id	sid	tid	token	lemma	pos
biomedich-819	1	1	biology	biology	NOUN
biomedich-819	1	2	,	,	PUNCT
biomedich-819	1	3	medicine	medicine	NOUN
biomedich-819	1	4	,	,	PUNCT
biomedich-819	1	5	&	&	CCONJ
biomedich-819	1	6	natural	natural	ADJ
biomedich-819	1	7	product	product	NOUN
biomedich-819	1	8	chemistry	chemistry	NOUN
biomedich-819	1	9	issn	issn	VERB
biomedich-819	1	10	2089	2089	NUM
biomedich-819	1	11	-	-	SYM
biomedich-819	1	12	6514	6514	NUM
biomedich-819	1	13	(	(	PUNCT
biomedich-819	1	14	paper	paper	NOUN
biomedich-819	1	15	)	)	PUNCT
biomedich-819	1	16	volume	volume	NOUN
biomedich-819	1	17	14	14	NUM
biomedich-819	1	18	,	,	PUNCT
biomedich-819	1	19	number	number	NOUN
biomedich-819	1	20	2	2	NUM
biomedich-819	1	21	,	,	PUNCT
biomedich-819	1	22	october	october	PROPN
biomedich-819	1	23	2025	2025	NUM
biomedich-819	1	24	|	|	ADV
biomedich-819	1	25	pages	page	NOUN
biomedich-819	1	26	:	:	PUNCT
biomedich-819	1	27	921	921	NUM
biomedich-819	1	28	-	-	SYM
biomedich-819	1	29	926	926	NUM
biomedich-819	1	30	|	|	ADV
biomedich-819	1	31	doi	doi	NOUN
biomedich-819	1	32	:	:	PUNCT
biomedich-819	1	33	10.14421	10.14421	NUM
biomedich-819	1	34	/	/	SYM
biomedich-819	1	35	biomedich.2025.142.921	biomedich.2025.142.921	NOUN
biomedich-819	1	36	-	-	PUNCT
biomedich-819	1	37	926	926	NUM
biomedich-819	1	38	issn	issn	PROPN
biomedich-819	1	39	2540	2540	NUM
biomedich-819	1	40	-	-	SYM
biomedich-819	1	41	9328	9328	NUM
biomedich-819	1	42	(	(	PUNCT
biomedich-819	1	43	online	online	ADJ
biomedich-819	1	44	)	)	PUNCT
biomedich-819	1	45	sirnas	sirna	NOUN
biomedich-819	1	46	targeting	target	VERB
biomedich-819	1	47	icad	icad	ADJ
biomedich-819	1	48	gene	gene	NOUN
biomedich-819	1	49	of	of	ADP
biomedich-819	1	50	staphylococcus	staphylococcus	NOUN
biomedich-819	1	51	aureus	aureus	NOUN
biomedich-819	1	52	to	to	PART
biomedich-819	1	53	inhibit	inhibit	VERB
biomedich-819	1	54	biofilm	biofilm	NOUN
biomedich-819	1	55	formation	formation	NOUN
biomedich-819	1	56	:	:	PUNCT
biomedich-819	1	57	structural	structural	ADJ
biomedich-819	1	58	analysis	analysis	NOUN
biomedich-819	1	59	and	and	CCONJ
biomedich-819	1	60	efficacy	efficacy	NOUN
biomedich-819	1	61	dinda	dinda	PROPN
biomedich-819	1	62	ananda	ananda	PROPN
biomedich-819	1	63	sulistina1	sulistina1	PROPN
biomedich-819	1	64	,	,	PUNCT
biomedich-819	1	65	rian	rian	PROPN
biomedich-819	1	66	ka	ka	PROPN
biomedich-819	1	67	praja2	praja2	PROPN
biomedich-819	1	68	*	*	PROPN
biomedich-819	1	69	,	,	PUNCT
biomedich-819	1	70	margaretha	margaretha	X
biomedich-819	1	71	yayu	yayu	PROPN
biomedich-819	1	72	indah	indah	PROPN
biomedich-819	1	73	anugerahny3	anugerahny3	PROPN
biomedich-819	1	74	,	,	PUNCT
biomedich-819	1	75	hanasia2	hanasia2	PROPN
biomedich-819	1	76	,	,	PUNCT
biomedich-819	1	77	ysrafil4	ysrafil4	ADJ
biomedich-819	1	78	1undergraduate	1undergraduate	NUM
biomedich-819	1	79	program	program	NOUN
biomedich-819	1	80	of	of	ADP
biomedich-819	1	81	medicine	medicine	NOUN
biomedich-819	1	82	,	,	PUNCT
biomedich-819	1	83	faculty	faculty	NOUN
biomedich-819	1	84	of	of	ADP
biomedich-819	1	85	medicine	medicine	NOUN
biomedich-819	1	86	,	,	PUNCT
biomedich-819	1	87	universitas	universitas	PROPN
biomedich-819	1	88	palangka	palangka	PROPN
biomedich-819	1	89	raya	raya	PROPN
biomedich-819	1	90	,	,	PUNCT
biomedich-819	1	91	indonesia	indonesia	PROPN
biomedich-819	1	92	.	.	PUNCT
biomedich-819	2	1	2department	2department	NUM
biomedich-819	2	2	of	of	ADP
biomedich-819	2	3	microbiology	microbiology	NOUN
biomedich-819	2	4	,	,	PUNCT
biomedich-819	2	5	faculty	faculty	NOUN
biomedich-819	2	6	of	of	ADP
biomedich-819	2	7	medicine	medicine	NOUN
biomedich-819	2	8	,	,	PUNCT
biomedich-819	2	9	universitas	universitas	PROPN
biomedich-819	2	10	palangka	palangka	PROPN
biomedich-819	2	11	raya	raya	PROPN
biomedich-819	2	12	,	,	PUNCT
biomedich-819	2	13	indonesia	indonesia	PROPN
biomedich-819	2	14	.	.	PUNCT
biomedich-819	3	1	3department	3department	NUM
biomedich-819	3	2	of	of	ADP
biomedich-819	3	3	clinical	clinical	ADJ
biomedich-819	3	4	medicine	medicine	NOUN
biomedich-819	3	5	,	,	PUNCT
biomedich-819	3	6	faculty	faculty	NOUN
biomedich-819	3	7	of	of	ADP
biomedich-819	3	8	medicine	medicine	NOUN
biomedich-819	3	9	,	,	PUNCT
biomedich-819	3	10	universitas	universitas	PROPN
biomedich-819	3	11	palangka	palangka	PROPN
biomedich-819	3	12	raya	raya	PROPN
biomedich-819	3	13	,	,	PUNCT
biomedich-819	3	14	indonesia	indonesia	PROPN
biomedich-819	3	15	.	.	PUNCT
biomedich-819	4	1	4department	4department	NUM
biomedich-819	4	2	of	of	ADP
biomedich-819	4	3	pharmacotherapy	pharmacotherapy	NOUN
biomedich-819	4	4	,	,	PUNCT
biomedich-819	4	5	faculty	faculty	NOUN
biomedich-819	4	6	of	of	ADP
biomedich-819	4	7	medicine	medicine	NOUN
biomedich-819	4	8	,	,	PUNCT
biomedich-819	4	9	universitas	universitas	PROPN
biomedich-819	4	10	palangka	palangka	PROPN
biomedich-819	4	11	raya	raya	PROPN
biomedich-819	4	12	,	,	PUNCT
biomedich-819	4	13	indonesia	indonesia	PROPN
biomedich-819	4	14	.	.	PUNCT
biomedich-819	5	1	corresponding	correspond	VERB
biomedich-819	5	2	author	author	NOUN
biomedich-819	5	3	*	*	X
biomedich-819	5	4	riankapraja@med.upr.ac.id	riankapraja@med.upr.ac.id	X
biomedich-819	5	5	abstract	abstract	ADJ
biomedich-819	5	6	antibiotic	antibiotic	ADJ
biomedich-819	5	7	resistance	resistance	NOUN
biomedich-819	5	8	in	in	ADP
biomedich-819	5	9	staphylococcus	staphylococcus	NOUN
biomedich-819	5	10	aureus	aureus	NOUN
biomedich-819	5	11	infections	infection	NOUN
biomedich-819	5	12	,	,	PUNCT
biomedich-819	5	13	especially	especially	ADV
biomedich-819	5	14	those	those	PRON
biomedich-819	5	15	involving	involve	VERB
biomedich-819	5	16	biofilm	biofilm	NOUN
biomedich-819	5	17	formation	formation	NOUN
biomedich-819	5	18	,	,	PUNCT
biomedich-819	5	19	is	be	AUX
biomedich-819	5	20	a	a	DET
biomedich-819	5	21	global	global	ADJ
biomedich-819	5	22	health	health	NOUN
biomedich-819	5	23	issue	issue	NOUN
biomedich-819	5	24	.	.	PUNCT
biomedich-819	6	1	biofilm	biofilm	NOUN
biomedich-819	6	2	protects	protect	VERB
biomedich-819	6	3	bacteria	bacteria	NOUN
biomedich-819	6	4	from	from	ADP
biomedich-819	6	5	the	the	DET
biomedich-819	6	6	immune	immune	ADJ
biomedich-819	6	7	system	system	NOUN
biomedich-819	6	8	and	and	CCONJ
biomedich-819	6	9	antibiotic	antibiotic	ADJ
biomedich-819	6	10	treatment	treatment	NOUN
biomedich-819	6	11	,	,	PUNCT
biomedich-819	6	12	making	make	VERB
biomedich-819	6	13	them	they	PRON
biomedich-819	6	14	10	10	NUM
biomedich-819	6	15	to	to	PART
biomedich-819	6	16	1000	1000	NUM
biomedich-819	6	17	times	time	NOUN
biomedich-819	6	18	more	more	ADV
biomedich-819	6	19	resistant	resistant	ADJ
biomedich-819	6	20	.	.	PUNCT
biomedich-819	7	1	the	the	DET
biomedich-819	7	2	icad	icad	PROPN
biomedich-819	7	3	gene	gene	NOUN
biomedich-819	7	4	,	,	PUNCT
biomedich-819	7	5	part	part	NOUN
biomedich-819	7	6	of	of	ADP
biomedich-819	7	7	the	the	DET
biomedich-819	7	8	ica	ica	PROPN
biomedich-819	7	9	operon	operon	PROPN
biomedich-819	7	10	,	,	PUNCT
biomedich-819	7	11	is	be	AUX
biomedich-819	7	12	crucial	crucial	ADJ
biomedich-819	7	13	for	for	ADP
biomedich-819	7	14	biofilm	biofilm	NOUN
biomedich-819	7	15	synthesis	synthesis	NOUN
biomedich-819	7	16	by	by	ADP
biomedich-819	7	17	enhancing	enhance	VERB
biomedich-819	7	18	the	the	DET
biomedich-819	7	19	enzymes	enzyme	NOUN
biomedich-819	7	20	responsible	responsible	ADJ
biomedich-819	7	21	for	for	ADP
biomedich-819	7	22	forming	form	VERB
biomedich-819	7	23	the	the	DET
biomedich-819	7	24	biofilm	biofilm	NOUN
biomedich-819	7	25	matrix	matrix	NOUN
biomedich-819	7	26	.	.	PUNCT
biomedich-819	8	1	the	the	DET
biomedich-819	8	2	icad	icad	PROPN
biomedich-819	8	3	gene	gene	NOUN
biomedich-819	8	4	sequence	sequence	NOUN
biomedich-819	8	5	of	of	ADP
biomedich-819	8	6	staphylococcus	staphylococcus	NOUN
biomedich-819	8	7	aureus	aureus	NOUN
biomedich-819	8	8	was	be	AUX
biomedich-819	8	9	obtained	obtain	VERB
biomedich-819	8	10	from	from	ADP
biomedich-819	8	11	the	the	DET
biomedich-819	8	12	genbank	genbank	PROPN
biomedich-819	8	13	ncbi	ncbi	PROPN
biomedich-819	8	14	database	database	NOUN
biomedich-819	8	15	with	with	ADP
biomedich-819	8	16	the	the	DET
biomedich-819	8	17	accession	accession	NOUN
biomedich-819	8	18	code	code	NOUN
biomedich-819	8	19	cp140612.1	cp140612.1	NOUN
biomedich-819	8	20	,	,	PUNCT
biomedich-819	8	21	with	with	ADP
biomedich-819	8	22	a	a	DET
biomedich-819	8	23	gene	gene	NOUN
biomedich-819	8	24	sequence	sequence	NOUN
biomedich-819	8	25	length	length	NOUN
biomedich-819	8	26	of	of	ADP
biomedich-819	8	27	306	306	NUM
biomedich-819	8	28	bp	bp	NOUN
biomedich-819	8	29	and	and	CCONJ
biomedich-819	8	30	employed	employ	VERB
biomedich-819	8	31	several	several	ADJ
biomedich-819	8	32	bioinformatics	bioinformatics	NOUN
biomedich-819	8	33	methods	method	NOUN
biomedich-819	8	34	,	,	PUNCT
biomedich-819	8	35	including	include	VERB
biomedich-819	8	36	sidirect	sidirect	NOUN
biomedich-819	8	37	for	for	ADP
biomedich-819	8	38	designing	design	VERB
biomedich-819	8	39	and	and	CCONJ
biomedich-819	8	40	evaluating	evaluate	VERB
biomedich-819	8	41	effective	effective	ADJ
biomedich-819	8	42	sirna	sirna	PROPN
biomedich-819	8	43	sequences	sequence	NOUN
biomedich-819	8	44	to	to	PART
biomedich-819	8	45	select	select	VERB
biomedich-819	8	46	the	the	DET
biomedich-819	8	47	most	most	ADV
biomedich-819	8	48	promising	promising	ADJ
biomedich-819	8	49	candidates	candidate	NOUN
biomedich-819	8	50	.	.	PUNCT
biomedich-819	9	1	additionally	additionally	ADV
biomedich-819	9	2	,	,	PUNCT
biomedich-819	9	3	sirna	sirna	PROPN
biomedich-819	9	4	scales	scale	NOUN
biomedich-819	9	5	,	,	PUNCT
biomedich-819	9	6	maxexpect	maxexpect	ADJ
biomedich-819	9	7	,	,	PUNCT
biomedich-819	9	8	duplex	duplex	NOUN
biomedich-819	9	9	fold	fold	NOUN
biomedich-819	9	10	,	,	PUNCT
biomedich-819	9	11	and	and	CCONJ
biomedich-819	9	12	sipred	sipre	VERB
biomedich-819	9	13	were	be	AUX
biomedich-819	9	14	employed	employ	VERB
biomedich-819	9	15	to	to	PART
biomedich-819	9	16	analyze	analyze	VERB
biomedich-819	9	17	the	the	DET
biomedich-819	9	18	sirna	sirna	PROPN
biomedich-819	9	19	sequence	sequence	PROPN
biomedich-819	9	20	length	length	NOUN
biomedich-819	9	21	,	,	PUNCT
biomedich-819	9	22	secondary	secondary	ADJ
biomedich-819	9	23	structure	structure	NOUN
biomedich-819	9	24	,	,	PUNCT
biomedich-819	9	25	binding	bind	VERB
biomedich-819	9	26	energy	energy	NOUN
biomedich-819	9	27	,	,	PUNCT
biomedich-819	9	28	and	and	CCONJ
biomedich-819	9	29	efficacy	efficacy	NOUN
biomedich-819	9	30	predictions	prediction	NOUN
biomedich-819	9	31	of	of	ADP
biomedich-819	9	32	sirnas	sirna	NOUN
biomedich-819	9	33	targeting	target	VERB
biomedich-819	9	34	the	the	DET
biomedich-819	9	35	icad	icad	PROPN
biomedich-819	9	36	gene	gene	NOUN
biomedich-819	9	37	.	.	PUNCT
biomedich-819	10	1	the	the	DET
biomedich-819	10	2	study	study	NOUN
biomedich-819	10	3	found	find	VERB
biomedich-819	10	4	that	that	SCONJ
biomedich-819	10	5	out	out	ADP
biomedich-819	10	6	of	of	ADP
biomedich-819	10	7	54	54	NUM
biomedich-819	10	8	sirna	sirna	PROPN
biomedich-819	10	9	candidates	candidate	NOUN
biomedich-819	10	10	,	,	PUNCT
biomedich-819	10	11	sirna22	sirna22	NOUN
biomedich-819	10	12	,	,	PUNCT
biomedich-819	10	13	sirna50	sirna50	NOUN
biomedich-819	10	14	,	,	PUNCT
biomedich-819	10	15	and	and	CCONJ
biomedich-819	10	16	sirna25	sirna25	NOUN
biomedich-819	10	17	achieved	achieve	VERB
biomedich-819	10	18	inhibition	inhibition	NOUN
biomedich-819	10	19	rates	rate	NOUN
biomedich-819	10	20	of	of	ADP
biomedich-819	10	21	93.69	93.69	NUM
biomedich-819	10	22	%	%	NOUN
biomedich-819	10	23	,	,	PUNCT
biomedich-819	10	24	92.82	92.82	NUM
biomedich-819	10	25	%	%	NOUN
biomedich-819	10	26	,	,	PUNCT
biomedich-819	10	27	and	and	CCONJ
biomedich-819	10	28	92.52	92.52	NUM
biomedich-819	10	29	%	%	NOUN
biomedich-819	10	30	,	,	PUNCT
biomedich-819	10	31	respectively	respectively	ADV
biomedich-819	10	32	.	.	PUNCT
biomedich-819	11	1	these	these	DET
biomedich-819	11	2	results	result	NOUN
biomedich-819	11	3	bioinformatically	bioinformatically	ADV
biomedich-819	11	4	demonstrated	demonstrate	VERB
biomedich-819	11	5	their	their	PRON
biomedich-819	11	6	potential	potential	NOUN
biomedich-819	11	7	to	to	PART
biomedich-819	11	8	suppress	suppress	VERB
biomedich-819	11	9	the	the	DET
biomedich-819	11	10	expression	expression	NOUN
biomedich-819	11	11	of	of	ADP
biomedich-819	11	12	the	the	DET
biomedich-819	11	13	icad	icad	ADJ
biomedich-819	11	14	gene	gene	NOUN
biomedich-819	11	15	and	and	CCONJ
biomedich-819	11	16	highlight	highlight	VERB
biomedich-819	11	17	their	their	PRON
biomedich-819	11	18	promise	promise	NOUN
biomedich-819	11	19	as	as	ADP
biomedich-819	11	20	sirna	sirna	PROPN
biomedich-819	11	21	-	-	PUNCT
biomedich-819	11	22	based	base	VERB
biomedich-819	11	23	antibacterial	antibacterial	ADJ
biomedich-819	11	24	therapies	therapy	NOUN
biomedich-819	11	25	to	to	ADP
biomedich-819	11	26	combat	combat	NOUN
biomedich-819	11	27	biofilm	biofilm	NOUN
biomedich-819	11	28	-	-	PUNCT
biomedich-819	11	29	related	relate	VERB
biomedich-819	11	30	infections	infection	NOUN
biomedich-819	11	31	.	.	PUNCT
biomedich-819	12	1	the	the	DET
biomedich-819	12	2	designed	design	VERB
biomedich-819	12	3	sirna	sirna	PROPN
biomedich-819	12	4	computationally	computationally	ADV
biomedich-819	12	5	shows	show	VERB
biomedich-819	12	6	potential	potential	ADJ
biomedich-819	12	7	as	as	ADP
biomedich-819	12	8	an	an	DET
biomedich-819	12	9	innovative	innovative	ADJ
biomedich-819	12	10	therapy	therapy	NOUN
biomedich-819	12	11	to	to	PART
biomedich-819	12	12	combat	combat	VERB
biomedich-819	12	13	biofilm	biofilm	NOUN
biomedich-819	12	14	infections	infection	NOUN
biomedich-819	12	15	caused	cause	VERB
biomedich-819	12	16	by	by	ADP
biomedich-819	12	17	staphylococcus	staphylococcus	NOUN
biomedich-819	12	18	aureus	aureus	NOUN
biomedich-819	12	19	.	.	PUNCT
biomedich-819	13	1	keywords	keyword	NOUN
biomedich-819	13	2	:	:	PUNCT
biomedich-819	13	3	staphylococcus	staphylococcus	NOUN
biomedich-819	13	4	aureus	aureus	NOUN
biomedich-819	13	5	;	;	PUNCT
biomedich-819	13	6	biofilm	biofilm	NOUN
biomedich-819	13	7	;	;	PUNCT
biomedich-819	13	8	icad	icad	ADJ
biomedich-819	13	9	gene	gene	NOUN
biomedich-819	13	10	;	;	PUNCT
biomedich-819	13	11	sirna	sirna	PROPN
biomedich-819	13	12	;	;	PUNCT
biomedich-819	13	13	antibiotic	antibiotic	ADJ
biomedich-819	13	14	resistance	resistance	NOUN
biomedich-819	13	15	.	.	PUNCT
biomedich-819	14	1	introduction	introduction	NOUN
biomedich-819	14	2	antimicrobial	antimicrobial	ADJ
biomedich-819	14	3	resistance	resistance	NOUN
biomedich-819	14	4	(	(	PUNCT
biomedich-819	14	5	amr	amr	NOUN
biomedich-819	14	6	)	)	PUNCT
biomedich-819	14	7	is	be	AUX
biomedich-819	14	8	one	one	NUM
biomedich-819	14	9	of	of	ADP
biomedich-819	14	10	the	the	DET
biomedich-819	14	11	top	top	ADJ
biomedich-819	14	12	global	global	NOUN
biomedich-819	14	13	to	to	ADP
biomedich-819	14	14	public	public	ADJ
biomedich-819	14	15	health	health	NOUN
biomedich-819	14	16	and	and	CCONJ
biomedich-819	14	17	development	development	NOUN
biomedich-819	14	18	.	.	PUNCT
biomedich-819	15	1	it	it	PRON
biomedich-819	15	2	is	be	AUX
biomedich-819	15	3	estimated	estimate	VERB
biomedich-819	15	4	that	that	SCONJ
biomedich-819	15	5	bacterial	bacterial	ADJ
biomedich-819	15	6	amr	amr	NOUN
biomedich-819	15	7	was	be	AUX
biomedich-819	15	8	directly	directly	ADV
biomedich-819	15	9	responsible	responsible	ADJ
biomedich-819	15	10	for	for	ADP
biomedich-819	15	11	1.27	1.27	NUM
biomedich-819	15	12	million	million	NUM
biomedich-819	15	13	global	global	ADJ
biomedich-819	15	14	deaths	death	NOUN
biomedich-819	15	15	in	in	ADP
biomedich-819	15	16	2019	2019	NUM
biomedich-819	15	17	and	and	CCONJ
biomedich-819	15	18	contributed	contribute	VERB
biomedich-819	15	19	to	to	ADP
biomedich-819	15	20	4.95	4.95	NUM
biomedich-819	15	21	million	million	NUM
biomedich-819	15	22	deaths	death	NOUN
biomedich-819	15	23	(	(	PUNCT
biomedich-819	15	24	murray	murray	PROPN
biomedich-819	15	25	et	et	PROPN
biomedich-819	15	26	al	al	PROPN
biomedich-819	15	27	.	.	PROPN
biomedich-819	15	28	,	,	PUNCT
biomedich-819	15	29	2022	2022	NUM
biomedich-819	15	30	)	)	PUNCT
biomedich-819	15	31	.	.	PUNCT
biomedich-819	16	1	staphylococcus	staphylococcus	NOUN
biomedich-819	16	2	aureus	aureus	PROPN
biomedich-819	16	3	(	(	PUNCT
biomedich-819	16	4	s.	s.	PROPN
biomedich-819	16	5	aureus	aureus	PROPN
biomedich-819	16	6	)	)	PUNCT
biomedich-819	16	7	,	,	PUNCT
biomedich-819	16	8	which	which	PRON
biomedich-819	16	9	often	often	ADV
biomedich-819	16	10	forms	form	VERB
biomedich-819	16	11	biofilms	biofilm	NOUN
biomedich-819	16	12	,	,	PUNCT
biomedich-819	16	13	is	be	AUX
biomedich-819	16	14	becoming	become	VERB
biomedich-819	16	15	increasingly	increasingly	ADV
biomedich-819	16	16	difficult	difficult	ADJ
biomedich-819	16	17	to	to	PART
biomedich-819	16	18	treat	treat	VERB
biomedich-819	16	19	,	,	PUNCT
biomedich-819	16	20	especially	especially	ADV
biomedich-819	16	21	strains	strain	NOUN
biomedich-819	16	22	resistant	resistant	ADJ
biomedich-819	16	23	to	to	ADP
biomedich-819	16	24	methicillin	methicillin	NOUN
biomedich-819	16	25	(	(	PUNCT
biomedich-819	16	26	mrsa	mrsa	NOUN
biomedich-819	16	27	)	)	PUNCT
biomedich-819	16	28	.	.	PUNCT
biomedich-819	17	1	bacterial	bacterial	ADJ
biomedich-819	17	2	biofilms	biofilm	NOUN
biomedich-819	17	3	protect	protect	VERB
biomedich-819	17	4	them	they	PRON
biomedich-819	17	5	from	from	ADP
biomedich-819	17	6	the	the	DET
biomedich-819	17	7	immune	immune	ADJ
biomedich-819	17	8	system	system	NOUN
biomedich-819	17	9	and	and	CCONJ
biomedich-819	17	10	antibiotics	antibiotic	NOUN
biomedich-819	17	11	,	,	PUNCT
biomedich-819	17	12	making	make	VERB
biomedich-819	17	13	them	they	PRON
biomedich-819	17	14	10	10	NUM
biomedich-819	17	15	-	-	SYM
biomedich-819	17	16	1000	1000	NUM
biomedich-819	17	17	times	time	NOUN
biomedich-819	17	18	more	more	ADV
biomedich-819	17	19	resistant	resistant	ADJ
biomedich-819	17	20	(	(	PUNCT
biomedich-819	17	21	tran	tran	NOUN
biomedich-819	17	22	et	et	PROPN
biomedich-819	17	23	al	al	PROPN
biomedich-819	17	24	.	.	PROPN
biomedich-819	17	25	,	,	PUNCT
biomedich-819	17	26	2023	2023	NUM
biomedich-819	17	27	)	)	PUNCT
biomedich-819	17	28	.	.	PUNCT
biomedich-819	18	1	biofilm	biofilm	NOUN
biomedich-819	18	2	formation	formation	NOUN
biomedich-819	18	3	in	in	ADP
biomedich-819	18	4	s.	s.	PROPN
biomedich-819	18	5	aureus	aureus	PROPN
biomedich-819	18	6	is	be	AUX
biomedich-819	18	7	encoded	encode	VERB
biomedich-819	18	8	by	by	ADP
biomedich-819	18	9	several	several	ADJ
biomedich-819	18	10	genes	gene	NOUN
biomedich-819	18	11	,	,	PUNCT
biomedich-819	18	12	including	include	VERB
biomedich-819	18	13	icaa	icaa	NOUN
biomedich-819	18	14	,	,	PUNCT
biomedich-819	18	15	icab	icab	NOUN
biomedich-819	18	16	,	,	PUNCT
biomedich-819	18	17	icac	icac	NOUN
biomedich-819	18	18	,	,	PUNCT
biomedich-819	18	19	and	and	CCONJ
biomedich-819	18	20	icad	icad	PROPN
biomedich-819	18	21	,	,	PUNCT
biomedich-819	18	22	which	which	PRON
biomedich-819	18	23	are	be	AUX
biomedich-819	18	24	involved	involve	VERB
biomedich-819	18	25	in	in	ADP
biomedich-819	18	26	the	the	DET
biomedich-819	18	27	biofilm	biofilm	NOUN
biomedich-819	18	28	matrix	matrix	NOUN
biomedich-819	18	29	formation	formation	NOUN
biomedich-819	18	30	(	(	PUNCT
biomedich-819	18	31	peng	peng	PROPN
biomedich-819	18	32	et	et	PROPN
biomedich-819	18	33	al	al	PROPN
biomedich-819	18	34	.	.	PROPN
biomedich-819	18	35	,	,	PUNCT
biomedich-819	18	36	2023	2023	NUM
biomedich-819	18	37	)	)	PUNCT
biomedich-819	18	38	.	.	PUNCT
biomedich-819	19	1	one	one	NUM
biomedich-819	19	2	promising	promise	VERB
biomedich-819	19	3	therapeutic	therapeutic	ADJ
biomedich-819	19	4	approach	approach	NOUN
biomedich-819	19	5	is	be	AUX
biomedich-819	19	6	the	the	DET
biomedich-819	19	7	use	use	NOUN
biomedich-819	19	8	of	of	ADP
biomedich-819	19	9	small	small	ADJ
biomedich-819	19	10	interfering	interfere	VERB
biomedich-819	19	11	rna	rna	PROPN
biomedich-819	19	12	(	(	PUNCT
biomedich-819	19	13	sirna	sirna	PROPN
biomedich-819	19	14	)	)	PUNCT
biomedich-819	19	15	to	to	PART
biomedich-819	19	16	inhibit	inhibit	VERB
biomedich-819	19	17	the	the	DET
biomedich-819	19	18	expression	expression	NOUN
biomedich-819	19	19	of	of	ADP
biomedich-819	19	20	the	the	DET
biomedich-819	19	21	icad	icad	PROPN
biomedich-819	19	22	gene	gene	NOUN
biomedich-819	19	23	,	,	PUNCT
biomedich-819	19	24	which	which	PRON
biomedich-819	19	25	plays	play	VERB
biomedich-819	19	26	a	a	DET
biomedich-819	19	27	role	role	NOUN
biomedich-819	19	28	in	in	ADP
biomedich-819	19	29	biofilm	biofilm	NOUN
biomedich-819	19	30	formation	formation	NOUN
biomedich-819	19	31	.	.	PUNCT
biomedich-819	20	1	sirna	sirna	PROPN
biomedich-819	20	2	can	can	AUX
biomedich-819	20	3	regulate	regulate	VERB
biomedich-819	20	4	gene	gene	NOUN
biomedich-819	20	5	expression	expression	NOUN
biomedich-819	20	6	through	through	ADP
biomedich-819	20	7	the	the	DET
biomedich-819	20	8	rna	rna	NOUN
biomedich-819	20	9	interference	interference	NOUN
biomedich-819	20	10	(	(	PUNCT
biomedich-819	20	11	rnai	rnai	NOUN
biomedich-819	20	12	)	)	PUNCT
biomedich-819	20	13	mechanism	mechanism	NOUN
biomedich-819	20	14	,	,	PUNCT
biomedich-819	20	15	which	which	PRON
biomedich-819	20	16	targets	target	VERB
biomedich-819	20	17	mrna	mrna	PROPN
biomedich-819	20	18	and	and	CCONJ
biomedich-819	20	19	inhibits	inhibit	VERB
biomedich-819	20	20	the	the	DET
biomedich-819	20	21	translation	translation	NOUN
biomedich-819	20	22	of	of	ADP
biomedich-819	20	23	specific	specific	ADJ
biomedich-819	20	24	proteins	protein	NOUN
biomedich-819	20	25	.	.	PUNCT
biomedich-819	21	1	with	with	ADP
biomedich-819	21	2	the	the	DET
biomedich-819	21	3	advancement	advancement	NOUN
biomedich-819	21	4	of	of	ADP
biomedich-819	21	5	bioinformatics	bioinformatics	NOUN
biomedich-819	21	6	technology	technology	NOUN
biomedich-819	21	7	,	,	PUNCT
biomedich-819	21	8	the	the	DET
biomedich-819	21	9	analysis	analysis	NOUN
biomedich-819	21	10	of	of	ADP
biomedich-819	21	11	sirna	sirna	PROPN
biomedich-819	21	12	structure	structure	NOUN
biomedich-819	21	13	and	and	CCONJ
biomedich-819	21	14	efficacy	efficacy	NOUN
biomedich-819	21	15	has	have	AUX
biomedich-819	21	16	become	become	VERB
biomedich-819	21	17	easier	easy	ADJ
biomedich-819	21	18	.	.	PUNCT
biomedich-819	22	1	previously	previously	ADV
biomedich-819	22	2	,	,	PUNCT
biomedich-819	22	3	sirna	sirna	PROPN
biomedich-819	22	4	has	have	AUX
biomedich-819	22	5	been	be	AUX
biomedich-819	22	6	used	use	VERB
biomedich-819	22	7	for	for	ADP
biomedich-819	22	8	antiviral	antiviral	ADJ
biomedich-819	22	9	therapy	therapy	NOUN
biomedich-819	22	10	,	,	PUNCT
biomedich-819	22	11	such	such	ADJ
biomedich-819	22	12	as	as	ADP
biomedich-819	22	13	for	for	ADP
biomedich-819	22	14	hepatitis	hepatitis	PROPN
biomedich-819	22	15	c	c	PROPN
biomedich-819	22	16	and	and	CCONJ
biomedich-819	22	17	zika	zika	X
biomedich-819	22	18	virus	virus	NOUN
biomedich-819	22	19	infections	infection	NOUN
biomedich-819	22	20	(	(	PUNCT
biomedich-819	22	21	perezmendez	perezmendez	PROPN
biomedich-819	22	22	et	et	PROPN
biomedich-819	22	23	al	al	PROPN
biomedich-819	22	24	.	.	PROPN
biomedich-819	22	25	,	,	PUNCT
biomedich-819	22	26	2020	2020	NUM
biomedich-819	22	27	)	)	PUNCT
biomedich-819	22	28	.	.	PUNCT
biomedich-819	23	1	this	this	DET
biomedich-819	23	2	study	study	NOUN
biomedich-819	23	3	aimed	aim	VERB
biomedich-819	23	4	to	to	PART
biomedich-819	23	5	explore	explore	VERB
biomedich-819	23	6	,	,	PUNCT
biomedich-819	23	7	analyze	analyze	VERB
biomedich-819	23	8	the	the	DET
biomedich-819	23	9	structure	structure	NOUN
biomedich-819	23	10	,	,	PUNCT
biomedich-819	23	11	and	and	CCONJ
biomedich-819	23	12	predict	predict	VERB
biomedich-819	23	13	the	the	DET
biomedich-819	23	14	efficacy	efficacy	NOUN
biomedich-819	23	15	of	of	ADP
biomedich-819	23	16	sirna	sirna	PROPN
biomedich-819	23	17	to	to	PART
biomedich-819	23	18	suppress	suppress	VERB
biomedich-819	23	19	the	the	DET
biomedich-819	23	20	expression	expression	NOUN
biomedich-819	23	21	of	of	ADP
biomedich-819	23	22	the	the	DET
biomedich-819	23	23	icad	icad	PROPN
biomedich-819	23	24	gene	gene	NOUN
biomedich-819	23	25	in	in	ADP
biomedich-819	23	26	s.	s.	PROPN
biomedich-819	23	27	aureus	aureus	PROPN
biomedich-819	23	28	as	as	ADP
biomedich-819	23	29	a	a	DET
biomedich-819	23	30	strategy	strategy	NOUN
biomedich-819	23	31	to	to	PART
biomedich-819	23	32	combat	combat	NOUN
biomedich-819	23	33	infections	infection	NOUN
biomedich-819	23	34	caused	cause	VERB
biomedich-819	23	35	by	by	ADP
biomedich-819	23	36	bacterial	bacterial	ADJ
biomedich-819	23	37	biofilms	biofilm	NOUN
biomedich-819	23	38	.	.	PUNCT
biomedich-819	24	1	materials	material	NOUN
biomedich-819	24	2	and	and	CCONJ
biomedich-819	24	3	methods	method	NOUN
biomedich-819	24	4	study	study	NOUN
biomedich-819	24	5	area	area	NOUN
biomedich-819	24	6	the	the	DET
biomedich-819	24	7	study	study	NOUN
biomedich-819	24	8	took	take	VERB
biomedich-819	24	9	place	place	NOUN
biomedich-819	24	10	in	in	ADP
biomedich-819	24	11	faculty	faculty	NOUN
biomedich-819	24	12	of	of	ADP
biomedich-819	24	13	medicine	medicine	PROPN
biomedich-819	24	14	palangka	palangka	PROPN
biomedich-819	24	15	raya	raya	PROPN
biomedich-819	24	16	university	university	PROPN
biomedich-819	24	17	between	between	ADP
biomedich-819	24	18	june	june	PROPN
biomedich-819	24	19	and	and	CCONJ
biomedich-819	24	20	desember	desember	PROPN
biomedich-819	24	21	2024	2024	NUM
biomedich-819	24	22	.	.	PUNCT
biomedich-819	25	1	procedures	procedure	NOUN
biomedich-819	25	2	retrieval	retrieval	NOUN
biomedich-819	25	3	of	of	ADP
biomedich-819	25	4	the	the	DET
biomedich-819	25	5	icad	icad	PROPN
biomedich-819	25	6	gene	gene	NOUN
biomedich-819	25	7	sequence	sequence	NOUN
biomedich-819	25	8	the	the	DET
biomedich-819	25	9	downloaded	download	VERB
biomedich-819	25	10	fasta	fasta	PROPN
biomedich-819	25	11	sequence	sequence	NOUN
biomedich-819	25	12	of	of	ADP
biomedich-819	25	13	the	the	DET
biomedich-819	25	14	icad	icad	PROPN
biomedich-819	25	15	gene	gene	NOUN
biomedich-819	25	16	from	from	ADP
biomedich-819	25	17	staphylococcus	staphylococcus	NOUN
biomedich-819	25	18	aureus	aureus	PROPN
biomedich-819	25	19	(	(	PUNCT
biomedich-819	25	20	ncbi	ncbi	PROPN
biomedich-819	25	21	accession	accession	NOUN
biomedich-819	25	22	number	number	NOUN
biomedich-819	25	23	:	:	PUNCT
biomedich-819	25	24	cp140612.1	cp140612.1	X
biomedich-819	25	25	)	)	PUNCT
biomedich-819	25	26	was	be	AUX
biomedich-819	25	27	renamed	rename	VERB
biomedich-819	25	28	accordingly	accordingly	ADV
biomedich-819	25	29	and	and	CCONJ
biomedich-819	25	30	stored	store	VERB
biomedich-819	25	31	in	in	ADP
biomedich-819	25	32	a	a	DET
biomedich-819	25	33	dedicated	dedicated	ADJ
biomedich-819	25	34	folder	folder	NOUN
biomedich-819	25	35	for	for	ADP
biomedich-819	25	36	further	further	ADJ
biomedich-819	25	37	analysis	analysis	NOUN
biomedich-819	25	38	.	.	PUNCT
biomedich-819	26	1	the	the	DET
biomedich-819	26	2	sequence	sequence	NOUN
biomedich-819	26	3	was	be	AUX
biomedich-819	26	4	then	then	ADV
biomedich-819	26	5	utilized	utilize	VERB
biomedich-819	26	6	to	to	PART
biomedich-819	26	7	perform	perform	VERB
biomedich-819	26	8	several	several	ADJ
biomedich-819	26	9	computational	computational	ADJ
biomedich-819	26	10	analyses	analysis	NOUN
biomedich-819	26	11	,	,	PUNCT
biomedich-819	26	12	including	include	VERB
biomedich-819	26	13	the	the	DET
biomedich-819	26	14	design	design	NOUN
biomedich-819	26	15	of	of	ADP
biomedich-819	26	16	sirna	sirna	PROPN
biomedich-819	26	17	molecules	molecule	NOUN
biomedich-819	26	18	targeting	target	VERB
biomedich-819	26	19	the	the	DET
biomedich-819	26	20	icad	icad	PROPN
biomedich-819	26	21	gene	gene	NOUN
biomedich-819	26	22	,	,	PUNCT
biomedich-819	26	23	analysis	analysis	NOUN
biomedich-819	26	24	of	of	ADP
biomedich-819	26	25	mrna	mrna	PROPN
biomedich-819	26	26	length	length	PROPN
biomedich-819	26	27	percentage	percentage	NOUN
biomedich-819	26	28	,	,	PUNCT
biomedich-819	26	29	prediction	prediction	NOUN
biomedich-819	26	30	of	of	ADP
biomedich-819	26	31	the	the	DET
biomedich-819	26	32	secondary	secondary	ADJ
biomedich-819	26	33	structure	structure	NOUN
biomedich-819	26	34	of	of	ADP
biomedich-819	26	35	the	the	DET
biomedich-819	26	36	designed	design	VERB
biomedich-819	26	37	manuscript	manuscript	NOUN
biomedich-819	26	38	received	receive	VERB
biomedich-819	26	39	:	:	PUNCT
biomedich-819	26	40	08	08	NUM
biomedich-819	26	41	june	june	PROPN
biomedich-819	26	42	,	,	PUNCT
biomedich-819	26	43	2025	2025	NUM
biomedich-819	26	44	.	.	PUNCT
biomedich-819	27	1	revision	revision	NOUN
biomedich-819	27	2	accepted	accept	VERB
biomedich-819	27	3	:	:	PUNCT
biomedich-819	27	4	26	26	NUM
biomedich-819	27	5	october	october	PROPN
biomedich-819	27	6	,	,	PUNCT
biomedich-819	27	7	2025	2025	NUM
biomedich-819	27	8	.	.	PUNCT
biomedich-819	28	1	published	publish	VERB
biomedich-819	28	2	:	:	PUNCT
biomedich-819	28	3	28	28	NUM
biomedich-819	28	4	october	october	PROPN
biomedich-819	28	5	,	,	PUNCT
biomedich-819	28	6	2025	2025	NUM
biomedich-819	28	7	.	.	PUNCT
biomedich-819	29	1	https://doi.org/10.14421/biomedich.2025.142.921-926	https://doi.org/10.14421/biomedich.2025.142.921-926	NOUN
biomedich-819	29	2	mailto:riankapraja@med.upr.ac.id	mailto:riankapraja@med.upr.ac.id	NOUN
biomedich-819	29	3	922	922	NUM
biomedich-819	29	4	biology	biology	NOUN
biomedich-819	29	5	,	,	PUNCT
biomedich-819	29	6	medicine	medicine	NOUN
biomedich-819	29	7	,	,	PUNCT
biomedich-819	29	8	&	&	CCONJ
biomedich-819	29	9	natural	natural	ADJ
biomedich-819	29	10	product	product	NOUN
biomedich-819	29	11	chemistry	chemistry	NOUN
biomedich-819	29	12	14	14	NUM
biomedich-819	29	13	(	(	PUNCT
biomedich-819	29	14	2	2	NUM
biomedich-819	29	15	)	)	PUNCT
biomedich-819	29	16	,	,	PUNCT
biomedich-819	29	17	2025	2025	NUM
biomedich-819	29	18	:	:	PUNCT
biomedich-819	29	19	921	921	NUM
biomedich-819	29	20	-	-	SYM
biomedich-819	29	21	926	926	NUM
biomedich-819	29	22	sirnas	sirna	NOUN
biomedich-819	29	23	,	,	PUNCT
biomedich-819	29	24	calculation	calculation	NOUN
biomedich-819	29	25	of	of	ADP
biomedich-819	29	26	binding	bind	VERB
biomedich-819	29	27	energies	energy	NOUN
biomedich-819	29	28	between	between	ADP
biomedich-819	29	29	sirna	sirna	PROPN
biomedich-819	29	30	and	and	CCONJ
biomedich-819	29	31	target	target	PROPN
biomedich-819	29	32	mrna	mrna	PROPN
biomedich-819	29	33	,	,	PUNCT
biomedich-819	29	34	and	and	CCONJ
biomedich-819	29	35	prediction	prediction	NOUN
biomedich-819	29	36	of	of	ADP
biomedich-819	29	37	sirna	sirna	PROPN
biomedich-819	29	38	efficacy	efficacy	PROPN
biomedich-819	29	39	in	in	ADP
biomedich-819	29	40	silencing	silence	VERB
biomedich-819	29	41	the	the	DET
biomedich-819	29	42	icad	icad	ADJ
biomedich-819	29	43	transcript	transcript	NOUN
biomedich-819	29	44	.	.	PUNCT
biomedich-819	30	1	these	these	DET
biomedich-819	30	2	analyses	analysis	NOUN
biomedich-819	30	3	were	be	AUX
biomedich-819	30	4	conducted	conduct	VERB
biomedich-819	30	5	using	use	VERB
biomedich-819	30	6	appropriate	appropriate	ADJ
biomedich-819	30	7	bioinformatics	bioinformatics	NOUN
biomedich-819	30	8	tools	tool	NOUN
biomedich-819	30	9	and	and	CCONJ
biomedich-819	30	10	databases	database	NOUN
biomedich-819	30	11	to	to	PART
biomedich-819	30	12	ensure	ensure	VERB
biomedich-819	30	13	the	the	DET
biomedich-819	30	14	accuracy	accuracy	NOUN
biomedich-819	30	15	and	and	CCONJ
biomedich-819	30	16	reliability	reliability	NOUN
biomedich-819	30	17	of	of	ADP
biomedich-819	30	18	the	the	DET
biomedich-819	30	19	results	result	NOUN
biomedich-819	30	20	.	.	PUNCT
biomedich-819	31	1	design	design	NOUN
biomedich-819	31	2	of	of	ADP
biomedich-819	31	3	gene	gene	NOUN
biomedich-819	31	4	-	-	PUNCT
biomedich-819	31	5	silencing	silence	VERB
biomedich-819	31	6	sirna	sirna	PROPN
biomedich-819	31	7	molecules	molecule	NOUN
biomedich-819	31	8	the	the	DET
biomedich-819	31	9	icad	icad	PROPN
biomedich-819	31	10	gene	gene	NOUN
biomedich-819	31	11	sequence	sequence	NOUN
biomedich-819	31	12	of	of	ADP
biomedich-819	31	13	staphylococcus	staphylococcus	NOUN
biomedich-819	31	14	aureus	aureus	NOUN
biomedich-819	31	15	was	be	AUX
biomedich-819	31	16	obtained	obtain	VERB
biomedich-819	31	17	from	from	ADP
biomedich-819	31	18	the	the	DET
biomedich-819	31	19	genbank	genbank	PROPN
biomedich-819	31	20	ncbi	ncbi	PROPN
biomedich-819	31	21	database	database	NOUN
biomedich-819	31	22	with	with	ADP
biomedich-819	31	23	the	the	DET
biomedich-819	31	24	accession	accession	NOUN
biomedich-819	31	25	code	code	NOUN
biomedich-819	31	26	cp140612.1	cp140612.1	NOUN
biomedich-819	31	27	,	,	PUNCT
biomedich-819	31	28	the	the	DET
biomedich-819	31	29	gene	gene	NOUN
biomedich-819	31	30	sequence	sequence	NOUN
biomedich-819	31	31	is	be	AUX
biomedich-819	31	32	306	306	NUM
biomedich-819	31	33	bp	bp	NOUN
biomedich-819	31	34	long	long	ADV
biomedich-819	31	35	and	and	CCONJ
biomedich-819	31	36	employs	employ	VERB
biomedich-819	31	37	several	several	ADJ
biomedich-819	31	38	bioinformatics	bioinformatics	NOUN
biomedich-819	31	39	methods	method	NOUN
biomedich-819	31	40	.	.	PUNCT
biomedich-819	32	1	the	the	DET
biomedich-819	32	2	design	design	NOUN
biomedich-819	32	3	of	of	ADP
biomedich-819	32	4	sirna	sirna	PROPN
biomedich-819	32	5	to	to	PART
biomedich-819	32	6	silence	silence	VERB
biomedich-819	32	7	the	the	DET
biomedich-819	32	8	s.	s.	PROPN
biomedich-819	32	9	aureus	aureus	PROPN
biomedich-819	32	10	icad	icad	PROPN
biomedich-819	32	11	gene	gene	NOUN
biomedich-819	32	12	was	be	AUX
biomedich-819	32	13	performed	perform	VERB
biomedich-819	32	14	using	use	VERB
biomedich-819	32	15	sidirect	sidirect	NOUN
biomedich-819	32	16	(	(	PUNCT
biomedich-819	32	17	http://sidirect2.rnai.jp/	http://sidirect2.rnai.jp/	PROPN
biomedich-819	32	18	)	)	PUNCT
biomedich-819	32	19	.	.	PUNCT
biomedich-819	33	1	percentage	percentage	NOUN
biomedich-819	33	2	analysis	analysis	NOUN
biomedich-819	33	3	of	of	ADP
biomedich-819	33	4	mrna	mrna	PROPN
biomedich-819	33	5	length	length	NOUN
biomedich-819	33	6	percentage	percentage	NOUN
biomedich-819	33	7	analysis	analysis	NOUN
biomedich-819	33	8	of	of	ADP
biomedich-819	33	9	mrna	mrna	PROPN
biomedich-819	33	10	length	length	NOUN
biomedich-819	33	11	was	be	AUX
biomedich-819	33	12	performed	perform	VERB
biomedich-819	33	13	using	use	VERB
biomedich-819	33	14	sirna	sirna	PROPN
biomedich-819	33	15	scales	scale	NOUN
biomedich-819	33	16	,	,	PUNCT
biomedich-819	33	17	a	a	DET
biomedich-819	33	18	software	software	NOUN
biomedich-819	33	19	that	that	PRON
biomedich-819	33	20	predicts	predict	VERB
biomedich-819	33	21	the	the	DET
biomedich-819	33	22	location	location	NOUN
biomedich-819	33	23	of	of	ADP
biomedich-819	33	24	the	the	DET
biomedich-819	33	25	remaining	remain	VERB
biomedich-819	33	26	mrna	mrna	NOUN
biomedich-819	33	27	sequence	sequence	NOUN
biomedich-819	33	28	in	in	ADP
biomedich-819	33	29	the	the	DET
biomedich-819	33	30	cell	cell	NOUN
biomedich-819	33	31	after	after	ADP
biomedich-819	33	32	sirna	sirna	PROPN
biomedich-819	33	33	cleavage	cleavage	PROPN
biomedich-819	33	34	(	(	PUNCT
biomedich-819	33	35	http://gesteland.genetics.utah.edu/sirna_scales/	http://gesteland.genetics.utah.edu/sirna_scales/	PROPN
biomedich-819	33	36	)	)	PUNCT
biomedich-819	33	37	.	.	PUNCT
biomedich-819	34	1	analysis	analysis	NOUN
biomedich-819	34	2	of	of	ADP
biomedich-819	34	3	the	the	DET
biomedich-819	34	4	secondary	secondary	ADJ
biomedich-819	34	5	structure	structure	NOUN
biomedich-819	34	6	of	of	ADP
biomedich-819	34	7	sirna	sirna	PROPN
biomedich-819	34	8	secondary	secondary	ADJ
biomedich-819	34	9	structure	structure	NOUN
biomedich-819	34	10	analysis	analysis	NOUN
biomedich-819	34	11	of	of	ADP
biomedich-819	34	12	sirna	sirna	PROPN
biomedich-819	34	13	was	be	AUX
biomedich-819	34	14	done	do	VERB
biomedich-819	34	15	using	use	VERB
biomedich-819	34	16	maxexpect	maxexpect	ADV
biomedich-819	34	17	and	and	CCONJ
biomedich-819	34	18	could	could	AUX
biomedich-819	34	19	be	be	AUX
biomedich-819	34	20	accessed	access	VERB
biomedich-819	34	21	through	through	ADP
biomedich-819	34	22	a	a	DET
biomedich-819	34	23	website	website	NOUN
biomedich-819	34	24	https://rna.urmc.rochester.edu/rnastructureweb/servers	https://rna.urmc.rochester.edu/rnastructureweb/servers	NOUN
biomedich-819	34	25	/maxexpect	/maxexpect	PUNCT
biomedich-819	34	26	/	/	SYM
biomedich-819	34	27	maxexpect.html	maxexpect.html	PROPN
biomedich-819	34	28	.	.	PUNCT
biomedich-819	35	1	subsequently	subsequently	ADV
biomedich-819	35	2	,	,	PUNCT
biomedich-819	35	3	the	the	DET
biomedich-819	35	4	21nt	21nt	ADJ
biomedich-819	35	5	guide	guide	NOUN
biomedich-819	35	6	rna	rna	NOUN
biomedich-819	35	7	oligo	oligo	ADJ
biomedich-819	35	8	sequences	sequence	NOUN
biomedich-819	35	9	(	(	PUNCT
biomedich-819	35	10	5′→3′	5′→3′	NOUN
biomedich-819	35	11	)	)	PUNCT
biomedich-819	35	12	obtained	obtain	VERB
biomedich-819	35	13	from	from	ADP
biomedich-819	35	14	sirna	sirna	PROPN
biomedich-819	35	15	design	design	NOUN
biomedich-819	35	16	analysis	analysis	NOUN
biomedich-819	35	17	using	use	VERB
biomedich-819	35	18	sidirect	sidirect	NOUN
biomedich-819	35	19	were	be	AUX
biomedich-819	35	20	submitted	submit	VERB
biomedich-819	35	21	.	.	PUNCT
biomedich-819	36	1	analysis	analysis	NOUN
biomedich-819	36	2	of	of	ADP
biomedich-819	36	3	the	the	DET
biomedich-819	36	4	binding	bind	VERB
biomedich-819	36	5	energy	energy	NOUN
biomedich-819	36	6	between	between	ADP
biomedich-819	36	7	sirna	sirna	PROPN
biomedich-819	36	8	and	and	CCONJ
biomedich-819	36	9	its	its	PRON
biomedich-819	36	10	target	target	NOUN
biomedich-819	36	11	mrna	mrna	NOUN
biomedich-819	36	12	analysis	analysis	NOUN
biomedich-819	36	13	of	of	ADP
biomedich-819	36	14	the	the	DET
biomedich-819	36	15	binding	bind	VERB
biomedich-819	36	16	energy	energy	NOUN
biomedich-819	36	17	between	between	ADP
biomedich-819	36	18	sirna	sirna	PROPN
biomedich-819	36	19	and	and	CCONJ
biomedich-819	36	20	the	the	DET
biomedich-819	36	21	s.	s.	PROPN
biomedich-819	36	22	aureus	aureus	PROPN
biomedich-819	36	23	icad	icad	PROPN
biomedich-819	36	24	gene	gene	NOUN
biomedich-819	36	25	target	target	NOUN
biomedich-819	36	26	was	be	AUX
biomedich-819	36	27	done	do	VERB
biomedich-819	36	28	using	use	VERB
biomedich-819	36	29	duplexfold	duplexfold	NOUN
biomedich-819	36	30	(	(	PUNCT
biomedich-819	36	31	https://rna.urmc.rochester.edu/rnastructureweb/server	https://rna.urmc.rochester.edu/rnastructureweb/server	NOUN
biomedich-819	36	32	s	s	PROPN
biomedich-819	36	33	/	/	SYM
biomedich-819	36	34	duplexfold	duplexfold	ADJ
biomedich-819	36	35	/	/	SYM
biomedich-819	36	36	duplexfold.html	duplexfold.html	NOUN
biomedich-819	36	37	)	)	PUNCT
biomedich-819	36	38	.	.	PUNCT
biomedich-819	37	1	the	the	DET
biomedich-819	37	2	software	software	NOUN
biomedich-819	37	3	showed	show	VERB
biomedich-819	37	4	the	the	DET
biomedich-819	37	5	analysis	analysis	NOUN
biomedich-819	37	6	results	result	NOUN
biomedich-819	37	7	,	,	PUNCT
biomedich-819	37	8	including	include	VERB
biomedich-819	37	9	the	the	DET
biomedich-819	37	10	binding	bind	VERB
biomedich-819	37	11	energy	energy	NOUN
biomedich-819	37	12	and	and	CCONJ
biomedich-819	37	13	a	a	DET
biomedich-819	37	14	predicted	predict	VERB
biomedich-819	37	15	secondary	secondary	ADJ
biomedich-819	37	16	rna	rna	NOUN
biomedich-819	37	17	structure	structure	NOUN
biomedich-819	37	18	diagram	diagram	NOUN
biomedich-819	37	19	.	.	PUNCT
biomedich-819	38	1	efficacy	efficacy	NOUN
biomedich-819	38	2	prediction	prediction	NOUN
biomedich-819	38	3	of	of	ADP
biomedich-819	38	4	sirna	sirna	PROPN
biomedich-819	38	5	molecules	molecule	NOUN
biomedich-819	38	6	prediction	prediction	NOUN
biomedich-819	38	7	of	of	ADP
biomedich-819	38	8	sirna	sirna	PROPN
biomedich-819	38	9	efficacy	efficacy	PROPN
biomedich-819	38	10	against	against	ADP
biomedich-819	38	11	the	the	DET
biomedich-819	38	12	icad	icad	PROPN
biomedich-819	38	13	target	target	NOUN
biomedich-819	38	14	in	in	ADP
biomedich-819	38	15	s.	s.	PROPN
biomedich-819	38	16	aureus	aureus	PROPN
biomedich-819	38	17	was	be	AUX
biomedich-819	38	18	performed	perform	VERB
biomedich-819	38	19	using	use	VERB
biomedich-819	38	20	sipred	sipre	VERB
biomedich-819	38	21	(	(	PUNCT
biomedich-819	38	22	http://predictor.nchu.edu.tw/sipred/	http://predictor.nchu.edu.tw/sipred/	PROPN
biomedich-819	38	23	)	)	PUNCT
biomedich-819	38	24	,	,	PUNCT
biomedich-819	38	25	then	then	ADV
biomedich-819	38	26	the	the	DET
biomedich-819	38	27	software	software	NOUN
biomedich-819	38	28	displayed	display	VERB
biomedich-819	38	29	predicted	predict	VERB
biomedich-819	38	30	position	position	NOUN
biomedich-819	38	31	and	and	CCONJ
biomedich-819	38	32	inhibitory	inhibitory	ADJ
biomedich-819	38	33	effects	effect	NOUN
biomedich-819	38	34	of	of	ADP
biomedich-819	38	35	the	the	DET
biomedich-819	38	36	sirna	sirna	PROPN
biomedich-819	38	37	strand	strand	NOUN
biomedich-819	38	38	on	on	ADP
biomedich-819	38	39	the	the	DET
biomedich-819	38	40	icad	icad	PROPN
biomedich-819	38	41	gene	gene	NOUN
biomedich-819	38	42	.	.	PUNCT
biomedich-819	39	1	results	result	NOUN
biomedich-819	39	2	and	and	CCONJ
biomedich-819	39	3	discussion	discussion	NOUN
biomedich-819	39	4	results	result	NOUN
biomedich-819	39	5	and	and	CCONJ
biomedich-819	39	6	discussion	discussion	NOUN
biomedich-819	39	7	should	should	AUX
biomedich-819	39	8	be	be	AUX
biomedich-819	39	9	written	write	VERB
biomedich-819	39	10	as	as	ADP
biomedich-819	39	11	a	a	DET
biomedich-819	39	12	series	series	NOUN
biomedich-819	39	13	of	of	ADP
biomedich-819	39	14	connecting	connect	VERB
biomedich-819	39	15	sentences	sentence	NOUN
biomedich-819	39	16	,	,	PUNCT
biomedich-819	39	17	however	however	ADV
biomedich-819	39	18	,	,	PUNCT
biomedich-819	39	19	for	for	SCONJ
biomedich-819	39	20	manuscript	manuscript	NOUN
biomedich-819	39	21	with	with	ADP
biomedich-819	39	22	long	long	ADJ
biomedich-819	39	23	discussion	discussion	NOUN
biomedich-819	39	24	should	should	AUX
biomedich-819	39	25	be	be	AUX
biomedich-819	39	26	divided	divide	VERB
biomedich-819	39	27	into	into	ADP
biomedich-819	39	28	subtitles	subtitle	NOUN
biomedich-819	39	29	.	.	PUNCT
biomedich-819	40	1	results	result	NOUN
biomedich-819	40	2	should	should	AUX
biomedich-819	40	3	be	be	AUX
biomedich-819	40	4	clear	clear	ADJ
biomedich-819	40	5	and	and	CCONJ
biomedich-819	40	6	concise	concise	ADJ
biomedich-819	40	7	.	.	PUNCT
biomedich-819	41	1	result	result	NOUN
biomedich-819	41	2	of	of	ADP
biomedich-819	41	3	the	the	DET
biomedich-819	41	4	e	e	PROPN
biomedich-819	41	5	xploration	xploration	NOUN
biomedich-819	41	6	of	of	ADP
biomedich-819	41	7	sirna	sirna	PROPN
biomedich-819	41	8	targeting	target	VERB
biomedich-819	41	9	the	the	DET
biomedich-819	41	10	icad	icad	ADJ
biomedich-819	41	11	antigen	antigen	NOUN
biomedich-819	41	12	of	of	ADP
biomedich-819	41	13	staphylococcus	staphylococcus	NOUN
biomedich-819	41	14	aureus	aureus	NOUN
biomedich-819	41	15	fifty	fifty	NUM
biomedich-819	41	16	-	-	PUNCT
biomedich-819	41	17	four	four	NUM
biomedich-819	41	18	sirna	sirna	PROPN
biomedich-819	41	19	candidates	candidate	NOUN
biomedich-819	41	20	were	be	AUX
biomedich-819	41	21	successfully	successfully	ADV
biomedich-819	41	22	designed	design	VERB
biomedich-819	41	23	based	base	VERB
biomedich-819	41	24	on	on	ADP
biomedich-819	41	25	the	the	DET
biomedich-819	41	26	complete	complete	ADJ
biomedich-819	41	27	genome	genome	NOUN
biomedich-819	41	28	of	of	ADP
biomedich-819	41	29	the	the	DET
biomedich-819	41	30	icad	icad	PROPN
biomedich-819	41	31	gene	gene	NOUN
biomedich-819	41	32	from	from	ADP
biomedich-819	41	33	s.	s.	PROPN
biomedich-819	41	34	aureus	aureus	PROPN
biomedich-819	41	35	(	(	PUNCT
biomedich-819	41	36	ncbi	ncbi	PROPN
biomedich-819	41	37	accession	accession	NOUN
biomedich-819	41	38	number	number	NOUN
biomedich-819	41	39	:	:	PUNCT
biomedich-819	41	40	cp140612.1	cp140612.1	X
biomedich-819	41	41	)	)	PUNCT
biomedich-819	41	42	.	.	PUNCT
biomedich-819	42	1	the	the	DET
biomedich-819	42	2	analysis	analysis	NOUN
biomedich-819	42	3	of	of	ADP
biomedich-819	42	4	target	target	NOUN
biomedich-819	42	5	locations	location	NOUN
biomedich-819	42	6	,	,	PUNCT
biomedich-819	42	7	target	target	NOUN
biomedich-819	42	8	region	region	NOUN
biomedich-819	42	9	length	length	NOUN
biomedich-819	42	10	,	,	PUNCT
biomedich-819	42	11	binding	binding	ADJ
biomedich-819	42	12	,	,	PUNCT
biomedich-819	42	13	and	and	CCONJ
biomedich-819	42	14	inhibition	inhibition	NOUN
biomedich-819	42	15	of	of	ADP
biomedich-819	42	16	the	the	DET
biomedich-819	42	17	antigen	antigen	ADJ
biomedich-819	42	18	sequences	sequence	NOUN
biomedich-819	42	19	in	in	ADP
biomedich-819	42	20	these	these	DET
biomedich-819	42	21	fifty	fifty	NUM
biomedich-819	42	22	-	-	PUNCT
biomedich-819	42	23	four	four	NUM
biomedich-819	42	24	sirna	sirna	PROPN
biomedich-819	42	25	candidates	candidate	NOUN
biomedich-819	42	26	targeting	target	VERB
biomedich-819	42	27	the	the	DET
biomedich-819	42	28	icad	icad	ADJ
biomedich-819	42	29	antigen	antigen	NOUN
biomedich-819	42	30	of	of	ADP
biomedich-819	42	31	staphylococcus	staphylococcus	NOUN
biomedich-819	42	32	aureus	aureus	PROPN
biomedich-819	42	33	resulted	result	VERB
biomedich-819	42	34	in	in	ADP
biomedich-819	42	35	data	datum	NOUN
biomedich-819	42	36	as	as	SCONJ
biomedich-819	42	37	shown	show	VERB
biomedich-819	42	38	in	in	ADP
biomedich-819	42	39	table	table	NOUN
biomedich-819	42	40	1	1	NUM
biomedich-819	42	41	below	below	ADV
biomedich-819	42	42	.	.	PUNCT
biomedich-819	43	1	table	table	NOUN
biomedich-819	43	2	1	1	NUM
biomedich-819	43	3	.	.	PUNCT
biomedich-819	44	1	the	the	DET
biomedich-819	44	2	analysis	analysis	NOUN
biomedich-819	44	3	of	of	ADP
biomedich-819	44	4	target	target	NOUN
biomedich-819	44	5	sirna	sirna	PROPN
biomedich-819	44	6	.	.	PUNCT
biomedich-819	45	1	no	no	DET
biomedich-819	45	2	target	target	NOUN
biomedich-819	45	3	position	position	NOUN
biomedich-819	45	4	rna	rna	NOUN
biomedich-819	45	5	oligo	oligo	ADJ
biomedich-819	45	6	sequences	sequence	NOUN
biomedich-819	45	7	21nt	21nt	NOUN
biomedich-819	45	8	guide	guide	NOUN
biomedich-819	45	9	(	(	PUNCT
biomedich-819	45	10	5′→3′	5′→3′	NOUN
biomedich-819	45	11	)	)	PUNCT
biomedich-819	45	12	rna	rna	NOUN
biomedich-819	45	13	oligo	oligo	ADJ
biomedich-819	45	14	sequences	sequence	NOUN
biomedich-819	45	15	21nt	21nt	NOUN
biomedich-819	45	16	passenger	passenger	NOUN
biomedich-819	45	17	(	(	PUNCT
biomedich-819	45	18	5′→3′	5′→3′	NOUN
biomedich-819	45	19	)	)	PUNCT
biomedich-819	45	20	sirna	sirna	PROPN
biomedich-819	45	21	scales	scale	VERB
biomedich-819	45	22	max	max	PROPN
biomedich-819	45	23	expect	expect	VERB
biomedich-819	45	24	duplex	duplex	NOUN
biomedich-819	45	25	fold	fold	PROPN
biomedich-819	45	26	sirna	sirna	PROPN
biomedich-819	45	27	efficacy	efficacy	PROPN
biomedich-819	45	28	1	1	NUM
biomedich-819	45	29	10	10	NUM
biomedich-819	45	30	-	-	SYM
biomedich-819	45	31	32	32	NUM
biomedich-819	45	32	uggguauucccucugucuggg	uggguauucccucugucuggg	NOUN
biomedich-819	45	33	cagacagagggaauacccaac	cagacagagggaauacccaac	NOUN
biomedich-819	45	34	14	14	NUM
biomedich-819	45	35	1.4	1.4	NUM
biomedich-819	46	1	-38.2	-38.2	NUM
biomedich-819	46	2	74.17	74.17	NUM
biomedich-819	46	3	2	2	NUM
biomedich-819	46	4	16	16	NUM
biomedich-819	46	5	-	-	SYM
biomedich-819	46	6	38	38	NUM
biomedich-819	46	7	uagcguuggguauucccucug	uagcguuggguauucccucug	ADJ
biomedich-819	46	8	gagggaauacccaacgcuaaa	gagggaauacccaacgcuaaa	NOUN
biomedich-819	46	9	7	7	NUM
biomedich-819	46	10	1.9	1.9	NUM
biomedich-819	46	11	-37.4	-37.4	NUM
biomedich-819	46	12	74.54	74.54	NUM
biomedich-819	46	13	3	3	NUM
biomedich-819	46	14	18	18	NUM
biomedich-819	46	15	-	-	SYM
biomedich-819	46	16	40	40	NUM
biomedich-819	46	17	uuuagcguuggguauucccuc	uuuagcguuggguauucccuc	NOUN
biomedich-819	46	18	gggaauacccaacgcuaaaau	gggaauacccaacgcuaaaau	ADJ
biomedich-819	46	19	11	11	NUM
biomedich-819	46	20	2.0	2.0	NUM
biomedich-819	46	21	-34.7	-34.7	NOUN
biomedich-819	46	22	none	none	NOUN
biomedich-819	46	23	4	4	NUM
biomedich-819	46	24	19	19	NUM
biomedich-819	46	25	-	-	PUNCT
biomedich-819	46	26	41	41	NUM
biomedich-819	46	27	uuuuagcguuggguauucccu	uuuuagcguuggguauucccu	ADJ
biomedich-819	46	28	ggaauacccaacgcuaaaauc	ggaauacccaacgcuaaaauc	NOUN
biomedich-819	46	29	11	11	NUM
biomedich-819	46	30	2.0	2.0	NUM
biomedich-819	46	31	-31.7	-31.7	ADV
biomedich-819	46	32	none	none	NOUN
biomedich-819	46	33	5	5	NUM
biomedich-819	46	34	20	20	NUM
biomedich-819	46	35	-	-	SYM
biomedich-819	46	36	42	42	NUM
biomedich-819	46	37	auuuuagcguuggguauuccc	auuuuagcguuggguauuccc	NOUN
biomedich-819	46	38	gaauacccaacgcuaaaauca	gaauacccaacgcuaaaauca	NOUN
biomedich-819	46	39	25	25	NUM
biomedich-819	46	40	1.8	1.8	NUM
biomedich-819	46	41	-29.0	-29.0	NOUN
biomedich-819	46	42	none	none	NOUN
biomedich-819	46	43	6	6	NUM
biomedich-819	46	44	30	30	NUM
biomedich-819	46	45	-	-	SYM
biomedich-819	46	46	52	52	NUM
biomedich-819	46	47	uuuagcgaugauuuuagcguu	uuuagcgaugauuuuagcguu	ADJ
biomedich-819	46	48	cgcuaaaaucaucgcuaaaca	cgcuaaaaucaucgcuaaaca	NOUN
biomedich-819	46	49	6	6	NUM
biomedich-819	46	50	1.5	1.5	NUM
biomedich-819	46	51	-28.5	-28.5	NUM
biomedich-819	46	52	75.9	75.9	NUM
biomedich-819	46	53	7	7	NUM
biomedich-819	46	54	32	32	NUM
biomedich-819	46	55	-	-	SYM
biomedich-819	46	56	54	54	NUM
biomedich-819	46	57	uguuuagcgaugauuuuagcg	uguuuagcgaugauuuuagcg	ADJ
biomedich-819	46	58	cuaaaaucaucgcuaaacauu	cuaaaaucaucgcuaaacauu	PROPN
biomedich-819	46	59	17	17	NUM
biomedich-819	46	60	1.9	1.9	NUM
biomedich-819	46	61	-26.9	-26.9	NUM
biomedich-819	46	62	70.01	70.01	NUM
biomedich-819	46	63	8	8	NUM
biomedich-819	46	64	42	42	NUM
biomedich-819	46	65	-	-	SYM
biomedich-819	46	66	64	64	NUM
biomedich-819	46	67	ucucuuauaauguuuagcgau	ucucuuauaauguuuagcgau	NOUN
biomedich-819	46	68	cgcuaaacauuauaagagaaa	cgcuaaacauuauaagagaaa	NOUN
biomedich-819	46	69	10	10	NUM
biomedich-819	46	70	1.6	1.6	NUM
biomedich-819	46	71	-28.2	-28.2	NUM
biomedich-819	46	72	85.79	85.79	NUM
biomedich-819	46	73	9	9	NUM
biomedich-819	46	74	43	43	NUM
biomedich-819	46	75	-	-	SYM
biomedich-819	46	76	65	65	NUM
biomedich-819	46	77	uucucuuauaauguuuagcga	uucucuuauaauguuuagcga	ADJ
biomedich-819	46	78	gcuaaacauuauaagagaaac	gcuaaacauuauaagagaaac	NOUN
biomedich-819	46	79	2	2	NUM
biomedich-819	46	80	1.7	1.7	NUM
biomedich-819	46	81	-27.3	-27.3	PROPN
biomedich-819	46	82	85.79	85.79	NUM
biomedich-819	46	83	10	10	NUM
biomedich-819	46	84	44	44	NUM
biomedich-819	46	85	-	-	SYM
biomedich-819	46	86	66	66	NUM
biomedich-819	46	87	uuucucuuauaauguuuagcg	uuucucuuauaauguuuagcg	NOUN
biomedich-819	46	88	cuaaacauuauaagagaaaca	cuaaacauuauaagagaaaca	NOUN
biomedich-819	46	89	14	14	NUM
biomedich-819	46	90	1.8	1.8	NUM
biomedich-819	46	91	-23.2	-23.2	NOUN
biomedich-819	46	92	none	none	NOUN
biomedich-819	46	93	11	11	NUM
biomedich-819	46	94	49	49	NUM
biomedich-819	46	95	-	-	SYM
biomedich-819	46	96	71	71	NUM
biomedich-819	46	97	ugcuguuucucuuauaauguu	ugcuguuucucuuauaauguu	NOUN
biomedich-819	46	98	cauuauaagagaaacagcacu	cauuauaagagaaacagcacu	NOUN
biomedich-819	46	99	12	12	NUM
biomedich-819	46	100	1.7	1.7	NUM
biomedich-819	46	101	-27.9	-27.9	NUM
biomedich-819	46	102	86.47	86.47	NUM
biomedich-819	46	103	12	12	NUM
biomedich-819	46	104	59	59	NUM
biomedich-819	46	105	-	-	SYM
biomedich-819	46	106	81	81	NUM
biomedich-819	46	107	uagcgauaagugcuguuucuc	uagcgauaagugcuguuucuc	NOUN
biomedich-819	46	108	gaaacagcacuuaucgcuaua	gaaacagcacuuaucgcuaua	NOUN
biomedich-819	46	109	8	8	NUM
biomedich-819	46	110	1.9	1.9	NUM
biomedich-819	46	111	-32.5	-32.5	NUM
biomedich-819	46	112	82.54	82.54	NUM
biomedich-819	46	113	13	13	NUM
biomedich-819	46	114	65	65	NUM
biomedich-819	46	115	-	-	SYM
biomedich-819	46	116	87	87	NUM
biomedich-819	46	117	acgauauagcgauaagugcug	acgauauagcgauaagugcug	NOUN
biomedich-819	46	118	gcacuuaucgcuauaucgugu	gcacuuaucgcuauaucgugu	ADP
biomedich-819	46	119	14	14	NUM
biomedich-819	46	120	1.9	1.9	NUM
biomedich-819	46	121	-32.5	-32.5	NUM
biomedich-819	46	122	80.71	80.71	NUM
biomedich-819	46	123	14	14	NUM
biomedich-819	46	124	73	73	NUM
biomedich-819	46	125	-	-	SYM
biomedich-819	46	126	95	95	NUM
biomedich-819	46	127	aaagacacacgauauagcgau	aaagacacacgauauagcgau	NOUN
biomedich-819	46	128	cgcuauaucgugugucuuuug	cgcuauaucgugugucuuuug	PROPN
biomedich-819	46	129	14	14	NUM
biomedich-819	46	130	1.9	1.9	NUM
biomedich-819	47	1	-31.2	-31.2	NUM
biomedich-819	47	2	83.94	83.94	NUM
biomedich-819	47	3	15	15	NUM
biomedich-819	47	4	74	74	NUM
biomedich-819	47	5	-	-	SYM
biomedich-819	47	6	96	96	NUM
biomedich-819	47	7	aaaagacacacgauauagcga	aaaagacacacgauauagcga	NOUN
biomedich-819	47	8	gcuauaucgugugucuuuugg	gcuauaucgugugucuuuugg	NOUN
biomedich-819	47	9	9	9	NUM
biomedich-819	47	10	1.9	1.9	NUM
biomedich-819	47	11	-30.9	-30.9	NUM
biomedich-819	47	12	83.94	83.94	NUM
biomedich-819	47	13	16	16	NUM
biomedich-819	47	14	81	81	NUM
biomedich-819	47	15	-	-	SYM
biomedich-819	47	16	103	103	NUM
biomedich-819	47	17	uauauccaaaagacacacgau	uauauccaaaagacacacgau	NOUN
biomedich-819	47	18	cgugugucuuuuggauauauu	cgugugucuuuuggauauauu	NOUN
biomedich-819	47	19	5	5	NUM
biomedich-819	47	20	1.8	1.8	NUM
biomedich-819	47	21	-30.1	-30.1	NUM
biomedich-819	47	22	80.02	80.02	NUM
biomedich-819	47	23	17	17	NUM
biomedich-819	47	24	82	82	NUM
biomedich-819	47	25	-	-	SYM
biomedich-819	47	26	104	104	NUM
biomedich-819	47	27	auauauccaaaagacacacga	auauauccaaaagacacacga	PROPN
biomedich-819	47	28	gugugucuuuuggauauauug	gugugucuuuuggauauauug	PROPN
biomedich-819	47	29	14	14	NUM
biomedich-819	47	30	1.8	1.8	NUM
biomedich-819	47	31	-28.9	-28.9	SYM
biomedich-819	47	32	80.02	80.02	NUM
biomedich-819	47	33	18	18	NUM
biomedich-819	47	34	86	86	NUM
biomedich-819	47	35	-	-	SYM
biomedich-819	47	36	108	108	NUM
biomedich-819	47	37	aacaauauauccaaaagacac	aacaauauauccaaaagacac	PROPN
biomedich-819	47	38	gucuuuuggauauauuguuua	gucuuuuggauauauuguuua	ADJ
biomedich-819	47	39	26	26	NUM
biomedich-819	47	40	1.9	1.9	NUM
biomedich-819	47	41	-26.4	-26.4	NUM
biomedich-819	47	42	87.55	87.55	NUM
biomedich-819	47	43	19	19	NUM
biomedich-819	47	44	88	88	NUM
biomedich-819	47	45	-	-	SYM
biomedich-819	47	46	110	110	NUM
biomedich-819	47	47	uaaacaauauauccaaaagac	uaaacaauauauccaaaagac	NOUN
biomedich-819	47	48	cuuuuggauauauuguuuagu	cuuuuggauauauuguuuagu	NOUN
biomedich-819	47	49	15	15	NUM
biomedich-819	47	50	1.9	1.9	NUM
biomedich-819	47	51	-24.1	-24.1	NUM
biomedich-819	47	52	80.08	80.08	NUM
biomedich-819	47	53	20	20	NUM
biomedich-819	47	54	93	93	NUM
biomedich-819	47	55	-	-	SYM
biomedich-819	47	56	115	115	NUM
biomedich-819	47	57	acaacuaaacaauauauccaa	acaacuaaacaauauauccaa	NOUN
biomedich-819	47	58	ggauauauuguuuaguuguuc	ggauauauuguuuaguuguuc	PROPN
biomedich-819	47	59	19	19	NUM
biomedich-819	47	60	1.8	1.8	NUM
biomedich-819	47	61	-26.6	-26.6	PROPN
biomedich-819	47	62	85.78	85.78	NUM
biomedich-819	47	63	21	21	NUM
biomedich-819	47	64	94	94	NUM
biomedich-819	47	65	-	-	SYM
biomedich-819	47	66	116	116	NUM
biomedich-819	47	67	aacaacuaaacaauauaucca	aacaacuaaacaauauaucca	PROPN
biomedich-819	47	68	gauauauuguuuaguuguucu	gauauauuguuuaguuguucu	NOUN
biomedich-819	47	69	11	11	NUM
biomedich-819	47	70	1.8	1.8	NUM
biomedich-819	47	71	-23.3	-23.3	NOUN
biomedich-819	47	72	84.44	84.44	NUM
biomedich-819	47	73	22	22	NUM
biomedich-819	47	74	102	102	NUM
biomedich-819	47	75	-	-	SYM
biomedich-819	47	76	124	124	NUM
biomedich-819	47	77	acgaguagaacaacuaaacaa	acgaguagaacaacuaaacaa	NOUN
biomedich-819	47	78	guuuaguuguucuacucguuu	guuuaguuguucuacucguuu	VERB
biomedich-819	47	79	20	20	NUM
biomedich-819	47	80	1.7	1.7	NUM
biomedich-819	47	81	-30.0	-30.0	NOUN
biomedich-819	47	82	93.69	93.69	NUM
biomedich-819	47	83	23	23	NUM
biomedich-819	47	84	107	107	NUM
biomedich-819	47	85	-	-	SYM
biomedich-819	47	86	129	129	NUM
biomedich-819	47	87	uauaaacgaguagaacaacua	uauaaacgaguagaacaacua	NOUN
biomedich-819	47	88	guuguucuacucguuuauauu	guuguucuacucguuuauauu	NOUN
biomedich-819	47	89	12	12	NUM
biomedich-819	47	90	1.8	1.8	NUM
biomedich-819	47	91	-28.1	-28.1	NUM
biomedich-819	47	92	83.92	83.92	NUM
biomedich-819	47	93	http://sidirect2.rnai.jp/	http://sidirect2.rnai.jp/	PROPN
biomedich-819	47	94	http://gesteland.genetics.utah.edu/sirna_scales/	http://gesteland.genetics.utah.edu/sirna_scales/	PROPN
biomedich-819	47	95	https://rna.urmc.rochester.edu/rnastructureweb/servers/maxexpect/maxexpect.html	https://rna.urmc.rochester.edu/rnastructureweb/servers/maxexpect/maxexpect.html	VERB
biomedich-819	47	96	https://rna.urmc.rochester.edu/rnastructureweb/servers/maxexpect/maxexpect.html	https://rna.urmc.rochester.edu/rnastructureweb/servers/maxexpect/maxexpect.html	VERB
biomedich-819	47	97	https://rna.urmc.rochester.edu/rnastructureweb/servers/duplexfold/duplexfold.html	https://rna.urmc.rochester.edu/rnastructureweb/servers/duplexfold/duplexfold.html	PROPN
biomedich-819	47	98	https://rna.urmc.rochester.edu/rnastructureweb/servers/duplexfold/duplexfold.html	https://rna.urmc.rochester.edu/rnastructureweb/servers/duplexfold/duplexfold.html	PROPN
biomedich-819	48	1	http://predictor.nchu.edu.tw/sipred/	http://predictor.nchu.edu.tw/sipred/	PROPN
biomedich-819	48	2	sulistina	sulistina	PROPN
biomedich-819	48	3	et	et	PROPN
biomedich-819	48	4	al	al	PROPN
biomedich-819	48	5	.	.	PROPN
biomedich-819	48	6	–	–	PUNCT
biomedich-819	48	7	sirnas	sirna	NOUN
biomedich-819	48	8	targeting	target	VERB
biomedich-819	48	9	icad	icad	ADJ
biomedich-819	48	10	gene	gene	NOUN
biomedich-819	48	11	of	of	ADP
biomedich-819	48	12	staphylococcus	staphylococcus	NOUN
biomedich-819	48	13	aureus	aureus	NOUN
biomedich-819	48	14	to	to	PART
biomedich-819	48	15	inhibit	inhibit	VERB
biomedich-819	48	16	biofilm	biofilm	NOUN
biomedich-819	48	17	923	923	NUM
biomedich-819	48	18	no	no	DET
biomedich-819	48	19	target	target	NOUN
biomedich-819	48	20	position	position	NOUN
biomedich-819	48	21	rna	rna	NOUN
biomedich-819	48	22	oligo	oligo	ADJ
biomedich-819	48	23	sequences	sequence	NOUN
biomedich-819	48	24	21nt	21nt	NOUN
biomedich-819	48	25	guide	guide	NOUN
biomedich-819	48	26	(	(	PUNCT
biomedich-819	48	27	5′→3′	5′→3′	NOUN
biomedich-819	48	28	)	)	PUNCT
biomedich-819	48	29	rna	rna	NOUN
biomedich-819	48	30	oligo	oligo	ADJ
biomedich-819	48	31	sequences	sequence	NOUN
biomedich-819	48	32	21nt	21nt	NOUN
biomedich-819	48	33	passenger	passenger	NOUN
biomedich-819	48	34	(	(	PUNCT
biomedich-819	48	35	5′→3′	5′→3′	NOUN
biomedich-819	48	36	)	)	PUNCT
biomedich-819	48	37	sirna	sirna	PROPN
biomedich-819	48	38	scales	scale	VERB
biomedich-819	48	39	max	max	PROPN
biomedich-819	48	40	expect	expect	VERB
biomedich-819	48	41	duplex	duplex	NOUN
biomedich-819	48	42	fold	fold	PROPN
biomedich-819	48	43	sirna	sirna	PROPN
biomedich-819	48	44	efficacy	efficacy	PROPN
biomedich-819	48	45	24	24	NUM
biomedich-819	48	46	113	113	NUM
biomedich-819	48	47	-	-	SYM
biomedich-819	48	48	135	135	NUM
biomedich-819	48	49	uaccaauauaaacgaguagaa	uaccaauauaaacgaguagaa	NOUN
biomedich-819	48	50	cuacucguuuauauugguacu	cuacucguuuauauugguacu	NOUN
biomedich-819	48	51	16	16	NUM
biomedich-819	48	52	1.8	1.8	NUM
biomedich-819	48	53	-28.1	-28.1	NUM
biomedich-819	48	54	92.07	92.07	NUM
biomedich-819	48	55	25	25	NUM
biomedich-819	48	56	116	116	NUM
biomedich-819	48	57	-	-	SYM
biomedich-819	48	58	138	138	NUM
biomedich-819	48	59	uaguaccaauauaaacgagua	uaguaccaauauaaacgagua	ADJ
biomedich-819	48	60	cucguuuauauugguacuaua	cucguuuauauugguacuaua	NOUN
biomedich-819	48	61	15	15	NUM
biomedich-819	48	62	1.8	1.8	NUM
biomedich-819	49	1	-27.7	-27.7	NUM
biomedich-819	49	2	92.52	92.52	NUM
biomedich-819	49	3	26	26	NUM
biomedich-819	49	4	118	118	NUM
biomedich-819	49	5	-	-	SYM
biomedich-819	49	6	140	140	NUM
biomedich-819	49	7	uauaguaccaauauaaacgag	uauaguaccaauauaaacgag	NOUN
biomedich-819	49	8	cguuuauauugguacuauauu	cguuuauauugguacuauauu	NOUN
biomedich-819	49	9	-3	-3	PUNCT
biomedich-819	49	10	1.7	1.7	NUM
biomedich-819	49	11	-26.1	-26.1	NUM
biomedich-819	49	12	82.05	82.05	NUM
biomedich-819	49	13	27	27	NUM
biomedich-819	49	14	119	119	NUM
biomedich-819	49	15	-	-	SYM
biomedich-819	49	16	141	141	NUM
biomedich-819	49	17	auauaguaccaauauaaacga	auauaguaccaauauaaacga	NOUN
biomedich-819	49	18	guuuauauugguacuauauuu	guuuauauugguacuauauuu	VERB
biomedich-819	49	19	14	14	NUM
biomedich-819	49	20	1.6	1.6	NUM
biomedich-819	49	21	-24.9	-24.9	NUM
biomedich-819	49	22	82.05	82.05	NUM
biomedich-819	49	23	28	28	NUM
biomedich-819	49	24	129	129	NUM
biomedich-819	49	25	-	-	SYM
biomedich-819	49	26	151	151	NUM
biomedich-819	49	27	ugaauuucaaauauaguacca	ugaauuucaaauauaguacca	ADJ
biomedich-819	49	28	guacuauauuugaaauucaug	guacuauauuugaaauucaug	NOUN
biomedich-819	49	29	15	15	NUM
biomedich-819	50	1	1.8	1.8	NUM
biomedich-819	50	2	-24.0	-24.0	NUM
biomedich-819	50	3	77.03	77.03	NUM
biomedich-819	50	4	29	29	NUM
biomedich-819	50	5	132	132	NUM
biomedich-819	50	6	-	-	SYM
biomedich-819	50	7	154	154	NUM
biomedich-819	50	8	ucaugaauuucaaauauagua	ucaugaauuucaaauauagua	PROPN
biomedich-819	50	9	cuauauuugaaauucaugacg	cuauauuugaaauucaugacg	NOUN
biomedich-819	50	10	16	16	NUM
biomedich-819	50	11	1.8	1.8	NUM
biomedich-819	50	12	-23.6	-23.6	NUM
biomedich-819	50	13	85.43	85.43	NUM
biomedich-819	50	14	30	30	NUM
biomedich-819	50	15	140	140	NUM
biomedich-819	50	16	-	-	SYM
biomedich-819	50	17	162	162	NUM
biomedich-819	50	18	uacuuucgucaugaauuucaa	uacuuucgucaugaauuucaa	ADJ
biomedich-819	50	19	gaaauucaugacgaaaguauc	gaaauucaugacgaaaguauc	NOUN
biomedich-819	50	20	14	14	NUM
biomedich-819	50	21	1.6	1.6	NUM
biomedich-819	50	22	-28.4	-28.4	NOUN
biomedich-819	50	23	91.93	91.93	NUM
biomedich-819	50	24	31	31	NUM
biomedich-819	50	25	146	146	NUM
biomedich-819	50	26	-	-	SYM
biomedich-819	50	27	168	168	NUM
biomedich-819	50	28	uauugauacuuucgucaugaa	uauugauacuuucgucaugaa	NOUN
biomedich-819	50	29	caugacgaaaguaucaauaca	caugacgaaaguaucaauaca	NUM
biomedich-819	50	30	12	12	NUM
biomedich-819	50	31	1.8	1.8	NUM
biomedich-819	50	32	-28.0	-28.0	NUM
biomedich-819	50	33	82.7	82.7	NUM
biomedich-819	50	34	32	32	NUM
biomedich-819	50	35	149	149	NUM
biomedich-819	50	36	-	-	SYM
biomedich-819	50	37	171	171	NUM
biomedich-819	50	38	uuguauugauacuuucgucau	uuguauugauacuuucgucau	NOUN
biomedich-819	50	39	gacgaaaguaucaauacaaua	gacgaaaguaucaauacaaua	NOUN
biomedich-819	50	40	8	8	NUM
biomedich-819	50	41	1.8	1.8	NUM
biomedich-819	50	42	-28.6	-28.6	NUM
biomedich-819	50	43	88.71	88.71	NUM
biomedich-819	50	44	33	33	NUM
biomedich-819	50	45	151	151	NUM
biomedich-819	50	46	-	-	SYM
biomedich-819	50	47	173	173	NUM
biomedich-819	50	48	uauuguauugauacuuucguc	uauuguauugauacuuucguc	NOUN
biomedich-819	50	49	cgaaaguaucaauacaauacg	cgaaaguaucaauacaauacg	NOUN
biomedich-819	50	50	9	9	NUM
biomedich-819	50	51	1.6	1.6	NUM
biomedich-819	50	52	-25.2	-25.2	NUM
biomedich-819	50	53	none	none	NOUN
biomedich-819	50	54	34	34	NUM
biomedich-819	50	55	156	156	NUM
biomedich-819	50	56	-	-	SYM
biomedich-819	50	57	178	178	NUM
biomedich-819	50	58	acacguauuguauugauacuu	acacguauuguauugauacuu	NOUN
biomedich-819	50	59	guaucaauacaauacguguug	guaucaauacaauacguguug	NOUN
biomedich-819	50	60	23	23	NUM
biomedich-819	50	61	1.9	1.9	NUM
biomedich-819	50	62	-27.8	-27.8	NUM
biomedich-819	50	63	83.19	83.19	NUM
biomedich-819	50	64	35	35	NUM
biomedich-819	50	65	160	160	NUM
biomedich-819	50	66	-	-	SYM
biomedich-819	50	67	162	162	NUM
biomedich-819	50	68	agcaacacguauuguauugau	agcaacacguauuguauugau	NOUN
biomedich-819	50	69	caauacaauacguguugcuuu	caauacaauacguguugcuuu	VERB
biomedich-819	50	70	26	26	NUM
biomedich-819	50	71	1.4	1.4	NUM
biomedich-819	50	72	-29.2	-29.2	NOUN
biomedich-819	50	73	88.89	88.89	NUM
biomedich-819	50	74	36	36	NUM
biomedich-819	50	75	165	165	NUM
biomedich-819	50	76	-	-	SYM
biomedich-819	50	77	187	187	NUM
biomedich-819	50	78	uuuaaagcaacacguauugua	uuuaaagcaacacguauugua	NOUN
biomedich-819	50	79	caauacguguugcuuuaaaca	caauacguguugcuuuaaaca	NOUN
biomedich-819	50	80	5	5	NUM
biomedich-819	50	81	1.8	1.8	NUM
biomedich-819	50	82	-26.4	-26.4	NUM
biomedich-819	50	83	80.67	80.67	NUM
biomedich-819	50	84	37	37	NUM
biomedich-819	50	85	171	171	NUM
biomedich-819	50	86	-	-	SYM
biomedich-819	50	87	193	193	NUM
biomedich-819	50	88	ucaauguuuaaagcaacacgu	ucaauguuuaaagcaacacgu	ADJ
biomedich-819	50	89	guguugcuuuaaacauugaaa	guguugcuuuaaacauugaaa	NOUN
biomedich-819	50	90	9	9	NUM
biomedich-819	50	91	1.5	1.5	NUM
biomedich-819	50	92	-28.6	-28.6	NUM
biomedich-819	50	93	74.8	74.8	NUM
biomedich-819	50	94	38	38	NUM
biomedich-819	50	95	173	173	NUM
biomedich-819	50	96	-	-	SYM
biomedich-819	50	97	195	195	NUM
biomedich-819	50	98	uuucaauguuuaaagcaacac	uuucaauguuuaaagcaacac	ADJ
biomedich-819	50	99	guugcuuuaaacauugaaaau	guugcuuuaaacauugaaaau	NOUN
biomedich-819	50	100	17	17	NUM
biomedich-819	50	101	1.5	1.5	NUM
biomedich-819	50	102	-26.1	-26.1	PROPN
biomedich-819	50	103	73.85	73.85	NUM
biomedich-819	50	104	39	39	NUM
biomedich-819	50	105	176	176	NUM
biomedich-819	50	106	-	-	SYM
biomedich-819	50	107	198	198	NUM
biomedich-819	50	108	uauuuucaauguuuaaagcaa	uauuuucaauguuuaaagcaa	NOUN
biomedich-819	50	109	gcuuuaaacauugaaaauacu	gcuuuaaacauugaaaauacu	NOUN
biomedich-819	50	110	9	9	NUM
biomedich-819	50	111	1.8	1.8	NUM
biomedich-819	50	112	-23.9	-23.9	NUM
biomedich-819	50	113	84.08	84.08	NUM
biomedich-819	50	114	40	40	NUM
biomedich-819	50	115	184	184	NUM
biomedich-819	50	116	-	-	SYM
biomedich-819	50	117	206	206	NUM
biomedich-819	50	118	aauuucaguauuuucaauguu	aauuucaguauuuucaauguu	NOUN
biomedich-819	50	119	cauugaaaauacugaaauuuu	cauugaaaauacugaaauuuu	VERB
biomedich-819	50	120	6	6	NUM
biomedich-819	50	121	1.8	1.8	NUM
biomedich-819	50	122	-22.4	-22.4	NUM
biomedich-819	50	123	73.05	73.05	NUM
biomedich-819	50	124	41	41	NUM
biomedich-819	50	125	195	195	NUM
biomedich-819	50	126	-	-	SYM
biomedich-819	50	127	217	217	NUM
biomedich-819	50	128	aauauaucuaaaauuucagua	aauauaucuaaaauuucagua	NOUN
biomedich-819	50	129	cugaaauuuuagauauauuug	cugaaauuuuagauauauuug	NOUN
biomedich-819	50	130	17	17	NUM
biomedich-819	50	131	1.8	1.8	NUM
biomedich-819	50	132	-20.9	-20.9	NUM
biomedich-819	50	133	71.95	71.95	NUM
biomedich-819	50	134	42	42	NUM
biomedich-819	50	135	224	224	NUM
biomedich-819	50	136	-	-	SYM
biomedich-819	50	137	246	246	NUM
biomedich-819	50	138	ugauaaucgcgaaaaugccca	ugauaaucgcgaaaaugccca	ADJ
biomedich-819	50	139	ggcauuuucgcgauuaucauu	ggcauuuucgcgauuaucauu	NOUN
biomedich-819	50	140	16	16	NUM
biomedich-819	50	141	1.9	1.9	NUM
biomedich-819	50	142	-31.3	-31.3	NUM
biomedich-819	50	143	none	none	NOUN
biomedich-819	50	144	43	43	NUM
biomedich-819	50	145	225	225	NUM
biomedich-819	50	146	-	-	SYM
biomedich-819	50	147	247	247	NUM
biomedich-819	50	148	augauaaucgcgaaaaugccc	augauaaucgcgaaaaugccc	NOUN
biomedich-819	50	149	gcauuuucgcgauuaucauuu	gcauuuucgcgauuaucauuu	NOUN
biomedich-819	50	150	16	16	NUM
biomedich-819	50	151	1.9	1.9	NUM
biomedich-819	51	1	-28.6	-28.6	PUNCT
biomedich-819	51	2	none	none	NOUN
biomedich-819	51	3	44	44	NUM
biomedich-819	51	4	226	226	NUM
biomedich-819	51	5	-	-	SYM
biomedich-819	51	6	248	248	NUM
biomedich-819	51	7	aaugauaaucgcgaaaaugcc	aaugauaaucgcgaaaaugcc	NOUN
biomedich-819	51	8	cauuuucgcgauuaucauuuu	cauuuucgcgauuaucauuuu	NOUN
biomedich-819	51	9	18	18	NUM
biomedich-819	51	10	1.9	1.9	NUM
biomedich-819	51	11	-25.7	-25.7	NUM
biomedich-819	51	12	none	none	NOUN
biomedich-819	51	13	45	45	NUM
biomedich-819	51	14	232	232	NUM
biomedich-819	51	15	-	-	SYM
biomedich-819	51	16	254	254	NUM
biomedich-819	51	17	aacaaaaaugauaaucgcgaa	aacaaaaaugauaaucgcgaa	NOUN
biomedich-819	51	18	cgcgauuaucauuuuuguuuu	cgcgauuaucauuuuuguuuu	VERB
biomedich-819	51	19	18	18	NUM
biomedich-819	51	20	1.8	1.8	NUM
biomedich-819	51	21	-26.0	-26.0	NUM
biomedich-819	51	22	87.89	87.89	NUM
biomedich-819	51	23	46	46	NUM
biomedich-819	51	24	233	233	NUM
biomedich-819	51	25	-	-	SYM
biomedich-819	51	26	255	255	NUM
biomedich-819	51	27	aaacaaaaaugauaaucgcga	aaacaaaaaugauaaucgcga	NOUN
biomedich-819	51	28	gcgauuaucauuuuuguuuuu	gcgauuaucauuuuuguuuuu	NOUN
biomedich-819	51	29	12	12	NUM
biomedich-819	51	30	1.8	1.8	NUM
biomedich-819	51	31	-25.1	-25.1	NUM
biomedich-819	51	32	82.24	82.24	NUM
biomedich-819	51	33	47	47	NUM
biomedich-819	51	34	234	234	NUM
biomedich-819	51	35	-	-	SYM
biomedich-819	51	36	256	256	NUM
biomedich-819	51	37	aaaacaaaaaugauaaucgcg	aaaacaaaaaugauaaucgcg	NOUN
biomedich-819	51	38	cgauuaucauuuuuguuuuuu	cgauuaucauuuuuguuuuuu	NOUN
biomedich-819	51	39	4	4	NUM
biomedich-819	51	40	1.8	1.8	NUM
biomedich-819	52	1	-21.3	-21.3	NUM
biomedich-819	52	2	none	none	NOUN
biomedich-819	52	3	48	48	NUM
biomedich-819	52	4	235	235	NUM
biomedich-819	52	5	-	-	PUNCT
biomedich-819	52	6	257	257	NUM
biomedich-819	52	7	aaaaacaaaaaugauaaucgc	aaaaacaaaaaugauaaucgc	ADJ
biomedich-819	52	8	gauuaucauuuuuguuuuuuu	gauuaucauuuuuguuuuuuu	NOUN
biomedich-819	52	9	14	14	NUM
biomedich-819	52	10	1.8	1.8	NUM
biomedich-819	52	11	-21.1	-21.1	NUM
biomedich-819	52	12	none	none	NOUN
biomedich-819	52	13	49	49	NUM
biomedich-819	52	14	241	241	NUM
biomedich-819	52	15	-	-	SYM
biomedich-819	52	16	263	263	NUM
biomedich-819	52	17	uguaaaaaaaacaaaaaugau	uguaaaaaaaacaaaaaugau	NOUN
biomedich-819	52	18	cauuuuuguuuuuuuuacaau	cauuuuuguuuuuuuuacaau	NOUN
biomedich-819	52	19	14	14	NUM
biomedich-819	52	20	1.8	1.8	NUM
biomedich-819	52	21	-20.3	-20.3	NUM
biomedich-819	52	22	85.58	85.58	NUM
biomedich-819	52	23	50	50	NUM
biomedich-819	52	24	248	248	NUM
biomedich-819	52	25	-	-	SYM
biomedich-819	52	26	270	270	NUM
biomedich-819	52	27	ugcuaauuguaaaaaaaacaa	ugcuaauuguaaaaaaaacaa	NOUN
biomedich-819	52	28	guuuuuuuuacaauuagcaua	guuuuuuuuacaauuagcaua	NOUN
biomedich-819	52	29	21	21	NUM
biomedich-819	52	30	1.6	1.6	NUM
biomedich-819	52	31	-23.6	-23.6	NUM
biomedich-819	52	32	92.82	92.82	NUM
biomedich-819	52	33	51	51	NUM
biomedich-819	52	34	258	258	NUM
biomedich-819	52	35	-	-	SYM
biomedich-819	52	36	280	280	NUM
biomedich-819	52	37	ugaaucaauaugcuaauugua	ugaaucaauaugcuaauugua	ADJ
biomedich-819	52	38	caauuagcauauugauucaaa	caauuagcauauugauucaaa	NOUN
biomedich-819	52	39	5	5	NUM
biomedich-819	52	40	1.5	1.5	NUM
biomedich-819	52	41	-26.1	-26.1	NOUN
biomedich-819	52	42	84.7	84.7	NUM
biomedich-819	52	43	52	52	NUM
biomedich-819	52	44	271	271	NUM
biomedich-819	52	45	-	-	SYM
biomedich-819	52	46	293	293	NUM
biomedich-819	52	47	uuucugccauuuuugaaucaa	uuucugccauuuuugaaucaa	NOUN
biomedich-819	52	48	gauucaaaaauggcagaaagg	gauucaaaaauggcagaaagg	NOUN
biomedich-819	52	49	9	9	NUM
biomedich-819	52	50	1.7	1.7	NUM
biomedich-819	52	51	-28.7	-28.7	NUM
biomedich-819	52	52	79.92	79.92	NUM
biomedich-819	52	53	53	53	NUM
biomedich-819	52	54	275	275	NUM
biomedich-819	52	55	-	-	SYM
biomedich-819	52	56	297	297	NUM
biomedich-819	52	57	uuccuuucugccauuuuugaa	uuccuuucugccauuuuugaa	NOUN
biomedich-819	52	58	caaaaauggcagaaaggaaga	caaaaauggcagaaaggaaga	NOUN
biomedich-819	52	59	10	10	NUM
biomedich-819	52	60	1.8	1.8	NUM
biomedich-819	52	61	-30.0	-30.0	NUM
biomedich-819	52	62	87.94	87.94	NUM
biomedich-819	52	63	54	54	NUM
biomedich-819	52	64	284	284	NUM
biomedich-819	52	65	-	-	SYM
biomedich-819	52	66	306	306	NUM
biomedich-819	52	67	acgauucucuuccuuucugcc	acgauucucuuccuuucugcc	NOUN
biomedich-819	52	68	cagaaaggaagagaaucguga	cagaaaggaagagaaucguga	NOUN
biomedich-819	52	69	28	28	NUM
biomedich-819	52	70	1.8	1.8	NUM
biomedich-819	52	71	-31.6	-31.6	PRON
biomedich-819	52	72	71.35	71.35	NUM
biomedich-819	52	73	*	*	PUNCT
biomedich-819	52	74	top	top	ADJ
biomedich-819	52	75	3	3	NUM
biomedich-819	52	76	sirnas	sirna	NOUN
biomedich-819	52	77	with	with	ADP
biomedich-819	52	78	highest	high	ADJ
biomedich-819	52	79	efficacy	efficacy	NOUN
biomedich-819	52	80	was	be	AUX
biomedich-819	52	81	highlighted	highlight	VERB
biomedich-819	52	82	with	with	ADP
biomedich-819	52	83	bold	bold	ADJ
biomedich-819	52	84	font	font	NOUN
biomedich-819	52	85	.	.	PUNCT
biomedich-819	53	1	results	result	NOUN
biomedich-819	53	2	of	of	ADP
biomedich-819	53	3	the	the	DET
biomedich-819	53	4	structural	structural	ADJ
biomedich-819	53	5	analysis	analysis	NOUN
biomedich-819	53	6	of	of	ADP
biomedich-819	53	7	the	the	DET
biomedich-819	53	8	optimal	optimal	ADJ
biomedich-819	53	9	icad	icad	PROPN
biomedich-819	53	10	sirna	sirna	PROPN
biomedich-819	53	11	this	this	DET
biomedich-819	53	12	structure	structure	NOUN
biomedich-819	53	13	was	be	AUX
biomedich-819	53	14	selected	select	VERB
biomedich-819	53	15	based	base	VERB
biomedich-819	53	16	on	on	ADP
biomedich-819	53	17	the	the	DET
biomedich-819	53	18	parameters	parameter	NOUN
biomedich-819	53	19	of	of	ADP
biomedich-819	53	20	sirna	sirna	PROPN
biomedich-819	53	21	scales	scale	NOUN
biomedich-819	53	22	,	,	PUNCT
biomedich-819	53	23	maxexpert	maxexpert	ADJ
biomedich-819	53	24	,	,	PUNCT
biomedich-819	53	25	duplex	duplex	NOUN
biomedich-819	53	26	fold	fold	NOUN
biomedich-819	53	27	,	,	PUNCT
biomedich-819	53	28	and	and	CCONJ
biomedich-819	53	29	sirna	sirna	PROPN
biomedich-819	53	30	efficacy	efficacy	PROPN
biomedich-819	53	31	according	accord	VERB
biomedich-819	53	32	to	to	ADP
biomedich-819	53	33	the	the	DET
biomedich-819	53	34	optimal	optimal	ADJ
biomedich-819	53	35	criteria	criterion	NOUN
biomedich-819	53	36	.	.	PUNCT
biomedich-819	54	1	the	the	DET
biomedich-819	54	2	3d	3d	PROPN
biomedich-819	54	3	visualization	visualization	NOUN
biomedich-819	54	4	of	of	ADP
biomedich-819	54	5	the	the	DET
biomedich-819	54	6	best	good	ADJ
biomedich-819	54	7	sirna	sirna	PROPN
biomedich-819	54	8	structure	structure	NOUN
biomedich-819	54	9	provides	provide	VERB
biomedich-819	54	10	a	a	DET
biomedich-819	54	11	detailed	detailed	ADJ
biomedich-819	54	12	overview	overview	NOUN
biomedich-819	54	13	of	of	ADP
biomedich-819	54	14	the	the	DET
biomedich-819	54	15	domain	domain	NOUN
biomedich-819	54	16	arrangement	arrangement	NOUN
biomedich-819	54	17	and	and	CCONJ
biomedich-819	54	18	the	the	DET
biomedich-819	54	19	interactions	interaction	NOUN
biomedich-819	54	20	between	between	ADP
biomedich-819	54	21	the	the	DET
biomedich-819	54	22	sirna	sirna	PROPN
biomedich-819	54	23	binding	binding	NOUN
biomedich-819	54	24	and	and	CCONJ
biomedich-819	54	25	the	the	DET
biomedich-819	54	26	target	target	NOUN
biomedich-819	54	27	rna	rna	PROPN
biomedich-819	54	28	,	,	PUNCT
biomedich-819	54	29	which	which	PRON
biomedich-819	54	30	in	in	ADP
biomedich-819	54	31	this	this	DET
biomedich-819	54	32	case	case	NOUN
biomedich-819	54	33	is	be	AUX
biomedich-819	54	34	icad	icad	ADJ
biomedich-819	54	35	from	from	ADP
biomedich-819	54	36	the	the	DET
biomedich-819	54	37	s.	s.	PROPN
biomedich-819	54	38	aureus	aureus	PROPN
biomedich-819	54	39	biofilm	biofilm	NOUN
biomedich-819	54	40	,	,	PUNCT
biomedich-819	54	41	as	as	SCONJ
biomedich-819	54	42	shown	show	VERB
biomedich-819	54	43	in	in	ADP
biomedich-819	54	44	figure	figure	NOUN
biomedich-819	54	45	1	1	NUM
biomedich-819	54	46	below	below	ADV
biomedich-819	54	47	.	.	PUNCT
biomedich-819	55	1	figure	figure	NOUN
biomedich-819	55	2	1	1	NUM
biomedich-819	55	3	.	.	PUNCT
biomedich-819	56	1	(	(	PUNCT
biomedich-819	56	2	a	a	X
biomedich-819	56	3	)	)	PUNCT
biomedich-819	56	4	the	the	DET
biomedich-819	56	5	structure	structure	NOUN
biomedich-819	56	6	of	of	ADP
biomedich-819	56	7	sirna22	sirna22	NOUN
biomedich-819	56	8	(	(	PUNCT
biomedich-819	56	9	b	b	X
biomedich-819	56	10	)	)	PUNCT
biomedich-819	56	11	the	the	DET
biomedich-819	56	12	structure	structure	NOUN
biomedich-819	56	13	of	of	ADP
biomedich-819	56	14	sirna50	sirna50	NOUN
biomedich-819	56	15	(	(	PUNCT
biomedich-819	56	16	c	c	X
biomedich-819	56	17	)	)	PUNCT
biomedich-819	56	18	the	the	DET
biomedich-819	56	19	structure	structure	NOUN
biomedich-819	56	20	of	of	ADP
biomedich-819	56	21	sirna25	sirna25	NOUN
biomedich-819	56	22	(	(	PUNCT
biomedich-819	56	23	d	d	X
biomedich-819	56	24	)	)	PUNCT
biomedich-819	56	25	the	the	DET
biomedich-819	56	26	structure	structure	NOUN
biomedich-819	56	27	of	of	ADP
biomedich-819	56	28	sirna22	sirna22	NOUN
biomedich-819	56	29	(	(	PUNCT
biomedich-819	56	30	e	e	NOUN
biomedich-819	56	31	)	)	PUNCT
biomedich-819	56	32	the	the	DET
biomedich-819	56	33	structure	structure	NOUN
biomedich-819	56	34	of	of	ADP
biomedich-819	56	35	sirna50	sirna50	NOUN
biomedich-819	56	36	(	(	PUNCT
biomedich-819	56	37	f	f	X
biomedich-819	56	38	)	)	PUNCT
biomedich-819	56	39	the	the	DET
biomedich-819	56	40	structure	structure	NOUN
biomedich-819	56	41	of	of	ADP
biomedich-819	56	42	sirna25	sirna25	NOUN
biomedich-819	56	43	.	.	PUNCT
biomedich-819	57	1	sirna	sirna	PROPN
biomedich-819	57	2	candidates	candidate	NOUN
biomedich-819	57	3	22	22	NUM
biomedich-819	57	4	,	,	PUNCT
biomedich-819	57	5	50	50	NUM
biomedich-819	57	6	,	,	PUNCT
biomedich-819	57	7	and	and	CCONJ
biomedich-819	57	8	25	25	NUM
biomedich-819	57	9	are	be	AUX
biomedich-819	57	10	some	some	PRON
biomedich-819	57	11	of	of	ADP
biomedich-819	57	12	the	the	DET
biomedich-819	57	13	best	good	ADJ
biomedich-819	57	14	targets	target	NOUN
biomedich-819	57	15	for	for	ADP
biomedich-819	57	16	gene	gene	NOUN
biomedich-819	57	17	silencing	silence	VERB
biomedich-819	57	18	based	base	VERB
biomedich-819	57	19	on	on	ADP
biomedich-819	57	20	binding	bind	VERB
biomedich-819	57	21	strength	strength	NOUN
biomedich-819	57	22	and	and	CCONJ
biomedich-819	57	23	the	the	DET
biomedich-819	57	24	highest	high	ADJ
biomedich-819	57	25	predicted	predict	VERB
biomedich-819	57	26	efficacy	efficacy	NOUN
biomedich-819	57	27	among	among	ADP
biomedich-819	57	28	all	all	DET
biomedich-819	57	29	sirna	sirna	PROPN
biomedich-819	57	30	candidates	candidate	NOUN
biomedich-819	57	31	,	,	PUNCT
biomedich-819	57	32	with	with	ADP
biomedich-819	57	33	potential	potential	NOUN
biomedich-819	57	34	to	to	PART
biomedich-819	57	35	exert	exert	VERB
biomedich-819	57	36	a	a	DET
biomedich-819	57	37	suppressive	suppressive	ADJ
biomedich-819	57	38	effect	effect	NOUN
biomedich-819	57	39	on	on	ADP
biomedich-819	57	40	the	the	DET
biomedich-819	57	41	icad	icad	PROPN
biomedich-819	57	42	rna	rna	PROPN
biomedich-819	57	43	.	.	PUNCT
biomedich-819	58	1	discussion	discussion	NOUN
biomedich-819	58	2	the	the	DET
biomedich-819	58	3	sirna	sirna	PROPN
biomedich-819	58	4	molecules	molecule	NOUN
biomedich-819	58	5	were	be	AUX
biomedich-819	58	6	designed	design	VERB
biomedich-819	58	7	using	use	VERB
biomedich-819	58	8	sidirect	sidirect	NOUN
biomedich-819	58	9	with	with	ADP
biomedich-819	58	10	a	a	DET
biomedich-819	58	11	multi	multi	ADJ
biomedich-819	58	12	-	-	ADJ
biomedich-819	58	13	step	step	ADJ
biomedich-819	58	14	bioinformatics	bioinformatic	NOUN
biomedich-819	58	15	screening	screen	VERB
biomedich-819	58	16	approach	approach	NOUN
biomedich-819	58	17	.	.	PUNCT
biomedich-819	59	1	sidirect	sidirect	NOUN
biomedich-819	59	2	provides	provide	VERB
biomedich-819	59	3	functional	functional	ADJ
biomedich-819	59	4	sirna	sirna	PROPN
biomedich-819	59	5	designs	design	NOUN
biomedich-819	59	6	by	by	ADP
biomedich-819	59	7	considering	consider	VERB
biomedich-819	59	8	the	the	DET
biomedich-819	59	9	relationship	relationship	NOUN
biomedich-819	59	10	between	between	ADP
biomedich-819	59	11	sirna	sirna	PROPN
biomedich-819	59	12	sequences	sequence	NOUN
biomedich-819	59	13	and	and	CCONJ
biomedich-819	59	14	rnai	rnai	PROPN
biomedich-819	59	15	activity	activity	NOUN
biomedich-819	59	16	,	,	PUNCT
biomedich-819	59	17	and	and	CCONJ
biomedich-819	59	18	it	it	PRON
biomedich-819	59	19	also	also	ADV
biomedich-819	59	20	calculates	calculate	VERB
biomedich-819	59	21	potential	potential	ADJ
biomedich-819	59	22	gene	gene	NOUN
biomedich-819	59	23	candidates	candidate	NOUN
biomedich-819	59	24	that	that	PRON
biomedich-819	59	25	do	do	AUX
biomedich-819	59	26	not	not	PART
biomedich-819	59	27	match	match	VERB
biomedich-819	59	28	the	the	DET
biomedich-819	59	29	target	target	NOUN
biomedich-819	59	30	.	.	PUNCT
biomedich-819	60	1	the	the	DET
biomedich-819	60	2	rapid	rapid	ADJ
biomedich-819	60	3	and	and	CCONJ
biomedich-819	60	4	sensitive	sensitive	ADJ
biomedich-819	60	5	homology	homology	NOUN
biomedich-819	60	6	search	search	NOUN
biomedich-819	60	7	,	,	PUNCT
biomedich-819	60	8	with	with	ADP
biomedich-819	60	9	an	an	DET
biomedich-819	60	10	updated	update	VERB
biomedich-819	60	11	algorithm	algorithm	NOUN
biomedich-819	60	12	,	,	PUNCT
biomedich-819	60	13	significantly	significantly	ADV
biomedich-819	60	14	reduces	reduce	VERB
biomedich-819	60	15	off	off	ADP
biomedich-819	60	16	-	-	PUNCT
biomedich-819	60	17	target	target	NOUN
biomedich-819	60	18	silencing	silencing	NOUN
biomedich-819	60	19	.	.	PUNCT
biomedich-819	61	1	the	the	DET
biomedich-819	61	2	analysis	analysis	NOUN
biomedich-819	61	3	results	result	NOUN
biomedich-819	61	4	were	be	AUX
biomedich-819	61	5	implemented	implement	VERB
biomedich-819	61	6	to	to	PART
biomedich-819	61	7	select	select	VERB
biomedich-819	61	8	potential	potential	ADJ
biomedich-819	61	9	icad	icad	PROPN
biomedich-819	61	10	gene	gene	NOUN
biomedich-819	61	11	sirna	sirna	PROPN
biomedich-819	61	12	candidates	candidate	NOUN
biomedich-819	61	13	targeting	target	VERB
biomedich-819	61	14	the	the	DET
biomedich-819	61	15	icad	icad	PROPN
biomedich-819	61	16	rna	rna	PROPN
biomedich-819	61	17	of	of	ADP
biomedich-819	61	18	s.	s.	PROPN
biomedich-819	61	19	aureus	aureus	PROPN
biomedich-819	61	20	.	.	PUNCT
biomedich-819	62	1	based	base	VERB
biomedich-819	62	2	on	on	ADP
biomedich-819	62	3	the	the	DET
biomedich-819	62	4	exploration	exploration	NOUN
biomedich-819	62	5	of	of	ADP
biomedich-819	62	6	sirna	sirna	PROPN
biomedich-819	62	7	design	design	PROPN
biomedich-819	62	8	for	for	ADP
biomedich-819	62	9	icad	icad	NOUN
biomedich-819	62	10	using	use	VERB
biomedich-819	62	11	924	924	NUM
biomedich-819	62	12	biology	biology	NOUN
biomedich-819	62	13	,	,	PUNCT
biomedich-819	62	14	medicine	medicine	NOUN
biomedich-819	62	15	,	,	PUNCT
biomedich-819	62	16	&	&	CCONJ
biomedich-819	62	17	natural	natural	ADJ
biomedich-819	62	18	product	product	NOUN
biomedich-819	62	19	chemistry	chemistry	NOUN
biomedich-819	62	20	14	14	NUM
biomedich-819	62	21	(	(	PUNCT
biomedich-819	62	22	2	2	NUM
biomedich-819	62	23	)	)	PUNCT
biomedich-819	62	24	,	,	PUNCT
biomedich-819	62	25	2025	2025	NUM
biomedich-819	62	26	:	:	PUNCT
biomedich-819	62	27	921	921	NUM
biomedich-819	62	28	-	-	SYM
biomedich-819	62	29	926	926	NUM
biomedich-819	62	30	sidirect	sidirect	NOUN
biomedich-819	62	31	,	,	PUNCT
biomedich-819	62	32	54	54	NUM
biomedich-819	62	33	rna	rna	NOUN
biomedich-819	62	34	oligo	oligo	ADJ
biomedich-819	62	35	sequences	sequence	NOUN
biomedich-819	62	36	were	be	AUX
biomedich-819	62	37	obtained	obtain	VERB
biomedich-819	62	38	,	,	PUNCT
biomedich-819	62	39	including	include	VERB
biomedich-819	62	40	21nt	21nt	ADJ
biomedich-819	62	41	guide	guide	NOUN
biomedich-819	62	42	(	(	PUNCT
biomedich-819	62	43	5′→3′	5′→3′	NOUN
biomedich-819	62	44	)	)	PUNCT
biomedich-819	62	45	and	and	CCONJ
biomedich-819	62	46	21nt	21nt	ADJ
biomedich-819	62	47	passenger	passenger	NOUN
biomedich-819	62	48	(	(	PUNCT
biomedich-819	62	49	5′→3′	5′→3′	NOUN
biomedich-819	62	50	)	)	PUNCT
biomedich-819	62	51	rna	rna	NOUN
biomedich-819	62	52	oligo	oligo	ADJ
biomedich-819	62	53	sequences	sequence	NOUN
biomedich-819	62	54	.	.	PUNCT
biomedich-819	63	1	the	the	DET
biomedich-819	63	2	sirna	sirna	PROPN
biomedich-819	63	3	candidates	candidate	NOUN
biomedich-819	63	4	were	be	AUX
biomedich-819	63	5	evaluated	evaluate	VERB
biomedich-819	63	6	using	use	VERB
biomedich-819	63	7	sirna	sirna	PROPN
biomedich-819	63	8	scales	scale	NOUN
biomedich-819	63	9	to	to	PART
biomedich-819	63	10	show	show	VERB
biomedich-819	63	11	the	the	DET
biomedich-819	63	12	analysis	analysis	NOUN
biomedich-819	63	13	results	result	NOUN
biomedich-819	63	14	in	in	ADP
biomedich-819	63	15	the	the	DET
biomedich-819	63	16	form	form	NOUN
biomedich-819	63	17	of	of	ADP
biomedich-819	63	18	the	the	DET
biomedich-819	63	19	percentage	percentage	NOUN
biomedich-819	63	20	of	of	ADP
biomedich-819	63	21	mrna	mrna	NOUN
biomedich-819	63	22	remaining	remain	VERB
biomedich-819	63	23	in	in	ADP
biomedich-819	63	24	the	the	DET
biomedich-819	63	25	cells	cell	NOUN
biomedich-819	63	26	after	after	ADP
biomedich-819	63	27	sirna	sirna	PROPN
biomedich-819	63	28	-	-	PUNCT
biomedich-819	63	29	mediated	mediate	VERB
biomedich-819	63	30	cleavage	cleavage	NOUN
biomedich-819	63	31	.	.	PUNCT
biomedich-819	64	1	the	the	DET
biomedich-819	64	2	range	range	NOUN
biomedich-819	64	3	of	of	ADP
biomedich-819	64	4	predicted	predict	VERB
biomedich-819	64	5	efficiency	efficiency	NOUN
biomedich-819	64	6	values	value	NOUN
biomedich-819	64	7	represents	represent	VERB
biomedich-819	64	8	the	the	DET
biomedich-819	64	9	percentage	percentage	NOUN
biomedich-819	64	10	of	of	ADP
biomedich-819	64	11	mrna	mrna	NOUN
biomedich-819	64	12	remaining	remain	VERB
biomedich-819	64	13	after	after	ADP
biomedich-819	64	14	cleavage	cleavage	NOUN
biomedich-819	64	15	by	by	ADP
biomedich-819	64	16	sirna	sirna	PROPN
biomedich-819	64	17	,	,	PUNCT
biomedich-819	64	18	which	which	PRON
biomedich-819	64	19	refers	refer	VERB
biomedich-819	64	20	to	to	ADP
biomedich-819	64	21	the	the	DET
biomedich-819	64	22	gene	gene	NOUN
biomedich-819	64	23	knockdown	knockdown	NOUN
biomedich-819	64	24	efficiency	efficiency	NOUN
biomedich-819	64	25	by	by	ADP
biomedich-819	64	26	sirna	sirna	PROPN
biomedich-819	64	27	.	.	PUNCT
biomedich-819	65	1	this	this	DET
biomedich-819	65	2	value	value	NOUN
biomedich-819	65	3	is	be	AUX
biomedich-819	65	4	usually	usually	ADV
biomedich-819	65	5	expressed	express	VERB
biomedich-819	65	6	as	as	ADP
biomedich-819	65	7	the	the	DET
biomedich-819	65	8	percentage	percentage	NOUN
biomedich-819	65	9	of	of	ADP
biomedich-819	65	10	mrna	mrna	PROPN
biomedich-819	65	11	that	that	PRON
biomedich-819	65	12	was	be	AUX
biomedich-819	65	13	not	not	PART
biomedich-819	65	14	successfully	successfully	ADV
biomedich-819	65	15	degraded	degrade	VERB
biomedich-819	65	16	(	(	PUNCT
biomedich-819	65	17	remaining	remain	VERB
biomedich-819	65	18	in	in	ADP
biomedich-819	65	19	the	the	DET
biomedich-819	65	20	cell	cell	NOUN
biomedich-819	65	21	)	)	PUNCT
biomedich-819	65	22	.	.	PUNCT
biomedich-819	66	1	sirnas	sirna	NOUN
biomedich-819	66	2	with	with	ADP
biomedich-819	66	3	less	less	ADJ
biomedich-819	66	4	than	than	ADP
biomedich-819	66	5	30	30	NUM
biomedich-819	66	6	%	%	NOUN
biomedich-819	66	7	remaining	remain	VERB
biomedich-819	66	8	mrna	mrna	NOUN
biomedich-819	66	9	are	be	AUX
biomedich-819	66	10	considered	consider	VERB
biomedich-819	66	11	efficient	efficient	ADJ
biomedich-819	66	12	in	in	ADP
biomedich-819	66	13	suppressing	suppress	VERB
biomedich-819	66	14	the	the	DET
biomedich-819	66	15	target	target	NOUN
biomedich-819	66	16	gene	gene	NOUN
biomedich-819	66	17	expression	expression	NOUN
biomedich-819	66	18	.	.	PUNCT
biomedich-819	67	1	in	in	ADP
biomedich-819	67	2	this	this	DET
biomedich-819	67	3	study	study	NOUN
biomedich-819	67	4	,	,	PUNCT
biomedich-819	67	5	sirnas	sirna	NOUN
biomedich-819	67	6	with	with	ADP
biomedich-819	67	7	≤10	≤10	NOUN
biomedich-819	67	8	%	%	NOUN
biomedich-819	67	9	remaining	remain	VERB
biomedich-819	67	10	mrna	mrna	NOUN
biomedich-819	67	11	were	be	AUX
biomedich-819	67	12	categorized	categorize	VERB
biomedich-819	67	13	as	as	ADP
biomedich-819	67	14	highly	highly	ADV
biomedich-819	67	15	effective	effective	ADJ
biomedich-819	67	16	because	because	SCONJ
biomedich-819	67	17	they	they	PRON
biomedich-819	67	18	resulted	result	VERB
biomedich-819	67	19	in	in	ADP
biomedich-819	67	20	nearly	nearly	ADV
biomedich-819	67	21	perfect	perfect	ADJ
biomedich-819	67	22	knockdown	knockdown	NOUN
biomedich-819	67	23	.	.	PUNCT
biomedich-819	68	1	meanwhile	meanwhile	ADV
biomedich-819	68	2	,	,	PUNCT
biomedich-819	68	3	sirnas	sirna	NOUN
biomedich-819	68	4	with	with	ADP
biomedich-819	68	5	10–30	10–30	NUM
biomedich-819	68	6	%	%	NOUN
biomedich-819	68	7	remaining	remain	VERB
biomedich-819	68	8	mrna	mrna	NOUN
biomedich-819	68	9	are	be	AUX
biomedich-819	68	10	still	still	ADV
biomedich-819	68	11	quite	quite	ADV
biomedich-819	68	12	effective	effective	ADJ
biomedich-819	68	13	for	for	ADP
biomedich-819	68	14	certain	certain	ADJ
biomedich-819	68	15	biological	biological	ADJ
biomedich-819	68	16	applications	application	NOUN
biomedich-819	68	17	.	.	PUNCT
biomedich-819	69	1	on	on	ADP
biomedich-819	69	2	the	the	DET
biomedich-819	69	3	other	other	ADJ
biomedich-819	69	4	hand	hand	NOUN
biomedich-819	69	5	,	,	PUNCT
biomedich-819	69	6	sirnas	sirna	NOUN
biomedich-819	69	7	with	with	ADP
biomedich-819	69	8	>	>	SYM
biomedich-819	69	9	30	30	NUM
biomedich-819	69	10	%	%	NOUN
biomedich-819	69	11	remaining	remain	VERB
biomedich-819	69	12	mrna	mrna	NOUN
biomedich-819	69	13	are	be	AUX
biomedich-819	69	14	considered	consider	VERB
biomedich-819	69	15	to	to	PART
biomedich-819	69	16	have	have	VERB
biomedich-819	69	17	low	low	ADJ
biomedich-819	69	18	knockdown	knockdown	NOUN
biomedich-819	69	19	efficiency	efficiency	NOUN
biomedich-819	69	20	and	and	CCONJ
biomedich-819	69	21	are	be	AUX
biomedich-819	69	22	typically	typically	ADV
biomedich-819	69	23	avoided	avoid	VERB
biomedich-819	69	24	as	as	ADP
biomedich-819	69	25	candidates	candidate	NOUN
biomedich-819	69	26	.	.	PUNCT
biomedich-819	70	1	the	the	PRON
biomedich-819	70	2	smaller	small	ADJ
biomedich-819	70	3	the	the	DET
biomedich-819	70	4	percentage	percentage	NOUN
biomedich-819	70	5	of	of	ADP
biomedich-819	70	6	remaining	remain	VERB
biomedich-819	70	7	mrna	mrna	PROPN
biomedich-819	70	8	,	,	PUNCT
biomedich-819	70	9	the	the	PRON
biomedich-819	70	10	higher	high	ADJ
biomedich-819	70	11	the	the	DET
biomedich-819	70	12	effectiveness	effectiveness	NOUN
biomedich-819	70	13	of	of	ADP
biomedich-819	70	14	the	the	DET
biomedich-819	70	15	sirna	sirna	PROPN
biomedich-819	70	16	in	in	ADP
biomedich-819	70	17	working	work	VERB
biomedich-819	70	18	according	accord	VERB
biomedich-819	70	19	to	to	ADP
biomedich-819	70	20	its	its	PRON
biomedich-819	70	21	target	target	NOUN
biomedich-819	70	22	without	without	ADP
biomedich-819	70	23	indirectly	indirectly	ADV
biomedich-819	70	24	affecting	affect	VERB
biomedich-819	70	25	other	other	ADJ
biomedich-819	70	26	genes	gene	NOUN
biomedich-819	70	27	or	or	CCONJ
biomedich-819	70	28	processes	process	NOUN
biomedich-819	70	29	(	(	PUNCT
biomedich-819	70	30	angart	angart	NOUN
biomedich-819	70	31	et	et	PROPN
biomedich-819	70	32	al	al	PROPN
biomedich-819	70	33	.	.	PROPN
biomedich-819	70	34	,	,	PUNCT
biomedich-819	70	35	2013	2013	NUM
biomedich-819	70	36	;	;	PUNCT
biomedich-819	70	37	dana	dana	PROPN
biomedich-819	70	38	et	et	PROPN
biomedich-819	70	39	al	al	PROPN
biomedich-819	70	40	.	.	PROPN
biomedich-819	70	41	,	,	PUNCT
biomedich-819	70	42	2017	2017	NUM
biomedich-819	70	43	)	)	PUNCT
biomedich-819	70	44	.	.	PUNCT
biomedich-819	71	1	based	base	VERB
biomedich-819	71	2	on	on	ADP
biomedich-819	71	3	guidelines	guideline	NOUN
biomedich-819	71	4	from	from	ADP
biomedich-819	71	5	sirna	sirna	PROPN
biomedich-819	71	6	design	design	PROPN
biomedich-819	71	7	,	,	PUNCT
biomedich-819	71	8	such	such	ADJ
biomedich-819	71	9	as	as	ADP
biomedich-819	71	10	those	those	PRON
biomedich-819	71	11	from	from	ADP
biomedich-819	71	12	biotechnology	biotechnology	NOUN
biomedich-819	71	13	companies	company	NOUN
biomedich-819	71	14	(	(	PUNCT
biomedich-819	71	15	thermo	thermo	NOUN
biomedich-819	71	16	fisher	fisher	PROPN
biomedich-819	71	17	scientific	scientific	PROPN
biomedich-819	71	18	,	,	PUNCT
biomedich-819	71	19	qiagen	qiagen	NOUN
biomedich-819	71	20	,	,	PUNCT
biomedich-819	71	21	or	or	CCONJ
biomedich-819	71	22	dharmacon	dharmacon	NOUN
biomedich-819	71	23	)	)	PUNCT
biomedich-819	71	24	,	,	PUNCT
biomedich-819	71	25	high	high	ADJ
biomedich-819	71	26	doses	dose	NOUN
biomedich-819	71	27	(	(	PUNCT
biomedich-819	71	28	>	>	SYM
biomedich-819	71	29	30	30	NUM
biomedich-819	71	30	%	%	NOUN
biomedich-819	71	31	)	)	PUNCT
biomedich-819	71	32	may	may	AUX
biomedich-819	71	33	increase	increase	VERB
biomedich-819	71	34	the	the	DET
biomedich-819	71	35	risk	risk	NOUN
biomedich-819	71	36	of	of	ADP
biomedich-819	71	37	nonspecific	nonspecific	ADJ
biomedich-819	71	38	effects	effect	NOUN
biomedich-819	71	39	,	,	PUNCT
biomedich-819	71	40	such	such	ADJ
biomedich-819	71	41	as	as	ADP
biomedich-819	71	42	activation	activation	NOUN
biomedich-819	71	43	of	of	ADP
biomedich-819	71	44	the	the	DET
biomedich-819	71	45	interferon	interferon	ADJ
biomedich-819	71	46	pathway	pathway	NOUN
biomedich-819	71	47	or	or	CCONJ
biomedich-819	71	48	off	off	ADP
biomedich-819	71	49	-	-	PUNCT
biomedich-819	71	50	target	target	NOUN
biomedich-819	71	51	effects	effect	NOUN
biomedich-819	71	52	.	.	PUNCT
biomedich-819	72	1	a	a	DET
biomedich-819	72	2	low	low	ADJ
biomedich-819	72	3	percentage	percentage	NOUN
biomedich-819	72	4	of	of	ADP
biomedich-819	72	5	remaining	remaining	ADJ
biomedich-819	72	6	mrna	mrna	PROPN
biomedich-819	72	7	indicates	indicate	VERB
biomedich-819	72	8	a	a	DET
biomedich-819	72	9	more	more	ADV
biomedich-819	72	10	effective	effective	ADJ
biomedich-819	72	11	mrna	mrna	NOUN
biomedich-819	72	12	cleavage	cleavage	NOUN
biomedich-819	72	13	by	by	ADP
biomedich-819	72	14	the	the	DET
biomedich-819	72	15	risc	risc	PROPN
biomedich-819	72	16	complex	complex	NOUN
biomedich-819	72	17	,	,	PUNCT
biomedich-819	72	18	thereby	thereby	ADV
biomedich-819	72	19	enhancing	enhance	VERB
biomedich-819	72	20	the	the	DET
biomedich-819	72	21	knockdown	knockdown	NOUN
biomedich-819	72	22	efficiency	efficiency	NOUN
biomedich-819	72	23	of	of	ADP
biomedich-819	72	24	the	the	DET
biomedich-819	72	25	target	target	NOUN
biomedich-819	72	26	gene	gene	NOUN
biomedich-819	72	27	(	(	PUNCT
biomedich-819	72	28	bartel	bartel	NOUN
biomedich-819	72	29	&	&	CCONJ
biomedich-819	72	30	sharp	sharp	PROPN
biomedich-819	72	31	.	.	PROPN
biomedich-819	72	32	,	,	PUNCT
biomedich-819	72	33	2004	2004	NUM
biomedich-819	72	34	)	)	PUNCT
biomedich-819	72	35	.	.	PUNCT
biomedich-819	73	1	the	the	DET
biomedich-819	73	2	candidate	candidate	NOUN
biomedich-819	73	3	sirna	sirna	PROPN
biomedich-819	73	4	was	be	AUX
biomedich-819	73	5	further	far	ADV
biomedich-819	73	6	analyzed	analyze	VERB
biomedich-819	73	7	using	use	VERB
biomedich-819	73	8	maxexpect	maxexpect	NOUN
biomedich-819	73	9	and	and	CCONJ
biomedich-819	73	10	duplexfold	duplexfold	ADJ
biomedich-819	73	11	to	to	PART
biomedich-819	73	12	calculate	calculate	VERB
biomedich-819	73	13	the	the	DET
biomedich-819	73	14	free	free	ADJ
biomedich-819	73	15	binding	bind	VERB
biomedich-819	73	16	energy	energy	NOUN
biomedich-819	73	17	of	of	ADP
biomedich-819	73	18	the	the	DET
biomedich-819	73	19	sirna	sirna	PROPN
biomedich-819	73	20	and	and	CCONJ
biomedich-819	73	21	the	the	DET
biomedich-819	73	22	free	free	ADJ
biomedich-819	73	23	binding	bind	VERB
biomedich-819	73	24	energy	energy	NOUN
biomedich-819	73	25	between	between	ADP
biomedich-819	73	26	the	the	DET
biomedich-819	73	27	guide	guide	NOUN
biomedich-819	73	28	strand	strand	NOUN
biomedich-819	73	29	and	and	CCONJ
biomedich-819	73	30	the	the	DET
biomedich-819	73	31	target	target	NOUN
biomedich-819	73	32	.	.	PUNCT
biomedich-819	74	1	maxexpect	maxexpect	PROPN
biomedich-819	74	2	was	be	AUX
biomedich-819	74	3	tested	test	VERB
biomedich-819	74	4	on	on	ADP
biomedich-819	74	5	a	a	DET
biomedich-819	74	6	database	database	NOUN
biomedich-819	74	7	of	of	ADP
biomedich-819	74	8	sirna	sirna	PROPN
biomedich-819	74	9	sequences	sequence	NOUN
biomedich-819	74	10	for	for	ADP
biomedich-819	74	11	the	the	DET
biomedich-819	74	12	icad	icad	ADJ
biomedich-819	74	13	antigen	antigen	NOUN
biomedich-819	74	14	of	of	ADP
biomedich-819	74	15	s.	s.	PROPN
biomedich-819	74	16	aureus	aureus	PROPN
biomedich-819	74	17	with	with	ADP
biomedich-819	74	18	known	know	VERB
biomedich-819	74	19	secondary	secondary	ADJ
biomedich-819	74	20	structures	structure	NOUN
biomedich-819	74	21	.	.	PUNCT
biomedich-819	75	1	maxexpect	maxexpect	VERB
biomedich-819	75	2	predicts	predict	VERB
biomedich-819	75	3	the	the	DET
biomedich-819	75	4	optimal	optimal	ADJ
biomedich-819	75	5	structure	structure	NOUN
biomedich-819	75	6	(	(	PUNCT
biomedich-819	75	7	with	with	ADP
biomedich-819	75	8	the	the	DET
biomedich-819	75	9	highest	high	ADJ
biomedich-819	75	10	expected	expect	VERB
biomedich-819	75	11	strand	strand	NOUN
biomedich-819	75	12	accuracy	accuracy	NOUN
biomedich-819	75	13	)	)	PUNCT
biomedich-819	75	14	and	and	CCONJ
biomedich-819	75	15	suboptimal	suboptimal	ADJ
biomedich-819	75	16	structures	structure	NOUN
biomedich-819	75	17	as	as	ADP
biomedich-819	75	18	alternative	alternative	ADJ
biomedich-819	75	19	hypotheses	hypothesis	NOUN
biomedich-819	75	20	for	for	ADP
biomedich-819	75	21	that	that	DET
biomedich-819	75	22	structure	structure	NOUN
biomedich-819	75	23	.	.	PUNCT
biomedich-819	76	1	the	the	DET
biomedich-819	76	2	optimal	optimal	ADJ
biomedich-819	76	3	structure	structure	NOUN
biomedich-819	76	4	,	,	PUNCT
biomedich-819	76	5	the	the	DET
biomedich-819	76	6	maximum	maximum	ADJ
biomedich-819	76	7	expected	expect	VERB
biomedich-819	76	8	accuracy	accuracy	NOUN
biomedich-819	76	9	structure	structure	NOUN
biomedich-819	76	10	,	,	PUNCT
biomedich-819	76	11	is	be	AUX
biomedich-819	76	12	predicted	predict	VERB
biomedich-819	76	13	and	and	CCONJ
biomedich-819	76	14	compared	compare	VERB
biomedich-819	76	15	with	with	ADP
biomedich-819	76	16	the	the	DET
biomedich-819	76	17	known	know	VERB
biomedich-819	76	18	structure	structure	NOUN
biomedich-819	76	19	in	in	ADP
biomedich-819	76	20	the	the	DET
biomedich-819	76	21	database	database	NOUN
biomedich-819	76	22	,	,	PUNCT
biomedich-819	76	23	and	and	CCONJ
biomedich-819	76	24	the	the	DET
biomedich-819	76	25	prediction	prediction	NOUN
biomedich-819	76	26	accuracy	accuracy	NOUN
biomedich-819	76	27	is	be	AUX
biomedich-819	76	28	reported	report	VERB
biomedich-819	76	29	as	as	ADP
biomedich-819	76	30	sensitivity	sensitivity	NOUN
biomedich-819	76	31	and	and	CCONJ
biomedich-819	76	32	ppv	ppv	NOUN
biomedich-819	76	33	(	(	PUNCT
biomedich-819	76	34	positive	positive	ADJ
biomedich-819	76	35	predictive	predictive	ADJ
biomedich-819	76	36	value	value	NOUN
biomedich-819	76	37	)	)	PUNCT
biomedich-819	77	1	(	(	PUNCT
biomedich-819	77	2	lu	lu	NOUN
biomedich-819	77	3	et	et	PROPN
biomedich-819	77	4	al	al	PROPN
biomedich-819	77	5	.	.	PROPN
biomedich-819	77	6	,	,	PUNCT
biomedich-819	77	7	2009	2009	NUM
biomedich-819	77	8	)	)	PUNCT
biomedich-819	77	9	.	.	PUNCT
biomedich-819	78	1	target	target	NOUN
biomedich-819	78	2	mrna	mrna	NOUN
biomedich-819	78	3	regions	region	NOUN
biomedich-819	78	4	with	with	ADP
biomedich-819	78	5	maxexpect	maxexpect	ADJ
biomedich-819	78	6	values	value	NOUN
biomedich-819	78	7	>	>	PUNCT
biomedich-819	78	8	1.5	1.5	NUM
biomedich-819	78	9	indicate	indicate	VERB
biomedich-819	78	10	high	high	ADJ
biomedich-819	78	11	accessibility	accessibility	NOUN
biomedich-819	78	12	to	to	ADP
biomedich-819	78	13	sirna	sirna	PROPN
biomedich-819	78	14	,	,	PUNCT
biomedich-819	78	15	reflecting	reflect	VERB
biomedich-819	78	16	greater	great	ADJ
biomedich-819	78	17	sensitivity	sensitivity	NOUN
biomedich-819	78	18	in	in	ADP
biomedich-819	78	19	identifying	identify	VERB
biomedich-819	78	20	open	open	ADJ
biomedich-819	78	21	target	target	NOUN
biomedich-819	78	22	areas	area	NOUN
biomedich-819	78	23	.	.	PUNCT
biomedich-819	79	1	this	this	PRON
biomedich-819	79	2	increases	increase	VERB
biomedich-819	79	3	the	the	DET
biomedich-819	79	4	chances	chance	NOUN
biomedich-819	79	5	of	of	ADP
biomedich-819	79	6	successful	successful	ADJ
biomedich-819	79	7	sirna	sirna	PROPN
biomedich-819	79	8	knockdown	knockdown	NOUN
biomedich-819	79	9	.	.	PUNCT
biomedich-819	80	1	furthermore	furthermore	ADV
biomedich-819	80	2	,	,	PUNCT
biomedich-819	80	3	higher	high	ADJ
biomedich-819	80	4	predicted	predict	VERB
biomedich-819	80	5	ppv	ppv	NOUN
biomedich-819	80	6	supports	support	VERB
biomedich-819	80	7	the	the	DET
biomedich-819	80	8	effectiveness	effectiveness	NOUN
biomedich-819	80	9	of	of	ADP
biomedich-819	80	10	sirna	sirna	PROPN
biomedich-819	80	11	in	in	ADP
biomedich-819	80	12	reducing	reduce	VERB
biomedich-819	80	13	target	target	NOUN
biomedich-819	80	14	gene	gene	NOUN
biomedich-819	80	15	expression	expression	NOUN
biomedich-819	80	16	during	during	ADP
biomedich-819	80	17	experimental	experimental	ADJ
biomedich-819	80	18	tests	test	NOUN
biomedich-819	80	19	.	.	PUNCT
biomedich-819	81	1	therefore	therefore	ADV
biomedich-819	81	2	,	,	PUNCT
biomedich-819	81	3	maxexpect	maxexpect	VERB
biomedich-819	81	4	values	value	NOUN
biomedich-819	81	5	>	>	SYM
biomedich-819	81	6	1.5	1.5	NUM
biomedich-819	81	7	can	can	AUX
biomedich-819	81	8	be	be	AUX
biomedich-819	81	9	considered	consider	VERB
biomedich-819	81	10	optimal	optimal	ADJ
biomedich-819	81	11	,	,	PUNCT
biomedich-819	81	12	especially	especially	ADV
biomedich-819	81	13	when	when	SCONJ
biomedich-819	81	14	supported	support	VERB
biomedich-819	81	15	by	by	ADP
biomedich-819	81	16	other	other	ADJ
biomedich-819	81	17	parameters	parameter	NOUN
biomedich-819	81	18	such	such	ADJ
biomedich-819	81	19	as	as	ADP
biomedich-819	81	20	knockdown	knockdown	NOUN
biomedich-819	81	21	prediction	prediction	NOUN
biomedich-819	81	22	results	result	NOUN
biomedich-819	81	23	showing	show	VERB
biomedich-819	81	24	remaining	remain	VERB
biomedich-819	81	25	mrna	mrna	PROPN
biomedich-819	81	26	≤30	≤30	PROPN
biomedich-819	81	27	%	%	NOUN
biomedich-819	81	28	,	,	PUNCT
biomedich-819	81	29	as	as	SCONJ
biomedich-819	81	30	analyzed	analyze	VERB
biomedich-819	81	31	through	through	ADP
biomedich-819	81	32	previous	previous	ADJ
biomedich-819	81	33	sirna	sirna	PROPN
biomedich-819	81	34	scales	scale	NOUN
biomedich-819	81	35	(	(	PUNCT
biomedich-819	81	36	pan	pan	PROPN
biomedich-819	81	37	et	et	PROPN
biomedich-819	81	38	al	al	PROPN
biomedich-819	81	39	.	.	PROPN
biomedich-819	81	40	,	,	PUNCT
biomedich-819	81	41	2011	2011	NUM
biomedich-819	81	42	;	;	PUNCT
biomedich-819	81	43	mysara	mysara	PROPN
biomedich-819	81	44	&	&	CCONJ
biomedich-819	81	45	garibaldi	garibaldi	PROPN
biomedich-819	81	46	,	,	PUNCT
biomedich-819	81	47	2011	2011	NUM
biomedich-819	81	48	;	;	PUNCT
biomedich-819	81	49	filhol	filhol	NOUN
biomedich-819	81	50	et	et	PROPN
biomedich-819	81	51	al	al	PROPN
biomedich-819	81	52	.	.	PROPN
biomedich-819	81	53	,	,	PUNCT
biomedich-819	81	54	2012	2012	NUM
biomedich-819	81	55	)	)	PUNCT
biomedich-819	81	56	.	.	PUNCT
biomedich-819	82	1	the	the	DET
biomedich-819	82	2	duplexfold	duplexfold	ADJ
biomedich-819	82	3	analysis	analysis	NOUN
biomedich-819	82	4	is	be	AUX
biomedich-819	82	5	conducted	conduct	VERB
biomedich-819	82	6	to	to	PART
biomedich-819	82	7	find	find	VERB
biomedich-819	82	8	the	the	DET
biomedich-819	82	9	structure	structure	NOUN
biomedich-819	82	10	with	with	ADP
biomedich-819	82	11	the	the	DET
biomedich-819	82	12	gibbs	gibbs	PROPN
biomedich-819	82	13	free	free	ADJ
biomedich-819	82	14	energy	energy	NOUN
biomedich-819	82	15	(	(	PUNCT
biomedich-819	82	16	δg	δg	NOUN
biomedich-819	82	17	)	)	PUNCT
biomedich-819	82	18	,	,	PUNCT
biomedich-819	82	19	which	which	PRON
biomedich-819	82	20	is	be	AUX
biomedich-819	82	21	a	a	DET
biomedich-819	82	22	measure	measure	NOUN
biomedich-819	82	23	used	use	VERB
biomedich-819	82	24	to	to	PART
biomedich-819	82	25	calculate	calculate	VERB
biomedich-819	82	26	the	the	DET
biomedich-819	82	27	maximum	maximum	ADJ
biomedich-819	82	28	work	work	NOUN
biomedich-819	82	29	that	that	PRON
biomedich-819	82	30	can	can	AUX
biomedich-819	82	31	be	be	AUX
biomedich-819	82	32	done	do	VERB
biomedich-819	82	33	in	in	ADP
biomedich-819	82	34	a	a	DET
biomedich-819	82	35	thermodynamic	thermodynamic	ADJ
biomedich-819	82	36	system	system	NOUN
biomedich-819	82	37	when	when	SCONJ
biomedich-819	82	38	temperature	temperature	NOUN
biomedich-819	82	39	and	and	CCONJ
biomedich-819	82	40	pressure	pressure	NOUN
biomedich-819	82	41	are	be	AUX
biomedich-819	82	42	kept	keep	VERB
biomedich-819	82	43	constant	constant	ADJ
biomedich-819	82	44	,	,	PUNCT
biomedich-819	82	45	indicating	indicate	VERB
biomedich-819	82	46	the	the	DET
biomedich-819	82	47	most	most	ADV
biomedich-819	82	48	stable	stable	ADJ
biomedich-819	82	49	conformation	conformation	NOUN
biomedich-819	82	50	under	under	ADP
biomedich-819	82	51	specific	specific	ADJ
biomedich-819	82	52	thermodynamic	thermodynamic	ADJ
biomedich-819	82	53	conditions	condition	NOUN
biomedich-819	82	54	.	.	PUNCT
biomedich-819	83	1	duplexfold	duplexfold	PROPN
biomedich-819	83	2	predicts	predict	VERB
biomedich-819	83	3	the	the	DET
biomedich-819	83	4	lowest	low	ADJ
biomedich-819	83	5	free	free	ADJ
biomedich-819	83	6	energy	energy	NOUN
biomedich-819	83	7	conformation	conformation	NOUN
biomedich-819	83	8	of	of	ADP
biomedich-819	83	9	rna	rna	NOUN
biomedich-819	83	10	hybrid	hybrid	NOUN
biomedich-819	83	11	duplexes	duplex	NOUN
biomedich-819	83	12	based	base	VERB
biomedich-819	83	13	on	on	ADP
biomedich-819	83	14	intermolecular	intermolecular	ADJ
biomedich-819	83	15	base	base	NOUN
biomedich-819	83	16	pairing	pairing	NOUN
biomedich-819	83	17	,	,	PUNCT
biomedich-819	83	18	while	while	SCONJ
biomedich-819	83	19	targetrna	targetrna	NOUN
biomedich-819	83	20	identifies	identify	VERB
biomedich-819	83	21	the	the	DET
biomedich-819	83	22	complementarity	complementarity	NOUN
biomedich-819	83	23	of	of	ADP
biomedich-819	83	24	base	base	NOUN
biomedich-819	83	25	strands	strand	NOUN
biomedich-819	83	26	and	and	CCONJ
biomedich-819	83	27	calculates	calculate	VERB
biomedich-819	83	28	the	the	DET
biomedich-819	83	29	rri	rri	NOUN
biomedich-819	83	30	score	score	NOUN
biomedich-819	83	31	using	use	VERB
biomedich-819	83	32	the	the	DET
biomedich-819	83	33	mean	mean	ADJ
biomedich-819	83	34	forecast	forecast	NOUN
biomedich-819	83	35	error	error	NOUN
biomedich-819	83	36	(	(	PUNCT
biomedich-819	83	37	mfe	mfe	NOUN
biomedich-819	83	38	)	)	PUNCT
biomedich-819	83	39	model	model	NOUN
biomedich-819	83	40	for	for	ADP
biomedich-819	83	41	rna	rna	NOUN
biomedich-819	83	42	duplexes	duplex	NOUN
biomedich-819	83	43	(	(	PUNCT
biomedich-819	83	44	lybarger	lybarger	NOUN
biomedich-819	83	45	&	&	CCONJ
biomedich-819	83	46	sandkvist	sandkvist	PROPN
biomedich-819	83	47	,	,	PUNCT
biomedich-819	83	48	2004	2004	NUM
biomedich-819	83	49	)	)	PUNCT
biomedich-819	83	50	.	.	PUNCT
biomedich-819	84	1	two	two	NUM
biomedich-819	84	2	sirna	sirna	PROPN
biomedich-819	84	3	candidates	candidate	NOUN
biomedich-819	84	4	that	that	PRON
biomedich-819	84	5	did	do	AUX
biomedich-819	84	6	not	not	PART
biomedich-819	84	7	meet	meet	VERB
biomedich-819	84	8	the	the	DET
biomedich-819	84	9	criteria	criterion	NOUN
biomedich-819	84	10	,	,	PUNCT
biomedich-819	84	11	with	with	ADP
biomedich-819	84	12	duplexfold	duplexfold	ADJ
biomedich-819	84	13	results	result	NOUN
biomedich-819	84	14	ranging	range	VERB
biomedich-819	84	15	from	from	ADP
biomedich-819	84	16	36.1	36.1	NUM
biomedich-819	84	17	to	to	ADP
biomedich-819	84	18	-20.5	-20.5	NUM
biomedich-819	84	19	kcal	kcal	NOUN
biomedich-819	84	20	/	/	SYM
biomedich-819	84	21	mol	mol	PROPN
biomedich-819	84	22	,	,	PUNCT
biomedich-819	84	23	which	which	PRON
biomedich-819	84	24	is	be	AUX
biomedich-819	84	25	the	the	DET
biomedich-819	84	26	optimal	optimal	ADJ
biomedich-819	84	27	binding	binding	ADJ
biomedich-819	84	28	free	free	ADJ
biomedich-819	84	29	energy	energy	NOUN
biomedich-819	84	30	value	value	NOUN
biomedich-819	84	31	generated	generate	VERB
biomedich-819	84	32	for	for	ADP
biomedich-819	84	33	sirna	sirna	PROPN
biomedich-819	84	34	prediction	prediction	PROPN
biomedich-819	84	35	,	,	PUNCT
biomedich-819	84	36	were	be	AUX
biomedich-819	84	37	eliminated	eliminate	VERB
biomedich-819	84	38	.	.	PUNCT
biomedich-819	85	1	in	in	ADP
biomedich-819	85	2	the	the	DET
biomedich-819	85	3	context	context	NOUN
biomedich-819	85	4	of	of	ADP
biomedich-819	85	5	selecting	select	VERB
biomedich-819	85	6	the	the	DET
biomedich-819	85	7	most	most	ADV
biomedich-819	85	8	effective	effective	ADJ
biomedich-819	85	9	sirna	sirna	PROPN
biomedich-819	85	10	,	,	PUNCT
biomedich-819	85	11	a	a	PRON
biomedich-819	85	12	lower	low	ADJ
biomedich-819	85	13	(	(	PUNCT
biomedich-819	85	14	more	more	ADV
biomedich-819	85	15	negative	negative	ADJ
biomedich-819	85	16	)	)	PUNCT
biomedich-819	85	17	δg	δg	PRON
biomedich-819	85	18	value	value	NOUN
biomedich-819	85	19	typically	typically	ADV
biomedich-819	85	20	indicates	indicate	VERB
biomedich-819	85	21	a	a	DET
biomedich-819	85	22	stronger	strong	ADJ
biomedich-819	85	23	and	and	CCONJ
biomedich-819	85	24	more	more	ADV
biomedich-819	85	25	stable	stable	ADJ
biomedich-819	85	26	interaction	interaction	NOUN
biomedich-819	85	27	between	between	ADP
biomedich-819	85	28	the	the	DET
biomedich-819	85	29	sirna	sirna	PROPN
biomedich-819	85	30	and	and	CCONJ
biomedich-819	85	31	the	the	DET
biomedich-819	85	32	target	target	NOUN
biomedich-819	85	33	mrna	mrna	PROPN
biomedich-819	85	34	,	,	PUNCT
biomedich-819	85	35	which	which	PRON
biomedich-819	85	36	leads	lead	VERB
biomedich-819	85	37	to	to	ADP
biomedich-819	85	38	more	more	ADV
biomedich-819	85	39	effective	effective	ADJ
biomedich-819	85	40	gene	gene	NOUN
biomedich-819	85	41	silencing	silencing	NOUN
biomedich-819	85	42	.	.	PUNCT
biomedich-819	86	1	this	this	DET
biomedich-819	86	2	more	more	ADV
biomedich-819	86	3	stable	stable	ADJ
biomedich-819	86	4	interaction	interaction	NOUN
biomedich-819	86	5	is	be	AUX
biomedich-819	86	6	crucial	crucial	ADJ
biomedich-819	86	7	because	because	SCONJ
biomedich-819	86	8	it	it	PRON
biomedich-819	86	9	allows	allow	VERB
biomedich-819	86	10	the	the	DET
biomedich-819	86	11	sirna	sirna	PROPN
biomedich-819	86	12	to	to	PART
biomedich-819	86	13	more	more	ADV
biomedich-819	86	14	effectively	effectively	ADV
biomedich-819	86	15	guide	guide	VERB
biomedich-819	86	16	the	the	DET
biomedich-819	86	17	rna	rna	NOUN
biomedich-819	86	18	interference	interference	NOUN
biomedich-819	86	19	(	(	PUNCT
biomedich-819	86	20	rnai	rnai	NOUN
biomedich-819	86	21	)	)	PUNCT
biomedich-819	86	22	process	process	NOUN
biomedich-819	86	23	to	to	PART
biomedich-819	86	24	reduce	reduce	VERB
biomedich-819	86	25	the	the	DET
biomedich-819	86	26	expression	expression	NOUN
biomedich-819	86	27	of	of	ADP
biomedich-819	86	28	the	the	DET
biomedich-819	86	29	target	target	NOUN
biomedich-819	86	30	gene	gene	NOUN
biomedich-819	86	31	.	.	PUNCT
biomedich-819	87	1	the	the	PRON
biomedich-819	87	2	lower	low	ADJ
biomedich-819	87	3	the	the	DET
biomedich-819	87	4	δg	δg	ADJ
biomedich-819	87	5	value	value	NOUN
biomedich-819	87	6	,	,	PUNCT
biomedich-819	87	7	the	the	PRON
biomedich-819	87	8	stronger	strong	ADJ
biomedich-819	87	9	the	the	DET
biomedich-819	87	10	binding	binding	NOUN
biomedich-819	87	11	between	between	ADP
biomedich-819	87	12	the	the	DET
biomedich-819	87	13	sirna	sirna	PROPN
biomedich-819	87	14	and	and	CCONJ
biomedich-819	87	15	mrna	mrna	PROPN
biomedich-819	87	16	,	,	PUNCT
biomedich-819	87	17	which	which	PRON
biomedich-819	87	18	increases	increase	VERB
biomedich-819	87	19	the	the	DET
biomedich-819	87	20	likelihood	likelihood	NOUN
biomedich-819	87	21	of	of	ADP
biomedich-819	87	22	forming	form	VERB
biomedich-819	87	23	a	a	DET
biomedich-819	87	24	functional	functional	ADJ
biomedich-819	87	25	risc	risc	PROPN
biomedich-819	87	26	complex	complex	NOUN
biomedich-819	87	27	,	,	PUNCT
biomedich-819	87	28	an	an	DET
biomedich-819	87	29	essential	essential	ADJ
biomedich-819	87	30	factor	factor	NOUN
biomedich-819	87	31	in	in	ADP
biomedich-819	87	32	the	the	DET
biomedich-819	87	33	effectiveness	effectiveness	NOUN
biomedich-819	87	34	of	of	ADP
biomedich-819	87	35	gene	gene	NOUN
biomedich-819	87	36	silencing	silence	VERB
biomedich-819	87	37	(	(	PUNCT
biomedich-819	87	38	kajino	kajino	PROPN
biomedich-819	87	39	et	et	PROPN
biomedich-819	87	40	al	al	PROPN
biomedich-819	87	41	.	.	PROPN
biomedich-819	87	42	,	,	PUNCT
biomedich-819	87	43	2022	2022	NUM
biomedich-819	87	44	)	)	PUNCT
biomedich-819	87	45	.	.	PUNCT
biomedich-819	88	1	the	the	DET
biomedich-819	88	2	inhibition	inhibition	NOUN
biomedich-819	88	3	ability	ability	NOUN
biomedich-819	88	4	of	of	ADP
biomedich-819	88	5	the	the	DET
biomedich-819	88	6	selected	select	VERB
biomedich-819	88	7	remaining	remain	VERB
biomedich-819	88	8	sirna	sirna	PROPN
biomedich-819	88	9	is	be	AUX
biomedich-819	88	10	predicted	predict	VERB
biomedich-819	88	11	using	using	AUX
biomedich-819	88	12	sipred	sipre	VERB
biomedich-819	88	13	.	.	PUNCT
biomedich-819	89	1	accurate	accurate	ADJ
biomedich-819	89	2	predictions	prediction	NOUN
biomedich-819	89	3	will	will	AUX
biomedich-819	89	4	facilitate	facilitate	VERB
biomedich-819	89	5	the	the	DET
biomedich-819	89	6	design	design	NOUN
biomedich-819	89	7	of	of	ADP
biomedich-819	89	8	optimized	optimize	VERB
biomedich-819	89	9	sirna	sirna	PROPN
biomedich-819	89	10	by	by	ADP
biomedich-819	89	11	maximizing	maximize	VERB
biomedich-819	89	12	the	the	DET
biomedich-819	89	13	success	success	NOUN
biomedich-819	89	14	of	of	ADP
biomedich-819	89	15	the	the	DET
biomedich-819	89	16	knockout	knockout	NOUN
biomedich-819	89	17	of	of	ADP
biomedich-819	89	18	the	the	DET
biomedich-819	89	19	sirna	sirna	PROPN
biomedich-819	89	20	candidate	candidate	NOUN
biomedich-819	89	21	on	on	ADP
biomedich-819	89	22	the	the	DET
biomedich-819	89	23	target	target	NOUN
biomedich-819	89	24	(	(	PUNCT
biomedich-819	89	25	high	high	ADJ
biomedich-819	89	26	sensitivity	sensitivity	NOUN
biomedich-819	89	27	)	)	PUNCT
biomedich-819	89	28	and	and	CCONJ
biomedich-819	89	29	minimizing	minimize	VERB
biomedich-819	89	30	off	off	ADP
biomedich-819	89	31	-	-	PUNCT
biomedich-819	89	32	target	target	NOUN
biomedich-819	89	33	effects	effect	NOUN
biomedich-819	89	34	(	(	PUNCT
biomedich-819	89	35	high	high	ADJ
biomedich-819	89	36	specificity	specificity	NOUN
biomedich-819	89	37	)	)	PUNCT
biomedich-819	89	38	(	(	PUNCT
biomedich-819	89	39	chuai	chuai	PROPN
biomedich-819	89	40	et	et	PROPN
biomedich-819	89	41	al	al	PROPN
biomedich-819	89	42	.	.	PROPN
biomedich-819	89	43	,	,	PUNCT
biomedich-819	89	44	2018	2018	NUM
biomedich-819	89	45	;	;	PUNCT
biomedich-819	89	46	chuai	chuai	PROPN
biomedich-819	89	47	et	et	PROPN
biomedich-819	89	48	al	al	PROPN
biomedich-819	89	49	.	.	PROPN
biomedich-819	89	50	,	,	PUNCT
biomedich-819	89	51	2017	2017	NUM
biomedich-819	89	52	)	)	PUNCT
biomedich-819	89	53	.	.	PUNCT
biomedich-819	90	1	the	the	DET
biomedich-819	90	2	22nd	22nd	ADJ
biomedich-819	90	3	,	,	PUNCT
biomedich-819	90	4	50th	50th	ADJ
biomedich-819	90	5	,	,	PUNCT
biomedich-819	90	6	and	and	CCONJ
biomedich-819	90	7	25th	25th	ADJ
biomedich-819	90	8	sirna	sirna	PROPN
biomedich-819	90	9	candidates	candidate	NOUN
biomedich-819	90	10	are	be	AUX
biomedich-819	90	11	among	among	ADP
biomedich-819	90	12	the	the	DET
biomedich-819	90	13	best	good	ADJ
biomedich-819	90	14	targets	target	NOUN
biomedich-819	90	15	for	for	ADP
biomedich-819	90	16	gene	gene	NOUN
biomedich-819	90	17	silencing	silence	VERB
biomedich-819	90	18	based	base	VERB
biomedich-819	90	19	on	on	ADP
biomedich-819	90	20	binding	bind	VERB
biomedich-819	90	21	strength	strength	NOUN
biomedich-819	90	22	and	and	CCONJ
biomedich-819	90	23	the	the	DET
biomedich-819	90	24	highest	high	ADJ
biomedich-819	90	25	efficacy	efficacy	NOUN
biomedich-819	90	26	predictions	prediction	NOUN
biomedich-819	90	27	of	of	ADP
biomedich-819	90	28	all	all	DET
biomedich-819	90	29	sirna	sirna	PROPN
biomedich-819	90	30	candidates	candidate	NOUN
biomedich-819	90	31	,	,	PUNCT
biomedich-819	90	32	showing	show	VERB
biomedich-819	90	33	potential	potential	NOUN
biomedich-819	90	34	to	to	PART
biomedich-819	90	35	suppress	suppress	VERB
biomedich-819	90	36	the	the	DET
biomedich-819	90	37	icad	icad	PROPN
biomedich-819	90	38	rna	rna	PROPN
biomedich-819	90	39	of	of	ADP
biomedich-819	90	40	s.	s.	PROPN
biomedich-819	90	41	aureus	aureus	PROPN
biomedich-819	90	42	effectively	effectively	ADV
biomedich-819	90	43	.	.	PUNCT
biomedich-819	91	1	sirna	sirna	PROPN
biomedich-819	91	2	with	with	ADP
biomedich-819	91	3	a	a	DET
biomedich-819	91	4	90	90	NUM
biomedich-819	91	5	%	%	NOUN
biomedich-819	91	6	inhibition	inhibition	NOUN
biomedich-819	91	7	rate	rate	NOUN
biomedich-819	91	8	demonstrates	demonstrate	VERB
biomedich-819	91	9	exceptional	exceptional	ADJ
biomedich-819	91	10	ability	ability	NOUN
biomedich-819	91	11	to	to	PART
biomedich-819	91	12	reduce	reduce	VERB
biomedich-819	91	13	target	target	NOUN
biomedich-819	91	14	gene	gene	NOUN
biomedich-819	91	15	expression	expression	NOUN
biomedich-819	91	16	efficiently	efficiently	ADV
biomedich-819	91	17	.	.	PUNCT
biomedich-819	92	1	this	this	PRON
biomedich-819	92	2	ensures	ensure	VERB
biomedich-819	92	3	that	that	SCONJ
biomedich-819	92	4	the	the	DET
biomedich-819	92	5	target	target	NOUN
biomedich-819	92	6	mrna	mrna	NOUN
biomedich-819	92	7	is	be	AUX
biomedich-819	92	8	almost	almost	ADV
biomedich-819	92	9	completely	completely	ADV
biomedich-819	92	10	inhibited	inhibit	VERB
biomedich-819	92	11	,	,	PUNCT
biomedich-819	92	12	which	which	PRON
biomedich-819	92	13	is	be	AUX
biomedich-819	92	14	crucial	crucial	ADJ
biomedich-819	92	15	in	in	ADP
biomedich-819	92	16	therapeutic	therapeutic	ADJ
biomedich-819	92	17	applications	application	NOUN
biomedich-819	92	18	or	or	CCONJ
biomedich-819	92	19	research	research	NOUN
biomedich-819	92	20	requiring	require	VERB
biomedich-819	92	21	highly	highly	ADV
biomedich-819	92	22	effective	effective	ADJ
biomedich-819	92	23	gene	gene	NOUN
biomedich-819	92	24	knockdown	knockdown	NOUN
biomedich-819	92	25	(	(	PUNCT
biomedich-819	92	26	liu	liu	PROPN
biomedich-819	92	27	et	et	PROPN
biomedich-819	92	28	al	al	PROPN
biomedich-819	92	29	.	.	PROPN
biomedich-819	92	30	,	,	PUNCT
biomedich-819	92	31	2012	2012	NUM
biomedich-819	92	32	;	;	PUNCT
biomedich-819	92	33	caffrey	caffrey	PROPN
biomedich-819	92	34	et	et	PROPN
biomedich-819	92	35	al	al	PROPN
biomedich-819	92	36	.	.	PROPN
biomedich-819	92	37	,	,	PUNCT
biomedich-819	92	38	2011	2011	NUM
biomedich-819	92	39	)	)	PUNCT
biomedich-819	92	40	.	.	PUNCT
biomedich-819	93	1	with	with	ADP
biomedich-819	93	2	high	high	ADJ
biomedich-819	93	3	efficiency	efficiency	NOUN
biomedich-819	93	4	,	,	PUNCT
biomedich-819	93	5	the	the	DET
biomedich-819	93	6	dose	dose	NOUN
biomedich-819	93	7	of	of	ADP
biomedich-819	93	8	sirna	sirna	PROPN
biomedich-819	93	9	required	require	VERB
biomedich-819	93	10	to	to	PART
biomedich-819	93	11	achieve	achieve	VERB
biomedich-819	93	12	therapeutic	therapeutic	ADJ
biomedich-819	93	13	effects	effect	NOUN
biomedich-819	93	14	can	can	AUX
biomedich-819	93	15	be	be	AUX
biomedich-819	93	16	minimized	minimize	VERB
biomedich-819	93	17	.	.	PUNCT
biomedich-819	94	1	this	this	DET
biomedich-819	94	2	reduction	reduction	NOUN
biomedich-819	94	3	in	in	ADP
biomedich-819	94	4	dose	dose	NOUN
biomedich-819	94	5	can	can	AUX
biomedich-819	94	6	decrease	decrease	VERB
biomedich-819	94	7	the	the	DET
biomedich-819	94	8	risk	risk	NOUN
biomedich-819	94	9	of	of	ADP
biomedich-819	94	10	side	side	NOUN
biomedich-819	94	11	effects	effect	NOUN
biomedich-819	94	12	,	,	PUNCT
biomedich-819	94	13	such	such	ADJ
biomedich-819	94	14	as	as	ADP
biomedich-819	94	15	immune	immune	ADJ
biomedich-819	94	16	response	response	NOUN
biomedich-819	94	17	activation	activation	NOUN
biomedich-819	94	18	or	or	CCONJ
biomedich-819	94	19	off	off	ADP
biomedich-819	94	20	-	-	PUNCT
biomedich-819	94	21	target	target	NOUN
biomedich-819	94	22	effects	effect	NOUN
biomedich-819	94	23	,	,	PUNCT
biomedich-819	94	24	which	which	PRON
biomedich-819	94	25	are	be	AUX
biomedich-819	94	26	often	often	ADV
biomedich-819	94	27	associated	associate	VERB
biomedich-819	94	28	with	with	ADP
biomedich-819	94	29	higher	high	ADJ
biomedich-819	94	30	sirna	sirna	PROPN
biomedich-819	94	31	doses	dose	NOUN
biomedich-819	94	32	(	(	PUNCT
biomedich-819	94	33	caffrey	caffrey	PROPN
biomedich-819	94	34	et	et	PROPN
biomedich-819	94	35	al	al	PROPN
biomedich-819	94	36	.	.	PROPN
biomedich-819	94	37	,	,	PUNCT
biomedich-819	94	38	2011	2011	NUM
biomedich-819	94	39	)	)	PUNCT
biomedich-819	94	40	.	.	PUNCT
biomedich-819	95	1	sirna	sirna	PROPN
biomedich-819	95	2	with	with	ADP
biomedich-819	95	3	high	high	ADJ
biomedich-819	95	4	inhibition	inhibition	NOUN
biomedich-819	95	5	levels	level	NOUN
biomedich-819	95	6	typically	typically	ADV
biomedich-819	95	7	have	have	VERB
biomedich-819	95	8	a	a	DET
biomedich-819	95	9	strong	strong	ADJ
biomedich-819	95	10	binding	bind	VERB
biomedich-819	95	11	affinity	affinity	NOUN
biomedich-819	95	12	to	to	ADP
biomedich-819	95	13	the	the	DET
biomedich-819	95	14	target	target	NOUN
biomedich-819	95	15	mrna	mrna	PROPN
biomedich-819	95	16	.	.	PUNCT
biomedich-819	96	1	this	this	DET
biomedich-819	96	2	strong	strong	ADJ
biomedich-819	96	3	affinity	affinity	NOUN
biomedich-819	96	4	ensures	ensure	VERB
biomedich-819	96	5	that	that	SCONJ
biomedich-819	96	6	,	,	PUNCT
biomedich-819	96	7	even	even	ADV
biomedich-819	96	8	with	with	ADP
biomedich-819	96	9	a	a	DET
biomedich-819	96	10	smaller	small	ADJ
biomedich-819	96	11	amount	amount	NOUN
biomedich-819	96	12	of	of	ADP
biomedich-819	96	13	sirna	sirna	PROPN
biomedich-819	96	14	,	,	PUNCT
biomedich-819	96	15	binding	bind	VERB
biomedich-819	96	16	to	to	ADP
biomedich-819	96	17	the	the	DET
biomedich-819	96	18	target	target	NOUN
biomedich-819	96	19	remains	remain	VERB
biomedich-819	96	20	efficient	efficient	ADJ
biomedich-819	96	21	,	,	PUNCT
biomedich-819	96	22	allowing	allow	VERB
biomedich-819	96	23	for	for	ADP
biomedich-819	96	24	optimal	optimal	ADJ
biomedich-819	96	25	gene	gene	NOUN
biomedich-819	96	26	knockdown	knockdown	NOUN
biomedich-819	96	27	.	.	PUNCT
biomedich-819	97	1	in	in	ADP
biomedich-819	97	2	a	a	DET
biomedich-819	97	3	clinical	clinical	ADJ
biomedich-819	97	4	context	context	NOUN
biomedich-819	97	5	,	,	PUNCT
biomedich-819	97	6	the	the	DET
biomedich-819	97	7	ability	ability	NOUN
biomedich-819	97	8	to	to	PART
biomedich-819	97	9	achieve	achieve	VERB
biomedich-819	97	10	near	near	ADV
biomedich-819	97	11	-	-	PUNCT
biomedich-819	97	12	perfect	perfect	ADJ
biomedich-819	97	13	knockdown	knockdown	NOUN
biomedich-819	97	14	provides	provide	VERB
biomedich-819	97	15	greater	great	ADJ
biomedich-819	97	16	confidence	confidence	NOUN
biomedich-819	97	17	in	in	ADP
biomedich-819	97	18	the	the	DET
biomedich-819	97	19	sulistina	sulistina	PROPN
biomedich-819	97	20	et	et	PROPN
biomedich-819	97	21	al	al	PROPN
biomedich-819	97	22	.	.	PROPN
biomedich-819	97	23	–	–	PUNCT
biomedich-819	97	24	sirnas	sirna	NOUN
biomedich-819	97	25	targeting	target	VERB
biomedich-819	97	26	icad	icad	ADJ
biomedich-819	97	27	gene	gene	NOUN
biomedich-819	97	28	of	of	ADP
biomedich-819	97	29	staphylococcus	staphylococcus	NOUN
biomedich-819	97	30	aureus	aureus	NOUN
biomedich-819	97	31	to	to	PART
biomedich-819	97	32	inhibit	inhibit	VERB
biomedich-819	97	33	biofilm	biofilm	NOUN
biomedich-819	97	34	925	925	NUM
biomedich-819	97	35	effectiveness	effectiveness	NOUN
biomedich-819	97	36	of	of	ADP
biomedich-819	97	37	sirna	sirna	PROPN
biomedich-819	97	38	as	as	ADP
biomedich-819	97	39	a	a	DET
biomedich-819	97	40	therapy	therapy	NOUN
biomedich-819	97	41	.	.	PUNCT
biomedich-819	98	1	this	this	PRON
biomedich-819	98	2	is	be	AUX
biomedich-819	98	3	especially	especially	ADV
biomedich-819	98	4	important	important	ADJ
biomedich-819	98	5	for	for	ADP
biomedich-819	98	6	diseases	disease	NOUN
biomedich-819	98	7	that	that	PRON
biomedich-819	98	8	require	require	VERB
biomedich-819	98	9	drastic	drastic	ADJ
biomedich-819	98	10	inhibition	inhibition	NOUN
biomedich-819	98	11	of	of	ADP
biomedich-819	98	12	the	the	DET
biomedich-819	98	13	target	target	NOUN
biomedich-819	98	14	gene	gene	NOUN
biomedich-819	98	15	,	,	PUNCT
biomedich-819	98	16	such	such	ADJ
biomedich-819	98	17	as	as	ADP
biomedich-819	98	18	cancer	cancer	NOUN
biomedich-819	98	19	or	or	CCONJ
biomedich-819	98	20	chronic	chronic	ADJ
biomedich-819	98	21	infections	infection	NOUN
biomedich-819	98	22	(	(	PUNCT
biomedich-819	98	23	liu	liu	PROPN
biomedich-819	98	24	et	et	PROPN
biomedich-819	98	25	al	al	PROPN
biomedich-819	98	26	.	.	PROPN
biomedich-819	98	27	,	,	PUNCT
biomedich-819	98	28	2012	2012	NUM
biomedich-819	98	29	)	)	PUNCT
biomedich-819	98	30	.	.	PUNCT
biomedich-819	99	1	the	the	DET
biomedich-819	99	2	application	application	NOUN
biomedich-819	99	3	of	of	ADP
biomedich-819	99	4	gene	gene	NOUN
biomedich-819	99	5	silencing	silence	VERB
biomedich-819	99	6	based	base	VERB
biomedich-819	99	7	on	on	ADP
biomedich-819	99	8	sirna	sirna	PROPN
biomedich-819	99	9	technology	technology	PROPN
biomedich-819	99	10	is	be	AUX
biomedich-819	99	11	a	a	DET
biomedich-819	99	12	powerful	powerful	ADJ
biomedich-819	99	13	strategy	strategy	NOUN
biomedich-819	99	14	to	to	PART
biomedich-819	99	15	limit	limit	VERB
biomedich-819	99	16	bacterial	bacterial	ADJ
biomedich-819	99	17	infections	infection	NOUN
biomedich-819	99	18	by	by	ADP
biomedich-819	99	19	targeting	target	VERB
biomedich-819	99	20	and	and	CCONJ
biomedich-819	99	21	degrading	degrade	VERB
biomedich-819	99	22	bacterial	bacterial	ADJ
biomedich-819	99	23	mrna	mrna	NOUN
biomedich-819	99	24	,	,	PUNCT
biomedich-819	99	25	ensuring	ensure	VERB
biomedich-819	99	26	that	that	SCONJ
biomedich-819	99	27	its	its	PRON
biomedich-819	99	28	sequence	sequence	NOUN
biomedich-819	99	29	matches	match	VERB
biomedich-819	99	30	the	the	DET
biomedich-819	99	31	target	target	NOUN
biomedich-819	99	32	(	(	PUNCT
biomedich-819	99	33	hartawan	hartawan	PROPN
biomedich-819	99	34	et	et	PROPN
biomedich-819	99	35	al	al	PROPN
biomedich-819	99	36	.	.	PROPN
biomedich-819	99	37	,	,	PUNCT
biomedich-819	99	38	2022	2022	NUM
biomedich-819	99	39	)	)	PUNCT
biomedich-819	99	40	.	.	PUNCT
biomedich-819	100	1	bacteria	bacteria	NOUN
biomedich-819	100	2	like	like	ADP
biomedich-819	100	3	s.	s.	PROPN
biomedich-819	100	4	aureus	aureus	PROPN
biomedich-819	100	5	have	have	AUX
biomedich-819	100	6	undergone	undergo	VERB
biomedich-819	100	7	many	many	ADJ
biomedich-819	100	8	mutations	mutation	NOUN
biomedich-819	100	9	over	over	ADP
biomedich-819	100	10	time	time	NOUN
biomedich-819	100	11	.	.	PUNCT
biomedich-819	101	1	therefore	therefore	ADV
biomedich-819	101	2	,	,	PUNCT
biomedich-819	101	3	sirna	sirna	PROPN
biomedich-819	101	4	for	for	ADP
biomedich-819	101	5	bacteria	bacteria	NOUN
biomedich-819	101	6	must	must	AUX
biomedich-819	101	7	be	be	AUX
biomedich-819	101	8	targeted	target	VERB
biomedich-819	101	9	at	at	ADP
biomedich-819	101	10	genes	gene	NOUN
biomedich-819	101	11	that	that	PRON
biomedich-819	101	12	are	be	AUX
biomedich-819	101	13	considered	consider	VERB
biomedich-819	101	14	to	to	PART
biomedich-819	101	15	have	have	VERB
biomedich-819	101	16	an	an	DET
biomedich-819	101	17	impact	impact	NOUN
biomedich-819	101	18	on	on	ADP
biomedich-819	101	19	infection	infection	NOUN
biomedich-819	101	20	.	.	PUNCT
biomedich-819	102	1	the	the	DET
biomedich-819	102	2	icad	icad	PROPN
biomedich-819	102	3	gene	gene	NOUN
biomedich-819	102	4	is	be	AUX
biomedich-819	102	5	a	a	DET
biomedich-819	102	6	promising	promising	ADJ
biomedich-819	102	7	target	target	NOUN
biomedich-819	102	8	for	for	ADP
biomedich-819	102	9	gene	gene	NOUN
biomedich-819	102	10	silencing	silence	VERB
biomedich-819	102	11	because	because	SCONJ
biomedich-819	102	12	it	it	PRON
biomedich-819	102	13	is	be	AUX
biomedich-819	102	14	located	locate	VERB
biomedich-819	102	15	within	within	ADP
biomedich-819	102	16	the	the	DET
biomedich-819	102	17	biofilm	biofilm	NOUN
biomedich-819	102	18	structure	structure	NOUN
biomedich-819	102	19	of	of	ADP
biomedich-819	102	20	s.	s.	PROPN
biomedich-819	102	21	aureus	aureus	PROPN
biomedich-819	102	22	,	,	PUNCT
biomedich-819	102	23	which	which	PRON
biomedich-819	102	24	plays	play	VERB
biomedich-819	102	25	an	an	DET
biomedich-819	102	26	important	important	ADJ
biomedich-819	102	27	role	role	NOUN
biomedich-819	102	28	in	in	ADP
biomedich-819	102	29	the	the	DET
biomedich-819	102	30	virulence	virulence	NOUN
biomedich-819	102	31	factors	factor	NOUN
biomedich-819	102	32	of	of	ADP
biomedich-819	102	33	an	an	DET
biomedich-819	102	34	infectious	infectious	ADJ
biomedich-819	102	35	disease	disease	NOUN
biomedich-819	102	36	.	.	PUNCT
biomedich-819	103	1	conclusions	conclusion	NOUN
biomedich-819	103	2	based	base	VERB
biomedich-819	103	3	on	on	ADP
biomedich-819	103	4	the	the	DET
biomedich-819	103	5	results	result	NOUN
biomedich-819	103	6	of	of	ADP
biomedich-819	103	7	the	the	DET
biomedich-819	103	8	bioinformatics	bioinformatics	NOUN
biomedich-819	103	9	study	study	NOUN
biomedich-819	103	10	on	on	ADP
biomedich-819	103	11	the	the	DET
biomedich-819	103	12	exploration	exploration	NOUN
biomedich-819	103	13	,	,	PUNCT
biomedich-819	103	14	structure	structure	NOUN
biomedich-819	103	15	,	,	PUNCT
biomedich-819	103	16	and	and	CCONJ
biomedich-819	103	17	efficacy	efficacy	NOUN
biomedich-819	103	18	prediction	prediction	NOUN
biomedich-819	103	19	of	of	ADP
biomedich-819	103	20	sirna	sirna	PROPN
biomedich-819	103	21	icad	icad	PROPN
biomedich-819	103	22	interacting	interact	VERB
biomedich-819	103	23	with	with	ADP
biomedich-819	103	24	icad	icad	PROPN
biomedich-819	103	25	rna	rna	PROPN
biomedich-819	103	26	in	in	ADP
biomedich-819	103	27	s.	s.	PROPN
biomedich-819	103	28	aureus	aureus	PROPN
biomedich-819	103	29	bacteria	bacteria	NOUN
biomedich-819	103	30	,	,	PUNCT
biomedich-819	103	31	this	this	DET
biomedich-819	103	32	study	study	NOUN
biomedich-819	103	33	found	find	VERB
biomedich-819	103	34	the	the	DET
biomedich-819	103	35	binding	bind	VERB
biomedich-819	103	36	energy	energy	NOUN
biomedich-819	103	37	and	and	CCONJ
biomedich-819	103	38	inhibition	inhibition	NOUN
biomedich-819	103	39	capability	capability	NOUN
biomedich-819	103	40	of	of	ADP
biomedich-819	103	41	sirna	sirna	PROPN
biomedich-819	103	42	in	in	ADP
biomedich-819	103	43	silencing	silence	VERB
biomedich-819	103	44	the	the	DET
biomedich-819	103	45	icad	icad	ADJ
biomedich-819	103	46	gene	gene	NOUN
biomedich-819	103	47	.	.	PUNCT
biomedich-819	104	1	the	the	DET
biomedich-819	104	2	best	good	ADJ
biomedich-819	104	3	results	result	NOUN
biomedich-819	104	4	were	be	AUX
biomedich-819	104	5	obtained	obtain	VERB
biomedich-819	104	6	with	with	ADP
biomedich-819	104	7	sirna	sirna	PROPN
biomedich-819	104	8	strands	strand	VERB
biomedich-819	104	9	22	22	NUM
biomedich-819	104	10	,	,	PUNCT
biomedich-819	104	11	50	50	NUM
biomedich-819	104	12	,	,	PUNCT
biomedich-819	104	13	and	and	CCONJ
biomedich-819	104	14	25	25	NUM
biomedich-819	104	15	,	,	PUNCT
biomedich-819	104	16	which	which	PRON
biomedich-819	104	17	resulted	result	VERB
biomedich-819	104	18	in	in	ADP
biomedich-819	104	19	inhibition	inhibition	NOUN
biomedich-819	104	20	of	of	ADP
biomedich-819	104	21	93.69	93.69	NUM
biomedich-819	104	22	%	%	NOUN
biomedich-819	104	23	,	,	PUNCT
biomedich-819	104	24	92.82	92.82	NUM
biomedich-819	104	25	%	%	NOUN
biomedich-819	104	26	,	,	PUNCT
biomedich-819	104	27	and	and	CCONJ
biomedich-819	104	28	92.52	92.52	NUM
biomedich-819	104	29	%	%	NOUN
biomedich-819	104	30	,	,	PUNCT
biomedich-819	104	31	respectively	respectively	ADV
biomedich-819	104	32	.	.	PUNCT
biomedich-819	105	1	sirna	sirna	PROPN
biomedich-819	105	2	with	with	ADP
biomedich-819	105	3	high	high	ADJ
biomedich-819	105	4	inhibition	inhibition	NOUN
biomedich-819	105	5	levels	level	NOUN
biomedich-819	105	6	typically	typically	ADV
biomedich-819	105	7	has	have	VERB
biomedich-819	105	8	a	a	DET
biomedich-819	105	9	strong	strong	ADJ
biomedich-819	105	10	binding	bind	VERB
biomedich-819	105	11	affinity	affinity	NOUN
biomedich-819	105	12	to	to	ADP
biomedich-819	105	13	the	the	DET
biomedich-819	105	14	target	target	NOUN
biomedich-819	105	15	mrna	mrna	PROPN
biomedich-819	105	16	.	.	PUNCT
biomedich-819	106	1	this	this	DET
biomedich-819	106	2	strong	strong	ADJ
biomedich-819	106	3	affinity	affinity	NOUN
biomedich-819	106	4	ensures	ensure	VERB
biomedich-819	106	5	that	that	SCONJ
biomedich-819	106	6	,	,	PUNCT
biomedich-819	106	7	even	even	ADV
biomedich-819	106	8	with	with	ADP
biomedich-819	106	9	a	a	DET
biomedich-819	106	10	smaller	small	ADJ
biomedich-819	106	11	amount	amount	NOUN
biomedich-819	106	12	of	of	ADP
biomedich-819	106	13	sirna	sirna	PROPN
biomedich-819	106	14	,	,	PUNCT
biomedich-819	106	15	binding	bind	VERB
biomedich-819	106	16	to	to	ADP
biomedich-819	106	17	the	the	DET
biomedich-819	106	18	target	target	NOUN
biomedich-819	106	19	remains	remain	VERB
biomedich-819	106	20	efficient	efficient	ADJ
biomedich-819	106	21	,	,	PUNCT
biomedich-819	106	22	leading	lead	VERB
biomedich-819	106	23	to	to	ADP
biomedich-819	106	24	optimal	optimal	ADJ
biomedich-819	106	25	gene	gene	NOUN
biomedich-819	106	26	knockdown	knockdown	NOUN
biomedich-819	106	27	.	.	PUNCT
biomedich-819	107	1	these	these	DET
biomedich-819	107	2	three	three	NUM
biomedich-819	107	3	potential	potential	ADJ
biomedich-819	107	4	sirna	sirna	PROPN
biomedich-819	107	5	molecules	molecule	NOUN
biomedich-819	107	6	can	can	AUX
biomedich-819	107	7	be	be	AUX
biomedich-819	107	8	used	use	VERB
biomedich-819	107	9	as	as	ADP
biomedich-819	107	10	an	an	DET
biomedich-819	107	11	sirna	sirna	PROPN
biomedich-819	107	12	-	-	PUNCT
biomedich-819	107	13	based	base	VERB
biomedich-819	107	14	antibacterial	antibacterial	ADJ
biomedich-819	107	15	therapy	therapy	NOUN
biomedich-819	107	16	to	to	PART
biomedich-819	107	17	suppress	suppress	VERB
biomedich-819	107	18	infections	infection	NOUN
biomedich-819	107	19	caused	cause	VERB
biomedich-819	107	20	by	by	ADP
biomedich-819	107	21	staphylococcus	staphylococcus	NOUN
biomedich-819	107	22	aureus	aureus	NOUN
biomedich-819	107	23	with	with	ADP
biomedich-819	107	24	biofilms	biofilm	NOUN
biomedich-819	107	25	.	.	PUNCT
biomedich-819	108	1	however	however	ADV
biomedich-819	108	2	,	,	PUNCT
biomedich-819	108	3	the	the	DET
biomedich-819	108	4	sirna	sirna	PROPN
biomedich-819	108	5	predictions	prediction	NOUN
biomedich-819	108	6	in	in	ADP
biomedich-819	108	7	this	this	DET
biomedich-819	108	8	study	study	NOUN
biomedich-819	108	9	are	be	AUX
biomedich-819	108	10	important	important	ADJ
biomedich-819	108	11	to	to	PART
biomedich-819	108	12	validate	validate	VERB
biomedich-819	108	13	through	through	ADP
biomedich-819	108	14	laboratory	laboratory	NOUN
biomedich-819	108	15	experiments	experiment	NOUN
biomedich-819	108	16	.	.	PUNCT
biomedich-819	109	1	acknowledgements	acknowledgement	NOUN
biomedich-819	109	2	:	:	PUNCT
biomedich-819	109	3	the	the	DET
biomedich-819	109	4	authors	author	NOUN
biomedich-819	109	5	would	would	AUX
biomedich-819	109	6	like	like	VERB
biomedich-819	109	7	to	to	PART
biomedich-819	109	8	thank	thank	VERB
biomedich-819	109	9	to	to	ADP
biomedich-819	109	10	the	the	DET
biomedich-819	109	11	faculty	faculty	NOUN
biomedich-819	109	12	of	of	ADP
biomedich-819	109	13	medical	medical	ADJ
biomedich-819	109	14	,	,	PUNCT
biomedich-819	109	15	palangka	palangka	PROPN
biomedich-819	109	16	raya	raya	PROPN
biomedich-819	109	17	university	university	PROPN
biomedich-819	109	18	,	,	PUNCT
biomedich-819	109	19	central	central	ADJ
biomedich-819	109	20	kalimantan	kalimantan	PROPN
biomedich-819	109	21	,	,	PUNCT
biomedich-819	109	22	for	for	ADP
biomedich-819	109	23	providing	provide	VERB
biomedich-819	109	24	valuable	valuable	ADJ
biomedich-819	109	25	resources	resource	NOUN
biomedich-819	109	26	that	that	PRON
biomedich-819	109	27	facilitated	facilitate	VERB
biomedich-819	109	28	a	a	DET
biomedich-819	109	29	deeper	deep	ADJ
biomedich-819	109	30	understanding	understanding	NOUN
biomedich-819	109	31	of	of	ADP
biomedich-819	109	32	sirna	sirna	PROPN
biomedich-819	109	33	for	for	ADP
biomedich-819	109	34	therapeutic	therapeutic	ADJ
biomedich-819	109	35	purposes	purpose	NOUN
biomedich-819	109	36	.	.	PUNCT
biomedich-819	110	1	authors	author	NOUN
biomedich-819	110	2	’	'	PUNCT
biomedich-819	110	3	contributions	contribution	NOUN
biomedich-819	110	4	:	:	PUNCT
biomedich-819	110	5	study	study	NOUN
biomedich-819	110	6	concept	concept	NOUN
biomedich-819	110	7	and	and	CCONJ
biomedich-819	110	8	design	design	NOUN
biomedich-819	110	9	d.a.s	d.a.s	PROPN
biomedich-819	110	10	.	.	PROPN
biomedich-819	110	11	,	,	PUNCT
biomedich-819	110	12	r.k.p	r.k.p	NOUN
biomedich-819	110	13	.	.	PUNCT
biomedich-819	110	14	,	,	PUNCT
biomedich-819	110	15	and	and	CCONJ
biomedich-819	110	16	m.y.i.a	m.y.i.a	PROPN
biomedich-819	110	17	.	.	PROPN
biomedich-819	110	18	;	;	PUNCT
biomedich-819	110	19	data	datum	NOUN
biomedich-819	110	20	acquisition	acquisition	NOUN
biomedich-819	110	21	d.a.s	d.a.s	PROPN
biomedich-819	110	22	.	.	PUNCT
biomedich-819	111	1	and	and	CCONJ
biomedich-819	111	2	r.k.p	r.k.p	NOUN
biomedich-819	111	3	;	;	PUNCT
biomedich-819	111	4	analysis	analysis	NOUN
biomedich-819	111	5	and	and	CCONJ
biomedich-819	111	6	interpretation	interpretation	NOUN
biomedich-819	111	7	of	of	ADP
biomedich-819	111	8	data	datum	NOUN
biomedich-819	111	9	d.a.s	d.a.s	PROPN
biomedich-819	111	10	;	;	PUNCT
biomedich-819	111	11	drafting	draft	VERB
biomedich-819	111	12	of	of	ADP
biomedich-819	111	13	the	the	DET
biomedich-819	111	14	manuscript	manuscript	NOUN
biomedich-819	111	15	d.a.s	d.a.s	PROPN
biomedich-819	111	16	.	.	PROPN
biomedich-819	111	17	,	,	PUNCT
biomedich-819	111	18	critical	critical	ADJ
biomedich-819	111	19	revision	revision	NOUN
biomedich-819	111	20	of	of	ADP
biomedich-819	111	21	the	the	DET
biomedich-819	111	22	manuscript	manuscript	NOUN
biomedich-819	111	23	d.a.s	d.a.s	PROPN
biomedich-819	111	24	.	.	PROPN
biomedich-819	111	25	,	,	PUNCT
biomedich-819	111	26	r.k.p	r.k.p	PROPN
biomedich-819	111	27	.	.	PUNCT
biomedich-819	111	28	,	,	PUNCT
biomedich-819	111	29	m.y.i.a	m.y.i.a	PROPN
biomedich-819	111	30	.	.	PROPN
biomedich-819	111	31	,	,	PUNCT
biomedich-819	111	32	h.	h.	PROPN
biomedich-819	111	33	,	,	PUNCT
biomedich-819	111	34	and	and	CCONJ
biomedich-819	111	35	y.	y.	NOUN
biomedich-819	111	36	;	;	PUNCT
biomedich-819	111	37	administrative	administrative	ADJ
biomedich-819	111	38	,	,	PUNCT
biomedich-819	111	39	technical	technical	ADJ
biomedich-819	111	40	,	,	PUNCT
biomedich-819	111	41	and	and	CCONJ
biomedich-819	111	42	material	material	NOUN
biomedich-819	111	43	support	support	NOUN
biomedich-819	111	44	r.k.p	r.k.p	NOUN
biomedich-819	111	45	.	.	PUNCT
biomedich-819	111	46	;	;	PUNCT
biomedich-819	111	47	study	study	NOUN
biomedich-819	111	48	supervision	supervision	NOUN
biomedich-819	111	49	r.k.p	r.k.p	NOUN
biomedich-819	111	50	.	.	PUNCT
biomedich-819	111	51	,	,	PUNCT
biomedich-819	111	52	m.y.i.a	m.y.i.a	PROPN
biomedich-819	111	53	.	.	PROPN
biomedich-819	111	54	,	,	PUNCT
biomedich-819	111	55	h	h	NOUN
biomedich-819	111	56	,	,	PUNCT
biomedich-819	111	57	and	and	CCONJ
biomedich-819	111	58	y.	y.	NOUN
biomedich-819	111	59	competing	compete	VERB
biomedich-819	111	60	interests	interest	NOUN
biomedich-819	111	61	:	:	PUNCT
biomedich-819	111	62	the	the	DET
biomedich-819	111	63	authors	author	NOUN
biomedich-819	111	64	declare	declare	VERB
biomedich-819	111	65	that	that	SCONJ
biomedich-819	111	66	there	there	PRON
biomedich-819	111	67	are	be	VERB
biomedich-819	111	68	no	no	DET
biomedich-819	111	69	competing	compete	VERB
biomedich-819	111	70	interests	interest	NOUN
biomedich-819	111	71	.	.	PUNCT
biomedich-819	112	1	funding	funding	NOUN
biomedich-819	112	2	:	:	PUNCT
biomedich-819	112	3	the	the	DET
biomedich-819	112	4	authors	author	NOUN
biomedich-819	112	5	declare	declare	VERB
biomedich-819	112	6	that	that	SCONJ
biomedich-819	112	7	no	no	DET
biomedich-819	112	8	funding	funding	NOUN
biomedich-819	112	9	was	be	AUX
biomedich-819	112	10	received	receive	VERB
biomedich-819	112	11	for	for	ADP
biomedich-819	112	12	this	this	DET
biomedich-819	112	13	study	study	NOUN
biomedich-819	112	14	.	.	PUNCT
biomedich-819	113	1	references	reference	NOUN
biomedich-819	113	2	angart	angart	ADJ
biomedich-819	113	3	,	,	PUNCT
biomedich-819	113	4	p.	p.	PROPN
biomedich-819	113	5	,	,	PUNCT
biomedich-819	113	6	vocelle	vocelle	PROPN
biomedich-819	113	7	,	,	PUNCT
biomedich-819	113	8	d.	d.	PROPN
biomedich-819	113	9	,	,	PUNCT
biomedich-819	113	10	chan	chan	PROPN
biomedich-819	113	11	,	,	PUNCT
biomedich-819	113	12	c.	c.	PROPN
biomedich-819	113	13	,	,	PUNCT
biomedich-819	113	14	&	&	CCONJ
biomedich-819	113	15	patrick	patrick	PROPN
biomedich-819	113	16	walton	walton	PROPN
biomedich-819	113	17	,	,	PUNCT
biomedich-819	113	18	s.	s.	PROPN
biomedich-819	113	19	(	(	PUNCT
biomedich-819	113	20	2013	2013	NUM
biomedich-819	113	21	)	)	PUNCT
biomedich-819	113	22	.	.	PUNCT
biomedich-819	114	1	design	design	NOUN
biomedich-819	114	2	of	of	ADP
biomedich-819	114	3	sirna	sirna	PROPN
biomedich-819	114	4	therapeutics	therapeutic	NOUN
biomedich-819	114	5	from	from	ADP
biomedich-819	114	6	the	the	DET
biomedich-819	114	7	molecular	molecular	ADJ
biomedich-819	114	8	scale	scale	NOUN
biomedich-819	114	9	.	.	PUNCT
biomedich-819	115	1	pharmaceuticals	pharmaceutical	NOUN
biomedich-819	115	2	,	,	PUNCT
biomedich-819	115	3	6(4	6(4	NUM
biomedich-819	115	4	)	)	PUNCT
biomedich-819	115	5	,	,	PUNCT
biomedich-819	115	6	440–468	440–468	NUM
biomedich-819	115	7	.	.	PUNCT
biomedich-819	116	1	https://doi.org/10.3390/ph6040440	https://doi.org/10.3390/ph6040440	NUM
biomedich-819	116	2	caffrey	caffrey	PROPN
biomedich-819	116	3	,	,	PUNCT
biomedich-819	116	4	d.	d.	PROPN
biomedich-819	116	5	r.	r.	PROPN
biomedich-819	116	6	,	,	PUNCT
biomedich-819	116	7	zhao	zhao	PROPN
biomedich-819	116	8	,	,	PUNCT
biomedich-819	116	9	j.	j.	PROPN
biomedich-819	116	10	,	,	PUNCT
biomedich-819	116	11	song	song	PROPN
biomedich-819	116	12	,	,	PUNCT
biomedich-819	116	13	z.	z.	PROPN
biomedich-819	116	14	,	,	PUNCT
biomedich-819	116	15	schaffer	schaffer	PROPN
biomedich-819	116	16	,	,	PUNCT
biomedich-819	116	17	m.	m.	PROPN
biomedich-819	116	18	e.	e.	PROPN
biomedich-819	116	19	,	,	PUNCT
biomedich-819	116	20	haney	haney	PROPN
biomedich-819	116	21	,	,	PUNCT
biomedich-819	116	22	s.	s.	PROPN
biomedich-819	116	23	a.	a.	PROPN
biomedich-819	116	24	,	,	PUNCT
biomedich-819	116	25	subramanian	subramanian	PROPN
biomedich-819	116	26	,	,	PUNCT
biomedich-819	116	27	r.	r.	PROPN
biomedich-819	116	28	r.	r.	PROPN
biomedich-819	116	29	,	,	PUNCT
biomedich-819	116	30	seymour	seymour	PROPN
biomedich-819	116	31	,	,	PUNCT
biomedich-819	116	32	a.	a.	PROPN
biomedich-819	116	33	b.	b.	PROPN
biomedich-819	116	34	,	,	PUNCT
biomedich-819	116	35	&	&	CCONJ
biomedich-819	116	36	hughes	hughes	PROPN
biomedich-819	116	37	,	,	PUNCT
biomedich-819	116	38	j.	j.	PROPN
biomedich-819	116	39	d.	d.	PROPN
biomedich-819	116	40	(	(	PUNCT
biomedich-819	116	41	2011	2011	NUM
biomedich-819	116	42	)	)	PUNCT
biomedich-819	116	43	.	.	PUNCT
biomedich-819	117	1	sirna	sirna	PROPN
biomedich-819	117	2	off	off	ADP
biomedich-819	117	3	-	-	PUNCT
biomedich-819	117	4	target	target	NOUN
biomedich-819	117	5	effects	effect	NOUN
biomedich-819	117	6	can	can	AUX
biomedich-819	117	7	be	be	AUX
biomedich-819	117	8	reduced	reduce	VERB
biomedich-819	117	9	at	at	ADP
biomedich-819	117	10	concentrations	concentration	NOUN
biomedich-819	117	11	that	that	PRON
biomedich-819	117	12	match	match	VERB
biomedich-819	117	13	their	their	PRON
biomedich-819	117	14	individual	individual	ADJ
biomedich-819	117	15	potency	potency	NOUN
biomedich-819	117	16	.	.	PUNCT
biomedich-819	118	1	plos	plos	PROPN
biomedich-819	118	2	one	one	NUM
biomedich-819	118	3	,	,	PUNCT
biomedich-819	118	4	6(7	6(7	NUM
biomedich-819	118	5	)	)	PUNCT
biomedich-819	118	6	.	.	PUNCT
biomedich-819	119	1	https://doi.org/10.1371/journal.pone.0021503	https://doi.org/10.1371/journal.pone.0021503	PROPN
biomedich-819	119	2	chuai	chuai	PROPN
biomedich-819	119	3	,	,	PUNCT
biomedich-819	119	4	g.	g.	PROPN
biomedich-819	119	5	,	,	PUNCT
biomedich-819	119	6	ma	ma	PROPN
biomedich-819	119	7	,	,	PUNCT
biomedich-819	119	8	h.	h.	PROPN
biomedich-819	119	9	,	,	PUNCT
biomedich-819	119	10	yan	yan	PROPN
biomedich-819	119	11	,	,	PUNCT
biomedich-819	119	12	j.	j.	PROPN
biomedich-819	119	13	,	,	PUNCT
biomedich-819	119	14	chen	chen	PROPN
biomedich-819	119	15	,	,	PUNCT
biomedich-819	119	16	m.	m.	NOUN
biomedich-819	119	17	,	,	PUNCT
biomedich-819	119	18	hong	hong	PROPN
biomedich-819	119	19	,	,	PUNCT
biomedich-819	119	20	n.	n.	PROPN
biomedich-819	119	21	,	,	PUNCT
biomedich-819	119	22	xue	xue	PROPN
biomedich-819	119	23	,	,	PUNCT
biomedich-819	119	24	d.	d.	PROPN
biomedich-819	119	25	,	,	PUNCT
biomedich-819	119	26	zhou	zhou	PROPN
biomedich-819	119	27	,	,	PUNCT
biomedich-819	119	28	c.	c.	PROPN
biomedich-819	119	29	,	,	PUNCT
biomedich-819	119	30	zhu	zhu	PROPN
biomedich-819	119	31	,	,	PUNCT
biomedich-819	119	32	c.	c.	PROPN
biomedich-819	119	33	,	,	PUNCT
biomedich-819	119	34	chen	chen	PROPN
biomedich-819	119	35	,	,	PUNCT
biomedich-819	119	36	k.	k.	PROPN
biomedich-819	119	37	,	,	PUNCT
biomedich-819	119	38	duan	duan	PROPN
biomedich-819	119	39	,	,	PUNCT
biomedich-819	119	40	b.	b.	PROPN
biomedich-819	119	41	,	,	PUNCT
biomedich-819	119	42	gu	gu	PROPN
biomedich-819	119	43	,	,	PUNCT
biomedich-819	119	44	f.	f.	PROPN
biomedich-819	119	45	,	,	PUNCT
biomedich-819	119	46	qu	qu	PROPN
biomedich-819	119	47	,	,	PUNCT
biomedich-819	119	48	s.	s.	PROPN
biomedich-819	119	49	,	,	PUNCT
biomedich-819	119	50	huang	huang	PROPN
biomedich-819	119	51	,	,	PUNCT
biomedich-819	119	52	d.	d.	PROPN
biomedich-819	119	53	,	,	PUNCT
biomedich-819	119	54	wei	wei	PROPN
biomedich-819	119	55	,	,	PUNCT
biomedich-819	119	56	j.	j.	PROPN
biomedich-819	119	57	,	,	PUNCT
biomedich-819	119	58	&	&	CCONJ
biomedich-819	119	59	liu	liu	PROPN
biomedich-819	119	60	,	,	PUNCT
biomedich-819	119	61	q.	q.	PROPN
biomedich-819	119	62	(	(	PUNCT
biomedich-819	119	63	2018	2018	NUM
biomedich-819	119	64	)	)	PUNCT
biomedich-819	119	65	.	.	PUNCT
biomedich-819	120	1	deepcrispr	deepcrispr	PROPN
biomedich-819	120	2	:	:	PUNCT
biomedich-819	120	3	optimized	optimize	VERB
biomedich-819	120	4	crispr	crispr	ADJ
biomedich-819	120	5	guide	guide	NOUN
biomedich-819	120	6	rna	rna	NOUN
biomedich-819	120	7	design	design	NOUN
biomedich-819	120	8	by	by	ADP
biomedich-819	120	9	deep	deep	ADJ
biomedich-819	120	10	learning	learning	NOUN
biomedich-819	120	11	.	.	PUNCT
biomedich-819	121	1	genome	genome	NOUN
biomedich-819	121	2	biology	biology	NOUN
biomedich-819	121	3	,	,	PUNCT
biomedich-819	121	4	19(1	19(1	NUM
biomedich-819	121	5	)	)	PUNCT
biomedich-819	121	6	,	,	PUNCT
biomedich-819	121	7	1–18	1–18	NUM
biomedich-819	121	8	.	.	PUNCT
biomedich-819	122	1	https://doi.org/10.1186/s13059-018-1459-4	https://doi.org/10.1186/s13059-018-1459-4	NUM
biomedich-819	122	2	chuai	chuai	PROPN
biomedich-819	122	3	,	,	PUNCT
biomedich-819	122	4	g.	g.	PROPN
biomedich-819	122	5	,	,	PUNCT
biomedich-819	122	6	wang	wang	PROPN
biomedich-819	122	7	,	,	PUNCT
biomedich-819	122	8	q.-l	q.-l	ADV
biomedich-819	122	9	.	.	PUNCT
biomedich-819	122	10	,	,	PUNCT
biomedich-819	122	11	&	&	CCONJ
biomedich-819	122	12	liu	liu	PROPN
biomedich-819	122	13	,	,	PUNCT
biomedich-819	122	14	q.	q.	PROPN
biomedich-819	122	15	(	(	PUNCT
biomedich-819	122	16	2017	2017	NUM
biomedich-819	122	17	)	)	PUNCT
biomedich-819	122	18	.	.	PUNCT
biomedich-819	123	1	in	in	ADP
biomedich-819	123	2	silico	silico	NOUN
biomedich-819	123	3	meets	meet	VERB
biomedich-819	123	4	in	in	ADP
biomedich-819	123	5	vivo	vivo	NOUN
biomedich-819	123	6	:	:	PUNCT
biomedich-819	123	7	towards	towards	ADP
biomedich-819	123	8	computational	computational	ADJ
biomedich-819	123	9	crispr	crispr	NOUN
biomedich-819	123	10	-	-	PUNCT
biomedich-819	123	11	based	base	VERB
biomedich-819	123	12	sgrna	sgrna	NOUN
biomedich-819	123	13	design	design	NOUN
biomedich-819	123	14	.	.	PUNCT
biomedich-819	124	1	trends	trend	NOUN
biomedich-819	124	2	in	in	ADP
biomedich-819	124	3	biotechnology	biotechnology	NOUN
biomedich-819	124	4	,	,	PUNCT
biomedich-819	124	5	35(1	35(1	NUM
biomedich-819	124	6	)	)	PUNCT
biomedich-819	124	7	,	,	PUNCT
biomedich-819	124	8	12–21	12–21	NUM
biomedich-819	124	9	.	.	PUNCT
biomedich-819	125	1	https://doi.org/10.1016/j.tibtech.2016.06.008	https://doi.org/10.1016/j.tibtech.2016.06.008	PROPN
biomedich-819	125	2	dana	dana	PROPN
biomedich-819	125	3	,	,	PUNCT
biomedich-819	125	4	h.	h.	PROPN
biomedich-819	125	5	,	,	PUNCT
biomedich-819	125	6	mahmoodi	mahmoodi	PROPN
biomedich-819	125	7	chalbatani	chalbatani	PROPN
biomedich-819	125	8	,	,	PUNCT
biomedich-819	125	9	g.	g.	PROPN
biomedich-819	125	10	,	,	PUNCT
biomedich-819	125	11	mahmoodzadeh	mahmoodzadeh	PROPN
biomedich-819	125	12	,	,	PUNCT
biomedich-819	125	13	h.	h.	PROPN
biomedich-819	125	14	,	,	PUNCT
biomedich-819	125	15	karimloo	karimloo	PROPN
biomedich-819	125	16	,	,	PUNCT
biomedich-819	125	17	r.	r.	PROPN
biomedich-819	125	18	,	,	PUNCT
biomedich-819	125	19	rezaiean	rezaiean	NOUN
biomedich-819	125	20	,	,	PUNCT
biomedich-819	125	21	o.	o.	PROPN
biomedich-819	125	22	,	,	PUNCT
biomedich-819	125	23	moradzadeh	moradzadeh	PROPN
biomedich-819	125	24	,	,	PUNCT
biomedich-819	125	25	a.	a.	NOUN
biomedich-819	125	26	,	,	PUNCT
biomedich-819	125	27	mehmandoost	mehmandoost	NOUN
biomedich-819	125	28	,	,	PUNCT
biomedich-819	125	29	n.	n.	NOUN
biomedich-819	125	30	,	,	PUNCT
biomedich-819	125	31	moazzen	moazzen	PROPN
biomedich-819	125	32	,	,	PUNCT
biomedich-819	125	33	f.	f.	PROPN
biomedich-819	125	34	,	,	PUNCT
biomedich-819	125	35	mazraeh	mazraeh	NOUN
biomedich-819	125	36	,	,	PUNCT
biomedich-819	125	37	a.	a.	NOUN
biomedich-819	125	38	,	,	PUNCT
biomedich-819	125	39	marmari	marmari	PROPN
biomedich-819	125	40	,	,	PUNCT
biomedich-819	125	41	v.	v.	PROPN
biomedich-819	125	42	,	,	PUNCT
biomedich-819	125	43	ebrahimi	ebrahimi	PROPN
biomedich-819	125	44	,	,	PUNCT
biomedich-819	125	45	m.	m.	NOUN
biomedich-819	125	46	,	,	PUNCT
biomedich-819	125	47	menati	menati	NOUN
biomedich-819	125	48	rashno	rashno	NOUN
biomedich-819	125	49	,	,	PUNCT
biomedich-819	125	50	m.	m.	NOUN
biomedich-819	125	51	,	,	PUNCT
biomedich-819	125	52	jan	jan	PROPN
biomedich-819	125	53	abadi	abadi	PROPN
biomedich-819	125	54	,	,	PUNCT
biomedich-819	125	55	s.	s.	PROPN
biomedich-819	125	56	,	,	PUNCT
biomedich-819	125	57	gharagouzlo	gharagouzlo	NOUN
biomedich-819	125	58	,	,	PUNCT
biomedich-819	125	59	e.	e.	PROPN
biomedich-819	125	60	,	,	PUNCT
biomedich-819	125	61	&	&	CCONJ
biomedich-819	125	62	marmari	marmari	PROPN
biomedich-819	125	63	,	,	PUNCT
biomedich-819	125	64	v.	v.	PROPN
biomedich-819	125	65	(	(	PUNCT
biomedich-819	125	66	2017	2017	NUM
biomedich-819	125	67	)	)	PUNCT
biomedich-819	125	68	.	.	PUNCT
biomedich-819	126	1	molecular	molecular	ADJ
biomedich-819	126	2	mechanisms	mechanism	NOUN
biomedich-819	126	3	and	and	CCONJ
biomedich-819	126	4	biological	biological	ADJ
biomedich-819	126	5	functions	function	NOUN
biomedich-819	126	6	of	of	ADP
biomedich-819	126	7	sirna	sirna	PROPN
biomedich-819	126	8	.	.	PUNCT
biomedich-819	127	1	international	international	ADJ
biomedich-819	127	2	journal	journal	PROPN
biomedich-819	127	3	of	of	ADP
biomedich-819	127	4	biomedical	biomedical	ADJ
biomedich-819	127	5	science	science	NOUN
biomedich-819	127	6	,	,	PUNCT
biomedich-819	127	7	13(2	13(2	PROPN
biomedich-819	127	8	)	)	PUNCT
biomedich-819	127	9	,	,	PUNCT
biomedich-819	127	10	48–57	48–57	X
biomedich-819	127	11	.	.	PUNCT
biomedich-819	128	1	www.ijbs.org	www.ijbs.org	PROPN
biomedich-819	128	2	david	david	PROPN
biomedich-819	128	3	p.	p.	PROPN
biomedich-819	128	4	bartel	bartel	PROPN
biomedich-819	128	5	,	,	PUNCT
biomedich-819	128	6	&	&	CCONJ
biomedich-819	128	7	sharp	sharp	ADJ
biomedich-819	128	8	.	.	PUNCT
biomedich-819	128	9	,	,	PUNCT
biomedich-819	128	10	p.	p.	NOUN
biomedich-819	128	11	a.	a.	NOUN
biomedich-819	128	12	(	(	PUNCT
biomedich-819	128	13	2004	2004	NUM
biomedich-819	128	14	)	)	PUNCT
biomedich-819	128	15	.	.	PUNCT
biomedich-819	129	1	rna	rna	NOUN
biomedich-819	129	2	interference	interference	NOUN
biomedich-819	129	3	:	:	PUNCT
biomedich-819	129	4	mechanism	mechanism	NOUN
biomedich-819	129	5	,	,	PUNCT
biomedich-819	129	6	biology	biology	NOUN
biomedich-819	129	7	,	,	PUNCT
biomedich-819	129	8	and	and	CCONJ
biomedich-819	129	9	therapeutic	therapeutic	ADJ
biomedich-819	129	10	applications	application	NOUN
biomedich-819	129	11	.	.	PUNCT
biomedich-819	130	1	nature	nature	NOUN
biomedich-819	130	2	reviews	review	VERB
biomedich-819	130	3	molecular	molecular	ADJ
biomedich-819	130	4	cell	cell	NOUN
biomedich-819	130	5	biology	biology	NOUN
biomedich-819	130	6	.	.	PUNCT
biomedich-819	131	1	filhol	filhol	NOUN
biomedich-819	131	2	,	,	PUNCT
biomedich-819	131	3	o.	o.	PROPN
biomedich-819	131	4	,	,	PUNCT
biomedich-819	131	5	ciais	ciais	PROPN
biomedich-819	131	6	,	,	PUNCT
biomedich-819	131	7	d.	d.	PROPN
biomedich-819	131	8	,	,	PUNCT
biomedich-819	131	9	lajaunie	lajaunie	PROPN
biomedich-819	131	10	,	,	PUNCT
biomedich-819	131	11	c.	c.	NOUN
biomedich-819	131	12	,	,	PUNCT
biomedich-819	131	13	charbonnier	charbonnier	NOUN
biomedich-819	131	14	,	,	PUNCT
biomedich-819	131	15	p.	p.	NOUN
biomedich-819	131	16	,	,	PUNCT
biomedich-819	131	17	foveau	foveau	NOUN
biomedich-819	131	18	,	,	PUNCT
biomedich-819	131	19	n.	n.	NOUN
biomedich-819	131	20	,	,	PUNCT
biomedich-819	131	21	vert	vert	PROPN
biomedich-819	131	22	,	,	PUNCT
biomedich-819	131	23	j.	j.	PROPN
biomedich-819	131	24	p.	p.	PROPN
biomedich-819	131	25	,	,	PUNCT
biomedich-819	131	26	&	&	CCONJ
biomedich-819	131	27	vandenbrouck	vandenbrouck	PROPN
biomedich-819	131	28	,	,	PUNCT
biomedich-819	131	29	y.	y.	PROPN
biomedich-819	131	30	(	(	PUNCT
biomedich-819	131	31	2012	2012	NUM
biomedich-819	131	32	)	)	PUNCT
biomedich-819	131	33	.	.	PUNCT
biomedich-819	132	1	dsir	dsir	NOUN
biomedich-819	132	2	:	:	PUNCT
biomedich-819	132	3	assessing	assess	VERB
biomedich-819	132	4	the	the	DET
biomedich-819	132	5	design	design	NOUN
biomedich-819	132	6	of	of	ADP
biomedich-819	132	7	highly	highly	ADV
biomedich-819	132	8	potent	potent	ADJ
biomedich-819	132	9	sirna	sirna	PROPN
biomedich-819	132	10	by	by	ADP
biomedich-819	132	11	testing	test	VERB
biomedich-819	132	12	a	a	DET
biomedich-819	132	13	set	set	NOUN
biomedich-819	132	14	of	of	ADP
biomedich-819	132	15	cancerrelevant	cancerrelevant	NOUN
biomedich-819	132	16	target	target	NOUN
biomedich-819	132	17	genes	gene	NOUN
biomedich-819	132	18	.	.	PUNCT
biomedich-819	133	1	plos	plos	PROPN
biomedich-819	133	2	one	one	NUM
biomedich-819	133	3	,	,	PUNCT
biomedich-819	133	4	7(10	7(10	NUM
biomedich-819	133	5	)	)	PUNCT
biomedich-819	133	6	,	,	PUNCT
biomedich-819	133	7	1–11	1–11	PROPN
biomedich-819	133	8	.	.	PUNCT
biomedich-819	134	1	https://doi.org/10.1371/journal.pone.0048057	https://doi.org/10.1371/journal.pone.0048057	PROPN
biomedich-819	134	2	hartawan	hartawan	PROPN
biomedich-819	134	3	,	,	PUNCT
biomedich-819	134	4	r.	r.	PROPN
biomedich-819	134	5	,	,	PUNCT
biomedich-819	134	6	pujianto	pujianto	PROPN
biomedich-819	134	7	,	,	PUNCT
biomedich-819	134	8	d.	d.	PROPN
biomedich-819	134	9	a.	a.	PROPN
biomedich-819	134	10	,	,	PUNCT
biomedich-819	134	11	dharmayanti	dharmayanti	PROPN
biomedich-819	134	12	,	,	PUNCT
biomedich-819	134	13	n.	n.	PROPN
biomedich-819	134	14	l.	l.	PROPN
biomedich-819	134	15	p.	p.	PROPN
biomedich-819	134	16	i.	i.	PROPN
biomedich-819	134	17	,	,	PUNCT
biomedich-819	134	18	&	&	CCONJ
biomedich-819	134	19	soebandrio	soebandrio	PROPN
biomedich-819	134	20	,	,	PUNCT
biomedich-819	134	21	a.	a.	NOUN
biomedich-819	134	22	(	(	PUNCT
biomedich-819	134	23	2022	2022	NUM
biomedich-819	134	24	)	)	PUNCT
biomedich-819	134	25	.	.	PUNCT
biomedich-819	135	1	improving	improve	VERB
biomedich-819	135	2	sirna	sirna	PROPN
biomedich-819	135	3	design	design	NOUN
biomedich-819	135	4	targeting	target	VERB
biomedich-819	135	5	nucleoprotein	nucleoprotein	NOUN
biomedich-819	135	6	gene	gene	NOUN
biomedich-819	135	7	as	as	ADP
biomedich-819	135	8	antiviral	antiviral	ADJ
biomedich-819	135	9	against	against	ADP
biomedich-819	135	10	the	the	DET
biomedich-819	135	11	indonesian	indonesian	PROPN
biomedich-819	135	12	h5n1	h5n1	PROPN
biomedich-819	135	13	virus	virus	PROPN
biomedich-819	135	14	.	.	PUNCT
biomedich-819	136	1	journal	journal	PROPN
biomedich-819	136	2	of	of	ADP
biomedich-819	136	3	veterinary	veterinary	ADJ
biomedich-819	136	4	science	science	NOUN
biomedich-819	136	5	,	,	PUNCT
biomedich-819	136	6	23(2	23(2	NOUN
biomedich-819	136	7	)	)	PUNCT
biomedich-819	136	8	,	,	PUNCT
biomedich-819	136	9	36814718	36814718	NUM
biomedich-819	136	10	.	.	PUNCT
biomedich-819	137	1	https://doi.org/10.4142/jvs.21174	https://doi.org/10.4142/jvs.21174	PROPN
biomedich-819	137	2	kajino	kajino	PROPN
biomedich-819	137	3	,	,	PUNCT
biomedich-819	137	4	r.	r.	PROPN
biomedich-819	137	5	,	,	PUNCT
biomedich-819	137	6	sakamoto	sakamoto	PROPN
biomedich-819	137	7	,	,	PUNCT
biomedich-819	137	8	s.	s.	PROPN
biomedich-819	137	9	,	,	PUNCT
biomedich-819	137	10	&	&	CCONJ
biomedich-819	137	11	ueno	ueno	PROPN
biomedich-819	137	12	,	,	PUNCT
biomedich-819	137	13	y.	y.	PROPN
biomedich-819	137	14	(	(	PUNCT
biomedich-819	137	15	2022	2022	NUM
biomedich-819	137	16	)	)	PUNCT
biomedich-819	137	17	.	.	PUNCT
biomedich-819	138	1	synthesis	synthesis	NOUN
biomedich-819	138	2	,	,	PUNCT
biomedich-819	138	3	gene	gene	NOUN
biomedich-819	138	4	silencing	silence	VERB
biomedich-819	138	5	activity	activity	NOUN
biomedich-819	138	6	,	,	PUNCT
biomedich-819	138	7	thermal	thermal	ADJ
biomedich-819	138	8	stability	stability	NOUN
biomedich-819	138	9	,	,	PUNCT
biomedich-819	138	10	and	and	CCONJ
biomedich-819	138	11	serum	serum	VERB
biomedich-819	138	12	stability	stability	NOUN
biomedich-819	138	13	of	of	ADP
biomedich-819	138	14	sirna	sirna	PROPN
biomedich-819	138	15	containing	contain	VERB
biomedich-819	138	16	four	four	NUM
biomedich-819	138	17	(	(	PUNCT
biomedich-819	138	18	s)-5′-c	s)-5′-c	NOUN
biomedich-819	138	19	-	-	PUNCT
biomedich-819	138	20	aminopropyl-2′-omethylnucleosides	aminopropyl-2′-omethylnucleoside	NOUN
biomedich-819	138	21	(	(	PUNCT
biomedich-819	138	22	a	a	DET
biomedich-819	138	23	,	,	PUNCT
biomedich-819	138	24	adenosine	adenosine	NOUN
biomedich-819	138	25	;	;	PUNCT
biomedich-819	138	26	u	u	NOUN
biomedich-819	138	27	,	,	PUNCT
biomedich-819	138	28	uridine	uridine	NOUN
biomedich-819	138	29	;	;	PUNCT
biomedich-819	138	30	g	g	NOUN
biomedich-819	138	31	,	,	PUNCT
biomedich-819	138	32	guanosine	guanosine	NOUN
biomedich-819	138	33	;	;	PUNCT
biomedich-819	138	34	and	and	CCONJ
biomedich-819	138	35	c	c	X
biomedich-819	138	36	,	,	PUNCT
biomedich-819	138	37	cytidine	cytidine	NOUN
biomedich-819	138	38	)	)	PUNCT
biomedich-819	138	39	.	.	PUNCT
biomedich-819	139	1	rsc	rsc	PROPN
biomedich-819	139	2	advances	advance	NOUN
biomedich-819	139	3	,	,	PUNCT
biomedich-819	139	4	12(18	12(18	NUM
biomedich-819	139	5	)	)	PUNCT
biomedich-819	139	6	,	,	PUNCT
biomedich-819	139	7	11454–11476	11454–11476	NUM
biomedich-819	139	8	.	.	PUNCT
biomedich-819	140	1	https://doi.org/10.1039/d2ra00705c	https://doi.org/10.1039/d2ra00705c	PROPN
biomedich-819	140	2	liu	liu	PROPN
biomedich-819	140	3	,	,	PUNCT
biomedich-819	140	4	q.	q.	PROPN
biomedich-819	140	5	,	,	PUNCT
biomedich-819	140	6	zhou	zhou	PROPN
biomedich-819	140	7	,	,	PUNCT
biomedich-819	140	8	h.	h.	PROPN
biomedich-819	140	9	,	,	PUNCT
biomedich-819	140	10	cui	cui	PROPN
biomedich-819	140	11	,	,	PUNCT
biomedich-819	140	12	j.	j.	PROPN
biomedich-819	140	13	,	,	PUNCT
biomedich-819	140	14	cao	cao	PROPN
biomedich-819	140	15	,	,	PUNCT
biomedich-819	140	16	z.	z.	PROPN
biomedich-819	140	17	,	,	PUNCT
biomedich-819	140	18	&	&	CCONJ
biomedich-819	140	19	xu	xu	PROPN
biomedich-819	140	20	,	,	PUNCT
biomedich-819	140	21	y.	y.	PROPN
biomedich-819	140	22	(	(	PUNCT
biomedich-819	140	23	2012	2012	NUM
biomedich-819	140	24	)	)	PUNCT
biomedich-819	140	25	.	.	PUNCT
biomedich-819	141	1	reconsideration	reconsideration	NOUN
biomedich-819	141	2	of	of	ADP
biomedich-819	141	3	in	in	ADP
biomedich-819	141	4	-	-	PUNCT
biomedich-819	141	5	silico	silico	NOUN
biomedich-819	141	6	sirna	sirna	PROPN
biomedich-819	141	7	design	design	NOUN
biomedich-819	141	8	based	base	VERB
biomedich-819	141	9	on	on	ADP
biomedich-819	141	10	feature	feature	NOUN
biomedich-819	141	11	selection	selection	NOUN
biomedich-819	141	12	:	:	PUNCT
biomedich-819	141	13	a	a	DET
biomedich-819	141	14	cross	cross	ADJ
biomedich-819	141	15	-	-	ADJ
biomedich-819	141	16	platform	platform	ADJ
biomedich-819	141	17	data	datum	NOUN
biomedich-819	141	18	integration	integration	NOUN
biomedich-819	141	19	perspective	perspective	NOUN
biomedich-819	141	20	.	.	PUNCT
biomedich-819	142	1	plos	plos	PROPN
biomedich-819	142	2	one	one	NUM
biomedich-819	142	3	,	,	PUNCT
biomedich-819	142	4	7(5	7(5	NUM
biomedich-819	142	5	)	)	PUNCT
biomedich-819	142	6	,	,	PUNCT
biomedich-819	142	7	1–10	1–10	NOUN
biomedich-819	142	8	.	.	PUNCT
biomedich-819	143	1	https://doi.org/10.1371/journal.pone.0037879	https://doi.org/10.1371/journal.pone.0037879	PROPN
biomedich-819	143	2	lu	lu	PROPN
biomedich-819	143	3	,	,	PUNCT
biomedich-819	143	4	z.	z.	PROPN
biomedich-819	143	5	j.	j.	PROPN
biomedich-819	143	6	,	,	PUNCT
biomedich-819	143	7	gloor	gloor	PROPN
biomedich-819	143	8	,	,	PUNCT
biomedich-819	143	9	j.	j.	PROPN
biomedich-819	143	10	w.	w.	PROPN
biomedich-819	143	11	,	,	PUNCT
biomedich-819	143	12	&	&	CCONJ
biomedich-819	143	13	mathews	mathews	PROPN
biomedich-819	143	14	,	,	PUNCT
biomedich-819	143	15	d.	d.	PROPN
biomedich-819	143	16	h.	h.	PROPN
biomedich-819	143	17	(	(	PUNCT
biomedich-819	143	18	2009	2009	NUM
biomedich-819	143	19	)	)	PUNCT
biomedich-819	143	20	.	.	PUNCT
biomedich-819	144	1	improved	improve	VERB
biomedich-819	144	2	rna	rna	NOUN
biomedich-819	144	3	secondary	secondary	ADJ
biomedich-819	144	4	structure	structure	NOUN
biomedich-819	144	5	prediction	prediction	NOUN
biomedich-819	144	6	by	by	ADP
biomedich-819	144	7	maximizing	maximize	VERB
biomedich-819	144	8	expected	expect	VERB
biomedich-819	144	9	pair	pair	NOUN
biomedich-819	144	10	accuracy	accuracy	NOUN
biomedich-819	144	11	.	.	PUNCT
biomedich-819	145	1	rna	rna	NOUN
biomedich-819	145	2	,	,	PUNCT
biomedich-819	145	3	15(10	15(10	NUM
biomedich-819	145	4	)	)	PUNCT
biomedich-819	145	5	,	,	PUNCT
biomedich-819	145	6	1805–1813	1805–1813	NUM
biomedich-819	145	7	.	.	PUNCT
biomedich-819	146	1	https://doi.org/10.1261/rna.1643609	https://doi.org/10.1261/rna.1643609	PROPN
biomedich-819	146	2	lybarger	lybarger	NOUN
biomedich-819	146	3	,	,	PUNCT
biomedich-819	146	4	s.	s.	PROPN
biomedich-819	146	5	r.	r.	PROPN
biomedich-819	146	6	,	,	PUNCT
biomedich-819	146	7	&	&	CCONJ
biomedich-819	146	8	sandkvist	sandkvist	PROPN
biomedich-819	146	9	,	,	PUNCT
biomedich-819	146	10	m.	m.	NOUN
biomedich-819	146	11	(	(	PUNCT
biomedich-819	146	12	2004	2004	NUM
biomedich-819	146	13	)	)	PUNCT
biomedich-819	146	14	.	.	PUNCT
biomedich-819	147	1	a	a	DET
biomedich-819	147	2	hitchhiker	hitchhiker	NOUN
biomedich-819	147	3	’	'	PUNCT
biomedich-819	147	4	s	s	AUX
biomedich-819	147	5	guide	guide	NOUN
biomedich-819	147	6	to	to	ADP
biomedich-819	147	7	.	.	PUNCT
biomedich-819	148	1	science	science	NOUN
biomedich-819	148	2	,	,	PUNCT
biomedich-819	148	3	304(1	304(1	NUM
biomedich-819	148	4	)	)	PUNCT
biomedich-819	148	5	,	,	PUNCT
biomedich-819	148	6	1122–1123	1122–1123	NUM
biomedich-819	148	7	.	.	PUNCT
biomedich-819	149	1	murray	murray	PROPN
biomedich-819	149	2	,	,	PUNCT
biomedich-819	149	3	c.	c.	PROPN
biomedich-819	149	4	j.	j.	PROPN
biomedich-819	149	5	,	,	PUNCT
biomedich-819	149	6	ikuta	ikuta	PROPN
biomedich-819	149	7	,	,	PUNCT
biomedich-819	149	8	k.	k.	PROPN
biomedich-819	149	9	s.	s.	PROPN
biomedich-819	149	10	,	,	PUNCT
biomedich-819	149	11	sharara	sharara	NOUN
biomedich-819	149	12	,	,	PUNCT
biomedich-819	149	13	f.	f.	PROPN
biomedich-819	149	14	,	,	PUNCT
biomedich-819	149	15	swetschinski	swetschinski	PROPN
biomedich-819	149	16	,	,	PUNCT
biomedich-819	149	17	l.	l.	PROPN
biomedich-819	149	18	,	,	PUNCT
biomedich-819	149	19	robles	robles	PROPN
biomedich-819	149	20	aguilar	aguilar	PROPN
biomedich-819	149	21	,	,	PUNCT
biomedich-819	149	22	g.	g.	PROPN
biomedich-819	149	23	,	,	PUNCT
biomedich-819	149	24	gray	gray	ADJ
biomedich-819	149	25	,	,	PUNCT
biomedich-819	149	26	a.	a.	NOUN
biomedich-819	149	27	,	,	PUNCT
biomedich-819	149	28	han	han	PROPN
biomedich-819	149	29	,	,	PUNCT
biomedich-819	149	30	c.	c.	PROPN
biomedich-819	149	31	,	,	PUNCT
biomedich-819	149	32	bisignano	bisignano	NOUN
biomedich-819	149	33	,	,	PUNCT
biomedich-819	149	34	c.	c.	PROPN
biomedich-819	149	35	,	,	PUNCT
biomedich-819	149	36	rao	rao	PROPN
biomedich-819	149	37	,	,	PUNCT
biomedich-819	149	38	p.	p.	NOUN
biomedich-819	149	39	,	,	PUNCT
biomedich-819	149	40	wool	wool	PROPN
biomedich-819	149	41	,	,	PUNCT
biomedich-819	149	42	e.	e.	PROPN
biomedich-819	149	43	,	,	PUNCT
biomedich-819	149	44	johnson	johnson	PROPN
biomedich-819	149	45	,	,	PUNCT
biomedich-819	149	46	s.	s.	PROPN
biomedich-819	149	47	c.	c.	PROPN
biomedich-819	149	48	,	,	PUNCT
biomedich-819	149	49	browne	browne	PROPN
biomedich-819	149	50	,	,	PUNCT
biomedich-819	149	51	a.	a.	PROPN
biomedich-819	149	52	j.	j.	PROPN
biomedich-819	149	53	,	,	PUNCT
biomedich-819	149	54	chipeta	chipeta	PROPN
biomedich-819	149	55	,	,	PUNCT
biomedich-819	149	56	m.	m.	NOUN
biomedich-819	149	57	g.	g.	PROPN
biomedich-819	149	58	,	,	PUNCT
biomedich-819	149	59	fell	fall	VERB
biomedich-819	149	60	,	,	PUNCT
biomedich-819	149	61	f.	f.	PROPN
biomedich-819	149	62	,	,	PUNCT
biomedich-819	149	63	hackett	hackett	PROPN
biomedich-819	149	64	,	,	PUNCT
biomedich-819	149	65	s.	s.	PROPN
biomedich-819	149	66	,	,	PUNCT
biomedich-819	149	67	haines	haine	NOUN
biomedich-819	149	68	-	-	PUNCT
biomedich-819	149	69	woodhouse	woodhouse	PROPN
biomedich-819	149	70	,	,	PUNCT
biomedich-819	149	71	g.	g.	PROPN
biomedich-819	149	72	,	,	PUNCT
biomedich-819	149	73	kashef	kashef	PROPN
biomedich-819	149	74	hamadani	hamadani	PROPN
biomedich-819	149	75	,	,	PUNCT
biomedich-819	149	76	b.	b.	PROPN
biomedich-819	149	77	h.	h.	PROPN
biomedich-819	149	78	,	,	PUNCT
biomedich-819	149	79	kumaran	kumaran	PROPN
biomedich-819	149	80	,	,	PUNCT
biomedich-819	149	81	e.	e.	PROPN
biomedich-819	149	82	a.	a.	PROPN
biomedich-819	149	83	p.	p.	PROPN
biomedich-819	149	84	,	,	PUNCT
biomedich-819	149	85	mcmanigal	mcmanigal	PROPN
biomedich-819	149	86	,	,	PUNCT
biomedich-819	149	87	b.	b.	PROPN
biomedich-819	149	88	,	,	PUNCT
biomedich-819	149	89	…	…	PUNCT
biomedich-819	149	90	naghavi	naghavi	ADJ
biomedich-819	149	91	,	,	PUNCT
biomedich-819	149	92	m.	m.	NOUN
biomedich-819	149	93	(	(	PUNCT
biomedich-819	149	94	2022	2022	NUM
biomedich-819	149	95	)	)	PUNCT
biomedich-819	149	96	.	.	PUNCT
biomedich-819	150	1	global	global	ADJ
biomedich-819	150	2	burden	burden	NOUN
biomedich-819	150	3	of	of	ADP
biomedich-819	150	4	bacterial	bacterial	ADJ
biomedich-819	150	5	antimicrobial	antimicrobial	ADJ
biomedich-819	150	6	resistance	resistance	NOUN
biomedich-819	150	7	in	in	ADP
biomedich-819	150	8	2019	2019	NUM
biomedich-819	150	9	:	:	PUNCT
biomedich-819	150	10	a	a	DET
biomedich-819	150	11	926	926	NUM
biomedich-819	150	12	biology	biology	NOUN
biomedich-819	150	13	,	,	PUNCT
biomedich-819	150	14	medicine	medicine	NOUN
biomedich-819	150	15	,	,	PUNCT
biomedich-819	150	16	&	&	CCONJ
biomedich-819	150	17	natural	natural	ADJ
biomedich-819	150	18	product	product	NOUN
biomedich-819	150	19	chemistry	chemistry	NOUN
biomedich-819	150	20	14	14	NUM
biomedich-819	150	21	(	(	PUNCT
biomedich-819	150	22	2	2	NUM
biomedich-819	150	23	)	)	PUNCT
biomedich-819	150	24	,	,	PUNCT
biomedich-819	150	25	2025	2025	NUM
biomedich-819	150	26	:	:	PUNCT
biomedich-819	150	27	921	921	NUM
biomedich-819	150	28	-	-	SYM
biomedich-819	150	29	926	926	NUM
biomedich-819	150	30	systematic	systematic	ADJ
biomedich-819	150	31	analysis	analysis	NOUN
biomedich-819	150	32	.	.	PUNCT
biomedich-819	151	1	the	the	DET
biomedich-819	151	2	lancet	lancet	NOUN
biomedich-819	151	3	,	,	PUNCT
biomedich-819	151	4	399(10325	399(10325	NUM
biomedich-819	151	5	)	)	PUNCT
biomedich-819	151	6	,	,	PUNCT
biomedich-819	151	7	629–655	629–655	NUM
biomedich-819	151	8	.	.	PUNCT
biomedich-819	152	1	https://doi.org/10.1016/s0140-6736(21)02724-0	https://doi.org/10.1016/s0140-6736(21)02724-0	PROPN
biomedich-819	152	2	mysara	mysara	PROPN
biomedich-819	152	3	m	m	PROPN
biomedich-819	152	4	,	,	PUNCT
biomedich-819	152	5	garibaldi	garibaldi	PROPN
biomedich-819	152	6	jm	jm	PROPN
biomedich-819	152	7	,	,	PUNCT
biomedich-819	152	8	e.	e.	PROPN
biomedich-819	152	9	m.	m.	PROPN
biomedich-819	152	10	(	(	PUNCT
biomedich-819	152	11	2011	2011	NUM
biomedich-819	152	12	)	)	PUNCT
biomedich-819	152	13	.	.	PUNCT
biomedich-819	153	1	mysirna	mysirna	NOUN
biomedich-819	153	2	-	-	PUNCT
biomedich-819	153	3	designer	designer	NOUN
biomedich-819	153	4	:	:	PUNCT
biomedich-819	153	5	a	a	DET
biomedich-819	153	6	workflow	workflow	NOUN
biomedich-819	153	7	for	for	ADP
biomedich-819	153	8	efficient	efficient	ADJ
biomedich-819	153	9	sirna	sirna	PROPN
biomedich-819	153	10	design	design	PROPN
biomedich-819	153	11	.	.	PUNCT
biomedich-819	154	1	plos	plos	PROPN
biomedich-819	154	2	one	one	NUM
biomedich-819	154	3	,	,	PUNCT
biomedich-819	154	4	6(10	6(10	NUM
biomedich-819	154	5	)	)	PUNCT
biomedich-819	154	6	.	.	PUNCT
biomedich-819	155	1	pan	pan	PROPN
biomedich-819	155	2	,	,	PUNCT
biomedich-819	155	3	w.	w.	PROPN
biomedich-819	155	4	j.	j.	PROPN
biomedich-819	155	5	,	,	PUNCT
biomedich-819	155	6	chen	chen	PROPN
biomedich-819	155	7	,	,	PUNCT
biomedich-819	155	8	c.	c.	PROPN
biomedich-819	155	9	w.	w.	PROPN
biomedich-819	155	10	,	,	PUNCT
biomedich-819	155	11	&	&	CCONJ
biomedich-819	155	12	chu	chu	PROPN
biomedich-819	155	13	,	,	PUNCT
biomedich-819	155	14	y.	y.	PROPN
biomedich-819	155	15	w.	w.	PROPN
biomedich-819	155	16	(	(	PUNCT
biomedich-819	155	17	2011	2011	NUM
biomedich-819	155	18	)	)	PUNCT
biomedich-819	155	19	.	.	PUNCT
biomedich-819	156	1	sipred	sipre	VERB
biomedich-819	156	2	:	:	PUNCT
biomedich-819	156	3	predicting	predict	VERB
biomedich-819	156	4	sirna	sirna	PROPN
biomedich-819	156	5	efficacy	efficacy	NOUN
biomedich-819	156	6	using	use	VERB
biomedich-819	156	7	various	various	ADJ
biomedich-819	156	8	characteristic	characteristic	ADJ
biomedich-819	156	9	methods	method	NOUN
biomedich-819	156	10	.	.	PUNCT
biomedich-819	157	1	plos	plos	PROPN
biomedich-819	157	2	one	one	NUM
biomedich-819	157	3	,	,	PUNCT
biomedich-819	157	4	6(11	6(11	NUM
biomedich-819	157	5	)	)	PUNCT
biomedich-819	157	6	,	,	PUNCT
biomedich-819	157	7	1–7	1–7	X
biomedich-819	157	8	.	.	PUNCT
biomedich-819	158	1	https://doi.org/10.1371/journal.pone.0027602	https://doi.org/10.1371/journal.pone.0027602	PROPN
biomedich-819	158	2	peng	peng	PROPN
biomedich-819	158	3	,	,	PUNCT
biomedich-819	158	4	q.	q.	PROPN
biomedich-819	158	5	,	,	PUNCT
biomedich-819	158	6	tang	tang	PROPN
biomedich-819	158	7	,	,	PUNCT
biomedich-819	158	8	x.	x.	PROPN
biomedich-819	158	9	,	,	PUNCT
biomedich-819	158	10	dong	dong	PROPN
biomedich-819	158	11	,	,	PUNCT
biomedich-819	158	12	w.	w.	PROPN
biomedich-819	158	13	,	,	PUNCT
biomedich-819	158	14	sun	sun	PROPN
biomedich-819	158	15	,	,	PUNCT
biomedich-819	158	16	n.	n.	NOUN
biomedich-819	158	17	,	,	PUNCT
biomedich-819	158	18	&	&	CCONJ
biomedich-819	158	19	yuan	yuan	PROPN
biomedich-819	158	20	,	,	PUNCT
biomedich-819	158	21	w.	w.	PROPN
biomedich-819	158	22	(	(	PUNCT
biomedich-819	158	23	2023	2023	NUM
biomedich-819	158	24	)	)	PUNCT
biomedich-819	158	25	.	.	PUNCT
biomedich-819	159	1	a	a	DET
biomedich-819	159	2	review	review	NOUN
biomedich-819	159	3	of	of	ADP
biomedich-819	159	4	biofilm	biofilm	NOUN
biomedich-819	159	5	formation	formation	NOUN
biomedich-819	159	6	of	of	ADP
biomedich-819	159	7	staphylococcus	staphylococcus	NOUN
biomedich-819	159	8	aureus	aureus	NOUN
biomedich-819	159	9	and	and	CCONJ
biomedich-819	159	10	its	its	PRON
biomedich-819	159	11	regulation	regulation	NOUN
biomedich-819	159	12	mechanism	mechanism	NOUN
biomedich-819	159	13	.	.	PUNCT
biomedich-819	160	1	antibiotics	antibiotic	NOUN
biomedich-819	160	2	,	,	PUNCT
biomedich-819	160	3	12(1	12(1	NUM
biomedich-819	160	4	)	)	PUNCT
biomedich-819	160	5	,	,	PUNCT
biomedich-819	160	6	1–21	1–21	PROPN
biomedich-819	160	7	.	.	PUNCT
biomedich-819	161	1	https://doi.org/10.3390/antibiotics12010012	https://doi.org/10.3390/antibiotics12010012	PROPN
biomedich-819	161	2	perez	perez	PROPN
biomedich-819	161	3	-	-	PUNCT
biomedich-819	161	4	mendez	mendez	PROPN
biomedich-819	161	5	,	,	PUNCT
biomedich-819	161	6	m.	m.	NOUN
biomedich-819	161	7	,	,	PUNCT
biomedich-819	161	8	zárate	zárate	NOUN
biomedich-819	161	9	-	-	PUNCT
biomedich-819	161	10	segura	segura	ADJ
biomedich-819	161	11	,	,	PUNCT
biomedich-819	161	12	p.	p.	PROPN
biomedich-819	161	13	,	,	PUNCT
biomedich-819	161	14	salas	salas	PROPN
biomedich-819	161	15	-	-	PUNCT
biomedich-819	161	16	benito	benito	PROPN
biomedich-819	161	17	,	,	PUNCT
biomedich-819	161	18	j.	j.	PROPN
biomedich-819	161	19	,	,	PUNCT
biomedich-819	161	20	&	&	CCONJ
biomedich-819	161	21	bastidagonzález	bastidagonzález	PROPN
biomedich-819	161	22	,	,	PUNCT
biomedich-819	161	23	f.	f.	PROPN
biomedich-819	161	24	(	(	PUNCT
biomedich-819	161	25	2020	2020	NUM
biomedich-819	161	26	)	)	PUNCT
biomedich-819	161	27	.	.	PUNCT
biomedich-819	162	1	sirna	sirna	PROPN
biomedich-819	162	2	design	design	VERB
biomedich-819	162	3	to	to	PART
biomedich-819	162	4	silence	silence	VERB
biomedich-819	162	5	the	the	DET
biomedich-819	162	6	3	3	NUM
biomedich-819	162	7	′	′	NUM
biomedich-819	162	8	utr	utr	NOUN
biomedich-819	162	9	region	region	NOUN
biomedich-819	162	10	of	of	ADP
biomedich-819	162	11	zika	zika	X
biomedich-819	162	12	virus	virus	NOUN
biomedich-819	162	13	.	.	PUNCT
biomedich-819	163	1	biomed	biome	VERB
biomedich-819	163	2	research	research	NOUN
biomedich-819	163	3	international	international	PROPN
biomedich-819	163	4	,	,	PUNCT
biomedich-819	163	5	2020	2020	NUM
biomedich-819	163	6	.	.	PUNCT
biomedich-819	164	1	https://doi.org/10.1155/2020/6759346	https://doi.org/10.1155/2020/6759346	PROPN
biomedich-819	164	2	tran	tran	PROPN
biomedich-819	164	3	,	,	PUNCT
biomedich-819	164	4	n.	n.	PROPN
biomedich-819	164	5	n.	n.	PROPN
biomedich-819	164	6	,	,	PUNCT
biomedich-819	164	7	morrisette	morrisette	NOUN
biomedich-819	164	8	,	,	PUNCT
biomedich-819	164	9	t.	t.	PROPN
biomedich-819	164	10	,	,	PUNCT
biomedich-819	164	11	jorgensen	jorgensen	PROPN
biomedich-819	164	12	,	,	PUNCT
biomedich-819	164	13	s.	s.	PROPN
biomedich-819	164	14	c.	c.	PROPN
biomedich-819	164	15	j.	j.	PROPN
biomedich-819	164	16	,	,	PUNCT
biomedich-819	164	17	orench	orench	NOUN
biomedich-819	164	18	-	-	PUNCT
biomedich-819	164	19	benvenutti	benvenutti	NOUN
biomedich-819	164	20	,	,	PUNCT
biomedich-819	164	21	j.	j.	PROPN
biomedich-819	164	22	m.	m.	PROPN
biomedich-819	164	23	,	,	PUNCT
biomedich-819	164	24	&	&	CCONJ
biomedich-819	164	25	kebriaei	kebriaei	PROPN
biomedich-819	164	26	,	,	PUNCT
biomedich-819	164	27	r.	r.	PROPN
biomedich-819	164	28	(	(	PUNCT
biomedich-819	164	29	2023	2023	NUM
biomedich-819	164	30	)	)	PUNCT
biomedich-819	164	31	.	.	PUNCT
biomedich-819	165	1	current	current	ADJ
biomedich-819	165	2	therapies	therapy	NOUN
biomedich-819	165	3	and	and	CCONJ
biomedich-819	165	4	challenges	challenge	NOUN
biomedich-819	165	5	for	for	ADP
biomedich-819	165	6	the	the	DET
biomedich-819	165	7	treatment	treatment	NOUN
biomedich-819	165	8	of	of	ADP
biomedich-819	165	9	staphylococcus	staphylococcus	NOUN
biomedich-819	165	10	aureus	aureus	NOUN
biomedich-819	165	11	biofilm	biofilm	NOUN
biomedich-819	165	12	-	-	PUNCT
biomedich-819	165	13	related	relate	VERB
biomedich-819	165	14	infections	infection	NOUN
biomedich-819	165	15	.	.	PUNCT
biomedich-819	166	1	pharmacotherapy	pharmacotherapy	NOUN
biomedich-819	166	2	,	,	PUNCT
biomedich-819	166	3	43(8	43(8	NUM
biomedich-819	166	4	)	)	PUNCT
biomedich-819	166	5	,	,	PUNCT
biomedich-819	166	6	816–832	816–832	NUM
biomedich-819	166	7	.	.	PUNCT
biomedich-819	166	8	https://doi.org/10.1002/phar.2806	https://doi.org/10.1002/phar.2806	NOUN