id	sid	tid	token	lemma	pos
biomedich-811	1	1	biology	biology	NOUN
biomedich-811	1	2	,	,	PUNCT
biomedich-811	1	3	medicine	medicine	NOUN
biomedich-811	1	4	,	,	PUNCT
biomedich-811	1	5	&	&	CCONJ
biomedich-811	1	6	natural	natural	ADJ
biomedich-811	1	7	product	product	NOUN
biomedich-811	1	8	chemistry	chemistry	NOUN
biomedich-811	1	9	issn	issn	VERB
biomedich-811	1	10	2089	2089	NUM
biomedich-811	1	11	-	-	SYM
biomedich-811	1	12	6514	6514	NUM
biomedich-811	1	13	(	(	PUNCT
biomedich-811	1	14	paper	paper	NOUN
biomedich-811	1	15	)	)	PUNCT
biomedich-811	1	16	volume	volume	NOUN
biomedich-811	1	17	14	14	NUM
biomedich-811	1	18	,	,	PUNCT
biomedich-811	1	19	number	number	NOUN
biomedich-811	1	20	2	2	NUM
biomedich-811	1	21	,	,	PUNCT
biomedich-811	1	22	october	october	PROPN
biomedich-811	1	23	2025	2025	NUM
biomedich-811	1	24	|	|	ADV
biomedich-811	1	25	pages	page	NOUN
biomedich-811	1	26	:	:	PUNCT
biomedich-811	1	27	673	673	NUM
biomedich-811	1	28	-	-	SYM
biomedich-811	1	29	678	678	NUM
biomedich-811	1	30	|	|	ADV
biomedich-811	1	31	doi	doi	NOUN
biomedich-811	1	32	:	:	PUNCT
biomedich-811	1	33	10.14421	10.14421	NUM
biomedich-811	1	34	/	/	SYM
biomedich-811	1	35	biomedich.2025.142.673	biomedich.2025.142.673	NOUN
biomedich-811	1	36	-	-	PUNCT
biomedich-811	1	37	678	678	NUM
biomedich-811	1	38	issn	issn	PROPN
biomedich-811	1	39	2540	2540	NUM
biomedich-811	1	40	-	-	SYM
biomedich-811	1	41	9328	9328	NUM
biomedich-811	1	42	(	(	PUNCT
biomedich-811	1	43	online	online	ADJ
biomedich-811	1	44	)	)	PUNCT
biomedich-811	1	45	molecular	molecular	ADJ
biomedich-811	1	46	method	method	NOUN
biomedich-811	1	47	optimization	optimization	NOUN
biomedich-811	1	48	to	to	PART
biomedich-811	1	49	identify	identify	VERB
biomedich-811	1	50	plasmodium	plasmodium	NOUN
biomedich-811	1	51	falciparum	falciparum	NOUN
biomedich-811	1	52	multidrug	multidrug	NOUN
biomedich-811	1	53	resistance	resistance	NOUN
biomedich-811	1	54	1	1	NUM
biomedich-811	1	55	(	(	PUNCT
biomedich-811	1	56	pfmdr1	pfmdr1	NOUN
biomedich-811	1	57	)	)	PUNCT
biomedich-811	1	58	gene	gene	NOUN
biomedich-811	1	59	as	as	ADP
biomedich-811	1	60	a	a	DET
biomedich-811	1	61	predictor	predictor	NOUN
biomedich-811	1	62	of	of	ADP
biomedich-811	1	63	antimalarial	antimalarial	ADJ
biomedich-811	1	64	resistance	resistance	NOUN
biomedich-811	1	65	erma	erma	PROPN
biomedich-811	1	66	sulistyaningsih1	sulistyaningsih1	PROPN
biomedich-811	1	67	,	,	PUNCT
biomedich-811	1	68	*	*	PUNCT
biomedich-811	1	69	,	,	PUNCT
biomedich-811	1	70	rosita	rosita	PROPN
biomedich-811	1	71	dewi2	dewi2	PROPN
biomedich-811	1	72	,	,	PUNCT
biomedich-811	1	73	sheilla	sheilla	PROPN
biomedich-811	1	74	rachmania2	rachmania2	PROPN
biomedich-811	1	75	,	,	PUNCT
biomedich-811	1	76	irawan	irawan	PROPN
biomedich-811	1	77	fajar	fajar	PROPN
biomedich-811	1	78	kusuma3	kusuma3	PROPN
biomedich-811	1	79	,	,	PUNCT
biomedich-811	1	80	muhammad	muhammad	PROPN
biomedich-811	1	81	rizqi	rizqi	NOUN
biomedich-811	1	82	kholifaturrohmy4	kholifaturrohmy4	PROPN
biomedich-811	1	83	,	,	PUNCT
biomedich-811	1	84	yunita	yunita	PROPN
biomedich-811	1	85	armiyanti1	armiyanti1	NOUN
biomedich-811	1	86	,	,	PUNCT
biomedich-811	1	87	sakinatus	sakinatus	PROPN
biomedich-811	1	88	sariroh	sariroh	PROPN
biomedich-811	1	89	kholifaturrohmah1	kholifaturrohmah1	PROPN
biomedich-811	1	90	,	,	PUNCT
biomedich-811	1	91	made	make	VERB
biomedich-811	1	92	prasanti	prasanti	NOUN
biomedich-811	1	93	andriani1	andriani1	PROPN
biomedich-811	1	94	1parasitology	1parasitology	PROPN
biomedich-811	1	95	department	department	NOUN
biomedich-811	1	96	;	;	PUNCT
biomedich-811	1	97	2histology	2histology	PROPN
biomedich-811	1	98	department	department	NOUN
biomedich-811	1	99	;	;	PUNCT
biomedich-811	1	100	3public	3public	NUM
biomedich-811	1	101	health	health	NOUN
biomedich-811	1	102	department	department	NOUN
biomedich-811	1	103	,	,	PUNCT
biomedich-811	1	104	faculty	faculty	NOUN
biomedich-811	1	105	of	of	ADP
biomedich-811	1	106	medicine	medicine	NOUN
biomedich-811	1	107	,	,	PUNCT
biomedich-811	1	108	university	university	NOUN
biomedich-811	1	109	of	of	ADP
biomedich-811	1	110	jember	jember	PROPN
biomedich-811	1	111	,	,	PUNCT
biomedich-811	1	112	jl	jl	PROPN
biomedich-811	1	113	.	.	PROPN
biomedich-811	1	114	kalimantan	kalimantan	PROPN
biomedich-811	2	1	no	no	DET
biomedich-811	2	2	37	37	NUM
biomedich-811	2	3	jember	jember	NOUN
biomedich-811	2	4	68121	68121	NUM
biomedich-811	2	5	,	,	PUNCT
biomedich-811	2	6	tel	tel	PROPN
biomedich-811	2	7	.	.	PUNCT
biomedich-811	2	8	+62	+62	PROPN
biomedich-811	2	9	-	-	PUNCT
biomedich-811	2	10	331	331	NUM
biomedich-811	2	11	-	-	PUNCT
biomedich-811	2	12	337877	337877	NUM
biomedich-811	2	13	,	,	PUNCT
biomedich-811	2	14	fax	fax	NOUN
biomedich-811	2	15	.	.	PUNCT
biomedich-811	2	16	+62	+62	PROPN
biomedich-811	2	17	-	-	PUNCT
biomedich-811	2	18	331	331	NUM
biomedich-811	2	19	-	-	PUNCT
biomedich-811	2	20	337877	337877	NUM
biomedich-811	2	21	,	,	PUNCT
biomedich-811	2	22	indonesia	indonesia	PROPN
biomedich-811	2	23	.	.	PUNCT
biomedich-811	3	1	4satgas	4satgas	NUM
biomedich-811	3	2	pamtas	pamtas	ADJ
biomedich-811	3	3	statis	statis	PROPN
biomedich-811	3	4	ri	ri	PROPN
biomedich-811	3	5	-	-	PUNCT
biomedich-811	3	6	png	png	PROPN
biomedich-811	3	7	t.a	t.a	PROPN
biomedich-811	3	8	.	.	PROPN
biomedich-811	3	9	2023	2023	NUM
biomedich-811	3	10	yonif	yonif	NOUN
biomedich-811	3	11	122	122	NUM
biomedich-811	3	12	/	/	SYM
biomedich-811	3	13	tombak	tombak	PROPN
biomedich-811	3	14	sakti	sakti	PROPN
biomedich-811	3	15	,	,	PUNCT
biomedich-811	3	16	keerom	keerom	NOUN
biomedich-811	3	17	,	,	PUNCT
biomedich-811	3	18	papua	papua	PROPN
biomedich-811	3	19	,	,	PUNCT
biomedich-811	3	20	99451	99451	NUM
biomedich-811	3	21	,	,	PUNCT
biomedich-811	3	22	indonesia	indonesia	PROPN
biomedich-811	3	23	.	.	PUNCT
biomedich-811	4	1	corresponding	correspond	VERB
biomedich-811	4	2	author	author	NOUN
biomedich-811	4	3	*	*	PROPN
biomedich-811	4	4	sulistyaningsih.fk@unej.ac.id	sulistyaningsih.fk@unej.ac.id	NOUN
biomedich-811	4	5	manuscript	manuscript	NOUN
biomedich-811	4	6	received	receive	VERB
biomedich-811	4	7	:	:	PUNCT
biomedich-811	4	8	26	26	NUM
biomedich-811	4	9	may	may	NOUN
biomedich-811	4	10	,	,	PUNCT
biomedich-811	4	11	2025	2025	NUM
biomedich-811	4	12	.	.	PUNCT
biomedich-811	5	1	revision	revision	NOUN
biomedich-811	5	2	accepted	accept	VERB
biomedich-811	5	3	:	:	PUNCT
biomedich-811	5	4	04	04	NUM
biomedich-811	5	5	september	september	PROPN
biomedich-811	5	6	,	,	PUNCT
biomedich-811	5	7	2025	2025	NUM
biomedich-811	5	8	.	.	PUNCT
biomedich-811	6	1	published	publish	VERB
biomedich-811	6	2	:	:	PUNCT
biomedich-811	6	3	01	01	NUM
biomedich-811	6	4	october	october	PROPN
biomedich-811	6	5	,	,	PUNCT
biomedich-811	6	6	2025	2025	NUM
biomedich-811	6	7	.	.	PUNCT
biomedich-811	7	1	abstract	abstract	ADJ
biomedich-811	7	2	several	several	ADJ
biomedich-811	7	3	approaches	approach	NOUN
biomedich-811	7	4	have	have	AUX
biomedich-811	7	5	been	be	AUX
biomedich-811	7	6	designed	design	VERB
biomedich-811	7	7	to	to	PART
biomedich-811	7	8	control	control	VERB
biomedich-811	7	9	malaria	malaria	NOUN
biomedich-811	7	10	,	,	PUNCT
biomedich-811	7	11	a	a	DET
biomedich-811	7	12	disease	disease	NOUN
biomedich-811	7	13	with	with	ADP
biomedich-811	7	14	high	high	ADJ
biomedich-811	7	15	morbidity	morbidity	NOUN
biomedich-811	7	16	and	and	CCONJ
biomedich-811	7	17	mortality	mortality	NOUN
biomedich-811	7	18	,	,	PUNCT
biomedich-811	7	19	but	but	CCONJ
biomedich-811	7	20	they	they	PRON
biomedich-811	7	21	face	face	VERB
biomedich-811	7	22	some	some	DET
biomedich-811	7	23	hurdles	hurdle	NOUN
biomedich-811	7	24	.	.	PUNCT
biomedich-811	8	1	antimalarial	antimalarial	ADJ
biomedich-811	8	2	resistance	resistance	NOUN
biomedich-811	8	3	is	be	AUX
biomedich-811	8	4	one	one	NUM
biomedich-811	8	5	of	of	ADP
biomedich-811	8	6	the	the	DET
biomedich-811	8	7	major	major	ADJ
biomedich-811	8	8	challenges	challenge	NOUN
biomedich-811	8	9	for	for	ADP
biomedich-811	8	10	malaria	malaria	NOUN
biomedich-811	8	11	elimination	elimination	NOUN
biomedich-811	8	12	,	,	PUNCT
biomedich-811	8	13	so	so	CCONJ
biomedich-811	8	14	the	the	DET
biomedich-811	8	15	detection	detection	NOUN
biomedich-811	8	16	of	of	ADP
biomedich-811	8	17	antimalarial	antimalarial	ADJ
biomedich-811	8	18	resistance	resistance	NOUN
biomedich-811	8	19	is	be	AUX
biomedich-811	8	20	essential	essential	ADJ
biomedich-811	8	21	.	.	PUNCT
biomedich-811	9	1	several	several	ADJ
biomedich-811	9	2	molecular	molecular	ADJ
biomedich-811	9	3	markers	marker	NOUN
biomedich-811	9	4	for	for	ADP
biomedich-811	9	5	antimalarial	antimalarial	ADJ
biomedich-811	9	6	resistance	resistance	NOUN
biomedich-811	9	7	have	have	AUX
biomedich-811	9	8	been	be	AUX
biomedich-811	9	9	identified	identify	VERB
biomedich-811	9	10	,	,	PUNCT
biomedich-811	9	11	including	include	VERB
biomedich-811	9	12	plasmodium	plasmodium	NOUN
biomedich-811	9	13	falciparum	falciparum	ADJ
biomedich-811	9	14	multidrug	multidrug	NOUN
biomedich-811	9	15	resistance	resistance	NOUN
biomedich-811	9	16	1	1	NUM
biomedich-811	9	17	(	(	PUNCT
biomedich-811	9	18	pfmdr1	pfmdr1	NOUN
biomedich-811	9	19	)	)	PUNCT
biomedich-811	9	20	gene	gene	NOUN
biomedich-811	9	21	.	.	PUNCT
biomedich-811	10	1	this	this	DET
biomedich-811	10	2	study	study	NOUN
biomedich-811	10	3	determined	determine	VERB
biomedich-811	10	4	the	the	DET
biomedich-811	10	5	optimization	optimization	NOUN
biomedich-811	10	6	of	of	ADP
biomedich-811	10	7	molecular	molecular	ADJ
biomedich-811	10	8	techniques	technique	NOUN
biomedich-811	10	9	to	to	PART
biomedich-811	10	10	identify	identify	VERB
biomedich-811	10	11	the	the	DET
biomedich-811	10	12	pfmdr1	pfmdr1	NOUN
biomedich-811	10	13	gene	gene	NOUN
biomedich-811	10	14	as	as	ADP
biomedich-811	10	15	an	an	DET
biomedich-811	10	16	antimalarial	antimalarial	ADJ
biomedich-811	10	17	resistance	resistance	NOUN
biomedich-811	10	18	predictor	predictor	NOUN
biomedich-811	10	19	in	in	ADP
biomedich-811	10	20	indonesia	indonesia	PROPN
biomedich-811	10	21	.	.	PUNCT
biomedich-811	11	1	the	the	DET
biomedich-811	11	2	study	study	NOUN
biomedich-811	11	3	included	include	VERB
biomedich-811	11	4	patients	patient	NOUN
biomedich-811	11	5	diagnosed	diagnose	VERB
biomedich-811	11	6	with	with	ADP
biomedich-811	11	7	uncomplicated	uncomplicated	ADJ
biomedich-811	11	8	or	or	CCONJ
biomedich-811	11	9	severe	severe	ADJ
biomedich-811	11	10	malaria	malaria	NOUN
biomedich-811	11	11	originating	originate	VERB
biomedich-811	11	12	from	from	ADP
biomedich-811	11	13	the	the	DET
biomedich-811	11	14	health	health	NOUN
biomedich-811	11	15	district	district	NOUN
biomedich-811	11	16	of	of	ADP
biomedich-811	11	17	kerom	kerom	PROPN
biomedich-811	11	18	regency	regency	PROPN
biomedich-811	11	19	,	,	PUNCT
biomedich-811	11	20	papua	papua	PROPN
biomedich-811	11	21	province	province	PROPN
biomedich-811	11	22	,	,	PUNCT
biomedich-811	11	23	and	and	CCONJ
biomedich-811	11	24	dr	dr	PROPN
biomedich-811	11	25	.	.	PROPN
biomedich-811	11	26	soebandi	soebandi	PROPN
biomedich-811	11	27	hospital	hospital	PROPN
biomedich-811	11	28	,	,	PUNCT
biomedich-811	11	29	jember	jember	PROPN
biomedich-811	11	30	,	,	PUNCT
biomedich-811	11	31	east	east	PROPN
biomedich-811	11	32	java	java	PROPN
biomedich-811	11	33	province	province	PROPN
biomedich-811	11	34	.	.	PUNCT
biomedich-811	12	1	blood	blood	NOUN
biomedich-811	12	2	samples	sample	NOUN
biomedich-811	12	3	were	be	AUX
biomedich-811	12	4	collected	collect	VERB
biomedich-811	12	5	in	in	ADP
biomedich-811	12	6	the	the	DET
biomedich-811	12	7	whatmann	whatmann	NOUN
biomedich-811	12	8	filer	filer	NOUN
biomedich-811	12	9	paper	paper	NOUN
biomedich-811	12	10	after	after	ADP
biomedich-811	12	11	informed	informed	ADJ
biomedich-811	12	12	consent	consent	NOUN
biomedich-811	12	13	.	.	PUNCT
biomedich-811	13	1	dna	dna	PROPN
biomedich-811	13	2	was	be	AUX
biomedich-811	13	3	isolated	isolate	VERB
biomedich-811	13	4	from	from	ADP
biomedich-811	13	5	dried	dry	VERB
biomedich-811	13	6	blood	blood	NOUN
biomedich-811	13	7	filter	filter	NOUN
biomedich-811	13	8	paper	paper	NOUN
biomedich-811	13	9	,	,	PUNCT
biomedich-811	13	10	and	and	CCONJ
biomedich-811	13	11	nested	nest	VERB
biomedich-811	13	12	pcr	pcr	NOUN
biomedich-811	13	13	was	be	AUX
biomedich-811	13	14	performed	perform	VERB
biomedich-811	13	15	using	use	VERB
biomedich-811	13	16	a	a	DET
biomedich-811	13	17	specific	specific	ADJ
biomedich-811	13	18	primer	primer	NOUN
biomedich-811	13	19	,	,	PUNCT
biomedich-811	13	20	the	the	DET
biomedich-811	13	21	pfmdr1	pfmdr1	PROPN
biomedich-811	13	22	-	-	PUNCT
biomedich-811	13	23	a	a	PROPN
biomedich-811	13	24	and	and	CCONJ
biomedich-811	13	25	pfmdr1	pfmdr1	PROPN
biomedich-811	13	26	-	-	PUNCT
biomedich-811	13	27	b	b	NOUN
biomedich-811	13	28	genes	gene	NOUN
biomedich-811	13	29	.	.	PUNCT
biomedich-811	14	1	the	the	DET
biomedich-811	14	2	pcr	pcr	ADJ
biomedich-811	14	3	cycle	cycle	NOUN
biomedich-811	14	4	was	be	AUX
biomedich-811	14	5	optimized	optimize	VERB
biomedich-811	14	6	based	base	VERB
biomedich-811	14	7	on	on	ADP
biomedich-811	14	8	previous	previous	ADJ
biomedich-811	14	9	studies	study	NOUN
biomedich-811	14	10	.	.	PUNCT
biomedich-811	15	1	the	the	DET
biomedich-811	15	2	pfmdr1	pfmdr1	PROPN
biomedich-811	15	3	-	-	PUNCT
biomedich-811	15	4	a	a	PROPN
biomedich-811	15	5	has	have	VERB
biomedich-811	15	6	a	a	DET
biomedich-811	15	7	similar	similar	ADJ
biomedich-811	15	8	setting	setting	NOUN
biomedich-811	15	9	to	to	ADP
biomedich-811	15	10	the	the	DET
biomedich-811	15	11	earlier	early	ADJ
biomedich-811	15	12	study	study	NOUN
biomedich-811	15	13	,	,	PUNCT
biomedich-811	15	14	but	but	CCONJ
biomedich-811	15	15	the	the	DET
biomedich-811	15	16	pfmdr1	pfmdr1	PROPN
biomedich-811	15	17	-	-	PUNCT
biomedich-811	15	18	b	b	PROPN
biomedich-811	15	19	had	have	VERB
biomedich-811	15	20	a	a	DET
biomedich-811	15	21	different	different	ADJ
biomedich-811	15	22	optimum	optimum	ADJ
biomedich-811	15	23	setting	setting	NOUN
biomedich-811	15	24	from	from	ADP
biomedich-811	15	25	the	the	DET
biomedich-811	15	26	previous	previous	ADJ
biomedich-811	15	27	study	study	NOUN
biomedich-811	15	28	with	with	ADP
biomedich-811	15	29	the	the	DET
biomedich-811	15	30	annealing	anneal	VERB
biomedich-811	15	31	temperature	temperature	NOUN
biomedich-811	15	32	of	of	ADP
biomedich-811	15	33	57oc	57oc	NOUN
biomedich-811	15	34	for	for	ADP
biomedich-811	15	35	nested-1	nested-1	NUM
biomedich-811	15	36	and	and	CCONJ
biomedich-811	15	37	62oc	62oc	NOUN
biomedich-811	15	38	for	for	ADP
biomedich-811	15	39	nested-2	nested-2	NOUN
biomedich-811	15	40	.	.	PUNCT
biomedich-811	16	1	this	this	DET
biomedich-811	16	2	pcr	pcr	NOUN
biomedich-811	16	3	setting	setting	NOUN
biomedich-811	16	4	could	could	AUX
biomedich-811	16	5	be	be	AUX
biomedich-811	16	6	used	use	VERB
biomedich-811	16	7	for	for	ADP
biomedich-811	16	8	further	further	ADJ
biomedich-811	16	9	examination	examination	NOUN
biomedich-811	16	10	.	.	PUNCT
biomedich-811	17	1	the	the	DET
biomedich-811	17	2	positive	positive	ADJ
biomedich-811	17	3	results	result	NOUN
biomedich-811	17	4	of	of	ADP
biomedich-811	17	5	the	the	DET
biomedich-811	17	6	amplification	amplification	NOUN
biomedich-811	17	7	indicated	indicate	VERB
biomedich-811	17	8	the	the	DET
biomedich-811	17	9	potential	potential	NOUN
biomedich-811	17	10	for	for	ADP
biomedich-811	17	11	antimalarial	antimalarial	ADJ
biomedich-811	17	12	resistance	resistance	NOUN
biomedich-811	17	13	in	in	ADP
biomedich-811	17	14	the	the	DET
biomedich-811	17	15	parasite	parasite	ADJ
biomedich-811	17	16	population	population	NOUN
biomedich-811	17	17	.	.	PUNCT
biomedich-811	18	1	a	a	DET
biomedich-811	18	2	study	study	NOUN
biomedich-811	18	3	on	on	ADP
biomedich-811	18	4	the	the	DET
biomedich-811	18	5	gene	gene	NOUN
biomedich-811	18	6	copy	copy	NOUN
biomedich-811	18	7	number	number	NOUN
biomedich-811	18	8	and	and	CCONJ
biomedich-811	18	9	polymorphism	polymorphism	NOUN
biomedich-811	18	10	is	be	AUX
biomedich-811	18	11	essential	essential	ADJ
biomedich-811	18	12	to	to	PART
biomedich-811	18	13	determine	determine	VERB
biomedich-811	18	14	the	the	DET
biomedich-811	18	15	definitive	definitive	ADJ
biomedich-811	18	16	conclusion	conclusion	NOUN
biomedich-811	18	17	on	on	ADP
biomedich-811	18	18	antimalarial	antimalarial	ADJ
biomedich-811	18	19	resistance	resistance	NOUN
biomedich-811	18	20	.	.	PUNCT
biomedich-811	19	1	keywords	keyword	NOUN
biomedich-811	19	2	:	:	PUNCT
biomedich-811	19	3	gene	gene	NOUN
biomedich-811	19	4	;	;	PUNCT
biomedich-811	19	5	malaria	malaria	NOUN
biomedich-811	19	6	;	;	PUNCT
biomedich-811	19	7	pfmdr1	pfmdr1	PROPN
biomedich-811	19	8	;	;	PUNCT
biomedich-811	19	9	plasmodium	plasmodium	NOUN
biomedich-811	19	10	falciparum	falciparum	NOUN
biomedich-811	19	11	;	;	PUNCT
biomedich-811	19	12	resistance	resistance	NOUN
biomedich-811	19	13	.	.	PUNCT
biomedich-811	20	1	abbreviations	abbreviation	NOUN
biomedich-811	20	2	:	:	PUNCT
biomedich-811	20	3	act	act	NOUN
biomedich-811	20	4	:	:	PUNCT
biomedich-811	20	5	artemisinin	artemisinin	NOUN
biomedich-811	20	6	-	-	PUNCT
biomedich-811	20	7	based	base	VERB
biomedich-811	20	8	combination	combination	NOUN
biomedich-811	20	9	therapy	therapy	NOUN
biomedich-811	20	10	;	;	PUNCT
biomedich-811	20	11	aq	aq	NUM
biomedich-811	20	12	:	:	PUNCT
biomedich-811	20	13	amodiaquine	amodiaquine	PROPN
biomedich-811	20	14	;	;	PUNCT
biomedich-811	20	15	cnvs	cnvs	NOUN
biomedich-811	20	16	:	:	PUNCT
biomedich-811	20	17	copy	copy	NOUN
biomedich-811	20	18	-	-	PUNCT
biomedich-811	20	19	number	number	NOUN
biomedich-811	20	20	variations	variation	NOUN
biomedich-811	20	21	;	;	PUNCT
biomedich-811	20	22	cq	cq	NUM
biomedich-811	20	23	:	:	PUNCT
biomedich-811	20	24	chloroquine	chloroquine	NOUN
biomedich-811	20	25	;	;	PUNCT
biomedich-811	20	26	dna	dna	PROPN
biomedich-811	20	27	:	:	PUNCT
biomedich-811	20	28	deoxyribonucleic	deoxyribonucleic	ADJ
biomedich-811	20	29	acid	acid	NOUN
biomedich-811	20	30	;	;	PUNCT
biomedich-811	20	31	pcr	pcr	ADJ
biomedich-811	20	32	:	:	PUNCT
biomedich-811	20	33	polymerase	polymerase	NOUN
biomedich-811	20	34	chain	chain	NOUN
biomedich-811	20	35	reaction	reaction	NOUN
biomedich-811	20	36	;	;	PUNCT
biomedich-811	20	37	pfcrt	pfcrt	ADJ
biomedich-811	20	38	:	:	PUNCT
biomedich-811	20	39	plasmodium	plasmodium	NOUN
biomedich-811	20	40	falciparum	falciparum	ADJ
biomedich-811	20	41	chloroquine	chloroquine	NOUN
biomedich-811	20	42	-	-	PUNCT
biomedich-811	20	43	resistance	resistance	NOUN
biomedich-811	20	44	transporter	transporter	NOUN
biomedich-811	20	45	;	;	PUNCT
biomedich-811	20	46	pfmdr1	pfmdr1	PROPN
biomedich-811	20	47	:	:	PUNCT
biomedich-811	21	1	plasmodium	plasmodium	NOUN
biomedich-811	21	2	falciparum	falciparum	ADJ
biomedich-811	21	3	multidrug	multidrug	NOUN
biomedich-811	21	4	resistance	resistance	NOUN
biomedich-811	21	5	1	1	NUM
biomedich-811	21	6	;	;	PUNCT
biomedich-811	21	7	snps	snps	PROPN
biomedich-811	21	8	:	:	PUNCT
biomedich-811	21	9	single	single	ADJ
biomedich-811	21	10	nucleotide	nucleotide	ADJ
biomedich-811	21	11	polymorphisms	polymorphism	NOUN
biomedich-811	21	12	;	;	PUNCT
biomedich-811	21	13	sp	sp	NOUN
biomedich-811	21	14	:	:	PUNCT
biomedich-811	21	15	sulfadoxine	sulfadoxine	ADJ
biomedich-811	21	16	-	-	PUNCT
biomedich-811	21	17	pyrimethamine	pyrimethamine	NOUN
biomedich-811	21	18	;	;	PUNCT
biomedich-811	21	19	tes	tes	NOUN
biomedich-811	21	20	:	:	PUNCT
biomedich-811	21	21	therapeutic	therapeutic	ADJ
biomedich-811	21	22	efficacy	efficacy	NOUN
biomedich-811	21	23	studies	study	NOUN
biomedich-811	21	24	;	;	PUNCT
biomedich-811	21	25	who	who	PRON
biomedich-811	21	26	:	:	PUNCT
biomedich-811	21	27	world	world	PROPN
biomedich-811	21	28	health	health	PROPN
biomedich-811	21	29	organization	organization	PROPN
biomedich-811	21	30	.	.	PUNCT
biomedich-811	22	1	introduction	introduction	NOUN
biomedich-811	22	2	malaria	malaria	NOUN
biomedich-811	22	3	is	be	AUX
biomedich-811	22	4	endemic	endemic	ADJ
biomedich-811	22	5	in	in	ADP
biomedich-811	22	6	85	85	NUM
biomedich-811	22	7	tropical	tropical	ADJ
biomedich-811	22	8	countries	country	NOUN
biomedich-811	22	9	worldwide	worldwide	ADV
biomedich-811	22	10	in	in	ADP
biomedich-811	22	11	2022	2022	NUM
biomedich-811	22	12	and	and	CCONJ
biomedich-811	22	13	has	have	VERB
biomedich-811	22	14	high	high	ADJ
biomedich-811	22	15	morbidity	morbidity	NOUN
biomedich-811	22	16	and	and	CCONJ
biomedich-811	22	17	mortality	mortality	NOUN
biomedich-811	22	18	.	.	PUNCT
biomedich-811	23	1	most	most	ADJ
biomedich-811	23	2	cases	case	NOUN
biomedich-811	23	3	were	be	AUX
biomedich-811	23	4	in	in	ADP
biomedich-811	23	5	african	african	ADJ
biomedich-811	23	6	countries	country	NOUN
biomedich-811	23	7	,	,	PUNCT
biomedich-811	23	8	but	but	CCONJ
biomedich-811	23	9	asia	asia	PROPN
biomedich-811	23	10	is	be	AUX
biomedich-811	23	11	in	in	ADP
biomedich-811	23	12	the	the	DET
biomedich-811	23	13	second	second	ADJ
biomedich-811	23	14	position	position	NOUN
biomedich-811	23	15	,	,	PUNCT
biomedich-811	23	16	with	with	ADP
biomedich-811	23	17	indonesia	indonesia	PROPN
biomedich-811	23	18	at	at	ADP
biomedich-811	23	19	the	the	DET
biomedich-811	23	20	second	second	ADJ
biomedich-811	23	21	rank	rank	NOUN
biomedich-811	23	22	for	for	ADP
biomedich-811	23	23	malaria	malaria	NOUN
biomedich-811	23	24	cases	case	NOUN
biomedich-811	23	25	prevalence	prevalence	NOUN
biomedich-811	23	26	in	in	ADP
biomedich-811	23	27	asia	asia	PROPN
biomedich-811	23	28	with	with	ADP
biomedich-811	23	29	443.530	443.530	NUM
biomedich-811	23	30	cases	case	NOUN
biomedich-811	23	31	in	in	ADP
biomedich-811	23	32	2022	2022	NUM
biomedich-811	23	33	(	(	PUNCT
biomedich-811	23	34	who	who	PRON
biomedich-811	23	35	,	,	PUNCT
biomedich-811	23	36	2023	2023	NUM
biomedich-811	23	37	)	)	PUNCT
biomedich-811	23	38	(	(	PUNCT
biomedich-811	23	39	kemenkes	kemenke	NOUN
biomedich-811	23	40	,	,	PUNCT
biomedich-811	23	41	2022	2022	NUM
biomedich-811	23	42	)	)	PUNCT
biomedich-811	23	43	.	.	PUNCT
biomedich-811	24	1	the	the	DET
biomedich-811	24	2	world	world	PROPN
biomedich-811	24	3	health	health	NOUN
biomedich-811	24	4	organisation	organisation	NOUN
biomedich-811	24	5	(	(	PUNCT
biomedich-811	24	6	who	who	PRON
biomedich-811	24	7	)	)	PUNCT
biomedich-811	24	8	has	have	VERB
biomedich-811	24	9	several	several	ADJ
biomedich-811	24	10	programs	program	NOUN
biomedich-811	24	11	to	to	PART
biomedich-811	24	12	control	control	VERB
biomedich-811	24	13	malaria	malaria	NOUN
biomedich-811	24	14	globally	globally	ADV
biomedich-811	24	15	.	.	PUNCT
biomedich-811	25	1	malaria	malaria	NOUN
biomedich-811	25	2	case	case	NOUN
biomedich-811	25	3	management	management	NOUN
biomedich-811	25	4	with	with	ADP
biomedich-811	25	5	pr	pr	NOUN
biomedich-811	25	6	ompt	ompt	ADJ
biomedich-811	25	7	access	access	NOUN
biomedich-811	25	8	to	to	ADP
biomedich-811	25	9	early	early	ADJ
biomedich-811	25	10	diagnostic	diagnostic	ADJ
biomedich-811	25	11	and	and	CCONJ
biomedich-811	25	12	effective	effective	ADJ
biomedich-811	25	13	antimalarial	antimalarial	ADJ
biomedich-811	25	14	therapies	therapy	NOUN
biomedich-811	25	15	is	be	AUX
biomedich-811	25	16	vital	vital	ADJ
biomedich-811	25	17	to	to	ADP
biomedich-811	25	18	reducing	reduce	VERB
biomedich-811	25	19	malaria	malaria	NOUN
biomedich-811	25	20	morbidity	morbidity	NOUN
biomedich-811	25	21	and	and	CCONJ
biomedich-811	25	22	mortality	mortality	NOUN
biomedich-811	25	23	(	(	PUNCT
biomedich-811	25	24	who	who	PRON
biomedich-811	25	25	,	,	PUNCT
biomedich-811	25	26	2022	2022	NUM
biomedich-811	25	27	)	)	PUNCT
biomedich-811	25	28	the	the	DET
biomedich-811	25	29	first	first	ADJ
biomedich-811	25	30	synthesized	synthesize	VERB
biomedich-811	25	31	drug	drug	NOUN
biomedich-811	25	32	to	to	PART
biomedich-811	25	33	treat	treat	VERB
biomedich-811	25	34	malaria	malaria	NOUN
biomedich-811	25	35	was	be	AUX
biomedich-811	25	36	chloroquine	chloroquine	NOUN
biomedich-811	25	37	(	(	PUNCT
biomedich-811	25	38	cq	cq	NOUN
biomedich-811	25	39	)	)	PUNCT
biomedich-811	25	40	.	.	PUNCT
biomedich-811	26	1	it	it	PRON
biomedich-811	26	2	was	be	AUX
biomedich-811	26	3	introduced	introduce	VERB
biomedich-811	26	4	in	in	ADP
biomedich-811	26	5	the	the	DET
biomedich-811	26	6	early	early	ADJ
biomedich-811	26	7	1940s	1940	NOUN
biomedich-811	26	8	,	,	PUNCT
biomedich-811	26	9	but	but	CCONJ
biomedich-811	26	10	the	the	DET
biomedich-811	26	11	plasmodium	plasmodium	NOUN
biomedich-811	26	12	resistance	resistance	NOUN
biomedich-811	26	13	emerged	emerge	VERB
biomedich-811	26	14	by	by	ADP
biomedich-811	26	15	the	the	DET
biomedich-811	26	16	early	early	ADJ
biomedich-811	26	17	1960s	1960	NOUN
biomedich-811	26	18	and	and	CCONJ
biomedich-811	26	19	spread	spread	VERB
biomedich-811	26	20	across	across	ADP
biomedich-811	26	21	different	different	ADJ
biomedich-811	26	22	geographical	geographical	ADJ
biomedich-811	26	23	regions	region	NOUN
biomedich-811	26	24	(	(	PUNCT
biomedich-811	26	25	manirakiza	manirakiza	NOUN
biomedich-811	26	26	et	et	PROPN
biomedich-811	26	27	al	al	PROPN
biomedich-811	26	28	.	.	PROPN
biomedich-811	26	29	,	,	PUNCT
biomedich-811	26	30	2022	2022	NUM
biomedich-811	26	31	)	)	PUNCT
biomedich-811	26	32	,	,	PUNCT
biomedich-811	26	33	including	include	VERB
biomedich-811	26	34	indonesia	indonesia	PROPN
biomedich-811	26	35	in	in	ADP
biomedich-811	26	36	1974	1974	NUM
biomedich-811	26	37	(	(	PUNCT
biomedich-811	26	38	fitri	fitri	PROPN
biomedich-811	26	39	et	et	PROPN
biomedich-811	26	40	al	al	PROPN
biomedich-811	26	41	.	.	PROPN
biomedich-811	26	42	,	,	PUNCT
biomedich-811	26	43	2023	2023	NUM
biomedich-811	26	44	)	)	PUNCT
biomedich-811	26	45	.	.	PUNCT
biomedich-811	27	1	after	after	ADP
biomedich-811	27	2	spreading	spread	VERB
biomedich-811	27	3	cq	cq	ADP
biomedich-811	27	4	resistance	resistance	NOUN
biomedich-811	27	5	throughout	throughout	ADP
biomedich-811	27	6	malaria	malaria	NOUN
biomedich-811	27	7	-	-	PUNCT
biomedich-811	27	8	endemic	endemic	ADJ
biomedich-811	27	9	countries	country	NOUN
biomedich-811	27	10	,	,	PUNCT
biomedich-811	27	11	who	who	PRON
biomedich-811	27	12	recommended	recommend	VERB
biomedich-811	27	13	the	the	DET
biomedich-811	27	14	use	use	NOUN
biomedich-811	27	15	of	of	ADP
biomedich-811	27	16	sulfadoxine	sulfadoxine	ADJ
biomedich-811	27	17	-	-	PUNCT
biomedich-811	27	18	pyrimethamine	pyrimethamine	NOUN
biomedich-811	27	19	(	(	PUNCT
biomedich-811	27	20	sp	sp	NOUN
biomedich-811	27	21	)	)	PUNCT
biomedich-811	27	22	.	.	PUNCT
biomedich-811	28	1	however	however	ADV
biomedich-811	28	2	,	,	PUNCT
biomedich-811	28	3	the	the	DET
biomedich-811	28	4	sp	sp	ADP
biomedich-811	28	5	resistance	resistance	NOUN
biomedich-811	28	6	develops	develop	VERB
biomedich-811	28	7	rapidly	rapidly	ADV
biomedich-811	28	8	,	,	PUNCT
biomedich-811	28	9	starting	start	VERB
biomedich-811	28	10	in	in	ADP
biomedich-811	28	11	southeast	southeast	PROPN
biomedich-811	28	12	asia	asia	PROPN
biomedich-811	28	13	within	within	ADP
biomedich-811	28	14	one	one	NUM
biomedich-811	28	15	year	year	NOUN
biomedich-811	28	16	of	of	ADP
biomedich-811	28	17	its	its	PRON
biomedich-811	28	18	use	use	NOUN
biomedich-811	28	19	(	(	PUNCT
biomedich-811	28	20	noreen	noreen	PROPN
biomedich-811	28	21	et	et	PROPN
biomedich-811	28	22	al	al	PROPN
biomedich-811	28	23	.	.	PROPN
biomedich-811	28	24	,	,	PUNCT
biomedich-811	28	25	2021	2021	NUM
biomedich-811	28	26	)	)	PUNCT
biomedich-811	28	27	.	.	PUNCT
biomedich-811	29	1	subsequently	subsequently	ADV
biomedich-811	29	2	,	,	PUNCT
biomedich-811	29	3	the	the	DET
biomedich-811	29	4	sp	sp	ADP
biomedich-811	29	5	resistance	resistance	NOUN
biomedich-811	29	6	emerged	emerge	VERB
biomedich-811	29	7	in	in	ADP
biomedich-811	29	8	africa	africa	PROPN
biomedich-811	29	9	and	and	CCONJ
biomedich-811	29	10	latin	latin	PROPN
biomedich-811	29	11	america	america	PROPN
biomedich-811	29	12	(	(	PUNCT
biomedich-811	29	13	nsanzabana	nsanzabana	PROPN
biomedich-811	29	14	et	et	PROPN
biomedich-811	29	15	al	al	PROPN
biomedich-811	29	16	.	.	PROPN
biomedich-811	29	17	,	,	PUNCT
biomedich-811	29	18	2018	2018	NUM
biomedich-811	29	19	)	)	PUNCT
biomedich-811	29	20	.	.	PUNCT
biomedich-811	30	1	following	follow	VERB
biomedich-811	30	2	the	the	DET
biomedich-811	30	3	sp	sp	NOUN
biomedich-811	30	4	resistance	resistance	NOUN
biomedich-811	30	5	,	,	PUNCT
biomedich-811	30	6	mefloquine	mefloquine	NOUN
biomedich-811	30	7	(	(	PUNCT
biomedich-811	30	8	mq	mq	NOUN
biomedich-811	30	9	)	)	PUNCT
biomedich-811	30	10	and	and	CCONJ
biomedich-811	30	11	amodiaquine	amodiaquine	PROPN
biomedich-811	30	12	(	(	PUNCT
biomedich-811	30	13	aq	aq	NOUN
biomedich-811	30	14	)	)	PUNCT
biomedich-811	30	15	were	be	AUX
biomedich-811	30	16	used	use	VERB
biomedich-811	30	17	to	to	PART
biomedich-811	30	18	treat	treat	VERB
biomedich-811	30	19	malaria	malaria	NOUN
biomedich-811	30	20	.	.	PUNCT
biomedich-811	31	1	the	the	DET
biomedich-811	31	2	resistance	resistance	NOUN
biomedich-811	31	3	develops	develop	VERB
biomedich-811	31	4	again	again	ADV
biomedich-811	31	5	five	five	NUM
biomedich-811	31	6	years	year	NOUN
biomedich-811	31	7	after	after	ADP
biomedich-811	31	8	the	the	DET
biomedich-811	31	9	use	use	NOUN
biomedich-811	31	10	(	(	PUNCT
biomedich-811	31	11	dondorp	dondorp	NOUN
biomedich-811	31	12	et	et	NOUN
biomedich-811	31	13	al	al	PROPN
biomedich-811	31	14	.	.	PROPN
biomedich-811	31	15	,	,	PUNCT
biomedich-811	31	16	2009	2009	NUM
biomedich-811	31	17	)	)	PUNCT
biomedich-811	31	18	.	.	PUNCT
biomedich-811	32	1	finally	finally	ADV
biomedich-811	32	2	,	,	PUNCT
biomedich-811	32	3	who	who	PRON
biomedich-811	32	4	recommended	recommend	VERB
biomedich-811	32	5	the	the	DET
biomedich-811	32	6	artemisinin	artemisinin	NOUN
biomedich-811	32	7	-	-	PUNCT
biomedich-811	32	8	based	base	VERB
biomedich-811	32	9	combination	combination	NOUN
biomedich-811	32	10	therapy	therapy	NOUN
biomedich-811	32	11	(	(	PUNCT
biomedich-811	32	12	act	act	PROPN
biomedich-811	32	13	)	)	PUNCT
biomedich-811	32	14	as	as	ADP
biomedich-811	32	15	the	the	DET
biomedich-811	32	16	first	first	ADJ
biomedich-811	32	17	-	-	PUNCT
biomedich-811	32	18	line	line	NOUN
biomedich-811	32	19	drug	drug	NOUN
biomedich-811	32	20	for	for	ADP
biomedich-811	32	21	plasmodium	plasmodium	NOUN
biomedich-811	32	22	falciparum	falciparum	ADJ
biomedich-811	32	23	malaria	malaria	NOUN
biomedich-811	32	24	in	in	ADP
biomedich-811	32	25	https://doi.org/10.14421/biomedich.2025.142.673-678	https://doi.org/10.14421/biomedich.2025.142.673-678	NUM
biomedich-811	32	26	674	674	NUM
biomedich-811	32	27	biology	biology	NOUN
biomedich-811	32	28	,	,	PUNCT
biomedich-811	32	29	medicine	medicine	NOUN
biomedich-811	32	30	,	,	PUNCT
biomedich-811	32	31	&	&	CCONJ
biomedich-811	32	32	natural	natural	ADJ
biomedich-811	32	33	product	product	NOUN
biomedich-811	32	34	chemistry	chemistry	NOUN
biomedich-811	32	35	14	14	NUM
biomedich-811	32	36	(	(	PUNCT
biomedich-811	32	37	2	2	NUM
biomedich-811	32	38	)	)	PUNCT
biomedich-811	32	39	,	,	PUNCT
biomedich-811	32	40	2025	2025	NUM
biomedich-811	32	41	:	:	PUNCT
biomedich-811	32	42	673	673	NUM
biomedich-811	32	43	-	-	SYM
biomedich-811	32	44	678	678	NUM
biomedich-811	32	45	countries	country	NOUN
biomedich-811	32	46	where	where	SCONJ
biomedich-811	32	47	chloroquine	chloroquine	NOUN
biomedich-811	32	48	,	,	PUNCT
biomedich-811	32	49	sulfadoxinepyrimethamine	sulfadoxinepyrimethamine	NOUN
biomedich-811	32	50	,	,	PUNCT
biomedich-811	32	51	and	and	CCONJ
biomedich-811	32	52	amodiaquine	amodiaquine	PROPN
biomedich-811	32	53	have	have	AUX
biomedich-811	32	54	been	be	AUX
biomedich-811	32	55	resistant	resistant	ADJ
biomedich-811	32	56	since	since	SCONJ
biomedich-811	32	57	2001	2001	NUM
biomedich-811	32	58	,	,	PUNCT
biomedich-811	32	59	and	and	CCONJ
biomedich-811	32	60	it	it	PRON
biomedich-811	32	61	has	have	AUX
biomedich-811	32	62	contributed	contribute	VERB
biomedich-811	32	63	significantly	significantly	ADV
biomedich-811	32	64	to	to	PART
biomedich-811	32	65	decrease	decrease	VERB
biomedich-811	32	66	the	the	DET
biomedich-811	32	67	morbidity	morbidity	NOUN
biomedich-811	32	68	and	and	CCONJ
biomedich-811	32	69	mortality	mortality	NOUN
biomedich-811	32	70	from	from	ADP
biomedich-811	32	71	251	251	NUM
biomedich-811	32	72	million	million	NUM
biomedich-811	32	73	cases	case	NOUN
biomedich-811	32	74	and	and	CCONJ
biomedich-811	32	75	585.000	585.000	NUM
biomedich-811	32	76	death	death	NOUN
biomedich-811	32	77	in	in	ADP
biomedich-811	32	78	2015	2015	NUM
biomedich-811	32	79	to	to	ADP
biomedich-811	32	80	229	229	NUM
biomedich-811	32	81	million	million	NUM
biomedich-811	32	82	cases	case	NOUN
biomedich-811	32	83	and	and	CCONJ
biomedich-811	32	84	409.000	409.000	NUM
biomedich-811	32	85	death	death	NOUN
biomedich-811	32	86	in	in	ADP
biomedich-811	32	87	2019	2019	NUM
biomedich-811	32	88	(	(	PUNCT
biomedich-811	32	89	who	who	PRON
biomedich-811	32	90	,	,	PUNCT
biomedich-811	32	91	2023	2023	NUM
biomedich-811	32	92	)	)	PUNCT
biomedich-811	32	93	.	.	PUNCT
biomedich-811	33	1	although	although	SCONJ
biomedich-811	33	2	there	there	PRON
biomedich-811	33	3	was	be	VERB
biomedich-811	33	4	a	a	DET
biomedich-811	33	5	decrease	decrease	NOUN
biomedich-811	33	6	in	in	ADP
biomedich-811	33	7	the	the	DET
biomedich-811	33	8	number	number	NOUN
biomedich-811	33	9	of	of	ADP
biomedich-811	33	10	malaria	malaria	NOUN
biomedich-811	33	11	-	-	PUNCT
biomedich-811	33	12	endemic	endemic	ADJ
biomedich-811	33	13	countries	country	NOUN
biomedich-811	33	14	,	,	PUNCT
biomedich-811	33	15	however	however	ADV
biomedich-811	33	16	,	,	PUNCT
biomedich-811	33	17	malaria	malaria	ADJ
biomedich-811	33	18	elimination	elimination	NOUN
biomedich-811	33	19	is	be	AUX
biomedich-811	33	20	challenging	challenge	VERB
biomedich-811	33	21	due	due	ADJ
biomedich-811	33	22	to	to	ADP
biomedich-811	33	23	some	some	DET
biomedich-811	33	24	issues	issue	NOUN
biomedich-811	33	25	.	.	PUNCT
biomedich-811	34	1	one	one	NUM
biomedich-811	34	2	of	of	ADP
biomedich-811	34	3	the	the	DET
biomedich-811	34	4	critical	critical	ADJ
biomedich-811	34	5	problems	problem	NOUN
biomedich-811	34	6	was	be	AUX
biomedich-811	34	7	the	the	DET
biomedich-811	34	8	antimalarial	antimalarial	ADJ
biomedich-811	34	9	resistance	resistance	NOUN
biomedich-811	34	10	.	.	PUNCT
biomedich-811	35	1	soon	soon	ADV
biomedich-811	35	2	after	after	ADP
biomedich-811	35	3	the	the	DET
biomedich-811	35	4	global	global	ADJ
biomedich-811	35	5	implementation	implementation	NOUN
biomedich-811	35	6	of	of	ADP
biomedich-811	35	7	act	act	NOUN
biomedich-811	35	8	,	,	PUNCT
biomedich-811	35	9	an	an	DET
biomedich-811	35	10	issue	issue	NOUN
biomedich-811	35	11	of	of	ADP
biomedich-811	35	12	artemisinin	artemisinin	PROPN
biomedich-811	35	13	resistance	resistance	NOUN
biomedich-811	35	14	in	in	ADP
biomedich-811	35	15	the	the	DET
biomedich-811	35	16	greater	great	ADJ
biomedich-811	35	17	mekong	mekong	NOUN
biomedich-811	35	18	subregion	subregion	NOUN
biomedich-811	35	19	is	be	AUX
biomedich-811	35	20	reported	report	VERB
biomedich-811	35	21	(	(	PUNCT
biomedich-811	35	22	dondorp	dondorp	NOUN
biomedich-811	35	23	et	et	PROPN
biomedich-811	35	24	al	al	PROPN
biomedich-811	35	25	.	.	PROPN
biomedich-811	35	26	,	,	PUNCT
biomedich-811	35	27	2009	2009	NUM
biomedich-811	35	28	)	)	PUNCT
biomedich-811	35	29	.	.	PUNCT
biomedich-811	36	1	antimalarial	antimalarial	ADJ
biomedich-811	36	2	drug	drug	NOUN
biomedich-811	36	3	resistance	resistance	NOUN
biomedich-811	36	4	is	be	AUX
biomedich-811	36	5	the	the	DET
biomedich-811	36	6	ability	ability	NOUN
biomedich-811	36	7	of	of	ADP
biomedich-811	36	8	the	the	DET
biomedich-811	36	9	plasmodium	plasmodium	NOUN
biomedich-811	36	10	to	to	PART
biomedich-811	36	11	survive	survive	VERB
biomedich-811	36	12	and/or	and/or	CCONJ
biomedich-811	36	13	multiply	multiply	VERB
biomedich-811	36	14	despite	despite	SCONJ
biomedich-811	36	15	the	the	DET
biomedich-811	36	16	drug	drug	NOUN
biomedich-811	36	17	's	's	PART
biomedich-811	36	18	administration	administration	NOUN
biomedich-811	36	19	and	and	CCONJ
biomedich-811	36	20	absorption	absorption	NOUN
biomedich-811	36	21	in	in	ADP
biomedich-811	36	22	equal	equal	ADJ
biomedich-811	36	23	doses	dose	NOUN
biomedich-811	36	24	or	or	CCONJ
biomedich-811	36	25	higher	high	ADJ
biomedich-811	36	26	than	than	ADP
biomedich-811	36	27	the	the	DET
biomedich-811	36	28	recommended	recommend	VERB
biomedich-811	36	29	,	,	PUNCT
biomedich-811	36	30	but	but	CCONJ
biomedich-811	36	31	within	within	ADP
biomedich-811	36	32	a	a	DET
biomedich-811	36	33	tolerance	tolerance	NOUN
biomedich-811	36	34	of	of	ADP
biomedich-811	36	35	the	the	DET
biomedich-811	36	36	human	human	NOUN
biomedich-811	36	37	(	(	PUNCT
biomedich-811	36	38	fairhurst	fairhurst	ADJ
biomedich-811	36	39	,	,	PUNCT
biomedich-811	36	40	2015	2015	NUM
biomedich-811	36	41	)	)	PUNCT
biomedich-811	36	42	.	.	PUNCT
biomedich-811	37	1	based	base	VERB
biomedich-811	37	2	on	on	ADP
biomedich-811	37	3	the	the	DET
biomedich-811	37	4	antimalarial	antimalarial	ADJ
biomedich-811	37	5	drug	drug	NOUN
biomedich-811	37	6	class	class	NOUN
biomedich-811	37	7	,	,	PUNCT
biomedich-811	37	8	resistance	resistance	NOUN
biomedich-811	37	9	mechanisms	mechanism	NOUN
biomedich-811	37	10	occur	occur	VERB
biomedich-811	37	11	in	in	ADP
biomedich-811	37	12	several	several	ADJ
biomedich-811	37	13	ways	way	NOUN
biomedich-811	37	14	,	,	PUNCT
biomedich-811	37	15	including	include	VERB
biomedich-811	37	16	causing	cause	VERB
biomedich-811	37	17	oxidative	oxidative	ADJ
biomedich-811	37	18	stress	stress	NOUN
biomedich-811	37	19	,	,	PUNCT
biomedich-811	37	20	affecting	affect	VERB
biomedich-811	37	21	heme	heme	NOUN
biomedich-811	37	22	detoxification	detoxification	NOUN
biomedich-811	37	23	,	,	PUNCT
biomedich-811	37	24	inhibiting	inhibit	VERB
biomedich-811	37	25	protein	protein	NOUN
biomedich-811	37	26	synthesis	synthesis	NOUN
biomedich-811	37	27	,	,	PUNCT
biomedich-811	37	28	inhibiting	inhibit	VERB
biomedich-811	37	29	folate	folate	NOUN
biomedich-811	37	30	synthesis	synthesis	NOUN
biomedich-811	37	31	,	,	PUNCT
biomedich-811	37	32	interfering	interfere	VERB
biomedich-811	37	33	hemozoin	hemozoin	NOUN
biomedich-811	37	34	formation	formation	NOUN
biomedich-811	37	35	,	,	PUNCT
biomedich-811	37	36	and	and	CCONJ
biomedich-811	37	37	inhibiting	inhibit	VERB
biomedich-811	37	38	mitochondrial	mitochondrial	ADJ
biomedich-811	37	39	electron	electron	NOUN
biomedich-811	37	40	transport	transport	NOUN
biomedich-811	37	41	(	(	PUNCT
biomedich-811	37	42	si	si	X
biomedich-811	37	43	et	et	PROPN
biomedich-811	37	44	al	al	PROPN
biomedich-811	37	45	.	.	PROPN
biomedich-811	37	46	,	,	PUNCT
biomedich-811	37	47	2023)(fitri	2023)(fitri	NUM
biomedich-811	37	48	et	et	PROPN
biomedich-811	37	49	al	al	PROPN
biomedich-811	37	50	.	.	PROPN
biomedich-811	37	51	,	,	PUNCT
biomedich-811	37	52	2023	2023	NUM
biomedich-811	37	53	)	)	PUNCT
biomedich-811	37	54	.	.	PUNCT
biomedich-811	38	1	detection	detection	NOUN
biomedich-811	38	2	of	of	ADP
biomedich-811	38	3	antimalarial	antimalarial	ADJ
biomedich-811	38	4	drug	drug	NOUN
biomedich-811	38	5	resistance	resistance	NOUN
biomedich-811	38	6	can	can	AUX
biomedich-811	38	7	be	be	AUX
biomedich-811	38	8	performed	perform	VERB
biomedich-811	38	9	by	by	ADP
biomedich-811	38	10	any	any	PRON
biomedich-811	38	11	of	of	ADP
biomedich-811	38	12	three	three	NUM
biomedich-811	38	13	approaches	approach	NOUN
biomedich-811	38	14	,	,	PUNCT
biomedich-811	38	15	including	include	VERB
biomedich-811	38	16	in	in	ADP
biomedich-811	38	17	vivo	vivo	ADJ
biomedich-811	38	18	studies	study	NOUN
biomedich-811	38	19	to	to	PART
biomedich-811	38	20	assess	assess	VERB
biomedich-811	38	21	the	the	DET
biomedich-811	38	22	efficacy	efficacy	NOUN
biomedich-811	38	23	of	of	ADP
biomedich-811	38	24	drugs	drug	NOUN
biomedich-811	38	25	in	in	ADP
biomedich-811	38	26	patients	patient	NOUN
biomedich-811	38	27	,	,	PUNCT
biomedich-811	38	28	in	in	ADP
biomedich-811	38	29	vitro/	vitro/	NUM
biomedich-811	38	30	ex	ex	NOUN
biomedich-811	38	31	vivo	vivo	ADJ
biomedich-811	38	32	studies	study	NOUN
biomedich-811	38	33	to	to	PART
biomedich-811	38	34	evaluate	evaluate	VERB
biomedich-811	38	35	parasite	parasite	ADJ
biomedich-811	38	36	susceptibility	susceptibility	NOUN
biomedich-811	38	37	to	to	ADP
biomedich-811	38	38	the	the	DET
biomedich-811	38	39	drugs	drug	NOUN
biomedich-811	38	40	,	,	PUNCT
biomedich-811	38	41	and/or	and/or	CCONJ
biomedich-811	38	42	molecular	molecular	ADJ
biomedich-811	38	43	identification	identification	NOUN
biomedich-811	38	44	to	to	PART
biomedich-811	38	45	detect	detect	VERB
biomedich-811	38	46	validated	validated	ADJ
biomedich-811	38	47	gene	gene	NOUN
biomedich-811	38	48	mutations	mutation	NOUN
biomedich-811	38	49	and/or	and/or	CCONJ
biomedich-811	38	50	gene	gene	NOUN
biomedich-811	38	51	copy	copy	NOUN
biomedich-811	38	52	number	number	NOUN
biomedich-811	38	53	changes	change	NOUN
biomedich-811	38	54	that	that	PRON
biomedich-811	38	55	are	be	AUX
biomedich-811	38	56	associated	associate	VERB
biomedich-811	38	57	with	with	ADP
biomedich-811	38	58	the	the	DET
biomedich-811	38	59	drug	drug	NOUN
biomedich-811	38	60	resistance	resistance	NOUN
biomedich-811	38	61	(	(	PUNCT
biomedich-811	38	62	nsanzabana	nsanzabana	NOUN
biomedich-811	38	63	et	et	PROPN
biomedich-811	38	64	al	al	PROPN
biomedich-811	38	65	.	.	PROPN
biomedich-811	38	66	,	,	PUNCT
biomedich-811	38	67	2018)(who	2018)(who	NUM
biomedich-811	38	68	,	,	PUNCT
biomedich-811	38	69	2022	2022	NUM
biomedich-811	38	70	)	)	PUNCT
biomedich-811	38	71	.	.	PUNCT
biomedich-811	39	1	in	in	ADP
biomedich-811	39	2	vivo	vivo	NOUN
biomedich-811	39	3	test	test	NOUN
biomedich-811	39	4	is	be	AUX
biomedich-811	39	5	the	the	DET
biomedich-811	39	6	first	first	ADJ
biomedich-811	39	7	method	method	NOUN
biomedich-811	39	8	described	describe	VERB
biomedich-811	39	9	by	by	ADP
biomedich-811	39	10	who	who	PRON
biomedich-811	39	11	protocol	protocol	VERB
biomedich-811	39	12	;	;	PUNCT
biomedich-811	39	13	it	it	PRON
biomedich-811	39	14	is	be	AUX
biomedich-811	39	15	known	know	VERB
biomedich-811	39	16	as	as	ADP
biomedich-811	39	17	therapeutic	therapeutic	ADJ
biomedich-811	39	18	efficacy	efficacy	NOUN
biomedich-811	39	19	studies	study	NOUN
biomedich-811	39	20	(	(	PUNCT
biomedich-811	39	21	tes	tes	NOUN
biomedich-811	39	22	)	)	PUNCT
biomedich-811	39	23	.	.	PUNCT
biomedich-811	40	1	the	the	DET
biomedich-811	40	2	method	method	NOUN
biomedich-811	40	3	evaluates	evaluate	VERB
biomedich-811	40	4	the	the	DET
biomedich-811	40	5	efficacy	efficacy	NOUN
biomedich-811	40	6	of	of	ADP
biomedich-811	40	7	the	the	DET
biomedich-811	40	8	antimalarial	antimalarial	ADJ
biomedich-811	40	9	drug	drug	NOUN
biomedich-811	40	10	clinically	clinically	ADV
biomedich-811	40	11	.	.	PUNCT
biomedich-811	41	1	the	the	DET
biomedich-811	41	2	efficacy	efficacy	NOUN
biomedich-811	41	3	test	test	NOUN
biomedich-811	41	4	can	can	AUX
biomedich-811	41	5	also	also	ADV
biomedich-811	41	6	be	be	AUX
biomedich-811	41	7	performed	perform	VERB
biomedich-811	41	8	by	by	ADP
biomedich-811	41	9	measuring	measure	VERB
biomedich-811	41	10	the	the	DET
biomedich-811	41	11	level	level	NOUN
biomedich-811	41	12	of	of	ADP
biomedich-811	41	13	antimalarial	antimalarial	ADJ
biomedich-811	41	14	drug	drug	NOUN
biomedich-811	41	15	collected	collect	VERB
biomedich-811	41	16	from	from	ADP
biomedich-811	41	17	the	the	DET
biomedich-811	41	18	blood	blood	NOUN
biomedich-811	41	19	of	of	ADP
biomedich-811	41	20	malaria	malaria	NOUN
biomedich-811	41	21	patients	patient	NOUN
biomedich-811	41	22	using	use	VERB
biomedich-811	41	23	the	the	DET
biomedich-811	41	24	high	high	ADJ
biomedich-811	41	25	-	-	PUNCT
biomedich-811	41	26	performance	performance	NOUN
biomedich-811	41	27	liquid	liquid	ADJ
biomedich-811	41	28	chromatography	chromatography	NOUN
biomedich-811	41	29	(	(	PUNCT
biomedich-811	41	30	hplc	hplc	NOUN
biomedich-811	41	31	)	)	PUNCT
biomedich-811	41	32	method	method	NOUN
biomedich-811	41	33	.	.	PUNCT
biomedich-811	42	1	the	the	DET
biomedich-811	42	2	drug	drug	NOUN
biomedich-811	42	3	level	level	NOUN
biomedich-811	42	4	analysis	analysis	NOUN
biomedich-811	42	5	from	from	ADP
biomedich-811	42	6	blood	blood	NOUN
biomedich-811	42	7	can	can	AUX
biomedich-811	42	8	differentiate	differentiate	VERB
biomedich-811	42	9	medication	medication	NOUN
biomedich-811	42	10	nonadherence	nonadherence	NOUN
biomedich-811	42	11	and	and	CCONJ
biomedich-811	42	12	drug	drug	NOUN
biomedich-811	42	13	resistance	resistance	NOUN
biomedich-811	42	14	(	(	PUNCT
biomedich-811	42	15	who	who	PRON
biomedich-811	42	16	,	,	PUNCT
biomedich-811	42	17	2022	2022	NUM
biomedich-811	42	18	)	)	PUNCT
biomedich-811	42	19	.	.	PUNCT
biomedich-811	43	1	the	the	DET
biomedich-811	43	2	second	second	ADJ
biomedich-811	43	3	method	method	NOUN
biomedich-811	43	4	is	be	AUX
biomedich-811	43	5	an	an	DET
biomedich-811	43	6	in	in	ADP
biomedich-811	43	7	vitro	vitro	X
biomedich-811	43	8	or	or	CCONJ
biomedich-811	43	9	ex	ex	PRON
biomedich-811	43	10	vivo	vivo	ADJ
biomedich-811	43	11	test	test	NOUN
biomedich-811	43	12	,	,	PUNCT
biomedich-811	43	13	which	which	PRON
biomedich-811	43	14	observes	observe	VERB
biomedich-811	43	15	the	the	DET
biomedich-811	43	16	efficacy	efficacy	NOUN
biomedich-811	43	17	of	of	ADP
biomedich-811	43	18	an	an	DET
biomedich-811	43	19	antimalarial	antimalarial	ADJ
biomedich-811	43	20	drug	drug	NOUN
biomedich-811	43	21	on	on	ADP
biomedich-811	43	22	the	the	DET
biomedich-811	43	23	plasmodium	plasmodium	NOUN
biomedich-811	43	24	itself	itself	PRON
biomedich-811	43	25	.	.	PUNCT
biomedich-811	44	1	the	the	DET
biomedich-811	44	2	method	method	NOUN
biomedich-811	44	3	uses	use	VERB
biomedich-811	44	4	plasmodium	plasmodium	NOUN
biomedich-811	44	5	parasites	parasite	NOUN
biomedich-811	44	6	obtained	obtain	VERB
biomedich-811	44	7	from	from	ADP
biomedich-811	44	8	malaria	malaria	NOUN
biomedich-811	44	9	patients	patient	NOUN
biomedich-811	44	10	,	,	PUNCT
biomedich-811	44	11	which	which	PRON
biomedich-811	44	12	are	be	AUX
biomedich-811	44	13	cultured	cultured	ADJ
biomedich-811	44	14	and	and	CCONJ
biomedich-811	44	15	treated	treat	VERB
biomedich-811	44	16	with	with	ADP
biomedich-811	44	17	different	different	ADJ
biomedich-811	44	18	antimalarial	antimalarial	ADJ
biomedich-811	44	19	drugs	drug	NOUN
biomedich-811	44	20	with	with	ADP
biomedich-811	44	21	various	various	ADJ
biomedich-811	44	22	concentrations	concentration	NOUN
biomedich-811	44	23	,	,	PUNCT
biomedich-811	44	24	and	and	CCONJ
biomedich-811	44	25	the	the	DET
biomedich-811	44	26	plasmodium	plasmodium	NOUN
biomedich-811	44	27	growth	growth	NOUN
biomedich-811	44	28	and	and	CCONJ
biomedich-811	44	29	survival	survival	NOUN
biomedich-811	44	30	are	be	AUX
biomedich-811	44	31	evaluated	evaluate	VERB
biomedich-811	44	32	to	to	PART
biomedich-811	44	33	determine	determine	VERB
biomedich-811	44	34	the	the	DET
biomedich-811	44	35	drug	drug	NOUN
biomedich-811	44	36	susceptibility	susceptibility	NOUN
biomedich-811	44	37	and	and	CCONJ
biomedich-811	44	38	resistance	resistance	NOUN
biomedich-811	44	39	profile	profile	NOUN
biomedich-811	44	40	.	.	PUNCT
biomedich-811	45	1	the	the	DET
biomedich-811	45	2	last	last	ADJ
biomedich-811	45	3	method	method	NOUN
biomedich-811	45	4	is	be	AUX
biomedich-811	45	5	molecular	molecular	ADJ
biomedich-811	45	6	characterization	characterization	NOUN
biomedich-811	45	7	,	,	PUNCT
biomedich-811	45	8	which	which	PRON
biomedich-811	45	9	identifies	identify	VERB
biomedich-811	45	10	antimalarial	antimalarial	ADJ
biomedich-811	45	11	drug	drug	NOUN
biomedich-811	45	12	resistance	resistance	NOUN
biomedich-811	45	13	markers	marker	NOUN
biomedich-811	45	14	.	.	PUNCT
biomedich-811	46	1	the	the	DET
biomedich-811	46	2	common	common	ADJ
biomedich-811	46	3	associated	associate	VERB
biomedich-811	46	4	with	with	ADP
biomedich-811	46	5	antimalarial	antimalarial	ADJ
biomedich-811	46	6	resistance	resistance	NOUN
biomedich-811	46	7	markers	marker	NOUN
biomedich-811	46	8	are	be	AUX
biomedich-811	46	9	single	single	ADJ
biomedich-811	46	10	nucleotide	nucleotide	ADJ
biomedich-811	46	11	polymorphisms	polymorphism	NOUN
biomedich-811	46	12	(	(	PUNCT
biomedich-811	46	13	snps	snps	PROPN
biomedich-811	46	14	)	)	PUNCT
biomedich-811	46	15	or	or	CCONJ
biomedich-811	46	16	amplifications	amplification	NOUN
biomedich-811	46	17	of	of	ADP
biomedich-811	46	18	the	the	DET
biomedich-811	46	19	gene	gene	NOUN
biomedich-811	46	20	encoding	encoding	NOUN
biomedich-811	46	21	for	for	ADP
biomedich-811	46	22	drug	drug	NOUN
biomedich-811	46	23	target	target	NOUN
biomedich-811	46	24	proteins	protein	NOUN
biomedich-811	46	25	or	or	CCONJ
biomedich-811	46	26	copy	copy	NOUN
biomedich-811	46	27	-	-	PUNCT
biomedich-811	46	28	number	number	NOUN
biomedich-811	46	29	variations	variation	NOUN
biomedich-811	46	30	(	(	PUNCT
biomedich-811	46	31	cnvs	cnvs	NOUN
biomedich-811	46	32	)	)	PUNCT
biomedich-811	46	33	of	of	ADP
biomedich-811	46	34	transporters	transporter	NOUN
biomedich-811	46	35	.	.	PUNCT
biomedich-811	47	1	various	various	ADJ
biomedich-811	47	2	markers	marker	NOUN
biomedich-811	47	3	have	have	AUX
biomedich-811	47	4	been	be	AUX
biomedich-811	47	5	developed	develop	VERB
biomedich-811	47	6	for	for	ADP
biomedich-811	47	7	the	the	DET
biomedich-811	47	8	assessment	assessment	NOUN
biomedich-811	47	9	of	of	ADP
biomedich-811	47	10	the	the	DET
biomedich-811	47	11	known	know	VERB
biomedich-811	47	12	resistance	resistance	NOUN
biomedich-811	47	13	markers	marker	NOUN
biomedich-811	47	14	;	;	PUNCT
biomedich-811	47	15	for	for	ADP
biomedich-811	47	16	example	example	NOUN
biomedich-811	47	17	,	,	PUNCT
biomedich-811	47	18	chloroquine	chloroquine	NOUN
biomedich-811	47	19	-	-	PUNCT
biomedich-811	47	20	resistance	resistance	NOUN
biomedich-811	47	21	is	be	AUX
biomedich-811	47	22	associated	associate	VERB
biomedich-811	47	23	with	with	ADP
biomedich-811	47	24	the	the	DET
biomedich-811	47	25	p.	p.	NOUN
biomedich-811	47	26	falciparum	falciparum	ADJ
biomedich-811	47	27	chloroquine	chloroquine	NOUN
biomedich-811	47	28	-	-	PUNCT
biomedich-811	47	29	resistance	resistance	NOUN
biomedich-811	47	30	transporter	transporter	NOUN
biomedich-811	47	31	(	(	PUNCT
biomedich-811	47	32	pfcrt	pfcrt	ADJ
biomedich-811	47	33	)	)	PUNCT
biomedich-811	47	34	(	(	PUNCT
biomedich-811	47	35	manirakiza	manirakiza	NOUN
biomedich-811	47	36	et	et	PROPN
biomedich-811	47	37	al	al	PROPN
biomedich-811	47	38	.	.	PROPN
biomedich-811	47	39	,	,	PUNCT
biomedich-811	47	40	2022	2022	NUM
biomedich-811	47	41	)	)	PUNCT
biomedich-811	47	42	and	and	CCONJ
biomedich-811	47	43	p.	p.	NOUN
biomedich-811	47	44	falciparum	falciparum	ADJ
biomedich-811	47	45	multidrug	multidrug	NOUN
biomedich-811	47	46	resistance	resistance	NOUN
biomedich-811	47	47	gene	gene	NOUN
biomedich-811	47	48	1	1	NUM
biomedich-811	47	49	(	(	PUNCT
biomedich-811	47	50	pfmdr1	pfmdr1	PROPN
biomedich-811	47	51	)	)	PUNCT
biomedich-811	47	52	(	(	PUNCT
biomedich-811	47	53	al	al	PROPN
biomedich-811	47	54	-	-	PUNCT
biomedich-811	47	55	mekhlafi	mekhlafi	PROPN
biomedich-811	47	56	et	et	PROPN
biomedich-811	47	57	al	al	PROPN
biomedich-811	47	58	.	.	PROPN
biomedich-811	47	59	,	,	PUNCT
biomedich-811	47	60	2022	2022	NUM
biomedich-811	47	61	)	)	PUNCT
biomedich-811	47	62	.	.	PUNCT
biomedich-811	48	1	the	the	DET
biomedich-811	48	2	method	method	NOUN
biomedich-811	48	3	can	can	AUX
biomedich-811	48	4	be	be	AUX
biomedich-811	48	5	performed	perform	VERB
biomedich-811	48	6	by	by	ADP
biomedich-811	48	7	polymerase	polymerase	NOUN
biomedich-811	48	8	chain	chain	NOUN
biomedich-811	48	9	reaction	reaction	NOUN
biomedich-811	48	10	(	(	PUNCT
biomedich-811	48	11	pcr	pcr	NOUN
biomedich-811	48	12	)	)	PUNCT
biomedich-811	48	13	and	and	CCONJ
biomedich-811	48	14	sequencing	sequencing	NOUN
biomedich-811	48	15	.	.	PUNCT
biomedich-811	49	1	the	the	DET
biomedich-811	49	2	method	method	NOUN
biomedich-811	49	3	has	have	AUX
biomedich-811	49	4	progressively	progressively	ADV
biomedich-811	49	5	developed	develop	VERB
biomedich-811	49	6	in	in	ADP
biomedich-811	49	7	recent	recent	ADJ
biomedich-811	49	8	years	year	NOUN
biomedich-811	49	9	because	because	SCONJ
biomedich-811	49	10	it	it	PRON
biomedich-811	49	11	is	be	AUX
biomedich-811	49	12	more	more	ADV
biomedich-811	49	13	effective	effective	ADJ
biomedich-811	49	14	and	and	CCONJ
biomedich-811	49	15	has	have	VERB
biomedich-811	49	16	many	many	ADJ
biomedich-811	49	17	advantages	advantage	NOUN
biomedich-811	49	18	.	.	PUNCT
biomedich-811	50	1	validated	validate	VERB
biomedich-811	50	2	molecular	molecular	ADJ
biomedich-811	50	3	markers	marker	NOUN
biomedich-811	50	4	are	be	AUX
biomedich-811	50	5	highly	highly	ADV
biomedich-811	50	6	relevant	relevant	ADJ
biomedich-811	50	7	to	to	ADP
biomedich-811	50	8	detecting	detect	VERB
biomedich-811	50	9	and	and	CCONJ
biomedich-811	50	10	monitoring	monitor	VERB
biomedich-811	50	11	the	the	DET
biomedich-811	50	12	geospatial	geospatial	ADJ
biomedich-811	50	13	distribution	distribution	NOUN
biomedich-811	50	14	of	of	ADP
biomedich-811	50	15	resistant	resistant	ADJ
biomedich-811	50	16	parasites	parasite	NOUN
biomedich-811	50	17	,	,	PUNCT
biomedich-811	50	18	and	and	CCONJ
biomedich-811	50	19	their	their	PRON
biomedich-811	50	20	prevalence	prevalence	NOUN
biomedich-811	50	21	in	in	ADP
biomedich-811	50	22	parasite	parasite	ADJ
biomedich-811	50	23	populations	population	NOUN
biomedich-811	50	24	is	be	AUX
biomedich-811	50	25	often	often	ADV
biomedich-811	50	26	a	a	DET
biomedich-811	50	27	good	good	ADJ
biomedich-811	50	28	indicator	indicator	NOUN
biomedich-811	50	29	of	of	ADP
biomedich-811	50	30	clinical	clinical	ADJ
biomedich-811	50	31	resistance	resistance	NOUN
biomedich-811	50	32	(	(	PUNCT
biomedich-811	50	33	nsanzabana	nsanzabana	NOUN
biomedich-811	50	34	et	et	PROPN
biomedich-811	50	35	al	al	PROPN
biomedich-811	50	36	.	.	PROPN
biomedich-811	50	37	,	,	PUNCT
biomedich-811	50	38	2018	2018	NUM
biomedich-811	50	39	)	)	PUNCT
biomedich-811	50	40	.	.	PUNCT
biomedich-811	51	1	the	the	DET
biomedich-811	51	2	application	application	NOUN
biomedich-811	51	3	of	of	ADP
biomedich-811	51	4	antimalarial	antimalarial	ADJ
biomedich-811	51	5	drug	drug	NOUN
biomedich-811	51	6	resistance	resistance	NOUN
biomedich-811	51	7	detection	detection	NOUN
biomedich-811	51	8	depends	depend	VERB
biomedich-811	51	9	on	on	ADP
biomedich-811	51	10	the	the	DET
biomedich-811	51	11	facilities	facility	NOUN
biomedich-811	51	12	in	in	ADP
biomedich-811	51	13	malaria	malaria	NOUN
biomedich-811	51	14	-	-	PUNCT
biomedich-811	51	15	endemic	endemic	ADJ
biomedich-811	51	16	countries	country	NOUN
biomedich-811	51	17	or	or	CCONJ
biomedich-811	51	18	areas	area	NOUN
biomedich-811	51	19	.	.	PUNCT
biomedich-811	52	1	indonesia	indonesia	PROPN
biomedich-811	52	2	has	have	VERB
biomedich-811	52	3	no	no	DET
biomedich-811	52	4	specific	specific	ADJ
biomedich-811	52	5	regulation	regulation	NOUN
biomedich-811	52	6	regarding	regard	VERB
biomedich-811	52	7	the	the	DET
biomedich-811	52	8	standard	standard	ADJ
biomedich-811	52	9	procedure	procedure	NOUN
biomedich-811	52	10	or	or	CCONJ
biomedich-811	52	11	guideline	guideline	NOUN
biomedich-811	52	12	to	to	PART
biomedich-811	52	13	detect	detect	VERB
biomedich-811	52	14	antimalarial	antimalarial	ADJ
biomedich-811	52	15	resistance	resistance	NOUN
biomedich-811	52	16	(	(	PUNCT
biomedich-811	52	17	fitri	fitri	PROPN
biomedich-811	52	18	et	et	PROPN
biomedich-811	52	19	al	al	PROPN
biomedich-811	52	20	.	.	PROPN
biomedich-811	52	21	,	,	PUNCT
biomedich-811	52	22	2023	2023	NUM
biomedich-811	52	23	)	)	PUNCT
biomedich-811	52	24	.	.	PUNCT
biomedich-811	53	1	however	however	ADV
biomedich-811	53	2	,	,	PUNCT
biomedich-811	53	3	the	the	DET
biomedich-811	53	4	common	common	ADJ
biomedich-811	53	5	methods	method	NOUN
biomedich-811	53	6	used	use	VERB
biomedich-811	53	7	are	be	AUX
biomedich-811	53	8	tes	tes	NOUN
biomedich-811	53	9	and	and	CCONJ
biomedich-811	53	10	molecular	molecular	ADJ
biomedich-811	53	11	characterization	characterization	NOUN
biomedich-811	53	12	.	.	PUNCT
biomedich-811	54	1	a	a	DET
biomedich-811	54	2	molecular	molecular	ADJ
biomedich-811	54	3	characterization	characterization	NOUN
biomedich-811	54	4	method	method	NOUN
biomedich-811	54	5	needs	need	VERB
biomedich-811	54	6	good	good	ADJ
biomedich-811	54	7	infrastructure	infrastructure	NOUN
biomedich-811	54	8	and	and	CCONJ
biomedich-811	54	9	highly	highly	ADV
biomedich-811	54	10	trained	train	VERB
biomedich-811	54	11	staff	staff	NOUN
biomedich-811	54	12	.	.	PUNCT
biomedich-811	55	1	a	a	DET
biomedich-811	55	2	standard	standard	ADJ
biomedich-811	55	3	operating	operate	VERB
biomedich-811	55	4	procedure	procedure	NOUN
biomedich-811	55	5	for	for	ADP
biomedich-811	55	6	an	an	DET
biomedich-811	55	7	individual	individual	ADJ
biomedich-811	55	8	laboratory	laboratory	NOUN
biomedich-811	55	9	is	be	AUX
biomedich-811	55	10	required	require	VERB
biomedich-811	55	11	to	to	PART
biomedich-811	55	12	minimize	minimize	VERB
biomedich-811	55	13	unexpected	unexpected	ADJ
biomedich-811	55	14	results	result	NOUN
biomedich-811	55	15	.	.	PUNCT
biomedich-811	56	1	therefore	therefore	ADV
biomedich-811	56	2	,	,	PUNCT
biomedich-811	56	3	this	this	DET
biomedich-811	56	4	study	study	NOUN
biomedich-811	56	5	analyzed	analyze	VERB
biomedich-811	56	6	the	the	DET
biomedich-811	56	7	optimization	optimization	NOUN
biomedich-811	56	8	of	of	ADP
biomedich-811	56	9	the	the	DET
biomedich-811	56	10	molecular	molecular	ADJ
biomedich-811	56	11	characterization	characterization	NOUN
biomedich-811	56	12	method	method	NOUN
biomedich-811	56	13	to	to	PART
biomedich-811	56	14	identify	identify	VERB
biomedich-811	56	15	the	the	DET
biomedich-811	56	16	pfmdr1	pfmdr1	NOUN
biomedich-811	56	17	gene	gene	NOUN
biomedich-811	56	18	as	as	ADP
biomedich-811	56	19	an	an	DET
biomedich-811	56	20	antimalarial	antimalarial	ADJ
biomedich-811	56	21	resistance	resistance	NOUN
biomedich-811	56	22	predictor	predictor	NOUN
biomedich-811	56	23	.	.	PUNCT
biomedich-811	57	1	materials	material	NOUN
biomedich-811	57	2	and	and	CCONJ
biomedich-811	57	3	methods	method	NOUN
biomedich-811	57	4	research	research	NOUN
biomedich-811	57	5	design	design	NOUN
biomedich-811	57	6	and	and	CCONJ
biomedich-811	57	7	study	study	NOUN
biomedich-811	57	8	area	area	NOUN
biomedich-811	57	9	the	the	DET
biomedich-811	57	10	study	study	NOUN
biomedich-811	57	11	was	be	AUX
biomedich-811	57	12	exploratory	exploratory	ADJ
biomedich-811	57	13	research	research	NOUN
biomedich-811	57	14	conducted	conduct	VERB
biomedich-811	57	15	in	in	ADP
biomedich-811	57	16	marchdecember	marchdecember	NOUN
biomedich-811	57	17	2024	2024	NUM
biomedich-811	57	18	with	with	ADP
biomedich-811	57	19	a	a	DET
biomedich-811	57	20	consecutive	consecutive	ADJ
biomedich-811	57	21	sampling	sampling	NOUN
biomedich-811	57	22	method	method	NOUN
biomedich-811	57	23	.	.	PUNCT
biomedich-811	58	1	two	two	NUM
biomedich-811	58	2	types	type	NOUN
biomedich-811	58	3	of	of	ADP
biomedich-811	58	4	samples	sample	NOUN
biomedich-811	58	5	were	be	AUX
biomedich-811	58	6	included	include	VERB
biomedich-811	58	7	in	in	ADP
biomedich-811	58	8	this	this	DET
biomedich-811	58	9	study	study	NOUN
biomedich-811	58	10	;	;	PUNCT
biomedich-811	58	11	the	the	DET
biomedich-811	58	12	first	first	ADJ
biomedich-811	58	13	was	be	AUX
biomedich-811	58	14	malaria	malaria	ADJ
biomedich-811	58	15	patients	patient	NOUN
biomedich-811	58	16	admitted	admit	VERB
biomedich-811	58	17	at	at	ADP
biomedich-811	58	18	the	the	DET
biomedich-811	58	19	dr	dr	PROPN
biomedich-811	58	20	.	.	PROPN
biomedich-811	58	21	soebandi	soebandi	PROPN
biomedich-811	58	22	hospital	hospital	PROPN
biomedich-811	58	23	,	,	PUNCT
biomedich-811	58	24	jember	jember	PROPN
biomedich-811	58	25	,	,	PUNCT
biomedich-811	58	26	east	east	PROPN
biomedich-811	58	27	java	java	PROPN
biomedich-811	58	28	province	province	PROPN
biomedich-811	58	29	,	,	PUNCT
biomedich-811	58	30	who	who	PRON
biomedich-811	58	31	are	be	AUX
biomedich-811	58	32	mostly	mostly	ADV
biomedich-811	58	33	seasonal	seasonal	ADJ
biomedich-811	58	34	workers	worker	NOUN
biomedich-811	58	35	from	from	ADP
biomedich-811	58	36	papua	papua	PROPN
biomedich-811	58	37	or	or	CCONJ
biomedich-811	58	38	maluku	maluku	PROPN
biomedich-811	58	39	,	,	PUNCT
biomedich-811	58	40	and	and	CCONJ
biomedich-811	58	41	the	the	DET
biomedich-811	58	42	second	second	ADJ
biomedich-811	58	43	was	be	AUX
biomedich-811	58	44	malaria	malaria	NOUN
biomedich-811	58	45	patients	patient	NOUN
biomedich-811	58	46	directly	directly	ADV
biomedich-811	58	47	from	from	ADP
biomedich-811	58	48	some	some	DET
biomedich-811	58	49	districts	district	NOUN
biomedich-811	58	50	in	in	ADP
biomedich-811	58	51	kerom	kerom	PROPN
biomedich-811	58	52	regency	regency	PROPN
biomedich-811	58	53	,	,	PUNCT
biomedich-811	58	54	papua	papua	PROPN
biomedich-811	58	55	province	province	PROPN
biomedich-811	58	56	.	.	PUNCT
biomedich-811	59	1	patients	patient	NOUN
biomedich-811	59	2	were	be	AUX
biomedich-811	59	3	diagnosed	diagnose	VERB
biomedich-811	59	4	with	with	ADP
biomedich-811	59	5	malaria	malaria	NOUN
biomedich-811	59	6	based	base	VERB
biomedich-811	59	7	on	on	ADP
biomedich-811	59	8	clinical	clinical	ADJ
biomedich-811	59	9	signs	sign	NOUN
biomedich-811	59	10	and	and	CCONJ
biomedich-811	59	11	symptoms	symptom	NOUN
biomedich-811	59	12	and	and	CCONJ
biomedich-811	59	13	blood	blood	NOUN
biomedich-811	59	14	smear	smear	VERB
biomedich-811	59	15	microscopic	microscopic	ADJ
biomedich-811	59	16	examination	examination	NOUN
biomedich-811	59	17	.	.	PUNCT
biomedich-811	60	1	ethical	ethical	ADJ
biomedich-811	60	2	clearance	clearance	NOUN
biomedich-811	60	3	all	all	DET
biomedich-811	60	4	procedures	procedure	NOUN
biomedich-811	60	5	in	in	ADP
biomedich-811	60	6	this	this	DET
biomedich-811	60	7	research	research	NOUN
biomedich-811	60	8	have	have	AUX
biomedich-811	60	9	been	be	AUX
biomedich-811	60	10	approved	approve	VERB
biomedich-811	60	11	by	by	ADP
biomedich-811	60	12	the	the	DET
biomedich-811	60	13	ethical	ethical	PROPN
biomedich-811	60	14	committee	committee	NOUN
biomedich-811	60	15	of	of	ADP
biomedich-811	60	16	research	research	NOUN
biomedich-811	60	17	faculty	faculty	NOUN
biomedich-811	60	18	of	of	ADP
biomedich-811	60	19	medicine	medicine	NOUN
biomedich-811	60	20	,	,	PUNCT
biomedich-811	60	21	university	university	NOUN
biomedich-811	60	22	of	of	ADP
biomedich-811	60	23	jember	jember	PROPN
biomedich-811	60	24	no	no	INTJ
biomedich-811	60	25	.	.	PUNCT
biomedich-811	60	26	2103	2103	NUM
biomedich-811	60	27	/	/	SYM
biomedich-811	60	28	un25.1.10.2	un25.1.10.2	NOUN
biomedich-811	60	29	/	/	SYM
biomedich-811	60	30	ke/2024	ke/2024	PROPN
biomedich-811	60	31	.	.	PUNCT
biomedich-811	61	1	patients	patient	NOUN
biomedich-811	61	2	received	receive	VERB
biomedich-811	61	3	a	a	DET
biomedich-811	61	4	clear	clear	ADJ
biomedich-811	61	5	explanation	explanation	NOUN
biomedich-811	61	6	about	about	ADP
biomedich-811	61	7	the	the	DET
biomedich-811	61	8	study	study	NOUN
biomedich-811	61	9	before	before	ADP
biomedich-811	61	10	signing	sign	VERB
biomedich-811	61	11	an	an	DET
biomedich-811	61	12	informed	informed	ADJ
biomedich-811	61	13	consent	consent	NOUN
biomedich-811	61	14	form	form	NOUN
biomedich-811	61	15	to	to	PART
biomedich-811	61	16	participate	participate	VERB
biomedich-811	61	17	in	in	ADP
biomedich-811	61	18	the	the	DET
biomedich-811	61	19	study	study	NOUN
biomedich-811	61	20	.	.	PUNCT
biomedich-811	62	1	study	study	NOUN
biomedich-811	62	2	sample	sample	NOUN
biomedich-811	62	3	malaria	malaria	NOUN
biomedich-811	62	4	patient	patient	NOUN
biomedich-811	62	5	was	be	AUX
biomedich-811	62	6	determined	determine	VERB
biomedich-811	62	7	based	base	VERB
biomedich-811	62	8	on	on	ADP
biomedich-811	62	9	clinical	clinical	ADJ
biomedich-811	62	10	signs	sign	NOUN
biomedich-811	62	11	and	and	CCONJ
biomedich-811	62	12	symptoms	symptom	NOUN
biomedich-811	62	13	and	and	CCONJ
biomedich-811	62	14	confirmed	confirm	VERB
biomedich-811	62	15	by	by	ADP
biomedich-811	62	16	blood	blood	NOUN
biomedich-811	62	17	smear	smear	NOUN
biomedich-811	62	18	examination	examination	NOUN
biomedich-811	62	19	.	.	PUNCT
biomedich-811	63	1	blood	blood	NOUN
biomedich-811	63	2	samples	sample	NOUN
biomedich-811	63	3	of	of	ADP
biomedich-811	63	4	malaria	malaria	NOUN
biomedich-811	63	5	patients	patient	NOUN
biomedich-811	63	6	were	be	AUX
biomedich-811	63	7	collected	collect	VERB
biomedich-811	63	8	before	before	ADP
biomedich-811	63	9	treatment	treatment	NOUN
biomedich-811	63	10	.	.	PUNCT
biomedich-811	64	1	blood	blood	NOUN
biomedich-811	64	2	samples	sample	NOUN
biomedich-811	64	3	were	be	AUX
biomedich-811	64	4	dropped	drop	VERB
biomedich-811	64	5	on	on	ADP
biomedich-811	64	6	the	the	DET
biomedich-811	64	7	whatmann	whatmann	NOUN
biomedich-811	64	8	filter	filter	NOUN
biomedich-811	64	9	paper	paper	NOUN
biomedich-811	64	10	,	,	PUNCT
biomedich-811	64	11	dried	dry	VERB
biomedich-811	64	12	at	at	ADP
biomedich-811	64	13	room	room	NOUN
biomedich-811	64	14	temperature	temperature	NOUN
biomedich-811	64	15	,	,	PUNCT
biomedich-811	64	16	and	and	CCONJ
biomedich-811	64	17	put	put	VERB
biomedich-811	64	18	in	in	ADP
biomedich-811	64	19	the	the	DET
biomedich-811	64	20	zipped	zipped	ADJ
biomedich-811	64	21	plastic	plastic	NOUN
biomedich-811	64	22	bag	bag	NOUN
biomedich-811	64	23	until	until	SCONJ
biomedich-811	64	24	dna	dna	PROPN
biomedich-811	64	25	isolation	isolation	NOUN
biomedich-811	64	26	was	be	AUX
biomedich-811	64	27	performed	perform	VERB
biomedich-811	64	28	.	.	PUNCT
biomedich-811	65	1	sulistyaningsih	sulistyaningsih	PROPN
biomedich-811	65	2	et	et	PROPN
biomedich-811	65	3	al	al	PROPN
biomedich-811	65	4	.	.	PROPN
biomedich-811	65	5	–	–	PUNCT
biomedich-811	65	6	molecular	molecular	ADJ
biomedich-811	65	7	method	method	NOUN
biomedich-811	65	8	optimization	optimization	NOUN
biomedich-811	65	9	to	to	PART
biomedich-811	65	10	identify	identify	VERB
biomedich-811	65	11	plasmodium	plasmodium	NOUN
biomedich-811	65	12	falciparum	falciparum	NOUN
biomedich-811	65	13	…	…	PUNCT
biomedich-811	65	14	675	675	NUM
biomedich-811	65	15	dna	dna	NOUN
biomedich-811	65	16	isolation	isolation	NOUN
biomedich-811	65	17	dna	dna	NOUN
biomedich-811	65	18	isolation	isolation	NOUN
biomedich-811	65	19	was	be	AUX
biomedich-811	65	20	conducted	conduct	VERB
biomedich-811	65	21	using	use	VERB
biomedich-811	65	22	a	a	DET
biomedich-811	65	23	qiamp	qiamp	ADJ
biomedich-811	65	24	dna	dna	PROPN
biomedich-811	65	25	blood	blood	NOUN
biomedich-811	65	26	mini	mini	NOUN
biomedich-811	65	27	kit	kit	NOUN
biomedich-811	65	28	(	(	PUNCT
biomedich-811	65	29	qiagen	qiagen	NOUN
biomedich-811	65	30	,	,	PUNCT
biomedich-811	65	31	2007	2007	NUM
biomedich-811	65	32	)	)	PUNCT
biomedich-811	65	33	.	.	PUNCT
biomedich-811	66	1	the	the	DET
biomedich-811	66	2	procedures	procedure	NOUN
biomedich-811	66	3	were	be	AUX
biomedich-811	66	4	performed	perform	VERB
biomedich-811	66	5	based	base	VERB
biomedich-811	66	6	on	on	ADP
biomedich-811	66	7	the	the	DET
biomedich-811	66	8	manufacturer	manufacturer	NOUN
biomedich-811	66	9	's	's	PART
biomedich-811	66	10	protocol	protocol	NOUN
biomedich-811	66	11	.	.	PUNCT
biomedich-811	67	1	as	as	ADV
biomedich-811	67	2	many	many	ADJ
biomedich-811	67	3	as	as	ADP
biomedich-811	67	4	three	three	NUM
biomedich-811	67	5	punches	punch	NOUN
biomedich-811	67	6	of	of	ADP
biomedich-811	67	7	3	3	NUM
biomedich-811	67	8	mm	mm	NOUN
biomedich-811	67	9	dried	dry	VERB
biomedich-811	67	10	blood	blood	NOUN
biomedich-811	67	11	spot	spot	NOUN
biomedich-811	67	12	were	be	AUX
biomedich-811	67	13	put	put	VERB
biomedich-811	67	14	in	in	ADP
biomedich-811	67	15	the	the	DET
biomedich-811	67	16	tube	tube	NOUN
biomedich-811	67	17	for	for	ADP
biomedich-811	67	18	dna	dna	NOUN
biomedich-811	67	19	isolation	isolation	NOUN
biomedich-811	67	20	and	and	CCONJ
biomedich-811	67	21	added	add	VERB
biomedich-811	67	22	with	with	ADP
biomedich-811	67	23	prelysis	prelysis	NOUN
biomedich-811	67	24	buffer	buffer	NOUN
biomedich-811	67	25	(	(	PUNCT
biomedich-811	67	26	atl	atl	PROPN
biomedich-811	67	27	)	)	PUNCT
biomedich-811	67	28	and	and	CCONJ
biomedich-811	67	29	proteinase	proteinase	PROPN
biomedich-811	67	30	-	-	PUNCT
biomedich-811	67	31	k.	k.	NOUN
biomedich-811	67	32	the	the	DET
biomedich-811	67	33	tube	tube	NOUN
biomedich-811	67	34	was	be	AUX
biomedich-811	67	35	heated	heat	VERB
biomedich-811	67	36	by	by	ADP
biomedich-811	67	37	incubation	incubation	NOUN
biomedich-811	67	38	at	at	ADP
biomedich-811	67	39	56oc	56oc	ADV
biomedich-811	67	40	with	with	ADP
biomedich-811	67	41	900	900	NUM
biomedich-811	67	42	rpm	rpm	NOUN
biomedich-811	67	43	shaking	shake	VERB
biomedich-811	67	44	for	for	ADP
biomedich-811	67	45	1	1	NUM
biomedich-811	67	46	hour	hour	NOUN
biomedich-811	67	47	.	.	PUNCT
biomedich-811	68	1	the	the	DET
biomedich-811	68	2	tube	tube	NOUN
biomedich-811	68	3	was	be	AUX
biomedich-811	68	4	added	add	VERB
biomedich-811	68	5	with	with	ADP
biomedich-811	68	6	lysis	lysis	NOUN
biomedich-811	68	7	buffer	buffer	NOUN
biomedich-811	68	8	(	(	PUNCT
biomedich-811	68	9	al	al	PROPN
biomedich-811	68	10	)	)	PUNCT
biomedich-811	68	11	and	and	CCONJ
biomedich-811	68	12	incubated	incubate	VERB
biomedich-811	68	13	at	at	ADP
biomedich-811	68	14	70oc	70oc	NOUN
biomedich-811	68	15	for	for	ADP
biomedich-811	68	16	10	10	NUM
biomedich-811	68	17	min	min	NOUN
biomedich-811	68	18	with	with	ADP
biomedich-811	68	19	900	900	NUM
biomedich-811	68	20	rpm	rpm	NOUN
biomedich-811	68	21	shaking	shaking	NOUN
biomedich-811	68	22	.	.	PUNCT
biomedich-811	69	1	the	the	DET
biomedich-811	69	2	lysate	lysate	NOUN
biomedich-811	69	3	was	be	AUX
biomedich-811	69	4	then	then	ADV
biomedich-811	69	5	transferred	transfer	VERB
biomedich-811	69	6	into	into	ADP
biomedich-811	69	7	the	the	DET
biomedich-811	69	8	mini	mini	NOUN
biomedich-811	69	9	-	-	NOUN
biomedich-811	69	10	column	column	NOUN
biomedich-811	69	11	and	and	CCONJ
biomedich-811	69	12	centrifuged	centrifuge	VERB
biomedich-811	69	13	at	at	ADP
biomedich-811	69	14	8000	8000	NUM
biomedich-811	69	15	rpm	rpm	NOUN
biomedich-811	69	16	for	for	ADP
biomedich-811	69	17	1	1	NUM
biomedich-811	69	18	min	min	NOUN
biomedich-811	69	19	.	.	PUNCT
biomedich-811	70	1	the	the	DET
biomedich-811	70	2	column	column	NOUN
biomedich-811	70	3	was	be	AUX
biomedich-811	70	4	then	then	ADV
biomedich-811	70	5	added	add	VERB
biomedich-811	70	6	with	with	ADP
biomedich-811	70	7	washing	washing	NOUN
biomedich-811	70	8	buffer	buffer	NOUN
biomedich-811	70	9	1	1	NUM
biomedich-811	70	10	(	(	PUNCT
biomedich-811	70	11	aw1	aw1	PROPN
biomedich-811	70	12	)	)	PUNCT
biomedich-811	70	13	,	,	PUNCT
biomedich-811	70	14	centrifuged	centrifuge	VERB
biomedich-811	70	15	again	again	ADV
biomedich-811	70	16	,	,	PUNCT
biomedich-811	70	17	and	and	CCONJ
biomedich-811	70	18	further	far	ADV
biomedich-811	70	19	washed	wash	VERB
biomedich-811	70	20	using	use	VERB
biomedich-811	70	21	washing	washing	NOUN
biomedich-811	70	22	buffer	buffer	NOUN
biomedich-811	70	23	2	2	NUM
biomedich-811	70	24	(	(	PUNCT
biomedich-811	70	25	aw2	aw2	PROPN
biomedich-811	70	26	)	)	PUNCT
biomedich-811	70	27	.	.	PUNCT
biomedich-811	71	1	the	the	DET
biomedich-811	71	2	column	column	NOUN
biomedich-811	71	3	was	be	AUX
biomedich-811	71	4	dried	dry	VERB
biomedich-811	71	5	by	by	ADP
biomedich-811	71	6	high	high	ADJ
biomedich-811	71	7	-	-	PUNCT
biomedich-811	71	8	speed	speed	NOUN
biomedich-811	71	9	centrifugation	centrifugation	NOUN
biomedich-811	71	10	at	at	ADP
biomedich-811	71	11	14.000	14.000	NUM
biomedich-811	71	12	rpm	rpm	NOUN
biomedich-811	71	13	for	for	ADP
biomedich-811	71	14	3	3	NUM
biomedich-811	71	15	min	min	NOUN
biomedich-811	71	16	.	.	PROPN
biomedich-811	71	17	finally	finally	ADV
biomedich-811	71	18	,	,	PUNCT
biomedich-811	71	19	the	the	DET
biomedich-811	71	20	dna	dna	NOUN
biomedich-811	71	21	was	be	AUX
biomedich-811	71	22	eluted	elute	VERB
biomedich-811	71	23	from	from	ADP
biomedich-811	71	24	the	the	DET
biomedich-811	71	25	column	column	NOUN
biomedich-811	71	26	using	use	VERB
biomedich-811	71	27	elution	elution	NOUN
biomedich-811	71	28	buffer	buffer	NOUN
biomedich-811	71	29	(	(	PUNCT
biomedich-811	71	30	ae	ae	PROPN
biomedich-811	71	31	)	)	PUNCT
biomedich-811	71	32	by	by	ADP
biomedich-811	71	33	14.000	14.000	NUM
biomedich-811	71	34	rpm	rpm	NOUN
biomedich-811	71	35	centrifugation	centrifugation	NOUN
biomedich-811	71	36	for	for	ADP
biomedich-811	71	37	1	1	NUM
biomedich-811	71	38	min	min	NOUN
biomedich-811	71	39	.	.	PUNCT
biomedich-811	72	1	the	the	DET
biomedich-811	72	2	dna	dna	PROPN
biomedich-811	72	3	isolation	isolation	NOUN
biomedich-811	72	4	result	result	NOUN
biomedich-811	72	5	was	be	AUX
biomedich-811	72	6	then	then	ADV
biomedich-811	72	7	evaluated	evaluate	VERB
biomedich-811	72	8	using	use	VERB
biomedich-811	72	9	1	1	NUM
biomedich-811	72	10	%	%	NOUN
biomedich-811	72	11	agarose	agarose	NOUN
biomedich-811	72	12	gel	gel	NOUN
biomedich-811	72	13	electrophoresis	electrophoresis	NOUN
biomedich-811	72	14	,	,	PUNCT
biomedich-811	72	15	quantified	quantify	VERB
biomedich-811	72	16	using	use	VERB
biomedich-811	72	17	spectrophotometry	spectrophotometry	NOUN
biomedich-811	72	18	,	,	PUNCT
biomedich-811	72	19	and	and	CCONJ
biomedich-811	72	20	saved	save	VERB
biomedich-811	72	21	at	at	ADP
biomedich-811	72	22	-20oc	-20oc	PROPN
biomedich-811	72	23	until	until	SCONJ
biomedich-811	72	24	used	use	VERB
biomedich-811	72	25	for	for	ADP
biomedich-811	72	26	amplification	amplification	NOUN
biomedich-811	72	27	.	.	PUNCT
biomedich-811	73	1	pcr	pcr	ADJ
biomedich-811	73	2	amplification	amplification	NOUN
biomedich-811	73	3	the	the	DET
biomedich-811	73	4	pfmdr1	pfmdr1	PROPN
biomedich-811	73	5	gene	gene	PROPN
biomedich-811	73	6	was	be	AUX
biomedich-811	73	7	identified	identify	VERB
biomedich-811	73	8	using	use	VERB
biomedich-811	73	9	two	two	NUM
biomedich-811	73	10	types	type	NOUN
biomedich-811	73	11	of	of	ADP
biomedich-811	73	12	specific	specific	ADJ
biomedich-811	73	13	primers	primer	NOUN
biomedich-811	73	14	,	,	PUNCT
biomedich-811	73	15	namely	namely	ADV
biomedich-811	73	16	pfmdr1	pfmdr1	PROPN
biomedich-811	73	17	-	-	PUNCT
biomedich-811	73	18	a	a	PROPN
biomedich-811	73	19	and	and	CCONJ
biomedich-811	73	20	pfmdr1	pfmdr1	PROPN
biomedich-811	73	21	-	-	PUNCT
biomedich-811	73	22	b.	b.	PROPN
biomedich-811	73	23	both	both	DET
biomedich-811	73	24	primer	primer	NOUN
biomedich-811	73	25	pairs	pair	NOUN
biomedich-811	73	26	were	be	AUX
biomedich-811	73	27	conducted	conduct	VERB
biomedich-811	73	28	using	use	VERB
biomedich-811	73	29	nested	nested	ADJ
biomedich-811	73	30	pcr	pcr	NOUN
biomedich-811	73	31	techniques	technique	NOUN
biomedich-811	73	32	using	use	VERB
biomedich-811	73	33	the	the	DET
biomedich-811	73	34	mytaq	mytaq	ADV
biomedich-811	73	35	hs	hs	PROPN
biomedich-811	73	36	red	red	ADJ
biomedich-811	73	37	mix	mix	NOUN
biomedich-811	73	38	(	(	PUNCT
biomedich-811	73	39	bioline	bioline	NOUN
biomedich-811	73	40	)	)	PUNCT
biomedich-811	73	41	(	(	PUNCT
biomedich-811	73	42	table	table	NOUN
biomedich-811	73	43	1	1	NUM
biomedich-811	73	44	)	)	PUNCT
biomedich-811	73	45	.	.	PUNCT
biomedich-811	74	1	in	in	ADP
biomedich-811	74	2	this	this	DET
biomedich-811	74	3	study	study	NOUN
biomedich-811	74	4	,	,	PUNCT
biomedich-811	74	5	we	we	PRON
biomedich-811	74	6	did	do	VERB
biomedich-811	74	7	pcr	pcr	ADJ
biomedich-811	74	8	optimization	optimization	NOUN
biomedich-811	74	9	,	,	PUNCT
biomedich-811	74	10	especially	especially	ADV
biomedich-811	74	11	during	during	ADP
biomedich-811	74	12	the	the	DET
biomedich-811	74	13	pcr	pcr	ADJ
biomedich-811	74	14	cycle	cycle	NOUN
biomedich-811	74	15	,	,	PUNCT
biomedich-811	74	16	based	base	VERB
biomedich-811	74	17	on	on	ADP
biomedich-811	74	18	previous	previous	ADJ
biomedich-811	74	19	studies	study	NOUN
biomedich-811	74	20	.	.	PUNCT
biomedich-811	75	1	the	the	DET
biomedich-811	75	2	pcr	pcr	ADJ
biomedich-811	75	3	results	result	NOUN
biomedich-811	75	4	were	be	AUX
biomedich-811	75	5	visualized	visualize	VERB
biomedich-811	75	6	on	on	ADP
biomedich-811	75	7	1	1	NUM
biomedich-811	75	8	%	%	NOUN
biomedich-811	75	9	agarose	agarose	NOUN
biomedich-811	75	10	gel	gel	NOUN
biomedich-811	75	11	electrophoresis	electrophoresis	NOUN
biomedich-811	75	12	.	.	PUNCT
biomedich-811	76	1	table	table	NOUN
biomedich-811	76	2	1	1	NUM
biomedich-811	76	3	.	.	PUNCT
biomedich-811	77	1	the	the	DET
biomedich-811	77	2	primers	primer	NOUN
biomedich-811	77	3	and	and	CCONJ
biomedich-811	77	4	cycles	cycle	NOUN
biomedich-811	77	5	to	to	PART
biomedich-811	77	6	identify	identify	VERB
biomedich-811	77	7	the	the	DET
biomedich-811	77	8	pfmdr1	pfmdr1	PROPN
biomedich-811	77	9	gene	gene	PROPN
biomedich-811	77	10	.	.	PUNCT
biomedich-811	78	1	gen	gen	PROPN
biomedich-811	78	2	pcr	pcr	PROPN
biomedich-811	78	3	and	and	CCONJ
biomedich-811	78	4	primer	primer	NOUN
biomedich-811	78	5	’s	’s	PART
biomedich-811	78	6	name	name	NOUN
biomedich-811	78	7	sequences	sequence	NOUN
biomedich-811	78	8	(	(	PUNCT
biomedich-811	78	9	5	5	NUM
biomedich-811	78	10	’	'	PUNCT
biomedich-811	78	11	to	to	ADP
biomedich-811	78	12	3	3	NUM
biomedich-811	78	13	’	'	PUNCT
biomedich-811	78	14	)	)	PUNCT
biomedich-811	78	15	target	target	NOUN
biomedich-811	78	16	amplicon	amplicon	NOUN
biomedich-811	78	17	(	(	PUNCT
biomedich-811	78	18	bp	bp	PROPN
biomedich-811	78	19	)	)	PUNCT
biomedich-811	78	20	cycle	cycle	NOUN
biomedich-811	78	21	pfmdr1	pfmdr1	PROPN
biomedich-811	78	22	-	-	PUNCT
biomedich-811	78	23	a	a	PRON
biomedich-811	78	24	nested	nested	ADJ
biomedich-811	78	25	1	1	NUM
biomedich-811	78	26	:	:	PUNCT
biomedich-811	78	27	mdr1a	mdr1a	NUM
biomedich-811	78	28	-	-	PUNCT
biomedich-811	78	29	f	f	NOUN
biomedich-811	78	30	mdr1a	mdr1a	PROPN
biomedich-811	78	31	-	-	PUNCT
biomedich-811	78	32	r	r	NOUN
biomedich-811	78	33	gtgtatttgctgtaagagct	gtgtatttgctgtaagagct	PROPN
biomedich-811	78	34	gacatattaaataacatgggttc	gacatattaaataacatgggttc	NOUN
biomedich-811	78	35	958	958	NUM
biomedich-811	78	36	94oc	94oc	ADJ
biomedich-811	78	37	3min	3min	NOUN
biomedich-811	78	38	,	,	PUNCT
biomedich-811	78	39	(	(	PUNCT
biomedich-811	78	40	94oc	94oc	ADJ
biomedich-811	78	41	30s	30	NOUN
biomedich-811	78	42	,	,	PUNCT
biomedich-811	78	43	55oc	55oc	NOUN
biomedich-811	78	44	60s	60	NOUN
biomedich-811	78	45	,	,	PUNCT
biomedich-811	78	46	65oc	65oc	NOUN
biomedich-811	78	47	90s	90	NOUN
biomedich-811	78	48	)	)	PUNCT
biomedich-811	78	49	34	34	NUM
biomedich-811	78	50	cycles	cycle	NOUN
biomedich-811	78	51	,	,	PUNCT
biomedich-811	78	52	65oc	65oc	NOUN
biomedich-811	78	53	5	5	NUM
biomedich-811	78	54	min	min	NOUN
biomedich-811	78	55	,	,	PUNCT
biomedich-811	78	56	4oc	4oc	ADJ
biomedich-811	78	57	5min	5min	NOUN
biomedich-811	78	58	(	(	PUNCT
biomedich-811	78	59	adamu	adamu	PROPN
biomedich-811	78	60	et	et	PROPN
biomedich-811	78	61	al	al	PROPN
biomedich-811	78	62	.	.	PROPN
biomedich-811	78	63	,	,	PUNCT
biomedich-811	78	64	2020	2020	NUM
biomedich-811	78	65	)	)	PUNCT
biomedich-811	78	66	nested	nest	VERB
biomedich-811	78	67	2	2	NUM
biomedich-811	78	68	:	:	PUNCT
biomedich-811	78	69	mdr2a	mdr2a	PROPN
biomedich-811	78	70	-	-	PUNCT
biomedich-811	78	71	f	f	NOUN
biomedich-811	78	72	mdr2a	mdr2a	PROPN
biomedich-811	78	73	-	-	PUNCT
biomedich-811	78	74	r	r	NOUN
biomedich-811	78	75	cagatgatgaaatgtttaaagatc	cagatgatgaaatgtttaaagatc	NOUN
biomedich-811	78	76	taaataacatgggttcttgact	taaataacatgggttcttgact	PROPN
biomedich-811	78	77	864	864	NUM
biomedich-811	78	78	94oc	94oc	ADJ
biomedich-811	78	79	3min	3min	NOUN
biomedich-811	78	80	,	,	PUNCT
biomedich-811	78	81	(	(	PUNCT
biomedich-811	78	82	94oc	94oc	ADJ
biomedich-811	78	83	30s	30	NOUN
biomedich-811	78	84	,	,	PUNCT
biomedich-811	78	85	60oc	60oc	ADJ
biomedich-811	78	86	30s	30	NOUN
biomedich-811	78	87	,	,	PUNCT
biomedich-811	78	88	65oc	65oc	NOUN
biomedich-811	78	89	60s	60	NOUN
biomedich-811	78	90	)	)	PUNCT
biomedich-811	78	91	28	28	NUM
biomedich-811	78	92	cycles	cycle	NOUN
biomedich-811	78	93	,	,	PUNCT
biomedich-811	78	94	65oc	65oc	ADJ
biomedich-811	78	95	5	5	NUM
biomedich-811	78	96	min	min	NOUN
biomedich-811	78	97	,	,	PUNCT
biomedich-811	78	98	4oc	4oc	ADJ
biomedich-811	78	99	5min	5min	NOUN
biomedich-811	78	100	(	(	PUNCT
biomedich-811	78	101	adamu	adamu	PROPN
biomedich-811	78	102	et	et	PROPN
biomedich-811	78	103	al	al	PROPN
biomedich-811	78	104	.	.	PROPN
biomedich-811	78	105	,	,	PUNCT
biomedich-811	78	106	2020	2020	NUM
biomedich-811	78	107	)	)	PUNCT
biomedich-811	78	108	pfmdr1	pfmdr1	PROPN
biomedich-811	78	109	-	-	PUNCT
biomedich-811	78	110	b	b	PROPN
biomedich-811	78	111	nested	nest	VERB
biomedich-811	78	112	1	1	NUM
biomedich-811	78	113	:	:	PUNCT
biomedich-811	78	114	mdr1b	mdr1b	NOUN
biomedich-811	78	115	-	-	NOUN
biomedich-811	78	116	f	f	ADJ
biomedich-811	78	117	mdr1b	mdr1b	PROPN
biomedich-811	78	118	-	-	PUNCT
biomedich-811	78	119	r	r	VERB
biomedich-811	78	120	aggttgaaaaagagttgaac	aggttgaaaaagagttgaac	NOUN
biomedich-811	78	121	atgacaccacaaacataaat	atgacaccacaaacataaat	NOUN
biomedich-811	78	122	578	578	NUM
biomedich-811	78	123	94oc	94oc	ADJ
biomedich-811	78	124	3min	3min	NOUN
biomedich-811	78	125	,	,	PUNCT
biomedich-811	78	126	(	(	PUNCT
biomedich-811	78	127	94oc	94oc	ADJ
biomedich-811	78	128	30s	30	NOUN
biomedich-811	78	129	,	,	PUNCT
biomedich-811	78	130	55oc	55oc	ADJ
biomedich-811	78	131	30s	30	NOUN
biomedich-811	78	132	,	,	PUNCT
biomedich-811	78	133	65oc	65oc	NOUN
biomedich-811	78	134	60s	60	NOUN
biomedich-811	78	135	)	)	PUNCT
biomedich-811	78	136	34	34	NUM
biomedich-811	78	137	cycles	cycle	NOUN
biomedich-811	78	138	,	,	PUNCT
biomedich-811	78	139	65oc	65oc	NOUN
biomedich-811	78	140	5	5	NUM
biomedich-811	78	141	min	min	NOUN
biomedich-811	78	142	,	,	PUNCT
biomedich-811	78	143	4oc	4oc	ADJ
biomedich-811	78	144	5min	5min	NOUN
biomedich-811	78	145	(	(	PUNCT
biomedich-811	78	146	adamu	adamu	PROPN
biomedich-811	78	147	et	et	PROPN
biomedich-811	78	148	al	al	PROPN
biomedich-811	78	149	.	.	PROPN
biomedich-811	78	150	,	,	PUNCT
biomedich-811	78	151	2020	2020	NUM
biomedich-811	78	152	)	)	PUNCT
biomedich-811	78	153	nested	nest	VERB
biomedich-811	78	154	2	2	NUM
biomedich-811	78	155	:	:	PUNCT
biomedich-811	78	156	mdr2b	mdr2b	NOUN
biomedich-811	78	157	-	-	PUNCT
biomedich-811	78	158	f	f	NOUN
biomedich-811	78	159	mdr2b	mdr2b	PROPN
biomedich-811	78	160	-	-	PUNCT
biomedich-811	78	161	r	r	NOUN
biomedich-811	78	162	acaaaaagagtaccgctgaat	acaaaaagagtaccgctgaat	NOUN
biomedich-811	78	163	aaacgcaagtaatacataaagtc	aaacgcaagtaatacataaagtc	NOUN
biomedich-811	78	164	534	534	NUM
biomedich-811	78	165	94oc	94oc	ADJ
biomedich-811	78	166	3min	3min	NOUN
biomedich-811	78	167	,	,	PUNCT
biomedich-811	78	168	(	(	PUNCT
biomedich-811	78	169	94oc	94oc	ADJ
biomedich-811	78	170	30s	30	NOUN
biomedich-811	78	171	,	,	PUNCT
biomedich-811	78	172	60oc	60oc	ADJ
biomedich-811	78	173	30s	30	NOUN
biomedich-811	78	174	,	,	PUNCT
biomedich-811	78	175	65oc	65oc	NOUN
biomedich-811	78	176	60s	60	NOUN
biomedich-811	78	177	)	)	PUNCT
biomedich-811	78	178	29	29	NUM
biomedich-811	78	179	cycles	cycle	NOUN
biomedich-811	78	180	,	,	PUNCT
biomedich-811	78	181	65oc	65oc	ADJ
biomedich-811	78	182	5	5	NUM
biomedich-811	78	183	min	min	NOUN
biomedich-811	78	184	,	,	PUNCT
biomedich-811	78	185	4oc	4oc	ADJ
biomedich-811	78	186	5min	5min	NOUN
biomedich-811	78	187	(	(	PUNCT
biomedich-811	78	188	adamu	adamu	PROPN
biomedich-811	78	189	et	et	PROPN
biomedich-811	78	190	al	al	PROPN
biomedich-811	78	191	.	.	PROPN
biomedich-811	78	192	,	,	PUNCT
biomedich-811	78	193	2020	2020	NUM
biomedich-811	78	194	)	)	PUNCT
biomedich-811	78	195	results	result	NOUN
biomedich-811	78	196	and	and	CCONJ
biomedich-811	78	197	discussion	discussion	NOUN
biomedich-811	78	198	the	the	DET
biomedich-811	78	199	study	study	NOUN
biomedich-811	78	200	included	include	VERB
biomedich-811	78	201	53	53	NUM
biomedich-811	78	202	malaria	malaria	NOUN
biomedich-811	78	203	patients	patient	NOUN
biomedich-811	78	204	,	,	PUNCT
biomedich-811	78	205	with	with	ADP
biomedich-811	78	206	50	50	NUM
biomedich-811	78	207	patients	patient	NOUN
biomedich-811	78	208	who	who	PRON
biomedich-811	78	209	had	have	VERB
biomedich-811	78	210	uncomplicated	uncomplicated	ADJ
biomedich-811	78	211	malaria	malaria	NOUN
biomedich-811	78	212	from	from	ADP
biomedich-811	78	213	health	health	NOUN
biomedich-811	78	214	services	service	NOUN
biomedich-811	78	215	in	in	ADP
biomedich-811	78	216	kerom	kerom	PROPN
biomedich-811	78	217	regency	regency	PROPN
biomedich-811	78	218	,	,	PUNCT
biomedich-811	78	219	papua	papua	PROPN
biomedich-811	78	220	province	province	PROPN
biomedich-811	78	221	,	,	PUNCT
biomedich-811	78	222	with	with	ADP
biomedich-811	78	223	the	the	DET
biomedich-811	78	224	main	main	ADJ
biomedich-811	78	225	symptoms	symptom	NOUN
biomedich-811	78	226	being	be	AUX
biomedich-811	78	227	fever	fever	NOUN
biomedich-811	78	228	,	,	PUNCT
biomedich-811	78	229	chills	chill	NOUN
biomedich-811	78	230	,	,	PUNCT
biomedich-811	78	231	and	and	CCONJ
biomedich-811	78	232	nausea	nausea	NOUN
biomedich-811	78	233	.	.	PUNCT
biomedich-811	79	1	the	the	DET
biomedich-811	79	2	other	other	ADJ
biomedich-811	79	3	three	three	NUM
biomedich-811	79	4	patients	patient	NOUN
biomedich-811	79	5	were	be	AUX
biomedich-811	79	6	severe	severe	ADJ
biomedich-811	79	7	or	or	CCONJ
biomedich-811	79	8	complicated	complicated	ADJ
biomedich-811	79	9	malaria	malaria	NOUN
biomedich-811	79	10	patients	patient	NOUN
biomedich-811	79	11	from	from	ADP
biomedich-811	79	12	dr	dr	PROPN
biomedich-811	79	13	.	.	PROPN
biomedich-811	79	14	soebandi	soebandi	PROPN
biomedich-811	79	15	hospital	hospital	PROPN
biomedich-811	79	16	,	,	PUNCT
biomedich-811	79	17	east	east	PROPN
biomedich-811	79	18	java	java	PROPN
biomedich-811	79	19	province	province	PROPN
biomedich-811	79	20	,	,	PUNCT
biomedich-811	79	21	with	with	ADP
biomedich-811	79	22	malaria	malaria	NOUN
biomedich-811	79	23	complications	complication	NOUN
biomedich-811	79	24	,	,	PUNCT
biomedich-811	79	25	including	include	VERB
biomedich-811	79	26	severe	severe	ADJ
biomedich-811	79	27	anemia	anemia	NOUN
biomedich-811	79	28	,	,	PUNCT
biomedich-811	79	29	kidney	kidney	NOUN
biomedich-811	79	30	failure	failure	NOUN
biomedich-811	79	31	,	,	PUNCT
biomedich-811	79	32	and	and	CCONJ
biomedich-811	79	33	prostration	prostration	NOUN
biomedich-811	79	34	,	,	PUNCT
biomedich-811	79	35	based	base	VERB
biomedich-811	79	36	on	on	ADP
biomedich-811	79	37	who	who	PRON
biomedich-811	79	38	diagnosis	diagnosis	NOUN
biomedich-811	79	39	criteria	criterion	NOUN
biomedich-811	79	40	(	(	PUNCT
biomedich-811	79	41	table	table	NOUN
biomedich-811	79	42	2	2	NUM
biomedich-811	79	43	)	)	PUNCT
biomedich-811	79	44	(	(	PUNCT
biomedich-811	79	45	who	who	PRON
biomedich-811	79	46	,	,	PUNCT
biomedich-811	79	47	2014	2014	NUM
biomedich-811	79	48	)	)	PUNCT
biomedich-811	79	49	.	.	PUNCT
biomedich-811	80	1	patients	patient	NOUN
biomedich-811	80	2	'	'	PART
biomedich-811	80	3	diagnoses	diagnosis	NOUN
biomedich-811	80	4	were	be	AUX
biomedich-811	80	5	determined	determine	VERB
biomedich-811	80	6	based	base	VERB
biomedich-811	80	7	on	on	ADP
biomedich-811	80	8	clinical	clinical	ADJ
biomedich-811	80	9	signs	sign	NOUN
biomedich-811	80	10	and	and	CCONJ
biomedich-811	80	11	symptoms	symptom	NOUN
biomedich-811	80	12	,	,	PUNCT
biomedich-811	80	13	and	and	CCONJ
biomedich-811	80	14	the	the	DET
biomedich-811	80	15	microscopic	microscopic	ADJ
biomedich-811	80	16	examination	examination	NOUN
biomedich-811	80	17	was	be	AUX
biomedich-811	80	18	the	the	DET
biomedich-811	80	19	gold	gold	ADJ
biomedich-811	80	20	standard	standard	NOUN
biomedich-811	80	21	for	for	ADP
biomedich-811	80	22	malaria	malaria	NOUN
biomedich-811	80	23	diagnosis	diagnosis	NOUN
biomedich-811	80	24	by	by	ADP
biomedich-811	80	25	who	who	PRON
biomedich-811	80	26	(	(	PUNCT
biomedich-811	80	27	who	who	PRON
biomedich-811	80	28	,	,	PUNCT
biomedich-811	80	29	2024	2024	NUM
biomedich-811	80	30	)	)	PUNCT
biomedich-811	80	31	.	.	PUNCT
biomedich-811	81	1	all	all	DET
biomedich-811	81	2	patients	patient	NOUN
biomedich-811	81	3	from	from	ADP
biomedich-811	81	4	kerom	kerom	PROPN
biomedich-811	81	5	regency	regency	PROPN
biomedich-811	81	6	,	,	PUNCT
biomedich-811	81	7	papua	papua	PROPN
biomedich-811	81	8	province	province	PROPN
biomedich-811	81	9	,	,	PUNCT
biomedich-811	81	10	were	be	AUX
biomedich-811	81	11	outpatients	outpatient	NOUN
biomedich-811	81	12	who	who	PRON
biomedich-811	81	13	were	be	AUX
biomedich-811	81	14	admitted	admit	VERB
biomedich-811	81	15	to	to	ADP
biomedich-811	81	16	the	the	DET
biomedich-811	81	17	district	district	NOUN
biomedich-811	81	18	health	health	NOUN
biomedich-811	81	19	services	service	NOUN
biomedich-811	81	20	and	and	CCONJ
biomedich-811	81	21	had	have	VERB
biomedich-811	81	22	a	a	DET
biomedich-811	81	23	single	single	ADJ
biomedich-811	81	24	infection	infection	NOUN
biomedich-811	81	25	of	of	ADP
biomedich-811	81	26	p.	p.	NOUN
biomedich-811	81	27	falciparum	falciparum	PROPN
biomedich-811	81	28	based	base	VERB
biomedich-811	81	29	on	on	ADP
biomedich-811	81	30	microscopic	microscopic	ADJ
biomedich-811	81	31	examination	examination	NOUN
biomedich-811	81	32	.	.	PUNCT
biomedich-811	82	1	however	however	ADV
biomedich-811	82	2	,	,	PUNCT
biomedich-811	82	3	those	those	DET
biomedich-811	82	4	microscopical	microscopical	ADJ
biomedich-811	82	5	examinations	examination	NOUN
biomedich-811	82	6	were	be	AUX
biomedich-811	82	7	our	our	PRON
biomedich-811	82	8	secondary	secondary	ADJ
biomedich-811	82	9	data	datum	NOUN
biomedich-811	82	10	.	.	PUNCT
biomedich-811	83	1	data	datum	NOUN
biomedich-811	83	2	from	from	ADP
biomedich-811	83	3	dr	dr	PROPN
biomedich-811	83	4	.	.	PROPN
biomedich-811	83	5	soebandi	soebandi	PROPN
biomedich-811	83	6	hospital	hospital	PROPN
biomedich-811	83	7	showed	show	VERB
biomedich-811	83	8	a	a	DET
biomedich-811	83	9	single	single	ADJ
biomedich-811	83	10	infection	infection	NOUN
biomedich-811	83	11	of	of	ADP
biomedich-811	83	12	p.	p.	NOUN
biomedich-811	83	13	falciparum	falciparum	NOUN
biomedich-811	83	14	and	and	CCONJ
biomedich-811	83	15	a	a	DET
biomedich-811	83	16	mixed	mixed	ADJ
biomedich-811	83	17	infection	infection	NOUN
biomedich-811	83	18	of	of	ADP
biomedich-811	83	19	p.	p.	NOUN
biomedich-811	83	20	falciparum	falciparum	NOUN
biomedich-811	83	21	and	and	CCONJ
biomedich-811	83	22	p.	p.	PROPN
biomedich-811	83	23	vivax	vivax	PROPN
biomedich-811	83	24	(	(	PUNCT
biomedich-811	83	25	table	table	NOUN
biomedich-811	83	26	2	2	NUM
biomedich-811	83	27	)	)	PUNCT
biomedich-811	83	28	.	.	PUNCT
biomedich-811	84	1	table	table	NOUN
biomedich-811	84	2	2	2	NUM
biomedich-811	84	3	.	.	PUNCT
biomedich-811	85	1	characteristics	characteristic	NOUN
biomedich-811	85	2	of	of	ADP
biomedich-811	85	3	malaria	malaria	NOUN
biomedich-811	85	4	patients	patient	NOUN
biomedich-811	85	5	.	.	PUNCT
biomedich-811	86	1	frequency	frequency	NOUN
biomedich-811	86	2	percentage	percentage	NOUN
biomedich-811	86	3	(	(	PUNCT
biomedich-811	86	4	%	%	NOUN
biomedich-811	86	5	)	)	PUNCT
biomedich-811	86	6	origin	origin	PROPN
biomedich-811	86	7	dr	dr	PROPN
biomedich-811	86	8	.	.	PROPN
biomedich-811	86	9	soebandi	soebandi	PROPN
biomedich-811	86	10	hospital	hospital	PROPN
biomedich-811	86	11	kerom	kerom	PROPN
biomedich-811	86	12	regency	regency	PROPN
biomedich-811	86	13	,	,	PUNCT
biomedich-811	86	14	papua	papua	PROPN
biomedich-811	86	15	province	province	PROPN
biomedich-811	86	16	3	3	NUM
biomedich-811	86	17	50	50	NUM
biomedich-811	86	18	5.66	5.66	NUM
biomedich-811	86	19	94.34	94.34	NUM
biomedich-811	86	20	clinical	clinical	ADJ
biomedich-811	86	21	appearance	appearance	NOUN
biomedich-811	86	22	uncomplicated	uncomplicated	ADJ
biomedich-811	86	23	malaria	malaria	NOUN
biomedich-811	86	24	complicated	complicated	ADJ
biomedich-811	86	25	/	/	SYM
biomedich-811	86	26	severe	severe	ADJ
biomedich-811	86	27	malaria	malaria	NOUN
biomedich-811	86	28	50	50	NUM
biomedich-811	86	29	3	3	NUM
biomedich-811	86	30	94.34	94.34	NUM
biomedich-811	86	31	5.66	5.66	NUM
biomedich-811	86	32	microscpic	microscpic	NOUN
biomedich-811	86	33	examination	examination	NOUN
biomedich-811	86	34	p.	p.	NOUN
biomedich-811	86	35	falciparum	falciparum	NOUN
biomedich-811	87	1	p.	p.	NOUN
biomedich-811	88	1	falciparum	falciparum	PROPN
biomedich-811	89	1	+	+	CCONJ
biomedich-811	90	1	p.	p.	NOUN
biomedich-811	90	2	vivax	vivax	VERB
biomedich-811	90	3	51	51	NUM
biomedich-811	91	1	2	2	NUM
biomedich-811	91	2	96.23	96.23	NUM
biomedich-811	91	3	3.77	3.77	NUM
biomedich-811	91	4	676	676	NUM
biomedich-811	91	5	biology	biology	NOUN
biomedich-811	91	6	,	,	PUNCT
biomedich-811	91	7	medicine	medicine	NOUN
biomedich-811	91	8	,	,	PUNCT
biomedich-811	91	9	&	&	CCONJ
biomedich-811	91	10	natural	natural	ADJ
biomedich-811	91	11	product	product	NOUN
biomedich-811	91	12	chemistry	chemistry	NOUN
biomedich-811	91	13	14	14	NUM
biomedich-811	91	14	(	(	PUNCT
biomedich-811	91	15	2	2	NUM
biomedich-811	91	16	)	)	PUNCT
biomedich-811	91	17	,	,	PUNCT
biomedich-811	91	18	2025	2025	NUM
biomedich-811	91	19	:	:	PUNCT
biomedich-811	91	20	673	673	NUM
biomedich-811	91	21	-	-	SYM
biomedich-811	91	22	678	678	NUM
biomedich-811	91	23	who	who	PRON
biomedich-811	91	24	recommended	recommend	VERB
biomedich-811	91	25	microscopic	microscopic	ADJ
biomedich-811	91	26	examination	examination	NOUN
biomedich-811	91	27	as	as	ADP
biomedich-811	91	28	the	the	DET
biomedich-811	91	29	gold	gold	ADJ
biomedich-811	91	30	standard	standard	NOUN
biomedich-811	91	31	for	for	ADP
biomedich-811	91	32	malaria	malaria	NOUN
biomedich-811	91	33	diagnosis	diagnosis	NOUN
biomedich-811	91	34	.	.	PUNCT
biomedich-811	92	1	it	it	PRON
biomedich-811	92	2	provides	provide	VERB
biomedich-811	92	3	a	a	DET
biomedich-811	92	4	sensitive	sensitive	ADJ
biomedich-811	92	5	and	and	CCONJ
biomedich-811	92	6	specific	specific	ADJ
biomedich-811	92	7	diagnosis	diagnosis	NOUN
biomedich-811	92	8	of	of	ADP
biomedich-811	92	9	malaria	malaria	NOUN
biomedich-811	92	10	if	if	SCONJ
biomedich-811	92	11	performed	perform	VERB
biomedich-811	92	12	well	well	ADV
biomedich-811	92	13	.	.	PUNCT
biomedich-811	93	1	microscopic	microscopic	ADJ
biomedich-811	93	2	examination	examination	NOUN
biomedich-811	93	3	also	also	ADV
biomedich-811	93	4	allows	allow	VERB
biomedich-811	93	5	the	the	DET
biomedich-811	93	6	quantification	quantification	NOUN
biomedich-811	93	7	of	of	ADP
biomedich-811	93	8	parasites	parasite	NOUN
biomedich-811	93	9	and	and	CCONJ
biomedich-811	93	10	the	the	DET
biomedich-811	93	11	identification	identification	NOUN
biomedich-811	93	12	of	of	ADP
biomedich-811	93	13	the	the	DET
biomedich-811	93	14	infecting	infect	VERB
biomedich-811	93	15	species	specie	NOUN
biomedich-811	93	16	.	.	PUNCT
biomedich-811	94	1	however	however	ADV
biomedich-811	94	2	,	,	PUNCT
biomedich-811	94	3	it	it	PRON
biomedich-811	94	4	involves	involve	VERB
biomedich-811	94	5	relatively	relatively	ADV
biomedich-811	94	6	high	high	ADJ
biomedich-811	94	7	costs	cost	NOUN
biomedich-811	94	8	for	for	ADP
biomedich-811	94	9	training	training	NOUN
biomedich-811	94	10	and	and	CCONJ
biomedich-811	94	11	supervision	supervision	NOUN
biomedich-811	94	12	,	,	PUNCT
biomedich-811	94	13	and	and	CCONJ
biomedich-811	94	14	the	the	DET
biomedich-811	94	15	accuracy	accuracy	NOUN
biomedich-811	94	16	of	of	ADP
biomedich-811	94	17	diagnosis	diagnosis	NOUN
biomedich-811	94	18	is	be	AUX
biomedich-811	94	19	strongly	strongly	ADV
biomedich-811	94	20	dependent	dependent	ADJ
biomedich-811	94	21	on	on	ADP
biomedich-811	94	22	the	the	DET
biomedich-811	94	23	microscopic	microscopic	ADJ
biomedich-811	94	24	technicians	technician	NOUN
biomedich-811	94	25	(	(	PUNCT
biomedich-811	94	26	who	who	PRON
biomedich-811	94	27	,	,	PUNCT
biomedich-811	94	28	2024	2024	NUM
biomedich-811	94	29	)	)	PUNCT
biomedich-811	94	30	.	.	PUNCT
biomedich-811	95	1	in	in	ADP
biomedich-811	95	2	malaria	malaria	NOUN
biomedich-811	95	3	-	-	PUNCT
biomedich-811	95	4	endemic	endemic	ADJ
biomedich-811	95	5	areas	area	NOUN
biomedich-811	95	6	,	,	PUNCT
biomedich-811	95	7	malaria	malaria	NOUN
biomedich-811	95	8	should	should	AUX
biomedich-811	95	9	be	be	AUX
biomedich-811	95	10	suspected	suspect	VERB
biomedich-811	95	11	in	in	ADP
biomedich-811	95	12	any	any	DET
biomedich-811	95	13	patient	patient	NOUN
biomedich-811	95	14	with	with	ADP
biomedich-811	95	15	a	a	DET
biomedich-811	95	16	history	history	NOUN
biomedich-811	95	17	of	of	ADP
biomedich-811	95	18	fever	fever	NOUN
biomedich-811	95	19	and	and	CCONJ
biomedich-811	95	20	no	no	DET
biomedich-811	95	21	other	other	ADJ
biomedich-811	95	22	obvious	obvious	ADJ
biomedich-811	95	23	cause	cause	NOUN
biomedich-811	95	24	.	.	PUNCT
biomedich-811	96	1	although	although	SCONJ
biomedich-811	96	2	molecular	molecular	ADJ
biomedich-811	96	3	methods	method	NOUN
biomedich-811	96	4	such	such	ADJ
biomedich-811	96	5	as	as	ADP
biomedich-811	96	6	pcr	pcr	PROPN
biomedich-811	96	7	have	have	VERB
biomedich-811	96	8	higher	high	ADJ
biomedich-811	96	9	sensitivity	sensitivity	NOUN
biomedich-811	96	10	and	and	CCONJ
biomedich-811	96	11	specificity	specificity	NOUN
biomedich-811	96	12	to	to	PART
biomedich-811	96	13	diagnose	diagnose	VERB
biomedich-811	96	14	malaria	malaria	NOUN
biomedich-811	96	15	,	,	PUNCT
biomedich-811	96	16	the	the	DET
biomedich-811	96	17	microscopic	microscopic	ADJ
biomedich-811	96	18	examination	examination	NOUN
biomedich-811	96	19	is	be	AUX
biomedich-811	96	20	still	still	ADV
biomedich-811	96	21	the	the	DET
biomedich-811	96	22	gold	gold	ADJ
biomedich-811	96	23	standard	standard	NOUN
biomedich-811	96	24	because	because	SCONJ
biomedich-811	96	25	it	it	PRON
biomedich-811	96	26	is	be	AUX
biomedich-811	96	27	simpler	simple	ADJ
biomedich-811	96	28	and	and	CCONJ
biomedich-811	96	29	does	do	AUX
biomedich-811	96	30	not	not	PART
biomedich-811	96	31	need	need	VERB
biomedich-811	96	32	advanced	advanced	ADJ
biomedich-811	96	33	resources	resource	NOUN
biomedich-811	96	34	and	and	CCONJ
biomedich-811	96	35	highcost	highcost	NOUN
biomedich-811	96	36	equipment	equipment	NOUN
biomedich-811	96	37	to	to	PART
biomedich-811	96	38	perform	perform	VERB
biomedich-811	96	39	the	the	DET
biomedich-811	96	40	test	test	NOUN
biomedich-811	96	41	compared	compare	VERB
biomedich-811	96	42	to	to	ADP
biomedich-811	96	43	the	the	DET
biomedich-811	96	44	molecular	molecular	ADJ
biomedich-811	96	45	method	method	NOUN
biomedich-811	96	46	.	.	PUNCT
biomedich-811	97	1	furthermore	furthermore	ADV
biomedich-811	97	2	,	,	PUNCT
biomedich-811	97	3	the	the	PRON
biomedich-811	97	4	who	who	PRON
biomedich-811	97	5	recommended	recommend	VERB
biomedich-811	97	6	that	that	SCONJ
biomedich-811	97	7	,	,	PUNCT
biomedich-811	97	8	at	at	ADP
biomedich-811	97	9	present	present	ADJ
biomedich-811	97	10	,	,	PUNCT
biomedich-811	97	11	molecular	molecular	ADJ
biomedich-811	97	12	diagnostic	diagnostic	ADJ
biomedich-811	97	13	tools	tool	NOUN
biomedich-811	97	14	based	base	VERB
biomedich-811	97	15	on	on	ADP
biomedich-811	97	16	nucleic	nucleic	ADJ
biomedich-811	97	17	acid	acid	NOUN
biomedich-811	97	18	amplification	amplification	NOUN
biomedich-811	97	19	techniques	technique	NOUN
biomedich-811	97	20	,	,	PUNCT
biomedich-811	97	21	such	such	ADJ
biomedich-811	97	22	as	as	ADP
biomedich-811	97	23	loopmediated	loopmediate	VERB
biomedich-811	97	24	isothermal	isothermal	ADJ
biomedich-811	97	25	amplification	amplification	NOUN
biomedich-811	97	26	or	or	CCONJ
biomedich-811	97	27	pcr	pcr	NOUN
biomedich-811	97	28	,	,	PUNCT
biomedich-811	97	29	do	do	AUX
biomedich-811	97	30	not	not	PART
biomedich-811	97	31	have	have	VERB
biomedich-811	97	32	a	a	DET
biomedich-811	97	33	role	role	NOUN
biomedich-811	97	34	in	in	ADP
biomedich-811	97	35	the	the	DET
biomedich-811	97	36	clinical	clinical	ADJ
biomedich-811	97	37	management	management	NOUN
biomedich-811	97	38	of	of	ADP
biomedich-811	97	39	malaria	malaria	NOUN
biomedich-811	97	40	(	(	PUNCT
biomedich-811	97	41	who	who	PRON
biomedich-811	97	42	,	,	PUNCT
biomedich-811	97	43	2024	2024	NUM
biomedich-811	97	44	)	)	PUNCT
biomedich-811	97	45	.	.	PUNCT
biomedich-811	98	1	i̇n	i̇n	NOUN
biomedich-811	98	2	this	this	DET
biomedich-811	98	3	study	study	NOUN
biomedich-811	98	4	,	,	PUNCT
biomedich-811	98	5	we	we	PRON
biomedich-811	98	6	performed	perform	VERB
biomedich-811	98	7	pcr	pcr	PROPN
biomedich-811	98	8	to	to	PART
biomedich-811	98	9	identify	identify	VERB
biomedich-811	98	10	the	the	DET
biomedich-811	98	11	molecular	molecular	ADJ
biomedich-811	98	12	marker	marker	NOUN
biomedich-811	98	13	of	of	ADP
biomedich-811	98	14	antimalarial	antimalarial	ADJ
biomedich-811	98	15	resistance	resistance	NOUN
biomedich-811	98	16	specifically	specifically	ADV
biomedich-811	98	17	to	to	ADP
biomedich-811	98	18	the	the	DET
biomedich-811	98	19	p.	p.	NOUN
biomedich-811	98	20	falciparum	falciparum	PROPN
biomedich-811	98	21	multidrug	multidrug	PROPN
biomedich-811	98	22	resistance-1	resistance-1	PROPN
biomedich-811	98	23	(	(	PUNCT
biomedich-811	98	24	pfmdr1	pfmdr1	NOUN
biomedich-811	98	25	)	)	PUNCT
biomedich-811	98	26	gene	gene	NOUN
biomedich-811	98	27	.	.	PUNCT
biomedich-811	99	1	the	the	DET
biomedich-811	99	2	pcr	pcr	ADJ
biomedich-811	99	3	amplification	amplification	NOUN
biomedich-811	99	4	was	be	AUX
biomedich-811	99	5	conducted	conduct	VERB
biomedich-811	99	6	using	use	VERB
biomedich-811	99	7	specific	specific	ADJ
biomedich-811	99	8	primer	primer	NOUN
biomedich-811	99	9	pairs	pair	NOUN
biomedich-811	99	10	to	to	PART
biomedich-811	99	11	detect	detect	VERB
biomedich-811	99	12	the	the	DET
biomedich-811	99	13	pfmdr1	pfmdr1	PROPN
biomedich-811	99	14	gene	gene	NOUN
biomedich-811	99	15	,	,	PUNCT
biomedich-811	99	16	i.e.	i.e.	X
biomedich-811	99	17	,	,	PUNCT
biomedich-811	99	18	pfmdr1	pfmdr1	PROPN
biomedich-811	99	19	-	-	PUNCT
biomedich-811	99	20	a	a	PROPN
biomedich-811	99	21	and	and	CCONJ
biomedich-811	99	22	pfmdr1	pfmdr1	PROPN
biomedich-811	99	23	-	-	PUNCT
biomedich-811	99	24	b	b	PROPN
biomedich-811	99	25	(	(	PUNCT
biomedich-811	99	26	adamu	adamu	PROPN
biomedich-811	99	27	et	et	PROPN
biomedich-811	99	28	al	al	PROPN
biomedich-811	99	29	.	.	PROPN
biomedich-811	99	30	,	,	PUNCT
biomedich-811	99	31	2020	2020	NUM
biomedich-811	99	32	)	)	PUNCT
biomedich-811	99	33	.	.	PUNCT
biomedich-811	100	1	both	both	DET
biomedich-811	100	2	amplification	amplification	NOUN
biomedich-811	100	3	methods	method	NOUN
biomedich-811	100	4	are	be	AUX
biomedich-811	100	5	nested	nest	VERB
biomedich-811	100	6	pcr	pcr	PROPN
biomedich-811	100	7	,	,	PUNCT
biomedich-811	100	8	i.e.	i.e.	X
biomedich-811	100	9	,	,	PUNCT
biomedich-811	100	10	a	a	DET
biomedich-811	100	11	modification	modification	NOUN
biomedich-811	100	12	of	of	ADP
biomedich-811	100	13	pcr	pcr	NOUN
biomedich-811	100	14	that	that	PRON
biomedich-811	100	15	uses	use	VERB
biomedich-811	100	16	two	two	NUM
biomedich-811	100	17	sets	set	NOUN
biomedich-811	100	18	and	and	CCONJ
biomedich-811	100	19	two	two	NUM
biomedich-811	100	20	successive	successive	ADJ
biomedich-811	100	21	pcr	pcr	ADJ
biomedich-811	100	22	reactions	reaction	NOUN
biomedich-811	100	23	,	,	PUNCT
biomedich-811	100	24	the	the	DET
biomedich-811	100	25	first	first	ADJ
biomedich-811	100	26	set	set	NOUN
biomedich-811	100	27	of	of	ADP
biomedich-811	100	28	primer	primer	NOUN
biomedich-811	100	29	pairs	pair	NOUN
biomedich-811	100	30	is	be	AUX
biomedich-811	100	31	designed	design	VERB
biomedich-811	100	32	to	to	PART
biomedich-811	100	33	anneal	anneal	VERB
biomedich-811	100	34	upstream	upstream	ADV
biomedich-811	100	35	from	from	ADP
biomedich-811	100	36	the	the	DET
biomedich-811	100	37	second	second	ADJ
biomedich-811	100	38	set	set	NOUN
biomedich-811	100	39	of	of	ADP
biomedich-811	100	40	primer	primer	NOUN
biomedich-811	100	41	pairs	pair	NOUN
biomedich-811	100	42	,	,	PUNCT
biomedich-811	100	43	so	so	SCONJ
biomedich-811	100	44	the	the	DET
biomedich-811	100	45	product	product	NOUN
biomedich-811	100	46	of	of	ADP
biomedich-811	100	47	the	the	DET
biomedich-811	100	48	first	first	ADJ
biomedich-811	100	49	pcr	pcr	NOUN
biomedich-811	100	50	is	be	AUX
biomedich-811	100	51	used	use	VERB
biomedich-811	100	52	as	as	ADP
biomedich-811	100	53	a	a	DET
biomedich-811	100	54	template	template	NOUN
biomedich-811	100	55	for	for	ADP
biomedich-811	100	56	the	the	DET
biomedich-811	100	57	second	second	ADJ
biomedich-811	100	58	pcr	pcr	NOUN
biomedich-811	100	59	.	.	PUNCT
biomedich-811	101	1	nested	nested	ADJ
biomedich-811	101	2	pcr	pcr	PROPN
biomedich-811	101	3	was	be	AUX
biomedich-811	101	4	designed	design	VERB
biomedich-811	101	5	to	to	PART
biomedich-811	101	6	improve	improve	VERB
biomedich-811	101	7	sensitivity	sensitivity	NOUN
biomedich-811	101	8	and	and	CCONJ
biomedich-811	101	9	specificity	specificity	NOUN
biomedich-811	101	10	because	because	SCONJ
biomedich-811	101	11	it	it	PRON
biomedich-811	101	12	can	can	AUX
biomedich-811	101	13	reduce	reduce	VERB
biomedich-811	101	14	the	the	DET
biomedich-811	101	15	amount	amount	NOUN
biomedich-811	101	16	of	of	ADP
biomedich-811	101	17	nonspecific	nonspecific	ADJ
biomedich-811	101	18	binding	binding	NOUN
biomedich-811	101	19	,	,	PUNCT
biomedich-811	101	20	and	and	CCONJ
biomedich-811	101	21	the	the	DET
biomedich-811	101	22	technique	technique	NOUN
biomedich-811	101	23	is	be	AUX
biomedich-811	101	24	useful	useful	ADJ
biomedich-811	101	25	on	on	ADP
biomedich-811	101	26	suboptimal	suboptimal	ADJ
biomedich-811	101	27	nucleic	nucleic	ADJ
biomedich-811	101	28	acid	acid	NOUN
biomedich-811	101	29	samples	sample	NOUN
biomedich-811	101	30	,	,	PUNCT
biomedich-811	101	31	such	such	ADJ
biomedich-811	101	32	as	as	ADP
biomedich-811	101	33	samples	sample	NOUN
biomedich-811	101	34	extracted	extract	VERB
biomedich-811	101	35	from	from	ADP
biomedich-811	101	36	formalin	formalin	NOUN
biomedich-811	101	37	-	-	PUNCT
biomedich-811	101	38	fixed	fix	VERB
biomedich-811	101	39	or	or	CCONJ
biomedich-811	101	40	paraffin	paraffin	NOUN
biomedich-811	101	41	-	-	PUNCT
biomedich-811	101	42	embedded	embed	VERB
biomedich-811	101	43	tissue	tissue	NOUN
biomedich-811	101	44	.	.	PUNCT
biomedich-811	102	1	however	however	ADV
biomedich-811	102	2	,	,	PUNCT
biomedich-811	102	3	this	this	DET
biomedich-811	102	4	technique	technique	NOUN
biomedich-811	102	5	could	could	AUX
biomedich-811	102	6	increase	increase	VERB
biomedich-811	102	7	potential	potential	ADJ
biomedich-811	102	8	contamination	contamination	NOUN
biomedich-811	102	9	due	due	ADP
biomedich-811	102	10	to	to	ADP
biomedich-811	102	11	additional	additional	ADJ
biomedich-811	102	12	manipulation	manipulation	NOUN
biomedich-811	102	13	of	of	ADP
biomedich-811	102	14	amplicon	amplicon	NOUN
biomedich-811	102	15	products	product	NOUN
biomedich-811	102	16	.	.	PUNCT
biomedich-811	103	1	but	but	CCONJ
biomedich-811	103	2	,	,	PUNCT
biomedich-811	103	3	it	it	PRON
biomedich-811	103	4	can	can	AUX
biomedich-811	103	5	be	be	AUX
biomedich-811	103	6	minimized	minimize	VERB
biomedich-811	103	7	by	by	ADP
biomedich-811	103	8	physically	physically	ADV
biomedich-811	103	9	separating	separate	VERB
biomedich-811	103	10	different	different	ADJ
biomedich-811	103	11	parts	part	NOUN
biomedich-811	103	12	of	of	ADP
biomedich-811	103	13	the	the	DET
biomedich-811	103	14	process	process	NOUN
biomedich-811	103	15	(	(	PUNCT
biomedich-811	103	16	green	green	PROPN
biomedich-811	103	17	&	&	CCONJ
biomedich-811	103	18	sambrook	sambrook	PROPN
biomedich-811	103	19	,	,	PUNCT
biomedich-811	103	20	2019	2019	NUM
biomedich-811	103	21	)	)	PUNCT
biomedich-811	103	22	.	.	PUNCT
biomedich-811	104	1	amplification	amplification	NOUN
biomedich-811	104	2	using	use	VERB
biomedich-811	104	3	pfmdr1	pfmdr1	PROPN
biomedich-811	104	4	-	-	PUNCT
biomedich-811	104	5	a	a	DET
biomedich-811	104	6	specific	specific	ADJ
biomedich-811	104	7	primer	primer	NOUN
biomedich-811	104	8	resulted	result	VERB
biomedich-811	104	9	in	in	ADP
biomedich-811	104	10	a	a	DET
biomedich-811	104	11	single	single	ADJ
biomedich-811	104	12	band	band	NOUN
biomedich-811	104	13	of	of	ADP
biomedich-811	104	14	approximately	approximately	ADV
biomedich-811	104	15	864	864	NUM
biomedich-811	104	16	bp	bp	PROPN
biomedich-811	104	17	(	(	PUNCT
biomedich-811	104	18	figure	figure	NOUN
biomedich-811	104	19	1	1	NUM
biomedich-811	104	20	)	)	PUNCT
biomedich-811	104	21	.	.	PUNCT
biomedich-811	105	1	the	the	DET
biomedich-811	105	2	result	result	NOUN
biomedich-811	105	3	is	be	AUX
biomedich-811	105	4	similar	similar	ADJ
biomedich-811	105	5	to	to	ADP
biomedich-811	105	6	the	the	DET
biomedich-811	105	7	previous	previous	ADJ
biomedich-811	105	8	study	study	NOUN
biomedich-811	105	9	(	(	PUNCT
biomedich-811	105	10	adamu	adamu	PROPN
biomedich-811	105	11	et	et	PROPN
biomedich-811	105	12	al	al	PROPN
biomedich-811	105	13	.	.	PROPN
biomedich-811	105	14	,	,	PUNCT
biomedich-811	105	15	2020	2020	NUM
biomedich-811	105	16	)	)	PUNCT
biomedich-811	105	17	.	.	PUNCT
biomedich-811	106	1	we	we	PRON
biomedich-811	106	2	used	use	VERB
biomedich-811	106	3	identical	identical	ADJ
biomedich-811	106	4	pcr	pcr	ADJ
biomedich-811	106	5	primer	primer	NOUN
biomedich-811	106	6	sequences	sequence	NOUN
biomedich-811	106	7	and	and	CCONJ
biomedich-811	106	8	cycles	cycle	NOUN
biomedich-811	106	9	.	.	PUNCT
biomedich-811	107	1	optimization	optimization	NOUN
biomedich-811	107	2	of	of	ADP
biomedich-811	107	3	the	the	DET
biomedich-811	107	4	pcr	pcr	NOUN
biomedich-811	107	5	setting	setting	NOUN
biomedich-811	107	6	was	be	AUX
biomedich-811	107	7	done	do	VERB
biomedich-811	107	8	based	base	VERB
biomedich-811	107	9	on	on	ADP
biomedich-811	107	10	an	an	DET
biomedich-811	107	11	earlier	early	ADJ
biomedich-811	107	12	study	study	NOUN
biomedich-811	107	13	,	,	PUNCT
biomedich-811	107	14	and	and	CCONJ
biomedich-811	107	15	it	it	PRON
biomedich-811	107	16	yielded	yield	VERB
biomedich-811	107	17	a	a	DET
biomedich-811	107	18	single	single	ADJ
biomedich-811	107	19	band	band	NOUN
biomedich-811	107	20	,	,	PUNCT
biomedich-811	107	21	as	as	SCONJ
biomedich-811	107	22	expected	expect	VERB
biomedich-811	107	23	.	.	PUNCT
biomedich-811	108	1	i̇n	i̇n	PROPN
biomedich-811	108	2	contrast	contrast	NOUN
biomedich-811	108	3	,	,	PUNCT
biomedich-811	108	4	amplification	amplification	NOUN
biomedich-811	108	5	using	use	VERB
biomedich-811	108	6	pfmdr1	pfmdr1	PROPN
biomedich-811	108	7	-	-	PUNCT
biomedich-811	108	8	b	b	PROPN
biomedich-811	108	9	specific	specific	ADJ
biomedich-811	108	10	primer	primer	NOUN
biomedich-811	108	11	was	be	AUX
biomedich-811	108	12	performed	perform	VERB
biomedich-811	108	13	with	with	ADP
biomedich-811	108	14	several	several	ADJ
biomedich-811	108	15	pcr	pcr	ADJ
biomedich-811	108	16	cycles	cycle	NOUN
biomedich-811	108	17	optimization	optimization	NOUN
biomedich-811	108	18	,	,	PUNCT
biomedich-811	108	19	especially	especially	ADV
biomedich-811	108	20	at	at	ADP
biomedich-811	108	21	the	the	DET
biomedich-811	108	22	annealing	anneal	VERB
biomedich-811	108	23	step	step	NOUN
biomedich-811	108	24	for	for	ADP
biomedich-811	108	25	both	both	DET
biomedich-811	108	26	nested-1	nested-1	NUM
biomedich-811	108	27	and	and	CCONJ
biomedich-811	108	28	nested-2	nested-2	NUM
biomedich-811	108	29	pcr	pcr	NOUN
biomedich-811	108	30	.	.	PUNCT
biomedich-811	109	1	the	the	DET
biomedich-811	109	2	first	first	ADJ
biomedich-811	109	3	optimization	optimization	NOUN
biomedich-811	109	4	used	use	VERB
biomedich-811	109	5	55oc	55oc	NOUN
biomedich-811	109	6	for	for	ADP
biomedich-811	109	7	nested-1	nested-1	NUM
biomedich-811	109	8	and	and	CCONJ
biomedich-811	109	9	60oc	60oc	ADJ
biomedich-811	109	10	for	for	ADP
biomedich-811	109	11	nested-2	nested-2	NOUN
biomedich-811	109	12	,	,	PUNCT
biomedich-811	109	13	yielding	yield	VERB
biomedich-811	109	14	double	double	ADJ
biomedich-811	109	15	bands	band	NOUN
biomedich-811	109	16	;	;	PUNCT
biomedich-811	109	17	the	the	DET
biomedich-811	109	18	second	second	ADJ
biomedich-811	109	19	optimization	optimization	NOUN
biomedich-811	109	20	used	use	VERB
biomedich-811	109	21	57oc	57oc	NOUN
biomedich-811	109	22	for	for	ADP
biomedich-811	109	23	nested-1	nested-1	NUM
biomedich-811	109	24	and	and	CCONJ
biomedich-811	109	25	62oc	62oc	NOUN
biomedich-811	109	26	for	for	ADP
biomedich-811	109	27	nested-2	nested-2	NUM
biomedich-811	109	28	(	(	PUNCT
biomedich-811	109	29	figure	figure	NOUN
biomedich-811	109	30	2	2	NUM
biomedich-811	109	31	)	)	PUNCT
biomedich-811	109	32	.	.	PUNCT
biomedich-811	110	1	the	the	DET
biomedich-811	110	2	second	second	ADJ
biomedich-811	110	3	optimization	optimization	NOUN
biomedich-811	110	4	resulted	result	VERB
biomedich-811	110	5	in	in	ADP
biomedich-811	110	6	a	a	DET
biomedich-811	110	7	single	single	ADJ
biomedich-811	110	8	band	band	NOUN
biomedich-811	110	9	of	of	ADP
biomedich-811	110	10	approximately	approximately	ADV
biomedich-811	110	11	534	534	NUM
biomedich-811	110	12	bp	bp	NOUN
biomedich-811	110	13	.	.	PUNCT
biomedich-811	111	1	pcr	pcr	ADJ
biomedich-811	111	2	optimization	optimization	NOUN
biomedich-811	111	3	is	be	AUX
biomedich-811	111	4	essential	essential	ADJ
biomedich-811	111	5	when	when	SCONJ
biomedich-811	111	6	conducting	conduct	VERB
biomedich-811	111	7	a	a	DET
biomedich-811	111	8	certain	certain	ADJ
biomedich-811	111	9	pcr	pcr	NOUN
biomedich-811	111	10	for	for	ADP
biomedich-811	111	11	the	the	DET
biomedich-811	111	12	first	first	ADJ
biomedich-811	111	13	time	time	NOUN
biomedich-811	111	14	in	in	ADP
biomedich-811	111	15	our	our	PRON
biomedich-811	111	16	laboratory	laboratory	NOUN
biomedich-811	111	17	.	.	PUNCT
biomedich-811	112	1	although	although	SCONJ
biomedich-811	112	2	the	the	DET
biomedich-811	112	3	pcr	pcr	NOUN
biomedich-811	112	4	has	have	AUX
biomedich-811	112	5	been	be	AUX
biomedich-811	112	6	done	do	VERB
biomedich-811	112	7	with	with	ADP
biomedich-811	112	8	the	the	DET
biomedich-811	112	9	same	same	ADJ
biomedich-811	112	10	setting	setting	NOUN
biomedich-811	112	11	in	in	ADP
biomedich-811	112	12	previous	previous	ADJ
biomedich-811	112	13	studies	study	NOUN
biomedich-811	112	14	,	,	PUNCT
biomedich-811	112	15	however	however	ADV
biomedich-811	112	16	,	,	PUNCT
biomedich-811	112	17	the	the	DET
biomedich-811	112	18	optimum	optimum	ADJ
biomedich-811	112	19	conditions	condition	NOUN
biomedich-811	112	20	in	in	ADP
biomedich-811	112	21	our	our	PRON
biomedich-811	112	22	laboratory	laboratory	NOUN
biomedich-811	112	23	could	could	AUX
biomedich-811	112	24	be	be	AUX
biomedich-811	112	25	different	different	ADJ
biomedich-811	112	26	due	due	ADP
biomedich-811	112	27	to	to	ADP
biomedich-811	112	28	a	a	DET
biomedich-811	112	29	different	different	ADJ
biomedich-811	112	30	pcr	pcr	ADJ
biomedich-811	112	31	machine	machine	NOUN
biomedich-811	112	32	,	,	PUNCT
biomedich-811	112	33	kits	kit	NOUN
biomedich-811	112	34	or	or	CCONJ
biomedich-811	112	35	reagents	reagent	NOUN
biomedich-811	112	36	used	use	VERB
biomedich-811	112	37	,	,	PUNCT
biomedich-811	112	38	the	the	DET
biomedich-811	112	39	company	company	NOUN
biomedich-811	112	40	supplier	supplier	NOUN
biomedich-811	112	41	,	,	PUNCT
biomedich-811	112	42	and	and	CCONJ
biomedich-811	112	43	other	other	ADJ
biomedich-811	112	44	laboratory	laboratory	NOUN
biomedich-811	112	45	conditions	condition	NOUN
biomedich-811	112	46	.	.	PUNCT
biomedich-811	113	1	as	as	ADP
biomedich-811	113	2	a	a	DET
biomedich-811	113	3	result	result	NOUN
biomedich-811	113	4	of	of	ADP
biomedich-811	113	5	the	the	DET
biomedich-811	113	6	study	study	NOUN
biomedich-811	113	7	,	,	PUNCT
biomedich-811	113	8	our	our	PRON
biomedich-811	113	9	pcr	pcr	ADJ
biomedich-811	113	10	settings	setting	NOUN
biomedich-811	113	11	are	be	AUX
biomedich-811	113	12	slightly	slightly	ADV
biomedich-811	113	13	different	different	ADJ
biomedich-811	113	14	from	from	ADP
biomedich-811	113	15	those	those	PRON
biomedich-811	113	16	of	of	ADP
biomedich-811	113	17	the	the	DET
biomedich-811	113	18	previous	previous	ADJ
biomedich-811	113	19	study	study	NOUN
biomedich-811	113	20	,	,	PUNCT
biomedich-811	113	21	especially	especially	ADV
biomedich-811	113	22	in	in	ADP
biomedich-811	113	23	terms	term	NOUN
biomedich-811	113	24	of	of	ADP
biomedich-811	113	25	the	the	DET
biomedich-811	113	26	annealing	anneal	VERB
biomedich-811	113	27	temperature	temperature	NOUN
biomedich-811	113	28	for	for	ADP
biomedich-811	113	29	the	the	DET
biomedich-811	113	30	pfmdr1	pfmdr1	PROPN
biomedich-811	113	31	-	-	PUNCT
biomedich-811	113	32	b	b	PROPN
biomedich-811	113	33	gene	gene	NOUN
biomedich-811	113	34	.	.	PUNCT
biomedich-811	114	1	figure	figure	NOUN
biomedich-811	114	2	1	1	NUM
biomedich-811	114	3	.	.	PUNCT
biomedich-811	115	1	the	the	DET
biomedich-811	115	2	amplification	amplification	NOUN
biomedich-811	115	3	results	result	VERB
biomedich-811	115	4	using	use	VERB
biomedich-811	115	5	pfmdr1	pfmdr1	PROPN
biomedich-811	115	6	-	-	PUNCT
biomedich-811	115	7	a	a	DET
biomedich-811	115	8	primer	primer	NOUN
biomedich-811	115	9	.	.	PUNCT
biomedich-811	116	1	the	the	DET
biomedich-811	116	2	target	target	NOUN
biomedich-811	116	3	amplicon	amplicon	NOUN
biomedich-811	116	4	was	be	AUX
biomedich-811	116	5	864	864	NUM
biomedich-811	116	6	bp	bp	PROPN
biomedich-811	116	7	and	and	CCONJ
biomedich-811	116	8	observed	observe	VERB
biomedich-811	116	9	at	at	ADP
biomedich-811	116	10	lines	line	NOUN
biomedich-811	116	11	1	1	NUM
biomedich-811	116	12	and	and	CCONJ
biomedich-811	116	13	2	2	NUM
biomedich-811	116	14	.	.	X
biomedich-811	116	15	line	line	NOUN
biomedich-811	116	16	1	1	NUM
biomedich-811	116	17	:	:	PUNCT
biomedich-811	116	18	patient	patient	ADJ
biomedich-811	116	19	1	1	NUM
biomedich-811	116	20	;	;	PUNCT
biomedich-811	116	21	line	line	NOUN
biomedich-811	116	22	2	2	NUM
biomedich-811	116	23	:	:	PUNCT
biomedich-811	116	24	patient	patient	NOUN
biomedich-811	116	25	2	2	NUM
biomedich-811	116	26	;	;	PUNCT
biomedich-811	116	27	m	m	NUM
biomedich-811	116	28	;	;	PUNCT
biomedich-811	116	29	dna	dna	PROPN
biomedich-811	116	30	marker	marker	NOUN
biomedich-811	116	31	;	;	PUNCT
biomedich-811	116	32	c-	c-	NUM
biomedich-811	116	33	:	:	PUNCT
biomedich-811	116	34	negative	negative	ADJ
biomedich-811	116	35	control	control	NOUN
biomedich-811	116	36	.	.	PUNCT
biomedich-811	117	1	the	the	DET
biomedich-811	117	2	pfmdr1	pfmdr1	PROPN
biomedich-811	117	3	gene	gene	PROPN
biomedich-811	117	4	is	be	AUX
biomedich-811	117	5	central	central	ADJ
biomedich-811	117	6	in	in	ADP
biomedich-811	117	7	p.	p.	PROPN
biomedich-811	117	8	falciparum	falciparum	NOUN
biomedich-811	118	1	artemisinin	artemisinin	NOUN
biomedich-811	118	2	-	-	PUNCT
biomedich-811	118	3	based	base	VERB
biomedich-811	118	4	combination	combination	NOUN
biomedich-811	118	5	therapy	therapy	NOUN
biomedich-811	118	6	(	(	PUNCT
biomedich-811	118	7	act	act	PROPN
biomedich-811	118	8	)	)	PUNCT
biomedich-811	118	9	resistance	resistance	NOUN
biomedich-811	118	10	but	but	CCONJ
biomedich-811	118	11	is	be	AUX
biomedich-811	118	12	not	not	PART
biomedich-811	118	13	associated	associate	VERB
biomedich-811	118	14	with	with	ADP
biomedich-811	118	15	resistance	resistance	NOUN
biomedich-811	118	16	to	to	ADP
biomedich-811	118	17	single	single	ADJ
biomedich-811	118	18	artemisinin	artemisinin	NOUN
biomedich-811	118	19	(	(	PUNCT
biomedich-811	118	20	veiga	veiga	PROPN
biomedich-811	118	21	et	et	PROPN
biomedich-811	118	22	al	al	PROPN
biomedich-811	118	23	.	.	PROPN
biomedich-811	118	24	,	,	PUNCT
biomedich-811	118	25	2016	2016	NUM
biomedich-811	118	26	)	)	PUNCT
biomedich-811	118	27	.	.	PUNCT
biomedich-811	119	1	it	it	PRON
biomedich-811	119	2	has	have	AUX
biomedich-811	119	3	been	be	AUX
biomedich-811	119	4	associated	associate	VERB
biomedich-811	119	5	with	with	ADP
biomedich-811	119	6	resistance	resistance	NOUN
biomedich-811	119	7	to	to	ADP
biomedich-811	119	8	drugs	drug	NOUN
biomedich-811	119	9	such	such	ADJ
biomedich-811	119	10	as	as	ADP
biomedich-811	119	11	mefloquine	mefloquine	NOUN
biomedich-811	119	12	(	(	PUNCT
biomedich-811	119	13	mfq	mfq	NOUN
biomedich-811	119	14	)	)	PUNCT
biomedich-811	119	15	,	,	PUNCT
biomedich-811	119	16	halofantrine	halofantrine	NOUN
biomedich-811	119	17	(	(	PUNCT
biomedich-811	119	18	hf	hf	NOUN
biomedich-811	119	19	)	)	PUNCT
biomedich-811	119	20	,	,	PUNCT
biomedich-811	119	21	and	and	CCONJ
biomedich-811	119	22	lumefantrine	lumefantrine	ADJ
biomedich-811	119	23	(	(	PUNCT
biomedich-811	119	24	lmf	lmf	PROPN
biomedich-811	119	25	)	)	PUNCT
biomedich-811	119	26	(	(	PUNCT
biomedich-811	119	27	price	price	NOUN
biomedich-811	119	28	et	et	PROPN
biomedich-811	119	29	al	al	PROPN
biomedich-811	119	30	.	.	PROPN
biomedich-811	119	31	,	,	PUNCT
biomedich-811	119	32	2004)(sisowath	2004)(sisowath	NUM
biomedich-811	119	33	et	et	PROPN
biomedich-811	119	34	al	al	PROPN
biomedich-811	119	35	.	.	PROPN
biomedich-811	119	36	,	,	PUNCT
biomedich-811	119	37	2007)(mungthin	2007)(mungthin	NUM
biomedich-811	119	38	et	et	NOUN
biomedich-811	119	39	al	al	PROPN
biomedich-811	119	40	.	.	PROPN
biomedich-811	119	41	,	,	PUNCT
biomedich-811	119	42	2010	2010	NUM
biomedich-811	119	43	)	)	PUNCT
biomedich-811	119	44	.	.	PUNCT
biomedich-811	120	1	the	the	DET
biomedich-811	120	2	gene	gene	NOUN
biomedich-811	120	3	encodes	encode	VERB
biomedich-811	120	4	the	the	DET
biomedich-811	120	5	protein	protein	NOUN
biomedich-811	120	6	that	that	PRON
biomedich-811	120	7	can	can	AUX
biomedich-811	120	8	transport	transport	VERB
biomedich-811	120	9	drugs	drug	NOUN
biomedich-811	120	10	into	into	ADP
biomedich-811	120	11	the	the	DET
biomedich-811	120	12	digestive	digestive	ADJ
biomedich-811	120	13	vacuole	vacuole	NOUN
biomedich-811	120	14	(	(	PUNCT
biomedich-811	120	15	dv	dv	PROPN
biomedich-811	120	16	)	)	PUNCT
biomedich-811	120	17	membrane	membrane	NOUN
biomedich-811	120	18	.	.	PUNCT
biomedich-811	121	1	in	in	ADP
biomedich-811	121	2	contrast	contrast	NOUN
biomedich-811	121	3	,	,	PUNCT
biomedich-811	121	4	the	the	DET
biomedich-811	121	5	drugs	drug	NOUN
biomedich-811	121	6	'	'	PART
biomedich-811	121	7	main	main	ADJ
biomedich-811	121	8	target	target	NOUN
biomedich-811	121	9	is	be	AUX
biomedich-811	121	10	in	in	ADP
biomedich-811	121	11	the	the	DET
biomedich-811	121	12	cytosol	cytosol	NOUN
biomedich-811	121	13	,	,	PUNCT
biomedich-811	121	14	making	make	VERB
biomedich-811	121	15	them	they	PRON
biomedich-811	121	16	less	less	ADV
biomedich-811	121	17	effective	effective	ADJ
biomedich-811	121	18	once	once	ADV
biomedich-811	121	19	transported	transport	VERB
biomedich-811	121	20	by	by	ADP
biomedich-811	121	21	pfmdr1	pfmdr1	PROPN
biomedich-811	121	22	into	into	ADP
biomedich-811	121	23	the	the	DET
biomedich-811	121	24	dv	dv	PROPN
biomedich-811	121	25	(	(	PUNCT
biomedich-811	121	26	si	si	PROPN
biomedich-811	121	27	et	et	PROPN
biomedich-811	121	28	al	al	PROPN
biomedich-811	121	29	.	.	PROPN
biomedich-811	121	30	,	,	PUNCT
biomedich-811	121	31	2023)(wurtz	2023)(wurtz	NUM
biomedich-811	121	32	et	et	NOUN
biomedich-811	121	33	al	al	PROPN
biomedich-811	121	34	.	.	PROPN
biomedich-811	121	35	,	,	PUNCT
biomedich-811	121	36	2014	2014	NUM
biomedich-811	121	37	)	)	PUNCT
biomedich-811	121	38	.	.	PUNCT
biomedich-811	122	1	the	the	DET
biomedich-811	122	2	copy	copy	NOUN
biomedich-811	122	3	number	number	NOUN
biomedich-811	122	4	of	of	ADP
biomedich-811	122	5	pfmdr1	pfmdr1	PROPN
biomedich-811	122	6	significantly	significantly	ADV
biomedich-811	122	7	affects	affect	VERB
biomedich-811	122	8	parasite	parasite	ADJ
biomedich-811	122	9	sensitivity	sensitivity	NOUN
biomedich-811	122	10	to	to	ADP
biomedich-811	122	11	those	those	DET
biomedich-811	122	12	act	act	NOUN
biomedich-811	122	13	drugs	drug	NOUN
biomedich-811	122	14	.	.	PUNCT
biomedich-811	123	1	studies	study	NOUN
biomedich-811	123	2	reported	report	VERB
biomedich-811	123	3	that	that	SCONJ
biomedich-811	123	4	the	the	DET
biomedich-811	123	5	pfmdr1	pfmdr1	PROPN
biomedich-811	123	6	copy	copy	NOUN
biomedich-811	123	7	number	number	NOUN
biomedich-811	123	8	is	be	AUX
biomedich-811	123	9	prevalent	prevalent	ADJ
biomedich-811	123	10	in	in	ADP
biomedich-811	123	11	southeast	southeast	PROPN
biomedich-811	123	12	asia	asia	PROPN
biomedich-811	123	13	and	and	CCONJ
biomedich-811	123	14	closely	closely	ADV
biomedich-811	123	15	related	relate	VERB
biomedich-811	123	16	to	to	ADP
biomedich-811	123	17	failure	failure	NOUN
biomedich-811	123	18	mfq	mfq	NOUN
biomedich-811	123	19	and	and	CCONJ
biomedich-811	123	20	lmf	lmf	PROPN
biomedich-811	123	21	treatment	treatment	NOUN
biomedich-811	123	22	;	;	PUNCT
biomedich-811	123	23	it	it	PRON
biomedich-811	123	24	is	be	AUX
biomedich-811	123	25	also	also	ADV
biomedich-811	123	26	common	common	ADJ
biomedich-811	123	27	in	in	ADP
biomedich-811	123	28	south	south	ADJ
biomedich-811	123	29	american	american	ADJ
biomedich-811	123	30	countries	country	NOUN
biomedich-811	123	31	and	and	CCONJ
biomedich-811	123	32	east	east	PROPN
biomedich-811	123	33	and	and	CCONJ
biomedich-811	123	34	west	west	ADJ
biomedich-811	123	35	african	african	ADJ
biomedich-811	123	36	countries	country	NOUN
biomedich-811	123	37	(	(	PUNCT
biomedich-811	123	38	price	price	NOUN
biomedich-811	123	39	et	et	PROPN
biomedich-811	123	40	al	al	PROPN
biomedich-811	123	41	.	.	PROPN
biomedich-811	123	42	,	,	PUNCT
biomedich-811	123	43	2004)(xu	2004)(xu	NUM
biomedich-811	123	44	et	et	NOUN
biomedich-811	123	45	al	al	PROPN
biomedich-811	123	46	.	.	PROPN
biomedich-811	123	47	,	,	PUNCT
biomedich-811	123	48	2018)(mungthin	2018)(mungthin	NUM
biomedich-811	123	49	et	et	NOUN
biomedich-811	123	50	al	al	PROPN
biomedich-811	123	51	.	.	PROPN
biomedich-811	123	52	,	,	PUNCT
biomedich-811	123	53	2010	2010	NUM
biomedich-811	123	54	)	)	PUNCT
biomedich-811	123	55	.	.	PUNCT
biomedich-811	124	1	besides	besides	SCONJ
biomedich-811	124	2	the	the	DET
biomedich-811	124	3	copy	copy	NOUN
biomedich-811	124	4	number	number	NOUN
biomedich-811	124	5	,	,	PUNCT
biomedich-811	124	6	the	the	DET
biomedich-811	124	7	polymorphism	polymorphism	NOUN
biomedich-811	124	8	of	of	ADP
biomedich-811	124	9	the	the	DET
biomedich-811	124	10	pfmdr1	pfmdr1	PROPN
biomedich-811	124	11	gene	gene	NOUN
biomedich-811	124	12	is	be	AUX
biomedich-811	124	13	also	also	ADV
biomedich-811	124	14	associated	associate	VERB
biomedich-811	124	15	with	with	ADP
biomedich-811	124	16	in	in	ADP
biomedich-811	124	17	vivo	vivo	NOUN
biomedich-811	124	18	and	and	CCONJ
biomedich-811	124	19	in	in	ADP
biomedich-811	124	20	vitro	vitro	X
biomedich-811	124	21	parasite	parasite	ADJ
biomedich-811	124	22	reactions	reaction	NOUN
biomedich-811	124	23	to	to	ADP
biomedich-811	124	24	amodiaquine	amodiaquine	PROPN
biomedich-811	124	25	(	(	PUNCT
biomedich-811	124	26	adq	adq	PROPN
biomedich-811	124	27	)	)	PUNCT
biomedich-811	124	28	,	,	PUNCT
biomedich-811	124	29	mfq	mfq	PROPN
biomedich-811	124	30	,	,	PUNCT
biomedich-811	124	31	lmf	lmf	PROPN
biomedich-811	124	32	,	,	PUNCT
biomedich-811	124	33	and	and	CCONJ
biomedich-811	124	34	artemisinin	artemisinin	PROPN
biomedich-811	124	35	(	(	PUNCT
biomedich-811	124	36	mungthin	mungthin	PROPN
biomedich-811	124	37	et	et	PROPN
biomedich-811	124	38	al	al	PROPN
biomedich-811	124	39	.	.	PROPN
biomedich-811	124	40	,	,	PUNCT
biomedich-811	124	41	2010)(price	2010)(price	NUM
biomedich-811	124	42	et	et	NOUN
biomedich-811	124	43	al	al	PROPN
biomedich-811	124	44	.	.	PROPN
biomedich-811	124	45	,	,	PUNCT
biomedich-811	124	46	2004	2004	NUM
biomedich-811	124	47	)	)	PUNCT
biomedich-811	124	48	.	.	PUNCT
biomedich-811	125	1	some	some	DET
biomedich-811	125	2	missense	missense	NOUN
biomedich-811	125	3	mutations	mutation	NOUN
biomedich-811	125	4	are	be	AUX
biomedich-811	125	5	common	common	ADJ
biomedich-811	125	6	in	in	ADP
biomedich-811	125	7	african	african	ADJ
biomedich-811	125	8	and	and	CCONJ
biomedich-811	125	9	asian	asian	ADJ
biomedich-811	125	10	countries	country	NOUN
biomedich-811	125	11	,	,	PUNCT
biomedich-811	125	12	whereas	whereas	SCONJ
biomedich-811	125	13	other	other	ADJ
biomedich-811	125	14	mutations	mutation	NOUN
biomedich-811	125	15	occur	occur	VERB
biomedich-811	125	16	at	at	ADP
biomedich-811	125	17	high	high	ADJ
biomedich-811	125	18	frequency	frequency	NOUN
biomedich-811	125	19	in	in	ADP
biomedich-811	125	20	south	south	ADJ
biomedich-811	125	21	american	american	ADJ
biomedich-811	125	22	parasites	parasite	NOUN
biomedich-811	125	23	(	(	PUNCT
biomedich-811	125	24	adamu	adamu	PROPN
biomedich-811	125	25	et	et	PROPN
biomedich-811	125	26	al	al	PROPN
biomedich-811	125	27	.	.	PROPN
biomedich-811	125	28	,	,	PUNCT
biomedich-811	125	29	2020)(veiga	2020)(veiga	ADV
biomedich-811	125	30	et	et	PROPN
biomedich-811	125	31	al	al	PROPN
biomedich-811	125	32	.	.	PROPN
biomedich-811	125	33	,	,	PUNCT
biomedich-811	125	34	2016	2016	NUM
biomedich-811	125	35	)	)	PUNCT
biomedich-811	125	36	.	.	PUNCT
biomedich-811	126	1	sulistyaningsih	sulistyaningsih	PROPN
biomedich-811	126	2	et	et	PROPN
biomedich-811	126	3	al	al	PROPN
biomedich-811	126	4	.	.	PROPN
biomedich-811	126	5	–	–	PUNCT
biomedich-811	126	6	molecular	molecular	ADJ
biomedich-811	126	7	method	method	NOUN
biomedich-811	126	8	optimization	optimization	NOUN
biomedich-811	126	9	to	to	PART
biomedich-811	126	10	identify	identify	VERB
biomedich-811	126	11	plasmodium	plasmodium	NOUN
biomedich-811	126	12	falciparum	falciparum	NOUN
biomedich-811	126	13	…	…	PUNCT
biomedich-811	126	14	677	677	NUM
biomedich-811	126	15	(	(	PUNCT
biomedich-811	126	16	a	a	NOUN
biomedich-811	126	17	)	)	PUNCT
biomedich-811	126	18	(	(	PUNCT
biomedich-811	126	19	b	b	X
biomedich-811	126	20	)	)	PUNCT
biomedich-811	126	21	figure	figure	NOUN
biomedich-811	126	22	2	2	NUM
biomedich-811	126	23	.	.	PUNCT
biomedich-811	126	24	amplification	amplification	NOUN
biomedich-811	126	25	results	result	NOUN
biomedich-811	126	26	of	of	ADP
biomedich-811	126	27	pfmdr1	pfmdr1	PROPN
biomedich-811	126	28	-	-	PUNCT
biomedich-811	126	29	b	b	PROPN
biomedich-811	126	30	primer	primer	NOUN
biomedich-811	126	31	in	in	ADP
biomedich-811	126	32	different	different	ADJ
biomedich-811	126	33	annealing	anneal	VERB
biomedich-811	126	34	temperatures	temperature	NOUN
biomedich-811	126	35	in	in	ADP
biomedich-811	126	36	nested-1	nested-1	NUM
biomedich-811	126	37	and	and	CCONJ
biomedich-811	126	38	nested-2	nested-2	NUM
biomedich-811	126	39	pcr	pcr	NOUN
biomedich-811	126	40	.	.	PUNCT
biomedich-811	127	1	the	the	DET
biomedich-811	127	2	target	target	NOUN
biomedich-811	127	3	amplicon	amplicon	NOUN
biomedich-811	127	4	is	be	AUX
biomedich-811	127	5	534	534	NUM
biomedich-811	127	6	bp	bp	NOUN
biomedich-811	127	7	.	.	PUNCT
biomedich-811	128	1	(	(	PUNCT
biomedich-811	128	2	a	a	X
biomedich-811	128	3	)	)	PUNCT
biomedich-811	128	4	pcr	pcr	ADJ
biomedich-811	128	5	product	product	NOUN
biomedich-811	128	6	using	use	VERB
biomedich-811	128	7	an	an	DET
biomedich-811	128	8	annealing	anneal	VERB
biomedich-811	128	9	temperature	temperature	NOUN
biomedich-811	128	10	for	for	ADP
biomedich-811	128	11	nested-1	nested-1	NUM
biomedich-811	128	12	:	:	PUNCT
biomedich-811	128	13	55oc	55oc	NOUN
biomedich-811	128	14	,	,	PUNCT
biomedich-811	128	15	and	and	CCONJ
biomedich-811	128	16	nested-2	nested-2	NUM
biomedich-811	128	17	:	:	PUNCT
biomedich-811	128	18	60oc	60oc	NOUN
biomedich-811	128	19	,	,	PUNCT
biomedich-811	128	20	(	(	PUNCT
biomedich-811	128	21	b	b	X
biomedich-811	128	22	)	)	PUNCT
biomedich-811	128	23	pcr	pcr	ADJ
biomedich-811	128	24	product	product	NOUN
biomedich-811	128	25	using	use	VERB
biomedich-811	128	26	an	an	DET
biomedich-811	128	27	annealing	anneal	VERB
biomedich-811	128	28	temperature	temperature	NOUN
biomedich-811	128	29	for	for	ADP
biomedich-811	128	30	nested-1	nested-1	NUM
biomedich-811	128	31	:	:	PUNCT
biomedich-811	128	32	57oc	57oc	ADJ
biomedich-811	128	33	,	,	PUNCT
biomedich-811	128	34	and	and	CCONJ
biomedich-811	128	35	nested-2	nested-2	NUM
biomedich-811	128	36	:	:	PUNCT
biomedich-811	128	37	62oc	62oc	NOUN
biomedich-811	128	38	.	.	PUNCT
biomedich-811	129	1	c-	c-	X
biomedich-811	129	2	:	:	PUNCT
biomedich-811	129	3	negative	negative	ADJ
biomedich-811	129	4	control	control	NOUN
biomedich-811	129	5	;	;	PUNCT
biomedich-811	129	6	line	line	NOUN
biomedich-811	129	7	1	1	NUM
biomedich-811	129	8	:	:	PUNCT
biomedich-811	129	9	patient	patient	ADJ
biomedich-811	129	10	1	1	NUM
biomedich-811	129	11	;	;	PUNCT
biomedich-811	129	12	line	line	NOUN
biomedich-811	129	13	2	2	NUM
biomedich-811	129	14	:	:	PUNCT
biomedich-811	129	15	patient	patient	NOUN
biomedich-811	129	16	2	2	NUM
biomedich-811	129	17	;	;	PUNCT
biomedich-811	129	18	m	m	NUM
biomedich-811	129	19	;	;	PUNCT
biomedich-811	129	20	dna	dna	PROPN
biomedich-811	129	21	marker	marker	NOUN
biomedich-811	129	22	.	.	PUNCT
biomedich-811	130	1	our	our	PRON
biomedich-811	130	2	study	study	NOUN
biomedich-811	130	3	found	find	VERB
biomedich-811	130	4	the	the	DET
biomedich-811	130	5	pfmdr1	pfmdr1	PROPN
biomedich-811	130	6	gene	gene	PROPN
biomedich-811	130	7	,	,	PUNCT
biomedich-811	130	8	i.e.	i.e.	X
biomedich-811	130	9	,	,	PUNCT
biomedich-811	130	10	pfmdr1	pfmdr1	PROPN
biomedich-811	130	11	-	-	PUNCT
biomedich-811	130	12	a	a	PROPN
biomedich-811	130	13	and	and	CCONJ
biomedich-811	130	14	pfmdr1	pfmdr1	PROPN
biomedich-811	130	15	-	-	PUNCT
biomedich-811	130	16	b	b	PROPN
biomedich-811	130	17	,	,	PUNCT
biomedich-811	130	18	in	in	ADP
biomedich-811	130	19	the	the	DET
biomedich-811	130	20	samples	sample	NOUN
biomedich-811	130	21	after	after	ADP
biomedich-811	130	22	a	a	DET
biomedich-811	130	23	pcr	pcr	ADJ
biomedich-811	130	24	optimization	optimization	NOUN
biomedich-811	130	25	,	,	PUNCT
biomedich-811	130	26	indicating	indicate	VERB
biomedich-811	130	27	potential	potential	ADJ
biomedich-811	130	28	evidence	evidence	NOUN
biomedich-811	130	29	of	of	ADP
biomedich-811	130	30	antimalarial	antimalarial	ADJ
biomedich-811	130	31	resistance	resistance	NOUN
biomedich-811	130	32	in	in	ADP
biomedich-811	130	33	the	the	DET
biomedich-811	130	34	parasite	parasite	ADJ
biomedich-811	130	35	population	population	NOUN
biomedich-811	130	36	.	.	PUNCT
biomedich-811	131	1	this	this	DET
biomedich-811	131	2	pcr	pcr	NOUN
biomedich-811	131	3	setting	setting	NOUN
biomedich-811	131	4	can	can	AUX
biomedich-811	131	5	be	be	AUX
biomedich-811	131	6	used	use	VERB
biomedich-811	131	7	for	for	ADP
biomedich-811	131	8	further	further	ADJ
biomedich-811	131	9	antimalarial	antimalarial	ADJ
biomedich-811	131	10	resistance	resistance	NOUN
biomedich-811	131	11	gene	gene	NOUN
biomedich-811	131	12	identification	identification	NOUN
biomedich-811	131	13	.	.	PUNCT
biomedich-811	132	1	examination	examination	NOUN
biomedich-811	132	2	of	of	ADP
biomedich-811	132	3	the	the	DET
biomedich-811	132	4	gene	gene	NOUN
biomedich-811	132	5	copy	copy	NOUN
biomedich-811	132	6	number	number	NOUN
biomedich-811	132	7	and	and	CCONJ
biomedich-811	132	8	the	the	DET
biomedich-811	132	9	gene	gene	NOUN
biomedich-811	132	10	polymorphism	polymorphism	NOUN
biomedich-811	132	11	is	be	AUX
biomedich-811	132	12	vital	vital	ADJ
biomedich-811	132	13	for	for	ADP
biomedich-811	132	14	further	far	ADV
biomedich-811	132	15	determining	determine	VERB
biomedich-811	132	16	the	the	DET
biomedich-811	132	17	definitive	definitive	ADJ
biomedich-811	132	18	conclusion	conclusion	NOUN
biomedich-811	132	19	regarding	regard	VERB
biomedich-811	132	20	antimalarial	antimalarial	ADJ
biomedich-811	132	21	resistance	resistance	NOUN
biomedich-811	132	22	.	.	PUNCT
biomedich-811	133	1	conclusions	conclusion	NOUN
biomedich-811	133	2	the	the	DET
biomedich-811	133	3	study	study	NOUN
biomedich-811	133	4	has	have	AUX
biomedich-811	133	5	determined	determine	VERB
biomedich-811	133	6	the	the	DET
biomedich-811	133	7	pcr	pcr	NOUN
biomedich-811	133	8	setting	setting	NOUN
biomedich-811	133	9	to	to	PART
biomedich-811	133	10	identify	identify	VERB
biomedich-811	133	11	the	the	DET
biomedich-811	133	12	pfmdr1	pfmdr1	NOUN
biomedich-811	133	13	genes	gene	NOUN
biomedich-811	133	14	,	,	PUNCT
biomedich-811	133	15	i.e.	i.e.	X
biomedich-811	133	16	,	,	PUNCT
biomedich-811	133	17	pfmdr1	pfmdr1	PROPN
biomedich-811	133	18	-	-	PUNCT
biomedich-811	133	19	a	a	PROPN
biomedich-811	133	20	and	and	CCONJ
biomedich-811	133	21	pfmdr1	pfmdr1	PROPN
biomedich-811	133	22	-	-	PUNCT
biomedich-811	133	23	b	b	PROPN
biomedich-811	133	24	in	in	ADP
biomedich-811	133	25	the	the	DET
biomedich-811	133	26	samples	sample	NOUN
biomedich-811	133	27	.	.	PUNCT
biomedich-811	134	1	the	the	DET
biomedich-811	134	2	positive	positive	ADJ
biomedich-811	134	3	amplification	amplification	NOUN
biomedich-811	134	4	results	result	NOUN
biomedich-811	134	5	indicate	indicate	VERB
biomedich-811	134	6	potential	potential	ADJ
biomedich-811	134	7	evidence	evidence	NOUN
biomedich-811	134	8	of	of	ADP
biomedich-811	134	9	antimalarial	antimalarial	ADJ
biomedich-811	134	10	resistance	resistance	NOUN
biomedich-811	134	11	in	in	ADP
biomedich-811	134	12	the	the	DET
biomedich-811	134	13	parasite	parasite	ADJ
biomedich-811	134	14	population	population	NOUN
biomedich-811	134	15	.	.	PUNCT
biomedich-811	135	1	further	further	ADJ
biomedich-811	135	2	examination	examination	NOUN
biomedich-811	135	3	of	of	ADP
biomedich-811	135	4	the	the	DET
biomedich-811	135	5	gene	gene	NOUN
biomedich-811	135	6	copy	copy	NOUN
biomedich-811	135	7	number	number	NOUN
biomedich-811	135	8	and	and	CCONJ
biomedich-811	135	9	the	the	DET
biomedich-811	135	10	gene	gene	NOUN
biomedich-811	135	11	polymorphism	polymorphism	NOUN
biomedich-811	135	12	is	be	AUX
biomedich-811	135	13	vital	vital	ADJ
biomedich-811	135	14	to	to	PART
biomedich-811	135	15	determine	determine	VERB
biomedich-811	135	16	the	the	DET
biomedich-811	135	17	definitive	definitive	ADJ
biomedich-811	135	18	antimalarial	antimalarial	ADJ
biomedich-811	135	19	resistance	resistance	NOUN
biomedich-811	135	20	.	.	PUNCT
biomedich-811	136	1	some	some	DET
biomedich-811	136	2	specific	specific	ADJ
biomedich-811	136	3	primers	primer	NOUN
biomedich-811	136	4	targeting	target	VERB
biomedich-811	136	5	the	the	DET
biomedich-811	136	6	pfmdr1	pfmdr1	PROPN
biomedich-811	136	7	gene	gene	NOUN
biomedich-811	136	8	have	have	AUX
biomedich-811	136	9	been	be	AUX
biomedich-811	136	10	designed	design	VERB
biomedich-811	136	11	.	.	PUNCT
biomedich-811	137	1	however	however	ADV
biomedich-811	137	2	,	,	PUNCT
biomedich-811	137	3	the	the	DET
biomedich-811	137	4	pcr	pcr	NOUN
biomedich-811	137	5	setting	setting	NOUN
biomedich-811	137	6	should	should	AUX
biomedich-811	137	7	be	be	AUX
biomedich-811	137	8	optimized	optimize	VERB
biomedich-811	137	9	based	base	VERB
biomedich-811	137	10	on	on	ADP
biomedich-811	137	11	the	the	DET
biomedich-811	137	12	individual	individual	ADJ
biomedich-811	137	13	laboratory	laboratory	NOUN
biomedich-811	137	14	conditions	condition	NOUN
biomedich-811	137	15	to	to	PART
biomedich-811	137	16	get	get	VERB
biomedich-811	137	17	the	the	DET
biomedich-811	137	18	expected	expect	VERB
biomedich-811	137	19	results	result	NOUN
biomedich-811	137	20	.	.	PUNCT
biomedich-811	138	1	acknowledgements	acknowledgement	NOUN
biomedich-811	138	2	:	:	PUNCT
biomedich-811	138	3	the	the	DET
biomedich-811	138	4	authors	author	NOUN
biomedich-811	138	5	thank	thank	VERB
biomedich-811	138	6	study	study	NOUN
biomedich-811	138	7	participants	participant	NOUN
biomedich-811	138	8	and	and	CCONJ
biomedich-811	138	9	collaborators	collaborator	NOUN
biomedich-811	138	10	from	from	ADP
biomedich-811	138	11	some	some	DET
biomedich-811	138	12	districts	district	NOUN
biomedich-811	138	13	in	in	ADP
biomedich-811	138	14	kerom	kerom	PROPN
biomedich-811	138	15	regency	regency	PROPN
biomedich-811	138	16	,	,	PUNCT
biomedich-811	138	17	papua	papua	PROPN
biomedich-811	138	18	province	province	PROPN
biomedich-811	138	19	.	.	PUNCT
biomedich-811	139	1	authors	author	NOUN
biomedich-811	139	2	’	'	PUNCT
biomedich-811	139	3	contributions	contribution	NOUN
biomedich-811	139	4	:	:	PUNCT
biomedich-811	139	5	erma	erma	PROPN
biomedich-811	139	6	sulistyaningsih	sulistyaningsih	PROPN
biomedich-811	139	7	designed	design	VERB
biomedich-811	139	8	the	the	DET
biomedich-811	139	9	study	study	NOUN
biomedich-811	139	10	,	,	PUNCT
biomedich-811	139	11	analyzed	analyze	VERB
biomedich-811	139	12	the	the	DET
biomedich-811	139	13	data	datum	NOUN
biomedich-811	139	14	,	,	PUNCT
biomedich-811	139	15	and	and	CCONJ
biomedich-811	139	16	wrote	write	VERB
biomedich-811	139	17	the	the	DET
biomedich-811	139	18	manuscript	manuscript	NOUN
biomedich-811	139	19	.	.	PUNCT
biomedich-811	140	1	rosita	rosita	PROPN
biomedich-811	140	2	dewi	dewi	PROPN
biomedich-811	140	3	and	and	CCONJ
biomedich-811	140	4	sheilla	sheilla	PROPN
biomedich-811	140	5	rachmania	rachmania	NOUN
biomedich-811	140	6	analyzed	analyze	VERB
biomedich-811	140	7	the	the	DET
biomedich-811	140	8	data	datum	NOUN
biomedich-811	140	9	.	.	PUNCT
biomedich-811	141	1	irawan	irawan	PROPN
biomedich-811	141	2	fajar	fajar	PROPN
biomedich-811	141	3	kusuma	kusuma	PROPN
biomedich-811	141	4	,	,	PUNCT
biomedich-811	141	5	muhammad	muhammad	PROPN
biomedich-811	141	6	rizqi	rizqi	PROPN
biomedich-811	141	7	kholifaturrohmy	kholifaturrohmy	PROPN
biomedich-811	141	8	,	,	PUNCT
biomedich-811	141	9	and	and	CCONJ
biomedich-811	141	10	yunita	yunita	PROPN
biomedich-811	141	11	armiyanti	armiyanti	PROPN
biomedich-811	141	12	collected	collect	VERB
biomedich-811	141	13	the	the	DET
biomedich-811	141	14	samples	sample	NOUN
biomedich-811	141	15	.	.	PUNCT
biomedich-811	142	1	sakinatus	sakinatus	PROPN
biomedich-811	142	2	sariroh	sariroh	PROPN
biomedich-811	142	3	kholifaturrohmah	kholifaturrohmah	PROPN
biomedich-811	142	4	and	and	CCONJ
biomedich-811	142	5	made	make	VERB
biomedich-811	142	6	prasanti	prasanti	PROPN
biomedich-811	142	7	andriani	andriani	PROPN
biomedich-811	142	8	carried	carry	VERB
biomedich-811	142	9	out	out	ADP
biomedich-811	142	10	the	the	DET
biomedich-811	142	11	laboratory	laboratory	NOUN
biomedich-811	142	12	work	work	NOUN
biomedich-811	142	13	.	.	PUNCT
biomedich-811	143	1	all	all	DET
biomedich-811	143	2	authors	author	NOUN
biomedich-811	143	3	read	read	VERB
biomedich-811	143	4	and	and	CCONJ
biomedich-811	143	5	approved	approve	VERB
biomedich-811	143	6	the	the	DET
biomedich-811	143	7	final	final	ADJ
biomedich-811	143	8	version	version	NOUN
biomedich-811	143	9	of	of	ADP
biomedich-811	143	10	the	the	DET
biomedich-811	143	11	manuscript	manuscript	NOUN
biomedich-811	143	12	.	.	PUNCT
biomedich-811	144	1	competing	compete	VERB
biomedich-811	144	2	interests	interest	NOUN
biomedich-811	144	3	:	:	PUNCT
biomedich-811	144	4	the	the	DET
biomedich-811	144	5	authors	author	NOUN
biomedich-811	144	6	declare	declare	VERB
biomedich-811	144	7	that	that	SCONJ
biomedich-811	144	8	there	there	PRON
biomedich-811	144	9	are	be	VERB
biomedich-811	144	10	no	no	DET
biomedich-811	144	11	competing	compete	VERB
biomedich-811	144	12	interests	interest	NOUN
biomedich-811	144	13	.	.	PUNCT
biomedich-811	145	1	funding	funding	NOUN
biomedich-811	145	2	:	:	PUNCT
biomedich-811	145	3	the	the	DET
biomedich-811	145	4	study	study	NOUN
biomedich-811	145	5	was	be	AUX
biomedich-811	145	6	funded	fund	VERB
biomedich-811	145	7	by	by	ADP
biomedich-811	145	8	the	the	DET
biomedich-811	145	9	university	university	PROPN
biomedich-811	145	10	of	of	ADP
biomedich-811	145	11	jember	jember	PROPN
biomedich-811	145	12	through	through	ADP
biomedich-811	145	13	the	the	DET
biomedich-811	145	14	internal	internal	ADJ
biomedich-811	145	15	grant	grant	NOUN
biomedich-811	145	16	for	for	ADP
biomedich-811	145	17	malaria	malaria	NOUN
biomedich-811	145	18	research	research	NOUN
biomedich-811	145	19	group	group	NOUN
biomedich-811	145	20	2024	2024	NUM
biomedich-811	145	21	.	.	PUNCT
biomedich-811	146	1	references	reference	NOUN
biomedich-811	146	2	adamu	adamu	PROPN
biomedich-811	146	3	,	,	PUNCT
biomedich-811	146	4	a.	a.	PROPN
biomedich-811	146	5	,	,	PUNCT
biomedich-811	146	6	jada	jada	PROPN
biomedich-811	146	7	,	,	PUNCT
biomedich-811	146	8	m.	m.	PROPN
biomedich-811	146	9	s.	s.	PROPN
biomedich-811	146	10	,	,	PUNCT
biomedich-811	146	11	haruna	haruna	PROPN
biomedich-811	146	12	,	,	PUNCT
biomedich-811	146	13	h.	h.	PROPN
biomedich-811	146	14	m.	m.	PROPN
biomedich-811	146	15	s.	s.	PROPN
biomedich-811	146	16	,	,	PUNCT
biomedich-811	146	17	yakubu	yakubu	PROPN
biomedich-811	146	18	,	,	PUNCT
biomedich-811	146	19	b.	b.	PROPN
biomedich-811	146	20	o.	o.	PROPN
biomedich-811	146	21	,	,	PUNCT
biomedich-811	146	22	ibrahim	ibrahim	PROPN
biomedich-811	146	23	,	,	PUNCT
biomedich-811	146	24	m.	m.	NOUN
biomedich-811	146	25	a.	a.	PROPN
biomedich-811	146	26	,	,	PUNCT
biomedich-811	146	27	balogun	balogun	VERB
biomedich-811	146	28	,	,	PUNCT
biomedich-811	146	29	e.	e.	PROPN
biomedich-811	146	30	o.	o.	PROPN
biomedich-811	146	31	,	,	PUNCT
biomedich-811	146	32	sakura	sakura	NOUN
biomedich-811	146	33	,	,	PUNCT
biomedich-811	146	34	t.	t.	PROPN
biomedich-811	146	35	,	,	PUNCT
biomedich-811	146	36	inaoka	inaoka	PROPN
biomedich-811	146	37	,	,	PUNCT
biomedich-811	146	38	d.	d.	PROPN
biomedich-811	146	39	k.	k.	PROPN
biomedich-811	146	40	,	,	PUNCT
biomedich-811	146	41	kita	kita	PROPN
biomedich-811	146	42	,	,	PUNCT
biomedich-811	146	43	k.	k.	PROPN
biomedich-811	146	44	,	,	PUNCT
biomedich-811	146	45	hirayama	hirayama	PROPN
biomedich-811	146	46	,	,	PUNCT
biomedich-811	146	47	k.	k.	PROPN
biomedich-811	146	48	,	,	PUNCT
biomedich-811	146	49	culleton	culleton	PROPN
biomedich-811	146	50	,	,	PUNCT
biomedich-811	146	51	r.	r.	PROPN
biomedich-811	146	52	,	,	PUNCT
biomedich-811	146	53	&	&	CCONJ
biomedich-811	146	54	shuaibu	shuaibu	NOUN
biomedich-811	146	55	,	,	PUNCT
biomedich-811	146	56	m.	m.	NOUN
biomedich-811	146	57	n.	n.	PROPN
biomedich-811	146	58	(	(	PUNCT
biomedich-811	146	59	2020	2020	NUM
biomedich-811	146	60	)	)	PUNCT
biomedich-811	146	61	.	.	PUNCT
biomedich-811	147	1	plasmodium	plasmodium	NOUN
biomedich-811	147	2	falciparum	falciparum	ADJ
biomedich-811	147	3	multidrug	multidrug	NOUN
biomedich-811	147	4	resistance	resistance	NOUN
biomedich-811	147	5	gene-1	gene-1	PROPN
biomedich-811	147	6	polymorphisms	polymorphism	NOUN
biomedich-811	147	7	in	in	ADP
biomedich-811	147	8	northern	northern	PROPN
biomedich-811	147	9	nigeria	nigeria	PROPN
biomedich-811	147	10	:	:	PUNCT
biomedich-811	147	11	implications	implication	NOUN
biomedich-811	147	12	for	for	ADP
biomedich-811	147	13	the	the	DET
biomedich-811	147	14	continued	continue	VERB
biomedich-811	147	15	use	use	NOUN
biomedich-811	147	16	of	of	ADP
biomedich-811	147	17	artemether	artemether	ADJ
biomedich-811	147	18	-	-	PUNCT
biomedich-811	147	19	lumefantrine	lumefantrine	NOUN
biomedich-811	147	20	in	in	ADP
biomedich-811	147	21	the	the	DET
biomedich-811	147	22	region	region	NOUN
biomedich-811	147	23	.	.	PUNCT
biomedich-811	148	1	malaria	malaria	PROPN
biomedich-811	148	2	journal	journal	PROPN
biomedich-811	148	3	,	,	PUNCT
biomedich-811	148	4	19(1	19(1	NUM
biomedich-811	148	5	)	)	PUNCT
biomedich-811	148	6	,	,	PUNCT
biomedich-811	148	7	1–10	1–10	NOUN
biomedich-811	148	8	.	.	PUNCT
biomedich-811	149	1	https://doi.org/10.1186/s12936020-03506-z	https://doi.org/10.1186/s12936020-03506-z	PROPN
biomedich-811	149	2	al	al	PROPN
biomedich-811	149	3	-	-	PUNCT
biomedich-811	149	4	mekhlafi	mekhlafi	PROPN
biomedich-811	149	5	,	,	PUNCT
biomedich-811	149	6	h.	h.	PROPN
biomedich-811	149	7	m.	m.	PROPN
biomedich-811	149	8	,	,	PUNCT
biomedich-811	149	9	madkhali	madkhali	PROPN
biomedich-811	149	10	,	,	PUNCT
biomedich-811	149	11	a.	a.	NOUN
biomedich-811	149	12	m.	m.	NOUN
biomedich-811	149	13	,	,	PUNCT
biomedich-811	149	14	abdulhaq	abdulhaq	VERB
biomedich-811	149	15	,	,	PUNCT
biomedich-811	149	16	a.	a.	NOUN
biomedich-811	149	17	a.	a.	PROPN
biomedich-811	149	18	,	,	PUNCT
biomedich-811	149	19	atroosh	atroosh	PROPN
biomedich-811	149	20	,	,	PUNCT
biomedich-811	149	21	w.	w.	PROPN
biomedich-811	149	22	m.	m.	PROPN
biomedich-811	149	23	,	,	PUNCT
biomedich-811	149	24	ghzwani	ghzwani	PROPN
biomedich-811	149	25	,	,	PUNCT
biomedich-811	149	26	a.	a.	PROPN
biomedich-811	149	27	h.	h.	PROPN
biomedich-811	149	28	,	,	PUNCT
biomedich-811	149	29	zain	zain	PROPN
biomedich-811	149	30	,	,	PUNCT
biomedich-811	149	31	k.	k.	PROPN
biomedich-811	149	32	a.	a.	PROPN
biomedich-811	149	33	,	,	PUNCT
biomedich-811	149	34	ghailan	ghailan	NOUN
biomedich-811	149	35	,	,	PUNCT
biomedich-811	149	36	k.	k.	PROPN
biomedich-811	149	37	y.	y.	PROPN
biomedich-811	149	38	,	,	PUNCT
biomedich-811	149	39	hamali	hamali	PROPN
biomedich-811	149	40	,	,	PUNCT
biomedich-811	149	41	h.	h.	PROPN
biomedich-811	149	42	a.	a.	PROPN
biomedich-811	149	43	,	,	PUNCT
biomedich-811	149	44	mobarki	mobarki	NOUN
biomedich-811	149	45	,	,	PUNCT
biomedich-811	149	46	a.	a.	NOUN
biomedich-811	149	47	a.	a.	PROPN
biomedich-811	149	48	,	,	PUNCT
biomedich-811	149	49	alharazi	alharazi	PROPN
biomedich-811	149	50	,	,	PUNCT
biomedich-811	149	51	t.	t.	PROPN
biomedich-811	149	52	h.	h.	PROPN
biomedich-811	149	53	,	,	PUNCT
biomedich-811	149	54	eisa	eisa	PROPN
biomedich-811	149	55	,	,	PUNCT
biomedich-811	149	56	z.	z.	PROPN
biomedich-811	149	57	m.	m.	PROPN
biomedich-811	149	58	,	,	PUNCT
biomedich-811	149	59	&	&	CCONJ
biomedich-811	149	60	lau	lau	PROPN
biomedich-811	149	61	,	,	PUNCT
biomedich-811	149	62	y.	y.	PROPN
biomedich-811	149	63	l.	l.	PROPN
biomedich-811	149	64	(	(	PUNCT
biomedich-811	149	65	2022	2022	NUM
biomedich-811	149	66	)	)	PUNCT
biomedich-811	149	67	.	.	PUNCT
biomedich-811	150	1	polymorphism	polymorphism	NOUN
biomedich-811	150	2	analysis	analysis	NOUN
biomedich-811	150	3	of	of	ADP
biomedich-811	150	4	pfmdr1	pfmdr1	PROPN
biomedich-811	150	5	gene	gene	PROPN
biomedich-811	150	6	in	in	ADP
biomedich-811	150	7	plasmodium	plasmodium	NOUN
biomedich-811	150	8	falciparum	falciparum	ADJ
biomedich-811	150	9	isolates	isolate	NOUN
biomedich-811	150	10	11	11	NUM
biomedich-811	150	11	years	year	NOUN
biomedich-811	150	12	post	post	NOUN
biomedich-811	150	13	-	-	NOUN
biomedich-811	150	14	adoption	adoption	NOUN
biomedich-811	150	15	of	of	ADP
biomedich-811	150	16	artemisinin	artemisinin	NOUN
biomedich-811	150	17	-	-	PUNCT
biomedich-811	150	18	based	base	VERB
biomedich-811	150	19	combination	combination	NOUN
biomedich-811	150	20	therapy	therapy	NOUN
biomedich-811	150	21	in	in	ADP
biomedich-811	150	22	saudi	saudi	PROPN
biomedich-811	150	23	arabia	arabia	PROPN
biomedich-811	150	24	.	.	PUNCT
biomedich-811	151	1	scientific	scientific	ADJ
biomedich-811	151	2	reports	report	NOUN
biomedich-811	151	3	,	,	PUNCT
biomedich-811	151	4	12(1	12(1	NUM
biomedich-811	151	5	)	)	PUNCT
biomedich-811	151	6	,	,	PUNCT
biomedich-811	151	7	1–13	1–13	NOUN
biomedich-811	151	8	.	.	PUNCT
biomedich-811	152	1	https://doi.org/10.1038/s41598-021-04450-x	https://doi.org/10.1038/s41598-021-04450-x	PROPN
biomedich-811	152	2	dondorp	dondorp	PROPN
biomedich-811	152	3	,	,	PUNCT
biomedich-811	152	4	a.	a.	NOUN
biomedich-811	152	5	m.	m.	NOUN
biomedich-811	152	6	,	,	PUNCT
biomedich-811	152	7	nosten	nosten	PROPN
biomedich-811	152	8	,	,	PUNCT
biomedich-811	152	9	f.	f.	PROPN
biomedich-811	152	10	,	,	PUNCT
biomedich-811	152	11	yi	yi	PROPN
biomedich-811	152	12	,	,	PUNCT
biomedich-811	152	13	p.	p.	PROPN
biomedich-811	152	14	,	,	PUNCT
biomedich-811	152	15	das	das	PROPN
biomedich-811	152	16	,	,	PUNCT
biomedich-811	152	17	d.	d.	PROPN
biomedich-811	152	18	,	,	PUNCT
biomedich-811	152	19	hanpithakpong	hanpithakpong	PROPN
biomedich-811	152	20	,	,	PUNCT
biomedich-811	152	21	w.	w.	PROPN
biomedich-811	152	22	,	,	PUNCT
biomedich-811	152	23	ph	ph	PROPN
biomedich-811	152	24	,	,	PUNCT
biomedich-811	152	25	d.	d.	PROPN
biomedich-811	152	26	,	,	PUNCT
biomedich-811	152	27	lee	lee	PROPN
biomedich-811	152	28	,	,	PUNCT
biomedich-811	152	29	s.	s.	PROPN
biomedich-811	152	30	j.	j.	PROPN
biomedich-811	152	31	,	,	PUNCT
biomedich-811	152	32	ph	ph	PROPN
biomedich-811	152	33	,	,	PUNCT
biomedich-811	152	34	d.	d.	PROPN
biomedich-811	152	35	,	,	PUNCT
biomedich-811	152	36	ringwald	ringwald	PROPN
biomedich-811	152	37	,	,	PUNCT
biomedich-811	152	38	p.	p.	PROPN
biomedich-811	152	39	,	,	PUNCT
biomedich-811	152	40	ph	ph	PROPN
biomedich-811	152	41	,	,	PUNCT
biomedich-811	152	42	d.	d.	PROPN
biomedich-811	152	43	,	,	PUNCT
biomedich-811	152	44	imwong	imwong	ADJ
biomedich-811	152	45	,	,	PUNCT
biomedich-811	152	46	m.	m.	NOUN
biomedich-811	152	47	,	,	PUNCT
biomedich-811	152	48	ph	ph	PROPN
biomedich-811	152	49	,	,	PUNCT
biomedich-811	152	50	d.	d.	PROPN
biomedich-811	152	51	,	,	PUNCT
biomedich-811	152	52	chotivanich	chotivanich	PROPN
biomedich-811	152	53	,	,	PUNCT
biomedich-811	152	54	k.	k.	PROPN
biomedich-811	152	55	,	,	PUNCT
biomedich-811	152	56	ph	ph	PROPN
biomedich-811	152	57	,	,	PUNCT
biomedich-811	152	58	d.	d.	PROPN
biomedich-811	152	59	,	,	PUNCT
biomedich-811	152	60	&	&	CCONJ
biomedich-811	152	61	lim	lim	PROPN
biomedich-811	152	62	,	,	PUNCT
biomedich-811	152	63	p.	p.	PROPN
biomedich-811	152	64	(	(	PUNCT
biomedich-811	152	65	2009	2009	NUM
biomedich-811	152	66	)	)	PUNCT
biomedich-811	152	67	.	.	PUNCT
biomedich-811	153	1	artemisinin	artemisinin	PROPN
biomedich-811	153	2	resistance	resistance	NOUN
biomedich-811	153	3	in	in	ADP
biomedich-811	153	4	plasmodium	plasmodium	NOUN
biomedich-811	153	5	falciparum	falciparum	NOUN
biomedich-811	153	6	malaria	malaria	NOUN
biomedich-811	153	7	.	.	PUNCT
biomedich-811	154	1	new	new	PROPN
biomedich-811	154	2	england	england	PROPN
biomedich-811	154	3	journal	journal	PROPN
biomedich-811	154	4	of	of	ADP
biomedich-811	154	5	medicine	medicine	NOUN
biomedich-811	154	6	,	,	PUNCT
biomedich-811	154	7	361(17	361(17	NUM
biomedich-811	154	8	)	)	PUNCT
biomedich-811	154	9	,	,	PUNCT
biomedich-811	154	10	1714–1714	1714–1714	NUM
biomedich-811	154	11	.	.	PUNCT
biomedich-811	155	1	https://doi.org/10.1056/nejmx090050	https://doi.org/10.1056/nejmx090050	PROPN
biomedich-811	155	2	fairhurst	fairhurst	PROPN
biomedich-811	155	3	,	,	PUNCT
biomedich-811	155	4	r.	r.	PROPN
biomedich-811	155	5	m.	m.	PROPN
biomedich-811	155	6	(	(	PUNCT
biomedich-811	155	7	2015	2015	NUM
biomedich-811	155	8	)	)	PUNCT
biomedich-811	155	9	.	.	PUNCT
biomedich-811	156	1	understanding	understand	VERB
biomedich-811	156	2	artemisinin	artemisinin	NOUN
biomedich-811	156	3	-	-	PUNCT
biomedich-811	156	4	resistant	resistant	ADJ
biomedich-811	156	5	malaria	malaria	NOUN
biomedich-811	156	6	.	.	PUNCT
biomedich-811	157	1	current	current	ADJ
biomedich-811	157	2	opinion	opinion	NOUN
biomedich-811	157	3	in	in	ADP
biomedich-811	157	4	infectious	infectious	ADJ
biomedich-811	157	5	diseases	disease	NOUN
biomedich-811	157	6	,	,	PUNCT
biomedich-811	157	7	28(5	28(5	NUM
biomedich-811	157	8	)	)	PUNCT
biomedich-811	157	9	,	,	PUNCT
biomedich-811	157	10	417	417	NUM
biomedich-811	157	11	–	–	PUNCT
biomedich-811	157	12	425	425	NUM
biomedich-811	157	13	.	.	PUNCT
biomedich-811	158	1	https://doi.org/10.1097/qco.0000000000000199	https://doi.org/10.1097/qco.0000000000000199	PROPN
biomedich-811	158	2	fitri	fitri	PROPN
biomedich-811	158	3	,	,	PUNCT
biomedich-811	158	4	l.	l.	PROPN
biomedich-811	158	5	e.	e.	PROPN
biomedich-811	158	6	,	,	PUNCT
biomedich-811	158	7	pawestri	pawestri	PROPN
biomedich-811	158	8	,	,	PUNCT
biomedich-811	158	9	a.	a.	PROPN
biomedich-811	158	10	r.	r.	PROPN
biomedich-811	158	11	,	,	PUNCT
biomedich-811	158	12	winaris	winaris	VERB
biomedich-811	158	13	,	,	PUNCT
biomedich-811	158	14	n.	n.	NOUN
biomedich-811	158	15	,	,	PUNCT
biomedich-811	158	16	endharti	endharti	PROPN
biomedich-811	158	17	,	,	PUNCT
biomedich-811	158	18	a.	a.	NOUN
biomedich-811	158	19	t.	t.	PROPN
biomedich-811	158	20	,	,	PUNCT
biomedich-811	158	21	khotimah	khotimah	PROPN
biomedich-811	158	22	,	,	PUNCT
biomedich-811	158	23	a.	a.	PROPN
biomedich-811	158	24	r.	r.	PROPN
biomedich-811	158	25	h.	h.	PROPN
biomedich-811	158	26	,	,	PUNCT
biomedich-811	158	27	abidah	abidah	PROPN
biomedich-811	158	28	,	,	PUNCT
biomedich-811	158	29	h.	h.	PROPN
biomedich-811	158	30	y.	y.	PROPN
biomedich-811	158	31	,	,	PUNCT
biomedich-811	158	32	&	&	CCONJ
biomedich-811	158	33	huwae	huwae	PROPN
biomedich-811	158	34	,	,	PUNCT
biomedich-811	158	35	j.	j.	PROPN
biomedich-811	158	36	t.	t.	PROPN
biomedich-811	158	37	r.	r.	PROPN
biomedich-811	158	38	(	(	PUNCT
biomedich-811	158	39	2023	2023	NUM
biomedich-811	158	40	)	)	PUNCT
biomedich-811	158	41	.	.	PUNCT
biomedich-811	159	1	antimalarial	antimalarial	ADJ
biomedich-811	159	2	drug	drug	NOUN
biomedich-811	159	3	resistance	resistance	NOUN
biomedich-811	159	4	:	:	PUNCT
biomedich-811	159	5	a	a	DET
biomedich-811	159	6	brief	brief	ADJ
biomedich-811	159	7	history	history	NOUN
biomedich-811	159	8	of	of	ADP
biomedich-811	159	9	its	its	PRON
biomedich-811	159	10	spread	spread	NOUN
biomedich-811	159	11	in	in	ADP
biomedich-811	159	12	indonesia	indonesia	PROPN
biomedich-811	159	13	.	.	PUNCT
biomedich-811	160	1	drug	drug	PROPN
biomedich-811	160	2	design	design	PROPN
biomedich-811	160	3	,	,	PUNCT
biomedich-811	160	4	development	development	NOUN
biomedich-811	160	5	and	and	CCONJ
biomedich-811	160	6	therapy	therapy	NOUN
biomedich-811	160	7	,	,	PUNCT
biomedich-811	160	8	17(april	17(april	NUM
biomedich-811	160	9	)	)	PUNCT
biomedich-811	160	10	,	,	PUNCT
biomedich-811	160	11	1995–2010	1995–2010	NUM
biomedich-811	160	12	.	.	PUNCT
biomedich-811	161	1	https://doi.org/10.2147/dddt.s403672	https://doi.org/10.2147/dddt.s403672	PROPN
biomedich-811	161	2	green	green	PROPN
biomedich-811	161	3	,	,	PUNCT
biomedich-811	161	4	m.	m.	NOUN
biomedich-811	161	5	r.	r.	PROPN
biomedich-811	161	6	,	,	PUNCT
biomedich-811	161	7	&	&	CCONJ
biomedich-811	161	8	sambrook	sambrook	PROPN
biomedich-811	161	9	,	,	PUNCT
biomedich-811	161	10	j.	j.	PROPN
biomedich-811	161	11	(	(	PUNCT
biomedich-811	161	12	2019	2019	NUM
biomedich-811	161	13	)	)	PUNCT
biomedich-811	161	14	.	.	PUNCT
biomedich-811	162	1	nested	nested	ADJ
biomedich-811	162	2	polymerase	polymerase	NOUN
biomedich-811	162	3	chain	chain	NOUN
biomedich-811	162	4	reaction	reaction	NOUN
biomedich-811	162	5	(	(	PUNCT
biomedich-811	162	6	pcr	pcr	PROPN
biomedich-811	162	7	)	)	PUNCT
biomedich-811	162	8	.	.	PUNCT
biomedich-811	163	1	cold	cold	ADJ
biomedich-811	163	2	spring	spring	NOUN
biomedich-811	163	3	harbor	harbor	NOUN
biomedich-811	163	4	protocols	protocol	NOUN
biomedich-811	163	5	,	,	PUNCT
biomedich-811	163	6	2019(2	2019(2	NUM
biomedich-811	163	7	)	)	PUNCT
biomedich-811	163	8	.	.	PUNCT
biomedich-811	164	1	https://doi.org/10.1101/pdb.prot095182	https://doi.org/10.1101/pdb.prot095182	PROPN
biomedich-811	164	2	kemenkes	kemenkes	PROPN
biomedich-811	164	3	,	,	PUNCT
biomedich-811	164	4	r.	r.	PROPN
biomedich-811	164	5	(	(	PUNCT
biomedich-811	164	6	2022	2022	NUM
biomedich-811	164	7	)	)	PUNCT
biomedich-811	164	8	.	.	PUNCT
biomedich-811	165	1	rencana	rencana	PROPN
biomedich-811	165	2	kerja	kerja	PROPN
biomedich-811	165	3	tahunan	tahunan	PROPN
biomedich-811	165	4	direktorat	direktorat	PROPN
biomedich-811	165	5	jenderal	jenderal	PROPN
biomedich-811	165	6	tenaga	tenaga	PROPN
biomedich-811	165	7	kesehatan	kesehatan	PROPN
biomedich-811	165	8	2022	2022	NUM
biomedich-811	165	9	.	.	PUNCT
biomedich-811	166	1	in	in	ADP
biomedich-811	166	2	direktorat	direktorat	PROPN
biomedich-811	166	3	jenderal	jenderal	PROPN
biomedich-811	166	4	tenaga	tenaga	PROPN
biomedich-811	166	5	kesehatan	kesehatan	PROPN
biomedich-811	166	6	kementrian	kementrian	PROPN
biomedich-811	166	7	kesehatan	kesehatan	PROPN
biomedich-811	166	8	republik	republik	PROPN
biomedich-811	166	9	indonesia	indonesia	PROPN
biomedich-811	166	10	(	(	PUNCT
biomedich-811	166	11	vol	vol	NOUN
biomedich-811	166	12	.	.	NOUN
biomedich-811	166	13	1	1	NUM
biomedich-811	166	14	,	,	PUNCT
biomedich-811	166	15	issue	issue	NOUN
biomedich-811	166	16	2	2	NUM
biomedich-811	166	17	)	)	PUNCT
biomedich-811	166	18	.	.	PUNCT
biomedich-811	167	1	manirakiza	manirakiza	PROPN
biomedich-811	167	2	,	,	PUNCT
biomedich-811	167	3	g.	g.	PROPN
biomedich-811	167	4	,	,	PUNCT
biomedich-811	167	5	kassaza	kassaza	PROPN
biomedich-811	167	6	,	,	PUNCT
biomedich-811	167	7	k.	k.	PROPN
biomedich-811	167	8	,	,	PUNCT
biomedich-811	167	9	taremwa	taremwa	PROPN
biomedich-811	167	10	,	,	PUNCT
biomedich-811	167	11	i.	i.	NOUN
biomedich-811	167	12	m.	m.	PROPN
biomedich-811	167	13	,	,	PUNCT
biomedich-811	167	14	bazira	bazira	PROPN
biomedich-811	167	15	,	,	PUNCT
biomedich-811	167	16	j.	j.	PROPN
biomedich-811	167	17	,	,	PUNCT
biomedich-811	167	18	&	&	CCONJ
biomedich-811	167	19	byarugaba	byarugaba	PROPN
biomedich-811	167	20	,	,	PUNCT
biomedich-811	167	21	f.	f.	PROPN
biomedich-811	167	22	(	(	PUNCT
biomedich-811	167	23	2022	2022	NUM
biomedich-811	167	24	)	)	PUNCT
biomedich-811	167	25	.	.	PUNCT
biomedich-811	168	1	molecular	molecular	ADJ
biomedich-811	168	2	identification	identification	NOUN
biomedich-811	168	3	and	and	CCONJ
biomedich-811	168	4	antimalarial	antimalarial	ADJ
biomedich-811	168	5	drug	drug	NOUN
biomedich-811	168	6	resistance	resistance	NOUN
biomedich-811	168	7	profile	profile	NOUN
biomedich-811	168	8	of	of	ADP
biomedich-811	168	9	plasmodium	plasmodium	NOUN
biomedich-811	168	10	falciparum	falciparum	NOUN
biomedich-811	168	11	from	from	ADP
biomedich-811	168	12	patients	patient	NOUN
biomedich-811	168	13	attending	attend	VERB
biomedich-811	168	14	kisoro	kisoro	PROPN
biomedich-811	168	15	hospital	hospital	NOUN
biomedich-811	168	16	,	,	PUNCT
biomedich-811	168	17	southwestern	southwestern	ADJ
biomedich-811	168	18	uganda	uganda	PROPN
biomedich-811	168	19	.	.	PUNCT
biomedich-811	169	1	malaria	malaria	PROPN
biomedich-811	169	2	journal	journal	PROPN
biomedich-811	169	3	,	,	PUNCT
biomedich-811	169	4	21(1	21(1	NUM
biomedich-811	169	5	)	)	PUNCT
biomedich-811	169	6	,	,	PUNCT
biomedich-811	169	7	1–10	1–10	NOUN
biomedich-811	169	8	.	.	PUNCT
biomedich-811	170	1	https://doi.org/10.1186/s12936021-04023-3	https://doi.org/10.1186/s12936021-04023-3	PROPN
biomedich-811	170	2	mungthin	mungthin	PROPN
biomedich-811	170	3	,	,	PUNCT
biomedich-811	170	4	m.	m.	NOUN
biomedich-811	170	5	,	,	PUNCT
biomedich-811	170	6	khositnithikul	khositnithikul	PROPN
biomedich-811	170	7	,	,	PUNCT
biomedich-811	170	8	r.	r.	PROPN
biomedich-811	170	9	,	,	PUNCT
biomedich-811	170	10	sitthichot	sitthichot	PROPN
biomedich-811	170	11	,	,	PUNCT
biomedich-811	170	12	n.	n.	NOUN
biomedich-811	170	13	,	,	PUNCT
biomedich-811	170	14	suwandittakul	suwandittakul	NOUN
biomedich-811	170	15	,	,	PUNCT
biomedich-811	170	16	n.	n.	NOUN
biomedich-811	170	17	,	,	PUNCT
biomedich-811	170	18	wattanaveeradej	wattanaveeradej	VERB
biomedich-811	170	19	,	,	PUNCT
biomedich-811	170	20	v.	v.	ADV
biomedich-811	170	21	,	,	PUNCT
biomedich-811	170	22	ward	ward	NOUN
biomedich-811	170	23	,	,	PUNCT
biomedich-811	170	24	s.	s.	PROPN
biomedich-811	170	25	a.	a.	PROPN
biomedich-811	170	26	,	,	PUNCT
biomedich-811	170	27	&	&	CCONJ
biomedich-811	170	28	na	na	NOUN
biomedich-811	170	29	-	-	PUNCT
biomedich-811	170	30	bangchang	bangchang	NOUN
biomedich-811	170	31	,	,	PUNCT
biomedich-811	170	32	k.	k.	PROPN
biomedich-811	170	33	(	(	PUNCT
biomedich-811	170	34	2010	2010	NUM
biomedich-811	170	35	)	)	PUNCT
biomedich-811	170	36	.	.	PUNCT
biomedich-811	171	1	association	association	NOUN
biomedich-811	171	2	between	between	ADP
biomedich-811	171	3	the	the	DET
biomedich-811	171	4	pfmdr1	pfmdr1	PROPN
biomedich-811	171	5	gene	gene	NOUN
biomedich-811	171	6	and	and	CCONJ
biomedich-811	171	7	in	in	ADP
biomedich-811	171	8	vitro	vitro	X
biomedich-811	171	9	artemether	artemether	ADJ
biomedich-811	171	10	and	and	CCONJ
biomedich-811	171	11	lumefantrine	lumefantrine	VERB
biomedich-811	171	12	sensitivity	sensitivity	NOUN
biomedich-811	171	13	in	in	ADP
biomedich-811	171	14	thai	thai	ADJ
biomedich-811	171	15	isolates	isolate	NOUN
biomedich-811	171	16	of	of	ADP
biomedich-811	171	17	plasmodium	plasmodium	NOUN
biomedich-811	171	18	falciparum	falciparum	NOUN
biomedich-811	171	19	.	.	PUNCT
biomedich-811	172	1	american	american	ADJ
biomedich-811	172	2	journal	journal	PROPN
biomedich-811	172	3	of	of	ADP
biomedich-811	172	4	tropical	tropical	ADJ
biomedich-811	172	5	medicine	medicine	NOUN
biomedich-811	172	6	and	and	CCONJ
biomedich-811	172	7	hygiene	hygiene	NOUN
biomedich-811	172	8	,	,	PUNCT
biomedich-811	172	9	83(5	83(5	NUM
biomedich-811	172	10	)	)	PUNCT
biomedich-811	172	11	,	,	PUNCT
biomedich-811	172	12	1005–1009	1005–1009	NUM
biomedich-811	172	13	.	.	PUNCT
biomedich-811	173	1	https://doi.org/10.4269/ajtmh.2010.10-0339	https://doi.org/10.4269/ajtmh.2010.10-0339	PROPN
biomedich-811	173	2	678	678	NUM
biomedich-811	173	3	biology	biology	NOUN
biomedich-811	173	4	,	,	PUNCT
biomedich-811	173	5	medicine	medicine	NOUN
biomedich-811	173	6	,	,	PUNCT
biomedich-811	173	7	&	&	CCONJ
biomedich-811	173	8	natural	natural	ADJ
biomedich-811	173	9	product	product	NOUN
biomedich-811	173	10	chemistry	chemistry	NOUN
biomedich-811	173	11	14	14	NUM
biomedich-811	173	12	(	(	PUNCT
biomedich-811	173	13	2	2	NUM
biomedich-811	173	14	)	)	PUNCT
biomedich-811	173	15	,	,	PUNCT
biomedich-811	173	16	2025	2025	NUM
biomedich-811	173	17	:	:	PUNCT
biomedich-811	173	18	673	673	NUM
biomedich-811	173	19	-	-	SYM
biomedich-811	173	20	678	678	NUM
biomedich-811	173	21	noreen	noreen	PROPN
biomedich-811	173	22	,	,	PUNCT
biomedich-811	173	23	n.	n.	PROPN
biomedich-811	173	24	,	,	PUNCT
biomedich-811	173	25	ullah	ullah	PROPN
biomedich-811	173	26	,	,	PUNCT
biomedich-811	173	27	a.	a.	PROPN
biomedich-811	173	28	,	,	PUNCT
biomedich-811	173	29	salman	salman	PROPN
biomedich-811	173	30	,	,	PUNCT
biomedich-811	173	31	s.	s.	PROPN
biomedich-811	173	32	m.	m.	PROPN
biomedich-811	173	33	,	,	PUNCT
biomedich-811	173	34	mabkhot	mabkhot	PROPN
biomedich-811	173	35	,	,	PUNCT
biomedich-811	173	36	y.	y.	PROPN
biomedich-811	173	37	,	,	PUNCT
biomedich-811	173	38	alsayari	alsayari	PROPN
biomedich-811	173	39	,	,	PUNCT
biomedich-811	173	40	a.	a.	PROPN
biomedich-811	173	41	,	,	PUNCT
biomedich-811	173	42	&	&	CCONJ
biomedich-811	173	43	badshah	badshah	PROPN
biomedich-811	173	44	,	,	PUNCT
biomedich-811	173	45	s.	s.	PROPN
biomedich-811	173	46	l.	l.	PROPN
biomedich-811	173	47	(	(	PUNCT
biomedich-811	173	48	2021	2021	NUM
biomedich-811	173	49	)	)	PUNCT
biomedich-811	173	50	.	.	PUNCT
biomedich-811	174	1	new	new	ADJ
biomedich-811	174	2	insights	insight	NOUN
biomedich-811	174	3	into	into	ADP
biomedich-811	174	4	the	the	DET
biomedich-811	174	5	spread	spread	NOUN
biomedich-811	174	6	of	of	ADP
biomedich-811	174	7	resistance	resistance	NOUN
biomedich-811	174	8	to	to	ADP
biomedich-811	174	9	artemisinin	artemisinin	PROPN
biomedich-811	174	10	and	and	CCONJ
biomedich-811	174	11	its	its	PRON
biomedich-811	174	12	analogues	analogue	NOUN
biomedich-811	174	13	.	.	PUNCT
biomedich-811	175	1	journal	journal	PROPN
biomedich-811	175	2	of	of	ADP
biomedich-811	175	3	global	global	ADJ
biomedich-811	175	4	antimicrobial	antimicrobial	ADJ
biomedich-811	175	5	resistance	resistance	NOUN
biomedich-811	175	6	,	,	PUNCT
biomedich-811	175	7	27	27	NUM
biomedich-811	175	8	,	,	PUNCT
biomedich-811	175	9	142–149	142–149	NUM
biomedich-811	175	10	.	.	PUNCT
biomedich-811	176	1	https://doi.org/10.1016/j.jgar.2021.09.001	https://doi.org/10.1016/j.jgar.2021.09.001	VERB
biomedich-811	176	2	nsanzabana	nsanzabana	PROPN
biomedich-811	176	3	,	,	PUNCT
biomedich-811	176	4	c.	c.	NOUN
biomedich-811	176	5	,	,	PUNCT
biomedich-811	176	6	djalle	djalle	PROPN
biomedich-811	176	7	,	,	PUNCT
biomedich-811	176	8	d.	d.	PROPN
biomedich-811	176	9	,	,	PUNCT
biomedich-811	176	10	guérin	guérin	PROPN
biomedich-811	176	11	,	,	PUNCT
biomedich-811	176	12	p.	p.	PROPN
biomedich-811	176	13	j.	j.	PROPN
biomedich-811	176	14	,	,	PUNCT
biomedich-811	176	15	ménard	ménard	PROPN
biomedich-811	176	16	,	,	PUNCT
biomedich-811	176	17	d.	d.	PROPN
biomedich-811	176	18	,	,	PUNCT
biomedich-811	176	19	&	&	CCONJ
biomedich-811	176	20	gonzález	gonzález	PROPN
biomedich-811	176	21	,	,	PUNCT
biomedich-811	176	22	i.	i.	PROPN
biomedich-811	176	23	j.	j.	PROPN
biomedich-811	176	24	(	(	PUNCT
biomedich-811	176	25	2018	2018	NUM
biomedich-811	176	26	)	)	PUNCT
biomedich-811	176	27	.	.	PUNCT
biomedich-811	177	1	tools	tool	NOUN
biomedich-811	177	2	for	for	ADP
biomedich-811	177	3	surveillance	surveillance	NOUN
biomedich-811	177	4	of	of	ADP
biomedich-811	177	5	antimalarial	antimalarial	ADJ
biomedich-811	177	6	drug	drug	NOUN
biomedich-811	177	7	resistance	resistance	NOUN
biomedich-811	177	8	:	:	PUNCT
biomedich-811	177	9	an	an	DET
biomedich-811	177	10	assessment	assessment	NOUN
biomedich-811	177	11	of	of	ADP
biomedich-811	177	12	the	the	DET
biomedich-811	177	13	current	current	ADJ
biomedich-811	177	14	landscape	landscape	NOUN
biomedich-811	177	15	.	.	PUNCT
biomedich-811	178	1	malaria	malaria	PROPN
biomedich-811	178	2	journal	journal	PROPN
biomedich-811	178	3	,	,	PUNCT
biomedich-811	178	4	17(1	17(1	NUM
biomedich-811	178	5	)	)	PUNCT
biomedich-811	178	6	,	,	PUNCT
biomedich-811	178	7	1–16	1–16	PROPN
biomedich-811	178	8	.	.	PUNCT
biomedich-811	179	1	https://doi.org/10.1186/s12936-0182185-9	https://doi.org/10.1186/s12936-0182185-9	PROPN
biomedich-811	179	2	price	price	NOUN
biomedich-811	179	3	,	,	PUNCT
biomedich-811	179	4	r.	r.	PROPN
biomedich-811	179	5	n.	n.	PROPN
biomedich-811	179	6	,	,	PUNCT
biomedich-811	179	7	uhlemann	uhlemann	PROPN
biomedich-811	179	8	,	,	PUNCT
biomedich-811	179	9	a.	a.	PROPN
biomedich-811	179	10	c.	c.	PROPN
biomedich-811	179	11	,	,	PUNCT
biomedich-811	179	12	brockman	brockman	PROPN
biomedich-811	179	13	,	,	PUNCT
biomedich-811	179	14	a.	a.	PROPN
biomedich-811	179	15	,	,	PUNCT
biomedich-811	179	16	mcgready	mcgready	PROPN
biomedich-811	179	17	,	,	PUNCT
biomedich-811	179	18	r.	r.	PROPN
biomedich-811	179	19	,	,	PUNCT
biomedich-811	179	20	ashley	ashley	PROPN
biomedich-811	179	21	,	,	PUNCT
biomedich-811	179	22	e.	e.	PROPN
biomedich-811	179	23	,	,	PUNCT
biomedich-811	179	24	phaipun	phaipun	PROPN
biomedich-811	179	25	,	,	PUNCT
biomedich-811	179	26	l.	l.	PROPN
biomedich-811	179	27	,	,	PUNCT
biomedich-811	179	28	patel	patel	PROPN
biomedich-811	179	29	,	,	PUNCT
biomedich-811	179	30	r.	r.	PROPN
biomedich-811	179	31	,	,	PUNCT
biomedich-811	179	32	laing	laing	PROPN
biomedich-811	179	33	,	,	PUNCT
biomedich-811	179	34	k.	k.	PROPN
biomedich-811	179	35	,	,	PUNCT
biomedich-811	179	36	looareesuwan	looareesuwan	PROPN
biomedich-811	179	37	,	,	PUNCT
biomedich-811	179	38	s.	s.	PROPN
biomedich-811	179	39	,	,	PUNCT
biomedich-811	179	40	white	white	ADJ
biomedich-811	179	41	,	,	PUNCT
biomedich-811	179	42	n.	n.	PROPN
biomedich-811	179	43	j.	j.	PROPN
biomedich-811	179	44	,	,	PUNCT
biomedich-811	179	45	nosten	nosten	PROPN
biomedich-811	179	46	,	,	PUNCT
biomedich-811	179	47	f.	f.	PROPN
biomedich-811	179	48	,	,	PUNCT
biomedich-811	179	49	&	&	CCONJ
biomedich-811	179	50	krishna	krishna	PROPN
biomedich-811	179	51	,	,	PUNCT
biomedich-811	179	52	s.	s.	PROPN
biomedich-811	179	53	(	(	PUNCT
biomedich-811	179	54	2004	2004	NUM
biomedich-811	179	55	)	)	PUNCT
biomedich-811	179	56	.	.	PUNCT
biomedich-811	180	1	mefloquine	mefloquine	NOUN
biomedich-811	180	2	resistance	resistance	NOUN
biomedich-811	180	3	in	in	ADP
biomedich-811	180	4	plasmodium	plasmodium	NOUN
biomedich-811	180	5	falciparum	falciparum	NOUN
biomedich-811	180	6	and	and	CCONJ
biomedich-811	180	7	increased	increase	VERB
biomedich-811	180	8	pfmdr1	pfmdr1	PROPN
biomedich-811	180	9	gene	gene	PROPN
biomedich-811	180	10	copy	copy	NOUN
biomedich-811	180	11	number	number	NOUN
biomedich-811	180	12	.	.	PUNCT
biomedich-811	181	1	lancet	lancet	NOUN
biomedich-811	181	2	,	,	PUNCT
biomedich-811	181	3	364(9432	364(9432	NOUN
biomedich-811	181	4	)	)	PUNCT
biomedich-811	181	5	,	,	PUNCT
biomedich-811	181	6	438–447	438–447	NUM
biomedich-811	181	7	.	.	PUNCT
biomedich-811	182	1	https://doi.org/10.1016/s0140-6736(04)16767-6	https://doi.org/10.1016/s0140-6736(04)16767-6	PROPN
biomedich-811	182	2	qiagen	qiagen	PROPN
biomedich-811	182	3	.	.	PUNCT
biomedich-811	183	1	(	(	PUNCT
biomedich-811	183	2	2007	2007	NUM
biomedich-811	183	3	)	)	PUNCT
biomedich-811	183	4	.	.	PUNCT
biomedich-811	184	1	qiaamp	qiaamp	PROPN
biomedich-811	184	2	®	®	PROPN
biomedich-811	184	3	dna	dna	PROPN
biomedich-811	184	4	mini	mini	NOUN
biomedich-811	184	5	and	and	CCONJ
biomedich-811	184	6	blood	blood	NOUN
biomedich-811	184	7	mini	mini	NOUN
biomedich-811	184	8	handbook	handbook	NOUN
biomedich-811	184	9	for	for	ADP
biomedich-811	184	10	dna	dna	PROPN
biomedich-811	184	11	purification	purification	NOUN
biomedich-811	184	12	.	.	PUNCT
biomedich-811	185	1	104(march	104(march	NUM
biomedich-811	185	2	)	)	PUNCT
biomedich-811	185	3	,	,	PUNCT
biomedich-811	186	1	101–108	101–108	NUM
biomedich-811	186	2	.	.	PUNCT
biomedich-811	187	1	http://www.ncbi.nlm.nih.gov/pubmed/16509153	http://www.ncbi.nlm.nih.gov/pubmed/16509153	VERB
biomedich-811	187	2	si	si	PROPN
biomedich-811	187	3	,	,	PUNCT
biomedich-811	187	4	k.	k.	PROPN
biomedich-811	187	5	,	,	PUNCT
biomedich-811	187	6	he	he	PRON
biomedich-811	187	7	,	,	PUNCT
biomedich-811	187	8	x.	x.	PROPN
biomedich-811	187	9	,	,	PUNCT
biomedich-811	187	10	chen	chen	PROPN
biomedich-811	187	11	,	,	PUNCT
biomedich-811	187	12	l.	l.	PROPN
biomedich-811	187	13	,	,	PUNCT
biomedich-811	187	14	zhang	zhang	PROPN
biomedich-811	187	15	,	,	PUNCT
biomedich-811	187	16	a.	a.	PROPN
biomedich-811	187	17	,	,	PUNCT
biomedich-811	187	18	guo	guo	PROPN
biomedich-811	187	19	,	,	PUNCT
biomedich-811	187	20	c.	c.	PROPN
biomedich-811	187	21	,	,	PUNCT
biomedich-811	187	22	&	&	CCONJ
biomedich-811	187	23	li	li	PROPN
biomedich-811	187	24	,	,	PUNCT
biomedich-811	187	25	m.	m.	NOUN
biomedich-811	187	26	(	(	PUNCT
biomedich-811	187	27	2023	2023	NUM
biomedich-811	187	28	)	)	PUNCT
biomedich-811	187	29	.	.	PUNCT
biomedich-811	188	1	the	the	DET
biomedich-811	188	2	structure	structure	NOUN
biomedich-811	188	3	of	of	ADP
biomedich-811	188	4	plasmodium	plasmodium	NOUN
biomedich-811	188	5	falciparum	falciparum	NOUN
biomedich-811	188	6	multidrug	multidrug	NOUN
biomedich-811	188	7	resistance	resistance	NOUN
biomedich-811	188	8	protein	protein	NOUN
biomedich-811	188	9	1	1	NUM
biomedich-811	188	10	reveals	reveal	VERB
biomedich-811	188	11	an	an	DET
biomedich-811	188	12	n	n	ADV
biomedich-811	188	13	-	-	PUNCT
biomedich-811	188	14	terminal	terminal	ADJ
biomedich-811	188	15	regulatory	regulatory	ADJ
biomedich-811	188	16	domain	domain	NOUN
biomedich-811	188	17	.	.	PUNCT
biomedich-811	189	1	proc	proc	PROPN
biomedich-811	189	2	natl	natl	PROPN
biomedich-811	189	3	acad	acad	PROPN
biomedich-811	189	4	sci	sci	PROPN
biomedich-811	189	5	u	u	PROPN
biomedich-811	189	6	s	s	PROPN
biomedich-811	189	7	a	a	PRON
biomedich-811	189	8	,	,	PUNCT
biomedich-811	189	9	120(32	120(32	NUM
biomedich-811	189	10	)	)	PUNCT
biomedich-811	189	11	,	,	PUNCT
biomedich-811	189	12	2023	2023	NUM
biomedich-811	189	13	.	.	PUNCT
biomedich-811	190	1	https://doi.org/10.1073/pnas	https://doi.org/10.1073/pnas	PROPN
biomedich-811	190	2	sisowath	sisowath	PROPN
biomedich-811	190	3	,	,	PUNCT
biomedich-811	190	4	c.	c.	PROPN
biomedich-811	190	5	,	,	PUNCT
biomedich-811	190	6	ferreira	ferreira	PROPN
biomedich-811	190	7	,	,	PUNCT
biomedich-811	190	8	p.	p.	PROPN
biomedich-811	190	9	e.	e.	PROPN
biomedich-811	190	10	,	,	PUNCT
biomedich-811	190	11	bustamante	bustamante	PROPN
biomedich-811	190	12	,	,	PUNCT
biomedich-811	190	13	l.	l.	PROPN
biomedich-811	190	14	y.	y.	PROPN
biomedich-811	190	15	,	,	PUNCT
biomedich-811	190	16	dahlström	dahlström	PROPN
biomedich-811	190	17	,	,	PUNCT
biomedich-811	190	18	s.	s.	PROPN
biomedich-811	190	19	,	,	PUNCT
biomedich-811	190	20	mårtensson	mårtensson	PROPN
biomedich-811	190	21	,	,	PUNCT
biomedich-811	190	22	a.	a.	NOUN
biomedich-811	190	23	,	,	PUNCT
biomedich-811	190	24	björkman	björkman	NOUN
biomedich-811	190	25	,	,	PUNCT
biomedich-811	190	26	a.	a.	NOUN
biomedich-811	190	27	,	,	PUNCT
biomedich-811	190	28	krishna	krishna	PROPN
biomedich-811	190	29	,	,	PUNCT
biomedich-811	190	30	s.	s.	PROPN
biomedich-811	190	31	,	,	PUNCT
biomedich-811	190	32	&	&	CCONJ
biomedich-811	190	33	gil	gil	PROPN
biomedich-811	190	34	,	,	PUNCT
biomedich-811	190	35	j.	j.	PROPN
biomedich-811	190	36	p.	p.	PROPN
biomedich-811	190	37	(	(	PUNCT
biomedich-811	190	38	2007	2007	NUM
biomedich-811	190	39	)	)	PUNCT
biomedich-811	190	40	.	.	PUNCT
biomedich-811	191	1	the	the	DET
biomedich-811	191	2	role	role	NOUN
biomedich-811	191	3	of	of	ADP
biomedich-811	191	4	pfmdr1	pfmdr1	PROPN
biomedich-811	191	5	in	in	ADP
biomedich-811	191	6	plasmodium	plasmodium	NOUN
biomedich-811	191	7	falciparum	falciparum	ADJ
biomedich-811	191	8	tolerance	tolerance	NOUN
biomedich-811	191	9	to	to	ADP
biomedich-811	191	10	artemether	artemether	ADJ
biomedich-811	191	11	-	-	PUNCT
biomedich-811	191	12	lumefantrine	lumefantrine	NOUN
biomedich-811	191	13	in	in	ADP
biomedich-811	191	14	africa	africa	PROPN
biomedich-811	191	15	.	.	PUNCT
biomedich-811	192	1	tropical	tropical	ADJ
biomedich-811	192	2	medicine	medicine	NOUN
biomedich-811	192	3	and	and	CCONJ
biomedich-811	192	4	international	international	ADJ
biomedich-811	192	5	health	health	NOUN
biomedich-811	192	6	,	,	PUNCT
biomedich-811	192	7	12(6	12(6	NUM
biomedich-811	192	8	)	)	PUNCT
biomedich-811	192	9	,	,	PUNCT
biomedich-811	192	10	736–742	736–742	NUM
biomedich-811	192	11	.	.	PUNCT
biomedich-811	193	1	https://doi.org/10.1111/j.1365-3156.2007.01843.x	https://doi.org/10.1111/j.1365-3156.2007.01843.x	PROPN
biomedich-811	193	2	veiga	veiga	PROPN
biomedich-811	193	3	,	,	PUNCT
biomedich-811	193	4	m.	m.	NOUN
biomedich-811	193	5	i.	i.	PROPN
biomedich-811	193	6	,	,	PUNCT
biomedich-811	193	7	dhingra	dhingra	PROPN
biomedich-811	193	8	,	,	PUNCT
biomedich-811	193	9	s.	s.	PROPN
biomedich-811	193	10	k.	k.	PROPN
biomedich-811	193	11	,	,	PUNCT
biomedich-811	193	12	henrich	henrich	ADV
biomedich-811	193	13	,	,	PUNCT
biomedich-811	193	14	p.	p.	PROPN
biomedich-811	193	15	p.	p.	PROPN
biomedich-811	193	16	,	,	PUNCT
biomedich-811	193	17	straimer	straimer	PROPN
biomedich-811	193	18	,	,	PUNCT
biomedich-811	193	19	j.	j.	PROPN
biomedich-811	193	20	,	,	PUNCT
biomedich-811	193	21	gnädig	gnädig	PROPN
biomedich-811	193	22	,	,	PUNCT
biomedich-811	193	23	n.	n.	NOUN
biomedich-811	193	24	,	,	PUNCT
biomedich-811	193	25	uhlemann	uhlemann	PROPN
biomedich-811	193	26	,	,	PUNCT
biomedich-811	193	27	a.	a.	PROPN
biomedich-811	193	28	c.	c.	PROPN
biomedich-811	193	29	,	,	PUNCT
biomedich-811	193	30	martin	martin	PROPN
biomedich-811	193	31	,	,	PUNCT
biomedich-811	193	32	r.	r.	PROPN
biomedich-811	193	33	e.	e.	PROPN
biomedich-811	193	34	,	,	PUNCT
biomedich-811	193	35	lehane	lehane	PROPN
biomedich-811	193	36	,	,	PUNCT
biomedich-811	193	37	a.	a.	NOUN
biomedich-811	193	38	m.	m.	NOUN
biomedich-811	193	39	,	,	PUNCT
biomedich-811	193	40	&	&	CCONJ
biomedich-811	193	41	fidock	fidock	PROPN
biomedich-811	193	42	,	,	PUNCT
biomedich-811	193	43	d.	d.	PROPN
biomedich-811	193	44	a.	a.	PROPN
biomedich-811	193	45	(	(	PUNCT
biomedich-811	193	46	2016	2016	NUM
biomedich-811	193	47	)	)	PUNCT
biomedich-811	193	48	.	.	PUNCT
biomedich-811	194	1	globally	globally	ADV
biomedich-811	194	2	prevalent	prevalent	ADJ
biomedich-811	194	3	pfmdr1	pfmdr1	PROPN
biomedich-811	194	4	mutations	mutation	NOUN
biomedich-811	194	5	modulate	modulate	VERB
biomedich-811	194	6	plasmodium	plasmodium	NOUN
biomedich-811	194	7	falciparum	falciparum	ADJ
biomedich-811	194	8	susceptibility	susceptibility	NOUN
biomedich-811	194	9	to	to	ADP
biomedich-811	194	10	artemisinin	artemisinin	NOUN
biomedich-811	194	11	-	-	PUNCT
biomedich-811	194	12	based	base	VERB
biomedich-811	194	13	combination	combination	NOUN
biomedich-811	194	14	therapies	therapy	NOUN
biomedich-811	194	15	.	.	PUNCT
biomedich-811	195	1	nature	nature	NOUN
biomedich-811	195	2	communications	communication	NOUN
biomedich-811	195	3	,	,	PUNCT
biomedich-811	195	4	7(may	7(may	NUM
biomedich-811	195	5	)	)	PUNCT
biomedich-811	195	6	.	.	PUNCT
biomedich-811	196	1	https://doi.org/10.1038/ncomms11553	https://doi.org/10.1038/ncomms11553	NOUN
biomedich-811	196	2	who	who	PRON
biomedich-811	196	3	.	.	PUNCT
biomedich-811	197	1	(	(	PUNCT
biomedich-811	197	2	2014	2014	NUM
biomedich-811	197	3	)	)	PUNCT
biomedich-811	197	4	.	.	PUNCT
biomedich-811	198	1	severe	severe	ADJ
biomedich-811	198	2	malaria	malaria	NOUN
biomedich-811	198	3	.	.	PUNCT
biomedich-811	199	1	trop	trop	X
biomedich-811	199	2	med	med	ADJ
biomedich-811	199	3	int	int	PROPN
biomedich-811	199	4	health	health	NOUN
biomedich-811	199	5	,	,	PUNCT
biomedich-811	199	6	19(suppl	19(suppl	NUM
biomedich-811	199	7	i	i	NOUN
biomedich-811	199	8	)	)	PUNCT
biomedich-811	199	9	,	,	PUNCT
biomedich-811	199	10	7–131	7–131	X
biomedich-811	199	11	.	.	PUNCT
biomedich-811	200	1	who	who	PRON
biomedich-811	200	2	.	.	PUNCT
biomedich-811	201	1	(	(	PUNCT
biomedich-811	201	2	2023	2023	NUM
biomedich-811	201	3	)	)	PUNCT
biomedich-811	201	4	.	.	PUNCT
biomedich-811	202	1	world	world	NOUN
biomedich-811	202	2	malaria	malaria	PROPN
biomedich-811	202	3	report	report	NOUN
biomedich-811	202	4	2023	2023	NUM
biomedich-811	202	5	.	.	PUNCT
biomedich-811	203	1	world	world	NOUN
biomedich-811	203	2	health	health	PROPN
biomedich-811	203	3	organization	organization	PROPN
biomedich-811	203	4	.	.	PUNCT
biomedich-811	204	1	who	who	PRON
biomedich-811	204	2	,	,	PUNCT
biomedich-811	204	3	w.	w.	PROPN
biomedich-811	204	4	h.	h.	PROPN
biomedich-811	204	5	o.	o.	PROPN
biomedich-811	204	6	(	(	PUNCT
biomedich-811	204	7	2022	2022	NUM
biomedich-811	204	8	)	)	PUNCT
biomedich-811	204	9	.	.	PUNCT
biomedich-811	205	1	strategy	strategy	NOUN
biomedich-811	205	2	to	to	PART
biomedich-811	205	3	respond	respond	VERB
biomedich-811	205	4	to	to	ADP
biomedich-811	205	5	antimalarial	antimalarial	ADJ
biomedich-811	205	6	drug	drug	NOUN
biomedich-811	205	7	resistance	resistance	NOUN
biomedich-811	205	8	in	in	ADP
biomedich-811	205	9	africa	africa	PROPN
biomedich-811	205	10	.	.	PUNCT
biomedich-811	206	1	in	in	ADP
biomedich-811	206	2	world	world	PROPN
biomedich-811	206	3	health	health	NOUN
biomedich-811	206	4	organization	organization	NOUN
biomedich-811	206	5	(	(	PUNCT
biomedich-811	206	6	vol	vol	NOUN
biomedich-811	206	7	.	.	NOUN
biomedich-811	206	8	1	1	NUM
biomedich-811	206	9	)	)	PUNCT
biomedich-811	206	10	.	.	PUNCT
biomedich-811	207	1	who	who	PRON
biomedich-811	207	2	,	,	PUNCT
biomedich-811	207	3	w.	w.	PROPN
biomedich-811	207	4	h.	h.	PROPN
biomedich-811	207	5	o.	o.	PROPN
biomedich-811	207	6	(	(	PUNCT
biomedich-811	207	7	2024	2024	NUM
biomedich-811	207	8	)	)	PUNCT
biomedich-811	207	9	.	.	PUNCT
biomedich-811	208	1	who	who	PRON
biomedich-811	208	2	guidelines	guideline	VERB
biomedich-811	208	3	for	for	ADP
biomedich-811	208	4	malaria	malaria	NOUN
biomedich-811	208	5	.	.	PUNCT
biomedich-811	209	1	who	who	PRON
biomedich-811	209	2	,	,	PUNCT
biomedich-811	209	3	november	november	PROPN
biomedich-811	209	4	,	,	PUNCT
biomedich-811	209	5	210	210	NUM
biomedich-811	209	6	.	.	PUNCT
biomedich-811	209	7	wurtz	wurtz	PROPN
biomedich-811	209	8	,	,	PUNCT
biomedich-811	209	9	n.	n.	NOUN
biomedich-811	209	10	,	,	PUNCT
biomedich-811	209	11	fall	fall	NOUN
biomedich-811	209	12	,	,	PUNCT
biomedich-811	209	13	b.	b.	PROPN
biomedich-811	209	14	,	,	PUNCT
biomedich-811	209	15	pascual	pascual	PROPN
biomedich-811	209	16	,	,	PUNCT
biomedich-811	209	17	a.	a.	NOUN
biomedich-811	209	18	,	,	PUNCT
biomedich-811	209	19	fall	fall	NOUN
biomedich-811	209	20	,	,	PUNCT
biomedich-811	209	21	m.	m.	NOUN
biomedich-811	209	22	,	,	PUNCT
biomedich-811	209	23	baret	baret	PROPN
biomedich-811	209	24	,	,	PUNCT
biomedich-811	209	25	e.	e.	PROPN
biomedich-811	209	26	,	,	PUNCT
biomedich-811	209	27	camara	camara	PROPN
biomedich-811	209	28	,	,	PUNCT
biomedich-811	209	29	c.	c.	PROPN
biomedich-811	209	30	,	,	PUNCT
biomedich-811	209	31	nakoulima	nakoulima	PROPN
biomedich-811	209	32	,	,	PUNCT
biomedich-811	209	33	a.	a.	PROPN
biomedich-811	209	34	,	,	PUNCT
biomedich-811	209	35	diatta	diatta	NOUN
biomedich-811	209	36	,	,	PUNCT
biomedich-811	209	37	b.	b.	PROPN
biomedich-811	209	38	,	,	PUNCT
biomedich-811	209	39	fall	fall	PROPN
biomedich-811	209	40	,	,	PUNCT
biomedich-811	209	41	k.	k.	PROPN
biomedich-811	209	42	b.	b.	PROPN
biomedich-811	209	43	,	,	PUNCT
biomedich-811	209	44	mbaye	mbaye	NOUN
biomedich-811	209	45	,	,	PUNCT
biomedich-811	209	46	p.	p.	PROPN
biomedich-811	209	47	s.	s.	PROPN
biomedich-811	209	48	,	,	PUNCT
biomedich-811	209	49	diémé	diémé	NOUN
biomedich-811	209	50	,	,	PUNCT
biomedich-811	209	51	y.	y.	PROPN
biomedich-811	209	52	,	,	PUNCT
biomedich-811	209	53	bercion	bercion	PROPN
biomedich-811	209	54	,	,	PUNCT
biomedich-811	209	55	r.	r.	PROPN
biomedich-811	209	56	,	,	PUNCT
biomedich-811	209	57	wade	wade	PROPN
biomedich-811	209	58	,	,	PUNCT
biomedich-811	209	59	b.	b.	PROPN
biomedich-811	209	60	,	,	PUNCT
biomedich-811	209	61	&	&	CCONJ
biomedich-811	209	62	pradines	pradine	NOUN
biomedich-811	209	63	,	,	PUNCT
biomedich-811	209	64	b.	b.	PROPN
biomedich-811	209	65	(	(	PUNCT
biomedich-811	209	66	2014	2014	NUM
biomedich-811	209	67	)	)	PUNCT
biomedich-811	209	68	.	.	PUNCT
biomedich-811	210	1	role	role	NOUN
biomedich-811	210	2	of	of	ADP
biomedich-811	210	3	pfmdr1	pfmdr1	PROPN
biomedich-811	210	4	in	in	ADP
biomedich-811	210	5	in	in	ADP
biomedich-811	210	6	vitro	vitro	X
biomedich-811	210	7	plasmodium	plasmodium	NOUN
biomedich-811	210	8	falciparum	falciparum	ADJ
biomedich-811	210	9	susceptibility	susceptibility	NOUN
biomedich-811	210	10	to	to	AUX
biomedich-811	210	11	chloroquine	chloroquine	NOUN
biomedich-811	210	12	,	,	PUNCT
biomedich-811	210	13	quinine	quinine	NOUN
biomedich-811	210	14	,	,	PUNCT
biomedich-811	210	15	monodesethylamodiaquine	monodesethylamodiaquine	NOUN
biomedich-811	210	16	,	,	PUNCT
biomedich-811	210	17	mefloquine	mefloquine	NOUN
biomedich-811	210	18	,	,	PUNCT
biomedich-811	210	19	lumefantrine	lumefantrine	ADJ
biomedich-811	210	20	,	,	PUNCT
biomedich-811	210	21	and	and	CCONJ
biomedich-811	210	22	dihydroartemisinin	dihydroartemisinin	NOUN
biomedich-811	210	23	.	.	PUNCT
biomedich-811	211	1	antimicrobial	antimicrobial	ADJ
biomedich-811	211	2	agents	agent	NOUN
biomedich-811	211	3	and	and	CCONJ
biomedich-811	211	4	chemotherapy	chemotherapy	NOUN
biomedich-811	211	5	,	,	PUNCT
biomedich-811	211	6	58(12	58(12	NUM
biomedich-811	211	7	)	)	PUNCT
biomedich-811	211	8	,	,	PUNCT
biomedich-811	211	9	7032–7040	7032–7040	NUM
biomedich-811	211	10	.	.	PUNCT
biomedich-811	212	1	https://doi.org/10.1128/aac.03494-14	https://doi.org/10.1128/aac.03494-14	PROPN
biomedich-811	212	2	xu	xu	PROPN
biomedich-811	212	3	,	,	PUNCT
biomedich-811	212	4	c.	c.	PROPN
biomedich-811	212	5	,	,	PUNCT
biomedich-811	212	6	wei	wei	PROPN
biomedich-811	212	7	,	,	PUNCT
biomedich-811	212	8	q.	q.	PROPN
biomedich-811	212	9	,	,	PUNCT
biomedich-811	212	10	yin	yin	PROPN
biomedich-811	212	11	,	,	PUNCT
biomedich-811	212	12	k.	k.	PROPN
biomedich-811	212	13	,	,	PUNCT
biomedich-811	212	14	sun	sun	PROPN
biomedich-811	212	15	,	,	PUNCT
biomedich-811	212	16	h.	h.	PROPN
biomedich-811	212	17	,	,	PUNCT
biomedich-811	212	18	li	li	PROPN
biomedich-811	212	19	,	,	PUNCT
biomedich-811	212	20	j.	j.	PROPN
biomedich-811	212	21	,	,	PUNCT
biomedich-811	212	22	xiao	xiao	PROPN
biomedich-811	212	23	,	,	PUNCT
biomedich-811	212	24	t.	t.	PROPN
biomedich-811	212	25	,	,	PUNCT
biomedich-811	212	26	kong	kong	PROPN
biomedich-811	212	27	,	,	PUNCT
biomedich-811	212	28	x.	x.	PROPN
biomedich-811	212	29	,	,	PUNCT
biomedich-811	212	30	wang	wang	PROPN
biomedich-811	212	31	,	,	PUNCT
biomedich-811	212	32	y.	y.	PROPN
biomedich-811	212	33	,	,	PUNCT
biomedich-811	212	34	zhao	zhao	PROPN
biomedich-811	212	35	,	,	PUNCT
biomedich-811	212	36	g.	g.	PROPN
biomedich-811	212	37	,	,	PUNCT
biomedich-811	212	38	zhu	zhu	PROPN
biomedich-811	212	39	,	,	PUNCT
biomedich-811	212	40	s.	s.	PROPN
biomedich-811	212	41	,	,	PUNCT
biomedich-811	212	42	kou	kou	PROPN
biomedich-811	212	43	,	,	PUNCT
biomedich-811	212	44	j.	j.	PROPN
biomedich-811	212	45	,	,	PUNCT
biomedich-811	212	46	yan	yan	PROPN
biomedich-811	212	47	,	,	PUNCT
biomedich-811	212	48	g.	g.	PROPN
biomedich-811	212	49	,	,	PUNCT
biomedich-811	212	50	&	&	CCONJ
biomedich-811	212	51	huang	huang	PROPN
biomedich-811	212	52	,	,	PUNCT
biomedich-811	212	53	b.	b.	PROPN
biomedich-811	212	54	(	(	PUNCT
biomedich-811	212	55	2018	2018	NUM
biomedich-811	212	56	)	)	PUNCT
biomedich-811	212	57	.	.	PUNCT
biomedich-811	213	1	surveillance	surveillance	NOUN
biomedich-811	213	2	of	of	ADP
biomedich-811	213	3	antimalarial	antimalarial	ADJ
biomedich-811	213	4	resistance	resistance	NOUN
biomedich-811	213	5	pfcrt	pfcrt	NOUN
biomedich-811	213	6	,	,	PUNCT
biomedich-811	213	7	pfmdr1	pfmdr1	PROPN
biomedich-811	213	8	,	,	PUNCT
biomedich-811	213	9	and	and	CCONJ
biomedich-811	213	10	pfkelch13	pfkelch13	ADJ
biomedich-811	213	11	polymorphisms	polymorphism	NOUN
biomedich-811	213	12	in	in	ADP
biomedich-811	213	13	african	african	ADJ
biomedich-811	213	14	plasmodium	plasmodium	NOUN
biomedich-811	213	15	falciparum	falciparum	NOUN
biomedich-811	213	16	imported	import	VERB
biomedich-811	213	17	to	to	ADP
biomedich-811	213	18	shandong	shandong	PROPN
biomedich-811	213	19	province	province	PROPN
biomedich-811	213	20	,	,	PUNCT
biomedich-811	213	21	china	china	PROPN
biomedich-811	213	22	.	.	PUNCT
biomedich-811	214	1	scientific	scientific	ADJ
biomedich-811	214	2	reports	report	NOUN
biomedich-811	214	3	,	,	PUNCT
biomedich-811	214	4	8(1	8(1	NOUN
biomedich-811	214	5	)	)	PUNCT
biomedich-811	214	6	,	,	PUNCT
biomedich-811	214	7	1–9	1–9	NOUN
biomedich-811	214	8	.	.	PUNCT
biomedich-811	215	1	https://doi.org/10.1038/s41598-018-31207w	https://doi.org/10.1038/s41598-018-31207w	PROPN