id	sid	tid	token	lemma	pos
biomedich-945	1	1	biology	biology	NOUN
biomedich-945	1	2	,	,	PUNCT
biomedich-945	1	3	medicine	medicine	NOUN
biomedich-945	1	4	,	,	PUNCT
biomedich-945	1	5	&	&	CCONJ
biomedich-945	1	6	natural	natural	ADJ
biomedich-945	1	7	product	product	NOUN
biomedich-945	1	8	chemistry	chemistry	NOUN
biomedich-945	1	9	issn	issn	VERB
biomedich-945	1	10	2089	2089	NUM
biomedich-945	1	11	-	-	SYM
biomedich-945	1	12	6514	6514	NUM
biomedich-945	1	13	(	(	PUNCT
biomedich-945	1	14	paper	paper	NOUN
biomedich-945	1	15	)	)	PUNCT
biomedich-945	1	16	volume	volume	NOUN
biomedich-945	1	17	14	14	NUM
biomedich-945	1	18	,	,	PUNCT
biomedich-945	1	19	number	number	NOUN
biomedich-945	1	20	2	2	NUM
biomedich-945	1	21	,	,	PUNCT
biomedich-945	1	22	october	october	PROPN
biomedich-945	1	23	2025	2025	NUM
biomedich-945	1	24	|	|	ADV
biomedich-945	1	25	pages	page	NOUN
biomedich-945	1	26	:	:	PUNCT
biomedich-945	1	27	873	873	NUM
biomedich-945	1	28	-	-	SYM
biomedich-945	1	29	878	878	NUM
biomedich-945	1	30	|	|	ADV
biomedich-945	1	31	doi	doi	NOUN
biomedich-945	1	32	:	:	PUNCT
biomedich-945	1	33	10.14421	10.14421	NUM
biomedich-945	1	34	/	/	SYM
biomedich-945	1	35	biomedich.2025.142.873	biomedich.2025.142.873	NOUN
biomedich-945	1	36	-	-	SYM
biomedich-945	1	37	878	878	NUM
biomedich-945	1	38	issn	issn	PROPN
biomedich-945	1	39	2540	2540	NUM
biomedich-945	1	40	-	-	SYM
biomedich-945	1	41	9328	9328	NUM
biomedich-945	1	42	(	(	PUNCT
biomedich-945	1	43	online	online	ADJ
biomedich-945	1	44	)	)	PUNCT
biomedich-945	1	45	effect	effect	NOUN
biomedich-945	1	46	of	of	ADP
biomedich-945	1	47	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	1	48	administration	administration	NOUN
biomedich-945	1	49	on	on	ADP
biomedich-945	1	50	gastric	gastric	ADJ
biomedich-945	1	51	histopathological	histopathological	ADJ
biomedich-945	1	52	changes	change	NOUN
biomedich-945	1	53	in	in	ADP
biomedich-945	1	54	mice	mouse	NOUN
biomedich-945	1	55	lisa	lisa	PROPN
biomedich-945	1	56	savitri1	savitri1	PROPN
biomedich-945	1	57	*	*	PROPN
biomedich-945	1	58	,	,	PUNCT
biomedich-945	1	59	kharisul	kharisul	NOUN
biomedich-945	1	60	ihsan2	ihsan2	PROPN
biomedich-945	1	61	,	,	PUNCT
biomedich-945	1	62	rochmad	rochmad	ADJ
biomedich-945	1	63	krissanjaya1	krissanjaya1	NOUN
biomedich-945	1	64	,	,	PUNCT
biomedich-945	1	65	elfred	elfred	ADJ
biomedich-945	1	66	rinaldo	rinaldo	ADJ
biomedich-945	1	67	kasimo1	kasimo1	PROPN
biomedich-945	1	68	,	,	PUNCT
biomedich-945	1	69	novirma	novirma	NOUN
biomedich-945	1	70	yanti1	yanti1	PROPN
biomedich-945	1	71	,	,	PUNCT
biomedich-945	1	72	mochamad	mochamad	NOUN
biomedich-945	1	73	hanif	hanif	PROPN
biomedich-945	1	74	hilmi1	hilmi1	PROPN
biomedich-945	1	75	1department	1department	NUM
biomedich-945	1	76	of	of	ADP
biomedich-945	1	77	medical	medical	ADJ
biomedich-945	1	78	laboratory	laboratory	NOUN
biomedich-945	1	79	technology	technology	NOUN
biomedich-945	1	80	,	,	PUNCT
biomedich-945	1	81	faculty	faculty	NOUN
biomedich-945	1	82	of	of	ADP
biomedich-945	1	83	health	health	NOUN
biomedich-945	1	84	sciences	sciences	PROPN
biomedich-945	1	85	,	,	PUNCT
biomedich-945	1	86	kadiri	kadiri	PROPN
biomedich-945	1	87	university	university	PROPN
biomedich-945	1	88	,	,	PUNCT
biomedich-945	1	89	kediri	kediri	PROPN
biomedich-945	1	90	,	,	PUNCT
biomedich-945	1	91	east	east	PROPN
biomedich-945	1	92	java	java	PROPN
biomedich-945	1	93	,	,	PUNCT
biomedich-945	1	94	indonesia	indonesia	PROPN
biomedich-945	1	95	2department	2department	NUM
biomedich-945	1	96	of	of	ADP
biomedich-945	1	97	pharmacy	pharmacy	NOUN
biomedich-945	1	98	,	,	PUNCT
biomedich-945	1	99	faculty	faculty	NOUN
biomedich-945	1	100	of	of	ADP
biomedich-945	1	101	pharmacy	pharmacy	NOUN
biomedich-945	1	102	,	,	PUNCT
biomedich-945	1	103	public	public	ADJ
biomedich-945	1	104	health	health	NOUN
biomedich-945	1	105	,	,	PUNCT
biomedich-945	1	106	hospital	hospital	NOUN
biomedich-945	1	107	administration	administration	NOUN
biomedich-945	1	108	,	,	PUNCT
biomedich-945	1	109	radiology	radiology	NOUN
biomedich-945	1	110	,	,	PUNCT
biomedich-945	1	111	universitas	universitas	PROPN
biomedich-945	1	112	strada	strada	PROPN
biomedich-945	1	113	indonesia	indonesia	PROPN
biomedich-945	1	114	,	,	PUNCT
biomedich-945	1	115	kediri	kediri	PROPN
biomedich-945	1	116	,	,	PUNCT
biomedich-945	1	117	east	east	PROPN
biomedich-945	1	118	jawa	jawa	PROPN
biomedich-945	1	119	,	,	PUNCT
biomedich-945	1	120	indonesia	indonesia	PROPN
biomedich-945	1	121	corresponding	correspond	VERB
biomedich-945	1	122	author	author	NOUN
biomedich-945	1	123	*	*	PUNCT
biomedich-945	1	124	lisasavitri@unik-kediri.ac.id	lisasavitri@unik-kediri.ac.id	ADJ
biomedich-945	1	125	manuscript	manuscript	NOUN
biomedich-945	1	126	received	receive	VERB
biomedich-945	1	127	:	:	PUNCT
biomedich-945	1	128	30	30	NUM
biomedich-945	1	129	august	august	NOUN
biomedich-945	1	130	,	,	PUNCT
biomedich-945	1	131	2025	2025	NUM
biomedich-945	1	132	.	.	PUNCT
biomedich-945	2	1	revision	revision	NOUN
biomedich-945	2	2	accepted	accept	VERB
biomedich-945	2	3	:	:	PUNCT
biomedich-945	2	4	14	14	NUM
biomedich-945	2	5	october	october	PROPN
biomedich-945	2	6	,	,	PUNCT
biomedich-945	2	7	2025	2025	NUM
biomedich-945	2	8	.	.	PUNCT
biomedich-945	3	1	published	publish	VERB
biomedich-945	3	2	:	:	PUNCT
biomedich-945	3	3	24	24	NUM
biomedich-945	3	4	october	october	PROPN
biomedich-945	3	5	,	,	PUNCT
biomedich-945	3	6	2025	2025	NUM
biomedich-945	3	7	.	.	PUNCT
biomedich-945	4	1	abstract	abstract	ADJ
biomedich-945	4	2	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	4	3	is	be	AUX
biomedich-945	4	4	a	a	DET
biomedich-945	4	5	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	4	6	antibiotic	antibiotic	NOUN
biomedich-945	4	7	widely	widely	ADV
biomedich-945	4	8	used	use	VERB
biomedich-945	4	9	in	in	ADP
biomedich-945	4	10	clinical	clinical	ADJ
biomedich-945	4	11	and	and	CCONJ
biomedich-945	4	12	veterinary	veterinary	ADJ
biomedich-945	4	13	practice	practice	NOUN
biomedich-945	4	14	.	.	PUNCT
biomedich-945	5	1	while	while	SCONJ
biomedich-945	5	2	effective	effective	ADJ
biomedich-945	5	3	against	against	ADP
biomedich-945	5	4	a	a	DET
biomedich-945	5	5	broad	broad	ADJ
biomedich-945	5	6	range	range	NOUN
biomedich-945	5	7	of	of	ADP
biomedich-945	5	8	bacterial	bacterial	ADJ
biomedich-945	5	9	infections	infection	NOUN
biomedich-945	5	10	,	,	PUNCT
biomedich-945	5	11	several	several	ADJ
biomedich-945	5	12	studies	study	NOUN
biomedich-945	5	13	have	have	AUX
biomedich-945	5	14	reported	report	VERB
biomedich-945	5	15	potential	potential	ADJ
biomedich-945	5	16	adverse	adverse	ADJ
biomedich-945	5	17	effects	effect	NOUN
biomedich-945	5	18	on	on	ADP
biomedich-945	5	19	the	the	DET
biomedich-945	5	20	gastrointestinal	gastrointestinal	ADJ
biomedich-945	5	21	tract	tract	NOUN
biomedich-945	5	22	,	,	PUNCT
biomedich-945	5	23	particularly	particularly	ADV
biomedich-945	5	24	the	the	DET
biomedich-945	5	25	gastric	gastric	ADJ
biomedich-945	5	26	mucosa	mucosa	NOUN
biomedich-945	5	27	.	.	PUNCT
biomedich-945	6	1	this	this	DET
biomedich-945	6	2	study	study	NOUN
biomedich-945	6	3	aimed	aim	VERB
biomedich-945	6	4	to	to	PART
biomedich-945	6	5	evaluate	evaluate	VERB
biomedich-945	6	6	the	the	DET
biomedich-945	6	7	histopathological	histopathological	ADJ
biomedich-945	6	8	changes	change	NOUN
biomedich-945	6	9	in	in	ADP
biomedich-945	6	10	the	the	DET
biomedich-945	6	11	gastric	gastric	ADJ
biomedich-945	6	12	mucosa	mucosa	NOUN
biomedich-945	6	13	of	of	ADP
biomedich-945	6	14	mice	mouse	NOUN
biomedich-945	6	15	following	follow	VERB
biomedich-945	6	16	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	6	17	administration	administration	NOUN
biomedich-945	6	18	at	at	ADP
biomedich-945	6	19	different	different	ADJ
biomedich-945	6	20	doses	dose	NOUN
biomedich-945	6	21	.	.	PUNCT
biomedich-945	7	1	a	a	DET
biomedich-945	7	2	total	total	NOUN
biomedich-945	7	3	of	of	ADP
biomedich-945	7	4	24	24	NUM
biomedich-945	7	5	male	male	ADJ
biomedich-945	7	6	mice	mouse	NOUN
biomedich-945	7	7	were	be	AUX
biomedich-945	7	8	randomly	randomly	ADV
biomedich-945	7	9	divided	divide	VERB
biomedich-945	7	10	into	into	ADP
biomedich-945	7	11	four	four	NUM
biomedich-945	7	12	groups	group	NOUN
biomedich-945	7	13	:	:	PUNCT
biomedich-945	7	14	control	control	NOUN
biomedich-945	7	15	,	,	PUNCT
biomedich-945	7	16	low	low	ADJ
biomedich-945	7	17	-	-	PUNCT
biomedich-945	7	18	dose	dose	NOUN
biomedich-945	7	19	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	7	20	,	,	PUNCT
biomedich-945	7	21	moderate	moderate	ADJ
biomedich-945	7	22	-	-	PUNCT
biomedich-945	7	23	dose	dose	NOUN
biomedich-945	7	24	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	7	25	,	,	PUNCT
biomedich-945	7	26	and	and	CCONJ
biomedich-945	7	27	high	high	ADJ
biomedich-945	7	28	-	-	PUNCT
biomedich-945	7	29	dose	dose	NOUN
biomedich-945	7	30	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	7	31	.	.	PUNCT
biomedich-945	8	1	treatment	treatment	NOUN
biomedich-945	8	2	was	be	AUX
biomedich-945	8	3	administered	administer	VERB
biomedich-945	8	4	orally	orally	ADV
biomedich-945	8	5	for	for	ADP
biomedich-945	8	6	14	14	NUM
biomedich-945	8	7	days	day	NOUN
biomedich-945	8	8	.	.	PUNCT
biomedich-945	9	1	gastric	gastric	ADJ
biomedich-945	9	2	tissues	tissue	NOUN
biomedich-945	9	3	were	be	AUX
biomedich-945	9	4	collected	collect	VERB
biomedich-945	9	5	and	and	CCONJ
biomedich-945	9	6	examined	examine	VERB
biomedich-945	9	7	histologically	histologically	ADV
biomedich-945	9	8	using	use	VERB
biomedich-945	9	9	hematoxylin	hematoxylin	NOUN
biomedich-945	9	10	-	-	PUNCT
biomedich-945	9	11	eosin	eosin	NOUN
biomedich-945	9	12	staining	stain	VERB
biomedich-945	9	13	.	.	PUNCT
biomedich-945	10	1	histopathological	histopathological	ADJ
biomedich-945	10	2	analysis	analysis	NOUN
biomedich-945	10	3	revealed	reveal	VERB
biomedich-945	10	4	dose	dose	NOUN
biomedich-945	10	5	-	-	PUNCT
biomedich-945	10	6	dependent	dependent	ADJ
biomedich-945	10	7	mucosal	mucosal	NOUN
biomedich-945	10	8	alterations	alteration	NOUN
biomedich-945	10	9	.	.	PUNCT
biomedich-945	11	1	the	the	DET
biomedich-945	11	2	control	control	NOUN
biomedich-945	11	3	group	group	NOUN
biomedich-945	11	4	showed	show	VERB
biomedich-945	11	5	intact	intact	ADJ
biomedich-945	11	6	gastric	gastric	ADJ
biomedich-945	11	7	architecture	architecture	NOUN
biomedich-945	11	8	,	,	PUNCT
biomedich-945	11	9	while	while	SCONJ
biomedich-945	11	10	the	the	DET
biomedich-945	11	11	low	low	ADV
biomedich-945	11	12	-	-	PUNCT
biomedich-945	11	13	dose	dose	NOUN
biomedich-945	11	14	group	group	NOUN
biomedich-945	11	15	exhibited	exhibit	VERB
biomedich-945	11	16	mild	mild	ADJ
biomedich-945	11	17	epithelial	epithelial	ADJ
biomedich-945	11	18	erosion	erosion	NOUN
biomedich-945	11	19	.	.	PUNCT
biomedich-945	12	1	the	the	DET
biomedich-945	12	2	moderate	moderate	ADJ
biomedich-945	12	3	-	-	PUNCT
biomedich-945	12	4	dose	dose	NOUN
biomedich-945	12	5	group	group	NOUN
biomedich-945	12	6	presented	present	VERB
biomedich-945	12	7	with	with	ADP
biomedich-945	12	8	mucosal	mucosal	ADJ
biomedich-945	12	9	disruption	disruption	NOUN
biomedich-945	12	10	and	and	CCONJ
biomedich-945	12	11	inflammatory	inflammatory	ADJ
biomedich-945	12	12	infiltration	infiltration	NOUN
biomedich-945	12	13	,	,	PUNCT
biomedich-945	12	14	and	and	CCONJ
biomedich-945	12	15	the	the	DET
biomedich-945	12	16	high	high	ADJ
biomedich-945	12	17	-	-	PUNCT
biomedich-945	12	18	dose	dose	NOUN
biomedich-945	12	19	group	group	NOUN
biomedich-945	12	20	demonstrated	demonstrate	VERB
biomedich-945	12	21	severe	severe	ADJ
biomedich-945	12	22	ulceration	ulceration	NOUN
biomedich-945	12	23	,	,	PUNCT
biomedich-945	12	24	edema	edema	NOUN
biomedich-945	12	25	,	,	PUNCT
biomedich-945	12	26	and	and	CCONJ
biomedich-945	12	27	mucosal	mucosal	NOUN
biomedich-945	12	28	thinning	thinning	NOUN
biomedich-945	12	29	.	.	PUNCT
biomedich-945	13	1	these	these	DET
biomedich-945	13	2	findings	finding	NOUN
biomedich-945	13	3	indicate	indicate	VERB
biomedich-945	13	4	progressive	progressive	ADJ
biomedich-945	13	5	gastric	gastric	ADJ
biomedich-945	13	6	injury	injury	NOUN
biomedich-945	13	7	with	with	ADP
biomedich-945	13	8	increasing	increase	VERB
biomedich-945	13	9	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	13	10	exposure	exposure	NOUN
biomedich-945	13	11	.	.	PUNCT
biomedich-945	14	1	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	14	2	administration	administration	PROPN
biomedich-945	14	3	induces	induce	VERB
biomedich-945	14	4	dose	dose	NOUN
biomedich-945	14	5	-	-	PUNCT
biomedich-945	14	6	dependent	dependent	ADJ
biomedich-945	14	7	gastric	gastric	ADJ
biomedich-945	14	8	mucosal	mucosal	NOUN
biomedich-945	14	9	injury	injury	NOUN
biomedich-945	14	10	in	in	ADP
biomedich-945	14	11	mice	mouse	NOUN
biomedich-945	14	12	,	,	PUNCT
biomedich-945	14	13	consistent	consistent	ADJ
biomedich-945	14	14	with	with	ADP
biomedich-945	14	15	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	14	16	-	-	PUNCT
biomedich-945	14	17	related	relate	VERB
biomedich-945	14	18	gastrointestinal	gastrointestinal	ADJ
biomedich-945	14	19	toxicity	toxicity	NOUN
biomedich-945	14	20	.	.	PUNCT
biomedich-945	15	1	caution	caution	NOUN
biomedich-945	15	2	is	be	AUX
biomedich-945	15	3	warranted	warrant	VERB
biomedich-945	15	4	in	in	ADP
biomedich-945	15	5	prolonged	prolonged	ADJ
biomedich-945	15	6	or	or	CCONJ
biomedich-945	15	7	high	high	ADV
biomedich-945	15	8	-	-	PUNCT
biomedich-945	15	9	dose	dose	NOUN
biomedich-945	15	10	therapy	therapy	NOUN
biomedich-945	15	11	,	,	PUNCT
biomedich-945	15	12	and	and	CCONJ
biomedich-945	15	13	further	further	ADJ
biomedich-945	15	14	studies	study	NOUN
biomedich-945	15	15	are	be	AUX
biomedich-945	15	16	needed	need	VERB
biomedich-945	15	17	to	to	PART
biomedich-945	15	18	explore	explore	VERB
biomedich-945	15	19	the	the	DET
biomedich-945	15	20	underlying	underlying	ADJ
biomedich-945	15	21	mechanisms	mechanism	NOUN
biomedich-945	15	22	and	and	CCONJ
biomedich-945	15	23	potential	potential	ADJ
biomedich-945	15	24	gastroprotective	gastroprotective	NOUN
biomedich-945	15	25	interventions	intervention	NOUN
biomedich-945	15	26	.	.	PUNCT
biomedich-945	16	1	keywords	keyword	NOUN
biomedich-945	16	2	:	:	PUNCT
biomedich-945	16	3	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	16	4	;	;	PUNCT
biomedich-945	16	5	gastric	gastric	ADJ
biomedich-945	16	6	mucosa	mucosa	NOUN
biomedich-945	16	7	;	;	PUNCT
biomedich-945	16	8	histopathology	histopathology	NOUN
biomedich-945	16	9	;	;	PUNCT
biomedich-945	16	10	mice	mouse	NOUN
biomedich-945	16	11	;	;	PUNCT
biomedich-945	16	12	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	16	13	.	.	PUNCT
biomedich-945	17	1	abbreviations	abbreviation	NOUN
biomedich-945	17	2	:	:	PUNCT
biomedich-945	17	3	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	17	4	(	(	PUNCT
biomedich-945	17	5	cfx	cfx	PROPN
biomedich-945	17	6	)	)	PUNCT
biomedich-945	17	7	;	;	PUNCT
biomedich-945	17	8	reactive	reactive	ADJ
biomedich-945	17	9	oxygen	oxygen	NOUN
biomedich-945	17	10	species	specie	NOUN
biomedich-945	17	11	(	(	PUNCT
biomedich-945	17	12	ros	ros	PROPN
biomedich-945	17	13	)	)	PUNCT
biomedich-945	17	14	;	;	PUNCT
biomedich-945	17	15	tumor	tumor	NOUN
biomedich-945	17	16	necrosis	necrosis	NOUN
biomedich-945	17	17	factor	factor	NOUN
biomedich-945	17	18	alpha	alpha	NOUN
biomedich-945	17	19	(	(	PUNCT
biomedich-945	17	20	tnf	tnf	PROPN
biomedich-945	17	21	-	-	PUNCT
biomedich-945	17	22	α	α	NOUN
biomedich-945	17	23	)	)	PUNCT
biomedich-945	17	24	;	;	PUNCT
biomedich-945	17	25	zonula	zonula	NOUN
biomedich-945	17	26	occludens-1	occludens-1	PROPN
biomedich-945	17	27	(	(	PUNCT
biomedich-945	17	28	zo-1	zo-1	NUM
biomedich-945	17	29	)	)	PUNCT
biomedich-945	17	30	;	;	PUNCT
biomedich-945	17	31	interleukin-1	interleukin-1	NUM
biomedich-945	17	32	beta	beta	NOUN
biomedich-945	17	33	(	(	PUNCT
biomedich-945	17	34	il-1β	il-1β	PROPN
biomedich-945	17	35	)	)	PUNCT
biomedich-945	17	36	;	;	PUNCT
biomedich-945	17	37	hematoxylin	hematoxylin	NOUN
biomedich-945	17	38	and	and	CCONJ
biomedich-945	17	39	eosin	eosin	PROPN
biomedich-945	17	40	(	(	PUNCT
biomedich-945	17	41	h&e	h&e	PROPN
biomedich-945	17	42	)	)	PUNCT
biomedich-945	17	43	;	;	PUNCT
biomedich-945	17	44	u.s	u.s	PROPN
biomedich-945	17	45	.	.	PROPN
biomedich-945	17	46	food	food	PROPN
biomedich-945	17	47	and	and	CCONJ
biomedich-945	17	48	drug	drug	PROPN
biomedich-945	17	49	administration	administration	PROPN
biomedich-945	17	50	(	(	PUNCT
biomedich-945	17	51	fda	fda	PROPN
biomedich-945	17	52	)	)	PUNCT
biomedich-945	17	53	;	;	PUNCT
biomedich-945	17	54	standard	standard	ADJ
biomedich-945	17	55	deviation	deviation	NOUN
biomedich-945	17	56	(	(	PUNCT
biomedich-945	17	57	sd	sd	NOUN
biomedich-945	17	58	)	)	PUNCT
biomedich-945	17	59	;	;	PUNCT
biomedich-945	17	60	analysis	analysis	NOUN
biomedich-945	17	61	of	of	ADP
biomedich-945	17	62	variance	variance	NOUN
biomedich-945	17	63	(	(	PUNCT
biomedich-945	17	64	anova	anova	PROPN
biomedich-945	17	65	)	)	PUNCT
biomedich-945	17	66	;	;	PUNCT
biomedich-945	17	67	statistical	statistical	ADJ
biomedich-945	17	68	package	package	NOUN
biomedich-945	17	69	for	for	ADP
biomedich-945	17	70	the	the	DET
biomedich-945	17	71	social	social	ADJ
biomedich-945	17	72	sciences	sciences	PROPN
biomedich-945	17	73	(	(	PUNCT
biomedich-945	17	74	spss	spss	ADJ
biomedich-945	17	75	)	)	PUNCT
biomedich-945	17	76	introduction	introduction	NOUN
biomedich-945	17	77	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	17	78	is	be	AUX
biomedich-945	17	79	a	a	DET
biomedich-945	17	80	widely	widely	ADV
biomedich-945	17	81	used	use	VERB
biomedich-945	17	82	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	17	83	antibiotic	antibiotic	ADJ
biomedich-945	17	84	,	,	PUNCT
biomedich-945	17	85	appreciated	appreciate	VERB
biomedich-945	17	86	for	for	ADP
biomedich-945	17	87	its	its	PRON
biomedich-945	17	88	broad	broad	ADJ
biomedich-945	17	89	-	-	PUNCT
biomedich-945	17	90	spectrum	spectrum	NOUN
biomedich-945	17	91	activity	activity	NOUN
biomedich-945	17	92	and	and	CCONJ
biomedich-945	17	93	favorable	favorable	ADJ
biomedich-945	17	94	pharmacokinetics	pharmacokinetic	NOUN
biomedich-945	17	95	.	.	PUNCT
biomedich-945	18	1	while	while	SCONJ
biomedich-945	18	2	its	its	PRON
biomedich-945	18	3	systemic	systemic	ADJ
biomedich-945	18	4	safety	safety	NOUN
biomedich-945	18	5	profile	profile	NOUN
biomedich-945	18	6	is	be	AUX
biomedich-945	18	7	well	well	ADV
biomedich-945	18	8	established	establish	VERB
biomedich-945	18	9	,	,	PUNCT
biomedich-945	18	10	less	less	ADJ
biomedich-945	18	11	is	be	AUX
biomedich-945	18	12	known	know	VERB
biomedich-945	18	13	about	about	ADP
biomedich-945	18	14	its	its	PRON
biomedich-945	18	15	localized	localized	ADJ
biomedich-945	18	16	effects	effect	NOUN
biomedich-945	18	17	on	on	ADP
biomedich-945	18	18	gastric	gastric	ADJ
biomedich-945	18	19	tissue	tissue	NOUN
biomedich-945	18	20	,	,	PUNCT
biomedich-945	18	21	particularly	particularly	ADV
biomedich-945	18	22	following	follow	VERB
biomedich-945	18	23	prolonged	prolonged	ADJ
biomedich-945	18	24	administration	administration	NOUN
biomedich-945	18	25	.	.	PUNCT
biomedich-945	19	1	a	a	DET
biomedich-945	19	2	recent	recent	ADJ
biomedich-945	19	3	study	study	NOUN
biomedich-945	19	4	in	in	ADP
biomedich-945	19	5	albino	albino	NOUN
biomedich-945	19	6	rats	rat	NOUN
biomedich-945	19	7	demonstrated	demonstrate	VERB
biomedich-945	19	8	that	that	SCONJ
biomedich-945	19	9	prolonged	prolong	VERB
biomedich-945	19	10	oral	oral	ADJ
biomedich-945	19	11	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	19	12	administration	administration	NOUN
biomedich-945	19	13	(	(	PUNCT
biomedich-945	19	14	12.5	12.5	NUM
biomedich-945	19	15	mg	mg	PROPN
biomedich-945	19	16	/	/	SYM
biomedich-945	19	17	kg	kg	PROPN
biomedich-945	19	18	/	/	SYM
biomedich-945	19	19	day	day	NOUN
biomedich-945	19	20	for	for	ADP
biomedich-945	19	21	60	60	NUM
biomedich-945	19	22	days	day	NOUN
biomedich-945	19	23	)	)	PUNCT
biomedich-945	19	24	led	lead	VERB
biomedich-945	19	25	to	to	ADP
biomedich-945	19	26	significant	significant	ADJ
biomedich-945	19	27	alterations	alteration	NOUN
biomedich-945	19	28	in	in	ADP
biomedich-945	19	29	gastric	gastric	ADJ
biomedich-945	19	30	mucosal	mucosal	NOUN
biomedich-945	19	31	architecture	architecture	NOUN
biomedich-945	19	32	,	,	PUNCT
biomedich-945	19	33	as	as	SCONJ
biomedich-945	19	34	observed	observe	VERB
biomedich-945	19	35	via	via	ADP
biomedich-945	19	36	immunohistochemistry	immunohistochemistry	NOUN
biomedich-945	19	37	and	and	CCONJ
biomedich-945	19	38	scanning	scan	VERB
biomedich-945	19	39	electron	electron	NOUN
biomedich-945	19	40	microscopy	microscopy	NOUN
biomedich-945	19	41	.	.	PUNCT
biomedich-945	20	1	the	the	DET
biomedich-945	20	2	study	study	NOUN
biomedich-945	20	3	also	also	ADV
biomedich-945	20	4	reported	report	VERB
biomedich-945	20	5	elevated	elevated	ADJ
biomedich-945	20	6	tnf	tnf	PROPN
biomedich-945	20	7	-	-	PUNCT
biomedich-945	20	8	α	α	NOUN
biomedich-945	20	9	expression	expression	NOUN
biomedich-945	20	10	and	and	CCONJ
biomedich-945	20	11	reduced	reduced	ADJ
biomedich-945	20	12	levels	level	NOUN
biomedich-945	20	13	of	of	ADP
biomedich-945	20	14	several	several	ADJ
biomedich-945	20	15	helicobacter	helicobacter	NOUN
biomedich-945	20	16	pylori	pylori	NOUN
biomedich-945	20	17	immunoglobulins	immunoglobulin	NOUN
biomedich-945	20	18	—	—	PUNCT
biomedich-945	20	19	suggesting	suggest	VERB
biomedich-945	20	20	mucosal	mucosal	ADJ
biomedich-945	20	21	inflammation	inflammation	NOUN
biomedich-945	20	22	and	and	CCONJ
biomedich-945	20	23	immune	immune	ADJ
biomedich-945	20	24	modulation	modulation	NOUN
biomedich-945	20	25	(	(	PUNCT
biomedich-945	20	26	elmasry	elmasry	NOUN
biomedich-945	20	27	et	et	NOUN
biomedich-945	20	28	al	al	PROPN
biomedich-945	20	29	.	.	PROPN
biomedich-945	20	30	,	,	PUNCT
biomedich-945	20	31	2021	2021	NUM
biomedich-945	20	32	)	)	PUNCT
biomedich-945	20	33	.	.	PUNCT
biomedich-945	21	1	although	although	SCONJ
biomedich-945	21	2	not	not	PART
biomedich-945	21	3	focused	focus	VERB
biomedich-945	21	4	solely	solely	ADV
biomedich-945	21	5	on	on	ADP
biomedich-945	21	6	the	the	DET
biomedich-945	21	7	stomach	stomach	NOUN
biomedich-945	21	8	,	,	PUNCT
biomedich-945	21	9	broader	broad	ADJ
biomedich-945	21	10	drug	drug	NOUN
biomedich-945	21	11	-	-	PUNCT
biomedich-945	21	12	induced	induce	VERB
biomedich-945	21	13	gastric	gastric	ADJ
biomedich-945	21	14	injury	injury	NOUN
biomedich-945	21	15	is	be	AUX
biomedich-945	21	16	clinically	clinically	ADV
biomedich-945	21	17	significant	significant	ADJ
biomedich-945	21	18	.	.	PUNCT
biomedich-945	22	1	a	a	DET
biomedich-945	22	2	2025	2025	NUM
biomedich-945	22	3	review	review	NOUN
biomedich-945	22	4	highlighted	highlight	VERB
biomedich-945	22	5	that	that	SCONJ
biomedich-945	22	6	various	various	ADJ
biomedich-945	22	7	medications	medication	NOUN
biomedich-945	22	8	—	—	PUNCT
biomedich-945	22	9	including	include	VERB
biomedich-945	22	10	antibiotics	antibiotic	NOUN
biomedich-945	22	11	—	—	PUNCT
biomedich-945	22	12	can	can	AUX
biomedich-945	22	13	cause	cause	VERB
biomedich-945	22	14	distinct	distinct	ADJ
biomedich-945	22	15	histopathological	histopathological	ADJ
biomedich-945	22	16	changes	change	NOUN
biomedich-945	22	17	in	in	ADP
biomedich-945	22	18	gastric	gastric	ADJ
biomedich-945	22	19	mucosa	mucosa	NOUN
biomedich-945	22	20	,	,	PUNCT
biomedich-945	22	21	emphasizing	emphasize	VERB
biomedich-945	22	22	the	the	DET
biomedich-945	22	23	need	need	NOUN
biomedich-945	22	24	for	for	ADP
biomedich-945	22	25	histological	histological	ADJ
biomedich-945	22	26	awareness	awareness	NOUN
biomedich-945	22	27	when	when	SCONJ
biomedich-945	22	28	evaluating	evaluate	VERB
biomedich-945	22	29	drug	drug	NOUN
biomedich-945	22	30	safety	safety	NOUN
biomedich-945	22	31	(	(	PUNCT
biomedich-945	22	32	gastroenterological	gastroenterological	ADJ
biomedich-945	22	33	endoscopy	endoscopy	NOUN
biomedich-945	22	34	society	society	NOUN
biomedich-945	22	35	,	,	PUNCT
biomedich-945	22	36	2025	2025	NUM
biomedich-945	22	37	)	)	PUNCT
biomedich-945	22	38	.	.	PUNCT
biomedich-945	23	1	meanwhile	meanwhile	ADV
biomedich-945	23	2	,	,	PUNCT
biomedich-945	23	3	in	in	ADP
biomedich-945	23	4	a	a	DET
biomedich-945	23	5	mouse	mouse	NOUN
biomedich-945	23	6	model	model	NOUN
biomedich-945	23	7	,	,	PUNCT
biomedich-945	23	8	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	23	9	—	—	PUNCT
biomedich-945	23	10	especially	especially	ADV
biomedich-945	23	11	when	when	SCONJ
biomedich-945	23	12	combined	combine	VERB
biomedich-945	23	13	with	with	ADP
biomedich-945	23	14	other	other	ADJ
biomedich-945	23	15	therapies	therapy	NOUN
biomedich-945	23	16	—	—	PUNCT
biomedich-945	23	17	has	have	AUX
biomedich-945	23	18	been	be	AUX
biomedich-945	23	19	shown	show	VERB
biomedich-945	23	20	to	to	PART
biomedich-945	23	21	affect	affect	VERB
biomedich-945	23	22	intestinal	intestinal	ADJ
biomedich-945	23	23	pathology	pathology	NOUN
biomedich-945	23	24	and	and	CCONJ
biomedich-945	23	25	the	the	DET
biomedich-945	23	26	gut	gut	NOUN
biomedich-945	23	27	microbiota	microbiota	NOUN
biomedich-945	23	28	post	post	NOUN
biomedich-945	23	29	-	-	NOUN
biomedich-945	23	30	irradiation	irradiation	NOUN
biomedich-945	23	31	,	,	PUNCT
biomedich-945	23	32	hinting	hint	VERB
biomedich-945	23	33	at	at	ADP
biomedich-945	23	34	its	its	PRON
biomedich-945	23	35	potential	potential	NOUN
biomedich-945	23	36	to	to	PART
biomedich-945	23	37	disrupt	disrupt	VERB
biomedich-945	23	38	gastrointestinal	gastrointestinal	ADJ
biomedich-945	23	39	tissue	tissue	NOUN
biomedich-945	23	40	integrity	integrity	NOUN
biomedich-945	23	41	and	and	CCONJ
biomedich-945	23	42	microbial	microbial	ADJ
biomedich-945	23	43	balance	balance	NOUN
biomedich-945	23	44	(	(	PUNCT
biomedich-945	23	45	horseman	horseman	NOUN
biomedich-945	23	46	et	et	PROPN
biomedich-945	23	47	al	al	PROPN
biomedich-945	23	48	.	.	PROPN
biomedich-945	23	49	,	,	PUNCT
biomedich-945	23	50	2024	2024	NUM
biomedich-945	23	51	)	)	PUNCT
biomedich-945	23	52	.	.	PUNCT
biomedich-945	24	1	the	the	DET
biomedich-945	24	2	widespread	widespread	ADJ
biomedich-945	24	3	use	use	NOUN
biomedich-945	24	4	of	of	ADP
biomedich-945	24	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	24	6	in	in	ADP
biomedich-945	24	7	both	both	CCONJ
biomedich-945	24	8	clinical	clinical	ADJ
biomedich-945	24	9	and	and	CCONJ
biomedich-945	24	10	veterinary	veterinary	ADJ
biomedich-945	24	11	practice	practice	NOUN
biomedich-945	24	12	makes	make	VERB
biomedich-945	24	13	it	it	PRON
biomedich-945	24	14	one	one	NUM
biomedich-945	24	15	of	of	ADP
biomedich-945	24	16	the	the	DET
biomedich-945	24	17	most	most	ADV
biomedich-945	24	18	frequently	frequently	ADV
biomedich-945	24	19	prescribed	prescribe	VERB
biomedich-945	24	20	antibiotics	antibiotic	NOUN
biomedich-945	24	21	.	.	PUNCT
biomedich-945	25	1	while	while	SCONJ
biomedich-945	25	2	its	its	PRON
biomedich-945	25	3	therapeutic	therapeutic	ADJ
biomedich-945	25	4	benefits	benefit	NOUN
biomedich-945	25	5	are	be	AUX
biomedich-945	25	6	clear	clear	ADJ
biomedich-945	25	7	,	,	PUNCT
biomedich-945	25	8	increasing	increase	VERB
biomedich-945	25	9	reports	report	NOUN
biomedich-945	25	10	of	of	ADP
biomedich-945	25	11	adverse	adverse	ADJ
biomedich-945	25	12	reactions	reaction	NOUN
biomedich-945	25	13	have	have	AUX
biomedich-945	25	14	drawn	draw	VERB
biomedich-945	25	15	attention	attention	NOUN
biomedich-945	25	16	to	to	ADP
biomedich-945	25	17	the	the	DET
biomedich-945	25	18	need	need	NOUN
biomedich-945	25	19	for	for	ADP
biomedich-945	25	20	deeper	deep	ADJ
biomedich-945	25	21	evaluation	evaluation	NOUN
biomedich-945	25	22	of	of	ADP
biomedich-945	25	23	its	its	PRON
biomedich-945	25	24	safety	safety	NOUN
biomedich-945	25	25	profile	profile	NOUN
biomedich-945	25	26	,	,	PUNCT
biomedich-945	25	27	particularly	particularly	ADV
biomedich-945	25	28	regarding	regard	VERB
biomedich-945	25	29	effects	effect	NOUN
biomedich-945	25	30	on	on	ADP
biomedich-945	25	31	the	the	DET
biomedich-945	25	32	gastrointestinal	gastrointestinal	ADJ
biomedich-945	25	33	system	system	NOUN
biomedich-945	25	34	(	(	PUNCT
biomedich-945	25	35	el	el	PROPN
biomedich-945	25	36	-	-	PROPN
biomedich-945	25	37	masry	masry	PROPN
biomedich-945	25	38	et	et	PROPN
biomedich-945	25	39	al	al	PROPN
biomedich-945	25	40	.	.	PROPN
biomedich-945	25	41	,	,	PUNCT
biomedich-945	25	42	2021	2021	NUM
biomedich-945	25	43	)	)	PUNCT
biomedich-945	25	44	.	.	PUNCT
biomedich-945	26	1	among	among	ADP
biomedich-945	26	2	https://doi.org/10.14421/biomedich.2025.142.873-878	https://doi.org/10.14421/biomedich.2025.142.873-878	X
biomedich-945	26	3	mailto:lisasavitri@unik-kediri.ac.id	mailto:lisasavitri@unik-kediri.ac.id	NOUN
biomedich-945	26	4	874	874	NUM
biomedich-945	26	5	biology	biology	NOUN
biomedich-945	26	6	,	,	PUNCT
biomedich-945	26	7	medicine	medicine	NOUN
biomedich-945	26	8	,	,	PUNCT
biomedich-945	26	9	&	&	CCONJ
biomedich-945	26	10	natural	natural	ADJ
biomedich-945	26	11	product	product	NOUN
biomedich-945	26	12	chemistry	chemistry	NOUN
biomedich-945	26	13	14	14	NUM
biomedich-945	26	14	(	(	PUNCT
biomedich-945	26	15	2	2	NUM
biomedich-945	26	16	)	)	PUNCT
biomedich-945	26	17	,	,	PUNCT
biomedich-945	26	18	2025	2025	NUM
biomedich-945	26	19	:	:	PUNCT
biomedich-945	26	20	873	873	NUM
biomedich-945	26	21	-	-	SYM
biomedich-945	26	22	878	878	NUM
biomedich-945	26	23	the	the	DET
biomedich-945	26	24	organs	organ	NOUN
biomedich-945	26	25	potentially	potentially	ADV
biomedich-945	26	26	affected	affect	VERB
biomedich-945	26	27	,	,	PUNCT
biomedich-945	26	28	the	the	DET
biomedich-945	26	29	stomach	stomach	NOUN
biomedich-945	26	30	plays	play	VERB
biomedich-945	26	31	a	a	DET
biomedich-945	26	32	central	central	ADJ
biomedich-945	26	33	role	role	NOUN
biomedich-945	26	34	not	not	PART
biomedich-945	26	35	only	only	ADV
biomedich-945	26	36	in	in	ADP
biomedich-945	26	37	digestion	digestion	NOUN
biomedich-945	26	38	but	but	CCONJ
biomedich-945	26	39	also	also	ADV
biomedich-945	26	40	as	as	ADP
biomedich-945	26	41	a	a	DET
biomedich-945	26	42	protective	protective	ADJ
biomedich-945	26	43	barrier	barrier	NOUN
biomedich-945	26	44	against	against	ADP
biomedich-945	26	45	pathogens	pathogen	NOUN
biomedich-945	26	46	and	and	CCONJ
biomedich-945	26	47	chemical	chemical	NOUN
biomedich-945	26	48	insults	insult	NOUN
biomedich-945	26	49	.	.	PUNCT
biomedich-945	27	1	any	any	DET
biomedich-945	27	2	alteration	alteration	NOUN
biomedich-945	27	3	to	to	ADP
biomedich-945	27	4	gastric	gastric	ADJ
biomedich-945	27	5	mucosal	mucosal	NOUN
biomedich-945	27	6	integrity	integrity	NOUN
biomedich-945	27	7	may	may	AUX
biomedich-945	27	8	therefore	therefore	ADV
biomedich-945	27	9	have	have	VERB
biomedich-945	27	10	far	far	ADV
biomedich-945	27	11	-	-	PUNCT
biomedich-945	27	12	reaching	reach	VERB
biomedich-945	27	13	implications	implication	NOUN
biomedich-945	27	14	for	for	ADP
biomedich-945	27	15	overall	overall	ADJ
biomedich-945	27	16	gastrointestinal	gastrointestinal	ADJ
biomedich-945	27	17	health	health	NOUN
biomedich-945	27	18	.	.	PUNCT
biomedich-945	28	1	drug	drug	NOUN
biomedich-945	28	2	-	-	PUNCT
biomedich-945	28	3	induced	induce	VERB
biomedich-945	28	4	gastric	gastric	ADJ
biomedich-945	28	5	injury	injury	NOUN
biomedich-945	28	6	remains	remain	VERB
biomedich-945	28	7	a	a	DET
biomedich-945	28	8	clinically	clinically	ADV
biomedich-945	28	9	relevant	relevant	ADJ
biomedich-945	28	10	concern	concern	NOUN
biomedich-945	28	11	.	.	PUNCT
biomedich-945	29	1	recent	recent	ADJ
biomedich-945	29	2	findings	finding	NOUN
biomedich-945	29	3	emphasize	emphasize	VERB
biomedich-945	29	4	that	that	SCONJ
biomedich-945	29	5	antibiotics	antibiotic	NOUN
biomedich-945	29	6	and	and	CCONJ
biomedich-945	29	7	other	other	ADJ
biomedich-945	29	8	commonly	commonly	ADV
biomedich-945	29	9	prescribed	prescribe	VERB
biomedich-945	29	10	medications	medication	NOUN
biomedich-945	29	11	can	can	AUX
biomedich-945	29	12	lead	lead	VERB
biomedich-945	29	13	to	to	ADP
biomedich-945	29	14	characteristic	characteristic	ADJ
biomedich-945	29	15	mucosal	mucosal	NOUN
biomedich-945	29	16	changes	change	NOUN
biomedich-945	29	17	,	,	PUNCT
biomedich-945	29	18	such	such	ADJ
biomedich-945	29	19	as	as	ADP
biomedich-945	29	20	erosion	erosion	NOUN
biomedich-945	29	21	,	,	PUNCT
biomedich-945	29	22	ulceration	ulceration	NOUN
biomedich-945	29	23	,	,	PUNCT
biomedich-945	29	24	and	and	CCONJ
biomedich-945	29	25	inflammatory	inflammatory	ADJ
biomedich-945	29	26	infiltration	infiltration	NOUN
biomedich-945	29	27	(	(	PUNCT
biomedich-945	29	28	gastroenterological	gastroenterological	ADJ
biomedich-945	29	29	endoscopy	endoscopy	NOUN
biomedich-945	29	30	society	society	NOUN
biomedich-945	29	31	,	,	PUNCT
biomedich-945	29	32	2025	2025	NUM
biomedich-945	29	33	)	)	PUNCT
biomedich-945	29	34	.	.	PUNCT
biomedich-945	30	1	however	however	ADV
biomedich-945	30	2	,	,	PUNCT
biomedich-945	30	3	experimental	experimental	ADJ
biomedich-945	30	4	data	datum	NOUN
biomedich-945	30	5	linking	link	VERB
biomedich-945	30	6	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	30	7	directly	directly	ADV
biomedich-945	30	8	to	to	ADP
biomedich-945	30	9	gastric	gastric	ADJ
biomedich-945	30	10	histopathology	histopathology	NOUN
biomedich-945	30	11	remain	remain	VERB
biomedich-945	30	12	limited	limited	ADJ
biomedich-945	30	13	.	.	PUNCT
biomedich-945	31	1	most	most	ADJ
biomedich-945	31	2	research	research	NOUN
biomedich-945	31	3	to	to	ADP
biomedich-945	31	4	date	date	NOUN
biomedich-945	31	5	has	have	AUX
biomedich-945	31	6	focused	focus	VERB
biomedich-945	31	7	on	on	ADP
biomedich-945	31	8	intestinal	intestinal	ADJ
biomedich-945	31	9	microbiota	microbiota	NOUN
biomedich-945	31	10	or	or	CCONJ
biomedich-945	31	11	systemic	systemic	ADJ
biomedich-945	31	12	toxicity	toxicity	NOUN
biomedich-945	31	13	rather	rather	ADV
biomedich-945	31	14	than	than	ADP
biomedich-945	31	15	localized	localized	ADJ
biomedich-945	31	16	gastric	gastric	ADJ
biomedich-945	31	17	effects	effect	NOUN
biomedich-945	31	18	(	(	PUNCT
biomedich-945	31	19	horseman	horseman	NOUN
biomedich-945	31	20	et	et	PROPN
biomedich-945	31	21	al	al	PROPN
biomedich-945	31	22	.	.	PROPN
biomedich-945	31	23	,	,	PUNCT
biomedich-945	31	24	2024	2024	NUM
biomedich-945	31	25	)	)	PUNCT
biomedich-945	31	26	.	.	PUNCT
biomedich-945	32	1	this	this	PRON
biomedich-945	32	2	creates	create	VERB
biomedich-945	32	3	a	a	DET
biomedich-945	32	4	significant	significant	ADJ
biomedich-945	32	5	knowledge	knowledge	NOUN
biomedich-945	32	6	gap	gap	NOUN
biomedich-945	32	7	,	,	PUNCT
biomedich-945	32	8	especially	especially	ADV
biomedich-945	32	9	considering	consider	VERB
biomedich-945	32	10	that	that	SCONJ
biomedich-945	32	11	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	32	12	is	be	AUX
biomedich-945	32	13	often	often	ADV
biomedich-945	32	14	administered	administer	VERB
biomedich-945	32	15	over	over	ADP
biomedich-945	32	16	long	long	ADJ
biomedich-945	32	17	treatment	treatment	NOUN
biomedich-945	32	18	courses	course	NOUN
biomedich-945	32	19	or	or	CCONJ
biomedich-945	32	20	in	in	ADP
biomedich-945	32	21	combination	combination	NOUN
biomedich-945	32	22	with	with	ADP
biomedich-945	32	23	other	other	ADJ
biomedich-945	32	24	drugs	drug	NOUN
biomedich-945	32	25	that	that	PRON
biomedich-945	32	26	may	may	AUX
biomedich-945	32	27	amplify	amplify	VERB
biomedich-945	32	28	mucosal	mucosal	ADJ
biomedich-945	32	29	damage	damage	NOUN
biomedich-945	32	30	.	.	PUNCT
biomedich-945	33	1	evaluating	evaluate	VERB
biomedich-945	33	2	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	33	3	’s	’s	PART
biomedich-945	33	4	impact	impact	NOUN
biomedich-945	33	5	in	in	ADP
biomedich-945	33	6	mice	mouse	NOUN
biomedich-945	33	7	(	(	PUNCT
biomedich-945	33	8	mus	mus	PROPN
biomedich-945	33	9	musculus	musculus	PROPN
biomedich-945	33	10	)	)	PUNCT
biomedich-945	33	11	is	be	AUX
biomedich-945	33	12	particularly	particularly	ADV
biomedich-945	33	13	relevant	relevant	ADJ
biomedich-945	33	14	.	.	PUNCT
biomedich-945	34	1	mice	mouse	NOUN
biomedich-945	34	2	are	be	AUX
biomedich-945	34	3	widely	widely	ADV
biomedich-945	34	4	used	use	VERB
biomedich-945	34	5	in	in	ADP
biomedich-945	34	6	biomedical	biomedical	ADJ
biomedich-945	34	7	research	research	NOUN
biomedich-945	34	8	due	due	ADP
biomedich-945	34	9	to	to	ADP
biomedich-945	34	10	their	their	PRON
biomedich-945	34	11	genetic	genetic	ADJ
biomedich-945	34	12	similarity	similarity	NOUN
biomedich-945	34	13	to	to	ADP
biomedich-945	34	14	humans	human	NOUN
biomedich-945	34	15	,	,	PUNCT
biomedich-945	34	16	cost	cost	NOUN
biomedich-945	34	17	-	-	PUNCT
biomedich-945	34	18	effectiveness	effectiveness	NOUN
biomedich-945	34	19	,	,	PUNCT
biomedich-945	34	20	and	and	CCONJ
biomedich-945	34	21	well	well	ADV
biomedich-945	34	22	-	-	PUNCT
biomedich-945	34	23	characterized	characterize	VERB
biomedich-945	34	24	physiology	physiology	NOUN
biomedich-945	34	25	.	.	PUNCT
biomedich-945	35	1	studying	study	VERB
biomedich-945	35	2	gastric	gastric	ADJ
biomedich-945	35	3	histopathological	histopathological	ADJ
biomedich-945	35	4	changes	change	NOUN
biomedich-945	35	5	in	in	ADP
biomedich-945	35	6	this	this	DET
biomedich-945	35	7	model	model	NOUN
biomedich-945	35	8	allows	allow	VERB
biomedich-945	35	9	for	for	ADP
biomedich-945	35	10	detailed	detailed	ADJ
biomedich-945	35	11	analysis	analysis	NOUN
biomedich-945	35	12	of	of	ADP
biomedich-945	35	13	subtle	subtle	ADJ
biomedich-945	35	14	alterations	alteration	NOUN
biomedich-945	35	15	—	—	PUNCT
biomedich-945	35	16	such	such	ADJ
biomedich-945	35	17	as	as	ADP
biomedich-945	35	18	epithelial	epithelial	ADJ
biomedich-945	35	19	disruption	disruption	NOUN
biomedich-945	35	20	,	,	PUNCT
biomedich-945	35	21	inflammatory	inflammatory	ADJ
biomedich-945	35	22	cell	cell	NOUN
biomedich-945	35	23	infiltration	infiltration	NOUN
biomedich-945	35	24	,	,	PUNCT
biomedich-945	35	25	or	or	CCONJ
biomedich-945	35	26	mucosal	mucosal	NOUN
biomedich-945	35	27	thinning	thinning	NOUN
biomedich-945	35	28	—	—	PUNCT
biomedich-945	35	29	that	that	PRON
biomedich-945	35	30	may	may	AUX
biomedich-945	35	31	not	not	PART
biomedich-945	35	32	be	be	AUX
biomedich-945	35	33	evident	evident	ADJ
biomedich-945	35	34	in	in	ADP
biomedich-945	35	35	clinical	clinical	ADJ
biomedich-945	35	36	observations	observation	NOUN
biomedich-945	35	37	alone	alone	ADV
biomedich-945	35	38	.	.	PUNCT
biomedich-945	36	1	such	such	ADJ
biomedich-945	36	2	insights	insight	NOUN
biomedich-945	36	3	can	can	AUX
biomedich-945	36	4	bridge	bridge	VERB
biomedich-945	36	5	preclinical	preclinical	ADJ
biomedich-945	36	6	findings	finding	NOUN
biomedich-945	36	7	with	with	ADP
biomedich-945	36	8	human	human	ADJ
biomedich-945	36	9	outcomes	outcome	NOUN
biomedich-945	36	10	,	,	PUNCT
biomedich-945	36	11	contributing	contribute	VERB
biomedich-945	36	12	to	to	ADP
biomedich-945	36	13	a	a	DET
biomedich-945	36	14	more	more	ADV
biomedich-945	36	15	comprehensive	comprehensive	ADJ
biomedich-945	36	16	understanding	understanding	NOUN
biomedich-945	36	17	of	of	ADP
biomedich-945	36	18	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	36	19	’s	’s	PART
biomedich-945	36	20	gastrointestinal	gastrointestinal	ADJ
biomedich-945	36	21	safety	safety	NOUN
biomedich-945	36	22	.	.	PUNCT
biomedich-945	37	1	another	another	DET
biomedich-945	37	2	dimension	dimension	NOUN
biomedich-945	37	3	of	of	ADP
biomedich-945	37	4	urgency	urgency	NOUN
biomedich-945	37	5	relates	relate	VERB
biomedich-945	37	6	to	to	ADP
biomedich-945	37	7	the	the	DET
biomedich-945	37	8	broader	broad	ADJ
biomedich-945	37	9	issue	issue	NOUN
biomedich-945	37	10	of	of	ADP
biomedich-945	37	11	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	37	12	safety	safety	NOUN
biomedich-945	37	13	.	.	PUNCT
biomedich-945	38	1	beyond	beyond	ADP
biomedich-945	38	2	contributing	contribute	VERB
biomedich-945	38	3	to	to	ADP
biomedich-945	38	4	antimicrobial	antimicrobial	ADJ
biomedich-945	38	5	resistance	resistance	NOUN
biomedich-945	38	6	,	,	PUNCT
biomedich-945	38	7	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	38	8	have	have	AUX
biomedich-945	38	9	been	be	AUX
biomedich-945	38	10	associated	associate	VERB
biomedich-945	38	11	with	with	ADP
biomedich-945	38	12	serious	serious	ADJ
biomedich-945	38	13	adverse	adverse	ADJ
biomedich-945	38	14	effects	effect	NOUN
biomedich-945	38	15	,	,	PUNCT
biomedich-945	38	16	including	include	VERB
biomedich-945	38	17	tendon	tendon	NOUN
biomedich-945	38	18	rupture	rupture	NOUN
biomedich-945	38	19	,	,	PUNCT
biomedich-945	38	20	neurotoxicity	neurotoxicity	NOUN
biomedich-945	38	21	,	,	PUNCT
biomedich-945	38	22	and	and	CCONJ
biomedich-945	38	23	cardiotoxicity	cardiotoxicity	PROPN
biomedich-945	38	24	,	,	PUNCT
biomedich-945	38	25	resulting	result	VERB
biomedich-945	38	26	in	in	ADP
biomedich-945	38	27	multiple	multiple	ADJ
biomedich-945	38	28	fda	fda	PROPN
biomedich-945	38	29	safety	safety	PROPN
biomedich-945	38	30	communications	communication	NOUN
biomedich-945	38	31	(	(	PUNCT
biomedich-945	38	32	u.s	u.s	PROPN
biomedich-945	38	33	.	.	PROPN
biomedich-945	38	34	food	food	PROPN
biomedich-945	38	35	and	and	CCONJ
biomedich-945	38	36	drug	drug	NOUN
biomedich-945	38	37	administration	administration	NOUN
biomedich-945	38	38	,	,	PUNCT
biomedich-945	38	39	2018	2018	NUM
biomedich-945	38	40	)	)	PUNCT
biomedich-945	38	41	.	.	PUNCT
biomedich-945	39	1	if	if	SCONJ
biomedich-945	39	2	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	39	3	also	also	ADV
biomedich-945	39	4	contributes	contribute	VERB
biomedich-945	39	5	to	to	ADP
biomedich-945	39	6	gastric	gastric	ADJ
biomedich-945	39	7	mucosal	mucosal	NOUN
biomedich-945	39	8	injury	injury	NOUN
biomedich-945	39	9	,	,	PUNCT
biomedich-945	39	10	the	the	DET
biomedich-945	39	11	risk	risk	NOUN
biomedich-945	39	12	–	–	PUNCT
biomedich-945	39	13	benefit	benefit	NOUN
biomedich-945	39	14	balance	balance	NOUN
biomedich-945	39	15	must	must	AUX
biomedich-945	39	16	be	be	AUX
biomedich-945	39	17	reconsidered	reconsider	VERB
biomedich-945	39	18	,	,	PUNCT
biomedich-945	39	19	particularly	particularly	ADV
biomedich-945	39	20	in	in	ADP
biomedich-945	39	21	patients	patient	NOUN
biomedich-945	39	22	with	with	ADP
biomedich-945	39	23	pre	pre	ADJ
biomedich-945	39	24	-	-	ADJ
biomedich-945	39	25	existing	exist	VERB
biomedich-945	39	26	gastrointestinal	gastrointestinal	ADJ
biomedich-945	39	27	disorders	disorder	NOUN
biomedich-945	39	28	.	.	PUNCT
biomedich-945	40	1	taken	take	VERB
biomedich-945	40	2	together	together	ADV
biomedich-945	40	3	,	,	PUNCT
biomedich-945	40	4	the	the	DET
biomedich-945	40	5	investigation	investigation	NOUN
biomedich-945	40	6	of	of	ADP
biomedich-945	40	7	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	40	8	’s	’s	PART
biomedich-945	40	9	effects	effect	NOUN
biomedich-945	40	10	on	on	ADP
biomedich-945	40	11	gastric	gastric	ADJ
biomedich-945	40	12	histopathology	histopathology	NOUN
biomedich-945	40	13	in	in	ADP
biomedich-945	40	14	mice	mice	NOUN
biomedich-945	40	15	is	be	AUX
biomedich-945	40	16	both	both	PRON
biomedich-945	40	17	scientifically	scientifically	ADV
biomedich-945	40	18	relevant	relevant	ADJ
biomedich-945	40	19	and	and	CCONJ
biomedich-945	40	20	clinically	clinically	ADV
biomedich-945	40	21	significant	significant	ADJ
biomedich-945	40	22	.	.	PUNCT
biomedich-945	41	1	it	it	PRON
biomedich-945	41	2	will	will	AUX
biomedich-945	41	3	provide	provide	VERB
biomedich-945	41	4	new	new	ADJ
biomedich-945	41	5	insights	insight	NOUN
biomedich-945	41	6	into	into	ADP
biomedich-945	41	7	the	the	DET
biomedich-945	41	8	safety	safety	NOUN
biomedich-945	41	9	of	of	ADP
biomedich-945	41	10	a	a	DET
biomedich-945	41	11	widely	widely	ADV
biomedich-945	41	12	used	use	VERB
biomedich-945	41	13	antibiotic	antibiotic	NOUN
biomedich-945	41	14	,	,	PUNCT
biomedich-945	41	15	inform	inform	VERB
biomedich-945	41	16	rational	rational	ADJ
biomedich-945	41	17	prescribing	prescribing	NOUN
biomedich-945	41	18	practices	practice	NOUN
biomedich-945	41	19	,	,	PUNCT
biomedich-945	41	20	and	and	CCONJ
biomedich-945	41	21	support	support	VERB
biomedich-945	41	22	preventive	preventive	ADJ
biomedich-945	41	23	strategies	strategy	NOUN
biomedich-945	41	24	to	to	PART
biomedich-945	41	25	minimize	minimize	VERB
biomedich-945	41	26	drug	drug	NOUN
biomedich-945	41	27	-	-	PUNCT
biomedich-945	41	28	induced	induce	VERB
biomedich-945	41	29	gastric	gastric	ADJ
biomedich-945	41	30	injury	injury	NOUN
biomedich-945	41	31	.	.	PUNCT
biomedich-945	42	1	materials	material	NOUN
biomedich-945	42	2	and	and	CCONJ
biomedich-945	42	3	methods	method	NOUN
biomedich-945	42	4	research	research	NOUN
biomedich-945	42	5	design	design	NOUN
biomedich-945	42	6	this	this	DET
biomedich-945	42	7	study	study	NOUN
biomedich-945	42	8	employed	employ	VERB
biomedich-945	42	9	an	an	DET
biomedich-945	42	10	experimental	experimental	ADJ
biomedich-945	42	11	laboratory	laboratory	NOUN
biomedich-945	42	12	design	design	NOUN
biomedich-945	42	13	with	with	ADP
biomedich-945	42	14	a	a	DET
biomedich-945	42	15	post	post	ADJ
biomedich-945	42	16	-	-	ADJ
biomedich-945	42	17	test	test	ADJ
biomedich-945	42	18	only	only	ADV
biomedich-945	42	19	control	control	NOUN
biomedich-945	42	20	group	group	NOUN
biomedich-945	42	21	approach	approach	NOUN
biomedich-945	42	22	.	.	PUNCT
biomedich-945	43	1	the	the	DET
biomedich-945	43	2	aim	aim	NOUN
biomedich-945	43	3	was	be	AUX
biomedich-945	43	4	to	to	PART
biomedich-945	43	5	compare	compare	VERB
biomedich-945	43	6	gastric	gastric	ADJ
biomedich-945	43	7	histopathological	histopathological	ADJ
biomedich-945	43	8	features	feature	NOUN
biomedich-945	43	9	in	in	ADP
biomedich-945	43	10	mice	mouse	NOUN
biomedich-945	43	11	receiving	receive	VERB
biomedich-945	43	12	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	43	13	administration	administration	NOUN
biomedich-945	43	14	with	with	ADP
biomedich-945	43	15	those	those	PRON
biomedich-945	43	16	of	of	ADP
biomedich-945	43	17	untreated	untreated	ADJ
biomedich-945	43	18	controls	control	NOUN
biomedich-945	43	19	.	.	PUNCT
biomedich-945	44	1	experimental	experimental	ADJ
biomedich-945	44	2	animals	animal	NOUN
biomedich-945	44	3	a	a	DET
biomedich-945	44	4	total	total	NOUN
biomedich-945	44	5	of	of	ADP
biomedich-945	44	6	24	24	NUM
biomedich-945	44	7	healthy	healthy	ADJ
biomedich-945	44	8	male	male	ADJ
biomedich-945	44	9	mice	mouse	NOUN
biomedich-945	44	10	(	(	PUNCT
biomedich-945	44	11	mus	mus	PROPN
biomedich-945	44	12	musculus	musculus	PROPN
biomedich-945	44	13	)	)	PUNCT
biomedich-945	44	14	,	,	PUNCT
biomedich-945	44	15	aged	aged	ADJ
biomedich-945	44	16	8	8	NUM
biomedich-945	44	17	–	–	SYM
biomedich-945	44	18	10	10	NUM
biomedich-945	44	19	weeks	week	NOUN
biomedich-945	44	20	and	and	CCONJ
biomedich-945	44	21	weighing	weigh	VERB
biomedich-945	44	22	25–30	25–30	NUM
biomedich-945	44	23	g	g	NOUN
biomedich-945	44	24	,	,	PUNCT
biomedich-945	44	25	were	be	AUX
biomedich-945	44	26	obtained	obtain	VERB
biomedich-945	44	27	from	from	ADP
biomedich-945	44	28	an	an	DET
biomedich-945	44	29	accredited	accredit	VERB
biomedich-945	44	30	animal	animal	NOUN
biomedich-945	44	31	breeding	breeding	NOUN
biomedich-945	44	32	facility	facility	NOUN
biomedich-945	44	33	.	.	PUNCT
biomedich-945	45	1	all	all	DET
biomedich-945	45	2	animals	animal	NOUN
biomedich-945	45	3	were	be	AUX
biomedich-945	45	4	acclimatized	acclimatize	VERB
biomedich-945	45	5	for	for	ADP
biomedich-945	45	6	one	one	NUM
biomedich-945	45	7	week	week	NOUN
biomedich-945	45	8	under	under	ADP
biomedich-945	45	9	standard	standard	ADJ
biomedich-945	45	10	laboratory	laboratory	NOUN
biomedich-945	45	11	conditions	condition	NOUN
biomedich-945	45	12	(	(	PUNCT
biomedich-945	45	13	12	12	NUM
biomedich-945	45	14	-	-	PUNCT
biomedich-945	45	15	hour	hour	NOUN
biomedich-945	45	16	light	light	ADJ
biomedich-945	45	17	/	/	SYM
biomedich-945	45	18	dark	dark	ADJ
biomedich-945	45	19	cycle	cycle	NOUN
biomedich-945	45	20	,	,	PUNCT
biomedich-945	45	21	room	room	NOUN
biomedich-945	45	22	temperature	temperature	NOUN
biomedich-945	45	23	22–25	22–25	NUM
biomedich-945	46	1	°	°	NOUN
biomedich-945	46	2	c	c	NOUN
biomedich-945	46	3	,	,	PUNCT
biomedich-945	46	4	relative	relative	ADJ
biomedich-945	46	5	humidity	humidity	NOUN
biomedich-945	46	6	50–60	50–60	NUM
biomedich-945	46	7	%	%	NOUN
biomedich-945	46	8	)	)	PUNCT
biomedich-945	46	9	,	,	PUNCT
biomedich-945	46	10	with	with	ADP
biomedich-945	46	11	free	free	ADJ
biomedich-945	46	12	access	access	NOUN
biomedich-945	46	13	to	to	ADP
biomedich-945	46	14	standard	standard	ADJ
biomedich-945	46	15	pellet	pellet	NOUN
biomedich-945	46	16	diet	diet	NOUN
biomedich-945	46	17	and	and	CCONJ
biomedich-945	46	18	water	water	NOUN
biomedich-945	46	19	ad	ad	NOUN
biomedich-945	46	20	libitum	libitum	PROPN
biomedich-945	46	21	.	.	PUNCT
biomedich-945	47	1	grouping	grouping	NOUN
biomedich-945	47	2	and	and	CCONJ
biomedich-945	47	3	treatment	treatment	NOUN
biomedich-945	47	4	mice	mouse	NOUN
biomedich-945	47	5	were	be	AUX
biomedich-945	47	6	randomly	randomly	ADV
biomedich-945	47	7	divided	divide	VERB
biomedich-945	47	8	into	into	ADP
biomedich-945	47	9	four	four	NUM
biomedich-945	47	10	groups	group	NOUN
biomedich-945	47	11	(	(	PUNCT
biomedich-945	47	12	n	n	NOUN
biomedich-945	47	13	=	=	SYM
biomedich-945	47	14	6	6	NUM
biomedich-945	47	15	per	per	ADP
biomedich-945	47	16	group	group	NOUN
biomedich-945	47	17	):	):	PUNCT
biomedich-945	47	18	a.	a.	NOUN
biomedich-945	47	19	group	group	NOUN
biomedich-945	47	20	i	i	PRON
biomedich-945	47	21	(	(	PUNCT
biomedich-945	47	22	control	control	PROPN
biomedich-945	47	23	):	):	PUNCT
biomedich-945	47	24	received	receive	VERB
biomedich-945	47	25	distilled	distil	VERB
biomedich-945	47	26	water	water	NOUN
biomedich-945	47	27	orally	orally	ADV
biomedich-945	47	28	.	.	PUNCT
biomedich-945	48	1	b.	b.	PROPN
biomedich-945	48	2	group	group	PROPN
biomedich-945	48	3	ii	ii	PROPN
biomedich-945	48	4	(	(	PUNCT
biomedich-945	48	5	low	low	ADJ
biomedich-945	48	6	-	-	PUNCT
biomedich-945	48	7	dose	dose	NOUN
biomedich-945	48	8	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	48	9	):	):	PUNCT
biomedich-945	48	10	received	receive	VERB
biomedich-945	48	11	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	48	12	10	10	NUM
biomedich-945	48	13	mg	mg	NUM
biomedich-945	48	14	/	/	SYM
biomedich-945	48	15	kg	kg	PROPN
biomedich-945	48	16	/	/	SYM
biomedich-945	48	17	day	day	NOUN
biomedich-945	48	18	orally	orally	ADV
biomedich-945	48	19	.	.	PUNCT
biomedich-945	49	1	c.	c.	PROPN
biomedich-945	49	2	group	group	PROPN
biomedich-945	49	3	iii	iii	PROPN
biomedich-945	49	4	(	(	PUNCT
biomedich-945	49	5	moderate	moderate	ADJ
biomedich-945	49	6	-	-	PUNCT
biomedich-945	49	7	dose	dose	NOUN
biomedich-945	49	8	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	49	9	):	):	PUNCT
biomedich-945	49	10	received	receive	VERB
biomedich-945	49	11	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	49	12	20	20	NUM
biomedich-945	49	13	mg	mg	NUM
biomedich-945	49	14	/	/	SYM
biomedich-945	49	15	kg	kg	PROPN
biomedich-945	49	16	/	/	SYM
biomedich-945	49	17	day	day	NOUN
biomedich-945	49	18	orally	orally	ADV
biomedich-945	49	19	.	.	PUNCT
biomedich-945	50	1	d.	d.	PROPN
biomedich-945	50	2	group	group	PROPN
biomedich-945	50	3	iv	iv	PROPN
biomedich-945	50	4	(	(	PUNCT
biomedich-945	50	5	high	high	ADJ
biomedich-945	50	6	-	-	PUNCT
biomedich-945	50	7	dose	dose	NOUN
biomedich-945	50	8	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	50	9	):	):	PUNCT
biomedich-945	50	10	received	receive	VERB
biomedich-945	50	11	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	50	12	40	40	NUM
biomedich-945	50	13	mg	mg	NUM
biomedich-945	50	14	/	/	SYM
biomedich-945	50	15	kg	kg	PROPN
biomedich-945	50	16	/	/	SYM
biomedich-945	50	17	day	day	NOUN
biomedich-945	50	18	orally	orally	ADV
biomedich-945	50	19	.	.	PUNCT
biomedich-945	51	1	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	51	2	doses	dose	NOUN
biomedich-945	51	3	were	be	AUX
biomedich-945	51	4	adapted	adapt	VERB
biomedich-945	51	5	from	from	ADP
biomedich-945	51	6	previous	previous	ADJ
biomedich-945	51	7	experimental	experimental	ADJ
biomedich-945	51	8	studies	study	NOUN
biomedich-945	51	9	with	with	ADP
biomedich-945	51	10	modifications	modification	NOUN
biomedich-945	51	11	to	to	PART
biomedich-945	51	12	reflect	reflect	VERB
biomedich-945	51	13	clinically	clinically	ADV
biomedich-945	51	14	relevant	relevant	ADJ
biomedich-945	51	15	ranges	range	NOUN
biomedich-945	51	16	(	(	PUNCT
biomedich-945	51	17	el	el	PROPN
biomedich-945	51	18	-	-	PUNCT
biomedich-945	51	19	masry	masry	PROPN
biomedich-945	51	20	et	et	PROPN
biomedich-945	51	21	al	al	PROPN
biomedich-945	51	22	.	.	PROPN
biomedich-945	51	23	,	,	PUNCT
biomedich-945	51	24	2021	2021	NUM
biomedich-945	51	25	;	;	PUNCT
biomedich-945	51	26	horseman	horseman	NOUN
biomedich-945	51	27	et	et	PROPN
biomedich-945	51	28	al	al	PROPN
biomedich-945	51	29	.	.	PROPN
biomedich-945	51	30	,	,	PUNCT
biomedich-945	51	31	2024	2024	NUM
biomedich-945	51	32	)	)	PUNCT
biomedich-945	51	33	.	.	PUNCT
biomedich-945	52	1	the	the	DET
biomedich-945	52	2	treatment	treatment	NOUN
biomedich-945	52	3	was	be	AUX
biomedich-945	52	4	administered	administer	VERB
biomedich-945	52	5	once	once	ADV
biomedich-945	52	6	daily	daily	ADV
biomedich-945	52	7	via	via	ADP
biomedich-945	52	8	oral	oral	ADJ
biomedich-945	52	9	gavage	gavage	NOUN
biomedich-945	52	10	for	for	ADP
biomedich-945	52	11	14	14	NUM
biomedich-945	52	12	consecutive	consecutive	ADJ
biomedich-945	52	13	days	day	NOUN
biomedich-945	52	14	.	.	PUNCT
biomedich-945	53	1	ethical	ethical	ADJ
biomedich-945	53	2	approval	approval	NOUN
biomedich-945	53	3	all	all	DET
biomedich-945	53	4	experimental	experimental	ADJ
biomedich-945	53	5	protocols	protocol	NOUN
biomedich-945	53	6	were	be	AUX
biomedich-945	53	7	reviewed	review	VERB
biomedich-945	53	8	and	and	CCONJ
biomedich-945	53	9	approved	approve	VERB
biomedich-945	53	10	by	by	ADP
biomedich-945	53	11	the	the	DET
biomedich-945	53	12	institutional	institutional	ADJ
biomedich-945	53	13	animal	animal	NOUN
biomedich-945	53	14	ethics	ethic	NOUN
biomedich-945	53	15	committee	committee	NOUN
biomedich-945	53	16	.	.	PUNCT
biomedich-945	54	1	animal	animal	NOUN
biomedich-945	54	2	handling	handling	NOUN
biomedich-945	54	3	followed	follow	VERB
biomedich-945	54	4	the	the	DET
biomedich-945	54	5	international	international	ADJ
biomedich-945	54	6	guidelines	guideline	NOUN
biomedich-945	54	7	for	for	ADP
biomedich-945	54	8	the	the	DET
biomedich-945	54	9	care	care	NOUN
biomedich-945	54	10	and	and	CCONJ
biomedich-945	54	11	use	use	NOUN
biomedich-945	54	12	of	of	ADP
biomedich-945	54	13	laboratory	laboratory	NOUN
biomedich-945	54	14	animals	animal	NOUN
biomedich-945	54	15	(	(	PUNCT
biomedich-945	54	16	nih	nih	PROPN
biomedich-945	54	17	publication	publication	PROPN
biomedich-945	54	18	no	no	PROPN
biomedich-945	54	19	.	.	PROPN
biomedich-945	54	20	85	85	NUM
biomedich-945	54	21	-	-	SYM
biomedich-945	54	22	23	23	NUM
biomedich-945	54	23	,	,	PUNCT
biomedich-945	54	24	revised	revise	VERB
biomedich-945	54	25	2011	2011	NUM
biomedich-945	54	26	)	)	PUNCT
biomedich-945	54	27	.	.	PUNCT
biomedich-945	55	1	tissue	tissue	NOUN
biomedich-945	55	2	collection	collection	NOUN
biomedich-945	55	3	at	at	ADP
biomedich-945	55	4	the	the	DET
biomedich-945	55	5	end	end	NOUN
biomedich-945	55	6	of	of	ADP
biomedich-945	55	7	the	the	DET
biomedich-945	55	8	treatment	treatment	NOUN
biomedich-945	55	9	period	period	NOUN
biomedich-945	55	10	,	,	PUNCT
biomedich-945	55	11	animals	animal	NOUN
biomedich-945	55	12	were	be	AUX
biomedich-945	55	13	fasted	fast	VERB
biomedich-945	55	14	overnight	overnight	ADV
biomedich-945	55	15	and	and	CCONJ
biomedich-945	55	16	sacrificed	sacrifice	VERB
biomedich-945	55	17	under	under	ADP
biomedich-945	55	18	ketamine	ketamine	PROPN
biomedich-945	55	19	-	-	PUNCT
biomedich-945	55	20	xylazine	xylazine	PROPN
biomedich-945	55	21	anesthesia	anesthesia	PROPN
biomedich-945	55	22	.	.	PUNCT
biomedich-945	56	1	the	the	DET
biomedich-945	56	2	stomachs	stomach	NOUN
biomedich-945	56	3	were	be	AUX
biomedich-945	56	4	excised	excise	VERB
biomedich-945	56	5	,	,	PUNCT
biomedich-945	56	6	opened	open	VERB
biomedich-945	56	7	along	along	ADP
biomedich-945	56	8	the	the	DET
biomedich-945	56	9	greater	great	ADJ
biomedich-945	56	10	curvature	curvature	NOUN
biomedich-945	56	11	,	,	PUNCT
biomedich-945	56	12	and	and	CCONJ
biomedich-945	56	13	rinsed	rinse	VERB
biomedich-945	56	14	with	with	ADP
biomedich-945	56	15	normal	normal	ADJ
biomedich-945	56	16	saline	saline	NOUN
biomedich-945	56	17	to	to	PART
biomedich-945	56	18	remove	remove	VERB
biomedich-945	56	19	gastric	gastric	ADJ
biomedich-945	56	20	contents	content	NOUN
biomedich-945	56	21	.	.	PUNCT
biomedich-945	57	1	tissue	tissue	NOUN
biomedich-945	57	2	samples	sample	NOUN
biomedich-945	57	3	from	from	ADP
biomedich-945	57	4	the	the	DET
biomedich-945	57	5	gastric	gastric	ADJ
biomedich-945	57	6	body	body	NOUN
biomedich-945	57	7	were	be	AUX
biomedich-945	57	8	fixed	fix	VERB
biomedich-945	57	9	in	in	ADP
biomedich-945	57	10	10	10	NUM
biomedich-945	57	11	%	%	NOUN
biomedich-945	57	12	neutral	neutral	ADJ
biomedich-945	57	13	buffered	buffer	VERB
biomedich-945	57	14	formalin	formalin	NOUN
biomedich-945	57	15	for	for	ADP
biomedich-945	57	16	histological	histological	ADJ
biomedich-945	57	17	analysis	analysis	NOUN
biomedich-945	57	18	.	.	PUNCT
biomedich-945	58	1	histopathological	histopathological	ADJ
biomedich-945	58	2	examination	examination	NOUN
biomedich-945	58	3	fixed	fix	VERB
biomedich-945	58	4	tissues	tissue	NOUN
biomedich-945	58	5	were	be	AUX
biomedich-945	58	6	processed	process	VERB
biomedich-945	58	7	using	use	VERB
biomedich-945	58	8	standard	standard	ADJ
biomedich-945	58	9	paraffinembedding	paraffinembedde	VERB
biomedich-945	58	10	techniques	technique	NOUN
biomedich-945	58	11	.	.	PUNCT
biomedich-945	59	1	sections	section	NOUN
biomedich-945	59	2	of	of	ADP
biomedich-945	59	3	5	5	NUM
biomedich-945	59	4	µm	µm	NOUN
biomedich-945	59	5	thickness	thickness	NOUN
biomedich-945	59	6	were	be	AUX
biomedich-945	59	7	stained	stain	VERB
biomedich-945	59	8	with	with	ADP
biomedich-945	59	9	hematoxylin	hematoxylin	NOUN
biomedich-945	59	10	and	and	CCONJ
biomedich-945	59	11	eosin	eosin	NOUN
biomedich-945	59	12	(	(	PUNCT
biomedich-945	59	13	h&e	h&e	PROPN
biomedich-945	59	14	)	)	PUNCT
biomedich-945	59	15	.	.	PUNCT
biomedich-945	60	1	histopathological	histopathological	ADJ
biomedich-945	60	2	evaluation	evaluation	NOUN
biomedich-945	60	3	was	be	AUX
biomedich-945	60	4	performed	perform	VERB
biomedich-945	60	5	under	under	ADP
biomedich-945	60	6	a	a	DET
biomedich-945	60	7	light	light	ADJ
biomedich-945	60	8	microscope	microscope	NOUN
biomedich-945	60	9	(	(	PUNCT
biomedich-945	60	10	400×	400×	NOUN
biomedich-945	60	11	magnification	magnification	NOUN
biomedich-945	60	12	)	)	PUNCT
biomedich-945	60	13	.	.	PUNCT
biomedich-945	61	1	histopathological	histopathological	ADJ
biomedich-945	61	2	scoring	score	VERB
biomedich-945	61	3	gastric	gastric	ADJ
biomedich-945	61	4	mucosal	mucosal	NOUN
biomedich-945	61	5	alterations	alteration	NOUN
biomedich-945	61	6	were	be	AUX
biomedich-945	61	7	assessed	assess	VERB
biomedich-945	61	8	semiquantitatively	semiquantitatively	ADV
biomedich-945	61	9	using	use	VERB
biomedich-945	61	10	a	a	DET
biomedich-945	61	11	modified	modify	VERB
biomedich-945	61	12	scoring	scoring	NOUN
biomedich-945	61	13	system	system	NOUN
biomedich-945	61	14	,	,	PUNCT
biomedich-945	61	15	including	include	VERB
biomedich-945	61	16	parameters	parameter	NOUN
biomedich-945	61	17	such	such	ADJ
biomedich-945	61	18	as	as	ADP
biomedich-945	61	19	:	:	PUNCT
biomedich-945	61	20	savitri	savitri	PROPN
biomedich-945	61	21	et	et	PROPN
biomedich-945	61	22	al	al	PROPN
biomedich-945	61	23	.	.	PROPN
biomedich-945	61	24	–	–	PUNCT
biomedich-945	61	25	effect	effect	NOUN
biomedich-945	61	26	of	of	ADP
biomedich-945	61	27	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	61	28	administration	administration	NOUN
biomedich-945	61	29	on	on	ADP
biomedich-945	61	30	gastric	gastric	ADJ
biomedich-945	61	31	histopathological	histopathological	ADJ
biomedich-945	61	32	…	…	PUNCT
biomedich-945	61	33	875	875	NUM
biomedich-945	61	34	a.	a.	NOUN
biomedich-945	61	35	epithelial	epithelial	ADJ
biomedich-945	61	36	erosion	erosion	NOUN
biomedich-945	61	37	/	/	SYM
biomedich-945	61	38	ulceration	ulceration	NOUN
biomedich-945	61	39	(	(	PUNCT
biomedich-945	61	40	0	0	NUM
biomedich-945	61	41	=	=	SYM
biomedich-945	61	42	absent	absent	ADJ
biomedich-945	61	43	,	,	PUNCT
biomedich-945	61	44	1	1	NUM
biomedich-945	61	45	=	=	SYM
biomedich-945	61	46	mild	mild	ADJ
biomedich-945	61	47	,	,	PUNCT
biomedich-945	61	48	2	2	NUM
biomedich-945	61	49	=	=	SYM
biomedich-945	61	50	moderate	moderate	ADJ
biomedich-945	61	51	,	,	PUNCT
biomedich-945	61	52	3	3	NUM
biomedich-945	61	53	=	=	SYM
biomedich-945	61	54	severe	severe	ADJ
biomedich-945	61	55	)	)	PUNCT
biomedich-945	61	56	b.	b.	NOUN
biomedich-945	61	57	inflammatory	inflammatory	ADJ
biomedich-945	61	58	cell	cell	NOUN
biomedich-945	61	59	infiltration	infiltration	NOUN
biomedich-945	61	60	(	(	PUNCT
biomedich-945	61	61	0	0	NUM
biomedich-945	61	62	=	=	SYM
biomedich-945	61	63	absent	absent	ADJ
biomedich-945	61	64	,	,	PUNCT
biomedich-945	61	65	1	1	NUM
biomedich-945	61	66	=	=	SYM
biomedich-945	61	67	mild	mild	ADJ
biomedich-945	61	68	,	,	PUNCT
biomedich-945	61	69	2	2	NUM
biomedich-945	61	70	=	=	SYM
biomedich-945	61	71	moderate	moderate	ADJ
biomedich-945	61	72	,	,	PUNCT
biomedich-945	61	73	3	3	NUM
biomedich-945	61	74	=	=	SYM
biomedich-945	61	75	severe	severe	ADJ
biomedich-945	61	76	)	)	PUNCT
biomedich-945	61	77	c.	c.	NOUN
biomedich-945	61	78	edema	edema	PROPN
biomedich-945	61	79	and	and	CCONJ
biomedich-945	61	80	vascular	vascular	ADJ
biomedich-945	61	81	congestion	congestion	NOUN
biomedich-945	61	82	(	(	PUNCT
biomedich-945	61	83	0	0	NUM
biomedich-945	61	84	=	=	SYM
biomedich-945	61	85	absent	absent	ADJ
biomedich-945	61	86	,	,	PUNCT
biomedich-945	61	87	1	1	NUM
biomedich-945	61	88	=	=	SYM
biomedich-945	61	89	mild	mild	ADJ
biomedich-945	61	90	,	,	PUNCT
biomedich-945	61	91	2	2	NUM
biomedich-945	61	92	=	=	SYM
biomedich-945	61	93	moderate	moderate	ADJ
biomedich-945	61	94	,	,	PUNCT
biomedich-945	61	95	3	3	NUM
biomedich-945	61	96	=	=	SYM
biomedich-945	61	97	severe	severe	X
biomedich-945	61	98	)	)	PUNCT
biomedich-945	61	99	d.	d.	PROPN
biomedich-945	61	100	mucosal	mucosal	NOUN
biomedich-945	61	101	thickness	thickness	NOUN
biomedich-945	61	102	changes	change	NOUN
biomedich-945	61	103	(	(	PUNCT
biomedich-945	61	104	normal	normal	ADJ
biomedich-945	61	105	,	,	PUNCT
biomedich-945	61	106	thinned	thin	VERB
biomedich-945	61	107	,	,	PUNCT
biomedich-945	61	108	or	or	CCONJ
biomedich-945	61	109	thickened	thicken	VERB
biomedich-945	61	110	)	)	PUNCT
biomedich-945	61	111	two	two	NUM
biomedich-945	61	112	independent	independent	ADJ
biomedich-945	61	113	pathologists	pathologist	NOUN
biomedich-945	61	114	blinded	blind	VERB
biomedich-945	61	115	to	to	ADP
biomedich-945	61	116	the	the	DET
biomedich-945	61	117	treatment	treatment	NOUN
biomedich-945	61	118	groups	group	NOUN
biomedich-945	61	119	performed	perform	VERB
biomedich-945	61	120	the	the	DET
biomedich-945	61	121	evaluations	evaluation	NOUN
biomedich-945	61	122	to	to	PART
biomedich-945	61	123	minimize	minimize	VERB
biomedich-945	61	124	observer	observer	NOUN
biomedich-945	61	125	bias	bias	NOUN
biomedich-945	61	126	.	.	PUNCT
biomedich-945	62	1	statistical	statistical	ADJ
biomedich-945	62	2	analysis	analysis	NOUN
biomedich-945	62	3	data	datum	NOUN
biomedich-945	62	4	were	be	AUX
biomedich-945	62	5	expressed	express	VERB
biomedich-945	62	6	as	as	ADP
biomedich-945	62	7	mean	mean	NOUN
biomedich-945	62	8	±	±	NUM
biomedich-945	62	9	standard	standard	ADJ
biomedich-945	62	10	deviation	deviation	NOUN
biomedich-945	62	11	(	(	PUNCT
biomedich-945	62	12	sd	sd	NOUN
biomedich-945	62	13	)	)	PUNCT
biomedich-945	62	14	.	.	PUNCT
biomedich-945	63	1	differences	difference	NOUN
biomedich-945	63	2	between	between	ADP
biomedich-945	63	3	groups	group	NOUN
biomedich-945	63	4	were	be	AUX
biomedich-945	63	5	analyzed	analyze	VERB
biomedich-945	63	6	using	use	VERB
biomedich-945	63	7	oneway	oneway	PROPN
biomedich-945	63	8	anova	anova	PROPN
biomedich-945	63	9	followed	follow	VERB
biomedich-945	63	10	by	by	ADP
biomedich-945	63	11	tukey	tukey	PROPN
biomedich-945	63	12	’s	’s	PART
biomedich-945	63	13	post	post	X
biomedich-945	63	14	hoc	hoc	X
biomedich-945	63	15	test	test	NOUN
biomedich-945	63	16	.	.	PUNCT
biomedich-945	64	1	a	a	DET
biomedich-945	64	2	pvalue	pvalue	NOUN
biomedich-945	64	3	<	<	NOUN
biomedich-945	64	4	0.05	0.05	NUM
biomedich-945	64	5	was	be	AUX
biomedich-945	64	6	considered	consider	VERB
biomedich-945	64	7	statistically	statistically	ADV
biomedich-945	64	8	significant	significant	ADJ
biomedich-945	64	9	.	.	PUNCT
biomedich-945	65	1	statistical	statistical	ADJ
biomedich-945	65	2	analyses	analysis	NOUN
biomedich-945	65	3	were	be	AUX
biomedich-945	65	4	conducted	conduct	VERB
biomedich-945	65	5	using	use	VERB
biomedich-945	65	6	spss	spss	PROPN
biomedich-945	65	7	version	version	NOUN
biomedich-945	65	8	26	26	NUM
biomedich-945	65	9	.	.	PUNCT
biomedich-945	66	1	results	result	NOUN
biomedich-945	66	2	and	and	CCONJ
biomedich-945	66	3	discussion	discussion	NOUN
biomedich-945	66	4	result	result	VERB
biomedich-945	66	5	general	general	ADJ
biomedich-945	66	6	observations	observation	NOUN
biomedich-945	66	7	throughout	throughout	ADP
biomedich-945	66	8	the	the	DET
biomedich-945	66	9	experimental	experimental	ADJ
biomedich-945	66	10	period	period	NOUN
biomedich-945	66	11	,	,	PUNCT
biomedich-945	66	12	no	no	DET
biomedich-945	66	13	mortality	mortality	NOUN
biomedich-945	66	14	was	be	AUX
biomedich-945	66	15	observed	observe	VERB
biomedich-945	66	16	in	in	ADP
biomedich-945	66	17	any	any	PRON
biomedich-945	66	18	of	of	ADP
biomedich-945	66	19	the	the	DET
biomedich-945	66	20	groups	group	NOUN
biomedich-945	66	21	.	.	PUNCT
biomedich-945	67	1	mice	mouse	NOUN
biomedich-945	67	2	in	in	ADP
biomedich-945	67	3	the	the	DET
biomedich-945	67	4	ciprofloxacintreated	ciprofloxacintreate	VERB
biomedich-945	67	5	groups	group	NOUN
biomedich-945	67	6	(	(	PUNCT
biomedich-945	67	7	especially	especially	ADV
biomedich-945	67	8	at	at	ADP
biomedich-945	67	9	moderate	moderate	ADJ
biomedich-945	67	10	and	and	CCONJ
biomedich-945	67	11	high	high	ADJ
biomedich-945	67	12	doses	dose	NOUN
biomedich-945	67	13	)	)	PUNCT
biomedich-945	67	14	exhibited	exhibit	VERB
biomedich-945	67	15	reduced	reduce	VERB
biomedich-945	67	16	activity	activity	NOUN
biomedich-945	67	17	and	and	CCONJ
biomedich-945	67	18	occasionally	occasionally	ADV
biomedich-945	67	19	experienced	experienced	ADJ
biomedich-945	67	20	mild	mild	ADJ
biomedich-945	67	21	diarrhea	diarrhea	NOUN
biomedich-945	67	22	compared	compare	VERB
biomedich-945	67	23	to	to	ADP
biomedich-945	67	24	the	the	DET
biomedich-945	67	25	control	control	NOUN
biomedich-945	67	26	group	group	NOUN
biomedich-945	67	27	.	.	PUNCT
biomedich-945	68	1	body	body	NOUN
biomedich-945	68	2	weight	weight	NOUN
biomedich-945	68	3	changes	change	NOUN
biomedich-945	68	4	were	be	AUX
biomedich-945	68	5	not	not	PART
biomedich-945	68	6	significantly	significantly	ADV
biomedich-945	68	7	different	different	ADJ
biomedich-945	68	8	among	among	ADP
biomedich-945	68	9	groups	group	NOUN
biomedich-945	68	10	(	(	PUNCT
biomedich-945	68	11	p	p	X
biomedich-945	68	12	>	>	X
biomedich-945	68	13	0.05	0.05	NUM
biomedich-945	68	14	)	)	PUNCT
biomedich-945	68	15	(	(	PUNCT
biomedich-945	68	16	table	table	NOUN
biomedich-945	68	17	1	1	NUM
biomedich-945	68	18	)	)	PUNCT
biomedich-945	68	19	.	.	PUNCT
biomedich-945	69	1	table	table	NOUN
biomedich-945	69	2	1	1	NUM
biomedich-945	69	3	.	.	PUNCT
biomedich-945	70	1	histopathological	histopathological	ADJ
biomedich-945	70	2	scores	score	NOUN
biomedich-945	70	3	of	of	ADP
biomedich-945	70	4	gastric	gastric	ADJ
biomedich-945	70	5	tissue	tissue	NOUN
biomedich-945	70	6	in	in	ADP
biomedich-945	70	7	different	different	ADJ
biomedich-945	70	8	treatment	treatment	NOUN
biomedich-945	70	9	groups	group	NOUN
biomedich-945	70	10	.	.	PUNCT
biomedich-945	71	1	group	group	NOUN
biomedich-945	71	2	erosion	erosion	NOUN
biomedich-945	71	3	/	/	SYM
biomedich-945	71	4	ulceration	ulceration	NOUN
biomedich-945	71	5	(	(	PUNCT
biomedich-945	71	6	0–3	0–3	NOUN
biomedich-945	71	7	)	)	PUNCT
biomedich-945	71	8	inflammation	inflammation	NOUN
biomedich-945	71	9	(	(	PUNCT
biomedich-945	71	10	0–3	0–3	NOUN
biomedich-945	71	11	)	)	PUNCT
biomedich-945	71	12	vascular	vascular	ADJ
biomedich-945	71	13	congestion	congestion	NOUN
biomedich-945	71	14	(	(	PUNCT
biomedich-945	71	15	0–3	0–3	NOUN
biomedich-945	71	16	)	)	PUNCT
biomedich-945	71	17	mucosal	mucosal	NOUN
biomedich-945	71	18	thickness	thickness	NOUN
biomedich-945	71	19	alteration	alteration	NOUN
biomedich-945	71	20	(	(	PUNCT
biomedich-945	71	21	0–3	0–3	NOUN
biomedich-945	71	22	)	)	PUNCT
biomedich-945	71	23	total	total	ADJ
biomedich-945	71	24	score	score	NOUN
biomedich-945	71	25	(	(	PUNCT
biomedich-945	71	26	0–12	0–12	NOUN
biomedich-945	71	27	)	)	PUNCT
biomedich-945	71	28	control	control	NOUN
biomedich-945	71	29	0.2	0.2	NUM
biomedich-945	71	30	±	±	NUM
biomedich-945	71	31	0.4	0.4	NUM
biomedich-945	71	32	0.3	0.3	NUM
biomedich-945	71	33	±	±	NUM
biomedich-945	71	34	0.5	0.5	NUM
biomedich-945	71	35	0.2	0.2	NUM
biomedich-945	71	36	±	±	NUM
biomedich-945	71	37	0.4	0.4	NUM
biomedich-945	71	38	0.1	0.1	NUM
biomedich-945	71	39	±	±	NUM
biomedich-945	71	40	0.3	0.3	NUM
biomedich-945	71	41	0.8	0.8	NUM
biomedich-945	71	42	±	±	NUM
biomedich-945	71	43	0.7	0.7	NUM
biomedich-945	71	44	low	low	ADV
biomedich-945	71	45	-	-	PUNCT
biomedich-945	71	46	dose	dose	NOUN
biomedich-945	71	47	(	(	PUNCT
biomedich-945	71	48	10	10	NUM
biomedich-945	71	49	mg	mg	PROPN
biomedich-945	71	50	/	/	SYM
biomedich-945	71	51	kg	kg	NOUN
biomedich-945	71	52	)	)	PUNCT
biomedich-945	71	53	0.8	0.8	NUM
biomedich-945	71	54	±	±	NUM
biomedich-945	71	55	0.7	0.7	NUM
biomedich-945	71	56	1.0	1.0	NUM
biomedich-945	71	57	±	±	NUM
biomedich-945	71	58	0.6	0.6	NUM
biomedich-945	71	59	0.9	0.9	NUM
biomedich-945	71	60	±	±	NUM
biomedich-945	71	61	0.6	0.6	NUM
biomedich-945	71	62	0.7	0.7	NUM
biomedich-945	71	63	±	±	NUM
biomedich-945	71	64	0.5	0.5	NUM
biomedich-945	71	65	3.4	3.4	NUM
biomedich-945	71	66	±	±	NUM
biomedich-945	71	67	1.1	1.1	NUM
biomedich-945	71	68	*	*	PUNCT
biomedich-945	71	69	moderate	moderate	ADJ
biomedich-945	71	70	-	-	PUNCT
biomedich-945	71	71	dose	dose	NOUN
biomedich-945	71	72	(	(	PUNCT
biomedich-945	71	73	20	20	NUM
biomedich-945	71	74	mg	mg	NUM
biomedich-945	71	75	/	/	SYM
biomedich-945	71	76	kg	kg	NOUN
biomedich-945	71	77	)	)	PUNCT
biomedich-945	71	78	1.7	1.7	NUM
biomedich-945	71	79	±	±	NUM
biomedich-945	71	80	0.8	0.8	NUM
biomedich-945	71	81	1.9	1.9	NUM
biomedich-945	71	82	±	±	NUM
biomedich-945	71	83	0.7	0.7	NUM
biomedich-945	71	84	1.6	1.6	NUM
biomedich-945	71	85	±	±	NUM
biomedich-945	71	86	0.8	0.8	NUM
biomedich-945	71	87	1.5	1.5	NUM
biomedich-945	71	88	±	±	NUM
biomedich-945	71	89	0.6	0.6	NUM
biomedich-945	71	90	6.7	6.7	NUM
biomedich-945	71	91	±	±	NUM
biomedich-945	71	92	1.5	1.5	NUM
biomedich-945	71	93	*	*	NOUN
biomedich-945	71	94	*	*	NOUN
biomedich-945	71	95	high	high	ADV
biomedich-945	71	96	-	-	PUNCT
biomedich-945	71	97	dose	dose	NOUN
biomedich-945	71	98	(	(	PUNCT
biomedich-945	71	99	40	40	NUM
biomedich-945	71	100	mg	mg	PROPN
biomedich-945	71	101	/	/	SYM
biomedich-945	71	102	kg	kg	NOUN
biomedich-945	71	103	)	)	PUNCT
biomedich-945	71	104	2.8	2.8	NUM
biomedich-945	71	105	±	±	NUM
biomedich-945	71	106	0.4	0.4	NUM
biomedich-945	71	107	2.7	2.7	NUM
biomedich-945	71	108	±	±	NUM
biomedich-945	71	109	0.5	0.5	NUM
biomedich-945	71	110	2.6	2.6	NUM
biomedich-945	71	111	±	±	NUM
biomedich-945	71	112	0.5	0.5	NUM
biomedich-945	71	113	2.5	2.5	NUM
biomedich-945	71	114	±	±	NUM
biomedich-945	71	115	0.5	0.5	NUM
biomedich-945	71	116	10.6	10.6	NUM
biomedich-945	71	117	±	±	NUM
biomedich-945	71	118	1.2	1.2	NUM
biomedich-945	71	119	*	*	PUNCT
biomedich-945	71	120	*	*	PUNCT
biomedich-945	71	121	*	*	PUNCT
biomedich-945	71	122	*	*	PUNCT
biomedich-945	71	123	significantly	significantly	ADV
biomedich-945	71	124	different	different	ADJ
biomedich-945	71	125	from	from	ADP
biomedich-945	71	126	control	control	NOUN
biomedich-945	71	127	(	(	PUNCT
biomedich-945	71	128	p	p	X
biomedich-945	71	129	<	<	X
biomedich-945	71	130	0.05	0.05	NUM
biomedich-945	71	131	)	)	PUNCT
biomedich-945	71	132	.	.	PUNCT
biomedich-945	72	1	*	*	PUNCT
biomedich-945	73	1	*	*	PUNCT
biomedich-945	73	2	highly	highly	ADV
biomedich-945	73	3	significant	significant	ADJ
biomedich-945	73	4	vs.	vs.	ADP
biomedich-945	73	5	control	control	NOUN
biomedich-945	73	6	(	(	PUNCT
biomedich-945	73	7	p	p	X
biomedich-945	73	8	<	<	X
biomedich-945	73	9	0.01).***very	0.01).***very	NUM
biomedich-945	73	10	highly	highly	ADV
biomedich-945	73	11	significant	significant	ADJ
biomedich-945	73	12	vs.	vs.	ADP
biomedich-945	73	13	control	control	NOUN
biomedich-945	73	14	(	(	PUNCT
biomedich-945	73	15	p	p	X
biomedich-945	73	16	<	<	X
biomedich-945	73	17	0.001	0.001	NUM
biomedich-945	73	18	)	)	PUNCT
biomedich-945	73	19	.	.	PUNCT
biomedich-945	74	1	histopathological	histopathological	ADJ
biomedich-945	74	2	findings	finding	NOUN
biomedich-945	74	3	histological	histological	ADJ
biomedich-945	74	4	examination	examination	NOUN
biomedich-945	74	5	of	of	ADP
biomedich-945	74	6	the	the	DET
biomedich-945	74	7	gastric	gastric	ADJ
biomedich-945	74	8	tissues	tissue	NOUN
biomedich-945	74	9	revealed	reveal	VERB
biomedich-945	74	10	normal	normal	ADJ
biomedich-945	74	11	mucosal	mucosal	NOUN
biomedich-945	74	12	architecture	architecture	NOUN
biomedich-945	74	13	in	in	ADP
biomedich-945	74	14	the	the	DET
biomedich-945	74	15	control	control	NOUN
biomedich-945	74	16	group	group	NOUN
biomedich-945	74	17	,	,	PUNCT
biomedich-945	74	18	characterised	characterise	VERB
biomedich-945	74	19	by	by	ADP
biomedich-945	74	20	an	an	DET
biomedich-945	74	21	intact	intact	ADJ
biomedich-945	74	22	epithelial	epithelial	ADJ
biomedich-945	74	23	lining	lining	NOUN
biomedich-945	74	24	and	and	CCONJ
biomedich-945	74	25	no	no	DET
biomedich-945	74	26	evidence	evidence	NOUN
biomedich-945	74	27	of	of	ADP
biomedich-945	74	28	inflammation	inflammation	NOUN
biomedich-945	74	29	or	or	CCONJ
biomedich-945	74	30	ulceration	ulceration	NOUN
biomedich-945	74	31	.	.	PUNCT
biomedich-945	75	1	in	in	ADP
biomedich-945	75	2	contrast	contrast	NOUN
biomedich-945	75	3	,	,	PUNCT
biomedich-945	75	4	mice	mouse	NOUN
biomedich-945	75	5	administered	administer	VERB
biomedich-945	75	6	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	75	7	exhibited	exhibit	VERB
biomedich-945	75	8	dose	dose	NOUN
biomedich-945	75	9	-	-	PUNCT
biomedich-945	75	10	dependent	dependent	ADJ
biomedich-945	75	11	alterations	alteration	NOUN
biomedich-945	75	12	in	in	ADP
biomedich-945	75	13	gastric	gastric	ADJ
biomedich-945	75	14	histopathology	histopathology	NOUN
biomedich-945	75	15	.	.	PUNCT
biomedich-945	76	1	a.	a.	PROPN
biomedich-945	76	2	low	low	ADV
biomedich-945	76	3	-	-	PUNCT
biomedich-945	76	4	dose	dose	NOUN
biomedich-945	76	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	76	6	(	(	PUNCT
biomedich-945	76	7	10	10	NUM
biomedich-945	76	8	mg	mg	NUM
biomedich-945	76	9	/	/	SYM
biomedich-945	76	10	kg	kg	NOUN
biomedich-945	76	11	):	):	PUNCT
biomedich-945	76	12	mild	mild	ADJ
biomedich-945	76	13	epithelial	epithelial	ADJ
biomedich-945	76	14	erosion	erosion	NOUN
biomedich-945	76	15	and	and	CCONJ
biomedich-945	76	16	minimal	minimal	ADJ
biomedich-945	76	17	inflammatory	inflammatory	ADJ
biomedich-945	76	18	cell	cell	NOUN
biomedich-945	76	19	infiltration	infiltration	NOUN
biomedich-945	76	20	were	be	AUX
biomedich-945	76	21	observed	observe	VERB
biomedich-945	76	22	in	in	ADP
biomedich-945	76	23	some	some	DET
biomedich-945	76	24	samples	sample	NOUN
biomedich-945	76	25	.	.	PUNCT
biomedich-945	77	1	b.	b.	PROPN
biomedich-945	77	2	moderate	moderate	ADJ
biomedich-945	77	3	-	-	PUNCT
biomedich-945	77	4	dose	dose	NOUN
biomedich-945	77	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	77	6	(	(	PUNCT
biomedich-945	77	7	20	20	NUM
biomedich-945	77	8	mg	mg	NUM
biomedich-945	77	9	/	/	SYM
biomedich-945	77	10	kg	kg	PROPN
biomedich-945	77	11	):	):	PUNCT
biomedich-945	77	12	moderate	moderate	ADJ
biomedich-945	77	13	epithelial	epithelial	ADJ
biomedich-945	77	14	disruption	disruption	NOUN
biomedich-945	77	15	,	,	PUNCT
biomedich-945	77	16	inflammatory	inflammatory	ADJ
biomedich-945	77	17	infiltration	infiltration	NOUN
biomedich-945	77	18	in	in	ADP
biomedich-945	77	19	the	the	DET
biomedich-945	77	20	lamina	lamina	ADJ
biomedich-945	77	21	propria	propria	NOUN
biomedich-945	77	22	,	,	PUNCT
biomedich-945	77	23	and	and	CCONJ
biomedich-945	77	24	vascular	vascular	ADJ
biomedich-945	77	25	congestion	congestion	NOUN
biomedich-945	77	26	were	be	AUX
biomedich-945	77	27	evident	evident	ADJ
biomedich-945	77	28	.	.	PUNCT
biomedich-945	78	1	c.	c.	PROPN
biomedich-945	78	2	high	high	ADV
biomedich-945	78	3	-	-	PUNCT
biomedich-945	78	4	dose	dose	NOUN
biomedich-945	78	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	78	6	(	(	PUNCT
biomedich-945	78	7	40	40	NUM
biomedich-945	78	8	mg	mg	PROPN
biomedich-945	78	9	/	/	SYM
biomedich-945	78	10	kg	kg	PROPN
biomedich-945	78	11	):	):	PUNCT
biomedich-945	78	12	severe	severe	ADJ
biomedich-945	78	13	epithelial	epithelial	ADJ
biomedich-945	78	14	erosion	erosion	NOUN
biomedich-945	78	15	/	/	SYM
biomedich-945	78	16	ulceration	ulceration	NOUN
biomedich-945	78	17	,	,	PUNCT
biomedich-945	78	18	marked	mark	VERB
biomedich-945	78	19	inflammatory	inflammatory	ADJ
biomedich-945	78	20	infiltration	infiltration	NOUN
biomedich-945	78	21	,	,	PUNCT
biomedich-945	78	22	edema	edema	NOUN
biomedich-945	78	23	,	,	PUNCT
biomedich-945	78	24	and	and	CCONJ
biomedich-945	78	25	thinning	thinning	NOUN
biomedich-945	78	26	of	of	ADP
biomedich-945	78	27	mucosal	mucosal	NOUN
biomedich-945	78	28	layers	layer	NOUN
biomedich-945	78	29	were	be	AUX
biomedich-945	78	30	consistently	consistently	ADV
biomedich-945	78	31	observed	observe	VERB
biomedich-945	78	32	.	.	PUNCT
biomedich-945	79	1	representative	representative	ADJ
biomedich-945	79	2	microphotographs	microphotograph	NOUN
biomedich-945	79	3	of	of	ADP
biomedich-945	79	4	h&e	h&e	PROPN
biomedich-945	79	5	-	-	PUNCT
biomedich-945	79	6	stained	stain	VERB
biomedich-945	79	7	sections	section	NOUN
biomedich-945	79	8	demonstrated	demonstrate	VERB
biomedich-945	79	9	progressive	progressive	ADJ
biomedich-945	79	10	mucosal	mucosal	NOUN
biomedich-945	79	11	damage	damage	NOUN
biomedich-945	79	12	corresponding	correspond	VERB
biomedich-945	79	13	to	to	ADP
biomedich-945	79	14	increasing	increase	VERB
biomedich-945	79	15	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	79	16	doses	dose	NOUN
biomedich-945	79	17	(	(	PUNCT
biomedich-945	79	18	figure	figure	NOUN
biomedich-945	79	19	1	1	NUM
biomedich-945	79	20	)	)	PUNCT
biomedich-945	79	21	.	.	PUNCT
biomedich-945	80	1	876	876	NUM
biomedich-945	80	2	biology	biology	NOUN
biomedich-945	80	3	,	,	PUNCT
biomedich-945	80	4	medicine	medicine	NOUN
biomedich-945	80	5	,	,	PUNCT
biomedich-945	80	6	&	&	CCONJ
biomedich-945	80	7	natural	natural	ADJ
biomedich-945	80	8	product	product	NOUN
biomedich-945	80	9	chemistry	chemistry	NOUN
biomedich-945	80	10	14	14	NUM
biomedich-945	80	11	(	(	PUNCT
biomedich-945	80	12	2	2	NUM
biomedich-945	80	13	)	)	PUNCT
biomedich-945	80	14	,	,	PUNCT
biomedich-945	80	15	2025	2025	NUM
biomedich-945	80	16	:	:	PUNCT
biomedich-945	80	17	873	873	NUM
biomedich-945	80	18	-	-	SYM
biomedich-945	80	19	878	878	NUM
biomedich-945	80	20	figure	figure	NOUN
biomedich-945	80	21	1	1	NUM
biomedich-945	80	22	.	.	PUNCT
biomedich-945	81	1	histopathological	histopathological	ADJ
biomedich-945	81	2	scores	score	NOUN
biomedich-945	81	3	of	of	ADP
biomedich-945	81	4	gastric	gastric	ADJ
biomedich-945	81	5	tissue	tissue	NOUN
biomedich-945	81	6	in	in	ADP
biomedich-945	81	7	different	different	ADJ
biomedich-945	81	8	treatment	treatment	NOUN
biomedich-945	81	9	groups	group	NOUN
biomedich-945	81	10	.	.	PUNCT
biomedich-945	82	1	a.	a.	NOUN
biomedich-945	82	2	group	group	NOUN
biomedich-945	82	3	i	i	PRON
biomedich-945	82	4	(	(	PUNCT
biomedich-945	82	5	control	control	PROPN
biomedich-945	82	6	):	):	PUNCT
biomedich-945	82	7	received	receive	VERB
biomedich-945	82	8	distilled	distil	VERB
biomedich-945	82	9	water	water	NOUN
biomedich-945	82	10	orally	orally	ADV
biomedich-945	82	11	,	,	PUNCT
biomedich-945	82	12	b.	b.	PROPN
biomedich-945	82	13	group	group	PROPN
biomedich-945	82	14	ii	ii	PROPN
biomedich-945	82	15	(	(	PUNCT
biomedich-945	82	16	lowdose	lowdose	ADJ
biomedich-945	82	17	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	82	18	):	):	PUNCT
biomedich-945	82	19	received	receive	VERB
biomedich-945	82	20	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	82	21	10	10	NUM
biomedich-945	82	22	mg	mg	NUM
biomedich-945	82	23	/	/	SYM
biomedich-945	82	24	kg	kg	NOUN
biomedich-945	82	25	/	/	SYM
biomedich-945	82	26	day	day	NOUN
biomedich-945	82	27	orally	orally	ADV
biomedich-945	82	28	,	,	PUNCT
biomedich-945	82	29	c.	c.	PROPN
biomedich-945	82	30	group	group	PROPN
biomedich-945	82	31	iii	iii	PROPN
biomedich-945	82	32	(	(	PUNCT
biomedich-945	82	33	moderate	moderate	ADJ
biomedich-945	82	34	-	-	PUNCT
biomedich-945	82	35	dose	dose	NOUN
biomedich-945	82	36	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	82	37	):	):	PUNCT
biomedich-945	82	38	received	receive	VERB
biomedich-945	82	39	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	82	40	20	20	NUM
biomedich-945	82	41	mg	mg	NUM
biomedich-945	82	42	/	/	SYM
biomedich-945	82	43	kg	kg	PROPN
biomedich-945	82	44	/	/	SYM
biomedich-945	82	45	day	day	NOUN
biomedich-945	82	46	orally	orally	ADV
biomedich-945	82	47	,	,	PUNCT
biomedich-945	82	48	and	and	CCONJ
biomedich-945	82	49	d.	d.	PROPN
biomedich-945	82	50	group	group	PROPN
biomedich-945	82	51	iv	iv	PROPN
biomedich-945	82	52	(	(	PUNCT
biomedich-945	82	53	high	high	ADJ
biomedich-945	82	54	-	-	PUNCT
biomedich-945	82	55	dose	dose	NOUN
biomedich-945	82	56	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	82	57	):	):	PUNCT
biomedich-945	82	58	received	receive	VERB
biomedich-945	82	59	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	82	60	40	40	NUM
biomedich-945	82	61	mg	mg	NUM
biomedich-945	82	62	/	/	SYM
biomedich-945	82	63	kg	kg	PROPN
biomedich-945	82	64	/	/	SYM
biomedich-945	82	65	day	day	NOUN
biomedich-945	82	66	orally	orally	ADV
biomedich-945	82	67	.	.	PUNCT
biomedich-945	83	1	discussion	discussion	NOUN
biomedich-945	83	2	this	this	DET
biomedich-945	83	3	study	study	NOUN
biomedich-945	83	4	demonstrated	demonstrate	VERB
biomedich-945	83	5	that	that	SCONJ
biomedich-945	83	6	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	83	7	administration	administration	NOUN
biomedich-945	83	8	induced	induce	VERB
biomedich-945	83	9	dose	dose	NOUN
biomedich-945	83	10	-	-	PUNCT
biomedich-945	83	11	dependent	dependent	ADJ
biomedich-945	83	12	gastric	gastric	ADJ
biomedich-945	83	13	mucosal	mucosal	NOUN
biomedich-945	83	14	alterations	alteration	NOUN
biomedich-945	83	15	in	in	ADP
biomedich-945	83	16	mice	mouse	NOUN
biomedich-945	83	17	.	.	PUNCT
biomedich-945	84	1	the	the	DET
biomedich-945	84	2	control	control	PROPN
biomedich-945	84	3	group	group	NOUN
biomedich-945	84	4	exhibited	exhibit	VERB
biomedich-945	84	5	normal	normal	ADJ
biomedich-945	84	6	gastric	gastric	ADJ
biomedich-945	84	7	architecture	architecture	NOUN
biomedich-945	84	8	,	,	PUNCT
biomedich-945	84	9	while	while	SCONJ
biomedich-945	84	10	low	low	ADJ
biomedich-945	84	11	-	-	PUNCT
biomedich-945	84	12	dose	dose	NOUN
biomedich-945	84	13	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	84	14	caused	cause	VERB
biomedich-945	84	15	mild	mild	ADJ
biomedich-945	84	16	epithelial	epithelial	ADJ
biomedich-945	84	17	erosion	erosion	NOUN
biomedich-945	84	18	.	.	PUNCT
biomedich-945	85	1	moderate	moderate	ADJ
biomedich-945	85	2	doses	dose	NOUN
biomedich-945	85	3	resulted	result	VERB
biomedich-945	85	4	in	in	ADP
biomedich-945	85	5	mucosal	mucosal	ADJ
biomedich-945	85	6	disruption	disruption	NOUN
biomedich-945	85	7	with	with	ADP
biomedich-945	85	8	inflammatory	inflammatory	ADJ
biomedich-945	85	9	infiltration	infiltration	NOUN
biomedich-945	85	10	,	,	PUNCT
biomedich-945	85	11	and	and	CCONJ
biomedich-945	85	12	high	high	ADJ
biomedich-945	85	13	doses	dose	NOUN
biomedich-945	85	14	produced	produce	VERB
biomedich-945	85	15	severe	severe	ADJ
biomedich-945	85	16	ulceration	ulceration	NOUN
biomedich-945	85	17	,	,	PUNCT
biomedich-945	85	18	edema	edema	NOUN
biomedich-945	85	19	,	,	PUNCT
biomedich-945	85	20	and	and	CCONJ
biomedich-945	85	21	mucosal	mucosal	NOUN
biomedich-945	85	22	thinning	thin	VERB
biomedich-945	85	23	(	(	PUNCT
biomedich-945	85	24	islam	islam	PROPN
biomedich-945	85	25	et	et	PROPN
biomedich-945	85	26	al	al	PROPN
biomedich-945	85	27	.	.	PROPN
biomedich-945	85	28	,	,	PUNCT
biomedich-945	85	29	2024	2024	NUM
biomedich-945	85	30	)	)	PUNCT
biomedich-945	85	31	.	.	PUNCT
biomedich-945	86	1	these	these	DET
biomedich-945	86	2	findings	finding	NOUN
biomedich-945	86	3	suggest	suggest	VERB
biomedich-945	86	4	that	that	SCONJ
biomedich-945	86	5	repeated	repeat	VERB
biomedich-945	86	6	administration	administration	NOUN
biomedich-945	86	7	of	of	ADP
biomedich-945	86	8	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	86	9	may	may	AUX
biomedich-945	86	10	compromise	compromise	VERB
biomedich-945	86	11	gastric	gastric	ADJ
biomedich-945	86	12	mucosal	mucosal	NOUN
biomedich-945	86	13	integrity	integrity	NOUN
biomedich-945	86	14	(	(	PUNCT
biomedich-945	86	15	ge	ge	PROPN
biomedich-945	86	16	et	et	PROPN
biomedich-945	86	17	al	al	PROPN
biomedich-945	86	18	.	.	PROPN
biomedich-945	86	19	,	,	PUNCT
biomedich-945	86	20	2020	2020	NUM
biomedich-945	86	21	)	)	PUNCT
biomedich-945	86	22	.	.	PUNCT
biomedich-945	87	1	our	our	PRON
biomedich-945	87	2	results	result	NOUN
biomedich-945	87	3	are	be	AUX
biomedich-945	87	4	in	in	ADP
biomedich-945	87	5	agreement	agreement	NOUN
biomedich-945	87	6	with	with	ADP
biomedich-945	87	7	prior	prior	ADJ
biomedich-945	87	8	research	research	NOUN
biomedich-945	87	9	in	in	ADP
biomedich-945	87	10	rodents	rodent	NOUN
biomedich-945	87	11	.	.	PUNCT
biomedich-945	88	1	el	el	PROPN
biomedich-945	88	2	-	-	PUNCT
biomedich-945	88	3	masry	masry	PROPN
biomedich-945	88	4	,	,	PUNCT
biomedich-945	88	5	el	el	PROPN
biomedich-945	88	6	-	-	PUNCT
biomedich-945	88	7	baz	baz	PROPN
biomedich-945	88	8	,	,	PUNCT
biomedich-945	88	9	and	and	CCONJ
biomedich-945	88	10	ibrahim	ibrahim	PROPN
biomedich-945	88	11	(	(	PUNCT
biomedich-945	88	12	2021	2021	NUM
biomedich-945	88	13	)	)	PUNCT
biomedich-945	88	14	reported	report	VERB
biomedich-945	88	15	that	that	SCONJ
biomedich-945	88	16	prolonged	prolong	VERB
biomedich-945	88	17	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	88	18	exposure	exposure	NOUN
biomedich-945	88	19	in	in	ADP
biomedich-945	88	20	rats	rat	NOUN
biomedich-945	88	21	resulted	result	VERB
biomedich-945	88	22	in	in	ADP
biomedich-945	88	23	epithelial	epithelial	ADJ
biomedich-945	88	24	disruption	disruption	NOUN
biomedich-945	88	25	,	,	PUNCT
biomedich-945	88	26	vascular	vascular	ADJ
biomedich-945	88	27	congestion	congestion	NOUN
biomedich-945	88	28	,	,	PUNCT
biomedich-945	88	29	necrosis	necrosis	NOUN
biomedich-945	88	30	,	,	PUNCT
biomedich-945	88	31	and	and	CCONJ
biomedich-945	88	32	elevated	elevate	VERB
biomedich-945	88	33	tnf	tnf	PROPN
biomedich-945	88	34	-	-	PUNCT
biomedich-945	88	35	α	α	NOUN
biomedich-945	88	36	expression	expression	NOUN
biomedich-945	88	37	.	.	PUNCT
biomedich-945	89	1	these	these	DET
biomedich-945	89	2	histopathological	histopathological	ADJ
biomedich-945	89	3	changes	change	NOUN
biomedich-945	89	4	mirror	mirror	VERB
biomedich-945	89	5	the	the	DET
biomedich-945	89	6	patterns	pattern	NOUN
biomedich-945	89	7	we	we	PRON
biomedich-945	89	8	observed	observe	VERB
biomedich-945	89	9	,	,	PUNCT
biomedich-945	89	10	suggesting	suggest	VERB
biomedich-945	89	11	that	that	SCONJ
biomedich-945	89	12	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	89	13	exerts	exert	VERB
biomedich-945	89	14	direct	direct	ADJ
biomedich-945	89	15	toxic	toxic	ADJ
biomedich-945	89	16	effects	effect	NOUN
biomedich-945	89	17	on	on	ADP
biomedich-945	89	18	gastric	gastric	ADJ
biomedich-945	89	19	mucosa	mucosa	NOUN
biomedich-945	89	20	.	.	PUNCT
biomedich-945	90	1	furthermore	furthermore	ADV
biomedich-945	90	2	,	,	PUNCT
biomedich-945	90	3	horseman	horseman	NOUN
biomedich-945	90	4	et	et	PROPN
biomedich-945	90	5	al	al	PROPN
biomedich-945	90	6	.	.	PROPN
biomedich-945	90	7	(	(	PUNCT
biomedich-945	90	8	2024	2024	NUM
biomedich-945	90	9	)	)	PUNCT
biomedich-945	90	10	showed	show	VERB
biomedich-945	90	11	that	that	SCONJ
biomedich-945	90	12	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	90	13	,	,	PUNCT
biomedich-945	90	14	particularly	particularly	ADV
biomedich-945	90	15	when	when	SCONJ
biomedich-945	90	16	combined	combine	VERB
biomedich-945	90	17	with	with	ADP
biomedich-945	90	18	supportive	supportive	ADJ
biomedich-945	90	19	agents	agent	NOUN
biomedich-945	90	20	,	,	PUNCT
biomedich-945	90	21	altered	alter	VERB
biomedich-945	90	22	intestinal	intestinal	ADJ
biomedich-945	90	23	structure	structure	NOUN
biomedich-945	90	24	and	and	CCONJ
biomedich-945	90	25	microbiota	microbiota	NOUN
biomedich-945	90	26	following	follow	VERB
biomedich-945	90	27	irradiation	irradiation	NOUN
biomedich-945	90	28	in	in	ADP
biomedich-945	90	29	mice	mouse	NOUN
biomedich-945	90	30	.	.	PUNCT
biomedich-945	91	1	while	while	SCONJ
biomedich-945	91	2	that	that	DET
biomedich-945	91	3	study	study	NOUN
biomedich-945	91	4	focused	focus	VERB
biomedich-945	91	5	on	on	ADP
biomedich-945	91	6	the	the	DET
biomedich-945	91	7	intestine	intestine	NOUN
biomedich-945	91	8	,	,	PUNCT
biomedich-945	91	9	the	the	DET
biomedich-945	91	10	disruption	disruption	NOUN
biomedich-945	91	11	of	of	ADP
biomedich-945	91	12	mucosal	mucosal	ADJ
biomedich-945	91	13	architecture	architecture	NOUN
biomedich-945	91	14	and	and	CCONJ
biomedich-945	91	15	immune	immune	ADJ
biomedich-945	91	16	balance	balance	NOUN
biomedich-945	91	17	supports	support	VERB
biomedich-945	91	18	our	our	PRON
biomedich-945	91	19	observations	observation	NOUN
biomedich-945	91	20	of	of	ADP
biomedich-945	91	21	the	the	DET
biomedich-945	91	22	gastric	gastric	ADJ
biomedich-945	91	23	vulnerability	vulnerability	NOUN
biomedich-945	91	24	(	(	PUNCT
biomedich-945	91	25	horseman	horseman	NOUN
biomedich-945	91	26	et	et	PROPN
biomedich-945	91	27	al	al	PROPN
biomedich-945	91	28	.	.	PROPN
biomedich-945	91	29	,	,	PUNCT
biomedich-945	91	30	2024	2024	NUM
biomedich-945	91	31	)	)	PUNCT
biomedich-945	91	32	.	.	PUNCT
biomedich-945	92	1	the	the	DET
biomedich-945	92	2	mechanisms	mechanism	NOUN
biomedich-945	92	3	underlying	underlie	VERB
biomedich-945	92	4	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	92	5	-	-	PUNCT
biomedich-945	92	6	induced	induce	VERB
biomedich-945	92	7	mucosal	mucosal	NOUN
biomedich-945	92	8	damage	damage	NOUN
biomedich-945	92	9	are	be	AUX
biomedich-945	92	10	multifactorial	multifactorial	ADJ
biomedich-945	92	11	.	.	PUNCT
biomedich-945	93	1	evidence	evidence	NOUN
biomedich-945	93	2	suggests	suggest	VERB
biomedich-945	93	3	that	that	SCONJ
biomedich-945	93	4	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	93	5	may	may	AUX
biomedich-945	93	6	induce	induce	VERB
biomedich-945	93	7	oxidative	oxidative	ADJ
biomedich-945	93	8	stress	stress	NOUN
biomedich-945	93	9	,	,	PUNCT
biomedich-945	93	10	generating	generate	VERB
biomedich-945	93	11	reactive	reactive	ADJ
biomedich-945	93	12	oxygen	oxygen	NOUN
biomedich-945	93	13	species	specie	NOUN
biomedich-945	93	14	(	(	PUNCT
biomedich-945	93	15	ros	ros	PROPN
biomedich-945	93	16	)	)	PUNCT
biomedich-945	93	17	that	that	PRON
biomedich-945	93	18	impair	impair	VERB
biomedich-945	93	19	epithelial	epithelial	ADJ
biomedich-945	93	20	cell	cell	NOUN
biomedich-945	93	21	integrity	integrity	NOUN
biomedich-945	93	22	and	and	CCONJ
biomedich-945	93	23	trigger	trigger	NOUN
biomedich-945	93	24	inflammatory	inflammatory	ADJ
biomedich-945	93	25	cascades	cascade	NOUN
biomedich-945	93	26	(	(	PUNCT
biomedich-945	93	27	el	el	PROPN
biomedich-945	93	28	-	-	PUNCT
biomedich-945	93	29	masry	masry	PROPN
biomedich-945	93	30	et	et	PROPN
biomedich-945	93	31	al	al	PROPN
biomedich-945	93	32	.	.	PROPN
biomedich-945	93	33	,	,	PUNCT
biomedich-945	93	34	2021	2021	NUM
biomedich-945	93	35	)	)	PUNCT
biomedich-945	93	36	.	.	PUNCT
biomedich-945	94	1	ge	ge	PROPN
biomedich-945	94	2	,	,	PUNCT
biomedich-945	94	3	mao	mao	PROPN
biomedich-945	94	4	,	,	PUNCT
biomedich-945	94	5	cai	cai	PROPN
biomedich-945	94	6	,	,	PUNCT
biomedich-945	94	7	and	and	CCONJ
biomedich-945	94	8	huang	huang	PROPN
biomedich-945	94	9	(	(	PUNCT
biomedich-945	94	10	2020	2020	NUM
biomedich-945	94	11	)	)	PUNCT
biomedich-945	94	12	demonstrated	demonstrate	VERB
biomedich-945	94	13	that	that	SCONJ
biomedich-945	94	14	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	94	15	impaired	impair	VERB
biomedich-945	94	16	gut	gut	NOUN
biomedich-945	94	17	barrier	barrier	NOUN
biomedich-945	94	18	integrity	integrity	NOUN
biomedich-945	94	19	in	in	ADP
biomedich-945	94	20	mice	mouse	NOUN
biomedich-945	94	21	by	by	ADP
biomedich-945	94	22	reducing	reduce	VERB
biomedich-945	94	23	tight	tight	ADJ
biomedich-945	94	24	junction	junction	NOUN
biomedich-945	94	25	proteins	protein	NOUN
biomedich-945	94	26	(	(	PUNCT
biomedich-945	94	27	zo-1	zo-1	NUM
biomedich-945	94	28	and	and	CCONJ
biomedich-945	94	29	occludin	occludin	NUM
biomedich-945	94	30	)	)	PUNCT
biomedich-945	94	31	,	,	PUNCT
biomedich-945	94	32	increasing	increase	VERB
biomedich-945	94	33	il-1β	il-1β	ADJ
biomedich-945	94	34	expression	expression	NOUN
biomedich-945	94	35	,	,	PUNCT
biomedich-945	94	36	and	and	CCONJ
biomedich-945	94	37	promoting	promote	VERB
biomedich-945	94	38	epithelial	epithelial	ADJ
biomedich-945	94	39	apoptosis	apoptosis	NOUN
biomedich-945	94	40	.	.	PUNCT
biomedich-945	95	1	these	these	DET
biomedich-945	95	2	mechanisms	mechanism	NOUN
biomedich-945	95	3	,	,	PUNCT
biomedich-945	95	4	although	although	SCONJ
biomedich-945	95	5	observed	observe	VERB
biomedich-945	95	6	in	in	ADP
biomedich-945	95	7	the	the	DET
biomedich-945	95	8	intestine	intestine	NOUN
biomedich-945	95	9	,	,	PUNCT
biomedich-945	95	10	are	be	AUX
biomedich-945	95	11	likely	likely	ADV
biomedich-945	95	12	relevant	relevant	ADJ
biomedich-945	95	13	to	to	ADP
biomedich-945	95	14	gastric	gastric	ADJ
biomedich-945	95	15	mucosa	mucosa	NOUN
biomedich-945	95	16	as	as	ADV
biomedich-945	95	17	well	well	ADV
biomedich-945	95	18	(	(	PUNCT
biomedich-945	95	19	ibrahim	ibrahim	NOUN
biomedich-945	95	20	et	et	PROPN
biomedich-945	95	21	al	al	PROPN
biomedich-945	95	22	.	.	PROPN
biomedich-945	95	23	,	,	PUNCT
biomedich-945	95	24	2021	2021	NUM
biomedich-945	95	25	;	;	PUNCT
biomedich-945	95	26	çulpan	çulpan	NOUN
biomedich-945	95	27	,	,	PUNCT
biomedich-945	95	28	2022	2022	NUM
biomedich-945	95	29	)	)	PUNCT
biomedich-945	95	30	.	.	PUNCT
biomedich-945	96	1	another	another	DET
biomedich-945	96	2	contributing	contribute	VERB
biomedich-945	96	3	factor	factor	NOUN
biomedich-945	96	4	may	may	AUX
biomedich-945	96	5	be	be	AUX
biomedich-945	96	6	antibiotic	antibiotic	ADJ
biomedich-945	96	7	-	-	PUNCT
biomedich-945	96	8	induced	induce	VERB
biomedich-945	96	9	dysbiosis	dysbiosis	NOUN
biomedich-945	96	10	.	.	PUNCT
biomedich-945	97	1	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	97	2	has	have	AUX
biomedich-945	97	3	been	be	AUX
biomedich-945	97	4	shown	show	VERB
biomedich-945	97	5	to	to	PART
biomedich-945	97	6	disrupt	disrupt	VERB
biomedich-945	97	7	microbial	microbial	ADJ
biomedich-945	97	8	diversity	diversity	NOUN
biomedich-945	97	9	and	and	CCONJ
biomedich-945	97	10	host	host	NOUN
biomedich-945	97	11	–	–	PUNCT
biomedich-945	97	12	microbiota	microbiota	NOUN
biomedich-945	97	13	interactions	interaction	NOUN
biomedich-945	97	14	(	(	PUNCT
biomedich-945	97	15	ge	ge	PROPN
biomedich-945	97	16	et	et	PROPN
biomedich-945	97	17	al	al	PROPN
biomedich-945	97	18	.	.	PROPN
biomedich-945	97	19	,	,	PUNCT
biomedich-945	97	20	2020	2020	NUM
biomedich-945	97	21	)	)	PUNCT
biomedich-945	97	22	,	,	PUNCT
biomedich-945	97	23	which	which	PRON
biomedich-945	97	24	can	can	AUX
biomedich-945	97	25	compromise	compromise	VERB
biomedich-945	97	26	mucosal	mucosal	NOUN
biomedich-945	97	27	defense	defense	NOUN
biomedich-945	97	28	and	and	CCONJ
biomedich-945	97	29	immune	immune	ADJ
biomedich-945	97	30	regulation	regulation	NOUN
biomedich-945	97	31	.	.	PUNCT
biomedich-945	98	1	disruption	disruption	NOUN
biomedich-945	98	2	of	of	ADP
biomedich-945	98	3	gastric	gastric	ADJ
biomedich-945	98	4	or	or	CCONJ
biomedich-945	98	5	intestinal	intestinal	ADJ
biomedich-945	98	6	microbiota	microbiota	NOUN
biomedich-945	98	7	may	may	AUX
biomedich-945	98	8	thus	thus	ADV
biomedich-945	98	9	predispose	predispose	VERB
biomedich-945	98	10	to	to	ADP
biomedich-945	98	11	mucosal	mucosal	ADJ
biomedich-945	98	12	injury	injury	NOUN
biomedich-945	98	13	(	(	PUNCT
biomedich-945	98	14	xie	xie	PROPN
biomedich-945	98	15	et	et	PROPN
biomedich-945	98	16	al	al	PROPN
biomedich-945	98	17	.	.	PROPN
biomedich-945	98	18	,	,	PUNCT
biomedich-945	98	19	2024	2024	NUM
biomedich-945	98	20	)	)	PUNCT
biomedich-945	98	21	.	.	PUNCT
biomedich-945	99	1	additionally	additionally	ADV
biomedich-945	99	2	,	,	PUNCT
biomedich-945	99	3	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	99	4	are	be	AUX
biomedich-945	99	5	known	know	VERB
biomedich-945	99	6	to	to	PART
biomedich-945	99	7	interfere	interfere	VERB
biomedich-945	99	8	with	with	ADP
biomedich-945	99	9	collagen	collagen	NOUN
biomedich-945	99	10	metabolism	metabolism	NOUN
biomedich-945	99	11	,	,	PUNCT
biomedich-945	99	12	a	a	DET
biomedich-945	99	13	condition	condition	NOUN
biomedich-945	99	14	associated	associate	VERB
biomedich-945	99	15	with	with	ADP
biomedich-945	99	16	tendon	tendon	NOUN
biomedich-945	99	17	rupture	rupture	NOUN
biomedich-945	99	18	and	and	CCONJ
biomedich-945	99	19	vascular	vascular	ADJ
biomedich-945	99	20	complications	complication	NOUN
biomedich-945	99	21	(	(	PUNCT
biomedich-945	99	22	u.s	u.s	PROPN
biomedich-945	99	23	.	.	PROPN
biomedich-945	99	24	food	food	PROPN
biomedich-945	99	25	and	and	CCONJ
biomedich-945	99	26	drug	drug	NOUN
biomedich-945	99	27	administration	administration	NOUN
biomedich-945	99	28	,	,	PUNCT
biomedich-945	99	29	2018	2018	NUM
biomedich-945	99	30	)	)	PUNCT
biomedich-945	99	31	.	.	PUNCT
biomedich-945	100	1	weakening	weaken	VERB
biomedich-945	100	2	of	of	ADP
biomedich-945	100	3	collagenous	collagenous	ADJ
biomedich-945	100	4	structures	structure	NOUN
biomedich-945	100	5	within	within	ADP
biomedich-945	100	6	the	the	DET
biomedich-945	100	7	gastric	gastric	ADJ
biomedich-945	100	8	wall	wall	NOUN
biomedich-945	100	9	may	may	AUX
biomedich-945	100	10	contribute	contribute	VERB
biomedich-945	100	11	to	to	ADP
biomedich-945	100	12	mucosal	mucosal	NOUN
biomedich-945	100	13	thinning	thinning	NOUN
biomedich-945	100	14	and	and	CCONJ
biomedich-945	100	15	,	,	PUNCT
biomedich-945	100	16	in	in	ADP
biomedich-945	100	17	severe	severe	ADJ
biomedich-945	100	18	cases	case	NOUN
biomedich-945	100	19	,	,	PUNCT
biomedich-945	100	20	gastrointestinal	gastrointestinal	ADJ
biomedich-945	100	21	perforation	perforation	NOUN
biomedich-945	100	22	(	(	PUNCT
biomedich-945	100	23	wang	wang	PROPN
biomedich-945	100	24	et	et	PROPN
biomedich-945	100	25	al	al	PROPN
biomedich-945	100	26	.	.	PROPN
biomedich-945	100	27	,	,	PUNCT
biomedich-945	100	28	2023	2023	NUM
biomedich-945	100	29	)	)	PUNCT
biomedich-945	100	30	.	.	PUNCT
biomedich-945	101	1	from	from	ADP
biomedich-945	101	2	a	a	DET
biomedich-945	101	3	clinical	clinical	ADJ
biomedich-945	101	4	standpoint	standpoint	NOUN
biomedich-945	101	5	,	,	PUNCT
biomedich-945	101	6	these	these	DET
biomedich-945	101	7	findings	finding	NOUN
biomedich-945	101	8	have	have	VERB
biomedich-945	101	9	important	important	ADJ
biomedich-945	101	10	implications	implication	NOUN
biomedich-945	101	11	(	(	PUNCT
biomedich-945	101	12	mojoyinola	mojoyinola	PROPN
biomedich-945	101	13	&	&	CCONJ
biomedich-945	101	14	ogundipe	ogundipe	PROPN
biomedich-945	101	15	,	,	PUNCT
biomedich-945	101	16	2023	2023	NUM
biomedich-945	101	17	)	)	PUNCT
biomedich-945	101	18	.	.	PUNCT
biomedich-945	102	1	drug	drug	NOUN
biomedich-945	102	2	-	-	PUNCT
biomedich-945	102	3	induced	induce	VERB
biomedich-945	102	4	gastric	gastric	ADJ
biomedich-945	102	5	injury	injury	NOUN
biomedich-945	102	6	remains	remain	VERB
biomedich-945	102	7	a	a	DET
biomedich-945	102	8	recognized	recognize	VERB
biomedich-945	102	9	adverse	adverse	ADJ
biomedich-945	102	10	effect	effect	NOUN
biomedich-945	102	11	of	of	ADP
biomedich-945	102	12	several	several	ADJ
biomedich-945	102	13	medication	medication	NOUN
biomedich-945	102	14	classes	class	NOUN
biomedich-945	102	15	,	,	PUNCT
biomedich-945	102	16	including	include	VERB
biomedich-945	102	17	nsaids	nsaid	NOUN
biomedich-945	102	18	,	,	PUNCT
biomedich-945	102	19	corticosteroids	corticosteroid	NOUN
biomedich-945	102	20	,	,	PUNCT
biomedich-945	102	21	and	and	CCONJ
biomedich-945	102	22	antibiotics	antibiotic	NOUN
biomedich-945	102	23	(	(	PUNCT
biomedich-945	102	24	arafat	arafat	PROPN
biomedich-945	102	25	et	et	PROPN
biomedich-945	102	26	al	al	PROPN
biomedich-945	102	27	.	.	PROPN
biomedich-945	102	28	,	,	PUNCT
biomedich-945	102	29	2021	2021	NUM
biomedich-945	102	30	;	;	PUNCT
biomedich-945	102	31	nawaz	nawaz	NOUN
biomedich-945	102	32	,	,	PUNCT
biomedich-945	102	33	2021	2021	NUM
biomedich-945	102	34	)	)	PUNCT
biomedich-945	102	35	.	.	PUNCT
biomedich-945	103	1	a	a	DET
biomedich-945	103	2	recent	recent	ADJ
biomedich-945	103	3	review	review	NOUN
biomedich-945	103	4	highlighted	highlight	VERB
biomedich-945	103	5	that	that	SCONJ
biomedich-945	103	6	antibiotics	antibiotic	NOUN
biomedich-945	103	7	such	such	ADJ
biomedich-945	103	8	as	as	ADP
biomedich-945	103	9	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	103	10	can	can	AUX
biomedich-945	103	11	cause	cause	VERB
biomedich-945	103	12	distinct	distinct	ADJ
biomedich-945	103	13	a	a	DET
biomedich-945	103	14	b	b	NOUN
biomedich-945	103	15	c	c	PROPN
biomedich-945	103	16	d	d	X
biomedich-945	103	17	savitri	savitri	PROPN
biomedich-945	103	18	et	et	PROPN
biomedich-945	103	19	al	al	PROPN
biomedich-945	103	20	.	.	PROPN
biomedich-945	103	21	–	–	PUNCT
biomedich-945	103	22	effect	effect	NOUN
biomedich-945	103	23	of	of	ADP
biomedich-945	103	24	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	103	25	administration	administration	NOUN
biomedich-945	103	26	on	on	ADP
biomedich-945	103	27	gastric	gastric	ADJ
biomedich-945	103	28	histopathological	histopathological	ADJ
biomedich-945	103	29	…	…	PUNCT
biomedich-945	103	30	877	877	NUM
biomedich-945	103	31	gastric	gastric	ADJ
biomedich-945	103	32	lesions	lesion	NOUN
biomedich-945	103	33	characterized	characterize	VERB
biomedich-945	103	34	by	by	ADP
biomedich-945	103	35	erosion	erosion	NOUN
biomedich-945	103	36	,	,	PUNCT
biomedich-945	103	37	ulceration	ulceration	NOUN
biomedich-945	103	38	,	,	PUNCT
biomedich-945	103	39	and	and	CCONJ
biomedich-945	103	40	inflammatory	inflammatory	ADJ
biomedich-945	103	41	cell	cell	NOUN
biomedich-945	103	42	infiltration	infiltration	NOUN
biomedich-945	103	43	(	(	PUNCT
biomedich-945	103	44	liu	liu	PROPN
biomedich-945	103	45	et	et	PROPN
biomedich-945	103	46	al	al	PROPN
biomedich-945	103	47	.	.	PROPN
biomedich-945	103	48	,	,	PUNCT
biomedich-945	103	49	2025	2025	NUM
biomedich-945	103	50	;	;	PUNCT
biomedich-945	103	51	zhu	zhu	PROPN
biomedich-945	103	52	,	,	PUNCT
biomedich-945	103	53	2020	2020	NUM
biomedich-945	103	54	)	)	PUNCT
biomedich-945	103	55	.	.	PUNCT
biomedich-945	104	1	given	give	VERB
biomedich-945	104	2	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	104	3	’s	’s	PART
biomedich-945	104	4	widespread	widespread	ADJ
biomedich-945	104	5	use	use	NOUN
biomedich-945	104	6	in	in	ADP
biomedich-945	104	7	human	human	ADJ
biomedich-945	104	8	and	and	CCONJ
biomedich-945	104	9	veterinary	veterinary	ADJ
biomedich-945	104	10	medicine	medicine	NOUN
biomedich-945	104	11	,	,	PUNCT
biomedich-945	104	12	the	the	DET
biomedich-945	104	13	potential	potential	NOUN
biomedich-945	104	14	for	for	ADP
biomedich-945	104	15	gastric	gastric	ADJ
biomedich-945	104	16	toxicity	toxicity	NOUN
biomedich-945	104	17	warrants	warrant	NOUN
biomedich-945	104	18	closer	close	ADJ
biomedich-945	104	19	evaluation	evaluation	NOUN
biomedich-945	104	20	.	.	PUNCT
biomedich-945	105	1	patients	patient	NOUN
biomedich-945	105	2	with	with	ADP
biomedich-945	105	3	pre	pre	ADJ
biomedich-945	105	4	-	-	ADJ
biomedich-945	105	5	existing	exist	VERB
biomedich-945	105	6	gastrointestinal	gastrointestinal	ADJ
biomedich-945	105	7	conditions	condition	NOUN
biomedich-945	105	8	,	,	PUNCT
biomedich-945	105	9	prolonged	prolonged	ADJ
biomedich-945	105	10	therapy	therapy	NOUN
biomedich-945	105	11	,	,	PUNCT
biomedich-945	105	12	or	or	CCONJ
biomedich-945	105	13	concomitant	concomitant	ADJ
biomedich-945	105	14	use	use	NOUN
biomedich-945	105	15	of	of	ADP
biomedich-945	105	16	other	other	ADJ
biomedich-945	105	17	mucosa	mucosa	NOUN
biomedich-945	105	18	-	-	PUNCT
biomedich-945	105	19	damaging	damage	VERB
biomedich-945	105	20	drugs	drug	NOUN
biomedich-945	105	21	may	may	AUX
biomedich-945	105	22	be	be	AUX
biomedich-945	105	23	particularly	particularly	ADV
biomedich-945	105	24	vulnerable	vulnerable	ADJ
biomedich-945	105	25	(	(	PUNCT
biomedich-945	105	26	liu	liu	PROPN
biomedich-945	105	27	et	et	PROPN
biomedich-945	105	28	al	al	PROPN
biomedich-945	105	29	.	.	PROPN
biomedich-945	105	30	,	,	PUNCT
biomedich-945	105	31	2024	2024	NUM
biomedich-945	105	32	)	)	PUNCT
biomedich-945	105	33	.	.	PUNCT
biomedich-945	106	1	our	our	PRON
biomedich-945	106	2	study	study	NOUN
biomedich-945	106	3	also	also	ADV
biomedich-945	106	4	emphasizes	emphasize	VERB
biomedich-945	106	5	the	the	DET
biomedich-945	106	6	utility	utility	NOUN
biomedich-945	106	7	of	of	ADP
biomedich-945	106	8	mice	mouse	NOUN
biomedich-945	106	9	as	as	ADP
biomedich-945	106	10	an	an	DET
biomedich-945	106	11	experimental	experimental	ADJ
biomedich-945	106	12	model	model	NOUN
biomedich-945	106	13	.	.	PUNCT
biomedich-945	107	1	their	their	PRON
biomedich-945	107	2	genetic	genetic	ADJ
biomedich-945	107	3	similarity	similarity	NOUN
biomedich-945	107	4	to	to	ADP
biomedich-945	107	5	humans	human	NOUN
biomedich-945	107	6	and	and	CCONJ
biomedich-945	107	7	controlled	control	VERB
biomedich-945	107	8	environment	environment	NOUN
biomedich-945	107	9	make	make	VERB
biomedich-945	107	10	them	they	PRON
biomedich-945	107	11	suitable	suitable	ADJ
biomedich-945	107	12	for	for	ADP
biomedich-945	107	13	preclinical	preclinical	ADJ
biomedich-945	107	14	toxicology	toxicology	NOUN
biomedich-945	107	15	.	.	PUNCT
biomedich-945	108	1	the	the	DET
biomedich-945	108	2	dose	dose	NOUN
biomedich-945	108	3	-	-	PUNCT
biomedich-945	108	4	dependent	dependent	ADJ
biomedich-945	108	5	progression	progression	NOUN
biomedich-945	108	6	observed	observe	VERB
biomedich-945	108	7	here	here	ADV
biomedich-945	108	8	provides	provide	VERB
biomedich-945	108	9	a	a	DET
biomedich-945	108	10	framework	framework	NOUN
biomedich-945	108	11	for	for	ADP
biomedich-945	108	12	future	future	ADJ
biomedich-945	108	13	studies	study	NOUN
biomedich-945	108	14	exploring	explore	VERB
biomedich-945	108	15	protective	protective	ADJ
biomedich-945	108	16	strategies	strategy	NOUN
biomedich-945	108	17	,	,	PUNCT
biomedich-945	108	18	such	such	ADJ
biomedich-945	108	19	as	as	ADP
biomedich-945	108	20	antioxidants	antioxidant	NOUN
biomedich-945	108	21	,	,	PUNCT
biomedich-945	108	22	probiotics	probiotic	NOUN
biomedich-945	108	23	,	,	PUNCT
biomedich-945	108	24	or	or	CCONJ
biomedich-945	108	25	proton	proton	NOUN
biomedich-945	108	26	pump	pump	NOUN
biomedich-945	108	27	inhibitors	inhibitor	NOUN
biomedich-945	108	28	.	.	PUNCT
biomedich-945	109	1	this	this	DET
biomedich-945	109	2	study	study	NOUN
biomedich-945	109	3	has	have	VERB
biomedich-945	109	4	several	several	ADJ
biomedich-945	109	5	limitations	limitation	NOUN
biomedich-945	109	6	.	.	PUNCT
biomedich-945	110	1	first	first	ADV
biomedich-945	110	2	,	,	PUNCT
biomedich-945	110	3	the	the	DET
biomedich-945	110	4	treatment	treatment	NOUN
biomedich-945	110	5	period	period	NOUN
biomedich-945	110	6	was	be	AUX
biomedich-945	110	7	limited	limit	VERB
biomedich-945	110	8	to	to	ADP
biomedich-945	110	9	14	14	NUM
biomedich-945	110	10	days	day	NOUN
biomedich-945	110	11	;	;	PUNCT
biomedich-945	110	12	longer	long	ADJ
biomedich-945	110	13	exposure	exposure	NOUN
biomedich-945	110	14	might	might	AUX
biomedich-945	110	15	reveal	reveal	VERB
biomedich-945	110	16	cumulative	cumulative	ADJ
biomedich-945	110	17	or	or	CCONJ
biomedich-945	110	18	chronic	chronic	ADJ
biomedich-945	110	19	effects	effect	NOUN
biomedich-945	110	20	.	.	PUNCT
biomedich-945	111	1	second	second	ADJ
biomedich-945	111	2	,	,	PUNCT
biomedich-945	111	3	we	we	PRON
biomedich-945	111	4	focused	focus	VERB
biomedich-945	111	5	exclusively	exclusively	ADV
biomedich-945	111	6	on	on	ADP
biomedich-945	111	7	histopathology	histopathology	NOUN
biomedich-945	111	8	,	,	PUNCT
biomedich-945	111	9	without	without	ADP
biomedich-945	111	10	assessing	assess	VERB
biomedich-945	111	11	biochemical	biochemical	ADJ
biomedich-945	111	12	markers	marker	NOUN
biomedich-945	111	13	such	such	ADJ
biomedich-945	111	14	as	as	ADP
biomedich-945	111	15	malondialdehyde	malondialdehyde	NOUN
biomedich-945	111	16	or	or	CCONJ
biomedich-945	111	17	cytokine	cytokine	ADJ
biomedich-945	111	18	levels	level	NOUN
biomedich-945	111	19	that	that	PRON
biomedich-945	111	20	could	could	AUX
biomedich-945	111	21	clarify	clarify	VERB
biomedich-945	111	22	molecular	molecular	ADJ
biomedich-945	111	23	mechanisms	mechanism	NOUN
biomedich-945	111	24	.	.	PUNCT
biomedich-945	112	1	third	third	ADJ
biomedich-945	112	2	,	,	PUNCT
biomedich-945	112	3	we	we	PRON
biomedich-945	112	4	did	do	AUX
biomedich-945	112	5	not	not	PART
biomedich-945	112	6	analyze	analyze	VERB
biomedich-945	112	7	gastric	gastric	ADJ
biomedich-945	112	8	microbiota	microbiota	NOUN
biomedich-945	112	9	,	,	PUNCT
biomedich-945	112	10	which	which	PRON
biomedich-945	112	11	may	may	AUX
biomedich-945	112	12	mediate	mediate	VERB
biomedich-945	112	13	some	some	PRON
biomedich-945	112	14	of	of	ADP
biomedich-945	112	15	the	the	DET
biomedich-945	112	16	observed	observe	VERB
biomedich-945	112	17	effects	effect	NOUN
biomedich-945	112	18	.	.	PUNCT
biomedich-945	113	1	future	future	ADJ
biomedich-945	113	2	studies	study	NOUN
biomedich-945	113	3	should	should	AUX
biomedich-945	113	4	extend	extend	VERB
biomedich-945	113	5	treatment	treatment	NOUN
biomedich-945	113	6	duration	duration	NOUN
biomedich-945	113	7	,	,	PUNCT
biomedich-945	113	8	incorporate	incorporate	VERB
biomedich-945	113	9	biochemical	biochemical	ADJ
biomedich-945	113	10	and	and	CCONJ
biomedich-945	113	11	microbiota	microbiota	NOUN
biomedich-945	113	12	analyses	analysis	NOUN
biomedich-945	113	13	,	,	PUNCT
biomedich-945	113	14	and	and	CCONJ
biomedich-945	113	15	evaluate	evaluate	VERB
biomedich-945	113	16	potential	potential	ADJ
biomedich-945	113	17	gastroprotective	gastroprotective	NOUN
biomedich-945	113	18	interventions	intervention	NOUN
biomedich-945	113	19	(	(	PUNCT
biomedich-945	113	20	hou	hou	NOUN
biomedich-945	113	21	,	,	PUNCT
biomedich-945	113	22	2025	2025	NUM
biomedich-945	113	23	)	)	PUNCT
biomedich-945	113	24	.	.	PUNCT
biomedich-945	114	1	in	in	ADP
biomedich-945	114	2	summary	summary	NOUN
biomedich-945	114	3	,	,	PUNCT
biomedich-945	114	4	our	our	PRON
biomedich-945	114	5	findings	finding	NOUN
biomedich-945	114	6	demonstrate	demonstrate	VERB
biomedich-945	114	7	that	that	SCONJ
biomedich-945	114	8	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	114	9	administration	administration	NOUN
biomedich-945	114	10	induces	induce	VERB
biomedich-945	114	11	dose	dose	NOUN
biomedich-945	114	12	-	-	PUNCT
biomedich-945	114	13	dependent	dependent	ADJ
biomedich-945	114	14	gastric	gastric	ADJ
biomedich-945	114	15	mucosal	mucosal	NOUN
biomedich-945	114	16	injury	injury	NOUN
biomedich-945	114	17	in	in	ADP
biomedich-945	114	18	mice	mouse	NOUN
biomedich-945	114	19	,	,	PUNCT
biomedich-945	114	20	consistent	consistent	ADJ
biomedich-945	114	21	with	with	ADP
biomedich-945	114	22	previous	previous	ADJ
biomedich-945	114	23	evidence	evidence	NOUN
biomedich-945	114	24	of	of	ADP
biomedich-945	114	25	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	114	26	toxicity	toxicity	NOUN
biomedich-945	114	27	in	in	ADP
biomedich-945	114	28	gastrointestinal	gastrointestinal	ADJ
biomedich-945	114	29	tissues	tissue	NOUN
biomedich-945	114	30	.	.	PUNCT
biomedich-945	115	1	these	these	DET
biomedich-945	115	2	results	result	NOUN
biomedich-945	115	3	underscore	underscore	VERB
biomedich-945	115	4	the	the	DET
biomedich-945	115	5	importance	importance	NOUN
biomedich-945	115	6	of	of	ADP
biomedich-945	115	7	cautious	cautious	ADJ
biomedich-945	115	8	use	use	NOUN
biomedich-945	115	9	,	,	PUNCT
biomedich-945	115	10	particularly	particularly	ADV
biomedich-945	115	11	in	in	ADP
biomedich-945	115	12	prolonged	prolonged	ADJ
biomedich-945	115	13	or	or	CCONJ
biomedich-945	115	14	high	high	ADJ
biomedich-945	115	15	-	-	PUNCT
biomedich-945	115	16	dose	dose	NOUN
biomedich-945	115	17	therapy	therapy	NOUN
biomedich-945	115	18	,	,	PUNCT
biomedich-945	115	19	and	and	CCONJ
biomedich-945	115	20	highlight	highlight	VERB
biomedich-945	115	21	the	the	DET
biomedich-945	115	22	need	need	NOUN
biomedich-945	115	23	for	for	ADP
biomedich-945	115	24	preventive	preventive	ADJ
biomedich-945	115	25	measures	measure	NOUN
biomedich-945	115	26	to	to	PART
biomedich-945	115	27	mitigate	mitigate	VERB
biomedich-945	115	28	drug	drug	NOUN
biomedich-945	115	29	-	-	PUNCT
biomedich-945	115	30	induced	induce	VERB
biomedich-945	115	31	gastric	gastric	ADJ
biomedich-945	115	32	damage	damage	NOUN
biomedich-945	115	33	.	.	PUNCT
biomedich-945	116	1	conclusions	conclusion	NOUN
biomedich-945	116	2	this	this	DET
biomedich-945	116	3	study	study	NOUN
biomedich-945	116	4	demonstrated	demonstrate	VERB
biomedich-945	116	5	that	that	SCONJ
biomedich-945	116	6	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	116	7	administration	administration	NOUN
biomedich-945	116	8	induced	induce	VERB
biomedich-945	116	9	dose	dose	NOUN
biomedich-945	116	10	-	-	PUNCT
biomedich-945	116	11	dependent	dependent	ADJ
biomedich-945	116	12	gastric	gastric	ADJ
biomedich-945	116	13	mucosal	mucosal	NOUN
biomedich-945	116	14	injury	injury	NOUN
biomedich-945	116	15	in	in	ADP
biomedich-945	116	16	mice	mouse	NOUN
biomedich-945	116	17	.	.	PUNCT
biomedich-945	117	1	histopathological	histopathological	ADJ
biomedich-945	117	2	changes	change	NOUN
biomedich-945	117	3	ranged	range	VERB
biomedich-945	117	4	from	from	ADP
biomedich-945	117	5	mild	mild	ADJ
biomedich-945	117	6	epithelial	epithelial	ADJ
biomedich-945	117	7	erosion	erosion	NOUN
biomedich-945	117	8	at	at	ADP
biomedich-945	117	9	low	low	ADJ
biomedich-945	117	10	doses	dose	NOUN
biomedich-945	117	11	to	to	ADP
biomedich-945	117	12	severe	severe	ADJ
biomedich-945	117	13	ulceration	ulceration	NOUN
biomedich-945	117	14	and	and	CCONJ
biomedich-945	117	15	mucosal	mucosal	NOUN
biomedich-945	117	16	thinning	thinning	NOUN
biomedich-945	117	17	at	at	ADP
biomedich-945	117	18	high	high	ADJ
biomedich-945	117	19	doses	dose	NOUN
biomedich-945	117	20	.	.	PUNCT
biomedich-945	118	1	these	these	DET
biomedich-945	118	2	findings	finding	NOUN
biomedich-945	118	3	are	be	AUX
biomedich-945	118	4	consistent	consistent	ADJ
biomedich-945	118	5	with	with	ADP
biomedich-945	118	6	previous	previous	ADJ
biomedich-945	118	7	evidence	evidence	NOUN
biomedich-945	118	8	of	of	ADP
biomedich-945	118	9	fluoroquinoloneinduced	fluoroquinoloneinduce	VERB
biomedich-945	118	10	gastrointestinal	gastrointestinal	ADJ
biomedich-945	118	11	toxicity	toxicity	NOUN
biomedich-945	118	12	,	,	PUNCT
biomedich-945	118	13	highlighting	highlight	VERB
biomedich-945	118	14	oxidative	oxidative	ADJ
biomedich-945	118	15	stress	stress	NOUN
biomedich-945	118	16	,	,	PUNCT
biomedich-945	118	17	inflammation	inflammation	NOUN
biomedich-945	118	18	,	,	PUNCT
biomedich-945	118	19	epithelial	epithelial	ADJ
biomedich-945	118	20	barrier	barrier	NOUN
biomedich-945	118	21	disruption	disruption	NOUN
biomedich-945	118	22	,	,	PUNCT
biomedich-945	118	23	and	and	CCONJ
biomedich-945	118	24	microbiota	microbiota	NOUN
biomedich-945	118	25	imbalance	imbalance	NOUN
biomedich-945	118	26	as	as	ADP
biomedich-945	118	27	possible	possible	ADJ
biomedich-945	118	28	mechanisms	mechanism	NOUN
biomedich-945	118	29	.	.	PUNCT
biomedich-945	119	1	given	give	VERB
biomedich-945	119	2	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	119	3	’s	’s	PART
biomedich-945	119	4	wide	wide	ADJ
biomedich-945	119	5	clinical	clinical	ADJ
biomedich-945	119	6	use	use	NOUN
biomedich-945	119	7	,	,	PUNCT
biomedich-945	119	8	the	the	DET
biomedich-945	119	9	results	result	NOUN
biomedich-945	119	10	emphasize	emphasize	VERB
biomedich-945	119	11	the	the	DET
biomedich-945	119	12	need	need	NOUN
biomedich-945	119	13	for	for	ADP
biomedich-945	119	14	cautious	cautious	ADJ
biomedich-945	119	15	prescription	prescription	NOUN
biomedich-945	119	16	,	,	PUNCT
biomedich-945	119	17	particularly	particularly	ADV
biomedich-945	119	18	for	for	ADP
biomedich-945	119	19	prolonged	prolonged	ADJ
biomedich-945	119	20	or	or	CCONJ
biomedich-945	119	21	high	high	ADJ
biomedich-945	119	22	-	-	PUNCT
biomedich-945	119	23	dose	dose	NOUN
biomedich-945	119	24	therapy	therapy	NOUN
biomedich-945	119	25	,	,	PUNCT
biomedich-945	119	26	and	and	CCONJ
biomedich-945	119	27	the	the	DET
biomedich-945	119	28	importance	importance	NOUN
biomedich-945	119	29	of	of	ADP
biomedich-945	119	30	monitoring	monitor	VERB
biomedich-945	119	31	patients	patient	NOUN
biomedich-945	119	32	with	with	ADP
biomedich-945	119	33	pre	pre	ADJ
biomedich-945	119	34	-	-	ADJ
biomedich-945	119	35	existing	exist	VERB
biomedich-945	119	36	gastric	gastric	ADJ
biomedich-945	119	37	conditions	condition	NOUN
biomedich-945	119	38	.	.	PUNCT
biomedich-945	120	1	future	future	ADJ
biomedich-945	120	2	studies	study	NOUN
biomedich-945	120	3	should	should	AUX
biomedich-945	120	4	evaluate	evaluate	VERB
biomedich-945	120	5	biochemical	biochemical	ADJ
biomedich-945	120	6	markers	marker	NOUN
biomedich-945	120	7	,	,	PUNCT
biomedich-945	120	8	microbiota	microbiota	NOUN
biomedich-945	120	9	changes	change	NOUN
biomedich-945	120	10	,	,	PUNCT
biomedich-945	120	11	and	and	CCONJ
biomedich-945	120	12	potential	potential	ADJ
biomedich-945	120	13	gastroprotective	gastroprotective	NOUN
biomedich-945	120	14	interventions	intervention	NOUN
biomedich-945	120	15	to	to	PART
biomedich-945	120	16	understand	understand	VERB
biomedich-945	120	17	better	well	ADV
biomedich-945	120	18	and	and	CCONJ
biomedich-945	120	19	mitigate	mitigate	VERB
biomedich-945	120	20	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	120	21	-	-	PUNCT
biomedich-945	120	22	induced	induce	VERB
biomedich-945	120	23	gastric	gastric	ADJ
biomedich-945	120	24	injury	injury	NOUN
biomedich-945	120	25	.	.	PUNCT
biomedich-945	121	1	acknowledgements	acknowledgement	NOUN
biomedich-945	121	2	:	:	PUNCT
biomedich-945	121	3	the	the	DET
biomedich-945	121	4	authors	author	NOUN
biomedich-945	121	5	would	would	AUX
biomedich-945	121	6	like	like	VERB
biomedich-945	121	7	to	to	PART
biomedich-945	121	8	thank	thank	VERB
biomedich-945	121	9	the	the	DET
biomedich-945	121	10	laboratory	laboratory	NOUN
biomedich-945	121	11	of	of	ADP
biomedich-945	121	12	pathology	pathology	PROPN
biomedich-945	121	13	,	,	PUNCT
biomedich-945	121	14	faculty	faculty	NOUN
biomedich-945	121	15	of	of	ADP
biomedich-945	121	16	medicine	medicine	NOUN
biomedich-945	121	17	,	,	PUNCT
biomedich-945	121	18	brawijaya	brawijaya	NOUN
biomedich-945	121	19	university	university	NOUN
biomedich-945	121	20	,	,	PUNCT
biomedich-945	121	21	for	for	ADP
biomedich-945	121	22	technical	technical	ADJ
biomedich-945	121	23	support	support	NOUN
biomedich-945	121	24	and	and	CCONJ
biomedich-945	121	25	facilities	facility	NOUN
biomedich-945	121	26	.	.	PUNCT
biomedich-945	122	1	we	we	PRON
biomedich-945	122	2	also	also	ADV
biomedich-945	122	3	appreciate	appreciate	VERB
biomedich-945	122	4	the	the	DET
biomedich-945	122	5	contributions	contribution	NOUN
biomedich-945	122	6	of	of	ADP
biomedich-945	122	7	colleagues	colleague	NOUN
biomedich-945	122	8	who	who	PRON
biomedich-945	122	9	provided	provide	VERB
biomedich-945	122	10	valuable	valuable	ADJ
biomedich-945	122	11	input	input	NOUN
biomedich-945	122	12	during	during	ADP
biomedich-945	122	13	the	the	DET
biomedich-945	122	14	preparation	preparation	NOUN
biomedich-945	122	15	of	of	ADP
biomedich-945	122	16	this	this	DET
biomedich-945	122	17	manuscript	manuscript	NOUN
biomedich-945	122	18	.	.	PUNCT
biomedich-945	123	1	authors	author	NOUN
biomedich-945	123	2	’	'	PUNCT
biomedich-945	123	3	contributions	contribution	NOUN
biomedich-945	123	4	:	:	PUNCT
biomedich-945	123	5	lisa	lisa	PROPN
biomedich-945	123	6	savitri	savitri	PROPN
biomedich-945	123	7	designed	design	VERB
biomedich-945	123	8	the	the	DET
biomedich-945	123	9	study	study	NOUN
biomedich-945	123	10	,	,	PUNCT
biomedich-945	123	11	analyzed	analyze	VERB
biomedich-945	123	12	the	the	DET
biomedich-945	123	13	data	datum	NOUN
biomedich-945	123	14	,	,	PUNCT
biomedich-945	123	15	and	and	CCONJ
biomedich-945	123	16	wrote	write	VERB
biomedich-945	123	17	the	the	DET
biomedich-945	123	18	manuscript	manuscript	NOUN
biomedich-945	123	19	.	.	PUNCT
biomedich-945	124	1	all	all	DET
biomedich-945	124	2	authors	author	NOUN
biomedich-945	124	3	read	read	VERB
biomedich-945	124	4	and	and	CCONJ
biomedich-945	124	5	approved	approve	VERB
biomedich-945	124	6	the	the	DET
biomedich-945	124	7	final	final	ADJ
biomedich-945	124	8	version	version	NOUN
biomedich-945	124	9	of	of	ADP
biomedich-945	124	10	the	the	DET
biomedich-945	124	11	manuscript	manuscript	NOUN
biomedich-945	124	12	.	.	PUNCT
biomedich-945	125	1	competing	compete	VERB
biomedich-945	125	2	interests	interest	NOUN
biomedich-945	125	3	:	:	PUNCT
biomedich-945	125	4	the	the	DET
biomedich-945	125	5	authors	author	NOUN
biomedich-945	125	6	declare	declare	VERB
biomedich-945	125	7	that	that	SCONJ
biomedich-945	125	8	there	there	PRON
biomedich-945	125	9	are	be	VERB
biomedich-945	125	10	no	no	DET
biomedich-945	125	11	competing	compete	VERB
biomedich-945	125	12	interests	interest	NOUN
biomedich-945	125	13	.	.	PUNCT
biomedich-945	126	1	funding	funding	NOUN
biomedich-945	126	2	:	:	PUNCT
biomedich-945	126	3	the	the	DET
biomedich-945	126	4	authors	author	NOUN
biomedich-945	126	5	declare	declare	VERB
biomedich-945	126	6	that	that	SCONJ
biomedich-945	126	7	there	there	PRON
biomedich-945	126	8	are	be	VERB
biomedich-945	126	9	no	no	DET
biomedich-945	126	10	funding	funding	NOUN
biomedich-945	126	11	.	.	PUNCT
biomedich-945	127	1	references	reference	NOUN
biomedich-945	127	2	arafat	arafat	PROPN
biomedich-945	127	3	,	,	PUNCT
biomedich-945	127	4	m.	m.	NOUN
biomedich-945	127	5	t.	t.	PROPN
biomedich-945	127	6	,	,	PUNCT
biomedich-945	127	7	tronci	tronci	PROPN
biomedich-945	127	8	,	,	PUNCT
biomedich-945	127	9	g.	g.	NOUN
biomedich-945	127	10	,	,	PUNCT
biomedich-945	127	11	wood	wood	PROPN
biomedich-945	127	12	,	,	PUNCT
biomedich-945	127	13	d.	d.	PROPN
biomedich-945	127	14	j.	j.	PROPN
biomedich-945	127	15	,	,	PUNCT
biomedich-945	127	16	&	&	CCONJ
biomedich-945	127	17	russell	russell	PROPN
biomedich-945	127	18	,	,	PUNCT
biomedich-945	127	19	s.	s.	PROPN
biomedich-945	127	20	j.	j.	PROPN
biomedich-945	127	21	(	(	PUNCT
biomedich-945	127	22	2021	2021	NUM
biomedich-945	127	23	)	)	PUNCT
biomedich-945	127	24	.	.	PUNCT
biomedich-945	128	1	insitu	insitu	ADJ
biomedich-945	128	2	crosslinked	crosslinke	VERB
biomedich-945	128	3	wet	wet	ADJ
biomedich-945	128	4	-	-	PUNCT
biomedich-945	128	5	spun	spin	VERB
biomedich-945	128	6	collagen	collagen	NOUN
biomedich-945	128	7	triple	triple	ADJ
biomedich-945	128	8	helices	helix	NOUN
biomedich-945	128	9	with	with	ADP
biomedich-945	128	10	nanoscale	nanoscale	NOUN
biomedich-945	128	11	-	-	PUNCT
biomedich-945	128	12	regulated	regulate	VERB
biomedich-945	128	13	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	128	14	release	release	NOUN
biomedich-945	128	15	capability	capability	NOUN
biomedich-945	128	16	.	.	PUNCT
biomedich-945	129	1	colloids	colloid	NOUN
biomedich-945	129	2	and	and	CCONJ
biomedich-945	129	3	surfaces	surface	NOUN
biomedich-945	129	4	b	b	X
biomedich-945	129	5	:	:	PUNCT
biomedich-945	129	6	biointerfaces	biointerface	NOUN
biomedich-945	129	7	,	,	PUNCT
biomedich-945	129	8	198	198	NUM
biomedich-945	129	9	,	,	PUNCT
biomedich-945	129	10	111472	111472	NUM
biomedich-945	129	11	.	.	PUNCT
biomedich-945	130	1	https://doi.org/10.1016/j.colsurfb.2020.111472	https://doi.org/10.1016/j.colsurfb.2020.111472	PROPN
biomedich-945	130	2	çulpan	çulpan	PROPN
biomedich-945	130	3	,	,	PUNCT
biomedich-945	130	4	y.	y.	PROPN
biomedich-945	130	5	(	(	PUNCT
biomedich-945	130	6	2022	2022	NUM
biomedich-945	130	7	)	)	PUNCT
biomedich-945	130	8	.	.	PUNCT
biomedich-945	131	1	duration	duration	NOUN
biomedich-945	131	2	of	of	ADP
biomedich-945	131	3	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	131	4	use	use	NOUN
biomedich-945	131	5	is	be	AUX
biomedich-945	131	6	important	important	ADJ
biomedich-945	131	7	in	in	ADP
biomedich-945	131	8	vascular	vascular	ADJ
biomedich-945	131	9	toxicity	toxicity	NOUN
biomedich-945	131	10	:	:	PUNCT
biomedich-945	131	11	evidence	evidence	NOUN
biomedich-945	131	12	from	from	ADP
biomedich-945	131	13	aortic	aortic	ADJ
biomedich-945	131	14	wall	wall	PROPN
biomedich-945	131	15	studies	studies	PROPN
biomedich-945	131	16	.	.	PUNCT
biomedich-945	132	1	clinical	clinical	ADJ
biomedich-945	132	2	medicine	medicine	NOUN
biomedich-945	132	3	insights	insight	NOUN
biomedich-945	132	4	:	:	PUNCT
biomedich-945	132	5	cardiology	cardiology	NOUN
biomedich-945	132	6	,	,	PUNCT
biomedich-945	132	7	16	16	NUM
biomedich-945	132	8	,	,	PUNCT
biomedich-945	132	9	117954682211270	117954682211270	NUM
biomedich-945	132	10	.	.	PUNCT
biomedich-945	133	1	https://doi.org/10.1177/117954682211270	https://doi.org/10.1177/117954682211270	VERB
biomedich-945	133	2	el	el	PROPN
biomedich-945	133	3	-	-	PUNCT
biomedich-945	133	4	masry	masry	PROPN
biomedich-945	133	5	,	,	PUNCT
biomedich-945	133	6	t.	t.	PROPN
biomedich-945	133	7	a.	a.	PROPN
biomedich-945	133	8	,	,	PUNCT
biomedich-945	133	9	el	el	PROPN
biomedich-945	133	10	-	-	PUNCT
biomedich-945	133	11	baz	baz	PROPN
biomedich-945	133	12	,	,	PUNCT
biomedich-945	133	13	a.	a.	NOUN
biomedich-945	133	14	m.	m.	NOUN
biomedich-945	133	15	,	,	PUNCT
biomedich-945	133	16	&	&	CCONJ
biomedich-945	133	17	ibrahim	ibrahim	PROPN
biomedich-945	133	18	,	,	PUNCT
biomedich-945	133	19	i.	i.	PROPN
biomedich-945	133	20	a.	a.	PROPN
biomedich-945	133	21	(	(	PUNCT
biomedich-945	133	22	2021	2021	NUM
biomedich-945	133	23	)	)	PUNCT
biomedich-945	133	24	.	.	PUNCT
biomedich-945	134	1	the	the	DET
biomedich-945	134	2	impact	impact	NOUN
biomedich-945	134	3	of	of	ADP
biomedich-945	134	4	oral	oral	ADJ
biomedich-945	134	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	134	6	on	on	ADP
biomedich-945	134	7	the	the	DET
biomedich-945	134	8	structure	structure	NOUN
biomedich-945	134	9	and	and	CCONJ
biomedich-945	134	10	functions	function	NOUN
biomedich-945	134	11	of	of	ADP
biomedich-945	134	12	rat	rat	NOUN
biomedich-945	134	13	gastric	gastric	ADJ
biomedich-945	134	14	mucosa	mucosa	NOUN
biomedich-945	134	15	:	:	PUNCT
biomedich-945	134	16	histopathological	histopathological	ADJ
biomedich-945	134	17	,	,	PUNCT
biomedich-945	134	18	immunohistochemical	immunohistochemical	ADJ
biomedich-945	134	19	,	,	PUNCT
biomedich-945	134	20	and	and	CCONJ
biomedich-945	134	21	ultrastructural	ultrastructural	ADJ
biomedich-945	134	22	evaluation	evaluation	NOUN
biomedich-945	134	23	.	.	PUNCT
biomedich-945	135	1	environmental	environmental	ADJ
biomedich-945	135	2	science	science	NOUN
biomedich-945	135	3	and	and	CCONJ
biomedich-945	135	4	pollution	pollution	NOUN
biomedich-945	135	5	research	research	NOUN
biomedich-945	135	6	,	,	PUNCT
biomedich-945	135	7	28(20	28(20	NUM
biomedich-945	135	8	)	)	PUNCT
biomedich-945	135	9	,	,	PUNCT
biomedich-945	135	10	25467–25478	25467–25478	NUM
biomedich-945	135	11	.	.	PUNCT
biomedich-945	136	1	https://doi.org/10.1007/s11356-021-14018-7	https://doi.org/10.1007/s11356-021-14018-7	PROPN
biomedich-945	136	2	ge	ge	PROPN
biomedich-945	136	3	,	,	PUNCT
biomedich-945	136	4	x.	x.	PROPN
biomedich-945	136	5	,	,	PUNCT
biomedich-945	136	6	mao	mao	PROPN
biomedich-945	136	7	,	,	PUNCT
biomedich-945	136	8	q.	q.	PROPN
biomedich-945	136	9	,	,	PUNCT
biomedich-945	136	10	cai	cai	PROPN
biomedich-945	136	11	,	,	PUNCT
biomedich-945	136	12	z.	z.	PROPN
biomedich-945	136	13	,	,	PUNCT
biomedich-945	136	14	&	&	CCONJ
biomedich-945	136	15	huang	huang	PROPN
biomedich-945	136	16	,	,	PUNCT
biomedich-945	136	17	j.	j.	PROPN
biomedich-945	136	18	(	(	PUNCT
biomedich-945	136	19	2020	2020	NUM
biomedich-945	136	20	)	)	PUNCT
biomedich-945	136	21	.	.	PUNCT
biomedich-945	137	1	oral	oral	ADJ
biomedich-945	137	2	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	137	3	impairs	impair	VERB
biomedich-945	137	4	gut	gut	NOUN
biomedich-945	137	5	barrier	barrier	NOUN
biomedich-945	137	6	integrity	integrity	NOUN
biomedich-945	137	7	and	and	CCONJ
biomedich-945	137	8	alters	alter	VERB
biomedich-945	137	9	gut	gut	NOUN
biomedich-945	137	10	bacteria	bacteria	NOUN
biomedich-945	137	11	in	in	ADP
biomedich-945	137	12	mice	mouse	NOUN
biomedich-945	137	13	.	.	PUNCT
biomedich-945	138	1	antimicrobial	antimicrobial	ADJ
biomedich-945	138	2	agents	agent	NOUN
biomedich-945	138	3	and	and	CCONJ
biomedich-945	138	4	chemotherapy	chemotherapy	NOUN
biomedich-945	138	5	,	,	PUNCT
biomedich-945	138	6	64(5	64(5	PROPN
biomedich-945	138	7	)	)	PUNCT
biomedich-945	138	8	,	,	PUNCT
biomedich-945	138	9	e02117	e02117	NOUN
biomedich-945	138	10	-	-	SYM
biomedich-945	138	11	19	19	NUM
biomedich-945	138	12	.	.	PUNCT
biomedich-945	139	1	https://doi.org/10.1128/aac.02117-19	https://doi.org/10.1128/aac.02117-19	PRON
biomedich-945	139	2	horseman	horseman	NOUN
biomedich-945	139	3	,	,	PUNCT
biomedich-945	139	4	t.	t.	PROPN
biomedich-945	139	5	s.	s.	PROPN
biomedich-945	139	6	,	,	PUNCT
biomedich-945	139	7	frank	frank	PROPN
biomedich-945	139	8	,	,	PUNCT
biomedich-945	139	9	a.	a.	NOUN
biomedich-945	139	10	m.	m.	NOUN
biomedich-945	139	11	,	,	PUNCT
biomedich-945	139	12	cannon	cannon	NOUN
biomedich-945	139	13	,	,	PUNCT
biomedich-945	139	14	g.	g.	PROPN
biomedich-945	139	15	,	,	PUNCT
biomedich-945	139	16	hrdlickova	hrdlickova	PROPN
biomedich-945	139	17	,	,	PUNCT
biomedich-945	139	18	r.	r.	PROPN
biomedich-945	139	19	,	,	PUNCT
biomedich-945	139	20	ghimire	ghimire	NOUN
biomedich-945	139	21	,	,	PUNCT
biomedich-945	139	22	s.	s.	PROPN
biomedich-945	139	23	,	,	PUNCT
biomedich-945	139	24	whitmore	whitmore	NOUN
biomedich-945	139	25	,	,	PUNCT
biomedich-945	139	26	a.	a.	PROPN
biomedich-945	139	27	c.	c.	PROPN
biomedich-945	139	28	,	,	PUNCT
biomedich-945	139	29	cassatt	cassatt	PROPN
biomedich-945	139	30	,	,	PUNCT
biomedich-945	139	31	d.	d.	PROPN
biomedich-945	139	32	r.	r.	PROPN
biomedich-945	139	33	,	,	PUNCT
biomedich-945	139	34	&	&	CCONJ
biomedich-945	139	35	burmeister	burmeister	NOUN
biomedich-945	139	36	,	,	PUNCT
biomedich-945	139	37	d.	d.	PROPN
biomedich-945	139	38	m.	m.	PROPN
biomedich-945	139	39	(	(	PUNCT
biomedich-945	139	40	2024	2024	NUM
biomedich-945	139	41	)	)	PUNCT
biomedich-945	139	42	.	.	PUNCT
biomedich-945	140	1	effects	effect	NOUN
biomedich-945	140	2	of	of	ADP
biomedich-945	140	3	combined	combined	ADJ
biomedich-945	140	4	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	140	5	and	and	CCONJ
biomedich-945	140	6	neulasta	neulasta	ADJ
biomedich-945	140	7	therapy	therapy	NOUN
biomedich-945	140	8	on	on	ADP
biomedich-945	140	9	intestinal	intestinal	ADJ
biomedich-945	140	10	pathology	pathology	NOUN
biomedich-945	140	11	and	and	CCONJ
biomedich-945	140	12	gut	gut	NOUN
biomedich-945	140	13	microbiota	microbiota	NOUN
biomedich-945	140	14	after	after	ADP
biomedich-945	140	15	highdose	highdose	ADJ
biomedich-945	140	16	irradiation	irradiation	NOUN
biomedich-945	140	17	in	in	ADP
biomedich-945	140	18	mice	mouse	NOUN
biomedich-945	140	19	.	.	PUNCT
biomedich-945	141	1	frontiers	frontier	NOUN
biomedich-945	141	2	in	in	ADP
biomedich-945	141	3	public	public	ADJ
biomedich-945	141	4	health	health	NOUN
biomedich-945	141	5	,	,	PUNCT
biomedich-945	141	6	12	12	NUM
biomedich-945	141	7	,	,	PUNCT
biomedich-945	141	8	1365161	1365161	NUM
biomedich-945	141	9	.	.	PUNCT
biomedich-945	142	1	https://doi.org/10.3389/fpubh.2024.1365161	https://doi.org/10.3389/fpubh.2024.1365161	PROPN
biomedich-945	142	2	hou	hou	PROPN
biomedich-945	142	3	,	,	PUNCT
biomedich-945	142	4	l.	l.	PROPN
biomedich-945	142	5	(	(	PUNCT
biomedich-945	142	6	2025	2025	NUM
biomedich-945	142	7	)	)	PUNCT
biomedich-945	142	8	.	.	PUNCT
biomedich-945	143	1	short	short	ADJ
biomedich-945	143	2	-	-	PUNCT
biomedich-945	143	3	term	term	NOUN
biomedich-945	143	4	exposure	exposure	NOUN
biomedich-945	143	5	to	to	ADP
biomedich-945	143	6	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	143	7	and	and	CCONJ
biomedich-945	143	8	microplastic	microplastic	ADJ
biomedich-945	143	9	leads	lead	NOUN
biomedich-945	143	10	to	to	ADP
biomedich-945	143	11	weight	weight	NOUN
biomedich-945	143	12	gain	gain	NOUN
biomedich-945	143	13	due	due	ADP
biomedich-945	143	14	to	to	ADP
biomedich-945	143	15	gut	gut	VERB
biomedich-945	143	16	flora	flora	NOUN
biomedich-945	143	17	changes	change	NOUN
biomedich-945	143	18	.	.	PUNCT
biomedich-945	144	1	science	science	NOUN
biomedich-945	144	2	of	of	ADP
biomedich-945	144	3	the	the	DET
biomedich-945	144	4	total	total	ADJ
biomedich-945	144	5	environment	environment	NOUN
biomedich-945	144	6	.	.	PUNCT
biomedich-945	145	1	advance	advance	VERB
biomedich-945	145	2	online	online	ADJ
biomedich-945	145	3	publication	publication	NOUN
biomedich-945	145	4	.	.	PUNCT
biomedich-945	146	1	https://doi.org/10.1016/j.scitotenv.2025.16234	https://doi.org/10.1016/j.scitotenv.2025.16234	PROPN
biomedich-945	146	2	islam	islam	PROPN
biomedich-945	146	3	,	,	PUNCT
biomedich-945	146	4	m.	m.	PROPN
biomedich-945	146	5	s.	s.	PROPN
biomedich-945	146	6	,	,	PUNCT
biomedich-945	146	7	belal	belal	PROPN
biomedich-945	146	8	,	,	PUNCT
biomedich-945	146	9	b.	b.	PROPN
biomedich-945	146	10	,	,	PUNCT
biomedich-945	146	11	dash	dash	NOUN
biomedich-945	146	12	,	,	PUNCT
biomedich-945	146	13	s.	s.	PROPN
biomedich-945	146	14	,	,	PUNCT
biomedich-945	146	15	islam	islam	PROPN
biomedich-945	146	16	,	,	PUNCT
biomedich-945	146	17	m.	m.	PROPN
biomedich-945	146	18	s.	s.	PROPN
biomedich-945	146	19	,	,	PUNCT
biomedich-945	146	20	hasan	hasan	PROPN
biomedich-945	146	21	,	,	PUNCT
biomedich-945	146	22	m.	m.	NOUN
biomedich-945	146	23	m.	m.	NOUN
biomedich-945	146	24	,	,	PUNCT
biomedich-945	146	25	&	&	CCONJ
biomedich-945	146	26	islam	islam	PROPN
biomedich-945	146	27	,	,	PUNCT
biomedich-945	146	28	z.	z.	PROPN
biomedich-945	146	29	(	(	PUNCT
biomedich-945	146	30	2024	2024	NUM
biomedich-945	146	31	)	)	PUNCT
biomedich-945	146	32	.	.	PUNCT
biomedich-945	147	1	chronic	chronic	ADJ
biomedich-945	147	2	exposure	exposure	NOUN
biomedich-945	147	3	of	of	ADP
biomedich-945	147	4	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	147	5	antibiotic	antibiotic	ADJ
biomedich-945	147	6	residue	residue	NOUN
biomedich-945	147	7	above	above	ADP
biomedich-945	147	8	the	the	DET
biomedich-945	147	9	mrl	mrl	PROPN
biomedich-945	147	10	level	level	NOUN
biomedich-945	147	11	and	and	CCONJ
biomedich-945	147	12	its	its	PRON
biomedich-945	147	13	pathophysiological	pathophysiological	ADJ
biomedich-945	147	14	effects	effect	NOUN
biomedich-945	147	15	in	in	ADP
biomedich-945	147	16	mice	mouse	NOUN
biomedich-945	147	17	.	.	PUNCT
biomedich-945	148	1	current	current	ADJ
biomedich-945	148	2	research	research	NOUN
biomedich-945	148	3	in	in	ADP
biomedich-945	148	4	complementary	complementary	ADJ
biomedich-945	148	5	&	&	CCONJ
biomedich-945	148	6	alternative	alternative	ADJ
biomedich-945	148	7	medicine	medicine	NOUN
biomedich-945	148	8	,	,	PUNCT
biomedich-945	148	9	8	8	NUM
biomedich-945	148	10	,	,	PUNCT
biomedich-945	148	11	249	249	NUM
biomedich-945	148	12	.	.	PUNCT
biomedich-945	149	1	https://doi.org/10.29011/2577-2201.100249	https://doi.org/10.29011/2577-2201.100249	PROPN
biomedich-945	149	2	ibrahim	ibrahim	PROPN
biomedich-945	149	3	,	,	PUNCT
biomedich-945	149	4	n.	n.	PROPN
biomedich-945	149	5	a.	a.	PROPN
biomedich-945	149	6	,	,	PUNCT
biomedich-945	149	7	elmorshdy	elmorshdy	NOUN
biomedich-945	149	8	,	,	PUNCT
biomedich-945	149	9	k.	k.	PROPN
biomedich-945	149	10	e.	e.	PROPN
biomedich-945	149	11	,	,	PUNCT
biomedich-945	149	12	radwan	radwan	PROPN
biomedich-945	149	13	,	,	PUNCT
biomedich-945	149	14	d.	d.	PROPN
biomedich-945	149	15	a.	a.	PROPN
biomedich-945	149	16	,	,	PUNCT
biomedich-945	149	17	&	&	CCONJ
biomedich-945	149	18	buabeid	buabeid	PROPN
biomedich-945	149	19	,	,	PUNCT
biomedich-945	149	20	m.	m.	NOUN
biomedich-945	149	21	a.	a.	NOUN
biomedich-945	149	22	(	(	PUNCT
biomedich-945	149	23	2021	2021	NUM
biomedich-945	149	24	)	)	PUNCT
biomedich-945	149	25	.	.	PUNCT
biomedich-945	150	1	the	the	DET
biomedich-945	150	2	impact	impact	NOUN
biomedich-945	150	3	of	of	ADP
biomedich-945	150	4	oral	oral	ADJ
biomedich-945	150	5	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	150	6	on	on	ADP
biomedich-945	150	7	the	the	DET
biomedich-945	150	8	structure	structure	NOUN
biomedich-945	150	9	and	and	CCONJ
biomedich-945	150	10	functions	function	NOUN
biomedich-945	150	11	of	of	ADP
biomedich-945	150	12	rat	rat	NOUN
biomedich-945	150	13	gastric	gastric	ADJ
biomedich-945	150	14	mucosa	mucosa	NOUN
biomedich-945	150	15	:	:	PUNCT
biomedich-945	150	16	histopathological	histopathological	ADJ
biomedich-945	150	17	,	,	PUNCT
biomedich-945	150	18	immunohistochemical	immunohistochemical	ADJ
biomedich-945	150	19	,	,	PUNCT
biomedich-945	150	20	and	and	CCONJ
biomedich-945	150	21	ultrastructural	ultrastructural	ADJ
biomedich-945	150	22	evaluation	evaluation	NOUN
biomedich-945	150	23	.	.	PUNCT
biomedich-945	151	1	saudi	saudi	ADJ
biomedich-945	151	2	journal	journal	NOUN
biomedich-945	151	3	of	of	ADP
biomedich-945	151	4	biological	biological	ADJ
biomedich-945	151	5	sciences	science	NOUN
biomedich-945	151	6	.	.	PUNCT
biomedich-945	152	1	advance	advance	VERB
biomedich-945	152	2	online	online	ADJ
biomedich-945	152	3	publication	publication	NOUN
biomedich-945	152	4	.	.	PUNCT
biomedich-945	153	1	https://doi.org/10.1016/j.sjbs.2021.11.042	https://doi.org/10.1016/j.sjbs.2021.11.042	PROPN
biomedich-945	153	2	liu	liu	PROPN
biomedich-945	153	3	,	,	PUNCT
biomedich-945	153	4	k.	k.	PROPN
biomedich-945	153	5	,	,	PUNCT
biomedich-945	153	6	xia	xia	PROPN
biomedich-945	153	7	,	,	PUNCT
biomedich-945	153	8	y.	y.	PROPN
biomedich-945	153	9	,	,	PUNCT
biomedich-945	153	10	zhang	zhang	PROPN
biomedich-945	153	11	,	,	PUNCT
biomedich-945	153	12	l.	l.	PROPN
biomedich-945	153	13	(	(	PUNCT
biomedich-945	153	14	2024	2024	NUM
biomedich-945	153	15	)	)	PUNCT
biomedich-945	153	16	.	.	PUNCT
biomedich-945	154	1	indomethacin	indomethacin	PROPN
biomedich-945	154	2	combined	combine	VERB
biomedich-945	154	3	with	with	ADP
biomedich-945	154	4	ciprofloxacin	ciprofloxacin	PROPN
biomedich-945	154	5	improves	improve	VERB
biomedich-945	154	6	the	the	DET
biomedich-945	154	7	prognosis	prognosis	NOUN
biomedich-945	154	8	of	of	ADP
biomedich-945	154	9	mice	mouse	NOUN
biomedich-945	154	10	under	under	ADP
biomedich-945	154	11	severe	severe	ADJ
biomedich-945	154	12	traumatic	traumatic	ADJ
biomedich-945	154	13	infection	infection	NOUN
biomedich-945	154	14	via	via	ADP
biomedich-945	154	15	the	the	DET
biomedich-945	154	16	pi3k	pi3k	PROPN
biomedich-945	154	17	/	/	SYM
biomedich-945	154	18	akt	akt	PROPN
biomedich-945	154	19	pathway	pathway	NOUN
biomedich-945	154	20	in	in	ADP
biomedich-945	154	21	macrophages	macrophage	NOUN
biomedich-945	154	22	.	.	PUNCT
biomedich-945	155	1	https://doi.org/10.1016/j.colsurfb.2020.111472?utm_source=chatgpt.com	https://doi.org/10.1016/j.colsurfb.2020.111472?utm_source=chatgpt.com	X
biomedich-945	155	2	https://doi.org/10.1177/117954682211270?utm_source=chatgpt.com	https://doi.org/10.1177/117954682211270?utm_source=chatgpt.com	X
biomedich-945	155	3	https://doi.org/10.1007/s11356-021-14018-7?utm_source=chatgpt.com	https://doi.org/10.1007/s11356-021-14018-7?utm_source=chatgpt.com	X
biomedich-945	156	1	https://doi.org/10.1128/aac.02117-19?utm_source=chatgpt.com	https://doi.org/10.1128/aac.02117-19?utm_source=chatgpt.com	PROPN
biomedich-945	156	2	https://doi.org/10.3389/fpubh.2024.1365161?utm_source=chatgpt.com	https://doi.org/10.3389/fpubh.2024.1365161?utm_source=chatgpt.com	X
biomedich-945	156	3	https://doi.org/10.1016/j.scitotenv.2025.16234?utm_source=chatgpt.com	https://doi.org/10.1016/j.scitotenv.2025.16234?utm_source=chatgpt.com	X
biomedich-945	156	4	https://doi.org/10.29011/2577-2201.100249?utm_source=chatgpt.com	https://doi.org/10.29011/2577-2201.100249?utm_source=chatgpt.com	X
biomedich-945	156	5	https://doi.org/10.1016/j.sjbs.2021.11.042?utm_source=chatgpt.com	https://doi.org/10.1016/j.sjbs.2021.11.042?utm_source=chatgpt.com	X
biomedich-945	156	6	878	878	NUM
biomedich-945	156	7	biology	biology	NOUN
biomedich-945	156	8	,	,	PUNCT
biomedich-945	156	9	medicine	medicine	NOUN
biomedich-945	156	10	,	,	PUNCT
biomedich-945	156	11	&	&	CCONJ
biomedich-945	156	12	natural	natural	ADJ
biomedich-945	156	13	product	product	NOUN
biomedich-945	156	14	chemistry	chemistry	NOUN
biomedich-945	156	15	14	14	NUM
biomedich-945	156	16	(	(	PUNCT
biomedich-945	156	17	2	2	NUM
biomedich-945	156	18	)	)	PUNCT
biomedich-945	156	19	,	,	PUNCT
biomedich-945	156	20	2025	2025	NUM
biomedich-945	156	21	:	:	PUNCT
biomedich-945	156	22	873	873	NUM
biomedich-945	156	23	-	-	SYM
biomedich-945	156	24	878	878	NUM
biomedich-945	156	25	inflammation	inflammation	NOUN
biomedich-945	156	26	,	,	PUNCT
biomedich-945	156	27	47	47	NUM
biomedich-945	156	28	,	,	PUNCT
biomedich-945	156	29	1776–1792	1776–1792	NUM
biomedich-945	156	30	.	.	PUNCT
biomedich-945	156	31	https://doi.org/10.1007/s10753024-02008-3	https://doi.org/10.1007/s10753024-02008-3	PROPN
biomedich-945	156	32	liu	liu	PROPN
biomedich-945	156	33	,	,	PUNCT
biomedich-945	156	34	y.	y.	PROPN
biomedich-945	156	35	,	,	PUNCT
biomedich-945	156	36	chen	chen	PROPN
biomedich-945	156	37	,	,	PUNCT
biomedich-945	156	38	t.	t.	PROPN
biomedich-945	156	39	,	,	PUNCT
biomedich-945	156	40	zhang	zhang	PROPN
biomedich-945	156	41	,	,	PUNCT
biomedich-945	156	42	h.	h.	PROPN
biomedich-945	156	43	,	,	PUNCT
biomedich-945	156	44	&	&	CCONJ
biomedich-945	156	45	saito	saito	PROPN
biomedich-945	156	46	,	,	PUNCT
biomedich-945	156	47	y.	y.	PROPN
biomedich-945	156	48	(	(	PUNCT
biomedich-945	156	49	2025	2025	NUM
biomedich-945	156	50	)	)	PUNCT
biomedich-945	156	51	.	.	PUNCT
biomedich-945	157	1	endoscopic	endoscopic	ADJ
biomedich-945	157	2	diagnosis	diagnosis	NOUN
biomedich-945	157	3	of	of	ADP
biomedich-945	157	4	drug	drug	NOUN
biomedich-945	157	5	-	-	PUNCT
biomedich-945	157	6	induced	induce	VERB
biomedich-945	157	7	gastric	gastric	ADJ
biomedich-945	157	8	mucosal	mucosal	NOUN
biomedich-945	157	9	lesions	lesion	NOUN
biomedich-945	157	10	:	:	PUNCT
biomedich-945	157	11	review	review	NOUN
biomedich-945	157	12	of	of	ADP
biomedich-945	157	13	histopathological	histopathological	ADJ
biomedich-945	157	14	features	feature	NOUN
biomedich-945	157	15	across	across	ADP
biomedich-945	157	16	drug	drug	NOUN
biomedich-945	157	17	types	type	NOUN
biomedich-945	157	18	,	,	PUNCT
biomedich-945	157	19	including	include	VERB
biomedich-945	157	20	antibiotics	antibiotic	NOUN
biomedich-945	157	21	.	.	PUNCT
biomedich-945	158	1	gastroenterological	gastroenterological	ADJ
biomedich-945	158	2	endoscopy	endoscopy	NOUN
biomedich-945	158	3	,	,	PUNCT
biomedich-945	158	4	67(4	67(4	NUM
biomedich-945	158	5	)	)	PUNCT
biomedich-945	158	6	,	,	PUNCT
biomedich-945	158	7	281–288	281–288	NUM
biomedich-945	158	8	.	.	PUNCT
biomedich-945	158	9	https://doi.org/10.11280/gee.67.281	https://doi.org/10.11280/gee.67.281	PROPN
biomedich-945	158	10	mojoyinola	mojoyinola	PROPN
biomedich-945	158	11	,	,	PUNCT
biomedich-945	158	12	a.	a.	NOUN
biomedich-945	158	13	o.	o.	PROPN
biomedich-945	158	14	,	,	PUNCT
biomedich-945	158	15	&	&	CCONJ
biomedich-945	158	16	ogundipe	ogundipe	PROPN
biomedich-945	158	17	,	,	PUNCT
biomedich-945	158	18	o.	o.	PROPN
biomedich-945	158	19	j.	j.	PROPN
biomedich-945	158	20	(	(	PUNCT
biomedich-945	158	21	2023	2023	NUM
biomedich-945	158	22	)	)	PUNCT
biomedich-945	158	23	.	.	PUNCT
biomedich-945	159	1	protective	protective	ADJ
biomedich-945	159	2	effects	effect	NOUN
biomedich-945	159	3	of	of	ADP
biomedich-945	159	4	citrullus	citrullus	ADJ
biomedich-945	159	5	lanatus	lanatus	NOUN
biomedich-945	159	6	seed	seed	NOUN
biomedich-945	159	7	against	against	ADP
biomedich-945	159	8	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	159	9	-	-	PUNCT
biomedich-945	159	10	induced	induce	VERB
biomedich-945	159	11	oxidative	oxidative	ADJ
biomedich-945	159	12	stress	stress	NOUN
biomedich-945	159	13	and	and	CCONJ
biomedich-945	159	14	hepatorenal	hepatorenal	ADJ
biomedich-945	159	15	injury	injury	NOUN
biomedich-945	159	16	in	in	ADP
biomedich-945	159	17	rats	rat	NOUN
biomedich-945	159	18	.	.	PUNCT
biomedich-945	160	1	toxicology	toxicology	NOUN
biomedich-945	160	2	reports	report	NOUN
biomedich-945	160	3	,	,	PUNCT
biomedich-945	160	4	10	10	NUM
biomedich-945	160	5	,	,	PUNCT
biomedich-945	160	6	787–796	787–796	NUM
biomedich-945	160	7	.	.	PUNCT
biomedich-945	161	1	https://doi.org/10.1016/j.toxrep.2023.03.014	https://doi.org/10.1016/j.toxrep.2023.03.014	PROPN
biomedich-945	161	2	nawaz	nawaz	PROPN
biomedich-945	161	3	,	,	PUNCT
biomedich-945	161	4	a.	a.	NOUN
biomedich-945	161	5	(	(	PUNCT
biomedich-945	161	6	2021	2021	NUM
biomedich-945	161	7	)	)	PUNCT
biomedich-945	161	8	.	.	PUNCT
biomedich-945	162	1	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	162	2	-	-	PUNCT
biomedich-945	162	3	loaded	load	VERB
biomedich-945	162	4	gold	gold	NOUN
biomedich-945	162	5	nanoparticles	nanoparticle	NOUN
biomedich-945	162	6	against	against	ADP
biomedich-945	162	7	enterococcus	enterococcus	NOUN
biomedich-945	162	8	faecalis	faecali	NOUN
biomedich-945	162	9	colonization	colonization	NOUN
biomedich-945	162	10	in	in	ADP
biomedich-945	162	11	mice	mouse	NOUN
biomedich-945	162	12	.	.	PUNCT
biomedich-945	163	1	nanomaterials	nanomaterial	NOUN
biomedich-945	163	2	,	,	PUNCT
biomedich-945	163	3	11(11	11(11	NUM
biomedich-945	163	4	)	)	PUNCT
biomedich-945	163	5	,	,	PUNCT
biomedich-945	163	6	3152	3152	NUM
biomedich-945	163	7	.	.	PUNCT
biomedich-945	164	1	https://doi.org/10.3390/nano11113152	https://doi.org/10.3390/nano11113152	PROPN
biomedich-945	164	2	wang	wang	PROPN
biomedich-945	164	3	,	,	PUNCT
biomedich-945	164	4	s.	s.	PROPN
biomedich-945	164	5	,	,	PUNCT
biomedich-945	164	6	patel	patel	PROPN
biomedich-945	164	7	,	,	PUNCT
biomedich-945	164	8	h.	h.	PROPN
biomedich-945	164	9	,	,	PUNCT
biomedich-945	164	10	&	&	CCONJ
biomedich-945	164	11	kim	kim	PROPN
biomedich-945	164	12	,	,	PUNCT
biomedich-945	164	13	j.	j.	PROPN
biomedich-945	164	14	(	(	PUNCT
biomedich-945	164	15	2023	2023	NUM
biomedich-945	164	16	)	)	PUNCT
biomedich-945	164	17	.	.	PUNCT
biomedich-945	165	1	risk	risk	NOUN
biomedich-945	165	2	of	of	ADP
biomedich-945	165	3	gastrointestinal	gastrointestinal	ADJ
biomedich-945	165	4	perforation	perforation	NOUN
biomedich-945	165	5	in	in	ADP
biomedich-945	165	6	patients	patient	NOUN
biomedich-945	165	7	taking	take	VERB
biomedich-945	165	8	oral	oral	ADJ
biomedich-945	165	9	fluoroquinolone	fluoroquinolone	NOUN
biomedich-945	165	10	therapy	therapy	NOUN
biomedich-945	165	11	:	:	PUNCT
biomedich-945	165	12	an	an	DET
biomedich-945	165	13	analysis	analysis	NOUN
biomedich-945	165	14	of	of	ADP
biomedich-945	165	15	a	a	DET
biomedich-945	165	16	nationally	nationally	ADV
biomedich-945	165	17	representative	representative	ADJ
biomedich-945	165	18	cohort	cohort	NOUN
biomedich-945	165	19	.	.	PUNCT
biomedich-945	166	1	journal	journal	NOUN
biomedich-945	166	2	of	of	ADP
biomedich-945	166	3	gastroenterology	gastroenterology	NOUN
biomedich-945	166	4	and	and	CCONJ
biomedich-945	166	5	hepatology	hepatology	NOUN
biomedich-945	166	6	,	,	PUNCT
biomedich-945	166	7	38(7	38(7	NUM
biomedich-945	166	8	)	)	PUNCT
biomedich-945	166	9	,	,	PUNCT
biomedich-945	166	10	1234–1242	1234–1242	NUM
biomedich-945	166	11	.	.	PUNCT
biomedich-945	167	1	https://doi.org/10.1111/jgh.16234	https://doi.org/10.1111/jgh.16234	PROPN
biomedich-945	167	2	xie	xie	PROPN
biomedich-945	167	3	,	,	PUNCT
biomedich-945	167	4	w.-l	w.-l	PROPN
biomedich-945	167	5	.	.	PUNCT
biomedich-945	167	6	,	,	PUNCT
biomedich-945	167	7	ge	ge	PROPN
biomedich-945	167	8	,	,	PUNCT
biomedich-945	167	9	m.-l	m.-l	PROPN
biomedich-945	167	10	.	.	PUNCT
biomedich-945	167	11	,	,	PUNCT
biomedich-945	167	12	chen	chen	PROPN
biomedich-945	167	13	,	,	PUNCT
biomedich-945	167	14	d.	d.	PROPN
biomedich-945	167	15	,	,	PUNCT
biomedich-945	167	16	chen	chen	PROPN
biomedich-945	167	17	,	,	PUNCT
biomedich-945	167	18	g.-q	g.-q	PROPN
biomedich-945	167	19	.	.	PROPN
biomedich-945	167	20	,	,	PUNCT
biomedich-945	167	21	mei	mei	PROPN
biomedich-945	167	22	,	,	PUNCT
biomedich-945	167	23	y.-x	y.-x	PROPN
biomedich-945	167	24	.	.	PROPN
biomedich-945	167	25	,	,	PUNCT
biomedich-945	167	26	&	&	CCONJ
biomedich-945	167	27	lai	lai	PROPN
biomedich-945	167	28	,	,	PUNCT
biomedich-945	167	29	y.-j	y.-j	PROPN
biomedich-945	167	30	.	.	PUNCT
biomedich-945	167	31	(	(	PUNCT
biomedich-945	167	32	2024	2024	NUM
biomedich-945	167	33	)	)	PUNCT
biomedich-945	167	34	.	.	PUNCT
biomedich-945	168	1	psychiatric	psychiatric	ADJ
biomedich-945	168	2	disorders	disorder	NOUN
biomedich-945	168	3	associated	associate	VERB
biomedich-945	168	4	with	with	ADP
biomedich-945	168	5	fluoroquinolones	fluoroquinolone	NOUN
biomedich-945	168	6	:	:	PUNCT
biomedich-945	168	7	a	a	DET
biomedich-945	168	8	pharmacovigilance	pharmacovigilance	NOUN
biomedich-945	168	9	analysis	analysis	NOUN
biomedich-945	168	10	of	of	ADP
biomedich-945	168	11	the	the	DET
biomedich-945	168	12	fda	fda	PROPN
biomedich-945	168	13	adverse	adverse	ADJ
biomedich-945	168	14	event	event	NOUN
biomedich-945	168	15	reporting	report	VERB
biomedich-945	168	16	system	system	NOUN
biomedich-945	168	17	database	database	NOUN
biomedich-945	168	18	.	.	PUNCT
biomedich-945	169	1	frontiers	frontier	NOUN
biomedich-945	169	2	in	in	ADP
biomedich-945	169	3	pharmacology	pharmacology	NOUN
biomedich-945	169	4	,	,	PUNCT
biomedich-945	169	5	15	15	NUM
biomedich-945	169	6	,	,	PUNCT
biomedich-945	169	7	1435923	1435923	NUM
biomedich-945	169	8	.	.	PUNCT
biomedich-945	170	1	https://doi.org/10.3389/fphar.2024.1435923	https://doi.org/10.3389/fphar.2024.1435923	PROPN
biomedich-945	170	2	zhu	zhu	PROPN
biomedich-945	170	3	,	,	PUNCT
biomedich-945	170	4	s.	s.	PROPN
biomedich-945	170	5	(	(	PUNCT
biomedich-945	170	6	2020	2020	NUM
biomedich-945	170	7	)	)	PUNCT
biomedich-945	170	8	.	.	PUNCT
biomedich-945	171	1	high	high	ADJ
biomedich-945	171	2	-	-	PUNCT
biomedich-945	171	3	dose	dose	NOUN
biomedich-945	171	4	ciprofloxacin	ciprofloxacin	NOUN
biomedich-945	171	5	impairs	impair	VERB
biomedich-945	171	6	gut	gut	NOUN
biomedich-945	171	7	barrier	barrier	NOUN
biomedich-945	171	8	integrity	integrity	NOUN
biomedich-945	171	9	:	:	PUNCT
biomedich-945	171	10	evidence	evidence	NOUN
biomedich-945	171	11	of	of	ADP
biomedich-945	171	12	reduced	reduce	VERB
biomedich-945	171	13	tight	tight	ADJ
biomedich-945	171	14	junction	junction	NOUN
biomedich-945	171	15	proteins	protein	NOUN
biomedich-945	171	16	and	and	CCONJ
biomedich-945	171	17	increased	increase	VERB
biomedich-945	171	18	apoptosis	apoptosis	NOUN
biomedich-945	171	19	.	.	PUNCT
biomedich-945	172	1	experimental	experimental	ADJ
biomedich-945	172	2	and	and	CCONJ
biomedich-945	172	3	toxicologic	toxicologic	ADJ
biomedich-945	172	4	pathology	pathology	NOUN
biomedich-945	172	5	,	,	PUNCT
biomedich-945	172	6	72(6	72(6	NOUN
biomedich-945	172	7	)	)	PUNCT
biomedich-945	172	8	,	,	PUNCT
biomedich-945	172	9	403–411	403–411	NUM
biomedich-945	172	10	.	.	PUNCT
biomedich-945	173	1	https://doi.org/10.1016/j.etp.2019.10.006	https://doi.org/10.1016/j.etp.2019.10.006	X
biomedich-945	173	2	https://doi.org/10.1007/s10753-024-02008-3?utm_source=chatgpt.com	https://doi.org/10.1007/s10753-024-02008-3?utm_source=chatgpt.com	PUNCT
biomedich-945	173	3	https://doi.org/10.1007/s10753-024-02008-3?utm_source=chatgpt.com	https://doi.org/10.1007/s10753-024-02008-3?utm_source=chatgpt.com	X
biomedich-945	174	1	https://doi.org/10.11280/gee.67.281?utm_source=chatgpt.com	https://doi.org/10.11280/gee.67.281?utm_source=chatgpt.com	X
biomedich-945	175	1	https://doi.org/10.1016/j.toxrep.2023.03.014?utm_source=chatgpt.com	https://doi.org/10.1016/j.toxrep.2023.03.014?utm_source=chatgpt.com	PROPN
biomedich-945	175	2	https://doi.org/10.3390/nano11113152?utm_source=chatgpt.com	https://doi.org/10.3390/nano11113152?utm_source=chatgpt.com	X
biomedich-945	175	3	https://doi.org/10.1111/jgh.16234?utm_source=chatgpt.com	https://doi.org/10.1111/jgh.16234?utm_source=chatgpt.com	X
biomedich-945	175	4	https://doi.org/10.3389/fphar.2024.1435923?utm_source=chatgpt.com	https://doi.org/10.3389/fphar.2024.1435923?utm_source=chatgpt.com	X
biomedich-945	175	5	https://doi.org/10.1016/j.etp.2019.10.006?utm_source=chatgpt.com	https://doi.org/10.1016/j.etp.2019.10.006?utm_source=chatgpt.com	X