id	sid	tid	token	lemma	pos
biomedich-729	1	1	biology	biology	NOUN
biomedich-729	1	2	,	,	PUNCT
biomedich-729	1	3	medicine	medicine	NOUN
biomedich-729	1	4	,	,	PUNCT
biomedich-729	1	5	&	&	CCONJ
biomedich-729	1	6	natural	natural	ADJ
biomedich-729	1	7	product	product	NOUN
biomedich-729	1	8	chemistry	chemistry	NOUN
biomedich-729	1	9	issn	issn	VERB
biomedich-729	1	10	2089	2089	NUM
biomedich-729	1	11	-	-	SYM
biomedich-729	1	12	6514	6514	NUM
biomedich-729	1	13	(	(	PUNCT
biomedich-729	1	14	paper	paper	NOUN
biomedich-729	1	15	)	)	PUNCT
biomedich-729	1	16	volume	volume	NOUN
biomedich-729	1	17	14	14	NUM
biomedich-729	1	18	,	,	PUNCT
biomedich-729	1	19	number	number	NOUN
biomedich-729	1	20	1	1	NUM
biomedich-729	1	21	,	,	PUNCT
biomedich-729	1	22	april	april	PROPN
biomedich-729	1	23	2025	2025	NUM
biomedich-729	1	24	|	|	ADV
biomedich-729	1	25	pages	page	NOUN
biomedich-729	1	26	:	:	PUNCT
biomedich-729	1	27	369	369	NUM
biomedich-729	1	28	-	-	SYM
biomedich-729	1	29	379	379	NUM
biomedich-729	1	30	|	|	ADV
biomedich-729	1	31	doi	doi	NOUN
biomedich-729	1	32	:	:	PUNCT
biomedich-729	1	33	10.14421	10.14421	NUM
biomedich-729	1	34	/	/	SYM
biomedich-729	1	35	biomedich.2025.141.369	biomedich.2025.141.369	PROPN
biomedich-729	1	36	-	-	PUNCT
biomedich-729	1	37	379	379	NUM
biomedich-729	1	38	issn	issn	PROPN
biomedich-729	1	39	2540	2540	NUM
biomedich-729	1	40	-	-	SYM
biomedich-729	1	41	9328	9328	NUM
biomedich-729	1	42	(	(	PUNCT
biomedich-729	1	43	online	online	ADV
biomedich-729	1	44	)	)	PUNCT
biomedich-729	1	45	in	in	ADP
biomedich-729	1	46	silico	silico	NOUN
biomedich-729	1	47	toxicity	toxicity	NOUN
biomedich-729	1	48	prediction	prediction	NOUN
biomedich-729	1	49	of	of	ADP
biomedich-729	1	50	ethanol	ethanol	NOUN
biomedich-729	1	51	extract	extract	NOUN
biomedich-729	1	52	of	of	ADP
biomedich-729	1	53	cola	cola	PROPN
biomedich-729	1	54	rostrata	rostrata	PROPN
biomedich-729	1	55	(	(	PUNCT
biomedich-729	1	56	k.	k.	PROPN
biomedich-729	1	57	schum	schum	PROPN
biomedich-729	1	58	.	.	PUNCT
biomedich-729	1	59	)	)	PUNCT
biomedich-729	2	1	epicarp	epicarp	ADJ
biomedich-729	2	2	babatunde	babatunde	PROPN
biomedich-729	2	3	ebenezer	ebenezer	PROPN
biomedich-729	2	4	ajayi1	ajayi1	PROPN
biomedich-729	2	5	,	,	PUNCT
biomedich-729	2	6	*	*	PROPN
biomedich-729	2	7	,	,	PUNCT
biomedich-729	2	8	oluwafemi	oluwafemi	NOUN
biomedich-729	2	9	segun	segun	VERB
biomedich-729	2	10	aina1	aina1	PROPN
biomedich-729	2	11	,	,	PUNCT
biomedich-729	2	12	albert	albert	PROPN
biomedich-729	2	13	kolawole	kolawole	PROPN
biomedich-729	2	14	odunlade1,2	odunlade1,2	PROPN
biomedich-729	2	15	,	,	PUNCT
biomedich-729	2	16	bamidele	bamidele	PROPN
biomedich-729	2	17	joseph	joseph	PROPN
biomedich-729	2	18	minari3	minari3	PROPN
biomedich-729	3	1	1department	1department	NUM
biomedich-729	3	2	biological	biological	ADJ
biomedich-729	3	3	sciences	science	NOUN
biomedich-729	3	4	,	,	PUNCT
biomedich-729	3	5	faculty	faculty	NOUN
biomedich-729	3	6	of	of	ADP
biomedich-729	3	7	basic	basic	ADJ
biomedich-729	3	8	medical	medical	ADJ
biomedich-729	3	9	and	and	CCONJ
biomedich-729	3	10	applied	applied	ADJ
biomedich-729	3	11	sciences	science	NOUN
biomedich-729	3	12	,	,	PUNCT
biomedich-729	3	13	trinity	trinity	NOUN
biomedich-729	3	14	university	university	PROPN
biomedich-729	3	15	,	,	PUNCT
biomedich-729	3	16	nigeria	nigeria	PROPN
biomedich-729	3	17	.	.	PUNCT
biomedich-729	4	1	2department	2department	NUM
biomedich-729	4	2	of	of	ADP
biomedich-729	4	3	science	science	NOUN
biomedich-729	4	4	laboratory	laboratory	NOUN
biomedich-729	4	5	technology	technology	NOUN
biomedich-729	4	6	,	,	PUNCT
biomedich-729	4	7	school	school	NOUN
biomedich-729	4	8	of	of	ADP
biomedich-729	4	9	science	science	NOUN
biomedich-729	4	10	,	,	PUNCT
biomedich-729	4	11	yaba	yaba	PROPN
biomedich-729	4	12	college	college	PROPN
biomedich-729	4	13	of	of	ADP
biomedich-729	4	14	technology	technology	PROPN
biomedich-729	4	15	,	,	PUNCT
biomedich-729	4	16	nigeria	nigeria	PROPN
biomedich-729	4	17	.	.	PUNCT
biomedich-729	5	1	3department	3department	NUM
biomedich-729	5	2	of	of	ADP
biomedich-729	5	3	cell	cell	NOUN
biomedich-729	5	4	biology	biology	NOUN
biomedich-729	5	5	and	and	CCONJ
biomedich-729	5	6	genetics	genetic	NOUN
biomedich-729	5	7	,	,	PUNCT
biomedich-729	5	8	faculty	faculty	NOUN
biomedich-729	5	9	of	of	ADP
biomedich-729	5	10	science	science	NOUN
biomedich-729	5	11	,	,	PUNCT
biomedich-729	5	12	university	university	NOUN
biomedich-729	5	13	of	of	ADP
biomedich-729	5	14	lagos	lagos	PROPN
biomedich-729	5	15	,	,	PUNCT
biomedich-729	5	16	nigeria	nigeria	PROPN
biomedich-729	5	17	.	.	PUNCT
biomedich-729	6	1	corresponding	correspond	VERB
biomedich-729	6	2	author	author	NOUN
biomedich-729	6	3	*	*	PUNCT
biomedich-729	6	4	tobitune@yahoo.com	tobitune@yahoo.com	X
biomedich-729	7	1	abstract	abstract	ADJ
biomedich-729	7	2	the	the	DET
biomedich-729	7	3	ethanol	ethanol	NOUN
biomedich-729	7	4	extract	extract	NOUN
biomedich-729	7	5	of	of	ADP
biomedich-729	7	6	the	the	DET
biomedich-729	7	7	epicarp	epicarp	NOUN
biomedich-729	7	8	of	of	ADP
biomedich-729	7	9	cola	cola	PROPN
biomedich-729	7	10	rostrata	rostrata	NOUN
biomedich-729	7	11	fruit	fruit	NOUN
biomedich-729	7	12	has	have	AUX
biomedich-729	7	13	been	be	AUX
biomedich-729	7	14	reported	report	VERB
biomedich-729	7	15	to	to	PART
biomedich-729	7	16	possess	possess	VERB
biomedich-729	7	17	notable	notable	ADJ
biomedich-729	7	18	pharmacological	pharmacological	ADJ
biomedich-729	7	19	properties	property	NOUN
biomedich-729	7	20	,	,	PUNCT
biomedich-729	7	21	including	include	VERB
biomedich-729	7	22	anticancer	anticancer	NOUN
biomedich-729	7	23	,	,	PUNCT
biomedich-729	7	24	anti	anti	ADJ
biomedich-729	7	25	-	-	ADJ
biomedich-729	7	26	inflammatory	inflammatory	ADJ
biomedich-729	7	27	and	and	CCONJ
biomedich-729	7	28	antidiabetic	antidiabetic	ADJ
biomedich-729	7	29	effects	effect	NOUN
biomedich-729	7	30	;	;	PUNCT
biomedich-729	7	31	however	however	ADV
biomedich-729	7	32	,	,	PUNCT
biomedich-729	7	33	its	its	PRON
biomedich-729	7	34	toxicological	toxicological	ADJ
biomedich-729	7	35	profile	profile	NOUN
biomedich-729	7	36	remains	remain	VERB
biomedich-729	7	37	understudied	understudied	ADJ
biomedich-729	7	38	.	.	PUNCT
biomedich-729	8	1	this	this	DET
biomedich-729	8	2	study	study	NOUN
biomedich-729	8	3	evaluated	evaluate	VERB
biomedich-729	8	4	the	the	DET
biomedich-729	8	5	metabolism	metabolism	NOUN
biomedich-729	8	6	,	,	PUNCT
biomedich-729	8	7	excretion	excretion	NOUN
biomedich-729	8	8	and	and	CCONJ
biomedich-729	8	9	toxicity	toxicity	NOUN
biomedich-729	8	10	properties	property	NOUN
biomedich-729	8	11	of	of	ADP
biomedich-729	8	12	gas	gas	NOUN
biomedich-729	8	13	chromatography	chromatography	NOUN
biomedich-729	8	14	-	-	PUNCT
biomedich-729	8	15	mass	mass	NOUN
biomedich-729	8	16	spectroscopy	spectroscopy	NOUN
biomedich-729	8	17	-	-	PUNCT
biomedich-729	8	18	identified	identify	VERB
biomedich-729	8	19	phytochemicals	phytochemical	NOUN
biomedich-729	8	20	from	from	ADP
biomedich-729	8	21	c.	c.	PROPN
biomedich-729	8	22	rostrata	rostrata	PROPN
biomedich-729	8	23	epicarp	epicarp	ADJ
biomedich-729	8	24	.	.	PUNCT
biomedich-729	9	1	in	in	ADP
biomedich-729	9	2	silico	silico	NOUN
biomedich-729	9	3	analysis	analysis	NOUN
biomedich-729	9	4	and	and	CCONJ
biomedich-729	9	5	molecular	molecular	ADJ
biomedich-729	9	6	docking	docking	NOUN
biomedich-729	9	7	of	of	ADP
biomedich-729	9	8	components	component	NOUN
biomedich-729	9	9	were	be	AUX
biomedich-729	9	10	carried	carry	VERB
biomedich-729	9	11	out	out	ADP
biomedich-729	9	12	using	use	VERB
biomedich-729	9	13	the	the	DET
biomedich-729	9	14	admetlab2.0	admetlab2.0	ADJ
biomedich-729	9	15	platform	platform	NOUN
biomedich-729	9	16	and	and	CCONJ
biomedich-729	9	17	autodock4	autodock4	PROPN
biomedich-729	9	18	tools	tool	NOUN
biomedich-729	9	19	.	.	PUNCT
biomedich-729	10	1	visualization	visualization	NOUN
biomedich-729	10	2	of	of	ADP
biomedich-729	10	3	molecular	molecular	ADJ
biomedich-729	10	4	binding	bind	VERB
biomedich-729	10	5	interactions	interaction	NOUN
biomedich-729	10	6	was	be	AUX
biomedich-729	10	7	done	do	VERB
biomedich-729	10	8	using	use	VERB
biomedich-729	10	9	discovery	discovery	NOUN
biomedich-729	10	10	studio-2020	studio-2020	NOUN
biomedich-729	10	11	.	.	PUNCT
biomedich-729	11	1	ten	ten	NUM
biomedich-729	11	2	of	of	ADP
biomedich-729	11	3	the	the	DET
biomedich-729	11	4	48	48	NUM
biomedich-729	11	5	compounds	compound	NOUN
biomedich-729	11	6	in	in	ADP
biomedich-729	11	7	the	the	DET
biomedich-729	11	8	extract	extract	NOUN
biomedich-729	11	9	,	,	PUNCT
biomedich-729	11	10	including	include	VERB
biomedich-729	11	11	1-(4	1-(4	NUM
biomedich-729	11	12	-	-	PUNCT
biomedich-729	11	13	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	11	14	-	-	PUNCT
biomedich-729	11	15	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	11	16	,	,	PUNCT
biomedich-729	11	17	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	11	18	-	-	PUNCT
biomedich-729	11	19	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	11	20	.	.	NUM
biomedich-729	11	21	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	11	22	and	and	CCONJ
biomedich-729	11	23	2	2	X
biomedich-729	11	24	-	-	PUNCT
biomedich-729	11	25	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	11	26	,	,	PUNCT
biomedich-729	11	27	were	be	AUX
biomedich-729	11	28	predicted	predict	VERB
biomedich-729	11	29	to	to	PART
biomedich-729	11	30	have	have	VERB
biomedich-729	11	31	high	high	ADJ
biomedich-729	11	32	probability	probability	NOUN
biomedich-729	11	33	of	of	ADP
biomedich-729	11	34	inducing	induce	VERB
biomedich-729	11	35	liver	liver	NOUN
biomedich-729	11	36	injury	injury	NOUN
biomedich-729	11	37	,	,	PUNCT
biomedich-729	11	38	oxidative	oxidative	ADJ
biomedich-729	11	39	stress	stress	NOUN
biomedich-729	11	40	and	and	CCONJ
biomedich-729	11	41	inhibiting	inhibit	VERB
biomedich-729	11	42	cytochrome	cytochrome	NOUN
biomedich-729	11	43	-	-	PUNCT
biomedich-729	11	44	p450	p450	NUM
biomedich-729	11	45	enzymes	enzyme	NOUN
biomedich-729	11	46	.	.	PUNCT
biomedich-729	12	1	molecular	molecular	ADJ
biomedich-729	12	2	docking	docking	NOUN
biomedich-729	12	3	revealed	reveal	VERB
biomedich-729	12	4	that	that	SCONJ
biomedich-729	12	5	1-(4	1-(4	NUM
biomedich-729	12	6	-	-	PUNCT
biomedich-729	12	7	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	12	8	-	-	PUNCT
biomedich-729	12	9	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	12	10	binds	bind	VERB
biomedich-729	12	11	strongly	strongly	ADV
biomedich-729	12	12	to	to	PART
biomedich-729	12	13	nadh	nadh	VERB
biomedich-729	12	14	dehydrogenase	dehydrogenase	NOUN
biomedich-729	12	15	1	1	NUM
biomedich-729	12	16	(	(	PUNCT
biomedich-729	12	17	-7.78	-7.78	NOUN
biomedich-729	12	18	kcal	kcal	PROPN
biomedich-729	12	19	/	/	SYM
biomedich-729	12	20	mol	mol	NOUN
biomedich-729	12	21	)	)	PUNCT
biomedich-729	12	22	and	and	CCONJ
biomedich-729	12	23	cyp2c19	cyp2c19	PROPN
biomedich-729	12	24	(	(	PUNCT
biomedich-729	12	25	-9.93	-9.93	PROPN
biomedich-729	12	26	kcal	kcal	PROPN
biomedich-729	12	27	/	/	SYM
biomedich-729	12	28	mol	mol	NOUN
biomedich-729	12	29	)	)	PUNCT
biomedich-729	12	30	,	,	PUNCT
biomedich-729	12	31	with	with	ADP
biomedich-729	12	32	the	the	DET
biomedich-729	12	33	compound	compound	NOUN
biomedich-729	12	34	interacting	interact	VERB
biomedich-729	12	35	with	with	ADP
biomedich-729	12	36	thr301	thr301	PROPN
biomedich-729	12	37	,	,	PUNCT
biomedich-729	12	38	leu361	leu361	NOUN
biomedich-729	12	39	and	and	CCONJ
biomedich-729	12	40	leu366	leu366	VERB
biomedich-729	12	41	at	at	ADP
biomedich-729	12	42	the	the	DET
biomedich-729	12	43	active	active	ADJ
biomedich-729	12	44	site	site	NOUN
biomedich-729	12	45	of	of	ADP
biomedich-729	12	46	cyp2c19	cyp2c19	PROPN
biomedich-729	12	47	.	.	PROPN
biomedich-729	13	1	2	2	NUM
biomedich-729	13	2	-	-	PUNCT
biomedich-729	13	3	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	13	4	binds	bind	VERB
biomedich-729	13	5	strongly	strongly	ADV
biomedich-729	13	6	to	to	PART
biomedich-729	13	7	cyp2c19	cyp2c19	PROPN
biomedich-729	13	8	(	(	PUNCT
biomedich-729	13	9	-8.07	-8.07	NOUN
biomedich-729	13	10	kcal	kcal	PROPN
biomedich-729	13	11	/	/	SYM
biomedich-729	13	12	mol	mol	NOUN
biomedich-729	13	13	)	)	PUNCT
biomedich-729	13	14	and	and	CCONJ
biomedich-729	13	15	to	to	ADP
biomedich-729	13	16	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	13	17	(	(	PUNCT
biomedich-729	13	18	-7.49	-7.49	ADP
biomedich-729	13	19	kcal	kcal	PROPN
biomedich-729	13	20	/	/	SYM
biomedich-729	13	21	mol	mol	NOUN
biomedich-729	13	22	)	)	PUNCT
biomedich-729	13	23	,	,	PUNCT
biomedich-729	13	24	while	while	SCONJ
biomedich-729	13	25	,	,	PUNCT
biomedich-729	13	26	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	13	27	-	-	PUNCT
biomedich-729	13	28	trien14.alpha	trien14.alpha	PROPN
biomedich-729	13	29	.	.	PUNCT
biomedich-729	14	1	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	14	2	binds	bind	VERB
biomedich-729	14	3	strongly	strongly	ADV
biomedich-729	14	4	to	to	PART
biomedich-729	14	5	cyp2c19	cyp2c19	PROPN
biomedich-729	14	6	(	(	PUNCT
biomedich-729	14	7	-9.56	-9.56	NOUN
biomedich-729	14	8	kcal	kcal	PROPN
biomedich-729	14	9	/	/	SYM
biomedich-729	14	10	mol	mol	NOUN
biomedich-729	14	11	)	)	PUNCT
biomedich-729	14	12	and	and	CCONJ
biomedich-729	14	13	cyp1a2	cyp1a2	PROPN
biomedich-729	14	14	(	(	PUNCT
biomedich-729	14	15	-8.71	-8.71	NUM
biomedich-729	14	16	kcal	kcal	PROPN
biomedich-729	14	17	/	/	SYM
biomedich-729	14	18	mol	mol	NOUN
biomedich-729	14	19	)	)	PUNCT
biomedich-729	14	20	.	.	PUNCT
biomedich-729	15	1	the	the	DET
biomedich-729	15	2	extract	extract	NOUN
biomedich-729	15	3	showed	show	VERB
biomedich-729	15	4	strong	strong	ADJ
biomedich-729	15	5	potential	potential	NOUN
biomedich-729	15	6	to	to	PART
biomedich-729	15	7	induce	induce	VERB
biomedich-729	15	8	toxic	toxic	ADJ
biomedich-729	15	9	outcomes	outcome	NOUN
biomedich-729	15	10	.	.	PUNCT
biomedich-729	16	1	the	the	DET
biomedich-729	16	2	abundance	abundance	NOUN
biomedich-729	16	3	of	of	ADP
biomedich-729	16	4	antioxidant	antioxidant	ADJ
biomedich-729	16	5	phytosterols	phytosterol	NOUN
biomedich-729	16	6	in	in	ADP
biomedich-729	16	7	the	the	DET
biomedich-729	16	8	extract	extract	NOUN
biomedich-729	16	9	may	may	AUX
biomedich-729	16	10	counterbalance	counterbalance	VERB
biomedich-729	16	11	the	the	DET
biomedich-729	16	12	potential	potential	ADJ
biomedich-729	16	13	toxicity	toxicity	NOUN
biomedich-729	16	14	.	.	PUNCT
biomedich-729	17	1	while	while	SCONJ
biomedich-729	17	2	c.	c.	PROPN
biomedich-729	17	3	rostrata	rostrata	PROPN
biomedich-729	17	4	holds	hold	VERB
biomedich-729	17	5	therapeutic	therapeutic	ADJ
biomedich-729	17	6	potential	potential	NOUN
biomedich-729	17	7	,	,	PUNCT
biomedich-729	17	8	molecular	molecular	ADJ
biomedich-729	17	9	interactions	interaction	NOUN
biomedich-729	17	10	of	of	ADP
biomedich-729	17	11	its	its	PRON
biomedich-729	17	12	phytochemicals	phytochemical	NOUN
biomedich-729	17	13	highlight	highlight	VERB
biomedich-729	17	14	risks	risk	NOUN
biomedich-729	17	15	of	of	ADP
biomedich-729	17	16	toxicity	toxicity	NOUN
biomedich-729	17	17	.	.	PUNCT
biomedich-729	18	1	keywords	keyword	NOUN
biomedich-729	18	2	:	:	PUNCT
biomedich-729	18	3	cola	cola	PROPN
biomedich-729	18	4	rostrata	rostrata	NOUN
biomedich-729	18	5	;	;	PUNCT
biomedich-729	18	6	phytochemicals	phytochemical	NOUN
biomedich-729	18	7	;	;	PUNCT
biomedich-729	18	8	metabolism	metabolism	NOUN
biomedich-729	18	9	;	;	PUNCT
biomedich-729	18	10	toxicity	toxicity	NOUN
biomedich-729	18	11	profile	profile	NOUN
biomedich-729	18	12	;	;	PUNCT
biomedich-729	18	13	gc	gc	PROPN
biomedich-729	18	14	-	-	PUNCT
biomedich-729	18	15	ms	ms	NOUN
biomedich-729	18	16	;	;	PUNCT
biomedich-729	18	17	molecular	molecular	ADJ
biomedich-729	18	18	docking	docking	NOUN
biomedich-729	18	19	.	.	PUNCT
biomedich-729	19	1	introduction	introduction	NOUN
biomedich-729	19	2	a	a	DET
biomedich-729	19	3	large	large	ADJ
biomedich-729	19	4	majority	majority	NOUN
biomedich-729	19	5	of	of	ADP
biomedich-729	19	6	people	people	NOUN
biomedich-729	19	7	in	in	ADP
biomedich-729	19	8	developing	develop	VERB
biomedich-729	19	9	areas	area	NOUN
biomedich-729	19	10	of	of	ADP
biomedich-729	19	11	the	the	DET
biomedich-729	19	12	world	world	NOUN
biomedich-729	19	13	depend	depend	VERB
biomedich-729	19	14	on	on	ADP
biomedich-729	19	15	natural	natural	ADJ
biomedich-729	19	16	products	product	NOUN
biomedich-729	19	17	for	for	ADP
biomedich-729	19	18	the	the	DET
biomedich-729	19	19	treatment	treatment	NOUN
biomedich-729	19	20	and	and	CCONJ
biomedich-729	19	21	management	management	NOUN
biomedich-729	19	22	of	of	ADP
biomedich-729	19	23	various	various	ADJ
biomedich-729	19	24	diseases	disease	NOUN
biomedich-729	19	25	and	and	CCONJ
biomedich-729	19	26	illnesses	illness	NOUN
biomedich-729	19	27	(	(	PUNCT
biomedich-729	19	28	ekor	ekor	ADJ
biomedich-729	19	29	,	,	PUNCT
biomedich-729	19	30	2014	2014	NUM
biomedich-729	19	31	;	;	PUNCT
biomedich-729	19	32	mintah	mintah	ADP
biomedich-729	19	33	et	et	PROPN
biomedich-729	19	34	al	al	PROPN
biomedich-729	19	35	.	.	PROPN
biomedich-729	19	36	,	,	PUNCT
biomedich-729	19	37	2022	2022	NUM
biomedich-729	19	38	)	)	PUNCT
biomedich-729	19	39	.	.	PUNCT
biomedich-729	20	1	the	the	DET
biomedich-729	20	2	current	current	ADJ
biomedich-729	20	3	global	global	ADJ
biomedich-729	20	4	hike	hike	NOUN
biomedich-729	20	5	in	in	ADP
biomedich-729	20	6	the	the	DET
biomedich-729	20	7	prices	price	NOUN
biomedich-729	20	8	of	of	ADP
biomedich-729	20	9	clinically	clinically	ADV
biomedich-729	20	10	used	use	VERB
biomedich-729	20	11	drugs	drug	NOUN
biomedich-729	20	12	,	,	PUNCT
biomedich-729	20	13	chemotherapeutic	chemotherapeutic	ADJ
biomedich-729	20	14	drugs	drug	NOUN
biomedich-729	20	15	in	in	ADP
biomedich-729	20	16	particular	particular	ADJ
biomedich-729	20	17	,	,	PUNCT
biomedich-729	20	18	is	be	AUX
biomedich-729	20	19	making	make	VERB
biomedich-729	20	20	more	more	ADJ
biomedich-729	20	21	people	people	NOUN
biomedich-729	20	22	choose	choose	VERB
biomedich-729	20	23	plant	plant	NOUN
biomedich-729	20	24	-	-	PUNCT
biomedich-729	20	25	based	base	VERB
biomedich-729	20	26	remedies	remedy	NOUN
biomedich-729	20	27	,	,	PUNCT
biomedich-729	20	28	owing	owe	VERB
biomedich-729	20	29	to	to	ADP
biomedich-729	20	30	their	their	PRON
biomedich-729	20	31	affordability	affordability	NOUN
biomedich-729	20	32	,	,	PUNCT
biomedich-729	20	33	accessibility	accessibility	NOUN
biomedich-729	20	34	,	,	PUNCT
biomedich-729	20	35	and	and	CCONJ
biomedich-729	20	36	availability	availability	NOUN
biomedich-729	20	37	(	(	PUNCT
biomedich-729	20	38	shin	shin	NOUN
biomedich-729	20	39	et	et	PROPN
biomedich-729	20	40	al	al	PROPN
biomedich-729	20	41	.	.	PROPN
biomedich-729	20	42	,	,	PUNCT
biomedich-729	20	43	2022	2022	NUM
biomedich-729	20	44	;	;	PUNCT
biomedich-729	20	45	serra	serra	PROPN
biomedich-729	20	46	-	-	PUNCT
biomedich-729	20	47	burriel	burriel	PROPN
biomedich-729	20	48	et	et	PROPN
biomedich-729	20	49	al	al	PROPN
biomedich-729	20	50	.	.	PROPN
biomedich-729	20	51	,	,	PUNCT
biomedich-729	20	52	2023	2023	NUM
biomedich-729	20	53	;	;	PUNCT
biomedich-729	20	54	vasques	vasque	NOUN
biomedich-729	20	55	et	et	PROPN
biomedich-729	20	56	al	al	PROPN
biomedich-729	20	57	.	.	PROPN
biomedich-729	20	58	,	,	PUNCT
biomedich-729	20	59	2023	2023	NUM
biomedich-729	20	60	)	)	PUNCT
biomedich-729	20	61	.	.	PUNCT
biomedich-729	21	1	plants	plant	NOUN
biomedich-729	21	2	have	have	AUX
biomedich-729	21	3	proven	prove	VERB
biomedich-729	21	4	to	to	PART
biomedich-729	21	5	be	be	AUX
biomedich-729	21	6	a	a	DET
biomedich-729	21	7	viable	viable	ADJ
biomedich-729	21	8	source	source	NOUN
biomedich-729	21	9	of	of	ADP
biomedich-729	21	10	bioactive	bioactive	ADJ
biomedich-729	21	11	compounds	compound	NOUN
biomedich-729	21	12	that	that	PRON
biomedich-729	21	13	have	have	AUX
biomedich-729	21	14	been	be	AUX
biomedich-729	21	15	developed	develop	VERB
biomedich-729	21	16	into	into	ADP
biomedich-729	21	17	drugs	drug	NOUN
biomedich-729	21	18	for	for	ADP
biomedich-729	21	19	treating	treat	VERB
biomedich-729	21	20	several	several	ADJ
biomedich-729	21	21	disease	disease	NOUN
biomedich-729	21	22	conditions	condition	NOUN
biomedich-729	21	23	(	(	PUNCT
biomedich-729	21	24	newman	newman	PROPN
biomedich-729	21	25	&	&	CCONJ
biomedich-729	21	26	cragg	cragg	PROPN
biomedich-729	21	27	,	,	PUNCT
biomedich-729	21	28	2020	2020	NUM
biomedich-729	21	29	)	)	PUNCT
biomedich-729	21	30	.	.	PUNCT
biomedich-729	22	1	the	the	DET
biomedich-729	22	2	increase	increase	NOUN
biomedich-729	22	3	in	in	ADP
biomedich-729	22	4	the	the	DET
biomedich-729	22	5	usage	usage	NOUN
biomedich-729	22	6	of	of	ADP
biomedich-729	22	7	plant	plant	NOUN
biomedich-729	22	8	remedies	remedy	NOUN
biomedich-729	22	9	for	for	ADP
biomedich-729	22	10	healthcare	healthcare	NOUN
biomedich-729	22	11	has	have	AUX
biomedich-729	22	12	come	come	VERB
biomedich-729	22	13	with	with	ADP
biomedich-729	22	14	more	more	ADJ
biomedich-729	22	15	research	research	NOUN
biomedich-729	22	16	attention	attention	NOUN
biomedich-729	22	17	and	and	CCONJ
biomedich-729	22	18	warnings	warning	NOUN
biomedich-729	22	19	on	on	ADP
biomedich-729	22	20	the	the	DET
biomedich-729	22	21	safety	safety	NOUN
biomedich-729	22	22	of	of	ADP
biomedich-729	22	23	these	these	DET
biomedich-729	22	24	remedies	remedy	NOUN
biomedich-729	22	25	and	and	CCONJ
biomedich-729	22	26	their	their	PRON
biomedich-729	22	27	potential	potential	NOUN
biomedich-729	22	28	to	to	PART
biomedich-729	22	29	induce	induce	VERB
biomedich-729	22	30	adverse	adverse	ADJ
biomedich-729	22	31	reactions	reaction	NOUN
biomedich-729	22	32	(	(	PUNCT
biomedich-729	22	33	okaiyeto	okaiyeto	NOUN
biomedich-729	22	34	&	&	CCONJ
biomedich-729	22	35	oguntibeju	oguntibeju	NOUN
biomedich-729	22	36	,	,	PUNCT
biomedich-729	22	37	2021	2021	NUM
biomedich-729	22	38	:	:	PUNCT
biomedich-729	22	39	başaran	başaran	NOUN
biomedich-729	22	40	et	et	PROPN
biomedich-729	22	41	al	al	PROPN
biomedich-729	22	42	.	.	PROPN
biomedich-729	22	43	,	,	PUNCT
biomedich-729	22	44	2022	2022	NUM
biomedich-729	22	45	)	)	PUNCT
biomedich-729	22	46	.	.	PUNCT
biomedich-729	23	1	the	the	DET
biomedich-729	23	2	adverse	adverse	ADJ
biomedich-729	23	3	effects	effect	NOUN
biomedich-729	23	4	reported	report	VERB
biomedich-729	23	5	for	for	SCONJ
biomedich-729	23	6	some	some	DET
biomedich-729	23	7	plant	plant	NOUN
biomedich-729	23	8	extracts	extract	NOUN
biomedich-729	23	9	include	include	VERB
biomedich-729	23	10	,	,	PUNCT
biomedich-729	23	11	liver	liver	NOUN
biomedich-729	23	12	damage	damage	NOUN
biomedich-729	23	13	,	,	PUNCT
biomedich-729	23	14	injuries	injury	NOUN
biomedich-729	23	15	to	to	ADP
biomedich-729	23	16	tissues	tissue	NOUN
biomedich-729	23	17	of	of	ADP
biomedich-729	23	18	the	the	DET
biomedich-729	23	19	gastrointestinal	gastrointestinal	ADJ
biomedich-729	23	20	tract	tract	NOUN
biomedich-729	23	21	,	,	PUNCT
biomedich-729	23	22	kidney	kidney	NOUN
biomedich-729	23	23	failure	failure	NOUN
biomedich-729	23	24	,	,	PUNCT
biomedich-729	23	25	cerebral	cerebral	ADJ
biomedich-729	23	26	haemorrhage	haemorrhage	NOUN
biomedich-729	23	27	etc	etc	X
biomedich-729	23	28	.	.	X
biomedich-729	24	1	(	(	PUNCT
biomedich-729	24	2	posadzki	posadzki	NOUN
biomedich-729	24	3	et	et	PROPN
biomedich-729	24	4	al	al	PROPN
biomedich-729	24	5	.	.	PROPN
biomedich-729	24	6	,	,	PUNCT
biomedich-729	24	7	2013	2013	NUM
biomedich-729	24	8	;	;	PUNCT
biomedich-729	24	9	frenzel	frenzel	PROPN
biomedich-729	24	10	&	&	CCONJ
biomedich-729	24	11	teschke	teschke	ADJ
biomedich-729	24	12	,	,	PUNCT
biomedich-729	24	13	2016	2016	NUM
biomedich-729	24	14	)	)	PUNCT
biomedich-729	24	15	.	.	PUNCT
biomedich-729	25	1	extracts	extract	NOUN
biomedich-729	25	2	of	of	ADP
biomedich-729	25	3	cola	cola	NOUN
biomedich-729	25	4	species	specie	NOUN
biomedich-729	25	5	are	be	AUX
biomedich-729	25	6	used	use	VERB
biomedich-729	25	7	in	in	ADP
biomedich-729	25	8	traditional	traditional	ADJ
biomedich-729	25	9	medicine	medicine	NOUN
biomedich-729	25	10	for	for	ADP
biomedich-729	25	11	the	the	DET
biomedich-729	25	12	treatment	treatment	NOUN
biomedich-729	25	13	of	of	ADP
biomedich-729	25	14	various	various	ADJ
biomedich-729	25	15	diseases	disease	NOUN
biomedich-729	25	16	and	and	CCONJ
biomedich-729	25	17	ailments	ailment	NOUN
biomedich-729	25	18	,	,	PUNCT
biomedich-729	25	19	with	with	SCONJ
biomedich-729	25	20	some	some	PRON
biomedich-729	25	21	of	of	ADP
biomedich-729	25	22	them	they	PRON
biomedich-729	25	23	used	use	VERB
biomedich-729	25	24	in	in	ADP
biomedich-729	25	25	the	the	DET
biomedich-729	25	26	management	management	NOUN
biomedich-729	25	27	of	of	ADP
biomedich-729	25	28	diabetes	diabetes	NOUN
biomedich-729	25	29	and	and	CCONJ
biomedich-729	25	30	cancer	cancer	NOUN
biomedich-729	25	31	(	(	PUNCT
biomedich-729	25	32	ekalu	ekalu	PROPN
biomedich-729	25	33	&	&	CCONJ
biomedich-729	25	34	habila	habila	PROPN
biomedich-729	25	35	,	,	PUNCT
biomedich-729	25	36	2020	2020	NUM
biomedich-729	25	37	;	;	PUNCT
biomedich-729	25	38	ngoka	ngoka	NOUN
biomedich-729	25	39	et	et	PROPN
biomedich-729	25	40	al	al	PROPN
biomedich-729	25	41	,	,	PUNCT
biomedich-729	25	42	2021	2021	NUM
biomedich-729	25	43	)	)	PUNCT
biomedich-729	25	44	.	.	PUNCT
biomedich-729	26	1	cola	cola	PROPN
biomedich-729	26	2	rostrata	rostrata	PROPN
biomedich-729	26	3	is	be	AUX
biomedich-729	26	4	a	a	DET
biomedich-729	26	5	member	member	NOUN
biomedich-729	26	6	of	of	ADP
biomedich-729	26	7	the	the	DET
biomedich-729	26	8	genus	genus	NOUN
biomedich-729	26	9	that	that	PRON
biomedich-729	26	10	has	have	AUX
biomedich-729	26	11	limited	limit	VERB
biomedich-729	26	12	information	information	NOUN
biomedich-729	26	13	in	in	ADP
biomedich-729	26	14	the	the	DET
biomedich-729	26	15	literature	literature	NOUN
biomedich-729	26	16	on	on	ADP
biomedich-729	26	17	the	the	DET
biomedich-729	26	18	toxicity	toxicity	NOUN
biomedich-729	26	19	of	of	ADP
biomedich-729	26	20	its	its	PRON
biomedich-729	26	21	extracts	extract	NOUN
biomedich-729	26	22	.	.	PUNCT
biomedich-729	27	1	the	the	DET
biomedich-729	27	2	extract	extract	NOUN
biomedich-729	27	3	of	of	ADP
biomedich-729	27	4	the	the	DET
biomedich-729	27	5	root	root	NOUN
biomedich-729	27	6	bark	bark	NOUN
biomedich-729	27	7	of	of	ADP
biomedich-729	27	8	c.	c.	PROPN
biomedich-729	27	9	rostrata	rostrata	PROPN
biomedich-729	27	10	,	,	PUNCT
biomedich-729	27	11	which	which	PRON
biomedich-729	27	12	contains	contain	VERB
biomedich-729	27	13	flavonoids	flavonoid	NOUN
biomedich-729	27	14	,	,	PUNCT
biomedich-729	27	15	phenols	phenol	NOUN
biomedich-729	27	16	,	,	PUNCT
biomedich-729	27	17	steroids	steroid	NOUN
biomedich-729	27	18	,	,	PUNCT
biomedich-729	27	19	tannins	tannin	VERB
biomedich-729	27	20	saponins	saponin	NOUN
biomedich-729	27	21	,	,	PUNCT
biomedich-729	27	22	triterpenoids	triterpenoid	NOUN
biomedich-729	27	23	and	and	CCONJ
biomedich-729	27	24	alkaloids	alkaloid	NOUN
biomedich-729	27	25	was	be	AUX
biomedich-729	27	26	found	find	VERB
biomedich-729	27	27	to	to	PART
biomedich-729	27	28	be	be	AUX
biomedich-729	27	29	safe	safe	ADJ
biomedich-729	27	30	after	after	SCONJ
biomedich-729	27	31	the	the	DET
biomedich-729	27	32	acute	acute	NOUN
biomedich-729	27	33	toxicity	toxicity	NOUN
biomedich-729	27	34	of	of	ADP
biomedich-729	27	35	the	the	DET
biomedich-729	27	36	extract	extract	NOUN
biomedich-729	27	37	was	be	AUX
biomedich-729	27	38	assessed	assess	VERB
biomedich-729	27	39	in	in	ADP
biomedich-729	27	40	mice	mouse	NOUN
biomedich-729	27	41	(	(	PUNCT
biomedich-729	27	42	odion	odion	NOUN
biomedich-729	27	43	et	et	PROPN
biomedich-729	27	44	al	al	PROPN
biomedich-729	27	45	.	.	PROPN
biomedich-729	27	46	,	,	PUNCT
biomedich-729	27	47	2013	2013	NUM
biomedich-729	27	48	)	)	PUNCT
biomedich-729	27	49	.	.	PUNCT
biomedich-729	28	1	dongmo	dongmo	PROPN
biomedich-729	28	2	et	et	PROPN
biomedich-729	28	3	al	al	PROPN
biomedich-729	28	4	(	(	PUNCT
biomedich-729	28	5	2019	2019	NUM
biomedich-729	28	6	)	)	PUNCT
biomedich-729	28	7	found	find	VERB
biomedich-729	28	8	weak	weak	ADJ
biomedich-729	28	9	cytotoxic	cytotoxic	ADJ
biomedich-729	28	10	activity	activity	NOUN
biomedich-729	28	11	in	in	ADP
biomedich-729	28	12	the	the	DET
biomedich-729	28	13	prenylated	prenylate	VERB
biomedich-729	28	14	derivative	derivative	NOUN
biomedich-729	28	15	of	of	ADP
biomedich-729	28	16	compounds	compound	NOUN
biomedich-729	28	17	isolated	isolate	VERB
biomedich-729	28	18	from	from	ADP
biomedich-729	28	19	the	the	DET
biomedich-729	28	20	root	root	NOUN
biomedich-729	28	21	of	of	ADP
biomedich-729	28	22	c.	c.	PROPN
biomedich-729	28	23	rostrata	rostrata	PROPN
biomedich-729	28	24	against	against	ADP
biomedich-729	28	25	human	human	ADJ
biomedich-729	28	26	cervix	cervix	NOUN
biomedich-729	28	27	carcinoma	carcinoma	NOUN
biomedich-729	28	28	kb-3	kb-3	PROPN
biomedich-729	28	29	-	-	PUNCT
biomedich-729	28	30	1	1	NUM
biomedich-729	28	31	cells	cell	NOUN
biomedich-729	28	32	.	.	PUNCT
biomedich-729	29	1	ajayi	ajayi	NOUN
biomedich-729	29	2	et	et	PROPN
biomedich-729	29	3	al	al	PROPN
biomedich-729	29	4	(	(	PUNCT
biomedich-729	29	5	2022	2022	NUM
biomedich-729	29	6	,	,	PUNCT
biomedich-729	29	7	2023	2023	NUM
biomedich-729	29	8	)	)	PUNCT
biomedich-729	29	9	determined	determine	VERB
biomedich-729	29	10	the	the	DET
biomedich-729	29	11	components	component	NOUN
biomedich-729	29	12	of	of	ADP
biomedich-729	29	13	the	the	DET
biomedich-729	29	14	epicarp	epicarp	ADJ
biomedich-729	29	15	extract	extract	NOUN
biomedich-729	29	16	of	of	ADP
biomedich-729	29	17	c.	c.	PROPN
biomedich-729	29	18	rostrata	rostrata	PROPN
biomedich-729	29	19	and	and	CCONJ
biomedich-729	29	20	the	the	DET
biomedich-729	29	21	protein	protein	NOUN
biomedich-729	29	22	targets	target	NOUN
biomedich-729	29	23	of	of	ADP
biomedich-729	29	24	the	the	DET
biomedich-729	29	25	drug	drug	NOUN
biomedich-729	29	26	-	-	PUNCT
biomedich-729	29	27	like	like	ADJ
biomedich-729	29	28	compounds	compound	NOUN
biomedich-729	29	29	in	in	ADP
biomedich-729	29	30	it	it	PRON
biomedich-729	29	31	;	;	PUNCT
biomedich-729	29	32	they	they	PRON
biomedich-729	29	33	also	also	ADV
biomedich-729	29	34	found	find	VERB
biomedich-729	29	35	the	the	DET
biomedich-729	29	36	extract	extract	NOUN
biomedich-729	29	37	to	to	PART
biomedich-729	29	38	be	be	AUX
biomedich-729	29	39	significantly	significantly	ADV
biomedich-729	29	40	cytotoxic	cytotoxic	ADJ
biomedich-729	29	41	against	against	ADP
biomedich-729	29	42	mrc5	mrc5	NOUN
biomedich-729	29	43	-	-	PUNCT
biomedich-729	29	44	sv2	sv2	PROPN
biomedich-729	29	45	and	and	CCONJ
biomedich-729	29	46	hela	hela	ADJ
biomedich-729	29	47	cells	cell	NOUN
biomedich-729	29	48	with	with	ADP
biomedich-729	29	49	potential	potential	NOUN
biomedich-729	29	50	to	to	PART
biomedich-729	29	51	be	be	AUX
biomedich-729	29	52	effective	effective	ADJ
biomedich-729	29	53	against	against	ADP
biomedich-729	29	54	diabetes	diabetes	NOUN
biomedich-729	29	55	,	,	PUNCT
biomedich-729	29	56	pain	pain	NOUN
biomedich-729	29	57	manuscript	manuscript	NOUN
biomedich-729	29	58	received	receive	VERB
biomedich-729	29	59	:	:	PUNCT
biomedich-729	29	60	27	27	NUM
biomedich-729	29	61	february	february	NOUN
biomedich-729	29	62	,	,	PUNCT
biomedich-729	29	63	2025	2025	NUM
biomedich-729	29	64	.	.	PUNCT
biomedich-729	30	1	revision	revision	NOUN
biomedich-729	30	2	accepted	accept	VERB
biomedich-729	30	3	:	:	PUNCT
biomedich-729	30	4	20	20	NUM
biomedich-729	30	5	may	may	NOUN
biomedich-729	30	6	,	,	PUNCT
biomedich-729	30	7	2025	2025	NUM
biomedich-729	30	8	.	.	PUNCT
biomedich-729	31	1	published	publish	VERB
biomedich-729	31	2	:	:	PUNCT
biomedich-729	31	3	11	11	NUM
biomedich-729	31	4	july	july	NOUN
biomedich-729	31	5	,	,	PUNCT
biomedich-729	31	6	2025	2025	NUM
biomedich-729	31	7	.	.	PUNCT
biomedich-729	32	1	https://doi.org/10.14421/biomedich.2025.141.369-379	https://doi.org/10.14421/biomedich.2025.141.369-379	SYM
biomedich-729	32	2	370	370	NUM
biomedich-729	32	3	biology	biology	NOUN
biomedich-729	32	4	,	,	PUNCT
biomedich-729	32	5	medicine	medicine	NOUN
biomedich-729	32	6	,	,	PUNCT
biomedich-729	32	7	&	&	CCONJ
biomedich-729	32	8	natural	natural	ADJ
biomedich-729	32	9	product	product	NOUN
biomedich-729	32	10	chemistry	chemistry	NOUN
biomedich-729	32	11	14	14	NUM
biomedich-729	32	12	(	(	PUNCT
biomedich-729	32	13	1	1	NUM
biomedich-729	32	14	)	)	PUNCT
biomedich-729	32	15	,	,	PUNCT
biomedich-729	32	16	2025	2025	NUM
biomedich-729	32	17	:	:	PUNCT
biomedich-729	32	18	369	369	NUM
biomedich-729	32	19	-	-	SYM
biomedich-729	32	20	379	379	NUM
biomedich-729	32	21	and	and	CCONJ
biomedich-729	32	22	inflammatory	inflammatory	ADJ
biomedich-729	32	23	diseases	disease	NOUN
biomedich-729	32	24	.	.	PUNCT
biomedich-729	33	1	the	the	DET
biomedich-729	33	2	evaluation	evaluation	NOUN
biomedich-729	33	3	of	of	ADP
biomedich-729	33	4	absorption	absorption	NOUN
biomedich-729	33	5	,	,	PUNCT
biomedich-729	33	6	distribution	distribution	NOUN
biomedich-729	33	7	,	,	PUNCT
biomedich-729	33	8	metabolism	metabolism	NOUN
biomedich-729	33	9	,	,	PUNCT
biomedich-729	33	10	excretion	excretion	NOUN
biomedich-729	33	11	and	and	CCONJ
biomedich-729	33	12	toxicity	toxicity	NOUN
biomedich-729	33	13	(	(	PUNCT
biomedich-729	33	14	admet	admet	ADJ
biomedich-729	33	15	)	)	PUNCT
biomedich-729	33	16	profile	profile	NOUN
biomedich-729	33	17	of	of	ADP
biomedich-729	33	18	the	the	DET
biomedich-729	33	19	components	component	NOUN
biomedich-729	33	20	of	of	ADP
biomedich-729	33	21	the	the	DET
biomedich-729	33	22	crude	crude	ADJ
biomedich-729	33	23	extract	extract	NOUN
biomedich-729	33	24	of	of	ADP
biomedich-729	33	25	c.	c.	PROPN
biomedich-729	33	26	rostrata	rostrata	PROPN
biomedich-729	33	27	epicarp	epicarp	ADJ
biomedich-729	33	28	is	be	AUX
biomedich-729	33	29	yet	yet	ADV
biomedich-729	33	30	to	to	PART
biomedich-729	33	31	be	be	AUX
biomedich-729	33	32	done	do	VERB
biomedich-729	33	33	.	.	PUNCT
biomedich-729	34	1	generally	generally	ADV
biomedich-729	34	2	,	,	PUNCT
biomedich-729	34	3	the	the	DET
biomedich-729	34	4	toxicity	toxicity	NOUN
biomedich-729	34	5	of	of	ADP
biomedich-729	34	6	herbal	herbal	ADJ
biomedich-729	34	7	preparations	preparation	NOUN
biomedich-729	34	8	is	be	AUX
biomedich-729	34	9	a	a	DET
biomedich-729	34	10	function	function	NOUN
biomedich-729	34	11	of	of	ADP
biomedich-729	34	12	the	the	DET
biomedich-729	34	13	contributions	contribution	NOUN
biomedich-729	34	14	of	of	ADP
biomedich-729	34	15	each	each	PRON
biomedich-729	34	16	of	of	ADP
biomedich-729	34	17	the	the	DET
biomedich-729	34	18	molecules	molecule	NOUN
biomedich-729	34	19	in	in	ADP
biomedich-729	34	20	the	the	DET
biomedich-729	34	21	extracts	extract	NOUN
biomedich-729	34	22	.	.	PUNCT
biomedich-729	35	1	the	the	DET
biomedich-729	35	2	interactions	interaction	NOUN
biomedich-729	35	3	among	among	ADP
biomedich-729	35	4	extract	extract	NOUN
biomedich-729	35	5	components	component	NOUN
biomedich-729	35	6	could	could	AUX
biomedich-729	35	7	result	result	VERB
biomedich-729	35	8	in	in	ADP
biomedich-729	35	9	the	the	DET
biomedich-729	35	10	elimination	elimination	NOUN
biomedich-729	35	11	of	of	ADP
biomedich-729	35	12	the	the	DET
biomedich-729	35	13	effect	effect	NOUN
biomedich-729	35	14	of	of	ADP
biomedich-729	35	15	some	some	DET
biomedich-729	35	16	potentially	potentially	ADV
biomedich-729	35	17	harmful	harmful	ADJ
biomedich-729	35	18	components	component	NOUN
biomedich-729	35	19	or	or	CCONJ
biomedich-729	35	20	accentuation	accentuation	NOUN
biomedich-729	35	21	of	of	ADP
biomedich-729	35	22	the	the	DET
biomedich-729	35	23	toxic	toxic	ADJ
biomedich-729	35	24	effect	effect	NOUN
biomedich-729	35	25	of	of	ADP
biomedich-729	35	26	the	the	DET
biomedich-729	35	27	few	few	ADJ
biomedich-729	35	28	potentially	potentially	ADV
biomedich-729	35	29	harmful	harmful	ADJ
biomedich-729	35	30	components	component	NOUN
biomedich-729	35	31	.	.	PUNCT
biomedich-729	36	1	reports	report	NOUN
biomedich-729	36	2	show	show	VERB
biomedich-729	36	3	that	that	SCONJ
biomedich-729	36	4	in	in	ADP
biomedich-729	36	5	some	some	DET
biomedich-729	36	6	cases	case	NOUN
biomedich-729	36	7	,	,	PUNCT
biomedich-729	36	8	the	the	DET
biomedich-729	36	9	direct	direct	ADJ
biomedich-729	36	10	interactions	interaction	NOUN
biomedich-729	36	11	of	of	ADP
biomedich-729	36	12	extract	extract	NOUN
biomedich-729	36	13	components	component	NOUN
biomedich-729	36	14	could	could	AUX
biomedich-729	36	15	be	be	AUX
biomedich-729	36	16	synergistic	synergistic	ADJ
biomedich-729	36	17	,	,	PUNCT
biomedich-729	36	18	antagonistic	antagonistic	ADJ
biomedich-729	36	19	or	or	CCONJ
biomedich-729	36	20	additive	additive	ADJ
biomedich-729	36	21	in	in	ADP
biomedich-729	36	22	nature	nature	NOUN
biomedich-729	36	23	to	to	PART
biomedich-729	36	24	bring	bring	VERB
biomedich-729	36	25	about	about	ADP
biomedich-729	36	26	the	the	DET
biomedich-729	36	27	observed	observed	ADJ
biomedich-729	36	28	pharmacological	pharmacological	ADJ
biomedich-729	36	29	response	response	NOUN
biomedich-729	36	30	in	in	ADP
biomedich-729	36	31	living	living	NOUN
biomedich-729	36	32	systems	system	NOUN
biomedich-729	36	33	,	,	PUNCT
biomedich-729	36	34	while	while	SCONJ
biomedich-729	36	35	in	in	ADP
biomedich-729	36	36	some	some	DET
biomedich-729	36	37	other	other	ADJ
biomedich-729	36	38	cases	case	NOUN
biomedich-729	36	39	,	,	PUNCT
biomedich-729	36	40	there	there	PRON
biomedich-729	36	41	is	be	VERB
biomedich-729	36	42	indirect	indirect	ADJ
biomedich-729	36	43	interaction	interaction	NOUN
biomedich-729	36	44	,	,	PUNCT
biomedich-729	36	45	products	product	NOUN
biomedich-729	36	46	of	of	ADP
biomedich-729	36	47	the	the	DET
biomedich-729	36	48	metabolism	metabolism	NOUN
biomedich-729	36	49	of	of	ADP
biomedich-729	36	50	the	the	DET
biomedich-729	36	51	constituent	constituent	NOUN
biomedich-729	36	52	of	of	ADP
biomedich-729	36	53	the	the	DET
biomedich-729	36	54	extracts	extract	NOUN
biomedich-729	36	55	may	may	AUX
biomedich-729	36	56	interact	interact	VERB
biomedich-729	36	57	with	with	ADP
biomedich-729	36	58	one	one	NUM
biomedich-729	36	59	another	another	DET
biomedich-729	36	60	to	to	PART
biomedich-729	36	61	produce	produce	VERB
biomedich-729	36	62	the	the	DET
biomedich-729	36	63	observed	observed	ADJ
biomedich-729	36	64	effect	effect	NOUN
biomedich-729	36	65	(	(	PUNCT
biomedich-729	36	66	matotoka	matotoka	PROPN
biomedich-729	36	67	&	&	CCONJ
biomedich-729	36	68	masoko	masoko	PROPN
biomedich-729	36	69	,	,	PUNCT
biomedich-729	36	70	2018	2018	NUM
biomedich-729	36	71	;	;	PUNCT
biomedich-729	36	72	uduwana	uduwana	PROPN
biomedich-729	36	73	et	et	PROPN
biomedich-729	36	74	al	al	PROPN
biomedich-729	36	75	.	.	PROPN
biomedich-729	36	76	,	,	PUNCT
biomedich-729	36	77	2023	2023	NUM
biomedich-729	36	78	)	)	PUNCT
biomedich-729	36	79	.	.	PUNCT
biomedich-729	37	1	to	to	PART
biomedich-729	37	2	assess	assess	VERB
biomedich-729	37	3	the	the	DET
biomedich-729	37	4	safety	safety	NOUN
biomedich-729	37	5	and	and	CCONJ
biomedich-729	37	6	mechanisms	mechanism	NOUN
biomedich-729	37	7	of	of	ADP
biomedich-729	37	8	pharmacological	pharmacological	ADJ
biomedich-729	37	9	activities	activity	NOUN
biomedich-729	37	10	of	of	ADP
biomedich-729	37	11	the	the	DET
biomedich-729	37	12	crude	crude	ADJ
biomedich-729	37	13	extract	extract	NOUN
biomedich-729	37	14	of	of	ADP
biomedich-729	37	15	c.	c.	PROPN
biomedich-729	37	16	rostrata	rostrata	PROPN
biomedich-729	37	17	epicarp	epicarp	ADJ
biomedich-729	37	18	as	as	ADP
biomedich-729	37	19	a	a	DET
biomedich-729	37	20	remedy	remedy	NOUN
biomedich-729	37	21	for	for	ADP
biomedich-729	37	22	potential	potential	ADJ
biomedich-729	37	23	use	use	NOUN
biomedich-729	37	24	in	in	ADP
biomedich-729	37	25	traditional	traditional	ADJ
biomedich-729	37	26	medicine	medicine	NOUN
biomedich-729	37	27	against	against	ADP
biomedich-729	37	28	diabetes	diabetes	NOUN
biomedich-729	37	29	,	,	PUNCT
biomedich-729	37	30	inflammatory	inflammatory	ADJ
biomedich-729	37	31	diseases	disease	NOUN
biomedich-729	37	32	,	,	PUNCT
biomedich-729	37	33	pain	pain	NOUN
biomedich-729	37	34	and	and	CCONJ
biomedich-729	37	35	cancer	cancer	NOUN
biomedich-729	37	36	,	,	PUNCT
biomedich-729	37	37	this	this	DET
biomedich-729	37	38	study	study	NOUN
biomedich-729	37	39	evaluated	evaluate	VERB
biomedich-729	37	40	the	the	DET
biomedich-729	37	41	metabolism	metabolism	NOUN
biomedich-729	37	42	,	,	PUNCT
biomedich-729	37	43	excretion	excretion	NOUN
biomedich-729	37	44	,	,	PUNCT
biomedich-729	37	45	toxicological	toxicological	ADJ
biomedich-729	37	46	properties	property	NOUN
biomedich-729	37	47	,	,	PUNCT
biomedich-729	37	48	mode	mode	NOUN
biomedich-729	37	49	of	of	ADP
biomedich-729	37	50	action	action	NOUN
biomedich-729	37	51	,	,	PUNCT
biomedich-729	37	52	and	and	CCONJ
biomedich-729	37	53	binding	bind	VERB
biomedich-729	37	54	affinities	affinity	NOUN
biomedich-729	37	55	of	of	ADP
biomedich-729	37	56	the	the	DET
biomedich-729	37	57	compounds	compound	NOUN
biomedich-729	37	58	present	present	ADJ
biomedich-729	37	59	in	in	ADP
biomedich-729	37	60	ethanol	ethanol	NOUN
biomedich-729	37	61	extract	extract	NOUN
biomedich-729	37	62	of	of	ADP
biomedich-729	37	63	the	the	DET
biomedich-729	37	64	plant	plant	NOUN
biomedich-729	37	65	using	use	VERB
biomedich-729	37	66	in	in	ADP
biomedich-729	37	67	silico	silico	NOUN
biomedich-729	37	68	analyses	analysis	NOUN
biomedich-729	37	69	and	and	CCONJ
biomedich-729	37	70	molecular	molecular	ADJ
biomedich-729	37	71	docking	docking	NOUN
biomedich-729	37	72	.	.	PUNCT
biomedich-729	38	1	molecular	molecular	ADJ
biomedich-729	38	2	docking	docking	NOUN
biomedich-729	38	3	of	of	ADP
biomedich-729	38	4	most	most	ADJ
biomedich-729	38	5	toxic	toxic	ADJ
biomedich-729	38	6	components	component	NOUN
biomedich-729	38	7	of	of	ADP
biomedich-729	38	8	the	the	DET
biomedich-729	38	9	extract	extract	NOUN
biomedich-729	38	10	was	be	AUX
biomedich-729	38	11	carried	carry	VERB
biomedich-729	38	12	out	out	ADP
biomedich-729	38	13	against	against	ADP
biomedich-729	38	14	selected	select	VERB
biomedich-729	38	15	proteins	protein	NOUN
biomedich-729	38	16	in	in	ADP
biomedich-729	38	17	the	the	DET
biomedich-729	38	18	pathways	pathway	NOUN
biomedich-729	38	19	perturbed	perturb	VERB
biomedich-729	38	20	by	by	ADP
biomedich-729	38	21	the	the	DET
biomedich-729	38	22	extract	extract	NOUN
biomedich-729	38	23	fractions	fraction	NOUN
biomedich-729	38	24	.	.	PUNCT
biomedich-729	39	1	materials	material	NOUN
biomedich-729	39	2	and	and	CCONJ
biomedich-729	39	3	methods	method	NOUN
biomedich-729	39	4	extract	extract	VERB
biomedich-729	39	5	preparation	preparation	NOUN
biomedich-729	39	6	,	,	PUNCT
biomedich-729	39	7	fractionation	fractionation	NOUN
biomedich-729	39	8	and	and	CCONJ
biomedich-729	39	9	gas	gas	NOUN
biomedich-729	39	10	chromatography	chromatography	NOUN
biomedich-729	39	11	-	-	PUNCT
biomedich-729	39	12	mass	mass	NOUN
biomedich-729	39	13	spectroscopy	spectroscopy	NOUN
biomedich-729	39	14	(	(	PUNCT
biomedich-729	39	15	gc	gc	PROPN
biomedich-729	39	16	-	-	PUNCT
biomedich-729	39	17	ms	ms	NOUN
biomedich-729	39	18	)	)	PUNCT
biomedich-729	39	19	analysis	analysis	NOUN
biomedich-729	39	20	the	the	DET
biomedich-729	39	21	collection	collection	NOUN
biomedich-729	39	22	of	of	ADP
biomedich-729	39	23	plant	plant	NOUN
biomedich-729	39	24	materials	material	NOUN
biomedich-729	39	25	,	,	PUNCT
biomedich-729	39	26	extract	extract	VERB
biomedich-729	39	27	preparation	preparation	NOUN
biomedich-729	39	28	,	,	PUNCT
biomedich-729	39	29	and	and	CCONJ
biomedich-729	39	30	gc	gc	AUX
biomedich-729	39	31	-	-	PUNCT
biomedich-729	39	32	ms	ms	NOUN
biomedich-729	39	33	analysis	analysis	NOUN
biomedich-729	39	34	of	of	ADP
biomedich-729	39	35	the	the	DET
biomedich-729	39	36	extract	extract	NOUN
biomedich-729	39	37	have	have	AUX
biomedich-729	39	38	been	be	AUX
biomedich-729	39	39	previously	previously	ADV
biomedich-729	39	40	reported	report	VERB
biomedich-729	39	41	by	by	ADP
biomedich-729	39	42	ajayi	ajayi	NOUN
biomedich-729	39	43	et	et	NOUN
biomedich-729	39	44	al	al	PROPN
biomedich-729	39	45	(	(	PUNCT
biomedich-729	39	46	2022	2022	NUM
biomedich-729	39	47	)	)	PUNCT
biomedich-729	39	48	.	.	PUNCT
biomedich-729	40	1	briefly	briefly	ADV
biomedich-729	40	2	,	,	PUNCT
biomedich-729	40	3	the	the	DET
biomedich-729	40	4	epicarp	epicarp	NOUN
biomedich-729	40	5	of	of	ADP
biomedich-729	40	6	fresh	fresh	ADJ
biomedich-729	40	7	ripe	ripe	ADJ
biomedich-729	40	8	c.	c.	NOUN
biomedich-729	40	9	rostrata	rostrata	NOUN
biomedich-729	40	10	fruit	fruit	NOUN
biomedich-729	40	11	was	be	AUX
biomedich-729	40	12	collected	collect	VERB
biomedich-729	40	13	,	,	PUNCT
biomedich-729	40	14	cut	cut	VERB
biomedich-729	40	15	into	into	ADP
biomedich-729	40	16	small	small	ADJ
biomedich-729	40	17	pieces	piece	NOUN
biomedich-729	40	18	,	,	PUNCT
biomedich-729	40	19	air	air	NOUN
biomedich-729	40	20	-	-	PUNCT
biomedich-729	40	21	dried	dry	VERB
biomedich-729	40	22	at	at	ADP
biomedich-729	40	23	room	room	NOUN
biomedich-729	40	24	temperature	temperature	NOUN
biomedich-729	40	25	under	under	ADP
biomedich-729	40	26	shade	shade	NOUN
biomedich-729	40	27	for	for	ADP
biomedich-729	40	28	four	four	NUM
biomedich-729	40	29	months	month	NOUN
biomedich-729	40	30	,	,	PUNCT
biomedich-729	40	31	and	and	CCONJ
biomedich-729	40	32	pulverized	pulverize	VERB
biomedich-729	40	33	with	with	ADP
biomedich-729	40	34	an	an	DET
biomedich-729	40	35	electric	electric	ADJ
biomedich-729	40	36	blender	blender	NOUN
biomedich-729	40	37	.	.	PUNCT
biomedich-729	41	1	the	the	DET
biomedich-729	41	2	pulverized	pulverize	VERB
biomedich-729	41	3	material	material	NOUN
biomedich-729	41	4	was	be	AUX
biomedich-729	41	5	soaked	soak	VERB
biomedich-729	41	6	in	in	ADP
biomedich-729	41	7	absolute	absolute	ADJ
biomedich-729	41	8	ethanol	ethanol	NOUN
biomedich-729	41	9	for	for	ADP
biomedich-729	41	10	six	six	NUM
biomedich-729	41	11	days	day	NOUN
biomedich-729	41	12	with	with	ADP
biomedich-729	41	13	frequent	frequent	ADJ
biomedich-729	41	14	rigorous	rigorous	ADJ
biomedich-729	41	15	shaking	shaking	NOUN
biomedich-729	41	16	of	of	ADP
biomedich-729	41	17	the	the	DET
biomedich-729	41	18	extraction	extraction	NOUN
biomedich-729	41	19	vessel	vessel	NOUN
biomedich-729	41	20	to	to	PART
biomedich-729	41	21	disperse	disperse	VERB
biomedich-729	41	22	phytochemicals	phytochemical	NOUN
biomedich-729	41	23	.	.	PUNCT
biomedich-729	42	1	the	the	DET
biomedich-729	42	2	crude	crude	ADJ
biomedich-729	42	3	extract	extract	NOUN
biomedich-729	42	4	was	be	AUX
biomedich-729	42	5	obtained	obtain	VERB
biomedich-729	42	6	by	by	ADP
biomedich-729	42	7	filtration	filtration	NOUN
biomedich-729	42	8	,	,	PUNCT
biomedich-729	42	9	followed	follow	VERB
biomedich-729	42	10	by	by	ADP
biomedich-729	42	11	concentration	concentration	NOUN
biomedich-729	42	12	under	under	ADP
biomedich-729	42	13	pressure	pressure	NOUN
biomedich-729	42	14	,	,	PUNCT
biomedich-729	42	15	and	and	CCONJ
biomedich-729	42	16	then	then	ADV
biomedich-729	42	17	air	air	NOUN
biomedich-729	42	18	-	-	PUNCT
biomedich-729	42	19	drying	dry	VERB
biomedich-729	42	20	.	.	PUNCT
biomedich-729	43	1	the	the	DET
biomedich-729	43	2	air	air	NOUN
biomedich-729	43	3	-	-	PUNCT
biomedich-729	43	4	dried	dry	VERB
biomedich-729	43	5	crude	crude	ADJ
biomedich-729	43	6	extract	extract	NOUN
biomedich-729	43	7	was	be	AUX
biomedich-729	43	8	fractionated	fractionate	VERB
biomedich-729	43	9	via	via	ADP
biomedich-729	43	10	liquid	liquid	NOUN
biomedich-729	43	11	-	-	PUNCT
biomedich-729	43	12	liquid	liquid	NOUN
biomedich-729	43	13	partitioning	partitioning	NOUN
biomedich-729	43	14	with	with	ADP
biomedich-729	43	15	70	70	NUM
biomedich-729	43	16	%	%	NOUN
biomedich-729	43	17	methanol	methanol	NOUN
biomedich-729	43	18	solution	solution	NOUN
biomedich-729	43	19	and	and	CCONJ
biomedich-729	43	20	n	n	CCONJ
biomedich-729	43	21	-	-	PUNCT
biomedich-729	43	22	hexane	hexane	NOUN
biomedich-729	43	23	to	to	PART
biomedich-729	43	24	obtain	obtain	VERB
biomedich-729	43	25	a	a	DET
biomedich-729	43	26	polar	polar	ADJ
biomedich-729	43	27	fraction	fraction	NOUN
biomedich-729	43	28	and	and	CCONJ
biomedich-729	43	29	a	a	DET
biomedich-729	43	30	non	non	ADJ
biomedich-729	43	31	-	-	ADJ
biomedich-729	43	32	polar	polar	ADJ
biomedich-729	43	33	fraction	fraction	NOUN
biomedich-729	43	34	.	.	PUNCT
biomedich-729	44	1	the	the	DET
biomedich-729	44	2	constituents	constituent	NOUN
biomedich-729	44	3	of	of	ADP
biomedich-729	44	4	the	the	DET
biomedich-729	44	5	fractions	fraction	NOUN
biomedich-729	44	6	were	be	AUX
biomedich-729	44	7	identified	identify	VERB
biomedich-729	44	8	via	via	ADP
biomedich-729	44	9	gc	gc	PROPN
biomedich-729	44	10	-	-	PUNCT
biomedich-729	44	11	ms	ms	PROPN
biomedich-729	44	12	,	,	PUNCT
biomedich-729	44	13	the	the	DET
biomedich-729	44	14	identified	identify	VERB
biomedich-729	44	15	compounds	compound	NOUN
biomedich-729	44	16	were	be	AUX
biomedich-729	44	17	reported	report	VERB
biomedich-729	44	18	by	by	ADP
biomedich-729	44	19	ajayi	ajayi	NOUN
biomedich-729	44	20	et	et	PROPN
biomedich-729	44	21	al	al	PROPN
biomedich-729	44	22	(	(	PUNCT
biomedich-729	44	23	2022	2022	NUM
biomedich-729	44	24	)	)	PUNCT
biomedich-729	44	25	.	.	PUNCT
biomedich-729	45	1	in	in	ADP
biomedich-729	45	2	silico	silico	NOUN
biomedich-729	45	3	metabolism	metabolism	NOUN
biomedich-729	45	4	,	,	PUNCT
biomedich-729	45	5	excretion	excretion	NOUN
biomedich-729	45	6	and	and	CCONJ
biomedich-729	45	7	toxicity	toxicity	NOUN
biomedich-729	45	8	analyses	analysis	NOUN
biomedich-729	45	9	of	of	ADP
biomedich-729	45	10	the	the	DET
biomedich-729	45	11	components	component	NOUN
biomedich-729	45	12	of	of	ADP
biomedich-729	45	13	extract	extract	NOUN
biomedich-729	45	14	fractions	fraction	NOUN
biomedich-729	45	15	the	the	DET
biomedich-729	45	16	simplified	simplified	ADJ
biomedich-729	45	17	molecular	molecular	ADJ
biomedich-729	45	18	input	input	NOUN
biomedich-729	45	19	line	line	NOUN
biomedich-729	45	20	entry	entry	NOUN
biomedich-729	45	21	system	system	NOUN
biomedich-729	45	22	(	(	PUNCT
biomedich-729	45	23	smiles	smile	NOUN
biomedich-729	45	24	)	)	PUNCT
biomedich-729	45	25	notation	notation	NOUN
biomedich-729	45	26	for	for	ADP
biomedich-729	45	27	each	each	DET
biomedich-729	45	28	compound	compound	NOUN
biomedich-729	45	29	present	present	ADJ
biomedich-729	45	30	in	in	ADP
biomedich-729	45	31	the	the	DET
biomedich-729	45	32	two	two	NUM
biomedich-729	45	33	extract	extract	NOUN
biomedich-729	45	34	fractions	fraction	NOUN
biomedich-729	45	35	was	be	AUX
biomedich-729	45	36	obtained	obtain	VERB
biomedich-729	45	37	from	from	ADP
biomedich-729	45	38	pubchem	pubchem	NOUN
biomedich-729	45	39	.	.	PUNCT
biomedich-729	46	1	the	the	DET
biomedich-729	46	2	smiles	smile	NOUN
biomedich-729	46	3	were	be	AUX
biomedich-729	46	4	submitted	submit	VERB
biomedich-729	46	5	to	to	PART
biomedich-729	46	6	admetlab	admetlab	VERB
biomedich-729	46	7	2.0	2.0	NUM
biomedich-729	46	8	online	online	ADJ
biomedich-729	46	9	platform	platform	NOUN
biomedich-729	46	10	for	for	ADP
biomedich-729	46	11	systematic	systematic	ADJ
biomedich-729	46	12	evaluation	evaluation	NOUN
biomedich-729	46	13	of	of	ADP
biomedich-729	46	14	the	the	DET
biomedich-729	46	15	metabolism	metabolism	NOUN
biomedich-729	46	16	,	,	PUNCT
biomedich-729	46	17	excretion	excretion	NOUN
biomedich-729	46	18	and	and	CCONJ
biomedich-729	46	19	toxicity	toxicity	NOUN
biomedich-729	46	20	properties	property	NOUN
biomedich-729	46	21	of	of	ADP
biomedich-729	46	22	each	each	DET
biomedich-729	46	23	constituent	constituent	NOUN
biomedich-729	46	24	of	of	ADP
biomedich-729	46	25	the	the	DET
biomedich-729	46	26	extract	extract	NOUN
biomedich-729	46	27	fractions	fraction	NOUN
biomedich-729	46	28	.	.	PUNCT
biomedich-729	47	1	for	for	ADP
biomedich-729	47	2	each	each	DET
biomedich-729	47	3	constituent	constituent	NOUN
biomedich-729	47	4	of	of	ADP
biomedich-729	47	5	the	the	DET
biomedich-729	47	6	extract	extract	NOUN
biomedich-729	47	7	fractions	fraction	NOUN
biomedich-729	47	8	,	,	PUNCT
biomedich-729	47	9	the	the	DET
biomedich-729	47	10	probabilities	probability	NOUN
biomedich-729	47	11	of	of	ADP
biomedich-729	47	12	having	have	VERB
biomedich-729	47	13	specific	specific	ADJ
biomedich-729	47	14	properties	property	NOUN
biomedich-729	47	15	that	that	PRON
biomedich-729	47	16	are	be	AUX
biomedich-729	47	17	known	know	VERB
biomedich-729	47	18	to	to	PART
biomedich-729	47	19	define	define	VERB
biomedich-729	47	20	the	the	DET
biomedich-729	47	21	toxicity	toxicity	NOUN
biomedich-729	47	22	of	of	ADP
biomedich-729	47	23	known	know	VERB
biomedich-729	47	24	drug	drug	NOUN
biomedich-729	47	25	compounds	compound	NOUN
biomedich-729	47	26	were	be	AUX
biomedich-729	47	27	scored	score	VERB
biomedich-729	47	28	;	;	PUNCT
biomedich-729	47	29	these	these	DET
biomedich-729	47	30	properties	property	NOUN
biomedich-729	47	31	include	include	VERB
biomedich-729	47	32	,	,	PUNCT
biomedich-729	47	33	permeation	permeation	NOUN
biomedich-729	47	34	of	of	ADP
biomedich-729	47	35	the	the	DET
biomedich-729	47	36	blood	blood	NOUN
biomedich-729	47	37	-	-	PUNCT
biomedich-729	47	38	brain	brain	NOUN
biomedich-729	47	39	barrier	barrier	NOUN
biomedich-729	47	40	,	,	PUNCT
biomedich-729	47	41	clearance	clearance	NOUN
biomedich-729	47	42	(	(	PUNCT
biomedich-729	47	43	excretion	excretion	NOUN
biomedich-729	47	44	)	)	PUNCT
biomedich-729	47	45	,	,	PUNCT
biomedich-729	47	46	carcinogenicity	carcinogenicity	NOUN
biomedich-729	47	47	,	,	PUNCT
biomedich-729	47	48	inhibition	inhibition	NOUN
biomedich-729	47	49	of	of	ADP
biomedich-729	47	50	members	member	NOUN
biomedich-729	47	51	of	of	ADP
biomedich-729	47	52	cytochrome	cytochrome	NOUN
biomedich-729	47	53	families	family	NOUN
biomedich-729	47	54	,	,	PUNCT
biomedich-729	47	55	induction	induction	NOUN
biomedich-729	47	56	of	of	ADP
biomedich-729	47	57	liver	liver	NOUN
biomedich-729	47	58	injury	injury	NOUN
biomedich-729	47	59	,	,	PUNCT
biomedich-729	47	60	and	and	CCONJ
biomedich-729	47	61	inhibition	inhibition	NOUN
biomedich-729	47	62	of	of	ADP
biomedich-729	47	63	tox21	tox21	PROPN
biomedich-729	47	64	pathway	pathway	NOUN
biomedich-729	47	65	proteins	protein	NOUN
biomedich-729	47	66	.	.	PUNCT
biomedich-729	48	1	the	the	DET
biomedich-729	48	2	probabilities	probability	NOUN
biomedich-729	48	3	of	of	ADP
biomedich-729	48	4	the	the	DET
biomedich-729	48	5	constituents	constituent	NOUN
biomedich-729	48	6	binding	bind	VERB
biomedich-729	48	7	to	to	ADP
biomedich-729	48	8	these	these	DET
biomedich-729	48	9	proteins	protein	NOUN
biomedich-729	48	10	and	and	CCONJ
biomedich-729	48	11	inhibiting	inhibit	VERB
biomedich-729	48	12	their	their	PRON
biomedich-729	48	13	actions	action	NOUN
biomedich-729	48	14	(	(	PUNCT
biomedich-729	48	15	or	or	CCONJ
biomedich-729	48	16	inducing	induce	VERB
biomedich-729	48	17	toxic	toxic	ADJ
biomedich-729	48	18	responses	response	NOUN
biomedich-729	48	19	)	)	PUNCT
biomedich-729	48	20	were	be	AUX
biomedich-729	48	21	reported	report	VERB
biomedich-729	48	22	as	as	SCONJ
biomedich-729	48	23	follows	follow	VERB
biomedich-729	48	24	:	:	PUNCT
biomedich-729	48	25	probability	probability	NOUN
biomedich-729	48	26	0.0–0.1	0.0–0.1	NOUN
biomedich-729	48	27	as	as	ADP
biomedich-729	48	28	no	no	DET
biomedich-729	48	29	binding	binding	ADJ
biomedich-729	48	30	,	,	PUNCT
biomedich-729	48	31	0.1–0.3	0.1–0.3	PUNCT
biomedich-729	49	1	as	as	ADP
biomedich-729	49	2	very	very	ADV
biomedich-729	49	3	low	low	ADJ
biomedich-729	49	4	inhibition	inhibition	NOUN
biomedich-729	49	5	potential	potential	NOUN
biomedich-729	49	6	,	,	PUNCT
biomedich-729	49	7	0.3–0.5	0.3–0.5	PUNCT
biomedich-729	49	8	as	as	ADP
biomedich-729	49	9	low	low	ADJ
biomedich-729	49	10	inhibition	inhibition	NOUN
biomedich-729	49	11	potential	potential	NOUN
biomedich-729	49	12	,	,	PUNCT
biomedich-729	49	13	0.5–0.7	0.5–0.7	ADP
biomedich-729	49	14	as	as	ADP
biomedich-729	49	15	medium	medium	ADJ
biomedich-729	49	16	inhibition	inhibition	NOUN
biomedich-729	49	17	potential	potential	NOUN
biomedich-729	49	18	,	,	PUNCT
biomedich-729	49	19	0.7–0.9	0.7–0.9	X
biomedich-729	49	20	high	high	ADJ
biomedich-729	49	21	inhibition	inhibition	NOUN
biomedich-729	49	22	potential	potential	NOUN
biomedich-729	49	23	and	and	CCONJ
biomedich-729	49	24	0.9–1.0	0.9–1.0	NOUN
biomedich-729	49	25	as	as	ADP
biomedich-729	49	26	having	have	VERB
biomedich-729	49	27	very	very	ADV
biomedich-729	49	28	high	high	ADJ
biomedich-729	49	29	inhibition	inhibition	NOUN
biomedich-729	49	30	potential	potential	NOUN
biomedich-729	49	31	;	;	PUNCT
biomedich-729	49	32	with	with	ADP
biomedich-729	49	33	the	the	DET
biomedich-729	49	34	very	very	ADV
biomedich-729	49	35	high	high	ADJ
biomedich-729	49	36	inhibition	inhibition	NOUN
biomedich-729	49	37	potential	potential	NOUN
biomedich-729	49	38	corresponding	correspond	VERB
biomedich-729	49	39	to	to	ADP
biomedich-729	49	40	the	the	DET
biomedich-729	49	41	most	most	ADV
biomedich-729	49	42	profound	profound	ADJ
biomedich-729	49	43	toxic	toxic	ADJ
biomedich-729	49	44	effect	effect	NOUN
biomedich-729	49	45	.	.	PUNCT
biomedich-729	50	1	molecular	molecular	ADJ
biomedich-729	50	2	docking	docking	NOUN
biomedich-729	50	3	based	base	VERB
biomedich-729	50	4	on	on	ADP
biomedich-729	50	5	the	the	DET
biomedich-729	50	6	toxicity	toxicity	NOUN
biomedich-729	50	7	potential	potential	NOUN
biomedich-729	50	8	of	of	ADP
biomedich-729	50	9	the	the	DET
biomedich-729	50	10	extract	extract	NOUN
biomedich-729	50	11	constituents	constituent	NOUN
biomedich-729	50	12	,	,	PUNCT
biomedich-729	50	13	the	the	DET
biomedich-729	50	14	most	most	ADV
biomedich-729	50	15	toxic	toxic	ADJ
biomedich-729	50	16	components	component	NOUN
biomedich-729	50	17	were	be	AUX
biomedich-729	50	18	identified	identify	VERB
biomedich-729	50	19	via	via	ADP
biomedich-729	50	20	crosstabulation	crosstabulation	NOUN
biomedich-729	50	21	of	of	ADP
biomedich-729	50	22	the	the	DET
biomedich-729	50	23	scores	score	NOUN
biomedich-729	50	24	of	of	ADP
biomedich-729	50	25	their	their	PRON
biomedich-729	50	26	toxicity	toxicity	NOUN
biomedich-729	50	27	properties	property	NOUN
biomedich-729	50	28	.	.	PUNCT
biomedich-729	51	1	the	the	DET
biomedich-729	51	2	identified	identify	VERB
biomedich-729	51	3	compounds	compound	NOUN
biomedich-729	51	4	were	be	AUX
biomedich-729	51	5	docked	dock	VERB
biomedich-729	51	6	against	against	ADP
biomedich-729	51	7	cyp1a2	cyp1a2	PROPN
biomedich-729	51	8	,	,	PUNCT
biomedich-729	51	9	cyp2c19	cyp2c19	PROPN
biomedich-729	51	10	,	,	PUNCT
biomedich-729	51	11	na+/k+–atpase	na+/k+–atpase	PROPN
biomedich-729	51	12	,	,	PUNCT
biomedich-729	51	13	and	and	CCONJ
biomedich-729	51	14	nadh	nadh	NOUN
biomedich-729	51	15	dehydrogenase	dehydrogenase	NOUN
biomedich-729	51	16	1	1	NUM
biomedich-729	52	1	.	.	X
biomedich-729	52	2	cytochrome	cytochrome	NOUN
biomedich-729	52	3	p450	p450	PROPN
biomedich-729	52	4	members	member	NOUN
biomedich-729	52	5	are	be	AUX
biomedich-729	52	6	important	important	ADJ
biomedich-729	52	7	in	in	ADP
biomedich-729	52	8	the	the	DET
biomedich-729	52	9	metabolism	metabolism	NOUN
biomedich-729	52	10	of	of	ADP
biomedich-729	52	11	xenobiotics	xenobiotic	NOUN
biomedich-729	52	12	,	,	PUNCT
biomedich-729	52	13	their	their	PRON
biomedich-729	52	14	impairment	impairment	NOUN
biomedich-729	52	15	have	have	AUX
biomedich-729	52	16	been	be	AUX
biomedich-729	52	17	reported	report	VERB
biomedich-729	52	18	to	to	PART
biomedich-729	52	19	have	have	VERB
biomedich-729	52	20	profound	profound	ADJ
biomedich-729	52	21	toxicological	toxicological	ADJ
biomedich-729	52	22	implications	implication	NOUN
biomedich-729	52	23	in	in	ADP
biomedich-729	52	24	human	human	ADJ
biomedich-729	52	25	cells	cell	NOUN
biomedich-729	52	26	(	(	PUNCT
biomedich-729	52	27	ogu	ogu	NOUN
biomedich-729	52	28	&	&	CCONJ
biomedich-729	52	29	maxa	maxa	NOUN
biomedich-729	52	30	,	,	PUNCT
biomedich-729	52	31	2000	2000	NUM
biomedich-729	52	32	;	;	PUNCT
biomedich-729	52	33	guengerich	guengerich	NOUN
biomedich-729	52	34	,	,	PUNCT
biomedich-729	52	35	2022	2022	NUM
biomedich-729	52	36	)	)	PUNCT
biomedich-729	52	37	.	.	PUNCT
biomedich-729	53	1	na+/k+–atpase	na+/k+–atpase	NOUN
biomedich-729	53	2	and	and	CCONJ
biomedich-729	53	3	nadh	nadh	NOUN
biomedich-729	53	4	dehydrogenase	dehydrogenase	NOUN
biomedich-729	53	5	1	1	NUM
biomedich-729	53	6	are	be	AUX
biomedich-729	53	7	important	important	ADJ
biomedich-729	53	8	for	for	ADP
biomedich-729	53	9	the	the	DET
biomedich-729	53	10	maintenance	maintenance	NOUN
biomedich-729	53	11	of	of	ADP
biomedich-729	53	12	cellular	cellular	ADJ
biomedich-729	53	13	redox	redox	ADJ
biomedich-729	53	14	balance	balance	NOUN
biomedich-729	53	15	and	and	CCONJ
biomedich-729	53	16	mitochondrial	mitochondrial	ADJ
biomedich-729	53	17	membrane	membrane	NOUN
biomedich-729	53	18	potential	potential	NOUN
biomedich-729	53	19	(	(	PUNCT
biomedich-729	53	20	pivovarov	pivovarov	NOUN
biomedich-729	53	21	et	et	PROPN
biomedich-729	53	22	al	al	PROPN
biomedich-729	53	23	.	.	PROPN
biomedich-729	53	24	,	,	PUNCT
biomedich-729	53	25	2019	2019	NUM
biomedich-729	53	26	;	;	PUNCT
biomedich-729	53	27	herrmann	herrmann	PROPN
biomedich-729	53	28	&	&	CCONJ
biomedich-729	53	29	riemer	riemer	PROPN
biomedich-729	53	30	,	,	PUNCT
biomedich-729	53	31	2021	2021	NUM
biomedich-729	53	32	)	)	PUNCT
biomedich-729	53	33	.	.	PUNCT
biomedich-729	54	1	preparation	preparation	NOUN
biomedich-729	54	2	of	of	ADP
biomedich-729	54	3	protein	protein	NOUN
biomedich-729	54	4	molecules	molecule	NOUN
biomedich-729	54	5	the	the	DET
biomedich-729	54	6	crystal	crystal	NOUN
biomedich-729	54	7	structures	structure	NOUN
biomedich-729	54	8	of	of	ADP
biomedich-729	54	9	human	human	ADJ
biomedich-729	54	10	cyp1a2	cyp1a2	PROPN
biomedich-729	54	11	(	(	PUNCT
biomedich-729	54	12	pdb	pdb	PROPN
biomedich-729	54	13	i	i	PROPN
biomedich-729	54	14	d	d	PROPN
biomedich-729	54	15	:	:	PUNCT
biomedich-729	54	16	2hi4	2hi4	NUM
biomedich-729	54	17	)	)	PUNCT
biomedich-729	54	18	,	,	PUNCT
biomedich-729	54	19	cyp2c19	cyp2c19	PROPN
biomedich-729	54	20	(	(	PUNCT
biomedich-729	54	21	pdb	pdb	PROPN
biomedich-729	54	22	i	i	PROPN
biomedich-729	54	23	d	d	PROPN
biomedich-729	54	24	:	:	PUNCT
biomedich-729	54	25	4ggs	4ggs	NUM
biomedich-729	54	26	)	)	PUNCT
biomedich-729	54	27	,	,	PUNCT
biomedich-729	54	28	na+/k+–atpase	na+/k+–atpase	PROPN
biomedich-729	54	29	(	(	PUNCT
biomedich-729	54	30	pdb	pdb	PROPN
biomedich-729	54	31	i	i	PROPN
biomedich-729	54	32	d	d	PROPN
biomedich-729	54	33	:	:	PUNCT
biomedich-729	54	34	7e1z	7e1z	NUM
biomedich-729	54	35	)	)	PUNCT
biomedich-729	54	36	,	,	PUNCT
biomedich-729	54	37	and	and	CCONJ
biomedich-729	54	38	nadh	nadh	NOUN
biomedich-729	54	39	dehydrogenase	dehydrogenase	NOUN
biomedich-729	54	40	1	1	NUM
biomedich-729	54	41	(	(	PUNCT
biomedich-729	54	42	pdb	pdb	PROPN
biomedich-729	54	43	i	i	PROPN
biomedich-729	54	44	d	d	PROPN
biomedich-729	54	45	:	:	PUNCT
biomedich-729	54	46	5xtd	5xtd	NUM
biomedich-729	54	47	)	)	PUNCT
biomedich-729	54	48	were	be	AUX
biomedich-729	54	49	downloaded	download	VERB
biomedich-729	54	50	from	from	ADP
biomedich-729	54	51	protein	protein	NOUN
biomedich-729	54	52	data	datum	NOUN
biomedich-729	54	53	bank	bank	NOUN
biomedich-729	54	54	(	(	PUNCT
biomedich-729	54	55	www.rcsb.org	www.rcsb.org	X
biomedich-729	54	56	)	)	PUNCT
biomedich-729	54	57	.	.	PUNCT
biomedich-729	55	1	using	use	VERB
biomedich-729	55	2	autodock4	autodock4	PROPN
biomedich-729	55	3	molecular	molecular	ADJ
biomedich-729	55	4	docking	docking	NOUN
biomedich-729	55	5	software	software	NOUN
biomedich-729	55	6	,	,	PUNCT
biomedich-729	55	7	the	the	DET
biomedich-729	55	8	protein	protein	NOUN
biomedich-729	55	9	subunits	subunit	NOUN
biomedich-729	55	10	(	(	PUNCT
biomedich-729	55	11	polypeptide	polypeptide	ADJ
biomedich-729	55	12	chains	chain	NOUN
biomedich-729	55	13	)	)	PUNCT
biomedich-729	55	14	of	of	ADP
biomedich-729	55	15	cyp2c19	cyp2c19	NOUN
biomedich-729	55	16	and	and	CCONJ
biomedich-729	55	17	na+/k+–atpase	na+/k+–atpase	PROPN
biomedich-729	55	18	were	be	AUX
biomedich-729	55	19	separated	separate	VERB
biomedich-729	55	20	and	and	CCONJ
biomedich-729	55	21	treated	treat	VERB
biomedich-729	55	22	individually	individually	ADV
biomedich-729	55	23	;	;	PUNCT
biomedich-729	55	24	cyp1a2	cyp1a2	NOUN
biomedich-729	55	25	comprises	comprise	VERB
biomedich-729	55	26	a	a	DET
biomedich-729	55	27	single	single	ADJ
biomedich-729	55	28	polypeptide	polypeptide	ADJ
biomedich-729	55	29	chain	chain	NOUN
biomedich-729	55	30	.	.	PUNCT
biomedich-729	56	1	nadh	nadh	PROPN
biomedich-729	56	2	dehydrogenase	dehydrogenase	NOUN
biomedich-729	56	3	1	1	NUM
biomedich-729	56	4	comprises	comprise	VERB
biomedich-729	56	5	44	44	NUM
biomedich-729	56	6	subunits	subunit	NOUN
biomedich-729	56	7	,	,	PUNCT
biomedich-729	56	8	the	the	DET
biomedich-729	56	9	chains	chain	NOUN
biomedich-729	56	10	were	be	AUX
biomedich-729	56	11	divided	divide	VERB
biomedich-729	56	12	into	into	ADP
biomedich-729	56	13	three	three	NUM
biomedich-729	56	14	clusters	cluster	NOUN
biomedich-729	56	15	based	base	VERB
biomedich-729	56	16	on	on	ADP
biomedich-729	56	17	proximity	proximity	NOUN
biomedich-729	56	18	to	to	ADP
biomedich-729	56	19	one	one	NUM
biomedich-729	56	20	another	another	DET
biomedich-729	56	21	;	;	PUNCT
biomedich-729	56	22	cluster	cluster	NOUN
biomedich-729	56	23	1	1	NUM
biomedich-729	56	24	contains	contain	VERB
biomedich-729	56	25	8	8	NUM
biomedich-729	56	26	polypeptide	polypeptide	ADJ
biomedich-729	56	27	chains	chain	NOUN
biomedich-729	56	28	:	:	PUNCT
biomedich-729	56	29	a	a	PRON
biomedich-729	56	30	,	,	PUNCT
biomedich-729	56	31	f	f	X
biomedich-729	56	32	,	,	PUNCT
biomedich-729	56	33	k	k	PROPN
biomedich-729	56	34	,	,	PUNCT
biomedich-729	56	35	l	l	PROPN
biomedich-729	56	36	,	,	PUNCT
biomedich-729	56	37	m	m	PROPN
biomedich-729	56	38	,	,	PUNCT
biomedich-729	56	39	n	n	CCONJ
biomedich-729	56	40	,	,	PUNCT
biomedich-729	56	41	o	o	PROPN
biomedich-729	56	42	and	and	CCONJ
biomedich-729	56	43	t	t	PROPN
biomedich-729	56	44	;	;	PUNCT
biomedich-729	56	45	cluster	cluster	NOUN
biomedich-729	56	46	2	2	NUM
biomedich-729	56	47	contains	contain	VERB
biomedich-729	56	48	16	16	NUM
biomedich-729	56	49	polypeptide	polypeptide	ADJ
biomedich-729	56	50	chains	chain	NOUN
biomedich-729	56	51	:	:	PUNCT
biomedich-729	56	52	b	b	X
biomedich-729	56	53	,	,	PUNCT
biomedich-729	56	54	c	c	X
biomedich-729	56	55	,	,	PUNCT
biomedich-729	56	56	e	e	NOUN
biomedich-729	56	57	,	,	PUNCT
biomedich-729	56	58	g	g	PROPN
biomedich-729	56	59	,	,	PUNCT
biomedich-729	56	60	h	h	NOUN
biomedich-729	56	61	,	,	PUNCT
biomedich-729	56	62	i	i	PRON
biomedich-729	56	63	,	,	PUNCT
biomedich-729	56	64	j	j	PROPN
biomedich-729	56	65	,	,	PUNCT
biomedich-729	56	66	j	j	PROPN
biomedich-729	56	67	,	,	PUNCT
biomedich-729	56	68	m	m	PROPN
biomedich-729	56	69	,	,	PUNCT
biomedich-729	56	70	p	p	X
biomedich-729	56	71	,	,	PUNCT
biomedich-729	56	72	q	q	ADJ
biomedich-729	56	73	,	,	PUNCT
biomedich-729	56	74	s	s	PROPN
biomedich-729	56	75	,	,	PUNCT
biomedich-729	56	76	s	s	X
biomedich-729	56	77	,	,	PUNCT
biomedich-729	56	78	u	u	NOUN
biomedich-729	56	79	,	,	PUNCT
biomedich-729	56	80	w	w	PROPN
biomedich-729	56	81	and	and	CCONJ
biomedich-729	56	82	w	w	PROPN
biomedich-729	56	83	;	;	PUNCT
biomedich-729	56	84	while	while	SCONJ
biomedich-729	56	85	cluster	cluster	NOUN
biomedich-729	56	86	3	3	NUM
biomedich-729	56	87	contains	contain	VERB
biomedich-729	56	88	20	20	NUM
biomedich-729	56	89	polypeptide	polypeptide	ADJ
biomedich-729	56	90	chains	chain	NOUN
biomedich-729	56	91	:	:	PUNCT
biomedich-729	56	92	a	a	DET
biomedich-729	56	93	,	,	PUNCT
biomedich-729	56	94	b	b	NOUN
biomedich-729	56	95	,	,	PUNCT
biomedich-729	56	96	c	c	NOUN
biomedich-729	56	97	,	,	PUNCT
biomedich-729	56	98	d	d	NOUN
biomedich-729	56	99	,	,	PUNCT
biomedich-729	56	100	e	e	NOUN
biomedich-729	56	101	,	,	PUNCT
biomedich-729	56	102	f	f	PROPN
biomedich-729	56	103	,	,	PUNCT
biomedich-729	56	104	g	g	PROPN
biomedich-729	56	105	,	,	PUNCT
biomedich-729	56	106	h	h	NOUN
biomedich-729	56	107	,	,	PUNCT
biomedich-729	56	108	i	i	PRON
biomedich-729	56	109	,	,	PUNCT
biomedich-729	56	110	k	k	PROPN
biomedich-729	56	111	,	,	PUNCT
biomedich-729	56	112	l	l	NOUN
biomedich-729	56	113	,	,	PUNCT
biomedich-729	56	114	n	n	CCONJ
biomedich-729	56	115	,	,	PUNCT
biomedich-729	56	116	o	o	NOUN
biomedich-729	56	117	,	,	PUNCT
biomedich-729	56	118	p	p	X
biomedich-729	56	119	,	,	PUNCT
biomedich-729	56	120	r	r	NOUN
biomedich-729	56	121	,	,	PUNCT
biomedich-729	56	122	v	v	NOUN
biomedich-729	56	123	,	,	PUNCT
biomedich-729	56	124	v	v	NOUN
biomedich-729	56	125	,	,	PUNCT
biomedich-729	56	126	x	x	NOUN
biomedich-729	56	127	,	,	PUNCT
biomedich-729	56	128	y	y	PROPN
biomedich-729	56	129	and	and	CCONJ
biomedich-729	56	130	z.	z.	PROPN
biomedich-729	56	131	water	water	NOUN
biomedich-729	56	132	molecules	molecule	NOUN
biomedich-729	56	133	,	,	PUNCT
biomedich-729	56	134	other	other	ADJ
biomedich-729	56	135	heteroatoms	heteroatom	NOUN
biomedich-729	56	136	,	,	PUNCT
biomedich-729	56	137	and	and	CCONJ
biomedich-729	56	138	non	non	ADJ
biomedich-729	56	139	-	-	ADJ
biomedich-729	56	140	standard	standard	ADJ
biomedich-729	56	141	amino	amino	ADJ
biomedich-729	56	142	acid	acid	NOUN
biomedich-729	56	143	molecules	molecule	NOUN
biomedich-729	56	144	were	be	AUX
biomedich-729	56	145	deleted	delete	VERB
biomedich-729	56	146	from	from	ADP
biomedich-729	56	147	the	the	DET
biomedich-729	56	148	polypeptide	polypeptide	ADJ
biomedich-729	56	149	chains	chain	NOUN
biomedich-729	56	150	.	.	PUNCT
biomedich-729	57	1	non	non	ADJ
biomedich-729	57	2	-	-	ADJ
biomedich-729	57	3	polar	polar	ADJ
biomedich-729	57	4	hydrogen	hydrogen	NOUN
biomedich-729	57	5	atoms	atom	NOUN
biomedich-729	57	6	and	and	CCONJ
biomedich-729	57	7	kollman	kollman	NOUN
biomedich-729	57	8	charges	charge	NOUN
biomedich-729	57	9	were	be	AUX
biomedich-729	57	10	added	add	VERB
biomedich-729	57	11	to	to	ADP
biomedich-729	57	12	the	the	DET
biomedich-729	57	13	chains	chain	NOUN
biomedich-729	57	14	.	.	PUNCT
biomedich-729	58	1	the	the	DET
biomedich-729	58	2	ajayi	ajayi	NOUN
biomedich-729	58	3	et	et	PROPN
biomedich-729	58	4	al	al	PROPN
biomedich-729	58	5	.	.	PROPN
biomedich-729	58	6	–	–	PUNCT
biomedich-729	58	7	toxicity	toxicity	NOUN
biomedich-729	58	8	prediction	prediction	NOUN
biomedich-729	58	9	of	of	ADP
biomedich-729	58	10	cola	cola	PROPN
biomedich-729	58	11	rostrata	rostrata	PROPN
biomedich-729	58	12	epicarp	epicarp	ADJ
biomedich-729	58	13	371	371	NUM
biomedich-729	58	14	polypeptide	polypeptide	ADJ
biomedich-729	58	15	chains	chain	NOUN
biomedich-729	58	16	were	be	AUX
biomedich-729	58	17	checked	check	VERB
biomedich-729	58	18	for	for	ADP
biomedich-729	58	19	missing	miss	VERB
biomedich-729	58	20	atoms	atom	NOUN
biomedich-729	58	21	,	,	PUNCT
biomedich-729	58	22	and	and	CCONJ
biomedich-729	58	23	repairs	repair	NOUN
biomedich-729	58	24	of	of	ADP
biomedich-729	58	25	missing	miss	VERB
biomedich-729	58	26	atoms	atom	NOUN
biomedich-729	58	27	were	be	AUX
biomedich-729	58	28	done	do	VERB
biomedich-729	58	29	.	.	PUNCT
biomedich-729	59	1	the	the	DET
biomedich-729	59	2	atoms	atom	NOUN
biomedich-729	59	3	of	of	ADP
biomedich-729	59	4	the	the	DET
biomedich-729	59	5	polypeptide	polypeptide	ADJ
biomedich-729	59	6	chains	chain	NOUN
biomedich-729	59	7	were	be	AUX
biomedich-729	59	8	formatted	format	VERB
biomedich-729	59	9	as	as	ADP
biomedich-729	59	10	autodock4	autodock4	PROPN
biomedich-729	59	11	molecules	molecule	NOUN
biomedich-729	59	12	,	,	PUNCT
biomedich-729	59	13	and	and	CCONJ
biomedich-729	59	14	the	the	DET
biomedich-729	59	15	chains	chain	NOUN
biomedich-729	59	16	were	be	AUX
biomedich-729	59	17	saved	save	VERB
biomedich-729	59	18	in	in	ADP
biomedich-729	59	19	pdbqt	pdbqt	ADJ
biomedich-729	59	20	format	format	NOUN
biomedich-729	59	21	.	.	PUNCT
biomedich-729	60	1	preparation	preparation	NOUN
biomedich-729	60	2	of	of	ADP
biomedich-729	60	3	ligand	ligand	ADJ
biomedich-729	60	4	molecules	molecule	NOUN
biomedich-729	60	5	using	use	VERB
biomedich-729	60	6	the	the	DET
biomedich-729	60	7	“	"	PUNCT
biomedich-729	60	8	draw	draw	ADJ
biomedich-729	60	9	structure	structure	NOUN
biomedich-729	60	10	”	"	PUNCT
biomedich-729	60	11	provision	provision	NOUN
biomedich-729	60	12	on	on	ADP
biomedich-729	60	13	pubchem	pubchem	NOUN
biomedich-729	60	14	platform	platform	NOUN
biomedich-729	60	15	,	,	PUNCT
biomedich-729	60	16	the	the	DET
biomedich-729	60	17	smiles	smile	NOUN
biomedich-729	60	18	notation	notation	NOUN
biomedich-729	60	19	of	of	ADP
biomedich-729	60	20	three	three	NUM
biomedich-729	60	21	components	component	NOUN
biomedich-729	60	22	of	of	ADP
biomedich-729	60	23	the	the	DET
biomedich-729	60	24	fractions	fraction	NOUN
biomedich-729	60	25	were	be	AUX
biomedich-729	60	26	used	use	VERB
biomedich-729	60	27	to	to	PART
biomedich-729	60	28	obtain	obtain	VERB
biomedich-729	60	29	their	their	PRON
biomedich-729	60	30	mdl	mdl	NOUN
biomedich-729	60	31	molfile	molfile	NOUN
biomedich-729	60	32	which	which	PRON
biomedich-729	60	33	were	be	AUX
biomedich-729	60	34	then	then	ADV
biomedich-729	60	35	converted	convert	VERB
biomedich-729	60	36	to	to	ADP
biomedich-729	60	37	mol2	mol2	PROPN
biomedich-729	60	38	file	file	NOUN
biomedich-729	60	39	with	with	ADP
biomedich-729	60	40	discovery	discovery	NOUN
biomedich-729	60	41	studio	studio	NOUN
biomedich-729	60	42	2021	2021	NUM
biomedich-729	60	43	software	software	NOUN
biomedich-729	60	44	.	.	PUNCT
biomedich-729	61	1	the	the	DET
biomedich-729	61	2	structures	structure	NOUN
biomedich-729	61	3	were	be	AUX
biomedich-729	61	4	converted	convert	VERB
biomedich-729	61	5	to	to	ADP
biomedich-729	61	6	their	their	PRON
biomedich-729	61	7	pdbqt	pdbqt	ADJ
biomedich-729	61	8	format	format	NOUN
biomedich-729	61	9	on	on	ADP
biomedich-729	61	10	autodock4	autodock4	PROPN
biomedich-729	61	11	after	after	SCONJ
biomedich-729	61	12	hydrogen	hydrogen	NOUN
biomedich-729	61	13	atoms	atom	NOUN
biomedich-729	61	14	had	have	AUX
biomedich-729	61	15	been	be	AUX
biomedich-729	61	16	added	add	VERB
biomedich-729	61	17	to	to	ADP
biomedich-729	61	18	each	each	DET
biomedich-729	61	19	compound	compound	NOUN
biomedich-729	61	20	and	and	CCONJ
biomedich-729	61	21	the	the	DET
biomedich-729	61	22	gasteiger	gasteiger	NOUN
biomedich-729	61	23	charges	charge	NOUN
biomedich-729	61	24	computed	compute	VERB
biomedich-729	61	25	.	.	PUNCT
biomedich-729	62	1	docking	dock	VERB
biomedich-729	62	2	experiments	experiment	NOUN
biomedich-729	62	3	blind	blind	ADJ
biomedich-729	62	4	docking	docking	NOUN
biomedich-729	62	5	was	be	AUX
biomedich-729	62	6	done	do	VERB
biomedich-729	62	7	with	with	ADP
biomedich-729	62	8	the	the	DET
biomedich-729	62	9	grid	grid	NOUN
biomedich-729	62	10	box	box	PROPN
biomedich-729	62	11	coordinates	coordinate	NOUN
biomedich-729	62	12	covering	cover	VERB
biomedich-729	62	13	the	the	DET
biomedich-729	62	14	entire	entire	ADJ
biomedich-729	62	15	atoms	atom	NOUN
biomedich-729	62	16	of	of	ADP
biomedich-729	62	17	the	the	DET
biomedich-729	62	18	polypeptide	polypeptide	ADJ
biomedich-729	62	19	chains	chain	NOUN
biomedich-729	62	20	,	,	PUNCT
biomedich-729	62	21	but	but	CCONJ
biomedich-729	62	22	in	in	ADP
biomedich-729	62	23	few	few	ADJ
biomedich-729	62	24	cases	case	NOUN
biomedich-729	62	25	,	,	PUNCT
biomedich-729	62	26	due	due	ADP
biomedich-729	62	27	to	to	ADP
biomedich-729	62	28	the	the	DET
biomedich-729	62	29	size	size	NOUN
biomedich-729	62	30	of	of	ADP
biomedich-729	62	31	the	the	DET
biomedich-729	62	32	polypeptide	polypeptide	ADJ
biomedich-729	62	33	chains	chain	NOUN
biomedich-729	62	34	some	some	DET
biomedich-729	62	35	atoms	atom	NOUN
biomedich-729	62	36	were	be	AUX
biomedich-729	62	37	not	not	PART
biomedich-729	62	38	covered	cover	VERB
biomedich-729	62	39	by	by	ADP
biomedich-729	62	40	the	the	DET
biomedich-729	62	41	grid	grid	NOUN
biomedich-729	62	42	.	.	PUNCT
biomedich-729	63	1	the	the	DET
biomedich-729	63	2	genetic	genetic	ADJ
biomedich-729	63	3	algorithm	algorithm	NOUN
biomedich-729	63	4	(	(	PUNCT
biomedich-729	63	5	ga	ga	NOUN
biomedich-729	63	6	)	)	PUNCT
biomedich-729	63	7	parameters	parameter	NOUN
biomedich-729	63	8	include	include	VERB
biomedich-729	63	9	,	,	PUNCT
biomedich-729	63	10	number	number	NOUN
biomedich-729	63	11	of	of	ADP
biomedich-729	63	12	ga	ga	PROPN
biomedich-729	63	13	runs	run	NOUN
biomedich-729	63	14	(	(	PUNCT
biomedich-729	63	15	30	30	NUM
biomedich-729	63	16	)	)	PUNCT
biomedich-729	63	17	,	,	PUNCT
biomedich-729	63	18	and	and	CCONJ
biomedich-729	63	19	population	population	NOUN
biomedich-729	63	20	size	size	NOUN
biomedich-729	63	21	(	(	PUNCT
biomedich-729	63	22	300	300	NUM
biomedich-729	63	23	)	)	PUNCT
biomedich-729	63	24	.	.	PUNCT
biomedich-729	64	1	for	for	ADP
biomedich-729	64	2	each	each	DET
biomedich-729	64	3	docking	dock	VERB
biomedich-729	64	4	experiment	experiment	NOUN
biomedich-729	64	5	,	,	PUNCT
biomedich-729	64	6	the	the	DET
biomedich-729	64	7	best	good	ADJ
biomedich-729	64	8	pose	pose	VERB
biomedich-729	64	9	i.e.	i.e.	X
biomedich-729	64	10	the	the	DET
biomedich-729	64	11	one	one	NOUN
biomedich-729	64	12	with	with	ADP
biomedich-729	64	13	the	the	DET
biomedich-729	64	14	highest	high	ADJ
biomedich-729	64	15	binding	bind	VERB
biomedich-729	64	16	energy	energy	NOUN
biomedich-729	64	17	,	,	PUNCT
biomedich-729	64	18	and	and	CCONJ
biomedich-729	64	19	the	the	DET
biomedich-729	64	20	binding	bind	VERB
biomedich-729	64	21	interactions	interaction	NOUN
biomedich-729	64	22	between	between	ADP
biomedich-729	64	23	the	the	DET
biomedich-729	64	24	ligands	ligand	NOUN
biomedich-729	64	25	and	and	CCONJ
biomedich-729	64	26	the	the	DET
biomedich-729	64	27	polypeptide	polypeptide	ADJ
biomedich-729	64	28	chains	chain	NOUN
biomedich-729	64	29	were	be	AUX
biomedich-729	64	30	visualized	visualize	VERB
biomedich-729	64	31	on	on	ADP
biomedich-729	64	32	discovery	discovery	NOUN
biomedich-729	64	33	studio	studio	NOUN
biomedich-729	64	34	2021	2021	NUM
biomedich-729	64	35	software	software	NOUN
biomedich-729	64	36	.	.	PUNCT
biomedich-729	65	1	results	result	NOUN
biomedich-729	65	2	and	and	CCONJ
biomedich-729	65	3	discussion	discussion	NOUN
biomedich-729	65	4	results	result	VERB
biomedich-729	65	5	chemical	chemical	ADJ
biomedich-729	65	6	constituents	constituent	NOUN
biomedich-729	65	7	of	of	ADP
biomedich-729	65	8	polar	polar	ADJ
biomedich-729	65	9	and	and	CCONJ
biomedich-729	65	10	non	non	ADJ
biomedich-729	65	11	-	-	ADJ
biomedich-729	65	12	polar	polar	ADJ
biomedich-729	65	13	fractions	fraction	NOUN
biomedich-729	65	14	of	of	ADP
biomedich-729	65	15	c.	c.	PROPN
biomedich-729	65	16	rostrata	rostrata	PROPN
biomedich-729	65	17	epicarp	epicarp	ADJ
biomedich-729	65	18	were	be	AUX
biomedich-729	65	19	identified	identify	VERB
biomedich-729	65	20	using	use	VERB
biomedich-729	65	21	gc	gc	PROPN
biomedich-729	65	22	-	-	PUNCT
biomedich-729	65	23	ms	ms	NOUN
biomedich-729	65	24	analysis	analysis	NOUN
biomedich-729	65	25	.	.	PUNCT
biomedich-729	66	1	the	the	DET
biomedich-729	66	2	inhibitory	inhibitory	ADJ
biomedich-729	66	3	effects	effect	NOUN
biomedich-729	66	4	of	of	ADP
biomedich-729	66	5	these	these	DET
biomedich-729	66	6	components	component	NOUN
biomedich-729	66	7	on	on	ADP
biomedich-729	66	8	cyp450	cyp450	NOUN
biomedich-729	66	9	family	family	NOUN
biomedich-729	66	10	enzymes	enzyme	NOUN
biomedich-729	66	11	were	be	AUX
biomedich-729	66	12	evaluated	evaluate	VERB
biomedich-729	66	13	as	as	SCONJ
biomedich-729	66	14	presented	present	VERB
biomedich-729	66	15	.	.	PUNCT
biomedich-729	67	1	gc	gc	PROPN
biomedich-729	67	2	-	-	PUNCT
biomedich-729	67	3	ms	ms	PROPN
biomedich-729	67	4	identification	identification	NOUN
biomedich-729	67	5	of	of	ADP
biomedich-729	67	6	constituents	constituent	NOUN
biomedich-729	67	7	the	the	DET
biomedich-729	67	8	constituents	constituent	NOUN
biomedich-729	67	9	of	of	ADP
biomedich-729	67	10	the	the	DET
biomedich-729	67	11	polar	polar	ADJ
biomedich-729	67	12	and	and	CCONJ
biomedich-729	67	13	non	non	ADJ
biomedich-729	67	14	-	-	ADJ
biomedich-729	67	15	polar	polar	ADJ
biomedich-729	67	16	fractions	fraction	NOUN
biomedich-729	67	17	of	of	ADP
biomedich-729	67	18	the	the	DET
biomedich-729	67	19	epicarp	epicarp	NOUN
biomedich-729	67	20	of	of	ADP
biomedich-729	67	21	c.	c.	PROPN
biomedich-729	67	22	rostrata	rostrata	PROPN
biomedich-729	67	23	identified	identify	VERB
biomedich-729	67	24	via	via	ADP
biomedich-729	67	25	gc	gc	PROPN
biomedich-729	67	26	-	-	PROPN
biomedich-729	67	27	ms	ms	PROPN
biomedich-729	67	28	and	and	CCONJ
biomedich-729	67	29	their	their	PRON
biomedich-729	67	30	proportion	proportion	NOUN
biomedich-729	67	31	(	(	PUNCT
biomedich-729	67	32	area	area	NOUN
biomedich-729	67	33	%	%	NOUN
biomedich-729	67	34	)	)	PUNCT
biomedich-729	67	35	in	in	ADP
biomedich-729	67	36	the	the	DET
biomedich-729	67	37	fractions	fraction	NOUN
biomedich-729	67	38	are	be	AUX
biomedich-729	67	39	presented	present	VERB
biomedich-729	67	40	in	in	ADP
biomedich-729	67	41	table	table	NOUN
biomedich-729	67	42	1	1	NUM
biomedich-729	67	43	.	.	PUNCT
biomedich-729	68	1	a	a	DET
biomedich-729	68	2	total	total	NOUN
biomedich-729	68	3	of	of	ADP
biomedich-729	68	4	51	51	NUM
biomedich-729	68	5	compounds	compound	NOUN
biomedich-729	68	6	were	be	AUX
biomedich-729	68	7	identified	identify	VERB
biomedich-729	68	8	in	in	ADP
biomedich-729	68	9	the	the	DET
biomedich-729	68	10	fractions	fraction	NOUN
biomedich-729	68	11	,	,	PUNCT
biomedich-729	68	12	29	29	NUM
biomedich-729	68	13	in	in	ADP
biomedich-729	68	14	the	the	DET
biomedich-729	68	15	non	non	ADJ
biomedich-729	68	16	-	-	ADJ
biomedich-729	68	17	polar	polar	ADJ
biomedich-729	68	18	fraction	fraction	NOUN
biomedich-729	68	19	and	and	CCONJ
biomedich-729	68	20	22	22	NUM
biomedich-729	68	21	in	in	ADP
biomedich-729	68	22	the	the	DET
biomedich-729	68	23	polar	polar	ADJ
biomedich-729	68	24	fraction	fraction	NOUN
biomedich-729	68	25	,	,	PUNCT
biomedich-729	68	26	with	with	ADP
biomedich-729	68	27	heptadecanoic	heptadecanoic	ADJ
biomedich-729	68	28	acid	acid	NOUN
biomedich-729	68	29	methyl	methyl	NOUN
biomedich-729	68	30	ester	ester	NOUN
biomedich-729	68	31	,	,	PUNCT
biomedich-729	68	32	nheptadecanoic	nheptadecanoic	ADJ
biomedich-729	68	33	acid	acid	NOUN
biomedich-729	68	34	and	and	CCONJ
biomedich-729	68	35	stigmasterol	stigmasterol	NOUN
biomedich-729	68	36	co	co	VERB
biomedich-729	68	37	-	-	NOUN
biomedich-729	68	38	partitioning	partition	VERB
biomedich-729	68	39	into	into	ADP
biomedich-729	68	40	both	both	DET
biomedich-729	68	41	fractions	fraction	NOUN
biomedich-729	68	42	.	.	PUNCT
biomedich-729	69	1	inhibitory	inhibitory	ADJ
biomedich-729	69	2	effects	effect	NOUN
biomedich-729	69	3	of	of	ADP
biomedich-729	69	4	components	component	NOUN
biomedich-729	69	5	of	of	ADP
biomedich-729	69	6	the	the	DET
biomedich-729	69	7	extract	extract	NOUN
biomedich-729	69	8	fractions	fraction	NOUN
biomedich-729	69	9	on	on	ADP
biomedich-729	69	10	cyp450	cyp450	NOUN
biomedich-729	69	11	family	family	NOUN
biomedich-729	69	12	members	member	NOUN
biomedich-729	69	13	the	the	DET
biomedich-729	69	14	detoxification	detoxification	NOUN
biomedich-729	69	15	of	of	ADP
biomedich-729	69	16	drug	drug	NOUN
biomedich-729	69	17	compounds	compound	NOUN
biomedich-729	69	18	in	in	ADP
biomedich-729	69	19	humans	human	NOUN
biomedich-729	69	20	is	be	AUX
biomedich-729	69	21	chiefly	chiefly	ADV
biomedich-729	69	22	done	do	VERB
biomedich-729	69	23	by	by	ADP
biomedich-729	69	24	members	member	NOUN
biomedich-729	69	25	of	of	ADP
biomedich-729	69	26	the	the	DET
biomedich-729	69	27	cytochrome	cytochrome	NOUN
biomedich-729	69	28	p450	p450	PROPN
biomedich-729	69	29	(	(	PUNCT
biomedich-729	69	30	cyp	cyp	ADJ
biomedich-729	69	31	)	)	PUNCT
biomedich-729	69	32	families	family	NOUN
biomedich-729	69	33	.	.	PUNCT
biomedich-729	70	1	the	the	DET
biomedich-729	70	2	potential	potential	NOUN
biomedich-729	70	3	of	of	ADP
biomedich-729	70	4	the	the	DET
biomedich-729	70	5	components	component	NOUN
biomedich-729	70	6	of	of	ADP
biomedich-729	70	7	the	the	DET
biomedich-729	70	8	polar	polar	ADJ
biomedich-729	70	9	and	and	CCONJ
biomedich-729	70	10	non	non	ADJ
biomedich-729	70	11	-	-	ADJ
biomedich-729	70	12	polar	polar	ADJ
biomedich-729	70	13	fractions	fraction	NOUN
biomedich-729	70	14	of	of	ADP
biomedich-729	70	15	c.	c.	PROPN
biomedich-729	70	16	rostrata	rostrata	PROPN
biomedich-729	70	17	epicarp	epicarp	ADJ
biomedich-729	70	18	extract	extract	VERB
biomedich-729	70	19	to	to	PART
biomedich-729	70	20	bind	bind	VERB
biomedich-729	70	21	to	to	ADP
biomedich-729	70	22	and	and	CCONJ
biomedich-729	70	23	inhibit	inhibit	VERB
biomedich-729	70	24	members	member	NOUN
biomedich-729	70	25	of	of	ADP
biomedich-729	70	26	cyp	cyp	ADJ
biomedich-729	70	27	family	family	NOUN
biomedich-729	70	28	is	be	AUX
biomedich-729	70	29	presented	present	VERB
biomedich-729	70	30	in	in	ADP
biomedich-729	70	31	table	table	NOUN
biomedich-729	70	32	2	2	NUM
biomedich-729	70	33	.	.	PUNCT
biomedich-729	71	1	a	a	DET
biomedich-729	71	2	total	total	NOUN
biomedich-729	71	3	of	of	ADP
biomedich-729	71	4	10	10	NUM
biomedich-729	71	5	compounds	compound	NOUN
biomedich-729	71	6	,	,	PUNCT
biomedich-729	71	7	five	five	NUM
biomedich-729	71	8	from	from	ADP
biomedich-729	71	9	each	each	DET
biomedich-729	71	10	extract	extract	NOUN
biomedich-729	71	11	fraction	fraction	NOUN
biomedich-729	71	12	,	,	PUNCT
biomedich-729	71	13	have	have	VERB
biomedich-729	71	14	very	very	ADV
biomedich-729	71	15	strong	strong	ADJ
biomedich-729	71	16	potential	potential	NOUN
biomedich-729	71	17	(	(	PUNCT
biomedich-729	71	18	probability	probability	NOUN
biomedich-729	71	19	between	between	ADP
biomedich-729	71	20	0.9	0.9	NUM
biomedich-729	71	21	and	and	CCONJ
biomedich-729	71	22	1.0	1.0	NUM
biomedich-729	71	23	)	)	PUNCT
biomedich-729	71	24	to	to	PART
biomedich-729	71	25	inhibit	inhibit	VERB
biomedich-729	71	26	cyp1a2	cyp1a2	PROPN
biomedich-729	71	27	,	,	PUNCT
biomedich-729	71	28	these	these	DET
biomedich-729	71	29	10	10	NUM
biomedich-729	71	30	compounds	compound	NOUN
biomedich-729	71	31	are	be	AUX
biomedich-729	71	32	(	(	PUNCT
biomedich-729	71	33	i	i	NOUN
biomedich-729	71	34	)	)	PUNCT
biomedich-729	71	35	3	3	NUM
biomedich-729	71	36	-	-	PUNCT
biomedich-729	71	37	cyclopentylpropionic	cyclopentylpropionic	ADJ
biomedich-729	71	38	acid	acid	NOUN
biomedich-729	71	39	,	,	PUNCT
biomedich-729	71	40	ethyl	ethyl	PROPN
biomedich-729	71	41	ester	ester	NOUN
biomedich-729	71	42	,	,	PUNCT
biomedich-729	71	43	(	(	PUNCT
biomedich-729	71	44	ii	ii	NOUN
biomedich-729	71	45	)	)	PUNCT
biomedich-729	71	46	cis-9	cis-9	ADV
biomedich-729	71	47	-	-	ADJ
biomedich-729	71	48	tetradecenoic	tetradecenoic	ADJ
biomedich-729	71	49	acid	acid	NOUN
biomedich-729	71	50	,	,	PUNCT
biomedich-729	71	51	propyl	propyl	ADJ
biomedich-729	71	52	ester	ester	NOUN
biomedich-729	71	53	,	,	PUNCT
biomedich-729	71	54	(	(	PUNCT
biomedich-729	71	55	iii	iii	NOUN
biomedich-729	71	56	)	)	PUNCT
biomedich-729	71	57	z	z	NOUN
biomedich-729	71	58	,	,	PUNCT
biomedich-729	71	59	z10,12	z10,12	PROPN
biomedich-729	71	60	-	-	PUNCT
biomedich-729	71	61	hexadecadien-1	hexadecadien-1	NOUN
biomedich-729	71	62	-	-	PUNCT
biomedich-729	71	63	ol	ol	NOUN
biomedich-729	71	64	acetate	acetate	NOUN
biomedich-729	71	65	,	,	PUNCT
biomedich-729	71	66	(	(	PUNCT
biomedich-729	71	67	iv	iv	X
biomedich-729	71	68	)	)	PUNCT
biomedich-729	71	69	7,10octadecadienoic	7,10octadecadienoic	NUM
biomedich-729	71	70	acid	acid	NOUN
biomedich-729	71	71	,	,	PUNCT
biomedich-729	71	72	methyl	methyl	NOUN
biomedich-729	71	73	ester	ester	NOUN
biomedich-729	71	74	,	,	PUNCT
biomedich-729	71	75	and	and	CCONJ
biomedich-729	71	76	(	(	PUNCT
biomedich-729	71	77	v	v	NOUN
biomedich-729	71	78	)	)	PUNCT
biomedich-729	71	79	z-8	z-8	NUM
biomedich-729	71	80	-	-	PUNCT
biomedich-729	71	81	methyl9	methyl9	NOUN
biomedich-729	71	82	-	-	PUNCT
biomedich-729	71	83	tetradecen-1	tetradecen-1	PRON
biomedich-729	71	84	-	-	PUNCT
biomedich-729	71	85	ol	ol	NOUN
biomedich-729	71	86	formate	formate	NOUN
biomedich-729	71	87	from	from	ADP
biomedich-729	71	88	the	the	DET
biomedich-729	71	89	non	non	ADJ
biomedich-729	71	90	-	-	ADJ
biomedich-729	71	91	polar	polar	ADJ
biomedich-729	71	92	fraction	fraction	NOUN
biomedich-729	71	93	;	;	PUNCT
biomedich-729	71	94	and	and	CCONJ
biomedich-729	71	95	(	(	PUNCT
biomedich-729	71	96	vi	vi	NOUN
biomedich-729	71	97	)	)	PUNCT
biomedich-729	71	98	7	7	NUM
biomedich-729	71	99	-	-	PUNCT
biomedich-729	71	100	pentadecyne	pentadecyne	NOUN
biomedich-729	71	101	,	,	PUNCT
biomedich-729	71	102	(	(	PUNCT
biomedich-729	71	103	vii	vii	PROPN
biomedich-729	71	104	)	)	PUNCT
biomedich-729	71	105	silicic	silicic	NOUN
biomedich-729	71	106	acid	acid	NOUN
biomedich-729	71	107	,	,	PUNCT
biomedich-729	71	108	diethyl	diethyl	NOUN
biomedich-729	71	109	bis(trimethylsilyl	bis(trimethylsilyl	NOUN
biomedich-729	71	110	)	)	PUNCT
biomedich-729	71	111	ester	ester	NOUN
biomedich-729	71	112	,	,	PUNCT
biomedich-729	71	113	(	(	PUNCT
biomedich-729	71	114	viii	viii	NOUN
biomedich-729	71	115	)	)	PUNCT
biomedich-729	71	116	4	4	NUM
biomedich-729	71	117	-	-	PUNCT
biomedich-729	71	118	methoxy-6	methoxy-6	NUM
biomedich-729	71	119	-	-	PUNCT
biomedich-729	71	120	methyl-5nitroisobenzofuran-1,3	methyl-5nitroisobenzofuran-1,3	NOUN
biomedich-729	71	121	-	-	PUNCT
biomedich-729	71	122	dione	dione	NOUN
biomedich-729	71	123	,	,	PUNCT
biomedich-729	71	124	(	(	PUNCT
biomedich-729	71	125	ix	ix	ADJ
biomedich-729	71	126	)	)	PUNCT
biomedich-729	71	127	2	2	NUM
biomedich-729	71	128	-	-	NUM
biomedich-729	71	129	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	71	130	,	,	PUNCT
biomedich-729	71	131	and	and	CCONJ
biomedich-729	71	132	(	(	PUNCT
biomedich-729	71	133	x	x	X
biomedich-729	71	134	)	)	PUNCT
biomedich-729	71	135	corynan-16	corynan-16	NOUN
biomedich-729	71	136	-	-	PUNCT
biomedich-729	71	137	carboxylic	carboxylic	ADJ
biomedich-729	71	138	acid	acid	NOUN
biomedich-729	71	139	,	,	PUNCT
biomedich-729	71	140	16,17	16,17	NUM
biomedich-729	71	141	-	-	PUNCT
biomedich-729	71	142	didehydro9,17	didehydro9,17	NOUN
biomedich-729	71	143	-	-	PUNCT
biomedich-729	71	144	dimethoxy-	dimethoxy-	NOUN
biomedich-729	71	145	,	,	PUNCT
biomedich-729	71	146	methyl	methyl	NOUN
biomedich-729	71	147	ester	ester	NOUN
biomedich-729	71	148	,	,	PUNCT
biomedich-729	71	149	(	(	PUNCT
biomedich-729	71	150	16e)from	16e)from	ADP
biomedich-729	71	151	the	the	DET
biomedich-729	71	152	polar	polar	ADJ
biomedich-729	71	153	fraction	fraction	NOUN
biomedich-729	71	154	.	.	PUNCT
biomedich-729	72	1	these	these	DET
biomedich-729	72	2	last	last	ADJ
biomedich-729	72	3	three	three	NUM
biomedich-729	72	4	compounds	compound	NOUN
biomedich-729	72	5	listed	list	VERB
biomedich-729	72	6	above	above	ADP
biomedich-729	72	7	(	(	PUNCT
biomedich-729	72	8	viii	viii	ADJ
biomedich-729	72	9	,	,	PUNCT
biomedich-729	72	10	ix	ix	ADV
biomedich-729	72	11	and	and	CCONJ
biomedich-729	72	12	x	x	X
biomedich-729	72	13	)	)	PUNCT
biomedich-729	72	14	also	also	ADV
biomedich-729	72	15	have	have	VERB
biomedich-729	72	16	strong	strong	ADJ
biomedich-729	72	17	potential	potential	NOUN
biomedich-729	72	18	to	to	PART
biomedich-729	72	19	inhibit	inhibit	VERB
biomedich-729	72	20	cyp2c19	cyp2c19	PROPN
biomedich-729	72	21	.	.	PUNCT
biomedich-729	73	1	2hydroxychalcone	2hydroxychalcone	NUM
biomedich-729	73	2	,	,	PUNCT
biomedich-729	73	3	compound	compound	VERB
biomedich-729	73	4	ix	ix	ADV
biomedich-729	73	5	in	in	ADP
biomedich-729	73	6	the	the	DET
biomedich-729	73	7	list	list	NOUN
biomedich-729	73	8	above	above	ADV
biomedich-729	73	9	,	,	PUNCT
biomedich-729	73	10	could	could	AUX
biomedich-729	73	11	also	also	ADV
biomedich-729	73	12	inhibit	inhibit	VERB
biomedich-729	73	13	cyp2c9	cyp2c9	NOUN
biomedich-729	73	14	and	and	CCONJ
biomedich-729	73	15	cyp3a4	cyp3a4	NOUN
biomedich-729	73	16	strongly	strongly	ADV
biomedich-729	73	17	,	,	PUNCT
biomedich-729	73	18	while	while	SCONJ
biomedich-729	73	19	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	73	20	-	-	PUNCT
biomedich-729	73	21	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	73	22	.	.	PUNCT
biomedich-729	73	23	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	73	24	,	,	PUNCT
biomedich-729	73	25	which	which	PRON
biomedich-729	73	26	is	be	AUX
biomedich-729	73	27	also	also	ADV
biomedich-729	73	28	present	present	ADJ
biomedich-729	73	29	in	in	ADP
biomedich-729	73	30	the	the	DET
biomedich-729	73	31	polar	polar	ADJ
biomedich-729	73	32	fraction	fraction	NOUN
biomedich-729	73	33	of	of	ADP
biomedich-729	73	34	the	the	DET
biomedich-729	73	35	extract	extract	NOUN
biomedich-729	73	36	,	,	PUNCT
biomedich-729	73	37	has	have	VERB
biomedich-729	73	38	very	very	ADV
biomedich-729	73	39	strong	strong	ADJ
biomedich-729	73	40	potential	potential	NOUN
biomedich-729	73	41	to	to	PART
biomedich-729	73	42	inhibit	inhibit	VERB
biomedich-729	73	43	cyp2d6	cyp2d6	NOUN
biomedich-729	73	44	.	.	PUNCT
biomedich-729	74	1	table	table	NOUN
biomedich-729	74	2	1	1	NUM
biomedich-729	74	3	.	.	PUNCT
biomedich-729	75	1	components	component	NOUN
biomedich-729	75	2	of	of	ADP
biomedich-729	75	3	the	the	DET
biomedich-729	75	4	fractions	fraction	NOUN
biomedich-729	75	5	of	of	ADP
biomedich-729	75	6	ethanol	ethanol	NOUN
biomedich-729	75	7	extract	extract	NOUN
biomedich-729	75	8	of	of	ADP
biomedich-729	75	9	cola	cola	PROPN
biomedich-729	75	10	rostrata	rostrata	PROPN
biomedich-729	75	11	epicarp	epicarp	PROPN
biomedich-729	75	12	sn	sn	PROPN
biomedich-729	75	13	non	non	ADJ
biomedich-729	75	14	-	-	ADJ
biomedich-729	75	15	polar	polar	ADJ
biomedich-729	75	16	fraction	fraction	NOUN
biomedich-729	75	17	area%	area%	PUNCT
biomedich-729	75	18	polar	polar	ADJ
biomedich-729	75	19	fraction	fraction	NOUN
biomedich-729	75	20	area%	area%	PUNCT
biomedich-729	75	21	1	1	NUM
biomedich-729	75	22	3	3	NUM
biomedich-729	75	23	-	-	PUNCT
biomedich-729	75	24	cyclopentylpropionic	cyclopentylpropionic	ADJ
biomedich-729	75	25	acid	acid	NOUN
biomedich-729	75	26	,	,	PUNCT
biomedich-729	75	27	ethyl	ethyl	PROPN
biomedich-729	75	28	ester	ester	NOUN
biomedich-729	75	29	0.60	0.60	NUM
biomedich-729	75	30	hexadecanoic	hexadecanoic	ADJ
biomedich-729	75	31	acid	acid	NOUN
biomedich-729	75	32	,	,	PUNCT
biomedich-729	75	33	methyl	methyl	NOUN
biomedich-729	75	34	ester	ester	NOUN
biomedich-729	75	35	1.48	1.48	NUM
biomedich-729	75	36	2	2	NUM
biomedich-729	75	37	azelaic	azelaic	PROPN
biomedich-729	75	38	acid	acid	NOUN
biomedich-729	75	39	,	,	PUNCT
biomedich-729	75	40	monoethyl	monoethyl	NOUN
biomedich-729	75	41	ester	ester	NOUN
biomedich-729	75	42	1.20	1.20	NUM
biomedich-729	75	43	n	n	CCONJ
biomedich-729	75	44	-	-	PUNCT
biomedich-729	75	45	hexadecanoic	hexadecanoic	NOUN
biomedich-729	75	46	acid	acid	PROPN
biomedich-729	75	47	8.57	8.57	NUM
biomedich-729	75	48	3	3	NUM
biomedich-729	75	49	tetradecanoic	tetradecanoic	ADJ
biomedich-729	75	50	acid	acid	NOUN
biomedich-729	75	51	0.67	0.67	NUM
biomedich-729	75	52	bicyclo[2.2.2]octane	bicyclo[2.2.2]octane	NOUN
biomedich-729	75	53	,	,	PUNCT
biomedich-729	75	54	2	2	NUM
biomedich-729	75	55	-	-	PUNCT
biomedich-729	75	56	methyl1.55	methyl1.55	NOUN
biomedich-729	75	57	4	4	NUM
biomedich-729	75	58	pentadecanoic	pentadecanoic	NOUN
biomedich-729	75	59	acid	acid	NOUN
biomedich-729	75	60	1.19	1.19	NUM
biomedich-729	75	61	2	2	NUM
biomedich-729	75	62	-	-	PUNCT
biomedich-729	75	63	myristynoyl	myristynoyl	NOUN
biomedich-729	75	64	-	-	PUNCT
biomedich-729	75	65	glycinamide	glycinamide	NOUN
biomedich-729	75	66	1.29	1.29	NUM
biomedich-729	75	67	5	5	NUM
biomedich-729	75	68	hexadecanoic	hexadecanoic	ADJ
biomedich-729	75	69	acid	acid	NOUN
biomedich-729	75	70	,	,	PUNCT
biomedich-729	75	71	methyl	methyl	NOUN
biomedich-729	75	72	ester	ester	NOUN
biomedich-729	75	73	0.80	0.80	NUM
biomedich-729	75	74	oleic	oleic	NOUN
biomedich-729	75	75	acid	acid	PROPN
biomedich-729	75	76	2.89	2.89	NUM
biomedich-729	75	77	6	6	NUM
biomedich-729	75	78	n	n	CCONJ
biomedich-729	75	79	-	-	PUNCT
biomedich-729	75	80	hexadecanoic	hexadecanoic	NOUN
biomedich-729	75	81	acid	acid	NOUN
biomedich-729	75	82	27.45	27.45	NUM
biomedich-729	75	83	methyl	methyl	NOUN
biomedich-729	75	84	9,12	9,12	NUM
biomedich-729	75	85	-	-	PUNCT
biomedich-729	75	86	heptadecadienoate	heptadecadienoate	NOUN
biomedich-729	75	87	1.59	1.59	NUM
biomedich-729	75	88	7	7	NUM
biomedich-729	75	89	hexadecanoic	hexadecanoic	ADJ
biomedich-729	75	90	acid	acid	NOUN
biomedich-729	75	91	,	,	PUNCT
biomedich-729	75	92	ethyl	ethyl	PROPN
biomedich-729	75	93	ester	ester	NOUN
biomedich-729	75	94	6.59	6.59	NUM
biomedich-729	75	95	7	7	NUM
biomedich-729	75	96	-	-	PUNCT
biomedich-729	75	97	pentadecyne	pentadecyne	NOUN
biomedich-729	75	98	1.24	1.24	NUM
biomedich-729	75	99	8	8	NUM
biomedich-729	75	100	cis-9	cis-9	ADV
biomedich-729	75	101	-	-	ADJ
biomedich-729	75	102	tetradecenoic	tetradecenoic	ADJ
biomedich-729	75	103	acid	acid	NOUN
biomedich-729	75	104	,	,	PUNCT
biomedich-729	75	105	propyl	propyl	ADJ
biomedich-729	75	106	ester	ester	NOUN
biomedich-729	75	107	0.80	0.80	NUM
biomedich-729	75	108	2(1h)-naphthalenone	2(1h)-naphthalenone	NUM
biomedich-729	75	109	,	,	PUNCT
biomedich-729	75	110	octahydro-4a	octahydro-4a	NOUN
biomedich-729	75	111	-	-	PUNCT
biomedich-729	75	112	methyl-7-(1	methyl-7-(1	NOUN
biomedich-729	75	113	-	-	PUNCT
biomedich-729	75	114	methylethyl)-	methylethyl)-	NOUN
biomedich-729	75	115	,	,	PUNCT
biomedich-729	75	116	(	(	PUNCT
biomedich-729	75	117	4a.alpha	4a.alpha	X
biomedich-729	75	118	.	.	PROPN
biomedich-729	75	119	,7.beta	,7.beta	PROPN
biomedich-729	75	120	.	.	PUNCT
biomedich-729	75	121	,8a.beta.)6.93	,8a.beta.)6.93	PUNCT
biomedich-729	75	122	9	9	NUM
biomedich-729	75	123	heptadecanoic	heptadecanoic	ADJ
biomedich-729	75	124	acid	acid	NOUN
biomedich-729	75	125	1.69	1.69	NUM
biomedich-729	75	126	(	(	PUNCT
biomedich-729	75	127	3r,4as,8as)-8a	3r,4as,8as)-8a	NOUN
biomedich-729	75	128	-	-	PUNCT
biomedich-729	75	129	methyl-5	methyl-5	NOUN
biomedich-729	75	130	-	-	PUNCT
biomedich-729	75	131	methylene-3-(prop-1	methylene-3-(prop-1	NOUN
biomedich-729	75	132	-	-	PUNCT
biomedich-729	75	133	en-2	en-2	PRON
biomedich-729	75	134	-	-	PUNCT
biomedich-729	75	135	yl)-1,2,3,4,4a,5,6,8a	yl)-1,2,3,4,4a,5,6,8a	ADV
biomedich-729	75	136	-	-	PUNCT
biomedich-729	75	137	octahydronaphthalene	octahydronaphthalene	NOUN
biomedich-729	75	138	4.96	4.96	NUM
biomedich-729	75	139	10	10	NUM
biomedich-729	75	140	z	z	PROPN
biomedich-729	75	141	,	,	PUNCT
biomedich-729	75	142	z-10,12	z-10,12	PROPN
biomedich-729	75	143	-	-	PUNCT
biomedich-729	75	144	hexadecadien-1	hexadecadien-1	PROPN
biomedich-729	75	145	-	-	PUNCT
biomedich-729	75	146	ol	ol	NOUN
biomedich-729	75	147	acetate	acetate	NOUN
biomedich-729	75	148	0.66	0.66	NUM
biomedich-729	75	149	13	13	NUM
biomedich-729	75	150	-	-	PUNCT
biomedich-729	75	151	tetradece-11	tetradece-11	VERB
biomedich-729	75	152	-	-	PUNCT
biomedich-729	75	153	yn-1	yn-1	NOUN
biomedich-729	75	154	-	-	PUNCT
biomedich-729	75	155	ol	ol	ADJ
biomedich-729	75	156	5.34	5.34	NUM
biomedich-729	75	157	11	11	NUM
biomedich-729	75	158	octadecanoic	octadecanoic	ADJ
biomedich-729	75	159	acid	acid	NOUN
biomedich-729	75	160	7.09	7.09	NUM
biomedich-729	75	161	silicic	silicic	NOUN
biomedich-729	75	162	acid	acid	NOUN
biomedich-729	75	163	,	,	PUNCT
biomedich-729	75	164	diethyl	diethyl	NOUN
biomedich-729	75	165	bis(trimethylsilyl	bis(trimethylsilyl	NOUN
biomedich-729	75	166	)	)	PUNCT
biomedich-729	75	167	ester	ester	NOUN
biomedich-729	75	168	2.28	2.28	NUM
biomedich-729	75	169	12	12	NUM
biomedich-729	75	170	octadecanoic	octadecanoic	ADJ
biomedich-729	75	171	acid	acid	NOUN
biomedich-729	75	172	,	,	PUNCT
biomedich-729	75	173	ethyl	ethyl	PROPN
biomedich-729	75	174	ester	ester	NOUN
biomedich-729	75	175	2.09	2.09	NUM
biomedich-729	75	176	2h-3,9a	2h-3,9a	NUM
biomedich-729	75	177	-	-	PUNCT
biomedich-729	75	178	methano-1	methano-1	NOUN
biomedich-729	75	179	-	-	PUNCT
biomedich-729	75	180	benzoxepin	benzoxepin	NOUN
biomedich-729	75	181	,	,	PUNCT
biomedich-729	75	182	octahydro-2,2,5a,9	octahydro-2,2,5a,9	NOUN
biomedich-729	75	183	-	-	PUNCT
biomedich-729	75	184	tetramethyl-	tetramethyl-	NOUN
biomedich-729	75	185	,	,	PUNCT
biomedich-729	75	186	[	[	X
biomedich-729	75	187	3r(3.alpha	3r(3.alpha	NUM
biomedich-729	75	188	.	.	NOUN
biomedich-729	75	189	,5a.alpha	,5a.alpha	PUNCT
biomedich-729	75	190	.	.	PUNCT
biomedich-729	76	1	,9.alpha	,9.alpha	PROPN
biomedich-729	76	2	.	.	PUNCT
biomedich-729	76	3	,9a.alpha	,9a.alpha	PROPN
biomedich-729	76	4	.	.	PUNCT
biomedich-729	76	5	)	)	PUNCT
biomedich-729	77	1	]	]	PUNCT
biomedich-729	77	2	1.56	1.56	NUM
biomedich-729	77	3	13	13	NUM
biomedich-729	77	4	9,12	9,12	NUM
biomedich-729	77	5	-	-	PUNCT
biomedich-729	77	6	octadecadienoic	octadecadienoic	ADJ
biomedich-729	77	7	acid	acid	NOUN
biomedich-729	77	8	(	(	PUNCT
biomedich-729	77	9	z	z	NOUN
biomedich-729	77	10	,	,	PUNCT
biomedich-729	77	11	z)0.76	z)0.76	PROPN
biomedich-729	77	12	cyclododecanol	cyclododecanol	NOUN
biomedich-729	77	13	,	,	PUNCT
biomedich-729	77	14	1	1	NUM
biomedich-729	77	15	-	-	PUNCT
biomedich-729	77	16	aminomethyl1.38	aminomethyl1.38	NOUN
biomedich-729	77	17	14	14	NUM
biomedich-729	77	18	cyclohexene	cyclohexene	NOUN
biomedich-729	77	19	,	,	PUNCT
biomedich-729	77	20	4-(4	4-(4	NUM
biomedich-729	77	21	-	-	PUNCT
biomedich-729	77	22	ethylcyclohexyl)-1	ethylcyclohexyl)-1	NOUN
biomedich-729	77	23	-	-	PUNCT
biomedich-729	77	24	pentyl1.68	pentyl1.68	ADJ
biomedich-729	77	25	2-[1-(3,4	2-[1-(3,4	ADJ
biomedich-729	77	26	-	-	PUNCT
biomedich-729	77	27	dimethyl	dimethyl	NOUN
biomedich-729	77	28	-	-	PUNCT
biomedich-729	77	29	phenyl)-1h	phenyl)-1h	NOUN
biomedich-729	77	30	-	-	PUNCT
biomedich-729	77	31	tetrazol-5	tetrazol-5	NUM
biomedich-729	77	32	-	-	PUNCT
biomedich-729	77	33	ylsulfanyl]-n	ylsulfanyl]-n	NOUN
biomedich-729	77	34	-	-	PUNCT
biomedich-729	77	35	phenethyl	phenethyl	NOUN
biomedich-729	77	36	-	-	PUNCT
biomedich-729	77	37	acetamide	acetamide	NOUN
biomedich-729	77	38	3.66	3.66	NUM
biomedich-729	77	39	15	15	NUM
biomedich-729	77	40	7,10	7,10	NUM
biomedich-729	77	41	-	-	PUNCT
biomedich-729	77	42	octadecadienoic	octadecadienoic	ADJ
biomedich-729	77	43	acid	acid	NOUN
biomedich-729	77	44	,	,	PUNCT
biomedich-729	77	45	methyl	methyl	NOUN
biomedich-729	77	46	ester	ester	NOUN
biomedich-729	77	47	0.59	0.59	NUM
biomedich-729	77	48	2	2	NUM
biomedich-729	77	49	-	-	PUNCT
biomedich-729	77	50	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	77	51	1.76	1.76	NUM
biomedich-729	77	52	16	16	NUM
biomedich-729	77	53	z-8	z-8	NUM
biomedich-729	77	54	-	-	PUNCT
biomedich-729	77	55	methyl-9	methyl-9	NUM
biomedich-729	77	56	-	-	PUNCT
biomedich-729	77	57	tetradecen-1	tetradecen-1	NUM
biomedich-729	77	58	-	-	PUNCT
biomedich-729	77	59	ol	ol	NOUN
biomedich-729	77	60	formate	formate	NOUN
biomedich-729	77	61	0.86	0.86	NUM
biomedich-729	77	62	4	4	NUM
biomedich-729	77	63	-	-	PUNCT
biomedich-729	77	64	methoxy-6	methoxy-6	NUM
biomedich-729	77	65	-	-	PUNCT
biomedich-729	77	66	methyl-5	methyl-5	NOUN
biomedich-729	77	67	-	-	PUNCT
biomedich-729	77	68	nitroisobenzofuran-1,3	nitroisobenzofuran-1,3	NOUN
biomedich-729	77	69	-	-	PUNCT
biomedich-729	77	70	dione	dione	NOUN
biomedich-729	77	71	2.55	2.55	NUM
biomedich-729	77	72	17	17	NUM
biomedich-729	77	73	9,12	9,12	NUM
biomedich-729	77	74	-	-	PUNCT
biomedich-729	77	75	octadecadienoic	octadecadienoic	ADJ
biomedich-729	77	76	acid	acid	NOUN
biomedich-729	77	77	(	(	PUNCT
biomedich-729	77	78	z	z	NOUN
biomedich-729	77	79	,	,	PUNCT
biomedich-729	77	80	z)5.32	z)5.32	X
biomedich-729	77	81	corynan-16	corynan-16	NOUN
biomedich-729	77	82	-	-	PUNCT
biomedich-729	77	83	carboxylic	carboxylic	ADJ
biomedich-729	77	84	acid	acid	NOUN
biomedich-729	77	85	,	,	PUNCT
biomedich-729	77	86	16,17	16,17	ADJ
biomedich-729	77	87	-	-	PUNCT
biomedich-729	77	88	didehydro-9,17	didehydro-9,17	ADJ
biomedich-729	77	89	-	-	PUNCT
biomedich-729	77	90	dimethoxy-	dimethoxy-	NOUN
biomedich-729	77	91	,	,	PUNCT
biomedich-729	77	92	methyl	methyl	NOUN
biomedich-729	77	93	ester	ester	NOUN
biomedich-729	77	94	,	,	PUNCT
biomedich-729	77	95	(	(	PUNCT
biomedich-729	77	96	16e)13.33	16e)13.33	PROPN
biomedich-729	77	97	18	18	NUM
biomedich-729	77	98	ethyl	ethyl	PROPN
biomedich-729	77	99	9.cis	9.cis	PROPN
biomedich-729	77	100	.	.	PROPN
biomedich-729	77	101	,11.trans.-octadecadienoate	,11.trans.-octadecadienoate	PUNCT
biomedich-729	77	102	12.09	12.09	NUM
biomedich-729	77	103	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	77	104	-	-	PUNCT
biomedich-729	77	105	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	77	106	.	.	PUNCT
biomedich-729	77	107	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	77	108	8.21	8.21	NUM
biomedich-729	77	109	19	19	NUM
biomedich-729	77	110	naphthalene	naphthalene	NOUN
biomedich-729	77	111	,	,	PUNCT
biomedich-729	77	112	decahydro-2	decahydro-2	NOUN
biomedich-729	77	113	-	-	PUNCT
biomedich-729	77	114	methyl2.28	methyl2.28	PROPN
biomedich-729	77	115	methanesulfonic	methanesulfonic	PROPN
biomedich-729	77	116	acid	acid	NOUN
biomedich-729	77	117	,	,	PUNCT
biomedich-729	77	118	17	17	NUM
biomedich-729	77	119	-	-	PUNCT
biomedich-729	77	120	cyano-10,13	cyano-10,13	NOUN
biomedich-729	77	121	-	-	PUNCT
biomedich-729	77	122	dimethylhexadecahydrocyclopenta[a]phenanthren-17	dimethylhexadecahydrocyclopenta[a]phenanthren-17	NOUN
biomedich-729	77	123	-	-	PUNCT
biomedich-729	77	124	yl	yl	NOUN
biomedich-729	77	125	ester	ester	NOUN
biomedich-729	77	126	13.68	13.68	NUM
biomedich-729	77	127	20	20	NUM
biomedich-729	77	128	2	2	NUM
biomedich-729	77	129	-	-	PUNCT
biomedich-729	77	130	dodecen-1	dodecen-1	NUM
biomedich-729	77	131	-	-	ADJ
biomedich-729	77	132	yl(-)succinic	yl(-)succinic	ADJ
biomedich-729	77	133	anhydride	anhydride	NOUN
biomedich-729	77	134	3.84	3.84	NUM
biomedich-729	77	135	stigmasterol	stigmasterol	NOUN
biomedich-729	77	136	9.62	9.62	NUM
biomedich-729	77	137	21	21	NUM
biomedich-729	77	138	9	9	NUM
biomedich-729	77	139	-	-	PUNCT
biomedich-729	77	140	tricosene	tricosene	NOUN
biomedich-729	77	141	,	,	PUNCT
biomedich-729	77	142	(	(	PUNCT
biomedich-729	77	143	z)0.88	z)0.88	NUM
biomedich-729	78	1	[	[	PUNCT
biomedich-729	78	2	1,2,4]triazolo[1,5	1,2,4]triazolo[1,5	NUM
biomedich-729	78	3	-	-	PUNCT
biomedich-729	78	4	a]pyrimidine-6	a]pyrimidine-6	NOUN
biomedich-729	78	5	-	-	PUNCT
biomedich-729	78	6	carboxylic	carboxylic	ADJ
biomedich-729	78	7	acid	acid	NOUN
biomedich-729	78	8	,	,	PUNCT
biomedich-729	78	9	4,7	4,7	NUM
biomedich-729	78	10	-	-	PUNCT
biomedich-729	78	11	dihydro-7	dihydro-7	NUM
biomedich-729	78	12	-	-	PUNCT
biomedich-729	78	13	imino-	imino-	NOUN
biomedich-729	78	14	,	,	PUNCT
biomedich-729	78	15	ethyl	ethyl	PROPN
biomedich-729	78	16	ester	ester	NOUN
biomedich-729	78	17	6.11	6.11	NUM
biomedich-729	78	18	22	22	NUM
biomedich-729	78	19	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	78	20	-	-	PUNCT
biomedich-729	78	21	diene	diene	NOUN
biomedich-729	78	22	1.59	1.59	NUM
biomedich-729	78	23	23	23	NUM
biomedich-729	78	24	β	β	NOUN
biomedich-729	78	25	-	-	NOUN
biomedich-729	78	26	sitosterol	sitosterol	VERB
biomedich-729	78	27	2.69	2.69	NUM
biomedich-729	78	28	24	24	NUM
biomedich-729	78	29	docosanoic	docosanoic	ADJ
biomedich-729	78	30	acid	acid	NOUN
biomedich-729	78	31	2.75	2.75	NUM
biomedich-729	78	32	25	25	NUM
biomedich-729	78	33	3-(2	3-(2	PROPN
biomedich-729	78	34	-	-	PUNCT
biomedich-729	78	35	methoxymethoxyethylidene)-2,2	methoxymethoxyethylidene)-2,2	NOUN
biomedich-729	78	36	dimethylbicyclo[2.2.1]heptane	dimethylbicyclo[2.2.1]heptane	PROPN
biomedich-729	78	37	0.79	0.79	NUM
biomedich-729	78	38	26	26	NUM
biomedich-729	78	39	1-(4	1-(4	NUM
biomedich-729	78	40	-	-	PUNCT
biomedich-729	78	41	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	78	42	-	-	PUNCT
biomedich-729	78	43	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	78	44	0.92	0.92	NUM
biomedich-729	78	45	27	27	NUM
biomedich-729	78	46	γ	γ	NOUN
biomedich-729	78	47	-	-	NOUN
biomedich-729	78	48	sitosterol	sitosterol	NOUN
biomedich-729	78	49	6.13	6.13	NUM
biomedich-729	78	50	28	28	NUM
biomedich-729	78	51	stigmasterol	stigmasterol	NOUN
biomedich-729	78	52	3.68	3.68	NUM
biomedich-729	78	53	29	29	NUM
biomedich-729	78	54	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	78	55	-	-	PUNCT
biomedich-729	78	56	diene	diene	NOUN
biomedich-729	78	57	2.33	2.33	NUM
biomedich-729	78	58	b	b	SYM
biomedich-729	78	59	io	io	ADP
biomedich-729	78	60	lo	lo	PROPN
biomedich-729	78	61	g	g	PROPN
biomedich-729	78	62	y	y	PROPN
biomedich-729	78	63	,	,	PUNCT
biomedich-729	78	64	m	m	VERB
biomedich-729	78	65	ed	ed	NOUN
biomedich-729	78	66	ic	ic	PROPN
biomedich-729	78	67	in	in	ADP
biomedich-729	78	68	e	e	PROPN
biomedich-729	78	69	,	,	PUNCT
biomedich-729	78	70	&	&	CCONJ
biomedich-729	78	71	n	n	PROPN
biomedich-729	78	72	atu	atu	X
biomedich-729	78	73	ral	ral	ADJ
biomedich-729	78	74	pro	pro	X
biomedich-729	79	1	d	d	X
biomedich-729	79	2	u	u	X
biomedich-729	80	1	c	c	NOUN
biomedich-729	80	2	t	t	NOUN
biomedich-729	80	3	c	c	NOUN
biomedich-729	81	1	h	h	NOUN
biomedich-729	81	2	em	em	PRON
biomedich-729	81	3	istry	istry	NOUN
biomedich-729	81	4	1	1	NUM
biomedich-729	81	5	4	4	NUM
biomedich-729	81	6	(	(	PUNCT
biomedich-729	81	7	1	1	NUM
biomedich-729	81	8	)	)	PUNCT
biomedich-729	81	9	,	,	PUNCT
biomedich-729	81	10	2	2	NUM
biomedich-729	81	11	0	0	NUM
biomedich-729	81	12	2	2	NUM
biomedich-729	81	13	5	5	NUM
biomedich-729	81	14	:	:	SYM
biomedich-729	81	15	369	369	NUM
biomedich-729	81	16	-379	-379	NUM
biomedich-729	81	17	372	372	NUM
biomedich-729	81	18	ajayi	ajayi	NOUN
biomedich-729	81	19	et	et	PROPN
biomedich-729	81	20	al	al	PROPN
biomedich-729	81	21	.	.	PROPN
biomedich-729	81	22	–	–	PUNCT
biomedich-729	81	23	toxicity	toxicity	NOUN
biomedich-729	81	24	prediction	prediction	NOUN
biomedich-729	81	25	of	of	ADP
biomedich-729	81	26	cola	cola	PROPN
biomedich-729	81	27	rostrata	rostrata	PROPN
biomedich-729	81	28	epicarp	epicarp	ADJ
biomedich-729	81	29	373	373	NUM
biomedich-729	81	30	table	table	NOUN
biomedich-729	81	31	2	2	NUM
biomedich-729	81	32	.	.	PUNCT
biomedich-729	82	1	numbers	number	NOUN
biomedich-729	82	2	of	of	ADP
biomedich-729	82	3	cola	cola	NOUN
biomedich-729	82	4	rostrata	rostrata	NOUN
biomedich-729	82	5	extract	extract	VERB
biomedich-729	82	6	components	component	NOUN
biomedich-729	82	7	with	with	ADP
biomedich-729	82	8	various	various	ADJ
biomedich-729	82	9	degrees	degree	NOUN
biomedich-729	82	10	of	of	ADP
biomedich-729	82	11	inhibitory	inhibitory	ADJ
biomedich-729	82	12	binging	binging	NOUN
biomedich-729	82	13	to	to	ADP
biomedich-729	82	14	members	member	NOUN
biomedich-729	82	15	of	of	ADP
biomedich-729	82	16	cytochrome	cytochrome	ADJ
biomedich-729	82	17	p450	p450	ADJ
biomedich-729	82	18	protein	protein	NOUN
biomedich-729	82	19	family	family	NOUN
biomedich-729	82	20	.	.	PUNCT
biomedich-729	83	1	cyp	cyp	ADJ
biomedich-729	83	2	family	family	NOUN
biomedich-729	83	3	no	no	DET
biomedich-729	83	4	binding	bind	VERB
biomedich-729	83	5	very	very	ADV
biomedich-729	83	6	low	low	ADJ
biomedich-729	83	7	low	low	ADJ
biomedich-729	83	8	medium	medium	ADJ
biomedich-729	83	9	high	high	ADJ
biomedich-729	83	10	very	very	ADV
biomedich-729	83	11	high	high	ADJ
biomedich-729	84	1	np	np	INTJ
biomedich-729	84	2	p	p	X
biomedich-729	85	1	np	np	INTJ
biomedich-729	85	2	p	p	X
biomedich-729	85	3	np	np	INTJ
biomedich-729	85	4	p	p	X
biomedich-729	85	5	np	np	INTJ
biomedich-729	85	6	p	p	X
biomedich-729	85	7	np	np	INTJ
biomedich-729	85	8	p	p	X
biomedich-729	85	9	np	np	INTJ
biomedich-729	85	10	p	p	PROPN
biomedich-729	85	11	cyp1a2	cyp1a2	PROPN
biomedich-729	85	12	6	6	NUM
biomedich-729	85	13	3	3	NUM
biomedich-729	85	14	11	11	NUM
biomedich-729	85	15	4	4	NUM
biomedich-729	85	16	0	0	NUM
biomedich-729	85	17	1	1	NUM
biomedich-729	85	18	3	3	NUM
biomedich-729	85	19	6	6	NUM
biomedich-729	85	20	3	3	NUM
biomedich-729	85	21	2	2	NUM
biomedich-729	85	22	5	5	NUM
biomedich-729	85	23	5	5	NUM
biomedich-729	85	24	cyp2c19	cyp2c19	NOUN
biomedich-729	85	25	7	7	NUM
biomedich-729	85	26	3	3	NUM
biomedich-729	85	27	9	9	NUM
biomedich-729	85	28	9	9	NUM
biomedich-729	85	29	5	5	NUM
biomedich-729	85	30	1	1	NUM
biomedich-729	85	31	5	5	NUM
biomedich-729	85	32	3	3	NUM
biomedich-729	85	33	2	2	NUM
biomedich-729	85	34	2	2	NUM
biomedich-729	85	35	0	0	NUM
biomedich-729	85	36	3	3	NUM
biomedich-729	85	37	cyp2c9	cyp2c9	NOUN
biomedich-729	85	38	6	6	NUM
biomedich-729	85	39	1	1	NUM
biomedich-729	85	40	13	13	NUM
biomedich-729	85	41	12	12	NUM
biomedich-729	85	42	5	5	NUM
biomedich-729	85	43	3	3	NUM
biomedich-729	85	44	3	3	NUM
biomedich-729	85	45	3	3	NUM
biomedich-729	85	46	1	1	NUM
biomedich-729	85	47	1	1	NUM
biomedich-729	85	48	0	0	NUM
biomedich-729	85	49	1	1	NUM
biomedich-729	85	50	cyp2d6	cyp2d6	NOUN
biomedich-729	85	51	17	17	NUM
biomedich-729	85	52	13	13	NUM
biomedich-729	85	53	8	8	NUM
biomedich-729	85	54	4	4	NUM
biomedich-729	85	55	1	1	NUM
biomedich-729	85	56	2	2	NUM
biomedich-729	85	57	2	2	NUM
biomedich-729	85	58	0	0	NUM
biomedich-729	85	59	0	0	NUM
biomedich-729	85	60	1	1	NUM
biomedich-729	85	61	0	0	NUM
biomedich-729	85	62	1	1	NUM
biomedich-729	85	63	cyp2a4	cyp2a4	NOUN
biomedich-729	85	64	10	10	NUM
biomedich-729	85	65	4	4	NUM
biomedich-729	85	66	4	4	NUM
biomedich-729	85	67	7	7	NUM
biomedich-729	85	68	8	8	NUM
biomedich-729	85	69	4	4	NUM
biomedich-729	85	70	4	4	NUM
biomedich-729	85	71	2	2	NUM
biomedich-729	85	72	2	2	NUM
biomedich-729	85	73	3	3	NUM
biomedich-729	85	74	0	0	NUM
biomedich-729	85	75	1	1	NUM
biomedich-729	85	76	cyp	cyp	ADJ
biomedich-729	85	77	:	:	PUNCT
biomedich-729	85	78	cytochrome	cytochrome	NOUN
biomedich-729	85	79	p450	p450	NUM
biomedich-729	85	80	;	;	PUNCT
biomedich-729	85	81	np	np	X
biomedich-729	85	82	:	:	PUNCT
biomedich-729	85	83	non	non	ADJ
biomedich-729	85	84	-	-	ADJ
biomedich-729	85	85	polar	polar	ADJ
biomedich-729	85	86	fraction	fraction	NOUN
biomedich-729	85	87	;	;	PUNCT
biomedich-729	86	1	p	p	X
biomedich-729	86	2	:	:	PUNCT
biomedich-729	86	3	polar	polar	ADJ
biomedich-729	86	4	fraction	fraction	NOUN
biomedich-729	86	5	.	.	PUNCT
biomedich-729	87	1	probability	probability	NOUN
biomedich-729	87	2	of	of	ADP
biomedich-729	87	3	inhibition	inhibition	NOUN
biomedich-729	87	4	:	:	PUNCT
biomedich-729	87	5	no	no	DET
biomedich-729	87	6	binding	bind	VERB
biomedich-729	87	7	(	(	PUNCT
biomedich-729	87	8	0–10	0–10	NOUN
biomedich-729	87	9	%	%	NOUN
biomedich-729	87	10	)	)	PUNCT
biomedich-729	87	11	;	;	PUNCT
biomedich-729	87	12	very	very	ADV
biomedich-729	87	13	low	low	ADJ
biomedich-729	87	14	(	(	PUNCT
biomedich-729	87	15	10–30	10–30	NUM
biomedich-729	87	16	%	%	NOUN
biomedich-729	87	17	)	)	PUNCT
biomedich-729	87	18	;	;	PUNCT
biomedich-729	87	19	low	low	ADJ
biomedich-729	87	20	(	(	PUNCT
biomedich-729	87	21	30–50	30–50	NUM
biomedich-729	87	22	%	%	NOUN
biomedich-729	87	23	)	)	PUNCT
biomedich-729	87	24	;	;	PUNCT
biomedich-729	87	25	medium	medium	NOUN
biomedich-729	87	26	(	(	PUNCT
biomedich-729	87	27	50–70	50–70	NUM
biomedich-729	87	28	%	%	NOUN
biomedich-729	87	29	)	)	PUNCT
biomedich-729	87	30	;	;	PUNCT
biomedich-729	87	31	high	high	ADJ
biomedich-729	87	32	(	(	PUNCT
biomedich-729	87	33	70–90	70–90	NUM
biomedich-729	87	34	%	%	NOUN
biomedich-729	87	35	)	)	PUNCT
biomedich-729	87	36	and	and	CCONJ
biomedich-729	87	37	very	very	ADV
biomedich-729	87	38	high	high	ADJ
biomedich-729	87	39	(	(	PUNCT
biomedich-729	87	40	90–100	90–100	NUM
biomedich-729	87	41	%	%	NOUN
biomedich-729	87	42	)	)	PUNCT
biomedich-729	87	43	.	.	PUNCT
biomedich-729	88	1	toxicity	toxicity	NOUN
biomedich-729	88	2	of	of	ADP
biomedich-729	88	3	the	the	DET
biomedich-729	88	4	components	component	NOUN
biomedich-729	88	5	of	of	ADP
biomedich-729	88	6	c.	c.	PROPN
biomedich-729	88	7	rostrata	rostrata	PROPN
biomedich-729	88	8	extract	extract	VERB
biomedich-729	88	9	fractions	fraction	NOUN
biomedich-729	88	10	the	the	DET
biomedich-729	88	11	predicted	predict	VERB
biomedich-729	88	12	toxic	toxic	ADJ
biomedich-729	88	13	effects	effect	NOUN
biomedich-729	88	14	of	of	ADP
biomedich-729	88	15	the	the	DET
biomedich-729	88	16	components	component	NOUN
biomedich-729	88	17	of	of	ADP
biomedich-729	88	18	the	the	DET
biomedich-729	88	19	polar	polar	ADJ
biomedich-729	88	20	and	and	CCONJ
biomedich-729	88	21	non	non	ADJ
biomedich-729	88	22	-	-	ADJ
biomedich-729	88	23	polar	polar	ADJ
biomedich-729	88	24	components	component	NOUN
biomedich-729	88	25	of	of	ADP
biomedich-729	88	26	c.	c.	PROPN
biomedich-729	88	27	rostrata	rostrata	PROPN
biomedich-729	88	28	epicarp	epicarp	ADJ
biomedich-729	88	29	is	be	AUX
biomedich-729	88	30	mainly	mainly	ADV
biomedich-729	88	31	drug	drug	NOUN
biomedich-729	88	32	-	-	PUNCT
biomedich-729	88	33	induced	induce	VERB
biomedich-729	88	34	liver	liver	NOUN
biomedich-729	88	35	injury	injury	NOUN
biomedich-729	88	36	,	,	PUNCT
biomedich-729	88	37	followed	follow	VERB
biomedich-729	88	38	by	by	ADP
biomedich-729	88	39	hepatotoxicity	hepatotoxicity	NOUN
biomedich-729	88	40	and	and	CCONJ
biomedich-729	88	41	ability	ability	NOUN
biomedich-729	88	42	to	to	PART
biomedich-729	88	43	block	block	VERB
biomedich-729	88	44	the	the	DET
biomedich-729	88	45	herg	herg	PROPN
biomedich-729	88	46	channels	channel	NOUN
biomedich-729	88	47	(	(	PUNCT
biomedich-729	88	48	table	table	NOUN
biomedich-729	88	49	3	3	NUM
biomedich-729	88	50	)	)	PUNCT
biomedich-729	88	51	.	.	PUNCT
biomedich-729	89	1	two	two	NUM
biomedich-729	89	2	compounds	compound	NOUN
biomedich-729	89	3	,	,	PUNCT
biomedich-729	89	4	one	one	NUM
biomedich-729	89	5	in	in	ADP
biomedich-729	89	6	each	each	PRON
biomedich-729	89	7	of	of	ADP
biomedich-729	89	8	the	the	DET
biomedich-729	89	9	fractions	fraction	NOUN
biomedich-729	89	10	,	,	PUNCT
biomedich-729	89	11	have	have	VERB
biomedich-729	89	12	90	90	NUM
biomedich-729	89	13	%	%	NOUN
biomedich-729	89	14	to	to	PART
biomedich-729	89	15	100	100	NUM
biomedich-729	89	16	%	%	NOUN
biomedich-729	89	17	likelihood	likelihood	NOUN
biomedich-729	89	18	of	of	ADP
biomedich-729	89	19	causing	cause	VERB
biomedich-729	89	20	liver	liver	NOUN
biomedich-729	89	21	damage	damage	NOUN
biomedich-729	89	22	,	,	PUNCT
biomedich-729	89	23	and	and	CCONJ
biomedich-729	89	24	these	these	DET
biomedich-729	89	25	compounds	compound	NOUN
biomedich-729	89	26	are	be	AUX
biomedich-729	89	27	2	2	NUM
biomedich-729	89	28	-	-	NOUN
biomedich-729	89	29	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	89	30	and	and	CCONJ
biomedich-729	89	31	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	89	32	-	-	PUNCT
biomedich-729	89	33	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	89	34	,	,	PUNCT
biomedich-729	89	35	in	in	ADP
biomedich-729	89	36	the	the	DET
biomedich-729	89	37	polar	polar	ADJ
biomedich-729	89	38	and	and	CCONJ
biomedich-729	89	39	non	non	ADJ
biomedich-729	89	40	-	-	ADJ
biomedich-729	89	41	polar	polar	ADJ
biomedich-729	89	42	fractions	fraction	NOUN
biomedich-729	89	43	,	,	PUNCT
biomedich-729	89	44	respectively	respectively	ADV
biomedich-729	89	45	.	.	PUNCT
biomedich-729	90	1	silicic	silicic	NOUN
biomedich-729	90	2	acid	acid	NOUN
biomedich-729	90	3	,	,	PUNCT
biomedich-729	90	4	diethyl	diethyl	NOUN
biomedich-729	90	5	bis(trimethylsilyl	bis(trimethylsilyl	NOUN
biomedich-729	90	6	)	)	PUNCT
biomedich-729	90	7	ester	ester	NOUN
biomedich-729	90	8	which	which	PRON
biomedich-729	90	9	is	be	AUX
biomedich-729	90	10	present	present	ADJ
biomedich-729	90	11	in	in	ADP
biomedich-729	90	12	the	the	DET
biomedich-729	90	13	polar	polar	ADJ
biomedich-729	90	14	fraction	fraction	NOUN
biomedich-729	90	15	,	,	PUNCT
biomedich-729	90	16	also	also	ADV
biomedich-729	90	17	has	have	VERB
biomedich-729	90	18	70	70	NUM
biomedich-729	90	19	%	%	NOUN
biomedich-729	90	20	to	to	PART
biomedich-729	90	21	90	90	NUM
biomedich-729	90	22	%	%	NOUN
biomedich-729	90	23	likelihood	likelihood	NOUN
biomedich-729	90	24	of	of	ADP
biomedich-729	90	25	causing	cause	VERB
biomedich-729	90	26	injury	injury	NOUN
biomedich-729	90	27	to	to	ADP
biomedich-729	90	28	the	the	DET
biomedich-729	90	29	liver	liver	NOUN
biomedich-729	90	30	.	.	PUNCT
biomedich-729	91	1	in	in	ADP
biomedich-729	91	2	the	the	DET
biomedich-729	91	3	non	non	ADJ
biomedich-729	91	4	-	-	ADJ
biomedich-729	91	5	polar	polar	ADJ
biomedich-729	91	6	fraction	fraction	NOUN
biomedich-729	91	7	,	,	PUNCT
biomedich-729	91	8	ethyl	ethyl	PROPN
biomedich-729	91	9	9.cis	9.cis	PROPN
biomedich-729	91	10	.	.	PROPN
biomedich-729	91	11	,11.trans.-octadecadienoate	,11.trans.-octadecadienoate	PUNCT
biomedich-729	91	12	and	and	CCONJ
biomedich-729	91	13	β	β	X
biomedich-729	91	14	-	-	NOUN
biomedich-729	91	15	sitosterol	sitosterol	NOUN
biomedich-729	91	16	have	have	VERB
biomedich-729	91	17	high	high	ADJ
biomedich-729	91	18	likelihood	likelihood	NOUN
biomedich-729	91	19	of	of	ADP
biomedich-729	91	20	blocking	block	VERB
biomedich-729	91	21	herg	herg	PROPN
biomedich-729	91	22	channels	channel	NOUN
biomedich-729	91	23	.	.	PUNCT
biomedich-729	92	1	hepatotoxicity	hepatotoxicity	NOUN
biomedich-729	92	2	could	could	AUX
biomedich-729	92	3	be	be	AUX
biomedich-729	92	4	caused	cause	VERB
biomedich-729	92	5	by	by	ADP
biomedich-729	92	6	two	two	NUM
biomedich-729	92	7	compounds	compound	NOUN
biomedich-729	92	8	in	in	ADP
biomedich-729	92	9	the	the	DET
biomedich-729	92	10	polar	polar	ADJ
biomedich-729	92	11	fraction	fraction	NOUN
biomedich-729	92	12	:	:	PUNCT
biomedich-729	92	13	methanesulfonic	methanesulfonic	ADJ
biomedich-729	92	14	acid	acid	NOUN
biomedich-729	92	15	,	,	PUNCT
biomedich-729	92	16	17	17	NUM
biomedich-729	92	17	-	-	PUNCT
biomedich-729	92	18	cyano-10,13dimethylhexadecahydrocyclopenta[a]phenanthren-17	cyano-10,13dimethylhexadecahydrocyclopenta[a]phenanthren-17	NOUN
biomedich-729	92	19	-	-	PUNCT
biomedich-729	92	20	yl	yl	NOUN
biomedich-729	92	21	ester	ester	NOUN
biomedich-729	92	22	and	and	CCONJ
biomedich-729	92	23	[	[	X
biomedich-729	92	24	1,2,4]triazolo[1,5	1,2,4]triazolo[1,5	NUM
biomedich-729	92	25	-	-	PUNCT
biomedich-729	92	26	a]pyrimidine-6	a]pyrimidine-6	NOUN
biomedich-729	92	27	-	-	PUNCT
biomedich-729	92	28	carboxylic	carboxylic	ADJ
biomedich-729	92	29	acid	acid	NOUN
biomedich-729	92	30	,	,	PUNCT
biomedich-729	92	31	4,7	4,7	NUM
biomedich-729	92	32	-	-	PUNCT
biomedich-729	92	33	dihydro-7	dihydro-7	NUM
biomedich-729	92	34	-	-	PUNCT
biomedich-729	92	35	imino-	imino-	NOUN
biomedich-729	92	36	,	,	PUNCT
biomedich-729	92	37	ethyl	ethyl	PROPN
biomedich-729	92	38	ester	ester	NOUN
biomedich-729	92	39	.	.	PUNCT
biomedich-729	93	1	other	other	ADJ
biomedich-729	93	2	predicted	predict	VERB
biomedich-729	93	3	negative	negative	ADJ
biomedich-729	93	4	effects	effect	NOUN
biomedich-729	93	5	of	of	ADP
biomedich-729	93	6	the	the	DET
biomedich-729	93	7	components	component	NOUN
biomedich-729	93	8	include	include	VERB
biomedich-729	93	9	the	the	DET
biomedich-729	93	10	likelihood	likelihood	NOUN
biomedich-729	93	11	of	of	ADP
biomedich-729	93	12	3-(2	3-(2	PROPN
biomedich-729	93	13	-	-	PUNCT
biomedich-729	93	14	methoxymethoxyethylidene)-2,2	methoxymethoxyethylidene)-2,2	NOUN
biomedich-729	93	15	dimethylbicyclo[2.2.1]heptane	dimethylbicyclo[2.2.1]heptane	PROPN
biomedich-729	93	16	and	and	CCONJ
biomedich-729	93	17	corynan-16carboxylic	corynan-16carboxylic	PROPN
biomedich-729	93	18	acid	acid	ADJ
biomedich-729	93	19	,	,	PUNCT
biomedich-729	93	20	16,17	16,17	ADJ
biomedich-729	93	21	-	-	PUNCT
biomedich-729	93	22	didehydro-9,17	didehydro-9,17	ADJ
biomedich-729	93	23	-	-	PUNCT
biomedich-729	93	24	dimethoxy-	dimethoxy-	NOUN
biomedich-729	93	25	,	,	PUNCT
biomedich-729	93	26	methyl	methyl	NOUN
biomedich-729	93	27	ester	ester	NOUN
biomedich-729	93	28	,	,	PUNCT
biomedich-729	93	29	(	(	PUNCT
biomedich-729	93	30	16e)-inducing	16e)-inducing	NUM
biomedich-729	93	31	carcinogenesis	carcinogenesis	NOUN
biomedich-729	93	32	,	,	PUNCT
biomedich-729	93	33	and	and	CCONJ
biomedich-729	93	34	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	93	35	-	-	PUNCT
biomedich-729	93	36	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	93	37	with	with	ADP
biomedich-729	93	38	a	a	DET
biomedich-729	93	39	very	very	ADV
biomedich-729	93	40	high	high	ADJ
biomedich-729	93	41	potential	potential	NOUN
biomedich-729	93	42	to	to	PART
biomedich-729	93	43	induce	induce	VERB
biomedich-729	93	44	mutation	mutation	NOUN
biomedich-729	93	45	.	.	PUNCT
biomedich-729	94	1	table	table	NOUN
biomedich-729	94	2	3	3	NUM
biomedich-729	94	3	.	.	PUNCT
biomedich-729	95	1	numbers	number	NOUN
biomedich-729	95	2	of	of	ADP
biomedich-729	95	3	cola	cola	NOUN
biomedich-729	95	4	rostrata	rostrata	NOUN
biomedich-729	95	5	extract	extract	VERB
biomedich-729	95	6	components	component	NOUN
biomedich-729	95	7	with	with	ADP
biomedich-729	95	8	various	various	ADJ
biomedich-729	95	9	degrees	degree	NOUN
biomedich-729	95	10	of	of	ADP
biomedich-729	95	11	end	end	NOUN
biomedich-729	95	12	-	-	PUNCT
biomedich-729	95	13	point	point	NOUN
biomedich-729	95	14	toxicities	toxicity	NOUN
biomedich-729	95	15	.	.	PUNCT
biomedich-729	96	1	end	end	NOUN
biomedich-729	96	2	-	-	PUNCT
biomedich-729	96	3	point	point	NOUN
biomedich-729	96	4	toxicities	toxicity	NOUN
biomedich-729	96	5	nontoxic	nontoxic	ADJ
biomedich-729	96	6	very	very	ADV
biomedich-729	96	7	low	low	ADJ
biomedich-729	96	8	low	low	ADJ
biomedich-729	96	9	medium	medium	ADJ
biomedich-729	96	10	high	high	ADJ
biomedich-729	96	11	very	very	ADV
biomedich-729	96	12	high	high	ADJ
biomedich-729	96	13	np	np	INTJ
biomedich-729	96	14	p	p	X
biomedich-729	97	1	np	np	INTJ
biomedich-729	97	2	p	p	X
biomedich-729	97	3	np	np	INTJ
biomedich-729	97	4	p	p	X
biomedich-729	97	5	np	np	INTJ
biomedich-729	97	6	p	p	X
biomedich-729	97	7	np	np	INTJ
biomedich-729	97	8	p	p	NOUN
biomedich-729	98	1	np	np	INTJ
biomedich-729	98	2	p	p	NOUN
biomedich-729	98	3	herg	herg	PROPN
biomedich-729	98	4	blockers	blocker	NOUN
biomedich-729	98	5	18	18	NUM
biomedich-729	98	6	13	13	NUM
biomedich-729	98	7	6	6	NUM
biomedich-729	98	8	7	7	NUM
biomedich-729	98	9	1	1	NUM
biomedich-729	98	10	0	0	NUM
biomedich-729	98	11	1	1	NUM
biomedich-729	98	12	0	0	NUM
biomedich-729	98	13	2	2	NUM
biomedich-729	98	14	0	0	NUM
biomedich-729	98	15	0	0	NUM
biomedich-729	98	16	1	1	NUM
biomedich-729	98	17	hepatotoxic	hepatotoxic	NOUN
biomedich-729	98	18	20	20	NUM
biomedich-729	98	19	9	9	NUM
biomedich-729	98	20	7	7	NUM
biomedich-729	98	21	8	8	NUM
biomedich-729	98	22	1	1	NUM
biomedich-729	98	23	2	2	NUM
biomedich-729	98	24	0	0	NUM
biomedich-729	98	25	0	0	NUM
biomedich-729	98	26	0	0	NUM
biomedich-729	98	27	2	2	NUM
biomedich-729	98	28	0	0	NUM
biomedich-729	98	29	0	0	NUM
biomedich-729	98	30	dili	dili	NOUN
biomedich-729	98	31	17	17	NUM
biomedich-729	98	32	11	11	NUM
biomedich-729	98	33	6	6	NUM
biomedich-729	98	34	3	3	NUM
biomedich-729	98	35	2	2	NUM
biomedich-729	98	36	2	2	NUM
biomedich-729	98	37	2	2	NUM
biomedich-729	98	38	2	2	NUM
biomedich-729	98	39	0	0	NUM
biomedich-729	98	40	2	2	NUM
biomedich-729	98	41	1	1	NUM
biomedich-729	98	42	1	1	NUM
biomedich-729	98	43	mutagenicity	mutagenicity	NOUN
biomedich-729	98	44	27	27	NUM
biomedich-729	98	45	17	17	NUM
biomedich-729	98	46	0	0	NUM
biomedich-729	98	47	1	1	NUM
biomedich-729	98	48	0	0	NUM
biomedich-729	98	49	0	0	NUM
biomedich-729	98	50	0	0	NUM
biomedich-729	98	51	2	2	NUM
biomedich-729	98	52	0	0	NUM
biomedich-729	98	53	1	1	NUM
biomedich-729	98	54	1	1	NUM
biomedich-729	98	55	0	0	NUM
biomedich-729	98	56	roat	roat	NOUN
biomedich-729	98	57	26	26	NUM
biomedich-729	98	58	14	14	NUM
biomedich-729	98	59	2	2	NUM
biomedich-729	98	60	2	2	NUM
biomedich-729	98	61	0	0	NUM
biomedich-729	98	62	2	2	NUM
biomedich-729	98	63	0	0	NUM
biomedich-729	98	64	1	1	NUM
biomedich-729	98	65	0	0	NUM
biomedich-729	98	66	1	1	NUM
biomedich-729	98	67	0	0	NUM
biomedich-729	98	68	1	1	NUM
biomedich-729	98	69	fdamdd	fdamdd	NOUN
biomedich-729	98	70	18	18	NUM
biomedich-729	98	71	9	9	NUM
biomedich-729	98	72	1	1	NUM
biomedich-729	98	73	6	6	NUM
biomedich-729	98	74	4	4	NUM
biomedich-729	98	75	1	1	NUM
biomedich-729	98	76	4	4	NUM
biomedich-729	98	77	1	1	NUM
biomedich-729	98	78	1	1	NUM
biomedich-729	98	79	1	1	NUM
biomedich-729	98	80	0	0	NUM
biomedich-729	98	81	3	3	NUM
biomedich-729	98	82	carcinogenicity	carcinogenicity	NOUN
biomedich-729	98	83	14	14	NUM
biomedich-729	98	84	10	10	NUM
biomedich-729	98	85	9	9	NUM
biomedich-729	98	86	3	3	NUM
biomedich-729	98	87	2	2	NUM
biomedich-729	98	88	0	0	NUM
biomedich-729	98	89	1	1	NUM
biomedich-729	98	90	5	5	NUM
biomedich-729	98	91	1	1	NUM
biomedich-729	98	92	2	2	NUM
biomedich-729	98	93	1	1	NUM
biomedich-729	98	94	1	1	NUM
biomedich-729	98	95	herg	herg	PROPN
biomedich-729	98	96	:	:	PUNCT
biomedich-729	98	97	human	human	ADJ
biomedich-729	98	98	ether	ether	NOUN
biomedich-729	98	99	-	-	PUNCT
biomedich-729	98	100	a	a	DET
biomedich-729	98	101	-	-	PUNCT
biomedich-729	98	102	go	go	NOUN
biomedich-729	98	103	-	-	PUNCT
biomedich-729	98	104	go	go	NOUN
biomedich-729	98	105	-	-	PUNCT
biomedich-729	98	106	related	relate	VERB
biomedich-729	98	107	gene	gene	NOUN
biomedich-729	98	108	;	;	PUNCT
biomedich-729	98	109	dili	dili	PROPN
biomedich-729	98	110	:	:	PUNCT
biomedich-729	98	111	drug	drug	NOUN
biomedich-729	98	112	-	-	PUNCT
biomedich-729	98	113	induced	induce	VERB
biomedich-729	98	114	liver	liver	NOUN
biomedich-729	98	115	injury	injury	NOUN
biomedich-729	98	116	;	;	PUNCT
biomedich-729	98	117	roat	roat	NOUN
biomedich-729	98	118	:	:	PUNCT
biomedich-729	98	119	rat	rat	NOUN
biomedich-729	98	120	oral	oral	ADJ
biomedich-729	98	121	acute	acute	NOUN
biomedich-729	98	122	toxicity	toxicity	NOUN
biomedich-729	98	123	;	;	PUNCT
biomedich-729	98	124	fdamdd	fdamdd	ADJ
biomedich-729	98	125	:	:	PUNCT
biomedich-729	98	126	federal	federal	ADJ
biomedich-729	98	127	drug	drug	PROPN
biomedich-729	98	128	administration	administration	PROPN
biomedich-729	98	129	maximum	maximum	PROPN
biomedich-729	98	130	(	(	PUNCT
biomedich-729	98	131	recommended	recommend	VERB
biomedich-729	98	132	)	)	PUNCT
biomedich-729	98	133	daily	daily	ADJ
biomedich-729	98	134	dose	dose	PROPN
biomedich-729	98	135	;	;	PUNCT
biomedich-729	98	136	np	np	X
biomedich-729	98	137	:	:	PUNCT
biomedich-729	98	138	non	non	ADJ
biomedich-729	98	139	-	-	ADJ
biomedich-729	98	140	polar	polar	ADJ
biomedich-729	98	141	extract	extract	NOUN
biomedich-729	98	142	fraction	fraction	NOUN
biomedich-729	98	143	;	;	PUNCT
biomedich-729	98	144	and	and	CCONJ
biomedich-729	98	145	p	p	X
biomedich-729	98	146	:	:	PUNCT
biomedich-729	98	147	polar	polar	ADJ
biomedich-729	98	148	extract	extract	NOUN
biomedich-729	98	149	fraction	fraction	NOUN
biomedich-729	98	150	.	.	PUNCT
biomedich-729	99	1	probability	probability	NOUN
biomedich-729	99	2	of	of	ADP
biomedich-729	99	3	toxicity	toxicity	NOUN
biomedich-729	99	4	:	:	PUNCT
biomedich-729	99	5	nontoxic	nontoxic	ADJ
biomedich-729	99	6	(	(	PUNCT
biomedich-729	99	7	0–10	0–10	NOUN
biomedich-729	99	8	%	%	NOUN
biomedich-729	99	9	)	)	PUNCT
biomedich-729	99	10	;	;	PUNCT
biomedich-729	99	11	very	very	ADV
biomedich-729	99	12	low	low	ADJ
biomedich-729	99	13	(	(	PUNCT
biomedich-729	99	14	10–30	10–30	NUM
biomedich-729	99	15	%	%	NOUN
biomedich-729	99	16	)	)	PUNCT
biomedich-729	99	17	;	;	PUNCT
biomedich-729	99	18	low	low	ADJ
biomedich-729	99	19	(	(	PUNCT
biomedich-729	99	20	30–50	30–50	NUM
biomedich-729	99	21	%	%	NOUN
biomedich-729	99	22	)	)	PUNCT
biomedich-729	99	23	;	;	PUNCT
biomedich-729	99	24	medium	medium	NOUN
biomedich-729	99	25	(	(	PUNCT
biomedich-729	99	26	50–70	50–70	NUM
biomedich-729	99	27	%	%	NOUN
biomedich-729	99	28	)	)	PUNCT
biomedich-729	99	29	;	;	PUNCT
biomedich-729	99	30	high	high	ADJ
biomedich-729	99	31	(	(	PUNCT
biomedich-729	99	32	70–90	70–90	NUM
biomedich-729	99	33	%	%	NOUN
biomedich-729	99	34	)	)	PUNCT
biomedich-729	99	35	and	and	CCONJ
biomedich-729	99	36	very	very	ADV
biomedich-729	99	37	high	high	ADJ
biomedich-729	99	38	(	(	PUNCT
biomedich-729	99	39	90–100	90–100	NUM
biomedich-729	99	40	%	%	NOUN
biomedich-729	99	41	)	)	PUNCT
biomedich-729	99	42	.	.	PUNCT
biomedich-729	100	1	the	the	DET
biomedich-729	100	2	predicted	predict	VERB
biomedich-729	100	3	binding	bind	VERB
biomedich-729	100	4	(	(	PUNCT
biomedich-729	100	5	activatory	activatory	NOUN
biomedich-729	100	6	or	or	CCONJ
biomedich-729	100	7	inhibitory	inhibitory	ADJ
biomedich-729	100	8	)	)	PUNCT
biomedich-729	100	9	effect	effect	NOUN
biomedich-729	100	10	of	of	ADP
biomedich-729	100	11	the	the	DET
biomedich-729	100	12	components	component	NOUN
biomedich-729	100	13	of	of	ADP
biomedich-729	100	14	the	the	DET
biomedich-729	100	15	extract	extract	NOUN
biomedich-729	100	16	fractions	fraction	NOUN
biomedich-729	100	17	to	to	ADP
biomedich-729	100	18	proteins	protein	NOUN
biomedich-729	100	19	identified	identify	VERB
biomedich-729	100	20	by	by	ADP
biomedich-729	100	21	the	the	DET
biomedich-729	100	22	tox21	tox21	PROPN
biomedich-729	100	23	program	program	NOUN
biomedich-729	100	24	as	as	ADP
biomedich-729	100	25	significant	significant	ADJ
biomedich-729	100	26	predictors	predictor	NOUN
biomedich-729	100	27	of	of	ADP
biomedich-729	100	28	toxicity	toxicity	NOUN
biomedich-729	100	29	is	be	AUX
biomedich-729	100	30	shown	show	VERB
biomedich-729	100	31	in	in	ADP
biomedich-729	100	32	table	table	NOUN
biomedich-729	100	33	4	4	NUM
biomedich-729	100	34	.	.	PUNCT
biomedich-729	101	1	a	a	DET
biomedich-729	101	2	total	total	NOUN
biomedich-729	101	3	of	of	ADP
biomedich-729	101	4	11	11	NUM
biomedich-729	101	5	compounds	compound	NOUN
biomedich-729	101	6	in	in	ADP
biomedich-729	101	7	both	both	DET
biomedich-729	101	8	extract	extract	NOUN
biomedich-729	101	9	fractions	fraction	NOUN
biomedich-729	101	10	have	have	VERB
biomedich-729	101	11	from	from	ADP
biomedich-729	101	12	high	high	ADJ
biomedich-729	101	13	to	to	ADP
biomedich-729	101	14	very	very	ADV
biomedich-729	101	15	high	high	ADJ
biomedich-729	101	16	potential	potential	NOUN
biomedich-729	101	17	to	to	PART
biomedich-729	101	18	bind	bind	VERB
biomedich-729	101	19	to	to	ADP
biomedich-729	101	20	the	the	DET
biomedich-729	101	21	nuclear	nuclear	ADJ
biomedich-729	101	22	receptor	receptor	NOUN
biomedich-729	101	23	protein	protein	NOUN
biomedich-729	101	24	,	,	PUNCT
biomedich-729	101	25	peroxisome	peroxisome	VERB
biomedich-729	101	26	proliferator	proliferator	NOUN
biomedich-729	101	27	-	-	PUNCT
biomedich-729	101	28	activated	activate	VERB
biomedich-729	101	29	receptor	receptor	NOUN
biomedich-729	101	30	gamma	gamma	NOUN
biomedich-729	101	31	(	(	PUNCT
biomedich-729	101	32	nr	nr	NOUN
biomedich-729	101	33	-	-	PUNCT
biomedich-729	101	34	ppar	ppar	NOUN
biomedich-729	101	35	-	-	PUNCT
biomedich-729	101	36	gamma	gamma	NOUN
biomedich-729	101	37	)	)	PUNCT
biomedich-729	101	38	.	.	PUNCT
biomedich-729	102	1	out	out	ADP
biomedich-729	102	2	of	of	ADP
biomedich-729	102	3	these	these	DET
biomedich-729	102	4	11	11	NUM
biomedich-729	102	5	compounds	compound	NOUN
biomedich-729	102	6	,	,	PUNCT
biomedich-729	102	7	eight	eight	NUM
biomedich-729	102	8	are	be	AUX
biomedich-729	102	9	in	in	ADP
biomedich-729	102	10	the	the	DET
biomedich-729	102	11	non	non	ADJ
biomedich-729	102	12	-	-	ADJ
biomedich-729	102	13	polar	polar	ADJ
biomedich-729	102	14	fraction	fraction	NOUN
biomedich-729	102	15	,	,	PUNCT
biomedich-729	102	16	they	they	PRON
biomedich-729	102	17	are	be	AUX
biomedich-729	102	18	fatty	fatty	ADJ
biomedich-729	102	19	acids	acid	NOUN
biomedich-729	102	20	and	and	CCONJ
biomedich-729	102	21	fatty	fatty	NOUN
biomedich-729	102	22	acid	acid	NOUN
biomedich-729	102	23	derivatives	derivative	NOUN
biomedich-729	102	24	,	,	PUNCT
biomedich-729	102	25	and	and	CCONJ
biomedich-729	102	26	they	they	PRON
biomedich-729	102	27	make	make	VERB
biomedich-729	102	28	up	up	ADP
biomedich-729	102	29	about	about	ADV
biomedich-729	102	30	43	43	NUM
biomedich-729	102	31	%	%	NOUN
biomedich-729	102	32	proportion	proportion	NOUN
biomedich-729	102	33	by	by	ADP
biomedich-729	102	34	mass	mass	NOUN
biomedich-729	102	35	in	in	ADP
biomedich-729	102	36	the	the	DET
biomedich-729	102	37	extract	extract	NOUN
biomedich-729	102	38	fraction	fraction	NOUN
biomedich-729	102	39	.	.	PUNCT
biomedich-729	103	1	2	2	X
biomedich-729	103	2	-	-	NUM
biomedich-729	103	3	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	103	4	is	be	AUX
biomedich-729	103	5	the	the	DET
biomedich-729	103	6	only	only	ADJ
biomedich-729	103	7	non	non	ADJ
biomedich-729	103	8	-	-	ADJ
biomedich-729	103	9	fatty	fatty	ADJ
biomedich-729	103	10	acid	acid	NOUN
biomedich-729	103	11	component	component	NOUN
biomedich-729	103	12	of	of	ADP
biomedich-729	103	13	the	the	DET
biomedich-729	103	14	polar	polar	ADJ
biomedich-729	103	15	extract	extract	NOUN
biomedich-729	103	16	fraction	fraction	NOUN
biomedich-729	103	17	that	that	PRON
biomedich-729	103	18	could	could	AUX
biomedich-729	103	19	bind	bind	VERB
biomedich-729	103	20	strongly	strongly	ADV
biomedich-729	103	21	to	to	ADP
biomedich-729	103	22	nr	nr	NOUN
biomedich-729	103	23	-	-	PUNCT
biomedich-729	103	24	ppar	ppar	NOUN
biomedich-729	103	25	-	-	PUNCT
biomedich-729	103	26	gamma	gamma	NOUN
biomedich-729	103	27	.	.	PUNCT
biomedich-729	104	1	from	from	ADP
biomedich-729	104	2	the	the	DET
biomedich-729	104	3	two	two	NUM
biomedich-729	104	4	extract	extract	NOUN
biomedich-729	104	5	fractions	fraction	NOUN
biomedich-729	104	6	,	,	PUNCT
biomedich-729	104	7	a	a	DET
biomedich-729	104	8	total	total	NOUN
biomedich-729	104	9	of	of	ADP
biomedich-729	104	10	10	10	NUM
biomedich-729	104	11	compounds	compound	NOUN
biomedich-729	104	12	could	could	AUX
biomedich-729	104	13	strongly	strongly	ADV
biomedich-729	104	14	induce	induce	VERB
biomedich-729	104	15	the	the	DET
biomedich-729	104	16	stress	stress	ADJ
biomedich-729	104	17	response	response	NOUN
biomedich-729	104	18	pathway	pathway	NOUN
biomedich-729	104	19	leading	lead	VERB
biomedich-729	104	20	to	to	ADP
biomedich-729	104	21	the	the	DET
biomedich-729	104	22	disruption	disruption	NOUN
biomedich-729	104	23	of	of	ADP
biomedich-729	104	24	mitochondrial	mitochondrial	ADJ
biomedich-729	104	25	membrane	membrane	NOUN
biomedich-729	104	26	potential	potential	NOUN
biomedich-729	104	27	(	(	PUNCT
biomedich-729	104	28	sr	sr	PROPN
biomedich-729	104	29	-	-	PUNCT
biomedich-729	104	30	mmp	mmp	PROPN
biomedich-729	104	31	)	)	PUNCT
biomedich-729	104	32	.	.	PUNCT
biomedich-729	105	1	2	2	NUM
biomedich-729	105	2	-	-	PUNCT
biomedich-729	105	3	hydroxychalcone	hydroxychalcone	ADJ
biomedich-729	105	4	,	,	PUNCT
biomedich-729	105	5	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	105	6	-	-	PUNCT
biomedich-729	105	7	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	105	8	.	.	PUNCT
biomedich-729	106	1	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	106	2	,	,	PUNCT
biomedich-729	106	3	methanesulfonic	methanesulfonic	ADJ
biomedich-729	106	4	acid	acid	NOUN
biomedich-729	106	5	,	,	PUNCT
biomedich-729	106	6	17	17	NUM
biomedich-729	106	7	-	-	PUNCT
biomedich-729	106	8	cyano-10,13dimethylhexadecahydrocyclopenta[a]phenanthren-17	cyano-10,13dimethylhexadecahydrocyclopenta[a]phenanthren-17	NOUN
biomedich-729	106	9	-	-	PUNCT
biomedich-729	106	10	yl	yl	NOUN
biomedich-729	106	11	ester	ester	NOUN
biomedich-729	106	12	,	,	PUNCT
biomedich-729	106	13	and	and	CCONJ
biomedich-729	106	14	stigmasterol	stigmasterol	NOUN
biomedich-729	106	15	are	be	AUX
biomedich-729	106	16	compounds	compound	NOUN
biomedich-729	106	17	that	that	PRON
biomedich-729	106	18	could	could	AUX
biomedich-729	106	19	disrupt	disrupt	VERB
biomedich-729	106	20	mitochondrial	mitochondrial	ADJ
biomedich-729	106	21	membrane	membrane	NOUN
biomedich-729	106	22	potential	potential	NOUN
biomedich-729	106	23	in	in	ADP
biomedich-729	106	24	the	the	DET
biomedich-729	106	25	polar	polar	ADJ
biomedich-729	106	26	fraction	fraction	NOUN
biomedich-729	106	27	,	,	PUNCT
biomedich-729	106	28	and	and	CCONJ
biomedich-729	106	29	in	in	ADP
biomedich-729	106	30	the	the	DET
biomedich-729	106	31	non	non	ADJ
biomedich-729	106	32	-	-	ADJ
biomedich-729	106	33	polar	polar	ADJ
biomedich-729	106	34	fraction	fraction	NOUN
biomedich-729	106	35	of	of	ADP
biomedich-729	106	36	the	the	DET
biomedich-729	106	37	extract	extract	NOUN
biomedich-729	106	38	,	,	PUNCT
biomedich-729	106	39	the	the	DET
biomedich-729	106	40	same	same	ADJ
biomedich-729	106	41	effect	effect	NOUN
biomedich-729	106	42	could	could	AUX
biomedich-729	106	43	be	be	AUX
biomedich-729	106	44	induced	induce	VERB
biomedich-729	106	45	by	by	ADP
biomedich-729	106	46	1-(4	1-(4	PROPN
biomedich-729	106	47	-	-	PUNCT
biomedich-729	106	48	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	106	49	,	,	PUNCT
biomedich-729	106	50	naphthalene	naphthalene	NOUN
biomedich-729	106	51	,	,	PUNCT
biomedich-729	106	52	decahydro-2	decahydro-2	NOUN
biomedich-729	106	53	-	-	PUNCT
biomedich-729	106	54	methyl-	methyl-	NOUN
biomedich-729	106	55	,	,	PUNCT
biomedich-729	106	56	2	2	NUM
biomedich-729	106	57	-	-	PUNCT
biomedich-729	106	58	dodecen-1	dodecen-1	NUM
biomedich-729	106	59	-	-	ADJ
biomedich-729	106	60	yl(-)succinic	yl(-)succinic	ADJ
biomedich-729	106	61	anhydride	anhydride	NOUN
biomedich-729	106	62	,	,	PUNCT
biomedich-729	106	63	γ	γ	NOUN
biomedich-729	106	64	-	-	PUNCT
biomedich-729	106	65	sitosterol	sitosterol	NOUN
biomedich-729	106	66	,	,	PUNCT
biomedich-729	106	67	stigmasterol	stigmasterol	NOUN
biomedich-729	106	68	,	,	PUNCT
biomedich-729	106	69	and	and	CCONJ
biomedich-729	106	70	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	106	71	-	-	PUNCT
biomedich-729	106	72	diene	diene	NOUN
biomedich-729	106	73	.	.	PUNCT
biomedich-729	107	1	374	374	NUM
biomedich-729	107	2	biology	biology	NOUN
biomedich-729	107	3	,	,	PUNCT
biomedich-729	107	4	medicine	medicine	NOUN
biomedich-729	107	5	,	,	PUNCT
biomedich-729	107	6	&	&	CCONJ
biomedich-729	107	7	natural	natural	ADJ
biomedich-729	107	8	product	product	NOUN
biomedich-729	107	9	chemistry	chemistry	NOUN
biomedich-729	107	10	14	14	NUM
biomedich-729	107	11	(	(	PUNCT
biomedich-729	107	12	1	1	NUM
biomedich-729	107	13	)	)	PUNCT
biomedich-729	107	14	,	,	PUNCT
biomedich-729	107	15	2025	2025	NUM
biomedich-729	107	16	:	:	PUNCT
biomedich-729	107	17	369	369	NUM
biomedich-729	107	18	-	-	SYM
biomedich-729	107	19	379	379	NUM
biomedich-729	107	20	table	table	NOUN
biomedich-729	107	21	4	4	NUM
biomedich-729	107	22	.	.	PUNCT
biomedich-729	107	23	numbers	number	NOUN
biomedich-729	107	24	of	of	ADP
biomedich-729	107	25	cola	cola	NOUN
biomedich-729	107	26	rostrata	rostrata	NOUN
biomedich-729	107	27	extract	extract	VERB
biomedich-729	107	28	components	component	NOUN
biomedich-729	107	29	with	with	ADP
biomedich-729	107	30	inhibitory	inhibitory	ADJ
biomedich-729	107	31	binding	bind	VERB
biomedich-729	107	32	potential	potential	NOUN
biomedich-729	107	33	against	against	ADP
biomedich-729	107	34	tox21	tox21	PROPN
biomedich-729	107	35	proteins	protein	NOUN
biomedich-729	107	36	.	.	PUNCT
biomedich-729	108	1	no	no	DET
biomedich-729	108	2	binding	bind	VERB
biomedich-729	108	3	very	very	ADV
biomedich-729	108	4	low	low	ADJ
biomedich-729	108	5	low	low	ADJ
biomedich-729	108	6	medium	medium	ADJ
biomedich-729	108	7	high	high	ADJ
biomedich-729	108	8	very	very	ADV
biomedich-729	108	9	high	high	ADJ
biomedich-729	108	10	np	np	INTJ
biomedich-729	108	11	p	p	X
biomedich-729	108	12	np	np	INTJ
biomedich-729	108	13	p	p	X
biomedich-729	109	1	np	np	INTJ
biomedich-729	109	2	p	p	X
biomedich-729	109	3	np	np	INTJ
biomedich-729	109	4	p	p	X
biomedich-729	109	5	np	np	INTJ
biomedich-729	109	6	p	p	X
biomedich-729	109	7	np	np	INTJ
biomedich-729	109	8	p	p	PROPN
biomedich-729	109	9	nr	nr	PROPN
biomedich-729	109	10	-	-	PROPN
biomedich-729	109	11	ar	ar	NOUN
biomedich-729	109	12	14	14	NUM
biomedich-729	109	13	17	17	NUM
biomedich-729	109	14	4	4	NUM
biomedich-729	109	15	0	0	NUM
biomedich-729	109	16	8	8	NUM
biomedich-729	109	17	3	3	NUM
biomedich-729	109	18	1	1	NUM
biomedich-729	109	19	0	0	NUM
biomedich-729	109	20	1	1	NUM
biomedich-729	109	21	1	1	NUM
biomedich-729	109	22	0	0	NUM
biomedich-729	109	23	0	0	NUM
biomedich-729	109	24	nr	nr	PROPN
biomedich-729	109	25	-	-	PUNCT
biomedich-729	109	26	ar	ar	NOUN
biomedich-729	109	27	-	-	PROPN
biomedich-729	109	28	lbd	lbd	NOUN
biomedich-729	109	29	28	28	NUM
biomedich-729	109	30	20	20	NUM
biomedich-729	109	31	0	0	NUM
biomedich-729	109	32	0	0	NUM
biomedich-729	109	33	0	0	NUM
biomedich-729	109	34	0	0	NUM
biomedich-729	109	35	0	0	NUM
biomedich-729	109	36	1	1	NUM
biomedich-729	109	37	0	0	NUM
biomedich-729	109	38	0	0	NUM
biomedich-729	109	39	0	0	NUM
biomedich-729	109	40	0	0	NUM
biomedich-729	110	1	nr	nr	PROPN
biomedich-729	110	2	-	-	PUNCT
biomedich-729	110	3	ahr	ahr	PROPN
biomedich-729	110	4	26	26	NUM
biomedich-729	110	5	16	16	NUM
biomedich-729	110	6	0	0	NUM
biomedich-729	110	7	1	1	NUM
biomedich-729	110	8	0	0	NUM
biomedich-729	110	9	1	1	NUM
biomedich-729	110	10	1	1	NUM
biomedich-729	110	11	1	1	NUM
biomedich-729	110	12	0	0	NUM
biomedich-729	110	13	0	0	NUM
biomedich-729	110	14	1	1	NUM
biomedich-729	110	15	2	2	NUM
biomedich-729	110	16	nr	nr	NOUN
biomedich-729	110	17	-	-	PUNCT
biomedich-729	110	18	aromatase	aromatase	NOUN
biomedich-729	110	19	18	18	NUM
biomedich-729	110	20	12	12	NUM
biomedich-729	110	21	6	6	NUM
biomedich-729	110	22	4	4	NUM
biomedich-729	110	23	1	1	NUM
biomedich-729	110	24	2	2	NUM
biomedich-729	110	25	3	3	NUM
biomedich-729	110	26	1	1	NUM
biomedich-729	110	27	0	0	NUM
biomedich-729	110	28	1	1	NUM
biomedich-729	110	29	0	0	NUM
biomedich-729	110	30	1	1	NUM
biomedich-729	110	31	nr	nr	PROPN
biomedich-729	110	32	-	-	PROPN
biomedich-729	110	33	er	er	INTJ
biomedich-729	110	34	3	3	NUM
biomedich-729	110	35	7	7	NUM
biomedich-729	110	36	12	12	NUM
biomedich-729	110	37	8	8	NUM
biomedich-729	110	38	12	12	NUM
biomedich-729	110	39	4	4	NUM
biomedich-729	110	40	0	0	NUM
biomedich-729	110	41	1	1	NUM
biomedich-729	110	42	0	0	NUM
biomedich-729	110	43	0	0	NUM
biomedich-729	110	44	1	1	NUM
biomedich-729	110	45	1	1	NUM
biomedich-729	110	46	nr	nr	PROPN
biomedich-729	110	47	-	-	PUNCT
biomedich-729	110	48	er	er	INTJ
biomedich-729	110	49	-	-	PUNCT
biomedich-729	110	50	lbd	lbd	NOUN
biomedich-729	110	51	19	19	NUM
biomedich-729	110	52	12	12	NUM
biomedich-729	110	53	1	1	NUM
biomedich-729	110	54	3	3	NUM
biomedich-729	110	55	3	3	NUM
biomedich-729	110	56	1	1	NUM
biomedich-729	110	57	1	1	NUM
biomedich-729	110	58	2	2	NUM
biomedich-729	110	59	2	2	NUM
biomedich-729	110	60	2	2	NUM
biomedich-729	110	61	2	2	NUM
biomedich-729	110	62	1	1	NUM
biomedich-729	110	63	nr	nr	NOUN
biomedich-729	110	64	-	-	PUNCT
biomedich-729	110	65	ppar	ppar	NOUN
biomedich-729	110	66	-	-	PUNCT
biomedich-729	110	67	gamma	gamma	NOUN
biomedich-729	110	68	14	14	NUM
biomedich-729	110	69	12	12	NUM
biomedich-729	110	70	4	4	NUM
biomedich-729	110	71	3	3	NUM
biomedich-729	110	72	2	2	NUM
biomedich-729	110	73	2	2	NUM
biomedich-729	110	74	0	0	NUM
biomedich-729	110	75	1	1	NUM
biomedich-729	110	76	0	0	NUM
biomedich-729	110	77	1	1	NUM
biomedich-729	110	78	8	8	NUM
biomedich-729	110	79	2	2	NUM
biomedich-729	110	80	sr	sr	PROPN
biomedich-729	110	81	-	-	PUNCT
biomedich-729	110	82	are	be	AUX
biomedich-729	110	83	11	11	NUM
biomedich-729	110	84	10	10	NUM
biomedich-729	110	85	10	10	NUM
biomedich-729	110	86	4	4	NUM
biomedich-729	110	87	5	5	NUM
biomedich-729	110	88	5	5	NUM
biomedich-729	110	89	1	1	NUM
biomedich-729	110	90	1	1	NUM
biomedich-729	110	91	0	0	NUM
biomedich-729	110	92	0	0	NUM
biomedich-729	110	93	1	1	NUM
biomedich-729	110	94	1	1	NUM
biomedich-729	110	95	sr	sr	PROPN
biomedich-729	110	96	-	-	PUNCT
biomedich-729	110	97	atad5	atad5	PROPN
biomedich-729	110	98	26	26	NUM
biomedich-729	110	99	20	20	NUM
biomedich-729	110	100	1	1	NUM
biomedich-729	110	101	0	0	NUM
biomedich-729	110	102	0	0	NUM
biomedich-729	110	103	0	0	NUM
biomedich-729	110	104	0	0	NUM
biomedich-729	110	105	0	0	NUM
biomedich-729	110	106	0	0	NUM
biomedich-729	110	107	1	1	NUM
biomedich-729	110	108	1	1	NUM
biomedich-729	110	109	0	0	NUM
biomedich-729	110	110	sr	sr	PROPN
biomedich-729	110	111	-	-	PUNCT
biomedich-729	110	112	hse	hse	PROPN
biomedich-729	110	113	8	8	NUM
biomedich-729	110	114	9	9	NUM
biomedich-729	110	115	11	11	NUM
biomedich-729	110	116	4	4	NUM
biomedich-729	110	117	3	3	NUM
biomedich-729	110	118	5	5	NUM
biomedich-729	110	119	3	3	NUM
biomedich-729	110	120	1	1	NUM
biomedich-729	110	121	1	1	NUM
biomedich-729	110	122	1	1	NUM
biomedich-729	110	123	2	2	NUM
biomedich-729	110	124	1	1	NUM
biomedich-729	110	125	sr	sr	PROPN
biomedich-729	110	126	-	-	PUNCT
biomedich-729	110	127	mmp	mmp	PROPN
biomedich-729	110	128	6	6	NUM
biomedich-729	110	129	4	4	NUM
biomedich-729	110	130	11	11	NUM
biomedich-729	110	131	6	6	NUM
biomedich-729	110	132	5	5	NUM
biomedich-729	110	133	3	3	NUM
biomedich-729	110	134	0	0	NUM
biomedich-729	110	135	4	4	NUM
biomedich-729	110	136	4	4	NUM
biomedich-729	110	137	1	1	NUM
biomedich-729	110	138	2	2	NUM
biomedich-729	110	139	3	3	NUM
biomedich-729	110	140	sr	sr	PROPN
biomedich-729	110	141	-	-	PUNCT
biomedich-729	110	142	p53	p53	NOUN
biomedich-729	110	143	25	25	NUM
biomedich-729	110	144	16	16	NUM
biomedich-729	110	145	1	1	NUM
biomedich-729	110	146	1	1	NUM
biomedich-729	110	147	0	0	NUM
biomedich-729	110	148	2	2	NUM
biomedich-729	110	149	0	0	NUM
biomedich-729	110	150	1	1	NUM
biomedich-729	110	151	0	0	NUM
biomedich-729	110	152	0	0	NUM
biomedich-729	110	153	2	2	NUM
biomedich-729	110	154	1	1	NUM
biomedich-729	110	155	estrogen	estrogen	NOUN
biomedich-729	110	156	receptor	receptor	NOUN
biomedich-729	110	157	-	-	PUNCT
biomedich-729	110	158	ligand	ligand	NOUN
biomedich-729	110	159	-	-	PUNCT
biomedich-729	110	160	binding	bind	VERB
biomedich-729	110	161	domain	domain	NOUN
biomedich-729	110	162	(	(	PUNCT
biomedich-729	110	163	nr	nr	NOUN
biomedich-729	110	164	-	-	PUNCT
biomedich-729	110	165	er	er	INTJ
biomedich-729	110	166	-	-	PUNCT
biomedich-729	110	167	lbd	lbd	PROPN
biomedich-729	110	168	peroxisome	peroxisome	PROPN
biomedich-729	110	169	proliferator	proliferator	PROPN
biomedich-729	110	170	-	-	PUNCT
biomedich-729	110	171	activated	activate	VERB
biomedich-729	110	172	receptor	receptor	NOUN
biomedich-729	110	173	gamma	gamma	NOUN
biomedich-729	110	174	(	(	PUNCT
biomedich-729	110	175	nr	nr	NOUN
biomedich-729	110	176	-	-	PUNCT
biomedich-729	110	177	ppar	ppar	NOUN
biomedich-729	110	178	-	-	PUNCT
biomedich-729	110	179	gamma	gamma	NOUN
biomedich-729	110	180	)	)	PUNCT
biomedich-729	110	181	mitochondrial	mitochondrial	ADJ
biomedich-729	110	182	membrane	membrane	NOUN
biomedich-729	110	183	potential	potential	NOUN
biomedich-729	110	184	(	(	PUNCT
biomedich-729	110	185	sr	sr	PROPN
biomedich-729	110	186	-	-	PUNCT
biomedich-729	110	187	mmp	mmp	PROPN
biomedich-729	110	188	)	)	PUNCT
biomedich-729	110	189	tumor	tumor	NOUN
biomedich-729	110	190	suppressor	suppressor	NOUN
biomedich-729	110	191	protein	protein	NOUN
biomedich-729	110	192	(	(	PUNCT
biomedich-729	110	193	sr	sr	PROPN
biomedich-729	110	194	-	-	PUNCT
biomedich-729	110	195	p53	p53	NOUN
biomedich-729	110	196	)	)	PUNCT
biomedich-729	110	197	,	,	PUNCT
biomedich-729	110	198	heat	heat	NOUN
biomedich-729	110	199	shock	shock	NOUN
biomedich-729	110	200	factor	factor	NOUN
biomedich-729	110	201	response	response	NOUN
biomedich-729	110	202	element	element	NOUN
biomedich-729	110	203	(	(	PUNCT
biomedich-729	110	204	sr	sr	PROPN
biomedich-729	110	205	-	-	PUNCT
biomedich-729	110	206	hse	hse	PROPN
biomedich-729	110	207	)	)	PUNCT
biomedich-729	110	208	,	,	PUNCT
biomedich-729	110	209	antioxidant	antioxidant	ADJ
biomedich-729	110	210	response	response	NOUN
biomedich-729	110	211	element	element	NOUN
biomedich-729	110	212	(	(	PUNCT
biomedich-729	110	213	sr	sr	PROPN
biomedich-729	110	214	-	-	PUNCT
biomedich-729	110	215	are	be	AUX
biomedich-729	110	216	)	)	PUNCT
biomedich-729	110	217	,	,	PUNCT
biomedich-729	110	218	estrogen	estrogen	NOUN
biomedich-729	110	219	receptor	receptor	NOUN
biomedich-729	110	220	(	(	PUNCT
biomedich-729	110	221	nr	nr	NOUN
biomedich-729	110	222	-	-	PROPN
biomedich-729	110	223	er	er	ADJ
biomedich-729	110	224	)	)	PUNCT
biomedich-729	110	225	,	,	PUNCT
biomedich-729	110	226	aryl	aryl	NOUN
biomedich-729	110	227	hydrocarbon	hydrocarbon	NOUN
biomedich-729	110	228	receptor	receptor	NOUN
biomedich-729	110	229	(	(	PUNCT
biomedich-729	110	230	nr	nr	NOUN
biomedich-729	110	231	-	-	PUNCT
biomedich-729	110	232	ahr	ahr	NOUN
biomedich-729	110	233	)	)	PUNCT
biomedich-729	110	234	and	and	CCONJ
biomedich-729	110	235	atpase	atpase	PROPN
biomedich-729	110	236	family	family	NOUN
biomedich-729	110	237	aaa	aaa	NOUN
biomedich-729	110	238	domain	domain	NOUN
biomedich-729	110	239	-	-	PUNCT
biomedich-729	110	240	containing	contain	VERB
biomedich-729	110	241	protein	protein	NOUN
biomedich-729	110	242	5	5	NUM
biomedich-729	110	243	(	(	PUNCT
biomedich-729	110	244	sr	sr	PROPN
biomedich-729	110	245	-	-	PUNCT
biomedich-729	110	246	atad5	atad5	PROPN
biomedich-729	110	247	)	)	PUNCT
biomedich-729	110	248	.	.	PUNCT
biomedich-729	111	1	a	a	DET
biomedich-729	111	2	total	total	NOUN
biomedich-729	111	3	of	of	ADP
biomedich-729	111	4	seven	seven	NUM
biomedich-729	111	5	compounds	compound	NOUN
biomedich-729	111	6	(	(	PUNCT
biomedich-729	111	7	mostly	mostly	ADV
biomedich-729	111	8	those	those	PRON
biomedich-729	111	9	with	with	ADP
biomedich-729	111	10	the	the	DET
biomedich-729	111	11	gonane	gonane	ADJ
biomedich-729	111	12	nucleus	nucleus	NOUN
biomedich-729	111	13	)	)	PUNCT
biomedich-729	111	14	have	have	VERB
biomedich-729	111	15	high	high	ADJ
biomedich-729	111	16	to	to	PART
biomedich-729	111	17	very	very	ADV
biomedich-729	111	18	high	high	ADJ
biomedich-729	111	19	probability	probability	NOUN
biomedich-729	111	20	of	of	ADP
biomedich-729	111	21	binding	bind	VERB
biomedich-729	111	22	to	to	ADP
biomedich-729	111	23	estrogen	estrogen	NOUN
biomedich-729	111	24	receptor	receptor	NOUN
biomedich-729	111	25	-	-	PUNCT
biomedich-729	111	26	ligand	ligand	NOUN
biomedich-729	111	27	-	-	PUNCT
biomedich-729	111	28	binding	bind	VERB
biomedich-729	111	29	domain	domain	NOUN
biomedich-729	111	30	(	(	PUNCT
biomedich-729	111	31	nr	nr	NOUN
biomedich-729	111	32	-	-	PUNCT
biomedich-729	111	33	er	er	INTJ
biomedich-729	111	34	-	-	PUNCT
biomedich-729	111	35	lbd	lbd	NOUN
biomedich-729	111	36	)	)	PUNCT
biomedich-729	111	37	and	and	CCONJ
biomedich-729	111	38	activating	activate	VERB
biomedich-729	111	39	series	series	NOUN
biomedich-729	111	40	of	of	ADP
biomedich-729	111	41	reactions	reaction	NOUN
biomedich-729	111	42	that	that	PRON
biomedich-729	111	43	result	result	VERB
biomedich-729	111	44	in	in	ADP
biomedich-729	111	45	endocrine	endocrine	ADJ
biomedich-729	111	46	disruption	disruption	NOUN
biomedich-729	111	47	.	.	PUNCT
biomedich-729	112	1	in	in	ADP
biomedich-729	112	2	the	the	DET
biomedich-729	112	3	non	non	ADJ
biomedich-729	112	4	-	-	ADJ
biomedich-729	112	5	polar	polar	ADJ
biomedich-729	112	6	fraction	fraction	NOUN
biomedich-729	112	7	,	,	PUNCT
biomedich-729	112	8	γ	γ	PROPN
biomedich-729	112	9	-	-	PUNCT
biomedich-729	112	10	sitosterol	sitosterol	NOUN
biomedich-729	112	11	,	,	PUNCT
biomedich-729	112	12	stigmasterol	stigmasterol	NOUN
biomedich-729	112	13	and	and	CCONJ
biomedich-729	112	14	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	112	15	-	-	PUNCT
biomedich-729	112	16	diene	diene	NOUN
biomedich-729	112	17	have	have	VERB
biomedich-729	112	18	strong	strong	ADJ
biomedich-729	112	19	potential	potential	NOUN
biomedich-729	112	20	to	to	PART
biomedich-729	112	21	bind	bind	VERB
biomedich-729	112	22	to	to	ADP
biomedich-729	112	23	the	the	DET
biomedich-729	112	24	ligand	ligand	NOUN
biomedich-729	112	25	-	-	PUNCT
biomedich-729	112	26	binding	bind	VERB
biomedich-729	112	27	domain	domain	NOUN
biomedich-729	112	28	of	of	ADP
biomedich-729	112	29	estrogen	estrogen	NOUN
biomedich-729	112	30	receptor	receptor	NOUN
biomedich-729	112	31	;	;	PUNCT
biomedich-729	112	32	in	in	ADP
biomedich-729	112	33	the	the	DET
biomedich-729	112	34	polar	polar	ADJ
biomedich-729	112	35	fraction	fraction	NOUN
biomedich-729	112	36	of	of	ADP
biomedich-729	112	37	the	the	DET
biomedich-729	112	38	extract	extract	NOUN
biomedich-729	112	39	,	,	PUNCT
biomedich-729	112	40	the	the	DET
biomedich-729	112	41	same	same	ADJ
biomedich-729	112	42	potential	potential	NOUN
biomedich-729	112	43	is	be	AUX
biomedich-729	112	44	seen	see	VERB
biomedich-729	112	45	in	in	ADP
biomedich-729	112	46	2	2	NUM
biomedich-729	112	47	-	-	PUNCT
biomedich-729	112	48	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	112	49	,	,	PUNCT
biomedich-729	112	50	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	112	51	-	-	PUNCT
biomedich-729	112	52	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	112	53	.	.	NUM
biomedich-729	112	54	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	112	55	and	and	CCONJ
biomedich-729	112	56	stigmasterol	stigmasterol	NOUN
biomedich-729	112	57	.	.	PUNCT
biomedich-729	113	1	among	among	ADP
biomedich-729	113	2	all	all	DET
biomedich-729	113	3	the	the	DET
biomedich-729	113	4	compounds	compound	NOUN
biomedich-729	113	5	identified	identify	VERB
biomedich-729	113	6	in	in	ADP
biomedich-729	113	7	the	the	DET
biomedich-729	113	8	two	two	NUM
biomedich-729	113	9	extract	extract	NOUN
biomedich-729	113	10	fractions	fraction	NOUN
biomedich-729	113	11	,	,	PUNCT
biomedich-729	113	12	2	2	NUM
biomedich-729	113	13	-	-	PUNCT
biomedich-729	113	14	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	113	15	is	be	AUX
biomedich-729	113	16	the	the	DET
biomedich-729	113	17	most	most	ADV
biomedich-729	113	18	toxic	toxic	ADJ
biomedich-729	113	19	component	component	NOUN
biomedich-729	113	20	of	of	ADP
biomedich-729	113	21	the	the	DET
biomedich-729	113	22	epicarp	epicarp	ADJ
biomedich-729	113	23	extract	extract	NOUN
biomedich-729	113	24	of	of	ADP
biomedich-729	113	25	c.	c.	PROPN
biomedich-729	113	26	rostrata	rostrata	PROPN
biomedich-729	113	27	since	since	SCONJ
biomedich-729	113	28	it	it	PRON
biomedich-729	113	29	could	could	AUX
biomedich-729	113	30	cause	cause	VERB
biomedich-729	113	31	liver	liver	NOUN
biomedich-729	113	32	damage	damage	NOUN
biomedich-729	113	33	,	,	PUNCT
biomedich-729	113	34	disrupt	disrupt	VERB
biomedich-729	113	35	mitochondrial	mitochondrial	ADJ
biomedich-729	113	36	membrane	membrane	NOUN
biomedich-729	113	37	potential	potential	NOUN
biomedich-729	113	38	,	,	PUNCT
biomedich-729	113	39	modulate	modulate	VERB
biomedich-729	113	40	sugar	sugar	NOUN
biomedich-729	113	41	metabolism	metabolism	NOUN
biomedich-729	113	42	through	through	ADP
biomedich-729	113	43	nr	nr	NOUN
biomedich-729	113	44	-	-	ADJ
biomedich-729	113	45	ppar	ppar	NOUN
biomedich-729	113	46	-	-	PUNCT
biomedich-729	113	47	gamma	gamma	NOUN
biomedich-729	113	48	activation	activation	NOUN
biomedich-729	113	49	,	,	PUNCT
biomedich-729	113	50	and	and	CCONJ
biomedich-729	113	51	disrupt	disrupt	VERB
biomedich-729	113	52	endocrine	endocrine	ADJ
biomedich-729	113	53	function	function	NOUN
biomedich-729	113	54	through	through	ADP
biomedich-729	113	55	its	its	PRON
biomedich-729	113	56	effect	effect	NOUN
biomedich-729	113	57	on	on	ADP
biomedich-729	113	58	the	the	DET
biomedich-729	113	59	estrogen	estrogen	NOUN
biomedich-729	113	60	receptor	receptor	NOUN
biomedich-729	113	61	.	.	PUNCT
biomedich-729	114	1	in	in	ADP
biomedich-729	114	2	addition	addition	NOUN
biomedich-729	114	3	to	to	ADP
biomedich-729	114	4	2	2	NUM
biomedich-729	114	5	-	-	PUNCT
biomedich-729	114	6	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	114	7	’s	’s	PART
biomedich-729	114	8	inhibitory	inhibitory	ADJ
biomedich-729	114	9	effects	effect	NOUN
biomedich-729	114	10	on	on	ADP
biomedich-729	114	11	members	member	NOUN
biomedich-729	114	12	of	of	ADP
biomedich-729	114	13	the	the	DET
biomedich-729	114	14	cytochrome	cytochrome	ADJ
biomedich-729	114	15	p450	p450	PROPN
biomedich-729	114	16	family	family	NOUN
biomedich-729	114	17	,	,	PUNCT
biomedich-729	114	18	it	it	PRON
biomedich-729	114	19	could	could	AUX
biomedich-729	114	20	also	also	ADV
biomedich-729	114	21	bind	bind	VERB
biomedich-729	114	22	strongly	strongly	ADV
biomedich-729	114	23	to	to	ADP
biomedich-729	114	24	and	and	CCONJ
biomedich-729	114	25	modulate	modulate	VERB
biomedich-729	114	26	the	the	DET
biomedich-729	114	27	functions	function	NOUN
biomedich-729	114	28	of	of	ADP
biomedich-729	114	29	tumor	tumor	NOUN
biomedich-729	114	30	suppressor	suppressor	NOUN
biomedich-729	114	31	protein	protein	NOUN
biomedich-729	114	32	(	(	PUNCT
biomedich-729	114	33	sr	sr	PROPN
biomedich-729	114	34	-	-	PUNCT
biomedich-729	114	35	p53	p53	NOUN
biomedich-729	114	36	)	)	PUNCT
biomedich-729	114	37	,	,	PUNCT
biomedich-729	114	38	heat	heat	NOUN
biomedich-729	114	39	shock	shock	NOUN
biomedich-729	114	40	factor	factor	NOUN
biomedich-729	114	41	response	response	NOUN
biomedich-729	114	42	element	element	NOUN
biomedich-729	114	43	(	(	PUNCT
biomedich-729	114	44	sr	sr	PROPN
biomedich-729	114	45	-	-	PUNCT
biomedich-729	114	46	hse	hse	PROPN
biomedich-729	114	47	)	)	PUNCT
biomedich-729	114	48	,	,	PUNCT
biomedich-729	114	49	antioxidant	antioxidant	ADJ
biomedich-729	114	50	response	response	NOUN
biomedich-729	114	51	element	element	NOUN
biomedich-729	114	52	(	(	PUNCT
biomedich-729	114	53	srare	srare	ADJ
biomedich-729	114	54	)	)	PUNCT
biomedich-729	114	55	,	,	PUNCT
biomedich-729	114	56	estrogen	estrogen	NOUN
biomedich-729	114	57	receptor	receptor	NOUN
biomedich-729	114	58	(	(	PUNCT
biomedich-729	114	59	nr	nr	NOUN
biomedich-729	114	60	-	-	PROPN
biomedich-729	114	61	er	er	ADJ
biomedich-729	114	62	)	)	PUNCT
biomedich-729	114	63	,	,	PUNCT
biomedich-729	114	64	aryl	aryl	NOUN
biomedich-729	114	65	hydrocarbon	hydrocarbon	NOUN
biomedich-729	114	66	receptor	receptor	NOUN
biomedich-729	114	67	(	(	PUNCT
biomedich-729	114	68	nr	nr	NOUN
biomedich-729	114	69	-	-	PUNCT
biomedich-729	114	70	ahr	ahr	NOUN
biomedich-729	114	71	)	)	PUNCT
biomedich-729	114	72	and	and	CCONJ
biomedich-729	114	73	atpase	atpase	PROPN
biomedich-729	114	74	family	family	NOUN
biomedich-729	114	75	aaa	aaa	NOUN
biomedich-729	114	76	domaincontaining	domaincontaine	VERB
biomedich-729	114	77	protein	protein	NOUN
biomedich-729	114	78	5	5	NUM
biomedich-729	114	79	(	(	PUNCT
biomedich-729	114	80	sr	sr	PROPN
biomedich-729	114	81	-	-	PUNCT
biomedich-729	114	82	atad5	atad5	PROPN
biomedich-729	114	83	)	)	PUNCT
biomedich-729	114	84	.	.	PUNCT
biomedich-729	115	1	next	next	ADV
biomedich-729	115	2	to	to	ADP
biomedich-729	115	3	2hydroxychalcone	2hydroxychalcone	NUM
biomedich-729	115	4	is	be	AUX
biomedich-729	115	5	1-(4	1-(4	NUM
biomedich-729	115	6	-	-	PUNCT
biomedich-729	115	7	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	115	8	which	which	PRON
biomedich-729	115	9	also	also	ADV
biomedich-729	115	10	has	have	VERB
biomedich-729	115	11	strong	strong	ADJ
biomedich-729	115	12	potential	potential	NOUN
biomedich-729	115	13	to	to	PART
biomedich-729	115	14	induce	induce	VERB
biomedich-729	115	15	liver	liver	NOUN
biomedich-729	115	16	damage	damage	NOUN
biomedich-729	115	17	and	and	CCONJ
biomedich-729	115	18	mutation	mutation	NOUN
biomedich-729	115	19	,	,	PUNCT
biomedich-729	115	20	and	and	CCONJ
biomedich-729	115	21	disrupt	disrupt	VERB
biomedich-729	115	22	mitochondrial	mitochondrial	ADJ
biomedich-729	115	23	membrane	membrane	NOUN
biomedich-729	115	24	potential	potential	NOUN
biomedich-729	115	25	.	.	PUNCT
biomedich-729	116	1	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	116	2	-	-	PUNCT
biomedich-729	116	3	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	116	4	could	could	AUX
biomedich-729	116	5	also	also	ADV
biomedich-729	116	6	predict	predict	VERB
biomedich-729	116	7	to	to	PART
biomedich-729	116	8	bind	bind	VERB
biomedich-729	116	9	strongly	strongly	ADV
biomedich-729	116	10	to	to	ADP
biomedich-729	116	11	and	and	CCONJ
biomedich-729	116	12	modulate	modulate	VERB
biomedich-729	116	13	the	the	DET
biomedich-729	116	14	functions	function	NOUN
biomedich-729	116	15	of	of	ADP
biomedich-729	116	16	sr	sr	PROPN
biomedich-729	116	17	-	-	PUNCT
biomedich-729	116	18	are	be	AUX
biomedich-729	116	19	,	,	PUNCT
biomedich-729	116	20	nr	nr	PROPN
biomedich-729	116	21	-	-	PUNCT
biomedich-729	116	22	ahr	ahr	PROPN
biomedich-729	116	23	,	,	PUNCT
biomedich-729	116	24	nr	nr	PROPN
biomedich-729	116	25	-	-	PROPN
biomedich-729	116	26	er	er	INTJ
biomedich-729	116	27	,	,	PUNCT
biomedich-729	116	28	sr	sr	PROPN
biomedich-729	116	29	-	-	PUNCT
biomedich-729	116	30	atd5	atd5	PROPN
biomedich-729	116	31	,	,	PUNCT
biomedich-729	116	32	and	and	CCONJ
biomedich-729	116	33	members	member	NOUN
biomedich-729	116	34	of	of	ADP
biomedich-729	116	35	the	the	DET
biomedich-729	116	36	cyp450	cyp450	NOUN
biomedich-729	116	37	family	family	NOUN
biomedich-729	116	38	,	,	PUNCT
biomedich-729	116	39	while	while	SCONJ
biomedich-729	116	40	also	also	ADV
biomedich-729	116	41	disrupting	disrupt	VERB
biomedich-729	116	42	mitochondrial	mitochondrial	ADJ
biomedich-729	116	43	membrane	membrane	NOUN
biomedich-729	116	44	potential	potential	NOUN
biomedich-729	116	45	.	.	PUNCT
biomedich-729	117	1	some	some	PRON
biomedich-729	117	2	of	of	ADP
biomedich-729	117	3	the	the	DET
biomedich-729	117	4	compounds	compound	NOUN
biomedich-729	117	5	present	present	ADJ
biomedich-729	117	6	in	in	ADP
biomedich-729	117	7	the	the	DET
biomedich-729	117	8	extract	extract	NOUN
biomedich-729	117	9	that	that	PRON
biomedich-729	117	10	have	have	AUX
biomedich-729	117	11	been	be	AUX
biomedich-729	117	12	predicted	predict	VERB
biomedich-729	117	13	to	to	PART
biomedich-729	117	14	cause	cause	VERB
biomedich-729	117	15	toxic	toxic	ADJ
biomedich-729	117	16	outcomes	outcome	NOUN
biomedich-729	117	17	are	be	AUX
biomedich-729	117	18	presented	present	VERB
biomedich-729	117	19	in	in	ADP
biomedich-729	117	20	figure	figure	NOUN
biomedich-729	117	21	1	1	NUM
biomedich-729	117	22	.	.	PUNCT
biomedich-729	117	23	analysis	analysis	NOUN
biomedich-729	117	24	of	of	ADP
biomedich-729	117	25	binding	bind	VERB
biomedich-729	117	26	energies	energy	NOUN
biomedich-729	117	27	the	the	DET
biomedich-729	117	28	docking	docking	NOUN
biomedich-729	117	29	experiment	experiment	NOUN
biomedich-729	117	30	revealed	reveal	VERB
biomedich-729	117	31	that	that	SCONJ
biomedich-729	117	32	components	component	NOUN
biomedich-729	117	33	of	of	ADP
biomedich-729	117	34	the	the	DET
biomedich-729	117	35	fractions	fraction	NOUN
biomedich-729	117	36	of	of	ADP
biomedich-729	117	37	c.	c.	PROPN
biomedich-729	117	38	rostrata	rostrata	PROPN
biomedich-729	117	39	epicarp	epicarp	ADJ
biomedich-729	117	40	extracts	extract	NOUN
biomedich-729	117	41	,	,	PUNCT
biomedich-729	117	42	2hydroxychalcone	2hydroxychalcone	NUM
biomedich-729	117	43	,	,	PUNCT
biomedich-729	117	44	1-(4	1-(4	NUM
biomedich-729	117	45	-	-	PUNCT
biomedich-729	117	46	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	117	47	,	,	PUNCT
biomedich-729	117	48	and	and	CCONJ
biomedich-729	117	49	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	117	50	-	-	PUNCT
biomedich-729	117	51	trien14.alpha	trien14.alpha	PROPN
biomedich-729	117	52	.	.	PUNCT
biomedich-729	117	53	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	117	54	,	,	PUNCT
biomedich-729	117	55	are	be	AUX
biomedich-729	117	56	potent	potent	ADJ
biomedich-729	117	57	inhibitors	inhibitor	NOUN
biomedich-729	117	58	of	of	ADP
biomedich-729	117	59	cyp2c19	cyp2c19	NOUN
biomedich-729	117	60	and	and	CCONJ
biomedich-729	117	61	cyp1a2	cyp1a2	ADJ
biomedich-729	117	62	;	;	PUNCT
biomedich-729	117	63	the	the	DET
biomedich-729	117	64	three	three	NUM
biomedich-729	117	65	compounds	compound	NOUN
biomedich-729	117	66	showed	show	VERB
biomedich-729	117	67	strong	strong	ADJ
biomedich-729	117	68	binding	bind	VERB
biomedich-729	117	69	affinity	affinity	NOUN
biomedich-729	117	70	for	for	ADP
biomedich-729	117	71	the	the	DET
biomedich-729	117	72	four	four	NUM
biomedich-729	117	73	subunits	subunit	NOUN
biomedich-729	117	74	of	of	ADP
biomedich-729	117	75	cyp2c19	cyp2c19	PROPN
biomedich-729	117	76	,	,	PUNCT
biomedich-729	117	77	having	have	VERB
biomedich-729	117	78	average	average	ADJ
biomedich-729	117	79	free	free	ADJ
biomedich-729	117	80	energy	energy	NOUN
biomedich-729	117	81	of	of	ADP
biomedich-729	117	82	-7.21	-7.21	NOUN
biomedich-729	117	83	,	,	PUNCT
biomedich-729	117	84	-9.65	-9.65	NUM
biomedich-729	117	85	and	and	CCONJ
biomedich-729	117	86	-8.62	-8.62	NOUN
biomedich-729	117	87	kcal	kcal	PROPN
biomedich-729	117	88	/	/	SYM
biomedich-729	117	89	mol	mol	PROPN
biomedich-729	117	90	,	,	PUNCT
biomedich-729	117	91	respectively	respectively	ADV
biomedich-729	117	92	.	.	PUNCT
biomedich-729	118	1	table	table	NOUN
biomedich-729	118	2	4	4	NUM
biomedich-729	118	3	shows	show	VERB
biomedich-729	118	4	the	the	DET
biomedich-729	118	5	binding	bind	VERB
biomedich-729	118	6	energies	energy	NOUN
biomedich-729	118	7	of	of	ADP
biomedich-729	118	8	selected	select	VERB
biomedich-729	118	9	components	component	NOUN
biomedich-729	118	10	of	of	ADP
biomedich-729	118	11	the	the	DET
biomedich-729	118	12	extract	extract	NOUN
biomedich-729	118	13	fractions	fraction	NOUN
biomedich-729	118	14	with	with	ADP
biomedich-729	118	15	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	118	16	,	,	PUNCT
biomedich-729	118	17	nadh	nadh	NOUN
biomedich-729	118	18	dehydrogenase	dehydrogenase	NOUN
biomedich-729	118	19	and	and	CCONJ
biomedich-729	118	20	two	two	NUM
biomedich-729	118	21	members	member	NOUN
biomedich-729	118	22	of	of	ADP
biomedich-729	118	23	the	the	DET
biomedich-729	118	24	cyp450	cyp450	NOUN
biomedich-729	118	25	family	family	NOUN
biomedich-729	118	26	.	.	PUNCT
biomedich-729	119	1	out	out	ADP
biomedich-729	119	2	of	of	ADP
biomedich-729	119	3	the	the	DET
biomedich-729	119	4	three	three	NUM
biomedich-729	119	5	components	component	NOUN
biomedich-729	119	6	of	of	ADP
biomedich-729	119	7	the	the	DET
biomedich-729	119	8	extract	extract	NOUN
biomedich-729	119	9	used	use	VERB
biomedich-729	119	10	in	in	ADP
biomedich-729	119	11	the	the	DET
biomedich-729	119	12	molecular	molecular	ADJ
biomedich-729	119	13	docking	docking	NOUN
biomedich-729	119	14	experiment	experiment	NOUN
biomedich-729	119	15	,	,	PUNCT
biomedich-729	119	16	1-(4	1-(4	NUM
biomedich-729	119	17	-	-	PUNCT
biomedich-729	119	18	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	119	19	showed	show	VERB
biomedich-729	119	20	the	the	DET
biomedich-729	119	21	strongest	strong	ADJ
biomedich-729	119	22	binding	bind	VERB
biomedich-729	119	23	affinity	affinity	NOUN
biomedich-729	119	24	for	for	ADP
biomedich-729	119	25	cyp2c19	cyp2c19	NOUN
biomedich-729	119	26	and	and	CCONJ
biomedich-729	119	27	nadh	nadh	NOUN
biomedich-729	119	28	dehydrogenase	dehydrogenase	NOUN
biomedich-729	119	29	with	with	ADP
biomedich-729	119	30	the	the	DET
biomedich-729	119	31	compound	compound	NOUN
biomedich-729	119	32	binding	bind	VERB
biomedich-729	119	33	strongly	strongly	ADV
biomedich-729	119	34	to	to	ADP
biomedich-729	119	35	each	each	PRON
biomedich-729	119	36	of	of	ADP
biomedich-729	119	37	the	the	DET
biomedich-729	119	38	four	four	NUM
biomedich-729	119	39	subunits	subunit	NOUN
biomedich-729	119	40	of	of	ADP
biomedich-729	119	41	cyp2c19	cyp2c19	PROPN
biomedich-729	119	42	.	.	PROPN
biomedich-729	120	1	2	2	NUM
biomedich-729	120	2	-	-	PUNCT
biomedich-729	120	3	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	120	4	has	have	VERB
biomedich-729	120	5	the	the	DET
biomedich-729	120	6	strongest	strong	ADJ
biomedich-729	120	7	affinity	affinity	NOUN
biomedich-729	120	8	for	for	ADP
biomedich-729	120	9	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	120	10	,	,	PUNCT
biomedich-729	120	11	binding	bind	VERB
biomedich-729	120	12	to	to	ADP
biomedich-729	120	13	the	the	DET
biomedich-729	120	14	b	b	NOUN
biomedich-729	120	15	subunit	subunit	NOUN
biomedich-729	120	16	with	with	ADP
biomedich-729	120	17	a	a	DET
biomedich-729	120	18	free	free	ADJ
biomedich-729	120	19	energy	energy	NOUN
biomedich-729	120	20	of	of	ADP
biomedich-729	120	21	–	–	PUNCT
biomedich-729	120	22	7.49	7.49	NUM
biomedich-729	120	23	kcal	kcal	NOUN
biomedich-729	120	24	/	/	SYM
biomedich-729	120	25	mol	mol	PROPN
biomedich-729	120	26	.	.	PROPN
biomedich-729	120	27	ajayi	ajayi	PROPN
biomedich-729	120	28	et	et	PROPN
biomedich-729	120	29	al	al	PROPN
biomedich-729	120	30	.	.	PROPN
biomedich-729	120	31	–	–	PUNCT
biomedich-729	120	32	toxicity	toxicity	NOUN
biomedich-729	120	33	prediction	prediction	NOUN
biomedich-729	120	34	of	of	ADP
biomedich-729	120	35	cola	cola	PROPN
biomedich-729	120	36	rostrata	rostrata	PROPN
biomedich-729	120	37	epicarp	epicarp	ADJ
biomedich-729	120	38	375	375	NUM
biomedich-729	120	39	figure	figure	NOUN
biomedich-729	120	40	1	1	NUM
biomedich-729	120	41	.	.	PUNCT
biomedich-729	121	1	some	some	DET
biomedich-729	121	2	components	component	NOUN
biomedich-729	121	3	of	of	ADP
biomedich-729	121	4	ethanol	ethanol	NOUN
biomedich-729	121	5	extract	extract	NOUN
biomedich-729	121	6	of	of	ADP
biomedich-729	121	7	c.	c.	PROPN
biomedich-729	121	8	rostrata	rostrata	PROPN
biomedich-729	121	9	epicarp	epicarp	PROPN
biomedich-729	121	10	predicted	predict	VERB
biomedich-729	121	11	to	to	PART
biomedich-729	121	12	have	have	VERB
biomedich-729	121	13	toxic	toxic	ADJ
biomedich-729	121	14	effects	effect	NOUN
biomedich-729	121	15	.	.	PUNCT
biomedich-729	122	1	(	(	PUNCT
biomedich-729	122	2	a	a	X
biomedich-729	122	3	)	)	PUNCT
biomedich-729	122	4	2	2	NUM
biomedich-729	122	5	-	-	PUNCT
biomedich-729	122	6	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	122	7	,	,	PUNCT
biomedich-729	122	8	(	(	PUNCT
biomedich-729	122	9	b	b	NOUN
biomedich-729	122	10	)	)	PUNCT
biomedich-729	122	11	1-(4	1-(4	NUM
biomedich-729	122	12	-	-	PUNCT
biomedich-729	122	13	methoxyphenylazo)2	methoxyphenylazo)2	NOUN
biomedich-729	122	14	-	-	PUNCT
biomedich-729	122	15	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	122	16	,	,	PUNCT
biomedich-729	122	17	(	(	PUNCT
biomedich-729	122	18	c	c	NOUN
biomedich-729	122	19	)	)	PUNCT
biomedich-729	122	20	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	122	21	-	-	PUNCT
biomedich-729	122	22	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	122	23	.	.	PUNCT
biomedich-729	122	24	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	122	25	,	,	PUNCT
biomedich-729	122	26	(	(	PUNCT
biomedich-729	122	27	d	d	NOUN
biomedich-729	122	28	)	)	PUNCT
biomedich-729	122	29	4	4	NUM
biomedich-729	122	30	-	-	PUNCT
biomedich-729	122	31	methoxy-6	methoxy-6	NUM
biomedich-729	122	32	-	-	PUNCT
biomedich-729	122	33	methyl-5	methyl-5	NOUN
biomedich-729	122	34	-	-	PUNCT
biomedich-729	122	35	nitroisobenzofuran-1,3	nitroisobenzofuran-1,3	NOUN
biomedich-729	122	36	-	-	PUNCT
biomedich-729	122	37	dione	dione	NOUN
biomedich-729	122	38	,	,	PUNCT
biomedich-729	122	39	(	(	PUNCT
biomedich-729	122	40	e	e	NOUN
biomedich-729	122	41	)	)	PUNCT
biomedich-729	122	42	z-8	z-8	NUM
biomedich-729	122	43	-	-	PUNCT
biomedich-729	122	44	methyl-9tetradecen-1	methyl-9tetradecen-1	PRON
biomedich-729	122	45	-	-	ADJ
biomedich-729	122	46	ol	ol	ADJ
biomedich-729	122	47	formate	formate	NOUN
biomedich-729	122	48	,	,	PUNCT
biomedich-729	122	49	(	(	PUNCT
biomedich-729	122	50	f	f	X
biomedich-729	122	51	)	)	PUNCT
biomedich-729	122	52	corynan-16	corynan-16	NOUN
biomedich-729	122	53	-	-	PUNCT
biomedich-729	122	54	carboxylic	carboxylic	NOUN
biomedich-729	122	55	acid	acid	NOUN
biomedich-729	122	56	,	,	PUNCT
biomedich-729	122	57	16,17	16,17	ADJ
biomedich-729	122	58	-	-	PUNCT
biomedich-729	122	59	didehydro-9,17	didehydro-9,17	ADJ
biomedich-729	122	60	-	-	PUNCT
biomedich-729	122	61	dimethoxy-	dimethoxy-	NOUN
biomedich-729	122	62	,	,	PUNCT
biomedich-729	122	63	methyl	methyl	NOUN
biomedich-729	122	64	ester	ester	NOUN
biomedich-729	122	65	,	,	PUNCT
biomedich-729	122	66	(	(	PUNCT
biomedich-729	122	67	16e)-	16e)-	NUM
biomedich-729	122	68	,	,	PUNCT
biomedich-729	122	69	(	(	PUNCT
biomedich-729	122	70	g	g	NOUN
biomedich-729	122	71	)	)	PUNCT
biomedich-729	122	72	β	β	NOUN
biomedich-729	122	73	-	-	NOUN
biomedich-729	122	74	sitosterol	sitosterol	NOUN
biomedich-729	122	75	,	,	PUNCT
biomedich-729	122	76	(	(	PUNCT
biomedich-729	122	77	h	h	NOUN
biomedich-729	122	78	)	)	PUNCT
biomedich-729	122	79	methanesulfonic	methanesulfonic	NOUN
biomedich-729	122	80	acid	acid	NOUN
biomedich-729	122	81	,	,	PUNCT
biomedich-729	122	82	17	17	NUM
biomedich-729	122	83	-	-	PUNCT
biomedich-729	122	84	cyano-10,13	cyano-10,13	NOUN
biomedich-729	122	85	-	-	PUNCT
biomedich-729	122	86	dimethylhexadecahydrocyclopenta[a]phenanthren-17	dimethylhexadecahydrocyclopenta[a]phenanthren-17	NOUN
biomedich-729	122	87	-	-	PUNCT
biomedich-729	122	88	yl	yl	NOUN
biomedich-729	122	89	ester	ester	NOUN
biomedich-729	122	90	,	,	PUNCT
biomedich-729	122	91	and	and	CCONJ
biomedich-729	122	92	(	(	PUNCT
biomedich-729	122	93	i	i	NOUN
biomedich-729	122	94	)	)	PUNCT
biomedich-729	123	1	[	[	X
biomedich-729	123	2	1,2,4]triazolo[1,5	1,2,4]triazolo[1,5	NUM
biomedich-729	123	3	-	-	PUNCT
biomedich-729	123	4	a]pyrimidine-6	a]pyrimidine-6	NOUN
biomedich-729	123	5	-	-	PUNCT
biomedich-729	123	6	carboxylic	carboxylic	ADJ
biomedich-729	123	7	acid	acid	NOUN
biomedich-729	123	8	,	,	PUNCT
biomedich-729	123	9	4,7dihydro-7	4,7dihydro-7	NUM
biomedich-729	123	10	-	-	PUNCT
biomedich-729	123	11	imino-	imino-	X
biomedich-729	123	12	,	,	PUNCT
biomedich-729	123	13	ethyl	ethyl	PROPN
biomedich-729	123	14	ester	ester	NOUN
biomedich-729	123	15	.	.	PUNCT
biomedich-729	124	1	examination	examination	NOUN
biomedich-729	124	2	of	of	ADP
biomedich-729	124	3	the	the	DET
biomedich-729	124	4	binding	bind	VERB
biomedich-729	124	5	interactions	interaction	NOUN
biomedich-729	124	6	showed	show	VERB
biomedich-729	124	7	that	that	SCONJ
biomedich-729	124	8	the	the	DET
biomedich-729	124	9	most	most	ADV
biomedich-729	124	10	predominant	predominant	ADJ
biomedich-729	124	11	interaction	interaction	NOUN
biomedich-729	124	12	of	of	ADP
biomedich-729	124	13	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	124	14	-	-	PUNCT
biomedich-729	124	15	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	124	16	with	with	ADP
biomedich-729	124	17	the	the	DET
biomedich-729	124	18	polypeptide	polypeptide	ADJ
biomedich-729	124	19	chain	chain	NOUN
biomedich-729	124	20	d	d	PROPN
biomedich-729	124	21	of	of	ADP
biomedich-729	124	22	cyp2c19	cyp2c19	NOUN
biomedich-729	124	23	are	be	AUX
biomedich-729	124	24	pi	pi	ADJ
biomedich-729	124	25	-	-	PUNCT
biomedich-729	124	26	alkyl	alkyl	ADJ
biomedich-729	124	27	bonds	bond	NOUN
biomedich-729	124	28	with	with	ADP
biomedich-729	124	29	the	the	DET
biomedich-729	124	30	interaction	interaction	NOUN
biomedich-729	124	31	with	with	ADP
biomedich-729	124	32	conventional	conventional	ADJ
biomedich-729	124	33	hydrogen	hydrogen	NOUN
biomedich-729	124	34	bond	bond	NOUN
biomedich-729	124	35	having	have	VERB
biomedich-729	124	36	the	the	DET
biomedich-729	124	37	shortest	short	ADJ
biomedich-729	124	38	bond	bond	NOUN
biomedich-729	124	39	length	length	NOUN
biomedich-729	124	40	of	of	ADP
biomedich-729	124	41	2.93	2.93	NUM
biomedich-729	124	42	å	å	NOUN
biomedich-729	124	43	(	(	PUNCT
biomedich-729	124	44	figure	figure	NOUN
biomedich-729	124	45	2	2	NUM
biomedich-729	124	46	c	c	NOUN
biomedich-729	124	47	)	)	PUNCT
biomedich-729	124	48	.	.	PUNCT
biomedich-729	125	1	other	other	ADJ
biomedich-729	125	2	interactions	interaction	NOUN
biomedich-729	125	3	with	with	ADP
biomedich-729	125	4	the	the	DET
biomedich-729	125	5	polypeptide	polypeptide	ADJ
biomedich-729	125	6	chain	chain	NOUN
biomedich-729	125	7	include	include	VERB
biomedich-729	125	8	van	van	PROPN
biomedich-729	125	9	der	der	ADJ
biomedich-729	125	10	waals	waal	NOUN
biomedich-729	125	11	forces	force	NOUN
biomedich-729	125	12	,	,	PUNCT
biomedich-729	125	13	and	and	CCONJ
biomedich-729	125	14	alkyl	alkyl	ADJ
biomedich-729	125	15	,	,	PUNCT
biomedich-729	125	16	pi	pi	NOUN
biomedich-729	125	17	-	-	PUNCT
biomedich-729	125	18	pi	pi	NOUN
biomedich-729	125	19	t	t	PROPN
biomedich-729	125	20	-	-	PUNCT
biomedich-729	125	21	shaped	shape	VERB
biomedich-729	125	22	,	,	PUNCT
biomedich-729	125	23	pi	pi	NOUN
biomedich-729	125	24	-	-	PUNCT
biomedich-729	125	25	sulfur	sulfur	NOUN
biomedich-729	125	26	,	,	PUNCT
biomedich-729	125	27	pisigma	pisigma	NOUN
biomedich-729	125	28	,	,	PUNCT
biomedich-729	125	29	and	and	CCONJ
biomedich-729	125	30	carbon	carbon	NOUN
biomedich-729	125	31	-	-	PUNCT
biomedich-729	125	32	hydrogen	hydrogen	NOUN
biomedich-729	125	33	bonds	bond	NOUN
biomedich-729	125	34	.	.	PUNCT
biomedich-729	126	1	the	the	DET
biomedich-729	126	2	binding	bind	VERB
biomedich-729	126	3	interaction	interaction	NOUN
biomedich-729	126	4	of	of	ADP
biomedich-729	126	5	1-(4	1-(4	NOUN
biomedich-729	126	6	-	-	PUNCT
biomedich-729	126	7	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	126	8	with	with	ADP
biomedich-729	126	9	cyp2c19	cyp2c19	NOUN
biomedich-729	126	10	shows	show	VERB
biomedich-729	126	11	that	that	SCONJ
biomedich-729	126	12	the	the	DET
biomedich-729	126	13	compound	compound	NOUN
biomedich-729	126	14	binds	bind	VERB
biomedich-729	126	15	to	to	ADP
biomedich-729	126	16	residues	residue	NOUN
biomedich-729	126	17	:	:	PUNCT
biomedich-729	126	18	thr301	thr301	NOUN
biomedich-729	126	19	,	,	PUNCT
biomedich-729	126	20	leu361	leu361	NOUN
biomedich-729	126	21	and	and	CCONJ
biomedich-729	126	22	leu366	leu366	VERB
biomedich-729	126	23	at	at	ADP
biomedich-729	126	24	the	the	DET
biomedich-729	126	25	active	active	ADJ
biomedich-729	126	26	site	site	NOUN
biomedich-729	126	27	of	of	ADP
biomedich-729	126	28	cyp2c19	cyp2c19	PROPN
biomedich-729	126	29	,	,	PUNCT
biomedich-729	126	30	with	with	ADP
biomedich-729	126	31	the	the	DET
biomedich-729	126	32	free	free	ADJ
biomedich-729	126	33	energy	energy	NOUN
biomedich-729	126	34	of	of	ADP
biomedich-729	126	35	-9.93	-9.93	NUM
biomedich-729	126	36	kcal	kcal	PROPN
biomedich-729	126	37	/	/	SYM
biomedich-729	126	38	mol	mol	PROPN
biomedich-729	126	39	.	.	PUNCT
biomedich-729	127	1	also	also	ADV
biomedich-729	127	2	,	,	PUNCT
biomedich-729	127	3	the	the	DET
biomedich-729	127	4	binding	bind	VERB
biomedich-729	127	5	interactions	interaction	NOUN
biomedich-729	127	6	of	of	ADP
biomedich-729	127	7	1-(4	1-(4	NUM
biomedich-729	127	8	-	-	PUNCT
biomedich-729	127	9	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	127	10	-	-	PUNCT
biomedich-729	127	11	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	127	12	to	to	PART
biomedich-729	127	13	nadh	nadh	VERB
biomedich-729	127	14	dehydrogenase	dehydrogenase	NOUN
biomedich-729	127	15	1	1	NUM
biomedich-729	127	16	has	have	VERB
biomedich-729	127	17	pi	pi	NOUN
biomedich-729	127	18	-	-	PUNCT
biomedich-729	127	19	alkyl	alkyl	ADJ
biomedich-729	127	20	bonds	bond	NOUN
biomedich-729	127	21	as	as	ADP
biomedich-729	127	22	the	the	DET
biomedich-729	127	23	predominant	predominant	ADJ
biomedich-729	127	24	interactions	interaction	NOUN
biomedich-729	127	25	,	,	PUNCT
biomedich-729	127	26	nine	nine	NUM
biomedich-729	127	27	bonds	bond	NOUN
biomedich-729	127	28	with	with	ADP
biomedich-729	127	29	residues	residue	NOUN
biomedich-729	127	30	on	on	ADP
biomedich-729	127	31	three	three	NUM
biomedich-729	127	32	subunits	subunit	NOUN
biomedich-729	127	33	(	(	PUNCT
biomedich-729	127	34	r	r	NOUN
biomedich-729	127	35	,	,	PUNCT
biomedich-729	127	36	i	i	PRON
biomedich-729	127	37	and	and	CCONJ
biomedich-729	127	38	v	v	NUM
biomedich-729	127	39	chains	chain	NOUN
biomedich-729	127	40	)	)	PUNCT
biomedich-729	127	41	in	in	ADP
biomedich-729	127	42	cluster	cluster	NOUN
biomedich-729	127	43	3	3	NUM
biomedich-729	127	44	of	of	ADP
biomedich-729	127	45	the	the	DET
biomedich-729	127	46	nadh	nadh	NOUN
biomedich-729	127	47	dehydrogenase	dehydrogenase	NOUN
biomedich-729	127	48	1	1	NUM
biomedich-729	127	49	structure	structure	NOUN
biomedich-729	127	50	(	(	PUNCT
biomedich-729	127	51	figure	figure	NOUN
biomedich-729	127	52	2	2	NUM
biomedich-729	127	53	a	a	NOUN
biomedich-729	127	54	)	)	PUNCT
biomedich-729	127	55	.	.	PUNCT
biomedich-729	128	1	the	the	DET
biomedich-729	128	2	shortest	short	ADJ
biomedich-729	128	3	bond	bond	NOUN
biomedich-729	128	4	distance	distance	NOUN
biomedich-729	128	5	(	(	PUNCT
biomedich-729	128	6	1.88	1.88	NUM
biomedich-729	128	7	å	å	NOUN
biomedich-729	128	8	)	)	PUNCT
biomedich-729	128	9	and	and	CCONJ
biomedich-729	128	10	the	the	DET
biomedich-729	128	11	strongest	strong	ADJ
biomedich-729	128	12	bond	bond	NOUN
biomedich-729	128	13	seen	see	VERB
biomedich-729	128	14	in	in	ADP
biomedich-729	128	15	the	the	DET
biomedich-729	128	16	interactions	interaction	NOUN
biomedich-729	128	17	is	be	AUX
biomedich-729	128	18	the	the	DET
biomedich-729	128	19	conventional	conventional	ADJ
biomedich-729	128	20	hydrogen	hydrogen	NOUN
biomedich-729	128	21	bonding	bonding	NOUN
biomedich-729	128	22	between	between	ADP
biomedich-729	128	23	lone	lone	ADJ
biomedich-729	128	24	pairs	pair	NOUN
biomedich-729	128	25	of	of	ADP
biomedich-729	128	26	electrons	electron	NOUN
biomedich-729	128	27	on	on	ADP
biomedich-729	128	28	the	the	DET
biomedich-729	128	29	hydroxyl	hydroxyl	NOUN
biomedich-729	128	30	group	group	NOUN
biomedich-729	128	31	of	of	ADP
biomedich-729	128	32	1-(4	1-(4	PROPN
biomedich-729	128	33	-	-	PUNCT
biomedich-729	128	34	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	128	35	and	and	CCONJ
biomedich-729	128	36	glu	glu	NOUN
biomedich-729	128	37	v:134	v:134	NOUN
biomedich-729	128	38	.	.	PUNCT
biomedich-729	129	1	other	other	ADJ
biomedich-729	129	2	bonds	bond	NOUN
biomedich-729	129	3	in	in	ADP
biomedich-729	129	4	the	the	DET
biomedich-729	129	5	binding	bind	VERB
biomedich-729	129	6	interaction	interaction	NOUN
biomedich-729	129	7	include	include	VERB
biomedich-729	129	8	pi	pi	ADJ
biomedich-729	129	9	-	-	PUNCT
biomedich-729	129	10	pi	pi	NOUN
biomedich-729	129	11	stacked	stack	VERB
biomedich-729	129	12	,	,	PUNCT
biomedich-729	129	13	pi	pi	NOUN
biomedich-729	129	14	-	-	PUNCT
biomedich-729	129	15	pi	pi	NOUN
biomedich-729	129	16	t	t	PROPN
biomedich-729	129	17	-	-	PUNCT
biomedich-729	129	18	stacked	stack	VERB
biomedich-729	129	19	and	and	CCONJ
biomedich-729	129	20	pi	pi	NOUN
biomedich-729	129	21	-	-	PUNCT
biomedich-729	129	22	donor	donor	NOUN
biomedich-729	129	23	hydrogen	hydrogen	NOUN
biomedich-729	129	24	bonds	bond	NOUN
biomedich-729	129	25	.	.	PUNCT
biomedich-729	130	1	this	this	DET
biomedich-729	130	2	binding	bind	VERB
biomedich-729	130	3	of	of	ADP
biomedich-729	130	4	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	130	5	-	-	PUNCT
biomedich-729	130	6	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	130	7	to	to	PART
biomedich-729	130	8	cluster	cluster	VERB
biomedich-729	130	9	3	3	NUM
biomedich-729	130	10	chains	chain	NOUN
biomedich-729	130	11	has	have	VERB
biomedich-729	130	12	the	the	DET
biomedich-729	130	13	lowest	low	ADJ
biomedich-729	130	14	free	free	ADJ
biomedich-729	130	15	energy	energy	NOUN
biomedich-729	130	16	(	(	PUNCT
biomedich-729	130	17	-7.78	-7.78	NOUN
biomedich-729	130	18	kcal	kcal	PROPN
biomedich-729	130	19	/	/	SYM
biomedich-729	130	20	mol	mol	NOUN
biomedich-729	130	21	)	)	PUNCT
biomedich-729	130	22	of	of	ADP
biomedich-729	130	23	the	the	DET
biomedich-729	130	24	three	three	NUM
biomedich-729	130	25	compounds	compound	NOUN
biomedich-729	130	26	docked	dock	VERB
biomedich-729	130	27	with	with	ADP
biomedich-729	130	28	the	the	DET
biomedich-729	130	29	three	three	NUM
biomedich-729	130	30	chain	chain	NOUN
biomedich-729	130	31	clusters	cluster	NOUN
biomedich-729	130	32	of	of	ADP
biomedich-729	130	33	nadh	nadh	NOUN
biomedich-729	130	34	dehydrogenase	dehydrogenase	NOUN
biomedich-729	130	35	1	1	NUM
biomedich-729	130	36	protein	protein	NOUN
biomedich-729	130	37	.	.	PUNCT
biomedich-729	131	1	the	the	DET
biomedich-729	131	2	interaction	interaction	NOUN
biomedich-729	131	3	of	of	ADP
biomedich-729	131	4	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	131	5	-	-	PUNCT
biomedich-729	131	6	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	131	7	with	with	ADP
biomedich-729	131	8	nadh	nadh	NOUN
biomedich-729	131	9	dehydrogenase	dehydrogenase	NOUN
biomedich-729	131	10	(	(	PUNCT
biomedich-729	131	11	a	a	DET
biomedich-729	131	12	critical	critical	ADJ
biomedich-729	131	13	enzyme	enzyme	NOUN
biomedich-729	131	14	in	in	ADP
biomedich-729	131	15	the	the	DET
biomedich-729	131	16	mitochondrial	mitochondrial	ADJ
biomedich-729	131	17	electron	electron	NOUN
biomedich-729	131	18	transport	transport	NOUN
biomedich-729	131	19	chain	chain	NOUN
biomedich-729	131	20	that	that	PRON
biomedich-729	131	21	plays	play	VERB
biomedich-729	131	22	a	a	DET
biomedich-729	131	23	central	central	ADJ
biomedich-729	131	24	role	role	NOUN
biomedich-729	131	25	in	in	ADP
biomedich-729	131	26	cellular	cellular	ADJ
biomedich-729	131	27	energy	energy	NOUN
biomedich-729	131	28	production	production	NOUN
biomedich-729	131	29	through	through	ADP
biomedich-729	131	30	oxidative	oxidative	ADJ
biomedich-729	131	31	phosphorylation	phosphorylation	NOUN
biomedich-729	131	32	)	)	PUNCT
biomedich-729	131	33	suggests	suggest	VERB
biomedich-729	131	34	the	the	DET
biomedich-729	131	35	potential	potential	ADJ
biomedich-729	131	36	modulation	modulation	NOUN
biomedich-729	131	37	of	of	ADP
biomedich-729	131	38	atp	atp	PROPN
biomedich-729	131	39	production	production	NOUN
biomedich-729	131	40	.	.	PUNCT
biomedich-729	132	1	table	table	NOUN
biomedich-729	132	2	5	5	NUM
biomedich-729	132	3	.	.	PUNCT
biomedich-729	133	1	binding	bind	VERB
biomedich-729	133	2	free	free	ADJ
biomedich-729	133	3	energy	energy	NOUN
biomedich-729	133	4	(	(	PUNCT
biomedich-729	133	5	kcal	kcal	NOUN
biomedich-729	133	6	/	/	SYM
biomedich-729	133	7	mol	mol	NOUN
biomedich-729	133	8	)	)	PUNCT
biomedich-729	133	9	of	of	ADP
biomedich-729	133	10	three	three	NUM
biomedich-729	133	11	components	component	NOUN
biomedich-729	133	12	of	of	ADP
biomedich-729	133	13	cola	cola	PROPN
biomedich-729	133	14	rostrata	rostrata	PROPN
biomedich-729	133	15	extract	extract	VERB
biomedich-729	133	16	to	to	ADP
biomedich-729	133	17	selected	select	VERB
biomedich-729	133	18	cellular	cellular	ADJ
biomedich-729	133	19	proteins	protein	NOUN
biomedich-729	133	20	.	.	PUNCT
biomedich-729	134	1	components	component	NOUN
biomedich-729	134	2	of	of	ADP
biomedich-729	134	3	cola	cola	PROPN
biomedich-729	134	4	rostrata	rostrata	PROPN
biomedich-729	134	5	epicarp	epicarp	ADJ
biomedich-729	134	6	extract	extract	VERB
biomedich-729	134	7	na+k+-atpase	na+k+-atpase	PROPN
biomedich-729	134	8	nadh	nadh	NOUN
biomedich-729	134	9	dehydrogenase	dehydrogenase	NOUN
biomedich-729	134	10	1	1	NUM
biomedich-729	134	11	cyp2c19	cyp2c19	NOUN
biomedich-729	134	12	cyp1a2	cyp1a2	PROPN
biomedich-729	134	13	a	a	DET
biomedich-729	134	14	b	b	PROPN
biomedich-729	134	15	c	c	PROPN
biomedich-729	134	16	cluster	cluster	NOUN
biomedich-729	134	17	1	1	NUM
biomedich-729	134	18	cluster	cluster	NOUN
biomedich-729	134	19	2	2	NUM
biomedich-729	134	20	cluster	cluster	NOUN
biomedich-729	134	21	3	3	NUM
biomedich-729	134	22	a	a	DET
biomedich-729	134	23	b	b	NOUN
biomedich-729	134	24	c	c	NOUN
biomedich-729	134	25	d	d	SYM
biomedich-729	134	26	2	2	NUM
biomedich-729	134	27	-	-	PUNCT
biomedich-729	134	28	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	134	29	-5.41	-5.41	NOUN
biomedich-729	134	30	-7.49	-7.49	NOUN
biomedich-729	134	31	-4.97	-4.97	VERB
biomedich-729	134	32	-5.48	-5.48	NUM
biomedich-729	134	33	-6.82	-6.82	NUM
biomedich-729	134	34	-5.77	-5.77	ADJ
biomedich-729	134	35	-8.07	-8.07	INTJ
biomedich-729	134	36	-7.11	-7.11	NUM
biomedich-729	134	37	-6.89	-6.89	NUM
biomedich-729	134	38	-6.77	-6.77	PRON
biomedich-729	134	39	-7.31	-7.31	NUM
biomedich-729	134	40	1-(4	1-(4	NUM
biomedich-729	134	41	-	-	PUNCT
biomedich-729	134	42	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	134	43	-5.76	-5.76	NOUN
biomedich-729	135	1	-5.58	-5.58	NUM
biomedich-729	135	2	-5.13	-5.13	NUM
biomedich-729	135	3	-6.86	-6.86	INTJ
biomedich-729	135	4	-6.46	-6.46	INTJ
biomedich-729	135	5	-7.78	-7.78	NOUN
biomedich-729	135	6	-9.68	-9.68	PROPN
biomedich-729	135	7	-9.52	-9.52	INTJ
biomedich-729	135	8	-9.49	-9.49	NUM
biomedich-729	135	9	-9.93	-9.93	NUM
biomedich-729	135	10	-7.51	-7.51	NOUN
biomedich-729	135	11	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	135	12	-	-	PUNCT
biomedich-729	135	13	trien14.alpha	trien14.alpha	PROPN
biomedich-729	135	14	.	.	PUNCT
biomedich-729	135	15	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	136	1	-6.00	-6.00	PROPN
biomedich-729	136	2	-5.17	-5.17	NUM
biomedich-729	136	3	-5.25	-5.25	PROPN
biomedich-729	136	4	-6.54	-6.54	PROPN
biomedich-729	136	5	-7.09	-7.09	NUM
biomedich-729	136	6	-7.17	-7.17	PROPN
biomedich-729	136	7	-9.56	-9.56	NOUN
biomedich-729	136	8	-8.16	-8.16	NOUN
biomedich-729	136	9	-7.91	-7.91	PUNCT
biomedich-729	136	10	-8.83	-8.83	ADV
biomedich-729	136	11	-8.71	-8.71	NUM
biomedich-729	136	12	cluster	cluster	NOUN
biomedich-729	136	13	1	1	NUM
biomedich-729	136	14	contains	contain	VERB
biomedich-729	136	15	polypeptide	polypeptide	ADJ
biomedich-729	136	16	chains	chain	NOUN
biomedich-729	136	17	:	:	PUNCT
biomedich-729	136	18	a	a	PRON
biomedich-729	136	19	,	,	PUNCT
biomedich-729	136	20	f	f	X
biomedich-729	136	21	,	,	PUNCT
biomedich-729	136	22	k	k	PROPN
biomedich-729	136	23	,	,	PUNCT
biomedich-729	136	24	l	l	PROPN
biomedich-729	136	25	,	,	PUNCT
biomedich-729	136	26	m	m	PROPN
biomedich-729	136	27	,	,	PUNCT
biomedich-729	136	28	n	n	CCONJ
biomedich-729	136	29	,	,	PUNCT
biomedich-729	136	30	o	o	PROPN
biomedich-729	136	31	and	and	CCONJ
biomedich-729	136	32	t	t	PROPN
biomedich-729	136	33	;	;	PUNCT
biomedich-729	136	34	cluster	cluster	NOUN
biomedich-729	136	35	2	2	NUM
biomedich-729	136	36	contains	contain	VERB
biomedich-729	136	37	polypeptide	polypeptide	ADJ
biomedich-729	136	38	chains	chain	NOUN
biomedich-729	136	39	:	:	PUNCT
biomedich-729	136	40	b	b	X
biomedich-729	136	41	,	,	PUNCT
biomedich-729	136	42	c	c	X
biomedich-729	136	43	,	,	PUNCT
biomedich-729	136	44	e	e	NOUN
biomedich-729	136	45	,	,	PUNCT
biomedich-729	136	46	g	g	PROPN
biomedich-729	136	47	,	,	PUNCT
biomedich-729	136	48	h	h	NOUN
biomedich-729	136	49	,	,	PUNCT
biomedich-729	136	50	i	i	PRON
biomedich-729	136	51	,	,	PUNCT
biomedich-729	136	52	j	j	PROPN
biomedich-729	136	53	,	,	PUNCT
biomedich-729	136	54	j	j	PROPN
biomedich-729	136	55	,	,	PUNCT
biomedich-729	136	56	m	m	PROPN
biomedich-729	136	57	,	,	PUNCT
biomedich-729	136	58	p	p	X
biomedich-729	136	59	,	,	PUNCT
biomedich-729	136	60	q	q	ADJ
biomedich-729	136	61	,	,	PUNCT
biomedich-729	136	62	s	s	PROPN
biomedich-729	136	63	,	,	PUNCT
biomedich-729	136	64	s	s	X
biomedich-729	136	65	,	,	PUNCT
biomedich-729	136	66	u	u	NOUN
biomedich-729	136	67	,	,	PUNCT
biomedich-729	136	68	w	w	PROPN
biomedich-729	136	69	and	and	CCONJ
biomedich-729	136	70	w	w	PROPN
biomedich-729	136	71	;	;	PUNCT
biomedich-729	136	72	cluster	cluster	NOUN
biomedich-729	136	73	3	3	NUM
biomedich-729	136	74	contains	contain	VERB
biomedich-729	136	75	polypeptide	polypeptide	ADJ
biomedich-729	136	76	chains	chain	NOUN
biomedich-729	136	77	:	:	PUNCT
biomedich-729	136	78	a	a	DET
biomedich-729	136	79	,	,	PUNCT
biomedich-729	136	80	b	b	NOUN
biomedich-729	136	81	,	,	PUNCT
biomedich-729	136	82	c	c	NOUN
biomedich-729	136	83	,	,	PUNCT
biomedich-729	136	84	d	d	NOUN
biomedich-729	136	85	,	,	PUNCT
biomedich-729	136	86	e	e	NOUN
biomedich-729	136	87	,	,	PUNCT
biomedich-729	136	88	f	f	PROPN
biomedich-729	136	89	,	,	PUNCT
biomedich-729	136	90	g	g	PROPN
biomedich-729	136	91	,	,	PUNCT
biomedich-729	136	92	h	h	NOUN
biomedich-729	136	93	,	,	PUNCT
biomedich-729	136	94	i	i	PRON
biomedich-729	136	95	,	,	PUNCT
biomedich-729	136	96	k	k	PROPN
biomedich-729	136	97	,	,	PUNCT
biomedich-729	136	98	l	l	NOUN
biomedich-729	136	99	,	,	PUNCT
biomedich-729	136	100	n	n	CCONJ
biomedich-729	136	101	,	,	PUNCT
biomedich-729	136	102	o	o	NOUN
biomedich-729	136	103	,	,	PUNCT
biomedich-729	136	104	p	p	X
biomedich-729	136	105	,	,	PUNCT
biomedich-729	136	106	r	r	NOUN
biomedich-729	136	107	,	,	PUNCT
biomedich-729	136	108	v	v	NOUN
biomedich-729	136	109	,	,	PUNCT
biomedich-729	136	110	v	v	NOUN
biomedich-729	136	111	,	,	PUNCT
biomedich-729	136	112	x	x	NOUN
biomedich-729	136	113	,	,	PUNCT
biomedich-729	136	114	y	y	PROPN
biomedich-729	136	115	and	and	CCONJ
biomedich-729	136	116	z.	z.	PROPN
biomedich-729	136	117	a	a	PRON
biomedich-729	136	118	,	,	PUNCT
biomedich-729	136	119	b	b	NOUN
biomedich-729	136	120	,	,	PUNCT
biomedich-729	136	121	c	c	PROPN
biomedich-729	136	122	and	and	CCONJ
biomedich-729	136	123	d	d	NOUN
biomedich-729	136	124	:	:	PUNCT
biomedich-729	136	125	subunits	subunit	NOUN
biomedich-729	136	126	of	of	ADP
biomedich-729	136	127	the	the	DET
biomedich-729	136	128	indicated	indicate	VERB
biomedich-729	136	129	proteins	protein	NOUN
biomedich-729	136	130	.	.	PUNCT
biomedich-729	137	1	376	376	NUM
biomedich-729	137	2	biology	biology	NOUN
biomedich-729	137	3	,	,	PUNCT
biomedich-729	137	4	medicine	medicine	NOUN
biomedich-729	137	5	,	,	PUNCT
biomedich-729	137	6	&	&	CCONJ
biomedich-729	137	7	natural	natural	ADJ
biomedich-729	137	8	product	product	NOUN
biomedich-729	137	9	chemistry	chemistry	NOUN
biomedich-729	137	10	14	14	NUM
biomedich-729	137	11	(	(	PUNCT
biomedich-729	137	12	1	1	NUM
biomedich-729	137	13	)	)	PUNCT
biomedich-729	137	14	,	,	PUNCT
biomedich-729	137	15	2025	2025	NUM
biomedich-729	137	16	:	:	PUNCT
biomedich-729	137	17	369	369	NUM
biomedich-729	137	18	-	-	SYM
biomedich-729	137	19	379	379	NUM
biomedich-729	137	20	for	for	ADP
biomedich-729	137	21	the	the	DET
biomedich-729	137	22	binding	bind	VERB
biomedich-729	137	23	interactions	interaction	NOUN
biomedich-729	137	24	of	of	ADP
biomedich-729	137	25	2	2	NUM
biomedich-729	137	26	-	-	PUNCT
biomedich-729	137	27	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	137	28	,	,	PUNCT
biomedich-729	137	29	its	its	PRON
biomedich-729	137	30	binding	binding	NOUN
biomedich-729	137	31	to	to	ADP
biomedich-729	137	32	chain	chain	VERB
biomedich-729	137	33	b	b	PROPN
biomedich-729	137	34	of	of	ADP
biomedich-729	137	35	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	137	36	has	have	VERB
biomedich-729	137	37	the	the	DET
biomedich-729	137	38	lowest	low	ADJ
biomedich-729	137	39	free	free	ADJ
biomedich-729	137	40	energy	energy	NOUN
biomedich-729	137	41	(	(	PUNCT
biomedich-729	137	42	-7.74	-7.74	ADJ
biomedich-729	137	43	kcal	kcal	PROPN
biomedich-729	137	44	/	/	SYM
biomedich-729	137	45	mol	mol	NOUN
biomedich-729	137	46	)	)	PUNCT
biomedich-729	137	47	of	of	ADP
biomedich-729	137	48	the	the	DET
biomedich-729	137	49	dockings	docking	NOUN
biomedich-729	137	50	of	of	ADP
biomedich-729	137	51	the	the	DET
biomedich-729	137	52	three	three	NUM
biomedich-729	137	53	compounds	compound	NOUN
biomedich-729	137	54	to	to	ADP
biomedich-729	137	55	the	the	DET
biomedich-729	137	56	chains	chain	NOUN
biomedich-729	137	57	of	of	ADP
biomedich-729	137	58	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	137	59	(	(	PUNCT
biomedich-729	137	60	table	table	NOUN
biomedich-729	137	61	5	5	NUM
biomedich-729	137	62	)	)	PUNCT
biomedich-729	137	63	.	.	PUNCT
biomedich-729	138	1	the	the	DET
biomedich-729	138	2	binding	bind	VERB
biomedich-729	138	3	interaction	interaction	NOUN
biomedich-729	138	4	of	of	ADP
biomedich-729	138	5	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	138	6	to	to	PART
biomedich-729	138	7	chain	chain	VERB
biomedich-729	138	8	b	b	PROPN
biomedich-729	138	9	involves	involve	VERB
biomedich-729	138	10	two	two	NUM
biomedich-729	138	11	conventional	conventional	ADJ
biomedich-729	138	12	hydrogen	hydrogen	NOUN
biomedich-729	138	13	bonds	bond	NOUN
biomedich-729	138	14	linking	link	VERB
biomedich-729	138	15	met	meet	VERB
biomedich-729	138	16	b:202	b:202	PROPN
biomedich-729	138	17	with	with	ADP
biomedich-729	138	18	bond	bond	NOUN
biomedich-729	138	19	distances	distance	NOUN
biomedich-729	138	20	of	of	ADP
biomedich-729	138	21	1.90	1.90	NUM
biomedich-729	138	22	å	å	NOUN
biomedich-729	138	23	and	and	CCONJ
biomedich-729	138	24	2.25	2.25	NUM
biomedich-729	138	25	å	å	NOUN
biomedich-729	138	26	,	,	PUNCT
biomedich-729	138	27	and	and	CCONJ
biomedich-729	138	28	pi	pi	PROPN
biomedich-729	138	29	bonds	bond	NOUN
biomedich-729	138	30	:	:	PUNCT
biomedich-729	138	31	pi	pi	NOUN
biomedich-729	138	32	-	-	PUNCT
biomedich-729	138	33	alkyl	alkyl	ADJ
biomedich-729	138	34	,	,	PUNCT
biomedich-729	138	35	pi	pi	NOUN
biomedich-729	138	36	-	-	PUNCT
biomedich-729	138	37	anion	anion	NOUN
biomedich-729	138	38	,	,	PUNCT
biomedich-729	138	39	pi	pi	NOUN
biomedich-729	138	40	-	-	PUNCT
biomedich-729	138	41	sulfur	sulfur	NOUN
biomedich-729	138	42	and	and	CCONJ
biomedich-729	138	43	pi	pi	NOUN
biomedich-729	138	44	-	-	PUNCT
biomedich-729	138	45	pi	pi	NOUN
biomedich-729	138	46	t	t	PROPN
biomedich-729	138	47	-	-	PUNCT
biomedich-729	138	48	shaped	shaped	ADJ
biomedich-729	138	49	;	;	PUNCT
biomedich-729	138	50	the	the	DET
biomedich-729	138	51	pi	pi	NOUN
biomedich-729	138	52	-	-	PUNCT
biomedich-729	138	53	sulfur	sulfur	NOUN
biomedich-729	138	54	bond	bond	NOUN
biomedich-729	138	55	is	be	AUX
biomedich-729	138	56	also	also	ADV
biomedich-729	138	57	linking	link	VERB
biomedich-729	138	58	met	meet	VERB
biomedich-729	138	59	b:202	b:202	NOUN
biomedich-729	138	60	(	(	PUNCT
biomedich-729	138	61	figure	figure	NOUN
biomedich-729	138	62	2	2	NUM
biomedich-729	138	63	d	d	NOUN
biomedich-729	138	64	)	)	PUNCT
biomedich-729	138	65	.	.	PUNCT
biomedich-729	139	1	the	the	DET
biomedich-729	139	2	binding	binding	NOUN
biomedich-729	139	3	of	of	ADP
biomedich-729	139	4	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	139	5	-	-	PUNCT
biomedich-729	139	6	trien14.alpha	trien14.alpha	PROPN
biomedich-729	139	7	.	.	PUNCT
biomedich-729	139	8	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	139	9	to	to	PART
biomedich-729	139	10	cyp1a2	cyp1a2	PROPN
biomedich-729	139	11	produced	produce	VERB
biomedich-729	139	12	the	the	DET
biomedich-729	139	13	best	well	ADV
biomedich-729	139	14	free	free	ADJ
biomedich-729	139	15	energy	energy	NOUN
biomedich-729	139	16	value	value	NOUN
biomedich-729	139	17	(	(	PUNCT
biomedich-729	139	18	-8.71	-8.71	X
biomedich-729	139	19	kcal	kcal	PROPN
biomedich-729	139	20	/	/	SYM
biomedich-729	139	21	mol	mol	NOUN
biomedich-729	139	22	)	)	PUNCT
biomedich-729	139	23	of	of	ADP
biomedich-729	139	24	the	the	DET
biomedich-729	139	25	three	three	NUM
biomedich-729	139	26	compounds	compound	NOUN
biomedich-729	139	27	docked	dock	VERB
biomedich-729	139	28	with	with	ADP
biomedich-729	139	29	the	the	DET
biomedich-729	139	30	protein	protein	NOUN
biomedich-729	139	31	(	(	PUNCT
biomedich-729	139	32	table	table	NOUN
biomedich-729	139	33	5	5	NUM
biomedich-729	139	34	)	)	PUNCT
biomedich-729	139	35	.	.	PUNCT
biomedich-729	140	1	the	the	DET
biomedich-729	140	2	binding	binding	NOUN
biomedich-729	140	3	of	of	ADP
biomedich-729	140	4	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	140	5	-	-	PUNCT
biomedich-729	140	6	trien14.alpha	trien14.alpha	PROPN
biomedich-729	140	7	.	.	PUNCT
biomedich-729	140	8	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	140	9	to	to	PART
biomedich-729	140	10	cyp1a2	cyp1a2	NOUN
biomedich-729	140	11	involves	involve	VERB
biomedich-729	140	12	alkyl	alkyl	ADJ
biomedich-729	140	13	bonding	bonding	NOUN
biomedich-729	140	14	(	(	PUNCT
biomedich-729	140	15	9	9	NUM
biomedich-729	140	16	bonds	bond	NOUN
biomedich-729	140	17	)	)	PUNCT
biomedich-729	140	18	with	with	ADP
biomedich-729	140	19	hydrophobic	hydrophobic	NOUN
biomedich-729	140	20	aliphatic	aliphatic	ADJ
biomedich-729	140	21	side	side	NOUN
biomedich-729	140	22	chains	chain	NOUN
biomedich-729	140	23	of	of	ADP
biomedich-729	140	24	leu	leu	PROPN
biomedich-729	140	25	and	and	CCONJ
biomedich-729	140	26	ile	ile	PROPN
biomedich-729	140	27	residues	residue	NOUN
biomedich-729	140	28	;	;	PUNCT
biomedich-729	140	29	with	with	ADP
biomedich-729	140	30	the	the	DET
biomedich-729	140	31	bond	bond	NOUN
biomedich-729	140	32	with	with	ADP
biomedich-729	140	33	the	the	DET
biomedich-729	140	34	shortest	short	ADJ
biomedich-729	140	35	distance	distance	NOUN
biomedich-729	140	36	(	(	PUNCT
biomedich-729	140	37	3.46	3.46	NUM
biomedich-729	140	38	å	å	NOUN
biomedich-729	140	39	)	)	PUNCT
biomedich-729	140	40	being	be	AUX
biomedich-729	140	41	the	the	DET
biomedich-729	140	42	alkyl	alkyl	ADJ
biomedich-729	140	43	bond	bond	NOUN
biomedich-729	140	44	formed	form	VERB
biomedich-729	140	45	with	with	ADP
biomedich-729	140	46	cys	cys	PROPN
biomedich-729	140	47	458	458	PROPN
biomedich-729	140	48	(	(	PUNCT
biomedich-729	140	49	figure	figure	NOUN
biomedich-729	140	50	2	2	NUM
biomedich-729	140	51	b	b	NOUN
biomedich-729	140	52	)	)	PUNCT
biomedich-729	140	53	.	.	PUNCT
biomedich-729	141	1	other	other	ADJ
biomedich-729	141	2	bond	bond	NOUN
biomedich-729	141	3	interactions	interaction	NOUN
biomedich-729	141	4	in	in	ADP
biomedich-729	141	5	the	the	DET
biomedich-729	141	6	binding	binding	NOUN
biomedich-729	141	7	of	of	ADP
biomedich-729	141	8	anthiaergostan-5,7,9	anthiaergostan-5,7,9	PROPN
biomedich-729	141	9	-	-	PUNCT
biomedich-729	141	10	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	141	11	.	.	PUNCT
biomedich-729	141	12	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	141	13	to	to	ADP
biomedich-729	141	14	cyp1a	cyp1a	PROPN
biomedich-729	141	15	include	include	VERB
biomedich-729	141	16	,	,	PUNCT
biomedich-729	141	17	pi	pi	NOUN
biomedich-729	141	18	-	-	PUNCT
biomedich-729	141	19	sigma	sigma	NOUN
biomedich-729	141	20	,	,	PUNCT
biomedich-729	141	21	amide	amide	NOUN
biomedich-729	141	22	-	-	PUNCT
biomedich-729	141	23	pi	pi	NOUN
biomedich-729	141	24	stacked	stack	VERB
biomedich-729	141	25	and	and	CCONJ
biomedich-729	141	26	pidonor	pidonor	NOUN
biomedich-729	141	27	hydrogen	hydrogen	NOUN
biomedich-729	141	28	bonds	bond	NOUN
biomedich-729	141	29	.	.	PUNCT
biomedich-729	142	1	figure	figure	NOUN
biomedich-729	142	2	2	2	NUM
biomedich-729	142	3	.	.	PUNCT
biomedich-729	142	4	2d	2d	NOUN
biomedich-729	142	5	images	image	NOUN
biomedich-729	142	6	of	of	ADP
biomedich-729	142	7	the	the	DET
biomedich-729	142	8	molecular	molecular	ADJ
biomedich-729	142	9	binding	bind	VERB
biomedich-729	142	10	interactions	interaction	NOUN
biomedich-729	142	11	of	of	ADP
biomedich-729	142	12	selected	select	VERB
biomedich-729	142	13	components	component	NOUN
biomedich-729	142	14	of	of	ADP
biomedich-729	142	15	cola	cola	PROPN
biomedich-729	142	16	rostrata	rostrata	PROPN
biomedich-729	142	17	extract	extract	VERB
biomedich-729	142	18	with	with	ADP
biomedich-729	142	19	selected	select	VERB
biomedich-729	142	20	cellular	cellular	ADJ
biomedich-729	142	21	proteins	protein	NOUN
biomedich-729	142	22	.	.	PUNCT
biomedich-729	143	1	(	(	PUNCT
biomedich-729	143	2	a	a	X
biomedich-729	143	3	)	)	PUNCT
biomedich-729	143	4	binding	bind	VERB
biomedich-729	143	5	interactions	interaction	NOUN
biomedich-729	143	6	of	of	ADP
biomedich-729	143	7	1-(4	1-(4	NUM
biomedich-729	143	8	-	-	PUNCT
biomedich-729	143	9	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	143	10	-	-	PUNCT
biomedich-729	143	11	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	143	12	with	with	ADP
biomedich-729	143	13	amino	amino	NOUN
biomedich-729	143	14	acid	acid	NOUN
biomedich-729	143	15	residues	residue	NOUN
biomedich-729	143	16	in	in	ADP
biomedich-729	143	17	20	20	NUM
biomedich-729	143	18	subunits	subunit	NOUN
biomedich-729	143	19	(	(	PUNCT
biomedich-729	143	20	a	a	PRON
biomedich-729	143	21	,	,	PUNCT
biomedich-729	143	22	b	b	NOUN
biomedich-729	143	23	,	,	PUNCT
biomedich-729	143	24	c	c	NOUN
biomedich-729	143	25	,	,	PUNCT
biomedich-729	143	26	d	d	NOUN
biomedich-729	143	27	,	,	PUNCT
biomedich-729	143	28	e	e	NOUN
biomedich-729	143	29	,	,	PUNCT
biomedich-729	143	30	f	f	PROPN
biomedich-729	143	31	,	,	PUNCT
biomedich-729	143	32	g	g	PROPN
biomedich-729	143	33	,	,	PUNCT
biomedich-729	143	34	h	h	NOUN
biomedich-729	143	35	,	,	PUNCT
biomedich-729	143	36	i	i	PRON
biomedich-729	143	37	,	,	PUNCT
biomedich-729	143	38	k	k	PROPN
biomedich-729	143	39	,	,	PUNCT
biomedich-729	143	40	l	l	NOUN
biomedich-729	143	41	,	,	PUNCT
biomedich-729	143	42	n	n	CCONJ
biomedich-729	143	43	,	,	PUNCT
biomedich-729	143	44	o	o	NOUN
biomedich-729	143	45	,	,	PUNCT
biomedich-729	143	46	p	p	X
biomedich-729	143	47	,	,	PUNCT
biomedich-729	143	48	r	r	NOUN
biomedich-729	143	49	,	,	PUNCT
biomedich-729	143	50	v	v	NOUN
biomedich-729	143	51	,	,	PUNCT
biomedich-729	143	52	v	v	NOUN
biomedich-729	143	53	,	,	PUNCT
biomedich-729	143	54	x	x	NOUN
biomedich-729	143	55	,	,	PUNCT
biomedich-729	143	56	y	y	PROPN
biomedich-729	143	57	and	and	CCONJ
biomedich-729	143	58	z	z	PROPN
biomedich-729	143	59	)	)	PUNCT
biomedich-729	143	60	of	of	ADP
biomedich-729	143	61	nadh	nadh	NOUN
biomedich-729	143	62	dehydrogenase	dehydrogenase	NOUN
biomedich-729	143	63	1	1	NUM
biomedich-729	143	64	(	(	PUNCT
biomedich-729	143	65	b	b	NOUN
biomedich-729	143	66	)	)	PUNCT
biomedich-729	143	67	binding	bind	VERB
biomedich-729	143	68	interactions	interaction	NOUN
biomedich-729	143	69	of	of	ADP
biomedich-729	143	70	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	143	71	-	-	PUNCT
biomedich-729	143	72	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	143	73	.	.	PUNCT
biomedich-729	143	74	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	143	75	to	to	ADP
biomedich-729	143	76	cyp1a	cyp1a	PROPN
biomedich-729	143	77	(	(	PUNCT
biomedich-729	143	78	c	c	NOUN
biomedich-729	143	79	)	)	PUNCT
biomedich-729	143	80	binding	bind	VERB
biomedich-729	143	81	interactions	interaction	NOUN
biomedich-729	143	82	of	of	ADP
biomedich-729	143	83	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	143	84	-	-	PUNCT
biomedich-729	143	85	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	143	86	to	to	PART
biomedich-729	143	87	chain	chain	VERB
biomedich-729	143	88	d	d	PROPN
biomedich-729	143	89	of	of	ADP
biomedich-729	143	90	cyp2c19	cyp2c19	NOUN
biomedich-729	143	91	(	(	PUNCT
biomedich-729	143	92	d	d	NOUN
biomedich-729	143	93	)	)	PUNCT
biomedich-729	143	94	binding	bind	VERB
biomedich-729	143	95	interactions	interaction	NOUN
biomedich-729	143	96	of	of	ADP
biomedich-729	143	97	2	2	NUM
biomedich-729	143	98	-	-	PUNCT
biomedich-729	143	99	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	143	100	to	to	PART
biomedich-729	143	101	chain	chain	VERB
biomedich-729	143	102	b	b	PROPN
biomedich-729	143	103	of	of	ADP
biomedich-729	143	104	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	143	105	.	.	PUNCT
biomedich-729	144	1	ajayi	ajayi	NOUN
biomedich-729	144	2	et	et	PROPN
biomedich-729	144	3	al	al	PROPN
biomedich-729	144	4	.	.	PROPN
biomedich-729	144	5	–	–	PUNCT
biomedich-729	144	6	toxicity	toxicity	NOUN
biomedich-729	144	7	prediction	prediction	NOUN
biomedich-729	144	8	of	of	ADP
biomedich-729	144	9	cola	cola	PROPN
biomedich-729	144	10	rostrata	rostrata	PROPN
biomedich-729	144	11	epicarp	epicarp	ADJ
biomedich-729	144	12	377	377	NUM
biomedich-729	144	13	discussion	discussion	NOUN
biomedich-729	144	14	the	the	DET
biomedich-729	144	15	ethanol	ethanol	NOUN
biomedich-729	144	16	extract	extract	NOUN
biomedich-729	144	17	of	of	ADP
biomedich-729	144	18	the	the	DET
biomedich-729	144	19	fruit	fruit	NOUN
biomedich-729	144	20	epicarp	epicarp	ADJ
biomedich-729	144	21	of	of	ADP
biomedich-729	144	22	cola	cola	PROPN
biomedich-729	144	23	rostrata	rostrata	PROPN
biomedich-729	144	24	has	have	AUX
biomedich-729	144	25	been	be	AUX
biomedich-729	144	26	found	find	VERB
biomedich-729	144	27	to	to	PART
biomedich-729	144	28	possess	possess	VERB
biomedich-729	144	29	strong	strong	ADJ
biomedich-729	144	30	anticancer	anticancer	NOUN
biomedich-729	144	31	activity	activity	NOUN
biomedich-729	144	32	with	with	ADP
biomedich-729	144	33	potential	potential	NOUN
biomedich-729	144	34	for	for	ADP
biomedich-729	144	35	usage	usage	NOUN
biomedich-729	144	36	against	against	ADP
biomedich-729	144	37	inflammation	inflammation	NOUN
biomedich-729	144	38	,	,	PUNCT
biomedich-729	144	39	pain	pain	NOUN
biomedich-729	144	40	and	and	CCONJ
biomedich-729	144	41	diabetes	diabete	NOUN
biomedich-729	144	42	;	;	PUNCT
biomedich-729	144	43	the	the	DET
biomedich-729	144	44	toxicity	toxicity	NOUN
biomedich-729	144	45	potential	potential	NOUN
biomedich-729	144	46	of	of	ADP
biomedich-729	144	47	this	this	DET
biomedich-729	144	48	extract	extract	NOUN
biomedich-729	144	49	has	have	AUX
biomedich-729	144	50	not	not	PART
biomedich-729	144	51	been	be	AUX
biomedich-729	144	52	evaluated	evaluate	VERB
biomedich-729	144	53	.	.	PUNCT
biomedich-729	145	1	adverse	adverse	ADJ
biomedich-729	145	2	side	side	NOUN
biomedich-729	145	3	effects	effect	NOUN
biomedich-729	145	4	have	have	AUX
biomedich-729	145	5	been	be	AUX
biomedich-729	145	6	identified	identify	VERB
biomedich-729	145	7	as	as	ADP
biomedich-729	145	8	one	one	NUM
biomedich-729	145	9	of	of	ADP
biomedich-729	145	10	the	the	DET
biomedich-729	145	11	barriers	barrier	NOUN
biomedich-729	145	12	to	to	ADP
biomedich-729	145	13	increased	increase	VERB
biomedich-729	145	14	usage	usage	NOUN
biomedich-729	145	15	of	of	ADP
biomedich-729	145	16	herbal	herbal	ADJ
biomedich-729	145	17	preparations	preparation	NOUN
biomedich-729	145	18	(	(	PUNCT
biomedich-729	145	19	awodele	awodele	X
biomedich-729	145	20	et	et	PROPN
biomedich-729	145	21	al	al	PROPN
biomedich-729	145	22	.	.	PROPN
biomedich-729	145	23	,	,	PUNCT
biomedich-729	145	24	2018	2018	NUM
biomedich-729	145	25	;	;	PUNCT
biomedich-729	145	26	vaezi	vaezi	VERB
biomedich-729	145	27	et	et	PROPN
biomedich-729	145	28	al	al	PROPN
biomedich-729	145	29	.	.	PROPN
biomedich-729	145	30	,	,	PUNCT
biomedich-729	145	31	2021	2021	NUM
biomedich-729	145	32	)	)	PUNCT
biomedich-729	145	33	.	.	PUNCT
biomedich-729	146	1	though	though	SCONJ
biomedich-729	146	2	adverse	adverse	ADJ
biomedich-729	146	3	reactions	reaction	NOUN
biomedich-729	146	4	are	be	AUX
biomedich-729	146	5	associated	associate	VERB
biomedich-729	146	6	with	with	ADP
biomedich-729	146	7	several	several	ADJ
biomedich-729	146	8	herbal	herbal	ADJ
biomedich-729	146	9	preparations	preparation	NOUN
biomedich-729	146	10	,	,	PUNCT
biomedich-729	146	11	conventional	conventional	ADJ
biomedich-729	146	12	orthodox	orthodox	ADJ
biomedich-729	146	13	drugs	drug	NOUN
biomedich-729	146	14	like	like	ADP
biomedich-729	146	15	carbamazepine	carbamazepine	NOUN
biomedich-729	146	16	,	,	PUNCT
biomedich-729	146	17	diclofenac	diclofenac	NOUN
biomedich-729	146	18	and	and	CCONJ
biomedich-729	146	19	most	most	ADJ
biomedich-729	146	20	antibiotics	antibiotic	NOUN
biomedich-729	146	21	,	,	PUNCT
biomedich-729	146	22	including	include	VERB
biomedich-729	146	23	tetracycline	tetracycline	NOUN
biomedich-729	146	24	,	,	PUNCT
biomedich-729	146	25	azithromycin	azithromycin	NOUN
biomedich-729	146	26	andmoxifloxacin	andmoxifloxacin	NOUN
biomedich-729	146	27	,	,	PUNCT
biomedich-729	146	28	have	have	AUX
biomedich-729	146	29	been	be	AUX
biomedich-729	146	30	identified	identify	VERB
biomedich-729	146	31	as	as	ADP
biomedich-729	146	32	major	major	ADJ
biomedich-729	146	33	causes	cause	NOUN
biomedich-729	146	34	of	of	ADP
biomedich-729	146	35	liver	liver	NOUN
biomedich-729	146	36	damage	damage	NOUN
biomedich-729	146	37	and	and	CCONJ
biomedich-729	146	38	adverse	adverse	ADJ
biomedich-729	146	39	side	side	NOUN
biomedich-729	146	40	effects	effect	NOUN
biomedich-729	146	41	(	(	PUNCT
biomedich-729	146	42	chalasani	chalasani	X
biomedich-729	146	43	et	et	PROPN
biomedich-729	146	44	al	al	PROPN
biomedich-729	146	45	.	.	PROPN
biomedich-729	146	46	,	,	PUNCT
biomedich-729	146	47	2015	2015	NUM
biomedich-729	146	48	;	;	PUNCT
biomedich-729	146	49	mejia	mejia	PROPN
biomedich-729	146	50	et	et	PROPN
biomedich-729	146	51	al	al	PROPN
biomedich-729	146	52	.	.	PROPN
biomedich-729	146	53	,	,	PUNCT
biomedich-729	146	54	2020	2020	NUM
biomedich-729	146	55	;	;	PUNCT
biomedich-729	146	56	osuntokun	osuntokun	VERB
biomedich-729	146	57	et	et	NOUN
biomedich-729	146	58	al	al	PROPN
biomedich-729	146	59	.	.	PROPN
biomedich-729	146	60	,	,	PUNCT
biomedich-729	146	61	2020	2020	NUM
biomedich-729	146	62	)	)	PUNCT
biomedich-729	146	63	.	.	PUNCT
biomedich-729	147	1	the	the	DET
biomedich-729	147	2	high	high	ADJ
biomedich-729	147	3	potential	potential	NOUN
biomedich-729	147	4	for	for	ADP
biomedich-729	147	5	adverse	adverse	ADJ
biomedich-729	147	6	reactions	reaction	NOUN
biomedich-729	147	7	with	with	ADP
biomedich-729	147	8	the	the	DET
biomedich-729	147	9	use	use	NOUN
biomedich-729	147	10	of	of	ADP
biomedich-729	147	11	herbal	herbal	ADJ
biomedich-729	147	12	preparations	preparation	NOUN
biomedich-729	147	13	is	be	AUX
biomedich-729	147	14	attributable	attributable	ADJ
biomedich-729	147	15	to	to	ADP
biomedich-729	147	16	the	the	DET
biomedich-729	147	17	huge	huge	ADJ
biomedich-729	147	18	diversity	diversity	NOUN
biomedich-729	147	19	and	and	CCONJ
biomedich-729	147	20	the	the	DET
biomedich-729	147	21	numerical	numerical	ADJ
biomedich-729	147	22	enormity	enormity	NOUN
biomedich-729	147	23	of	of	ADP
biomedich-729	147	24	phytochemicals	phytochemical	NOUN
biomedich-729	147	25	that	that	PRON
biomedich-729	147	26	are	be	AUX
biomedich-729	147	27	consumed	consume	VERB
biomedich-729	147	28	at	at	ADP
biomedich-729	147	29	the	the	DET
biomedich-729	147	30	same	same	ADJ
biomedich-729	147	31	time	time	NOUN
biomedich-729	147	32	,	,	PUNCT
biomedich-729	147	33	and	and	CCONJ
biomedich-729	147	34	in	in	ADP
biomedich-729	147	35	most	most	ADJ
biomedich-729	147	36	cases	case	NOUN
biomedich-729	147	37	,	,	PUNCT
biomedich-729	147	38	in	in	ADP
biomedich-729	147	39	unstandardized	unstandardized	ADJ
biomedich-729	147	40	quantities	quantity	NOUN
biomedich-729	147	41	.	.	PUNCT
biomedich-729	148	1	with	with	ADP
biomedich-729	148	2	10	10	NUM
biomedich-729	148	3	components	component	NOUN
biomedich-729	148	4	of	of	ADP
biomedich-729	148	5	the	the	DET
biomedich-729	148	6	extract	extract	NOUN
biomedich-729	148	7	of	of	ADP
biomedich-729	148	8	c.	c.	PROPN
biomedich-729	148	9	rostrata	rostrata	PROPN
biomedich-729	148	10	epicarp	epicarp	ADJ
biomedich-729	148	11	possessing	possess	VERB
biomedich-729	148	12	the	the	DET
biomedich-729	148	13	ability	ability	NOUN
biomedich-729	148	14	to	to	PART
biomedich-729	148	15	induce	induce	VERB
biomedich-729	148	16	oxidative	oxidative	ADJ
biomedich-729	148	17	stress	stress	NOUN
biomedich-729	148	18	and	and	CCONJ
biomedich-729	148	19	initiate	initiate	VERB
biomedich-729	148	20	processes	process	NOUN
biomedich-729	148	21	leading	lead	VERB
biomedich-729	148	22	to	to	ADP
biomedich-729	148	23	loss	loss	NOUN
biomedich-729	148	24	of	of	ADP
biomedich-729	148	25	mitochondrial	mitochondrial	ADJ
biomedich-729	148	26	membrane	membrane	NOUN
biomedich-729	148	27	potential	potential	NOUN
biomedich-729	148	28	and	and	CCONJ
biomedich-729	148	29	massive	massive	ADJ
biomedich-729	148	30	apoptotic	apoptotic	ADJ
biomedich-729	148	31	cell	cell	NOUN
biomedich-729	148	32	death	death	NOUN
biomedich-729	148	33	;	;	PUNCT
biomedich-729	148	34	red	red	ADJ
biomedich-729	148	35	blood	blood	NOUN
biomedich-729	148	36	cells	cell	NOUN
biomedich-729	148	37	and	and	CCONJ
biomedich-729	148	38	brain	brain	NOUN
biomedich-729	148	39	cells	cell	NOUN
biomedich-729	148	40	which	which	PRON
biomedich-729	148	41	require	require	VERB
biomedich-729	148	42	a	a	DET
biomedich-729	148	43	high	high	ADJ
biomedich-729	148	44	level	level	NOUN
biomedich-729	148	45	of	of	ADP
biomedich-729	148	46	oxygen	oxygen	NOUN
biomedich-729	148	47	could	could	AUX
biomedich-729	148	48	be	be	AUX
biomedich-729	148	49	sites	site	NOUN
biomedich-729	148	50	for	for	ADP
biomedich-729	148	51	adverse	adverse	ADJ
biomedich-729	148	52	reactions	reaction	NOUN
biomedich-729	148	53	after	after	SCONJ
biomedich-729	148	54	the	the	DET
biomedich-729	148	55	extract	extract	NOUN
biomedich-729	148	56	is	be	AUX
biomedich-729	148	57	consumed	consume	VERB
biomedich-729	148	58	.	.	PUNCT
biomedich-729	149	1	gc	gc	PROPN
biomedich-729	149	2	-	-	PUNCT
biomedich-729	149	3	ms	ms	NOUN
biomedich-729	149	4	and	and	CCONJ
biomedich-729	149	5	toxicity	toxicity	NOUN
biomedich-729	149	6	analyses	analyse	VERB
biomedich-729	149	7	the	the	DET
biomedich-729	149	8	gc	gc	PROPN
biomedich-729	149	9	-	-	PUNCT
biomedich-729	149	10	ms	ms	NOUN
biomedich-729	149	11	analysis	analysis	NOUN
biomedich-729	149	12	of	of	ADP
biomedich-729	149	13	components	component	NOUN
biomedich-729	149	14	of	of	ADP
biomedich-729	149	15	ethanol	ethanol	NOUN
biomedich-729	149	16	extract	extract	NOUN
biomedich-729	149	17	of	of	ADP
biomedich-729	149	18	c.	c.	PROPN
biomedich-729	149	19	rostrata	rostrata	PROPN
biomedich-729	149	20	epicarp	epicarp	PROPN
biomedich-729	149	21	identified	identify	VERB
biomedich-729	149	22	48	48	NUM
biomedich-729	149	23	different	different	ADJ
biomedich-729	149	24	phytochemicals	phytochemical	NOUN
biomedich-729	149	25	.	.	PUNCT
biomedich-729	150	1	this	this	DET
biomedich-729	150	2	value	value	NOUN
biomedich-729	150	3	represents	represent	VERB
biomedich-729	150	4	the	the	DET
biomedich-729	150	5	components	component	NOUN
biomedich-729	150	6	of	of	ADP
biomedich-729	150	7	the	the	DET
biomedich-729	150	8	extract	extract	NOUN
biomedich-729	150	9	that	that	PRON
biomedich-729	150	10	are	be	AUX
biomedich-729	150	11	already	already	ADV
biomedich-729	150	12	known	know	VERB
biomedich-729	150	13	,	,	PUNCT
biomedich-729	150	14	but	but	CCONJ
biomedich-729	150	15	possible	possible	ADJ
biomedich-729	150	16	novel	novel	ADJ
biomedich-729	150	17	components	component	NOUN
biomedich-729	150	18	are	be	AUX
biomedich-729	150	19	not	not	PART
biomedich-729	150	20	accounted	account	VERB
biomedich-729	150	21	for	for	ADP
biomedich-729	150	22	,	,	PUNCT
biomedich-729	150	23	and	and	CCONJ
biomedich-729	150	24	the	the	DET
biomedich-729	150	25	possibility	possibility	NOUN
biomedich-729	150	26	of	of	ADP
biomedich-729	150	27	having	have	VERB
biomedich-729	150	28	these	these	DET
biomedich-729	150	29	unidentified	unidentified	ADJ
biomedich-729	150	30	components	component	NOUN
biomedich-729	150	31	contributing	contribute	VERB
biomedich-729	150	32	significantly	significantly	ADV
biomedich-729	150	33	to	to	ADP
biomedich-729	150	34	toxic	toxic	ADJ
biomedich-729	150	35	outcomes	outcome	NOUN
biomedich-729	150	36	can	can	AUX
biomedich-729	150	37	not	not	PART
biomedich-729	150	38	be	be	AUX
biomedich-729	150	39	ascertained	ascertain	VERB
biomedich-729	150	40	.	.	PUNCT
biomedich-729	151	1	the	the	DET
biomedich-729	151	2	high	high	ADJ
biomedich-729	151	3	potential	potential	NOUN
biomedich-729	151	4	of	of	ADP
biomedich-729	151	5	some	some	PRON
biomedich-729	151	6	of	of	ADP
biomedich-729	151	7	the	the	DET
biomedich-729	151	8	identified	identify	VERB
biomedich-729	151	9	components	component	NOUN
biomedich-729	151	10	of	of	ADP
biomedich-729	151	11	the	the	DET
biomedich-729	151	12	extract	extract	NOUN
biomedich-729	151	13	to	to	PART
biomedich-729	151	14	cause	cause	VERB
biomedich-729	151	15	liver	liver	NOUN
biomedich-729	151	16	damage	damage	NOUN
biomedich-729	151	17	relates	relate	VERB
biomedich-729	151	18	well	well	ADV
biomedich-729	151	19	with	with	ADP
biomedich-729	151	20	the	the	DET
biomedich-729	151	21	reported	report	VERB
biomedich-729	151	22	potential	potential	NOUN
biomedich-729	151	23	of	of	ADP
biomedich-729	151	24	the	the	DET
biomedich-729	151	25	extract	extract	NOUN
biomedich-729	151	26	for	for	ADP
biomedich-729	151	27	the	the	DET
biomedich-729	151	28	management	management	NOUN
biomedich-729	151	29	of	of	ADP
biomedich-729	151	30	pain	pain	NOUN
biomedich-729	151	31	and	and	CCONJ
biomedich-729	151	32	inflammation	inflammation	NOUN
biomedich-729	151	33	as	as	SCONJ
biomedich-729	151	34	many	many	ADJ
biomedich-729	151	35	non	non	ADJ
biomedich-729	151	36	-	-	ADJ
biomedich-729	151	37	steroidal	steroidal	ADJ
biomedich-729	151	38	antiinflammatory	antiinflammatory	NOUN
biomedich-729	151	39	drugs	drug	NOUN
biomedich-729	151	40	have	have	AUX
biomedich-729	151	41	also	also	ADV
biomedich-729	151	42	been	be	AUX
biomedich-729	151	43	reported	report	VERB
biomedich-729	151	44	to	to	PART
biomedich-729	151	45	cause	cause	VERB
biomedich-729	151	46	damage	damage	NOUN
biomedich-729	151	47	to	to	ADP
biomedich-729	151	48	the	the	DET
biomedich-729	151	49	liver	liver	NOUN
biomedich-729	151	50	.	.	PUNCT
biomedich-729	152	1	though	though	SCONJ
biomedich-729	152	2	the	the	DET
biomedich-729	152	3	inhibition	inhibition	NOUN
biomedich-729	152	4	of	of	ADP
biomedich-729	152	5	members	member	NOUN
biomedich-729	152	6	of	of	ADP
biomedich-729	152	7	cyp450	cyp450	NOUN
biomedich-729	152	8	enzyme	enzyme	NOUN
biomedich-729	152	9	family	family	NOUN
biomedich-729	152	10	has	have	AUX
biomedich-729	152	11	been	be	AUX
biomedich-729	152	12	identified	identify	VERB
biomedich-729	152	13	as	as	ADP
biomedich-729	152	14	having	have	VERB
biomedich-729	152	15	therapeutic	therapeutic	ADJ
biomedich-729	152	16	potential	potential	NOUN
biomedich-729	152	17	in	in	ADP
biomedich-729	152	18	some	some	DET
biomedich-729	152	19	disease	disease	NOUN
biomedich-729	152	20	conditions	condition	NOUN
biomedich-729	152	21	,	,	PUNCT
biomedich-729	152	22	largely	largely	ADV
biomedich-729	152	23	,	,	PUNCT
biomedich-729	152	24	their	their	PRON
biomedich-729	152	25	inhibition	inhibition	NOUN
biomedich-729	152	26	has	have	AUX
biomedich-729	152	27	been	be	AUX
biomedich-729	152	28	associated	associate	VERB
biomedich-729	152	29	with	with	ADP
biomedich-729	152	30	dangerously	dangerously	ADV
biomedich-729	152	31	toxic	toxic	ADJ
biomedich-729	152	32	outcomes	outcome	NOUN
biomedich-729	152	33	(	(	PUNCT
biomedich-729	152	34	alaei	alaei	X
biomedich-729	152	35	et	et	PROPN
biomedich-729	152	36	al	al	PROPN
biomedich-729	152	37	.	.	PROPN
biomedich-729	152	38	,	,	PUNCT
biomedich-729	152	39	2023	2023	NUM
biomedich-729	152	40	)	)	PUNCT
biomedich-729	152	41	.	.	PUNCT
biomedich-729	153	1	a	a	DET
biomedich-729	153	2	flavonoid	flavonoid	PROPN
biomedich-729	153	3	component	component	NOUN
biomedich-729	153	4	of	of	ADP
biomedich-729	153	5	the	the	DET
biomedich-729	153	6	extract	extract	NOUN
biomedich-729	153	7	,	,	PUNCT
biomedich-729	153	8	2hydroxychalcone	2hydroxychalcone	NUM
biomedich-729	153	9	,	,	PUNCT
biomedich-729	153	10	which	which	PRON
biomedich-729	153	11	binds	bind	VERB
biomedich-729	153	12	strongly	strongly	ADV
biomedich-729	153	13	to	to	ADP
biomedich-729	153	14	members	member	NOUN
biomedich-729	153	15	of	of	ADP
biomedich-729	153	16	cyp450	cyp450	NOUN
biomedich-729	153	17	family	family	NOUN
biomedich-729	153	18	,	,	PUNCT
biomedich-729	153	19	has	have	AUX
biomedich-729	153	20	been	be	AUX
biomedich-729	153	21	found	find	VERB
biomedich-729	153	22	to	to	PART
biomedich-729	153	23	inflict	inflict	VERB
biomedich-729	153	24	damage	damage	NOUN
biomedich-729	153	25	to	to	ADP
biomedich-729	153	26	hepatocytes	hepatocyte	NOUN
biomedich-729	153	27	at	at	ADP
biomedich-729	153	28	concentrations	concentration	NOUN
biomedich-729	153	29	above	above	ADP
biomedich-729	153	30	20	20	NUM
biomedich-729	153	31	µm	µm	NOUN
biomedich-729	153	32	through	through	ADP
biomedich-729	153	33	the	the	DET
biomedich-729	153	34	generation	generation	NOUN
biomedich-729	153	35	of	of	ADP
biomedich-729	153	36	oxidative	oxidative	ADJ
biomedich-729	153	37	stress	stress	NOUN
biomedich-729	153	38	and	and	CCONJ
biomedich-729	153	39	down	down	ADP
biomedich-729	153	40	-	-	PUNCT
biomedich-729	153	41	regulation	regulation	NOUN
biomedich-729	153	42	of	of	ADP
biomedich-729	153	43	the	the	DET
biomedich-729	153	44	expression	expression	NOUN
biomedich-729	153	45	of	of	ADP
biomedich-729	153	46	antioxidant	antioxidant	ADJ
biomedich-729	153	47	proteins	protein	NOUN
biomedich-729	153	48	in	in	ADP
biomedich-729	153	49	hepg2	hepg2	NOUN
biomedich-729	153	50	cells	cell	NOUN
biomedich-729	153	51	(	(	PUNCT
biomedich-729	153	52	qian	qian	PROPN
biomedich-729	153	53	et	et	PROPN
biomedich-729	153	54	al	al	PROPN
biomedich-729	153	55	.	.	PROPN
biomedich-729	153	56	,	,	PUNCT
biomedich-729	153	57	2019	2019	NUM
biomedich-729	153	58	)	)	PUNCT
biomedich-729	153	59	.	.	PUNCT
biomedich-729	154	1	2	2	NUM
biomedich-729	154	2	-	-	PUNCT
biomedich-729	154	3	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	154	4	which	which	PRON
biomedich-729	154	5	also	also	ADV
biomedich-729	154	6	interferes	interfere	VERB
biomedich-729	154	7	with	with	ADP
biomedich-729	154	8	nr	nr	NOUN
biomedich-729	154	9	-	-	ADJ
biomedich-729	154	10	ppar	ppar	NOUN
biomedich-729	154	11	-	-	PUNCT
biomedich-729	154	12	gamma	gamma	NOUN
biomedich-729	154	13	activity	activity	NOUN
biomedich-729	154	14	has	have	AUX
biomedich-729	154	15	been	be	AUX
biomedich-729	154	16	reported	report	VERB
biomedich-729	154	17	to	to	PART
biomedich-729	154	18	reduce	reduce	VERB
biomedich-729	154	19	hyperglycemia	hyperglycemia	NOUN
biomedich-729	154	20	through	through	ADP
biomedich-729	154	21	the	the	DET
biomedich-729	154	22	nr	nr	NOUN
biomedich-729	154	23	-	-	PUNCT
biomedich-729	154	24	ppar	ppar	NOUN
biomedich-729	154	25	-	-	PUNCT
biomedich-729	154	26	gamma	gamma	NOUN
biomedich-729	154	27	pathway	pathway	NOUN
biomedich-729	154	28	in	in	ADP
biomedich-729	154	29	diabetic	diabetic	ADJ
biomedich-729	154	30	rats	rat	NOUN
biomedich-729	154	31	(	(	PUNCT
biomedich-729	154	32	eissa	eissa	PROPN
biomedich-729	154	33	et	et	PROPN
biomedich-729	154	34	al	al	PROPN
biomedich-729	154	35	.	.	PROPN
biomedich-729	154	36	,	,	PUNCT
biomedich-729	154	37	2017	2017	NUM
biomedich-729	154	38	)	)	PUNCT
biomedich-729	154	39	.	.	PUNCT
biomedich-729	155	1	the	the	DET
biomedich-729	155	2	strong	strong	ADJ
biomedich-729	155	3	binding	binding	NOUN
biomedich-729	155	4	of	of	ADP
biomedich-729	155	5	2	2	NUM
biomedich-729	155	6	-	-	PUNCT
biomedich-729	155	7	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	155	8	to	to	ADP
biomedich-729	155	9	subunit	subunit	PROPN
biomedich-729	155	10	b	b	PROPN
biomedich-729	155	11	of	of	ADP
biomedich-729	155	12	na+/k+atpase	na+/k+atpase	NUM
biomedich-729	155	13	,	,	PUNCT
biomedich-729	155	14	which	which	PRON
biomedich-729	155	15	involves	involve	VERB
biomedich-729	155	16	hydrophobic	hydrophobic	NOUN
biomedich-729	155	17	interactions	interaction	NOUN
biomedich-729	155	18	and	and	CCONJ
biomedich-729	155	19	conventional	conventional	ADJ
biomedich-729	155	20	strong	strong	ADJ
biomedich-729	155	21	hydrogen	hydrogen	NOUN
biomedich-729	155	22	bonding	bonding	NOUN
biomedich-729	155	23	,	,	PUNCT
biomedich-729	155	24	shows	show	VERB
biomedich-729	155	25	that	that	SCONJ
biomedich-729	155	26	the	the	DET
biomedich-729	155	27	compound	compound	NOUN
biomedich-729	155	28	could	could	AUX
biomedich-729	155	29	be	be	AUX
biomedich-729	155	30	a	a	DET
biomedich-729	155	31	strong	strong	ADJ
biomedich-729	155	32	inhibitor	inhibitor	NOUN
biomedich-729	155	33	of	of	ADP
biomedich-729	155	34	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	155	35	.	.	PUNCT
biomedich-729	156	1	na+/k+-atpase	na+/k+-atpase	ADJ
biomedich-729	156	2	inhibitors	inhibitor	NOUN
biomedich-729	156	3	,	,	PUNCT
biomedich-729	156	4	like	like	ADP
biomedich-729	156	5	cardiac	cardiac	ADJ
biomedich-729	156	6	glycosides	glycoside	NOUN
biomedich-729	156	7	(	(	PUNCT
biomedich-729	156	8	e.g.	e.g.	ADV
biomedich-729	156	9	,	,	PUNCT
biomedich-729	156	10	digoxin	digoxin	NOUN
biomedich-729	156	11	)	)	PUNCT
biomedich-729	156	12	,	,	PUNCT
biomedich-729	156	13	are	be	AUX
biomedich-729	156	14	clinically	clinically	ADV
biomedich-729	156	15	used	use	VERB
biomedich-729	156	16	to	to	PART
biomedich-729	156	17	enhance	enhance	VERB
biomedich-729	156	18	cardiac	cardiac	ADJ
biomedich-729	156	19	contractility	contractility	NOUN
biomedich-729	156	20	as	as	SCONJ
biomedich-729	156	21	they	they	PRON
biomedich-729	156	22	regulate	regulate	VERB
biomedich-729	156	23	ion	ion	NOUN
biomedich-729	156	24	balance	balance	NOUN
biomedich-729	156	25	across	across	ADP
biomedich-729	156	26	the	the	DET
biomedich-729	156	27	plasma	plasma	NOUN
biomedich-729	156	28	membrane	membrane	NOUN
biomedich-729	156	29	especially	especially	ADV
biomedich-729	156	30	in	in	ADP
biomedich-729	156	31	neurons	neuron	NOUN
biomedich-729	156	32	and	and	CCONJ
biomedich-729	156	33	muscle	muscle	NOUN
biomedich-729	156	34	cells	cell	NOUN
biomedich-729	156	35	(	(	PUNCT
biomedich-729	156	36	ren	ren	NOUN
biomedich-729	156	37	et	et	PROPN
biomedich-729	156	38	al	al	PROPN
biomedich-729	156	39	,	,	PUNCT
biomedich-729	156	40	2024	2024	NUM
biomedich-729	156	41	)	)	PUNCT
biomedich-729	156	42	.	.	PUNCT
biomedich-729	157	1	2	2	X
biomedich-729	157	2	-	-	PUNCT
biomedich-729	157	3	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	157	4	could	could	AUX
biomedich-729	157	5	alter	alter	VERB
biomedich-729	157	6	ion	ion	NOUN
biomedich-729	157	7	transport	transport	NOUN
biomedich-729	157	8	,	,	PUNCT
biomedich-729	157	9	which	which	PRON
biomedich-729	157	10	has	have	VERB
biomedich-729	157	11	implications	implication	NOUN
biomedich-729	157	12	for	for	ADP
biomedich-729	157	13	conditions	condition	NOUN
biomedich-729	157	14	such	such	ADJ
biomedich-729	157	15	as	as	ADP
biomedich-729	157	16	hypertension	hypertension	NOUN
biomedich-729	157	17	,	,	PUNCT
biomedich-729	157	18	heart	heart	NOUN
biomedich-729	157	19	failure	failure	NOUN
biomedich-729	157	20	,	,	PUNCT
biomedich-729	157	21	or	or	CCONJ
biomedich-729	157	22	neuronal	neuronal	ADJ
biomedich-729	157	23	excitability	excitability	NOUN
biomedich-729	157	24	,	,	PUNCT
biomedich-729	157	25	thereby	thereby	ADV
biomedich-729	157	26	offering	offer	VERB
biomedich-729	157	27	potential	potential	NOUN
biomedich-729	157	28	as	as	ADP
biomedich-729	157	29	a	a	DET
biomedich-729	157	30	cardioprotective	cardioprotective	ADJ
biomedich-729	157	31	agent	agent	NOUN
biomedich-729	157	32	.	.	PUNCT
biomedich-729	158	1	the	the	DET
biomedich-729	158	2	toxic	toxic	ADJ
biomedich-729	158	3	effect	effect	NOUN
biomedich-729	158	4	of	of	ADP
biomedich-729	158	5	1-(4	1-(4	NOUN
biomedich-729	158	6	-	-	PUNCT
biomedich-729	158	7	methoxyphenylazo)-2phenoxynaphthalene	methoxyphenylazo)-2phenoxynaphthalene	NOUN
biomedich-729	158	8	which	which	PRON
biomedich-729	158	9	is	be	AUX
biomedich-729	158	10	shown	show	VERB
biomedich-729	158	11	here	here	ADV
biomedich-729	158	12	to	to	PART
biomedich-729	158	13	bind	bind	VERB
biomedich-729	158	14	strongly	strongly	ADV
biomedich-729	158	15	to	to	ADP
biomedich-729	158	16	members	member	NOUN
biomedich-729	158	17	of	of	ADP
biomedich-729	158	18	cyp450	cyp450	NOUN
biomedich-729	158	19	family	family	NOUN
biomedich-729	158	20	and	and	CCONJ
biomedich-729	158	21	also	also	ADV
biomedich-729	158	22	to	to	ADP
biomedich-729	158	23	subunits	subunit	NOUN
biomedich-729	158	24	in	in	ADP
biomedich-729	158	25	nadh	nadh	NOUN
biomedich-729	158	26	dehydrogenase	dehydrogenase	NOUN
biomedich-729	158	27	1	1	NUM
biomedich-729	158	28	has	have	AUX
biomedich-729	158	29	not	not	PART
biomedich-729	158	30	been	be	AUX
biomedich-729	158	31	reported	report	VERB
biomedich-729	158	32	in	in	ADP
biomedich-729	158	33	the	the	DET
biomedich-729	158	34	literature	literature	NOUN
biomedich-729	158	35	.	.	PUNCT
biomedich-729	159	1	the	the	DET
biomedich-729	159	2	inhibition	inhibition	NOUN
biomedich-729	159	3	of	of	ADP
biomedich-729	159	4	mitochondrial	mitochondrial	ADJ
biomedich-729	159	5	nadh	nadh	NOUN
biomedich-729	159	6	dehydrogenase	dehydrogenase	NOUN
biomedich-729	159	7	1	1	NUM
biomedich-729	159	8	has	have	AUX
biomedich-729	159	9	been	be	AUX
biomedich-729	159	10	reported	report	VERB
biomedich-729	159	11	to	to	PART
biomedich-729	159	12	induce	induce	VERB
biomedich-729	159	13	significant	significant	ADJ
biomedich-729	159	14	reactive	reactive	ADJ
biomedich-729	159	15	oxygen	oxygen	NOUN
biomedich-729	159	16	species	species	NOUN
biomedich-729	159	17	generation	generation	NOUN
biomedich-729	159	18	which	which	PRON
biomedich-729	159	19	have	have	VERB
biomedich-729	159	20	toxic	toxic	ADJ
biomedich-729	159	21	outcomes	outcome	NOUN
biomedich-729	159	22	in	in	ADP
biomedich-729	159	23	the	the	DET
biomedich-729	159	24	liver	liver	NOUN
biomedich-729	159	25	and	and	CCONJ
biomedich-729	159	26	the	the	DET
biomedich-729	159	27	brain	brain	NOUN
biomedich-729	159	28	(	(	PUNCT
biomedich-729	159	29	murali	murali	PROPN
biomedich-729	159	30	&	&	CCONJ
biomedich-729	159	31	shivanandappa	shivanandappa	PROPN
biomedich-729	159	32	,	,	PUNCT
biomedich-729	159	33	2022	2022	NUM
biomedich-729	159	34	)	)	PUNCT
biomedich-729	159	35	.	.	PUNCT
biomedich-729	160	1	the	the	DET
biomedich-729	160	2	inhibition	inhibition	NOUN
biomedich-729	160	3	of	of	ADP
biomedich-729	160	4	nadh	nadh	NOUN
biomedich-729	160	5	dehydrogenase	dehydrogenase	NOUN
biomedich-729	160	6	1	1	NUM
biomedich-729	160	7	in	in	ADP
biomedich-729	160	8	the	the	DET
biomedich-729	160	9	mitochondria	mitochondria	NOUN
biomedich-729	160	10	by	by	ADP
biomedich-729	160	11	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	160	12	-	-	PUNCT
biomedich-729	160	13	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	160	14	may	may	AUX
biomedich-729	160	15	be	be	AUX
biomedich-729	160	16	one	one	NUM
biomedich-729	160	17	of	of	ADP
biomedich-729	160	18	the	the	DET
biomedich-729	160	19	significant	significant	ADJ
biomedich-729	160	20	contributors	contributor	NOUN
biomedich-729	160	21	to	to	ADP
biomedich-729	160	22	the	the	DET
biomedich-729	160	23	cytotoxicity	cytotoxicity	NOUN
biomedich-729	160	24	of	of	ADP
biomedich-729	160	25	c.	c.	PROPN
biomedich-729	160	26	rostrata	rostrata	PROPN
biomedich-729	160	27	epicarp	epicarp	ADJ
biomedich-729	160	28	extract	extract	VERB
biomedich-729	160	29	against	against	ADP
biomedich-729	160	30	hela	hela	PROPN
biomedich-729	160	31	and	and	CCONJ
biomedich-729	160	32	mrc5	mrc5	NOUN
biomedich-729	160	33	-	-	PUNCT
biomedich-729	160	34	sv2	sv2	NOUN
biomedich-729	160	35	cells	cell	NOUN
biomedich-729	160	36	.	.	PUNCT
biomedich-729	161	1	this	this	PRON
biomedich-729	161	2	also	also	ADV
biomedich-729	161	3	suggests	suggest	VERB
biomedich-729	161	4	that	that	SCONJ
biomedich-729	161	5	cola	cola	PROPN
biomedich-729	161	6	rostrata	rostrata	NOUN
biomedich-729	161	7	extract	extract	NOUN
biomedich-729	161	8	might	might	AUX
biomedich-729	161	9	be	be	AUX
biomedich-729	161	10	able	able	ADJ
biomedich-729	161	11	to	to	PART
biomedich-729	161	12	modulate	modulate	VERB
biomedich-729	161	13	energy	energy	NOUN
biomedich-729	161	14	metabolism	metabolism	NOUN
biomedich-729	161	15	,	,	PUNCT
biomedich-729	161	16	potentially	potentially	ADV
biomedich-729	161	17	leading	lead	VERB
biomedich-729	161	18	to	to	ADP
biomedich-729	161	19	therapeutic	therapeutic	ADJ
biomedich-729	161	20	applications	application	NOUN
biomedich-729	161	21	in	in	ADP
biomedich-729	161	22	cancer	cancer	NOUN
biomedich-729	161	23	cells	cell	NOUN
biomedich-729	161	24	,	,	PUNCT
biomedich-729	161	25	or	or	CCONJ
biomedich-729	161	26	side	side	NOUN
biomedich-729	161	27	effects	effect	NOUN
biomedich-729	161	28	if	if	SCONJ
biomedich-729	161	29	inhibition	inhibition	NOUN
biomedich-729	161	30	of	of	ADP
biomedich-729	161	31	this	this	DET
biomedich-729	161	32	enzyme	enzyme	NOUN
biomedich-729	161	33	occurs	occur	VERB
biomedich-729	161	34	in	in	ADP
biomedich-729	161	35	healthy	healthy	ADJ
biomedich-729	161	36	cells	cell	NOUN
biomedich-729	161	37	.	.	PUNCT
biomedich-729	162	1	the	the	DET
biomedich-729	162	2	inhibition	inhibition	NOUN
biomedich-729	162	3	of	of	ADP
biomedich-729	162	4	cyp2c19	cyp2c19	NOUN
biomedich-729	162	5	by	by	ADP
biomedich-729	162	6	1-(4methoxyphenylazo)-2	1-(4methoxyphenylazo)-2	NOUN
biomedich-729	162	7	-	-	PUNCT
biomedich-729	162	8	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	162	9	may	may	AUX
biomedich-729	162	10	invariably	invariably	ADV
biomedich-729	162	11	result	result	VERB
biomedich-729	162	12	in	in	ADP
biomedich-729	162	13	altered	altered	ADJ
biomedich-729	162	14	drug	drug	NOUN
biomedich-729	162	15	metabolism	metabolism	NOUN
biomedich-729	162	16	,	,	PUNCT
biomedich-729	162	17	potentially	potentially	ADV
biomedich-729	162	18	affecting	affect	VERB
biomedich-729	162	19	the	the	DET
biomedich-729	162	20	pharmacokinetics	pharmacokinetic	NOUN
biomedich-729	162	21	of	of	ADP
biomedich-729	162	22	drugs	drug	NOUN
biomedich-729	162	23	metabolized	metabolize	VERB
biomedich-729	162	24	by	by	ADP
biomedich-729	162	25	this	this	DET
biomedich-729	162	26	enzyme	enzyme	NOUN
biomedich-729	162	27	.	.	PUNCT
biomedich-729	163	1	the	the	DET
biomedich-729	163	2	resulting	result	VERB
biomedich-729	163	3	modulation	modulation	NOUN
biomedich-729	163	4	might	might	AUX
biomedich-729	163	5	be	be	AUX
biomedich-729	163	6	harnessed	harness	VERB
biomedich-729	163	7	for	for	ADP
biomedich-729	163	8	controlling	control	VERB
biomedich-729	163	9	drug	drug	NOUN
biomedich-729	163	10	metabolism	metabolism	NOUN
biomedich-729	163	11	in	in	ADP
biomedich-729	163	12	individuals	individual	NOUN
biomedich-729	163	13	with	with	ADP
biomedich-729	163	14	cyp2c19	cyp2c19	NOUN
biomedich-729	163	15	-	-	PUNCT
biomedich-729	163	16	specific	specific	ADJ
biomedich-729	163	17	health	health	NOUN
biomedich-729	163	18	issues	issue	NOUN
biomedich-729	163	19	.	.	PUNCT
biomedich-729	164	1	the	the	DET
biomedich-729	164	2	pharmacological	pharmacological	ADJ
biomedich-729	164	3	activity	activity	NOUN
biomedich-729	164	4	of	of	ADP
biomedich-729	164	5	anthiaergostan5,7,9	anthiaergostan5,7,9	NOUN
biomedich-729	164	6	-	-	PUNCT
biomedich-729	164	7	trien-14.alpha	trien-14.alpha	PROPN
biomedich-729	164	8	.	.	PUNCT
biomedich-729	164	9	,15.alpha.-diol	,15.alpha.-diol	PUNCT
biomedich-729	164	10	,	,	PUNCT
biomedich-729	164	11	which	which	PRON
biomedich-729	164	12	is	be	AUX
biomedich-729	164	13	one	one	NUM
biomedich-729	164	14	of	of	ADP
biomedich-729	164	15	these	these	DET
biomedich-729	164	16	10	10	NUM
biomedich-729	164	17	components	component	NOUN
biomedich-729	164	18	,	,	PUNCT
biomedich-729	164	19	in	in	ADP
biomedich-729	164	20	living	living	NOUN
biomedich-729	164	21	systems	system	NOUN
biomedich-729	164	22	has	have	AUX
biomedich-729	164	23	not	not	PART
biomedich-729	164	24	been	be	AUX
biomedich-729	164	25	fully	fully	ADV
biomedich-729	164	26	elucidated	elucidated	ADJ
biomedich-729	164	27	.	.	PUNCT
biomedich-729	165	1	here	here	ADV
biomedich-729	165	2	,	,	PUNCT
biomedich-729	165	3	the	the	DET
biomedich-729	165	4	molecular	molecular	ADJ
biomedich-729	165	5	docking	docking	NOUN
biomedich-729	165	6	experiments	experiment	NOUN
biomedich-729	165	7	revealed	reveal	VERB
biomedich-729	165	8	that	that	SCONJ
biomedich-729	165	9	the	the	DET
biomedich-729	165	10	compound	compound	NOUN
biomedich-729	165	11	binds	bind	VERB
biomedich-729	165	12	tightly	tightly	ADV
biomedich-729	165	13	to	to	ADP
biomedich-729	165	14	members	member	NOUN
biomedich-729	165	15	of	of	ADP
biomedich-729	165	16	the	the	DET
biomedich-729	165	17	cyp450	cyp450	NOUN
biomedich-729	165	18	family	family	NOUN
biomedich-729	165	19	and	and	CCONJ
biomedich-729	165	20	also	also	ADV
biomedich-729	165	21	to	to	PART
biomedich-729	165	22	nadh	nadh	VERB
biomedich-729	165	23	dehydrogenase	dehydrogenase	NOUN
biomedich-729	165	24	1	1	NUM
biomedich-729	165	25	.	.	PUNCT
biomedich-729	166	1	the	the	DET
biomedich-729	166	2	short	short	ADJ
biomedich-729	166	3	hydrogen	hydrogen	NOUN
biomedich-729	166	4	bond	bond	NOUN
biomedich-729	166	5	lengths	length	NOUN
biomedich-729	166	6	(	(	PUNCT
biomedich-729	166	7	2.5–2.9	2.5–2.9	NUM
biomedich-729	166	8	å	å	X
biomedich-729	166	9	)	)	PUNCT
biomedich-729	166	10	indicate	indicate	VERB
biomedich-729	166	11	strong	strong	ADJ
biomedich-729	166	12	binding	binding	ADJ
biomedich-729	166	13	affinity	affinity	NOUN
biomedich-729	166	14	,	,	PUNCT
biomedich-729	166	15	while	while	SCONJ
biomedich-729	166	16	hydrophobic	hydrophobic	NOUN
biomedich-729	166	17	interactions	interaction	NOUN
biomedich-729	166	18	stabilize	stabilize	VERB
biomedich-729	166	19	the	the	DET
biomedich-729	166	20	ligands	ligand	NOUN
biomedich-729	166	21	within	within	ADP
biomedich-729	166	22	enzyme	enzyme	NOUN
biomedich-729	166	23	pockets	pocket	NOUN
biomedich-729	166	24	.	.	PUNCT
biomedich-729	167	1	the	the	DET
biomedich-729	167	2	molecular	molecular	ADJ
biomedich-729	167	3	interactions	interaction	NOUN
biomedich-729	167	4	of	of	ADP
biomedich-729	167	5	cola	cola	NOUN
biomedich-729	167	6	rostrata	rostrata	NOUN
biomedich-729	167	7	components	component	NOUN
biomedich-729	167	8	with	with	ADP
biomedich-729	167	9	enzymes	enzyme	NOUN
biomedich-729	167	10	such	such	ADJ
biomedich-729	167	11	as	as	ADP
biomedich-729	167	12	nadh	nadh	NOUN
biomedich-729	167	13	dehydrogenase	dehydrogenase	NOUN
biomedich-729	167	14	,	,	PUNCT
biomedich-729	167	15	cyp1a1	cyp1a1	PROPN
biomedich-729	167	16	,	,	PUNCT
biomedich-729	167	17	cyp2c19	cyp2c19	PROPN
biomedich-729	167	18	,	,	PUNCT
biomedich-729	167	19	and	and	CCONJ
biomedich-729	167	20	na+/k+-atpase	na+/k+-atpase	NOUN
biomedich-729	167	21	demonstrate	demonstrate	VERB
biomedich-729	167	22	their	their	PRON
biomedich-729	167	23	potential	potential	NOUN
biomedich-729	167	24	to	to	PART
biomedich-729	167	25	modulate	modulate	VERB
biomedich-729	167	26	key	key	ADJ
biomedich-729	167	27	biological	biological	ADJ
biomedich-729	167	28	pathways	pathway	NOUN
biomedich-729	167	29	which	which	PRON
biomedich-729	167	30	could	could	AUX
biomedich-729	167	31	result	result	VERB
biomedich-729	167	32	in	in	ADP
biomedich-729	167	33	toxic	toxic	ADJ
biomedich-729	167	34	outcomes	outcome	NOUN
biomedich-729	167	35	.	.	PUNCT
biomedich-729	168	1	the	the	DET
biomedich-729	168	2	antioxidant	antioxidant	ADJ
biomedich-729	168	3	effects	effect	NOUN
biomedich-729	168	4	of	of	ADP
biomedich-729	168	5	phytosterol	phytosterol	NOUN
biomedich-729	168	6	constituents	constituent	NOUN
biomedich-729	168	7	could	could	AUX
biomedich-729	168	8	counter	counter	VERB
biomedich-729	168	9	toxicity	toxicity	NOUN
biomedich-729	168	10	the	the	DET
biomedich-729	168	11	toxic	toxic	ADJ
biomedich-729	168	12	effects	effect	NOUN
biomedich-729	168	13	of	of	ADP
biomedich-729	168	14	the	the	DET
biomedich-729	168	15	identified	identify	VERB
biomedich-729	168	16	components	component	NOUN
biomedich-729	168	17	of	of	ADP
biomedich-729	168	18	c.	c.	PROPN
biomedich-729	168	19	rostrata	rostrata	PROPN
biomedich-729	168	20	epicarp	epicarp	ADJ
biomedich-729	168	21	extract	extract	NOUN
biomedich-729	168	22	could	could	AUX
biomedich-729	168	23	be	be	AUX
biomedich-729	168	24	ameliorated	ameliorate	VERB
biomedich-729	168	25	by	by	ADP
biomedich-729	168	26	the	the	DET
biomedich-729	168	27	rich	rich	ADJ
biomedich-729	168	28	presence	presence	NOUN
biomedich-729	168	29	of	of	ADP
biomedich-729	168	30	phytosterols	phytosterol	NOUN
biomedich-729	168	31	like	like	ADP
biomedich-729	168	32	stigmasterol	stigmasterol	NOUN
biomedich-729	168	33	,	,	PUNCT
biomedich-729	168	34	β	β	NOUN
biomedich-729	168	35	-	-	NOUN
biomedich-729	168	36	sitosterol	sitosterol	NOUN
biomedich-729	168	37	,	,	PUNCT
biomedich-729	168	38	γ	γ	PROPN
biomedich-729	168	39	-	-	PUNCT
biomedich-729	168	40	sitosterol	sitosterol	NOUN
biomedich-729	168	41	and	and	CCONJ
biomedich-729	168	42	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	168	43	-	-	PUNCT
biomedich-729	168	44	diene	diene	NOUN
biomedich-729	168	45	in	in	ADP
biomedich-729	168	46	the	the	DET
biomedich-729	168	47	extract	extract	NOUN
biomedich-729	168	48	.	.	PUNCT
biomedich-729	169	1	these	these	DET
biomedich-729	169	2	phytosterols	phytosterol	NOUN
biomedich-729	169	3	have	have	AUX
biomedich-729	169	4	been	be	AUX
biomedich-729	169	5	shown	show	VERB
biomedich-729	169	6	to	to	PART
biomedich-729	169	7	possess	possess	VERB
biomedich-729	169	8	strong	strong	ADJ
biomedich-729	169	9	oxidative	oxidative	ADJ
biomedich-729	169	10	stress	stress	NOUN
biomedich-729	169	11	-	-	PUNCT
biomedich-729	169	12	combating	combat	VERB
biomedich-729	169	13	activities	activity	NOUN
biomedich-729	169	14	.	.	PUNCT
biomedich-729	170	1	koc	koc	PROPN
biomedich-729	170	2	et	et	PROPN
biomedich-729	170	3	al	al	PROPN
biomedich-729	170	4	(	(	PUNCT
biomedich-729	170	5	2021	2021	NUM
biomedich-729	170	6	)	)	PUNCT
biomedich-729	170	7	reported	report	VERB
biomedich-729	170	8	that	that	SCONJ
biomedich-729	170	9	β	β	NOUN
biomedich-729	170	10	-	-	PUNCT
biomedich-729	170	11	sitosterol	sitosterol	NOUN
biomedich-729	170	12	showed	show	VERB
biomedich-729	170	13	anti	anti	ADJ
biomedich-729	170	14	-	-	ADJ
biomedich-729	170	15	inflammatory	inflammatory	ADJ
biomedich-729	170	16	and	and	CCONJ
biomedich-729	170	17	anti	anti	ADJ
biomedich-729	170	18	-	-	ADJ
biomedich-729	170	19	oxidative	oxidative	ADJ
biomedich-729	170	20	stress	stress	NOUN
biomedich-729	170	21	activities	activity	NOUN
biomedich-729	170	22	in	in	ADP
biomedich-729	170	23	rats	rat	NOUN
biomedich-729	170	24	by	by	ADP
biomedich-729	170	25	increasing	increase	VERB
biomedich-729	170	26	the	the	DET
biomedich-729	170	27	378	378	NUM
biomedich-729	170	28	biology	biology	NOUN
biomedich-729	170	29	,	,	PUNCT
biomedich-729	170	30	medicine	medicine	NOUN
biomedich-729	170	31	,	,	PUNCT
biomedich-729	170	32	&	&	CCONJ
biomedich-729	170	33	natural	natural	ADJ
biomedich-729	170	34	product	product	NOUN
biomedich-729	170	35	chemistry	chemistry	NOUN
biomedich-729	170	36	14	14	NUM
biomedich-729	170	37	(	(	PUNCT
biomedich-729	170	38	1	1	NUM
biomedich-729	170	39	)	)	PUNCT
biomedich-729	170	40	,	,	PUNCT
biomedich-729	170	41	2025	2025	NUM
biomedich-729	170	42	:	:	PUNCT
biomedich-729	170	43	369	369	NUM
biomedich-729	170	44	-	-	SYM
biomedich-729	170	45	379	379	NUM
biomedich-729	170	46	activities	activity	NOUN
biomedich-729	170	47	of	of	ADP
biomedich-729	170	48	glutathione	glutathione	NOUN
biomedich-729	170	49	and	and	CCONJ
biomedich-729	170	50	the	the	DET
biomedich-729	170	51	antioxidant	antioxidant	ADJ
biomedich-729	170	52	enzyme	enzyme	NOUN
biomedich-729	170	53	,	,	PUNCT
biomedich-729	170	54	superoxide	superoxide	NOUN
biomedich-729	170	55	dismutase	dismutase	NOUN
biomedich-729	170	56	,	,	PUNCT
biomedich-729	170	57	while	while	SCONJ
biomedich-729	170	58	it	it	PRON
biomedich-729	170	59	also	also	ADV
biomedich-729	170	60	downregulated	downregulate	VERB
biomedich-729	170	61	the	the	DET
biomedich-729	170	62	levels	level	NOUN
biomedich-729	170	63	of	of	ADP
biomedich-729	170	64	inflammatory	inflammatory	ADJ
biomedich-729	170	65	proteins	protein	NOUN
biomedich-729	170	66	,	,	PUNCT
biomedich-729	170	67	tumor	tumor	NOUN
biomedich-729	170	68	necrosis	necrosis	NOUN
biomedich-729	170	69	factoralpha	factoralpha	NOUN
biomedich-729	170	70	and	and	CCONJ
biomedich-729	170	71	interleukin-6	interleukin-6	NOUN
biomedich-729	170	72	.	.	PUNCT
biomedich-729	171	1	the	the	DET
biomedich-729	171	2	analgesic	analgesic	ADJ
biomedich-729	171	3	and	and	CCONJ
biomedich-729	171	4	antiinflammatory	antiinflammatory	NOUN
biomedich-729	171	5	activity	activity	NOUN
biomedich-729	171	6	of	of	ADP
biomedich-729	171	7	stigmasterol	stigmasterol	NOUN
biomedich-729	171	8	was	be	AUX
biomedich-729	171	9	reported	report	VERB
biomedich-729	171	10	by	by	ADP
biomedich-729	171	11	kariuki	kariuki	PROPN
biomedich-729	171	12	et	et	PROPN
biomedich-729	171	13	al	al	PROPN
biomedich-729	171	14	(	(	PUNCT
biomedich-729	171	15	2012	2012	NUM
biomedich-729	171	16	)	)	PUNCT
biomedich-729	171	17	,	,	PUNCT
biomedich-729	171	18	and	and	CCONJ
biomedich-729	171	19	the	the	DET
biomedich-729	171	20	strong	strong	ADJ
biomedich-729	171	21	antioxidant	antioxidant	ADJ
biomedich-729	171	22	potential	potential	NOUN
biomedich-729	171	23	of	of	ADP
biomedich-729	171	24	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	171	25	-	-	PUNCT
biomedich-729	171	26	dien-3	dien-3	NOUN
biomedich-729	171	27	-	-	PUNCT
biomedich-729	171	28	one	one	NOUN
biomedich-729	171	29	,	,	PUNCT
biomedich-729	171	30	a	a	DET
biomedich-729	171	31	closely	closely	ADV
biomedich-729	171	32	related	relate	VERB
biomedich-729	171	33	compound	compound	NOUN
biomedich-729	171	34	to	to	ADP
biomedich-729	171	35	stigmasta-4,22	stigmasta-4,22	NOUN
biomedich-729	171	36	-	-	PUNCT
biomedich-729	171	37	diene	diene	NOUN
biomedich-729	171	38	,	,	PUNCT
biomedich-729	171	39	was	be	AUX
biomedich-729	171	40	reported	report	VERB
biomedich-729	171	41	by	by	ADP
biomedich-729	171	42	sahidin	sahidin	VERB
biomedich-729	171	43	et	et	PROPN
biomedich-729	171	44	al	al	PROPN
biomedich-729	171	45	(	(	PUNCT
biomedich-729	171	46	2014	2014	NUM
biomedich-729	171	47	)	)	PUNCT
biomedich-729	171	48	.	.	PUNCT
biomedich-729	172	1	the	the	DET
biomedich-729	172	2	overall	overall	ADJ
biomedich-729	172	3	toxicity	toxicity	NOUN
biomedich-729	172	4	of	of	ADP
biomedich-729	172	5	the	the	DET
biomedich-729	172	6	ethanol	ethanol	NOUN
biomedich-729	172	7	extract	extract	NOUN
biomedich-729	172	8	of	of	ADP
biomedich-729	172	9	c.	c.	PROPN
biomedich-729	172	10	rostrata	rostrata	PROPN
biomedich-729	172	11	epicarp	epicarp	ADJ
biomedich-729	172	12	could	could	AUX
biomedich-729	172	13	be	be	AUX
biomedich-729	172	14	reduced	reduce	VERB
biomedich-729	172	15	by	by	ADP
biomedich-729	172	16	the	the	DET
biomedich-729	172	17	presence	presence	NOUN
biomedich-729	172	18	of	of	ADP
biomedich-729	172	19	these	these	DET
biomedich-729	172	20	steroids	steroid	NOUN
biomedich-729	172	21	.	.	PUNCT
biomedich-729	173	1	conclusion	conclusion	NOUN
biomedich-729	173	2	this	this	DET
biomedich-729	173	3	study	study	NOUN
biomedich-729	173	4	provides	provide	VERB
biomedich-729	173	5	analyses	analysis	NOUN
biomedich-729	173	6	of	of	ADP
biomedich-729	173	7	the	the	DET
biomedich-729	173	8	pharmacological	pharmacological	ADJ
biomedich-729	173	9	and	and	CCONJ
biomedich-729	173	10	toxicological	toxicological	ADJ
biomedich-729	173	11	profiles	profile	NOUN
biomedich-729	173	12	of	of	ADP
biomedich-729	173	13	components	component	NOUN
biomedich-729	173	14	of	of	ADP
biomedich-729	173	15	the	the	DET
biomedich-729	173	16	ethanol	ethanol	NOUN
biomedich-729	173	17	extract	extract	NOUN
biomedich-729	173	18	from	from	ADP
biomedich-729	173	19	the	the	DET
biomedich-729	173	20	epicarp	epicarp	NOUN
biomedich-729	173	21	of	of	ADP
biomedich-729	173	22	cola	cola	PROPN
biomedich-729	173	23	rostrata	rostrata	NOUN
biomedich-729	173	24	fruit	fruit	NOUN
biomedich-729	173	25	.	.	PUNCT
biomedich-729	174	1	the	the	DET
biomedich-729	174	2	extract	extract	NOUN
biomedich-729	174	3	contains	contain	VERB
biomedich-729	174	4	48	48	NUM
biomedich-729	174	5	identified	identify	VERB
biomedich-729	174	6	phytochemicals	phytochemical	NOUN
biomedich-729	174	7	,	,	PUNCT
biomedich-729	174	8	including	include	VERB
biomedich-729	174	9	1-(4	1-(4	NUM
biomedich-729	174	10	-	-	PUNCT
biomedich-729	174	11	methoxyphenylazo)-2	methoxyphenylazo)-2	NOUN
biomedich-729	174	12	-	-	PUNCT
biomedich-729	174	13	phenoxynaphthalene	phenoxynaphthalene	NOUN
biomedich-729	174	14	,	,	PUNCT
biomedich-729	174	15	anthiaergostan-5,7,9	anthiaergostan-5,7,9	NOUN
biomedich-729	174	16	-	-	PUNCT
biomedich-729	174	17	trien-14.alpha,15.alpha.-diol	trien-14.alpha,15.alpha.-diol	NOUN
biomedich-729	174	18	,	,	PUNCT
biomedich-729	174	19	and	and	CCONJ
biomedich-729	174	20	2	2	X
biomedich-729	174	21	-	-	PUNCT
biomedich-729	174	22	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	174	23	,	,	PUNCT
biomedich-729	174	24	which	which	PRON
biomedich-729	174	25	were	be	AUX
biomedich-729	174	26	evaluated	evaluate	VERB
biomedich-729	174	27	for	for	ADP
biomedich-729	174	28	their	their	PRON
biomedich-729	174	29	metabolism	metabolism	NOUN
biomedich-729	174	30	,	,	PUNCT
biomedich-729	174	31	excretion	excretion	NOUN
biomedich-729	174	32	and	and	CCONJ
biomedich-729	174	33	toxicity	toxicity	NOUN
biomedich-729	174	34	properties	property	NOUN
biomedich-729	174	35	using	use	VERB
biomedich-729	174	36	insilico	insilico	NOUN
biomedich-729	174	37	techniques	technique	NOUN
biomedich-729	174	38	and	and	CCONJ
biomedich-729	174	39	molecular	molecular	ADJ
biomedich-729	174	40	docking	docking	NOUN
biomedich-729	174	41	.	.	PUNCT
biomedich-729	175	1	the	the	DET
biomedich-729	175	2	binding	binding	NOUN
biomedich-729	175	3	of	of	ADP
biomedich-729	175	4	these	these	DET
biomedich-729	175	5	compounds	compound	NOUN
biomedich-729	175	6	to	to	ADP
biomedich-729	175	7	key	key	ADJ
biomedich-729	175	8	metabolic	metabolic	NOUN
biomedich-729	175	9	proteins	protein	NOUN
biomedich-729	175	10	suggests	suggest	VERB
biomedich-729	175	11	potential	potential	ADJ
biomedich-729	175	12	effects	effect	NOUN
biomedich-729	175	13	on	on	ADP
biomedich-729	175	14	ion	ion	NOUN
biomedich-729	175	15	transport	transport	NOUN
biomedich-729	175	16	and	and	CCONJ
biomedich-729	175	17	liver	liver	NOUN
biomedich-729	175	18	function	function	NOUN
biomedich-729	175	19	.	.	PUNCT
biomedich-729	176	1	however	however	ADV
biomedich-729	176	2	,	,	PUNCT
biomedich-729	176	3	the	the	DET
biomedich-729	176	4	predicted	predict	VERB
biomedich-729	176	5	high	high	ADJ
biomedich-729	176	6	potential	potential	NOUN
biomedich-729	176	7	for	for	ADP
biomedich-729	176	8	adverse	adverse	ADJ
biomedich-729	176	9	reactions	reaction	NOUN
biomedich-729	176	10	,	,	PUNCT
biomedich-729	176	11	including	include	VERB
biomedich-729	176	12	herb	herb	NOUN
biomedich-729	176	13	-	-	PUNCT
biomedich-729	176	14	drug	drug	NOUN
biomedich-729	176	15	interactions	interaction	NOUN
biomedich-729	176	16	and	and	CCONJ
biomedich-729	176	17	mitochondrial	mitochondrial	ADJ
biomedich-729	176	18	toxicity	toxicity	NOUN
biomedich-729	176	19	,	,	PUNCT
biomedich-729	176	20	necessitates	necessitate	VERB
biomedich-729	176	21	further	far	ADV
biomedich-729	176	22	in	in	ADP
biomedich-729	176	23	-	-	PUNCT
biomedich-729	176	24	vitro	vitro	X
biomedich-729	176	25	and	and	CCONJ
biomedich-729	176	26	in	in	ADP
biomedich-729	176	27	-	-	PUNCT
biomedich-729	176	28	vivo	vivo	NOUN
biomedich-729	176	29	studies	study	NOUN
biomedich-729	176	30	to	to	PART
biomedich-729	176	31	validate	validate	VERB
biomedich-729	176	32	these	these	DET
biomedich-729	176	33	findings	finding	NOUN
biomedich-729	176	34	and	and	CCONJ
biomedich-729	176	35	ensure	ensure	VERB
biomedich-729	176	36	the	the	DET
biomedich-729	176	37	safe	safe	ADJ
biomedich-729	176	38	use	use	NOUN
biomedich-729	176	39	of	of	ADP
biomedich-729	176	40	cola	cola	NOUN
biomedich-729	176	41	rostrata	rostrata	NOUN
biomedich-729	176	42	in	in	ADP
biomedich-729	176	43	traditional	traditional	ADJ
biomedich-729	176	44	medicine	medicine	NOUN
biomedich-729	176	45	and	and	CCONJ
biomedich-729	176	46	drug	drug	NOUN
biomedich-729	176	47	formulations	formulation	NOUN
biomedich-729	176	48	.	.	PUNCT
biomedich-729	177	1	authors	author	NOUN
biomedich-729	177	2	’	'	PUNCT
biomedich-729	177	3	contribution	contribution	NOUN
biomedich-729	177	4	:	:	PUNCT
biomedich-729	178	1	abe	abe	ADJ
biomedich-729	178	2	:	:	PUNCT
biomedich-729	178	3	conceptualization	conceptualization	NOUN
biomedich-729	178	4	,	,	PUNCT
biomedich-729	178	5	data	data	NOUN
biomedich-729	178	6	curation	curation	NOUN
biomedich-729	178	7	,	,	PUNCT
biomedich-729	178	8	formal	formal	ADJ
biomedich-729	178	9	analysis	analysis	NOUN
biomedich-729	178	10	,	,	PUNCT
biomedich-729	178	11	methodology	methodology	NOUN
biomedich-729	178	12	,	,	PUNCT
biomedich-729	178	13	validation	validation	NOUN
biomedich-729	178	14	,	,	PUNCT
biomedich-729	178	15	visualization	visualization	NOUN
biomedich-729	178	16	,	,	PUNCT
biomedich-729	178	17	writing	writing	NOUN
biomedich-729	178	18	of	of	ADP
biomedich-729	178	19	original	original	ADJ
biomedich-729	178	20	draft	draft	NOUN
biomedich-729	178	21	,	,	PUNCT
biomedich-729	178	22	review	review	NOUN
biomedich-729	178	23	and	and	CCONJ
biomedich-729	178	24	editing	editing	NOUN
biomedich-729	178	25	of	of	ADP
biomedich-729	178	26	manuscript	manuscript	PROPN
biomedich-729	178	27	aos	aos	PROPN
biomedich-729	178	28	:	:	PUNCT
biomedich-729	178	29	validation	validation	NOUN
biomedich-729	178	30	,	,	PUNCT
biomedich-729	178	31	writing	writing	NOUN
biomedich-729	178	32	of	of	ADP
biomedich-729	178	33	original	original	ADJ
biomedich-729	178	34	draft	draft	NOUN
biomedich-729	178	35	,	,	PUNCT
biomedich-729	178	36	review	review	NOUN
biomedich-729	178	37	and	and	CCONJ
biomedich-729	178	38	editing	editing	NOUN
biomedich-729	178	39	of	of	ADP
biomedich-729	178	40	manuscript	manuscript	NOUN
biomedich-729	178	41	.	.	PUNCT
biomedich-729	179	1	oak	oak	NOUN
biomedich-729	179	2	:	:	PUNCT
biomedich-729	179	3	validation	validation	NOUN
biomedich-729	179	4	,	,	PUNCT
biomedich-729	179	5	review	review	NOUN
biomedich-729	179	6	and	and	CCONJ
biomedich-729	179	7	editing	editing	NOUN
biomedich-729	179	8	of	of	ADP
biomedich-729	179	9	manuscript	manuscript	NOUN
biomedich-729	179	10	.	.	PUNCT
biomedich-729	180	1	mbj	mbj	PROPN
biomedich-729	180	2	:	:	PUNCT
biomedich-729	181	1	validation	validation	NOUN
biomedich-729	181	2	,	,	PUNCT
biomedich-729	181	3	review	review	NOUN
biomedich-729	181	4	and	and	CCONJ
biomedich-729	181	5	editing	editing	NOUN
biomedich-729	181	6	of	of	ADP
biomedich-729	181	7	manuscript	manuscript	NOUN
biomedich-729	181	8	.	.	PUNCT
biomedich-729	182	1	all	all	DET
biomedich-729	182	2	authors	author	NOUN
biomedich-729	182	3	read	read	VERB
biomedich-729	182	4	and	and	CCONJ
biomedich-729	182	5	approved	approve	VERB
biomedich-729	182	6	the	the	DET
biomedich-729	182	7	manuscript	manuscript	NOUN
biomedich-729	182	8	.	.	PUNCT
biomedich-729	183	1	competing	compete	VERB
biomedich-729	183	2	interest	interest	NOUN
biomedich-729	183	3	:	:	PUNCT
biomedich-729	183	4	the	the	DET
biomedich-729	183	5	authors	author	NOUN
biomedich-729	183	6	of	of	ADP
biomedich-729	183	7	the	the	DET
biomedich-729	183	8	article	article	NOUN
biomedich-729	183	9	stated	state	VERB
biomedich-729	183	10	that	that	SCONJ
biomedich-729	183	11	there	there	PRON
biomedich-729	183	12	is	be	VERB
biomedich-729	183	13	no	no	DET
biomedich-729	183	14	competing	compete	VERB
biomedich-729	183	15	interest	interest	NOUN
biomedich-729	183	16	.	.	PUNCT
biomedich-729	184	1	funding	funding	NOUN
biomedich-729	184	2	:	:	PUNCT
biomedich-729	184	3	no	no	DET
biomedich-729	184	4	funding	funding	NOUN
biomedich-729	184	5	was	be	AUX
biomedich-729	184	6	received	receive	VERB
biomedich-729	184	7	to	to	PART
biomedich-729	184	8	prepare	prepare	VERB
biomedich-729	184	9	this	this	DET
biomedich-729	184	10	manuscript	manuscript	NOUN
biomedich-729	184	11	.	.	PUNCT
biomedich-729	185	1	references	reference	NOUN
biomedich-729	185	2	ajayi	ajayi	PROPN
biomedich-729	185	3	,	,	PUNCT
biomedich-729	185	4	b.	b.	PROPN
biomedich-729	185	5	e	e	PROPN
biomedich-729	185	6	,	,	PUNCT
biomedich-729	185	7	oboh	oboh	PROPN
biomedich-729	185	8	,	,	PUNCT
biomedich-729	185	9	b.	b.	PROPN
biomedich-729	185	10	,	,	PUNCT
biomedich-729	185	11	minari	minari	PROPN
biomedich-729	185	12	,	,	PUNCT
biomedich-729	185	13	j.	j.	PROPN
biomedich-729	185	14	b.	b.	PROPN
biomedich-729	185	15	,	,	PUNCT
biomedich-729	185	16	sexton	sexton	PROPN
biomedich-729	185	17	,	,	PUNCT
biomedich-729	185	18	d.	d.	PROPN
biomedich-729	185	19	w.	w.	PROPN
biomedich-729	185	20	,	,	PUNCT
biomedich-729	185	21	sarker	sarker	PROPN
biomedich-729	185	22	,	,	PUNCT
biomedich-729	185	23	s.	s.	PROPN
biomedich-729	185	24	d.	d.	PROPN
biomedich-729	185	25	&	&	CCONJ
biomedich-729	185	26	fatokun	fatokun	PROPN
biomedich-729	185	27	,	,	PUNCT
biomedich-729	185	28	a.	a.	NOUN
biomedich-729	185	29	a.	a.	NOUN
biomedich-729	185	30	(	(	PUNCT
biomedich-729	185	31	2023	2023	NUM
biomedich-729	185	32	)	)	PUNCT
biomedich-729	185	33	cola	cola	NOUN
biomedich-729	185	34	rostrata	rostrata	PROPN
biomedich-729	185	35	k.	k.	PROPN
biomedich-729	185	36	schum	schum	PROPN
biomedich-729	185	37	.	.	PUNCT
biomedich-729	186	1	constituents	constituent	NOUN
biomedich-729	186	2	induce	induce	VERB
biomedich-729	186	3	cytotoxicity	cytotoxicity	NOUN
biomedich-729	186	4	through	through	ADP
biomedich-729	186	5	reactive	reactive	ADJ
biomedich-729	186	6	oxygen	oxygen	NOUN
biomedich-729	186	7	species	species	NOUN
biomedich-729	186	8	generation	generation	NOUN
biomedich-729	186	9	and	and	CCONJ
biomedich-729	186	10	mitochondrial	mitochondrial	ADJ
biomedich-729	186	11	membrane	membrane	NOUN
biomedich-729	186	12	depolarization	depolarization	NOUN
biomedich-729	186	13	.	.	PUNCT
biomedich-729	187	1	exploration	exploration	NOUN
biomedich-729	187	2	of	of	ADP
biomedich-729	187	3	targeted	target	VERB
biomedich-729	187	4	antitumor	antitumor	PROPN
biomedich-729	187	5	therapy	therapy	NOUN
biomedich-729	187	6	,	,	PUNCT
biomedich-729	187	7	4:1328–44	4:1328–44	NOUN
biomedich-729	187	8	.	.	PUNCT
biomedich-729	188	1	https://doi.org/10.37349/etat.2023.00200	https://doi.org/10.37349/etat.2023.00200	PROPN
biomedich-729	188	2	ajayi	ajayi	PROPN
biomedich-729	188	3	,	,	PUNCT
biomedich-729	188	4	b.	b.	PROPN
biomedich-729	188	5	e.	e.	PROPN
biomedich-729	188	6	,	,	PUNCT
biomedich-729	188	7	oboh	oboh	PROPN
biomedich-729	188	8	,	,	PUNCT
biomedich-729	188	9	b.	b.	PROPN
biomedich-729	188	10	,	,	PUNCT
biomedich-729	188	11	minari	minari	PROPN
biomedich-729	188	12	,	,	PUNCT
biomedich-729	188	13	j.	j.	PROPN
biomedich-729	188	14	b.	b.	PROPN
biomedich-729	188	15	&	&	CCONJ
biomedich-729	188	16	fatokun	fatokun	PROPN
biomedich-729	188	17	,	,	PUNCT
biomedich-729	188	18	a.	a.	NOUN
biomedich-729	188	19	a.	a.	NOUN
biomedich-729	188	20	(	(	PUNCT
biomedich-729	188	21	2022	2022	NUM
biomedich-729	188	22	)	)	PUNCT
biomedich-729	188	23	insilico	insilico	NOUN
biomedich-729	188	24	identification	identification	NOUN
biomedich-729	188	25	of	of	ADP
biomedich-729	188	26	protein	protein	NOUN
biomedich-729	188	27	targets	target	NOUN
biomedich-729	188	28	for	for	ADP
biomedich-729	188	29	drug	drug	NOUN
biomedich-729	188	30	-	-	PUNCT
biomedich-729	188	31	like	like	ADJ
biomedich-729	188	32	compounds	compound	NOUN
biomedich-729	188	33	from	from	ADP
biomedich-729	188	34	epicarp	epicarp	ADJ
biomedich-729	188	35	extract	extract	NOUN
biomedich-729	188	36	of	of	ADP
biomedich-729	188	37	cola	cola	PROPN
biomedich-729	188	38	rostrata	rostrata	PROPN
biomedich-729	188	39	k.	k.	PROPN
biomedich-729	188	40	shum	shum	PROPN
biomedich-729	188	41	.	.	PUNCT
biomedich-729	189	1	journal	journal	PROPN
biomedich-729	189	2	of	of	ADP
biomedich-729	189	3	applied	apply	VERB
biomedich-729	189	4	science	science	NOUN
biomedich-729	189	5	and	and	CCONJ
biomedich-729	189	6	environmental	environmental	ADJ
biomedich-729	189	7	management	management	NOUN
biomedich-729	189	8	,	,	PUNCT
biomedich-729	189	9	26(5):903	26(5):903	NOUN
biomedich-729	189	10	-	-	SYM
biomedich-729	189	11	911	911	NUM
biomedich-729	189	12	.	.	PUNCT
biomedich-729	190	1	https://dx.doi.org/10.4314/jasem.v26i5.18	https://dx.doi.org/10.4314/jasem.v26i5.18	PROPN
biomedich-729	190	2	alaei	alaei	PROPN
biomedich-729	190	3	,	,	PUNCT
biomedich-729	190	4	m	m	PROPN
biomedich-729	190	5	,	,	PUNCT
biomedich-729	190	6	nazari	nazari	PROPN
biomedich-729	190	7	,	,	PUNCT
biomedich-729	190	8	se	se	X
biomedich-729	190	9	,	,	PUNCT
biomedich-729	190	10	pourali	pourali	VERB
biomedich-729	190	11	,	,	PUNCT
biomedich-729	190	12	g	g	PROPN
biomedich-729	190	13	,	,	PUNCT
biomedich-729	190	14	asadnia	asadnia	PROPN
biomedich-729	190	15	,	,	PUNCT
biomedich-729	190	16	a	a	PRON
biomedich-729	190	17	,	,	PUNCT
biomedich-729	190	18	moetamani	moetamani	NOUN
biomedich-729	190	19	-	-	PUNCT
biomedich-729	190	20	ahmadi	ahmadi	PROPN
biomedich-729	190	21	,	,	PUNCT
biomedich-729	190	22	m	m	PROPN
biomedich-729	190	23	,	,	PUNCT
biomedich-729	190	24	fiuji	fiuji	ADJ
biomedich-729	190	25	h	h	NOUN
biomedich-729	190	26	,	,	PUNCT
biomedich-729	190	27	et	et	PROPN
biomedich-729	190	28	al	al	PROPN
biomedich-729	190	29	.	.	PROPN
biomedich-729	190	30	(	(	PUNCT
biomedich-729	190	31	2023	2023	NUM
biomedich-729	190	32	)	)	PUNCT
biomedich-729	190	33	therapeutic	therapeutic	ADJ
biomedich-729	190	34	potential	potential	NOUN
biomedich-729	190	35	of	of	ADP
biomedich-729	190	36	targeting	target	VERB
biomedich-729	190	37	the	the	DET
biomedich-729	190	38	cytochrome	cytochrome	NOUN
biomedich-729	190	39	p450	p450	PROPN
biomedich-729	190	40	enzymes	enzyme	NOUN
biomedich-729	190	41	using	use	VERB
biomedich-729	190	42	lopinavir	lopinavir	PROPN
biomedich-729	190	43	/	/	SYM
biomedich-729	190	44	ritonavir	ritonavir	PROPN
biomedich-729	190	45	in	in	ADP
biomedich-729	190	46	colorectal	colorectal	ADJ
biomedich-729	190	47	cancer	cancer	NOUN
biomedich-729	190	48	:	:	PUNCT
biomedich-729	190	49	a	a	DET
biomedich-729	190	50	study	study	NOUN
biomedich-729	190	51	in	in	ADP
biomedich-729	190	52	monolayers	monolayer	NOUN
biomedich-729	190	53	,	,	PUNCT
biomedich-729	190	54	spheroids	spheroid	NOUN
biomedich-729	190	55	and	and	CCONJ
biomedich-729	190	56	in	in	ADP
biomedich-729	190	57	vivo	vivo	NOUN
biomedich-729	190	58	models	model	NOUN
biomedich-729	190	59	.	.	PUNCT
biomedich-729	191	1	cancers	cancer	NOUN
biomedich-729	191	2	,	,	PUNCT
biomedich-729	191	3	15(15):3939	15(15):3939	NUM
biomedich-729	191	4	.	.	PUNCT
biomedich-729	192	1	https://doi.org/10.3390/cancers15153939	https://doi.org/10.3390/cancers15153939	PROPN
biomedich-729	192	2	awodele	awodele	PROPN
biomedich-729	192	3	,	,	PUNCT
biomedich-729	192	4	o.	o.	PROPN
biomedich-729	192	5	,	,	PUNCT
biomedich-729	192	6	fajemirokun	fajemirokun	PROPN
biomedich-729	192	7	,	,	PUNCT
biomedich-729	192	8	o.	o.	PROPN
biomedich-729	192	9	,	,	PUNCT
biomedich-729	192	10	oreagba	oreagba	PROPN
biomedich-729	192	11	,	,	PUNCT
biomedich-729	192	12	i.	i.	PROPN
biomedich-729	192	13	,	,	PUNCT
biomedich-729	192	14	samuel	samuel	PROPN
biomedich-729	192	15	,	,	PUNCT
biomedich-729	192	16	t.	t.	PROPN
biomedich-729	192	17	a.	a.	PROPN
biomedich-729	192	18	,	,	PUNCT
biomedich-729	192	19	popoola	popoola	PROPN
biomedich-729	192	20	,	,	PUNCT
biomedich-729	192	21	t.	t.	PROPN
biomedich-729	192	22	d.	d.	PROPN
biomedich-729	192	23	,	,	PUNCT
biomedich-729	192	24	coulidiaty	coulidiaty	NOUN
biomedich-729	192	25	a.	a.	NOUN
biomedich-729	193	1	v.	v.	ADP
biomedich-729	193	2	et	et	PROPN
biomedich-729	193	3	al	al	PROPN
biomedich-729	193	4	.	.	PROPN
biomedich-729	194	1	(	(	PUNCT
biomedich-729	194	2	2018	2018	NUM
biomedich-729	194	3	)	)	PUNCT
biomedich-729	194	4	herbal	herbal	ADJ
biomedich-729	194	5	medicines	medicine	NOUN
biomedich-729	194	6	use	use	NOUN
biomedich-729	194	7	:	:	PUNCT
biomedich-729	194	8	remedies	remedy	NOUN
biomedich-729	194	9	or	or	CCONJ
biomedich-729	194	10	risks	risk	NOUN
biomedich-729	194	11	.	.	PUNCT
biomedich-729	195	1	west	west	ADJ
biomedich-729	195	2	african	african	PROPN
biomedich-729	195	3	journal	journal	PROPN
biomedich-729	195	4	of	of	ADP
biomedich-729	195	5	pharmacy	pharmacy	NOUN
biomedich-729	195	6	29(2):1	29(2):1	NUM
biomedich-729	195	7	-	-	SYM
biomedich-729	195	8	18	18	NUM
biomedich-729	195	9	.	.	PUNCT
biomedich-729	196	1	başaran	başaran	PROPN
biomedich-729	196	2	,	,	PUNCT
biomedich-729	196	3	n.	n.	NOUN
biomedich-729	196	4	,	,	PUNCT
biomedich-729	196	5	paslı	paslı	PROPN
biomedich-729	196	6	,	,	PUNCT
biomedich-729	196	7	d.	d.	PROPN
biomedich-729	196	8	&	&	CCONJ
biomedich-729	196	9	başaran	başaran	PROPN
biomedich-729	196	10	,	,	PUNCT
biomedich-729	196	11	a.	a.	NOUN
biomedich-729	196	12	a.	a.	NOUN
biomedich-729	196	13	(	(	PUNCT
biomedich-729	196	14	2022	2022	NUM
biomedich-729	196	15	)	)	PUNCT
biomedich-729	196	16	unpredictable	unpredictable	ADJ
biomedich-729	196	17	adverse	adverse	ADJ
biomedich-729	196	18	effects	effect	NOUN
biomedich-729	196	19	of	of	ADP
biomedich-729	196	20	herbal	herbal	ADJ
biomedich-729	196	21	products	product	NOUN
biomedich-729	196	22	.	.	PUNCT
biomedich-729	197	1	food	food	NOUN
biomedich-729	197	2	and	and	CCONJ
biomedich-729	197	3	chemical	chemical	NOUN
biomedich-729	197	4	toxicology	toxicology	NOUN
biomedich-729	197	5	,	,	PUNCT
biomedich-729	197	6	159	159	NUM
biomedich-729	197	7	,	,	PUNCT
biomedich-729	197	8	112762	112762	NUM
biomedich-729	197	9	.	.	PUNCT
biomedich-729	198	1	https://doi.org/10.1016/j.fct.2021.112762	https://doi.org/10.1016/j.fct.2021.112762	PROPN
biomedich-729	198	2	chalasani	chalasani	NOUN
biomedich-729	198	3	,	,	PUNCT
biomedich-729	198	4	n	n	CCONJ
biomedich-729	198	5	,	,	PUNCT
biomedich-729	198	6	bonkovsky	bonkovsky	NOUN
biomedich-729	198	7	,	,	PUNCT
biomedich-729	198	8	h.	h.	PROPN
biomedich-729	198	9	l.	l.	PROPN
biomedich-729	198	10	,	,	PUNCT
biomedich-729	198	11	fontana	fontana	PROPN
biomedich-729	198	12	,	,	PUNCT
biomedich-729	198	13	r.	r.	PROPN
biomedich-729	198	14	,	,	PUNCT
biomedich-729	198	15	lee	lee	PROPN
biomedich-729	198	16	,	,	PUNCT
biomedich-729	198	17	w.	w.	PROPN
biomedich-729	198	18	,	,	PUNCT
biomedich-729	198	19	stolz	stolz	PROPN
biomedich-729	198	20	,	,	PUNCT
biomedich-729	198	21	a.	a.	PROPN
biomedich-729	198	22	,	,	PUNCT
biomedich-729	198	23	talwalkar	talwalkar	PROPN
biomedich-729	198	24	,	,	PUNCT
biomedich-729	198	25	j.	j.	PROPN
biomedich-729	198	26	et	et	PROPN
biomedich-729	198	27	al	al	PROPN
biomedich-729	198	28	.	.	PROPN
biomedich-729	199	1	(	(	PUNCT
biomedich-729	199	2	2015	2015	NUM
biomedich-729	199	3	)	)	PUNCT
biomedich-729	199	4	united	united	PROPN
biomedich-729	199	5	states	states	PROPN
biomedich-729	199	6	drug	drug	PROPN
biomedich-729	199	7	induced	induce	VERB
biomedich-729	199	8	liver	liver	NOUN
biomedich-729	199	9	injury	injury	NOUN
biomedich-729	199	10	network	network	NOUN
biomedich-729	199	11	.	.	PUNCT
biomedich-729	200	1	features	feature	NOUN
biomedich-729	200	2	and	and	CCONJ
biomedich-729	200	3	outcomes	outcome	NOUN
biomedich-729	200	4	of	of	ADP
biomedich-729	200	5	899	899	NUM
biomedich-729	200	6	patients	patient	NOUN
biomedich-729	200	7	with	with	ADP
biomedich-729	200	8	drug	drug	NOUN
biomedich-729	200	9	-	-	PUNCT
biomedich-729	200	10	induced	induce	VERB
biomedich-729	200	11	liver	liver	NOUN
biomedich-729	200	12	injury	injury	NOUN
biomedich-729	200	13	:	:	PUNCT
biomedich-729	200	14	the	the	DET
biomedich-729	200	15	dilin	dilin	PROPN
biomedich-729	200	16	prospective	prospective	ADJ
biomedich-729	200	17	study	study	NOUN
biomedich-729	200	18	.	.	PUNCT
biomedich-729	201	1	gastroenterology	gastroenterology	NOUN
biomedich-729	201	2	,	,	PUNCT
biomedich-729	201	3	148(7):1340	148(7):1340	NUM
biomedich-729	201	4	-	-	SYM
biomedich-729	201	5	52.e7	52.e7	NUM
biomedich-729	201	6	.	.	PUNCT
biomedich-729	202	1	https://doi.org/10.1053/j.gastro.2015.03.006	https://doi.org/10.1053/j.gastro.2015.03.006	NOUN
biomedich-729	202	2	dongmo	dongmo	ADJ
biomedich-729	202	3	,	,	PUNCT
biomedich-729	202	4	t.	t.	PROPN
biomedich-729	202	5	t.	t.	PROPN
biomedich-729	202	6	w.	w.	PROPN
biomedich-729	202	7	,	,	PUNCT
biomedich-729	202	8	azebaze	azebaze	VERB
biomedich-729	202	9	,	,	PUNCT
biomedich-729	202	10	a.	a.	NOUN
biomedich-729	202	11	,	,	PUNCT
biomedich-729	202	12	mbosso	mbosso	NOUN
biomedich-729	202	13	,	,	PUNCT
biomedich-729	202	14	e.	e.	PROPN
biomedich-729	202	15	,	,	PUNCT
biomedich-729	202	16	lenta	lenta	PROPN
biomedich-729	202	17	,	,	PUNCT
biomedich-729	202	18	b.	b.	PROPN
biomedich-729	202	19	,	,	PUNCT
biomedich-729	202	20	bosyom	bosyom	PROPN
biomedich-729	202	21	,	,	PUNCT
biomedich-729	202	22	f.	f.	PROPN
biomedich-729	202	23	,	,	PUNCT
biomedich-729	202	24	tchaleu	tchaleu	PROPN
biomedich-729	202	25	b.	b.	PROPN
biomedich-729	202	26	et	et	PROPN
biomedich-729	202	27	al	al	PROPN
biomedich-729	202	28	.	.	PROPN
biomedich-729	203	1	(	(	PUNCT
biomedich-729	203	2	2019	2019	NUM
biomedich-729	203	3	)	)	PUNCT
biomedich-729	203	4	new	new	ADJ
biomedich-729	203	5	unsaturated	unsaturate	VERB
biomedich-729	203	6	fatty	fatty	NOUN
biomedich-729	203	7	acid	acid	NOUN
biomedich-729	203	8	and	and	CCONJ
biomedich-729	203	9	other	other	ADJ
biomedich-729	203	10	chemical	chemical	ADJ
biomedich-729	203	11	constituents	constituent	NOUN
biomedich-729	203	12	from	from	ADP
biomedich-729	203	13	the	the	DET
biomedich-729	203	14	roots	root	NOUN
biomedich-729	203	15	of	of	ADP
biomedich-729	203	16	cola	cola	PROPN
biomedich-729	203	17	rostrata	rostrata	PROPN
biomedich-729	203	18	k.	k.	PROPN
biomedich-729	203	19	schum	schum	PROPN
biomedich-729	203	20	.	.	PUNCT
biomedich-729	204	1	(	(	PUNCT
biomedich-729	204	2	malvaceae	malvaceae	PROPN
biomedich-729	204	3	)	)	PUNCT
biomedich-729	204	4	.	.	PUNCT
biomedich-729	205	1	biochemical	biochemical	ADJ
biomedich-729	205	2	systematics	systematic	NOUN
biomedich-729	205	3	and	and	CCONJ
biomedich-729	205	4	ecology	ecology	NOUN
biomedich-729	205	5	,	,	PUNCT
biomedich-729	205	6	86:103913	86:103913	PROPN
biomedich-729	205	7	.	.	PUNCT
biomedich-729	206	1	http://dx.doi.org/10.1016/j.bse.2019.103913	http://dx.doi.org/10.1016/j.bse.2019.103913	PROPN
biomedich-729	206	2	eissa	eissa	ADJ
biomedich-729	206	3	,	,	PUNCT
biomedich-729	206	4	l.	l.	PROPN
biomedich-729	206	5	a.	a.	PROPN
biomedich-729	206	6	,	,	PUNCT
biomedich-729	206	7	elsherbiny	elsherbiny	PROPN
biomedich-729	206	8	,	,	PUNCT
biomedich-729	206	9	n.	n.	PROPN
biomedich-729	206	10	m.	m.	PROPN
biomedich-729	206	11	&	&	CCONJ
biomedich-729	206	12	maghmomeh	maghmomeh	PROPN
biomedich-729	206	13	,	,	PUNCT
biomedich-729	206	14	a.	a.	NOUN
biomedich-729	206	15	o.	o.	PROPN
biomedich-729	206	16	(	(	PUNCT
biomedich-729	206	17	2017	2017	NUM
biomedich-729	206	18	)	)	PUNCT
biomedich-729	206	19	effect	effect	NOUN
biomedich-729	206	20	of	of	ADP
biomedich-729	206	21	2	2	NUM
biomedich-729	206	22	-	-	NOUN
biomedich-729	206	23	hydroxychalcone	hydroxychalcone	NOUN
biomedich-729	206	24	on	on	ADP
biomedich-729	206	25	adiponectin	adiponectin	NOUN
biomedich-729	206	26	level	level	NOUN
biomedich-729	206	27	in	in	ADP
biomedich-729	206	28	type	type	NOUN
biomedich-729	206	29	2	2	NUM
biomedich-729	206	30	diabetes	diabetes	NOUN
biomedich-729	206	31	induced	induce	VERB
biomedich-729	206	32	experimentally	experimentally	ADV
biomedich-729	206	33	in	in	ADP
biomedich-729	206	34	rats	rat	NOUN
biomedich-729	206	35	.	.	PUNCT
biomedich-729	207	1	egyptian	egyptian	ADJ
biomedich-729	207	2	journal	journal	PROPN
biomedich-729	207	3	of	of	ADP
biomedich-729	207	4	basic	basic	ADJ
biomedich-729	207	5	and	and	CCONJ
biomedich-729	207	6	applied	applied	ADJ
biomedich-729	207	7	sciences	science	NOUN
biomedich-729	207	8	,	,	PUNCT
biomedich-729	207	9	4	4	NUM
biomedich-729	207	10	,	,	PUNCT
biomedich-729	207	11	1	1	NUM
biomedich-729	207	12	-	-	SYM
biomedich-729	207	13	8	8	NUM
biomedich-729	207	14	.	.	PUNCT
biomedich-729	208	1	http://dx.doi.org/10.1016/j.ejbas.2016.12.002	http://dx.doi.org/10.1016/j.ejbas.2016.12.002	NOUN
biomedich-729	208	2	ekalu	ekalu	ADJ
biomedich-729	208	3	,	,	PUNCT
biomedich-729	208	4	a.	a.	NOUN
biomedich-729	208	5	&	&	CCONJ
biomedich-729	208	6	habila	habila	PROPN
biomedich-729	208	7	,	,	PUNCT
biomedich-729	208	8	j.	j.	PROPN
biomedich-729	208	9	d.	d.	PROPN
biomedich-729	208	10	(	(	PUNCT
biomedich-729	208	11	2020	2020	NUM
biomedich-729	208	12	)	)	PUNCT
biomedich-729	208	13	phytochemistry	phytochemistry	NOUN
biomedich-729	208	14	,	,	PUNCT
biomedich-729	208	15	pharmacology	pharmacology	NOUN
biomedich-729	208	16	and	and	CCONJ
biomedich-729	208	17	medicinal	medicinal	ADJ
biomedich-729	208	18	uses	use	NOUN
biomedich-729	208	19	of	of	ADP
biomedich-729	208	20	cola	cola	PROPN
biomedich-729	208	21	(	(	PUNCT
biomedich-729	208	22	malvaceae	malvaceae	PROPN
biomedich-729	208	23	)	)	PUNCT
biomedich-729	208	24	family	family	NOUN
biomedich-729	208	25	:	:	PUNCT
biomedich-729	208	26	a	a	DET
biomedich-729	208	27	review	review	NOUN
biomedich-729	208	28	.	.	PUNCT
biomedich-729	209	1	medicinal	medicinal	ADJ
biomedich-729	209	2	chemistry	chemistry	NOUN
biomedich-729	209	3	research	research	NOUN
biomedich-729	209	4	,	,	PUNCT
biomedich-729	209	5	29	29	NUM
biomedich-729	209	6	,	,	PUNCT
biomedich-729	209	7	2089–2105	2089–2105	NOUN
biomedich-729	209	8	.	.	PUNCT
biomedich-729	210	1	https://link.springer.com/article/10.1007/s00044-020-02637-x	https://link.springer.com/article/10.1007/s00044-020-02637-x	PROPN
biomedich-729	210	2	ekor	ekor	PROPN
biomedich-729	210	3	,	,	PUNCT
biomedich-729	210	4	m.	m.	NOUN
biomedich-729	210	5	(	(	PUNCT
biomedich-729	210	6	2014	2014	NUM
biomedich-729	210	7	)	)	PUNCT
biomedich-729	210	8	.	.	PUNCT
biomedich-729	211	1	the	the	DET
biomedich-729	211	2	growing	grow	VERB
biomedich-729	211	3	use	use	NOUN
biomedich-729	211	4	of	of	ADP
biomedich-729	211	5	herbal	herbal	ADJ
biomedich-729	211	6	medicines	medicine	NOUN
biomedich-729	211	7	:	:	PUNCT
biomedich-729	211	8	issues	issue	NOUN
biomedich-729	211	9	relating	relate	VERB
biomedich-729	211	10	to	to	ADP
biomedich-729	211	11	adverse	adverse	ADJ
biomedich-729	211	12	reactions	reaction	NOUN
biomedich-729	211	13	and	and	CCONJ
biomedich-729	211	14	challenges	challenge	NOUN
biomedich-729	211	15	in	in	ADP
biomedich-729	211	16	monitoring	monitor	VERB
biomedich-729	211	17	safety	safety	NOUN
biomedich-729	211	18	.	.	PUNCT
biomedich-729	212	1	frontiers	frontier	NOUN
biomedich-729	212	2	in	in	ADP
biomedich-729	212	3	pharmacology	pharmacology	NOUN
biomedich-729	212	4	,	,	PUNCT
biomedich-729	212	5	4:177	4:177	NUM
biomedich-729	212	6	.	.	PUNCT
biomedich-729	213	1	https://doi.org/10.3389/fphar.2013.00177	https://doi.org/10.3389/fphar.2013.00177	PROPN
biomedich-729	213	2	frenzel	frenzel	PROPN
biomedich-729	213	3	,	,	PUNCT
biomedich-729	213	4	c.	c.	PROPN
biomedich-729	213	5	&	&	CCONJ
biomedich-729	213	6	teschke	teschke	PROPN
biomedich-729	213	7	,	,	PUNCT
biomedich-729	213	8	r.	r.	PROPN
biomedich-729	213	9	(	(	PUNCT
biomedich-729	213	10	2016	2016	NUM
biomedich-729	213	11	)	)	PUNCT
biomedich-729	213	12	herbal	herbal	ADJ
biomedich-729	213	13	hepatotoxicity	hepatotoxicity	NOUN
biomedich-729	213	14	:	:	PUNCT
biomedich-729	213	15	clinical	clinical	ADJ
biomedich-729	213	16	characteristics	characteristic	NOUN
biomedich-729	213	17	and	and	CCONJ
biomedich-729	213	18	listing	list	VERB
biomedich-729	213	19	compilation	compilation	NOUN
biomedich-729	213	20	.	.	PUNCT
biomedich-729	214	1	international	international	ADJ
biomedich-729	214	2	journal	journal	NOUN
biomedich-729	214	3	of	of	ADP
biomedich-729	214	4	molecular	molecular	ADJ
biomedich-729	214	5	sciences	science	NOUN
biomedich-729	214	6	,	,	PUNCT
biomedich-729	214	7	17(5):588	17(5):588	NUM
biomedich-729	214	8	.	.	PUNCT
biomedich-729	215	1	https://doi.org/10.3390/ijms17050588	https://doi.org/10.3390/ijms17050588	PROPN
biomedich-729	215	2	guengerich	guengerich	PROPN
biomedich-729	215	3	,	,	PUNCT
biomedich-729	215	4	f.	f.	PROPN
biomedich-729	215	5	p.	p.	PROPN
biomedich-729	215	6	(	(	PUNCT
biomedich-729	215	7	2022	2022	NUM
biomedich-729	215	8	)	)	PUNCT
biomedich-729	215	9	inhibition	inhibition	NOUN
biomedich-729	215	10	of	of	ADP
biomedich-729	215	11	cytochrome	cytochrome	ADJ
biomedich-729	215	12	p450	p450	NUM
biomedich-729	215	13	enzymes	enzyme	NOUN
biomedich-729	215	14	by	by	ADP
biomedich-729	215	15	drugs	drug	NOUN
biomedich-729	215	16	-	-	PUNCT
biomedich-729	215	17	molecular	molecular	ADJ
biomedich-729	215	18	basis	basis	NOUN
biomedich-729	215	19	and	and	CCONJ
biomedich-729	215	20	practical	practical	ADJ
biomedich-729	215	21	applications	application	NOUN
biomedich-729	215	22	.	.	PUNCT
biomedich-729	216	1	biomolecules	biomolecule	NOUN
biomedich-729	216	2	&	&	CCONJ
biomedich-729	216	3	therapeutics	therapeutic	NOUN
biomedich-729	216	4	,	,	PUNCT
biomedich-729	216	5	30:1	30:1	NUM
biomedich-729	216	6	-	-	SYM
biomedich-729	216	7	18	18	NUM
biomedich-729	216	8	.	.	PUNCT
biomedich-729	217	1	https://doi.org/10.4062/biomolther.2021.102	https://doi.org/10.4062/biomolther.2021.102	PRON
biomedich-729	217	2	herrmann	herrmann	PROPN
biomedich-729	217	3	,	,	PUNCT
biomedich-729	217	4	j.	j.	PROPN
biomedich-729	217	5	m.	m.	PROPN
biomedich-729	217	6	&	&	CCONJ
biomedich-729	217	7	riemer	riemer	PROPN
biomedich-729	217	8	,	,	PUNCT
biomedich-729	217	9	j.	j.	PROPN
biomedich-729	217	10	(	(	PUNCT
biomedich-729	217	11	2021	2021	NUM
biomedich-729	217	12	)	)	PUNCT
biomedich-729	217	13	apoptosis	apoptosis	NOUN
biomedich-729	217	14	inducing	induce	VERB
biomedich-729	217	15	factor	factor	NOUN
biomedich-729	217	16	and	and	CCONJ
biomedich-729	217	17	mitochondrial	mitochondrial	ADJ
biomedich-729	217	18	nadh	nadh	NOUN
biomedich-729	217	19	dehydrogenases	dehydrogenase	NOUN
biomedich-729	217	20	:	:	PUNCT
biomedich-729	217	21	redox	redox	NOUN
biomedich-729	217	22	-	-	PUNCT
biomedich-729	217	23	controlled	control	VERB
biomedich-729	217	24	gear	gear	NOUN
biomedich-729	217	25	boxes	box	NOUN
biomedich-729	217	26	to	to	PART
biomedich-729	217	27	switch	switch	VERB
biomedich-729	217	28	between	between	ADP
biomedich-729	217	29	mitochondrial	mitochondrial	ADJ
biomedich-729	217	30	biogenesis	biogenesis	NOUN
biomedich-729	217	31	and	and	CCONJ
biomedich-729	217	32	cell	cell	NOUN
biomedich-729	217	33	death	death	NOUN
biomedich-729	217	34	.	.	PUNCT
biomedich-729	218	1	biological	biological	ADJ
biomedich-729	218	2	chemistry	chemistry	NOUN
biomedich-729	218	3	,	,	PUNCT
biomedich-729	218	4	402(3):289	402(3):289	NUM
biomedich-729	218	5	-	-	PUNCT
biomedich-729	218	6	297	297	NUM
biomedich-729	218	7	.	.	PUNCT
biomedich-729	219	1	https://doi.org/10.1515/hsz-2020-0254	https://doi.org/10.1515/hsz-2020-0254	PROPN
biomedich-729	219	2	kariuki	kariuki	PROPN
biomedich-729	219	3	,	,	PUNCT
biomedich-729	219	4	d.k	d.k	PROPN
biomedich-729	219	5	.	.	PROPN
biomedich-729	219	6	,	,	PUNCT
biomedich-729	219	7	kanui	kanui	PROPN
biomedich-729	219	8	,	,	PUNCT
biomedich-729	219	9	t.i	t.i	PROPN
biomedich-729	219	10	.	.	PROPN
biomedich-729	219	11	,	,	PUNCT
biomedich-729	219	12	mbugua	mbugua	PROPN
biomedich-729	219	13	,	,	PUNCT
biomedich-729	219	14	p.m.	p.m.	PROPN
biomedich-729	219	15	&	&	CCONJ
biomedich-729	219	16	githinji	githinji	PROPN
biomedich-729	219	17	,	,	PUNCT
biomedich-729	219	18	c.g	c.g	PROPN
biomedich-729	219	19	.	.	PROPN
biomedich-729	219	20	(	(	PUNCT
biomedich-729	219	21	2012	2012	NUM
biomedich-729	219	22	)	)	PUNCT
biomedich-729	219	23	analgesic	analgesic	ADJ
biomedich-729	219	24	and	and	CCONJ
biomedich-729	219	25	anti	anti	ADJ
biomedich-729	219	26	-	-	ADJ
biomedich-729	219	27	inflammatory	inflammatory	ADJ
biomedich-729	219	28	activities	activity	NOUN
biomedich-729	219	29	of	of	ADP
biomedich-729	219	30	9	9	NUM
biomedich-729	219	31	-	-	PUNCT
biomedich-729	219	32	hexacosene	hexacosene	NOUN
biomedich-729	219	33	and	and	CCONJ
biomedich-729	219	34	stigmasterol	stigmasterol	NOUN
biomedich-729	219	35	isolated	isolate	VERB
biomedich-729	219	36	from	from	ADP
biomedich-729	219	37	mondia	mondia	NOUN
biomedich-729	219	38	whytei	whytei	NOUN
biomedich-729	219	39	.	.	PUNCT
biomedich-729	220	1	phytopharmacology	phytopharmacology	NOUN
biomedich-729	220	2	2:212–223	2:212–223	PROPN
biomedich-729	220	3	.	.	PUNCT
biomedich-729	221	1	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/2	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/2	PROPN
biomedich-729	221	2	8485	8485	NUM
biomedich-729	221	3	ajayi	ajayi	NOUN
biomedich-729	221	4	et	et	PROPN
biomedich-729	221	5	al	al	PROPN
biomedich-729	221	6	.	.	PROPN
biomedich-729	221	7	–	–	PUNCT
biomedich-729	221	8	toxicity	toxicity	NOUN
biomedich-729	221	9	prediction	prediction	NOUN
biomedich-729	221	10	of	of	ADP
biomedich-729	221	11	cola	cola	PROPN
biomedich-729	221	12	rostrata	rostrata	PROPN
biomedich-729	221	13	epicarp	epicarp	PROPN
biomedich-729	221	14	379	379	NUM
biomedich-729	221	15	koc	koc	PROPN
biomedich-729	221	16	.	.	PUNCT
biomedich-729	222	1	k.	k.	PROPN
biomedich-729	222	2	,	,	PUNCT
biomedich-729	222	3	geyikoglu	geyikoglu	PROPN
biomedich-729	222	4	.	.	PUNCT
biomedich-729	223	1	f.	f.	PROPN
biomedich-729	223	2	,	,	PUNCT
biomedich-729	223	3	cakmak	cakmak	PROPN
biomedich-729	223	4	.	.	PUNCT
biomedich-729	224	1	o.	o.	PROPN
biomedich-729	224	2	,	,	PUNCT
biomedich-729	224	3	koca	koca	PROPN
biomedich-729	224	4	,	,	PUNCT
biomedich-729	224	5	a.	a.	PROPN
biomedich-729	224	6	,	,	PUNCT
biomedich-729	224	7	kutlu	kutlu	PROPN
biomedich-729	224	8	,	,	PUNCT
biomedich-729	224	9	z.	z.	PROPN
biomedich-729	224	10	,	,	PUNCT
biomedich-729	224	11	aysin	aysin	PROPN
biomedich-729	224	12	,	,	PUNCT
biomedich-729	224	13	f.	f.	PROPN
biomedich-729	224	14	et	et	PROPN
biomedich-729	224	15	al	al	PROPN
biomedich-729	224	16	.	.	PROPN
biomedich-729	224	17	(	(	PUNCT
biomedich-729	224	18	2021	2021	NUM
biomedich-729	224	19	)	)	PUNCT
biomedich-729	224	20	the	the	DET
biomedich-729	224	21	targets	target	NOUN
biomedich-729	224	22	of	of	ADP
biomedich-729	224	23	β	β	NOUN
biomedich-729	224	24	-	-	NOUN
biomedich-729	224	25	sitosterol	sitosterol	NOUN
biomedich-729	224	26	as	as	ADP
biomedich-729	224	27	a	a	DET
biomedich-729	224	28	novel	novel	NOUN
biomedich-729	224	29	therapeutic	therapeutic	ADJ
biomedich-729	224	30	against	against	ADP
biomedich-729	224	31	cardio	cardio	NOUN
biomedich-729	224	32	-	-	PUNCT
biomedich-729	224	33	renal	renal	ADJ
biomedich-729	224	34	complications	complication	NOUN
biomedich-729	224	35	in	in	ADP
biomedich-729	224	36	acute	acute	ADJ
biomedich-729	224	37	renal	renal	ADJ
biomedich-729	224	38	ischemia/	ischemia/	NUM
biomedich-729	224	39	reperfusion	reperfusion	NOUN
biomedich-729	224	40	damage	damage	NOUN
biomedich-729	224	41	.	.	PUNCT
biomedich-729	225	1	naunyn	naunyn	PROPN
biomedich-729	225	2	-	-	PUNCT
biomedich-729	225	3	schmiedeberg	schmiedeberg	PROPN
biomedich-729	225	4	's	's	PART
biomedich-729	225	5	archives	archive	NOUN
biomedich-729	225	6	of	of	ADP
biomedich-729	225	7	pharmacology	pharmacology	NOUN
biomedich-729	225	8	,	,	PUNCT
biomedich-729	225	9	394	394	NUM
biomedich-729	225	10	,	,	PUNCT
biomedich-729	225	11	469–479	469–479	NUM
biomedich-729	225	12	.	.	PUNCT
biomedich-729	226	1	https://doi.org/10.1007/s00210020-01984-1	https://doi.org/10.1007/s00210020-01984-1	PROPN
biomedich-729	226	2	matotoka	matotoka	VERB
biomedich-729	226	3	,	,	PUNCT
biomedich-729	226	4	m.	m.	NOUN
biomedich-729	226	5	m.	m.	PROPN
biomedich-729	226	6	&	&	CCONJ
biomedich-729	226	7	masoko	masoko	PROPN
biomedich-729	226	8	,	,	PUNCT
biomedich-729	226	9	p.	p.	NOUN
biomedich-729	226	10	(	(	PUNCT
biomedich-729	226	11	2018	2018	NUM
biomedich-729	226	12	)	)	PUNCT
biomedich-729	226	13	.	.	PUNCT
biomedich-729	227	1	phytochemical	phytochemical	ADJ
biomedich-729	227	2	analysis	analysis	NOUN
biomedich-729	227	3	,	,	PUNCT
biomedich-729	227	4	antioxidant	antioxidant	ADJ
biomedich-729	227	5	,	,	PUNCT
biomedich-729	227	6	antibacterial	antibacterial	ADJ
biomedich-729	227	7	and	and	CCONJ
biomedich-729	227	8	combinational	combinational	ADJ
biomedich-729	227	9	effects	effect	NOUN
biomedich-729	227	10	of	of	ADP
biomedich-729	227	11	medicinal	medicinal	ADJ
biomedich-729	227	12	plants	plant	NOUN
biomedich-729	227	13	used	use	VERB
biomedich-729	227	14	by	by	ADP
biomedich-729	227	15	bapedi	bapedi	ADJ
biomedich-729	227	16	traditional	traditional	ADJ
biomedich-729	227	17	healers	healer	NOUN
biomedich-729	227	18	to	to	PART
biomedich-729	227	19	prepare	prepare	VERB
biomedich-729	227	20	herbal	herbal	ADJ
biomedich-729	227	21	mixtures	mixture	NOUN
biomedich-729	227	22	.	.	PUNCT
biomedich-729	228	1	journal	journal	NOUN
biomedich-729	228	2	of	of	ADP
biomedich-729	228	3	medicinal	medicinal	ADJ
biomedich-729	228	4	plants	plant	NOUN
biomedich-729	228	5	research	research	NOUN
biomedich-729	228	6	.	.	PUNCT
biomedich-729	229	1	12	12	NUM
biomedich-729	229	2	.	.	X
biomedich-729	230	1	563	563	NUM
biomedich-729	230	2	-	-	SYM
biomedich-729	230	3	574	574	NUM
biomedich-729	230	4	.	.	PUNCT
biomedich-729	231	1	http://dx.doi.org/10.5897/jmpr2018.6688	http://dx.doi.org/10.5897/jmpr2018.6688	PROPN
biomedich-729	231	2	mejıa	mejıa	PROPN
biomedich-729	231	3	,	,	PUNCT
biomedich-729	231	4	g.	g.	PROPN
biomedich-729	231	5	,	,	PUNCT
biomedich-729	231	6	saiz	saiz	PROPN
biomedich-729	231	7	-	-	PUNCT
biomedich-729	231	8	rodrı´guez	rodrı´guez	NOUN
biomedich-729	231	9	,	,	PUNCT
biomedich-729	231	10	m.	m.	NOUN
biomedich-729	231	11	,	,	PUNCT
biomedich-729	231	12	go´mez	go´mez	X
biomedich-729	231	13	de	de	X
biomedich-729	231	14	olea	olea	PROPN
biomedich-729	231	15	.	.	PUNCT
biomedich-729	232	1	b.	b.	PROPN
biomedich-729	232	2	,	,	PUNCT
biomedich-729	232	3	ochoa	ochoa	PROPN
biomedich-729	232	4	,	,	PUNCT
biomedich-729	232	5	d.	d.	PROPN
biomedich-729	232	6	&	&	CCONJ
biomedich-729	232	7	abad	abad	PROPN
biomedich-729	232	8	-	-	PUNCT
biomedich-729	232	9	santos	santos	PROPN
biomedich-729	232	10	,	,	PUNCT
biomedich-729	232	11	f.	f.	PROPN
biomedich-729	232	12	(	(	PUNCT
biomedich-729	232	13	2020	2020	NUM
biomedich-729	232	14	)	)	PUNCT
biomedich-729	232	15	urgent	urgent	ADJ
biomedich-729	232	16	hospitaladmissions	hospitaladmission	NOUN
biomedich-729	232	17	caused	cause	VERB
biomedich-729	232	18	by	by	ADP
biomedich-729	232	19	adverse	adverse	ADJ
biomedich-729	232	20	drug	drug	NOUN
biomedich-729	232	21	reactions	reaction	NOUN
biomedich-729	232	22	and	and	CCONJ
biomedich-729	232	23	medication	medication	NOUN
biomedich-729	232	24	errors	error	NOUN
biomedich-729	232	25	—	—	PUNCT
biomedich-729	232	26	apopulation	apopulation	NOUN
biomedich-729	232	27	-	-	PUNCT
biomedich-729	232	28	based	base	VERB
biomedich-729	232	29	study	study	NOUN
biomedich-729	232	30	in	in	ADP
biomedich-729	232	31	spain	spain	PROPN
biomedich-729	232	32	.	.	PUNCT
biomedich-729	233	1	frontiers	frontier	NOUN
biomedich-729	233	2	in	in	ADP
biomedich-729	233	3	pharmacology	pharmacology	NOUN
biomedich-729	233	4	,	,	PUNCT
biomedich-729	233	5	11:734	11:734	NUM
biomedich-729	233	6	.	.	PUNCT
biomedich-729	234	1	https://doi.org/10.3389/fphar.2020.00734	https://doi.org/10.3389/fphar.2020.00734	PROPN
biomedich-729	234	2	mintah	mintah	PROPN
biomedich-729	234	3	,	,	PUNCT
biomedich-729	234	4	s.	s.	PROPN
biomedich-729	234	5	,	,	PUNCT
biomedich-729	234	6	archer	archer	PROPN
biomedich-729	234	7	,	,	PUNCT
biomedich-729	234	8	m.	m.	NOUN
biomedich-729	234	9	,	,	PUNCT
biomedich-729	234	10	asafo	asafo	NOUN
biomedich-729	234	11	-	-	PUNCT
biomedich-729	234	12	agyei	agyei	NOUN
biomedich-729	234	13	,	,	PUNCT
biomedich-729	234	14	t.	t.	PROPN
biomedich-729	234	15	,	,	PUNCT
biomedich-729	234	16	ayertey	ayertey	PROPN
biomedich-729	234	17	,	,	PUNCT
biomedich-729	234	18	f.	f.	PROPN
biomedich-729	234	19	,	,	PUNCT
biomedich-729	234	20	jnr	jnr	PROPN
biomedich-729	234	21	,	,	PUNCT
biomedich-729	234	22	p.	p.	NOUN
biomedich-729	234	23	,	,	PUNCT
biomedich-729	234	24	boamah	boamah	PROPN
biomedich-729	234	25	,	,	PUNCT
biomedich-729	234	26	d.	d.	PROPN
biomedich-729	234	27	&	&	CCONJ
biomedich-729	234	28	barimah	barimah	PROPN
biomedich-729	234	29	,	,	PUNCT
biomedich-729	234	30	k.	k.	PROPN
biomedich-729	234	31	(	(	PUNCT
biomedich-729	234	32	2022	2022	NUM
biomedich-729	234	33	)	)	PUNCT
biomedich-729	234	34	medicinal	medicinal	ADJ
biomedich-729	234	35	plant	plant	NOUN
biomedich-729	234	36	use	use	NOUN
biomedich-729	234	37	in	in	ADP
biomedich-729	234	38	ghana	ghana	PROPN
biomedich-729	234	39	:	:	PUNCT
biomedich-729	234	40	advancement	advancement	NOUN
biomedich-729	234	41	and	and	CCONJ
biomedich-729	234	42	challenges	challenge	NOUN
biomedich-729	234	43	.	.	PUNCT
biomedich-729	235	1	american	american	ADJ
biomedich-729	235	2	journal	journal	PROPN
biomedich-729	235	3	of	of	ADP
biomedich-729	235	4	plant	plant	NOUN
biomedich-729	235	5	sciences	science	NOUN
biomedich-729	235	6	,	,	PUNCT
biomedich-729	235	7	13	13	NUM
biomedich-729	235	8	,	,	PUNCT
biomedich-729	235	9	316	316	NUM
biomedich-729	235	10	-	-	SYM
biomedich-729	235	11	358	358	NUM
biomedich-729	235	12	.	.	PUNCT
biomedich-729	236	1	https://doi.org/10.4236/ajps.2022.133020	https://doi.org/10.4236/ajps.2022.133020	PROPN
biomedich-729	236	2	murali	murali	PROPN
biomedich-729	236	3	,	,	PUNCT
biomedich-729	236	4	m.	m.	NOUN
biomedich-729	236	5	&	&	CCONJ
biomedich-729	236	6	shivanandappa	shivanandappa	PROPN
biomedich-729	236	7	,	,	PUNCT
biomedich-729	236	8	t.	t.	PROPN
biomedich-729	236	9	(	(	PUNCT
biomedich-729	236	10	2022	2022	NUM
biomedich-729	236	11	)	)	PUNCT
biomedich-729	236	12	endosulfan	endosulfan	NOUN
biomedich-729	236	13	causes	cause	VERB
biomedich-729	236	14	oxidative	oxidative	ADJ
biomedich-729	236	15	stress	stress	NOUN
biomedich-729	236	16	in	in	ADP
biomedich-729	236	17	the	the	DET
biomedich-729	236	18	liver	liver	NOUN
biomedich-729	236	19	and	and	CCONJ
biomedich-729	236	20	brain	brain	NOUN
biomedich-729	236	21	that	that	PRON
biomedich-729	236	22	involves	involve	VERB
biomedich-729	236	23	inhibition	inhibition	NOUN
biomedich-729	236	24	of	of	ADP
biomedich-729	236	25	nadh	nadh	NOUN
biomedich-729	236	26	dehydrogenase	dehydrogenase	NOUN
biomedich-729	236	27	and	and	CCONJ
biomedich-729	236	28	altered	alter	VERB
biomedich-729	236	29	antioxidant	antioxidant	ADJ
biomedich-729	236	30	enzyme	enzyme	NOUN
biomedich-729	236	31	status	status	NOUN
biomedich-729	236	32	in	in	ADP
biomedich-729	236	33	rat	rat	PROPN
biomedich-729	236	34	.	.	PROPN
biomedich-729	236	35	ecotoxicology	ecotoxicology	PROPN
biomedich-729	236	36	and	and	CCONJ
biomedich-729	236	37	environmental	environmental	ADJ
biomedich-729	236	38	safety	safety	NOUN
biomedich-729	236	39	,	,	PUNCT
biomedich-729	236	40	239	239	NUM
biomedich-729	236	41	,	,	PUNCT
biomedich-729	236	42	113593	113593	NUM
biomedich-729	236	43	.	.	PUNCT
biomedich-729	237	1	https://doi.org/10.1016/j.ecoenv.2022.113593	https://doi.org/10.1016/j.ecoenv.2022.113593	PROPN
biomedich-729	237	2	newman	newman	PROPN
biomedich-729	237	3	,	,	PUNCT
biomedich-729	237	4	d.	d.	PROPN
biomedich-729	237	5	j.	j.	PROPN
biomedich-729	237	6	&	&	CCONJ
biomedich-729	237	7	cragg	cragg	PROPN
biomedich-729	237	8	g.	g.	PROPN
biomedich-729	237	9	m.	m.	PROPN
biomedich-729	237	10	(	(	PUNCT
biomedich-729	237	11	2020	2020	NUM
biomedich-729	237	12	)	)	PUNCT
biomedich-729	237	13	natural	natural	ADJ
biomedich-729	237	14	products	product	NOUN
biomedich-729	237	15	as	as	ADP
biomedich-729	237	16	sources	source	NOUN
biomedich-729	237	17	of	of	ADP
biomedich-729	237	18	new	new	ADJ
biomedich-729	237	19	drugs	drug	NOUN
biomedich-729	237	20	over	over	ADP
biomedich-729	237	21	the	the	DET
biomedich-729	237	22	nearly	nearly	ADV
biomedich-729	237	23	four	four	NUM
biomedich-729	237	24	decades	decade	NOUN
biomedich-729	237	25	from	from	ADP
biomedich-729	237	26	01/1981	01/1981	NUM
biomedich-729	237	27	to	to	ADP
biomedich-729	237	28	09/2019	09/2019	PROPN
biomedich-729	237	29	.	.	PUNCT
biomedich-729	237	30	journal	journal	PROPN
biomedich-729	237	31	of	of	ADP
biomedich-729	237	32	natural	natural	ADJ
biomedich-729	237	33	products	product	NOUN
biomedich-729	237	34	,	,	PUNCT
biomedich-729	237	35	83(3):770	83(3):770	NOUN
biomedich-729	237	36	-	-	SYM
biomedich-729	237	37	803	803	NUM
biomedich-729	237	38	.	.	PUNCT
biomedich-729	238	1	https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b01285	https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b01285	PROPN
biomedich-729	238	2	ngoka	ngoka	PROPN
biomedich-729	238	3	,	,	PUNCT
biomedich-729	238	4	i.	i.	PROPN
biomedich-729	238	5	r.	r.	PROPN
biomedich-729	238	6	,	,	PUNCT
biomedich-729	238	7	chikwendu	chikwendu	NOUN
biomedich-729	238	8	,	,	PUNCT
biomedich-729	238	9	j.u	j.u	PROPN
biomedich-729	238	10	.	.	PROPN
biomedich-729	238	11	&	&	CCONJ
biomedich-729	238	12	maduforo	maduforo	PROPN
biomedich-729	238	13	,	,	PUNCT
biomedich-729	238	14	a.n	a.n	PROPN
biomedich-729	238	15	.	.	PROPN
biomedich-729	238	16	(	(	PUNCT
biomedich-729	238	17	2021	2021	NUM
biomedich-729	238	18	)	)	PUNCT
biomedich-729	238	19	consumption	consumption	NOUN
biomedich-729	238	20	and	and	CCONJ
biomedich-729	238	21	utilization	utilization	NOUN
biomedich-729	238	22	of	of	ADP
biomedich-729	238	23	fruits	fruit	NOUN
biomedich-729	238	24	,	,	PUNCT
biomedich-729	238	25	leaves	leave	NOUN
biomedich-729	238	26	and	and	CCONJ
biomedich-729	238	27	seeds	seed	NOUN
biomedich-729	238	28	of	of	ADP
biomedich-729	238	29	cola	cola	NOUN
biomedich-729	238	30	(	(	PUNCT
biomedich-729	238	31	pachycarpa	pachycarpa	NOUN
biomedich-729	238	32	and	and	CCONJ
biomedich-729	238	33	lepidota	lepidota	NOUN
biomedich-729	238	34	)	)	PUNCT
biomedich-729	238	35	in	in	ADP
biomedich-729	238	36	two	two	NUM
biomedich-729	238	37	south	south	ADJ
biomedich-729	238	38	eastern	eastern	ADJ
biomedich-729	238	39	states	state	NOUN
biomedich-729	238	40	of	of	ADP
biomedich-729	238	41	nigeria	nigeria	PROPN
biomedich-729	238	42	.	.	PUNCT
biomedich-729	239	1	journal	journal	PROPN
biomedich-729	239	2	of	of	ADP
biomedich-729	239	3	dietitians	dietitians	PROPN
biomedich-729	239	4	association	association	PROPN
biomedich-729	239	5	of	of	ADP
biomedich-729	239	6	nigeria	nigeria	PROPN
biomedich-729	239	7	,	,	PUNCT
biomedich-729	239	8	12	12	NUM
biomedich-729	239	9	.	.	PUNCT
biomedich-729	239	10	7282	7282	NUM
biomedich-729	239	11	.	.	PUNCT
biomedich-729	240	1	https://doi.org/10.4314/jdan.v12i1.10	https://doi.org/10.4314/jdan.v12i1.10	PROPN
biomedich-729	240	2	odion	odion	NOUN
biomedich-729	240	3	,	,	PUNCT
biomedich-729	240	4	e.	e.	PROPN
biomedich-729	240	5	e.	e.	PROPN
biomedich-729	240	6	,	,	PUNCT
biomedich-729	240	7	poh	poh	PROPN
biomedich-729	240	8	,	,	PUNCT
biomedich-729	240	9	c.	c.	PROPN
biomedich-729	240	10	f.	f.	PROPN
biomedich-729	240	11	,	,	PUNCT
biomedich-729	240	12	falodun	falodun	PROPN
biomedich-729	240	13	,	,	PUNCT
biomedich-729	240	14	a.	a.	NOUN
biomedich-729	240	15	&	&	CCONJ
biomedich-729	240	16	adelusi	adelusi	PROPN
biomedich-729	240	17	,	,	PUNCT
biomedich-729	240	18	s.	s.	PROPN
biomedich-729	240	19	a.	a.	PROPN
biomedich-729	240	20	(	(	PUNCT
biomedich-729	240	21	2013	2013	NUM
biomedich-729	240	22	)	)	PUNCT
biomedich-729	240	23	cola	cola	NOUN
biomedich-729	240	24	rostrata	rostrata	NOUN
biomedich-729	240	25	:	:	PUNCT
biomedich-729	240	26	phytochemical	phytochemical	ADJ
biomedich-729	240	27	and	and	CCONJ
biomedich-729	240	28	toxicity	toxicity	NOUN
biomedich-729	240	29	studies	study	NOUN
biomedich-729	240	30	.	.	PUNCT
biomedich-729	241	1	journal	journal	PROPN
biomedich-729	241	2	of	of	ADP
biomedich-729	241	3	applied	apply	VERB
biomedich-729	241	4	sciences	science	NOUN
biomedich-729	241	5	and	and	CCONJ
biomedich-729	241	6	environmental	environmental	ADJ
biomedich-729	241	7	management	management	NOUN
biomedich-729	241	8	,	,	PUNCT
biomedich-729	241	9	17(4):603607	17(4):603607	PROPN
biomedich-729	241	10	.	.	PUNCT
biomedich-729	242	1	https://www.bioline.org.br/pdf?ja13068	https://www.bioline.org.br/pdf?ja13068	PROPN
biomedich-729	242	2	ogu	ogu	PROPN
biomedich-729	242	3	,	,	PUNCT
biomedich-729	242	4	c.	c.	PROPN
biomedich-729	242	5	c.	c.	PROPN
biomedich-729	242	6	&	&	CCONJ
biomedich-729	242	7	maxa	maxa	PROPN
biomedich-729	242	8	,	,	PUNCT
biomedich-729	242	9	j.	j.	PROPN
biomedich-729	242	10	l.	l.	PROPN
biomedich-729	242	11	(	(	PUNCT
biomedich-729	242	12	2000	2000	NUM
biomedich-729	242	13	)	)	PUNCT
biomedich-729	242	14	drug	drug	NOUN
biomedich-729	242	15	interactions	interaction	NOUN
biomedich-729	242	16	due	due	ADP
biomedich-729	242	17	to	to	ADP
biomedich-729	242	18	cytochrome	cytochrome	VERB
biomedich-729	242	19	p450	p450	PROPN
biomedich-729	242	20	.	.	PUNCT
biomedich-729	243	1	proceedings	proceeding	NOUN
biomedich-729	243	2	baylor	baylor	PROPN
biomedich-729	243	3	university	university	PROPN
biomedich-729	243	4	.	.	PUNCT
biomedich-729	244	1	medical	medical	ADJ
biomedich-729	244	2	center	center	NOUN
biomedich-729	244	3	,	,	PUNCT
biomedich-729	244	4	13(4):421	13(4):421	PROPN
biomedich-729	244	5	-	-	SYM
biomedich-729	244	6	3	3	NUM
biomedich-729	244	7	.	.	PUNCT
biomedich-729	245	1	https://doi.org/10.1080/08998280.2000.11927719	https://doi.org/10.1080/08998280.2000.11927719	PROPN
biomedich-729	245	2	okaiyeto	okaiyeto	PROPN
biomedich-729	245	3	,	,	PUNCT
biomedich-729	245	4	k.	k.	PROPN
biomedich-729	245	5	&	&	CCONJ
biomedich-729	245	6	oguntibeju	oguntibeju	PROPN
biomedich-729	245	7	,	,	PUNCT
biomedich-729	245	8	o.	o.	NOUN
biomedich-729	245	9	o.	o.	PROPN
biomedich-729	245	10	(	(	PUNCT
biomedich-729	245	11	2021	2021	NUM
biomedich-729	245	12	)	)	PUNCT
biomedich-729	245	13	african	african	ADJ
biomedich-729	245	14	herbal	herbal	ADJ
biomedich-729	245	15	medicines	medicine	NOUN
biomedich-729	245	16	:	:	PUNCT
biomedich-729	245	17	adverse	adverse	ADJ
biomedich-729	245	18	effects	effect	NOUN
biomedich-729	245	19	and	and	CCONJ
biomedich-729	245	20	cytotoxic	cytotoxic	ADJ
biomedich-729	245	21	potentials	potential	NOUN
biomedich-729	245	22	with	with	ADP
biomedich-729	245	23	different	different	ADJ
biomedich-729	245	24	therapeutic	therapeutic	ADJ
biomedich-729	245	25	applications	application	NOUN
biomedich-729	245	26	.	.	PUNCT
biomedich-729	246	1	international	international	ADJ
biomedich-729	246	2	journal	journal	PROPN
biomedich-729	246	3	of	of	ADP
biomedich-729	246	4	environmental	environmental	ADJ
biomedich-729	246	5	research	research	NOUN
biomedich-729	246	6	and	and	CCONJ
biomedich-729	246	7	public	public	ADJ
biomedich-729	246	8	health	health	NOUN
biomedich-729	246	9	,	,	PUNCT
biomedich-729	246	10	18(11	18(11	NUM
biomedich-729	246	11	):	):	PUNCT
biomedich-729	246	12	5988	5988	NUM
biomedich-729	246	13	.	.	PUNCT
biomedich-729	247	1	https://doi.org/10.3390/ijerph18115988	https://doi.org/10.3390/ijerph18115988	PROPN
biomedich-729	247	2	osuntokun	osuntokun	PROPN
biomedich-729	247	3	,	,	PUNCT
biomedich-729	247	4	o.	o.	PROPN
biomedich-729	247	5	s.	s.	PROPN
biomedich-729	247	6	,	,	PUNCT
biomedich-729	247	7	akinsomisoye	akinsomisoye	PROPN
biomedich-729	247	8	,	,	PUNCT
biomedich-729	247	9	s.	s.	PROPN
biomedich-729	247	10	o.	o.	PROPN
biomedich-729	247	11	,	,	PUNCT
biomedich-729	247	12	olayiwola	olayiwola	PROPN
biomedich-729	247	13	,	,	PUNCT
biomedich-729	247	14	g.	g.	PROPN
biomedich-729	247	15	,	,	PUNCT
biomedich-729	247	16	adedokun	adedokun	PROPN
biomedich-729	247	17	,	,	PUNCT
biomedich-729	247	18	k.	k.	PROPN
biomedich-729	247	19	i.	i.	PROPN
biomedich-729	247	20	&	&	CCONJ
biomedich-729	247	21	oladokun	oladokun	PROPN
biomedich-729	247	22	,	,	PUNCT
biomedich-729	247	23	o.	o.	NOUN
biomedich-729	247	24	o.	o.	PROPN
biomedich-729	247	25	(	(	PUNCT
biomedich-729	247	26	2020	2020	NUM
biomedich-729	247	27	)	)	PUNCT
biomedich-729	247	28	carbamazepine	carbamazepine	NOUN
biomedich-729	247	29	adversely	adversely	ADV
biomedich-729	247	30	altered	alter	VERB
biomedich-729	247	31	the	the	DET
biomedich-729	247	32	pituitary	pituitary	ADJ
biomedich-729	247	33	–	–	PUNCT
biomedich-729	247	34	testicular	testicular	ADJ
biomedich-729	247	35	axis	axis	NOUN
biomedich-729	247	36	with	with	ADP
biomedich-729	247	37	resultant	resultant	VERB
biomedich-729	247	38	reproductive	reproductive	ADJ
biomedich-729	247	39	dysfunctions	dysfunction	NOUN
biomedich-729	247	40	than	than	ADP
biomedich-729	247	41	levetiracetam	levetiracetam	NOUN
biomedich-729	247	42	or	or	CCONJ
biomedich-729	247	43	carbamazepine	carbamazepine	NOUN
biomedich-729	247	44	–	–	PUNCT
biomedich-729	247	45	levetiracetam	levetiracetam	NOUN
biomedich-729	247	46	adjuvant	adjuvant	ADJ
biomedich-729	247	47	treatment	treatment	NOUN
biomedich-729	247	48	in	in	ADP
biomedich-729	247	49	male	male	PROPN
biomedich-729	247	50	wistar	wistar	PROPN
biomedich-729	247	51	rat	rat	PROPN
biomedich-729	247	52	.	.	PROPN
biomedich-729	247	53	andrologia	andrologia	PROPN
biomedich-729	247	54	.	.	PUNCT
biomedich-729	248	1	;	;	PUNCT
biomedich-729	248	2	52	52	NUM
biomedich-729	248	3	:	:	SYM
biomedich-729	248	4	e13871	e13871	INTJ
biomedich-729	248	5	.	.	PUNCT
biomedich-729	249	1	https://doi.org/10.1111/and.13871	https://doi.org/10.1111/and.13871	PROPN
biomedich-729	249	2	pivovarov	pivovarov	PROPN
biomedich-729	249	3	,	,	PUNCT
biomedich-729	249	4	a.	a.	NOUN
biomedich-729	249	5	s.	s.	PROPN
biomedich-729	249	6	,	,	PUNCT
biomedich-729	249	7	calahorro	calahorro	PROPN
biomedich-729	249	8	,	,	PUNCT
biomedich-729	249	9	f.	f.	PROPN
biomedich-729	249	10	&	&	CCONJ
biomedich-729	249	11	walker	walker	PROPN
biomedich-729	249	12	,	,	PUNCT
biomedich-729	249	13	r.	r.	PROPN
biomedich-729	249	14	j.	j.	PROPN
biomedich-729	249	15	(	(	PUNCT
biomedich-729	249	16	2019	2019	NUM
biomedich-729	249	17	)	)	PUNCT
biomedich-729	249	18	.	.	PUNCT
biomedich-729	250	1	na+/k+pump	na+/k+pump	NOUN
biomedich-729	250	2	and	and	CCONJ
biomedich-729	250	3	neurotransmitter	neurotransmitter	NOUN
biomedich-729	250	4	membrane	membrane	NOUN
biomedich-729	250	5	receptors	receptor	NOUN
biomedich-729	250	6	.	.	PUNCT
biomedich-729	251	1	invertebrate	invertebrate	ADJ
biomedich-729	251	2	neuroscience	neuroscience	NOUN
biomedich-729	251	3	,	,	PUNCT
biomedich-729	251	4	19	19	NUM
biomedich-729	251	5	,	,	PUNCT
biomedich-729	251	6	1	1	NUM
biomedich-729	251	7	.	.	X
biomedich-729	252	1	https://doi.org/10.1007/s10158-018-02217	https://doi.org/10.1007/s10158-018-02217	PROPN
biomedich-729	252	2	posadzki	posadzki	NOUN
biomedich-729	252	3	,	,	PUNCT
biomedich-729	252	4	p.	p.	PROPN
biomedich-729	252	5	,	,	PUNCT
biomedich-729	252	6	watson	watson	PROPN
biomedich-729	252	7	,	,	PUNCT
biomedich-729	252	8	l.	l.	PROPN
biomedich-729	252	9	k.	k.	PROPN
biomedich-729	252	10	&	&	CCONJ
biomedich-729	252	11	ernst	ernst	PROPN
biomedich-729	252	12	,	,	PUNCT
biomedich-729	252	13	e.	e.	PROPN
biomedich-729	252	14	(	(	PUNCT
biomedich-729	252	15	2013	2013	NUM
biomedich-729	252	16	)	)	PUNCT
biomedich-729	252	17	adverse	adverse	ADJ
biomedich-729	252	18	effects	effect	NOUN
biomedich-729	252	19	of	of	ADP
biomedich-729	252	20	herbal	herbal	ADJ
biomedich-729	252	21	medicines	medicine	NOUN
biomedich-729	252	22	:	:	PUNCT
biomedich-729	252	23	an	an	DET
biomedich-729	252	24	overview	overview	NOUN
biomedich-729	252	25	of	of	ADP
biomedich-729	252	26	systematic	systematic	ADJ
biomedich-729	252	27	reviews	review	NOUN
biomedich-729	252	28	,	,	PUNCT
biomedich-729	252	29	clinical	clinical	ADJ
biomedich-729	252	30	medicine	medicine	NOUN
biomedich-729	252	31	,	,	PUNCT
biomedich-729	252	32	13(1):7	13(1):7	NUM
biomedich-729	252	33	-	-	SYM
biomedich-729	252	34	12	12	NUM
biomedich-729	252	35	.	.	PUNCT
biomedich-729	253	1	https://doi.org/10.7861/clinmedicine.131-7	https://doi.org/10.7861/clinmedicine.131-7	PROPN
biomedich-729	253	2	qian	qian	PROPN
biomedich-729	253	3	,	,	PUNCT
biomedich-729	253	4	y.	y.	PROPN
biomedich-729	253	5	,	,	PUNCT
biomedich-729	253	6	yang	yang	PROPN
biomedich-729	253	7	,	,	PUNCT
biomedich-729	253	8	y.	y.	PROPN
biomedich-729	253	9	,	,	PUNCT
biomedich-729	253	10	wang	wang	PROPN
biomedich-729	253	11	,	,	PUNCT
biomedich-729	253	12	k.	k.	PROPN
biomedich-729	253	13	,	,	PUNCT
biomedich-729	253	14	zhou	zhou	PROPN
biomedich-729	253	15	,	,	PUNCT
biomedich-729	253	16	w.	w.	PROPN
biomedich-729	253	17	,	,	PUNCT
biomedich-729	253	18	dang	dang	PROPN
biomedich-729	253	19	,	,	PUNCT
biomedich-729	253	20	y.	y.	PROPN
biomedich-729	253	21	,	,	PUNCT
biomedich-729	253	22	zhu	zhu	PROPN
biomedich-729	253	23	,	,	PUNCT
biomedich-729	253	24	m.	m.	NOUN
biomedich-729	253	25	et	et	PROPN
biomedich-729	253	26	al	al	PROPN
biomedich-729	253	27	.	.	PROPN
biomedich-729	254	1	(	(	PUNCT
biomedich-729	254	2	2019	2019	NUM
biomedich-729	254	3	)	)	PUNCT
biomedich-729	254	4	2'-hydroxychalcone	2'-hydroxychalcone	NUM
biomedich-729	254	5	induced	induce	VERB
biomedich-729	254	6	cytotoxicity	cytotoxicity	NOUN
biomedich-729	254	7	via	via	ADP
biomedich-729	254	8	oxidative	oxidative	ADJ
biomedich-729	254	9	stress	stress	NOUN
biomedich-729	254	10	in	in	ADP
biomedich-729	254	11	the	the	DET
biomedich-729	254	12	lipid	lipid	NOUN
biomedich-729	254	13	-	-	PUNCT
biomedich-729	254	14	loaded	load	VERB
biomedich-729	254	15	hepg2	hepg2	NOUN
biomedich-729	254	16	cells	cell	NOUN
biomedich-729	254	17	.	.	PUNCT
biomedich-729	255	1	frontiers	frontier	NOUN
biomedich-729	255	2	in	in	ADP
biomedich-729	255	3	pharmacology	pharmacology	NOUN
biomedich-729	255	4	,	,	PUNCT
biomedich-729	255	5	10:1390	10:1390	NUM
biomedich-729	255	6	.	.	PUNCT
biomedich-729	256	1	https://doi.org/10.3389/fphar.2019.01390	https://doi.org/10.3389/fphar.2019.01390	PROPN
biomedich-729	256	2	ren	ren	PROPN
biomedich-729	256	3	,	,	PUNCT
biomedich-729	256	4	y.	y.	PROPN
biomedich-729	256	5	,	,	PUNCT
biomedich-729	256	6	anderson	anderson	PROPN
biomedich-729	256	7	,	,	PUNCT
biomedich-729	256	8	a.	a.	PROPN
biomedich-729	256	9	t.	t.	PROPN
biomedich-729	256	10	,	,	PUNCT
biomedich-729	256	11	meyer	meyer	PROPN
biomedich-729	256	12	,	,	PUNCT
biomedich-729	256	13	g.	g.	PROPN
biomedich-729	256	14	,	,	PUNCT
biomedich-729	256	15	lauber	lauber	PROPN
biomedich-729	256	16	,	,	PUNCT
biomedich-729	256	17	k.	k.	PROPN
biomedich-729	256	18	m.	m.	PROPN
biomedich-729	256	19	,	,	PUNCT
biomedich-729	256	20	gallucci	gallucci	PROPN
biomedich-729	256	21	j.	j.	PROPN
biomedich-729	256	22	c.	c.	PROPN
biomedich-729	256	23	,	,	PUNCT
biomedich-729	256	24	a.	a.	PROPN
biomedich-729	256	25	&	&	CCONJ
biomedich-729	256	26	kinghorn	kinghorn	PROPN
biomedich-729	256	27	d.	d.	PROPN
biomedich-729	256	28	(	(	PUNCT
biomedich-729	256	29	2024	2024	NUM
biomedich-729	256	30	)	)	PUNCT
biomedich-729	256	31	digoxin	digoxin	NOUN
biomedich-729	256	32	and	and	CCONJ
biomedich-729	256	33	its	its	PRON
biomedich-729	256	34	na+/k+atpase	na+/k+atpase	NUM
biomedich-729	256	35	-	-	PUNCT
biomedich-729	256	36	targeted	target	VERB
biomedich-729	256	37	actions	action	NOUN
biomedich-729	256	38	on	on	ADP
biomedich-729	256	39	cardiovascular	cardiovascular	ADJ
biomedich-729	256	40	diseases	disease	NOUN
biomedich-729	256	41	and	and	CCONJ
biomedich-729	256	42	cancer	cancer	NOUN
biomedich-729	256	43	,	,	PUNCT
biomedich-729	256	44	bioorganic	bioorganic	NOUN
biomedich-729	256	45	&	&	CCONJ
biomedich-729	256	46	medicinal	medicinal	PROPN
biomedich-729	256	47	chemistry,114	chemistry,114	PROPN
biomedich-729	256	48	,	,	PUNCT
biomedich-729	256	49	117939	117939	NUM
biomedich-729	256	50	.	.	PUNCT
biomedich-729	257	1	https://doi.org/10.1016/j.bmc.2024.117939	https://doi.org/10.1016/j.bmc.2024.117939	PROPN
biomedich-729	257	2	sahidin	sahidin	NOUN
biomedich-729	257	3	,	,	PUNCT
biomedich-729	257	4	n.	n.	NOUN
biomedich-729	257	5	,	,	PUNCT
biomedich-729	257	6	sani	sani	PROPN
biomedich-729	257	7	a.	a.	PROPN
biomedich-729	257	8	,	,	PUNCT
biomedich-729	257	9	anggrenimanggau	anggrenimanggau	VERB
biomedich-729	257	10	m.	m.	NOUN
biomedich-729	257	11	,	,	PUNCT
biomedich-729	257	12	sukohar	sukohar	PROPN
biomedich-729	257	13	a.	a.	NOUN
biomedich-729	257	14	,	,	PUNCT
biomedich-729	257	15	widodo	widodo	PROPN
biomedich-729	257	16	h.	h.	PROPN
biomedich-729	257	17	&	&	CCONJ
biomedich-729	257	18	baharum	baharum	PROPN
biomedich-729	257	19	s.	s.	PROPN
biomedich-729	257	20	(	(	PUNCT
biomedich-729	257	21	2014	2014	NUM
biomedich-729	257	22	)	)	PUNCT
biomedich-729	257	23	radical	radical	ADJ
biomedich-729	257	24	scavenging	scavenge	VERB
biomedich-729	257	25	activity	activity	NOUN
biomedich-729	257	26	of	of	ADP
biomedich-729	257	27	triterpene	triterpene	ADJ
biomedich-729	257	28	steroids	steroid	NOUN
biomedich-729	257	29	from	from	ADP
biomedich-729	257	30	stem	stem	NOUN
biomedich-729	257	31	of	of	ADP
biomedich-729	257	32	polygonum	polygonum	ADJ
biomedich-729	257	33	pulchrum	pulchrum	PROPN
biomedich-729	257	34	bi	bi	PROPN
biomedich-729	257	35	.	.	PROPN
biomedich-729	258	1	international	international	ADJ
biomedich-729	258	2	journal	journal	PROPN
biomedich-729	258	3	of	of	ADP
biomedich-729	258	4	pharmacy	pharmacy	NOUN
biomedich-729	258	5	and	and	CCONJ
biomedich-729	258	6	pharmaceutical	pharmaceutical	NOUN
biomedich-729	258	7	sciences	science	NOUN
biomedich-729	258	8	,	,	PUNCT
biomedich-729	258	9	6(8	6(8	NUM
biomedich-729	258	10	):	):	PUNCT
biomedich-729	258	11	350	350	NUM
biomedich-729	258	12	-	-	SYM
biomedich-729	258	13	354	354	NUM
biomedich-729	258	14	.	.	PUNCT
biomedich-729	259	1	serra	serra	PROPN
biomedich-729	259	2	-	-	PUNCT
biomedich-729	259	3	burriel	burriel	PROPN
biomedich-729	259	4	,	,	PUNCT
biomedich-729	259	5	m.	m.	NOUN
biomedich-729	259	6	,	,	PUNCT
biomedich-729	259	7	perényi	perényi	NOUN
biomedich-729	259	8	,	,	PUNCT
biomedich-729	259	9	g.	g.	PROPN
biomedich-729	259	10	,	,	PUNCT
biomedich-729	259	11	laube	laube	PROPN
biomedich-729	259	12	,	,	PUNCT
biomedich-729	259	13	y.	y.	PROPN
biomedich-729	259	14	,	,	PUNCT
biomedich-729	259	15	mitchell	mitchell	PROPN
biomedich-729	259	16	,	,	PUNCT
biomedich-729	259	17	a.	a.	NOUN
biomedich-729	259	18	p.	p.	PROPN
biomedich-729	259	19	,	,	PUNCT
biomedich-729	259	20	&	&	CCONJ
biomedich-729	259	21	vokingera	vokingera	PROPN
biomedich-729	259	22	,	,	PUNCT
biomedich-729	259	23	k	k	PROPN
biomedich-729	259	24	n.	n.	PROPN
biomedich-729	259	25	(	(	PUNCT
biomedich-729	259	26	2023	2023	NUM
biomedich-729	259	27	)	)	PUNCT
biomedich-729	259	28	the	the	DET
biomedich-729	259	29	cancer	cancer	NOUN
biomedich-729	259	30	premium	premium	NOUN
biomedich-729	259	31	–	–	PUNCT
biomedich-729	259	32	explaining	explain	VERB
biomedich-729	259	33	differences	difference	NOUN
biomedich-729	259	34	in	in	ADP
biomedich-729	259	35	prices	price	NOUN
biomedich-729	259	36	for	for	ADP
biomedich-729	259	37	cancer	cancer	NOUN
biomedich-729	259	38	vs	vs	ADP
biomedich-729	259	39	non	non	ADJ
biomedich-729	259	40	-	-	ADJ
biomedich-729	259	41	cancer	cancer	ADJ
biomedich-729	259	42	drugs	drug	NOUN
biomedich-729	259	43	with	with	ADP
biomedich-729	259	44	efficacy	efficacy	NOUN
biomedich-729	259	45	and	and	CCONJ
biomedich-729	259	46	epidemiological	epidemiological	ADJ
biomedich-729	259	47	endpoints	endpoint	NOUN
biomedich-729	259	48	in	in	ADP
biomedich-729	259	49	the	the	DET
biomedich-729	259	50	us	us	PROPN
biomedich-729	259	51	,	,	PUNCT
biomedich-729	259	52	germany	germany	PROPN
biomedich-729	259	53	,	,	PUNCT
biomedich-729	259	54	and	and	CCONJ
biomedich-729	259	55	switzerland	switzerland	PROPN
biomedich-729	259	56	:	:	PUNCT
biomedich-729	259	57	a	a	DET
biomedich-729	259	58	cross	cross	ADJ
biomedich-729	259	59	sectional	sectional	ADJ
biomedich-729	259	60	study	study	NOUN
biomedich-729	259	61	.	.	PUNCT
biomedich-729	260	1	eclinical	eclinical	ADJ
biomedich-729	260	2	medicine	medicine	NOUN
biomedich-729	260	3	,	,	PUNCT
biomedich-729	260	4	61	61	NUM
biomedich-729	260	5	:	:	SYM
biomedich-729	260	6	102087	102087	NUM
biomedich-729	260	7	.	.	PUNCT
biomedich-729	261	1	https://doi.org/10.1016/j.eclinm.2023.102087	https://doi.org/10.1016/j.eclinm.2023.102087	PROPN
biomedich-729	261	2	shin	shin	PROPN
biomedich-729	261	3	,	,	PUNCT
biomedich-729	261	4	g.	g.	PROPN
biomedich-729	261	5	,	,	PUNCT
biomedich-729	261	6	kwon	kwon	PROPN
biomedich-729	261	7	,	,	PUNCT
biomedich-729	261	8	h.	h.	PROPN
biomedich-729	261	9	y.	y.	PROPN
biomedich-729	261	10	&	&	CCONJ
biomedich-729	261	11	bae	bae	PROPN
biomedich-729	261	12	,	,	PUNCT
biomedich-729	261	13	s.	s.	PROPN
biomedich-729	261	14	(	(	PUNCT
biomedich-729	261	15	2022	2022	NUM
biomedich-729	261	16	)	)	PUNCT
biomedich-729	261	17	for	for	ADP
biomedich-729	261	18	whom	whom	PRON
biomedich-729	261	19	the	the	DET
biomedich-729	261	20	price	price	NOUN
biomedich-729	261	21	escalates	escalate	VERB
biomedich-729	261	22	:	:	PUNCT
biomedich-729	261	23	high	high	ADJ
biomedich-729	261	24	price	price	NOUN
biomedich-729	261	25	and	and	CCONJ
biomedich-729	261	26	uncertain	uncertain	ADJ
biomedich-729	261	27	value	value	NOUN
biomedich-729	261	28	of	of	ADP
biomedich-729	261	29	cancer	cancer	NOUN
biomedich-729	261	30	drugs	drug	NOUN
biomedich-729	261	31	.	.	PUNCT
biomedich-729	262	1	international	international	ADJ
biomedich-729	262	2	journal	journal	PROPN
biomedich-729	262	3	of	of	ADP
biomedich-729	262	4	environmental	environmental	ADJ
biomedich-729	262	5	research	research	NOUN
biomedich-729	262	6	and	and	CCONJ
biomedich-729	262	7	public	public	ADJ
biomedich-729	262	8	health	health	NOUN
biomedich-729	262	9	,	,	PUNCT
biomedich-729	262	10	19(7):4204	19(7):4204	PROPN
biomedich-729	262	11	.	.	PUNCT
biomedich-729	263	1	https://doi.org/10.3390/ijerph19074204	https://doi.org/10.3390/ijerph19074204	PROPN
biomedich-729	263	2	uduwana	uduwana	PROPN
biomedich-729	263	3	,	,	PUNCT
biomedich-729	263	4	s.	s.	PROPN
biomedich-729	263	5	,	,	PUNCT
biomedich-729	263	6	abeynayake	abeynayake	ADJ
biomedich-729	263	7	,	,	PUNCT
biomedich-729	263	8	n.	n.	PROPN
biomedich-729	263	9	&	&	CCONJ
biomedich-729	263	10	wickramasinghe	wickramasinghe	PROPN
biomedich-729	263	11	i.	i.	PROPN
biomedich-729	263	12	(	(	PUNCT
biomedich-729	263	13	2023	2023	NUM
biomedich-729	263	14	)	)	PUNCT
biomedich-729	263	15	synergistic	synergistic	ADJ
biomedich-729	263	16	,	,	PUNCT
biomedich-729	263	17	antagonistic	antagonistic	ADJ
biomedich-729	263	18	,	,	PUNCT
biomedich-729	263	19	and	and	CCONJ
biomedich-729	263	20	additive	additive	ADJ
biomedich-729	263	21	effects	effect	NOUN
biomedich-729	263	22	on	on	ADP
biomedich-729	263	23	the	the	DET
biomedich-729	263	24	resultant	resultant	NOUN
biomedich-729	263	25	antioxidant	antioxidant	ADJ
biomedich-729	263	26	activity	activity	NOUN
biomedich-729	263	27	in	in	ADP
biomedich-729	263	28	infusions	infusion	NOUN
biomedich-729	263	29	of	of	ADP
biomedich-729	263	30	green	green	ADJ
biomedich-729	263	31	tea	tea	NOUN
biomedich-729	263	32	with	with	ADP
biomedich-729	263	33	bee	bee	PROPN
biomedich-729	263	34	honey	honey	PROPN
biomedich-729	263	35	and	and	CCONJ
biomedich-729	263	36	citrus	citrus	VERB
biomedich-729	263	37	limonum	limonum	ADJ
biomedich-729	263	38	extract	extract	NOUN
biomedich-729	263	39	as	as	ADP
biomedich-729	263	40	additives	additive	NOUN
biomedich-729	263	41	,	,	PUNCT
biomedich-729	263	42	journal	journal	NOUN
biomedich-729	263	43	of	of	ADP
biomedich-729	263	44	agriculture	agriculture	NOUN
biomedich-729	263	45	and	and	CCONJ
biomedich-729	263	46	food	food	NOUN
biomedich-729	263	47	research	research	NOUN
biomedich-729	263	48	,	,	PUNCT
biomedich-729	263	49	volume	volume	NOUN
biomedich-729	263	50	12	12	NUM
biomedich-729	263	51	,	,	PUNCT
biomedich-729	263	52	2023,100571	2023,100571	NUM
biomedich-729	263	53	.	.	PUNCT
biomedich-729	264	1	https://doi.org/10.1016/j.jafr.2023.100571	https://doi.org/10.1016/j.jafr.2023.100571	PROPN
biomedich-729	264	2	vaezi	vaezi	PROPN
biomedich-729	264	3	,	,	PUNCT
biomedich-729	264	4	a.	a.	NOUN
biomedich-729	264	5	a.	a.	PROPN
biomedich-729	264	6	,	,	PUNCT
biomedich-729	264	7	sotoudeh	sotoudeh	PROPN
biomedich-729	264	8	,	,	PUNCT
biomedich-729	264	9	a.	a.	NOUN
biomedich-729	264	10	,	,	PUNCT
biomedich-729	264	11	namiranian	namiranian	PROPN
biomedich-729	264	12	,	,	PUNCT
biomedich-729	264	13	n.	n.	PROPN
biomedich-729	264	14	,	,	PUNCT
biomedich-729	264	15	ardakani	ardakani	PROPN
biomedich-729	264	16	,	,	PUNCT
biomedich-729	264	17	m.	m.	PROPN
biomedich-729	264	18	f.	f.	PROPN
biomedich-729	264	19	&	&	CCONJ
biomedich-729	264	20	zareipour	zareipour	PROPN
biomedich-729	264	21	m.	m.	PROPN
biomedich-729	264	22	(	(	PUNCT
biomedich-729	264	23	2021	2021	NUM
biomedich-729	264	24	)	)	PUNCT
biomedich-729	264	25	facilitators	facilitator	NOUN
biomedich-729	264	26	and	and	CCONJ
biomedich-729	264	27	barriers	barrier	NOUN
biomedich-729	264	28	of	of	ADP
biomedich-729	264	29	herbal	herbal	ADJ
biomedich-729	264	30	medicine	medicine	NOUN
biomedich-729	264	31	use	use	NOUN
biomedich-729	264	32	in	in	ADP
biomedich-729	264	33	diabetic	diabetic	ADJ
biomedich-729	264	34	patients	patient	NOUN
biomedich-729	264	35	:	:	PUNCT
biomedich-729	264	36	a	a	DET
biomedich-729	264	37	qualitative	qualitative	ADJ
biomedich-729	264	38	study	study	NOUN
biomedich-729	264	39	.	.	PUNCT
biomedich-729	265	1	journal	journal	PROPN
biomedich-729	265	2	of	of	ADP
biomedich-729	265	3	education	education	NOUN
biomedich-729	265	4	and	and	CCONJ
biomedich-729	265	5	health	health	NOUN
biomedich-729	265	6	promotion	promotion	NOUN
biomedich-729	265	7	,	,	PUNCT
biomedich-729	265	8	10:303	10:303	NUM
biomedich-729	265	9	.	.	PUNCT
biomedich-729	266	1	https://doi.org/10.4103/jehp.jehp_1451_20	https://doi.org/10.4103/jehp.jehp_1451_20	NOUN
biomedich-729	266	2	vasques	vasque	NOUN
biomedich-729	266	3	,	,	PUNCT
biomedich-729	266	4	a.	a.	NOUN
biomedich-729	266	5	,	,	PUNCT
biomedich-729	266	6	cavaco	cavaco	PROPN
biomedich-729	266	7	,	,	PUNCT
biomedich-729	266	8	p.	p.	PROPN
biomedich-729	266	9	,	,	PUNCT
biomedich-729	266	10	duarte	duarte	PROPN
biomedich-729	266	11	,	,	PUNCT
biomedich-729	266	12	t.	t.	PROPN
biomedich-729	266	13	,	,	PUNCT
biomedich-729	266	14	branco	branco	PROPN
biomedich-729	266	15	,	,	PUNCT
biomedich-729	266	16	d.	d.	PROPN
biomedich-729	266	17	v.	v.	PROPN
biomedich-729	266	18	,	,	PUNCT
biomedich-729	266	19	baleiras	baleiras	PROPN
biomedich-729	266	20	,	,	PUNCT
biomedich-729	266	21	m.	m.	NOUN
biomedich-729	266	22	m.	m.	NOUN
biomedich-729	266	23	,	,	PUNCT
biomedich-729	266	24	pinto	pinto	NOUN
biomedich-729	266	25	,	,	PUNCT
biomedich-729	266	26	m.	m.	NOUN
biomedich-729	266	27	et	et	PROPN
biomedich-729	266	28	al	al	PROPN
biomedich-729	266	29	.	.	PROPN
biomedich-729	267	1	(	(	PUNCT
biomedich-729	267	2	2024	2024	NUM
biomedich-729	267	3	)	)	PUNCT
biomedich-729	267	4	the	the	DET
biomedich-729	267	5	use	use	NOUN
biomedich-729	267	6	of	of	ADP
biomedich-729	267	7	herbal	herbal	ADJ
biomedich-729	267	8	medicines	medicine	NOUN
biomedich-729	267	9	among	among	ADP
biomedich-729	267	10	cancer	cancer	NOUN
biomedich-729	267	11	patients	patient	NOUN
biomedich-729	267	12	.	.	PUNCT
biomedich-729	268	1	cureus	cureus	PROPN
biomedich-729	268	2	16(2	16(2	NUM
biomedich-729	268	3	):	):	PUNCT
biomedich-729	268	4	e53455	e53455	PROPN
biomedich-729	268	5	.	.	PUNCT
biomedich-729	269	1	https://doi.org/10.7759/cureus.53455	https://doi.org/10.7759/cureus.53455	NOUN
biomedich-729	269	2	this	this	DET
biomedich-729	269	3	page	page	NOUN
biomedich-729	269	4	intentionally	intentionally	ADV
biomedich-729	269	5	left	leave	VERB
biomedich-729	269	6	blank	blank	ADV