id	sid	tid	token	lemma	pos
biomedich-816	1	1	biology	biology	NOUN
biomedich-816	1	2	,	,	PUNCT
biomedich-816	1	3	medicine	medicine	NOUN
biomedich-816	1	4	,	,	PUNCT
biomedich-816	1	5	&	&	CCONJ
biomedich-816	1	6	natural	natural	ADJ
biomedich-816	1	7	product	product	NOUN
biomedich-816	1	8	chemistry	chemistry	NOUN
biomedich-816	1	9	issn	issn	VERB
biomedich-816	1	10	2089	2089	NUM
biomedich-816	1	11	-	-	SYM
biomedich-816	1	12	6514	6514	NUM
biomedich-816	1	13	(	(	PUNCT
biomedich-816	1	14	paper	paper	NOUN
biomedich-816	1	15	)	)	PUNCT
biomedich-816	1	16	volume	volume	NOUN
biomedich-816	1	17	14	14	NUM
biomedich-816	1	18	,	,	PUNCT
biomedich-816	1	19	number	number	NOUN
biomedich-816	1	20	2	2	NUM
biomedich-816	1	21	,	,	PUNCT
biomedich-816	1	22	october	october	PROPN
biomedich-816	1	23	2025	2025	NUM
biomedich-816	1	24	|	|	ADV
biomedich-816	1	25	pages	page	NOUN
biomedich-816	1	26	:	:	PUNCT
biomedich-816	1	27	717	717	NUM
biomedich-816	1	28	-	-	SYM
biomedich-816	1	29	723	723	NUM
biomedich-816	1	30	|	|	ADV
biomedich-816	1	31	doi	doi	NOUN
biomedich-816	1	32	:	:	PUNCT
biomedich-816	1	33	10.14421	10.14421	NUM
biomedich-816	1	34	/	/	SYM
biomedich-816	1	35	biomedich.2025.142.717	biomedich.2025.142.717	PROPN
biomedich-816	1	36	-	-	PUNCT
biomedich-816	1	37	723	723	NUM
biomedich-816	1	38	issn	issn	PROPN
biomedich-816	1	39	2540	2540	NUM
biomedich-816	1	40	-	-	SYM
biomedich-816	1	41	9328	9328	NUM
biomedich-816	1	42	(	(	PUNCT
biomedich-816	1	43	online	online	ADV
biomedich-816	1	44	)	)	PUNCT
biomedich-816	1	45	investigating	investigate	VERB
biomedich-816	1	46	genetic	genetic	ADJ
biomedich-816	1	47	vulnerability	vulnerability	NOUN
biomedich-816	1	48	to	to	ADP
biomedich-816	1	49	environmental	environmental	ADJ
biomedich-816	1	50	exposures	exposure	NOUN
biomedich-816	1	51	and	and	CCONJ
biomedich-816	1	52	associated	associated	ADJ
biomedich-816	1	53	lung	lung	NOUN
biomedich-816	1	54	diseases	disease	NOUN
biomedich-816	1	55	:	:	PUNCT
biomedich-816	1	56	a	a	DET
biomedich-816	1	57	bioinformatics	bioinformatics	NOUN
biomedich-816	1	58	study	study	NOUN
biomedich-816	1	59	muhammad	muhammad	PROPN
biomedich-816	1	60	farid	farid	PROPN
biomedich-816	1	61	*	*	PROPN
biomedich-816	1	62	,	,	PUNCT
biomedich-816	1	63	ardestya	ardestya	ADJ
biomedich-816	1	64	rastrani	rastrani	NOUN
biomedich-816	1	65	,	,	PUNCT
biomedich-816	1	66	shaldhan	shaldhan	PROPN
biomedich-816	1	67	bayu	bayu	VERB
biomedich-816	1	68	yuska	yuska	ADJ
biomedich-816	1	69	faculty	faculty	NOUN
biomedich-816	1	70	of	of	ADP
biomedich-816	1	71	medicine	medicine	NOUN
biomedich-816	1	72	,	,	PUNCT
biomedich-816	1	73	universitas	universita	NOUN
biomedich-816	1	74	ahmad	ahmad	PROPN
biomedich-816	1	75	dahlan	dahlan	PROPN
biomedich-816	1	76	,	,	PUNCT
biomedich-816	1	77	jl	jl	PROPN
biomedich-816	1	78	.	.	PUNCT
biomedich-816	2	1	ahmad	ahmad	PROPN
biomedich-816	2	2	dahlan	dahlan	PROPN
biomedich-816	2	3	university	university	NOUN
biomedich-816	2	4	campus	campus	NOUN
biomedich-816	2	5	4	4	NUM
biomedich-816	2	6	,	,	PUNCT
biomedich-816	2	7	kragilan	kragilan	ADJ
biomedich-816	2	8	,	,	PUNCT
biomedich-816	2	9	tamanan	tamanan	ADJ
biomedich-816	2	10	,	,	PUNCT
biomedich-816	2	11	banguntapan	banguntapan	NOUN
biomedich-816	2	12	district	district	PROPN
biomedich-816	2	13	,	,	PUNCT
biomedich-816	2	14	bantul	bantul	NOUN
biomedich-816	2	15	regency	regency	PROPN
biomedich-816	2	16	,	,	PUNCT
biomedich-816	2	17	special	special	ADJ
biomedich-816	2	18	region	region	NOUN
biomedich-816	2	19	of	of	ADP
biomedich-816	2	20	yogyakarta	yogyakarta	PROPN
biomedich-816	2	21	,	,	PUNCT
biomedich-816	2	22	5519	5519	NUM
biomedich-816	2	23	,	,	PUNCT
biomedich-816	2	24	indonesia	indonesia	PROPN
biomedich-816	2	25	.	.	PUNCT
biomedich-816	3	1	corresponding	correspond	VERB
biomedich-816	3	2	author	author	PROPN
biomedich-816	3	3	*	*	PROPN
biomedich-816	3	4	muhammad2100034023@webmail.uad.ac.id	muhammad2100034023@webmail.uad.ac.id	PROPN
biomedich-816	3	5	manuscript	manuscript	NOUN
biomedich-816	3	6	received	receive	VERB
biomedich-816	3	7	:	:	PUNCT
biomedich-816	3	8	04	04	NUM
biomedich-816	3	9	june	june	PROPN
biomedich-816	3	10	,	,	PUNCT
biomedich-816	3	11	2025	2025	NUM
biomedich-816	3	12	.	.	PUNCT
biomedich-816	4	1	revision	revision	NOUN
biomedich-816	4	2	accepted	accept	VERB
biomedich-816	4	3	:	:	PUNCT
biomedich-816	4	4	18	18	NUM
biomedich-816	4	5	september	september	PROPN
biomedich-816	4	6	,	,	PUNCT
biomedich-816	4	7	2025	2025	NUM
biomedich-816	4	8	.	.	PUNCT
biomedich-816	5	1	published	publish	VERB
biomedich-816	5	2	:	:	PUNCT
biomedich-816	5	3	01	01	NUM
biomedich-816	5	4	october	october	PROPN
biomedich-816	5	5	,	,	PUNCT
biomedich-816	5	6	2025	2025	NUM
biomedich-816	5	7	.	.	PUNCT
biomedich-816	6	1	abstract	abstract	ADJ
biomedich-816	6	2	lung	lung	NOUN
biomedich-816	6	3	diseases	disease	NOUN
biomedich-816	6	4	induced	induce	VERB
biomedich-816	6	5	by	by	ADP
biomedich-816	6	6	environmental	environmental	ADJ
biomedich-816	6	7	exposures	exposure	NOUN
biomedich-816	6	8	such	such	ADJ
biomedich-816	6	9	as	as	ADP
biomedich-816	6	10	air	air	NOUN
biomedich-816	6	11	pollution	pollution	NOUN
biomedich-816	6	12	,	,	PUNCT
biomedich-816	6	13	cigarette	cigarette	NOUN
biomedich-816	6	14	smoke	smoke	NOUN
biomedich-816	6	15	,	,	PUNCT
biomedich-816	6	16	and	and	CCONJ
biomedich-816	6	17	industrial	industrial	ADJ
biomedich-816	6	18	particles	particle	NOUN
biomedich-816	6	19	remain	remain	VERB
biomedich-816	6	20	a	a	DET
biomedich-816	6	21	significant	significant	ADJ
biomedich-816	6	22	global	global	ADJ
biomedich-816	6	23	health	health	NOUN
biomedich-816	6	24	concern	concern	NOUN
biomedich-816	6	25	,	,	PUNCT
biomedich-816	6	26	contributing	contribute	VERB
biomedich-816	6	27	to	to	ADP
biomedich-816	6	28	high	high	ADJ
biomedich-816	6	29	morbidity	morbidity	NOUN
biomedich-816	6	30	and	and	CCONJ
biomedich-816	6	31	mortality	mortality	NOUN
biomedich-816	6	32	rates	rate	NOUN
biomedich-816	6	33	.	.	PUNCT
biomedich-816	7	1	genetic	genetic	ADJ
biomedich-816	7	2	variations	variation	NOUN
biomedich-816	7	3	are	be	AUX
biomedich-816	7	4	known	know	VERB
biomedich-816	7	5	to	to	PART
biomedich-816	7	6	influence	influence	VERB
biomedich-816	7	7	individual	individual	ADJ
biomedich-816	7	8	responses	response	NOUN
biomedich-816	7	9	to	to	ADP
biomedich-816	7	10	environmental	environmental	ADJ
biomedich-816	7	11	exposures	exposure	NOUN
biomedich-816	7	12	,	,	PUNCT
biomedich-816	7	13	but	but	CCONJ
biomedich-816	7	14	the	the	DET
biomedich-816	7	15	molecular	molecular	ADJ
biomedich-816	7	16	mechanisms	mechanism	NOUN
biomedich-816	7	17	underlying	underlie	VERB
biomedich-816	7	18	these	these	DET
biomedich-816	7	19	interactions	interaction	NOUN
biomedich-816	7	20	are	be	AUX
biomedich-816	7	21	not	not	PART
biomedich-816	7	22	well	well	ADV
biomedich-816	7	23	understood	understand	VERB
biomedich-816	7	24	.	.	PUNCT
biomedich-816	8	1	this	this	DET
biomedich-816	8	2	study	study	NOUN
biomedich-816	8	3	aims	aim	VERB
biomedich-816	8	4	to	to	PART
biomedich-816	8	5	identify	identify	VERB
biomedich-816	8	6	genetic	genetic	ADJ
biomedich-816	8	7	variants	variant	NOUN
biomedich-816	8	8	,	,	PUNCT
biomedich-816	8	9	specifically	specifically	ADV
biomedich-816	8	10	single	single	ADJ
biomedich-816	8	11	nucleotide	nucleotide	ADJ
biomedich-816	8	12	polymorphisms	polymorphism	NOUN
biomedich-816	8	13	(	(	PUNCT
biomedich-816	8	14	snps	snps	PROPN
biomedich-816	8	15	)	)	PUNCT
biomedich-816	8	16	,	,	PUNCT
biomedich-816	8	17	that	that	PRON
biomedich-816	8	18	may	may	AUX
biomedich-816	8	19	increase	increase	VERB
biomedich-816	8	20	the	the	DET
biomedich-816	8	21	risk	risk	NOUN
biomedich-816	8	22	of	of	ADP
biomedich-816	8	23	lung	lung	NOUN
biomedich-816	8	24	diseases	disease	NOUN
biomedich-816	8	25	using	use	VERB
biomedich-816	8	26	a	a	DET
biomedich-816	8	27	bioinformatics	bioinformatics	NOUN
biomedich-816	8	28	approach	approach	NOUN
biomedich-816	8	29	.	.	PUNCT
biomedich-816	9	1	the	the	DET
biomedich-816	9	2	analysis	analysis	NOUN
biomedich-816	9	3	was	be	AUX
biomedich-816	9	4	conducted	conduct	VERB
biomedich-816	9	5	by	by	ADP
biomedich-816	9	6	integrating	integrate	VERB
biomedich-816	9	7	various	various	ADJ
biomedich-816	9	8	public	public	ADJ
biomedich-816	9	9	genetic	genetic	ADJ
biomedich-816	9	10	databases	database	NOUN
biomedich-816	9	11	,	,	PUNCT
biomedich-816	9	12	including	include	VERB
biomedich-816	9	13	phewas	phewas	PROPN
biomedich-816	9	14	,	,	PUNCT
biomedich-816	9	15	gwas	gwas	PROPN
biomedich-816	9	16	catalog	catalog	NOUN
biomedich-816	9	17	,	,	PUNCT
biomedich-816	9	18	haploreg	haploreg	NOUN
biomedich-816	9	19	v4.2	v4.2	NOUN
biomedich-816	9	20	,	,	PUNCT
biomedich-816	9	21	gtex	gtex	PROPN
biomedich-816	9	22	portal	portal	NOUN
biomedich-816	9	23	,	,	PUNCT
biomedich-816	9	24	and	and	CCONJ
biomedich-816	9	25	ensembl	ensembl	PROPN
biomedich-816	9	26	genome	genome	NOUN
biomedich-816	9	27	browser	browser	NOUN
biomedich-816	9	28	.	.	PUNCT
biomedich-816	10	1	snps	snps	PROPN
biomedich-816	10	2	were	be	AUX
biomedich-816	10	3	filtered	filter	VERB
biomedich-816	10	4	based	base	VERB
biomedich-816	10	5	on	on	ADP
biomedich-816	10	6	p	p	NOUN
biomedich-816	10	7	-	-	PUNCT
biomedich-816	10	8	value	value	NOUN
biomedich-816	10	9	<	<	NOUN
biomedich-816	10	10	0.05	0.05	NUM
biomedich-816	10	11	and	and	CCONJ
biomedich-816	10	12	odds	odd	NOUN
biomedich-816	10	13	ratio	ratio	NOUN
biomedich-816	10	14	(	(	PUNCT
biomedich-816	10	15	or	or	CCONJ
biomedich-816	10	16	)	)	PUNCT
biomedich-816	10	17	>	>	X
biomedich-816	11	1	1	1	X
biomedich-816	11	2	.	.	X
biomedich-816	11	3	missense	missense	NOUN
biomedich-816	11	4	mutations	mutation	NOUN
biomedich-816	11	5	in	in	ADP
biomedich-816	11	6	selected	selected	ADJ
biomedich-816	11	7	snps	snps	PROPN
biomedich-816	11	8	were	be	AUX
biomedich-816	11	9	further	far	ADV
biomedich-816	11	10	analyzed	analyze	VERB
biomedich-816	11	11	for	for	ADP
biomedich-816	11	12	gene	gene	NOUN
biomedich-816	11	13	expression	expression	NOUN
biomedich-816	11	14	in	in	ADP
biomedich-816	11	15	lung	lung	NOUN
biomedich-816	11	16	tissue	tissue	NOUN
biomedich-816	11	17	and	and	CCONJ
biomedich-816	11	18	distribution	distribution	NOUN
biomedich-816	11	19	across	across	ADP
biomedich-816	11	20	populations	population	NOUN
biomedich-816	11	21	.	.	PUNCT
biomedich-816	12	1	from	from	ADP
biomedich-816	12	2	an	an	DET
biomedich-816	12	3	initial	initial	ADJ
biomedich-816	12	4	151	151	NUM
biomedich-816	12	5	snps	snps	NOUN
biomedich-816	12	6	,	,	PUNCT
biomedich-816	12	7	86	86	NUM
biomedich-816	12	8	met	meet	VERB
biomedich-816	12	9	the	the	DET
biomedich-816	12	10	statistical	statistical	ADJ
biomedich-816	12	11	criteria	criterion	NOUN
biomedich-816	12	12	,	,	PUNCT
biomedich-816	12	13	and	and	CCONJ
biomedich-816	12	14	six	six	NUM
biomedich-816	12	15	were	be	AUX
biomedich-816	12	16	identified	identify	VERB
biomedich-816	12	17	as	as	ADP
biomedich-816	12	18	missense	missense	NOUN
biomedich-816	12	19	variants	variant	NOUN
biomedich-816	12	20	.	.	PUNCT
biomedich-816	13	1	two	two	NUM
biomedich-816	13	2	genes	gene	NOUN
biomedich-816	13	3	,	,	PUNCT
biomedich-816	13	4	tnip1	tnip1	NOUN
biomedich-816	13	5	and	and	CCONJ
biomedich-816	13	6	psmb8	psmb8	PROPN
biomedich-816	13	7	,	,	PUNCT
biomedich-816	13	8	showed	show	VERB
biomedich-816	13	9	significantly	significantly	ADV
biomedich-816	13	10	high	high	ADJ
biomedich-816	13	11	expression	expression	NOUN
biomedich-816	13	12	in	in	ADP
biomedich-816	13	13	lung	lung	NOUN
biomedich-816	13	14	tissue	tissue	NOUN
biomedich-816	13	15	.	.	PUNCT
biomedich-816	14	1	snp	snp	PROPN
biomedich-816	14	2	rs2071543	rs2071543	PROPN
biomedich-816	14	3	in	in	ADP
biomedich-816	14	4	psmb8	psmb8	PROPN
biomedich-816	14	5	exhibited	exhibit	VERB
biomedich-816	14	6	a	a	DET
biomedich-816	14	7	strong	strong	ADJ
biomedich-816	14	8	correlation	correlation	NOUN
biomedich-816	14	9	with	with	ADP
biomedich-816	14	10	increased	increase	VERB
biomedich-816	14	11	gene	gene	NOUN
biomedich-816	14	12	expression	expression	NOUN
biomedich-816	14	13	and	and	CCONJ
biomedich-816	14	14	demonstrated	demonstrate	VERB
biomedich-816	14	15	notable	notable	ADJ
biomedich-816	14	16	allele	allele	NOUN
biomedich-816	14	17	frequency	frequency	NOUN
biomedich-816	14	18	variation	variation	NOUN
biomedich-816	14	19	across	across	ADP
biomedich-816	14	20	populations	population	NOUN
biomedich-816	14	21	.	.	PUNCT
biomedich-816	15	1	these	these	DET
biomedich-816	15	2	findings	finding	NOUN
biomedich-816	15	3	suggest	suggest	VERB
biomedich-816	15	4	that	that	SCONJ
biomedich-816	15	5	genetic	genetic	ADJ
biomedich-816	15	6	variations	variation	NOUN
biomedich-816	15	7	,	,	PUNCT
biomedich-816	15	8	particularly	particularly	ADV
biomedich-816	15	9	in	in	ADP
biomedich-816	15	10	psmb8	psmb8	NOUN
biomedich-816	15	11	,	,	PUNCT
biomedich-816	15	12	may	may	AUX
biomedich-816	15	13	contribute	contribute	VERB
biomedich-816	15	14	to	to	ADP
biomedich-816	15	15	individual	individual	ADJ
biomedich-816	15	16	susceptibility	susceptibility	NOUN
biomedich-816	15	17	to	to	ADP
biomedich-816	15	18	lung	lung	NOUN
biomedich-816	15	19	diseases	disease	NOUN
biomedich-816	15	20	induced	induce	VERB
biomedich-816	15	21	by	by	ADP
biomedich-816	15	22	environmental	environmental	ADJ
biomedich-816	15	23	exposures	exposure	NOUN
biomedich-816	15	24	.	.	PUNCT
biomedich-816	16	1	this	this	DET
biomedich-816	16	2	study	study	NOUN
biomedich-816	16	3	highlights	highlight	VERB
biomedich-816	16	4	the	the	DET
biomedich-816	16	5	importance	importance	NOUN
biomedich-816	16	6	of	of	ADP
biomedich-816	16	7	multidatabase	multidatabase	ADJ
biomedich-816	16	8	analysis	analysis	NOUN
biomedich-816	16	9	in	in	ADP
biomedich-816	16	10	identifying	identify	VERB
biomedich-816	16	11	genetic	genetic	ADJ
biomedich-816	16	12	biomarkers	biomarker	NOUN
biomedich-816	16	13	and	and	CCONJ
biomedich-816	16	14	provides	provide	VERB
biomedich-816	16	15	a	a	DET
biomedich-816	16	16	foundation	foundation	NOUN
biomedich-816	16	17	for	for	ADP
biomedich-816	16	18	the	the	DET
biomedich-816	16	19	development	development	NOUN
biomedich-816	16	20	of	of	ADP
biomedich-816	16	21	precision	precision	NOUN
biomedich-816	16	22	therapies	therapy	NOUN
biomedich-816	16	23	for	for	ADP
biomedich-816	16	24	multifactorial	multifactorial	ADJ
biomedich-816	16	25	lung	lung	NOUN
biomedich-816	16	26	diseases	disease	NOUN
biomedich-816	16	27	.	.	PUNCT
biomedich-816	17	1	keywords	keyword	NOUN
biomedich-816	17	2	:	:	PUNCT
biomedich-816	17	3	bioinformatics	bioinformatics	NOUN
biomedich-816	17	4	study	study	NOUN
biomedich-816	17	5	;	;	PUNCT
biomedich-816	17	6	environmental	environmental	ADJ
biomedich-816	17	7	exposures	exposure	NOUN
biomedich-816	17	8	;	;	PUNCT
biomedich-816	17	9	lung	lung	NOUN
biomedich-816	17	10	disease	disease	NOUN
biomedich-816	17	11	;	;	PUNCT
biomedich-816	17	12	psmb8	psmb8	NOUN
biomedich-816	17	13	;	;	PUNCT
biomedich-816	17	14	rs2071543	rs2071543	PROPN
biomedich-816	17	15	.	.	PUNCT
biomedich-816	18	1	introduction	introduction	NOUN
biomedich-816	18	2	lung	lung	NOUN
biomedich-816	18	3	diseases	disease	NOUN
biomedich-816	18	4	remain	remain	VERB
biomedich-816	18	5	one	one	NUM
biomedich-816	18	6	of	of	ADP
biomedich-816	18	7	the	the	DET
biomedich-816	18	8	leading	lead	VERB
biomedich-816	18	9	causes	cause	NOUN
biomedich-816	18	10	of	of	ADP
biomedich-816	18	11	morbidity	morbidity	NOUN
biomedich-816	18	12	and	and	CCONJ
biomedich-816	18	13	mortality	mortality	NOUN
biomedich-816	18	14	worldwide	worldwide	ADV
biomedich-816	18	15	.	.	PUNCT
biomedich-816	19	1	conditions	condition	NOUN
biomedich-816	19	2	such	such	ADJ
biomedich-816	19	3	as	as	ADP
biomedich-816	19	4	chronic	chronic	ADJ
biomedich-816	19	5	obstructive	obstructive	ADJ
biomedich-816	19	6	pulmonary	pulmonary	ADJ
biomedich-816	19	7	disease	disease	NOUN
biomedich-816	19	8	(	(	PUNCT
biomedich-816	19	9	copd	copd	PROPN
biomedich-816	19	10	)	)	PUNCT
biomedich-816	19	11	,	,	PUNCT
biomedich-816	19	12	idiopathic	idiopathic	ADJ
biomedich-816	19	13	pulmonary	pulmonary	ADJ
biomedich-816	19	14	fibrosis	fibrosis	NOUN
biomedich-816	19	15	(	(	PUNCT
biomedich-816	19	16	ipf	ipf	NOUN
biomedich-816	19	17	)	)	PUNCT
biomedich-816	19	18	,	,	PUNCT
biomedich-816	19	19	asthma	asthma	NOUN
biomedich-816	19	20	,	,	PUNCT
biomedich-816	19	21	and	and	CCONJ
biomedich-816	19	22	lung	lung	NOUN
biomedich-816	19	23	cancer	cancer	NOUN
biomedich-816	19	24	are	be	AUX
biomedich-816	19	25	showing	show	VERB
biomedich-816	19	26	increasing	increase	VERB
biomedich-816	19	27	prevalence	prevalence	NOUN
biomedich-816	19	28	,	,	PUNCT
biomedich-816	19	29	particularly	particularly	ADV
biomedich-816	19	30	among	among	ADP
biomedich-816	19	31	populations	population	NOUN
biomedich-816	19	32	exposed	expose	VERB
biomedich-816	19	33	to	to	ADP
biomedich-816	19	34	harmful	harmful	ADJ
biomedich-816	19	35	environmental	environmental	ADJ
biomedich-816	19	36	factors	factor	NOUN
biomedich-816	19	37	(	(	PUNCT
biomedich-816	19	38	victoni	victoni	INTJ
biomedich-816	19	39	et	et	PROPN
biomedich-816	19	40	al	al	PROPN
biomedich-816	19	41	.	.	PROPN
biomedich-816	19	42	,	,	PUNCT
biomedich-816	19	43	2021	2021	NUM
biomedich-816	19	44	)	)	PUNCT
biomedich-816	19	45	.	.	PUNCT
biomedich-816	20	1	the	the	DET
biomedich-816	20	2	complex	complex	ADJ
biomedich-816	20	3	pathogenesis	pathogenesis	NOUN
biomedich-816	20	4	of	of	ADP
biomedich-816	20	5	these	these	DET
biomedich-816	20	6	diseases	disease	NOUN
biomedich-816	20	7	reflects	reflect	VERB
biomedich-816	20	8	the	the	DET
biomedich-816	20	9	involvement	involvement	NOUN
biomedich-816	20	10	of	of	ADP
biomedich-816	20	11	multiple	multiple	ADJ
biomedich-816	20	12	biological	biological	ADJ
biomedich-816	20	13	mechanisms	mechanism	NOUN
biomedich-816	20	14	,	,	PUNCT
biomedich-816	20	15	including	include	VERB
biomedich-816	20	16	oxidative	oxidative	ADJ
biomedich-816	20	17	stress	stress	NOUN
biomedich-816	20	18	,	,	PUNCT
biomedich-816	20	19	chronic	chronic	ADJ
biomedich-816	20	20	inflammation	inflammation	NOUN
biomedich-816	20	21	,	,	PUNCT
biomedich-816	20	22	and	and	CCONJ
biomedich-816	20	23	innate	innate	ADJ
biomedich-816	20	24	genetic	genetic	ADJ
biomedich-816	20	25	factors	factor	NOUN
biomedich-816	20	26	that	that	PRON
biomedich-816	20	27	may	may	AUX
biomedich-816	20	28	influence	influence	VERB
biomedich-816	20	29	an	an	DET
biomedich-816	20	30	individual	individual	NOUN
biomedich-816	20	31	’s	’s	PART
biomedich-816	20	32	response	response	NOUN
biomedich-816	20	33	to	to	ADP
biomedich-816	20	34	external	external	ADJ
biomedich-816	20	35	exposures	exposure	NOUN
biomedich-816	20	36	(	(	PUNCT
biomedich-816	20	37	victoni	victoni	INTJ
biomedich-816	20	38	et	et	PROPN
biomedich-816	20	39	al	al	PROPN
biomedich-816	20	40	.	.	PROPN
biomedich-816	20	41	,	,	PUNCT
biomedich-816	20	42	2021	2021	NUM
biomedich-816	20	43	)	)	PUNCT
biomedich-816	20	44	.	.	PUNCT
biomedich-816	21	1	one	one	NUM
biomedich-816	21	2	of	of	ADP
biomedich-816	21	3	the	the	DET
biomedich-816	21	4	key	key	ADJ
biomedich-816	21	5	mechanisms	mechanism	NOUN
biomedich-816	21	6	contributing	contribute	VERB
biomedich-816	21	7	to	to	ADP
biomedich-816	21	8	lung	lung	NOUN
biomedich-816	21	9	tissue	tissue	NOUN
biomedich-816	21	10	damage	damage	NOUN
biomedich-816	21	11	is	be	AUX
biomedich-816	21	12	oxidative	oxidative	ADJ
biomedich-816	21	13	stress	stress	NOUN
biomedich-816	21	14	,	,	PUNCT
biomedich-816	21	15	which	which	PRON
biomedich-816	21	16	results	result	VERB
biomedich-816	21	17	from	from	ADP
biomedich-816	21	18	an	an	DET
biomedich-816	21	19	imbalance	imbalance	NOUN
biomedich-816	21	20	between	between	ADP
biomedich-816	21	21	the	the	DET
biomedich-816	21	22	production	production	NOUN
biomedich-816	21	23	of	of	ADP
biomedich-816	21	24	reactive	reactive	ADJ
biomedich-816	21	25	oxygen	oxygen	NOUN
biomedich-816	21	26	species	specie	NOUN
biomedich-816	21	27	(	(	PUNCT
biomedich-816	21	28	ros	ros	PROPN
biomedich-816	21	29	)	)	PUNCT
biomedich-816	21	30	and	and	CCONJ
biomedich-816	21	31	the	the	DET
biomedich-816	21	32	body	body	NOUN
biomedich-816	21	33	’s	’s	PART
biomedich-816	21	34	antioxidant	antioxidant	ADJ
biomedich-816	21	35	defense	defense	NOUN
biomedich-816	21	36	systems	system	NOUN
biomedich-816	21	37	.	.	PUNCT
biomedich-816	22	1	ros	ros	PROPN
biomedich-816	22	2	can	can	AUX
biomedich-816	22	3	trigger	trigger	VERB
biomedich-816	22	4	inflammation	inflammation	NOUN
biomedich-816	22	5	,	,	PUNCT
biomedich-816	22	6	apoptosis	apoptosis	NOUN
biomedich-816	22	7	,	,	PUNCT
biomedich-816	22	8	and	and	CCONJ
biomedich-816	22	9	tissue	tissue	NOUN
biomedich-816	22	10	remodeling	remodeling	NOUN
biomedich-816	22	11	,	,	PUNCT
biomedich-816	22	12	ultimately	ultimately	ADV
biomedich-816	22	13	leading	lead	VERB
biomedich-816	22	14	to	to	ADP
biomedich-816	22	15	organ	organ	VERB
biomedich-816	22	16	dysfunction	dysfunction	NOUN
biomedich-816	22	17	over	over	ADP
biomedich-816	22	18	time	time	NOUN
biomedich-816	22	19	(	(	PUNCT
biomedich-816	22	20	victoni	victoni	INTJ
biomedich-816	22	21	et	et	PROPN
biomedich-816	22	22	al	al	PROPN
biomedich-816	22	23	.	.	PROPN
biomedich-816	22	24	,	,	PUNCT
biomedich-816	22	25	2021	2021	NUM
biomedich-816	22	26	)	)	PUNCT
biomedich-816	22	27	.	.	PUNCT
biomedich-816	23	1	this	this	DET
biomedich-816	23	2	condition	condition	NOUN
biomedich-816	23	3	is	be	AUX
biomedich-816	23	4	further	far	ADV
biomedich-816	23	5	exacerbated	exacerbate	VERB
biomedich-816	23	6	by	by	ADP
biomedich-816	23	7	the	the	DET
biomedich-816	23	8	limited	limited	ADJ
biomedich-816	23	9	effectiveness	effectiveness	NOUN
biomedich-816	23	10	of	of	ADP
biomedich-816	23	11	conventional	conventional	ADJ
biomedich-816	23	12	therapies	therapy	NOUN
biomedich-816	23	13	for	for	ADP
biomedich-816	23	14	certain	certain	ADJ
biomedich-816	23	15	chronic	chronic	ADJ
biomedich-816	23	16	lung	lung	NOUN
biomedich-816	23	17	diseases	disease	NOUN
biomedich-816	23	18	,	,	PUNCT
biomedich-816	23	19	such	such	ADJ
biomedich-816	23	20	as	as	ADP
biomedich-816	23	21	copd	copd	NOUN
biomedich-816	23	22	and	and	CCONJ
biomedich-816	23	23	ipf	ipf	VERB
biomedich-816	23	24	,	,	PUNCT
biomedich-816	23	25	highlighting	highlight	VERB
biomedich-816	23	26	the	the	DET
biomedich-816	23	27	need	need	NOUN
biomedich-816	23	28	for	for	ADP
biomedich-816	23	29	more	more	ADV
biomedich-816	23	30	targeted	targeted	ADJ
biomedich-816	23	31	and	and	CCONJ
biomedich-816	23	32	specific	specific	ADJ
biomedich-816	23	33	therapeutic	therapeutic	ADJ
biomedich-816	23	34	approaches	approach	NOUN
biomedich-816	23	35	(	(	PUNCT
biomedich-816	23	36	harber	harber	PROPN
biomedich-816	23	37	et	et	PROPN
biomedich-816	23	38	al	al	PROPN
biomedich-816	23	39	.	.	PROPN
biomedich-816	23	40	,	,	PUNCT
biomedich-816	23	41	2016	2016	NUM
biomedich-816	23	42	)	)	PUNCT
biomedich-816	23	43	.	.	PUNCT
biomedich-816	24	1	environmental	environmental	ADJ
biomedich-816	24	2	and	and	CCONJ
biomedich-816	24	3	occupational	occupational	ADJ
biomedich-816	24	4	factors	factor	NOUN
biomedich-816	24	5	have	have	AUX
biomedich-816	24	6	been	be	AUX
biomedich-816	24	7	identified	identify	VERB
biomedich-816	24	8	as	as	ADP
biomedich-816	24	9	major	major	ADJ
biomedich-816	24	10	contributors	contributor	NOUN
biomedich-816	24	11	to	to	ADP
biomedich-816	24	12	the	the	DET
biomedich-816	24	13	etiology	etiology	NOUN
biomedich-816	24	14	of	of	ADP
biomedich-816	24	15	lung	lung	NOUN
biomedich-816	24	16	diseases	disease	NOUN
biomedich-816	24	17	.	.	PUNCT
biomedich-816	25	1	individuals	individual	NOUN
biomedich-816	25	2	working	work	VERB
biomedich-816	25	3	in	in	ADP
biomedich-816	25	4	agriculture	agriculture	NOUN
biomedich-816	25	5	and	and	CCONJ
biomedich-816	25	6	livestock	livestock	NOUN
biomedich-816	25	7	industries	industry	NOUN
biomedich-816	25	8	,	,	PUNCT
biomedich-816	25	9	for	for	ADP
biomedich-816	25	10	example	example	NOUN
biomedich-816	25	11	,	,	PUNCT
biomedich-816	25	12	are	be	AUX
biomedich-816	25	13	at	at	ADP
biomedich-816	25	14	high	high	ADJ
biomedich-816	25	15	risk	risk	NOUN
biomedich-816	25	16	of	of	ADP
biomedich-816	25	17	exposure	exposure	NOUN
biomedich-816	25	18	to	to	ADP
biomedich-816	25	19	organic	organic	ADJ
biomedich-816	25	20	dust	dust	NOUN
biomedich-816	25	21	,	,	PUNCT
biomedich-816	25	22	which	which	PRON
biomedich-816	25	23	is	be	AUX
biomedich-816	25	24	known	know	VERB
biomedich-816	25	25	to	to	PART
biomedich-816	25	26	trigger	trigger	VERB
biomedich-816	25	27	occupational	occupational	ADJ
biomedich-816	25	28	asthma	asthma	NOUN
biomedich-816	25	29	,	,	PUNCT
biomedich-816	25	30	chronic	chronic	ADJ
biomedich-816	25	31	bronchitis	bronchitis	NOUN
biomedich-816	25	32	,	,	PUNCT
biomedich-816	25	33	and	and	CCONJ
biomedich-816	25	34	even	even	ADV
biomedich-816	25	35	pulmonary	pulmonary	ADJ
biomedich-816	25	36	fibrosis	fibrosis	NOUN
biomedich-816	25	37	(	(	PUNCT
biomedich-816	25	38	poole	poole	NOUN
biomedich-816	25	39	et	et	PROPN
biomedich-816	25	40	al	al	PROPN
biomedich-816	25	41	.	.	PROPN
biomedich-816	25	42	,	,	PUNCT
biomedich-816	25	43	2024	2024	NUM
biomedich-816	25	44	)	)	PUNCT
biomedich-816	25	45	.	.	PUNCT
biomedich-816	26	1	additionally	additionally	ADV
biomedich-816	26	2	,	,	PUNCT
biomedich-816	26	3	air	air	NOUN
biomedich-816	26	4	pollution	pollution	NOUN
biomedich-816	26	5	from	from	ADP
biomedich-816	26	6	motor	motor	NOUN
biomedich-816	26	7	vehicle	vehicle	NOUN
biomedich-816	26	8	emissions	emission	NOUN
biomedich-816	26	9	and	and	CCONJ
biomedich-816	26	10	industrial	industrial	ADJ
biomedich-816	26	11	activities	activity	NOUN
biomedich-816	26	12	has	have	AUX
biomedich-816	26	13	been	be	AUX
biomedich-816	26	14	shown	show	VERB
biomedich-816	26	15	to	to	PART
biomedich-816	26	16	significantly	significantly	ADV
biomedich-816	26	17	impair	impair	VERB
biomedich-816	26	18	lung	lung	NOUN
biomedich-816	26	19	function	function	NOUN
biomedich-816	26	20	,	,	PUNCT
biomedich-816	26	21	as	as	SCONJ
biomedich-816	26	22	evidenced	evidence	VERB
biomedich-816	26	23	by	by	ADP
biomedich-816	26	24	numerous	numerous	ADJ
biomedich-816	26	25	epidemiological	epidemiological	ADJ
biomedich-816	26	26	studies	study	NOUN
biomedich-816	26	27	and	and	CCONJ
biomedich-816	26	28	meta	meta	NOUN
biomedich-816	26	29	-	-	PUNCT
biomedich-816	26	30	analyses	analysis	NOUN
biomedich-816	26	31	(	(	PUNCT
biomedich-816	26	32	adam	adam	PROPN
biomedich-816	26	33	et	et	PROPN
biomedich-816	26	34	al	al	PROPN
biomedich-816	26	35	.	.	PROPN
biomedich-816	26	36	,	,	PUNCT
biomedich-816	26	37	2015	2015	NUM
biomedich-816	26	38	)	)	PUNCT
biomedich-816	26	39	.	.	PUNCT
biomedich-816	27	1	synthetic	synthetic	ADJ
biomedich-816	27	2	food	food	NOUN
biomedich-816	27	3	additives	additive	NOUN
biomedich-816	27	4	such	such	ADJ
biomedich-816	27	5	as	as	ADP
biomedich-816	27	6	sodium	sodium	NOUN
biomedich-816	27	7	nitrite	nitrite	NOUN
biomedich-816	27	8	,	,	PUNCT
biomedich-816	27	9	artificial	artificial	ADJ
biomedich-816	27	10	coloring	coloring	NOUN
biomedich-816	27	11	agents	agent	NOUN
biomedich-816	27	12	,	,	PUNCT
biomedich-816	27	13	and	and	CCONJ
biomedich-816	27	14	sulfites	sulfite	NOUN
biomedich-816	27	15	also	also	ADV
biomedich-816	27	16	contribute	contribute	VERB
biomedich-816	27	17	to	to	ADP
biomedich-816	27	18	impaired	impaired	ADJ
biomedich-816	27	19	lung	lung	NOUN
biomedich-816	27	20	function	function	NOUN
biomedich-816	27	21	,	,	PUNCT
biomedich-816	27	22	particularly	particularly	ADV
biomedich-816	27	23	in	in	ADP
biomedich-816	27	24	individuals	individual	NOUN
biomedich-816	27	25	with	with	ADP
biomedich-816	27	26	airway	airway	NOUN
biomedich-816	27	27	hyperresponsiveness	hyperresponsiveness	NOUN
biomedich-816	27	28	(	(	PUNCT
biomedich-816	27	29	aldabayan	aldabayan	ADJ
biomedich-816	27	30	,	,	PUNCT
biomedich-816	27	31	2025	2025	NUM
biomedich-816	27	32	)	)	PUNCT
biomedich-816	27	33	.	.	PUNCT
biomedich-816	28	1	these	these	DET
biomedich-816	28	2	exposures	exposure	NOUN
biomedich-816	28	3	can	can	AUX
biomedich-816	28	4	elicit	elicit	VERB
biomedich-816	28	5	abnormal	abnormal	ADJ
biomedich-816	28	6	immune	immune	ADJ
biomedich-816	28	7	responses	response	NOUN
biomedich-816	28	8	,	,	PUNCT
biomedich-816	28	9	compromise	compromise	VERB
biomedich-816	28	10	epithelial	epithelial	ADJ
biomedich-816	28	11	integrity	integrity	NOUN
biomedich-816	28	12	,	,	PUNCT
biomedich-816	28	13	and	and	CCONJ
biomedich-816	28	14	accelerate	accelerate	VERB
biomedich-816	28	15	disease	disease	NOUN
biomedich-816	28	16	progression	progression	NOUN
biomedich-816	28	17	,	,	PUNCT
biomedich-816	28	18	especially	especially	ADV
biomedich-816	28	19	in	in	ADP
biomedich-816	28	20	genetically	genetically	ADV
biomedich-816	28	21	susceptible	susceptible	ADJ
biomedich-816	28	22	individuals	individual	NOUN
biomedich-816	28	23	.	.	PUNCT
biomedich-816	29	1	at	at	ADP
biomedich-816	29	2	the	the	DET
biomedich-816	29	3	cellular	cellular	ADJ
biomedich-816	29	4	and	and	CCONJ
biomedich-816	29	5	molecular	molecular	ADJ
biomedich-816	29	6	levels	level	NOUN
biomedich-816	29	7	,	,	PUNCT
biomedich-816	29	8	chronic	chronic	ADJ
biomedich-816	29	9	lung	lung	NOUN
biomedich-816	29	10	diseases	disease	NOUN
biomedich-816	29	11	such	such	ADJ
biomedich-816	29	12	as	as	ADP
biomedich-816	29	13	ipf	ipf	PRON
biomedich-816	29	14	have	have	AUX
biomedich-816	29	15	been	be	AUX
biomedich-816	29	16	associated	associate	VERB
biomedich-816	29	17	with	with	ADP
biomedich-816	29	18	a	a	DET
biomedich-816	29	19	programmed	program	VERB
biomedich-816	29	20	cell	cell	NOUN
biomedich-816	29	21	death	death	NOUN
biomedich-816	29	22	mechanism	mechanism	NOUN
biomedich-816	29	23	known	know	VERB
biomedich-816	29	24	as	as	ADP
biomedich-816	29	25	ferroptosis	ferroptosis	NOUN
biomedich-816	29	26	https://doi.org/10.14421/biomedich.2025.142.717-723	https://doi.org/10.14421/biomedich.2025.142.717-723	PROPN
biomedich-816	29	27	718	718	NUM
biomedich-816	29	28	biology	biology	NOUN
biomedich-816	29	29	,	,	PUNCT
biomedich-816	29	30	medicine	medicine	NOUN
biomedich-816	29	31	,	,	PUNCT
biomedich-816	29	32	&	&	CCONJ
biomedich-816	29	33	natural	natural	ADJ
biomedich-816	29	34	product	product	NOUN
biomedich-816	29	35	chemistry	chemistry	NOUN
biomedich-816	29	36	14	14	NUM
biomedich-816	29	37	(	(	PUNCT
biomedich-816	29	38	2	2	NUM
biomedich-816	29	39	)	)	PUNCT
biomedich-816	29	40	,	,	PUNCT
biomedich-816	29	41	2025	2025	NUM
biomedich-816	29	42	:	:	PUNCT
biomedich-816	30	1	717	717	NUM
biomedich-816	30	2	-	-	SYM
biomedich-816	30	3	723	723	NUM
biomedich-816	30	4	a	a	DET
biomedich-816	30	5	process	process	NOUN
biomedich-816	30	6	triggered	trigger	VERB
biomedich-816	30	7	by	by	ADP
biomedich-816	30	8	iron	iron	NOUN
biomedich-816	30	9	accumulation	accumulation	NOUN
biomedich-816	30	10	and	and	CCONJ
biomedich-816	30	11	oxidative	oxidative	ADJ
biomedich-816	30	12	stress	stress	NOUN
biomedich-816	30	13	.	.	PUNCT
biomedich-816	31	1	unlike	unlike	ADP
biomedich-816	31	2	apoptosis	apoptosis	NOUN
biomedich-816	31	3	or	or	CCONJ
biomedich-816	31	4	necrosis	necrosis	NOUN
biomedich-816	31	5	,	,	PUNCT
biomedich-816	31	6	ferroptosis	ferroptosis	NOUN
biomedich-816	31	7	represents	represent	VERB
biomedich-816	31	8	a	a	DET
biomedich-816	31	9	distinct	distinct	ADJ
biomedich-816	31	10	cell	cell	NOUN
biomedich-816	31	11	death	death	NOUN
biomedich-816	31	12	pathway	pathway	NOUN
biomedich-816	31	13	and	and	CCONJ
biomedich-816	31	14	has	have	AUX
biomedich-816	31	15	emerged	emerge	VERB
biomedich-816	31	16	as	as	ADP
biomedich-816	31	17	a	a	DET
biomedich-816	31	18	potential	potential	ADJ
biomedich-816	31	19	target	target	NOUN
biomedich-816	31	20	in	in	ADP
biomedich-816	31	21	novel	novel	ADJ
biomedich-816	31	22	therapeutic	therapeutic	ADJ
biomedich-816	31	23	research	research	NOUN
biomedich-816	31	24	(	(	PUNCT
biomedich-816	31	25	he	he	PRON
biomedich-816	31	26	et	et	PROPN
biomedich-816	31	27	al	al	PROPN
biomedich-816	31	28	.	.	PROPN
biomedich-816	31	29	,	,	PUNCT
biomedich-816	31	30	2022	2022	NUM
biomedich-816	31	31	)	)	PUNCT
biomedich-816	31	32	.	.	PUNCT
biomedich-816	32	1	several	several	ADJ
biomedich-816	32	2	genes	gene	NOUN
biomedich-816	32	3	,	,	PUNCT
biomedich-816	32	4	including	include	VERB
biomedich-816	32	5	cav1	cav1	NOUN
biomedich-816	32	6	,	,	PUNCT
biomedich-816	32	7	gdf15	gdf15	NOUN
biomedich-816	32	8	,	,	PUNCT
biomedich-816	32	9	nos2	nos2	NOUN
biomedich-816	32	10	,	,	PUNCT
biomedich-816	32	11	and	and	CCONJ
biomedich-816	32	12	cdkn2a	cdkn2a	PROPN
biomedich-816	32	13	,	,	PUNCT
biomedich-816	32	14	have	have	AUX
biomedich-816	32	15	been	be	AUX
biomedich-816	32	16	found	find	VERB
biomedich-816	32	17	to	to	PART
biomedich-816	32	18	be	be	AUX
biomedich-816	32	19	dysregulated	dysregulate	VERB
biomedich-816	32	20	in	in	ADP
biomedich-816	32	21	the	the	DET
biomedich-816	32	22	lung	lung	NOUN
biomedich-816	32	23	tissues	tissue	NOUN
biomedich-816	32	24	of	of	ADP
biomedich-816	32	25	ipf	ipf	VERB
biomedich-816	32	26	patients	patient	NOUN
biomedich-816	32	27	and	and	CCONJ
biomedich-816	32	28	are	be	AUX
biomedich-816	32	29	all	all	PRON
biomedich-816	32	30	involved	involved	ADJ
biomedich-816	32	31	in	in	ADP
biomedich-816	32	32	ferroptosis	ferroptosis	NOUN
biomedich-816	32	33	-	-	PUNCT
biomedich-816	32	34	related	relate	VERB
biomedich-816	32	35	regulatory	regulatory	ADJ
biomedich-816	32	36	pathways	pathway	NOUN
biomedich-816	32	37	(	(	PUNCT
biomedich-816	32	38	he	he	PRON
biomedich-816	32	39	et	et	PROPN
biomedich-816	32	40	al	al	PROPN
biomedich-816	32	41	.	.	PROPN
biomedich-816	32	42	,	,	PUNCT
biomedich-816	32	43	2022	2022	NUM
biomedich-816	32	44	)	)	PUNCT
biomedich-816	32	45	.	.	PUNCT
biomedich-816	33	1	these	these	DET
biomedich-816	33	2	findings	finding	NOUN
biomedich-816	33	3	suggest	suggest	VERB
biomedich-816	33	4	that	that	SCONJ
biomedich-816	33	5	therapeutic	therapeutic	ADJ
biomedich-816	33	6	strategies	strategy	NOUN
biomedich-816	33	7	aimed	aim	VERB
biomedich-816	33	8	at	at	ADP
biomedich-816	33	9	inhibiting	inhibit	VERB
biomedich-816	33	10	or	or	CCONJ
biomedich-816	33	11	modulating	modulate	VERB
biomedich-816	33	12	ferroptosis	ferroptosis	NOUN
biomedich-816	33	13	pathways	pathway	NOUN
biomedich-816	33	14	may	may	AUX
biomedich-816	33	15	offer	offer	VERB
biomedich-816	33	16	innovative	innovative	ADJ
biomedich-816	33	17	approaches	approach	NOUN
biomedich-816	33	18	for	for	ADP
biomedich-816	33	19	managing	manage	VERB
biomedich-816	33	20	ipf	ipf	NOUN
biomedich-816	33	21	and	and	CCONJ
biomedich-816	33	22	other	other	ADJ
biomedich-816	33	23	lung	lung	NOUN
biomedich-816	33	24	diseases	disease	NOUN
biomedich-816	33	25	.	.	PUNCT
biomedich-816	34	1	furthermore	furthermore	ADV
biomedich-816	34	2	,	,	PUNCT
biomedich-816	34	3	chronic	chronic	ADJ
biomedich-816	34	4	exposure	exposure	NOUN
biomedich-816	34	5	to	to	ADP
biomedich-816	34	6	cigarette	cigarette	NOUN
biomedich-816	34	7	smoke	smoke	NOUN
biomedich-816	34	8	plays	play	VERB
biomedich-816	34	9	a	a	DET
biomedich-816	34	10	significant	significant	ADJ
biomedich-816	34	11	role	role	NOUN
biomedich-816	34	12	in	in	ADP
biomedich-816	34	13	inducing	induce	VERB
biomedich-816	34	14	systemic	systemic	ADJ
biomedich-816	34	15	genetic	genetic	ADJ
biomedich-816	34	16	alterations	alteration	NOUN
biomedich-816	34	17	.	.	PUNCT
biomedich-816	35	1	a	a	DET
biomedich-816	35	2	wellcharacterized	wellcharacterize	VERB
biomedich-816	35	3	molecular	molecular	ADJ
biomedich-816	35	4	marker	marker	NOUN
biomedich-816	35	5	of	of	ADP
biomedich-816	35	6	smoke	smoke	NOUN
biomedich-816	35	7	exposure	exposure	NOUN
biomedich-816	35	8	is	be	AUX
biomedich-816	35	9	the	the	DET
biomedich-816	35	10	sbs4	sbs4	PROPN
biomedich-816	35	11	mutational	mutational	ADJ
biomedich-816	35	12	signature	signature	NOUN
biomedich-816	35	13	,	,	PUNCT
biomedich-816	35	14	which	which	PRON
biomedich-816	35	15	is	be	AUX
biomedich-816	35	16	closely	closely	ADV
biomedich-816	35	17	associated	associate	VERB
biomedich-816	35	18	with	with	ADP
biomedich-816	35	19	carcinogenesis	carcinogenesis	NOUN
biomedich-816	35	20	and	and	CCONJ
biomedich-816	35	21	lung	lung	NOUN
biomedich-816	35	22	tissue	tissue	NOUN
biomedich-816	35	23	remodeling	remodeling	NOUN
biomedich-816	35	24	(	(	PUNCT
biomedich-816	35	25	kim	kim	PROPN
biomedich-816	35	26	et	et	PROPN
biomedich-816	35	27	al	al	PROPN
biomedich-816	35	28	.	.	PROPN
biomedich-816	35	29	,	,	PUNCT
biomedich-816	35	30	2022	2022	NUM
biomedich-816	35	31	)	)	PUNCT
biomedich-816	35	32	.	.	PUNCT
biomedich-816	36	1	remarkably	remarkably	ADV
biomedich-816	36	2	,	,	PUNCT
biomedich-816	36	3	this	this	DET
biomedich-816	36	4	signature	signature	NOUN
biomedich-816	36	5	can	can	AUX
biomedich-816	36	6	be	be	AUX
biomedich-816	36	7	detected	detect	VERB
biomedich-816	36	8	even	even	ADV
biomedich-816	36	9	in	in	ADP
biomedich-816	36	10	non	non	ADJ
biomedich-816	36	11	-	-	ADJ
biomedich-816	36	12	malignant	malignant	ADJ
biomedich-816	36	13	lung	lung	NOUN
biomedich-816	36	14	tissues	tissue	NOUN
biomedich-816	36	15	,	,	PUNCT
biomedich-816	36	16	indicating	indicate	VERB
biomedich-816	36	17	that	that	SCONJ
biomedich-816	36	18	environmental	environmental	ADJ
biomedich-816	36	19	exposure	exposure	NOUN
biomedich-816	36	20	can	can	AUX
biomedich-816	36	21	induce	induce	VERB
biomedich-816	36	22	genetic	genetic	ADJ
biomedich-816	36	23	changes	change	NOUN
biomedich-816	36	24	long	long	ADV
biomedich-816	36	25	before	before	SCONJ
biomedich-816	36	26	clinical	clinical	ADJ
biomedich-816	36	27	symptoms	symptom	NOUN
biomedich-816	36	28	emerge	emerge	VERB
biomedich-816	36	29	(	(	PUNCT
biomedich-816	36	30	kim	kim	PROPN
biomedich-816	36	31	et	et	PROPN
biomedich-816	36	32	al	al	PROPN
biomedich-816	36	33	.	.	PROPN
biomedich-816	36	34	,	,	PUNCT
biomedich-816	36	35	2022	2022	NUM
biomedich-816	36	36	;	;	PUNCT
biomedich-816	36	37	valavanidis	valavanidis	PROPN
biomedich-816	36	38	et	et	PROPN
biomedich-816	36	39	al	al	PROPN
biomedich-816	36	40	.	.	PROPN
biomedich-816	36	41	,	,	PUNCT
biomedich-816	36	42	2009	2009	NUM
biomedich-816	36	43	)	)	PUNCT
biomedich-816	36	44	.	.	PUNCT
biomedich-816	37	1	the	the	DET
biomedich-816	37	2	ros	ros	PROPN
biomedich-816	37	3	present	present	NOUN
biomedich-816	37	4	in	in	ADP
biomedich-816	37	5	cigarette	cigarette	NOUN
biomedich-816	37	6	smoke	smoke	NOUN
biomedich-816	37	7	intensify	intensify	VERB
biomedich-816	37	8	oxidative	oxidative	ADJ
biomedich-816	37	9	stress	stress	NOUN
biomedich-816	37	10	,	,	PUNCT
biomedich-816	37	11	accelerate	accelerate	VERB
biomedich-816	37	12	degenerative	degenerative	ADJ
biomedich-816	37	13	processes	process	NOUN
biomedich-816	37	14	,	,	PUNCT
biomedich-816	37	15	and	and	CCONJ
biomedich-816	37	16	cause	cause	VERB
biomedich-816	37	17	dna	dna	NOUN
biomedich-816	37	18	damage	damage	NOUN
biomedich-816	37	19	(	(	PUNCT
biomedich-816	37	20	valavanidis	valavanidi	NOUN
biomedich-816	37	21	et	et	PROPN
biomedich-816	37	22	al	al	PROPN
biomedich-816	37	23	.	.	PROPN
biomedich-816	37	24	,	,	PUNCT
biomedich-816	37	25	2009	2009	NUM
biomedich-816	37	26	)	)	PUNCT
biomedich-816	37	27	.	.	PUNCT
biomedich-816	38	1	the	the	DET
biomedich-816	38	2	extensive	extensive	ADJ
biomedich-816	38	3	application	application	NOUN
biomedich-816	38	4	of	of	ADP
biomedich-816	38	5	bioinformatics	bioinformatics	NOUN
biomedich-816	38	6	allows	allow	VERB
biomedich-816	38	7	researchers	researcher	NOUN
biomedich-816	38	8	to	to	PART
biomedich-816	38	9	integrate	integrate	VERB
biomedich-816	38	10	diverse	diverse	ADJ
biomedich-816	38	11	omics	omic	NOUN
biomedich-816	38	12	data	datum	NOUN
biomedich-816	38	13	—	—	PUNCT
biomedich-816	38	14	including	include	VERB
biomedich-816	38	15	transcriptomics	transcriptomic	NOUN
biomedich-816	38	16	,	,	PUNCT
biomedich-816	38	17	proteomics	proteomic	NOUN
biomedich-816	38	18	,	,	PUNCT
biomedich-816	38	19	and	and	CCONJ
biomedich-816	38	20	dna	dna	NOUN
biomedich-816	38	21	mutation	mutation	NOUN
biomedich-816	38	22	profiles	profile	NOUN
biomedich-816	38	23	to	to	PART
biomedich-816	38	24	uncover	uncover	VERB
biomedich-816	38	25	previously	previously	ADV
biomedich-816	38	26	hidden	hide	VERB
biomedich-816	38	27	patterns	pattern	NOUN
biomedich-816	38	28	of	of	ADP
biomedich-816	38	29	lung	lung	NOUN
biomedich-816	38	30	pathology	pathology	NOUN
biomedich-816	38	31	(	(	PUNCT
biomedich-816	38	32	he	he	PRON
biomedich-816	38	33	et	et	PROPN
biomedich-816	38	34	al	al	PROPN
biomedich-816	38	35	.	.	PROPN
biomedich-816	38	36	,	,	PUNCT
biomedich-816	38	37	2022	2022	NUM
biomedich-816	38	38	)	)	PUNCT
biomedich-816	38	39	.	.	PUNCT
biomedich-816	39	1	this	this	DET
biomedich-816	39	2	approach	approach	NOUN
biomedich-816	39	3	has	have	AUX
biomedich-816	39	4	also	also	ADV
biomedich-816	39	5	been	be	AUX
biomedich-816	39	6	employed	employ	VERB
biomedich-816	39	7	to	to	PART
biomedich-816	39	8	assess	assess	VERB
biomedich-816	39	9	immune	immune	ADJ
biomedich-816	39	10	responses	response	NOUN
biomedich-816	39	11	to	to	ADP
biomedich-816	39	12	organic	organic	ADJ
biomedich-816	39	13	dust	dust	NOUN
biomedich-816	39	14	exposure	exposure	NOUN
biomedich-816	39	15	and	and	CCONJ
biomedich-816	39	16	to	to	PART
biomedich-816	39	17	identify	identify	AUX
biomedich-816	39	18	disrupted	disrupt	VERB
biomedich-816	39	19	signaling	signal	VERB
biomedich-816	39	20	pathways	pathway	NOUN
biomedich-816	39	21	resulting	result	VERB
biomedich-816	39	22	from	from	ADP
biomedich-816	39	23	food	food	NOUN
biomedich-816	39	24	additive	additive	ADJ
biomedich-816	39	25	exposure	exposure	NOUN
biomedich-816	39	26	(	(	PUNCT
biomedich-816	39	27	aldabayan	aldabayan	ADJ
biomedich-816	39	28	,	,	PUNCT
biomedich-816	39	29	2025	2025	NUM
biomedich-816	39	30	;	;	PUNCT
biomedich-816	39	31	poole	poole	NOUN
biomedich-816	39	32	et	et	PROPN
biomedich-816	39	33	al	al	PROPN
biomedich-816	39	34	.	.	PROPN
biomedich-816	39	35	,	,	PUNCT
biomedich-816	39	36	2024	2024	NUM
biomedich-816	39	37	)	)	PUNCT
biomedich-816	39	38	.	.	PUNCT
biomedich-816	40	1	in	in	ADP
biomedich-816	40	2	the	the	DET
biomedich-816	40	3	era	era	NOUN
biomedich-816	40	4	of	of	ADP
biomedich-816	40	5	precision	precision	NOUN
biomedich-816	40	6	medicine	medicine	NOUN
biomedich-816	40	7	,	,	PUNCT
biomedich-816	40	8	such	such	ADJ
biomedich-816	40	9	molecular	molecular	ADJ
biomedich-816	40	10	understanding	understanding	NOUN
biomedich-816	40	11	is	be	AUX
biomedich-816	40	12	crucial	crucial	ADJ
biomedich-816	40	13	for	for	ADP
biomedich-816	40	14	designing	design	VERB
biomedich-816	40	15	therapies	therapy	NOUN
biomedich-816	40	16	tailored	tailor	VERB
biomedich-816	40	17	to	to	ADP
biomedich-816	40	18	an	an	DET
biomedich-816	40	19	individual	individual	NOUN
biomedich-816	40	20	’s	’s	PART
biomedich-816	40	21	genetic	genetic	ADJ
biomedich-816	40	22	profile	profile	NOUN
biomedich-816	40	23	.	.	PUNCT
biomedich-816	41	1	therefore	therefore	ADV
biomedich-816	41	2	,	,	PUNCT
biomedich-816	41	3	multidisciplinary	multidisciplinary	ADJ
biomedich-816	41	4	collaboration	collaboration	NOUN
biomedich-816	41	5	between	between	ADP
biomedich-816	41	6	clinical	clinical	ADJ
biomedich-816	41	7	sciences	science	NOUN
biomedich-816	41	8	,	,	PUNCT
biomedich-816	41	9	environmental	environmental	ADJ
biomedich-816	41	10	toxicology	toxicology	NOUN
biomedich-816	41	11	,	,	PUNCT
biomedich-816	41	12	and	and	CCONJ
biomedich-816	41	13	bioinformatics	bioinformatics	NOUN
biomedich-816	41	14	is	be	AUX
biomedich-816	41	15	key	key	ADJ
biomedich-816	41	16	to	to	AUX
biomedich-816	41	17	comprehensively	comprehensively	ADV
biomedich-816	41	18	understanding	understand	VERB
biomedich-816	41	19	and	and	CCONJ
biomedich-816	41	20	managing	manage	VERB
biomedich-816	41	21	lung	lung	NOUN
biomedich-816	41	22	diseases	disease	NOUN
biomedich-816	41	23	caused	cause	VERB
biomedich-816	41	24	by	by	ADP
biomedich-816	41	25	external	external	ADJ
biomedich-816	41	26	agents	agent	NOUN
biomedich-816	41	27	(	(	PUNCT
biomedich-816	41	28	harber	harber	PROPN
biomedich-816	41	29	et	et	PROPN
biomedich-816	41	30	al	al	PROPN
biomedich-816	41	31	.	.	PROPN
biomedich-816	41	32	,	,	PUNCT
biomedich-816	41	33	2016	2016	NUM
biomedich-816	41	34	;	;	PUNCT
biomedich-816	41	35	he	he	PRON
biomedich-816	41	36	et	et	PROPN
biomedich-816	41	37	al	al	PROPN
biomedich-816	41	38	.	.	PROPN
biomedich-816	41	39	,	,	PUNCT
biomedich-816	41	40	2022	2022	NUM
biomedich-816	41	41	)	)	PUNCT
biomedich-816	41	42	.	.	PUNCT
biomedich-816	42	1	by	by	ADP
biomedich-816	42	2	elucidating	elucidate	VERB
biomedich-816	42	3	the	the	DET
biomedich-816	42	4	complex	complex	ADJ
biomedich-816	42	5	interplay	interplay	NOUN
biomedich-816	42	6	between	between	ADP
biomedich-816	42	7	environmental	environmental	ADJ
biomedich-816	42	8	and	and	CCONJ
biomedich-816	42	9	genetic	genetic	ADJ
biomedich-816	42	10	factors	factor	NOUN
biomedich-816	42	11	,	,	PUNCT
biomedich-816	42	12	we	we	PRON
biomedich-816	42	13	can	can	AUX
biomedich-816	42	14	pave	pave	VERB
biomedich-816	42	15	the	the	DET
biomedich-816	42	16	way	way	NOUN
biomedich-816	42	17	for	for	ADP
biomedich-816	42	18	more	more	ADV
biomedich-816	42	19	personalized	personalized	ADJ
biomedich-816	42	20	and	and	CCONJ
biomedich-816	42	21	effective	effective	ADJ
biomedich-816	42	22	prevention	prevention	NOUN
biomedich-816	42	23	and	and	CCONJ
biomedich-816	42	24	treatment	treatment	NOUN
biomedich-816	42	25	strategies	strategy	NOUN
biomedich-816	42	26	.	.	PUNCT
biomedich-816	43	1	this	this	DET
biomedich-816	43	2	study	study	NOUN
biomedich-816	43	3	aims	aim	VERB
biomedich-816	43	4	to	to	PART
biomedich-816	43	5	identify	identify	VERB
biomedich-816	43	6	and	and	CCONJ
biomedich-816	43	7	analyze	analyze	VERB
biomedich-816	43	8	genetic	genetic	ADJ
biomedich-816	43	9	variations	variation	NOUN
biomedich-816	43	10	(	(	PUNCT
biomedich-816	43	11	snps	snps	PROPN
biomedich-816	43	12	)	)	PUNCT
biomedich-816	43	13	that	that	PRON
biomedich-816	43	14	may	may	AUX
biomedich-816	43	15	increase	increase	VERB
biomedich-816	43	16	the	the	DET
biomedich-816	43	17	risk	risk	NOUN
biomedich-816	43	18	of	of	ADP
biomedich-816	43	19	lung	lung	NOUN
biomedich-816	43	20	disease	disease	NOUN
biomedich-816	43	21	due	due	ADP
biomedich-816	43	22	to	to	ADP
biomedich-816	43	23	exposure	exposure	NOUN
biomedich-816	43	24	to	to	ADP
biomedich-816	43	25	external	external	ADJ
biomedich-816	43	26	agents	agent	NOUN
biomedich-816	43	27	using	use	VERB
biomedich-816	43	28	a	a	DET
biomedich-816	43	29	bioinformatics	bioinformatics	NOUN
biomedich-816	43	30	approach	approach	NOUN
biomedich-816	43	31	.	.	PUNCT
biomedich-816	44	1	through	through	ADP
biomedich-816	44	2	this	this	DET
biomedich-816	44	3	research	research	NOUN
biomedich-816	44	4	,	,	PUNCT
biomedich-816	44	5	we	we	PRON
biomedich-816	44	6	hope	hope	VERB
biomedich-816	44	7	to	to	PART
biomedich-816	44	8	gain	gain	VERB
biomedich-816	44	9	a	a	DET
biomedich-816	44	10	more	more	ADV
biomedich-816	44	11	comprehensive	comprehensive	ADJ
biomedich-816	44	12	understanding	understanding	NOUN
biomedich-816	44	13	of	of	ADP
biomedich-816	44	14	the	the	DET
biomedich-816	44	15	relationship	relationship	NOUN
biomedich-816	44	16	between	between	ADP
biomedich-816	44	17	genetic	genetic	ADJ
biomedich-816	44	18	factors	factor	NOUN
biomedich-816	44	19	and	and	CCONJ
biomedich-816	44	20	environmental	environmental	ADJ
biomedich-816	44	21	exposures	exposure	NOUN
biomedich-816	44	22	in	in	ADP
biomedich-816	44	23	the	the	DET
biomedich-816	44	24	pathogenesis	pathogenesis	NOUN
biomedich-816	44	25	of	of	ADP
biomedich-816	44	26	lung	lung	NOUN
biomedich-816	44	27	diseases	disease	NOUN
biomedich-816	44	28	,	,	PUNCT
biomedich-816	44	29	thereby	thereby	ADV
biomedich-816	44	30	opening	open	VERB
biomedich-816	44	31	new	new	ADJ
biomedich-816	44	32	avenues	avenue	NOUN
biomedich-816	44	33	for	for	ADP
biomedich-816	44	34	the	the	DET
biomedich-816	44	35	development	development	NOUN
biomedich-816	44	36	of	of	ADP
biomedich-816	44	37	precision	precision	NOUN
biomedich-816	44	38	therapies	therapy	NOUN
biomedich-816	44	39	in	in	ADP
biomedich-816	44	40	the	the	DET
biomedich-816	44	41	future	future	NOUN
biomedich-816	44	42	.	.	PUNCT
biomedich-816	45	1	materials	material	NOUN
biomedich-816	45	2	and	and	CCONJ
biomedich-816	45	3	methods	method	NOUN
biomedich-816	45	4	this	this	DET
biomedich-816	45	5	study	study	NOUN
biomedich-816	45	6	employed	employ	VERB
biomedich-816	45	7	a	a	DET
biomedich-816	45	8	bioinformatics	bioinformatics	NOUN
biomedich-816	45	9	approach	approach	NOUN
biomedich-816	45	10	to	to	PART
biomedich-816	45	11	identify	identify	VERB
biomedich-816	45	12	genetic	genetic	ADJ
biomedich-816	45	13	variations	variation	NOUN
biomedich-816	45	14	that	that	PRON
biomedich-816	45	15	may	may	AUX
biomedich-816	45	16	increase	increase	VERB
biomedich-816	45	17	the	the	DET
biomedich-816	45	18	risk	risk	NOUN
biomedich-816	45	19	of	of	ADP
biomedich-816	45	20	lung	lung	NOUN
biomedich-816	45	21	disease	disease	NOUN
biomedich-816	45	22	due	due	ADP
biomedich-816	45	23	to	to	ADP
biomedich-816	45	24	exposure	exposure	NOUN
biomedich-816	45	25	to	to	ADP
biomedich-816	45	26	external	external	ADJ
biomedich-816	45	27	agents	agent	NOUN
biomedich-816	45	28	.	.	PUNCT
biomedich-816	46	1	the	the	DET
biomedich-816	46	2	analysis	analysis	NOUN
biomedich-816	46	3	was	be	AUX
biomedich-816	46	4	conducted	conduct	VERB
biomedich-816	46	5	through	through	ADP
biomedich-816	46	6	the	the	DET
biomedich-816	46	7	integration	integration	NOUN
biomedich-816	46	8	of	of	ADP
biomedich-816	46	9	various	various	ADJ
biomedich-816	46	10	publicly	publicly	ADV
biomedich-816	46	11	accessible	accessible	ADJ
biomedich-816	46	12	online	online	ADJ
biomedich-816	46	13	genetic	genetic	ADJ
biomedich-816	46	14	databases	database	NOUN
biomedich-816	46	15	,	,	PUNCT
biomedich-816	46	16	including	include	VERB
biomedich-816	46	17	the	the	DET
biomedich-816	46	18	gwas	gwas	PROPN
biomedich-816	46	19	catalog	catalog	NOUN
biomedich-816	46	20	,	,	PUNCT
biomedich-816	46	21	phewas	phewa	VERB
biomedich-816	46	22	resources	resource	NOUN
biomedich-816	46	23	,	,	PUNCT
biomedich-816	46	24	haploreg	haploreg	NOUN
biomedich-816	46	25	v4.2	v4.2	NOUN
biomedich-816	46	26	,	,	PUNCT
biomedich-816	46	27	gtex	gtex	PROPN
biomedich-816	46	28	portal	portal	NOUN
biomedich-816	46	29	,	,	PUNCT
biomedich-816	46	30	and	and	CCONJ
biomedich-816	46	31	the	the	DET
biomedich-816	46	32	ensembl	ensembl	NOUN
biomedich-816	46	33	genome	genome	NOUN
biomedich-816	46	34	browser	browser	NOUN
biomedich-816	46	35	.	.	PUNCT
biomedich-816	47	1	the	the	DET
biomedich-816	47	2	genome	genome	NOUN
biomedich-816	47	3	-	-	PUNCT
biomedich-816	47	4	wide	wide	ADJ
biomedich-816	47	5	association	association	NOUN
biomedich-816	47	6	studies	study	NOUN
biomedich-816	47	7	(	(	PUNCT
biomedich-816	47	8	gwas	gwas	PROPN
biomedich-816	47	9	)	)	PUNCT
biomedich-816	47	10	and	and	CCONJ
biomedich-816	47	11	phenome	phenome	ADJ
biomedich-816	47	12	-	-	PUNCT
biomedich-816	47	13	wide	wide	ADJ
biomedich-816	47	14	association	association	NOUN
biomedich-816	47	15	studies	study	NOUN
biomedich-816	47	16	(	(	PUNCT
biomedich-816	47	17	phewas	phewas	PROPN
biomedich-816	47	18	)	)	PUNCT
biomedich-816	47	19	databases	database	NOUN
biomedich-816	47	20	were	be	AUX
biomedich-816	47	21	used	use	VERB
biomedich-816	47	22	as	as	ADP
biomedich-816	47	23	primary	primary	ADJ
biomedich-816	47	24	resources	resource	NOUN
biomedich-816	47	25	to	to	PART
biomedich-816	47	26	identify	identify	VERB
biomedich-816	47	27	associations	association	NOUN
biomedich-816	47	28	between	between	ADP
biomedich-816	47	29	genetic	genetic	ADJ
biomedich-816	47	30	variants	variant	NOUN
biomedich-816	47	31	particularly	particularly	ADV
biomedich-816	47	32	single	single	ADJ
biomedich-816	47	33	nucleotide	nucleotide	ADJ
biomedich-816	47	34	polymorphisms	polymorphism	NOUN
biomedich-816	47	35	(	(	PUNCT
biomedich-816	47	36	snps	snps	PROPN
biomedich-816	47	37	)	)	PUNCT
biomedich-816	47	38	and	and	CCONJ
biomedich-816	47	39	various	various	ADJ
biomedich-816	47	40	disease	disease	NOUN
biomedich-816	47	41	phenotypes	phenotype	NOUN
biomedich-816	47	42	.	.	PUNCT
biomedich-816	48	1	since	since	SCONJ
biomedich-816	48	2	its	its	PRON
biomedich-816	48	3	development	development	NOUN
biomedich-816	48	4	by	by	ADP
biomedich-816	48	5	the	the	DET
biomedich-816	48	6	national	national	ADJ
biomedich-816	48	7	human	human	PROPN
biomedich-816	48	8	genome	genome	NOUN
biomedich-816	48	9	research	research	NOUN
biomedich-816	48	10	institute	institute	NOUN
biomedich-816	48	11	(	(	PUNCT
biomedich-816	48	12	nhgri	nhgri	ADJ
biomedich-816	48	13	)	)	PUNCT
biomedich-816	48	14	in	in	ADP
biomedich-816	48	15	2008	2008	NUM
biomedich-816	48	16	,	,	PUNCT
biomedich-816	48	17	the	the	DET
biomedich-816	48	18	gwas	gwas	PROPN
biomedich-816	48	19	catalog	catalog	NOUN
biomedich-816	48	20	has	have	AUX
biomedich-816	48	21	recorded	record	VERB
biomedich-816	48	22	over	over	ADP
biomedich-816	48	23	38,000	38,000	NUM
biomedich-816	48	24	associations	association	NOUN
biomedich-816	48	25	between	between	ADP
biomedich-816	48	26	snps	snps	PROPN
biomedich-816	48	27	and	and	CCONJ
biomedich-816	48	28	disease	disease	NOUN
biomedich-816	48	29	phenotypes	phenotype	NOUN
biomedich-816	48	30	,	,	PUNCT
biomedich-816	48	31	including	include	VERB
biomedich-816	48	32	information	information	NOUN
biomedich-816	48	33	about	about	ADP
biomedich-816	48	34	the	the	DET
biomedich-816	48	35	involved	involved	ADJ
biomedich-816	48	36	polymorphic	polymorphic	ADJ
biomedich-816	48	37	alleles	allele	NOUN
biomedich-816	48	38	(	(	PUNCT
biomedich-816	48	39	burbelo	burbelo	X
biomedich-816	48	40	et	et	PROPN
biomedich-816	48	41	al	al	PROPN
biomedich-816	48	42	.	.	PROPN
biomedich-816	48	43	,	,	PUNCT
biomedich-816	48	44	2014	2014	NUM
biomedich-816	48	45	)	)	PUNCT
biomedich-816	48	46	.	.	PUNCT
biomedich-816	49	1	meanwhile	meanwhile	ADV
biomedich-816	49	2	,	,	PUNCT
biomedich-816	49	3	the	the	DET
biomedich-816	49	4	phewas	phewas	PROPN
biomedich-816	49	5	database	database	NOUN
biomedich-816	49	6	provides	provide	VERB
biomedich-816	49	7	data	datum	NOUN
biomedich-816	49	8	on	on	ADP
biomedich-816	49	9	the	the	DET
biomedich-816	49	10	relationships	relationship	NOUN
biomedich-816	49	11	between	between	ADP
biomedich-816	49	12	over	over	ADP
biomedich-816	49	13	3,000	3,000	NUM
biomedich-816	49	14	snps	snps	NOUN
biomedich-816	49	15	and	and	CCONJ
biomedich-816	49	16	diverse	diverse	VERB
biomedich-816	49	17	clinical	clinical	ADJ
biomedich-816	49	18	manifestations	manifestation	NOUN
biomedich-816	49	19	,	,	PUNCT
biomedich-816	49	20	making	make	VERB
biomedich-816	49	21	it	it	PRON
biomedich-816	49	22	a	a	DET
biomedich-816	49	23	valuable	valuable	ADJ
biomedich-816	49	24	tool	tool	NOUN
biomedich-816	49	25	for	for	ADP
biomedich-816	49	26	exploring	explore	VERB
biomedich-816	49	27	genotype	genotype	NOUN
biomedich-816	49	28	-	-	PUNCT
biomedich-816	49	29	phenotype	phenotype	NOUN
biomedich-816	49	30	associations	association	NOUN
biomedich-816	49	31	on	on	ADP
biomedich-816	49	32	a	a	DET
biomedich-816	49	33	broad	broad	ADJ
biomedich-816	49	34	scale	scale	NOUN
biomedich-816	49	35	(	(	PUNCT
biomedich-816	49	36	pendergrass	pendergrass	PROPN
biomedich-816	49	37	et	et	PROPN
biomedich-816	49	38	al	al	PROPN
biomedich-816	49	39	.	.	PROPN
biomedich-816	49	40	,	,	PUNCT
biomedich-816	49	41	2012	2012	NUM
biomedich-816	49	42	)	)	PUNCT
biomedich-816	49	43	.	.	PUNCT
biomedich-816	50	1	in	in	ADP
biomedich-816	50	2	the	the	DET
biomedich-816	50	3	initial	initial	ADJ
biomedich-816	50	4	phase	phase	NOUN
biomedich-816	50	5	of	of	ADP
biomedich-816	50	6	the	the	DET
biomedich-816	50	7	analysis	analysis	NOUN
biomedich-816	50	8	,	,	PUNCT
biomedich-816	50	9	snps	snps	PROPN
biomedich-816	50	10	potentially	potentially	ADV
biomedich-816	50	11	associated	associate	VERB
biomedich-816	50	12	with	with	ADP
biomedich-816	50	13	increased	increase	VERB
biomedich-816	50	14	risk	risk	NOUN
biomedich-816	50	15	of	of	ADP
biomedich-816	50	16	lung	lung	NOUN
biomedich-816	50	17	disease	disease	NOUN
biomedich-816	50	18	due	due	ADP
biomedich-816	50	19	to	to	ADP
biomedich-816	50	20	environmental	environmental	ADJ
biomedich-816	50	21	exposure	exposure	NOUN
biomedich-816	50	22	were	be	AUX
biomedich-816	50	23	identified	identify	VERB
biomedich-816	50	24	using	use	VERB
biomedich-816	50	25	phewas	phewa	VERB
biomedich-816	50	26	resources	resource	NOUN
biomedich-816	50	27	.	.	PUNCT
biomedich-816	51	1	selection	selection	NOUN
biomedich-816	51	2	of	of	ADP
biomedich-816	51	3	snps	snps	PROPN
biomedich-816	51	4	was	be	AUX
biomedich-816	51	5	based	base	VERB
biomedich-816	51	6	on	on	ADP
biomedich-816	51	7	a	a	DET
biomedich-816	51	8	significance	significance	NOUN
biomedich-816	51	9	threshold	threshold	NOUN
biomedich-816	51	10	of	of	ADP
biomedich-816	51	11	p	p	NOUN
biomedich-816	51	12	-	-	PUNCT
biomedich-816	51	13	value	value	NOUN
biomedich-816	51	14	<	<	NOUN
biomedich-816	51	15	0.05	0.05	NUM
biomedich-816	51	16	and	and	CCONJ
biomedich-816	51	17	an	an	DET
biomedich-816	51	18	odds	odd	NOUN
biomedich-816	51	19	ratio	ratio	NOUN
biomedich-816	51	20	(	(	PUNCT
biomedich-816	51	21	or	or	CCONJ
biomedich-816	51	22	)	)	PUNCT
biomedich-816	51	23	>	>	X
biomedich-816	52	1	1	1	NUM
biomedich-816	52	2	,	,	PUNCT
biomedich-816	52	3	indicating	indicate	VERB
biomedich-816	52	4	a	a	DET
biomedich-816	52	5	statistically	statistically	ADV
biomedich-816	52	6	meaningful	meaningful	ADJ
biomedich-816	52	7	increase	increase	NOUN
biomedich-816	52	8	in	in	ADP
biomedich-816	52	9	disease	disease	NOUN
biomedich-816	52	10	risk	risk	NOUN
biomedich-816	52	11	.	.	PUNCT
biomedich-816	53	1	snps	snps	PROPN
biomedich-816	53	2	meeting	meet	VERB
biomedich-816	53	3	these	these	DET
biomedich-816	53	4	criteria	criterion	NOUN
biomedich-816	53	5	were	be	AUX
biomedich-816	53	6	then	then	ADV
biomedich-816	53	7	further	far	ADV
biomedich-816	53	8	analyzed	analyze	VERB
biomedich-816	53	9	to	to	PART
biomedich-816	53	10	determine	determine	VERB
biomedich-816	53	11	the	the	DET
biomedich-816	53	12	presence	presence	NOUN
biomedich-816	53	13	of	of	ADP
biomedich-816	53	14	missense	missense	NOUN
biomedich-816	53	15	mutations	mutation	NOUN
biomedich-816	53	16	,	,	PUNCT
biomedich-816	53	17	which	which	PRON
biomedich-816	53	18	refer	refer	VERB
biomedich-816	53	19	to	to	ADP
biomedich-816	53	20	codon	codon	ADJ
biomedich-816	53	21	changes	change	NOUN
biomedich-816	53	22	resulting	result	VERB
biomedich-816	53	23	in	in	ADP
biomedich-816	53	24	amino	amino	NOUN
biomedich-816	53	25	acid	acid	NOUN
biomedich-816	53	26	substitutions	substitution	NOUN
biomedich-816	53	27	(	(	PUNCT
biomedich-816	53	28	irham	irham	PROPN
biomedich-816	53	29	et	et	PROPN
biomedich-816	53	30	al	al	PROPN
biomedich-816	53	31	.	.	PROPN
biomedich-816	53	32	,	,	PUNCT
biomedich-816	53	33	2023	2023	NUM
biomedich-816	53	34	)	)	PUNCT
biomedich-816	53	35	.	.	PUNCT
biomedich-816	54	1	this	this	DET
biomedich-816	54	2	analysis	analysis	NOUN
biomedich-816	54	3	was	be	AUX
biomedich-816	54	4	conducted	conduct	VERB
biomedich-816	54	5	using	use	VERB
biomedich-816	54	6	haploreg	haploreg	NOUN
biomedich-816	54	7	v4.2	v4.2	NOUN
biomedich-816	54	8	,	,	PUNCT
biomedich-816	54	9	which	which	PRON
biomedich-816	54	10	provides	provide	VERB
biomedich-816	54	11	in	in	ADP
biomedich-816	54	12	-	-	PUNCT
biomedich-816	54	13	depth	depth	NOUN
biomedich-816	54	14	information	information	NOUN
biomedich-816	54	15	on	on	ADP
biomedich-816	54	16	structural	structural	ADJ
biomedich-816	54	17	genetic	genetic	ADJ
biomedich-816	54	18	variations	variation	NOUN
biomedich-816	54	19	and	and	CCONJ
biomedich-816	54	20	epigenetic	epigenetic	ADJ
biomedich-816	54	21	regulatory	regulatory	ADJ
biomedich-816	54	22	features	feature	NOUN
biomedich-816	54	23	.	.	PUNCT
biomedich-816	55	1	snps	snps	PROPN
biomedich-816	55	2	with	with	ADP
biomedich-816	55	3	identified	identify	VERB
biomedich-816	55	4	missense	missense	NOUN
biomedich-816	55	5	mutations	mutation	NOUN
biomedich-816	55	6	were	be	AUX
biomedich-816	55	7	subsequently	subsequently	ADV
biomedich-816	55	8	evaluated	evaluate	VERB
biomedich-816	55	9	for	for	ADP
biomedich-816	55	10	their	their	PRON
biomedich-816	55	11	expression	expression	NOUN
biomedich-816	55	12	in	in	ADP
biomedich-816	55	13	lung	lung	NOUN
biomedich-816	55	14	tissue	tissue	NOUN
biomedich-816	55	15	using	use	VERB
biomedich-816	55	16	data	datum	NOUN
biomedich-816	55	17	from	from	ADP
biomedich-816	55	18	the	the	DET
biomedich-816	55	19	gtex	gtex	PROPN
biomedich-816	55	20	portal	portal	PROPN
biomedich-816	55	21	.	.	PUNCT
biomedich-816	56	1	the	the	DET
biomedich-816	56	2	genotype	genotype	NOUN
biomedich-816	56	3	-	-	PUNCT
biomedich-816	56	4	tissue	tissue	NOUN
biomedich-816	56	5	expression	expression	NOUN
biomedich-816	56	6	(	(	PUNCT
biomedich-816	56	7	gtex	gtex	NOUN
biomedich-816	56	8	)	)	PUNCT
biomedich-816	56	9	project	project	NOUN
biomedich-816	56	10	offers	offer	VERB
biomedich-816	56	11	comprehensive	comprehensive	ADJ
biomedich-816	56	12	data	datum	NOUN
biomedich-816	56	13	on	on	ADP
biomedich-816	56	14	correlations	correlation	NOUN
biomedich-816	56	15	between	between	ADP
biomedich-816	56	16	genetic	genetic	ADJ
biomedich-816	56	17	variants	variant	NOUN
biomedich-816	56	18	and	and	CCONJ
biomedich-816	56	19	gene	gene	NOUN
biomedich-816	56	20	expression	expression	NOUN
biomedich-816	56	21	levels	level	NOUN
biomedich-816	56	22	across	across	ADP
biomedich-816	56	23	various	various	ADJ
biomedich-816	56	24	human	human	ADJ
biomedich-816	56	25	tissues	tissue	NOUN
biomedich-816	56	26	,	,	PUNCT
biomedich-816	56	27	including	include	VERB
biomedich-816	56	28	the	the	DET
biomedich-816	56	29	lungs	lung	NOUN
biomedich-816	56	30	.	.	PUNCT
biomedich-816	57	1	this	this	DET
biomedich-816	57	2	expression	expression	NOUN
biomedich-816	57	3	analysis	analysis	NOUN
biomedich-816	57	4	,	,	PUNCT
biomedich-816	57	5	based	base	VERB
biomedich-816	57	6	on	on	ADP
biomedich-816	57	7	expression	expression	NOUN
biomedich-816	57	8	quantitative	quantitative	ADJ
biomedich-816	57	9	trait	trait	NOUN
biomedich-816	57	10	locus	locus	NOUN
biomedich-816	57	11	(	(	PUNCT
biomedich-816	57	12	eqtl	eqtl	NOUN
biomedich-816	57	13	)	)	PUNCT
biomedich-816	57	14	data	datum	NOUN
biomedich-816	57	15	,	,	PUNCT
biomedich-816	57	16	is	be	AUX
biomedich-816	57	17	crucial	crucial	ADJ
biomedich-816	57	18	for	for	ADP
biomedich-816	57	19	identifying	identify	VERB
biomedich-816	57	20	variants	variant	NOUN
biomedich-816	57	21	that	that	PRON
biomedich-816	57	22	are	be	AUX
biomedich-816	57	23	not	not	PART
biomedich-816	57	24	only	only	ADV
biomedich-816	57	25	structural	structural	ADJ
biomedich-816	57	26	but	but	CCONJ
biomedich-816	57	27	also	also	ADV
biomedich-816	57	28	functionally	functionally	ADV
biomedich-816	57	29	significant	significant	ADJ
biomedich-816	57	30	in	in	ADP
biomedich-816	57	31	modulating	modulate	VERB
biomedich-816	57	32	gene	gene	NOUN
biomedich-816	57	33	activity	activity	NOUN
biomedich-816	57	34	within	within	ADP
biomedich-816	57	35	the	the	DET
biomedich-816	57	36	target	target	NOUN
biomedich-816	57	37	tissue	tissue	NOUN
biomedich-816	57	38	(	(	PUNCT
biomedich-816	57	39	ma’ruf	ma’ruf	NOUN
biomedich-816	57	40	et	et	PROPN
biomedich-816	57	41	al	al	PROPN
biomedich-816	57	42	.	.	PROPN
biomedich-816	57	43	,	,	PUNCT
biomedich-816	57	44	2023	2023	NUM
biomedich-816	57	45	)	)	PUNCT
biomedich-816	57	46	.	.	PUNCT
biomedich-816	58	1	as	as	ADP
biomedich-816	58	2	a	a	DET
biomedich-816	58	3	final	final	ADJ
biomedich-816	58	4	step	step	NOUN
biomedich-816	58	5	,	,	PUNCT
biomedich-816	58	6	the	the	DET
biomedich-816	58	7	population	population	NOUN
biomedich-816	58	8	distribution	distribution	NOUN
biomedich-816	58	9	of	of	ADP
biomedich-816	58	10	the	the	DET
biomedich-816	58	11	identified	identify	VERB
biomedich-816	58	12	genetic	genetic	ADJ
biomedich-816	58	13	variants	variant	NOUN
biomedich-816	58	14	was	be	AUX
biomedich-816	58	15	analyzed	analyze	VERB
biomedich-816	58	16	using	use	VERB
biomedich-816	58	17	the	the	DET
biomedich-816	58	18	ensembl	ensembl	NOUN
biomedich-816	58	19	genome	genome	NOUN
biomedich-816	58	20	browser	browser	NOUN
biomedich-816	58	21	(	(	PUNCT
biomedich-816	58	22	ensembl	ensembl	NOUN
biomedich-816	58	23	genome	genome	NOUN
biomedich-816	58	24	browser	browser	NOUN
biomedich-816	58	25	113	113	NUM
biomedich-816	58	26	)	)	PUNCT
biomedich-816	58	27	.	.	PUNCT
biomedich-816	59	1	this	this	DET
biomedich-816	59	2	database	database	NOUN
biomedich-816	59	3	provides	provide	VERB
biomedich-816	59	4	allele	allele	NOUN
biomedich-816	59	5	frequency	frequency	NOUN
biomedich-816	59	6	data	datum	NOUN
biomedich-816	59	7	across	across	ADP
biomedich-816	59	8	diverse	diverse	ADJ
biomedich-816	59	9	global	global	ADJ
biomedich-816	59	10	populations	population	NOUN
biomedich-816	59	11	,	,	PUNCT
biomedich-816	59	12	including	include	VERB
biomedich-816	59	13	those	those	PRON
biomedich-816	59	14	from	from	ADP
biomedich-816	59	15	the	the	DET
biomedich-816	59	16	americas	americas	PROPN
biomedich-816	59	17	,	,	PUNCT
biomedich-816	59	18	africa	africa	PROPN
biomedich-816	59	19	,	,	PUNCT
biomedich-816	59	20	europe	europe	PROPN
biomedich-816	59	21	,	,	PUNCT
biomedich-816	59	22	east	east	PROPN
biomedich-816	59	23	asia	asia	PROPN
biomedich-816	59	24	,	,	PUNCT
biomedich-816	59	25	and	and	CCONJ
biomedich-816	59	26	south	south	PROPN
biomedich-816	59	27	asia	asia	PROPN
biomedich-816	59	28	(	(	PUNCT
biomedich-816	59	29	ma’ruf	ma’ruf	NOUN
biomedich-816	59	30	et	et	PROPN
biomedich-816	59	31	al	al	PROPN
biomedich-816	59	32	.	.	PROPN
biomedich-816	59	33	,	,	PUNCT
biomedich-816	59	34	2023	2023	NUM
biomedich-816	59	35	)	)	PUNCT
biomedich-816	59	36	.	.	PUNCT
biomedich-816	60	1	this	this	DET
biomedich-816	60	2	information	information	NOUN
biomedich-816	60	3	is	be	AUX
biomedich-816	60	4	valuable	valuable	ADJ
biomedich-816	60	5	for	for	ADP
biomedich-816	60	6	understanding	understand	VERB
biomedich-816	60	7	the	the	DET
biomedich-816	60	8	geographical	geographical	ADJ
biomedich-816	60	9	and	and	CCONJ
biomedich-816	60	10	ethnic	ethnic	ADJ
biomedich-816	60	11	distribution	distribution	NOUN
biomedich-816	60	12	of	of	ADP
biomedich-816	60	13	genetic	genetic	ADJ
biomedich-816	60	14	risk	risk	NOUN
biomedich-816	60	15	factors	factor	NOUN
biomedich-816	60	16	and	and	CCONJ
biomedich-816	60	17	their	their	PRON
biomedich-816	60	18	potential	potential	ADJ
biomedich-816	60	19	public	public	ADJ
biomedich-816	60	20	health	health	NOUN
biomedich-816	60	21	implications	implication	NOUN
biomedich-816	60	22	across	across	ADP
biomedich-816	60	23	different	different	ADJ
biomedich-816	60	24	regions	region	NOUN
biomedich-816	60	25	.	.	PUNCT
biomedich-816	61	1	farid	farid	PROPN
biomedich-816	61	2	et	et	PROPN
biomedich-816	61	3	al	al	PROPN
biomedich-816	61	4	.	.	PROPN
biomedich-816	61	5	–	–	PUNCT
biomedich-816	61	6	investigating	investigate	VERB
biomedich-816	61	7	genetic	genetic	ADJ
biomedich-816	61	8	vulnerability	vulnerability	NOUN
biomedich-816	61	9	to	to	ADP
biomedich-816	61	10	environmental	environmental	ADJ
biomedich-816	61	11	exposures	exposure	NOUN
biomedich-816	61	12	…	…	PUNCT
biomedich-816	61	13	719	719	NUM
biomedich-816	61	14	results	result	NOUN
biomedich-816	61	15	and	and	CCONJ
biomedich-816	61	16	discussion	discussion	VERB
biomedich-816	61	17	the	the	DET
biomedich-816	61	18	initial	initial	ADJ
biomedich-816	61	19	phase	phase	NOUN
biomedich-816	61	20	of	of	ADP
biomedich-816	61	21	this	this	DET
biomedich-816	61	22	study	study	NOUN
biomedich-816	61	23	involved	involve	VERB
biomedich-816	61	24	the	the	DET
biomedich-816	61	25	identification	identification	NOUN
biomedich-816	61	26	of	of	ADP
biomedich-816	61	27	single	single	ADJ
biomedich-816	61	28	nucleotide	nucleotide	ADJ
biomedich-816	61	29	polymorphisms	polymorphism	NOUN
biomedich-816	61	30	(	(	PUNCT
biomedich-816	61	31	snps	snps	PROPN
biomedich-816	61	32	)	)	PUNCT
biomedich-816	61	33	potentially	potentially	ADV
biomedich-816	61	34	contributing	contribute	VERB
biomedich-816	61	35	to	to	ADP
biomedich-816	61	36	increased	increase	VERB
biomedich-816	61	37	risk	risk	NOUN
biomedich-816	61	38	of	of	ADP
biomedich-816	61	39	lung	lung	NOUN
biomedich-816	61	40	disease	disease	NOUN
biomedich-816	61	41	due	due	ADP
biomedich-816	61	42	to	to	ADP
biomedich-816	61	43	exposure	exposure	NOUN
biomedich-816	61	44	to	to	ADP
biomedich-816	61	45	external	external	ADJ
biomedich-816	61	46	agents	agent	NOUN
biomedich-816	61	47	.	.	PUNCT
biomedich-816	62	1	this	this	DET
biomedich-816	62	2	process	process	NOUN
biomedich-816	62	3	was	be	AUX
biomedich-816	62	4	carried	carry	VERB
biomedich-816	62	5	out	out	ADP
biomedich-816	62	6	using	use	VERB
biomedich-816	62	7	the	the	DET
biomedich-816	62	8	phewas	phewas	PROPN
biomedich-816	62	9	database	database	NOUN
biomedich-816	62	10	,	,	PUNCT
biomedich-816	62	11	which	which	PRON
biomedich-816	62	12	yielded	yield	VERB
biomedich-816	62	13	an	an	DET
biomedich-816	62	14	initial	initial	ADJ
biomedich-816	62	15	list	list	NOUN
biomedich-816	62	16	of	of	ADP
biomedich-816	62	17	151	151	NUM
biomedich-816	62	18	snps	snp	NOUN
biomedich-816	62	19	potentially	potentially	ADV
biomedich-816	62	20	associated	associate	VERB
biomedich-816	62	21	with	with	ADP
biomedich-816	62	22	pathological	pathological	ADJ
biomedich-816	62	23	conditions	condition	NOUN
biomedich-816	62	24	in	in	ADP
biomedich-816	62	25	lung	lung	NOUN
biomedich-816	62	26	tissue	tissue	NOUN
biomedich-816	62	27	.	.	PUNCT
biomedich-816	63	1	to	to	PART
biomedich-816	63	2	refine	refine	VERB
biomedich-816	63	3	the	the	DET
biomedich-816	63	4	scope	scope	NOUN
biomedich-816	63	5	of	of	ADP
biomedich-816	63	6	analysis	analysis	NOUN
biomedich-816	63	7	and	and	CCONJ
biomedich-816	63	8	ensure	ensure	VERB
biomedich-816	63	9	statistical	statistical	ADJ
biomedich-816	63	10	significance	significance	NOUN
biomedich-816	63	11	,	,	PUNCT
biomedich-816	63	12	a	a	DET
biomedich-816	63	13	filtering	filter	VERB
biomedich-816	63	14	process	process	NOUN
biomedich-816	63	15	was	be	AUX
biomedich-816	63	16	applied	apply	VERB
biomedich-816	63	17	based	base	VERB
biomedich-816	63	18	on	on	ADP
biomedich-816	63	19	the	the	DET
biomedich-816	63	20	criteria	criterion	NOUN
biomedich-816	63	21	of	of	ADP
biomedich-816	63	22	p	p	NOUN
biomedich-816	63	23	-	-	PUNCT
biomedich-816	63	24	value	value	NOUN
biomedich-816	63	25	<	<	NOUN
biomedich-816	63	26	0.05	0.05	NUM
biomedich-816	63	27	and	and	CCONJ
biomedich-816	63	28	odds	odd	NOUN
biomedich-816	63	29	ratio	ratio	NOUN
biomedich-816	63	30	(	(	PUNCT
biomedich-816	63	31	or	or	CCONJ
biomedich-816	63	32	)	)	PUNCT
biomedich-816	63	33	>	>	X
biomedich-816	64	1	1	1	X
biomedich-816	64	2	.	.	PUNCT
biomedich-816	65	1	this	this	DET
biomedich-816	65	2	filtering	filtering	NOUN
biomedich-816	65	3	resulted	result	VERB
biomedich-816	65	4	in	in	ADP
biomedich-816	65	5	86	86	NUM
biomedich-816	65	6	snps	snps	NOUN
biomedich-816	65	7	that	that	PRON
biomedich-816	65	8	met	meet	VERB
biomedich-816	65	9	the	the	DET
biomedich-816	65	10	criteria	criterion	NOUN
biomedich-816	65	11	and	and	CCONJ
biomedich-816	65	12	were	be	AUX
biomedich-816	65	13	considered	consider	VERB
biomedich-816	65	14	to	to	PART
biomedich-816	65	15	have	have	VERB
biomedich-816	65	16	significant	significant	ADJ
biomedich-816	65	17	mutational	mutational	ADJ
biomedich-816	65	18	potential	potential	NOUN
biomedich-816	65	19	.	.	PUNCT
biomedich-816	66	1	details	detail	NOUN
biomedich-816	66	2	of	of	ADP
biomedich-816	66	3	these	these	DET
biomedich-816	66	4	snps	snps	PROPN
biomedich-816	66	5	are	be	AUX
biomedich-816	66	6	presented	present	VERB
biomedich-816	66	7	in	in	ADP
biomedich-816	66	8	table	table	NOUN
biomedich-816	66	9	1	1	NUM
biomedich-816	66	10	.	.	PUNCT
biomedich-816	66	11	table	table	NOUN
biomedich-816	66	12	1	1	NUM
biomedich-816	66	13	.	.	X
biomedich-816	67	1	snps	snps	PROPN
biomedich-816	67	2	form	form	VERB
biomedich-816	67	3	phewas	phewa	VERB
biomedich-816	67	4	database	database	NOUN
biomedich-816	67	5	.	.	PUNCT
biomedich-816	68	1	snp	snp	PROPN
biomedich-816	68	2	p	p	NOUN
biomedich-816	68	3	-	-	PUNCT
biomedich-816	68	4	value	value	NOUN
biomedich-816	68	5	odds	odd	NOUN
biomedich-816	68	6	-	-	PUNCT
biomedich-816	68	7	ratio	ratio	NOUN
biomedich-816	68	8	snp	snp	ADJ
biomedich-816	68	9	p	p	NOUN
biomedich-816	68	10	-	-	PUNCT
biomedich-816	68	11	value	value	NOUN
biomedich-816	68	12	odds	odd	NOUN
biomedich-816	68	13	-	-	PUNCT
biomedich-816	68	14	ratio	ratio	NOUN
biomedich-816	68	15	snp	snp	ADJ
biomedich-816	68	16	p	p	NOUN
biomedich-816	68	17	-	-	PUNCT
biomedich-816	68	18	value	value	NOUN
biomedich-816	68	19	odds	odd	NOUN
biomedich-816	68	20	-	-	PUNCT
biomedich-816	68	21	ratio	ratio	NOUN
biomedich-816	68	22	rs2006996	rs2006996	NOUN
biomedich-816	68	23	0.0009142	0.0009142	NUM
biomedich-816	68	24	2.379	2.379	NUM
biomedich-816	68	25	rs6704644	rs6704644	VERB
biomedich-816	68	26	0.03987	0.03987	NUM
biomedich-816	68	27	1.6	1.6	NUM
biomedich-816	68	28	rs744910	rs744910	NOUN
biomedich-816	68	29	0.02215	0.02215	NUM
biomedich-816	68	30	1.455	1.455	NUM
biomedich-816	68	31	rs2237878	rs2237878	ADJ
biomedich-816	68	32	0.0001304	0.0001304	NUM
biomedich-816	68	33	2.179	2.179	NUM
biomedich-816	68	34	rs2237886	rs2237886	NOUN
biomedich-816	68	35	0.03513	0.03513	NUM
biomedich-816	68	36	1.598	1.598	NUM
biomedich-816	68	37	rs727957	rs727957	NOUN
biomedich-816	68	38	0.03989	0.03989	NUM
biomedich-816	68	39	1.455	1.455	NUM
biomedich-816	68	40	rs1800961	rs1800961	PROPN
biomedich-816	68	41	0.02108	0.02108	NUM
biomedich-816	68	42	2.075	2.075	NUM
biomedich-816	68	43	rs1408282	rs1408282	PROPN
biomedich-816	68	44	0.04102	0.04102	NUM
biomedich-816	68	45	1.581	1.581	NUM
biomedich-816	68	46	rs1836127	rs1836127	NOUN
biomedich-816	68	47	0.01948	0.01948	NUM
biomedich-816	68	48	1.45	1.45	NUM
biomedich-816	68	49	rs544368	rs544368	NOUN
biomedich-816	68	50	0.0005663	0.0005663	NUM
biomedich-816	68	51	1.97	1.97	NUM
biomedich-816	68	52	rs12134279	rs12134279	NOUN
biomedich-816	68	53	0.01145	0.01145	NUM
biomedich-816	68	54	1.577	1.577	NUM
biomedich-816	68	55	rs10744304	rs10744304	ADJ
biomedich-816	68	56	0.0209	0.0209	NUM
biomedich-816	68	57	1.449	1.449	NUM
biomedich-816	68	58	rs7702057	rs7702057	NOUN
biomedich-816	68	59	0.04517	0.04517	NUM
biomedich-816	68	60	1.917	1.917	NUM
biomedich-816	68	61	rs3099844	rs3099844	NOUN
biomedich-816	68	62	0.032	0.032	NUM
biomedich-816	68	63	1.57	1.57	NUM
biomedich-816	68	64	rs11031093	rs11031093	PROPN
biomedich-816	68	65	0.02643	0.02643	NUM
biomedich-816	68	66	1.44	1.44	NUM
biomedich-816	68	67	rs737337	rs737337	NOUN
biomedich-816	68	68	0.008276	0.008276	NUM
biomedich-816	68	69	1.814	1.814	NUM
biomedich-816	68	70	rs3131296	rs3131296	NOUN
biomedich-816	68	71	0.02662	0.02662	NUM
biomedich-816	68	72	1.567	1.567	NUM
biomedich-816	68	73	rs1927745	rs1927745	VERB
biomedich-816	68	74	0.03301	0.03301	NUM
biomedich-816	68	75	1.436	1.436	NUM
biomedich-816	68	76	rs12534221	rs12534221	NOUN
biomedich-816	68	77	0.002788	0.002788	NUM
biomedich-816	68	78	1.739	1.739	NUM
biomedich-816	68	79	rs8321	rs8321	NOUN
biomedich-816	68	80	0.04864	0.04864	NUM
biomedich-816	68	81	1.56	1.56	NUM
biomedich-816	68	82	rs10737562	rs10737562	NOUN
biomedich-816	68	83	0.02732	0.02732	NUM
biomedich-816	68	84	1.431	1.431	NUM
biomedich-816	68	85	rs12317459	rs12317459	NOUN
biomedich-816	68	86	0.001874	0.001874	NUM
biomedich-816	68	87	1.731	1.731	NUM
biomedich-816	68	88	rs771767	rs771767	ADJ
biomedich-816	68	89	0.007037	0.007037	NUM
biomedich-816	68	90	1.559	1.559	NUM
biomedich-816	68	91	rs1000579	rs1000579	NOUN
biomedich-816	68	92	0.02406	0.02406	NUM
biomedich-816	68	93	1.43	1.43	NUM
biomedich-816	68	94	rs2233287	rs2233287	NOUN
biomedich-816	68	95	0.01872	0.01872	NUM
biomedich-816	68	96	1.703	1.703	NUM
biomedich-816	68	97	rs8023445	rs8023445	NOUN
biomedich-816	68	98	0.04503	0.04503	NUM
biomedich-816	68	99	1.556	1.556	NUM
biomedich-816	68	100	rs2248359	rs2248359	NOUN
biomedich-816	68	101	0.02413	0.02413	NUM
biomedich-816	68	102	1.428	1.428	NUM
biomedich-816	68	103	rs11618202	rs11618202	ADJ
biomedich-816	68	104	0.02869	0.02869	NUM
biomedich-816	68	105	1.696	1.696	NUM
biomedich-816	68	106	rs17111394	rs17111394	NOUN
biomedich-816	68	107	0.01972	0.01972	NUM
biomedich-816	68	108	1.545	1.545	NUM
biomedich-816	68	109	rs2208059	rs2208059	NOUN
biomedich-816	68	110	0.02464	0.02464	NUM
biomedich-816	68	111	1.428	1.428	NUM
biomedich-816	68	112	rs13376333	rs13376333	NOUN
biomedich-816	68	113	0.000899	0.000899	NUM
biomedich-816	68	114	1.692	1.692	NUM
biomedich-816	68	115	rs649891	rs649891	NOUN
biomedich-816	68	116	0.01776	0.01776	NUM
biomedich-816	68	117	1.538	1.538	NUM
biomedich-816	68	118	rs927675	rs927675	NOUN
biomedich-816	68	119	0.02681	0.02681	NUM
biomedich-816	68	120	1.425	1.425	NUM
biomedich-816	68	121	rs4952590	rs4952590	NOUN
biomedich-816	68	122	0.01132	0.01132	NUM
biomedich-816	68	123	1.692	1.692	NUM
biomedich-816	68	124	rs6478108	rs6478108	NOUN
biomedich-816	68	125	0.006956	0.006956	NUM
biomedich-816	68	126	1.534	1.534	NUM
biomedich-816	68	127	rs7072268	rs7072268	NOUN
biomedich-816	68	128	0.02769	0.02769	NUM
biomedich-816	68	129	1.423	1.423	NUM
biomedich-816	68	130	rs6683071	rs6683071	PROPN
biomedich-816	68	131	0.004638	0.004638	NUM
biomedich-816	68	132	1.677	1.677	NUM
biomedich-816	68	133	rs10475598	rs10475598	NOUN
biomedich-816	68	134	0.009451	0.009451	NUM
biomedich-816	68	135	1.53	1.53	NUM
biomedich-816	68	136	rs2239633	rs2239633	NOUN
biomedich-816	68	137	0.02709	0.02709	NUM
biomedich-816	68	138	1.422	1.422	NUM
biomedich-816	68	139	rs3131379	rs3131379	ADJ
biomedich-816	68	140	0.02038	0.02038	NUM
biomedich-816	68	141	1.665	1.665	NUM
biomedich-816	68	142	rs12727642	rs12727642	PROPN
biomedich-816	68	143	0.0292	0.0292	NUM
biomedich-816	68	144	1.523	1.523	NUM
biomedich-816	68	145	rs153734	rs153734	NOUN
biomedich-816	68	146	0.04868	0.04868	NUM
biomedich-816	68	147	1.422	1.422	NUM
biomedich-816	68	148	rs10488031	rs10488031	NOUN
biomedich-816	68	149	0.04744	0.04744	NUM
biomedich-816	68	150	1.665	1.665	NUM
biomedich-816	68	151	rs1574192	rs1574192	NOUN
biomedich-816	68	152	0.008351	0.008351	NUM
biomedich-816	68	153	1.522	1.522	NUM
biomedich-816	68	154	rs204993	rs204993	NOUN
biomedich-816	68	155	0.04138	0.04138	NUM
biomedich-816	68	156	1.42	1.42	NUM
biomedich-816	68	157	rs3117582	rs3117582	NOUN
biomedich-816	68	158	0.02062	0.02062	NUM
biomedich-816	68	159	1.662	1.662	NUM
biomedich-816	68	160	rs2068888	rs2068888	NOUN
biomedich-816	68	161	0.009902	0.009902	NUM
biomedich-816	68	162	1.517	1.517	NUM
biomedich-816	68	163	rs697739	rs697739	NOUN
biomedich-816	68	164	0.03235	0.03235	NUM
biomedich-816	68	165	1.417	1.417	NUM
biomedich-816	68	166	rs1549519	rs1549519	NOUN
biomedich-816	68	167	0.007362	0.007362	NUM
biomedich-816	68	168	1.647	1.647	NUM
biomedich-816	68	169	rs2647044	rs2647044	NOUN
biomedich-816	68	170	0.01853	0.01853	NUM
biomedich-816	68	171	1.516	1.516	NUM
biomedich-816	68	172	rs2814828	rs2814828	PROPN
biomedich-816	68	173	0.04725	0.04725	NUM
biomedich-816	68	174	1.415	1.415	NUM
biomedich-816	68	175	rs655601	rs655601	NOUN
biomedich-816	68	176	0.02947	0.02947	NUM
biomedich-816	68	177	1.643	1.643	NUM
biomedich-816	68	178	rs6570507	rs6570507	NOUN
biomedich-816	68	179	0.01169	0.01169	NUM
biomedich-816	68	180	1.514	1.514	NUM
biomedich-816	68	181	rs164898	rs164898	NOUN
biomedich-816	68	182	0.03647	0.03647	NUM
biomedich-816	68	183	1.413	1.413	NUM
biomedich-816	68	184	rs6062314	rs6062314	NOUN
biomedich-816	68	185	0.04578	0.04578	NUM
biomedich-816	68	186	1.641	1.641	NUM
biomedich-816	68	187	rs2358944	rs2358944	PROPN
biomedich-816	68	188	0.04436	0.04436	NUM
biomedich-816	68	189	1.508	1.508	NUM
biomedich-816	68	190	rs3923809	rs3923809	NOUN
biomedich-816	68	191	0.0354	0.0354	NUM
biomedich-816	68	192	1.407	1.407	NUM
biomedich-816	68	193	rs10506458	rs10506458	NOUN
biomedich-816	68	194	0.02917	0.02917	NUM
biomedich-816	68	195	1.632	1.632	NUM
biomedich-816	68	196	rs7871764	rs7871764	NOUN
biomedich-816	68	197	0.0161	0.0161	NUM
biomedich-816	68	198	1.485	1.485	NUM
biomedich-816	68	199	rs470490	rs470490	PROPN
biomedich-816	68	200	0.03335	0.03335	NUM
biomedich-816	68	201	1.402	1.402	NUM
biomedich-816	68	202	rs1317209	rs1317209	NOUN
biomedich-816	68	203	0.008025	0.008025	NUM
biomedich-816	68	204	1.627	1.627	NUM
biomedich-816	68	205	rs935334	rs935334	NOUN
biomedich-816	68	206	0.03898	0.03898	NUM
biomedich-816	68	207	1.483	1.483	NUM
biomedich-816	68	208	rs5751901	rs5751901	NOUN
biomedich-816	68	209	0.03682	0.03682	NUM
biomedich-816	68	210	1.4	1.4	NUM
biomedich-816	68	211	rs8043440	rs8043440	NOUN
biomedich-816	68	212	0.0232	0.0232	NUM
biomedich-816	68	213	1.621	1.621	NUM
biomedich-816	68	214	rs3748069	rs3748069	NOUN
biomedich-816	68	215	0.01702	0.01702	NUM
biomedich-816	68	216	1.482	1.482	NUM
biomedich-816	68	217	rs8083346	rs8083346	VERB
biomedich-816	68	218	0.04033	0.04033	NUM
biomedich-816	68	219	1.4	1.4	NUM
biomedich-816	68	220	rs9357155	rs9357155	PROPN
biomedich-816	68	221	0.02425	0.02425	NUM
biomedich-816	68	222	1.619	1.619	NUM
biomedich-816	68	223	rs378108	rs378108	NOUN
biomedich-816	68	224	0.01635	0.01635	NUM
biomedich-816	68	225	1.477	1.477	NUM
biomedich-816	68	226	rs2275215	rs2275215	VERB
biomedich-816	68	227	0.0479	0.0479	NUM
biomedich-816	68	228	1.397	1.397	NUM
biomedich-816	68	229	rs2681472	rs2681472	NOUN
biomedich-816	68	230	0.01006	0.01006	NUM
biomedich-816	68	231	1.617	1.617	NUM
biomedich-816	68	232	rs1464500	rs1464500	NOUN
biomedich-816	68	233	0.01959	0.01959	NUM
biomedich-816	68	234	1.475	1.475	NUM
biomedich-816	68	235	rs610604	rs610604	NOUN
biomedich-816	68	236	0.04577	0.04577	NUM
biomedich-816	68	237	1.387	1.387	NUM
biomedich-816	68	238	rs2681492	rs2681492	ADP
biomedich-816	68	239	0.01059	0.01059	NUM
biomedich-816	68	240	1.612	1.612	NUM
biomedich-816	68	241	rs6478109	rs6478109	VERB
biomedich-816	68	242	0.01484	0.01484	NUM
biomedich-816	68	243	1.474	1.474	NUM
biomedich-816	68	244	rs1364063	rs1364063	NOUN
biomedich-816	68	245	0.04131	0.04131	NUM
biomedich-816	68	246	1.379	1.379	NUM
biomedich-816	68	247	rs1521882	rs1521882	NOUN
biomedich-816	68	248	0.009275	0.009275	NUM
biomedich-816	68	249	1.61	1.61	NUM
biomedich-816	68	250	rs4924935	rs4924935	NOUN
biomedich-816	68	251	0.01962	0.01962	NUM
biomedich-816	68	252	1.462	1.462	NUM
biomedich-816	68	253	rs4505848	rs4505848	NOUN
biomedich-816	68	254	0.04561	0.04561	NUM
biomedich-816	68	255	1.374	1.374	NUM
biomedich-816	68	256	rs17291045	rs17291045	PROPN
biomedich-816	68	257	0.01915	0.01915	NUM
biomedich-816	68	258	1.607	1.607	NUM
biomedich-816	68	259	rs1402837	rs1402837	PROPN
biomedich-816	68	260	0.02708	0.02708	NUM
biomedich-816	68	261	1.462	1.462	NUM
biomedich-816	68	262	rs610932	rs610932	NOUN
biomedich-816	68	263	0.04323	0.04323	NUM
biomedich-816	68	264	1.373	1.373	NUM
biomedich-816	68	265	rs12101261	rs12101261	NOUN
biomedich-816	68	266	0.003302	0.003302	NUM
biomedich-816	68	267	1.602	1.602	NUM
biomedich-816	68	268	rs12212193	rs12212193	NOUN
biomedich-816	68	269	0.01818	0.01818	NUM
biomedich-816	68	270	1.459	1.459	NUM
biomedich-816	68	271	rs4838605	rs4838605	NOUN
biomedich-816	68	272	0.04946	0.04946	NUM
biomedich-816	68	273	1.368	1.368	NUM
biomedich-816	68	274	rs10513789	rs10513789	ADV
biomedich-816	68	275	0.007242	0.007242	NUM
biomedich-816	68	276	1.601	1.601	NUM
biomedich-816	68	277	rs8047014	rs8047014	NOUN
biomedich-816	68	278	0.01916	0.01916	NUM
biomedich-816	68	279	1.458	1.458	NUM
biomedich-816	68	280	subsequently	subsequently	ADV
biomedich-816	68	281	,	,	PUNCT
biomedich-816	68	282	these	these	DET
biomedich-816	68	283	86	86	NUM
biomedich-816	68	284	snps	snps	NOUN
biomedich-816	68	285	were	be	AUX
biomedich-816	68	286	further	far	ADV
biomedich-816	68	287	analyzed	analyze	VERB
biomedich-816	68	288	to	to	PART
biomedich-816	68	289	determine	determine	VERB
biomedich-816	68	290	whether	whether	SCONJ
biomedich-816	68	291	they	they	PRON
biomedich-816	68	292	involved	involve	VERB
biomedich-816	68	293	missense	missense	NOUN
biomedich-816	68	294	mutations	mutation	NOUN
biomedich-816	68	295	,	,	PUNCT
biomedich-816	68	296	which	which	PRON
biomedich-816	68	297	are	be	AUX
biomedich-816	68	298	genetic	genetic	ADJ
biomedich-816	68	299	code	code	NOUN
biomedich-816	68	300	alterations	alteration	NOUN
biomedich-816	68	301	resulting	result	VERB
biomedich-816	68	302	in	in	ADP
biomedich-816	68	303	amino	amino	NOUN
biomedich-816	68	304	acid	acid	NOUN
biomedich-816	68	305	substitutions	substitution	NOUN
biomedich-816	68	306	in	in	ADP
biomedich-816	68	307	the	the	DET
biomedich-816	68	308	encoded	encode	VERB
biomedich-816	68	309	proteins	protein	NOUN
biomedich-816	68	310	.	.	PUNCT
biomedich-816	69	1	this	this	DET
biomedich-816	69	2	analysis	analysis	NOUN
biomedich-816	69	3	was	be	AUX
biomedich-816	69	4	performed	perform	VERB
biomedich-816	69	5	using	use	VERB
biomedich-816	69	6	the	the	DET
biomedich-816	69	7	haploreg	haploreg	NOUN
biomedich-816	69	8	v4.2	v4.2	NOUN
biomedich-816	69	9	database	database	NOUN
biomedich-816	69	10	,	,	PUNCT
biomedich-816	69	11	which	which	PRON
biomedich-816	69	12	provides	provide	VERB
biomedich-816	69	13	in	in	ADP
biomedich-816	69	14	-	-	PUNCT
biomedich-816	69	15	depth	depth	NOUN
biomedich-816	69	16	information	information	NOUN
biomedich-816	69	17	on	on	ADP
biomedich-816	69	18	functional	functional	ADJ
biomedich-816	69	19	annotations	annotation	NOUN
biomedich-816	69	20	and	and	CCONJ
biomedich-816	69	21	the	the	DET
biomedich-816	69	22	impact	impact	NOUN
biomedich-816	69	23	of	of	ADP
biomedich-816	69	24	genetic	genetic	ADJ
biomedich-816	69	25	mutations	mutation	NOUN
biomedich-816	69	26	.	.	PUNCT
biomedich-816	70	1	the	the	DET
biomedich-816	70	2	analysis	analysis	NOUN
biomedich-816	70	3	identified	identify	VERB
biomedich-816	70	4	six	six	NUM
biomedich-816	70	5	missense	missense	NOUN
biomedich-816	70	6	snps	snps	NOUN
biomedich-816	70	7	,	,	PUNCT
biomedich-816	70	8	each	each	PRON
biomedich-816	70	9	associated	associate	VERB
biomedich-816	70	10	with	with	ADP
biomedich-816	70	11	one	one	NUM
biomedich-816	70	12	of	of	ADP
biomedich-816	70	13	the	the	DET
biomedich-816	70	14	following	follow	VERB
biomedich-816	70	15	gene	gene	NOUN
biomedich-816	70	16	symbols	symbol	NOUN
biomedich-816	70	17	:	:	PUNCT
biomedich-816	70	18	hnf4a	hnf4a	PROPN
biomedich-816	70	19	,	,	PUNCT
biomedich-816	70	20	tnip1	tnip1	PROPN
biomedich-816	70	21	,	,	PUNCT
biomedich-816	70	22	fam177b	fam177b	PROPN
biomedich-816	70	23	,	,	PUNCT
biomedich-816	70	24	vwa7	vwa7	NOUN
biomedich-816	70	25	,	,	PUNCT
biomedich-816	70	26	vwa7	vwa7	NOUN
biomedich-816	70	27	,	,	PUNCT
biomedich-816	70	28	and	and	CCONJ
biomedich-816	70	29	psmb8	psmb8	NOUN
biomedich-816	70	30	.	.	PUNCT
biomedich-816	71	1	these	these	DET
biomedich-816	71	2	six	six	NUM
biomedich-816	71	3	variants	variant	NOUN
biomedich-816	71	4	are	be	AUX
biomedich-816	71	5	listed	list	VERB
biomedich-816	71	6	in	in	ADP
biomedich-816	71	7	table	table	NOUN
biomedich-816	71	8	2	2	NUM
biomedich-816	71	9	and	and	CCONJ
biomedich-816	71	10	were	be	AUX
biomedich-816	71	11	selected	select	VERB
biomedich-816	71	12	for	for	ADP
biomedich-816	71	13	further	further	ADJ
biomedich-816	71	14	analysis	analysis	NOUN
biomedich-816	71	15	.	.	PUNCT
biomedich-816	72	1	table	table	NOUN
biomedich-816	72	2	2	2	NUM
biomedich-816	72	3	.	.	PUNCT
biomedich-816	73	1	variants	variant	NOUN
biomedich-816	73	2	alleles	allele	NOUN
biomedich-816	73	3	of	of	ADP
biomedich-816	73	4	the	the	DET
biomedich-816	73	5	prioritized	prioritized	ADJ
biomedich-816	73	6	snps	snps	PROPN
biomedich-816	73	7	.	.	PUNCT
biomedich-816	74	1	risk	risk	NOUN
biomedich-816	74	2	variants	variant	NOUN
biomedich-816	74	3	of	of	ADP
biomedich-816	74	4	alleles	allele	NOUN
biomedich-816	74	5	risk	risk	NOUN
biomedich-816	74	6	variants	variant	NOUN
biomedich-816	74	7	of	of	ADP
biomedich-816	74	8	alleles	allele	NOUN
biomedich-816	74	9	in	in	ADP
biomedich-816	74	10	close	close	ADJ
biomedich-816	74	11	proximity	proximity	NOUN
biomedich-816	74	12	with	with	ADP
biomedich-816	74	13	r2	r2	PROPN
biomedich-816	74	14	>	>	PUNCT
biomedich-816	74	15	=	=	SYM
biomedich-816	74	16	0.8	0.8	NUM
biomedich-816	74	17	gencode	gencode	NOUN
biomedich-816	74	18	allele	allele	NOUN
biomedich-816	74	19	location	location	NOUN
biomedich-816	75	1	rs1800961	rs1800961	PROPN
biomedich-816	75	2	hnf4a	hnf4a	PROPN
biomedich-816	75	3	missense	missense	NOUN
biomedich-816	75	4	rs2233287	rs2233287	NOUN
biomedich-816	75	5	rs2233290	rs2233290	PROPN
biomedich-816	75	6	tnip1	tnip1	ADJ
biomedich-816	75	7	missense	missense	NOUN
biomedich-816	75	8	rs6683071	rs6683071	PROPN
biomedich-816	75	9	fam177b	fam177b	X
biomedich-816	76	1	missense	missense	NOUN
biomedich-816	76	2	rs3131379	rs3131379	PROPN
biomedich-816	76	3	rs3101017	rs3101017	PROPN
biomedich-816	76	4	vwa7	vwa7	VERB
biomedich-816	76	5	missense	missense	NOUN
biomedich-816	76	6	rs3117582	rs3117582	NOUN
biomedich-816	76	7	rs3101017	rs3101017	NOUN
biomedich-816	76	8	vwa7	vwa7	VERB
biomedich-816	76	9	missense	missense	NOUN
biomedich-816	76	10	rs9357155	rs9357155	NOUN
biomedich-816	76	11	rs2071543	rs2071543	PROPN
biomedich-816	76	12	psmb8	psmb8	NOUN
biomedich-816	76	13	missense	missense	NOUN
biomedich-816	76	14	to	to	PART
biomedich-816	76	15	evaluate	evaluate	VERB
biomedich-816	76	16	the	the	DET
biomedich-816	76	17	biological	biological	ADJ
biomedich-816	76	18	relevance	relevance	NOUN
biomedich-816	76	19	of	of	ADP
biomedich-816	76	20	these	these	DET
biomedich-816	76	21	genes	gene	NOUN
biomedich-816	76	22	,	,	PUNCT
biomedich-816	76	23	a	a	DET
biomedich-816	76	24	gene	gene	NOUN
biomedich-816	76	25	expression	expression	NOUN
biomedich-816	76	26	analysis	analysis	NOUN
biomedich-816	76	27	across	across	ADP
biomedich-816	76	28	multiple	multiple	ADJ
biomedich-816	76	29	human	human	ADJ
biomedich-816	76	30	tissues	tissue	NOUN
biomedich-816	76	31	was	be	AUX
biomedich-816	76	32	conducted	conduct	VERB
biomedich-816	76	33	using	use	VERB
biomedich-816	76	34	data	datum	NOUN
biomedich-816	76	35	from	from	ADP
biomedich-816	76	36	the	the	DET
biomedich-816	76	37	gtex	gtex	PROPN
biomedich-816	76	38	portal	portal	NOUN
biomedich-816	76	39	,	,	PUNCT
biomedich-816	76	40	with	with	ADP
biomedich-816	76	41	a	a	DET
biomedich-816	76	42	specific	specific	ADJ
biomedich-816	76	43	focus	focus	NOUN
biomedich-816	76	44	on	on	ADP
biomedich-816	76	45	lung	lung	NOUN
biomedich-816	76	46	tissue	tissue	NOUN
biomedich-816	76	47	as	as	ADP
biomedich-816	76	48	the	the	DET
biomedich-816	76	49	primary	primary	ADJ
biomedich-816	76	50	target	target	NOUN
biomedich-816	76	51	of	of	ADP
biomedich-816	76	52	720	720	NUM
biomedich-816	76	53	biology	biology	NOUN
biomedich-816	76	54	,	,	PUNCT
biomedich-816	76	55	medicine	medicine	NOUN
biomedich-816	76	56	,	,	PUNCT
biomedich-816	76	57	&	&	CCONJ
biomedich-816	76	58	natural	natural	ADJ
biomedich-816	76	59	product	product	NOUN
biomedich-816	76	60	chemistry	chemistry	NOUN
biomedich-816	76	61	14	14	NUM
biomedich-816	76	62	(	(	PUNCT
biomedich-816	76	63	2	2	NUM
biomedich-816	76	64	)	)	PUNCT
biomedich-816	76	65	,	,	PUNCT
biomedich-816	76	66	2025	2025	NUM
biomedich-816	76	67	:	:	PUNCT
biomedich-816	76	68	717	717	NUM
biomedich-816	76	69	-	-	SYM
biomedich-816	76	70	723	723	NUM
biomedich-816	76	71	environmental	environmental	ADJ
biomedich-816	76	72	exposure	exposure	NOUN
biomedich-816	76	73	.	.	PUNCT
biomedich-816	77	1	the	the	DET
biomedich-816	77	2	results	result	NOUN
biomedich-816	77	3	revealed	reveal	VERB
biomedich-816	77	4	that	that	SCONJ
biomedich-816	77	5	two	two	NUM
biomedich-816	77	6	genes	gene	NOUN
biomedich-816	77	7	,	,	PUNCT
biomedich-816	77	8	tnip1	tnip1	NOUN
biomedich-816	77	9	and	and	CCONJ
biomedich-816	77	10	psmb8	psmb8	PROPN
biomedich-816	77	11	,	,	PUNCT
biomedich-816	77	12	exhibited	exhibit	VERB
biomedich-816	77	13	high	high	ADJ
biomedich-816	77	14	expression	expression	NOUN
biomedich-816	77	15	levels	level	NOUN
biomedich-816	77	16	in	in	ADP
biomedich-816	77	17	lung	lung	NOUN
biomedich-816	77	18	tissue	tissue	NOUN
biomedich-816	77	19	.	.	PUNCT
biomedich-816	78	1	tnip1	tnip1	PROPN
biomedich-816	78	2	showed	show	VERB
biomedich-816	78	3	a	a	DET
biomedich-816	78	4	high	high	ADJ
biomedich-816	78	5	expression	expression	NOUN
biomedich-816	78	6	with	with	ADP
biomedich-816	78	7	a	a	DET
biomedich-816	78	8	median	median	ADJ
biomedich-816	78	9	transcripts	transcript	NOUN
biomedich-816	78	10	per	per	ADP
biomedich-816	78	11	million	million	NUM
biomedich-816	78	12	(	(	PUNCT
biomedich-816	78	13	tpm	tpm	NOUN
biomedich-816	78	14	)	)	PUNCT
biomedich-816	78	15	value	value	NOUN
biomedich-816	78	16	of	of	ADP
biomedich-816	78	17	113.8	113.8	NUM
biomedich-816	78	18	,	,	PUNCT
biomedich-816	78	19	ranking	rank	VERB
biomedich-816	78	20	fourth	fourth	ADV
biomedich-816	78	21	among	among	ADP
biomedich-816	78	22	all	all	DET
biomedich-816	78	23	analyzed	analyze	VERB
biomedich-816	78	24	tissues	tissue	NOUN
biomedich-816	78	25	figure	figure	NOUN
biomedich-816	78	26	1	1	NUM
biomedich-816	78	27	.	.	PUNCT
biomedich-816	79	1	meanwhile	meanwhile	ADV
biomedich-816	79	2	,	,	PUNCT
biomedich-816	79	3	psmb8	psmb8	NOUN
biomedich-816	79	4	exhibited	exhibit	VERB
biomedich-816	79	5	even	even	ADV
biomedich-816	79	6	higher	high	ADJ
biomedich-816	79	7	expression	expression	NOUN
biomedich-816	79	8	in	in	ADP
biomedich-816	79	9	the	the	DET
biomedich-816	79	10	lungs	lung	NOUN
biomedich-816	79	11	,	,	PUNCT
biomedich-816	79	12	with	with	ADP
biomedich-816	79	13	a	a	DET
biomedich-816	79	14	median	median	ADJ
biomedich-816	79	15	tpm	tpm	PROPN
biomedich-816	79	16	of	of	ADP
biomedich-816	79	17	172.5	172.5	NUM
biomedich-816	79	18	,	,	PUNCT
biomedich-816	79	19	also	also	ADV
biomedich-816	79	20	ranking	rank	VERB
biomedich-816	79	21	as	as	SCONJ
biomedich-816	79	22	the	the	DET
biomedich-816	79	23	fourth	fourth	ADJ
biomedich-816	79	24	highest	high	ADJ
biomedich-816	79	25	among	among	ADP
biomedich-816	79	26	lung	lung	NOUN
biomedich-816	79	27	-	-	PUNCT
biomedich-816	79	28	expressed	express	VERB
biomedich-816	79	29	genes	gene	NOUN
biomedich-816	79	30	figure	figure	VERB
biomedich-816	79	31	2	2	NUM
biomedich-816	79	32	.	.	PUNCT
biomedich-816	80	1	these	these	DET
biomedich-816	80	2	findings	finding	NOUN
biomedich-816	80	3	reinforce	reinforce	VERB
biomedich-816	80	4	the	the	DET
biomedich-816	80	5	hypothesis	hypothesis	NOUN
biomedich-816	80	6	that	that	PRON
biomedich-816	80	7	both	both	DET
biomedich-816	80	8	genes	gene	NOUN
biomedich-816	80	9	play	play	VERB
biomedich-816	80	10	a	a	DET
biomedich-816	80	11	significant	significant	ADJ
biomedich-816	80	12	role	role	NOUN
biomedich-816	80	13	in	in	ADP
biomedich-816	80	14	the	the	DET
biomedich-816	80	15	pathological	pathological	ADJ
biomedich-816	80	16	processes	process	NOUN
biomedich-816	80	17	within	within	ADP
biomedich-816	80	18	the	the	DET
biomedich-816	80	19	lungs	lung	NOUN
biomedich-816	80	20	resulting	result	VERB
biomedich-816	80	21	from	from	ADP
biomedich-816	80	22	environmental	environmental	ADJ
biomedich-816	80	23	exposures	exposure	NOUN
biomedich-816	80	24	.	.	PUNCT
biomedich-816	81	1	figure	figure	NOUN
biomedich-816	81	2	1	1	NUM
biomedich-816	81	3	.	.	PUNCT
biomedich-816	82	1	tnip1	tnip1	ADJ
biomedich-816	82	2	gene	gene	NOUN
biomedich-816	82	3	expression	expression	NOUN
biomedich-816	82	4	based	base	VERB
biomedich-816	82	5	on	on	ADP
biomedich-816	82	6	gtex	gtex	PROPN
biomedich-816	82	7	portal	portal	ADJ
biomedich-816	82	8	analysis	analysis	NOUN
biomedich-816	82	9	.	.	PUNCT
biomedich-816	83	1	figure	figure	NOUN
biomedich-816	83	2	2	2	NUM
biomedich-816	83	3	.	.	PUNCT
biomedich-816	83	4	psmb8	psmb8	NOUN
biomedich-816	83	5	gene	gene	NOUN
biomedich-816	83	6	expression	expression	NOUN
biomedich-816	83	7	based	base	VERB
biomedich-816	83	8	on	on	ADP
biomedich-816	83	9	gtex	gtex	PROPN
biomedich-816	83	10	portal	portal	ADJ
biomedich-816	83	11	analysis	analysis	NOUN
biomedich-816	83	12	.	.	PUNCT
biomedich-816	84	1	the	the	DET
biomedich-816	84	2	next	next	ADJ
biomedich-816	84	3	analysis	analysis	NOUN
biomedich-816	84	4	focused	focus	VERB
biomedich-816	84	5	on	on	ADP
biomedich-816	84	6	identifying	identify	VERB
biomedich-816	84	7	relevant	relevant	ADJ
biomedich-816	84	8	expression	expression	NOUN
biomedich-816	84	9	quantitative	quantitative	ADJ
biomedich-816	84	10	trait	trait	NOUN
biomedich-816	84	11	loci	loci	NOUN
biomedich-816	84	12	(	(	PUNCT
biomedich-816	84	13	eqtls	eqtls	PROPN
biomedich-816	84	14	)	)	PUNCT
biomedich-816	84	15	snps	snps	NOUN
biomedich-816	84	16	that	that	PRON
biomedich-816	84	17	influence	influence	NOUN
biomedich-816	84	18	gene	gene	NOUN
biomedich-816	84	19	expression	expression	NOUN
biomedich-816	84	20	levels	level	NOUN
biomedich-816	84	21	in	in	ADP
biomedich-816	84	22	lung	lung	NOUN
biomedich-816	84	23	tissue	tissue	NOUN
biomedich-816	84	24	.	.	PUNCT
biomedich-816	85	1	based	base	VERB
biomedich-816	85	2	on	on	ADP
biomedich-816	85	3	gtex	gtex	PROPN
biomedich-816	85	4	data	data	PROPN
biomedich-816	85	5	,	,	PUNCT
biomedich-816	85	6	one	one	NUM
biomedich-816	85	7	snp	snp	ADJ
biomedich-816	85	8	,	,	PUNCT
biomedich-816	85	9	rs2071543	rs2071543	PROPN
biomedich-816	85	10	,	,	PUNCT
biomedich-816	85	11	was	be	AUX
biomedich-816	85	12	identified	identify	VERB
biomedich-816	85	13	as	as	ADP
biomedich-816	85	14	both	both	PRON
biomedich-816	85	15	previously	previously	ADV
biomedich-816	85	16	selected	select	VERB
biomedich-816	85	17	and	and	CCONJ
biomedich-816	85	18	functionally	functionally	ADV
biomedich-816	85	19	involved	involve	VERB
biomedich-816	85	20	in	in	ADP
biomedich-816	85	21	gene	gene	NOUN
biomedich-816	85	22	regulation	regulation	NOUN
biomedich-816	85	23	.	.	PUNCT
biomedich-816	86	1	this	this	DET
biomedich-816	86	2	snp	snp	NOUN
biomedich-816	86	3	is	be	AUX
biomedich-816	86	4	associated	associate	VERB
biomedich-816	86	5	with	with	ADP
biomedich-816	86	6	the	the	DET
biomedich-816	86	7	gene	gene	NOUN
biomedich-816	86	8	psmb8	psmb8	NOUN
biomedich-816	86	9	.	.	PUNCT
biomedich-816	87	1	information	information	NOUN
biomedich-816	87	2	regarding	regard	VERB
biomedich-816	87	3	the	the	DET
biomedich-816	87	4	major	major	ADJ
biomedich-816	87	5	and	and	CCONJ
biomedich-816	87	6	minor	minor	ADJ
biomedich-816	87	7	alleles	allele	NOUN
biomedich-816	87	8	of	of	ADP
biomedich-816	87	9	rs2071543	rs2071543	PROPN
biomedich-816	87	10	is	be	AUX
biomedich-816	87	11	presented	present	VERB
biomedich-816	87	12	in	in	ADP
biomedich-816	87	13	table	table	NOUN
biomedich-816	87	14	3	3	NUM
biomedich-816	87	15	.	.	PUNCT
biomedich-816	88	1	the	the	DET
biomedich-816	88	2	gg	gg	NOUN
biomedich-816	88	3	genotype	genotype	NOUN
biomedich-816	88	4	of	of	ADP
biomedich-816	88	5	farid	farid	PROPN
biomedich-816	88	6	et	et	PROPN
biomedich-816	88	7	al	al	PROPN
biomedich-816	88	8	.	.	PROPN
biomedich-816	88	9	–	–	PUNCT
biomedich-816	88	10	investigating	investigate	VERB
biomedich-816	88	11	genetic	genetic	ADJ
biomedich-816	88	12	vulnerability	vulnerability	NOUN
biomedich-816	88	13	to	to	ADP
biomedich-816	88	14	environmental	environmental	ADJ
biomedich-816	88	15	exposures	exposure	NOUN
biomedich-816	88	16	…	…	PUNCT
biomedich-816	88	17	721	721	NUM
biomedich-816	88	18	rs2071543	rs2071543	NOUN
biomedich-816	88	19	showed	show	VERB
biomedich-816	88	20	a	a	DET
biomedich-816	88	21	stronger	strong	ADJ
biomedich-816	88	22	correlation	correlation	NOUN
biomedich-816	88	23	with	with	ADP
biomedich-816	88	24	increased	increase	VERB
biomedich-816	88	25	gene	gene	NOUN
biomedich-816	88	26	expression	expression	NOUN
biomedich-816	88	27	in	in	ADP
biomedich-816	88	28	lung	lung	NOUN
biomedich-816	88	29	tissue	tissue	NOUN
biomedich-816	88	30	compared	compare	VERB
biomedich-816	88	31	to	to	ADP
biomedich-816	88	32	the	the	DET
biomedich-816	88	33	tt	tt	PROPN
biomedich-816	88	34	genotype	genotype	NOUN
biomedich-816	88	35	,	,	PUNCT
biomedich-816	88	36	with	with	ADP
biomedich-816	88	37	a	a	DET
biomedich-816	88	38	correlation	correlation	NOUN
biomedich-816	88	39	coefficient	coefficient	NOUN
biomedich-816	88	40	of	of	ADP
biomedich-816	88	41	0.81	0.81	NUM
biomedich-816	88	42	,	,	PUNCT
biomedich-816	88	43	indicating	indicate	VERB
biomedich-816	88	44	a	a	DET
biomedich-816	88	45	significant	significant	ADJ
biomedich-816	88	46	regulatory	regulatory	ADJ
biomedich-816	88	47	effect	effect	NOUN
biomedich-816	88	48	on	on	ADP
biomedich-816	88	49	gene	gene	NOUN
biomedich-816	88	50	expression	expression	NOUN
biomedich-816	88	51	within	within	ADP
biomedich-816	88	52	the	the	DET
biomedich-816	88	53	target	target	NOUN
biomedich-816	88	54	organ	organ	NOUN
biomedich-816	88	55	.	.	PUNCT
biomedich-816	89	1	as	as	ADP
biomedich-816	89	2	part	part	NOUN
biomedich-816	89	3	of	of	ADP
biomedich-816	89	4	the	the	DET
biomedich-816	89	5	population	population	NOUN
biomedich-816	89	6	-	-	PUNCT
biomedich-816	89	7	level	level	NOUN
biomedich-816	89	8	analysis	analysis	NOUN
biomedich-816	89	9	,	,	PUNCT
biomedich-816	89	10	the	the	DET
biomedich-816	89	11	allelic	allelic	ADJ
biomedich-816	89	12	distribution	distribution	NOUN
biomedich-816	89	13	of	of	ADP
biomedich-816	89	14	rs2071543	rs2071543	PROPN
biomedich-816	89	15	was	be	AUX
biomedich-816	89	16	examined	examine	VERB
biomedich-816	89	17	across	across	ADP
biomedich-816	89	18	different	different	ADJ
biomedich-816	89	19	global	global	ADJ
biomedich-816	89	20	ethnic	ethnic	ADJ
biomedich-816	89	21	groups	group	NOUN
biomedich-816	89	22	using	use	VERB
biomedich-816	89	23	data	datum	NOUN
biomedich-816	89	24	from	from	ADP
biomedich-816	89	25	the	the	DET
biomedich-816	89	26	ensembl	ensembl	NOUN
biomedich-816	89	27	genome	genome	NOUN
biomedich-816	89	28	browser	browser	NOUN
biomedich-816	89	29	.	.	PUNCT
biomedich-816	90	1	the	the	DET
biomedich-816	90	2	results	result	NOUN
biomedich-816	90	3	revealed	reveal	VERB
biomedich-816	90	4	notable	notable	ADJ
biomedich-816	90	5	variation	variation	NOUN
biomedich-816	90	6	in	in	ADP
biomedich-816	90	7	allele	allele	NOUN
biomedich-816	90	8	frequencies	frequency	NOUN
biomedich-816	90	9	among	among	ADP
biomedich-816	90	10	populations	population	NOUN
biomedich-816	90	11	.	.	PUNCT
biomedich-816	91	1	the	the	DET
biomedich-816	91	2	g	g	PROPN
biomedich-816	91	3	allele	allele	PROPN
biomedich-816	91	4	showed	show	VERB
biomedich-816	91	5	the	the	DET
biomedich-816	91	6	highest	high	ADJ
biomedich-816	91	7	frequency	frequency	NOUN
biomedich-816	91	8	in	in	ADP
biomedich-816	91	9	african	african	ADJ
biomedich-816	91	10	populations	population	NOUN
biomedich-816	91	11	,	,	PUNCT
biomedich-816	91	12	at	at	ADP
biomedich-816	91	13	0.904	0.904	NUM
biomedich-816	91	14	(	(	PUNCT
biomedich-816	91	15	1,195	1,195	NUM
biomedich-816	91	16	)	)	PUNCT
biomedich-816	91	17	,	,	PUNCT
biomedich-816	91	18	followed	follow	VERB
biomedich-816	91	19	by	by	ADP
biomedich-816	91	20	south	south	ADJ
biomedich-816	91	21	asian	asian	ADJ
biomedich-816	91	22	and	and	CCONJ
biomedich-816	91	23	european	european	ADJ
biomedich-816	91	24	populations	population	NOUN
biomedich-816	91	25	.	.	PUNCT
biomedich-816	92	1	in	in	ADP
biomedich-816	92	2	contrast	contrast	NOUN
biomedich-816	92	3	,	,	PUNCT
biomedich-816	92	4	the	the	DET
biomedich-816	92	5	lowest	low	ADJ
biomedich-816	92	6	frequency	frequency	NOUN
biomedich-816	92	7	of	of	ADP
biomedich-816	92	8	the	the	DET
biomedich-816	92	9	g	g	PROPN
biomedich-816	92	10	allele	allele	NOUN
biomedich-816	92	11	was	be	AUX
biomedich-816	92	12	observed	observe	VERB
biomedich-816	92	13	in	in	ADP
biomedich-816	92	14	american	american	ADJ
biomedich-816	92	15	populations	population	NOUN
biomedich-816	92	16	,	,	PUNCT
biomedich-816	92	17	at	at	ADP
biomedich-816	92	18	0.663	0.663	NUM
biomedich-816	92	19	(	(	PUNCT
biomedich-816	92	20	230	230	NUM
biomedich-816	92	21	)	)	PUNCT
biomedich-816	92	22	.	.	PUNCT
biomedich-816	93	1	for	for	ADP
biomedich-816	93	2	the	the	DET
biomedich-816	93	3	t	t	PROPN
biomedich-816	93	4	allele	allele	PROPN
biomedich-816	93	5	,	,	PUNCT
biomedich-816	93	6	the	the	DET
biomedich-816	93	7	highest	high	ADJ
biomedich-816	93	8	distribution	distribution	NOUN
biomedich-816	93	9	was	be	AUX
biomedich-816	93	10	also	also	ADV
biomedich-816	93	11	found	find	VERB
biomedich-816	93	12	in	in	ADP
biomedich-816	93	13	african	african	ADJ
biomedich-816	93	14	populations	population	NOUN
biomedich-816	93	15	,	,	PUNCT
biomedich-816	93	16	while	while	SCONJ
biomedich-816	93	17	european	european	ADJ
biomedich-816	93	18	populations	population	NOUN
biomedich-816	93	19	exhibited	exhibit	VERB
biomedich-816	93	20	the	the	DET
biomedich-816	93	21	lowest	low	ADJ
biomedich-816	93	22	frequency	frequency	NOUN
biomedich-816	93	23	of	of	ADP
biomedich-816	93	24	this	this	DET
biomedich-816	93	25	allele	allele	NOUN
biomedich-816	93	26	.	.	PUNCT
biomedich-816	94	1	table	table	NOUN
biomedich-816	94	2	3	3	NUM
biomedich-816	94	3	.	.	PUNCT
biomedich-816	94	4	allele	allele	NOUN
biomedich-816	94	5	frequencies	frequency	NOUN
biomedich-816	94	6	for	for	ADP
biomedich-816	94	7	psmb8	psmb8	NOUN
biomedich-816	94	8	.	.	PUNCT
biomedich-816	95	1	snp	snp	PROPN
biomedich-816	95	2	i	i	PROPN
biomedich-816	95	3	d	d	PROPN
biomedich-816	95	4	position	position	NOUN
biomedich-816	95	5	gene	gene	NOUN
biomedich-816	95	6	symbol	symbol	NOUN
biomedich-816	95	7	location	location	NOUN
biomedich-816	95	8	allele	allele	NOUN
biomedich-816	95	9	allele	allele	PROPN
biomedich-816	95	10	frequency	frequency	PROPN
biomedich-816	95	11	ref	ref	NOUN
biomedich-816	95	12	aff	aff	PROPN
biomedich-816	95	13	afr	afr	PROPN
biomedich-816	95	14	amr	amr	PROPN
biomedich-816	95	15	eur	eur	PROPN
biomedich-816	95	16	sas	sas	PROPN
biomedich-816	95	17	rs2071543	rs2071543	PROPN
biomedich-816	95	18	chr6:32843852	chr6:32843852	PROPN
biomedich-816	95	19	psmb8	psmb8	NOUN
biomedich-816	95	20	missense	missense	NOUN
biomedich-816	95	21	g	g	PROPN
biomedich-816	95	22	t	t	PROPN
biomedich-816	95	23	g	g	NOUN
biomedich-816	95	24	:	:	PUNCT
biomedich-816	95	25	0.904	0.904	NUM
biomedich-816	95	26	(	(	PUNCT
biomedich-816	95	27	1195	1195	NUM
biomedich-816	95	28	)	)	PUNCT
biomedich-816	95	29	t	t	PROPN
biomedich-816	95	30	:	:	PUNCT
biomedich-816	95	31	0.096	0.096	NUM
biomedich-816	95	32	(	(	PUNCT
biomedich-816	95	33	127	127	NUM
biomedich-816	95	34	)	)	PUNCT
biomedich-816	95	35	g	g	NOUN
biomedich-816	95	36	:	:	PUNCT
biomedich-816	95	37	0.663	0.663	NUM
biomedich-816	95	38	(	(	PUNCT
biomedich-816	95	39	230	230	NUM
biomedich-816	95	40	)	)	PUNCT
biomedich-816	95	41	t	t	NOUN
biomedich-816	95	42	:	:	PUNCT
biomedich-816	95	43	0.040	0.040	NUM
biomedich-816	95	44	(	(	PUNCT
biomedich-816	95	45	14	14	NUM
biomedich-816	95	46	)	)	PUNCT
biomedich-816	95	47	g	g	NOUN
biomedich-816	95	48	:	:	PUNCT
biomedich-816	95	49	0.730	0.730	NUM
biomedich-816	95	50	(	(	PUNCT
biomedich-816	95	51	367	367	NUM
biomedich-816	95	52	)	)	PUNCT
biomedich-816	95	53	t	t	PROPN
biomedich-816	95	54	:	:	PUNCT
biomedich-816	95	55	0.024	0.024	NUM
biomedich-816	95	56	(	(	PUNCT
biomedich-816	95	57	12	12	NUM
biomedich-816	95	58	)	)	PUNCT
biomedich-816	95	59	g	g	NOUN
biomedich-816	95	60	:	:	PUNCT
biomedich-816	95	61	0.648	0.648	NUM
biomedich-816	95	62	(	(	PUNCT
biomedich-816	95	63	317	317	NUM
biomedich-816	95	64	)	)	PUNCT
biomedich-816	95	65	t	t	PROPN
biomedich-816	95	66	:	:	PUNCT
biomedich-816	95	67	0.029	0.029	NUM
biomedich-816	95	68	(	(	PUNCT
biomedich-816	95	69	14	14	NUM
biomedich-816	95	70	)	)	PUNCT
biomedich-816	95	71	these	these	DET
biomedich-816	95	72	findings	finding	NOUN
biomedich-816	95	73	indicate	indicate	VERB
biomedich-816	95	74	the	the	DET
biomedich-816	95	75	presence	presence	NOUN
biomedich-816	95	76	of	of	ADP
biomedich-816	95	77	significant	significant	ADJ
biomedich-816	95	78	inter	inter	ADJ
biomedich-816	95	79	-	-	ADJ
biomedich-816	95	80	population	population	ADJ
biomedich-816	95	81	genetic	genetic	ADJ
biomedich-816	95	82	variation	variation	NOUN
biomedich-816	95	83	associated	associate	VERB
biomedich-816	95	84	with	with	ADP
biomedich-816	95	85	snp	snp	NOUN
biomedich-816	95	86	rs2071543	rs2071543	PROPN
biomedich-816	95	87	,	,	PUNCT
biomedich-816	95	88	which	which	PRON
biomedich-816	95	89	may	may	AUX
biomedich-816	95	90	contribute	contribute	VERB
biomedich-816	95	91	to	to	ADP
biomedich-816	95	92	differences	difference	NOUN
biomedich-816	95	93	in	in	ADP
biomedich-816	95	94	susceptibility	susceptibility	NOUN
biomedich-816	95	95	to	to	ADP
biomedich-816	95	96	lung	lung	NOUN
biomedich-816	95	97	diseases	disease	NOUN
biomedich-816	95	98	triggered	trigger	VERB
biomedich-816	95	99	by	by	ADP
biomedich-816	95	100	environmental	environmental	ADJ
biomedich-816	95	101	exposures	exposure	NOUN
biomedich-816	95	102	.	.	PUNCT
biomedich-816	96	1	this	this	PRON
biomedich-816	96	2	highlights	highlight	VERB
biomedich-816	96	3	the	the	DET
biomedich-816	96	4	importance	importance	NOUN
biomedich-816	96	5	of	of	ADP
biomedich-816	96	6	incorporating	incorporate	VERB
biomedich-816	96	7	genomic	genomic	NOUN
biomedich-816	96	8	and	and	CCONJ
biomedich-816	96	9	population	population	NOUN
biomedich-816	96	10	-	-	PUNCT
biomedich-816	96	11	based	base	VERB
biomedich-816	96	12	approaches	approach	NOUN
biomedich-816	96	13	in	in	ADP
biomedich-816	96	14	understanding	understand	VERB
biomedich-816	96	15	disease	disease	NOUN
biomedich-816	96	16	risk	risk	NOUN
biomedich-816	96	17	and	and	CCONJ
biomedich-816	96	18	in	in	ADP
biomedich-816	96	19	the	the	DET
biomedich-816	96	20	development	development	NOUN
biomedich-816	96	21	of	of	ADP
biomedich-816	96	22	more	more	ADV
biomedich-816	96	23	personalized	personalized	ADJ
biomedich-816	96	24	and	and	CCONJ
biomedich-816	96	25	precision	precision	NOUN
biomedich-816	96	26	-	-	PUNCT
biomedich-816	96	27	based	base	VERB
biomedich-816	96	28	medical	medical	ADJ
biomedich-816	96	29	strategies	strategy	NOUN
biomedich-816	96	30	.	.	PUNCT
biomedich-816	97	1	discussion	discussion	NOUN
biomedich-816	97	2	this	this	DET
biomedich-816	97	3	study	study	NOUN
biomedich-816	97	4	highlights	highlight	VERB
biomedich-816	97	5	a	a	DET
biomedich-816	97	6	significant	significant	ADJ
biomedich-816	97	7	association	association	NOUN
biomedich-816	97	8	between	between	ADP
biomedich-816	97	9	specific	specific	ADJ
biomedich-816	97	10	genetic	genetic	ADJ
biomedich-816	97	11	variations	variation	NOUN
biomedich-816	97	12	and	and	CCONJ
biomedich-816	97	13	increased	increase	VERB
biomedich-816	97	14	risk	risk	NOUN
biomedich-816	97	15	of	of	ADP
biomedich-816	97	16	lung	lung	NOUN
biomedich-816	97	17	diseases	disease	NOUN
biomedich-816	97	18	triggered	trigger	VERB
biomedich-816	97	19	by	by	ADP
biomedich-816	97	20	exposure	exposure	NOUN
biomedich-816	97	21	to	to	ADP
biomedich-816	97	22	external	external	ADJ
biomedich-816	97	23	agents	agent	NOUN
biomedich-816	97	24	.	.	PUNCT
biomedich-816	98	1	out	out	ADP
biomedich-816	98	2	of	of	ADP
biomedich-816	98	3	151	151	NUM
biomedich-816	98	4	snps	snp	NOUN
biomedich-816	98	5	initially	initially	ADV
biomedich-816	98	6	identified	identify	VERB
biomedich-816	98	7	through	through	ADP
biomedich-816	98	8	the	the	DET
biomedich-816	98	9	phewas	phewas	PROPN
biomedich-816	98	10	database	database	NOUN
biomedich-816	98	11	,	,	PUNCT
biomedich-816	98	12	86	86	NUM
biomedich-816	98	13	met	meet	VERB
biomedich-816	98	14	the	the	DET
biomedich-816	98	15	study	study	NOUN
biomedich-816	98	16	’s	’s	PART
biomedich-816	98	17	criteria	criterion	NOUN
biomedich-816	98	18	,	,	PUNCT
biomedich-816	98	19	indicating	indicate	VERB
biomedich-816	98	20	their	their	PRON
biomedich-816	98	21	potential	potential	ADJ
biomedich-816	98	22	contribution	contribution	NOUN
biomedich-816	98	23	to	to	ADP
biomedich-816	98	24	pulmonary	pulmonary	ADJ
biomedich-816	98	25	disorders	disorder	NOUN
biomedich-816	98	26	.	.	PUNCT
biomedich-816	99	1	further	further	ADJ
biomedich-816	99	2	analysis	analysis	NOUN
biomedich-816	99	3	revealed	reveal	VERB
biomedich-816	99	4	that	that	SCONJ
biomedich-816	99	5	six	six	NUM
biomedich-816	99	6	of	of	ADP
biomedich-816	99	7	these	these	DET
biomedich-816	99	8	variants	variant	NOUN
biomedich-816	99	9	were	be	AUX
biomedich-816	99	10	missense	missense	NOUN
biomedich-816	99	11	mutations	mutation	NOUN
biomedich-816	99	12	,	,	PUNCT
biomedich-816	99	13	which	which	PRON
biomedich-816	99	14	cause	cause	VERB
biomedich-816	99	15	amino	amino	NOUN
biomedich-816	99	16	acid	acid	NOUN
biomedich-816	99	17	substitutions	substitution	NOUN
biomedich-816	99	18	in	in	ADP
biomedich-816	99	19	the	the	DET
biomedich-816	99	20	resulting	result	VERB
biomedich-816	99	21	proteins	protein	NOUN
biomedich-816	99	22	.	.	PUNCT
biomedich-816	100	1	this	this	PRON
biomedich-816	100	2	is	be	AUX
biomedich-816	100	3	particularly	particularly	ADV
biomedich-816	100	4	important	important	ADJ
biomedich-816	100	5	,	,	PUNCT
biomedich-816	100	6	as	as	SCONJ
biomedich-816	100	7	missense	missense	NOUN
biomedich-816	100	8	mutations	mutation	NOUN
biomedich-816	100	9	can	can	AUX
biomedich-816	100	10	alter	alter	VERB
biomedich-816	100	11	protein	protein	NOUN
biomedich-816	100	12	structure	structure	NOUN
biomedich-816	100	13	and	and	CCONJ
biomedich-816	100	14	function	function	NOUN
biomedich-816	100	15	,	,	PUNCT
biomedich-816	100	16	potentially	potentially	ADV
biomedich-816	100	17	disrupting	disrupt	VERB
biomedich-816	100	18	normal	normal	ADJ
biomedich-816	100	19	biological	biological	ADJ
biomedich-816	100	20	processes	process	NOUN
biomedich-816	100	21	in	in	ADP
biomedich-816	100	22	lung	lung	NOUN
biomedich-816	100	23	tissue	tissue	NOUN
biomedich-816	100	24	.	.	PUNCT
biomedich-816	101	1	among	among	ADP
biomedich-816	101	2	these	these	PRON
biomedich-816	101	3	,	,	PUNCT
biomedich-816	101	4	the	the	DET
biomedich-816	101	5	tnip1	tnip1	ADJ
biomedich-816	101	6	and	and	CCONJ
biomedich-816	101	7	psmb8	psmb8	NOUN
biomedich-816	101	8	genes	gene	NOUN
biomedich-816	101	9	demonstrated	demonstrate	VERB
biomedich-816	101	10	notably	notably	ADV
biomedich-816	101	11	high	high	ADJ
biomedich-816	101	12	expression	expression	NOUN
biomedich-816	101	13	levels	level	NOUN
biomedich-816	101	14	in	in	ADP
biomedich-816	101	15	lung	lung	NOUN
biomedich-816	101	16	tissue	tissue	NOUN
biomedich-816	101	17	,	,	PUNCT
biomedich-816	101	18	according	accord	VERB
biomedich-816	101	19	to	to	ADP
biomedich-816	101	20	data	datum	NOUN
biomedich-816	101	21	from	from	ADP
biomedich-816	101	22	the	the	DET
biomedich-816	101	23	gtex	gtex	PROPN
biomedich-816	101	24	portal	portal	PROPN
biomedich-816	101	25	.	.	PUNCT
biomedich-816	102	1	the	the	DET
biomedich-816	102	2	tnip1	tnip1	ADJ
biomedich-816	102	3	gene	gene	NOUN
biomedich-816	102	4	is	be	AUX
biomedich-816	102	5	known	know	VERB
biomedich-816	102	6	to	to	PART
biomedich-816	102	7	be	be	AUX
biomedich-816	102	8	involved	involve	VERB
biomedich-816	102	9	in	in	ADP
biomedich-816	102	10	regulating	regulate	VERB
biomedich-816	102	11	immune	immune	ADJ
biomedich-816	102	12	responses	response	NOUN
biomedich-816	102	13	and	and	CCONJ
biomedich-816	102	14	inflammatory	inflammatory	ADJ
biomedich-816	102	15	processes	process	NOUN
biomedich-816	102	16	via	via	ADP
biomedich-816	102	17	the	the	DET
biomedich-816	102	18	nf	nf	ADJ
biomedich-816	102	19	-	-	PUNCT
biomedich-816	102	20	κb	κb	NOUN
biomedich-816	102	21	pathway	pathway	NOUN
biomedich-816	102	22	,	,	PUNCT
biomedich-816	102	23	which	which	PRON
biomedich-816	102	24	plays	play	VERB
biomedich-816	102	25	a	a	DET
biomedich-816	102	26	central	central	ADJ
biomedich-816	102	27	role	role	NOUN
biomedich-816	102	28	in	in	ADP
biomedich-816	102	29	the	the	DET
biomedich-816	102	30	pathophysiology	pathophysiology	NOUN
biomedich-816	102	31	of	of	ADP
biomedich-816	102	32	inflammatory	inflammatory	ADJ
biomedich-816	102	33	lung	lung	NOUN
biomedich-816	102	34	diseases	disease	NOUN
biomedich-816	102	35	such	such	ADJ
biomedich-816	102	36	as	as	ADP
biomedich-816	102	37	asthma	asthma	NOUN
biomedich-816	102	38	and	and	CCONJ
biomedich-816	102	39	chronic	chronic	ADJ
biomedich-816	102	40	obstructive	obstructive	ADJ
biomedich-816	102	41	pulmonary	pulmonary	ADJ
biomedich-816	102	42	disease	disease	NOUN
biomedich-816	102	43	(	(	PUNCT
biomedich-816	102	44	shamilov	shamilov	NOUN
biomedich-816	102	45	&	&	CCONJ
biomedich-816	102	46	aneskievich	aneskievich	PROPN
biomedich-816	102	47	,	,	PUNCT
biomedich-816	102	48	2018	2018	NUM
biomedich-816	102	49	)	)	PUNCT
biomedich-816	102	50	.	.	PUNCT
biomedich-816	103	1	in	in	ADP
biomedich-816	103	2	contrast	contrast	NOUN
biomedich-816	103	3	,	,	PUNCT
biomedich-816	103	4	the	the	DET
biomedich-816	103	5	psmb8	psmb8	NOUN
biomedich-816	103	6	gene	gene	NOUN
biomedich-816	103	7	encodes	encode	VERB
biomedich-816	103	8	a	a	DET
biomedich-816	103	9	subunit	subunit	NOUN
biomedich-816	103	10	of	of	ADP
biomedich-816	103	11	the	the	DET
biomedich-816	103	12	immunoproteasome	immunoproteasome	NOUN
biomedich-816	103	13	,	,	PUNCT
biomedich-816	103	14	which	which	PRON
biomedich-816	103	15	is	be	AUX
biomedich-816	103	16	essential	essential	ADJ
biomedich-816	103	17	for	for	ADP
biomedich-816	103	18	antigen	antigen	NOUN
biomedich-816	103	19	processing	processing	NOUN
biomedich-816	103	20	and	and	CCONJ
biomedich-816	103	21	the	the	DET
biomedich-816	103	22	regulation	regulation	NOUN
biomedich-816	103	23	of	of	ADP
biomedich-816	103	24	adaptive	adaptive	ADJ
biomedich-816	103	25	immune	immune	ADJ
biomedich-816	103	26	responses	response	NOUN
biomedich-816	103	27	.	.	PUNCT
biomedich-816	104	1	the	the	DET
biomedich-816	104	2	high	high	ADJ
biomedich-816	104	3	expression	expression	NOUN
biomedich-816	104	4	of	of	ADP
biomedich-816	104	5	both	both	DET
biomedich-816	104	6	genes	gene	NOUN
biomedich-816	104	7	in	in	ADP
biomedich-816	104	8	lung	lung	NOUN
biomedich-816	104	9	tissue	tissue	NOUN
biomedich-816	104	10	supports	support	VERB
biomedich-816	104	11	the	the	DET
biomedich-816	104	12	hypothesis	hypothesis	NOUN
biomedich-816	104	13	that	that	PRON
biomedich-816	104	14	genetic	genetic	ADJ
biomedich-816	104	15	variations	variation	NOUN
biomedich-816	104	16	in	in	ADP
biomedich-816	104	17	tnip1	tnip1	NOUN
biomedich-816	104	18	and	and	CCONJ
biomedich-816	104	19	psmb8	psmb8	NOUN
biomedich-816	104	20	may	may	AUX
biomedich-816	104	21	contribute	contribute	VERB
biomedich-816	104	22	to	to	ADP
biomedich-816	104	23	immune	immune	ADJ
biomedich-816	104	24	dysfunction	dysfunction	NOUN
biomedich-816	104	25	and	and	CCONJ
biomedich-816	104	26	chronic	chronic	ADJ
biomedich-816	104	27	inflammation	inflammation	NOUN
biomedich-816	104	28	in	in	ADP
biomedich-816	104	29	response	response	NOUN
biomedich-816	104	30	to	to	ADP
biomedich-816	104	31	toxic	toxic	ADJ
biomedich-816	104	32	exposures	exposure	NOUN
biomedich-816	104	33	such	such	ADJ
biomedich-816	104	34	as	as	ADP
biomedich-816	104	35	air	air	NOUN
biomedich-816	104	36	pollution	pollution	NOUN
biomedich-816	104	37	,	,	PUNCT
biomedich-816	104	38	cigarette	cigarette	NOUN
biomedich-816	104	39	smoke	smoke	NOUN
biomedich-816	104	40	,	,	PUNCT
biomedich-816	104	41	and	and	CCONJ
biomedich-816	104	42	industrial	industrial	ADJ
biomedich-816	104	43	particles	particle	NOUN
biomedich-816	104	44	.	.	PUNCT
biomedich-816	105	1	the	the	DET
biomedich-816	105	2	psmb8	psmb8	NOUN
biomedich-816	105	3	,	,	PUNCT
biomedich-816	105	4	which	which	PRON
biomedich-816	105	5	encodes	encode	VERB
biomedich-816	105	6	the	the	DET
biomedich-816	105	7	β	β	X
biomedich-816	105	8	subunit	subunit	NOUN
biomedich-816	105	9	of	of	ADP
biomedich-816	105	10	the	the	DET
biomedich-816	105	11	immunoproteasome	immunoproteasome	NOUN
biomedich-816	105	12	,	,	PUNCT
biomedich-816	105	13	plays	play	VERB
biomedich-816	105	14	a	a	DET
biomedich-816	105	15	critical	critical	ADJ
biomedich-816	105	16	role	role	NOUN
biomedich-816	105	17	in	in	ADP
biomedich-816	105	18	maintaining	maintain	VERB
biomedich-816	105	19	immune	immune	ADJ
biomedich-816	105	20	homeostasis	homeostasis	NOUN
biomedich-816	105	21	,	,	PUNCT
biomedich-816	105	22	particularly	particularly	ADV
biomedich-816	105	23	in	in	ADP
biomedich-816	105	24	lung	lung	NOUN
biomedich-816	105	25	diseases	disease	NOUN
biomedich-816	105	26	induced	induce	VERB
biomedich-816	105	27	by	by	ADP
biomedich-816	105	28	environmental	environmental	ADJ
biomedich-816	105	29	exposures	exposure	NOUN
biomedich-816	105	30	.	.	PUNCT
biomedich-816	106	1	previous	previous	ADJ
biomedich-816	106	2	studies	study	NOUN
biomedich-816	106	3	have	have	AUX
biomedich-816	106	4	shown	show	VERB
biomedich-816	106	5	that	that	SCONJ
biomedich-816	106	6	psmb8	psmb8	NOUN
biomedich-816	106	7	polymorphisms	polymorphism	NOUN
biomedich-816	106	8	are	be	AUX
biomedich-816	106	9	significantly	significantly	ADV
biomedich-816	106	10	associated	associate	VERB
biomedich-816	106	11	with	with	ADP
biomedich-816	106	12	increased	increase	VERB
biomedich-816	106	13	risk	risk	NOUN
biomedich-816	106	14	of	of	ADP
biomedich-816	106	15	hypersensitivity	hypersensitivity	NOUN
biomedich-816	106	16	pneumonitis	pneumonitis	NOUN
biomedich-816	106	17	(	(	PUNCT
biomedich-816	106	18	hp	hp	PROPN
biomedich-816	106	19	)	)	PUNCT
biomedich-816	106	20	among	among	ADP
biomedich-816	106	21	bird	bird	NOUN
biomedich-816	106	22	breeders	breeder	NOUN
biomedich-816	106	23	(	(	PUNCT
biomedich-816	106	24	camarena	camarena	NOUN
biomedich-816	106	25	et	et	PROPN
biomedich-816	106	26	al	al	PROPN
biomedich-816	106	27	.	.	PROPN
biomedich-816	106	28	,	,	PUNCT
biomedich-816	106	29	2010	2010	NUM
biomedich-816	106	30	)	)	PUNCT
biomedich-816	106	31	.	.	PUNCT
biomedich-816	107	1	for	for	ADP
biomedich-816	107	2	instance	instance	NOUN
biomedich-816	107	3	,	,	PUNCT
biomedich-816	107	4	camarena	camarena	NOUN
biomedich-816	107	5	et	et	PROPN
biomedich-816	107	6	al	al	PROPN
biomedich-816	107	7	.	.	PROPN
biomedich-816	108	1	(	(	PUNCT
biomedich-816	108	2	2010	2010	NUM
biomedich-816	108	3	)	)	PUNCT
biomedich-816	108	4	reported	report	VERB
biomedich-816	108	5	that	that	SCONJ
biomedich-816	108	6	individuals	individual	NOUN
biomedich-816	108	7	carrying	carry	VERB
biomedich-816	108	8	the	the	DET
biomedich-816	108	9	psmb8	psmb8	NOUN
biomedich-816	108	10	kq	kq	PROPN
biomedich-816	108	11	genotype	genotype	NOUN
biomedich-816	108	12	had	have	VERB
biomedich-816	108	13	an	an	DET
biomedich-816	108	14	odds	odd	NOUN
biomedich-816	108	15	ratio	ratio	NOUN
biomedich-816	108	16	of	of	ADP
biomedich-816	108	17	7.25	7.25	NUM
biomedich-816	108	18	for	for	ADP
biomedich-816	108	19	developing	develop	VERB
biomedich-816	108	20	hp	hp	NOUN
biomedich-816	108	21	compared	compare	VERB
biomedich-816	108	22	to	to	ADP
biomedich-816	108	23	healthy	healthy	ADJ
biomedich-816	108	24	controls	control	NOUN
biomedich-816	108	25	(	(	PUNCT
biomedich-816	108	26	p	p	NOUN
biomedich-816	108	27	=	=	NOUN
biomedich-816	108	28	0.000034	0.000034	NUM
biomedich-816	108	29	)	)	PUNCT
biomedich-816	108	30	,	,	PUNCT
biomedich-816	108	31	suggesting	suggest	VERB
biomedich-816	108	32	that	that	SCONJ
biomedich-816	108	33	this	this	DET
biomedich-816	108	34	genetic	genetic	ADJ
biomedich-816	108	35	variant	variant	NOUN
biomedich-816	108	36	may	may	AUX
biomedich-816	108	37	lead	lead	VERB
biomedich-816	108	38	to	to	ADP
biomedich-816	108	39	dysregulation	dysregulation	NOUN
biomedich-816	108	40	of	of	ADP
biomedich-816	108	41	antigen	antigen	NOUN
biomedich-816	108	42	processing	processing	NOUN
biomedich-816	108	43	and	and	CCONJ
biomedich-816	108	44	adaptive	adaptive	ADJ
biomedich-816	108	45	immune	immune	ADJ
biomedich-816	108	46	activation	activation	NOUN
biomedich-816	108	47	via	via	ADP
biomedich-816	108	48	the	the	DET
biomedich-816	108	49	mhc	mhc	PROPN
biomedich-816	108	50	class	class	NOUN
biomedich-816	108	51	i	i	PROPN
biomedich-816	108	52	pathway	pathway	NOUN
biomedich-816	108	53	.	.	PUNCT
biomedich-816	109	1	moreover	moreover	ADV
biomedich-816	109	2	,	,	PUNCT
biomedich-816	109	3	mutations	mutation	NOUN
biomedich-816	109	4	in	in	ADP
biomedich-816	109	5	psmb8	psmb8	NOUN
biomedich-816	109	6	have	have	AUX
biomedich-816	109	7	been	be	AUX
biomedich-816	109	8	implicated	implicate	VERB
biomedich-816	109	9	in	in	ADP
biomedich-816	109	10	candle	candle	NOUN
biomedich-816	109	11	syndrome	syndrome	NOUN
biomedich-816	109	12	,	,	PUNCT
biomedich-816	109	13	a	a	DET
biomedich-816	109	14	rare	rare	ADJ
biomedich-816	109	15	autoinflammatory	autoinflammatory	NOUN
biomedich-816	109	16	disorder	disorder	NOUN
biomedich-816	109	17	characterized	characterize	VERB
biomedich-816	109	18	by	by	ADP
biomedich-816	109	19	interferon	interferon	ADJ
biomedich-816	109	20	dysregulation	dysregulation	NOUN
biomedich-816	109	21	and	and	CCONJ
biomedich-816	109	22	elevated	elevated	ADJ
biomedich-816	109	23	expression	expression	NOUN
biomedich-816	109	24	of	of	ADP
biomedich-816	109	25	inflammatory	inflammatory	ADJ
biomedich-816	109	26	mediators	mediator	NOUN
biomedich-816	109	27	such	such	ADJ
biomedich-816	109	28	as	as	ADP
biomedich-816	109	29	ip-10	ip-10	NOUN
biomedich-816	109	30	,	,	PUNCT
biomedich-816	109	31	il-6	il-6	NOUN
biomedich-816	109	32	,	,	PUNCT
biomedich-816	109	33	and	and	CCONJ
biomedich-816	109	34	mcp-1	mcp-1	NOUN
biomedich-816	109	35	.	.	PUNCT
biomedich-816	110	1	these	these	DET
biomedich-816	110	2	mediators	mediator	NOUN
biomedich-816	110	3	are	be	AUX
biomedich-816	110	4	also	also	ADV
biomedich-816	110	5	involved	involve	VERB
biomedich-816	110	6	in	in	ADP
biomedich-816	110	7	chronic	chronic	ADJ
biomedich-816	110	8	pulmonary	pulmonary	NOUN
biomedich-816	110	9	diseases	disease	NOUN
biomedich-816	110	10	like	like	ADP
biomedich-816	110	11	copd	copd	NOUN
biomedich-816	110	12	and	and	CCONJ
biomedich-816	110	13	fibrosis	fibrosis	NOUN
biomedich-816	110	14	(	(	PUNCT
biomedich-816	110	15	liu	liu	PROPN
biomedich-816	110	16	et	et	PROPN
biomedich-816	110	17	al	al	PROPN
biomedich-816	110	18	.	.	PROPN
biomedich-816	110	19	,	,	PUNCT
biomedich-816	110	20	2012	2012	NUM
biomedich-816	110	21	)	)	PUNCT
biomedich-816	110	22	.	.	PUNCT
biomedich-816	111	1	the	the	DET
biomedich-816	111	2	enhanced	enhance	VERB
biomedich-816	111	3	activation	activation	NOUN
biomedich-816	111	4	of	of	ADP
biomedich-816	111	5	the	the	DET
biomedich-816	111	6	interferon	interferon	ADJ
biomedich-816	111	7	pathway	pathway	NOUN
biomedich-816	111	8	in	in	ADP
biomedich-816	111	9	such	such	ADJ
biomedich-816	111	10	cases	case	NOUN
biomedich-816	111	11	suggests	suggest	VERB
biomedich-816	111	12	that	that	SCONJ
biomedich-816	111	13	psmb8	psmb8	NOUN
biomedich-816	111	14	mutations	mutation	NOUN
biomedich-816	111	15	may	may	AUX
biomedich-816	111	16	induce	induce	VERB
biomedich-816	111	17	damaging	damaging	ADJ
biomedich-816	111	18	immune	immune	ADJ
biomedich-816	111	19	hyperactivity	hyperactivity	NOUN
biomedich-816	111	20	in	in	ADP
biomedich-816	111	21	lung	lung	NOUN
biomedich-816	111	22	tissue	tissue	NOUN
biomedich-816	111	23	over	over	ADP
biomedich-816	111	24	time	time	NOUN
biomedich-816	111	25	.	.	PUNCT
biomedich-816	112	1	additionally	additionally	ADV
biomedich-816	112	2	,	,	PUNCT
biomedich-816	112	3	psmb8	psmb8	NOUN
biomedich-816	112	4	has	have	AUX
biomedich-816	112	5	been	be	AUX
biomedich-816	112	6	linked	link	VERB
biomedich-816	112	7	to	to	ADP
biomedich-816	112	8	cellular	cellular	ADJ
biomedich-816	112	9	transformation	transformation	NOUN
biomedich-816	112	10	mechanisms	mechanism	NOUN
biomedich-816	112	11	following	follow	VERB
biomedich-816	112	12	exposure	exposure	NOUN
biomedich-816	112	13	to	to	ADP
biomedich-816	112	14	environmental	environmental	ADJ
biomedich-816	112	15	carcinogens	carcinogen	NOUN
biomedich-816	112	16	like	like	ADP
biomedich-816	112	17	cigarette	cigarette	NOUN
biomedich-816	112	18	smoke	smoke	NOUN
biomedich-816	112	19	.	.	PUNCT
biomedich-816	113	1	recent	recent	ADJ
biomedich-816	113	2	research	research	NOUN
biomedich-816	113	3	demonstrated	demonstrate	VERB
biomedich-816	113	4	that	that	SCONJ
biomedich-816	113	5	chronic	chronic	ADJ
biomedich-816	113	6	exposure	exposure	NOUN
biomedich-816	113	7	to	to	ADP
biomedich-816	113	8	nnk	nnk	PRON
biomedich-816	113	9	,	,	PUNCT
biomedich-816	113	10	a	a	DET
biomedich-816	113	11	carcinogenic	carcinogenic	ADJ
biomedich-816	113	12	compound	compound	NOUN
biomedich-816	113	13	in	in	ADP
biomedich-816	113	14	tobacco	tobacco	NOUN
biomedich-816	113	15	,	,	PUNCT
biomedich-816	113	16	significantly	significantly	ADV
biomedich-816	113	17	increases	increase	VERB
biomedich-816	113	18	the	the	DET
biomedich-816	113	19	expression	expression	NOUN
biomedich-816	113	20	of	of	ADP
biomedich-816	113	21	the	the	DET
biomedich-816	113	22	long	long	ADJ
biomedich-816	113	23	non	non	ADJ
biomedich-816	113	24	-	-	ADJ
biomedich-816	113	25	coding	coding	ADJ
biomedich-816	113	26	rna	rna	NOUN
biomedich-816	113	27	psmb8	psmb8	NOUN
biomedich-816	113	28	-	-	PUNCT
biomedich-816	113	29	as1	as1	NOUN
biomedich-816	113	30	in	in	ADP
biomedich-816	113	31	human	human	ADJ
biomedich-816	113	32	bronchial	bronchial	ADJ
biomedich-816	113	33	epithelial	epithelial	ADJ
biomedich-816	113	34	cells	cell	NOUN
biomedich-816	113	35	(	(	PUNCT
biomedich-816	113	36	ou	ou	X
biomedich-816	113	37	et	et	PROPN
biomedich-816	113	38	al	al	PROPN
biomedich-816	113	39	.	.	PROPN
biomedich-816	113	40	,	,	PUNCT
biomedich-816	113	41	2024	2024	NUM
biomedich-816	113	42	)	)	PUNCT
biomedich-816	113	43	.	.	PUNCT
biomedich-816	114	1	this	this	DET
biomedich-816	114	2	lncrna	lncrna	NOUN
biomedich-816	114	3	regulates	regulate	VERB
biomedich-816	114	4	the	the	DET
biomedich-816	114	5	cell	cell	NOUN
biomedich-816	114	6	cycle	cycle	NOUN
biomedich-816	114	7	by	by	ADP
biomedich-816	114	8	influencing	influence	VERB
biomedich-816	114	9	cdk1	cdk1	NOUN
biomedich-816	114	10	expression	expression	NOUN
biomedich-816	114	11	.	.	PUNCT
biomedich-816	115	1	its	its	PRON
biomedich-816	115	2	silencing	silencing	NOUN
biomedich-816	115	3	leads	lead	NOUN
biomedich-816	115	4	to	to	ADP
biomedich-816	115	5	g2	g2	PROPN
biomedich-816	115	6	/	/	SYM
biomedich-816	115	7	m	m	PROPN
biomedich-816	115	8	phase	phase	NOUN
biomedich-816	115	9	arrest	arrest	NOUN
biomedich-816	115	10	,	,	PUNCT
biomedich-816	115	11	reduced	reduce	VERB
biomedich-816	115	12	cell	cell	NOUN
biomedich-816	115	13	proliferation	proliferation	NOUN
biomedich-816	115	14	,	,	PUNCT
biomedich-816	115	15	and	and	CCONJ
biomedich-816	115	16	increased	increase	VERB
biomedich-816	115	17	apoptosis	apoptosis	NOUN
biomedich-816	115	18	,	,	PUNCT
biomedich-816	115	19	pointing	point	VERB
biomedich-816	115	20	to	to	ADP
biomedich-816	115	21	a	a	DET
biomedich-816	115	22	potential	potential	ADJ
biomedich-816	115	23	epigenetic	epigenetic	ADJ
biomedich-816	115	24	role	role	NOUN
biomedich-816	115	25	for	for	ADP
biomedich-816	115	26	psmb8	psmb8	NOUN
biomedich-816	115	27	in	in	ADP
biomedich-816	115	28	carcinogenic	carcinogenic	ADJ
biomedich-816	115	29	pathways	pathway	NOUN
biomedich-816	115	30	.	.	PUNCT
biomedich-816	116	1	further	further	ADJ
biomedich-816	116	2	studies	study	NOUN
biomedich-816	116	3	in	in	ADP
biomedich-816	116	4	non	non	ADJ
biomedich-816	116	5	-	-	ADJ
biomedich-816	116	6	small	small	ADJ
biomedich-816	116	7	cell	cell	NOUN
biomedich-816	116	8	lung	lung	NOUN
biomedich-816	116	9	cancer	cancer	NOUN
biomedich-816	116	10	(	(	PUNCT
biomedich-816	116	11	nsclc	nsclc	NOUN
biomedich-816	116	12	)	)	PUNCT
biomedich-816	116	13	have	have	AUX
biomedich-816	116	14	shown	show	VERB
biomedich-816	116	15	that	that	SCONJ
biomedich-816	116	16	immunoproteasome	immunoproteasome	NOUN
biomedich-816	116	17	deficiency	deficiency	NOUN
biomedich-816	116	18	,	,	PUNCT
biomedich-816	116	19	including	include	VERB
biomedich-816	116	20	downregulation	downregulation	NOUN
biomedich-816	116	21	of	of	ADP
biomedich-816	116	22	psmb8	psmb8	NOUN
biomedich-816	116	23	,	,	PUNCT
biomedich-816	116	24	is	be	AUX
biomedich-816	116	25	722	722	NUM
biomedich-816	116	26	biology	biology	NOUN
biomedich-816	116	27	,	,	PUNCT
biomedich-816	116	28	medicine	medicine	NOUN
biomedich-816	116	29	,	,	PUNCT
biomedich-816	116	30	&	&	CCONJ
biomedich-816	116	31	natural	natural	ADJ
biomedich-816	116	32	product	product	NOUN
biomedich-816	116	33	chemistry	chemistry	NOUN
biomedich-816	116	34	14	14	NUM
biomedich-816	116	35	(	(	PUNCT
biomedich-816	116	36	2	2	NUM
biomedich-816	116	37	)	)	PUNCT
biomedich-816	116	38	,	,	PUNCT
biomedich-816	116	39	2025	2025	NUM
biomedich-816	116	40	:	:	PUNCT
biomedich-816	116	41	717	717	NUM
biomedich-816	116	42	-	-	SYM
biomedich-816	116	43	723	723	NUM
biomedich-816	116	44	associated	associate	VERB
biomedich-816	116	45	with	with	ADP
biomedich-816	116	46	a	a	DET
biomedich-816	116	47	mesenchymal	mesenchymal	ADJ
biomedich-816	116	48	phenotype	phenotype	NOUN
biomedich-816	116	49	and	and	CCONJ
biomedich-816	116	50	correlates	correlate	VERB
biomedich-816	116	51	with	with	ADP
biomedich-816	116	52	tumor	tumor	NOUN
biomedich-816	116	53	recurrence	recurrence	NOUN
biomedich-816	116	54	and	and	CCONJ
biomedich-816	116	55	metastasis	metastasis	NOUN
biomedich-816	116	56	(	(	PUNCT
biomedich-816	116	57	tripathi	tripathi	NOUN
biomedich-816	116	58	et	et	PROPN
biomedich-816	116	59	al	al	PROPN
biomedich-816	116	60	.	.	PROPN
biomedich-816	116	61	,	,	PUNCT
biomedich-816	116	62	2016	2016	NUM
biomedich-816	116	63	)	)	PUNCT
biomedich-816	116	64	.	.	PUNCT
biomedich-816	117	1	on	on	ADP
biomedich-816	117	2	the	the	DET
biomedich-816	117	3	other	other	ADJ
biomedich-816	117	4	hand	hand	NOUN
biomedich-816	117	5	,	,	PUNCT
biomedich-816	117	6	high	high	ADJ
biomedich-816	117	7	psmb8	psmb8	NOUN
biomedich-816	117	8	expression	expression	NOUN
biomedich-816	117	9	and	and	CCONJ
biomedich-816	117	10	hypomethylation	hypomethylation	NOUN
biomedich-816	117	11	in	in	ADP
biomedich-816	117	12	lung	lung	NOUN
biomedich-816	117	13	adenocarcinoma	adenocarcinoma	NOUN
biomedich-816	117	14	(	(	PUNCT
biomedich-816	117	15	luad	luad	NOUN
biomedich-816	117	16	)	)	PUNCT
biomedich-816	117	17	tissues	tissue	NOUN
biomedich-816	117	18	are	be	AUX
biomedich-816	117	19	linked	link	VERB
biomedich-816	117	20	to	to	ADP
biomedich-816	117	21	activation	activation	NOUN
biomedich-816	117	22	of	of	ADP
biomedich-816	117	23	anti	anti	ADJ
biomedich-816	117	24	-	-	ADJ
biomedich-816	117	25	tumor	tumor	ADJ
biomedich-816	117	26	immune	immune	ADJ
biomedich-816	117	27	pathways	pathway	NOUN
biomedich-816	117	28	,	,	PUNCT
biomedich-816	117	29	presence	presence	NOUN
biomedich-816	117	30	of	of	ADP
biomedich-816	117	31	effector	effector	NOUN
biomedich-816	117	32	immune	immune	ADJ
biomedich-816	117	33	cells	cell	NOUN
biomedich-816	117	34	,	,	PUNCT
biomedich-816	117	35	and	and	CCONJ
biomedich-816	117	36	improved	improved	ADJ
biomedich-816	117	37	response	response	NOUN
biomedich-816	117	38	to	to	ADP
biomedich-816	117	39	pd-1	pd-1	ADP
biomedich-816	117	40	/	/	SYM
biomedich-816	117	41	pd	pd	ADJ
biomedich-816	117	42	-	-	PUNCT
biomedich-816	117	43	l1	l1	NOUN
biomedich-816	117	44	-	-	PUNCT
biomedich-816	117	45	based	base	VERB
biomedich-816	117	46	immunotherapy	immunotherapy	NOUN
biomedich-816	117	47	(	(	PUNCT
biomedich-816	117	48	xie	xie	PROPN
biomedich-816	117	49	et	et	PROPN
biomedich-816	117	50	al	al	PROPN
biomedich-816	117	51	.	.	PROPN
biomedich-816	117	52	,	,	PUNCT
biomedich-816	117	53	2022	2022	NUM
biomedich-816	117	54	)	)	PUNCT
biomedich-816	117	55	.	.	PUNCT
biomedich-816	118	1	these	these	DET
biomedich-816	118	2	findings	finding	NOUN
biomedich-816	118	3	suggest	suggest	VERB
biomedich-816	118	4	that	that	SCONJ
biomedich-816	118	5	psmb8	psmb8	NOUN
biomedich-816	118	6	through	through	ADP
biomedich-816	118	7	genetic	genetic	ADJ
biomedich-816	118	8	mutation	mutation	NOUN
biomedich-816	118	9	,	,	PUNCT
biomedich-816	118	10	lncrna	lncrna	NOUN
biomedich-816	118	11	expression	expression	NOUN
biomedich-816	118	12	,	,	PUNCT
biomedich-816	118	13	or	or	CCONJ
biomedich-816	118	14	epigenetic	epigenetic	ADJ
biomedich-816	118	15	modification	modification	NOUN
biomedich-816	118	16	holds	hold	VERB
biomedich-816	118	17	potential	potential	NOUN
biomedich-816	118	18	as	as	ADP
biomedich-816	118	19	both	both	CCONJ
biomedich-816	118	20	a	a	DET
biomedich-816	118	21	diagnostic	diagnostic	ADJ
biomedich-816	118	22	biomarker	biomarker	NOUN
biomedich-816	118	23	and	and	CCONJ
biomedich-816	118	24	a	a	DET
biomedich-816	118	25	precision	precision	NOUN
biomedich-816	118	26	therapeutic	therapeutic	ADJ
biomedich-816	118	27	target	target	NOUN
biomedich-816	118	28	in	in	ADP
biomedich-816	118	29	lung	lung	NOUN
biomedich-816	118	30	diseases	disease	NOUN
biomedich-816	118	31	associated	associate	VERB
biomedich-816	118	32	with	with	ADP
biomedich-816	118	33	environmental	environmental	ADJ
biomedich-816	118	34	exposure	exposure	NOUN
biomedich-816	118	35	.	.	PUNCT
biomedich-816	119	1	our	our	PRON
biomedich-816	119	2	analysis	analysis	NOUN
biomedich-816	119	3	also	also	ADV
biomedich-816	119	4	found	find	VERB
biomedich-816	119	5	that	that	SCONJ
biomedich-816	119	6	gene	gene	NOUN
biomedich-816	119	7	variants	variant	NOUN
biomedich-816	119	8	related	relate	VERB
biomedich-816	119	9	to	to	ADP
biomedich-816	119	10	exposure	exposure	NOUN
biomedich-816	119	11	-	-	PUNCT
biomedich-816	119	12	induced	induce	VERB
biomedich-816	119	13	lung	lung	NOUN
biomedich-816	119	14	disease	disease	NOUN
biomedich-816	119	15	showed	show	VERB
biomedich-816	119	16	highest	high	ADJ
biomedich-816	119	17	expression	expression	NOUN
biomedich-816	119	18	levels	level	NOUN
biomedich-816	119	19	in	in	ADP
biomedich-816	119	20	several	several	ADJ
biomedich-816	119	21	tissues	tissue	NOUN
biomedich-816	119	22	,	,	PUNCT
biomedich-816	119	23	including	include	VERB
biomedich-816	119	24	ebvtransformed	ebvtransformed	ADJ
biomedich-816	119	25	lymphocytes	lymphocyte	NOUN
biomedich-816	119	26	,	,	PUNCT
biomedich-816	119	27	blood	blood	NOUN
biomedich-816	119	28	,	,	PUNCT
biomedich-816	119	29	spleen	spleen	NOUN
biomedich-816	119	30	,	,	PUNCT
biomedich-816	119	31	lungs	lung	NOUN
biomedich-816	119	32	,	,	PUNCT
biomedich-816	119	33	and	and	CCONJ
biomedich-816	119	34	adipose	adipose	ADP
biomedich-816	119	35	tissue	tissue	NOUN
biomedich-816	119	36	.	.	PUNCT
biomedich-816	120	1	this	this	DET
biomedich-816	120	2	expression	expression	NOUN
biomedich-816	120	3	pattern	pattern	NOUN
biomedich-816	120	4	aligns	align	VERB
biomedich-816	120	5	with	with	ADP
biomedich-816	120	6	common	common	ADJ
biomedich-816	120	7	clinical	clinical	ADJ
biomedich-816	120	8	manifestations	manifestation	NOUN
biomedich-816	120	9	of	of	ADP
biomedich-816	120	10	pulmonary	pulmonary	ADJ
biomedich-816	120	11	disease	disease	NOUN
biomedich-816	120	12	,	,	PUNCT
biomedich-816	120	13	such	such	ADJ
biomedich-816	120	14	as	as	ADP
biomedich-816	120	15	lymphadenopathy	lymphadenopathy	ADJ
biomedich-816	120	16	,	,	PUNCT
biomedich-816	120	17	pulmonary	pulmonary	ADJ
biomedich-816	120	18	infections	infection	NOUN
biomedich-816	120	19	,	,	PUNCT
biomedich-816	120	20	and	and	CCONJ
biomedich-816	120	21	systemic	systemic	ADJ
biomedich-816	120	22	inflammation	inflammation	NOUN
biomedich-816	120	23	(	(	PUNCT
biomedich-816	120	24	eckhardt	eckhardt	PROPN
biomedich-816	120	25	&	&	CCONJ
biomedich-816	120	26	wu	wu	PROPN
biomedich-816	120	27	,	,	PUNCT
biomedich-816	120	28	2021	2021	NUM
biomedich-816	120	29	)	)	PUNCT
biomedich-816	120	30	.	.	PUNCT
biomedich-816	121	1	the	the	DET
biomedich-816	121	2	discovery	discovery	NOUN
biomedich-816	121	3	of	of	ADP
biomedich-816	121	4	mutagenic	mutagenic	ADJ
biomedich-816	121	5	and	and	CCONJ
biomedich-816	121	6	pathogenic	pathogenic	ADJ
biomedich-816	121	7	genetic	genetic	ADJ
biomedich-816	121	8	variants	variant	NOUN
biomedich-816	121	9	warrants	warrant	NOUN
biomedich-816	121	10	further	further	ADJ
biomedich-816	121	11	laboratory	laboratory	NOUN
biomedich-816	121	12	and	and	CCONJ
biomedich-816	121	13	clinical	clinical	ADJ
biomedich-816	121	14	investigation	investigation	NOUN
biomedich-816	121	15	.	.	PUNCT
biomedich-816	122	1	identifying	identify	VERB
biomedich-816	122	2	such	such	ADJ
biomedich-816	122	3	variants	variant	NOUN
biomedich-816	122	4	not	not	PART
biomedich-816	122	5	only	only	ADV
biomedich-816	122	6	improves	improve	VERB
biomedich-816	122	7	our	our	PRON
biomedich-816	122	8	understanding	understanding	NOUN
biomedich-816	122	9	of	of	ADP
biomedich-816	122	10	disease	disease	NOUN
biomedich-816	122	11	susceptibility	susceptibility	NOUN
biomedich-816	122	12	but	but	CCONJ
biomedich-816	122	13	also	also	ADV
biomedich-816	122	14	supports	support	VERB
biomedich-816	122	15	the	the	DET
biomedich-816	122	16	development	development	NOUN
biomedich-816	122	17	of	of	ADP
biomedich-816	122	18	diagnostic	diagnostic	ADJ
biomedich-816	122	19	or	or	CCONJ
biomedich-816	122	20	prognostic	prognostic	ADJ
biomedich-816	122	21	biomarkers	biomarker	NOUN
biomedich-816	122	22	and	and	CCONJ
biomedich-816	122	23	specific	specific	ADJ
biomedich-816	122	24	therapeutic	therapeutic	ADJ
biomedich-816	122	25	targets	target	NOUN
biomedich-816	122	26	for	for	ADP
biomedich-816	122	27	future	future	ADJ
biomedich-816	122	28	research	research	NOUN
biomedich-816	122	29	(	(	PUNCT
biomedich-816	122	30	adikusuma	adikusuma	ADV
biomedich-816	122	31	et	et	PROPN
biomedich-816	122	32	al	al	PROPN
biomedich-816	122	33	.	.	PROPN
biomedich-816	122	34	,	,	PUNCT
biomedich-816	122	35	2021	2021	NUM
biomedich-816	122	36	;	;	PUNCT
biomedich-816	122	37	qureshi	qureshi	PROPN
biomedich-816	122	38	,	,	PUNCT
biomedich-816	122	39	2020	2020	NUM
biomedich-816	122	40	;	;	PUNCT
biomedich-816	122	41	santri	santri	PROPN
biomedich-816	122	42	et	et	PROPN
biomedich-816	122	43	al	al	PROPN
biomedich-816	122	44	.	.	PROPN
biomedich-816	122	45	,	,	PUNCT
biomedich-816	122	46	2022	2022	NUM
biomedich-816	122	47	)	)	PUNCT
biomedich-816	122	48	.	.	PUNCT
biomedich-816	123	1	these	these	DET
biomedich-816	123	2	findings	finding	NOUN
biomedich-816	123	3	serve	serve	VERB
biomedich-816	123	4	as	as	ADP
biomedich-816	123	5	a	a	DET
biomedich-816	123	6	preliminary	preliminary	ADJ
biomedich-816	123	7	foundation	foundation	NOUN
biomedich-816	123	8	for	for	ADP
biomedich-816	123	9	developing	develop	VERB
biomedich-816	123	10	more	more	ADV
biomedich-816	123	11	effective	effective	ADJ
biomedich-816	123	12	biomarkers	biomarker	NOUN
biomedich-816	123	13	and	and	CCONJ
biomedich-816	123	14	therapeutic	therapeutic	ADJ
biomedich-816	123	15	strategies	strategy	NOUN
biomedich-816	123	16	for	for	ADP
biomedich-816	123	17	environmentally	environmentally	ADV
biomedich-816	123	18	induced	induced	ADJ
biomedich-816	123	19	lung	lung	NOUN
biomedich-816	123	20	disease	disease	NOUN
biomedich-816	123	21	.	.	PUNCT
biomedich-816	124	1	overall	overall	ADV
biomedich-816	124	2	,	,	PUNCT
biomedich-816	124	3	this	this	DET
biomedich-816	124	4	study	study	NOUN
biomedich-816	124	5	underscores	underscore	VERB
biomedich-816	124	6	the	the	DET
biomedich-816	124	7	importance	importance	NOUN
biomedich-816	124	8	of	of	ADP
biomedich-816	124	9	a	a	DET
biomedich-816	124	10	multi	multi	ADJ
biomedich-816	124	11	-	-	ADJ
biomedich-816	124	12	database	database	ADJ
biomedich-816	124	13	approach	approach	NOUN
biomedich-816	124	14	in	in	ADP
biomedich-816	124	15	identifying	identify	VERB
biomedich-816	124	16	genetic	genetic	ADJ
biomedich-816	124	17	biomarkers	biomarker	NOUN
biomedich-816	124	18	relevant	relevant	ADJ
biomedich-816	124	19	to	to	ADP
biomedich-816	124	20	multifactorial	multifactorial	ADJ
biomedich-816	124	21	diseases	disease	NOUN
biomedich-816	124	22	such	such	ADJ
biomedich-816	124	23	as	as	ADP
biomedich-816	124	24	environmentally	environmentally	ADV
biomedich-816	124	25	triggered	trigger	VERB
biomedich-816	124	26	lung	lung	NOUN
biomedich-816	124	27	disorders	disorder	NOUN
biomedich-816	124	28	.	.	PUNCT
biomedich-816	125	1	the	the	DET
biomedich-816	125	2	combination	combination	NOUN
biomedich-816	125	3	of	of	ADP
biomedich-816	125	4	snp	snp	ADJ
biomedich-816	125	5	association	association	PROPN
biomedich-816	125	6	analysis	analysis	NOUN
biomedich-816	125	7	,	,	PUNCT
biomedich-816	125	8	mutation	mutation	NOUN
biomedich-816	125	9	characterization	characterization	NOUN
biomedich-816	125	10	,	,	PUNCT
biomedich-816	125	11	tissue	tissue	NOUN
biomedich-816	125	12	-	-	PUNCT
biomedich-816	125	13	specific	specific	ADJ
biomedich-816	125	14	expression	expression	NOUN
biomedich-816	125	15	profiling	profiling	NOUN
biomedich-816	125	16	,	,	PUNCT
biomedich-816	125	17	and	and	CCONJ
biomedich-816	125	18	population	population	NOUN
biomedich-816	125	19	distribution	distribution	NOUN
biomedich-816	125	20	provides	provide	VERB
biomedich-816	125	21	a	a	DET
biomedich-816	125	22	more	more	ADV
biomedich-816	125	23	comprehensive	comprehensive	ADJ
biomedich-816	125	24	picture	picture	NOUN
biomedich-816	125	25	of	of	ADP
biomedich-816	125	26	the	the	DET
biomedich-816	125	27	molecular	molecular	ADJ
biomedich-816	125	28	mechanisms	mechanism	NOUN
biomedich-816	125	29	underlying	underlie	VERB
biomedich-816	125	30	disease	disease	NOUN
biomedich-816	125	31	susceptibility	susceptibility	NOUN
biomedich-816	125	32	.	.	PUNCT
biomedich-816	126	1	while	while	SCONJ
biomedich-816	126	2	this	this	DET
biomedich-816	126	3	research	research	NOUN
biomedich-816	126	4	is	be	AUX
biomedich-816	126	5	limited	limit	VERB
biomedich-816	126	6	as	as	ADP
biomedich-816	126	7	a	a	DET
biomedich-816	126	8	preliminary	preliminary	ADJ
biomedich-816	126	9	study	study	NOUN
biomedich-816	126	10	based	base	VERB
biomedich-816	126	11	on	on	ADP
biomedich-816	126	12	publicly	publicly	ADV
biomedich-816	126	13	available	available	ADJ
biomedich-816	126	14	genomic	genomic	NOUN
biomedich-816	126	15	and	and	CCONJ
biomedich-816	126	16	bioinformatics	bioinformatics	NOUN
biomedich-816	126	17	databases	database	NOUN
biomedich-816	126	18	,	,	PUNCT
biomedich-816	126	19	it	it	PRON
biomedich-816	126	20	offers	offer	VERB
biomedich-816	126	21	valuable	valuable	ADJ
biomedich-816	126	22	insights	insight	NOUN
biomedich-816	126	23	that	that	PRON
biomedich-816	126	24	can	can	AUX
biomedich-816	126	25	guide	guide	VERB
biomedich-816	126	26	further	further	ADJ
biomedich-816	126	27	investigations	investigation	NOUN
biomedich-816	126	28	.	.	PUNCT
biomedich-816	127	1	future	future	ADJ
biomedich-816	127	2	studies	study	NOUN
biomedich-816	127	3	should	should	AUX
biomedich-816	127	4	aim	aim	VERB
biomedich-816	127	5	to	to	PART
biomedich-816	127	6	validate	validate	VERB
biomedich-816	127	7	these	these	DET
biomedich-816	127	8	findings	finding	NOUN
biomedich-816	127	9	in	in	ADP
biomedich-816	127	10	laboratory	laboratory	NOUN
biomedich-816	127	11	and	and	CCONJ
biomedich-816	127	12	clinical	clinical	ADJ
biomedich-816	127	13	settings	setting	NOUN
biomedich-816	127	14	,	,	PUNCT
biomedich-816	127	15	and	and	CCONJ
biomedich-816	127	16	expand	expand	VERB
biomedich-816	127	17	the	the	DET
biomedich-816	127	18	scope	scope	NOUN
biomedich-816	127	19	to	to	PART
biomedich-816	127	20	discover	discover	VERB
biomedich-816	127	21	additional	additional	ADJ
biomedich-816	127	22	pathogenic	pathogenic	ADJ
biomedich-816	127	23	variants	variant	NOUN
biomedich-816	127	24	.	.	PUNCT
biomedich-816	128	1	thus	thus	ADV
biomedich-816	128	2	,	,	PUNCT
biomedich-816	128	3	this	this	DET
biomedich-816	128	4	research	research	NOUN
biomedich-816	128	5	represents	represent	VERB
biomedich-816	128	6	an	an	DET
biomedich-816	128	7	important	important	ADJ
biomedich-816	128	8	first	first	ADJ
biomedich-816	128	9	step	step	NOUN
biomedich-816	128	10	toward	toward	ADP
biomedich-816	128	11	a	a	DET
biomedich-816	128	12	deeper	deep	ADJ
biomedich-816	128	13	understanding	understanding	NOUN
biomedich-816	128	14	of	of	ADP
biomedich-816	128	15	the	the	DET
biomedich-816	128	16	genetic	genetic	ADJ
biomedich-816	128	17	basis	basis	NOUN
biomedich-816	128	18	of	of	ADP
biomedich-816	128	19	lung	lung	NOUN
biomedich-816	128	20	disease	disease	NOUN
biomedich-816	128	21	and	and	CCONJ
biomedich-816	128	22	the	the	DET
biomedich-816	128	23	development	development	NOUN
biomedich-816	128	24	of	of	ADP
biomedich-816	128	25	more	more	ADV
biomedich-816	128	26	effective	effective	ADJ
biomedich-816	128	27	therapeutic	therapeutic	ADJ
biomedich-816	128	28	approaches	approach	NOUN
biomedich-816	128	29	.	.	PUNCT
biomedich-816	129	1	conclusions	conclusion	NOUN
biomedich-816	129	2	this	this	DET
biomedich-816	129	3	study	study	NOUN
biomedich-816	129	4	demonstrates	demonstrate	VERB
biomedich-816	129	5	the	the	DET
biomedich-816	129	6	potential	potential	ADJ
biomedich-816	129	7	role	role	NOUN
biomedich-816	129	8	of	of	ADP
biomedich-816	129	9	specific	specific	ADJ
biomedich-816	129	10	genetic	genetic	ADJ
biomedich-816	129	11	variants	variant	NOUN
biomedich-816	129	12	,	,	PUNCT
biomedich-816	129	13	particularly	particularly	ADV
biomedich-816	129	14	tnip1	tnip1	ADJ
biomedich-816	129	15	and	and	CCONJ
biomedich-816	129	16	psmb8	psmb8	NOUN
biomedich-816	129	17	,	,	PUNCT
biomedich-816	129	18	in	in	ADP
biomedich-816	129	19	increasing	increase	VERB
biomedich-816	129	20	susceptibility	susceptibility	NOUN
biomedich-816	129	21	to	to	ADP
biomedich-816	129	22	lung	lung	NOUN
biomedich-816	129	23	diseases	disease	NOUN
biomedich-816	129	24	triggered	trigger	VERB
biomedich-816	129	25	by	by	ADP
biomedich-816	129	26	environmental	environmental	ADJ
biomedich-816	129	27	exposures	exposure	NOUN
biomedich-816	129	28	.	.	PUNCT
biomedich-816	130	1	through	through	ADP
biomedich-816	130	2	an	an	DET
biomedich-816	130	3	integrative	integrative	ADJ
biomedich-816	130	4	bioinformatics	bioinformatics	NOUN
biomedich-816	130	5	approach	approach	NOUN
biomedich-816	130	6	,	,	PUNCT
biomedich-816	130	7	six	six	NUM
biomedich-816	130	8	missense	missense	NOUN
biomedich-816	130	9	snps	snps	PROPN
biomedich-816	130	10	were	be	AUX
biomedich-816	130	11	identified	identify	VERB
biomedich-816	130	12	,	,	PUNCT
biomedich-816	130	13	with	with	ADP
biomedich-816	130	14	psmb8	psmb8	NOUN
biomedich-816	130	15	variant	variant	NOUN
biomedich-816	130	16	rs2071543	rs2071543	PROPN
biomedich-816	130	17	showing	show	VERB
biomedich-816	130	18	significant	significant	ADJ
biomedich-816	130	19	expression	expression	NOUN
biomedich-816	130	20	in	in	ADP
biomedich-816	130	21	lung	lung	NOUN
biomedich-816	130	22	tissue	tissue	NOUN
biomedich-816	130	23	and	and	CCONJ
biomedich-816	130	24	variation	variation	NOUN
biomedich-816	130	25	across	across	ADP
biomedich-816	130	26	global	global	ADJ
biomedich-816	130	27	populations	population	NOUN
biomedich-816	130	28	.	.	PUNCT
biomedich-816	131	1	the	the	DET
biomedich-816	131	2	findings	finding	NOUN
biomedich-816	131	3	suggest	suggest	VERB
biomedich-816	131	4	that	that	SCONJ
biomedich-816	131	5	genetic	genetic	ADJ
biomedich-816	131	6	predisposition	predisposition	NOUN
biomedich-816	131	7	,	,	PUNCT
biomedich-816	131	8	combined	combine	VERB
biomedich-816	131	9	with	with	ADP
biomedich-816	131	10	environmental	environmental	ADJ
biomedich-816	131	11	risk	risk	NOUN
biomedich-816	131	12	factors	factor	NOUN
biomedich-816	131	13	,	,	PUNCT
biomedich-816	131	14	may	may	AUX
biomedich-816	131	15	contribute	contribute	VERB
biomedich-816	131	16	to	to	ADP
biomedich-816	131	17	the	the	DET
biomedich-816	131	18	pathogenesis	pathogenesis	NOUN
biomedich-816	131	19	of	of	ADP
biomedich-816	131	20	chronic	chronic	ADJ
biomedich-816	131	21	lung	lung	NOUN
biomedich-816	131	22	conditions	condition	NOUN
biomedich-816	131	23	through	through	ADP
biomedich-816	131	24	immune	immune	ADJ
biomedich-816	131	25	and	and	CCONJ
biomedich-816	131	26	inflammatory	inflammatory	ADJ
biomedich-816	131	27	dysregulation	dysregulation	NOUN
biomedich-816	131	28	.	.	PUNCT
biomedich-816	132	1	these	these	DET
biomedich-816	132	2	results	result	NOUN
biomedich-816	132	3	underscore	underscore	VERB
biomedich-816	132	4	the	the	DET
biomedich-816	132	5	value	value	NOUN
biomedich-816	132	6	of	of	ADP
biomedich-816	132	7	genomic	genomic	NOUN
biomedich-816	132	8	and	and	CCONJ
biomedich-816	132	9	population	population	NOUN
biomedich-816	132	10	-	-	PUNCT
biomedich-816	132	11	based	base	VERB
biomedich-816	132	12	analyses	analysis	NOUN
biomedich-816	132	13	in	in	ADP
biomedich-816	132	14	uncovering	uncover	VERB
biomedich-816	132	15	biomarkers	biomarker	NOUN
biomedich-816	132	16	for	for	ADP
biomedich-816	132	17	early	early	ADJ
biomedich-816	132	18	detection	detection	NOUN
biomedich-816	132	19	and	and	CCONJ
biomedich-816	132	20	precision	precision	NOUN
biomedich-816	132	21	therapy	therapy	NOUN
biomedich-816	132	22	.	.	PUNCT
biomedich-816	133	1	although	although	SCONJ
biomedich-816	133	2	further	further	ADJ
biomedich-816	133	3	experimental	experimental	ADJ
biomedich-816	133	4	validation	validation	NOUN
biomedich-816	133	5	is	be	AUX
biomedich-816	133	6	needed	need	VERB
biomedich-816	133	7	,	,	PUNCT
biomedich-816	133	8	this	this	DET
biomedich-816	133	9	study	study	NOUN
biomedich-816	133	10	provides	provide	VERB
biomedich-816	133	11	a	a	DET
biomedich-816	133	12	foundational	foundational	ADJ
biomedich-816	133	13	step	step	NOUN
biomedich-816	133	14	toward	toward	ADP
biomedich-816	133	15	the	the	DET
biomedich-816	133	16	development	development	NOUN
biomedich-816	133	17	of	of	ADP
biomedich-816	133	18	targeted	target	VERB
biomedich-816	133	19	strategies	strategy	NOUN
biomedich-816	133	20	for	for	ADP
biomedich-816	133	21	the	the	DET
biomedich-816	133	22	prevention	prevention	NOUN
biomedich-816	133	23	and	and	CCONJ
biomedich-816	133	24	treatment	treatment	NOUN
biomedich-816	133	25	of	of	ADP
biomedich-816	133	26	environmentally	environmentally	ADV
biomedich-816	133	27	induced	induced	ADJ
biomedich-816	133	28	lung	lung	NOUN
biomedich-816	133	29	diseases	disease	NOUN
biomedich-816	133	30	.	.	PUNCT
biomedich-816	134	1	acknowledgements	acknowledgement	NOUN
biomedich-816	134	2	:	:	PUNCT
biomedich-816	134	3	we	we	PRON
biomedich-816	134	4	would	would	AUX
biomedich-816	134	5	like	like	VERB
biomedich-816	134	6	to	to	PART
biomedich-816	134	7	express	express	VERB
biomedich-816	134	8	our	our	PRON
biomedich-816	134	9	gratitude	gratitude	NOUN
biomedich-816	134	10	to	to	ADP
biomedich-816	134	11	the	the	DET
biomedich-816	134	12	faculty	faculty	NOUN
biomedich-816	134	13	of	of	ADP
biomedich-816	134	14	medicine	medicine	NOUN
biomedich-816	134	15	at	at	ADP
biomedich-816	134	16	universitas	universitas	PROPN
biomedich-816	134	17	ahmad	ahmad	PROPN
biomedich-816	134	18	dahlan	dahlan	PROPN
biomedich-816	134	19	,	,	PUNCT
biomedich-816	134	20	yogyakarta	yogyakarta	PROPN
biomedich-816	134	21	,	,	PUNCT
biomedich-816	134	22	indonesia	indonesia	PROPN
biomedich-816	134	23	.	.	PUNCT
biomedich-816	135	1	authors	author	NOUN
biomedich-816	135	2	’	'	PUNCT
biomedich-816	135	3	contributions	contribution	NOUN
biomedich-816	135	4	:	:	PUNCT
biomedich-816	135	5	all	all	DET
biomedich-816	135	6	authors	author	NOUN
biomedich-816	135	7	contributed	contribute	VERB
biomedich-816	135	8	equally	equally	ADV
biomedich-816	135	9	to	to	ADP
biomedich-816	135	10	the	the	DET
biomedich-816	135	11	conception	conception	NOUN
biomedich-816	135	12	of	of	ADP
biomedich-816	135	13	the	the	DET
biomedich-816	135	14	study	study	NOUN
biomedich-816	135	15	,	,	PUNCT
biomedich-816	135	16	data	data	NOUN
biomedich-816	135	17	acquisition	acquisition	NOUN
biomedich-816	135	18	,	,	PUNCT
biomedich-816	135	19	analysis	analysis	NOUN
biomedich-816	135	20	,	,	PUNCT
biomedich-816	135	21	and	and	CCONJ
biomedich-816	135	22	interpretation	interpretation	NOUN
biomedich-816	135	23	for	for	ADP
biomedich-816	135	24	the	the	DET
biomedich-816	135	25	manuscript	manuscript	NOUN
biomedich-816	135	26	.	.	PUNCT
biomedich-816	136	1	competing	compete	VERB
biomedich-816	136	2	interests	interest	NOUN
biomedich-816	136	3	:	:	PUNCT
biomedich-816	136	4	the	the	DET
biomedich-816	136	5	authors	author	NOUN
biomedich-816	136	6	declare	declare	VERB
biomedich-816	136	7	no	no	DET
biomedich-816	136	8	competing	compete	VERB
biomedich-816	136	9	of	of	ADP
biomedich-816	136	10	interests	interest	NOUN
biomedich-816	136	11	.	.	PUNCT
biomedich-816	137	1	funding	funding	NOUN
biomedich-816	137	2	:	:	PUNCT
biomedich-816	137	3	this	this	DET
biomedich-816	137	4	research	research	NOUN
biomedich-816	137	5	received	receive	VERB
biomedich-816	137	6	no	no	DET
biomedich-816	137	7	external	external	ADJ
biomedich-816	137	8	funding	funding	NOUN
biomedich-816	137	9	.	.	PUNCT
biomedich-816	138	1	references	reference	NOUN
biomedich-816	138	2	adam	adam	PROPN
biomedich-816	138	3	,	,	PUNCT
biomedich-816	138	4	m.	m.	NOUN
biomedich-816	138	5	,	,	PUNCT
biomedich-816	138	6	schikowski	schikowski	ADJ
biomedich-816	138	7	,	,	PUNCT
biomedich-816	138	8	t.	t.	PROPN
biomedich-816	138	9	,	,	PUNCT
biomedich-816	138	10	carsin	carsin	PROPN
biomedich-816	138	11	,	,	PUNCT
biomedich-816	138	12	a.	a.	PROPN
biomedich-816	138	13	e.	e.	PROPN
biomedich-816	138	14	,	,	PUNCT
biomedich-816	138	15	cai	cai	PROPN
biomedich-816	138	16	,	,	PUNCT
biomedich-816	138	17	y.	y.	PROPN
biomedich-816	138	18	,	,	PUNCT
biomedich-816	138	19	jacquemin	jacquemin	PROPN
biomedich-816	138	20	,	,	PUNCT
biomedich-816	138	21	b.	b.	PROPN
biomedich-816	138	22	,	,	PUNCT
biomedich-816	138	23	sanchez	sanchez	PROPN
biomedich-816	138	24	,	,	PUNCT
biomedich-816	138	25	m.	m.	NOUN
biomedich-816	138	26	,	,	PUNCT
biomedich-816	138	27	vierkötter	vierkötter	NOUN
biomedich-816	138	28	,	,	PUNCT
biomedich-816	138	29	a.	a.	NOUN
biomedich-816	138	30	,	,	PUNCT
biomedich-816	138	31	marcon	marcon	PROPN
biomedich-816	138	32	,	,	PUNCT
biomedich-816	138	33	a.	a.	PROPN
biomedich-816	138	34	,	,	PUNCT
biomedich-816	138	35	keidel	keidel	PROPN
biomedich-816	138	36	,	,	PUNCT
biomedich-816	138	37	d.	d.	PROPN
biomedich-816	138	38	,	,	PUNCT
biomedich-816	138	39	sugiri	sugiri	PROPN
biomedich-816	138	40	,	,	PUNCT
biomedich-816	138	41	d.	d.	PROPN
biomedich-816	138	42	,	,	PUNCT
biomedich-816	138	43	al	al	PROPN
biomedich-816	138	44	kanani	kanani	PROPN
biomedich-816	138	45	,	,	PUNCT
biomedich-816	138	46	z.	z.	PROPN
biomedich-816	138	47	,	,	PUNCT
biomedich-816	138	48	nadif	nadif	ADV
biomedich-816	138	49	,	,	PUNCT
biomedich-816	138	50	r.	r.	PROPN
biomedich-816	138	51	,	,	PUNCT
biomedich-816	138	52	siroux	siroux	NOUN
biomedich-816	138	53	,	,	PUNCT
biomedich-816	138	54	v.	v.	ADV
biomedich-816	138	55	,	,	PUNCT
biomedich-816	138	56	hardy	hardy	ADJ
biomedich-816	138	57	,	,	PUNCT
biomedich-816	138	58	r.	r.	PROPN
biomedich-816	138	59	,	,	PUNCT
biomedich-816	138	60	kuh	kuh	PROPN
biomedich-816	138	61	,	,	PUNCT
biomedich-816	138	62	d.	d.	PROPN
biomedich-816	138	63	,	,	PUNCT
biomedich-816	138	64	rochat	rochat	PROPN
biomedich-816	138	65	,	,	PUNCT
biomedich-816	138	66	t.	t.	PROPN
biomedich-816	138	67	,	,	PUNCT
biomedich-816	138	68	bridevaux	bridevaux	PROPN
biomedich-816	138	69	,	,	PUNCT
biomedich-816	138	70	p.	p.	PROPN
biomedich-816	138	71	o.	o.	PROPN
biomedich-816	138	72	,	,	PUNCT
biomedich-816	138	73	eeftens	eeften	NOUN
biomedich-816	138	74	,	,	PUNCT
biomedich-816	138	75	m.	m.	NOUN
biomedich-816	138	76	,	,	PUNCT
biomedich-816	138	77	tsai	tsai	PROPN
biomedich-816	138	78	,	,	PUNCT
biomedich-816	138	79	m.	m.	NOUN
biomedich-816	138	80	y.	y.	PROPN
biomedich-816	138	81	,	,	PUNCT
biomedich-816	138	82	…	…	PUNCT
biomedich-816	138	83	probst	probst	NOUN
biomedich-816	138	84	-	-	PUNCT
biomedich-816	138	85	hensch	hensch	NOUN
biomedich-816	138	86	,	,	PUNCT
biomedich-816	138	87	n.	n.	NOUN
biomedich-816	138	88	(	(	PUNCT
biomedich-816	138	89	2015	2015	NUM
biomedich-816	138	90	)	)	PUNCT
biomedich-816	138	91	.	.	PUNCT
biomedich-816	139	1	adult	adult	NOUN
biomedich-816	139	2	lung	lung	NOUN
biomedich-816	139	3	function	function	NOUN
biomedich-816	139	4	and	and	CCONJ
biomedich-816	139	5	long	long	ADJ
biomedich-816	139	6	-	-	PUNCT
biomedich-816	139	7	term	term	NOUN
biomedich-816	139	8	air	air	NOUN
biomedich-816	139	9	pollution	pollution	NOUN
biomedich-816	139	10	exposure	exposure	NOUN
biomedich-816	139	11	.	.	PUNCT
biomedich-816	140	1	escape	escape	NOUN
biomedich-816	140	2	:	:	PUNCT
biomedich-816	140	3	a	a	DET
biomedich-816	140	4	multicentre	multicentre	NOUN
biomedich-816	140	5	cohort	cohort	NOUN
biomedich-816	140	6	study	study	NOUN
biomedich-816	140	7	and	and	CCONJ
biomedich-816	140	8	meta	meta	ADJ
biomedich-816	140	9	-	-	PUNCT
biomedich-816	140	10	analysis	analysis	NOUN
biomedich-816	140	11	.	.	PUNCT
biomedich-816	141	1	european	european	ADJ
biomedich-816	141	2	respiratory	respiratory	ADJ
biomedich-816	141	3	journal	journal	PROPN
biomedich-816	141	4	,	,	PUNCT
biomedich-816	141	5	45(1	45(1	NOUN
biomedich-816	141	6	)	)	PUNCT
biomedich-816	141	7	,	,	PUNCT
biomedich-816	141	8	38	38	NUM
biomedich-816	141	9	–	–	SYM
biomedich-816	141	10	50	50	NUM
biomedich-816	141	11	.	.	PUNCT
biomedich-816	141	12	https://doi.org/10.1183/09031936.00130014	https://doi.org/10.1183/09031936.00130014	VERB
biomedich-816	141	13	adikusuma	adikusuma	PROPN
biomedich-816	141	14	,	,	PUNCT
biomedich-816	141	15	w.	w.	PROPN
biomedich-816	141	16	,	,	PUNCT
biomedich-816	141	17	irham	irham	PROPN
biomedich-816	141	18	,	,	PUNCT
biomedich-816	141	19	l.	l.	PROPN
biomedich-816	141	20	m.	m.	PROPN
biomedich-816	141	21	,	,	PUNCT
biomedich-816	141	22	chou	chou	PROPN
biomedich-816	141	23	,	,	PUNCT
biomedich-816	141	24	w.	w.	PROPN
biomedich-816	141	25	h.	h.	PROPN
biomedich-816	141	26	,	,	PUNCT
biomedich-816	141	27	wong	wong	PROPN
biomedich-816	141	28	,	,	PUNCT
biomedich-816	141	29	h.	h.	PROPN
biomedich-816	141	30	s.	s.	PROPN
biomedich-816	141	31	c.	c.	PROPN
biomedich-816	141	32	,	,	PUNCT
biomedich-816	141	33	mugiyanto	mugiyanto	PROPN
biomedich-816	141	34	,	,	PUNCT
biomedich-816	141	35	e.	e.	PROPN
biomedich-816	141	36	,	,	PUNCT
biomedich-816	141	37	ting	ting	PROPN
biomedich-816	141	38	,	,	PUNCT
biomedich-816	141	39	j.	j.	PROPN
biomedich-816	141	40	,	,	PUNCT
biomedich-816	141	41	perwitasari	perwitasari	PROPN
biomedich-816	141	42	,	,	PUNCT
biomedich-816	141	43	d.	d.	PROPN
biomedich-816	141	44	a.	a.	PROPN
biomedich-816	141	45	,	,	PUNCT
biomedich-816	141	46	chang	chang	PROPN
biomedich-816	141	47	,	,	PUNCT
biomedich-816	141	48	w.	w.	PROPN
biomedich-816	141	49	p.	p.	PROPN
biomedich-816	141	50	,	,	PUNCT
biomedich-816	141	51	&	&	CCONJ
biomedich-816	141	52	chang	chang	PROPN
biomedich-816	141	53	,	,	PUNCT
biomedich-816	141	54	w.	w.	PROPN
biomedich-816	141	55	c.	c.	PROPN
biomedich-816	141	56	(	(	PUNCT
biomedich-816	141	57	2021	2021	NUM
biomedich-816	141	58	)	)	PUNCT
biomedich-816	141	59	.	.	PUNCT
biomedich-816	142	1	drug	drug	NOUN
biomedich-816	142	2	repurposing	repurpose	VERB
biomedich-816	142	3	for	for	ADP
biomedich-816	142	4	atopic	atopic	NOUN
biomedich-816	142	5	dermatitis	dermatitis	NOUN
biomedich-816	142	6	by	by	ADP
biomedich-816	142	7	integration	integration	NOUN
biomedich-816	142	8	of	of	ADP
biomedich-816	142	9	gene	gene	NOUN
biomedich-816	142	10	networking	networking	NOUN
biomedich-816	142	11	and	and	CCONJ
biomedich-816	142	12	genomic	genomic	ADJ
biomedich-816	142	13	information	information	NOUN
biomedich-816	142	14	.	.	PUNCT
biomedich-816	143	1	frontiers	frontier	NOUN
biomedich-816	143	2	in	in	ADP
biomedich-816	143	3	immunology	immunology	NOUN
biomedich-816	143	4	,	,	PUNCT
biomedich-816	143	5	12	12	NUM
biomedich-816	143	6	.	.	PUNCT
biomedich-816	144	1	https://doi.org/10.3389/fimmu.2021.724277	https://doi.org/10.3389/fimmu.2021.724277	NOUN
biomedich-816	144	2	aldabayan	aldabayan	ADJ
biomedich-816	144	3	,	,	PUNCT
biomedich-816	144	4	y.	y.	PROPN
biomedich-816	144	5	s.	s.	PROPN
biomedich-816	144	6	(	(	PUNCT
biomedich-816	144	7	2025	2025	NUM
biomedich-816	144	8	)	)	PUNCT
biomedich-816	144	9	.	.	PUNCT
biomedich-816	145	1	effect	effect	NOUN
biomedich-816	145	2	of	of	ADP
biomedich-816	145	3	artificial	artificial	ADJ
biomedich-816	145	4	food	food	NOUN
biomedich-816	145	5	additives	additive	NOUN
biomedich-816	145	6	on	on	ADP
biomedich-816	145	7	lung	lung	NOUN
biomedich-816	145	8	health	health	NOUN
biomedich-816	145	9	—	—	PUNCT
biomedich-816	145	10	an	an	DET
biomedich-816	145	11	overview	overview	NOUN
biomedich-816	145	12	.	.	PUNCT
biomedich-816	146	1	medicina	medicina	NOUN
biomedich-816	146	2	,	,	PUNCT
biomedich-816	146	3	61(4	61(4	NUM
biomedich-816	146	4	)	)	PUNCT
biomedich-816	146	5	,	,	PUNCT
biomedich-816	146	6	684	684	NUM
biomedich-816	146	7	.	.	PUNCT
biomedich-816	147	1	https://doi.org/10.3390/medicina61040684	https://doi.org/10.3390/medicina61040684	PROPN
biomedich-816	147	2	burbelo	burbelo	PROPN
biomedich-816	147	3	,	,	PUNCT
biomedich-816	147	4	p.	p.	PROPN
biomedich-816	147	5	d.	d.	PROPN
biomedich-816	147	6	,	,	PUNCT
biomedich-816	147	7	ambatipudi	ambatipudi	PROPN
biomedich-816	147	8	,	,	PUNCT
biomedich-816	147	9	k.	k.	PROPN
biomedich-816	147	10	,	,	PUNCT
biomedich-816	147	11	&	&	CCONJ
biomedich-816	147	12	alevizos	alevizos	PROPN
biomedich-816	147	13	,	,	PUNCT
biomedich-816	147	14	i.	i.	PROPN
biomedich-816	147	15	(	(	PUNCT
biomedich-816	147	16	2014	2014	NUM
biomedich-816	147	17	)	)	PUNCT
biomedich-816	147	18	.	.	PUNCT
biomedich-816	148	1	genomewide	genomewide	PROPN
biomedich-816	148	2	association	association	PROPN
biomedich-816	148	3	studies	study	NOUN
biomedich-816	148	4	in	in	ADP
biomedich-816	148	5	sjögren	sjögren	PROPN
biomedich-816	148	6	’s	’s	PART
biomedich-816	148	7	syndrome	syndrome	NOUN
biomedich-816	148	8	:	:	PUNCT
biomedich-816	148	9	what	what	PRON
biomedich-816	148	10	do	do	AUX
biomedich-816	148	11	the	the	DET
biomedich-816	148	12	genes	gene	NOUN
biomedich-816	148	13	tell	tell	VERB
biomedich-816	148	14	us	we	PRON
biomedich-816	148	15	about	about	ADP
biomedich-816	148	16	disease	disease	NOUN
biomedich-816	148	17	pathogenesis	pathogenesis	NOUN
biomedich-816	148	18	?	?	PUNCT
biomedich-816	149	1	in	in	ADP
biomedich-816	149	2	autoimmunity	autoimmunity	NOUN
biomedich-816	149	3	reviews	review	NOUN
biomedich-816	149	4	(	(	PUNCT
biomedich-816	149	5	vol	vol	NOUN
biomedich-816	149	6	.	.	PROPN
biomedich-816	149	7	13	13	NUM
biomedich-816	149	8	,	,	PUNCT
biomedich-816	149	9	issue	issue	NOUN
biomedich-816	149	10	7	7	NUM
biomedich-816	149	11	,	,	PUNCT
biomedich-816	149	12	pp	pp	ADJ
biomedich-816	149	13	.	.	PUNCT
biomedich-816	150	1	756–761	756–761	NUM
biomedich-816	150	2	)	)	PUNCT
biomedich-816	150	3	.	.	PUNCT
biomedich-816	151	1	elsevier	elsevier	NOUN
biomedich-816	151	2	.	.	PUNCT
biomedich-816	152	1	https://doi.org/10.1016/j.autrev.2014.02.002	https://doi.org/10.1016/j.autrev.2014.02.002	NOUN
biomedich-816	152	2	camarena	camarena	NOUN
biomedich-816	152	3	,	,	PUNCT
biomedich-816	152	4	á	á	PROPN
biomedich-816	152	5	.	.	PROPN
biomedich-816	152	6	,	,	PUNCT
biomedich-816	152	7	aquino	aquino	NOUN
biomedich-816	152	8	-	-	PUNCT
biomedich-816	152	9	galvez	galvez	PROPN
biomedich-816	152	10	,	,	PUNCT
biomedich-816	152	11	a.	a.	NOUN
biomedich-816	152	12	,	,	PUNCT
biomedich-816	152	13	falfán	falfán	NOUN
biomedich-816	152	14	-	-	PUNCT
biomedich-816	152	15	valencia	valencia	NOUN
biomedich-816	152	16	,	,	PUNCT
biomedich-816	152	17	r.	r.	PROPN
biomedich-816	152	18	,	,	PUNCT
biomedich-816	152	19	sánchez	sánchez	PROPN
biomedich-816	152	20	,	,	PUNCT
biomedich-816	152	21	g.	g.	PROPN
biomedich-816	152	22	,	,	PUNCT
biomedich-816	152	23	montaño	montaño	NOUN
biomedich-816	152	24	,	,	PUNCT
biomedich-816	152	25	m.	m.	NOUN
biomedich-816	152	26	,	,	PUNCT
biomedich-816	152	27	ramos	ramos	PROPN
biomedich-816	152	28	,	,	PUNCT
biomedich-816	152	29	c.	c.	PROPN
biomedich-816	152	30	,	,	PUNCT
biomedich-816	152	31	juárez	juárez	PROPN
biomedich-816	152	32	,	,	PUNCT
biomedich-816	152	33	a.	a.	NOUN
biomedich-816	152	34	,	,	PUNCT
biomedich-816	152	35	garcía	garcía	NOUN
biomedich-816	152	36	-	-	PUNCT
biomedich-816	152	37	de	de	NOUN
biomedich-816	152	38	-	-	NOUN
biomedich-816	152	39	alba	alba	PROPN
biomedich-816	152	40	,	,	PUNCT
biomedich-816	152	41	c.	c.	PROPN
biomedich-816	152	42	,	,	PUNCT
biomedich-816	152	43	granados	granados	PROPN
biomedich-816	152	44	,	,	PUNCT
biomedich-816	152	45	j.	j.	PROPN
biomedich-816	152	46	,	,	PUNCT
biomedich-816	152	47	&	&	CCONJ
biomedich-816	152	48	selman	selman	PROPN
biomedich-816	152	49	,	,	PUNCT
biomedich-816	152	50	m.	m.	NOUN
biomedich-816	152	51	(	(	PUNCT
biomedich-816	152	52	2010	2010	NUM
biomedich-816	152	53	)	)	PUNCT
biomedich-816	152	54	.	.	PUNCT
biomedich-816	153	1	psmb8	psmb8	NOUN
biomedich-816	153	2	(	(	PUNCT
biomedich-816	153	3	lmp7	lmp7	PROPN
biomedich-816	153	4	)	)	PUNCT
biomedich-816	153	5	but	but	CCONJ
biomedich-816	153	6	not	not	PART
biomedich-816	153	7	psmb9	psmb9	NOUN
biomedich-816	153	8	(	(	PUNCT
biomedich-816	153	9	lmp2	lmp2	PROPN
biomedich-816	153	10	)	)	PUNCT
biomedich-816	153	11	gene	gene	NOUN
biomedich-816	153	12	polymorphisms	polymorphism	NOUN
biomedich-816	153	13	are	be	AUX
biomedich-816	153	14	associated	associate	VERB
biomedich-816	153	15	to	to	ADP
biomedich-816	153	16	pigeon	pigeon	NOUN
biomedich-816	153	17	breeder	breeder	NOUN
biomedich-816	153	18	’s	’s	PART
biomedich-816	153	19	hypersensitivity	hypersensitivity	NOUN
biomedich-816	153	20	pneumonitis	pneumonitis	NOUN
biomedich-816	153	21	.	.	PUNCT
biomedich-816	154	1	respiratory	respiratory	ADJ
biomedich-816	154	2	medicine	medicine	NOUN
biomedich-816	154	3	,	,	PUNCT
biomedich-816	154	4	104(6	104(6	NUM
biomedich-816	154	5	)	)	PUNCT
biomedich-816	154	6	,	,	PUNCT
biomedich-816	154	7	889–894	889–894	NUM
biomedich-816	154	8	.	.	PUNCT
biomedich-816	155	1	https://doi.org/10.1016/j.rmed.2010.01.014	https://doi.org/10.1016/j.rmed.2010.01.014	PROPN
biomedich-816	155	2	eckhardt	eckhardt	PROPN
biomedich-816	155	3	,	,	PUNCT
biomedich-816	155	4	c.	c.	PROPN
biomedich-816	155	5	m.	m.	NOUN
biomedich-816	155	6	,	,	PUNCT
biomedich-816	155	7	&	&	CCONJ
biomedich-816	155	8	wu	wu	PROPN
biomedich-816	155	9	,	,	PUNCT
biomedich-816	155	10	h.	h.	PROPN
biomedich-816	155	11	(	(	PUNCT
biomedich-816	155	12	2021	2021	NUM
biomedich-816	155	13	)	)	PUNCT
biomedich-816	155	14	.	.	PUNCT
biomedich-816	156	1	environmental	environmental	ADJ
biomedich-816	156	2	exposures	exposure	NOUN
biomedich-816	156	3	and	and	CCONJ
biomedich-816	156	4	lung	lung	NOUN
biomedich-816	156	5	aging	aging	NOUN
biomedich-816	156	6	:	:	PUNCT
biomedich-816	156	7	molecular	molecular	ADJ
biomedich-816	156	8	mechanisms	mechanism	NOUN
biomedich-816	156	9	and	and	CCONJ
biomedich-816	156	10	implications	implication	NOUN
biomedich-816	156	11	for	for	ADP
biomedich-816	156	12	farid	farid	PROPN
biomedich-816	156	13	et	et	PROPN
biomedich-816	156	14	al	al	PROPN
biomedich-816	156	15	.	.	PROPN
biomedich-816	156	16	–	–	PUNCT
biomedich-816	156	17	investigating	investigate	VERB
biomedich-816	156	18	genetic	genetic	ADJ
biomedich-816	156	19	vulnerability	vulnerability	NOUN
biomedich-816	156	20	to	to	ADP
biomedich-816	156	21	environmental	environmental	ADJ
biomedich-816	156	22	exposures	exposure	NOUN
biomedich-816	156	23	…	…	PUNCT
biomedich-816	156	24	723	723	NUM
biomedich-816	156	25	improving	improve	VERB
biomedich-816	156	26	respiratory	respiratory	ADJ
biomedich-816	156	27	health	health	NOUN
biomedich-816	156	28	.	.	PUNCT
biomedich-816	157	1	in	in	ADP
biomedich-816	157	2	current	current	ADJ
biomedich-816	157	3	environmental	environmental	ADJ
biomedich-816	157	4	health	health	NOUN
biomedich-816	157	5	reports	report	NOUN
biomedich-816	157	6	(	(	PUNCT
biomedich-816	157	7	vol	vol	NOUN
biomedich-816	157	8	.	.	NOUN
biomedich-816	157	9	8	8	NUM
biomedich-816	157	10	,	,	PUNCT
biomedich-816	157	11	issue	issue	NOUN
biomedich-816	157	12	4	4	NUM
biomedich-816	157	13	,	,	PUNCT
biomedich-816	157	14	pp	pp	ADJ
biomedich-816	157	15	.	.	PUNCT
biomedich-816	158	1	281–293	281–293	NUM
biomedich-816	158	2	)	)	PUNCT
biomedich-816	158	3	.	.	PUNCT
biomedich-816	159	1	springer	springer	NOUN
biomedich-816	159	2	science	science	PROPN
biomedich-816	159	3	and	and	CCONJ
biomedich-816	159	4	business	business	NOUN
biomedich-816	159	5	media	medium	NOUN
biomedich-816	159	6	deutschland	deutschland	PROPN
biomedich-816	159	7	gmbh	gmbh	PROPN
biomedich-816	159	8	.	.	PUNCT
biomedich-816	160	1	https://doi.org/10.1007/s40572-021-00328-2	https://doi.org/10.1007/s40572-021-00328-2	NUM
biomedich-816	160	2	harber	harber	PROPN
biomedich-816	160	3	,	,	PUNCT
biomedich-816	160	4	p.	p.	NOUN
biomedich-816	160	5	,	,	PUNCT
biomedich-816	160	6	redlich	redlich	PROPN
biomedich-816	160	7	,	,	PUNCT
biomedich-816	160	8	c.	c.	PROPN
biomedich-816	160	9	a.	a.	PROPN
biomedich-816	160	10	,	,	PUNCT
biomedich-816	160	11	&	&	CCONJ
biomedich-816	160	12	henneberger	henneberger	PROPN
biomedich-816	160	13	,	,	PUNCT
biomedich-816	160	14	p.	p.	PROPN
biomedich-816	160	15	k.	k.	PROPN
biomedich-816	161	1	(	(	PUNCT
biomedich-816	161	2	2016	2016	NUM
biomedich-816	161	3	)	)	PUNCT
biomedich-816	161	4	.	.	PUNCT
biomedich-816	162	1	workrelated	workrelate	VERB
biomedich-816	162	2	lung	lung	NOUN
biomedich-816	162	3	diseases	disease	NOUN
biomedich-816	162	4	.	.	PUNCT
biomedich-816	163	1	american	american	ADJ
biomedich-816	163	2	journal	journal	PROPN
biomedich-816	163	3	of	of	ADP
biomedich-816	163	4	respiratory	respiratory	ADJ
biomedich-816	163	5	and	and	CCONJ
biomedich-816	163	6	critical	critical	ADJ
biomedich-816	163	7	care	care	NOUN
biomedich-816	163	8	medicine	medicine	NOUN
biomedich-816	163	9	,	,	PUNCT
biomedich-816	163	10	193(2	193(2	NUM
biomedich-816	163	11	)	)	PUNCT
biomedich-816	163	12	,	,	PUNCT
biomedich-816	163	13	p3	p3	PROPN
biomedich-816	163	14	–	–	PUNCT
biomedich-816	163	15	p4	p4	ADJ
biomedich-816	163	16	.	.	PUNCT
biomedich-816	164	1	https://doi.org/10.1164/rccm.1932p3	https://doi.org/10.1164/rccm.1932p3	VERB
biomedich-816	164	2	he	he	PRON
biomedich-816	164	3	,	,	PUNCT
biomedich-816	164	4	j.	j.	PROPN
biomedich-816	164	5	,	,	PUNCT
biomedich-816	164	6	li	li	PROPN
biomedich-816	164	7	,	,	PUNCT
biomedich-816	164	8	x.	x.	PROPN
biomedich-816	164	9	,	,	PUNCT
biomedich-816	164	10	&	&	CCONJ
biomedich-816	164	11	yu	yu	PROPN
biomedich-816	164	12	,	,	PUNCT
biomedich-816	164	13	m.	m.	NOUN
biomedich-816	164	14	(	(	PUNCT
biomedich-816	164	15	2022	2022	NUM
biomedich-816	164	16	)	)	PUNCT
biomedich-816	164	17	.	.	PUNCT
biomedich-816	165	1	bioinformatics	bioinformatics	NOUN
biomedich-816	165	2	analysis	analysis	NOUN
biomedich-816	165	3	identifies	identify	VERB
biomedich-816	165	4	potential	potential	ADJ
biomedich-816	165	5	ferroptosis	ferroptosis	NOUN
biomedich-816	165	6	key	key	ADJ
biomedich-816	165	7	genes	gene	NOUN
biomedich-816	165	8	in	in	ADP
biomedich-816	165	9	the	the	DET
biomedich-816	165	10	pathogenesis	pathogenesis	NOUN
biomedich-816	165	11	of	of	ADP
biomedich-816	165	12	pulmonary	pulmonary	ADJ
biomedich-816	165	13	fibrosis	fibrosis	NOUN
biomedich-816	165	14	.	.	PUNCT
biomedich-816	166	1	frontiers	frontier	NOUN
biomedich-816	166	2	in	in	ADP
biomedich-816	166	3	genetics	genetic	NOUN
biomedich-816	166	4	,	,	PUNCT
biomedich-816	166	5	12	12	NUM
biomedich-816	166	6	.	.	PUNCT
biomedich-816	167	1	https://doi.org/10.3389/fgene.2021.788417	https://doi.org/10.3389/fgene.2021.788417	PRON
biomedich-816	167	2	irham	irham	NOUN
biomedich-816	167	3	,	,	PUNCT
biomedich-816	167	4	l.	l.	PROPN
biomedich-816	167	5	m.	m.	PROPN
biomedich-816	167	6	,	,	PUNCT
biomedich-816	167	7	adikusuma	adikusuma	PROPN
biomedich-816	167	8	,	,	PUNCT
biomedich-816	167	9	w.	w.	PROPN
biomedich-816	167	10	,	,	PUNCT
biomedich-816	167	11	lolita	lolita	PROPN
biomedich-816	167	12	,	,	PUNCT
biomedich-816	167	13	l.	l.	PROPN
biomedich-816	167	14	,	,	PUNCT
biomedich-816	167	15	puspitaningrum	puspitaningrum	PROPN
biomedich-816	167	16	,	,	PUNCT
biomedich-816	167	17	a.	a.	NOUN
biomedich-816	167	18	n.	n.	NOUN
biomedich-816	167	19	,	,	PUNCT
biomedich-816	167	20	afief	afief	ADJ
biomedich-816	167	21	,	,	PUNCT
biomedich-816	167	22	a.	a.	PROPN
biomedich-816	167	23	r.	r.	PROPN
biomedich-816	167	24	,	,	PUNCT
biomedich-816	167	25	sarasmita	sarasmita	PROPN
biomedich-816	167	26	,	,	PUNCT
biomedich-816	167	27	m.	m.	NOUN
biomedich-816	167	28	a.	a.	PROPN
biomedich-816	167	29	,	,	PUNCT
biomedich-816	167	30	dania	dania	PROPN
biomedich-816	167	31	,	,	PUNCT
biomedich-816	167	32	h.	h.	PROPN
biomedich-816	167	33	,	,	PUNCT
biomedich-816	167	34	khairi	khairi	PROPN
biomedich-816	167	35	,	,	PUNCT
biomedich-816	167	36	s.	s.	PROPN
biomedich-816	167	37	,	,	PUNCT
biomedich-816	167	38	djalilah	djalilah	PROPN
biomedich-816	167	39	,	,	PUNCT
biomedich-816	167	40	g.	g.	PROPN
biomedich-816	167	41	n.	n.	PROPN
biomedich-816	167	42	,	,	PUNCT
biomedich-816	167	43	purwanto	purwanto	PROPN
biomedich-816	167	44	,	,	PUNCT
biomedich-816	167	45	b.	b.	PROPN
biomedich-816	167	46	d.	d.	PROPN
biomedich-816	167	47	,	,	PUNCT
biomedich-816	167	48	&	&	CCONJ
biomedich-816	167	49	chong	chong	PROPN
biomedich-816	167	50	,	,	PUNCT
biomedich-816	167	51	r.	r.	PROPN
biomedich-816	167	52	(	(	PUNCT
biomedich-816	167	53	2023	2023	NUM
biomedich-816	167	54	)	)	PUNCT
biomedich-816	167	55	.	.	PUNCT
biomedich-816	168	1	investigation	investigation	NOUN
biomedich-816	168	2	of	of	ADP
biomedich-816	168	3	susceptibility	susceptibility	NOUN
biomedich-816	168	4	genes	gene	NOUN
biomedich-816	168	5	for	for	ADP
biomedich-816	168	6	chickenpox	chickenpox	NOUN
biomedich-816	168	7	disease	disease	NOUN
biomedich-816	168	8	across	across	ADP
biomedich-816	168	9	multiple	multiple	ADJ
biomedich-816	168	10	continents	continent	NOUN
biomedich-816	168	11	.	.	PUNCT
biomedich-816	169	1	biochemistry	biochemistry	NOUN
biomedich-816	169	2	and	and	CCONJ
biomedich-816	169	3	biophysics	biophysic	NOUN
biomedich-816	169	4	reports	report	NOUN
biomedich-816	169	5	,	,	PUNCT
biomedich-816	169	6	33	33	NUM
biomedich-816	169	7	.	.	PUNCT
biomedich-816	170	1	https://doi.org/10.1016/j.bbrep.2022.101419	https://doi.org/10.1016/j.bbrep.2022.101419	PROPN
biomedich-816	170	2	kim	kim	PROPN
biomedich-816	170	3	,	,	PUNCT
biomedich-816	170	4	y.	y.	PROPN
biomedich-816	170	5	a.	a.	PROPN
biomedich-816	170	6	,	,	PUNCT
biomedich-816	170	7	hodzic	hodzic	PROPN
biomedich-816	170	8	,	,	PUNCT
biomedich-816	170	9	e.	e.	PROPN
biomedich-816	170	10	,	,	PUNCT
biomedich-816	170	11	amgalan	amgalan	PROPN
biomedich-816	170	12	,	,	PUNCT
biomedich-816	170	13	b.	b.	PROPN
biomedich-816	170	14	,	,	PUNCT
biomedich-816	170	15	saslafsky	saslafsky	PROPN
biomedich-816	170	16	,	,	PUNCT
biomedich-816	170	17	a.	a.	NOUN
biomedich-816	170	18	,	,	PUNCT
biomedich-816	170	19	wojtowicz	wojtowicz	VERB
biomedich-816	170	20	,	,	PUNCT
biomedich-816	170	21	d.	d.	PROPN
biomedich-816	170	22	,	,	PUNCT
biomedich-816	170	23	&	&	CCONJ
biomedich-816	170	24	przytycka	przytycka	PROPN
biomedich-816	170	25	,	,	PUNCT
biomedich-816	170	26	t.	t.	NOUN
biomedich-816	170	27	m.	m.	NOUN
biomedich-816	170	28	(	(	PUNCT
biomedich-816	170	29	2022	2022	NUM
biomedich-816	170	30	)	)	PUNCT
biomedich-816	170	31	.	.	PUNCT
biomedich-816	171	1	mutational	mutational	ADJ
biomedich-816	171	2	signatures	signature	NOUN
biomedich-816	171	3	as	as	ADP
biomedich-816	171	4	sensors	sensor	NOUN
biomedich-816	171	5	of	of	ADP
biomedich-816	171	6	environmental	environmental	ADJ
biomedich-816	171	7	exposures	exposure	NOUN
biomedich-816	171	8	:	:	PUNCT
biomedich-816	171	9	analysis	analysis	NOUN
biomedich-816	171	10	of	of	ADP
biomedich-816	171	11	smokinginduced	smokinginduce	VERB
biomedich-816	171	12	lung	lung	NOUN
biomedich-816	171	13	tissue	tissue	NOUN
biomedich-816	171	14	remodeling	remodeling	NOUN
biomedich-816	171	15	.	.	PUNCT
biomedich-816	172	1	biomolecules	biomolecule	NOUN
biomedich-816	172	2	,	,	PUNCT
biomedich-816	172	3	12(10	12(10	NUM
biomedich-816	172	4	)	)	PUNCT
biomedich-816	172	5	.	.	PUNCT
biomedich-816	173	1	https://doi.org/10.3390/biom12101384	https://doi.org/10.3390/biom12101384	PROPN
biomedich-816	173	2	liu	liu	PROPN
biomedich-816	173	3	,	,	PUNCT
biomedich-816	173	4	y.	y.	PROPN
biomedich-816	173	5	,	,	PUNCT
biomedich-816	173	6	ramot	ramot	NOUN
biomedich-816	173	7	,	,	PUNCT
biomedich-816	173	8	y.	y.	PROPN
biomedich-816	173	9	,	,	PUNCT
biomedich-816	173	10	torrelo	torrelo	NOUN
biomedich-816	173	11	,	,	PUNCT
biomedich-816	173	12	a.	a.	NOUN
biomedich-816	173	13	,	,	PUNCT
biomedich-816	173	14	paller	paller	NOUN
biomedich-816	173	15	,	,	PUNCT
biomedich-816	173	16	a.	a.	PROPN
biomedich-816	173	17	s.	s.	PROPN
biomedich-816	173	18	,	,	PUNCT
biomedich-816	173	19	si	si	PROPN
biomedich-816	173	20	,	,	PUNCT
biomedich-816	173	21	n.	n.	NOUN
biomedich-816	173	22	,	,	PUNCT
biomedich-816	173	23	babay	babay	PROPN
biomedich-816	173	24	,	,	PUNCT
biomedich-816	173	25	s.	s.	PROPN
biomedich-816	173	26	,	,	PUNCT
biomedich-816	173	27	kim	kim	PROPN
biomedich-816	173	28	,	,	PUNCT
biomedich-816	173	29	p.	p.	PROPN
biomedich-816	173	30	w.	w.	PROPN
biomedich-816	173	31	,	,	PUNCT
biomedich-816	173	32	sheikh	sheikh	PROPN
biomedich-816	173	33	,	,	PUNCT
biomedich-816	173	34	a.	a.	PROPN
biomedich-816	173	35	,	,	PUNCT
biomedich-816	173	36	lee	lee	PROPN
biomedich-816	173	37	,	,	PUNCT
biomedich-816	173	38	c.	c.	PROPN
biomedich-816	173	39	c.	c.	PROPN
biomedich-816	173	40	r.	r.	PROPN
biomedich-816	173	41	,	,	PUNCT
biomedich-816	173	42	chen	chen	PROPN
biomedich-816	173	43	,	,	PUNCT
biomedich-816	173	44	y.	y.	PROPN
biomedich-816	173	45	,	,	PUNCT
biomedich-816	173	46	vera	vera	NOUN
biomedich-816	173	47	,	,	PUNCT
biomedich-816	173	48	a.	a.	PROPN
biomedich-816	173	49	,	,	PUNCT
biomedich-816	173	50	zhang	zhang	PROPN
biomedich-816	173	51	,	,	PUNCT
biomedich-816	173	52	x.	x.	NOUN
biomedich-816	173	53	,	,	PUNCT
biomedich-816	173	54	goldbach	goldbach	NOUN
biomedich-816	173	55	-	-	PUNCT
biomedich-816	173	56	mansky	mansky	NOUN
biomedich-816	173	57	,	,	PUNCT
biomedich-816	173	58	r.	r.	PROPN
biomedich-816	173	59	,	,	PUNCT
biomedich-816	173	60	&	&	CCONJ
biomedich-816	173	61	zlotogorski	zlotogorski	PROPN
biomedich-816	173	62	,	,	PUNCT
biomedich-816	173	63	a.	a.	NOUN
biomedich-816	173	64	(	(	PUNCT
biomedich-816	173	65	2012	2012	NUM
biomedich-816	173	66	)	)	PUNCT
biomedich-816	173	67	.	.	PUNCT
biomedich-816	174	1	mutations	mutation	NOUN
biomedich-816	174	2	in	in	ADP
biomedich-816	174	3	proteasome	proteasome	NOUN
biomedich-816	174	4	subunit	subunit	NOUN
biomedich-816	174	5	β	β	PROPN
biomedich-816	174	6	type	type	NOUN
biomedich-816	174	7	8	8	NUM
biomedich-816	174	8	cause	cause	NOUN
biomedich-816	174	9	chronic	chronic	ADJ
biomedich-816	174	10	atypical	atypical	ADJ
biomedich-816	174	11	neutrophilic	neutrophilic	ADJ
biomedich-816	174	12	dermatosis	dermatosis	NOUN
biomedich-816	174	13	with	with	ADP
biomedich-816	174	14	lipodystrophy	lipodystrophy	NOUN
biomedich-816	174	15	and	and	CCONJ
biomedich-816	174	16	elevated	elevated	ADJ
biomedich-816	174	17	temperature	temperature	NOUN
biomedich-816	174	18	with	with	ADP
biomedich-816	174	19	evidence	evidence	NOUN
biomedich-816	174	20	of	of	ADP
biomedich-816	174	21	genetic	genetic	ADJ
biomedich-816	174	22	and	and	CCONJ
biomedich-816	174	23	phenotypic	phenotypic	ADJ
biomedich-816	174	24	heterogeneity	heterogeneity	NOUN
biomedich-816	174	25	.	.	PUNCT
biomedich-816	175	1	arthritis	arthritis	NOUN
biomedich-816	175	2	and	and	CCONJ
biomedich-816	175	3	rheumatism	rheumatism	NOUN
biomedich-816	175	4	,	,	PUNCT
biomedich-816	175	5	64(3	64(3	NOUN
biomedich-816	175	6	)	)	PUNCT
biomedich-816	175	7	,	,	PUNCT
biomedich-816	175	8	895–907	895–907	NUM
biomedich-816	175	9	.	.	PUNCT
biomedich-816	176	1	https://doi.org/10.1002/art.33368	https://doi.org/10.1002/art.33368	PROPN
biomedich-816	176	2	ma’ruf	ma’ruf	PROPN
biomedich-816	176	3	,	,	PUNCT
biomedich-816	176	4	m.	m.	NOUN
biomedich-816	176	5	,	,	PUNCT
biomedich-816	176	6	fadli	fadli	PROPN
biomedich-816	176	7	,	,	PUNCT
biomedich-816	176	8	j.	j.	PROPN
biomedich-816	176	9	c.	c.	PROPN
biomedich-816	176	10	,	,	PUNCT
biomedich-816	176	11	mahendra	mahendra	PROPN
biomedich-816	176	12	,	,	PUNCT
biomedich-816	176	13	m.	m.	PROPN
biomedich-816	176	14	r.	r.	PROPN
biomedich-816	176	15	,	,	PUNCT
biomedich-816	176	16	irham	irham	PROPN
biomedich-816	176	17	,	,	PUNCT
biomedich-816	176	18	l.	l.	PROPN
biomedich-816	176	19	m.	m.	PROPN
biomedich-816	176	20	,	,	PUNCT
biomedich-816	176	21	sulistyani	sulistyani	NOUN
biomedich-816	176	22	,	,	PUNCT
biomedich-816	176	23	n.	n.	NOUN
biomedich-816	176	24	,	,	PUNCT
biomedich-816	176	25	adikusuma	adikusuma	PROPN
biomedich-816	176	26	,	,	PUNCT
biomedich-816	176	27	w.	w.	PROPN
biomedich-816	176	28	,	,	PUNCT
biomedich-816	176	29	chong	chong	PROPN
biomedich-816	176	30	,	,	PUNCT
biomedich-816	176	31	r.	r.	PROPN
biomedich-816	176	32	,	,	PUNCT
biomedich-816	176	33	&	&	CCONJ
biomedich-816	176	34	septama	septama	NOUN
biomedich-816	176	35	,	,	PUNCT
biomedich-816	176	36	a.	a.	NOUN
biomedich-816	176	37	w.	w.	PROPN
biomedich-816	176	38	(	(	PUNCT
biomedich-816	176	39	2023	2023	NUM
biomedich-816	176	40	)	)	PUNCT
biomedich-816	176	41	.	.	PUNCT
biomedich-816	177	1	a	a	DET
biomedich-816	177	2	bioinformatic	bioinformatic	ADJ
biomedich-816	177	3	approach	approach	NOUN
biomedich-816	177	4	to	to	PART
biomedich-816	177	5	identify	identify	VERB
biomedich-816	177	6	pathogenic	pathogenic	ADJ
biomedich-816	177	7	variants	variant	NOUN
biomedich-816	177	8	for	for	ADP
biomedich-816	177	9	stevens	stevens	PROPN
biomedich-816	177	10	-	-	PUNCT
biomedich-816	177	11	johnson	johnson	PROPN
biomedich-816	177	12	syndrome	syndrome	NOUN
biomedich-816	177	13	.	.	PUNCT
biomedich-816	178	1	genomics	genomic	NOUN
biomedich-816	178	2	and	and	CCONJ
biomedich-816	178	3	informatics	informatics	PROPN
biomedich-816	178	4	,	,	PUNCT
biomedich-816	178	5	21(2	21(2	NUM
biomedich-816	178	6	)	)	PUNCT
biomedich-816	178	7	.	.	PUNCT
biomedich-816	179	1	https://doi.org/10.5808/gi.23010	https://doi.org/10.5808/gi.23010	PROPN
biomedich-816	179	2	ou	ou	PROPN
biomedich-816	179	3	,	,	PUNCT
biomedich-816	179	4	w.-t	w.-t	NOUN
biomedich-816	179	5	.	.	PUNCT
biomedich-816	179	6	,	,	PUNCT
biomedich-816	179	7	wan	wan	PROPN
biomedich-816	179	8	,	,	PUNCT
biomedich-816	179	9	q.-x	q.-x	PROPN
biomedich-816	179	10	.	.	PROPN
biomedich-816	179	11	,	,	PUNCT
biomedich-816	179	12	wu	wu	PROPN
biomedich-816	179	13	,	,	PUNCT
biomedich-816	179	14	y.-b	y.-b	PROPN
biomedich-816	179	15	.	.	PROPN
biomedich-816	179	16	,	,	PUNCT
biomedich-816	179	17	sun	sun	PROPN
biomedich-816	179	18	,	,	PUNCT
biomedich-816	179	19	x.	x.	PROPN
biomedich-816	179	20	,	,	PUNCT
biomedich-816	179	21	li	li	PROPN
biomedich-816	179	22	,	,	PUNCT
biomedich-816	179	23	y.-l	y.-l	NOUN
biomedich-816	179	24	.	.	PUNCT
biomedich-816	179	25	,	,	PUNCT
biomedich-816	179	26	tang	tang	PROPN
biomedich-816	179	27	,	,	PUNCT
biomedich-816	179	28	d.	d.	PROPN
biomedich-816	179	29	,	,	PUNCT
biomedich-816	179	30	zhang	zhang	PROPN
biomedich-816	179	31	,	,	PUNCT
biomedich-816	179	32	j.	j.	PROPN
biomedich-816	179	33	,	,	PUNCT
biomedich-816	179	34	li	li	PROPN
biomedich-816	179	35	,	,	PUNCT
biomedich-816	179	36	s.-s	s.-	NOUN
biomedich-816	179	37	.	.	PUNCT
biomedich-816	179	38	,	,	PUNCT
biomedich-816	179	39	wang	wang	PROPN
biomedich-816	179	40	,	,	PUNCT
biomedich-816	179	41	n.-y	n.-y	NOUN
biomedich-816	179	42	.	.	PUNCT
biomedich-816	179	43	,	,	PUNCT
biomedich-816	179	44	liu	liu	PROPN
biomedich-816	179	45	,	,	PUNCT
biomedich-816	179	46	z.-l	z.-l	PROPN
biomedich-816	179	47	.	.	PUNCT
biomedich-816	179	48	,	,	PUNCT
biomedich-816	179	49	&	&	CCONJ
biomedich-816	179	50	wu	wu	PROPN
biomedich-816	179	51	,	,	PUNCT
biomedich-816	179	52	j.-j	j.-j	PROPN
biomedich-816	179	53	.	.	PUNCT
biomedich-816	180	1	(	(	PUNCT
biomedich-816	180	2	2024	2024	NUM
biomedich-816	180	3	)	)	PUNCT
biomedich-816	180	4	.	.	PUNCT
biomedich-816	181	1	long	long	ADJ
biomedich-816	181	2	noncoding	noncode	VERB
biomedich-816	181	3	rna	rna	NOUN
biomedich-816	181	4	psmb8	psmb8	PROPN
biomedich-816	181	5	-	-	PUNCT
biomedich-816	181	6	as1	as1	NOUN
biomedich-816	181	7	mediates	mediate	NOUN
biomedich-816	181	8	the	the	DET
biomedich-816	181	9	tobacco	tobacco	NOUN
biomedich-816	181	10	-	-	PUNCT
biomedich-816	181	11	carcinogen	carcinogen	NOUN
biomedich-816	181	12	-	-	PUNCT
biomedich-816	181	13	induced	induce	VERB
biomedich-816	181	14	transformation	transformation	NOUN
biomedich-816	181	15	of	of	ADP
biomedich-816	181	16	a	a	DET
biomedich-816	181	17	human	human	ADJ
biomedich-816	181	18	bronchial	bronchial	ADJ
biomedich-816	181	19	epithelial	epithelial	ADJ
biomedich-816	181	20	cell	cell	NOUN
biomedich-816	181	21	line	line	NOUN
biomedich-816	181	22	by	by	ADP
biomedich-816	181	23	regulating	regulate	VERB
biomedich-816	181	24	cell	cell	NOUN
biomedich-816	181	25	cycle	cycle	NOUN
biomedich-816	181	26	.	.	PUNCT
biomedich-816	182	1	chemical	chemical	ADJ
biomedich-816	182	2	research	research	NOUN
biomedich-816	182	3	in	in	ADP
biomedich-816	182	4	toxicology	toxicology	NOUN
biomedich-816	182	5	,	,	PUNCT
biomedich-816	182	6	37(6	37(6	NUM
biomedich-816	182	7	)	)	PUNCT
biomedich-816	182	8	,	,	PUNCT
biomedich-816	182	9	957–967	957–967	NUM
biomedich-816	182	10	.	.	PUNCT
biomedich-816	183	1	https://doi.org/10.1021/acs.chemrestox.4c00025	https://doi.org/10.1021/acs.chemrestox.4c00025	PROPN
biomedich-816	183	2	pendergrass	pendergrass	PROPN
biomedich-816	183	3	,	,	PUNCT
biomedich-816	183	4	s.	s.	PROPN
biomedich-816	183	5	a.	a.	PROPN
biomedich-816	183	6	,	,	PUNCT
biomedich-816	183	7	dudek	dudek	PROPN
biomedich-816	183	8	,	,	PUNCT
biomedich-816	183	9	s.	s.	PROPN
biomedich-816	183	10	m.	m.	PROPN
biomedich-816	183	11	,	,	PUNCT
biomedich-816	183	12	crawford	crawford	PROPN
biomedich-816	183	13	,	,	PUNCT
biomedich-816	183	14	d.	d.	PROPN
biomedich-816	183	15	c.	c.	PROPN
biomedich-816	183	16	,	,	PUNCT
biomedich-816	183	17	&	&	CCONJ
biomedich-816	183	18	ritchie	ritchie	PROPN
biomedich-816	183	19	,	,	PUNCT
biomedich-816	183	20	m.	m.	PROPN
biomedich-816	183	21	d.	d.	PROPN
biomedich-816	183	22	(	(	PUNCT
biomedich-816	183	23	2012	2012	NUM
biomedich-816	183	24	)	)	PUNCT
biomedich-816	183	25	.	.	PUNCT
biomedich-816	184	1	visually	visually	ADV
biomedich-816	184	2	integrating	integrate	VERB
biomedich-816	184	3	and	and	CCONJ
biomedich-816	184	4	exploring	explore	VERB
biomedich-816	184	5	high	high	ADJ
biomedich-816	184	6	throughput	throughput	NOUN
biomedich-816	184	7	phenome	phenome	ADV
biomedich-816	184	8	-	-	PUNCT
biomedich-816	184	9	wide	wide	ADJ
biomedich-816	184	10	association	association	NOUN
biomedich-816	184	11	study	study	NOUN
biomedich-816	184	12	(	(	PUNCT
biomedich-816	184	13	phewas	phewas	PROPN
biomedich-816	184	14	)	)	PUNCT
biomedich-816	184	15	results	result	NOUN
biomedich-816	184	16	using	use	VERB
biomedich-816	184	17	phewas	phewas	NOUN
biomedich-816	184	18	-	-	PUNCT
biomedich-816	184	19	view	view	NOUN
biomedich-816	184	20	.	.	PUNCT
biomedich-816	185	1	biodata	biodata	PROPN
biomedich-816	185	2	mining	mining	PROPN
biomedich-816	185	3	,	,	PUNCT
biomedich-816	185	4	5(1	5(1	NUM
biomedich-816	185	5	)	)	PUNCT
biomedich-816	185	6	.	.	PUNCT
biomedich-816	186	1	https://doi.org/10.1186/1756-0381-5-5	https://doi.org/10.1186/1756-0381-5-5	NOUN
biomedich-816	186	2	poole	poole	PROPN
biomedich-816	186	3	,	,	PUNCT
biomedich-816	186	4	j.	j.	PROPN
biomedich-816	186	5	a.	a.	PROPN
biomedich-816	186	6	,	,	PUNCT
biomedich-816	186	7	zamora	zamora	PROPN
biomedich-816	186	8	-	-	PUNCT
biomedich-816	186	9	sifuentes	sifuentes	PROPN
biomedich-816	186	10	,	,	PUNCT
biomedich-816	186	11	j.	j.	PROPN
biomedich-816	186	12	l.	l.	PROPN
biomedich-816	186	13	,	,	PUNCT
biomedich-816	186	14	de	de	PROPN
biomedich-816	186	15	las	las	PROPN
biomedich-816	186	16	vecillas	vecillas	PROPN
biomedich-816	186	17	,	,	PUNCT
biomedich-816	186	18	l.	l.	PROPN
biomedich-816	186	19	,	,	PUNCT
biomedich-816	186	20	&	&	CCONJ
biomedich-816	186	21	quirce	quirce	PROPN
biomedich-816	186	22	,	,	PUNCT
biomedich-816	186	23	s.	s.	PROPN
biomedich-816	186	24	(	(	PUNCT
biomedich-816	186	25	2024	2024	NUM
biomedich-816	186	26	)	)	PUNCT
biomedich-816	186	27	.	.	PUNCT
biomedich-816	187	1	respiratory	respiratory	ADJ
biomedich-816	187	2	diseases	disease	NOUN
biomedich-816	187	3	associated	associate	VERB
biomedich-816	187	4	with	with	ADP
biomedich-816	187	5	organic	organic	ADJ
biomedich-816	187	6	dust	dust	NOUN
biomedich-816	187	7	exposure	exposure	NOUN
biomedich-816	187	8	.	.	PUNCT
biomedich-816	188	1	journal	journal	PROPN
biomedich-816	188	2	of	of	ADP
biomedich-816	188	3	allergy	allergy	NOUN
biomedich-816	188	4	and	and	CCONJ
biomedich-816	188	5	clinical	clinical	ADJ
biomedich-816	188	6	immunology	immunology	NOUN
biomedich-816	188	7	:	:	PUNCT
biomedich-816	188	8	in	in	ADP
biomedich-816	188	9	practice	practice	NOUN
biomedich-816	188	10	,	,	PUNCT
biomedich-816	188	11	12(8	12(8	NUM
biomedich-816	188	12	)	)	PUNCT
biomedich-816	188	13	,	,	PUNCT
biomedich-816	188	14	1960–1971	1960–1971	NUM
biomedich-816	188	15	.	.	PUNCT
biomedich-816	189	1	https://doi.org/10.1016/j.jaip.2024.02.022	https://doi.org/10.1016/j.jaip.2024.02.022	PROPN
biomedich-816	189	2	qureshi	qureshi	PROPN
biomedich-816	189	3	,	,	PUNCT
biomedich-816	189	4	r.	r.	PROPN
biomedich-816	189	5	(	(	PUNCT
biomedich-816	189	6	2020	2020	NUM
biomedich-816	189	7	)	)	PUNCT
biomedich-816	189	8	.	.	PUNCT
biomedich-816	190	1	personalized	personalize	VERB
biomedich-816	190	2	drug	drug	NOUN
biomedich-816	190	3	-	-	PUNCT
biomedich-816	190	4	response	response	NOUN
biomedich-816	190	5	prediction	prediction	NOUN
biomedich-816	190	6	model	model	NOUN
biomedich-816	190	7	for	for	ADP
biomedich-816	190	8	lung	lung	NOUN
biomedich-816	190	9	cancer	cancer	NOUN
biomedich-816	190	10	patients	patient	NOUN
biomedich-816	190	11	using	use	VERB
biomedich-816	190	12	machine	machine	NOUN
biomedich-816	190	13	learning	learn	VERB
biomedich-816	190	14	personalized	personalize	VERB
biomedich-816	190	15	drug	drug	NOUN
biomedich-816	190	16	-	-	PUNCT
biomedich-816	190	17	response	response	NOUN
biomedich-816	190	18	prediction	prediction	NOUN
biomedich-816	190	19	model	model	NOUN
biomedich-816	190	20	for	for	ADP
biomedich-816	190	21	lung	lung	NOUN
biomedich-816	190	22	cancer	cancer	NOUN
biomedich-816	190	23	personalized	personalize	VERB
biomedich-816	190	24	drug	drug	NOUN
biomedich-816	190	25	-	-	PUNCT
biomedich-816	190	26	response	response	NOUN
biomedich-816	190	27	prediction	prediction	NOUN
biomedich-816	190	28	model	model	NOUN
biomedich-816	190	29	for	for	ADP
biomedich-816	190	30	lung	lung	NOUN
biomedich-816	190	31	cancer	cancer	NOUN
biomedich-816	190	32	patients	patient	NOUN
biomedich-816	190	33	using	use	VERB
biomedich-816	190	34	machine	machine	NOUN
biomedich-816	190	35	learning	learn	VERB
biomedich-816	190	36	patients	patient	NOUN
biomedich-816	190	37	using	use	VERB
biomedich-816	190	38	machine	machine	NOUN
biomedich-816	190	39	learning	learning	NOUN
biomedich-816	190	40	.	.	PUNCT
biomedich-816	191	1	techrxiv	techrxiv	PROPN
biomedich-816	191	2	.	.	PUNCT
biomedich-816	192	1	https://doi.org/10.36227/techrxiv.13273319.v1	https://doi.org/10.36227/techrxiv.13273319.v1	PROPN
biomedich-816	192	2	santri	santri	PROPN
biomedich-816	192	3	,	,	PUNCT
biomedich-816	192	4	i.	i.	PROPN
biomedich-816	192	5	n.	n.	PROPN
biomedich-816	192	6	,	,	PUNCT
biomedich-816	192	7	irham	irham	PROPN
biomedich-816	192	8	,	,	PUNCT
biomedich-816	192	9	l.	l.	PROPN
biomedich-816	192	10	m.	m.	PROPN
biomedich-816	192	11	,	,	PUNCT
biomedich-816	192	12	djalilah	djalilah	PROPN
biomedich-816	192	13	,	,	PUNCT
biomedich-816	192	14	g.	g.	PROPN
biomedich-816	192	15	n.	n.	PROPN
biomedich-816	192	16	,	,	PUNCT
biomedich-816	192	17	perwitasari	perwitasari	PROPN
biomedich-816	192	18	,	,	PUNCT
biomedich-816	192	19	d.	d.	PROPN
biomedich-816	192	20	a.	a.	PROPN
biomedich-816	192	21	,	,	PUNCT
biomedich-816	192	22	wardani	wardani	PROPN
biomedich-816	192	23	,	,	PUNCT
biomedich-816	192	24	y.	y.	PROPN
biomedich-816	192	25	,	,	PUNCT
biomedich-816	192	26	phiri	phiri	PROPN
biomedich-816	192	27	,	,	PUNCT
biomedich-816	193	1	y.	y.	PROPN
biomedich-816	193	2	v.	v.	PROPN
biomedich-816	193	3	a.	a.	PROPN
biomedich-816	193	4	,	,	PUNCT
biomedich-816	193	5	&	&	CCONJ
biomedich-816	193	6	adikusuma	adikusuma	PROPN
biomedich-816	193	7	,	,	PUNCT
biomedich-816	193	8	w.	w.	PROPN
biomedich-816	193	9	(	(	PUNCT
biomedich-816	193	10	2022	2022	NUM
biomedich-816	193	11	)	)	PUNCT
biomedich-816	193	12	.	.	PUNCT
biomedich-816	194	1	identification	identification	NOUN
biomedich-816	194	2	of	of	ADP
biomedich-816	194	3	hub	hub	NOUN
biomedich-816	194	4	genes	gene	NOUN
biomedich-816	194	5	and	and	CCONJ
biomedich-816	194	6	potential	potential	ADJ
biomedich-816	194	7	biomarkers	biomarker	NOUN
biomedich-816	194	8	for	for	ADP
biomedich-816	194	9	childhood	childhood	NOUN
biomedich-816	194	10	asthma	asthma	NOUN
biomedich-816	194	11	by	by	ADP
biomedich-816	194	12	utilizing	utilize	VERB
biomedich-816	194	13	an	an	DET
biomedich-816	194	14	established	establish	VERB
biomedich-816	194	15	bioinformatic	bioinformatic	ADJ
biomedich-816	194	16	analysis	analysis	NOUN
biomedich-816	194	17	approach	approach	NOUN
biomedich-816	194	18	.	.	PUNCT
biomedich-816	195	1	biomedicines	biomedicine	NOUN
biomedich-816	195	2	,	,	PUNCT
biomedich-816	195	3	10(9	10(9	NUM
biomedich-816	195	4	)	)	PUNCT
biomedich-816	195	5	.	.	PUNCT
biomedich-816	196	1	https://doi.org/10.3390/biomedicines10092311	https://doi.org/10.3390/biomedicines10092311	PROPN
biomedich-816	196	2	shamilov	shamilov	PROPN
biomedich-816	196	3	,	,	PUNCT
biomedich-816	196	4	r.	r.	PROPN
biomedich-816	196	5	,	,	PUNCT
biomedich-816	196	6	&	&	CCONJ
biomedich-816	196	7	aneskievich	aneskievich	PROPN
biomedich-816	196	8	,	,	PUNCT
biomedich-816	196	9	b.	b.	PROPN
biomedich-816	196	10	j.	j.	PROPN
biomedich-816	196	11	(	(	PUNCT
biomedich-816	196	12	2018	2018	NUM
biomedich-816	196	13	)	)	PUNCT
biomedich-816	196	14	.	.	PUNCT
biomedich-816	197	1	tnip1	tnip1	ADJ
biomedich-816	197	2	in	in	ADP
biomedich-816	197	3	autoimmune	autoimmune	ADJ
biomedich-816	197	4	diseases	disease	NOUN
biomedich-816	197	5	:	:	PUNCT
biomedich-816	197	6	regulation	regulation	NOUN
biomedich-816	197	7	of	of	ADP
biomedich-816	197	8	toll	toll	NOUN
biomedich-816	197	9	-	-	PUNCT
biomedich-816	197	10	like	like	ADJ
biomedich-816	197	11	receptor	receptor	NOUN
biomedich-816	197	12	signaling	signal	VERB
biomedich-816	197	13	.	.	PUNCT
biomedich-816	198	1	journal	journal	NOUN
biomedich-816	198	2	of	of	ADP
biomedich-816	198	3	immunology	immunology	NOUN
biomedich-816	198	4	research	research	NOUN
biomedich-816	198	5	,	,	PUNCT
biomedich-816	198	6	2018	2018	NUM
biomedich-816	198	7	.	.	PUNCT
biomedich-816	199	1	https://doi.org/10.1155/2018/3491269	https://doi.org/10.1155/2018/3491269	PROPN
biomedich-816	199	2	tripathi	tripathi	PROPN
biomedich-816	199	3	,	,	PUNCT
biomedich-816	199	4	s.	s.	PROPN
biomedich-816	199	5	c.	c.	PROPN
biomedich-816	199	6	,	,	PUNCT
biomedich-816	199	7	peters	peters	PROPN
biomedich-816	199	8	,	,	PUNCT
biomedich-816	199	9	h.	h.	PROPN
biomedich-816	199	10	l.	l.	PROPN
biomedich-816	199	11	,	,	PUNCT
biomedich-816	199	12	taguchi	taguchi	PROPN
biomedich-816	199	13	,	,	PUNCT
biomedich-816	199	14	a.	a.	PROPN
biomedich-816	199	15	,	,	PUNCT
biomedich-816	199	16	katayama	katayama	PROPN
biomedich-816	199	17	,	,	PUNCT
biomedich-816	199	18	h.	h.	PROPN
biomedich-816	199	19	,	,	PUNCT
biomedich-816	199	20	wang	wang	PROPN
biomedich-816	199	21	,	,	PUNCT
biomedich-816	199	22	h.	h.	PROPN
biomedich-816	199	23	,	,	PUNCT
biomedich-816	199	24	momin	momin	PROPN
biomedich-816	199	25	,	,	PUNCT
biomedich-816	199	26	a.	a.	NOUN
biomedich-816	199	27	,	,	PUNCT
biomedich-816	199	28	jolly	jolly	ADV
biomedich-816	199	29	,	,	PUNCT
biomedich-816	199	30	m.	m.	PROPN
biomedich-816	199	31	k.	k.	PROPN
biomedich-816	199	32	,	,	PUNCT
biomedich-816	199	33	celiktas	celikta	NOUN
biomedich-816	199	34	,	,	PUNCT
biomedich-816	199	35	m.	m.	NOUN
biomedich-816	199	36	,	,	PUNCT
biomedich-816	199	37	rodriguez	rodriguez	NOUN
biomedich-816	199	38	-	-	PUNCT
biomedich-816	199	39	canales	canale	NOUN
biomedich-816	199	40	,	,	PUNCT
biomedich-816	199	41	j.	j.	PROPN
biomedich-816	199	42	,	,	PUNCT
biomedich-816	199	43	liu	liu	PROPN
biomedich-816	199	44	,	,	PUNCT
biomedich-816	199	45	h.	h.	PROPN
biomedich-816	199	46	,	,	PUNCT
biomedich-816	199	47	behrens	behrens	PROPN
biomedich-816	199	48	,	,	PUNCT
biomedich-816	199	49	c.	c.	PROPN
biomedich-816	199	50	,	,	PUNCT
biomedich-816	199	51	wistuba	wistuba	PROPN
biomedich-816	199	52	,	,	PUNCT
biomedich-816	199	53	i.	i.	PROPN
biomedich-816	199	54	i.	i.	PROPN
biomedich-816	199	55	,	,	PUNCT
biomedich-816	199	56	ben	ben	PROPN
biomedich-816	199	57	-	-	PUNCT
biomedich-816	199	58	jacob	jacob	PROPN
biomedich-816	199	59	,	,	PUNCT
biomedich-816	199	60	e.	e.	PROPN
biomedich-816	199	61	,	,	PUNCT
biomedich-816	199	62	levine	levine	PROPN
biomedich-816	199	63	,	,	PUNCT
biomedich-816	199	64	h.	h.	PROPN
biomedich-816	199	65	,	,	PUNCT
biomedich-816	199	66	molldrem	molldrem	PROPN
biomedich-816	199	67	,	,	PUNCT
biomedich-816	199	68	j.	j.	PROPN
biomedich-816	199	69	j.	j.	PROPN
biomedich-816	199	70	,	,	PUNCT
biomedich-816	199	71	hanash	hanash	PROPN
biomedich-816	199	72	,	,	PUNCT
biomedich-816	199	73	s.	s.	PROPN
biomedich-816	199	74	m.	m.	PROPN
biomedich-816	199	75	,	,	PUNCT
biomedich-816	199	76	&	&	CCONJ
biomedich-816	199	77	ostrin	ostrin	NOUN
biomedich-816	199	78	,	,	PUNCT
biomedich-816	199	79	e.	e.	PROPN
biomedich-816	199	80	j.	j.	PROPN
biomedich-816	199	81	(	(	PUNCT
biomedich-816	199	82	2016	2016	NUM
biomedich-816	199	83	)	)	PUNCT
biomedich-816	199	84	.	.	PUNCT
biomedich-816	200	1	immunoproteasome	immunoproteasome	NOUN
biomedich-816	200	2	deficiency	deficiency	NOUN
biomedich-816	200	3	is	be	AUX
biomedich-816	200	4	a	a	DET
biomedich-816	200	5	feature	feature	NOUN
biomedich-816	200	6	of	of	ADP
biomedich-816	200	7	non	non	ADJ
biomedich-816	200	8	-	-	ADJ
biomedich-816	200	9	small	small	ADJ
biomedich-816	200	10	cell	cell	NOUN
biomedich-816	200	11	lung	lung	NOUN
biomedich-816	200	12	cancer	cancer	NOUN
biomedich-816	200	13	with	with	ADP
biomedich-816	200	14	a	a	DET
biomedich-816	200	15	mesenchymal	mesenchymal	ADJ
biomedich-816	200	16	phenotype	phenotype	NOUN
biomedich-816	200	17	and	and	CCONJ
biomedich-816	200	18	is	be	AUX
biomedich-816	200	19	associated	associate	VERB
biomedich-816	200	20	with	with	ADP
biomedich-816	200	21	a	a	DET
biomedich-816	200	22	poor	poor	ADJ
biomedich-816	200	23	outcome	outcome	NOUN
biomedich-816	200	24	.	.	PUNCT
biomedich-816	201	1	proceedings	proceeding	NOUN
biomedich-816	201	2	of	of	ADP
biomedich-816	201	3	the	the	DET
biomedich-816	201	4	national	national	PROPN
biomedich-816	201	5	academy	academy	PROPN
biomedich-816	201	6	of	of	ADP
biomedich-816	201	7	sciences	sciences	PROPN
biomedich-816	201	8	of	of	ADP
biomedich-816	201	9	the	the	DET
biomedich-816	201	10	united	united	PROPN
biomedich-816	201	11	states	states	PROPN
biomedich-816	201	12	of	of	ADP
biomedich-816	201	13	america	america	PROPN
biomedich-816	201	14	,	,	PUNCT
biomedich-816	201	15	113(11	113(11	NUM
biomedich-816	201	16	)	)	PUNCT
biomedich-816	201	17	,	,	PUNCT
biomedich-816	201	18	e1555	e1555	NOUN
biomedich-816	201	19	–	–	PUNCT
biomedich-816	201	20	e1564	e1564	NUM
biomedich-816	201	21	.	.	PROPN
biomedich-816	201	22	https://doi.org/10.1073/pnas.1521812113	https://doi.org/10.1073/pnas.1521812113	PROPN
biomedich-816	201	23	valavanidis	valavanidis	PROPN
biomedich-816	201	24	,	,	PUNCT
biomedich-816	201	25	a.	a.	NOUN
biomedich-816	201	26	,	,	PUNCT
biomedich-816	201	27	vlachogianni	vlachogianni	NOUN
biomedich-816	201	28	,	,	PUNCT
biomedich-816	201	29	t.	t.	PROPN
biomedich-816	201	30	,	,	PUNCT
biomedich-816	201	31	&	&	CCONJ
biomedich-816	201	32	fiotakis	fiotakis	PROPN
biomedich-816	201	33	,	,	PUNCT
biomedich-816	201	34	k.	k.	PROPN
biomedich-816	201	35	(	(	PUNCT
biomedich-816	201	36	2009	2009	NUM
biomedich-816	201	37	)	)	PUNCT
biomedich-816	201	38	.	.	PUNCT
biomedich-816	202	1	tobacco	tobacco	NOUN
biomedich-816	202	2	smoke	smoke	NOUN
biomedich-816	202	3	:	:	PUNCT
biomedich-816	202	4	involvement	involvement	NOUN
biomedich-816	202	5	of	of	ADP
biomedich-816	202	6	reactive	reactive	ADJ
biomedich-816	202	7	oxygen	oxygen	NOUN
biomedich-816	202	8	species	specie	NOUN
biomedich-816	202	9	and	and	CCONJ
biomedich-816	202	10	stable	stable	ADJ
biomedich-816	202	11	free	free	ADJ
biomedich-816	202	12	radicals	radical	NOUN
biomedich-816	202	13	in	in	ADP
biomedich-816	202	14	mechanisms	mechanism	NOUN
biomedich-816	202	15	of	of	ADP
biomedich-816	202	16	oxidative	oxidative	ADJ
biomedich-816	202	17	damage	damage	NOUN
biomedich-816	202	18	,	,	PUNCT
biomedich-816	202	19	carcinogenesis	carcinogenesis	NOUN
biomedich-816	202	20	and	and	CCONJ
biomedich-816	202	21	synergistic	synergistic	ADJ
biomedich-816	202	22	effects	effect	NOUN
biomedich-816	202	23	with	with	ADP
biomedich-816	202	24	other	other	ADJ
biomedich-816	202	25	respirable	respirable	ADJ
biomedich-816	202	26	particles	particle	NOUN
biomedich-816	202	27	.	.	PUNCT
biomedich-816	203	1	international	international	ADJ
biomedich-816	203	2	journal	journal	PROPN
biomedich-816	203	3	of	of	ADP
biomedich-816	203	4	environmental	environmental	ADJ
biomedich-816	203	5	research	research	NOUN
biomedich-816	203	6	and	and	CCONJ
biomedich-816	203	7	public	public	ADJ
biomedich-816	203	8	health	health	NOUN
biomedich-816	203	9	,	,	PUNCT
biomedich-816	203	10	6(2	6(2	NUM
biomedich-816	203	11	)	)	PUNCT
biomedich-816	203	12	,	,	PUNCT
biomedich-816	204	1	445–462	445–462	NUM
biomedich-816	204	2	.	.	PUNCT
biomedich-816	205	1	https://doi.org/10.3390/ijerph6020445	https://doi.org/10.3390/ijerph6020445	NOUN
biomedich-816	205	2	victoni	victoni	PROPN
biomedich-816	205	3	,	,	PUNCT
biomedich-816	205	4	t.	t.	PROPN
biomedich-816	205	5	,	,	PUNCT
biomedich-816	205	6	barreto	barreto	PROPN
biomedich-816	205	7	,	,	PUNCT
biomedich-816	205	8	e.	e.	PROPN
biomedich-816	205	9	,	,	PUNCT
biomedich-816	205	10	lagente	lagente	PROPN
biomedich-816	205	11	,	,	PUNCT
biomedich-816	205	12	v.	v.	PROPN
biomedich-816	205	13	,	,	PUNCT
biomedich-816	205	14	&	&	CCONJ
biomedich-816	205	15	carvalho	carvalho	PROPN
biomedich-816	205	16	,	,	PUNCT
biomedich-816	205	17	v.	v.	PROPN
biomedich-816	205	18	f.	f.	PROPN
biomedich-816	205	19	(	(	PUNCT
biomedich-816	205	20	2021	2021	NUM
biomedich-816	205	21	)	)	PUNCT
biomedich-816	205	22	.	.	PUNCT
biomedich-816	206	1	oxidative	oxidative	ADJ
biomedich-816	206	2	imbalance	imbalance	NOUN
biomedich-816	206	3	as	as	ADP
biomedich-816	206	4	a	a	DET
biomedich-816	206	5	crucial	crucial	ADJ
biomedich-816	206	6	factor	factor	NOUN
biomedich-816	206	7	in	in	ADP
biomedich-816	206	8	inflammatory	inflammatory	ADJ
biomedich-816	206	9	lung	lung	NOUN
biomedich-816	206	10	diseases	disease	NOUN
biomedich-816	206	11	:	:	PUNCT
biomedich-816	206	12	could	could	AUX
biomedich-816	206	13	antioxidant	antioxidant	VERB
biomedich-816	206	14	treatment	treatment	NOUN
biomedich-816	206	15	constitute	constitute	VERB
biomedich-816	206	16	a	a	DET
biomedich-816	206	17	new	new	ADJ
biomedich-816	206	18	therapeutic	therapeutic	ADJ
biomedich-816	206	19	strategy	strategy	NOUN
biomedich-816	206	20	?	?	PUNCT
biomedich-816	207	1	in	in	ADP
biomedich-816	207	2	oxidative	oxidative	ADJ
biomedich-816	207	3	medicine	medicine	NOUN
biomedich-816	207	4	and	and	CCONJ
biomedich-816	207	5	cellular	cellular	ADJ
biomedich-816	207	6	longevity	longevity	NOUN
biomedich-816	207	7	(	(	PUNCT
biomedich-816	207	8	vol	vol	NOUN
biomedich-816	207	9	.	.	NOUN
biomedich-816	207	10	2021	2021	NUM
biomedich-816	207	11	)	)	PUNCT
biomedich-816	207	12	.	.	PUNCT
biomedich-816	208	1	hindawi	hindawi	PROPN
biomedich-816	208	2	limited	limited	ADJ
biomedich-816	208	3	.	.	PUNCT
biomedich-816	209	1	https://doi.org/10.1155/2021/6646923	https://doi.org/10.1155/2021/6646923	PROPN
biomedich-816	210	1	xie	xie	PROPN
biomedich-816	210	2	,	,	PUNCT
biomedich-816	210	3	t.	t.	PROPN
biomedich-816	210	4	,	,	PUNCT
biomedich-816	210	5	guangyu	guangyu	NOUN
biomedich-816	210	6	,	,	PUNCT
biomedich-816	210	7	f.	f.	PROPN
biomedich-816	210	8	,	,	PUNCT
biomedich-816	210	9	liling	liling	NOUN
biomedich-816	210	10	,	,	PUNCT
biomedich-816	210	11	h.	h.	PROPN
biomedich-816	210	12	,	,	PUNCT
biomedich-816	210	13	ning	ning	PROPN
biomedich-816	210	14	,	,	PUNCT
biomedich-816	210	15	l.	l.	PROPN
biomedich-816	210	16	,	,	PUNCT
biomedich-816	210	17	xiaohong	xiaohong	PROPN
biomedich-816	210	18	,	,	PUNCT
biomedich-816	210	19	h.	h.	PROPN
biomedich-816	210	20	,	,	PUNCT
biomedich-816	210	21	puyuan	puyuan	PROPN
biomedich-816	210	22	,	,	PUNCT
biomedich-816	210	23	x.	x.	NOUN
biomedich-816	210	24	,	,	PUNCT
biomedich-816	210	25	&	&	CCONJ
biomedich-816	210	26	and	and	CCONJ
biomedich-816	210	27	shi	shi	PROPN
biomedich-816	210	28	,	,	PUNCT
biomedich-816	210	29	y.	y.	PROPN
biomedich-816	210	30	(	(	PUNCT
biomedich-816	210	31	2022	2022	NUM
biomedich-816	210	32	)	)	PUNCT
biomedich-816	210	33	.	.	PUNCT
biomedich-816	211	1	analysis	analysis	NOUN
biomedich-816	211	2	on	on	ADP
biomedich-816	211	3	methylation	methylation	NOUN
biomedich-816	211	4	and	and	CCONJ
biomedich-816	211	5	expression	expression	NOUN
biomedich-816	211	6	of	of	ADP
biomedich-816	211	7	psmb8	psmb8	NOUN
biomedich-816	211	8	and	and	CCONJ
biomedich-816	211	9	its	its	PRON
biomedich-816	211	10	correlation	correlation	NOUN
biomedich-816	211	11	with	with	ADP
biomedich-816	211	12	immunity	immunity	NOUN
biomedich-816	211	13	and	and	CCONJ
biomedich-816	211	14	immunotherapy	immunotherapy	NOUN
biomedich-816	211	15	in	in	ADP
biomedich-816	211	16	lung	lung	NOUN
biomedich-816	211	17	adenocarcinoma	adenocarcinoma	NOUN
biomedich-816	211	18	.	.	PUNCT
biomedich-816	212	1	epigenomics	epigenomic	NOUN
biomedich-816	212	2	,	,	PUNCT
biomedich-816	212	3	14(22	14(22	NUM
biomedich-816	212	4	)	)	PUNCT
biomedich-816	212	5	,	,	PUNCT
biomedich-816	212	6	1427–1448	1427–1448	NUM
biomedich-816	212	7	.	.	PUNCT
biomedich-816	212	8	https://doi.org/10.2217/epi-2022-0282	https://doi.org/10.2217/epi-2022-0282	NOUN
biomedich-816	212	9	this	this	DET
biomedich-816	212	10	page	page	NOUN
biomedich-816	212	11	intentionally	intentionally	ADV
biomedich-816	212	12	left	leave	VERB
biomedich-816	212	13	blank	blank	ADV