id	sid	tid	token	lemma	pos
biomedich-710	1	1	biology	biology	NOUN
biomedich-710	1	2	,	,	PUNCT
biomedich-710	1	3	medicine	medicine	NOUN
biomedich-710	1	4	,	,	PUNCT
biomedich-710	1	5	&	&	CCONJ
biomedich-710	1	6	natural	natural	ADJ
biomedich-710	1	7	product	product	NOUN
biomedich-710	1	8	chemistry	chemistry	NOUN
biomedich-710	1	9	issn	issn	VERB
biomedich-710	1	10	2089	2089	NUM
biomedich-710	1	11	-	-	SYM
biomedich-710	1	12	6514	6514	NUM
biomedich-710	1	13	(	(	PUNCT
biomedich-710	1	14	paper	paper	NOUN
biomedich-710	1	15	)	)	PUNCT
biomedich-710	1	16	volume	volume	NOUN
biomedich-710	1	17	14	14	NUM
biomedich-710	1	18	,	,	PUNCT
biomedich-710	1	19	number	number	NOUN
biomedich-710	1	20	1	1	NUM
biomedich-710	1	21	,	,	PUNCT
biomedich-710	1	22	april	april	PROPN
biomedich-710	1	23	2025	2025	NUM
biomedich-710	1	24	|	|	ADV
biomedich-710	1	25	pages	page	NOUN
biomedich-710	1	26	:	:	PUNCT
biomedich-710	1	27	541	541	NUM
biomedich-710	1	28	-	-	SYM
biomedich-710	1	29	552	552	NUM
biomedich-710	1	30	|	|	ADV
biomedich-710	1	31	doi	doi	NOUN
biomedich-710	1	32	:	:	PUNCT
biomedich-710	1	33	10.14421	10.14421	NUM
biomedich-710	1	34	/	/	SYM
biomedich-710	1	35	biomedich.2025.141.541	biomedich.2025.141.541	PROPN
biomedich-710	1	36	-	-	PUNCT
biomedich-710	1	37	552	552	NUM
biomedich-710	1	38	issn	issn	PROPN
biomedich-710	1	39	2540	2540	NUM
biomedich-710	1	40	-	-	SYM
biomedich-710	1	41	9328	9328	NUM
biomedich-710	1	42	(	(	PUNCT
biomedich-710	1	43	online	online	ADJ
biomedich-710	1	44	)	)	PUNCT
biomedich-710	1	45	antimicrobial	antimicrobial	ADJ
biomedich-710	1	46	potential	potential	NOUN
biomedich-710	1	47	of	of	ADP
biomedich-710	1	48	phytochemicals	phytochemical	NOUN
biomedich-710	1	49	from	from	ADP
biomedich-710	1	50	coccinia	coccinia	NOUN
biomedich-710	1	51	grandis	grandis	PROPN
biomedich-710	1	52	leaves	leave	VERB
biomedich-710	1	53	:	:	PUNCT
biomedich-710	1	54	a	a	DET
biomedich-710	1	55	molecular	molecular	ADJ
biomedich-710	1	56	docking	docking	NOUN
biomedich-710	1	57	study	study	NOUN
biomedich-710	1	58	against	against	ADP
biomedich-710	1	59	penicillin	penicillin	NOUN
biomedich-710	1	60	-	-	PUNCT
biomedich-710	1	61	binding	bind	VERB
biomedich-710	1	62	protein	protein	NOUN
biomedich-710	1	63	5	5	NUM
biomedich-710	1	64	of	of	ADP
biomedich-710	1	65	escherichia	escherichia	NOUN
biomedich-710	1	66	coli	coli	NOUN
biomedich-710	1	67	and	and	CCONJ
biomedich-710	1	68	dna	dna	NOUN
biomedich-710	1	69	topoisomerase	topoisomerase	NOUN
biomedich-710	1	70	iv	iv	NUM
biomedich-710	1	71	subunit	subunit	NOUN
biomedich-710	1	72	b	b	PROPN
biomedich-710	1	73	(	(	PUNCT
biomedich-710	1	74	pare	pare	PROPN
biomedich-710	1	75	24kda	24kda	NOUN
biomedich-710	1	76	)	)	PUNCT
biomedich-710	1	77	of	of	ADP
biomedich-710	1	78	staphylococcus	staphylococcus	NOUN
biomedich-710	1	79	aureus	aureus	NOUN
biomedich-710	1	80	and	and	CCONJ
biomedich-710	1	81	escherichia	escherichia	NOUN
biomedich-710	1	82	coli	coli	NOUN
biomedich-710	1	83	malshan	malshan	NOUN
biomedich-710	1	84	isuranga	isuranga	NOUN
biomedich-710	1	85	*	*	PUNCT
biomedich-710	1	86	,	,	PUNCT
biomedich-710	1	87	dulki	dulki	VERB
biomedich-710	1	88	nihinsa	nihinsa	PROPN
biomedich-710	1	89	danthanarayana	danthanarayana	PROPN
biomedich-710	1	90	faculty	faculty	NOUN
biomedich-710	1	91	of	of	ADP
biomedich-710	1	92	science	science	NOUN
biomedich-710	1	93	,	,	PUNCT
biomedich-710	1	94	university	university	NOUN
biomedich-710	1	95	of	of	ADP
biomedich-710	1	96	kelaniya	kelaniya	PROPN
biomedich-710	1	97	,	,	PUNCT
biomedich-710	1	98	sri	sri	PROPN
biomedich-710	1	99	lanka	lanka	PROPN
biomedich-710	1	100	.	.	PUNCT
biomedich-710	2	1	corresponding	correspond	VERB
biomedich-710	2	2	author	author	NOUN
biomedich-710	2	3	*	*	PROPN
biomedich-710	2	4	malshanisuranga98@gmail.com	malshanisuranga98@gmail.com	NOUN
biomedich-710	2	5	manuscript	manuscript	NOUN
biomedich-710	2	6	received	receive	VERB
biomedich-710	2	7	:	:	PUNCT
biomedich-710	2	8	06	06	NUM
biomedich-710	2	9	february	february	PROPN
biomedich-710	2	10	,	,	PUNCT
biomedich-710	2	11	2025	2025	NUM
biomedich-710	2	12	.	.	PUNCT
biomedich-710	3	1	revision	revision	NOUN
biomedich-710	3	2	accepted	accept	VERB
biomedich-710	3	3	:	:	PUNCT
biomedich-710	3	4	20	20	NUM
biomedich-710	3	5	may	may	NOUN
biomedich-710	3	6	,	,	PUNCT
biomedich-710	3	7	2025	2025	NUM
biomedich-710	3	8	.	.	PUNCT
biomedich-710	4	1	published	publish	VERB
biomedich-710	4	2	:	:	PUNCT
biomedich-710	4	3	04	04	NUM
biomedich-710	4	4	august	august	PROPN
biomedich-710	4	5	,	,	PUNCT
biomedich-710	4	6	2025	2025	NUM
biomedich-710	4	7	.	.	PUNCT
biomedich-710	5	1	abstract	abstract	ADJ
biomedich-710	5	2	coccinia	coccinia	NOUN
biomedich-710	5	3	grandis	grandis	NOUN
biomedich-710	5	4	(	(	PUNCT
biomedich-710	5	5	c.	c.	PROPN
biomedich-710	5	6	grandis	grandis	PROPN
biomedich-710	5	7	)	)	PUNCT
biomedich-710	5	8	leaves	leave	NOUN
biomedich-710	5	9	,	,	PUNCT
biomedich-710	5	10	traditionally	traditionally	ADV
biomedich-710	5	11	used	use	VERB
biomedich-710	5	12	in	in	ADP
biomedich-710	5	13	sri	sri	PROPN
biomedich-710	5	14	lanka	lanka	PROPN
biomedich-710	5	15	for	for	ADP
biomedich-710	5	16	diabetes	diabetes	NOUN
biomedich-710	5	17	management	management	NOUN
biomedich-710	5	18	,	,	PUNCT
biomedich-710	5	19	also	also	ADV
biomedich-710	5	20	have	have	VERB
biomedich-710	5	21	a	a	DET
biomedich-710	5	22	potential	potential	ADJ
biomedich-710	5	23	antimicrobial	antimicrobial	ADJ
biomedich-710	5	24	activity	activity	NOUN
biomedich-710	5	25	.	.	PUNCT
biomedich-710	6	1	in	in	ADP
biomedich-710	6	2	this	this	DET
biomedich-710	6	3	study	study	NOUN
biomedich-710	6	4	,	,	PUNCT
biomedich-710	6	5	site	site	NOUN
biomedich-710	6	6	-	-	PUNCT
biomedich-710	6	7	specific	specific	ADJ
biomedich-710	6	8	molecular	molecular	ADJ
biomedich-710	6	9	docking	docking	NOUN
biomedich-710	6	10	was	be	AUX
biomedich-710	6	11	performed	perform	VERB
biomedich-710	6	12	to	to	PART
biomedich-710	6	13	investigate	investigate	VERB
biomedich-710	6	14	the	the	DET
biomedich-710	6	15	antimicrobial	antimicrobial	ADJ
biomedich-710	6	16	activity	activity	NOUN
biomedich-710	6	17	of	of	ADP
biomedich-710	6	18	phytochemicals	phytochemical	NOUN
biomedich-710	6	19	of	of	ADP
biomedich-710	6	20	coccinia	coccinia	NOUN
biomedich-710	6	21	grandis	grandis	PROPN
biomedich-710	6	22	leaves	leave	VERB
biomedich-710	6	23	against	against	ADP
biomedich-710	6	24	penicillin	penicillin	NOUN
biomedich-710	6	25	-	-	PUNCT
biomedich-710	6	26	binding	bind	VERB
biomedich-710	6	27	protein	protein	NOUN
biomedich-710	6	28	5	5	NUM
biomedich-710	6	29	(	(	PUNCT
biomedich-710	6	30	pbp	pbp	NOUN
biomedich-710	6	31	5	5	NUM
biomedich-710	6	32	)	)	PUNCT
biomedich-710	6	33	and	and	CCONJ
biomedich-710	6	34	dna	dna	PROPN
biomedich-710	6	35	topoisomerase	topoisomerase	NOUN
biomedich-710	6	36	iv	iv	NUM
biomedich-710	6	37	subunit	subunit	NOUN
biomedich-710	6	38	b	b	PROPN
biomedich-710	6	39	(	(	PUNCT
biomedich-710	6	40	pare	pare	PROPN
biomedich-710	6	41	24kda	24kda	NOUN
biomedich-710	6	42	)	)	PUNCT
biomedich-710	6	43	of	of	ADP
biomedich-710	6	44	escherichia	escherichia	NOUN
biomedich-710	6	45	coli	coli	NOUN
biomedich-710	6	46	(	(	PUNCT
biomedich-710	6	47	e.	e.	NOUN
biomedich-710	6	48	coli	coli	PROPN
biomedich-710	6	49	)	)	PUNCT
biomedich-710	6	50	and	and	CCONJ
biomedich-710	6	51	dna	dna	PROPN
biomedich-710	6	52	topoisomerase	topoisomerase	NOUN
biomedich-710	6	53	iv	iv	NUM
biomedich-710	6	54	subunit	subunit	NOUN
biomedich-710	6	55	b	b	PROPN
biomedich-710	6	56	(	(	PUNCT
biomedich-710	6	57	pare	pare	PROPN
biomedich-710	6	58	24kda	24kda	NOUN
biomedich-710	6	59	)	)	PUNCT
biomedich-710	6	60	of	of	ADP
biomedich-710	6	61	staphylococcus	staphylococcus	NOUN
biomedich-710	6	62	aureus	aureus	PROPN
biomedich-710	6	63	(	(	PUNCT
biomedich-710	6	64	s.	s.	PROPN
biomedich-710	6	65	aureus	aureus	PROPN
biomedich-710	6	66	)	)	PUNCT
biomedich-710	6	67	.	.	PUNCT
biomedich-710	7	1	penicillin	penicillin	NOUN
biomedich-710	7	2	was	be	AUX
biomedich-710	7	3	selected	select	VERB
biomedich-710	7	4	as	as	ADP
biomedich-710	7	5	the	the	DET
biomedich-710	7	6	reference	reference	NOUN
biomedich-710	7	7	molecule	molecule	NOUN
biomedich-710	7	8	for	for	ADP
biomedich-710	7	9	penicillin	penicillin	NOUN
biomedich-710	7	10	-	-	PUNCT
biomedich-710	7	11	binding	bind	VERB
biomedich-710	7	12	protein	protein	NOUN
biomedich-710	7	13	5	5	NUM
biomedich-710	7	14	and	and	CCONJ
biomedich-710	7	15	for	for	ADP
biomedich-710	7	16	dna	dna	NOUN
biomedich-710	7	17	topoisomerase	topoisomerase	NOUN
biomedich-710	7	18	iv	iv	NUM
biomedich-710	7	19	subunit	subunit	NOUN
biomedich-710	7	20	b	b	PROPN
biomedich-710	7	21	(	(	PUNCT
biomedich-710	7	22	pare	pare	PROPN
biomedich-710	7	23	24kda	24kda	NOUN
biomedich-710	7	24	)	)	PUNCT
biomedich-710	7	25	,	,	PUNCT
biomedich-710	7	26	novobiocin	novobiocin	PROPN
biomedich-710	7	27	was	be	AUX
biomedich-710	7	28	selected	select	VERB
biomedich-710	7	29	as	as	ADP
biomedich-710	7	30	the	the	DET
biomedich-710	7	31	reference	reference	NOUN
biomedich-710	7	32	molecule	molecule	NOUN
biomedich-710	7	33	.	.	PUNCT
biomedich-710	8	1	the	the	DET
biomedich-710	8	2	results	result	NOUN
biomedich-710	8	3	identified	identify	VERB
biomedich-710	8	4	lupeol	lupeol	NOUN
biomedich-710	8	5	(	(	PUNCT
biomedich-710	8	6	-7.72	-7.72	NOUN
biomedich-710	8	7	kcal	kcal	NOUN
biomedich-710	8	8	/	/	SYM
biomedich-710	8	9	mol	mol	NOUN
biomedich-710	8	10	)	)	PUNCT
biomedich-710	8	11	and	and	CCONJ
biomedich-710	8	12	beta	beta	NOUN
biomedich-710	8	13	-	-	PUNCT
biomedich-710	8	14	sitosterol	sitosterol	NOUN
biomedich-710	8	15	(	(	PUNCT
biomedich-710	8	16	-8.21kcal	-8.21kcal	ADJ
biomedich-710	8	17	/	/	SYM
biomedich-710	8	18	mol	mol	NOUN
biomedich-710	8	19	)	)	PUNCT
biomedich-710	8	20	have	have	VERB
biomedich-710	8	21	a	a	DET
biomedich-710	8	22	higher	high	ADJ
biomedich-710	8	23	binding	bind	VERB
biomedich-710	8	24	affinity	affinity	NOUN
biomedich-710	8	25	to	to	ADP
biomedich-710	8	26	pbp5	pbp5	PROPN
biomedich-710	8	27	of	of	ADP
biomedich-710	8	28	e.	e.	PROPN
biomedich-710	8	29	coli	coli	PROPN
biomedich-710	8	30	than	than	ADP
biomedich-710	8	31	penicillin	penicillin	NOUN
biomedich-710	8	32	(	(	PUNCT
biomedich-710	8	33	-7.20	-7.20	NUM
biomedich-710	8	34	kcal	kcal	NOUN
biomedich-710	8	35	/	/	SYM
biomedich-710	8	36	mol	mol	NOUN
biomedich-710	8	37	)	)	PUNCT
biomedich-710	8	38	.	.	PUNCT
biomedich-710	9	1	quercetin	quercetin	NOUN
biomedich-710	9	2	(	(	PUNCT
biomedich-710	9	3	-6.70	-6.70	PROPN
biomedich-710	9	4	kcal	kcal	NOUN
biomedich-710	9	5	/	/	SYM
biomedich-710	9	6	mol	mol	NOUN
biomedich-710	9	7	)	)	PUNCT
biomedich-710	9	8	,	,	PUNCT
biomedich-710	9	9	kaempferol	kaempferol	NOUN
biomedich-710	9	10	(	(	PUNCT
biomedich-710	9	11	-6.95	-6.95	NOUN
biomedich-710	9	12	kcal	kcal	PROPN
biomedich-710	9	13	/	/	SYM
biomedich-710	9	14	mol	mol	NOUN
biomedich-710	9	15	)	)	PUNCT
biomedich-710	9	16	,	,	PUNCT
biomedich-710	9	17	naringenin	naringenin	PROPN
biomedich-710	9	18	(	(	PUNCT
biomedich-710	9	19	-7.07	-7.07	NOUN
biomedich-710	9	20	kcal	kcal	PROPN
biomedich-710	9	21	/	/	SYM
biomedich-710	9	22	mol	mol	NOUN
biomedich-710	9	23	)	)	PUNCT
biomedich-710	9	24	,	,	PUNCT
biomedich-710	9	25	isoquercetin	isoquercetin	NOUN
biomedich-710	9	26	(	(	PUNCT
biomedich-710	9	27	-6.15	-6.15	NOUN
biomedich-710	9	28	kcal	kcal	NOUN
biomedich-710	9	29	/	/	SYM
biomedich-710	9	30	mol	mol	NOUN
biomedich-710	9	31	)	)	PUNCT
biomedich-710	9	32	,	,	PUNCT
biomedich-710	9	33	lupeol	lupeol	NOUN
biomedich-710	9	34	(	(	PUNCT
biomedich-710	9	35	-7.87	-7.87	NUM
biomedich-710	9	36	kcal	kcal	NOUN
biomedich-710	9	37	/	/	SYM
biomedich-710	9	38	mol	mol	NOUN
biomedich-710	9	39	)	)	PUNCT
biomedich-710	9	40	,	,	PUNCT
biomedich-710	9	41	beta	beta	NOUN
biomedich-710	9	42	-	-	PUNCT
biomedich-710	9	43	sitosterol	sitosterol	NOUN
biomedich-710	9	44	(	(	PUNCT
biomedich-710	9	45	-9.42	-9.42	ADP
biomedich-710	9	46	kcal	kcal	PROPN
biomedich-710	9	47	/	/	SYM
biomedich-710	9	48	mol	mol	NOUN
biomedich-710	9	49	)	)	PUNCT
biomedich-710	9	50	and	and	CCONJ
biomedich-710	9	51	sanguinarine	sanguinarine	NOUN
biomedich-710	9	52	(	(	PUNCT
biomedich-710	9	53	-9.07	-9.07	NOUN
biomedich-710	9	54	kcal	kcal	PROPN
biomedich-710	9	55	/	/	SYM
biomedich-710	9	56	mol	mol	NOUN
biomedich-710	9	57	)	)	PUNCT
biomedich-710	9	58	show	show	VERB
biomedich-710	9	59	higher	high	ADJ
biomedich-710	9	60	binding	bind	VERB
biomedich-710	9	61	affinity	affinity	NOUN
biomedich-710	9	62	to	to	PART
biomedich-710	9	63	dna	dna	VERB
biomedich-710	9	64	topoisomerase	topoisomerase	VERB
biomedich-710	9	65	iv	iv	NUM
biomedich-710	9	66	subunit	subunit	NOUN
biomedich-710	9	67	b	b	PROPN
biomedich-710	9	68	(	(	PUNCT
biomedich-710	9	69	pare	pare	PROPN
biomedich-710	9	70	24kda	24kda	NOUN
biomedich-710	9	71	)	)	PUNCT
biomedich-710	9	72	of	of	ADP
biomedich-710	9	73	s.	s.	PROPN
biomedich-710	9	74	aureus	aureus	PROPN
biomedich-710	9	75	than	than	ADP
biomedich-710	9	76	novobiocin	novobiocin	NOUN
biomedich-710	9	77	(	(	PUNCT
biomedich-710	9	78	-6.04	-6.04	NOUN
biomedich-710	9	79	kcal	kcal	NOUN
biomedich-710	9	80	/	/	SYM
biomedich-710	9	81	mol	mol	NOUN
biomedich-710	9	82	)	)	PUNCT
biomedich-710	9	83	.	.	PUNCT
biomedich-710	10	1	as	as	ADV
biomedich-710	10	2	well	well	ADV
biomedich-710	10	3	quercetin	quercetin	NOUN
biomedich-710	10	4	(	(	PUNCT
biomedich-710	10	5	6.85	6.85	NUM
biomedich-710	10	6	kcal	kcal	NOUN
biomedich-710	10	7	/	/	SYM
biomedich-710	10	8	mol	mol	NOUN
biomedich-710	10	9	)	)	PUNCT
biomedich-710	10	10	,	,	PUNCT
biomedich-710	10	11	kaempferol	kaempferol	NOUN
biomedich-710	10	12	(	(	PUNCT
biomedich-710	10	13	-6.82	-6.82	NOUN
biomedich-710	10	14	kcal	kcal	PROPN
biomedich-710	10	15	/	/	SYM
biomedich-710	10	16	mol	mol	NOUN
biomedich-710	10	17	)	)	PUNCT
biomedich-710	10	18	,	,	PUNCT
biomedich-710	10	19	naringenin	naringenin	PROPN
biomedich-710	10	20	(	(	PUNCT
biomedich-710	10	21	-7.23	-7.23	PROPN
biomedich-710	10	22	kcal	kcal	PROPN
biomedich-710	10	23	/	/	SYM
biomedich-710	10	24	mol	mol	NOUN
biomedich-710	10	25	)	)	PUNCT
biomedich-710	10	26	,	,	PUNCT
biomedich-710	10	27	isoquercetin	isoquercetin	NOUN
biomedich-710	10	28	(	(	PUNCT
biomedich-710	10	29	-6.20	-6.20	NUM
biomedich-710	10	30	kcal	kcal	PROPN
biomedich-710	10	31	/	/	SYM
biomedich-710	10	32	mol	mol	NOUN
biomedich-710	10	33	)	)	PUNCT
biomedich-710	10	34	,	,	PUNCT
biomedich-710	10	35	lupeol	lupeol	NOUN
biomedich-710	10	36	(	(	PUNCT
biomedich-710	10	37	-7.67	-7.67	NOUN
biomedich-710	10	38	kcal	kcal	NOUN
biomedich-710	10	39	/	/	SYM
biomedich-710	10	40	mol	mol	NOUN
biomedich-710	10	41	)	)	PUNCT
biomedich-710	10	42	,	,	PUNCT
biomedich-710	10	43	betasitosterol	betasitosterol	NOUN
biomedich-710	10	44	(	(	PUNCT
biomedich-710	10	45	-9.08	-9.08	NUM
biomedich-710	10	46	kcal	kcal	NOUN
biomedich-710	10	47	/	/	SYM
biomedich-710	10	48	mol	mol	NOUN
biomedich-710	10	49	)	)	PUNCT
biomedich-710	10	50	and	and	CCONJ
biomedich-710	10	51	sanguinarine	sanguinarine	NOUN
biomedich-710	10	52	(	(	PUNCT
biomedich-710	10	53	-9.03	-9.03	NOUN
biomedich-710	10	54	kcal	kcal	NOUN
biomedich-710	10	55	/	/	SYM
biomedich-710	10	56	mol	mol	NOUN
biomedich-710	10	57	)	)	PUNCT
biomedich-710	10	58	show	show	VERB
biomedich-710	10	59	higher	high	ADJ
biomedich-710	10	60	binding	bind	VERB
biomedich-710	10	61	affinity	affinity	NOUN
biomedich-710	10	62	to	to	PART
biomedich-710	10	63	dna	dna	VERB
biomedich-710	10	64	topoisomerase	topoisomerase	VERB
biomedich-710	10	65	iv	iv	NUM
biomedich-710	10	66	subunit	subunit	NOUN
biomedich-710	10	67	b	b	PROPN
biomedich-710	10	68	(	(	PUNCT
biomedich-710	10	69	pare	pare	PROPN
biomedich-710	10	70	24kda	24kda	NOUN
biomedich-710	10	71	)	)	PUNCT
biomedich-710	10	72	of	of	ADP
biomedich-710	10	73	e.	e.	PROPN
biomedich-710	10	74	coli	coli	NOUN
biomedich-710	10	75	than	than	ADP
biomedich-710	10	76	novobiocin	novobiocin	NOUN
biomedich-710	10	77	(	(	PUNCT
biomedich-710	10	78	-5.76	-5.76	PROPN
biomedich-710	10	79	kcal	kcal	PROPN
biomedich-710	10	80	/	/	SYM
biomedich-710	10	81	mol	mol	NOUN
biomedich-710	10	82	)	)	PUNCT
biomedich-710	10	83	.	.	PUNCT
biomedich-710	11	1	in	in	ADP
biomedich-710	11	2	silico	silico	NOUN
biomedich-710	11	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	11	4	and	and	CCONJ
biomedich-710	11	5	physicochemical	physicochemical	ADJ
biomedich-710	11	6	parameter	parameter	NOUN
biomedich-710	11	7	predictions	prediction	NOUN
biomedich-710	11	8	were	be	AUX
biomedich-710	11	9	also	also	ADV
biomedich-710	11	10	conducted	conduct	VERB
biomedich-710	11	11	to	to	PART
biomedich-710	11	12	study	study	VERB
biomedich-710	11	13	drug	drug	NOUN
biomedich-710	11	14	-	-	PUNCT
biomedich-710	11	15	likeness	likeness	NOUN
biomedich-710	11	16	of	of	ADP
biomedich-710	11	17	above	above	ADJ
biomedich-710	11	18	molecules	molecule	NOUN
biomedich-710	11	19	using	use	VERB
biomedich-710	11	20	specialized	specialized	ADJ
biomedich-710	11	21	web	web	NOUN
biomedich-710	11	22	servers	server	NOUN
biomedich-710	11	23	.	.	PUNCT
biomedich-710	12	1	keywords	keyword	NOUN
biomedich-710	12	2	:	:	PUNCT
biomedich-710	12	3	coccinia	coccinia	PROPN
biomedich-710	12	4	grandis	grandis	PROPN
biomedich-710	12	5	;	;	PUNCT
biomedich-710	12	6	escherichia	escherichia	NOUN
biomedich-710	12	7	coli	coli	NOUN
biomedich-710	12	8	;	;	PUNCT
biomedich-710	12	9	staphylococcus	staphylococcus	NOUN
biomedich-710	12	10	aureus	aureus	NOUN
biomedich-710	12	11	;	;	PUNCT
biomedich-710	12	12	penicillin	penicillin	NOUN
biomedich-710	12	13	-	-	PUNCT
biomedich-710	12	14	binding	bind	VERB
biomedich-710	12	15	protein	protein	NOUN
biomedich-710	12	16	5	5	NUM
biomedich-710	12	17	;	;	PUNCT
biomedich-710	12	18	dna	dna	PROPN
biomedich-710	12	19	topoisomerase	topoisomerase	NOUN
biomedich-710	12	20	iv	iv	NUM
biomedich-710	12	21	subunit	subunit	NOUN
biomedich-710	12	22	b	b	PROPN
biomedich-710	12	23	(	(	PUNCT
biomedich-710	12	24	pare	pare	PROPN
biomedich-710	12	25	24kda	24kda	NOUN
biomedich-710	12	26	)	)	PUNCT
biomedich-710	12	27	;	;	PUNCT
biomedich-710	12	28	molecular	molecular	ADJ
biomedich-710	12	29	docking	docking	NOUN
biomedich-710	12	30	.	.	PUNCT
biomedich-710	13	1	introduction	introduction	NOUN
biomedich-710	13	2	antibiotics	antibiotic	NOUN
biomedich-710	13	3	are	be	AUX
biomedich-710	13	4	the	the	DET
biomedich-710	13	5	most	most	ADV
biomedich-710	13	6	wonderful	wonderful	ADJ
biomedich-710	13	7	innovation	innovation	NOUN
biomedich-710	13	8	in	in	ADP
biomedich-710	13	9	the	the	DET
biomedich-710	13	10	history	history	NOUN
biomedich-710	13	11	of	of	ADP
biomedich-710	13	12	medicine	medicine	NOUN
biomedich-710	13	13	.	.	PUNCT
biomedich-710	14	1	from	from	ADP
biomedich-710	14	2	the	the	DET
biomedich-710	14	3	first	first	ADJ
biomedich-710	14	4	antibiotic	antibiotic	NOUN
biomedich-710	14	5	,	,	PUNCT
biomedich-710	14	6	penicillin	penicillin	NOUN
biomedich-710	14	7	,	,	PUNCT
biomedich-710	14	8	discovered	discover	VERB
biomedich-710	14	9	by	by	ADP
biomedich-710	14	10	alexander	alexander	PROPN
biomedich-710	14	11	fleming	fleming	PROPN
biomedich-710	14	12	in	in	ADP
biomedich-710	14	13	1928	1928	NUM
biomedich-710	14	14	,	,	PUNCT
biomedich-710	14	15	antibiotics	antibiotic	NOUN
biomedich-710	14	16	have	have	VERB
biomedich-710	14	17	a	a	DET
biomedich-710	14	18	long	long	ADJ
biomedich-710	14	19	development	development	NOUN
biomedich-710	14	20	history	history	NOUN
biomedich-710	14	21	.	.	PUNCT
biomedich-710	15	1	these	these	DET
biomedich-710	15	2	drugs	drug	NOUN
biomedich-710	15	3	have	have	AUX
biomedich-710	15	4	saved	save	VERB
biomedich-710	15	5	numerous	numerous	ADJ
biomedich-710	15	6	numbers	number	NOUN
biomedich-710	15	7	of	of	ADP
biomedich-710	15	8	lives	life	NOUN
biomedich-710	15	9	worldwide	worldwide	ADV
biomedich-710	15	10	.	.	PUNCT
biomedich-710	16	1	some	some	DET
biomedich-710	16	2	antibiotics	antibiotic	NOUN
biomedich-710	16	3	kill	kill	VERB
biomedich-710	16	4	the	the	DET
biomedich-710	16	5	microorganisms	microorganism	NOUN
biomedich-710	16	6	while	while	SCONJ
biomedich-710	16	7	others	other	NOUN
biomedich-710	16	8	reduce	reduce	VERB
biomedich-710	16	9	their	their	PRON
biomedich-710	16	10	growth	growth	NOUN
biomedich-710	16	11	rate	rate	NOUN
biomedich-710	16	12	.	.	PUNCT
biomedich-710	17	1	antibiotic	antibiotic	ADJ
biomedich-710	17	2	resistance	resistance	NOUN
biomedich-710	17	3	(	(	PUNCT
biomedich-710	17	4	abr	abr	PROPN
biomedich-710	17	5	)	)	PUNCT
biomedich-710	17	6	is	be	AUX
biomedich-710	17	7	the	the	DET
biomedich-710	17	8	ability	ability	NOUN
biomedich-710	17	9	of	of	ADP
biomedich-710	17	10	microorganisms	microorganism	NOUN
biomedich-710	17	11	to	to	PART
biomedich-710	17	12	withstand	withstand	VERB
biomedich-710	17	13	the	the	DET
biomedich-710	17	14	activity	activity	NOUN
biomedich-710	17	15	of	of	ADP
biomedich-710	17	16	the	the	DET
biomedich-710	17	17	antibiotic	antibiotic	NOUN
biomedich-710	17	18	.	.	PUNCT
biomedich-710	18	1	mutations	mutation	NOUN
biomedich-710	18	2	,	,	PUNCT
biomedich-710	18	3	horizontal	horizontal	ADJ
biomedich-710	18	4	gene	gene	NOUN
biomedich-710	18	5	transfer	transfer	NOUN
biomedich-710	18	6	,	,	PUNCT
biomedich-710	18	7	and	and	CCONJ
biomedich-710	18	8	human	human	ADJ
biomedich-710	18	9	actions	action	NOUN
biomedich-710	18	10	such	such	ADJ
biomedich-710	18	11	as	as	ADP
biomedich-710	18	12	misuse	misuse	NOUN
biomedich-710	18	13	of	of	ADP
biomedich-710	18	14	antibiotics	antibiotic	NOUN
biomedich-710	18	15	contribute	contribute	VERB
biomedich-710	18	16	to	to	ADP
biomedich-710	18	17	the	the	DET
biomedich-710	18	18	abr	abr	NOUN
biomedich-710	18	19	(	(	PUNCT
biomedich-710	18	20	larsson	larsson	PROPN
biomedich-710	18	21	&	&	CCONJ
biomedich-710	18	22	flach	flach	PROPN
biomedich-710	18	23	,	,	PUNCT
biomedich-710	18	24	2022	2022	NUM
biomedich-710	18	25	)	)	PUNCT
biomedich-710	18	26	.	.	PUNCT
biomedich-710	19	1	according	accord	VERB
biomedich-710	19	2	to	to	ADP
biomedich-710	19	3	the	the	DET
biomedich-710	19	4	world	world	PROPN
biomedich-710	19	5	health	health	NOUN
biomedich-710	19	6	organization	organization	NOUN
biomedich-710	19	7	(	(	PUNCT
biomedich-710	19	8	who	who	PRON
biomedich-710	19	9	)	)	PUNCT
biomedich-710	19	10	,	,	PUNCT
biomedich-710	19	11	abr	abr	VERB
biomedich-710	19	12	is	be	AUX
biomedich-710	19	13	one	one	NUM
biomedich-710	19	14	of	of	ADP
biomedich-710	19	15	the	the	DET
biomedich-710	19	16	most	most	ADV
biomedich-710	19	17	significant	significant	ADJ
biomedich-710	19	18	global	global	ADJ
biomedich-710	19	19	health	health	NOUN
biomedich-710	19	20	threats	threat	NOUN
biomedich-710	19	21	(	(	PUNCT
biomedich-710	19	22	global	global	ADJ
biomedich-710	19	23	antimicrobial	antimicrobial	ADJ
biomedich-710	19	24	resistance	resistance	NOUN
biomedich-710	19	25	and	and	CCONJ
biomedich-710	19	26	use	use	VERB
biomedich-710	19	27	surveillance	surveillance	NOUN
biomedich-710	19	28	system	system	NOUN
biomedich-710	19	29	(	(	PUNCT
biomedich-710	19	30	glass	glass	NOUN
biomedich-710	19	31	)	)	PUNCT
biomedich-710	19	32	report	report	NOUN
biomedich-710	19	33	2022	2022	NUM
biomedich-710	19	34	,	,	PUNCT
biomedich-710	19	35	2022	2022	NUM
biomedich-710	19	36	)	)	PUNCT
biomedich-710	19	37	.	.	PUNCT
biomedich-710	20	1	coccinia	coccinia	PROPN
biomedich-710	20	2	grandis	grandis	PROPN
biomedich-710	20	3	belongs	belong	VERB
biomedich-710	20	4	to	to	ADP
biomedich-710	20	5	the	the	DET
biomedich-710	20	6	family	family	NOUN
biomedich-710	20	7	cucurbitaceae	cucurbitaceae	NOUN
biomedich-710	20	8	,	,	PUNCT
biomedich-710	20	9	predominantly	predominantly	ADV
biomedich-710	20	10	distributed	distribute	VERB
biomedich-710	20	11	in	in	ADP
biomedich-710	20	12	tropical	tropical	ADJ
biomedich-710	20	13	asia	asia	PROPN
biomedich-710	20	14	and	and	CCONJ
biomedich-710	20	15	africa	africa	PROPN
biomedich-710	20	16	including	include	VERB
biomedich-710	20	17	pakistan	pakistan	PROPN
biomedich-710	20	18	,	,	PUNCT
biomedich-710	20	19	india	india	PROPN
biomedich-710	20	20	,	,	PUNCT
biomedich-710	20	21	and	and	CCONJ
biomedich-710	20	22	sri	sri	PROPN
biomedich-710	20	23	lanka	lanka	PROPN
biomedich-710	20	24	(	(	PUNCT
biomedich-710	20	25	farrukh	farrukh	PROPN
biomedich-710	20	26	et	et	PROPN
biomedich-710	20	27	al	al	PROPN
biomedich-710	20	28	.	.	PROPN
biomedich-710	20	29	,	,	PUNCT
biomedich-710	20	30	2008	2008	NUM
biomedich-710	20	31	)	)	PUNCT
biomedich-710	20	32	.	.	PUNCT
biomedich-710	21	1	c.	c.	PROPN
biomedich-710	21	2	grandis	grandis	PROPN
biomedich-710	21	3	is	be	AUX
biomedich-710	21	4	commonly	commonly	ADV
biomedich-710	21	5	known	know	VERB
biomedich-710	21	6	as	as	ADP
biomedich-710	21	7	ivy	ivy	PROPN
biomedich-710	21	8	gourd	gourd	NOUN
biomedich-710	21	9	or	or	CCONJ
biomedich-710	21	10	scarlet	scarlet	ADJ
biomedich-710	21	11	gourd	gourd	NOUN
biomedich-710	21	12	in	in	ADP
biomedich-710	21	13	english	english	PROPN
biomedich-710	21	14	;	;	PUNCT
biomedich-710	21	15	kowakka	kowakka	VERB
biomedich-710	21	16	in	in	ADP
biomedich-710	21	17	sinhala	sinhala	PROPN
biomedich-710	21	18	.	.	PUNCT
biomedich-710	22	1	in	in	ADP
biomedich-710	22	2	sri	sri	PROPN
biomedich-710	22	3	lanka	lanka	PROPN
biomedich-710	22	4	,	,	PUNCT
biomedich-710	22	5	this	this	DET
biomedich-710	22	6	plant	plant	NOUN
biomedich-710	22	7	is	be	AUX
biomedich-710	22	8	predominantly	predominantly	ADV
biomedich-710	22	9	distributed	distribute	VERB
biomedich-710	22	10	in	in	ADP
biomedich-710	22	11	the	the	DET
biomedich-710	22	12	north	north	NOUN
biomedich-710	22	13	central	central	ADJ
biomedich-710	22	14	,	,	PUNCT
biomedich-710	22	15	southern	southern	ADJ
biomedich-710	22	16	,	,	PUNCT
biomedich-710	22	17	and	and	CCONJ
biomedich-710	22	18	western	western	ADJ
biomedich-710	22	19	regions	region	NOUN
biomedich-710	22	20	.	.	PUNCT
biomedich-710	23	1	from	from	ADP
biomedich-710	23	2	centuries	century	NOUN
biomedich-710	23	3	local	local	ADJ
biomedich-710	23	4	population	population	NOUN
biomedich-710	23	5	of	of	ADP
biomedich-710	23	6	sri	sri	PROPN
biomedich-710	23	7	lanka	lanka	PROPN
biomedich-710	23	8	used	use	VERB
biomedich-710	23	9	leaves	leave	NOUN
biomedich-710	23	10	of	of	ADP
biomedich-710	23	11	this	this	DET
biomedich-710	23	12	plant	plant	NOUN
biomedich-710	23	13	for	for	ADP
biomedich-710	23	14	diabetes	diabetes	NOUN
biomedich-710	23	15	management	management	NOUN
biomedich-710	23	16	(	(	PUNCT
biomedich-710	23	17	attanayake	attanayake	NOUN
biomedich-710	23	18	et	et	PROPN
biomedich-710	23	19	al	al	PROPN
biomedich-710	23	20	.	.	PROPN
biomedich-710	23	21	,2016	,2016	PUNCT
biomedich-710	23	22	)	)	PUNCT
biomedich-710	23	23	.	.	PUNCT
biomedich-710	24	1	researchers	researcher	NOUN
biomedich-710	24	2	suggest	suggest	VERB
biomedich-710	24	3	that	that	SCONJ
biomedich-710	24	4	leaf	leaf	NOUN
biomedich-710	24	5	extract	extract	NOUN
biomedich-710	24	6	of	of	ADP
biomedich-710	24	7	c.	c.	PROPN
biomedich-710	24	8	grandis	grandis	PROPN
biomedich-710	24	9	exhibits	exhibit	VERB
biomedich-710	24	10	anti	anti	ADJ
biomedich-710	24	11	-	-	ADJ
biomedich-710	24	12	hyperglycemic	hyperglycemic	ADJ
biomedich-710	24	13	,	,	PUNCT
biomedich-710	24	14	xanthine	xanthine	NOUN
biomedich-710	24	15	oxidase	oxidase	NOUN
biomedich-710	24	16	inhibitory	inhibitory	NOUN
biomedich-710	24	17	,	,	PUNCT
biomedich-710	24	18	analgesic	analgesic	ADJ
biomedich-710	24	19	,	,	PUNCT
biomedich-710	24	20	antiinflammatory	antiinflammatory	NOUN
biomedich-710	24	21	,	,	PUNCT
biomedich-710	24	22	antipyretic	antipyretic	ADJ
biomedich-710	24	23	,	,	PUNCT
biomedich-710	24	24	antioxidant	antioxidant	ADJ
biomedich-710	24	25	,	,	PUNCT
biomedich-710	24	26	antihyperlipidemic	antihyperlipidemic	ADJ
biomedich-710	24	27	,	,	PUNCT
biomedich-710	24	28	antimicrobial	antimicrobial	ADJ
biomedich-710	24	29	,	,	PUNCT
biomedich-710	24	30	and	and	CCONJ
biomedich-710	24	31	anti	anti	ADJ
biomedich-710	24	32	-	-	ADJ
biomedich-710	24	33	hepatotoxic	hepatotoxic	ADJ
biomedich-710	24	34	activities	activity	NOUN
biomedich-710	24	35	(	(	PUNCT
biomedich-710	24	36	ramachandran	ramachandran	PROPN
biomedich-710	24	37	et	et	PROPN
biomedich-710	24	38	al	al	PROPN
biomedich-710	24	39	.	.	PROPN
biomedich-710	24	40	,	,	PUNCT
biomedich-710	24	41	2014	2014	NUM
biomedich-710	24	42	)	)	PUNCT
biomedich-710	24	43	.	.	PUNCT
biomedich-710	25	1	penicillin	penicillin	NOUN
biomedich-710	25	2	-	-	PUNCT
biomedich-710	25	3	binding	bind	VERB
biomedich-710	25	4	protein	protein	NOUN
biomedich-710	25	5	5	5	NUM
biomedich-710	25	6	(	(	PUNCT
biomedich-710	25	7	pbp	pbp	NOUN
biomedich-710	25	8	5	5	NUM
biomedich-710	25	9	)	)	PUNCT
biomedich-710	25	10	of	of	ADP
biomedich-710	25	11	e.	e.	PROPN
biomedich-710	25	12	coli	coli	PROPN
biomedich-710	25	13	engages	engage	VERB
biomedich-710	25	14	in	in	ADP
biomedich-710	25	15	cell	cell	NOUN
biomedich-710	25	16	wall	wall	NOUN
biomedich-710	25	17	synthesis	synthesis	PROPN
biomedich-710	25	18	.	.	PUNCT
biomedich-710	26	1	the	the	DET
biomedich-710	26	2	main	main	ADJ
biomedich-710	26	3	constituent	constituent	NOUN
biomedich-710	26	4	of	of	ADP
biomedich-710	26	5	the	the	DET
biomedich-710	26	6	bacterial	bacterial	ADJ
biomedich-710	26	7	cell	cell	NOUN
biomedich-710	26	8	wall	wall	NOUN
biomedich-710	26	9	is	be	AUX
biomedich-710	26	10	peptidoglycan	peptidoglycan	ADJ
biomedich-710	26	11	.	.	PUNCT
biomedich-710	27	1	pbp	pbp	NOUN
biomedich-710	27	2	5	5	NUM
biomedich-710	27	3	enzyme	enzyme	NOUN
biomedich-710	27	4	performs	perform	VERB
biomedich-710	27	5	a	a	DET
biomedich-710	27	6	dd	dd	ADJ
biomedich-710	27	7	-	-	ADJ
biomedich-710	27	8	carboxypeptidase	carboxypeptidase	NOUN
biomedich-710	27	9	reaction	reaction	NOUN
biomedich-710	27	10	on	on	ADP
biomedich-710	27	11	the	the	DET
biomedich-710	27	12	bacterial	bacterial	ADJ
biomedich-710	27	13	peptidoglycan	peptidoglycan	NOUN
biomedich-710	27	14	.	.	PUNCT
biomedich-710	28	1	the	the	DET
biomedich-710	28	2	active	active	ADJ
biomedich-710	28	3	site	site	NOUN
biomedich-710	28	4	of	of	ADP
biomedich-710	28	5	pbp	pbp	NOUN
biomedich-710	28	6	5	5	NUM
biomedich-710	28	7	contains	contain	VERB
biomedich-710	28	8	a	a	DET
biomedich-710	28	9	specific	specific	ADJ
biomedich-710	28	10	serine	serine	NOUN
biomedich-710	28	11	residue	residue	NOUN
biomedich-710	28	12	,	,	PUNCT
biomedich-710	28	13	which	which	PRON
biomedich-710	28	14	acts	act	VERB
biomedich-710	28	15	like	like	ADP
biomedich-710	28	16	a	a	DET
biomedich-710	28	17	hook	hook	NOUN
biomedich-710	28	18	to	to	PART
biomedich-710	28	19	grab	grab	VERB
biomedich-710	28	20	a	a	DET
biomedich-710	28	21	unit	unit	NOUN
biomedich-710	28	22	of	of	ADP
biomedich-710	28	23	the	the	DET
biomedich-710	28	24	peptidoglycan	peptidoglycan	ADJ
biomedich-710	28	25	chain	chain	NOUN
biomedich-710	28	26	during	during	ADP
biomedich-710	28	27	the	the	DET
biomedich-710	28	28	https://doi.org/10.14421/biomedich.2025.141.541-552	https://doi.org/10.14421/biomedich.2025.141.541-552	PRON
biomedich-710	28	29	542	542	NUM
biomedich-710	28	30	biology	biology	NOUN
biomedich-710	28	31	,	,	PUNCT
biomedich-710	28	32	medicine	medicine	NOUN
biomedich-710	28	33	,	,	PUNCT
biomedich-710	28	34	&	&	CCONJ
biomedich-710	28	35	natural	natural	ADJ
biomedich-710	28	36	product	product	NOUN
biomedich-710	28	37	chemistry	chemistry	NOUN
biomedich-710	28	38	14	14	NUM
biomedich-710	28	39	(	(	PUNCT
biomedich-710	28	40	1	1	NUM
biomedich-710	28	41	)	)	PUNCT
biomedich-710	28	42	,	,	PUNCT
biomedich-710	28	43	2025	2025	NUM
biomedich-710	28	44	:	:	PUNCT
biomedich-710	28	45	541	541	NUM
biomedich-710	28	46	-	-	SYM
biomedich-710	28	47	552	552	NUM
biomedich-710	28	48	enzymatic	enzymatic	ADJ
biomedich-710	28	49	reaction	reaction	NOUN
biomedich-710	28	50	.	.	PUNCT
biomedich-710	29	1	near	near	ADP
biomedich-710	29	2	the	the	DET
biomedich-710	29	3	active	active	ADJ
biomedich-710	29	4	site	site	NOUN
biomedich-710	29	5	,	,	PUNCT
biomedich-710	29	6	two	two	NUM
biomedich-710	29	7	lysine	lysine	NOUN
biomedich-710	29	8	residues	residue	NOUN
biomedich-710	29	9	(	(	PUNCT
biomedich-710	29	10	lys47	lys47	NOUN
biomedich-710	29	11	and	and	CCONJ
biomedich-710	29	12	lys213	lys213	PROPN
biomedich-710	29	13	)	)	PUNCT
biomedich-710	29	14	play	play	VERB
biomedich-710	29	15	a	a	DET
biomedich-710	29	16	critical	critical	ADJ
biomedich-710	29	17	role	role	NOUN
biomedich-710	29	18	in	in	ADP
biomedich-710	29	19	proton	proton	NOUN
biomedich-710	29	20	-	-	PUNCT
biomedich-710	29	21	transfer	transfer	NOUN
biomedich-710	29	22	events	event	NOUN
biomedich-710	29	23	during	during	ADP
biomedich-710	29	24	acylation	acylation	NOUN
biomedich-710	29	25	and	and	CCONJ
biomedich-710	29	26	deacylation	deacylation	NOUN
biomedich-710	29	27	events	event	NOUN
biomedich-710	29	28	(	(	PUNCT
biomedich-710	29	29	zhang	zhang	X
biomedich-710	29	30	et	et	PROPN
biomedich-710	29	31	al	al	PROPN
biomedich-710	29	32	.	.	PROPN
biomedich-710	29	33	,	,	PUNCT
biomedich-710	29	34	2007	2007	NUM
biomedich-710	29	35	)	)	PUNCT
biomedich-710	29	36	.	.	PUNCT
biomedich-710	30	1	pbp	pbp	NOUN
biomedich-710	30	2	5	5	NUM
biomedich-710	30	3	can	can	AUX
biomedich-710	30	4	be	be	AUX
biomedich-710	30	5	inactivated	inactivate	VERB
biomedich-710	30	6	by	by	ADP
biomedich-710	30	7	β	β	NOUN
biomedich-710	30	8	-	-	NOUN
biomedich-710	30	9	lactam	lactam	NOUN
biomedich-710	30	10	antibiotics	antibiotic	NOUN
biomedich-710	30	11	such	such	ADJ
biomedich-710	30	12	as	as	ADP
biomedich-710	30	13	penicillin	penicillin	PROPN
biomedich-710	30	14	.	.	PUNCT
biomedich-710	31	1	inactivation	inactivation	NOUN
biomedich-710	31	2	occurs	occur	VERB
biomedich-710	31	3	when	when	SCONJ
biomedich-710	31	4	the	the	DET
biomedich-710	31	5	antibiotic	antibiotic	ADJ
biomedich-710	31	6	forms	form	VERB
biomedich-710	31	7	a	a	DET
biomedich-710	31	8	covalent	covalent	ADJ
biomedich-710	31	9	bond	bond	NOUN
biomedich-710	31	10	with	with	ADP
biomedich-710	31	11	a	a	DET
biomedich-710	31	12	serine	serine	ADJ
biomedich-710	31	13	residue	residue	NOUN
biomedich-710	31	14	in	in	ADP
biomedich-710	31	15	pbp	pbp	NOUN
biomedich-710	31	16	5	5	NUM
biomedich-710	31	17	,	,	PUNCT
biomedich-710	31	18	creating	create	VERB
biomedich-710	31	19	a	a	DET
biomedich-710	31	20	stable	stable	ADJ
biomedich-710	31	21	complex	complex	NOUN
biomedich-710	31	22	that	that	PRON
biomedich-710	31	23	inhibits	inhibit	VERB
biomedich-710	31	24	the	the	DET
biomedich-710	31	25	protein	protein	NOUN
biomedich-710	31	26	’s	’s	PART
biomedich-710	31	27	enzymatic	enzymatic	ADJ
biomedich-710	31	28	activity	activity	NOUN
biomedich-710	31	29	and	and	CCONJ
biomedich-710	31	30	disrupts	disrupt	VERB
biomedich-710	31	31	its	its	PRON
biomedich-710	31	32	normal	normal	ADJ
biomedich-710	31	33	function	function	NOUN
biomedich-710	31	34	.	.	PUNCT
biomedich-710	32	1	when	when	SCONJ
biomedich-710	32	2	pbp	pbp	NOUN
biomedich-710	32	3	5	5	NUM
biomedich-710	32	4	binds	bind	VERB
biomedich-710	32	5	to	to	ADP
biomedich-710	32	6	the	the	DET
biomedich-710	32	7	antibiotic	antibiotic	NOUN
biomedich-710	32	8	,	,	PUNCT
biomedich-710	32	9	it	it	PRON
biomedich-710	32	10	is	be	AUX
biomedich-710	32	11	dormant	dormant	ADJ
biomedich-710	32	12	in	in	ADP
biomedich-710	32	13	an	an	DET
biomedich-710	32	14	acylation	acylation	NOUN
biomedich-710	32	15	state	state	NOUN
biomedich-710	32	16	,	,	PUNCT
biomedich-710	32	17	thus	thus	ADV
biomedich-710	32	18	,	,	PUNCT
biomedich-710	32	19	disrupting	disrupt	VERB
biomedich-710	32	20	the	the	DET
biomedich-710	32	21	cell	cell	NOUN
biomedich-710	32	22	wall	wall	NOUN
biomedich-710	32	23	synthesis	synthesis	NOUN
biomedich-710	32	24	,	,	PUNCT
biomedich-710	32	25	and	and	CCONJ
biomedich-710	32	26	resulting	result	VERB
biomedich-710	32	27	in	in	ADP
biomedich-710	32	28	cell	cell	NOUN
biomedich-710	32	29	death	death	NOUN
biomedich-710	32	30	(	(	PUNCT
biomedich-710	32	31	nicholas	nicholas	PROPN
biomedich-710	32	32	et	et	PROPN
biomedich-710	32	33	al	al	PROPN
biomedich-710	32	34	.	.	PROPN
biomedich-710	32	35	,	,	PUNCT
biomedich-710	32	36	2003	2003	NUM
biomedich-710	32	37	)	)	PUNCT
biomedich-710	32	38	.	.	PUNCT
biomedich-710	33	1	dna	dna	PROPN
biomedich-710	33	2	topoisomerase	topoisomerase	VERB
biomedich-710	33	3	iv	iv	NUM
biomedich-710	33	4	subunit	subunit	NOUN
biomedich-710	33	5	b	b	PROPN
biomedich-710	33	6	(	(	PUNCT
biomedich-710	33	7	pare	pare	PROPN
biomedich-710	33	8	24kda	24kda	NOUN
biomedich-710	33	9	)	)	PUNCT
biomedich-710	33	10	of	of	ADP
biomedich-710	33	11	escherichia	escherichia	NOUN
biomedich-710	33	12	coli	coli	NOUN
biomedich-710	33	13	(	(	PUNCT
biomedich-710	33	14	e.	e.	NOUN
biomedich-710	33	15	coli	coli	PROPN
biomedich-710	33	16	)	)	PUNCT
biomedich-710	33	17	is	be	AUX
biomedich-710	33	18	an	an	DET
biomedich-710	33	19	important	important	ADJ
biomedich-710	33	20	enzyme	enzyme	NOUN
biomedich-710	33	21	that	that	PRON
biomedich-710	33	22	regulates	regulate	VERB
biomedich-710	33	23	dna	dna	PROPN
biomedich-710	33	24	topology	topology	NOUN
biomedich-710	33	25	during	during	ADP
biomedich-710	33	26	replication	replication	NOUN
biomedich-710	33	27	and	and	CCONJ
biomedich-710	33	28	transcription	transcription	NOUN
biomedich-710	33	29	.	.	PUNCT
biomedich-710	34	1	its	its	PRON
biomedich-710	34	2	primary	primary	ADJ
biomedich-710	34	3	role	role	NOUN
biomedich-710	34	4	is	be	AUX
biomedich-710	34	5	to	to	PART
biomedich-710	34	6	separate	separate	VERB
biomedich-710	34	7	the	the	DET
biomedich-710	34	8	intertwined	intertwine	VERB
biomedich-710	34	9	daughter	daughter	NOUN
biomedich-710	34	10	chromosomes	chromosome	NOUN
biomedich-710	34	11	after	after	ADP
biomedich-710	34	12	dna	dna	PROPN
biomedich-710	34	13	replication	replication	NOUN
biomedich-710	34	14	,	,	PUNCT
biomedich-710	34	15	ensuring	ensure	VERB
biomedich-710	34	16	that	that	SCONJ
biomedich-710	34	17	genetic	genetic	ADJ
biomedich-710	34	18	material	material	NOUN
biomedich-710	34	19	is	be	AUX
biomedich-710	34	20	correctly	correctly	ADV
biomedich-710	34	21	distributed	distribute	VERB
biomedich-710	34	22	to	to	ADP
biomedich-710	34	23	daughter	daughter	NOUN
biomedich-710	34	24	cells	cell	NOUN
biomedich-710	34	25	.	.	PUNCT
biomedich-710	35	1	pare	pare	NOUN
biomedich-710	35	2	functions	function	NOUN
biomedich-710	35	3	with	with	ADP
biomedich-710	35	4	another	another	DET
biomedich-710	35	5	subunit	subunit	NOUN
biomedich-710	35	6	,	,	PUNCT
biomedich-710	35	7	parc	parc	NOUN
biomedich-710	35	8	,	,	PUNCT
biomedich-710	35	9	to	to	PART
biomedich-710	35	10	form	form	VERB
biomedich-710	35	11	a	a	DET
biomedich-710	35	12	heterotetrameric	heterotetrameric	ADJ
biomedich-710	35	13	complex	complex	NOUN
biomedich-710	35	14	(	(	PUNCT
biomedich-710	35	15	c2e2	c2e2	PROPN
biomedich-710	35	16	)	)	PUNCT
biomedich-710	35	17	that	that	PRON
biomedich-710	35	18	utilizes	utilize	VERB
biomedich-710	35	19	the	the	DET
biomedich-710	35	20	energy	energy	NOUN
biomedich-710	35	21	derived	derive	VERB
biomedich-710	35	22	from	from	ADP
biomedich-710	35	23	atp	atp	NOUN
biomedich-710	35	24	hydrolysis	hydrolysis	NOUN
biomedich-710	35	25	to	to	PART
biomedich-710	35	26	introduce	introduce	VERB
biomedich-710	35	27	and	and	CCONJ
biomedich-710	35	28	relax	relax	VERB
biomedich-710	35	29	supercoils	supercoil	NOUN
biomedich-710	35	30	in	in	ADP
biomedich-710	35	31	dna	dna	PROPN
biomedich-710	35	32	(	(	PUNCT
biomedich-710	35	33	bellon	bellon	NOUN
biomedich-710	35	34	et	et	PROPN
biomedich-710	35	35	al	al	PROPN
biomedich-710	35	36	.	.	PROPN
biomedich-710	35	37	,	,	PUNCT
biomedich-710	35	38	2004	2004	NUM
biomedich-710	35	39	)	)	PUNCT
biomedich-710	35	40	.	.	PUNCT
biomedich-710	36	1	materials	material	NOUN
biomedich-710	36	2	and	and	CCONJ
biomedich-710	36	3	methods	method	NOUN
biomedich-710	36	4	ligand	ligand	PROPN
biomedich-710	36	5	preparation	preparation	NOUN
biomedich-710	36	6	:	:	PUNCT
biomedich-710	36	7	phytochemicals	phytochemical	NOUN
biomedich-710	36	8	of	of	ADP
biomedich-710	36	9	coccinia	coccinia	NOUN
biomedich-710	36	10	grandis	grandis	PROPN
biomedich-710	36	11	leaves	leave	VERB
biomedich-710	36	12	identified	identify	VERB
biomedich-710	36	13	through	through	ADP
biomedich-710	36	14	a	a	DET
biomedich-710	36	15	literature	literature	NOUN
biomedich-710	36	16	survey	survey	NOUN
biomedich-710	36	17	.	.	PUNCT
biomedich-710	37	1	the	the	DET
biomedich-710	37	2	structure	structure	NOUN
biomedich-710	37	3	of	of	ADP
biomedich-710	37	4	the	the	DET
biomedich-710	37	5	active	active	ADJ
biomedich-710	37	6	site	site	NOUN
biomedich-710	37	7	of	of	ADP
biomedich-710	37	8	e.	e.	PROPN
biomedich-710	37	9	coli	coli	PROPN
biomedich-710	37	10	pbp	pbp	NOUN
biomedich-710	37	11	5	5	NUM
biomedich-710	37	12	was	be	AUX
biomedich-710	37	13	also	also	ADV
biomedich-710	37	14	obtained	obtain	VERB
biomedich-710	37	15	through	through	ADP
biomedich-710	37	16	literature	literature	NOUN
biomedich-710	37	17	survey	survey	NOUN
biomedich-710	37	18	.	.	PUNCT
biomedich-710	38	1	the	the	DET
biomedich-710	38	2	structures	structure	NOUN
biomedich-710	38	3	of	of	ADP
biomedich-710	38	4	selected	select	VERB
biomedich-710	38	5	molecules	molecule	NOUN
biomedich-710	38	6	obtained	obtain	VERB
biomedich-710	38	7	from	from	ADP
biomedich-710	38	8	pubchem	pubchem	NOUN
biomedich-710	38	9	database	database	NOUN
biomedich-710	38	10	(	(	PUNCT
biomedich-710	38	11	pubchem	pubchem	NOUN
biomedich-710	38	12	,	,	PUNCT
biomedich-710	38	13	n.d	n.d	PROPN
biomedich-710	38	14	.	.	PROPN
biomedich-710	38	15	)	)	PUNCT
biomedich-710	38	16	in	in	ADP
biomedich-710	38	17	.sdf	.sdf	PROPN
biomedich-710	38	18	format	format	NOUN
biomedich-710	38	19	.	.	PUNCT
biomedich-710	39	1	the	the	DET
biomedich-710	39	2	energy	energy	NOUN
biomedich-710	39	3	-	-	PUNCT
biomedich-710	39	4	minimization	minimization	NOUN
biomedich-710	39	5	of	of	ADP
biomedich-710	39	6	ligands	ligand	NOUN
biomedich-710	39	7	was	be	AUX
biomedich-710	39	8	performed	perform	VERB
biomedich-710	39	9	using	use	VERB
biomedich-710	39	10	avogadro	avogadro	PROPN
biomedich-710	39	11	(	(	PUNCT
biomedich-710	39	12	version	version	NOUN
biomedich-710	39	13	1.2.0	1.2.0	NUM
biomedich-710	39	14	)	)	PUNCT
biomedich-710	39	15	software	software	NOUN
biomedich-710	39	16	and	and	CCONJ
biomedich-710	39	17	saved	save	VERB
biomedich-710	39	18	in	in	ADP
biomedich-710	39	19	.pdb	.pdb	PROPN
biomedich-710	39	20	format	format	NOUN
biomedich-710	39	21	.	.	PUNCT
biomedich-710	40	1	figure	figure	NOUN
biomedich-710	40	2	1	1	NUM
biomedich-710	40	3	.	.	PUNCT
biomedich-710	41	1	(	(	PUNCT
biomedich-710	41	2	a	a	X
biomedich-710	41	3	)	)	PUNCT
biomedich-710	41	4	crystal	crystal	NOUN
biomedich-710	41	5	structure	structure	NOUN
biomedich-710	41	6	of	of	ADP
biomedich-710	41	7	escherichia	escherichia	NOUN
biomedich-710	41	8	coli	coli	NOUN
biomedich-710	41	9	pbp	pbp	NOUN
biomedich-710	41	10	5	5	NUM
biomedich-710	41	11	in	in	ADP
biomedich-710	41	12	complex	complex	NOUN
biomedich-710	41	13	with	with	ADP
biomedich-710	41	14	a	a	DET
biomedich-710	41	15	peptide	peptide	NOUN
biomedich-710	41	16	-	-	PUNCT
biomedich-710	41	17	mimetic	mimetic	ADJ
biomedich-710	41	18	penicillin	penicillin	NOUN
biomedich-710	41	19	pdb	pdb	PROPN
biomedich-710	41	20	doi	doi	PROPN
biomedich-710	41	21	:	:	PUNCT
biomedich-710	41	22	https://doi.org/10.2210/pdb3beb/pdb	https://doi.org/10.2210/pdb3beb/pdb	NOUN
biomedich-710	41	23	,	,	PUNCT
biomedich-710	41	24	(	(	PUNCT
biomedich-710	41	25	b	b	NOUN
biomedich-710	41	26	)	)	PUNCT
biomedich-710	41	27	crystal	crystal	NOUN
biomedich-710	41	28	structure	structure	NOUN
biomedich-710	41	29	of	of	ADP
biomedich-710	41	30	e.	e.	PROPN
biomedich-710	41	31	coli	coli	PROPN
biomedich-710	41	32	topoisomerase	topoisomerase	NOUN
biomedich-710	41	33	iv	iv	NUM
biomedich-710	41	34	pare	pare	NOUN
biomedich-710	41	35	24kda	24kda	NOUN
biomedich-710	41	36	subunit	subunit	NOUN
biomedich-710	41	37	pdb	pdb	PROPN
biomedich-710	41	38	doi	doi	PROPN
biomedich-710	41	39	:	:	PUNCT
biomedich-710	41	40	https://doi.org/10.2210/pdb1s14/pdb	https://doi.org/10.2210/pdb1s14/pdb	NUM
biomedich-710	41	41	,	,	PUNCT
biomedich-710	41	42	(	(	PUNCT
biomedich-710	41	43	c	c	X
biomedich-710	41	44	)	)	PUNCT
biomedich-710	41	45	crystal	crystal	NOUN
biomedich-710	41	46	structure	structure	NOUN
biomedich-710	41	47	of	of	ADP
biomedich-710	41	48	s.	s.	PROPN
biomedich-710	41	49	aureus	aureus	PROPN
biomedich-710	41	50	pare	pare	PROPN
biomedich-710	41	51	24kda	24kda	NOUN
biomedich-710	41	52	in	in	ADP
biomedich-710	41	53	complex	complex	NOUN
biomedich-710	41	54	with	with	ADP
biomedich-710	41	55	novobiocin	novobiocin	PROPN
biomedich-710	41	56	pdb	pdb	PROPN
biomedich-710	41	57	doi	doi	PROPN
biomedich-710	41	58	:	:	PUNCT
biomedich-710	41	59	https://doi.org/10.2210/pdb4urn/pdb	https://doi.org/10.2210/pdb4urn/pdb	ADV
biomedich-710	41	60	,	,	PUNCT
biomedich-710	41	61	(	(	PUNCT
biomedich-710	41	62	d	d	NOUN
biomedich-710	41	63	)	)	PUNCT
biomedich-710	41	64	structure	structure	NOUN
biomedich-710	41	65	of	of	ADP
biomedich-710	41	66	active	active	ADJ
biomedich-710	41	67	site	site	NOUN
biomedich-710	41	68	of	of	ADP
biomedich-710	41	69	e.	e.	PROPN
biomedich-710	41	70	coli	coli	PROPN
biomedich-710	41	71	pbp	pbp	PROPN
biomedich-710	41	72	5	5	NUM
biomedich-710	41	73	(	(	PUNCT
biomedich-710	41	74	sauvage	sauvage	PROPN
biomedich-710	41	75	et	et	PROPN
biomedich-710	41	76	al	al	PROPN
biomedich-710	41	77	.	.	PROPN
biomedich-710	41	78	,	,	PUNCT
biomedich-710	41	79	2008	2008	NUM
biomedich-710	41	80	)	)	PUNCT
biomedich-710	41	81	,	,	PUNCT
biomedich-710	41	82	(	(	PUNCT
biomedich-710	41	83	e	e	NOUN
biomedich-710	41	84	)	)	PUNCT
biomedich-710	41	85	structure	structure	NOUN
biomedich-710	41	86	of	of	ADP
biomedich-710	41	87	active	active	ADJ
biomedich-710	41	88	site	site	NOUN
biomedich-710	41	89	of	of	ADP
biomedich-710	41	90	e.	e.	PROPN
biomedich-710	41	91	coli	coli	PROPN
biomedich-710	41	92	pare	pare	PROPN
biomedich-710	41	93	24kda	24kda	NOUN
biomedich-710	41	94	(	(	PUNCT
biomedich-710	41	95	bellon	bellon	NOUN
biomedich-710	41	96	et	et	PROPN
biomedich-710	41	97	al	al	PROPN
biomedich-710	41	98	.	.	PROPN
biomedich-710	41	99	,	,	PUNCT
biomedich-710	41	100	2004	2004	NUM
biomedich-710	41	101	)	)	PUNCT
biomedich-710	41	102	(	(	PUNCT
biomedich-710	41	103	f	f	X
biomedich-710	41	104	)	)	PUNCT
biomedich-710	41	105	structure	structure	NOUN
biomedich-710	41	106	of	of	ADP
biomedich-710	41	107	active	active	ADJ
biomedich-710	41	108	site	site	NOUN
biomedich-710	41	109	of	of	ADP
biomedich-710	41	110	s.	s.	PROPN
biomedich-710	41	111	aureus	aureus	PROPN
biomedich-710	41	112	pare	pare	PROPN
biomedich-710	41	113	24kda	24kda	PROPN
biomedich-710	41	114	(	(	PUNCT
biomedich-710	41	115	lu	lu	NOUN
biomedich-710	41	116	et	et	PROPN
biomedich-710	41	117	al	al	PROPN
biomedich-710	41	118	.	.	PROPN
biomedich-710	41	119	,	,	PUNCT
biomedich-710	41	120	2014b	2014b	NUM
biomedich-710	41	121	)	)	PUNCT
biomedich-710	41	122	.	.	PUNCT
biomedich-710	42	1	protein	protein	NOUN
biomedich-710	42	2	preparation	preparation	NOUN
biomedich-710	42	3	:	:	PUNCT
biomedich-710	42	4	the	the	DET
biomedich-710	42	5	crystal	crystal	NOUN
biomedich-710	42	6	structures	structure	NOUN
biomedich-710	42	7	of	of	ADP
biomedich-710	42	8	proteins	protein	NOUN
biomedich-710	42	9	were	be	AUX
biomedich-710	42	10	obtained	obtain	VERB
biomedich-710	42	11	from	from	ADP
biomedich-710	42	12	protein	protein	NOUN
biomedich-710	42	13	data	datum	NOUN
biomedich-710	42	14	bank	bank	NOUN
biomedich-710	42	15	in	in	ADP
biomedich-710	42	16	.pdb	.pdb	PROPN
biomedich-710	42	17	format	format	NOUN
biomedich-710	42	18	(	(	PUNCT
biomedich-710	42	19	pdb	pdb	PROPN
biomedich-710	42	20	i	i	PROPN
biomedich-710	42	21	d	d	PROPN
biomedich-710	42	22	–	–	PUNCT
biomedich-710	42	23	3beb	3beb	NUM
biomedich-710	42	24	:	:	PUNCT
biomedich-710	42	25	crystal	crystal	NOUN
biomedich-710	42	26	structure	structure	NOUN
biomedich-710	42	27	of	of	ADP
biomedich-710	42	28	e.	e.	PROPN
biomedich-710	42	29	coli	coli	PROPN
biomedich-710	42	30	penicillin	penicillin	NOUN
biomedich-710	42	31	-	-	PUNCT
biomedich-710	42	32	binding	bind	VERB
biomedich-710	42	33	protein	protein	NOUN
biomedich-710	42	34	5	5	NUM
biomedich-710	42	35	in	in	ADP
biomedich-710	42	36	complex	complex	NOUN
biomedich-710	42	37	with	with	ADP
biomedich-710	42	38	a	a	DET
biomedich-710	42	39	peptide	peptide	NOUN
biomedich-710	42	40	-	-	PUNCT
biomedich-710	42	41	mimetic	mimetic	ADJ
biomedich-710	42	42	penicillin	penicillin	NOUN
biomedich-710	42	43	pdb	pdb	PROPN
biomedich-710	42	44	doi	doi	PROPN
biomedich-710	42	45	:	:	PUNCT
biomedich-710	42	46	https://doi.org/10.2210/pdb3beb/pdb	https://doi.org/10.2210/pdb3beb/pdb	PROPN
biomedich-710	42	47	(	(	PUNCT
biomedich-710	42	48	sauvage	sauvage	PROPN
biomedich-710	42	49	et	et	PROPN
biomedich-710	42	50	al	al	PROPN
biomedich-710	42	51	.	.	PROPN
biomedich-710	42	52	,	,	PUNCT
biomedich-710	42	53	2008	2008	NUM
biomedich-710	42	54	)	)	PUNCT
biomedich-710	42	55	,	,	PUNCT
biomedich-710	42	56	pdb	pdb	PROPN
biomedich-710	43	1	i	i	PROPN
biomedich-710	43	2	d	d	PROPN
biomedich-710	43	3	–	–	PUNCT
biomedich-710	43	4	1s14	1s14	NUM
biomedich-710	43	5	:	:	PUNCT
biomedich-710	43	6	crystal	crystal	NOUN
biomedich-710	43	7	structure	structure	NOUN
biomedich-710	43	8	of	of	ADP
biomedich-710	43	9	escherichia	escherichia	NOUN
biomedich-710	43	10	coli	coli	NOUN
biomedich-710	43	11	topoisomerase	topoisomerase	NOUN
biomedich-710	43	12	iv	iv	NUM
biomedich-710	43	13	pare	pare	NOUN
biomedich-710	43	14	24kda	24kda	NOUN
biomedich-710	43	15	subunit	subunit	NOUN
biomedich-710	43	16	pdb	pdb	PROPN
biomedich-710	43	17	doi	doi	PROPN
biomedich-710	43	18	:	:	PUNCT
biomedich-710	43	19	https://doi.org/10.2210/pdb1s14/pdb	https://doi.org/10.2210/pdb1s14/pdb	X
biomedich-710	43	20	(	(	PUNCT
biomedich-710	43	21	bellon	bellon	NOUN
biomedich-710	43	22	et	et	PROPN
biomedich-710	43	23	al	al	PROPN
biomedich-710	43	24	.	.	PROPN
biomedich-710	43	25	,	,	PUNCT
biomedich-710	43	26	2004	2004	NUM
biomedich-710	43	27	)	)	PUNCT
biomedich-710	43	28	,	,	PUNCT
biomedich-710	43	29	pdb	pdb	PROPN
biomedich-710	44	1	i	i	PROPN
biomedich-710	44	2	d	d	PROPN
biomedich-710	44	3	–	–	PUNCT
biomedich-710	44	4	4urn	4urn	NOUN
biomedich-710	44	5	:	:	PUNCT
biomedich-710	44	6	crystal	crystal	NOUN
biomedich-710	44	7	structure	structure	NOUN
biomedich-710	44	8	of	of	ADP
biomedich-710	44	9	staph	staph	NOUN
biomedich-710	44	10	pare	pare	NOUN
biomedich-710	44	11	24kda	24kda	NOUN
biomedich-710	44	12	in	in	ADP
biomedich-710	44	13	complex	complex	NOUN
biomedich-710	44	14	with	with	ADP
biomedich-710	44	15	novobiocin	novobiocin	PROPN
biomedich-710	44	16	–	–	PUNCT
biomedich-710	44	17	pdb	pdb	PROPN
biomedich-710	44	18	doi	doi	NOUN
biomedich-710	44	19	:	:	PUNCT
biomedich-710	44	20	https://doi.org/10.2210/pdb4urn/pdb	https://doi.org/10.2210/pdb4urn/pdb	ADV
biomedich-710	44	21	(	(	PUNCT
biomedich-710	44	22	lu	lu	INTJ
biomedich-710	44	23	et	et	PROPN
biomedich-710	44	24	al	al	PROPN
biomedich-710	44	25	.	.	PROPN
biomedich-710	44	26	,	,	PUNCT
biomedich-710	44	27	2014	2014	NUM
biomedich-710	44	28	)	)	PUNCT
biomedich-710	44	29	.	.	PUNCT
biomedich-710	45	1	the	the	DET
biomedich-710	45	2	protein	protein	NOUN
biomedich-710	45	3	was	be	AUX
biomedich-710	45	4	prepared	prepare	VERB
biomedich-710	45	5	using	use	VERB
biomedich-710	45	6	autodocktools	autodocktool	NOUN
biomedich-710	45	7	(	(	PUNCT
biomedich-710	45	8	version	version	NOUN
biomedich-710	45	9	1.5.7	1.5.7	NUM
biomedich-710	45	10	)	)	PUNCT
biomedich-710	45	11	.	.	PUNCT
biomedich-710	46	1	heteroatoms	heteroatom	NOUN
biomedich-710	46	2	and	and	CCONJ
biomedich-710	46	3	water	water	NOUN
biomedich-710	46	4	molecules	molecule	NOUN
biomedich-710	46	5	were	be	AUX
biomedich-710	46	6	removed	remove	VERB
biomedich-710	46	7	,	,	PUNCT
biomedich-710	46	8	and	and	CCONJ
biomedich-710	46	9	polar	polar	ADJ
biomedich-710	46	10	hydrogen	hydrogen	NOUN
biomedich-710	46	11	and	and	CCONJ
biomedich-710	46	12	kollman	kollman	NOUN
biomedich-710	46	13	chargers	charger	NOUN
biomedich-710	46	14	were	be	AUX
biomedich-710	46	15	added	add	VERB
biomedich-710	46	16	to	to	ADP
biomedich-710	46	17	the	the	DET
biomedich-710	46	18	protein	protein	NOUN
biomedich-710	46	19	.	.	PUNCT
biomedich-710	47	1	ad4	ad4	PROPN
biomedich-710	47	2	type	type	NOUN
biomedich-710	47	3	atoms	atom	NOUN
biomedich-710	47	4	were	be	AUX
biomedich-710	47	5	assigned	assign	VERB
biomedich-710	47	6	to	to	ADP
biomedich-710	47	7	the	the	DET
biomedich-710	47	8	protein	protein	NOUN
biomedich-710	47	9	.	.	PUNCT
biomedich-710	48	1	molecular	molecular	ADJ
biomedich-710	48	2	docking	docking	NOUN
biomedich-710	48	3	:	:	PUNCT
biomedich-710	48	4	autodock	autodock	NOUN
biomedich-710	48	5	version	version	NOUN
biomedich-710	48	6	4.2.6	4.2.6	PRON
biomedich-710	48	7	was	be	AUX
biomedich-710	48	8	used	use	VERB
biomedich-710	48	9	to	to	PART
biomedich-710	48	10	perform	perform	VERB
biomedich-710	48	11	site	site	NOUN
biomedich-710	48	12	-	-	PUNCT
biomedich-710	48	13	specific	specific	ADJ
biomedich-710	48	14	molecular	molecular	ADJ
biomedich-710	48	15	docking	docking	NOUN
biomedich-710	48	16	and	and	CCONJ
biomedich-710	48	17	results	result	NOUN
biomedich-710	48	18	were	be	AUX
biomedich-710	48	19	generated	generate	VERB
biomedich-710	48	20	in	in	ADP
biomedich-710	48	21	.dlg	.dlg	PROPN
biomedich-710	48	22	format	format	NOUN
biomedich-710	48	23	(	(	PUNCT
biomedich-710	48	24	output	output	NOUN
biomedich-710	48	25	–	–	PUNCT
biomedich-710	48	26	lamarckianga-4.2	lamarckianga-4.2	NOUN
biomedich-710	48	27	)	)	PUNCT
biomedich-710	48	28	.	.	PUNCT
biomedich-710	49	1	the	the	DET
biomedich-710	49	2	grid	grid	NOUN
biomedich-710	49	3	parameters	parameter	NOUN
biomedich-710	49	4	were	be	AUX
biomedich-710	49	5	set	set	VERB
biomedich-710	49	6	to	to	PART
biomedich-710	49	7	cover	cover	VERB
biomedich-710	49	8	the	the	DET
biomedich-710	49	9	active	active	ADJ
biomedich-710	49	10	site	site	NOUN
biomedich-710	49	11	of	of	ADP
biomedich-710	49	12	each	each	DET
biomedich-710	49	13	protein	protein	NOUN
biomedich-710	49	14	complex	complex	NOUN
biomedich-710	49	15	.	.	PUNCT
biomedich-710	50	1	a	a	DET
biomedich-710	50	2	b	b	X
biomedich-710	50	3	c	c	NOUN
biomedich-710	50	4	d	d	X
biomedich-710	50	5	e	e	X
biomedich-710	50	6	f	f	PROPN
biomedich-710	50	7	isuranga	isuranga	PROPN
biomedich-710	50	8	&	&	CCONJ
biomedich-710	50	9	danthanarayana	danthanarayana	PROPN
biomedich-710	50	10	–	–	PUNCT
biomedich-710	50	11	antimicrobial	antimicrobial	ADJ
biomedich-710	50	12	potential	potential	NOUN
biomedich-710	50	13	of	of	ADP
biomedich-710	50	14	phytochemicals	phytochemical	NOUN
biomedich-710	50	15	from	from	ADP
biomedich-710	50	16	coccinia	coccinia	NOUN
biomedich-710	50	17	grandis	grandis	NOUN
biomedich-710	50	18	…	…	PUNCT
biomedich-710	50	19	543	543	NUM
biomedich-710	50	20	table	table	NOUN
biomedich-710	50	21	1	1	NUM
biomedich-710	50	22	.	.	PUNCT
biomedich-710	50	23	grid	grid	NOUN
biomedich-710	50	24	map	map	NOUN
biomedich-710	50	25	dimensions	dimension	NOUN
biomedich-710	50	26	(	(	PUNCT
biomedich-710	50	27	a0	a0	NOUN
biomedich-710	50	28	)	)	PUNCT
biomedich-710	50	29	and	and	CCONJ
biomedich-710	50	30	grid	grid	NOUN
biomedich-710	50	31	-	-	PUNCT
biomedich-710	50	32	center	center	NOUN
biomedich-710	50	33	coordinates	coordinate	NOUN
biomedich-710	50	34	(	(	PUNCT
biomedich-710	50	35	a0	a0	PROPN
biomedich-710	50	36	)	)	PUNCT
biomedich-710	50	37	.	.	PUNCT
biomedich-710	51	1	protein	protein	NOUN
biomedich-710	51	2	complex	complex	ADJ
biomedich-710	51	3	grid	grid	NOUN
biomedich-710	51	4	map	map	NOUN
biomedich-710	51	5	dimensions	dimension	NOUN
biomedich-710	51	6	(	(	PUNCT
biomedich-710	51	7	a0	a0	NOUN
biomedich-710	51	8	)	)	PUNCT
biomedich-710	51	9	grid	grid	NOUN
biomedich-710	51	10	-	-	PUNCT
biomedich-710	51	11	center	center	NOUN
biomedich-710	51	12	coordinates	coordinate	NOUN
biomedich-710	51	13	(	(	PUNCT
biomedich-710	51	14	a0	a0	NOUN
biomedich-710	51	15	)	)	PUNCT
biomedich-710	51	16	x	x	NOUN
biomedich-710	51	17	-	-	NOUN
biomedich-710	51	18	axis	axis	ADJ
biomedich-710	51	19	y	y	NOUN
biomedich-710	51	20	-	-	PUNCT
biomedich-710	51	21	axis	axis	NOUN
biomedich-710	51	22	z	z	NOUN
biomedich-710	51	23	-	-	PUNCT
biomedich-710	51	24	axis	axis	NOUN
biomedich-710	51	25	x	x	ADJ
biomedich-710	51	26	-	-	ADJ
biomedich-710	51	27	axis	axis	ADJ
biomedich-710	51	28	y	y	NOUN
biomedich-710	51	29	-	-	PUNCT
biomedich-710	51	30	axis	axis	NOUN
biomedich-710	51	31	z	z	NOUN
biomedich-710	51	32	-	-	PUNCT
biomedich-710	51	33	axis	axis	ADJ
biomedich-710	51	34	e.	e.	PROPN
biomedich-710	51	35	coli	coli	PROPN
biomedich-710	51	36	pbp	pbp	PROPN
biomedich-710	51	37	5	5	NUM
biomedich-710	51	38	15.8	15.8	NUM
biomedich-710	51	39	26.3	26.3	NUM
biomedich-710	51	40	16.5	16.5	NUM
biomedich-710	51	41	42.732	42.732	NUM
biomedich-710	51	42	4.638	4.638	NUM
biomedich-710	51	43	26.112	26.112	NUM
biomedich-710	51	44	e.	e.	PROPN
biomedich-710	51	45	coli	coli	PROPN
biomedich-710	51	46	pare	pare	PROPN
biomedich-710	51	47	24kda	24kda	NOUN
biomedich-710	51	48	subunit	subunit	NOUN
biomedich-710	51	49	18.0	18.0	NUM
biomedich-710	51	50	18.0	18.0	NUM
biomedich-710	51	51	17.3	17.3	NUM
biomedich-710	51	52	19.236	19.236	NUM
biomedich-710	51	53	26.093	26.093	NUM
biomedich-710	51	54	48.526	48.526	NUM
biomedich-710	51	55	staph	staph	NOUN
biomedich-710	51	56	pare	pare	NOUN
biomedich-710	51	57	24kda	24kda	NOUN
biomedich-710	51	58	subunit	subunit	NOUN
biomedich-710	51	59	17.3	17.3	NUM
biomedich-710	51	60	21.0	21.0	NUM
biomedich-710	51	61	19.5	19.5	NUM
biomedich-710	51	62	-27.52	-27.52	NUM
biomedich-710	51	63	5.92	5.92	NUM
biomedich-710	51	64	0.958	0.958	NUM
biomedich-710	51	65	the	the	DET
biomedich-710	51	66	genetic	genetic	ADJ
biomedich-710	51	67	algorithm	algorithm	NOUN
biomedich-710	51	68	(	(	PUNCT
biomedich-710	51	69	ga	ga	NOUN
biomedich-710	51	70	)	)	PUNCT
biomedich-710	51	71	parameters	parameter	NOUN
biomedich-710	51	72	were	be	AUX
biomedich-710	51	73	set	set	VERB
biomedich-710	51	74	to	to	ADP
biomedich-710	51	75	50	50	NUM
biomedich-710	51	76	runs	run	NOUN
biomedich-710	51	77	with	with	ADP
biomedich-710	51	78	300	300	NUM
biomedich-710	51	79	population	population	NOUN
biomedich-710	51	80	size	size	NOUN
biomedich-710	51	81	.	.	PUNCT
biomedich-710	52	1	the	the	DET
biomedich-710	52	2	maximum	maximum	ADJ
biomedich-710	52	3	number	number	NOUN
biomedich-710	52	4	of	of	ADP
biomedich-710	52	5	evaluations	evaluation	NOUN
biomedich-710	52	6	:	:	PUNCT
biomedich-710	52	7	25,000,000	25,000,000	NUM
biomedich-710	52	8	(	(	PUNCT
biomedich-710	52	9	medium	medium	NOUN
biomedich-710	52	10	)	)	PUNCT
biomedich-710	52	11	and	and	CCONJ
biomedich-710	52	12	maximum	maximum	ADJ
biomedich-710	52	13	number	number	NOUN
biomedich-710	52	14	of	of	ADP
biomedich-710	52	15	generations	generation	NOUN
biomedich-710	52	16	27	27	NUM
biomedich-710	52	17	000	000	NUM
biomedich-710	52	18	(	(	PUNCT
biomedich-710	52	19	lawan	lawan	PROPN
biomedich-710	52	20	&	&	CCONJ
biomedich-710	52	21	tharakee	tharakee	PROPN
biomedich-710	52	22	,	,	PUNCT
biomedich-710	52	23	2023	2023	NUM
biomedich-710	52	24	)	)	PUNCT
biomedich-710	52	25	.	.	PUNCT
biomedich-710	53	1	molecular	molecular	ADJ
biomedich-710	53	2	dynamics	dynamic	NOUN
biomedich-710	53	3	simulation	simulation	NOUN
biomedich-710	53	4	:	:	PUNCT
biomedich-710	53	5	the	the	DET
biomedich-710	53	6	site	site	NOUN
biomedich-710	53	7	-	-	PUNCT
biomedich-710	53	8	specific	specific	ADJ
biomedich-710	53	9	molecular	molecular	ADJ
biomedich-710	53	10	docking	docking	NOUN
biomedich-710	53	11	results	result	NOUN
biomedich-710	53	12	were	be	AUX
biomedich-710	53	13	analyzed	analyze	VERB
biomedich-710	53	14	using	use	VERB
biomedich-710	53	15	autodocktools	autodocktool	NOUN
biomedich-710	53	16	(	(	PUNCT
biomedich-710	53	17	version	version	NOUN
biomedich-710	53	18	1.5.7	1.5.7	NUM
biomedich-710	53	19	)	)	PUNCT
biomedich-710	53	20	.	.	PUNCT
biomedich-710	54	1	binding	bind	VERB
biomedich-710	54	2	energies	energy	NOUN
biomedich-710	54	3	and	and	CCONJ
biomedich-710	54	4	inhibition	inhibition	NOUN
biomedich-710	54	5	constants	constant	NOUN
biomedich-710	54	6	were	be	AUX
biomedich-710	54	7	examined	examine	VERB
biomedich-710	54	8	,	,	PUNCT
biomedich-710	54	9	and	and	CCONJ
biomedich-710	54	10	the	the	DET
biomedich-710	54	11	interactions	interaction	NOUN
biomedich-710	54	12	were	be	AUX
biomedich-710	54	13	visualized	visualize	VERB
biomedich-710	54	14	using	use	VERB
biomedich-710	54	15	discovery	discovery	NOUN
biomedich-710	54	16	studio	studio	NOUN
biomedich-710	54	17	visualizer	visualizer	NOUN
biomedich-710	54	18	(	(	PUNCT
biomedich-710	54	19	v24.1.0.23298	v24.1.0.23298	NUM
biomedich-710	54	20	)	)	PUNCT
biomedich-710	54	21	.	.	PUNCT
biomedich-710	55	1	drug	drug	NOUN
biomedich-710	55	2	-	-	PUNCT
biomedich-710	55	3	likeness	likeness	NOUN
biomedich-710	55	4	and	and	CCONJ
biomedich-710	55	5	pharmacokinetics	pharmacokinetic	NOUN
biomedich-710	55	6	of	of	ADP
biomedich-710	55	7	selected	select	VERB
biomedich-710	55	8	molecules	molecule	NOUN
biomedich-710	55	9	:	:	PUNCT
biomedich-710	55	10	the	the	DET
biomedich-710	55	11	potential	potential	NOUN
biomedich-710	55	12	of	of	ADP
biomedich-710	55	13	selected	select	VERB
biomedich-710	55	14	molecules	molecule	NOUN
biomedich-710	55	15	as	as	SCONJ
biomedich-710	55	16	drugs	drug	NOUN
biomedich-710	55	17	was	be	AUX
biomedich-710	55	18	evaluated	evaluate	VERB
biomedich-710	55	19	by	by	ADP
biomedich-710	55	20	assessing	assess	VERB
biomedich-710	55	21	their	their	PRON
biomedich-710	55	22	drug	drug	NOUN
biomedich-710	55	23	-	-	PUNCT
biomedich-710	55	24	likeness	likeness	NOUN
biomedich-710	55	25	and	and	CCONJ
biomedich-710	55	26	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	55	27	properties	property	NOUN
biomedich-710	55	28	.	.	PUNCT
biomedich-710	56	1	pharmacokinetics	pharmacokinetic	NOUN
biomedich-710	56	2	parameters	parameter	NOUN
biomedich-710	56	3	of	of	ADP
biomedich-710	56	4	the	the	DET
biomedich-710	56	5	selected	select	VERB
biomedich-710	56	6	molecules	molecule	NOUN
biomedich-710	56	7	were	be	AUX
biomedich-710	56	8	predicted	predict	VERB
biomedich-710	56	9	using	use	VERB
biomedich-710	56	10	the	the	DET
biomedich-710	56	11	pkcsm	pkcsm	NOUN
biomedich-710	56	12	server	server	NOUN
biomedich-710	56	13	(	(	PUNCT
biomedich-710	56	14	https://biosig.lab.uq.edu.au/pkcsm/prediction	https://biosig.lab.uq.edu.au/pkcsm/prediction	NOUN
biomedich-710	56	15	)	)	PUNCT
biomedich-710	56	16	and	and	CCONJ
biomedich-710	56	17	swissadme	swissadme	NOUN
biomedich-710	56	18	(	(	PUNCT
biomedich-710	56	19	http://www.swissadme.ch/index.php	http://www.swissadme.ch/index.php	INTJ
biomedich-710	56	20	)	)	PUNCT
biomedich-710	56	21	.	.	PUNCT
biomedich-710	57	1	these	these	DET
biomedich-710	57	2	parameters	parameter	NOUN
biomedich-710	57	3	describe	describe	VERB
biomedich-710	57	4	how	how	SCONJ
biomedich-710	57	5	a	a	DET
biomedich-710	57	6	drug	drug	NOUN
biomedich-710	57	7	behaves	behave	VERB
biomedich-710	57	8	in	in	ADP
biomedich-710	57	9	the	the	DET
biomedich-710	57	10	body	body	NOUN
biomedich-710	57	11	including	include	VERB
biomedich-710	57	12	absorption	absorption	NOUN
biomedich-710	57	13	,	,	PUNCT
biomedich-710	57	14	distribution	distribution	NOUN
biomedich-710	57	15	,	,	PUNCT
biomedich-710	57	16	metabolism	metabolism	NOUN
biomedich-710	57	17	,	,	PUNCT
biomedich-710	57	18	excretion	excretion	NOUN
biomedich-710	57	19	,	,	PUNCT
biomedich-710	57	20	and	and	CCONJ
biomedich-710	57	21	toxicity	toxicity	NOUN
biomedich-710	57	22	(	(	PUNCT
biomedich-710	57	23	table	table	NOUN
biomedich-710	57	24	9	9	NUM
biomedich-710	57	25	)	)	PUNCT
biomedich-710	57	26	.	.	PUNCT
biomedich-710	58	1	the	the	DET
biomedich-710	58	2	drug	drug	NOUN
biomedich-710	58	3	-	-	PUNCT
biomedich-710	58	4	likeness	likeness	NOUN
biomedich-710	58	5	of	of	ADP
biomedich-710	58	6	the	the	DET
biomedich-710	58	7	molecules	molecule	NOUN
biomedich-710	58	8	was	be	AUX
biomedich-710	58	9	analyzed	analyze	VERB
biomedich-710	58	10	using	use	VERB
biomedich-710	58	11	swissadme	swissadme	NOUN
biomedich-710	58	12	(	(	PUNCT
biomedich-710	58	13	http://www.swissadme.ch/index.php	http://www.swissadme.ch/index.php	INTJ
biomedich-710	58	14	)	)	PUNCT
biomedich-710	58	15	,	,	PUNCT
biomedich-710	58	16	which	which	PRON
biomedich-710	58	17	evaluates	evaluate	VERB
biomedich-710	58	18	molecules	molecule	NOUN
biomedich-710	58	19	against	against	ADP
biomedich-710	58	20	lipinski	lipinski	PROPN
biomedich-710	58	21	’s	’s	PART
biomedich-710	58	22	rule	rule	NOUN
biomedich-710	58	23	of	of	ADP
biomedich-710	58	24	five	five	NUM
biomedich-710	58	25	(	(	PUNCT
biomedich-710	58	26	lipinski	lipinski	PROPN
biomedich-710	58	27	et	et	PROPN
biomedich-710	58	28	al	al	PROPN
biomedich-710	58	29	.	.	PROPN
biomedich-710	58	30	,	,	PUNCT
biomedich-710	58	31	2001	2001	NUM
biomedich-710	58	32	)	)	PUNCT
biomedich-710	58	33	and	and	CCONJ
biomedich-710	58	34	verber	verber	PROPN
biomedich-710	58	35	’s	’s	PART
biomedich-710	58	36	rules	rule	NOUN
biomedich-710	58	37	(	(	PUNCT
biomedich-710	58	38	veber	veber	PROPN
biomedich-710	58	39	et	et	PROPN
biomedich-710	58	40	al	al	PROPN
biomedich-710	58	41	.	.	PROPN
biomedich-710	58	42	,	,	PUNCT
biomedich-710	58	43	2002	2002	NUM
biomedich-710	58	44	)	)	PUNCT
biomedich-710	58	45	(	(	PUNCT
biomedich-710	58	46	table	table	NOUN
biomedich-710	58	47	8)	8)	NUM
biomedich-710	58	48	.	.	PUNCT
biomedich-710	59	1	docking	dock	VERB
biomedich-710	59	2	validation	validation	NOUN
biomedich-710	59	3	(	(	PUNCT
biomedich-710	59	4	quality	quality	NOUN
biomedich-710	59	5	control	control	NOUN
biomedich-710	59	6	):	):	PUNCT
biomedich-710	59	7	the	the	DET
biomedich-710	59	8	docking	docking	NOUN
biomedich-710	59	9	procedure	procedure	NOUN
biomedich-710	59	10	was	be	AUX
biomedich-710	59	11	validated	validate	VERB
biomedich-710	59	12	by	by	ADP
biomedich-710	59	13	removing	remove	VERB
biomedich-710	59	14	the	the	DET
biomedich-710	59	15	inhibitor	inhibitor	NOUN
biomedich-710	59	16	from	from	ADP
biomedich-710	59	17	each	each	DET
biomedich-710	59	18	obtained	obtain	VERB
biomedich-710	59	19	protein	protein	NOUN
biomedich-710	59	20	complex	complex	NOUN
biomedich-710	59	21	and	and	CCONJ
biomedich-710	59	22	redocking	redocke	VERB
biomedich-710	59	23	the	the	DET
biomedich-710	59	24	inhibitor	inhibitor	NOUN
biomedich-710	59	25	.	.	PUNCT
biomedich-710	60	1	the	the	DET
biomedich-710	60	2	re	re	ADJ
biomedich-710	60	3	-	-	ADJ
biomedich-710	60	4	docked	docked	ADJ
biomedich-710	60	5	complex	complex	NOUN
biomedich-710	60	6	was	be	AUX
biomedich-710	60	7	aligned	align	VERB
biomedich-710	60	8	with	with	ADP
biomedich-710	60	9	the	the	DET
biomedich-710	60	10	reference	reference	NOUN
biomedich-710	60	11	crystalized	crystalize	VERB
biomedich-710	60	12	complex	complex	ADJ
biomedich-710	60	13	using	use	VERB
biomedich-710	60	14	pymol	pymol	NOUN
biomedich-710	60	15	(	(	PUNCT
biomedich-710	60	16	version	version	NOUN
biomedich-710	60	17	2.5.8	2.5.8	NUM
biomedich-710	60	18	)	)	PUNCT
biomedich-710	60	19	,	,	PUNCT
biomedich-710	60	20	and	and	CCONJ
biomedich-710	60	21	the	the	DET
biomedich-710	60	22	difference	difference	NOUN
biomedich-710	60	23	in	in	ADP
biomedich-710	60	24	their	their	PRON
biomedich-710	60	25	positions	position	NOUN
biomedich-710	60	26	was	be	AUX
biomedich-710	60	27	measured	measure	VERB
biomedich-710	60	28	using	use	VERB
biomedich-710	60	29	the	the	DET
biomedich-710	60	30	root	root	NOUN
biomedich-710	60	31	mean	mean	ADJ
biomedich-710	60	32	square	square	ADJ
biomedich-710	60	33	deviation	deviation	NOUN
biomedich-710	60	34	(	(	PUNCT
biomedich-710	60	35	rmsd	rmsd	NOUN
biomedich-710	60	36	)	)	PUNCT
biomedich-710	60	37	(	(	PUNCT
biomedich-710	60	38	shivanika	shivanika	X
biomedich-710	60	39	et	et	PROPN
biomedich-710	60	40	al	al	PROPN
biomedich-710	60	41	.	.	PROPN
biomedich-710	60	42	,	,	PUNCT
biomedich-710	60	43	2022	2022	NUM
biomedich-710	60	44	)	)	PUNCT
biomedich-710	60	45	.	.	PUNCT
biomedich-710	61	1	results	result	NOUN
biomedich-710	61	2	table	table	VERB
biomedich-710	61	3	2	2	NUM
biomedich-710	61	4	.	.	PUNCT
biomedich-710	61	5	calculated	calculate	VERB
biomedich-710	61	6	binding	bind	VERB
biomedich-710	61	7	energies	energy	NOUN
biomedich-710	61	8	and	and	CCONJ
biomedich-710	61	9	inhibition	inhibition	VERB
biomedich-710	61	10	constants	constant	NOUN
biomedich-710	61	11	of	of	ADP
biomedich-710	61	12	selected	select	VERB
biomedich-710	61	13	molecules	molecule	NOUN
biomedich-710	61	14	against	against	ADP
biomedich-710	61	15	pbp	pbp	NOUN
biomedich-710	61	16	5	5	NUM
biomedich-710	61	17	of	of	ADP
biomedich-710	61	18	e.	e.	PROPN
biomedich-710	61	19	coli	coli	PROPN
biomedich-710	61	20	.	.	PUNCT
biomedich-710	62	1	molecule	molecule	NOUN
biomedich-710	62	2	reference	reference	NOUN
biomedich-710	62	3	rmsd	rmsd	NOUN
biomedich-710	62	4	(	(	PUNCT
biomedich-710	62	5	a0	a0	NOUN
biomedich-710	62	6	)	)	PUNCT
biomedich-710	62	7	binding	bind	VERB
biomedich-710	62	8	energy	energy	NOUN
biomedich-710	62	9	(	(	PUNCT
biomedich-710	62	10	kcal	kcal	NOUN
biomedich-710	62	11	/	/	SYM
biomedich-710	62	12	mol	mol	NOUN
biomedich-710	62	13	)	)	PUNCT
biomedich-710	62	14	inhibition	inhibition	VERB
biomedich-710	62	15	constant	constant	ADJ
biomedich-710	62	16	-	-	PUNCT
biomedich-710	62	17	ki	ki	PROPN
biomedich-710	62	18	(	(	PUNCT
biomedich-710	62	19	µm	µm	NOUN
biomedich-710	62	20	)	)	PUNCT
biomedich-710	62	21	at	at	ADP
biomedich-710	62	22	298.15	298.15	NUM
biomedich-710	62	23	k	k	PROPN
biomedich-710	62	24	penicillin	penicillin	PROPN
biomedich-710	62	25	51.41	51.41	NUM
biomedich-710	62	26	-7.20	-7.20	NUM
biomedich-710	62	27	5.32	5.32	NUM
biomedich-710	62	28	quercetin	quercetin	NOUN
biomedich-710	62	29	49.21	49.21	NUM
biomedich-710	62	30	-6.19	-6.19	NUM
biomedich-710	62	31	28.88	28.88	NUM
biomedich-710	62	32	kaempferol	kaempferol	NOUN
biomedich-710	62	33	49.70	49.70	NUM
biomedich-710	62	34	-5.90	-5.90	NUM
biomedich-710	62	35	47.19	47.19	NUM
biomedich-710	62	36	naringenin	naringenin	NOUN
biomedich-710	62	37	51.17	51.17	NUM
biomedich-710	62	38	-6.27	-6.27	PROPN
biomedich-710	62	39	25.47	25.47	NUM
biomedich-710	62	40	isoquercetin	isoquercetin	NOUN
biomedich-710	62	41	51.46	51.46	NUM
biomedich-710	62	42	-6.08	-6.08	NUM
biomedich-710	62	43	34.69	34.69	NUM
biomedich-710	62	44	lupeol	lupeol	NOUN
biomedich-710	62	45	49.67	49.67	NUM
biomedich-710	62	46	-7.72	-7.72	NUM
biomedich-710	62	47	2.19	2.19	NUM
biomedich-710	62	48	beta	beta	NOUN
biomedich-710	62	49	-	-	PUNCT
biomedich-710	62	50	sitosterol	sitosterol	NOUN
biomedich-710	62	51	47.94	47.94	NUM
biomedich-710	62	52	-8.21	-8.21	NUM
biomedich-710	62	53	0.953	0.953	NUM
biomedich-710	62	54	rutin	rutin	NOUN
biomedich-710	62	55	50.44	50.44	NUM
biomedich-710	62	56	-5.24	-5.24	NUM
biomedich-710	62	57	143.35	143.35	NUM
biomedich-710	62	58	sanguinarine	sanguinarine	NOUN
biomedich-710	62	59	48.95	48.95	NUM
biomedich-710	62	60	-6.53	-6.53	NUM
biomedich-710	62	61	16.23	16.23	NUM
biomedich-710	62	62	p	p	ADJ
biomedich-710	62	63	-	-	PUNCT
biomedich-710	62	64	coumaric	coumaric	ADJ
biomedich-710	62	65	acid	acid	NOUN
biomedich-710	62	66	unsuccessful	unsuccessful	ADJ
biomedich-710	62	67	table	table	NOUN
biomedich-710	62	68	3	3	NUM
biomedich-710	62	69	.	.	PUNCT
biomedich-710	62	70	calculated	calculate	VERB
biomedich-710	62	71	binding	bind	VERB
biomedich-710	62	72	energies	energy	NOUN
biomedich-710	62	73	and	and	CCONJ
biomedich-710	62	74	inhibition	inhibition	VERB
biomedich-710	62	75	constants	constant	NOUN
biomedich-710	62	76	of	of	ADP
biomedich-710	62	77	selected	select	VERB
biomedich-710	62	78	molecules	molecule	NOUN
biomedich-710	62	79	against	against	ADP
biomedich-710	62	80	topoisomerase	topoisomerase	NOUN
biomedich-710	62	81	iv	iv	NUM
biomedich-710	62	82	pare	pare	NOUN
biomedich-710	62	83	24kda	24kda	NOUN
biomedich-710	62	84	subunit	subunit	NOUN
biomedich-710	62	85	of	of	ADP
biomedich-710	62	86	e.	e.	PROPN
biomedich-710	62	87	coli	coli	PROPN
biomedich-710	62	88	.	.	PUNCT
biomedich-710	63	1	molecule	molecule	NOUN
biomedich-710	63	2	reference	reference	NOUN
biomedich-710	63	3	rmsd	rmsd	NOUN
biomedich-710	63	4	(	(	PUNCT
biomedich-710	63	5	a0	a0	NOUN
biomedich-710	63	6	)	)	PUNCT
biomedich-710	63	7	binding	bind	VERB
biomedich-710	63	8	energy	energy	NOUN
biomedich-710	63	9	(	(	PUNCT
biomedich-710	63	10	kcal	kcal	NOUN
biomedich-710	63	11	/	/	SYM
biomedich-710	63	12	mol	mol	NOUN
biomedich-710	63	13	)	)	PUNCT
biomedich-710	63	14	inhibition	inhibition	VERB
biomedich-710	63	15	constant	constant	ADJ
biomedich-710	63	16	-	-	PUNCT
biomedich-710	63	17	ki	ki	PROPN
biomedich-710	63	18	(	(	PUNCT
biomedich-710	63	19	µm	µm	NOUN
biomedich-710	63	20	)	)	PUNCT
biomedich-710	63	21	at	at	ADP
biomedich-710	63	22	298.15	298.15	NUM
biomedich-710	63	23	k	k	NOUN
biomedich-710	63	24	novobiocin	novobiocin	PROPN
biomedich-710	63	25	57.21	57.21	NUM
biomedich-710	63	26	-5.76	-5.76	NUM
biomedich-710	63	27	60.25	60.25	NUM
biomedich-710	63	28	quercetin	quercetin	NOUN
biomedich-710	63	29	60.87	60.87	NUM
biomedich-710	63	30	-6.85	-6.85	NUM
biomedich-710	63	31	9.45	9.45	NUM
biomedich-710	63	32	kaempferol	kaempferol	NOUN
biomedich-710	63	33	60.68	60.68	NUM
biomedich-710	63	34	-6.82	-6.82	NUM
biomedich-710	63	35	10.08	10.08	NUM
biomedich-710	63	36	naringenin	naringenin	NOUN
biomedich-710	63	37	60.92	60.92	NUM
biomedich-710	63	38	-7.23	-7.23	NUM
biomedich-710	63	39	5.01	5.01	NUM
biomedich-710	63	40	isoquercetin	isoquercetin	NOUN
biomedich-710	63	41	60.71	60.71	NUM
biomedich-710	63	42	-6.20	-6.20	NUM
biomedich-710	63	43	28.57	28.57	NUM
biomedich-710	63	44	lupeol	lupeol	NOUN
biomedich-710	63	45	59.13	59.13	NUM
biomedich-710	63	46	-7.67	-7.67	NUM
biomedich-710	63	47	2.39	2.39	NUM
biomedich-710	63	48	beta	beta	NOUN
biomedich-710	63	49	-	-	PUNCT
biomedich-710	63	50	sitosterol	sitosterol	NOUN
biomedich-710	63	51	58.98	58.98	NUM
biomedich-710	63	52	-9.08	-9.08	NUM
biomedich-710	63	53	222.53	222.53	NUM
biomedich-710	63	54	rutin	rutin	NOUN
biomedich-710	63	55	58.62	58.62	NUM
biomedich-710	63	56	-4.38	-4.38	NOUN
biomedich-710	63	57	611.52	611.52	NUM
biomedich-710	63	58	sanguinarine	sanguinarine	NOUN
biomedich-710	63	59	60.40	60.40	NUM
biomedich-710	63	60	-9.03	-9.03	NUM
biomedich-710	63	61	0.241	0.241	NUM
biomedich-710	63	62	p	p	ADJ
biomedich-710	63	63	-	-	PUNCT
biomedich-710	63	64	coumaric	coumaric	ADJ
biomedich-710	63	65	acid	acid	NOUN
biomedich-710	63	66	unsuccessful	unsuccessful	ADJ
biomedich-710	63	67	544	544	NUM
biomedich-710	63	68	biology	biology	NOUN
biomedich-710	63	69	,	,	PUNCT
biomedich-710	63	70	medicine	medicine	NOUN
biomedich-710	63	71	,	,	PUNCT
biomedich-710	63	72	&	&	CCONJ
biomedich-710	63	73	natural	natural	ADJ
biomedich-710	63	74	product	product	NOUN
biomedich-710	63	75	chemistry	chemistry	NOUN
biomedich-710	63	76	14	14	NUM
biomedich-710	63	77	(	(	PUNCT
biomedich-710	63	78	1	1	NUM
biomedich-710	63	79	)	)	PUNCT
biomedich-710	63	80	,	,	PUNCT
biomedich-710	63	81	2025	2025	NUM
biomedich-710	63	82	:	:	PUNCT
biomedich-710	63	83	541	541	NUM
biomedich-710	63	84	-	-	SYM
biomedich-710	63	85	552	552	NUM
biomedich-710	63	86	table	table	NOUN
biomedich-710	63	87	4	4	NUM
biomedich-710	63	88	.	.	PUNCT
biomedich-710	63	89	calculated	calculate	VERB
biomedich-710	63	90	binding	bind	VERB
biomedich-710	63	91	energies	energy	NOUN
biomedich-710	63	92	and	and	CCONJ
biomedich-710	63	93	inhibition	inhibition	VERB
biomedich-710	63	94	constants	constant	NOUN
biomedich-710	63	95	of	of	ADP
biomedich-710	63	96	selected	select	VERB
biomedich-710	63	97	molecules	molecule	NOUN
biomedich-710	63	98	against	against	ADP
biomedich-710	63	99	topoisomerase	topoisomerase	NOUN
biomedich-710	63	100	iv	iv	NUM
biomedich-710	63	101	pare	pare	NOUN
biomedich-710	63	102	24kda	24kda	NOUN
biomedich-710	63	103	subunit	subunit	NOUN
biomedich-710	63	104	of	of	ADP
biomedich-710	63	105	s.	s.	PROPN
biomedich-710	63	106	aureus	aureus	PROPN
biomedich-710	63	107	.	.	PUNCT
biomedich-710	64	1	molecule	molecule	NOUN
biomedich-710	64	2	reference	reference	NOUN
biomedich-710	64	3	rmsd	rmsd	NOUN
biomedich-710	64	4	(	(	PUNCT
biomedich-710	64	5	a0	a0	NOUN
biomedich-710	64	6	)	)	PUNCT
biomedich-710	64	7	binding	bind	VERB
biomedich-710	64	8	energy	energy	NOUN
biomedich-710	64	9	(	(	PUNCT
biomedich-710	64	10	kcal	kcal	NOUN
biomedich-710	64	11	/	/	SYM
biomedich-710	64	12	mol	mol	NOUN
biomedich-710	64	13	)	)	PUNCT
biomedich-710	64	14	inhibition	inhibition	VERB
biomedich-710	64	15	constant	constant	ADJ
biomedich-710	64	16	-	-	PUNCT
biomedich-710	64	17	ki	ki	PROPN
biomedich-710	64	18	(	(	PUNCT
biomedich-710	64	19	µm	µm	NOUN
biomedich-710	64	20	)	)	PUNCT
biomedich-710	64	21	at	at	ADP
biomedich-710	64	22	298.15	298.15	NUM
biomedich-710	64	23	k	k	NOUN
biomedich-710	64	24	novobiocin	novobiocin	PROPN
biomedich-710	64	25	25.79	25.79	NUM
biomedich-710	64	26	-6.04	-6.04	NUM
biomedich-710	64	27	37.19	37.19	NUM
biomedich-710	64	28	quercetin	quercetin	NOUN
biomedich-710	64	29	24.15	24.15	NUM
biomedich-710	64	30	-6.70	-6.70	NUM
biomedich-710	64	31	12.27	12.27	NUM
biomedich-710	64	32	kaempferol	kaempferol	NOUN
biomedich-710	64	33	25.23	25.23	NUM
biomedich-710	64	34	-6.95	-6.95	NUM
biomedich-710	64	35	7.99	7.99	NUM
biomedich-710	64	36	naringenin	naringenin	NOUN
biomedich-710	64	37	23.41	23.41	NUM
biomedich-710	64	38	-7.07	-7.07	NOUN
biomedich-710	64	39	6.63	6.63	NUM
biomedich-710	64	40	isoquercetin	isoquercetin	NOUN
biomedich-710	64	41	25.88	25.88	NUM
biomedich-710	64	42	-6.15	-6.15	NUM
biomedich-710	64	43	31.28	31.28	NUM
biomedich-710	64	44	lupeol	lupeol	PROPN
biomedich-710	64	45	26.02	26.02	NUM
biomedich-710	64	46	-7.87	-7.87	NUM
biomedich-710	64	47	1.70	1.70	NUM
biomedich-710	64	48	beta	beta	NOUN
biomedich-710	64	49	-	-	PUNCT
biomedich-710	64	50	sitosterol	sitosterol	NOUN
biomedich-710	64	51	23.93	23.93	NUM
biomedich-710	64	52	-9.42	-9.42	NUM
biomedich-710	64	53	0.125	0.125	NUM
biomedich-710	64	54	rutin	rutin	NOUN
biomedich-710	64	55	26.99	26.99	NUM
biomedich-710	64	56	-5.42	-5.42	NUM
biomedich-710	64	57	106.89	106.89	NUM
biomedich-710	64	58	sanguinarine	sanguinarine	NOUN
biomedich-710	64	59	23.39	23.39	NUM
biomedich-710	64	60	-9.07	-9.07	NOUN
biomedich-710	64	61	0.224	0.224	NUM
biomedich-710	64	62	p	p	ADJ
biomedich-710	64	63	-	-	PUNCT
biomedich-710	64	64	coumaric	coumaric	ADJ
biomedich-710	64	65	acid	acid	NOUN
biomedich-710	64	66	unsuccessful	unsuccessful	ADJ
biomedich-710	64	67	figure	figure	NOUN
biomedich-710	64	68	2	2	NUM
biomedich-710	64	69	.	.	PUNCT
biomedich-710	65	1	(	(	PUNCT
biomedich-710	65	2	a	a	X
biomedich-710	65	3	)	)	PUNCT
biomedich-710	65	4	superimposition	superimposition	NOUN
biomedich-710	65	5	of	of	ADP
biomedich-710	65	6	re	re	ADJ
biomedich-710	65	7	-	-	ADJ
biomedich-710	65	8	docked	docked	ADJ
biomedich-710	65	9	penicillin	penicillin	NOUN
biomedich-710	65	10	(	(	PUNCT
biomedich-710	65	11	yellow	yellow	NOUN
biomedich-710	65	12	)	)	PUNCT
biomedich-710	65	13	on	on	ADP
biomedich-710	65	14	active	active	ADJ
biomedich-710	65	15	site	site	NOUN
biomedich-710	65	16	of	of	ADP
biomedich-710	65	17	crystalized	crystalize	VERB
biomedich-710	65	18	structure	structure	NOUN
biomedich-710	65	19	(	(	PUNCT
biomedich-710	65	20	green	green	NOUN
biomedich-710	65	21	)	)	PUNCT
biomedich-710	65	22	of	of	ADP
biomedich-710	65	23	escherichia	escherichia	NOUN
biomedich-710	65	24	coli	coli	NOUN
biomedich-710	65	25	pbp	pbp	NOUN
biomedich-710	65	26	5	5	NUM
biomedich-710	65	27	using	use	VERB
biomedich-710	65	28	pymol	pymol	NOUN
biomedich-710	65	29	(	(	PUNCT
biomedich-710	65	30	rmsd	rmsd	VERB
biomedich-710	65	31	=	=	SYM
biomedich-710	65	32	0.000	0.000	NUM
biomedich-710	65	33	a0	a0	NOUN
biomedich-710	65	34	)	)	PUNCT
biomedich-710	65	35	,	,	PUNCT
biomedich-710	65	36	(	(	PUNCT
biomedich-710	65	37	b	b	X
biomedich-710	65	38	)	)	PUNCT
biomedich-710	65	39	superimposition	superimposition	NOUN
biomedich-710	65	40	of	of	ADP
biomedich-710	65	41	re	re	ADJ
biomedich-710	65	42	-	-	VERB
biomedich-710	65	43	docked	docked	ADJ
biomedich-710	65	44	novobiocin	novobiocin	NOUN
biomedich-710	65	45	(	(	PUNCT
biomedich-710	65	46	yellow	yellow	NOUN
biomedich-710	65	47	)	)	PUNCT
biomedich-710	65	48	on	on	ADP
biomedich-710	65	49	active	active	ADJ
biomedich-710	65	50	site	site	NOUN
biomedich-710	65	51	of	of	ADP
biomedich-710	65	52	crystalized	crystalize	VERB
biomedich-710	65	53	structure	structure	NOUN
biomedich-710	65	54	(	(	PUNCT
biomedich-710	65	55	green	green	NOUN
biomedich-710	65	56	)	)	PUNCT
biomedich-710	65	57	of	of	ADP
biomedich-710	65	58	e.	e.	PROPN
biomedich-710	65	59	coli	coli	PROPN
biomedich-710	65	60	topoisomerase	topoisomerase	NOUN
biomedich-710	65	61	iv	iv	NUM
biomedich-710	65	62	pare	pare	NOUN
biomedich-710	65	63	24kda	24kda	NOUN
biomedich-710	65	64	subunit	subunit	NOUN
biomedich-710	65	65	using	use	VERB
biomedich-710	65	66	pymol	pymol	PROPN
biomedich-710	65	67	(	(	PUNCT
biomedich-710	65	68	rmsd	rmsd	VERB
biomedich-710	65	69	=	=	SYM
biomedich-710	65	70	0.000	0.000	NUM
biomedich-710	65	71	a0	a0	NOUN
biomedich-710	65	72	)	)	PUNCT
biomedich-710	65	73	,	,	PUNCT
biomedich-710	65	74	(	(	PUNCT
biomedich-710	65	75	c	c	X
biomedich-710	65	76	)	)	PUNCT
biomedich-710	65	77	superimposition	superimposition	NOUN
biomedich-710	65	78	of	of	ADP
biomedich-710	65	79	re	re	ADJ
biomedich-710	65	80	-	-	VERB
biomedich-710	65	81	docked	docked	ADJ
biomedich-710	65	82	novobiocin	novobiocin	NOUN
biomedich-710	65	83	(	(	PUNCT
biomedich-710	65	84	yellow	yellow	NOUN
biomedich-710	65	85	)	)	PUNCT
biomedich-710	65	86	on	on	ADP
biomedich-710	65	87	active	active	ADJ
biomedich-710	65	88	site	site	NOUN
biomedich-710	65	89	of	of	ADP
biomedich-710	65	90	crystalized	crystalize	VERB
biomedich-710	65	91	structure	structure	NOUN
biomedich-710	65	92	(	(	PUNCT
biomedich-710	65	93	green	green	NOUN
biomedich-710	65	94	)	)	PUNCT
biomedich-710	65	95	of	of	ADP
biomedich-710	65	96	s.	s.	PROPN
biomedich-710	65	97	aureus	aureus	PROPN
biomedich-710	65	98	pare	pare	PROPN
biomedich-710	65	99	24kda	24kda	NOUN
biomedich-710	65	100	using	use	VERB
biomedich-710	65	101	pymol	pymol	PROPN
biomedich-710	65	102	(	(	PUNCT
biomedich-710	65	103	rmsd	rmsd	VERB
biomedich-710	65	104	=	=	SYM
biomedich-710	65	105	0.000	0.000	NUM
biomedich-710	65	106	a0	a0	NOUN
biomedich-710	65	107	)	)	PUNCT
biomedich-710	65	108	.	.	PUNCT
biomedich-710	66	1	figure	figure	VERB
biomedich-710	66	2	3	3	NUM
biomedich-710	66	3	.	.	PUNCT
biomedich-710	66	4	interactions	interaction	NOUN
biomedich-710	66	5	between	between	ADP
biomedich-710	66	6	selected	select	VERB
biomedich-710	66	7	molecules	molecule	NOUN
biomedich-710	66	8	and	and	CCONJ
biomedich-710	66	9	escherichia	escherichia	NOUN
biomedich-710	66	10	coli	coli	NOUN
biomedich-710	66	11	pbp	pbp	NOUN
biomedich-710	66	12	5	5	NUM
biomedich-710	66	13	(	(	PUNCT
biomedich-710	66	14	a	a	NOUN
biomedich-710	66	15	)	)	PUNCT
biomedich-710	66	16	penicillin	penicillin	NOUN
biomedich-710	66	17	,	,	PUNCT
biomedich-710	66	18	(	(	PUNCT
biomedich-710	66	19	b	b	NOUN
biomedich-710	66	20	)	)	PUNCT
biomedich-710	66	21	quercetin	quercetin	NOUN
biomedich-710	66	22	,	,	PUNCT
biomedich-710	66	23	(	(	PUNCT
biomedich-710	66	24	c	c	NOUN
biomedich-710	66	25	)	)	PUNCT
biomedich-710	66	26	kaempferol	kaempferol	NOUN
biomedich-710	66	27	,	,	PUNCT
biomedich-710	66	28	(	(	PUNCT
biomedich-710	66	29	d	d	X
biomedich-710	66	30	)	)	PUNCT
biomedich-710	66	31	naringenin	naringenin	PROPN
biomedich-710	66	32	,	,	PUNCT
biomedich-710	66	33	(	(	PUNCT
biomedich-710	66	34	e	e	NOUN
biomedich-710	66	35	)	)	PUNCT
biomedich-710	66	36	isoquercetin	isoquercetin	NOUN
biomedich-710	66	37	,	,	PUNCT
biomedich-710	66	38	(	(	PUNCT
biomedich-710	66	39	f	f	X
biomedich-710	66	40	)	)	PUNCT
biomedich-710	66	41	lupeol	lupeol	NOUN
biomedich-710	66	42	,	,	PUNCT
biomedich-710	66	43	(	(	PUNCT
biomedich-710	66	44	g	g	NOUN
biomedich-710	66	45	)	)	PUNCT
biomedich-710	66	46	beta	beta	NOUN
biomedich-710	66	47	-	-	PUNCT
biomedich-710	66	48	sitosterol	sitosterol	NOUN
biomedich-710	66	49	,	,	PUNCT
biomedich-710	66	50	(	(	PUNCT
biomedich-710	66	51	h	h	NOUN
biomedich-710	66	52	)	)	PUNCT
biomedich-710	66	53	rutin	rutin	NOUN
biomedich-710	66	54	,	,	PUNCT
biomedich-710	66	55	(	(	PUNCT
biomedich-710	66	56	i	i	NOUN
biomedich-710	66	57	)	)	PUNCT
biomedich-710	66	58	sanguinarine	sanguinarine	NOUN
biomedich-710	66	59	a	a	DET
biomedich-710	66	60	b	b	NOUN
biomedich-710	66	61	c	c	NOUN
biomedich-710	66	62	e	e	NOUN
biomedich-710	66	63	a	a	PRON
biomedich-710	66	64	b	b	NOUN
biomedich-710	66	65	c	c	NOUN
biomedich-710	67	1	d	d	X
biomedich-710	67	2	f	f	PROPN
biomedich-710	68	1	g	g	NOUN
biomedich-710	68	2	h	h	NOUN
biomedich-710	69	1	i	i	PRON
biomedich-710	69	2	isuranga	isuranga	PROPN
biomedich-710	69	3	&	&	CCONJ
biomedich-710	69	4	danthanarayana	danthanarayana	PROPN
biomedich-710	69	5	–	–	PUNCT
biomedich-710	69	6	antimicrobial	antimicrobial	ADJ
biomedich-710	69	7	potential	potential	NOUN
biomedich-710	69	8	of	of	ADP
biomedich-710	69	9	phytochemicals	phytochemical	NOUN
biomedich-710	69	10	from	from	ADP
biomedich-710	69	11	coccinia	coccinia	NOUN
biomedich-710	69	12	grandis	grandis	NOUN
biomedich-710	69	13	…	…	PUNCT
biomedich-710	69	14	545	545	NUM
biomedich-710	69	15	figure	figure	NOUN
biomedich-710	69	16	4	4	NUM
biomedich-710	69	17	.	.	PUNCT
biomedich-710	69	18	interactions	interaction	NOUN
biomedich-710	69	19	between	between	ADP
biomedich-710	69	20	selected	select	VERB
biomedich-710	69	21	molecules	molecule	NOUN
biomedich-710	69	22	and	and	CCONJ
biomedich-710	69	23	topoisomerase	topoisomerase	NOUN
biomedich-710	69	24	iv	iv	NUM
biomedich-710	69	25	pare	pare	NOUN
biomedich-710	69	26	24kda	24kda	NOUN
biomedich-710	69	27	subunit	subunit	NOUN
biomedich-710	69	28	of	of	ADP
biomedich-710	69	29	e.	e.	PROPN
biomedich-710	69	30	coli	coli	PROPN
biomedich-710	69	31	(	(	PUNCT
biomedich-710	69	32	a	a	X
biomedich-710	69	33	)	)	PUNCT
biomedich-710	69	34	novobiocin	novobiocin	ADJ
biomedich-710	69	35	,	,	PUNCT
biomedich-710	69	36	(	(	PUNCT
biomedich-710	69	37	b	b	NOUN
biomedich-710	69	38	)	)	PUNCT
biomedich-710	69	39	quercetin	quercetin	NOUN
biomedich-710	69	40	,	,	PUNCT
biomedich-710	69	41	(	(	PUNCT
biomedich-710	69	42	c	c	NOUN
biomedich-710	69	43	)	)	PUNCT
biomedich-710	69	44	kaempferol	kaempferol	NOUN
biomedich-710	69	45	,	,	PUNCT
biomedich-710	69	46	(	(	PUNCT
biomedich-710	69	47	d	d	X
biomedich-710	69	48	)	)	PUNCT
biomedich-710	69	49	naringenin	naringenin	PROPN
biomedich-710	69	50	,	,	PUNCT
biomedich-710	69	51	(	(	PUNCT
biomedich-710	69	52	e	e	NOUN
biomedich-710	69	53	)	)	PUNCT
biomedich-710	69	54	isoquercetin	isoquercetin	NOUN
biomedich-710	69	55	,	,	PUNCT
biomedich-710	69	56	(	(	PUNCT
biomedich-710	69	57	f	f	X
biomedich-710	69	58	)	)	PUNCT
biomedich-710	69	59	lupeol	lupeol	NOUN
biomedich-710	69	60	,	,	PUNCT
biomedich-710	69	61	(	(	PUNCT
biomedich-710	69	62	g	g	NOUN
biomedich-710	69	63	)	)	PUNCT
biomedich-710	69	64	beta	beta	NOUN
biomedich-710	69	65	-	-	PUNCT
biomedich-710	69	66	sitosterol	sitosterol	NOUN
biomedich-710	69	67	,	,	PUNCT
biomedich-710	69	68	(	(	PUNCT
biomedich-710	69	69	h	h	NOUN
biomedich-710	69	70	)	)	PUNCT
biomedich-710	69	71	rutin	rutin	NOUN
biomedich-710	69	72	,	,	PUNCT
biomedich-710	69	73	(	(	PUNCT
biomedich-710	69	74	i	i	NOUN
biomedich-710	69	75	)	)	PUNCT
biomedich-710	69	76	sanguinarine	sanguinarine	NOUN
biomedich-710	69	77	.	.	PUNCT
biomedich-710	70	1	figure	figure	NOUN
biomedich-710	70	2	5	5	NUM
biomedich-710	70	3	.	.	PUNCT
biomedich-710	70	4	interactions	interaction	NOUN
biomedich-710	70	5	between	between	ADP
biomedich-710	70	6	selected	select	VERB
biomedich-710	70	7	molecules	molecule	NOUN
biomedich-710	70	8	and	and	CCONJ
biomedich-710	70	9	topoisomerase	topoisomerase	NOUN
biomedich-710	70	10	iv	iv	NUM
biomedich-710	70	11	pare	pare	NOUN
biomedich-710	70	12	24kda	24kda	NOUN
biomedich-710	70	13	subunit	subunit	NOUN
biomedich-710	70	14	of	of	ADP
biomedich-710	70	15	s.	s.	PROPN
biomedich-710	70	16	aureus	aureus	PROPN
biomedich-710	70	17	(	(	PUNCT
biomedich-710	70	18	a	a	X
biomedich-710	70	19	)	)	PUNCT
biomedich-710	70	20	novobiocin	novobiocin	ADJ
biomedich-710	70	21	,	,	PUNCT
biomedich-710	70	22	(	(	PUNCT
biomedich-710	70	23	b	b	NOUN
biomedich-710	70	24	)	)	PUNCT
biomedich-710	70	25	quercetin	quercetin	NOUN
biomedich-710	70	26	,	,	PUNCT
biomedich-710	70	27	(	(	PUNCT
biomedich-710	70	28	c	c	NOUN
biomedich-710	70	29	)	)	PUNCT
biomedich-710	70	30	kaempferol	kaempferol	NOUN
biomedich-710	70	31	,	,	PUNCT
biomedich-710	70	32	(	(	PUNCT
biomedich-710	70	33	d	d	X
biomedich-710	70	34	)	)	PUNCT
biomedich-710	70	35	naringenin	naringenin	PROPN
biomedich-710	70	36	,	,	PUNCT
biomedich-710	70	37	(	(	PUNCT
biomedich-710	70	38	e	e	NOUN
biomedich-710	70	39	)	)	PUNCT
biomedich-710	70	40	isoquercetin	isoquercetin	NOUN
biomedich-710	70	41	,	,	PUNCT
biomedich-710	70	42	(	(	PUNCT
biomedich-710	70	43	f	f	X
biomedich-710	70	44	)	)	PUNCT
biomedich-710	70	45	lupeol	lupeol	NOUN
biomedich-710	70	46	,	,	PUNCT
biomedich-710	70	47	(	(	PUNCT
biomedich-710	70	48	g	g	NOUN
biomedich-710	70	49	)	)	PUNCT
biomedich-710	70	50	beta	beta	NOUN
biomedich-710	70	51	-	-	PUNCT
biomedich-710	70	52	sitosterol	sitosterol	NOUN
biomedich-710	70	53	,	,	PUNCT
biomedich-710	70	54	(	(	PUNCT
biomedich-710	70	55	h	h	NOUN
biomedich-710	70	56	)	)	PUNCT
biomedich-710	70	57	rutin	rutin	NOUN
biomedich-710	70	58	,	,	PUNCT
biomedich-710	70	59	(	(	PUNCT
biomedich-710	70	60	i	i	NOUN
biomedich-710	70	61	)	)	PUNCT
biomedich-710	70	62	sanguinarine	sanguinarine	NOUN
biomedich-710	70	63	.	.	PUNCT
biomedich-710	71	1	a	a	DET
biomedich-710	71	2	b	b	X
biomedich-710	71	3	c	c	NOUN
biomedich-710	71	4	d	d	X
biomedich-710	71	5	e	e	X
biomedich-710	71	6	f	f	PROPN
biomedich-710	71	7	g	g	PROPN
biomedich-710	72	1	h	h	NOUN
biomedich-710	73	1	i	i	PRON
biomedich-710	73	2	a	a	DET
biomedich-710	73	3	b	b	X
biomedich-710	73	4	c	c	NOUN
biomedich-710	73	5	546	546	NUM
biomedich-710	73	6	biology	biology	NOUN
biomedich-710	73	7	,	,	PUNCT
biomedich-710	73	8	medicine	medicine	NOUN
biomedich-710	73	9	,	,	PUNCT
biomedich-710	73	10	&	&	CCONJ
biomedich-710	73	11	natural	natural	ADJ
biomedich-710	73	12	product	product	NOUN
biomedich-710	73	13	chemistry	chemistry	NOUN
biomedich-710	73	14	14	14	NUM
biomedich-710	73	15	(	(	PUNCT
biomedich-710	73	16	1	1	NUM
biomedich-710	73	17	)	)	PUNCT
biomedich-710	73	18	,	,	PUNCT
biomedich-710	73	19	2025	2025	NUM
biomedich-710	73	20	:	:	PUNCT
biomedich-710	73	21	541	541	NUM
biomedich-710	73	22	-	-	SYM
biomedich-710	73	23	552	552	NUM
biomedich-710	73	24	figure	figure	NOUN
biomedich-710	73	25	5	5	NUM
biomedich-710	73	26	.	.	PUNCT
biomedich-710	74	1	cont	cont	PROPN
biomedich-710	74	2	.	.	PUNCT
biomedich-710	74	3	table	table	NOUN
biomedich-710	74	4	5	5	NUM
biomedich-710	74	5	.	.	PUNCT
biomedich-710	75	1	hydrogen	hydrogen	NOUN
biomedich-710	75	2	bonding	bonding	NOUN
biomedich-710	75	3	interactions	interaction	NOUN
biomedich-710	75	4	(	(	PUNCT
biomedich-710	75	5	intermolecular	intermolecular	ADJ
biomedich-710	75	6	conventional	conventional	ADJ
biomedich-710	75	7	hydrogen	hydrogen	NOUN
biomedich-710	75	8	bond	bond	NOUN
biomedich-710	75	9	)	)	PUNCT
biomedich-710	75	10	between	between	ADP
biomedich-710	75	11	ligands	ligand	NOUN
biomedich-710	75	12	and	and	CCONJ
biomedich-710	75	13	pbp	pbp	NOUN
biomedich-710	75	14	5	5	NUM
biomedich-710	75	15	of	of	ADP
biomedich-710	75	16	e.	e.	PROPN
biomedich-710	75	17	coli	coli	PROPN
biomedich-710	75	18	.	.	PUNCT
biomedich-710	76	1	molecule	molecule	NOUN
biomedich-710	76	2	name	name	NOUN
biomedich-710	76	3	distance	distance	NOUN
biomedich-710	76	4	(	(	PUNCT
biomedich-710	76	5	a0	a0	NOUN
biomedich-710	76	6	)	)	PUNCT
biomedich-710	76	7	h	h	NOUN
biomedich-710	76	8	-	-	PUNCT
biomedich-710	76	9	donor	donor	NOUN
biomedich-710	76	10	h	h	NOUN
biomedich-710	76	11	-	-	PUNCT
biomedich-710	76	12	acceptor	acceptor	NOUN
biomedich-710	76	13	dha	dha	PROPN
biomedich-710	76	14	angle	angle	NOUN
biomedich-710	76	15	(	(	PUNCT
biomedich-710	76	16	0	0	NUM
biomedich-710	76	17	)	)	PUNCT
biomedich-710	76	18	penicillin	penicillin	NOUN
biomedich-710	76	19	a	a	DET
biomedich-710	76	20	:	:	PUNCT
biomedich-710	76	21	ser44	ser44	NOUN
biomedich-710	76	22	:	:	PUNCT
biomedich-710	76	23	hg	hg	NOUN
biomedich-710	76	24	:	:	PUNCT
biomedich-710	76	25	unl1	unl1	VERB
biomedich-710	76	26	:	:	PUNCT
biomedich-710	76	27	n	n	PROPN
biomedich-710	76	28	1.70075	1.70075	NUM
biomedich-710	76	29	a	a	DET
biomedich-710	76	30	:	:	PUNCT
biomedich-710	76	31	ser44	ser44	NOUN
biomedich-710	76	32	:	:	PUNCT
biomedich-710	76	33	hg	hg	NOUN
biomedich-710	76	34	:	:	PUNCT
biomedich-710	76	35	unl1	unl1	VERB
biomedich-710	76	36	:	:	PUNCT
biomedich-710	76	37	n	n	PROPN
biomedich-710	76	38	153.622	153.622	NUM
biomedich-710	76	39	a	a	DET
biomedich-710	76	40	:	:	PUNCT
biomedich-710	76	41	ser87	ser87	NOUN
biomedich-710	76	42	:	:	PUNCT
biomedich-710	76	43	hn	hn	PROPN
biomedich-710	76	44	:	:	PUNCT
biomedich-710	76	45	unl1	unl1	ADJ
biomedich-710	76	46	:	:	PUNCT
biomedich-710	76	47	oxt	oxt	NOUN
biomedich-710	76	48	2.15591	2.15591	NUM
biomedich-710	76	49	a	a	DET
biomedich-710	76	50	:	:	PUNCT
biomedich-710	76	51	ser87	ser87	NOUN
biomedich-710	76	52	:	:	PUNCT
biomedich-710	76	53	hn	hn	PROPN
biomedich-710	76	54	:	:	PUNCT
biomedich-710	76	55	unl1	unl1	PROPN
biomedich-710	76	56	:	:	PUNCT
biomedich-710	76	57	oxt	oxt	NOUN
biomedich-710	76	58	163.07	163.07	NUM
biomedich-710	76	59	a	a	DET
biomedich-710	76	60	:	:	PUNCT
biomedich-710	76	61	asn112	asn112	NOUN
biomedich-710	76	62	:	:	PUNCT
biomedich-710	76	63	hd21	hd21	PROPN
biomedich-710	76	64	:	:	PUNCT
biomedich-710	76	65	unl1	unl1	ADJ
biomedich-710	76	66	:	:	PUNCT
biomedich-710	76	67	oxt	oxt	NOUN
biomedich-710	76	68	2.10638	2.10638	NUM
biomedich-710	76	69	a	a	DET
biomedich-710	76	70	:	:	PUNCT
biomedich-710	76	71	asn112	asn112	NOUN
biomedich-710	76	72	:	:	PUNCT
biomedich-710	76	73	hd21	hd21	PROPN
biomedich-710	76	74	:	:	PUNCT
biomedich-710	76	75	unl1	unl1	PROPN
biomedich-710	76	76	:	:	PUNCT
biomedich-710	76	77	oxt	oxt	PROPN
biomedich-710	76	78	159.893	159.893	NUM
biomedich-710	76	79	lupeol	lupeol	NOUN
biomedich-710	76	80	:	:	PUNCT
biomedich-710	76	81	unl1	unl1	ADJ
biomedich-710	76	82	:	:	PUNCT
biomedich-710	76	83	h	h	NOUN
biomedich-710	76	84	a	a	DET
biomedich-710	76	85	:	:	PUNCT
biomedich-710	76	86	ser44	ser44	NOUN
biomedich-710	76	87	:	:	PUNCT
biomedich-710	76	88	og	og	PROPN
biomedich-710	76	89	1.90396	1.90396	NUM
biomedich-710	76	90	:	:	PUNCT
biomedich-710	76	91	unl1	unl1	ADJ
biomedich-710	76	92	:	:	PUNCT
biomedich-710	76	93	h	h	NOUN
biomedich-710	76	94	a	a	DET
biomedich-710	76	95	:	:	PUNCT
biomedich-710	76	96	ser44	ser44	NOUN
biomedich-710	76	97	:	:	PUNCT
biomedich-710	76	98	og	og	PROPN
biomedich-710	76	99	147.908	147.908	NUM
biomedich-710	76	100	beta	beta	NOUN
biomedich-710	76	101	-	-	PUNCT
biomedich-710	76	102	sitosterol	sitosterol	NOUN
biomedich-710	76	103	:	:	PUNCT
biomedich-710	76	104	unl1	unl1	ADJ
biomedich-710	76	105	:	:	PUNCT
biomedich-710	76	106	h	h	NOUN
biomedich-710	76	107	a	a	DET
biomedich-710	76	108	:	:	PUNCT
biomedich-710	76	109	asn112	asn112	NOUN
biomedich-710	76	110	:	:	PUNCT
biomedich-710	76	111	od1	od1	NOUN
biomedich-710	76	112	2.42915	2.42915	NUM
biomedich-710	76	113	:	:	PUNCT
biomedich-710	76	114	unl1	unl1	ADJ
biomedich-710	76	115	:	:	PUNCT
biomedich-710	76	116	h	h	NOUN
biomedich-710	76	117	a	a	DET
biomedich-710	76	118	:	:	PUNCT
biomedich-710	76	119	asn112	asn112	NOUN
biomedich-710	76	120	:	:	PUNCT
biomedich-710	76	121	od1	od1	NOUN
biomedich-710	76	122	137.911	137.911	NUM
biomedich-710	76	123	table	table	NOUN
biomedich-710	76	124	6	6	NUM
biomedich-710	76	125	.	.	PUNCT
biomedich-710	77	1	hydrogen	hydrogen	NOUN
biomedich-710	77	2	bonding	bonding	NOUN
biomedich-710	77	3	interactions	interaction	NOUN
biomedich-710	77	4	(	(	PUNCT
biomedich-710	77	5	intermolecular	intermolecular	ADJ
biomedich-710	77	6	conventional	conventional	ADJ
biomedich-710	77	7	hydrogen	hydrogen	NOUN
biomedich-710	77	8	bond	bond	NOUN
biomedich-710	77	9	)	)	PUNCT
biomedich-710	77	10	between	between	ADP
biomedich-710	77	11	ligands	ligand	NOUN
biomedich-710	77	12	and	and	CCONJ
biomedich-710	77	13	topoisomerase	topoisomerase	NOUN
biomedich-710	77	14	iv	iv	NUM
biomedich-710	77	15	pare	pare	NOUN
biomedich-710	77	16	24kda	24kda	NOUN
biomedich-710	77	17	subunit	subunit	NOUN
biomedich-710	77	18	of	of	ADP
biomedich-710	77	19	e.	e.	PROPN
biomedich-710	77	20	coli	coli	PROPN
biomedich-710	77	21	.	.	PUNCT
biomedich-710	78	1	molecule	molecule	NOUN
biomedich-710	78	2	name	name	NOUN
biomedich-710	78	3	distance	distance	NOUN
biomedich-710	78	4	(	(	PUNCT
biomedich-710	78	5	a0	a0	NOUN
biomedich-710	78	6	)	)	PUNCT
biomedich-710	78	7	h	h	NOUN
biomedich-710	78	8	-	-	PUNCT
biomedich-710	78	9	donor	donor	NOUN
biomedich-710	78	10	h	h	NOUN
biomedich-710	78	11	-	-	PUNCT
biomedich-710	78	12	acceptor	acceptor	NOUN
biomedich-710	78	13	dha	dha	PROPN
biomedich-710	78	14	angle	angle	NOUN
biomedich-710	78	15	(	(	PUNCT
biomedich-710	78	16	0	0	NUM
biomedich-710	78	17	)	)	PUNCT
biomedich-710	78	18	novobiocin	novobiocin	VERB
biomedich-710	78	19	a	a	DET
biomedich-710	78	20	:	:	PUNCT
biomedich-710	78	21	his1079	his1079	NOUN
biomedich-710	78	22	:	:	PUNCT
biomedich-710	78	23	he2	he2	PROPN
biomedich-710	78	24	:	:	PUNCT
biomedich-710	78	25	unl1	unl1	PROPN
biomedich-710	78	26	:o	:o	PUNCT
biomedich-710	79	1	2.89395	2.89395	NUM
biomedich-710	79	2	a	a	DET
biomedich-710	79	3	:	:	PUNCT
biomedich-710	79	4	his1079	his1079	NOUN
biomedich-710	79	5	:	:	PUNCT
biomedich-710	79	6	he2	he2	PROPN
biomedich-710	79	7	:	:	PUNCT
biomedich-710	79	8	unl1	unl1	VERB
biomedich-710	79	9	:o	:o	PUNCT
biomedich-710	79	10	112.624	112.624	NUM
biomedich-710	79	11	:	:	PUNCT
biomedich-710	79	12	unl1	unl1	ADJ
biomedich-710	79	13	:	:	PUNCT
biomedich-710	79	14	h	h	NOUN
biomedich-710	79	15	a	a	PRON
biomedich-710	79	16	:	:	PUNCT
biomedich-710	79	17	ile1078	ile1078	ADJ
biomedich-710	79	18	:o	:o	NOUN
biomedich-710	79	19	2.44228	2.44228	NUM
biomedich-710	79	20	:	:	PUNCT
biomedich-710	79	21	unl1	unl1	ADJ
biomedich-710	79	22	:	:	PUNCT
biomedich-710	79	23	h	h	NOUN
biomedich-710	79	24	a	a	PRON
biomedich-710	79	25	:	:	PUNCT
biomedich-710	79	26	ile1078	ile1078	ADJ
biomedich-710	79	27	:o	:o	PROPN
biomedich-710	79	28	176.688	176.688	NUM
biomedich-710	79	29	quercetin	quercetin	NOUN
biomedich-710	79	30	a	a	DET
biomedich-710	79	31	:	:	PUNCT
biomedich-710	79	32	asn1042	asn1042	NOUN
biomedich-710	79	33	:	:	PUNCT
biomedich-710	79	34	hd21	hd21	PROPN
biomedich-710	79	35	:	:	PUNCT
biomedich-710	79	36	unl1	unl1	PROPN
biomedich-710	79	37	:o	:o	PROPN
biomedich-710	80	1	2.88793	2.88793	NUM
biomedich-710	80	2	a	a	DET
biomedich-710	80	3	:	:	PUNCT
biomedich-710	80	4	asn1042	asn1042	NOUN
biomedich-710	80	5	:	:	PUNCT
biomedich-710	80	6	hd21	hd21	PROPN
biomedich-710	80	7	:	:	PUNCT
biomedich-710	80	8	unl1	unl1	PROPN
biomedich-710	80	9	:o	:o	PROPN
biomedich-710	80	10	101.638	101.638	NUM
biomedich-710	80	11	:	:	PUNCT
biomedich-710	80	12	unl1	unl1	ADJ
biomedich-710	80	13	:	:	PUNCT
biomedich-710	80	14	h	h	NOUN
biomedich-710	80	15	a	a	DET
biomedich-710	80	16	:	:	PUNCT
biomedich-710	80	17	glu1046	glu1046	NOUN
biomedich-710	80	18	:	:	PUNCT
biomedich-710	80	19	oe1	oe1	PROPN
biomedich-710	80	20	2.19212	2.19212	NUM
biomedich-710	80	21	:	:	PUNCT
biomedich-710	80	22	unl1	unl1	ADJ
biomedich-710	80	23	:	:	PUNCT
biomedich-710	80	24	h	h	NOUN
biomedich-710	80	25	a	a	DET
biomedich-710	80	26	:	:	PUNCT
biomedich-710	80	27	glu1046	glu1046	NOUN
biomedich-710	80	28	:	:	PUNCT
biomedich-710	80	29	oe1	oe1	PROPN
biomedich-710	80	30	114.214	114.214	NUM
biomedich-710	80	31	:	:	PUNCT
biomedich-710	80	32	unl1	unl1	ADJ
biomedich-710	80	33	:	:	PUNCT
biomedich-710	80	34	h	h	NOUN
biomedich-710	80	35	a	a	DET
biomedich-710	80	36	:	:	PUNCT
biomedich-710	80	37	glu1046	glu1046	NOUN
biomedich-710	80	38	:	:	PUNCT
biomedich-710	80	39	oe1	oe1	PROPN
biomedich-710	80	40	2.12888	2.12888	NUM
biomedich-710	80	41	:	:	PUNCT
biomedich-710	80	42	unl1	unl1	ADJ
biomedich-710	80	43	:	:	PUNCT
biomedich-710	80	44	h	h	NOUN
biomedich-710	80	45	a	a	DET
biomedich-710	80	46	:	:	PUNCT
biomedich-710	80	47	glu1046	glu1046	NOUN
biomedich-710	80	48	:	:	PUNCT
biomedich-710	80	49	oe1	oe1	PROPN
biomedich-710	80	50	137.021	137.021	NUM
biomedich-710	80	51	:	:	PUNCT
biomedich-710	80	52	unl1	unl1	ADJ
biomedich-710	80	53	:	:	PUNCT
biomedich-710	80	54	h	h	NOUN
biomedich-710	80	55	a	a	PRON
biomedich-710	80	56	:	:	PUNCT
biomedich-710	80	57	val1039	val1039	NOUN
biomedich-710	80	58	:o	:o	PROPN
biomedich-710	81	1	2.9988	2.9988	NUM
biomedich-710	81	2	:	:	PUNCT
biomedich-710	81	3	unl1	unl1	ADJ
biomedich-710	81	4	:	:	PUNCT
biomedich-710	81	5	h	h	NOUN
biomedich-710	81	6	a	a	PRON
biomedich-710	81	7	:	:	PUNCT
biomedich-710	81	8	val1039	val1039	NOUN
biomedich-710	81	9	:o	:o	PROPN
biomedich-710	82	1	91.088	91.088	NUM
biomedich-710	82	2	kaempferol	kaempferol	NOUN
biomedich-710	82	3	a	a	DET
biomedich-710	82	4	:	:	PUNCT
biomedich-710	82	5	arg1072	arg1072	NOUN
biomedich-710	82	6	:	:	PUNCT
biomedich-710	82	7	hn	hn	PRON
biomedich-710	82	8	:	:	PUNCT
biomedich-710	82	9	unl1	unl1	PROPN
biomedich-710	82	10	:o	:o	PROPN
biomedich-710	82	11	2.62735	2.62735	NUM
biomedich-710	82	12	a	a	DET
biomedich-710	82	13	:	:	PUNCT
biomedich-710	82	14	arg1072	arg1072	NOUN
biomedich-710	82	15	:	:	PUNCT
biomedich-710	82	16	hn	hn	PRON
biomedich-710	82	17	:	:	PUNCT
biomedich-710	82	18	unl1	unl1	PROPN
biomedich-710	82	19	:o	:o	PUNCT
biomedich-710	82	20	101.889	101.889	NUM
biomedich-710	82	21	a	a	DET
biomedich-710	82	22	:	:	PUNCT
biomedich-710	82	23	gly1073	gly1073	NOUN
biomedich-710	82	24	:	:	PUNCT
biomedich-710	82	25	hn	hn	NOUN
biomedich-710	82	26	:	:	PUNCT
biomedich-710	82	27	unl1	unl1	PROPN
biomedich-710	82	28	:o	:o	PUNCT
biomedich-710	82	29	1.74046	1.74046	NUM
biomedich-710	82	30	a	a	DET
biomedich-710	82	31	:	:	PUNCT
biomedich-710	82	32	gly1073	gly1073	NOUN
biomedich-710	82	33	:	:	PUNCT
biomedich-710	82	34	hn	hn	NOUN
biomedich-710	82	35	:	:	PUNCT
biomedich-710	82	36	unl1	unl1	PROPN
biomedich-710	82	37	:o	:o	PUNCT
biomedich-710	82	38	144.668	144.668	NUM
biomedich-710	82	39	:	:	PUNCT
biomedich-710	82	40	unl1	unl1	ADJ
biomedich-710	82	41	:	:	PUNCT
biomedich-710	82	42	h	h	NOUN
biomedich-710	82	43	a	a	PRON
biomedich-710	82	44	:	:	PUNCT
biomedich-710	82	45	val1039	val1039	NOUN
biomedich-710	82	46	:o	:o	PROPN
biomedich-710	83	1	2.02003	2.02003	NUM
biomedich-710	83	2	:	:	PUNCT
biomedich-710	83	3	unl1	unl1	ADJ
biomedich-710	83	4	:	:	PUNCT
biomedich-710	83	5	h	h	NOUN
biomedich-710	83	6	a	a	PRON
biomedich-710	83	7	:	:	PUNCT
biomedich-710	83	8	val1039	val1039	NOUN
biomedich-710	83	9	:o	:o	PROPN
biomedich-710	83	10	176.714	176.714	NUM
biomedich-710	83	11	:	:	PUNCT
biomedich-710	83	12	unl1	unl1	ADJ
biomedich-710	83	13	:	:	PUNCT
biomedich-710	83	14	h	h	NOUN
biomedich-710	83	15	a	a	DET
biomedich-710	83	16	:	:	PUNCT
biomedich-710	83	17	asp1069	asp1069	NOUN
biomedich-710	83	18	:	:	PUNCT
biomedich-710	83	19	od1	od1	NOUN
biomedich-710	83	20	2.30913	2.30913	NUM
biomedich-710	83	21	:	:	PUNCT
biomedich-710	83	22	unl1	unl1	ADJ
biomedich-710	83	23	:	:	PUNCT
biomedich-710	83	24	h	h	NOUN
biomedich-710	83	25	a	a	DET
biomedich-710	83	26	:	:	PUNCT
biomedich-710	83	27	asp1069	asp1069	NOUN
biomedich-710	83	28	:	:	PUNCT
biomedich-710	83	29	od1	od1	PROPN
biomedich-710	83	30	114.577	114.577	NUM
biomedich-710	83	31	:	:	PUNCT
biomedich-710	83	32	unl1	unl1	ADJ
biomedich-710	83	33	:	:	PUNCT
biomedich-710	83	34	h	h	NOUN
biomedich-710	83	35	a	a	PRON
biomedich-710	83	36	:	:	PUNCT
biomedich-710	83	37	glu1046	glu1046	NOUN
biomedich-710	83	38	:	:	PUNCT
biomedich-710	83	39	oe1	oe1	PROPN
biomedich-710	83	40	2.04473	2.04473	NUM
biomedich-710	83	41	:	:	PUNCT
biomedich-710	83	42	unl1	unl1	ADJ
biomedich-710	83	43	:	:	PUNCT
biomedich-710	83	44	h	h	NOUN
biomedich-710	83	45	a	a	PRON
biomedich-710	83	46	:	:	PUNCT
biomedich-710	83	47	glu1046	glu1046	NOUN
biomedich-710	83	48	:	:	PUNCT
biomedich-710	83	49	oe1	oe1	PROPN
biomedich-710	83	50	167.188	167.188	NUM
biomedich-710	83	51	naringenin	naringenin	NOUN
biomedich-710	83	52	a	a	DET
biomedich-710	83	53	:	:	PUNCT
biomedich-710	83	54	arg1072	arg1072	NOUN
biomedich-710	83	55	:	:	PUNCT
biomedich-710	83	56	hn	hn	PRON
biomedich-710	83	57	:	:	PUNCT
biomedich-710	83	58	unl1	unl1	PROPN
biomedich-710	83	59	:o	:o	PROPN
biomedich-710	83	60	2.89481	2.89481	NUM
biomedich-710	83	61	a	a	DET
biomedich-710	83	62	:	:	PUNCT
biomedich-710	83	63	arg1072	arg1072	NOUN
biomedich-710	83	64	:	:	PUNCT
biomedich-710	83	65	hn	hn	PRON
biomedich-710	83	66	:	:	PUNCT
biomedich-710	83	67	unl1	unl1	PROPN
biomedich-710	83	68	:o	:o	PROPN
biomedich-710	83	69	97.009	97.009	NUM
biomedich-710	83	70	a	a	DET
biomedich-710	83	71	:	:	PUNCT
biomedich-710	83	72	gly1073	gly1073	NOUN
biomedich-710	83	73	:	:	PUNCT
biomedich-710	83	74	hn	hn	NOUN
biomedich-710	83	75	:	:	PUNCT
biomedich-710	83	76	unl1	unl1	PROPN
biomedich-710	83	77	:o	:o	PROPN
biomedich-710	84	1	1.85791	1.85791	NUM
biomedich-710	84	2	a	a	DET
biomedich-710	84	3	:	:	PUNCT
biomedich-710	84	4	gly1073	gly1073	NOUN
biomedich-710	84	5	:	:	PUNCT
biomedich-710	84	6	hn	hn	NOUN
biomedich-710	84	7	:	:	PUNCT
biomedich-710	84	8	unl1	unl1	PROPN
biomedich-710	84	9	:o	:o	PUNCT
biomedich-710	84	10	158.693	158.693	NUM
biomedich-710	84	11	:	:	PUNCT
biomedich-710	84	12	unl1	unl1	ADJ
biomedich-710	84	13	:	:	PUNCT
biomedich-710	84	14	h	h	NOUN
biomedich-710	84	15	a	a	PRON
biomedich-710	84	16	:	:	PUNCT
biomedich-710	84	17	val1039	val1039	NOUN
biomedich-710	84	18	:o	:o	PROPN
biomedich-710	85	1	2.24921	2.24921	NUM
biomedich-710	85	2	:	:	PUNCT
biomedich-710	85	3	unl1	unl1	ADJ
biomedich-710	85	4	:	:	PUNCT
biomedich-710	85	5	h	h	NOUN
biomedich-710	85	6	a	a	PRON
biomedich-710	85	7	:	:	PUNCT
biomedich-710	85	8	val1039	val1039	NOUN
biomedich-710	85	9	:o	:o	PROPN
biomedich-710	85	10	159.885	159.885	NUM
biomedich-710	85	11	:	:	PUNCT
biomedich-710	85	12	unl1	unl1	ADJ
biomedich-710	85	13	:	:	PUNCT
biomedich-710	85	14	h	h	NOUN
biomedich-710	85	15	a	a	DET
biomedich-710	85	16	:	:	PUNCT
biomedich-710	85	17	glu1046	glu1046	NOUN
biomedich-710	85	18	:	:	PUNCT
biomedich-710	85	19	oe1	oe1	PROPN
biomedich-710	85	20	1.87455	1.87455	NUM
biomedich-710	85	21	:	:	PUNCT
biomedich-710	85	22	unl1	unl1	ADJ
biomedich-710	85	23	:	:	PUNCT
biomedich-710	85	24	h	h	NOUN
biomedich-710	85	25	a	a	DET
biomedich-710	85	26	:	:	PUNCT
biomedich-710	85	27	glu1046	glu1046	NOUN
biomedich-710	85	28	:	:	PUNCT
biomedich-710	85	29	oe1	oe1	PROPN
biomedich-710	85	30	135.297	135.297	NUM
biomedich-710	85	31	d	d	NOUN
biomedich-710	85	32	e	e	X
biomedich-710	85	33	f	f	PROPN
biomedich-710	85	34	h	h	NOUN
biomedich-710	85	35	ig	ig	PROPN
biomedich-710	85	36	isuranga	isuranga	NOUN
biomedich-710	85	37	&	&	CCONJ
biomedich-710	85	38	danthanarayana	danthanarayana	PROPN
biomedich-710	85	39	–	–	PUNCT
biomedich-710	85	40	antimicrobial	antimicrobial	ADJ
biomedich-710	85	41	potential	potential	NOUN
biomedich-710	85	42	of	of	ADP
biomedich-710	85	43	phytochemicals	phytochemical	NOUN
biomedich-710	85	44	from	from	ADP
biomedich-710	85	45	coccinia	coccinia	NOUN
biomedich-710	85	46	grandis	grandis	NOUN
biomedich-710	85	47	…	…	PUNCT
biomedich-710	85	48	547	547	NUM
biomedich-710	85	49	table	table	NOUN
biomedich-710	85	50	6	6	NUM
biomedich-710	85	51	.	.	PUNCT
biomedich-710	86	1	cont	cont	NOUN
biomedich-710	86	2	.	.	PUNCT
biomedich-710	87	1	molecule	molecule	NOUN
biomedich-710	87	2	name	name	NOUN
biomedich-710	87	3	distance	distance	NOUN
biomedich-710	87	4	(	(	PUNCT
biomedich-710	87	5	a0	a0	NOUN
biomedich-710	87	6	)	)	PUNCT
biomedich-710	87	7	h	h	NOUN
biomedich-710	87	8	-	-	PUNCT
biomedich-710	87	9	donor	donor	NOUN
biomedich-710	87	10	h	h	NOUN
biomedich-710	87	11	-	-	PUNCT
biomedich-710	87	12	acceptor	acceptor	NOUN
biomedich-710	87	13	dha	dha	PROPN
biomedich-710	87	14	angle	angle	NOUN
biomedich-710	87	15	(	(	PUNCT
biomedich-710	87	16	0	0	NUM
biomedich-710	87	17	)	)	PUNCT
biomedich-710	87	18	isoquercetin	isoquercetin	NOUN
biomedich-710	87	19	a	a	DET
biomedich-710	87	20	:	:	PUNCT
biomedich-710	87	21	asn1042	asn1042	NOUN
biomedich-710	87	22	:	:	PUNCT
biomedich-710	87	23	hd21	hd21	PROPN
biomedich-710	87	24	:	:	PUNCT
biomedich-710	87	25	unl1	unl1	PROPN
biomedich-710	87	26	:o	:o	PUNCT
biomedich-710	87	27	2.7382	2.7382	NUM
biomedich-710	87	28	a	a	DET
biomedich-710	87	29	:	:	PUNCT
biomedich-710	87	30	asn1042	asn1042	NOUN
biomedich-710	87	31	:	:	PUNCT
biomedich-710	87	32	hd21	hd21	PROPN
biomedich-710	87	33	:	:	PUNCT
biomedich-710	87	34	unl1	unl1	PROPN
biomedich-710	87	35	:o	:o	PROPN
biomedich-710	88	1	100.17	100.17	NUM
biomedich-710	88	2	a	a	DET
biomedich-710	88	3	:	:	PUNCT
biomedich-710	88	4	asn1042	asn1042	NOUN
biomedich-710	88	5	:	:	PUNCT
biomedich-710	88	6	hd21	hd21	PROPN
biomedich-710	88	7	:	:	PUNCT
biomedich-710	88	8	unl1	unl1	PROPN
biomedich-710	88	9	:o	:o	PUNCT
biomedich-710	88	10	1.92763	1.92763	NUM
biomedich-710	88	11	a	a	DET
biomedich-710	88	12	:	:	PUNCT
biomedich-710	88	13	asn1042	asn1042	NOUN
biomedich-710	88	14	:	:	PUNCT
biomedich-710	88	15	hd21	hd21	PROPN
biomedich-710	88	16	:	:	PUNCT
biomedich-710	88	17	unl1	unl1	PROPN
biomedich-710	88	18	:o	:o	PROPN
biomedich-710	88	19	164.831	164.831	NUM
biomedich-710	88	20	a	a	DET
biomedich-710	88	21	:	:	PUNCT
biomedich-710	88	22	gly1073	gly1073	NOUN
biomedich-710	88	23	:	:	PUNCT
biomedich-710	88	24	hn	hn	NOUN
biomedich-710	88	25	:	:	PUNCT
biomedich-710	88	26	unl1	unl1	PROPN
biomedich-710	88	27	:o	:o	PUNCT
biomedich-710	88	28	1.67752	1.67752	NUM
biomedich-710	88	29	a	a	DET
biomedich-710	88	30	:	:	PUNCT
biomedich-710	88	31	gly1073	gly1073	NOUN
biomedich-710	88	32	:	:	PUNCT
biomedich-710	88	33	hn	hn	NOUN
biomedich-710	88	34	:	:	PUNCT
biomedich-710	88	35	unl1	unl1	PROPN
biomedich-710	88	36	:o	:o	PUNCT
biomedich-710	88	37	141.974	141.974	NUM
biomedich-710	88	38	:	:	PUNCT
biomedich-710	88	39	unl1	unl1	ADJ
biomedich-710	88	40	:	:	PUNCT
biomedich-710	88	41	h	h	NOUN
biomedich-710	88	42	a	a	DET
biomedich-710	88	43	:	:	PUNCT
biomedich-710	88	44	asn1042	asn1042	NOUN
biomedich-710	88	45	:o	:o	PROPN
biomedich-710	89	1	2.23832	2.23832	NUM
biomedich-710	89	2	:	:	PUNCT
biomedich-710	89	3	unl1	unl1	ADJ
biomedich-710	89	4	:	:	PUNCT
biomedich-710	89	5	h	h	NOUN
biomedich-710	89	6	a	a	PRON
biomedich-710	89	7	:	:	PUNCT
biomedich-710	89	8	asn1042	asn1042	NOUN
biomedich-710	89	9	:o	:o	PROPN
biomedich-710	89	10	102.23	102.23	NUM
biomedich-710	89	11	:	:	PUNCT
biomedich-710	89	12	unl1	unl1	ADJ
biomedich-710	89	13	:	:	PUNCT
biomedich-710	89	14	h	h	NOUN
biomedich-710	89	15	a	a	DET
biomedich-710	89	16	:	:	PUNCT
biomedich-710	89	17	glu1046	glu1046	NOUN
biomedich-710	89	18	:	:	PUNCT
biomedich-710	89	19	oe1	oe1	PROPN
biomedich-710	89	20	1.86696	1.86696	NUM
biomedich-710	89	21	:	:	PUNCT
biomedich-710	89	22	unl1	unl1	ADJ
biomedich-710	89	23	:	:	PUNCT
biomedich-710	89	24	h	h	NOUN
biomedich-710	89	25	a	a	DET
biomedich-710	89	26	:	:	PUNCT
biomedich-710	89	27	glu1046	glu1046	NOUN
biomedich-710	89	28	:	:	PUNCT
biomedich-710	89	29	oe1	oe1	PROPN
biomedich-710	89	30	133.412	133.412	NUM
biomedich-710	89	31	:	:	PUNCT
biomedich-710	89	32	unl1	unl1	ADJ
biomedich-710	89	33	:	:	PUNCT
biomedich-710	89	34	h	h	NOUN
biomedich-710	89	35	a	a	DET
biomedich-710	89	36	:	:	PUNCT
biomedich-710	89	37	glu1046	glu1046	NOUN
biomedich-710	89	38	:	:	PUNCT
biomedich-710	89	39	oe1	oe1	PROPN
biomedich-710	90	1	2.33954	2.33954	NUM
biomedich-710	90	2	:	:	PUNCT
biomedich-710	90	3	unl1	unl1	ADJ
biomedich-710	90	4	:	:	PUNCT
biomedich-710	90	5	h	h	NOUN
biomedich-710	90	6	a	a	DET
biomedich-710	90	7	:	:	PUNCT
biomedich-710	90	8	glu1046	glu1046	NOUN
biomedich-710	90	9	:	:	PUNCT
biomedich-710	90	10	oe1	oe1	NOUN
biomedich-710	90	11	128.18	128.18	NUM
biomedich-710	90	12	:	:	PUNCT
biomedich-710	90	13	unl1	unl1	ADJ
biomedich-710	90	14	:	:	PUNCT
biomedich-710	90	15	h	h	NOUN
biomedich-710	91	1	a	a	PRON
biomedich-710	91	2	:	:	PUNCT
biomedich-710	91	3	val1039	val1039	NOUN
biomedich-710	91	4	:o	:o	PROPN
biomedich-710	92	1	2.95873	2.95873	NUM
biomedich-710	92	2	:	:	PUNCT
biomedich-710	92	3	unl1	unl1	ADJ
biomedich-710	92	4	:	:	PUNCT
biomedich-710	92	5	h	h	NOUN
biomedich-710	92	6	a	a	PRON
biomedich-710	92	7	:	:	PUNCT
biomedich-710	92	8	val1039	val1039	NOUN
biomedich-710	92	9	:o	:o	PROPN
biomedich-710	92	10	103.791	103.791	NUM
biomedich-710	92	11	table	table	NOUN
biomedich-710	92	12	7	7	NUM
biomedich-710	92	13	.	.	PUNCT
biomedich-710	92	14	hydrogen	hydrogen	NOUN
biomedich-710	92	15	bonding	bonding	NOUN
biomedich-710	92	16	interactions	interaction	NOUN
biomedich-710	92	17	(	(	PUNCT
biomedich-710	92	18	intermolecular	intermolecular	ADJ
biomedich-710	92	19	conventional	conventional	ADJ
biomedich-710	92	20	hydrogen	hydrogen	NOUN
biomedich-710	92	21	bond	bond	NOUN
biomedich-710	92	22	)	)	PUNCT
biomedich-710	92	23	between	between	ADP
biomedich-710	92	24	ligands	ligand	NOUN
biomedich-710	92	25	and	and	CCONJ
biomedich-710	92	26	topoisomerase	topoisomerase	NOUN
biomedich-710	92	27	iv	iv	NUM
biomedich-710	92	28	pare	pare	NOUN
biomedich-710	92	29	24kda	24kda	NOUN
biomedich-710	92	30	subunit	subunit	NOUN
biomedich-710	92	31	of	of	ADP
biomedich-710	92	32	s.	s.	PROPN
biomedich-710	92	33	aureus	aureus	PROPN
biomedich-710	92	34	.	.	PUNCT
biomedich-710	93	1	molecule	molecule	NOUN
biomedich-710	93	2	name	name	NOUN
biomedich-710	93	3	distance	distance	NOUN
biomedich-710	93	4	(	(	PUNCT
biomedich-710	93	5	a0	a0	NOUN
biomedich-710	93	6	)	)	PUNCT
biomedich-710	93	7	h	h	NOUN
biomedich-710	93	8	-	-	PUNCT
biomedich-710	93	9	donor	donor	NOUN
biomedich-710	93	10	h	h	NOUN
biomedich-710	93	11	-	-	PUNCT
biomedich-710	93	12	acceptor	acceptor	NOUN
biomedich-710	93	13	dha	dha	PROPN
biomedich-710	93	14	angle	angle	NOUN
biomedich-710	93	15	(	(	PUNCT
biomedich-710	93	16	0	0	NUM
biomedich-710	93	17	)	)	PUNCT
biomedich-710	93	18	novobiocin	novobiocin	PART
biomedich-710	93	19	a	a	DET
biomedich-710	93	20	:	:	PUNCT
biomedich-710	93	21	arg138	arg138	PROPN
biomedich-710	93	22	:	:	PUNCT
biomedich-710	93	23	hh11	hh11	PROPN
biomedich-710	93	24	:	:	PUNCT
biomedich-710	93	25	unl1	unl1	PROPN
biomedich-710	93	26	:o	:o	PROPN
biomedich-710	93	27	2.07271	2.07271	NUM
biomedich-710	93	28	a	a	DET
biomedich-710	93	29	:	:	PUNCT
biomedich-710	93	30	arg138	arg138	PROPN
biomedich-710	93	31	:	:	PUNCT
biomedich-710	93	32	hh11	hh11	PROPN
biomedich-710	93	33	:	:	PUNCT
biomedich-710	93	34	unl1	unl1	PROPN
biomedich-710	93	35	:o	:o	PROPN
biomedich-710	94	1	116.16	116.16	NUM
biomedich-710	94	2	:	:	PUNCT
biomedich-710	94	3	unl1	unl1	ADJ
biomedich-710	94	4	:	:	PUNCT
biomedich-710	94	5	h	h	NOUN
biomedich-710	94	6	a	a	DET
biomedich-710	94	7	:	:	PUNCT
biomedich-710	94	8	thr92	thr92	NOUN
biomedich-710	94	9	:	:	PUNCT
biomedich-710	94	10	og1	og1	NOUN
biomedich-710	94	11	2.30294	2.30294	NUM
biomedich-710	94	12	:	:	PUNCT
biomedich-710	94	13	unl1	unl1	ADJ
biomedich-710	94	14	:	:	PUNCT
biomedich-710	94	15	h	h	NOUN
biomedich-710	94	16	a	a	DET
biomedich-710	94	17	:	:	PUNCT
biomedich-710	94	18	thr92	thr92	NOUN
biomedich-710	94	19	:	:	PUNCT
biomedich-710	94	20	og1	og1	NOUN
biomedich-710	94	21	142.972	142.972	NUM
biomedich-710	94	22	:	:	PUNCT
biomedich-710	94	23	unl1	unl1	PROPN
biomedich-710	94	24	:	:	PUNCT
biomedich-710	94	25	h	h	NOUN
biomedich-710	94	26	a	a	PRON
biomedich-710	94	27	:	:	PUNCT
biomedich-710	94	28	gly80	gly80	VERB
biomedich-710	94	29	:o	:o	NOUN
biomedich-710	94	30	2.37333	2.37333	NUM
biomedich-710	94	31	:	:	PUNCT
biomedich-710	94	32	unl1	unl1	ADJ
biomedich-710	94	33	:	:	PUNCT
biomedich-710	94	34	h	h	NOUN
biomedich-710	94	35	a	a	PRON
biomedich-710	94	36	:	:	PUNCT
biomedich-710	94	37	gly80	gly80	VERB
biomedich-710	94	38	:o	:o	PRON
biomedich-710	94	39	114.849	114.849	NUM
biomedich-710	94	40	:	:	PUNCT
biomedich-710	94	41	unl1	unl1	ADJ
biomedich-710	94	42	:	:	PUNCT
biomedich-710	94	43	h	h	NOUN
biomedich-710	95	1	a	a	PRON
biomedich-710	95	2	:	:	PUNCT
biomedich-710	95	3	glu53	glu53	NOUN
biomedich-710	95	4	:	:	PUNCT
biomedich-710	95	5	oe1	oe1	PROPN
biomedich-710	95	6	2.28073	2.28073	NUM
biomedich-710	95	7	:	:	PUNCT
biomedich-710	95	8	unl1	unl1	ADJ
biomedich-710	95	9	:	:	PUNCT
biomedich-710	95	10	h	h	NOUN
biomedich-710	96	1	a	a	PRON
biomedich-710	96	2	:	:	PUNCT
biomedich-710	96	3	glu53	glu53	NOUN
biomedich-710	96	4	:	:	PUNCT
biomedich-710	96	5	oe1	oe1	PROPN
biomedich-710	96	6	153.157	153.157	NUM
biomedich-710	96	7	:	:	PUNCT
biomedich-710	96	8	unl1	unl1	ADJ
biomedich-710	96	9	:	:	PUNCT
biomedich-710	96	10	h	h	NOUN
biomedich-710	96	11	a	a	DET
biomedich-710	96	12	:	:	PUNCT
biomedich-710	96	13	asp76	asp76	NOUN
biomedich-710	96	14	:	:	PUNCT
biomedich-710	96	15	od2	od2	NOUN
biomedich-710	96	16	1.84227	1.84227	NUM
biomedich-710	96	17	:	:	PUNCT
biomedich-710	96	18	unl1	unl1	ADJ
biomedich-710	96	19	:	:	PUNCT
biomedich-710	96	20	h	h	NOUN
biomedich-710	96	21	a	a	DET
biomedich-710	96	22	:	:	PUNCT
biomedich-710	96	23	asp76	asp76	NOUN
biomedich-710	96	24	:	:	PUNCT
biomedich-710	96	25	od2	od2	NOUN
biomedich-710	96	26	129.527	129.527	NUM
biomedich-710	96	27	quercetin	quercetin	NOUN
biomedich-710	96	28	a	a	DET
biomedich-710	96	29	:	:	PUNCT
biomedich-710	96	30	arg79	arg79	NOUN
biomedich-710	96	31	:	:	PUNCT
biomedich-710	96	32	hn	hn	PROPN
biomedich-710	96	33	:	:	PUNCT
biomedich-710	96	34	unl1	unl1	PROPN
biomedich-710	96	35	:o	:o	PROPN
biomedich-710	96	36	2.74275	2.74275	NUM
biomedich-710	96	37	a	a	DET
biomedich-710	96	38	:	:	PUNCT
biomedich-710	96	39	arg79	arg79	NOUN
biomedich-710	96	40	:	:	PUNCT
biomedich-710	96	41	hn	hn	PROPN
biomedich-710	96	42	:	:	PUNCT
biomedich-710	97	1	unl1	unl1	PROPN
biomedich-710	97	2	:o	:o	PROPN
biomedich-710	97	3	97.988	97.988	NUM
biomedich-710	97	4	a	a	DET
biomedich-710	97	5	:	:	PUNCT
biomedich-710	97	6	gly80	gly80	NOUN
biomedich-710	97	7	:	:	PUNCT
biomedich-710	97	8	hn	hn	PROPN
biomedich-710	97	9	:	:	PUNCT
biomedich-710	97	10	unl1	unl1	PROPN
biomedich-710	97	11	:o	:o	PROPN
biomedich-710	97	12	1.68791	1.68791	NUM
biomedich-710	97	13	a	a	PRON
biomedich-710	97	14	:	:	PUNCT
biomedich-710	97	15	gly80	gly80	NOUN
biomedich-710	97	16	:	:	PUNCT
biomedich-710	97	17	hn	hn	PROPN
biomedich-710	97	18	:	:	PUNCT
biomedich-710	97	19	unl1	unl1	PROPN
biomedich-710	97	20	:o	:o	PROPN
biomedich-710	98	1	145.046	145.046	NUM
biomedich-710	98	2	:	:	PUNCT
biomedich-710	98	3	unl1	unl1	ADJ
biomedich-710	98	4	:	:	PUNCT
biomedich-710	98	5	h	h	NOUN
biomedich-710	98	6	a	a	DET
biomedich-710	98	7	:	:	PUNCT
biomedich-710	98	8	ile46	ile46	NOUN
biomedich-710	98	9	:o	:o	NOUN
biomedich-710	99	1	2.13321	2.13321	NUM
biomedich-710	99	2	:	:	PUNCT
biomedich-710	99	3	unl1	unl1	ADJ
biomedich-710	99	4	:	:	PUNCT
biomedich-710	99	5	h	h	NOUN
biomedich-710	99	6	a	a	DET
biomedich-710	99	7	:	:	PUNCT
biomedich-710	99	8	ile46	ile46	NOUN
biomedich-710	99	9	:o	:o	PROPN
biomedich-710	99	10	152.776	152.776	NUM
biomedich-710	99	11	:	:	PUNCT
biomedich-710	99	12	unl1	unl1	ADJ
biomedich-710	99	13	:	:	PUNCT
biomedich-710	99	14	h	h	NOUN
biomedich-710	99	15	a	a	DET
biomedich-710	99	16	:	:	PUNCT
biomedich-710	99	17	asp76	asp76	ADJ
biomedich-710	99	18	:	:	PUNCT
biomedich-710	99	19	od1	od1	NOUN
biomedich-710	99	20	2.27165	2.27165	NUM
biomedich-710	99	21	:	:	PUNCT
biomedich-710	99	22	unl1	unl1	ADJ
biomedich-710	99	23	:	:	PUNCT
biomedich-710	99	24	h	h	NOUN
biomedich-710	99	25	a	a	DET
biomedich-710	99	26	:	:	PUNCT
biomedich-710	99	27	asp76	asp76	ADJ
biomedich-710	99	28	:	:	PUNCT
biomedich-710	99	29	od1	od1	NOUN
biomedich-710	99	30	112.554	112.554	NUM
biomedich-710	99	31	:	:	PUNCT
biomedich-710	99	32	unl1	unl1	ADJ
biomedich-710	99	33	:	:	PUNCT
biomedich-710	99	34	h	h	NOUN
biomedich-710	99	35	a	a	DET
biomedich-710	99	36	:	:	PUNCT
biomedich-710	99	37	glu53	glu53	NOUN
biomedich-710	99	38	:	:	PUNCT
biomedich-710	99	39	oe2	oe2	PROPN
biomedich-710	99	40	1.92621	1.92621	NUM
biomedich-710	99	41	:	:	PUNCT
biomedich-710	99	42	unl1	unl1	ADJ
biomedich-710	99	43	:	:	PUNCT
biomedich-710	99	44	h	h	NOUN
biomedich-710	99	45	a	a	PRON
biomedich-710	99	46	:	:	PUNCT
biomedich-710	99	47	glu53	glu53	NOUN
biomedich-710	99	48	:	:	PUNCT
biomedich-710	99	49	oe2	oe2	PROPN
biomedich-710	99	50	122.031	122.031	NUM
biomedich-710	99	51	kaempferol	kaempferol	NOUN
biomedich-710	99	52	:	:	PUNCT
biomedich-710	99	53	unl1	unl1	ADJ
biomedich-710	99	54	:	:	PUNCT
biomedich-710	99	55	h	h	NOUN
biomedich-710	99	56	a	a	PRON
biomedich-710	99	57	:	:	PUNCT
biomedich-710	99	58	ser50	ser50	VERB
biomedich-710	99	59	:	:	PUNCT
biomedich-710	99	60	og	og	PROPN
biomedich-710	99	61	2.19725	2.19725	NUM
biomedich-710	99	62	:	:	PUNCT
biomedich-710	99	63	unl1	unl1	ADJ
biomedich-710	99	64	:	:	PUNCT
biomedich-710	99	65	h	h	NOUN
biomedich-710	99	66	a	a	PRON
biomedich-710	99	67	:	:	PUNCT
biomedich-710	99	68	ser50	ser50	VERB
biomedich-710	99	69	:	:	PUNCT
biomedich-710	99	70	og	og	PROPN
biomedich-710	99	71	150.997	150.997	NUM
biomedich-710	99	72	:	:	PUNCT
biomedich-710	99	73	unl1	unl1	ADJ
biomedich-710	99	74	:	:	PUNCT
biomedich-710	99	75	h	h	NOUN
biomedich-710	99	76	a	a	DET
biomedich-710	99	77	:	:	PUNCT
biomedich-710	99	78	asn49	asn49	ADJ
biomedich-710	99	79	:o	:o	NOUN
biomedich-710	100	1	1.75646	1.75646	NUM
biomedich-710	100	2	:	:	PUNCT
biomedich-710	100	3	unl1	unl1	ADJ
biomedich-710	100	4	:	:	PUNCT
biomedich-710	100	5	h	h	NOUN
biomedich-710	100	6	a	a	DET
biomedich-710	100	7	:	:	PUNCT
biomedich-710	100	8	asn49	asn49	ADJ
biomedich-710	100	9	:o	:o	PROPN
biomedich-710	100	10	133.732	133.732	NUM
biomedich-710	100	11	:	:	PUNCT
biomedich-710	100	12	unl1	unl1	ADJ
biomedich-710	100	13	:	:	PUNCT
biomedich-710	100	14	h	h	NOUN
biomedich-710	100	15	a	a	DET
biomedich-710	100	16	:	:	PUNCT
biomedich-710	100	17	asn56	asn56	NOUN
biomedich-710	100	18	:	:	PUNCT
biomedich-710	100	19	od1	od1	NOUN
biomedich-710	100	20	1.98098	1.98098	NUM
biomedich-710	100	21	:	:	PUNCT
biomedich-710	100	22	unl1	unl1	ADJ
biomedich-710	100	23	:	:	PUNCT
biomedich-710	100	24	h	h	NOUN
biomedich-710	100	25	a	a	DET
biomedich-710	100	26	:	:	PUNCT
biomedich-710	100	27	asn56	asn56	NOUN
biomedich-710	100	28	:	:	PUNCT
biomedich-710	100	29	od1	od1	NOUN
biomedich-710	100	30	144.601	144.601	NUM
biomedich-710	100	31	:	:	PUNCT
biomedich-710	100	32	unl1	unl1	ADJ
biomedich-710	100	33	:	:	PUNCT
biomedich-710	100	34	h	h	NOUN
biomedich-710	100	35	a	a	PRON
biomedich-710	100	36	:	:	PUNCT
biomedich-710	100	37	gly80	gly80	VERB
biomedich-710	100	38	:o	:o	PRON
biomedich-710	100	39	2.00352	2.00352	NUM
biomedich-710	100	40	:	:	PUNCT
biomedich-710	100	41	unl1	unl1	ADJ
biomedich-710	100	42	:	:	PUNCT
biomedich-710	100	43	h	h	NOUN
biomedich-710	100	44	a	a	PRON
biomedich-710	100	45	:	:	PUNCT
biomedich-710	100	46	gly80	gly80	VERB
biomedich-710	100	47	:o	:o	PROPN
biomedich-710	100	48	143.187	143.187	NUM
biomedich-710	100	49	naringenin	naringenin	NOUN
biomedich-710	100	50	:	:	PUNCT
biomedich-710	100	51	unl1	unl1	ADJ
biomedich-710	100	52	:	:	PUNCT
biomedich-710	100	53	h	h	NOUN
biomedich-710	100	54	a	a	PRON
biomedich-710	100	55	:	:	PUNCT
biomedich-710	100	56	gly80	gly80	VERB
biomedich-710	100	57	:o	:o	NOUN
biomedich-710	100	58	2.08123	2.08123	NUM
biomedich-710	100	59	:	:	PUNCT
biomedich-710	100	60	unl1	unl1	ADJ
biomedich-710	100	61	:	:	PUNCT
biomedich-710	100	62	h	h	NOUN
biomedich-710	100	63	a	a	PRON
biomedich-710	100	64	:	:	PUNCT
biomedich-710	100	65	gly80	gly80	VERB
biomedich-710	100	66	:o	:o	PRON
biomedich-710	100	67	138.264	138.264	NUM
biomedich-710	100	68	:	:	PUNCT
biomedich-710	100	69	unl1	unl1	ADJ
biomedich-710	100	70	:	:	PUNCT
biomedich-710	100	71	h	h	NOUN
biomedich-710	100	72	a	a	DET
biomedich-710	100	73	:	:	PUNCT
biomedich-710	100	74	asp76	asp76	NOUN
biomedich-710	100	75	:	:	PUNCT
biomedich-710	100	76	od2	od2	NOUN
biomedich-710	100	77	2.21723	2.21723	NUM
biomedich-710	100	78	:	:	PUNCT
biomedich-710	100	79	unl1	unl1	ADJ
biomedich-710	100	80	:	:	PUNCT
biomedich-710	100	81	h	h	NOUN
biomedich-710	100	82	a	a	DET
biomedich-710	100	83	:	:	PUNCT
biomedich-710	100	84	asp76	asp76	NOUN
biomedich-710	100	85	:	:	PUNCT
biomedich-710	100	86	od2	od2	NOUN
biomedich-710	100	87	145.165	145.165	NUM
biomedich-710	100	88	:	:	PUNCT
biomedich-710	100	89	unl1	unl1	ADJ
biomedich-710	100	90	:	:	PUNCT
biomedich-710	100	91	h	h	NOUN
biomedich-710	100	92	a	a	DET
biomedich-710	100	93	:	:	PUNCT
biomedich-710	100	94	thr168	thr168	ADP
biomedich-710	100	95	:o	:o	PROPN
biomedich-710	100	96	2.91224	2.91224	NUM
biomedich-710	100	97	:	:	PUNCT
biomedich-710	100	98	unl1	unl1	ADJ
biomedich-710	100	99	:	:	PUNCT
biomedich-710	100	100	h	h	NOUN
biomedich-710	100	101	a	a	DET
biomedich-710	100	102	:	:	PUNCT
biomedich-710	100	103	thr168	thr168	PROPN
biomedich-710	100	104	:o	:o	PROPN
biomedich-710	100	105	111.039	111.039	NUM
biomedich-710	100	106	isoquercetin	isoquercetin	NOUN
biomedich-710	100	107	a	a	DET
biomedich-710	100	108	:	:	PUNCT
biomedich-710	100	109	asn49	asn49	ADJ
biomedich-710	100	110	:	:	PUNCT
biomedich-710	100	111	hd21	hd21	PROPN
biomedich-710	100	112	:	:	PUNCT
biomedich-710	100	113	unl1	unl1	PROPN
biomedich-710	100	114	:o	:o	PUNCT
biomedich-710	100	115	2.8621	2.8621	NUM
biomedich-710	100	116	a	a	DET
biomedich-710	100	117	:	:	PUNCT
biomedich-710	100	118	asn49	asn49	ADJ
biomedich-710	100	119	:	:	PUNCT
biomedich-710	100	120	hd21	hd21	PROPN
biomedich-710	100	121	:	:	PUNCT
biomedich-710	100	122	unl1	unl1	PROPN
biomedich-710	100	123	:o	:o	PUNCT
biomedich-710	100	124	119.408	119.408	NUM
biomedich-710	100	125	:	:	PUNCT
biomedich-710	100	126	unl1	unl1	ADJ
biomedich-710	100	127	:	:	PUNCT
biomedich-710	100	128	h	h	NOUN
biomedich-710	100	129	a	a	DET
biomedich-710	100	130	:	:	PUNCT
biomedich-710	100	131	asn56	asn56	NOUN
biomedich-710	100	132	:	:	PUNCT
biomedich-710	100	133	od1	od1	NOUN
biomedich-710	100	134	2.05503	2.05503	NUM
biomedich-710	100	135	:	:	PUNCT
biomedich-710	100	136	unl1	unl1	ADJ
biomedich-710	100	137	:	:	PUNCT
biomedich-710	100	138	h	h	NOUN
biomedich-710	100	139	a	a	DET
biomedich-710	100	140	:	:	PUNCT
biomedich-710	100	141	asn56	asn56	NOUN
biomedich-710	100	142	:	:	PUNCT
biomedich-710	100	143	od1	od1	NOUN
biomedich-710	100	144	155.619	155.619	NUM
biomedich-710	100	145	:	:	PUNCT
biomedich-710	100	146	unl1	unl1	ADJ
biomedich-710	100	147	:	:	PUNCT
biomedich-710	100	148	h	h	NOUN
biomedich-710	100	149	a	a	PRON
biomedich-710	100	150	:	:	PUNCT
biomedich-710	100	151	glu53	glu53	NOUN
biomedich-710	100	152	:	:	PUNCT
biomedich-710	100	153	oe1	oe1	NOUN
biomedich-710	100	154	1.71719	1.71719	NUM
biomedich-710	100	155	:	:	PUNCT
biomedich-710	100	156	unl1	unl1	ADJ
biomedich-710	100	157	:	:	PUNCT
biomedich-710	100	158	h	h	NOUN
biomedich-710	101	1	a	a	PRON
biomedich-710	101	2	:	:	PUNCT
biomedich-710	101	3	glu53	glu53	NOUN
biomedich-710	101	4	:	:	PUNCT
biomedich-710	101	5	oe1	oe1	PROPN
biomedich-710	101	6	133.802	133.802	NUM
biomedich-710	101	7	:	:	PUNCT
biomedich-710	101	8	unl1	unl1	ADJ
biomedich-710	101	9	:	:	PUNCT
biomedich-710	101	10	h	h	NOUN
biomedich-710	101	11	a	a	DET
biomedich-710	101	12	:	:	PUNCT
biomedich-710	101	13	asn56	asn56	NOUN
biomedich-710	101	14	:	:	PUNCT
biomedich-710	101	15	od1	od1	NOUN
biomedich-710	101	16	2.06169	2.06169	NUM
biomedich-710	101	17	:	:	PUNCT
biomedich-710	101	18	unl1	unl1	ADJ
biomedich-710	101	19	:	:	PUNCT
biomedich-710	101	20	h	h	NOUN
biomedich-710	101	21	a	a	DET
biomedich-710	101	22	:	:	PUNCT
biomedich-710	101	23	asn56	asn56	NOUN
biomedich-710	101	24	:	:	PUNCT
biomedich-710	101	25	od1	od1	NOUN
biomedich-710	101	26	97.614	97.614	NUM
biomedich-710	101	27	:	:	PUNCT
biomedich-710	101	28	unl1	unl1	ADJ
biomedich-710	101	29	:	:	PUNCT
biomedich-710	101	30	h	h	NOUN
biomedich-710	101	31	a	a	PRON
biomedich-710	101	32	:	:	PUNCT
biomedich-710	101	33	glu53	glu53	NOUN
biomedich-710	101	34	:	:	PUNCT
biomedich-710	101	35	oe1	oe1	PROPN
biomedich-710	101	36	2.16274	2.16274	NUM
biomedich-710	101	37	:	:	PUNCT
biomedich-710	101	38	unl1	unl1	ADJ
biomedich-710	101	39	:	:	PUNCT
biomedich-710	101	40	h	h	NOUN
biomedich-710	101	41	a	a	PRON
biomedich-710	101	42	:	:	PUNCT
biomedich-710	101	43	glu53	glu53	NOUN
biomedich-710	101	44	:	:	PUNCT
biomedich-710	101	45	oe1	oe1	PROPN
biomedich-710	101	46	107.551	107.551	NUM
biomedich-710	101	47	:	:	PUNCT
biomedich-710	101	48	unl1	unl1	ADJ
biomedich-710	101	49	:	:	PUNCT
biomedich-710	101	50	h	h	NOUN
biomedich-710	101	51	a	a	DET
biomedich-710	101	52	:	:	PUNCT
biomedich-710	101	53	asp76	asp76	NOUN
biomedich-710	101	54	:	:	PUNCT
biomedich-710	101	55	od2	od2	NOUN
biomedich-710	101	56	2.11531	2.11531	NUM
biomedich-710	101	57	:	:	PUNCT
biomedich-710	101	58	unl1	unl1	ADJ
biomedich-710	101	59	:	:	PUNCT
biomedich-710	101	60	h	h	NOUN
biomedich-710	101	61	a	a	DET
biomedich-710	101	62	:	:	PUNCT
biomedich-710	101	63	asp76	asp76	ADJ
biomedich-710	101	64	:	:	PUNCT
biomedich-710	101	65	od2	od2	NOUN
biomedich-710	101	66	141.204	141.204	NUM
biomedich-710	101	67	sanguinarine	sanguinarine	NOUN
biomedich-710	101	68	a	a	DET
biomedich-710	101	69	:	:	PUNCT
biomedich-710	101	70	arg79	arg79	NOUN
biomedich-710	101	71	:	:	PUNCT
biomedich-710	101	72	he	he	PRON
biomedich-710	101	73	:	:	PUNCT
biomedich-710	101	74	unl1	unl1	PROPN
biomedich-710	101	75	:o	:o	PROPN
biomedich-710	102	1	2.65739	2.65739	NUM
biomedich-710	102	2	a	a	DET
biomedich-710	102	3	:	:	PUNCT
biomedich-710	102	4	arg79	arg79	NOUN
biomedich-710	102	5	:	:	PUNCT
biomedich-710	102	6	he	he	PRON
biomedich-710	102	7	:	:	PUNCT
biomedich-710	103	1	unl1	unl1	PROPN
biomedich-710	103	2	:o	:o	PROPN
biomedich-710	103	3	90.653	90.653	NUM
biomedich-710	103	4	table	table	NOUN
biomedich-710	103	5	8	8	NUM
biomedich-710	103	6	.	.	PUNCT
biomedich-710	103	7	predicted	predict	VERB
biomedich-710	103	8	physiochemical	physiochemical	ADJ
biomedich-710	103	9	properties	property	NOUN
biomedich-710	103	10	of	of	ADP
biomedich-710	103	11	selected	select	VERB
biomedich-710	103	12	molecules	molecule	NOUN
biomedich-710	103	13	(	(	PUNCT
biomedich-710	103	14	mw	mw	NOUN
biomedich-710	103	15	=	=	PUNCT
biomedich-710	103	16	molecular	molecular	ADJ
biomedich-710	103	17	weight	weight	NOUN
biomedich-710	103	18	,	,	PUNCT
biomedich-710	103	19	nha	nha	X
biomedich-710	103	20	=	=	SYM
biomedich-710	103	21	number	number	NOUN
biomedich-710	103	22	of	of	ADP
biomedich-710	103	23	heavy	heavy	ADJ
biomedich-710	103	24	atoms	atom	NOUN
biomedich-710	103	25	,	,	PUNCT
biomedich-710	103	26	nrb	nrb	NOUN
biomedich-710	103	27	=	=	PUNCT
biomedich-710	103	28	number	number	NOUN
biomedich-710	103	29	of	of	ADP
biomedich-710	103	30	rotatable	rotatable	ADJ
biomedich-710	103	31	bonds	bond	NOUN
biomedich-710	103	32	,	,	PUNCT
biomedich-710	103	33	nhba	nhba	ADJ
biomedich-710	103	34	=	=	NOUN
biomedich-710	103	35	number	number	NOUN
biomedich-710	103	36	of	of	ADP
biomedich-710	103	37	h	h	NOUN
biomedich-710	103	38	-	-	PUNCT
biomedich-710	103	39	bond	bond	NOUN
biomedich-710	103	40	acceptors	acceptor	NOUN
biomedich-710	103	41	,	,	PUNCT
biomedich-710	103	42	nhbd	nhbd	NOUN
biomedich-710	103	43	=	=	NOUN
biomedich-710	103	44	number	number	NOUN
biomedich-710	103	45	of	of	ADP
biomedich-710	103	46	h	h	NOUN
biomedich-710	103	47	-	-	PUNCT
biomedich-710	103	48	bond	bond	NOUN
biomedich-710	103	49	donors	donor	NOUN
biomedich-710	103	50	,	,	PUNCT
biomedich-710	103	51	tpsa	tpsa	NOUN
biomedich-710	103	52	=	=	PUNCT
biomedich-710	103	53	topological	topological	ADJ
biomedich-710	103	54	polar	polar	ADJ
biomedich-710	103	55	surface	surface	NOUN
biomedich-710	103	56	area	area	NOUN
biomedich-710	103	57	,	,	PUNCT
biomedich-710	103	58	o	o	NOUN
biomedich-710	103	59	/	/	SYM
biomedich-710	103	60	w	w	NOUN
biomedich-710	103	61	-	-	PUNCT
biomedich-710	103	62	pc	pc	NOUN
biomedich-710	103	63	=	=	NOUN
biomedich-710	103	64	octanol	octanol	NOUN
biomedich-710	103	65	/	/	SYM
biomedich-710	103	66	water	water	NOUN
biomedich-710	103	67	partition	partition	NOUN
biomedich-710	103	68	coefficient	coefficient	NOUN
biomedich-710	103	69	,	,	PUNCT
biomedich-710	103	70	lip	lip	PROPN
biomedich-710	103	71	=	=	SYM
biomedich-710	103	72	lipinski	lipinski	PROPN
biomedich-710	103	73	’s	’s	PART
biomedich-710	103	74	rule	rule	NOUN
biomedich-710	103	75	of	of	ADP
biomedich-710	103	76	five	five	NUM
biomedich-710	103	77	.	.	PUNCT
biomedich-710	104	1	veb	veb	PROPN
biomedich-710	104	2	=	=	SYM
biomedich-710	104	3	veber	veber	PROPN
biomedich-710	104	4	’s	’s	PART
biomedich-710	104	5	rule	rule	NOUN
biomedich-710	104	6	,	,	PUNCT
biomedich-710	104	7	bas	bas	PROPN
biomedich-710	104	8	=	=	PUNCT
biomedich-710	104	9	bio	bio	ADJ
biomedich-710	104	10	-	-	PUNCT
biomedich-710	104	11	availability	availability	NOUN
biomedich-710	104	12	score	score	NOUN
biomedich-710	104	13	.	.	PUNCT
biomedich-710	105	1	molecule	molecule	NOUN
biomedich-710	105	2	mw	mw	NOUN
biomedich-710	105	3	(	(	PUNCT
biomedich-710	105	4	g	g	NOUN
biomedich-710	105	5	/	/	SYM
biomedich-710	105	6	mol	mol	NOUN
biomedich-710	105	7	)	)	PUNCT
biomedich-710	105	8	nha	nha	X
biomedich-710	105	9	nrb	nrb	PROPN
biomedich-710	105	10	nhba	nhba	PROPN
biomedich-710	105	11	nhbd	nhbd	PROPN
biomedich-710	105	12	tpsa	tpsa	PROPN
biomedich-710	105	13	(	(	PUNCT
biomedich-710	105	14	å²	å²	PROPN
biomedich-710	105	15	)	)	PUNCT
biomedich-710	105	16	o	o	NOUN
biomedich-710	105	17	/	/	SYM
biomedich-710	105	18	w	w	NOUN
biomedich-710	105	19	-	-	PUNCT
biomedich-710	105	20	pc	pc	NOUN
biomedich-710	105	21	(	(	PUNCT
biomedich-710	105	22	mlogp	mlogp	NOUN
biomedich-710	105	23	)	)	PUNCT
biomedich-710	105	24	lip	lip	NOUN
biomedich-710	105	25	veb	veb	PROPN
biomedich-710	105	26	bas	bas	PROPN
biomedich-710	105	27	penicillin	penicillin	PROPN
biomedich-710	105	28	334.39	334.39	NUM
biomedich-710	105	29	23	23	NUM
biomedich-710	105	30	5	5	NUM
biomedich-710	105	31	4	4	NUM
biomedich-710	105	32	2	2	NUM
biomedich-710	105	33	112.01	112.01	NUM
biomedich-710	105	34	1.55	1.55	NUM
biomedich-710	106	1	yes	yes	INTJ
biomedich-710	106	2	yes	yes	INTJ
biomedich-710	106	3	0.56	0.56	NUM
biomedich-710	106	4	novobiocin	novobiocin	VERB
biomedich-710	106	5	612.62	612.62	NUM
biomedich-710	106	6	44	44	NUM
biomedich-710	106	7	10	10	NUM
biomedich-710	106	8	11	11	NUM
biomedich-710	106	9	5	5	NUM
biomedich-710	106	10	200.01	200.01	NUM
biomedich-710	106	11	0.65	0.65	NUM
biomedich-710	106	12	no	no	INTJ
biomedich-710	106	13	no	no	DET
biomedich-710	106	14	0.17	0.17	NUM
biomedich-710	106	15	quercetin	quercetin	NOUN
biomedich-710	106	16	302.24	302.24	NUM
biomedich-710	106	17	22	22	NUM
biomedich-710	106	18	1	1	NUM
biomedich-710	106	19	7	7	NUM
biomedich-710	106	20	5	5	NUM
biomedich-710	106	21	131.36	131.36	NUM
biomedich-710	106	22	-0.56	-0.56	NUM
biomedich-710	107	1	yes	yes	INTJ
biomedich-710	107	2	yes	yes	INTJ
biomedich-710	107	3	0.55	0.55	NUM
biomedich-710	107	4	kaempferol	kaempferol	VERB
biomedich-710	107	5	286.24	286.24	NUM
biomedich-710	107	6	21	21	NUM
biomedich-710	107	7	1	1	NUM
biomedich-710	107	8	6	6	NUM
biomedich-710	107	9	4	4	NUM
biomedich-710	107	10	111.13	111.13	NUM
biomedich-710	107	11	-0.03	-0.03	NUM
biomedich-710	108	1	yes	yes	INTJ
biomedich-710	108	2	yes	yes	INTJ
biomedich-710	108	3	0.55	0.55	NUM
biomedich-710	108	4	naringenin	naringenin	NOUN
biomedich-710	108	5	272.25	272.25	NUM
biomedich-710	108	6	20	20	NUM
biomedich-710	108	7	1	1	NUM
biomedich-710	108	8	5	5	NUM
biomedich-710	108	9	3	3	NUM
biomedich-710	108	10	86.99	86.99	NUM
biomedich-710	108	11	0.71	0.71	NUM
biomedich-710	109	1	yes	yes	INTJ
biomedich-710	110	1	yes	yes	INTJ
biomedich-710	110	2	0.55	0.55	NUM
biomedich-710	110	3	isoquercetin	isoquercetin	NOUN
biomedich-710	110	4	464.38	464.38	NUM
biomedich-710	110	5	33	33	NUM
biomedich-710	110	6	4	4	NUM
biomedich-710	110	7	12	12	NUM
biomedich-710	110	8	8	8	NUM
biomedich-710	110	9	210.51	210.51	NUM
biomedich-710	110	10	-2.59	-2.59	NOUN
biomedich-710	110	11	no	no	INTJ
biomedich-710	110	12	no	no	DET
biomedich-710	110	13	0.17	0.17	NUM
biomedich-710	110	14	lupeol	lupeol	NOUN
biomedich-710	110	15	426.72	426.72	NUM
biomedich-710	110	16	31	31	NUM
biomedich-710	110	17	1	1	NUM
biomedich-710	110	18	1	1	NUM
biomedich-710	110	19	1	1	NUM
biomedich-710	110	20	20.23	20.23	NUM
biomedich-710	110	21	6.92	6.92	NUM
biomedich-710	111	1	yes	yes	INTJ
biomedich-710	112	1	yes	yes	INTJ
biomedich-710	112	2	0.55	0.55	NUM
biomedich-710	112	3	beta	beta	NOUN
biomedich-710	112	4	-	-	PUNCT
biomedich-710	112	5	sitosterol	sitosterol	NOUN
biomedich-710	112	6	414.71	414.71	NUM
biomedich-710	112	7	30	30	NUM
biomedich-710	112	8	6	6	NUM
biomedich-710	112	9	1	1	NUM
biomedich-710	112	10	1	1	NUM
biomedich-710	112	11	20.23	20.23	NUM
biomedich-710	112	12	6.73	6.73	NUM
biomedich-710	113	1	yes	yes	INTJ
biomedich-710	114	1	yes	yes	INTJ
biomedich-710	114	2	0.55	0.55	NUM
biomedich-710	114	3	rutin	rutin	NOUN
biomedich-710	114	4	610.52	610.52	NUM
biomedich-710	114	5	43	43	NUM
biomedich-710	114	6	6	6	NUM
biomedich-710	114	7	16	16	NUM
biomedich-710	114	8	10	10	NUM
biomedich-710	114	9	269.43	269.43	NUM
biomedich-710	114	10	-3.89	-3.89	NOUN
biomedich-710	114	11	no	no	INTJ
biomedich-710	114	12	no	no	DET
biomedich-710	114	13	0.17	0.17	NUM
biomedich-710	114	14	sanguinarine	sanguinarine	NOUN
biomedich-710	114	15	332.33	332.33	NUM
biomedich-710	114	16	25	25	NUM
biomedich-710	114	17	0	0	NUM
biomedich-710	114	18	4	4	NUM
biomedich-710	114	19	0	0	NUM
biomedich-710	114	20	40.80	40.80	NUM
biomedich-710	114	21	2.72	2.72	NUM
biomedich-710	115	1	yes	yes	INTJ
biomedich-710	116	1	yes	yes	INTJ
biomedich-710	116	2	0.55	0.55	NUM
biomedich-710	116	3	548	548	NUM
biomedich-710	116	4	biology	biology	NOUN
biomedich-710	116	5	,	,	PUNCT
biomedich-710	116	6	medicine	medicine	NOUN
biomedich-710	116	7	,	,	PUNCT
biomedich-710	116	8	&	&	CCONJ
biomedich-710	116	9	natural	natural	ADJ
biomedich-710	116	10	product	product	NOUN
biomedich-710	116	11	chemistry	chemistry	NOUN
biomedich-710	116	12	14	14	NUM
biomedich-710	116	13	(	(	PUNCT
biomedich-710	116	14	1	1	NUM
biomedich-710	116	15	)	)	PUNCT
biomedich-710	116	16	,	,	PUNCT
biomedich-710	116	17	2025	2025	NUM
biomedich-710	116	18	:	:	PUNCT
biomedich-710	116	19	541	541	NUM
biomedich-710	116	20	-	-	SYM
biomedich-710	116	21	552	552	NUM
biomedich-710	116	22	table	table	NOUN
biomedich-710	116	23	9	9	NUM
biomedich-710	116	24	.	.	PUNCT
biomedich-710	116	25	predicted	predict	VERB
biomedich-710	116	26	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	116	27	parameters	parameter	NOUN
biomedich-710	116	28	of	of	ADP
biomedich-710	116	29	the	the	DET
biomedich-710	116	30	selected	select	VERB
biomedich-710	116	31	molecules	molecule	NOUN
biomedich-710	116	32	.	.	PUNCT
biomedich-710	117	1	penicillin	penicillin	PROPN
biomedich-710	117	2	novobiocin	novobiocin	PROPN
biomedich-710	117	3	quercetin	quercetin	NOUN
biomedich-710	117	4	kaempferol	kaempferol	PROPN
biomedich-710	117	5	naringenin	naringenin	PROPN
biomedich-710	117	6	absorption	absorption	NOUN
biomedich-710	117	7	caco2	caco2	NOUN
biomedich-710	117	8	permeability	permeability	NOUN
biomedich-710	117	9	(	(	PUNCT
biomedich-710	117	10	log	log	PROPN
biomedich-710	117	11	papp	papp	NOUN
biomedich-710	117	12	in	in	ADP
biomedich-710	117	13	10	10	NUM
biomedich-710	117	14	-	-	SYM
biomedich-710	117	15	6	6	NUM
biomedich-710	117	16	cm	cm	NOUN
biomedich-710	117	17	/	/	SYM
biomedich-710	117	18	s	s	NOUN
biomedich-710	117	19	)	)	PUNCT
biomedich-710	117	20	0.114	0.114	NUM
biomedich-710	117	21	-4.836	-4.836	PUNCT
biomedich-710	117	22	-0.229	-0.229	PUNCT
biomedich-710	117	23	0.032	0.032	NUM
biomedich-710	117	24	1.029	1.029	NUM
biomedich-710	117	25	water	water	NOUN
biomedich-710	117	26	solubility	solubility	NOUN
biomedich-710	117	27	(	(	PUNCT
biomedich-710	117	28	log	log	PROPN
biomedich-710	117	29	mol	mol	PROPN
biomedich-710	117	30	/	/	SYM
biomedich-710	117	31	l	l	NOUN
biomedich-710	117	32	)	)	PUNCT
biomedich-710	117	33	-2.47	-2.47	PROPN
biomedich-710	117	34	-0.427	-0.427	NUM
biomedich-710	117	35	-2.925	-2.925	NOUN
biomedich-710	117	36	-3.04	-3.04	NOUN
biomedich-710	117	37	-3.224	-3.224	PUNCT
biomedich-710	117	38	intestinal	intestinal	ADJ
biomedich-710	117	39	absorption	absorption	NOUN
biomedich-710	117	40	(	(	PUNCT
biomedich-710	117	41	human	human	NOUN
biomedich-710	117	42	)	)	PUNCT
biomedich-710	117	43	(	(	PUNCT
biomedich-710	117	44	%	%	NOUN
biomedich-710	117	45	absorbed	absorb	VERB
biomedich-710	117	46	)	)	PUNCT
biomedich-710	117	47	59.901	59.901	NUM
biomedich-710	117	48	66.418	66.418	NUM
biomedich-710	117	49	77.207	77.207	NUM
biomedich-710	117	50	74.29	74.29	NUM
biomedich-710	117	51	91.31	91.31	NUM
biomedich-710	117	52	skin	skin	NOUN
biomedich-710	117	53	permeability	permeability	NOUN
biomedich-710	117	54	(	(	PUNCT
biomedich-710	117	55	log	log	NOUN
biomedich-710	117	56	kp	kp	PROPN
biomedich-710	117	57	)	)	PUNCT
biomedich-710	117	58	-2.735	-2.735	NOUN
biomedich-710	117	59	-2.787	-2.787	NUM
biomedich-710	117	60	-2.735	-2.735	NOUN
biomedich-710	117	61	-2.735	-2.735	NOUN
biomedich-710	117	62	-2.742	-2.742	PUNCT
biomedich-710	117	63	p	p	NOUN
biomedich-710	117	64	-	-	PUNCT
biomedich-710	117	65	glycoprotein	glycoprotein	NOUN
biomedich-710	117	66	substrate	substrate	NOUN
biomedich-710	118	1	yes	yes	INTJ
biomedich-710	118	2	yes	yes	INTJ
biomedich-710	119	1	yes	yes	INTJ
biomedich-710	120	1	yes	yes	INTJ
biomedich-710	121	1	yes	yes	INTJ
biomedich-710	121	2	p	p	NOUN
biomedich-710	121	3	-	-	PUNCT
biomedich-710	121	4	glycoprotein	glycoprotein	NOUN
biomedich-710	121	5	i	i	PRON
biomedich-710	121	6	inhibitor	inhibitor	VERB
biomedich-710	122	1	no	no	INTJ
biomedich-710	122	2	yes	yes	INTJ
biomedich-710	123	1	no	no	INTJ
biomedich-710	123	2	no	no	INTJ
biomedich-710	124	1	no	no	DET
biomedich-710	124	2	p	p	NOUN
biomedich-710	124	3	-	-	PUNCT
biomedich-710	124	4	glycoprotein	glycoprotein	NOUN
biomedich-710	124	5	ii	ii	NOUN
biomedich-710	124	6	inhibitor	inhibitor	NOUN
biomedich-710	125	1	no	no	INTJ
biomedich-710	126	1	yes	yes	INTJ
biomedich-710	126	2	no	no	INTJ
biomedich-710	127	1	no	no	INTJ
biomedich-710	127	2	no	no	DET
biomedich-710	127	3	distribution	distribution	NOUN
biomedich-710	127	4	vdss	vdss	ADV
biomedich-710	127	5	(	(	PUNCT
biomedich-710	127	6	human	human	NOUN
biomedich-710	127	7	)	)	PUNCT
biomedich-710	127	8	(	(	PUNCT
biomedich-710	127	9	log	log	NOUN
biomedich-710	127	10	l	l	PROPN
biomedich-710	127	11	/	/	SYM
biomedich-710	127	12	kg	kg	NOUN
biomedich-710	127	13	)	)	PUNCT
biomedich-710	127	14	-1.905	-1.905	VERB
biomedich-710	127	15	-1.336	-1.336	NOUN
biomedich-710	127	16	1.559	1.559	NUM
biomedich-710	127	17	1.274	1.274	NUM
biomedich-710	127	18	-0.015	-0.015	PRON
biomedich-710	127	19	fraction	fraction	NOUN
biomedich-710	127	20	unbound	unbound	NOUN
biomedich-710	127	21	(	(	PUNCT
biomedich-710	127	22	human	human	NOUN
biomedich-710	127	23	)	)	PUNCT
biomedich-710	127	24	(	(	PUNCT
biomedich-710	127	25	fu	fu	NOUN
biomedich-710	127	26	)	)	PUNCT
biomedich-710	127	27	0.328	0.328	NUM
biomedich-710	127	28	0.127	0.127	NUM
biomedich-710	127	29	0.206	0.206	NUM
biomedich-710	127	30	0.178	0.178	NUM
biomedich-710	127	31	0.064	0.064	NUM
biomedich-710	127	32	bbb	bbb	NOUN
biomedich-710	127	33	permeability	permeability	NOUN
biomedich-710	127	34	(	(	PUNCT
biomedich-710	127	35	log	log	NOUN
biomedich-710	127	36	bb	bb	NUM
biomedich-710	127	37	)	)	PUNCT
biomedich-710	127	38	-0.864	-0.864	NOUN
biomedich-710	127	39	(	(	PUNCT
biomedich-710	127	40	no	no	INTJ
biomedich-710	127	41	)	)	PUNCT
biomedich-710	127	42	-1.914	-1.914	NOUN
biomedich-710	127	43	(	(	PUNCT
biomedich-710	127	44	no	no	INTJ
biomedich-710	127	45	)	)	PUNCT
biomedich-710	127	46	-1.098	-1.098	X
biomedich-710	127	47	(	(	PUNCT
biomedich-710	127	48	no	no	INTJ
biomedich-710	127	49	)	)	PUNCT
biomedich-710	127	50	-0.939	-0.939	NUM
biomedich-710	127	51	(	(	PUNCT
biomedich-710	127	52	no	no	NOUN
biomedich-710	127	53	)	)	PUNCT
biomedich-710	127	54	-0.578	-0.578	NOUN
biomedich-710	127	55	(	(	PUNCT
biomedich-710	127	56	no	no	NOUN
biomedich-710	127	57	)	)	PUNCT
biomedich-710	127	58	cns	cns	NOUN
biomedich-710	127	59	permeability	permeability	NOUN
biomedich-710	127	60	(	(	PUNCT
biomedich-710	127	61	log	log	NOUN
biomedich-710	127	62	ps	ps	NOUN
biomedich-710	127	63	)	)	PUNCT
biomedich-710	127	64	-2.943	-2.943	NUM
biomedich-710	128	1	-3.492	-3.492	PUNCT
biomedich-710	129	1	-3.065	-3.065	NOUN
biomedich-710	130	1	-2.228	-2.228	NOUN
biomedich-710	130	2	-2.215	-2.215	PUNCT
biomedich-710	130	3	metabolism	metabolism	NOUN
biomedich-710	130	4	cyp2d6	cyp2d6	NOUN
biomedich-710	130	5	substrate	substrate	NOUN
biomedich-710	130	6	no	no	INTJ
biomedich-710	130	7	no	no	INTJ
biomedich-710	130	8	no	no	INTJ
biomedich-710	131	1	no	no	INTJ
biomedich-710	131	2	no	no	DET
biomedich-710	131	3	cyp3a4	cyp3a4	NOUN
biomedich-710	131	4	substrate	substrate	NOUN
biomedich-710	132	1	no	no	INTJ
biomedich-710	132	2	yes	yes	INTJ
biomedich-710	132	3	no	no	INTJ
biomedich-710	132	4	no	no	INTJ
biomedich-710	132	5	no	no	INTJ
biomedich-710	132	6	cyp1a2	cyp1a2	ADJ
biomedich-710	132	7	inhibitor	inhibitor	NOUN
biomedich-710	133	1	no	no	INTJ
biomedich-710	134	1	no	no	INTJ
biomedich-710	135	1	yes	yes	INTJ
biomedich-710	136	1	yes	yes	INTJ
biomedich-710	136	2	yes	yes	INTJ
biomedich-710	136	3	cyp2c19	cyp2c19	NOUN
biomedich-710	136	4	inhibitor	inhibitor	NOUN
biomedich-710	137	1	no	no	INTJ
biomedich-710	137	2	no	no	INTJ
biomedich-710	137	3	no	no	INTJ
biomedich-710	137	4	no	no	INTJ
biomedich-710	138	1	no	no	DET
biomedich-710	138	2	cyp2c9	cyp2c9	NOUN
biomedich-710	138	3	inhibitor	inhibitor	NOUN
biomedich-710	139	1	no	no	INTJ
biomedich-710	140	1	no	no	INTJ
biomedich-710	140	2	no	no	INTJ
biomedich-710	140	3	no	no	INTJ
biomedich-710	140	4	no	no	DET
biomedich-710	140	5	cyp2d6	cyp2d6	NOUN
biomedich-710	140	6	inhibitor	inhibitor	NOUN
biomedich-710	141	1	no	no	INTJ
biomedich-710	141	2	no	no	INTJ
biomedich-710	141	3	no	no	INTJ
biomedich-710	141	4	no	no	INTJ
biomedich-710	141	5	no	no	DET
biomedich-710	141	6	cyp3a4	cyp3a4	NOUN
biomedich-710	141	7	inhibitor	inhibitor	NOUN
biomedich-710	142	1	no	no	INTJ
biomedich-710	143	1	yes	yes	INTJ
biomedich-710	144	1	no	no	INTJ
biomedich-710	144	2	no	no	INTJ
biomedich-710	144	3	no	no	DET
biomedich-710	144	4	excretion	excretion	NOUN
biomedich-710	144	5	total	total	NOUN
biomedich-710	144	6	clearance	clearance	NOUN
biomedich-710	144	7	(	(	PUNCT
biomedich-710	144	8	log	log	VERB
biomedich-710	144	9	ml	ml	NOUN
biomedich-710	144	10	/	/	SYM
biomedich-710	144	11	min	min	NOUN
biomedich-710	144	12	/	/	SYM
biomedich-710	144	13	kg	kg	PROPN
biomedich-710	144	14	)	)	PUNCT
biomedich-710	144	15	0.197	0.197	NUM
biomedich-710	144	16	-0.228	-0.228	VERB
biomedich-710	144	17	0.407	0.407	NUM
biomedich-710	144	18	0.477	0.477	NUM
biomedich-710	144	19	0.06	0.06	NUM
biomedich-710	144	20	renal	renal	ADJ
biomedich-710	144	21	oct2	oct2	NOUN
biomedich-710	144	22	substrate	substrate	NOUN
biomedich-710	145	1	no	no	INTJ
biomedich-710	145	2	no	no	INTJ
biomedich-710	145	3	no	no	INTJ
biomedich-710	145	4	no	no	INTJ
biomedich-710	145	5	no	no	DET
biomedich-710	145	6	toxicity	toxicity	NOUN
biomedich-710	145	7	ames	ame	NOUN
biomedich-710	145	8	toxicity	toxicity	NOUN
biomedich-710	146	1	no	no	INTJ
biomedich-710	146	2	no	no	INTJ
biomedich-710	146	3	no	no	INTJ
biomedich-710	146	4	no	no	INTJ
biomedich-710	147	1	no	no	DET
biomedich-710	147	2	max	max	PROPN
biomedich-710	147	3	.	.	PROPN
biomedich-710	147	4	tolerated	tolerate	VERB
biomedich-710	147	5	dose	dose	PROPN
biomedich-710	147	6	(	(	PUNCT
biomedich-710	147	7	human	human	NOUN
biomedich-710	147	8	)	)	PUNCT
biomedich-710	147	9	(	(	PUNCT
biomedich-710	147	10	log	log	VERB
biomedich-710	147	11	mg	mg	PROPN
biomedich-710	147	12	/	/	SYM
biomedich-710	147	13	kg	kg	PROPN
biomedich-710	147	14	/	/	SYM
biomedich-710	147	15	day	day	NOUN
biomedich-710	147	16	)	)	PUNCT
biomedich-710	147	17	0.692	0.692	NUM
biomedich-710	147	18	0.125	0.125	NUM
biomedich-710	147	19	0.499	0.499	NUM
biomedich-710	147	20	0.531	0.531	NUM
biomedich-710	147	21	-0.176	-0.176	NOUN
biomedich-710	147	22	herg	herg	INTJ
biomedich-710	148	1	i	i	PRON
biomedich-710	148	2	inhibitor	inhibitor	VERB
biomedich-710	149	1	no	no	INTJ
biomedich-710	149	2	no	no	INTJ
biomedich-710	149	3	no	no	INTJ
biomedich-710	149	4	no	no	INTJ
biomedich-710	150	1	no	no	INTJ
biomedich-710	150	2	herg	herg	PROPN
biomedich-710	150	3	ii	ii	PROPN
biomedich-710	150	4	inhibitor	inhibitor	NOUN
biomedich-710	151	1	no	no	INTJ
biomedich-710	152	1	yes	yes	INTJ
biomedich-710	152	2	no	no	INTJ
biomedich-710	153	1	no	no	INTJ
biomedich-710	153	2	no	no	DET
biomedich-710	153	3	oral	oral	ADJ
biomedich-710	153	4	rat	rat	NOUN
biomedich-710	153	5	acute	acute	NOUN
biomedich-710	153	6	toxicity	toxicity	NOUN
biomedich-710	153	7	(	(	PUNCT
biomedich-710	153	8	ld50	ld50	PROPN
biomedich-710	153	9	)	)	PUNCT
biomedich-710	153	10	(	(	PUNCT
biomedich-710	153	11	mol	mol	PROPN
biomedich-710	153	12	/	/	SYM
biomedich-710	153	13	kg	kg	NOUN
biomedich-710	153	14	)	)	PUNCT
biomedich-710	153	15	1.716	1.716	NUM
biomedich-710	153	16	2.085	2.085	NUM
biomedich-710	153	17	2.471	2.471	NUM
biomedich-710	153	18	2.449	2.449	NUM
biomedich-710	153	19	1.791	1.791	NUM
biomedich-710	153	20	oral	oral	ADJ
biomedich-710	153	21	rat	rat	NOUN
biomedich-710	153	22	chronic	chronic	ADJ
biomedich-710	153	23	toxicity	toxicity	NOUN
biomedich-710	153	24	(	(	PUNCT
biomedich-710	153	25	loael	loael	PROPN
biomedich-710	153	26	)	)	PUNCT
biomedich-710	153	27	(	(	PUNCT
biomedich-710	153	28	log	log	VERB
biomedich-710	153	29	mg	mg	PROPN
biomedich-710	153	30	/	/	SYM
biomedich-710	153	31	kg_bw	kg_bw	PROPN
biomedich-710	153	32	/	/	SYM
biomedich-710	153	33	day	day	NOUN
biomedich-710	153	34	)	)	PUNCT
biomedich-710	153	35	2.542	2.542	NUM
biomedich-710	153	36	2.095	2.095	NUM
biomedich-710	153	37	2.612	2.612	NUM
biomedich-710	153	38	2.505	2.505	NUM
biomedich-710	153	39	1.944	1.944	NUM
biomedich-710	153	40	hepatotoxicity	hepatotoxicity	NOUN
biomedich-710	154	1	yes	yes	INTJ
biomedich-710	154	2	no	no	INTJ
biomedich-710	154	3	no	no	INTJ
biomedich-710	154	4	no	no	INTJ
biomedich-710	154	5	no	no	DET
biomedich-710	154	6	skin	skin	NOUN
biomedich-710	154	7	sensitization	sensitization	NOUN
biomedich-710	155	1	no	no	INTJ
biomedich-710	155	2	no	no	INTJ
biomedich-710	155	3	no	no	INTJ
biomedich-710	155	4	no	no	INTJ
biomedich-710	155	5	no	no	DET
biomedich-710	155	6	t.	t.	NOUN
biomedich-710	155	7	pyriformis	pyriformis	NOUN
biomedich-710	155	8	toxicity	toxicity	NOUN
biomedich-710	155	9	(	(	PUNCT
biomedich-710	155	10	log	log	VERB
biomedich-710	155	11	ug	ug	ADP
biomedich-710	155	12	/	/	SYM
biomedich-710	155	13	l	l	NOUN
biomedich-710	155	14	)	)	PUNCT
biomedich-710	155	15	0.285	0.285	NUM
biomedich-710	155	16	0.288	0.288	NUM
biomedich-710	155	17	0.288	0.288	NUM
biomedich-710	155	18	0.312	0.312	NUM
biomedich-710	155	19	0.369	0.369	NUM
biomedich-710	155	20	minnow	minnow	NOUN
biomedich-710	155	21	toxicity	toxicity	NOUN
biomedich-710	155	22	(	(	PUNCT
biomedich-710	155	23	log	log	NOUN
biomedich-710	155	24	mm	mm	NOUN
biomedich-710	155	25	)	)	PUNCT
biomedich-710	155	26	3.698	3.698	NUM
biomedich-710	155	27	1.146	1.146	NUM
biomedich-710	155	28	3.721	3.721	NUM
biomedich-710	155	29	2.885	2.885	NUM
biomedich-710	155	30	2.136	2.136	NUM
biomedich-710	155	31	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	155	32	parameters	parameter	NOUN
biomedich-710	155	33	ligand	ligand	VERB
biomedich-710	155	34	isuranga	isuranga	PROPN
biomedich-710	155	35	&	&	CCONJ
biomedich-710	155	36	danthanarayana	danthanarayana	PROPN
biomedich-710	155	37	–	–	PUNCT
biomedich-710	155	38	antimicrobial	antimicrobial	ADJ
biomedich-710	155	39	potential	potential	NOUN
biomedich-710	155	40	of	of	ADP
biomedich-710	155	41	phytochemicals	phytochemical	NOUN
biomedich-710	155	42	from	from	ADP
biomedich-710	155	43	coccinia	coccinia	NOUN
biomedich-710	155	44	grandis	grandis	NOUN
biomedich-710	155	45	…	…	PUNCT
biomedich-710	155	46	549	549	NUM
biomedich-710	155	47	isoquercetin	isoquercetin	NOUN
biomedich-710	155	48	lupeol	lupeol	NOUN
biomedich-710	155	49	betasitosterol	betasitosterol	NOUN
biomedich-710	155	50	rutin	rutin	NOUN
biomedich-710	155	51	sanguinarin	sanguinarin	NOUN
biomedich-710	155	52	e	e	NOUN
biomedich-710	155	53	absorption	absorption	NOUN
biomedich-710	155	54	caco2	caco2	NOUN
biomedich-710	155	55	permeability	permeability	NOUN
biomedich-710	155	56	(	(	PUNCT
biomedich-710	155	57	log	log	PROPN
biomedich-710	155	58	papp	papp	NOUN
biomedich-710	155	59	in	in	ADP
biomedich-710	155	60	10	10	NUM
biomedich-710	155	61	-	-	SYM
biomedich-710	155	62	6	6	NUM
biomedich-710	155	63	cm	cm	NOUN
biomedich-710	155	64	/	/	SYM
biomedich-710	155	65	s	s	PART
biomedich-710	155	66	)	)	PUNCT
biomedich-710	155	67	0.242	0.242	NUM
biomedich-710	155	68	1.226	1.226	NUM
biomedich-710	155	69	1.201	1.201	NUM
biomedich-710	155	70	-0.949	-0.949	NUM
biomedich-710	155	71	2.107	2.107	NUM
biomedich-710	155	72	water	water	NOUN
biomedich-710	155	73	solubility	solubility	NOUN
biomedich-710	155	74	(	(	PUNCT
biomedich-710	155	75	log	log	PROPN
biomedich-710	155	76	mol	mol	PROPN
biomedich-710	155	77	/	/	SYM
biomedich-710	155	78	l	l	NOUN
biomedich-710	155	79	)	)	PUNCT
biomedich-710	155	80	-2.925	-2.925	PUNCT
biomedich-710	156	1	-5.861	-5.861	NUM
biomedich-710	156	2	-6.773	-6.773	X
biomedich-710	156	3	-2.892	-2.892	ADP
biomedich-710	156	4	-5.56	-5.56	DET
biomedich-710	156	5	intestinal	intestinal	ADJ
biomedich-710	156	6	absorption	absorption	NOUN
biomedich-710	156	7	(	(	PUNCT
biomedich-710	156	8	human	human	NOUN
biomedich-710	156	9	)	)	PUNCT
biomedich-710	156	10	(	(	PUNCT
biomedich-710	156	11	%	%	NOUN
biomedich-710	156	12	absorbed	absorb	VERB
biomedich-710	156	13	)	)	PUNCT
biomedich-710	156	14	47.999	47.999	NUM
biomedich-710	156	15	95.782	95.782	NUM
biomedich-710	156	16	94.464	94.464	NUM
biomedich-710	156	17	23.446	23.446	NUM
biomedich-710	156	18	100	100	NUM
biomedich-710	156	19	skin	skin	NOUN
biomedich-710	156	20	permeability	permeability	NOUN
biomedich-710	156	21	(	(	PUNCT
biomedich-710	156	22	log	log	PROPN
biomedich-710	156	23	kp	kp	NOUN
biomedich-710	156	24	)	)	PUNCT
biomedich-710	156	25	-2.735	-2.735	NOUN
biomedich-710	156	26	-2.744	-2.744	NUM
biomedich-710	156	27	-2.783	-2.783	NOUN
biomedich-710	156	28	-2.735	-2.735	NOUN
biomedich-710	156	29	-2.707	-2.707	PUNCT
biomedich-710	156	30	p	p	ADJ
biomedich-710	156	31	-	-	PUNCT
biomedich-710	156	32	glycoprotein	glycoprotein	NOUN
biomedich-710	156	33	substrate	substrate	NOUN
biomedich-710	157	1	yes	yes	INTJ
biomedich-710	157	2	no	no	INTJ
biomedich-710	158	1	no	no	INTJ
biomedich-710	159	1	yes	yes	INTJ
biomedich-710	160	1	yes	yes	INTJ
biomedich-710	160	2	p	p	NOUN
biomedich-710	160	3	-	-	PUNCT
biomedich-710	160	4	glycoprotein	glycoprotein	NOUN
biomedich-710	160	5	i	i	PRON
biomedich-710	160	6	inhibitor	inhibitor	VERB
biomedich-710	161	1	no	no	INTJ
biomedich-710	162	1	yes	yes	INTJ
biomedich-710	162	2	yes	yes	INTJ
biomedich-710	163	1	no	no	INTJ
biomedich-710	164	1	yes	yes	INTJ
biomedich-710	164	2	p	p	ADJ
biomedich-710	164	3	-	-	PUNCT
biomedich-710	164	4	glycoprotein	glycoprotein	NOUN
biomedich-710	164	5	ii	ii	NOUN
biomedich-710	164	6	inhibitor	inhibitor	NOUN
biomedich-710	165	1	no	no	INTJ
biomedich-710	166	1	yes	yes	INTJ
biomedich-710	167	1	yes	yes	INTJ
biomedich-710	168	1	no	no	INTJ
biomedich-710	168	2	yes	yes	INTJ
biomedich-710	168	3	distribution	distribution	NOUN
biomedich-710	168	4	vdss	vdss	ADV
biomedich-710	168	5	(	(	PUNCT
biomedich-710	168	6	human	human	NOUN
biomedich-710	168	7	)	)	PUNCT
biomedich-710	168	8	(	(	PUNCT
biomedich-710	168	9	log	log	NOUN
biomedich-710	168	10	l	l	PROPN
biomedich-710	168	11	/	/	SYM
biomedich-710	168	12	kg	kg	NOUN
biomedich-710	168	13	)	)	PUNCT
biomedich-710	168	14	1.846	1.846	NUM
biomedich-710	168	15	0	0	NUM
biomedich-710	168	16	0.193	0.193	NUM
biomedich-710	168	17	1.663	1.663	NUM
biomedich-710	168	18	0.298	0.298	NUM
biomedich-710	168	19	fraction	fraction	NOUN
biomedich-710	168	20	unbound	unbound	NOUN
biomedich-710	168	21	(	(	PUNCT
biomedich-710	168	22	human	human	NOUN
biomedich-710	168	23	)	)	PUNCT
biomedich-710	168	24	(	(	PUNCT
biomedich-710	168	25	fu	fu	PROPN
biomedich-710	168	26	)	)	PUNCT
biomedich-710	168	27	0.228	0.228	NUM
biomedich-710	168	28	0	0	NUM
biomedich-710	168	29	0	0	NUM
biomedich-710	168	30	0.187	0.187	NUM
biomedich-710	168	31	0.265	0.265	NUM
biomedich-710	168	32	bbb	bbb	NOUN
biomedich-710	168	33	permeability	permeability	NOUN
biomedich-710	168	34	(	(	PUNCT
biomedich-710	168	35	log	log	NOUN
biomedich-710	168	36	bb	bb	NUM
biomedich-710	168	37	)	)	PUNCT
biomedich-710	168	38	-1.688	-1.688	NUM
biomedich-710	168	39	(	(	PUNCT
biomedich-710	168	40	no	no	INTJ
biomedich-710	168	41	)	)	PUNCT
biomedich-710	168	42	0.726	0.726	NUM
biomedich-710	168	43	(	(	PUNCT
biomedich-710	168	44	no	no	NOUN
biomedich-710	168	45	)	)	PUNCT
biomedich-710	168	46	0.781	0.781	NUM
biomedich-710	168	47	(	(	PUNCT
biomedich-710	168	48	no	no	NOUN
biomedich-710	168	49	)	)	PUNCT
biomedich-710	168	50	-1.899	-1.899	NOUN
biomedich-710	168	51	(	(	PUNCT
biomedich-710	168	52	no	no	NOUN
biomedich-710	168	53	)	)	PUNCT
biomedich-710	168	54	-0.105	-0.105	NOUN
biomedich-710	168	55	(	(	PUNCT
biomedich-710	168	56	yes	yes	INTJ
biomedich-710	168	57	)	)	PUNCT
biomedich-710	168	58	cns	cns	NOUN
biomedich-710	168	59	permeability	permeability	NOUN
biomedich-710	168	60	(	(	PUNCT
biomedich-710	168	61	log	log	NOUN
biomedich-710	168	62	ps	ps	NOUN
biomedich-710	168	63	)	)	PUNCT
biomedich-710	168	64	-4.093	-4.093	PUNCT
biomedich-710	168	65	-1.714	-1.714	PUNCT
biomedich-710	168	66	-1.705	-1.705	NOUN
biomedich-710	168	67	-5.178	-5.178	PUNCT
biomedich-710	168	68	-1.419	-1.419	PUNCT
biomedich-710	168	69	metabolism	metabolism	NOUN
biomedich-710	168	70	cyp2d6	cyp2d6	NOUN
biomedich-710	168	71	substrate	substrate	NOUN
biomedich-710	169	1	no	no	INTJ
biomedich-710	169	2	no	no	INTJ
biomedich-710	169	3	no	no	INTJ
biomedich-710	169	4	no	no	INTJ
biomedich-710	169	5	no	no	DET
biomedich-710	169	6	cyp3a4	cyp3a4	NOUN
biomedich-710	169	7	substrate	substrate	NOUN
biomedich-710	170	1	no	no	INTJ
biomedich-710	171	1	yes	yes	INTJ
biomedich-710	171	2	yes	yes	INTJ
biomedich-710	172	1	no	no	INTJ
biomedich-710	173	1	yes	yes	INTJ
biomedich-710	173	2	cyp1a2	cyp1a2	ADJ
biomedich-710	173	3	inhibitor	inhibitor	NOUN
biomedich-710	174	1	no	no	INTJ
biomedich-710	174	2	no	no	INTJ
biomedich-710	175	1	no	no	INTJ
biomedich-710	175	2	no	no	INTJ
biomedich-710	175	3	yes	yes	INTJ
biomedich-710	175	4	cyp2c19	cyp2c19	ADJ
biomedich-710	175	5	inhibitor	inhibitor	NOUN
biomedich-710	176	1	no	no	INTJ
biomedich-710	176	2	no	no	INTJ
biomedich-710	176	3	no	no	INTJ
biomedich-710	177	1	no	no	INTJ
biomedich-710	177	2	yes	yes	INTJ
biomedich-710	177	3	cyp2c9	cyp2c9	NOUN
biomedich-710	177	4	inhibitor	inhibitor	NOUN
biomedich-710	178	1	no	no	INTJ
biomedich-710	178	2	no	no	INTJ
biomedich-710	178	3	no	no	INTJ
biomedich-710	178	4	no	no	INTJ
biomedich-710	178	5	no	no	DET
biomedich-710	178	6	cyp2d6	cyp2d6	NOUN
biomedich-710	178	7	inhibitor	inhibitor	NOUN
biomedich-710	179	1	no	no	INTJ
biomedich-710	179	2	no	no	INTJ
biomedich-710	179	3	no	no	INTJ
biomedich-710	180	1	no	no	INTJ
biomedich-710	180	2	yes	yes	INTJ
biomedich-710	180	3	cyp3a4	cyp3a4	NOUN
biomedich-710	180	4	inhibitor	inhibitor	NOUN
biomedich-710	181	1	no	no	INTJ
biomedich-710	181	2	no	no	INTJ
biomedich-710	182	1	no	no	INTJ
biomedich-710	182	2	no	no	INTJ
biomedich-710	183	1	yes	yes	INTJ
biomedich-710	183	2	excretion	excretion	NOUN
biomedich-710	183	3	total	total	NOUN
biomedich-710	183	4	clearance	clearance	NOUN
biomedich-710	183	5	(	(	PUNCT
biomedich-710	183	6	log	log	VERB
biomedich-710	183	7	ml	ml	NOUN
biomedich-710	183	8	/	/	SYM
biomedich-710	183	9	min	min	NOUN
biomedich-710	183	10	/	/	SYM
biomedich-710	183	11	kg	kg	NOUN
biomedich-710	183	12	)	)	PUNCT
biomedich-710	183	13	0.394	0.394	NUM
biomedich-710	183	14	0.153	0.153	NUM
biomedich-710	183	15	0.628	0.628	NUM
biomedich-710	183	16	-0.369	-0.369	SYM
biomedich-710	183	17	1.051	1.051	NUM
biomedich-710	183	18	renal	renal	ADJ
biomedich-710	183	19	oct2	oct2	NOUN
biomedich-710	183	20	substrate	substrate	NOUN
biomedich-710	184	1	no	no	INTJ
biomedich-710	184	2	no	no	INTJ
biomedich-710	184	3	no	no	INTJ
biomedich-710	184	4	no	no	INTJ
biomedich-710	184	5	no	no	DET
biomedich-710	184	6	toxicity	toxicity	NOUN
biomedich-710	184	7	ames	ame	NOUN
biomedich-710	184	8	toxicity	toxicity	NOUN
biomedich-710	185	1	no	no	INTJ
biomedich-710	185	2	no	no	INTJ
biomedich-710	185	3	no	no	INTJ
biomedich-710	186	1	no	no	INTJ
biomedich-710	186	2	yes	yes	INTJ
biomedich-710	187	1	max	max	PROPN
biomedich-710	187	2	.	.	PROPN
biomedich-710	187	3	tolerated	tolerate	VERB
biomedich-710	187	4	dose	dose	PROPN
biomedich-710	187	5	(	(	PUNCT
biomedich-710	187	6	human	human	NOUN
biomedich-710	187	7	)	)	PUNCT
biomedich-710	187	8	(	(	PUNCT
biomedich-710	187	9	log	log	VERB
biomedich-710	187	10	mg	mg	PROPN
biomedich-710	187	11	/	/	SYM
biomedich-710	187	12	kg	kg	PROPN
biomedich-710	187	13	/	/	SYM
biomedich-710	187	14	day	day	NOUN
biomedich-710	187	15	)	)	PUNCT
biomedich-710	187	16	0.569	0.569	NUM
biomedich-710	187	17	-0.502	-0.502	NUM
biomedich-710	187	18	-0.621	-0.621	PROPN
biomedich-710	187	19	0.452	0.452	NUM
biomedich-710	187	20	0.172	0.172	NUM
biomedich-710	187	21	herg	herg	PROPN
biomedich-710	188	1	i	i	PRON
biomedich-710	188	2	inhibitor	inhibitor	VERB
biomedich-710	189	1	no	no	INTJ
biomedich-710	189	2	no	no	INTJ
biomedich-710	189	3	no	no	INTJ
biomedich-710	189	4	no	no	INTJ
biomedich-710	190	1	no	no	INTJ
biomedich-710	190	2	herg	herg	PROPN
biomedich-710	190	3	ii	ii	PROPN
biomedich-710	190	4	inhibitor	inhibitor	NOUN
biomedich-710	191	1	yes	yes	INTJ
biomedich-710	192	1	yes	yes	INTJ
biomedich-710	193	1	yes	yes	INTJ
biomedich-710	194	1	yes	yes	INTJ
biomedich-710	194	2	yes	yes	INTJ
biomedich-710	194	3	oral	oral	ADJ
biomedich-710	194	4	rat	rat	NOUN
biomedich-710	194	5	acute	acute	NOUN
biomedich-710	194	6	toxicity	toxicity	NOUN
biomedich-710	194	7	(	(	PUNCT
biomedich-710	194	8	ld50	ld50	PROPN
biomedich-710	194	9	)	)	PUNCT
biomedich-710	194	10	(	(	PUNCT
biomedich-710	194	11	mol	mol	PROPN
biomedich-710	194	12	/	/	SYM
biomedich-710	194	13	kg	kg	NOUN
biomedich-710	194	14	)	)	PUNCT
biomedich-710	194	15	2.541	2.541	NUM
biomedich-710	194	16	2.563	2.563	NUM
biomedich-710	194	17	2.552	2.552	NUM
biomedich-710	194	18	2.491	2.491	NUM
biomedich-710	194	19	2.588	2.588	NUM
biomedich-710	194	20	oral	oral	ADJ
biomedich-710	194	21	rat	rat	NOUN
biomedich-710	194	22	chronic	chronic	ADJ
biomedich-710	194	23	toxicity	toxicity	NOUN
biomedich-710	194	24	(	(	PUNCT
biomedich-710	194	25	loael	loael	PROPN
biomedich-710	194	26	)	)	PUNCT
biomedich-710	194	27	(	(	PUNCT
biomedich-710	194	28	log	log	VERB
biomedich-710	194	29	mg	mg	PROPN
biomedich-710	194	30	/	/	SYM
biomedich-710	194	31	kg_bw	kg_bw	PROPN
biomedich-710	194	32	/	/	SYM
biomedich-710	194	33	day	day	NOUN
biomedich-710	194	34	)	)	PUNCT
biomedich-710	194	35	4.417	4.417	NUM
biomedich-710	194	36	0.89	0.89	NUM
biomedich-710	194	37	0.855	0.855	NUM
biomedich-710	194	38	3.673	3.673	NUM
biomedich-710	194	39	1.729	1.729	NUM
biomedich-710	194	40	hepatotoxicity	hepatotoxicity	NOUN
biomedich-710	195	1	no	no	INTJ
biomedich-710	195	2	no	no	INTJ
biomedich-710	195	3	no	no	INTJ
biomedich-710	195	4	no	no	INTJ
biomedich-710	195	5	no	no	DET
biomedich-710	195	6	skin	skin	NOUN
biomedich-710	195	7	sensitization	sensitization	NOUN
biomedich-710	196	1	no	no	INTJ
biomedich-710	196	2	no	no	INTJ
biomedich-710	196	3	no	no	INTJ
biomedich-710	196	4	no	no	INTJ
biomedich-710	196	5	no	no	DET
biomedich-710	196	6	t.	t.	NOUN
biomedich-710	196	7	pyriformis	pyriformis	NOUN
biomedich-710	196	8	toxicity	toxicity	NOUN
biomedich-710	196	9	(	(	PUNCT
biomedich-710	196	10	log	log	VERB
biomedich-710	196	11	ug	ug	ADP
biomedich-710	196	12	/	/	SYM
biomedich-710	196	13	l	l	NOUN
biomedich-710	196	14	)	)	PUNCT
biomedich-710	196	15	0.285	0.285	NUM
biomedich-710	196	16	0.316	0.316	NUM
biomedich-710	196	17	0.43	0.43	NUM
biomedich-710	196	18	0.285	0.285	NUM
biomedich-710	196	19	0.308	0.308	NUM
biomedich-710	196	20	minnow	minnow	NOUN
biomedich-710	196	21	toxicity	toxicity	NOUN
biomedich-710	196	22	(	(	PUNCT
biomedich-710	196	23	log	log	NOUN
biomedich-710	196	24	mm	mm	PROPN
biomedich-710	196	25	)	)	PUNCT
biomedich-710	196	26	8.061	8.061	NUM
biomedich-710	196	27	-1.696	-1.696	NOUN
biomedich-710	196	28	-1.802	-1.802	PUNCT
biomedich-710	196	29	7.677	7.677	NUM
biomedich-710	196	30	-0.718	-0.718	PUNCT
biomedich-710	196	31	discussion	discussion	NOUN
biomedich-710	196	32	quercetin	quercetin	NOUN
biomedich-710	196	33	,	,	PUNCT
biomedich-710	196	34	kaempferol	kaempferol	NOUN
biomedich-710	196	35	,	,	PUNCT
biomedich-710	196	36	naringenin	naringenin	NOUN
biomedich-710	196	37	,	,	PUNCT
biomedich-710	196	38	isoquercetin	isoquercetin	NOUN
biomedich-710	196	39	,	,	PUNCT
biomedich-710	196	40	rutin	rutin	NOUN
biomedich-710	196	41	are	be	AUX
biomedich-710	196	42	considered	consider	VERB
biomedich-710	196	43	as	as	ADP
biomedich-710	196	44	flavonoids	flavonoid	NOUN
biomedich-710	196	45	.	.	PUNCT
biomedich-710	197	1	lupeol	lupeol	NOUN
biomedich-710	197	2	is	be	AUX
biomedich-710	197	3	a	a	DET
biomedich-710	197	4	pentacyclic	pentacyclic	NOUN
biomedich-710	197	5	triterpenoid	triterpenoid	NOUN
biomedich-710	197	6	,	,	PUNCT
biomedich-710	197	7	while	while	SCONJ
biomedich-710	197	8	beta	beta	NOUN
biomedich-710	197	9	-	-	PUNCT
biomedich-710	197	10	sitosterol	sitosterol	NOUN
biomedich-710	197	11	is	be	AUX
biomedich-710	197	12	a	a	DET
biomedich-710	197	13	plant	plant	NOUN
biomedich-710	197	14	sterol	sterol	NOUN
biomedich-710	197	15	(	(	PUNCT
biomedich-710	197	16	phytosterol	phytosterol	NOUN
biomedich-710	197	17	)	)	PUNCT
biomedich-710	197	18	.	.	PUNCT
biomedich-710	198	1	sanguinarine	sanguinarine	PROPN
biomedich-710	198	2	belongs	belong	VERB
biomedich-710	198	3	to	to	ADP
biomedich-710	198	4	alkaloids	alkaloid	NOUN
biomedich-710	198	5	.	.	PUNCT
biomedich-710	199	1	pcoumaric	pcoumaric	PROPN
biomedich-710	199	2	acid	acid	PROPN
biomedich-710	199	3	is	be	AUX
biomedich-710	199	4	a	a	DET
biomedich-710	199	5	hydroxycinnamic	hydroxycinnamic	ADJ
biomedich-710	199	6	acid	acid	NOUN
biomedich-710	199	7	.	.	PUNCT
biomedich-710	200	1	the	the	DET
biomedich-710	200	2	inhibitory	inhibitory	ADJ
biomedich-710	200	3	constant	constant	ADJ
biomedich-710	200	4	,	,	PUNCT
biomedich-710	200	5	denoted	denote	VERB
biomedich-710	200	6	as	as	ADP
biomedich-710	200	7	ki	ki	PROPN
biomedich-710	200	8	(	(	PUNCT
biomedich-710	200	9	µm	µm	NOUN
biomedich-710	200	10	)	)	PUNCT
biomedich-710	200	11	,	,	PUNCT
biomedich-710	200	12	is	be	AUX
biomedich-710	200	13	a	a	DET
biomedich-710	200	14	measurement	measurement	NOUN
biomedich-710	200	15	used	use	VERB
biomedich-710	200	16	in	in	ADP
biomedich-710	200	17	pharmacology	pharmacology	NOUN
biomedich-710	200	18	to	to	PART
biomedich-710	200	19	understand	understand	VERB
biomedich-710	200	20	how	how	SCONJ
biomedich-710	200	21	tightly	tightly	ADV
biomedich-710	200	22	a	a	DET
biomedich-710	200	23	drug	drug	NOUN
biomedich-710	200	24	binds	bind	VERB
biomedich-710	200	25	(	(	PUNCT
biomedich-710	200	26	binding	bind	VERB
biomedich-710	200	27	affinity	affinity	NOUN
biomedich-710	200	28	)	)	PUNCT
biomedich-710	200	29	to	to	ADP
biomedich-710	200	30	a	a	DET
biomedich-710	200	31	specific	specific	ADJ
biomedich-710	200	32	molecule	molecule	NOUN
biomedich-710	200	33	(	(	PUNCT
biomedich-710	200	34	target	target	NOUN
biomedich-710	200	35	molecule	molecule	NOUN
biomedich-710	200	36	)	)	PUNCT
biomedich-710	200	37	.	.	PUNCT
biomedich-710	201	1	it	it	PRON
biomedich-710	201	2	reflects	reflect	VERB
biomedich-710	201	3	the	the	DET
biomedich-710	201	4	drug	drug	NOUN
biomedich-710	201	5	concentration	concentration	NOUN
biomedich-710	201	6	required	require	VERB
biomedich-710	201	7	to	to	PART
biomedich-710	201	8	occupy	occupy	VERB
biomedich-710	201	9	half	half	NOUN
biomedich-710	201	10	of	of	ADP
biomedich-710	201	11	the	the	DET
biomedich-710	201	12	available	available	ADJ
biomedich-710	201	13	binding	bind	VERB
biomedich-710	201	14	sites	site	NOUN
biomedich-710	201	15	.	.	PUNCT
biomedich-710	202	1	a	a	DET
biomedich-710	202	2	lower	low	ADJ
biomedich-710	202	3	ki	ki	PROPN
biomedich-710	202	4	value	value	NOUN
biomedich-710	202	5	indicates	indicate	VERB
biomedich-710	202	6	stronger	strong	ADJ
biomedich-710	202	7	binding	binding	NOUN
biomedich-710	202	8	.	.	PUNCT
biomedich-710	203	1	this	this	PRON
biomedich-710	203	2	means	mean	VERB
biomedich-710	203	3	a	a	DET
biomedich-710	203	4	lower	low	ADJ
biomedich-710	203	5	drug	drug	NOUN
biomedich-710	203	6	concentration	concentration	NOUN
biomedich-710	203	7	sufficient	sufficient	ADJ
biomedich-710	203	8	to	to	PART
biomedich-710	203	9	occupy	occupy	VERB
biomedich-710	203	10	half	half	NOUN
biomedich-710	203	11	(	(	PUNCT
biomedich-710	203	12	50	50	NUM
biomedich-710	203	13	%	%	NOUN
biomedich-710	203	14	)	)	PUNCT
biomedich-710	203	15	of	of	ADP
biomedich-710	203	16	the	the	DET
biomedich-710	203	17	available	available	ADJ
biomedich-710	203	18	binding	bind	VERB
biomedich-710	203	19	sites	site	NOUN
biomedich-710	203	20	.	.	PUNCT
biomedich-710	204	1	molecules	molecule	NOUN
biomedich-710	204	2	with	with	ADP
biomedich-710	204	3	ki	ki	PROPN
biomedich-710	204	4	values	value	NOUN
biomedich-710	204	5	less	less	ADJ
biomedich-710	204	6	than	than	ADP
biomedich-710	204	7	100	100	NUM
biomedich-710	204	8	µm	µm	NUM
biomedich-710	204	9	are	be	AUX
biomedich-710	204	10	considered	consider	VERB
biomedich-710	204	11	potent	potent	ADJ
biomedich-710	204	12	inhibitors	inhibitor	NOUN
biomedich-710	204	13	while	while	SCONJ
biomedich-710	204	14	molecules	molecule	NOUN
biomedich-710	204	15	with	with	ADP
biomedich-710	204	16	higher	high	ADJ
biomedich-710	204	17	ki	ki	PROPN
biomedich-710	204	18	values	value	NOUN
biomedich-710	204	19	than	than	ADP
biomedich-710	204	20	100	100	NUM
biomedich-710	204	21	µm	µm	NUM
biomedich-710	204	22	are	be	AUX
biomedich-710	204	23	considered	consider	VERB
biomedich-710	204	24	as	as	ADP
biomedich-710	204	25	non	non	ADJ
biomedich-710	204	26	-	-	ADJ
biomedich-710	204	27	potent	potent	ADJ
biomedich-710	204	28	inhibitors	inhibitor	NOUN
biomedich-710	204	29	(	(	PUNCT
biomedich-710	204	30	zheng	zheng	PROPN
biomedich-710	204	31	&	&	CCONJ
biomedich-710	204	32	polli	polli	PROPN
biomedich-710	204	33	,	,	PUNCT
biomedich-710	204	34	2010	2010	NUM
biomedich-710	204	35	)	)	PUNCT
biomedich-710	204	36	.	.	PUNCT
biomedich-710	205	1	lupeol	lupeol	NOUN
biomedich-710	205	2	(	(	PUNCT
biomedich-710	205	3	-7.72	-7.72	NOUN
biomedich-710	205	4	kcal	kcal	NOUN
biomedich-710	205	5	/	/	SYM
biomedich-710	205	6	mol	mol	NOUN
biomedich-710	205	7	)	)	PUNCT
biomedich-710	205	8	,	,	PUNCT
biomedich-710	205	9	beta	beta	NOUN
biomedich-710	205	10	-	-	PUNCT
biomedich-710	205	11	sitosterol	sitosterol	NOUN
biomedich-710	205	12	(	(	PUNCT
biomedich-710	205	13	-8.21	-8.21	NUM
biomedich-710	205	14	kcal	kcal	PROPN
biomedich-710	205	15	/	/	SYM
biomedich-710	205	16	mol	mol	NOUN
biomedich-710	205	17	)	)	PUNCT
biomedich-710	205	18	show	show	VERB
biomedich-710	205	19	higher	high	ADJ
biomedich-710	205	20	binding	bind	VERB
biomedich-710	205	21	affinity	affinity	NOUN
biomedich-710	205	22	to	to	PART
biomedich-710	205	23	pbp	pbp	VERB
biomedich-710	205	24	5	5	NUM
biomedich-710	205	25	of	of	ADP
biomedich-710	205	26	e.	e.	PROPN
biomedich-710	205	27	coli	coli	NOUN
biomedich-710	205	28	than	than	ADP
biomedich-710	205	29	the	the	DET
biomedich-710	205	30	penicillin	penicillin	NOUN
biomedich-710	205	31	(	(	PUNCT
biomedich-710	205	32	-7.20	-7.20	NUM
biomedich-710	205	33	kcal	kcal	NOUN
biomedich-710	205	34	/	/	SYM
biomedich-710	205	35	mol	mol	NOUN
biomedich-710	205	36	)	)	PUNCT
biomedich-710	205	37	which	which	PRON
biomedich-710	205	38	is	be	AUX
biomedich-710	205	39	the	the	DET
biomedich-710	205	40	reference	reference	NOUN
biomedich-710	205	41	molecule	molecule	NOUN
biomedich-710	205	42	.	.	PUNCT
biomedich-710	206	1	both	both	DET
biomedich-710	206	2	beta	beta	NOUN
biomedich-710	206	3	-	-	PUNCT
biomedich-710	206	4	sitosterol	sitosterol	NOUN
biomedich-710	206	5	(	(	PUNCT
biomedich-710	206	6	0.953	0.953	NUM
biomedich-710	206	7	µm	µm	NOUN
biomedich-710	206	8	)	)	PUNCT
biomedich-710	206	9	and	and	CCONJ
biomedich-710	206	10	lupeol	lupeol	NOUN
biomedich-710	206	11	(	(	PUNCT
biomedich-710	206	12	2.19	2.19	NUM
biomedich-710	206	13	µm	µm	NOUN
biomedich-710	206	14	)	)	PUNCT
biomedich-710	206	15	show	show	VERB
biomedich-710	206	16	lower	low	ADJ
biomedich-710	206	17	inhibition	inhibition	NOUN
biomedich-710	206	18	constant	constant	ADJ
biomedich-710	206	19	than	than	ADP
biomedich-710	206	20	penicillin	penicillin	NOUN
biomedich-710	206	21	(	(	PUNCT
biomedich-710	206	22	5.32	5.32	NUM
biomedich-710	206	23	µm	µm	NOUN
biomedich-710	206	24	)	)	PUNCT
biomedich-710	206	25	,	,	PUNCT
biomedich-710	206	26	indicating	indicate	VERB
biomedich-710	206	27	higher	high	ADJ
biomedich-710	206	28	potency	potency	NOUN
biomedich-710	206	29	than	than	ADP
biomedich-710	206	30	penicillin	penicillin	NOUN
biomedich-710	206	31	(	(	PUNCT
biomedich-710	206	32	table	table	NOUN
biomedich-710	206	33	2	2	NUM
biomedich-710	206	34	)	)	PUNCT
biomedich-710	206	35	.	.	PUNCT
biomedich-710	207	1	quercetin	quercetin	NOUN
biomedich-710	207	2	(	(	PUNCT
biomedich-710	207	3	-6.85	-6.85	PROPN
biomedich-710	207	4	kcal	kcal	PROPN
biomedich-710	207	5	/	/	SYM
biomedich-710	207	6	mol	mol	NOUN
biomedich-710	207	7	)	)	PUNCT
biomedich-710	207	8	,	,	PUNCT
biomedich-710	207	9	kaempferol	kaempferol	NOUN
biomedich-710	207	10	(	(	PUNCT
biomedich-710	207	11	-6.82	-6.82	NOUN
biomedich-710	207	12	kcal	kcal	PROPN
biomedich-710	207	13	/	/	SYM
biomedich-710	207	14	mol	mol	NOUN
biomedich-710	207	15	)	)	PUNCT
biomedich-710	207	16	,	,	PUNCT
biomedich-710	207	17	naringenin	naringenin	PROPN
biomedich-710	207	18	(	(	PUNCT
biomedich-710	207	19	-7.23	-7.23	PROPN
biomedich-710	207	20	kcal	kcal	PROPN
biomedich-710	207	21	/	/	SYM
biomedich-710	207	22	mol	mol	NOUN
biomedich-710	207	23	)	)	PUNCT
biomedich-710	207	24	,	,	PUNCT
biomedich-710	207	25	isoquercetin	isoquercetin	NOUN
biomedich-710	207	26	(	(	PUNCT
biomedich-710	207	27	6.20	6.20	NUM
biomedich-710	207	28	kcal	kcal	NOUN
biomedich-710	207	29	/	/	SYM
biomedich-710	207	30	mol	mol	NOUN
biomedich-710	207	31	)	)	PUNCT
biomedich-710	207	32	,	,	PUNCT
biomedich-710	207	33	lupeol	lupeol	NOUN
biomedich-710	207	34	(	(	PUNCT
biomedich-710	207	35	-7.67	-7.67	NOUN
biomedich-710	207	36	kcal	kcal	NOUN
biomedich-710	207	37	/	/	SYM
biomedich-710	207	38	mol	mol	NOUN
biomedich-710	207	39	)	)	PUNCT
biomedich-710	207	40	,	,	PUNCT
biomedich-710	207	41	beta	beta	NOUN
biomedich-710	207	42	-	-	PUNCT
biomedich-710	207	43	sitosterol	sitosterol	NOUN
biomedich-710	207	44	(	(	PUNCT
biomedich-710	207	45	-9.08	-9.08	PROPN
biomedich-710	207	46	kcal	kcal	NOUN
biomedich-710	207	47	/	/	SYM
biomedich-710	207	48	mol	mol	NOUN
biomedich-710	207	49	)	)	PUNCT
biomedich-710	207	50	and	and	CCONJ
biomedich-710	207	51	sanguinarine	sanguinarine	NOUN
biomedich-710	207	52	(	(	PUNCT
biomedich-710	207	53	-9.03	-9.03	NOUN
biomedich-710	207	54	kcal	kcal	NOUN
biomedich-710	207	55	/	/	SYM
biomedich-710	207	56	mol	mol	NOUN
biomedich-710	207	57	)	)	PUNCT
biomedich-710	207	58	show	show	VERB
biomedich-710	207	59	higher	high	ADJ
biomedich-710	207	60	binding	bind	VERB
biomedich-710	207	61	affinity	affinity	NOUN
biomedich-710	207	62	to	to	PART
biomedich-710	207	63	topoisomerase	topoisomerase	VERB
biomedich-710	207	64	iv	iv	NUM
biomedich-710	207	65	pare	pare	NOUN
biomedich-710	207	66	24kda	24kda	NOUN
biomedich-710	207	67	subunit	subunit	NOUN
biomedich-710	207	68	of	of	ADP
biomedich-710	207	69	e.	e.	PROPN
biomedich-710	207	70	coli	coli	PROPN
biomedich-710	207	71	than	than	ADP
biomedich-710	207	72	novobiocin	novobiocin	NOUN
biomedich-710	207	73	(	(	PUNCT
biomedich-710	207	74	-5.76	-5.76	PROPN
biomedich-710	207	75	kcal	kcal	PROPN
biomedich-710	207	76	/	/	SYM
biomedich-710	207	77	mol	mol	NOUN
biomedich-710	207	78	)	)	PUNCT
biomedich-710	207	79	.	.	PUNCT
biomedich-710	208	1	except	except	SCONJ
biomedich-710	208	2	for	for	ADP
biomedich-710	208	3	beta	beta	NOUN
biomedich-710	208	4	-	-	PUNCT
biomedich-710	208	5	sitosterol	sitosterol	NOUN
biomedich-710	208	6	,	,	PUNCT
biomedich-710	208	7	all	all	PRON
biomedich-710	208	8	above	above	ADV
biomedich-710	208	9	mentioned	mention	VERB
biomedich-710	208	10	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	208	11	parameters	parameter	NOUN
biomedich-710	208	12	ligand	ligand	VERB
biomedich-710	208	13	550	550	NUM
biomedich-710	208	14	biology	biology	NOUN
biomedich-710	208	15	,	,	PUNCT
biomedich-710	208	16	medicine	medicine	NOUN
biomedich-710	208	17	,	,	PUNCT
biomedich-710	208	18	&	&	CCONJ
biomedich-710	208	19	natural	natural	ADJ
biomedich-710	208	20	product	product	NOUN
biomedich-710	208	21	chemistry	chemistry	NOUN
biomedich-710	208	22	14	14	NUM
biomedich-710	208	23	(	(	PUNCT
biomedich-710	208	24	1	1	NUM
biomedich-710	208	25	)	)	PUNCT
biomedich-710	208	26	,	,	PUNCT
biomedich-710	208	27	2025	2025	NUM
biomedich-710	208	28	:	:	PUNCT
biomedich-710	208	29	541	541	NUM
biomedich-710	208	30	-	-	SYM
biomedich-710	208	31	552	552	NUM
biomedich-710	208	32	molecules	molecule	NOUN
biomedich-710	208	33	exhibit	exhibit	VERB
biomedich-710	208	34	a	a	DET
biomedich-710	208	35	lower	low	ADJ
biomedich-710	208	36	inhibition	inhibition	NOUN
biomedich-710	208	37	constant	constant	ADJ
biomedich-710	208	38	than	than	ADP
biomedich-710	208	39	novobiocin	novobiocin	NOUN
biomedich-710	208	40	(	(	PUNCT
biomedich-710	208	41	table	table	NOUN
biomedich-710	208	42	3	3	NUM
biomedich-710	208	43	)	)	PUNCT
biomedich-710	208	44	.	.	PUNCT
biomedich-710	209	1	quercetin	quercetin	NOUN
biomedich-710	209	2	(	(	PUNCT
biomedich-710	209	3	-6.70	-6.70	PROPN
biomedich-710	209	4	kcal	kcal	NOUN
biomedich-710	209	5	/	/	SYM
biomedich-710	209	6	mol	mol	NOUN
biomedich-710	209	7	)	)	PUNCT
biomedich-710	209	8	,	,	PUNCT
biomedich-710	209	9	kaempferol	kaempferol	NOUN
biomedich-710	209	10	(	(	PUNCT
biomedich-710	209	11	-6.95	-6.95	NOUN
biomedich-710	209	12	kcal	kcal	PROPN
biomedich-710	209	13	/	/	SYM
biomedich-710	209	14	mol	mol	NOUN
biomedich-710	209	15	)	)	PUNCT
biomedich-710	209	16	,	,	PUNCT
biomedich-710	209	17	naringenin	naringenin	PROPN
biomedich-710	209	18	(	(	PUNCT
biomedich-710	209	19	-7.07	-7.07	NOUN
biomedich-710	209	20	kcal	kcal	PROPN
biomedich-710	209	21	/	/	SYM
biomedich-710	209	22	mol	mol	NOUN
biomedich-710	209	23	)	)	PUNCT
biomedich-710	209	24	,	,	PUNCT
biomedich-710	209	25	isoquercetin	isoquercetin	NOUN
biomedich-710	209	26	(	(	PUNCT
biomedich-710	209	27	6.15	6.15	NUM
biomedich-710	209	28	kcal	kcal	NOUN
biomedich-710	209	29	/	/	SYM
biomedich-710	209	30	mol	mol	NOUN
biomedich-710	209	31	)	)	PUNCT
biomedich-710	209	32	,	,	PUNCT
biomedich-710	209	33	lupeol	lupeol	NOUN
biomedich-710	209	34	(	(	PUNCT
biomedich-710	209	35	-7.87	-7.87	NUM
biomedich-710	209	36	kcal	kcal	NOUN
biomedich-710	209	37	/	/	SYM
biomedich-710	209	38	mol	mol	NOUN
biomedich-710	209	39	)	)	PUNCT
biomedich-710	209	40	,	,	PUNCT
biomedich-710	209	41	beta	beta	NOUN
biomedich-710	209	42	-	-	PUNCT
biomedich-710	209	43	sitosterol	sitosterol	NOUN
biomedich-710	209	44	(	(	PUNCT
biomedich-710	209	45	-9.42	-9.42	ADP
biomedich-710	209	46	kcal	kcal	PROPN
biomedich-710	209	47	/	/	SYM
biomedich-710	209	48	mol	mol	NOUN
biomedich-710	209	49	)	)	PUNCT
biomedich-710	209	50	and	and	CCONJ
biomedich-710	209	51	sanguinarine	sanguinarine	NOUN
biomedich-710	209	52	(	(	PUNCT
biomedich-710	209	53	-9.07	-9.07	NOUN
biomedich-710	209	54	kcal	kcal	PROPN
biomedich-710	209	55	/	/	SYM
biomedich-710	209	56	mol	mol	NOUN
biomedich-710	209	57	)	)	PUNCT
biomedich-710	209	58	show	show	VERB
biomedich-710	209	59	higher	high	ADJ
biomedich-710	209	60	binding	bind	VERB
biomedich-710	209	61	affinity	affinity	NOUN
biomedich-710	209	62	to	to	PART
biomedich-710	209	63	dna	dna	VERB
biomedich-710	209	64	topoisomerase	topoisomerase	VERB
biomedich-710	209	65	iv	iv	NUM
biomedich-710	209	66	subunit	subunit	NOUN
biomedich-710	209	67	b	b	PROPN
biomedich-710	209	68	(	(	PUNCT
biomedich-710	209	69	pare	pare	PROPN
biomedich-710	209	70	24kd	24kd	ADJ
biomedich-710	209	71	)	)	PUNCT
biomedich-710	209	72	of	of	ADP
biomedich-710	209	73	s.	s.	PROPN
biomedich-710	209	74	aureus	aureus	PROPN
biomedich-710	209	75	than	than	ADP
biomedich-710	209	76	novobiocin	novobiocin	NOUN
biomedich-710	209	77	(	(	PUNCT
biomedich-710	209	78	-6.04	-6.04	NOUN
biomedich-710	209	79	kcal	kcal	NOUN
biomedich-710	209	80	/	/	SYM
biomedich-710	209	81	mol	mol	NOUN
biomedich-710	209	82	)	)	PUNCT
biomedich-710	209	83	.	.	PUNCT
biomedich-710	210	1	all	all	DET
biomedich-710	210	2	these	these	DET
biomedich-710	210	3	molecules	molecule	NOUN
biomedich-710	210	4	exhibit	exhibit	VERB
biomedich-710	210	5	lower	low	ADJ
biomedich-710	210	6	inhibition	inhibition	NOUN
biomedich-710	210	7	constant	constant	ADJ
biomedich-710	210	8	than	than	ADP
biomedich-710	210	9	novobiocin	novobiocin	NOUN
biomedich-710	210	10	(	(	PUNCT
biomedich-710	210	11	table	table	NOUN
biomedich-710	210	12	4	4	NUM
biomedich-710	210	13	)	)	PUNCT
biomedich-710	210	14	.	.	PUNCT
biomedich-710	211	1	among	among	ADP
biomedich-710	211	2	these	these	DET
biomedich-710	211	3	molecules	molecule	NOUN
biomedich-710	211	4	beta	beta	NOUN
biomedich-710	211	5	-	-	PUNCT
biomedich-710	211	6	sitosterol	sitosterol	NOUN
biomedich-710	211	7	shows	show	VERB
biomedich-710	211	8	the	the	DET
biomedich-710	211	9	highest	high	ADJ
biomedich-710	211	10	binding	bind	VERB
biomedich-710	211	11	affinity	affinity	NOUN
biomedich-710	211	12	and	and	CCONJ
biomedich-710	211	13	the	the	DET
biomedich-710	211	14	lowest	low	ADJ
biomedich-710	211	15	inhibition	inhibition	NOUN
biomedich-710	211	16	constant	constant	ADJ
biomedich-710	211	17	towards	towards	ADP
biomedich-710	211	18	topoisomerase	topoisomerase	PROPN
biomedich-710	211	19	iv	iv	NUM
biomedich-710	211	20	pare	pare	NOUN
biomedich-710	211	21	24kda	24kda	NOUN
biomedich-710	211	22	subunit	subunit	NOUN
biomedich-710	211	23	of	of	ADP
biomedich-710	211	24	s.	s.	PROPN
biomedich-710	211	25	aureus	aureus	PROPN
biomedich-710	211	26	.	.	PUNCT
biomedich-710	212	1	interactions	interaction	NOUN
biomedich-710	212	2	between	between	ADP
biomedich-710	212	3	a	a	DET
biomedich-710	212	4	ligand	ligand	NOUN
biomedich-710	212	5	and	and	CCONJ
biomedich-710	212	6	a	a	DET
biomedich-710	212	7	protein	protein	NOUN
biomedich-710	212	8	are	be	AUX
biomedich-710	212	9	crucial	crucial	ADJ
biomedich-710	212	10	for	for	ADP
biomedich-710	212	11	understanding	understand	VERB
biomedich-710	212	12	biochemical	biochemical	ADJ
biomedich-710	212	13	processes	process	NOUN
biomedich-710	212	14	,	,	PUNCT
biomedich-710	212	15	particularly	particularly	ADV
biomedich-710	212	16	in	in	ADP
biomedich-710	212	17	protein	protein	NOUN
biomedich-710	212	18	function	function	NOUN
biomedich-710	212	19	and	and	CCONJ
biomedich-710	212	20	stability	stability	NOUN
biomedich-710	212	21	.	.	PUNCT
biomedich-710	213	1	two	two	NUM
biomedich-710	213	2	major	major	ADJ
biomedich-710	213	3	types	type	NOUN
biomedich-710	213	4	of	of	ADP
biomedich-710	213	5	interactions	interaction	NOUN
biomedich-710	213	6	that	that	PRON
biomedich-710	213	7	can	can	AUX
biomedich-710	213	8	be	be	AUX
biomedich-710	213	9	observed	observe	VERB
biomedich-710	213	10	are	be	AUX
biomedich-710	213	11	hydrogen	hydrogen	NOUN
biomedich-710	213	12	bonds	bond	NOUN
biomedich-710	213	13	(	(	PUNCT
biomedich-710	213	14	hbonds	hbond	NOUN
biomedich-710	213	15	)	)	PUNCT
biomedich-710	213	16	and	and	CCONJ
biomedich-710	213	17	hydrophobic	hydrophobic	NOUN
biomedich-710	213	18	interactions	interaction	NOUN
biomedich-710	213	19	.	.	PUNCT
biomedich-710	214	1	hydrogen	hydrogen	NOUN
biomedich-710	214	2	bonds	bond	NOUN
biomedich-710	214	3	significantly	significantly	ADV
biomedich-710	214	4	contribute	contribute	VERB
biomedich-710	214	5	to	to	ADP
biomedich-710	214	6	the	the	DET
biomedich-710	214	7	stability	stability	NOUN
biomedich-710	214	8	of	of	ADP
biomedich-710	214	9	the	the	DET
biomedich-710	214	10	protein	protein	NOUN
biomedich-710	214	11	structure	structure	NOUN
biomedich-710	214	12	.	.	PUNCT
biomedich-710	215	1	furthermore	furthermore	ADV
biomedich-710	215	2	,	,	PUNCT
biomedich-710	215	3	h	h	NOUN
biomedich-710	215	4	-	-	PUNCT
biomedich-710	215	5	bonds	bond	NOUN
biomedich-710	215	6	can	can	AUX
biomedich-710	215	7	provide	provide	VERB
biomedich-710	215	8	specificity	specificity	NOUN
biomedich-710	215	9	in	in	ADP
biomedich-710	215	10	ligand	ligand	ADJ
biomedich-710	215	11	binding	binding	NOUN
biomedich-710	215	12	.	.	PUNCT
biomedich-710	216	1	the	the	DET
biomedich-710	216	2	precise	precise	ADJ
biomedich-710	216	3	arrangement	arrangement	NOUN
biomedich-710	216	4	of	of	ADP
biomedich-710	216	5	h	h	NOUN
biomedich-710	216	6	-	-	PUNCT
biomedich-710	216	7	bond	bond	NOUN
biomedich-710	216	8	donors	donor	NOUN
biomedich-710	216	9	and	and	CCONJ
biomedich-710	216	10	acceptors	acceptor	NOUN
biomedich-710	216	11	facilitates	facilitate	VERB
biomedich-710	216	12	selective	selective	ADJ
biomedich-710	216	13	binding	binding	NOUN
biomedich-710	216	14	of	of	ADP
biomedich-710	216	15	ligands	ligand	NOUN
biomedich-710	216	16	.	.	PUNCT
biomedich-710	217	1	higher	high	ADJ
biomedich-710	217	2	the	the	DET
biomedich-710	217	3	number	number	NOUN
biomedich-710	217	4	of	of	ADP
biomedich-710	217	5	h	h	NOUN
biomedich-710	217	6	-	-	PUNCT
biomedich-710	217	7	bonds	bond	NOUN
biomedich-710	217	8	,	,	PUNCT
biomedich-710	217	9	greater	great	ADJ
biomedich-710	217	10	the	the	DET
biomedich-710	217	11	binding	bind	VERB
biomedich-710	217	12	efficiency	efficiency	NOUN
biomedich-710	217	13	and	and	CCONJ
biomedich-710	217	14	the	the	DET
biomedich-710	217	15	inhibition	inhibition	NOUN
biomedich-710	217	16	(	(	PUNCT
biomedich-710	217	17	kumar	kumar	PROPN
biomedich-710	217	18	et	et	PROPN
biomedich-710	217	19	al	al	PROPN
biomedich-710	217	20	.	.	PROPN
biomedich-710	217	21	,	,	PUNCT
biomedich-710	217	22	2015	2015	NUM
biomedich-710	217	23	)	)	PUNCT
biomedich-710	217	24	.	.	PUNCT
biomedich-710	218	1	hydrophobic	hydrophobic	NOUN
biomedich-710	218	2	interactions	interaction	NOUN
biomedich-710	218	3	drive	drive	VERB
biomedich-710	218	4	protein	protein	NOUN
biomedich-710	218	5	folding	folding	NOUN
biomedich-710	218	6	and	and	CCONJ
biomedich-710	218	7	significantly	significantly	ADV
biomedich-710	218	8	contribute	contribute	VERB
biomedich-710	218	9	to	to	ADP
biomedich-710	218	10	the	the	DET
biomedich-710	218	11	stability	stability	NOUN
biomedich-710	218	12	of	of	ADP
biomedich-710	218	13	the	the	DET
biomedich-710	218	14	protein	protein	NOUN
biomedich-710	218	15	.	.	PUNCT
biomedich-710	219	1	in	in	ADP
biomedich-710	219	2	h	h	NOUN
biomedich-710	219	3	-	-	PUNCT
biomedich-710	219	4	bond	bond	NOUN
biomedich-710	219	5	interactions	interaction	NOUN
biomedich-710	219	6	analysis	analysis	NOUN
biomedich-710	219	7	,	,	PUNCT
biomedich-710	219	8	penicillin	penicillin	NOUN
biomedich-710	219	9	forms	form	VERB
biomedich-710	219	10	three	three	NUM
biomedich-710	219	11	h	h	NOUN
biomedich-710	219	12	-	-	PUNCT
biomedich-710	219	13	bonds	bond	NOUN
biomedich-710	219	14	with	with	ADP
biomedich-710	219	15	three	three	NUM
biomedich-710	219	16	amino	amino	ADJ
biomedich-710	219	17	acids	acid	NOUN
biomedich-710	219	18	(	(	PUNCT
biomedich-710	219	19	ser44	ser44	NOUN
biomedich-710	219	20	,	,	PUNCT
biomedich-710	219	21	ser87	ser87	NOUN
biomedich-710	219	22	,	,	PUNCT
biomedich-710	219	23	and	and	CCONJ
biomedich-710	219	24	asn112	asn112	PROPN
biomedich-710	219	25	)	)	PUNCT
biomedich-710	219	26	located	locate	VERB
biomedich-710	219	27	in	in	ADP
biomedich-710	219	28	the	the	DET
biomedich-710	219	29	active	active	ADJ
biomedich-710	219	30	site	site	NOUN
biomedich-710	219	31	of	of	ADP
biomedich-710	219	32	the	the	DET
biomedich-710	219	33	pbp5	pbp5	NOUN
biomedich-710	219	34	.	.	PUNCT
biomedich-710	220	1	in	in	ADP
biomedich-710	220	2	the	the	DET
biomedich-710	220	3	case	case	NOUN
biomedich-710	220	4	of	of	ADP
biomedich-710	220	5	pbp5	pbp5	NOUN
biomedich-710	220	6	and	and	CCONJ
biomedich-710	220	7	lupeol	lupeol	VERB
biomedich-710	220	8	one	one	NUM
biomedich-710	220	9	h	h	NOUN
biomedich-710	220	10	-	-	PUNCT
biomedich-710	220	11	bonding	bond	VERB
biomedich-710	220	12	interaction	interaction	NOUN
biomedich-710	220	13	was	be	AUX
biomedich-710	220	14	observed	observe	VERB
biomedich-710	220	15	(	(	PUNCT
biomedich-710	220	16	ser44	ser44	NOUN
biomedich-710	220	17	)	)	PUNCT
biomedich-710	220	18	,	,	PUNCT
biomedich-710	220	19	while	while	SCONJ
biomedich-710	220	20	pbp5	pbp5	NOUN
biomedich-710	220	21	and	and	CCONJ
biomedich-710	220	22	beta	beta	NOUN
biomedich-710	220	23	-	-	PUNCT
biomedich-710	220	24	sitosterol	sitosterol	NOUN
biomedich-710	220	25	exhibit	exhibit	VERB
biomedich-710	220	26	one	one	NUM
biomedich-710	220	27	h	h	NOUN
biomedich-710	220	28	-	-	PUNCT
biomedich-710	220	29	bond	bond	NOUN
biomedich-710	220	30	(	(	PUNCT
biomedich-710	220	31	asn112	asn112	PROPN
biomedich-710	220	32	)	)	PUNCT
biomedich-710	220	33	(	(	PUNCT
biomedich-710	220	34	figure	figure	NOUN
biomedich-710	220	35	3	3	NUM
biomedich-710	220	36	and	and	CCONJ
biomedich-710	220	37	table	table	NOUN
biomedich-710	220	38	5	5	NUM
biomedich-710	220	39	)	)	PUNCT
biomedich-710	220	40	.	.	PUNCT
biomedich-710	221	1	two	two	NUM
biomedich-710	221	2	h	h	NOUN
biomedich-710	221	3	-	-	PUNCT
biomedich-710	221	4	bonds	bond	NOUN
biomedich-710	221	5	were	be	AUX
biomedich-710	221	6	observed	observe	VERB
biomedich-710	221	7	between	between	ADP
biomedich-710	221	8	the	the	DET
biomedich-710	221	9	topoisomerase	topoisomerase	NOUN
biomedich-710	221	10	iv	iv	NUM
biomedich-710	221	11	pare	pare	NOUN
biomedich-710	221	12	24kda	24kda	NOUN
biomedich-710	221	13	subunit	subunit	NOUN
biomedich-710	221	14	of	of	ADP
biomedich-710	221	15	e.	e.	PROPN
biomedich-710	221	16	coli	coli	PROPN
biomedich-710	221	17	and	and	CCONJ
biomedich-710	221	18	novobiocin	novobiocin	PROPN
biomedich-710	221	19	(	(	PUNCT
biomedich-710	221	20	his1079	his1079	NOUN
biomedich-710	221	21	and	and	CCONJ
biomedich-710	221	22	ile1078	ile1078	NOUN
biomedich-710	221	23	)	)	PUNCT
biomedich-710	221	24	.	.	PUNCT
biomedich-710	222	1	additionally	additionally	ADV
biomedich-710	222	2	,	,	PUNCT
biomedich-710	222	3	quercetin	quercetin	NOUN
biomedich-710	222	4	forms	form	NOUN
biomedich-710	222	5	four	four	NUM
biomedich-710	222	6	h	h	NOUN
biomedich-710	222	7	-	-	PUNCT
biomedich-710	222	8	bonds	bond	NOUN
biomedich-710	222	9	with	with	ADP
biomedich-710	222	10	three	three	NUM
biomedich-710	222	11	amino	amino	ADJ
biomedich-710	222	12	acids	acid	NOUN
biomedich-710	222	13	(	(	PUNCT
biomedich-710	222	14	asn1042	asn1042	NOUN
biomedich-710	222	15	,	,	PUNCT
biomedich-710	222	16	glu1046	glu1046	NOUN
biomedich-710	222	17	and	and	CCONJ
biomedich-710	222	18	val1039	val1039	NOUN
biomedich-710	222	19	)	)	PUNCT
biomedich-710	222	20	in	in	ADP
biomedich-710	222	21	the	the	DET
biomedich-710	222	22	active	active	ADJ
biomedich-710	222	23	site	site	NOUN
biomedich-710	222	24	of	of	ADP
biomedich-710	222	25	this	this	DET
biomedich-710	222	26	protein	protein	NOUN
biomedich-710	222	27	.	.	PUNCT
biomedich-710	223	1	five	five	NUM
biomedich-710	223	2	h	h	NOUN
biomedich-710	223	3	-	-	PUNCT
biomedich-710	223	4	bonds	bond	NOUN
biomedich-710	223	5	with	with	ADP
biomedich-710	223	6	five	five	NUM
biomedich-710	223	7	amino	amino	ADJ
biomedich-710	223	8	acids	acid	NOUN
biomedich-710	223	9	in	in	ADP
biomedich-710	223	10	the	the	DET
biomedich-710	223	11	active	active	ADJ
biomedich-710	223	12	site	site	NOUN
biomedich-710	223	13	,	,	PUNCT
biomedich-710	223	14	were	be	AUX
biomedich-710	223	15	observed	observe	VERB
biomedich-710	223	16	between	between	ADP
biomedich-710	223	17	kaempferol	kaempferol	NOUN
biomedich-710	223	18	and	and	CCONJ
biomedich-710	223	19	the	the	DET
biomedich-710	223	20	protein	protein	NOUN
biomedich-710	223	21	(	(	PUNCT
biomedich-710	223	22	arg1072	arg1072	NOUN
biomedich-710	223	23	,	,	PUNCT
biomedich-710	223	24	gly1073	gly1073	NOUN
biomedich-710	223	25	,	,	PUNCT
biomedich-710	223	26	val1039	val1039	NOUN
biomedich-710	223	27	,	,	PUNCT
biomedich-710	223	28	aso1069	aso1069	NOUN
biomedich-710	223	29	and	and	CCONJ
biomedich-710	223	30	glu1046	glu1046	NOUN
biomedich-710	223	31	)	)	PUNCT
biomedich-710	223	32	.	.	PUNCT
biomedich-710	224	1	similarly	similarly	ADV
biomedich-710	224	2	,	,	PUNCT
biomedich-710	224	3	four	four	NUM
biomedich-710	224	4	h	h	NOUN
biomedich-710	224	5	-	-	PUNCT
biomedich-710	224	6	bonds	bond	NOUN
biomedich-710	224	7	with	with	ADP
biomedich-710	224	8	four	four	NUM
biomedich-710	224	9	amino	amino	ADJ
biomedich-710	224	10	acids	acid	NOUN
biomedich-710	224	11	in	in	ADP
biomedich-710	224	12	the	the	DET
biomedich-710	224	13	active	active	ADJ
biomedich-710	224	14	site	site	NOUN
biomedich-710	224	15	,	,	PUNCT
biomedich-710	224	16	were	be	AUX
biomedich-710	224	17	observed	observe	VERB
biomedich-710	224	18	between	between	ADP
biomedich-710	224	19	naringenin	naringenin	PROPN
biomedich-710	224	20	and	and	CCONJ
biomedich-710	224	21	the	the	DET
biomedich-710	224	22	protein	protein	NOUN
biomedich-710	224	23	(	(	PUNCT
biomedich-710	224	24	arg1072	arg1072	NOUN
biomedich-710	224	25	,	,	PUNCT
biomedich-710	224	26	gly1073	gly1073	NOUN
biomedich-710	224	27	,	,	PUNCT
biomedich-710	224	28	val1039	val1039	NOUN
biomedich-710	224	29	and	and	CCONJ
biomedich-710	224	30	glu1046	glu1046	NOUN
biomedich-710	224	31	)	)	PUNCT
biomedich-710	224	32	.	.	PUNCT
biomedich-710	225	1	the	the	DET
biomedich-710	225	2	highest	high	ADJ
biomedich-710	225	3	number	number	NOUN
biomedich-710	225	4	of	of	ADP
biomedich-710	225	5	hbonds	hbond	NOUN
biomedich-710	225	6	was	be	AUX
biomedich-710	225	7	observed	observe	VERB
biomedich-710	225	8	between	between	ADP
biomedich-710	225	9	isoquercetin	isoquercetin	NOUN
biomedich-710	225	10	and	and	CCONJ
biomedich-710	225	11	the	the	DET
biomedich-710	225	12	protein	protein	NOUN
biomedich-710	225	13	,	,	PUNCT
biomedich-710	225	14	seven	seven	NUM
biomedich-710	225	15	h	h	NOUN
biomedich-710	225	16	-	-	PUNCT
biomedich-710	225	17	bonds	bond	NOUN
biomedich-710	225	18	with	with	ADP
biomedich-710	225	19	four	four	NUM
biomedich-710	225	20	amino	amino	ADJ
biomedich-710	225	21	acids	acid	NOUN
biomedich-710	225	22	in	in	ADP
biomedich-710	225	23	the	the	DET
biomedich-710	225	24	active	active	ADJ
biomedich-710	225	25	site	site	NOUN
biomedich-710	225	26	(	(	PUNCT
biomedich-710	225	27	asn1042	asn1042	NOUN
biomedich-710	225	28	,	,	PUNCT
biomedich-710	225	29	gly1073	gly1073	NOUN
biomedich-710	225	30	,	,	PUNCT
biomedich-710	225	31	glu1046	glu1046	NOUN
biomedich-710	225	32	and	and	CCONJ
biomedich-710	225	33	val1039	val1039	NOUN
biomedich-710	225	34	)	)	PUNCT
biomedich-710	225	35	.	.	PUNCT
biomedich-710	226	1	lupeol	lupeol	NOUN
biomedich-710	226	2	,	,	PUNCT
biomedich-710	226	3	beta	beta	NOUN
biomedich-710	226	4	-	-	PUNCT
biomedich-710	226	5	sitosterol	sitosterol	NOUN
biomedich-710	226	6	and	and	CCONJ
biomedich-710	226	7	sanguinarine	sanguinarine	NOUN
biomedich-710	226	8	do	do	AUX
biomedich-710	226	9	not	not	PART
biomedich-710	226	10	form	form	VERB
biomedich-710	226	11	h	h	NOUN
biomedich-710	226	12	-	-	PUNCT
biomedich-710	226	13	bonds	bond	NOUN
biomedich-710	226	14	with	with	ADP
biomedich-710	226	15	the	the	DET
biomedich-710	226	16	topoisomerase	topoisomerase	NOUN
biomedich-710	226	17	iv	iv	NUM
biomedich-710	226	18	pare	pare	NOUN
biomedich-710	226	19	24kda	24kda	NOUN
biomedich-710	226	20	subunit	subunit	NOUN
biomedich-710	226	21	of	of	ADP
biomedich-710	226	22	e.	e.	PROPN
biomedich-710	226	23	coli	coli	PROPN
biomedich-710	226	24	,	,	PUNCT
biomedich-710	226	25	but	but	CCONJ
biomedich-710	226	26	they	they	PRON
biomedich-710	226	27	exhibit	exhibit	VERB
biomedich-710	226	28	hydrophobic	hydrophobic	NOUN
biomedich-710	226	29	interactions	interaction	NOUN
biomedich-710	226	30	with	with	ADP
biomedich-710	226	31	the	the	DET
biomedich-710	226	32	protein	protein	NOUN
biomedich-710	226	33	(	(	PUNCT
biomedich-710	226	34	figure	figure	NOUN
biomedich-710	226	35	4	4	NUM
biomedich-710	226	36	and	and	CCONJ
biomedich-710	226	37	table	table	NOUN
biomedich-710	226	38	6	6	NUM
biomedich-710	226	39	)	)	PUNCT
biomedich-710	226	40	.	.	PUNCT
biomedich-710	227	1	considering	consider	VERB
biomedich-710	227	2	the	the	DET
biomedich-710	227	3	h	h	NOUN
biomedich-710	227	4	-	-	PUNCT
biomedich-710	227	5	bonds	bond	NOUN
biomedich-710	227	6	between	between	ADP
biomedich-710	227	7	topoisomerase	topoisomerase	NOUN
biomedich-710	227	8	iv	iv	NUM
biomedich-710	227	9	pare	pare	NOUN
biomedich-710	227	10	24kda	24kda	NOUN
biomedich-710	227	11	subunit	subunit	NOUN
biomedich-710	227	12	of	of	ADP
biomedich-710	227	13	s.	s.	PROPN
biomedich-710	227	14	aureus	aureus	PROPN
biomedich-710	227	15	and	and	CCONJ
biomedich-710	227	16	novobiocin	novobiocin	PROPN
biomedich-710	227	17	,	,	PUNCT
biomedich-710	227	18	five	five	NUM
biomedich-710	227	19	hbonds	hbond	NOUN
biomedich-710	227	20	were	be	AUX
biomedich-710	227	21	observed	observe	VERB
biomedich-710	227	22	with	with	ADP
biomedich-710	227	23	five	five	NUM
biomedich-710	227	24	amino	amino	ADJ
biomedich-710	227	25	acids	acid	NOUN
biomedich-710	227	26	present	present	NOUN
biomedich-710	227	27	in	in	ADP
biomedich-710	227	28	the	the	DET
biomedich-710	227	29	active	active	ADJ
biomedich-710	227	30	site	site	NOUN
biomedich-710	227	31	(	(	PUNCT
biomedich-710	227	32	arg138	arg138	PROPN
biomedich-710	227	33	,	,	PUNCT
biomedich-710	227	34	thr92	thr92	NOUN
biomedich-710	227	35	,	,	PUNCT
biomedich-710	227	36	gly80	gly80	NOUN
biomedich-710	227	37	,	,	PUNCT
biomedich-710	227	38	glu53	glu53	NOUN
biomedich-710	227	39	and	and	CCONJ
biomedich-710	227	40	asp76	asp76	NOUN
biomedich-710	227	41	)	)	PUNCT
biomedich-710	227	42	.	.	PUNCT
biomedich-710	228	1	between	between	ADP
biomedich-710	228	2	quercetin	quercetin	NOUN
biomedich-710	228	3	and	and	CCONJ
biomedich-710	228	4	the	the	DET
biomedich-710	228	5	protein	protein	NOUN
biomedich-710	228	6	,	,	PUNCT
biomedich-710	228	7	five	five	NUM
biomedich-710	228	8	hbonds	hbond	NOUN
biomedich-710	228	9	with	with	ADP
biomedich-710	228	10	five	five	NUM
biomedich-710	228	11	amino	amino	ADJ
biomedich-710	228	12	acids	acid	NOUN
biomedich-710	228	13	present	present	NOUN
biomedich-710	228	14	on	on	ADP
biomedich-710	228	15	the	the	DET
biomedich-710	228	16	active	active	ADJ
biomedich-710	228	17	site	site	NOUN
biomedich-710	228	18	,	,	PUNCT
biomedich-710	228	19	were	be	AUX
biomedich-710	228	20	observed	observe	VERB
biomedich-710	228	21	(	(	PUNCT
biomedich-710	228	22	arg79	arg79	NOUN
biomedich-710	228	23	,	,	PUNCT
biomedich-710	228	24	gly80	gly80	NOUN
biomedich-710	228	25	,	,	PUNCT
biomedich-710	228	26	ile46	ile46	PROPN
biomedich-710	228	27	,	,	PUNCT
biomedich-710	228	28	asp76	asp76	NOUN
biomedich-710	228	29	,	,	PUNCT
biomedich-710	228	30	and	and	CCONJ
biomedich-710	228	31	glu53	glu53	PROPN
biomedich-710	228	32	)	)	PUNCT
biomedich-710	228	33	.	.	PUNCT
biomedich-710	229	1	kaempferol	kaempferol	PROPN
biomedich-710	229	2	shows	show	VERB
biomedich-710	229	3	four	four	NUM
biomedich-710	229	4	h	h	NOUN
biomedich-710	229	5	-	-	PUNCT
biomedich-710	229	6	bonds	bond	NOUN
biomedich-710	229	7	with	with	ADP
biomedich-710	229	8	the	the	DET
biomedich-710	229	9	protein	protein	NOUN
biomedich-710	229	10	(	(	PUNCT
biomedich-710	229	11	ser50	ser50	VERB
biomedich-710	229	12	,	,	PUNCT
biomedich-710	229	13	asn49	asn49	ADJ
biomedich-710	229	14	,	,	PUNCT
biomedich-710	229	15	asn56	asn56	NOUN
biomedich-710	229	16	,	,	PUNCT
biomedich-710	229	17	and	and	CCONJ
biomedich-710	229	18	gly80	gly80	NOUN
biomedich-710	229	19	)	)	PUNCT
biomedich-710	229	20	.	.	PUNCT
biomedich-710	230	1	three	three	NUM
biomedich-710	230	2	hbonds	hbond	NOUN
biomedich-710	230	3	were	be	AUX
biomedich-710	230	4	observed	observe	VERB
biomedich-710	230	5	between	between	ADP
biomedich-710	230	6	the	the	DET
biomedich-710	230	7	protein	protein	NOUN
biomedich-710	230	8	and	and	CCONJ
biomedich-710	230	9	naringenin	naringenin	PROPN
biomedich-710	230	10	(	(	PUNCT
biomedich-710	230	11	gly80	gly80	NOUN
biomedich-710	230	12	,	,	PUNCT
biomedich-710	230	13	asp76	asp76	NOUN
biomedich-710	230	14	,	,	PUNCT
biomedich-710	230	15	and	and	CCONJ
biomedich-710	230	16	thr168	thr168	NOUN
biomedich-710	230	17	)	)	PUNCT
biomedich-710	230	18	.	.	PUNCT
biomedich-710	231	1	the	the	DET
biomedich-710	231	2	highest	high	ADJ
biomedich-710	231	3	number	number	NOUN
biomedich-710	231	4	of	of	ADP
biomedich-710	231	5	h	h	NOUN
biomedich-710	231	6	-	-	PUNCT
biomedich-710	231	7	bonds	bond	NOUN
biomedich-710	231	8	observed	observe	VERB
biomedich-710	231	9	is	be	AUX
biomedich-710	231	10	six	six	NUM
biomedich-710	231	11	between	between	ADP
biomedich-710	231	12	isoquercetin	isoquercetin	NOUN
biomedich-710	231	13	and	and	CCONJ
biomedich-710	231	14	the	the	DET
biomedich-710	231	15	protein	protein	NOUN
biomedich-710	231	16	(	(	PUNCT
biomedich-710	231	17	asn49	asn49	PROPN
biomedich-710	231	18	,	,	PUNCT
biomedich-710	231	19	asn56	asn56	PROPN
biomedich-710	231	20	,	,	PUNCT
biomedich-710	231	21	glu53	glu53	NOUN
biomedich-710	231	22	,	,	PUNCT
biomedich-710	231	23	and	and	CCONJ
biomedich-710	231	24	asp76	asp76	NOUN
biomedich-710	231	25	)	)	PUNCT
biomedich-710	231	26	.	.	PUNCT
biomedich-710	232	1	sanguinarine	sanguinarine	PROPN
biomedich-710	232	2	exhibits	exhibit	VERB
biomedich-710	232	3	one	one	NUM
biomedich-710	232	4	h	h	NOUN
biomedich-710	232	5	-	-	PUNCT
biomedich-710	232	6	bond	bond	NOUN
biomedich-710	232	7	with	with	ADP
biomedich-710	232	8	the	the	DET
biomedich-710	232	9	protein	protein	NOUN
biomedich-710	232	10	(	(	PUNCT
biomedich-710	232	11	arg79	arg79	PROPN
biomedich-710	232	12	)	)	PUNCT
biomedich-710	232	13	.	.	PUNCT
biomedich-710	233	1	both	both	PRON
biomedich-710	233	2	lupeol	lupeol	VERB
biomedich-710	233	3	and	and	CCONJ
biomedich-710	233	4	beta	beta	NOUN
biomedich-710	233	5	-	-	PUNCT
biomedich-710	233	6	sitosterol	sitosterol	NOUN
biomedich-710	233	7	show	show	VERB
biomedich-710	233	8	hydrophilic	hydrophilic	ADJ
biomedich-710	233	9	interactions	interaction	NOUN
biomedich-710	233	10	with	with	ADP
biomedich-710	233	11	the	the	DET
biomedich-710	233	12	protein	protein	NOUN
biomedich-710	233	13	but	but	CCONJ
biomedich-710	233	14	do	do	AUX
biomedich-710	233	15	not	not	PART
biomedich-710	233	16	form	form	VERB
biomedich-710	233	17	any	any	DET
biomedich-710	233	18	h	h	NOUN
biomedich-710	233	19	-	-	PUNCT
biomedich-710	233	20	bonds	bond	NOUN
biomedich-710	233	21	(	(	PUNCT
biomedich-710	233	22	figure	figure	NOUN
biomedich-710	233	23	5	5	NUM
biomedich-710	233	24	and	and	CCONJ
biomedich-710	233	25	table	table	NOUN
biomedich-710	233	26	7	7	NUM
biomedich-710	233	27	)	)	PUNCT
biomedich-710	233	28	.	.	PUNCT
biomedich-710	234	1	considering	consider	VERB
biomedich-710	234	2	the	the	DET
biomedich-710	234	3	predicted	predict	VERB
biomedich-710	234	4	physiochemical	physiochemical	ADJ
biomedich-710	234	5	properties	property	NOUN
biomedich-710	234	6	of	of	ADP
biomedich-710	234	7	selected	select	VERB
biomedich-710	234	8	molecules	molecule	NOUN
biomedich-710	234	9	,	,	PUNCT
biomedich-710	234	10	isoquercetin	isoquercetin	NOUN
biomedich-710	234	11	and	and	CCONJ
biomedich-710	234	12	rutin	rutin	NOUN
biomedich-710	234	13	do	do	AUX
biomedich-710	234	14	not	not	PART
biomedich-710	234	15	fulfil	fulfil	VERB
biomedich-710	234	16	lipinski	lipinski	PROPN
biomedich-710	234	17	’s	’s	PART
biomedich-710	234	18	and	and	CCONJ
biomedich-710	234	19	veber	veber	PROPN
biomedich-710	234	20	’s	’s	PART
biomedich-710	234	21	rules	rule	NOUN
biomedich-710	234	22	.	.	PUNCT
biomedich-710	235	1	even	even	ADV
biomedich-710	235	2	novobiocin	novobiocin	ADJ
biomedich-710	235	3	,	,	PUNCT
biomedich-710	235	4	a	a	DET
biomedich-710	235	5	commercially	commercially	ADV
biomedich-710	235	6	available	available	ADJ
biomedich-710	235	7	antibiotic	antibiotic	NOUN
biomedich-710	235	8	,	,	PUNCT
biomedich-710	235	9	does	do	AUX
biomedich-710	235	10	not	not	PART
biomedich-710	235	11	fulfil	fulfil	VERB
biomedich-710	235	12	lipinski	lipinski	PROPN
biomedich-710	235	13	’s	’s	PART
biomedich-710	235	14	and	and	CCONJ
biomedich-710	235	15	veber	veber	PROPN
biomedich-710	235	16	’s	’s	PART
biomedich-710	235	17	rules	rule	NOUN
biomedich-710	235	18	.	.	PUNCT
biomedich-710	236	1	except	except	SCONJ
biomedich-710	236	2	for	for	ADP
biomedich-710	236	3	sanguinarine	sanguinarine	NOUN
biomedich-710	236	4	,	,	PUNCT
biomedich-710	236	5	none	none	NOUN
biomedich-710	236	6	penetrates	penetrate	VERB
biomedich-710	236	7	the	the	DET
biomedich-710	236	8	blood	blood	NOUN
biomedich-710	236	9	brain	brain	NOUN
biomedich-710	236	10	barrier	barrier	NOUN
biomedich-710	236	11	(	(	PUNCT
biomedich-710	236	12	bbb	bbb	PROPN
biomedich-710	236	13	)	)	PUNCT
biomedich-710	236	14	.	.	PUNCT
biomedich-710	237	1	oral	oral	ADJ
biomedich-710	237	2	rat	rat	NOUN
biomedich-710	237	3	acute	acute	NOUN
biomedich-710	237	4	toxicity	toxicity	NOUN
biomedich-710	237	5	(	(	PUNCT
biomedich-710	237	6	ld50	ld50	PROPN
biomedich-710	237	7	)	)	PUNCT
biomedich-710	237	8	is	be	AUX
biomedich-710	237	9	defined	define	VERB
biomedich-710	237	10	as	as	ADP
biomedich-710	237	11	the	the	DET
biomedich-710	237	12	amount	amount	NOUN
biomedich-710	237	13	of	of	ADP
biomedich-710	237	14	substance	substance	NOUN
biomedich-710	237	15	that	that	PRON
biomedich-710	237	16	is	be	AUX
biomedich-710	237	17	required	require	VERB
biomedich-710	237	18	to	to	PART
biomedich-710	237	19	kill	kill	VERB
biomedich-710	237	20	50	50	NUM
biomedich-710	237	21	%	%	NOUN
biomedich-710	237	22	of	of	ADP
biomedich-710	237	23	a	a	DET
biomedich-710	237	24	tested	test	VERB
biomedich-710	237	25	population	population	NOUN
biomedich-710	237	26	within	within	ADP
biomedich-710	237	27	a	a	DET
biomedich-710	237	28	specific	specific	ADJ
biomedich-710	237	29	time	time	NOUN
biomedich-710	237	30	frame	frame	NOUN
biomedich-710	237	31	.	.	PUNCT
biomedich-710	238	1	among	among	ADP
biomedich-710	238	2	the	the	DET
biomedich-710	238	3	selected	select	VERB
biomedich-710	238	4	molecules	molecule	NOUN
biomedich-710	238	5	,	,	PUNCT
biomedich-710	238	6	all	all	PRON
biomedich-710	238	7	except	except	SCONJ
biomedich-710	238	8	naringenin	naringenin	NOUN
biomedich-710	238	9	exhibit	exhibit	VERB
biomedich-710	238	10	higher	high	ADJ
biomedich-710	238	11	ld50	ld50	PROPN
biomedich-710	238	12	values	value	NOUN
biomedich-710	238	13	compared	compare	VERB
biomedich-710	238	14	to	to	ADP
biomedich-710	238	15	commercially	commercially	ADV
biomedich-710	238	16	available	available	ADJ
biomedich-710	238	17	antibiotics	antibiotic	NOUN
biomedich-710	238	18	which	which	PRON
biomedich-710	238	19	are	be	AUX
biomedich-710	238	20	penicillin	penicillin	NOUN
biomedich-710	238	21	and	and	CCONJ
biomedich-710	238	22	novobiocin	novobiocin	NOUN
biomedich-710	238	23	.	.	PUNCT
biomedich-710	239	1	a	a	DET
biomedich-710	239	2	higher	high	ADJ
biomedich-710	239	3	ld50	ld50	PROPN
biomedich-710	239	4	value	value	NOUN
biomedich-710	239	5	suggests	suggest	VERB
biomedich-710	239	6	that	that	SCONJ
biomedich-710	239	7	these	these	DET
biomedich-710	239	8	molecules	molecule	NOUN
biomedich-710	239	9	may	may	AUX
biomedich-710	239	10	be	be	AUX
biomedich-710	239	11	less	less	ADV
biomedich-710	239	12	toxic	toxic	ADJ
biomedich-710	239	13	than	than	ADP
biomedich-710	239	14	penicillin	penicillin	NOUN
biomedich-710	239	15	and	and	CCONJ
biomedich-710	239	16	novobiocin	novobiocin	NOUN
biomedich-710	239	17	.	.	PUNCT
biomedich-710	240	1	hepatotoxicity	hepatotoxicity	NOUN
biomedich-710	240	2	which	which	PRON
biomedich-710	240	3	is	be	AUX
biomedich-710	240	4	also	also	ADV
biomedich-710	240	5	known	know	VERB
biomedich-710	240	6	as	as	ADP
biomedich-710	240	7	liver	liver	NOUN
biomedich-710	240	8	toxicity	toxicity	NOUN
biomedich-710	240	9	of	of	ADP
biomedich-710	240	10	the	the	DET
biomedich-710	240	11	selected	select	VERB
biomedich-710	240	12	molecules	molecule	NOUN
biomedich-710	240	13	was	be	AUX
biomedich-710	240	14	also	also	ADV
biomedich-710	240	15	evaluated	evaluate	VERB
biomedich-710	240	16	.	.	PUNCT
biomedich-710	241	1	all	all	DET
biomedich-710	241	2	the	the	DET
biomedich-710	241	3	molecules	molecule	NOUN
biomedich-710	241	4	,	,	PUNCT
biomedich-710	241	5	except	except	SCONJ
biomedich-710	241	6	penicillin	penicillin	NOUN
biomedich-710	241	7	,	,	PUNCT
biomedich-710	241	8	were	be	AUX
biomedich-710	241	9	found	find	VERB
biomedich-710	241	10	to	to	PART
biomedich-710	241	11	be	be	AUX
biomedich-710	241	12	non	non	ADJ
biomedich-710	241	13	-	-	ADJ
biomedich-710	241	14	hepatotoxic	hepatotoxic	ADJ
biomedich-710	241	15	.	.	PUNCT
biomedich-710	242	1	when	when	SCONJ
biomedich-710	242	2	considering	consider	VERB
biomedich-710	242	3	the	the	DET
biomedich-710	242	4	number	number	NOUN
biomedich-710	242	5	of	of	ADP
biomedich-710	242	6	selected	select	VERB
biomedich-710	242	7	molecules	molecule	NOUN
biomedich-710	242	8	that	that	PRON
biomedich-710	242	9	exhibit	exhibit	VERB
biomedich-710	242	10	higher	high	ADJ
biomedich-710	242	11	binding	bind	VERB
biomedich-710	242	12	affinity	affinity	NOUN
biomedich-710	242	13	to	to	ADP
biomedich-710	242	14	the	the	DET
biomedich-710	242	15	protein	protein	NOUN
biomedich-710	242	16	than	than	ADP
biomedich-710	242	17	the	the	DET
biomedich-710	242	18	reference	reference	NOUN
biomedich-710	242	19	molecule	molecule	NOUN
biomedich-710	242	20	,	,	PUNCT
biomedich-710	242	21	only	only	ADV
biomedich-710	242	22	two	two	NUM
biomedich-710	242	23	molecules	molecule	NOUN
biomedich-710	242	24	(	(	PUNCT
biomedich-710	242	25	lupeol	lupeol	NOUN
biomedich-710	242	26	and	and	CCONJ
biomedich-710	242	27	beta	beta	NOUN
biomedich-710	242	28	-	-	PUNCT
biomedich-710	242	29	sitosterol	sitosterol	NOUN
biomedich-710	242	30	)	)	PUNCT
biomedich-710	242	31	exhibit	exhibit	VERB
biomedich-710	242	32	higher	high	ADJ
biomedich-710	242	33	binding	bind	VERB
biomedich-710	242	34	affinity	affinity	NOUN
biomedich-710	242	35	than	than	ADP
biomedich-710	242	36	penicillin	penicillin	PROPN
biomedich-710	242	37	against	against	ADP
biomedich-710	242	38	pbp	pbp	PROPN
biomedich-710	242	39	5	5	NUM
biomedich-710	242	40	of	of	ADP
biomedich-710	242	41	e.	e.	PROPN
biomedich-710	242	42	coli	coli	PROPN
biomedich-710	242	43	.	.	PUNCT
biomedich-710	243	1	in	in	ADP
biomedich-710	243	2	the	the	DET
biomedich-710	243	3	case	case	NOUN
biomedich-710	243	4	of	of	ADP
biomedich-710	243	5	topoisomerase	topoisomerase	NOUN
biomedich-710	243	6	iv	iv	NUM
biomedich-710	243	7	pare	pare	NOUN
biomedich-710	243	8	24kda	24kda	NOUN
biomedich-710	243	9	subunit	subunit	NOUN
biomedich-710	243	10	,	,	PUNCT
biomedich-710	243	11	seven	seven	NUM
biomedich-710	243	12	molecules	molecule	NOUN
biomedich-710	243	13	exhibit	exhibit	VERB
biomedich-710	243	14	higher	high	ADJ
biomedich-710	243	15	binding	bind	VERB
biomedich-710	243	16	affinity	affinity	NOUN
biomedich-710	243	17	compared	compare	VERB
biomedich-710	243	18	to	to	ADP
biomedich-710	243	19	the	the	DET
biomedich-710	243	20	reference	reference	NOUN
biomedich-710	243	21	molecule	molecule	NOUN
biomedich-710	243	22	which	which	PRON
biomedich-710	243	23	is	be	AUX
biomedich-710	243	24	novobiocin	novobiocin	ADJ
biomedich-710	243	25	in	in	ADP
biomedich-710	243	26	both	both	DET
biomedich-710	243	27	e.	e.	PROPN
biomedich-710	243	28	coli	coli	PROPN
biomedich-710	243	29	and	and	CCONJ
biomedich-710	243	30	s.	s.	PROPN
biomedich-710	243	31	aureus	aureus	PROPN
biomedich-710	243	32	.	.	PUNCT
biomedich-710	244	1	further	further	ADJ
biomedich-710	244	2	studies	study	NOUN
biomedich-710	244	3	should	should	AUX
biomedich-710	244	4	be	be	AUX
biomedich-710	244	5	conducted	conduct	VERB
biomedich-710	244	6	to	to	PART
biomedich-710	244	7	investigate	investigate	VERB
biomedich-710	244	8	the	the	DET
biomedich-710	244	9	combined	combined	ADJ
biomedich-710	244	10	effect	effect	NOUN
biomedich-710	244	11	of	of	ADP
biomedich-710	244	12	the	the	DET
biomedich-710	244	13	molecules	molecule	NOUN
biomedich-710	244	14	against	against	ADP
biomedich-710	244	15	each	each	DET
biomedich-710	244	16	protein	protein	NOUN
biomedich-710	244	17	.	.	PUNCT
biomedich-710	245	1	these	these	DET
biomedich-710	245	2	results	result	NOUN
biomedich-710	245	3	reveal	reveal	VERB
biomedich-710	245	4	that	that	SCONJ
biomedich-710	245	5	selected	select	VERB
biomedich-710	245	6	phytochemicals	phytochemical	NOUN
biomedich-710	245	7	show	show	VERB
biomedich-710	245	8	a	a	DET
biomedich-710	245	9	higher	high	ADJ
biomedich-710	245	10	inhibitory	inhibitory	ADJ
biomedich-710	245	11	effect	effect	NOUN
biomedich-710	245	12	on	on	ADP
biomedich-710	245	13	the	the	DET
biomedich-710	245	14	dna	dna	PROPN
biomedich-710	245	15	topoisomerase	topoisomerase	NOUN
biomedich-710	245	16	iv	iv	NUM
biomedich-710	245	17	pare	pare	NOUN
biomedich-710	245	18	24kda	24kda	NOUN
biomedich-710	245	19	subunit	subunit	NOUN
biomedich-710	245	20	compared	compare	VERB
biomedich-710	245	21	to	to	ADP
biomedich-710	245	22	their	their	PRON
biomedich-710	245	23	effect	effect	NOUN
biomedich-710	245	24	on	on	ADP
biomedich-710	245	25	pbp5	pbp5	PROPN
biomedich-710	245	26	.	.	PUNCT
biomedich-710	246	1	this	this	PRON
biomedich-710	246	2	suggests	suggest	VERB
biomedich-710	246	3	that	that	SCONJ
biomedich-710	246	4	selected	select	VERB
biomedich-710	246	5	molecules	molecule	NOUN
biomedich-710	246	6	may	may	AUX
biomedich-710	246	7	inhibit	inhibit	VERB
biomedich-710	246	8	enzymes	enzyme	NOUN
biomedich-710	246	9	crucial	crucial	ADJ
biomedich-710	246	10	to	to	ADP
biomedich-710	246	11	bacterial	bacterial	ADJ
biomedich-710	246	12	structural	structural	ADJ
biomedich-710	246	13	component	component	NOUN
biomedich-710	246	14	synthesis	synthesis	NOUN
biomedich-710	246	15	and	and	CCONJ
biomedich-710	246	16	dna	dna	NOUN
biomedich-710	246	17	replication	replication	NOUN
biomedich-710	246	18	.	.	PUNCT
biomedich-710	247	1	these	these	DET
biomedich-710	247	2	molecules	molecule	NOUN
biomedich-710	247	3	may	may	AUX
biomedich-710	247	4	exhibit	exhibit	VERB
biomedich-710	247	5	a	a	DET
biomedich-710	247	6	dual	dual	ADJ
biomedich-710	247	7	mechanism	mechanism	NOUN
biomedich-710	247	8	of	of	ADP
biomedich-710	247	9	action	action	NOUN
biomedich-710	247	10	.	.	PUNCT
biomedich-710	248	1	this	this	DET
biomedich-710	248	2	dual	dual	ADJ
biomedich-710	248	3	action	action	NOUN
biomedich-710	248	4	mechanism	mechanism	NOUN
biomedich-710	248	5	may	may	AUX
biomedich-710	248	6	potentially	potentially	ADV
biomedich-710	248	7	kill	kill	VERB
biomedich-710	248	8	or	or	CCONJ
biomedich-710	248	9	reduce	reduce	VERB
biomedich-710	248	10	the	the	DET
biomedich-710	248	11	growth	growth	NOUN
biomedich-710	248	12	of	of	ADP
biomedich-710	248	13	microorganisms	microorganism	NOUN
biomedich-710	248	14	.	.	PUNCT
biomedich-710	249	1	the	the	DET
biomedich-710	249	2	re	re	NOUN
biomedich-710	249	3	-	-	NOUN
biomedich-710	249	4	docking	docking	ADJ
biomedich-710	249	5	was	be	AUX
biomedich-710	249	6	done	do	VERB
biomedich-710	249	7	to	to	PART
biomedich-710	249	8	validate	validate	VERB
biomedich-710	249	9	the	the	DET
biomedich-710	249	10	docking	docking	NOUN
biomedich-710	249	11	procedure	procedure	NOUN
biomedich-710	249	12	.	.	PUNCT
biomedich-710	250	1	penicillin	penicillin	PROPN
biomedich-710	250	2	bound	bind	VERB
biomedich-710	250	3	to	to	ADP
biomedich-710	250	4	the	the	DET
biomedich-710	250	5	active	active	ADJ
biomedich-710	250	6	site	site	NOUN
biomedich-710	250	7	of	of	ADP
biomedich-710	250	8	the	the	DET
biomedich-710	250	9	penicillin	penicillin	NOUN
biomedich-710	250	10	-	-	PUNCT
biomedich-710	250	11	binding	bind	VERB
biomedich-710	250	12	protein	protein	NOUN
biomedich-710	250	13	5	5	NUM
biomedich-710	250	14	of	of	ADP
biomedich-710	250	15	e.	e.	PROPN
biomedich-710	250	16	coli	coli	PROPN
biomedich-710	250	17	with	with	ADP
biomedich-710	250	18	binding	bind	VERB
biomedich-710	250	19	energy	energy	NOUN
biomedich-710	250	20	of	of	ADP
biomedich-710	250	21	-7.20	-7.20	X
biomedich-710	250	22	kcal	kcal	NOUN
biomedich-710	250	23	/	/	SYM
biomedich-710	250	24	mol	mol	PROPN
biomedich-710	250	25	.	.	PROPN
biomedich-710	251	1	penicillin	penicillin	PROPN
biomedich-710	251	2	formed	form	VERB
biomedich-710	251	3	three	three	NUM
biomedich-710	251	4	hbonds	hbond	NOUN
biomedich-710	251	5	with	with	ADP
biomedich-710	251	6	three	three	NUM
biomedich-710	251	7	amino	amino	ADJ
biomedich-710	251	8	acids	acid	NOUN
biomedich-710	251	9	(	(	PUNCT
biomedich-710	251	10	ser44	ser44	NOUN
biomedich-710	251	11	,	,	PUNCT
biomedich-710	251	12	ser87	ser87	NOUN
biomedich-710	251	13	,	,	PUNCT
biomedich-710	251	14	and	and	CCONJ
biomedich-710	251	15	asn112	asn112	PROPN
biomedich-710	251	16	)	)	PUNCT
biomedich-710	251	17	located	locate	VERB
biomedich-710	251	18	in	in	ADP
biomedich-710	251	19	the	the	DET
biomedich-710	251	20	active	active	ADJ
biomedich-710	251	21	site	site	NOUN
biomedich-710	251	22	of	of	ADP
biomedich-710	251	23	the	the	DET
biomedich-710	251	24	pbp	pbp	PROPN
biomedich-710	251	25	5	5	NUM
biomedich-710	251	26	of	of	ADP
biomedich-710	251	27	e.	e.	PROPN
biomedich-710	251	28	coli	coli	PROPN
biomedich-710	251	29	with	with	ADP
biomedich-710	251	30	a	a	DET
biomedich-710	251	31	distance	distance	NOUN
biomedich-710	251	32	ranging	range	VERB
biomedich-710	251	33	from	from	ADP
biomedich-710	251	34	1.7	1.7	NUM
biomedich-710	251	35	–	–	PUNCT
biomedich-710	251	36	2.1	2.1	NUM
biomedich-710	251	37	a0	a0	NOUN
biomedich-710	251	38	.	.	PUNCT
biomedich-710	252	1	these	these	DET
biomedich-710	252	2	bonds	bond	NOUN
biomedich-710	252	3	are	be	AUX
biomedich-710	252	4	well	well	ADV
biomedich-710	252	5	within	within	ADP
biomedich-710	252	6	the	the	DET
biomedich-710	252	7	optimal	optimal	ADJ
biomedich-710	252	8	range	range	NOUN
biomedich-710	252	9	for	for	ADP
biomedich-710	252	10	h	h	NOUN
biomedich-710	252	11	-	-	PUNCT
biomedich-710	252	12	bonding	bonding	NOUN
biomedich-710	252	13	,	,	PUNCT
biomedich-710	252	14	indicating	indicate	VERB
biomedich-710	252	15	a	a	DET
biomedich-710	252	16	strong	strong	ADJ
biomedich-710	252	17	interaction	interaction	NOUN
biomedich-710	252	18	.	.	PUNCT
biomedich-710	253	1	the	the	DET
biomedich-710	253	2	re	re	ADJ
biomedich-710	253	3	-	-	ADJ
biomedich-710	253	4	docked	docked	ADJ
biomedich-710	253	5	complex	complex	ADJ
biomedich-710	253	6	isuranga	isuranga	NOUN
biomedich-710	253	7	&	&	CCONJ
biomedich-710	253	8	danthanarayana	danthanarayana	PROPN
biomedich-710	253	9	–	–	PUNCT
biomedich-710	253	10	antimicrobial	antimicrobial	ADJ
biomedich-710	253	11	potential	potential	NOUN
biomedich-710	253	12	of	of	ADP
biomedich-710	253	13	phytochemicals	phytochemical	NOUN
biomedich-710	253	14	from	from	ADP
biomedich-710	253	15	coccinia	coccinia	NOUN
biomedich-710	253	16	grandis	grandis	NOUN
biomedich-710	253	17	…	…	PUNCT
biomedich-710	253	18	551	551	NUM
biomedich-710	253	19	was	be	AUX
biomedich-710	253	20	then	then	ADV
biomedich-710	253	21	superimposed	superimpose	VERB
biomedich-710	253	22	on	on	ADP
biomedich-710	253	23	to	to	ADP
biomedich-710	253	24	the	the	DET
biomedich-710	253	25	native	native	ADJ
biomedich-710	253	26	crystalized	crystalize	VERB
biomedich-710	253	27	structure	structure	NOUN
biomedich-710	253	28	of	of	ADP
biomedich-710	253	29	e.	e.	PROPN
biomedich-710	253	30	coli	coli	PROPN
biomedich-710	253	31	pbp	pbp	NOUN
biomedich-710	253	32	5	5	NUM
biomedich-710	253	33	from	from	ADP
biomedich-710	253	34	pdb	pdb	PROPN
biomedich-710	253	35	using	use	VERB
biomedich-710	253	36	pymol	pymol	NOUN
biomedich-710	253	37	observed	observe	VERB
biomedich-710	253	38	0.000	0.000	NUM
biomedich-710	253	39	a0	a0	NOUN
biomedich-710	253	40	rmsd	rmsd	NOUN
biomedich-710	253	41	value	value	NOUN
biomedich-710	253	42	.	.	PUNCT
biomedich-710	254	1	the	the	DET
biomedich-710	254	2	same	same	ADJ
biomedich-710	254	3	methodology	methodology	NOUN
biomedich-710	254	4	was	be	AUX
biomedich-710	254	5	followed	follow	VERB
biomedich-710	254	6	for	for	ADP
biomedich-710	254	7	both	both	CCONJ
biomedich-710	254	8	topoisomerase	topoisomerase	NOUN
biomedich-710	254	9	iv	iv	NUM
biomedich-710	254	10	pare	pare	NOUN
biomedich-710	254	11	24kda	24kda	NOUN
biomedich-710	254	12	subunit	subunit	NOUN
biomedich-710	254	13	of	of	ADP
biomedich-710	254	14	e.	e.	PROPN
biomedich-710	254	15	coli	coli	PROPN
biomedich-710	254	16	and	and	CCONJ
biomedich-710	254	17	s.	s.	PROPN
biomedich-710	254	18	aureus	aureus	PROPN
biomedich-710	254	19	with	with	ADP
biomedich-710	254	20	novobiocin	novobiocin	PROPN
biomedich-710	254	21	.	.	PUNCT
biomedich-710	255	1	novobiocin	novobiocin	PROPN
biomedich-710	255	2	formed	form	VERB
biomedich-710	255	3	two	two	NUM
biomedich-710	255	4	h	h	NOUN
biomedich-710	255	5	-	-	PUNCT
biomedich-710	255	6	bonds	bond	NOUN
biomedich-710	255	7	with	with	ADP
biomedich-710	255	8	two	two	NUM
biomedich-710	255	9	amino	amino	ADJ
biomedich-710	255	10	acids	acid	NOUN
biomedich-710	255	11	(	(	PUNCT
biomedich-710	255	12	his1079	his1079	NOUN
biomedich-710	255	13	and	and	CCONJ
biomedich-710	255	14	ile1078	ile1078	NOUN
biomedich-710	255	15	)	)	PUNCT
biomedich-710	255	16	located	locate	VERB
biomedich-710	255	17	in	in	ADP
biomedich-710	255	18	the	the	DET
biomedich-710	255	19	active	active	ADJ
biomedich-710	255	20	site	site	NOUN
biomedich-710	255	21	of	of	ADP
biomedich-710	255	22	the	the	DET
biomedich-710	255	23	topoisomerase	topoisomerase	NOUN
biomedich-710	255	24	iv	iv	NUM
biomedich-710	255	25	pare	pare	NOUN
biomedich-710	255	26	24kda	24kda	NOUN
biomedich-710	255	27	subunit	subunit	NOUN
biomedich-710	255	28	of	of	ADP
biomedich-710	255	29	e.	e.	PROPN
biomedich-710	255	30	coli	coli	PROPN
biomedich-710	255	31	with	with	ADP
biomedich-710	255	32	a	a	DET
biomedich-710	255	33	distance	distance	NOUN
biomedich-710	255	34	ranging	range	VERB
biomedich-710	255	35	from	from	ADP
biomedich-710	255	36	2.4	2.4	NUM
biomedich-710	255	37	–	–	SYM
biomedich-710	255	38	2.9	2.9	NUM
biomedich-710	255	39	a0	a0	PROPN
biomedich-710	255	40	.	.	PUNCT
biomedich-710	256	1	novobiocin	novobiocin	PROPN
biomedich-710	256	2	formed	form	VERB
biomedich-710	256	3	five	five	NUM
biomedich-710	256	4	h	h	NOUN
biomedich-710	256	5	-	-	PUNCT
biomedich-710	256	6	bonds	bond	NOUN
biomedich-710	256	7	with	with	ADP
biomedich-710	256	8	five	five	NUM
biomedich-710	256	9	amino	amino	ADJ
biomedich-710	256	10	acids	acid	NOUN
biomedich-710	256	11	(	(	PUNCT
biomedich-710	256	12	arg138	arg138	PROPN
biomedich-710	256	13	,	,	PUNCT
biomedich-710	256	14	thr92	thr92	NOUN
biomedich-710	256	15	,	,	PUNCT
biomedich-710	256	16	gly80	gly80	NOUN
biomedich-710	256	17	,	,	PUNCT
biomedich-710	256	18	glu53	glu53	NOUN
biomedich-710	256	19	,	,	PUNCT
biomedich-710	256	20	and	and	CCONJ
biomedich-710	256	21	asp76	asp76	NOUN
biomedich-710	256	22	)	)	PUNCT
biomedich-710	256	23	located	locate	VERB
biomedich-710	256	24	in	in	ADP
biomedich-710	256	25	the	the	DET
biomedich-710	256	26	active	active	ADJ
biomedich-710	256	27	site	site	NOUN
biomedich-710	256	28	of	of	ADP
biomedich-710	256	29	the	the	DET
biomedich-710	256	30	topoisomerase	topoisomerase	NOUN
biomedich-710	256	31	iv	iv	NUM
biomedich-710	256	32	pare	pare	NOUN
biomedich-710	256	33	24kda	24kda	NOUN
biomedich-710	256	34	subunit	subunit	NOUN
biomedich-710	256	35	of	of	ADP
biomedich-710	256	36	s.	s.	PROPN
biomedich-710	256	37	aureus	aureus	PROPN
biomedich-710	256	38	with	with	ADP
biomedich-710	256	39	a	a	DET
biomedich-710	256	40	distance	distance	NOUN
biomedich-710	256	41	ranging	range	VERB
biomedich-710	256	42	from	from	ADP
biomedich-710	256	43	1.8	1.8	NUM
biomedich-710	256	44	–	–	SYM
biomedich-710	256	45	2.4	2.4	NUM
biomedich-710	256	46	a0	a0	NOUN
biomedich-710	256	47	.	.	PUNCT
biomedich-710	257	1	these	these	DET
biomedich-710	257	2	bonds	bond	NOUN
biomedich-710	257	3	are	be	AUX
biomedich-710	257	4	well	well	ADV
biomedich-710	257	5	within	within	ADP
biomedich-710	257	6	the	the	DET
biomedich-710	257	7	optimal	optimal	ADJ
biomedich-710	257	8	range	range	NOUN
biomedich-710	257	9	for	for	ADP
biomedich-710	257	10	h	h	NOUN
biomedich-710	257	11	-	-	PUNCT
biomedich-710	257	12	bonding	bonding	NOUN
biomedich-710	257	13	,	,	PUNCT
biomedich-710	257	14	indicating	indicate	VERB
biomedich-710	257	15	a	a	DET
biomedich-710	257	16	strong	strong	ADJ
biomedich-710	257	17	interaction	interaction	NOUN
biomedich-710	257	18	.	.	PUNCT
biomedich-710	258	1	the	the	DET
biomedich-710	258	2	re	re	ADJ
biomedich-710	258	3	-	-	ADJ
biomedich-710	258	4	docked	docked	ADJ
biomedich-710	258	5	complexes	complex	NOUN
biomedich-710	258	6	were	be	AUX
biomedich-710	258	7	then	then	ADV
biomedich-710	258	8	superimposed	superimpose	VERB
biomedich-710	258	9	on	on	ADP
biomedich-710	258	10	to	to	ADP
biomedich-710	258	11	their	their	PRON
biomedich-710	258	12	native	native	ADJ
biomedich-710	258	13	crystalized	crystalize	VERB
biomedich-710	258	14	structures	structure	NOUN
biomedich-710	258	15	using	use	VERB
biomedich-710	258	16	pymol	pymol	NOUN
biomedich-710	258	17	and	and	CCONJ
biomedich-710	258	18	observed	observe	VERB
biomedich-710	258	19	0.000	0.000	NUM
biomedich-710	258	20	a0	a0	NOUN
biomedich-710	258	21	rmsd	rmsd	NOUN
biomedich-710	258	22	value	value	NOUN
biomedich-710	258	23	(	(	PUNCT
biomedich-710	258	24	figure	figure	NOUN
biomedich-710	258	25	2	2	NUM
biomedich-710	258	26	)	)	PUNCT
biomedich-710	258	27	.	.	PUNCT
biomedich-710	259	1	obtaining	obtain	VERB
biomedich-710	259	2	0.000	0.000	NUM
biomedich-710	259	3	a0	a0	NOUN
biomedich-710	259	4	for	for	ADP
biomedich-710	259	5	rmsd	rmsd	NOUN
biomedich-710	259	6	indicates	indicate	VERB
biomedich-710	259	7	no	no	DET
biomedich-710	259	8	difference	difference	NOUN
biomedich-710	259	9	between	between	ADP
biomedich-710	259	10	the	the	DET
biomedich-710	259	11	re	re	ADJ
biomedich-710	259	12	-	-	ADJ
biomedich-710	259	13	docked	docked	ADJ
biomedich-710	259	14	complex	complex	NOUN
biomedich-710	259	15	and	and	CCONJ
biomedich-710	259	16	the	the	DET
biomedich-710	259	17	referenced	reference	VERB
biomedich-710	259	18	crystallized	crystallized	ADJ
biomedich-710	259	19	structure	structure	NOUN
biomedich-710	259	20	.	.	PUNCT
biomedich-710	260	1	overall	overall	ADV
biomedich-710	260	2	,	,	PUNCT
biomedich-710	260	3	this	this	DET
biomedich-710	260	4	study	study	NOUN
biomedich-710	260	5	provides	provide	VERB
biomedich-710	260	6	a	a	DET
biomedich-710	260	7	strong	strong	ADJ
biomedich-710	260	8	foundation	foundation	NOUN
biomedich-710	260	9	for	for	ADP
biomedich-710	260	10	further	further	ADJ
biomedich-710	260	11	investigations	investigation	NOUN
biomedich-710	260	12	to	to	PART
biomedich-710	260	13	study	study	VERB
biomedich-710	260	14	anti	anti	ADJ
biomedich-710	260	15	-	-	ADJ
biomedich-710	260	16	microbial	microbial	ADJ
biomedich-710	260	17	activity	activity	NOUN
biomedich-710	260	18	of	of	ADP
biomedich-710	260	19	selected	select	VERB
biomedich-710	260	20	molecules	molecule	NOUN
biomedich-710	260	21	derived	derive	VERB
biomedich-710	260	22	from	from	ADP
biomedich-710	260	23	phytochemicals	phytochemical	NOUN
biomedich-710	260	24	of	of	ADP
biomedich-710	260	25	coccinia	coccinia	NOUN
biomedich-710	260	26	grandis	grandis	PROPN
biomedich-710	260	27	leaves	leave	VERB
biomedich-710	260	28	.	.	PUNCT
biomedich-710	261	1	these	these	DET
biomedich-710	261	2	findings	finding	NOUN
biomedich-710	261	3	may	may	AUX
biomedich-710	261	4	pave	pave	VERB
biomedich-710	261	5	the	the	DET
biomedich-710	261	6	way	way	NOUN
biomedich-710	261	7	for	for	ADP
biomedich-710	261	8	developing	develop	VERB
biomedich-710	261	9	novel	novel	ADJ
biomedich-710	261	10	antibiotic	antibiotic	ADJ
biomedich-710	261	11	agents	agent	NOUN
biomedich-710	261	12	with	with	ADP
biomedich-710	261	13	enhanced	enhanced	ADJ
biomedich-710	261	14	inhibitory	inhibitory	ADJ
biomedich-710	261	15	efficacy	efficacy	NOUN
biomedich-710	261	16	.	.	PUNCT
biomedich-710	262	1	conclusion	conclusion	NOUN
biomedich-710	262	2	selected	select	VERB
biomedich-710	262	3	phytochemicals	phytochemical	NOUN
biomedich-710	262	4	of	of	ADP
biomedich-710	262	5	coccinia	coccinia	NOUN
biomedich-710	262	6	grandis	grandis	PROPN
biomedich-710	262	7	leaves	leave	NOUN
biomedich-710	262	8	were	be	AUX
biomedich-710	262	9	evaluated	evaluate	VERB
biomedich-710	262	10	in	in	ADP
biomedich-710	262	11	silico	silico	NOUN
biomedich-710	262	12	to	to	PART
biomedich-710	262	13	determine	determine	VERB
biomedich-710	262	14	their	their	PRON
biomedich-710	262	15	antimicrobial	antimicrobial	ADJ
biomedich-710	262	16	activity	activity	NOUN
biomedich-710	262	17	against	against	ADP
biomedich-710	262	18	penicillin	penicillin	NOUN
biomedich-710	262	19	-	-	PUNCT
biomedich-710	262	20	binding	bind	VERB
biomedich-710	262	21	protein	protein	NOUN
biomedich-710	262	22	5	5	NUM
biomedich-710	262	23	(	(	PUNCT
biomedich-710	262	24	pbp	pbp	NOUN
biomedich-710	262	25	5	5	NUM
biomedich-710	262	26	)	)	PUNCT
biomedich-710	262	27	and	and	CCONJ
biomedich-710	262	28	topoisomerase	topoisomerase	NOUN
biomedich-710	262	29	iv	iv	NUM
biomedich-710	262	30	pare	pare	NOUN
biomedich-710	262	31	24kda	24kda	NOUN
biomedich-710	262	32	subunit	subunit	NOUN
biomedich-710	262	33	of	of	ADP
biomedich-710	262	34	escherichia	escherichia	NOUN
biomedich-710	262	35	coli	coli	NOUN
biomedich-710	262	36	and	and	CCONJ
biomedich-710	262	37	topoisomerase	topoisomerase	NOUN
biomedich-710	262	38	iv	iv	NUM
biomedich-710	262	39	pare	pare	NOUN
biomedich-710	262	40	24kda	24kda	NOUN
biomedich-710	262	41	subunit	subunit	NOUN
biomedich-710	262	42	of	of	ADP
biomedich-710	262	43	staphylococcus	staphylococcus	NOUN
biomedich-710	262	44	aureus	aureus	NOUN
biomedich-710	262	45	.	.	PUNCT
biomedich-710	263	1	physiochemical	physiochemical	ADJ
biomedich-710	263	2	and	and	CCONJ
biomedich-710	263	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	263	4	properties	property	NOUN
biomedich-710	263	5	of	of	ADP
biomedich-710	263	6	selected	select	VERB
biomedich-710	263	7	molecules	molecule	NOUN
biomedich-710	263	8	were	be	AUX
biomedich-710	263	9	also	also	ADV
biomedich-710	263	10	evaluated	evaluate	VERB
biomedich-710	263	11	.	.	PUNCT
biomedich-710	264	1	molecular	molecular	ADJ
biomedich-710	264	2	docking	docking	NOUN
biomedich-710	264	3	,	,	PUNCT
biomedich-710	264	4	physiochemical	physiochemical	ADJ
biomedich-710	264	5	and	and	CCONJ
biomedich-710	264	6	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	264	7	results	result	NOUN
biomedich-710	264	8	were	be	AUX
biomedich-710	264	9	compared	compare	VERB
biomedich-710	264	10	with	with	ADP
biomedich-710	264	11	reference	reference	NOUN
biomedich-710	264	12	molecules	molecule	NOUN
biomedich-710	264	13	which	which	PRON
biomedich-710	264	14	are	be	AUX
biomedich-710	264	15	penicillin	penicillin	NOUN
biomedich-710	264	16	and	and	CCONJ
biomedich-710	264	17	novobiocin	novobiocin	PROPN
biomedich-710	264	18	which	which	PRON
biomedich-710	264	19	are	be	AUX
biomedich-710	264	20	commercially	commercially	ADV
biomedich-710	264	21	available	available	ADJ
biomedich-710	264	22	antibiotics	antibiotic	NOUN
biomedich-710	264	23	.	.	PUNCT
biomedich-710	265	1	out	out	ADP
biomedich-710	265	2	of	of	ADP
biomedich-710	265	3	the	the	DET
biomedich-710	265	4	tested	test	VERB
biomedich-710	265	5	molecules	molecule	NOUN
biomedich-710	265	6	,	,	PUNCT
biomedich-710	265	7	lupeol	lupeol	NOUN
biomedich-710	265	8	and	and	CCONJ
biomedich-710	265	9	betasitosterol	betasitosterol	NOUN
biomedich-710	265	10	exhibited	exhibit	VERB
biomedich-710	265	11	better	well	ADJ
biomedich-710	265	12	inhibition	inhibition	NOUN
biomedich-710	265	13	capabilities	capability	NOUN
biomedich-710	265	14	against	against	ADP
biomedich-710	265	15	pbp5	pbp5	NOUN
biomedich-710	265	16	of	of	ADP
biomedich-710	265	17	escherichia	escherichia	NOUN
biomedich-710	265	18	coli	coli	NOUN
biomedich-710	265	19	than	than	ADP
biomedich-710	265	20	penicillin	penicillin	PROPN
biomedich-710	265	21	.	.	PUNCT
biomedich-710	266	1	quercetin	quercetin	NOUN
biomedich-710	266	2	,	,	PUNCT
biomedich-710	266	3	kaempferol	kaempferol	NOUN
biomedich-710	266	4	,	,	PUNCT
biomedich-710	266	5	naringenin	naringenin	PROPN
biomedich-710	266	6	,	,	PUNCT
biomedich-710	266	7	isoquercetin	isoquercetin	NOUN
biomedich-710	266	8	,	,	PUNCT
biomedich-710	266	9	lupeol	lupeol	NOUN
biomedich-710	266	10	,	,	PUNCT
biomedich-710	266	11	betasitosterol	betasitosterol	NOUN
biomedich-710	266	12	and	and	CCONJ
biomedich-710	266	13	sanguinarine	sanguinarine	NOUN
biomedich-710	266	14	exhibit	exhibit	VERB
biomedich-710	266	15	higher	high	ADJ
biomedich-710	266	16	binding	bind	VERB
biomedich-710	266	17	affinity	affinity	NOUN
biomedich-710	266	18	to	to	PART
biomedich-710	266	19	topoisomerase	topoisomerase	VERB
biomedich-710	266	20	iv	iv	NUM
biomedich-710	266	21	pare	pare	NOUN
biomedich-710	266	22	24kda	24kda	NOUN
biomedich-710	266	23	subunit	subunit	NOUN
biomedich-710	266	24	of	of	ADP
biomedich-710	266	25	both	both	DET
biomedich-710	266	26	escherichia	escherichia	NOUN
biomedich-710	266	27	coli	coli	NOUN
biomedich-710	266	28	and	and	CCONJ
biomedich-710	266	29	staphylococcus	staphylococcus	NOUN
biomedich-710	266	30	aureus	aureus	NOUN
biomedich-710	266	31	than	than	ADP
biomedich-710	266	32	novobiocin	novobiocin	VERB
biomedich-710	266	33	.	.	PUNCT
biomedich-710	267	1	selected	select	VERB
biomedich-710	267	2	natural	natural	ADJ
biomedich-710	267	3	molecules	molecule	NOUN
biomedich-710	267	4	exhibit	exhibit	VERB
biomedich-710	267	5	higher	high	ADJ
biomedich-710	267	6	binding	bind	VERB
biomedich-710	267	7	affinity	affinity	NOUN
biomedich-710	267	8	towards	towards	ADP
biomedich-710	267	9	topoisomerase	topoisomerase	NOUN
biomedich-710	267	10	iv	iv	NUM
biomedich-710	267	11	pare	pare	NOUN
biomedich-710	267	12	24kda	24kda	NOUN
biomedich-710	267	13	subunit	subunit	NOUN
biomedich-710	267	14	than	than	ADP
biomedich-710	267	15	pbp5	pbp5	PROPN
biomedich-710	267	16	of	of	ADP
biomedich-710	267	17	e.	e.	PROPN
biomedich-710	267	18	coli	coli	PROPN
biomedich-710	267	19	.	.	PUNCT
biomedich-710	268	1	results	result	NOUN
biomedich-710	268	2	in	in	ADP
biomedich-710	268	3	this	this	DET
biomedich-710	268	4	study	study	NOUN
biomedich-710	268	5	suggest	suggest	VERB
biomedich-710	268	6	that	that	SCONJ
biomedich-710	268	7	these	these	DET
biomedich-710	268	8	selected	select	VERB
biomedich-710	268	9	phytochemicals	phytochemical	NOUN
biomedich-710	268	10	of	of	ADP
biomedich-710	268	11	coccinia	coccinia	NOUN
biomedich-710	268	12	grandis	grandi	NOUN
biomedich-710	268	13	leaves	leave	VERB
biomedich-710	268	14	may	may	AUX
biomedich-710	268	15	serve	serve	VERB
biomedich-710	268	16	as	as	ADP
biomedich-710	268	17	promising	promise	VERB
biomedich-710	268	18	candidates	candidate	NOUN
biomedich-710	268	19	for	for	ADP
biomedich-710	268	20	development	development	NOUN
biomedich-710	268	21	of	of	ADP
biomedich-710	268	22	antimicrobial	antimicrobial	ADJ
biomedich-710	268	23	agents	agent	NOUN
biomedich-710	268	24	against	against	ADP
biomedich-710	268	25	resistant	resistant	ADJ
biomedich-710	268	26	strains	strain	NOUN
biomedich-710	268	27	of	of	ADP
biomedich-710	268	28	escherichia	escherichia	NOUN
biomedich-710	268	29	coli	coli	NOUN
biomedich-710	268	30	and	and	CCONJ
biomedich-710	268	31	staphylococcus	staphylococcus	NOUN
biomedich-710	268	32	aureus	aureus	NOUN
biomedich-710	268	33	.	.	PUNCT
biomedich-710	269	1	further	further	ADJ
biomedich-710	269	2	studies	study	NOUN
biomedich-710	269	3	should	should	AUX
biomedich-710	269	4	focus	focus	VERB
biomedich-710	269	5	on	on	ADP
biomedich-710	269	6	optimizing	optimize	VERB
biomedich-710	269	7	the	the	DET
biomedich-710	269	8	structure	structure	NOUN
biomedich-710	269	9	of	of	ADP
biomedich-710	269	10	these	these	DET
biomedich-710	269	11	selected	select	VERB
biomedich-710	269	12	molecules	molecule	NOUN
biomedich-710	269	13	to	to	PART
biomedich-710	269	14	enhance	enhance	VERB
biomedich-710	269	15	their	their	PRON
biomedich-710	269	16	binding	bind	VERB
biomedich-710	269	17	affinity	affinity	NOUN
biomedich-710	269	18	and	and	CCONJ
biomedich-710	269	19	the	the	DET
biomedich-710	269	20	inhibitory	inhibitory	ADJ
biomedich-710	269	21	potency	potency	NOUN
biomedich-710	269	22	.	.	PUNCT
biomedich-710	270	1	acknowledgements	acknowledgement	NOUN
biomedich-710	270	2	:	:	PUNCT
biomedich-710	271	1	i	i	PRON
biomedich-710	271	2	would	would	AUX
biomedich-710	271	3	like	like	VERB
biomedich-710	271	4	to	to	PART
biomedich-710	271	5	express	express	VERB
biomedich-710	271	6	my	my	PRON
biomedich-710	271	7	sincere	sincere	ADJ
biomedich-710	271	8	gratitude	gratitude	NOUN
biomedich-710	271	9	to	to	ADP
biomedich-710	271	10	dr	dr	PROPN
biomedich-710	272	1	.	.	PROPN
biomedich-710	272	2	m.g.a.n	m.g.a.n	PROPN
biomedich-710	272	3	.	.	PROPN
biomedich-710	272	4	perera	perera	PROPN
biomedich-710	272	5	from	from	ADP
biomedich-710	272	6	the	the	DET
biomedich-710	272	7	faculty	faculty	NOUN
biomedich-710	272	8	of	of	ADP
biomedich-710	272	9	applied	apply	VERB
biomedich-710	272	10	science	science	NOUN
biomedich-710	272	11	at	at	ADP
biomedich-710	272	12	the	the	DET
biomedich-710	272	13	university	university	NOUN
biomedich-710	272	14	of	of	ADP
biomedich-710	272	15	sabaragamuwa	sabaragamuwa	NOUN
biomedich-710	272	16	for	for	ADP
biomedich-710	272	17	his	his	PRON
biomedich-710	272	18	invaluable	invaluable	ADJ
biomedich-710	272	19	guidance	guidance	NOUN
biomedich-710	272	20	and	and	CCONJ
biomedich-710	272	21	support	support	NOUN
biomedich-710	272	22	throughout	throughout	ADP
biomedich-710	272	23	this	this	DET
biomedich-710	272	24	research	research	NOUN
biomedich-710	272	25	.	.	PUNCT
biomedich-710	273	1	authors	author	NOUN
biomedich-710	273	2	’	'	PUNCT
biomedich-710	273	3	contributions	contribution	NOUN
biomedich-710	273	4	:	:	PUNCT
biomedich-710	273	5	m.	m.	NOUN
biomedich-710	273	6	isuranga	isuranga	PROPN
biomedich-710	273	7	designed	design	VERB
biomedich-710	273	8	the	the	DET
biomedich-710	273	9	study	study	NOUN
biomedich-710	273	10	.	.	PUNCT
biomedich-710	274	1	computational	computational	ADJ
biomedich-710	274	2	analysis	analysis	NOUN
biomedich-710	274	3	and	and	CCONJ
biomedich-710	274	4	data	datum	NOUN
biomedich-710	274	5	interpretation	interpretation	NOUN
biomedich-710	274	6	were	be	AUX
biomedich-710	274	7	conducted	conduct	VERB
biomedich-710	274	8	by	by	ADP
biomedich-710	274	9	m.	m.	NOUN
biomedich-710	274	10	isuranga	isuranga	NOUN
biomedich-710	274	11	and	and	CCONJ
biomedich-710	274	12	d.n	d.n	PROPN
biomedich-710	274	13	.	.	PROPN
biomedich-710	274	14	danthanarayana	danthanarayana	PROPN
biomedich-710	274	15	.	.	PUNCT
biomedich-710	275	1	the	the	DET
biomedich-710	275	2	manuscript	manuscript	NOUN
biomedich-710	275	3	was	be	AUX
biomedich-710	275	4	written	write	VERB
biomedich-710	275	5	by	by	ADP
biomedich-710	275	6	both	both	DET
biomedich-710	275	7	m.	m.	NOUN
biomedich-710	275	8	isuranga	isuranga	NOUN
biomedich-710	275	9	and	and	CCONJ
biomedich-710	275	10	d.n	d.n	PROPN
biomedich-710	275	11	.	.	PROPN
biomedich-710	275	12	danthanarayana	danthanarayana	PROPN
biomedich-710	275	13	.	.	PUNCT
biomedich-710	276	1	competing	compete	VERB
biomedich-710	276	2	interests	interest	NOUN
biomedich-710	276	3	:	:	PUNCT
biomedich-710	276	4	the	the	DET
biomedich-710	276	5	author	author	NOUN
biomedich-710	276	6	declares	declare	VERB
biomedich-710	276	7	that	that	SCONJ
biomedich-710	276	8	there	there	PRON
biomedich-710	276	9	are	be	VERB
biomedich-710	276	10	no	no	DET
biomedich-710	276	11	competing	compete	VERB
biomedich-710	276	12	interests	interest	NOUN
biomedich-710	276	13	.	.	PUNCT
biomedich-710	277	1	references	reference	NOUN
biomedich-710	277	2	bellon	bellon	NOUN
biomedich-710	277	3	,	,	PUNCT
biomedich-710	277	4	s.	s.	PROPN
biomedich-710	277	5	,	,	PUNCT
biomedich-710	277	6	parsons	parson	NOUN
biomedich-710	277	7	,	,	PUNCT
biomedich-710	277	8	j.	j.	PROPN
biomedich-710	277	9	d.	d.	PROPN
biomedich-710	277	10	,	,	PUNCT
biomedich-710	277	11	wei	wei	PROPN
biomedich-710	277	12	,	,	PUNCT
biomedich-710	277	13	y.	y.	PROPN
biomedich-710	277	14	,	,	PUNCT
biomedich-710	277	15	hayakawa	hayakawa	PROPN
biomedich-710	277	16	,	,	PUNCT
biomedich-710	277	17	k.	k.	PROPN
biomedich-710	277	18	,	,	PUNCT
biomedich-710	277	19	swenson	swenson	PROPN
biomedich-710	277	20	,	,	PUNCT
biomedich-710	277	21	l.	l.	PROPN
biomedich-710	277	22	l.	l.	PROPN
biomedich-710	277	23	,	,	PUNCT
biomedich-710	277	24	charifson	charifson	PROPN
biomedich-710	277	25	,	,	PUNCT
biomedich-710	277	26	p.	p.	PROPN
biomedich-710	277	27	s.	s.	PROPN
biomedich-710	277	28	,	,	PUNCT
biomedich-710	277	29	lippke	lippke	PROPN
biomedich-710	277	30	,	,	PUNCT
biomedich-710	277	31	j.	j.	PROPN
biomedich-710	277	32	a.	a.	PROPN
biomedich-710	277	33	,	,	PUNCT
biomedich-710	277	34	aldape	aldape	PROPN
biomedich-710	277	35	,	,	PUNCT
biomedich-710	277	36	r.	r.	PROPN
biomedich-710	277	37	,	,	PUNCT
biomedich-710	277	38	&	&	CCONJ
biomedich-710	277	39	gross	gross	PROPN
biomedich-710	277	40	,	,	PUNCT
biomedich-710	277	41	c.	c.	PROPN
biomedich-710	277	42	h.	h.	PROPN
biomedich-710	277	43	(	(	PUNCT
biomedich-710	277	44	2004	2004	NUM
biomedich-710	277	45	)	)	PUNCT
biomedich-710	277	46	.	.	PUNCT
biomedich-710	278	1	crystal	crystal	NOUN
biomedich-710	278	2	structures	structure	NOUN
biomedich-710	278	3	of	of	ADP
biomedich-710	278	4	escherichia	escherichia	NOUN
biomedich-710	278	5	coli	coli	NOUN
biomedich-710	278	6	topoisomerase	topoisomerase	NOUN
biomedich-710	278	7	iv	iv	NUM
biomedich-710	278	8	pare	pare	NOUN
biomedich-710	278	9	subunit	subunit	NOUN
biomedich-710	278	10	(	(	PUNCT
biomedich-710	278	11	24	24	NUM
biomedich-710	278	12	and	and	CCONJ
biomedich-710	278	13	43	43	NUM
biomedich-710	278	14	kilodaltons	kilodalton	NOUN
biomedich-710	278	15	):	):	PUNCT
biomedich-710	278	16	a	a	DET
biomedich-710	278	17	single	single	ADJ
biomedich-710	278	18	residue	residue	NOUN
biomedich-710	278	19	dictates	dictate	VERB
biomedich-710	278	20	differences	difference	NOUN
biomedich-710	278	21	in	in	ADP
biomedich-710	278	22	novobiocin	novobiocin	ADJ
biomedich-710	278	23	potency	potency	NOUN
biomedich-710	278	24	against	against	ADP
biomedich-710	278	25	topoisomerase	topoisomerase	NOUN
biomedich-710	278	26	iv	iv	NUM
biomedich-710	278	27	and	and	CCONJ
biomedich-710	278	28	dna	dna	PROPN
biomedich-710	278	29	gyrase	gyrase	NOUN
biomedich-710	278	30	.	.	PUNCT
biomedich-710	279	1	antimicrobial	antimicrobial	ADJ
biomedich-710	279	2	agents	agent	NOUN
biomedich-710	279	3	and	and	CCONJ
biomedich-710	279	4	chemotherapy	chemotherapy	NOUN
biomedich-710	279	5	,	,	PUNCT
biomedich-710	279	6	48(5	48(5	NUM
biomedich-710	279	7	)	)	PUNCT
biomedich-710	279	8	,	,	PUNCT
biomedich-710	279	9	1856–1864	1856–1864	NUM
biomedich-710	279	10	.	.	PUNCT
biomedich-710	280	1	https://doi.org/10.1128/aac.48.5.1856-1864.2004	https://doi.org/10.1128/aac.48.5.1856-1864.2004	PROPN
biomedich-710	280	2	farrukh	farrukh	PROPN
biomedich-710	280	3	,	,	PUNCT
biomedich-710	280	4	u.	u.	PROPN
biomedich-710	280	5	,	,	PUNCT
biomedich-710	280	6	shareef	shareef	PROPN
biomedich-710	280	7	,	,	PUNCT
biomedich-710	280	8	h.	h.	PROPN
biomedich-710	280	9	,	,	PUNCT
biomedich-710	280	10	&	&	CCONJ
biomedich-710	280	11	ayub	ayub	PROPN
biomedich-710	280	12	ali	ali	PROPN
biomedich-710	280	13	,	,	PUNCT
biomedich-710	280	14	syed	syed	ADJ
biomedich-710	280	15	.	.	PUNCT
biomedich-710	281	1	(	(	PUNCT
biomedich-710	281	2	2008	2008	NUM
biomedich-710	281	3	)	)	PUNCT
biomedich-710	281	4	.	.	PUNCT
biomedich-710	282	1	antibacterial	antibacterial	ADJ
biomedich-710	282	2	activities	activity	NOUN
biomedich-710	282	3	of	of	ADP
biomedich-710	282	4	coccinia	coccinia	NOUN
biomedich-710	282	5	grandis	grandis	PROPN
biomedich-710	282	6	l.	l.	PROPN
biomedich-710	282	7	https://www.researchgate.net/publication/230795441	https://www.researchgate.net/publication/230795441	PROPN
biomedich-710	282	8	global	global	ADJ
biomedich-710	282	9	antimicrobial	antimicrobial	ADJ
biomedich-710	282	10	resistance	resistance	NOUN
biomedich-710	282	11	and	and	CCONJ
biomedich-710	282	12	use	use	VERB
biomedich-710	282	13	surveillance	surveillance	NOUN
biomedich-710	282	14	system	system	NOUN
biomedich-710	282	15	(	(	PUNCT
biomedich-710	282	16	glass	glass	NOUN
biomedich-710	282	17	)	)	PUNCT
biomedich-710	282	18	report	report	NOUN
biomedich-710	282	19	2022	2022	NUM
biomedich-710	282	20	.	.	PUNCT
biomedich-710	283	1	(	(	PUNCT
biomedich-710	283	2	2022	2022	NUM
biomedich-710	283	3	)	)	PUNCT
biomedich-710	283	4	.	.	PUNCT
biomedich-710	284	1	world	world	PROPN
biomedich-710	284	2	health	health	PROPN
biomedich-710	284	3	organization	organization	PROPN
biomedich-710	284	4	.	.	PUNCT
biomedich-710	285	1	kumar	kumar	PROPN
biomedich-710	285	2	,	,	PUNCT
biomedich-710	285	3	k.	k.	PROPN
biomedich-710	285	4	,	,	PUNCT
biomedich-710	285	5	kumar	kumar	PROPN
biomedich-710	285	6	,	,	PUNCT
biomedich-710	285	7	s.	s.	PROPN
biomedich-710	285	8	r.	r.	PROPN
biomedich-710	285	9	,	,	PUNCT
biomedich-710	285	10	dwivedi	dwivedi	PROPN
biomedich-710	285	11	,	,	PUNCT
biomedich-710	285	12	v.	v.	PROPN
biomedich-710	285	13	,	,	PUNCT
biomedich-710	285	14	rai	rai	PROPN
biomedich-710	285	15	,	,	PUNCT
biomedich-710	285	16	a.	a.	NOUN
biomedich-710	285	17	,	,	PUNCT
biomedich-710	285	18	shukla	shukla	NOUN
biomedich-710	285	19	,	,	PUNCT
biomedich-710	285	20	a.	a.	PROPN
biomedich-710	285	21	k.	k.	PROPN
biomedich-710	285	22	,	,	PUNCT
biomedich-710	285	23	shanker	shanker	PROPN
biomedich-710	285	24	,	,	PUNCT
biomedich-710	285	25	k.	k.	PROPN
biomedich-710	285	26	,	,	PUNCT
biomedich-710	285	27	&	&	CCONJ
biomedich-710	285	28	nagegowda	nagegowda	PROPN
biomedich-710	285	29	,	,	PUNCT
biomedich-710	285	30	d.	d.	PROPN
biomedich-710	285	31	a.	a.	PROPN
biomedich-710	285	32	(	(	PUNCT
biomedich-710	285	33	2015	2015	NUM
biomedich-710	285	34	)	)	PUNCT
biomedich-710	285	35	.	.	PUNCT
biomedich-710	286	1	precursor	precursor	NOUN
biomedich-710	286	2	feeding	feeding	NOUN
biomedich-710	286	3	studies	study	NOUN
biomedich-710	286	4	and	and	CCONJ
biomedich-710	286	5	molecular	molecular	ADJ
biomedich-710	286	6	characterization	characterization	NOUN
biomedich-710	286	7	of	of	ADP
biomedich-710	286	8	geraniol	geraniol	NOUN
biomedich-710	286	9	synthase	synthase	NOUN
biomedich-710	286	10	establish	establish	VERB
biomedich-710	286	11	the	the	DET
biomedich-710	286	12	limiting	limit	VERB
biomedich-710	286	13	role	role	NOUN
biomedich-710	286	14	of	of	ADP
biomedich-710	286	15	geraniol	geraniol	NOUN
biomedich-710	286	16	in	in	ADP
biomedich-710	286	17	monoterpene	monoterpene	ADJ
biomedich-710	286	18	indole	indole	NOUN
biomedich-710	286	19	alkaloid	alkaloid	NOUN
biomedich-710	286	20	biosynthesis	biosynthesis	NOUN
biomedich-710	286	21	in	in	ADP
biomedich-710	286	22	catharanthus	catharanthus	NOUN
biomedich-710	286	23	roseus	roseus	NOUN
biomedich-710	286	24	leaves	leave	VERB
biomedich-710	286	25	.	.	PUNCT
biomedich-710	287	1	plant	plant	NOUN
biomedich-710	287	2	science	science	NOUN
biomedich-710	287	3	,	,	PUNCT
biomedich-710	287	4	239	239	NUM
biomedich-710	287	5	,	,	PUNCT
biomedich-710	287	6	56–66	56–66	NUM
biomedich-710	287	7	.	.	PUNCT
biomedich-710	288	1	https://doi.org/10.1016/j.plantsci.2015.07.007	https://doi.org/10.1016/j.plantsci.2015.07.007	PROPN
biomedich-710	288	2	larsson	larsson	PROPN
biomedich-710	288	3	,	,	PUNCT
biomedich-710	288	4	d.	d.	PROPN
biomedich-710	288	5	g.	g.	PROPN
biomedich-710	288	6	j.	j.	PROPN
biomedich-710	288	7	,	,	PUNCT
biomedich-710	288	8	&	&	CCONJ
biomedich-710	288	9	flach	flach	PROPN
biomedich-710	288	10	,	,	PUNCT
biomedich-710	288	11	c.	c.	PROPN
biomedich-710	288	12	f.	f.	PROPN
biomedich-710	288	13	(	(	PUNCT
biomedich-710	288	14	2022	2022	NUM
biomedich-710	288	15	)	)	PUNCT
biomedich-710	288	16	.	.	PUNCT
biomedich-710	289	1	antibiotic	antibiotic	ADJ
biomedich-710	289	2	resistance	resistance	NOUN
biomedich-710	289	3	in	in	ADP
biomedich-710	289	4	the	the	DET
biomedich-710	289	5	environment	environment	NOUN
biomedich-710	289	6	.	.	PUNCT
biomedich-710	290	1	in	in	ADP
biomedich-710	290	2	nature	nature	NOUN
biomedich-710	290	3	reviews	review	VERB
biomedich-710	290	4	microbiology	microbiology	NOUN
biomedich-710	290	5	(	(	PUNCT
biomedich-710	290	6	vol	vol	NOUN
biomedich-710	290	7	.	.	PROPN
biomedich-710	290	8	20	20	NUM
biomedich-710	290	9	,	,	PUNCT
biomedich-710	290	10	issue	issue	NOUN
biomedich-710	290	11	5	5	NUM
biomedich-710	290	12	,	,	PUNCT
biomedich-710	290	13	pp	pp	ADJ
biomedich-710	290	14	.	.	PUNCT
biomedich-710	291	1	257–269	257–269	NUM
biomedich-710	291	2	)	)	PUNCT
biomedich-710	291	3	.	.	PUNCT
biomedich-710	292	1	nature	nature	NOUN
biomedich-710	292	2	research	research	NOUN
biomedich-710	292	3	.	.	PUNCT
biomedich-710	293	1	https://doi.org/10.1038/s41579-021-00649-x	https://doi.org/10.1038/s41579-021-00649-x	NOUN
biomedich-710	293	2	lawan	lawan	PROPN
biomedich-710	293	3	,	,	PUNCT
biomedich-710	293	4	h.	h.	PROPN
biomedich-710	293	5	,	,	PUNCT
biomedich-710	293	6	&	&	CCONJ
biomedich-710	293	7	tharakee	tharakee	PROPN
biomedich-710	293	8	,	,	PUNCT
biomedich-710	293	9	h.	h.	PROPN
biomedich-710	293	10	(	(	PUNCT
biomedich-710	293	11	2023	2023	NUM
biomedich-710	293	12	)	)	PUNCT
biomedich-710	293	13	.	.	PUNCT
biomedich-710	294	1	in	in	ADP
biomedich-710	294	2	silico	silico	NOUN
biomedich-710	294	3	study	study	NOUN
biomedich-710	294	4	on	on	ADP
biomedich-710	294	5	structural	structural	ADJ
biomedich-710	294	6	inhibition	inhibition	NOUN
biomedich-710	294	7	of	of	ADP
biomedich-710	294	8	bacterial	bacterial	ADJ
biomedich-710	294	9	dna	dna	NOUN
biomedich-710	294	10	gyrase	gyrase	NOUN
biomedich-710	294	11	by	by	ADP
biomedich-710	294	12	major	major	ADJ
biomedich-710	294	13	secondary	secondary	ADJ
biomedich-710	294	14	metabolites	metabolite	NOUN
biomedich-710	294	15	found	find	VERB
biomedich-710	294	16	in	in	ADP
biomedich-710	294	17	grape	grape	NOUN
biomedich-710	294	18	seed	seed	NOUN
biomedich-710	294	19	extract	extract	NOUN
biomedich-710	294	20	.	.	PUNCT
biomedich-710	295	1	biology	biology	NOUN
biomedich-710	295	2	,	,	PUNCT
biomedich-710	295	3	medicine	medicine	NOUN
biomedich-710	295	4	,	,	PUNCT
biomedich-710	295	5	&	&	CCONJ
biomedich-710	295	6	natural	natural	ADJ
biomedich-710	295	7	product	product	NOUN
biomedich-710	295	8	chemistry	chemistry	NOUN
biomedich-710	295	9	,	,	PUNCT
biomedich-710	295	10	12(2	12(2	NUM
biomedich-710	295	11	)	)	PUNCT
biomedich-710	295	12	,	,	PUNCT
biomedich-710	295	13	585–592	585–592	NUM
biomedich-710	295	14	.	.	PUNCT
biomedich-710	296	1	https://doi.org/10.14421/biomedich.2023.122.585-592	https://doi.org/10.14421/biomedich.2023.122.585-592	X
biomedich-710	296	2	lipinski	lipinski	PROPN
biomedich-710	296	3	,	,	PUNCT
biomedich-710	296	4	c.	c.	PROPN
biomedich-710	296	5	a.	a.	PROPN
biomedich-710	296	6	,	,	PUNCT
biomedich-710	296	7	lombardo	lombardo	PROPN
biomedich-710	296	8	,	,	PUNCT
biomedich-710	296	9	f.	f.	PROPN
biomedich-710	296	10	,	,	PUNCT
biomedich-710	296	11	dominy	dominy	PROPN
biomedich-710	296	12	,	,	PUNCT
biomedich-710	296	13	b.	b.	PROPN
biomedich-710	296	14	w.	w.	PROPN
biomedich-710	296	15	,	,	PUNCT
biomedich-710	296	16	&	&	CCONJ
biomedich-710	296	17	feeney	feeney	PROPN
biomedich-710	296	18	,	,	PUNCT
biomedich-710	296	19	p.	p.	PROPN
biomedich-710	296	20	j.	j.	PROPN
biomedich-710	296	21	(	(	PUNCT
biomedich-710	296	22	2001	2001	NUM
biomedich-710	296	23	)	)	PUNCT
biomedich-710	296	24	.	.	PUNCT
biomedich-710	297	1	experimental	experimental	ADJ
biomedich-710	297	2	and	and	CCONJ
biomedich-710	297	3	computational	computational	ADJ
biomedich-710	297	4	approaches	approach	NOUN
biomedich-710	297	5	to	to	PART
biomedich-710	297	6	estimate	estimate	VERB
biomedich-710	297	7	solubility	solubility	NOUN
biomedich-710	297	8	and	and	CCONJ
biomedich-710	297	9	permeability	permeability	NOUN
biomedich-710	297	10	in	in	ADP
biomedich-710	297	11	drug	drug	NOUN
biomedich-710	297	12	discovery	discovery	NOUN
biomedich-710	297	13	and	and	CCONJ
biomedich-710	297	14	development	development	NOUN
biomedich-710	297	15	q	q	PROPN
biomedich-710	297	16	settings	setting	NOUN
biomedich-710	297	17	.	.	PUNCT
biomedich-710	298	1	in	in	ADP
biomedich-710	298	2	advanced	advanced	ADJ
biomedich-710	298	3	drug	drug	NOUN
biomedich-710	298	4	delivery	delivery	NOUN
biomedich-710	298	5	reviews	review	NOUN
biomedich-710	298	6	(	(	PUNCT
biomedich-710	298	7	vol	vol	NOUN
biomedich-710	298	8	.	.	PROPN
biomedich-710	298	9	46	46	NUM
biomedich-710	298	10	)	)	PUNCT
biomedich-710	298	11	.	.	PUNCT
biomedich-710	299	1	www.elsevier.com/locate/drugdeliv	www.elsevier.com/locate/drugdeliv	PROPN
biomedich-710	299	2	lu	lu	PROPN
biomedich-710	299	3	,	,	PUNCT
biomedich-710	299	4	j.	j.	PROPN
biomedich-710	299	5	,	,	PUNCT
biomedich-710	299	6	patel	patel	PROPN
biomedich-710	299	7	,	,	PUNCT
biomedich-710	299	8	s.	s.	PROPN
biomedich-710	299	9	,	,	PUNCT
biomedich-710	299	10	sharma	sharma	PROPN
biomedich-710	299	11	,	,	PUNCT
biomedich-710	299	12	n.	n.	NOUN
biomedich-710	299	13	,	,	PUNCT
biomedich-710	299	14	soisson	soisson	PROPN
biomedich-710	299	15	,	,	PUNCT
biomedich-710	299	16	s.	s.	PROPN
biomedich-710	299	17	m.	m.	PROPN
biomedich-710	299	18	,	,	PUNCT
biomedich-710	299	19	kishii	kishii	PROPN
biomedich-710	299	20	,	,	PUNCT
biomedich-710	299	21	r.	r.	PROPN
biomedich-710	299	22	,	,	PUNCT
biomedich-710	299	23	takei	takei	PROPN
biomedich-710	299	24	,	,	PUNCT
biomedich-710	299	25	m.	m.	NOUN
biomedich-710	299	26	,	,	PUNCT
biomedich-710	299	27	fukuda	fukuda	PROPN
biomedich-710	299	28	,	,	PUNCT
biomedich-710	299	29	y.	y.	PROPN
biomedich-710	299	30	,	,	PUNCT
biomedich-710	299	31	lumb	lumb	PROPN
biomedich-710	299	32	,	,	PUNCT
biomedich-710	299	33	k.	k.	PROPN
biomedich-710	299	34	j.	j.	PROPN
biomedich-710	299	35	,	,	PUNCT
biomedich-710	299	36	&	&	CCONJ
biomedich-710	299	37	singh	singh	PROPN
biomedich-710	299	38	,	,	PUNCT
biomedich-710	299	39	s.	s.	PROPN
biomedich-710	299	40	b.	b.	PROPN
biomedich-710	299	41	(	(	PUNCT
biomedich-710	299	42	2014b	2014b	NUM
biomedich-710	299	43	)	)	PUNCT
biomedich-710	299	44	.	.	PUNCT
biomedich-710	300	1	structures	structure	NOUN
biomedich-710	300	2	of	of	ADP
biomedich-710	300	3	kibdelomycin	kibdelomycin	PROPN
biomedich-710	300	4	bound	bind	VERB
biomedich-710	300	5	to	to	PART
biomedich-710	300	6	staphylococcus	staphylococcus	NOUN
biomedich-710	300	7	aureus	aureus	NOUN
biomedich-710	300	8	gyrb	gyrb	PROPN
biomedich-710	300	9	and	and	CCONJ
biomedich-710	300	10	pare	pare	PROPN
biomedich-710	300	11	showed	show	VERB
biomedich-710	300	12	a	a	DET
biomedich-710	300	13	novel	novel	ADJ
biomedich-710	300	14	u	u	NOUN
biomedich-710	300	15	-	-	ADJ
biomedich-710	300	16	shaped	shaped	ADJ
biomedich-710	300	17	binding	binding	ADJ
biomedich-710	300	18	mode	mode	NOUN
biomedich-710	300	19	.	.	PUNCT
biomedich-710	301	1	acs	acs	PROPN
biomedich-710	301	2	chemical	chemical	PROPN
biomedich-710	301	3	biology	biology	NOUN
biomedich-710	301	4	,	,	PUNCT
biomedich-710	301	5	9(9	9(9	NUM
biomedich-710	301	6	)	)	PUNCT
biomedich-710	301	7	,	,	PUNCT
biomedich-710	301	8	2023–2031	2023–2031	NUM
biomedich-710	301	9	.	.	PUNCT
biomedich-710	302	1	https://doi.org/10.1021/cb5001197	https://doi.org/10.1021/cb5001197	PROPN
biomedich-710	302	2	nicholas	nicholas	PROPN
biomedich-710	302	3	,	,	PUNCT
biomedich-710	302	4	r.	r.	PROPN
biomedich-710	302	5	a.	a.	PROPN
biomedich-710	302	6	,	,	PUNCT
biomedich-710	302	7	krings	krings	PROPN
biomedich-710	302	8	,	,	PUNCT
biomedich-710	302	9	s.	s.	PROPN
biomedich-710	302	10	,	,	PUNCT
biomedich-710	302	11	tomberg	tomberg	PROPN
biomedich-710	302	12	,	,	PUNCT
biomedich-710	302	13	j.	j.	PROPN
biomedich-710	302	14	,	,	PUNCT
biomedich-710	302	15	nicola	nicola	PROPN
biomedich-710	302	16	,	,	PUNCT
biomedich-710	302	17	g.	g.	PROPN
biomedich-710	302	18	,	,	PUNCT
biomedich-710	302	19	&	&	CCONJ
biomedich-710	302	20	davies	davy	NOUN
biomedich-710	302	21	,	,	PUNCT
biomedich-710	302	22	c.	c.	PROPN
biomedich-710	302	23	(	(	PUNCT
biomedich-710	302	24	2003	2003	NUM
biomedich-710	302	25	)	)	PUNCT
biomedich-710	302	26	.	.	PUNCT
biomedich-710	303	1	crystal	crystal	NOUN
biomedich-710	303	2	structure	structure	NOUN
biomedich-710	303	3	of	of	ADP
biomedich-710	303	4	wild	wild	ADJ
biomedich-710	303	5	-	-	PUNCT
biomedich-710	303	6	type	type	NOUN
biomedich-710	303	7	penicillin	penicillin	NOUN
biomedich-710	303	8	-	-	PUNCT
biomedich-710	303	9	binding	bind	VERB
biomedich-710	303	10	protein	protein	NOUN
biomedich-710	303	11	5	5	NUM
biomedich-710	303	12	from	from	ADP
biomedich-710	303	13	escherichia	escherichia	NOUN
biomedich-710	303	14	coli	coli	NOUN
biomedich-710	303	15	:	:	PUNCT
biomedich-710	303	16	implications	implication	NOUN
biomedich-710	303	17	for	for	ADP
biomedich-710	303	18	deacylation	deacylation	NOUN
biomedich-710	303	19	of	of	ADP
biomedich-710	303	20	the	the	DET
biomedich-710	303	21	acyl	acyl	ADJ
biomedich-710	303	22	-	-	PUNCT
biomedich-710	303	23	enzyme	enzyme	NOUN
biomedich-710	303	24	complex	complex	NOUN
biomedich-710	303	25	.	.	PUNCT
biomedich-710	304	1	journal	journal	NOUN
biomedich-710	304	2	of	of	ADP
biomedich-710	304	3	biological	biological	ADJ
biomedich-710	304	4	chemistry	chemistry	NOUN
biomedich-710	304	5	,	,	PUNCT
biomedich-710	304	6	552	552	NUM
biomedich-710	304	7	biology	biology	NOUN
biomedich-710	304	8	,	,	PUNCT
biomedich-710	304	9	medicine	medicine	NOUN
biomedich-710	304	10	,	,	PUNCT
biomedich-710	304	11	&	&	CCONJ
biomedich-710	304	12	natural	natural	ADJ
biomedich-710	304	13	product	product	NOUN
biomedich-710	304	14	chemistry	chemistry	NOUN
biomedich-710	304	15	14	14	NUM
biomedich-710	304	16	(	(	PUNCT
biomedich-710	304	17	1	1	NUM
biomedich-710	304	18	)	)	PUNCT
biomedich-710	304	19	,	,	PUNCT
biomedich-710	304	20	2025	2025	NUM
biomedich-710	304	21	:	:	PUNCT
biomedich-710	304	22	541	541	NUM
biomedich-710	304	23	-	-	SYM
biomedich-710	304	24	552	552	NUM
biomedich-710	304	25	278(52	278(52	NUM
biomedich-710	304	26	)	)	PUNCT
biomedich-710	304	27	,	,	PUNCT
biomedich-710	304	28	52826–52833	52826–52833	NUM
biomedich-710	304	29	.	.	PUNCT
biomedich-710	305	1	https://doi.org/10.1074/jbc.m310177200	https://doi.org/10.1074/jbc.m310177200	PROPN
biomedich-710	305	2	ramachandran	ramachandran	PROPN
biomedich-710	305	3	,	,	PUNCT
biomedich-710	305	4	a.	a.	NOUN
biomedich-710	305	5	,	,	PUNCT
biomedich-710	305	6	prasath	prasath	PROPN
biomedich-710	305	7	,	,	PUNCT
biomedich-710	305	8	r.	r.	PROPN
biomedich-710	305	9	,	,	PUNCT
biomedich-710	305	10	&	&	CCONJ
biomedich-710	305	11	anand	anand	PROPN
biomedich-710	305	12	,	,	PUNCT
biomedich-710	305	13	a.	a.	PROPN
biomedich-710	305	14	(	(	PUNCT
biomedich-710	305	15	2014	2014	NUM
biomedich-710	305	16	)	)	PUNCT
biomedich-710	305	17	.	.	PUNCT
biomedich-710	306	1	the	the	DET
biomedich-710	306	2	medical	medical	ADJ
biomedich-710	306	3	uses	use	NOUN
biomedich-710	306	4	of	of	ADP
biomedich-710	306	5	coccinia	coccinia	PROPN
biomedich-710	306	6	grandis	grandis	PROPN
biomedich-710	306	7	l.	l.	PROPN
biomedich-710	306	8	voigt	voigt	PROPN
biomedich-710	306	9	:	:	PUNCT
biomedich-710	306	10	a	a	DET
biomedich-710	306	11	review	review	NOUN
biomedich-710	306	12	.	.	PUNCT
biomedich-710	307	1	international	international	ADJ
biomedich-710	307	2	journal	journal	PROPN
biomedich-710	307	3	of	of	ADP
biomedich-710	307	4	pharmacognosy	pharmacognosy	NOUN
biomedich-710	307	5	,	,	PUNCT
biomedich-710	307	6	1(11	1(11	NUM
biomedich-710	307	7	)	)	PUNCT
biomedich-710	307	8	,	,	PUNCT
biomedich-710	307	9	681–690	681–690	NUM
biomedich-710	307	10	.	.	NOUN
biomedich-710	308	1	https://doi.org/10.13040/ijpsr.09758232.ijp.1(11).681-90	https://doi.org/10.13040/ijpsr.09758232.ijp.1(11).681-90	X
biomedich-710	308	2	sauvage	sauvage	PROPN
biomedich-710	308	3	,	,	PUNCT
biomedich-710	308	4	e.	e.	PROPN
biomedich-710	308	5	,	,	PUNCT
biomedich-710	308	6	powell	powell	PROPN
biomedich-710	308	7	,	,	PUNCT
biomedich-710	308	8	a.	a.	PROPN
biomedich-710	308	9	j.	j.	PROPN
biomedich-710	308	10	,	,	PUNCT
biomedich-710	308	11	heilemann	heilemann	PROPN
biomedich-710	308	12	,	,	PUNCT
biomedich-710	308	13	j.	j.	PROPN
biomedich-710	308	14	,	,	PUNCT
biomedich-710	308	15	josephine	josephine	PROPN
biomedich-710	308	16	,	,	PUNCT
biomedich-710	308	17	h.	h.	PROPN
biomedich-710	308	18	r.	r.	PROPN
biomedich-710	308	19	,	,	PUNCT
biomedich-710	308	20	charlier	charlier	NOUN
biomedich-710	308	21	,	,	PUNCT
biomedich-710	308	22	p.	p.	NOUN
biomedich-710	308	23	,	,	PUNCT
biomedich-710	308	24	davies	davy	NOUN
biomedich-710	308	25	,	,	PUNCT
biomedich-710	308	26	c.	c.	PROPN
biomedich-710	308	27	,	,	PUNCT
biomedich-710	308	28	&	&	CCONJ
biomedich-710	308	29	pratt	pratt	PROPN
biomedich-710	308	30	,	,	PUNCT
biomedich-710	308	31	r.	r.	PROPN
biomedich-710	308	32	f.	f.	PROPN
biomedich-710	308	33	(	(	PUNCT
biomedich-710	308	34	2008	2008	NUM
biomedich-710	308	35	)	)	PUNCT
biomedich-710	308	36	.	.	PUNCT
biomedich-710	309	1	crystal	crystal	NOUN
biomedich-710	309	2	structures	structure	NOUN
biomedich-710	309	3	of	of	ADP
biomedich-710	309	4	complexes	complex	NOUN
biomedich-710	309	5	of	of	ADP
biomedich-710	309	6	bacterial	bacterial	ADJ
biomedich-710	309	7	dd	dd	NOUN
biomedich-710	309	8	-	-	PUNCT
biomedich-710	309	9	peptidases	peptidase	NOUN
biomedich-710	309	10	with	with	ADP
biomedich-710	309	11	peptidoglycan	peptidoglycan	ADJ
biomedich-710	309	12	-	-	PUNCT
biomedich-710	309	13	mimetic	mimetic	ADJ
biomedich-710	309	14	ligands	ligand	NOUN
biomedich-710	309	15	:	:	PUNCT
biomedich-710	309	16	the	the	DET
biomedich-710	309	17	substrate	substrate	NOUN
biomedich-710	309	18	specificity	specificity	NOUN
biomedich-710	309	19	puzzle	puzzle	NOUN
biomedich-710	309	20	.	.	PUNCT
biomedich-710	310	1	journal	journal	NOUN
biomedich-710	310	2	of	of	ADP
biomedich-710	310	3	molecular	molecular	ADJ
biomedich-710	310	4	biology	biology	NOUN
biomedich-710	310	5	,	,	PUNCT
biomedich-710	310	6	381(2	381(2	NUM
biomedich-710	310	7	)	)	PUNCT
biomedich-710	310	8	,	,	PUNCT
biomedich-710	310	9	383–393	383–393	NUM
biomedich-710	310	10	.	.	PUNCT
biomedich-710	311	1	https://doi.org/10.1016/j.jmb.2008.06.012	https://doi.org/10.1016/j.jmb.2008.06.012	NOUN
biomedich-710	311	2	shivanika	shivanika	NOUN
biomedich-710	311	3	,	,	PUNCT
biomedich-710	311	4	c.	c.	PROPN
biomedich-710	311	5	,	,	PUNCT
biomedich-710	311	6	deepak	deepak	PROPN
biomedich-710	311	7	kumar	kumar	PROPN
biomedich-710	311	8	,	,	PUNCT
biomedich-710	311	9	s.	s.	PROPN
biomedich-710	311	10	,	,	PUNCT
biomedich-710	311	11	ragunathan	ragunathan	PROPN
biomedich-710	311	12	,	,	PUNCT
biomedich-710	311	13	v.	v.	PROPN
biomedich-710	311	14	,	,	PUNCT
biomedich-710	311	15	tiwari	tiwari	PROPN
biomedich-710	311	16	,	,	PUNCT
biomedich-710	311	17	p.	p.	PROPN
biomedich-710	311	18	,	,	PUNCT
biomedich-710	311	19	sumitha	sumitha	PROPN
biomedich-710	311	20	,	,	PUNCT
biomedich-710	311	21	a.	a.	NOUN
biomedich-710	311	22	,	,	PUNCT
biomedich-710	311	23	&	&	CCONJ
biomedich-710	311	24	brindha	brindha	PROPN
biomedich-710	311	25	devi	devi	PROPN
biomedich-710	311	26	,	,	PUNCT
biomedich-710	311	27	p.	p.	NOUN
biomedich-710	311	28	(	(	PUNCT
biomedich-710	311	29	2022	2022	NUM
biomedich-710	311	30	)	)	PUNCT
biomedich-710	311	31	.	.	PUNCT
biomedich-710	312	1	molecular	molecular	ADJ
biomedich-710	312	2	docking	docking	NOUN
biomedich-710	312	3	,	,	PUNCT
biomedich-710	312	4	validation	validation	NOUN
biomedich-710	312	5	,	,	PUNCT
biomedich-710	312	6	dynamics	dynamic	NOUN
biomedich-710	312	7	simulations	simulation	NOUN
biomedich-710	312	8	,	,	PUNCT
biomedich-710	312	9	and	and	CCONJ
biomedich-710	312	10	pharmacokinetic	pharmacokinetic	ADJ
biomedich-710	312	11	prediction	prediction	NOUN
biomedich-710	312	12	of	of	ADP
biomedich-710	312	13	natural	natural	ADJ
biomedich-710	312	14	compounds	compound	NOUN
biomedich-710	312	15	against	against	ADP
biomedich-710	312	16	the	the	DET
biomedich-710	312	17	sars	sar	NOUN
biomedich-710	312	18	-	-	PUNCT
biomedich-710	312	19	cov-2	cov-2	NOUN
biomedich-710	312	20	main	main	ADJ
biomedich-710	312	21	-	-	PUNCT
biomedich-710	312	22	protease	protease	NOUN
biomedich-710	312	23	.	.	PUNCT
biomedich-710	313	1	journal	journal	NOUN
biomedich-710	313	2	of	of	ADP
biomedich-710	313	3	biomolecular	biomolecular	ADJ
biomedich-710	313	4	structure	structure	NOUN
biomedich-710	313	5	and	and	CCONJ
biomedich-710	313	6	dynamics	dynamic	NOUN
biomedich-710	313	7	,	,	PUNCT
biomedich-710	313	8	40(2	40(2	NUM
biomedich-710	313	9	)	)	PUNCT
biomedich-710	313	10	,	,	PUNCT
biomedich-710	313	11	585–611	585–611	NUM
biomedich-710	313	12	.	.	PUNCT
biomedich-710	314	1	https://doi.org/10.1080/07391102.2020.1815584	https://doi.org/10.1080/07391102.2020.1815584	PROPN
biomedich-710	314	2	veber	veber	PROPN
biomedich-710	314	3	,	,	PUNCT
biomedich-710	314	4	d.	d.	PROPN
biomedich-710	314	5	f.	f.	PROPN
biomedich-710	314	6	,	,	PUNCT
biomedich-710	314	7	johnson	johnson	PROPN
biomedich-710	314	8	,	,	PUNCT
biomedich-710	314	9	s.	s.	PROPN
biomedich-710	314	10	r.	r.	PROPN
biomedich-710	314	11	,	,	PUNCT
biomedich-710	314	12	cheng	cheng	PROPN
biomedich-710	314	13	,	,	PUNCT
biomedich-710	314	14	h.	h.	PROPN
biomedich-710	314	15	y.	y.	PROPN
biomedich-710	314	16	,	,	PUNCT
biomedich-710	314	17	smith	smith	PROPN
biomedich-710	314	18	,	,	PUNCT
biomedich-710	314	19	b.	b.	PROPN
biomedich-710	314	20	r.	r.	PROPN
biomedich-710	314	21	,	,	PUNCT
biomedich-710	314	22	ward	ward	PROPN
biomedich-710	314	23	,	,	PUNCT
biomedich-710	314	24	k.	k.	PROPN
biomedich-710	314	25	w.	w.	PROPN
biomedich-710	314	26	,	,	PUNCT
biomedich-710	314	27	&	&	CCONJ
biomedich-710	314	28	kopple	kopple	PROPN
biomedich-710	314	29	,	,	PUNCT
biomedich-710	314	30	k.	k.	PROPN
biomedich-710	314	31	d.	d.	PROPN
biomedich-710	314	32	(	(	PUNCT
biomedich-710	314	33	2002	2002	NUM
biomedich-710	314	34	)	)	PUNCT
biomedich-710	314	35	.	.	PUNCT
biomedich-710	315	1	molecular	molecular	ADJ
biomedich-710	315	2	properties	property	NOUN
biomedich-710	315	3	that	that	PRON
biomedich-710	315	4	influence	influence	VERB
biomedich-710	315	5	the	the	DET
biomedich-710	315	6	oral	oral	ADJ
biomedich-710	315	7	bioavailability	bioavailability	NOUN
biomedich-710	315	8	of	of	ADP
biomedich-710	315	9	drug	drug	NOUN
biomedich-710	315	10	candidates	candidate	NOUN
biomedich-710	315	11	.	.	PUNCT
biomedich-710	316	1	journal	journal	NOUN
biomedich-710	316	2	of	of	ADP
biomedich-710	316	3	medicinal	medicinal	ADJ
biomedich-710	316	4	chemistry	chemistry	NOUN
biomedich-710	316	5	,	,	PUNCT
biomedich-710	316	6	45(12	45(12	NUM
biomedich-710	316	7	)	)	PUNCT
biomedich-710	316	8	,	,	PUNCT
biomedich-710	316	9	2615–2623	2615–2623	NUM
biomedich-710	316	10	.	.	PUNCT
biomedich-710	317	1	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	PROPN
biomedich-710	317	2	zhang	zhang	PROPN
biomedich-710	317	3	,	,	PUNCT
biomedich-710	317	4	w.	w.	PROPN
biomedich-710	317	5	,	,	PUNCT
biomedich-710	317	6	shi	shi	PROPN
biomedich-710	317	7	,	,	PUNCT
biomedich-710	317	8	q.	q.	PROPN
biomedich-710	317	9	,	,	PUNCT
biomedich-710	317	10	meroueh	meroueh	PROPN
biomedich-710	317	11	,	,	PUNCT
biomedich-710	317	12	s.	s.	PROPN
biomedich-710	317	13	o.	o.	PROPN
biomedich-710	317	14	,	,	PUNCT
biomedich-710	317	15	vakulenko	vakulenko	PROPN
biomedich-710	317	16	,	,	PUNCT
biomedich-710	317	17	s.	s.	PROPN
biomedich-710	317	18	b.	b.	PROPN
biomedich-710	317	19	,	,	PUNCT
biomedich-710	317	20	&	&	CCONJ
biomedich-710	317	21	mobashery	mobashery	NOUN
biomedich-710	317	22	,	,	PUNCT
biomedich-710	317	23	s.	s.	PROPN
biomedich-710	317	24	(	(	PUNCT
biomedich-710	317	25	2007	2007	NUM
biomedich-710	317	26	)	)	PUNCT
biomedich-710	317	27	.	.	PUNCT
biomedich-710	318	1	catalytic	catalytic	ADJ
biomedich-710	318	2	mechanism	mechanism	NOUN
biomedich-710	318	3	of	of	ADP
biomedich-710	318	4	penicillinbinding	penicillinbinde	VERB
biomedich-710	318	5	protein	protein	NOUN
biomedich-710	318	6	5	5	NUM
biomedich-710	318	7	of	of	ADP
biomedich-710	318	8	escherichia	escherichia	NOUN
biomedich-710	318	9	coli	coli	NOUN
biomedich-710	318	10	.	.	PUNCT
biomedich-710	319	1	biochemistry	biochemistry	NOUN
biomedich-710	319	2	,	,	PUNCT
biomedich-710	319	3	46(35	46(35	PROPN
biomedich-710	319	4	)	)	PUNCT
biomedich-710	319	5	,	,	PUNCT
biomedich-710	319	6	10113–10121	10113–10121	NUM
biomedich-710	319	7	.	.	PUNCT
biomedich-710	320	1	https://doi.org/10.1021/bi700777x	https://doi.org/10.1021/bi700777x	PROPN
biomedich-710	320	2	zheng	zheng	PROPN
biomedich-710	320	3	,	,	PUNCT
biomedich-710	320	4	x.	x.	PROPN
biomedich-710	320	5	,	,	PUNCT
biomedich-710	320	6	&	&	CCONJ
biomedich-710	320	7	polli	polli	PROPN
biomedich-710	320	8	,	,	PUNCT
biomedich-710	320	9	j.	j.	PROPN
biomedich-710	320	10	(	(	PUNCT
biomedich-710	320	11	2010	2010	NUM
biomedich-710	320	12	)	)	PUNCT
biomedich-710	320	13	.	.	PUNCT
biomedich-710	321	1	identification	identification	NOUN
biomedich-710	321	2	of	of	ADP
biomedich-710	321	3	inhibitor	inhibitor	NOUN
biomedich-710	321	4	concentrations	concentration	NOUN
biomedich-710	321	5	to	to	PART
biomedich-710	321	6	efficiently	efficiently	ADV
biomedich-710	321	7	screen	screen	VERB
biomedich-710	321	8	and	and	CCONJ
biomedich-710	321	9	measure	measure	NOUN
biomedich-710	321	10	inhibition	inhibition	NOUN
biomedich-710	321	11	ki	ki	PROPN
biomedich-710	321	12	values	value	NOUN
biomedich-710	321	13	against	against	ADP
biomedich-710	321	14	solute	solute	NOUN
biomedich-710	321	15	carrier	carrier	NOUN
biomedich-710	321	16	transporters	transporter	NOUN
biomedich-710	321	17	.	.	PUNCT
biomedich-710	322	1	european	european	ADJ
biomedich-710	322	2	journal	journal	PROPN
biomedich-710	322	3	of	of	ADP
biomedich-710	322	4	pharmaceutical	pharmaceutical	NOUN
biomedich-710	322	5	sciences	science	NOUN
biomedich-710	322	6	,	,	PUNCT
biomedich-710	322	7	41(1	41(1	NUM
biomedich-710	322	8	)	)	PUNCT
biomedich-710	322	9	,	,	PUNCT
biomedich-710	322	10	43–52	43–52	NUM
biomedich-710	322	11	.	.	PUNCT
biomedich-710	323	1	https://doi.org/10.1016/j.ejps.2010.05.013	https://doi.org/10.1016/j.ejps.2010.05.013	PROPN