PUNCT
biomedich-684	109	65	-78.2888	-78.2888	NUM
biomedich-684	109	66	)	)	PUNCT
biomedich-684	109	67	and	and	CCONJ
biomedich-684	109	68	saxagliptin	saxagliptin	NOUN
biomedich-684	109	69	(	(	PUNCT
biomedich-684	109	70	66.9827	66.9827	NUM
biomedich-684	109	71	)	)	PUNCT
biomedich-684	109	72	.	.	PUNCT
biomedich-684	110	1	table	table	NOUN
biomedich-684	110	2	5	5	NUM
biomedich-684	110	3	shows	show	VERB
biomedich-684	110	4	the	the	DET
biomedich-684	110	5	full	full	ADJ
biomedich-684	110	6	molecular	molecular	ADJ
biomedich-684	110	7	docking	docking	NOUN
biomedich-684	110	8	results	result	NOUN
biomedich-684	110	9	.	.	PUNCT
biomedich-684	111	1	visualization	visualization	VERB
biomedich-684	111	2	the	the	DET
biomedich-684	111	3	visualization	visualization	NOUN
biomedich-684	111	4	of	of	ADP
biomedich-684	111	5	2d	2d	NOUN
biomedich-684	111	6	images	image	NOUN
biomedich-684	111	7	of	of	ADP
biomedich-684	111	8	the	the	DET
biomedich-684	111	9	three	three	NUM
biomedich-684	111	10	bioactive	bioactive	ADJ
biomedich-684	111	11	compounds	compound	NOUN
biomedich-684	111	12	from	from	ADP
biomedich-684	111	13	the	the	DET
biomedich-684	111	14	stem	stem	NOUN
biomedich-684	111	15	bark	bark	NOUN
biomedich-684	111	16	of	of	ADP
biomedich-684	111	17	the	the	DET
biomedich-684	111	18	faloak	faloak	NOUN
biomedich-684	111	19	plant	plant	NOUN
biomedich-684	111	20	is	be	AUX
biomedich-684	111	21	possible	possible	ADJ
biomedich-684	111	22	due	due	ADP
biomedich-684	111	23	to	to	ADP
biomedich-684	111	24	their	their	PRON
biomedich-684	111	25	hydrogen	hydrogen	NOUN
biomedich-684	111	26	bond	bond	NOUN
biomedich-684	111	27	interactions	interaction	NOUN
biomedich-684	111	28	with	with	ADP
biomedich-684	111	29	amino	amino	NOUN
biomedich-684	111	30	acid	acid	NOUN
biomedich-684	111	31	residues	residue	NOUN
biomedich-684	111	32	.	.	PUNCT
biomedich-684	112	1	hydrogen	hydrogen	NOUN
biomedich-684	112	2	bonds	bond	NOUN
biomedich-684	112	3	are	be	AUX
biomedich-684	112	4	known	know	VERB
biomedich-684	112	5	to	to	PART
biomedich-684	112	6	be	be	AUX
biomedich-684	112	7	strong	strong	ADJ
biomedich-684	112	8	bonds	bond	NOUN
biomedich-684	112	9	,	,	PUNCT
biomedich-684	112	10	although	although	SCONJ
biomedich-684	112	11	not	not	PART
biomedich-684	112	12	as	as	ADV
biomedich-684	112	13	strong	strong	ADJ
biomedich-684	112	14	as	as	ADP
biomedich-684	112	15	covalent	covalent	ADJ
biomedich-684	112	16	bonds	bond	NOUN
biomedich-684	112	17	.	.	PUNCT
biomedich-684	113	1	the	the	DET
biomedich-684	113	2	selection	selection	NOUN
biomedich-684	113	3	of	of	ADP
biomedich-684	113	4	hydrogen	hydrogen	NOUN
biomedich-684	113	5	bonds	bond	NOUN
biomedich-684	113	6	as	as	ADP
biomedich-684	113	7	a	a	DET
biomedich-684	113	8	metric	metric	NOUN
biomedich-684	113	9	in	in	ADP
biomedich-684	113	10	this	this	DET
biomedich-684	113	11	study	study	NOUN
biomedich-684	113	12	is	be	AUX
biomedich-684	113	13	predicated	predicate	VERB
biomedich-684	113	14	on	on	ADP
biomedich-684	113	15	their	their	PRON
biomedich-684	113	16	capacity	capacity	NOUN
biomedich-684	113	17	to	to	PART
biomedich-684	113	18	influence	influence	VERB
biomedich-684	113	19	the	the	DET
biomedich-684	113	20	physical	physical	ADJ
biomedich-684	113	21	and	and	CCONJ
biomedich-684	113	22	chemical	chemical	NOUN
biomedich-684	113	23	properties	property	NOUN
biomedich-684	113	24	of	of	ADP
biomedich-684	113	25	compounds	compound	NOUN
biomedich-684	113	26	,	,	PUNCT
biomedich-684	113	27	including	include	VERB
biomedich-684	113	28	boiling	boiling	NOUN
biomedich-684	113	29	point	point	NOUN
biomedich-684	113	30	,	,	PUNCT
biomedich-684	113	31	solubility	solubility	NOUN
biomedich-684	113	32	in	in	ADP
biomedich-684	113	33	water	water	NOUN
biomedich-684	113	34	,	,	PUNCT
biomedich-684	113	35	the	the	DET
biomedich-684	113	36	ability	ability	NOUN
biomedich-684	113	37	to	to	PART
biomedich-684	113	38	form	form	VERB
biomedich-684	113	39	chelates	chelate	NOUN
biomedich-684	113	40	,	,	PUNCT
biomedich-684	113	41	and	and	CCONJ
biomedich-684	113	42	acidity	acidity	NOUN
biomedich-684	113	43	(	(	PUNCT
biomedich-684	113	44	ph	ph	NOUN
biomedich-684	113	45	)	)	PUNCT
biomedich-684	113	46	.	.	PUNCT
biomedich-684	114	1	moreover	moreover	ADV
biomedich-684	114	2	,	,	PUNCT
biomedich-684	114	3	hydrogen	hydrogen	NOUN
biomedich-684	114	4	bonds	bond	NOUN
biomedich-684	114	5	have	have	AUX
biomedich-684	114	6	been	be	AUX
biomedich-684	114	7	demonstrated	demonstrate	VERB
biomedich-684	114	8	to	to	PART
biomedich-684	114	9	impact	impact	VERB
biomedich-684	114	10	the	the	DET
biomedich-684	114	11	biological	biological	ADJ
biomedich-684	114	12	activity	activity	NOUN
biomedich-684	114	13	of	of	ADP
biomedich-684	114	14	drugs	drug	NOUN
biomedich-684	114	15	(	(	PUNCT
biomedich-684	114	16	noolvi	noolvi	PROPN
biomedich-684	114	17	&	&	CCONJ
biomedich-684	114	18	patel	patel	PROPN
biomedich-684	114	19	,	,	PUNCT
biomedich-684	114	20	2013	2013	NUM
biomedich-684	114	21	)	)	PUNCT
biomedich-684	114	22	.	.	PUNCT
biomedich-684	115	1	beta	beta	NOUN
biomedich-684	115	2	cytosterol	cytosterol	NOUN
biomedich-684	115	3	hydrogen	hydrogen	NOUN
biomedich-684	115	4	bonds	bond	NOUN
biomedich-684	115	5	(	(	PUNCT
biomedich-684	115	6	figure	figure	NOUN
biomedich-684	115	7	02	02	NUM
biomedich-684	115	8	)	)	PUNCT
biomedich-684	115	9	have	have	AUX
biomedich-684	115	10	been	be	AUX
biomedich-684	115	11	observed	observe	VERB
biomedich-684	115	12	to	to	PART
biomedich-684	115	13	occur	occur	VERB
biomedich-684	115	14	specifically	specifically	ADV
biomedich-684	115	15	at	at	ADP
biomedich-684	115	16	the	the	DET
biomedich-684	115	17	amino	amino	NOUN
biomedich-684	115	18	acid	acid	NOUN
biomedich-684	115	19	residue	residue	NOUN
biomedich-684	115	20	asp	asp	NOUN
biomedich-684	115	21	545	545	NUM
biomedich-684	115	22	,	,	PUNCT
biomedich-684	115	23	while	while	SCONJ
biomedich-684	115	24	catechin	catechin	NOUN
biomedich-684	115	25	hydrogen	hydrogen	NOUN
biomedich-684	115	26	bonds	bond	NOUN
biomedich-684	115	27	(	(	PUNCT
biomedich-684	115	28	figure	figure	NOUN
biomedich-684	115	29	03	03	NUM
biomedich-684	115	30	)	)	PUNCT
biomedich-684	115	31	have	have	AUX
biomedich-684	115	32	been	be	AUX
biomedich-684	115	33	observed	observe	VERB
biomedich-684	115	34	to	to	PART
biomedich-684	115	35	occur	occur	VERB
biomedich-684	115	36	at	at	ADP
biomedich-684	115	37	amino	amino	NOUN
biomedich-684	115	38	acid	acid	NOUN
biomedich-684	115	39	residues	residue	NOUN
biomedich-684	115	40	trp	trp	PROPN
biomedich-684	115	41	269	269	NUM
biomedich-684	115	42	and	and	CCONJ
biomedich-684	115	43	asn	asn	PROPN
biomedich-684	115	44	710	710	NUM
biomedich-684	115	45	.	.	PUNCT
biomedich-684	116	1	as	as	ADP
biomedich-684	116	2	for	for	ADP
biomedich-684	116	3	the	the	DET
biomedich-684	116	4	bioactive	bioactive	NOUN
biomedich-684	116	5	compound	compound	NOUN
biomedich-684	116	6	epicathecin	epicathecin	PROPN
biomedich-684	116	7	(	(	PUNCT
biomedich-684	116	8	figure	figure	NOUN
biomedich-684	116	9	04	04	NUM
biomedich-684	116	10	)	)	PUNCT
biomedich-684	116	11	,	,	PUNCT
biomedich-684	116	12	hydrogen	hydrogen	NOUN
biomedich-684	116	13	bonding	bonding	NOUN
biomedich-684	116	14	has	have	AUX
biomedich-684	116	15	been	be	AUX
biomedich-684	116	16	observed	observe	VERB
biomedich-684	116	17	to	to	PART
biomedich-684	116	18	occur	occur	VERB
biomedich-684	116	19	at	at	ADP
biomedich-684	116	20	amino	amino	NOUN
biomedich-684	116	21	acid	acid	NOUN
biomedich-684	116	22	residues	residue	NOUN
biomedich-684	116	23	trp	trp	NOUN
biomedich-684	116	24	629	629	NUM
biomedich-684	116	25	and	and	CCONJ
biomedich-684	116	26	asn	asn	PROPN
biomedich-684	116	27	710	710	NUM
biomedich-684	116	28	.	.	PUNCT
biomedich-684	117	1	in	in	ADP
biomedich-684	117	2	silico	silico	NOUN
biomedich-684	117	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	117	4	parameter	parameter	NOUN
biomedich-684	117	5	prediction	prediction	NOUN
biomedich-684	117	6	(	(	PUNCT
biomedich-684	117	7	admet	admet	PROPN
biomedich-684	117	8	)	)	PUNCT
biomedich-684	117	9	the	the	DET
biomedich-684	117	10	results	result	NOUN
biomedich-684	117	11	of	of	ADP
biomedich-684	117	12	admet	admet	ADJ
biomedich-684	117	13	prediction	prediction	NOUN
biomedich-684	117	14	were	be	AUX
biomedich-684	117	15	obtained	obtain	VERB
biomedich-684	117	16	by	by	ADP
biomedich-684	117	17	entering	enter	VERB
biomedich-684	117	18	the	the	DET
biomedich-684	117	19	isomeric	isomeric	ADJ
biomedich-684	117	20	smile	smile	NOUN
biomedich-684	117	21	data	datum	NOUN
biomedich-684	117	22	of	of	ADP
biomedich-684	117	23	bioactive	bioactive	ADJ
biomedich-684	117	24	compounds	compound	NOUN
biomedich-684	117	25	from	from	ADP
biomedich-684	117	26	sterculia	sterculia	NOUN
biomedich-684	117	27	quadrifida	quadrifida	PROPN
biomedich-684	117	28	r.br	r.br	NOUN
biomedich-684	117	29	stem	stem	NOUN
biomedich-684	117	30	bark	bark	NOUN
biomedich-684	117	31	on	on	ADP
biomedich-684	117	32	the	the	DET
biomedich-684	117	33	pkcsm	pkcsm	NOUN
biomedich-684	117	34	utami	utami	NOUN
biomedich-684	117	35	et	et	PROPN
biomedich-684	117	36	al	al	PROPN
biomedich-684	117	37	.	.	PROPN
biomedich-684	118	1	–	–	PUNCT
biomedich-684	118	2	antidiabetic	antidiabetic	ADJ
biomedich-684	118	3	activity	activity	NOUN
biomedich-684	118	4	of	of	ADP
biomedich-684	118	5	faloak	faloak	NOUN
biomedich-684	118	6	stem	stem	NOUN
biomedich-684	118	7	bark	bark	NOUN
biomedich-684	118	8	183	183	NUM
biomedich-684	118	9	website	website	NOUN
biomedich-684	118	10	.	.	PUNCT
biomedich-684	119	1	admet	admet	PROPN
biomedich-684	119	2	prediction	prediction	NOUN
biomedich-684	119	3	is	be	AUX
biomedich-684	119	4	carried	carry	VERB
biomedich-684	119	5	out	out	ADP
biomedich-684	119	6	to	to	PART
biomedich-684	119	7	analyze	analyze	VERB
biomedich-684	119	8	the	the	DET
biomedich-684	119	9	secondary	secondary	ADJ
biomedich-684	119	10	metabolites	metabolite	NOUN
biomedich-684	119	11	of	of	ADP
biomedich-684	119	12	sterculia	sterculia	NOUN
biomedich-684	119	13	quadrifida	quadrifida	PROPN
biomedich-684	119	14	r.br	r.br	NOUN
biomedich-684	119	15	so	so	SCONJ
biomedich-684	119	16	that	that	SCONJ
biomedich-684	119	17	absorption	absorption	NOUN
biomedich-684	119	18	,	,	PUNCT
biomedich-684	119	19	distribution	distribution	NOUN
biomedich-684	119	20	,	,	PUNCT
biomedich-684	119	21	metabolism	metabolism	NOUN
biomedich-684	119	22	,	,	PUNCT
biomedich-684	119	23	excretion	excretion	NOUN
biomedich-684	119	24	and	and	CCONJ
biomedich-684	119	25	toxicity	toxicity	NOUN
biomedich-684	119	26	are	be	AUX
biomedich-684	119	27	known	know	VERB
biomedich-684	119	28	.	.	PUNCT
biomedich-684	120	1	the	the	DET
biomedich-684	120	2	results	result	NOUN
biomedich-684	120	3	of	of	ADP
biomedich-684	120	4	the	the	DET
biomedich-684	120	5	admet	admet	NOUN
biomedich-684	120	6	prediction	prediction	NOUN
biomedich-684	120	7	are	be	AUX
biomedich-684	120	8	shown	show	VERB
biomedich-684	120	9	in	in	ADP
biomedich-684	120	10	table	table	NOUN
biomedich-684	120	11	6	6	NUM
biomedich-684	120	12	.	.	PUNCT
biomedich-684	121	1	absorption	absorption	NOUN
biomedich-684	121	2	a.	a.	NOUN
biomedich-684	121	3	the	the	DET
biomedich-684	121	4	aqueous	aqueous	ADJ
biomedich-684	121	5	solubility	solubility	NOUN
biomedich-684	121	6	of	of	ADP
biomedich-684	121	7	a	a	DET
biomedich-684	121	8	compound	compound	NOUN
biomedich-684	121	9	indicates	indicate	VERB
biomedich-684	121	10	the	the	DET
biomedich-684	121	11	solubility	solubility	NOUN
biomedich-684	121	12	of	of	ADP
biomedich-684	121	13	the	the	DET
biomedich-684	121	14	molecule	molecule	NOUN
biomedich-684	121	15	in	in	ADP
biomedich-684	121	16	water	water	NOUN
biomedich-684	121	17	at	at	ADP
biomedich-684	121	18	25	25	NUM
biomedich-684	121	19	°	°	NOUN
biomedich-684	121	20	c	c	NOUN
biomedich-684	121	21	.	.	PUNCT
biomedich-684	122	1	it	it	PRON
biomedich-684	122	2	is	be	AUX
biomedich-684	122	3	widely	widely	ADV
biomedich-684	122	4	acknowledged	acknowledge	VERB
biomedich-684	122	5	that	that	SCONJ
biomedich-684	122	6	fat	fat	ADJ
biomedich-684	122	7	-	-	PUNCT
biomedich-684	122	8	soluble	soluble	ADJ
biomedich-684	122	9	drugs	drug	NOUN
biomedich-684	122	10	are	be	AUX
biomedich-684	122	11	less	less	ADV
biomedich-684	122	12	well	well	ADV
biomedich-684	122	13	absorbed	absorb	VERB
biomedich-684	122	14	than	than	ADP
biomedich-684	122	15	water	water	NOUN
biomedich-684	122	16	-	-	PUNCT
biomedich-684	122	17	soluble	soluble	ADJ
biomedich-684	122	18	drugs	drug	NOUN
biomedich-684	122	19	,	,	PUNCT
biomedich-684	122	20	especially	especially	ADV
biomedich-684	122	21	when	when	SCONJ
biomedich-684	122	22	administered	administer	VERB
biomedich-684	122	23	enterally	enterally	ADV
biomedich-684	122	24	(	(	PUNCT
biomedich-684	122	25	yeni	yeni	PROPN
biomedich-684	122	26	&	&	CCONJ
biomedich-684	122	27	rachmania	rachmania	NOUN
biomedich-684	122	28	,	,	PUNCT
biomedich-684	122	29	2022	2022	NUM
biomedich-684	122	30	)	)	PUNCT
biomedich-684	122	31	.	.	PUNCT
biomedich-684	123	1	the	the	DET
biomedich-684	123	2	results	result	NOUN
biomedich-684	123	3	show	show	VERB
biomedich-684	123	4	that	that	SCONJ
biomedich-684	123	5	beta	beta	NOUN
biomedich-684	123	6	-	-	PUNCT
biomedich-684	123	7	sitosterol	sitosterol	NOUN
biomedich-684	123	8	is	be	AUX
biomedich-684	123	9	poorly	poorly	ADV
biomedich-684	123	10	soluble	soluble	ADJ
biomedich-684	123	11	.	.	PUNCT
biomedich-684	124	1	the	the	DET
biomedich-684	124	2	logarithm	logarithm	NOUN
biomedich-684	124	3	of	of	ADP
biomedich-684	124	4	the	the	DET
biomedich-684	124	5	molar	molar	ADJ
biomedich-684	124	6	concentration	concentration	NOUN
biomedich-684	124	7	(	(	PUNCT
biomedich-684	124	8	log	log	NOUN
biomedich-684	124	9	mol	mol	PROPN
biomedich-684	124	10	/	/	SYM
biomedich-684	124	11	l	l	NOUN
biomedich-684	124	12	)	)	PUNCT
biomedich-684	124	13	is	be	AUX
biomedich-684	124	14	the	the	DET
biomedich-684	124	15	accepted	accept	VERB
biomedich-684	124	16	measure	measure	NOUN
biomedich-684	124	17	of	of	ADP
biomedich-684	124	18	the	the	DET
biomedich-684	124	19	predicted	predict	VERB
biomedich-684	124	20	water	water	NOUN
biomedich-684	124	21	solubility	solubility	NOUN
biomedich-684	124	22	of	of	ADP
biomedich-684	124	23	a	a	DET
biomedich-684	124	24	compound	compound	NOUN
biomedich-684	124	25	.	.	PUNCT
biomedich-684	125	1	b.	b.	PROPN
biomedich-684	126	1	the	the	DET
biomedich-684	126	2	term	term	NOUN
biomedich-684	126	3	'	'	PUNCT
biomedich-684	126	4	caco2	caco2	NOUN
biomedich-684	126	5	permeability	permeability	NOUN
biomedich-684	126	6	'	'	PUNCT
biomedich-684	126	7	is	be	AUX
biomedich-684	126	8	employed	employ	VERB
biomedich-684	126	9	to	to	PART
biomedich-684	126	10	denote	denote	VERB
biomedich-684	126	11	the	the	DET
biomedich-684	126	12	capacity	capacity	NOUN
biomedich-684	126	13	of	of	ADP
biomedich-684	126	14	a	a	DET
biomedich-684	126	15	compound	compound	NOUN
biomedich-684	126	16	to	to	PART
biomedich-684	126	17	facilitate	facilitate	VERB
biomedich-684	126	18	the	the	DET
biomedich-684	126	19	movement	movement	NOUN
biomedich-684	126	20	of	of	ADP
biomedich-684	126	21	carbon	carbon	NOUN
biomedich-684	126	22	dioxide	dioxide	NOUN
biomedich-684	126	23	,	,	PUNCT
biomedich-684	126	24	and	and	CCONJ
biomedich-684	126	25	is	be	AUX
biomedich-684	126	26	denoted	denote	VERB
biomedich-684	126	27	by	by	ADP
biomedich-684	126	28	the	the	DET
biomedich-684	126	29	parameter	parameter	NOUN
biomedich-684	126	30	'	'	PUNCT
biomedich-684	126	31	papp	papp	NOUN
biomedich-684	126	32	'	'	PUNCT
biomedich-684	126	33	.	.	PUNCT
biomedich-684	127	1	the	the	DET
biomedich-684	127	2	value	value	NOUN
biomedich-684	127	3	of	of	ADP
biomedich-684	127	4	'	'	PUNCT
biomedich-684	127	5	papp	papp	NOUN
biomedich-684	127	6	'	'	PUNCT
biomedich-684	127	7	must	must	AUX
biomedich-684	127	8	exceed	exceed	VERB
biomedich-684	127	9	8	8	NUM
biomedich-684	127	10	x	x	SYM
biomedich-684	127	11	10	10	NUM
biomedich-684	127	12	-	-	SYM
biomedich-684	127	13	6	6	NUM
biomedich-684	127	14	cm	cm	NOUN
biomedich-684	127	15	/	/	SYM
biomedich-684	127	16	s	s	PROPN
biomedich-684	127	17	for	for	SCONJ
biomedich-684	127	18	a	a	DET
biomedich-684	127	19	compound	compound	NOUN
biomedich-684	127	20	to	to	PART
biomedich-684	127	21	be	be	AUX
biomedich-684	127	22	considered	consider	VERB
biomedich-684	127	23	to	to	PART
biomedich-684	127	24	have	have	VERB
biomedich-684	127	25	high	high	ADJ
biomedich-684	127	26	caco2	caco2	NOUN
biomedich-684	127	27	permeability	permeability	NOUN
biomedich-684	127	28	.	.	PUNCT
biomedich-684	128	1	for	for	ADP
biomedich-684	128	2	predictions	prediction	NOUN
biomedich-684	128	3	on	on	ADP
biomedich-684	128	4	pkcsm	pkcsm	NOUN
biomedich-684	128	5	,	,	PUNCT
biomedich-684	128	6	high	high	ADJ
biomedich-684	128	7	caco2	caco2	NOUN
biomedich-684	128	8	permeability	permeability	NOUN
biomedich-684	128	9	would	would	AUX
biomedich-684	128	10	result	result	VERB
biomedich-684	128	11	in	in	ADP
biomedich-684	128	12	a	a	DET
biomedich-684	128	13	value	value	NOUN
biomedich-684	128	14	of	of	ADP
biomedich-684	128	15	0.90	0.90	NUM
biomedich-684	128	16	(	(	PUNCT
biomedich-684	128	17	yeni	yeni	PROPN
biomedich-684	128	18	&	&	CCONJ
biomedich-684	128	19	rachmania	rachmania	NOUN
biomedich-684	128	20	,	,	PUNCT
biomedich-684	128	21	2022	2022	NUM
biomedich-684	128	22	)	)	PUNCT
biomedich-684	128	23	.	.	PUNCT
biomedich-684	129	1	c.	c.	NOUN
biomedich-684	130	1	the	the	DET
biomedich-684	130	2	gut	gut	NOUN
biomedich-684	130	3	is	be	AUX
biomedich-684	130	4	typically	typically	ADV
biomedich-684	130	5	the	the	DET
biomedich-684	130	6	main	main	ADJ
biomedich-684	130	7	site	site	NOUN
biomedich-684	130	8	of	of	ADP
biomedich-684	130	9	drug	drug	NOUN
biomedich-684	130	10	absorption	absorption	NOUN
biomedich-684	130	11	from	from	ADP
biomedich-684	130	12	orally	orally	ADV
biomedich-684	130	13	administered	administer	VERB
biomedich-684	130	14	solutions	solution	NOUN
biomedich-684	130	15	.	.	PUNCT
biomedich-684	131	1	the	the	DET
biomedich-684	131	2	present	present	ADJ
biomedich-684	131	3	method	method	NOUN
biomedich-684	131	4	was	be	AUX
biomedich-684	131	5	developed	develop	VERB
biomedich-684	131	6	estimate	estimate	VERB
biomedich-684	131	7	the	the	DET
biomedich-684	131	8	proportion	proportion	NOUN
biomedich-684	131	9	of	of	ADP
biomedich-684	131	10	compounds	compound	NOUN
biomedich-684	131	11	absorbed	absorb	VERB
biomedich-684	131	12	through	through	ADP
biomedich-684	131	13	the	the	DET
biomedich-684	131	14	small	small	ADJ
biomedich-684	131	15	intestine	intestine	NOUN
biomedich-684	131	16	.	.	PUNCT
biomedich-684	132	1	the	the	DET
biomedich-684	132	2	prediction	prediction	NOUN
biomedich-684	132	3	of	of	ADP
biomedich-684	132	4	compounds	compound	NOUN
biomedich-684	132	5	with	with	ADP
biomedich-684	132	6	favorable	favorable	ADJ
biomedich-684	132	7	intestinal	intestinal	ADJ
biomedich-684	132	8	absorption	absorption	NOUN
biomedich-684	132	9	is	be	AUX
biomedich-684	132	10	facilitated	facilitate	VERB
biomedich-684	132	11	by	by	ADP
biomedich-684	132	12	identifying	identify	VERB
biomedich-684	132	13	molecules	molecule	NOUN
biomedich-684	132	14	exhibiting	exhibit	VERB
biomedich-684	132	15	more	more	ADJ
biomedich-684	132	16	than	than	ADP
biomedich-684	132	17	30	30	NUM
biomedich-684	132	18	%	%	NOUN
biomedich-684	132	19	absorbance	absorbance	NOUN
biomedich-684	132	20	,	,	PUNCT
biomedich-684	132	21	as	as	SCONJ
biomedich-684	132	22	these	these	PRON
biomedich-684	132	23	are	be	AUX
biomedich-684	132	24	deemed	deem	VERB
biomedich-684	132	25	well	well	ADV
biomedich-684	132	26	absorbed	absorb	VERB
biomedich-684	132	27	.	.	PUNCT
biomedich-684	133	1	compounds	compound	NOUN
biomedich-684	133	2	with	with	ADP
biomedich-684	133	3	less	less	ADJ
biomedich-684	133	4	than	than	ADP
biomedich-684	133	5	30	30	NUM
biomedich-684	133	6	%	%	NOUN
biomedich-684	133	7	are	be	AUX
biomedich-684	133	8	considered	consider	VERB
biomedich-684	133	9	poorly	poorly	ADV
biomedich-684	133	10	absorbed	absorb	VERB
biomedich-684	133	11	(	(	PUNCT
biomedich-684	133	12	yeni	yeni	PROPN
biomedich-684	133	13	&	&	CCONJ
biomedich-684	133	14	rachmania	rachmania	NOUN
biomedich-684	133	15	,	,	PUNCT
biomedich-684	133	16	2022	2022	NUM
biomedich-684	133	17	)	)	PUNCT
biomedich-684	133	18	.	.	PUNCT
biomedich-684	134	1	all	all	DET
biomedich-684	134	2	compounds	compound	NOUN
biomedich-684	134	3	showed	show	VERB
biomedich-684	134	4	results	result	NOUN
biomedich-684	134	5	above	above	ADP
biomedich-684	134	6	30	30	NUM
biomedich-684	134	7	%	%	NOUN
biomedich-684	134	8	.	.	PUNCT
biomedich-684	135	1	however	however	ADV
biomedich-684	135	2	,	,	PUNCT
biomedich-684	135	3	beta	beta	NOUN
biomedich-684	135	4	-	-	PUNCT
biomedich-684	135	5	sitosterol	sitosterol	NOUN
biomedich-684	135	6	showed	show	VERB
biomedich-684	135	7	the	the	DET
biomedich-684	135	8	highest	high	ADJ
biomedich-684	135	9	results	result	NOUN
biomedich-684	135	10	to	to	PART
biomedich-684	135	11	be	be	AUX
biomedich-684	135	12	well	well	ADV
biomedich-684	135	13	absorbed	absorb	VERB
biomedich-684	135	14	.	.	PUNCT
biomedich-684	136	1	distribution	distribution	NOUN
biomedich-684	136	2	a.	a.	NOUN
biomedich-684	136	3	the	the	DET
biomedich-684	136	4	volume	volume	NOUN
biomedich-684	136	5	of	of	ADP
biomedich-684	136	6	distribution	distribution	NOUN
biomedich-684	136	7	is	be	AUX
biomedich-684	136	8	the	the	DET
biomedich-684	136	9	theoretical	theoretical	ADJ
biomedich-684	136	10	volume	volume	NOUN
biomedich-684	136	11	required	require	VERB
biomedich-684	136	12	to	to	PART
biomedich-684	136	13	distribute	distribute	VERB
biomedich-684	136	14	the	the	DET
biomedich-684	136	15	total	total	ADJ
biomedich-684	136	16	drug	drug	NOUN
biomedich-684	136	17	dose	dose	VERB
biomedich-684	136	18	to	to	PART
biomedich-684	136	19	produce	produce	VERB
biomedich-684	136	20	the	the	DET
biomedich-684	136	21	same	same	ADJ
biomedich-684	136	22	concentration	concentration	NOUN
biomedich-684	136	23	as	as	ADP
biomedich-684	136	24	in	in	ADP
biomedich-684	136	25	blood	blood	NOUN
biomedich-684	136	26	plasma	plasma	NOUN
biomedich-684	136	27	evenly	evenly	ADV
biomedich-684	136	28	.	.	PUNCT
biomedich-684	137	1	the	the	PRON
biomedich-684	137	2	higher	high	ADJ
biomedich-684	137	3	the	the	DET
biomedich-684	137	4	volume	volume	NOUN
biomedich-684	137	5	of	of	ADP
biomedich-684	137	6	distribution	distribution	NOUN
biomedich-684	137	7	value	value	NOUN
biomedich-684	137	8	,	,	PUNCT
biomedich-684	137	9	the	the	DET
biomedich-684	137	10	more	more	ADJ
biomedich-684	137	11	drug	drug	NOUN
biomedich-684	137	12	is	be	AUX
biomedich-684	137	13	distributed	distribute	VERB
biomedich-684	137	14	in	in	ADP
biomedich-684	137	15	the	the	DET
biomedich-684	137	16	tissues	tissue	NOUN
biomedich-684	137	17	in	in	ADP
biomedich-684	137	18	the	the	DET
biomedich-684	137	19	plasma	plasma	NOUN
biomedich-684	137	20	.	.	PUNCT
biomedich-684	138	1	a	a	DET
biomedich-684	138	2	value	value	NOUN
biomedich-684	138	3	of	of	ADP
biomedich-684	138	4	less	less	ADJ
biomedich-684	138	5	than	than	ADP
biomedich-684	138	6	0.71	0.71	NUM
biomedich-684	138	7	l	l	NOUN
biomedich-684	138	8	/	/	SYM
biomedich-684	138	9	kg	kg	PROPN
biomedich-684	138	10	indicates	indicate	VERB
biomedich-684	138	11	a	a	DET
biomedich-684	138	12	low	low	ADJ
biomedich-684	138	13	distribution	distribution	NOUN
biomedich-684	138	14	volume	volume	NOUN
biomedich-684	138	15	(	(	PUNCT
biomedich-684	138	16	prasetiyo	prasetiyo	NOUN
biomedich-684	138	17	et	et	PROPN
biomedich-684	138	18	al	al	PROPN
biomedich-684	138	19	.	.	PROPN
biomedich-684	138	20	,	,	PUNCT
biomedich-684	138	21	2024	2024	NUM
biomedich-684	138	22	)	)	PUNCT
biomedich-684	138	23	.	.	PUNCT
biomedich-684	139	1	catechin	catechin	PROPN
biomedich-684	139	2	and	and	CCONJ
biomedich-684	139	3	epicatechin	epicatechin	NOUN
biomedich-684	139	4	compounds	compound	NOUN
biomedich-684	139	5	had	have	VERB
biomedich-684	139	6	the	the	DET
biomedich-684	139	7	best	good	ADJ
biomedich-684	139	8	results	result	NOUN
biomedich-684	139	9	compared	compare	VERB
biomedich-684	139	10	to	to	ADP
biomedich-684	139	11	other	other	ADJ
biomedich-684	139	12	bioactive	bioactive	PROPN
biomedich-684	139	13	compounds	compound	NOUN
biomedich-684	139	14	.	.	PUNCT
biomedich-684	140	1	b.	b.	PROPN
biomedich-684	140	2	the	the	DET
biomedich-684	140	3	blood	blood	NOUN
biomedich-684	140	4	-	-	PUNCT
biomedich-684	140	5	brain	brain	NOUN
biomedich-684	140	6	barrier	barrier	NOUN
biomedich-684	140	7	(	(	PUNCT
biomedich-684	140	8	bbb	bbb	NOUN
biomedich-684	140	9	)	)	PUNCT
biomedich-684	140	10	is	be	AUX
biomedich-684	140	11	a	a	DET
biomedich-684	140	12	vital	vital	ADJ
biomedich-684	140	13	component	component	NOUN
biomedich-684	140	14	of	of	ADP
biomedich-684	140	15	the	the	DET
biomedich-684	140	16	central	central	ADJ
biomedich-684	140	17	nervous	nervous	ADJ
biomedich-684	140	18	system	system	NOUN
biomedich-684	140	19	(	(	PUNCT
biomedich-684	140	20	cns	cns	NOUN
biomedich-684	140	21	)	)	PUNCT
biomedich-684	140	22	that	that	PRON
biomedich-684	140	23	acts	act	VERB
biomedich-684	140	24	as	as	ADP
biomedich-684	140	25	a	a	DET
biomedich-684	140	26	protective	protective	ADJ
biomedich-684	140	27	barrier	barrier	NOUN
biomedich-684	140	28	against	against	ADP
biomedich-684	140	29	exogenous	exogenous	ADJ
biomedich-684	140	30	compounds	compound	NOUN
biomedich-684	140	31	.	.	PUNCT
biomedich-684	141	1	bbb	bbb	PROPN
biomedich-684	141	2	permeability	permeability	NOUN
biomedich-684	141	3	is	be	AUX
biomedich-684	141	4	defined	define	VERB
biomedich-684	141	5	as	as	ADP
biomedich-684	141	6	the	the	DET
biomedich-684	141	7	capacity	capacity	NOUN
biomedich-684	141	8	of	of	ADP
biomedich-684	141	9	a	a	DET
biomedich-684	141	10	pharmaceutical	pharmaceutical	ADJ
biomedich-684	141	11	agent	agent	NOUN
biomedich-684	141	12	to	to	PART
biomedich-684	141	13	traverse	traverse	VERB
biomedich-684	141	14	the	the	DET
biomedich-684	141	15	blood	blood	NOUN
biomedich-684	141	16	-	-	PUNCT
biomedich-684	141	17	brain	brain	NOUN
biomedich-684	141	18	barrier	barrier	NOUN
biomedich-684	141	19	.	.	PUNCT
biomedich-684	142	1	this	this	DET
biomedich-684	142	2	parameter	parameter	NOUN
biomedich-684	142	3	is	be	AUX
biomedich-684	142	4	important	important	ADJ
biomedich-684	142	5	in	in	ADP
biomedich-684	142	6	reducing	reduce	VERB
biomedich-684	142	7	adverse	adverse	ADJ
biomedich-684	142	8	effects	effect	NOUN
biomedich-684	142	9	and	and	CCONJ
biomedich-684	142	10	toxicity	toxicity	NOUN
biomedich-684	142	11	,	,	PUNCT
biomedich-684	142	12	or	or	CCONJ
biomedich-684	142	13	enhancing	enhance	VERB
biomedich-684	142	14	the	the	DET
biomedich-684	142	15	efficacy	efficacy	NOUN
biomedich-684	142	16	of	of	ADP
biomedich-684	142	17	drugs	drug	NOUN
biomedich-684	142	18	whose	whose	DET
biomedich-684	142	19	pharmacological	pharmacological	ADJ
biomedich-684	142	20	activity	activity	NOUN
biomedich-684	142	21	is	be	AUX
biomedich-684	142	22	confined	confine	VERB
biomedich-684	142	23	to	to	ADP
biomedich-684	142	24	the	the	DET
biomedich-684	142	25	brain	brain	NOUN
biomedich-684	142	26	.	.	PUNCT
biomedich-684	143	1	it	it	PRON
biomedich-684	143	2	is	be	AUX
biomedich-684	143	3	widely	widely	ADV
biomedich-684	143	4	accepted	accept	VERB
biomedich-684	143	5	that	that	SCONJ
biomedich-684	143	6	compounds	compound	VERB
biomedich-684	143	7	with	with	ADP
biomedich-684	143	8	a	a	DET
biomedich-684	143	9	logbb	logbb	NOUN
biomedich-684	143	10	greater	great	ADJ
biomedich-684	143	11	than	than	ADP
biomedich-684	143	12	0.3	0.3	NUM
biomedich-684	143	13	are	be	AUX
biomedich-684	143	14	considered	consider	VERB
biomedich-684	143	15	to	to	PART
biomedich-684	143	16	cross	cross	VERB
biomedich-684	143	17	the	the	DET
biomedich-684	143	18	blood	blood	NOUN
biomedich-684	143	19	-	-	PUNCT
biomedich-684	143	20	brain	brain	NOUN
biomedich-684	143	21	barrier	barrier	NOUN
biomedich-684	143	22	with	with	ADP
biomedich-684	143	23	ease	ease	NOUN
biomedich-684	143	24	,	,	PUNCT
biomedich-684	143	25	while	while	SCONJ
biomedich-684	143	26	those	those	PRON
biomedich-684	143	27	with	with	ADP
biomedich-684	143	28	a	a	DET
biomedich-684	143	29	logbb	logbb	NOUN
biomedich-684	143	30	less	less	ADJ
biomedich-684	143	31	than	than	ADP
biomedich-684	143	32	-1	-1	VERB
biomedich-684	143	33	are	be	AUX
biomedich-684	143	34	less	less	ADV
biomedich-684	143	35	likely	likely	ADJ
biomedich-684	143	36	to	to	PART
biomedich-684	143	37	be	be	AUX
biomedich-684	143	38	distributed	distribute	VERB
biomedich-684	143	39	to	to	ADP
biomedich-684	143	40	the	the	DET
biomedich-684	143	41	brain	brain	NOUN
biomedich-684	143	42	(	(	PUNCT
biomedich-684	143	43	prasetiyo	prasetiyo	NOUN
biomedich-684	143	44	et	et	PROPN
biomedich-684	143	45	al	al	PROPN
biomedich-684	143	46	.	.	PROPN
biomedich-684	143	47	,	,	PUNCT
biomedich-684	143	48	2024	2024	NUM
biomedich-684	143	49	)	)	PUNCT
biomedich-684	143	50	.	.	PUNCT
biomedich-684	144	1	similar	similar	ADJ
biomedich-684	144	2	to	to	ADP
biomedich-684	144	3	the	the	DET
biomedich-684	144	4	volume	volume	NOUN
biomedich-684	144	5	of	of	ADP
biomedich-684	144	6	distribution	distribution	NOUN
biomedich-684	144	7	results	result	NOUN
biomedich-684	144	8	,	,	PUNCT
biomedich-684	144	9	the	the	DET
biomedich-684	144	10	results	result	NOUN
biomedich-684	144	11	for	for	ADP
biomedich-684	144	12	catechins	catechin	NOUN
biomedich-684	144	13	and	and	CCONJ
biomedich-684	144	14	epicatechins	epicatechin	NOUN
biomedich-684	144	15	showed	show	VERB
biomedich-684	144	16	that	that	SCONJ
biomedich-684	144	17	these	these	DET
biomedich-684	144	18	compounds	compound	NOUN
biomedich-684	144	19	could	could	AUX
biomedich-684	144	20	not	not	PART
biomedich-684	144	21	cross	cross	VERB
biomedich-684	144	22	the	the	DET
biomedich-684	144	23	blood	blood	NOUN
biomedich-684	144	24	-	-	PUNCT
biomedich-684	144	25	brain	brain	NOUN
biomedich-684	144	26	barrier	barrier	NOUN
biomedich-684	144	27	.	.	PUNCT
biomedich-684	145	1	metabolism	metabolism	NOUN
biomedich-684	145	2	cytochrome	cytochrome	NOUN
biomedich-684	145	3	p450	p450	PROPN
biomedich-684	145	4	is	be	AUX
biomedich-684	145	5	an	an	DET
biomedich-684	145	6	important	important	ADJ
biomedich-684	145	7	detoxification	detoxification	NOUN
biomedich-684	145	8	enzyme	enzyme	NOUN
biomedich-684	145	9	in	in	ADP
biomedich-684	145	10	the	the	DET
biomedich-684	145	11	body	body	NOUN
biomedich-684	145	12	,	,	PUNCT
biomedich-684	145	13	mainly	mainly	ADV
biomedich-684	145	14	found	find	VERB
biomedich-684	145	15	in	in	ADP
biomedich-684	145	16	the	the	DET
biomedich-684	145	17	liver	liver	NOUN
biomedich-684	145	18	.	.	PUNCT
biomedich-684	146	1	cytochrome	cytochrome	NOUN
biomedich-684	146	2	p450	p450	PROPN
biomedich-684	146	3	oxidizes	oxidize	VERB
biomedich-684	146	4	xenobiotics	xenobiotic	NOUN
biomedich-684	146	5	to	to	PART
biomedich-684	146	6	facilitate	facilitate	VERB
biomedich-684	146	7	their	their	PRON
biomedich-684	146	8	excretion	excretion	NOUN
biomedich-684	146	9	.	.	PUNCT
biomedich-684	147	1	many	many	ADJ
biomedich-684	147	2	drugs	drug	NOUN
biomedich-684	147	3	are	be	AUX
biomedich-684	147	4	inactivated	inactivate	VERB
biomedich-684	147	5	by	by	ADP
biomedich-684	147	6	cytochrome	cytochrome	ADJ
biomedich-684	147	7	p450	p450	PROPN
biomedich-684	147	8	and	and	CCONJ
biomedich-684	147	9	some	some	PRON
biomedich-684	147	10	can	can	AUX
biomedich-684	147	11	be	be	AUX
biomedich-684	147	12	activated	activate	VERB
biomedich-684	147	13	.	.	PUNCT
biomedich-684	148	1	inhibitors	inhibitor	NOUN
biomedich-684	148	2	of	of	ADP
biomedich-684	148	3	these	these	DET
biomedich-684	148	4	enzymes	enzyme	NOUN
biomedich-684	148	5	may	may	AUX
biomedich-684	148	6	affect	affect	VERB
biomedich-684	148	7	drug	drug	NOUN
biomedich-684	148	8	metabolism	metabolism	NOUN
biomedich-684	148	9	and	and	CCONJ
biomedich-684	148	10	are	be	AUX
biomedich-684	148	11	contraindicated	contraindicate	VERB
biomedich-684	148	12	.	.	PUNCT
biomedich-684	149	1	therefore	therefore	ADV
biomedich-684	149	2	,	,	PUNCT
biomedich-684	149	3	it	it	PRON
biomedich-684	149	4	is	be	AUX
biomedich-684	149	5	important	important	ADJ
biomedich-684	149	6	to	to	PART
biomedich-684	149	7	assess	assess	VERB
biomedich-684	149	8	the	the	DET
biomedich-684	149	9	ability	ability	NOUN
biomedich-684	149	10	of	of	ADP
biomedich-684	149	11	compounds	compound	NOUN
biomedich-684	149	12	to	to	PART
biomedich-684	149	13	inhibit	inhibit	VERB
biomedich-684	149	14	cytochrome	cytochrome	NOUN
biomedich-684	149	15	p450	p450	PROPN
biomedich-684	149	16	(	(	PUNCT
biomedich-684	149	17	prasetiyo	prasetiyo	NOUN
biomedich-684	149	18	et	et	PROPN
biomedich-684	149	19	al	al	PROPN
biomedich-684	149	20	.	.	PROPN
biomedich-684	149	21	,	,	PUNCT
biomedich-684	149	22	2024	2024	NUM
biomedich-684	149	23	)	)	PUNCT
biomedich-684	149	24	.	.	PUNCT
biomedich-684	150	1	excretion	excretion	NOUN
biomedich-684	150	2	drug	drug	NOUN
biomedich-684	150	3	clearance	clearance	NOUN
biomedich-684	150	4	is	be	AUX
biomedich-684	150	5	measured	measure	VERB
biomedich-684	150	6	by	by	ADP
biomedich-684	150	7	the	the	DET
biomedich-684	150	8	proportionality	proportionality	NOUN
biomedich-684	150	9	constant	constant	ADJ
biomedich-684	150	10	cltot	cltot	PROPN
biomedich-684	150	11	,	,	PUNCT
biomedich-684	150	12	and	and	CCONJ
biomedich-684	150	13	occurs	occur	VERB
biomedich-684	150	14	mainly	mainly	ADV
biomedich-684	150	15	as	as	ADP
biomedich-684	150	16	a	a	DET
biomedich-684	150	17	combination	combination	NOUN
biomedich-684	150	18	of	of	ADP
biomedich-684	150	19	hepatic	hepatic	ADJ
biomedich-684	150	20	clearance	clearance	NOUN
biomedich-684	150	21	(	(	PUNCT
biomedich-684	150	22	metabolism	metabolism	NOUN
biomedich-684	150	23	in	in	ADP
biomedich-684	150	24	the	the	DET
biomedich-684	150	25	liver	liver	NOUN
biomedich-684	150	26	and	and	CCONJ
biomedich-684	150	27	biliary	biliary	NOUN
biomedich-684	150	28	clearance	clearance	NOUN
biomedich-684	150	29	)	)	PUNCT
biomedich-684	150	30	and	and	CCONJ
biomedich-684	150	31	renal	renal	ADJ
biomedich-684	150	32	clearance	clearance	NOUN
biomedich-684	150	33	(	(	PUNCT
biomedich-684	150	34	excretion	excretion	NOUN
biomedich-684	150	35	through	through	ADP
biomedich-684	150	36	the	the	DET
biomedich-684	150	37	kidneys	kidney	NOUN
biomedich-684	150	38	)	)	PUNCT
biomedich-684	150	39	.	.	PUNCT
biomedich-684	151	1	this	this	PRON
biomedich-684	151	2	is	be	AUX
biomedich-684	151	3	related	relate	VERB
biomedich-684	151	4	to	to	ADP
biomedich-684	151	5	bioavailability	bioavailability	NOUN
biomedich-684	151	6	,	,	PUNCT
biomedich-684	151	7	and	and	CCONJ
biomedich-684	151	8	is	be	AUX
biomedich-684	151	9	important	important	ADJ
biomedich-684	151	10	for	for	ADP
biomedich-684	151	11	determining	determine	VERB
biomedich-684	151	12	the	the	DET
biomedich-684	151	13	dose	dose	NOUN
biomedich-684	151	14	rate	rate	NOUN
biomedich-684	151	15	to	to	PART
biomedich-684	151	16	achieve	achieve	VERB
biomedich-684	151	17	steady	steady	ADJ
biomedich-684	151	18	-	-	PUNCT
biomedich-684	151	19	state	state	NOUN
biomedich-684	151	20	concentrations	concentration	NOUN
biomedich-684	151	21	.	.	PUNCT
biomedich-684	152	1	the	the	DET
biomedich-684	152	2	excretion	excretion	NOUN
biomedich-684	152	3	values	value	NOUN
biomedich-684	152	4	of	of	ADP
biomedich-684	152	5	the	the	DET
biomedich-684	152	6	test	test	NOUN
biomedich-684	152	7	compounds	compound	NOUN
biomedich-684	152	8	from	from	ADP
biomedich-684	152	9	pkcsmpharmacokinetics	pkcsmpharmacokinetic	NOUN
biomedich-684	152	10	ranged	range	VERB
biomedich-684	152	11	from	from	ADP
biomedich-684	152	12	0.99	0.99	NUM
biomedich-684	152	13	to	to	ADP
biomedich-684	152	14	1.314	1.314	NUM
biomedich-684	152	15	log	log	NOUN
biomedich-684	152	16	ml	ml	ADP
biomedich-684	152	17	/	/	SYM
biomedich-684	152	18	mln	mln	PROPN
biomedich-684	152	19	/	/	SYM
biomedich-684	152	20	kg	kg	PROPN
biomedich-684	152	21	.	.	PUNCT
biomedich-684	153	1	the	the	DET
biomedich-684	153	2	excretion	excretion	NOUN
biomedich-684	153	3	results	result	NOUN
biomedich-684	153	4	indicate	indicate	VERB
biomedich-684	153	5	that	that	SCONJ
biomedich-684	153	6	the	the	DET
biomedich-684	153	7	four	four	NUM
biomedich-684	153	8	test	test	NOUN
biomedich-684	153	9	compounds	compound	NOUN
biomedich-684	153	10	did	do	AUX
biomedich-684	153	11	not	not	PART
biomedich-684	153	12	meet	meet	VERB
biomedich-684	153	13	the	the	DET
biomedich-684	153	14	range	range	NOUN
biomedich-684	153	15	of	of	ADP
biomedich-684	153	16	total	total	ADJ
biomedich-684	153	17	clearance	clearance	NOUN
biomedich-684	153	18	values	value	NOUN
biomedich-684	153	19	.	.	PUNCT
biomedich-684	154	1	this	this	PRON
biomedich-684	154	2	suggests	suggest	VERB
biomedich-684	154	3	that	that	SCONJ
biomedich-684	154	4	the	the	DET
biomedich-684	154	5	body	body	NOUN
biomedich-684	154	6	slowly	slowly	ADV
biomedich-684	154	7	excretes	excrete	VERB
biomedich-684	154	8	the	the	DET
biomedich-684	154	9	four	four	NUM
biomedich-684	154	10	compounds	compound	NOUN
biomedich-684	154	11	(	(	PUNCT
biomedich-684	154	12	prasetiyo	prasetiyo	NOUN
biomedich-684	154	13	et	et	NOUN
biomedich-684	154	14	al	al	PROPN
biomedich-684	154	15	.	.	PROPN
biomedich-684	154	16	,	,	PUNCT
biomedich-684	154	17	2024	2024	NUM
biomedich-684	154	18	)	)	PUNCT
biomedich-684	154	19	.	.	PUNCT
biomedich-684	155	1	toxicity	toxicity	NOUN
biomedich-684	155	2	the	the	DET
biomedich-684	155	3	toxicity	toxicity	NOUN
biomedich-684	155	4	level	level	NOUN
biomedich-684	155	5	of	of	ADP
biomedich-684	155	6	the	the	DET
biomedich-684	155	7	compound	compound	NOUN
biomedich-684	155	8	is	be	AUX
biomedich-684	155	9	predicted	predict	VERB
biomedich-684	155	10	by	by	ADP
biomedich-684	155	11	pkcsm	pkcsm	NOUN
biomedich-684	155	12	,	,	PUNCT
biomedich-684	155	13	with	with	ADP
biomedich-684	155	14	the	the	DET
biomedich-684	155	15	lethal	lethal	ADJ
biomedich-684	155	16	concentration	concentration	NOUN
biomedich-684	155	17	value	value	NOUN
biomedich-684	155	18	(	(	PUNCT
biomedich-684	155	19	ld50	ld50	PROPN
biomedich-684	155	20	)	)	PUNCT
biomedich-684	155	21	describing	describe	VERB
biomedich-684	155	22	the	the	DET
biomedich-684	155	23	amount	amount	NOUN
biomedich-684	155	24	of	of	ADP
biomedich-684	155	25	compound	compound	NOUN
biomedich-684	155	26	given	give	VERB
biomedich-684	155	27	that	that	PRON
biomedich-684	155	28	can	can	AUX
biomedich-684	155	29	cause	cause	VERB
biomedich-684	155	30	death	death	NOUN
biomedich-684	155	31	by	by	ADP
biomedich-684	155	32	50	50	NUM
biomedich-684	155	33	%	%	NOUN
biomedich-684	155	34	,	,	PUNCT
biomedich-684	155	35	which	which	PRON
biomedich-684	155	36	ranges	range	VERB
biomedich-684	155	37	from	from	ADP
biomedich-684	155	38	2,162	2,162	NUM
biomedich-684	155	39	to	to	ADP
biomedich-684	155	40	2,651	2,651	NUM
biomedich-684	155	41	mg	mg	PROPN
biomedich-684	155	42	/	/	SYM
biomedich-684	155	43	kg	kg	PROPN
biomedich-684	155	44	/	/	SYM
biomedich-684	155	45	day	day	NOUN
biomedich-684	155	46	.	.	PUNCT
biomedich-684	156	1	the	the	DET
biomedich-684	156	2	maximum	maximum	ADJ
biomedich-684	156	3	tolerated	tolerate	VERB
biomedich-684	156	4	dose	dose	PROPN
biomedich-684	156	5	(	(	PUNCT
biomedich-684	156	6	mtd	mtd	PROPN
biomedich-684	156	7	)	)	PUNCT
biomedich-684	156	8	is	be	AUX
biomedich-684	156	9	defined	define	VERB
biomedich-684	156	10	as	as	ADP
biomedich-684	156	11	the	the	DET
biomedich-684	156	12	toxic	toxic	ADJ
biomedich-684	156	13	dose	dose	NOUN
biomedich-684	156	14	threshold	threshold	NOUN
biomedich-684	156	15	of	of	ADP
biomedich-684	156	16	chemicals	chemical	NOUN
biomedich-684	156	17	in	in	ADP
biomedich-684	156	18	humans	human	NOUN
biomedich-684	156	19	.	.	PUNCT
biomedich-684	157	1	according	accord	VERB
biomedich-684	157	2	to	to	ADP
biomedich-684	157	3	the	the	DET
biomedich-684	157	4	pkcsm	pkcsm	NOUN
biomedich-684	157	5	,	,	PUNCT
biomedich-684	157	6	an	an	DET
biomedich-684	157	7	mtd	mtd	NOUN
biomedich-684	157	8	of	of	ADP
biomedich-684	157	9	less	less	ADJ
biomedich-684	157	10	than	than	ADP
biomedich-684	157	11	or	or	CCONJ
biomedich-684	157	12	equal	equal	ADJ
biomedich-684	157	13	to	to	ADP
biomedich-684	157	14	0.477	0.477	NUM
biomedich-684	157	15	log	log	NOUN
biomedich-684	157	16	(	(	PUNCT
biomedich-684	157	17	mg	mg	PROPN
biomedich-684	157	18	/	/	SYM
biomedich-684	157	19	kg	kg	PROPN
biomedich-684	157	20	/	/	SYM
biomedich-684	157	21	day	day	NOUN
biomedich-684	157	22	)	)	PUNCT
biomedich-684	157	23	is	be	AUX
biomedich-684	157	24	considered	consider	VERB
biomedich-684	157	25	low	low	ADJ
biomedich-684	157	26	toxicity	toxicity	NOUN
biomedich-684	157	27	,	,	PUNCT
biomedich-684	157	28	while	while	SCONJ
biomedich-684	157	29	an	an	DET
biomedich-684	157	30	mtd	mtd	NOUN
biomedich-684	157	31	exceeding	exceed	VERB
biomedich-684	157	32	0.477	0.477	NUM
biomedich-684	157	33	log	log	NOUN
biomedich-684	157	34	(	(	PUNCT
biomedich-684	157	35	mg	mg	PROPN
biomedich-684	157	36	/	/	SYM
biomedich-684	157	37	kg	kg	PROPN
biomedich-684	157	38	/	/	SYM
biomedich-684	157	39	day	day	NOUN
biomedich-684	157	40	)	)	PUNCT
biomedich-684	157	41	is	be	AUX
biomedich-684	157	42	classified	classify	VERB
biomedich-684	157	43	as	as	ADP
biomedich-684	157	44	high	high	ADJ
biomedich-684	157	45	toxicity	toxicity	NOUN
biomedich-684	157	46	(	(	PUNCT
biomedich-684	157	47	prasetiyo	prasetiyo	NOUN
biomedich-684	157	48	et	et	NOUN
biomedich-684	157	49	al	al	PROPN
biomedich-684	157	50	.	.	PROPN
biomedich-684	157	51	,	,	PUNCT
biomedich-684	157	52	2024	2024	NUM
biomedich-684	157	53	)	)	PUNCT
biomedich-684	157	54	.	.	PUNCT
biomedich-684	158	1	conclusions	conclusion	NOUN
biomedich-684	158	2	molecular	molecular	ADJ
biomedich-684	158	3	docking	docking	NOUN
biomedich-684	158	4	and	and	CCONJ
biomedich-684	158	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	158	6	studies	study	NOUN
biomedich-684	158	7	were	be	AUX
biomedich-684	158	8	carried	carry	VERB
biomedich-684	158	9	out	out	ADP
biomedich-684	158	10	on	on	ADP
biomedich-684	158	11	four	four	NUM
biomedich-684	158	12	bioactive	bioactive	ADJ
biomedich-684	158	13	compounds	compound	NOUN
biomedich-684	158	14	from	from	ADP
biomedich-684	158	15	the	the	DET
biomedich-684	158	16	stem	stem	NOUN
biomedich-684	158	17	bark	bark	NOUN
biomedich-684	158	18	of	of	ADP
biomedich-684	158	19	the	the	DET
biomedich-684	158	20	faloak	faloak	NOUN
biomedich-684	158	21	plant	plant	NOUN
biomedich-684	158	22	.	.	PUNCT
biomedich-684	159	1	this	this	DET
biomedich-684	159	2	study	study	NOUN
biomedich-684	159	3	confirmed	confirm	VERB
biomedich-684	159	4	that	that	SCONJ
biomedich-684	159	5	three	three	NUM
biomedich-684	159	6	bioactive	bioactive	ADJ
biomedich-684	159	7	compounds	compound	NOUN
biomedich-684	159	8	such	such	ADJ
biomedich-684	159	9	as	as	ADP
biomedich-684	159	10	beta	beta	NOUN
biomedich-684	159	11	-	-	PUNCT
biomedich-684	159	12	sitosterol	sitosterol	NOUN
biomedich-684	159	13	,	,	PUNCT
biomedich-684	159	14	catechin	catechin	NOUN
biomedich-684	159	15	and	and	CCONJ
biomedich-684	159	16	epicatechin	epicatechin	NOUN
biomedich-684	159	17	have	have	VERB
biomedich-684	159	18	antidiabetic	antidiabetic	ADJ
biomedich-684	159	19	activity	activity	NOUN
biomedich-684	159	20	as	as	ADP
biomedich-684	159	21	dpp	dpp	NOUN
biomedich-684	159	22	-	-	PUNCT
biomedich-684	159	23	iv	iv	NOUN
biomedich-684	159	24	receptor	receptor	NOUN
biomedich-684	159	25	blockers	blocker	NOUN
biomedich-684	159	26	.	.	PUNCT
biomedich-684	160	1	as	as	ADP
biomedich-684	160	2	a	a	DET
biomedich-684	160	3	result	result	NOUN
biomedich-684	160	4	of	of	ADP
biomedich-684	160	5	their	their	PRON
biomedich-684	160	6	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	160	7	profiles	profile	NOUN
biomedich-684	160	8	,	,	PUNCT
biomedich-684	160	9	these	these	DET
biomedich-684	160	10	bioactive	bioactive	ADJ
biomedich-684	160	11	compounds	compound	NOUN
biomedich-684	160	12	may	may	AUX
biomedich-684	160	13	have	have	VERB
biomedich-684	160	14	potential	potential	NOUN
biomedich-684	160	15	as	as	ADP
biomedich-684	160	16	drugs	drug	NOUN
biomedich-684	160	17	for	for	ADP
biomedich-684	160	18	the	the	DET
biomedich-684	160	19	treatment	treatment	NOUN
biomedich-684	160	20	of	of	ADP
biomedich-684	160	21	diabetes	diabetes	NOUN
biomedich-684	160	22	.	.	PUNCT
biomedich-684	161	1	184	184	NUM
biomedich-684	161	2	biology	biology	NOUN
biomedich-684	161	3	,	,	PUNCT
biomedich-684	161	4	medicine	medicine	NOUN
biomedich-684	161	5	,	,	PUNCT
biomedich-684	161	6	&	&	CCONJ
biomedich-684	161	7	natural	natural	ADJ
biomedich-684	161	8	product	product	NOUN
biomedich-684	161	9	chemistry	chemistry	NOUN
biomedich-684	161	10	14	14	NUM
biomedich-684	161	11	(	(	PUNCT
biomedich-684	161	12	1	1	NUM
biomedich-684	161	13	)	)	PUNCT
biomedich-684	161	14	,	,	PUNCT
biomedich-684	161	15	2025	2025	NUM
biomedich-684	161	16	:	:	PUNCT
biomedich-684	161	17	177	177	NUM
biomedich-684	161	18	-	-	SYM
biomedich-684	161	19	184	184	NUM
biomedich-684	161	20	acknowledgements	acknowledgement	NOUN
biomedich-684	161	21	:	:	PUNCT
biomedich-684	161	22	the	the	DET
biomedich-684	161	23	authors	author	NOUN
biomedich-684	161	24	would	would	AUX
biomedich-684	161	25	like	like	VERB
biomedich-684	161	26	to	to	PART
biomedich-684	161	27	thank	thank	VERB
biomedich-684	161	28	prof	prof	PROPN
biomedich-684	161	29	.	.	PUNCT
biomedich-684	162	1	dr	dr	PROPN
biomedich-684	162	2	.	.	PROPN
biomedich-684	162	3	apt	apt	PROPN
biomedich-684	162	4	.	.	PROPN
biomedich-684	162	5	siswandono	siswandono	PROPN
biomedich-684	162	6	,	,	PUNCT
biomedich-684	162	7	m.s	m.s	PROPN
biomedich-684	162	8	.	.	PROPN
biomedich-684	163	1	for	for	ADP
biomedich-684	163	2	permission	permission	NOUN
biomedich-684	163	3	to	to	PART
biomedich-684	163	4	use	use	VERB
biomedich-684	163	5	the	the	DET
biomedich-684	163	6	molegro	molegro	ADJ
biomedich-684	163	7	virtual	virtual	ADJ
biomedich-684	163	8	docker	docker	PROPN
biomedich-684	163	9	licence	licence	NOUN
biomedich-684	163	10	for	for	ADP
biomedich-684	163	11	this	this	DET
biomedich-684	163	12	research	research	NOUN
biomedich-684	163	13	.	.	PUNCT
biomedich-684	164	1	competing	compete	VERB
biomedich-684	164	2	interests	interest	NOUN
biomedich-684	164	3	:	:	PUNCT
biomedich-684	164	4	the	the	DET
biomedich-684	164	5	authors	author	NOUN
biomedich-684	164	6	declare	declare	VERB
biomedich-684	164	7	that	that	SCONJ
biomedich-684	164	8	there	there	PRON
biomedich-684	164	9	are	be	VERB
biomedich-684	164	10	no	no	DET
biomedich-684	164	11	competing	compete	VERB
biomedich-684	164	12	interests	interest	NOUN
biomedich-684	164	13	.	.	PUNCT
biomedich-684	165	1	references	reference	NOUN
biomedich-684	165	2	asyikin	asyikin	PROPN
biomedich-684	165	3	,	,	PUNCT
biomedich-684	165	4	a.	a.	PROPN
biomedich-684	165	5	,	,	PUNCT
biomedich-684	165	6	&	&	CCONJ
biomedich-684	165	7	ratnasari	ratnasari	PROPN
biomedich-684	165	8	dewi	dewi	PROPN
biomedich-684	165	9	poltekkes	poltekke	VERB
biomedich-684	165	10	kemenkes	kemenkes	PROPN
biomedich-684	165	11	makassar	makassar	PROPN
biomedich-684	165	12	(	(	PUNCT
biomedich-684	165	13	2024	2024	NUM
biomedich-684	165	14	)	)	PUNCT
biomedich-684	165	15	.	.	PUNCT
biomedich-684	166	1	healthy	healthy	ADJ
biomedich-684	166	2	living	live	VERB
biomedich-684	166	3	education	education	NOUN
biomedich-684	166	4	for	for	ADP
biomedich-684	166	5	diabetes	diabetes	NOUN
biomedich-684	166	6	prevention	prevention	NOUN
biomedich-684	166	7	by	by	ADP
biomedich-684	166	8	utilizing	utilize	VERB
biomedich-684	166	9	instant	instant	ADJ
biomedich-684	166	10	powder	powder	NOUN
biomedich-684	166	11	of	of	ADP
biomedich-684	166	12	sappan	sappan	NOUN
biomedich-684	166	13	w.	w.	PROPN
biomedich-684	166	14	jurnal	jurnal	PROPN
biomedich-684	166	15	pengabdian	pengabdian	PROPN
biomedich-684	166	16	kefarmasian	kefarmasian	PROPN
biomedich-684	166	17	,	,	PUNCT
biomedich-684	166	18	5(1	5(1	NUM
biomedich-684	166	19	)	)	PUNCT
biomedich-684	166	20	.	.	PUNCT
biomedich-684	167	1	https://doi.org/10.32382/jpk.v5i1.3447	https://doi.org/10.32382/jpk.v5i1.3447	PROPN
biomedich-684	167	2	fernandez	fernandez	PROPN
biomedich-684	167	3	,	,	PUNCT
biomedich-684	167	4	s.	s.	PROPN
biomedich-684	167	5	,	,	PUNCT
biomedich-684	167	6	&	&	CCONJ
biomedich-684	167	7	edel	edel	PROPN
biomedich-684	167	8	,	,	PUNCT
biomedich-684	167	9	e.	e.	PROPN
biomedich-684	167	10	(	(	PUNCT
biomedich-684	167	11	2017	2017	NUM
biomedich-684	167	12	)	)	PUNCT
biomedich-684	167	13	.	.	PUNCT
biomedich-684	168	1	pengaruh	pengaruh	PROPN
biomedich-684	168	2	pemberian	pemberian	PROPN
biomedich-684	168	3	ekstrak	ekstrak	PROPN
biomedich-684	168	4	etanol	etanol	PROPN
biomedich-684	168	5	kulit	kulit	PROPN
biomedich-684	168	6	batang	batang	PROPN
biomedich-684	168	7	faloak	faloak	PROPN
biomedich-684	168	8	(	(	PUNCT
biomedich-684	168	9	sterculia	sterculia	PROPN
biomedich-684	168	10	sp	sp	PROPN
biomedich-684	168	11	.	.	PUNCT
biomedich-684	168	12	)	)	PUNCT
biomedich-684	169	1	terhadap	terhadap	PROPN
biomedich-684	169	2	penurunan	penurunan	PROPN
biomedich-684	169	3	kadar	kadar	PROPN
biomedich-684	169	4	glukosa	glukosa	PROPN
biomedich-684	169	5	darah	darah	PROPN
biomedich-684	169	6	yang	yang	PROPN
biomedich-684	169	7	diinduksi	diinduksi	PROPN
biomedich-684	169	8	glukosa	glukosa	PROPN
biomedich-684	169	9	.	.	PUNCT
biomedich-684	170	1	jurnal	jurnal	ADJ
biomedich-684	170	2	info	info	NOUN
biomedich-684	170	3	kesehatan	kesehatan	PROPN
biomedich-684	170	4	,	,	PUNCT
biomedich-684	170	5	15(1	15(1	NUM
biomedich-684	170	6	)	)	PUNCT
biomedich-684	170	7	,	,	PUNCT
biomedich-684	170	8	129–136	129–136	NUM
biomedich-684	170	9	.	.	PUNCT
biomedich-684	171	1	kowalska	kowalska	PROPN
biomedich-684	171	2	,	,	PUNCT
biomedich-684	171	3	m.	m.	NOUN
biomedich-684	171	4	,	,	PUNCT
biomedich-684	171	5	fijałkowski	fijałkowski	NOUN
biomedich-684	171	6	,	,	PUNCT
biomedich-684	171	7	ł	ł	PROPN
biomedich-684	171	8	.	.	PROPN
biomedich-684	171	9	,	,	PUNCT
biomedich-684	171	10	&	&	CCONJ
biomedich-684	171	11	nowaczyk	nowaczyk	PROPN
biomedich-684	171	12	,	,	PUNCT
biomedich-684	171	13	a.	a.	NOUN
biomedich-684	171	14	(	(	PUNCT
biomedich-684	171	15	2018	2018	NUM
biomedich-684	171	16	)	)	PUNCT
biomedich-684	171	17	.	.	PUNCT
biomedich-684	172	1	the	the	DET
biomedich-684	172	2	biological	biological	ADJ
biomedich-684	172	3	activity	activity	NOUN
biomedich-684	172	4	assessment	assessment	NOUN
biomedich-684	172	5	of	of	ADP
biomedich-684	172	6	potential	potential	ADJ
biomedich-684	172	7	drugs	drug	NOUN
biomedich-684	172	8	acting	act	VERB
biomedich-684	172	9	on	on	ADP
biomedich-684	172	10	cardiovascular	cardiovascular	ADJ
biomedich-684	172	11	system	system	NOUN
biomedich-684	172	12	using	use	VERB
biomedich-684	172	13	lipinski	lipinski	PROPN
biomedich-684	172	14	and	and	CCONJ
biomedich-684	172	15	veber	veber	PROPN
biomedich-684	172	16	rules	rule	NOUN
biomedich-684	172	17	.	.	PUNCT
biomedich-684	173	1	journal	journal	NOUN
biomedich-684	173	2	of	of	ADP
biomedich-684	173	3	education	education	NOUN
biomedich-684	173	4	,	,	PUNCT
biomedich-684	173	5	8(12	8(12	NUM
biomedich-684	173	6	)	)	PUNCT
biomedich-684	173	7	,	,	PUNCT
biomedich-684	173	8	2391–8306	2391–8306	NUM
biomedich-684	173	9	.	.	PUNCT
biomedich-684	174	1	https://doi.org/10.5281/zenodo.2066519	https://doi.org/10.5281/zenodo.2066519	PROPN
biomedich-684	174	2	lipinski	lipinski	PROPN
biomedich-684	174	3	,	,	PUNCT
biomedich-684	174	4	c.	c.	PROPN
biomedich-684	174	5	a.	a.	PROPN
biomedich-684	174	6	,	,	PUNCT
biomedich-684	174	7	lombardo	lombardo	PROPN
biomedich-684	174	8	,	,	PUNCT
biomedich-684	174	9	f.	f.	PROPN
biomedich-684	174	10	,	,	PUNCT
biomedich-684	174	11	dominy	dominy	PROPN
biomedich-684	174	12	,	,	PUNCT
biomedich-684	174	13	b.	b.	PROPN
biomedich-684	174	14	w.	w.	PROPN
biomedich-684	174	15	,	,	PUNCT
biomedich-684	174	16	&	&	CCONJ
biomedich-684	174	17	feeney	feeney	PROPN
biomedich-684	174	18	,	,	PUNCT
biomedich-684	174	19	p.	p.	PROPN
biomedich-684	174	20	j.	j.	PROPN
biomedich-684	174	21	(	(	PUNCT
biomedich-684	174	22	2001	2001	NUM
biomedich-684	174	23	)	)	PUNCT
biomedich-684	174	24	.	.	PUNCT
biomedich-684	175	1	experimental	experimental	ADJ
biomedich-684	175	2	and	and	CCONJ
biomedich-684	175	3	computational	computational	ADJ
biomedich-684	175	4	approaches	approach	NOUN
biomedich-684	175	5	to	to	PART
biomedich-684	175	6	estimate	estimate	VERB
biomedich-684	175	7	solubility	solubility	NOUN
biomedich-684	175	8	and	and	CCONJ
biomedich-684	175	9	permeability	permeability	NOUN
biomedich-684	175	10	in	in	ADP
biomedich-684	175	11	drug	drug	NOUN
biomedich-684	175	12	discovery	discovery	NOUN
biomedich-684	175	13	and	and	CCONJ
biomedich-684	175	14	development	development	NOUN
biomedich-684	175	15	settings	setting	NOUN
biomedich-684	175	16	.	.	PUNCT
biomedich-684	176	1	advanced	advanced	ADJ
biomedich-684	176	2	drug	drug	NOUN
biomedich-684	176	3	delivery	delivery	NOUN
biomedich-684	176	4	reviews	review	NOUN
biomedich-684	176	5	,	,	PUNCT
biomedich-684	176	6	46(1	46(1	NUM
biomedich-684	176	7	–	–	PUNCT
biomedich-684	176	8	3	3	NUM
biomedich-684	176	9	)	)	PUNCT
biomedich-684	176	10	,	,	PUNCT
biomedich-684	176	11	3–26	3–26	NUM
biomedich-684	176	12	.	.	PUNCT
biomedich-684	177	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
biomedich-684	177	2	noolvi	noolvi	PROPN
biomedich-684	177	3	,	,	PUNCT
biomedich-684	177	4	m.	m.	NOUN
biomedich-684	177	5	n.	n.	PROPN
biomedich-684	177	6	,	,	PUNCT
biomedich-684	177	7	&	&	CCONJ
biomedich-684	177	8	patel	patel	PROPN
biomedich-684	177	9	,	,	PUNCT
biomedich-684	177	10	h.	h.	PROPN
biomedich-684	177	11	m.	m.	PROPN
biomedich-684	177	12	(	(	PUNCT
biomedich-684	177	13	2013	2013	NUM
biomedich-684	177	14	)	)	PUNCT
biomedich-684	177	15	.	.	PUNCT
biomedich-684	178	1	synthesis	synthesis	NOUN
biomedich-684	178	2	,	,	PUNCT
biomedich-684	178	3	method	method	NOUN
biomedich-684	178	4	optimization	optimization	NOUN
biomedich-684	178	5	,	,	PUNCT
biomedich-684	178	6	anticancer	anticancer	NOUN
biomedich-684	178	7	activity	activity	NOUN
biomedich-684	178	8	of	of	ADP
biomedich-684	178	9	2,3,7	2,3,7	NUM
biomedich-684	178	10	-	-	PUNCT
biomedich-684	178	11	trisubstituted	trisubstitute	VERB
biomedich-684	178	12	quinazoline	quinazoline	NOUN
biomedich-684	178	13	derivatives	derivative	NOUN
biomedich-684	178	14	and	and	CCONJ
biomedich-684	178	15	targeting	target	VERB
biomedich-684	178	16	egfr	egfr	ADJ
biomedich-684	178	17	-	-	PUNCT
biomedich-684	178	18	tyrosine	tyrosine	NOUN
biomedich-684	178	19	kinase	kinase	NOUN
biomedich-684	178	20	by	by	ADP
biomedich-684	178	21	rational	rational	ADJ
biomedich-684	178	22	approach	approach	NOUN
biomedich-684	178	23	.	.	PUNCT
biomedich-684	179	1	1st	1st	ADJ
biomedich-684	179	2	cancer	cancer	NOUN
biomedich-684	179	3	update	update	NOUN
biomedich-684	179	4	.	.	PUNCT
biomedich-684	180	1	arabian	arabian	ADJ
biomedich-684	180	2	journal	journal	PROPN
biomedich-684	180	3	of	of	ADP
biomedich-684	180	4	chemistry	chemistry	NOUN
biomedich-684	180	5	,	,	PUNCT
biomedich-684	180	6	6(1	6(1	NUM
biomedich-684	180	7	)	)	PUNCT
biomedich-684	180	8	,	,	PUNCT
biomedich-684	180	9	35–48	35–48	NUM
biomedich-684	180	10	.	.	PUNCT
biomedich-684	181	1	https://doi.org/10.1016/j.arabjc.2010.12.031	https://doi.org/10.1016/j.arabjc.2010.12.031	NUM
biomedich-684	181	2	octaviany	octaviany	NOUN
biomedich-684	181	3	,	,	PUNCT
biomedich-684	181	4	s.	s.	PROPN
biomedich-684	181	5	t.	t.	PROPN
biomedich-684	181	6	,	,	PUNCT
biomedich-684	181	7	&	&	CCONJ
biomedich-684	181	8	iskandar	iskandar	PROPN
biomedich-684	181	9	,	,	PUNCT
biomedich-684	181	10	y.	y.	PROPN
biomedich-684	181	11	(	(	PUNCT
biomedich-684	181	12	2023	2023	NUM
biomedich-684	181	13	)	)	PUNCT
biomedich-684	181	14	.	.	PUNCT
biomedich-684	182	1	review	review	NOUN
biomedich-684	182	2	artikel	artikel	PROPN
biomedich-684	182	3	:	:	PUNCT
biomedich-684	182	4	kandungan	kandungan	PROPN
biomedich-684	182	5	senyawa	senyawa	PROPN
biomedich-684	182	6	kimia	kimia	PROPN
biomedich-684	182	7	dan	dan	PROPN
biomedich-684	182	8	bioaktivitas	bioaktivitas	PROPN
biomedich-684	182	9	dari	dari	PROPN
biomedich-684	182	10	tanaman	tanaman	PROPN
biomedich-684	182	11	faloak	faloak	PROPN
biomedich-684	182	12	(	(	PUNCT
biomedich-684	182	13	sterculia	sterculia	PROPN
biomedich-684	182	14	quadrifida	quadrifida	PROPN
biomedich-684	182	15	)	)	PUNCT
biomedich-684	182	16	.	.	PUNCT
biomedich-684	183	1	jurnal	jurnal	ADJ
biomedich-684	183	2	farmasi	farmasi	PROPN
biomedich-684	183	3	sains	sains	PROPN
biomedich-684	183	4	dan	dan	PROPN
biomedich-684	183	5	terapan	terapan	PROPN
biomedich-684	183	6	,	,	PUNCT
biomedich-684	183	7	10(2	10(2	NUM
biomedich-684	183	8	)	)	PUNCT
biomedich-684	183	9	,	,	PUNCT
biomedich-684	183	10	72–78	72–78	NUM
biomedich-684	183	11	.	.	PUNCT
biomedich-684	183	12	https://doi.org/10.33508/jfst.v10i2.4754	https://doi.org/10.33508/jfst.v10i2.4754	PROPN
biomedich-684	183	13	prasetiyo	prasetiyo	PROPN
biomedich-684	183	14	,	,	PUNCT
biomedich-684	183	15	a.	a.	NOUN
biomedich-684	183	16	,	,	PUNCT
biomedich-684	183	17	martati	martati	PROPN
biomedich-684	183	18	,	,	PUNCT
biomedich-684	183	19	t.	t.	PROPN
biomedich-684	183	20	,	,	PUNCT
biomedich-684	183	21	&	&	CCONJ
biomedich-684	183	22	saputra	saputra	PROPN
biomedich-684	183	23	,	,	PUNCT
biomedich-684	183	24	p.	p.	PROPN
biomedich-684	183	25	w.	w.	PROPN
biomedich-684	183	26	(	(	PUNCT
biomedich-684	183	27	2024	2024	NUM
biomedich-684	183	28	)	)	PUNCT
biomedich-684	183	29	.	.	PUNCT
biomedich-684	184	1	in	in	ADP
biomedich-684	184	2	silico	silico	NOUN
biomedich-684	184	3	study	study	NOUN
biomedich-684	184	4	of	of	ADP
biomedich-684	184	5	bioactive	bioactive	ADJ
biomedich-684	184	6	compounds	compound	NOUN
biomedich-684	184	7	in	in	ADP
biomedich-684	184	8	herba	herba	PROPN
biomedich-684	184	9	sambiloto	sambiloto	PROPN
biomedich-684	184	10	(	(	PUNCT
biomedich-684	184	11	andrographis	andrographis	NOUN
biomedich-684	184	12	paniculata	paniculata	ADJ
biomedich-684	184	13	burm	burm	PROPN
biomedich-684	184	14	.	.	PUNCT
biomedich-684	184	15	f.	f.	PROPN
biomedich-684	184	16	nees	nees	PROPN
biomedich-684	184	17	)	)	PUNCT
biomedich-684	184	18	as	as	ADP
biomedich-684	184	19	hiv-1	hiv-1	PUNCT
biomedich-684	184	20	reverse	reverse	ADJ
biomedich-684	184	21	transcriptase	transcriptase	NOUN
biomedich-684	184	22	inhibitor	inhibitor	NOUN
biomedich-684	184	23	.	.	PUNCT
biomedich-684	185	1	in	in	ADP
biomedich-684	185	2	jurnal	jurnal	ADJ
biomedich-684	185	3	jamu	jamu	PROPN
biomedich-684	185	4	indonesia	indonesia	PROPN
biomedich-684	185	5	(	(	PUNCT
biomedich-684	185	6	vol	vol	NOUN
biomedich-684	185	7	.	.	NOUN
biomedich-684	185	8	9	9	NUM
biomedich-684	185	9	,	,	PUNCT
biomedich-684	185	10	issue	issue	NOUN
biomedich-684	185	11	2	2	NUM
biomedich-684	185	12	)	)	PUNCT
biomedich-684	185	13	.	.	PUNCT
biomedich-684	186	1	https://doi.org/10.29244/jji.v9i2.300	https://doi.org/10.29244/jji.v9i2.300	PROPN
biomedich-684	186	2	riwu	riwu	NOUN
biomedich-684	186	3	,	,	PUNCT
biomedich-684	186	4	a.	a.	NOUN
biomedich-684	186	5	g.	g.	PROPN
biomedich-684	186	6	,	,	PUNCT
biomedich-684	186	7	nugraha	nugraha	PROPN
biomedich-684	186	8	,	,	PUNCT
biomedich-684	186	9	j.	j.	PROPN
biomedich-684	186	10	,	,	PUNCT
biomedich-684	186	11	triyono	triyono	PROPN
biomedich-684	186	12	,	,	PUNCT
biomedich-684	186	13	e.	e.	PROPN
biomedich-684	186	14	a.	a.	PROPN
biomedich-684	186	15	,	,	PUNCT
biomedich-684	186	16	&	&	CCONJ
biomedich-684	186	17	purwanto	purwanto	PROPN
biomedich-684	186	18	,	,	PUNCT
biomedich-684	186	19	d.	d.	PROPN
biomedich-684	186	20	a.	a.	PROPN
biomedich-684	186	21	(	(	PUNCT
biomedich-684	186	22	2024	2024	NUM
biomedich-684	186	23	)	)	PUNCT
biomedich-684	186	24	.	.	PUNCT
biomedich-684	187	1	anti	anti	ADJ
biomedich-684	187	2	-	-	ADJ
biomedich-684	187	3	inflammatory	inflammatory	ADJ
biomedich-684	187	4	effect	effect	NOUN
biomedich-684	187	5	of	of	ADP
biomedich-684	187	6	faloak	faloak	NOUN
biomedich-684	187	7	(	(	PUNCT
biomedich-684	187	8	sterculia	sterculia	PROPN
biomedich-684	187	9	quadrifida	quadrifida	PROPN
biomedich-684	187	10	r.	r.	PROPN
biomedich-684	187	11	br	br	PROPN
biomedich-684	187	12	)	)	PUNCT
biomedich-684	187	13	stem	stem	NOUN
biomedich-684	187	14	bark	bark	NOUN
biomedich-684	187	15	on	on	ADP
biomedich-684	187	16	tnf	tnf	PROPN
biomedich-684	187	17	-	-	PUNCT
biomedich-684	187	18	α	α	PROPN
biomedich-684	187	19	,	,	PUNCT
biomedich-684	187	20	il-1β	il-1β	PROPN
biomedich-684	187	21	,	,	PUNCT
biomedich-684	187	22	and	and	CCONJ
biomedich-684	187	23	il-6	il-6	NOUN
biomedich-684	187	24	in	in	ADP
biomedich-684	187	25	denv-3	denv-3	PROPN
biomedich-684	187	26	-	-	PUNCT
biomedich-684	187	27	infected	infect	VERB
biomedich-684	187	28	wistar	wistar	PROPN
biomedich-684	187	29	rats	rat	NOUN
biomedich-684	187	30	.	.	PUNCT
biomedich-684	188	1	open	open	ADJ
biomedich-684	188	2	veterinary	veterinary	ADJ
biomedich-684	188	3	journal	journal	NOUN
biomedich-684	188	4	,	,	PUNCT
biomedich-684	188	5	14(4	14(4	NUM
biomedich-684	188	6	)	)	PUNCT
biomedich-684	188	7	,	,	PUNCT
biomedich-684	188	8	1043–1050	1043–1050	NUM
biomedich-684	188	9	.	.	PUNCT
biomedich-684	189	1	https://doi.org/10.5455/ovj.2024.v14.i4.11	https://doi.org/10.5455/ovj.2024.v14.i4.11	VERB
biomedich-684	189	2	santos	santos	PROPN
biomedich-684	189	3	,	,	PUNCT
biomedich-684	189	4	g.b	g.b	PROPN
biomedich-684	189	5	;	;	PUNCT
biomedich-684	189	6	ganesan	ganesan	PROPN
biomedich-684	189	7	,	,	PUNCT
biomedich-684	189	8	a	a	PRON
biomedich-684	189	9	;	;	PUNCT
biomedich-684	189	10	emery	emery	PROPN
biomedich-684	189	11	,	,	PUNCT
biomedich-684	189	12	f.	f.	PROPN
biomedich-684	189	13	s.	s.	PROPN
biomedich-684	189	14	(	(	PUNCT
biomedich-684	189	15	2016	2016	NUM
biomedich-684	189	16	)	)	PUNCT
biomedich-684	189	17	.	.	PUNCT
biomedich-684	190	1	oral	oral	ADJ
biomedich-684	190	2	administration	administration	NOUN
biomedich-684	190	3	of	of	ADP
biomedich-684	190	4	peptide	peptide	NOUN
biomedich-684	190	5	-	-	PUNCT
biomedich-684	190	6	based	base	VERB
biomedich-684	190	7	drugs	drug	NOUN
biomedich-684	190	8	:	:	PUNCT
biomedich-684	190	9	beyond	beyond	ADP
biomedich-684	190	10	lipinski	lipinski	PROPN
biomedich-684	190	11	’s	’s	PART
biomedich-684	190	12	rule	rule	NOUN
biomedich-684	190	13	.	.	PUNCT
biomedich-684	191	1	chemmedchem	chemmedchem	PROPN
biomedich-684	191	2	,	,	PUNCT
biomedich-684	191	3	11(20	11(20	NUM
biomedich-684	191	4	)	)	PUNCT
biomedich-684	191	5	,	,	PUNCT
biomedich-684	191	6	2245–2251	2245–2251	NUM
biomedich-684	191	7	.	.	PUNCT
biomedich-684	192	1	https://doi.org/10.1002/cmdc.201600288	https://doi.org/10.1002/cmdc.201600288	ADJ
biomedich-684	192	2	yeni	yeni	NOUN
biomedich-684	192	3	,	,	PUNCT
biomedich-684	192	4	y.	y.	PROPN
biomedich-684	192	5	,	,	PUNCT
biomedich-684	192	6	&	&	CCONJ
biomedich-684	192	7	rachmania	rachmania	PROPN
biomedich-684	192	8	,	,	PUNCT
biomedich-684	192	9	r.	r.	PROPN
biomedich-684	192	10	a.	a.	PROPN
biomedich-684	192	11	(	(	PUNCT
biomedich-684	192	12	2022	2022	NUM
biomedich-684	192	13	)	)	PUNCT
biomedich-684	192	14	.	.	PUNCT
biomedich-684	193	1	the	the	DET
biomedich-684	193	2	prediction	prediction	NOUN
biomedich-684	193	3	of	of	ADP
biomedich-684	193	4	pharmacokinetic	pharmacokinetic	ADJ
biomedich-684	193	5	properties	property	NOUN
biomedich-684	193	6	of	of	ADP
biomedich-684	193	7	compounds	compound	NOUN
biomedich-684	193	8	in	in	ADP
biomedich-684	193	9	hemigraphis	hemigraphis	PRON
biomedich-684	193	10	alternata	alternata	NOUN
biomedich-684	193	11	(	(	PUNCT
biomedich-684	193	12	burm.f	burm.f	NOUN
biomedich-684	193	13	.	.	PUNCT
biomedich-684	193	14	)	)	PUNCT
biomedich-684	194	1	t.	t.	NOUN
biomedich-684	194	2	ander	ander	NOUN
biomedich-684	194	3	leaves	leave	VERB
biomedich-684	194	4	using	use	VERB
biomedich-684	194	5	pkcsm	pkcsm	NOUN
biomedich-684	194	6	.	.	PUNCT
biomedich-684	195	1	indonesian	indonesian	ADJ
biomedich-684	195	2	journal	journal	PROPN
biomedich-684	195	3	of	of	ADP
biomedich-684	195	4	chemistry	chemistry	NOUN
biomedich-684	195	5	,	,	PUNCT
biomedich-684	195	6	22(4	22(4	NUM
biomedich-684	195	7	)	)	PUNCT
biomedich-684	195	8	,	,	PUNCT
biomedich-684	195	9	1081–1089	1081–1089	NUM
biomedich-684	195	10	.	.	PUNCT
biomedich-684	196	1	https://doi.org/10.22146/ijc.73117	https://doi.org/10.22146/ijc.73117	PROPN
biomedich-684	196	2	zubair	zubair	PROPN
biomedich-684	196	3	,	,	PUNCT
biomedich-684	196	4	m.	m.	PROPN
biomedich-684	196	5	s.	s.	PROPN
biomedich-684	196	6	,	,	PUNCT
biomedich-684	196	7	maulana	maulana	PROPN
biomedich-684	196	8	,	,	PUNCT
biomedich-684	196	9	s.	s.	PROPN
biomedich-684	196	10	,	,	PUNCT
biomedich-684	196	11	&	&	CCONJ
biomedich-684	196	12	mukaddas	mukaddas	PROPN
biomedich-684	196	13	,	,	PUNCT
biomedich-684	196	14	a.	a.	NOUN
biomedich-684	196	15	(	(	PUNCT
biomedich-684	196	16	2020	2020	NUM
biomedich-684	196	17	)	)	PUNCT
biomedich-684	196	18	.	.	PUNCT
biomedich-684	197	1	penambatan	penambatan	ADJ
biomedich-684	197	2	molekuler	molekuler	NOUN
biomedich-684	197	3	dan	dan	PROPN
biomedich-684	197	4	simulasi	simulasi	PROPN
biomedich-684	197	5	dinamika	dinamika	PROPN
biomedich-684	197	6	molekuler	molekuler	PROPN
biomedich-684	197	7	senyawa	senyawa	PROPN
biomedich-684	197	8	dari	dari	PROPN
biomedich-684	197	9	genus	genus	PROPN
biomedich-684	197	10	nigella	nigella	PROPN
biomedich-684	197	11	terhadap	terhadap	PROPN
biomedich-684	197	12	penghambatan	penghambatan	PROPN
biomedich-684	197	13	aktivitas	aktivita	VERB
biomedich-684	197	14	enzim	enzim	PROPN
biomedich-684	197	15	protease	protease	PROPN
biomedich-684	197	16	hiv-1	hiv-1	NOUN
biomedich-684	197	17	.	.	PUNCT
biomedich-684	198	1	jurnal	jurnal	PROPN
biomedich-684	198	2	farmasi	farmasi	PROPN
biomedich-684	198	3	galenika	galenika	PROPN
biomedich-684	198	4	(	(	PUNCT
biomedich-684	198	5	galenika	galenika	PROPN
biomedich-684	198	6	journal	journal	PROPN
biomedich-684	198	7	of	of	ADP
biomedich-684	198	8	pharmacy	pharmacy	NOUN
biomedich-684	198	9	)	)	PUNCT
biomedich-684	198	10	(	(	PUNCT
biomedich-684	198	11	e	e	NOUN
biomedich-684	198	12	-	-	NOUN
biomedich-684	198	13	journal	journal	NOUN
biomedich-684	198	14	)	)	PUNCT
biomedich-684	198	15	,	,	PUNCT
biomedich-684	198	16	6(1	6(1	NUM
biomedich-684	198	17	)	)	PUNCT
biomedich-684	198	18	,	,	PUNCT
biomedich-684	198	19	132–140	132–140	NUM
biomedich-684	198	20	.	.	PUNCT
biomedich-684	199	1	https://doi.org/10.22487/j24428744.2020.v6.i1.14982	https://doi.org/10.22487/j24428744.2020.v6.i1.14982	NOUN