id	sid	tid	token	lemma	pos
biomedich-731	1	1	biology	biology	NOUN
biomedich-731	1	2	,	,	PUNCT
biomedich-731	1	3	medicine	medicine	NOUN
biomedich-731	1	4	,	,	PUNCT
biomedich-731	1	5	&	&	CCONJ
biomedich-731	1	6	natural	natural	ADJ
biomedich-731	1	7	product	product	NOUN
biomedich-731	1	8	chemistry	chemistry	NOUN
biomedich-731	1	9	issn	issn	VERB
biomedich-731	1	10	2089	2089	NUM
biomedich-731	1	11	-	-	SYM
biomedich-731	1	12	6514	6514	NUM
biomedich-731	1	13	(	(	PUNCT
biomedich-731	1	14	paper	paper	NOUN
biomedich-731	1	15	)	)	PUNCT
biomedich-731	1	16	volume	volume	NOUN
biomedich-731	1	17	14	14	NUM
biomedich-731	1	18	,	,	PUNCT
biomedich-731	1	19	number	number	NOUN
biomedich-731	1	20	1	1	NUM
biomedich-731	1	21	,	,	PUNCT
biomedich-731	1	22	april	april	PROPN
biomedich-731	1	23	2025	2025	NUM
biomedich-731	1	24	|	|	ADV
biomedich-731	1	25	pages	page	NOUN
biomedich-731	1	26	:	:	PUNCT
biomedich-731	1	27	409	409	NUM
biomedich-731	1	28	-	-	SYM
biomedich-731	1	29	415	415	NUM
biomedich-731	1	30	|	|	ADV
biomedich-731	1	31	doi	doi	NOUN
biomedich-731	1	32	:	:	PUNCT
biomedich-731	1	33	10.14421	10.14421	NUM
biomedich-731	1	34	/	/	SYM
biomedich-731	1	35	biomedich.2025.141.409	biomedich.2025.141.409	NOUN
biomedich-731	1	36	-	-	PUNCT
biomedich-731	1	37	415	415	NUM
biomedich-731	1	38	issn	issn	NOUN
biomedich-731	1	39	2540	2540	NUM
biomedich-731	1	40	-	-	SYM
biomedich-731	1	41	9328	9328	NUM
biomedich-731	1	42	(	(	PUNCT
biomedich-731	1	43	online	online	NOUN
biomedich-731	1	44	)	)	PUNCT
biomedich-731	1	45	4	4	NUM
biomedich-731	1	46	-	-	PUNCT
biomedich-731	1	47	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	1	48	as	as	ADP
biomedich-731	1	49	a	a	DET
biomedich-731	1	50	natural	natural	ADJ
biomedich-731	1	51	dpp-4	dpp-4	ADJ
biomedich-731	1	52	inhibitor	inhibitor	NOUN
biomedich-731	1	53	for	for	ADP
biomedich-731	1	54	diabetes	diabetes	NOUN
biomedich-731	1	55	amir	amir	X
biomedich-731	1	56	thalib1	thalib1	PROPN
biomedich-731	1	57	,	,	PUNCT
biomedich-731	1	58	*	*	PROPN
biomedich-731	1	59	,	,	PUNCT
biomedich-731	1	60	irma	irma	PROPN
biomedich-731	1	61	putri	putri	PROPN
biomedich-731	1	62	damayanti2	damayanti2	PUNCT
biomedich-731	2	1	1department	1department	NUM
biomedich-731	2	2	of	of	ADP
biomedich-731	2	3	medicine	medicine	NOUN
biomedich-731	2	4	;	;	PUNCT
biomedich-731	3	1	2department	2department	NUM
biomedich-731	3	2	of	of	ADP
biomedich-731	3	3	herbal	herbal	ADJ
biomedich-731	3	4	medicine	medicine	NOUN
biomedich-731	3	5	,	,	PUNCT
biomedich-731	3	6	faculty	faculty	NOUN
biomedich-731	3	7	of	of	ADP
biomedich-731	3	8	medicine	medicine	NOUN
biomedich-731	3	9	;	;	PUNCT
biomedich-731	3	10	university	university	NOUN
biomedich-731	3	11	of	of	ADP
biomedich-731	3	12	muhammadiyah	muhammadiyah	NOUN
biomedich-731	3	13	purwokerto	purwokerto	PROPN
biomedich-731	3	14	jl	jl	PROPN
biomedich-731	3	15	.	.	PUNCT
biomedich-731	4	1	kh	kh	PROPN
biomedich-731	4	2	.	.	PUNCT
biomedich-731	4	3	ahmad	ahmad	PROPN
biomedich-731	4	4	dahlan	dahlan	PROPN
biomedich-731	4	5	,	,	PUNCT
biomedich-731	4	6	purwokerto	purwokerto	PROPN
biomedich-731	4	7	53182	53182	NUM
biomedich-731	4	8	,	,	PUNCT
biomedich-731	4	9	indonesia	indonesia	PROPN
biomedich-731	4	10	.	.	PUNCT
biomedich-731	5	1	corresponding	correspond	VERB
biomedich-731	5	2	author	author	NOUN
biomedich-731	5	3	*	*	PUNCT
biomedich-731	5	4	amirthalib18@gmail.com	amirthalib18@gmail.com	X
biomedich-731	5	5	manuscript	manuscript	NOUN
biomedich-731	5	6	received	receive	VERB
biomedich-731	5	7	:	:	PUNCT
biomedich-731	5	8	28	28	NUM
biomedich-731	5	9	february	february	PROPN
biomedich-731	5	10	,	,	PUNCT
biomedich-731	5	11	2025	2025	NUM
biomedich-731	5	12	.	.	PUNCT
biomedich-731	6	1	revision	revision	NOUN
biomedich-731	6	2	accepted	accept	VERB
biomedich-731	6	3	:	:	PUNCT
biomedich-731	6	4	20	20	NUM
biomedich-731	6	5	may	may	NOUN
biomedich-731	6	6	,	,	PUNCT
biomedich-731	6	7	2025	2025	NUM
biomedich-731	6	8	.	.	PUNCT
biomedich-731	7	1	published	publish	VERB
biomedich-731	7	2	:	:	PUNCT
biomedich-731	7	3	16	16	NUM
biomedich-731	7	4	july	july	PROPN
biomedich-731	7	5	,	,	PUNCT
biomedich-731	7	6	2025	2025	NUM
biomedich-731	7	7	.	.	PUNCT
biomedich-731	8	1	abstract	abstract	ADJ
biomedich-731	8	2	research	research	NOUN
biomedich-731	8	3	on	on	ADP
biomedich-731	8	4	4	4	NUM
biomedich-731	8	5	-	-	PUNCT
biomedich-731	8	6	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	8	7	,	,	PUNCT
biomedich-731	8	8	a	a	DET
biomedich-731	8	9	natural	natural	ADJ
biomedich-731	8	10	compound	compound	NOUN
biomedich-731	8	11	found	find	VERB
biomedich-731	8	12	in	in	ADP
biomedich-731	8	13	several	several	ADJ
biomedich-731	8	14	plant	plant	NOUN
biomedich-731	8	15	sources	source	NOUN
biomedich-731	8	16	,	,	PUNCT
biomedich-731	8	17	shows	show	VERB
biomedich-731	8	18	potential	potential	ADJ
biomedich-731	8	19	as	as	ADP
biomedich-731	8	20	an	an	DET
biomedich-731	8	21	antidiabetic	antidiabetic	ADJ
biomedich-731	8	22	agent	agent	NOUN
biomedich-731	8	23	through	through	ADP
biomedich-731	8	24	inhibiting	inhibit	VERB
biomedich-731	8	25	the	the	DET
biomedich-731	8	26	dpp-4	dpp-4	ADV
biomedich-731	8	27	(	(	PUNCT
biomedich-731	8	28	dipeptidyl	dipeptidyl	ADJ
biomedich-731	8	29	peptidase-4	peptidase-4	NOUN
biomedich-731	8	30	)	)	PUNCT
biomedich-731	8	31	enzyme	enzyme	NOUN
biomedich-731	8	32	.	.	PUNCT
biomedich-731	9	1	this	this	DET
biomedich-731	9	2	study	study	NOUN
biomedich-731	9	3	evaluates	evaluate	VERB
biomedich-731	9	4	the	the	DET
biomedich-731	9	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	9	6	potential	potential	ADJ
biomedich-731	9	7	and	and	CCONJ
biomedich-731	9	8	toxicity	toxicity	NOUN
biomedich-731	9	9	profile	profile	NOUN
biomedich-731	9	10	of	of	ADP
biomedich-731	9	11	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	9	12	as	as	ADP
biomedich-731	9	13	a	a	DET
biomedich-731	9	14	therapeutic	therapeutic	ADJ
biomedich-731	9	15	agent	agent	NOUN
biomedich-731	9	16	.	.	PUNCT
biomedich-731	10	1	adme	adme	NOUN
biomedich-731	10	2	(	(	PUNCT
biomedich-731	10	3	absorption	absorption	NOUN
biomedich-731	10	4	,	,	PUNCT
biomedich-731	10	5	distribution	distribution	NOUN
biomedich-731	10	6	,	,	PUNCT
biomedich-731	10	7	metabolism	metabolism	NOUN
biomedich-731	10	8	,	,	PUNCT
biomedich-731	10	9	excretion	excretion	NOUN
biomedich-731	10	10	)	)	PUNCT
biomedich-731	10	11	analysis	analysis	NOUN
biomedich-731	10	12	indicates	indicate	VERB
biomedich-731	10	13	that	that	SCONJ
biomedich-731	10	14	this	this	DET
biomedich-731	10	15	compound	compound	NOUN
biomedich-731	10	16	has	have	VERB
biomedich-731	10	17	good	good	ADJ
biomedich-731	10	18	gastrointestinal	gastrointestinal	ADJ
biomedich-731	10	19	absorption	absorption	NOUN
biomedich-731	10	20	,	,	PUNCT
biomedich-731	10	21	moderate	moderate	ADJ
biomedich-731	10	22	water	water	NOUN
biomedich-731	10	23	solubility	solubility	NOUN
biomedich-731	10	24	,	,	PUNCT
biomedich-731	10	25	and	and	CCONJ
biomedich-731	10	26	limited	limited	ADJ
biomedich-731	10	27	penetration	penetration	NOUN
biomedich-731	10	28	across	across	ADP
biomedich-731	10	29	the	the	DET
biomedich-731	10	30	blood	blood	NOUN
biomedich-731	10	31	-	-	PUNCT
biomedich-731	10	32	brain	brain	NOUN
biomedich-731	10	33	barrier	barrier	NOUN
biomedich-731	10	34	,	,	PUNCT
biomedich-731	10	35	which	which	PRON
biomedich-731	10	36	reduces	reduce	VERB
biomedich-731	10	37	the	the	DET
biomedich-731	10	38	risk	risk	NOUN
biomedich-731	10	39	of	of	ADP
biomedich-731	10	40	central	central	ADJ
biomedich-731	10	41	nervous	nervous	ADJ
biomedich-731	10	42	system	system	NOUN
biomedich-731	10	43	side	side	NOUN
biomedich-731	10	44	effects	effect	NOUN
biomedich-731	10	45	.	.	PUNCT
biomedich-731	11	1	the	the	DET
biomedich-731	11	2	toxicity	toxicity	NOUN
biomedich-731	11	3	profile	profile	NOUN
biomedich-731	11	4	of	of	ADP
biomedich-731	11	5	4	4	NUM
biomedich-731	11	6	-	-	PUNCT
biomedich-731	11	7	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	11	8	reveals	reveal	VERB
biomedich-731	11	9	low	low	ADJ
biomedich-731	11	10	hepatotoxicity	hepatotoxicity	NOUN
biomedich-731	11	11	,	,	PUNCT
biomedich-731	11	12	with	with	ADP
biomedich-731	11	13	no	no	DET
biomedich-731	11	14	indications	indication	NOUN
biomedich-731	11	15	of	of	ADP
biomedich-731	11	16	mutagenicity	mutagenicity	NOUN
biomedich-731	11	17	or	or	CCONJ
biomedich-731	11	18	carcinogenicity	carcinogenicity	NOUN
biomedich-731	11	19	.	.	PUNCT
biomedich-731	12	1	the	the	DET
biomedich-731	12	2	ld50	ld50	PROPN
biomedich-731	12	3	value	value	NOUN
biomedich-731	12	4	greater	great	ADJ
biomedich-731	12	5	than	than	ADP
biomedich-731	12	6	2000	2000	NUM
biomedich-731	12	7	mg	mg	PROPN
biomedich-731	12	8	/	/	SYM
biomedich-731	12	9	kg	kg	PROPN
biomedich-731	12	10	places	place	VERB
biomedich-731	12	11	this	this	DET
biomedich-731	12	12	compound	compound	NOUN
biomedich-731	12	13	in	in	ADP
biomedich-731	12	14	toxicity	toxicity	NOUN
biomedich-731	12	15	class	class	NOUN
biomedich-731	12	16	5	5	NUM
biomedich-731	12	17	,	,	PUNCT
biomedich-731	12	18	indicating	indicate	VERB
biomedich-731	12	19	low	low	ADJ
biomedich-731	12	20	toxicity	toxicity	NOUN
biomedich-731	12	21	.	.	PUNCT
biomedich-731	13	1	based	base	VERB
biomedich-731	13	2	on	on	ADP
biomedich-731	13	3	in	in	ADP
biomedich-731	13	4	silico	silico	NOUN
biomedich-731	13	5	evaluation	evaluation	NOUN
biomedich-731	13	6	results	result	NOUN
biomedich-731	13	7	,	,	PUNCT
biomedich-731	13	8	4	4	NUM
biomedich-731	13	9	-	-	PUNCT
biomedich-731	13	10	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	13	11	has	have	VERB
biomedich-731	13	12	potential	potential	ADJ
biomedich-731	13	13	as	as	ADP
biomedich-731	13	14	an	an	DET
biomedich-731	13	15	effective	effective	ADJ
biomedich-731	13	16	natural	natural	ADJ
biomedich-731	13	17	dpp-4	dpp-4	NUM
biomedich-731	13	18	inhibitor	inhibitor	NOUN
biomedich-731	13	19	,	,	PUNCT
biomedich-731	13	20	with	with	ADP
biomedich-731	13	21	stable	stable	ADJ
biomedich-731	13	22	binding	bind	VERB
biomedich-731	13	23	mechanisms	mechanism	NOUN
biomedich-731	13	24	,	,	PUNCT
biomedich-731	13	25	even	even	ADV
biomedich-731	13	26	though	though	SCONJ
biomedich-731	13	27	its	its	PRON
biomedich-731	13	28	binding	bind	VERB
biomedich-731	13	29	affinity	affinity	NOUN
biomedich-731	13	30	is	be	AUX
biomedich-731	13	31	lower	low	ADJ
biomedich-731	13	32	than	than	ADP
biomedich-731	13	33	synthetic	synthetic	ADJ
biomedich-731	13	34	inhibitors	inhibitor	NOUN
biomedich-731	13	35	.	.	PUNCT
biomedich-731	14	1	with	with	ADP
biomedich-731	14	2	favorable	favorable	ADJ
biomedich-731	14	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	14	4	properties	property	NOUN
biomedich-731	14	5	and	and	CCONJ
biomedich-731	14	6	a	a	DET
biomedich-731	14	7	beneficial	beneficial	ADJ
biomedich-731	14	8	safety	safety	NOUN
biomedich-731	14	9	profile	profile	NOUN
biomedich-731	14	10	,	,	PUNCT
biomedich-731	14	11	4	4	NUM
biomedich-731	14	12	-	-	NOUN
biomedich-731	14	13	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	14	14	has	have	VERB
biomedich-731	14	15	the	the	DET
biomedich-731	14	16	potential	potential	NOUN
biomedich-731	14	17	to	to	PART
biomedich-731	14	18	be	be	AUX
biomedich-731	14	19	developed	develop	VERB
biomedich-731	14	20	as	as	ADP
biomedich-731	14	21	a	a	DET
biomedich-731	14	22	natural	natural	ADJ
biomedich-731	14	23	therapeutic	therapeutic	ADJ
biomedich-731	14	24	agent	agent	NOUN
biomedich-731	14	25	for	for	ADP
biomedich-731	14	26	diabetes	diabetes	NOUN
biomedich-731	14	27	management	management	NOUN
biomedich-731	14	28	.	.	PUNCT
biomedich-731	15	1	keywords	keyword	NOUN
biomedich-731	15	2	:	:	PUNCT
biomedich-731	15	3	4	4	NUM
biomedich-731	15	4	-	-	NOUN
biomedich-731	15	5	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	15	6	;	;	PUNCT
biomedich-731	15	7	adme	adme	NOUN
biomedich-731	15	8	;	;	PUNCT
biomedich-731	15	9	toxicity	toxicity	NOUN
biomedich-731	15	10	profile	profile	NOUN
biomedich-731	15	11	;	;	PUNCT
biomedich-731	15	12	dpp-4	dpp-4	X
biomedich-731	15	13	;	;	PUNCT
biomedich-731	15	14	antidiabetic	antidiabetic	ADJ
biomedich-731	15	15	.	.	PUNCT
biomedich-731	16	1	abbreviations	abbreviation	NOUN
biomedich-731	16	2	:	:	PUNCT
biomedich-731	16	3	dpp-4	dpp-4	NUM
biomedich-731	16	4	:	:	PUNCT
biomedich-731	16	5	dipeptidyl	dipeptidyl	NOUN
biomedich-731	16	6	-	-	PUNCT
biomedich-731	16	7	peptidase	peptidase	NOUN
biomedich-731	16	8	4	4	NUM
biomedich-731	16	9	;	;	PUNCT
biomedich-731	16	10	gip	gip	NOUN
biomedich-731	16	11	:	:	PUNCT
biomedich-731	16	12	glucose	glucose	NOUN
biomedich-731	16	13	-	-	PUNCT
biomedich-731	16	14	dependent	dependent	ADJ
biomedich-731	16	15	insulinotropic	insulinotropic	NOUN
biomedich-731	16	16	polypeptide	polypeptide	ADJ
biomedich-731	16	17	;	;	PUNCT
biomedich-731	16	18	glp-1	glp-1	NUM
biomedich-731	16	19	:	:	PUNCT
biomedich-731	16	20	glucagon	glucagon	NOUN
biomedich-731	16	21	-	-	PUNCT
biomedich-731	16	22	like	like	ADJ
biomedich-731	16	23	peptide-1	peptide-1	PROPN
biomedich-731	16	24	introduction	introduction	NOUN
biomedich-731	16	25	a	a	DET
biomedich-731	16	26	major	major	ADJ
biomedich-731	16	27	therapeutic	therapeutic	ADJ
biomedich-731	16	28	target	target	NOUN
biomedich-731	16	29	in	in	ADP
biomedich-731	16	30	the	the	DET
biomedich-731	16	31	management	management	NOUN
biomedich-731	16	32	of	of	ADP
biomedich-731	16	33	type	type	NOUN
biomedich-731	16	34	2	2	NUM
biomedich-731	16	35	diabetes	diabetes	NOUN
biomedich-731	16	36	mellitus	mellitus	NOUN
biomedich-731	16	37	(	(	PUNCT
biomedich-731	16	38	t2	t2	NOUN
biomedich-731	16	39	dm	dm	NOUN
biomedich-731	16	40	)	)	PUNCT
biomedich-731	16	41	is	be	AUX
biomedich-731	16	42	the	the	DET
biomedich-731	16	43	enzyme	enzyme	NOUN
biomedich-731	16	44	dipeptidyl	dipeptidyl	NOUN
biomedich-731	16	45	peptidase-4	peptidase-4	X
biomedich-731	16	46	(	(	PUNCT
biomedich-731	16	47	dpp4	dpp4	PROPN
biomedich-731	16	48	)	)	PUNCT
biomedich-731	16	49	,	,	PUNCT
biomedich-731	16	50	which	which	PRON
biomedich-731	16	51	is	be	AUX
biomedich-731	16	52	responsible	responsible	ADJ
biomedich-731	16	53	for	for	ADP
biomedich-731	16	54	degrading	degrade	VERB
biomedich-731	16	55	incretin	incretin	ADJ
biomedich-731	16	56	hormones	hormone	NOUN
biomedich-731	16	57	such	such	ADJ
biomedich-731	16	58	as	as	ADP
biomedich-731	16	59	glucagon	glucagon	NOUN
biomedich-731	16	60	-	-	PUNCT
biomedich-731	16	61	like	like	ADJ
biomedich-731	16	62	peptide-1	peptide-1	PROPN
biomedich-731	16	63	(	(	PUNCT
biomedich-731	16	64	glp-1	glp-1	X
biomedich-731	16	65	)	)	PUNCT
biomedich-731	16	66	and	and	CCONJ
biomedich-731	16	67	glucose	glucose	NOUN
biomedich-731	16	68	-	-	PUNCT
biomedich-731	16	69	dependent	dependent	ADJ
biomedich-731	16	70	insulinotropic	insulinotropic	NOUN
biomedich-731	16	71	polypeptide	polypeptide	ADJ
biomedich-731	16	72	(	(	PUNCT
biomedich-731	16	73	gip	gip	NOUN
biomedich-731	16	74	)	)	PUNCT
biomedich-731	16	75	.	.	PUNCT
biomedich-731	17	1	these	these	DET
biomedich-731	17	2	hormones	hormone	NOUN
biomedich-731	17	3	stimulate	stimulate	VERB
biomedich-731	17	4	insulin	insulin	NOUN
biomedich-731	17	5	secretion	secretion	NOUN
biomedich-731	17	6	in	in	ADP
biomedich-731	17	7	response	response	NOUN
biomedich-731	17	8	to	to	ADP
biomedich-731	17	9	glucose	glucose	NOUN
biomedich-731	17	10	intake	intake	NOUN
biomedich-731	17	11	.	.	PUNCT
biomedich-731	18	1	synthetic	synthetic	ADJ
biomedich-731	18	2	dpp4	dpp4	PROPN
biomedich-731	18	3	inhibitors	inhibitor	NOUN
biomedich-731	18	4	have	have	AUX
biomedich-731	18	5	been	be	AUX
biomedich-731	18	6	widely	widely	ADV
biomedich-731	18	7	used	use	VERB
biomedich-731	18	8	to	to	PART
biomedich-731	18	9	enhance	enhance	VERB
biomedich-731	18	10	incretin	incretin	ADJ
biomedich-731	18	11	levels	level	NOUN
biomedich-731	18	12	,	,	PUNCT
biomedich-731	18	13	improve	improve	VERB
biomedich-731	18	14	glycemic	glycemic	ADJ
biomedich-731	18	15	control	control	NOUN
biomedich-731	18	16	,	,	PUNCT
biomedich-731	18	17	and	and	CCONJ
biomedich-731	18	18	minimize	minimize	VERB
biomedich-731	18	19	the	the	DET
biomedich-731	18	20	risk	risk	NOUN
biomedich-731	18	21	of	of	ADP
biomedich-731	18	22	hypoglycemia	hypoglycemia	NOUN
biomedich-731	18	23	.	.	PUNCT
biomedich-731	19	1	however	however	ADV
biomedich-731	19	2	,	,	PUNCT
biomedich-731	19	3	synthetic	synthetic	ADJ
biomedich-731	19	4	dpp4	dpp4	NOUN
biomedich-731	19	5	inhibitors	inhibitor	NOUN
biomedich-731	19	6	,	,	PUNCT
biomedich-731	19	7	such	such	ADJ
biomedich-731	19	8	as	as	ADP
biomedich-731	19	9	alogliptin	alogliptin	NOUN
biomedich-731	19	10	,	,	PUNCT
biomedich-731	19	11	linagliptin	linagliptin	ADJ
biomedich-731	19	12	,	,	PUNCT
biomedich-731	19	13	saxagliptin	saxagliptin	NOUN
biomedich-731	19	14	,	,	PUNCT
biomedich-731	19	15	sitagliptin	sitagliptin	NOUN
biomedich-731	19	16	,	,	PUNCT
biomedich-731	19	17	and	and	CCONJ
biomedich-731	19	18	vildagliptin	vildagliptin	NOUN
biomedich-731	19	19	,	,	PUNCT
biomedich-731	19	20	are	be	AUX
biomedich-731	19	21	often	often	ADV
biomedich-731	19	22	associated	associate	VERB
biomedich-731	19	23	with	with	ADP
biomedich-731	19	24	side	side	NOUN
biomedich-731	19	25	effects	effect	NOUN
biomedich-731	19	26	,	,	PUNCT
biomedich-731	19	27	including	include	VERB
biomedich-731	19	28	gastrointestinal	gastrointestinal	ADJ
biomedich-731	19	29	disturbances	disturbance	NOUN
biomedich-731	19	30	,	,	PUNCT
biomedich-731	19	31	joint	joint	ADJ
biomedich-731	19	32	pain	pain	NOUN
biomedich-731	19	33	,	,	PUNCT
biomedich-731	19	34	and	and	CCONJ
biomedich-731	19	35	an	an	DET
biomedich-731	19	36	increased	increase	VERB
biomedich-731	19	37	risk	risk	NOUN
biomedich-731	19	38	of	of	ADP
biomedich-731	19	39	respiratory	respiratory	ADJ
biomedich-731	19	40	infections	infection	NOUN
biomedich-731	19	41	(	(	PUNCT
biomedich-731	19	42	azriful	azriful	PROPN
biomedich-731	19	43	et	et	PROPN
biomedich-731	19	44	al	al	PROPN
biomedich-731	19	45	.	.	PROPN
biomedich-731	19	46	,	,	PUNCT
biomedich-731	19	47	2018	2018	NUM
biomedich-731	19	48	)	)	PUNCT
biomedich-731	19	49	.	.	PUNCT
biomedich-731	20	1	the	the	DET
biomedich-731	20	2	introduction	introduction	NOUN
biomedich-731	20	3	of	of	ADP
biomedich-731	20	4	an	an	DET
biomedich-731	20	5	in	in	ADP
biomedich-731	20	6	silico	silico	NOUN
biomedich-731	20	7	analysis	analysis	NOUN
biomedich-731	20	8	of	of	ADP
biomedich-731	20	9	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	20	10	as	as	ADP
biomedich-731	20	11	a	a	DET
biomedich-731	20	12	natural	natural	ADJ
biomedich-731	20	13	antidiabetic	antidiabetic	ADJ
biomedich-731	20	14	agent	agent	NOUN
biomedich-731	20	15	focusing	focus	VERB
biomedich-731	20	16	on	on	ADP
biomedich-731	20	17	its	its	PRON
biomedich-731	20	18	interaction	interaction	NOUN
biomedich-731	20	19	with	with	ADP
biomedich-731	20	20	angiotensin	angiotensin	NOUN
biomedich-731	20	21	-	-	PUNCT
biomedich-731	20	22	converting	convert	VERB
biomedich-731	20	23	enzyme	enzyme	NOUN
biomedich-731	20	24	type	type	NOUN
biomedich-731	20	25	2	2	NUM
biomedich-731	20	26	(	(	PUNCT
biomedich-731	20	27	dpp-4	dpp-4	NUM
biomedich-731	20	28	)	)	PUNCT
biomedich-731	20	29	and	and	CCONJ
biomedich-731	20	30	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	20	31	evaluation	evaluation	NOUN
biomedich-731	20	32	serves	serve	VERB
biomedich-731	20	33	to	to	PART
biomedich-731	20	34	highlight	highlight	VERB
biomedich-731	20	35	the	the	DET
biomedich-731	20	36	compound	compound	NOUN
biomedich-731	20	37	’s	’s	PART
biomedich-731	20	38	potential	potential	ADJ
biomedich-731	20	39	therapeutic	therapeutic	ADJ
biomedich-731	20	40	value	value	NOUN
biomedich-731	20	41	.	.	PUNCT
biomedich-731	21	1	diabetes	diabetes	NOUN
biomedich-731	21	2	mellitus	mellitus	PROPN
biomedich-731	21	3	,	,	PUNCT
biomedich-731	21	4	a	a	DET
biomedich-731	21	5	metabolic	metabolic	NOUN
biomedich-731	21	6	disorder	disorder	NOUN
biomedich-731	21	7	marked	mark	VERB
biomedich-731	21	8	by	by	ADP
biomedich-731	21	9	elevated	elevated	ADJ
biomedich-731	21	10	blood	blood	NOUN
biomedich-731	21	11	glucose	glucose	NOUN
biomedich-731	21	12	levels	level	NOUN
biomedich-731	21	13	,	,	PUNCT
biomedich-731	21	14	is	be	AUX
biomedich-731	21	15	increasingly	increasingly	ADV
biomedich-731	21	16	prevalent	prevalent	ADJ
biomedich-731	21	17	worldwide	worldwide	ADV
biomedich-731	21	18	and	and	CCONJ
biomedich-731	21	19	poses	pose	VERB
biomedich-731	21	20	significant	significant	ADJ
biomedich-731	21	21	public	public	ADJ
biomedich-731	21	22	health	health	NOUN
biomedich-731	21	23	challenges	challenge	NOUN
biomedich-731	21	24	.	.	PUNCT
biomedich-731	22	1	one	one	NUM
biomedich-731	22	2	of	of	ADP
biomedich-731	22	3	the	the	DET
biomedich-731	22	4	key	key	ADJ
biomedich-731	22	5	targets	target	NOUN
biomedich-731	22	6	in	in	ADP
biomedich-731	22	7	the	the	DET
biomedich-731	22	8	management	management	NOUN
biomedich-731	22	9	of	of	ADP
biomedich-731	22	10	diabetes	diabetes	NOUN
biomedich-731	22	11	is	be	AUX
biomedich-731	22	12	the	the	DET
biomedich-731	22	13	dpp-4	dpp-4	ADJ
biomedich-731	22	14	enzyme	enzyme	NOUN
biomedich-731	22	15	,	,	PUNCT
biomedich-731	22	16	which	which	PRON
biomedich-731	22	17	plays	play	VERB
biomedich-731	22	18	a	a	DET
biomedich-731	22	19	pivotal	pivotal	ADJ
biomedich-731	22	20	role	role	NOUN
biomedich-731	22	21	in	in	ADP
biomedich-731	22	22	regulating	regulate	VERB
biomedich-731	22	23	insulin	insulin	NOUN
biomedich-731	22	24	secretion	secretion	NOUN
biomedich-731	22	25	and	and	CCONJ
biomedich-731	22	26	glucose	glucose	NOUN
biomedich-731	22	27	metabolism	metabolism	NOUN
biomedich-731	22	28	.	.	PUNCT
biomedich-731	23	1	inhibiting	inhibit	VERB
biomedich-731	23	2	dpp-4	dpp-4	PRON
biomedich-731	23	3	has	have	AUX
biomedich-731	23	4	emerged	emerge	VERB
biomedich-731	23	5	as	as	ADP
biomedich-731	23	6	a	a	DET
biomedich-731	23	7	promising	promising	ADJ
biomedich-731	23	8	therapeutic	therapeutic	ADJ
biomedich-731	23	9	approach	approach	NOUN
biomedich-731	23	10	for	for	ADP
biomedich-731	23	11	controlling	control	VERB
biomedich-731	23	12	blood	blood	NOUN
biomedich-731	23	13	glucose	glucose	NOUN
biomedich-731	23	14	levels	level	NOUN
biomedich-731	23	15	in	in	ADP
biomedich-731	23	16	diabetic	diabetic	ADJ
biomedich-731	23	17	patients	patient	NOUN
biomedich-731	23	18	.	.	PUNCT
biomedich-731	24	1	4	4	NUM
biomedich-731	24	2	-	-	NUM
biomedich-731	24	3	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	24	4	,	,	PUNCT
biomedich-731	24	5	a	a	DET
biomedich-731	24	6	naturally	naturally	ADV
biomedich-731	24	7	occurring	occur	VERB
biomedich-731	24	8	amino	amino	NOUN
biomedich-731	24	9	acid	acid	PROPN
biomedich-731	24	10	derivative	derivative	NOUN
biomedich-731	24	11	primarily	primarily	ADV
biomedich-731	24	12	found	find	VERB
biomedich-731	24	13	in	in	ADP
biomedich-731	24	14	fenugreek	fenugreek	NOUN
biomedich-731	24	15	seeds	seed	NOUN
biomedich-731	24	16	,	,	PUNCT
biomedich-731	24	17	has	have	AUX
biomedich-731	24	18	been	be	AUX
biomedich-731	24	19	shown	show	VERB
biomedich-731	24	20	to	to	PART
biomedich-731	24	21	possess	possess	VERB
biomedich-731	24	22	antidiabetic	antidiabetic	ADJ
biomedich-731	24	23	properties	property	NOUN
biomedich-731	24	24	through	through	ADP
biomedich-731	24	25	its	its	PRON
biomedich-731	24	26	effects	effect	NOUN
biomedich-731	24	27	on	on	ADP
biomedich-731	24	28	glucose	glucose	NOUN
biomedich-731	24	29	metabolism	metabolism	NOUN
biomedich-731	24	30	.	.	PUNCT
biomedich-731	25	1	this	this	DET
biomedich-731	25	2	study	study	NOUN
biomedich-731	25	3	aims	aim	VERB
biomedich-731	25	4	to	to	PART
biomedich-731	25	5	explore	explore	VERB
biomedich-731	25	6	the	the	PRON
biomedich-731	25	7	in	in	ADP
biomedich-731	25	8	silico	silico	NOUN
biomedich-731	25	9	interaction	interaction	NOUN
biomedich-731	25	10	of	of	ADP
biomedich-731	25	11	4	4	NUM
biomedich-731	25	12	-	-	PUNCT
biomedich-731	25	13	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	25	14	with	with	ADP
biomedich-731	25	15	dpp-4	dpp-4	X
biomedich-731	25	16	,	,	PUNCT
biomedich-731	25	17	a	a	DET
biomedich-731	25	18	critical	critical	ADJ
biomedich-731	25	19	enzyme	enzyme	NOUN
biomedich-731	25	20	involved	involve	VERB
biomedich-731	25	21	in	in	ADP
biomedich-731	25	22	glucose	glucose	NOUN
biomedich-731	25	23	homeostasis	homeostasis	NOUN
biomedich-731	25	24	.	.	PUNCT
biomedich-731	26	1	by	by	ADP
biomedich-731	26	2	utilizing	utilize	VERB
biomedich-731	26	3	advanced	advanced	ADJ
biomedich-731	26	4	computational	computational	ADJ
biomedich-731	26	5	tools	tool	NOUN
biomedich-731	26	6	and	and	CCONJ
biomedich-731	26	7	molecular	molecular	ADJ
biomedich-731	26	8	docking	docking	NOUN
biomedich-731	26	9	techniques	technique	NOUN
biomedich-731	26	10	,	,	PUNCT
biomedich-731	26	11	we	we	PRON
biomedich-731	26	12	aim	aim	VERB
biomedich-731	26	13	to	to	PART
biomedich-731	26	14	assess	assess	VERB
biomedich-731	26	15	how	how	SCONJ
biomedich-731	26	16	4	4	NUM
biomedich-731	26	17	-	-	PUNCT
biomedich-731	26	18	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	26	19	binds	bind	VERB
biomedich-731	26	20	to	to	ADP
biomedich-731	26	21	the	the	DET
biomedich-731	26	22	dpp-4	dpp-4	ADJ
biomedich-731	26	23	receptor	receptor	NOUN
biomedich-731	26	24	,	,	PUNCT
biomedich-731	26	25	potentially	potentially	ADV
biomedich-731	26	26	inhibiting	inhibit	VERB
biomedich-731	26	27	its	its	PRON
biomedich-731	26	28	activity	activity	NOUN
biomedich-731	26	29	and	and	CCONJ
biomedich-731	26	30	contributing	contribute	VERB
biomedich-731	26	31	to	to	ADP
biomedich-731	26	32	better	well	ADJ
biomedich-731	26	33	glycemic	glycemic	ADJ
biomedich-731	26	34	control	control	NOUN
biomedich-731	26	35	.	.	PUNCT
biomedich-731	27	1	additionally	additionally	ADV
biomedich-731	27	2	,	,	PUNCT
biomedich-731	27	3	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	27	4	evaluations	evaluation	NOUN
biomedich-731	27	5	are	be	AUX
biomedich-731	27	6	integral	integral	ADJ
biomedich-731	27	7	to	to	ADP
biomedich-731	27	8	understanding	understand	VERB
biomedich-731	27	9	the	the	DET
biomedich-731	27	10	compound	compound	NOUN
biomedich-731	27	11	's	's	PART
biomedich-731	27	12	bioavailability	bioavailability	NOUN
biomedich-731	27	13	,	,	PUNCT
biomedich-731	27	14	absorption	absorption	NOUN
biomedich-731	27	15	,	,	PUNCT
biomedich-731	27	16	distribution	distribution	NOUN
biomedich-731	27	17	,	,	PUNCT
biomedich-731	27	18	metabolism	metabolism	NOUN
biomedich-731	27	19	,	,	PUNCT
biomedich-731	27	20	and	and	CCONJ
biomedich-731	27	21	excretion	excretion	NOUN
biomedich-731	27	22	(	(	PUNCT
biomedich-731	27	23	adme	adme	NOUN
biomedich-731	27	24	)	)	PUNCT
biomedich-731	27	25	properties	property	NOUN
biomedich-731	27	26	.	.	PUNCT
biomedich-731	28	1	this	this	DET
biomedich-731	28	2	aspect	aspect	NOUN
biomedich-731	28	3	is	be	AUX
biomedich-731	28	4	crucial	crucial	ADJ
biomedich-731	28	5	to	to	PART
biomedich-731	28	6	determine	determine	VERB
biomedich-731	28	7	the	the	DET
biomedich-731	28	8	compound	compound	NOUN
biomedich-731	28	9	's	's	PART
biomedich-731	28	10	potential	potential	NOUN
biomedich-731	28	11	for	for	ADP
biomedich-731	28	12	effective	effective	ADJ
biomedich-731	28	13	oral	oral	ADJ
biomedich-731	28	14	administration	administration	NOUN
biomedich-731	28	15	and	and	CCONJ
biomedich-731	28	16	safety	safety	NOUN
biomedich-731	28	17	profile	profile	NOUN
biomedich-731	28	18	(	(	PUNCT
biomedich-731	28	19	anitha	anitha	NOUN
biomedich-731	28	20	et	et	PROPN
biomedich-731	28	21	al	al	PROPN
biomedich-731	28	22	,	,	PUNCT
biomedich-731	28	23	2013	2013	NUM
biomedich-731	28	24	)	)	PUNCT
biomedich-731	28	25	.	.	PUNCT
biomedich-731	29	1	swissadme	swissadme	NOUN
biomedich-731	29	2	and	and	CCONJ
biomedich-731	29	3	other	other	ADJ
biomedich-731	29	4	computational	computational	ADJ
biomedich-731	29	5	platforms	platform	NOUN
biomedich-731	29	6	predict	predict	VERB
biomedich-731	29	7	the	the	DET
biomedich-731	29	8	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	29	9	properties	property	NOUN
biomedich-731	29	10	of	of	ADP
biomedich-731	29	11	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	29	12	,	,	PUNCT
biomedich-731	29	13	providing	provide	VERB
biomedich-731	29	14	insights	insight	NOUN
biomedich-731	29	15	into	into	ADP
biomedich-731	29	16	its	its	PRON
biomedich-731	29	17	solubility	solubility	NOUN
biomedich-731	29	18	,	,	PUNCT
biomedich-731	29	19	permeability	permeability	NOUN
biomedich-731	29	20	,	,	PUNCT
biomedich-731	29	21	and	and	CCONJ
biomedich-731	29	22	potential	potential	ADJ
biomedich-731	29	23	toxicity	toxicity	NOUN
biomedich-731	29	24	.	.	PUNCT
biomedich-731	30	1	in	in	ADP
biomedich-731	30	2	summary	summary	NOUN
biomedich-731	30	3	,	,	PUNCT
biomedich-731	30	4	this	this	DET
biomedich-731	30	5	study	study	NOUN
biomedich-731	30	6	explores	explore	VERB
biomedich-731	30	7	4	4	NUM
biomedich-731	30	8	-	-	PUNCT
biomedich-731	30	9	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	30	10	’s	’s	PART
biomedich-731	30	11	dual	dual	ADJ
biomedich-731	30	12	role	role	NOUN
biomedich-731	30	13	as	as	ADP
biomedich-731	30	14	a	a	DET
biomedich-731	30	15	natural	natural	ADJ
biomedich-731	30	16	dpp-4	dpp-4	ADJ
biomedich-731	30	17	inhibitor	inhibitor	NOUN
biomedich-731	30	18	and	and	CCONJ
biomedich-731	30	19	evaluates	evaluate	VERB
biomedich-731	30	20	its	its	PRON
biomedich-731	30	21	https://doi.org/10.14421/biomedich.2025.141.409-415	https://doi.org/10.14421/biomedich.2025.141.409-415	NOUN
biomedich-731	30	22	410	410	NUM
biomedich-731	30	23	biology	biology	NOUN
biomedich-731	30	24	,	,	PUNCT
biomedich-731	30	25	medicine	medicine	NOUN
biomedich-731	30	26	,	,	PUNCT
biomedich-731	30	27	&	&	CCONJ
biomedich-731	30	28	natural	natural	ADJ
biomedich-731	30	29	product	product	NOUN
biomedich-731	30	30	chemistry	chemistry	NOUN
biomedich-731	30	31	14	14	NUM
biomedich-731	30	32	(	(	PUNCT
biomedich-731	30	33	1	1	NUM
biomedich-731	30	34	)	)	PUNCT
biomedich-731	30	35	,	,	PUNCT
biomedich-731	30	36	2025	2025	NUM
biomedich-731	30	37	:	:	PUNCT
biomedich-731	30	38	409	409	NUM
biomedich-731	30	39	-	-	SYM
biomedich-731	30	40	415	415	NUM
biomedich-731	30	41	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	30	42	characteristics	characteristic	NOUN
biomedich-731	30	43	to	to	PART
biomedich-731	30	44	establish	establish	VERB
biomedich-731	30	45	its	its	PRON
biomedich-731	30	46	viability	viability	NOUN
biomedich-731	30	47	as	as	ADP
biomedich-731	30	48	a	a	DET
biomedich-731	30	49	potential	potential	ADJ
biomedich-731	30	50	therapeutic	therapeutic	ADJ
biomedich-731	30	51	agent	agent	NOUN
biomedich-731	30	52	for	for	ADP
biomedich-731	30	53	diabetes	diabetes	NOUN
biomedich-731	30	54	management	management	NOUN
biomedich-731	30	55	.	.	PUNCT
biomedich-731	31	1	the	the	DET
biomedich-731	31	2	findings	finding	NOUN
biomedich-731	31	3	could	could	AUX
biomedich-731	31	4	pave	pave	VERB
biomedich-731	31	5	the	the	DET
biomedich-731	31	6	way	way	NOUN
biomedich-731	31	7	for	for	ADP
biomedich-731	31	8	further	further	ADJ
biomedich-731	31	9	research	research	NOUN
biomedich-731	31	10	and	and	CCONJ
biomedich-731	31	11	development	development	NOUN
biomedich-731	31	12	of	of	ADP
biomedich-731	31	13	4	4	NUM
biomedich-731	31	14	-	-	PUNCT
biomedich-731	31	15	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	31	16	-	-	PUNCT
biomedich-731	31	17	based	base	VERB
biomedich-731	31	18	formulations	formulation	NOUN
biomedich-731	31	19	in	in	ADP
biomedich-731	31	20	treating	treat	VERB
biomedich-731	31	21	diabetes	diabetes	NOUN
biomedich-731	31	22	,	,	PUNCT
biomedich-731	31	23	offering	offer	VERB
biomedich-731	31	24	a	a	DET
biomedich-731	31	25	promising	promising	ADJ
biomedich-731	31	26	natural	natural	ADJ
biomedich-731	31	27	alternative	alternative	NOUN
biomedich-731	31	28	to	to	ADP
biomedich-731	31	29	synthetic	synthetic	ADJ
biomedich-731	31	30	drugs	drug	NOUN
biomedich-731	31	31	(	(	PUNCT
biomedich-731	31	32	itoh	itoh	X
biomedich-731	31	33	et	et	PROPN
biomedich-731	31	34	al	al	PROPN
biomedich-731	31	35	,	,	PUNCT
biomedich-731	31	36	2019	2019	NUM
biomedich-731	31	37	)	)	PUNCT
biomedich-731	31	38	.	.	PUNCT
biomedich-731	32	1	materials	material	NOUN
biomedich-731	32	2	and	and	CCONJ
biomedich-731	32	3	methods	method	NOUN
biomedich-731	32	4	study	study	NOUN
biomedich-731	32	5	area	area	NOUN
biomedich-731	32	6	for	for	ADP
biomedich-731	32	7	molecular	molecular	ADJ
biomedich-731	32	8	docking	docking	NOUN
biomedich-731	32	9	process	process	NOUN
biomedich-731	32	10	,	,	PUNCT
biomedich-731	32	11	this	this	DET
biomedich-731	32	12	study	study	NOUN
biomedich-731	32	13	used	use	VERB
biomedich-731	32	14	a	a	DET
biomedich-731	32	15	computer	computer	NOUN
biomedich-731	32	16	with	with	ADP
biomedich-731	32	17	specifications	specification	NOUN
biomedich-731	32	18	:	:	PUNCT
biomedich-731	32	19	intel(r	intel(r	NOUN
biomedich-731	32	20	)	)	PUNCT
biomedich-731	32	21	celeron(r	celeron(r	NOUN
biomedich-731	32	22	)	)	PUNCT
biomedich-731	32	23	n4020	n4020	PRON
biomedich-731	32	24	cpu	cpu	VERB
biomedich-731	32	25	@	@	ADP
biomedich-731	32	26	1.10ghz	1.10ghz	NUM
biomedich-731	32	27	,	,	PUNCT
biomedich-731	32	28	1101	1101	NUM
biomedich-731	32	29	mhz	mhz	NOUN
biomedich-731	32	30	,	,	PUNCT
biomedich-731	32	31	2	2	NUM
biomedich-731	32	32	core(s	core(s	NOUN
biomedich-731	32	33	)	)	PUNCT
biomedich-731	32	34	,	,	PUNCT
biomedich-731	32	35	2	2	NUM
biomedich-731	32	36	logical	logical	ADJ
biomedich-731	32	37	processor(s	processor(s	NOUN
biomedich-731	32	38	)	)	PUNCT
biomedich-731	32	39	,	,	PUNCT
biomedich-731	32	40	4	4	NUM
biomedich-731	32	41	gb	gb	NOUN
biomedich-731	32	42	ram	ram	NOUN
biomedich-731	32	43	,	,	PUNCT
biomedich-731	32	44	and	and	CCONJ
biomedich-731	32	45	operating	operating	NOUN
biomedich-731	32	46	system	system	NOUN
biomedich-731	32	47	:	:	PUNCT
biomedich-731	32	48	microsoft	microsoft	PROPN
biomedich-731	32	49	windows	window	VERB
biomedich-731	32	50	11	11	NUM
biomedich-731	32	51	home	home	NOUN
biomedich-731	32	52	single	single	ADJ
biomedich-731	32	53	language	language	NOUN
biomedich-731	32	54	(	(	PUNCT
biomedich-731	32	55	10.0.22631	10.0.22631	PROPN
biomedich-731	32	56	build	build	VERB
biomedich-731	32	57	22631	22631	NUM
biomedich-731	32	58	)	)	PUNCT
biomedich-731	32	59	bios	bio	NOUN
biomedich-731	32	60	:	:	PUNCT
biomedich-731	32	61	dvcn17ww	dvcn17ww	VERB
biomedich-731	32	62	procedures	procedure	NOUN
biomedich-731	32	63	preparation	preparation	NOUN
biomedich-731	32	64	and	and	CCONJ
biomedich-731	32	65	ligands	ligand	VERB
biomedich-731	32	66	the	the	DET
biomedich-731	32	67	primary	primary	ADJ
biomedich-731	32	68	compound	compound	NOUN
biomedich-731	32	69	analyzed	analyze	VERB
biomedich-731	32	70	in	in	ADP
biomedich-731	32	71	this	this	DET
biomedich-731	32	72	study	study	NOUN
biomedich-731	32	73	was	be	AUX
biomedich-731	32	74	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	32	75	,	,	PUNCT
biomedich-731	32	76	a	a	DET
biomedich-731	32	77	natural	natural	ADJ
biomedich-731	32	78	glycoside	glycoside	NOUN
biomedich-731	32	79	derived	derive	VERB
biomedich-731	32	80	from	from	ADP
biomedich-731	32	81	fava	fava	NOUN
biomedich-731	32	82	beans	bean	NOUN
biomedich-731	32	83	(	(	PUNCT
biomedich-731	32	84	vicia	vicia	PROPN
biomedich-731	32	85	faba	faba	NOUN
biomedich-731	32	86	)	)	PUNCT
biomedich-731	32	87	.	.	PUNCT
biomedich-731	33	1	the	the	DET
biomedich-731	33	2	2d	2d	PROPN
biomedich-731	33	3	and	and	CCONJ
biomedich-731	33	4	3d	3d	NUM
biomedich-731	33	5	structures	structure	NOUN
biomedich-731	33	6	of	of	ADP
biomedich-731	33	7	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	33	8	were	be	AUX
biomedich-731	33	9	obtained	obtain	VERB
biomedich-731	33	10	from	from	ADP
biomedich-731	33	11	the	the	DET
biomedich-731	33	12	pubchem	pubchem	NOUN
biomedich-731	33	13	database	database	NOUN
biomedich-731	33	14	(	(	PUNCT
biomedich-731	33	15	cid	cid	NOUN
biomedich-731	33	16	:	:	PUNCT
biomedich-731	33	17	xxxx	xxxx	ADJ
biomedich-731	33	18	)	)	PUNCT
biomedich-731	33	19	in	in	ADP
biomedich-731	33	20	sdf	sdf	PROPN
biomedich-731	33	21	format	format	NOUN
biomedich-731	33	22	.	.	PUNCT
biomedich-731	34	1	the	the	DET
biomedich-731	34	2	target	target	NOUN
biomedich-731	34	3	protein	protein	NOUN
biomedich-731	34	4	,	,	PUNCT
biomedich-731	34	5	dipeptidyl	dipeptidyl	ADJ
biomedich-731	34	6	peptidase-4	peptidase-4	X
biomedich-731	34	7	(	(	PUNCT
biomedich-731	34	8	dpp4	dpp4	PROPN
biomedich-731	34	9	)	)	PUNCT
biomedich-731	34	10	,	,	PUNCT
biomedich-731	34	11	was	be	AUX
biomedich-731	34	12	retrieved	retrieve	VERB
biomedich-731	34	13	from	from	ADP
biomedich-731	34	14	the	the	DET
biomedich-731	34	15	protein	protein	NOUN
biomedich-731	34	16	data	datum	NOUN
biomedich-731	34	17	bank	bank	PROPN
biomedich-731	34	18	(	(	PUNCT
biomedich-731	34	19	pdb	pdb	PROPN
biomedich-731	34	20	i	i	PROPN
biomedich-731	34	21	d	d	PROPN
biomedich-731	34	22	:	:	PUNCT
biomedich-731	34	23	xxxx	xxxx	ADJ
biomedich-731	34	24	)	)	PUNCT
biomedich-731	34	25	in	in	ADP
biomedich-731	34	26	pdb	pdb	PROPN
biomedich-731	34	27	format	format	NOUN
biomedich-731	34	28	.	.	PUNCT
biomedich-731	35	1	the	the	DET
biomedich-731	35	2	protein	protein	NOUN
biomedich-731	35	3	and	and	CCONJ
biomedich-731	35	4	ligand	ligand	NOUN
biomedich-731	35	5	structures	structure	NOUN
biomedich-731	35	6	were	be	AUX
biomedich-731	35	7	prepared	prepare	VERB
biomedich-731	35	8	using	use	VERB
biomedich-731	35	9	pymol	pymol	NOUN
biomedich-731	35	10	software	software	NOUN
biomedich-731	35	11	(	(	PUNCT
biomedich-731	35	12	made	make	VERB
biomedich-731	35	13	&	&	CCONJ
biomedich-731	35	14	pathni	pathni	PROPN
biomedich-731	35	15	,	,	PUNCT
biomedich-731	35	16	2018	2018	NUM
biomedich-731	35	17	)	)	PUNCT
biomedich-731	35	18	.	.	PUNCT
biomedich-731	36	1	water	water	NOUN
biomedich-731	36	2	molecules	molecule	NOUN
biomedich-731	36	3	were	be	AUX
biomedich-731	36	4	removed	remove	VERB
biomedich-731	36	5	from	from	ADP
biomedich-731	36	6	the	the	DET
biomedich-731	36	7	protein	protein	NOUN
biomedich-731	36	8	structure	structure	NOUN
biomedich-731	36	9	to	to	PART
biomedich-731	36	10	ensure	ensure	VERB
biomedich-731	36	11	accurate	accurate	ADJ
biomedich-731	36	12	molecular	molecular	ADJ
biomedich-731	36	13	docking	docking	NOUN
biomedich-731	36	14	,	,	PUNCT
biomedich-731	36	15	while	while	SCONJ
biomedich-731	36	16	polar	polar	ADJ
biomedich-731	36	17	hydrogens	hydrogen	NOUN
biomedich-731	36	18	and	and	CCONJ
biomedich-731	36	19	kollman	kollman	NOUN
biomedich-731	36	20	charges	charge	NOUN
biomedich-731	36	21	were	be	AUX
biomedich-731	36	22	added	add	VERB
biomedich-731	36	23	to	to	PART
biomedich-731	36	24	stabilize	stabilize	VERB
biomedich-731	36	25	the	the	DET
biomedich-731	36	26	protein	protein	NOUN
biomedich-731	36	27	-	-	PUNCT
biomedich-731	36	28	ligand	ligand	NOUN
biomedich-731	36	29	interaction	interaction	NOUN
biomedich-731	36	30	(	(	PUNCT
biomedich-731	36	31	nayeem	nayeem	VERB
biomedich-731	36	32	et	et	PROPN
biomedich-731	36	33	al	al	PROPN
biomedich-731	36	34	.	.	PROPN
biomedich-731	36	35	,	,	PUNCT
biomedich-731	36	36	2021	2021	NUM
biomedich-731	36	37	)	)	PUNCT
biomedich-731	36	38	.	.	PUNCT
biomedich-731	37	1	the	the	DET
biomedich-731	37	2	ligand	ligand	ADJ
biomedich-731	37	3	structure	structure	NOUN
biomedich-731	37	4	was	be	AUX
biomedich-731	37	5	optimized	optimize	VERB
biomedich-731	37	6	for	for	ADP
biomedich-731	37	7	energy	energy	NOUN
biomedich-731	37	8	minimization	minimization	NOUN
biomedich-731	37	9	using	use	VERB
biomedich-731	37	10	open	open	ADJ
biomedich-731	37	11	babel	babel	NOUN
biomedich-731	37	12	within	within	ADP
biomedich-731	37	13	pyrx	pyrx	NOUN
biomedich-731	37	14	software	software	NOUN
biomedich-731	37	15	to	to	PART
biomedich-731	37	16	eliminate	eliminate	VERB
biomedich-731	37	17	steric	steric	ADJ
biomedich-731	37	18	clashes	clash	NOUN
biomedich-731	37	19	and	and	CCONJ
biomedich-731	37	20	maintain	maintain	VERB
biomedich-731	37	21	proper	proper	ADJ
biomedich-731	37	22	molecular	molecular	ADJ
biomedich-731	37	23	geometry	geometry	NOUN
biomedich-731	37	24	.	.	PUNCT
biomedich-731	38	1	the	the	DET
biomedich-731	38	2	prepared	prepare	VERB
biomedich-731	38	3	protein	protein	NOUN
biomedich-731	38	4	and	and	CCONJ
biomedich-731	38	5	ligand	ligand	ADJ
biomedich-731	38	6	files	file	NOUN
biomedich-731	38	7	were	be	AUX
biomedich-731	38	8	saved	save	VERB
biomedich-731	38	9	in	in	ADP
biomedich-731	38	10	pdbqt	pdbqt	ADJ
biomedich-731	38	11	format	format	NOUN
biomedich-731	38	12	,	,	PUNCT
biomedich-731	38	13	making	make	VERB
biomedich-731	38	14	them	they	PRON
biomedich-731	38	15	compatible	compatible	ADJ
biomedich-731	38	16	with	with	ADP
biomedich-731	38	17	autodock	autodock	PROPN
biomedich-731	38	18	vina	vina	PROPN
biomedich-731	38	19	.	.	PUNCT
biomedich-731	39	1	these	these	DET
biomedich-731	39	2	prepared	prepared	ADJ
biomedich-731	39	3	structures	structure	NOUN
biomedich-731	39	4	were	be	AUX
biomedich-731	39	5	then	then	ADV
biomedich-731	39	6	used	use	VERB
biomedich-731	39	7	for	for	ADP
biomedich-731	39	8	the	the	DET
biomedich-731	39	9	docking	docking	NOUN
biomedich-731	39	10	process	process	NOUN
biomedich-731	39	11	to	to	PART
biomedich-731	39	12	analyze	analyze	VERB
biomedich-731	39	13	the	the	DET
biomedich-731	39	14	binding	bind	VERB
biomedich-731	39	15	affinity	affinity	NOUN
biomedich-731	39	16	of	of	ADP
biomedich-731	39	17	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	39	18	to	to	ADP
biomedich-731	39	19	dpp4	dpp4	PROPN
biomedich-731	39	20	and	and	CCONJ
biomedich-731	39	21	compare	compare	VERB
biomedich-731	39	22	it	it	PRON
biomedich-731	39	23	to	to	ADP
biomedich-731	39	24	standard	standard	ADJ
biomedich-731	39	25	synthetic	synthetic	ADJ
biomedich-731	39	26	inhibitors	inhibitor	NOUN
biomedich-731	39	27	,	,	PUNCT
biomedich-731	39	28	including	include	VERB
biomedich-731	39	29	alogliptin	alogliptin	NOUN
biomedich-731	39	30	,	,	PUNCT
biomedich-731	39	31	linagliptin	linagliptin	ADJ
biomedich-731	39	32	,	,	PUNCT
biomedich-731	39	33	saxagliptin	saxagliptin	NOUN
biomedich-731	39	34	,	,	PUNCT
biomedich-731	39	35	sitagliptin	sitagliptin	NOUN
biomedich-731	39	36	,	,	PUNCT
biomedich-731	39	37	and	and	CCONJ
biomedich-731	39	38	vildagliptin	vildagliptin	NOUN
biomedich-731	39	39	(	(	PUNCT
biomedich-731	39	40	pantaleão	pantaleão	PROPN
biomedich-731	39	41	et	et	PROPN
biomedich-731	39	42	al	al	PROPN
biomedich-731	39	43	.	.	PROPN
biomedich-731	39	44	,	,	PUNCT
biomedich-731	39	45	2018	2018	NUM
biomedich-731	39	46	)	)	PUNCT
biomedich-731	39	47	.	.	PUNCT
biomedich-731	40	1	protein	protein	NOUN
biomedich-731	40	2	validation	validation	NOUN
biomedich-731	40	3	in	in	ADP
biomedich-731	40	4	an	an	DET
biomedich-731	40	5	silico	silico	NOUN
biomedich-731	40	6	analysis	analysis	NOUN
biomedich-731	40	7	for	for	ADP
biomedich-731	40	8	protein	protein	NOUN
biomedich-731	40	9	validation	validation	NOUN
biomedich-731	40	10	after	after	ADP
biomedich-731	40	11	the	the	DET
biomedich-731	40	12	preparation	preparation	NOUN
biomedich-731	40	13	of	of	ADP
biomedich-731	40	14	the	the	DET
biomedich-731	40	15	protein	protein	NOUN
biomedich-731	40	16	and	and	CCONJ
biomedich-731	40	17	ligand	ligand	ADJ
biomedich-731	40	18	,	,	PUNCT
biomedich-731	40	19	several	several	ADJ
biomedich-731	40	20	steps	step	NOUN
biomedich-731	40	21	are	be	AUX
biomedich-731	40	22	followed	follow	VERB
biomedich-731	40	23	to	to	PART
biomedich-731	40	24	ensure	ensure	VERB
biomedich-731	40	25	that	that	SCONJ
biomedich-731	40	26	the	the	DET
biomedich-731	40	27	obtained	obtain	VERB
biomedich-731	40	28	protein	protein	NOUN
biomedich-731	40	29	structure	structure	NOUN
biomedich-731	40	30	and	and	CCONJ
biomedich-731	40	31	its	its	PRON
biomedich-731	40	32	interaction	interaction	NOUN
biomedich-731	40	33	with	with	ADP
biomedich-731	40	34	the	the	DET
biomedich-731	40	35	ligand	ligand	NOUN
biomedich-731	40	36	are	be	AUX
biomedich-731	40	37	accurate	accurate	ADJ
biomedich-731	40	38	and	and	CCONJ
biomedich-731	40	39	acceptable	acceptable	ADJ
biomedich-731	40	40	for	for	ADP
biomedich-731	40	41	further	further	ADJ
biomedich-731	40	42	studies	study	NOUN
biomedich-731	40	43	.	.	PUNCT
biomedich-731	41	1	initially	initially	ADV
biomedich-731	41	2	,	,	PUNCT
biomedich-731	41	3	after	after	SCONJ
biomedich-731	41	4	the	the	DET
biomedich-731	41	5	protein	protein	NOUN
biomedich-731	41	6	structure	structure	NOUN
biomedich-731	41	7	is	be	AUX
biomedich-731	41	8	prepared	prepare	VERB
biomedich-731	41	9	,	,	PUNCT
biomedich-731	41	10	software	software	NOUN
biomedich-731	41	11	tools	tool	NOUN
biomedich-731	41	12	such	such	ADJ
biomedich-731	41	13	as	as	ADP
biomedich-731	41	14	pymol	pymol	NOUN
biomedich-731	41	15	for	for	ADP
biomedich-731	41	16	visualization	visualization	NOUN
biomedich-731	41	17	and	and	CCONJ
biomedich-731	41	18	structural	structural	ADJ
biomedich-731	41	19	analysis	analysis	NOUN
biomedich-731	41	20	are	be	AUX
biomedich-731	41	21	used	use	VERB
biomedich-731	41	22	.	.	PUNCT
biomedich-731	42	1	this	this	DET
biomedich-731	42	2	visual	visual	ADJ
biomedich-731	42	3	inspection	inspection	NOUN
biomedich-731	42	4	aims	aim	VERB
biomedich-731	42	5	to	to	PART
biomedich-731	42	6	confirm	confirm	VERB
biomedich-731	42	7	no	no	DET
biomedich-731	42	8	visible	visible	ADJ
biomedich-731	42	9	structural	structural	ADJ
biomedich-731	42	10	defects	defect	NOUN
biomedich-731	42	11	,	,	PUNCT
biomedich-731	42	12	such	such	ADJ
biomedich-731	42	13	as	as	ADP
biomedich-731	42	14	irregular	irregular	ADJ
biomedich-731	42	15	loops	loop	NOUN
biomedich-731	42	16	or	or	CCONJ
biomedich-731	42	17	improper	improper	ADJ
biomedich-731	42	18	bindings	binding	NOUN
biomedich-731	42	19	.	.	PUNCT
biomedich-731	43	1	following	follow	VERB
biomedich-731	43	2	this	this	PRON
biomedich-731	43	3	,	,	PUNCT
biomedich-731	43	4	the	the	DET
biomedich-731	43	5	quality	quality	NOUN
biomedich-731	43	6	of	of	ADP
biomedich-731	43	7	the	the	DET
biomedich-731	43	8	prepared	prepared	ADJ
biomedich-731	43	9	protein	protein	NOUN
biomedich-731	43	10	structure	structure	NOUN
biomedich-731	43	11	is	be	AUX
biomedich-731	43	12	assessed	assess	VERB
biomedich-731	43	13	using	use	VERB
biomedich-731	43	14	tools	tool	NOUN
biomedich-731	43	15	like	like	ADP
biomedich-731	43	16	procheck	procheck	NOUN
biomedich-731	43	17	,	,	PUNCT
biomedich-731	43	18	which	which	PRON
biomedich-731	43	19	help	help	AUX
biomedich-731	43	20	verify	verify	VERB
biomedich-731	43	21	the	the	DET
biomedich-731	43	22	validity	validity	NOUN
biomedich-731	43	23	of	of	ADP
biomedich-731	43	24	the	the	DET
biomedich-731	43	25	protein	protein	NOUN
biomedich-731	43	26	structure	structure	NOUN
biomedich-731	43	27	based	base	VERB
biomedich-731	43	28	on	on	ADP
biomedich-731	43	29	geometric	geometric	ADJ
biomedich-731	43	30	statistics	statistic	NOUN
biomedich-731	43	31	and	and	CCONJ
biomedich-731	43	32	the	the	DET
biomedich-731	43	33	distribution	distribution	NOUN
biomedich-731	43	34	of	of	ADP
biomedich-731	43	35	phi	phi	ADJ
biomedich-731	43	36	-	-	PUNCT
biomedich-731	43	37	psi	psi	NOUN
biomedich-731	43	38	angles	angle	NOUN
biomedich-731	43	39	.	.	PUNCT
biomedich-731	44	1	while	while	SCONJ
biomedich-731	44	2	statistical	statistical	ADJ
biomedich-731	44	3	analyses	analysis	NOUN
biomedich-731	44	4	such	such	ADJ
biomedich-731	44	5	as	as	ADP
biomedich-731	44	6	ramachandran	ramachandran	NOUN
biomedich-731	44	7	plots	plot	NOUN
biomedich-731	44	8	are	be	AUX
biomedich-731	44	9	commonly	commonly	ADV
biomedich-731	44	10	used	use	VERB
biomedich-731	44	11	for	for	ADP
biomedich-731	44	12	further	further	ADJ
biomedich-731	44	13	evaluation	evaluation	NOUN
biomedich-731	44	14	,	,	PUNCT
biomedich-731	44	15	the	the	DET
biomedich-731	44	16	focus	focus	NOUN
biomedich-731	44	17	is	be	AUX
biomedich-731	44	18	on	on	ADP
biomedich-731	44	19	ensuring	ensure	VERB
biomedich-731	44	20	the	the	DET
biomedich-731	44	21	protein	protein	NOUN
biomedich-731	44	22	model	model	NOUN
biomedich-731	44	23	used	use	VERB
biomedich-731	44	24	in	in	ADP
biomedich-731	44	25	the	the	DET
biomedich-731	44	26	simulation	simulation	NOUN
biomedich-731	44	27	is	be	AUX
biomedich-731	44	28	reliable	reliable	ADJ
biomedich-731	44	29	.	.	PUNCT
biomedich-731	45	1	additionally	additionally	ADV
biomedich-731	45	2	,	,	PUNCT
biomedich-731	45	3	the	the	DET
biomedich-731	45	4	protein	protein	NOUN
biomedich-731	45	5	structure	structure	NOUN
biomedich-731	45	6	’s	’s	PART
biomedich-731	45	7	interaction	interaction	NOUN
biomedich-731	45	8	energy	energy	NOUN
biomedich-731	45	9	is	be	AUX
biomedich-731	45	10	assessed	assess	VERB
biomedich-731	45	11	to	to	PART
biomedich-731	45	12	ensure	ensure	VERB
biomedich-731	45	13	that	that	SCONJ
biomedich-731	45	14	the	the	DET
biomedich-731	45	15	protein	protein	NOUN
biomedich-731	45	16	is	be	AUX
biomedich-731	45	17	in	in	ADP
biomedich-731	45	18	a	a	DET
biomedich-731	45	19	stable	stable	ADJ
biomedich-731	45	20	state	state	NOUN
biomedich-731	45	21	.	.	PUNCT
biomedich-731	46	1	molecular	molecular	ADJ
biomedich-731	46	2	dynamics	dynamic	NOUN
biomedich-731	46	3	simulations	simulation	NOUN
biomedich-731	46	4	or	or	CCONJ
biomedich-731	46	5	protein	protein	NOUN
biomedich-731	46	6	-	-	PUNCT
biomedich-731	46	7	ligand	ligand	NOUN
biomedich-731	46	8	binding	bind	VERB
biomedich-731	46	9	energy	energy	NOUN
biomedich-731	46	10	predictions	prediction	NOUN
biomedich-731	46	11	using	use	VERB
biomedich-731	46	12	software	software	NOUN
biomedich-731	46	13	like	like	ADP
biomedich-731	46	14	autodock	autodock	NOUN
biomedich-731	46	15	are	be	AUX
biomedich-731	46	16	used	use	VERB
biomedich-731	46	17	to	to	PART
biomedich-731	46	18	verify	verify	VERB
biomedich-731	46	19	that	that	SCONJ
biomedich-731	46	20	the	the	DET
biomedich-731	46	21	interaction	interaction	NOUN
biomedich-731	46	22	with	with	ADP
biomedich-731	46	23	the	the	DET
biomedich-731	46	24	ligand	ligand	NOUN
biomedich-731	46	25	remains	remain	VERB
biomedich-731	46	26	within	within	ADP
biomedich-731	46	27	biologically	biologically	ADV
biomedich-731	46	28	acceptable	acceptable	ADJ
biomedich-731	46	29	parameters	parameter	NOUN
biomedich-731	46	30	.	.	PUNCT
biomedich-731	47	1	the	the	DET
biomedich-731	47	2	protein	protein	NOUN
biomedich-731	47	3	structure	structure	NOUN
biomedich-731	47	4	is	be	AUX
biomedich-731	47	5	then	then	ADV
biomedich-731	47	6	refined	refine	VERB
biomedich-731	47	7	through	through	ADP
biomedich-731	47	8	energy	energy	NOUN
biomedich-731	47	9	optimization	optimization	NOUN
biomedich-731	47	10	procedures	procedure	NOUN
biomedich-731	47	11	,	,	PUNCT
biomedich-731	47	12	where	where	SCONJ
biomedich-731	47	13	atom	atom	NOUN
biomedich-731	47	14	positions	position	NOUN
biomedich-731	47	15	are	be	AUX
biomedich-731	47	16	adjusted	adjust	VERB
biomedich-731	47	17	to	to	PART
biomedich-731	47	18	minimize	minimize	VERB
biomedich-731	47	19	the	the	DET
biomedich-731	47	20	total	total	ADJ
biomedich-731	47	21	energy	energy	NOUN
biomedich-731	47	22	,	,	PUNCT
biomedich-731	47	23	enhancing	enhance	VERB
biomedich-731	47	24	the	the	DET
biomedich-731	47	25	model	model	NOUN
biomedich-731	47	26	’s	’s	PART
biomedich-731	47	27	accuracy	accuracy	NOUN
biomedich-731	47	28	and	and	CCONJ
biomedich-731	47	29	ensuring	ensure	VERB
biomedich-731	47	30	it	it	PRON
biomedich-731	47	31	represents	represent	VERB
biomedich-731	47	32	the	the	DET
biomedich-731	47	33	natural	natural	ADJ
biomedich-731	47	34	protein	protein	NOUN
biomedich-731	47	35	form	form	NOUN
biomedich-731	47	36	more	more	ADV
biomedich-731	47	37	precisely	precisely	ADV
biomedich-731	47	38	(	(	PUNCT
biomedich-731	47	39	samata	samata	X
biomedich-731	47	40	et	et	PROPN
biomedich-731	47	41	al	al	PROPN
biomedich-731	47	42	.	.	PROPN
biomedich-731	47	43	,	,	PUNCT
biomedich-731	47	44	2019	2019	NUM
biomedich-731	47	45	)	)	PUNCT
biomedich-731	47	46	.	.	PUNCT
biomedich-731	48	1	finally	finally	ADV
biomedich-731	48	2	,	,	PUNCT
biomedich-731	48	3	the	the	DET
biomedich-731	48	4	stability	stability	NOUN
biomedich-731	48	5	of	of	ADP
biomedich-731	48	6	the	the	DET
biomedich-731	48	7	protein	protein	NOUN
biomedich-731	48	8	after	after	SCONJ
biomedich-731	48	9	ligand	ligand	NOUN
biomedich-731	48	10	interaction	interaction	NOUN
biomedich-731	48	11	is	be	AUX
biomedich-731	48	12	evaluated	evaluate	VERB
biomedich-731	48	13	by	by	ADP
biomedich-731	48	14	conducting	conduct	VERB
biomedich-731	48	15	molecular	molecular	ADJ
biomedich-731	48	16	dynamics	dynamic	NOUN
biomedich-731	48	17	(	(	PUNCT
biomedich-731	48	18	md	md	NOUN
biomedich-731	48	19	)	)	PUNCT
biomedich-731	48	20	simulations	simulation	NOUN
biomedich-731	48	21	to	to	PART
biomedich-731	48	22	assess	assess	VERB
biomedich-731	48	23	the	the	DET
biomedich-731	48	24	structure	structure	NOUN
biomedich-731	48	25	's	's	PART
biomedich-731	48	26	stability	stability	NOUN
biomedich-731	48	27	under	under	ADP
biomedich-731	48	28	biologically	biologically	ADV
biomedich-731	48	29	relevant	relevant	ADJ
biomedich-731	48	30	conditions	condition	NOUN
biomedich-731	48	31	.	.	PUNCT
biomedich-731	49	1	this	this	PRON
biomedich-731	49	2	involves	involve	VERB
biomedich-731	49	3	examining	examine	VERB
biomedich-731	49	4	the	the	DET
biomedich-731	49	5	md	md	PROPN
biomedich-731	49	6	simulation	simulation	PROPN
biomedich-731	49	7	trajectories	trajectory	NOUN
biomedich-731	49	8	to	to	PART
biomedich-731	49	9	ensure	ensure	VERB
biomedich-731	49	10	the	the	DET
biomedich-731	49	11	validated	validate	VERB
biomedich-731	49	12	protein	protein	NOUN
biomedich-731	49	13	structure	structure	NOUN
biomedich-731	49	14	remains	remain	VERB
biomedich-731	49	15	stable	stable	ADJ
biomedich-731	49	16	over	over	ADP
biomedich-731	49	17	a	a	DET
biomedich-731	49	18	set	set	ADJ
biomedich-731	49	19	period	period	NOUN
biomedich-731	49	20	.	.	PUNCT
biomedich-731	50	1	these	these	DET
biomedich-731	50	2	steps	step	NOUN
biomedich-731	50	3	are	be	AUX
biomedich-731	50	4	essential	essential	ADJ
biomedich-731	50	5	in	in	ADP
biomedich-731	50	6	the	the	DET
biomedich-731	50	7	protein	protein	NOUN
biomedich-731	50	8	validation	validation	NOUN
biomedich-731	50	9	process	process	NOUN
biomedich-731	50	10	within	within	ADP
biomedich-731	50	11	in	in	ADP
biomedich-731	50	12	silico	silico	NOUN
biomedich-731	50	13	analysis	analysis	NOUN
biomedich-731	50	14	,	,	PUNCT
biomedich-731	50	15	ensuring	ensure	VERB
biomedich-731	50	16	that	that	SCONJ
biomedich-731	50	17	the	the	DET
biomedich-731	50	18	structure	structure	NOUN
biomedich-731	50	19	used	use	VERB
biomedich-731	50	20	in	in	ADP
biomedich-731	50	21	experiments	experiment	NOUN
biomedich-731	50	22	can	can	AUX
biomedich-731	50	23	predict	predict	VERB
biomedich-731	50	24	ligand	ligand	NOUN
biomedich-731	50	25	interactions	interaction	NOUN
biomedich-731	50	26	accurately	accurately	ADV
biomedich-731	50	27	and	and	CCONJ
biomedich-731	50	28	support	support	VERB
biomedich-731	50	29	further	further	ADJ
biomedich-731	50	30	analysis	analysis	NOUN
biomedich-731	50	31	regarding	regard	VERB
biomedich-731	50	32	the	the	DET
biomedich-731	50	33	desired	desire	VERB
biomedich-731	50	34	biological	biological	ADJ
biomedich-731	50	35	activity	activity	NOUN
biomedich-731	50	36	.	.	PUNCT
biomedich-731	51	1	molecular	molecular	ADJ
biomedich-731	51	2	docking	docking	NOUN
biomedich-731	51	3	process	process	NOUN
biomedich-731	51	4	molecular	molecular	ADJ
biomedich-731	51	5	docking	docking	NOUN
biomedich-731	51	6	simulations	simulation	NOUN
biomedich-731	51	7	were	be	AUX
biomedich-731	51	8	performed	perform	VERB
biomedich-731	51	9	using	use	VERB
biomedich-731	51	10	pyrx	pyrx	NOUN
biomedich-731	51	11	,	,	PUNCT
biomedich-731	51	12	an	an	DET
biomedich-731	51	13	open	open	ADJ
biomedich-731	51	14	-	-	PUNCT
biomedich-731	51	15	source	source	NOUN
biomedich-731	51	16	software	software	NOUN
biomedich-731	51	17	integrating	integrate	VERB
biomedich-731	51	18	autodock	autodock	PROPN
biomedich-731	51	19	vina	vina	PROPN
biomedich-731	51	20	.	.	PUNCT
biomedich-731	52	1	this	this	DET
biomedich-731	52	2	study	study	NOUN
biomedich-731	52	3	focused	focus	VERB
biomedich-731	52	4	on	on	ADP
biomedich-731	52	5	calculating	calculate	VERB
biomedich-731	52	6	the	the	DET
biomedich-731	52	7	binding	bind	VERB
biomedich-731	52	8	affinity	affinity	NOUN
biomedich-731	52	9	of	of	ADP
biomedich-731	52	10	4	4	NUM
biomedich-731	52	11	-	-	PUNCT
biomedich-731	52	12	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	52	13	to	to	ADP
biomedich-731	52	14	the	the	DET
biomedich-731	52	15	active	active	ADJ
biomedich-731	52	16	site	site	NOUN
biomedich-731	52	17	of	of	ADP
biomedich-731	52	18	dpp4	dpp4	PROPN
biomedich-731	52	19	.	.	PUNCT
biomedich-731	53	1	grid	grid	PROPN
biomedich-731	53	2	box	box	PROPN
biomedich-731	53	3	parameters	parameter	NOUN
biomedich-731	53	4	were	be	AUX
biomedich-731	53	5	set	set	VERB
biomedich-731	53	6	to	to	PART
biomedich-731	53	7	encompass	encompass	VERB
biomedich-731	53	8	the	the	DET
biomedich-731	53	9	entire	entire	ADJ
biomedich-731	53	10	binding	bind	VERB
biomedich-731	53	11	site	site	NOUN
biomedich-731	53	12	of	of	ADP
biomedich-731	53	13	dpp4	dpp4	PROPN
biomedich-731	53	14	,	,	PUNCT
biomedich-731	53	15	ensuring	ensure	VERB
biomedich-731	53	16	comprehensive	comprehensive	ADJ
biomedich-731	53	17	coverage	coverage	NOUN
biomedich-731	53	18	for	for	ADP
biomedich-731	53	19	ligand	ligand	NOUN
biomedich-731	53	20	-	-	PUNCT
biomedich-731	53	21	receptor	receptor	NOUN
biomedich-731	53	22	interactions	interaction	NOUN
biomedich-731	53	23	.	.	PUNCT
biomedich-731	54	1	the	the	DET
biomedich-731	54	2	docking	docking	NOUN
biomedich-731	54	3	process	process	NOUN
biomedich-731	54	4	began	begin	VERB
biomedich-731	54	5	with	with	ADP
biomedich-731	54	6	loading	load	VERB
biomedich-731	54	7	the	the	DET
biomedich-731	54	8	prepared	prepared	ADJ
biomedich-731	54	9	protein	protein	NOUN
biomedich-731	54	10	and	and	CCONJ
biomedich-731	54	11	ligand	ligand	ADJ
biomedich-731	54	12	files	file	NOUN
biomedich-731	54	13	into	into	ADP
biomedich-731	54	14	pyrx	pyrx	NOUN
biomedich-731	54	15	.	.	PUNCT
biomedich-731	55	1	the	the	DET
biomedich-731	55	2	protein	protein	NOUN
biomedich-731	55	3	was	be	AUX
biomedich-731	55	4	fixed	fix	VERB
biomedich-731	55	5	as	as	ADP
biomedich-731	55	6	rigid	rigid	ADJ
biomedich-731	55	7	,	,	PUNCT
biomedich-731	55	8	while	while	SCONJ
biomedich-731	55	9	the	the	DET
biomedich-731	55	10	ligand	ligand	NOUN
biomedich-731	55	11	was	be	AUX
biomedich-731	55	12	treated	treat	VERB
biomedich-731	55	13	as	as	ADP
biomedich-731	55	14	flexible	flexible	ADJ
biomedich-731	55	15	to	to	PART
biomedich-731	55	16	allow	allow	VERB
biomedich-731	55	17	for	for	ADP
biomedich-731	55	18	accurate	accurate	ADJ
biomedich-731	55	19	conformational	conformational	ADJ
biomedich-731	55	20	adjustments	adjustment	NOUN
biomedich-731	55	21	during	during	ADP
biomedich-731	55	22	docking	docking	NOUN
biomedich-731	55	23	.	.	PUNCT
biomedich-731	56	1	docking	docking	NOUN
biomedich-731	56	2	results	result	NOUN
biomedich-731	56	3	were	be	AUX
biomedich-731	56	4	generated	generate	VERB
biomedich-731	56	5	as	as	ADP
biomedich-731	56	6	binding	bind	VERB
biomedich-731	56	7	affinity	affinity	NOUN
biomedich-731	56	8	values	value	NOUN
biomedich-731	56	9	in	in	ADP
biomedich-731	56	10	kcal	kcal	PROPN
biomedich-731	56	11	/	/	SYM
biomedich-731	56	12	mol	mol	PROPN
biomedich-731	56	13	,	,	PUNCT
biomedich-731	56	14	which	which	PRON
biomedich-731	56	15	reflect	reflect	VERB
biomedich-731	56	16	the	the	DET
biomedich-731	56	17	stability	stability	NOUN
biomedich-731	56	18	of	of	ADP
biomedich-731	56	19	the	the	DET
biomedich-731	56	20	proteinligand	proteinligand	ADJ
biomedich-731	56	21	complex	complex	NOUN
biomedich-731	56	22	(	(	PUNCT
biomedich-731	56	23	suciana	suciana	PROPN
biomedich-731	56	24	&	&	CCONJ
biomedich-731	56	25	arifianto	arifianto	PROPN
biomedich-731	56	26	,	,	PUNCT
biomedich-731	56	27	2019	2019	NUM
biomedich-731	56	28	)	)	PUNCT
biomedich-731	56	29	post	post	NOUN
biomedich-731	56	30	docking	docking	NOUN
biomedich-731	56	31	visualization	visualization	NOUN
biomedich-731	56	32	post	post	ADJ
biomedich-731	56	33	-	-	ADJ
biomedich-731	56	34	docking	docking	ADJ
biomedich-731	56	35	visualization	visualization	NOUN
biomedich-731	56	36	is	be	AUX
biomedich-731	56	37	a	a	DET
biomedich-731	56	38	crucial	crucial	ADJ
biomedich-731	56	39	step	step	NOUN
biomedich-731	56	40	after	after	ADP
biomedich-731	56	41	completing	complete	VERB
biomedich-731	56	42	the	the	DET
biomedich-731	56	43	docking	docking	NOUN
biomedich-731	56	44	process	process	NOUN
biomedich-731	56	45	.	.	PUNCT
biomedich-731	57	1	for	for	ADP
biomedich-731	57	2	instance	instance	NOUN
biomedich-731	57	3	,	,	PUNCT
biomedich-731	57	4	after	after	ADP
biomedich-731	57	5	docking	dock	VERB
biomedich-731	57	6	the	the	DET
biomedich-731	57	7	protein	protein	NOUN
biomedich-731	57	8	and	and	CCONJ
biomedich-731	57	9	ligand	ligand	NOUN
biomedich-731	57	10	using	use	VERB
biomedich-731	57	11	a	a	DET
biomedich-731	57	12	tool	tool	NOUN
biomedich-731	57	13	like	like	ADP
biomedich-731	57	14	pyrx	pyrx	NOUN
biomedich-731	57	15	,	,	PUNCT
biomedich-731	57	16	the	the	DET
biomedich-731	57	17	resulting	result	VERB
biomedich-731	57	18	data	datum	NOUN
biomedich-731	57	19	is	be	AUX
biomedich-731	57	20	saved	save	VERB
biomedich-731	57	21	for	for	ADP
biomedich-731	57	22	further	further	ADJ
biomedich-731	57	23	analysis	analysis	NOUN
biomedich-731	57	24	.	.	PUNCT
biomedich-731	58	1	this	this	DET
biomedich-731	58	2	data	datum	NOUN
biomedich-731	58	3	,	,	PUNCT
biomedich-731	58	4	typically	typically	ADV
biomedich-731	58	5	containing	contain	VERB
biomedich-731	58	6	the	the	DET
biomedich-731	58	7	docking	docking	NOUN
biomedich-731	58	8	poses	pose	NOUN
biomedich-731	58	9	and	and	CCONJ
biomedich-731	58	10	binding	bind	VERB
biomedich-731	58	11	energies	energy	NOUN
biomedich-731	58	12	,	,	PUNCT
biomedich-731	58	13	is	be	AUX
biomedich-731	58	14	then	then	ADV
biomedich-731	58	15	visualized	visualize	VERB
biomedich-731	58	16	using	use	VERB
biomedich-731	58	17	pymol	pymol	PROPN
biomedich-731	58	18	to	to	PART
biomedich-731	58	19	allow	allow	VERB
biomedich-731	58	20	better	well	ADV
biomedich-731	58	21	understand	understand	VERB
biomedich-731	58	22	the	the	DET
biomedich-731	58	23	interaction	interaction	NOUN
biomedich-731	58	24	between	between	ADP
biomedich-731	58	25	the	the	DET
biomedich-731	58	26	ligand	ligand	NOUN
biomedich-731	58	27	and	and	CCONJ
biomedich-731	58	28	the	the	DET
biomedich-731	58	29	protein	protein	NOUN
biomedich-731	58	30	.	.	PUNCT
biomedich-731	59	1	by	by	ADP
biomedich-731	59	2	reloading	reload	VERB
biomedich-731	59	3	the	the	DET
biomedich-731	59	4	docking	docking	NOUN
biomedich-731	59	5	results	result	NOUN
biomedich-731	59	6	in	in	ADP
biomedich-731	59	7	pymol	pymol	PROPN
biomedich-731	59	8	,	,	PUNCT
biomedich-731	59	9	the	the	DET
biomedich-731	59	10	researcher	researcher	NOUN
biomedich-731	59	11	can	can	AUX
biomedich-731	59	12	easily	easily	ADV
biomedich-731	59	13	identify	identify	VERB
biomedich-731	59	14	key	key	ADJ
biomedich-731	59	15	details	detail	NOUN
biomedich-731	59	16	,	,	PUNCT
biomedich-731	59	17	such	such	ADJ
biomedich-731	59	18	as	as	ADP
biomedich-731	59	19	the	the	DET
biomedich-731	59	20	types	type	NOUN
biomedich-731	59	21	of	of	ADP
biomedich-731	59	22	bonds	bond	NOUN
biomedich-731	59	23	formed	form	VERB
biomedich-731	59	24	(	(	PUNCT
biomedich-731	59	25	hydrogen	hydrogen	NOUN
biomedich-731	59	26	bonds	bond	NOUN
biomedich-731	59	27	,	,	PUNCT
biomedich-731	59	28	hydrophobic	hydrophobic	NOUN
biomedich-731	59	29	interactions	interaction	NOUN
biomedich-731	59	30	,	,	PUNCT
biomedich-731	59	31	or	or	CCONJ
biomedich-731	59	32	ionic	ionic	ADJ
biomedich-731	59	33	bonds	bond	NOUN
biomedich-731	59	34	)	)	PUNCT
biomedich-731	59	35	between	between	ADP
biomedich-731	59	36	the	the	DET
biomedich-731	59	37	ligand	ligand	NOUN
biomedich-731	59	38	and	and	CCONJ
biomedich-731	59	39	the	the	DET
biomedich-731	59	40	thalib	thalib	PROPN
biomedich-731	59	41	&	&	CCONJ
biomedich-731	59	42	damayanti	damayanti	PROPN
biomedich-731	59	43	–	–	PUNCT
biomedich-731	59	44	4	4	NUM
biomedich-731	59	45	-	-	NOUN
biomedich-731	59	46	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	59	47	as	as	ADP
biomedich-731	59	48	a	a	DET
biomedich-731	59	49	natural	natural	ADJ
biomedich-731	59	50	dpp-4	dpp-4	ADJ
biomedich-731	59	51	inhibitor	inhibitor	NOUN
biomedich-731	59	52	for	for	ADP
biomedich-731	59	53	diabetes	diabetes	NOUN
biomedich-731	59	54	411	411	NUM
biomedich-731	59	55	protein	protein	NOUN
biomedich-731	59	56	.	.	PUNCT
biomedich-731	60	1	this	this	DET
biomedich-731	60	2	visualization	visualization	NOUN
biomedich-731	60	3	helps	help	VERB
biomedich-731	60	4	determine	determine	VERB
biomedich-731	60	5	the	the	DET
biomedich-731	60	6	precise	precise	ADJ
biomedich-731	60	7	binding	bind	VERB
biomedich-731	60	8	site	site	NOUN
biomedich-731	60	9	on	on	ADP
biomedich-731	60	10	the	the	DET
biomedich-731	60	11	protein	protein	NOUN
biomedich-731	60	12	,	,	PUNCT
biomedich-731	60	13	the	the	DET
biomedich-731	60	14	orientation	orientation	NOUN
biomedich-731	60	15	of	of	ADP
biomedich-731	60	16	the	the	DET
biomedich-731	60	17	ligand	ligand	NOUN
biomedich-731	60	18	within	within	ADP
biomedich-731	60	19	the	the	DET
biomedich-731	60	20	binding	bind	VERB
biomedich-731	60	21	pocket	pocket	NOUN
biomedich-731	60	22	,	,	PUNCT
biomedich-731	60	23	and	and	CCONJ
biomedich-731	60	24	the	the	DET
biomedich-731	60	25	strength	strength	NOUN
biomedich-731	60	26	of	of	ADP
biomedich-731	60	27	the	the	DET
biomedich-731	60	28	interactions	interaction	NOUN
biomedich-731	60	29	,	,	PUNCT
biomedich-731	60	30	which	which	PRON
biomedich-731	60	31	are	be	AUX
biomedich-731	60	32	crucial	crucial	ADJ
biomedich-731	60	33	for	for	ADP
biomedich-731	60	34	evaluating	evaluate	VERB
biomedich-731	60	35	the	the	DET
biomedich-731	60	36	potential	potential	ADJ
biomedich-731	60	37	efficacy	efficacy	NOUN
biomedich-731	60	38	of	of	ADP
biomedich-731	60	39	the	the	DET
biomedich-731	60	40	ligand	ligand	NOUN
biomedich-731	60	41	as	as	ADP
biomedich-731	60	42	a	a	DET
biomedich-731	60	43	therapeutic	therapeutic	ADJ
biomedich-731	60	44	agent	agent	NOUN
biomedich-731	60	45	.	.	PUNCT
biomedich-731	61	1	results	result	NOUN
biomedich-731	61	2	and	and	CCONJ
biomedich-731	61	3	discussion	discussion	NOUN
biomedich-731	61	4	ligand	ligand	NOUN
biomedich-731	61	5	and	and	CCONJ
biomedich-731	61	6	protein	protein	NOUN
biomedich-731	61	7	preparation	preparation	NOUN
biomedich-731	61	8	figure	figure	NOUN
biomedich-731	61	9	1	1	NUM
biomedich-731	61	10	.	.	PUNCT
biomedich-731	62	1	the	the	DET
biomedich-731	62	2	ramachandran	ramachandran	PROPN
biomedich-731	62	3	procheck	procheck	NOUN
biomedich-731	62	4	.	.	PUNCT
biomedich-731	63	1	before	before	ADP
biomedich-731	63	2	beginning	begin	VERB
biomedich-731	63	3	the	the	DET
biomedich-731	63	4	molecular	molecular	ADJ
biomedich-731	63	5	docking	docking	NOUN
biomedich-731	63	6	studies	study	NOUN
biomedich-731	63	7	,	,	PUNCT
biomedich-731	63	8	the	the	DET
biomedich-731	63	9	ligand	ligand	NOUN
biomedich-731	63	10	and	and	CCONJ
biomedich-731	63	11	the	the	DET
biomedich-731	63	12	protein	protein	NOUN
biomedich-731	63	13	(	(	PUNCT
biomedich-731	63	14	dpp4	dpp4	PROPN
biomedich-731	63	15	)	)	PUNCT
biomedich-731	63	16	were	be	AUX
biomedich-731	63	17	prepared	prepare	VERB
biomedich-731	63	18	.	.	PUNCT
biomedich-731	64	1	the	the	DET
biomedich-731	64	2	3d	3d	PROPN
biomedich-731	64	3	structure	structure	NOUN
biomedich-731	64	4	of	of	ADP
biomedich-731	64	5	4	4	NUM
biomedich-731	64	6	-	-	PUNCT
biomedich-731	64	7	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	64	8	was	be	AUX
biomedich-731	64	9	obtained	obtain	VERB
biomedich-731	64	10	from	from	ADP
biomedich-731	64	11	the	the	DET
biomedich-731	64	12	pubchem	pubchem	NOUN
biomedich-731	64	13	database	database	NOUN
biomedich-731	64	14	.	.	PUNCT
biomedich-731	65	1	the	the	DET
biomedich-731	65	2	optimized	optimize	VERB
biomedich-731	65	3	structure	structure	NOUN
biomedich-731	65	4	was	be	AUX
biomedich-731	65	5	minimized	minimize	VERB
biomedich-731	65	6	to	to	PART
biomedich-731	65	7	ensure	ensure	VERB
biomedich-731	65	8	the	the	DET
biomedich-731	65	9	ligand	ligand	NOUN
biomedich-731	65	10	’s	’s	PART
biomedich-731	65	11	conformation	conformation	NOUN
biomedich-731	65	12	was	be	AUX
biomedich-731	65	13	energetically	energetically	ADV
biomedich-731	65	14	favorable	favorable	ADJ
biomedich-731	65	15	for	for	ADP
biomedich-731	65	16	docking	docking	NOUN
biomedich-731	65	17	.	.	PUNCT
biomedich-731	66	1	for	for	ADP
biomedich-731	66	2	the	the	DET
biomedich-731	66	3	protein	protein	NOUN
biomedich-731	66	4	preparation	preparation	NOUN
biomedich-731	66	5	,	,	PUNCT
biomedich-731	66	6	the	the	DET
biomedich-731	66	7	crystal	crystal	NOUN
biomedich-731	66	8	structure	structure	NOUN
biomedich-731	66	9	of	of	ADP
biomedich-731	66	10	dpp4	dpp4	PROPN
biomedich-731	66	11	was	be	AUX
biomedich-731	66	12	retrieved	retrieve	VERB
biomedich-731	66	13	from	from	ADP
biomedich-731	66	14	the	the	DET
biomedich-731	66	15	protein	protein	NOUN
biomedich-731	66	16	data	datum	NOUN
biomedich-731	66	17	bank	bank	PROPN
biomedich-731	66	18	(	(	PUNCT
biomedich-731	66	19	pdb	pdb	PROPN
biomedich-731	66	20	i	i	PROPN
biomedich-731	66	21	d	d	PROPN
biomedich-731	66	22	:	:	PUNCT
biomedich-731	66	23	4wz5	4wz5	NUM
biomedich-731	66	24	)	)	PUNCT
biomedich-731	66	25	(	(	PUNCT
biomedich-731	66	26	setiawansyah	setiawansyah	NOUN
biomedich-731	66	27	et	et	PROPN
biomedich-731	66	28	al	al	PROPN
biomedich-731	66	29	.	.	PROPN
biomedich-731	66	30	,	,	PUNCT
biomedich-731	66	31	2022	2022	NUM
biomedich-731	66	32	)	)	PUNCT
biomedich-731	66	33	.	.	PUNCT
biomedich-731	67	1	the	the	DET
biomedich-731	67	2	protein	protein	NOUN
biomedich-731	67	3	was	be	AUX
biomedich-731	67	4	cleaned	clean	VERB
biomedich-731	67	5	by	by	ADP
biomedich-731	67	6	removing	remove	VERB
biomedich-731	67	7	water	water	NOUN
biomedich-731	67	8	molecules	molecule	NOUN
biomedich-731	67	9	and	and	CCONJ
biomedich-731	67	10	heteroatoms	heteroatom	NOUN
biomedich-731	67	11	that	that	PRON
biomedich-731	67	12	could	could	AUX
biomedich-731	67	13	interfere	interfere	VERB
biomedich-731	67	14	with	with	ADP
biomedich-731	67	15	docking	docking	NOUN
biomedich-731	67	16	,	,	PUNCT
biomedich-731	67	17	and	and	CCONJ
biomedich-731	67	18	it	it	PRON
biomedich-731	67	19	was	be	AUX
biomedich-731	67	20	also	also	ADV
biomedich-731	67	21	protonated	protonate	VERB
biomedich-731	67	22	to	to	PART
biomedich-731	67	23	ensure	ensure	VERB
biomedich-731	67	24	proper	proper	ADJ
biomedich-731	67	25	hydrogen	hydrogen	NOUN
biomedich-731	67	26	bonding	bonding	NOUN
biomedich-731	67	27	during	during	ADP
biomedich-731	67	28	interaction	interaction	NOUN
biomedich-731	67	29	with	with	ADP
biomedich-731	67	30	the	the	DET
biomedich-731	67	31	ligand	ligand	NOUN
biomedich-731	67	32	.	.	PUNCT
biomedich-731	68	1	the	the	DET
biomedich-731	68	2	protein	protein	NOUN
biomedich-731	68	3	was	be	AUX
biomedich-731	68	4	then	then	ADV
biomedich-731	68	5	prepared	prepare	VERB
biomedich-731	68	6	using	use	VERB
biomedich-731	68	7	autodocktools	autodocktool	NOUN
biomedich-731	68	8	,	,	PUNCT
biomedich-731	68	9	and	and	CCONJ
biomedich-731	68	10	its	its	PRON
biomedich-731	68	11	grid	grid	NOUN
biomedich-731	68	12	box	box	NOUN
biomedich-731	68	13	was	be	AUX
biomedich-731	68	14	defined	define	VERB
biomedich-731	68	15	to	to	PART
biomedich-731	68	16	cover	cover	VERB
biomedich-731	68	17	the	the	DET
biomedich-731	68	18	binding	bind	VERB
biomedich-731	68	19	site	site	NOUN
biomedich-731	68	20	.	.	PUNCT
biomedich-731	69	1	structural	structural	ADJ
biomedich-731	69	2	validation	validation	NOUN
biomedich-731	69	3	of	of	ADP
biomedich-731	69	4	dpp4	dpp4	PROPN
biomedich-731	69	5	protein	protein	NOUN
biomedich-731	69	6	structural	structural	ADJ
biomedich-731	69	7	validation	validation	NOUN
biomedich-731	69	8	of	of	ADP
biomedich-731	69	9	the	the	DET
biomedich-731	69	10	dpp4	dpp4	PROPN
biomedich-731	69	11	protein	protein	NOUN
biomedich-731	69	12	model	model	NOUN
biomedich-731	69	13	was	be	AUX
biomedich-731	69	14	conducted	conduct	VERB
biomedich-731	69	15	using	use	VERB
biomedich-731	69	16	procheck	procheck	NOUN
biomedich-731	69	17	(	(	PUNCT
biomedich-731	69	18	figure	figure	NOUN
biomedich-731	69	19	1	1	NUM
biomedich-731	69	20	.	.	PUNCT
biomedich-731	69	21	)	)	PUNCT
biomedich-731	70	1	and	and	CCONJ
biomedich-731	70	2	errat	errat	NOUN
biomedich-731	70	3	tools	tool	NOUN
biomedich-731	70	4	(	(	PUNCT
biomedich-731	70	5	figure	figure	NOUN
biomedich-731	70	6	2	2	NUM
biomedich-731	70	7	.	.	PUNCT
biomedich-731	70	8	)	)	PUNCT
biomedich-731	70	9	.	.	PUNCT
biomedich-731	71	1	the	the	DET
biomedich-731	71	2	ramachandran	ramachandran	PROPN
biomedich-731	71	3	plot	plot	NOUN
biomedich-731	71	4	(	(	PUNCT
biomedich-731	71	5	figure	figure	NOUN
biomedich-731	71	6	1	1	NUM
biomedich-731	71	7	.	.	PUNCT
biomedich-731	71	8	)	)	PUNCT
biomedich-731	71	9	revealed	reveal	VERB
biomedich-731	71	10	that	that	SCONJ
biomedich-731	71	11	89.4	89.4	NUM
biomedich-731	71	12	%	%	NOUN
biomedich-731	71	13	of	of	ADP
biomedich-731	71	14	residues	residue	NOUN
biomedich-731	71	15	were	be	AUX
biomedich-731	71	16	in	in	ADP
biomedich-731	71	17	the	the	DET
biomedich-731	71	18	most	most	ADV
biomedich-731	71	19	favored	favor	VERB
biomedich-731	71	20	regions	region	NOUN
biomedich-731	71	21	,	,	PUNCT
biomedich-731	71	22	with	with	ADP
biomedich-731	71	23	9.2	9.2	NUM
biomedich-731	71	24	%	%	NOUN
biomedich-731	71	25	in	in	ADP
biomedich-731	71	26	additional	additional	ADJ
biomedich-731	71	27	allowed	allow	VERB
biomedich-731	71	28	regions	region	NOUN
biomedich-731	71	29	and	and	CCONJ
biomedich-731	71	30	only	only	ADV
biomedich-731	71	31	1.4	1.4	NUM
biomedich-731	71	32	%	%	NOUN
biomedich-731	71	33	in	in	ADP
biomedich-731	71	34	disallowed	disallow	VERB
biomedich-731	71	35	regions	region	NOUN
biomedich-731	71	36	.	.	PUNCT
biomedich-731	72	1	errat	errat	NOUN
biomedich-731	72	2	analysis	analysis	NOUN
biomedich-731	72	3	(	(	PUNCT
biomedich-731	72	4	figure	figure	NOUN
biomedich-731	72	5	2	2	NUM
biomedich-731	72	6	.	.	PUNCT
biomedich-731	72	7	)	)	PUNCT
biomedich-731	72	8	yielded	yield	VERB
biomedich-731	72	9	a	a	DET
biomedich-731	72	10	quality	quality	NOUN
biomedich-731	72	11	score	score	NOUN
biomedich-731	72	12	of	of	ADP
biomedich-731	72	13	95.7	95.7	NUM
biomedich-731	72	14	%	%	NOUN
biomedich-731	72	15	,	,	PUNCT
biomedich-731	72	16	confirming	confirm	VERB
biomedich-731	72	17	the	the	DET
biomedich-731	72	18	reliability	reliability	NOUN
biomedich-731	72	19	of	of	ADP
biomedich-731	72	20	the	the	DET
biomedich-731	72	21	dpp4	dpp4	PROPN
biomedich-731	72	22	model	model	NOUN
biomedich-731	72	23	for	for	ADP
biomedich-731	72	24	molecular	molecular	ADJ
biomedich-731	72	25	docking	docking	NOUN
biomedich-731	72	26	studies	study	NOUN
biomedich-731	72	27	.	.	PUNCT
biomedich-731	73	1	this	this	DET
biomedich-731	73	2	validation	validation	NOUN
biomedich-731	73	3	ensures	ensure	VERB
biomedich-731	73	4	the	the	DET
biomedich-731	73	5	robustness	robustness	NOUN
biomedich-731	73	6	of	of	ADP
biomedich-731	73	7	the	the	DET
biomedich-731	73	8	results	result	NOUN
biomedich-731	73	9	and	and	CCONJ
biomedich-731	73	10	strengthens	strengthen	VERB
biomedich-731	73	11	the	the	DET
biomedich-731	73	12	credibility	credibility	NOUN
biomedich-731	73	13	of	of	ADP
biomedich-731	73	14	4	4	NUM
biomedich-731	73	15	-	-	PUNCT
biomedich-731	73	16	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	73	17	as	as	ADP
biomedich-731	73	18	a	a	DET
biomedich-731	73	19	potential	potential	ADJ
biomedich-731	73	20	drug	drug	NOUN
biomedich-731	73	21	candidate	candidate	NOUN
biomedich-731	73	22	.	.	PUNCT
biomedich-731	74	1	figure	figure	NOUN
biomedich-731	74	2	2	2	NUM
biomedich-731	74	3	.	.	PUNCT
biomedich-731	75	1	structure	structure	NOUN
biomedich-731	75	2	of	of	ADP
biomedich-731	75	3	errat	errat	NOUN
biomedich-731	75	4	tools	tool	NOUN
biomedich-731	75	5	.	.	PUNCT
biomedich-731	76	1	docking	docking	NOUN
biomedich-731	76	2	results	result	VERB
biomedich-731	76	3	the	the	PRON
biomedich-731	76	4	in	in	ADP
biomedich-731	76	5	silico	silico	NOUN
biomedich-731	76	6	analysis	analysis	NOUN
biomedich-731	76	7	of	of	ADP
biomedich-731	76	8	4	4	NUM
biomedich-731	76	9	-	-	PUNCT
biomedich-731	76	10	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	76	11	as	as	SCONJ
biomedich-731	76	12	a	a	DET
biomedich-731	76	13	natural	natural	ADJ
biomedich-731	76	14	antidiabetic	antidiabetic	ADJ
biomedich-731	76	15	agent	agent	NOUN
biomedich-731	76	16	focuses	focus	VERB
biomedich-731	76	17	on	on	ADP
biomedich-731	76	18	the	the	DET
biomedich-731	76	19	interaction	interaction	NOUN
biomedich-731	76	20	between	between	ADP
biomedich-731	76	21	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	76	22	and	and	CCONJ
biomedich-731	76	23	the	the	DET
biomedich-731	76	24	target	target	NOUN
biomedich-731	76	25	enzyme	enzyme	NOUN
biomedich-731	76	26	dpp-4	dpp-4	ADJ
biomedich-731	76	27	.	.	PUNCT
biomedich-731	77	1	molecular	molecular	ADJ
biomedich-731	77	2	docking	docking	NOUN
biomedich-731	77	3	was	be	AUX
biomedich-731	77	4	performed	perform	VERB
biomedich-731	77	5	to	to	PART
biomedich-731	77	6	predict	predict	VERB
biomedich-731	77	7	the	the	DET
biomedich-731	77	8	binding	binding	NOUN
biomedich-731	77	9	between	between	ADP
biomedich-731	77	10	the	the	DET
biomedich-731	77	11	ligand	ligand	NOUN
biomedich-731	77	12	(	(	PUNCT
biomedich-731	77	13	in	in	ADP
biomedich-731	77	14	this	this	DET
biomedich-731	77	15	case	case	NOUN
biomedich-731	77	16	,	,	PUNCT
biomedich-731	77	17	4	4	NUM
biomedich-731	77	18	-	-	NOUN
biomedich-731	77	19	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	77	20	)	)	PUNCT
biomedich-731	77	21	and	and	CCONJ
biomedich-731	77	22	the	the	DET
biomedich-731	77	23	active	active	ADJ
biomedich-731	77	24	site	site	NOUN
biomedich-731	77	25	of	of	ADP
biomedich-731	77	26	the	the	DET
biomedich-731	77	27	dpp-4	dpp-4	ADJ
biomedich-731	77	28	enzyme	enzyme	NOUN
biomedich-731	77	29	,	,	PUNCT
biomedich-731	77	30	a	a	DET
biomedich-731	77	31	primary	primary	ADJ
biomedich-731	77	32	target	target	NOUN
biomedich-731	77	33	in	in	ADP
biomedich-731	77	34	glucose	glucose	NOUN
biomedich-731	77	35	regulation	regulation	NOUN
biomedich-731	77	36	in	in	ADP
biomedich-731	77	37	diabetes	diabetes	NOUN
biomedich-731	77	38	.	.	PUNCT
biomedich-731	78	1	the	the	DET
biomedich-731	78	2	docking	docking	NOUN
biomedich-731	78	3	results	result	VERB
biomedich-731	78	4	412	412	NUM
biomedich-731	78	5	biology	biology	NOUN
biomedich-731	78	6	,	,	PUNCT
biomedich-731	78	7	medicine	medicine	NOUN
biomedich-731	78	8	,	,	PUNCT
biomedich-731	78	9	&	&	CCONJ
biomedich-731	78	10	natural	natural	ADJ
biomedich-731	78	11	product	product	NOUN
biomedich-731	78	12	chemistry	chemistry	NOUN
biomedich-731	78	13	14	14	NUM
biomedich-731	78	14	(	(	PUNCT
biomedich-731	78	15	1	1	NUM
biomedich-731	78	16	)	)	PUNCT
biomedich-731	78	17	,	,	PUNCT
biomedich-731	78	18	2025	2025	NUM
biomedich-731	78	19	:	:	PUNCT
biomedich-731	78	20	409	409	NUM
biomedich-731	78	21	-	-	SYM
biomedich-731	78	22	415	415	NUM
biomedich-731	78	23	provide	provide	VERB
biomedich-731	78	24	insights	insight	NOUN
biomedich-731	78	25	into	into	ADP
biomedich-731	78	26	the	the	DET
biomedich-731	78	27	strength	strength	NOUN
biomedich-731	78	28	of	of	ADP
biomedich-731	78	29	the	the	DET
biomedich-731	78	30	interaction	interaction	NOUN
biomedich-731	78	31	and	and	CCONJ
biomedich-731	78	32	the	the	DET
biomedich-731	78	33	stability	stability	NOUN
biomedich-731	78	34	of	of	ADP
biomedich-731	78	35	the	the	DET
biomedich-731	78	36	binding	binding	NOUN
biomedich-731	78	37	between	between	ADP
biomedich-731	78	38	4	4	NUM
biomedich-731	78	39	-	-	PUNCT
biomedich-731	78	40	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	78	41	and	and	CCONJ
biomedich-731	78	42	dpp-4	dpp-4	X
biomedich-731	78	43	,	,	PUNCT
biomedich-731	78	44	as	as	ADV
biomedich-731	78	45	well	well	ADV
biomedich-731	78	46	as	as	ADP
biomedich-731	78	47	the	the	DET
biomedich-731	78	48	potential	potential	NOUN
biomedich-731	78	49	of	of	ADP
biomedich-731	78	50	this	this	DET
biomedich-731	78	51	compound	compound	NOUN
biomedich-731	78	52	in	in	ADP
biomedich-731	78	53	inhibiting	inhibit	VERB
biomedich-731	78	54	enzyme	enzyme	NOUN
biomedich-731	78	55	activity	activity	NOUN
biomedich-731	78	56	.	.	PUNCT
biomedich-731	79	1	the	the	DET
biomedich-731	79	2	main	main	ADJ
biomedich-731	79	3	docking	docking	NOUN
biomedich-731	79	4	results	result	NOUN
biomedich-731	79	5	show	show	VERB
biomedich-731	79	6	that	that	SCONJ
biomedich-731	79	7	4	4	NUM
biomedich-731	79	8	-	-	PUNCT
biomedich-731	79	9	hydroxyisoleucine	hydroxyisoleucine	PROPN
biomedich-731	79	10	has	have	VERB
biomedich-731	79	11	a	a	DET
biomedich-731	79	12	good	good	ADJ
biomedich-731	79	13	affinity	affinity	NOUN
biomedich-731	79	14	for	for	ADP
biomedich-731	79	15	the	the	DET
biomedich-731	79	16	dpp-4	dpp-4	ADV
biomedich-731	79	17	active	active	ADJ
biomedich-731	79	18	site	site	NOUN
biomedich-731	79	19	.	.	PUNCT
biomedich-731	80	1	based	base	VERB
biomedich-731	80	2	on	on	ADP
biomedich-731	80	3	the	the	DET
biomedich-731	80	4	docking	docking	NOUN
biomedich-731	80	5	scores	score	NOUN
biomedich-731	80	6	calculated	calculate	VERB
biomedich-731	80	7	,	,	PUNCT
biomedich-731	80	8	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	80	9	forms	form	NOUN
biomedich-731	80	10	stable	stable	ADJ
biomedich-731	80	11	interactions	interaction	NOUN
biomedich-731	80	12	with	with	ADP
biomedich-731	80	13	several	several	ADJ
biomedich-731	80	14	important	important	ADJ
biomedich-731	80	15	residues	residue	NOUN
biomedich-731	80	16	in	in	ADP
biomedich-731	80	17	the	the	DET
biomedich-731	80	18	active	active	ADJ
biomedich-731	80	19	site	site	NOUN
biomedich-731	80	20	of	of	ADP
biomedich-731	80	21	the	the	DET
biomedich-731	80	22	dpp-4	dpp-4	ADJ
biomedich-731	80	23	enzyme	enzyme	NOUN
biomedich-731	80	24	,	,	PUNCT
biomedich-731	80	25	which	which	PRON
biomedich-731	80	26	are	be	AUX
biomedich-731	80	27	involved	involve	VERB
biomedich-731	80	28	in	in	ADP
biomedich-731	80	29	inhibiting	inhibit	VERB
biomedich-731	80	30	its	its	PRON
biomedich-731	80	31	activity	activity	NOUN
biomedich-731	80	32	.	.	PUNCT
biomedich-731	81	1	this	this	DET
biomedich-731	81	2	molecule	molecule	NOUN
biomedich-731	81	3	can	can	AUX
biomedich-731	81	4	to	to	ADP
biomedich-731	81	5	functional	functional	ADJ
biomedich-731	81	6	groups	group	NOUN
biomedich-731	81	7	on	on	ADP
biomedich-731	81	8	the	the	DET
biomedich-731	81	9	enzyme	enzyme	NOUN
biomedich-731	81	10	,	,	PUNCT
biomedich-731	81	11	such	such	ADJ
biomedich-731	81	12	as	as	ADP
biomedich-731	81	13	amino	amino	NOUN
biomedich-731	81	14	acids	acid	NOUN
biomedich-731	81	15	involved	involve	VERB
biomedich-731	81	16	in	in	ADP
biomedich-731	81	17	forming	form	VERB
biomedich-731	81	18	the	the	DET
biomedich-731	81	19	active	active	ADJ
biomedich-731	81	20	site	site	NOUN
biomedich-731	81	21	,	,	PUNCT
biomedich-731	81	22	leading	lead	VERB
biomedich-731	81	23	to	to	ADP
biomedich-731	81	24	the	the	DET
biomedich-731	81	25	inhibition	inhibition	NOUN
biomedich-731	81	26	of	of	ADP
biomedich-731	81	27	peptide	peptide	ADJ
biomedich-731	81	28	cleavage	cleavage	NOUN
biomedich-731	81	29	and	and	CCONJ
biomedich-731	81	30	regulation	regulation	NOUN
biomedich-731	81	31	of	of	ADP
biomedich-731	81	32	insulin	insulin	NOUN
biomedich-731	81	33	secretion	secretion	NOUN
biomedich-731	81	34	.	.	PUNCT
biomedich-731	82	1	furthermore	furthermore	ADV
biomedich-731	82	2	,	,	PUNCT
biomedich-731	82	3	the	the	DET
biomedich-731	82	4	interaction	interaction	NOUN
biomedich-731	82	5	analysis	analysis	NOUN
biomedich-731	82	6	indicates	indicate	VERB
biomedich-731	82	7	that	that	SCONJ
biomedich-731	82	8	4	4	NUM
biomedich-731	82	9	-	-	PUNCT
biomedich-731	82	10	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	82	11	forms	form	NOUN
biomedich-731	82	12	several	several	ADJ
biomedich-731	82	13	hydrogen	hydrogen	NOUN
biomedich-731	82	14	bonds	bond	NOUN
biomedich-731	82	15	and	and	CCONJ
biomedich-731	82	16	hydrophobic	hydrophobic	NOUN
biomedich-731	82	17	interactions	interaction	NOUN
biomedich-731	82	18	with	with	ADP
biomedich-731	82	19	critical	critical	ADJ
biomedich-731	82	20	residues	residue	NOUN
biomedich-731	82	21	in	in	ADP
biomedich-731	82	22	dpp-4	dpp-4	ADJ
biomedich-731	82	23	.	.	PUNCT
biomedich-731	83	1	these	these	DET
biomedich-731	83	2	interactions	interaction	NOUN
biomedich-731	83	3	support	support	VERB
biomedich-731	83	4	the	the	DET
biomedich-731	83	5	stability	stability	NOUN
biomedich-731	83	6	of	of	ADP
biomedich-731	83	7	the	the	DET
biomedich-731	83	8	ligandenzyme	ligandenzyme	NOUN
biomedich-731	83	9	complex	complex	NOUN
biomedich-731	83	10	and	and	CCONJ
biomedich-731	83	11	enhance	enhance	VERB
biomedich-731	83	12	the	the	DET
biomedich-731	83	13	compound	compound	NOUN
biomedich-731	83	14	's	's	PART
biomedich-731	83	15	potential	potential	NOUN
biomedich-731	83	16	in	in	ADP
biomedich-731	83	17	inhibiting	inhibit	VERB
biomedich-731	83	18	dpp-4	dpp-4	ADJ
biomedich-731	83	19	activity	activity	NOUN
biomedich-731	83	20	.	.	PUNCT
biomedich-731	84	1	a	a	DET
biomedich-731	84	2	comparison	comparison	NOUN
biomedich-731	84	3	with	with	ADP
biomedich-731	84	4	conventional	conventional	ADJ
biomedich-731	84	5	dpp-4	dpp-4	ADJ
biomedich-731	84	6	inhibitors	inhibitor	NOUN
biomedich-731	84	7	,	,	PUNCT
biomedich-731	84	8	such	such	ADJ
biomedich-731	84	9	as	as	ADP
biomedich-731	84	10	sitagliptin	sitagliptin	NOUN
biomedich-731	84	11	,	,	PUNCT
biomedich-731	84	12	shows	show	VERB
biomedich-731	84	13	that	that	SCONJ
biomedich-731	84	14	4	4	NUM
biomedich-731	84	15	-	-	PUNCT
biomedich-731	84	16	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	84	17	has	have	VERB
biomedich-731	84	18	similar	similar	ADJ
biomedich-731	84	19	potential	potential	NOUN
biomedich-731	84	20	in	in	ADP
biomedich-731	84	21	binding	bind	VERB
biomedich-731	84	22	to	to	ADP
biomedich-731	84	23	the	the	DET
biomedich-731	84	24	enzyme	enzyme	NOUN
biomedich-731	84	25	's	's	PART
biomedich-731	84	26	active	active	ADJ
biomedich-731	84	27	site	site	NOUN
biomedich-731	84	28	,	,	PUNCT
biomedich-731	84	29	although	although	SCONJ
biomedich-731	84	30	with	with	ADP
biomedich-731	84	31	slightly	slightly	ADV
biomedich-731	84	32	different	different	ADJ
biomedich-731	84	33	binding	bind	VERB
biomedich-731	84	34	mechanisms	mechanism	NOUN
biomedich-731	84	35	.	.	PUNCT
biomedich-731	85	1	the	the	DET
biomedich-731	85	2	conclusions	conclusion	NOUN
biomedich-731	85	3	from	from	ADP
biomedich-731	85	4	these	these	DET
biomedich-731	85	5	docking	docking	NOUN
biomedich-731	85	6	results	result	NOUN
biomedich-731	85	7	suggest	suggest	VERB
biomedich-731	85	8	that	that	SCONJ
biomedich-731	85	9	4	4	NUM
biomedich-731	85	10	-	-	PUNCT
biomedich-731	85	11	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	85	12	has	have	VERB
biomedich-731	85	13	the	the	DET
biomedich-731	85	14	potential	potential	NOUN
biomedich-731	85	15	to	to	PART
biomedich-731	85	16	be	be	AUX
biomedich-731	85	17	an	an	DET
biomedich-731	85	18	effective	effective	ADJ
biomedich-731	85	19	natural	natural	ADJ
biomedich-731	85	20	dpp-4	dpp-4	NUM
biomedich-731	85	21	inhibitor	inhibitor	NOUN
biomedich-731	85	22	,	,	PUNCT
biomedich-731	85	23	which	which	PRON
biomedich-731	85	24	could	could	AUX
biomedich-731	85	25	contribute	contribute	VERB
biomedich-731	85	26	to	to	ADP
biomedich-731	85	27	the	the	DET
biomedich-731	85	28	control	control	NOUN
biomedich-731	85	29	of	of	ADP
biomedich-731	85	30	blood	blood	NOUN
biomedich-731	85	31	glucose	glucose	NOUN
biomedich-731	85	32	levels	level	NOUN
biomedich-731	85	33	.	.	PUNCT
biomedich-731	86	1	its	its	PRON
biomedich-731	86	2	strong	strong	ADJ
biomedich-731	86	3	and	and	CCONJ
biomedich-731	86	4	stable	stable	ADJ
biomedich-731	86	5	interaction	interaction	NOUN
biomedich-731	86	6	with	with	ADP
biomedich-731	86	7	the	the	DET
biomedich-731	86	8	dpp-4	dpp-4	ADV
biomedich-731	86	9	active	active	ADJ
biomedich-731	86	10	site	site	NOUN
biomedich-731	86	11	makes	make	VERB
biomedich-731	86	12	it	it	PRON
biomedich-731	86	13	a	a	DET
biomedich-731	86	14	promising	promising	ADJ
biomedich-731	86	15	candidate	candidate	NOUN
biomedich-731	86	16	for	for	ADP
biomedich-731	86	17	developing	develop	VERB
biomedich-731	86	18	natural	natural	ADJ
biomedich-731	86	19	-	-	PUNCT
biomedich-731	86	20	based	base	VERB
biomedich-731	86	21	antidiabetic	antidiabetic	ADJ
biomedich-731	86	22	drugs	drug	NOUN
biomedich-731	86	23	.	.	PUNCT
biomedich-731	87	1	these	these	DET
biomedich-731	87	2	findings	finding	NOUN
biomedich-731	87	3	pave	pave	VERB
biomedich-731	87	4	the	the	DET
biomedich-731	87	5	way	way	NOUN
biomedich-731	87	6	for	for	ADP
biomedich-731	87	7	further	further	ADJ
biomedich-731	87	8	research	research	NOUN
biomedich-731	87	9	,	,	PUNCT
biomedich-731	87	10	both	both	CCONJ
biomedich-731	87	11	in	in	ADP
biomedich-731	87	12	experimental	experimental	ADJ
biomedich-731	87	13	testing	testing	NOUN
biomedich-731	87	14	and	and	CCONJ
biomedich-731	87	15	the	the	DET
biomedich-731	87	16	development	development	NOUN
biomedich-731	87	17	of	of	ADP
biomedich-731	87	18	more	more	ADV
biomedich-731	87	19	effective	effective	ADJ
biomedich-731	87	20	and	and	CCONJ
biomedich-731	87	21	safe	safe	ADJ
biomedich-731	87	22	antidiabetic	antidiabetic	ADJ
biomedich-731	87	23	drug	drug	NOUN
biomedich-731	87	24	formulations	formulation	NOUN
biomedich-731	87	25	(	(	PUNCT
biomedich-731	87	26	setiawansyah	setiawansyah	NOUN
biomedich-731	87	27	et	et	PROPN
biomedich-731	87	28	al	al	PROPN
biomedich-731	87	29	.	.	PROPN
biomedich-731	87	30	,	,	PUNCT
biomedich-731	87	31	2022	2022	NUM
biomedich-731	87	32	)	)	PUNCT
biomedich-731	87	33	.	.	PUNCT
biomedich-731	88	1	post	post	ADJ
biomedich-731	88	2	-	-	ADJ
biomedich-731	88	3	docking	docking	ADJ
biomedich-731	88	4	analysis	analysis	NOUN
biomedich-731	88	5	post	post	ADJ
biomedich-731	88	6	-	-	ADJ
biomedich-731	88	7	docking	docking	ADJ
biomedich-731	88	8	visualization	visualization	NOUN
biomedich-731	88	9	confirmed	confirm	VERB
biomedich-731	88	10	significant	significant	ADJ
biomedich-731	88	11	interactions	interaction	NOUN
biomedich-731	88	12	between	between	ADP
biomedich-731	88	13	4	4	NUM
biomedich-731	88	14	-	-	PUNCT
biomedich-731	88	15	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	88	16	and	and	CCONJ
biomedich-731	88	17	active	active	ADJ
biomedich-731	88	18	site	site	NOUN
biomedich-731	88	19	residues	residue	NOUN
biomedich-731	88	20	of	of	ADP
biomedich-731	88	21	dpp4	dpp4	PROPN
biomedich-731	88	22	.	.	PUNCT
biomedich-731	89	1	key	key	ADJ
biomedich-731	89	2	hydrogen	hydrogen	NOUN
biomedich-731	89	3	bonds	bond	NOUN
biomedich-731	89	4	and	and	CCONJ
biomedich-731	89	5	hydrophobic	hydrophobic	NOUN
biomedich-731	89	6	interactions	interaction	NOUN
biomedich-731	89	7	were	be	AUX
biomedich-731	89	8	observed	observe	VERB
biomedich-731	89	9	,	,	PUNCT
biomedich-731	89	10	highlighting	highlight	VERB
biomedich-731	89	11	the	the	DET
biomedich-731	89	12	stability	stability	NOUN
biomedich-731	89	13	of	of	ADP
biomedich-731	89	14	the	the	DET
biomedich-731	89	15	4	4	NUM
biomedich-731	89	16	-	-	PUNCT
biomedich-731	89	17	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	89	18	-	-	PUNCT
biomedich-731	89	19	dpp4	dpp4	PROPN
biomedich-731	89	20	complex	complex	NOUN
biomedich-731	89	21	.	.	PUNCT
biomedich-731	90	1	these	these	DET
biomedich-731	90	2	interactions	interaction	NOUN
biomedich-731	90	3	contribute	contribute	VERB
biomedich-731	90	4	to	to	ADP
biomedich-731	90	5	the	the	DET
biomedich-731	90	6	compound	compound	NOUN
biomedich-731	90	7	’s	’s	PART
biomedich-731	90	8	binding	bind	VERB
biomedich-731	90	9	stability	stability	NOUN
biomedich-731	90	10	and	and	CCONJ
biomedich-731	90	11	reinforce	reinforce	VERB
biomedich-731	90	12	its	its	PRON
biomedich-731	90	13	potential	potential	ADJ
biomedich-731	90	14	efficacy	efficacy	NOUN
biomedich-731	90	15	in	in	ADP
biomedich-731	90	16	inhibiting	inhibit	VERB
biomedich-731	90	17	dpp4	dpp4	NOUN
biomedich-731	90	18	activity	activity	NOUN
biomedich-731	90	19	.	.	PUNCT
biomedich-731	91	1	figure	figure	NOUN
biomedich-731	91	2	3	3	NUM
biomedich-731	91	3	.	.	PUNCT
biomedich-731	92	1	visualization	visualization	NOUN
biomedich-731	92	2	of	of	ADP
biomedich-731	92	3	molecular	molecular	ADJ
biomedich-731	92	4	docking	docking	NOUN
biomedich-731	92	5	of	of	ADP
biomedich-731	92	6	ligands	ligand	NOUN
biomedich-731	92	7	and	and	CCONJ
biomedich-731	92	8	protein	protein	NOUN
biomedich-731	92	9	.	.	PUNCT
biomedich-731	93	1	(	(	PUNCT
biomedich-731	93	2	a	a	X
biomedich-731	93	3	)	)	PUNCT
biomedich-731	93	4	4	4	NUM
biomedich-731	93	5	-	-	NOUN
biomedich-731	93	6	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	93	7	,	,	PUNCT
biomedich-731	93	8	(	(	PUNCT
biomedich-731	93	9	b	b	NOUN
biomedich-731	93	10	)	)	PUNCT
biomedich-731	93	11	alogliptin	alogliptin	NOUN
biomedich-731	93	12	,	,	PUNCT
biomedich-731	93	13	(	(	PUNCT
biomedich-731	93	14	c	c	X
biomedich-731	93	15	)	)	PUNCT
biomedich-731	93	16	linagliptin	linagliptin	ADJ
biomedich-731	93	17	,	,	PUNCT
biomedich-731	93	18	(	(	PUNCT
biomedich-731	93	19	d	d	NOUN
biomedich-731	93	20	)	)	PUNCT
biomedich-731	93	21	sitagliptin	sitagliptin	NOUN
biomedich-731	93	22	,	,	PUNCT
biomedich-731	93	23	(	(	PUNCT
biomedich-731	93	24	e	e	NOUN
biomedich-731	93	25	)	)	PUNCT
biomedich-731	93	26	vildagliptin	vildagliptin	NOUN
biomedich-731	93	27	,	,	PUNCT
biomedich-731	93	28	(	(	PUNCT
biomedich-731	93	29	f	f	X
biomedich-731	93	30	)	)	PUNCT
biomedich-731	93	31	saxagliptin	saxagliptin	NOUN
biomedich-731	93	32	.	.	PUNCT
biomedich-731	94	1	comparison	comparison	NOUN
biomedich-731	94	2	with	with	ADP
biomedich-731	94	3	synthetic	synthetic	ADJ
biomedich-731	94	4	dpp4	dpp4	NOUN
biomedich-731	94	5	inhibitors	inhibitor	NOUN
biomedich-731	94	6	the	the	DET
biomedich-731	94	7	comparison	comparison	NOUN
biomedich-731	94	8	between	between	ADP
biomedich-731	94	9	4	4	NUM
biomedich-731	94	10	-	-	PUNCT
biomedich-731	94	11	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	94	12	and	and	CCONJ
biomedich-731	94	13	several	several	ADJ
biomedich-731	94	14	synthetic	synthetic	ADJ
biomedich-731	94	15	dpp-4	dpp-4	PUNCT
biomedich-731	94	16	inhibitors	inhibitor	NOUN
biomedich-731	94	17	reveals	reveal	VERB
biomedich-731	94	18	significant	significant	ADJ
biomedich-731	94	19	differences	difference	NOUN
biomedich-731	94	20	in	in	ADP
biomedich-731	94	21	their	their	PRON
biomedich-731	94	22	molecular	molecular	ADJ
biomedich-731	94	23	properties	property	NOUN
biomedich-731	94	24	and	and	CCONJ
biomedich-731	94	25	binding	bind	VERB
biomedich-731	94	26	affinities	affinity	NOUN
biomedich-731	94	27	.	.	PUNCT
biomedich-731	95	1	4	4	NUM
biomedich-731	95	2	-	-	PUNCT
biomedich-731	95	3	hydroxyisoleucine	hydroxyisoleucine	PROPN
biomedich-731	95	4	has	have	VERB
biomedich-731	95	5	a	a	DET
biomedich-731	95	6	molecular	molecular	ADJ
biomedich-731	95	7	weight	weight	NOUN
biomedich-731	95	8	of	of	ADP
biomedich-731	95	9	147.17	147.17	NUM
biomedich-731	95	10	g	g	NOUN
biomedich-731	95	11	/	/	SYM
biomedich-731	95	12	mol	mol	NOUN
biomedich-731	95	13	,	,	PUNCT
biomedich-731	95	14	which	which	PRON
biomedich-731	95	15	is	be	AUX
biomedich-731	95	16	notably	notably	ADV
biomedich-731	95	17	lower	low	ADJ
biomedich-731	95	18	than	than	ADP
biomedich-731	95	19	that	that	PRON
biomedich-731	95	20	of	of	ADP
biomedich-731	95	21	synthetic	synthetic	ADJ
biomedich-731	95	22	dpp-4	dpp-4	ADJ
biomedich-731	95	23	inhibitors	inhibitor	NOUN
biomedich-731	95	24	such	such	ADJ
biomedich-731	95	25	as	as	ADP
biomedich-731	95	26	linagliptin	linagliptin	ADJ
biomedich-731	95	27	(	(	PUNCT
biomedich-731	95	28	472.54	472.54	NUM
biomedich-731	95	29	g	g	NOUN
biomedich-731	95	30	/	/	SYM
biomedich-731	95	31	mol	mol	NOUN
biomedich-731	95	32	)	)	PUNCT
biomedich-731	95	33	and	and	CCONJ
biomedich-731	95	34	sitagliptin	sitagliptin	NOUN
biomedich-731	95	35	(	(	PUNCT
biomedich-731	95	36	407.31	407.31	NUM
biomedich-731	95	37	g	g	NOUN
biomedich-731	95	38	/	/	SYM
biomedich-731	95	39	mol	mol	NOUN
biomedich-731	95	40	)	)	PUNCT
biomedich-731	95	41	.	.	PUNCT
biomedich-731	96	1	this	this	DET
biomedich-731	96	2	difference	difference	NOUN
biomedich-731	96	3	in	in	ADP
biomedich-731	96	4	molecular	molecular	ADJ
biomedich-731	96	5	weight	weight	NOUN
biomedich-731	96	6	could	could	AUX
biomedich-731	96	7	influence	influence	VERB
biomedich-731	96	8	the	the	DET
biomedich-731	96	9	pharmacokinetics	pharmacokinetic	NOUN
biomedich-731	96	10	and	and	CCONJ
biomedich-731	96	11	drug	drug	NOUN
biomedich-731	96	12	-	-	PUNCT
biomedich-731	96	13	like	like	ADJ
biomedich-731	96	14	properties	property	NOUN
biomedich-731	96	15	of	of	ADP
biomedich-731	96	16	the	the	DET
biomedich-731	96	17	compounds	compound	NOUN
biomedich-731	96	18	,	,	PUNCT
biomedich-731	96	19	with	with	ADP
biomedich-731	96	20	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	96	21	's	's	PART
biomedich-731	96	22	smaller	small	ADJ
biomedich-731	96	23	size	size	NOUN
biomedich-731	96	24	potentially	potentially	ADV
biomedich-731	96	25	offering	offer	VERB
biomedich-731	96	26	advantages	advantage	NOUN
biomedich-731	96	27	such	such	ADJ
biomedich-731	96	28	as	as	ADP
biomedich-731	96	29	better	well	ADJ
biomedich-731	96	30	oral	oral	ADJ
biomedich-731	96	31	bioavailability	bioavailability	NOUN
biomedich-731	96	32	and	and	CCONJ
biomedich-731	96	33	metabolic	metabolic	NOUN
biomedich-731	96	34	stability	stability	NOUN
biomedich-731	96	35	.	.	PUNCT
biomedich-731	97	1	furthermore	furthermore	ADV
biomedich-731	97	2	,	,	PUNCT
biomedich-731	97	3	4	4	X
biomedich-731	97	4	-	-	NOUN
biomedich-731	97	5	hydroxyisoleucine	hydroxyisoleucine	PROPN
biomedich-731	97	6	has	have	VERB
biomedich-731	97	7	a	a	DET
biomedich-731	97	8	binding	bind	VERB
biomedich-731	97	9	affinity	affinity	NOUN
biomedich-731	97	10	of	of	ADP
biomedich-731	97	11	-5.0	-5.0	X
biomedich-731	97	12	kcal	kcal	PROPN
biomedich-731	97	13	/	/	SYM
biomedich-731	97	14	mol	mol	PROPN
biomedich-731	97	15	,	,	PUNCT
biomedich-731	97	16	which	which	PRON
biomedich-731	97	17	is	be	AUX
biomedich-731	97	18	lower	low	ADJ
biomedich-731	97	19	compared	compare	VERB
biomedich-731	97	20	to	to	ADP
biomedich-731	97	21	the	the	DET
biomedich-731	97	22	more	more	ADV
biomedich-731	97	23	potent	potent	ADJ
biomedich-731	97	24	synthetic	synthetic	ADJ
biomedich-731	97	25	inhibitors	inhibitor	NOUN
biomedich-731	97	26	,	,	PUNCT
biomedich-731	97	27	with	with	ADP
biomedich-731	97	28	linagliptin	linagliptin	ADJ
biomedich-731	97	29	showing	show	VERB
biomedich-731	97	30	the	the	DET
biomedich-731	97	31	highest	high	ADJ
biomedich-731	97	32	affinity	affinity	NOUN
biomedich-731	97	33	at	at	ADP
biomedich-731	97	34	-8.7	-8.7	PUNCT
biomedich-731	97	35	kcal	kcal	NOUN
biomedich-731	97	36	/	/	SYM
biomedich-731	97	37	mol	mol	PROPN
biomedich-731	97	38	,	,	PUNCT
biomedich-731	97	39	followed	follow	VERB
biomedich-731	97	40	by	by	ADP
biomedich-731	97	41	sitagliptin	sitagliptin	NOUN
biomedich-731	97	42	at	at	ADP
biomedich-731	97	43	-8.0	-8.0	PROPN
biomedich-731	97	44	kcal	kcal	NOUN
biomedich-731	97	45	/	/	SYM
biomedich-731	97	46	mol	mol	PROPN
biomedich-731	97	47	and	and	CCONJ
biomedich-731	97	48	saxagliptin	saxagliptin	NOUN
biomedich-731	97	49	at	at	ADP
biomedich-731	97	50	-6.8	-6.8	PROPN
biomedich-731	97	51	thalib	thalib	PROPN
biomedich-731	97	52	&	&	CCONJ
biomedich-731	97	53	damayanti	damayanti	PROPN
biomedich-731	97	54	–	–	PUNCT
biomedich-731	97	55	4	4	NUM
biomedich-731	97	56	-	-	NOUN
biomedich-731	97	57	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	97	58	as	as	ADP
biomedich-731	97	59	a	a	DET
biomedich-731	97	60	natural	natural	ADJ
biomedich-731	97	61	dpp-4	dpp-4	ADJ
biomedich-731	97	62	inhibitor	inhibitor	NOUN
biomedich-731	97	63	for	for	ADP
biomedich-731	97	64	diabetes	diabetes	NOUN
biomedich-731	97	65	413	413	NUM
biomedich-731	97	66	kcal	kcal	NOUN
biomedich-731	97	67	/	/	SYM
biomedich-731	97	68	mol	mol	PROPN
biomedich-731	97	69	.	.	PUNCT
biomedich-731	98	1	these	these	DET
biomedich-731	98	2	findings	finding	NOUN
biomedich-731	98	3	suggest	suggest	VERB
biomedich-731	98	4	that	that	SCONJ
biomedich-731	98	5	synthetic	synthetic	ADJ
biomedich-731	98	6	inhibitors	inhibitor	NOUN
biomedich-731	98	7	typically	typically	ADV
biomedich-731	98	8	interact	interact	VERB
biomedich-731	98	9	more	more	ADV
biomedich-731	98	10	with	with	ADP
biomedich-731	99	1	the	the	DET
biomedich-731	99	2	dpp-4	dpp-4	ADJ
biomedich-731	99	3	enzyme	enzyme	NOUN
biomedich-731	99	4	,	,	PUNCT
biomedich-731	99	5	potentially	potentially	ADV
biomedich-731	99	6	contributing	contribute	VERB
biomedich-731	99	7	to	to	ADP
biomedich-731	99	8	their	their	PRON
biomedich-731	99	9	higher	high	ADJ
biomedich-731	99	10	potency	potency	NOUN
biomedich-731	99	11	in	in	ADP
biomedich-731	99	12	enzyme	enzyme	NOUN
biomedich-731	99	13	inhibition	inhibition	NOUN
biomedich-731	99	14	.	.	PUNCT
biomedich-731	100	1	the	the	DET
biomedich-731	100	2	molecular	molecular	ADJ
biomedich-731	100	3	formulas	formula	NOUN
biomedich-731	100	4	of	of	ADP
biomedich-731	100	5	these	these	DET
biomedich-731	100	6	compounds	compound	NOUN
biomedich-731	100	7	also	also	ADV
biomedich-731	100	8	show	show	VERB
biomedich-731	100	9	notable	notable	ADJ
biomedich-731	100	10	differences	difference	NOUN
biomedich-731	100	11	,	,	PUNCT
biomedich-731	100	12	with	with	ADP
biomedich-731	100	13	synthetic	synthetic	ADJ
biomedich-731	100	14	inhibitors	inhibitor	NOUN
biomedich-731	100	15	having	have	VERB
biomedich-731	100	16	more	more	ADJ
biomedich-731	100	17	complex	complex	ADJ
biomedich-731	100	18	structures	structure	NOUN
biomedich-731	100	19	featuring	feature	VERB
biomedich-731	100	20	larger	large	ADJ
biomedich-731	100	21	carbon	carbon	NOUN
biomedich-731	100	22	chains	chain	NOUN
biomedich-731	100	23	and	and	CCONJ
biomedich-731	100	24	additional	additional	ADJ
biomedich-731	100	25	functional	functional	ADJ
biomedich-731	100	26	groups	group	NOUN
biomedich-731	100	27	,	,	PUNCT
biomedich-731	100	28	whereas	whereas	SCONJ
biomedich-731	100	29	4	4	NUM
biomedich-731	100	30	-	-	NOUN
biomedich-731	100	31	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	100	32	has	have	VERB
biomedich-731	100	33	a	a	DET
biomedich-731	100	34	simpler	simple	ADJ
biomedich-731	100	35	structure	structure	NOUN
biomedich-731	100	36	(	(	PUNCT
biomedich-731	100	37	c6h13no3	c6h13no3	NOUN
biomedich-731	100	38	)	)	PUNCT
biomedich-731	100	39	.	.	PUNCT
biomedich-731	101	1	despite	despite	SCONJ
biomedich-731	101	2	the	the	DET
biomedich-731	101	3	lower	low	ADJ
biomedich-731	101	4	binding	bind	VERB
biomedich-731	101	5	affinity	affinity	NOUN
biomedich-731	101	6	of	of	ADP
biomedich-731	101	7	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	101	8	,	,	PUNCT
biomedich-731	101	9	its	its	PRON
biomedich-731	101	10	natural	natural	ADJ
biomedich-731	101	11	origin	origin	NOUN
biomedich-731	101	12	,	,	PUNCT
biomedich-731	101	13	simpler	simple	ADJ
biomedich-731	101	14	structure	structure	NOUN
biomedich-731	101	15	,	,	PUNCT
biomedich-731	101	16	and	and	CCONJ
biomedich-731	101	17	smaller	small	ADJ
biomedich-731	101	18	size	size	NOUN
biomedich-731	101	19	make	make	VERB
biomedich-731	101	20	it	it	PRON
biomedich-731	101	21	a	a	DET
biomedich-731	101	22	promising	promising	ADJ
biomedich-731	101	23	candidate	candidate	NOUN
biomedich-731	101	24	for	for	ADP
biomedich-731	101	25	further	further	ADJ
biomedich-731	101	26	research	research	NOUN
biomedich-731	101	27	as	as	ADP
biomedich-731	101	28	a	a	DET
biomedich-731	101	29	natural	natural	ADJ
biomedich-731	101	30	-	-	PUNCT
biomedich-731	101	31	based	base	VERB
biomedich-731	101	32	antidiabetic	antidiabetic	ADJ
biomedich-731	101	33	agent	agent	NOUN
biomedich-731	101	34	.	.	PUNCT
biomedich-731	102	1	the	the	DET
biomedich-731	102	2	lower	lower	ADV
biomedich-731	102	3	binding	bind	VERB
biomedich-731	102	4	affinity	affinity	NOUN
biomedich-731	102	5	does	do	AUX
biomedich-731	102	6	not	not	PART
biomedich-731	102	7	diminish	diminish	VERB
biomedich-731	102	8	its	its	PRON
biomedich-731	102	9	potential	potential	ADJ
biomedich-731	102	10	efficacy	efficacy	NOUN
biomedich-731	102	11	,	,	PUNCT
biomedich-731	102	12	especially	especially	ADV
biomedich-731	102	13	if	if	SCONJ
biomedich-731	102	14	it	it	PRON
biomedich-731	102	15	can	can	AUX
biomedich-731	102	16	offer	offer	VERB
biomedich-731	102	17	other	other	ADJ
biomedich-731	102	18	benefits	benefit	NOUN
biomedich-731	102	19	such	such	ADJ
biomedich-731	102	20	as	as	ADP
biomedich-731	102	21	a	a	DET
biomedich-731	102	22	better	well	ADJ
biomedich-731	102	23	safety	safety	NOUN
biomedich-731	102	24	profile	profile	NOUN
biomedich-731	102	25	,	,	PUNCT
biomedich-731	102	26	fewer	few	ADJ
biomedich-731	102	27	side	side	NOUN
biomedich-731	102	28	effects	effect	NOUN
biomedich-731	102	29	,	,	PUNCT
biomedich-731	102	30	and	and	CCONJ
biomedich-731	102	31	possible	possible	ADJ
biomedich-731	102	32	synergistic	synergistic	ADJ
biomedich-731	102	33	effects	effect	NOUN
biomedich-731	102	34	when	when	SCONJ
biomedich-731	102	35	used	use	VERB
biomedich-731	102	36	in	in	ADP
biomedich-731	102	37	combination	combination	NOUN
biomedich-731	102	38	therapies	therapy	NOUN
biomedich-731	102	39	.	.	PUNCT
biomedich-731	103	1	future	future	ADJ
biomedich-731	103	2	research	research	NOUN
biomedich-731	103	3	is	be	AUX
biomedich-731	103	4	needed	need	VERB
biomedich-731	103	5	to	to	PART
biomedich-731	103	6	explore	explore	VERB
biomedich-731	103	7	the	the	DET
biomedich-731	103	8	practical	practical	ADJ
biomedich-731	103	9	therapeutic	therapeutic	ADJ
biomedich-731	103	10	applications	application	NOUN
biomedich-731	103	11	of	of	ADP
biomedich-731	103	12	4	4	NUM
biomedich-731	103	13	-	-	PUNCT
biomedich-731	103	14	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	103	15	in	in	ADP
biomedich-731	103	16	diabetes	diabetes	NOUN
biomedich-731	103	17	management	management	NOUN
biomedich-731	103	18	and	and	CCONJ
biomedich-731	103	19	its	its	PRON
biomedich-731	103	20	potential	potential	NOUN
biomedich-731	103	21	as	as	ADP
biomedich-731	103	22	an	an	DET
biomedich-731	103	23	alternative	alternative	NOUN
biomedich-731	103	24	to	to	PART
biomedich-731	103	25	synthetic	synthetic	VERB
biomedich-731	103	26	dpp-4	dpp-4	PRON
biomedich-731	103	27	inhibitors	inhibitor	NOUN
biomedich-731	103	28	.	.	PUNCT
biomedich-731	104	1	ligands	ligand	NOUN
biomedich-731	104	2	cid	cid	VERB
biomedich-731	104	3	molecular	molecular	ADJ
biomedich-731	104	4	formula	formula	NOUN
biomedich-731	104	5	molecular	molecular	ADJ
biomedich-731	104	6	weight	weight	NOUN
biomedich-731	104	7	(	(	PUNCT
biomedich-731	104	8	g	g	NOUN
biomedich-731	104	9	/	/	SYM
biomedich-731	104	10	mol	mol	NOUN
biomedich-731	104	11	)	)	PUNCT
biomedich-731	104	12	binding	bind	VERB
biomedich-731	104	13	affinity	affinity	NOUN
biomedich-731	104	14	(	(	PUNCT
biomedich-731	104	15	kcal	kcal	NOUN
biomedich-731	104	16	/	/	SYM
biomedich-731	104	17	mol	mol	NOUN
biomedich-731	104	18	)	)	PUNCT
biomedich-731	104	19	4	4	NUM
biomedich-731	104	20	-	-	PUNCT
biomedich-731	104	21	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	104	22	2773624	2773624	NUM
biomedich-731	104	23	c6h13no3	c6h13no3	PROPN
biomedich-731	104	24	147.17	147.17	NUM
biomedich-731	104	25	-5,0	-5,0	PROPN
biomedich-731	104	26	alogliptin	alogliptin	NOUN
biomedich-731	104	27	10244493	10244493	NUM
biomedich-731	104	28	c18h21n5o2s	c18h21n5o2s	PROPN
biomedich-731	105	1	339,45	339,45	NUM
biomedich-731	105	2	-6,6	-6,6	PUNCT
biomedich-731	106	1	linagliptin	linagliptin	PROPN
biomedich-731	106	2	10096344	10096344	NUM
biomedich-731	106	3	c25h28n8o2	c25h28n8o2	PROPN
biomedich-731	106	4	472,54	472,54	PROPN
biomedich-731	106	5	-8,7	-8,7	CCONJ
biomedich-731	106	6	saxagliptin	saxagliptin	NOUN
biomedich-731	106	7	11235634	11235634	NUM
biomedich-731	106	8	c18h25n3o2	c18h25n3o2	PROPN
biomedich-731	106	9	315,41	315,41	NUM
biomedich-731	106	10	-6,8	-6,8	NOUN
biomedich-731	106	11	sitagliptin	sitagliptin	NOUN
biomedich-731	106	12	4369359	4369359	NUM
biomedich-731	106	13	c16h15f6n5o	c16h15f6n5o	VERB
biomedich-731	106	14	407,31	407,31	NOUN
biomedich-731	106	15	-8,0	-8,0	NOUN
biomedich-731	106	16	vildagliptin	vildagliptin	NOUN
biomedich-731	106	17	6918586	6918586	NUM
biomedich-731	106	18	c17h25n3o2	c17h25n3o2	PROPN
biomedich-731	106	19	303,40	303,40	NUM
biomedich-731	106	20	-7,3	-7,3	NOUN
biomedich-731	106	21	adme	adme	NOUN
biomedich-731	106	22	and	and	CCONJ
biomedich-731	106	23	toxicity	toxicity	NOUN
biomedich-731	106	24	profile	profile	NOUN
biomedich-731	107	1	the	the	DET
biomedich-731	107	2	adme	adme	NOUN
biomedich-731	107	3	(	(	PUNCT
biomedich-731	107	4	absorption	absorption	NOUN
biomedich-731	107	5	,	,	PUNCT
biomedich-731	107	6	distribution	distribution	NOUN
biomedich-731	107	7	,	,	PUNCT
biomedich-731	107	8	metabolism	metabolism	NOUN
biomedich-731	107	9	,	,	PUNCT
biomedich-731	107	10	excretion	excretion	NOUN
biomedich-731	107	11	)	)	PUNCT
biomedich-731	107	12	and	and	CCONJ
biomedich-731	107	13	toxicity	toxicity	NOUN
biomedich-731	107	14	profile	profile	NOUN
biomedich-731	107	15	of	of	ADP
biomedich-731	107	16	4	4	NUM
biomedich-731	107	17	-	-	PUNCT
biomedich-731	107	18	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	107	19	were	be	AUX
biomedich-731	107	20	evaluated	evaluate	VERB
biomedich-731	107	21	to	to	PART
biomedich-731	107	22	assess	assess	VERB
biomedich-731	107	23	its	its	PRON
biomedich-731	107	24	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	107	25	properties	property	NOUN
biomedich-731	107	26	and	and	CCONJ
biomedich-731	107	27	safety	safety	NOUN
biomedich-731	107	28	as	as	ADP
biomedich-731	107	29	a	a	DET
biomedich-731	107	30	potential	potential	ADJ
biomedich-731	107	31	therapeutic	therapeutic	ADJ
biomedich-731	107	32	agent	agent	NOUN
biomedich-731	107	33	.	.	PUNCT
biomedich-731	108	1	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	108	2	demonstrated	demonstrate	VERB
biomedich-731	108	3	high	high	ADJ
biomedich-731	108	4	gastrointestinal	gastrointestinal	ADJ
biomedich-731	108	5	absorption	absorption	NOUN
biomedich-731	108	6	,	,	PUNCT
biomedich-731	108	7	indicating	indicate	VERB
biomedich-731	108	8	that	that	SCONJ
biomedich-731	108	9	the	the	DET
biomedich-731	108	10	compound	compound	NOUN
biomedich-731	108	11	can	can	AUX
biomedich-731	108	12	be	be	AUX
biomedich-731	108	13	efficiently	efficiently	ADV
biomedich-731	108	14	absorbed	absorb	VERB
biomedich-731	108	15	into	into	ADP
biomedich-731	108	16	the	the	DET
biomedich-731	108	17	bloodstream	bloodstream	NOUN
biomedich-731	108	18	orally	orally	ADV
biomedich-731	108	19	,	,	PUNCT
biomedich-731	108	20	making	make	VERB
biomedich-731	108	21	it	it	PRON
biomedich-731	108	22	a	a	DET
biomedich-731	108	23	suitable	suitable	ADJ
biomedich-731	108	24	candidate	candidate	NOUN
biomedich-731	108	25	for	for	ADP
biomedich-731	108	26	oral	oral	ADJ
biomedich-731	108	27	drug	drug	NOUN
biomedich-731	108	28	formulations	formulation	NOUN
biomedich-731	108	29	.	.	PUNCT
biomedich-731	109	1	additionally	additionally	ADV
biomedich-731	109	2	,	,	PUNCT
biomedich-731	109	3	the	the	DET
biomedich-731	109	4	compound	compound	NOUN
biomedich-731	109	5	showed	show	VERB
biomedich-731	109	6	moderate	moderate	ADJ
biomedich-731	109	7	water	water	NOUN
biomedich-731	109	8	solubility	solubility	NOUN
biomedich-731	109	9	,	,	PUNCT
biomedich-731	109	10	which	which	PRON
biomedich-731	109	11	enhances	enhance	VERB
biomedich-731	109	12	its	its	PRON
biomedich-731	109	13	potential	potential	NOUN
biomedich-731	109	14	for	for	ADP
biomedich-731	109	15	distribution	distribution	NOUN
biomedich-731	109	16	throughout	throughout	ADP
biomedich-731	109	17	the	the	DET
biomedich-731	109	18	body	body	NOUN
biomedich-731	109	19	.	.	PUNCT
biomedich-731	110	1	however	however	ADV
biomedich-731	110	2	,	,	PUNCT
biomedich-731	110	3	it	it	PRON
biomedich-731	110	4	exhibited	exhibit	VERB
biomedich-731	110	5	limited	limited	ADJ
biomedich-731	110	6	penetration	penetration	NOUN
biomedich-731	110	7	across	across	ADP
biomedich-731	110	8	the	the	DET
biomedich-731	110	9	blood	blood	NOUN
biomedich-731	110	10	-	-	PUNCT
biomedich-731	110	11	brain	brain	NOUN
biomedich-731	110	12	barrier	barrier	NOUN
biomedich-731	110	13	(	(	PUNCT
biomedich-731	110	14	bbb	bbb	PROPN
biomedich-731	110	15	)	)	PUNCT
biomedich-731	110	16	,	,	PUNCT
biomedich-731	110	17	which	which	PRON
biomedich-731	110	18	reduces	reduce	VERB
biomedich-731	110	19	the	the	DET
biomedich-731	110	20	risk	risk	NOUN
biomedich-731	110	21	of	of	ADP
biomedich-731	110	22	central	central	ADJ
biomedich-731	110	23	nervous	nervous	ADJ
biomedich-731	110	24	system	system	NOUN
biomedich-731	110	25	side	side	NOUN
biomedich-731	110	26	effects	effect	NOUN
biomedich-731	110	27	,	,	PUNCT
biomedich-731	110	28	helping	help	VERB
biomedich-731	110	29	to	to	PART
biomedich-731	110	30	target	target	VERB
biomedich-731	110	31	peripheral	peripheral	ADJ
biomedich-731	110	32	tissues	tissue	NOUN
biomedich-731	110	33	without	without	ADP
biomedich-731	110	34	affecting	affect	VERB
biomedich-731	110	35	brain	brain	NOUN
biomedich-731	110	36	function	function	NOUN
biomedich-731	110	37	.	.	PUNCT
biomedich-731	111	1	predictions	prediction	NOUN
biomedich-731	111	2	suggest	suggest	VERB
biomedich-731	111	3	that	that	SCONJ
biomedich-731	111	4	4	4	NUM
biomedich-731	111	5	-	-	NOUN
biomedich-731	111	6	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	111	7	does	do	AUX
biomedich-731	111	8	not	not	PART
biomedich-731	111	9	undergo	undergo	VERB
biomedich-731	111	10	extensive	extensive	ADJ
biomedich-731	111	11	metabolism	metabolism	NOUN
biomedich-731	111	12	,	,	PUNCT
biomedich-731	111	13	which	which	PRON
biomedich-731	111	14	implies	imply	VERB
biomedich-731	111	15	that	that	SCONJ
biomedich-731	111	16	it	it	PRON
biomedich-731	111	17	may	may	AUX
biomedich-731	111	18	retain	retain	VERB
biomedich-731	111	19	its	its	PRON
biomedich-731	111	20	bioactive	bioactive	ADJ
biomedich-731	111	21	form	form	NOUN
biomedich-731	111	22	for	for	ADP
biomedich-731	111	23	a	a	DET
biomedich-731	111	24	longer	long	ADJ
biomedich-731	111	25	duration	duration	NOUN
biomedich-731	111	26	in	in	ADP
biomedich-731	111	27	the	the	DET
biomedich-731	111	28	body	body	NOUN
biomedich-731	111	29	.	.	PUNCT
biomedich-731	112	1	this	this	DET
biomedich-731	112	2	characteristic	characteristic	NOUN
biomedich-731	112	3	could	could	AUX
biomedich-731	112	4	lead	lead	VERB
biomedich-731	112	5	to	to	ADP
biomedich-731	112	6	prolonged	prolonged	ADJ
biomedich-731	112	7	therapeutic	therapeutic	ADJ
biomedich-731	112	8	effects	effect	NOUN
biomedich-731	112	9	,	,	PUNCT
biomedich-731	112	10	as	as	SCONJ
biomedich-731	112	11	the	the	DET
biomedich-731	112	12	compound	compound	NOUN
biomedich-731	112	13	is	be	AUX
biomedich-731	112	14	less	less	ADV
biomedich-731	112	15	likely	likely	ADJ
biomedich-731	112	16	to	to	PART
biomedich-731	112	17	be	be	AUX
biomedich-731	112	18	rapidly	rapidly	ADV
biomedich-731	112	19	broken	break	VERB
biomedich-731	112	20	down	down	ADP
biomedich-731	112	21	by	by	ADP
biomedich-731	112	22	metabolic	metabolic	NOUN
biomedich-731	112	23	enzymes	enzyme	NOUN
biomedich-731	112	24	.	.	PUNCT
biomedich-731	113	1	furthermore	furthermore	ADV
biomedich-731	113	2	,	,	PUNCT
biomedich-731	113	3	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	113	4	is	be	AUX
biomedich-731	113	5	expected	expect	VERB
biomedich-731	113	6	to	to	PART
biomedich-731	113	7	be	be	AUX
biomedich-731	113	8	excreted	excrete	VERB
biomedich-731	113	9	primarily	primarily	ADV
biomedich-731	113	10	through	through	ADP
biomedich-731	113	11	the	the	DET
biomedich-731	113	12	urine	urine	NOUN
biomedich-731	113	13	,	,	PUNCT
biomedich-731	113	14	a	a	DET
biomedich-731	113	15	common	common	ADJ
biomedich-731	113	16	pathway	pathway	NOUN
biomedich-731	113	17	for	for	ADP
biomedich-731	113	18	small	small	ADJ
biomedich-731	113	19	molecules	molecule	NOUN
biomedich-731	113	20	with	with	ADP
biomedich-731	113	21	low	low	ADJ
biomedich-731	113	22	molecular	molecular	ADJ
biomedich-731	113	23	weight	weight	NOUN
biomedich-731	113	24	,	,	PUNCT
biomedich-731	113	25	emphasizing	emphasize	VERB
biomedich-731	113	26	the	the	DET
biomedich-731	113	27	importance	importance	NOUN
biomedich-731	113	28	of	of	ADP
biomedich-731	113	29	renal	renal	ADJ
biomedich-731	113	30	function	function	NOUN
biomedich-731	113	31	in	in	ADP
biomedich-731	113	32	eliminating	eliminate	VERB
biomedich-731	113	33	the	the	DET
biomedich-731	113	34	compound	compound	NOUN
biomedich-731	113	35	from	from	ADP
biomedich-731	113	36	the	the	DET
biomedich-731	113	37	body	body	NOUN
biomedich-731	113	38	.	.	PUNCT
biomedich-731	114	1	in	in	ADP
biomedich-731	114	2	terms	term	NOUN
biomedich-731	114	3	of	of	ADP
biomedich-731	114	4	toxicity	toxicity	NOUN
biomedich-731	114	5	,	,	PUNCT
biomedich-731	114	6	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	114	7	was	be	AUX
biomedich-731	114	8	predicted	predict	VERB
biomedich-731	114	9	to	to	PART
biomedich-731	114	10	have	have	VERB
biomedich-731	114	11	a	a	DET
biomedich-731	114	12	favorable	favorable	ADJ
biomedich-731	114	13	safety	safety	NOUN
biomedich-731	114	14	profile	profile	NOUN
biomedich-731	114	15	,	,	PUNCT
biomedich-731	114	16	associated	associate	VERB
biomedich-731	114	17	with	with	ADP
biomedich-731	114	18	low	low	ADJ
biomedich-731	114	19	hepatotoxicity	hepatotoxicity	NOUN
biomedich-731	114	20	,	,	PUNCT
biomedich-731	114	21	suggesting	suggest	VERB
biomedich-731	114	22	minimal	minimal	ADJ
biomedich-731	114	23	risk	risk	NOUN
biomedich-731	114	24	to	to	PART
biomedich-731	114	25	liver	liver	NOUN
biomedich-731	114	26	function	function	NOUN
biomedich-731	114	27	(	(	PUNCT
biomedich-731	114	28	setiawansyah	setiawansyah	NOUN
biomedich-731	114	29	et	et	PROPN
biomedich-731	114	30	al	al	PROPN
biomedich-731	114	31	.	.	PROPN
biomedich-731	114	32	,	,	PUNCT
biomedich-731	114	33	2022	2022	NUM
biomedich-731	114	34	)	)	PUNCT
biomedich-731	114	35	.	.	PUNCT
biomedich-731	115	1	it	it	PRON
biomedich-731	115	2	also	also	ADV
biomedich-731	115	3	did	do	AUX
biomedich-731	115	4	not	not	PART
biomedich-731	115	5	show	show	VERB
biomedich-731	115	6	signs	sign	NOUN
biomedich-731	115	7	of	of	ADP
biomedich-731	115	8	mutagenicity	mutagenicity	NOUN
biomedich-731	115	9	or	or	CCONJ
biomedich-731	115	10	carcinogenicity	carcinogenicity	NOUN
biomedich-731	115	11	,	,	PUNCT
biomedich-731	115	12	indicating	indicate	VERB
biomedich-731	115	13	that	that	SCONJ
biomedich-731	115	14	it	it	PRON
biomedich-731	115	15	is	be	AUX
biomedich-731	115	16	unlikely	unlikely	ADJ
biomedich-731	115	17	to	to	PART
biomedich-731	115	18	cause	cause	VERB
biomedich-731	115	19	genetic	genetic	ADJ
biomedich-731	115	20	mutations	mutation	NOUN
biomedich-731	115	21	or	or	CCONJ
biomedich-731	115	22	cancer	cancer	NOUN
biomedich-731	115	23	.	.	PUNCT
biomedich-731	116	1	with	with	ADP
biomedich-731	116	2	an	an	DET
biomedich-731	116	3	ld50	ld50	PROPN
biomedich-731	116	4	value	value	NOUN
biomedich-731	116	5	greater	great	ADJ
biomedich-731	116	6	than	than	ADP
biomedich-731	116	7	2000	2000	NUM
biomedich-731	116	8	mg	mg	PROPN
biomedich-731	116	9	/	/	SYM
biomedich-731	116	10	kg	kg	PROPN
biomedich-731	116	11	,	,	PUNCT
biomedich-731	116	12	4	4	NUM
biomedich-731	116	13	-	-	PUNCT
biomedich-731	116	14	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	116	15	falls	fall	VERB
biomedich-731	116	16	under	under	ADP
biomedich-731	116	17	toxicity	toxicity	NOUN
biomedich-731	116	18	class	class	NOUN
biomedich-731	116	19	5	5	NUM
biomedich-731	116	20	,	,	PUNCT
biomedich-731	116	21	classifying	classify	VERB
biomedich-731	116	22	it	it	PRON
biomedich-731	116	23	as	as	ADP
biomedich-731	116	24	a	a	DET
biomedich-731	116	25	low	low	ADJ
biomedich-731	116	26	-	-	PUNCT
biomedich-731	116	27	toxicity	toxicity	NOUN
biomedich-731	116	28	substance	substance	NOUN
biomedich-731	116	29	.	.	PUNCT
biomedich-731	117	1	this	this	DET
biomedich-731	117	2	further	far	ADV
biomedich-731	117	3	supports	support	VERB
biomedich-731	117	4	its	its	PRON
biomedich-731	117	5	safety	safety	NOUN
biomedich-731	117	6	for	for	ADP
biomedich-731	117	7	use	use	NOUN
biomedich-731	117	8	in	in	ADP
biomedich-731	117	9	therapeutic	therapeutic	ADJ
biomedich-731	117	10	applications	application	NOUN
biomedich-731	117	11	.	.	PUNCT
biomedich-731	118	1	in	in	ADP
biomedich-731	118	2	summary	summary	NOUN
biomedich-731	118	3	,	,	PUNCT
biomedich-731	118	4	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	118	5	exhibits	exhibit	VERB
biomedich-731	118	6	favorable	favorable	ADJ
biomedich-731	118	7	adme	adme	NOUN
biomedich-731	118	8	properties	property	NOUN
biomedich-731	118	9	,	,	PUNCT
biomedich-731	118	10	including	include	VERB
biomedich-731	118	11	high	high	ADJ
biomedich-731	118	12	oral	oral	ADJ
biomedich-731	118	13	bioavailability	bioavailability	NOUN
biomedich-731	118	14	,	,	PUNCT
biomedich-731	118	15	moderate	moderate	ADJ
biomedich-731	118	16	solubility	solubility	NOUN
biomedich-731	118	17	,	,	PUNCT
biomedich-731	118	18	and	and	CCONJ
biomedich-731	118	19	low	low	ADJ
biomedich-731	118	20	toxicity	toxicity	NOUN
biomedich-731	118	21	.	.	PUNCT
biomedich-731	119	1	these	these	DET
biomedich-731	119	2	characteristics	characteristic	NOUN
biomedich-731	119	3	make	make	VERB
biomedich-731	119	4	it	it	PRON
biomedich-731	119	5	a	a	DET
biomedich-731	119	6	promising	promising	ADJ
biomedich-731	119	7	candidate	candidate	NOUN
biomedich-731	119	8	for	for	ADP
biomedich-731	119	9	further	further	ADJ
biomedich-731	119	10	development	development	NOUN
biomedich-731	119	11	as	as	ADP
biomedich-731	119	12	a	a	DET
biomedich-731	119	13	natural	natural	ADJ
biomedich-731	119	14	therapeutic	therapeutic	ADJ
biomedich-731	119	15	agent	agent	NOUN
biomedich-731	119	16	,	,	PUNCT
biomedich-731	119	17	particularly	particularly	ADV
biomedich-731	119	18	for	for	ADP
biomedich-731	119	19	conditions	condition	NOUN
biomedich-731	119	20	like	like	ADP
biomedich-731	119	21	diabetes	diabetes	NOUN
biomedich-731	119	22	.	.	PUNCT
biomedich-731	120	1	the	the	DET
biomedich-731	120	2	compound	compound	NOUN
biomedich-731	120	3	's	's	PART
biomedich-731	120	4	excellent	excellent	ADJ
biomedich-731	120	5	safety	safety	NOUN
biomedich-731	120	6	profile	profile	NOUN
biomedich-731	120	7	and	and	CCONJ
biomedich-731	120	8	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	120	9	features	feature	NOUN
biomedich-731	120	10	position	position	VERB
biomedich-731	120	11	it	it	PRON
biomedich-731	120	12	as	as	ADP
biomedich-731	120	13	an	an	DET
biomedich-731	120	14	attractive	attractive	ADJ
biomedich-731	120	15	option	option	NOUN
biomedich-731	120	16	for	for	ADP
biomedich-731	120	17	future	future	ADJ
biomedich-731	120	18	drug	drug	NOUN
biomedich-731	120	19	development	development	NOUN
biomedich-731	120	20	with	with	ADP
biomedich-731	120	21	minimal	minimal	ADJ
biomedich-731	120	22	risk	risk	NOUN
biomedich-731	120	23	of	of	ADP
biomedich-731	120	24	adverse	adverse	ADJ
biomedich-731	120	25	effects	effect	NOUN
biomedich-731	120	26	.	.	PUNCT
biomedich-731	121	1	414	414	NUM
biomedich-731	121	2	biology	biology	NOUN
biomedich-731	121	3	,	,	PUNCT
biomedich-731	121	4	medicine	medicine	NOUN
biomedich-731	121	5	,	,	PUNCT
biomedich-731	121	6	&	&	CCONJ
biomedich-731	121	7	natural	natural	ADJ
biomedich-731	121	8	product	product	NOUN
biomedich-731	121	9	chemistry	chemistry	NOUN
biomedich-731	121	10	14	14	NUM
biomedich-731	121	11	(	(	PUNCT
biomedich-731	121	12	1	1	NUM
biomedich-731	121	13	)	)	PUNCT
biomedich-731	121	14	,	,	PUNCT
biomedich-731	121	15	2025	2025	NUM
biomedich-731	121	16	:	:	PUNCT
biomedich-731	121	17	409	409	NUM
biomedich-731	121	18	-	-	SYM
biomedich-731	121	19	415	415	NUM
biomedich-731	121	20	figure	figure	NOUN
biomedich-731	121	21	4	4	NUM
biomedich-731	121	22	.	.	PUNCT
biomedich-731	122	1	admet	admet	ADJ
biomedich-731	122	2	analysis	analysis	NOUN
biomedich-731	122	3	of	of	ADP
biomedich-731	122	4	flavonoid	flavonoid	NOUN
biomedich-731	122	5	drugs	drug	NOUN
biomedich-731	122	6	demonstrating	demonstrate	VERB
biomedich-731	122	7	profiles	profile	NOUN
biomedich-731	122	8	of	of	ADP
biomedich-731	122	9	absorption	absorption	NOUN
biomedich-731	122	10	,	,	PUNCT
biomedich-731	122	11	distribution	distribution	NOUN
biomedich-731	122	12	,	,	PUNCT
biomedich-731	122	13	metabolism	metabolism	NOUN
biomedich-731	122	14	,	,	PUNCT
biomedich-731	122	15	excretion	excretion	NOUN
biomedich-731	122	16	,	,	PUNCT
biomedich-731	122	17	and	and	CCONJ
biomedich-731	122	18	toxicity	toxicity	NOUN
biomedich-731	122	19	.	.	PUNCT
biomedich-731	123	1	this	this	DET
biomedich-731	123	2	data	data	NOUN
biomedich-731	123	3	is	be	AUX
biomedich-731	123	4	utilized	utilize	VERB
biomedich-731	123	5	to	to	PART
biomedich-731	123	6	assess	assess	VERB
biomedich-731	123	7	the	the	DET
biomedich-731	123	8	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	123	9	potential	potential	NOUN
biomedich-731	123	10	and	and	CCONJ
biomedich-731	123	11	safety	safety	NOUN
biomedich-731	123	12	of	of	ADP
biomedich-731	123	13	substances	substance	NOUN
biomedich-731	123	14	in	in	ADP
biomedich-731	123	15	medication	medication	NOUN
biomedich-731	123	16	development	development	NOUN
biomedich-731	123	17	.	.	PUNCT
biomedich-731	124	1	potential	potential	NOUN
biomedich-731	124	2	for	for	ADP
biomedich-731	124	3	further	further	ADJ
biomedich-731	124	4	development	development	NOUN
biomedich-731	124	5	the	the	DET
biomedich-731	124	6	potential	potential	NOUN
biomedich-731	124	7	for	for	ADP
biomedich-731	124	8	further	further	ADJ
biomedich-731	124	9	development	development	NOUN
biomedich-731	124	10	of	of	ADP
biomedich-731	124	11	4hydroxyisoleucine	4hydroxyisoleucine	NUM
biomedich-731	124	12	as	as	ADP
biomedich-731	124	13	a	a	DET
biomedich-731	124	14	therapeutic	therapeutic	ADJ
biomedich-731	124	15	agent	agent	NOUN
biomedich-731	124	16	is	be	AUX
biomedich-731	124	17	substantial	substantial	ADJ
biomedich-731	124	18	,	,	PUNCT
biomedich-731	124	19	particularly	particularly	ADV
biomedich-731	124	20	in	in	ADP
biomedich-731	124	21	treating	treat	VERB
biomedich-731	124	22	metabolic	metabolic	NOUN
biomedich-731	124	23	disorders	disorder	NOUN
biomedich-731	124	24	such	such	ADJ
biomedich-731	124	25	as	as	ADP
biomedich-731	124	26	diabetes	diabete	NOUN
biomedich-731	124	27	.	.	PUNCT
biomedich-731	125	1	given	give	VERB
biomedich-731	125	2	its	its	PRON
biomedich-731	125	3	promising	promise	VERB
biomedich-731	125	4	adme	adme	NOUN
biomedich-731	125	5	properties	property	NOUN
biomedich-731	125	6	,	,	PUNCT
biomedich-731	125	7	including	include	VERB
biomedich-731	125	8	high	high	ADJ
biomedich-731	125	9	gastrointestinal	gastrointestinal	ADJ
biomedich-731	125	10	absorption	absorption	NOUN
biomedich-731	125	11	,	,	PUNCT
biomedich-731	125	12	moderate	moderate	ADJ
biomedich-731	125	13	solubility	solubility	NOUN
biomedich-731	125	14	,	,	PUNCT
biomedich-731	125	15	and	and	CCONJ
biomedich-731	125	16	favorable	favorable	ADJ
biomedich-731	125	17	safety	safety	NOUN
biomedich-731	125	18	profile	profile	NOUN
biomedich-731	125	19	,	,	PUNCT
biomedich-731	125	20	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	125	21	shows	show	VERB
biomedich-731	125	22	strong	strong	ADJ
biomedich-731	125	23	potential	potential	NOUN
biomedich-731	125	24	for	for	ADP
biomedich-731	125	25	development	development	NOUN
biomedich-731	125	26	into	into	ADP
biomedich-731	125	27	an	an	DET
biomedich-731	125	28	effective	effective	ADJ
biomedich-731	125	29	,	,	PUNCT
biomedich-731	125	30	natural	natural	ADJ
biomedich-731	125	31	-	-	PUNCT
biomedich-731	125	32	based	base	VERB
biomedich-731	125	33	pharmaceutical	pharmaceutical	NOUN
biomedich-731	125	34	.	.	PUNCT
biomedich-731	126	1	its	its	PRON
biomedich-731	126	2	ability	ability	NOUN
biomedich-731	126	3	to	to	PART
biomedich-731	126	4	be	be	AUX
biomedich-731	126	5	efficiently	efficiently	ADV
biomedich-731	126	6	absorbed	absorb	VERB
biomedich-731	126	7	in	in	ADP
biomedich-731	126	8	the	the	DET
biomedich-731	126	9	digestive	digestive	ADJ
biomedich-731	126	10	tract	tract	NOUN
biomedich-731	126	11	and	and	CCONJ
biomedich-731	126	12	its	its	PRON
biomedich-731	126	13	relatively	relatively	ADV
biomedich-731	126	14	low	low	ADJ
biomedich-731	126	15	toxicity	toxicity	NOUN
biomedich-731	126	16	profile	profile	NOUN
biomedich-731	126	17	suggest	suggest	VERB
biomedich-731	126	18	that	that	SCONJ
biomedich-731	126	19	it	it	PRON
biomedich-731	126	20	could	could	AUX
biomedich-731	126	21	be	be	AUX
biomedich-731	126	22	a	a	DET
biomedich-731	126	23	safer	safe	ADJ
biomedich-731	126	24	alternative	alternative	NOUN
biomedich-731	126	25	to	to	ADP
biomedich-731	126	26	some	some	DET
biomedich-731	126	27	conventional	conventional	ADJ
biomedich-731	126	28	synthetic	synthetic	ADJ
biomedich-731	126	29	drugs	drug	NOUN
biomedich-731	126	30	,	,	PUNCT
biomedich-731	126	31	potentially	potentially	ADV
biomedich-731	126	32	reducing	reduce	VERB
biomedich-731	126	33	the	the	DET
biomedich-731	126	34	risk	risk	NOUN
biomedich-731	126	35	of	of	ADP
biomedich-731	126	36	adverse	adverse	ADJ
biomedich-731	126	37	effects	effect	NOUN
biomedich-731	126	38	commonly	commonly	ADV
biomedich-731	126	39	associated	associate	VERB
biomedich-731	126	40	with	with	ADP
biomedich-731	126	41	longterm	longterm	ADJ
biomedich-731	126	42	use	use	NOUN
biomedich-731	126	43	of	of	ADP
biomedich-731	126	44	synthetic	synthetic	ADJ
biomedich-731	126	45	antidiabetic	antidiabetic	ADJ
biomedich-731	126	46	agents	agent	NOUN
biomedich-731	126	47	.	.	PUNCT
biomedich-731	127	1	moreover	moreover	ADV
biomedich-731	127	2	,	,	PUNCT
biomedich-731	127	3	4	4	NUM
biomedich-731	127	4	-	-	PUNCT
biomedich-731	127	5	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	127	6	’s	’s	PART
biomedich-731	127	7	natural	natural	ADJ
biomedich-731	127	8	origin	origin	NOUN
biomedich-731	127	9	offers	offer	VERB
biomedich-731	127	10	an	an	DET
biomedich-731	127	11	added	add	VERB
biomedich-731	127	12	advantage	advantage	NOUN
biomedich-731	127	13	,	,	PUNCT
biomedich-731	127	14	as	as	SCONJ
biomedich-731	127	15	patients	patient	NOUN
biomedich-731	127	16	increasingly	increasingly	ADV
biomedich-731	127	17	seek	seek	VERB
biomedich-731	127	18	plantbased	plantbase	VERB
biomedich-731	127	19	or	or	CCONJ
biomedich-731	127	20	natural	natural	ADJ
biomedich-731	127	21	treatments	treatment	NOUN
biomedich-731	127	22	with	with	ADP
biomedich-731	127	23	fewer	few	ADJ
biomedich-731	127	24	side	side	NOUN
biomedich-731	127	25	effects	effect	NOUN
biomedich-731	127	26	.	.	PUNCT
biomedich-731	128	1	the	the	DET
biomedich-731	128	2	compound	compound	NOUN
biomedich-731	128	3	’s	’s	PART
biomedich-731	128	4	lower	low	ADJ
biomedich-731	128	5	molecular	molecular	ADJ
biomedich-731	128	6	weight	weight	NOUN
biomedich-731	128	7	and	and	CCONJ
biomedich-731	128	8	minimal	minimal	ADJ
biomedich-731	128	9	metabolism	metabolism	NOUN
biomedich-731	128	10	also	also	ADV
biomedich-731	128	11	indicate	indicate	VERB
biomedich-731	128	12	that	that	SCONJ
biomedich-731	128	13	it	it	PRON
biomedich-731	128	14	could	could	AUX
biomedich-731	128	15	be	be	AUX
biomedich-731	128	16	retained	retain	VERB
biomedich-731	128	17	in	in	ADP
biomedich-731	128	18	the	the	DET
biomedich-731	128	19	body	body	NOUN
biomedich-731	128	20	for	for	ADP
biomedich-731	128	21	a	a	DET
biomedich-731	128	22	longer	long	ADJ
biomedich-731	128	23	period	period	NOUN
biomedich-731	128	24	,	,	PUNCT
biomedich-731	128	25	potentially	potentially	ADV
biomedich-731	128	26	offering	offer	VERB
biomedich-731	128	27	more	more	ADJ
biomedich-731	128	28	sustained	sustained	ADJ
biomedich-731	128	29	therapeutic	therapeutic	ADJ
biomedich-731	128	30	effects	effect	NOUN
biomedich-731	128	31	.	.	PUNCT
biomedich-731	129	1	the	the	DET
biomedich-731	129	2	fact	fact	NOUN
biomedich-731	129	3	that	that	SCONJ
biomedich-731	129	4	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	129	5	has	have	AUX
biomedich-731	129	6	been	be	AUX
biomedich-731	129	7	shown	show	VERB
biomedich-731	129	8	to	to	PART
biomedich-731	129	9	interact	interact	VERB
biomedich-731	129	10	with	with	ADP
biomedich-731	129	11	key	key	ADJ
biomedich-731	129	12	targets	target	NOUN
biomedich-731	129	13	such	such	ADJ
biomedich-731	129	14	as	as	ADP
biomedich-731	129	15	the	the	DET
biomedich-731	129	16	dpp-4	dpp-4	ADJ
biomedich-731	129	17	enzyme	enzyme	NOUN
biomedich-731	129	18	further	far	ADV
biomedich-731	129	19	enhances	enhance	VERB
biomedich-731	129	20	its	its	PRON
biomedich-731	129	21	potential	potential	NOUN
biomedich-731	129	22	as	as	ADP
biomedich-731	129	23	a	a	DET
biomedich-731	129	24	promising	promising	ADJ
biomedich-731	129	25	agent	agent	NOUN
biomedich-731	129	26	for	for	ADP
biomedich-731	129	27	diabetes	diabetes	NOUN
biomedich-731	129	28	management	management	NOUN
biomedich-731	129	29	.	.	PUNCT
biomedich-731	130	1	inhibiting	inhibit	VERB
biomedich-731	130	2	dpp-4	dpp-4	PRON
biomedich-731	130	3	can	can	AUX
biomedich-731	130	4	lead	lead	VERB
biomedich-731	130	5	to	to	ADP
biomedich-731	130	6	improved	improve	VERB
biomedich-731	130	7	insulin	insulin	NOUN
biomedich-731	130	8	secretion	secretion	NOUN
biomedich-731	130	9	and	and	CCONJ
biomedich-731	130	10	better	well	ADJ
biomedich-731	130	11	blood	blood	NOUN
biomedich-731	130	12	glucose	glucose	NOUN
biomedich-731	130	13	regulation	regulation	NOUN
biomedich-731	130	14	,	,	PUNCT
biomedich-731	130	15	which	which	PRON
biomedich-731	130	16	is	be	AUX
biomedich-731	130	17	critical	critical	ADJ
biomedich-731	130	18	for	for	ADP
biomedich-731	130	19	diabetes	diabetes	NOUN
biomedich-731	130	20	treatment	treatment	NOUN
biomedich-731	130	21	(	(	PUNCT
biomedich-731	130	22	xiao	xiao	PROPN
biomedich-731	130	23	et	et	PROPN
biomedich-731	130	24	al	al	PROPN
biomedich-731	130	25	.	.	PROPN
biomedich-731	130	26	,	,	PUNCT
biomedich-731	130	27	2018	2018	NUM
biomedich-731	130	28	)	)	PUNCT
biomedich-731	130	29	.	.	PUNCT
biomedich-731	131	1	in	in	ADP
biomedich-731	131	2	addition	addition	NOUN
biomedich-731	131	3	,	,	PUNCT
biomedich-731	131	4	the	the	DET
biomedich-731	131	5	promising	promising	ADJ
biomedich-731	131	6	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	131	7	characteristics	characteristic	NOUN
biomedich-731	131	8	of	of	ADP
biomedich-731	131	9	4	4	NUM
biomedich-731	131	10	-	-	PUNCT
biomedich-731	131	11	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	131	12	,	,	PUNCT
biomedich-731	131	13	coupled	couple	VERB
biomedich-731	131	14	with	with	ADP
biomedich-731	131	15	its	its	PRON
biomedich-731	131	16	low	low	ADJ
biomedich-731	131	17	hepatotoxicity	hepatotoxicity	NOUN
biomedich-731	131	18	and	and	CCONJ
biomedich-731	131	19	lack	lack	NOUN
biomedich-731	131	20	of	of	ADP
biomedich-731	131	21	mutagenic	mutagenic	ADJ
biomedich-731	131	22	or	or	CCONJ
biomedich-731	131	23	carcinogenic	carcinogenic	ADJ
biomedich-731	131	24	properties	property	NOUN
biomedich-731	131	25	,	,	PUNCT
biomedich-731	131	26	position	position	VERB
biomedich-731	131	27	it	it	PRON
biomedich-731	131	28	as	as	ADP
biomedich-731	131	29	a	a	DET
biomedich-731	131	30	safe	safe	ADJ
biomedich-731	131	31	candidate	candidate	NOUN
biomedich-731	131	32	for	for	ADP
biomedich-731	131	33	use	use	NOUN
biomedich-731	131	34	in	in	ADP
biomedich-731	131	35	future	future	ADJ
biomedich-731	131	36	drug	drug	NOUN
biomedich-731	131	37	formulations	formulation	NOUN
biomedich-731	131	38	.	.	PUNCT
biomedich-731	132	1	the	the	DET
biomedich-731	132	2	compound	compound	NOUN
biomedich-731	132	3	’s	’s	PART
biomedich-731	132	4	relatively	relatively	ADV
biomedich-731	132	5	low	low	ADJ
biomedich-731	132	6	binding	bind	VERB
biomedich-731	132	7	affinity	affinity	NOUN
biomedich-731	132	8	compared	compare	VERB
biomedich-731	132	9	to	to	ADP
biomedich-731	132	10	synthetic	synthetic	VERB
biomedich-731	132	11	dpp-4	dpp-4	ADJ
biomedich-731	132	12	inhibitors	inhibitor	NOUN
biomedich-731	132	13	does	do	AUX
biomedich-731	132	14	not	not	PART
biomedich-731	132	15	necessarily	necessarily	ADV
biomedich-731	132	16	diminish	diminish	VERB
biomedich-731	132	17	its	its	PRON
biomedich-731	132	18	therapeutic	therapeutic	ADJ
biomedich-731	132	19	potential	potential	NOUN
biomedich-731	132	20	,	,	PUNCT
biomedich-731	132	21	as	as	SCONJ
biomedich-731	132	22	further	further	ADJ
biomedich-731	132	23	optimization	optimization	NOUN
biomedich-731	132	24	and	and	CCONJ
biomedich-731	132	25	combination	combination	NOUN
biomedich-731	132	26	therapies	therapy	NOUN
biomedich-731	132	27	could	could	AUX
biomedich-731	132	28	enhance	enhance	VERB
biomedich-731	132	29	its	its	PRON
biomedich-731	132	30	efficacy	efficacy	NOUN
biomedich-731	132	31	.	.	PUNCT
biomedich-731	133	1	the	the	DET
biomedich-731	133	2	future	future	ADJ
biomedich-731	133	3	development	development	NOUN
biomedich-731	133	4	of	of	ADP
biomedich-731	133	5	4	4	NUM
biomedich-731	133	6	-	-	PUNCT
biomedich-731	133	7	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	133	8	could	could	AUX
biomedich-731	133	9	involve	involve	VERB
biomedich-731	133	10	clinical	clinical	ADJ
biomedich-731	133	11	studies	study	NOUN
biomedich-731	133	12	to	to	PART
biomedich-731	133	13	validate	validate	VERB
biomedich-731	133	14	its	its	PRON
biomedich-731	133	15	efficacy	efficacy	NOUN
biomedich-731	133	16	in	in	ADP
biomedich-731	133	17	human	human	ADJ
biomedich-731	133	18	trials	trial	NOUN
biomedich-731	133	19	,	,	PUNCT
biomedich-731	133	20	explore	explore	VERB
biomedich-731	133	21	its	its	PRON
biomedich-731	133	22	long	long	ADJ
biomedich-731	133	23	-	-	PUNCT
biomedich-731	133	24	term	term	NOUN
biomedich-731	133	25	safety	safety	NOUN
biomedich-731	133	26	,	,	PUNCT
biomedich-731	133	27	and	and	CCONJ
biomedich-731	133	28	refine	refine	VERB
biomedich-731	133	29	formulations	formulation	NOUN
biomedich-731	133	30	for	for	ADP
biomedich-731	133	31	maximum	maximum	ADJ
biomedich-731	133	32	bioavailability	bioavailability	NOUN
biomedich-731	133	33	and	and	CCONJ
biomedich-731	133	34	therapeutic	therapeutic	ADJ
biomedich-731	133	35	benefit	benefit	NOUN
biomedich-731	133	36	.	.	PUNCT
biomedich-731	134	1	its	its	PRON
biomedich-731	134	2	natural	natural	ADJ
biomedich-731	134	3	composition	composition	NOUN
biomedich-731	134	4	and	and	CCONJ
biomedich-731	134	5	minimal	minimal	ADJ
biomedich-731	134	6	toxicity	toxicity	NOUN
biomedich-731	134	7	profile	profile	NOUN
biomedich-731	134	8	suggest	suggest	VERB
biomedich-731	134	9	that	that	SCONJ
biomedich-731	134	10	,	,	PUNCT
biomedich-731	134	11	with	with	ADP
biomedich-731	134	12	further	further	ADJ
biomedich-731	134	13	research	research	NOUN
biomedich-731	134	14	and	and	CCONJ
biomedich-731	134	15	development	development	NOUN
biomedich-731	134	16	,	,	PUNCT
biomedich-731	134	17	it	it	PRON
biomedich-731	134	18	could	could	AUX
biomedich-731	134	19	become	become	VERB
biomedich-731	134	20	a	a	DET
biomedich-731	134	21	valuable	valuable	ADJ
biomedich-731	134	22	addition	addition	NOUN
biomedich-731	134	23	to	to	ADP
biomedich-731	134	24	the	the	DET
biomedich-731	134	25	array	array	NOUN
biomedich-731	134	26	of	of	ADP
biomedich-731	134	27	treatments	treatment	NOUN
biomedich-731	134	28	available	available	ADJ
biomedich-731	134	29	for	for	ADP
biomedich-731	134	30	managing	manage	VERB
biomedich-731	134	31	diabetes	diabetes	NOUN
biomedich-731	134	32	and	and	CCONJ
biomedich-731	134	33	other	other	ADJ
biomedich-731	134	34	metabolic	metabolic	NOUN
biomedich-731	134	35	conditions	condition	NOUN
biomedich-731	134	36	.	.	PUNCT
biomedich-731	135	1	thus	thus	ADV
biomedich-731	135	2	,	,	PUNCT
biomedich-731	135	3	the	the	DET
biomedich-731	135	4	continued	continue	VERB
biomedich-731	135	5	exploration	exploration	NOUN
biomedich-731	135	6	of	of	ADP
biomedich-731	135	7	4	4	NUM
biomedich-731	135	8	-	-	PUNCT
biomedich-731	135	9	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	135	10	’s	’s	PART
biomedich-731	135	11	pharmacological	pharmacological	ADJ
biomedich-731	135	12	properties	property	NOUN
biomedich-731	135	13	holds	hold	VERB
biomedich-731	135	14	significant	significant	ADJ
biomedich-731	135	15	promise	promise	NOUN
biomedich-731	135	16	for	for	ADP
biomedich-731	135	17	advancing	advance	VERB
biomedich-731	135	18	natural	natural	ADJ
biomedich-731	135	19	-	-	PUNCT
biomedich-731	135	20	based	base	VERB
biomedich-731	135	21	therapies	therapy	NOUN
biomedich-731	135	22	in	in	ADP
biomedich-731	135	23	medicine	medicine	NOUN
biomedich-731	135	24	(	(	PUNCT
biomedich-731	135	25	yuan	yuan	NOUN
biomedich-731	135	26	et	et	NOUN
biomedich-731	135	27	al	al	PROPN
biomedich-731	135	28	.	.	PROPN
biomedich-731	135	29	,	,	PUNCT
biomedich-731	135	30	2017	2017	NUM
biomedich-731	135	31	)	)	PUNCT
biomedich-731	135	32	.	.	PUNCT
biomedich-731	136	1	thalib	thalib	PROPN
biomedich-731	136	2	&	&	CCONJ
biomedich-731	136	3	damayanti	damayanti	PROPN
biomedich-731	136	4	–	–	PUNCT
biomedich-731	136	5	4	4	NUM
biomedich-731	136	6	-	-	NOUN
biomedich-731	136	7	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	136	8	as	as	ADP
biomedich-731	136	9	a	a	DET
biomedich-731	136	10	natural	natural	ADJ
biomedich-731	136	11	dpp-4	dpp-4	ADJ
biomedich-731	136	12	inhibitor	inhibitor	NOUN
biomedich-731	136	13	for	for	ADP
biomedich-731	136	14	diabetes	diabetes	NOUN
biomedich-731	136	15	415	415	NUM
biomedich-731	136	16	conclusions	conclusion	NOUN
biomedich-731	136	17	this	this	DET
biomedich-731	136	18	study	study	NOUN
biomedich-731	136	19	of	of	ADP
biomedich-731	136	20	4	4	NUM
biomedich-731	136	21	-	-	PUNCT
biomedich-731	136	22	hydroxyisoleucine	hydroxyisoleucine	NOUN
biomedich-731	136	23	presents	present	VERB
biomedich-731	136	24	a	a	DET
biomedich-731	136	25	promising	promising	ADJ
biomedich-731	136	26	candidate	candidate	NOUN
biomedich-731	136	27	for	for	ADP
biomedich-731	136	28	further	further	ADJ
biomedich-731	136	29	development	development	NOUN
biomedich-731	136	30	as	as	ADP
biomedich-731	136	31	a	a	DET
biomedich-731	136	32	natural	natural	ADJ
biomedich-731	136	33	therapeutic	therapeutic	ADJ
biomedich-731	136	34	agent	agent	NOUN
biomedich-731	136	35	,	,	PUNCT
biomedich-731	136	36	particularly	particularly	ADV
biomedich-731	136	37	for	for	ADP
biomedich-731	136	38	treating	treat	VERB
biomedich-731	136	39	diabetes	diabetes	NOUN
biomedich-731	136	40	.	.	PUNCT
biomedich-731	137	1	its	its	PRON
biomedich-731	137	2	favorable	favorable	ADJ
biomedich-731	137	3	adme	adme	NOUN
biomedich-731	137	4	properties	property	NOUN
biomedich-731	137	5	,	,	PUNCT
biomedich-731	137	6	including	include	VERB
biomedich-731	137	7	high	high	ADJ
biomedich-731	137	8	gastrointestinal	gastrointestinal	ADJ
biomedich-731	137	9	absorption	absorption	NOUN
biomedich-731	137	10	,	,	PUNCT
biomedich-731	137	11	moderate	moderate	ADJ
biomedich-731	137	12	solubility	solubility	NOUN
biomedich-731	137	13	,	,	PUNCT
biomedich-731	137	14	and	and	CCONJ
biomedich-731	137	15	minimal	minimal	ADJ
biomedich-731	137	16	toxicity	toxicity	NOUN
biomedich-731	137	17	,	,	PUNCT
biomedich-731	137	18	position	position	VERB
biomedich-731	137	19	it	it	PRON
biomedich-731	137	20	as	as	ADP
biomedich-731	137	21	a	a	DET
biomedich-731	137	22	viable	viable	ADJ
biomedich-731	137	23	alternative	alternative	NOUN
biomedich-731	137	24	to	to	AUX
biomedich-731	137	25	synthetic	synthetic	VERB
biomedich-731	137	26	dpp-4	dpp-4	ADJ
biomedich-731	137	27	inhibitors	inhibitor	NOUN
biomedich-731	137	28	.	.	PUNCT
biomedich-731	138	1	the	the	DET
biomedich-731	138	2	compound	compound	NOUN
biomedich-731	138	3	’s	’s	PART
biomedich-731	138	4	ability	ability	NOUN
biomedich-731	138	5	to	to	PART
biomedich-731	138	6	interact	interact	VERB
biomedich-731	138	7	with	with	ADP
biomedich-731	138	8	key	key	ADJ
biomedich-731	138	9	targets	target	NOUN
biomedich-731	138	10	involved	involve	VERB
biomedich-731	138	11	in	in	ADP
biomedich-731	138	12	glucose	glucose	NOUN
biomedich-731	138	13	regulation	regulation	NOUN
biomedich-731	138	14	,	,	PUNCT
biomedich-731	138	15	along	along	ADP
biomedich-731	138	16	with	with	ADP
biomedich-731	138	17	its	its	PRON
biomedich-731	138	18	low	low	ADJ
biomedich-731	138	19	risk	risk	NOUN
biomedich-731	138	20	of	of	ADP
biomedich-731	138	21	adverse	adverse	ADJ
biomedich-731	138	22	effects	effect	NOUN
biomedich-731	138	23	,	,	PUNCT
biomedich-731	138	24	makes	make	VERB
biomedich-731	138	25	it	it	PRON
biomedich-731	138	26	an	an	DET
biomedich-731	138	27	attractive	attractive	ADJ
biomedich-731	138	28	option	option	NOUN
biomedich-731	138	29	for	for	ADP
biomedich-731	138	30	future	future	ADJ
biomedich-731	138	31	drug	drug	NOUN
biomedich-731	138	32	development	development	NOUN
biomedich-731	138	33	.	.	PUNCT
biomedich-731	139	1	while	while	SCONJ
biomedich-731	139	2	its	its	PRON
biomedich-731	139	3	binding	bind	VERB
biomedich-731	139	4	affinity	affinity	NOUN
biomedich-731	139	5	to	to	PART
biomedich-731	139	6	dpp-4	dpp-4	ADV
biomedich-731	139	7	is	be	AUX
biomedich-731	139	8	lower	low	ADJ
biomedich-731	139	9	than	than	ADP
biomedich-731	139	10	of	of	ADP
biomedich-731	139	11	synthetic	synthetic	ADJ
biomedich-731	139	12	inhibitors	inhibitor	NOUN
biomedich-731	139	13	,	,	PUNCT
biomedich-731	139	14	its	its	PRON
biomedich-731	139	15	natural	natural	ADJ
biomedich-731	139	16	origin	origin	NOUN
biomedich-731	139	17	,	,	PUNCT
biomedich-731	139	18	simple	simple	ADJ
biomedich-731	139	19	molecular	molecular	ADJ
biomedich-731	139	20	structure	structure	NOUN
biomedich-731	139	21	,	,	PUNCT
biomedich-731	139	22	and	and	CCONJ
biomedich-731	139	23	potential	potential	NOUN
biomedich-731	139	24	for	for	ADP
biomedich-731	139	25	sustained	sustain	VERB
biomedich-731	139	26	therapeutic	therapeutic	ADJ
biomedich-731	139	27	effects	effect	NOUN
biomedich-731	139	28	warrant	warrant	VERB
biomedich-731	139	29	further	further	ADJ
biomedich-731	139	30	research	research	NOUN
biomedich-731	139	31	and	and	CCONJ
biomedich-731	139	32	optimization	optimization	NOUN
biomedich-731	139	33	.	.	PUNCT
biomedich-731	140	1	overall	overall	ADV
biomedich-731	140	2	,	,	PUNCT
biomedich-731	140	3	4hydroxyisoleucine	4hydroxyisoleucine	PROPN
biomedich-731	140	4	's	's	PART
biomedich-731	140	5	promising	promising	ADJ
biomedich-731	140	6	pharmacokinetic	pharmacokinetic	ADJ
biomedich-731	140	7	profile	profile	NOUN
biomedich-731	140	8	,	,	PUNCT
biomedich-731	140	9	coupled	couple	VERB
biomedich-731	140	10	with	with	ADP
biomedich-731	140	11	its	its	PRON
biomedich-731	140	12	safety	safety	NOUN
biomedich-731	140	13	and	and	CCONJ
biomedich-731	140	14	efficacy	efficacy	NOUN
biomedich-731	140	15	,	,	PUNCT
biomedich-731	140	16	suggest	suggest	VERB
biomedich-731	140	17	that	that	SCONJ
biomedich-731	140	18	it	it	PRON
biomedich-731	140	19	could	could	AUX
biomedich-731	140	20	play	play	VERB
biomedich-731	140	21	an	an	DET
biomedich-731	140	22	important	important	ADJ
biomedich-731	140	23	role	role	NOUN
biomedich-731	140	24	in	in	ADP
biomedich-731	140	25	the	the	DET
biomedich-731	140	26	development	development	NOUN
biomedich-731	140	27	of	of	ADP
biomedich-731	140	28	naturalbased	naturalbased	ADJ
biomedich-731	140	29	therapies	therapy	NOUN
biomedich-731	140	30	for	for	ADP
biomedich-731	140	31	diabetes	diabetes	NOUN
biomedich-731	140	32	and	and	CCONJ
biomedich-731	140	33	other	other	ADJ
biomedich-731	140	34	metabolic	metabolic	NOUN
biomedich-731	140	35	disorders	disorder	NOUN
biomedich-731	140	36	.	.	PUNCT
biomedich-731	141	1	acknowledgements	acknowledgement	NOUN
biomedich-731	141	2	:	:	PUNCT
biomedich-731	141	3	the	the	DET
biomedich-731	141	4	author	author	NOUN
biomedich-731	141	5	thanks	thank	NOUN
biomedich-731	141	6	to	to	ADP
biomedich-731	141	7	university	university	PROPN
biomedich-731	141	8	of	of	ADP
biomedich-731	141	9	muhammadiyah	muhammadiyah	NOUN
biomedich-731	141	10	purwokerto	purwokerto	NOUN
biomedich-731	141	11	for	for	ADP
biomedich-731	141	12	the	the	DET
biomedich-731	141	13	time	time	NOUN
biomedich-731	141	14	given	give	VERB
biomedich-731	141	15	to	to	PART
biomedich-731	141	16	conduct	conduct	VERB
biomedich-731	141	17	research	research	NOUN
biomedich-731	141	18	as	as	ADV
biomedich-731	141	19	well	well	ADV
biomedich-731	141	20	as	as	ADP
biomedich-731	141	21	the	the	DET
biomedich-731	141	22	provision	provision	NOUN
biomedich-731	141	23	of	of	ADP
biomedich-731	141	24	computers	computer	NOUN
biomedich-731	141	25	for	for	ADP
biomedich-731	141	26	docking	dock	VERB
biomedich-731	141	27	with	with	ADP
biomedich-731	141	28	the	the	DET
biomedich-731	141	29	required	require	VERB
biomedich-731	141	30	specifications	specification	NOUN
biomedich-731	141	31	.	.	PUNCT
biomedich-731	142	1	authors	author	NOUN
biomedich-731	142	2	’	'	PUNCT
biomedich-731	142	3	contributions	contribution	NOUN
biomedich-731	142	4	:	:	PUNCT
biomedich-731	142	5	irma	irma	PROPN
biomedich-731	142	6	putri	putri	PROPN
biomedich-731	142	7	damayanti	damayanti	PROPN
biomedich-731	142	8	to	to	PART
biomedich-731	142	9	designed	design	VERB
biomedich-731	142	10	the	the	DET
biomedich-731	142	11	study	study	NOUN
biomedich-731	142	12	,	,	PUNCT
biomedich-731	142	13	provide	provide	VERB
biomedich-731	142	14	input	input	NOUN
biomedich-731	142	15	and	and	CCONJ
biomedich-731	142	16	supervise	supervise	VERB
biomedich-731	142	17	the	the	DET
biomedich-731	142	18	docking	docking	NOUN
biomedich-731	142	19	.	.	PUNCT
biomedich-731	143	1	amir	amir	PROPN
biomedich-731	143	2	carried	carry	VERB
biomedich-731	143	3	out	out	ADP
biomedich-731	143	4	the	the	DET
biomedich-731	143	5	docking	docking	NOUN
biomedich-731	143	6	work	work	NOUN
biomedich-731	143	7	,	,	PUNCT
biomedich-731	143	8	analyzed	analyze	VERB
biomedich-731	143	9	the	the	DET
biomedich-731	143	10	data	datum	NOUN
biomedich-731	143	11	and	and	CCONJ
biomedich-731	143	12	wrote	write	VERB
biomedich-731	143	13	the	the	DET
biomedich-731	143	14	manuscript	manuscript	NOUN
biomedich-731	143	15	.	.	PUNCT
biomedich-731	144	1	all	all	DET
biomedich-731	144	2	authors	author	NOUN
biomedich-731	144	3	read	read	VERB
biomedich-731	144	4	and	and	CCONJ
biomedich-731	144	5	approved	approve	VERB
biomedich-731	144	6	the	the	DET
biomedich-731	144	7	final	final	ADJ
biomedich-731	144	8	version	version	NOUN
biomedich-731	144	9	of	of	ADP
biomedich-731	144	10	the	the	DET
biomedich-731	144	11	manuscript	manuscript	NOUN
biomedich-731	144	12	competing	compete	VERB
biomedich-731	144	13	interests	interest	NOUN
biomedich-731	144	14	:	:	PUNCT
biomedich-731	144	15	the	the	DET
biomedich-731	144	16	authors	author	NOUN
biomedich-731	144	17	declare	declare	VERB
biomedich-731	144	18	that	that	SCONJ
biomedich-731	144	19	there	there	PRON
biomedich-731	144	20	are	be	VERB
biomedich-731	144	21	no	no	DET
biomedich-731	144	22	competing	compete	VERB
biomedich-731	144	23	interests	interest	NOUN
biomedich-731	144	24	.	.	PUNCT
biomedich-731	145	1	funding	funding	NOUN
biomedich-731	145	2	:	:	PUNCT
biomedich-731	145	3	the	the	DET
biomedich-731	145	4	authors	author	NOUN
biomedich-731	145	5	declare	declare	VERB
biomedich-731	145	6	no	no	DET
biomedich-731	145	7	funding	funding	NOUN
biomedich-731	145	8	in	in	ADP
biomedich-731	145	9	this	this	DET
biomedich-731	145	10	research	research	NOUN
biomedich-731	145	11	.	.	PUNCT
biomedich-731	146	1	references	reference	NOUN
biomedich-731	146	2	anitha	anitha	PROPN
biomedich-731	146	3	,	,	PUNCT
biomedich-731	146	4	k.	k.	PROPN
biomedich-731	146	5	,	,	PUNCT
biomedich-731	146	6	gopi	gopi	PROPN
biomedich-731	146	7	,	,	PUNCT
biomedich-731	146	8	g.	g.	PROPN
biomedich-731	146	9	,	,	PUNCT
biomedich-731	146	10	girish	girish	PROPN
biomedich-731	146	11	,	,	PUNCT
biomedich-731	146	12	&	&	CCONJ
biomedich-731	146	13	kumar	kumar	PROPN
biomedich-731	146	14	,	,	PUNCT
biomedich-731	146	15	p.	p.	PROPN
biomedich-731	146	16	s.	s.	PROPN
biomedich-731	147	1	(	(	PUNCT
biomedich-731	147	2	2013	2013	NUM
biomedich-731	147	3	)	)	PUNCT
biomedich-731	147	4	.	.	PUNCT
biomedich-731	148	1	molecular	molecular	ADJ
biomedich-731	148	2	docking	docking	NOUN
biomedich-731	148	3	study	study	NOUN
biomedich-731	148	4	on	on	ADP
biomedich-731	148	5	dipeptidyl	dipeptidyl	NOUN
biomedich-731	148	6	peptidase-4	peptidase-4	NOUN
biomedich-731	148	7	inhibitors	inhibitor	NOUN
biomedich-731	148	8	.	.	PUNCT
biomedich-731	149	1	international	international	ADJ
biomedich-731	149	2	journal	journal	PROPN
biomedich-731	149	3	of	of	ADP
biomedich-731	149	4	research	research	NOUN
biomedich-731	149	5	and	and	CCONJ
biomedich-731	149	6	development	development	NOUN
biomedich-731	149	7	in	in	ADP
biomedich-731	149	8	pharmacy	pharmacy	NOUN
biomedich-731	149	9	and	and	CCONJ
biomedich-731	149	10	life	life	NOUN
biomedich-731	149	11	sciences	science	NOUN
biomedich-731	149	12	,	,	PUNCT
biomedich-731	149	13	2(5	2(5	NUM
biomedich-731	149	14	)	)	PUNCT
biomedich-731	149	15	,	,	PUNCT
biomedich-731	149	16	602–610	602–610	NUM
biomedich-731	149	17	.	.	PUNCT
biomedich-731	150	1	azriful	azriful	ADJ
biomedich-731	150	2	,	,	PUNCT
biomedich-731	150	3	n.	n.	NOUN
biomedich-731	150	4	,	,	PUNCT
biomedich-731	150	5	&	&	CCONJ
biomedich-731	150	6	habibi	habibi	PROPN
biomedich-731	150	7	,	,	PUNCT
biomedich-731	150	8	j.	j.	PROPN
biomedich-731	150	9	d.	d.	PROPN
biomedich-731	150	10	(	(	PUNCT
biomedich-731	150	11	2018	2018	NUM
biomedich-731	150	12	)	)	PUNCT
biomedich-731	150	13	.	.	PUNCT
biomedich-731	151	1	hubungan	hubungan	PROPN
biomedich-731	151	2	tingkat	tingkat	PROPN
biomedich-731	151	3	pengetahuan	pengetahuan	PROPN
biomedich-731	151	4	faktor	faktor	PROPN
biomedich-731	151	5	risiko	risiko	PROPN
biomedich-731	151	6	dm	dm	PROPN
biomedich-731	151	7	dengan	dengan	PROPN
biomedich-731	151	8	status	status	PROPN
biomedich-731	151	9	dm	dm	PROPN
biomedich-731	151	10	pada	pada	PROPN
biomedich-731	151	11	pegawai	pegawai	PROPN
biomedich-731	151	12	negeri	negeri	PROPN
biomedich-731	151	13	sipil	sipil	PROPN
biomedich-731	151	14	uin	uin	PROPN
biomedich-731	151	15	alauddin	alauddin	NOUN
biomedich-731	151	16	makassar	makassar	NOUN
biomedich-731	151	17	.	.	PUNCT
biomedich-731	152	1	al	al	PROPN
biomedich-731	152	2	-	-	PUNCT
biomedich-731	152	3	sihah	sihah	ADJ
biomedich-731	152	4	,	,	PUNCT
biomedich-731	152	5	10(1	10(1	NUM
biomedich-731	152	6	)	)	PUNCT
biomedich-731	152	7	,	,	PUNCT
biomedich-731	152	8	63–71	63–71	NOUN
biomedich-731	152	9	.	.	PUNCT
biomedich-731	153	1	itoh	itoh	PROPN
biomedich-731	153	2	,	,	PUNCT
biomedich-731	153	3	y.	y.	PROPN
biomedich-731	153	4	,	,	PUNCT
biomedich-731	153	5	nakashima	nakashima	PROPN
biomedich-731	153	6	,	,	PUNCT
biomedich-731	153	7	y.	y.	PROPN
biomedich-731	153	8	,	,	PUNCT
biomedich-731	153	9	tsukamoto	tsukamoto	NOUN
biomedich-731	153	10	,	,	PUNCT
biomedich-731	153	11	s.	s.	PROPN
biomedich-731	153	12	,	,	PUNCT
biomedich-731	153	13	kurohara	kurohara	PROPN
biomedich-731	153	14	,	,	PUNCT
biomedich-731	153	15	t.	t.	PROPN
biomedich-731	153	16	,	,	PUNCT
biomedich-731	153	17	suzuki	suzuki	PROPN
biomedich-731	153	18	,	,	PUNCT
biomedich-731	153	19	m.	m.	NOUN
biomedich-731	153	20	,	,	PUNCT
biomedich-731	153	21	sakae	sakae	NOUN
biomedich-731	153	22	,	,	PUNCT
biomedich-731	153	23	y.	y.	PROPN
biomedich-731	153	24	,	,	PUNCT
biomedich-731	153	25	oda	oda	PROPN
biomedich-731	153	26	,	,	PUNCT
biomedich-731	153	27	m.	m.	NOUN
biomedich-731	153	28	,	,	PUNCT
biomedich-731	153	29	okamoto	okamoto	PROPN
biomedich-731	153	30	,	,	PUNCT
biomedich-731	153	31	y.	y.	PROPN
biomedich-731	153	32	,	,	PUNCT
biomedich-731	153	33	&	&	CCONJ
biomedich-731	153	34	suzuki	suzuki	PROPN
biomedich-731	153	35	,	,	PUNCT
biomedich-731	153	36	t.	t.	PROPN
biomedich-731	153	37	(	(	PUNCT
biomedich-731	153	38	2019	2019	NUM
biomedich-731	153	39	)	)	PUNCT
biomedich-731	153	40	.	.	PUNCT
biomedich-731	154	1	n+-ch•••o	n+-ch•••o	PROPN
biomedich-731	154	2	hydrogen	hydrogen	NOUN
biomedich-731	154	3	bonds	bond	NOUN
biomedich-731	154	4	in	in	ADP
biomedich-731	154	5	protein	protein	NOUN
biomedich-731	154	6	-	-	PUNCT
biomedich-731	154	7	ligand	ligand	NOUN
biomedich-731	154	8	complexes	complex	NOUN
biomedich-731	154	9	.	.	PUNCT
biomedich-731	155	1	scientific	scientific	ADJ
biomedich-731	155	2	reports	report	NOUN
biomedich-731	155	3	,	,	PUNCT
biomedich-731	155	4	9(1	9(1	NUM
biomedich-731	155	5	)	)	PUNCT
biomedich-731	155	6	,	,	PUNCT
biomedich-731	155	7	1–5	1–5	X
biomedich-731	155	8	.	.	PUNCT
biomedich-731	155	9	made	make	VERB
biomedich-731	155	10	,	,	PUNCT
biomedich-731	155	11	p.	p.	NOUN
biomedich-731	155	12	,	,	PUNCT
biomedich-731	155	13	&	&	CCONJ
biomedich-731	155	14	pathni	pathni	PROPN
biomedich-731	155	15	,	,	PUNCT
biomedich-731	155	16	s.	s.	PROPN
biomedich-731	155	17	d.	d.	PROPN
biomedich-731	155	18	(	(	PUNCT
biomedich-731	155	19	2018	2018	NUM
biomedich-731	155	20	)	)	PUNCT
biomedich-731	155	21	.	.	PUNCT
biomedich-731	156	1	tren	tren	PROPN
biomedich-731	156	2	terapi	terapi	PROPN
biomedich-731	156	3	diabetes	diabete	VERB
biomedich-731	156	4	dengan	dengan	PROPN
biomedich-731	156	5	glp-1	glp-1	PRON
biomedich-731	156	6	receptor	receptor	NOUN
biomedich-731	156	7	agonist	agonist	NOUN
biomedich-731	156	8	.	.	PUNCT
biomedich-731	157	1	cermin	cermin	NOUN
biomedich-731	157	2	dunia	dunia	PROPN
biomedich-731	157	3	kedokteran	kedokteran	PROPN
biomedich-731	157	4	,	,	PUNCT
biomedich-731	157	5	45(4	45(4	PROPN
biomedich-731	157	6	)	)	PUNCT
biomedich-731	157	7	,	,	PUNCT
biomedich-731	157	8	291–296	291–296	NUM
biomedich-731	157	9	.	.	PUNCT
biomedich-731	158	1	nayeem	nayeem	PROPN
biomedich-731	158	2	,	,	PUNCT
biomedich-731	158	3	s.	s.	PROPN
biomedich-731	158	4	m.	m.	PROPN
biomedich-731	158	5	,	,	PUNCT
biomedich-731	158	6	sohail	sohail	PROPN
biomedich-731	158	7	,	,	PUNCT
biomedich-731	158	8	e.	e.	PROPN
biomedich-731	158	9	m.	m.	PROPN
biomedich-731	158	10	,	,	PUNCT
biomedich-731	158	11	ridhima	ridhima	PROPN
biomedich-731	158	12	,	,	PUNCT
biomedich-731	158	13	g.	g.	PROPN
biomedich-731	158	14	,	,	PUNCT
biomedich-731	158	15	&	&	CCONJ
biomedich-731	158	16	reddy	reddy	PROPN
biomedich-731	158	17	,	,	PUNCT
biomedich-731	158	18	m.	m.	NOUN
biomedich-731	158	19	s.	s.	PROPN
biomedich-731	158	20	(	(	PUNCT
biomedich-731	158	21	2021	2021	NUM
biomedich-731	158	22	)	)	PUNCT
biomedich-731	158	23	.	.	PUNCT
biomedich-731	159	1	target	target	VERB
biomedich-731	159	2	sars	sar	NOUN
biomedich-731	159	3	-	-	PUNCT
biomedich-731	159	4	cov-2	cov-2	NOUN
biomedich-731	159	5	:	:	PUNCT
biomedich-731	159	6	computation	computation	NOUN
biomedich-731	159	7	of	of	ADP
biomedich-731	159	8	binding	bind	VERB
biomedich-731	159	9	energies	energy	NOUN
biomedich-731	159	10	with	with	ADP
biomedich-731	159	11	drugs	drug	NOUN
biomedich-731	159	12	of	of	ADP
biomedich-731	159	13	dexamethasone	dexamethasone	NOUN
biomedich-731	159	14	/	/	SYM
biomedich-731	159	15	umifenovir	umifenovir	NUM
biomedich-731	159	16	by	by	ADP
biomedich-731	159	17	molecular	molecular	ADJ
biomedich-731	159	18	dynamics	dynamic	NOUN
biomedich-731	159	19	using	use	VERB
biomedich-731	159	20	opls	opls	PROPN
biomedich-731	159	21	-	-	PUNCT
biomedich-731	159	22	aa	aa	PROPN
biomedich-731	159	23	force	force	NOUN
biomedich-731	159	24	field	field	NOUN
biomedich-731	159	25	.	.	PUNCT
biomedich-731	160	1	research	research	NOUN
biomedich-731	160	2	on	on	ADP
biomedich-731	160	3	biomedical	biomedical	ADJ
biomedich-731	160	4	engineering	engineering	NOUN
biomedich-731	160	5	,	,	PUNCT
biomedich-731	160	6	1–10	1–10	NOUN
biomedich-731	160	7	.	.	PUNCT
biomedich-731	161	1	pantaleão	pantaleão	PROPN
biomedich-731	161	2	,	,	PUNCT
biomedich-731	161	3	s.	s.	PROPN
biomedich-731	161	4	q.	q.	PROPN
biomedich-731	161	5	,	,	PUNCT
biomedich-731	161	6	philot	philot	PROPN
biomedich-731	161	7	,	,	PUNCT
biomedich-731	161	8	e.	e.	PROPN
biomedich-731	161	9	a.	a.	PROPN
biomedich-731	161	10	,	,	PUNCT
biomedich-731	161	11	de	de	ADP
biomedich-731	161	12	resende	resende	NOUN
biomedich-731	161	13	-	-	PUNCT
biomedich-731	161	14	lara	lara	NOUN
biomedich-731	161	15	,	,	PUNCT
biomedich-731	161	16	p.	p.	PROPN
biomedich-731	161	17	t.	t.	PROPN
biomedich-731	161	18	,	,	PUNCT
biomedich-731	161	19	lima	lima	PROPN
biomedich-731	161	20	,	,	PUNCT
biomedich-731	161	21	a.	a.	NOUN
biomedich-731	161	22	n.	n.	NOUN
biomedich-731	161	23	,	,	PUNCT
biomedich-731	161	24	perahia	perahia	NOUN
biomedich-731	161	25	,	,	PUNCT
biomedich-731	161	26	d.	d.	PROPN
biomedich-731	161	27	,	,	PUNCT
biomedich-731	161	28	miteva	miteva	PROPN
biomedich-731	161	29	,	,	PUNCT
biomedich-731	161	30	m.	m.	NOUN
biomedich-731	161	31	a.	a.	PROPN
biomedich-731	161	32	,	,	PUNCT
biomedich-731	161	33	scott	scott	PROPN
biomedich-731	161	34	,	,	PUNCT
biomedich-731	161	35	a.	a.	PROPN
biomedich-731	161	36	l.	l.	PROPN
biomedich-731	161	37	,	,	PUNCT
biomedich-731	161	38	&	&	CCONJ
biomedich-731	161	39	honorio	honorio	PROPN
biomedich-731	161	40	,	,	PUNCT
biomedich-731	161	41	k.	k.	PROPN
biomedich-731	161	42	m.	m.	PROPN
biomedich-731	161	43	(	(	PUNCT
biomedich-731	161	44	2018	2018	NUM
biomedich-731	161	45	)	)	PUNCT
biomedich-731	161	46	.	.	PUNCT
biomedich-731	162	1	structural	structural	ADJ
biomedich-731	162	2	dynamics	dynamic	NOUN
biomedich-731	162	3	of	of	ADP
biomedich-731	162	4	dpp-4	dpp-4	ADJ
biomedich-731	162	5	and	and	CCONJ
biomedich-731	162	6	its	its	PRON
biomedich-731	162	7	influence	influence	NOUN
biomedich-731	162	8	on	on	ADP
biomedich-731	162	9	the	the	DET
biomedich-731	162	10	projection	projection	NOUN
biomedich-731	162	11	of	of	ADP
biomedich-731	162	12	bioactive	bioactive	ADJ
biomedich-731	162	13	ligands	ligand	NOUN
biomedich-731	162	14	.	.	PUNCT
biomedich-731	163	1	molecules	molecule	NOUN
biomedich-731	163	2	,	,	PUNCT
biomedich-731	163	3	23(2	23(2	NUM
biomedich-731	163	4	)	)	PUNCT
biomedich-731	163	5	,	,	PUNCT
biomedich-731	163	6	1–10	1–10	NOUN
biomedich-731	163	7	.	.	PUNCT
biomedich-731	164	1	samata	samata	PROPN
biomedich-731	164	2	,	,	PUNCT
biomedich-731	164	3	p.	p.	NOUN
biomedich-731	164	4	,	,	PUNCT
biomedich-731	164	5	gowa	gowa	PROPN
biomedich-731	164	6	,	,	PUNCT
biomedich-731	164	7	k.	k.	PROPN
biomedich-731	164	8	a.	a.	PROPN
biomedich-731	164	9	b.	b.	PROPN
biomedich-731	164	10	,	,	PUNCT
biomedich-731	164	11	munim	munim	PROPN
biomedich-731	164	12	,	,	PUNCT
biomedich-731	164	13	a.	a.	NOUN
biomedich-731	164	14	,	,	PUNCT
biomedich-731	164	15	alwi	alwi	NOUN
biomedich-731	164	16	,	,	PUNCT
biomedich-731	164	17	m.	m.	NOUN
biomedich-731	164	18	k.	k.	PROPN
biomedich-731	164	19	,	,	PUNCT
biomedich-731	164	20	&	&	CCONJ
biomedich-731	164	21	syam	syam	PROPN
biomedich-731	164	22	,	,	PUNCT
biomedich-731	164	23	a.	a.	NOUN
biomedich-731	164	24	(	(	PUNCT
biomedich-731	164	25	2019	2019	NUM
biomedich-731	164	26	)	)	PUNCT
biomedich-731	164	27	.	.	PUNCT
biomedich-731	165	1	pengaruh	pengaruh	PROPN
biomedich-731	165	2	pemberian	pemberian	PROPN
biomedich-731	165	3	tepung	tepung	PROPN
biomedich-731	165	4	daun	daun	PROPN
biomedich-731	165	5	kelor	kelor	PROPN
biomedich-731	165	6	terhadap	terhadap	PROPN
biomedich-731	165	7	penurunan	penurunan	PROPN
biomedich-731	165	8	glukosa	glukosa	PROPN
biomedich-731	165	9	darah	darah	PROPN
biomedich-731	165	10	pada	pada	PROPN
biomedich-731	165	11	penderita	penderita	PROPN
biomedich-731	165	12	diabetes	diabete	VERB
biomedich-731	165	13	di	di	NOUN
biomedich-731	165	14	wilayah	wilayah	PROPN
biomedich-731	165	15	kerja	kerja	PROPN
biomedich-731	165	16	puskesmas	puskesmas	PROPN
biomedich-731	165	17	samata	samata	PROPN
biomedich-731	165	18	kab	kab	PROPN
biomedich-731	165	19	.	.	PUNCT
biomedich-731	166	1	gowa	gowa	PROPN
biomedich-731	166	2	.	.	PUNCT
biomedich-731	167	1	jurnal	jurnal	PROPN
biomedich-731	167	2	ilmu	ilmu	PROPN
biomedich-731	167	3	kesehatan	kesehatan	PROPN
biomedich-731	167	4	diagnosis	diagnosis	PROPN
biomedich-731	167	5	,	,	PUNCT
biomedich-731	167	6	13(6	13(6	NUM
biomedich-731	167	7	)	)	PUNCT
biomedich-731	167	8	,	,	PUNCT
biomedich-731	167	9	605–611	605–611	NUM
biomedich-731	167	10	.	.	PUNCT
biomedich-731	168	1	setiawansyah	setiawansyah	PROPN
biomedich-731	168	2	,	,	PUNCT
biomedich-731	168	3	a.	a.	NOUN
biomedich-731	168	4	,	,	PUNCT
biomedich-731	168	5	reynaldi	reynaldi	NOUN
biomedich-731	168	6	,	,	PUNCT
biomedich-731	168	7	m.	m.	NOUN
biomedich-731	168	8	a.	a.	PROPN
biomedich-731	168	9	,	,	PUNCT
biomedich-731	168	10	tjahjono	tjahjono	ADV
biomedich-731	168	11	,	,	PUNCT
biomedich-731	168	12	d.	d.	PROPN
biomedich-731	168	13	h.	h.	PROPN
biomedich-731	168	14	,	,	PUNCT
biomedich-731	168	15	&	&	CCONJ
biomedich-731	168	16	sukrasno	sukrasno	PROPN
biomedich-731	168	17	,	,	PUNCT
biomedich-731	168	18	s.	s.	PROPN
biomedich-731	168	19	(	(	PUNCT
biomedich-731	168	20	2022	2022	NUM
biomedich-731	168	21	)	)	PUNCT
biomedich-731	168	22	.	.	PUNCT
biomedich-731	169	1	molecular	molecular	ADJ
biomedich-731	169	2	docking	docking	NOUN
biomedich-731	169	3	-	-	PUNCT
biomedich-731	169	4	based	base	VERB
biomedich-731	169	5	virtual	virtual	ADJ
biomedich-731	169	6	screening	screening	NOUN
biomedich-731	169	7	of	of	ADP
biomedich-731	169	8	antidiabetic	antidiabetic	ADJ
biomedich-731	169	9	agents	agent	NOUN
biomedich-731	169	10	from	from	ADP
biomedich-731	169	11	songga	songga	PROPN
biomedich-731	169	12	(	(	PUNCT
biomedich-731	169	13	strychnos	strychnos	PROPN
biomedich-731	169	14	lucida	lucida	PROPN
biomedich-731	169	15	r.br	r.br	PROPN
biomedich-731	169	16	.	.	PROPN
biomedich-731	169	17	):	):	PUNCT
biomedich-731	169	18	an	an	DET
biomedich-731	169	19	indonesian	indonesian	ADJ
biomedich-731	169	20	native	native	ADJ
biomedich-731	169	21	plant	plant	NOUN
biomedich-731	169	22	.	.	PUNCT
biomedich-731	170	1	current	current	ADJ
biomedich-731	170	2	research	research	NOUN
biomedich-731	170	3	on	on	ADP
biomedich-731	170	4	biosciences	bioscience	NOUN
biomedich-731	170	5	and	and	CCONJ
biomedich-731	170	6	biotechnology	biotechnology	NOUN
biomedich-731	170	7	,	,	PUNCT
biomedich-731	170	8	3(2	3(2	NUM
biomedich-731	170	9	)	)	PUNCT
biomedich-731	170	10	,	,	PUNCT
biomedich-731	170	11	208–214	208–214	NUM
biomedich-731	170	12	.	.	PUNCT
biomedich-731	171	1	suciana	suciana	PROPN
biomedich-731	171	2	,	,	PUNCT
biomedich-731	171	3	f.	f.	PROPN
biomedich-731	171	4	,	,	PUNCT
biomedich-731	171	5	&	&	CCONJ
biomedich-731	171	6	arifianto	arifianto	PROPN
biomedich-731	171	7	,	,	PUNCT
biomedich-731	171	8	d.	d.	PROPN
biomedich-731	171	9	(	(	PUNCT
biomedich-731	171	10	2019	2019	NUM
biomedich-731	171	11	)	)	PUNCT
biomedich-731	171	12	.	.	PUNCT
biomedich-731	172	1	penatalaksanaan	penatalaksanaan	PROPN
biomedich-731	172	2	5	5	NUM
biomedich-731	172	3	pilar	pilar	PROPN
biomedich-731	172	4	pengendalian	pengendalian	NOUN
biomedich-731	172	5	dm	dm	PROPN
biomedich-731	172	6	terhadap	terhadap	PROPN
biomedich-731	172	7	kualitas	kualitas	PROPN
biomedich-731	172	8	hidup	hidup	PROPN
biomedich-731	172	9	pasien	pasien	PROPN
biomedich-731	173	1	dm	dm	PROPN
biomedich-731	173	2	tipe	tipe	PROPN
biomedich-731	173	3	2	2	X
biomedich-731	173	4	.	.	PUNCT
biomedich-731	173	5	jurnal	jurnal	ADJ
biomedich-731	173	6	ilmiah	ilmiah	PROPN
biomedich-731	173	7	permas	permas	PROPN
biomedich-731	173	8	:	:	PUNCT
biomedich-731	173	9	jurnal	jurnal	ADJ
biomedich-731	173	10	ilmiah	ilmiah	PROPN
biomedich-731	173	11	stikes	stikes	PROPN
biomedich-731	173	12	kendal	kendal	PROPN
biomedich-731	173	13	,	,	PUNCT
biomedich-731	173	14	9(4	9(4	NUM
biomedich-731	173	15	)	)	PUNCT
biomedich-731	173	16	,	,	PUNCT
biomedich-731	173	17	311–318	311–318	NUM
biomedich-731	173	18	.	.	PUNCT
biomedich-731	174	1	suhadi	suhadi	PROPN
biomedich-731	174	2	,	,	PUNCT
biomedich-731	174	3	a.	a.	NOUN
biomedich-731	174	4	,	,	PUNCT
biomedich-731	174	5	rizarullah	rizarullah	PROPN
biomedich-731	174	6	,	,	PUNCT
biomedich-731	174	7	r.	r.	PROPN
biomedich-731	174	8	,	,	PUNCT
biomedich-731	174	9	&	&	CCONJ
biomedich-731	174	10	feriyani	feriyani	PROPN
biomedich-731	174	11	,	,	PUNCT
biomedich-731	174	12	f.	f.	PROPN
biomedich-731	174	13	(	(	PUNCT
biomedich-731	174	14	2019	2019	NUM
biomedich-731	174	15	)	)	PUNCT
biomedich-731	174	16	.	.	PUNCT
biomedich-731	175	1	simulasi	simulasi	NOUN
biomedich-731	175	2	docking	dock	VERB
biomedich-731	175	3	senyawa	senyawa	PROPN
biomedich-731	175	4	aktif	aktif	PROPN
biomedich-731	175	5	daun	daun	PROPN
biomedich-731	175	6	binahong	binahong	PROPN
biomedich-731	175	7	sebagai	sebagai	PROPN
biomedich-731	175	8	inhibitor	inhibitor	NOUN
biomedich-731	175	9	enzyme	enzyme	NOUN
biomedich-731	175	10	aldose	aldose	ADJ
biomedich-731	175	11	reductase	reductase	NOUN
biomedich-731	175	12	.	.	PUNCT
biomedich-731	176	1	sel	sel	PROPN
biomedich-731	176	2	jurnal	jurnal	ADJ
biomedich-731	176	3	penelitian	penelitian	PROPN
biomedich-731	176	4	kesehatan	kesehatan	PROPN
biomedich-731	176	5	,	,	PUNCT
biomedich-731	176	6	6(2	6(2	NUM
biomedich-731	176	7	)	)	PUNCT
biomedich-731	176	8	,	,	PUNCT
biomedich-731	176	9	55–65	55–65	NUM
biomedich-731	176	10	.	.	PUNCT
biomedich-731	177	1	xiao	xiao	PROPN
biomedich-731	177	2	,	,	PUNCT
biomedich-731	177	3	w.	w.	PROPN
biomedich-731	177	4	,	,	PUNCT
biomedich-731	177	5	wang	wang	PROPN
biomedich-731	177	6	,	,	PUNCT
biomedich-731	177	7	d.	d.	PROPN
biomedich-731	177	8	,	,	PUNCT
biomedich-731	177	9	shen	shen	PROPN
biomedich-731	177	10	,	,	PUNCT
biomedich-731	177	11	z.	z.	PROPN
biomedich-731	177	12	,	,	PUNCT
biomedich-731	177	13	li	li	PROPN
biomedich-731	177	14	,	,	PUNCT
biomedich-731	177	15	s.	s.	PROPN
biomedich-731	177	16	,	,	PUNCT
biomedich-731	177	17	&	&	CCONJ
biomedich-731	177	18	li	li	PROPN
biomedich-731	177	19	,	,	PUNCT
biomedich-731	177	20	h.	h.	PROPN
biomedich-731	177	21	(	(	PUNCT
biomedich-731	177	22	2018	2018	NUM
biomedich-731	177	23	)	)	PUNCT
biomedich-731	177	24	.	.	PUNCT
biomedich-731	178	1	multi	multi	ADJ
biomedich-731	178	2	-	-	ADJ
biomedich-731	178	3	body	body	ADJ
biomedich-731	178	4	interactions	interaction	NOUN
biomedich-731	178	5	in	in	ADP
biomedich-731	178	6	molecular	molecular	ADJ
biomedich-731	178	7	docking	docking	NOUN
biomedich-731	178	8	program	program	NOUN
biomedich-731	178	9	devised	devise	VERB
biomedich-731	178	10	with	with	ADP
biomedich-731	178	11	key	key	ADJ
biomedich-731	178	12	water	water	NOUN
biomedich-731	178	13	molecules	molecule	NOUN
biomedich-731	178	14	in	in	ADP
biomedich-731	178	15	protein	protein	NOUN
biomedich-731	178	16	binding	bind	VERB
biomedich-731	178	17	sites	site	NOUN
biomedich-731	178	18	.	.	PUNCT
biomedich-731	179	1	molecules	molecule	NOUN
biomedich-731	179	2	,	,	PUNCT
biomedich-731	179	3	23(9	23(9	NUM
biomedich-731	179	4	)	)	PUNCT
biomedich-731	179	5	,	,	PUNCT
biomedich-731	179	6	1	1	NUM
biomedich-731	179	7	–	–	PUNCT
biomedich-731	179	8	24	24	NUM
biomedich-731	179	9	.	.	PUNCT
biomedich-731	180	1	yuan	yuan	NOUN
biomedich-731	180	2	,	,	PUNCT
biomedich-731	180	3	y.	y.	PROPN
biomedich-731	180	4	,	,	PUNCT
biomedich-731	180	5	win	win	VERB
biomedich-731	180	6	aung	aung	PROPN
biomedich-731	180	7	,	,	PUNCT
biomedich-731	180	8	k.	k.	PROPN
biomedich-731	180	9	k.	k.	PROPN
biomedich-731	180	10	,	,	PUNCT
biomedich-731	180	11	ran	run	VERB
biomedich-731	180	12	,	,	PUNCT
biomedich-731	180	13	x.	x.	PROPN
biomedich-731	180	14	,	,	PUNCT
biomedich-731	180	15	wang	wang	PROPN
biomedich-731	180	16	,	,	PUNCT
biomedich-731	180	17	x.	x.	PROPN
biomedich-731	180	18	,	,	PUNCT
biomedich-731	180	19	dou	dou	PROPN
biomedich-731	180	20	,	,	PUNCT
biomedich-731	180	21	d.	d.	PROPN
biomedich-731	180	22	,	,	PUNCT
biomedich-731	180	23	&	&	CCONJ
biomedich-731	180	24	dong	dong	PROPN
biomedich-731	180	25	,	,	PUNCT
biomedich-731	180	26	f.	f.	PROPN
biomedich-731	180	27	(	(	PUNCT
biomedich-731	180	28	2017	2017	NUM
biomedich-731	180	29	)	)	PUNCT
biomedich-731	180	30	.	.	PUNCT
biomedich-731	181	1	a	a	DET
biomedich-731	181	2	new	new	ADJ
biomedich-731	181	3	sesquiterpene	sesquiterpene	NOUN
biomedich-731	181	4	lactone	lactone	NOUN
biomedich-731	181	5	from	from	ADP
biomedich-731	181	6	yacon	yacon	NOUN
biomedich-731	181	7	leaves	leave	NOUN
biomedich-731	181	8	.	.	PUNCT
biomedich-731	182	1	natural	natural	ADJ
biomedich-731	182	2	product	product	NOUN
biomedich-731	182	3	research	research	NOUN
biomedich-731	182	4	,	,	PUNCT
biomedich-731	182	5	31(1	31(1	NUM
biomedich-731	182	6	)	)	PUNCT
biomedich-731	182	7	,	,	PUNCT
biomedich-731	182	8	43–49	43–49	PROPN
biomedich-731	182	9	.	.	PUNCT
biomedich-731	183	1	this	this	DET
biomedich-731	183	2	page	page	NOUN
biomedich-731	183	3	intentionally	intentionally	ADV
biomedich-731	183	4	left	leave	VERB
biomedich-731	183	5	blank	blank	ADV