id	sid	tid	token	lemma	pos
biomedich-872	1	1	biology	biology	NOUN
biomedich-872	1	2	,	,	PUNCT
biomedich-872	1	3	medicine	medicine	NOUN
biomedich-872	1	4	,	,	PUNCT
biomedich-872	1	5	&	&	CCONJ
biomedich-872	1	6	natural	natural	ADJ
biomedich-872	1	7	product	product	NOUN
biomedich-872	1	8	chemistry	chemistry	NOUN
biomedich-872	1	9	issn	issn	VERB
biomedich-872	1	10	2089	2089	NUM
biomedich-872	1	11	-	-	SYM
biomedich-872	1	12	6514	6514	NUM
biomedich-872	1	13	(	(	PUNCT
biomedich-872	1	14	paper	paper	NOUN
biomedich-872	1	15	)	)	PUNCT
biomedich-872	1	16	volume	volume	NOUN
biomedich-872	1	17	14	14	NUM
biomedich-872	1	18	,	,	PUNCT
biomedich-872	1	19	number	number	NOUN
biomedich-872	1	20	2	2	NUM
biomedich-872	1	21	,	,	PUNCT
biomedich-872	1	22	october	october	PROPN
biomedich-872	1	23	2025	2025	NUM
biomedich-872	1	24	|	|	ADV
biomedich-872	1	25	pages	page	NOUN
biomedich-872	1	26	:	:	PUNCT
biomedich-872	1	27	817	817	NUM
biomedich-872	1	28	-	-	SYM
biomedich-872	1	29	824	824	NUM
biomedich-872	1	30	|	|	ADV
biomedich-872	1	31	doi	doi	NOUN
biomedich-872	1	32	:	:	PUNCT
biomedich-872	1	33	10.14421	10.14421	NUM
biomedich-872	1	34	/	/	SYM
biomedich-872	1	35	biomedich.2025.142.817	biomedich.2025.142.817	NOUN
biomedich-872	1	36	-	-	PUNCT
biomedich-872	1	37	824	824	NUM
biomedich-872	1	38	issn	issn	NOUN
biomedich-872	1	39	2540	2540	NUM
biomedich-872	1	40	-	-	SYM
biomedich-872	1	41	9328	9328	NUM
biomedich-872	1	42	(	(	PUNCT
biomedich-872	1	43	online	online	ADV
biomedich-872	1	44	)	)	PUNCT
biomedich-872	1	45	predicting	predict	VERB
biomedich-872	1	46	the	the	DET
biomedich-872	1	47	anti	anti	ADJ
biomedich-872	1	48	-	-	ADJ
biomedich-872	1	49	pulmonary	pulmonary	ADJ
biomedich-872	1	50	fibrosis	fibrosis	NOUN
biomedich-872	1	51	potential	potential	NOUN
biomedich-872	1	52	of	of	ADP
biomedich-872	1	53	physalis	physalis	NOUN
biomedich-872	1	54	angulata	angulata	ADJ
biomedich-872	1	55	compounds	compound	VERB
biomedich-872	1	56	a	a	DET
biomedich-872	1	57	computational	computational	ADJ
biomedich-872	1	58	study	study	NOUN
biomedich-872	1	59	muhammad	muhammad	PROPN
biomedich-872	1	60	farid	farid	PROPN
biomedich-872	1	61	*	*	PROPN
biomedich-872	1	62	,	,	PUNCT
biomedich-872	1	63	assa	assa	PROPN
biomedich-872	1	64	aulia	aulia	PROPN
biomedich-872	1	65	kirana	kirana	PROPN
biomedich-872	1	66	,	,	PUNCT
biomedich-872	1	67	nandita	nandita	PROPN
biomedich-872	1	68	diah	diah	PROPN
biomedich-872	1	69	oktaviana	oktaviana	PROPN
biomedich-872	1	70	,	,	PUNCT
biomedich-872	1	71	sofia	sofia	PROPN
biomedich-872	1	72	rasyda	rasyda	PROPN
biomedich-872	1	73	,	,	PUNCT
biomedich-872	1	74	dwi	dwi	PROPN
biomedich-872	1	75	anggraini	anggraini	PROPN
biomedich-872	1	76	,	,	PUNCT
biomedich-872	1	77	widya	widya	PROPN
biomedich-872	1	78	aryana	aryana	PROPN
biomedich-872	1	79	ramadhania	ramadhania	PROPN
biomedich-872	1	80	department	department	PROPN
biomedich-872	1	81	of	of	ADP
biomedich-872	1	82	medicine	medicine	NOUN
biomedich-872	1	83	,	,	PUNCT
biomedich-872	1	84	faculty	faculty	NOUN
biomedich-872	1	85	of	of	ADP
biomedich-872	1	86	medicine	medicine	NOUN
biomedich-872	1	87	,	,	PUNCT
biomedich-872	1	88	ahmad	ahmad	PROPN
biomedich-872	1	89	dahlan	dahlan	PROPN
biomedich-872	1	90	university	university	PROPN
biomedich-872	1	91	,	,	PUNCT
biomedich-872	1	92	yogyakarta	yogyakarta	PROPN
biomedich-872	1	93	,	,	PUNCT
biomedich-872	1	94	indonesia	indonesia	PROPN
biomedich-872	1	95	jl	jl	PROPN
biomedich-872	1	96	.	.	PUNCT
biomedich-872	1	97	universitas	universitas	PROPN
biomedich-872	1	98	ahmad	ahmad	PROPN
biomedich-872	1	99	dahlan	dahlan	PROPN
biomedich-872	1	100	kampus	kampus	PROPN
biomedich-872	1	101	4	4	NUM
biomedich-872	1	102	,	,	PUNCT
biomedich-872	1	103	kragilan	kragilan	ADJ
biomedich-872	1	104	,	,	PUNCT
biomedich-872	1	105	tamanan	tamanan	ADJ
biomedich-872	1	106	,	,	PUNCT
biomedich-872	2	1	kec	kec	PROPN
biomedich-872	2	2	.	.	PUNCT
biomedich-872	2	3	banguntapan	banguntapan	PROPN
biomedich-872	2	4	,	,	PUNCT
biomedich-872	2	5	kabupaten	kabupaten	PROPN
biomedich-872	2	6	bantul	bantul	PROPN
biomedich-872	2	7	,	,	PUNCT
biomedich-872	2	8	daerah	daerah	PROPN
biomedich-872	2	9	istimewa	istimewa	PROPN
biomedich-872	2	10	yogyakarta	yogyakarta	PROPN
biomedich-872	2	11	55191	55191	NUM
biomedich-872	2	12	,	,	PUNCT
biomedich-872	2	13	indonesia	indonesia	PROPN
biomedich-872	2	14	.	.	PUNCT
biomedich-872	3	1	corresponding	correspond	VERB
biomedich-872	3	2	author	author	NOUN
biomedich-872	3	3	*	*	PROPN
biomedich-872	3	4	muhammad2100034023@webmail.uad.ac.id	muhammad2100034023@webmail.uad.ac.id	NOUN
biomedich-872	3	5	abstract	abstract	ADJ
biomedich-872	3	6	pulmonary	pulmonary	ADJ
biomedich-872	3	7	fibrosis	fibrosis	NOUN
biomedich-872	3	8	is	be	AUX
biomedich-872	3	9	a	a	DET
biomedich-872	3	10	progressive	progressive	ADJ
biomedich-872	3	11	lung	lung	NOUN
biomedich-872	3	12	disease	disease	NOUN
biomedich-872	3	13	characterized	characterize	VERB
biomedich-872	3	14	by	by	ADP
biomedich-872	3	15	tissue	tissue	NOUN
biomedich-872	3	16	scarring	scarring	NOUN
biomedich-872	3	17	and	and	CCONJ
biomedich-872	3	18	respiratory	respiratory	ADJ
biomedich-872	3	19	decline	decline	NOUN
biomedich-872	3	20	.	.	PUNCT
biomedich-872	4	1	existing	exist	VERB
biomedich-872	4	2	treatments	treatment	NOUN
biomedich-872	4	3	have	have	VERB
biomedich-872	4	4	limited	limit	VERB
biomedich-872	4	5	efficacy	efficacy	NOUN
biomedich-872	4	6	and	and	CCONJ
biomedich-872	4	7	significant	significant	ADJ
biomedich-872	4	8	side	side	NOUN
biomedich-872	4	9	effects	effect	NOUN
biomedich-872	4	10	.	.	PUNCT
biomedich-872	5	1	physalis	physali	NOUN
biomedich-872	5	2	angulata	angulata	VERB
biomedich-872	5	3	,	,	PUNCT
biomedich-872	5	4	a	a	DET
biomedich-872	5	5	traditional	traditional	ADJ
biomedich-872	5	6	medicinal	medicinal	ADJ
biomedich-872	5	7	plant	plant	NOUN
biomedich-872	5	8	,	,	PUNCT
biomedich-872	5	9	shows	show	VERB
biomedich-872	5	10	promise	promise	NOUN
biomedich-872	5	11	for	for	ADP
biomedich-872	5	12	antifibrotic	antifibrotic	ADJ
biomedich-872	5	13	therapy	therapy	NOUN
biomedich-872	5	14	due	due	ADP
biomedich-872	5	15	to	to	ADP
biomedich-872	5	16	its	its	PRON
biomedich-872	5	17	bioactive	bioactive	NOUN
biomedich-872	5	18	compounds	compound	NOUN
biomedich-872	5	19	potentially	potentially	ADV
biomedich-872	5	20	targeting	target	VERB
biomedich-872	5	21	key	key	ADJ
biomedich-872	5	22	fibrotic	fibrotic	ADJ
biomedich-872	5	23	pathways	pathway	NOUN
biomedich-872	5	24	.	.	PUNCT
biomedich-872	6	1	this	this	DET
biomedich-872	6	2	study	study	NOUN
biomedich-872	6	3	aims	aim	VERB
biomedich-872	6	4	to	to	PART
biomedich-872	6	5	predict	predict	VERB
biomedich-872	6	6	the	the	DET
biomedich-872	6	7	potential	potential	NOUN
biomedich-872	6	8	of	of	ADP
biomedich-872	6	9	physalis	physali	NOUN
biomedich-872	6	10	angulata	angulata	ADJ
biomedich-872	6	11	compounds	compound	NOUN
biomedich-872	6	12	to	to	ADP
biomedich-872	6	13	pi3k	pi3k	PROPN
biomedich-872	6	14	/	/	SYM
biomedich-872	6	15	akt	akt	PROPN
biomedich-872	6	16	protein	protein	NOUN
biomedich-872	6	17	as	as	ADP
biomedich-872	6	18	candidates	candidate	NOUN
biomedich-872	6	19	for	for	ADP
biomedich-872	6	20	antifibrotic	antifibrotic	ADJ
biomedich-872	6	21	therapy	therapy	NOUN
biomedich-872	6	22	.	.	PUNCT
biomedich-872	7	1	ten	ten	NUM
biomedich-872	7	2	active	active	ADJ
biomedich-872	7	3	compounds	compound	NOUN
biomedich-872	7	4	from	from	ADP
biomedich-872	7	5	p.	p.	NOUN
biomedich-872	7	6	angulata	angulata	NOUN
biomedich-872	7	7	were	be	AUX
biomedich-872	7	8	docked	dock	VERB
biomedich-872	7	9	against	against	ADP
biomedich-872	7	10	the	the	DET
biomedich-872	7	11	pi3k	pi3k	PROPN
biomedich-872	7	12	/	/	SYM
biomedich-872	7	13	akt	akt	PROPN
biomedich-872	7	14	protein	protein	NOUN
biomedich-872	7	15	(	(	PUNCT
biomedich-872	7	16	pdb	pdb	PROPN
biomedich-872	7	17	i	i	NOUN
biomedich-872	7	18	d	d	PROPN
biomedich-872	7	19	:	:	PUNCT
biomedich-872	7	20	2uzt	2uzt	NUM
biomedich-872	7	21	)	)	PUNCT
biomedich-872	7	22	using	use	VERB
biomedich-872	7	23	autodock	autodock	PROPN
biomedich-872	7	24	vina	vina	PROPN
biomedich-872	7	25	.	.	PUNCT
biomedich-872	8	1	docking	docking	NOUN
biomedich-872	8	2	was	be	AUX
biomedich-872	8	3	validated	validate	VERB
biomedich-872	8	4	by	by	ADP
biomedich-872	8	5	redocking	redocke	VERB
biomedich-872	8	6	the	the	DET
biomedich-872	8	7	native	native	ADJ
biomedich-872	8	8	ligand	ligand	NOUN
biomedich-872	8	9	.	.	PUNCT
biomedich-872	9	1	binding	bind	VERB
biomedich-872	9	2	affinities	affinity	NOUN
biomedich-872	9	3	and	and	CCONJ
biomedich-872	9	4	molecular	molecular	ADJ
biomedich-872	9	5	interactions	interaction	NOUN
biomedich-872	9	6	were	be	AUX
biomedich-872	9	7	analyzed	analyze	VERB
biomedich-872	9	8	.	.	PUNCT
biomedich-872	10	1	admet	admet	PROPN
biomedich-872	10	2	properties	property	NOUN
biomedich-872	10	3	were	be	AUX
biomedich-872	10	4	predicted	predict	VERB
biomedich-872	10	5	via	via	ADP
biomedich-872	10	6	the	the	DET
biomedich-872	10	7	pkcsm	pkcsm	NOUN
biomedich-872	10	8	platform	platform	NOUN
biomedich-872	10	9	to	to	PART
biomedich-872	10	10	assess	assess	VERB
biomedich-872	10	11	pharmacokinetics	pharmacokinetic	NOUN
biomedich-872	10	12	and	and	CCONJ
biomedich-872	10	13	toxicity	toxicity	NOUN
biomedich-872	10	14	.	.	PUNCT
biomedich-872	11	1	myricetrin	myricetrin	NOUN
biomedich-872	11	2	exhibited	exhibit	VERB
biomedich-872	11	3	the	the	DET
biomedich-872	11	4	strongest	strong	ADJ
biomedich-872	11	5	binding	bind	VERB
biomedich-872	11	6	affinity	affinity	NOUN
biomedich-872	11	7	(	(	PUNCT
biomedich-872	11	8	-9.6	-9.6	ADP
biomedich-872	11	9	kcal	kcal	NOUN
biomedich-872	11	10	/	/	SYM
biomedich-872	11	11	mol	mol	NOUN
biomedich-872	11	12	)	)	PUNCT
biomedich-872	11	13	,	,	PUNCT
biomedich-872	11	14	surpassing	surpass	VERB
biomedich-872	11	15	the	the	DET
biomedich-872	11	16	native	native	ADJ
biomedich-872	11	17	ligand	ligand	NOUN
biomedich-872	11	18	(	(	PUNCT
biomedich-872	11	19	-9.1	-9.1	PROPN
biomedich-872	11	20	kcal	kcal	PROPN
biomedich-872	11	21	/	/	SYM
biomedich-872	11	22	mol	mol	PROPN
biomedich-872	11	23	)	)	PUNCT
biomedich-872	11	24	.	.	PUNCT
biomedich-872	12	1	other	other	ADJ
biomedich-872	12	2	flavonoids	flavonoid	NOUN
biomedich-872	12	3	,	,	PUNCT
biomedich-872	12	4	including	include	VERB
biomedich-872	12	5	eriodictyol	eriodictyol	NOUN
biomedich-872	12	6	(	(	PUNCT
biomedich-872	12	7	-8.9	-8.9	INTJ
biomedich-872	12	8	kcal	kcal	PROPN
biomedich-872	12	9	/	/	SYM
biomedich-872	12	10	mol	mol	NOUN
biomedich-872	12	11	)	)	PUNCT
biomedich-872	12	12	,	,	PUNCT
biomedich-872	12	13	naringin	naringin	PROPN
biomedich-872	12	14	(	(	PUNCT
biomedich-872	12	15	-8.8	-8.8	PROPN
biomedich-872	12	16	kcal	kcal	PROPN
biomedich-872	12	17	/	/	SYM
biomedich-872	12	18	mol	mol	NOUN
biomedich-872	12	19	)	)	PUNCT
biomedich-872	12	20	,	,	PUNCT
biomedich-872	12	21	and	and	CCONJ
biomedich-872	12	22	apigenin	apigenin	INTJ
biomedich-872	12	23	(	(	PUNCT
biomedich-872	12	24	-8.5	-8.5	INTJ
biomedich-872	12	25	kcal	kcal	PROPN
biomedich-872	12	26	/	/	SYM
biomedich-872	12	27	mol	mol	NOUN
biomedich-872	12	28	)	)	PUNCT
biomedich-872	12	29	,	,	PUNCT
biomedich-872	12	30	also	also	ADV
biomedich-872	12	31	showed	show	VERB
biomedich-872	12	32	favorable	favorable	ADJ
biomedich-872	12	33	affinities	affinity	NOUN
biomedich-872	12	34	.	.	PUNCT
biomedich-872	13	1	critical	critical	ADJ
biomedich-872	13	2	amino	amino	NOUN
biomedich-872	13	3	acids	acid	NOUN
biomedich-872	13	4	involved	involve	VERB
biomedich-872	13	5	were	be	AUX
biomedich-872	13	6	asp184	asp184	NOUN
biomedich-872	13	7	and	and	CCONJ
biomedich-872	13	8	glu121	glu121	PROPN
biomedich-872	13	9	.	.	PUNCT
biomedich-872	14	1	the	the	DET
biomedich-872	14	2	redocking	redocking	NOUN
biomedich-872	14	3	rmsd	rmsd	NOUN
biomedich-872	14	4	value	value	NOUN
biomedich-872	14	5	of	of	ADP
biomedich-872	14	6	0.893	0.893	NUM
biomedich-872	14	7	å	å	PROPN
biomedich-872	14	8	confirmed	confirm	VERB
biomedich-872	14	9	methodological	methodological	ADJ
biomedich-872	14	10	accuracy	accuracy	NOUN
biomedich-872	14	11	.	.	PUNCT
biomedich-872	15	1	admet	admet	PROPN
biomedich-872	15	2	predictions	prediction	NOUN
biomedich-872	15	3	revealed	reveal	VERB
biomedich-872	15	4	high	high	ADJ
biomedich-872	15	5	intestinal	intestinal	ADJ
biomedich-872	15	6	absorption	absorption	NOUN
biomedich-872	15	7	for	for	ADP
biomedich-872	15	8	tangeretin	tangeretin	ADJ
biomedich-872	15	9	and	and	CCONJ
biomedich-872	15	10	apigenin	apigenin	ADJ
biomedich-872	15	11	,	,	PUNCT
biomedich-872	15	12	with	with	ADP
biomedich-872	15	13	no	no	DET
biomedich-872	15	14	mutagenic	mutagenic	ADJ
biomedich-872	15	15	or	or	CCONJ
biomedich-872	15	16	hepatotoxic	hepatotoxic	NOUN
biomedich-872	15	17	risks	risk	NOUN
biomedich-872	15	18	,	,	PUNCT
biomedich-872	15	19	indicating	indicate	VERB
biomedich-872	15	20	good	good	ADJ
biomedich-872	15	21	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	15	22	profiles	profile	NOUN
biomedich-872	15	23	.	.	PUNCT
biomedich-872	16	1	physalis	physali	NOUN
biomedich-872	16	2	angulata	angulata	ADJ
biomedich-872	16	3	flavonoids	flavonoid	NOUN
biomedich-872	16	4	exhibit	exhibit	VERB
biomedich-872	16	5	strong	strong	ADJ
biomedich-872	16	6	pi3k	pi3k	PROPN
biomedich-872	16	7	/	/	SYM
biomedich-872	16	8	akt	akt	PROPN
biomedich-872	16	9	binding	bind	VERB
biomedich-872	16	10	and	and	CCONJ
biomedich-872	16	11	favorable	favorable	ADJ
biomedich-872	16	12	pharmacokinetics	pharmacokinetic	NOUN
biomedich-872	16	13	,	,	PUNCT
biomedich-872	16	14	supporting	support	VERB
biomedich-872	16	15	their	their	PRON
biomedich-872	16	16	potential	potential	NOUN
biomedich-872	16	17	as	as	ADP
biomedich-872	16	18	antifibrotic	antifibrotic	ADJ
biomedich-872	16	19	agents	agent	NOUN
biomedich-872	16	20	.	.	PUNCT
biomedich-872	17	1	keywords	keyword	NOUN
biomedich-872	17	2	:	:	PUNCT
biomedich-872	17	3	pulmonary	pulmonary	ADJ
biomedich-872	17	4	fibrosis	fibrosis	NOUN
biomedich-872	17	5	:	:	PUNCT
biomedich-872	17	6	physalis	physalis	NOUN
biomedich-872	17	7	angulata	angulata	VERB
biomedich-872	17	8	;	;	PUNCT
biomedich-872	17	9	molecular	molecular	ADJ
biomedich-872	17	10	docking	docking	NOUN
biomedich-872	17	11	;	;	PUNCT
biomedich-872	17	12	pi3k	pi3k	PROPN
biomedich-872	17	13	/	/	SYM
biomedich-872	17	14	akt	akt	PROPN
biomedich-872	17	15	.	.	PUNCT
biomedich-872	18	1	introduction	introduction	NOUN
biomedich-872	18	2	pulmonary	pulmonary	ADJ
biomedich-872	18	3	fibrosis	fibrosis	NOUN
biomedich-872	18	4	is	be	AUX
biomedich-872	18	5	a	a	DET
biomedich-872	18	6	progressive	progressive	ADJ
biomedich-872	18	7	,	,	PUNCT
biomedich-872	18	8	chronic	chronic	ADJ
biomedich-872	18	9	interstitial	interstitial	ADJ
biomedich-872	18	10	lung	lung	NOUN
biomedich-872	18	11	disease	disease	NOUN
biomedich-872	18	12	characterized	characterize	VERB
biomedich-872	18	13	by	by	ADP
biomedich-872	18	14	the	the	DET
biomedich-872	18	15	excessive	excessive	ADJ
biomedich-872	18	16	accumulation	accumulation	NOUN
biomedich-872	18	17	of	of	ADP
biomedich-872	18	18	fibrotic	fibrotic	ADJ
biomedich-872	18	19	tissue	tissue	NOUN
biomedich-872	18	20	in	in	ADP
biomedich-872	18	21	the	the	DET
biomedich-872	18	22	lungs	lung	NOUN
biomedich-872	18	23	,	,	PUNCT
biomedich-872	18	24	leading	lead	VERB
biomedich-872	18	25	to	to	ADP
biomedich-872	18	26	a	a	DET
biomedich-872	18	27	steady	steady	ADJ
biomedich-872	18	28	decline	decline	NOUN
biomedich-872	18	29	in	in	ADP
biomedich-872	18	30	respiratory	respiratory	ADJ
biomedich-872	18	31	function	function	NOUN
biomedich-872	18	32	(	(	PUNCT
biomedich-872	18	33	mazurek	mazurek	NOUN
biomedich-872	18	34	et	et	PROPN
biomedich-872	18	35	al	al	PROPN
biomedich-872	18	36	.	.	PROPN
biomedich-872	18	37	,	,	PUNCT
biomedich-872	18	38	2025	2025	NUM
biomedich-872	18	39	)	)	PUNCT
biomedich-872	18	40	.	.	PUNCT
biomedich-872	19	1	among	among	ADP
biomedich-872	19	2	its	its	PRON
biomedich-872	19	3	various	various	ADJ
biomedich-872	19	4	forms	form	NOUN
biomedich-872	19	5	,	,	PUNCT
biomedich-872	19	6	idiopathic	idiopathic	ADJ
biomedich-872	19	7	pulmonary	pulmonary	ADJ
biomedich-872	19	8	fibrosis	fibrosis	NOUN
biomedich-872	19	9	(	(	PUNCT
biomedich-872	19	10	ipf	ipf	X
biomedich-872	19	11	)	)	PUNCT
biomedich-872	19	12	is	be	AUX
biomedich-872	19	13	the	the	DET
biomedich-872	19	14	most	most	ADV
biomedich-872	19	15	prevalent	prevalent	ADJ
biomedich-872	19	16	and	and	CCONJ
biomedich-872	19	17	severe	severe	ADJ
biomedich-872	19	18	,	,	PUNCT
biomedich-872	19	19	with	with	ADP
biomedich-872	19	20	a	a	DET
biomedich-872	19	21	reported	report	VERB
biomedich-872	19	22	incidence	incidence	NOUN
biomedich-872	19	23	of	of	ADP
biomedich-872	19	24	58.7	58.7	NUM
biomedich-872	19	25	cases	case	NOUN
biomedich-872	19	26	per	per	ADP
biomedich-872	19	27	100,000	100,000	NUM
biomedich-872	19	28	individuals	individual	NOUN
biomedich-872	19	29	.	.	PUNCT
biomedich-872	20	1	the	the	DET
biomedich-872	20	2	disease	disease	NOUN
biomedich-872	20	3	carries	carry	VERB
biomedich-872	20	4	a	a	DET
biomedich-872	20	5	high	high	ADJ
biomedich-872	20	6	mortality	mortality	NOUN
biomedich-872	20	7	rate	rate	NOUN
biomedich-872	20	8	,	,	PUNCT
biomedich-872	20	9	with	with	ADP
biomedich-872	20	10	an	an	DET
biomedich-872	20	11	age	age	NOUN
biomedich-872	20	12	-	-	PUNCT
biomedich-872	20	13	adjusted	adjust	VERB
biomedich-872	20	14	death	death	NOUN
biomedich-872	20	15	rate	rate	NOUN
biomedich-872	20	16	of	of	ADP
biomedich-872	20	17	5.4	5.4	NUM
biomedich-872	20	18	per	per	ADP
biomedich-872	20	19	100,000	100,000	NUM
biomedich-872	20	20	population	population	NOUN
biomedich-872	20	21	in	in	ADP
biomedich-872	20	22	2017	2017	NUM
biomedich-872	20	23	(	(	PUNCT
biomedich-872	20	24	zheng	zheng	PROPN
biomedich-872	20	25	et	et	PROPN
biomedich-872	20	26	al	al	PROPN
biomedich-872	20	27	.	.	PROPN
biomedich-872	20	28	,	,	PUNCT
biomedich-872	20	29	2022	2022	NUM
biomedich-872	20	30	)	)	PUNCT
biomedich-872	20	31	.	.	PUNCT
biomedich-872	21	1	although	although	SCONJ
biomedich-872	21	2	several	several	ADJ
biomedich-872	21	3	intrinsic	intrinsic	ADJ
biomedich-872	21	4	risk	risk	NOUN
biomedich-872	21	5	factors	factor	NOUN
biomedich-872	21	6	have	have	AUX
biomedich-872	21	7	been	be	AUX
biomedich-872	21	8	identified	identify	VERB
biomedich-872	21	9	,	,	PUNCT
biomedich-872	21	10	including	include	VERB
biomedich-872	21	11	genetic	genetic	ADJ
biomedich-872	21	12	predisposition	predisposition	NOUN
biomedich-872	21	13	,	,	PUNCT
biomedich-872	21	14	age	age	NOUN
biomedich-872	21	15	,	,	PUNCT
biomedich-872	21	16	sex	sex	NOUN
biomedich-872	21	17	,	,	PUNCT
biomedich-872	21	18	and	and	CCONJ
biomedich-872	21	19	alterations	alteration	NOUN
biomedich-872	21	20	in	in	ADP
biomedich-872	21	21	the	the	DET
biomedich-872	21	22	lung	lung	NOUN
biomedich-872	21	23	microbiome	microbiome	NOUN
biomedich-872	21	24	,	,	PUNCT
biomedich-872	21	25	as	as	ADV
biomedich-872	21	26	well	well	ADV
biomedich-872	21	27	as	as	ADP
biomedich-872	21	28	extrinsic	extrinsic	ADJ
biomedich-872	21	29	factors	factor	NOUN
biomedich-872	21	30	such	such	ADJ
biomedich-872	21	31	as	as	ADP
biomedich-872	21	32	cigarette	cigarette	NOUN
biomedich-872	21	33	smoke	smoke	NOUN
biomedich-872	21	34	,	,	PUNCT
biomedich-872	21	35	environmental	environmental	ADJ
biomedich-872	21	36	exposures	exposure	NOUN
biomedich-872	21	37	,	,	PUNCT
biomedich-872	21	38	and	and	CCONJ
biomedich-872	21	39	air	air	NOUN
biomedich-872	21	40	pollution	pollution	NOUN
biomedich-872	21	41	,	,	PUNCT
biomedich-872	21	42	the	the	DET
biomedich-872	21	43	exact	exact	ADJ
biomedich-872	21	44	etiology	etiology	NOUN
biomedich-872	21	45	of	of	ADP
biomedich-872	21	46	ipf	ipf	NOUN
biomedich-872	21	47	remains	remain	VERB
biomedich-872	21	48	elusive	elusive	ADJ
biomedich-872	21	49	(	(	PUNCT
biomedich-872	21	50	zaman	zaman	PROPN
biomedich-872	21	51	&	&	CCONJ
biomedich-872	21	52	lee	lee	PROPN
biomedich-872	21	53	,	,	PUNCT
biomedich-872	21	54	2018	2018	NUM
biomedich-872	21	55	)	)	PUNCT
biomedich-872	21	56	.	.	PUNCT
biomedich-872	22	1	comorbid	comorbid	NOUN
biomedich-872	22	2	conditions	condition	NOUN
biomedich-872	22	3	like	like	ADP
biomedich-872	22	4	gastroesophageal	gastroesophageal	NOUN
biomedich-872	22	5	reflux	reflux	NOUN
biomedich-872	22	6	disease	disease	NOUN
biomedich-872	22	7	,	,	PUNCT
biomedich-872	22	8	obstructive	obstructive	ADJ
biomedich-872	22	9	sleep	sleep	NOUN
biomedich-872	22	10	apnea	apnea	NOUN
biomedich-872	22	11	,	,	PUNCT
biomedich-872	22	12	diabetes	diabetes	NOUN
biomedich-872	22	13	mellitus	mellitus	NOUN
biomedich-872	22	14	,	,	PUNCT
biomedich-872	22	15	and	and	CCONJ
biomedich-872	22	16	viral	viral	ADJ
biomedich-872	22	17	infections	infection	NOUN
biomedich-872	22	18	have	have	AUX
biomedich-872	22	19	also	also	ADV
biomedich-872	22	20	been	be	AUX
biomedich-872	22	21	linked	link	VERB
biomedich-872	22	22	to	to	ADP
biomedich-872	22	23	the	the	DET
biomedich-872	22	24	disease	disease	NOUN
biomedich-872	22	25	(	(	PUNCT
biomedich-872	22	26	alfaro	alfaro	PROPN
biomedich-872	22	27	&	&	CCONJ
biomedich-872	22	28	robalo	robalo	PROPN
biomedich-872	22	29	cordeiro	cordeiro	PROPN
biomedich-872	22	30	,	,	PUNCT
biomedich-872	22	31	2020	2020	NUM
biomedich-872	22	32	)	)	PUNCT
biomedich-872	22	33	.	.	PUNCT
biomedich-872	23	1	clinically	clinically	ADV
biomedich-872	23	2	,	,	PUNCT
biomedich-872	23	3	patients	patient	NOUN
biomedich-872	23	4	with	with	ADP
biomedich-872	23	5	pulmonary	pulmonary	ADJ
biomedich-872	23	6	fibrosis	fibrosis	NOUN
biomedich-872	23	7	often	often	ADV
biomedich-872	23	8	present	present	VERB
biomedich-872	23	9	with	with	ADP
biomedich-872	23	10	non	non	ADJ
biomedich-872	23	11	-	-	ADJ
biomedich-872	23	12	specific	specific	ADJ
biomedich-872	23	13	symptoms	symptom	NOUN
biomedich-872	23	14	such	such	ADJ
biomedich-872	23	15	as	as	ADP
biomedich-872	23	16	exertional	exertional	ADJ
biomedich-872	23	17	dyspnea	dyspnea	NOUN
biomedich-872	23	18	and	and	CCONJ
biomedich-872	23	19	chronic	chronic	ADJ
biomedich-872	23	20	cough	cough	NOUN
biomedich-872	23	21	,	,	PUNCT
biomedich-872	23	22	which	which	PRON
biomedich-872	23	23	can	can	AUX
biomedich-872	23	24	delay	delay	VERB
biomedich-872	23	25	diagnosis	diagnosis	NOUN
biomedich-872	23	26	(	(	PUNCT
biomedich-872	23	27	martinez	martinez	PROPN
biomedich-872	23	28	et	et	PROPN
biomedich-872	23	29	al	al	PROPN
biomedich-872	23	30	.	.	PROPN
biomedich-872	23	31	,	,	PUNCT
biomedich-872	23	32	2017	2017	NUM
biomedich-872	23	33	)	)	PUNCT
biomedich-872	23	34	.	.	PUNCT
biomedich-872	24	1	a	a	DET
biomedich-872	24	2	detailed	detailed	ADJ
biomedich-872	24	3	clinical	clinical	ADJ
biomedich-872	24	4	history	history	NOUN
biomedich-872	24	5	is	be	AUX
biomedich-872	24	6	essential	essential	ADJ
biomedich-872	24	7	and	and	CCONJ
biomedich-872	24	8	should	should	AUX
biomedich-872	24	9	include	include	VERB
biomedich-872	24	10	information	information	NOUN
biomedich-872	24	11	on	on	ADP
biomedich-872	24	12	environmental	environmental	ADJ
biomedich-872	24	13	exposures	exposure	NOUN
biomedich-872	24	14	,	,	PUNCT
biomedich-872	24	15	smoking	smoking	NOUN
biomedich-872	24	16	habits	habit	NOUN
biomedich-872	24	17	,	,	PUNCT
biomedich-872	24	18	prior	prior	ADJ
biomedich-872	24	19	treatments	treatment	NOUN
biomedich-872	24	20	,	,	PUNCT
biomedich-872	24	21	illicit	illicit	ADJ
biomedich-872	24	22	drug	drug	NOUN
biomedich-872	24	23	use	use	NOUN
biomedich-872	24	24	,	,	PUNCT
biomedich-872	24	25	travel	travel	NOUN
biomedich-872	24	26	history	history	NOUN
biomedich-872	24	27	,	,	PUNCT
biomedich-872	24	28	and	and	CCONJ
biomedich-872	24	29	familial	familial	ADJ
biomedich-872	24	30	cases	case	NOUN
biomedich-872	24	31	of	of	ADP
biomedich-872	24	32	lung	lung	NOUN
biomedich-872	24	33	disease	disease	NOUN
biomedich-872	24	34	.	.	PUNCT
biomedich-872	25	1	to	to	PART
biomedich-872	25	2	aid	aid	VERB
biomedich-872	25	3	this	this	DET
biomedich-872	25	4	process	process	NOUN
biomedich-872	25	5	,	,	PUNCT
biomedich-872	25	6	the	the	DET
biomedich-872	25	7	german	german	ADJ
biomedich-872	25	8	respiratory	respiratory	ADJ
biomedich-872	25	9	society	society	NOUN
biomedich-872	25	10	has	have	AUX
biomedich-872	25	11	developed	develop	VERB
biomedich-872	25	12	a	a	DET
biomedich-872	25	13	standardized	standardized	ADJ
biomedich-872	25	14	patient	patient	ADJ
biomedich-872	25	15	questionnaire	questionnaire	NOUN
biomedich-872	25	16	that	that	PRON
biomedich-872	25	17	enhances	enhance	VERB
biomedich-872	25	18	the	the	DET
biomedich-872	25	19	accuracy	accuracy	NOUN
biomedich-872	25	20	and	and	CCONJ
biomedich-872	25	21	comprehensiveness	comprehensiveness	NOUN
biomedich-872	25	22	of	of	ADP
biomedich-872	25	23	evaluations	evaluation	NOUN
biomedich-872	25	24	(	(	PUNCT
biomedich-872	25	25	kardos	kardo	NOUN
biomedich-872	25	26	et	et	PROPN
biomedich-872	25	27	al	al	PROPN
biomedich-872	25	28	.	.	PROPN
biomedich-872	25	29	,	,	PUNCT
biomedich-872	25	30	2020	2020	NUM
biomedich-872	25	31	)	)	PUNCT
biomedich-872	25	32	.	.	PUNCT
biomedich-872	26	1	diagnostic	diagnostic	ADJ
biomedich-872	26	2	confirmation	confirmation	NOUN
biomedich-872	26	3	typically	typically	ADV
biomedich-872	26	4	relies	rely	VERB
biomedich-872	26	5	on	on	ADP
biomedich-872	26	6	an	an	DET
biomedich-872	26	7	integrative	integrative	ADJ
biomedich-872	26	8	assessment	assessment	NOUN
biomedich-872	26	9	involving	involve	VERB
biomedich-872	26	10	clinical	clinical	ADJ
biomedich-872	26	11	evaluation	evaluation	NOUN
biomedich-872	26	12	,	,	PUNCT
biomedich-872	26	13	imaging	image	VERB
biomedich-872	26	14	such	such	ADJ
biomedich-872	26	15	as	as	ADP
biomedich-872	26	16	high	high	ADJ
biomedich-872	26	17	-	-	PUNCT
biomedich-872	26	18	resolution	resolution	NOUN
biomedich-872	26	19	ct	ct	NUM
biomedich-872	26	20	scans	scan	NOUN
biomedich-872	26	21	,	,	PUNCT
biomedich-872	26	22	and	and	CCONJ
biomedich-872	26	23	,	,	PUNCT
biomedich-872	26	24	in	in	ADP
biomedich-872	26	25	certain	certain	ADJ
biomedich-872	26	26	cases	case	NOUN
biomedich-872	26	27	,	,	PUNCT
biomedich-872	26	28	histopathological	histopathological	ADJ
biomedich-872	26	29	examination	examination	NOUN
biomedich-872	26	30	(	(	PUNCT
biomedich-872	26	31	lee	lee	PROPN
biomedich-872	26	32	&	&	CCONJ
biomedich-872	26	33	song	song	PROPN
biomedich-872	26	34	,	,	PUNCT
biomedich-872	26	35	2024	2024	NUM
biomedich-872	26	36	)	)	PUNCT
biomedich-872	26	37	.	.	PUNCT
biomedich-872	27	1	currently	currently	ADV
biomedich-872	27	2	,	,	PUNCT
biomedich-872	27	3	pirfenidone	pirfenidone	NOUN
biomedich-872	27	4	and	and	CCONJ
biomedich-872	27	5	nintedanib	nintedanib	NOUN
biomedich-872	27	6	are	be	AUX
biomedich-872	27	7	the	the	DET
biomedich-872	27	8	only	only	ADJ
biomedich-872	27	9	antifibrotic	antifibrotic	ADJ
biomedich-872	27	10	agents	agent	NOUN
biomedich-872	27	11	approved	approve	VERB
biomedich-872	27	12	for	for	ADP
biomedich-872	27	13	ipf	ipf	NOUN
biomedich-872	27	14	management	management	NOUN
biomedich-872	27	15	.	.	PUNCT
biomedich-872	28	1	although	although	SCONJ
biomedich-872	28	2	both	both	DET
biomedich-872	28	3	drugs	drug	NOUN
biomedich-872	28	4	have	have	AUX
biomedich-872	28	5	demonstrated	demonstrate	VERB
biomedich-872	28	6	efficacy	efficacy	NOUN
biomedich-872	28	7	in	in	ADP
biomedich-872	28	8	slowing	slow	VERB
biomedich-872	28	9	disease	disease	NOUN
biomedich-872	28	10	progression	progression	NOUN
biomedich-872	28	11	,	,	PUNCT
biomedich-872	28	12	their	their	PRON
biomedich-872	28	13	use	use	NOUN
biomedich-872	28	14	is	be	AUX
biomedich-872	28	15	often	often	ADV
biomedich-872	28	16	limited	limit	VERB
biomedich-872	28	17	by	by	ADP
biomedich-872	28	18	side	side	NOUN
biomedich-872	28	19	effects	effect	NOUN
biomedich-872	28	20	,	,	PUNCT
biomedich-872	28	21	including	include	VERB
biomedich-872	28	22	gastrointestinal	gastrointestinal	ADJ
biomedich-872	28	23	disturbances	disturbance	NOUN
biomedich-872	28	24	and	and	CCONJ
biomedich-872	28	25	hepatotoxicity	hepatotoxicity	NOUN
biomedich-872	28	26	,	,	PUNCT
biomedich-872	28	27	necessitating	necessitate	VERB
biomedich-872	28	28	regular	regular	ADJ
biomedich-872	28	29	liver	liver	NOUN
biomedich-872	28	30	function	function	NOUN
biomedich-872	28	31	monitoring	monitoring	NOUN
biomedich-872	28	32	(	(	PUNCT
biomedich-872	28	33	glass	glass	NOUN
biomedich-872	28	34	et	et	PROPN
biomedich-872	28	35	al	al	PROPN
biomedich-872	28	36	.	.	PROPN
biomedich-872	28	37	,	,	PUNCT
biomedich-872	28	38	2022	2022	NUM
biomedich-872	28	39	)	)	PUNCT
biomedich-872	28	40	.	.	PUNCT
biomedich-872	29	1	in	in	ADP
biomedich-872	29	2	light	light	NOUN
biomedich-872	29	3	of	of	ADP
biomedich-872	29	4	these	these	DET
biomedich-872	29	5	limitations	limitation	NOUN
biomedich-872	29	6	,	,	PUNCT
biomedich-872	29	7	interest	interest	NOUN
biomedich-872	29	8	in	in	ADP
biomedich-872	29	9	plant	plant	NOUN
biomedich-872	29	10	-	-	PUNCT
biomedich-872	29	11	based	base	VERB
biomedich-872	29	12	therapies	therapy	NOUN
biomedich-872	29	13	has	have	AUX
biomedich-872	29	14	grown	grow	VERB
biomedich-872	29	15	,	,	PUNCT
biomedich-872	29	16	with	with	ADP
biomedich-872	29	17	physalis	physali	NOUN
biomedich-872	29	18	angulata	angulata	VERB
biomedich-872	29	19	emerging	emerge	VERB
biomedich-872	29	20	as	as	ADP
biomedich-872	29	21	a	a	DET
biomedich-872	29	22	promising	promising	ADJ
biomedich-872	29	23	natural	natural	ADJ
biomedich-872	29	24	candidate	candidate	NOUN
biomedich-872	29	25	.	.	PUNCT
biomedich-872	30	1	commonly	commonly	ADV
biomedich-872	30	2	known	know	VERB
biomedich-872	30	3	as	as	SCONJ
biomedich-872	30	4	manuscript	manuscript	NOUN
biomedich-872	30	5	received	receive	VERB
biomedich-872	30	6	:	:	PUNCT
biomedich-872	30	7	13	13	NUM
biomedich-872	30	8	july	july	NOUN
biomedich-872	30	9	,	,	PUNCT
biomedich-872	30	10	2025	2025	NUM
biomedich-872	30	11	.	.	PUNCT
biomedich-872	31	1	revision	revision	NOUN
biomedich-872	31	2	accepted	accept	VERB
biomedich-872	31	3	:	:	PUNCT
biomedich-872	31	4	02	02	NUM
biomedich-872	31	5	october	october	PROPN
biomedich-872	31	6	,	,	PUNCT
biomedich-872	31	7	2025	2025	NUM
biomedich-872	31	8	.	.	PUNCT
biomedich-872	32	1	published	publish	VERB
biomedich-872	32	2	:	:	PUNCT
biomedich-872	32	3	17	17	NUM
biomedich-872	32	4	october	october	PROPN
biomedich-872	32	5	,	,	PUNCT
biomedich-872	32	6	2025	2025	NUM
biomedich-872	32	7	.	.	PUNCT
biomedich-872	33	1	https://doi.org/10.14421/biomedich.2025.142.817-824	https://doi.org/10.14421/biomedich.2025.142.817-824	PRON
biomedich-872	33	2	mailto:muhammad2100034023@webmail.uad.ac.id	mailto:muhammad2100034023@webmail.uad.ac.id	NOUN
biomedich-872	33	3	818	818	NUM
biomedich-872	33	4	biology	biology	NOUN
biomedich-872	33	5	,	,	PUNCT
biomedich-872	33	6	medicine	medicine	NOUN
biomedich-872	33	7	,	,	PUNCT
biomedich-872	33	8	&	&	CCONJ
biomedich-872	33	9	natural	natural	ADJ
biomedich-872	33	10	product	product	NOUN
biomedich-872	33	11	chemistry	chemistry	NOUN
biomedich-872	33	12	14	14	NUM
biomedich-872	33	13	(	(	PUNCT
biomedich-872	33	14	2	2	NUM
biomedich-872	33	15	)	)	PUNCT
biomedich-872	33	16	,	,	PUNCT
biomedich-872	33	17	2025	2025	NUM
biomedich-872	33	18	:	:	PUNCT
biomedich-872	33	19	817	817	NUM
biomedich-872	33	20	-	-	SYM
biomedich-872	33	21	824	824	NUM
biomedich-872	33	22	ciplukan	ciplukan	VERB
biomedich-872	33	23	in	in	ADP
biomedich-872	33	24	indonesia	indonesia	PROPN
biomedich-872	33	25	,	,	PUNCT
biomedich-872	33	26	this	this	DET
biomedich-872	33	27	plant	plant	NOUN
biomedich-872	33	28	is	be	AUX
biomedich-872	33	29	traditionally	traditionally	ADV
biomedich-872	33	30	used	use	VERB
biomedich-872	33	31	to	to	PART
biomedich-872	33	32	treat	treat	VERB
biomedich-872	33	33	various	various	ADJ
biomedich-872	33	34	ailments	ailment	NOUN
biomedich-872	33	35	,	,	PUNCT
biomedich-872	33	36	including	include	VERB
biomedich-872	33	37	diabetes	diabetes	NOUN
biomedich-872	33	38	,	,	PUNCT
biomedich-872	33	39	hepatitis	hepatitis	NOUN
biomedich-872	33	40	,	,	PUNCT
biomedich-872	33	41	and	and	CCONJ
biomedich-872	33	42	asthma	asthma	NOUN
biomedich-872	33	43	(	(	PUNCT
biomedich-872	33	44	prasetyo	prasetyo	NOUN
biomedich-872	33	45	&	&	CCONJ
biomedich-872	33	46	purwanti	purwanti	NOUN
biomedich-872	33	47	,	,	PUNCT
biomedich-872	33	48	2024	2024	NUM
biomedich-872	33	49	)	)	PUNCT
biomedich-872	33	50	.	.	PUNCT
biomedich-872	34	1	pharmacological	pharmacological	ADJ
biomedich-872	34	2	studies	study	NOUN
biomedich-872	34	3	have	have	AUX
biomedich-872	34	4	shown	show	VERB
biomedich-872	34	5	that	that	SCONJ
biomedich-872	34	6	p.	p.	NOUN
biomedich-872	34	7	angulata	angulata	ADJ
biomedich-872	34	8	possesses	possess	VERB
biomedich-872	34	9	diverse	diverse	ADJ
biomedich-872	34	10	biological	biological	ADJ
biomedich-872	34	11	activities	activity	NOUN
biomedich-872	34	12	,	,	PUNCT
biomedich-872	34	13	such	such	ADJ
biomedich-872	34	14	as	as	ADP
biomedich-872	34	15	antioxidant	antioxidant	NOUN
biomedich-872	34	16	,	,	PUNCT
biomedich-872	34	17	antiinflammatory	antiinflammatory	NOUN
biomedich-872	34	18	,	,	PUNCT
biomedich-872	34	19	anticancer	anticancer	NOUN
biomedich-872	34	20	,	,	PUNCT
biomedich-872	34	21	antidiabetic	antidiabetic	ADJ
biomedich-872	34	22	,	,	PUNCT
biomedich-872	34	23	and	and	CCONJ
biomedich-872	34	24	antibacterial	antibacterial	ADJ
biomedich-872	34	25	effects	effect	NOUN
biomedich-872	34	26	(	(	PUNCT
biomedich-872	34	27	fadhli	fadhli	ADV
biomedich-872	34	28	et	et	PROPN
biomedich-872	34	29	al	al	PROPN
biomedich-872	34	30	.	.	PROPN
biomedich-872	34	31	,	,	PUNCT
biomedich-872	34	32	2023	2023	NUM
biomedich-872	34	33	)	)	PUNCT
biomedich-872	34	34	.	.	PUNCT
biomedich-872	35	1	the	the	DET
biomedich-872	35	2	plant	plant	NOUN
biomedich-872	35	3	is	be	AUX
biomedich-872	35	4	well	well	ADV
biomedich-872	35	5	adapted	adapt	VERB
biomedich-872	35	6	to	to	ADP
biomedich-872	35	7	tropical	tropical	ADJ
biomedich-872	35	8	climates	climate	NOUN
biomedich-872	35	9	and	and	CCONJ
biomedich-872	35	10	grows	grow	VERB
biomedich-872	35	11	wild	wild	ADJ
biomedich-872	35	12	across	across	ADP
biomedich-872	35	13	much	much	ADJ
biomedich-872	35	14	of	of	ADP
biomedich-872	35	15	indonesia	indonesia	PROPN
biomedich-872	35	16	,	,	PUNCT
biomedich-872	35	17	making	make	VERB
biomedich-872	35	18	it	it	PRON
biomedich-872	35	19	easily	easily	ADV
biomedich-872	35	20	accessible	accessible	ADJ
biomedich-872	35	21	for	for	ADP
biomedich-872	35	22	cultivation	cultivation	NOUN
biomedich-872	35	23	and	and	CCONJ
biomedich-872	35	24	medicinal	medicinal	ADJ
biomedich-872	35	25	use	use	NOUN
biomedich-872	35	26	(	(	PUNCT
biomedich-872	35	27	pillai	pillai	PROPN
biomedich-872	35	28	et	et	PROPN
biomedich-872	35	29	al	al	PROPN
biomedich-872	35	30	.	.	PROPN
biomedich-872	35	31	,	,	PUNCT
biomedich-872	35	32	2022	2022	NUM
biomedich-872	35	33	)	)	PUNCT
biomedich-872	35	34	.	.	PUNCT
biomedich-872	36	1	furthermore	furthermore	ADV
biomedich-872	36	2	,	,	PUNCT
biomedich-872	36	3	subacute	subacute	VERB
biomedich-872	36	4	toxicity	toxicity	NOUN
biomedich-872	36	5	studies	study	NOUN
biomedich-872	36	6	have	have	AUX
biomedich-872	36	7	confirmed	confirm	VERB
biomedich-872	36	8	its	its	PRON
biomedich-872	36	9	safety	safety	NOUN
biomedich-872	36	10	profile	profile	NOUN
biomedich-872	36	11	,	,	PUNCT
biomedich-872	36	12	supporting	support	VERB
biomedich-872	36	13	its	its	PRON
biomedich-872	36	14	suitability	suitability	NOUN
biomedich-872	36	15	for	for	ADP
biomedich-872	36	16	development	development	NOUN
biomedich-872	36	17	as	as	ADP
biomedich-872	36	18	a	a	DET
biomedich-872	36	19	herbal	herbal	ADJ
biomedich-872	36	20	medicinal	medicinal	ADJ
biomedich-872	36	21	product	product	NOUN
biomedich-872	36	22	.	.	PUNCT
biomedich-872	37	1	its	its	PRON
biomedich-872	37	2	wide	wide	ADJ
biomedich-872	37	3	geographic	geographic	ADJ
biomedich-872	37	4	distribution	distribution	NOUN
biomedich-872	37	5	across	across	ADP
biomedich-872	37	6	asia	asia	PROPN
biomedich-872	37	7	,	,	PUNCT
biomedich-872	37	8	the	the	DET
biomedich-872	37	9	americas	americas	PROPN
biomedich-872	37	10	,	,	PUNCT
biomedich-872	37	11	australia	australia	PROPN
biomedich-872	37	12	,	,	PUNCT
biomedich-872	37	13	and	and	CCONJ
biomedich-872	37	14	the	the	DET
biomedich-872	37	15	pacific	pacific	PROPN
biomedich-872	37	16	further	far	ADV
biomedich-872	37	17	underscores	underscore	VERB
biomedich-872	37	18	its	its	PRON
biomedich-872	37	19	global	global	ADJ
biomedich-872	37	20	therapeutic	therapeutic	ADJ
biomedich-872	37	21	potential	potential	NOUN
biomedich-872	37	22	.	.	PUNCT
biomedich-872	38	1	the	the	DET
biomedich-872	38	2	therapeutic	therapeutic	ADJ
biomedich-872	38	3	properties	property	NOUN
biomedich-872	38	4	of	of	ADP
biomedich-872	38	5	p.	p.	NOUN
biomedich-872	38	6	angulata	angulata	NOUN
biomedich-872	38	7	are	be	AUX
biomedich-872	38	8	largely	largely	ADV
biomedich-872	38	9	attributed	attribute	VERB
biomedich-872	38	10	to	to	ADP
biomedich-872	38	11	its	its	PRON
biomedich-872	38	12	rich	rich	ADJ
biomedich-872	38	13	content	content	NOUN
biomedich-872	38	14	of	of	ADP
biomedich-872	38	15	withanolide	withanolide	NOUN
biomedich-872	38	16	compounds	compound	NOUN
biomedich-872	38	17	.	.	PUNCT
biomedich-872	39	1	recent	recent	ADJ
biomedich-872	39	2	investigations	investigation	NOUN
biomedich-872	39	3	have	have	AUX
biomedich-872	39	4	identified	identify	VERB
biomedich-872	39	5	eight	eight	NUM
biomedich-872	39	6	novel	novel	NOUN
biomedich-872	39	7	withanolides	withanolide	NOUN
biomedich-872	39	8	designated	designate	VERB
biomedich-872	39	9	withagulides	withagulide	NOUN
biomedich-872	40	1	a	a	PRON
biomedich-872	40	2	through	through	ADP
biomedich-872	40	3	h	h	NOUN
biomedich-872	40	4	alongside	alongside	ADP
biomedich-872	40	5	twenty	twenty	NUM
biomedich-872	40	6	-	-	PUNCT
biomedich-872	40	7	eight	eight	NUM
biomedich-872	40	8	known	know	VERB
biomedich-872	40	9	analogues	analogue	NOUN
biomedich-872	40	10	(	(	PUNCT
biomedich-872	40	11	novitasari	novitasari	PROPN
biomedich-872	40	12	et	et	PROPN
biomedich-872	40	13	al	al	PROPN
biomedich-872	40	14	.	.	PROPN
biomedich-872	40	15	,	,	PUNCT
biomedich-872	40	16	2024	2024	NUM
biomedich-872	40	17	)	)	PUNCT
biomedich-872	40	18	.	.	PUNCT
biomedich-872	41	1	among	among	ADP
biomedich-872	41	2	these	these	PRON
biomedich-872	41	3	,	,	PUNCT
biomedich-872	41	4	several	several	ADJ
biomedich-872	41	5	compounds	compound	NOUN
biomedich-872	41	6	have	have	AUX
biomedich-872	41	7	shown	show	VERB
biomedich-872	41	8	potent	potent	ADJ
biomedich-872	41	9	antifibrotic	antifibrotic	ADJ
biomedich-872	41	10	activity	activity	NOUN
biomedich-872	41	11	,	,	PUNCT
biomedich-872	41	12	notably	notably	ADV
biomedich-872	41	13	by	by	ADP
biomedich-872	41	14	inhibiting	inhibit	VERB
biomedich-872	41	15	col1a1	col1a1	NOUN
biomedich-872	41	16	gene	gene	NOUN
biomedich-872	41	17	expression	expression	NOUN
biomedich-872	41	18	by	by	ADP
biomedich-872	41	19	over	over	ADP
biomedich-872	41	20	50	50	NUM
biomedich-872	41	21	%	%	NOUN
biomedich-872	41	22	(	(	PUNCT
biomedich-872	41	23	zhou	zhou	PROPN
biomedich-872	41	24	et	et	PROPN
biomedich-872	41	25	al	al	PROPN
biomedich-872	41	26	.	.	PROPN
biomedich-872	41	27	,	,	PUNCT
biomedich-872	41	28	2024	2024	NUM
biomedich-872	41	29	)	)	PUNCT
biomedich-872	41	30	.	.	PUNCT
biomedich-872	42	1	one	one	NUM
biomedich-872	42	2	compound	compound	NOUN
biomedich-872	42	3	,	,	PUNCT
biomedich-872	42	4	physalin	physalin	PROPN
biomedich-872	42	5	f	f	AUX
biomedich-872	42	6	,	,	PUNCT
biomedich-872	42	7	has	have	AUX
biomedich-872	42	8	been	be	AUX
biomedich-872	42	9	found	find	VERB
biomedich-872	42	10	to	to	PART
biomedich-872	42	11	significantly	significantly	ADV
biomedich-872	42	12	suppress	suppress	VERB
biomedich-872	42	13	collagen	collagen	NOUN
biomedich-872	42	14	i	i	PROPN
biomedich-872	42	15	and	and	CCONJ
biomedich-872	42	16	α	α	NOUN
biomedich-872	42	17	-	-	PUNCT
biomedich-872	42	18	sma	sma	NOUN
biomedich-872	42	19	expression	expression	NOUN
biomedich-872	42	20	induced	induce	VERB
biomedich-872	42	21	by	by	ADP
biomedich-872	42	22	tgf	tgf	PROPN
biomedich-872	42	23	-	-	PUNCT
biomedich-872	42	24	β1	β1	PROPN
biomedich-872	42	25	in	in	ADP
biomedich-872	42	26	hepatic	hepatic	ADJ
biomedich-872	42	27	stellate	stellate	ADJ
biomedich-872	42	28	cells	cell	NOUN
biomedich-872	42	29	,	,	PUNCT
biomedich-872	42	30	primarily	primarily	ADV
biomedich-872	42	31	through	through	ADP
biomedich-872	42	32	inhibition	inhibition	NOUN
biomedich-872	42	33	of	of	ADP
biomedich-872	42	34	the	the	DET
biomedich-872	42	35	pi3k	pi3k	PROPN
biomedich-872	42	36	/	/	SYM
biomedich-872	42	37	akt	akt	PROPN
biomedich-872	42	38	/	/	SYM
biomedich-872	42	39	mtor	mtor	PROPN
biomedich-872	42	40	signalling	signal	VERB
biomedich-872	42	41	pathway	pathway	NOUN
biomedich-872	42	42	(	(	PUNCT
biomedich-872	42	43	wang	wang	PROPN
biomedich-872	42	44	et	et	PROPN
biomedich-872	42	45	al	al	PROPN
biomedich-872	42	46	.	.	PROPN
biomedich-872	42	47	,	,	PUNCT
biomedich-872	42	48	2022	2022	NUM
biomedich-872	42	49	)	)	PUNCT
biomedich-872	42	50	.	.	PUNCT
biomedich-872	43	1	this	this	DET
biomedich-872	43	2	pathway	pathway	NOUN
biomedich-872	43	3	is	be	AUX
biomedich-872	43	4	known	know	VERB
biomedich-872	43	5	to	to	PART
biomedich-872	43	6	play	play	VERB
biomedich-872	43	7	a	a	DET
biomedich-872	43	8	central	central	ADJ
biomedich-872	43	9	role	role	NOUN
biomedich-872	43	10	in	in	ADP
biomedich-872	43	11	cellular	cellular	ADJ
biomedich-872	43	12	proliferation	proliferation	NOUN
biomedich-872	43	13	,	,	PUNCT
biomedich-872	43	14	fibrosis	fibrosis	NOUN
biomedich-872	43	15	progression	progression	NOUN
biomedich-872	43	16	,	,	PUNCT
biomedich-872	43	17	and	and	CCONJ
biomedich-872	43	18	scar	scar	ADJ
biomedich-872	43	19	tissue	tissue	NOUN
biomedich-872	43	20	formation	formation	NOUN
biomedich-872	43	21	.	.	PUNCT
biomedich-872	44	1	additionally	additionally	ADV
biomedich-872	44	2	,	,	PUNCT
biomedich-872	44	3	the	the	DET
biomedich-872	44	4	plant	plant	NOUN
biomedich-872	44	5	exerts	exert	VERB
biomedich-872	44	6	anti	anti	ADJ
biomedich-872	44	7	-	-	ADJ
biomedich-872	44	8	inflammatory	inflammatory	ADJ
biomedich-872	44	9	effects	effect	NOUN
biomedich-872	44	10	by	by	ADP
biomedich-872	44	11	reducing	reduce	VERB
biomedich-872	44	12	il-6	il-6	NUM
biomedich-872	44	13	gene	gene	NOUN
biomedich-872	44	14	expression	expression	NOUN
biomedich-872	44	15	in	in	ADP
biomedich-872	44	16	tgf	tgf	PROPN
biomedich-872	44	17	-	-	PUNCT
biomedich-872	44	18	β	β	NOUN
biomedich-872	44	19	-	-	ADJ
biomedich-872	44	20	induced	induce	VERB
biomedich-872	44	21	fibrotic	fibrotic	ADJ
biomedich-872	44	22	cells	cell	NOUN
biomedich-872	44	23	,	,	PUNCT
biomedich-872	44	24	suggesting	suggest	VERB
biomedich-872	44	25	its	its	PRON
biomedich-872	44	26	potential	potential	ADJ
biomedich-872	44	27	dual	dual	ADJ
biomedich-872	44	28	action	action	NOUN
biomedich-872	44	29	as	as	ADP
biomedich-872	44	30	both	both	CCONJ
biomedich-872	44	31	an	an	DET
biomedich-872	44	32	antifibrotic	antifibrotic	ADJ
biomedich-872	44	33	and	and	CCONJ
biomedich-872	44	34	anti	anti	ADJ
biomedich-872	44	35	-	-	ADJ
biomedich-872	44	36	inflammatory	inflammatory	ADJ
biomedich-872	44	37	agent	agent	NOUN
biomedich-872	44	38	(	(	PUNCT
biomedich-872	44	39	wiraswati	wiraswati	PROPN
biomedich-872	44	40	et	et	PROPN
biomedich-872	44	41	al	al	PROPN
biomedich-872	44	42	.	.	PROPN
biomedich-872	44	43	,	,	PUNCT
biomedich-872	44	44	2024	2024	NUM
biomedich-872	44	45	)	)	PUNCT
biomedich-872	44	46	.	.	PUNCT
biomedich-872	45	1	this	this	DET
biomedich-872	45	2	study	study	NOUN
biomedich-872	45	3	aims	aim	VERB
biomedich-872	45	4	to	to	PART
biomedich-872	45	5	explore	explore	VERB
biomedich-872	45	6	the	the	DET
biomedich-872	45	7	antifibrotic	antifibrotic	ADJ
biomedich-872	45	8	potential	potential	NOUN
biomedich-872	45	9	of	of	ADP
biomedich-872	45	10	physalis	physali	NOUN
biomedich-872	45	11	angulata	angulata	VERB
biomedich-872	45	12	through	through	ADP
biomedich-872	45	13	molecular	molecular	ADJ
biomedich-872	45	14	docking	docking	NOUN
biomedich-872	45	15	analysis	analysis	NOUN
biomedich-872	45	16	,	,	PUNCT
biomedich-872	45	17	targeting	target	VERB
biomedich-872	45	18	the	the	DET
biomedich-872	45	19	pi3k	pi3k	PROPN
biomedich-872	45	20	/	/	SYM
biomedich-872	45	21	akt	akt	PROPN
biomedich-872	45	22	signalling	signal	VERB
biomedich-872	45	23	pathway	pathway	NOUN
biomedich-872	45	24	.	.	PUNCT
biomedich-872	46	1	this	this	DET
biomedich-872	46	2	pathway	pathway	NOUN
biomedich-872	46	3	is	be	AUX
biomedich-872	46	4	critically	critically	ADV
biomedich-872	46	5	involved	involve	VERB
biomedich-872	46	6	in	in	ADP
biomedich-872	46	7	the	the	DET
biomedich-872	46	8	activation	activation	NOUN
biomedich-872	46	9	of	of	ADP
biomedich-872	46	10	fibrotic	fibrotic	ADJ
biomedich-872	46	11	cells	cell	NOUN
biomedich-872	46	12	and	and	CCONJ
biomedich-872	46	13	the	the	DET
biomedich-872	46	14	regulation	regulation	NOUN
biomedich-872	46	15	of	of	ADP
biomedich-872	46	16	genes	gene	NOUN
biomedich-872	46	17	associated	associate	VERB
biomedich-872	46	18	with	with	ADP
biomedich-872	46	19	extracellular	extracellular	ADJ
biomedich-872	46	20	matrix	matrix	NOUN
biomedich-872	46	21	production	production	NOUN
biomedich-872	46	22	and	and	CCONJ
biomedich-872	46	23	tissue	tissue	NOUN
biomedich-872	46	24	scarring	scarring	NOUN
biomedich-872	46	25	.	.	PUNCT
biomedich-872	47	1	through	through	ADP
biomedich-872	47	2	computationally	computationally	ADV
biomedich-872	47	3	screening	screen	VERB
biomedich-872	47	4	the	the	DET
biomedich-872	47	5	interaction	interaction	NOUN
biomedich-872	47	6	between	between	ADP
biomedich-872	47	7	bioactive	bioactive	ADJ
biomedich-872	47	8	compounds	compound	NOUN
biomedich-872	47	9	from	from	ADP
biomedich-872	47	10	p.	p.	NOUN
biomedich-872	47	11	angulata	angulata	NOUN
biomedich-872	47	12	and	and	CCONJ
biomedich-872	47	13	the	the	DET
biomedich-872	47	14	pi3k	pi3k	PROPN
biomedich-872	47	15	/	/	SYM
biomedich-872	47	16	akt	akt	PROPN
biomedich-872	47	17	protein	protein	NOUN
biomedich-872	47	18	complex	complex	NOUN
biomedich-872	47	19	,	,	PUNCT
biomedich-872	47	20	the	the	DET
biomedich-872	47	21	study	study	NOUN
biomedich-872	47	22	seeks	seek	VERB
biomedich-872	47	23	to	to	PART
biomedich-872	47	24	identify	identify	VERB
biomedich-872	47	25	candidate	candidate	NOUN
biomedich-872	47	26	molecules	molecule	NOUN
biomedich-872	47	27	with	with	ADP
biomedich-872	47	28	high	high	ADJ
biomedich-872	47	29	binding	bind	VERB
biomedich-872	47	30	affinity	affinity	NOUN
biomedich-872	47	31	that	that	PRON
biomedich-872	47	32	may	may	AUX
biomedich-872	47	33	serve	serve	VERB
biomedich-872	47	34	as	as	ADP
biomedich-872	47	35	novel	novel	ADJ
biomedich-872	47	36	therapeutic	therapeutic	ADJ
biomedich-872	47	37	agents	agent	NOUN
biomedich-872	47	38	.	.	PUNCT
biomedich-872	48	1	the	the	DET
biomedich-872	48	2	use	use	NOUN
biomedich-872	48	3	of	of	ADP
biomedich-872	48	4	molecular	molecular	ADJ
biomedich-872	48	5	docking	docking	NOUN
biomedich-872	48	6	offers	offer	VERB
biomedich-872	48	7	a	a	DET
biomedich-872	48	8	cost	cost	NOUN
biomedich-872	48	9	-	-	PUNCT
biomedich-872	48	10	effective	effective	ADJ
biomedich-872	48	11	,	,	PUNCT
biomedich-872	48	12	predictive	predictive	ADJ
biomedich-872	48	13	method	method	NOUN
biomedich-872	48	14	for	for	ADP
biomedich-872	48	15	assessing	assess	VERB
biomedich-872	48	16	the	the	DET
biomedich-872	48	17	pharmacological	pharmacological	ADJ
biomedich-872	48	18	potential	potential	NOUN
biomedich-872	48	19	of	of	ADP
biomedich-872	48	20	natural	natural	ADJ
biomedich-872	48	21	compounds	compound	NOUN
biomedich-872	48	22	prior	prior	ADV
biomedich-872	48	23	to	to	ADP
biomedich-872	48	24	in	in	ADP
biomedich-872	48	25	vitro	vitro	X
biomedich-872	48	26	or	or	CCONJ
biomedich-872	48	27	in	in	ADP
biomedich-872	48	28	vivo	vivo	ADJ
biomedich-872	48	29	validation	validation	NOUN
biomedich-872	48	30	.	.	PUNCT
biomedich-872	49	1	ultimately	ultimately	ADV
biomedich-872	49	2	,	,	PUNCT
biomedich-872	49	3	this	this	DET
biomedich-872	49	4	research	research	NOUN
biomedich-872	49	5	supports	support	VERB
biomedich-872	49	6	the	the	DET
biomedich-872	49	7	advancement	advancement	NOUN
biomedich-872	49	8	of	of	ADP
biomedich-872	49	9	plant	plant	NOUN
biomedich-872	49	10	-	-	PUNCT
biomedich-872	49	11	based	base	VERB
biomedich-872	49	12	antifibrotic	antifibrotic	ADJ
biomedich-872	49	13	therapies	therapy	NOUN
biomedich-872	49	14	that	that	PRON
biomedich-872	49	15	are	be	AUX
biomedich-872	49	16	safer	safe	ADJ
biomedich-872	49	17	and	and	CCONJ
biomedich-872	49	18	potentially	potentially	ADV
biomedich-872	49	19	more	more	ADV
biomedich-872	49	20	effective	effective	ADJ
biomedich-872	49	21	than	than	ADP
biomedich-872	49	22	current	current	ADJ
biomedich-872	49	23	pharmacological	pharmacological	ADJ
biomedich-872	49	24	options	option	NOUN
biomedich-872	49	25	.	.	PUNCT
biomedich-872	50	1	it	it	PRON
biomedich-872	50	2	also	also	ADV
biomedich-872	50	3	contributes	contribute	VERB
biomedich-872	50	4	to	to	ADP
biomedich-872	50	5	the	the	DET
biomedich-872	50	6	broader	broad	ADJ
biomedich-872	50	7	scientific	scientific	ADJ
biomedich-872	50	8	understanding	understanding	NOUN
biomedich-872	50	9	of	of	ADP
biomedich-872	50	10	how	how	SCONJ
biomedich-872	50	11	natural	natural	ADJ
biomedich-872	50	12	compounds	compound	NOUN
biomedich-872	50	13	can	can	AUX
biomedich-872	50	14	be	be	AUX
biomedich-872	50	15	leveraged	leverage	VERB
biomedich-872	50	16	to	to	PART
biomedich-872	50	17	modulate	modulate	VERB
biomedich-872	50	18	key	key	ADJ
biomedich-872	50	19	fibrotic	fibrotic	ADJ
biomedich-872	50	20	signalling	signal	VERB
biomedich-872	50	21	pathways	pathway	NOUN
biomedich-872	50	22	.	.	PUNCT
biomedich-872	51	1	materials	material	NOUN
biomedich-872	51	2	and	and	CCONJ
biomedich-872	51	3	methods	method	NOUN
biomedich-872	51	4	prediction	prediction	NOUN
biomedich-872	51	5	of	of	ADP
biomedich-872	51	6	antifibrotic	antifibrotic	ADJ
biomedich-872	51	7	activity	activity	NOUN
biomedich-872	51	8	the	the	DET
biomedich-872	51	9	potential	potential	ADJ
biomedich-872	51	10	antifibrotic	antifibrotic	ADJ
biomedich-872	51	11	activity	activity	NOUN
biomedich-872	51	12	of	of	ADP
biomedich-872	51	13	physalis	physali	NOUN
biomedich-872	51	14	angulata	angulata	VERB
biomedich-872	51	15	active	active	ADJ
biomedich-872	51	16	compounds	compound	NOUN
biomedich-872	51	17	was	be	AUX
biomedich-872	51	18	assessed	assess	VERB
biomedich-872	51	19	using	use	VERB
biomedich-872	51	20	the	the	DET
biomedich-872	51	21	ddi	ddi	ADJ
biomedich-872	51	22	-	-	PUNCT
biomedich-872	51	23	pred	pre	VERB
biomedich-872	51	24	module	module	NOUN
biomedich-872	51	25	of	of	ADP
biomedich-872	51	26	the	the	DET
biomedich-872	51	27	way2drug	way2drug	PROPN
biomedich-872	51	28	software	software	NOUN
biomedich-872	51	29	.	.	PUNCT
biomedich-872	52	1	this	this	DET
biomedich-872	52	2	approach	approach	NOUN
biomedich-872	52	3	is	be	AUX
biomedich-872	52	4	grounded	ground	VERB
biomedich-872	52	5	in	in	ADP
biomedich-872	52	6	the	the	DET
biomedich-872	52	7	prediction	prediction	NOUN
biomedich-872	52	8	of	of	ADP
biomedich-872	52	9	activity	activity	NOUN
biomedich-872	52	10	spectra	spectra	NOUN
biomedich-872	52	11	for	for	ADP
biomedich-872	52	12	substances	substance	NOUN
biomedich-872	52	13	(	(	PUNCT
biomedich-872	52	14	pass	pass	NOUN
biomedich-872	52	15	)	)	PUNCT
biomedich-872	52	16	technology	technology	NOUN
biomedich-872	52	17	,	,	PUNCT
biomedich-872	52	18	which	which	PRON
biomedich-872	52	19	enables	enable	VERB
biomedich-872	52	20	prediction	prediction	NOUN
biomedich-872	52	21	of	of	ADP
biomedich-872	52	22	molecular	molecular	ADJ
biomedich-872	52	23	interactions	interaction	NOUN
biomedich-872	52	24	based	base	VERB
biomedich-872	52	25	on	on	ADP
biomedich-872	52	26	the	the	DET
biomedich-872	52	27	structural	structural	ADJ
biomedich-872	52	28	and	and	CCONJ
biomedich-872	52	29	biological	biological	ADJ
biomedich-872	52	30	activity	activity	NOUN
biomedich-872	52	31	relationships	relationship	NOUN
biomedich-872	52	32	of	of	ADP
biomedich-872	52	33	compounds	compound	NOUN
biomedich-872	52	34	.	.	PUNCT
biomedich-872	53	1	this	this	DET
biomedich-872	53	2	method	method	NOUN
biomedich-872	53	3	facilitates	facilitate	VERB
biomedich-872	53	4	the	the	DET
biomedich-872	53	5	evaluation	evaluation	NOUN
biomedich-872	53	6	of	of	ADP
biomedich-872	53	7	the	the	DET
biomedich-872	53	8	likelihood	likelihood	NOUN
biomedich-872	53	9	that	that	SCONJ
biomedich-872	53	10	active	active	ADJ
biomedich-872	53	11	compounds	compound	NOUN
biomedich-872	53	12	interact	interact	VERB
biomedich-872	53	13	with	with	ADP
biomedich-872	53	14	molecular	molecular	ADJ
biomedich-872	53	15	targets	target	NOUN
biomedich-872	53	16	involved	involve	VERB
biomedich-872	53	17	in	in	ADP
biomedich-872	53	18	pulmonary	pulmonary	ADJ
biomedich-872	53	19	fibrosis	fibrosis	NOUN
biomedich-872	53	20	,	,	PUNCT
biomedich-872	53	21	providing	provide	VERB
biomedich-872	53	22	an	an	DET
biomedich-872	53	23	initial	initial	ADJ
biomedich-872	53	24	indication	indication	NOUN
biomedich-872	53	25	of	of	ADP
biomedich-872	53	26	their	their	PRON
biomedich-872	53	27	antifibrotic	antifibrotic	ADJ
biomedich-872	53	28	potential	potential	NOUN
biomedich-872	53	29	(	(	PUNCT
biomedich-872	53	30	ananthathandavan	ananthathandavan	NOUN
biomedich-872	53	31	&	&	CCONJ
biomedich-872	53	32	narayanasamy	narayanasamy	NOUN
biomedich-872	53	33	,	,	PUNCT
biomedich-872	53	34	2024	2024	NUM
biomedich-872	53	35	)	)	PUNCT
biomedich-872	53	36	.	.	PUNCT
biomedich-872	54	1	receptor	receptor	NOUN
biomedich-872	54	2	and	and	CCONJ
biomedich-872	54	3	ligand	ligand	ADJ
biomedich-872	54	4	preparation	preparation	NOUN
biomedich-872	54	5	this	this	DET
biomedich-872	54	6	study	study	NOUN
biomedich-872	54	7	utilized	utilize	VERB
biomedich-872	54	8	the	the	DET
biomedich-872	54	9	pi3k	pi3k	PROPN
biomedich-872	54	10	/	/	SYM
biomedich-872	54	11	akt	akt	PROPN
biomedich-872	54	12	protein	protein	NOUN
biomedich-872	54	13	with	with	ADP
biomedich-872	54	14	pdb	pdb	PROPN
biomedich-872	55	1	i	i	PROPN
biomedich-872	55	2	d	d	PROPN
biomedich-872	55	3	:	:	PUNCT
biomedich-872	56	1	2uzt	2uzt	NUM
biomedich-872	56	2	,	,	PUNCT
biomedich-872	56	3	obtained	obtain	VERB
biomedich-872	56	4	from	from	ADP
biomedich-872	56	5	the	the	DET
biomedich-872	56	6	rcsb	rcsb	ADJ
biomedich-872	56	7	protein	protein	NOUN
biomedich-872	56	8	data	datum	NOUN
biomedich-872	56	9	bank	bank	NOUN
biomedich-872	56	10	(	(	PUNCT
biomedich-872	56	11	https://www.rcsb.org/	https://www.rcsb.org/	ADJ
biomedich-872	56	12	)	)	PUNCT
biomedich-872	56	13	.	.	PUNCT
biomedich-872	57	1	this	this	DET
biomedich-872	57	2	protein	protein	NOUN
biomedich-872	57	3	was	be	AUX
biomedich-872	57	4	selected	select	VERB
biomedich-872	57	5	based	base	VERB
biomedich-872	57	6	on	on	ADP
biomedich-872	57	7	previous	previous	ADJ
biomedich-872	57	8	research	research	NOUN
biomedich-872	57	9	where	where	SCONJ
biomedich-872	57	10	it	it	PRON
biomedich-872	57	11	was	be	AUX
biomedich-872	57	12	employed	employ	VERB
biomedich-872	57	13	to	to	PART
biomedich-872	57	14	predict	predict	VERB
biomedich-872	57	15	the	the	DET
biomedich-872	57	16	anti	anti	ADJ
biomedich-872	57	17	-	-	ADJ
biomedich-872	57	18	apoptotic	apoptotic	ADJ
biomedich-872	57	19	potential	potential	NOUN
biomedich-872	57	20	of	of	ADP
biomedich-872	57	21	cinnamaldehyde	cinnamaldehyde	NOUN
biomedich-872	57	22	(	(	PUNCT
biomedich-872	57	23	fukata	fukata	PROPN
biomedich-872	57	24	et	et	PROPN
biomedich-872	57	25	al	al	PROPN
biomedich-872	57	26	.	.	PROPN
biomedich-872	57	27	,	,	PUNCT
biomedich-872	57	28	2025	2025	NUM
biomedich-872	57	29	)	)	PUNCT
biomedich-872	57	30	.	.	PUNCT
biomedich-872	58	1	the	the	DET
biomedich-872	58	2	retrieved	retrieve	VERB
biomedich-872	58	3	protein	protein	NOUN
biomedich-872	58	4	structure	structure	NOUN
biomedich-872	58	5	was	be	AUX
biomedich-872	58	6	subsequently	subsequently	ADV
biomedich-872	58	7	repaired	repair	VERB
biomedich-872	58	8	to	to	PART
biomedich-872	58	9	isolate	isolate	VERB
biomedich-872	58	10	the	the	DET
biomedich-872	58	11	protein	protein	NOUN
biomedich-872	58	12	chains	chain	NOUN
biomedich-872	58	13	and	and	CCONJ
biomedich-872	58	14	native	native	ADJ
biomedich-872	58	15	ligands	ligand	NOUN
biomedich-872	58	16	essential	essential	ADJ
biomedich-872	58	17	for	for	ADP
biomedich-872	58	18	validation	validation	NOUN
biomedich-872	58	19	purposes	purpose	NOUN
biomedich-872	58	20	(	(	PUNCT
biomedich-872	58	21	utami	utami	NOUN
biomedich-872	58	22	et	et	PROPN
biomedich-872	58	23	al	al	PROPN
biomedich-872	58	24	.	.	PROPN
biomedich-872	58	25	,	,	PUNCT
biomedich-872	58	26	2025	2025	NUM
biomedich-872	58	27	)	)	PUNCT
biomedich-872	58	28	.	.	PUNCT
biomedich-872	59	1	this	this	DET
biomedich-872	59	2	step	step	NOUN
biomedich-872	59	3	was	be	AUX
biomedich-872	59	4	carried	carry	VERB
biomedich-872	59	5	out	out	ADP
biomedich-872	59	6	using	use	VERB
biomedich-872	59	7	biovia	biovia	PROPN
biomedich-872	59	8	discovery	discovery	PROPN
biomedich-872	59	9	studio	studio	NOUN
biomedich-872	59	10	2024	2024	NUM
biomedich-872	59	11	to	to	PART
biomedich-872	59	12	determine	determine	VERB
biomedich-872	59	13	the	the	DET
biomedich-872	59	14	specific	specific	ADJ
biomedich-872	59	15	protein	protein	NOUN
biomedich-872	59	16	sequences	sequence	NOUN
biomedich-872	59	17	accurately	accurately	ADV
biomedich-872	59	18	.	.	PUNCT
biomedich-872	60	1	the	the	DET
biomedich-872	60	2	active	active	ADJ
biomedich-872	60	3	compounds	compound	NOUN
biomedich-872	60	4	from	from	ADP
biomedich-872	60	5	physalis	physalis	NOUN
biomedich-872	60	6	angulata	angulata	NOUN
biomedich-872	60	7	served	serve	VERB
biomedich-872	60	8	as	as	ADP
biomedich-872	60	9	test	test	NOUN
biomedich-872	60	10	ligands	ligand	NOUN
biomedich-872	60	11	in	in	ADP
biomedich-872	60	12	this	this	DET
biomedich-872	60	13	study	study	NOUN
biomedich-872	60	14	,	,	PUNCT
biomedich-872	60	15	with	with	ADP
biomedich-872	60	16	their	their	PRON
biomedich-872	60	17	chemical	chemical	NOUN
biomedich-872	60	18	structures	structure	NOUN
biomedich-872	60	19	retrieved	retrieve	VERB
biomedich-872	60	20	from	from	ADP
biomedich-872	60	21	the	the	DET
biomedich-872	60	22	pubchem	pubchem	NOUN
biomedich-872	60	23	database	database	NOUN
biomedich-872	60	24	(	(	PUNCT
biomedich-872	60	25	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
biomedich-872	60	26	)	)	PUNCT
biomedich-872	60	27	.	.	PUNCT
biomedich-872	61	1	a	a	DET
biomedich-872	61	2	total	total	NOUN
biomedich-872	61	3	of	of	ADP
biomedich-872	61	4	ten	ten	NUM
biomedich-872	61	5	compounds	compound	NOUN
biomedich-872	61	6	were	be	AUX
biomedich-872	61	7	analyzed	analyze	VERB
biomedich-872	61	8	:	:	PUNCT
biomedich-872	61	9	rhoifolin	rhoifolin	NOUN
biomedich-872	61	10	(	(	PUNCT
biomedich-872	61	11	cid	cid	PROPN
biomedich-872	61	12	5282150	5282150	NUM
biomedich-872	61	13	)	)	PUNCT
biomedich-872	61	14	,	,	PUNCT
biomedich-872	61	15	tangeretin	tangeretin	X
biomedich-872	61	16	(	(	PUNCT
biomedich-872	61	17	cid	cid	NOUN
biomedich-872	61	18	68077	68077	NUM
biomedich-872	61	19	)	)	PUNCT
biomedich-872	61	20	,	,	PUNCT
biomedich-872	61	21	eriodictyol	eriodictyol	PROPN
biomedich-872	61	22	(	(	PUNCT
biomedich-872	61	23	cid	cid	PROPN
biomedich-872	61	24	440735	440735	NUM
biomedich-872	61	25	)	)	PUNCT
biomedich-872	61	26	,	,	PUNCT
biomedich-872	61	27	catechin	catechin	NOUN
biomedich-872	61	28	(	(	PUNCT
biomedich-872	61	29	cid	cid	PROPN
biomedich-872	61	30	9064	9064	NUM
biomedich-872	61	31	)	)	PUNCT
biomedich-872	61	32	,	,	PUNCT
biomedich-872	61	33	naringin	naringin	NOUN
biomedich-872	61	34	(	(	PUNCT
biomedich-872	61	35	cid	cid	NOUN
biomedich-872	61	36	442428	442428	NUM
biomedich-872	61	37	)	)	PUNCT
biomedich-872	61	38	,	,	PUNCT
biomedich-872	61	39	myricetrin	myricetrin	NOUN
biomedich-872	61	40	(	(	PUNCT
biomedich-872	61	41	cid	cid	NOUN
biomedich-872	61	42	5281673	5281673	NUM
biomedich-872	61	43	)	)	PUNCT
biomedich-872	61	44	,	,	PUNCT
biomedich-872	61	45	kaempferol	kaempferol	NOUN
biomedich-872	61	46	(	(	PUNCT
biomedich-872	61	47	cid	cid	PROPN
biomedich-872	61	48	5280863	5280863	NUM
biomedich-872	61	49	)	)	PUNCT
biomedich-872	61	50	,	,	PUNCT
biomedich-872	61	51	hesperidin	hesperidin	PROPN
biomedich-872	61	52	(	(	PUNCT
biomedich-872	61	53	cid	cid	PROPN
biomedich-872	61	54	10621	10621	NUM
biomedich-872	61	55	)	)	PUNCT
biomedich-872	61	56	,	,	PUNCT
biomedich-872	61	57	epigallocatechin	epigallocatechin	NOUN
biomedich-872	61	58	(	(	PUNCT
biomedich-872	61	59	cid	cid	PROPN
biomedich-872	61	60	72277	72277	NUM
biomedich-872	61	61	)	)	PUNCT
biomedich-872	61	62	,	,	PUNCT
biomedich-872	61	63	and	and	CCONJ
biomedich-872	61	64	apigenin	apigenin	PROPN
biomedich-872	61	65	(	(	PUNCT
biomedich-872	61	66	cid	cid	PROPN
biomedich-872	61	67	5280443	5280443	NUM
biomedich-872	61	68	)	)	PUNCT
biomedich-872	61	69	(	(	PUNCT
biomedich-872	61	70	ekeke	ekeke	PROPN
biomedich-872	61	71	et	et	PROPN
biomedich-872	61	72	al	al	PROPN
biomedich-872	61	73	.	.	PROPN
biomedich-872	61	74	,	,	PUNCT
biomedich-872	61	75	2019	2019	NUM
biomedich-872	61	76	;	;	PUNCT
biomedich-872	61	77	nguyen	nguyen	NOUN
biomedich-872	61	78	et	et	PROPN
biomedich-872	61	79	al	al	PROPN
biomedich-872	61	80	.	.	PROPN
biomedich-872	61	81	,	,	PUNCT
biomedich-872	61	82	2021	2021	NUM
biomedich-872	61	83	)	)	PUNCT
biomedich-872	61	84	.	.	PUNCT
biomedich-872	62	1	nintedanib	nintedanib	PROPN
biomedich-872	62	2	was	be	AUX
biomedich-872	62	3	included	include	VERB
biomedich-872	62	4	as	as	ADP
biomedich-872	62	5	a	a	DET
biomedich-872	62	6	reference	reference	NOUN
biomedich-872	62	7	standard	standard	NOUN
biomedich-872	62	8	due	due	ADP
biomedich-872	62	9	to	to	ADP
biomedich-872	62	10	its	its	PRON
biomedich-872	62	11	well	well	ADV
biomedich-872	62	12	documented	document	VERB
biomedich-872	62	13	clinical	clinical	ADJ
biomedich-872	62	14	efficacy	efficacy	NOUN
biomedich-872	62	15	in	in	ADP
biomedich-872	62	16	slowing	slow	VERB
biomedich-872	62	17	disease	disease	NOUN
biomedich-872	62	18	progression	progression	NOUN
biomedich-872	62	19	by	by	ADP
biomedich-872	62	20	reducing	reduce	VERB
biomedich-872	62	21	pulmonary	pulmonary	ADJ
biomedich-872	62	22	function	function	NOUN
biomedich-872	62	23	decline	decline	NOUN
biomedich-872	62	24	(	(	PUNCT
biomedich-872	62	25	kreuter	kreuter	NOUN
biomedich-872	62	26	et	et	PROPN
biomedich-872	62	27	al	al	PROPN
biomedich-872	62	28	.	.	PROPN
biomedich-872	62	29	,	,	PUNCT
biomedich-872	62	30	2021	2021	NUM
biomedich-872	62	31	)	)	PUNCT
biomedich-872	62	32	.	.	PUNCT
biomedich-872	63	1	molecular	molecular	ADJ
biomedich-872	63	2	docking	docking	NOUN
biomedich-872	63	3	simulation	simulation	NOUN
biomedich-872	63	4	a	a	DET
biomedich-872	63	5	crucial	crucial	ADJ
biomedich-872	63	6	step	step	NOUN
biomedich-872	63	7	in	in	ADP
biomedich-872	63	8	this	this	DET
biomedich-872	63	9	study	study	NOUN
biomedich-872	63	10	involved	involve	VERB
biomedich-872	63	11	validating	validate	VERB
biomedich-872	63	12	the	the	DET
biomedich-872	63	13	docking	docking	NOUN
biomedich-872	63	14	methodology	methodology	NOUN
biomedich-872	63	15	through	through	ADP
biomedich-872	63	16	a	a	DET
biomedich-872	63	17	redocking	redocke	VERB
biomedich-872	63	18	procedure	procedure	NOUN
biomedich-872	63	19	to	to	PART
biomedich-872	63	20	confirm	confirm	VERB
biomedich-872	63	21	its	its	PRON
biomedich-872	63	22	accuracy	accuracy	NOUN
biomedich-872	63	23	.	.	PUNCT
biomedich-872	64	1	redocking	redocking	NOUN
biomedich-872	64	2	evaluates	evaluate	NOUN
biomedich-872	64	3	whether	whether	SCONJ
biomedich-872	64	4	the	the	DET
biomedich-872	64	5	docking	docking	NOUN
biomedich-872	64	6	protocol	protocol	NOUN
biomedich-872	64	7	can	can	AUX
biomedich-872	64	8	accurately	accurately	ADV
biomedich-872	64	9	reproduce	reproduce	VERB
biomedich-872	64	10	the	the	DET
biomedich-872	64	11	native	native	ADJ
biomedich-872	64	12	ligand	ligand	NOUN
biomedich-872	64	13	’s	’s	PART
biomedich-872	64	14	binding	bind	VERB
biomedich-872	64	15	pose	pose	NOUN
biomedich-872	64	16	within	within	ADP
biomedich-872	64	17	the	the	DET
biomedich-872	64	18	protein	protein	NOUN
biomedich-872	64	19	-	-	PUNCT
biomedich-872	64	20	ligand	ligand	NOUN
biomedich-872	64	21	complex	complex	NOUN
biomedich-872	64	22	.	.	PUNCT
biomedich-872	65	1	this	this	DET
biomedich-872	65	2	assessment	assessment	NOUN
biomedich-872	65	3	is	be	AUX
biomedich-872	65	4	quantified	quantify	VERB
biomedich-872	65	5	by	by	ADP
biomedich-872	65	6	calculating	calculate	VERB
biomedich-872	65	7	the	the	DET
biomedich-872	65	8	root	root	NOUN
biomedich-872	65	9	mean	mean	ADJ
biomedich-872	65	10	square	square	ADJ
biomedich-872	65	11	deviation	deviation	NOUN
biomedich-872	65	12	(	(	PUNCT
biomedich-872	65	13	rmsd	rmsd	NOUN
biomedich-872	65	14	)	)	PUNCT
biomedich-872	65	15	between	between	ADP
biomedich-872	65	16	the	the	DET
biomedich-872	65	17	docked	docked	ADJ
biomedich-872	65	18	and	and	CCONJ
biomedich-872	65	19	original	original	ADJ
biomedich-872	65	20	ligand	ligand	NOUN
biomedich-872	65	21	positions	position	NOUN
biomedich-872	65	22	,	,	PUNCT
biomedich-872	65	23	with	with	ADP
biomedich-872	65	24	values	value	NOUN
biomedich-872	65	25	below	below	ADP
biomedich-872	65	26	2	2	NUM
biomedich-872	65	27	å	å	NOUN
biomedich-872	65	28	considered	consider	VERB
biomedich-872	65	29	acceptable	acceptable	ADJ
biomedich-872	65	30	.	.	PUNCT
biomedich-872	66	1	lower	low	ADJ
biomedich-872	66	2	rmsd	rmsd	PROPN
biomedich-872	66	3	values	value	NOUN
biomedich-872	66	4	correspond	correspond	VERB
biomedich-872	66	5	to	to	ADP
biomedich-872	66	6	higher	high	ADJ
biomedich-872	66	7	docking	docking	NOUN
biomedich-872	66	8	precision	precision	NOUN
biomedich-872	66	9	.	.	PUNCT
biomedich-872	67	1	besides	besides	SCONJ
biomedich-872	67	2	validation	validation	NOUN
biomedich-872	67	3	,	,	PUNCT
biomedich-872	67	4	redocking	redocke	VERB
biomedich-872	67	5	aids	aid	NOUN
biomedich-872	67	6	in	in	ADP
biomedich-872	67	7	defining	define	VERB
biomedich-872	67	8	the	the	DET
biomedich-872	67	9	grid	grid	NOUN
biomedich-872	67	10	box	box	PROPN
biomedich-872	67	11	’s	’s	PART
biomedich-872	67	12	center	center	PROPN
biomedich-872	67	13	coordinates	coordinate	NOUN
biomedich-872	67	14	(	(	PUNCT
biomedich-872	67	15	x	x	X
biomedich-872	67	16	,	,	PUNCT
biomedich-872	67	17	y	y	PROPN
biomedich-872	67	18	,	,	PUNCT
biomedich-872	67	19	z	z	NOUN
biomedich-872	67	20	)	)	PUNCT
biomedich-872	67	21	and	and	CCONJ
biomedich-872	67	22	dimensions	dimension	NOUN
biomedich-872	67	23	for	for	ADP
biomedich-872	67	24	subsequent	subsequent	ADJ
biomedich-872	67	25	specific	specific	ADJ
biomedich-872	67	26	docking	docking	NOUN
biomedich-872	67	27	runs	run	NOUN
biomedich-872	67	28	,	,	PUNCT
biomedich-872	67	29	referencing	reference	VERB
biomedich-872	67	30	the	the	DET
biomedich-872	67	31	native	native	ADJ
biomedich-872	67	32	ligand	ligand	NOUN
biomedich-872	67	33	’s	’s	PART
biomedich-872	67	34	position	position	NOUN
biomedich-872	67	35	in	in	ADP
biomedich-872	67	36	the	the	DET
biomedich-872	67	37	crystal	crystal	NOUN
biomedich-872	67	38	structure	structure	NOUN
biomedich-872	67	39	(	(	PUNCT
biomedich-872	67	40	farid	farid	PROPN
biomedich-872	67	41	et	et	PROPN
biomedich-872	67	42	al	al	PROPN
biomedich-872	67	43	.	.	PROPN
biomedich-872	67	44	,	,	PUNCT
biomedich-872	67	45	2025	2025	NUM
biomedich-872	67	46	)	)	PUNCT
biomedich-872	67	47	.	.	PUNCT
biomedich-872	68	1	docking	docking	NOUN
biomedich-872	68	2	simulations	simulation	NOUN
biomedich-872	68	3	were	be	AUX
biomedich-872	68	4	performed	perform	VERB
biomedich-872	68	5	using	use	VERB
biomedich-872	68	6	autodock	autodock	NOUN
biomedich-872	68	7	https://www.rcsb.org/	https://www.rcsb.org/	X
biomedich-872	68	8	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
biomedich-872	68	9	farid	farid	PROPN
biomedich-872	68	10	et	et	PROPN
biomedich-872	68	11	al	al	PROPN
biomedich-872	68	12	.	.	PROPN
biomedich-872	68	13	–	–	PUNCT
biomedich-872	68	14	predicting	predict	VERB
biomedich-872	68	15	the	the	DET
biomedich-872	68	16	anti	anti	ADJ
biomedich-872	68	17	-	-	ADJ
biomedich-872	68	18	pulmonary	pulmonary	ADJ
biomedich-872	68	19	fibrosis	fibrosis	NOUN
biomedich-872	68	20	potential	potential	NOUN
biomedich-872	68	21	…	…	PUNCT
biomedich-872	68	22	819	819	NUM
biomedich-872	68	23	vina	vina	NOUN
biomedich-872	68	24	integrated	integrate	VERB
biomedich-872	68	25	within	within	ADP
biomedich-872	68	26	pyrx	pyrx	NOUN
biomedich-872	68	27	software	software	NOUN
biomedich-872	68	28	.	.	PUNCT
biomedich-872	69	1	prior	prior	ADV
biomedich-872	69	2	to	to	ADP
biomedich-872	69	3	docking	docking	NOUN
biomedich-872	69	4	,	,	PUNCT
biomedich-872	69	5	ligand	ligand	ADJ
biomedich-872	69	6	and	and	CCONJ
biomedich-872	69	7	receptor	receptor	NOUN
biomedich-872	69	8	files	file	NOUN
biomedich-872	69	9	were	be	AUX
biomedich-872	69	10	converted	convert	VERB
biomedich-872	69	11	to	to	ADP
biomedich-872	69	12	the	the	DET
biomedich-872	69	13	pdbqt	pdbqt	ADJ
biomedich-872	69	14	format	format	NOUN
biomedich-872	69	15	using	use	VERB
biomedich-872	69	16	open	open	ADJ
biomedich-872	69	17	babel	babel	NOUN
biomedich-872	69	18	,	,	PUNCT
biomedich-872	69	19	which	which	PRON
biomedich-872	69	20	also	also	ADV
biomedich-872	69	21	facilitated	facilitate	VERB
biomedich-872	69	22	energy	energy	NOUN
biomedich-872	69	23	minimization	minimization	NOUN
biomedich-872	69	24	to	to	PART
biomedich-872	69	25	ensure	ensure	VERB
biomedich-872	69	26	that	that	SCONJ
biomedich-872	69	27	both	both	DET
biomedich-872	69	28	ligand	ligand	ADJ
biomedich-872	69	29	and	and	CCONJ
biomedich-872	69	30	receptor	receptor	NOUN
biomedich-872	69	31	conformations	conformation	NOUN
biomedich-872	69	32	were	be	AUX
biomedich-872	69	33	energetically	energetically	ADV
biomedich-872	69	34	favorable	favorable	ADJ
biomedich-872	69	35	.	.	PUNCT
biomedich-872	70	1	docking	docking	NOUN
biomedich-872	70	2	results	result	NOUN
biomedich-872	70	3	were	be	AUX
biomedich-872	70	4	evaluated	evaluate	VERB
biomedich-872	70	5	based	base	VERB
biomedich-872	70	6	on	on	ADP
biomedich-872	70	7	binding	bind	VERB
biomedich-872	70	8	affinity	affinity	NOUN
biomedich-872	70	9	values	value	NOUN
biomedich-872	70	10	,	,	PUNCT
biomedich-872	70	11	with	with	ADP
biomedich-872	70	12	lower	low	ADJ
biomedich-872	70	13	affinities	affinity	NOUN
biomedich-872	70	14	indicating	indicate	VERB
biomedich-872	70	15	stronger	strong	ADJ
biomedich-872	70	16	ligand	ligand	NOUN
biomedich-872	70	17	-	-	PUNCT
biomedich-872	70	18	protein	protein	NOUN
biomedich-872	70	19	interactions	interaction	NOUN
biomedich-872	70	20	and	and	CCONJ
biomedich-872	70	21	potential	potential	ADJ
biomedich-872	70	22	biological	biological	ADJ
biomedich-872	70	23	activity	activity	NOUN
biomedich-872	70	24	(	(	PUNCT
biomedich-872	70	25	farid	farid	PROPN
biomedich-872	70	26	et	et	PROPN
biomedich-872	70	27	al	al	PROPN
biomedich-872	70	28	.	.	PROPN
biomedich-872	70	29	,	,	PUNCT
biomedich-872	70	30	2025	2025	NUM
biomedich-872	70	31	)	)	PUNCT
biomedich-872	70	32	.	.	PUNCT
biomedich-872	71	1	visualization	visualization	NOUN
biomedich-872	71	2	of	of	ADP
biomedich-872	71	3	docking	docking	NOUN
biomedich-872	71	4	results	result	NOUN
biomedich-872	71	5	redocking	redocke	VERB
biomedich-872	71	6	outcomes	outcome	NOUN
biomedich-872	71	7	were	be	AUX
biomedich-872	71	8	analyzed	analyze	VERB
biomedich-872	71	9	by	by	ADP
biomedich-872	71	10	calculating	calculate	VERB
biomedich-872	71	11	rmsd	rmsd	NOUN
biomedich-872	71	12	values	value	NOUN
biomedich-872	71	13	to	to	PART
biomedich-872	71	14	assess	assess	VERB
biomedich-872	71	15	the	the	DET
biomedich-872	71	16	congruence	congruence	NOUN
biomedich-872	71	17	between	between	ADP
biomedich-872	71	18	docked	docked	ADJ
biomedich-872	71	19	ligand	ligand	NOUN
biomedich-872	71	20	positions	position	NOUN
biomedich-872	71	21	and	and	CCONJ
biomedich-872	71	22	their	their	PRON
biomedich-872	71	23	native	native	ADJ
biomedich-872	71	24	conformations	conformation	NOUN
biomedich-872	71	25	.	.	PUNCT
biomedich-872	72	1	additionally	additionally	ADV
biomedich-872	72	2	,	,	PUNCT
biomedich-872	72	3	three	three	NUM
biomedich-872	72	4	dimensional	dimensional	ADJ
biomedich-872	72	5	overlap	overlap	NOUN
biomedich-872	72	6	visualization	visualization	NOUN
biomedich-872	72	7	of	of	ADP
biomedich-872	72	8	ligands	ligand	NOUN
biomedich-872	72	9	before	before	ADV
biomedich-872	72	10	and	and	CCONJ
biomedich-872	72	11	after	after	ADP
biomedich-872	72	12	docking	docking	NOUN
biomedich-872	72	13	was	be	AUX
biomedich-872	72	14	performed	perform	VERB
biomedich-872	72	15	using	use	VERB
biomedich-872	72	16	pymol	pymol	PROPN
biomedich-872	72	17	to	to	PART
biomedich-872	72	18	observe	observe	VERB
biomedich-872	72	19	positional	positional	ADJ
biomedich-872	72	20	deviations	deviation	NOUN
biomedich-872	72	21	(	(	PUNCT
biomedich-872	72	22	farid	farid	PROPN
biomedich-872	72	23	et	et	PROPN
biomedich-872	72	24	al	al	PROPN
biomedich-872	72	25	.	.	PROPN
biomedich-872	72	26	,	,	PUNCT
biomedich-872	72	27	2025	2025	NUM
biomedich-872	72	28	)	)	PUNCT
biomedich-872	72	29	.	.	PUNCT
biomedich-872	73	1	further	further	ADJ
biomedich-872	73	2	interaction	interaction	NOUN
biomedich-872	73	3	analysis	analysis	NOUN
biomedich-872	73	4	between	between	ADP
biomedich-872	73	5	ligands	ligand	NOUN
biomedich-872	73	6	and	and	CCONJ
biomedich-872	73	7	amino	amino	NOUN
biomedich-872	73	8	acid	acid	NOUN
biomedich-872	73	9	residues	residue	NOUN
biomedich-872	73	10	within	within	ADP
biomedich-872	73	11	the	the	DET
biomedich-872	73	12	receptor	receptor	NOUN
biomedich-872	73	13	binding	bind	VERB
biomedich-872	73	14	site	site	NOUN
biomedich-872	73	15	was	be	AUX
biomedich-872	73	16	conducted	conduct	VERB
biomedich-872	73	17	using	use	VERB
biomedich-872	73	18	biovia	biovia	NOUN
biomedich-872	73	19	software	software	NOUN
biomedich-872	73	20	,	,	PUNCT
biomedich-872	73	21	enabling	enable	VERB
biomedich-872	73	22	detailed	detailed	ADJ
biomedich-872	73	23	characterization	characterization	NOUN
biomedich-872	73	24	of	of	ADP
biomedich-872	73	25	the	the	DET
biomedich-872	73	26	types	type	NOUN
biomedich-872	73	27	and	and	CCONJ
biomedich-872	73	28	strengths	strength	NOUN
biomedich-872	73	29	of	of	ADP
biomedich-872	73	30	molecular	molecular	ADJ
biomedich-872	73	31	interactions	interaction	NOUN
biomedich-872	73	32	formed	form	VERB
biomedich-872	73	33	(	(	PUNCT
biomedich-872	73	34	farid	farid	PROPN
biomedich-872	73	35	et	et	PROPN
biomedich-872	73	36	al	al	PROPN
biomedich-872	73	37	.	.	PROPN
biomedich-872	73	38	,	,	PUNCT
biomedich-872	73	39	2025	2025	NUM
biomedich-872	73	40	)	)	PUNCT
biomedich-872	73	41	.	.	PUNCT
biomedich-872	74	1	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	74	2	and	and	CCONJ
biomedich-872	74	3	toxicity	toxicity	NOUN
biomedich-872	74	4	predictions	prediction	NOUN
biomedich-872	74	5	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	74	6	and	and	CCONJ
biomedich-872	74	7	toxicity	toxicity	NOUN
biomedich-872	74	8	properties	property	NOUN
biomedich-872	74	9	of	of	ADP
biomedich-872	74	10	the	the	DET
biomedich-872	74	11	tested	test	VERB
biomedich-872	74	12	compounds	compound	NOUN
biomedich-872	74	13	were	be	AUX
biomedich-872	74	14	predicted	predict	VERB
biomedich-872	74	15	using	use	VERB
biomedich-872	74	16	admet	admet	PROPN
biomedich-872	74	17	(	(	PUNCT
biomedich-872	74	18	absorption	absorption	NOUN
biomedich-872	74	19	,	,	PUNCT
biomedich-872	74	20	distribution	distribution	NOUN
biomedich-872	74	21	,	,	PUNCT
biomedich-872	74	22	metabolism	metabolism	NOUN
biomedich-872	74	23	,	,	PUNCT
biomedich-872	74	24	excretion	excretion	NOUN
biomedich-872	74	25	,	,	PUNCT
biomedich-872	74	26	and	and	CCONJ
biomedich-872	74	27	toxicity	toxicity	NOUN
biomedich-872	74	28	)	)	PUNCT
biomedich-872	74	29	parameters	parameter	NOUN
biomedich-872	74	30	via	via	ADP
biomedich-872	74	31	the	the	DET
biomedich-872	74	32	pkcsm	pkcsm	NOUN
biomedich-872	74	33	online	online	ADJ
biomedich-872	74	34	platform	platform	NOUN
biomedich-872	74	35	(	(	PUNCT
biomedich-872	74	36	https://biosig.lab.uq.edu.au/pkcsm/prediction	https://biosig.lab.uq.edu.au/pkcsm/prediction	NOUN
biomedich-872	74	37	)	)	PUNCT
biomedich-872	74	38	.	.	PUNCT
biomedich-872	75	1	for	for	ADP
biomedich-872	75	2	this	this	DET
biomedich-872	75	3	analysis	analysis	NOUN
biomedich-872	75	4	,	,	PUNCT
biomedich-872	75	5	each	each	DET
biomedich-872	75	6	compound	compound	NOUN
biomedich-872	75	7	’s	’s	PART
biomedich-872	75	8	canonical	canonical	ADJ
biomedich-872	75	9	smiles	smile	NOUN
biomedich-872	75	10	notation	notation	NOUN
biomedich-872	75	11	was	be	AUX
biomedich-872	75	12	obtained	obtain	VERB
biomedich-872	75	13	from	from	ADP
biomedich-872	75	14	the	the	DET
biomedich-872	75	15	pubchem	pubchem	NOUN
biomedich-872	75	16	database	database	NOUN
biomedich-872	75	17	.	.	PUNCT
biomedich-872	76	1	key	key	ADJ
biomedich-872	76	2	parameters	parameter	NOUN
biomedich-872	76	3	evaluated	evaluate	VERB
biomedich-872	76	4	included	include	VERB
biomedich-872	76	5	intestinal	intestinal	ADJ
biomedich-872	76	6	absorption	absorption	NOUN
biomedich-872	76	7	percentage	percentage	NOUN
biomedich-872	76	8	,	,	PUNCT
biomedich-872	76	9	blood	blood	NOUN
biomedich-872	76	10	-	-	PUNCT
biomedich-872	76	11	brain	brain	NOUN
biomedich-872	76	12	barrier	barrier	NOUN
biomedich-872	76	13	(	(	PUNCT
biomedich-872	76	14	bbb	bbb	NOUN
biomedich-872	76	15	)	)	PUNCT
biomedich-872	76	16	permeability	permeability	NOUN
biomedich-872	76	17	,	,	PUNCT
biomedich-872	76	18	central	central	ADJ
biomedich-872	76	19	nervous	nervous	ADJ
biomedich-872	76	20	system	system	NOUN
biomedich-872	76	21	(	(	PUNCT
biomedich-872	76	22	cns	cns	NOUN
biomedich-872	76	23	)	)	PUNCT
biomedich-872	76	24	permeability	permeability	NOUN
biomedich-872	76	25	,	,	PUNCT
biomedich-872	76	26	substrate	substrate	NOUN
biomedich-872	76	27	specificity	specificity	NOUN
biomedich-872	76	28	for	for	ADP
biomedich-872	76	29	cytochrome	cytochrome	ADJ
biomedich-872	76	30	p450	p450	NUM
biomedich-872	76	31	enzymes	enzyme	NOUN
biomedich-872	76	32	cyp2d6	cyp2d6	NOUN
biomedich-872	76	33	and	and	CCONJ
biomedich-872	76	34	cyp3a4	cyp3a4	NOUN
biomedich-872	76	35	,	,	PUNCT
biomedich-872	76	36	total	total	ADJ
biomedich-872	76	37	clearance	clearance	NOUN
biomedich-872	76	38	rate	rate	NOUN
biomedich-872	76	39	(	(	PUNCT
biomedich-872	76	40	log	log	NOUN
biomedich-872	76	41	ml	ml	NOUN
biomedich-872	76	42	/	/	SYM
biomedich-872	76	43	min	min	NOUN
biomedich-872	76	44	/	/	SYM
biomedich-872	76	45	kg	kg	NOUN
biomedich-872	76	46	)	)	PUNCT
biomedich-872	76	47	,	,	PUNCT
biomedich-872	76	48	renal	renal	ADJ
biomedich-872	76	49	organic	organic	ADJ
biomedich-872	76	50	cation	cation	NOUN
biomedich-872	76	51	transporter	transporter	NOUN
biomedich-872	76	52	2	2	NUM
biomedich-872	76	53	(	(	PUNCT
biomedich-872	76	54	oct2	oct2	NOUN
biomedich-872	76	55	)	)	PUNCT
biomedich-872	76	56	substrate	substrate	NOUN
biomedich-872	76	57	status	status	NOUN
biomedich-872	76	58	,	,	PUNCT
biomedich-872	76	59	as	as	ADV
biomedich-872	76	60	well	well	ADV
biomedich-872	76	61	as	as	ADP
biomedich-872	76	62	toxicity	toxicity	NOUN
biomedich-872	76	63	profiles	profile	NOUN
biomedich-872	76	64	including	include	VERB
biomedich-872	76	65	ames	ame	NOUN
biomedich-872	76	66	mutagenicity	mutagenicity	NOUN
biomedich-872	76	67	and	and	CCONJ
biomedich-872	76	68	hepatotoxicity	hepatotoxicity	NOUN
biomedich-872	76	69	potential	potential	NOUN
biomedich-872	76	70	(	(	PUNCT
biomedich-872	76	71	utami	utami	NOUN
biomedich-872	76	72	et	et	PROPN
biomedich-872	76	73	al	al	PROPN
biomedich-872	76	74	.	.	PROPN
biomedich-872	76	75	,	,	PUNCT
biomedich-872	76	76	2025	2025	NUM
biomedich-872	76	77	)	)	PUNCT
biomedich-872	76	78	.	.	PUNCT
biomedich-872	77	1	results	result	NOUN
biomedich-872	77	2	and	and	CCONJ
biomedich-872	77	3	discussion	discussion	NOUN
biomedich-872	77	4	results	result	VERB
biomedich-872	77	5	the	the	DET
biomedich-872	77	6	pass	pass	NOUN
biomedich-872	77	7	online	online	ADJ
biomedich-872	77	8	analysis	analysis	NOUN
biomedich-872	77	9	revealed	reveal	VERB
biomedich-872	77	10	that	that	SCONJ
biomedich-872	77	11	several	several	ADJ
biomedich-872	77	12	compounds	compound	NOUN
biomedich-872	77	13	from	from	ADP
biomedich-872	77	14	physalis	physalis	NOUN
biomedich-872	77	15	angulata	angulata	ADJ
biomedich-872	77	16	possess	possess	NOUN
biomedich-872	77	17	predicted	predict	VERB
biomedich-872	77	18	pharmacological	pharmacological	ADJ
biomedich-872	77	19	activities	activity	NOUN
biomedich-872	77	20	related	relate	VERB
biomedich-872	77	21	to	to	ADP
biomedich-872	77	22	lung	lung	NOUN
biomedich-872	77	23	fibrosis	fibrosis	NOUN
biomedich-872	77	24	and	and	CCONJ
biomedich-872	77	25	lung	lung	NOUN
biomedich-872	77	26	cancer	cancer	NOUN
biomedich-872	77	27	.	.	PUNCT
biomedich-872	78	1	notably	notably	ADV
biomedich-872	78	2	,	,	PUNCT
biomedich-872	78	3	myricetrin	myricetrin	PROPN
biomedich-872	78	4	had	have	VERB
biomedich-872	78	5	the	the	DET
biomedich-872	78	6	highest	high	ADJ
biomedich-872	78	7	predicted	predict	VERB
biomedich-872	78	8	activity	activity	NOUN
biomedich-872	78	9	(	(	PUNCT
biomedich-872	78	10	pa	pa	NOUN
biomedich-872	78	11	=	=	PROPN
biomedich-872	78	12	0.479	0.479	NUM
biomedich-872	78	13	)	)	PUNCT
biomedich-872	78	14	for	for	ADP
biomedich-872	78	15	antineoplastic	antineoplastic	ADJ
biomedich-872	78	16	effects	effect	NOUN
biomedich-872	78	17	in	in	ADP
biomedich-872	78	18	lung	lung	NOUN
biomedich-872	78	19	cancer	cancer	NOUN
biomedich-872	78	20	,	,	PUNCT
biomedich-872	78	21	while	while	SCONJ
biomedich-872	78	22	also	also	ADV
biomedich-872	78	23	showing	show	VERB
biomedich-872	78	24	moderate	moderate	ADJ
biomedich-872	78	25	potential	potential	NOUN
biomedich-872	78	26	for	for	ADP
biomedich-872	78	27	cystic	cystic	ADJ
biomedich-872	78	28	fibrosis	fibrosis	NOUN
biomedich-872	78	29	treatment	treatment	NOUN
biomedich-872	78	30	(	(	PUNCT
biomedich-872	78	31	pa	pa	NOUN
biomedich-872	78	32	=	=	PROPN
biomedich-872	78	33	0.273	0.273	NUM
biomedich-872	78	34	)	)	PUNCT
biomedich-872	78	35	.	.	PUNCT
biomedich-872	79	1	rhoifolin	rhoifolin	NOUN
biomedich-872	79	2	exhibited	exhibit	VERB
biomedich-872	79	3	pa	pa	PROPN
biomedich-872	79	4	values	value	NOUN
biomedich-872	79	5	of	of	ADP
biomedich-872	79	6	0.478	0.478	NUM
biomedich-872	79	7	and	and	CCONJ
biomedich-872	79	8	0.306	0.306	NUM
biomedich-872	79	9	for	for	ADP
biomedich-872	79	10	lung	lung	NOUN
biomedich-872	79	11	cancer	cancer	NOUN
biomedich-872	79	12	and	and	CCONJ
biomedich-872	79	13	cystic	cystic	ADJ
biomedich-872	79	14	fibrosis	fibrosis	NOUN
biomedich-872	79	15	,	,	PUNCT
biomedich-872	79	16	respectively	respectively	ADV
biomedich-872	79	17	,	,	PUNCT
biomedich-872	79	18	indicating	indicate	VERB
biomedich-872	79	19	dual	dual	ADJ
biomedich-872	79	20	relevance	relevance	NOUN
biomedich-872	79	21	in	in	ADP
biomedich-872	79	22	antifibrotic	antifibrotic	ADJ
biomedich-872	79	23	and	and	CCONJ
biomedich-872	79	24	antineoplastic	antineoplastic	ADJ
biomedich-872	79	25	contexts	contexts	NOUN
biomedich-872	79	26	.	.	PUNCT
biomedich-872	80	1	apigenin	apigenin	VERB
biomedich-872	80	2	and	and	CCONJ
biomedich-872	80	3	kaempferol	kaempferol	NOUN
biomedich-872	80	4	both	both	PRON
biomedich-872	80	5	demonstrated	demonstrate	VERB
biomedich-872	80	6	moderate	moderate	ADJ
biomedich-872	80	7	activity	activity	NOUN
biomedich-872	80	8	predictions	prediction	NOUN
biomedich-872	80	9	for	for	ADP
biomedich-872	80	10	cystic	cystic	ADJ
biomedich-872	80	11	fibrosis	fibrosis	NOUN
biomedich-872	80	12	and	and	CCONJ
biomedich-872	80	13	small	small	ADJ
biomedich-872	80	14	cell	cell	NOUN
biomedich-872	80	15	lung	lung	NOUN
biomedich-872	80	16	cancer	cancer	NOUN
biomedich-872	80	17	,	,	PUNCT
biomedich-872	80	18	while	while	SCONJ
biomedich-872	80	19	hesperidin	hesperidin	NOUN
biomedich-872	80	20	showed	show	VERB
biomedich-872	80	21	a	a	DET
biomedich-872	80	22	pa	pa	NOUN
biomedich-872	80	23	of	of	ADP
biomedich-872	80	24	0.405	0.405	NUM
biomedich-872	80	25	for	for	ADP
biomedich-872	80	26	general	general	ADJ
biomedich-872	80	27	lung	lung	NOUN
biomedich-872	80	28	cancer	cancer	NOUN
biomedich-872	80	29	.	.	PUNCT
biomedich-872	81	1	tangeretin	tangeretin	VERB
biomedich-872	81	2	and	and	CCONJ
biomedich-872	81	3	naringin	naringin	NOUN
biomedich-872	81	4	also	also	ADV
biomedich-872	81	5	displayed	display	VERB
biomedich-872	81	6	potential	potential	ADJ
biomedich-872	81	7	with	with	ADP
biomedich-872	81	8	pa	pa	PROPN
biomedich-872	81	9	values	value	NOUN
biomedich-872	81	10	consistently	consistently	ADV
biomedich-872	81	11	near	near	ADP
biomedich-872	81	12	or	or	CCONJ
biomedich-872	81	13	above	above	ADP
biomedich-872	81	14	the	the	DET
biomedich-872	81	15	0.3	0.3	NUM
biomedich-872	81	16	threshold	threshold	NOUN
biomedich-872	81	17	across	across	ADP
biomedich-872	81	18	multiple	multiple	ADJ
biomedich-872	81	19	lung	lung	NOUN
biomedich-872	81	20	cancer	cancer	NOUN
biomedich-872	81	21	types	type	NOUN
biomedich-872	81	22	.	.	PUNCT
biomedich-872	82	1	these	these	DET
biomedich-872	82	2	findings	finding	NOUN
biomedich-872	82	3	suggest	suggest	VERB
biomedich-872	82	4	that	that	SCONJ
biomedich-872	82	5	multiple	multiple	ADJ
biomedich-872	82	6	flavonoids	flavonoid	NOUN
biomedich-872	82	7	from	from	ADP
biomedich-872	82	8	p.	p.	NOUN
biomedich-872	82	9	angulata	angulata	NOUN
biomedich-872	82	10	may	may	AUX
biomedich-872	82	11	interact	interact	VERB
biomedich-872	82	12	with	with	ADP
biomedich-872	82	13	targets	target	NOUN
biomedich-872	82	14	relevant	relevant	ADJ
biomedich-872	82	15	to	to	ADP
biomedich-872	82	16	fibrosis	fibrosis	NOUN
biomedich-872	82	17	and	and	CCONJ
biomedich-872	82	18	neoplastic	neoplastic	ADJ
biomedich-872	82	19	lung	lung	NOUN
biomedich-872	82	20	conditions	condition	NOUN
biomedich-872	82	21	(	(	PUNCT
biomedich-872	82	22	ananthathandavan	ananthathandavan	NOUN
biomedich-872	82	23	&	&	CCONJ
biomedich-872	82	24	narayanasamy	narayanasamy	NOUN
biomedich-872	82	25	,	,	PUNCT
biomedich-872	82	26	2024	2024	NUM
biomedich-872	82	27	)	)	PUNCT
biomedich-872	82	28	.	.	PUNCT
biomedich-872	83	1	redocking	redocking	NOUN
biomedich-872	83	2	was	be	AUX
biomedich-872	83	3	conducted	conduct	VERB
biomedich-872	83	4	using	use	VERB
biomedich-872	83	5	the	the	DET
biomedich-872	83	6	receptor	receptor	NOUN
biomedich-872	83	7	file	file	NOUN
biomedich-872	83	8	to	to	PART
biomedich-872	83	9	validate	validate	VERB
biomedich-872	83	10	the	the	DET
biomedich-872	83	11	accuracy	accuracy	NOUN
biomedich-872	83	12	of	of	ADP
biomedich-872	83	13	the	the	DET
biomedich-872	83	14	docking	docking	NOUN
biomedich-872	83	15	method	method	NOUN
biomedich-872	83	16	.	.	PUNCT
biomedich-872	84	1	the	the	DET
biomedich-872	84	2	grid	grid	PROPN
biomedich-872	84	3	box	box	PROPN
biomedich-872	84	4	was	be	AUX
biomedich-872	84	5	defined	define	VERB
biomedich-872	84	6	with	with	ADP
biomedich-872	84	7	center	center	NOUN
biomedich-872	84	8	coordinates	coordinate	NOUN
biomedich-872	84	9	at	at	ADP
biomedich-872	84	10	x	x	X
biomedich-872	84	11	=	=	SYM
biomedich-872	84	12	21.580	21.580	NUM
biomedich-872	84	13	,	,	PUNCT
biomedich-872	84	14	y	y	PROPN
biomedich-872	84	15	=	=	PROPN
biomedich-872	84	16	7.910	7.910	NUM
biomedich-872	84	17	,	,	PUNCT
biomedich-872	84	18	and	and	CCONJ
biomedich-872	84	19	z	z	NOUN
biomedich-872	84	20	=	=	SYM
biomedich-872	84	21	35.577	35.577	NUM
biomedich-872	84	22	,	,	PUNCT
biomedich-872	84	23	and	and	CCONJ
biomedich-872	84	24	dimensions	dimension	NOUN
biomedich-872	84	25	of	of	ADP
biomedich-872	84	26	14.153	14.153	NUM
biomedich-872	84	27	å	å	X
biomedich-872	84	28	(	(	PUNCT
biomedich-872	84	29	x	x	NOUN
biomedich-872	84	30	)	)	PUNCT
biomedich-872	84	31	,	,	PUNCT
biomedich-872	84	32	10.807	10.807	NUM
biomedich-872	84	33	å	å	PROPN
biomedich-872	84	34	(	(	PUNCT
biomedich-872	84	35	y	y	NOUN
biomedich-872	84	36	)	)	PUNCT
biomedich-872	84	37	,	,	PUNCT
biomedich-872	84	38	and	and	CCONJ
biomedich-872	84	39	4.976	4.976	NUM
biomedich-872	84	40	å	å	PROPN
biomedich-872	84	41	(	(	PUNCT
biomedich-872	84	42	z	z	NOUN
biomedich-872	84	43	)	)	PUNCT
biomedich-872	84	44	.	.	PUNCT
biomedich-872	85	1	the	the	DET
biomedich-872	85	2	evaluation	evaluation	NOUN
biomedich-872	85	3	yielded	yield	VERB
biomedich-872	85	4	an	an	DET
biomedich-872	85	5	rmsd	rmsd	ADJ
biomedich-872	85	6	value	value	NOUN
biomedich-872	85	7	of	of	ADP
biomedich-872	85	8	0.893	0.893	NUM
biomedich-872	85	9	å	å	PROPN
biomedich-872	85	10	based	base	VERB
biomedich-872	85	11	on	on	ADP
biomedich-872	85	12	the	the	DET
biomedich-872	85	13	alignment	alignment	NOUN
biomedich-872	85	14	of	of	ADP
biomedich-872	85	15	27	27	NUM
biomedich-872	85	16	atoms	atom	NOUN
biomedich-872	85	17	,	,	PUNCT
biomedich-872	85	18	confirming	confirm	VERB
biomedich-872	85	19	that	that	SCONJ
biomedich-872	85	20	the	the	DET
biomedich-872	85	21	predicted	predict	VERB
biomedich-872	85	22	ligand	ligand	NOUN
biomedich-872	85	23	conformation	conformation	NOUN
biomedich-872	85	24	closely	closely	ADV
biomedich-872	85	25	resembled	resemble	VERB
biomedich-872	85	26	the	the	DET
biomedich-872	85	27	original	original	ADJ
biomedich-872	85	28	pose	pose	NOUN
biomedich-872	85	29	(	(	PUNCT
biomedich-872	85	30	farid	farid	PROPN
biomedich-872	85	31	et	et	PROPN
biomedich-872	85	32	al	al	PROPN
biomedich-872	85	33	.	.	PROPN
biomedich-872	85	34	,	,	PUNCT
biomedich-872	85	35	2025	2025	NUM
biomedich-872	85	36	)	)	PUNCT
biomedich-872	85	37	.	.	PUNCT
biomedich-872	86	1	this	this	PRON
biomedich-872	86	2	indicates	indicate	VERB
biomedich-872	86	3	that	that	SCONJ
biomedich-872	86	4	the	the	DET
biomedich-872	86	5	docking	docking	NOUN
biomedich-872	86	6	protocol	protocol	NOUN
biomedich-872	86	7	was	be	AUX
biomedich-872	86	8	valid	valid	ADJ
biomedich-872	86	9	and	and	CCONJ
biomedich-872	86	10	reliable	reliable	ADJ
biomedich-872	86	11	.	.	PUNCT
biomedich-872	87	1	the	the	DET
biomedich-872	87	2	determined	determined	ADJ
biomedich-872	87	3	grid	grid	NOUN
biomedich-872	87	4	parameters	parameter	NOUN
biomedich-872	87	5	were	be	AUX
biomedich-872	87	6	subsequently	subsequently	ADV
biomedich-872	87	7	used	use	VERB
biomedich-872	87	8	for	for	ADP
biomedich-872	87	9	the	the	DET
biomedich-872	87	10	main	main	ADJ
biomedich-872	87	11	docking	docking	NOUN
biomedich-872	87	12	simulations	simulation	NOUN
biomedich-872	87	13	.	.	PUNCT
biomedich-872	88	1	figure	figure	NOUN
biomedich-872	88	2	1	1	NUM
biomedich-872	88	3	.	.	PUNCT
biomedich-872	88	4	native	native	ADJ
biomedich-872	88	5	ligand	ligand	PROPN
biomedich-872	88	6	before	before	ADV
biomedich-872	88	7	(	(	PUNCT
biomedich-872	88	8	green	green	ADJ
biomedich-872	88	9	)	)	PUNCT
biomedich-872	88	10	and	and	CCONJ
biomedich-872	88	11	after	after	ADP
biomedich-872	88	12	(	(	PUNCT
biomedich-872	88	13	yellow	yellow	ADJ
biomedich-872	88	14	)	)	PUNCT
biomedich-872	88	15	redocking	redocking	NOUN
biomedich-872	88	16	.	.	PUNCT
biomedich-872	89	1	molecular	molecular	ADJ
biomedich-872	89	2	docking	docking	NOUN
biomedich-872	89	3	simulations	simulation	NOUN
biomedich-872	89	4	produced	produce	VERB
biomedich-872	89	5	varied	varied	ADJ
biomedich-872	89	6	binding	bind	VERB
biomedich-872	89	7	affinity	affinity	NOUN
biomedich-872	89	8	values	value	NOUN
biomedich-872	89	9	for	for	ADP
biomedich-872	89	10	the	the	DET
biomedich-872	89	11	tested	test	VERB
biomedich-872	89	12	compounds	compound	NOUN
biomedich-872	89	13	against	against	ADP
biomedich-872	89	14	the	the	DET
biomedich-872	89	15	pi3k	pi3k	PROPN
biomedich-872	89	16	/	/	SYM
biomedich-872	89	17	akt	akt	PROPN
biomedich-872	89	18	target	target	NOUN
biomedich-872	89	19	.	.	PUNCT
biomedich-872	90	1	myricetrin	myricetrin	PROPN
biomedich-872	90	2	exhibited	exhibit	VERB
biomedich-872	90	3	the	the	DET
biomedich-872	90	4	strongest	strong	ADJ
biomedich-872	90	5	binding	bind	VERB
biomedich-872	90	6	affinity	affinity	NOUN
biomedich-872	90	7	at	at	ADP
biomedich-872	90	8	-9.6	-9.6	ADP
biomedich-872	90	9	kcal	kcal	NOUN
biomedich-872	90	10	/	/	SYM
biomedich-872	90	11	mol	mol	PROPN
biomedich-872	90	12	,	,	PUNCT
biomedich-872	90	13	surpassing	surpass	VERB
biomedich-872	90	14	even	even	ADV
biomedich-872	90	15	the	the	DET
biomedich-872	90	16	native	native	ADJ
biomedich-872	90	17	ligand	ligand	NOUN
biomedich-872	90	18	at	at	ADP
biomedich-872	90	19	-9.1	-9.1	PROPN
biomedich-872	90	20	kcal	kcal	PROPN
biomedich-872	90	21	/	/	SYM
biomedich-872	90	22	mol	mol	PROPN
biomedich-872	90	23	.	.	PUNCT
biomedich-872	91	1	other	other	ADJ
biomedich-872	91	2	compounds	compound	NOUN
biomedich-872	91	3	such	such	ADJ
biomedich-872	91	4	as	as	ADP
biomedich-872	91	5	eriodictyol	eriodictyol	NOUN
biomedich-872	91	6	(	(	PUNCT
biomedich-872	91	7	-8.9	-8.9	INTJ
biomedich-872	91	8	kcal	kcal	PROPN
biomedich-872	91	9	/	/	SYM
biomedich-872	91	10	mol	mol	NOUN
biomedich-872	91	11	)	)	PUNCT
biomedich-872	91	12	,	,	PUNCT
biomedich-872	91	13	naringin	naringin	PROPN
biomedich-872	91	14	(	(	PUNCT
biomedich-872	91	15	-8.8	-8.8	PROPN
biomedich-872	91	16	kcal	kcal	PROPN
biomedich-872	91	17	/	/	SYM
biomedich-872	91	18	mol	mol	NOUN
biomedich-872	91	19	)	)	PUNCT
biomedich-872	91	20	,	,	PUNCT
biomedich-872	91	21	epigallocatechin	epigallocatechin	NOUN
biomedich-872	91	22	(	(	PUNCT
biomedich-872	91	23	-8.6kcal	-8.6kcal	ADJ
biomedich-872	91	24	/	/	SYM
biomedich-872	91	25	mol	mol	NOUN
biomedich-872	91	26	)	)	PUNCT
biomedich-872	91	27	,	,	PUNCT
biomedich-872	91	28	apigenin	apigenin	PROPN
biomedich-872	91	29	(	(	PUNCT
biomedich-872	91	30	-8.5	-8.5	INTJ
biomedich-872	91	31	kcal	kcal	PROPN
biomedich-872	91	32	/	/	SYM
biomedich-872	91	33	mol	mol	NOUN
biomedich-872	91	34	)	)	PUNCT
biomedich-872	91	35	,	,	PUNCT
biomedich-872	91	36	and	and	CCONJ
biomedich-872	91	37	kaempferol	kaempferol	NOUN
biomedich-872	91	38	(	(	PUNCT
biomedich-872	91	39	-8.3	-8.3	ADP
biomedich-872	91	40	kcal	kcal	PROPN
biomedich-872	91	41	/	/	SYM
biomedich-872	91	42	mol	mol	NOUN
biomedich-872	91	43	)	)	PUNCT
biomedich-872	91	44	also	also	ADV
biomedich-872	91	45	demonstrated	demonstrate	VERB
biomedich-872	91	46	strong	strong	ADJ
biomedich-872	91	47	interactions	interaction	NOUN
biomedich-872	91	48	.	.	PUNCT
biomedich-872	92	1	conversely	conversely	ADV
biomedich-872	92	2	,	,	PUNCT
biomedich-872	92	3	compounds	compound	NOUN
biomedich-872	92	4	like	like	ADP
biomedich-872	92	5	hesperidin	hesperidin	VERB
biomedich-872	92	6	(	(	PUNCT
biomedich-872	92	7	4.8	4.8	NUM
biomedich-872	92	8	kcal	kcal	NOUN
biomedich-872	92	9	/	/	SYM
biomedich-872	92	10	mol	mol	NOUN
biomedich-872	92	11	)	)	PUNCT
biomedich-872	92	12	and	and	CCONJ
biomedich-872	92	13	rhoifolin	rhoifolin	NOUN
biomedich-872	92	14	(	(	PUNCT
biomedich-872	92	15	-4.9	-4.9	PROPN
biomedich-872	92	16	kcal	kcal	PROPN
biomedich-872	92	17	/	/	SYM
biomedich-872	92	18	mol	mol	NOUN
biomedich-872	92	19	)	)	PUNCT
biomedich-872	92	20	showed	show	VERB
biomedich-872	92	21	the	the	DET
biomedich-872	92	22	weakest	weak	ADJ
biomedich-872	92	23	binding	bind	VERB
biomedich-872	92	24	affinities	affinity	NOUN
biomedich-872	92	25	.	.	PUNCT
biomedich-872	93	1	the	the	DET
biomedich-872	93	2	reference	reference	NOUN
biomedich-872	93	3	drug	drug	NOUN
biomedich-872	93	4	nintedanib	nintedanib	NOUN
biomedich-872	93	5	showed	show	VERB
biomedich-872	93	6	a	a	DET
biomedich-872	93	7	positive	positive	ADJ
biomedich-872	93	8	binding	bind	VERB
biomedich-872	93	9	energy	energy	NOUN
biomedich-872	93	10	of	of	ADP
biomedich-872	93	11	+1.73	+1.73	PROPN
biomedich-872	93	12	kcal	kcal	PROPN
biomedich-872	93	13	/	/	SYM
biomedich-872	93	14	mol	mol	PROPN
biomedich-872	93	15	,	,	PUNCT
biomedich-872	93	16	which	which	PRON
biomedich-872	93	17	may	may	AUX
biomedich-872	93	18	suggest	suggest	VERB
biomedich-872	93	19	poor	poor	ADJ
biomedich-872	93	20	binding	bind	VERB
biomedich-872	93	21	affinity	affinity	NOUN
biomedich-872	93	22	under	under	ADP
biomedich-872	93	23	these	these	DET
biomedich-872	93	24	docking	docking	NOUN
biomedich-872	93	25	parameters	parameter	NOUN
biomedich-872	93	26	.	.	PUNCT
biomedich-872	94	1	https://biosig.lab.uq.edu.au/pkcsm/prediction	https://biosig.lab.uq.edu.au/pkcsm/prediction	NOUN
biomedich-872	94	2	820	820	NUM
biomedich-872	94	3	biology	biology	NOUN
biomedich-872	94	4	,	,	PUNCT
biomedich-872	94	5	medicine	medicine	NOUN
biomedich-872	94	6	,	,	PUNCT
biomedich-872	94	7	&	&	CCONJ
biomedich-872	94	8	natural	natural	ADJ
biomedich-872	94	9	product	product	NOUN
biomedich-872	94	10	chemistry	chemistry	NOUN
biomedich-872	94	11	14	14	NUM
biomedich-872	94	12	(	(	PUNCT
biomedich-872	94	13	2	2	NUM
biomedich-872	94	14	)	)	PUNCT
biomedich-872	94	15	,	,	PUNCT
biomedich-872	94	16	2025	2025	NUM
biomedich-872	94	17	:	:	PUNCT
biomedich-872	94	18	817	817	NUM
biomedich-872	94	19	-	-	SYM
biomedich-872	94	20	824	824	NUM
biomedich-872	94	21	table	table	NOUN
biomedich-872	94	22	1	1	NUM
biomedich-872	94	23	.	.	PUNCT
biomedich-872	95	1	docking	dock	VERB
biomedich-872	95	2	scores	score	NOUN
biomedich-872	95	3	and	and	CCONJ
biomedich-872	95	4	amino	amino	NOUN
biomedich-872	95	5	acid	acid	NOUN
biomedich-872	95	6	interactions	interaction	NOUN
biomedich-872	95	7	.	.	PUNCT
biomedich-872	96	1	compound	compound	VERB
biomedich-872	96	2	δg	δg	ADP
biomedich-872	96	3	(	(	PUNCT
biomedich-872	96	4	kcal	kcal	PROPN
biomedich-872	96	5	/	/	SYM
biomedich-872	96	6	mol	mol	NOUN
biomedich-872	96	7	)	)	PUNCT
biomedich-872	96	8	hydrogen	hydrogen	NOUN
biomedich-872	96	9	bonding	bonding	NOUN
biomedich-872	96	10	amino	amino	NOUN
biomedich-872	96	11	acids	acid	NOUN
biomedich-872	96	12	non	non	ADJ
biomedich-872	96	13	-	-	ADJ
biomedich-872	96	14	hydrogen	hydrogen	ADJ
biomedich-872	96	15	bonding	bonding	NOUN
biomedich-872	96	16	amino	amino	NOUN
biomedich-872	96	17	acids	acid	NOUN
biomedich-872	96	18	native	native	ADJ
biomedich-872	96	19	ligand	ligand	PROPN
biomedich-872	96	20	-9.1	-9.1	PROPN
biomedich-872	96	21	arg18	arg18	PROPN
biomedich-872	96	22	,	,	PUNCT
biomedich-872	96	23	thr51	thr51	NOUN
biomedich-872	96	24	val57	val57	PROPN
biomedich-872	96	25	,	,	PUNCT
biomedich-872	96	26	ala70	ala70	PROPN
biomedich-872	96	27	,	,	PUNCT
biomedich-872	96	28	leu173	leu173	PROPN
biomedich-872	96	29	,	,	PUNCT
biomedich-872	96	30	asp184	asp184	PROPN
biomedich-872	96	31	,	,	PUNCT
biomedich-872	96	32	met120	met120	NOUN
biomedich-872	96	33	,	,	PUNCT
biomedich-872	96	34	lys72	lys72	NOUN
biomedich-872	96	35	rhoifolin	rhoifolin	PROPN
biomedich-872	96	36	-4.9	-4.9	PROPN
biomedich-872	96	37	asp184	asp184	PROPN
biomedich-872	96	38	,	,	PUNCT
biomedich-872	96	39	lys72	lys72	NOUN
biomedich-872	96	40	,	,	PUNCT
biomedich-872	96	41	asn171	asn171	PROPN
biomedich-872	96	42	,	,	PUNCT
biomedich-872	96	43	gly50	gly50	PROPN
biomedich-872	96	44	,	,	PUNCT
biomedich-872	96	45	ser53	ser53	PROPN
biomedich-872	96	46	val57	val57	PROPN
biomedich-872	96	47	,	,	PUNCT
biomedich-872	96	48	leu173	leu173	PROPN
biomedich-872	96	49	,	,	PUNCT
biomedich-872	96	50	ala70	ala70	NOUN
biomedich-872	96	51	,	,	PUNCT
biomedich-872	96	52	val123	val123	PROPN
biomedich-872	96	53	,	,	PUNCT
biomedich-872	96	54	leu49	leu49	NOUN
biomedich-872	96	55	,	,	PUNCT
biomedich-872	96	56	met120	met120	NOUN
biomedich-872	96	57	,	,	PUNCT
biomedich-872	96	58	lys72	lys72	NOUN
biomedich-872	96	59	tangeretin	tangeretin	NOUN
biomedich-872	96	60	-8.2	-8.2	PUNCT
biomedich-872	96	61	glu121	glu121	NOUN
biomedich-872	96	62	,	,	PUNCT
biomedich-872	96	63	thr51	thr51	NOUN
biomedich-872	96	64	,	,	PUNCT
biomedich-872	96	65	lys72	lys72	NOUN
biomedich-872	96	66	val57	val57	PROPN
biomedich-872	96	67	,	,	PUNCT
biomedich-872	96	68	leu173	leu173	PROPN
biomedich-872	96	69	,	,	PUNCT
biomedich-872	96	70	ala70	ala70	NOUN
biomedich-872	96	71	,	,	PUNCT
biomedich-872	96	72	val123	val123	PROPN
biomedich-872	96	73	,	,	PUNCT
biomedich-872	96	74	met120	met120	NOUN
biomedich-872	96	75	,	,	PUNCT
biomedich-872	96	76	asp184	asp184	PROPN
biomedich-872	96	77	,	,	PUNCT
biomedich-872	96	78	arg18	arg18	PROPN
biomedich-872	96	79	eriodictyol	eriodictyol	PROPN
biomedich-872	96	80	-8.9	-8.9	PROPN
biomedich-872	96	81	lys72	lys72	PROPN
biomedich-872	96	82	,	,	PUNCT
biomedich-872	96	83	glu121	glu121	NOUN
biomedich-872	96	84	,	,	PUNCT
biomedich-872	96	85	thr51	thr51	NOUN
biomedich-872	96	86	val57	val57	PROPN
biomedich-872	96	87	,	,	PUNCT
biomedich-872	96	88	ala70	ala70	PROPN
biomedich-872	96	89	,	,	PUNCT
biomedich-872	96	90	leu173	leu173	PROPN
biomedich-872	96	91	,	,	PUNCT
biomedich-872	96	92	val104	val104	PROPN
biomedich-872	96	93	,	,	PUNCT
biomedich-872	96	94	met120	met120	PROPN
biomedich-872	96	95	,	,	PUNCT
biomedich-872	96	96	thr183	thr183	PROPN
biomedich-872	96	97	,	,	PUNCT
biomedich-872	96	98	asp184	asp184	PROPN
biomedich-872	96	99	,	,	PUNCT
biomedich-872	96	100	arg18	arg18	NOUN
biomedich-872	96	101	catechin	catechin	NOUN
biomedich-872	96	102	-8.2	-8.2	PROPN
biomedich-872	96	103	—	—	PUNCT
biomedich-872	96	104	val57	val57	PROPN
biomedich-872	96	105	,	,	PUNCT
biomedich-872	96	106	leu173	leu173	PROPN
biomedich-872	96	107	,	,	PUNCT
biomedich-872	96	108	ala70	ala70	NOUN
biomedich-872	96	109	,	,	PUNCT
biomedich-872	96	110	asp184	asp184	PROPN
biomedich-872	96	111	naringin	naringin	VERB
biomedich-872	96	112	-8.8	-8.8	PROPN
biomedich-872	96	113	glu127	glu127	PROPN
biomedich-872	96	114	,	,	PUNCT
biomedich-872	96	115	val123	val123	PROPN
biomedich-872	96	116	,	,	PUNCT
biomedich-872	96	117	leu49	leu49	NOUN
biomedich-872	96	118	,	,	PUNCT
biomedich-872	96	119	asp184	asp184	PROPN
biomedich-872	96	120	,	,	PUNCT
biomedich-872	96	121	ser53	ser53	PROPN
biomedich-872	96	122	val57	val57	PROPN
biomedich-872	96	123	,	,	PUNCT
biomedich-872	96	124	ala70	ala70	PROPN
biomedich-872	96	125	,	,	PUNCT
biomedich-872	96	126	leu173	leu173	PROPN
biomedich-872	96	127	,	,	PUNCT
biomedich-872	96	128	lys72	lys72	NOUN
biomedich-872	96	129	,	,	PUNCT
biomedich-872	96	130	asn171	asn171	PROPN
biomedich-872	96	131	,	,	PUNCT
biomedich-872	96	132	leu49	leu49	NOUN
biomedich-872	96	133	,	,	PUNCT
biomedich-872	96	134	asp184	asp184	NOUN
biomedich-872	96	135	myricetrin	myricetrin	NOUN
biomedich-872	96	136	-9.6	-9.6	PROPN
biomedich-872	96	137	glu121	glu121	PROPN
biomedich-872	96	138	,	,	PUNCT
biomedich-872	96	139	glu170	glu170	PROPN
biomedich-872	96	140	,	,	PUNCT
biomedich-872	96	141	asp184	asp184	PROPN
biomedich-872	96	142	,	,	PUNCT
biomedich-872	96	143	asn171	asn171	PROPN
biomedich-872	96	144	,	,	PUNCT
biomedich-872	96	145	gly50	gly50	PROPN
biomedich-872	96	146	val57	val57	PROPN
biomedich-872	96	147	,	,	PUNCT
biomedich-872	96	148	ala70	ala70	PROPN
biomedich-872	96	149	,	,	PUNCT
biomedich-872	96	150	leu173	leu173	PROPN
biomedich-872	96	151	,	,	PUNCT
biomedich-872	96	152	tyr330	tyr330	PROPN
biomedich-872	96	153	kaempferol	kaempferol	NOUN
biomedich-872	96	154	-8.3	-8.3	ADJ
biomedich-872	96	155	glu121	glu121	NOUN
biomedich-872	96	156	,	,	PUNCT
biomedich-872	96	157	asp184	asp184	PROPN
biomedich-872	96	158	val57	val57	PROPN
biomedich-872	96	159	,	,	PUNCT
biomedich-872	96	160	ala70	ala70	PROPN
biomedich-872	96	161	,	,	PUNCT
biomedich-872	96	162	leu173	leu173	PROPN
biomedich-872	96	163	,	,	PUNCT
biomedich-872	96	164	thr183	thr183	PROPN
biomedich-872	96	165	,	,	PUNCT
biomedich-872	96	166	asp184	asp184	PROPN
biomedich-872	96	167	hesperidin	hesperidin	NOUN
biomedich-872	96	168	-4.8	-4.8	VERB
biomedich-872	96	169	glu121	glu121	NOUN
biomedich-872	96	170	,	,	PUNCT
biomedich-872	96	171	val123	val123	PROPN
biomedich-872	96	172	,	,	PUNCT
biomedich-872	96	173	lys72	lys72	NOUN
biomedich-872	96	174	,	,	PUNCT
biomedich-872	96	175	asp184	asp184	PROPN
biomedich-872	96	176	val57	val57	PROPN
biomedich-872	96	177	,	,	PUNCT
biomedich-872	96	178	leu173	leu173	PROPN
biomedich-872	96	179	,	,	PUNCT
biomedich-872	96	180	gly50	gly50	PROPN
biomedich-872	96	181	,	,	PUNCT
biomedich-872	96	182	thr183	thr183	PROPN
biomedich-872	96	183	epigallocatechin	epigallocatechin	PROPN
biomedich-872	96	184	-8.6	-8.6	PROPN
biomedich-872	96	185	glu121	glu121	PROPN
biomedich-872	96	186	,	,	PUNCT
biomedich-872	96	187	tyr330	tyr330	PROPN
biomedich-872	96	188	,	,	PUNCT
biomedich-872	96	189	leu49	leu49	NOUN
biomedich-872	96	190	,	,	PUNCT
biomedich-872	96	191	glu127	glu127	PROPN
biomedich-872	96	192	,	,	PUNCT
biomedich-872	96	193	arg18	arg18	PROPN
biomedich-872	96	194	,	,	PUNCT
biomedich-872	96	195	thr51	thr51	NOUN
biomedich-872	96	196	val57	val57	PROPN
biomedich-872	96	197	,	,	PUNCT
biomedich-872	96	198	ala70	ala70	PROPN
biomedich-872	96	199	,	,	PUNCT
biomedich-872	96	200	leu173	leu173	PROPN
biomedich-872	96	201	,	,	PUNCT
biomedich-872	96	202	gly50	gly50	PROPN
biomedich-872	96	203	apigenin	apigenin	VERB
biomedich-872	96	204	-8.5	-8.5	INTJ
biomedich-872	96	205	glu121	glu121	PROPN
biomedich-872	96	206	,	,	PUNCT
biomedich-872	96	207	gly50	gly50	PROPN
biomedich-872	96	208	val57	val57	PROPN
biomedich-872	96	209	,	,	PUNCT
biomedich-872	96	210	leu173	leu173	PROPN
biomedich-872	96	211	,	,	PUNCT
biomedich-872	96	212	ala70	ala70	NOUN
biomedich-872	96	213	,	,	PUNCT
biomedich-872	96	214	met120	met120	PROPN
biomedich-872	96	215	,	,	PUNCT
biomedich-872	96	216	val104	val104	PROPN
biomedich-872	96	217	,	,	PUNCT
biomedich-872	96	218	thr183	thr183	PROPN
biomedich-872	96	219	nintedanib	nintedanib	NOUN
biomedich-872	96	220	+1.73	+1.73	PROPN
biomedich-872	96	221	asp264	asp264	PROPN
biomedich-872	96	222	,	,	PUNCT
biomedich-872	96	223	thr299	thr299	NOUN
biomedich-872	96	224	—	—	PUNCT
biomedich-872	96	225	the	the	DET
biomedich-872	96	226	docking	docking	NOUN
biomedich-872	96	227	results	result	NOUN
biomedich-872	96	228	also	also	ADV
biomedich-872	96	229	identified	identify	VERB
biomedich-872	96	230	key	key	ADJ
biomedich-872	96	231	amino	amino	NOUN
biomedich-872	96	232	acid	acid	NOUN
biomedich-872	96	233	residues	residue	NOUN
biomedich-872	96	234	involved	involve	VERB
biomedich-872	96	235	in	in	ADP
biomedich-872	96	236	the	the	DET
biomedich-872	96	237	interactions	interaction	NOUN
biomedich-872	96	238	.	.	PUNCT
biomedich-872	97	1	non	non	ADJ
biomedich-872	97	2	-	-	ADJ
biomedich-872	97	3	hydrogen	hydrogen	ADJ
biomedich-872	97	4	bonding	bonding	NOUN
biomedich-872	97	5	interactions	interaction	NOUN
biomedich-872	97	6	were	be	AUX
biomedich-872	97	7	most	most	ADV
biomedich-872	97	8	commonly	commonly	ADV
biomedich-872	97	9	observed	observe	VERB
biomedich-872	97	10	with	with	ADP
biomedich-872	97	11	residues	residue	NOUN
biomedich-872	97	12	val57	val57	PROPN
biomedich-872	97	13	,	,	PUNCT
biomedich-872	97	14	leu173	leu173	PROPN
biomedich-872	97	15	,	,	PUNCT
biomedich-872	97	16	and	and	CCONJ
biomedich-872	97	17	ala70	ala70	NOUN
biomedich-872	97	18	across	across	ADP
biomedich-872	97	19	nearly	nearly	ADV
biomedich-872	97	20	all	all	PRON
biomedich-872	97	21	ligands	ligand	NOUN
biomedich-872	97	22	.	.	PUNCT
biomedich-872	98	1	in	in	ADP
biomedich-872	98	2	terms	term	NOUN
biomedich-872	98	3	of	of	ADP
biomedich-872	98	4	hydrogen	hydrogen	NOUN
biomedich-872	98	5	bonding	bonding	NOUN
biomedich-872	98	6	,	,	PUNCT
biomedich-872	98	7	asp184	asp184	PROPN
biomedich-872	98	8	,	,	PUNCT
biomedich-872	98	9	glu121	glu121	NOUN
biomedich-872	98	10	,	,	PUNCT
biomedich-872	98	11	and	and	CCONJ
biomedich-872	98	12	lys72	lys72	NOUN
biomedich-872	98	13	were	be	AUX
biomedich-872	98	14	among	among	ADP
biomedich-872	98	15	the	the	DET
biomedich-872	98	16	most	most	ADV
biomedich-872	98	17	frequently	frequently	ADV
biomedich-872	98	18	engaged	engage	VERB
biomedich-872	98	19	residues	residue	NOUN
biomedich-872	98	20	.	.	PUNCT
biomedich-872	99	1	notably	notably	ADV
biomedich-872	99	2	,	,	PUNCT
biomedich-872	99	3	asp184	asp184	PROPN
biomedich-872	99	4	formed	form	VERB
biomedich-872	99	5	hydrogen	hydrogen	NOUN
biomedich-872	99	6	bonds	bond	NOUN
biomedich-872	99	7	with	with	ADP
biomedich-872	99	8	eight	eight	NUM
biomedich-872	99	9	of	of	ADP
biomedich-872	99	10	the	the	DET
biomedich-872	99	11	eleven	eleven	NUM
biomedich-872	99	12	tested	test	VERB
biomedich-872	99	13	ligands	ligand	NOUN
biomedich-872	99	14	,	,	PUNCT
biomedich-872	99	15	highlighting	highlight	VERB
biomedich-872	99	16	its	its	PRON
biomedich-872	99	17	importance	importance	NOUN
biomedich-872	99	18	in	in	ADP
biomedich-872	99	19	ligand	ligand	ADJ
biomedich-872	99	20	recognition	recognition	NOUN
biomedich-872	99	21	.	.	PUNCT
biomedich-872	100	1	table	table	NOUN
biomedich-872	100	2	2	2	NUM
biomedich-872	100	3	.	.	PUNCT
biomedich-872	100	4	predicted	predict	VERB
biomedich-872	100	5	admet	admet	NOUN
biomedich-872	100	6	profiles	profile	NOUN
biomedich-872	100	7	of	of	ADP
biomedich-872	100	8	selected	select	VERB
biomedich-872	100	9	compounds	compound	NOUN
biomedich-872	100	10	.	.	PUNCT
biomedich-872	101	1	compound	compound	NOUN
biomedich-872	101	2	absorption	absorption	NOUN
biomedich-872	101	3	(	(	PUNCT
biomedich-872	101	4	%	%	INTJ
biomedich-872	101	5	)	)	PUNCT
biomedich-872	101	6	bbb	bbb	NOUN
biomedich-872	101	7	penetration	penetration	NOUN
biomedich-872	101	8	cns	cns	NOUN
biomedich-872	101	9	penetration	penetration	NOUN
biomedich-872	101	10	cyp3a4	cyp3a4	NOUN
biomedich-872	101	11	substrate	substrate	NOUN
biomedich-872	101	12	clearance	clearance	NOUN
biomedich-872	101	13	ames	ame	NOUN
biomedich-872	101	14	toxicity	toxicity	NOUN
biomedich-872	101	15	hepatotoxicity	hepatotoxicity	NOUN
biomedich-872	101	16	rhoifolin	rhoifolin	NOUN
biomedich-872	101	17	24.3	24.3	NUM
biomedich-872	101	18	-1.702	-1.702	NUM
biomedich-872	101	19	-4.798	-4.798	NOUN
biomedich-872	102	1	no	no	INTJ
biomedich-872	102	2	-0.005	-0.005	INTJ
biomedich-872	102	3	no	no	INTJ
biomedich-872	102	4	no	no	INTJ
biomedich-872	102	5	tangeretin	tangeretin	NOUN
biomedich-872	102	6	98.5	98.5	NUM
biomedich-872	102	7	-1.026	-1.026	SYM
biomedich-872	102	8	-3.011	-3.011	INTJ
biomedich-872	102	9	yes	yes	ADV
biomedich-872	102	10	0.780	0.780	NUM
biomedich-872	102	11	no	no	INTJ
biomedich-872	102	12	no	no	DET
biomedich-872	102	13	eriodictyol	eriodictyol	NOUN
biomedich-872	102	14	74.7	74.7	NUM
biomedich-872	102	15	-0.827	-0.827	NUM
biomedich-872	102	16	-3.142	-3.142	INTJ
biomedich-872	103	1	no	no	INTJ
biomedich-872	103	2	-0.013	-0.013	NOUN
biomedich-872	104	1	no	no	INTJ
biomedich-872	104	2	no	no	DET
biomedich-872	104	3	catechin	catechin	NOUN
biomedich-872	104	4	68.8	68.8	NUM
biomedich-872	104	5	-1.054	-1.054	NOUN
biomedich-872	104	6	-3.298	-3.298	PUNCT
biomedich-872	104	7	no	no	DET
biomedich-872	104	8	0.183	0.183	NUM
biomedich-872	104	9	no	no	INTJ
biomedich-872	105	1	no	no	INTJ
biomedich-872	105	2	naringin	naringin	NOUN
biomedich-872	105	3	25.8	25.8	NUM
biomedich-872	105	4	-1.600	-1.600	ADP
biomedich-872	105	5	-4.773	-4.773	NOUN
biomedich-872	106	1	no	no	INTJ
biomedich-872	106	2	0.318	0.318	NUM
biomedich-872	106	3	no	no	INTJ
biomedich-872	106	4	no	no	DET
biomedich-872	106	5	myricetrin	myricetrin	NOUN
biomedich-872	106	6	43.3	43.3	NUM
biomedich-872	106	7	-1.811	-1.811	NUM
biomedich-872	106	8	-4.376	-4.376	VERB
biomedich-872	106	9	no	no	ADV
biomedich-872	106	10	0.303	0.303	NUM
biomedich-872	106	11	no	no	INTJ
biomedich-872	106	12	no	no	DET
biomedich-872	106	13	kaempferol	kaempferol	NOUN
biomedich-872	106	14	74.3	74.3	NUM
biomedich-872	106	15	-0.939	-0.939	NUM
biomedich-872	106	16	-2.228	-2.228	PROPN
biomedich-872	106	17	no	no	DET
biomedich-872	106	18	0.477	0.477	NOUN
biomedich-872	106	19	no	no	INTJ
biomedich-872	106	20	no	no	DET
biomedich-872	106	21	hesperidin	hesperidin	VERB
biomedich-872	106	22	31.5	31.5	NUM
biomedich-872	106	23	-1.715	-1.715	NOUN
biomedich-872	106	24	-4.807	-4.807	PUNCT
biomedich-872	106	25	no	no	DET
biomedich-872	106	26	0.211	0.211	NUM
biomedich-872	106	27	no	no	INTJ
biomedich-872	106	28	no	no	DET
biomedich-872	106	29	epigallocatechin	epigallocatechin	NOUN
biomedich-872	106	30	54.1	54.1	NUM
biomedich-872	106	31	-1.377	-1.377	NOUN
biomedich-872	106	32	-3.507	-3.507	VERB
biomedich-872	106	33	no	no	PRON
biomedich-872	106	34	0.328	0.328	NUM
biomedich-872	106	35	no	no	INTJ
biomedich-872	107	1	no	no	INTJ
biomedich-872	107	2	apigenin	apigenin	ADJ
biomedich-872	107	3	93.3	93.3	NUM
biomedich-872	107	4	-0.734	-0.734	NUM
biomedich-872	107	5	-2.061	-2.061	PUNCT
biomedich-872	107	6	no	no	INTJ
biomedich-872	107	7	0.566	0.566	NUM
biomedich-872	107	8	no	no	INTJ
biomedich-872	108	1	no	no	ADV
biomedich-872	108	2	based	base	VERB
biomedich-872	108	3	on	on	ADP
biomedich-872	108	4	admet	admet	PROPN
biomedich-872	108	5	prediction	prediction	NOUN
biomedich-872	108	6	using	use	VERB
biomedich-872	108	7	the	the	DET
biomedich-872	108	8	pkcms	pkcms	PROPN
biomedich-872	108	9	tool	tool	NOUN
biomedich-872	108	10	,	,	PUNCT
biomedich-872	108	11	most	most	ADJ
biomedich-872	108	12	compounds	compound	NOUN
biomedich-872	108	13	from	from	ADP
biomedich-872	108	14	physalis	physalis	NOUN
biomedich-872	108	15	angulata	angulata	NOUN
biomedich-872	108	16	showed	show	VERB
biomedich-872	108	17	good	good	ADJ
biomedich-872	108	18	intestinal	intestinal	ADJ
biomedich-872	108	19	absorption	absorption	NOUN
biomedich-872	108	20	,	,	PUNCT
biomedich-872	108	21	except	except	SCONJ
biomedich-872	108	22	for	for	ADP
biomedich-872	108	23	rhoifolin	rhoifolin	NOUN
biomedich-872	108	24	(	(	PUNCT
biomedich-872	108	25	24.3	24.3	NUM
biomedich-872	108	26	%	%	NOUN
biomedich-872	108	27	)	)	PUNCT
biomedich-872	108	28	and	and	CCONJ
biomedich-872	108	29	naringin	naringin	NOUN
biomedich-872	108	30	(	(	PUNCT
biomedich-872	108	31	25.8	25.8	NUM
biomedich-872	108	32	%	%	NOUN
biomedich-872	108	33	)	)	PUNCT
biomedich-872	108	34	,	,	PUNCT
biomedich-872	108	35	which	which	PRON
biomedich-872	108	36	fell	fall	VERB
biomedich-872	108	37	below	below	ADP
biomedich-872	108	38	the	the	DET
biomedich-872	108	39	30	30	NUM
biomedich-872	108	40	%	%	NOUN
biomedich-872	108	41	threshold	threshold	NOUN
biomedich-872	108	42	.	.	PUNCT
biomedich-872	109	1	tangeretin	tangeretin	PROPN
biomedich-872	109	2	exhibited	exhibit	VERB
biomedich-872	109	3	the	the	DET
biomedich-872	109	4	highest	high	ADJ
biomedich-872	109	5	absorption	absorption	NOUN
biomedich-872	109	6	rate	rate	NOUN
biomedich-872	109	7	(	(	PUNCT
biomedich-872	109	8	98.5	98.5	NUM
biomedich-872	109	9	%	%	NOUN
biomedich-872	109	10	)	)	PUNCT
biomedich-872	109	11	,	,	PUNCT
biomedich-872	109	12	followed	follow	VERB
biomedich-872	109	13	by	by	ADP
biomedich-872	109	14	apigenin	apigenin	PROPN
biomedich-872	109	15	(	(	PUNCT
biomedich-872	109	16	93.3	93.3	NUM
biomedich-872	109	17	%	%	NOUN
biomedich-872	109	18	)	)	PUNCT
biomedich-872	109	19	and	and	CCONJ
biomedich-872	109	20	kaempferol	kaempferol	NOUN
biomedich-872	109	21	(	(	PUNCT
biomedich-872	109	22	74.3	74.3	NUM
biomedich-872	109	23	%	%	NOUN
biomedich-872	109	24	)	)	PUNCT
biomedich-872	109	25	(	(	PUNCT
biomedich-872	109	26	ramadhan	ramadhan	PROPN
biomedich-872	109	27	et	et	PROPN
biomedich-872	109	28	al	al	PROPN
biomedich-872	109	29	.	.	PROPN
biomedich-872	109	30	,	,	PUNCT
biomedich-872	109	31	2024	2024	NUM
biomedich-872	109	32	)	)	PUNCT
biomedich-872	109	33	.	.	PUNCT
biomedich-872	110	1	all	all	DET
biomedich-872	110	2	ten	ten	NUM
biomedich-872	110	3	compounds	compound	NOUN
biomedich-872	110	4	were	be	AUX
biomedich-872	110	5	predicted	predict	VERB
biomedich-872	110	6	to	to	PART
biomedich-872	110	7	have	have	VERB
biomedich-872	110	8	poor	poor	ADJ
biomedich-872	110	9	blood	blood	NOUN
biomedich-872	110	10	–	–	PUNCT
biomedich-872	110	11	brain	brain	NOUN
biomedich-872	110	12	barrier	barrier	NOUN
biomedich-872	110	13	(	(	PUNCT
biomedich-872	110	14	bbb	bbb	NOUN
biomedich-872	110	15	)	)	PUNCT
biomedich-872	110	16	permeability	permeability	NOUN
biomedich-872	110	17	,	,	PUNCT
biomedich-872	110	18	with	with	ADP
biomedich-872	110	19	values	value	NOUN
biomedich-872	110	20	below	below	ADP
biomedich-872	110	21	-1	-1	ADV
biomedich-872	110	22	,	,	PUNCT
biomedich-872	110	23	particularly	particularly	ADV
biomedich-872	110	24	myricetrin	myricetrin	NOUN
biomedich-872	110	25	(	(	PUNCT
biomedich-872	110	26	-1.811	-1.811	PUNCT
biomedich-872	110	27	)	)	PUNCT
biomedich-872	110	28	and	and	CCONJ
biomedich-872	110	29	hesperidin	hesperidin	PROPN
biomedich-872	110	30	(	(	PUNCT
biomedich-872	110	31	-1.715	-1.715	NOUN
biomedich-872	110	32	)	)	PUNCT
biomedich-872	110	33	.	.	PUNCT
biomedich-872	111	1	only	only	ADV
biomedich-872	111	2	apigenin	apigenin	PROPN
biomedich-872	111	3	(	(	PUNCT
biomedich-872	111	4	-2.061	-2.061	PROPN
biomedich-872	111	5	)	)	PUNCT
biomedich-872	111	6	and	and	CCONJ
biomedich-872	111	7	kaempferol	kaempferol	NOUN
biomedich-872	111	8	(	(	PUNCT
biomedich-872	111	9	-2.228	-2.228	PROPN
biomedich-872	111	10	)	)	PUNCT
biomedich-872	111	11	approached	approach	VERB
biomedich-872	111	12	the	the	DET
biomedich-872	111	13	cns	cns	NOUN
biomedich-872	111	14	permeability	permeability	NOUN
biomedich-872	111	15	threshold	threshold	NOUN
biomedich-872	111	16	.	.	PUNCT
biomedich-872	112	1	none	none	NOUN
biomedich-872	112	2	of	of	ADP
biomedich-872	112	3	the	the	DET
biomedich-872	112	4	compounds	compound	NOUN
biomedich-872	112	5	were	be	AUX
biomedich-872	112	6	substrates	substrate	NOUN
biomedich-872	112	7	for	for	ADP
biomedich-872	112	8	cyp2d6	cyp2d6	NOUN
biomedich-872	112	9	or	or	CCONJ
biomedich-872	112	10	oct2	oct2	NOUN
biomedich-872	112	11	,	,	PUNCT
biomedich-872	112	12	while	while	SCONJ
biomedich-872	112	13	only	only	ADV
biomedich-872	112	14	tangeretin	tangeretin	ADJ
biomedich-872	112	15	was	be	AUX
biomedich-872	112	16	predicted	predict	VERB
biomedich-872	112	17	as	as	ADP
biomedich-872	112	18	a	a	DET
biomedich-872	112	19	cyp3a4	cyp3a4	NOUN
biomedich-872	112	20	substrate	substrate	NOUN
biomedich-872	112	21	.	.	PUNCT
biomedich-872	113	1	all	all	DET
biomedich-872	113	2	compounds	compound	NOUN
biomedich-872	113	3	were	be	AUX
biomedich-872	113	4	classified	classify	VERB
biomedich-872	113	5	as	as	ADP
biomedich-872	113	6	non	non	ADJ
biomedich-872	113	7	-	-	ADJ
biomedich-872	113	8	mutagenic	mutagenic	ADJ
biomedich-872	113	9	and	and	CCONJ
biomedich-872	113	10	nonhepatotoxic	nonhepatotoxic	ADJ
biomedich-872	113	11	.	.	PUNCT
biomedich-872	114	1	in	in	ADP
biomedich-872	114	2	terms	term	NOUN
biomedich-872	114	3	of	of	ADP
biomedich-872	114	4	clearance	clearance	NOUN
biomedich-872	114	5	,	,	PUNCT
biomedich-872	114	6	tangeretin	tangeretin	X
biomedich-872	114	7	(	(	PUNCT
biomedich-872	114	8	0.78	0.78	NUM
biomedich-872	114	9	log	log	NOUN
biomedich-872	114	10	ml	ml	NOUN
biomedich-872	114	11	/	/	SYM
biomedich-872	114	12	min	min	NOUN
biomedich-872	114	13	/	/	SYM
biomedich-872	114	14	kg	kg	NOUN
biomedich-872	114	15	)	)	PUNCT
biomedich-872	114	16	and	and	CCONJ
biomedich-872	114	17	apigenin	apigenin	PROPN
biomedich-872	114	18	(	(	PUNCT
biomedich-872	114	19	0.566	0.566	NUM
biomedich-872	114	20	)	)	PUNCT
biomedich-872	114	21	had	have	AUX
biomedich-872	114	22	the	the	DET
biomedich-872	114	23	highest	high	ADJ
biomedich-872	114	24	predicted	predict	VERB
biomedich-872	114	25	elimination	elimination	NOUN
biomedich-872	114	26	rates	rate	NOUN
biomedich-872	114	27	(	(	PUNCT
biomedich-872	114	28	utami	utami	NOUN
biomedich-872	114	29	et	et	PROPN
biomedich-872	114	30	al	al	PROPN
biomedich-872	114	31	.	.	PROPN
biomedich-872	114	32	,	,	PUNCT
biomedich-872	114	33	2025	2025	NUM
biomedich-872	114	34	)	)	PUNCT
biomedich-872	114	35	.	.	PUNCT
biomedich-872	115	1	discussion	discussion	NOUN
biomedich-872	115	2	the	the	DET
biomedich-872	115	3	results	result	NOUN
biomedich-872	115	4	of	of	ADP
biomedich-872	115	5	the	the	DET
biomedich-872	115	6	docking	docking	NOUN
biomedich-872	115	7	analysis	analysis	NOUN
biomedich-872	115	8	provide	provide	VERB
biomedich-872	115	9	insight	insight	NOUN
biomedich-872	115	10	into	into	ADP
biomedich-872	115	11	the	the	DET
biomedich-872	115	12	molecular	molecular	ADJ
biomedich-872	115	13	interactions	interaction	NOUN
biomedich-872	115	14	between	between	ADP
biomedich-872	115	15	active	active	ADJ
biomedich-872	115	16	compounds	compound	NOUN
biomedich-872	115	17	from	from	ADP
biomedich-872	115	18	physalis	physalis	NOUN
biomedich-872	115	19	angulata	angulata	ADJ
biomedich-872	115	20	and	and	CCONJ
biomedich-872	115	21	the	the	DET
biomedich-872	115	22	pi3k	pi3k	PROPN
biomedich-872	115	23	/	/	SYM
biomedich-872	115	24	akt	akt	PROPN
biomedich-872	115	25	protein	protein	NOUN
biomedich-872	115	26	,	,	PUNCT
biomedich-872	115	27	a	a	DET
biomedich-872	115	28	critical	critical	ADJ
biomedich-872	115	29	signalling	signal	VERB
biomedich-872	115	30	pathway	pathway	NOUN
biomedich-872	115	31	implicated	implicate	VERB
biomedich-872	115	32	in	in	ADP
biomedich-872	115	33	fibrosis	fibrosis	NOUN
biomedich-872	115	34	progression	progression	NOUN
biomedich-872	115	35	.	.	PUNCT
biomedich-872	116	1	the	the	DET
biomedich-872	116	2	high	high	ADJ
biomedich-872	116	3	binding	bind	VERB
biomedich-872	116	4	affinity	affinity	NOUN
biomedich-872	116	5	observed	observe	VERB
biomedich-872	116	6	in	in	ADP
biomedich-872	116	7	compounds	compound	NOUN
biomedich-872	116	8	like	like	ADP
biomedich-872	116	9	myricetrin	myricetrin	NOUN
biomedich-872	116	10	and	and	CCONJ
biomedich-872	116	11	eriodictyol	eriodictyol	NOUN
biomedich-872	116	12	suggests	suggest	VERB
biomedich-872	116	13	a	a	DET
biomedich-872	116	14	strong	strong	ADJ
biomedich-872	116	15	and	and	CCONJ
biomedich-872	116	16	potentially	potentially	ADV
biomedich-872	116	17	biologically	biologically	ADV
biomedich-872	116	18	relevant	relevant	ADJ
biomedich-872	116	19	interaction	interaction	NOUN
biomedich-872	116	20	,	,	PUNCT
biomedich-872	116	21	comparable	comparable	ADJ
biomedich-872	116	22	or	or	CCONJ
biomedich-872	116	23	even	even	ADV
biomedich-872	116	24	superior	superior	ADJ
biomedich-872	116	25	to	to	ADP
biomedich-872	116	26	the	the	DET
biomedich-872	116	27	native	native	ADJ
biomedich-872	116	28	ligand	ligand	NOUN
biomedich-872	116	29	.	.	PUNCT
biomedich-872	117	1	these	these	DET
biomedich-872	117	2	findings	finding	NOUN
biomedich-872	117	3	support	support	VERB
biomedich-872	117	4	the	the	DET
biomedich-872	117	5	hypothesis	hypothesis	NOUN
biomedich-872	117	6	that	that	PRON
biomedich-872	117	7	certain	certain	ADJ
biomedich-872	117	8	flavonoids	flavonoid	NOUN
biomedich-872	117	9	may	may	AUX
biomedich-872	117	10	inhibit	inhibit	VERB
biomedich-872	117	11	pi3k	pi3k	PROPN
biomedich-872	117	12	/	/	SYM
biomedich-872	117	13	akt	akt	PROPN
biomedich-872	117	14	activity	activity	NOUN
biomedich-872	117	15	and	and	CCONJ
biomedich-872	117	16	thus	thus	ADV
biomedich-872	117	17	interfere	interfere	VERB
biomedich-872	117	18	with	with	ADP
biomedich-872	117	19	fibrotic	fibrotic	ADJ
biomedich-872	117	20	signalling	signal	VERB
biomedich-872	117	21	mechanisms	mechanism	NOUN
biomedich-872	117	22	.	.	PUNCT
biomedich-872	118	1	farid	farid	PROPN
biomedich-872	118	2	et	et	PROPN
biomedich-872	118	3	al	al	PROPN
biomedich-872	118	4	.	.	PROPN
biomedich-872	118	5	–	–	PUNCT
biomedich-872	118	6	predicting	predict	VERB
biomedich-872	118	7	the	the	DET
biomedich-872	118	8	anti	anti	ADJ
biomedich-872	118	9	-	-	ADJ
biomedich-872	118	10	pulmonary	pulmonary	ADJ
biomedich-872	118	11	fibrosis	fibrosis	NOUN
biomedich-872	118	12	potential	potential	NOUN
biomedich-872	118	13	…	…	PUNCT
biomedich-872	118	14	821	821	NUM
biomedich-872	118	15	figure	figure	NOUN
biomedich-872	118	16	2	2	NUM
biomedich-872	118	17	.	.	PUNCT
biomedich-872	118	18	3d	3d	NUM
biomedich-872	118	19	structure	structure	NOUN
biomedich-872	118	20	of	of	ADP
biomedich-872	118	21	pi3k	pi3k	PROPN
biomedich-872	118	22	/	/	SYM
biomedich-872	118	23	akt	akt	PROPN
biomedich-872	118	24	protein	protein	NOUN
biomedich-872	118	25	(	(	PUNCT
biomedich-872	118	26	pdb	pdb	PROPN
biomedich-872	118	27	i	i	NOUN
biomedich-872	118	28	d	d	PROPN
biomedich-872	118	29	:	:	PUNCT
biomedich-872	118	30	2uzt	2uzt	NUM
biomedich-872	118	31	)	)	PUNCT
biomedich-872	118	32	with	with	ADP
biomedich-872	118	33	binding	bind	VERB
biomedich-872	118	34	site	site	NOUN
biomedich-872	118	35	.	.	PUNCT
biomedich-872	119	1	the	the	DET
biomedich-872	119	2	frequent	frequent	ADJ
biomedich-872	119	3	appearance	appearance	NOUN
biomedich-872	119	4	of	of	ADP
biomedich-872	119	5	val57	val57	PROPN
biomedich-872	119	6	,	,	PUNCT
biomedich-872	119	7	leu173	leu173	PROPN
biomedich-872	119	8	,	,	PUNCT
biomedich-872	119	9	and	and	CCONJ
biomedich-872	119	10	ala70	ala70	PROPN
biomedich-872	119	11	in	in	ADP
biomedich-872	119	12	non	non	ADJ
biomedich-872	119	13	-	-	ADJ
biomedich-872	119	14	polar	polar	ADJ
biomedich-872	119	15	interactions	interaction	NOUN
biomedich-872	119	16	implies	imply	VERB
biomedich-872	119	17	the	the	DET
biomedich-872	119	18	presence	presence	NOUN
biomedich-872	119	19	of	of	ADP
biomedich-872	119	20	a	a	DET
biomedich-872	119	21	conserved	conserve	VERB
biomedich-872	119	22	hydrophobic	hydrophobic	NOUN
biomedich-872	119	23	pocket	pocket	NOUN
biomedich-872	119	24	that	that	PRON
biomedich-872	119	25	stabilizes	stabilize	VERB
biomedich-872	119	26	the	the	DET
biomedich-872	119	27	ligand	ligand	NOUN
biomedich-872	119	28	through	through	ADP
biomedich-872	119	29	van	van	PROPN
biomedich-872	119	30	der	der	ADJ
biomedich-872	119	31	waals	waal	NOUN
biomedich-872	119	32	and	and	CCONJ
biomedich-872	119	33	hydrophobic	hydrophobic	NOUN
biomedich-872	119	34	interactions	interaction	NOUN
biomedich-872	119	35	.	.	PUNCT
biomedich-872	120	1	this	this	DET
biomedich-872	120	2	structural	structural	ADJ
biomedich-872	120	3	feature	feature	NOUN
biomedich-872	120	4	may	may	AUX
biomedich-872	120	5	contribute	contribute	VERB
biomedich-872	120	6	significantly	significantly	ADV
biomedich-872	120	7	to	to	ADP
biomedich-872	120	8	the	the	DET
biomedich-872	120	9	overall	overall	ADJ
biomedich-872	120	10	binding	bind	VERB
biomedich-872	120	11	strength	strength	NOUN
biomedich-872	120	12	of	of	ADP
biomedich-872	120	13	the	the	DET
biomedich-872	120	14	tested	test	VERB
biomedich-872	120	15	ligands	ligand	NOUN
biomedich-872	120	16	.	.	PUNCT
biomedich-872	121	1	moreover	moreover	ADV
biomedich-872	121	2	,	,	PUNCT
biomedich-872	121	3	the	the	DET
biomedich-872	121	4	consistent	consistent	ADJ
biomedich-872	121	5	involvement	involvement	NOUN
biomedich-872	121	6	of	of	ADP
biomedich-872	121	7	polar	polar	ADJ
biomedich-872	121	8	residues	residue	NOUN
biomedich-872	121	9	such	such	ADJ
biomedich-872	121	10	as	as	ADP
biomedich-872	121	11	asp184	asp184	PROPN
biomedich-872	121	12	and	and	CCONJ
biomedich-872	121	13	glu121	glu121	NOUN
biomedich-872	121	14	in	in	ADP
biomedich-872	121	15	hydrogen	hydrogen	NOUN
biomedich-872	121	16	bonding	bonding	NOUN
biomedich-872	121	17	highlights	highlight	NOUN
biomedich-872	121	18	their	their	PRON
biomedich-872	121	19	central	central	ADJ
biomedich-872	121	20	role	role	NOUN
biomedich-872	121	21	in	in	ADP
biomedich-872	121	22	mediating	mediate	VERB
biomedich-872	121	23	strong	strong	ADJ
biomedich-872	121	24	and	and	CCONJ
biomedich-872	121	25	specific	specific	ADJ
biomedich-872	121	26	ligandreceptor	ligandreceptor	NOUN
biomedich-872	121	27	interactions	interaction	NOUN
biomedich-872	121	28	.	.	PUNCT
biomedich-872	122	1	asp184	asp184	NOUN
biomedich-872	122	2	’s	’s	PART
biomedich-872	122	3	ability	ability	NOUN
biomedich-872	122	4	to	to	PART
biomedich-872	122	5	act	act	VERB
biomedich-872	122	6	as	as	SCONJ
biomedich-872	122	7	both	both	CCONJ
biomedich-872	122	8	a	a	DET
biomedich-872	122	9	donor	donor	NOUN
biomedich-872	122	10	and	and	CCONJ
biomedich-872	122	11	acceptor	acceptor	NOUN
biomedich-872	122	12	enhances	enhance	VERB
biomedich-872	122	13	its	its	PRON
biomedich-872	122	14	versatility	versatility	NOUN
biomedich-872	122	15	and	and	CCONJ
biomedich-872	122	16	reactivity	reactivity	NOUN
biomedich-872	122	17	,	,	PUNCT
biomedich-872	122	18	potentially	potentially	ADV
biomedich-872	122	19	serving	serve	VERB
biomedich-872	122	20	as	as	ADP
biomedich-872	122	21	a	a	DET
biomedich-872	122	22	critical	critical	ADJ
biomedich-872	122	23	anchor	anchor	NOUN
biomedich-872	122	24	point	point	NOUN
biomedich-872	122	25	in	in	ADP
biomedich-872	122	26	the	the	DET
biomedich-872	122	27	binding	bind	VERB
biomedich-872	122	28	site	site	NOUN
biomedich-872	122	29	.	.	PUNCT
biomedich-872	123	1	figure	figure	VERB
biomedich-872	123	2	3	3	NUM
biomedich-872	123	3	.	.	PUNCT
biomedich-872	124	1	binding	bind	VERB
biomedich-872	124	2	pocket	pocket	NOUN
biomedich-872	124	3	interactions	interaction	NOUN
biomedich-872	124	4	of	of	ADP
biomedich-872	124	5	(	(	PUNCT
biomedich-872	124	6	a	a	PRON
biomedich-872	124	7	)	)	PUNCT
biomedich-872	124	8	myricetrin	myricetrin	NOUN
biomedich-872	124	9	,	,	PUNCT
biomedich-872	124	10	(	(	PUNCT
biomedich-872	124	11	b	b	X
biomedich-872	124	12	)	)	PUNCT
biomedich-872	124	13	eriodictyol	eriodictyol	NOUN
biomedich-872	124	14	,	,	PUNCT
biomedich-872	124	15	(	(	PUNCT
biomedich-872	124	16	c	c	NOUN
biomedich-872	124	17	)	)	PUNCT
biomedich-872	124	18	naringin	naringin	NOUN
biomedich-872	124	19	,	,	PUNCT
biomedich-872	124	20	and	and	CCONJ
biomedich-872	124	21	(	(	PUNCT
biomedich-872	124	22	d	d	X
biomedich-872	124	23	)	)	PUNCT
biomedich-872	124	24	epigallocatechin	epigallocatechin	NOUN
biomedich-872	124	25	with	with	ADP
biomedich-872	124	26	akt	akt	PROPN
biomedich-872	124	27	.	.	PUNCT
biomedich-872	125	1	822	822	NUM
biomedich-872	125	2	biology	biology	NOUN
biomedich-872	125	3	,	,	PUNCT
biomedich-872	125	4	medicine	medicine	NOUN
biomedich-872	125	5	,	,	PUNCT
biomedich-872	125	6	&	&	CCONJ
biomedich-872	125	7	natural	natural	ADJ
biomedich-872	125	8	product	product	NOUN
biomedich-872	125	9	chemistry	chemistry	NOUN
biomedich-872	125	10	14	14	NUM
biomedich-872	125	11	(	(	PUNCT
biomedich-872	125	12	2	2	NUM
biomedich-872	125	13	)	)	PUNCT
biomedich-872	125	14	,	,	PUNCT
biomedich-872	125	15	2025	2025	NUM
biomedich-872	125	16	:	:	PUNCT
biomedich-872	125	17	817	817	NUM
biomedich-872	125	18	-	-	SYM
biomedich-872	125	19	824	824	NUM
biomedich-872	125	20	the	the	DET
biomedich-872	125	21	results	result	NOUN
biomedich-872	125	22	suggest	suggest	VERB
biomedich-872	125	23	that	that	SCONJ
biomedich-872	125	24	bioactive	bioactive	VERB
biomedich-872	125	25	compounds	compound	NOUN
biomedich-872	125	26	from	from	ADP
biomedich-872	125	27	physalis	physalis	NOUN
biomedich-872	125	28	angulata	angulata	NOUN
biomedich-872	125	29	may	may	AUX
biomedich-872	125	30	have	have	VERB
biomedich-872	125	31	therapeutic	therapeutic	ADJ
biomedich-872	125	32	potential	potential	NOUN
biomedich-872	125	33	for	for	ADP
biomedich-872	125	34	pulmonary	pulmonary	ADJ
biomedich-872	125	35	fibrosis	fibrosis	NOUN
biomedich-872	125	36	by	by	ADP
biomedich-872	125	37	targeting	target	VERB
biomedich-872	125	38	pathways	pathway	NOUN
biomedich-872	125	39	shared	share	VERB
biomedich-872	125	40	with	with	ADP
biomedich-872	125	41	lung	lung	NOUN
biomedich-872	125	42	cancer	cancer	NOUN
biomedich-872	125	43	,	,	PUNCT
biomedich-872	125	44	such	such	ADJ
biomedich-872	125	45	as	as	ADP
biomedich-872	125	46	fibroblast	fibroblast	ADJ
biomedich-872	125	47	proliferation	proliferation	NOUN
biomedich-872	125	48	and	and	CCONJ
biomedich-872	125	49	extracellular	extracellular	ADJ
biomedich-872	125	50	matrix	matrix	NOUN
biomedich-872	125	51	accumulation	accumulation	NOUN
biomedich-872	125	52	through	through	ADP
biomedich-872	125	53	modulation	modulation	NOUN
biomedich-872	125	54	of	of	ADP
biomedich-872	125	55	tgf	tgf	PROPN
biomedich-872	125	56	-	-	PUNCT
biomedich-872	125	57	β	β	NOUN
biomedich-872	125	58	/	/	SYM
biomedich-872	125	59	smad	smad	PROPN
biomedich-872	125	60	and	and	CCONJ
biomedich-872	125	61	nf	nf	NOUN
biomedich-872	125	62	-	-	PUNCT
biomedich-872	125	63	κb	κb	NOUN
biomedich-872	125	64	signalling	signal	VERB
biomedich-872	125	65	(	(	PUNCT
biomedich-872	125	66	fan	fan	NOUN
biomedich-872	125	67	et	et	PROPN
biomedich-872	125	68	al	al	PROPN
biomedich-872	125	69	.	.	PROPN
biomedich-872	125	70	,	,	PUNCT
biomedich-872	125	71	2023	2023	NUM
biomedich-872	125	72	)	)	PUNCT
biomedich-872	125	73	.	.	PUNCT
biomedich-872	126	1	compounds	compound	NOUN
biomedich-872	126	2	like	like	ADP
biomedich-872	126	3	myricetrin	myricetrin	NOUN
biomedich-872	126	4	and	and	CCONJ
biomedich-872	126	5	rhoifolin	rhoifolin	NOUN
biomedich-872	126	6	showed	show	VERB
biomedich-872	126	7	high	high	ADJ
biomedich-872	126	8	predictive	predictive	ADJ
biomedich-872	126	9	activity	activity	NOUN
biomedich-872	126	10	values	value	NOUN
biomedich-872	126	11	,	,	PUNCT
biomedich-872	126	12	indicating	indicate	VERB
biomedich-872	126	13	strong	strong	ADJ
biomedich-872	126	14	antifibrotic	antifibrotic	ADJ
biomedich-872	126	15	potential	potential	NOUN
biomedich-872	126	16	,	,	PUNCT
biomedich-872	126	17	while	while	SCONJ
biomedich-872	126	18	apigenin	apigenin	ADJ
biomedich-872	126	19	and	and	CCONJ
biomedich-872	126	20	kaempferol	kaempferol	NOUN
biomedich-872	126	21	,	,	PUNCT
biomedich-872	126	22	despite	despite	SCONJ
biomedich-872	126	23	slightly	slightly	ADV
biomedich-872	126	24	lower	low	ADJ
biomedich-872	126	25	scores	score	NOUN
biomedich-872	126	26	,	,	PUNCT
biomedich-872	126	27	have	have	AUX
biomedich-872	126	28	been	be	AUX
biomedich-872	126	29	shown	show	VERB
biomedich-872	126	30	to	to	PART
biomedich-872	126	31	suppress	suppress	VERB
biomedich-872	126	32	key	key	ADJ
biomedich-872	126	33	fibrosis	fibrosis	NOUN
biomedich-872	126	34	markers	marker	NOUN
biomedich-872	126	35	such	such	ADJ
biomedich-872	126	36	as	as	ADP
biomedich-872	126	37	α	α	NOUN
biomedich-872	126	38	-	-	PUNCT
biomedich-872	126	39	sma	sma	NOUN
biomedich-872	126	40	and	and	CCONJ
biomedich-872	126	41	fibronectin	fibronectin	NOUN
biomedich-872	126	42	(	(	PUNCT
biomedich-872	126	43	b.	b.	PROPN
biomedich-872	126	44	ke	ke	PROPN
biomedich-872	126	45	et	et	PROPN
biomedich-872	126	46	al	al	PROPN
biomedich-872	126	47	.	.	PROPN
biomedich-872	126	48	,	,	PUNCT
biomedich-872	126	49	2018	2018	NUM
biomedich-872	126	50	)	)	PUNCT
biomedich-872	126	51	.	.	PUNCT
biomedich-872	127	1	hesperidin	hesperidin	VERB
biomedich-872	127	2	and	and	CCONJ
biomedich-872	127	3	tangeretin	tangeretin	PROPN
biomedich-872	127	4	also	also	ADV
biomedich-872	127	5	demonstrated	demonstrate	VERB
biomedich-872	127	6	promising	promise	VERB
biomedich-872	127	7	anti	anti	ADJ
biomedich-872	127	8	-	-	ADJ
biomedich-872	127	9	inflammatory	inflammatory	ADJ
biomedich-872	127	10	and	and	CCONJ
biomedich-872	127	11	antiproliferative	antiproliferative	ADJ
biomedich-872	127	12	effects	effect	NOUN
biomedich-872	127	13	that	that	PRON
biomedich-872	127	14	may	may	AUX
biomedich-872	127	15	slow	slow	VERB
biomedich-872	127	16	fibrosis	fibrosis	NOUN
biomedich-872	127	17	progression	progression	NOUN
biomedich-872	127	18	(	(	PUNCT
biomedich-872	127	19	fan	fan	NOUN
biomedich-872	127	20	et	et	PROPN
biomedich-872	127	21	al	al	PROPN
biomedich-872	127	22	.	.	PROPN
biomedich-872	127	23	,	,	PUNCT
biomedich-872	127	24	2023	2023	NUM
biomedich-872	127	25	)	)	PUNCT
biomedich-872	127	26	.	.	PUNCT
biomedich-872	128	1	the	the	DET
biomedich-872	128	2	overlap	overlap	NOUN
biomedich-872	128	3	between	between	ADP
biomedich-872	128	4	antifibrotic	antifibrotic	ADJ
biomedich-872	128	5	and	and	CCONJ
biomedich-872	128	6	antineoplastic	antineoplastic	ADJ
biomedich-872	128	7	activities	activity	NOUN
biomedich-872	128	8	highlights	highlight	VERB
biomedich-872	128	9	the	the	DET
biomedich-872	128	10	molecular	molecular	ADJ
biomedich-872	128	11	parallels	parallel	NOUN
biomedich-872	128	12	between	between	ADP
biomedich-872	128	13	fibrosis	fibrosis	NOUN
biomedich-872	128	14	and	and	CCONJ
biomedich-872	128	15	cancer	cancer	NOUN
biomedich-872	128	16	,	,	PUNCT
biomedich-872	128	17	especially	especially	ADV
biomedich-872	128	18	involving	involve	VERB
biomedich-872	128	19	emt	emt	NOUN
biomedich-872	128	20	and	and	CCONJ
biomedich-872	128	21	abnormal	abnormal	ADJ
biomedich-872	128	22	cell	cell	NOUN
biomedich-872	128	23	growth	growth	NOUN
biomedich-872	128	24	(	(	PUNCT
biomedich-872	128	25	vithalkar	vithalkar	NOUN
biomedich-872	128	26	et	et	PROPN
biomedich-872	128	27	al	al	PROPN
biomedich-872	128	28	.	.	PROPN
biomedich-872	128	29	,	,	PUNCT
biomedich-872	128	30	2025	2025	NUM
biomedich-872	128	31	)	)	PUNCT
biomedich-872	128	32	.	.	PUNCT
biomedich-872	129	1	this	this	PRON
biomedich-872	129	2	supports	support	VERB
biomedich-872	129	3	the	the	DET
biomedich-872	129	4	use	use	NOUN
biomedich-872	129	5	of	of	ADP
biomedich-872	129	6	network	network	NOUN
biomedich-872	129	7	pharmacology	pharmacology	NOUN
biomedich-872	129	8	as	as	ADP
biomedich-872	129	9	a	a	DET
biomedich-872	129	10	useful	useful	ADJ
biomedich-872	129	11	approach	approach	NOUN
biomedich-872	129	12	to	to	PART
biomedich-872	129	13	explore	explore	VERB
biomedich-872	129	14	multi	multi	ADJ
biomedich-872	129	15	-	-	NOUN
biomedich-872	129	16	target	target	ADJ
biomedich-872	129	17	and	and	CCONJ
biomedich-872	129	18	multi	multi	ADJ
biomedich-872	129	19	-	-	ADJ
biomedich-872	129	20	component	component	ADJ
biomedich-872	129	21	therapies	therapy	NOUN
biomedich-872	129	22	,	,	PUNCT
biomedich-872	129	23	which	which	PRON
biomedich-872	129	24	are	be	AUX
biomedich-872	129	25	better	well	ADV
biomedich-872	129	26	suited	suit	VERB
biomedich-872	129	27	for	for	ADP
biomedich-872	129	28	complex	complex	ADJ
biomedich-872	129	29	diseases	disease	NOUN
biomedich-872	129	30	like	like	ADP
biomedich-872	129	31	pulmonary	pulmonary	ADJ
biomedich-872	129	32	fibrosis	fibrosis	NOUN
biomedich-872	129	33	where	where	SCONJ
biomedich-872	129	34	single	single	ADJ
biomedich-872	129	35	-	-	PUNCT
biomedich-872	129	36	target	target	NOUN
biomedich-872	129	37	drugs	drug	NOUN
biomedich-872	129	38	often	often	ADV
biomedich-872	129	39	fall	fall	VERB
biomedich-872	129	40	short	short	ADJ
biomedich-872	129	41	(	(	PUNCT
biomedich-872	129	42	liu	liu	PROPN
biomedich-872	129	43	et	et	PROPN
biomedich-872	129	44	al	al	PROPN
biomedich-872	129	45	.	.	PROPN
biomedich-872	129	46	,	,	PUNCT
biomedich-872	129	47	2021	2021	NUM
biomedich-872	129	48	;	;	PUNCT
biomedich-872	129	49	nogales	nogale	NOUN
biomedich-872	129	50	et	et	PROPN
biomedich-872	129	51	al	al	PROPN
biomedich-872	129	52	.	.	PROPN
biomedich-872	129	53	,	,	PUNCT
biomedich-872	129	54	2022	2022	NUM
biomedich-872	129	55	)	)	PUNCT
biomedich-872	129	56	.	.	PUNCT
biomedich-872	130	1	consequently	consequently	ADV
biomedich-872	130	2	,	,	PUNCT
biomedich-872	130	3	myricetrin	myricetrin	NOUN
biomedich-872	130	4	,	,	PUNCT
biomedich-872	130	5	rhoifolin	rhoifolin	NOUN
biomedich-872	130	6	,	,	PUNCT
biomedich-872	130	7	and	and	CCONJ
biomedich-872	130	8	kaempferol	kaempferol	NOUN
biomedich-872	130	9	emerge	emerge	VERB
biomedich-872	130	10	as	as	ADP
biomedich-872	130	11	promising	promise	VERB
biomedich-872	130	12	candidates	candidate	NOUN
biomedich-872	130	13	for	for	ADP
biomedich-872	130	14	further	further	ADJ
biomedich-872	130	15	research	research	NOUN
biomedich-872	130	16	and	and	CCONJ
biomedich-872	130	17	development	development	NOUN
biomedich-872	130	18	as	as	ADP
biomedich-872	130	19	natural	natural	ADJ
biomedich-872	130	20	anti	anti	ADJ
biomedich-872	130	21	-	-	ADJ
biomedich-872	130	22	fibrotic	fibrotic	ADJ
biomedich-872	130	23	agents	agent	NOUN
biomedich-872	130	24	(	(	PUNCT
biomedich-872	130	25	h.	h.	PROPN
biomedich-872	130	26	l.	l.	PROPN
biomedich-872	130	27	ke	ke	PROPN
biomedich-872	130	28	et	et	PROPN
biomedich-872	130	29	al	al	PROPN
biomedich-872	130	30	.	.	PROPN
biomedich-872	130	31	,	,	PUNCT
biomedich-872	130	32	2024	2024	NUM
biomedich-872	130	33	)	)	PUNCT
biomedich-872	130	34	.	.	PUNCT
biomedich-872	131	1	multiple	multiple	ADJ
biomedich-872	131	2	in	in	ADP
biomedich-872	131	3	vivo	vivo	NOUN
biomedich-872	131	4	and	and	CCONJ
biomedich-872	131	5	in	in	ADP
biomedich-872	131	6	vitro	vitro	X
biomedich-872	131	7	studies	study	NOUN
biomedich-872	131	8	have	have	AUX
biomedich-872	131	9	consistently	consistently	ADV
biomedich-872	131	10	demonstrated	demonstrate	VERB
biomedich-872	131	11	the	the	DET
biomedich-872	131	12	antifibrotic	antifibrotic	ADJ
biomedich-872	131	13	potential	potential	NOUN
biomedich-872	131	14	of	of	ADP
biomedich-872	131	15	physalis	physalis	NOUN
biomedich-872	131	16	angulata	angulata	ADJ
biomedich-872	131	17	(	(	PUNCT
biomedich-872	131	18	ciplukan	ciplukan	NOUN
biomedich-872	131	19	)	)	PUNCT
biomedich-872	131	20	,	,	PUNCT
biomedich-872	131	21	supporting	support	VERB
biomedich-872	131	22	the	the	DET
biomedich-872	131	23	molecular	molecular	ADJ
biomedich-872	131	24	docking	docking	NOUN
biomedich-872	131	25	results	result	NOUN
biomedich-872	131	26	presented	present	VERB
biomedich-872	131	27	in	in	ADP
biomedich-872	131	28	this	this	DET
biomedich-872	131	29	study	study	NOUN
biomedich-872	131	30	.	.	PUNCT
biomedich-872	132	1	wiraswati	wiraswati	PROPN
biomedich-872	132	2	et	et	PROPN
biomedich-872	132	3	al	al	PROPN
biomedich-872	132	4	.	.	PROPN
biomedich-872	133	1	(	(	PUNCT
biomedich-872	133	2	2024	2024	NUM
biomedich-872	133	3	)	)	PUNCT
biomedich-872	133	4	reported	report	VERB
biomedich-872	133	5	that	that	SCONJ
biomedich-872	133	6	ethanol	ethanol	NOUN
biomedich-872	133	7	extract	extract	NOUN
biomedich-872	133	8	of	of	ADP
biomedich-872	133	9	p.	p.	NOUN
biomedich-872	133	10	angulata	angulata	NOUN
biomedich-872	133	11	significantly	significantly	ADV
biomedich-872	133	12	reduced	reduce	VERB
biomedich-872	133	13	fibrosis	fibrosis	NOUN
biomedich-872	133	14	scores	score	NOUN
biomedich-872	133	15	and	and	CCONJ
biomedich-872	133	16	serum	serum	NOUN
biomedich-872	133	17	levels	level	NOUN
biomedich-872	133	18	of	of	ADP
biomedich-872	133	19	il-6	il-6	NUM
biomedich-872	133	20	,	,	PUNCT
biomedich-872	133	21	tgfβ1	tgfβ1	PROPN
biomedich-872	133	22	,	,	PUNCT
biomedich-872	133	23	and	and	CCONJ
biomedich-872	133	24	kl-6	kl-6	NOUN
biomedich-872	133	25	in	in	ADP
biomedich-872	133	26	a	a	DET
biomedich-872	133	27	bleomycin	bleomycin	NOUN
biomedich-872	133	28	-	-	PUNCT
biomedich-872	133	29	induced	induce	VERB
biomedich-872	133	30	pulmonary	pulmonary	ADJ
biomedich-872	133	31	fibrosis	fibrosis	NOUN
biomedich-872	133	32	mouse	mouse	NOUN
biomedich-872	133	33	model	model	NOUN
biomedich-872	133	34	.	.	PUNCT
biomedich-872	134	1	these	these	DET
biomedich-872	134	2	biological	biological	ADJ
biomedich-872	134	3	outcomes	outcome	NOUN
biomedich-872	134	4	are	be	AUX
biomedich-872	134	5	consistent	consistent	ADJ
biomedich-872	134	6	with	with	ADP
biomedich-872	134	7	the	the	DET
biomedich-872	134	8	docking	docking	NOUN
biomedich-872	134	9	findings	finding	NOUN
biomedich-872	134	10	,	,	PUNCT
biomedich-872	134	11	where	where	SCONJ
biomedich-872	134	12	flavonoid	flavonoid	PROPN
biomedich-872	134	13	compounds	compound	VERB
biomedich-872	134	14	such	such	ADJ
biomedich-872	134	15	as	as	ADP
biomedich-872	134	16	myricetrin	myricetrin	NOUN
biomedich-872	134	17	,	,	PUNCT
biomedich-872	134	18	eriodictyol	eriodictyol	NOUN
biomedich-872	134	19	,	,	PUNCT
biomedich-872	134	20	and	and	CCONJ
biomedich-872	134	21	hesperidin	hesperidin	PROPN
biomedich-872	134	22	exhibited	exhibit	VERB
biomedich-872	134	23	strong	strong	ADJ
biomedich-872	134	24	binding	bind	VERB
biomedich-872	134	25	affinities	affinity	NOUN
biomedich-872	134	26	and	and	CCONJ
biomedich-872	134	27	interacted	interact	VERB
biomedich-872	134	28	with	with	ADP
biomedich-872	134	29	key	key	ADJ
biomedich-872	134	30	residues	residue	NOUN
biomedich-872	134	31	including	include	VERB
biomedich-872	134	32	asp184	asp184	PROPN
biomedich-872	134	33	,	,	PUNCT
biomedich-872	134	34	glu121	glu121	NOUN
biomedich-872	134	35	,	,	PUNCT
biomedich-872	134	36	and	and	CCONJ
biomedich-872	134	37	lys72	lys72	NOUN
biomedich-872	134	38	associated	associate	VERB
biomedich-872	134	39	with	with	ADP
biomedich-872	134	40	fibrotic	fibrotic	ADJ
biomedich-872	134	41	and	and	CCONJ
biomedich-872	134	42	inflammatory	inflammatory	ADJ
biomedich-872	134	43	pathways	pathway	NOUN
biomedich-872	134	44	.	.	PUNCT
biomedich-872	135	1	a	a	DET
biomedich-872	135	2	fibroblast	fibroblast	ADJ
biomedich-872	135	3	model	model	NOUN
biomedich-872	135	4	confirmed	confirm	VERB
biomedich-872	135	5	that	that	SCONJ
biomedich-872	135	6	p.	p.	NOUN
biomedich-872	135	7	angulata	angulata	ADJ
biomedich-872	135	8	ethanol	ethanol	NOUN
biomedich-872	135	9	extract	extract	NOUN
biomedich-872	135	10	inhibited	inhibit	VERB
biomedich-872	135	11	cell	cell	NOUN
biomedich-872	135	12	migration	migration	NOUN
biomedich-872	135	13	and	and	CCONJ
biomedich-872	135	14	downregulated	downregulate	VERB
biomedich-872	135	15	il-6	il-6	NOUN
biomedich-872	135	16	and	and	CCONJ
biomedich-872	135	17	hif-1α	hif-1α	NOUN
biomedich-872	135	18	expression	expression	NOUN
biomedich-872	135	19	in	in	ADP
biomedich-872	135	20	tgf	tgf	PROPN
biomedich-872	135	21	-	-	PUNCT
biomedich-872	135	22	β	β	NOUN
biomedich-872	135	23	-	-	VERB
biomedich-872	135	24	induced	induce	VERB
biomedich-872	135	25	3t3	3t3	NUM
biomedich-872	135	26	-	-	PUNCT
biomedich-872	135	27	l1	l1	NOUN
biomedich-872	135	28	cells	cell	NOUN
biomedich-872	135	29	,	,	PUNCT
biomedich-872	135	30	which	which	PRON
biomedich-872	135	31	supports	support	VERB
biomedich-872	135	32	the	the	DET
biomedich-872	135	33	proposed	propose	VERB
biomedich-872	135	34	anti	anti	ADJ
biomedich-872	135	35	-	-	ADJ
biomedich-872	135	36	inflammatory	inflammatory	ADJ
biomedich-872	135	37	and	and	CCONJ
biomedich-872	135	38	antifibrogenic	antifibrogenic	ADJ
biomedich-872	135	39	mechanism	mechanism	NOUN
biomedich-872	135	40	of	of	ADP
biomedich-872	135	41	the	the	DET
biomedich-872	135	42	docked	docked	ADJ
biomedich-872	135	43	ligands	ligand	NOUN
biomedich-872	135	44	(	(	PUNCT
biomedich-872	135	45	rohmawaty	rohmawaty	NOUN
biomedich-872	135	46	et	et	PROPN
biomedich-872	135	47	al	al	PROPN
biomedich-872	135	48	.	.	PROPN
biomedich-872	135	49	,	,	PUNCT
biomedich-872	135	50	2021	2021	NUM
biomedich-872	135	51	)	)	PUNCT
biomedich-872	135	52	.	.	PUNCT
biomedich-872	136	1	further	far	ADV
biomedich-872	136	2	molecular	molecular	ADJ
biomedich-872	136	3	validation	validation	NOUN
biomedich-872	136	4	was	be	AUX
biomedich-872	136	5	provided	provide	VERB
biomedich-872	136	6	by	by	ADP
biomedich-872	136	7	imaduddin	imaduddin	VERB
biomedich-872	136	8	et	et	PROPN
biomedich-872	136	9	al	al	PROPN
biomedich-872	136	10	.	.	PUNCT
biomedich-872	137	1	(	(	PUNCT
biomedich-872	137	2	2024	2024	NUM
biomedich-872	137	3	)	)	PUNCT
biomedich-872	137	4	,	,	PUNCT
biomedich-872	137	5	who	who	PRON
biomedich-872	137	6	demonstrated	demonstrate	VERB
biomedich-872	137	7	that	that	SCONJ
biomedich-872	137	8	p.	p.	NOUN
biomedich-872	137	9	angulata	angulata	ADJ
biomedich-872	137	10	extract	extract	NOUN
biomedich-872	137	11	significantly	significantly	ADV
biomedich-872	137	12	downregulated	downregulate	VERB
biomedich-872	137	13	fibrosisrelated	fibrosisrelate	VERB
biomedich-872	137	14	genes	gene	NOUN
biomedich-872	137	15	such	such	ADJ
biomedich-872	137	16	as	as	ADP
biomedich-872	137	17	nox4	nox4	PROPN
biomedich-872	137	18	,	,	PUNCT
biomedich-872	137	19	mmp8	mmp8	PROPN
biomedich-872	137	20	,	,	PUNCT
biomedich-872	137	21	and	and	CCONJ
biomedich-872	137	22	klf4	klf4	NOUN
biomedich-872	137	23	in	in	ADP
biomedich-872	137	24	a	a	DET
biomedich-872	137	25	bleomycin	bleomycin	NOUN
biomedich-872	137	26	-	-	PUNCT
biomedich-872	137	27	induced	induce	VERB
biomedich-872	137	28	mouse	mouse	NOUN
biomedich-872	137	29	model	model	NOUN
biomedich-872	137	30	.	.	PUNCT
biomedich-872	138	1	these	these	DET
biomedich-872	138	2	gene	gene	NOUN
biomedich-872	138	3	targets	target	NOUN
biomedich-872	138	4	are	be	AUX
biomedich-872	138	5	central	central	ADJ
biomedich-872	138	6	to	to	PART
biomedich-872	138	7	oxidative	oxidative	VERB
biomedich-872	138	8	stress	stress	NOUN
biomedich-872	138	9	response	response	NOUN
biomedich-872	138	10	and	and	CCONJ
biomedich-872	138	11	extracellular	extracellular	ADJ
biomedich-872	138	12	matrix	matrix	NOUN
biomedich-872	138	13	remodeling	remodeling	NOUN
biomedich-872	138	14	mechanisms	mechanism	NOUN
biomedich-872	138	15	possibly	possibly	ADV
biomedich-872	138	16	modulated	modulate	VERB
biomedich-872	138	17	via	via	ADP
biomedich-872	138	18	the	the	DET
biomedich-872	138	19	observed	observe	VERB
biomedich-872	138	20	ligand	ligand	NOUN
biomedich-872	138	21	-	-	PUNCT
biomedich-872	138	22	residue	residue	NOUN
biomedich-872	138	23	interactions	interaction	NOUN
biomedich-872	138	24	in	in	ADP
biomedich-872	138	25	silico	silico	NOUN
biomedich-872	138	26	.	.	PUNCT
biomedich-872	139	1	complementary	complementary	ADJ
biomedich-872	139	2	liver	liver	NOUN
biomedich-872	139	3	fibrosis	fibrosis	NOUN
biomedich-872	139	4	studies	study	NOUN
biomedich-872	139	5	also	also	ADV
biomedich-872	139	6	support	support	VERB
biomedich-872	139	7	p.	p.	NOUN
biomedich-872	139	8	angulata	angulata	NOUN
biomedich-872	139	9	's	's	PART
biomedich-872	139	10	systemic	systemic	ADJ
biomedich-872	139	11	antifibrotic	antifibrotic	ADJ
biomedich-872	139	12	activity	activity	NOUN
biomedich-872	139	13	.	.	PUNCT
biomedich-872	140	1	bestari	bestari	PROPN
biomedich-872	140	2	et	et	PROPN
biomedich-872	140	3	al	al	PROPN
biomedich-872	140	4	.	.	PROPN
biomedich-872	140	5	(	(	PUNCT
biomedich-872	140	6	2023	2023	NUM
biomedich-872	140	7	)	)	PUNCT
biomedich-872	140	8	and	and	CCONJ
biomedich-872	140	9	rohmawaty	rohmawaty	VERB
biomedich-872	140	10	et	et	PROPN
biomedich-872	140	11	al	al	PROPN
biomedich-872	140	12	.	.	PROPN
biomedich-872	141	1	(	(	PUNCT
biomedich-872	141	2	2023	2023	NUM
biomedich-872	141	3	)	)	PUNCT
biomedich-872	141	4	observed	observe	VERB
biomedich-872	141	5	improvements	improvement	NOUN
biomedich-872	141	6	in	in	ADP
biomedich-872	141	7	liver	liver	NOUN
biomedich-872	141	8	histopathology	histopathology	NOUN
biomedich-872	141	9	,	,	PUNCT
biomedich-872	141	10	alt	alt	ADJ
biomedich-872	141	11	,	,	PUNCT
biomedich-872	141	12	and	and	CCONJ
biomedich-872	141	13	cholesterol	cholesterol	NOUN
biomedich-872	141	14	levels	level	NOUN
biomedich-872	141	15	in	in	ADP
biomedich-872	141	16	nafld	nafld	ADJ
biomedich-872	141	17	models	model	NOUN
biomedich-872	141	18	,	,	PUNCT
biomedich-872	141	19	while	while	SCONJ
biomedich-872	141	20	rohmawaty	rohmawaty	NOUN
biomedich-872	141	21	et	et	PROPN
biomedich-872	141	22	al	al	PROPN
biomedich-872	141	23	.	.	PROPN
biomedich-872	142	1	(	(	PUNCT
biomedich-872	142	2	2021	2021	NUM
biomedich-872	142	3	)	)	PUNCT
biomedich-872	142	4	reported	report	VERB
biomedich-872	142	5	reduced	reduced	ADJ
biomedich-872	142	6	fibrosis	fibrosis	NOUN
biomedich-872	142	7	scores	score	NOUN
biomedich-872	142	8	and	and	CCONJ
biomedich-872	142	9	serum	serum	NOUN
biomedich-872	142	10	transaminase	transaminase	NOUN
biomedich-872	142	11	levels	level	NOUN
biomedich-872	142	12	in	in	ADP
biomedich-872	142	13	ccl₄-induced	ccl₄-induced	ADJ
biomedich-872	142	14	liver	liver	NOUN
biomedich-872	142	15	fibrosis	fibrosis	NOUN
biomedich-872	142	16	rats	rat	NOUN
biomedich-872	142	17	treated	treat	VERB
biomedich-872	142	18	with	with	ADP
biomedich-872	142	19	the	the	DET
biomedich-872	142	20	plant	plant	NOUN
biomedich-872	142	21	extract	extract	NOUN
biomedich-872	142	22	.	.	PUNCT
biomedich-872	143	1	taken	take	VERB
biomedich-872	143	2	together	together	ADV
biomedich-872	143	3	,	,	PUNCT
biomedich-872	143	4	these	these	DET
biomedich-872	143	5	findings	finding	NOUN
biomedich-872	143	6	demonstrate	demonstrate	VERB
biomedich-872	143	7	that	that	SCONJ
biomedich-872	143	8	the	the	DET
biomedich-872	143	9	consistent	consistent	ADJ
biomedich-872	143	10	interaction	interaction	NOUN
biomedich-872	143	11	of	of	ADP
biomedich-872	143	12	docked	docked	ADJ
biomedich-872	143	13	flavonoids	flavonoid	NOUN
biomedich-872	143	14	with	with	ADP
biomedich-872	143	15	polar	polar	ADJ
biomedich-872	143	16	and	and	CCONJ
biomedich-872	143	17	hydrophobic	hydrophobic	NOUN
biomedich-872	143	18	residues	residue	NOUN
biomedich-872	143	19	particularly	particularly	ADV
biomedich-872	143	20	asp184	asp184	PROPN
biomedich-872	143	21	,	,	PUNCT
biomedich-872	143	22	glu121	glu121	NOUN
biomedich-872	143	23	,	,	PUNCT
biomedich-872	143	24	and	and	CCONJ
biomedich-872	143	25	val57	val57	PROPN
biomedich-872	143	26	may	may	AUX
biomedich-872	143	27	underlie	underlie	VERB
biomedich-872	143	28	the	the	DET
biomedich-872	143	29	extract	extract	NOUN
biomedich-872	143	30	's	's	PART
biomedich-872	143	31	observed	observe	VERB
biomedich-872	143	32	antifibrotic	antifibrotic	ADJ
biomedich-872	143	33	efficacy	efficacy	NOUN
biomedich-872	143	34	,	,	PUNCT
biomedich-872	143	35	thus	thus	ADV
biomedich-872	143	36	reinforcing	reinforce	VERB
biomedich-872	143	37	p.	p.	NOUN
biomedich-872	143	38	angulata	angulata	NOUN
biomedich-872	143	39	’s	’s	PART
biomedich-872	143	40	therapeutic	therapeutic	ADJ
biomedich-872	143	41	promise	promise	NOUN
biomedich-872	143	42	across	across	ADP
biomedich-872	143	43	multiple	multiple	ADJ
biomedich-872	143	44	fibrotic	fibrotic	ADJ
biomedich-872	143	45	disease	disease	NOUN
biomedich-872	143	46	models	model	NOUN
biomedich-872	143	47	.	.	PUNCT
biomedich-872	144	1	the	the	DET
biomedich-872	144	2	admet	admet	PROPN
biomedich-872	144	3	profiles	profile	NOUN
biomedich-872	144	4	indicate	indicate	VERB
biomedich-872	144	5	that	that	SCONJ
biomedich-872	144	6	several	several	ADJ
biomedich-872	144	7	physalis	physali	NOUN
biomedich-872	144	8	angulata	angulata	ADJ
biomedich-872	144	9	compounds	compound	NOUN
biomedich-872	144	10	,	,	PUNCT
biomedich-872	144	11	particularly	particularly	ADV
biomedich-872	144	12	tangeretin	tangeretin	ADJ
biomedich-872	144	13	and	and	CCONJ
biomedich-872	144	14	apigenin	apigenin	ADJ
biomedich-872	144	15	,	,	PUNCT
biomedich-872	144	16	possess	possess	VERB
biomedich-872	144	17	favorable	favorable	ADJ
biomedich-872	144	18	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	144	19	characteristics	characteristic	NOUN
biomedich-872	144	20	,	,	PUNCT
biomedich-872	144	21	including	include	VERB
biomedich-872	144	22	high	high	ADJ
biomedich-872	144	23	intestinal	intestinal	ADJ
biomedich-872	144	24	absorption	absorption	NOUN
biomedich-872	144	25	and	and	CCONJ
biomedich-872	144	26	relatively	relatively	ADV
biomedich-872	144	27	fast	fast	ADJ
biomedich-872	144	28	systemic	systemic	ADJ
biomedich-872	144	29	clearance	clearance	NOUN
biomedich-872	144	30	(	(	PUNCT
biomedich-872	144	31	farid	farid	PROPN
biomedich-872	144	32	et	et	PROPN
biomedich-872	144	33	al	al	PROPN
biomedich-872	144	34	.	.	PROPN
biomedich-872	144	35	,	,	PUNCT
biomedich-872	144	36	2025	2025	NUM
biomedich-872	144	37	)	)	PUNCT
biomedich-872	144	38	.	.	PUNCT
biomedich-872	145	1	however	however	ADV
biomedich-872	145	2	,	,	PUNCT
biomedich-872	145	3	poor	poor	ADJ
biomedich-872	145	4	bbb	bbb	NOUN
biomedich-872	145	5	and	and	CCONJ
biomedich-872	145	6	cns	cns	NOUN
biomedich-872	145	7	permeability	permeability	NOUN
biomedich-872	145	8	across	across	ADP
biomedich-872	145	9	all	all	DET
biomedich-872	145	10	compounds	compound	NOUN
biomedich-872	145	11	may	may	AUX
biomedich-872	145	12	limit	limit	VERB
biomedich-872	145	13	their	their	PRON
biomedich-872	145	14	central	central	ADJ
biomedich-872	145	15	nervous	nervous	ADJ
biomedich-872	145	16	system	system	NOUN
biomedich-872	145	17	effects	effect	NOUN
biomedich-872	145	18	,	,	PUNCT
biomedich-872	145	19	suggesting	suggest	VERB
biomedich-872	145	20	a	a	DET
biomedich-872	145	21	more	more	ADV
biomedich-872	145	22	localized	localized	ADJ
biomedich-872	145	23	or	or	CCONJ
biomedich-872	145	24	peripheral	peripheral	ADJ
biomedich-872	145	25	antifibrotic	antifibrotic	ADJ
biomedich-872	145	26	action	action	NOUN
biomedich-872	145	27	(	(	PUNCT
biomedich-872	145	28	utami	utami	NOUN
biomedich-872	145	29	et	et	PROPN
biomedich-872	145	30	al	al	PROPN
biomedich-872	145	31	.	.	PROPN
biomedich-872	145	32	,	,	PUNCT
biomedich-872	145	33	2025	2025	NUM
biomedich-872	145	34	)	)	PUNCT
biomedich-872	145	35	.	.	PUNCT
biomedich-872	146	1	the	the	DET
biomedich-872	146	2	absence	absence	NOUN
biomedich-872	146	3	of	of	ADP
biomedich-872	146	4	cyp2d6	cyp2d6	NOUN
biomedich-872	146	5	and	and	CCONJ
biomedich-872	146	6	oct2	oct2	NOUN
biomedich-872	146	7	interactions	interaction	NOUN
biomedich-872	146	8	reduces	reduce	VERB
biomedich-872	146	9	the	the	DET
biomedich-872	146	10	risk	risk	NOUN
biomedich-872	146	11	of	of	ADP
biomedich-872	146	12	metabolic	metabolic	NOUN
biomedich-872	146	13	and	and	CCONJ
biomedich-872	146	14	renal	renal	ADJ
biomedich-872	146	15	toxicity	toxicity	NOUN
biomedich-872	146	16	,	,	PUNCT
biomedich-872	146	17	enhancing	enhance	VERB
biomedich-872	146	18	their	their	PRON
biomedich-872	146	19	safety	safety	NOUN
biomedich-872	146	20	profile	profile	NOUN
biomedich-872	146	21	.	.	PUNCT
biomedich-872	147	1	notably	notably	ADV
biomedich-872	147	2	,	,	PUNCT
biomedich-872	147	3	the	the	DET
biomedich-872	147	4	lack	lack	NOUN
biomedich-872	147	5	of	of	ADP
biomedich-872	147	6	ames	ame	NOUN
biomedich-872	147	7	toxicity	toxicity	NOUN
biomedich-872	147	8	and	and	CCONJ
biomedich-872	147	9	hepatotoxicity	hepatotoxicity	NOUN
biomedich-872	147	10	predictions	prediction	NOUN
biomedich-872	147	11	across	across	ADP
biomedich-872	147	12	all	all	DET
biomedich-872	147	13	compounds	compound	NOUN
biomedich-872	147	14	further	far	ADV
biomedich-872	147	15	supports	support	VERB
biomedich-872	147	16	their	their	PRON
biomedich-872	147	17	potential	potential	NOUN
biomedich-872	147	18	as	as	ADP
biomedich-872	147	19	safe	safe	ADJ
biomedich-872	147	20	therapeutic	therapeutic	ADJ
biomedich-872	147	21	candidates	candidate	NOUN
biomedich-872	147	22	.	.	PUNCT
biomedich-872	148	1	overall	overall	ADV
biomedich-872	148	2	,	,	PUNCT
biomedich-872	148	3	the	the	DET
biomedich-872	148	4	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	148	5	properties	property	NOUN
biomedich-872	148	6	strengthen	strengthen	VERB
biomedich-872	148	7	the	the	DET
biomedich-872	148	8	viability	viability	NOUN
biomedich-872	148	9	of	of	ADP
biomedich-872	148	10	these	these	DET
biomedich-872	148	11	bioactive	bioactive	ADJ
biomedich-872	148	12	agents	agent	NOUN
biomedich-872	148	13	especially	especially	ADV
biomedich-872	148	14	tangeretin	tangeretin	ADJ
biomedich-872	148	15	,	,	PUNCT
biomedich-872	148	16	apigenin	apigenin	ADJ
biomedich-872	148	17	,	,	PUNCT
biomedich-872	148	18	and	and	CCONJ
biomedich-872	148	19	kaempferol	kaempferol	VERB
biomedich-872	148	20	for	for	ADP
biomedich-872	148	21	further	further	ADJ
biomedich-872	148	22	development	development	NOUN
biomedich-872	148	23	as	as	ADP
biomedich-872	148	24	anti	anti	ADJ
biomedich-872	148	25	-	-	ADJ
biomedich-872	148	26	fibrotic	fibrotic	ADJ
biomedich-872	148	27	treatments	treatment	NOUN
biomedich-872	148	28	with	with	ADP
biomedich-872	148	29	minimal	minimal	ADJ
biomedich-872	148	30	systemic	systemic	ADJ
biomedich-872	148	31	toxicity	toxicity	NOUN
biomedich-872	148	32	.	.	PUNCT
biomedich-872	149	1	this	this	DET
biomedich-872	149	2	study	study	NOUN
biomedich-872	149	3	is	be	AUX
biomedich-872	149	4	limited	limit	VERB
biomedich-872	149	5	by	by	ADP
biomedich-872	149	6	its	its	PRON
biomedich-872	149	7	reliance	reliance	NOUN
biomedich-872	149	8	on	on	ADP
biomedich-872	149	9	in	in	ADP
biomedich-872	149	10	silico	silico	NOUN
biomedich-872	149	11	predictions	prediction	NOUN
biomedich-872	149	12	,	,	PUNCT
biomedich-872	149	13	which	which	PRON
biomedich-872	149	14	,	,	PUNCT
biomedich-872	149	15	while	while	SCONJ
biomedich-872	149	16	informative	informative	ADJ
biomedich-872	149	17	,	,	PUNCT
biomedich-872	149	18	do	do	AUX
biomedich-872	149	19	not	not	PART
biomedich-872	149	20	fully	fully	ADV
biomedich-872	149	21	replicate	replicate	VERB
biomedich-872	149	22	the	the	DET
biomedich-872	149	23	complexity	complexity	NOUN
biomedich-872	149	24	of	of	ADP
biomedich-872	149	25	biological	biological	ADJ
biomedich-872	149	26	systems	system	NOUN
biomedich-872	149	27	.	.	PUNCT
biomedich-872	150	1	the	the	DET
biomedich-872	150	2	docking	docking	NOUN
biomedich-872	150	3	results	result	NOUN
biomedich-872	150	4	and	and	CCONJ
biomedich-872	150	5	admet	admet	PROPN
biomedich-872	150	6	simulations	simulation	NOUN
biomedich-872	150	7	require	require	VERB
biomedich-872	150	8	further	further	ADJ
biomedich-872	150	9	validation	validation	NOUN
biomedich-872	150	10	through	through	ADP
biomedich-872	150	11	experimental	experimental	ADJ
biomedich-872	150	12	assays	assay	NOUN
biomedich-872	150	13	,	,	PUNCT
biomedich-872	150	14	such	such	ADJ
biomedich-872	150	15	as	as	ADP
biomedich-872	150	16	in	in	ADP
biomedich-872	150	17	vitro	vitro	X
biomedich-872	150	18	tests	test	NOUN
biomedich-872	150	19	on	on	ADP
biomedich-872	150	20	lung	lung	NOUN
biomedich-872	150	21	fibroblasts	fibroblast	NOUN
biomedich-872	150	22	or	or	CCONJ
biomedich-872	150	23	in	in	ADP
biomedich-872	150	24	vivo	vivo	NOUN
biomedich-872	150	25	models	model	NOUN
biomedich-872	150	26	of	of	ADP
biomedich-872	150	27	pulmonary	pulmonary	ADJ
biomedich-872	150	28	fibrosis	fibrosis	NOUN
biomedich-872	150	29	.	.	PUNCT
biomedich-872	151	1	additionally	additionally	ADV
biomedich-872	151	2	,	,	PUNCT
biomedich-872	151	3	the	the	DET
biomedich-872	151	4	pharmacokinetic	pharmacokinetic	ADJ
biomedich-872	151	5	predictions	prediction	NOUN
biomedich-872	151	6	need	need	VERB
biomedich-872	151	7	to	to	PART
biomedich-872	151	8	be	be	AUX
biomedich-872	151	9	confirmed	confirm	VERB
biomedich-872	151	10	by	by	ADP
biomedich-872	151	11	actual	actual	ADJ
biomedich-872	151	12	bioavailability	bioavailability	NOUN
biomedich-872	151	13	and	and	CCONJ
biomedich-872	151	14	toxicity	toxicity	NOUN
biomedich-872	151	15	studies	study	NOUN
biomedich-872	151	16	.	.	PUNCT
biomedich-872	152	1	future	future	ADJ
biomedich-872	152	2	research	research	NOUN
biomedich-872	152	3	should	should	AUX
biomedich-872	152	4	focus	focus	VERB
biomedich-872	152	5	on	on	ADP
biomedich-872	152	6	elucidating	elucidate	VERB
biomedich-872	152	7	the	the	DET
biomedich-872	152	8	specific	specific	ADJ
biomedich-872	152	9	molecular	molecular	ADJ
biomedich-872	152	10	mechanisms	mechanism	NOUN
biomedich-872	152	11	of	of	ADP
biomedich-872	152	12	promising	promising	ADJ
biomedich-872	152	13	compounds	compound	NOUN
biomedich-872	152	14	like	like	ADP
biomedich-872	152	15	myricetrin	myricetrin	NOUN
biomedich-872	152	16	and	and	CCONJ
biomedich-872	152	17	apigenin	apigenin	ADJ
biomedich-872	152	18	,	,	PUNCT
biomedich-872	152	19	particularly	particularly	ADV
biomedich-872	152	20	their	their	PRON
biomedich-872	152	21	influence	influence	NOUN
biomedich-872	152	22	on	on	ADP
biomedich-872	152	23	the	the	DET
biomedich-872	152	24	pathway	pathway	NOUN
biomedich-872	152	25	and	and	CCONJ
biomedich-872	152	26	fibrotic	fibrotic	ADJ
biomedich-872	152	27	markers	marker	NOUN
biomedich-872	152	28	.	.	PUNCT
biomedich-872	153	1	such	such	ADJ
biomedich-872	153	2	investigations	investigation	NOUN
biomedich-872	153	3	will	will	AUX
biomedich-872	153	4	be	be	AUX
biomedich-872	153	5	essential	essential	ADJ
biomedich-872	153	6	to	to	PART
biomedich-872	153	7	assess	assess	VERB
biomedich-872	153	8	their	their	PRON
biomedich-872	153	9	therapeutic	therapeutic	ADJ
biomedich-872	153	10	relevance	relevance	NOUN
biomedich-872	153	11	and	and	CCONJ
biomedich-872	153	12	advance	advance	VERB
biomedich-872	153	13	them	they	PRON
biomedich-872	153	14	as	as	ADP
biomedich-872	153	15	potential	potential	ADJ
biomedich-872	153	16	candidates	candidate	NOUN
biomedich-872	153	17	for	for	ADP
biomedich-872	153	18	natural	natural	ADJ
biomedich-872	153	19	anti	anti	ADJ
biomedich-872	153	20	-	-	ADJ
biomedich-872	153	21	fibrotic	fibrotic	ADJ
biomedich-872	153	22	drug	drug	NOUN
biomedich-872	153	23	development	development	NOUN
biomedich-872	153	24	.	.	PUNCT
biomedich-872	154	1	conclusions	conclusion	NOUN
biomedich-872	154	2	several	several	ADJ
biomedich-872	154	3	bioactive	bioactive	ADJ
biomedich-872	154	4	compounds	compound	NOUN
biomedich-872	154	5	from	from	ADP
biomedich-872	154	6	physalis	physali	NOUN
biomedich-872	154	7	angulata	angulata	ADJ
biomedich-872	154	8	,	,	PUNCT
biomedich-872	154	9	particularly	particularly	ADV
biomedich-872	154	10	myricetrin	myricetrin	NOUN
biomedich-872	154	11	(	(	PUNCT
biomedich-872	154	12	δg	δg	NOUN
biomedich-872	154	13	=	=	PUNCT
biomedich-872	154	14	-9.6	-9.6	NOUN
biomedich-872	154	15	kcal	kcal	PROPN
biomedich-872	154	16	/	/	SYM
biomedich-872	154	17	mol	mol	NOUN
biomedich-872	154	18	)	)	PUNCT
biomedich-872	154	19	,	,	PUNCT
biomedich-872	154	20	apigenin	apigenin	PROPN
biomedich-872	154	21	(	(	PUNCT
biomedich-872	154	22	8.5	8.5	NUM
biomedich-872	154	23	kcal	kcal	NOUN
biomedich-872	154	24	/	/	SYM
biomedich-872	154	25	mol	mol	NOUN
biomedich-872	154	26	)	)	PUNCT
biomedich-872	154	27	,	,	PUNCT
biomedich-872	154	28	and	and	CCONJ
biomedich-872	154	29	eriodictyol	eriodictyol	NOUN
biomedich-872	154	30	(	(	PUNCT
biomedich-872	154	31	-8.9	-8.9	INTJ
biomedich-872	154	32	kcal	kcal	PROPN
biomedich-872	154	33	/	/	SYM
biomedich-872	154	34	mol	mol	NOUN
biomedich-872	154	35	)	)	PUNCT
biomedich-872	154	36	,	,	PUNCT
biomedich-872	154	37	demonstrated	demonstrate	VERB
biomedich-872	154	38	strong	strong	ADJ
biomedich-872	154	39	binding	bind	VERB
biomedich-872	154	40	affinities	affinity	NOUN
biomedich-872	154	41	to	to	ADP
biomedich-872	154	42	the	the	DET
biomedich-872	154	43	pi3k	pi3k	PROPN
biomedich-872	154	44	/	/	SYM
biomedich-872	154	45	akt	akt	PROPN
biomedich-872	154	46	protein	protein	NOUN
biomedich-872	154	47	and	and	CCONJ
biomedich-872	154	48	interacted	interact	VERB
biomedich-872	154	49	with	with	ADP
biomedich-872	154	50	key	key	ADJ
biomedich-872	154	51	residues	residue	NOUN
biomedich-872	154	52	like	like	ADP
biomedich-872	154	53	asp184	asp184	NOUN
biomedich-872	154	54	and	and	CCONJ
biomedich-872	154	55	glu121	glu121	NOUN
biomedich-872	154	56	,	,	PUNCT
biomedich-872	154	57	suggesting	suggest	VERB
biomedich-872	154	58	potential	potential	ADJ
biomedich-872	154	59	antifibrotic	antifibrotic	ADJ
biomedich-872	154	60	activity	activity	NOUN
biomedich-872	154	61	.	.	PUNCT
biomedich-872	155	1	admet	admet	PROPN
biomedich-872	155	2	predictions	prediction	NOUN
biomedich-872	155	3	indicated	indicate	VERB
biomedich-872	155	4	favorable	favorable	ADJ
biomedich-872	155	5	absorption	absorption	NOUN
biomedich-872	155	6	and	and	CCONJ
biomedich-872	155	7	safety	safety	NOUN
biomedich-872	155	8	profiles	profile	NOUN
biomedich-872	155	9	,	,	PUNCT
biomedich-872	155	10	especially	especially	ADV
biomedich-872	155	11	for	for	ADP
biomedich-872	155	12	tangeretin	tangeretin	ADJ
biomedich-872	155	13	and	and	CCONJ
biomedich-872	155	14	apigenin	apigenin	ADJ
biomedich-872	155	15	.	.	PUNCT
biomedich-872	156	1	these	these	DET
biomedich-872	156	2	findings	finding	NOUN
biomedich-872	156	3	highlight	highlight	VERB
biomedich-872	156	4	the	the	DET
biomedich-872	156	5	therapeutic	therapeutic	ADJ
biomedich-872	156	6	promise	promise	NOUN
biomedich-872	156	7	of	of	ADP
biomedich-872	156	8	p.	p.	NOUN
biomedich-872	156	9	angulata	angulata	ADJ
biomedich-872	156	10	flavonoids	flavonoid	NOUN
biomedich-872	156	11	in	in	ADP
biomedich-872	156	12	targeting	target	VERB
biomedich-872	156	13	fibrotic	fibrotic	ADJ
biomedich-872	156	14	pathways	pathway	NOUN
biomedich-872	156	15	.	.	PUNCT
biomedich-872	157	1	farid	farid	PROPN
biomedich-872	157	2	et	et	PROPN
biomedich-872	157	3	al	al	PROPN
biomedich-872	157	4	.	.	PROPN
biomedich-872	157	5	–	–	PUNCT
biomedich-872	157	6	predicting	predict	VERB
biomedich-872	157	7	the	the	DET
biomedich-872	157	8	anti	anti	ADJ
biomedich-872	157	9	-	-	ADJ
biomedich-872	157	10	pulmonary	pulmonary	ADJ
biomedich-872	157	11	fibrosis	fibrosis	NOUN
biomedich-872	157	12	potential	potential	NOUN
biomedich-872	157	13	…	…	PUNCT
biomedich-872	157	14	823	823	NUM
biomedich-872	157	15	further	far	ADV
biomedich-872	157	16	in	in	ADP
biomedich-872	157	17	vitro	vitro	X
biomedich-872	157	18	and	and	CCONJ
biomedich-872	157	19	in	in	ADP
biomedich-872	157	20	vivo	vivo	ADJ
biomedich-872	157	21	studies	study	NOUN
biomedich-872	157	22	are	be	AUX
biomedich-872	157	23	needed	need	VERB
biomedich-872	157	24	to	to	PART
biomedich-872	157	25	validate	validate	VERB
biomedich-872	157	26	their	their	PRON
biomedich-872	157	27	mechanisms	mechanism	NOUN
biomedich-872	157	28	and	and	CCONJ
biomedich-872	157	29	efficacy	efficacy	NOUN
biomedich-872	157	30	as	as	ADP
biomedich-872	157	31	multi	multi	ADJ
biomedich-872	157	32	target	target	NOUN
biomedich-872	157	33	agents	agent	NOUN
biomedich-872	157	34	for	for	ADP
biomedich-872	157	35	pulmonary	pulmonary	ADJ
biomedich-872	157	36	fibrosis	fibrosis	NOUN
biomedich-872	157	37	treatment	treatment	NOUN
biomedich-872	157	38	.	.	PUNCT
biomedich-872	158	1	acknowledgements	acknowledgement	NOUN
biomedich-872	158	2	:	:	PUNCT
biomedich-872	158	3	this	this	DET
biomedich-872	158	4	study	study	NOUN
biomedich-872	158	5	,	,	PUNCT
biomedich-872	158	6	and	and	CCONJ
biomedich-872	158	7	that	that	SCONJ
biomedich-872	158	8	the	the	DET
biomedich-872	158	9	research	research	NOUN
biomedich-872	158	10	was	be	AUX
biomedich-872	158	11	conducted	conduct	VERB
biomedich-872	158	12	without	without	ADP
biomedich-872	158	13	any	any	DET
biomedich-872	158	14	external	external	ADJ
biomedich-872	158	15	funding	funding	NOUN
biomedich-872	158	16	.	.	PUNCT
biomedich-872	159	1	all	all	DET
biomedich-872	159	2	necessary	necessary	ADJ
biomedich-872	159	3	details	detail	NOUN
biomedich-872	159	4	have	have	AUX
biomedich-872	159	5	been	be	AUX
biomedich-872	159	6	fully	fully	ADV
biomedich-872	159	7	disclosed	disclose	VERB
biomedich-872	159	8	within	within	ADP
biomedich-872	159	9	this	this	DET
biomedich-872	159	10	article	article	NOUN
biomedich-872	159	11	.	.	PUNCT
biomedich-872	160	1	authors	author	NOUN
biomedich-872	160	2	’	'	PUNCT
biomedich-872	160	3	contributions	contribution	NOUN
biomedich-872	160	4	:	:	PUNCT
biomedich-872	160	5	mf	mf	NOUN
biomedich-872	160	6	and	and	CCONJ
biomedich-872	160	7	aak	aak	NOUN
biomedich-872	160	8	designed	design	VERB
biomedich-872	160	9	the	the	DET
biomedich-872	160	10	insilico	insilico	NOUN
biomedich-872	160	11	study	study	NOUN
biomedich-872	160	12	.	.	PUNCT
biomedich-872	161	1	ndo	ndo	PROPN
biomedich-872	161	2	and	and	CCONJ
biomedich-872	161	3	sr	sr	PROPN
biomedich-872	161	4	conducted	conduct	VERB
biomedich-872	161	5	the	the	DET
biomedich-872	161	6	computational	computational	ADJ
biomedich-872	161	7	analyses	analysis	NOUN
biomedich-872	161	8	.	.	PUNCT
biomedich-872	162	1	da	da	PROPN
biomedich-872	162	2	processed	process	VERB
biomedich-872	162	3	and	and	CCONJ
biomedich-872	162	4	analyzed	analyze	VERB
biomedich-872	162	5	the	the	DET
biomedich-872	162	6	data	datum	NOUN
biomedich-872	162	7	.	.	PUNCT
biomedich-872	163	1	mf	mf	NOUN
biomedich-872	163	2	and	and	CCONJ
biomedich-872	163	3	war	war	NOUN
biomedich-872	163	4	drafted	draft	VERB
biomedich-872	163	5	the	the	DET
biomedich-872	163	6	manuscript	manuscript	NOUN
biomedich-872	163	7	.	.	PUNCT
biomedich-872	164	1	all	all	DET
biomedich-872	164	2	authors	author	NOUN
biomedich-872	164	3	reviewed	review	VERB
biomedich-872	164	4	and	and	CCONJ
biomedich-872	164	5	approved	approve	VERB
biomedich-872	164	6	the	the	DET
biomedich-872	164	7	final	final	ADJ
biomedich-872	164	8	version	version	NOUN
biomedich-872	164	9	of	of	ADP
biomedich-872	164	10	the	the	DET
biomedich-872	164	11	manuscript	manuscript	NOUN
biomedich-872	164	12	.	.	PUNCT
biomedich-872	165	1	competing	compete	VERB
biomedich-872	165	2	interests	interest	NOUN
biomedich-872	165	3	:	:	PUNCT
biomedich-872	165	4	the	the	DET
biomedich-872	165	5	authors	author	NOUN
biomedich-872	165	6	declare	declare	VERB
biomedich-872	165	7	that	that	SCONJ
biomedich-872	165	8	there	there	PRON
biomedich-872	165	9	are	be	VERB
biomedich-872	165	10	no	no	DET
biomedich-872	165	11	competing	compete	VERB
biomedich-872	165	12	interests	interest	NOUN
biomedich-872	165	13	.	.	PUNCT
biomedich-872	166	1	references	reference	NOUN
biomedich-872	166	2	alfaro	alfaro	NOUN
biomedich-872	166	3	,	,	PUNCT
biomedich-872	166	4	t.	t.	NOUN
biomedich-872	166	5	m.	m.	NOUN
biomedich-872	166	6	,	,	PUNCT
biomedich-872	166	7	&	&	CCONJ
biomedich-872	166	8	robalo	robalo	PROPN
biomedich-872	166	9	cordeiro	cordeiro	PROPN
biomedich-872	166	10	,	,	PUNCT
biomedich-872	166	11	c.	c.	PROPN
biomedich-872	166	12	(	(	PUNCT
biomedich-872	166	13	2020	2020	NUM
biomedich-872	166	14	)	)	PUNCT
biomedich-872	166	15	.	.	PUNCT
biomedich-872	167	1	comorbidity	comorbidity	NOUN
biomedich-872	167	2	in	in	ADP
biomedich-872	167	3	idiopathic	idiopathic	ADJ
biomedich-872	167	4	pulmonary	pulmonary	ADJ
biomedich-872	167	5	fibrosis	fibrosis	NOUN
biomedich-872	167	6	what	what	PRON
biomedich-872	167	7	can	can	AUX
biomedich-872	167	8	biomarkers	biomarker	NOUN
biomedich-872	167	9	tell	tell	VERB
biomedich-872	167	10	us	we	PRON
biomedich-872	167	11	?	?	PUNCT
biomedich-872	168	1	therapeutic	therapeutic	ADJ
biomedich-872	168	2	advances	advance	NOUN
biomedich-872	168	3	in	in	ADP
biomedich-872	168	4	respiratory	respiratory	ADJ
biomedich-872	168	5	disease	disease	NOUN
biomedich-872	168	6	,	,	PUNCT
biomedich-872	168	7	14	14	NUM
biomedich-872	168	8	.	.	PUNCT
biomedich-872	169	1	https://doi.org/10.1177/1753466620910092	https://doi.org/10.1177/1753466620910092	NOUN
biomedich-872	169	2	ananthathandavan	ananthathandavan	VERB
biomedich-872	169	3	,	,	PUNCT
biomedich-872	169	4	p.	p.	PROPN
biomedich-872	169	5	,	,	PUNCT
biomedich-872	169	6	&	&	CCONJ
biomedich-872	169	7	narayanasamy	narayanasamy	NOUN
biomedich-872	169	8	,	,	PUNCT
biomedich-872	169	9	d.	d.	PROPN
biomedich-872	169	10	(	(	PUNCT
biomedich-872	169	11	2024	2024	NUM
biomedich-872	169	12	)	)	PUNCT
biomedich-872	169	13	.	.	PUNCT
biomedich-872	170	1	computational	computational	ADJ
biomedich-872	170	2	drug	drug	NOUN
biomedich-872	170	3	–	–	PUNCT
biomedich-872	170	4	drug	drug	NOUN
biomedich-872	170	5	interaction	interaction	NOUN
biomedich-872	170	6	prediction	prediction	NOUN
biomedich-872	170	7	mediated	mediate	VERB
biomedich-872	170	8	by	by	ADP
biomedich-872	170	9	cyp450	cyp450	NOUN
biomedich-872	170	10	isoforms	isoform	NOUN
biomedich-872	170	11	of	of	ADP
biomedich-872	170	12	ilaprazole	ilaprazole	NOUN
biomedich-872	170	13	coadministered	coadministere	VERB
biomedich-872	170	14	with	with	ADP
biomedich-872	170	15	clopidogrel	clopidogrel	NOUN
biomedich-872	170	16	.	.	PUNCT
biomedich-872	171	1	future	future	ADJ
biomedich-872	171	2	science	science	NOUN
biomedich-872	171	3	oa	oa	NOUN
biomedich-872	171	4	,	,	PUNCT
biomedich-872	171	5	10(1	10(1	NUM
biomedich-872	171	6	)	)	PUNCT
biomedich-872	171	7	.	.	PUNCT
biomedich-872	172	1	https://doi.org/10.2144/fsoa-2023-0277	https://doi.org/10.2144/fsoa-2023-0277	PROPN
biomedich-872	172	2	bestari	bestari	PROPN
biomedich-872	172	3	,	,	PUNCT
biomedich-872	172	4	m.	m.	PROPN
biomedich-872	172	5	b.	b.	PROPN
biomedich-872	172	6	,	,	PUNCT
biomedich-872	172	7	rohmawaty	rohmawaty	PROPN
biomedich-872	172	8	,	,	PUNCT
biomedich-872	172	9	e.	e.	PROPN
biomedich-872	172	10	,	,	PUNCT
biomedich-872	172	11	rosdianto	rosdianto	NOUN
biomedich-872	172	12	,	,	PUNCT
biomedich-872	172	13	a.	a.	NOUN
biomedich-872	172	14	m.	m.	NOUN
biomedich-872	172	15	,	,	PUNCT
biomedich-872	172	16	usman	usman	PROPN
biomedich-872	172	17	,	,	PUNCT
biomedich-872	172	18	h.	h.	PROPN
biomedich-872	172	19	a.	a.	PROPN
biomedich-872	172	20	,	,	PUNCT
biomedich-872	172	21	saragih	saragih	PROPN
biomedich-872	172	22	,	,	PUNCT
biomedich-872	172	23	w.	w.	PROPN
biomedich-872	172	24	a.	a.	PROPN
biomedich-872	172	25	,	,	PUNCT
biomedich-872	172	26	zuhrotun	zuhrotun	PROPN
biomedich-872	172	27	,	,	PUNCT
biomedich-872	172	28	a.	a.	NOUN
biomedich-872	172	29	,	,	PUNCT
biomedich-872	172	30	hendriani	hendriani	PROPN
biomedich-872	172	31	,	,	PUNCT
biomedich-872	172	32	r.	r.	PROPN
biomedich-872	172	33	,	,	PUNCT
biomedich-872	172	34	wardhana	wardhana	PROPN
biomedich-872	172	35	,	,	PUNCT
biomedich-872	172	36	y.	y.	PROPN
biomedich-872	172	37	w.	w.	PROPN
biomedich-872	172	38	,	,	PUNCT
biomedich-872	172	39	ekawardhani	ekawardhani	PROPN
biomedich-872	172	40	,	,	PUNCT
biomedich-872	172	41	s.	s.	PROPN
biomedich-872	172	42	,	,	PUNCT
biomedich-872	172	43	lina	lina	PROPN
biomedich-872	172	44	wiraswati	wiraswati	PROPN
biomedich-872	172	45	,	,	PUNCT
biomedich-872	172	46	h.	h.	PROPN
biomedich-872	172	47	,	,	PUNCT
biomedich-872	172	48	agustanti	agustanti	PROPN
biomedich-872	172	49	,	,	PUNCT
biomedich-872	172	50	n.	n.	NOUN
biomedich-872	172	51	,	,	PUNCT
biomedich-872	172	52	dewi	dewi	PROPN
biomedich-872	172	53	,	,	PUNCT
biomedich-872	172	54	s.	s.	PROPN
biomedich-872	172	55	,	,	PUNCT
biomedich-872	172	56	&	&	CCONJ
biomedich-872	172	57	wijaya	wijaya	PROPN
biomedich-872	172	58	,	,	PUNCT
biomedich-872	172	59	m.	m.	NOUN
biomedich-872	172	60	p.	p.	PROPN
biomedich-872	172	61	(	(	PUNCT
biomedich-872	172	62	2023	2023	NUM
biomedich-872	172	63	)	)	PUNCT
biomedich-872	172	64	.	.	PUNCT
biomedich-872	173	1	physalis	physalis	PROPN
biomedich-872	173	2	angulata	angulata	PROPN
biomedich-872	173	3	linn	linn	PROPN
biomedich-872	173	4	.	.	PUNCT
biomedich-872	174	1	as	as	ADP
biomedich-872	174	2	a	a	DET
biomedich-872	174	3	potential	potential	ADJ
biomedich-872	174	4	liver	liver	NOUN
biomedich-872	174	5	antifibrotic	antifibrotic	ADJ
biomedich-872	174	6	agent	agent	NOUN
biomedich-872	174	7	in	in	ADP
biomedich-872	174	8	rats	rat	NOUN
biomedich-872	174	9	.	.	PUNCT
biomedich-872	175	1	the	the	DET
biomedich-872	175	2	indonesian	indonesian	ADJ
biomedich-872	175	3	journal	journal	PROPN
biomedich-872	175	4	of	of	ADP
biomedich-872	175	5	gastroenterology	gastroenterology	NOUN
biomedich-872	175	6	,	,	PUNCT
biomedich-872	175	7	24(3	24(3	NUM
biomedich-872	175	8	)	)	PUNCT
biomedich-872	175	9	.	.	PUNCT
biomedich-872	176	1	ekeke	ekeke	ADJ
biomedich-872	176	2	,	,	PUNCT
biomedich-872	176	3	c.	c.	NOUN
biomedich-872	176	4	,	,	PUNCT
biomedich-872	176	5	obute	obute	PROPN
biomedich-872	176	6	,	,	PUNCT
biomedich-872	176	7	g.	g.	PROPN
biomedich-872	176	8	c.	c.	PROPN
biomedich-872	176	9	,	,	PUNCT
biomedich-872	176	10	&	&	CCONJ
biomedich-872	176	11	ogazie	ogazie	PROPN
biomedich-872	176	12	,	,	PUNCT
biomedich-872	176	13	c.	c.	PROPN
biomedich-872	176	14	a.	a.	PROPN
biomedich-872	176	15	(	(	PUNCT
biomedich-872	176	16	2019	2019	NUM
biomedich-872	176	17	)	)	PUNCT
biomedich-872	176	18	.	.	PUNCT
biomedich-872	177	1	hplc	hplc	NOUN
biomedich-872	177	2	evaluation	evaluation	NOUN
biomedich-872	177	3	of	of	ADP
biomedich-872	177	4	phenolic	phenolic	ADJ
biomedich-872	177	5	compounds	compound	NOUN
biomedich-872	177	6	in	in	ADP
biomedich-872	177	7	physalis	physalis	PROPN
biomedich-872	177	8	angulata	angulata	PROPN
biomedich-872	177	9	linn	linn	PROPN
biomedich-872	177	10	.	.	PUNCT
biomedich-872	178	1	and	and	CCONJ
biomedich-872	178	2	physalis	physalis	PROPN
biomedich-872	178	3	micrantha	micrantha	PROPN
biomedich-872	178	4	linn	linn	PROPN
biomedich-872	178	5	.	.	PUNCT
biomedich-872	179	1	(	(	PUNCT
biomedich-872	179	2	solanaceae	solanaceae	PROPN
biomedich-872	179	3	)	)	PUNCT
biomedich-872	179	4	.	.	PUNCT
biomedich-872	180	1	european	european	PROPN
biomedich-872	180	2	journal	journal	PROPN
biomedich-872	180	3	of	of	ADP
biomedich-872	180	4	medicinal	medicinal	ADJ
biomedich-872	180	5	plants	plant	NOUN
biomedich-872	180	6	,	,	PUNCT
biomedich-872	180	7	1–9	1–9	NOUN
biomedich-872	180	8	.	.	PUNCT
biomedich-872	181	1	https://doi.org/10.9734/ejmp/2019/v29i230151	https://doi.org/10.9734/ejmp/2019/v29i230151	NOUN
biomedich-872	181	2	fadhli	fadhli	PROPN
biomedich-872	181	3	,	,	PUNCT
biomedich-872	181	4	h.	h.	PROPN
biomedich-872	181	5	,	,	PUNCT
biomedich-872	181	6	ruska	ruska	PROPN
biomedich-872	181	7	,	,	PUNCT
biomedich-872	181	8	s.	s.	PROPN
biomedich-872	181	9	l.	l.	PROPN
biomedich-872	181	10	,	,	PUNCT
biomedich-872	181	11	furi	furi	PROPN
biomedich-872	181	12	,	,	PUNCT
biomedich-872	181	13	m.	m.	NOUN
biomedich-872	181	14	,	,	PUNCT
biomedich-872	181	15	suhery	suhery	NOUN
biomedich-872	181	16	,	,	PUNCT
biomedich-872	181	17	w.	w.	PROPN
biomedich-872	181	18	n.	n.	PROPN
biomedich-872	181	19	,	,	PUNCT
biomedich-872	181	20	susanti	susanti	PROPN
biomedich-872	181	21	,	,	PUNCT
biomedich-872	181	22	e.	e.	PROPN
biomedich-872	181	23	,	,	PUNCT
biomedich-872	181	24	&	&	CCONJ
biomedich-872	181	25	nasution	nasution	PROPN
biomedich-872	181	26	,	,	PUNCT
biomedich-872	181	27	m.	m.	PROPN
biomedich-872	181	28	r.	r.	PROPN
biomedich-872	181	29	(	(	PUNCT
biomedich-872	181	30	2023	2023	NUM
biomedich-872	181	31	)	)	PUNCT
biomedich-872	181	32	.	.	PUNCT
biomedich-872	182	1	ciplukan	ciplukan	PROPN
biomedich-872	182	2	(	(	PUNCT
biomedich-872	182	3	physalis	physalis	VERB
biomedich-872	182	4	angulata	angulata	PROPN
biomedich-872	182	5	l.	l.	PROPN
biomedich-872	182	6	):	):	PUNCT
biomedich-872	182	7	review	review	PROPN
biomedich-872	182	8	tanaman	tanaman	NOUN
biomedich-872	182	9	liar	liar	PROPN
biomedich-872	182	10	yang	yang	PROPN
biomedich-872	182	11	berpotensi	berpotensi	PROPN
biomedich-872	182	12	sebagai	sebagai	PROPN
biomedich-872	182	13	tanaman	tanaman	PROPN
biomedich-872	182	14	obat	obat	PROPN
biomedich-872	182	15	.	.	PROPN
biomedich-872	183	1	jurnal	jurnal	PROPN
biomedich-872	183	2	farmasi	farmasi	PROPN
biomedich-872	183	3	indonesia	indonesia	PROPN
biomedich-872	183	4	,	,	PUNCT
biomedich-872	183	5	15(2	15(2	NUM
biomedich-872	183	6	)	)	PUNCT
biomedich-872	183	7	,	,	PUNCT
biomedich-872	183	8	134–141	134–141	NUM
biomedich-872	183	9	.	.	PUNCT
biomedich-872	184	1	https://doi.org/10.35617/jfionline.v15i2.144	https://doi.org/10.35617/jfionline.v15i2.144	PROPN
biomedich-872	184	2	fan	fan	PROPN
biomedich-872	184	3	,	,	PUNCT
biomedich-872	184	4	z.	z.	PROPN
biomedich-872	184	5	,	,	PUNCT
biomedich-872	184	6	pu	pu	PROPN
biomedich-872	184	7	,	,	PUNCT
biomedich-872	184	8	x.	x.	PROPN
biomedich-872	184	9	,	,	PUNCT
biomedich-872	184	10	li	li	PROPN
biomedich-872	184	11	,	,	PUNCT
biomedich-872	184	12	l.	l.	PROPN
biomedich-872	184	13	,	,	PUNCT
biomedich-872	184	14	li	li	PROPN
biomedich-872	184	15	,	,	PUNCT
biomedich-872	184	16	q.	q.	PROPN
biomedich-872	184	17	,	,	PUNCT
biomedich-872	184	18	jiang	jiang	PROPN
biomedich-872	184	19	,	,	PUNCT
biomedich-872	184	20	t.	t.	PROPN
biomedich-872	184	21	,	,	PUNCT
biomedich-872	184	22	lu	lu	PROPN
biomedich-872	184	23	,	,	PUNCT
biomedich-872	184	24	l.	l.	PROPN
biomedich-872	184	25	,	,	PUNCT
biomedich-872	184	26	tang	tang	PROPN
biomedich-872	184	27	,	,	PUNCT
biomedich-872	184	28	j.	j.	PROPN
biomedich-872	184	29	,	,	PUNCT
biomedich-872	184	30	pan	pan	PROPN
biomedich-872	184	31	,	,	PUNCT
biomedich-872	184	32	m.	m.	NOUN
biomedich-872	184	33	,	,	PUNCT
biomedich-872	184	34	zhang	zhang	PROPN
biomedich-872	184	35	,	,	PUNCT
biomedich-872	184	36	l.	l.	PROPN
biomedich-872	184	37	,	,	PUNCT
biomedich-872	184	38	&	&	CCONJ
biomedich-872	184	39	chai	chai	NOUN
biomedich-872	184	40	,	,	PUNCT
biomedich-872	184	41	y.	y.	PROPN
biomedich-872	184	42	(	(	PUNCT
biomedich-872	184	43	2023	2023	NUM
biomedich-872	184	44	)	)	PUNCT
biomedich-872	184	45	.	.	PUNCT
biomedich-872	185	1	mechanism	mechanism	NOUN
biomedich-872	185	2	of	of	ADP
biomedich-872	185	3	polygonum	polygonum	ADJ
biomedich-872	185	4	capitatum	capitatum	NOUN
biomedich-872	185	5	intervention	intervention	NOUN
biomedich-872	185	6	in	in	ADP
biomedich-872	185	7	pulmonary	pulmonary	ADJ
biomedich-872	185	8	fibrosis	fibrosis	NOUN
biomedich-872	185	9	based	base	VERB
biomedich-872	185	10	on	on	ADP
biomedich-872	185	11	network	network	NOUN
biomedich-872	185	12	pharmacology	pharmacology	NOUN
biomedich-872	185	13	and	and	CCONJ
biomedich-872	185	14	molecular	molecular	ADJ
biomedich-872	185	15	docking	docking	NOUN
biomedich-872	185	16	technology	technology	NOUN
biomedich-872	185	17	:	:	PUNCT
biomedich-872	185	18	a	a	DET
biomedich-872	185	19	review	review	NOUN
biomedich-872	185	20	.	.	PUNCT
biomedich-872	186	1	medicine	medicine	NOUN
biomedich-872	186	2	(	(	PUNCT
biomedich-872	186	3	united	united	PROPN
biomedich-872	186	4	states	states	PROPN
biomedich-872	186	5	)	)	PUNCT
biomedich-872	186	6	,	,	PUNCT
biomedich-872	186	7	102(37	102(37	NUM
biomedich-872	186	8	)	)	PUNCT
biomedich-872	186	9	,	,	PUNCT
biomedich-872	186	10	e34912	e34912	PROPN
biomedich-872	186	11	.	.	PUNCT
biomedich-872	187	1	https://doi.org/10.1097/md.0000000000034912	https://doi.org/10.1097/md.0000000000034912	PROPN
biomedich-872	187	2	farid	farid	PROPN
biomedich-872	187	3	,	,	PUNCT
biomedich-872	187	4	m.	m.	NOUN
biomedich-872	187	5	,	,	PUNCT
biomedich-872	187	6	rastrani	rastrani	NOUN
biomedich-872	187	7	,	,	PUNCT
biomedich-872	187	8	a.	a.	PROPN
biomedich-872	187	9	,	,	PUNCT
biomedich-872	187	10	rahma	rahma	PROPN
biomedich-872	187	11	,	,	PUNCT
biomedich-872	187	12	a.	a.	NOUN
biomedich-872	187	13	a.	a.	PROPN
biomedich-872	187	14	,	,	PUNCT
biomedich-872	187	15	&	&	CCONJ
biomedich-872	187	16	ramadhania	ramadhania	PROPN
biomedich-872	187	17	,	,	PUNCT
biomedich-872	187	18	w.	w.	PROPN
biomedich-872	187	19	a.	a.	PROPN
biomedich-872	187	20	(	(	PUNCT
biomedich-872	187	21	2025	2025	NUM
biomedich-872	187	22	)	)	PUNCT
biomedich-872	187	23	.	.	PUNCT
biomedich-872	188	1	prediction	prediction	NOUN
biomedich-872	188	2	of	of	ADP
biomedich-872	188	3	artocarpus	artocarpus	PROPN
biomedich-872	188	4	altilis	altili	VERB
biomedich-872	188	5	potential	potential	ADJ
biomedich-872	188	6	as	as	ADP
biomedich-872	188	7	an	an	DET
biomedich-872	188	8	anti	anti	ADJ
biomedich-872	188	9	breast	breast	NOUN
biomedich-872	188	10	cancer	cancer	NOUN
biomedich-872	188	11	by	by	ADP
biomedich-872	188	12	inhibiting	inhibit	VERB
biomedich-872	188	13	egfr	egfr	NOUN
biomedich-872	188	14	:	:	PUNCT
biomedich-872	188	15	a	a	DET
biomedich-872	188	16	molecular	molecular	ADJ
biomedich-872	188	17	docking	docking	NOUN
biomedich-872	188	18	study	study	NOUN
biomedich-872	188	19	.	.	PUNCT
biomedich-872	189	1	biology	biology	NOUN
biomedich-872	189	2	,	,	PUNCT
biomedich-872	189	3	medicine	medicine	NOUN
biomedich-872	189	4	,	,	PUNCT
biomedich-872	189	5	&	&	CCONJ
biomedich-872	189	6	natural	natural	ADJ
biomedich-872	189	7	product	product	NOUN
biomedich-872	189	8	chemistry	chemistry	NOUN
biomedich-872	189	9	,	,	PUNCT
biomedich-872	189	10	14(1	14(1	NUM
biomedich-872	189	11	)	)	PUNCT
biomedich-872	189	12	,	,	PUNCT
biomedich-872	189	13	199–204	199–204	NUM
biomedich-872	189	14	.	.	PUNCT
biomedich-872	190	1	https://doi.org/10.14421/biomedich.2025.141.199-204	https://doi.org/10.14421/biomedich.2025.141.199-204	PRON
biomedich-872	190	2	fukata	fukata	ADJ
biomedich-872	190	3	,	,	PUNCT
biomedich-872	190	4	e.	e.	PROPN
biomedich-872	190	5	,	,	PUNCT
biomedich-872	190	6	aulanni’am	aulanni’am	NOUN
biomedich-872	190	7	,	,	PUNCT
biomedich-872	190	8	rohman	rohman	NOUN
biomedich-872	190	9	,	,	PUNCT
biomedich-872	190	10	m.	m.	NOUN
biomedich-872	190	11	s.	s.	PROPN
biomedich-872	190	12	,	,	PUNCT
biomedich-872	190	13	fakurazi	fakurazi	PROPN
biomedich-872	190	14	,	,	PUNCT
biomedich-872	190	15	s.	s.	PROPN
biomedich-872	190	16	,	,	PUNCT
biomedich-872	190	17	nik	nik	PROPN
biomedich-872	190	18	malek	malek	PROPN
biomedich-872	190	19	,	,	PUNCT
biomedich-872	190	20	n.	n.	PROPN
biomedich-872	190	21	a.	a.	NOUN
biomedich-872	190	22	n.	n.	PROPN
biomedich-872	190	23	,	,	PUNCT
biomedich-872	190	24	kawamoto	kawamoto	NOUN
biomedich-872	190	25	,	,	PUNCT
biomedich-872	190	26	y.	y.	PROPN
biomedich-872	190	27	,	,	PUNCT
biomedich-872	190	28	&	&	CCONJ
biomedich-872	190	29	endharti	endharti	PROPN
biomedich-872	190	30	,	,	PUNCT
biomedich-872	190	31	a.	a.	NOUN
biomedich-872	190	32	t.	t.	PROPN
biomedich-872	190	33	(	(	PUNCT
biomedich-872	190	34	2025	2025	NUM
biomedich-872	190	35	)	)	PUNCT
biomedich-872	190	36	.	.	PUNCT
biomedich-872	191	1	in	in	ADP
biomedich-872	191	2	silico	silico	NOUN
biomedich-872	191	3	prediction	prediction	NOUN
biomedich-872	191	4	of	of	ADP
biomedich-872	191	5	cinnamaldehyde	cinnamaldehyde	NOUN
biomedich-872	191	6	on	on	ADP
biomedich-872	191	7	the	the	DET
biomedich-872	191	8	pi3k	pi3k	PROPN
biomedich-872	191	9	/	/	SYM
biomedich-872	191	10	akt	akt	PROPN
biomedich-872	191	11	pathway	pathway	NOUN
biomedich-872	191	12	activator	activator	NOUN
biomedich-872	191	13	of	of	ADP
biomedich-872	191	14	anti	anti	ADJ
biomedich-872	191	15	-	-	ADJ
biomedich-872	191	16	apoptotic	apoptotic	ADJ
biomedich-872	191	17	potential	potential	NOUN
biomedich-872	191	18	.	.	PUNCT
biomedich-872	192	1	journal	journal	NOUN
biomedich-872	192	2	of	of	ADP
biomedich-872	192	3	pharmacy	pharmacy	NOUN
biomedich-872	192	4	and	and	CCONJ
biomedich-872	192	5	pharmacognosy	pharmacognosy	NOUN
biomedich-872	192	6	research	research	NOUN
biomedich-872	192	7	,	,	PUNCT
biomedich-872	192	8	13(2	13(2	PROPN
biomedich-872	192	9	)	)	PUNCT
biomedich-872	192	10	,	,	PUNCT
biomedich-872	192	11	565–577	565–577	NUM
biomedich-872	192	12	.	.	PUNCT
biomedich-872	193	1	https://doi.org/10.56499/jppres24.2045_13.2.565	https://doi.org/10.56499/jppres24.2045_13.2.565	ADJ
biomedich-872	193	2	glass	glass	NOUN
biomedich-872	193	3	,	,	PUNCT
biomedich-872	193	4	d.	d.	PROPN
biomedich-872	193	5	s.	s.	PROPN
biomedich-872	193	6	,	,	PUNCT
biomedich-872	193	7	grossfeld	grossfeld	PROPN
biomedich-872	193	8	,	,	PUNCT
biomedich-872	193	9	d.	d.	PROPN
biomedich-872	193	10	,	,	PUNCT
biomedich-872	193	11	renna	renna	PROPN
biomedich-872	193	12	,	,	PUNCT
biomedich-872	193	13	h.	h.	PROPN
biomedich-872	193	14	a.	a.	PROPN
biomedich-872	193	15	,	,	PUNCT
biomedich-872	193	16	agarwala	agarwala	NOUN
biomedich-872	193	17	,	,	PUNCT
biomedich-872	193	18	p.	p.	NOUN
biomedich-872	193	19	,	,	PUNCT
biomedich-872	193	20	spiegler	spiegler	NOUN
biomedich-872	193	21	,	,	PUNCT
biomedich-872	193	22	p.	p.	NOUN
biomedich-872	193	23	,	,	PUNCT
biomedich-872	193	24	deleon	deleon	PROPN
biomedich-872	193	25	,	,	PUNCT
biomedich-872	193	26	j.	j.	PROPN
biomedich-872	193	27	,	,	PUNCT
biomedich-872	193	28	&	&	CCONJ
biomedich-872	193	29	reiss	reiss	PROPN
biomedich-872	193	30	,	,	PUNCT
biomedich-872	193	31	a.	a.	PROPN
biomedich-872	193	32	b.	b.	PROPN
biomedich-872	193	33	(	(	PUNCT
biomedich-872	193	34	2022	2022	NUM
biomedich-872	193	35	)	)	PUNCT
biomedich-872	193	36	.	.	PUNCT
biomedich-872	194	1	idiopathic	idiopathic	ADJ
biomedich-872	194	2	pulmonary	pulmonary	ADJ
biomedich-872	194	3	fibrosis	fibrosis	NOUN
biomedich-872	194	4	:	:	PUNCT
biomedich-872	194	5	current	current	ADJ
biomedich-872	194	6	and	and	CCONJ
biomedich-872	194	7	future	future	ADJ
biomedich-872	194	8	treatment	treatment	NOUN
biomedich-872	194	9	.	.	PUNCT
biomedich-872	195	1	clinical	clinical	ADJ
biomedich-872	195	2	respiratory	respiratory	ADJ
biomedich-872	195	3	journal	journal	NOUN
biomedich-872	195	4	,	,	PUNCT
biomedich-872	195	5	16(2	16(2	NUM
biomedich-872	195	6	)	)	PUNCT
biomedich-872	195	7	,	,	PUNCT
biomedich-872	195	8	84–96	84–96	NUM
biomedich-872	195	9	.	.	PUNCT
biomedich-872	196	1	https://doi.org/10.1111/crj.13466	https://doi.org/10.1111/crj.13466	PROPN
biomedich-872	196	2	imaduddin	imaduddin	PROPN
biomedich-872	196	3	,	,	PUNCT
biomedich-872	196	4	u.	u.	PROPN
biomedich-872	196	5	k.	k.	PROPN
biomedich-872	196	6	,	,	PUNCT
biomedich-872	196	7	berbudi	berbudi	NOUN
biomedich-872	196	8	,	,	PUNCT
biomedich-872	196	9	a.	a.	PROPN
biomedich-872	196	10	,	,	PUNCT
biomedich-872	196	11	&	&	CCONJ
biomedich-872	196	12	rohmawaty	rohmawaty	PROPN
biomedich-872	196	13	,	,	PUNCT
biomedich-872	196	14	e.	e.	PROPN
biomedich-872	196	15	(	(	PUNCT
biomedich-872	196	16	2024	2024	NUM
biomedich-872	196	17	)	)	PUNCT
biomedich-872	196	18	.	.	PUNCT
biomedich-872	197	1	the	the	DET
biomedich-872	197	2	effect	effect	NOUN
biomedich-872	197	3	of	of	ADP
biomedich-872	197	4	physalis	physalis	PROPN
biomedich-872	197	5	angulata	angulata	PROPN
biomedich-872	197	6	l.	l.	PROPN
biomedich-872	197	7	administration	administration	PROPN
biomedich-872	197	8	on	on	ADP
biomedich-872	197	9	gene	gene	NOUN
biomedich-872	197	10	expressions	expression	NOUN
biomedich-872	197	11	related	relate	VERB
biomedich-872	197	12	to	to	ADP
biomedich-872	197	13	lung	lung	NOUN
biomedich-872	197	14	fibrosis	fibrosis	NOUN
biomedich-872	197	15	resolution	resolution	NOUN
biomedich-872	197	16	in	in	ADP
biomedich-872	197	17	miceinduced	miceinduced	ADJ
biomedich-872	197	18	bleomycin	bleomycin	PROPN
biomedich-872	197	19	.	.	PUNCT
biomedich-872	198	1	journal	journal	PROPN
biomedich-872	198	2	of	of	ADP
biomedich-872	198	3	experimental	experimental	ADJ
biomedich-872	198	4	pharmacology	pharmacology	NOUN
biomedich-872	198	5	,	,	PUNCT
biomedich-872	198	6	16	16	NUM
biomedich-872	198	7	,	,	PUNCT
biomedich-872	198	8	49–60	49–60	NUM
biomedich-872	198	9	.	.	NOUN
biomedich-872	199	1	https://doi.org/10.2147/jep.s439932	https://doi.org/10.2147/jep.s439932	NUM
biomedich-872	199	2	kardos	kardo	NOUN
biomedich-872	199	3	,	,	PUNCT
biomedich-872	199	4	p.	p.	NOUN
biomedich-872	199	5	,	,	PUNCT
biomedich-872	199	6	dinh	dinh	PROPN
biomedich-872	199	7	,	,	PUNCT
biomedich-872	199	8	q.	q.	PROPN
biomedich-872	199	9	t.	t.	PROPN
biomedich-872	199	10	,	,	PUNCT
biomedich-872	199	11	fuchs	fuchs	PROPN
biomedich-872	199	12	,	,	PUNCT
biomedich-872	199	13	k.	k.	PROPN
biomedich-872	199	14	h.	h.	PROPN
biomedich-872	199	15	,	,	PUNCT
biomedich-872	199	16	gillissen	gillissen	PROPN
biomedich-872	199	17	,	,	PUNCT
biomedich-872	199	18	a.	a.	PROPN
biomedich-872	199	19	,	,	PUNCT
biomedich-872	199	20	klimek	klimek	PROPN
biomedich-872	199	21	,	,	PUNCT
biomedich-872	199	22	l.	l.	PROPN
biomedich-872	199	23	,	,	PUNCT
biomedich-872	199	24	koehler	koehler	NOUN
biomedich-872	199	25	,	,	PUNCT
biomedich-872	199	26	m.	m.	NOUN
biomedich-872	199	27	,	,	PUNCT
biomedich-872	199	28	sitter	sitter	NOUN
biomedich-872	199	29	,	,	PUNCT
biomedich-872	199	30	h.	h.	PROPN
biomedich-872	199	31	,	,	PUNCT
biomedich-872	199	32	&	&	CCONJ
biomedich-872	199	33	worth	worth	ADJ
biomedich-872	199	34	,	,	PUNCT
biomedich-872	199	35	h.	h.	PROPN
biomedich-872	199	36	(	(	PUNCT
biomedich-872	199	37	2020	2020	NUM
biomedich-872	199	38	)	)	PUNCT
biomedich-872	199	39	.	.	PUNCT
biomedich-872	200	1	german	german	ADJ
biomedich-872	200	2	respiratory	respiratory	ADJ
biomedich-872	200	3	society	society	NOUN
biomedich-872	200	4	guidelines	guideline	NOUN
biomedich-872	200	5	for	for	ADP
biomedich-872	200	6	diagnosis	diagnosis	NOUN
biomedich-872	200	7	and	and	CCONJ
biomedich-872	200	8	treatment	treatment	NOUN
biomedich-872	200	9	of	of	ADP
biomedich-872	200	10	adults	adult	NOUN
biomedich-872	200	11	suffering	suffer	VERB
biomedich-872	200	12	from	from	ADP
biomedich-872	200	13	acute	acute	ADJ
biomedich-872	200	14	,	,	PUNCT
biomedich-872	200	15	subacute	subacute	NOUN
biomedich-872	200	16	and	and	CCONJ
biomedich-872	200	17	chronic	chronic	ADJ
biomedich-872	200	18	cough	cough	NOUN
biomedich-872	200	19	.	.	PUNCT
biomedich-872	201	1	respiratory	respiratory	ADJ
biomedich-872	201	2	medicine	medicine	NOUN
biomedich-872	201	3	,	,	PUNCT
biomedich-872	201	4	170	170	NUM
biomedich-872	201	5	.	.	PUNCT
biomedich-872	202	1	https://doi.org/10.1016/j.rmed.2020.105939	https://doi.org/10.1016/j.rmed.2020.105939	PROPN
biomedich-872	202	2	ke	ke	PROPN
biomedich-872	202	3	,	,	PUNCT
biomedich-872	202	4	b.	b.	PROPN
biomedich-872	202	5	,	,	PUNCT
biomedich-872	202	6	shen	shen	PROPN
biomedich-872	202	7	,	,	PUNCT
biomedich-872	202	8	w.	w.	PROPN
biomedich-872	202	9	,	,	PUNCT
biomedich-872	202	10	fang	fang	PROPN
biomedich-872	202	11	,	,	PUNCT
biomedich-872	202	12	x.	x.	NOUN
biomedich-872	202	13	,	,	PUNCT
biomedich-872	202	14	&	&	CCONJ
biomedich-872	202	15	wu	wu	PROPN
biomedich-872	202	16	,	,	PUNCT
biomedich-872	202	17	q.	q.	PROPN
biomedich-872	202	18	(	(	PUNCT
biomedich-872	202	19	2018	2018	NUM
biomedich-872	202	20	)	)	PUNCT
biomedich-872	202	21	.	.	PUNCT
biomedich-872	203	1	the	the	DET
biomedich-872	203	2	nlpr3	nlpr3	NOUN
biomedich-872	203	3	inflammasome	inflammasome	NOUN
biomedich-872	203	4	and	and	CCONJ
biomedich-872	203	5	obesity	obesity	NOUN
biomedich-872	203	6	-	-	PUNCT
biomedich-872	203	7	related	relate	VERB
biomedich-872	203	8	kidney	kidney	NOUN
biomedich-872	203	9	disease	disease	NOUN
biomedich-872	203	10	.	.	PUNCT
biomedich-872	204	1	in	in	ADP
biomedich-872	204	2	journal	journal	NOUN
biomedich-872	204	3	of	of	ADP
biomedich-872	204	4	cellular	cellular	ADJ
biomedich-872	204	5	and	and	CCONJ
biomedich-872	204	6	molecular	molecular	ADJ
biomedich-872	204	7	medicine	medicine	NOUN
biomedich-872	204	8	(	(	PUNCT
biomedich-872	204	9	vol	vol	NOUN
biomedich-872	204	10	.	.	PROPN
biomedich-872	204	11	22	22	NUM
biomedich-872	204	12	,	,	PUNCT
biomedich-872	204	13	issue	issue	NOUN
biomedich-872	204	14	1	1	NUM
biomedich-872	204	15	,	,	PUNCT
biomedich-872	204	16	pp	pp	ADJ
biomedich-872	204	17	.	.	PUNCT
biomedich-872	205	1	16	16	NUM
biomedich-872	205	2	–	–	PUNCT
biomedich-872	205	3	24	24	NUM
biomedich-872	205	4	)	)	PUNCT
biomedich-872	205	5	.	.	PUNCT
biomedich-872	206	1	blackwell	blackwell	PROPN
biomedich-872	206	2	publishing	publishing	PROPN
biomedich-872	206	3	inc	inc	PROPN
biomedich-872	206	4	.	.	PROPN
biomedich-872	206	5	https://doi.org/10.1111/jcmm.13333	https://doi.org/10.1111/jcmm.13333	PROPN
biomedich-872	206	6	ke	ke	PROPN
biomedich-872	206	7	,	,	PUNCT
biomedich-872	206	8	h.	h.	PROPN
biomedich-872	206	9	l.	l.	PROPN
biomedich-872	206	10	,	,	PUNCT
biomedich-872	206	11	li	li	PROPN
biomedich-872	206	12	,	,	PUNCT
biomedich-872	206	13	r.	r.	PROPN
biomedich-872	206	14	j.	j.	PROPN
biomedich-872	206	15	,	,	PUNCT
biomedich-872	206	16	yu	yu	PROPN
biomedich-872	206	17	,	,	PUNCT
biomedich-872	206	18	c.	c.	PROPN
biomedich-872	206	19	c.	c.	PROPN
biomedich-872	206	20	,	,	PUNCT
biomedich-872	206	21	wang	wang	PROPN
biomedich-872	206	22	,	,	PUNCT
biomedich-872	206	23	x.	x.	PROPN
biomedich-872	206	24	p.	p.	PROPN
biomedich-872	206	25	,	,	PUNCT
biomedich-872	206	26	wu	wu	PROPN
biomedich-872	206	27	,	,	PUNCT
biomedich-872	206	28	c.	c.	PROPN
biomedich-872	206	29	y.	y.	PROPN
biomedich-872	206	30	,	,	PUNCT
biomedich-872	206	31	&	&	CCONJ
biomedich-872	206	32	zhang	zhang	PROPN
biomedich-872	206	33	,	,	PUNCT
biomedich-872	206	34	y.	y.	PROPN
biomedich-872	206	35	w.	w.	PROPN
biomedich-872	206	36	(	(	PUNCT
biomedich-872	206	37	2024	2024	NUM
biomedich-872	206	38	)	)	PUNCT
biomedich-872	206	39	.	.	PUNCT
biomedich-872	207	1	network	network	NOUN
biomedich-872	207	2	pharmacology	pharmacology	NOUN
biomedich-872	207	3	and	and	CCONJ
biomedich-872	207	4	experimental	experimental	ADJ
biomedich-872	207	5	verification	verification	NOUN
biomedich-872	207	6	to	to	PART
biomedich-872	207	7	decode	decode	VERB
biomedich-872	207	8	the	the	DET
biomedich-872	207	9	action	action	NOUN
biomedich-872	207	10	of	of	ADP
biomedich-872	207	11	qing	qing	PROPN
biomedich-872	207	12	fei	fei	PROPN
biomedich-872	207	13	hua	hua	PROPN
biomedich-872	207	14	xian	xian	PROPN
biomedich-872	207	15	decotion	decotion	PROPN
biomedich-872	207	16	against	against	ADP
biomedich-872	207	17	pulmonary	pulmonary	ADJ
biomedich-872	207	18	fibrosis	fibrosis	NOUN
biomedich-872	207	19	.	.	PUNCT
biomedich-872	208	1	plos	plos	PROPN
biomedich-872	208	2	one	one	NUM
biomedich-872	208	3	,	,	PUNCT
biomedich-872	208	4	19(6	19(6	NUM
biomedich-872	208	5	june	june	PROPN
biomedich-872	208	6	)	)	PUNCT
biomedich-872	208	7	.	.	PUNCT
biomedich-872	209	1	https://doi.org/10.1371/journal.pone.0305903	https://doi.org/10.1371/journal.pone.0305903	NOUN
biomedich-872	209	2	kreuter	kreuter	NOUN
biomedich-872	209	3	,	,	PUNCT
biomedich-872	209	4	m.	m.	NOUN
biomedich-872	209	5	,	,	PUNCT
biomedich-872	209	6	müller	müller	PROPN
biomedich-872	209	7	-	-	PUNCT
biomedich-872	209	8	ladner	ladner	PROPN
biomedich-872	209	9	,	,	PUNCT
biomedich-872	209	10	u.	u.	PROPN
biomedich-872	209	11	,	,	PUNCT
biomedich-872	209	12	costabel	costabel	NOUN
biomedich-872	209	13	,	,	PUNCT
biomedich-872	209	14	u.	u.	PROPN
biomedich-872	209	15	,	,	PUNCT
biomedich-872	209	16	jonigk	jonigk	PROPN
biomedich-872	209	17	,	,	PUNCT
biomedich-872	209	18	d.	d.	PROPN
biomedich-872	209	19	,	,	PUNCT
biomedich-872	209	20	&	&	CCONJ
biomedich-872	209	21	heußel	heußel	NOUN
biomedich-872	209	22	,	,	PUNCT
biomedich-872	209	23	c.	c.	PROPN
biomedich-872	209	24	p.	p.	PROPN
biomedich-872	209	25	(	(	PUNCT
biomedich-872	209	26	2021	2021	NUM
biomedich-872	209	27	)	)	PUNCT
biomedich-872	209	28	.	.	PUNCT
biomedich-872	210	1	diagnostik	diagnostik	PROPN
biomedich-872	210	2	und	und	PROPN
biomedich-872	210	3	therapie	therapie	PROPN
biomedich-872	210	4	der	der	PROPN
biomedich-872	210	5	lungenfibrosen	lungenfibrosen	PROPN
biomedich-872	210	6	.	.	PUNCT
biomedich-872	211	1	deutsches	deutsche	NOUN
biomedich-872	211	2	arzteblatt	arzteblatt	PROPN
biomedich-872	211	3	international	international	PROPN
biomedich-872	211	4	,	,	PUNCT
biomedich-872	211	5	118(9	118(9	NUM
biomedich-872	211	6	)	)	PUNCT
biomedich-872	211	7	,	,	PUNCT
biomedich-872	211	8	152–162	152–162	NUM
biomedich-872	211	9	.	.	PUNCT
biomedich-872	212	1	https://doi.org/10.3238/arztebl.m2021.0018	https://doi.org/10.3238/arztebl.m2021.0018	PROPN
biomedich-872	212	2	lee	lee	PROPN
biomedich-872	212	3	,	,	PUNCT
biomedich-872	212	4	j.	j.	PROPN
biomedich-872	212	5	h.	h.	PROPN
biomedich-872	212	6	,	,	PUNCT
biomedich-872	212	7	&	&	CCONJ
biomedich-872	212	8	song	song	PROPN
biomedich-872	212	9	,	,	PUNCT
biomedich-872	212	10	j.	j.	PROPN
biomedich-872	212	11	w.	w.	PROPN
biomedich-872	212	12	(	(	PUNCT
biomedich-872	212	13	2024	2024	NUM
biomedich-872	212	14	)	)	PUNCT
biomedich-872	212	15	.	.	PUNCT
biomedich-872	213	1	diagnostic	diagnostic	ADJ
biomedich-872	213	2	approaches	approach	NOUN
biomedich-872	213	3	for	for	ADP
biomedich-872	213	4	idiopathic	idiopathic	ADJ
biomedich-872	213	5	pulmonary	pulmonary	ADJ
biomedich-872	213	6	fibrosis	fibrosis	NOUN
biomedich-872	213	7	.	.	PUNCT
biomedich-872	214	1	tuberculosis	tuberculosis	NOUN
biomedich-872	214	2	and	and	CCONJ
biomedich-872	214	3	respiratory	respiratory	ADJ
biomedich-872	214	4	diseases	disease	NOUN
biomedich-872	214	5	,	,	PUNCT
biomedich-872	214	6	87(1	87(1	NUM
biomedich-872	214	7	)	)	PUNCT
biomedich-872	214	8	,	,	PUNCT
biomedich-872	214	9	40–51	40–51	NUM
biomedich-872	214	10	.	.	PUNCT
biomedich-872	215	1	https://doi.org/10.4046/trd.2023.0087	https://doi.org/10.4046/trd.2023.0087	PROPN
biomedich-872	215	2	liu	liu	PROPN
biomedich-872	215	3	,	,	PUNCT
biomedich-872	215	4	t.	t.	PROPN
biomedich-872	215	5	,	,	PUNCT
biomedich-872	215	6	xu	xu	PROPN
biomedich-872	215	7	,	,	PUNCT
biomedich-872	215	8	p.	p.	PROPN
biomedich-872	215	9	,	,	PUNCT
biomedich-872	215	10	qi	qi	PROPN
biomedich-872	215	11	,	,	PUNCT
biomedich-872	215	12	s.	s.	PROPN
biomedich-872	215	13	,	,	PUNCT
biomedich-872	215	14	ke	ke	PROPN
biomedich-872	215	15	,	,	PUNCT
biomedich-872	215	16	s.	s.	PROPN
biomedich-872	215	17	,	,	PUNCT
biomedich-872	215	18	hu	hu	PROPN
biomedich-872	215	19	,	,	PUNCT
biomedich-872	215	20	q.	q.	PROPN
biomedich-872	215	21	,	,	PUNCT
biomedich-872	215	22	zhao	zhao	PROPN
biomedich-872	215	23	,	,	PUNCT
biomedich-872	215	24	p.	p.	PROPN
biomedich-872	215	25	,	,	PUNCT
biomedich-872	215	26	&	&	CCONJ
biomedich-872	215	27	li	li	PROPN
biomedich-872	215	28	,	,	PUNCT
biomedich-872	215	29	j.	j.	PROPN
biomedich-872	215	30	(	(	PUNCT
biomedich-872	215	31	2021	2021	NUM
biomedich-872	215	32	)	)	PUNCT
biomedich-872	215	33	.	.	PUNCT
biomedich-872	216	1	network	network	NOUN
biomedich-872	216	2	pharmacology	pharmacology	NOUN
biomedich-872	216	3	-	-	PUNCT
biomedich-872	216	4	based	base	VERB
biomedich-872	216	5	mechanistic	mechanistic	ADJ
biomedich-872	216	6	investigation	investigation	NOUN
biomedich-872	216	7	of	of	ADP
biomedich-872	216	8	jinshui	jinshui	PROPN
biomedich-872	216	9	huanxian	huanxian	ADJ
biomedich-872	216	10	formula	formula	NOUN
biomedich-872	216	11	acting	act	VERB
biomedich-872	216	12	on	on	ADP
biomedich-872	216	13	idiopathic	idiopathic	ADJ
biomedich-872	216	14	pulmonary	pulmonary	ADJ
biomedich-872	216	15	fibrosis	fibrosis	NOUN
biomedich-872	216	16	.	.	PUNCT
biomedich-872	217	1	evidence	evidence	NOUN
biomedich-872	217	2	-	-	PUNCT
biomedich-872	217	3	based	base	VERB
biomedich-872	217	4	complementary	complementary	ADJ
biomedich-872	217	5	and	and	CCONJ
biomedich-872	217	6	alternative	alternative	ADJ
biomedich-872	217	7	medicine	medicine	NOUN
biomedich-872	217	8	,	,	PUNCT
biomedich-872	217	9	2021	2021	NUM
biomedich-872	217	10	.	.	PUNCT
biomedich-872	218	1	https://doi.org/10.1155/2021/8634705	https://doi.org/10.1155/2021/8634705	PROPN
biomedich-872	218	2	martinez	martinez	PROPN
biomedich-872	218	3	,	,	PUNCT
biomedich-872	218	4	f.	f.	PROPN
biomedich-872	218	5	j.	j.	PROPN
biomedich-872	218	6	,	,	PUNCT
biomedich-872	218	7	collard	collard	PROPN
biomedich-872	218	8	,	,	PUNCT
biomedich-872	218	9	h.	h.	PROPN
biomedich-872	218	10	r.	r.	PROPN
biomedich-872	218	11	,	,	PUNCT
biomedich-872	218	12	pardo	pardo	PROPN
biomedich-872	218	13	,	,	PUNCT
biomedich-872	218	14	a.	a.	PROPN
biomedich-872	218	15	,	,	PUNCT
biomedich-872	218	16	raghu	raghu	PROPN
biomedich-872	218	17	,	,	PUNCT
biomedich-872	218	18	g.	g.	PROPN
biomedich-872	218	19	,	,	PUNCT
biomedich-872	218	20	richeldi	richeldi	PROPN
biomedich-872	218	21	,	,	PUNCT
biomedich-872	218	22	l.	l.	PROPN
biomedich-872	218	23	,	,	PUNCT
biomedich-872	218	24	selman	selman	PROPN
biomedich-872	218	25	,	,	PUNCT
biomedich-872	218	26	m.	m.	NOUN
biomedich-872	218	27	,	,	PUNCT
biomedich-872	218	28	swigris	swigris	PROPN
biomedich-872	218	29	,	,	PUNCT
biomedich-872	218	30	j.	j.	PROPN
biomedich-872	218	31	j.	j.	PROPN
biomedich-872	218	32	,	,	PUNCT
biomedich-872	218	33	taniguchi	taniguchi	PROPN
biomedich-872	218	34	,	,	PUNCT
biomedich-872	218	35	h.	h.	PROPN
biomedich-872	218	36	,	,	PUNCT
biomedich-872	218	37	&	&	CCONJ
biomedich-872	218	38	wells	wells	PROPN
biomedich-872	218	39	,	,	PUNCT
biomedich-872	218	40	a.	a.	PROPN
biomedich-872	218	41	u.	u.	PROPN
biomedich-872	218	42	(	(	PUNCT
biomedich-872	218	43	2017	2017	NUM
biomedich-872	218	44	)	)	PUNCT
biomedich-872	218	45	.	.	PUNCT
biomedich-872	219	1	idiopathic	idiopathic	ADJ
biomedich-872	219	2	pulmonary	pulmonary	ADJ
biomedich-872	219	3	fibrosis	fibrosis	NOUN
biomedich-872	219	4	.	.	PUNCT
biomedich-872	220	1	nature	nature	NOUN
biomedich-872	220	2	reviews	review	NOUN
biomedich-872	220	3	disease	disease	NOUN
biomedich-872	220	4	primers	primer	NOUN
biomedich-872	220	5	,	,	PUNCT
biomedich-872	220	6	3	3	X
biomedich-872	220	7	.	.	PUNCT
biomedich-872	221	1	https://doi.org/10.1038/nrdp.2017.74	https://doi.org/10.1038/nrdp.2017.74	ADJ
biomedich-872	221	2	mazurek	mazurek	NOUN
biomedich-872	221	3	,	,	PUNCT
biomedich-872	221	4	j.	j.	PROPN
biomedich-872	221	5	m.	m.	PROPN
biomedich-872	221	6	,	,	PUNCT
biomedich-872	221	7	syamlal	syamlal	PROPN
biomedich-872	221	8	,	,	PUNCT
biomedich-872	221	9	g.	g.	PROPN
biomedich-872	221	10	,	,	PUNCT
biomedich-872	221	11	&	&	CCONJ
biomedich-872	221	12	weissman	weissman	PROPN
biomedich-872	221	13	,	,	PUNCT
biomedich-872	221	14	d.	d.	PROPN
biomedich-872	221	15	n.	n.	PROPN
biomedich-872	221	16	(	(	PUNCT
biomedich-872	221	17	2025	2025	NUM
biomedich-872	221	18	)	)	PUNCT
biomedich-872	221	19	.	.	PUNCT
biomedich-872	222	1	morbidity	morbidity	NOUN
biomedich-872	222	2	and	and	CCONJ
biomedich-872	222	3	mortality	mortality	NOUN
biomedich-872	222	4	weekly	weekly	ADJ
biomedich-872	222	5	report	report	VERB
biomedich-872	222	6	idiopathic	idiopathic	ADJ
biomedich-872	222	7	pulmonary	pulmonary	ADJ
biomedich-872	222	8	fibrosis	fibrosis	NOUN
biomedich-872	222	9	mortality	mortality	NOUN
biomedich-872	222	10	by	by	ADP
biomedich-872	222	11	industry	industry	NOUN
biomedich-872	222	12	and	and	CCONJ
biomedich-872	222	13	occupation	occupation	NOUN
biomedich-872	222	14	-	-	PUNCT
biomedich-872	222	15	united	unite	VERB
biomedich-872	222	16	states	states	PROPN
biomedich-872	222	17	,	,	PUNCT
biomedich-872	222	18	2020	2020	NUM
biomedich-872	222	19	-	-	SYM
biomedich-872	222	20	2022	2022	NUM
biomedich-872	222	21	.	.	PUNCT
biomedich-872	223	1	morbidity	morbidity	NOUN
biomedich-872	223	2	and	and	CCONJ
biomedich-872	223	3	mortality	mortality	NOUN
biomedich-872	223	4	weekly	weekly	ADJ
biomedich-872	223	5	report	report	NOUN
biomedich-872	223	6	,	,	PUNCT
biomedich-872	223	7	74(7	74(7	NOUN
biomedich-872	223	8	)	)	PUNCT
biomedich-872	223	9	.	.	PUNCT
biomedich-872	224	1	https://www.cdc.gov/mmwr/mmwr_continuingeducation.html	https://www.cdc.gov/mmwr/mmwr_continuingeducation.html	PROPN
biomedich-872	224	2	nguyen	nguyen	NOUN
biomedich-872	224	3	,	,	PUNCT
biomedich-872	224	4	k.	k.	PROPN
biomedich-872	224	5	n.	n.	PROPN
biomedich-872	224	6	h.	h.	PROPN
biomedich-872	224	7	,	,	PUNCT
biomedich-872	224	8	nguyen	nguyen	PROPN
biomedich-872	224	9	,	,	PUNCT
biomedich-872	224	10	n.	n.	NOUN
biomedich-872	224	11	v.	v.	PROPN
biomedich-872	224	12	t.	t.	PROPN
biomedich-872	224	13	,	,	PUNCT
biomedich-872	224	14	&	&	CCONJ
biomedich-872	224	15	kim	kim	PROPN
biomedich-872	224	16	,	,	PUNCT
biomedich-872	224	17	k.	k.	PROPN
biomedich-872	224	18	h.	h.	PROPN
biomedich-872	224	19	(	(	PUNCT
biomedich-872	224	20	2021	2021	NUM
biomedich-872	224	21	)	)	PUNCT
biomedich-872	224	22	.	.	PUNCT
biomedich-872	225	1	determination	determination	NOUN
biomedich-872	225	2	of	of	ADP
biomedich-872	225	3	phenolic	phenolic	ADJ
biomedich-872	225	4	acids	acid	NOUN
biomedich-872	225	5	and	and	CCONJ
biomedich-872	225	6	flavonoids	flavonoid	NOUN
biomedich-872	225	7	in	in	ADP
biomedich-872	225	8	leaves	leave	NOUN
biomedich-872	225	9	,	,	PUNCT
biomedich-872	225	10	calyces	calyx	NOUN
biomedich-872	225	11	,	,	PUNCT
biomedich-872	225	12	and	and	CCONJ
biomedich-872	225	13	fruits	fruit	NOUN
biomedich-872	225	14	of	of	ADP
biomedich-872	225	15	physalis	physali	NOUN
biomedich-872	225	16	angulata	angulata	VERB
biomedich-872	225	17	l.	l.	PROPN
biomedich-872	225	18	in	in	ADP
biomedich-872	225	19	viet	viet	PROPN
biomedich-872	225	20	nam	nam	PROPN
biomedich-872	225	21	.	.	PUNCT
biomedich-872	226	1	pharmacia	pharmacia	PROPN
biomedich-872	226	2	,	,	PUNCT
biomedich-872	226	3	68(2	68(2	NOUN
biomedich-872	226	4	)	)	PUNCT
biomedich-872	226	5	,	,	PUNCT
biomedich-872	226	6	501–509	501–509	NUM
biomedich-872	226	7	.	.	PUNCT
biomedich-872	227	1	https://doi.org/10.3897/pharmacia.68.e66044	https://doi.org/10.3897/pharmacia.68.e66044	PROPN
biomedich-872	227	2	nogales	nogales	PROPN
biomedich-872	227	3	,	,	PUNCT
biomedich-872	227	4	c.	c.	NOUN
biomedich-872	227	5	,	,	PUNCT
biomedich-872	227	6	mamdouh	mamdouh	NOUN
biomedich-872	227	7	,	,	PUNCT
biomedich-872	227	8	z.	z.	PROPN
biomedich-872	227	9	m.	m.	PROPN
biomedich-872	227	10	,	,	PUNCT
biomedich-872	227	11	list	list	NOUN
biomedich-872	227	12	,	,	PUNCT
biomedich-872	227	13	m.	m.	NOUN
biomedich-872	227	14	,	,	PUNCT
biomedich-872	227	15	kiel	kiel	PROPN
biomedich-872	227	16	,	,	PUNCT
biomedich-872	227	17	c.	c.	PROPN
biomedich-872	227	18	,	,	PUNCT
biomedich-872	227	19	casas	casas	PROPN
biomedich-872	227	20	,	,	PUNCT
biomedich-872	227	21	a.	a.	NOUN
biomedich-872	227	22	i.	i.	PROPN
biomedich-872	227	23	,	,	PUNCT
biomedich-872	227	24	&	&	CCONJ
biomedich-872	227	25	schmidt	schmidt	PROPN
biomedich-872	227	26	,	,	PUNCT
biomedich-872	227	27	h.	h.	PROPN
biomedich-872	227	28	h.	h.	PROPN
biomedich-872	227	29	h.	h.	PROPN
biomedich-872	227	30	w.	w.	PROPN
biomedich-872	227	31	(	(	PUNCT
biomedich-872	227	32	2022	2022	NUM
biomedich-872	227	33	)	)	PUNCT
biomedich-872	227	34	.	.	PUNCT
biomedich-872	228	1	network	network	NOUN
biomedich-872	228	2	pharmacology	pharmacology	NOUN
biomedich-872	228	3	:	:	PUNCT
biomedich-872	228	4	curing	cure	VERB
biomedich-872	228	5	causal	causal	ADJ
biomedich-872	228	6	mechanisms	mechanism	NOUN
biomedich-872	228	7	instead	instead	ADV
biomedich-872	228	8	of	of	ADP
biomedich-872	228	9	treating	treat	VERB
biomedich-872	228	10	symptoms	symptom	NOUN
biomedich-872	228	11	.	.	PUNCT
biomedich-872	229	1	trends	trend	NOUN
biomedich-872	229	2	in	in	ADP
biomedich-872	229	3	pharmacological	pharmacological	ADJ
biomedich-872	229	4	sciences	science	NOUN
biomedich-872	229	5	,	,	PUNCT
biomedich-872	229	6	43(2	43(2	NUM
biomedich-872	229	7	)	)	PUNCT
biomedich-872	229	8	,	,	PUNCT
biomedich-872	229	9	136–150	136–150	NUM
biomedich-872	229	10	.	.	PUNCT
biomedich-872	230	1	https://doi.org/10.1016/j.tips.2021.11.004	https://doi.org/10.1016/j.tips.2021.11.004	PROPN
biomedich-872	230	2	novitasari	novitasari	PROPN
biomedich-872	230	3	,	,	PUNCT
biomedich-872	230	4	a.	a.	PROPN
biomedich-872	230	5	,	,	PUNCT
biomedich-872	230	6	rohmawaty	rohmawaty	PROPN
biomedich-872	230	7	,	,	PUNCT
biomedich-872	230	8	e.	e.	PROPN
biomedich-872	230	9	,	,	PUNCT
biomedich-872	230	10	&	&	CCONJ
biomedich-872	230	11	rosdianto	rosdianto	NOUN
biomedich-872	230	12	,	,	PUNCT
biomedich-872	230	13	a.	a.	NOUN
biomedich-872	230	14	m.	m.	NOUN
biomedich-872	230	15	(	(	PUNCT
biomedich-872	230	16	2024	2024	NUM
biomedich-872	230	17	)	)	PUNCT
biomedich-872	230	18	.	.	PUNCT
biomedich-872	231	1	physalis	physalis	PROPN
biomedich-872	231	2	angulata	angulata	PROPN
biomedich-872	231	3	linn	linn	PROPN
biomedich-872	231	4	.	.	PUNCT
biomedich-872	232	1	as	as	ADP
biomedich-872	232	2	a	a	DET
biomedich-872	232	3	medicinal	medicinal	ADJ
biomedich-872	232	4	plant	plant	NOUN
biomedich-872	232	5	(	(	PUNCT
biomedich-872	232	6	review	review	NOUN
biomedich-872	232	7	)	)	PUNCT
biomedich-872	232	8	.	.	PUNCT
biomedich-872	233	1	biomedical	biomedical	ADJ
biomedich-872	233	2	reports	report	NOUN
biomedich-872	233	3	,	,	PUNCT
biomedich-872	233	4	20(3	20(3	NOUN
biomedich-872	233	5	)	)	PUNCT
biomedich-872	233	6	.	.	PUNCT
biomedich-872	234	1	https://doi.org/10.3892/br.2024.1735	https://doi.org/10.3892/br.2024.1735	VERB
biomedich-872	234	2	824	824	NUM
biomedich-872	234	3	biology	biology	NOUN
biomedich-872	234	4	,	,	PUNCT
biomedich-872	234	5	medicine	medicine	NOUN
biomedich-872	234	6	,	,	PUNCT
biomedich-872	234	7	&	&	CCONJ
biomedich-872	234	8	natural	natural	ADJ
biomedich-872	234	9	product	product	NOUN
biomedich-872	234	10	chemistry	chemistry	NOUN
biomedich-872	234	11	14	14	NUM
biomedich-872	234	12	(	(	PUNCT
biomedich-872	234	13	2	2	NUM
biomedich-872	234	14	)	)	PUNCT
biomedich-872	234	15	,	,	PUNCT
biomedich-872	234	16	2025	2025	NUM
biomedich-872	234	17	:	:	PUNCT
biomedich-872	234	18	817	817	NUM
biomedich-872	234	19	-	-	SYM
biomedich-872	234	20	824	824	NUM
biomedich-872	234	21	pillai	pillai	NOUN
biomedich-872	234	22	,	,	PUNCT
biomedich-872	234	23	j.	j.	PROPN
biomedich-872	234	24	r.	r.	PROPN
biomedich-872	234	25	,	,	PUNCT
biomedich-872	234	26	wali	wali	PROPN
biomedich-872	234	27	,	,	PUNCT
biomedich-872	234	28	a.	a.	PROPN
biomedich-872	234	29	f.	f.	PROPN
biomedich-872	234	30	,	,	PUNCT
biomedich-872	234	31	menezes	menezes	PROPN
biomedich-872	234	32	,	,	PUNCT
biomedich-872	234	33	g.	g.	PROPN
biomedich-872	234	34	a.	a.	PROPN
biomedich-872	234	35	,	,	PUNCT
biomedich-872	234	36	rehman	rehman	PROPN
biomedich-872	234	37	,	,	PUNCT
biomedich-872	234	38	m.	m.	NOUN
biomedich-872	234	39	u.	u.	PROPN
biomedich-872	234	40	,	,	PUNCT
biomedich-872	234	41	wani	wani	PROPN
biomedich-872	234	42	,	,	PUNCT
biomedich-872	234	43	t.	t.	PROPN
biomedich-872	234	44	a.	a.	NOUN
biomedich-872	234	45	,	,	PUNCT
biomedich-872	234	46	arafah	arafah	VERB
biomedich-872	234	47	,	,	PUNCT
biomedich-872	234	48	a.	a.	NOUN
biomedich-872	234	49	,	,	PUNCT
biomedich-872	234	50	zargar	zargar	NOUN
biomedich-872	234	51	,	,	PUNCT
biomedich-872	234	52	s.	s.	PROPN
biomedich-872	234	53	,	,	PUNCT
biomedich-872	234	54	&	&	CCONJ
biomedich-872	234	55	mir	mir	PROPN
biomedich-872	234	56	,	,	PUNCT
biomedich-872	234	57	t.	t.	NOUN
biomedich-872	234	58	m.	m.	NOUN
biomedich-872	234	59	(	(	PUNCT
biomedich-872	234	60	2022	2022	NUM
biomedich-872	234	61	)	)	PUNCT
biomedich-872	234	62	.	.	PUNCT
biomedich-872	235	1	chemical	chemical	ADJ
biomedich-872	235	2	composition	composition	NOUN
biomedich-872	235	3	analysis	analysis	NOUN
biomedich-872	235	4	,	,	PUNCT
biomedich-872	235	5	cytotoxic	cytotoxic	ADJ
biomedich-872	235	6	,	,	PUNCT
biomedich-872	235	7	antimicrobial	antimicrobial	ADJ
biomedich-872	235	8	and	and	CCONJ
biomedich-872	235	9	antioxidant	antioxidant	ADJ
biomedich-872	235	10	activities	activity	NOUN
biomedich-872	235	11	of	of	ADP
biomedich-872	235	12	physalis	physali	NOUN
biomedich-872	235	13	angulata	angulata	PROPN
biomedich-872	235	14	l.	l.	PROPN
biomedich-872	235	15	:	:	PUNCT
biomedich-872	235	16	a	a	DET
biomedich-872	235	17	comparative	comparative	ADJ
biomedich-872	235	18	study	study	NOUN
biomedich-872	235	19	of	of	ADP
biomedich-872	235	20	leaves	leave	NOUN
biomedich-872	235	21	and	and	CCONJ
biomedich-872	235	22	fruit	fruit	NOUN
biomedich-872	235	23	.	.	PUNCT
biomedich-872	236	1	molecules	molecule	NOUN
biomedich-872	236	2	,	,	PUNCT
biomedich-872	236	3	27(5	27(5	NOUN
biomedich-872	236	4	)	)	PUNCT
biomedich-872	236	5	.	.	PUNCT
biomedich-872	237	1	https://doi.org/10.3390/molecules27051480	https://doi.org/10.3390/molecules27051480	NOUN
biomedich-872	237	2	prasetyo	prasetyo	NOUN
biomedich-872	237	3	,	,	PUNCT
biomedich-872	237	4	y.	y.	PROPN
biomedich-872	237	5	c.	c.	PROPN
biomedich-872	237	6	,	,	PUNCT
biomedich-872	237	7	&	&	CCONJ
biomedich-872	237	8	purwanti	purwanti	PROPN
biomedich-872	237	9	,	,	PUNCT
biomedich-872	237	10	n.	n.	PROPN
biomedich-872	237	11	(	(	PUNCT
biomedich-872	237	12	2024	2024	NUM
biomedich-872	237	13	)	)	PUNCT
biomedich-872	237	14	.	.	PUNCT
biomedich-872	238	1	ciplukan	ciplukan	PROPN
biomedich-872	238	2	’s	’s	PART
biomedich-872	238	3	antiinflammatory	antiinflammatory	NOUN
biomedich-872	238	4	effects	effect	NOUN
biomedich-872	238	5	:	:	PUNCT
biomedich-872	238	6	mechanisms	mechanism	NOUN
biomedich-872	238	7	uncovered	uncover	VERB
biomedich-872	238	8	.	.	PUNCT
biomedich-872	239	1	berkala	berkala	PROPN
biomedich-872	239	2	ilmiah	ilmiah	PROPN
biomedich-872	239	3	kedokteran	kedokteran	PROPN
biomedich-872	239	4	duta	duta	PROPN
biomedich-872	239	5	wacana	wacana	PROPN
biomedich-872	239	6	,	,	PUNCT
biomedich-872	239	7	9(1	9(1	NUM
biomedich-872	239	8	)	)	PUNCT
biomedich-872	239	9	.	.	PUNCT
biomedich-872	240	1	https://doi.org/10.21460/bikdw.v9i1.656	https://doi.org/10.21460/bikdw.v9i1.656	PROPN
biomedich-872	240	2	rohmawaty	rohmawaty	NOUN
biomedich-872	240	3	,	,	PUNCT
biomedich-872	240	4	e.	e.	PROPN
biomedich-872	240	5	,	,	PUNCT
biomedich-872	240	6	dewi	dewi	PROPN
biomedich-872	240	7	,	,	PUNCT
biomedich-872	240	8	s.	s.	PROPN
biomedich-872	240	9	,	,	PUNCT
biomedich-872	240	10	rosdianto	rosdianto	NOUN
biomedich-872	240	11	,	,	PUNCT
biomedich-872	240	12	a.	a.	NOUN
biomedich-872	240	13	m.	m.	NOUN
biomedich-872	240	14	,	,	PUNCT
biomedich-872	240	15	usman	usman	PROPN
biomedich-872	240	16	,	,	PUNCT
biomedich-872	240	17	h.	h.	PROPN
biomedich-872	240	18	a.	a.	PROPN
biomedich-872	240	19	,	,	PUNCT
biomedich-872	240	20	zuhrotun	zuhrotun	PROPN
biomedich-872	240	21	,	,	PUNCT
biomedich-872	240	22	a.	a.	NOUN
biomedich-872	240	23	,	,	PUNCT
biomedich-872	240	24	hendriani	hendriani	PROPN
biomedich-872	240	25	,	,	PUNCT
biomedich-872	240	26	r.	r.	PROPN
biomedich-872	240	27	,	,	PUNCT
biomedich-872	240	28	wardhana	wardhana	PROPN
biomedich-872	240	29	,	,	PUNCT
biomedich-872	240	30	y.	y.	PROPN
biomedich-872	240	31	w.	w.	PROPN
biomedich-872	240	32	,	,	PUNCT
biomedich-872	240	33	ekawardhani	ekawardhani	PROPN
biomedich-872	240	34	,	,	PUNCT
biomedich-872	240	35	s.	s.	PROPN
biomedich-872	240	36	,	,	PUNCT
biomedich-872	240	37	wiraswati	wiraswati	PROPN
biomedich-872	240	38	,	,	PUNCT
biomedich-872	240	39	h.	h.	PROPN
biomedich-872	240	40	l.	l.	PROPN
biomedich-872	240	41	,	,	PUNCT
biomedich-872	240	42	rahmadi	rahmadi	NOUN
biomedich-872	240	43	,	,	PUNCT
biomedich-872	240	44	a.	a.	PROPN
biomedich-872	240	45	r.	r.	PROPN
biomedich-872	240	46	,	,	PUNCT
biomedich-872	240	47	agustanti	agustanti	PROPN
biomedich-872	240	48	,	,	PUNCT
biomedich-872	240	49	n.	n.	NOUN
biomedich-872	240	50	,	,	PUNCT
biomedich-872	240	51	&	&	CCONJ
biomedich-872	240	52	begawan	begawan	PROPN
biomedich-872	240	53	bestari	bestari	PROPN
biomedich-872	240	54	,	,	PUNCT
biomedich-872	240	55	m.	m.	NOUN
biomedich-872	240	56	(	(	PUNCT
biomedich-872	240	57	2023	2023	NUM
biomedich-872	240	58	)	)	PUNCT
biomedich-872	240	59	.	.	PUNCT
biomedich-872	241	1	ciplukan	ciplukan	PROPN
biomedich-872	241	2	(	(	PUNCT
biomedich-872	241	3	physalis	physalis	NOUN
biomedich-872	241	4	angulata	angulata	PROPN
biomedich-872	241	5	linn	linn	PROPN
biomedich-872	241	6	.	.	PUNCT
biomedich-872	241	7	)	)	PUNCT
biomedich-872	241	8	extract	extract	VERB
biomedich-872	241	9	potential	potential	NOUN
biomedich-872	241	10	on	on	ADP
biomedich-872	241	11	high	high	ADJ
biomedich-872	241	12	-	-	PUNCT
biomedich-872	241	13	fat	fat	NOUN
biomedich-872	241	14	diet	diet	NOUN
biomedich-872	241	15	-	-	PUNCT
biomedich-872	241	16	induced	induce	VERB
biomedich-872	241	17	nonalcoholic	nonalcoholic	NOUN
biomedich-872	241	18	fatty	fatty	NOUN
biomedich-872	241	19	liver	liver	NOUN
biomedich-872	241	20	disease	disease	NOUN
biomedich-872	241	21	(	(	PUNCT
biomedich-872	241	22	nafld	nafld	ADV
biomedich-872	241	23	)	)	PUNCT
biomedich-872	241	24	for	for	ADP
biomedich-872	241	25	liver	liver	NOUN
biomedich-872	241	26	anti	anti	ADJ
biomedich-872	241	27	-	-	ADJ
biomedich-872	241	28	fibrotic	fibrotic	ADJ
biomedich-872	241	29	drug	drug	NOUN
biomedich-872	241	30	development	development	NOUN
biomedich-872	241	31	.	.	PUNCT
biomedich-872	242	1	indonesian	indonesian	ADJ
biomedich-872	242	2	journal	journal	PROPN
biomedich-872	242	3	of	of	ADP
biomedich-872	242	4	pharmacy	pharmacy	NOUN
biomedich-872	242	5	,	,	PUNCT
biomedich-872	242	6	34(4	34(4	NUM
biomedich-872	242	7	)	)	PUNCT
biomedich-872	242	8	,	,	PUNCT
biomedich-872	242	9	582–592	582–592	NUM
biomedich-872	242	10	.	.	PUNCT
biomedich-872	242	11	rohmawaty	rohmawaty	PROPN
biomedich-872	242	12	,	,	PUNCT
biomedich-872	242	13	e.	e.	PROPN
biomedich-872	242	14	,	,	PUNCT
biomedich-872	242	15	rosdianto	rosdianto	NOUN
biomedich-872	242	16	,	,	PUNCT
biomedich-872	242	17	a.	a.	NOUN
biomedich-872	242	18	m.	m.	NOUN
biomedich-872	242	19	,	,	PUNCT
biomedich-872	242	20	usman	usman	PROPN
biomedich-872	242	21	,	,	PUNCT
biomedich-872	242	22	h.	h.	PROPN
biomedich-872	242	23	a.	a.	PROPN
biomedich-872	242	24	,	,	PUNCT
biomedich-872	242	25	saragih	saragih	PROPN
biomedich-872	242	26	,	,	PUNCT
biomedich-872	242	27	w.	w.	PROPN
biomedich-872	242	28	a.	a.	NOUN
biomedich-872	242	29	m.	m.	PROPN
biomedich-872	242	30	,	,	PUNCT
biomedich-872	242	31	zuhrotun	zuhrotun	PROPN
biomedich-872	242	32	,	,	PUNCT
biomedich-872	242	33	a.	a.	NOUN
biomedich-872	242	34	,	,	PUNCT
biomedich-872	242	35	hendriani	hendriani	PROPN
biomedich-872	242	36	,	,	PUNCT
biomedich-872	242	37	r.	r.	PROPN
biomedich-872	242	38	,	,	PUNCT
biomedich-872	242	39	wardhana	wardhana	PROPN
biomedich-872	242	40	,	,	PUNCT
biomedich-872	242	41	y.	y.	PROPN
biomedich-872	242	42	w.	w.	PROPN
biomedich-872	242	43	,	,	PUNCT
biomedich-872	242	44	ekawardhani	ekawardhani	PROPN
biomedich-872	242	45	,	,	PUNCT
biomedich-872	242	46	s.	s.	PROPN
biomedich-872	242	47	,	,	PUNCT
biomedich-872	242	48	wiraswati	wiraswati	PROPN
biomedich-872	242	49	,	,	PUNCT
biomedich-872	242	50	h.	h.	PROPN
biomedich-872	242	51	l.	l.	PROPN
biomedich-872	242	52	,	,	PUNCT
biomedich-872	242	53	agustanti	agustanti	PROPN
biomedich-872	242	54	,	,	PUNCT
biomedich-872	242	55	n.	n.	NOUN
biomedich-872	242	56	,	,	PUNCT
biomedich-872	242	57	bestari	bestari	PROPN
biomedich-872	242	58	,	,	PUNCT
biomedich-872	242	59	m.	m.	PROPN
biomedich-872	242	60	b.	b.	PROPN
biomedich-872	242	61	,	,	PUNCT
biomedich-872	242	62	&	&	CCONJ
biomedich-872	242	63	dewi	dewi	PROPN
biomedich-872	242	64	,	,	PUNCT
biomedich-872	242	65	s.	s.	PROPN
biomedich-872	242	66	(	(	PUNCT
biomedich-872	242	67	2021	2021	NUM
biomedich-872	242	68	)	)	PUNCT
biomedich-872	242	69	.	.	PUNCT
biomedich-872	243	1	antifibrotic	antifibrotic	ADJ
biomedich-872	243	2	effect	effect	NOUN
biomedich-872	243	3	of	of	ADP
biomedich-872	243	4	the	the	DET
biomedich-872	243	5	ethyl	ethyl	PROPN
biomedich-872	243	6	acetate	acetate	PROPN
biomedich-872	243	7	fraction	fraction	NOUN
biomedich-872	243	8	of	of	ADP
biomedich-872	243	9	ciplukan	ciplukan	PROPN
biomedich-872	243	10	(	(	PUNCT
biomedich-872	243	11	physalis	physalis	NOUN
biomedich-872	243	12	angulata	angulata	PROPN
biomedich-872	243	13	linn	linn	PROPN
biomedich-872	243	14	.	.	PUNCT
biomedich-872	243	15	)	)	PUNCT
biomedich-872	244	1	in	in	ADP
biomedich-872	244	2	rat	rat	NOUN
biomedich-872	244	3	liver	liver	NOUN
biomedich-872	244	4	fibrosis	fibrosis	NOUN
biomedich-872	244	5	induced	induce	VERB
biomedich-872	244	6	by	by	ADP
biomedich-872	244	7	cci4	cci4	PROPN
biomedich-872	244	8	.	.	PUNCT
biomedich-872	245	1	journal	journal	PROPN
biomedich-872	245	2	of	of	ADP
biomedich-872	245	3	applied	apply	VERB
biomedich-872	245	4	pharmaceutical	pharmaceutical	ADJ
biomedich-872	245	5	science	science	NOUN
biomedich-872	245	6	,	,	PUNCT
biomedich-872	245	7	11(12	11(12	NUM
biomedich-872	245	8	)	)	PUNCT
biomedich-872	245	9	,	,	PUNCT
biomedich-872	245	10	175–182	175–182	NUM
biomedich-872	245	11	.	.	PUNCT
biomedich-872	246	1	https://doi.org/10.7324/japs.2021.1101217	https://doi.org/10.7324/japs.2021.1101217	PROPN
biomedich-872	246	2	utami	utami	NOUN
biomedich-872	246	3	,	,	PUNCT
biomedich-872	246	4	d.	d.	PROPN
biomedich-872	246	5	,	,	PUNCT
biomedich-872	246	6	elmaningtyas	elmaningtyas	PROPN
biomedich-872	246	7	zahro	zahro	PROPN
biomedich-872	246	8	,	,	PUNCT
biomedich-872	246	9	t.	t.	PROPN
biomedich-872	246	10	,	,	PUNCT
biomedich-872	246	11	nisa	nisa	PROPN
biomedich-872	246	12	,	,	PUNCT
biomedich-872	246	13	k.	k.	PROPN
biomedich-872	246	14	,	,	PUNCT
biomedich-872	246	15	&	&	CCONJ
biomedich-872	246	16	farid	farid	PROPN
biomedich-872	246	17	,	,	PUNCT
biomedich-872	246	18	m.	m.	NOUN
biomedich-872	246	19	(	(	PUNCT
biomedich-872	246	20	2025	2025	NUM
biomedich-872	246	21	)	)	PUNCT
biomedich-872	246	22	.	.	PUNCT
biomedich-872	247	1	in	in	ADP
biomedich-872	247	2	silico	silico	NOUN
biomedich-872	247	3	study	study	NOUN
biomedich-872	247	4	:	:	PUNCT
biomedich-872	247	5	the	the	DET
biomedich-872	247	6	potential	potential	NOUN
biomedich-872	247	7	of	of	ADP
biomedich-872	247	8	kilemo	kilemo	NOUN
biomedich-872	247	9	(	(	PUNCT
biomedich-872	247	10	litsea	litsea	NOUN
biomedich-872	247	11	cubeba	cubeba	PROPN
biomedich-872	247	12	)	)	PUNCT
biomedich-872	247	13	endemic	endemic	ADJ
biomedich-872	247	14	plant	plant	NOUN
biomedich-872	247	15	from	from	ADP
biomedich-872	247	16	kalimantan	kalimantan	PROPN
biomedich-872	247	17	as	as	ADP
biomedich-872	247	18	anti	anti	ADJ
biomedich-872	247	19	-	-	ADJ
biomedich-872	247	20	breast	breast	ADJ
biomedich-872	247	21	cancer	cancer	NOUN
biomedich-872	247	22	through	through	ADP
biomedich-872	247	23	her2	her2	NOUN
biomedich-872	247	24	inhibition	inhibition	NOUN
biomedich-872	247	25	.	.	PUNCT
biomedich-872	248	1	jurnal	jurnal	ADJ
biomedich-872	248	2	ilmiah	ilmiah	PROPN
biomedich-872	248	3	ibnu	ibnu	PROPN
biomedich-872	248	4	sina	sina	PROPN
biomedich-872	248	5	,	,	PUNCT
biomedich-872	248	6	10(1	10(1	NUM
biomedich-872	248	7	)	)	PUNCT
biomedich-872	248	8	,	,	PUNCT
biomedich-872	248	9	167	167	NUM
biomedich-872	248	10	–	–	SYM
biomedich-872	248	11	181	181	NUM
biomedich-872	248	12	.	.	PUNCT
biomedich-872	249	1	https://doi.org/10.36387/jiis.v9i2.2352	https://doi.org/10.36387/jiis.v9i2.2352	ADJ
biomedich-872	249	2	vithalkar	vithalkar	NOUN
biomedich-872	249	3	,	,	PUNCT
biomedich-872	249	4	m.	m.	PROPN
biomedich-872	249	5	p.	p.	PROPN
biomedich-872	249	6	,	,	PUNCT
biomedich-872	249	7	sandra	sandra	PROPN
biomedich-872	249	8	,	,	PUNCT
biomedich-872	249	9	k.	k.	PROPN
biomedich-872	249	10	s.	s.	PROPN
biomedich-872	249	11	,	,	PUNCT
biomedich-872	249	12	bharath	bharath	PROPN
biomedich-872	249	13	,	,	PUNCT
biomedich-872	249	14	h.	h.	PROPN
biomedich-872	249	15	b.	b.	PROPN
biomedich-872	249	16	,	,	PUNCT
biomedich-872	249	17	krishnaprasad	krishnaprasad	PROPN
biomedich-872	249	18	,	,	PUNCT
biomedich-872	249	19	b.	b.	PROPN
biomedich-872	249	20	,	,	PUNCT
biomedich-872	249	21	fayaz	fayaz	PROPN
biomedich-872	249	22	,	,	PUNCT
biomedich-872	249	23	s.	s.	PROPN
biomedich-872	249	24	m.	m.	PROPN
biomedich-872	249	25	,	,	PUNCT
biomedich-872	249	26	sathyanarayana	sathyanarayana	PROPN
biomedich-872	249	27	,	,	PUNCT
biomedich-872	249	28	b.	b.	PROPN
biomedich-872	249	29	,	,	PUNCT
biomedich-872	249	30	&	&	CCONJ
biomedich-872	249	31	nayak	nayak	PROPN
biomedich-872	249	32	,	,	PUNCT
biomedich-872	249	33	y.	y.	PROPN
biomedich-872	249	34	(	(	PUNCT
biomedich-872	249	35	2025	2025	NUM
biomedich-872	249	36	)	)	PUNCT
biomedich-872	249	37	.	.	PUNCT
biomedich-872	250	1	network	network	NOUN
biomedich-872	250	2	pharmacology	pharmacology	NOUN
biomedich-872	250	3	-	-	PUNCT
biomedich-872	250	4	driven	drive	VERB
biomedich-872	250	5	therapeutic	therapeutic	ADJ
biomedich-872	250	6	interventions	intervention	NOUN
biomedich-872	250	7	for	for	ADP
biomedich-872	250	8	interstitial	interstitial	ADJ
biomedich-872	250	9	lung	lung	NOUN
biomedich-872	250	10	diseases	disease	NOUN
biomedich-872	250	11	using	use	VERB
biomedich-872	250	12	traditional	traditional	ADJ
biomedich-872	250	13	medicines	medicine	NOUN
biomedich-872	250	14	:	:	PUNCT
biomedich-872	250	15	a	a	DET
biomedich-872	250	16	narrative	narrative	NOUN
biomedich-872	250	17	review	review	NOUN
biomedich-872	250	18	.	.	PUNCT
biomedich-872	251	1	international	international	ADJ
biomedich-872	251	2	immunopharmacology	immunopharmacology	PROPN
biomedich-872	251	3	,	,	PUNCT
biomedich-872	251	4	147	147	NUM
biomedich-872	251	5	.	.	PUNCT
biomedich-872	252	1	https://doi.org/10.1016/j.intimp.2024.113979	https://doi.org/10.1016/j.intimp.2024.113979	PROPN
biomedich-872	252	2	wang	wang	PROPN
biomedich-872	252	3	,	,	PUNCT
biomedich-872	252	4	j.	j.	PROPN
biomedich-872	252	5	,	,	PUNCT
biomedich-872	252	6	hu	hu	PROPN
biomedich-872	252	7	,	,	PUNCT
biomedich-872	252	8	k.	k.	PROPN
biomedich-872	252	9	,	,	PUNCT
biomedich-872	252	10	cai	cai	PROPN
biomedich-872	252	11	,	,	PUNCT
biomedich-872	252	12	x.	x.	PROPN
biomedich-872	252	13	,	,	PUNCT
biomedich-872	252	14	yang	yang	PROPN
biomedich-872	252	15	,	,	PUNCT
biomedich-872	252	16	b.	b.	PROPN
biomedich-872	252	17	,	,	PUNCT
biomedich-872	252	18	he	he	PRON
biomedich-872	252	19	,	,	PUNCT
biomedich-872	252	20	q.	q.	PROPN
biomedich-872	252	21	,	,	PUNCT
biomedich-872	252	22	wang	wang	PROPN
biomedich-872	252	23	,	,	PUNCT
biomedich-872	252	24	j.	j.	PROPN
biomedich-872	252	25	,	,	PUNCT
biomedich-872	252	26	&	&	CCONJ
biomedich-872	252	27	weng	weng	PROPN
biomedich-872	252	28	,	,	PUNCT
biomedich-872	252	29	q.	q.	PROPN
biomedich-872	252	30	(	(	PUNCT
biomedich-872	252	31	2022	2022	NUM
biomedich-872	252	32	)	)	PUNCT
biomedich-872	252	33	.	.	PUNCT
biomedich-872	253	1	targeting	target	VERB
biomedich-872	253	2	pi3k	pi3k	PROPN
biomedich-872	253	3	/	/	SYM
biomedich-872	253	4	akt	akt	PROPN
biomedich-872	253	5	signaling	signal	VERB
biomedich-872	253	6	for	for	ADP
biomedich-872	253	7	treatment	treatment	NOUN
biomedich-872	253	8	of	of	ADP
biomedich-872	253	9	idiopathic	idiopathic	ADJ
biomedich-872	253	10	pulmonary	pulmonary	ADJ
biomedich-872	253	11	fibrosis	fibrosis	NOUN
biomedich-872	253	12	.	.	PUNCT
biomedich-872	254	1	acta	acta	PROPN
biomedich-872	254	2	pharmaceutica	pharmaceutica	PROPN
biomedich-872	254	3	sinica	sinica	PROPN
biomedich-872	254	4	b	b	PROPN
biomedich-872	254	5	,	,	PUNCT
biomedich-872	254	6	12(1	12(1	NUM
biomedich-872	254	7	)	)	PUNCT
biomedich-872	254	8	,	,	PUNCT
biomedich-872	254	9	18–32	18–32	NUM
biomedich-872	254	10	.	.	PUNCT
biomedich-872	255	1	https://doi.org/10.1016/j.apsb.2021.07.023	https://doi.org/10.1016/j.apsb.2021.07.023	NUM
biomedich-872	255	2	wiraswati	wiraswati	NOUN
biomedich-872	255	3	,	,	PUNCT
biomedich-872	255	4	h.	h.	PROPN
biomedich-872	255	5	l.	l.	PROPN
biomedich-872	255	6	,	,	PUNCT
biomedich-872	255	7	ekawardhani	ekawardhani	PROPN
biomedich-872	255	8	,	,	PUNCT
biomedich-872	255	9	s.	s.	PROPN
biomedich-872	255	10	,	,	PUNCT
biomedich-872	255	11	rohmawaty	rohmawaty	PROPN
biomedich-872	255	12	,	,	PUNCT
biomedich-872	255	13	e.	e.	PROPN
biomedich-872	255	14	,	,	PUNCT
biomedich-872	255	15	laelalugina	laelalugina	PROPN
biomedich-872	255	16	,	,	PUNCT
biomedich-872	255	17	a.	a.	NOUN
biomedich-872	255	18	,	,	PUNCT
biomedich-872	255	19	zuhrotun	zuhrotun	PROPN
biomedich-872	255	20	,	,	PUNCT
biomedich-872	255	21	a.	a.	NOUN
biomedich-872	255	22	,	,	PUNCT
biomedich-872	255	23	hendriani	hendriani	PROPN
biomedich-872	255	24	,	,	PUNCT
biomedich-872	255	25	r.	r.	PROPN
biomedich-872	255	26	,	,	PUNCT
biomedich-872	255	27	wardhana	wardhana	PROPN
biomedich-872	255	28	,	,	PUNCT
biomedich-872	255	29	y.	y.	PROPN
biomedich-872	255	30	w.	w.	PROPN
biomedich-872	255	31	,	,	PUNCT
biomedich-872	255	32	bestari	bestari	PROPN
biomedich-872	255	33	,	,	PUNCT
biomedich-872	255	34	m.	m.	PROPN
biomedich-872	255	35	b.	b.	PROPN
biomedich-872	255	36	,	,	PUNCT
biomedich-872	255	37	sahirdjan	sahirdjan	PROPN
biomedich-872	255	38	,	,	PUNCT
biomedich-872	255	39	e.	e.	PROPN
biomedich-872	255	40	h.	h.	PROPN
biomedich-872	255	41	,	,	PUNCT
biomedich-872	255	42	&	&	CCONJ
biomedich-872	255	43	dewi	dewi	PROPN
biomedich-872	255	44	,	,	PUNCT
biomedich-872	255	45	s.	s.	PROPN
biomedich-872	255	46	(	(	PUNCT
biomedich-872	255	47	2024	2024	NUM
biomedich-872	255	48	)	)	PUNCT
biomedich-872	255	49	.	.	PUNCT
biomedich-872	256	1	antioxidant	antioxidant	NOUN
biomedich-872	256	2	,	,	PUNCT
biomedich-872	256	3	antiinflammation	antiinflammation	NOUN
biomedich-872	256	4	,	,	PUNCT
biomedich-872	256	5	and	and	CCONJ
biomedich-872	256	6	antifibrotic	antifibrotic	ADJ
biomedich-872	256	7	activity	activity	NOUN
biomedich-872	256	8	of	of	ADP
biomedich-872	256	9	ciplukan	ciplukan	PROPN
biomedich-872	256	10	(	(	PUNCT
biomedich-872	256	11	physalis	physalis	NOUN
biomedich-872	256	12	angulata	angulata	ADJ
biomedich-872	256	13	l	l	NOUN
biomedich-872	256	14	)	)	PUNCT
biomedich-872	256	15	.	.	PUNCT
biomedich-872	257	1	extract	extract	NOUN
biomedich-872	257	2	.	.	PUNCT
biomedich-872	258	1	journal	journal	NOUN
biomedich-872	258	2	of	of	ADP
biomedich-872	258	3	inflammation	inflammation	PROPN
biomedich-872	258	4	research	research	NOUN
biomedich-872	258	5	,	,	PUNCT
biomedich-872	258	6	17	17	NUM
biomedich-872	258	7	,	,	PUNCT
biomedich-872	258	8	6297–6306	6297–6306	NOUN
biomedich-872	258	9	.	.	PUNCT
biomedich-872	259	1	https://doi.org/10.2147/jir.s470318	https://doi.org/10.2147/jir.s470318	CCONJ
biomedich-872	259	2	zaman	zaman	PROPN
biomedich-872	259	3	,	,	PUNCT
biomedich-872	259	4	t.	t.	PROPN
biomedich-872	259	5	,	,	PUNCT
biomedich-872	259	6	&	&	CCONJ
biomedich-872	259	7	lee	lee	PROPN
biomedich-872	259	8	,	,	PUNCT
biomedich-872	259	9	j.	j.	PROPN
biomedich-872	259	10	s.	s.	PROPN
biomedich-872	259	11	(	(	PUNCT
biomedich-872	259	12	2018	2018	NUM
biomedich-872	259	13	)	)	PUNCT
biomedich-872	259	14	.	.	PUNCT
biomedich-872	260	1	risk	risk	NOUN
biomedich-872	260	2	factors	factor	NOUN
biomedich-872	260	3	for	for	ADP
biomedich-872	260	4	the	the	DET
biomedich-872	260	5	development	development	NOUN
biomedich-872	260	6	of	of	ADP
biomedich-872	260	7	idiopathic	idiopathic	ADJ
biomedich-872	260	8	pulmonary	pulmonary	ADJ
biomedich-872	260	9	fibrosis	fibrosis	NOUN
biomedich-872	260	10	:	:	PUNCT
biomedich-872	260	11	a	a	DET
biomedich-872	260	12	review	review	NOUN
biomedich-872	260	13	.	.	PUNCT
biomedich-872	261	1	current	current	ADJ
biomedich-872	261	2	pulmonology	pulmonology	NOUN
biomedich-872	261	3	reports	report	NOUN
biomedich-872	261	4	,	,	PUNCT
biomedich-872	261	5	7(4	7(4	NUM
biomedich-872	261	6	)	)	PUNCT
biomedich-872	261	7	,	,	PUNCT
biomedich-872	261	8	118–125	118–125	NUM
biomedich-872	261	9	.	.	PUNCT
biomedich-872	262	1	https://doi.org/10.1007/s13665-018-0210-7	https://doi.org/10.1007/s13665-018-0210-7	PROPN
biomedich-872	262	2	zheng	zheng	PROPN
biomedich-872	262	3	,	,	PUNCT
biomedich-872	262	4	q.	q.	PROPN
biomedich-872	262	5	,	,	PUNCT
biomedich-872	262	6	cox	cox	PROPN
biomedich-872	262	7	,	,	PUNCT
biomedich-872	262	8	i.	i.	PROPN
biomedich-872	262	9	a.	a.	PROPN
biomedich-872	262	10	,	,	PUNCT
biomedich-872	262	11	campbell	campbell	PROPN
biomedich-872	262	12	,	,	PUNCT
biomedich-872	262	13	j.	j.	PROPN
biomedich-872	262	14	a.	a.	PROPN
biomedich-872	262	15	,	,	PUNCT
biomedich-872	262	16	xia	xia	PROPN
biomedich-872	262	17	,	,	PUNCT
biomedich-872	262	18	q.	q.	PROPN
biomedich-872	262	19	,	,	PUNCT
biomedich-872	262	20	otahal	otahal	ADJ
biomedich-872	262	21	,	,	PUNCT
biomedich-872	262	22	p.	p.	NOUN
biomedich-872	262	23	,	,	PUNCT
biomedich-872	262	24	de	de	PROPN
biomedich-872	262	25	graaff	graaff	PROPN
biomedich-872	262	26	,	,	PUNCT
biomedich-872	262	27	b.	b.	PROPN
biomedich-872	262	28	,	,	PUNCT
biomedich-872	262	29	corte	corte	PROPN
biomedich-872	262	30	,	,	PUNCT
biomedich-872	262	31	t.	t.	PROPN
biomedich-872	262	32	j.	j.	PROPN
biomedich-872	262	33	,	,	PUNCT
biomedich-872	262	34	teoh	teoh	PROPN
biomedich-872	262	35	,	,	PUNCT
biomedich-872	262	36	a.	a.	PROPN
biomedich-872	262	37	k.	k.	PROPN
biomedich-872	262	38	y.	y.	PROPN
biomedich-872	262	39	,	,	PUNCT
biomedich-872	262	40	walters	walters	PROPN
biomedich-872	262	41	,	,	PUNCT
biomedich-872	262	42	e.	e.	PROPN
biomedich-872	262	43	h.	h.	PROPN
biomedich-872	262	44	,	,	PUNCT
biomedich-872	262	45	&	&	CCONJ
biomedich-872	262	46	palmer	palmer	PROPN
biomedich-872	262	47	,	,	PUNCT
biomedich-872	262	48	a.	a.	PROPN
biomedich-872	262	49	j.	j.	PROPN
biomedich-872	262	50	(	(	PUNCT
biomedich-872	262	51	2022	2022	NUM
biomedich-872	262	52	)	)	PUNCT
biomedich-872	262	53	.	.	PUNCT
biomedich-872	263	1	mortality	mortality	NOUN
biomedich-872	263	2	and	and	CCONJ
biomedich-872	263	3	survival	survival	NOUN
biomedich-872	263	4	in	in	ADP
biomedich-872	263	5	idiopathic	idiopathic	ADJ
biomedich-872	263	6	pulmonary	pulmonary	ADJ
biomedich-872	263	7	fibrosis	fibrosis	NOUN
biomedich-872	263	8	:	:	PUNCT
biomedich-872	263	9	a	a	DET
biomedich-872	263	10	systematic	systematic	ADJ
biomedich-872	263	11	review	review	NOUN
biomedich-872	263	12	and	and	CCONJ
biomedich-872	263	13	meta	meta	ADJ
biomedich-872	263	14	-	-	PUNCT
biomedich-872	263	15	analysis	analysis	NOUN
biomedich-872	263	16	.	.	PUNCT
biomedich-872	264	1	erj	erj	PROPN
biomedich-872	264	2	open	open	PROPN
biomedich-872	264	3	research	research	PROPN
biomedich-872	264	4	,	,	PUNCT
biomedich-872	264	5	8(1	8(1	NOUN
biomedich-872	264	6	)	)	PUNCT
biomedich-872	264	7	.	.	PUNCT
biomedich-872	265	1	https://doi.org/10.1183/23120541.00591-2021	https://doi.org/10.1183/23120541.00591-2021	PUNCT
biomedich-872	266	1	zhou	zhou	PROPN
biomedich-872	266	2	,	,	PUNCT
biomedich-872	266	3	j.	j.	PROPN
biomedich-872	266	4	,	,	PUNCT
biomedich-872	266	5	hu	hu	PROPN
biomedich-872	266	6	,	,	PUNCT
biomedich-872	266	7	j.	j.	PROPN
biomedich-872	266	8	,	,	PUNCT
biomedich-872	266	9	liu	liu	PROPN
biomedich-872	266	10	,	,	PUNCT
biomedich-872	266	11	j.	j.	PROPN
biomedich-872	266	12	,	,	PUNCT
biomedich-872	266	13	&	&	CCONJ
biomedich-872	266	14	zhang	zhang	PROPN
biomedich-872	266	15	,	,	PUNCT
biomedich-872	266	16	w.	w.	PROPN
biomedich-872	266	17	(	(	PUNCT
biomedich-872	266	18	2024	2024	NUM
biomedich-872	266	19	)	)	PUNCT
biomedich-872	266	20	.	.	PUNCT
biomedich-872	267	1	elucidating	elucidate	VERB
biomedich-872	267	2	the	the	DET
biomedich-872	267	3	gastroprotective	gastroprotective	ADJ
biomedich-872	267	4	mechanisms	mechanism	NOUN
biomedich-872	267	5	of	of	ADP
biomedich-872	267	6	imperata	imperata	PROPN
biomedich-872	267	7	cylindrica	cylindrica	PROPN
biomedich-872	267	8	beauv.var	beauv.var	PROPN
biomedich-872	267	9	.	.	PROPN
biomedich-872	267	10	major	major	ADJ
biomedich-872	267	11	(	(	PUNCT
biomedich-872	267	12	nees	nee	NOUN
biomedich-872	267	13	)	)	PUNCT
biomedich-872	267	14	c.e.hubb	c.e.hubb	VERB
biomedich-872	267	15	through	through	ADP
biomedich-872	267	16	uhplc	uhplc	PROPN
biomedich-872	267	17	-	-	PUNCT
biomedich-872	267	18	ms	ms	PROPN
biomedich-872	267	19	/	/	SYM
biomedich-872	267	20	ms	ms	PROPN
biomedich-872	267	21	and	and	CCONJ
biomedich-872	267	22	systems	system	NOUN
biomedich-872	267	23	network	network	NOUN
biomedich-872	267	24	pharmacology	pharmacology	NOUN
biomedich-872	267	25	.	.	PUNCT
biomedich-872	268	1	scientific	scientific	ADJ
biomedich-872	268	2	reports	report	NOUN
biomedich-872	268	3	,	,	PUNCT
biomedich-872	268	4	14(1	14(1	NUM
biomedich-872	268	5	)	)	PUNCT
biomedich-872	268	6	.	.	PUNCT
biomedich-872	269	1	https://doi.org/10.1038/s41598-024-79483-z	https://doi.org/10.1038/s41598-024-79483-z	ADV