id	sid	tid	token	lemma	pos
biomedich-902	1	1	biology	biology	NOUN
biomedich-902	1	2	,	,	PUNCT
biomedich-902	1	3	medicine	medicine	NOUN
biomedich-902	1	4	,	,	PUNCT
biomedich-902	1	5	&	&	CCONJ
biomedich-902	1	6	natural	natural	ADJ
biomedich-902	1	7	product	product	NOUN
biomedich-902	1	8	chemistry	chemistry	NOUN
biomedich-902	1	9	issn	issn	VERB
biomedich-902	1	10	2089	2089	NUM
biomedich-902	1	11	-	-	SYM
biomedich-902	1	12	6514	6514	NUM
biomedich-902	1	13	(	(	PUNCT
biomedich-902	1	14	paper	paper	NOUN
biomedich-902	1	15	)	)	PUNCT
biomedich-902	1	16	volume	volume	NOUN
biomedich-902	1	17	14	14	NUM
biomedich-902	1	18	,	,	PUNCT
biomedich-902	1	19	number	number	NOUN
biomedich-902	1	20	2	2	NUM
biomedich-902	1	21	,	,	PUNCT
biomedich-902	1	22	october	october	PROPN
biomedich-902	1	23	2025	2025	NUM
biomedich-902	1	24	|	|	ADV
biomedich-902	1	25	pages	page	NOUN
biomedich-902	1	26	:	:	PUNCT
biomedich-902	1	27	1105	1105	NUM
biomedich-902	1	28	-	-	SYM
biomedich-902	1	29	1110	1110	NUM
biomedich-902	1	30	|	|	ADV
biomedich-902	1	31	doi	doi	NOUN
biomedich-902	1	32	:	:	PUNCT
biomedich-902	1	33	10.14421	10.14421	NUM
biomedich-902	1	34	/	/	SYM
biomedich-902	1	35	biomedich.2025.142.1105	biomedich.2025.142.1105	PROPN
biomedich-902	1	36	-	-	PUNCT
biomedich-902	1	37	1110	1110	NUM
biomedich-902	1	38	issn	issn	PROPN
biomedich-902	1	39	2540	2540	NUM
biomedich-902	1	40	-	-	SYM
biomedich-902	1	41	9328	9328	NUM
biomedich-902	1	42	(	(	PUNCT
biomedich-902	1	43	online	online	ADJ
biomedich-902	1	44	)	)	PUNCT
biomedich-902	1	45	computational	computational	ADJ
biomedich-902	1	46	insights	insight	NOUN
biomedich-902	1	47	into	into	ADP
biomedich-902	1	48	the	the	DET
biomedich-902	1	49	comparative	comparative	ADJ
biomedich-902	1	50	analysis	analysis	NOUN
biomedich-902	1	51	of	of	ADP
biomedich-902	1	52	insulinlike	insulinlike	NOUN
biomedich-902	1	53	compounds	compound	NOUN
biomedich-902	1	54	in	in	ADP
biomedich-902	1	55	bitter	bitter	ADJ
biomedich-902	1	56	melon	melon	NOUN
biomedich-902	1	57	:	:	PUNCT
biomedich-902	1	58	targeting	target	VERB
biomedich-902	1	59	gsk-3	gsk-3	DET
biomedich-902	1	60	protein	protein	NOUN
biomedich-902	1	61	and	and	CCONJ
biomedich-902	1	62	insulin	insulin	NOUN
biomedich-902	1	63	receptor	receptor	NOUN
biomedich-902	1	64	fernando	fernando	PROPN
biomedich-902	1	65	nalini	nalini	PROPN
biomedich-902	1	66	prasangika	prasangika	PROPN
biomedich-902	1	67	department	department	PROPN
biomedich-902	1	68	of	of	ADP
biomedich-902	1	69	chemistry	chemistry	NOUN
biomedich-902	1	70	,	,	PUNCT
biomedich-902	1	71	university	university	NOUN
biomedich-902	1	72	of	of	ADP
biomedich-902	1	73	kelaniya	kelaniya	PROPN
biomedich-902	1	74	,	,	PUNCT
biomedich-902	1	75	kelaniya	kelaniya	PROPN
biomedich-902	1	76	11600	11600	NUM
biomedich-902	1	77	,	,	PUNCT
biomedich-902	1	78	sri	sri	PROPN
biomedich-902	1	79	lanka	lanka	PROPN
biomedich-902	1	80	.	.	PUNCT
biomedich-902	2	1	fernando	fernando	PROPN
biomedich-902	2	2	nalini	nalini	PROPN
biomedich-902	2	3	prasangika	prasangika	PROPN
biomedich-902	2	4	,	,	PUNCT
biomedich-902	2	5	university	university	NOUN
biomedich-902	2	6	of	of	ADP
biomedich-902	2	7	kelaniya	kelaniya	PROPN
biomedich-902	2	8	,	,	PUNCT
biomedich-902	2	9	tel	tel	PROPN
biomedich-902	2	10	.	.	PUNCT
biomedich-902	3	1	+94713716698	+94713716698	ADJ
biomedich-902	3	2	,	,	PUNCT
biomedich-902	3	3	sri	sri	PROPN
biomedich-902	3	4	lanka	lanka	PROPN
biomedich-902	3	5	.	.	PUNCT
biomedich-902	4	1	corresponding	correspond	VERB
biomedich-902	4	2	author	author	NOUN
biomedich-902	4	3	naliniprasangika@gmail.com	naliniprasangika@gmail.com	X
biomedich-902	5	1	manuscript	manuscript	NOUN
biomedich-902	5	2	received	receive	VERB
biomedich-902	5	3	:	:	PUNCT
biomedich-902	5	4	06	06	NUM
biomedich-902	5	5	august	august	PROPN
biomedich-902	5	6	,	,	PUNCT
biomedich-902	5	7	2025	2025	NUM
biomedich-902	5	8	.	.	PUNCT
biomedich-902	6	1	revision	revision	NOUN
biomedich-902	6	2	accepted	accept	VERB
biomedich-902	6	3	:	:	PUNCT
biomedich-902	6	4	21	21	NUM
biomedich-902	6	5	november	november	PROPN
biomedich-902	6	6	,	,	PUNCT
biomedich-902	6	7	2025	2025	NUM
biomedich-902	6	8	.	.	PUNCT
biomedich-902	7	1	published	publish	VERB
biomedich-902	7	2	:	:	PUNCT
biomedich-902	7	3	27	27	NUM
biomedich-902	7	4	november	november	PROPN
biomedich-902	7	5	,	,	PUNCT
biomedich-902	7	6	2025	2025	NUM
biomedich-902	7	7	.	.	PUNCT
biomedich-902	8	1	abstract	abstract	ADJ
biomedich-902	8	2	diabetes	diabetes	NOUN
biomedich-902	8	3	,	,	PUNCT
biomedich-902	8	4	a	a	DET
biomedich-902	8	5	rapidly	rapidly	ADV
biomedich-902	8	6	escalating	escalate	VERB
biomedich-902	8	7	global	global	ADJ
biomedich-902	8	8	health	health	NOUN
biomedich-902	8	9	challenge	challenge	NOUN
biomedich-902	8	10	,	,	PUNCT
biomedich-902	8	11	is	be	AUX
biomedich-902	8	12	defined	define	VERB
biomedich-902	8	13	by	by	ADP
biomedich-902	8	14	chronic	chronic	ADJ
biomedich-902	8	15	hyperglycemia	hyperglycemia	NOUN
biomedich-902	8	16	resulting	result	VERB
biomedich-902	8	17	from	from	ADP
biomedich-902	8	18	impaired	impaired	ADJ
biomedich-902	8	19	insulin	insulin	NOUN
biomedich-902	8	20	secretion	secretion	NOUN
biomedich-902	8	21	,	,	PUNCT
biomedich-902	8	22	impaired	impaired	ADJ
biomedich-902	8	23	insulin	insulin	NOUN
biomedich-902	8	24	action	action	NOUN
biomedich-902	8	25	,	,	PUNCT
biomedich-902	8	26	or	or	CCONJ
biomedich-902	8	27	both	both	PRON
biomedich-902	8	28	.	.	PUNCT
biomedich-902	9	1	current	current	ADJ
biomedich-902	9	2	treatment	treatment	NOUN
biomedich-902	9	3	options	option	NOUN
biomedich-902	9	4	often	often	ADV
biomedich-902	9	5	fall	fall	VERB
biomedich-902	9	6	short	short	ADJ
biomedich-902	9	7	due	due	ADP
biomedich-902	9	8	to	to	ADP
biomedich-902	9	9	side	side	ADJ
biomedich-902	9	10	effects	effect	NOUN
biomedich-902	9	11	and	and	CCONJ
biomedich-902	9	12	limited	limited	ADJ
biomedich-902	9	13	efficacy	efficacy	NOUN
biomedich-902	9	14	in	in	ADP
biomedich-902	9	15	addressing	address	VERB
biomedich-902	9	16	long	long	ADJ
biomedich-902	9	17	-	-	PUNCT
biomedich-902	9	18	term	term	NOUN
biomedich-902	9	19	complications	complication	NOUN
biomedich-902	9	20	,	,	PUNCT
biomedich-902	9	21	underscoring	underscore	VERB
biomedich-902	9	22	the	the	DET
biomedich-902	9	23	urgent	urgent	ADJ
biomedich-902	9	24	need	need	NOUN
biomedich-902	9	25	for	for	ADP
biomedich-902	9	26	safer	safe	ADJ
biomedich-902	9	27	,	,	PUNCT
biomedich-902	9	28	more	more	ADV
biomedich-902	9	29	effective	effective	ADJ
biomedich-902	9	30	alternatives	alternative	NOUN
biomedich-902	9	31	.	.	PUNCT
biomedich-902	10	1	this	this	DET
biomedich-902	10	2	study	study	NOUN
biomedich-902	10	3	delves	delve	VERB
biomedich-902	10	4	into	into	ADP
biomedich-902	10	5	the	the	DET
biomedich-902	10	6	potential	potential	NOUN
biomedich-902	10	7	of	of	ADP
biomedich-902	10	8	insulin	insulin	NOUN
biomedich-902	10	9	-	-	PUNCT
biomedich-902	10	10	like	like	ADJ
biomedich-902	10	11	compounds	compound	NOUN
biomedich-902	10	12	derived	derive	VERB
biomedich-902	10	13	from	from	ADP
biomedich-902	10	14	bitter	bitter	ADJ
biomedich-902	10	15	melon	melon	NOUN
biomedich-902	10	16	(	(	PUNCT
biomedich-902	10	17	momordica	momordica	PROPN
biomedich-902	10	18	charantia	charantia	PROPN
biomedich-902	10	19	)	)	PUNCT
biomedich-902	10	20	to	to	PART
biomedich-902	10	21	combat	combat	VERB
biomedich-902	10	22	diabetes	diabetes	NOUN
biomedich-902	10	23	by	by	ADP
biomedich-902	10	24	targeting	target	VERB
biomedich-902	10	25	two	two	NUM
biomedich-902	10	26	pivotal	pivotal	ADJ
biomedich-902	10	27	proteins	protein	NOUN
biomedich-902	10	28	:	:	PUNCT
biomedich-902	10	29	glycogen	glycogen	NOUN
biomedich-902	10	30	synthase	synthase	NOUN
biomedich-902	10	31	kinase-3	kinase-3	PROPN
biomedich-902	10	32	(	(	PUNCT
biomedich-902	10	33	gsk-3	gsk-3	NOUN
biomedich-902	10	34	)	)	PUNCT
biomedich-902	10	35	and	and	CCONJ
biomedich-902	10	36	insulin	insulin	NOUN
biomedich-902	10	37	receptors	receptor	NOUN
biomedich-902	10	38	.	.	PUNCT
biomedich-902	11	1	these	these	DET
biomedich-902	11	2	proteins	protein	NOUN
biomedich-902	11	3	are	be	AUX
biomedich-902	11	4	crucial	crucial	ADJ
biomedich-902	11	5	for	for	ADP
biomedich-902	11	6	glucose	glucose	NOUN
biomedich-902	11	7	regulation	regulation	NOUN
biomedich-902	11	8	and	and	CCONJ
biomedich-902	11	9	insulin	insulin	NOUN
biomedich-902	11	10	signaling	signal	VERB
biomedich-902	11	11	,	,	PUNCT
biomedich-902	11	12	making	make	VERB
biomedich-902	11	13	them	they	PRON
biomedich-902	11	14	key	key	ADJ
biomedich-902	11	15	targets	target	NOUN
biomedich-902	11	16	for	for	ADP
biomedich-902	11	17	blood	blood	NOUN
biomedich-902	11	18	sugar	sugar	NOUN
biomedich-902	11	19	control.through	control.through	ADP
biomedich-902	11	20	computational	computational	ADJ
biomedich-902	11	21	molecular	molecular	ADJ
biomedich-902	11	22	docking	docking	NOUN
biomedich-902	11	23	,	,	PUNCT
biomedich-902	11	24	we	we	PRON
biomedich-902	11	25	evaluated	evaluate	VERB
biomedich-902	11	26	the	the	DET
biomedich-902	11	27	binding	bind	VERB
biomedich-902	11	28	affinities	affinity	NOUN
biomedich-902	11	29	and	and	CCONJ
biomedich-902	11	30	inhibition	inhibition	VERB
biomedich-902	11	31	potentials	potential	NOUN
biomedich-902	11	32	of	of	ADP
biomedich-902	11	33	key	key	ADJ
biomedich-902	11	34	bitter	bitter	ADJ
biomedich-902	11	35	melon	melon	NOUN
biomedich-902	11	36	compounds	compound	NOUN
biomedich-902	11	37	,	,	PUNCT
biomedich-902	11	38	including	include	VERB
biomedich-902	11	39	charantin	charantin	NOUN
biomedich-902	11	40	and	and	CCONJ
biomedich-902	11	41	vicine	vicine	ADJ
biomedich-902	11	42	.	.	PUNCT
biomedich-902	12	1	molecular	molecular	ADJ
biomedich-902	12	2	structures	structure	NOUN
biomedich-902	12	3	were	be	AUX
biomedich-902	12	4	sourced	source	VERB
biomedich-902	12	5	from	from	ADP
biomedich-902	12	6	the	the	DET
biomedich-902	12	7	pubchem	pubchem	NOUN
biomedich-902	12	8	database	database	NOUN
biomedich-902	12	9	and	and	CCONJ
biomedich-902	12	10	optimized	optimize	VERB
biomedich-902	12	11	using	use	VERB
biomedich-902	12	12	density	density	NOUN
biomedich-902	12	13	functional	functional	ADJ
biomedich-902	12	14	theory	theory	NOUN
biomedich-902	12	15	(	(	PUNCT
biomedich-902	12	16	b3lyp	b3lyp	X
biomedich-902	12	17	functional	functional	ADJ
biomedich-902	12	18	,	,	PUNCT
biomedich-902	12	19	6	6	NUM
biomedich-902	12	20	-	-	SYM
biomedich-902	12	21	311g++	311g++	NUM
biomedich-902	12	22	(	(	PUNCT
biomedich-902	12	23	d	d	NOUN
biomedich-902	12	24	,	,	PUNCT
biomedich-902	12	25	p	p	NOUN
biomedich-902	12	26	)	)	PUNCT
biomedich-902	12	27	basis	basis	NOUN
biomedich-902	12	28	set	set	NOUN
biomedich-902	12	29	)	)	PUNCT
biomedich-902	12	30	with	with	ADP
biomedich-902	12	31	gaussian-09	gaussian-09	PROPN
biomedich-902	12	32	software	software	NOUN
biomedich-902	12	33	.	.	PUNCT
biomedich-902	13	1	structural	structural	ADJ
biomedich-902	13	2	data	datum	NOUN
biomedich-902	13	3	for	for	ADP
biomedich-902	13	4	gsk-3	gsk-3	PUNCT
biomedich-902	13	5	(	(	PUNCT
biomedich-902	13	6	pdb	pdb	PROPN
biomedich-902	13	7	i	i	PROPN
biomedich-902	13	8	d	d	PROPN
biomedich-902	13	9	:	:	PUNCT
biomedich-902	13	10	1q5k	1q5k	NUM
biomedich-902	13	11	)	)	PUNCT
biomedich-902	13	12	and	and	CCONJ
biomedich-902	13	13	insulin	insulin	NOUN
biomedich-902	13	14	receptors	receptor	NOUN
biomedich-902	13	15	(	(	PUNCT
biomedich-902	13	16	pdb	pdb	PROPN
biomedich-902	13	17	i	i	PROPN
biomedich-902	13	18	d	d	PROPN
biomedich-902	13	19	:	:	PUNCT
biomedich-902	13	20	1ir3	1ir3	NUM
biomedich-902	13	21	)	)	PUNCT
biomedich-902	13	22	were	be	AUX
biomedich-902	13	23	retrieved	retrieve	VERB
biomedich-902	13	24	from	from	ADP
biomedich-902	13	25	the	the	DET
biomedich-902	13	26	protein	protein	NOUN
biomedich-902	13	27	data	datum	NOUN
biomedich-902	13	28	bank	bank	NOUN
biomedich-902	13	29	,	,	PUNCT
biomedich-902	13	30	and	and	CCONJ
biomedich-902	13	31	docking	dock	VERB
biomedich-902	13	32	studies	study	NOUN
biomedich-902	13	33	were	be	AUX
biomedich-902	13	34	conducted	conduct	VERB
biomedich-902	13	35	using	use	VERB
biomedich-902	13	36	the	the	DET
biomedich-902	13	37	lamarckian	lamarckian	ADJ
biomedich-902	13	38	genetic	genetic	ADJ
biomedich-902	13	39	algorithm	algorithm	NOUN
biomedich-902	13	40	in	in	ADP
biomedich-902	13	41	autodock	autodock	NOUN
biomedich-902	13	42	4.2	4.2	NUM
biomedich-902	13	43	.	.	PUNCT
biomedich-902	14	1	protein	protein	NOUN
biomedich-902	14	2	-	-	PUNCT
biomedich-902	14	3	ligand	ligand	NOUN
biomedich-902	14	4	interactions	interaction	NOUN
biomedich-902	14	5	,	,	PUNCT
biomedich-902	14	6	bond	bond	NOUN
biomedich-902	14	7	lengths	length	NOUN
biomedich-902	14	8	,	,	PUNCT
biomedich-902	14	9	and	and	CCONJ
biomedich-902	14	10	amino	amino	NOUN
biomedich-902	14	11	acid	acid	NOUN
biomedich-902	14	12	residues	residue	NOUN
biomedich-902	14	13	in	in	ADP
biomedich-902	14	14	binding	bind	VERB
biomedich-902	14	15	pockets	pocket	NOUN
biomedich-902	14	16	were	be	AUX
biomedich-902	14	17	analyzed	analyze	VERB
biomedich-902	14	18	with	with	ADP
biomedich-902	14	19	discovery	discovery	NOUN
biomedich-902	14	20	studio	studio	NOUN
biomedich-902	14	21	,	,	PUNCT
biomedich-902	14	22	while	while	SCONJ
biomedich-902	14	23	admet	admet	PROPN
biomedich-902	14	24	profiles	profile	NOUN
biomedich-902	14	25	and	and	CCONJ
biomedich-902	14	26	toxicity	toxicity	NOUN
biomedich-902	14	27	levels	level	NOUN
biomedich-902	14	28	were	be	AUX
biomedich-902	14	29	predicted	predict	VERB
biomedich-902	14	30	using	use	VERB
biomedich-902	14	31	pkcsm	pkcsm	NOUN
biomedich-902	14	32	and	and	CCONJ
biomedich-902	14	33	protoxii.charantin	protoxii.charantin	CCONJ
biomedich-902	14	34	demonstrated	demonstrate	VERB
biomedich-902	14	35	the	the	DET
biomedich-902	14	36	highest	high	ADJ
biomedich-902	14	37	binding	bind	VERB
biomedich-902	14	38	affinity	affinity	NOUN
biomedich-902	14	39	and	and	CCONJ
biomedich-902	14	40	inhibition	inhibition	VERB
biomedich-902	14	41	potential	potential	NOUN
biomedich-902	14	42	against	against	ADP
biomedich-902	14	43	both	both	DET
biomedich-902	14	44	gsk-3	gsk-3	NOUN
biomedich-902	14	45	and	and	CCONJ
biomedich-902	14	46	insulin	insulin	NOUN
biomedich-902	14	47	receptors	receptor	NOUN
biomedich-902	14	48	.	.	PUNCT
biomedich-902	15	1	toxicity	toxicity	NOUN
biomedich-902	15	2	analysis	analysis	NOUN
biomedich-902	15	3	revealed	reveal	VERB
biomedich-902	15	4	that	that	SCONJ
biomedich-902	15	5	charantin	charantin	NOUN
biomedich-902	15	6	,	,	PUNCT
biomedich-902	15	7	classified	classify	VERB
biomedich-902	15	8	under	under	ADP
biomedich-902	15	9	toxicity	toxicity	NOUN
biomedich-902	15	10	class	class	NOUN
biomedich-902	15	11	6	6	NUM
biomedich-902	15	12	,	,	PUNCT
biomedich-902	15	13	is	be	AUX
biomedich-902	15	14	safer	safe	ADJ
biomedich-902	15	15	than	than	ADP
biomedich-902	15	16	vicine	vicine	ADJ
biomedich-902	15	17	(	(	PUNCT
biomedich-902	15	18	class	class	NOUN
biomedich-902	15	19	4	4	NUM
biomedich-902	15	20	)	)	PUNCT
biomedich-902	15	21	,	,	PUNCT
biomedich-902	15	22	with	with	ADP
biomedich-902	15	23	a	a	DET
biomedich-902	15	24	higher	high	ADJ
biomedich-902	15	25	ld50	ld50	PROPN
biomedich-902	15	26	value	value	NOUN
biomedich-902	15	27	indicating	indicate	VERB
biomedich-902	15	28	lower	low	ADJ
biomedich-902	15	29	toxicity	toxicity	NOUN
biomedich-902	15	30	.	.	PUNCT
biomedich-902	16	1	these	these	DET
biomedich-902	16	2	findings	finding	NOUN
biomedich-902	16	3	position	position	NOUN
biomedich-902	16	4	charantin	charantin	NOUN
biomedich-902	16	5	as	as	ADP
biomedich-902	16	6	a	a	DET
biomedich-902	16	7	promising	promising	ADJ
biomedich-902	16	8	multi	multi	ADJ
biomedich-902	16	9	-	-	ADJ
biomedich-902	16	10	target	target	ADJ
biomedich-902	16	11	anti	anti	ADJ
biomedich-902	16	12	-	-	ADJ
biomedich-902	16	13	diabetic	diabetic	ADJ
biomedich-902	16	14	agent	agent	NOUN
biomedich-902	16	15	with	with	ADP
biomedich-902	16	16	significant	significant	ADJ
biomedich-902	16	17	efficacy	efficacy	NOUN
biomedich-902	16	18	and	and	CCONJ
biomedich-902	16	19	minimal	minimal	ADJ
biomedich-902	16	20	side	side	NOUN
biomedich-902	16	21	effects	effect	NOUN
biomedich-902	16	22	.	.	PUNCT
biomedich-902	17	1	this	this	DET
biomedich-902	17	2	research	research	NOUN
biomedich-902	17	3	paves	pave	VERB
biomedich-902	17	4	the	the	DET
biomedich-902	17	5	way	way	NOUN
biomedich-902	17	6	for	for	ADP
biomedich-902	17	7	developing	develop	VERB
biomedich-902	17	8	novel	novel	NOUN
biomedich-902	17	9	,	,	PUNCT
biomedich-902	17	10	safer	safe	ADJ
biomedich-902	17	11	anti	anti	ADJ
biomedich-902	17	12	-	-	ADJ
biomedich-902	17	13	diabetic	diabetic	ADJ
biomedich-902	17	14	medications	medication	NOUN
biomedich-902	17	15	derived	derive	VERB
biomedich-902	17	16	from	from	ADP
biomedich-902	17	17	natural	natural	ADJ
biomedich-902	17	18	sources	source	NOUN
biomedich-902	17	19	,	,	PUNCT
biomedich-902	17	20	offering	offer	VERB
biomedich-902	17	21	a	a	DET
biomedich-902	17	22	beacon	beacon	NOUN
biomedich-902	17	23	of	of	ADP
biomedich-902	17	24	hope	hope	NOUN
biomedich-902	17	25	in	in	ADP
biomedich-902	17	26	the	the	DET
biomedich-902	17	27	fight	fight	NOUN
biomedich-902	17	28	against	against	ADP
biomedich-902	17	29	diabetes	diabetes	NOUN
biomedich-902	17	30	.	.	PUNCT
biomedich-902	18	1	keywords	keyword	NOUN
biomedich-902	18	2	:	:	PUNCT
biomedich-902	18	3	gsk-3	gsk-3	NOUN
biomedich-902	18	4	protein	protein	NOUN
biomedich-902	18	5	;	;	PUNCT
biomedich-902	18	6	insulin	insulin	NOUN
biomedich-902	18	7	receptor	receptor	NOUN
biomedich-902	18	8	;	;	PUNCT
biomedich-902	18	9	molecular	molecular	ADJ
biomedich-902	18	10	docking	docking	NOUN
biomedich-902	18	11	;	;	PUNCT
biomedich-902	18	12	optimization	optimization	NOUN
biomedich-902	18	13	;	;	PUNCT
biomedich-902	18	14	toxicity	toxicity	NOUN
biomedich-902	18	15	.	.	PUNCT
biomedich-902	19	1	abbreviations	abbreviation	NOUN
biomedich-902	19	2	:	:	PUNCT
biomedich-902	19	3	gsk-3	gsk-3	X
biomedich-902	19	4	glycogen	glycogen	NOUN
biomedich-902	19	5	synthase	synthase	NOUN
biomedich-902	19	6	kinase-3	kinase-3	PROPN
biomedich-902	19	7	,	,	PUNCT
biomedich-902	19	8	irinsulin	irinsulin	NOUN
biomedich-902	19	9	receptors	receptor	NOUN
biomedich-902	19	10	introduction	introduction	NOUN
biomedich-902	19	11	the	the	DET
biomedich-902	19	12	medicinal	medicinal	ADJ
biomedich-902	19	13	plant	plant	NOUN
biomedich-902	19	14	bitter	bitter	ADJ
biomedich-902	19	15	melon	melon	NOUN
biomedich-902	19	16	(	(	PUNCT
biomedich-902	19	17	momordica	momordica	PROPN
biomedich-902	19	18	charantia	charantia	PROPN
biomedich-902	19	19	)	)	PUNCT
biomedich-902	19	20	is	be	AUX
biomedich-902	19	21	well	well	ADV
biomedich-902	19	22	known	known	ADJ
biomedich-902	19	23	for	for	ADP
biomedich-902	19	24	its	its	PRON
biomedich-902	19	25	possible	possible	ADJ
biomedich-902	19	26	anti	anti	ADJ
biomedich-902	19	27	-	-	ADJ
biomedich-902	19	28	diabetic	diabetic	ADJ
biomedich-902	19	29	properties	property	NOUN
biomedich-902	19	30	.	.	PUNCT
biomedich-902	20	1	according	accord	VERB
biomedich-902	20	2	to	to	ADP
biomedich-902	20	3	research	research	NOUN
biomedich-902	20	4	,	,	PUNCT
biomedich-902	20	5	the	the	DET
biomedich-902	20	6	hypoglycemic	hypoglycemic	ADJ
biomedich-902	20	7	qualities	quality	NOUN
biomedich-902	20	8	of	of	ADP
biomedich-902	20	9	bitter	bitter	ADJ
biomedich-902	20	10	melon	melon	NOUN
biomedich-902	20	11	are	be	AUX
biomedich-902	20	12	attributed	attribute	VERB
biomedich-902	20	13	to	to	ADP
biomedich-902	20	14	a	a	DET
biomedich-902	20	15	number	number	NOUN
biomedich-902	20	16	of	of	ADP
biomedich-902	20	17	bioactive	bioactive	ADJ
biomedich-902	20	18	substances	substance	NOUN
biomedich-902	20	19	,	,	PUNCT
biomedich-902	20	20	mainly	mainly	ADV
biomedich-902	20	21	charantin	charantin	NOUN
biomedich-902	20	22	,	,	PUNCT
biomedich-902	20	23	vicine	vicine	ADJ
biomedich-902	20	24	,	,	PUNCT
biomedich-902	20	25	polypeptide	polypeptide	ADJ
biomedich-902	20	26	-	-	PUNCT
biomedich-902	20	27	p	p	NOUN
biomedich-902	20	28	,	,	PUNCT
biomedich-902	20	29	and	and	CCONJ
biomedich-902	20	30	certain	certain	ADJ
biomedich-902	20	31	lectins	lectin	NOUN
biomedich-902	20	32	.	.	PUNCT
biomedich-902	21	1	due	due	ADJ
biomedich-902	21	2	in	in	ADP
biomedich-902	21	3	large	large	ADJ
biomedich-902	21	4	part	part	NOUN
biomedich-902	21	5	to	to	PART
biomedich-902	21	6	bioactive	bioactive	VERB
biomedich-902	21	7	substances	substance	NOUN
biomedich-902	21	8	like	like	ADP
biomedich-902	21	9	charantin	charantin	NOUN
biomedich-902	21	10	and	and	CCONJ
biomedich-902	21	11	vicine	vicine	NOUN
biomedich-902	21	12	that	that	PRON
biomedich-902	21	13	imitate	imitate	VERB
biomedich-902	21	14	the	the	DET
biomedich-902	21	15	action	action	NOUN
biomedich-902	21	16	of	of	ADP
biomedich-902	21	17	insulin	insulin	NOUN
biomedich-902	21	18	and	and	CCONJ
biomedich-902	21	19	increase	increase	VERB
biomedich-902	21	20	insulin	insulin	NOUN
biomedich-902	21	21	receptor	receptor	NOUN
biomedich-902	21	22	activation	activation	NOUN
biomedich-902	21	23	,	,	PUNCT
biomedich-902	21	24	bitter	bitter	ADJ
biomedich-902	21	25	melon	melon	NOUN
biomedich-902	21	26	(	(	PUNCT
biomedich-902	21	27	momordica	momordica	PROPN
biomedich-902	21	28	charantia	charantia	PROPN
biomedich-902	21	29	)	)	PUNCT
biomedich-902	21	30	is	be	AUX
biomedich-902	21	31	a	a	DET
biomedich-902	21	32	medicinal	medicinal	ADJ
biomedich-902	21	33	plant	plant	NOUN
biomedich-902	21	34	with	with	ADP
biomedich-902	21	35	noteworthy	noteworthy	ADJ
biomedich-902	21	36	anti	anti	ADJ
biomedich-902	21	37	-	-	ADJ
biomedich-902	21	38	diabetic	diabetic	ADJ
biomedich-902	21	39	qualities	quality	NOUN
biomedich-902	21	40	.	.	PUNCT
biomedich-902	22	1	bitter	bitter	ADJ
biomedich-902	22	2	melon	melon	NOUN
biomedich-902	22	3	is	be	AUX
biomedich-902	22	4	a	a	DET
biomedich-902	22	5	viable	viable	ADJ
biomedich-902	22	6	natural	natural	ADJ
biomedich-902	22	7	option	option	NOUN
biomedich-902	22	8	for	for	ADP
biomedich-902	22	9	managing	manage	VERB
biomedich-902	22	10	diabetes	diabete	NOUN
biomedich-902	22	11	because	because	SCONJ
biomedich-902	22	12	of	of	ADP
biomedich-902	22	13	these	these	DET
biomedich-902	22	14	chemicals	chemical	NOUN
biomedich-902	22	15	,	,	PUNCT
biomedich-902	22	16	which	which	PRON
biomedich-902	22	17	helps	help	VERB
biomedich-902	22	18	control	control	VERB
biomedich-902	22	19	glucose	glucose	NOUN
biomedich-902	22	20	metabolism	metabolism	NOUN
biomedich-902	22	21	by	by	ADP
biomedich-902	22	22	boosting	boost	VERB
biomedich-902	22	23	glucose	glucose	NOUN
biomedich-902	22	24	uptake	uptake	NOUN
biomedich-902	22	25	,	,	PUNCT
biomedich-902	22	26	glycogen	glycogen	NOUN
biomedich-902	22	27	formation	formation	NOUN
biomedich-902	22	28	,	,	PUNCT
biomedich-902	22	29	and	and	CCONJ
biomedich-902	22	30	enhancing	enhance	VERB
biomedich-902	22	31	insulin	insulin	NOUN
biomedich-902	22	32	signaling	signaling	NOUN
biomedich-902	22	33	.	.	PUNCT
biomedich-902	23	1	even	even	ADV
biomedich-902	23	2	though	though	SCONJ
biomedich-902	23	3	a	a	DET
biomedich-902	23	4	large	large	ADJ
biomedich-902	23	5	number	number	NOUN
biomedich-902	23	6	of	of	ADP
biomedich-902	23	7	studies	study	NOUN
biomedich-902	23	8	have	have	AUX
biomedich-902	23	9	demonstrated	demonstrate	VERB
biomedich-902	23	10	its	its	PRON
biomedich-902	23	11	positive	positive	ADJ
biomedich-902	23	12	effects	effect	NOUN
biomedich-902	23	13	,	,	PUNCT
biomedich-902	23	14	more	more	ADJ
biomedich-902	23	15	investigation	investigation	NOUN
biomedich-902	23	16	is	be	AUX
biomedich-902	23	17	required	require	VERB
biomedich-902	23	18	to	to	PART
biomedich-902	23	19	ensure	ensure	VERB
biomedich-902	23	20	safe	safe	ADJ
biomedich-902	23	21	and	and	CCONJ
biomedich-902	23	22	effective	effective	ADJ
biomedich-902	23	23	use	use	NOUN
biomedich-902	23	24	in	in	ADP
biomedich-902	23	25	conjunction	conjunction	NOUN
biomedich-902	23	26	with	with	ADP
biomedich-902	23	27	traditional	traditional	ADJ
biomedich-902	23	28	therapies.(joseph	therapies.(joseph	NOUN
biomedich-902	23	29	&	&	CCONJ
biomedich-902	23	30	jini	jini	PROPN
biomedich-902	23	31	,	,	PUNCT
biomedich-902	23	32	2013),(liu	2013),(liu	NUM
biomedich-902	23	33	et	et	NOUN
biomedich-902	23	34	al	al	PROPN
biomedich-902	23	35	.	.	PROPN
biomedich-902	23	36	,	,	PUNCT
biomedich-902	23	37	2021	2021	NUM
biomedich-902	23	38	)	)	PUNCT
biomedich-902	23	39	charantin	charantin	PROPN
biomedich-902	23	40	charantin	charantin	X
biomedich-902	23	41	(	(	PUNCT
biomedich-902	23	42	as	as	SCONJ
biomedich-902	23	43	shown	show	VERB
biomedich-902	23	44	in	in	ADP
biomedich-902	23	45	figure	figure	NOUN
biomedich-902	23	46	1	1	NUM
biomedich-902	23	47	)	)	PUNCT
biomedich-902	23	48	is	be	AUX
biomedich-902	23	49	a	a	DET
biomedich-902	23	50	triterpenoid	triterpenoid	NOUN
biomedich-902	23	51	combination	combination	NOUN
biomedich-902	23	52	of	of	ADP
biomedich-902	23	53	the	the	DET
biomedich-902	23	54	cucurbitane	cucurbitane	ADJ
biomedich-902	23	55	type	type	NOUN
biomedich-902	23	56	that	that	PRON
biomedich-902	23	57	is	be	AUX
biomedich-902	23	58	mostly	mostly	ADV
biomedich-902	23	59	made	make	VERB
biomedich-902	23	60	up	up	ADP
biomedich-902	23	61	of	of	ADP
biomedich-902	23	62	stigmasteryl	stigmasteryl	PROPN
biomedich-902	23	63	glucoside	glucoside	NOUN
biomedich-902	23	64	and	and	CCONJ
biomedich-902	23	65	sitosteryl	sitosteryl	NOUN
biomedich-902	23	66	glucoside	glucoside	NOUN
biomedich-902	23	67	.	.	PUNCT
biomedich-902	24	1	by	by	ADP
biomedich-902	24	2	boosting	boost	VERB
biomedich-902	24	3	glucose	glucose	NOUN
biomedich-902	24	4	absorption	absorption	NOUN
biomedich-902	24	5	and	and	CCONJ
biomedich-902	24	6	encouraging	encourage	VERB
biomedich-902	24	7	the	the	DET
biomedich-902	24	8	production	production	NOUN
biomedich-902	24	9	of	of	ADP
biomedich-902	24	10	glycogen	glycogen	NOUN
biomedich-902	24	11	in	in	ADP
biomedich-902	24	12	the	the	DET
biomedich-902	24	13	liver	liver	NOUN
biomedich-902	24	14	,	,	PUNCT
biomedich-902	24	15	muscles	muscle	NOUN
biomedich-902	24	16	,	,	PUNCT
biomedich-902	24	17	and	and	CCONJ
biomedich-902	24	18	adipose	adipose	ADJ
biomedich-902	24	19	tissues	tissue	NOUN
biomedich-902	24	20	,	,	PUNCT
biomedich-902	24	21	it	it	PRON
biomedich-902	24	22	has	have	AUX
biomedich-902	24	23	shown	show	VERB
biomedich-902	24	24	strong	strong	ADJ
biomedich-902	24	25	hypoglycemic	hypoglycemic	ADJ
biomedich-902	24	26	effects	effect	NOUN
biomedich-902	24	27	.	.	PUNCT
biomedich-902	25	1	according	accord	VERB
biomedich-902	25	2	to	to	ADP
biomedich-902	25	3	some	some	DET
biomedich-902	25	4	research	research	NOUN
biomedich-902	25	5	,	,	PUNCT
biomedich-902	25	6	charantin	charantin	PROPN
biomedich-902	25	7	may	may	AUX
biomedich-902	25	8	work	work	VERB
biomedich-902	25	9	better	well	ADV
biomedich-902	25	10	than	than	ADP
biomedich-902	25	11	some	some	DET
biomedich-902	25	12	oral	oral	ADJ
biomedich-902	25	13	hypoglycemic	hypoglycemic	ADJ
biomedich-902	25	14	medications	medication	NOUN
biomedich-902	25	15	,	,	PUNCT
biomedich-902	25	16	such	such	ADJ
biomedich-902	25	17	as	as	ADP
biomedich-902	25	18	tolbutamide	tolbutamide	NOUN
biomedich-902	25	19	.	.	PUNCT
biomedich-902	26	1	it	it	PRON
biomedich-902	26	2	is	be	AUX
biomedich-902	26	3	thought	think	VERB
biomedich-902	26	4	to	to	PART
biomedich-902	26	5	work	work	VERB
biomedich-902	26	6	similarly	similarly	ADV
biomedich-902	26	7	to	to	ADP
biomedich-902	26	8	insulin	insulin	NOUN
biomedich-902	26	9	,	,	PUNCT
biomedich-902	26	10	improving	improve	VERB
biomedich-902	26	11	insulin	insulin	NOUN
biomedich-902	26	12	sensitivity	sensitivity	NOUN
biomedich-902	26	13	and	and	CCONJ
biomedich-902	26	14	glucose	glucose	NOUN
biomedich-902	26	15	metabolism	metabolism	NOUN
biomedich-902	26	16	to	to	PART
biomedich-902	26	17	assist	assist	VERB
biomedich-902	26	18	control	control	NOUN
biomedich-902	26	19	blood	blood	NOUN
biomedich-902	26	20	sugar	sugar	NOUN
biomedich-902	26	21	levels	level	NOUN
biomedich-902	26	22	.	.	PUNCT
biomedich-902	27	1	charantin	charantin	PROPN
biomedich-902	27	2	's	's	PART
biomedich-902	27	3	individual	individual	ADJ
biomedich-902	27	4	components	component	NOUN
biomedich-902	27	5	,	,	PUNCT
biomedich-902	27	6	however	however	ADV
biomedich-902	27	7	,	,	PUNCT
biomedich-902	27	8	had	have	VERB
biomedich-902	27	9	less	less	ADJ
biomedich-902	27	10	of	of	ADP
biomedich-902	27	11	an	an	DET
biomedich-902	27	12	impact	impact	NOUN
biomedich-902	27	13	,	,	PUNCT
biomedich-902	27	14	suggesting	suggest	VERB
biomedich-902	27	15	that	that	SCONJ
biomedich-902	27	16	the	the	DET
biomedich-902	27	17	mixture	mixture	NOUN
biomedich-902	27	18	or	or	CCONJ
biomedich-902	27	19	other	other	ADJ
biomedich-902	27	20	unknown	unknown	ADJ
biomedich-902	27	21	elements	element	NOUN
biomedich-902	27	22	may	may	AUX
biomedich-902	27	23	be	be	AUX
biomedich-902	27	24	https://doi.org/10.14421/biomedich.2025.142.1105-1110	https://doi.org/10.14421/biomedich.2025.142.1105-1110	PROPN
biomedich-902	27	25	1106	1106	NUM
biomedich-902	27	26	biology	biology	NOUN
biomedich-902	27	27	,	,	PUNCT
biomedich-902	27	28	medicine	medicine	NOUN
biomedich-902	27	29	,	,	PUNCT
biomedich-902	27	30	&	&	CCONJ
biomedich-902	27	31	natural	natural	ADJ
biomedich-902	27	32	product	product	NOUN
biomedich-902	27	33	chemistry	chemistry	NOUN
biomedich-902	27	34	14	14	NUM
biomedich-902	27	35	(	(	PUNCT
biomedich-902	27	36	2	2	NUM
biomedich-902	27	37	)	)	PUNCT
biomedich-902	27	38	,	,	PUNCT
biomedich-902	27	39	2025	2025	NUM
biomedich-902	27	40	:	:	PUNCT
biomedich-902	27	41	1105	1105	NUM
biomedich-902	27	42	-	-	SYM
biomedich-902	27	43	1110	1110	NUM
biomedich-902	27	44	responsible	responsible	ADJ
biomedich-902	27	45	for	for	ADP
biomedich-902	27	46	some	some	PRON
biomedich-902	27	47	of	of	ADP
biomedich-902	27	48	its	its	PRON
biomedich-902	27	49	effectiveness.(desai	effectiveness.(desai	NOUN
biomedich-902	27	50	&	&	CCONJ
biomedich-902	27	51	tatke	tatke	NOUN
biomedich-902	27	52	,	,	PUNCT
biomedich-902	27	53	2015	2015	NUM
biomedich-902	27	54	)	)	PUNCT
biomedich-902	27	55	vicine	vicine	NOUN
biomedich-902	27	56	although	although	SCONJ
biomedich-902	27	57	it	it	PRON
biomedich-902	27	58	is	be	AUX
biomedich-902	27	59	not	not	PART
biomedich-902	27	60	as	as	ADV
biomedich-902	27	61	well	well	ADV
biomedich-902	27	62	understood	understand	VERB
biomedich-902	27	63	as	as	ADP
biomedich-902	27	64	charantin	charantin	NOUN
biomedich-902	27	65	,	,	PUNCT
biomedich-902	27	66	another	another	DET
biomedich-902	27	67	component	component	NOUN
biomedich-902	27	68	of	of	ADP
biomedich-902	27	69	bitter	bitter	ADJ
biomedich-902	27	70	melon	melon	NOUN
biomedich-902	27	71	also	also	ADV
biomedich-902	27	72	exhibits	exhibit	VERB
biomedich-902	27	73	hypoglycemic	hypoglycemic	ADJ
biomedich-902	27	74	action	action	NOUN
biomedich-902	27	75	.	.	PUNCT
biomedich-902	28	1	both	both	DET
biomedich-902	28	2	substances	substance	NOUN
biomedich-902	28	3	support	support	VERB
biomedich-902	28	4	the	the	DET
biomedich-902	28	5	general	general	ADJ
biomedich-902	28	6	glucose	glucose	NOUN
biomedich-902	28	7	-	-	PUNCT
biomedich-902	28	8	lowering	lower	VERB
biomedich-902	28	9	benefits	benefit	NOUN
biomedich-902	28	10	of	of	ADP
biomedich-902	28	11	bitter	bitter	ADJ
biomedich-902	28	12	melon	melon	NOUN
biomedich-902	28	13	,	,	PUNCT
biomedich-902	28	14	which	which	PRON
biomedich-902	28	15	include	include	VERB
biomedich-902	28	16	enhancing	enhance	VERB
biomedich-902	28	17	insulin	insulin	NOUN
biomedich-902	28	18	receptor	receptor	NOUN
biomedich-902	28	19	sensitivity	sensitivity	NOUN
biomedich-902	28	20	and	and	CCONJ
biomedich-902	28	21	encouraging	encourage	VERB
biomedich-902	28	22	glucose	glucose	NOUN
biomedich-902	28	23	absorption	absorption	NOUN
biomedich-902	28	24	.	.	PUNCT
biomedich-902	29	1	(	(	PUNCT
biomedich-902	29	2	shown	show	VERB
biomedich-902	29	3	in	in	ADP
biomedich-902	29	4	figure	figure	NOUN
biomedich-902	29	5	1	1	NUM
biomedich-902	29	6	)	)	PUNCT
biomedich-902	29	7	many	many	ADJ
biomedich-902	29	8	of	of	ADP
biomedich-902	29	9	the	the	DET
biomedich-902	29	10	conventional	conventional	ADJ
biomedich-902	29	11	and	and	CCONJ
biomedich-902	29	12	experimental	experimental	ADJ
biomedich-902	29	13	applications	application	NOUN
biomedich-902	29	14	of	of	ADP
biomedich-902	29	15	bitter	bitter	ADJ
biomedich-902	29	16	melon	melon	NOUN
biomedich-902	29	17	for	for	ADP
biomedich-902	29	18	the	the	DET
biomedich-902	29	19	treatment	treatment	NOUN
biomedich-902	29	20	of	of	ADP
biomedich-902	29	21	diabetes	diabetes	NOUN
biomedich-902	29	22	are	be	AUX
biomedich-902	29	23	supported	support	VERB
biomedich-902	29	24	by	by	ADP
biomedich-902	29	25	the	the	DET
biomedich-902	29	26	combined	combine	VERB
biomedich-902	29	27	effects	effect	NOUN
biomedich-902	29	28	of	of	ADP
biomedich-902	29	29	vicine	vicine	NOUN
biomedich-902	29	30	and	and	CCONJ
biomedich-902	29	31	charantin	charantin	NOUN
biomedich-902	29	32	.	.	PUNCT
biomedich-902	30	1	their	their	PRON
biomedich-902	30	2	functions	function	NOUN
biomedich-902	30	3	in	in	ADP
biomedich-902	30	4	enhancing	enhance	VERB
biomedich-902	30	5	insulin	insulin	NOUN
biomedich-902	30	6	signaling	signal	VERB
biomedich-902	30	7	,	,	PUNCT
biomedich-902	30	8	reducing	reduce	VERB
biomedich-902	30	9	blood	blood	NOUN
biomedich-902	30	10	glucose	glucose	NOUN
biomedich-902	30	11	levels	level	NOUN
biomedich-902	30	12	,	,	PUNCT
biomedich-902	30	13	and	and	CCONJ
biomedich-902	30	14	possibly	possibly	ADV
biomedich-902	30	15	providing	provide	VERB
biomedich-902	30	16	safer	safe	ADJ
biomedich-902	30	17	substitutes	substitute	NOUN
biomedich-902	30	18	or	or	CCONJ
biomedich-902	30	19	supplements	supplement	NOUN
biomedich-902	30	20	to	to	ADP
biomedich-902	30	21	traditional	traditional	ADJ
biomedich-902	30	22	diabetic	diabetic	ADJ
biomedich-902	30	23	treatments	treatment	NOUN
biomedich-902	30	24	are	be	AUX
biomedich-902	30	25	all	all	PRON
biomedich-902	30	26	supported	support	VERB
biomedich-902	30	27	by	by	ADP
biomedich-902	30	28	research	research	NOUN
biomedich-902	30	29	.	.	PUNCT
biomedich-902	31	1	though	though	SCONJ
biomedich-902	31	2	encouraging	encouraging	ADJ
biomedich-902	31	3	,	,	PUNCT
biomedich-902	31	4	more	more	ADV
biomedich-902	31	5	thorough	thorough	ADJ
biomedich-902	31	6	research	research	NOUN
biomedich-902	31	7	is	be	AUX
biomedich-902	31	8	required	require	VERB
biomedich-902	31	9	to	to	PART
biomedich-902	31	10	completely	completely	ADV
biomedich-902	31	11	understand	understand	VERB
biomedich-902	31	12	their	their	PRON
biomedich-902	31	13	mechanisms	mechanism	NOUN
biomedich-902	31	14	and	and	CCONJ
biomedich-902	31	15	maximize	maximize	VERB
biomedich-902	31	16	their	their	PRON
biomedich-902	31	17	therapeutic	therapeutic	ADJ
biomedich-902	31	18	application	application	NOUN
biomedich-902	31	19	.	.	PUNCT
biomedich-902	32	1	(	(	PUNCT
biomedich-902	32	2	a	a	X
biomedich-902	32	3	)	)	PUNCT
biomedich-902	32	4	(	(	PUNCT
biomedich-902	32	5	b	b	X
biomedich-902	32	6	)	)	PUNCT
biomedich-902	32	7	figure	figure	NOUN
biomedich-902	32	8	1	1	NUM
biomedich-902	32	9	insulin	insulin	NOUN
biomedich-902	32	10	-	-	PUNCT
biomedich-902	32	11	like	like	ADJ
biomedich-902	32	12	compounds	compound	NOUN
biomedich-902	32	13	in	in	ADP
biomedich-902	32	14	bitter	bitter	ADJ
biomedich-902	32	15	melon	melon	NOUN
biomedich-902	32	16	a	a	DET
biomedich-902	32	17	)	)	PUNCT
biomedich-902	32	18	vicine	vicine	NOUN
biomedich-902	32	19	,	,	PUNCT
biomedich-902	32	20	b	b	NOUN
biomedich-902	32	21	)	)	PUNCT
biomedich-902	32	22	charantin	charantin	NOUN
biomedich-902	32	23	.	.	PUNCT
biomedich-902	33	1	(	(	PUNCT
biomedich-902	33	2	a	a	X
biomedich-902	33	3	)	)	PUNCT
biomedich-902	33	4	(	(	PUNCT
biomedich-902	33	5	b	b	X
biomedich-902	33	6	)	)	PUNCT
biomedich-902	33	7	figure	figure	NOUN
biomedich-902	33	8	2	2	NUM
biomedich-902	33	9	.	.	PUNCT
biomedich-902	33	10	a	a	X
biomedich-902	33	11	)	)	PUNCT
biomedich-902	33	12	insulin	insulin	NOUN
biomedich-902	33	13	receptor	receptor	NOUN
biomedich-902	33	14	(	(	PUNCT
biomedich-902	33	15	pdb	pdb	PROPN
biomedich-902	33	16	i	i	PROPN
biomedich-902	33	17	d	d	PROPN
biomedich-902	33	18	:	:	PUNCT
biomedich-902	33	19	1ir3	1ir3	NUM
biomedich-902	33	20	)	)	SYM
biomedich-902	33	21	b	b	NOUN
biomedich-902	33	22	)	)	PUNCT
biomedich-902	33	23	gsk-3	gsk-3	NOUN
biomedich-902	33	24	protein	protein	NOUN
biomedich-902	33	25	(	(	PUNCT
biomedich-902	33	26	pdb	pdb	PROPN
biomedich-902	33	27	i	i	PROPN
biomedich-902	33	28	d	d	PROPN
biomedich-902	33	29	:	:	PUNCT
biomedich-902	33	30	1q5k	1q5k	NUM
biomedich-902	33	31	)	)	PUNCT
biomedich-902	33	32	(	(	PUNCT
biomedich-902	33	33	denzel	denzel	PROPN
biomedich-902	33	34	&	&	CCONJ
biomedich-902	33	35	kästner	kästner	PROPN
biomedich-902	33	36	,	,	PUNCT
biomedich-902	33	37	2018	2018	NUM
biomedich-902	33	38	;	;	PUNCT
biomedich-902	33	39	ullah	ullah	PROPN
biomedich-902	33	40	et	et	PROPN
biomedich-902	33	41	al	al	PROPN
biomedich-902	33	42	.	.	PROPN
biomedich-902	33	43	,	,	PUNCT
biomedich-902	33	44	2023	2023	NUM
biomedich-902	33	45	;	;	PUNCT
biomedich-902	34	1	zahid	zahid	PROPN
biomedich-902	34	2	et	et	PROPN
biomedich-902	34	3	al	al	PROPN
biomedich-902	34	4	.	.	PROPN
biomedich-902	34	5	,	,	PUNCT
biomedich-902	34	6	2019	2019	NUM
biomedich-902	34	7	)	)	PUNCT
biomedich-902	34	8	.	.	PUNCT
biomedich-902	35	1	insulin	insulin	NOUN
biomedich-902	35	2	receptor	receptor	NOUN
biomedich-902	35	3	two	two	NUM
biomedich-902	35	4	α	α	NOUN
biomedich-902	35	5	-	-	NOUN
biomedich-902	35	6	subunits	subunit	NOUN
biomedich-902	35	7	that	that	PRON
biomedich-902	35	8	bind	bind	VERB
biomedich-902	35	9	insulin	insulin	NOUN
biomedich-902	35	10	and	and	CCONJ
biomedich-902	35	11	two	two	NUM
biomedich-902	35	12	β	β	NOUN
biomedich-902	35	13	-	-	NOUN
biomedich-902	35	14	subunits	subunit	NOUN
biomedich-902	35	15	that	that	PRON
biomedich-902	35	16	have	have	VERB
biomedich-902	35	17	tyrosine	tyrosine	PROPN
biomedich-902	35	18	kinase	kinase	PROPN
biomedich-902	35	19	activity	activity	NOUN
biomedich-902	35	20	make	make	VERB
biomedich-902	35	21	up	up	ADP
biomedich-902	35	22	the	the	DET
biomedich-902	35	23	transmembrane	transmembrane	ADJ
biomedich-902	35	24	protein	protein	NOUN
biomedich-902	35	25	known	know	VERB
biomedich-902	35	26	as	as	ADP
biomedich-902	35	27	the	the	DET
biomedich-902	35	28	insulin	insulin	NOUN
biomedich-902	35	29	receptor	receptor	NOUN
biomedich-902	35	30	(	(	PUNCT
biomedich-902	35	31	show	show	NOUN
biomedich-902	35	32	in	in	ADP
biomedich-902	35	33	figure	figure	NOUN
biomedich-902	35	34	2	2	NUM
biomedich-902	35	35	)	)	PUNCT
biomedich-902	35	36	.	.	PUNCT
biomedich-902	36	1	insulin	insulin	NOUN
biomedich-902	36	2	binding	bind	VERB
biomedich-902	36	3	causes	cause	VERB
biomedich-902	36	4	autophosphorylation	autophosphorylation	NOUN
biomedich-902	36	5	of	of	ADP
biomedich-902	36	6	receptors	receptor	NOUN
biomedich-902	36	7	,	,	PUNCT
biomedich-902	36	8	which	which	PRON
biomedich-902	36	9	starts	start	VERB
biomedich-902	36	10	signaling	signal	VERB
biomedich-902	36	11	pathways	pathway	NOUN
biomedich-902	36	12	that	that	PRON
biomedich-902	36	13	improve	improve	VERB
biomedich-902	36	14	tissue	tissue	NOUN
biomedich-902	36	15	metabolism	metabolism	NOUN
biomedich-902	36	16	,	,	PUNCT
biomedich-902	36	17	glucose	glucose	NOUN
biomedich-902	36	18	absorption	absorption	NOUN
biomedich-902	36	19	,	,	PUNCT
biomedich-902	36	20	and	and	CCONJ
biomedich-902	36	21	glycogen	glycogen	NOUN
biomedich-902	36	22	formation	formation	NOUN
biomedich-902	36	23	.	.	PUNCT
biomedich-902	37	1	diabetes	diabetes	NOUN
biomedich-902	37	2	and	and	CCONJ
biomedich-902	37	3	insulin	insulin	NOUN
biomedich-902	37	4	resistance	resistance	NOUN
biomedich-902	37	5	are	be	AUX
biomedich-902	37	6	exacerbated	exacerbate	VERB
biomedich-902	37	7	by	by	ADP
biomedich-902	37	8	impaired	impaired	ADJ
biomedich-902	37	9	insulin	insulin	NOUN
biomedich-902	37	10	receptor	receptor	NOUN
biomedich-902	37	11	activity	activity	NOUN
biomedich-902	37	12	.	.	PUNCT
biomedich-902	38	1	it	it	PRON
biomedich-902	38	2	serves	serve	VERB
biomedich-902	38	3	as	as	ADP
biomedich-902	38	4	a	a	DET
biomedich-902	38	5	crucial	crucial	ADJ
biomedich-902	38	6	molecular	molecular	ADJ
biomedich-902	38	7	switch	switch	NOUN
biomedich-902	38	8	that	that	PRON
biomedich-902	38	9	transforms	transform	VERB
biomedich-902	38	10	the	the	DET
biomedich-902	38	11	presence	presence	NOUN
biomedich-902	38	12	of	of	ADP
biomedich-902	38	13	insulin	insulin	NOUN
biomedich-902	38	14	into	into	ADP
biomedich-902	38	15	reactions	reaction	NOUN
biomedich-902	38	16	that	that	PRON
biomedich-902	38	17	control	control	VERB
biomedich-902	38	18	glucose	glucose	NOUN
biomedich-902	38	19	levels	level	NOUN
biomedich-902	38	20	in	in	ADP
biomedich-902	38	21	cells.(varma	cells.(varma	X
biomedich-902	38	22	narasimha	narasimha	PROPN
biomedich-902	38	23	k	k	PROPN
biomedich-902	38	24	,	,	PUNCT
biomedich-902	38	25	2022	2022	NUM
biomedich-902	38	26	)	)	PUNCT
biomedich-902	38	27	gsk-3	gsk-3	NOUN
biomedich-902	38	28	protein	protein	NOUN
biomedich-902	38	29	by	by	ADP
biomedich-902	38	30	phosphorylating	phosphorylate	VERB
biomedich-902	38	31	glycogen	glycogen	NOUN
biomedich-902	38	32	synthase	synthase	NOUN
biomedich-902	38	33	,	,	PUNCT
biomedich-902	38	34	the	the	DET
biomedich-902	38	35	kinase	kinase	NOUN
biomedich-902	38	36	known	know	VERB
biomedich-902	38	37	as	as	ADP
biomedich-902	38	38	glycogen	glycogen	NOUN
biomedich-902	38	39	synthase	synthase	NOUN
biomedich-902	38	40	kinase-3	kinase-3	PROPN
biomedich-902	38	41	(	(	PUNCT
biomedich-902	38	42	gsk-3	gsk-3	NOUN
biomedich-902	38	43	)	)	PUNCT
biomedich-902	38	44	prevents	prevent	VERB
biomedich-902	38	45	the	the	DET
biomedich-902	38	46	formation	formation	NOUN
biomedich-902	38	47	of	of	ADP
biomedich-902	38	48	glycogen	glycogen	NOUN
biomedich-902	38	49	.	.	PUNCT
biomedich-902	39	1	insulin	insulin	NOUN
biomedich-902	39	2	promotes	promote	VERB
biomedich-902	39	3	the	the	DET
biomedich-902	39	4	synthesis	synthesis	NOUN
biomedich-902	39	5	of	of	ADP
biomedich-902	39	6	glycogen	glycogen	NOUN
biomedich-902	39	7	and	and	CCONJ
biomedich-902	39	8	the	the	DET
biomedich-902	39	9	absorption	absorption	NOUN
biomedich-902	39	10	of	of	ADP
biomedich-902	39	11	glucose	glucose	NOUN
biomedich-902	39	12	by	by	ADP
biomedich-902	39	13	deactivating	deactivate	VERB
biomedich-902	39	14	gsk-3	gsk-3	NOUN
biomedich-902	39	15	through	through	ADP
biomedich-902	39	16	the	the	DET
biomedich-902	39	17	pi3k	pi3k	PROPN
biomedich-902	39	18	/	/	SYM
biomedich-902	39	19	akt	akt	PROPN
biomedich-902	39	20	pathway	pathway	NOUN
biomedich-902	39	21	.	.	PUNCT
biomedich-902	40	1	insulin	insulin	NOUN
biomedich-902	40	2	resistance	resistance	NOUN
biomedich-902	40	3	results	result	NOUN
biomedich-902	40	4	from	from	ADP
biomedich-902	40	5	overactive	overactive	ADJ
biomedich-902	40	6	gsk-3	gsk-3	NOUN
biomedich-902	40	7	,	,	PUNCT
biomedich-902	40	8	which	which	PRON
biomedich-902	40	9	also	also	ADV
biomedich-902	40	10	disrupts	disrupt	VERB
biomedich-902	40	11	insulin	insulin	NOUN
biomedich-902	40	12	signaling	signal	VERB
biomedich-902	40	13	.	.	PUNCT
biomedich-902	41	1	as	as	ADP
biomedich-902	41	2	a	a	DET
biomedich-902	41	3	result	result	NOUN
biomedich-902	41	4	,	,	PUNCT
biomedich-902	41	5	gsk-3	gsk-3	DET
biomedich-902	41	6	inhibition	inhibition	NOUN
biomedich-902	41	7	improves	improve	VERB
biomedich-902	41	8	insulin	insulin	NOUN
biomedich-902	41	9	sensitivity	sensitivity	NOUN
biomedich-902	41	10	and	and	CCONJ
biomedich-902	41	11	is	be	AUX
biomedich-902	41	12	a	a	DET
biomedich-902	41	13	crucial	crucial	ADJ
biomedich-902	41	14	target	target	NOUN
biomedich-902	41	15	for	for	ADP
biomedich-902	41	16	the	the	DET
biomedich-902	41	17	management	management	NOUN
biomedich-902	41	18	of	of	ADP
biomedich-902	41	19	diabetes.(hazarika	diabetes.(hazarika	X
biomedich-902	41	20	et	et	PROPN
biomedich-902	41	21	al	al	PROPN
biomedich-902	41	22	.	.	PROPN
biomedich-902	41	23	,	,	PUNCT
biomedich-902	41	24	2012	2012	NUM
biomedich-902	41	25	;	;	PUNCT
biomedich-902	42	1	pandey	pandey	PROPN
biomedich-902	42	2	&	&	CCONJ
biomedich-902	42	3	degrado	degrado	PROPN
biomedich-902	42	4	,	,	PUNCT
biomedich-902	42	5	2016	2016	NUM
biomedich-902	42	6	;	;	PUNCT
biomedich-902	42	7	ullah	ullah	PROPN
biomedich-902	42	8	et	et	PROPN
biomedich-902	42	9	al	al	PROPN
biomedich-902	42	10	.	.	PROPN
biomedich-902	42	11	,	,	PUNCT
biomedich-902	42	12	2023	2023	NUM
biomedich-902	42	13	)	)	PUNCT
biomedich-902	42	14	molecular	molecular	ADJ
biomedich-902	42	15	docking	dock	VERB
biomedich-902	42	16	a	a	DET
biomedich-902	42	17	popular	popular	ADJ
biomedich-902	42	18	computational	computational	ADJ
biomedich-902	42	19	method	method	NOUN
biomedich-902	42	20	in	in	ADP
biomedich-902	42	21	drug	drug	NOUN
biomedich-902	42	22	development	development	NOUN
biomedich-902	42	23	,	,	PUNCT
biomedich-902	42	24	molecular	molecular	ADJ
biomedich-902	42	25	docking	docking	NOUN
biomedich-902	42	26	simulates	simulate	VERB
biomedich-902	42	27	the	the	DET
biomedich-902	42	28	interaction	interaction	NOUN
biomedich-902	42	29	between	between	ADP
biomedich-902	42	30	a	a	DET
biomedich-902	42	31	target	target	NOUN
biomedich-902	42	32	macromolecule	macromolecule	NOUN
biomedich-902	42	33	,	,	PUNCT
biomedich-902	42	34	like	like	ADP
biomedich-902	42	35	a	a	DET
biomedich-902	42	36	protein	protein	NOUN
biomedich-902	42	37	,	,	PUNCT
biomedich-902	42	38	and	and	CCONJ
biomedich-902	42	39	a	a	DET
biomedich-902	42	40	small	small	ADJ
biomedich-902	42	41	molecule	molecule	NOUN
biomedich-902	42	42	(	(	PUNCT
biomedich-902	42	43	ligand	ligand	NOUN
biomedich-902	42	44	)	)	PUNCT
biomedich-902	42	45	to	to	PART
biomedich-902	42	46	determine	determine	VERB
biomedich-902	42	47	the	the	DET
biomedich-902	42	48	optimal	optimal	ADJ
biomedich-902	42	49	binding	bind	VERB
biomedich-902	42	50	orientation	orientation	NOUN
biomedich-902	42	51	,	,	PUNCT
biomedich-902	42	52	or	or	CCONJ
biomedich-902	42	53	"	"	PUNCT
biomedich-902	42	54	pose	pose	VERB
biomedich-902	42	55	.	.	PUNCT
biomedich-902	42	56	"	"	PUNCT
biomedich-902	42	57	drug	drug	NOUN
biomedich-902	42	58	candidate	candidate	NOUN
biomedich-902	42	59	creation	creation	NOUN
biomedich-902	42	60	and	and	CCONJ
biomedich-902	42	61	optimization	optimization	NOUN
biomedich-902	42	62	are	be	AUX
biomedich-902	42	63	guided	guide	VERB
biomedich-902	42	64	by	by	ADP
biomedich-902	42	65	the	the	DET
biomedich-902	42	66	estimation	estimation	NOUN
biomedich-902	42	67	of	of	ADP
biomedich-902	42	68	the	the	DET
biomedich-902	42	69	ligandtarget	ligandtarget	NOUN
biomedich-902	42	70	complex	complex	NOUN
biomedich-902	42	71	's	's	PART
biomedich-902	42	72	binding	bind	VERB
biomedich-902	42	73	affinity	affinity	NOUN
biomedich-902	42	74	and	and	CCONJ
biomedich-902	42	75	stability	stability	NOUN
biomedich-902	42	76	.	.	PUNCT
biomedich-902	43	1	in	in	ADP
biomedich-902	43	2	molecular	molecular	ADJ
biomedich-902	43	3	docking	docking	NOUN
biomedich-902	43	4	,	,	PUNCT
biomedich-902	43	5	the	the	DET
biomedich-902	43	6	target	target	NOUN
biomedich-902	43	7	and	and	CCONJ
biomedich-902	43	8	ligand	ligand	NOUN
biomedich-902	43	9	structures	structure	NOUN
biomedich-902	43	10	are	be	AUX
biomedich-902	43	11	prepared	prepare	VERB
biomedich-902	43	12	,	,	PUNCT
biomedich-902	43	13	the	the	DET
biomedich-902	43	14	docking	docking	NOUN
biomedich-902	43	15	simulation	simulation	NOUN
biomedich-902	43	16	is	be	AUX
biomedich-902	43	17	carried	carry	VERB
biomedich-902	43	18	out	out	ADP
biomedich-902	43	19	using	use	VERB
biomedich-902	43	20	algorithms	algorithm	NOUN
biomedich-902	43	21	and	and	CCONJ
biomedich-902	43	22	scoring	scoring	NOUN
biomedich-902	43	23	functions	function	NOUN
biomedich-902	43	24	,	,	PUNCT
biomedich-902	43	25	and	and	CCONJ
biomedich-902	43	26	the	the	DET
biomedich-902	43	27	outcomes	outcome	NOUN
biomedich-902	43	28	are	be	AUX
biomedich-902	43	29	assessed	assess	VERB
biomedich-902	43	30	for	for	ADP
biomedich-902	43	31	the	the	DET
biomedich-902	43	32	most	most	ADV
biomedich-902	43	33	advantageous	advantageous	ADJ
biomedich-902	43	34	couplings	coupling	NOUN
biomedich-902	43	35	.	.	PUNCT
biomedich-902	44	1	this	this	DET
biomedich-902	44	2	approach	approach	NOUN
biomedich-902	44	3	is	be	AUX
biomedich-902	44	4	essential	essential	ADJ
biomedich-902	44	5	for	for	SCONJ
biomedich-902	44	6	both	both	DET
biomedich-902	44	7	optimizing	optimize	VERB
biomedich-902	44	8	leads	lead	NOUN
biomedich-902	44	9	in	in	ADP
biomedich-902	44	10	structure	structure	NOUN
biomedich-902	44	11	-	-	PUNCT
biomedich-902	44	12	based	base	VERB
biomedich-902	44	13	drug	drug	NOUN
biomedich-902	44	14	creation	creation	NOUN
biomedich-902	44	15	and	and	CCONJ
biomedich-902	44	16	comprehending	comprehend	VERB
biomedich-902	44	17	molecular	molecular	ADJ
biomedich-902	44	18	recognition.(denzel	recognition.(denzel	NOUN
biomedich-902	44	19	&	&	CCONJ
biomedich-902	44	20	kästner	kästner	PROPN
biomedich-902	44	21	,	,	PUNCT
biomedich-902	44	22	2018	2018	NUM
biomedich-902	44	23	;	;	PUNCT
biomedich-902	44	24	hase	hase	PROPN
biomedich-902	44	25	&	&	CCONJ
biomedich-902	44	26	scuseria	scuseria	PROPN
biomedich-902	44	27	,	,	PUNCT
biomedich-902	44	28	2003	2003	NUM
biomedich-902	44	29	;	;	PUNCT
biomedich-902	44	30	klein	klein	PROPN
biomedich-902	44	31	&	&	CCONJ
biomedich-902	44	32	lukeš	lukeš	PROPN
biomedich-902	44	33	,	,	PUNCT
biomedich-902	44	34	2006	2006	NUM
biomedich-902	44	35	;	;	PUNCT
biomedich-902	44	36	schlegel	schlegel	PROPN
biomedich-902	44	37	,	,	PUNCT
biomedich-902	44	38	2011	2011	NUM
biomedich-902	44	39	)	)	PUNCT
biomedich-902	44	40	this	this	DET
biomedich-902	44	41	study	study	NOUN
biomedich-902	44	42	explores	explore	VERB
biomedich-902	44	43	the	the	DET
biomedich-902	44	44	toxicity	toxicity	NOUN
biomedich-902	44	45	profiles	profile	NOUN
biomedich-902	44	46	of	of	ADP
biomedich-902	44	47	vicine	vicine	NOUN
biomedich-902	44	48	and	and	CCONJ
biomedich-902	44	49	charantin	charantin	NOUN
biomedich-902	44	50	,	,	PUNCT
biomedich-902	44	51	determines	determine	VERB
biomedich-902	44	52	which	which	PRON
biomedich-902	44	53	phytochemical	phytochemical	ADJ
biomedich-902	44	54	in	in	ADP
biomedich-902	44	55	bitter	bitter	ADJ
biomedich-902	44	56	melon	melon	NOUN
biomedich-902	44	57	lowers	lower	VERB
biomedich-902	44	58	blood	blood	NOUN
biomedich-902	44	59	glucose	glucose	NOUN
biomedich-902	44	60	levels	level	NOUN
biomedich-902	44	61	by	by	ADP
biomedich-902	44	62	which	which	PRON
biomedich-902	44	63	particular	particular	ADJ
biomedich-902	44	64	pathway	pathway	NOUN
biomedich-902	44	65	,	,	PUNCT
biomedich-902	44	66	and	and	CCONJ
biomedich-902	44	67	assesses	assesse	NOUN
biomedich-902	44	68	whether	whether	SCONJ
biomedich-902	44	69	charantin	charantin	NOUN
biomedich-902	44	70	can	can	AUX
biomedich-902	44	71	work	work	VERB
biomedich-902	44	72	through	through	ADP
biomedich-902	44	73	both	both	DET
biomedich-902	44	74	the	the	DET
biomedich-902	44	75	gsk-3	gsk-3	ADJ
biomedich-902	44	76	and	and	CCONJ
biomedich-902	44	77	insulin	insulin	NOUN
biomedich-902	44	78	receptor	receptor	NOUN
biomedich-902	44	79	pathways	pathway	NOUN
biomedich-902	44	80	.	.	PUNCT
biomedich-902	45	1	to	to	PART
biomedich-902	45	2	do	do	VERB
biomedich-902	45	3	this	this	PRON
biomedich-902	45	4	,	,	PUNCT
biomedich-902	45	5	the	the	DET
biomedich-902	45	6	binding	bind	VERB
biomedich-902	45	7	affinities	affinity	NOUN
biomedich-902	45	8	of	of	ADP
biomedich-902	45	9	vicine	vicine	NOUN
biomedich-902	45	10	and	and	CCONJ
biomedich-902	45	11	charantin	charantin	VERB
biomedich-902	45	12	with	with	ADP
biomedich-902	45	13	gsk-3	gsk-3	PUNCT
biomedich-902	45	14	and	and	CCONJ
biomedich-902	45	15	the	the	DET
biomedich-902	45	16	insulin	insulin	NOUN
biomedich-902	45	17	receptor	receptor	NOUN
biomedich-902	45	18	were	be	AUX
biomedich-902	45	19	ascertained	ascertain	VERB
biomedich-902	45	20	using	use	VERB
biomedich-902	45	21	computational	computational	ADJ
biomedich-902	45	22	chemistry	chemistry	NOUN
biomedich-902	45	23	.	.	PUNCT
biomedich-902	46	1	the	the	DET
biomedich-902	46	2	antidiabetic	antidiabetic	ADJ
biomedich-902	46	3	processes	process	NOUN
biomedich-902	46	4	of	of	ADP
biomedich-902	46	5	bitter	bitter	ADJ
biomedich-902	46	6	melon	melon	NOUN
biomedich-902	46	7	's	's	PART
biomedich-902	46	8	bioactive	bioactive	NOUN
biomedich-902	46	9	chemicals	chemical	NOUN
biomedich-902	46	10	,	,	PUNCT
biomedich-902	46	11	particularly	particularly	ADV
biomedich-902	46	12	vicine	vicine	ADJ
biomedich-902	46	13	and	and	CCONJ
biomedich-902	46	14	charantin	charantin	NOUN
biomedich-902	46	15	,	,	PUNCT
biomedich-902	46	16	are	be	AUX
biomedich-902	46	17	better	well	ADV
biomedich-902	46	18	understood	understand	VERB
biomedich-902	46	19	thanks	thank	NOUN
biomedich-902	46	20	to	to	ADP
biomedich-902	46	21	this	this	DET
biomedich-902	46	22	study	study	NOUN
biomedich-902	46	23	.	.	PUNCT
biomedich-902	47	1	by	by	ADP
biomedich-902	47	2	evaluating	evaluate	VERB
biomedich-902	47	3	their	their	PRON
biomedich-902	47	4	interactions	interaction	NOUN
biomedich-902	47	5	with	with	ADP
biomedich-902	47	6	two	two	NUM
biomedich-902	47	7	important	important	ADJ
biomedich-902	47	8	targets	target	NOUN
biomedich-902	47	9	gsk-3	gsk-3	NOUN
biomedich-902	47	10	and	and	CCONJ
biomedich-902	47	11	the	the	DET
biomedich-902	47	12	insulin	insulin	NOUN
biomedich-902	47	13	receptor	receptor	NOUN
biomedich-902	47	14	using	use	VERB
biomedich-902	47	15	computational	computational	ADJ
biomedich-902	47	16	chemistry	chemistry	NOUN
biomedich-902	47	17	,	,	PUNCT
biomedich-902	47	18	it	it	PRON
biomedich-902	47	19	becomes	become	VERB
biomedich-902	47	20	clearer	clear	ADJ
biomedich-902	47	21	which	which	PRON
biomedich-902	47	22	routes	route	VERB
biomedich-902	47	23	these	these	DET
biomedich-902	47	24	substances	substance	NOUN
biomedich-902	47	25	use	use	VERB
biomedich-902	47	26	to	to	PART
biomedich-902	47	27	reduce	reduce	VERB
biomedich-902	47	28	blood	blood	NOUN
biomedich-902	47	29	glucose	glucose	NOUN
biomedich-902	47	30	.	.	PUNCT
biomedich-902	48	1	determining	determine	VERB
biomedich-902	48	2	whether	whether	SCONJ
biomedich-902	48	3	charantin	charantin	NOUN
biomedich-902	48	4	can	can	AUX
biomedich-902	48	5	function	function	VERB
biomedich-902	48	6	via	via	ADP
biomedich-902	48	7	both	both	DET
biomedich-902	48	8	pathways	pathway	NOUN
biomedich-902	48	9	provides	provide	VERB
biomedich-902	48	10	a	a	DET
biomedich-902	48	11	basis	basis	NOUN
biomedich-902	48	12	for	for	ADP
biomedich-902	48	13	creating	create	VERB
biomedich-902	48	14	treatments	treatment	NOUN
biomedich-902	48	15	that	that	PRON
biomedich-902	48	16	target	target	VERB
biomedich-902	48	17	both	both	DET
biomedich-902	48	18	pathways	pathway	NOUN
biomedich-902	48	19	.	.	PUNCT
biomedich-902	49	1	assessing	assess	VERB
biomedich-902	49	2	the	the	DET
biomedich-902	49	3	toxicity	toxicity	NOUN
biomedich-902	49	4	profiles	profile	NOUN
biomedich-902	49	5	of	of	ADP
biomedich-902	49	6	these	these	DET
biomedich-902	49	7	substances	substance	NOUN
biomedich-902	49	8	also	also	ADV
biomedich-902	49	9	lends	lend	VERB
biomedich-902	49	10	credence	credence	NOUN
biomedich-902	49	11	to	to	ADP
biomedich-902	49	12	their	their	PRON
biomedich-902	49	13	possible	possible	ADJ
biomedich-902	49	14	safe	safe	ADJ
biomedich-902	49	15	application	application	NOUN
biomedich-902	49	16	as	as	ADP
biomedich-902	49	17	supplements	supplement	NOUN
biomedich-902	49	18	or	or	CCONJ
biomedich-902	49	19	natural	natural	ADJ
biomedich-902	49	20	substitutes	substitute	NOUN
biomedich-902	49	21	for	for	ADP
biomedich-902	49	22	current	current	ADJ
biomedich-902	49	23	diabetes	diabetes	NOUN
biomedich-902	49	24	therapies	therapy	NOUN
biomedich-902	49	25	.	.	PUNCT
biomedich-902	50	1	the	the	DET
biomedich-902	50	2	overall	overall	ADJ
biomedich-902	50	3	goal	goal	NOUN
biomedich-902	50	4	of	of	ADP
biomedich-902	50	5	this	this	DET
biomedich-902	50	6	research	research	NOUN
biomedich-902	50	7	is	be	AUX
biomedich-902	50	8	to	to	PART
biomedich-902	50	9	help	help	AUX
biomedich-902	50	10	find	find	VERB
biomedich-902	50	11	plant	plant	NOUN
biomedich-902	50	12	-	-	PUNCT
biomedich-902	50	13	based	base	VERB
biomedich-902	50	14	treatments	treatment	NOUN
biomedich-902	50	15	for	for	ADP
biomedich-902	50	16	diabetes.(prasangika	diabetes.(prasangika	X
biomedich-902	50	17	et	et	PROPN
biomedich-902	50	18	al	al	PROPN
biomedich-902	50	19	.	.	PROPN
biomedich-902	50	20	,	,	PUNCT
biomedich-902	50	21	2025	2025	NUM
biomedich-902	50	22	;	;	PUNCT
biomedich-902	50	23	sneha	sneha	PROPN
biomedich-902	50	24	et	et	PROPN
biomedich-902	50	25	al	al	PROPN
biomedich-902	50	26	.	.	PROPN
biomedich-902	50	27	,	,	PUNCT
biomedich-902	50	28	2023	2023	NUM
biomedich-902	50	29	)	)	PUNCT
biomedich-902	50	30	materials	material	NOUN
biomedich-902	50	31	and	and	CCONJ
biomedich-902	50	32	methods	method	NOUN
biomedich-902	50	33	study	study	NOUN
biomedich-902	50	34	area	area	NOUN
biomedich-902	50	35	the	the	DET
biomedich-902	50	36	computational	computational	ADJ
biomedich-902	50	37	assessment	assessment	NOUN
biomedich-902	50	38	of	of	ADP
biomedich-902	50	39	antidiabetic	antidiabetic	ADJ
biomedich-902	50	40	phytochemicals	phytochemical	NOUN
biomedich-902	50	41	present	present	ADJ
biomedich-902	50	42	in	in	ADP
biomedich-902	50	43	momordica	momordica	PROPN
biomedich-902	50	44	charantia	charantia	PROPN
biomedich-902	50	45	(	(	PUNCT
biomedich-902	50	46	bitter	bitter	ADJ
biomedich-902	50	47	melon	melon	NOUN
biomedich-902	50	48	)	)	PUNCT
biomedich-902	50	49	is	be	AUX
biomedich-902	50	50	the	the	DET
biomedich-902	50	51	main	main	ADJ
biomedich-902	50	52	objective	objective	NOUN
biomedich-902	50	53	of	of	ADP
biomedich-902	50	54	this	this	DET
biomedich-902	50	55	work	work	NOUN
biomedich-902	50	56	.	.	PUNCT
biomedich-902	51	1	charantin	charantin	NOUN
biomedich-902	51	2	and	and	CCONJ
biomedich-902	51	3	prasangika	prasangika	NOUN
biomedich-902	51	4	–	–	PUNCT
biomedich-902	51	5	bitter	bitter	ADJ
biomedich-902	51	6	melon	melon	NOUN
biomedich-902	51	7	:	:	PUNCT
biomedich-902	51	8	gsk-3	gsk-3	PUNCT
biomedich-902	51	9	and	and	CCONJ
biomedich-902	51	10	ir	ir	PROPN
biomedich-902	51	11	targets	target	NOUN
biomedich-902	51	12	1107	1107	NUM
biomedich-902	51	13	vicine	vicine	NOUN
biomedich-902	51	14	are	be	AUX
biomedich-902	51	15	molecularly	molecularly	ADV
biomedich-902	51	16	docked	dock	VERB
biomedich-902	51	17	with	with	ADP
biomedich-902	51	18	the	the	DET
biomedich-902	51	19	insulin	insulin	NOUN
biomedich-902	51	20	receptor	receptor	NOUN
biomedich-902	51	21	and	and	CCONJ
biomedich-902	51	22	gsk-3	gsk-3	NOUN
biomedich-902	51	23	,	,	PUNCT
biomedich-902	51	24	two	two	NUM
biomedich-902	51	25	important	important	ADJ
biomedich-902	51	26	diabetes	diabetes	NOUN
biomedich-902	51	27	-	-	PUNCT
biomedich-902	51	28	related	relate	VERB
biomedich-902	51	29	proteins	protein	NOUN
biomedich-902	51	30	,	,	PUNCT
biomedich-902	51	31	to	to	PART
biomedich-902	51	32	determine	determine	VERB
biomedich-902	51	33	their	their	PRON
biomedich-902	51	34	toxicity	toxicity	NOUN
biomedich-902	51	35	profiles	profile	NOUN
biomedich-902	51	36	,	,	PUNCT
biomedich-902	51	37	possible	possible	ADJ
biomedich-902	51	38	modes	mode	NOUN
biomedich-902	51	39	of	of	ADP
biomedich-902	51	40	action	action	NOUN
biomedich-902	51	41	,	,	PUNCT
biomedich-902	51	42	and	and	CCONJ
biomedich-902	51	43	binding	bind	VERB
biomedich-902	51	44	affinities	affinity	NOUN
biomedich-902	51	45	.	.	PUNCT
biomedich-902	52	1	procedures	procedure	NOUN
biomedich-902	52	2	all	all	DET
biomedich-902	52	3	the	the	DET
biomedich-902	52	4	computational	computational	ADJ
biomedich-902	52	5	calculations	calculation	NOUN
biomedich-902	52	6	,	,	PUNCT
biomedich-902	52	7	optimizations	optimization	NOUN
biomedich-902	52	8	,	,	PUNCT
biomedich-902	52	9	and	and	CCONJ
biomedich-902	52	10	molecular	molecular	ADJ
biomedich-902	52	11	docking	docking	NOUN
biomedich-902	52	12	studies	study	NOUN
biomedich-902	52	13	were	be	AUX
biomedich-902	52	14	done	do	VERB
biomedich-902	52	15	using	use	VERB
biomedich-902	52	16	a	a	DET
biomedich-902	52	17	workstation	workstation	NOUN
biomedich-902	52	18	with	with	ADP
biomedich-902	52	19	an	an	DET
biomedich-902	52	20	intel	intel	NOUN
biomedich-902	52	21	©	©	PROPN
biomedich-902	52	22	core	core	NOUN
biomedich-902	52	23	i7	i7	ADJ
biomedich-902	52	24	5820k	5820k	NOUN
biomedich-902	52	25	cpu	cpu	NOUN
biomedich-902	52	26	(	(	PUNCT
biomedich-902	52	27	3.3	3.3	NUM
biomedich-902	52	28	-	-	SYM
biomedich-902	52	29	3.6	3.6	NUM
biomedich-902	52	30	ghz	ghz	NOUN
biomedich-902	52	31	)	)	PUNCT
biomedich-902	52	32	and	and	CCONJ
biomedich-902	52	33	32	32	NUM
biomedich-902	52	34	gb	gb	NOUN
biomedich-902	52	35	ram	ram	NOUN
biomedich-902	52	36	,	,	PUNCT
biomedich-902	52	37	and	and	CCONJ
biomedich-902	52	38	the	the	DET
biomedich-902	52	39	processor	processor	NOUN
biomedich-902	52	40	with	with	ADP
biomedich-902	52	41	intel(r	intel(r	PROPN
biomedich-902	52	42	)	)	PUNCT
biomedich-902	52	43	core	core	NOUN
biomedich-902	52	44	(	(	PUNCT
biomedich-902	52	45	tm	tm	NOUN
biomedich-902	52	46	)	)	PUNCT
biomedich-902	52	47	i54570	i54570	NOUN
biomedich-902	52	48	cpu	cpu	NOUN
biomedich-902	52	49	@	@	ADP
biomedich-902	52	50	3.20ghz	3.20ghz	NUM
biomedich-902	52	51	and	and	CCONJ
biomedich-902	52	52	4	4	NUM
biomedich-902	52	53	gb	gb	NOUN
biomedich-902	52	54	ram	ram	NOUN
biomedich-902	52	55	.	.	PUNCT
biomedich-902	53	1	protein	protein	NOUN
biomedich-902	53	2	preparation	preparation	NOUN
biomedich-902	53	3	the	the	DET
biomedich-902	53	4	3d	3d	PROPN
biomedich-902	53	5	structures	structure	NOUN
biomedich-902	53	6	of	of	ADP
biomedich-902	53	7	protein	protein	NOUN
biomedich-902	53	8	molecules	molecule	NOUN
biomedich-902	53	9	were	be	AUX
biomedich-902	53	10	downloaded	download	VERB
biomedich-902	53	11	from	from	ADP
biomedich-902	53	12	the	the	DET
biomedich-902	53	13	protein	protein	NOUN
biomedich-902	53	14	data	data	PROPN
biomedich-902	53	15	bank	bank	PROPN
biomedich-902	53	16	(	(	PUNCT
biomedich-902	53	17	pdb	pdb	PROPN
biomedich-902	53	18	)	)	PUNCT
biomedich-902	53	19	(	(	PUNCT
biomedich-902	53	20	https://www.rcsb.org	https://www.rcsb.org	X
biomedich-902	53	21	)	)	PUNCT
biomedich-902	54	1	(	(	PUNCT
biomedich-902	54	2	pdb	pdb	PROPN
biomedich-902	54	3	i	i	PROPN
biomedich-902	54	4	d	d	PROPN
biomedich-902	54	5	–	–	PUNCT
biomedich-902	54	6	1q5k	1q5k	NUM
biomedich-902	54	7	and	and	CCONJ
biomedich-902	54	8	pdb	pdb	PROPN
biomedich-902	54	9	i	i	PROPN
biomedich-902	54	10	d	d	PROPN
biomedich-902	54	11	1ir3	1ir3	NUM
biomedich-902	54	12	)	)	PUNCT
biomedich-902	54	13	according	accord	VERB
biomedich-902	54	14	to	to	ADP
biomedich-902	54	15	the	the	DET
biomedich-902	54	16	resolution	resolution	NOUN
biomedich-902	54	17	and	and	CCONJ
biomedich-902	54	18	method	method	NOUN
biomedich-902	54	19	(	(	PUNCT
biomedich-902	54	20	x	x	NOUN
biomedich-902	54	21	-	-	NOUN
biomedich-902	54	22	ray	ray	NOUN
biomedich-902	54	23	crystallography	crystallography	NOUN
biomedich-902	54	24	)	)	PUNCT
biomedich-902	54	25	.	.	PUNCT
biomedich-902	55	1	protein	protein	NOUN
biomedich-902	55	2	structures	structure	NOUN
biomedich-902	55	3	were	be	AUX
biomedich-902	55	4	cleaned	clean	VERB
biomedich-902	55	5	by	by	ADP
biomedich-902	55	6	using	use	VERB
biomedich-902	55	7	biovia	biovia	PROPN
biomedich-902	55	8	discovery	discovery	PROPN
biomedich-902	55	9	studio	studio	NOUN
biomedich-902	55	10	2021	2021	NUM
biomedich-902	55	11	.	.	PUNCT
biomedich-902	56	1	all	all	DET
biomedich-902	56	2	water	water	NOUN
biomedich-902	56	3	molecules	molecule	NOUN
biomedich-902	56	4	,	,	PUNCT
biomedich-902	56	5	ligands	ligand	NOUN
biomedich-902	56	6	,	,	PUNCT
biomedich-902	56	7	ions	ion	NOUN
biomedich-902	56	8	and	and	CCONJ
biomedich-902	56	9	heteroatoms	heteroatom	NOUN
biomedich-902	56	10	were	be	AUX
biomedich-902	56	11	removed	remove	VERB
biomedich-902	56	12	from	from	ADP
biomedich-902	56	13	the	the	DET
biomedich-902	56	14	protein	protein	NOUN
biomedich-902	56	15	molecule.from	molecule.from	ADP
biomedich-902	56	16	the	the	DET
biomedich-902	56	17	cleaned	clean	VERB
biomedich-902	56	18	gsk-3	gsk-3	PUNCT
biomedich-902	56	19	whole	whole	ADJ
biomedich-902	56	20	protein	protein	NOUN
biomedich-902	56	21	,	,	PUNCT
biomedich-902	56	22	two	two	NUM
biomedich-902	56	23	distinct	distinct	ADJ
biomedich-902	56	24	protein	protein	NOUN
biomedich-902	56	25	chains	chain	NOUN
biomedich-902	56	26	were	be	AUX
biomedich-902	56	27	separated	separate	VERB
biomedich-902	56	28	.	.	PUNCT
biomedich-902	57	1	gsk-3a	gsk-3a	NOUN
biomedich-902	57	2	and	and	CCONJ
biomedich-902	57	3	gsk-3b	gsk-3b	NOUN
biomedich-902	57	4	.	.	PUNCT
biomedich-902	58	1	the	the	DET
biomedich-902	58	2	ligand	ligand	NOUN
biomedich-902	58	3	was	be	AUX
biomedich-902	58	4	docked	dock	VERB
biomedich-902	58	5	with	with	ADP
biomedich-902	58	6	each	each	PRON
biomedich-902	58	7	of	of	ADP
biomedich-902	58	8	these	these	DET
biomedich-902	58	9	three	three	NUM
biomedich-902	58	10	proteins	protein	NOUN
biomedich-902	58	11	,	,	PUNCT
biomedich-902	58	12	gsk-3	gsk-3	NOUN
biomedich-902	58	13	whole	whole	ADJ
biomedich-902	58	14	protein	protein	NOUN
biomedich-902	58	15	,	,	PUNCT
biomedich-902	58	16	gsk-3a	gsk-3a	NOUN
biomedich-902	58	17	,	,	PUNCT
biomedich-902	58	18	and	and	CCONJ
biomedich-902	58	19	gsk-3b	gsk-3b	NOUN
biomedich-902	58	20	.	.	PUNCT
biomedich-902	59	1	molecular	molecular	ADJ
biomedich-902	59	2	docking	docking	NOUN
biomedich-902	59	3	autodock	autodock	NOUN
biomedich-902	59	4	tools	tool	NOUN
biomedich-902	59	5	1.5.6	1.5.6	NUM
biomedich-902	59	6	and	and	CCONJ
biomedich-902	59	7	autodock	autodock	NOUN
biomedich-902	59	8	4.2	4.2	NUM
biomedich-902	59	9	were	be	AUX
biomedich-902	59	10	used	use	VERB
biomedich-902	59	11	to	to	PART
biomedich-902	59	12	perform	perform	VERB
biomedich-902	59	13	molecular	molecular	ADJ
biomedich-902	59	14	docking	docking	NOUN
biomedich-902	59	15	investigations	investigation	NOUN
biomedich-902	59	16	,	,	PUNCT
biomedich-902	59	17	utilizing	utilize	VERB
biomedich-902	59	18	the	the	DET
biomedich-902	59	19	lamarckian	lamarckian	ADJ
biomedich-902	59	20	genetic	genetic	ADJ
biomedich-902	59	21	algorithm	algorithm	NOUN
biomedich-902	59	22	and	and	CCONJ
biomedich-902	59	23	the	the	DET
biomedich-902	59	24	free	free	ADJ
biomedich-902	59	25	energy	energy	NOUN
biomedich-902	59	26	function	function	NOUN
biomedich-902	59	27	.	.	PUNCT
biomedich-902	60	1	while	while	SCONJ
biomedich-902	60	2	ligands	ligand	NOUN
biomedich-902	60	3	were	be	AUX
biomedich-902	60	4	made	make	VERB
biomedich-902	60	5	with	with	ADP
biomedich-902	60	6	hydrogen	hydrogen	NOUN
biomedich-902	60	7	atoms	atom	NOUN
biomedich-902	60	8	and	and	CCONJ
biomedich-902	60	9	gasteiger	gasteiger	NOUN
biomedich-902	60	10	charges	charge	NOUN
biomedich-902	60	11	,	,	PUNCT
biomedich-902	60	12	protein	protein	NOUN
biomedich-902	60	13	structures	structure	NOUN
biomedich-902	60	14	were	be	AUX
biomedich-902	60	15	made	make	VERB
biomedich-902	60	16	with	with	ADP
biomedich-902	60	17	polar	polar	ADJ
biomedich-902	60	18	hydrogen	hydrogen	NOUN
biomedich-902	60	19	and	and	CCONJ
biomedich-902	60	20	kollman	kollman	NOUN
biomedich-902	60	21	charges	charge	NOUN
biomedich-902	60	22	.	.	PUNCT
biomedich-902	61	1	blind	blind	ADJ
biomedich-902	61	2	docking	docking	NOUN
biomedich-902	61	3	was	be	AUX
biomedich-902	61	4	used	use	VERB
biomedich-902	61	5	to	to	PART
biomedich-902	61	6	investigate	investigate	VERB
biomedich-902	61	7	every	every	DET
biomedich-902	61	8	potential	potential	ADJ
biomedich-902	61	9	binding	bind	VERB
biomedich-902	61	10	site	site	NOUN
biomedich-902	61	11	after	after	SCONJ
biomedich-902	61	12	grid	grid	NOUN
biomedich-902	61	13	and	and	CCONJ
biomedich-902	61	14	docking	docking	NOUN
biomedich-902	61	15	parameter	parameter	NOUN
biomedich-902	61	16	files	file	NOUN
biomedich-902	61	17	were	be	AUX
biomedich-902	61	18	created	create	VERB
biomedich-902	61	19	.	.	PUNCT
biomedich-902	62	1	a	a	DET
biomedich-902	62	2	population	population	NOUN
biomedich-902	62	3	of	of	ADP
biomedich-902	62	4	300	300	NUM
biomedich-902	62	5	,	,	PUNCT
biomedich-902	62	6	2,500,000	2,500,000	NUM
biomedich-902	62	7	energy	energy	NOUN
biomedich-902	62	8	evaluations	evaluation	NOUN
biomedich-902	62	9	,	,	PUNCT
biomedich-902	62	10	27,000	27,000	NUM
biomedich-902	62	11	generations	generation	NOUN
biomedich-902	62	12	,	,	PUNCT
biomedich-902	62	13	100	100	NUM
biomedich-902	62	14	genetic	genetic	ADJ
biomedich-902	62	15	algorithm	algorithm	NOUN
biomedich-902	62	16	runs	run	NOUN
biomedich-902	62	17	,	,	PUNCT
biomedich-902	62	18	a	a	DET
biomedich-902	62	19	mutation	mutation	NOUN
biomedich-902	62	20	rate	rate	NOUN
biomedich-902	62	21	of	of	ADP
biomedich-902	62	22	0.02	0.02	NUM
biomedich-902	62	23	,	,	PUNCT
biomedich-902	62	24	and	and	CCONJ
biomedich-902	62	25	a	a	DET
biomedich-902	62	26	crossover	crossover	NOUN
biomedich-902	62	27	rate	rate	NOUN
biomedich-902	62	28	of	of	ADP
biomedich-902	62	29	0.80	0.80	NUM
biomedich-902	62	30	were	be	AUX
biomedich-902	62	31	all	all	PRON
biomedich-902	62	32	used	use	VERB
biomedich-902	62	33	in	in	ADP
biomedich-902	62	34	the	the	DET
biomedich-902	62	35	docking	docking	NOUN
biomedich-902	62	36	process	process	NOUN
biomedich-902	62	37	.	.	PUNCT
biomedich-902	63	1	using	use	VERB
biomedich-902	63	2	identical	identical	ADJ
biomedich-902	63	3	grid	grid	NOUN
biomedich-902	63	4	box	box	NOUN
biomedich-902	63	5	dimensions	dimension	NOUN
biomedich-902	63	6	,	,	PUNCT
biomedich-902	63	7	each	each	DET
biomedich-902	63	8	ligand	ligand	NOUN
biomedich-902	63	9	was	be	AUX
biomedich-902	63	10	docked	dock	VERB
biomedich-902	63	11	to	to	ADP
biomedich-902	63	12	the	the	DET
biomedich-902	63	13	insulin	insulin	NOUN
biomedich-902	63	14	receptor	receptor	NOUN
biomedich-902	63	15	,	,	PUNCT
biomedich-902	63	16	gsk-3	gsk-3	NOUN
biomedich-902	63	17	,	,	PUNCT
biomedich-902	63	18	gsk-3a	gsk-3a	NOUN
biomedich-902	63	19	,	,	PUNCT
biomedich-902	63	20	and	and	CCONJ
biomedich-902	63	21	gsk-3b	gsk-3b	NOUN
biomedich-902	63	22	proteins	protein	NOUN
biomedich-902	63	23	in	in	ADP
biomedich-902	63	24	ten	ten	NUM
biomedich-902	63	25	different	different	ADJ
biomedich-902	63	26	trials	trial	NOUN
biomedich-902	63	27	.	.	PUNCT
biomedich-902	64	1	the	the	DET
biomedich-902	64	2	ligand	ligand	NOUN
biomedich-902	64	3	was	be	AUX
biomedich-902	64	4	flexible	flexible	ADJ
biomedich-902	64	5	,	,	PUNCT
biomedich-902	64	6	but	but	CCONJ
biomedich-902	64	7	the	the	DET
biomedich-902	64	8	protein	protein	NOUN
biomedich-902	64	9	stayed	stay	VERB
biomedich-902	64	10	rigid	rigid	ADJ
biomedich-902	64	11	.	.	PUNCT
biomedich-902	65	1	each	each	DET
biomedich-902	65	2	set	set	NOUN
biomedich-902	65	3	's	's	PART
biomedich-902	65	4	optimal	optimal	ADJ
biomedich-902	65	5	binding	bind	VERB
biomedich-902	65	6	energy	energy	NOUN
biomedich-902	65	7	was	be	AUX
biomedich-902	65	8	chosen	choose	VERB
biomedich-902	65	9	for	for	ADP
biomedich-902	65	10	examination	examination	NOUN
biomedich-902	65	11	.	.	PUNCT
biomedich-902	66	1	the	the	DET
biomedich-902	66	2	docking	docking	NOUN
biomedich-902	66	3	log	log	VERB
biomedich-902	66	4	files	file	NOUN
biomedich-902	66	5	(	(	PUNCT
biomedich-902	66	6	.dlg	.dlg	PROPN
biomedich-902	66	7	)	)	PUNCT
biomedich-902	66	8	were	be	AUX
biomedich-902	66	9	used	use	VERB
biomedich-902	66	10	to	to	PART
biomedich-902	66	11	obtain	obtain	VERB
biomedich-902	66	12	inhibition	inhibition	NOUN
biomedich-902	66	13	constants	constant	NOUN
biomedich-902	66	14	and	and	CCONJ
biomedich-902	66	15	binding	bind	VERB
biomedich-902	66	16	energies	energy	NOUN
biomedich-902	66	17	.	.	PUNCT
biomedich-902	67	1	plip	plip	PROPN
biomedich-902	67	2	and	and	CCONJ
biomedich-902	67	3	discovery	discovery	PROPN
biomedich-902	67	4	studio	studio	NOUN
biomedich-902	67	5	were	be	AUX
biomedich-902	67	6	utilized	utilize	VERB
biomedich-902	67	7	to	to	PART
biomedich-902	67	8	evaluate	evaluate	VERB
biomedich-902	67	9	molecular	molecular	ADJ
biomedich-902	67	10	interactions	interaction	NOUN
biomedich-902	67	11	,	,	PUNCT
biomedich-902	67	12	bond	bond	NOUN
biomedich-902	67	13	lengths	length	NOUN
biomedich-902	67	14	,	,	PUNCT
biomedich-902	67	15	and	and	CCONJ
biomedich-902	67	16	active	active	ADJ
biomedich-902	67	17	site	site	NOUN
biomedich-902	67	18	residues	residue	NOUN
biomedich-902	67	19	;	;	PUNCT
biomedich-902	67	20	pymol	pymol	NOUN
biomedich-902	67	21	was	be	AUX
biomedich-902	67	22	employed	employ	VERB
biomedich-902	67	23	for	for	ADP
biomedich-902	67	24	structural	structural	ADJ
biomedich-902	67	25	analysis	analysis	NOUN
biomedich-902	67	26	and	and	CCONJ
biomedich-902	67	27	visualization	visualization	NOUN
biomedich-902	67	28	.	.	PUNCT
biomedich-902	68	1	control	control	NOUN
biomedich-902	68	2	inhibitor	inhibitor	NOUN
biomedich-902	68	3	of	of	ADP
biomedich-902	68	4	the	the	DET
biomedich-902	68	5	docking	docking	NOUN
biomedich-902	68	6	approach	approach	NOUN
biomedich-902	68	7	inhibitors	inhibitor	NOUN
biomedich-902	68	8	are	be	AUX
biomedich-902	68	9	commonly	commonly	ADV
biomedich-902	68	10	found	find	VERB
biomedich-902	68	11	in	in	ADP
biomedich-902	68	12	protein	protein	NOUN
biomedich-902	68	13	structures	structure	NOUN
biomedich-902	68	14	and	and	CCONJ
biomedich-902	68	15	are	be	AUX
biomedich-902	68	16	kept	keep	VERB
biomedich-902	68	17	in	in	ADP
biomedich-902	68	18	the	the	DET
biomedich-902	68	19	rcsb	rcsb	ADJ
biomedich-902	68	20	protein	protein	NOUN
biomedich-902	68	21	data	datum	NOUN
biomedich-902	68	22	library	library	NOUN
biomedich-902	68	23	.	.	PUNCT
biomedich-902	69	1	data	datum	NOUN
biomedich-902	69	2	from	from	ADP
biomedich-902	69	3	the	the	DET
biomedich-902	69	4	pubchem	pubchem	NOUN
biomedich-902	69	5	database	database	NOUN
biomedich-902	69	6	was	be	AUX
biomedich-902	69	7	used	use	VERB
biomedich-902	69	8	to	to	PART
biomedich-902	69	9	optimize	optimize	VERB
biomedich-902	69	10	the	the	DET
biomedich-902	69	11	inhibitors	inhibitor	NOUN
biomedich-902	69	12	'	'	PART
biomedich-902	69	13	structures	structure	NOUN
biomedich-902	69	14	using	use	VERB
biomedich-902	69	15	the	the	DET
biomedich-902	69	16	same	same	ADJ
biomedich-902	69	17	theoretical	theoretical	ADJ
biomedich-902	69	18	level	level	NOUN
biomedich-902	69	19	.	.	PUNCT
biomedich-902	70	1	for	for	ADP
biomedich-902	70	2	docking	dock	VERB
biomedich-902	70	3	studies	study	NOUN
biomedich-902	70	4	,	,	PUNCT
biomedich-902	70	5	these	these	DET
biomedich-902	70	6	optimized	optimize	VERB
biomedich-902	70	7	structures	structure	NOUN
biomedich-902	70	8	served	serve	VERB
biomedich-902	70	9	as	as	ADP
biomedich-902	70	10	ligands	ligand	NOUN
biomedich-902	70	11	.	.	PUNCT
biomedich-902	71	1	using	use	VERB
biomedich-902	71	2	the	the	DET
biomedich-902	71	3	same	same	ADJ
biomedich-902	71	4	docking	docking	NOUN
biomedich-902	71	5	procedure	procedure	NOUN
biomedich-902	71	6	that	that	PRON
biomedich-902	71	7	was	be	AUX
biomedich-902	71	8	utilized	utilize	VERB
biomedich-902	71	9	to	to	PART
biomedich-902	71	10	bind	bind	VERB
biomedich-902	71	11	the	the	DET
biomedich-902	71	12	protein	protein	NOUN
biomedich-902	71	13	and	and	CCONJ
biomedich-902	71	14	phytochemicals	phytochemical	NOUN
biomedich-902	71	15	in	in	ADP
biomedich-902	71	16	bitter	bitter	ADJ
biomedich-902	71	17	melon	melon	NOUN
biomedich-902	71	18	,	,	PUNCT
biomedich-902	71	19	the	the	DET
biomedich-902	71	20	inhibitor	inhibitor	NOUN
biomedich-902	71	21	was	be	AUX
biomedich-902	71	22	docked	dock	VERB
biomedich-902	71	23	to	to	ADP
biomedich-902	71	24	the	the	DET
biomedich-902	71	25	gsk-3	gsk-3	DET
biomedich-902	71	26	protein	protein	NOUN
biomedich-902	71	27	.	.	PUNCT
biomedich-902	72	1	autodock	autodock	NOUN
biomedich-902	72	2	tools	tool	NOUN
biomedich-902	72	3	1.5.6	1.5.6	NUM
biomedich-902	72	4	was	be	AUX
biomedich-902	72	5	used	use	VERB
biomedich-902	72	6	to	to	PART
biomedich-902	72	7	examine	examine	VERB
biomedich-902	72	8	the	the	DET
biomedich-902	72	9	docked	docked	ADJ
biomedich-902	72	10	conformation	conformation	NOUN
biomedich-902	72	11	's	's	PART
biomedich-902	72	12	binding	bind	VERB
biomedich-902	72	13	energies	energy	NOUN
biomedich-902	72	14	.	.	PUNCT
biomedich-902	73	1	admet	admet	PROPN
biomedich-902	73	2	study	study	PROPN
biomedich-902	73	3	protox	protox	PROPN
biomedich-902	73	4	-	-	PUNCT
biomedich-902	73	5	ii	ii	PROPN
biomedich-902	73	6	and	and	CCONJ
biomedich-902	73	7	the	the	DET
biomedich-902	73	8	pkcsm	pkcsm	NOUN
biomedich-902	73	9	web	web	NOUN
biomedich-902	73	10	server	server	NOUN
biomedich-902	73	11	were	be	AUX
biomedich-902	73	12	both	both	PRON
biomedich-902	73	13	used	use	VERB
biomedich-902	73	14	in	in	ADP
biomedich-902	73	15	this	this	DET
biomedich-902	73	16	investigation	investigation	NOUN
biomedich-902	73	17	to	to	PART
biomedich-902	73	18	forecast	forecast	VERB
biomedich-902	73	19	the	the	DET
biomedich-902	73	20	compounds	compound	NOUN
biomedich-902	73	21	'	'	PART
biomedich-902	73	22	admet	admet	PROPN
biomedich-902	73	23	profiles	profile	NOUN
biomedich-902	73	24	.	.	PUNCT
biomedich-902	74	1	while	while	SCONJ
biomedich-902	74	2	protox	protox	NOUN
biomedich-902	74	3	-	-	PUNCT
biomedich-902	74	4	ii	ii	NOUN
biomedich-902	74	5	delivers	deliver	VERB
biomedich-902	74	6	a	a	DET
biomedich-902	74	7	toxicity	toxicity	NOUN
biomedich-902	74	8	assessment	assessment	NOUN
biomedich-902	74	9	that	that	PRON
biomedich-902	74	10	includes	include	VERB
biomedich-902	74	11	potential	potential	ADJ
biomedich-902	74	12	side	side	NOUN
biomedich-902	74	13	effects	effect	NOUN
biomedich-902	74	14	and	and	CCONJ
biomedich-902	74	15	safety	safety	NOUN
biomedich-902	74	16	categories	category	NOUN
biomedich-902	74	17	,	,	PUNCT
biomedich-902	74	18	the	the	DET
biomedich-902	74	19	pkcsm	pkcsm	NOUN
biomedich-902	74	20	server	server	NOUN
biomedich-902	74	21	provides	provide	VERB
biomedich-902	74	22	comprehensive	comprehensive	ADJ
biomedich-902	74	23	pharmacokinetic	pharmacokinetic	ADJ
biomedich-902	74	24	information	information	NOUN
biomedich-902	74	25	.	.	PUNCT
biomedich-902	75	1	a	a	DET
biomedich-902	75	2	number	number	NOUN
biomedich-902	75	3	of	of	ADP
biomedich-902	75	4	phytochemical	phytochemical	ADJ
biomedich-902	75	5	toxicity	toxicity	NOUN
biomedich-902	75	6	metrics	metric	NOUN
biomedich-902	75	7	,	,	PUNCT
biomedich-902	75	8	such	such	ADJ
biomedich-902	75	9	as	as	ADP
biomedich-902	75	10	hepatotoxicity	hepatotoxicity	NOUN
biomedich-902	75	11	,	,	PUNCT
biomedich-902	75	12	carcinogenicity	carcinogenicity	NOUN
biomedich-902	75	13	,	,	PUNCT
biomedich-902	75	14	mutagenicity	mutagenicity	NOUN
biomedich-902	75	15	,	,	PUNCT
biomedich-902	75	16	cytotoxicity	cytotoxicity	NOUN
biomedich-902	75	17	,	,	PUNCT
biomedich-902	75	18	ld50	ld50	PROPN
biomedich-902	75	19	(	(	PUNCT
biomedich-902	75	20	mg	mg	PROPN
biomedich-902	75	21	/	/	SYM
biomedich-902	75	22	kg	kg	PROPN
biomedich-902	75	23	)	)	PUNCT
biomedich-902	75	24	,	,	PUNCT
biomedich-902	75	25	and	and	CCONJ
biomedich-902	75	26	toxicity	toxicity	NOUN
biomedich-902	75	27	class	class	NOUN
biomedich-902	75	28	,	,	PUNCT
biomedich-902	75	29	were	be	AUX
biomedich-902	75	30	obtained	obtain	VERB
biomedich-902	75	31	using	use	VERB
biomedich-902	75	32	the	the	DET
biomedich-902	75	33	protox	protox	NOUN
biomedich-902	75	34	-	-	PUNCT
biomedich-902	75	35	ii	ii	PROPN
biomedich-902	75	36	server	server	NOUN
biomedich-902	75	37	.	.	PUNCT
biomedich-902	76	1	data	datum	NOUN
biomedich-902	76	2	analysis	analysis	NOUN
biomedich-902	76	3	by	by	ADP
biomedich-902	76	4	choosing	choose	VERB
biomedich-902	76	5	the	the	DET
biomedich-902	76	6	lowest	low	ADJ
biomedich-902	76	7	binding	bind	VERB
biomedich-902	76	8	energy	energy	NOUN
biomedich-902	76	9	and	and	CCONJ
biomedich-902	76	10	matching	matching	NOUN
biomedich-902	76	11	inhibition	inhibition	NOUN
biomedich-902	76	12	constant	constant	ADJ
biomedich-902	76	13	(	(	PUNCT
biomedich-902	76	14	ki	ki	PROPN
biomedich-902	76	15	)	)	PUNCT
biomedich-902	76	16	from	from	ADP
biomedich-902	76	17	ten	ten	NUM
biomedich-902	76	18	trials	trial	NOUN
biomedich-902	76	19	per	per	ADP
biomedich-902	76	20	protein	protein	NOUN
biomedich-902	76	21	-	-	PUNCT
biomedich-902	76	22	ligand	ligand	NOUN
biomedich-902	76	23	pair	pair	NOUN
biomedich-902	76	24	,	,	PUNCT
biomedich-902	76	25	the	the	DET
biomedich-902	76	26	docking	docking	NOUN
biomedich-902	76	27	data	datum	NOUN
biomedich-902	76	28	were	be	AUX
biomedich-902	76	29	examined	examine	VERB
biomedich-902	76	30	.	.	PUNCT
biomedich-902	77	1	a	a	DET
biomedich-902	77	2	comparative	comparative	ADJ
biomedich-902	77	3	analysis	analysis	NOUN
biomedich-902	77	4	revealed	reveal	VERB
biomedich-902	77	5	that	that	SCONJ
biomedich-902	77	6	vicine	vicine	NOUN
biomedich-902	77	7	and	and	CCONJ
biomedich-902	77	8	charantin	charantin	NOUN
biomedich-902	77	9	interacted	interact	VERB
biomedich-902	77	10	more	more	ADV
biomedich-902	77	11	strongly	strongly	ADV
biomedich-902	77	12	with	with	ADP
biomedich-902	77	13	the	the	DET
biomedich-902	77	14	insulin	insulin	NOUN
biomedich-902	77	15	receptor	receptor	NOUN
biomedich-902	77	16	and	and	CCONJ
biomedich-902	77	17	gsk-3	gsk-3	PRON
biomedich-902	77	18	(	(	PUNCT
biomedich-902	77	19	including	include	VERB
biomedich-902	77	20	its	its	PRON
biomedich-902	77	21	a	a	PRON
biomedich-902	77	22	and	and	CCONJ
biomedich-902	77	23	b	b	NOUN
biomedich-902	77	24	variants	variant	NOUN
biomedich-902	77	25	)	)	PUNCT
biomedich-902	77	26	.	.	PUNCT
biomedich-902	78	1	plip	plip	PROPN
biomedich-902	78	2	and	and	CCONJ
biomedich-902	78	3	discovery	discovery	PROPN
biomedich-902	78	4	studio	studio	NOUN
biomedich-902	78	5	were	be	AUX
biomedich-902	78	6	utilized	utilize	VERB
biomedich-902	78	7	to	to	PART
biomedich-902	78	8	investigate	investigate	VERB
biomedich-902	78	9	protein	protein	NOUN
biomedich-902	78	10	-	-	PUNCT
biomedich-902	78	11	ligand	ligand	NOUN
biomedich-902	78	12	interactions	interaction	NOUN
biomedich-902	78	13	,	,	PUNCT
biomedich-902	78	14	and	and	CCONJ
biomedich-902	78	15	pymol	pymol	PROPN
biomedich-902	78	16	was	be	AUX
biomedich-902	78	17	employed	employ	VERB
biomedich-902	78	18	to	to	PART
biomedich-902	78	19	visualize	visualize	VERB
biomedich-902	78	20	the	the	DET
biomedich-902	78	21	structure	structure	NOUN
biomedich-902	78	22	.	.	PUNCT
biomedich-902	79	1	the	the	DET
biomedich-902	79	2	protox	protox	PROPN
biomedich-902	79	3	-	-	PUNCT
biomedich-902	79	4	ii	ii	PROPN
biomedich-902	79	5	web	web	NOUN
biomedich-902	79	6	server	server	NOUN
biomedich-902	79	7	was	be	AUX
biomedich-902	79	8	used	use	VERB
biomedich-902	79	9	to	to	PART
biomedich-902	79	10	estimate	estimate	VERB
biomedich-902	79	11	admet	admet	NOUN
biomedich-902	79	12	and	and	CCONJ
biomedich-902	79	13	toxicity	toxicity	NOUN
biomedich-902	79	14	profiles	profile	NOUN
biomedich-902	79	15	in	in	ADP
biomedich-902	79	16	order	order	NOUN
biomedich-902	79	17	to	to	PART
biomedich-902	79	18	evaluate	evaluate	VERB
biomedich-902	79	19	the	the	DET
biomedich-902	79	20	compounds	compound	NOUN
biomedich-902	79	21	'	'	PART
biomedich-902	79	22	safety	safety	NOUN
biomedich-902	79	23	and	and	CCONJ
biomedich-902	79	24	drug	drug	NOUN
biomedich-902	79	25	-	-	PUNCT
biomedich-902	79	26	likeness	likeness	NOUN
biomedich-902	79	27	.	.	PUNCT
biomedich-902	80	1	results	result	NOUN
biomedich-902	80	2	and	and	CCONJ
biomedich-902	80	3	discussion	discussion	NOUN
biomedich-902	80	4	docking	docking	NOUN
biomedich-902	80	5	results	result	NOUN
biomedich-902	80	6	and	and	CCONJ
biomedich-902	80	7	optimized	optimize	VERB
biomedich-902	80	8	results	result	NOUN
biomedich-902	80	9	table	table	NOUN
biomedich-902	80	10	1	1	NUM
biomedich-902	80	11	.	.	PUNCT
biomedich-902	81	1	the	the	DET
biomedich-902	81	2	results	result	NOUN
biomedich-902	81	3	of	of	ADP
biomedich-902	81	4	optimization	optimization	NOUN
biomedich-902	81	5	and	and	CCONJ
biomedich-902	81	6	docking	docking	NOUN
biomedich-902	81	7	process	process	NOUN
biomedich-902	81	8	.	.	PUNCT
biomedich-902	82	1	name	name	NOUN
biomedich-902	82	2	of	of	ADP
biomedich-902	82	3	the	the	DET
biomedich-902	82	4	phytochemical	phytochemical	ADJ
biomedich-902	82	5	optimized	optimize	VERB
biomedich-902	82	6	energy	energy	NOUN
biomedich-902	82	7	(	(	PUNCT
biomedich-902	82	8	x	x	SYM
biomedich-902	82	9	104	104	NUM
biomedich-902	82	10	kcal	kcal	PROPN
biomedich-902	82	11	/mol	/mol	PROPN
biomedich-902	82	12	)	)	PUNCT
biomedich-902	82	13	lowest	low	ADJ
biomedich-902	82	14	binding	bind	VERB
biomedich-902	82	15	energy	energy	NOUN
biomedich-902	82	16	with	with	ADP
biomedich-902	82	17	insulin	insulin	NOUN
biomedich-902	82	18	receptor(kcal	receptor(kcal	PROPN
biomedich-902	82	19	/	/	SYM
biomedich-902	82	20	mol	mol	NOUN
biomedich-902	82	21	)	)	PUNCT
biomedich-902	82	22	lowest	low	ADJ
biomedich-902	82	23	binding	bind	VERB
biomedich-902	82	24	energy	energy	NOUN
biomedich-902	82	25	with	with	ADP
biomedich-902	82	26	gsk-3	gsk-3	PUNCT
biomedich-902	82	27	protein(kcal	protein(kcal	PROPN
biomedich-902	82	28	/	/	SYM
biomedich-902	82	29	mol	mol	NOUN
biomedich-902	82	30	)	)	PUNCT
biomedich-902	82	31	charantin	charantin	NOUN
biomedich-902	82	32	-114.3271	-114.3271	NUM
biomedich-902	82	33	-8.76	-8.76	NUM
biomedich-902	82	34	-8.49	-8.49	NUM
biomedich-902	82	35	vicine	vicine	VERB
biomedich-902	82	36	-71.3229	-71.3229	PUNCT
biomedich-902	82	37	-6.02	-6.02	NUM
biomedich-902	82	38	-6.71	-6.71	NOUN
biomedich-902	82	39	according	accord	VERB
biomedich-902	82	40	to	to	ADP
biomedich-902	82	41	the	the	DET
biomedich-902	82	42	results	result	NOUN
biomedich-902	82	43	of	of	ADP
biomedich-902	82	44	the	the	DET
biomedich-902	82	45	molecular	molecular	ADJ
biomedich-902	82	46	docking	docking	NOUN
biomedich-902	82	47	investigation	investigation	NOUN
biomedich-902	82	48	,	,	PUNCT
biomedich-902	82	49	charantin	charantin	PROPN
biomedich-902	82	50	has	have	VERB
biomedich-902	82	51	a	a	DET
biomedich-902	82	52	substantially	substantially	ADV
biomedich-902	82	53	greater	great	ADJ
biomedich-902	82	54	binding	bind	VERB
biomedich-902	82	55	affinity	affinity	NOUN
biomedich-902	82	56	than	than	ADP
biomedich-902	82	57	vicine	vicine	NOUN
biomedich-902	82	58	for	for	ADP
biomedich-902	82	59	the	the	DET
biomedich-902	82	60	gsk-3	gsk-3	NOUN
biomedich-902	82	61	protein	protein	NOUN
biomedich-902	82	62	and	and	CCONJ
biomedich-902	82	63	the	the	DET
biomedich-902	82	64	insulin	insulin	NOUN
biomedich-902	82	65	receptor	receptor	NOUN
biomedich-902	82	66	.	.	PUNCT
biomedich-902	83	1	with	with	ADP
biomedich-902	83	2	the	the	DET
biomedich-902	83	3	lowest	low	ADJ
biomedich-902	83	4	binding	bind	VERB
biomedich-902	83	5	energies	energy	NOUN
biomedich-902	83	6	of	of	ADP
biomedich-902	83	7	https://www.rcsb.org/	https://www.rcsb.org/	ADJ
biomedich-902	83	8	1108	1108	NUM
biomedich-902	83	9	biology	biology	NOUN
biomedich-902	83	10	,	,	PUNCT
biomedich-902	83	11	medicine	medicine	NOUN
biomedich-902	83	12	,	,	PUNCT
biomedich-902	83	13	&	&	CCONJ
biomedich-902	83	14	natural	natural	ADJ
biomedich-902	83	15	product	product	NOUN
biomedich-902	83	16	chemistry	chemistry	NOUN
biomedich-902	83	17	14	14	NUM
biomedich-902	83	18	(	(	PUNCT
biomedich-902	83	19	2	2	NUM
biomedich-902	83	20	)	)	PUNCT
biomedich-902	83	21	,	,	PUNCT
biomedich-902	83	22	2025	2025	NUM
biomedich-902	83	23	:	:	PUNCT
biomedich-902	83	24	1105	1105	NUM
biomedich-902	83	25	-	-	SYM
biomedich-902	83	26	1110	1110	NUM
biomedich-902	83	27	-8.76	-8.76	NUM
biomedich-902	83	28	kcal	kcal	PROPN
biomedich-902	83	29	/	/	SYM
biomedich-902	83	30	mol	mol	NOUN
biomedich-902	83	31	for	for	ADP
biomedich-902	83	32	the	the	DET
biomedich-902	83	33	insulin	insulin	NOUN
biomedich-902	83	34	receptor	receptor	NOUN
biomedich-902	83	35	and	and	CCONJ
biomedich-902	83	36	-8.49	-8.49	NOUN
biomedich-902	83	37	kcal	kcal	NOUN
biomedich-902	83	38	/	/	SYM
biomedich-902	83	39	mol	mol	NOUN
biomedich-902	83	40	for	for	ADP
biomedich-902	83	41	gsk-3	gsk-3	NOUN
biomedich-902	83	42	,	,	PUNCT
biomedich-902	83	43	charantin	charantin	PROPN
biomedich-902	83	44	demonstrated	demonstrate	VERB
biomedich-902	83	45	a	a	DET
biomedich-902	83	46	robust	robust	ADJ
biomedich-902	83	47	and	and	CCONJ
biomedich-902	83	48	consistent	consistent	ADJ
biomedich-902	83	49	interaction	interaction	NOUN
biomedich-902	83	50	with	with	ADP
biomedich-902	83	51	these	these	DET
biomedich-902	83	52	important	important	ADJ
biomedich-902	83	53	targets	target	NOUN
biomedich-902	83	54	that	that	PRON
biomedich-902	83	55	are	be	AUX
biomedich-902	83	56	involved	involve	VERB
biomedich-902	83	57	in	in	ADP
biomedich-902	83	58	insulin	insulin	NOUN
biomedich-902	83	59	signaling	signaling	NOUN
biomedich-902	83	60	and	and	CCONJ
biomedich-902	83	61	glucose	glucose	NOUN
biomedich-902	83	62	regulation	regulation	NOUN
biomedich-902	83	63	.	.	PUNCT
biomedich-902	84	1	vicine	vicine	PROPN
biomedich-902	84	2	,	,	PUNCT
biomedich-902	84	3	on	on	ADP
biomedich-902	84	4	the	the	DET
biomedich-902	84	5	other	other	ADJ
biomedich-902	84	6	hand	hand	NOUN
biomedich-902	84	7	,	,	PUNCT
biomedich-902	84	8	had	have	VERB
biomedich-902	84	9	binding	bind	VERB
biomedich-902	84	10	energies	energy	NOUN
biomedich-902	84	11	of	of	ADP
biomedich-902	84	12	-6.02	-6.02	NUM
biomedich-902	84	13	kcal	kcal	NOUN
biomedich-902	84	14	/	/	SYM
biomedich-902	84	15	mol	mol	PROPN
biomedich-902	84	16	and	and	CCONJ
biomedich-902	84	17	-6.71	-6.71	VERB
biomedich-902	84	18	kcal	kcal	PROPN
biomedich-902	84	19	/	/	SYM
biomedich-902	84	20	mol	mol	NOUN
biomedich-902	84	21	,	,	PUNCT
biomedich-902	84	22	respectively	respectively	ADV
biomedich-902	84	23	,	,	PUNCT
biomedich-902	84	24	which	which	PRON
biomedich-902	84	25	were	be	AUX
biomedich-902	84	26	significantly	significantly	ADV
biomedich-902	84	27	lower	low	ADJ
biomedich-902	84	28	.	.	PUNCT
biomedich-902	85	1	charantin	charantin	PROPN
biomedich-902	85	2	's	's	PART
biomedich-902	85	3	structural	structural	ADJ
biomedich-902	85	4	stability	stability	NOUN
biomedich-902	85	5	is	be	AUX
biomedich-902	85	6	further	far	ADV
biomedich-902	85	7	supported	support	VERB
biomedich-902	85	8	by	by	ADP
biomedich-902	85	9	its	its	PRON
biomedich-902	85	10	optimized	optimize	VERB
biomedich-902	85	11	energy	energy	NOUN
biomedich-902	85	12	(	(	PUNCT
biomedich-902	85	13	-114.3271	-114.3271	NUM
biomedich-902	85	14	x	x	SYM
biomedich-902	85	15	104	104	NUM
biomedich-902	85	16	kcal	kcal	NOUN
biomedich-902	85	17	/	/	SYM
biomedich-902	85	18	mol	mol	NOUN
biomedich-902	85	19	)	)	PUNCT
biomedich-902	85	20	,	,	PUNCT
biomedich-902	85	21	which	which	PRON
biomedich-902	85	22	could	could	AUX
biomedich-902	85	23	be	be	AUX
biomedich-902	85	24	a	a	DET
biomedich-902	85	25	factor	factor	NOUN
biomedich-902	85	26	in	in	ADP
biomedich-902	85	27	its	its	PRON
biomedich-902	85	28	enhanced	enhanced	ADJ
biomedich-902	85	29	inhibitory	inhibitory	ADJ
biomedich-902	85	30	capability	capability	NOUN
biomedich-902	85	31	.	.	PUNCT
biomedich-902	86	1	these	these	DET
biomedich-902	86	2	findings	finding	NOUN
biomedich-902	86	3	demonstrate	demonstrate	VERB
biomedich-902	86	4	charantin	charantin	PROPN
biomedich-902	86	5	's	's	PART
biomedich-902	86	6	potential	potential	NOUN
biomedich-902	86	7	as	as	ADP
biomedich-902	86	8	a	a	DET
biomedich-902	86	9	multi	multi	ADJ
biomedich-902	86	10	-	-	ADJ
biomedich-902	86	11	target	target	ADJ
biomedich-902	86	12	antidiabetic	antidiabetic	ADJ
biomedich-902	86	13	drug	drug	NOUN
biomedich-902	86	14	that	that	PRON
biomedich-902	86	15	can	can	AUX
biomedich-902	86	16	alter	alter	VERB
biomedich-902	86	17	gsk-3	gsk-3	ADP
biomedich-902	86	18	function	function	NOUN
biomedich-902	86	19	and	and	CCONJ
biomedich-902	86	20	insulin	insulin	NOUN
biomedich-902	86	21	receptor	receptor	NOUN
biomedich-902	86	22	activation	activation	NOUN
biomedich-902	86	23	,	,	PUNCT
biomedich-902	86	24	two	two	NUM
biomedich-902	86	25	essential	essential	ADJ
biomedich-902	86	26	pathways	pathway	NOUN
biomedich-902	86	27	for	for	ADP
biomedich-902	86	28	blood	blood	NOUN
biomedich-902	86	29	sugar	sugar	NOUN
biomedich-902	86	30	regulation	regulation	NOUN
biomedich-902	86	31	.	.	PUNCT
biomedich-902	87	1	charantin	charantin	PROPN
biomedich-902	87	2	's	's	PART
biomedich-902	87	3	ability	ability	NOUN
biomedich-902	87	4	to	to	PART
biomedich-902	87	5	improve	improve	VERB
biomedich-902	87	6	insulin	insulin	NOUN
biomedich-902	87	7	sensitivity	sensitivity	NOUN
biomedich-902	87	8	and	and	CCONJ
biomedich-902	87	9	glucose	glucose	NOUN
biomedich-902	87	10	homeostasis	homeostasis	NOUN
biomedich-902	87	11	may	may	AUX
biomedich-902	87	12	be	be	AUX
biomedich-902	87	13	supported	support	VERB
biomedich-902	87	14	by	by	ADP
biomedich-902	87	15	its	its	PRON
biomedich-902	87	16	stronger	strong	ADJ
biomedich-902	87	17	interactions	interaction	NOUN
biomedich-902	87	18	,	,	PUNCT
biomedich-902	87	19	which	which	PRON
biomedich-902	87	20	also	also	ADV
biomedich-902	87	21	support	support	VERB
biomedich-902	87	22	its	its	PRON
biomedich-902	87	23	potential	potential	NOUN
biomedich-902	87	24	for	for	ADP
biomedich-902	87	25	development	development	NOUN
biomedich-902	87	26	into	into	ADP
biomedich-902	87	27	safer	safe	ADJ
biomedich-902	87	28	,	,	PUNCT
biomedich-902	87	29	natural	natural	ADJ
biomedich-902	87	30	pharmaceutical	pharmaceutical	ADJ
biomedich-902	87	31	alternatives	alternative	NOUN
biomedich-902	87	32	for	for	ADP
biomedich-902	87	33	the	the	DET
biomedich-902	87	34	treatment	treatment	NOUN
biomedich-902	87	35	of	of	ADP
biomedich-902	87	36	diabetes	diabetes	NOUN
biomedich-902	87	37	.	.	PUNCT
biomedich-902	88	1	docking	dock	VERB
biomedich-902	88	2	interactions	interaction	NOUN
biomedich-902	88	3	of	of	ADP
biomedich-902	88	4	charantin	charantin	ADJ
biomedich-902	88	5	figure	figure	NOUN
biomedich-902	88	6	3	3	NUM
biomedich-902	88	7	.	.	PUNCT
biomedich-902	88	8	docking	dock	VERB
biomedich-902	88	9	analysis	analysis	NOUN
biomedich-902	88	10	of	of	ADP
biomedich-902	88	11	charantin	charantin	PROPN
biomedich-902	88	12	a	a	PRON
biomedich-902	88	13	)	)	PUNCT
biomedich-902	88	14	interaction	interaction	NOUN
biomedich-902	88	15	surface	surface	NOUN
biomedich-902	88	16	of	of	ADP
biomedich-902	88	17	insulincharantin	insulincharantin	ADJ
biomedich-902	88	18	complex	complex	PROPN
biomedich-902	88	19	b	b	PROPN
biomedich-902	88	20	)	)	PUNCT
biomedich-902	88	21	3d	3d	NOUN
biomedich-902	88	22	representation	representation	NOUN
biomedich-902	88	23	of	of	ADP
biomedich-902	88	24	insulin	insulin	NOUN
biomedich-902	88	25	-	-	PUNCT
biomedich-902	88	26	charantin	charantin	NOUN
biomedich-902	88	27	binding	bind	VERB
biomedich-902	88	28	pocket	pocket	NOUN
biomedich-902	88	29	c	c	NOUN
biomedich-902	88	30	)	)	PUNCT
biomedich-902	88	31	interaction	interaction	NOUN
biomedich-902	88	32	surface	surface	NOUN
biomedich-902	88	33	of	of	ADP
biomedich-902	88	34	gsk-3	gsk-3	PUNCT
biomedich-902	88	35	protein	protein	NOUN
biomedich-902	88	36	-	-	PUNCT
biomedich-902	88	37	charantin	charantin	NOUN
biomedich-902	88	38	complex	complex	ADJ
biomedich-902	88	39	d	d	NOUN
biomedich-902	88	40	)	)	PUNCT
biomedich-902	88	41	3d	3d	NOUN
biomedich-902	88	42	representation	representation	NOUN
biomedich-902	88	43	of	of	ADP
biomedich-902	88	44	gsk-3	gsk-3	PUNCT
biomedich-902	88	45	protein	protein	NOUN
biomedich-902	88	46	-	-	PUNCT
biomedich-902	88	47	charantin	charantin	NOUN
biomedich-902	88	48	binding	bind	VERB
biomedich-902	88	49	pocket	pocket	NOUN
biomedich-902	88	50	.	.	PUNCT
biomedich-902	89	1	strong	strong	ADJ
biomedich-902	89	2	polar	polar	ADJ
biomedich-902	89	3	interactions	interaction	NOUN
biomedich-902	89	4	that	that	PRON
biomedich-902	89	5	support	support	VERB
biomedich-902	89	6	the	the	DET
biomedich-902	89	7	high	high	ADJ
biomedich-902	89	8	binding	bind	VERB
biomedich-902	89	9	affinity	affinity	NOUN
biomedich-902	89	10	and	and	CCONJ
biomedich-902	89	11	stable	stable	ADJ
biomedich-902	89	12	complex	complex	ADJ
biomedich-902	89	13	formation	formation	NOUN
biomedich-902	89	14	are	be	AUX
biomedich-902	89	15	indicated	indicate	VERB
biomedich-902	89	16	by	by	ADP
biomedich-902	89	17	the	the	DET
biomedich-902	89	18	interaction	interaction	NOUN
biomedich-902	89	19	analysis	analysis	NOUN
biomedich-902	89	20	of	of	ADP
biomedich-902	89	21	charantin	charantin	NOUN
biomedich-902	89	22	with	with	ADP
biomedich-902	89	23	the	the	DET
biomedich-902	89	24	gsk-3	gsk-3	PUNCT
biomedich-902	89	25	protein	protein	NOUN
biomedich-902	89	26	(	(	PUNCT
biomedich-902	89	27	as	as	SCONJ
biomedich-902	89	28	shown	show	VERB
biomedich-902	89	29	in	in	ADP
biomedich-902	89	30	figure	figure	NOUN
biomedich-902	89	31	3	3	NUM
biomedich-902	89	32	)	)	PUNCT
biomedich-902	89	33	,	,	PUNCT
biomedich-902	89	34	which	which	PRON
biomedich-902	89	35	mostly	mostly	ADV
biomedich-902	89	36	shows	show	VERB
biomedich-902	89	37	conventional	conventional	ADJ
biomedich-902	89	38	hydrogen	hydrogen	NOUN
biomedich-902	89	39	bonds	bond	NOUN
biomedich-902	89	40	and	and	CCONJ
biomedich-902	89	41	carbon	carbon	NOUN
biomedich-902	89	42	hydrogen	hydrogen	NOUN
biomedich-902	89	43	bonds	bond	NOUN
biomedich-902	89	44	.	.	PUNCT
biomedich-902	90	1	these	these	DET
biomedich-902	90	2	hydrogen	hydrogen	NOUN
biomedich-902	90	3	bonds	bond	NOUN
biomedich-902	90	4	are	be	AUX
biomedich-902	90	5	necessary	necessary	ADJ
biomedich-902	90	6	for	for	ADP
biomedich-902	90	7	precisely	precisely	ADV
biomedich-902	90	8	locating	locate	VERB
biomedich-902	90	9	charantin	charantin	NOUN
biomedich-902	90	10	in	in	ADP
biomedich-902	90	11	the	the	DET
biomedich-902	90	12	active	active	ADJ
biomedich-902	90	13	site	site	NOUN
biomedich-902	90	14	,	,	PUNCT
biomedich-902	90	15	which	which	PRON
biomedich-902	90	16	may	may	AUX
biomedich-902	90	17	prevent	prevent	VERB
biomedich-902	90	18	gsk-3	gsk-3	NOUN
biomedich-902	90	19	's	's	PART
biomedich-902	90	20	kinase	kinase	NOUN
biomedich-902	90	21	activity	activity	NOUN
biomedich-902	90	22	from	from	ADP
biomedich-902	90	23	regulating	regulate	VERB
biomedich-902	90	24	glucose	glucose	NOUN
biomedich-902	90	25	metabolism	metabolism	NOUN
biomedich-902	90	26	.	.	PUNCT
biomedich-902	91	1	charantin	charantin	PROPN
biomedich-902	91	2	's	's	PART
biomedich-902	91	3	interaction	interaction	NOUN
biomedich-902	91	4	with	with	ADP
biomedich-902	91	5	the	the	DET
biomedich-902	91	6	insulin	insulin	NOUN
biomedich-902	91	7	receptor	receptor	NOUN
biomedich-902	91	8	(	(	PUNCT
biomedich-902	91	9	as	as	SCONJ
biomedich-902	91	10	shown	show	VERB
biomedich-902	91	11	in	in	ADP
biomedich-902	91	12	figure	figure	NOUN
biomedich-902	91	13	3	3	NUM
biomedich-902	91	14	)	)	PUNCT
biomedich-902	91	15	,	,	PUNCT
biomedich-902	91	16	on	on	ADP
biomedich-902	91	17	the	the	DET
biomedich-902	91	18	other	other	ADJ
biomedich-902	91	19	hand	hand	NOUN
biomedich-902	91	20	,	,	PUNCT
biomedich-902	91	21	exhibits	exhibit	VERB
biomedich-902	91	22	a	a	DET
biomedich-902	91	23	wider	wide	ADJ
biomedich-902	91	24	variety	variety	NOUN
biomedich-902	91	25	of	of	ADP
biomedich-902	91	26	non	non	ADJ
biomedich-902	91	27	-	-	ADJ
biomedich-902	91	28	covalent	covalent	ADJ
biomedich-902	91	29	interactions	interaction	NOUN
biomedich-902	91	30	,	,	PUNCT
biomedich-902	91	31	such	such	ADJ
biomedich-902	91	32	as	as	ADP
biomedich-902	91	33	alkyl	alkyl	ADJ
biomedich-902	91	34	,	,	PUNCT
biomedich-902	91	35	pi	pi	NOUN
biomedich-902	91	36	-	-	PUNCT
biomedich-902	91	37	alkyl	alkyl	ADJ
biomedich-902	91	38	,	,	PUNCT
biomedich-902	91	39	and	and	CCONJ
biomedich-902	91	40	van	van	PROPN
biomedich-902	91	41	der	der	NOUN
biomedich-902	91	42	waals	waal	NOUN
biomedich-902	91	43	forces	force	NOUN
biomedich-902	91	44	.	.	PUNCT
biomedich-902	92	1	by	by	ADP
biomedich-902	92	2	enhancing	enhance	VERB
biomedich-902	92	3	the	the	DET
biomedich-902	92	4	molecular	molecular	ADJ
biomedich-902	92	5	fit	fit	NOUN
biomedich-902	92	6	and	and	CCONJ
biomedich-902	92	7	balancing	balance	VERB
biomedich-902	92	8	the	the	DET
biomedich-902	92	9	polar	polar	ADJ
biomedich-902	92	10	interactions	interaction	NOUN
biomedich-902	92	11	at	at	ADP
biomedich-902	92	12	the	the	DET
biomedich-902	92	13	binding	bind	VERB
biomedich-902	92	14	site	site	NOUN
biomedich-902	92	15	,	,	PUNCT
biomedich-902	92	16	these	these	DET
biomedich-902	92	17	hydrophobic	hydrophobic	NOUN
biomedich-902	92	18	contacts	contact	NOUN
biomedich-902	92	19	improve	improve	VERB
biomedich-902	92	20	the	the	DET
biomedich-902	92	21	binding	bind	VERB
biomedich-902	92	22	stability	stability	NOUN
biomedich-902	92	23	.	.	PUNCT
biomedich-902	93	1	charantin	charantin	PROPN
biomedich-902	93	2	effectively	effectively	ADV
biomedich-902	93	3	occupies	occupy	VERB
biomedich-902	93	4	hydrophobic	hydrophobic	NOUN
biomedich-902	93	5	pockets	pocket	NOUN
biomedich-902	93	6	on	on	ADP
biomedich-902	93	7	the	the	DET
biomedich-902	93	8	insulin	insulin	NOUN
biomedich-902	93	9	receptor	receptor	NOUN
biomedich-902	93	10	,	,	PUNCT
biomedich-902	93	11	which	which	PRON
biomedich-902	93	12	may	may	AUX
biomedich-902	93	13	be	be	AUX
biomedich-902	93	14	essential	essential	ADJ
biomedich-902	93	15	for	for	ADP
biomedich-902	93	16	regulating	regulate	VERB
biomedich-902	93	17	insulin	insulin	NOUN
biomedich-902	93	18	signaling	signal	VERB
biomedich-902	93	19	and	and	CCONJ
biomedich-902	93	20	receptor	receptor	NOUN
biomedich-902	93	21	activation	activation	NOUN
biomedich-902	93	22	,	,	PUNCT
biomedich-902	93	23	according	accord	VERB
biomedich-902	93	24	to	to	ADP
biomedich-902	93	25	the	the	DET
biomedich-902	93	26	existence	existence	NOUN
biomedich-902	93	27	of	of	ADP
biomedich-902	93	28	alkyl	alkyl	NOUN
biomedich-902	93	29	and	and	CCONJ
biomedich-902	93	30	pi	pi	NOUN
biomedich-902	93	31	-	-	PUNCT
biomedich-902	93	32	alkyl	alkyl	ADJ
biomedich-902	93	33	interactions	interaction	NOUN
biomedich-902	93	34	.	.	PUNCT
biomedich-902	94	1	all	all	DET
biomedich-902	94	2	things	thing	NOUN
biomedich-902	94	3	considered	consider	VERB
biomedich-902	94	4	,	,	PUNCT
biomedich-902	94	5	charantin	charantin	PROPN
biomedich-902	94	6	's	's	PART
biomedich-902	94	7	capacity	capacity	NOUN
biomedich-902	94	8	to	to	PART
biomedich-902	94	9	efficiently	efficiently	ADV
biomedich-902	94	10	bind	bind	VERB
biomedich-902	94	11	and	and	CCONJ
biomedich-902	94	12	modify	modify	VERB
biomedich-902	94	13	a	a	DET
biomedich-902	94	14	variety	variety	NOUN
biomedich-902	94	15	of	of	ADP
biomedich-902	94	16	protein	protein	NOUN
biomedich-902	94	17	targets	target	NOUN
biomedich-902	94	18	is	be	AUX
biomedich-902	94	19	demonstrated	demonstrate	VERB
biomedich-902	94	20	by	by	ADP
biomedich-902	94	21	its	its	PRON
biomedich-902	94	22	potent	potent	ADJ
biomedich-902	94	23	hydrogen	hydrogen	NOUN
biomedich-902	94	24	bonding	bonding	NOUN
biomedich-902	94	25	with	with	ADP
biomedich-902	94	26	gsk-3	gsk-3	PUNCT
biomedich-902	94	27	and	and	CCONJ
biomedich-902	94	28	its	its	PRON
biomedich-902	94	29	adaptable	adaptable	ADJ
biomedich-902	94	30	hydrophobic	hydrophobic	NOUN
biomedich-902	94	31	interactions	interaction	NOUN
biomedich-902	94	32	with	with	ADP
biomedich-902	94	33	the	the	DET
biomedich-902	94	34	insulin	insulin	NOUN
biomedich-902	94	35	receptor	receptor	NOUN
biomedich-902	94	36	.	.	PUNCT
biomedich-902	95	1	its	its	PRON
biomedich-902	95	2	potential	potential	NOUN
biomedich-902	95	3	as	as	ADP
biomedich-902	95	4	an	an	DET
biomedich-902	95	5	effective	effective	ADJ
biomedich-902	95	6	anti	anti	ADJ
biomedich-902	95	7	-	-	ADJ
biomedich-902	95	8	diabetic	diabetic	ADJ
biomedich-902	95	9	agent	agent	NOUN
biomedich-902	95	10	that	that	PRON
biomedich-902	95	11	works	work	VERB
biomedich-902	95	12	through	through	ADP
biomedich-902	95	13	complementary	complementary	ADJ
biomedich-902	95	14	mechanisms	mechanism	NOUN
biomedich-902	95	15	of	of	ADP
biomedich-902	95	16	gsk-3	gsk-3	NOUN
biomedich-902	95	17	inhibition	inhibition	NOUN
biomedich-902	95	18	and	and	CCONJ
biomedich-902	95	19	insulin	insulin	NOUN
biomedich-902	95	20	receptor	receptor	NOUN
biomedich-902	95	21	activation	activation	NOUN
biomedich-902	95	22	is	be	AUX
biomedich-902	95	23	supported	support	VERB
biomedich-902	95	24	by	by	ADP
biomedich-902	95	25	this	this	DET
biomedich-902	95	26	complex	complex	ADJ
biomedich-902	95	27	binding	bind	VERB
biomedich-902	95	28	profile	profile	NOUN
biomedich-902	95	29	.	.	PUNCT
biomedich-902	96	1	docking	dock	VERB
biomedich-902	96	2	interactions	interaction	NOUN
biomedich-902	96	3	of	of	ADP
biomedich-902	96	4	vicine	vicine	ADJ
biomedich-902	96	5	figure	figure	NOUN
biomedich-902	96	6	3	3	NUM
biomedich-902	96	7	.	.	PUNCT
biomedich-902	96	8	docking	dock	VERB
biomedich-902	96	9	analysis	analysis	NOUN
biomedich-902	96	10	of	of	ADP
biomedich-902	96	11	vicine	vicine	ADJ
biomedich-902	96	12	a	a	PRON
biomedich-902	96	13	)	)	PUNCT
biomedich-902	96	14	interaction	interaction	NOUN
biomedich-902	96	15	surface	surface	NOUN
biomedich-902	96	16	of	of	ADP
biomedich-902	96	17	gsk-3	gsk-3	PUNCT
biomedich-902	96	18	protein	protein	NOUN
biomedich-902	96	19	-	-	PUNCT
biomedich-902	96	20	vicine	vicine	NOUN
biomedich-902	96	21	complex	complex	ADJ
biomedich-902	96	22	b	b	NOUN
biomedich-902	96	23	)	)	PUNCT
biomedich-902	96	24	3d	3d	NOUN
biomedich-902	96	25	representation	representation	NOUN
biomedich-902	96	26	of	of	ADP
biomedich-902	96	27	gsk-3	gsk-3	PUNCT
biomedich-902	96	28	protein	protein	NOUN
biomedich-902	96	29	-	-	PUNCT
biomedich-902	96	30	vicine	vicine	ADJ
biomedich-902	96	31	binding	bind	VERB
biomedich-902	96	32	pocket	pocket	NOUN
biomedich-902	96	33	c	c	NOUN
biomedich-902	96	34	)	)	PUNCT
biomedich-902	96	35	interaction	interaction	NOUN
biomedich-902	96	36	surface	surface	NOUN
biomedich-902	96	37	of	of	ADP
biomedich-902	96	38	insulin	insulin	NOUN
biomedich-902	96	39	-	-	PUNCT
biomedich-902	96	40	vicine	vicine	NOUN
biomedich-902	96	41	complex	complex	ADJ
biomedich-902	96	42	d	d	NOUN
biomedich-902	96	43	)	)	PUNCT
biomedich-902	96	44	3d	3d	NOUN
biomedich-902	96	45	representation	representation	NOUN
biomedich-902	96	46	of	of	ADP
biomedich-902	96	47	insulin	insulin	NOUN
biomedich-902	96	48	-	-	PUNCT
biomedich-902	96	49	vicine	vicine	ADJ
biomedich-902	96	50	binding	bind	VERB
biomedich-902	96	51	pocket	pocket	NOUN
biomedich-902	96	52	.	.	PUNCT
biomedich-902	97	1	vicine	vicine	NOUN
biomedich-902	97	2	and	and	CCONJ
biomedich-902	97	3	insulin	insulin	NOUN
biomedich-902	97	4	interact	interact	NOUN
biomedich-902	97	5	via	via	ADP
biomedich-902	97	6	a	a	DET
biomedich-902	97	7	variety	variety	NOUN
biomedich-902	97	8	of	of	ADP
biomedich-902	97	9	noncovalent	noncovalent	ADJ
biomedich-902	97	10	bonding	bonding	NOUN
biomedich-902	97	11	mechanisms	mechanism	NOUN
biomedich-902	97	12	,	,	PUNCT
biomedich-902	97	13	such	such	ADJ
biomedich-902	97	14	as	as	ADP
biomedich-902	97	15	pi	pi	NOUN
biomedich-902	97	16	-	-	PUNCT
biomedich-902	97	17	anion	anion	NOUN
biomedich-902	97	18	interactions	interaction	NOUN
biomedich-902	97	19	,	,	PUNCT
biomedich-902	97	20	van	van	PROPN
biomedich-902	97	21	der	der	NOUN
biomedich-902	97	22	waals	waal	NOUN
biomedich-902	97	23	forces	force	NOUN
biomedich-902	97	24	,	,	PUNCT
biomedich-902	97	25	and	and	CCONJ
biomedich-902	97	26	traditional	traditional	ADJ
biomedich-902	97	27	hydrogen	hydrogen	NOUN
biomedich-902	97	28	bonds	bond	NOUN
biomedich-902	97	29	.	.	PUNCT
biomedich-902	98	1	by	by	ADP
biomedich-902	98	2	promoting	promote	VERB
biomedich-902	98	3	intimate	intimate	ADJ
biomedich-902	98	4	contact	contact	NOUN
biomedich-902	98	5	and	and	CCONJ
biomedich-902	98	6	complementarity	complementarity	NOUN
biomedich-902	98	7	between	between	ADP
biomedich-902	98	8	vicine	vicine	ADJ
biomedich-902	98	9	and	and	CCONJ
biomedich-902	98	10	insulin	insulin	NOUN
biomedich-902	98	11	molecules	molecule	NOUN
biomedich-902	98	12	,	,	PUNCT
biomedich-902	98	13	these	these	DET
biomedich-902	98	14	interactions	interaction	NOUN
biomedich-902	98	15	aid	aid	NOUN
biomedich-902	98	16	in	in	ADP
biomedich-902	98	17	the	the	DET
biomedich-902	98	18	stabilization	stabilization	NOUN
biomedich-902	98	19	of	of	ADP
biomedich-902	98	20	the	the	DET
biomedich-902	98	21	insulin	insulin	NOUN
biomedich-902	98	22	structure	structure	NOUN
biomedich-902	98	23	.	.	PUNCT
biomedich-902	99	1	tight	tight	ADJ
biomedich-902	99	2	binding	bind	VERB
biomedich-902	99	3	is	be	AUX
biomedich-902	99	4	ensured	ensure	VERB
biomedich-902	99	5	by	by	ADP
biomedich-902	99	6	hydrogen	hydrogen	NOUN
biomedich-902	99	7	bonds	bond	NOUN
biomedich-902	99	8	and	and	CCONJ
biomedich-902	99	9	van	van	PROPN
biomedich-902	99	10	der	der	NOUN
biomedich-902	99	11	waals	waal	NOUN
biomedich-902	99	12	forces	force	NOUN
biomedich-902	99	13	,	,	PUNCT
biomedich-902	99	14	and	and	CCONJ
biomedich-902	99	15	the	the	DET
biomedich-902	99	16	complex	complex	NOUN
biomedich-902	99	17	's	's	PART
biomedich-902	99	18	overall	overall	ADJ
biomedich-902	99	19	stability	stability	NOUN
biomedich-902	99	20	is	be	AUX
biomedich-902	99	21	enhanced	enhance	VERB
biomedich-902	99	22	by	by	ADP
biomedich-902	99	23	the	the	DET
biomedich-902	99	24	possibility	possibility	NOUN
biomedich-902	99	25	of	of	ADP
biomedich-902	99	26	pi	pi	NOUN
biomedich-902	99	27	-	-	PUNCT
biomedich-902	99	28	anion	anion	NOUN
biomedich-902	99	29	interactions	interaction	NOUN
biomedich-902	99	30	between	between	ADP
biomedich-902	99	31	the	the	DET
biomedich-902	99	32	negatively	negatively	ADV
biomedich-902	99	33	charged	charge	VERB
biomedich-902	99	34	groups	group	NOUN
biomedich-902	99	35	on	on	ADP
biomedich-902	99	36	insulin	insulin	NOUN
biomedich-902	99	37	and	and	CCONJ
biomedich-902	99	38	the	the	DET
biomedich-902	99	39	aromatic	aromatic	ADJ
biomedich-902	99	40	rings	ring	NOUN
biomedich-902	99	41	in	in	ADP
biomedich-902	99	42	vicine	vicine	NOUN
biomedich-902	99	43	.	.	PUNCT
biomedich-902	100	1	additionally	additionally	ADV
biomedich-902	100	2	,	,	PUNCT
biomedich-902	100	3	vicine	vicine	NOUN
biomedich-902	100	4	attaches	attach	VERB
biomedich-902	100	5	to	to	ADP
biomedich-902	100	6	gsk-3	gsk-3	VERB
biomedich-902	100	7	by	by	ADP
biomedich-902	100	8	a	a	DET
biomedich-902	100	9	combination	combination	NOUN
biomedich-902	100	10	of	of	ADP
biomedich-902	100	11	pi	pi	NOUN
biomedich-902	100	12	-	-	PUNCT
biomedich-902	100	13	alkyl	alkyl	ADJ
biomedich-902	100	14	interactions	interaction	NOUN
biomedich-902	100	15	,	,	PUNCT
biomedich-902	100	16	van	van	PROPN
biomedich-902	100	17	der	der	NOUN
biomedich-902	100	18	waals	waal	NOUN
biomedich-902	100	19	forces	force	NOUN
biomedich-902	100	20	,	,	PUNCT
biomedich-902	100	21	conventional	conventional	ADJ
biomedich-902	100	22	hydrogen	hydrogen	NOUN
biomedich-902	100	23	bonds	bond	NOUN
biomedich-902	100	24	,	,	PUNCT
biomedich-902	100	25	and	and	CCONJ
biomedich-902	100	26	carbon	carbon	NOUN
biomedich-902	100	27	hydrogen	hydrogen	NOUN
biomedich-902	100	28	bonds	bond	NOUN
biomedich-902	100	29	.	.	PUNCT
biomedich-902	101	1	this	this	DET
biomedich-902	101	2	wide	wide	ADJ
biomedich-902	101	3	variety	variety	NOUN
biomedich-902	101	4	of	of	ADP
biomedich-902	101	5	interactions	interaction	NOUN
biomedich-902	101	6	points	point	VERB
biomedich-902	101	7	to	to	ADP
biomedich-902	101	8	a	a	DET
biomedich-902	101	9	more	more	ADV
biomedich-902	101	10	complex	complex	ADJ
biomedich-902	101	11	and	and	CCONJ
biomedich-902	101	12	long	long	ADV
biomedich-902	101	13	-	-	PUNCT
biomedich-902	101	14	lasting	last	VERB
biomedich-902	101	15	binding	binding	NOUN
biomedich-902	101	16	with	with	ADP
biomedich-902	101	17	gsk-3	gsk-3	NOUN
biomedich-902	101	18	.	.	PUNCT
biomedich-902	102	1	vicine	vicine	PROPN
biomedich-902	102	2	probably	probably	ADV
biomedich-902	102	3	fits	fit	VERB
biomedich-902	102	4	well	well	ADV
biomedich-902	102	5	into	into	ADP
biomedich-902	102	6	the	the	DET
biomedich-902	102	7	active	active	ADJ
biomedich-902	102	8	or	or	CCONJ
biomedich-902	102	9	allosteric	allosteric	ADJ
biomedich-902	102	10	regions	region	NOUN
biomedich-902	102	11	of	of	ADP
biomedich-902	102	12	gsk-3	gsk-3	NOUN
biomedich-902	102	13	because	because	SCONJ
biomedich-902	102	14	carbon	carbon	NOUN
biomedich-902	102	15	hydrogen	hydrogen	NOUN
biomedich-902	102	16	bonds	bond	NOUN
biomedich-902	102	17	and	and	CCONJ
biomedich-902	102	18	pi	pi	NOUN
biomedich-902	102	19	-	-	PUNCT
biomedich-902	102	20	alkyl	alkyl	ADJ
biomedich-902	102	21	interactions	interaction	NOUN
biomedich-902	102	22	usually	usually	ADV
biomedich-902	102	23	improve	improve	VERB
biomedich-902	102	24	the	the	DET
biomedich-902	102	25	specificity	specificity	NOUN
biomedich-902	102	26	and	and	CCONJ
biomedich-902	102	27	strength	strength	NOUN
biomedich-902	102	28	of	of	ADP
biomedich-902	102	29	ligandenzyme	ligandenzyme	NOUN
biomedich-902	102	30	binding	bind	VERB
biomedich-902	102	31	.	.	PUNCT
biomedich-902	103	1	vicine	vicine	PROPN
biomedich-902	103	2	's	's	PART
biomedich-902	103	3	binding	binding	NOUN
biomedich-902	103	4	may	may	AUX
biomedich-902	103	5	alter	alter	VERB
biomedich-902	103	6	the	the	DET
biomedich-902	103	7	activity	activity	NOUN
biomedich-902	103	8	of	of	ADP
biomedich-902	103	9	gsk-3	gsk-3	NOUN
biomedich-902	103	10	,	,	PUNCT
biomedich-902	103	11	an	an	DET
biomedich-902	103	12	essential	essential	ADJ
biomedich-902	103	13	enzyme	enzyme	NOUN
biomedich-902	103	14	involved	involve	VERB
biomedich-902	103	15	in	in	ADP
biomedich-902	103	16	insulin	insulin	NOUN
biomedich-902	103	17	signaling	signal	VERB
biomedich-902	103	18	and	and	CCONJ
biomedich-902	103	19	glycogen	glycogen	NOUN
biomedich-902	103	20	metabolism	metabolism	NOUN
biomedich-902	103	21	,	,	PUNCT
biomedich-902	103	22	which	which	PRON
biomedich-902	103	23	could	could	AUX
biomedich-902	103	24	impact	impact	VERB
biomedich-902	103	25	cellular	cellular	ADJ
biomedich-902	103	26	functions	function	NOUN
biomedich-902	103	27	linked	link	VERB
biomedich-902	103	28	to	to	ADP
biomedich-902	103	29	glucose	glucose	NOUN
biomedich-902	103	30	absorption	absorption	NOUN
biomedich-902	103	31	and	and	CCONJ
biomedich-902	103	32	prasangika	prasangika	NOUN
biomedich-902	103	33	–	–	PUNCT
biomedich-902	103	34	bitter	bitter	ADJ
biomedich-902	103	35	melon	melon	NOUN
biomedich-902	103	36	:	:	PUNCT
biomedich-902	103	37	gsk-3	gsk-3	PUNCT
biomedich-902	103	38	and	and	CCONJ
biomedich-902	103	39	ir	ir	PROPN
biomedich-902	103	40	targets	target	NOUN
biomedich-902	103	41	1109	1109	NUM
biomedich-902	103	42	storage	storage	NOUN
biomedich-902	103	43	.	.	PUNCT
biomedich-902	104	1	all	all	DET
biomedich-902	104	2	things	thing	NOUN
biomedich-902	104	3	considered	consider	VERB
biomedich-902	104	4	,	,	PUNCT
biomedich-902	104	5	these	these	DET
biomedich-902	104	6	interactions	interaction	NOUN
biomedich-902	104	7	demonstrate	demonstrate	VERB
biomedich-902	104	8	that	that	SCONJ
biomedich-902	104	9	vicine	vicine	NOUN
biomedich-902	104	10	may	may	AUX
biomedich-902	104	11	influence	influence	VERB
biomedich-902	104	12	insulin	insulin	NOUN
biomedich-902	104	13	function	function	NOUN
biomedich-902	104	14	in	in	ADP
biomedich-902	104	15	two	two	NUM
biomedich-902	104	16	ways	way	NOUN
biomedich-902	104	17	:	:	PUNCT
biomedich-902	104	18	directly	directly	ADV
biomedich-902	104	19	stabilizing	stabilize	VERB
biomedich-902	104	20	insulin	insulin	NOUN
biomedich-902	104	21	molecules	molecule	NOUN
biomedich-902	104	22	and	and	CCONJ
biomedich-902	104	23	controlling	control	VERB
biomedich-902	104	24	important	important	ADJ
biomedich-902	104	25	enzymes	enzyme	NOUN
biomedich-902	104	26	such	such	ADJ
biomedich-902	104	27	as	as	ADP
biomedich-902	104	28	gsk-3	gsk-3	NOUN
biomedich-902	104	29	that	that	PRON
biomedich-902	104	30	are	be	AUX
biomedich-902	104	31	involved	involve	VERB
biomedich-902	104	32	in	in	ADP
biomedich-902	104	33	insulin	insulin	NOUN
biomedich-902	104	34	signaling	signal	VERB
biomedich-902	104	35	pathways	pathway	NOUN
biomedich-902	104	36	.	.	PUNCT
biomedich-902	105	1	vicine	vicine	PROPN
biomedich-902	105	2	's	's	PART
biomedich-902	105	3	pharmacological	pharmacological	ADJ
biomedich-902	105	4	usefulness	usefulness	NOUN
biomedich-902	105	5	in	in	ADP
biomedich-902	105	6	controlling	control	VERB
biomedich-902	105	7	glucose	glucose	NOUN
biomedich-902	105	8	metabolism	metabolism	NOUN
biomedich-902	105	9	is	be	AUX
biomedich-902	105	10	highlighted	highlight	VERB
biomedich-902	105	11	by	by	ADP
biomedich-902	105	12	this	this	DET
biomedich-902	105	13	multi	multi	ADJ
biomedich-902	105	14	-	-	ADJ
biomedich-902	105	15	targeted	target	VERB
biomedich-902	105	16	interaction	interaction	NOUN
biomedich-902	105	17	pattern	pattern	NOUN
biomedich-902	105	18	,	,	PUNCT
biomedich-902	105	19	which	which	PRON
biomedich-902	105	20	also	also	ADV
biomedich-902	105	21	points	point	VERB
biomedich-902	105	22	to	to	ADP
biomedich-902	105	23	its	its	PRON
biomedich-902	105	24	potential	potential	ADJ
biomedich-902	105	25	use	use	NOUN
biomedich-902	105	26	in	in	ADP
biomedich-902	105	27	treatment	treatment	NOUN
biomedich-902	105	28	approaches	approach	NOUN
biomedich-902	105	29	for	for	ADP
biomedich-902	105	30	diabetes	diabetes	NOUN
biomedich-902	105	31	and	and	CCONJ
biomedich-902	105	32	insulin	insulin	NOUN
biomedich-902	105	33	resistance	resistance	NOUN
biomedich-902	105	34	.	.	PUNCT
biomedich-902	106	1	admet	admet	PROPN
biomedich-902	106	2	properties	property	NOUN
biomedich-902	106	3	of	of	ADP
biomedich-902	106	4	charantin	charantin	NOUN
biomedich-902	106	5	and	and	CCONJ
biomedich-902	106	6	vicine	vicine	ADJ
biomedich-902	106	7	table	table	NOUN
biomedich-902	106	8	2	2	NUM
biomedich-902	106	9	.	.	PUNCT
biomedich-902	106	10	comparative	comparative	ADJ
biomedich-902	106	11	analysis	analysis	NOUN
biomedich-902	106	12	of	of	ADP
biomedich-902	106	13	admet	admet	NOUN
biomedich-902	106	14	properties	property	NOUN
biomedich-902	106	15	of	of	ADP
biomedich-902	106	16	two	two	NUM
biomedich-902	106	17	phytochemicals	phytochemical	NOUN
biomedich-902	106	18	.	.	PUNCT
biomedich-902	107	1	admet	admet	PROPN
biomedich-902	107	2	parameter	parameter	PROPN
biomedich-902	107	3	charantin	charantin	PROPN
biomedich-902	107	4	vicine	vicine	ADJ
biomedich-902	107	5	intestinal	intestinal	ADJ
biomedich-902	107	6	absorption	absorption	NOUN
biomedich-902	107	7	(	(	PUNCT
biomedich-902	107	8	%	%	INTJ
biomedich-902	107	9	)	)	PUNCT
biomedich-902	107	10	79.677	79.677	NUM
biomedich-902	107	11	28.87	28.87	NUM
biomedich-902	107	12	water	water	NOUN
biomedich-902	107	13	solubility(log	solubility(log	NOUN
biomedich-902	107	14	mol	mol	PROPN
biomedich-902	107	15	/	/	SYM
biomedich-902	107	16	l	l	NOUN
biomedich-902	107	17	)	)	PUNCT
biomedich-902	107	18	-4.741	-4.741	PUNCT
biomedich-902	107	19	-2.689	-2.689	PUNCT
biomedich-902	107	20	vdss	vdss	ADV
biomedich-902	107	21	(	(	PUNCT
biomedich-902	107	22	human	human	NOUN
biomedich-902	107	23	)	)	PUNCT
biomedich-902	107	24	(	(	PUNCT
biomedich-902	107	25	logl	logl	NOUN
biomedich-902	107	26	/	/	SYM
biomedich-902	107	27	kg	kg	NOUN
biomedich-902	107	28	)	)	PUNCT
biomedich-902	107	29	-1.163	-1.163	PROPN
biomedich-902	107	30	0.988	0.988	NUM
biomedich-902	107	31	total	total	ADJ
biomedich-902	107	32	clearance	clearance	NOUN
biomedich-902	107	33	0.689	0.689	NUM
biomedich-902	107	34	0.252	0.252	NUM
biomedich-902	107	35	ld50(mg	ld50(mg	PROPN
biomedich-902	107	36	/	/	SYM
biomedich-902	107	37	kg	kg	NOUN
biomedich-902	107	38	)	)	PUNCT
biomedich-902	107	39	8000	8000	NUM
biomedich-902	107	40	1000	1000	NUM
biomedich-902	107	41	toxicity	toxicity	NOUN
biomedich-902	107	42	class	class	NOUN
biomedich-902	107	43	6	6	NUM
biomedich-902	107	44	4	4	NUM
biomedich-902	107	45	charantin	charantin	NOUN
biomedich-902	107	46	and	and	CCONJ
biomedich-902	107	47	vicine	vicine	NOUN
biomedich-902	107	48	's	's	PART
biomedich-902	107	49	drug	drug	NOUN
biomedich-902	107	50	-	-	PUNCT
biomedich-902	107	51	likeness	likeness	NOUN
biomedich-902	107	52	and	and	CCONJ
biomedich-902	107	53	pharmacokinetic	pharmacokinetic	ADJ
biomedich-902	107	54	profiles	profile	NOUN
biomedich-902	107	55	differ	differ	VERB
biomedich-902	107	56	significantly	significantly	ADV
biomedich-902	107	57	,	,	PUNCT
biomedich-902	107	58	according	accord	VERB
biomedich-902	107	59	to	to	ADP
biomedich-902	107	60	the	the	DET
biomedich-902	107	61	admet	admet	PROPN
biomedich-902	107	62	analysis	analysis	NOUN
biomedich-902	107	63	.	.	PUNCT
biomedich-902	108	1	when	when	SCONJ
biomedich-902	108	2	taken	take	VERB
biomedich-902	108	3	orally	orally	ADV
biomedich-902	108	4	,	,	PUNCT
biomedich-902	108	5	charantin	charantin	PROPN
biomedich-902	108	6	exhibits	exhibit	VERB
biomedich-902	108	7	a	a	DET
biomedich-902	108	8	significantly	significantly	ADV
biomedich-902	108	9	higher	high	ADJ
biomedich-902	108	10	intestinal	intestinal	ADJ
biomedich-902	108	11	absorption	absorption	NOUN
biomedich-902	108	12	rate	rate	NOUN
biomedich-902	108	13	(	(	PUNCT
biomedich-902	108	14	79.68	79.68	NUM
biomedich-902	108	15	%	%	NOUN
biomedich-902	108	16	)	)	PUNCT
biomedich-902	108	17	than	than	ADP
biomedich-902	108	18	vicine	vicine	ADJ
biomedich-902	108	19	(	(	PUNCT
biomedich-902	108	20	28.87	28.87	NUM
biomedich-902	108	21	%	%	NOUN
biomedich-902	108	22	)	)	PUNCT
biomedich-902	108	23	,	,	PUNCT
biomedich-902	108	24	suggesting	suggest	VERB
biomedich-902	108	25	superior	superior	ADJ
biomedich-902	108	26	bioavailability	bioavailability	NOUN
biomedich-902	108	27	.	.	PUNCT
biomedich-902	109	1	charantin	charantin	PROPN
biomedich-902	109	2	,	,	PUNCT
biomedich-902	109	3	on	on	ADP
biomedich-902	109	4	the	the	DET
biomedich-902	109	5	other	other	ADJ
biomedich-902	109	6	hand	hand	NOUN
biomedich-902	109	7	,	,	PUNCT
biomedich-902	109	8	is	be	AUX
biomedich-902	109	9	less	less	ADV
biomedich-902	109	10	soluble	soluble	ADJ
biomedich-902	109	11	in	in	ADP
biomedich-902	109	12	aqueous	aqueous	ADJ
biomedich-902	109	13	environments	environment	NOUN
biomedich-902	109	14	than	than	ADP
biomedich-902	109	15	vicine	vicine	NOUN
biomedich-902	109	16	(	(	PUNCT
biomedich-902	109	17	log	log	PROPN
biomedich-902	109	18	mol	mol	PROPN
biomedich-902	109	19	/	/	SYM
biomedich-902	109	20	l	l	NOUN
biomedich-902	109	21	-2.689	-2.689	NOUN
biomedich-902	109	22	)	)	PUNCT
biomedich-902	109	23	,	,	PUNCT
biomedich-902	109	24	which	which	PRON
biomedich-902	109	25	may	may	AUX
biomedich-902	109	26	have	have	VERB
biomedich-902	109	27	an	an	DET
biomedich-902	109	28	impact	impact	NOUN
biomedich-902	109	29	on	on	ADP
biomedich-902	109	30	its	its	PRON
biomedich-902	109	31	formulation	formulation	NOUN
biomedich-902	109	32	and	and	CCONJ
biomedich-902	109	33	absorption	absorption	NOUN
biomedich-902	109	34	dynamics	dynamic	NOUN
biomedich-902	109	35	.	.	PUNCT
biomedich-902	110	1	in	in	ADP
biomedich-902	110	2	terms	term	NOUN
biomedich-902	110	3	of	of	ADP
biomedich-902	110	4	distribution	distribution	NOUN
biomedich-902	110	5	,	,	PUNCT
biomedich-902	110	6	vicine	vicine	PROPN
biomedich-902	110	7	shows	show	VERB
biomedich-902	110	8	a	a	DET
biomedich-902	110	9	higher	high	ADJ
biomedich-902	110	10	potential	potential	NOUN
biomedich-902	110	11	for	for	ADP
biomedich-902	110	12	distribution	distribution	NOUN
biomedich-902	110	13	(	(	PUNCT
biomedich-902	110	14	0.988	0.988	NUM
biomedich-902	110	15	)	)	PUNCT
biomedich-902	110	16	,	,	PUNCT
biomedich-902	110	17	suggesting	suggest	VERB
biomedich-902	110	18	that	that	SCONJ
biomedich-902	110	19	it	it	PRON
biomedich-902	110	20	may	may	AUX
biomedich-902	110	21	spread	spread	VERB
biomedich-902	110	22	more	more	ADV
biomedich-902	110	23	widely	widely	ADV
biomedich-902	110	24	throughout	throughout	ADP
biomedich-902	110	25	the	the	DET
biomedich-902	110	26	body	body	NOUN
biomedich-902	110	27	,	,	PUNCT
biomedich-902	110	28	whereas	whereas	SCONJ
biomedich-902	110	29	charantin	charantin	NOUN
biomedich-902	110	30	displays	display	VERB
biomedich-902	110	31	a	a	DET
biomedich-902	110	32	low	low	ADJ
biomedich-902	110	33	volume	volume	NOUN
biomedich-902	110	34	of	of	ADP
biomedich-902	110	35	distribution	distribution	NOUN
biomedich-902	110	36	(	(	PUNCT
biomedich-902	110	37	vdss	vdss	ADV
biomedich-902	110	38	,	,	PUNCT
biomedich-902	110	39	log	log	VERB
biomedich-902	110	40	l	l	NOUN
biomedich-902	110	41	/	/	SYM
biomedich-902	110	42	kg	kg	NOUN
biomedich-902	110	43	-1.163	-1.163	PROPN
biomedich-902	110	44	)	)	PUNCT
biomedich-902	110	45	,	,	PUNCT
biomedich-902	110	46	suggesting	suggest	VERB
biomedich-902	110	47	restricted	restrict	VERB
biomedich-902	110	48	tissue	tissue	NOUN
biomedich-902	110	49	penetration	penetration	NOUN
biomedich-902	110	50	and	and	CCONJ
biomedich-902	110	51	retention	retention	NOUN
biomedich-902	110	52	.	.	PUNCT
biomedich-902	111	1	the	the	DET
biomedich-902	111	2	fact	fact	NOUN
biomedich-902	111	3	that	that	SCONJ
biomedich-902	111	4	charantin	charantin	PROPN
biomedich-902	111	5	's	's	PART
biomedich-902	111	6	total	total	ADJ
biomedich-902	111	7	clearance	clearance	NOUN
biomedich-902	111	8	(	(	PUNCT
biomedich-902	111	9	0.689	0.689	NUM
biomedich-902	111	10	)	)	PUNCT
biomedich-902	111	11	is	be	AUX
biomedich-902	111	12	greater	great	ADJ
biomedich-902	111	13	than	than	ADP
biomedich-902	111	14	vicine	vicine	NOUN
biomedich-902	111	15	's	's	PART
biomedich-902	111	16	(	(	PUNCT
biomedich-902	111	17	0.252	0.252	NUM
biomedich-902	111	18	)	)	PUNCT
biomedich-902	111	19	indicates	indicate	VERB
biomedich-902	111	20	that	that	SCONJ
biomedich-902	111	21	charantin	charantin	PROPN
biomedich-902	111	22	gets	get	AUX
biomedich-902	111	23	removed	remove	VERB
biomedich-902	111	24	from	from	ADP
biomedich-902	111	25	the	the	DET
biomedich-902	111	26	body	body	NOUN
biomedich-902	111	27	more	more	ADV
biomedich-902	111	28	quickly	quickly	ADV
biomedich-902	111	29	,	,	PUNCT
biomedich-902	111	30	which	which	PRON
biomedich-902	111	31	may	may	AUX
biomedich-902	111	32	have	have	VERB
biomedich-902	111	33	an	an	DET
biomedich-902	111	34	impact	impact	NOUN
biomedich-902	111	35	on	on	ADP
biomedich-902	111	36	how	how	SCONJ
biomedich-902	111	37	frequently	frequently	ADV
biomedich-902	111	38	it	it	PRON
biomedich-902	111	39	is	be	AUX
biomedich-902	111	40	taken	take	VERB
biomedich-902	111	41	.	.	PUNCT
biomedich-902	112	1	these	these	DET
biomedich-902	112	2	chemicals	chemical	NOUN
biomedich-902	112	3	are	be	AUX
biomedich-902	112	4	further	far	ADV
biomedich-902	112	5	distinguished	distinguish	VERB
biomedich-902	112	6	by	by	ADP
biomedich-902	112	7	toxicity	toxicity	NOUN
biomedich-902	112	8	parameters	parameter	NOUN
biomedich-902	112	9	:	:	PUNCT
biomedich-902	112	10	vicine	vicine	PROPN
biomedich-902	112	11	's	's	PART
biomedich-902	112	12	ld50	ld50	PROPN
biomedich-902	112	13	value	value	NOUN
biomedich-902	112	14	is	be	AUX
biomedich-902	112	15	1000	1000	NUM
biomedich-902	112	16	mg	mg	PROPN
biomedich-902	112	17	/	/	SYM
biomedich-902	112	18	kg	kg	PROPN
biomedich-902	112	19	,	,	PUNCT
biomedich-902	112	20	but	but	CCONJ
biomedich-902	112	21	charantin	charantin	PROPN
biomedich-902	112	22	's	's	PART
biomedich-902	112	23	is	be	AUX
biomedich-902	112	24	8000	8000	NUM
biomedich-902	112	25	mg	mg	PROPN
biomedich-902	112	26	/	/	SYM
biomedich-902	112	27	kg	kg	PROPN
biomedich-902	112	28	,	,	PUNCT
biomedich-902	112	29	suggesting	suggest	VERB
biomedich-902	112	30	a	a	DET
biomedich-902	112	31	far	far	ADV
biomedich-902	112	32	lower	low	ADJ
biomedich-902	112	33	risk	risk	NOUN
biomedich-902	112	34	of	of	ADP
biomedich-902	112	35	acute	acute	ADJ
biomedich-902	112	36	toxicity	toxicity	NOUN
biomedich-902	112	37	.	.	PUNCT
biomedich-902	113	1	(	(	PUNCT
biomedich-902	113	2	as	as	SCONJ
biomedich-902	113	3	shown	show	VERB
biomedich-902	113	4	table	table	NOUN
biomedich-902	113	5	2	2	NUM
biomedich-902	113	6	)	)	PUNCT
biomedich-902	113	7	as	as	ADP
biomedich-902	113	8	a	a	DET
biomedich-902	113	9	result	result	NOUN
biomedich-902	113	10	,	,	PUNCT
biomedich-902	113	11	charantin	charantin	PROPN
biomedich-902	113	12	may	may	AUX
biomedich-902	113	13	be	be	AUX
biomedich-902	113	14	safer	safe	ADJ
biomedich-902	113	15	for	for	ADP
biomedich-902	113	16	therapeutic	therapeutic	ADJ
biomedich-902	113	17	uses	use	NOUN
biomedich-902	113	18	because	because	SCONJ
biomedich-902	113	19	it	it	PRON
biomedich-902	113	20	is	be	AUX
biomedich-902	113	21	a	a	DET
biomedich-902	113	22	member	member	NOUN
biomedich-902	113	23	of	of	ADP
biomedich-902	113	24	a	a	DET
biomedich-902	113	25	less	less	ADV
biomedich-902	113	26	hazardous	hazardous	ADJ
biomedich-902	113	27	class	class	NOUN
biomedich-902	113	28	(	(	PUNCT
biomedich-902	113	29	class	class	NOUN
biomedich-902	113	30	6	6	NUM
biomedich-902	113	31	)	)	PUNCT
biomedich-902	113	32	than	than	ADP
biomedich-902	113	33	vicine	vicine	ADJ
biomedich-902	113	34	(	(	PUNCT
biomedich-902	113	35	class	class	NOUN
biomedich-902	113	36	4	4	NUM
biomedich-902	113	37	)	)	PUNCT
biomedich-902	113	38	.	.	PUNCT
biomedich-902	114	1	(	(	PUNCT
biomedich-902	114	2	as	as	SCONJ
biomedich-902	114	3	shown	show	VERB
biomedich-902	114	4	in	in	ADP
biomedich-902	114	5	table	table	NOUN
biomedich-902	114	6	2	2	NUM
biomedich-902	114	7	)	)	PUNCT
biomedich-902	114	8	.	.	PUNCT
biomedich-902	115	1	despite	despite	SCONJ
biomedich-902	115	2	having	have	VERB
biomedich-902	115	3	a	a	DET
biomedich-902	115	4	lesser	less	ADJ
biomedich-902	115	5	volume	volume	NOUN
biomedich-902	115	6	of	of	ADP
biomedich-902	115	7	distribution	distribution	NOUN
biomedich-902	115	8	and	and	CCONJ
biomedich-902	115	9	water	water	NOUN
biomedich-902	115	10	solubility	solubility	NOUN
biomedich-902	115	11	than	than	ADP
biomedich-902	115	12	vicine	vicine	NOUN
biomedich-902	115	13	,	,	PUNCT
biomedich-902	115	14	charantin	charantin	PROPN
biomedich-902	115	15	has	have	VERB
biomedich-902	115	16	more	more	ADV
biomedich-902	115	17	advantageous	advantageous	ADJ
biomedich-902	115	18	admet	admet	NOUN
biomedich-902	115	19	properties	property	NOUN
biomedich-902	115	20	overall	overall	ADJ
biomedich-902	115	21	,	,	PUNCT
biomedich-902	115	22	including	include	VERB
biomedich-902	115	23	better	well	ADJ
biomedich-902	115	24	intestinal	intestinal	ADJ
biomedich-902	115	25	absorption	absorption	NOUN
biomedich-902	115	26	and	and	CCONJ
biomedich-902	115	27	reduced	reduced	ADJ
biomedich-902	115	28	toxicity	toxicity	NOUN
biomedich-902	115	29	.	.	PUNCT
biomedich-902	116	1	although	although	SCONJ
biomedich-902	116	2	formulation	formulation	NOUN
biomedich-902	116	3	strategies	strategy	NOUN
biomedich-902	116	4	may	may	AUX
biomedich-902	116	5	be	be	AUX
biomedich-902	116	6	required	require	VERB
biomedich-902	116	7	to	to	PART
biomedich-902	116	8	address	address	VERB
biomedich-902	116	9	its	its	PRON
biomedich-902	116	10	solubility	solubility	NOUN
biomedich-902	116	11	limits	limit	NOUN
biomedich-902	116	12	,	,	PUNCT
biomedich-902	116	13	these	these	DET
biomedich-902	116	14	modifications	modification	NOUN
biomedich-902	116	15	imply	imply	VERB
biomedich-902	116	16	that	that	SCONJ
biomedich-902	116	17	charantin	charantin	PROPN
biomedich-902	116	18	may	may	AUX
biomedich-902	116	19	have	have	VERB
biomedich-902	116	20	higher	high	ADJ
biomedich-902	116	21	oral	oral	ADJ
biomedich-902	116	22	bioavailability	bioavailability	NOUN
biomedich-902	116	23	and	and	CCONJ
biomedich-902	116	24	safety	safety	NOUN
biomedich-902	116	25	characteristics	characteristic	NOUN
biomedich-902	116	26	,	,	PUNCT
biomedich-902	116	27	making	make	VERB
biomedich-902	116	28	it	it	PRON
biomedich-902	116	29	potentially	potentially	ADV
biomedich-902	116	30	more	more	ADV
biomedich-902	116	31	suited	suited	ADJ
biomedich-902	116	32	for	for	ADP
biomedich-902	116	33	therapeutic	therapeutic	ADJ
biomedich-902	116	34	development	development	NOUN
biomedich-902	116	35	.	.	PUNCT
biomedich-902	117	1	vicine	vicine	PROPN
biomedich-902	117	2	has	have	VERB
biomedich-902	117	3	superior	superior	ADJ
biomedich-902	117	4	solubility	solubility	NOUN
biomedich-902	117	5	and	and	CCONJ
biomedich-902	117	6	tissue	tissue	NOUN
biomedich-902	117	7	distribution	distribution	NOUN
biomedich-902	117	8	,	,	PUNCT
biomedich-902	117	9	but	but	CCONJ
biomedich-902	117	10	its	its	PRON
biomedich-902	117	11	therapeutic	therapeutic	ADJ
biomedich-902	117	12	window	window	NOUN
biomedich-902	117	13	may	may	AUX
biomedich-902	117	14	be	be	AUX
biomedich-902	117	15	limited	limit	VERB
biomedich-902	117	16	by	by	ADP
biomedich-902	117	17	its	its	PRON
biomedich-902	117	18	increased	increase	VERB
biomedich-902	117	19	toxicity	toxicity	NOUN
biomedich-902	117	20	and	and	CCONJ
biomedich-902	117	21	poorer	poor	ADJ
biomedich-902	117	22	absorption	absorption	NOUN
biomedich-902	117	23	.	.	PUNCT
biomedich-902	118	1	prioritizing	prioritize	VERB
biomedich-902	118	2	these	these	DET
biomedich-902	118	3	phytochemicals	phytochemical	NOUN
biomedich-902	118	4	for	for	ADP
biomedich-902	118	5	additional	additional	ADJ
biomedich-902	118	6	pharmacological	pharmacological	ADJ
biomedich-902	118	7	and	and	CCONJ
biomedich-902	118	8	clinical	clinical	ADJ
biomedich-902	118	9	research	research	NOUN
biomedich-902	118	10	is	be	AUX
biomedich-902	118	11	made	make	VERB
biomedich-902	118	12	easier	easy	ADJ
biomedich-902	118	13	by	by	ADP
biomedich-902	118	14	this	this	DET
biomedich-902	118	15	comparative	comparative	ADJ
biomedich-902	118	16	admet	admet	NOUN
biomedich-902	118	17	profile	profile	NOUN
biomedich-902	118	18	.	.	PUNCT
biomedich-902	119	1	conclusions	conclusion	NOUN
biomedich-902	119	2	in	in	ADP
biomedich-902	119	3	conclusion	conclusion	NOUN
biomedich-902	119	4	,	,	PUNCT
biomedich-902	119	5	charantin	charantin	PROPN
biomedich-902	119	6	shows	show	VERB
biomedich-902	119	7	great	great	ADJ
biomedich-902	119	8	promise	promise	NOUN
biomedich-902	119	9	as	as	ADP
biomedich-902	119	10	a	a	DET
biomedich-902	119	11	multitarget	multitarget	PROPN
biomedich-902	119	12	natural	natural	ADJ
biomedich-902	119	13	antidiabetic	antidiabetic	ADJ
biomedich-902	119	14	drug	drug	NOUN
biomedich-902	119	15	,	,	PUNCT
biomedich-902	119	16	outperforming	outperforming	NOUN
biomedich-902	119	17	vicine	vicine	NOUN
biomedich-902	119	18	in	in	ADP
biomedich-902	119	19	a	a	DET
biomedich-902	119	20	number	number	NOUN
biomedich-902	119	21	of	of	ADP
biomedich-902	119	22	crucial	crucial	ADJ
biomedich-902	119	23	areas	area	NOUN
biomedich-902	119	24	,	,	PUNCT
biomedich-902	119	25	according	accord	VERB
biomedich-902	119	26	to	to	ADP
biomedich-902	119	27	both	both	PRON
biomedich-902	119	28	molecular	molecular	ADJ
biomedich-902	119	29	docking	docking	NOUN
biomedich-902	119	30	and	and	CCONJ
biomedich-902	119	31	admet	admet	PROPN
biomedich-902	119	32	studies	study	NOUN
biomedich-902	119	33	.	.	PUNCT
biomedich-902	120	1	strong	strong	ADJ
biomedich-902	120	2	hydrogen	hydrogen	NOUN
biomedich-902	120	3	bonds	bond	NOUN
biomedich-902	120	4	and	and	CCONJ
biomedich-902	120	5	a	a	DET
biomedich-902	120	6	variety	variety	NOUN
biomedich-902	120	7	of	of	ADP
biomedich-902	120	8	hydrophobic	hydrophobic	NOUN
biomedich-902	120	9	contacts	contact	NOUN
biomedich-902	120	10	enable	enable	VERB
biomedich-902	120	11	charantin	charantin	NOUN
biomedich-902	120	12	to	to	PART
biomedich-902	120	13	bind	bind	VERB
biomedich-902	120	14	to	to	ADP
biomedich-902	120	15	both	both	DET
biomedich-902	120	16	gsk-3	gsk-3	PUNCT
biomedich-902	120	17	and	and	CCONJ
biomedich-902	120	18	the	the	DET
biomedich-902	120	19	insulin	insulin	NOUN
biomedich-902	120	20	receptor	receptor	NOUN
biomedich-902	120	21	with	with	ADP
biomedich-902	120	22	noticeably	noticeably	ADV
biomedich-902	120	23	increased	increase	VERB
biomedich-902	120	24	affinities	affinity	NOUN
biomedich-902	120	25	.	.	PUNCT
biomedich-902	121	1	these	these	DET
biomedich-902	121	2	changes	change	NOUN
biomedich-902	121	3	result	result	VERB
biomedich-902	121	4	in	in	ADP
biomedich-902	121	5	more	more	ADV
biomedich-902	121	6	stable	stable	ADJ
biomedich-902	121	7	and	and	CCONJ
biomedich-902	121	8	efficient	efficient	ADJ
biomedich-902	121	9	adjustments	adjustment	NOUN
biomedich-902	121	10	to	to	ADP
biomedich-902	121	11	insulin	insulin	NOUN
biomedich-902	121	12	signaling	signal	VERB
biomedich-902	121	13	and	and	CCONJ
biomedich-902	121	14	glucose	glucose	NOUN
biomedich-902	121	15	regulation	regulation	NOUN
biomedich-902	121	16	systems	system	NOUN
biomedich-902	121	17	.	.	PUNCT
biomedich-902	122	1	even	even	ADV
biomedich-902	122	2	though	though	SCONJ
biomedich-902	122	3	charantin	charantin	PROPN
biomedich-902	122	4	has	have	VERB
biomedich-902	122	5	certain	certain	ADJ
biomedich-902	122	6	limits	limit	NOUN
biomedich-902	122	7	in	in	ADP
biomedich-902	122	8	terms	term	NOUN
biomedich-902	122	9	of	of	ADP
biomedich-902	122	10	water	water	NOUN
biomedich-902	122	11	solubility	solubility	NOUN
biomedich-902	122	12	and	and	CCONJ
biomedich-902	122	13	tissue	tissue	NOUN
biomedich-902	122	14	distribution	distribution	NOUN
biomedich-902	122	15	,	,	PUNCT
biomedich-902	122	16	these	these	DET
biomedich-902	122	17	molecular	molecular	ADJ
biomedich-902	122	18	characteristics	characteristic	NOUN
biomedich-902	122	19	,	,	PUNCT
biomedich-902	122	20	along	along	ADP
biomedich-902	122	21	with	with	ADP
biomedich-902	122	22	its	its	PRON
biomedich-902	122	23	superior	superior	ADJ
biomedich-902	122	24	intestinal	intestinal	ADJ
biomedich-902	122	25	absorption	absorption	NOUN
biomedich-902	122	26	and	and	CCONJ
biomedich-902	122	27	significantly	significantly	ADV
biomedich-902	122	28	reduced	reduce	VERB
biomedich-902	122	29	toxicity	toxicity	NOUN
biomedich-902	122	30	,	,	PUNCT
biomedich-902	122	31	greatly	greatly	ADV
biomedich-902	122	32	enhance	enhance	VERB
biomedich-902	122	33	its	its	PRON
biomedich-902	122	34	drug	drug	NOUN
biomedich-902	122	35	-	-	PUNCT
biomedich-902	122	36	likeness	likeness	NOUN
biomedich-902	122	37	and	and	CCONJ
biomedich-902	122	38	therapeutic	therapeutic	ADJ
biomedich-902	122	39	prospects	prospect	NOUN
biomedich-902	122	40	.	.	PUNCT
biomedich-902	123	1	vicine	vicine	PROPN
biomedich-902	123	2	,	,	PUNCT
biomedich-902	123	3	on	on	ADP
biomedich-902	123	4	the	the	DET
biomedich-902	123	5	other	other	ADJ
biomedich-902	123	6	hand	hand	NOUN
biomedich-902	123	7	,	,	PUNCT
biomedich-902	123	8	has	have	VERB
biomedich-902	123	9	a	a	DET
biomedich-902	123	10	reduced	reduce	VERB
biomedich-902	123	11	binding	bind	VERB
biomedich-902	123	12	potential	potential	NOUN
biomedich-902	123	13	,	,	PUNCT
biomedich-902	123	14	limited	limited	ADJ
biomedich-902	123	15	absorption	absorption	NOUN
biomedich-902	123	16	,	,	PUNCT
biomedich-902	123	17	and	and	CCONJ
biomedich-902	123	18	increased	increase	VERB
biomedich-902	123	19	toxicity	toxicity	NOUN
biomedich-902	123	20	,	,	PUNCT
biomedich-902	123	21	which	which	PRON
biomedich-902	123	22	may	may	AUX
biomedich-902	123	23	limit	limit	VERB
biomedich-902	123	24	its	its	PRON
biomedich-902	123	25	potential	potential	NOUN
biomedich-902	123	26	as	as	ADP
biomedich-902	123	27	a	a	DET
biomedich-902	123	28	therapeutic	therapeutic	ADJ
biomedich-902	123	29	agent	agent	NOUN
biomedich-902	123	30	even	even	ADV
biomedich-902	123	31	if	if	SCONJ
biomedich-902	123	32	it	it	PRON
biomedich-902	123	33	has	have	VERB
biomedich-902	123	34	superior	superior	ADJ
biomedich-902	123	35	water	water	NOUN
biomedich-902	123	36	solubility	solubility	NOUN
biomedich-902	123	37	and	and	CCONJ
biomedich-902	123	38	a	a	DET
biomedich-902	123	39	wider	wide	ADJ
biomedich-902	123	40	tissue	tissue	NOUN
biomedich-902	123	41	distribution	distribution	NOUN
biomedich-902	123	42	.	.	PUNCT
biomedich-902	124	1	overall	overall	ADJ
biomedich-902	124	2	,	,	PUNCT
biomedich-902	124	3	charantin	charantin	PROPN
biomedich-902	124	4	's	's	PART
biomedich-902	124	5	good	good	ADJ
biomedich-902	124	6	pharmacokinetic	pharmacokinetic	ADJ
biomedich-902	124	7	characteristics	characteristic	NOUN
biomedich-902	124	8	and	and	CCONJ
biomedich-902	124	9	potent	potent	ADJ
biomedich-902	124	10	multi	multi	ADJ
biomedich-902	124	11	-	-	ADJ
biomedich-902	124	12	target	target	ADJ
biomedich-902	124	13	protein	protein	NOUN
biomedich-902	124	14	interactions	interaction	NOUN
biomedich-902	124	15	support	support	VERB
biomedich-902	124	16	its	its	PRON
biomedich-902	124	17	continued	continue	VERB
biomedich-902	124	18	development	development	NOUN
biomedich-902	124	19	as	as	ADP
biomedich-902	124	20	a	a	DET
biomedich-902	124	21	safer	safe	ADJ
biomedich-902	124	22	and	and	CCONJ
biomedich-902	124	23	more	more	ADV
biomedich-902	124	24	effective	effective	ADJ
biomedich-902	124	25	natural	natural	ADJ
biomedich-902	124	26	diabetes	diabetes	NOUN
biomedich-902	124	27	medication	medication	NOUN
biomedich-902	124	28	.	.	PUNCT
biomedich-902	125	1	these	these	DET
biomedich-902	125	2	strong	strong	ADJ
biomedich-902	125	3	arguments	argument	NOUN
biomedich-902	125	4	support	support	VERB
biomedich-902	125	5	more	more	ADV
biomedich-902	125	6	thorough	thorough	ADJ
biomedich-902	125	7	clinical	clinical	ADJ
biomedich-902	125	8	and	and	CCONJ
biomedich-902	125	9	pharmacological	pharmacological	ADJ
biomedich-902	125	10	research	research	NOUN
biomedich-902	125	11	to	to	PART
biomedich-902	125	12	fully	fully	ADV
biomedich-902	125	13	understand	understand	VERB
biomedich-902	125	14	charantin	charantin	PROPN
biomedich-902	125	15	's	's	PART
biomedich-902	125	16	potential	potential	NOUN
biomedich-902	125	17	in	in	ADP
biomedich-902	125	18	the	the	DET
biomedich-902	125	19	treatment	treatment	NOUN
biomedich-902	125	20	of	of	ADP
biomedich-902	125	21	diabetes	diabetes	NOUN
biomedich-902	125	22	.	.	PUNCT
biomedich-902	126	1	acknowledgements	acknowledgement	NOUN
biomedich-902	126	2	:	:	PUNCT
biomedich-902	127	1	i	i	PRON
biomedich-902	127	2	want	want	VERB
biomedich-902	127	3	to	to	PART
biomedich-902	127	4	express	express	VERB
biomedich-902	127	5	my	my	PRON
biomedich-902	127	6	sincere	sincere	ADJ
biomedich-902	127	7	gratitude	gratitude	NOUN
biomedich-902	127	8	to	to	ADP
biomedich-902	127	9	all	all	PRON
biomedich-902	127	10	of	of	ADP
biomedich-902	127	11	the	the	DET
biomedich-902	127	12	university	university	PROPN
biomedich-902	127	13	of	of	ADP
biomedich-902	127	14	kelaniya	kelaniya	PROPN
biomedich-902	127	15	supporters	supporter	NOUN
biomedich-902	127	16	for	for	ADP
biomedich-902	127	17	their	their	PRON
biomedich-902	127	18	crucial	crucial	ADJ
biomedich-902	127	19	advice	advice	NOUN
biomedich-902	127	20	and	and	CCONJ
biomedich-902	127	21	help	help	NOUN
biomedich-902	127	22	during	during	ADP
biomedich-902	127	23	this	this	DET
biomedich-902	127	24	project	project	NOUN
biomedich-902	127	25	.	.	PUNCT
biomedich-902	128	1	authors	author	NOUN
biomedich-902	128	2	’	’	PART
biomedich-902	128	3	contributions	contribution	NOUN
biomedich-902	128	4	:	:	PUNCT
biomedich-902	128	5	conceptualization	conceptualization	NOUN
biomedich-902	128	6	,	,	PUNCT
biomedich-902	128	7	manuscript	manuscript	NOUN
biomedich-902	128	8	writing	writing	NOUN
biomedich-902	128	9	and	and	CCONJ
biomedich-902	128	10	computational	computational	ADJ
biomedich-902	128	11	simulations	simulation	NOUN
biomedich-902	128	12	:	:	PUNCT
biomedich-902	128	13	nalini	nalini	PROPN
biomedich-902	128	14	prasangika	prasangika	NOUN
biomedich-902	128	15	.	.	PUNCT
biomedich-902	129	1	competing	compete	VERB
biomedich-902	129	2	interests	interest	NOUN
biomedich-902	129	3	:	:	PUNCT
biomedich-902	129	4	the	the	DET
biomedich-902	129	5	authors	author	NOUN
biomedich-902	129	6	declare	declare	VERB
biomedich-902	129	7	that	that	SCONJ
biomedich-902	129	8	there	there	PRON
biomedich-902	129	9	are	be	VERB
biomedich-902	129	10	no	no	DET
biomedich-902	129	11	competing	compete	VERB
biomedich-902	129	12	interests	interest	NOUN
biomedich-902	129	13	.	.	PUNCT
biomedich-902	130	1	funding	funding	NOUN
biomedich-902	130	2	:	:	PUNCT
biomedich-902	130	3	funding	funding	NOUN
biomedich-902	130	4	was	be	AUX
biomedich-902	130	5	not	not	PART
biomedich-902	130	6	requested	request	VERB
biomedich-902	130	7	.	.	PUNCT
biomedich-902	131	1	references	reference	NOUN
biomedich-902	131	2	denzel	denzel	PROPN
biomedich-902	131	3	,	,	PUNCT
biomedich-902	131	4	a.	a.	PROPN
biomedich-902	131	5	,	,	PUNCT
biomedich-902	131	6	&	&	CCONJ
biomedich-902	131	7	kästner	kästner	PROPN
biomedich-902	131	8	,	,	PUNCT
biomedich-902	131	9	j.	j.	PROPN
biomedich-902	131	10	(	(	PUNCT
biomedich-902	131	11	2018	2018	NUM
biomedich-902	131	12	)	)	PUNCT
biomedich-902	131	13	.	.	PUNCT
biomedich-902	132	1	gaussian	gaussian	ADJ
biomedich-902	132	2	process	process	NOUN
biomedich-902	132	3	regression	regression	NOUN
biomedich-902	132	4	for	for	ADP
biomedich-902	132	5	geometry	geometry	NOUN
biomedich-902	132	6	optimization	optimization	NOUN
biomedich-902	132	7	.	.	PUNCT
biomedich-902	133	1	journal	journal	PROPN
biomedich-902	133	2	of	of	ADP
biomedich-902	133	3	chemical	chemical	PROPN
biomedich-902	133	4	physics	physics	PROPN
biomedich-902	133	5	,	,	PUNCT
biomedich-902	133	6	148(9	148(9	NUM
biomedich-902	133	7	)	)	PUNCT
biomedich-902	133	8	,	,	PUNCT
biomedich-902	133	9	1–24	1–24	PROPN
biomedich-902	133	10	.	.	PUNCT
biomedich-902	134	1	https://doi.org/10.1063/1.5017103	https://doi.org/10.1063/1.5017103	PROPN
biomedich-902	135	1	desai	desai	PROPN
biomedich-902	135	2	,	,	PUNCT
biomedich-902	135	3	s.	s.	PROPN
biomedich-902	135	4	,	,	PUNCT
biomedich-902	135	5	&	&	CCONJ
biomedich-902	135	6	tatke	tatke	NOUN
biomedich-902	135	7	,	,	PUNCT
biomedich-902	135	8	p.	p.	NOUN
biomedich-902	135	9	(	(	PUNCT
biomedich-902	135	10	2015	2015	NUM
biomedich-902	135	11	)	)	PUNCT
biomedich-902	135	12	.	.	PUNCT
biomedich-902	136	1	charantin	charantin	PROPN
biomedich-902	136	2	 	 	SPACE
biomedich-902	136	3	:	:	PUNCT
biomedich-902	136	4	an	an	DET
biomedich-902	136	5	important	important	ADJ
biomedich-902	136	6	lead	lead	NOUN
biomedich-902	136	7	compound	compound	NOUN
biomedich-902	136	8	from	from	ADP
biomedich-902	136	9	momordica	momordica	PROPN
biomedich-902	136	10	charantia	charantia	PROPN
biomedich-902	136	11	for	for	ADP
biomedich-902	136	12	the	the	DET
biomedich-902	136	13	treatment	treatment	NOUN
biomedich-902	136	14	of	of	ADP
biomedich-902	136	15	diabetes	diabetes	NOUN
biomedich-902	136	16	.	.	PUNCT
biomedich-902	137	1	3(6	3(6	NUM
biomedich-902	137	2	)	)	PUNCT
biomedich-902	137	3	,	,	PUNCT
biomedich-902	137	4	163–166	163–166	NUM
biomedich-902	137	5	.	.	PUNCT
biomedich-902	137	6	https://doi.org/10.1063/1.5017103	https://doi.org/10.1063/1.5017103	PROPN
biomedich-902	137	7	1110	1110	NUM
biomedich-902	137	8	biology	biology	NOUN
biomedich-902	137	9	,	,	PUNCT
biomedich-902	137	10	medicine	medicine	NOUN
biomedich-902	137	11	,	,	PUNCT
biomedich-902	137	12	&	&	CCONJ
biomedich-902	137	13	natural	natural	ADJ
biomedich-902	137	14	product	product	NOUN
biomedich-902	137	15	chemistry	chemistry	NOUN
biomedich-902	137	16	14	14	NUM
biomedich-902	137	17	(	(	PUNCT
biomedich-902	137	18	2	2	NUM
biomedich-902	137	19	)	)	PUNCT
biomedich-902	137	20	,	,	PUNCT
biomedich-902	137	21	2025	2025	NUM
biomedich-902	137	22	:	:	PUNCT
biomedich-902	137	23	1105	1105	NUM
biomedich-902	137	24	-	-	SYM
biomedich-902	137	25	1110	1110	NUM
biomedich-902	137	26	hase	hase	NOUN
biomedich-902	137	27	,	,	PUNCT
biomedich-902	137	28	w.	w.	PROPN
biomedich-902	137	29	l.	l.	PROPN
biomedich-902	137	30	,	,	PUNCT
biomedich-902	137	31	&	&	CCONJ
biomedich-902	137	32	scuseria	scuseria	PROPN
biomedich-902	137	33	,	,	PUNCT
biomedich-902	137	34	g.	g.	PROPN
biomedich-902	137	35	e.	e.	PROPN
biomedich-902	137	36	(	(	PUNCT
biomedich-902	137	37	2003	2003	NUM
biomedich-902	137	38	)	)	PUNCT
biomedich-902	137	39	.	.	PUNCT
biomedich-902	138	1	computational	computational	ADJ
biomedich-902	138	2	chemistry	chemistry	NOUN
biomedich-902	138	3	.	.	PUNCT
biomedich-902	139	1	in	in	ADP
biomedich-902	139	2	computing	compute	VERB
biomedich-902	139	3	in	in	ADP
biomedich-902	139	4	science	science	NOUN
biomedich-902	139	5	and	and	CCONJ
biomedich-902	139	6	engineering	engineering	NOUN
biomedich-902	139	7	(	(	PUNCT
biomedich-902	139	8	vol	vol	NOUN
biomedich-902	139	9	.	.	PROPN
biomedich-902	139	10	5	5	NUM
biomedich-902	139	11	,	,	PUNCT
biomedich-902	139	12	issue	issue	NOUN
biomedich-902	139	13	4	4	NUM
biomedich-902	139	14	)	)	PUNCT
biomedich-902	139	15	.	.	PUNCT
biomedich-902	140	1	https://doi.org/10.1109/mcise.2003.1208636	https://doi.org/10.1109/mcise.2003.1208636	NOUN
biomedich-902	140	2	hazarika	hazarika	NOUN
biomedich-902	140	3	,	,	PUNCT
biomedich-902	140	4	r.	r.	PROPN
biomedich-902	140	5	,	,	PUNCT
biomedich-902	140	6	parida	parida	PROPN
biomedich-902	140	7	,	,	PUNCT
biomedich-902	140	8	p.	p.	NOUN
biomedich-902	140	9	,	,	PUNCT
biomedich-902	140	10	neog	neog	NOUN
biomedich-902	140	11	,	,	PUNCT
biomedich-902	140	12	b.	b.	PROPN
biomedich-902	140	13	,	,	PUNCT
biomedich-902	140	14	&	&	CCONJ
biomedich-902	140	15	yadav	yadav	PROPN
biomedich-902	140	16	,	,	PUNCT
biomedich-902	140	17	r.	r.	PROPN
biomedich-902	140	18	(	(	PUNCT
biomedich-902	140	19	2012	2012	NUM
biomedich-902	140	20	)	)	PUNCT
biomedich-902	140	21	.	.	PUNCT
biomedich-902	141	1	binding	bind	VERB
biomedich-902	141	2	energy	energy	NOUN
biomedich-902	141	3	calculation	calculation	NOUN
biomedich-902	141	4	of	of	ADP
biomedich-902	141	5	gsk-3	gsk-3	PUNCT
biomedich-902	141	6	protein	protein	NOUN
biomedich-902	141	7	of	of	ADP
biomedich-902	141	8	human	human	NOUN
biomedich-902	141	9	against	against	ADP
biomedich-902	141	10	some	some	DET
biomedich-902	141	11	anti	anti	ADJ
biomedich-902	141	12	-	-	ADJ
biomedich-902	141	13	diabetic	diabetic	ADJ
biomedich-902	141	14	compounds	compound	NOUN
biomedich-902	141	15	of	of	ADP
biomedich-902	141	16	momordica	momordica	PROPN
biomedich-902	141	17	charantia	charantia	PROPN
biomedich-902	141	18	linn	linn	PROPN
biomedich-902	141	19	(	(	PUNCT
biomedich-902	141	20	bitter	bitter	ADJ
biomedich-902	141	21	melon	melon	NOUN
biomedich-902	141	22	)	)	PUNCT
biomedich-902	141	23	.	.	PUNCT
biomedich-902	142	1	bioinformation	bioinformation	NOUN
biomedich-902	142	2	,	,	PUNCT
biomedich-902	142	3	8(6	8(6	NUM
biomedich-902	142	4	)	)	PUNCT
biomedich-902	142	5	,	,	PUNCT
biomedich-902	142	6	251–254	251–254	NUM
biomedich-902	142	7	.	.	PUNCT
biomedich-902	143	1	https://doi.org/10.6026/97320630008251	https://doi.org/10.6026/97320630008251	PROPN
biomedich-902	143	2	joseph	joseph	PROPN
biomedich-902	143	3	,	,	PUNCT
biomedich-902	143	4	b.	b.	PROPN
biomedich-902	143	5	,	,	PUNCT
biomedich-902	143	6	&	&	CCONJ
biomedich-902	143	7	jini	jini	PROPN
biomedich-902	143	8	,	,	PUNCT
biomedich-902	143	9	d.	d.	PROPN
biomedich-902	143	10	(	(	PUNCT
biomedich-902	143	11	2013	2013	NUM
biomedich-902	143	12	)	)	PUNCT
biomedich-902	143	13	.	.	PUNCT
biomedich-902	144	1	antidiabetic	antidiabetic	ADJ
biomedich-902	144	2	effects	effect	NOUN
biomedich-902	144	3	of	of	ADP
biomedich-902	144	4	momordica	momordica	PROPN
biomedich-902	144	5	charantia	charantia	PROPN
biomedich-902	144	6	(	(	PUNCT
biomedich-902	144	7	bitter	bitter	ADJ
biomedich-902	144	8	melon	melon	NOUN
biomedich-902	144	9	)	)	PUNCT
biomedich-902	144	10	and	and	CCONJ
biomedich-902	144	11	its	its	PRON
biomedich-902	144	12	medicinal	medicinal	ADJ
biomedich-902	144	13	potency	potency	NOUN
biomedich-902	144	14	.	.	PUNCT
biomedich-902	145	1	asian	asian	PROPN
biomedich-902	145	2	pacific	pacific	PROPN
biomedich-902	145	3	journal	journal	PROPN
biomedich-902	145	4	of	of	ADP
biomedich-902	145	5	tropical	tropical	ADJ
biomedich-902	145	6	disease	disease	NOUN
biomedich-902	145	7	,	,	PUNCT
biomedich-902	145	8	3(2	3(2	NUM
biomedich-902	145	9	)	)	PUNCT
biomedich-902	145	10	,	,	PUNCT
biomedich-902	146	1	93–102	93–102	NUM
biomedich-902	146	2	.	.	PUNCT
biomedich-902	147	1	https://doi.org/10.1016/s2222-1808(13)60052-3	https://doi.org/10.1016/s2222-1808(13)60052-3	PROPN
biomedich-902	147	2	klein	klein	PROPN
biomedich-902	147	3	,	,	PUNCT
biomedich-902	147	4	e.	e.	PROPN
biomedich-902	147	5	,	,	PUNCT
biomedich-902	147	6	&	&	CCONJ
biomedich-902	147	7	lukeš	lukeš	PROPN
biomedich-902	147	8	,	,	PUNCT
biomedich-902	147	9	v.	v.	PROPN
biomedich-902	147	10	(	(	PUNCT
biomedich-902	147	11	2006	2006	NUM
biomedich-902	147	12	)	)	PUNCT
biomedich-902	147	13	.	.	PUNCT
biomedich-902	148	1	dft	dft	PROPN
biomedich-902	148	2	/	/	SYM
biomedich-902	148	3	b3lyp	b3lyp	PROPN
biomedich-902	148	4	study	study	NOUN
biomedich-902	148	5	of	of	ADP
biomedich-902	148	6	the	the	DET
biomedich-902	148	7	substituent	substituent	NOUN
biomedich-902	148	8	effect	effect	NOUN
biomedich-902	148	9	on	on	ADP
biomedich-902	148	10	the	the	DET
biomedich-902	148	11	reaction	reaction	NOUN
biomedich-902	148	12	enthalpies	enthalpy	NOUN
biomedich-902	148	13	of	of	ADP
biomedich-902	148	14	the	the	DET
biomedich-902	148	15	individual	individual	ADJ
biomedich-902	148	16	steps	step	NOUN
biomedich-902	148	17	of	of	ADP
biomedich-902	148	18	single	single	ADJ
biomedich-902	148	19	electron	electron	NOUN
biomedich-902	148	20	transfer	transfer	NOUN
biomedich-902	148	21	-	-	PUNCT
biomedich-902	148	22	proton	proton	NOUN
biomedich-902	148	23	transfer	transfer	NOUN
biomedich-902	148	24	and	and	CCONJ
biomedich-902	148	25	sequential	sequential	ADJ
biomedich-902	148	26	proton	proton	NOUN
biomedich-902	148	27	loss	loss	NOUN
biomedich-902	148	28	electron	electron	NOUN
biomedich-902	148	29	transfer	transfer	NOUN
biomedich-902	148	30	mechanisms	mechanism	NOUN
biomedich-902	148	31	of	of	ADP
biomedich-902	148	32	phenols	phenol	NOUN
biomedich-902	148	33	antioxidant	antioxidant	ADJ
biomedich-902	148	34	action	action	NOUN
biomedich-902	148	35	.	.	PUNCT
biomedich-902	149	1	journal	journal	PROPN
biomedich-902	149	2	of	of	ADP
biomedich-902	149	3	physical	physical	ADJ
biomedich-902	149	4	chemistry	chemistry	NOUN
biomedich-902	149	5	a	a	PRON
biomedich-902	149	6	,	,	PUNCT
biomedich-902	149	7	110(44	110(44	NUM
biomedich-902	149	8	)	)	PUNCT
biomedich-902	149	9	,	,	PUNCT
biomedich-902	149	10	12312–12320	12312–12320	NUM
biomedich-902	149	11	.	.	PUNCT
biomedich-902	150	1	https://doi.org/10.1021/jp063468i	https://doi.org/10.1021/jp063468i	PROPN
biomedich-902	150	2	liu	liu	PROPN
biomedich-902	150	3	,	,	PUNCT
biomedich-902	150	4	z.	z.	PROPN
biomedich-902	150	5	,	,	PUNCT
biomedich-902	150	6	gong	gong	PROPN
biomedich-902	150	7	,	,	PUNCT
biomedich-902	150	8	j.	j.	PROPN
biomedich-902	150	9	,	,	PUNCT
biomedich-902	150	10	huang	huang	PROPN
biomedich-902	150	11	,	,	PUNCT
biomedich-902	150	12	w.	w.	PROPN
biomedich-902	150	13	,	,	PUNCT
biomedich-902	150	14	lu	lu	PROPN
biomedich-902	150	15	,	,	PUNCT
biomedich-902	150	16	f.	f.	PROPN
biomedich-902	150	17	,	,	PUNCT
biomedich-902	150	18	&	&	CCONJ
biomedich-902	150	19	dong	dong	PROPN
biomedich-902	150	20	,	,	PUNCT
biomedich-902	150	21	h.	h.	PROPN
biomedich-902	150	22	(	(	PUNCT
biomedich-902	150	23	2021	2021	NUM
biomedich-902	150	24	)	)	PUNCT
biomedich-902	150	25	.	.	PUNCT
biomedich-902	151	1	the	the	DET
biomedich-902	151	2	effect	effect	NOUN
biomedich-902	151	3	of	of	ADP
biomedich-902	151	4	momordica	momordica	PROPN
biomedich-902	151	5	charantia	charantia	PROPN
biomedich-902	151	6	in	in	ADP
biomedich-902	151	7	the	the	DET
biomedich-902	151	8	treatment	treatment	NOUN
biomedich-902	151	9	of	of	ADP
biomedich-902	151	10	diabetes	diabetes	NOUN
biomedich-902	151	11	mellitus	mellitus	NOUN
biomedich-902	151	12	:	:	PUNCT
biomedich-902	151	13	a	a	DET
biomedich-902	151	14	review	review	NOUN
biomedich-902	151	15	.	.	PUNCT
biomedich-902	152	1	evidence	evidence	NOUN
biomedich-902	152	2	-	-	PUNCT
biomedich-902	152	3	based	base	VERB
biomedich-902	152	4	complementary	complementary	ADJ
biomedich-902	152	5	and	and	CCONJ
biomedich-902	152	6	alternative	alternative	ADJ
biomedich-902	152	7	medicine	medicine	NOUN
biomedich-902	152	8	,	,	PUNCT
biomedich-902	152	9	2021	2021	NUM
biomedich-902	152	10	.	.	PUNCT
biomedich-902	153	1	https://doi.org/10.1155/2021/3796265	https://doi.org/10.1155/2021/3796265	PROPN
biomedich-902	153	2	pandey	pandey	PROPN
biomedich-902	153	3	,	,	PUNCT
biomedich-902	153	4	m.	m.	PROPN
biomedich-902	153	5	k.	k.	PROPN
biomedich-902	153	6	,	,	PUNCT
biomedich-902	153	7	&	&	CCONJ
biomedich-902	153	8	degrado	degrado	PROPN
biomedich-902	153	9	,	,	PUNCT
biomedich-902	153	10	t.	t.	PROPN
biomedich-902	153	11	r.	r.	PROPN
biomedich-902	153	12	(	(	PUNCT
biomedich-902	153	13	2016	2016	NUM
biomedich-902	153	14	)	)	PUNCT
biomedich-902	153	15	.	.	PUNCT
biomedich-902	154	1	glycogen	glycogen	NOUN
biomedich-902	154	2	synthase	synthase	NOUN
biomedich-902	154	3	kinase-3	kinase-3	PROPN
biomedich-902	154	4	(	(	PUNCT
biomedich-902	154	5	gsk-3)-targeted	gsk-3)-targete	VERB
biomedich-902	154	6	therapy	therapy	NOUN
biomedich-902	154	7	and	and	CCONJ
biomedich-902	154	8	imaging	imaging	NOUN
biomedich-902	154	9	.	.	PUNCT
biomedich-902	155	1	theranostics	theranostic	NOUN
biomedich-902	155	2	,	,	PUNCT
biomedich-902	155	3	6(4	6(4	NOUN
biomedich-902	155	4	)	)	PUNCT
biomedich-902	155	5	,	,	PUNCT
biomedich-902	155	6	571–593	571–593	NUM
biomedich-902	155	7	.	.	PUNCT
biomedich-902	155	8	https://doi.org/10.7150/thno.14334	https://doi.org/10.7150/thno.14334	NOUN
biomedich-902	155	9	prasangika	prasangika	NOUN
biomedich-902	155	10	,	,	PUNCT
biomedich-902	155	11	f.	f.	PROPN
biomedich-902	155	12	n.	n.	PROPN
biomedich-902	155	13	,	,	PUNCT
biomedich-902	155	14	jayawardana	jayawardana	PROPN
biomedich-902	155	15	,	,	PUNCT
biomedich-902	155	16	s.	s.	PROPN
biomedich-902	155	17	b.	b.	PROPN
biomedich-902	155	18	,	,	PUNCT
biomedich-902	155	19	rajapaksha	rajapaksha	PROPN
biomedich-902	155	20	,	,	PUNCT
biomedich-902	155	21	h.	h.	PROPN
biomedich-902	155	22	,	,	PUNCT
biomedich-902	155	23	&	&	CCONJ
biomedich-902	155	24	pandithavidana	pandithavidana	PROPN
biomedich-902	155	25	,	,	PUNCT
biomedich-902	155	26	d.	d.	PROPN
biomedich-902	155	27	r.	r.	PROPN
biomedich-902	155	28	(	(	PUNCT
biomedich-902	155	29	2025	2025	NUM
biomedich-902	155	30	)	)	PUNCT
biomedich-902	155	31	.	.	PUNCT
biomedich-902	156	1	comparative	comparative	ADJ
biomedich-902	156	2	computational	computational	ADJ
biomedich-902	156	3	analysis	analysis	NOUN
biomedich-902	156	4	of	of	ADP
biomedich-902	156	5	the	the	DET
biomedich-902	156	6	antidiabetic	antidiabetic	ADJ
biomedich-902	156	7	potential	potential	NOUN
biomedich-902	156	8	of	of	ADP
biomedich-902	156	9	momordenol	momordenol	NOUN
biomedich-902	156	10	,	,	PUNCT
biomedich-902	156	11	momordicilin	momordicilin	PROPN
biomedich-902	156	12	,	,	PUNCT
biomedich-902	156	13	charantin	charantin	NOUN
biomedich-902	156	14	and	and	CCONJ
biomedich-902	156	15	vicine	vicine	NOUN
biomedich-902	156	16	from	from	ADP
biomedich-902	156	17	momordica	momordica	PROPN
biomedich-902	156	18	charantia	charantia	PROPN
biomedich-902	156	19	(	(	PUNCT
biomedich-902	156	20	bitter	bitter	ADJ
biomedich-902	156	21	melon	melon	NOUN
biomedich-902	156	22	)	)	PUNCT
biomedich-902	156	23	comparative	comparative	ADJ
biomedich-902	156	24	computational	computational	ADJ
biomedich-902	156	25	analysis	analysis	NOUN
biomedich-902	156	26	of	of	ADP
biomedich-902	156	27	the	the	DET
biomedich-902	156	28	antidiabetic	antidiabetic	ADJ
biomedich-902	156	29	potential	potential	NOUN
biomedich-902	156	30	of	of	ADP
biomedich-902	156	31	momordenol	momordenol	NOUN
biomedich-902	156	32	,	,	PUNCT
biomedich-902	156	33	momordicilin	momordicilin	PROPN
biomedich-902	156	34	,	,	PUNCT
biomedich-902	156	35	charantin	charantin	NOUN
biomedich-902	156	36	and	and	CCONJ
biomedich-902	156	37	vicine	vicine	NOUN
biomedich-902	156	38	from	from	ADP
biomedich-902	156	39	momordica	momordica	PROPN
biomedich-902	156	40	charantia	charantia	PROPN
biomedich-902	156	41	(	(	PUNCT
biomedich-902	156	42	bitter	bitter	ADJ
biomedich-902	156	43	melon	melon	NOUN
biomedich-902	156	44	)	)	PUNCT
biomedich-902	156	45	.	.	PUNCT
biomedich-902	157	1	54(3	54(3	NUM
biomedich-902	157	2	)	)	PUNCT
biomedich-902	157	3	,	,	PUNCT
biomedich-902	157	4	835–843	835–843	NUM
biomedich-902	157	5	.	.	PUNCT
biomedich-902	158	1	https://doi.org/10.4038/cjs.v54i3.8728	https://doi.org/10.4038/cjs.v54i3.8728	PROPN
biomedich-902	158	2	schlegel	schlegel	PROPN
biomedich-902	158	3	,	,	PUNCT
biomedich-902	158	4	h.	h.	PROPN
biomedich-902	158	5	b.	b.	PROPN
biomedich-902	158	6	(	(	PUNCT
biomedich-902	158	7	2011	2011	NUM
biomedich-902	158	8	)	)	PUNCT
biomedich-902	158	9	.	.	PUNCT
biomedich-902	159	1	geometry	geometry	NOUN
biomedich-902	159	2	optimization	optimization	NOUN
biomedich-902	159	3	.	.	PUNCT
biomedich-902	160	1	wiley	wiley	PROPN
biomedich-902	160	2	interdisciplinary	interdisciplinary	ADJ
biomedich-902	160	3	reviews	review	NOUN
biomedich-902	160	4	:	:	PUNCT
biomedich-902	160	5	computational	computational	ADJ
biomedich-902	160	6	molecular	molecular	ADJ
biomedich-902	160	7	science	science	NOUN
biomedich-902	160	8	,	,	PUNCT
biomedich-902	160	9	1(5	1(5	NUM
biomedich-902	160	10	)	)	PUNCT
biomedich-902	160	11	,	,	PUNCT
biomedich-902	160	12	790–809	790–809	NUM
biomedich-902	160	13	.	.	PUNCT
biomedich-902	161	1	https://doi.org/10.1002/wcms.34	https://doi.org/10.1002/wcms.34	PROPN
biomedich-902	161	2	sneha	sneha	PROPN
biomedich-902	161	3	,	,	PUNCT
biomedich-902	161	4	m.	m.	NOUN
biomedich-902	161	5	,	,	PUNCT
biomedich-902	161	6	sartape	sartape	NOUN
biomedich-902	161	7	,	,	PUNCT
biomedich-902	161	8	m.	m.	NOUN
biomedich-902	161	9	s.	s.	PROPN
biomedich-902	161	10	,	,	PUNCT
biomedich-902	161	11	&	&	CCONJ
biomedich-902	161	12	nikita	nikita	PROPN
biomedich-902	161	13	,	,	PUNCT
biomedich-902	161	14	m.	m.	NOUN
biomedich-902	161	15	s.	s.	PROPN
biomedich-902	161	16	(	(	PUNCT
biomedich-902	161	17	2023	2023	NUM
biomedich-902	161	18	)	)	PUNCT
biomedich-902	161	19	.	.	PUNCT
biomedich-902	162	1	anti	anti	ADJ
biomedich-902	162	2	-	-	ADJ
biomedich-902	162	3	diabetic	diabetic	ADJ
biomedich-902	162	4	effects	effect	NOUN
biomedich-902	162	5	of	of	ADP
biomedich-902	162	6	bitter	bitter	ADJ
biomedich-902	162	7	melon	melon	NOUN
biomedich-902	162	8	(	(	PUNCT
biomedich-902	162	9	momordica	momordica	PROPN
biomedich-902	162	10	charantia	charantia	PROPN
biomedich-902	162	11	):	):	PUNCT
biomedich-902	162	12	a	a	DET
biomedich-902	162	13	review	review	NOUN
biomedich-902	162	14	.	.	PUNCT
biomedich-902	163	1	8(12	8(12	NUM
biomedich-902	163	2	)	)	PUNCT
biomedich-902	163	3	,	,	PUNCT
biomedich-902	163	4	864–878	864–878	NUM
biomedich-902	163	5	.	.	PUNCT
biomedich-902	164	1	ullah	ullah	PROPN
biomedich-902	164	2	,	,	PUNCT
biomedich-902	164	3	a.	a.	PROPN
biomedich-902	164	4	,	,	PUNCT
biomedich-902	164	5	ali	ali	PROPN
biomedich-902	164	6	,	,	PUNCT
biomedich-902	164	7	n.	n.	PROPN
biomedich-902	164	8	,	,	PUNCT
biomedich-902	164	9	ahmad	ahmad	PROPN
biomedich-902	164	10	,	,	PUNCT
biomedich-902	164	11	s.	s.	PROPN
biomedich-902	164	12	,	,	PUNCT
biomedich-902	164	13	rahman	rahman	PROPN
biomedich-902	164	14	,	,	PUNCT
biomedich-902	164	15	s.	s.	PROPN
biomedich-902	164	16	u.	u.	PROPN
biomedich-902	164	17	,	,	PUNCT
biomedich-902	164	18	alghamdi	alghamdi	PROPN
biomedich-902	164	19	,	,	PUNCT
biomedich-902	164	20	s.	s.	PROPN
biomedich-902	164	21	,	,	PUNCT
biomedich-902	164	22	bannunah	bannunah	PROPN
biomedich-902	164	23	,	,	PUNCT
biomedich-902	164	24	a.	a.	NOUN
biomedich-902	164	25	m.	m.	NOUN
biomedich-902	164	26	,	,	PUNCT
biomedich-902	164	27	ali	ali	PROPN
biomedich-902	164	28	,	,	PUNCT
biomedich-902	164	29	r.	r.	PROPN
biomedich-902	164	30	,	,	PUNCT
biomedich-902	164	31	aman	aman	PROPN
biomedich-902	164	32	,	,	PUNCT
biomedich-902	164	33	a.	a.	PROPN
biomedich-902	164	34	,	,	PUNCT
biomedich-902	164	35	khan	khan	PROPN
biomedich-902	164	36	,	,	PUNCT
biomedich-902	164	37	j.	j.	PROPN
biomedich-902	164	38	,	,	PUNCT
biomedich-902	164	39	hussain	hussain	PROPN
biomedich-902	164	40	,	,	PUNCT
biomedich-902	164	41	h.	h.	PROPN
biomedich-902	164	42	,	,	PUNCT
biomedich-902	164	43	&	&	CCONJ
biomedich-902	164	44	sahibzada	sahibzada	PROPN
biomedich-902	164	45	,	,	PUNCT
biomedich-902	164	46	m.	m.	NOUN
biomedich-902	164	47	u.	u.	PROPN
biomedich-902	164	48	k.	k.	PROPN
biomedich-902	164	49	(	(	PUNCT
biomedich-902	164	50	2023	2023	NUM
biomedich-902	164	51	)	)	PUNCT
biomedich-902	164	52	.	.	PUNCT
biomedich-902	165	1	glycogen	glycogen	NOUN
biomedich-902	165	2	synthase	synthase	NOUN
biomedich-902	165	3	kinase-3	kinase-3	PROPN
biomedich-902	165	4	(	(	PUNCT
biomedich-902	165	5	gsk-3	gsk-3	NOUN
biomedich-902	165	6	)	)	PUNCT
biomedich-902	165	7	a	a	DET
biomedich-902	165	8	magic	magic	ADJ
biomedich-902	165	9	enzyme	enzyme	NOUN
biomedich-902	165	10	:	:	PUNCT
biomedich-902	165	11	it	it	PRON
biomedich-902	165	12	’s	’	VERB
biomedich-902	165	13	role	role	NOUN
biomedich-902	165	14	in	in	ADP
biomedich-902	165	15	diabetes	diabetes	NOUN
biomedich-902	165	16	mellitus	mellitus	NOUN
biomedich-902	165	17	and	and	CCONJ
biomedich-902	165	18	glucose	glucose	NOUN
biomedich-902	165	19	homeostasis	homeostasis	NOUN
biomedich-902	165	20	,	,	PUNCT
biomedich-902	165	21	interactions	interaction	NOUN
biomedich-902	165	22	with	with	ADP
biomedich-902	165	23	fluroquionlones	fluroquionlone	NOUN
biomedich-902	165	24	.	.	PUNCT
biomedich-902	166	1	a	a	DET
biomedich-902	166	2	mini	mini	NOUN
biomedich-902	166	3	-	-	NOUN
biomedich-902	166	4	review	review	NOUN
biomedich-902	166	5	.	.	PUNCT
biomedich-902	167	1	brazilian	brazilian	ADJ
biomedich-902	167	2	journal	journal	PROPN
biomedich-902	167	3	of	of	ADP
biomedich-902	167	4	biology	biology	NOUN
biomedich-902	167	5	,	,	PUNCT
biomedich-902	167	6	83	83	NUM
biomedich-902	167	7	,	,	PUNCT
biomedich-902	167	8	1–5	1–5	NUM
biomedich-902	167	9	.	.	PUNCT
biomedich-902	167	10	https://doi.org/10.1590/1519-6984.250179	https://doi.org/10.1590/1519-6984.250179	PROPN
biomedich-902	167	11	varma	varma	PROPN
biomedich-902	167	12	narasimha	narasimha	PROPN
biomedich-902	167	13	k.	k.	PROPN
biomedich-902	167	14	(	(	PUNCT
biomedich-902	167	15	2022	2022	NUM
biomedich-902	167	16	)	)	PUNCT
biomedich-902	167	17	.	.	PUNCT
biomedich-902	168	1	momordica	momordica	PROPN
biomedich-902	168	2	charantia	charantia	PROPN
biomedich-902	168	3	:	:	PUNCT
biomedich-902	168	4	a	a	DET
biomedich-902	168	5	potential	potential	ADJ
biomedich-902	168	6	source	source	NOUN
biomedich-902	168	7	for	for	ADP
biomedich-902	168	8	treating	treat	VERB
biomedich-902	168	9	diabetes	diabetes	NOUN
biomedich-902	168	10	mellitus	mellitus	NOUN
biomedich-902	168	11	:	:	PUNCT
biomedich-902	168	12	a	a	DET
biomedich-902	168	13	review	review	NOUN
biomedich-902	168	14	.	.	PUNCT
biomedich-902	169	1	international	international	ADJ
biomedich-902	169	2	journal	journal	PROPN
biomedich-902	169	3	of	of	ADP
biomedich-902	169	4	creative	creative	ADJ
biomedich-902	169	5	research	research	NOUN
biomedich-902	169	6	thoughts	thought	NOUN
biomedich-902	169	7	,	,	PUNCT
biomedich-902	169	8	10(8	10(8	NUM
biomedich-902	169	9	august	august	PROPN
biomedich-902	169	10	2022	2022	NUM
biomedich-902	169	11	)	)	PUNCT
biomedich-902	169	12	,	,	PUNCT
biomedich-902	169	13	548–558	548–558	NUM
biomedich-902	169	14	.	.	PUNCT
biomedich-902	170	1	zahid	zahid	PROPN
biomedich-902	170	2	,	,	PUNCT
biomedich-902	170	3	a.	a.	PROPN
biomedich-902	170	4	,	,	PUNCT
biomedich-902	170	5	fozia	fozia	PROPN
biomedich-902	170	6	,	,	PUNCT
biomedich-902	170	7	m.	m.	NOUN
biomedich-902	170	8	r.	r.	PROPN
biomedich-902	170	9	,	,	PUNCT
biomedich-902	170	10	&	&	CCONJ
biomedich-902	170	11	ahmed	ahmed	PROPN
biomedich-902	170	12	,	,	PUNCT
biomedich-902	170	13	s.	s.	PROPN
biomedich-902	170	14	(	(	PUNCT
biomedich-902	170	15	2019	2019	NUM
biomedich-902	170	16	)	)	PUNCT
biomedich-902	170	17	.	.	PUNCT
biomedich-902	171	1	bitter	bitter	ADJ
biomedich-902	171	2	gourd	gourd	NOUN
biomedich-902	171	3	as	as	ADP
biomedich-902	171	4	the	the	DET
biomedich-902	171	5	potential	potential	ADJ
biomedich-902	171	6	source	source	NOUN
biomedich-902	171	7	of	of	ADP
biomedich-902	171	8	various	various	ADJ
biomedich-902	171	9	bioactive	bioactive	ADJ
biomedich-902	171	10	compounds	compound	NOUN
biomedich-902	171	11	and	and	CCONJ
biomedich-902	171	12	its	its	PRON
biomedich-902	171	13	use	use	NOUN
biomedich-902	171	14	for	for	ADP
biomedich-902	171	15	different	different	ADJ
biomedich-902	171	16	diseases	disease	NOUN
biomedich-902	171	17	:	:	PUNCT
biomedich-902	171	18	a	a	DET
biomedich-902	171	19	review	review	NOUN
biomedich-902	171	20	.	.	PUNCT
biomedich-902	172	1	science	science	NOUN
biomedich-902	172	2	letters	letter	NOUN
biomedich-902	172	3	,	,	PUNCT
biomedich-902	172	4	7(3	7(3	NUM
biomedich-902	172	5	)	)	PUNCT
biomedich-902	172	6	,	,	PUNCT
biomedich-902	172	7	99	99	NUM
biomedich-902	172	8	–	–	PUNCT
biomedich-902	172	9	103	103	NUM
biomedich-902	172	10	.	.	PUNCT
biomedich-902	173	1	https://doi.org/10.1109/mcise.2003.1208636	https://doi.org/10.1109/mcise.2003.1208636	PROPN
biomedich-902	173	2	https://doi.org/10.6026/97320630008251	https://doi.org/10.6026/97320630008251	NOUN
biomedich-902	173	3	https://doi.org/10.1016/s2222-1808(13)60052-3	https://doi.org/10.1016/s2222-1808(13)60052-3	VERB
biomedich-902	173	4	https://doi.org/10.1021/jp063468i	https://doi.org/10.1021/jp063468i	ADJ
biomedich-902	173	5	https://doi.org/10.1155/2021/3796265	https://doi.org/10.1155/2021/3796265	PROPN
biomedich-902	173	6	https://doi.org/10.7150/thno.14334	https://doi.org/10.7150/thno.14334	ADJ
biomedich-902	173	7	https://doi.org/10.4038/cjs.v54i3.8728	https://doi.org/10.4038/cjs.v54i3.8728	NOUN
biomedich-902	173	8	https://doi.org/10.1002/wcms.34	https://doi.org/10.1002/wcms.34	NOUN
biomedich-902	173	9	https://doi.org/10.1590/1519-6984.250179	https://doi.org/10.1590/1519-6984.250179	VERB