id	sid	tid	token	lemma	pos
biomedich-91	1	1	biology	biology	NOUN
biomedich-91	1	2	,	,	PUNCT
biomedich-91	1	3	medicine	medicine	NOUN
biomedich-91	1	4	,	,	PUNCT
biomedich-91	1	5	&	&	CCONJ
biomedich-91	1	6	natural	natural	ADJ
biomedich-91	1	7	product	product	NOUN
biomedich-91	1	8	chemistry	chemistry	NOUN
biomedich-91	1	9	issn	issn	VERB
biomedich-91	1	10	2089	2089	NUM
biomedich-91	1	11	-	-	SYM
biomedich-91	1	12	6514	6514	NUM
biomedich-91	1	13	(	(	PUNCT
biomedich-91	1	14	paper	paper	NOUN
biomedich-91	1	15	)	)	PUNCT
biomedich-91	1	16	volume	volume	NOUN
biomedich-91	1	17	8	8	NUM
biomedich-91	1	18	,	,	PUNCT
biomedich-91	1	19	number	number	NOUN
biomedich-91	1	20	2	2	NUM
biomedich-91	1	21	,	,	PUNCT
biomedich-91	1	22	2019	2019	NUM
biomedich-91	1	23	|	|	ADV
biomedich-91	1	24	pages	page	NOUN
biomedich-91	1	25	:	:	PUNCT
biomedich-91	1	26	41	41	NUM
biomedich-91	1	27	-	-	SYM
biomedich-91	1	28	45	45	NUM
biomedich-91	1	29	|	|	ADV
biomedich-91	1	30	doi	doi	NOUN
biomedich-91	1	31	:	:	PUNCT
biomedich-91	1	32	10.14421	10.14421	NUM
biomedich-91	1	33	/	/	SYM
biomedich-91	1	34	biomedich.2019.82.41	biomedich.2019.82.41	NOUN
biomedich-91	1	35	-	-	PUNCT
biomedich-91	1	36	45	45	NUM
biomedich-91	1	37	issn	issn	PROPN
biomedich-91	1	38	2540	2540	NUM
biomedich-91	1	39	-	-	SYM
biomedich-91	1	40	9328	9328	NUM
biomedich-91	1	41	(	(	PUNCT
biomedich-91	1	42	online	online	ADJ
biomedich-91	1	43	)	)	PUNCT
biomedich-91	1	44	hepatotoxic	hepatotoxic	ADJ
biomedich-91	1	45	assessment	assessment	NOUN
biomedich-91	1	46	of	of	ADP
biomedich-91	1	47	tramadol	tramadol	NOUN
biomedich-91	1	48	-	-	PUNCT
biomedich-91	1	49	diclofenac	diclofenac	NOUN
biomedich-91	1	50	use	use	NOUN
biomedich-91	1	51	:	:	PUNCT
biomedich-91	1	52	a	a	DET
biomedich-91	1	53	study	study	NOUN
biomedich-91	1	54	in	in	ADP
biomedich-91	1	55	a	a	DET
biomedich-91	1	56	rat	rat	NOUN
biomedich-91	1	57	model	model	NOUN
biomedich-91	1	58	elias	elias	PROPN
biomedich-91	1	59	adikwu	adikwu	PROPN
biomedich-91	1	60	*	*	PROPN
biomedich-91	1	61	,	,	PUNCT
biomedich-91	1	62	ebinyo	ebinyo	PROPN
biomedich-91	1	63	clemente	clemente	PROPN
biomedich-91	1	64	nelson	nelson	PROPN
biomedich-91	1	65	department	department	PROPN
biomedich-91	1	66	of	of	ADP
biomedich-91	1	67	pharmacology	pharmacology	NOUN
biomedich-91	1	68	and	and	CCONJ
biomedich-91	1	69	toxicology	toxicology	NOUN
biomedich-91	1	70	,	,	PUNCT
biomedich-91	1	71	faculty	faculty	NOUN
biomedich-91	1	72	of	of	ADP
biomedich-91	1	73	pharmacy	pharmacy	NOUN
biomedich-91	1	74	,	,	PUNCT
biomedich-91	1	75	niger	niger	PROPN
biomedich-91	1	76	delta	delta	PROPN
biomedich-91	1	77	university	university	NOUN
biomedich-91	1	78	,	,	PUNCT
biomedich-91	1	79	bayelsa	bayelsa	NOUN
biomedich-91	1	80	state	state	NOUN
biomedich-91	1	81	,	,	PUNCT
biomedich-91	1	82	nigeria	nigeria	PROPN
biomedich-91	1	83	.	.	PUNCT
biomedich-91	2	1	corresponding	correspond	VERB
biomedich-91	2	2	author	author	NOUN
biomedich-91	2	3	*	*	PUNCT
biomedich-91	2	4	adikwuelias@gmail.com	adikwuelias@gmail.com	X
biomedich-91	3	1	abstract	abstract	ADJ
biomedich-91	3	2	the	the	DET
biomedich-91	3	3	concurrent	concurrent	ADJ
biomedich-91	3	4	use	use	NOUN
biomedich-91	3	5	of	of	ADP
biomedich-91	3	6	tramadol	tramadol	NOUN
biomedich-91	3	7	and	and	CCONJ
biomedich-91	3	8	diclofenac	diclofenac	NOUN
biomedich-91	3	9	may	may	AUX
biomedich-91	3	10	increase	increase	VERB
biomedich-91	3	11	hepatotoxic	hepatotoxic	ADJ
biomedich-91	3	12	risk	risk	NOUN
biomedich-91	3	13	due	due	ADP
biomedich-91	3	14	to	to	ADP
biomedich-91	3	15	their	their	PRON
biomedich-91	3	16	individual	individual	ADJ
biomedich-91	3	17	hepatotoxic	hepatotoxic	NOUN
biomedich-91	3	18	effects	effect	NOUN
biomedich-91	3	19	.	.	PUNCT
biomedich-91	4	1	this	this	DET
biomedich-91	4	2	study	study	NOUN
biomedich-91	4	3	assessed	assess	VERB
biomedich-91	4	4	the	the	DET
biomedich-91	4	5	hepatotoxic	hepatotoxic	ADJ
biomedich-91	4	6	effect	effect	NOUN
biomedich-91	4	7	of	of	ADP
biomedich-91	4	8	tramadol	tramadol	NOUN
biomedich-91	4	9	-	-	PUNCT
biomedich-91	4	10	diclofenac	diclofenac	NOUN
biomedich-91	4	11	administration	administration	NOUN
biomedich-91	4	12	in	in	ADP
biomedich-91	4	13	albino	albino	NOUN
biomedich-91	4	14	rats	rat	NOUN
biomedich-91	4	15	.	.	PUNCT
biomedich-91	5	1	twenty	twenty	NUM
biomedich-91	5	2	-	-	PUNCT
biomedich-91	5	3	four	four	NUM
biomedich-91	5	4	adult	adult	NOUN
biomedich-91	5	5	male	male	NOUN
biomedich-91	5	6	albino	albino	NOUN
biomedich-91	5	7	rats	rat	NOUN
biomedich-91	5	8	(	(	PUNCT
biomedich-91	5	9	200	200	NUM
biomedich-91	5	10	-	-	SYM
biomedich-91	5	11	220	220	NUM
biomedich-91	5	12	g	g	NOUN
biomedich-91	5	13	)	)	PUNCT
biomedich-91	5	14	randomized	randomize	VERB
biomedich-91	5	15	into	into	ADP
biomedich-91	5	16	four	four	NUM
biomedich-91	5	17	groups	group	NOUN
biomedich-91	5	18	were	be	AUX
biomedich-91	5	19	orally	orally	ADV
biomedich-91	5	20	administered	administer	VERB
biomedich-91	5	21	with	with	ADP
biomedich-91	5	22	tramadol	tramadol	NOUN
biomedich-91	5	23	(	(	PUNCT
biomedich-91	5	24	12mg	12mg	ADJ
biomedich-91	5	25	/	/	SYM
biomedich-91	5	26	kg	kg	NOUN
biomedich-91	5	27	/	/	SYM
biomedich-91	5	28	day	day	NOUN
biomedich-91	5	29	)	)	PUNCT
biomedich-91	5	30	,	,	PUNCT
biomedich-91	5	31	diclofenac	diclofenac	NOUN
biomedich-91	5	32	(	(	PUNCT
biomedich-91	5	33	6mg	6mg	ADJ
biomedich-91	5	34	/	/	SYM
biomedich-91	5	35	kg	kg	PROPN
biomedich-91	5	36	/	/	SYM
biomedich-91	5	37	day	day	NOUN
biomedich-91	5	38	)	)	PUNCT
biomedich-91	5	39	and	and	CCONJ
biomedich-91	5	40	tramadol	tramadol	NOUN
biomedich-91	5	41	-	-	PUNCT
biomedich-91	5	42	diclofenac	diclofenac	NOUN
biomedich-91	5	43	for	for	ADP
biomedich-91	5	44	14	14	NUM
biomedich-91	5	45	days	day	NOUN
biomedich-91	5	46	respectively	respectively	ADV
biomedich-91	5	47	.	.	PUNCT
biomedich-91	6	1	the	the	DET
biomedich-91	6	2	rats	rat	NOUN
biomedich-91	6	3	were	be	AUX
biomedich-91	6	4	anesthetized	anesthetize	VERB
biomedich-91	6	5	,	,	PUNCT
biomedich-91	6	6	blood	blood	NOUN
biomedich-91	6	7	samples	sample	NOUN
biomedich-91	6	8	were	be	AUX
biomedich-91	6	9	collected	collect	VERB
biomedich-91	6	10	and	and	CCONJ
biomedich-91	6	11	evaluated	evaluate	VERB
biomedich-91	6	12	for	for	ADP
biomedich-91	6	13	serum	serum	NOUN
biomedich-91	6	14	liver	liver	NOUN
biomedich-91	6	15	function	function	NOUN
biomedich-91	6	16	and	and	CCONJ
biomedich-91	6	17	lipid	lipid	NOUN
biomedich-91	6	18	parameters	parameter	NOUN
biomedich-91	6	19	.	.	PUNCT
biomedich-91	7	1	liver	liver	NOUN
biomedich-91	7	2	samples	sample	NOUN
biomedich-91	7	3	were	be	AUX
biomedich-91	7	4	weighed	weigh	VERB
biomedich-91	7	5	and	and	CCONJ
biomedich-91	7	6	evaluated	evaluate	VERB
biomedich-91	7	7	for	for	ADP
biomedich-91	7	8	biochemical	biochemical	ADJ
biomedich-91	7	9	parameters	parameter	NOUN
biomedich-91	7	10	and	and	CCONJ
biomedich-91	7	11	histology	histology	NOUN
biomedich-91	7	12	.	.	PUNCT
biomedich-91	8	1	the	the	DET
biomedich-91	8	2	effects	effect	NOUN
biomedich-91	8	3	of	of	ADP
biomedich-91	8	4	tramadol	tramadol	NOUN
biomedich-91	8	5	-	-	PUNCT
biomedich-91	8	6	diclofenac	diclofenac	NOUN
biomedich-91	8	7	on	on	ADP
biomedich-91	8	8	the	the	DET
biomedich-91	8	9	body	body	NOUN
biomedich-91	8	10	and	and	CCONJ
biomedich-91	8	11	liver	liver	NOUN
biomedich-91	8	12	weights	weight	NOUN
biomedich-91	8	13	did	do	AUX
biomedich-91	8	14	not	not	PART
biomedich-91	8	15	differ	differ	VERB
biomedich-91	8	16	significantly	significantly	ADV
biomedich-91	8	17	(	(	PUNCT
biomedich-91	8	18	p>0.05	p>0.05	PROPN
biomedich-91	8	19	)	)	PUNCT
biomedich-91	8	20	when	when	SCONJ
biomedich-91	8	21	compared	compare	VERB
biomedich-91	8	22	to	to	ADP
biomedich-91	8	23	control	control	NOUN
biomedich-91	8	24	.	.	PUNCT
biomedich-91	9	1	also	also	ADV
biomedich-91	9	2	,	,	PUNCT
biomedich-91	9	3	effects	effect	NOUN
biomedich-91	9	4	were	be	AUX
biomedich-91	9	5	not	not	PART
biomedich-91	9	6	significant	significant	ADJ
biomedich-91	9	7	(	(	PUNCT
biomedich-91	9	8	p>0.05	p>0.05	NOUN
biomedich-91	9	9	)	)	PUNCT
biomedich-91	9	10	on	on	ADP
biomedich-91	9	11	blood	blood	NOUN
biomedich-91	9	12	glucose	glucose	NOUN
biomedich-91	9	13	,	,	PUNCT
biomedich-91	9	14	and	and	CCONJ
biomedich-91	9	15	serum	serum	NOUN
biomedich-91	9	16	cholesterol	cholesterol	NOUN
biomedich-91	9	17	,	,	PUNCT
biomedich-91	9	18	triglyceride	triglyceride	ADJ
biomedich-91	9	19	,	,	PUNCT
biomedich-91	9	20	low	low	ADJ
biomedich-91	9	21	and	and	CCONJ
biomedich-91	9	22	high	high	ADJ
biomedich-91	9	23	density	density	NOUN
biomedich-91	9	24	lipoprotein	lipoprotein	ADJ
biomedich-91	9	25	cholesterol	cholesterol	NOUN
biomedich-91	9	26	levels	level	NOUN
biomedich-91	9	27	when	when	SCONJ
biomedich-91	9	28	compared	compare	VERB
biomedich-91	9	29	to	to	ADP
biomedich-91	9	30	control	control	NOUN
biomedich-91	9	31	.	.	PUNCT
biomedich-91	10	1	liver	liver	NOUN
biomedich-91	10	2	and	and	CCONJ
biomedich-91	10	3	serum	serum	NOUN
biomedich-91	10	4	levels	level	NOUN
biomedich-91	10	5	of	of	ADP
biomedich-91	10	6	aminotransferases	aminotransferase	NOUN
biomedich-91	10	7	,	,	PUNCT
biomedich-91	10	8	alkaline	alkaline	NOUN
biomedich-91	10	9	phosphatase	phosphatase	NOUN
biomedich-91	10	10	,	,	PUNCT
biomedich-91	10	11	lactate	lactate	NOUN
biomedich-91	10	12	dehydrogenase	dehydrogenase	NOUN
biomedich-91	10	13	,	,	PUNCT
biomedich-91	10	14	gamma	gamma	NOUN
biomedich-91	10	15	–	–	PUNCT
biomedich-91	10	16	glutamyl	glutamyl	VERB
biomedich-91	10	17	transferase	transferase	NOUN
biomedich-91	10	18	,	,	PUNCT
biomedich-91	10	19	conjugated	conjugate	VERB
biomedich-91	10	20	bilirubin	bilirubin	NOUN
biomedich-91	10	21	and	and	CCONJ
biomedich-91	10	22	total	total	ADJ
biomedich-91	10	23	bilirubin	bilirubin	NOUN
biomedich-91	10	24	increased	increase	VERB
biomedich-91	10	25	significantly	significantly	ADV
biomedich-91	10	26	in	in	ADP
biomedich-91	10	27	rats	rat	NOUN
biomedich-91	10	28	treated	treat	VERB
biomedich-91	10	29	with	with	ADP
biomedich-91	10	30	tramadol	tramadol	NOUN
biomedich-91	10	31	(	(	PUNCT
biomedich-91	10	32	p<0.05	p<0.05	NOUN
biomedich-91	10	33	)	)	PUNCT
biomedich-91	10	34	,	,	PUNCT
biomedich-91	10	35	diclofenac	diclofenac	NOUN
biomedich-91	10	36	(	(	PUNCT
biomedich-91	10	37	p<0.01	p<0.01	PROPN
biomedich-91	10	38	)	)	PUNCT
biomedich-91	10	39	and	and	CCONJ
biomedich-91	10	40	tramadol	tramadol	NOUN
biomedich-91	10	41	-	-	PUNCT
biomedich-91	10	42	diclofenac	diclofenac	NOUN
biomedich-91	10	43	(	(	PUNCT
biomedich-91	10	44	p<0.001	p<0.001	PROPN
biomedich-91	10	45	)	)	PUNCT
biomedich-91	10	46	when	when	SCONJ
biomedich-91	10	47	compared	compare	VERB
biomedich-91	10	48	to	to	ADP
biomedich-91	10	49	control	control	VERB
biomedich-91	10	50	.	.	PUNCT
biomedich-91	11	1	furthermore	furthermore	ADV
biomedich-91	11	2	,	,	PUNCT
biomedich-91	11	3	significant	significant	ADJ
biomedich-91	11	4	decreases	decrease	NOUN
biomedich-91	11	5	in	in	ADP
biomedich-91	11	6	liver	liver	NOUN
biomedich-91	11	7	catalase	catalase	NOUN
biomedich-91	11	8	,	,	PUNCT
biomedich-91	11	9	glutathione	glutathione	NOUN
biomedich-91	11	10	,	,	PUNCT
biomedich-91	11	11	superoxide	superoxide	NOUN
biomedich-91	11	12	dismutase	dismutase	NOUN
biomedich-91	11	13	,	,	PUNCT
biomedich-91	11	14	glutathione	glutathione	NOUN
biomedich-91	11	15	peroxidase	peroxidase	NOUN
biomedich-91	11	16	levels	level	NOUN
biomedich-91	11	17	with	with	ADP
biomedich-91	11	18	significant	significant	ADJ
biomedich-91	11	19	increases	increase	NOUN
biomedich-91	11	20	in	in	ADP
biomedich-91	11	21	malondialdehyde	malondialdehyde	NOUN
biomedich-91	11	22	levels	level	NOUN
biomedich-91	11	23	occurred	occur	VERB
biomedich-91	11	24	in	in	ADP
biomedich-91	11	25	rats	rat	NOUN
biomedich-91	11	26	treated	treat	VERB
biomedich-91	11	27	with	with	ADP
biomedich-91	11	28	tramadol	tramadol	NOUN
biomedich-91	11	29	(	(	PUNCT
biomedich-91	11	30	p<0.05	p<0.05	NOUN
biomedich-91	11	31	)	)	PUNCT
biomedich-91	11	32	,	,	PUNCT
biomedich-91	11	33	diclofenac	diclofenac	NOUN
biomedich-91	11	34	(	(	PUNCT
biomedich-91	11	35	p<0.01	p<0.01	PROPN
biomedich-91	11	36	)	)	PUNCT
biomedich-91	11	37	and	and	CCONJ
biomedich-91	11	38	tramadol	tramadol	NOUN
biomedich-91	11	39	-	-	PUNCT
biomedich-91	11	40	diclofenac	diclofenac	NOUN
biomedich-91	11	41	(	(	PUNCT
biomedich-91	11	42	p<0.001	p<0.001	PROPN
biomedich-91	11	43	)	)	PUNCT
biomedich-91	11	44	when	when	SCONJ
biomedich-91	11	45	compared	compare	VERB
biomedich-91	11	46	to	to	ADP
biomedich-91	11	47	control	control	NOUN
biomedich-91	11	48	.	.	PUNCT
biomedich-91	12	1	hepatocyte	hepatocyte	NOUN
biomedich-91	12	2	necrosis	necrosis	NOUN
biomedich-91	12	3	was	be	AUX
biomedich-91	12	4	observed	observe	VERB
biomedich-91	12	5	in	in	ADP
biomedich-91	12	6	rats	rat	NOUN
biomedich-91	12	7	treated	treat	VERB
biomedich-91	12	8	with	with	ADP
biomedich-91	12	9	tramadol	tramadol	NOUN
biomedich-91	12	10	-	-	PUNCT
biomedich-91	12	11	diclofenac	diclofenac	NOUN
biomedich-91	12	12	.	.	PUNCT
biomedich-91	13	1	tramadol	tramadol	NOUN
biomedich-91	13	2	-	-	PUNCT
biomedich-91	13	3	diclofenac	diclofenac	NOUN
biomedich-91	13	4	may	may	AUX
biomedich-91	13	5	increase	increase	VERB
biomedich-91	13	6	hepatotoxic	hepatotoxic	ADJ
biomedich-91	13	7	risk	risk	NOUN
biomedich-91	13	8	at	at	ADP
biomedich-91	13	9	doses	dose	NOUN
biomedich-91	13	10	used	use	VERB
biomedich-91	13	11	for	for	ADP
biomedich-91	13	12	this	this	DET
biomedich-91	13	13	study	study	NOUN
biomedich-91	13	14	.	.	PUNCT
biomedich-91	14	1	keywords	keyword	NOUN
biomedich-91	14	2	:	:	PUNCT
biomedich-91	14	3	tramadol	tramadol	NOUN
biomedich-91	14	4	;	;	PUNCT
biomedich-91	14	5	diclofenac	diclofenac	NOUN
biomedich-91	14	6	;	;	PUNCT
biomedich-91	14	7	co	co	NOUN
biomedich-91	14	8	-	-	NOUN
biomedich-91	14	9	treatment	treatment	NOUN
biomedich-91	14	10	;	;	PUNCT
biomedich-91	14	11	toxicity	toxicity	NOUN
biomedich-91	14	12	;	;	PUNCT
biomedich-91	14	13	liver	liver	NOUN
biomedich-91	14	14	;	;	PUNCT
biomedich-91	14	15	rat	rat	NOUN
biomedich-91	14	16	introduction	introduction	NOUN
biomedich-91	14	17	most	most	ADJ
biomedich-91	14	18	medical	medical	ADJ
biomedich-91	14	19	conditions	condition	NOUN
biomedich-91	14	20	are	be	AUX
biomedich-91	14	21	associated	associate	VERB
biomedich-91	14	22	with	with	ADP
biomedich-91	14	23	pain	pain	NOUN
biomedich-91	14	24	.	.	PUNCT
biomedich-91	15	1	pain	pain	NOUN
biomedich-91	15	2	remains	remain	VERB
biomedich-91	15	3	the	the	DET
biomedich-91	15	4	most	most	ADV
biomedich-91	15	5	inadequately	inadequately	ADV
biomedich-91	15	6	treated	treat	VERB
biomedich-91	15	7	symptom	symptom	NOUN
biomedich-91	15	8	due	due	ADP
biomedich-91	15	9	to	to	ADP
biomedich-91	15	10	different	different	ADJ
biomedich-91	15	11	cultural	cultural	ADJ
biomedich-91	15	12	,	,	PUNCT
biomedich-91	15	13	attitudinal	attitudinal	ADJ
biomedich-91	15	14	,	,	PUNCT
biomedich-91	15	15	educational	educational	ADJ
biomedich-91	15	16	,	,	PUNCT
biomedich-91	15	17	legal	legal	ADJ
biomedich-91	15	18	,	,	PUNCT
biomedich-91	15	19	and	and	CCONJ
biomedich-91	15	20	system	system	NOUN
biomedich-91	15	21	-	-	PUNCT
biomedich-91	15	22	related	relate	VERB
biomedich-91	15	23	reasons	reason	NOUN
biomedich-91	15	24	(	(	PUNCT
biomedich-91	15	25	connors	connor	NOUN
biomedich-91	15	26	et	et	NOUN
biomedich-91	15	27	al	al	PROPN
biomedich-91	15	28	.	.	PROPN
biomedich-91	15	29	,	,	PUNCT
biomedich-91	15	30	1995	1995	NUM
biomedich-91	15	31	)	)	PUNCT
biomedich-91	15	32	.	.	PUNCT
biomedich-91	16	1	pain	pain	NOUN
biomedich-91	16	2	has	have	VERB
biomedich-91	16	3	a	a	DET
biomedich-91	16	4	multifactorial	multifactorial	ADJ
biomedich-91	16	5	origin	origin	NOUN
biomedich-91	16	6	;	;	PUNCT
biomedich-91	16	7	hence	hence	ADV
biomedich-91	16	8	it	it	PRON
biomedich-91	16	9	may	may	AUX
biomedich-91	16	10	be	be	AUX
biomedich-91	16	11	difficult	difficult	ADJ
biomedich-91	16	12	to	to	PART
biomedich-91	16	13	achieve	achieve	VERB
biomedich-91	16	14	effective	effective	ADJ
biomedich-91	16	15	pain	pain	NOUN
biomedich-91	16	16	control	control	NOUN
biomedich-91	16	17	with	with	ADP
biomedich-91	16	18	a	a	DET
biomedich-91	16	19	single	single	ADJ
biomedich-91	16	20	drug	drug	NOUN
biomedich-91	16	21	.	.	PUNCT
biomedich-91	17	1	combination	combination	NOUN
biomedich-91	17	2	therapy	therapy	NOUN
biomedich-91	17	3	with	with	ADP
biomedich-91	17	4	analgesics	analgesic	NOUN
biomedich-91	17	5	from	from	ADP
biomedich-91	17	6	different	different	ADJ
biomedich-91	17	7	groups	group	NOUN
biomedich-91	17	8	is	be	AUX
biomedich-91	17	9	advantageous	advantageous	ADJ
biomedich-91	17	10	in	in	ADP
biomedich-91	17	11	targeting	target	VERB
biomedich-91	17	12	both	both	CCONJ
biomedich-91	17	13	peripheral	peripheral	ADJ
biomedich-91	17	14	and	and	CCONJ
biomedich-91	17	15	central	central	ADJ
biomedich-91	17	16	pain	pain	NOUN
biomedich-91	17	17	pathways	pathway	NOUN
biomedich-91	17	18	(	(	PUNCT
biomedich-91	17	19	rawal	rawal	NOUN
biomedich-91	17	20	et	et	NOUN
biomedich-91	17	21	al	al	PROPN
biomedich-91	17	22	.	.	PROPN
biomedich-91	17	23	,	,	PUNCT
biomedich-91	17	24	2011	2011	NUM
biomedich-91	17	25	)	)	PUNCT
biomedich-91	17	26	.	.	PUNCT
biomedich-91	18	1	the	the	DET
biomedich-91	18	2	world	world	PROPN
biomedich-91	18	3	health	health	PROPN
biomedich-91	18	4	organization	organization	NOUN
biomedich-91	18	5	(	(	PUNCT
biomedich-91	18	6	who	who	PRON
biomedich-91	18	7	)	)	PUNCT
biomedich-91	18	8	analgesic	analgesic	ADJ
biomedich-91	18	9	ladder	ladder	NOUN
biomedich-91	18	10	recommends	recommend	VERB
biomedich-91	18	11	the	the	DET
biomedich-91	18	12	combination	combination	NOUN
biomedich-91	18	13	of	of	ADP
biomedich-91	18	14	acetaminophen	acetaminophen	NOUN
biomedich-91	18	15	or	or	CCONJ
biomedich-91	18	16	nsaids	nsaid	NOUN
biomedich-91	18	17	with	with	ADP
biomedich-91	18	18	opioids	opioid	NOUN
biomedich-91	18	19	as	as	ADP
biomedich-91	18	20	the	the	DET
biomedich-91	18	21	second	second	ADJ
biomedich-91	18	22	step	step	NOUN
biomedich-91	18	23	in	in	ADP
biomedich-91	18	24	the	the	DET
biomedich-91	18	25	treatment	treatment	NOUN
biomedich-91	18	26	of	of	ADP
biomedich-91	18	27	pain	pain	NOUN
biomedich-91	18	28	,	,	PUNCT
biomedich-91	18	29	based	base	VERB
biomedich-91	18	30	on	on	ADP
biomedich-91	18	31	increasing	increase	VERB
biomedich-91	18	32	pain	pain	NOUN
biomedich-91	18	33	severity	severity	NOUN
biomedich-91	18	34	(	(	PUNCT
biomedich-91	18	35	blondel	blondel	NOUN
biomedich-91	18	36	and	and	CCONJ
biomedich-91	18	37	azadfard	azadfard	ADV
biomedich-91	18	38	,	,	PUNCT
biomedich-91	18	39	2013	2013	NUM
biomedich-91	18	40	)	)	PUNCT
biomedich-91	18	41	.	.	PUNCT
biomedich-91	19	1	tramadol	tramadol	NOUN
biomedich-91	19	2	-	-	PUNCT
biomedich-91	19	3	diclofenac	diclofenac	NOUN
biomedich-91	19	4	can	can	AUX
biomedich-91	19	5	be	be	AUX
biomedich-91	19	6	used	use	VERB
biomedich-91	19	7	for	for	ADP
biomedich-91	19	8	the	the	DET
biomedich-91	19	9	treatment	treatment	NOUN
biomedich-91	19	10	or	or	CCONJ
biomedich-91	19	11	management	management	NOUN
biomedich-91	19	12	of	of	ADP
biomedich-91	19	13	chronic	chronic	ADJ
biomedich-91	19	14	pain	pain	NOUN
biomedich-91	19	15	(	(	PUNCT
biomedich-91	19	16	mitra	mitra	PROPN
biomedich-91	19	17	et	et	PROPN
biomedich-91	19	18	al	al	PROPN
biomedich-91	19	19	.	.	PROPN
biomedich-91	19	20	,	,	PUNCT
biomedich-91	19	21	2012	2012	NUM
biomedich-91	19	22	)	)	PUNCT
biomedich-91	19	23	.	.	PUNCT
biomedich-91	20	1	diclofenac	diclofenac	NOUN
biomedich-91	20	2	is	be	AUX
biomedich-91	20	3	a	a	DET
biomedich-91	20	4	phenylacetic	phenylacetic	ADJ
biomedich-91	20	5	acid	acid	NOUN
biomedich-91	20	6	derivative	derivative	NOUN
biomedich-91	20	7	which	which	PRON
biomedich-91	20	8	belongs	belong	VERB
biomedich-91	20	9	to	to	ADP
biomedich-91	20	10	the	the	DET
biomedich-91	20	11	acetic	acetic	ADJ
biomedich-91	20	12	acid	acid	NOUN
biomedich-91	20	13	class	class	NOUN
biomedich-91	20	14	of	of	ADP
biomedich-91	20	15	nsaids	nsaid	NOUN
biomedich-91	20	16	.	.	PUNCT
biomedich-91	21	1	it	it	PRON
biomedich-91	21	2	acts	act	VERB
biomedich-91	21	3	by	by	ADP
biomedich-91	21	4	inhibiting	inhibit	VERB
biomedich-91	21	5	cellular	cellular	ADJ
biomedich-91	21	6	cyclooxygenases	cyclooxygenase	NOUN
biomedich-91	21	7	(	(	PUNCT
biomedich-91	21	8	cox-1	cox-1	X
biomedich-91	21	9	and	and	CCONJ
biomedich-91	21	10	cox-2	cox-2	NUM
biomedich-91	21	11	)	)	PUNCT
biomedich-91	21	12	,	,	PUNCT
biomedich-91	21	13	which	which	PRON
biomedich-91	21	14	results	result	VERB
biomedich-91	21	15	to	to	ADP
biomedich-91	21	16	decreases	decrease	NOUN
biomedich-91	21	17	in	in	ADP
biomedich-91	21	18	the	the	DET
biomedich-91	21	19	production	production	NOUN
biomedich-91	21	20	of	of	ADP
biomedich-91	21	21	proinflammatory	proinflammatory	ADJ
biomedich-91	21	22	prostaglandin	prostaglandin	NOUN
biomedich-91	21	23	,	,	PUNCT
biomedich-91	21	24	prostacyclin	prostacyclin	NOUN
biomedich-91	21	25	and	and	CCONJ
biomedich-91	21	26	thromboxane	thromboxane	NOUN
biomedich-91	21	27	products	product	NOUN
biomedich-91	21	28	which	which	PRON
biomedich-91	21	29	are	be	AUX
biomedich-91	21	30	important	important	ADJ
biomedich-91	21	31	mediators	mediator	NOUN
biomedich-91	21	32	of	of	ADP
biomedich-91	21	33	inflammation	inflammation	NOUN
biomedich-91	21	34	and	and	CCONJ
biomedich-91	21	35	pain	pain	NOUN
biomedich-91	21	36	(	(	PUNCT
biomedich-91	21	37	zimmerman	zimmerman	NOUN
biomedich-91	21	38	,	,	PUNCT
biomedich-91	21	39	1999	1999	NUM
biomedich-91	21	40	;	;	PUNCT
biomedich-91	21	41	lewis	lewis	PROPN
biomedich-91	21	42	and	and	CCONJ
biomedich-91	21	43	stine	stine	PROPN
biomedich-91	21	44	,	,	PUNCT
biomedich-91	21	45	2013	2013	NUM
biomedich-91	21	46	)	)	PUNCT
biomedich-91	21	47	.	.	PUNCT
biomedich-91	22	1	tramadol	tramadol	NOUN
biomedich-91	22	2	is	be	AUX
biomedich-91	22	3	a	a	DET
biomedich-91	22	4	synthetic	synthetic	ADJ
biomedich-91	22	5	codeine	codeine	NOUN
biomedich-91	22	6	analog	analog	NOUN
biomedich-91	22	7	that	that	PRON
biomedich-91	22	8	acts	act	VERB
biomedich-91	22	9	as	as	ADP
biomedich-91	22	10	a	a	DET
biomedich-91	22	11	weak	weak	ADJ
biomedich-91	22	12	opioid	opioid	ADJ
biomedich-91	22	13	agonist	agonist	NOUN
biomedich-91	22	14	in	in	ADP
biomedich-91	22	15	addition	addition	NOUN
biomedich-91	22	16	to	to	ADP
biomedich-91	22	17	mildly	mildly	ADV
biomedich-91	22	18	inhibiting	inhibit	VERB
biomedich-91	22	19	serotonin	serotonin	NOUN
biomedich-91	22	20	and	and	CCONJ
biomedich-91	22	21	norepinephrine	norepinephrine	ADJ
biomedich-91	22	22	reuptake	reuptake	NOUN
biomedich-91	22	23	.	.	PUNCT
biomedich-91	23	1	tramadol	tramadol	NOUN
biomedich-91	23	2	is	be	AUX
biomedich-91	23	3	effective	effective	ADJ
biomedich-91	23	4	against	against	ADP
biomedich-91	23	5	mild	mild	ADJ
biomedich-91	23	6	-	-	PUNCT
biomedich-91	23	7	to	to	ADP
biomedich-91	23	8	-	-	PUNCT
biomedich-91	23	9	moderate	moderate	ADJ
biomedich-91	23	10	pain	pain	NOUN
biomedich-91	23	11	.	.	PUNCT
biomedich-91	24	1	clinically	clinically	ADV
biomedich-91	24	2	,	,	PUNCT
biomedich-91	24	3	tramadol	tramadol	NOUN
biomedich-91	24	4	-	-	PUNCT
biomedich-91	24	5	diclofenac	diclofenac	NOUN
biomedich-91	24	6	use	use	NOUN
biomedich-91	24	7	could	could	AUX
biomedich-91	24	8	advantageously	advantageously	ADV
biomedich-91	24	9	target	target	VERB
biomedich-91	24	10	both	both	CCONJ
biomedich-91	24	11	peripheral	peripheral	ADJ
biomedich-91	24	12	and	and	CCONJ
biomedich-91	24	13	central	central	ADJ
biomedich-91	24	14	pain	pain	NOUN
biomedich-91	24	15	pathways	pathway	NOUN
biomedich-91	24	16	and	and	CCONJ
biomedich-91	24	17	leverage	leverage	NOUN
biomedich-91	24	18	on	on	ADP
biomedich-91	24	19	the	the	DET
biomedich-91	24	20	ability	ability	NOUN
biomedich-91	24	21	of	of	ADP
biomedich-91	24	22	individual	individual	ADJ
biomedich-91	24	23	drug	drug	NOUN
biomedich-91	24	24	to	to	PART
biomedich-91	24	25	reduce	reduce	VERB
biomedich-91	24	26	pain	pain	NOUN
biomedich-91	24	27	and	and	CCONJ
biomedich-91	24	28	fasten	fasten	ADJ
biomedich-91	24	29	recovery	recovery	NOUN
biomedich-91	24	30	(	(	PUNCT
biomedich-91	24	31	raffa	raffa	NOUN
biomedich-91	24	32	,	,	PUNCT
biomedich-91	24	33	2001	2001	NUM
biomedich-91	24	34	)	)	PUNCT
biomedich-91	24	35	.	.	PUNCT
biomedich-91	25	1	however	however	ADV
biomedich-91	25	2	,	,	PUNCT
biomedich-91	25	3	tramadol	tramadol	NOUN
biomedich-91	25	4	-	-	PUNCT
biomedich-91	25	5	diclofenac	diclofenac	NOUN
biomedich-91	25	6	use	use	NOUN
biomedich-91	25	7	may	may	AUX
biomedich-91	25	8	increase	increase	VERB
biomedich-91	25	9	hepatotoxic	hepatotoxic	ADJ
biomedich-91	25	10	risk	risk	NOUN
biomedich-91	25	11	since	since	SCONJ
biomedich-91	25	12	both	both	DET
biomedich-91	25	13	drugs	drug	NOUN
biomedich-91	25	14	have	have	VERB
biomedich-91	25	15	hepatotoxic	hepatotoxic	ADJ
biomedich-91	25	16	potential	potential	NOUN
biomedich-91	25	17	.	.	PUNCT
biomedich-91	26	1	clinically	clinically	ADV
biomedich-91	26	2	,	,	PUNCT
biomedich-91	26	3	apparent	apparent	ADJ
biomedich-91	26	4	liver	liver	NOUN
biomedich-91	26	5	injury	injury	NOUN
biomedich-91	26	6	due	due	ADP
biomedich-91	26	7	to	to	ADP
biomedich-91	26	8	diclofenac	diclofenac	NOUN
biomedich-91	26	9	has	have	AUX
biomedich-91	26	10	been	be	AUX
biomedich-91	26	11	reported	report	VERB
biomedich-91	26	12	and	and	CCONJ
biomedich-91	26	13	it	it	PRON
biomedich-91	26	14	ranks	rank	VERB
biomedich-91	26	15	in	in	ADP
biomedich-91	26	16	the	the	DET
biomedich-91	26	17	top	top	ADJ
biomedich-91	26	18	10	10	NUM
biomedich-91	26	19	causes	cause	NOUN
biomedich-91	26	20	of	of	ADP
biomedich-91	26	21	drug	drug	NOUN
biomedich-91	26	22	-	-	PUNCT
biomedich-91	26	23	induced	induce	VERB
biomedich-91	26	24	liver	liver	NOUN
biomedich-91	26	25	injury	injury	NOUN
biomedich-91	26	26	(	(	PUNCT
biomedich-91	26	27	dunk	dunk	NOUN
biomedich-91	26	28	et	et	PROPN
biomedich-91	26	29	al	al	PROPN
biomedich-91	26	30	.	.	PROPN
biomedich-91	26	31	,	,	PUNCT
biomedich-91	26	32	1982	1982	NUM
biomedich-91	26	33	)	)	PUNCT
biomedich-91	26	34	.	.	PUNCT
biomedich-91	27	1	tramadol	tramadol	NOUN
biomedich-91	27	2	can	can	AUX
biomedich-91	27	3	cause	cause	VERB
biomedich-91	27	4	respiratory	respiratory	ADJ
biomedich-91	27	5	arrest	arrest	NOUN
biomedich-91	27	6	as	as	ADV
biomedich-91	27	7	well	well	ADV
biomedich-91	27	8	as	as	ADP
biomedich-91	27	9	acute	acute	ADJ
biomedich-91	27	10	liver	liver	NOUN
biomedich-91	27	11	failure	failure	NOUN
biomedich-91	27	12	,	,	PUNCT
biomedich-91	27	13	which	which	PRON
biomedich-91	27	14	several	several	ADJ
biomedich-91	27	15	fatal	fatal	ADJ
biomedich-91	27	16	instances	instance	NOUN
biomedich-91	27	17	reported	report	VERB
biomedich-91	27	18	(	(	PUNCT
biomedich-91	27	19	loughrey	loughrey	PROPN
biomedich-91	27	20	et	et	PROPN
biomedich-91	27	21	al	al	PROPN
biomedich-91	27	22	.	.	PROPN
biomedich-91	27	23	,	,	PUNCT
biomedich-91	27	24	2003	2003	NUM
biomedich-91	27	25	)	)	PUNCT
biomedich-91	27	26	.	.	PUNCT
biomedich-91	28	1	the	the	DET
biomedich-91	28	2	use	use	NOUN
biomedich-91	28	3	of	of	ADP
biomedich-91	28	4	tramadol	tramadol	NOUN
biomedich-91	28	5	-	-	PUNCT
biomedich-91	28	6	diclofenac	diclofenac	NOUN
biomedich-91	28	7	calls	call	NOUN
biomedich-91	28	8	for	for	ADP
biomedich-91	28	9	hepatotoxic	hepatotoxic	ADJ
biomedich-91	28	10	assessment	assessment	NOUN
biomedich-91	28	11	which	which	PRON
biomedich-91	28	12	this	this	DET
biomedich-91	28	13	study	study	NOUN
biomedich-91	28	14	evaluated	evaluate	VERB
biomedich-91	28	15	in	in	ADP
biomedich-91	28	16	a	a	DET
biomedich-91	28	17	rat	rat	NOUN
biomedich-91	28	18	model	model	NOUN
biomedich-91	28	19	.	.	PUNCT
biomedich-91	29	1	material	material	NOUN
biomedich-91	29	2	and	and	CCONJ
biomedich-91	29	3	methods	method	NOUN
biomedich-91	29	4	animals	animal	NOUN
biomedich-91	29	5	and	and	CCONJ
biomedich-91	29	6	drugs	drug	NOUN
biomedich-91	29	7	adult	adult	NOUN
biomedich-91	29	8	male	male	NOUN
biomedich-91	29	9	albino	albino	NOUN
biomedich-91	29	10	rats	rat	NOUN
biomedich-91	29	11	of	of	ADP
biomedich-91	29	12	weight	weight	NOUN
biomedich-91	29	13	200	200	NUM
biomedich-91	29	14	-	-	SYM
biomedich-91	29	15	220	220	NUM
biomedich-91	29	16	g	g	NOUN
biomedich-91	29	17	were	be	AUX
biomedich-91	29	18	used	use	VERB
biomedich-91	29	19	.	.	PUNCT
biomedich-91	30	1	the	the	DET
biomedich-91	30	2	rats	rat	NOUN
biomedich-91	30	3	were	be	AUX
biomedich-91	30	4	supplied	supply	VERB
biomedich-91	30	5	by	by	ADP
biomedich-91	30	6	the	the	DET
biomedich-91	30	7	animal	animal	NOUN
biomedich-91	30	8	house	house	NOUN
biomedich-91	30	9	of	of	ADP
biomedich-91	30	10	the	the	DET
biomedich-91	30	11	department	department	PROPN
biomedich-91	30	12	of	of	ADP
biomedich-91	30	13	pharmacology	pharmacology	NOUN
biomedich-91	30	14	and	and	CCONJ
biomedich-91	30	15	toxicology	toxicology	NOUN
biomedich-91	30	16	niger	niger	NOUN
biomedich-91	30	17	,	,	PUNCT
biomedich-91	30	18	delta	delta	NOUN
biomedich-91	30	19	university	university	PROPN
biomedich-91	30	20	,	,	PUNCT
biomedich-91	30	21	nigeria	nigeria	PROPN
biomedich-91	30	22	.	.	PUNCT
biomedich-91	31	1	the	the	DET
biomedich-91	31	2	rats	rat	NOUN
biomedich-91	31	3	were	be	AUX
biomedich-91	31	4	housed	house	VERB
biomedich-91	31	5	in	in	ADP
biomedich-91	31	6	four	four	NUM
biomedich-91	31	7	cages	cage	NOUN
biomedich-91	31	8	(	(	PUNCT
biomedich-91	31	9	6	6	NUM
biomedich-91	31	10	per	per	ADP
biomedich-91	31	11	cage	cage	NOUN
biomedich-91	31	12	)	)	PUNCT
biomedich-91	31	13	and	and	CCONJ
biomedich-91	31	14	allowed	allow	VERB
biomedich-91	31	15	to	to	PART
biomedich-91	31	16	acclimatize	acclimatize	VERB
biomedich-91	31	17	for	for	ADP
biomedich-91	31	18	2	2	NUM
biomedich-91	31	19	weeks	week	NOUN
biomedich-91	31	20	in	in	ADP
biomedich-91	31	21	a	a	DET
biomedich-91	31	22	well	well	ADV
biomedich-91	31	23	-	-	PUNCT
biomedich-91	31	24	ventilated	ventilate	VERB
biomedich-91	31	25	room	room	NOUN
biomedich-91	31	26	,	,	PUNCT
biomedich-91	31	27	maintained	maintain	VERB
biomedich-91	31	28	at	at	ADP
biomedich-91	31	29	a	a	DET
biomedich-91	31	30	room	room	NOUN
biomedich-91	31	31	temperature	temperature	NOUN
biomedich-91	31	32	of	of	ADP
biomedich-91	31	33	28	28	NUM
biomedich-91	31	34	±	±	NUM
biomedich-91	31	35	2	2	NUM
biomedich-91	31	36	°	°	NOUN
biomedich-91	31	37	c	c	NOUN
biomedich-91	31	38	,	,	PUNCT
biomedich-91	31	39	under	under	ADP
biomedich-91	31	40	natural	natural	ADJ
biomedich-91	31	41	lighting	lighting	NOUN
biomedich-91	31	42	condition	condition	NOUN
biomedich-91	31	43	.	.	PUNCT
biomedich-91	32	1	the	the	DET
biomedich-91	32	2	rats	rat	NOUN
biomedich-91	32	3	were	be	AUX
biomedich-91	32	4	fed	feed	VERB
biomedich-91	32	5	with	with	ADP
biomedich-91	32	6	standard	standard	ADJ
biomedich-91	32	7	rodents	rodent	NOUN
biomedich-91	32	8	chow	chow	VERB
biomedich-91	32	9	https://doi.org/10.14421/biomedich.2019.82.41-45	https://doi.org/10.14421/biomedich.2019.82.41-45	NOUN
biomedich-91	32	10	42	42	NUM
biomedich-91	32	11	biology	biology	NOUN
biomedich-91	32	12	,	,	PUNCT
biomedich-91	32	13	medicine	medicine	NOUN
biomedich-91	32	14	,	,	PUNCT
biomedich-91	32	15	&	&	CCONJ
biomedich-91	32	16	natural	natural	ADJ
biomedich-91	32	17	product	product	NOUN
biomedich-91	32	18	chemistry	chemistry	NOUN
biomedich-91	32	19	8	8	NUM
biomedich-91	32	20	(	(	PUNCT
biomedich-91	32	21	2	2	NUM
biomedich-91	32	22	)	)	PUNCT
biomedich-91	32	23	,	,	PUNCT
biomedich-91	32	24	2019	2019	NUM
biomedich-91	32	25	:	:	PUNCT
biomedich-91	32	26	41	41	NUM
biomedich-91	32	27	-	-	SYM
biomedich-91	32	28	45	45	NUM
biomedich-91	32	29	and	and	CCONJ
biomedich-91	32	30	given	give	VERB
biomedich-91	32	31	water	water	NOUN
biomedich-91	32	32	ad	ad	NOUN
biomedich-91	32	33	libitum	libitum	X
biomedich-91	32	34	.	.	PUNCT
biomedich-91	33	1	tramadol	tramadol	NOUN
biomedich-91	33	2	hydrochloride	hydrochloride	NOUN
biomedich-91	33	3	(	(	PUNCT
biomedich-91	33	4	zim	zim	PROPN
biomedich-91	33	5	laboratories	laboratories	PROPN
biomedich-91	33	6	ltd	ltd	PROPN
biomedich-91	33	7	india	india	PROPN
biomedich-91	33	8	)	)	PUNCT
biomedich-91	33	9	and	and	CCONJ
biomedich-91	33	10	diclofenac	diclofenac	NOUN
biomedich-91	33	11	potassium	potassium	NOUN
biomedich-91	33	12	(	(	PUNCT
biomedich-91	33	13	adpharm	adpharm	PROPN
biomedich-91	33	14	nigeria	nigeria	PROPN
biomedich-91	33	15	ltd	ltd	PROPN
biomedich-91	33	16	)	)	PUNCT
biomedich-91	33	17	were	be	AUX
biomedich-91	33	18	used	use	VERB
biomedich-91	33	19	for	for	ADP
biomedich-91	33	20	this	this	DET
biomedich-91	33	21	study	study	NOUN
biomedich-91	33	22	.	.	PUNCT
biomedich-91	34	1	all	all	DET
biomedich-91	34	2	other	other	ADJ
biomedich-91	34	3	chemical	chemical	ADJ
biomedich-91	34	4	substances	substance	NOUN
biomedich-91	34	5	used	use	VERB
biomedich-91	34	6	for	for	ADP
biomedich-91	34	7	this	this	DET
biomedich-91	34	8	study	study	NOUN
biomedich-91	34	9	are	be	AUX
biomedich-91	34	10	of	of	ADP
biomedich-91	34	11	analytical	analytical	ADJ
biomedich-91	34	12	grade	grade	NOUN
biomedich-91	34	13	.	.	PUNCT
biomedich-91	35	1	higher	high	ADJ
biomedich-91	35	2	doses	dose	NOUN
biomedich-91	35	3	of	of	ADP
biomedich-91	35	4	tramadol	tramadol	NOUN
biomedich-91	35	5	(	(	PUNCT
biomedich-91	35	6	12mg	12mg	ADJ
biomedich-91	35	7	/	/	SYM
biomedich-91	35	8	kg	kg	NOUN
biomedich-91	35	9	/	/	SYM
biomedich-91	35	10	day	day	NOUN
biomedich-91	35	11	)	)	PUNCT
biomedich-91	35	12	and	and	CCONJ
biomedich-91	35	13	diclofenac	diclofenac	NOUN
biomedich-91	35	14	(	(	PUNCT
biomedich-91	35	15	6mg	6mg	ADJ
biomedich-91	35	16	/	/	SYM
biomedich-91	35	17	kg	kg	ADJ
biomedich-91	35	18	/	/	SYM
biomedich-91	35	19	day	day	NOUN
biomedich-91	35	20	)	)	PUNCT
biomedich-91	35	21	dissolved	dissolve	VERB
biomedich-91	35	22	in	in	ADP
biomedich-91	35	23	normal	normal	ADJ
biomedich-91	35	24	saline	saline	NOUN
biomedich-91	35	25	were	be	AUX
biomedich-91	35	26	used	use	VERB
biomedich-91	35	27	for	for	ADP
biomedich-91	35	28	this	this	DET
biomedich-91	35	29	study	study	NOUN
biomedich-91	35	30	.	.	PUNCT
biomedich-91	36	1	grouping	group	VERB
biomedich-91	36	2	of	of	ADP
biomedich-91	36	3	animals	animal	NOUN
biomedich-91	36	4	and	and	CCONJ
biomedich-91	36	5	drug	drug	NOUN
biomedich-91	36	6	treatment	treatment	NOUN
biomedich-91	36	7	twenty	twenty	NUM
biomedich-91	36	8	-	-	PUNCT
biomedich-91	36	9	four	four	NUM
biomedich-91	36	10	adult	adult	NOUN
biomedich-91	36	11	male	male	NOUN
biomedich-91	36	12	albino	albino	NOUN
biomedich-91	36	13	rats	rat	NOUN
biomedich-91	36	14	were	be	AUX
biomedich-91	36	15	divided	divide	VERB
biomedich-91	36	16	into	into	ADP
biomedich-91	36	17	four	four	NUM
biomedich-91	36	18	(	(	PUNCT
biomedich-91	36	19	4	4	NUM
biomedich-91	36	20	)	)	PUNCT
biomedich-91	36	21	groups	group	NOUN
biomedich-91	36	22	a	a	PROPN
biomedich-91	36	23	-	-	PUNCT
biomedich-91	36	24	d	d	NOUN
biomedich-91	36	25	of	of	ADP
biomedich-91	36	26	6	6	NUM
biomedich-91	36	27	rats	rat	NOUN
biomedich-91	36	28	each	each	PRON
biomedich-91	36	29	.	.	PUNCT
biomedich-91	37	1			PROPN
biomedich-91	38	1	group	group	PROPN
biomedich-91	38	2	a	a	DET
biomedich-91	38	3	(	(	PUNCT
biomedich-91	38	4	control	control	NOUN
biomedich-91	38	5	)	)	PUNCT
biomedich-91	38	6	was	be	AUX
biomedich-91	38	7	orally	orally	ADV
biomedich-91	38	8	administered	administer	VERB
biomedich-91	38	9	with	with	ADP
biomedich-91	38	10	normal	normal	ADJ
biomedich-91	38	11	saline	saline	NOUN
biomedich-91	38	12	(	(	PUNCT
biomedich-91	38	13	0.2ml	0.2ml	NUM
biomedich-91	38	14	)	)	PUNCT
biomedich-91	38	15	for	for	ADP
biomedich-91	38	16	14	14	NUM
biomedich-91	38	17	days	day	NOUN
biomedich-91	38	18	.	.	PUNCT
biomedich-91	39	1			PROPN
biomedich-91	40	1	group	group	PROPN
biomedich-91	40	2	b	b	PROPN
biomedich-91	40	3	was	be	AUX
biomedich-91	40	4	orally	orally	ADV
biomedich-91	40	5	administered	administer	VERB
biomedich-91	40	6	with	with	ADP
biomedich-91	40	7	tramadol	tramadol	NOUN
biomedich-91	40	8	(	(	PUNCT
biomedich-91	40	9	12	12	NUM
biomedich-91	40	10	mg	mg	PROPN
biomedich-91	40	11	/	/	SYM
biomedich-91	40	12	kg	kg	PROPN
biomedich-91	40	13	/	/	SYM
biomedich-91	40	14	day	day	NOUN
biomedich-91	40	15	)	)	PUNCT
biomedich-91	40	16	for	for	ADP
biomedich-91	40	17	14	14	NUM
biomedich-91	40	18	days	day	NOUN
biomedich-91	40	19	.	.	PUNCT
biomedich-91	41	1			PROPN
biomedich-91	42	1	group	group	NOUN
biomedich-91	42	2	c	c	PROPN
biomedich-91	42	3	was	be	AUX
biomedich-91	42	4	orally	orally	ADV
biomedich-91	42	5	administered	administer	VERB
biomedich-91	42	6	with	with	ADP
biomedich-91	42	7	diclofenac	diclofenac	NOUN
biomedich-91	42	8	(	(	PUNCT
biomedich-91	42	9	6mg	6mg	ADJ
biomedich-91	42	10	/	/	SYM
biomedich-91	42	11	kg	kg	PROPN
biomedich-91	42	12	/	/	SYM
biomedich-91	42	13	day	day	NOUN
biomedich-91	42	14	)	)	PUNCT
biomedich-91	42	15	for	for	ADP
biomedich-91	42	16	14	14	NUM
biomedich-91	42	17	days	day	NOUN
biomedich-91	42	18	.	.	PUNCT
biomedich-91	43	1			PROPN
biomedich-91	44	1	group	group	NOUN
biomedich-91	44	2	d	d	PROPN
biomedich-91	44	3	was	be	AUX
biomedich-91	44	4	orally	orally	ADV
biomedich-91	44	5	administered	administer	VERB
biomedich-91	44	6	with	with	ADP
biomedich-91	44	7	tramadol	tramadol	NOUN
biomedich-91	44	8	(	(	PUNCT
biomedich-91	44	9	12mg	12mg	ADJ
biomedich-91	44	10	/	/	SYM
biomedich-91	44	11	kg	kg	NOUN
biomedich-91	44	12	/	/	SYM
biomedich-91	44	13	day	day	NOUN
biomedich-91	44	14	)	)	PUNCT
biomedich-91	44	15	and	and	CCONJ
biomedich-91	44	16	diclofenac	diclofenac	NOUN
biomedich-91	44	17	(	(	PUNCT
biomedich-91	44	18	6mg	6mg	ADJ
biomedich-91	44	19	/	/	SYM
biomedich-91	44	20	kg	kg	PROPN
biomedich-91	44	21	/	/	SYM
biomedich-91	44	22	day	day	NOUN
biomedich-91	44	23	)	)	PUNCT
biomedich-91	44	24	for	for	ADP
biomedich-91	44	25	14	14	NUM
biomedich-91	44	26	days	day	NOUN
biomedich-91	44	27	.	.	PUNCT
biomedich-91	45	1	collection	collection	NOUN
biomedich-91	45	2	of	of	ADP
biomedich-91	45	3	sample	sample	NOUN
biomedich-91	45	4	the	the	DET
biomedich-91	45	5	rats	rat	NOUN
biomedich-91	45	6	were	be	AUX
biomedich-91	45	7	sacrificed	sacrifice	VERB
biomedich-91	45	8	with	with	ADP
biomedich-91	45	9	inhalational	inhalational	ADJ
biomedich-91	45	10	diethyl	diethyl	NOUN
biomedich-91	45	11	ether	ether	NOUN
biomedich-91	45	12	after	after	ADP
biomedich-91	45	13	drug	drug	NOUN
biomedich-91	45	14	administration	administration	NOUN
biomedich-91	45	15	and	and	CCONJ
biomedich-91	45	16	blood	blood	NOUN
biomedich-91	45	17	samples	sample	NOUN
biomedich-91	45	18	were	be	AUX
biomedich-91	45	19	collected	collect	VERB
biomedich-91	45	20	from	from	ADP
biomedich-91	45	21	the	the	DET
biomedich-91	45	22	heart	heart	NOUN
biomedich-91	45	23	.	.	PUNCT
biomedich-91	46	1	at	at	ADP
biomedich-91	46	2	1500	1500	NUM
biomedich-91	46	3	g	g	NOUN
biomedich-91	46	4	for	for	ADP
biomedich-91	46	5	15	15	NUM
biomedich-91	46	6	minutes	minute	NOUN
biomedich-91	46	7	,	,	PUNCT
biomedich-91	46	8	the	the	DET
biomedich-91	46	9	blood	blood	NOUN
biomedich-91	46	10	samples	sample	NOUN
biomedich-91	46	11	were	be	AUX
biomedich-91	46	12	centrifuged	centrifuge	VERB
biomedich-91	46	13	,	,	PUNCT
biomedich-91	46	14	serum	serum	NOUN
biomedich-91	46	15	samples	sample	NOUN
biomedich-91	46	16	extracted	extract	VERB
biomedich-91	46	17	and	and	CCONJ
biomedich-91	46	18	evaluated	evaluate	VERB
biomedich-91	46	19	for	for	ADP
biomedich-91	46	20	liver	liver	NOUN
biomedich-91	46	21	function	function	NOUN
biomedich-91	46	22	parameters	parameter	NOUN
biomedich-91	46	23	.	.	PUNCT
biomedich-91	47	1	liver	liver	NOUN
biomedich-91	47	2	samples	sample	NOUN
biomedich-91	47	3	were	be	AUX
biomedich-91	47	4	harvested	harvest	VERB
biomedich-91	47	5	and	and	CCONJ
biomedich-91	47	6	washed	wash	VERB
biomedich-91	47	7	in	in	ADP
biomedich-91	47	8	a	a	DET
biomedich-91	47	9	cold	cold	ADJ
biomedich-91	47	10	1.15	1.15	NUM
biomedich-91	47	11	%	%	NOUN
biomedich-91	47	12	kcl	kcl	NOUN
biomedich-91	47	13	solution	solution	NOUN
biomedich-91	47	14	and	and	CCONJ
biomedich-91	47	15	homogenized	homogenize	VERB
biomedich-91	47	16	in	in	ADP
biomedich-91	47	17	0.1	0.1	NUM
biomedich-91	47	18	m	m	PROPN
biomedich-91	47	19	trishcl	trishcl	ADJ
biomedich-91	47	20	buffer	buffer	NOUN
biomedich-91	47	21	,	,	PUNCT
biomedich-91	47	22	ph	ph	NOUN
biomedich-91	47	23	7.4	7.4	NUM
biomedich-91	47	24	.	.	PUNCT
biomedich-91	48	1	the	the	DET
biomedich-91	48	2	homogenates	homogenate	NOUN
biomedich-91	48	3	were	be	AUX
biomedich-91	48	4	centrifuged	centrifuge	VERB
biomedich-91	48	5	at	at	ADP
biomedich-91	48	6	1500	1500	NUM
biomedich-91	48	7	g	g	NOUN
biomedich-91	48	8	for	for	ADP
biomedich-91	48	9	15	15	NUM
biomedich-91	48	10	minutes	minute	NOUN
biomedich-91	48	11	and	and	CCONJ
biomedich-91	48	12	the	the	DET
biomedich-91	48	13	supernatants	supernatant	NOUN
biomedich-91	48	14	were	be	AUX
biomedich-91	48	15	decanted	decant	VERB
biomedich-91	48	16	and	and	CCONJ
biomedich-91	48	17	evaluated	evaluate	VERB
biomedich-91	48	18	for	for	ADP
biomedich-91	48	19	biochemical	biochemical	ADJ
biomedich-91	48	20	parameters	parameter	NOUN
biomedich-91	48	21	.	.	PUNCT
biomedich-91	49	1	evaluation	evaluation	NOUN
biomedich-91	49	2	of	of	ADP
biomedich-91	49	3	biochemical	biochemical	ADJ
biomedich-91	49	4	and	and	CCONJ
biomedich-91	49	5	oxidative	oxidative	ADJ
biomedich-91	49	6	stress	stress	NOUN
biomedich-91	49	7	indices	index	NOUN
biomedich-91	49	8	aspartate	aspartate	NOUN
biomedich-91	49	9	aminotransferase	aminotransferase	NOUN
biomedich-91	49	10	(	(	PUNCT
biomedich-91	49	11	ast	ast	PROPN
biomedich-91	49	12	)	)	PUNCT
biomedich-91	49	13	,	,	PUNCT
biomedich-91	49	14	alanine	alanine	NOUN
biomedich-91	49	15	aminotransferase	aminotransferase	PROPN
biomedich-91	49	16	(	(	PUNCT
biomedich-91	49	17	alt	alt	PROPN
biomedich-91	49	18	)	)	PUNCT
biomedich-91	49	19	,	,	PUNCT
biomedich-91	49	20	alkaline	alkaline	NOUN
biomedich-91	49	21	phosphatase	phosphatase	NOUN
biomedich-91	49	22	(	(	PUNCT
biomedich-91	49	23	alp	alp	PROPN
biomedich-91	49	24	)	)	PUNCT
biomedich-91	49	25	,	,	PUNCT
biomedich-91	49	26	total	total	ADJ
biomedich-91	49	27	bilirubin	bilirubin	NOUN
biomedich-91	49	28	(	(	PUNCT
biomedich-91	49	29	tb	tb	NOUN
biomedich-91	49	30	)	)	PUNCT
biomedich-91	49	31	,	,	PUNCT
biomedich-91	49	32	conjugated	conjugate	VERB
biomedich-91	49	33	bilirubin	bilirubin	NOUN
biomedich-91	49	34	(	(	PUNCT
biomedich-91	49	35	cb	cb	PROPN
biomedich-91	49	36	)	)	PUNCT
biomedich-91	49	37	,	,	PUNCT
biomedich-91	49	38	gammaglutamyl	gammaglutamyl	NOUN
biomedich-91	49	39	transferase	transferase	NOUN
biomedich-91	49	40	(	(	PUNCT
biomedich-91	49	41	ggt	ggt	NOUN
biomedich-91	49	42	)	)	PUNCT
biomedich-91	49	43	,	,	PUNCT
biomedich-91	49	44	lactate	lactate	NOUN
biomedich-91	49	45	dehydrogenase	dehydrogenase	NOUN
biomedich-91	49	46	(	(	PUNCT
biomedich-91	49	47	ldh	ldh	NOUN
biomedich-91	49	48	)	)	PUNCT
biomedich-91	49	49	,	,	PUNCT
biomedich-91	49	50	total	total	ADJ
biomedich-91	49	51	cholesterol	cholesterol	NOUN
biomedich-91	49	52	(	(	PUNCT
biomedich-91	49	53	tc	tc	NOUN
biomedich-91	49	54	)	)	PUNCT
biomedich-91	49	55	,	,	PUNCT
biomedich-91	49	56	triglyceride	triglyceride	INTJ
biomedich-91	49	57	(	(	PUNCT
biomedich-91	49	58	tg	tg	INTJ
biomedich-91	49	59	)	)	PUNCT
biomedich-91	49	60	and	and	CCONJ
biomedich-91	49	61	high	high	ADJ
biomedich-91	49	62	density	density	NOUN
biomedich-91	49	63	lipoprotein	lipoprotein	ADJ
biomedich-91	49	64	cholesterol	cholesterol	NOUN
biomedich-91	49	65	(	(	PUNCT
biomedich-91	49	66	hdl	hdl	NOUN
biomedich-91	49	67	-	-	PUNCT
biomedich-91	49	68	c	c	NOUN
biomedich-91	49	69	)	)	PUNCT
biomedich-91	49	70	were	be	AUX
biomedich-91	49	71	evaluated	evaluate	VERB
biomedich-91	49	72	using	use	VERB
biomedich-91	49	73	standard	standard	ADJ
biomedich-91	49	74	laboratory	laboratory	NOUN
biomedich-91	49	75	test	test	NOUN
biomedich-91	49	76	kits	kit	NOUN
biomedich-91	49	77	.	.	PUNCT
biomedich-91	50	1	blood	blood	NOUN
biomedich-91	50	2	glucose	glucose	NOUN
biomedich-91	50	3	(	(	PUNCT
biomedich-91	50	4	g	g	NOUN
biomedich-91	50	5	)	)	PUNCT
biomedich-91	50	6	was	be	AUX
biomedich-91	50	7	evaluated	evaluate	VERB
biomedich-91	50	8	using	use	VERB
biomedich-91	50	9	glucometer	glucometer	NOUN
biomedich-91	50	10	while	while	SCONJ
biomedich-91	50	11	low	low	ADJ
biomedich-91	50	12	density	density	NOUN
biomedich-91	50	13	lipoprotein	lipoprotein	ADJ
biomedich-91	50	14	cholesterol	cholesterol	NOUN
biomedich-91	50	15	(	(	PUNCT
biomedich-91	50	16	ldl	ldl	NOUN
biomedich-91	50	17	-	-	PUNCT
biomedich-91	50	18	c	c	NOUN
biomedich-91	50	19	)	)	PUNCT
biomedich-91	50	20	was	be	AUX
biomedich-91	50	21	determined	determine	VERB
biomedich-91	50	22	using	use	VERB
biomedich-91	50	23	friedewald	friedewald	ADJ
biomedich-91	50	24	equation	equation	NOUN
biomedich-91	50	25	.	.	PUNCT
biomedich-91	51	1	liver	liver	NOUN
biomedich-91	51	2	protein	protein	NOUN
biomedich-91	51	3	was	be	AUX
biomedich-91	51	4	evaluated	evaluate	VERB
biomedich-91	51	5	according	accord	VERB
biomedich-91	51	6	to	to	ADP
biomedich-91	51	7	gornall	gornall	PROPN
biomedich-91	51	8	et	et	PROPN
biomedich-91	51	9	al	al	PROPN
biomedich-91	51	10	.	.	PROPN
biomedich-91	52	1	(	(	PUNCT
biomedich-91	52	2	1949	1949	NUM
biomedich-91	52	3	)	)	PUNCT
biomedich-91	52	4	.	.	PUNCT
biomedich-91	53	1	the	the	DET
biomedich-91	53	2	method	method	NOUN
biomedich-91	53	3	described	describe	VERB
biomedich-91	53	4	by	by	ADP
biomedich-91	53	5	sun	sun	NOUN
biomedich-91	53	6	and	and	CCONJ
biomedich-91	53	7	zigma	zigma	PROPN
biomedich-91	53	8	,	,	PUNCT
biomedich-91	53	9	(	(	PUNCT
biomedich-91	53	10	1978	1978	NUM
biomedich-91	53	11	)	)	PUNCT
biomedich-91	53	12	was	be	AUX
biomedich-91	53	13	used	use	VERB
biomedich-91	53	14	for	for	ADP
biomedich-91	53	15	the	the	DET
biomedich-91	53	16	evaluation	evaluation	NOUN
biomedich-91	53	17	of	of	ADP
biomedich-91	53	18	superoxide	superoxide	NOUN
biomedich-91	53	19	dismutase	dismutase	NOUN
biomedich-91	53	20	(	(	PUNCT
biomedich-91	53	21	sod	sod	NOUN
biomedich-91	53	22	)	)	PUNCT
biomedich-91	53	23	whereas	whereas	SCONJ
biomedich-91	53	24	catalase	catalase	NOUN
biomedich-91	53	25	(	(	PUNCT
biomedich-91	53	26	cat	cat	NOUN
biomedich-91	53	27	)	)	PUNCT
biomedich-91	53	28	was	be	AUX
biomedich-91	53	29	determined	determine	VERB
biomedich-91	53	30	according	accord	VERB
biomedich-91	53	31	to	to	ADP
biomedich-91	53	32	aebi	aebi	ADJ
biomedich-91	53	33	,	,	PUNCT
biomedich-91	53	34	(	(	PUNCT
biomedich-91	53	35	1984	1984	NUM
biomedich-91	53	36	)	)	PUNCT
biomedich-91	53	37	.	.	PUNCT
biomedich-91	54	1	glutathione	glutathione	NOUN
biomedich-91	54	2	(	(	PUNCT
biomedich-91	54	3	gsh	gsh	PROPN
biomedich-91	54	4	)	)	PUNCT
biomedich-91	54	5	was	be	AUX
biomedich-91	54	6	estimated	estimate	VERB
biomedich-91	54	7	as	as	SCONJ
biomedich-91	54	8	described	describe	VERB
biomedich-91	54	9	by	by	ADP
biomedich-91	54	10	sedlak	sedlak	NOUN
biomedich-91	54	11	and	and	CCONJ
biomedich-91	54	12	lindsay	lindsay	PROPN
biomedich-91	54	13	,	,	PUNCT
biomedich-91	54	14	(	(	PUNCT
biomedich-91	54	15	1968	1968	NUM
biomedich-91	54	16	)	)	PUNCT
biomedich-91	54	17	whereas	whereas	SCONJ
biomedich-91	54	18	glutathione	glutathione	NOUN
biomedich-91	54	19	peroxidase	peroxidase	NOUN
biomedich-91	54	20	(	(	PUNCT
biomedich-91	54	21	gpx	gpx	PROPN
biomedich-91	54	22	)	)	PUNCT
biomedich-91	54	23	was	be	AUX
biomedich-91	54	24	evaluated	evaluate	VERB
biomedich-91	54	25	according	accord	VERB
biomedich-91	54	26	to	to	ADP
biomedich-91	54	27	the	the	DET
biomedich-91	54	28	method	method	NOUN
biomedich-91	54	29	of	of	ADP
biomedich-91	54	30	rotruck	rotruck	NOUN
biomedich-91	54	31	,	,	PUNCT
biomedich-91	54	32	et	et	PROPN
biomedich-91	54	33	al	al	PROPN
biomedich-91	54	34	,	,	PUNCT
biomedich-91	54	35	(	(	PUNCT
biomedich-91	54	36	1973	1973	NUM
biomedich-91	54	37	)	)	PUNCT
biomedich-91	54	38	.	.	PUNCT
biomedich-91	55	1	malondialdehyde	malondialdehyde	NOUN
biomedich-91	55	2	(	(	PUNCT
biomedich-91	55	3	mda	mda	PROPN
biomedich-91	55	4	)	)	PUNCT
biomedich-91	55	5	was	be	AUX
biomedich-91	55	6	determined	determine	VERB
biomedich-91	55	7	as	as	SCONJ
biomedich-91	55	8	reported	report	VERB
biomedich-91	55	9	by	by	ADP
biomedich-91	55	10	buege	buege	PROPN
biomedich-91	55	11	and	and	CCONJ
biomedich-91	55	12	aust	aust	PROPN
biomedich-91	55	13	,	,	PUNCT
biomedich-91	55	14	(	(	PUNCT
biomedich-91	55	15	1978	1978	NUM
biomedich-91	55	16	)	)	PUNCT
biomedich-91	55	17	.	.	PUNCT
biomedich-91	56	1	histological	histological	ADJ
biomedich-91	56	2	examination	examination	NOUN
biomedich-91	56	3	of	of	ADP
biomedich-91	56	4	the	the	DET
biomedich-91	56	5	liver	liver	NOUN
biomedich-91	56	6	liver	liver	NOUN
biomedich-91	56	7	samples	sample	NOUN
biomedich-91	56	8	were	be	AUX
biomedich-91	56	9	fixed	fix	VERB
biomedich-91	56	10	in	in	ADP
biomedich-91	56	11	10	10	NUM
biomedich-91	56	12	%	%	NOUN
biomedich-91	56	13	neutral	neutral	ADJ
biomedich-91	56	14	buffered	buffer	VERB
biomedich-91	56	15	formalin	formalin	NOUN
biomedich-91	56	16	,	,	PUNCT
biomedich-91	56	17	processed	process	VERB
biomedich-91	56	18	and	and	CCONJ
biomedich-91	56	19	embedded	embed	VERB
biomedich-91	56	20	in	in	ADP
biomedich-91	56	21	paraffin	paraffin	NOUN
biomedich-91	56	22	wax	wax	NOUN
biomedich-91	56	23	.	.	PUNCT
biomedich-91	57	1	sections	section	NOUN
biomedich-91	57	2	of	of	ADP
biomedich-91	57	3	5	5	NUM
biomedich-91	57	4	μm	μm	NOUN
biomedich-91	57	5	thickness	thickness	NOUN
biomedich-91	57	6	were	be	AUX
biomedich-91	57	7	cut	cut	VERB
biomedich-91	57	8	,	,	PUNCT
biomedich-91	57	9	stained	stain	VERB
biomedich-91	57	10	with	with	ADP
biomedich-91	57	11	haematoxylin	haematoxylin	NOUN
biomedich-91	57	12	and	and	CCONJ
biomedich-91	57	13	eosin	eosin	NOUN
biomedich-91	57	14	and	and	CCONJ
biomedich-91	57	15	examined	examine	VERB
biomedich-91	57	16	under	under	ADP
biomedich-91	57	17	a	a	DET
biomedich-91	57	18	light	light	ADJ
biomedich-91	57	19	microscope	microscope	NOUN
biomedich-91	57	20	and	and	CCONJ
biomedich-91	57	21	relevant	relevant	ADJ
biomedich-91	57	22	sections	section	NOUN
biomedich-91	57	23	photographed	photograph	VERB
biomedich-91	57	24	.	.	PUNCT
biomedich-91	58	1	statistical	statistical	ADJ
biomedich-91	58	2	analysis	analysis	NOUN
biomedich-91	58	3	data	datum	NOUN
biomedich-91	58	4	are	be	AUX
biomedich-91	58	5	expressed	express	VERB
biomedich-91	58	6	as	as	ADP
biomedich-91	58	7	mean	mean	PROPN
biomedich-91	58	8	±	±	NUM
biomedich-91	58	9	sem	sem	PROPN
biomedich-91	58	10	.	.	PUNCT
biomedich-91	59	1	data	datum	NOUN
biomedich-91	59	2	was	be	AUX
biomedich-91	59	3	subjected	subject	VERB
biomedich-91	59	4	to	to	ADP
biomedich-91	59	5	student	student	NOUN
biomedich-91	59	6	t	t	PROPN
biomedich-91	59	7	test	test	NOUN
biomedich-91	59	8	.	.	PUNCT
biomedich-91	60	1	results	result	NOUN
biomedich-91	60	2	were	be	AUX
biomedich-91	60	3	considered	consider	VERB
biomedich-91	60	4	to	to	PART
biomedich-91	60	5	be	be	AUX
biomedich-91	60	6	significant	significant	ADJ
biomedich-91	60	7	at	at	ADP
biomedich-91	60	8	p<0.05	p<0.05	NOUN
biomedich-91	60	9	;	;	PUNCT
biomedich-91	60	10	0.01	0.01	NUM
biomedich-91	60	11	;	;	PUNCT
biomedich-91	60	12	0.001	0.001	NUM
biomedich-91	60	13	.	.	PUNCT
biomedich-91	60	14	table	table	NOUN
biomedich-91	60	15	1	1	NUM
biomedich-91	60	16	.	.	PUNCT
biomedich-91	60	17	effects	effect	NOUN
biomedich-91	60	18	of	of	ADP
biomedich-91	60	19	tramadol	tramadol	NOUN
biomedich-91	60	20	-	-	PUNCT
biomedich-91	60	21	diclofenac	diclofenac	NOUN
biomedich-91	60	22	on	on	ADP
biomedich-91	60	23	body	body	NOUN
biomedich-91	60	24	and	and	CCONJ
biomedich-91	60	25	liver	liver	NOUN
biomedich-91	60	26	weights	weight	NOUN
biomedich-91	60	27	of	of	ADP
biomedich-91	60	28	albino	albino	NOUN
biomedich-91	60	29	rats	rat	NOUN
biomedich-91	60	30	.	.	PUNCT
biomedich-91	61	1	groups	group	NOUN
biomedich-91	61	2	body	body	VERB
biomedich-91	61	3	weight	weight	NOUN
biomedich-91	61	4	(	(	PUNCT
biomedich-91	61	5	g	g	NOUN
biomedich-91	61	6	)	)	PUNCT
biomedich-91	61	7	absolute	absolute	ADJ
biomedich-91	61	8	liver	liver	NOUN
biomedich-91	61	9	weight(g	weight(g	NOUN
biomedich-91	61	10	)	)	PUNCT
biomedich-91	61	11	relative	relative	ADJ
biomedich-91	61	12	liver	liver	NOUN
biomedich-91	61	13	weight	weight	NOUN
biomedich-91	61	14	(	(	PUNCT
biomedich-91	61	15	%	%	INTJ
biomedich-91	61	16	)	)	PUNCT
biomedich-91	61	17	a	a	DET
biomedich-91	61	18	b	b	NOUN
biomedich-91	61	19	c	c	NOUN
biomedich-91	62	1	d	d	X
biomedich-91	62	2	290±11.3	290±11.3	NUM
biomedich-91	62	3	295±14.2	295±14.2	NUM
biomedich-91	62	4	275±10.6	275±10.6	NUM
biomedich-91	62	5	295±11.5	295±11.5	NUM
biomedich-91	62	6	6.03±0.13	6.03±0.13	NUM
biomedich-91	63	1	6.22±0.25	6.22±0.25	NOUN
biomedich-91	64	1	5.99±0.31	5.99±0.31	NUM
biomedich-91	64	2	6.21±0.19	6.21±0.19	NUM
biomedich-91	64	3	2.07±0.01	2.07±0.01	ADJ
biomedich-91	64	4	2.10±0.73	2.10±0.73	NUM
biomedich-91	64	5	2.17±0.59	2.17±0.59	NUM
biomedich-91	64	6	2.10±0.77	2.10±0.77	NUM
biomedich-91	64	7	n=6	n=6	NOUN
biomedich-91	64	8	.	.	PUNCT
biomedich-91	65	1	data	datum	NOUN
biomedich-91	65	2	are	be	AUX
biomedich-91	65	3	expressed	express	VERB
biomedich-91	65	4	as	as	ADP
biomedich-91	65	5	mean	mean	PROPN
biomedich-91	65	6	±	±	NUM
biomedich-91	65	7	sem	sem	PROPN
biomedich-91	65	8	.	.	PUNCT
biomedich-91	65	9	table	table	NOUN
biomedich-91	65	10	2	2	NUM
biomedich-91	65	11	.	.	PUNCT
biomedich-91	65	12	effects	effect	NOUN
biomedich-91	65	13	of	of	ADP
biomedich-91	65	14	tramadol	tramadol	NOUN
biomedich-91	65	15	-	-	PUNCT
biomedich-91	65	16	diclofenac	diclofenac	NOUN
biomedich-91	65	17	on	on	ADP
biomedich-91	65	18	blood	blood	NOUN
biomedich-91	65	19	glucose	glucose	NOUN
biomedich-91	65	20	and	and	CCONJ
biomedich-91	65	21	serum	serum	NOUN
biomedich-91	65	22	lipids	lipid	NOUN
biomedich-91	65	23	of	of	ADP
biomedich-91	65	24	albino	albino	NOUN
biomedich-91	65	25	rats	rat	NOUN
biomedich-91	65	26	.	.	PUNCT
biomedich-91	66	1	group	group	PROPN
biomedich-91	66	2	g(mg	g(mg	PROPN
biomedich-91	66	3	/	/	SYM
biomedich-91	66	4	dl	dl	PROPN
biomedich-91	66	5	)	)	PUNCT
biomedich-91	66	6	tg(mg	tg(mg	PROPN
biomedich-91	66	7	/	/	SYM
biomedich-91	66	8	dl	dl	PROPN
biomedich-91	66	9	)	)	PUNCT
biomedich-91	66	10	tc(mg	tc(mg	PROPN
biomedich-91	66	11	/	/	SYM
biomedich-91	66	12	dl	dl	PROPN
biomedich-91	66	13	)	)	PUNCT
biomedich-91	66	14	hdlc(mg	hdlc(mg	PROPN
biomedich-91	66	15	/	/	SYM
biomedich-91	66	16	dl	dl	NOUN
biomedich-91	66	17	)	)	PUNCT
biomedich-91	66	18	ldlc(mg	ldlc(mg	PROPN
biomedich-91	66	19	/	/	SYM
biomedich-91	66	20	dl	dl	PROPN
biomedich-91	66	21	)	)	PUNCT
biomedich-91	66	22	a	a	DET
biomedich-91	66	23	95.0±6.41	95.0±6.41	NUM
biomedich-91	66	24	70.5±6.78	70.5±6.78	NUM
biomedich-91	66	25	110.1±10.8	110.1±10.8	ADJ
biomedich-91	66	26	30.7±3.44	30.7±3.44	NUM
biomedich-91	66	27	65.7±6.00	65.7±6.00	NUM
biomedich-91	66	28	b	b	NOUN
biomedich-91	66	29	90.7±	90.7±	NOUN
biomedich-91	66	30	7.85	7.85	NUM
biomedich-91	66	31	72.1±7.59	72.1±7.59	NUM
biomedich-91	66	32	106.8±10.3	106.8±10.3	NUM
biomedich-91	66	33	31.8±3.35	31.8±3.35	NUM
biomedich-91	66	34	61.6±5.32	61.6±5.32	NUM
biomedich-91	66	35	c	c	NOUN
biomedich-91	66	36	92.0±6.42	92.0±6.42	NUM
biomedich-91	66	37	74.9±6.70	74.9±6.70	NUM
biomedich-91	66	38	112.0±10.6	112.0±10.6	NOUN
biomedich-91	66	39	32.6±2.61	32.6±2.61	NUM
biomedich-91	66	40	64.5±6.42	64.5±6.42	NUM
biomedich-91	67	1	d	d	SYM
biomedich-91	67	2	100.9±9.19	100.9±9.19	NUM
biomedich-91	67	3	81.1±7.56	81.1±7.56	NUM
biomedich-91	67	4	110.3±11.1	110.3±11.1	NOUN
biomedich-91	67	5	32.4±2.63	32.4±2.63	NUM
biomedich-91	67	6	64.7±7.62	64.7±7.62	NUM
biomedich-91	67	7	n=6	n=6	NUM
biomedich-91	67	8	,	,	PUNCT
biomedich-91	67	9	data	datum	NOUN
biomedich-91	67	10	are	be	AUX
biomedich-91	67	11	expressed	express	VERB
biomedich-91	67	12	as	as	ADP
biomedich-91	67	13	mean	mean	PROPN
biomedich-91	67	14	±	±	NUM
biomedich-91	67	15	sem	sem	PROPN
biomedich-91	67	16	.	.	PUNCT
biomedich-91	67	17	table	table	NOUN
biomedich-91	67	18	3	3	NUM
biomedich-91	67	19	.	.	PUNCT
biomedich-91	67	20	effects	effect	NOUN
biomedich-91	67	21	of	of	ADP
biomedich-91	67	22	tramadol	tramadol	NOUN
biomedich-91	67	23	-	-	PUNCT
biomedich-91	67	24	diclofenac	diclofenac	NOUN
biomedich-91	67	25	on	on	ADP
biomedich-91	67	26	serum	serum	NOUN
biomedich-91	67	27	liver	liver	NOUN
biomedich-91	67	28	function	function	NOUN
biomedich-91	67	29	indices	index	NOUN
biomedich-91	67	30	of	of	ADP
biomedich-91	67	31	albino	albino	NOUN
biomedich-91	67	32	rats	rat	NOUN
biomedich-91	67	33	.	.	PUNCT
biomedich-91	68	1	group	group	NOUN
biomedich-91	68	2	ast(u	ast(u	PROPN
biomedich-91	68	3	/	/	SYM
biomedich-91	68	4	l	l	NOUN
biomedich-91	68	5	)	)	PUNCT
biomedich-91	68	6	alt(u	alt(u	PROPN
biomedich-91	68	7	/	/	SYM
biomedich-91	68	8	l	l	NOUN
biomedich-91	68	9	)	)	PUNCT
biomedich-91	68	10	alp(u	alp(u	PROPN
biomedich-91	68	11	/	/	SYM
biomedich-91	68	12	l	l	NOUN
biomedich-91	68	13	)	)	PUNCT
biomedich-91	68	14	ggt(u	ggt(u	PROPN
biomedich-91	68	15	/	/	SYM
biomedich-91	68	16	l	l	NOUN
biomedich-91	68	17	)	)	PUNCT
biomedich-91	68	18	ldh(u	ldh(u	NOUN
biomedich-91	68	19	/	/	SYM
biomedich-91	68	20	l	l	NOUN
biomedich-91	68	21	)	)	PUNCT
biomedich-91	68	22	cb(g	cb(g	PROPN
biomedich-91	68	23	/	/	SYM
biomedich-91	68	24	dl	dl	NOUN
biomedich-91	68	25	)	)	PUNCT
biomedich-91	68	26	tb(g	tb(g	PROPN
biomedich-91	68	27	/	/	SYM
biomedich-91	68	28	dl	dl	PROPN
biomedich-91	68	29	)	)	PUNCT
biomedich-91	68	30	a	a	DET
biomedich-91	68	31	41.5±5.57	41.5±5.57	NUM
biomedich-91	68	32	34.2±3.15	34.2±3.15	NUM
biomedich-91	68	33	42.3±3.56	42.3±3.56	NUM
biomedich-91	68	34	45.5±3.11	45.5±3.11	NUM
biomedich-91	68	35	0.75±1.53	0.75±1.53	NOUN
biomedich-91	68	36	2.66±0.18	2.66±0.18	NUM
biomedich-91	68	37	4.21±0.05	4.21±0.05	NOUN
biomedich-91	68	38	b	b	PROPN
biomedich-91	68	39	60.5±6.96a	60.5±6.96a	NUM
biomedich-91	68	40	55.1±4.06a	55.1±4.06a	NUM
biomedich-91	68	41	69.5±6.11a	69.5±6.11a	NUM
biomedich-91	68	42	66.0±6.01a	66.0±6.01a	NOUN
biomedich-91	68	43	1.60±0.71a	1.60±0.71a	NUM
biomedich-91	68	44	3.95±0.06a	3.95±0.06a	NUM
biomedich-91	68	45	6.6±0.02a	6.6±0.02a	NOUN
biomedich-91	68	46	c	c	PROPN
biomedich-91	68	47	89.3±6.33b	89.3±6.33b	NUM
biomedich-91	68	48	79.2±5.25b	79.2±5.25b	NUM
biomedich-91	68	49	87.7±7.71b	87.7±7.71b	NUM
biomedich-91	69	1	88.1±9.43b	88.1±9.43b	NUM
biomedich-91	69	2	2.67±0.52b	2.67±0.52b	NUM
biomedich-91	69	3	5.73±0.65b	5.73±0.65b	NUM
biomedich-91	69	4	9.8±0.06b	9.8±0.06b	PROPN
biomedich-91	69	5	d	d	NOUN
biomedich-91	69	6	220.6±10.7c	220.6±10.7c	NUM
biomedich-91	69	7	181.3±9.70c	181.3±9.70c	NUM
biomedich-91	69	8	211.3±9.37c	211.3±9.37c	NUM
biomedich-91	69	9	220.2±14.2c	220.2±14.2c	NUM
biomedich-91	70	1	6.21±0.37c	6.21±0.37c	NUM
biomedich-91	70	2	15.4±1.22c	15.4±1.22c	NUM
biomedich-91	70	3	22.8±0.76c	22.8±0.76c	NUM
biomedich-91	70	4	n=6	n=6	NUM
biomedich-91	70	5	,	,	PUNCT
biomedich-91	70	6	data	datum	NOUN
biomedich-91	70	7	are	be	AUX
biomedich-91	70	8	expressed	express	VERB
biomedich-91	70	9	as	as	ADP
biomedich-91	70	10	mean	mean	PROPN
biomedich-91	70	11	±	±	NUM
biomedich-91	70	12	sem	sem	PROPN
biomedich-91	70	13	,	,	PUNCT
biomedich-91	70	14	a	a	DET
biomedich-91	70	15	differ	differ	VERB
biomedich-91	70	16	significantly	significantly	ADV
biomedich-91	70	17	at	at	ADP
biomedich-91	70	18	p<0.05	p<0.05	NOUN
biomedich-91	70	19	when	when	SCONJ
biomedich-91	70	20	compared	compare	VERB
biomedich-91	70	21	to	to	ADP
biomedich-91	70	22	control	control	PROPN
biomedich-91	70	23	b	b	PROPN
biomedich-91	70	24	differ	differ	VERB
biomedich-91	70	25	significantly	significantly	ADV
biomedich-91	70	26	at	at	ADP
biomedich-91	70	27	p<0.01	p<0.01	PROPN
biomedich-91	70	28	when	when	SCONJ
biomedich-91	70	29	compared	compare	VERB
biomedich-91	70	30	to	to	ADP
biomedich-91	70	31	control	control	NOUN
biomedich-91	70	32	,	,	PUNCT
biomedich-91	70	33	c	c	PROPN
biomedich-91	70	34	differ	differ	VERB
biomedich-91	70	35	significantly	significantly	ADV
biomedich-91	70	36	at	at	ADP
biomedich-91	70	37	p<0.001	p<0.001	PUNCT
biomedich-91	70	38	when	when	SCONJ
biomedich-91	70	39	compared	compare	VERB
biomedich-91	70	40	to	to	ADP
biomedich-91	70	41	control	control	VERB
biomedich-91	70	42	.	.	PUNCT
biomedich-91	71	1	adikwu	adikwu	PROPN
biomedich-91	71	2	&	&	CCONJ
biomedich-91	71	3	nelson	nelson	PROPN
biomedich-91	71	4	–	–	PUNCT
biomedich-91	71	5	hepatotoxic	hepatotoxic	ADJ
biomedich-91	71	6	effect	effect	NOUN
biomedich-91	71	7	of	of	ADP
biomedich-91	71	8	tramadol	tramadol	NOUN
biomedich-91	71	9	-	-	PUNCT
biomedich-91	71	10	diclofenac	diclofenac	NOUN
biomedich-91	71	11	43	43	NUM
biomedich-91	71	12	table	table	NOUN
biomedich-91	71	13	4	4	NUM
biomedich-91	71	14	.	.	PUNCT
biomedich-91	71	15	effects	effect	NOUN
biomedich-91	71	16	of	of	ADP
biomedich-91	71	17	tramadol	tramadol	NOUN
biomedich-91	71	18	-	-	PUNCT
biomedich-91	71	19	diclofenac	diclofenac	NOUN
biomedich-91	71	20	on	on	ADP
biomedich-91	71	21	liver	liver	NOUN
biomedich-91	71	22	tissue	tissue	NOUN
biomedich-91	71	23	biochemical	biochemical	ADJ
biomedich-91	71	24	parameters	parameter	NOUN
biomedich-91	71	25	of	of	ADP
biomedich-91	71	26	albino	albino	NOUN
biomedich-91	71	27	rats	rat	NOUN
biomedich-91	71	28	.	.	PUNCT
biomedich-91	72	1	group	group	NOUN
biomedich-91	72	2	ast(u	ast(u	PROPN
biomedich-91	72	3	/	/	SYM
biomedich-91	72	4	l	l	NOUN
biomedich-91	72	5	)	)	PUNCT
biomedich-91	72	6	alt(u	alt(u	PROPN
biomedich-91	72	7	/	/	SYM
biomedich-91	72	8	l	l	NOUN
biomedich-91	72	9	)	)	PUNCT
biomedich-91	72	10	alp(u	alp(u	PROPN
biomedich-91	72	11	/	/	SYM
biomedich-91	72	12	l	l	NOUN
biomedich-91	72	13	)	)	PUNCT
biomedich-91	72	14	ggt(u	ggt(u	PROPN
biomedich-91	72	15	/	/	SYM
biomedich-91	72	16	l	l	NOUN
biomedich-91	72	17	)	)	PUNCT
biomedich-91	72	18	ldh(u	ldh(u	NOUN
biomedich-91	72	19	/	/	SYM
biomedich-91	72	20	l	l	NOUN
biomedich-91	72	21	)	)	PUNCT
biomedich-91	72	22	a	a	DET
biomedich-91	72	23	244.8±12.0	244.8±12.0	ADJ
biomedich-91	72	24	246.9±12.1	246.9±12.1	NUM
biomedich-91	72	25	247.2±12.3	247.2±12.3	NUM
biomedich-91	72	26	250.5±14.2	250.5±14.2	PROPN
biomedich-91	72	27	22.9±4.03	22.9±4.03	NUM
biomedich-91	72	28	b	b	NOUN
biomedich-91	72	29	373.8±	373.8±	NUM
biomedich-91	72	30	17.6a	17.6a	NUM
biomedich-91	72	31	374.6±20.4a	374.6±20.4a	NUM
biomedich-91	72	32	390.0±20.0a	390.0±20.0a	NUM
biomedich-91	72	33	399.0±17.4a	399.0±17.4a	NUM
biomedich-91	72	34	45.2±7.09a	45.2±7.09a	NOUN
biomedich-91	72	35	c	c	NOUN
biomedich-91	72	36	499.6±25.0b	499.6±25.0b	NOUN
biomedich-91	72	37	470.3±26.0b	470.3±26.0b	NUM
biomedich-91	73	1	488.4±23.4b	488.4±23.4b	NUM
biomedich-91	73	2	475.1±21.2b	475.1±21.2b	NUM
biomedich-91	73	3	68.1±8.16b	68.1±8.16b	NUM
biomedich-91	73	4	d	d	NOUN
biomedich-91	73	5	960.0±23.7c	960.0±23.7c	NUM
biomedich-91	73	6	983.3±41.8c	983.3±41.8c	NUM
biomedich-91	73	7	901.0±43.7c	901.0±43.7c	NUM
biomedich-91	73	8	888.2±30.6c	888.2±30.6c	NUM
biomedich-91	73	9	190.5±12.8c	190.5±12.8c	NUM
biomedich-91	73	10	n=6	n=6	NUM
biomedich-91	73	11	,	,	PUNCT
biomedich-91	73	12	data	datum	NOUN
biomedich-91	73	13	are	be	AUX
biomedich-91	73	14	expressed	express	VERB
biomedich-91	73	15	as	as	ADP
biomedich-91	73	16	mean	mean	PROPN
biomedich-91	73	17	±	±	NUM
biomedich-91	73	18	sem	sem	PROPN
biomedich-91	73	19	,	,	PUNCT
biomedich-91	73	20	a	a	DET
biomedich-91	73	21	differ	differ	VERB
biomedich-91	73	22	significantly	significantly	ADV
biomedich-91	73	23	at	at	ADP
biomedich-91	73	24	p<0.05	p<0.05	NOUN
biomedich-91	73	25	when	when	SCONJ
biomedich-91	73	26	compared	compare	VERB
biomedich-91	73	27	to	to	ADP
biomedich-91	73	28	control	control	PROPN
biomedich-91	73	29	b	b	PROPN
biomedich-91	73	30	differ	differ	VERB
biomedich-91	73	31	significantly	significantly	ADV
biomedich-91	73	32	at	at	ADP
biomedich-91	73	33	p<0.01	p<0.01	PROPN
biomedich-91	73	34	when	when	SCONJ
biomedich-91	73	35	compared	compare	VERB
biomedich-91	73	36	to	to	ADP
biomedich-91	73	37	control	control	NOUN
biomedich-91	73	38	,	,	PUNCT
biomedich-91	73	39	c	c	PROPN
biomedich-91	73	40	differ	differ	VERB
biomedich-91	73	41	significantly	significantly	ADV
biomedich-91	73	42	at	at	ADP
biomedich-91	73	43	p<0.001	p<0.001	PUNCT
biomedich-91	73	44	when	when	SCONJ
biomedich-91	73	45	compared	compare	VERB
biomedich-91	73	46	to	to	ADP
biomedich-91	73	47	control	control	NOUN
biomedich-91	73	48	table	table	NOUN
biomedich-91	73	49	5	5	NUM
biomedich-91	73	50	.	.	PUNCT
biomedich-91	73	51	effect	effect	NOUN
biomedich-91	73	52	of	of	ADP
biomedich-91	73	53	tramadol	tramadol	NOUN
biomedich-91	73	54	-	-	PUNCT
biomedich-91	73	55	diclofenac	diclofenac	NOUN
biomedich-91	73	56	on	on	ADP
biomedich-91	73	57	liver	liver	NOUN
biomedich-91	73	58	oxidative	oxidative	ADJ
biomedich-91	73	59	stress	stress	NOUN
biomedich-91	73	60	indices	index	NOUN
biomedich-91	73	61	of	of	ADP
biomedich-91	73	62	albino	albino	NOUN
biomedich-91	73	63	rats	rat	NOUN
biomedich-91	73	64	.	.	PUNCT
biomedich-91	74	1	group	group	PROPN
biomedich-91	74	2	mda	mda	PROPN
biomedich-91	74	3	(	(	PUNCT
biomedich-91	74	4	nmol	nmol	PROPN
biomedich-91	74	5	/	/	SYM
biomedich-91	74	6	mg	mg	PROPN
biomedich-91	74	7	protein	protein	NOUN
biomedich-91	74	8	)	)	PUNCT
biomedich-91	74	9	sod	sod	NOUN
biomedich-91	74	10	(	(	PUNCT
biomedich-91	74	11	u	u	NOUN
biomedich-91	74	12	/	/	SYM
biomedich-91	74	13	mg	mg	PROPN
biomedich-91	74	14	protein	protein	NOUN
biomedich-91	74	15	)	)	PUNCT
biomedich-91	74	16	cat	cat	NOUN
biomedich-91	74	17	(	(	PUNCT
biomedich-91	74	18	u	u	NOUN
biomedich-91	74	19	/	/	SYM
biomedich-91	74	20	mg	mg	PROPN
biomedich-91	74	21	protein	protein	NOUN
biomedich-91	74	22	)	)	PUNCT
biomedich-91	74	23	gsh	gsh	PROPN
biomedich-91	74	24	(	(	PUNCT
biomedich-91	74	25	µmol	µmol	PROPN
biomedich-91	74	26	/	/	SYM
biomedich-91	74	27	mg	mg	PROPN
biomedich-91	74	28	protein	protein	NOUN
biomedich-91	74	29	)	)	PUNCT
biomedich-91	74	30	gpx	gpx	NOUN
biomedich-91	74	31	(	(	PUNCT
biomedich-91	74	32	u	u	NOUN
biomedich-91	74	33	/	/	SYM
biomedich-91	74	34	mg	mg	PROPN
biomedich-91	74	35	protein	protein	NOUN
biomedich-91	74	36	)	)	PUNCT
biomedich-91	74	37	a	a	DET
biomedich-91	74	38	0.17±0.06	0.17±0.06	NOUN
biomedich-91	74	39	16.2±1.89	16.2±1.89	NUM
biomedich-91	74	40	26.4±2.77	26.4±2.77	NUM
biomedich-91	74	41	8.96±0.15	8.96±0.15	NUM
biomedich-91	74	42	11.7±0.16	11.7±0.16	NUM
biomedich-91	74	43	b	b	NOUN
biomedich-91	74	44	0.39±	0.39±	NUM
biomedich-91	74	45	0.04a	0.04a	PROPN
biomedich-91	74	46	11.6±0.15a	11.6±0.15a	NUM
biomedich-91	74	47	17.0±0.79a	17.0±0.79a	NUM
biomedich-91	74	48	5.02±0.32a	5.02±0.32a	NUM
biomedich-91	74	49	5.25±0.01a	5.25±0.01a	NOUN
biomedich-91	74	50	c	c	NOUN
biomedich-91	74	51	0.52±0.04b	0.52±0.04b	NUM
biomedich-91	74	52	9.98±0.04b	9.98±0.04b	NUM
biomedich-91	74	53	13.6±1.16b	13.6±1.16b	NUM
biomedich-91	74	54	3.91±0.73b	3.91±0.73b	NUM
biomedich-91	74	55	4.00±0.18b	4.00±0.18b	NOUN
biomedich-91	74	56	d	d	NOUN
biomedich-91	74	57	1.37±0.32c	1.37±0.32c	NUM
biomedich-91	74	58	3.63±0.06c	3.63±0.06c	NUM
biomedich-91	74	59	5.61±0.83c	5.61±0.83c	NUM
biomedich-91	74	60	1.30±0.22c	1.30±0.22c	NUM
biomedich-91	74	61	2.57±0.82c	2.57±0.82c	NUM
biomedich-91	74	62	n=6	n=6	NOUN
biomedich-91	74	63	,	,	PUNCT
biomedich-91	74	64	data	datum	NOUN
biomedich-91	74	65	are	be	AUX
biomedich-91	74	66	expressed	express	VERB
biomedich-91	74	67	as	as	ADP
biomedich-91	74	68	mean	mean	PROPN
biomedich-91	74	69	±	±	NUM
biomedich-91	74	70	sem	sem	PROPN
biomedich-91	74	71	,	,	PUNCT
biomedich-91	74	72	a	a	DET
biomedich-91	74	73	differ	differ	VERB
biomedich-91	74	74	significantly	significantly	ADV
biomedich-91	74	75	at	at	ADP
biomedich-91	74	76	p<0.05	p<0.05	NOUN
biomedich-91	74	77	when	when	SCONJ
biomedich-91	74	78	compared	compare	VERB
biomedich-91	74	79	to	to	ADP
biomedich-91	74	80	control	control	PROPN
biomedich-91	74	81	b	b	PROPN
biomedich-91	74	82	differ	differ	VERB
biomedich-91	74	83	significantly	significantly	ADV
biomedich-91	74	84	at	at	ADP
biomedich-91	74	85	p<0.01	p<0.01	PROPN
biomedich-91	74	86	when	when	SCONJ
biomedich-91	74	87	compared	compare	VERB
biomedich-91	74	88	to	to	ADP
biomedich-91	74	89	control	control	NOUN
biomedich-91	74	90	,	,	PUNCT
biomedich-91	74	91	c	c	PROPN
biomedich-91	74	92	differ	differ	VERB
biomedich-91	74	93	significantly	significantly	ADV
biomedich-91	74	94	at	at	ADP
biomedich-91	74	95	p<0.001	p<0.001	PUNCT
biomedich-91	74	96	when	when	SCONJ
biomedich-91	74	97	compared	compare	VERB
biomedich-91	74	98	to	to	PART
biomedich-91	74	99	control	control	VERB
biomedich-91	74	100	figure	figure	NOUN
biomedich-91	74	101	1	1	NUM
biomedich-91	74	102	.	.	PUNCT
biomedich-91	75	1	(	(	PUNCT
biomedich-91	75	2	a	a	DET
biomedich-91	75	3	-	-	PUNCT
biomedich-91	75	4	e	e	NOUN
biomedich-91	75	5	)	)	PUNCT
biomedich-91	75	6	showed	show	VERB
biomedich-91	75	7	the	the	DET
biomedich-91	75	8	liver	liver	NOUN
biomedich-91	75	9	of	of	ADP
biomedich-91	75	10	control	control	NOUN
biomedich-91	75	11	rat	rat	NOUN
biomedich-91	75	12	,	,	PUNCT
biomedich-91	75	13	rats	rat	NOUN
biomedich-91	75	14	treated	treat	VERB
biomedich-91	75	15	with	with	ADP
biomedich-91	75	16	diclofenac	diclofenac	NOUN
biomedich-91	75	17	,	,	PUNCT
biomedich-91	75	18	tramadol	tramadol	NOUN
biomedich-91	75	19	and	and	CCONJ
biomedich-91	75	20	diclofenac	diclofenac	NOUN
biomedich-91	75	21	-	-	PUNCT
biomedich-91	75	22	tramadol	tramadol	NOUN
biomedich-91	75	23	(	(	PUNCT
biomedich-91	75	24	h	h	NOUN
biomedich-91	75	25	&	&	CCONJ
biomedich-91	75	26	e	e	NOUN
biomedich-91	75	27	stain	stain	NOUN
biomedich-91	75	28	400x	400x	NUM
biomedich-91	75	29	)	)	PUNCT
biomedich-91	75	30	.	.	PUNCT
biomedich-91	76	1	(	(	PUNCT
biomedich-91	76	2	a	a	X
biomedich-91	76	3	):	):	PUNCT
biomedich-91	76	4	the	the	DET
biomedich-91	76	5	liver	liver	NOUN
biomedich-91	76	6	of	of	ADP
biomedich-91	76	7	control	control	NOUN
biomedich-91	76	8	rat	rat	NOUN
biomedich-91	76	9	showing	show	VERB
biomedich-91	76	10	normal	normal	ADJ
biomedich-91	76	11	hepatocytes	hepatocyte	NOUN
biomedich-91	76	12	(	(	PUNCT
biomedich-91	76	13	b	b	NOUN
biomedich-91	76	14	):	):	PUNCT
biomedich-91	76	15	liver	liver	NOUN
biomedich-91	76	16	of	of	ADP
biomedich-91	76	17	rat	rat	NOUN
biomedich-91	76	18	treated	treat	VERB
biomedich-91	76	19	with	with	ADP
biomedich-91	76	20	tramadol	tramadol	NOUN
biomedich-91	76	21	(	(	PUNCT
biomedich-91	76	22	12	12	NUM
biomedich-91	76	23	mg	mg	PROPN
biomedich-91	76	24	/	/	SYM
biomedich-91	76	25	kg	kg	PROPN
biomedich-91	76	26	/	/	SYM
biomedich-91	76	27	day	day	NOUN
biomedich-91	76	28	)	)	PUNCT
biomedich-91	76	29	showing	show	VERB
biomedich-91	76	30	hepatocyte	hepatocyte	NOUN
biomedich-91	76	31	necrosis	necrosis	NOUN
biomedich-91	76	32	(	(	PUNCT
biomedich-91	76	33	c	c	NOUN
biomedich-91	76	34	):	):	PUNCT
biomedich-91	76	35	liver	liver	NOUN
biomedich-91	76	36	of	of	ADP
biomedich-91	76	37	rat	rat	NOUN
biomedich-91	76	38	treated	treat	VERB
biomedich-91	76	39	with	with	ADP
biomedich-91	76	40	diclofenac	diclofenac	NOUN
biomedich-91	76	41	(	(	PUNCT
biomedich-91	76	42	6	6	NUM
biomedich-91	76	43	mg	mg	PROPN
biomedich-91	76	44	/	/	SYM
biomedich-91	76	45	kg	kg	PROPN
biomedich-91	76	46	/	/	SYM
biomedich-91	76	47	day	day	NOUN
biomedich-91	76	48	)	)	PUNCT
biomedich-91	76	49	showing	show	VERB
biomedich-91	76	50	hepatocyte	hepatocyte	NOUN
biomedich-91	76	51	necrosis	necrosis	NOUN
biomedich-91	76	52	.	.	PUNCT
biomedich-91	77	1	(	(	PUNCT
biomedich-91	77	2	d	d	NOUN
biomedich-91	77	3	):	):	PUNCT
biomedich-91	77	4	liver	liver	NOUN
biomedich-91	77	5	of	of	ADP
biomedich-91	77	6	rat	rat	NOUN
biomedich-91	77	7	treated	treat	VERB
biomedich-91	77	8	with	with	ADP
biomedich-91	77	9	diclofenac	diclofenac	NOUN
biomedich-91	77	10	-	-	PUNCT
biomedich-91	77	11	tramadol	tramadol	NOUN
biomedich-91	77	12	showing	show	VERB
biomedich-91	77	13	hepatocyte	hepatocyte	NOUN
biomedich-91	77	14	necrosis	necrosis	NOUN
biomedich-91	77	15	results	result	VERB
biomedich-91	77	16	the	the	DET
biomedich-91	77	17	effects	effect	NOUN
biomedich-91	77	18	of	of	ADP
biomedich-91	77	19	tramadol	tramadol	NOUN
biomedich-91	77	20	-	-	PUNCT
biomedich-91	77	21	diclofenac	diclofenac	NOUN
biomedich-91	77	22	were	be	AUX
biomedich-91	77	23	not	not	PART
biomedich-91	77	24	significant	significant	ADJ
biomedich-91	77	25	(	(	PUNCT
biomedich-91	77	26	p>0.05	p>0.05	NOUN
biomedich-91	77	27	)	)	PUNCT
biomedich-91	77	28	on	on	ADP
biomedich-91	77	29	the	the	DET
biomedich-91	77	30	body	body	NOUN
biomedich-91	77	31	and	and	CCONJ
biomedich-91	77	32	liver	liver	NOUN
biomedich-91	77	33	weights	weight	NOUN
biomedich-91	77	34	of	of	ADP
biomedich-91	77	35	treated	treat	VERB
biomedich-91	77	36	rats	rat	NOUN
biomedich-91	77	37	when	when	SCONJ
biomedich-91	77	38	compared	compare	VERB
biomedich-91	77	39	to	to	ADP
biomedich-91	77	40	control	control	NOUN
biomedich-91	77	41	(	(	PUNCT
biomedich-91	77	42	table	table	NOUN
biomedich-91	77	43	1	1	NUM
biomedich-91	77	44	)	)	PUNCT
biomedich-91	77	45	.	.	PUNCT
biomedich-91	78	1	also	also	ADV
biomedich-91	78	2	,	,	PUNCT
biomedich-91	78	3	serum	serum	PROPN
biomedich-91	78	4	tc	tc	PROPN
biomedich-91	78	5	,	,	PUNCT
biomedich-91	78	6	tg	tg	PROPN
biomedich-91	78	7	,	,	PUNCT
biomedich-91	78	8	hdl	hdl	PROPN
biomedich-91	78	9	cholesterol	cholesterol	PROPN
biomedich-91	78	10	,	,	PUNCT
biomedich-91	78	11	ldl	ldl	NOUN
biomedich-91	78	12	cholesterol	cholesterol	NOUN
biomedich-91	78	13	and	and	CCONJ
biomedich-91	78	14	blood	blood	NOUN
biomedich-91	78	15	g	g	NOUN
biomedich-91	78	16	levels	level	NOUN
biomedich-91	78	17	were	be	AUX
biomedich-91	78	18	normal	normal	ADJ
biomedich-91	78	19	(	(	PUNCT
biomedich-91	78	20	p>0.05	p>0.05	NOUN
biomedich-91	78	21	)	)	PUNCT
biomedich-91	78	22	in	in	ADP
biomedich-91	78	23	rats	rat	NOUN
biomedich-91	78	24	treated	treat	VERB
biomedich-91	78	25	with	with	ADP
biomedich-91	78	26	tramadoldiclofenac	tramadoldiclofenac	NOUN
biomedich-91	78	27	when	when	SCONJ
biomedich-91	78	28	compared	compare	VERB
biomedich-91	78	29	to	to	ADP
biomedich-91	78	30	control	control	NOUN
biomedich-91	78	31	(	(	PUNCT
biomedich-91	78	32	table	table	NOUN
biomedich-91	78	33	2	2	NUM
biomedich-91	78	34	)	)	PUNCT
biomedich-91	78	35	.	.	PUNCT
biomedich-91	79	1	serum	serum	PROPN
biomedich-91	79	2	ast	ast	PROPN
biomedich-91	79	3	,	,	PUNCT
biomedich-91	79	4	alp	alp	PROPN
biomedich-91	79	5	,	,	PUNCT
biomedich-91	79	6	alt	alt	ADJ
biomedich-91	79	7	,	,	PUNCT
biomedich-91	79	8	ggt	ggt	NOUN
biomedich-91	79	9	,	,	PUNCT
biomedich-91	79	10	ldh	ldh	PROPN
biomedich-91	79	11	,	,	PUNCT
biomedich-91	79	12	ct	ct	NOUN
biomedich-91	79	13	and	and	CCONJ
biomedich-91	79	14	tb	tb	ADP
biomedich-91	79	15	levels	level	NOUN
biomedich-91	79	16	were	be	AUX
biomedich-91	79	17	significantly	significantly	ADV
biomedich-91	79	18	increased	increase	VERB
biomedich-91	79	19	in	in	ADP
biomedich-91	79	20	tramadol	tramadol	NOUN
biomedich-91	79	21	(	(	PUNCT
biomedich-91	79	22	p<0.05	p<0.05	NOUN
biomedich-91	79	23	)	)	PUNCT
biomedich-91	79	24	and	and	CCONJ
biomedich-91	79	25	diclofenac	diclofenac	NOUN
biomedich-91	79	26	(	(	PUNCT
biomedich-91	79	27	p<0.01	p<0.01	PROPN
biomedich-91	79	28	)	)	PUNCT
biomedich-91	79	29	treated	treat	VERB
biomedich-91	79	30	rats	rat	NOUN
biomedich-91	79	31	when	when	SCONJ
biomedich-91	79	32	compared	compare	VERB
biomedich-91	79	33	to	to	ADP
biomedich-91	79	34	control	control	VERB
biomedich-91	79	35	.	.	PUNCT
biomedich-91	80	1	however	however	ADV
biomedich-91	80	2	,	,	PUNCT
biomedich-91	80	3	elevations	elevation	NOUN
biomedich-91	80	4	in	in	ADP
biomedich-91	80	5	the	the	DET
biomedich-91	80	6	serum	serum	NOUN
biomedich-91	80	7	levels	level	NOUN
biomedich-91	80	8	of	of	ADP
biomedich-91	80	9	the	the	DET
biomedich-91	80	10	aforementioned	aforementioned	ADJ
biomedich-91	80	11	parameters	parameter	NOUN
biomedich-91	80	12	were	be	AUX
biomedich-91	80	13	most	most	ADV
biomedich-91	80	14	significant	significant	ADJ
biomedich-91	80	15	(	(	PUNCT
biomedich-91	80	16	p<0.001	p<0.001	X
biomedich-91	80	17	)	)	PUNCT
biomedich-91	80	18	in	in	ADP
biomedich-91	80	19	rats	rat	NOUN
biomedich-91	80	20	treated	treat	VERB
biomedich-91	80	21	with	with	ADP
biomedich-91	80	22	tramadol	tramadol	NOUN
biomedich-91	80	23	-	-	PUNCT
biomedich-91	80	24	diclofenac	diclofenac	NOUN
biomedich-91	80	25	when	when	SCONJ
biomedich-91	80	26	compared	compare	VERB
biomedich-91	80	27	to	to	ADP
biomedich-91	80	28	control	control	NOUN
biomedich-91	80	29	(	(	PUNCT
biomedich-91	80	30	table	table	NOUN
biomedich-91	80	31	3	3	NUM
biomedich-91	80	32	)	)	PUNCT
biomedich-91	80	33	.	.	PUNCT
biomedich-91	81	1	the	the	DET
biomedich-91	81	2	liver	liver	NOUN
biomedich-91	81	3	levels	level	NOUN
biomedich-91	81	4	of	of	ADP
biomedich-91	81	5	ast	ast	PROPN
biomedich-91	81	6	,	,	PUNCT
biomedich-91	81	7	alp	alp	PROPN
biomedich-91	81	8	,	,	PUNCT
biomedich-91	81	9	alt	alt	ADJ
biomedich-91	81	10	,	,	PUNCT
biomedich-91	81	11	ggt	ggt	PROPN
biomedich-91	81	12	and	and	CCONJ
biomedich-91	81	13	ldh	ldh	PROPN
biomedich-91	81	14	were	be	AUX
biomedich-91	81	15	significantly	significantly	ADV
biomedich-91	81	16	increased	increase	VERB
biomedich-91	81	17	in	in	ADP
biomedich-91	81	18	rats	rat	NOUN
biomedich-91	81	19	treated	treat	VERB
biomedich-91	81	20	with	with	ADP
biomedich-91	81	21	tramadol	tramadol	NOUN
biomedich-91	81	22	(	(	PUNCT
biomedich-91	81	23	p<0.05	p<0.05	NOUN
biomedich-91	81	24	)	)	PUNCT
biomedich-91	81	25	and	and	CCONJ
biomedich-91	81	26	diclofenac	diclofenac	NOUN
biomedich-91	81	27	(	(	PUNCT
biomedich-91	81	28	p<0.01	p<0.01	PROPN
biomedich-91	81	29	)	)	PUNCT
biomedich-91	81	30	,	,	PUNCT
biomedich-91	81	31	but	but	CCONJ
biomedich-91	81	32	significant	significant	ADJ
biomedich-91	81	33	increases	increase	NOUN
biomedich-91	81	34	occurred	occur	VERB
biomedich-91	81	35	at	at	ADP
biomedich-91	81	36	p<0.001	p<0.001	VERB
biomedich-91	81	37	in	in	ADP
biomedich-91	81	38	rats	rat	NOUN
biomedich-91	81	39	treated	treat	VERB
biomedich-91	81	40	with	with	ADP
biomedich-91	81	41	tramadol	tramadol	NOUN
biomedich-91	81	42	-	-	PUNCT
biomedich-91	81	43	diclofenac	diclofenac	NOUN
biomedich-91	81	44	when	when	SCONJ
biomedich-91	81	45	compared	compare	VERB
biomedich-91	81	46	to	to	ADP
biomedich-91	81	47	control	control	NOUN
biomedich-91	81	48	(	(	PUNCT
biomedich-91	81	49	table	table	NOUN
biomedich-91	81	50	4	4	NUM
biomedich-91	81	51	)	)	PUNCT
biomedich-91	81	52	.	.	PUNCT
biomedich-91	82	1	furthermore	furthermore	ADV
biomedich-91	82	2	,	,	PUNCT
biomedich-91	82	3	liver	liver	NOUN
biomedich-91	82	4	sod	sod	NOUN
biomedich-91	82	5	,	,	PUNCT
biomedich-91	82	6	cat	cat	NOUN
biomedich-91	82	7	,	,	PUNCT
biomedich-91	82	8	gsh	gsh	PROPN
biomedich-91	82	9	and	and	CCONJ
biomedich-91	82	10	gpx	gpx	PROPN
biomedich-91	82	11	levels	level	NOUN
biomedich-91	82	12	were	be	AUX
biomedich-91	82	13	significantly	significantly	ADV
biomedich-91	82	14	decreased	decrease	VERB
biomedich-91	82	15	whereas	whereas	SCONJ
biomedich-91	82	16	mda	mda	PROPN
biomedich-91	82	17	levels	level	NOUN
biomedich-91	82	18	were	be	AUX
biomedich-91	82	19	significantly	significantly	ADV
biomedich-91	82	20	increased	increase	VERB
biomedich-91	82	21	in	in	ADP
biomedich-91	82	22	rats	rat	NOUN
biomedich-91	82	23	treated	treat	VERB
biomedich-91	82	24	with	with	ADP
biomedich-91	82	25	tramadol	tramadol	NOUN
biomedich-91	82	26	(	(	PUNCT
biomedich-91	82	27	p<0.05	p<0.05	NOUN
biomedich-91	82	28	)	)	PUNCT
biomedich-91	82	29	,	,	PUNCT
biomedich-91	82	30	diclofenac	diclofenac	NOUN
biomedich-91	82	31	(	(	PUNCT
biomedich-91	82	32	p<0.01	p<0.01	PROPN
biomedich-91	82	33	)	)	PUNCT
biomedich-91	82	34	and	and	CCONJ
biomedich-91	82	35	tramadol	tramadol	NOUN
biomedich-91	82	36	-	-	PUNCT
biomedich-91	82	37	diclofenac	diclofenac	NOUN
biomedich-91	82	38	(	(	PUNCT
biomedich-91	82	39	p<0.001	p<0.001	PROPN
biomedich-91	82	40	)	)	PUNCT
biomedich-91	82	41	when	when	SCONJ
biomedich-91	82	42	compared	compare	VERB
biomedich-91	82	43	to	to	ADP
biomedich-91	82	44	control	control	NOUN
biomedich-91	82	45	(	(	PUNCT
biomedich-91	82	46	table	table	NOUN
biomedich-91	82	47	5	5	NUM
biomedich-91	82	48	)	)	PUNCT
biomedich-91	82	49	.	.	PUNCT
biomedich-91	83	1	the	the	DET
biomedich-91	83	2	liver	liver	NOUN
biomedich-91	83	3	of	of	ADP
biomedich-91	83	4	control	control	NOUN
biomedich-91	83	5	rat	rat	NOUN
biomedich-91	83	6	showed	show	VERB
biomedich-91	83	7	normal	normal	ADJ
biomedich-91	83	8	hepatocytes	hepatocyte	NOUN
biomedich-91	83	9	(	(	PUNCT
biomedich-91	83	10	fig	fig	NOUN
biomedich-91	83	11	a	a	NOUN
biomedich-91	83	12	)	)	PUNCT
biomedich-91	83	13	whereas	whereas	SCONJ
biomedich-91	83	14	the	the	DET
biomedich-91	83	15	liver	liver	NOUN
biomedich-91	83	16	of	of	ADP
biomedich-91	83	17	rat	rat	NOUN
biomedich-91	83	18	treated	treat	VERB
biomedich-91	83	19	with	with	ADP
biomedich-91	83	20	tramadol	tramadol	NOUN
biomedich-91	83	21	and	and	CCONJ
biomedich-91	83	22	diclofenac	diclofenac	NOUN
biomedich-91	83	23	showed	show	VERB
biomedich-91	83	24	hepatocyte	hepatocyte	NOUN
biomedich-91	83	25	necroses	necrose	NOUN
biomedich-91	83	26	respectively	respectively	ADV
biomedich-91	83	27	(	(	PUNCT
biomedich-91	83	28	fig	fig	NOUN
biomedich-91	83	29	b	b	NOUN
biomedich-91	83	30	and	and	CCONJ
biomedich-91	83	31	c	c	NOUN
biomedich-91	83	32	)	)	PUNCT
biomedich-91	83	33	.	.	PUNCT
biomedich-91	84	1	the	the	DET
biomedich-91	84	2	liver	liver	NOUN
biomedich-91	84	3	of	of	ADP
biomedich-91	84	4	rats	rat	NOUN
biomedich-91	84	5	treated	treat	VERB
biomedich-91	84	6	with	with	ADP
biomedich-91	84	7	tramadol	tramadol	NOUN
biomedich-91	84	8	-	-	PUNCT
biomedich-91	84	9	diclofenac	diclofenac	NOUN
biomedich-91	84	10	also	also	ADV
biomedich-91	84	11	showed	show	VERB
biomedich-91	84	12	hepatocyte	hepatocyte	NOUN
biomedich-91	84	13	necrosis	necrosis	NOUN
biomedich-91	84	14	(	(	PUNCT
biomedich-91	84	15	fig	fig	NOUN
biomedich-91	84	16	d	d	NOUN
biomedich-91	84	17	)	)	PUNCT
biomedich-91	84	18	.	.	PUNCT
biomedich-91	85	1	discussion	discussion	NOUN
biomedich-91	85	2	the	the	DET
biomedich-91	85	3	present	present	ADJ
biomedich-91	85	4	study	study	NOUN
biomedich-91	85	5	evaluated	evaluate	VERB
biomedich-91	85	6	the	the	DET
biomedich-91	85	7	hepatotoxic	hepatotoxic	ADJ
biomedich-91	85	8	effect	effect	NOUN
biomedich-91	85	9	of	of	ADP
biomedich-91	85	10	tramadol	tramadol	NOUN
biomedich-91	85	11	-	-	PUNCT
biomedich-91	85	12	diclofenac	diclofenac	NOUN
biomedich-91	85	13	in	in	ADP
biomedich-91	85	14	a	a	DET
biomedich-91	85	15	rat	rat	NOUN
biomedich-91	85	16	model	model	NOUN
biomedich-91	85	17	.	.	PUNCT
biomedich-91	86	1	the	the	DET
biomedich-91	86	2	indices	index	NOUN
biomedich-91	86	3	evaluated	evaluate	VERB
biomedich-91	86	4	in	in	ADP
biomedich-91	86	5	this	this	DET
biomedich-91	86	6	study	study	NOUN
biomedich-91	86	7	are	be	AUX
biomedich-91	86	8	useful	useful	ADJ
biomedich-91	86	9	parameters	parameter	NOUN
biomedich-91	86	10	to	to	PART
biomedich-91	86	11	indicate	indicate	VERB
biomedich-91	86	12	impairment	impairment	NOUN
biomedich-91	86	13	in	in	ADP
biomedich-91	86	14	the	the	DET
biomedich-91	86	15	functional	functional	ADJ
biomedich-91	86	16	capacity	capacity	NOUN
biomedich-91	86	17	of	of	ADP
biomedich-91	86	18	the	the	DET
biomedich-91	86	19	liver	liver	NOUN
biomedich-91	86	20	.	.	PUNCT
biomedich-91	87	1	analysis	analysis	NOUN
biomedich-91	87	2	of	of	ADP
biomedich-91	87	3	organ	organ	NOUN
biomedich-91	87	4	weight	weight	NOUN
biomedich-91	87	5	in	in	ADP
biomedich-91	87	6	toxicology	toxicology	NOUN
biomedich-91	87	7	studies	study	NOUN
biomedich-91	87	8	is	be	AUX
biomedich-91	87	9	an	an	DET
biomedich-91	87	10	important	important	ADJ
biomedich-91	87	11	endpoint	endpoint	NOUN
biomedich-91	87	12	for	for	ADP
biomedich-91	87	13	the	the	DET
biomedich-91	87	14	identification	identification	NOUN
biomedich-91	87	15	of	of	ADP
biomedich-91	87	16	potentially	potentially	ADV
biomedich-91	87	17	harmful	harmful	ADJ
biomedich-91	87	18	effects	effect	NOUN
biomedich-91	87	19	of	of	ADP
biomedich-91	87	20	chemicals	chemical	NOUN
biomedich-91	87	21	.	.	PUNCT
biomedich-91	88	1	it	it	PRON
biomedich-91	88	2	is	be	AUX
biomedich-91	88	3	one	one	NUM
biomedich-91	88	4	of	of	ADP
biomedich-91	88	5	the	the	DET
biomedich-91	88	6	most	most	ADV
biomedich-91	88	7	sensitive	sensitive	ADJ
biomedich-91	88	8	drug	drug	NOUN
biomedich-91	88	9	toxicity	toxicity	NOUN
biomedich-91	88	10	indicators	indicator	NOUN
biomedich-91	88	11	,	,	PUNCT
biomedich-91	88	12	and	and	CCONJ
biomedich-91	88	13	its	its	PRON
biomedich-91	88	14	changes	change	NOUN
biomedich-91	88	15	often	often	ADV
biomedich-91	88	16	precede	precede	VERB
biomedich-91	88	17	morphological	morphological	ADJ
biomedich-91	88	18	changes	change	NOUN
biomedich-91	88	19	(	(	PUNCT
biomedich-91	88	20	bailey	bailey	PROPN
biomedich-91	88	21	et	et	PROPN
biomedich-91	88	22	al	al	PROPN
biomedich-91	88	23	.	.	PROPN
biomedich-91	88	24	,	,	PUNCT
biomedich-91	88	25	2004	2004	NUM
biomedich-91	88	26	)	)	PUNCT
biomedich-91	88	27	.	.	PUNCT
biomedich-91	89	1	in	in	ADP
biomedich-91	89	2	44	44	NUM
biomedich-91	89	3	biology	biology	NOUN
biomedich-91	89	4	,	,	PUNCT
biomedich-91	89	5	medicine	medicine	NOUN
biomedich-91	89	6	,	,	PUNCT
biomedich-91	89	7	&	&	CCONJ
biomedich-91	89	8	natural	natural	ADJ
biomedich-91	89	9	product	product	NOUN
biomedich-91	89	10	chemistry	chemistry	NOUN
biomedich-91	89	11	8	8	NUM
biomedich-91	89	12	(	(	PUNCT
biomedich-91	89	13	2	2	NUM
biomedich-91	89	14	)	)	PUNCT
biomedich-91	89	15	,	,	PUNCT
biomedich-91	89	16	2019	2019	NUM
biomedich-91	89	17	:	:	PUNCT
biomedich-91	89	18	41	41	NUM
biomedich-91	89	19	-	-	SYM
biomedich-91	89	20	45	45	NUM
biomedich-91	89	21	the	the	DET
biomedich-91	89	22	present	present	ADJ
biomedich-91	89	23	study	study	NOUN
biomedich-91	89	24	,	,	PUNCT
biomedich-91	89	25	tramadol	tramadol	NOUN
biomedich-91	89	26	-	-	PUNCT
biomedich-91	89	27	diclofenac	diclofenac	NOUN
biomedich-91	89	28	had	have	VERB
biomedich-91	89	29	no	no	DET
biomedich-91	89	30	effects	effect	NOUN
biomedich-91	89	31	on	on	ADP
biomedich-91	89	32	the	the	DET
biomedich-91	89	33	body	body	NOUN
biomedich-91	89	34	and	and	CCONJ
biomedich-91	89	35	liver	liver	NOUN
biomedich-91	89	36	weights	weight	NOUN
biomedich-91	89	37	of	of	ADP
biomedich-91	89	38	treated	treat	VERB
biomedich-91	89	39	rats	rat	NOUN
biomedich-91	89	40	.	.	PUNCT
biomedich-91	90	1	serum	serum	PROPN
biomedich-91	90	2	alp	alp	PROPN
biomedich-91	90	3	,	,	PUNCT
biomedich-91	90	4	ast	ast	PROPN
biomedich-91	90	5	,	,	PUNCT
biomedich-91	90	6	alt	alt	ADJ
biomedich-91	90	7	,	,	PUNCT
biomedich-91	90	8	ggt	ggt	NOUN
biomedich-91	90	9	,	,	PUNCT
biomedich-91	90	10	and	and	CCONJ
biomedich-91	90	11	ldh	ldh	NOUN
biomedich-91	90	12	are	be	AUX
biomedich-91	90	13	excellent	excellent	ADJ
biomedich-91	90	14	biomarkers	biomarker	NOUN
biomedich-91	90	15	of	of	ADP
biomedich-91	90	16	hepatocellular	hepatocellular	ADJ
biomedich-91	90	17	injury	injury	NOUN
biomedich-91	90	18	.	.	PUNCT
biomedich-91	91	1	ast	ast	VERB
biomedich-91	91	2	and	and	CCONJ
biomedich-91	91	3	alt	alt	VERB
biomedich-91	91	4	participate	participate	VERB
biomedich-91	91	5	in	in	ADP
biomedich-91	91	6	gluconeogenesis	gluconeogenesis	NOUN
biomedich-91	91	7	by	by	ADP
biomedich-91	91	8	catalyzing	catalyze	VERB
biomedich-91	91	9	the	the	DET
biomedich-91	91	10	transfer	transfer	NOUN
biomedich-91	91	11	of	of	ADP
biomedich-91	91	12	amino	amino	ADJ
biomedich-91	91	13	groups	group	NOUN
biomedich-91	91	14	from	from	ADP
biomedich-91	91	15	aspartic	aspartic	ADJ
biomedich-91	91	16	acid	acid	NOUN
biomedich-91	91	17	or	or	CCONJ
biomedich-91	91	18	alanine	alanine	NOUN
biomedich-91	91	19	to	to	PART
biomedich-91	91	20	ketoglutaric	ketoglutaric	NOUN
biomedich-91	91	21	acid	acid	PROPN
biomedich-91	91	22	to	to	PART
biomedich-91	91	23	produce	produce	VERB
biomedich-91	91	24	oxaloacetic	oxaloacetic	ADJ
biomedich-91	91	25	acid	acid	NOUN
biomedich-91	91	26	and	and	CCONJ
biomedich-91	91	27	pyruvic	pyruvic	ADJ
biomedich-91	91	28	acid	acid	NOUN
biomedich-91	91	29	respectively	respectively	ADV
biomedich-91	91	30	.	.	PUNCT
biomedich-91	92	1	ast	ast	PROPN
biomedich-91	92	2	is	be	AUX
biomedich-91	92	3	present	present	ADJ
biomedich-91	92	4	in	in	ADP
biomedich-91	92	5	cytosolic	cytosolic	ADJ
biomedich-91	92	6	and	and	CCONJ
biomedich-91	92	7	mitochondrial	mitochondrial	ADJ
biomedich-91	92	8	isoenzymes	isoenzyme	NOUN
biomedich-91	92	9	and	and	CCONJ
biomedich-91	92	10	is	be	AUX
biomedich-91	92	11	found	find	VERB
biomedich-91	92	12	in	in	ADP
biomedich-91	92	13	the	the	DET
biomedich-91	92	14	liver	liver	NOUN
biomedich-91	92	15	while	while	SCONJ
biomedich-91	92	16	alt	alt	ADJ
biomedich-91	92	17	,	,	PUNCT
biomedich-91	92	18	a	a	DET
biomedich-91	92	19	cytosolic	cytosolic	ADJ
biomedich-91	92	20	enzyme	enzyme	NOUN
biomedich-91	92	21	is	be	AUX
biomedich-91	92	22	found	find	VERB
biomedich-91	92	23	in	in	ADP
biomedich-91	92	24	its	its	PRON
biomedich-91	92	25	highest	high	ADJ
biomedich-91	92	26	concentration	concentration	NOUN
biomedich-91	92	27	in	in	ADP
biomedich-91	92	28	the	the	DET
biomedich-91	92	29	liver	liver	NOUN
biomedich-91	92	30	and	and	CCONJ
biomedich-91	92	31	is	be	AUX
biomedich-91	92	32	more	more	ADV
biomedich-91	92	33	specific	specific	ADJ
biomedich-91	92	34	to	to	ADP
biomedich-91	92	35	the	the	DET
biomedich-91	92	36	liver	liver	NOUN
biomedich-91	92	37	.	.	PUNCT
biomedich-91	93	1	alp	alp	PROPN
biomedich-91	93	2	is	be	AUX
biomedich-91	93	3	found	find	VERB
biomedich-91	93	4	histochemically	histochemically	ADV
biomedich-91	93	5	in	in	ADP
biomedich-91	93	6	the	the	DET
biomedich-91	93	7	microvilli	microvilli	NOUN
biomedich-91	93	8	of	of	ADP
biomedich-91	93	9	bile	bile	NOUN
biomedich-91	93	10	canaliculi	canaliculus	NOUN
biomedich-91	93	11	and	and	CCONJ
biomedich-91	93	12	on	on	ADP
biomedich-91	93	13	the	the	DET
biomedich-91	93	14	sinusoidal	sinusoidal	ADJ
biomedich-91	93	15	surface	surface	NOUN
biomedich-91	93	16	of	of	ADP
biomedich-91	93	17	hepatocytes	hepatocyte	NOUN
biomedich-91	93	18	(	(	PUNCT
biomedich-91	93	19	rosalki	rosalki	NOUN
biomedich-91	93	20	and	and	CCONJ
biomedich-91	93	21	mcintyre	mcintyre	PROPN
biomedich-91	93	22	,	,	PUNCT
biomedich-91	93	23	1999	1999	NUM
biomedich-91	93	24	)	)	PUNCT
biomedich-91	93	25	.	.	PUNCT
biomedich-91	94	1	ggt	ggt	NOUN
biomedich-91	94	2	is	be	AUX
biomedich-91	94	3	a	a	DET
biomedich-91	94	4	microsomal	microsomal	ADJ
biomedich-91	94	5	enzyme	enzyme	NOUN
biomedich-91	94	6	that	that	PRON
biomedich-91	94	7	is	be	AUX
biomedich-91	94	8	abundant	abundant	ADJ
biomedich-91	94	9	in	in	ADP
biomedich-91	94	10	hepatocytes	hepatocyte	NOUN
biomedich-91	94	11	and	and	CCONJ
biomedich-91	94	12	biliary	biliary	ADJ
biomedich-91	94	13	epithelial	epithelial	ADJ
biomedich-91	94	14	cells	cell	NOUN
biomedich-91	94	15	.	.	PUNCT
biomedich-91	95	1	it	it	PRON
biomedich-91	95	2	is	be	AUX
biomedich-91	95	3	involved	involve	VERB
biomedich-91	95	4	in	in	ADP
biomedich-91	95	5	the	the	DET
biomedich-91	95	6	transfer	transfer	NOUN
biomedich-91	95	7	of	of	ADP
biomedich-91	95	8	γglutamyl	γglutamyl	NOUN
biomedich-91	95	9	groups	group	NOUN
biomedich-91	95	10	from	from	ADP
biomedich-91	95	11	peptides	peptide	NOUN
biomedich-91	95	12	to	to	ADP
biomedich-91	95	13	amino	amino	ADJ
biomedich-91	95	14	acids	acid	NOUN
biomedich-91	95	15	and	and	CCONJ
biomedich-91	95	16	the	the	DET
biomedich-91	95	17	metabolism	metabolism	NOUN
biomedich-91	95	18	of	of	ADP
biomedich-91	95	19	glutathione	glutathione	NOUN
biomedich-91	95	20	conjugates	conjugate	NOUN
biomedich-91	95	21	(	(	PUNCT
biomedich-91	95	22	friedman	friedman	PROPN
biomedich-91	95	23	et	et	PROPN
biomedich-91	95	24	al	al	PROPN
biomedich-91	95	25	.	.	PROPN
biomedich-91	95	26	,	,	PUNCT
biomedich-91	95	27	1996	1996	NUM
biomedich-91	95	28	)	)	PUNCT
biomedich-91	95	29	.	.	PUNCT
biomedich-91	96	1	these	these	DET
biomedich-91	96	2	liver	liver	NOUN
biomedich-91	96	3	biomarkers	biomarker	NOUN
biomedich-91	96	4	are	be	AUX
biomedich-91	96	5	usually	usually	ADV
biomedich-91	96	6	released	release	VERB
biomedich-91	96	7	into	into	ADP
biomedich-91	96	8	circulation	circulation	NOUN
biomedich-91	96	9	causing	cause	VERB
biomedich-91	96	10	elevated	elevated	ADJ
biomedich-91	96	11	serum	serum	NOUN
biomedich-91	96	12	levels	level	NOUN
biomedich-91	96	13	with	with	ADP
biomedich-91	96	14	the	the	DET
biomedich-91	96	15	advent	advent	NOUN
biomedich-91	96	16	of	of	ADP
biomedich-91	96	17	hepatocellular	hepatocellular	ADJ
biomedich-91	96	18	injury	injury	NOUN
biomedich-91	96	19	(	(	PUNCT
biomedich-91	96	20	yousef	yousef	PROPN
biomedich-91	96	21	et	et	PROPN
biomedich-91	96	22	al	al	PROPN
biomedich-91	96	23	.	.	PROPN
biomedich-91	96	24	,	,	PUNCT
biomedich-91	96	25	2010	2010	NUM
biomedich-91	96	26	)	)	PUNCT
biomedich-91	96	27	.	.	PUNCT
biomedich-91	97	1	this	this	DET
biomedich-91	97	2	study	study	NOUN
biomedich-91	97	3	observed	observe	VERB
biomedich-91	97	4	elevated	elevated	ADJ
biomedich-91	97	5	serum	serum	NOUN
biomedich-91	97	6	and	and	CCONJ
biomedich-91	97	7	liver	liver	NOUN
biomedich-91	97	8	levels	level	NOUN
biomedich-91	97	9	of	of	ADP
biomedich-91	97	10	alp	alp	PROPN
biomedich-91	97	11	,	,	PUNCT
biomedich-91	97	12	ast	ast	PROPN
biomedich-91	97	13	,	,	PUNCT
biomedich-91	97	14	alt	alt	ADJ
biomedich-91	97	15	,	,	PUNCT
biomedich-91	97	16	ggt	ggt	NOUN
biomedich-91	97	17	,	,	PUNCT
biomedich-91	97	18	and	and	CCONJ
biomedich-91	97	19	ldh	ldh	VERB
biomedich-91	97	20	in	in	ADP
biomedich-91	97	21	rats	rat	NOUN
biomedich-91	97	22	treated	treat	VERB
biomedich-91	97	23	with	with	ADP
biomedich-91	97	24	tramadol	tramadol	NOUN
biomedich-91	97	25	-	-	PUNCT
biomedich-91	97	26	diclofenac	diclofenac	NOUN
biomedich-91	97	27	which	which	PRON
biomedich-91	97	28	is	be	AUX
biomedich-91	97	29	a	a	DET
biomedich-91	97	30	sign	sign	NOUN
biomedich-91	97	31	of	of	ADP
biomedich-91	97	32	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	97	33	.	.	PUNCT
biomedich-91	98	1	bilirubin	bilirubin	NOUN
biomedich-91	98	2	is	be	AUX
biomedich-91	98	3	an	an	DET
biomedich-91	98	4	endogenous	endogenous	ADJ
biomedich-91	98	5	anion	anion	NOUN
biomedich-91	98	6	derived	derive	VERB
biomedich-91	98	7	from	from	ADP
biomedich-91	98	8	the	the	DET
biomedich-91	98	9	regular	regular	ADJ
biomedich-91	98	10	degradation	degradation	NOUN
biomedich-91	98	11	of	of	ADP
biomedich-91	98	12	haemoglobin	haemoglobin	NOUN
biomedich-91	98	13	from	from	ADP
biomedich-91	98	14	the	the	DET
biomedich-91	98	15	red	red	ADJ
biomedich-91	98	16	blood	blood	NOUN
biomedich-91	98	17	cells	cell	NOUN
biomedich-91	98	18	and	and	CCONJ
biomedich-91	98	19	excreted	excrete	VERB
biomedich-91	98	20	from	from	ADP
biomedich-91	98	21	the	the	DET
biomedich-91	98	22	liver	liver	NOUN
biomedich-91	98	23	in	in	ADP
biomedich-91	98	24	the	the	DET
biomedich-91	98	25	bile	bile	NOUN
biomedich-91	98	26	(	(	PUNCT
biomedich-91	98	27	saukkonen	saukkonen	NOUN
biomedich-91	98	28	et	et	PROPN
biomedich-91	98	29	al	al	PROPN
biomedich-91	98	30	.	.	PROPN
biomedich-91	98	31	,	,	PUNCT
biomedich-91	98	32	2006	2006	NUM
biomedich-91	98	33	)	)	PUNCT
biomedich-91	98	34	.	.	PUNCT
biomedich-91	99	1	toxic	toxic	ADJ
biomedich-91	99	2	insult	insult	NOUN
biomedich-91	99	3	to	to	ADP
biomedich-91	99	4	the	the	DET
biomedich-91	99	5	liver	liver	NOUN
biomedich-91	99	6	can	can	AUX
biomedich-91	99	7	impair	impair	VERB
biomedich-91	99	8	its	its	PRON
biomedich-91	99	9	excretory	excretory	NOUN
biomedich-91	99	10	capacity	capacity	NOUN
biomedich-91	99	11	to	to	PART
biomedich-91	99	12	dispose	dispose	VERB
biomedich-91	99	13	bilirubin	bilirubin	NOUN
biomedich-91	99	14	stimulating	stimulate	VERB
biomedich-91	99	15	serum	serum	NOUN
biomedich-91	99	16	accumulation	accumulation	NOUN
biomedich-91	99	17	(	(	PUNCT
biomedich-91	99	18	gaw	gaw	PROPN
biomedich-91	99	19	et	et	NOUN
biomedich-91	99	20	al	al	PROPN
biomedich-91	99	21	.	.	PROPN
biomedich-91	99	22	,	,	PUNCT
biomedich-91	99	23	1999	1999	NUM
biomedich-91	99	24	;	;	PUNCT
biomedich-91	99	25	jain	jain	PROPN
biomedich-91	99	26	et	et	PROPN
biomedich-91	99	27	al	al	PROPN
biomedich-91	99	28	.	.	PROPN
biomedich-91	99	29	,	,	PUNCT
biomedich-91	99	30	2008	2008	NUM
biomedich-91	99	31	)	)	PUNCT
biomedich-91	99	32	.	.	PUNCT
biomedich-91	100	1	this	this	DET
biomedich-91	100	2	study	study	NOUN
biomedich-91	100	3	observed	observe	VERB
biomedich-91	100	4	elevated	elevate	VERB
biomedich-91	100	5	serum	serum	NOUN
biomedich-91	100	6	cb	cb	PROPN
biomedich-91	100	7	and	and	CCONJ
biomedich-91	100	8	tb	tb	ADP
biomedich-91	100	9	levels	level	NOUN
biomedich-91	100	10	in	in	ADP
biomedich-91	100	11	rats	rat	NOUN
biomedich-91	100	12	treated	treat	VERB
biomedich-91	100	13	with	with	ADP
biomedich-91	100	14	tramadol	tramadol	NOUN
biomedich-91	100	15	-	-	PUNCT
biomedich-91	100	16	diclofenac	diclofenac	NOUN
biomedich-91	100	17	.	.	PUNCT
biomedich-91	101	1	the	the	DET
biomedich-91	101	2	anti	anti	ADJ
biomedich-91	101	3	-	-	ADJ
biomedich-91	101	4	oxidative	oxidative	ADJ
biomedich-91	101	5	defense	defense	NOUN
biomedich-91	101	6	system	system	NOUN
biomedich-91	101	7	which	which	PRON
biomedich-91	101	8	includes	include	VERB
biomedich-91	101	9	sod	sod	NOUN
biomedich-91	101	10	,	,	PUNCT
biomedich-91	101	11	cat	cat	NOUN
biomedich-91	101	12	,	,	PUNCT
biomedich-91	101	13	gsh	gsh	PROPN
biomedich-91	101	14	and	and	CCONJ
biomedich-91	101	15	gpx	gpx	NOUN
biomedich-91	101	16	is	be	AUX
biomedich-91	101	17	necessary	necessary	ADJ
biomedich-91	101	18	for	for	ADP
biomedich-91	101	19	the	the	DET
biomedich-91	101	20	maintenance	maintenance	NOUN
biomedich-91	101	21	of	of	ADP
biomedich-91	101	22	redox	redox	ADJ
biomedich-91	101	23	homeostasis	homeostasis	NOUN
biomedich-91	101	24	in	in	ADP
biomedich-91	101	25	organisms	organism	NOUN
biomedich-91	101	26	.	.	PUNCT
biomedich-91	102	1	it	it	PRON
biomedich-91	102	2	terminates	terminate	VERB
biomedich-91	102	3	or	or	CCONJ
biomedich-91	102	4	prevents	prevent	VERB
biomedich-91	102	5	free	free	ADJ
biomedich-91	102	6	radicals	radical	NOUN
biomedich-91	102	7	such	such	ADJ
biomedich-91	102	8	as	as	ADP
biomedich-91	102	9	reactive	reactive	ADJ
biomedich-91	102	10	oxygen	oxygen	NOUN
biomedich-91	102	11	species	specie	NOUN
biomedich-91	102	12	(	(	PUNCT
biomedich-91	102	13	ros	ros	PROPN
biomedich-91	102	14	)	)	PUNCT
biomedich-91	102	15	from	from	ADP
biomedich-91	102	16	incapacitating	incapacitate	VERB
biomedich-91	102	17	the	the	DET
biomedich-91	102	18	functions	function	NOUN
biomedich-91	102	19	of	of	ADP
biomedich-91	102	20	biomolecules	biomolecule	NOUN
biomedich-91	102	21	through	through	ADP
biomedich-91	102	22	oxidative	oxidative	ADJ
biomedich-91	102	23	stress	stress	NOUN
biomedich-91	102	24	(	(	PUNCT
biomedich-91	102	25	os	os	NOUN
biomedich-91	102	26	)	)	PUNCT
biomedich-91	102	27	(	(	PUNCT
biomedich-91	102	28	borković	borković	NOUN
biomedich-91	102	29	et	et	PROPN
biomedich-91	102	30	al	al	PROPN
biomedich-91	102	31	.	.	PROPN
biomedich-91	102	32	,	,	PUNCT
biomedich-91	102	33	2005	2005	NUM
biomedich-91	102	34	)	)	PUNCT
biomedich-91	102	35	.	.	PUNCT
biomedich-91	103	1	however	however	ADV
biomedich-91	103	2	,	,	PUNCT
biomedich-91	103	3	the	the	DET
biomedich-91	103	4	functions	function	NOUN
biomedich-91	103	5	of	of	ADP
biomedich-91	103	6	anti	anti	ADJ
biomedich-91	103	7	-	-	ADJ
biomedich-91	103	8	oxidative	oxidative	ADJ
biomedich-91	103	9	system	system	NOUN
biomedich-91	103	10	can	can	AUX
biomedich-91	103	11	be	be	AUX
biomedich-91	103	12	surmounted	surmount	VERB
biomedich-91	103	13	or	or	CCONJ
biomedich-91	103	14	incapacitated	incapacitate	VERB
biomedich-91	103	15	via	via	ADP
biomedich-91	103	16	depletion	depletion	NOUN
biomedich-91	103	17	by	by	ADP
biomedich-91	103	18	over	over	ADP
biomedich-91	103	19	whelming	whelm	VERB
biomedich-91	103	20	actions	action	NOUN
biomedich-91	103	21	of	of	ADP
biomedich-91	103	22	free	free	ADJ
biomedich-91	103	23	radicals	radical	NOUN
biomedich-91	103	24	.	.	PUNCT
biomedich-91	104	1	this	this	DET
biomedich-91	104	2	study	study	NOUN
biomedich-91	104	3	observed	observe	VERB
biomedich-91	104	4	hepatic	hepatic	ADJ
biomedich-91	104	5	depletions	depletion	NOUN
biomedich-91	104	6	of	of	ADP
biomedich-91	104	7	sod	sod	NOUN
biomedich-91	104	8	,	,	PUNCT
biomedich-91	104	9	cat	cat	NOUN
biomedich-91	104	10	,	,	PUNCT
biomedich-91	104	11	gsh	gsh	PROPN
biomedich-91	104	12	and	and	CCONJ
biomedich-91	104	13	gpx	gpx	PROPN
biomedich-91	104	14	in	in	ADP
biomedich-91	104	15	rats	rat	NOUN
biomedich-91	104	16	treated	treat	VERB
biomedich-91	104	17	with	with	ADP
biomedich-91	104	18	tramadol	tramadol	NOUN
biomedich-91	104	19	-	-	PUNCT
biomedich-91	104	20	diclofenac	diclofenac	NOUN
biomedich-91	104	21	.	.	PUNCT
biomedich-91	105	1	this	this	PRON
biomedich-91	105	2	is	be	AUX
biomedich-91	105	3	an	an	DET
biomedich-91	105	4	evidence	evidence	NOUN
biomedich-91	105	5	which	which	PRON
biomedich-91	105	6	shows	show	VERB
biomedich-91	105	7	that	that	SCONJ
biomedich-91	105	8	os	os	NOUN
biomedich-91	105	9	is	be	AUX
biomedich-91	105	10	a	a	DET
biomedich-91	105	11	factor	factor	NOUN
biomedich-91	105	12	in	in	ADP
biomedich-91	105	13	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	105	14	induced	induce	VERB
biomedich-91	105	15	by	by	ADP
biomedich-91	105	16	tramadol	tramadol	NOUN
biomedich-91	105	17	-	-	PUNCT
biomedich-91	105	18	diclofenac	diclofenac	NOUN
biomedich-91	105	19	.	.	PUNCT
biomedich-91	106	1	lipid	lipid	NOUN
biomedich-91	106	2	peroxidation	peroxidation	NOUN
biomedich-91	106	3	(	(	PUNCT
biomedich-91	106	4	lpo	lpo	PROPN
biomedich-91	106	5	)	)	PUNCT
biomedich-91	106	6	is	be	AUX
biomedich-91	106	7	an	an	DET
biomedich-91	106	8	oxidative	oxidative	ADJ
biomedich-91	106	9	degradation	degradation	NOUN
biomedich-91	106	10	of	of	ADP
biomedich-91	106	11	polyunsaturated	polyunsaturated	ADJ
biomedich-91	106	12	fatty	fatty	NOUN
biomedich-91	106	13	acids	acid	NOUN
biomedich-91	106	14	which	which	PRON
biomedich-91	106	15	can	can	AUX
biomedich-91	106	16	cause	cause	VERB
biomedich-91	106	17	impairment	impairment	NOUN
biomedich-91	106	18	in	in	ADP
biomedich-91	106	19	membrane	membrane	NOUN
biomedich-91	106	20	structure	structure	NOUN
biomedich-91	106	21	and	and	CCONJ
biomedich-91	106	22	function	function	NOUN
biomedich-91	106	23	.	.	PUNCT
biomedich-91	107	1	mda	mda	PROPN
biomedich-91	107	2	level	level	NOUN
biomedich-91	107	3	which	which	PRON
biomedich-91	107	4	is	be	AUX
biomedich-91	107	5	an	an	DET
biomedich-91	107	6	important	important	ADJ
biomedich-91	107	7	indicator	indicator	NOUN
biomedich-91	107	8	of	of	ADP
biomedich-91	107	9	lpo	lpo	PROPN
biomedich-91	107	10	can	can	AUX
biomedich-91	107	11	indirectly	indirectly	ADV
biomedich-91	107	12	reflect	reflect	VERB
biomedich-91	107	13	the	the	DET
biomedich-91	107	14	extent	extent	NOUN
biomedich-91	107	15	of	of	ADP
biomedich-91	107	16	hepatic	hepatic	ADJ
biomedich-91	107	17	lpo	lpo	PROPN
biomedich-91	107	18	in	in	ADP
biomedich-91	107	19	-	-	PUNCT
biomedich-91	107	20	vivo	vivo	NOUN
biomedich-91	107	21	and	and	CCONJ
biomedich-91	107	22	in	in	ADP
biomedich-91	107	23	-	-	PUNCT
biomedich-91	107	24	vitro	vitro	X
biomedich-91	107	25	(	(	PUNCT
biomedich-91	107	26	jafari	jafari	PROPN
biomedich-91	107	27	et	et	PROPN
biomedich-91	107	28	al	al	PROPN
biomedich-91	107	29	.	.	PROPN
biomedich-91	107	30	,	,	PUNCT
biomedich-91	107	31	2012	2012	NUM
biomedich-91	107	32	)	)	PUNCT
biomedich-91	107	33	.	.	PUNCT
biomedich-91	108	1	in	in	ADP
biomedich-91	108	2	this	this	DET
biomedich-91	108	3	study	study	NOUN
biomedich-91	108	4	,	,	PUNCT
biomedich-91	108	5	hepatic	hepatic	ADJ
biomedich-91	108	6	mda	mda	PROPN
biomedich-91	108	7	levels	level	NOUN
biomedich-91	108	8	were	be	AUX
biomedich-91	108	9	increased	increase	VERB
biomedich-91	108	10	in	in	ADP
biomedich-91	108	11	rats	rat	NOUN
biomedich-91	108	12	treated	treat	VERB
biomedich-91	108	13	with	with	ADP
biomedich-91	108	14	tramadol	tramadol	NOUN
biomedich-91	108	15	-	-	PUNCT
biomedich-91	108	16	diclofenac	diclofenac	NOUN
biomedich-91	108	17	.	.	PUNCT
biomedich-91	109	1	this	this	DET
biomedich-91	109	2	observation	observation	NOUN
biomedich-91	109	3	attests	attest	VERB
biomedich-91	109	4	to	to	ADP
biomedich-91	109	5	the	the	DET
biomedich-91	109	6	involvement	involvement	NOUN
biomedich-91	109	7	of	of	ADP
biomedich-91	109	8	lpo	lpo	PROPN
biomedich-91	109	9	in	in	ADP
biomedich-91	109	10	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	109	11	induced	induce	VERB
biomedich-91	109	12	by	by	ADP
biomedich-91	109	13	tramadol	tramadol	NOUN
biomedich-91	109	14	-	-	PUNCT
biomedich-91	109	15	diclofenac	diclofenac	NOUN
biomedich-91	109	16	.	.	PUNCT
biomedich-91	110	1	furthermore	furthermore	ADV
biomedich-91	110	2	,	,	PUNCT
biomedich-91	110	3	the	the	DET
biomedich-91	110	4	current	current	ADJ
biomedich-91	110	5	study	study	NOUN
biomedich-91	110	6	observed	observe	VERB
biomedich-91	110	7	hepatocyte	hepatocyte	NOUN
biomedich-91	110	8	necrosis	necrosis	NOUN
biomedich-91	110	9	in	in	ADP
biomedich-91	110	10	rats	rat	NOUN
biomedich-91	110	11	treated	treat	VERB
biomedich-91	110	12	with	with	ADP
biomedich-91	110	13	tramadol	tramadol	NOUN
biomedich-91	110	14	-	-	PUNCT
biomedich-91	110	15	diclofenac	diclofenac	NOUN
biomedich-91	110	16	which	which	PRON
biomedich-91	110	17	correlates	correlate	VERB
biomedich-91	110	18	with	with	ADP
biomedich-91	110	19	changes	change	NOUN
biomedich-91	110	20	observed	observe	VERB
biomedich-91	110	21	in	in	ADP
biomedich-91	110	22	evaluated	evaluated	ADJ
biomedich-91	110	23	biochemical	biochemical	ADJ
biomedich-91	110	24	parameters	parameter	NOUN
biomedich-91	110	25	.	.	PUNCT
biomedich-91	111	1	this	this	DET
biomedich-91	111	2	study	study	NOUN
biomedich-91	111	3	was	be	AUX
biomedich-91	111	4	able	able	ADJ
biomedich-91	111	5	to	to	PART
biomedich-91	111	6	show	show	VERB
biomedich-91	111	7	that	that	SCONJ
biomedich-91	111	8	tramadol	tramadol	NOUN
biomedich-91	111	9	-	-	PUNCT
biomedich-91	111	10	diclofenac	diclofenac	NOUN
biomedich-91	111	11	use	use	NOUN
biomedich-91	111	12	may	may	AUX
biomedich-91	111	13	increase	increase	VERB
biomedich-91	111	14	the	the	DET
biomedich-91	111	15	risk	risk	NOUN
biomedich-91	111	16	of	of	ADP
biomedich-91	111	17	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	111	18	.	.	PUNCT
biomedich-91	112	1	the	the	DET
biomedich-91	112	2	use	use	NOUN
biomedich-91	112	3	of	of	ADP
biomedich-91	112	4	diclofenac	diclofenac	NOUN
biomedich-91	112	5	has	have	AUX
biomedich-91	112	6	been	be	AUX
biomedich-91	112	7	associated	associate	VERB
biomedich-91	112	8	with	with	ADP
biomedich-91	112	9	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	112	10	(	(	PUNCT
biomedich-91	112	11	hussein	hussein	PROPN
biomedich-91	112	12	et	et	PROPN
biomedich-91	112	13	al	al	PROPN
biomedich-91	112	14	.	.	PROPN
biomedich-91	112	15	,	,	PUNCT
biomedich-91	112	16	2016	2016	NUM
biomedich-91	112	17	)	)	PUNCT
biomedich-91	112	18	and	and	CCONJ
biomedich-91	112	19	hepatic	hepatic	ADJ
biomedich-91	112	20	os	os	NOUN
biomedich-91	112	21	(	(	PUNCT
biomedich-91	112	22	das	das	PROPN
biomedich-91	112	23	and	and	CCONJ
biomedich-91	112	24	roy	roy	PROPN
biomedich-91	112	25	,	,	PUNCT
biomedich-91	112	26	2012	2012	NUM
biomedich-91	112	27	)	)	PUNCT
biomedich-91	112	28	which	which	PRON
biomedich-91	112	29	is	be	AUX
biomedich-91	112	30	consistent	consistent	ADJ
biomedich-91	112	31	with	with	ADP
biomedich-91	112	32	findings	finding	NOUN
biomedich-91	112	33	in	in	ADP
biomedich-91	112	34	this	this	DET
biomedich-91	112	35	study	study	NOUN
biomedich-91	112	36	.	.	PUNCT
biomedich-91	113	1	the	the	DET
biomedich-91	113	2	exact	exact	ADJ
biomedich-91	113	3	mechanism	mechanism	NOUN
biomedich-91	113	4	by	by	ADP
biomedich-91	113	5	which	which	PRON
biomedich-91	113	6	diclofenac	diclofenac	NOUN
biomedich-91	113	7	causes	cause	VERB
biomedich-91	113	8	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	113	9	is	be	AUX
biomedich-91	113	10	not	not	PART
biomedich-91	113	11	well	well	ADV
biomedich-91	113	12	understood	understand	VERB
biomedich-91	113	13	,	,	PUNCT
biomedich-91	113	14	but	but	CCONJ
biomedich-91	113	15	diclofenac	diclofenac	NOUN
biomedich-91	113	16	is	be	AUX
biomedich-91	113	17	metabolized	metabolize	VERB
biomedich-91	113	18	in	in	ADP
biomedich-91	113	19	the	the	DET
biomedich-91	113	20	liver	liver	NOUN
biomedich-91	113	21	(	(	PUNCT
biomedich-91	113	22	castel	castel	PROPN
biomedich-91	113	23	et	et	PROPN
biomedich-91	113	24	al	al	PROPN
biomedich-91	113	25	.	.	PROPN
biomedich-91	113	26	,	,	PUNCT
biomedich-91	113	27	1997	1997	NUM
biomedich-91	113	28	)	)	PUNCT
biomedich-91	113	29	and	and	CCONJ
biomedich-91	113	30	its	its	PRON
biomedich-91	113	31	hepatotoxic	hepatotoxic	ADJ
biomedich-91	113	32	effect	effect	NOUN
biomedich-91	113	33	has	have	AUX
biomedich-91	113	34	been	be	AUX
biomedich-91	113	35	related	relate	VERB
biomedich-91	113	36	to	to	ADP
biomedich-91	113	37	its	its	PRON
biomedich-91	113	38	metabolites	metabolite	NOUN
biomedich-91	113	39	(	(	PUNCT
biomedich-91	113	40	4hydroxy	4hydroxy	PROPN
biomedich-91	113	41	3	3	NUM
biomedich-91	113	42	diclofenac	diclofenac	NOUN
biomedich-91	113	43	,	,	PUNCT
biomedich-91	113	44	5	5	NUM
biomedich-91	113	45	hydroxy	hydroxy	NOUN
biomedich-91	113	46	4	4	NUM
biomedich-91	113	47	diclofenac	diclofenac	NOUN
biomedich-91	113	48	and	and	CCONJ
biomedich-91	113	49	5	5	NUM
biomedich-91	113	50	hydroxy	hydroxy	NOUN
biomedich-91	113	51	6	6	NUM
biomedich-91	113	52	diclofenac	diclofenac	NOUN
biomedich-91	113	53	)	)	PUNCT
biomedich-91	113	54	(	(	PUNCT
biomedich-91	113	55	tang	tang	NOUN
biomedich-91	113	56	et	et	PROPN
biomedich-91	113	57	al	al	PROPN
biomedich-91	113	58	.	.	PROPN
biomedich-91	113	59	,	,	PUNCT
biomedich-91	113	60	1999	1999	NUM
biomedich-91	113	61	)	)	PUNCT
biomedich-91	113	62	.	.	PUNCT
biomedich-91	114	1	also	also	ADV
biomedich-91	114	2	,	,	PUNCT
biomedich-91	114	3	studies	study	NOUN
biomedich-91	114	4	have	have	AUX
biomedich-91	114	5	associated	associate	VERB
biomedich-91	114	6	tramadol	tramadol	NOUN
biomedich-91	114	7	with	with	ADP
biomedich-91	114	8	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	114	9	(	(	PUNCT
biomedich-91	114	10	el	el	NOUN
biomedich-91	114	11	-	-	NOUN
biomedich-91	114	12	wessemy	wessemy	NOUN
biomedich-91	114	13	,	,	PUNCT
biomedich-91	114	14	2008	2008	NUM
biomedich-91	114	15	)	)	PUNCT
biomedich-91	114	16	characterized	characterize	VERB
biomedich-91	114	17	by	by	ADP
biomedich-91	114	18	os	os	PROPN
biomedich-91	114	19	(	(	PUNCT
biomedich-91	114	20	rukhshanda	rukhshanda	PROPN
biomedich-91	114	21	et	et	PROPN
biomedich-91	114	22	al	al	PROPN
biomedich-91	114	23	.	.	PROPN
biomedich-91	114	24	,	,	PUNCT
biomedich-91	114	25	2014	2014	NUM
biomedich-91	114	26	)	)	PUNCT
biomedich-91	114	27	which	which	PRON
biomedich-91	114	28	is	be	AUX
biomedich-91	114	29	in	in	ADP
biomedich-91	114	30	agreement	agreement	NOUN
biomedich-91	114	31	with	with	ADP
biomedich-91	114	32	observation	observation	NOUN
biomedich-91	114	33	in	in	ADP
biomedich-91	114	34	the	the	DET
biomedich-91	114	35	present	present	ADJ
biomedich-91	114	36	study	study	NOUN
biomedich-91	114	37	.	.	PUNCT
biomedich-91	115	1	the	the	DET
biomedich-91	115	2	mechanism	mechanism	NOUN
biomedich-91	115	3	by	by	ADP
biomedich-91	115	4	which	which	PRON
biomedich-91	115	5	tramadol	tramadol	NOUN
biomedich-91	115	6	causes	cause	VERB
biomedich-91	115	7	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	115	8	is	be	AUX
biomedich-91	115	9	not	not	PART
biomedich-91	115	10	fully	fully	ADV
biomedich-91	115	11	known	know	VERB
biomedich-91	115	12	,	,	PUNCT
biomedich-91	115	13	but	but	CCONJ
biomedich-91	115	14	studies	study	NOUN
biomedich-91	115	15	have	have	AUX
biomedich-91	115	16	speculated	speculate	VERB
biomedich-91	115	17	that	that	SCONJ
biomedich-91	115	18	tramadol	tramadol	NOUN
biomedich-91	115	19	and/or	and/or	CCONJ
biomedich-91	115	20	its	its	PRON
biomedich-91	115	21	active	active	ADJ
biomedich-91	115	22	metabolite	metabolite	NOUN
biomedich-91	115	23	can	can	AUX
biomedich-91	115	24	stimulate	stimulate	VERB
biomedich-91	115	25	hepatic	hepatic	ADJ
biomedich-91	115	26	ros	ros	PROPN
biomedich-91	115	27	production	production	NOUN
biomedich-91	115	28	leading	lead	VERB
biomedich-91	115	29	to	to	ADP
biomedich-91	115	30	os	os	NOUN
biomedich-91	115	31	and	and	CCONJ
biomedich-91	115	32	hepatic	hepatic	ADJ
biomedich-91	115	33	biomolecular	biomolecular	ADJ
biomedich-91	115	34	damage	damage	NOUN
biomedich-91	115	35	(	(	PUNCT
biomedich-91	115	36	singal	singal	PROPN
biomedich-91	115	37	et	et	PROPN
biomedich-91	115	38	al	al	PROPN
biomedich-91	115	39	.	.	PROPN
biomedich-91	115	40	,	,	PUNCT
biomedich-91	115	41	1998	1998	NUM
biomedich-91	115	42	)	)	PUNCT
biomedich-91	115	43	.	.	PUNCT
biomedich-91	116	1	conclusion	conclusion	NOUN
biomedich-91	116	2	tramadol	tramadol	NOUN
biomedich-91	116	3	-	-	PUNCT
biomedich-91	116	4	diclofenac	diclofenac	ADJ
biomedich-91	116	5	use	use	NOUN
biomedich-91	116	6	may	may	AUX
biomedich-91	116	7	be	be	AUX
biomedich-91	116	8	associated	associate	VERB
biomedich-91	116	9	with	with	ADP
biomedich-91	116	10	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	116	11	at	at	ADP
biomedich-91	116	12	the	the	DET
biomedich-91	116	13	doses	dose	NOUN
biomedich-91	116	14	use	use	VERB
biomedich-91	116	15	for	for	ADP
biomedich-91	116	16	this	this	DET
biomedich-91	116	17	study	study	NOUN
biomedich-91	116	18	.	.	PUNCT
biomedich-91	117	1	conflict	conflict	NOUN
biomedich-91	117	2	of	of	ADP
biomedich-91	117	3	interest	interest	NOUN
biomedich-91	117	4	:	:	PUNCT
biomedich-91	117	5	none	none	NOUN
biomedich-91	117	6	references	reference	NOUN
biomedich-91	117	7	aebi	aebi	VERB
biomedich-91	117	8	h.	h.	PROPN
biomedich-91	117	9	catalase	catalase	PROPN
biomedich-91	117	10	in	in	ADP
biomedich-91	117	11	vitro	vitro	NOUN
biomedich-91	117	12	,	,	PUNCT
biomedich-91	117	13	in	in	ADP
biomedich-91	117	14	method	method	NOUN
biomedich-91	117	15	in	in	ADP
biomedich-91	117	16	enzymology	enzymology	NOUN
biomedich-91	117	17	,	,	PUNCT
biomedich-91	117	18	s.	s.	PROPN
biomedich-91	117	19	p.	p.	PROPN
biomedich-91	117	20	colowick	colowick	PROPN
biomedich-91	117	21	and	and	CCONJ
biomedich-91	117	22	n.	n.	PROPN
biomedich-91	117	23	o.	o.	PROPN
biomedich-91	117	24	kaplane	kaplane	PROPN
biomedich-91	117	25	,	,	PUNCT
biomedich-91	117	26	eds	eds	PROPN
biomedich-91	117	27	.	.	PROPN
biomedich-91	117	28	,	,	PUNCT
biomedich-91	117	29	1984	1984	NUM
biomedich-91	117	30	;	;	PUNCT
biomedich-91	117	31	academic	academic	ADJ
biomedich-91	117	32	press	press	NOUN
biomedich-91	117	33	,	,	PUNCT
biomedich-91	117	34	new	new	PROPN
biomedich-91	117	35	york	york	PROPN
biomedich-91	117	36	,	,	PUNCT
biomedich-91	117	37	ny	ny	PROPN
biomedich-91	117	38	,	,	PUNCT
biomedich-91	117	39	usa	usa	PROPN
biomedich-91	117	40	.	.	PROPN
biomedich-91	117	41	bailey	bailey	PROPN
biomedich-91	117	42	as	as	ADP
biomedich-91	117	43	,	,	PUNCT
biomedich-91	117	44	zidell	zidell	PROPN
biomedich-91	117	45	rh	rh	PROPN
biomedich-91	117	46	,	,	PUNCT
biomedich-91	117	47	and	and	CCONJ
biomedich-91	117	48	perry	perry	PROPN
biomedich-91	117	49	rw	rw	PROPN
biomedich-91	117	50	.	.	PUNCT
biomedich-91	118	1	(	(	PUNCT
biomedich-91	118	2	2004	2004	NUM
biomedich-91	118	3	)	)	PUNCT
biomedich-91	118	4	.	.	PUNCT
biomedich-91	119	1	relationships	relationship	NOUN
biomedich-91	119	2	between	between	ADP
biomedich-91	119	3	organ	organ	NOUN
biomedich-91	119	4	weight	weight	NOUN
biomedich-91	119	5	and	and	CCONJ
biomedich-91	119	6	body	body	NOUN
biomedich-91	119	7	/	/	SYM
biomedich-91	119	8	brainweight	brainweight	NOUN
biomedich-91	119	9	in	in	ADP
biomedich-91	119	10	the	the	DET
biomedich-91	119	11	rat	rat	NOUN
biomedich-91	119	12	:	:	PUNCT
biomedich-91	119	13	what	what	PRON
biomedich-91	119	14	is	be	AUX
biomedich-91	119	15	the	the	DET
biomedich-91	119	16	best	good	ADJ
biomedich-91	119	17	analytical	analytical	ADJ
biomedich-91	119	18	endpoint	endpoint	NOUN
biomedich-91	119	19	?	?	PUNCT
biomedich-91	120	1	toxicologic	toxicologic	ADJ
biomedich-91	120	2	pathology	pathology	NOUN
biomedich-91	120	3	,	,	PUNCT
biomedich-91	120	4	32:448–466	32:448–466	NUM
biomedich-91	120	5	,	,	PUNCT
biomedich-91	120	6	blondel	blondel	PROPN
biomedich-91	120	7	rd	rd	PROPN
biomedich-91	120	8	l	l	PROPN
biomedich-91	120	9	,	,	PUNCT
biomedich-91	120	10	(	(	PUNCT
biomedich-91	120	11	2013	2013	NUM
biomedich-91	120	12	)	)	PUNCT
biomedich-91	120	13	.	.	PUNCT
biomedich-91	121	1	azadfard	azadfard	PROPN
biomedich-91	121	2	m	m	PROPN
biomedich-91	121	3	,	,	PUNCT
biomedich-91	121	4	wisniewski	wisniewski	PROPN
biomedich-91	121	5	am	am	PROPN
biomedich-91	121	6	.	.	PUNCT
biomedich-91	122	1	pharmacologic	pharmacologic	ADJ
biomedich-91	122	2	therapy	therapy	NOUN
biomedich-91	122	3	for	for	ADP
biomedich-91	122	4	acute	acute	ADJ
biomedich-91	122	5	pain	pain	NOUN
biomedich-91	122	6	am	be	AUX
biomedich-91	122	7	fam	fam	NOUN
biomedich-91	122	8	physician	physician	NOUN
biomedich-91	122	9	,	,	PUNCT
biomedich-91	122	10	87	87	NUM
biomedich-91	122	11	:	:	PUNCT
biomedich-91	122	12	766	766	NUM
biomedich-91	122	13	-	-	SYM
biomedich-91	122	14	772	772	NUM
biomedich-91	122	15	.	.	PUNCT
biomedich-91	123	1	borković	borković	PROPN
biomedich-91	123	2	s	s	PROPN
biomedich-91	123	3	s	s	PROPN
biomedich-91	123	4	,	,	PUNCT
biomedich-91	123	5	šaponjić	šaponjić	PROPN
biomedich-91	123	6	js	js	PROPN
biomedich-91	123	7	,	,	PUNCT
biomedich-91	123	8	pavlović	pavlović	NOUN
biomedich-91	123	9	s	s	PROPN
biomedich-91	123	10	z	z	PROPN
biomedich-91	123	11	,	,	PUNCT
biomedich-91	123	12	blagojević	blagojević	PROPN
biomedich-91	123	13	dp	dp	PROPN
biomedich-91	123	14	,	,	PUNCT
biomedich-91	123	15	milošević	milošević	PROPN
biomedich-91	123	16	s	s	PROPN
biomedich-91	123	17	m	m	PROPN
biomedich-91	123	18	,	,	PUNCT
biomedich-91	123	19	kovačević	kovačević	NOUN
biomedich-91	123	20	tb	tb	NOUN
biomedich-91	123	21	et	et	PROPN
biomedich-91	123	22	al	al	PROPN
biomedich-91	123	23	.	.	PUNCT
biomedich-91	124	1	(	(	PUNCT
biomedich-91	124	2	2005	2005	NUM
biomedich-91	124	3	)	)	PUNCT
biomedich-91	124	4	.	.	PUNCT
biomedich-91	125	1	the	the	DET
biomedich-91	125	2	activity	activity	NOUN
biomedich-91	125	3	of	of	ADP
biomedich-91	125	4	antioxidant	antioxidant	ADJ
biomedich-91	125	5	defence	defence	NOUN
biomedich-91	125	6	enzymes	enzyme	NOUN
biomedich-91	125	7	in	in	ADP
biomedich-91	125	8	the	the	DET
biomedich-91	125	9	mussel	mussel	NOUN
biomedich-91	125	10	mytilusgalloprovincialis	mytilusgalloprovinciali	NOUN
biomedich-91	125	11	from	from	ADP
biomedich-91	125	12	the	the	DET
biomedich-91	125	13	adriatic	adriatic	PROPN
biomedich-91	125	14	sea	sea	PROPN
biomedich-91	125	15	.	.	PUNCT
biomedich-91	125	16	comp	comp	PROPN
biomedich-91	125	17	.	.	PUNCT
biomedich-91	126	1	bioch	bioch	PROPN
biomedich-91	126	2	physiol	physiol	PROPN
biomedich-91	126	3	,	,	PUNCT
biomedich-91	126	4	141	141	NUM
biomedich-91	126	5	:	:	SYM
biomedich-91	126	6	366	366	NUM
biomedich-91	126	7	–	–	PUNCT
biomedich-91	126	8	374	374	NUM
biomedich-91	126	9	.	.	PUNCT
biomedich-91	127	1	buege	buege	PROPN
biomedich-91	127	2	j	j	PROPN
biomedich-91	127	3	a	a	PROPN
biomedich-91	127	4	and	and	CCONJ
biomedich-91	127	5	aust	aust	PROPN
biomedich-91	127	6	s	s	PROPN
biomedich-91	127	7	d.	d.	PROPN
biomedich-91	127	8	(	(	PUNCT
biomedich-91	127	9	1978	1978	NUM
biomedich-91	127	10	)	)	PUNCT
biomedich-91	127	11	.	.	PUNCT
biomedich-91	128	1	microsomal	microsomal	ADJ
biomedich-91	128	2	lipid	lipid	NOUN
biomedich-91	128	3	peroxidation	peroxidation	NOUN
biomedich-91	128	4	.	.	PUNCT
biomedich-91	129	1	methods	method	NOUN
biomedich-91	129	2	enzymol.52	enzymol.52	ADJ
biomedich-91	129	3	:	:	PUNCT
biomedich-91	129	4	302	302	NUM
biomedich-91	129	5	-	-	SYM
biomedich-91	129	6	310	310	NUM
biomedich-91	129	7	castel	castel	NOUN
biomedich-91	129	8	jv	jv	PROPN
biomedich-91	129	9	,	,	PUNCT
biomedich-91	129	10	gomez	gomez	NOUN
biomedich-91	129	11	-	-	PUNCT
biomedich-91	129	12	lechon	lechon	NOUN
biomedich-91	129	13	,	,	PUNCT
biomedich-91	129	14	m	m	PROPN
biomedich-91	129	15	j	j	PROPN
biomedich-91	129	16	,	,	PUNCT
biomedich-91	129	17	ponsoda	ponsoda	NOUN
biomedich-91	129	18	x	x	NOUN
biomedich-91	129	19	,	,	PUNCT
biomedich-91	129	20	bort	bort	PROPN
biomedich-91	129	21	r	r	PROPN
biomedich-91	129	22	(	(	PUNCT
biomedich-91	129	23	1997	1997	NUM
biomedich-91	129	24	)	)	PUNCT
biomedich-91	129	25	.	.	PUNCT
biomedich-91	130	1	the	the	DET
biomedich-91	130	2	use	use	NOUN
biomedich-91	130	3	of	of	ADP
biomedich-91	130	4	cultured	cultured	ADJ
biomedich-91	130	5	hepatocytes	hepatocyte	NOUN
biomedich-91	130	6	to	to	PART
biomedich-91	130	7	investigate	investigate	VERB
biomedich-91	130	8	the	the	DET
biomedich-91	130	9	mechanism	mechanism	NOUN
biomedich-91	130	10	of	of	ADP
biomedich-91	130	11	drug	drug	NOUN
biomedich-91	130	12	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	130	13	.	.	PUNCT
biomedich-91	131	1	cell	cell	NOUN
biomedich-91	131	2	biol	biol	PROPN
biomedich-91	131	3	.	.	PUNCT
biomedich-91	132	1	toxicol	toxicol	PROPN
biomedich-91	132	2	.	.	PUNCT
biomedich-91	132	3	,	,	PUNCT
biomedich-91	132	4	(	(	PUNCT
biomedich-91	132	5	review),13	review),13	PROPN
biomedich-91	132	6	:	:	PUNCT
biomedich-91	132	7	331338	331338	NUM
biomedich-91	132	8	connors	connor	NOUN
biomedich-91	132	9	af	af	PROPN
biomedich-91	132	10	jr	jr	PROPN
biomedich-91	132	11	,	,	PUNCT
biomedich-91	132	12	dawson	dawson	PROPN
biomedich-91	132	13	nv	nv	PROPN
biomedich-91	132	14	,	,	PUNCT
biomedich-91	132	15	desbiens	desbien	VERB
biomedich-91	132	16	na	na	X
biomedich-91	132	17	(	(	PUNCT
biomedich-91	132	18	1995	1995	NUM
biomedich-91	132	19	)	)	PUNCT
biomedich-91	132	20	.	.	PUNCT
biomedich-91	133	1	a	a	DET
biomedich-91	133	2	controlled	control	VERB
biomedich-91	133	3	trial	trial	NOUN
biomedich-91	133	4	to	to	PART
biomedich-91	133	5	improve	improve	VERB
biomedich-91	133	6	care	care	NOUN
biomedich-91	133	7	for	for	ADP
biomedich-91	133	8	seriously	seriously	ADV
biomedich-91	133	9	ill	ill	ADV
biomedich-91	133	10	hospitalized	hospitalize	VERB
biomedich-91	133	11	patients.the	patients.the	DET
biomedich-91	133	12	study	study	NOUN
biomedich-91	133	13	to	to	PART
biomedich-91	133	14	understand	understand	VERB
biomedich-91	133	15	prognoses	prognosis	NOUN
biomedich-91	133	16	and	and	CCONJ
biomedich-91	133	17	preferences	preference	NOUN
biomedich-91	133	18	for	for	ADP
biomedich-91	133	19	outcomes	outcome	NOUN
biomedich-91	133	20	and	and	CCONJ
biomedich-91	133	21	risks	risk	NOUN
biomedich-91	133	22	of	of	ADP
biomedich-91	133	23	treatments	treatment	NOUN
biomedich-91	133	24	(	(	PUNCT
biomedich-91	133	25	support).the	support).the	DET
biomedich-91	133	26	support	support	NOUN
biomedich-91	133	27	principal	principal	ADJ
biomedich-91	133	28	investigators	investigator	NOUN
biomedich-91	133	29	.	.	PUNCT
biomedich-91	134	1	jama	jama	PROPN
biomedich-91	134	2	.	.	PUNCT
biomedich-91	135	1	1995	1995	NUM
biomedich-91	135	2	;	;	PUNCT
biomedich-91	135	3	274	274	NUM
biomedich-91	135	4	:	:	SYM
biomedich-91	135	5	1591–1598	1591–1598	NUM
biomedich-91	135	6	dubinsky	dubinsky	PROPN
biomedich-91	135	7	rm	rm	PROPN
biomedich-91	135	8	,	,	PUNCT
biomedich-91	135	9	miyasakij	miyasakij	PROPN
biomedich-91	135	10	.	.	PUNCT
biomedich-91	136	1	(	(	PUNCT
biomedich-91	136	2	2010	2010	NUM
biomedich-91	136	3	)	)	PUNCT
biomedich-91	136	4	.	.	PUNCT
biomedich-91	137	1	assessment	assessment	NOUN
biomedich-91	137	2	:	:	PUNCT
biomedich-91	137	3	efficacy	efficacy	NOUN
biomedich-91	137	4	of	of	ADP
biomedich-91	137	5	transcutaneous	transcutaneous	ADJ
biomedich-91	137	6	electric	electric	ADJ
biomedich-91	137	7	nerve	nerve	NOUN
biomedich-91	137	8	stimulation	stimulation	NOUN
biomedich-91	137	9	in	in	ADP
biomedich-91	137	10	the	the	DET
biomedich-91	137	11	treatment	treatment	NOUN
biomedich-91	137	12	of	of	ADP
biomedich-91	137	13	pain	pain	NOUN
biomedich-91	137	14	in	in	ADP
biomedich-91	137	15	neurologic	neurologic	ADJ
biomedich-91	137	16	disorders	disorder	NOUN
biomedich-91	137	17	(	(	PUNCT
biomedich-91	137	18	an	an	DET
biomedich-91	137	19	evidence	evidence	NOUN
biomedich-91	137	20	-	-	PUNCT
biomedich-91	137	21	based	base	VERB
biomedich-91	137	22	review	review	NOUN
biomedich-91	137	23	):	):	PUNCT
biomedich-91	137	24	adikwu	adikwu	PROPN
biomedich-91	137	25	&	&	CCONJ
biomedich-91	137	26	nelson	nelson	PROPN
biomedich-91	137	27	–	–	PUNCT
biomedich-91	137	28	hepatotoxic	hepatotoxic	ADJ
biomedich-91	137	29	effect	effect	NOUN
biomedich-91	137	30	of	of	ADP
biomedich-91	137	31	tramadol	tramadol	NOUN
biomedich-91	137	32	-	-	PUNCT
biomedich-91	137	33	diclofenac	diclofenac	NOUN
biomedich-91	137	34	45	45	NUM
biomedich-91	137	35	report	report	NOUN
biomedich-91	137	36	of	of	ADP
biomedich-91	137	37	the	the	DET
biomedich-91	137	38	therapeutics	therapeutic	NOUN
biomedich-91	137	39	and	and	CCONJ
biomedich-91	137	40	technology	technology	NOUN
biomedich-91	137	41	assessment	assessment	NOUN
biomedich-91	137	42	subcommittee	subcommittee	NOUN
biomedich-91	137	43	of	of	ADP
biomedich-91	137	44	the	the	DET
biomedich-91	137	45	american	american	PROPN
biomedich-91	137	46	academy	academy	PROPN
biomedich-91	137	47	of	of	ADP
biomedich-91	137	48	neurology	neurology	PROPN
biomedich-91	137	49	.	.	PUNCT
biomedich-91	138	1	neurology	neurology	NOUN
biomedich-91	138	2	,	,	PUNCT
biomedich-91	138	3	74	74	NUM
biomedich-91	138	4	:	:	SYM
biomedich-91	138	5	173–6	173–6	NUM
biomedich-91	138	6	.	.	PUNCT
biomedich-91	139	1	dunk	dunk	PROPN
biomedich-91	139	2	aa	aa	PROPN
biomedich-91	139	3	,	,	PUNCT
biomedich-91	139	4	walt	walt	PROPN
biomedich-91	139	5	rp	rp	PROPN
biomedich-91	139	6	,	,	PUNCT
biomedich-91	139	7	jenkins	jenkins	PROPN
biomedich-91	139	8	wj	wj	PROPN
biomedich-91	139	9	,	,	PUNCT
biomedich-91	139	10	sherlock	sherlock	PROPN
biomedich-91	139	11	ss	ss	PROPN
biomedich-91	139	12	,	,	PUNCT
biomedich-91	139	13	(	(	PUNCT
biomedich-91	139	14	1982	1982	NUM
biomedich-91	139	15	)	)	PUNCT
biomedich-91	139	16	.	.	PUNCT
biomedich-91	140	1	diclofenac	diclofenac	ADJ
biomedich-91	140	2	hepatitis	hepatitis	NOUN
biomedich-91	140	3	.	.	PUNCT
biomedich-91	141	1	br	br	PROPN
biomedich-91	141	2	.	.	PUNCT
biomedich-91	141	3	med	med	PROPN
biomedich-91	141	4	.	.	PUNCT
biomedich-91	142	1	j.	j.	PROPN
biomedich-91	142	2	284	284	NUM
biomedich-91	142	3	:	:	PUNCT
biomedich-91	142	4	160	160	NUM
biomedich-91	142	5	-	-	SYM
biomedich-91	142	6	166	166	NUM
biomedich-91	142	7	el	el	NOUN
biomedich-91	142	8	-	-	PUNCT
biomedich-91	142	9	wessemy	wessemy	NOUN
biomedich-91	142	10	a	a	DET
biomedich-91	142	11	m.	m.	NOUN
biomedich-91	142	12	(	(	PUNCT
biomedich-91	142	13	2008	2008	NUM
biomedich-91	142	14	)	)	PUNCT
biomedich-91	142	15	.	.	PUNCT
biomedich-91	143	1	histopathological	histopathological	ADJ
biomedich-91	143	2	and	and	CCONJ
biomedich-91	143	3	ultra	ultra	ADJ
biomedich-91	143	4	-	-	ADJ
biomedich-91	143	5	structural	structural	ADJ
biomedich-91	143	6	studies	study	NOUN
biomedich-91	143	7	on	on	ADP
biomedich-91	143	8	the	the	DET
biomedich-91	143	9	side	side	NOUN
biomedich-91	143	10	effects	effect	NOUN
biomedich-91	143	11	of	of	ADP
biomedich-91	143	12	the	the	DET
biomedich-91	143	13	analgesic	analgesic	ADJ
biomedich-91	143	14	drug	drug	NOUN
biomedich-91	143	15	tramadol	tramadol	NOUN
biomedich-91	143	16	on	on	ADP
biomedich-91	143	17	the	the	DET
biomedich-91	143	18	liver	liver	NOUN
biomedich-91	143	19	of	of	ADP
biomedich-91	143	20	albino	albino	NOUN
biomedich-91	143	21	mice	mouse	NOUN
biomedich-91	143	22	.	.	PUNCT
biomedich-91	144	1	egypt	egypt	PROPN
biomedich-91	144	2	.	.	PUNCT
biomedich-91	145	1	j.	j.	PROPN
biomedich-91	145	2	zool	zool	PROPN
biomedich-91	145	3	.	.	PUNCT
biomedich-91	146	1	50	50	NUM
biomedich-91	146	2	:	:	PUNCT
biomedich-91	146	3	423	423	NUM
biomedich-91	146	4	-	-	SYM
biomedich-91	146	5	442	442	NUM
biomedich-91	146	6	friedman	friedman	NOUN
biomedich-91	146	7	ls	ls	PROPN
biomedich-91	146	8	,	,	PUNCT
biomedich-91	146	9	martin	martin	PROPN
biomedich-91	146	10	p	p	X
biomedich-91	146	11	,	,	PUNCT
biomedich-91	146	12	munoz	munoz	PROPN
biomedich-91	146	13	sj	sj	PROPN
biomedich-91	146	14	.	.	PUNCT
biomedich-91	146	15	(	(	PUNCT
biomedich-91	146	16	1996	1996	NUM
biomedich-91	146	17	)	)	PUNCT
biomedich-91	146	18	.	.	PUNCT
biomedich-91	147	1	liver	liver	NOUN
biomedich-91	147	2	function	function	NOUN
biomedich-91	147	3	tests	test	NOUN
biomedich-91	147	4	and	and	CCONJ
biomedich-91	147	5	the	the	DET
biomedich-91	147	6	objective	objective	ADJ
biomedich-91	147	7	evaluation	evaluation	NOUN
biomedich-91	147	8	of	of	ADP
biomedich-91	147	9	the	the	DET
biomedich-91	147	10	patient	patient	NOUN
biomedich-91	147	11	with	with	ADP
biomedich-91	147	12	liver	liver	NOUN
biomedich-91	147	13	disease	disease	NOUN
biomedich-91	147	14	.	.	PUNCT
biomedich-91	148	1	in	in	ADP
biomedich-91	148	2	:	:	PUNCT
biomedich-91	148	3	zakin	zakin	PROPN
biomedich-91	148	4	d	d	PROPN
biomedich-91	148	5	,	,	PUNCT
biomedich-91	148	6	boyer	boyer	PROPN
biomedich-91	148	7	td	td	NOUN
biomedich-91	148	8	,	,	PUNCT
biomedich-91	148	9	editors	editor	NOUN
biomedich-91	148	10	.	.	PUNCT
biomedich-91	149	1	hepatology	hepatology	NOUN
biomedich-91	149	2	:	:	PUNCT
biomedich-91	149	3	a	a	DET
biomedich-91	149	4	textbook	textbook	NOUN
biomedich-91	149	5	of	of	ADP
biomedich-91	149	6	liver	liver	NOUN
biomedich-91	149	7	disease	disease	NOUN
biomedich-91	149	8	.	.	PUNCT
biomedich-91	150	1	third	third	ADJ
biomedich-91	150	2	ed	ed	NOUN
biomedich-91	150	3	.	.	PUNCT
biomedich-91	151	1	wb	wb	PROPN
biomedich-91	151	2	saunders	saunders	PROPN
biomedich-91	151	3	;	;	PUNCT
biomedich-91	151	4	philadelphia	philadelphia	PROPN
biomedich-91	151	5	:	:	PUNCT
biomedich-91	151	6	pp.791	pp.791	NUM
biomedich-91	151	7	–	–	PUNCT
biomedich-91	151	8	833	833	NUM
biomedich-91	151	9	gaw	gaw	NOUN
biomedich-91	151	10	a	a	X
biomedich-91	151	11	,	,	PUNCT
biomedich-91	151	12	cowan	cowan	PROPN
biomedich-91	151	13	ra	ra	PROPN
biomedich-91	151	14	,	,	PUNCT
biomedich-91	151	15	o’reilly	o’reilly	ADV
biomedich-91	151	16	d	d	PROPN
biomedich-91	151	17	st	st	PROPN
biomedich-91	151	18	.	.	PROPN
biomedich-91	151	19	j	j	PROPN
biomedich-91	151	20	,	,	PUNCT
biomedich-91	151	21	stewart	stewart	PROPN
biomedich-91	151	22	mj	mj	PROPN
biomedich-91	151	23	,	,	PUNCT
biomedich-91	151	24	shepherd	shepherd	PROPN
biomedich-91	151	25	j.	j.	PROPN
biomedich-91	151	26	clinical	clinical	PROPN
biomedich-91	151	27	biochemistry	biochemistry	PROPN
biomedich-91	151	28	an	an	DET
biomedich-91	151	29	illustrated	illustrate	VERB
biomedich-91	151	30	colour	colour	NOUN
biomedich-91	151	31	text	text	NOUN
biomedich-91	151	32	.	.	PUNCT
biomedich-91	152	1	2nd	2nd	ADJ
biomedich-91	152	2	ed	ed	PROPN
biomedich-91	152	3	.	.	PUNCT
biomedich-91	153	1	edinburgh	edinburgh	PROPN
biomedich-91	153	2	:	:	PUNCT
biomedich-91	153	3	harcourt	harcourt	PROPN
biomedich-91	153	4	brace	brace	PROPN
biomedich-91	153	5	;	;	PUNCT
biomedich-91	153	6	1999	1999	NUM
biomedich-91	153	7	.	.	PUNCT
biomedich-91	154	1	p.	p.	NOUN
biomedich-91	154	2	165	165	NUM
biomedich-91	155	1	gornall	gornall	NOUN
biomedich-91	155	2	a	a	DET
biomedich-91	155	3	g	g	NOUN
biomedich-91	155	4	,	,	PUNCT
biomedich-91	155	5	bardawill	bardawill	PROPN
biomedich-91	155	6	c	c	PROPN
biomedich-91	155	7	j	j	PROPN
biomedich-91	155	8	and	and	CCONJ
biomedich-91	155	9	david	david	PROPN
biomedich-91	155	10	m	m	PROPN
biomedich-91	155	11	m.	m.	NOUN
biomedich-91	155	12	(	(	PUNCT
biomedich-91	155	13	1949	1949	NUM
biomedich-91	155	14	)	)	PUNCT
biomedich-91	155	15	.	.	PUNCT
biomedich-91	156	1	determination	determination	NOUN
biomedich-91	156	2	of	of	ADP
biomedich-91	156	3	serum	serum	NOUN
biomedich-91	156	4	proteins	protein	NOUN
biomedich-91	156	5	by	by	ADP
biomedich-91	156	6	means	mean	NOUN
biomedich-91	156	7	of	of	ADP
biomedich-91	156	8	the	the	DET
biomedich-91	156	9	biureto	biureto	NOUN
biomedich-91	156	10	reaction	reaction	NOUN
biomedich-91	156	11	.	.	PUNCT
biomedich-91	157	1	j.	j.	PROPN
biomedich-91	157	2	biol	biol	PROPN
biomedich-91	157	3	.	.	PUNCT
biomedich-91	158	1	chem.177	chem.177	ADV
biomedich-91	158	2	;	;	PUNCT
biomedich-91	158	3	751	751	NUM
biomedich-91	158	4	-	-	SYM
biomedich-91	158	5	766	766	NUM
biomedich-91	158	6	.	.	PUNCT
biomedich-91	159	1	hussein	hussein	PROPN
biomedich-91	159	2	aa	aa	PROPN
biomedich-91	159	3	,	,	PUNCT
biomedich-91	159	4	hussein	hussein	PROPN
biomedich-91	159	5	ma	ma	PROPN
biomedich-91	159	6	,	,	PUNCT
biomedich-91	159	7	gaba	gaba	PROPN
biomedich-91	159	8	ea	ea	PROPN
biomedich-91	159	9	ahmed	ahme	VERB
biomedich-91	159	10	mr	mr	PROPN
biomedich-91	159	11	(	(	PUNCT
biomedich-91	159	12	2016	2016	NUM
biomedich-91	159	13	)	)	PUNCT
biomedich-91	159	14	.	.	PUNCT
biomedich-91	160	1	hepatoprotective	hepatoprotective	ADJ
biomedich-91	160	2	effects	effect	NOUN
biomedich-91	160	3	of	of	ADP
biomedich-91	160	4	cranberry	cranberry	NOUN
biomedich-91	160	5	extract	extract	NOUN
biomedich-91	160	6	against	against	ADP
biomedich-91	160	7	diclofenac	diclofenac	ADJ
biomedich-91	160	8	sodium	sodium	NOUN
biomedich-91	160	9	induced	induce	VERB
biomedich-91	160	10	liver	liver	NOUN
biomedich-91	160	11	toxicity	toxicity	NOUN
biomedich-91	160	12	in	in	ADP
biomedich-91	160	13	rats	rat	NOUN
biomedich-91	160	14	int	int	PROPN
biomedich-91	160	15	j	j	PROPN
biomedich-91	160	16	pharma	pharma	PROPN
biomedich-91	160	17	sci	sci	PROPN
biomedich-91	160	18	6	6	NUM
biomedich-91	160	19	:	:	SYM
biomedich-91	160	20	1447	1447	NUM
biomedich-91	160	21	-	-	SYM
biomedich-91	160	22	1453	1453	NUM
biomedich-91	160	23	jafari	jafari	PROPN
biomedich-91	160	24	m	m	PROPN
biomedich-91	160	25	,	,	PUNCT
biomedich-91	160	26	salehi	salehi	PROPN
biomedich-91	160	27	m	m	PROPN
biomedich-91	160	28	,	,	PUNCT
biomedich-91	160	29	ahmadi	ahmadi	PROPN
biomedich-91	160	30	s	s	PROPN
biomedich-91	160	31	,	,	PUNCT
biomedich-91	160	32	asgari	asgari	PROPN
biomedich-91	160	33	a	a	NOUN
biomedich-91	160	34	,	,	PUNCT
biomedich-91	160	35	abasnezhad	abasnezhad	PROPN
biomedich-91	160	36	m	m	PROPN
biomedich-91	160	37	,	,	PUNCT
biomedich-91	160	38	hajigholamali	hajigholamali	ADJ
biomedich-91	160	39	m.	m.	NOUN
biomedich-91	160	40	(	(	PUNCT
biomedich-91	160	41	2012	2012	NUM
biomedich-91	160	42	)	)	PUNCT
biomedich-91	160	43	.	.	PUNCT
biomedich-91	161	1	the	the	DET
biomedich-91	161	2	role	role	NOUN
biomedich-91	161	3	of	of	ADP
biomedich-91	161	4	oxidative	oxidative	ADJ
biomedich-91	161	5	stress	stress	NOUN
biomedich-91	161	6	in	in	ADP
biomedich-91	161	7	diazinon	diazinon	NOUN
biomedich-91	161	8	-	-	PUNCT
biomedich-91	161	9	induced	induce	VERB
biomedich-91	161	10	tissues	tissue	NOUN
biomedich-91	161	11	toxicity	toxicity	NOUN
biomedich-91	161	12	in	in	ADP
biomedich-91	161	13	wistar	wistar	PROPN
biomedich-91	161	14	and	and	CCONJ
biomedich-91	161	15	norway	norway	PROPN
biomedich-91	161	16	rats.toxicol	rats.toxicol	NUM
biomedich-91	161	17	mech	mech	NOUN
biomedich-91	161	18	methods	method	NOUN
biomedich-91	161	19	,	,	PUNCT
biomedich-91	161	20	22:638	22:638	NUM
biomedich-91	161	21	-	-	SYM
biomedich-91	161	22	47	47	NUM
biomedich-91	161	23	.	.	PUNCT
biomedich-91	162	1	jain	jain	PROPN
biomedich-91	162	2	r	r	PROPN
biomedich-91	162	3	,	,	PUNCT
biomedich-91	162	4	nandakumar	nandakumar	PROPN
biomedich-91	162	5	k	k	PROPN
biomedich-91	162	6	,	,	PUNCT
biomedich-91	162	7	srivastava1	srivastava1	NOUN
biomedich-91	162	8	v	v	NOUN
biomedich-91	162	9	,	,	PUNCT
biomedich-91	162	10	vaidya	vaidya	PROPN
biomedich-91	162	11	sk	sk	PROPN
biomedich-91	162	12	,	,	PUNCT
biomedich-91	162	13	patet	patet	NOUN
biomedich-91	162	14	s	s	PROPN
biomedich-91	162	15	,	,	PUNCT
biomedich-91	162	16	kumar	kumar	PROPN
biomedich-91	162	17	p.	p.	PROPN
biomedich-91	162	18	(	(	PUNCT
biomedich-91	162	19	2008	2008	NUM
biomedich-91	162	20	)	)	PUNCT
biomedich-91	162	21	.	.	PUNCT
biomedich-91	163	1	hepatoprotective	hepatoprotective	ADJ
biomedich-91	163	2	activity	activity	NOUN
biomedich-91	163	3	of	of	ADP
biomedich-91	163	4	ethanolic	ethanolic	ADJ
biomedich-91	163	5	and	and	CCONJ
biomedich-91	163	6	aqueous	aqueous	ADJ
biomedich-91	163	7	extract	extract	NOUN
biomedich-91	163	8	of	of	ADP
biomedich-91	163	9	terminalia	terminalia	PROPN
biomedich-91	163	10	belerica	belerica	VERB
biomedich-91	163	11	in	in	ADP
biomedich-91	163	12	rats	rat	NOUN
biomedich-91	163	13	.	.	PUNCT
biomedich-91	164	1	pharmacol	pharmacol	PROPN
biomedich-91	164	2	onli	onli	PROPN
biomedich-91	164	3	2	2	NUM
biomedich-91	164	4	:	:	PUNCT
biomedich-91	164	5	411	411	NUM
biomedich-91	164	6	;	;	PUNCT
biomedich-91	164	7	427	427	NUM
biomedich-91	164	8	loughrey	loughrey	NOUN
biomedich-91	164	9	mb	mb	NOUN
biomedich-91	164	10	,	,	PUNCT
biomedich-91	164	11	loughrey	loughrey	PROPN
biomedich-91	164	12	cm	cm	PROPN
biomedich-91	164	13	,	,	PUNCT
biomedich-91	164	14	johnston	johnston	PROPN
biomedich-91	164	15	s	s	PROPN
biomedich-91	164	16	,	,	PUNCT
biomedich-91	164	17	o'rourke	o'rourke	PROPN
biomedich-91	164	18	d.	d.	PROPN
biomedich-91	164	19	(	(	PUNCT
biomedich-91	164	20	2003	2003	NUM
biomedich-91	164	21	)	)	PUNCT
biomedich-91	164	22	.	.	PUNCT
biomedich-91	165	1	fatal	fatal	ADJ
biomedich-91	165	2	hepatic	hepatic	ADJ
biomedich-91	165	3	failure	failure	NOUN
biomedich-91	165	4	following	follow	VERB
biomedich-91	165	5	accidental	accidental	ADJ
biomedich-91	165	6	tramadol	tramadol	NOUN
biomedich-91	165	7	overdose	overdose	ADV
biomedich-91	165	8	.	.	PUNCT
biomedich-91	166	1	forensic	forensic	ADJ
biomedich-91	166	2	sci	sci	PROPN
biomedich-91	166	3	int	int	NOUN
biomedich-91	166	4	,	,	PUNCT
biomedich-91	166	5	134	134	NUM
biomedich-91	166	6	:	:	SYM
biomedich-91	166	7	232	232	NUM
biomedich-91	166	8	-	-	SYM
biomedich-91	166	9	3	3	NUM
biomedich-91	166	10	.	.	PUNCT
biomedich-91	167	1	mitra	mitra	PROPN
biomedich-91	167	2	s	s	PROPN
biomedich-91	167	3	,	,	PUNCT
biomedich-91	167	4	khandelwal	khandelwal	PROPN
biomedich-91	167	5	p	p	PROPN
biomedich-91	167	6	,	,	PUNCT
biomedich-91	167	7	sehgal	sehgal	ADJ
biomedich-91	167	8	a.	a.	NOUN
biomedich-91	167	9	(	(	PUNCT
biomedich-91	167	10	2012	2012	NUM
biomedich-91	167	11	)	)	PUNCT
biomedich-91	167	12	.	.	PUNCT
biomedich-91	168	1	diclofenac	diclofenac	NOUN
biomedich-91	168	2	-	-	PUNCT
biomedich-91	168	3	tramadol	tramadol	NOUN
biomedich-91	168	4	vs.	vs.	ADP
biomedich-91	168	5	diclofenac	diclofenac	NOUN
biomedich-91	168	6	-	-	PUNCT
biomedich-91	168	7	acetaminophen	acetaminophen	NOUN
biomedich-91	168	8	combinations	combination	NOUN
biomedich-91	168	9	for	for	ADP
biomedich-91	168	10	pain	pain	NOUN
biomedich-91	168	11	relief	relief	NOUN
biomedich-91	168	12	after	after	ADP
biomedich-91	168	13	caesarean	caesarean	ADJ
biomedich-91	168	14	section	section	NOUN
biomedich-91	168	15	.	.	PUNCT
biomedich-91	169	1	acta	acta	PROPN
biomedich-91	169	2	anaesthesiol	anaesthesiol	PROPN
biomedich-91	169	3	scand	scand	PROPN
biomedich-91	169	4	.	.	PUNCT
biomedich-91	170	1	56:706	56:706	PROPN
biomedich-91	170	2	-	-	SYM
biomedich-91	170	3	11	11	NUM
biomedich-91	170	4	.	.	PUNCT
biomedich-91	171	1	raffa	raffa	PROPN
biomedich-91	171	2	rb	rb	PROPN
biomedich-91	171	3	.	.	PUNCT
biomedich-91	172	1	(	(	PUNCT
biomedich-91	172	2	2001	2001	NUM
biomedich-91	172	3	)	)	PUNCT
biomedich-91	172	4	.	.	PUNCT
biomedich-91	173	1	pharmacology	pharmacology	NOUN
biomedich-91	173	2	of	of	ADP
biomedich-91	173	3	oral	oral	ADJ
biomedich-91	173	4	combination	combination	NOUN
biomedich-91	173	5	analgesics	analgesic	NOUN
biomedich-91	173	6	:	:	PUNCT
biomedich-91	173	7	rational	rational	ADJ
biomedich-91	173	8	therapy	therapy	NOUN
biomedich-91	173	9	for	for	ADP
biomedich-91	173	10	pain	pain	NOUN
biomedich-91	173	11	.	.	PUNCT
biomedich-91	174	1	j	j	PROPN
biomedich-91	174	2	clin	clin	PROPN
biomedich-91	174	3	pharm	pharm	PROPN
biomedich-91	174	4	ther	ther	ADV
biomedich-91	174	5	.	.	PUNCT
biomedich-91	175	1	26(4	26(4	NUM
biomedich-91	175	2	):	):	PUNCT
biomedich-91	175	3	257–264	257–264	NUM
biomedich-91	175	4	.	.	PUNCT
biomedich-91	176	1	rawal	rawal	PROPN
biomedich-91	176	2	n	n	CCONJ
biomedich-91	176	3	,	,	PUNCT
biomedich-91	176	4	macquaire	macquaire	NOUN
biomedich-91	176	5	v	v	NOUN
biomedich-91	176	6	,	,	PUNCT
biomedich-91	176	7	catalá	catalá	ADJ
biomedich-91	176	8	e	e	NOUN
biomedich-91	176	9	,	,	PUNCT
biomedich-91	176	10	berti	berti	PROPN
biomedich-91	176	11	m	m	PROPN
biomedich-91	176	12	,	,	PUNCT
biomedich-91	176	13	costa	costa	PROPN
biomedich-91	176	14	r	r	NOUN
biomedich-91	176	15	,	,	PUNCT
biomedich-91	176	16	wietlisbach	wietlisbach	NOUN
biomedich-91	176	17	m.	m.	NOUN
biomedich-91	176	18	(	(	PUNCT
biomedich-91	176	19	2011	2011	NUM
biomedich-91	176	20	)	)	PUNCT
biomedich-91	176	21	.	.	PUNCT
biomedich-91	177	1	tramadol	tramadol	NOUN
biomedich-91	177	2	/	/	SYM
biomedich-91	177	3	paracetamol	paracetamol	NOUN
biomedich-91	177	4	combination	combination	NOUN
biomedich-91	177	5	tablet	tablet	NOUN
biomedich-91	177	6	for	for	ADP
biomedich-91	177	7	postoperative	postoperative	ADJ
biomedich-91	177	8	pain	pain	NOUN
biomedich-91	177	9	following	follow	VERB
biomedich-91	177	10	ambulatory	ambulatory	ADJ
biomedich-91	177	11	hand	hand	NOUN
biomedich-91	177	12	surgery	surgery	NOUN
biomedich-91	177	13	:	:	PUNCT
biomedich-91	177	14	a	a	DET
biomedich-91	177	15	double	double	ADJ
biomedich-91	177	16	-	-	PUNCT
biomedich-91	177	17	blind	blind	ADJ
biomedich-91	177	18	,	,	PUNCT
biomedich-91	177	19	double	double	ADJ
biomedich-91	177	20	-	-	PUNCT
biomedich-91	177	21	dummy	dummy	NOUN
biomedich-91	177	22	,	,	PUNCT
biomedich-91	177	23	randomized	randomize	VERB
biomedich-91	177	24	,	,	PUNCT
biomedich-91	177	25	parallel	parallel	ADJ
biomedich-91	177	26	-	-	PUNCT
biomedich-91	177	27	group	group	NOUN
biomedich-91	177	28	trial	trial	NOUN
biomedich-91	177	29	.	.	PUNCT
biomedich-91	178	1	j	j	PROPN
biomedich-91	178	2	pain	pain	NOUN
biomedich-91	178	3	res	re	NOUN
biomedich-91	178	4	.	.	PUNCT
biomedich-91	179	1	4:103–110	4:103–110	PROPN
biomedich-91	179	2	.	.	PUNCT
biomedich-91	180	1	rosalki	rosalki	PROPN
biomedich-91	180	2	sb	sb	PROPN
biomedich-91	180	3	,	,	PUNCT
biomedich-91	180	4	mcintyre	mcintyre	PROPN
biomedich-91	180	5	n.	n.	PROPN
biomedich-91	180	6	biochemical	biochemical	ADJ
biomedich-91	180	7	investigations	investigation	NOUN
biomedich-91	180	8	in	in	ADP
biomedich-91	180	9	the	the	DET
biomedich-91	180	10	management	management	NOUN
biomedich-91	180	11	of	of	ADP
biomedich-91	180	12	liver	liver	NOUN
biomedich-91	180	13	disease	disease	NOUN
biomedich-91	180	14	.	.	PUNCT
biomedich-91	181	1	oxford	oxford	ADJ
biomedich-91	181	2	textbook	textbook	NOUN
biomedich-91	181	3	of	of	ADP
biomedich-91	181	4	clinical	clinical	ADJ
biomedich-91	181	5	hepatology	hepatology	NOUN
biomedich-91	181	6	,	,	PUNCT
biomedich-91	181	7	2nd	2nd	ADJ
biomedich-91	181	8	ed	ed	NOUN
biomedich-91	181	9	.	.	PUNCT
biomedich-91	182	1	new	new	PROPN
biomedich-91	182	2	york	york	PROPN
biomedich-91	182	3	;	;	PUNCT
biomedich-91	182	4	oxford	oxford	PROPN
biomedich-91	182	5	university	university	PROPN
biomedich-91	182	6	press	press	NOUN
biomedich-91	182	7	,	,	PUNCT
biomedich-91	182	8	1999	1999	NUM
biomedich-91	182	9	;	;	PUNCT
biomedich-91	182	10	503	503	NUM
biomedich-91	182	11	-	-	SYM
biomedich-91	182	12	521	521	NUM
biomedich-91	182	13	.	.	PUNCT
biomedich-91	182	14	rotruck	rotruck	PROPN
biomedich-91	182	15	jt	jt	PROPN
biomedich-91	182	16	,	,	PUNCT
biomedich-91	182	17	rope	rope	PROPN
biomedich-91	182	18	al	al	PROPN
biomedich-91	182	19	,	,	PUNCT
biomedich-91	182	20	ganther	ganther	PROPN
biomedich-91	182	21	hf	hf	PROPN
biomedich-91	182	22	,	,	PUNCT
biomedich-91	182	23	swason	swason	PROPN
biomedich-91	182	24	ab	ab	PROPN
biomedich-91	182	25	.	.	PUNCT
biomedich-91	183	1	(	(	PUNCT
biomedich-91	183	2	1973	1973	NUM
biomedich-91	183	3	)	)	PUNCT
biomedich-91	183	4	.	.	PUNCT
biomedich-91	184	1	selenium	selenium	NOUN
biomedich-91	184	2	:	:	PUNCT
biomedich-91	184	3	biochemical	biochemical	ADJ
biomedich-91	184	4	role	role	NOUN
biomedich-91	184	5	as	as	ADP
biomedich-91	184	6	a	a	DET
biomedich-91	184	7	component	component	NOUN
biomedich-91	184	8	of	of	ADP
biomedich-91	184	9	glutathione	glutathione	NOUN
biomedich-91	184	10	peroxidase	peroxidase	NOUN
biomedich-91	184	11	.	.	PUNCT
biomedich-91	184	12	science,179:588–90	science,179:588–90	PUNCT
biomedich-91	185	1	rukhshanda	rukhshanda	PROPN
biomedich-91	185	2	s	s	NOUN
biomedich-91	185	3	,	,	PUNCT
biomedich-91	185	4	razia	razia	PROPN
biomedich-91	185	5	i	i	PRON
biomedich-91	185	6	,	,	PUNCT
biomedich-91	185	7	muhammad	muhammad	PROPN
biomedich-91	185	8	na	na	PROPN
biomedich-91	185	9	,	,	PUNCT
biomedich-91	185	10	anum	anum	PROPN
biomedich-91	185	11	z	z	PROPN
biomedich-91	185	12	,	,	PUNCT
biomedich-91	185	13	javed	javed	ADJ
biomedich-91	185	14	i	i	PROPN
biomedich-91	185	15	and	and	CCONJ
biomedich-91	185	16	muhammad	muhammad	PROPN
biomedich-91	185	17	sa	sa	PROPN
biomedich-91	185	18	.	.	PUNCT
biomedich-91	186	1	(	(	PUNCT
biomedich-91	186	2	2014	2014	NUM
biomedich-91	186	3	)	)	PUNCT
biomedich-91	186	4	.	.	PUNCT
biomedich-91	187	1	effects	effect	NOUN
biomedich-91	187	2	of	of	ADP
biomedich-91	187	3	tramadol	tramadol	NOUN
biomedich-91	187	4	on	on	ADP
biomedich-91	187	5	histopathological	histopathological	ADJ
biomedich-91	187	6	and	and	CCONJ
biomedich-91	187	7	biochemical	biochemical	ADJ
biomedich-91	187	8	parameters	parameter	NOUN
biomedich-91	187	9	in	in	ADP
biomedich-91	187	10	mice	mouse	NOUN
biomedich-91	187	11	(	(	PUNCT
biomedich-91	187	12	musmusculus	musmusculus	X
biomedich-91	187	13	)	)	PUNCT
biomedich-91	187	14	model.global	model.global	PROPN
biomedich-91	187	15	j	j	PROPN
biomedich-91	187	16	pharmacol.1:14	pharmacol.1:14	NOUN
biomedich-91	187	17	-	-	PUNCT
biomedich-91	187	18	19	19	NUM
biomedich-91	187	19	.	.	PUNCT
biomedich-91	188	1	saukkonen	saukkonen	PROPN
biomedich-91	188	2	jj	jj	PROPN
biomedich-91	188	3	,	,	PUNCT
biomedich-91	188	4	cohn	cohn	PROPN
biomedich-91	188	5	dl	dl	PROPN
biomedich-91	188	6	,	,	PUNCT
biomedich-91	188	7	jasmer	jasmer	PROPN
biomedich-91	188	8	rm	rm	PROPN
biomedich-91	188	9	,	,	PUNCT
biomedich-91	188	10	schenker	schenker	PROPN
biomedich-91	188	11	s	s	PROPN
biomedich-91	188	12	,	,	PUNCT
biomedich-91	188	13	jereb	jereb	PROPN
biomedich-91	188	14	ja	ja	PROPN
biomedich-91	188	15	,	,	PUNCT
biomedich-91	188	16	et	et	PROPN
biomedich-91	188	17	al	al	PROPN
biomedich-91	188	18	.	.	PUNCT
biomedich-91	188	19	(	(	PUNCT
biomedich-91	188	20	2006	2006	NUM
biomedich-91	188	21	)	)	PUNCT
biomedich-91	188	22	.	.	PUNCT
biomedich-91	189	1	an	an	DET
biomedich-91	189	2	official	official	ADJ
biomedich-91	189	3	ats	ats	PROPN
biomedich-91	189	4	statement	statement	NOUN
biomedich-91	189	5	:	:	PUNCT
biomedich-91	189	6	hepatotoxicity	hepatotoxicity	NOUN
biomedich-91	189	7	of	of	ADP
biomedich-91	189	8	antituberculosis	antituberculosis	NOUN
biomedich-91	189	9	therapy	therapy	NOUN
biomedich-91	189	10	.	.	PUNCT
biomedich-91	189	11	am	be	AUX
biomedich-91	189	12	j	j	PROPN
biomedich-91	189	13	respircrit	respircrit	PROPN
biomedich-91	189	14	care	care	PROPN
biomedich-91	189	15	med	med	ADJ
biomedich-91	189	16	,	,	PUNCT
biomedich-91	189	17	174	174	NUM
biomedich-91	189	18	:	:	PUNCT
biomedich-91	189	19	935	935	NUM
biomedich-91	189	20	-	-	SYM
biomedich-91	189	21	952	952	NUM
biomedich-91	189	22	.	.	PUNCT
biomedich-91	190	1	sedlak	sedlak	PROPN
biomedich-91	190	2	j	j	PROPN
biomedich-91	190	3	and	and	CCONJ
biomedich-91	190	4	lindsay	lindsay	PROPN
biomedich-91	190	5	rh	rh	PROPN
biomedich-91	190	6	.	.	PUNCT
biomedich-91	190	7	(	(	PUNCT
biomedich-91	190	8	1968	1968	NUM
biomedich-91	190	9	)	)	PUNCT
biomedich-91	190	10	.	.	PUNCT
biomedich-91	191	1	estimation	estimation	NOUN
biomedich-91	191	2	of	of	ADP
biomedich-91	191	3	total	total	NOUN
biomedich-91	191	4	,	,	PUNCT
biomedich-91	191	5	proteinbound	proteinbound	ADV
biomedich-91	191	6	,	,	PUNCT
biomedich-91	191	7	and	and	CCONJ
biomedich-91	191	8	nonprotein	nonprotein	ADV
biomedich-91	191	9	sulfhydryl	sulfhydryl	ADJ
biomedich-91	191	10	groups	group	NOUN
biomedich-91	191	11	in	in	ADP
biomedich-91	191	12	tissue	tissue	NOUN
biomedich-91	191	13	with	with	ADP
biomedich-91	191	14	ellman	ellman	NOUN
biomedich-91	191	15	’s	’s	PART
biomedich-91	191	16	reagent	reagent	NOUN
biomedich-91	191	17	.	.	PUNCT
biomedich-91	192	1	anal	anal	ADJ
biomedich-91	192	2	biochem	biochem	PROPN
biomedich-91	192	3	,	,	PUNCT
biomedich-91	192	4	25	25	NUM
biomedich-91	192	5	:	:	SYM
biomedich-91	192	6	1192	1192	NUM
biomedich-91	192	7	-	-	SYM
biomedich-91	192	8	1205	1205	NUM
biomedich-91	192	9	singhal	singhal	PROPN
biomedich-91	192	10	pc	pc	PROPN
biomedich-91	192	11	,	,	PUNCT
biomedich-91	192	12	sharma	sharma	PROPN
biomedich-91	192	13	p	p	PROPN
biomedich-91	192	14	,	,	PUNCT
biomedich-91	192	15	kapasi	kapasi	PROPN
biomedich-91	192	16	aa	aa	PROPN
biomedich-91	192	17	,	,	PUNCT
biomedich-91	192	18	reddy	reddy	PROPN
biomedich-91	192	19	k	k	PROPN
biomedich-91	192	20	,	,	PUNCT
biomedich-91	192	21	franki	franki	PROPN
biomedich-91	192	22	n	n	PROPN
biomedich-91	192	23	and	and	CCONJ
biomedich-91	192	24	gibbons	gibbon	NOUN
biomedich-91	192	25	n.	n.	PROPN
biomedich-91	192	26	(	(	PUNCT
biomedich-91	192	27	1998	1998	NUM
biomedich-91	192	28	)	)	PUNCT
biomedich-91	192	29	.	.	PUNCT
biomedich-91	193	1	morphine	morphine	NOUN
biomedich-91	193	2	enhances	enhance	VERB
biomedich-91	193	3	macrophage	macrophage	ADJ
biomedich-91	193	4	apoptosis	apoptosis	NOUN
biomedich-91	193	5	.	.	PUNCT
biomedich-91	194	1	jour	jour	PROPN
biomedich-91	194	2	.	.	PROPN
biomedich-91	194	3	of	of	ADP
biomedich-91	194	4	immunology	immunology	NOUN
biomedich-91	194	5	,	,	PUNCT
biomedich-91	194	6	160	160	NUM
biomedich-91	194	7	:	:	SYM
biomedich-91	194	8	1886	1886	NUM
biomedich-91	194	9	-	-	SYM
biomedich-91	194	10	1893	1893	NUM
biomedich-91	194	11	sun	sun	NOUN
biomedich-91	194	12	m	m	PROPN
biomedich-91	194	13	and	and	CCONJ
biomedich-91	194	14	zigma	zigma	PROPN
biomedich-91	194	15	s.	s.	PROPN
biomedich-91	194	16	(	(	PUNCT
biomedich-91	194	17	1978	1978	NUM
biomedich-91	194	18	)	)	PUNCT
biomedich-91	194	19	.	.	PUNCT
biomedich-91	195	1	animprovedspectrophotometer	animprovedspectrophotometer	PROPN
biomedich-91	195	2	assay	assay	PROPN
biomedich-91	195	3	of	of	ADP
biomedich-91	195	4	superoxide	superoxide	NOUN
biomedich-91	195	5	dismutase	dismutase	NOUN
biomedich-91	195	6	based	base	VERB
biomedich-91	195	7	on	on	ADP
biomedich-91	195	8	epinephrine	epinephrine	NOUN
biomedich-91	195	9	antioxidation	antioxidation	NOUN
biomedich-91	195	10	.	.	PUNCT
biomedich-91	196	1	anal	anal	ADJ
biomedich-91	196	2	biochem	biochem	PROPN
biomedich-91	196	3	.	.	PUNCT
biomedich-91	197	1	90	90	NUM
biomedich-91	197	2	:	:	SYM
biomedich-91	197	3	81	81	NUM
biomedich-91	197	4	-	-	SYM
biomedich-91	197	5	89	89	NUM
biomedich-91	197	6	tang	tang	PROPN
biomedich-91	197	7	w	w	PROPN
biomedich-91	197	8	,	,	PUNCT
biomedich-91	197	9	stearns	stearns	PROPN
biomedich-91	197	10	ra	ra	PROPN
biomedich-91	197	11	,	,	PUNCT
biomedich-91	197	12	bandiera	bandiera	PROPN
biomedich-91	197	13	sm	sm	PROPN
biomedich-91	197	14	,	,	PUNCT
biomedich-91	197	15	zhang	zhang	PROPN
biomedich-91	197	16	y	y	PROPN
biomedich-91	197	17	,	,	PUNCT
biomedich-91	197	18	raab	raab	PROPN
biomedich-91	197	19	c	c	PROPN
biomedich-91	197	20	,	,	PUNCT
biomedich-91	197	21	braun	braun	PROPN
biomedich-91	197	22	mp	mp	PROPN
biomedich-91	197	23	,	,	PUNCT
biomedich-91	197	24	dean	dean	PROPN
biomedich-91	197	25	dc	dc	PROPN
biomedich-91	197	26	,	,	PUNCT
biomedich-91	197	27	et	et	PROPN
biomedich-91	197	28	al	al	PROPN
biomedich-91	197	29	.	.	PUNCT
biomedich-91	197	30	(	(	PUNCT
biomedich-91	197	31	1999	1999	NUM
biomedich-91	197	32	)	)	PUNCT
biomedich-91	197	33	.	.	PUNCT
biomedich-91	198	1	studies	study	NOUN
biomedich-91	198	2	on	on	ADP
biomedich-91	198	3	cytochrome	cytochrome	ADJ
biomedich-91	198	4	p-450mediated	p-450mediate	VERB
biomedich-91	198	5	bioactivation	bioactivation	NOUN
biomedich-91	198	6	of	of	ADP
biomedich-91	198	7	diclofenac	diclofenac	NOUN
biomedich-91	198	8	in	in	ADP
biomedich-91	198	9	rats	rat	NOUN
biomedich-91	198	10	and	and	CCONJ
biomedich-91	198	11	in	in	ADP
biomedich-91	198	12	human	human	ADJ
biomedich-91	198	13	hepatocytes	hepatocyte	NOUN
biomedich-91	198	14	:	:	PUNCT
biomedich-91	198	15	identification	identification	NOUN
biomedich-91	198	16	of	of	ADP
biomedich-91	198	17	glutathione	glutathione	NOUN
biomedich-91	198	18	conjugated	conjugate	VERB
biomedich-91	198	19	metabolites	metabolite	NOUN
biomedich-91	198	20	.	.	PUNCT
biomedich-91	199	1	drug	drug	NOUN
biomedich-91	199	2	metab.dispos	metab.dispos	PROPN
biomedich-91	199	3	.	.	PUNCT
biomedich-91	200	1	27	27	NUM
biomedich-91	200	2	:	:	PUNCT
biomedich-91	200	3	365	365	NUM
biomedich-91	200	4	-	-	SYM
biomedich-91	200	5	372	372	NUM
biomedich-91	200	6	.	.	PUNCT
biomedich-91	201	1	yousef	yousef	PROPN
biomedich-91	201	2	mi	mi	PROPN
biomedich-91	201	3	,	,	PUNCT
biomedich-91	201	4	omar	omar	PROPN
biomedich-91	201	5	sa	sa	PROPN
biomedich-91	201	6	,	,	PUNCT
biomedich-91	201	7	el	el	PROPN
biomedich-91	201	8	-	-	PUNCT
biomedich-91	201	9	guendi	guendi	NOUN
biomedich-91	201	10	mi	mi	PROPN
biomedich-91	201	11	,	,	PUNCT
biomedich-91	201	12	abdelmegid	abdelmegid	PROPN
biomedich-91	201	13	la	la	PROPN
biomedich-91	201	14	.	.	PUNCT
biomedich-91	201	15	(	(	PUNCT
biomedich-91	201	16	2010	2010	NUM
biomedich-91	201	17	)	)	PUNCT
biomedich-91	201	18	.	.	PUNCT
biomedich-91	202	1	potential	potential	ADJ
biomedich-91	202	2	protective	protective	ADJ
biomedich-91	202	3	effects	effect	NOUN
biomedich-91	202	4	of	of	ADP
biomedich-91	202	5	quercetin	quercetin	NOUN
biomedich-91	202	6	and	and	CCONJ
biomedich-91	202	7	curcumin	curcumin	NOUN
biomedich-91	202	8	on	on	ADP
biomedich-91	202	9	paracetamol	paracetamol	NOUN
biomedich-91	202	10	-	-	PUNCT
biomedich-91	202	11	induced	induce	VERB
biomedich-91	202	12	histological	histological	ADJ
biomedich-91	202	13	changes	change	NOUN
biomedich-91	202	14	,	,	PUNCT
biomedich-91	202	15	oxidative	oxidative	ADJ
biomedich-91	202	16	stress	stress	NOUN
biomedich-91	202	17	,	,	PUNCT
biomedich-91	202	18	impaired	impaired	ADJ
biomedich-91	202	19	liver	liver	NOUN
biomedich-91	202	20	and	and	CCONJ
biomedich-91	202	21	kidney	kidney	NOUN
biomedich-91	202	22	functions	function	NOUN
biomedich-91	202	23	and	and	CCONJ
biomedich-91	202	24	haematotoxicity	haematotoxicity	NOUN
biomedich-91	202	25	in	in	ADP
biomedich-91	202	26	rat	rat	NOUN
biomedich-91	202	27	food	food	NOUN
biomedich-91	202	28	chem	chem	NOUN
biomedich-91	202	29	toxicol	toxicol	NOUN
biomedich-91	202	30	,	,	PUNCT
biomedich-91	202	31	48	48	NUM
biomedich-91	202	32	;	;	PUNCT
biomedich-91	202	33	3246	3246	NUM
biomedich-91	202	34	-	-	SYM
biomedich-91	202	35	3261	3261	NUM
biomedich-91	202	36	zimmerman	zimmerman	PROPN
biomedich-91	202	37	hj	hj	PROPN
biomedich-91	202	38	.	.	PROPN
biomedich-91	202	39	(	(	PUNCT
biomedich-91	202	40	1999	1999	NUM
biomedich-91	202	41	)	)	PUNCT
biomedich-91	202	42	.	.	PUNCT
biomedich-91	203	1	drugs	drug	NOUN
biomedich-91	203	2	used	use	VERB
biomedich-91	203	3	to	to	PART
biomedich-91	203	4	treat	treat	VERB
biomedich-91	203	5	rheumatic	rheumatic	ADJ
biomedich-91	203	6	and	and	CCONJ
biomedich-91	203	7	musculospastic	musculospastic	ADJ
biomedich-91	203	8	disease	disease	NOUN
biomedich-91	203	9	.	.	PUNCT
biomedich-91	204	1	the	the	DET
biomedich-91	204	2	nsaids.in	nsaids.in	NOUN
biomedich-91	204	3	,	,	PUNCT
biomedich-91	204	4	zimmerman	zimmerman	PROPN
biomedich-91	204	5	hj	hj	PROPN
biomedich-91	204	6	.	.	PUNCT
biomedich-91	204	7	hepatotoxicity	hepatotoxicity	PROPN
biomedich-91	204	8	:	:	PUNCT
biomedich-91	204	9	the	the	DET
biomedich-91	204	10	adverse	adverse	ADJ
biomedich-91	204	11	effects	effect	NOUN
biomedich-91	204	12	of	of	ADP
biomedich-91	204	13	drugs	drug	NOUN
biomedich-91	204	14	and	and	CCONJ
biomedich-91	204	15	other	other	ADJ
biomedich-91	204	16	chemicals	chemical	NOUN
biomedich-91	204	17	on	on	ADP
biomedich-91	204	18	the	the	DET
biomedich-91	204	19	liver	liver	NOUN
biomedich-91	204	20	.	.	PUNCT
biomedich-91	205	1	2nd	2nd	ADJ
biomedich-91	205	2	ed	ed	NOUN
biomedich-91	205	3	.	.	PUNCT
biomedich-91	206	1	philadelphia	philadelphia	PROPN
biomedich-91	206	2	:	:	PUNCT
biomedich-91	207	1	lippincott	lippincott	PROPN
biomedich-91	207	2	,	,	PUNCT
biomedich-91	207	3	pp	pp	PROPN
biomedich-91	207	4	.	.	PUNCT
biomedich-91	207	5	1999	1999	NUM
biomedich-91	207	6	;	;	PUNCT
biomedich-91	207	7	517	517	NUM
biomedich-91	207	8	-	-	SYM
biomedich-91	207	9	41	41	NUM
biomedich-91	207	10	.	.	PUNCT