Bibliography

This is an automatically generated bibliography describing the content of this study carrel.

1. cord-001313-f72hl6du
   • author: Toncheva, D.
   • title: NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy
   • date: 2014-05-15
   • words: 3657
   • flesch: 35
   • summary: There is no statistically significant difference between annotated variants in BEN patients and European populations. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.
   • keywords: agents; analysis; angiogenesis; balkan; ben; ben patients; bulgarian; cela1; cells; changes; channels; chronic; controls; development; disease; dna; effect; elastin; endemic; enrichment; evidence; exome; extracellular; factors; familial; fibrosis; frequency; function; genes; genetic; genome; glomerular; groups; healthy; hspg2; illumina; important; injury; interstitial; kcnk5; kidney; kit; matrix; membrane; molecular; muscle; mutations; nephropathy; ngs; nominated; pathogenesis; patients; perlecan; possible; potassium; predisposition; process; progression; protein; regions; remodeling; renal; risk; role; samples; sequencing; serbian; studies; study; variants; vascular
   • versions: original; plain text
2. cord-001525-b7kbyp3s
   • author: Zadrazilova, Iveta
   • title: In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA
   • date: 2015-01-15
   • words: 4355
   • flesch: 37
   • summary: Bactericidal activity is defined as a ratio of MBC to MIC of ≤4 Since antibacterial agents targeting cell wall biosynthesis act as bactericidal agents [30, 34] , the failure in the cell wall biosynthesis due to the inhibition of transglycosylases could be responsible for bactericidal activity of diamides against MRSA.
   • keywords: activity; agents; antibacterial; antimicrobial; assay; aureus; bacterial; bactericidal; bacteriostatic; cfu; clinical; compounds; concentration; control; count; diamides; effect; growth; hydroxy; incubation; infections; inhibitors; inoculum; isolates; kill; killing; log; mbc; methicillin; mic; mrsa; novel; plates; present; reduction; reference; resistant; sals; staphylococcus; starting; strains; study; susceptible; table; tested; time; treatment; values; vancomycin; vitro
   • versions: original; plain text
3. cord-001566-kkaxha7d
   • author: Zhang, Mao-Yu
   • title: Development of Monoclonal Antibodies in China: Overview and Prospects
   • date: 2015-02-25
   • words: 3525
   • flesch: 39
   • summary: The following examples are used to provide a holistic view of mAbs research development in China. Monoclonal antibody therapeutics: history and future Advances in the production and downstream processing of antibodies Continuous cultures of fused cells secreting antibody of predefined specificity Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies Immunogenicity of engineered antibodies Monoclonal antibodies as innovative therapeutics Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains Reshaping human antibodies: grafting an antilysozyme activity Assembly of combinatorial antibody libraries on phage surfaces: the gene III site A surface expression vector for antibody screening By-passing immunisation: human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro Production of fully human antibodies by transgenic mice Highavidity human IgG monoclonal antibodies from a novel strain of minilocus transgenic mice Development trends for human monoclonal antibody therapeutics Monoclonal antibody-from murine to humanized The research progress and trend of biotech drugs in reseach years in China Challenges and prospects for monoclonal antibodies in China Early development of antibody therapeutics: key aspects of advancing an antibody drug from research to clinic The development and trend of antibody drugs Rituximab, an anti-CD20 monoclonal antibody: history and mechanism of action Monoclonal antibody therapy of cancer Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance Monoclonal antibodies against human tumor necrosis factor (TNF), and use there of The efficacy and safety of a third anti-TNF monoclonal antibody in Crohn's disease after failure of two other anti-TNF antibodies Failure of treatment with anti-VEGF monoclonal antibody for longstanding POEMS syndrome Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer Antibodies to watch in 2014: mid-year update Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab Tumor antigentargeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape Monoclonal antibodies-focus point of anti-tumor drugs research Therapeutic effect of infliximab on moderate and severe active rheumatoid arthriti Construction of a single-chain Fv antibody against epidermal growth factor receptor and its antitumor activity Which are the antibodies to watch in 2013 Opportunities and challenges brought by monoclonal antibodies rapid development to biopharmaceutical in China Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Monoclonal antibody purification with hydroxyapatite Human antibodies for immunotherapy development generated via a human B cell hybridoma technology Current and future issues in the manufacturing and development of monoclonal antibodies New technologies for the generation of human monoclonal antibody Biopharmaceutical industrialization prospect in China based on the antibodies Challenges and opportunities of monoclonal antibody manufacturing in China Development of antibody drugs in China Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy Biosimilars: challenges and promises cabs workshop on biosimilar therapeutics The integrated simulation and assessment of the impacts of process change in biotherapeutic antibody production Approval of the first biosimilar antibodies in Europe: a major landmark for the biopharmaceutical industry Advances in antibody manufacturing using mammalian cells
   • keywords: academic; activity; agents; analysis; antibodies; antibody; antitumor; articles; cancer; cfda; challenges; chimeric; china; chinese; clinical; countries; data; development; diseases; drug; enterprises; expression; future; government; high; human; immunological; important; ltd; mabs; market; medical; monoclonal; murine; paper; patent; pharmaceutical; production; products; progress; projects; publications; r&d; registry; research; rituximab; science; shanghai; table; target; technology; therapeutic; therapy; tnf; total; treatment; trials; tumor; university
   • versions: original; plain text
4. cord-001572-ap4ro5me
   • author: Oosterhoff, Dinja
   • title: Hematopoietic Cancer Cell Lines Can Support Replication of Sabin Poliovirus Type 1
   • date: 2015-02-28
   • words: 6158
   • flesch: 46
   • summary: Infection of cell lines at an MOI of 0.01 resulted in high viral titers in the supernatant at day 4. Infection of K562 with passaged Sabin type 1 in a bioreactor system yielded high viral titers in the supernatant. Cell lines that have historically often been used for the production of viral vaccines are MRC-5 and WI-38 [1, 2] .
   • keywords: antigen; capable; capacity; cd155; cell; cell lines; cellular; concentration; culture; data; day; days; determined; development; different; diploid; efficient; expression; figure; hematopoietic; high; hl60; human; inactivated; infection; influenza; k562; k562 cells; kg1; lines; medium; moi; new; number; passaged; per.c6; poliovirus; poliovirus type; production; replication; sabin; sabin poliovirus; samples; serum; study; substrates; supernatant; susceptibility; susceptible; suspension; tested; thp-1; titer; tumor; type; u937; vaccines; vero; vero cells; viral; virus; viruses
   • versions: original; plain text
5. cord-004269-g6ki6vyy
   • author: de Rooij, Doret
   • title: Qualitative Research: Institutional Preparedness During Threats of Infectious Disease Outbreaks
   • date: 2020-01-23
   • words: 5498
   • flesch: 41
   • summary: Per preparedness phase, the participant was asked if and why preparedness activities would be necessary for their healthcare institution. (iii) For ambulance services, preparedness activities start in preparedness phase orange and no clear difference in preparedness activities were identified between preparedness phase orange and preparedness phase red.
   • keywords: academic; activities; additional; ambulance; centralized; collaborative; communication; control; curative; data; different; disease; dutch; ebola; evd; file; focus; general; group; guide; healthcare; hospitals; individual; infectious; institutions; interviews; level; medical; municipal; national; need; orange; outbreak; participants; patients; phase; practitioners; preparedness; preparedness activities; preparedness phase; preparedness system; public; regional; research; response; services; staff; step; study; system; threat; triggers; type; virus; world
   • versions: original; plain text
6. cord-026595-imn2jxcu
   • author: Qamar, Mariam Khan
   • title: What Do the Dental Students Know about Infection Control? A Cross-Sectional Study in a Teaching Hospital, Rawalpindi, Pakistan
   • date: 2020-06-01
   • words: 2417
   • flesch: 47
   • summary: Compliance with infection control programs in private dental clinics in Jordan Attitudes and practices of infection control among senior dental students at college of dentistry, University of Sharjah in the United Arab Emirates Infection control: knowledge and compliance among Saudi undergraduate dental students Updated CDC recommendations for the management of hepatitis B virus-infected health-care providers and students Guidelines for infection control in dental health-care settings-2003 Knowledge, attitudes, and practice regarding infection control measures among dental students in Central India Cross-infection control in Malaysian dental practice Rate of compliance with hand hygiene by dental healthcare personnel (DHCP) within a dentistry healthcare first aid facility Knowledge, attitudes, and practice of infection control among dental students at Sana'a University Knowledge, attitude and practices about hepatitis B and infection control measures among dental students in Patiala Infection control measures in private dental clinics in Lebanon Knowledge, attitude, and practice of needle stick and sharps injuries among dental professionals of Bangalore, India Awareness of droplet and airborne isolation precautions among dental health professionals during the outbreak of corona virus infection in Riyadh city, Saudi Arabia Knowledge, attitude and practice of infection control measures among dental practitioners in public setup of Karachi, Pakistan: cross-sectional survey Compliance with infection control practices in a university hospital dental clinic Knowledge, attitude and compliance of infection control guidelines among dental faculty members and students in KSU Evaluation of Final-Year Turkish Dental Students' Knowledge, Attitude, and Self-Perceived Competency towards Preventive Dentistry Appreciation is hereby extended to the students of Foundation Medical and Dental University for participating in our study. Nevertheless, there is paucity of data with regard to infection control practices among dental students within the hospital environment in Pakistan.
   • keywords: attitude; college; compliance; control; cross; dental; dental students; environment; guidelines; hands; health; hepatitis; hospital; infection; infection control; knowledge; majority; measures; pakistan; patient; practice; prevention; questionnaire; similar; sterilization; students; studies; study; training; university; use; year
   • versions: original; plain text
7. cord-031416-ytbs95wi
   • author: Sabzpoushan, S. H.
   • title: A System Biology-Based Approach for Designing Combination Therapy in Cancer Precision Medicine
   • date: 2020-08-26
   • words: 9622
   • flesch: 45
   • summary: The recognition that cancer cells need their microenvironment to efficiently display their phenotype has opened the door to hypothesize and implement new therapeutic strategies. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2.
   • keywords: absm; age; agents; approach; best; better; biological; biology; biomed; breast; cancer; cancer cells; cancer therapy; case; cells; combination; combined; considered; daughter; day; different; dimensions; division; doses; dpd; drug; ecm; effectiveness; experiments; feature; fibroblasts; figure; fraction; function; groups; growth; help; high; immune; individual; interactions; lattice; like; low; mathematical; means; measure; mechanisms; medicine; microenvironment; modeling; models; na_0; na_1; na_1_1; ncell; necrotic; neighborhood; neuroendocrine; new; nmm; number; oncology; parameters; patient; percent; physical; players; possible; precision; probability; progression; progrowth; proliferation; quantitative; related; research; results; role; rules; set; sets; signal; silico; size; stochastic; strategies; study; system; table; target; therapies; therapy; time; tissue; tme; treatment; tumor; tumor cells; tumor growth; use; value
   • versions: original; plain text
8. cord-259823-ia1g5dt4
   • author: Gowin, Ewelina
   • title: Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience
   • date: 2017-01-15
   • words: 3884
   • flesch: 40
   • summary: Estimates of world-wide distribution of child deaths from acute respiratory infections Acute respiratory infections in children Procalcitonin, Creactive protein and leukocyte count in children with lower respiratory tract infection British Thoracic Society guidelines for the management of community acquired pneumonia in children: update The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America Rekomendacje postępowania w pozaszpitalnych zakażeniach układu oddechowego Viral pneumonia Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Multiplex PCR and emerging technologies for the detection of respiratory pathogens Performance of a novel microarray multiplex PCR for the detection of 23 respiratory pathogens (SYMP-ARI study) Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial Epidemiological investigation of nine respiratory pathogens in hospitalized children in Germany using multiplex reversetranscriptase polymerase chain reaction The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections Epidemiology and virology of acute respiratory infections during the first year of life: a birth cohort study in Vietnam Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Viral infections in immunocompromised patients Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Antibiotic therapy for pediatric community-acquired pneumonia: do we know when, what and for how long to treat? New options in the treatment of respiratory syncytial virus disease Successful treatment of parainfluenza virus respiratory tract infection with DAS181 in 4 immunocompromised children Chemotherapy of respiratory syncytial virus infections: the final breakthrough All authors declare that they have no conflict of interests. FTD respiratory pathogens 33 is an in vitro test with eight multiplex real-time PCR reactions for the qualitative detection of the following viruses, bacteria, and fungi causing respiratory infections: influenza A, B, and C; parainfluenza viruses 1
   • keywords: acute; age; analysis; antibiotic; bacterial; cases; children; clinical; comorbidities; cultures; detection; diagnostic; diseases; etiology; factor; flora; group; hospitalized; infections; influenza; material; microbiological; multiplex; multiplex real; pathogens; patients; pcr; pcr tests; pneumonia; positive; presence; real; respiratory; results; rsv; samples; severe; study; symptoms; tests; therapy; time; time pcr; tract; treatment; viral; viruses
   • versions: original; plain text
9. cord-261633-r4qlbnc5
   • author: Xie, Guo-Hao
   • title: Defensins and Sepsis
   • date: 2014-08-19
   • words: 2928
   • flesch: 35
   • summary: Sepsis, severe sepsis, and septic shock represent a continuum of clinical syndromes which are common complications observed in patients with infection, trauma, and major surgeries [1] [2] [3] . Epidemiology studies demonstrated that severe sepsis has a population prevalence of 300/100 000 in the United States and counts for 10-30% of the intensive care unit (ICU) patients [4] [5] [6] .
   • keywords: -defensin-2; activities; acute; aeruginosa; analysis; antimicrobial; association; bacteria; beta; bonds; cells; copy; defa3; defense; defensins; disease; disulphide; effect; endogenous; epidemiology; expression; gene; genetic; gram; high; host; human; immune; important; infection; inflammatory; injury; innate; level; lung; mechanisms; mouse; mrna; number; outcome; pathogens; patients; peptides; polymorphism; pulmonary; rate; response; roles; sepsis; severe; studies; study; susceptibility; vivo
   • versions: original; plain text
10. cord-262468-7ddgegb2
    • author: Deng, Jianqing
    • title: The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population
    • date: 2020-07-28
    • words: 3654
    • flesch: 38
    • summary: Hyperhomocysteinemia (HHcy), defined as an elevated serum total homocysteine (tHcy) level, is associated with atherosclerotic diseases and intracranial aneurysms as well as abdominal aortic aneurysms (AAAs) Thoracoabdominal aortic aneurysm Thorakoabdominelles Aortenaneurysma Outcomes of 3309 thoracoabdominal aortic aneurysm repairs Editor's choice -hospital incidence, treatment, and in hospital mortality following open and endovascular surgery for thoraco-abdominal aortic aneurysms in Germany from 2005 to 2014: secondary data analysis of the nationwide German DRG microdata Epidemiology and natural history of thoraco-abdominal aortic aneurysms Imaging of thoracoabdominal aortic aneurysms Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population Hyperhomocysteinemia is an independent risk factor for intracranial aneurysms: a case-control study in a Chinese Han population Homocysteine level and risk of abdominal aortic aneurysm: a meta-analysis Abdominal aortic aneurysm and its correlation to plasma homocysteine, and vitamins Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation A new equation to estimate glomerular filtration rate Homocysteine and MTHFR mutations The controversial role of homocysteine in neurology: from labs to clinical practice High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinemiaaggravated abdominal aortic aneurysm Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm Homocysteine induces synthesis of a serine elastase in arterial smooth muscle cells from multi-organ donors Homocysteine modulates the proteolytic potential of human vascular endothelial cells Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury Evaluation of mild hyperhomocysteinemia during the development of atherosclerosis in apolipoprotein E-deficient and normal mice Homocysteine lowering with folic acid and B vitamins in vascular disease
    • keywords: abdominal; acid; adjusted; age; analyses; aneurysms; aortic; association; bmi; case; cells; chinese; cholesterol; concentration; continuous; control; disease; egfr; group; habit; hhcy; higher; history; homocysteine; hyperhomocysteinemia; hypertension; interaction; level; logistic; multivariate; participants; patients; regression; results; risk; serum; serum thcy; sex; smoking; stratified; studies; study; subjects; taaas; thcy; thcy level; thoracoabdominal; variable; vascular; vitamin
    • versions: original; plain text
11. cord-265260-n6wm54wz
    • author: Cuong, Hoang Quoc
    • title: Comparison of Primer-Probe Sets among Different Master Mixes for Laboratory Screening of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
    • date: 2020-09-25
    • words: 2076
    • flesch: 49
    • summary: World Health Organization Feasibility of Controlling COVID-19 Outbreaks by Isolation of Cases and Contacts Risk-adapted treatment strategy for COVID-19 patients Evaluation of WHO listed COVID-19 qPCR primers and probe in silico with 375 SERS-CoV-2 full genome sequences, medRxiv Comparative performance of SARS-CoV-2 detection assays using seven different primer/probe sets and one assay kit Identification of a novel coronavirus in patients with severe acute respiratory syndrome A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam Development of standardized specimens with known concentrations for severe acute respiratory syndrome coronavirus 2 Realtime-RT-PCR testing validation Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data Comparative Analysis of Primer-Probe Sets for the Laboratory Confirmation of SARS-CoV-2 Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer/Probe Sets and One Assay Kit, medRxiv Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets The effect of primer-template mismatches on the detection and quantification of nucleic acids using the 5′ nuclease assay We would like to thank colleagues at Pasteur Institute, Ho Chi Minh City for supporting the study. On the other hand, RT-qPCR assays targeting SARS-CoV-2 depended on the high similarity of SARS-CoV-2 to SARS-CoV as cross-react occurred.
    • keywords: acute; assay; coronavirus; cov-2; covid-19; detection; different; idt; laboratory; lightcycler; master; molbiol; multiplex; phu; primer; probe; qpcr; reaction; results; rna; sars; screening; sets; step; study; syndrome; table; testing; tib; virus
    • versions: original; plain text
12. cord-271106-srym2kh4
    • author: De Rosa, Nicoletta
    • title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study
    • date: 2019-04-11
    • words: 3185
    • flesch: 41
    • summary: HPV infection promotes a cellular immune response, especially in the active phase of the clearance of genital condylomatosis infection, when a cell infiltration of macrophages and T cells develops in correspondence to the lesion [30] . HPV infection is a highly infectious disease; about 65% of partners of individuals with genital warts will develop genital condylomatosis.
    • keywords: age; antiviral; areas; biopsy; case; cell; cervical; colposcopy; condylomatosis; data; degree; echinacea; effect; extension; extracts; follow; gender; genital; genital condylomatosis; group; hpv; human; immune; incidence; individuals; infection; inflammatory; laser; lesions; number; papillomavirus; patients; peniscopy; purpurea; relapse; relapse incidence; response; risk; significant; study; therapy; treatment; trial; viral; warts; women; years
    • versions: original; plain text
13. cord-274056-9t3kneoo
    • author: Abd Elwahaab, Marwa A.
    • title: A Statistical Similarity/Dissimilarity Analysis of Protein Sequences Based on a Novel Group Representative Vector
    • date: 2019-05-08
    • words: 3315
    • flesch: 55
    • summary: 2D and 3D amino acid adjacency matrices A new method to analyze protein sequence similarity using dynamic time warping A 2D graphical representation of protein sequence and its numerical characterization Graphical representation and similarity analysis of protein sequences based on fractal interpolation ADLD: a novel graphical representation of protein sequences and its application Comparative analysis of protein primary sequences with graph energy UC-curve: a highly compact 2D graphical representation of protein sequences The graphical representation of protein sequences based on the physicochemical properties and its applications F-curve, a graphical representation of protein sequences for similarity analysis based on physicochemical properties of amino acids A novel method of 2D graphical representation for proteins and its application 3D graphical representation of protein sequences and their statistical characterization Novel numerical characterization of protein sequences based on individual amino acid and its application Similarities/dissimilarities analysis of protein sequences based on PCA-FFT On novel representation of proteins based on amino acid adjacency matrix A sequence-segmented method applied to the similarity analysis of long protein sequence It is a figure which summarizes our approach. In our work, a representative of each of three groups of protein sequences is introduced.
    • keywords: acid; adjacency; alignment; amino; analysis; approach; beta; comparison; degree; dissimilarity; elements; figure; globin; graphical; group; human; matrix; methods; nd5; number; phylogenetic; protein; related; representative; results; sample; selected; sequences; set; similarity; species; spike; table; vector
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14. cord-279528-41atidai
    • author: Abo-Elkhier, Mervat M.
    • title: Measuring Similarity among Protein Sequences Using a New Descriptor
    • date: 2019-11-22
    • words: 3048
    • flesch: 52
    • summary: The graphical representation of protein sequence is a simple way to visualize protein sequences. Basic local alignment search tool Gapped BLAST and PSI-BLAST: a new generation of protein database search programs CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Graphical representation of proteins Similarity/dissimilarity calculation methods of DNA sequences: a survey Highly compact 2D graphical representation of DNA sequences, SAR and QSAR Unique graphical representation of protein sequences based on nucleotide triplet codons Novel 2-D graphical representation of proteins Representation of protein sequences on latitude-like circles and longitude-like semi-circles On a geometry-based approach to protein sequence alignment DNA sequence comparison by a novel probabilistic method 2-D Graphical representation of proteins based on physico-chemical properties of amino acids A 2D graphical representation of protein sequence and its numerical characterization 3-D maps and coupling numbers for protein sequences 3D graphical representation of protein sequences and their statistical characterization DNA sequence representation without degeneracy Protein map: an alignment-free sequence comparison method based on various properties of amino acids On novel representation of proteins based on amino acid adjacency matrix Protein alignment: exact versus approximate.
    • keywords: acid; alignment; amino; analysis; approach; beta; chimpanzee; class; clustalw; correlation; data; descriptor; deviation; dissimilarity; dna; globin; graphical; human; intensity; level; matrix; methods; nd5; new; novel; protein; representation; results; sequences; significance; similarity; standard; table; value; vector
    • versions: original; plain text
15. cord-280908-o1z4ka3r
    • author: Vieira, Sandra E.
    • title: Infections Caused by HRSV A ON1 Are Predominant among Hospitalized Infants with Bronchiolitis in São Paulo City
    • date: 2017-05-24
    • words: 3070
    • flesch: 42
    • summary: After genotype HRSV A ON1, BA9 was the second most frequent genotype identified in the present study. These results need to be confirmed by more extensive analyses but are consistent with a previous German study that found no clinical differences between infections by other HRSV genotypes [17] .
    • keywords: age; analyses; authors; bronchiolitis; cases; characteristics; children; city; clinical; cluster; gene; genotypes; hospital; hrsv; human; infants; infections; isolates; na1; na2; new; on1; paulo; pcr; population; predominance; previous; protein; region; respiratory; samples; sequenced; severity; similar; studies; study; syncytial; são; usa; virus; years
    • versions: original; plain text
16. cord-283092-t3yqsac3
    • author: Shah, Kamal
    • title: Qualitative Analysis of a Mathematical Model in the Time of COVID-19
    • date: 2020-05-25
    • words: 3348
    • flesch: 51
    • summary: From Figure 3 , when we involve immigration of infected class and cease the immigration for the healthy class, we see that the population density of infected class is going up with different rates due to fractional order derivative during in first 250 days. In this article, we have examined a population model of the novel COVID-19 under ABC fractional order derivatives.
    • keywords: abc; analysis; authors; china; class; considered; covid-19; derivative; different; differential; disease; existence; fractional; healthy; immigration; infected; infection; mathematical; model; new; novel; operators; order; people; point; population; problems; rate; results; section; series; solution; study; terms; theorem; theory; type; uniqueness
    • versions: original; plain text
17. cord-293503-e7be12qb
    • author: Xiang, Chao
    • title: CT Findings in a Novel Coronavirus Disease (COVID-19) Pneumonia at Initial Presentation
    • date: 2020-08-15
    • words: 3322
    • flesch: 46
    • summary: Most types of COVID-19 pneumonia have abnormal radiographic changes at initial presentation, and CT features and patterns are similar to those of viral pneumonia. Although a patient with exposure history may be asymptomatic and obtained negative results of CT findings and viral nucleic acid test at initial presentation, the potential infection cannot be totally excluded, and performing repeating CT scan and coronavirus RNA test is needed.
    • keywords: acid; acute; basal; cases; changes; china; clinical; consolidation; coronavirus; cov-2; covid-19; data; disease; distribution; exposure; features; findings; glass; ground; history; infected; infection; initial; interstitial; lesions; lobe; lower; lung; mers; novel; nucleic; opacity; patients; pattern; pneumonia; pulmonary; respiratory; right; sars; scan; segment; severe; similar; study; syndrome; viral; wuhan
    • versions: original; plain text
18. cord-296033-5zyoddl7
    • author: Hu, Xiaoliang
    • title: Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-β through Its Deubiquitinase Activity
    • date: 2017-10-23
    • words: 3385
    • flesch: 43
    • summary: However, very little is known about whether TGEV PL1 can antagonize host innate immune response. Here, we presented evidence that TGEV PL1 encoded by the replicase gene could suppress the IFN-β expression and inhibit the nuclear translocation of interferon regulatory factor 3 (IRF3).
    • keywords: activation; activity; antiviral; catalytic; cells; coronavirus; cov; dependent; deubiquitinase; dub; expression; factor; figure; flag; gene; hek293; host; ifn; immune; immunity; innate; interferon; irf3; like; luciferase; nl63; nuclear; papain; pl1; plasmids; porcine; presence; production; promoter; protease; protein; respiratory; response; rig-1; sars; sev; signaling; sting; syndrome; tgev; tgev pl1; type; viral; virus
    • versions: original; plain text
19. cord-296682-ugffeegr
    • author: Rahimi, Hoda
    • title: A Comprehensive Review of Cutaneous Manifestations Associated with COVID-19
    • date: 2020-07-05
    • words: 1776
    • flesch: 47
    • summary: The second most frequent skin rash in COVID-19 patients was urticaria which appeared in 84 patients (18.6%). Cutaneous Lymphoid Hyperplasia Associated with Leishmania panamensis Infection Comment on Cutaneous manifestations in COVID-19: a first perspective by Recalcati S Morbilliform exanthem associated with COVID-19 A case of COVID-19 pneumonia in a young male with full body rash as a presenting symptom Manifestaciones cutaneas en contexto del brote actual de enfermedad por coronavirus 2019 Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases Comment on: Cutaneous manifestations in COVID-19: a first perspective.
    • keywords: age; asymptomatic; cases; chilblain; coronavirus; cov-2; covid-19; cutaneous; different; disease; infection; lesions; livedo; manifestations; patients; phase; presentations; pts; rash; reported; reticularis; sars; skin; years
    • versions: original; plain text
20. cord-298185-w37nvorf
    • author: Cao, Kai
    • title: Current Evidence of 2019 Novel Coronavirus Disease (COVID-19) Ocular Transmission: A Systematic Review and Meta-Analysis
    • date: 2020-10-24
    • words: 2558
    • flesch: 47
    • summary: The evidence on the positive rate of conjunctival swab samples and the prevalence rates of ocular symptoms indicated that COVID-19 ocular transmission was possible but less likely. Similarly, our meta-analysis found that up to 10% of COVID-19 patients had ocular symptoms and 3% of conjunctival swab samples were positive in COVID-19 patients, supporting the possibility of transmission through the ocular surface.
    • keywords: ace2; analysis; body; congestion; conjunctival; conjunctivitis; coronavirus; cov-2; covid-19; disease; eye; foreign; heterogeneity; human; meta; ocular; patients; pooled; positive; prevalence; rate; samples; sars; sensation; studies; study; swab; symptoms; transmission; ying
    • versions: original; plain text
21. cord-299552-rgrm8dil
    • author: Bianchi, Martina
    • title: Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
    • date: 2020-05-30
    • words: 2089
    • flesch: 46
    • summary: Development of effective therapeutic and prevention strategies is significantly hampered also by the lack of detailed structural information on virus proteins, although several crystallographic structures of Sars-CoV-2 proteins are now available Indeed, a number of examples have been reported in the scientific literature suggesting how even single point mutations in virus proteins can significantly alter their biology and pathogenesis
    • keywords: accession; alignment; bat; code; coronavirus; cov-2; covid-19; cross; data; envelope; figure; genbank; homologous; homology; human; isolates; membrane; model; multiple; mutations; pangolin; position; prediction; properties; protein; sars; sequence; species; specific; spike; structural; transmembrane; variants; virus
    • versions: original; plain text
22. cord-300944-c57impca
    • author: Huang, Xiaolan
    • title: A Genome-Wide Analysis of RNA Pseudoknots That Stimulate Efficient −1 Ribosomal Frameshifting or Readthrough in Animal Viruses
    • date: 2013-11-04
    • words: 8631
    • flesch: 54
    • summary: Venezuelan equine encephalitis virus (VEEV, NC 001449); Western equine encephalitis virus Whataroa virus (WHAV, AF339479) Recoding: reprogrammed genetic decoding Recoding: translational bifurcations in gene expression Ribosome gymnastics-degree of difficulty 9.5, style 10.0 Recoding: dynamic reprogramming of translation Viral RNA pseudoknots: versatile motifs in gene expression and replication Normal tRNAs promote ribosomal frameshifting Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting A new principle of RNA folding based on pseudoknotting Pseudoknots: a new motif in the RNA game Structural and functional aspects of RNA pseudoknots Ribosomal frameshifting on viral RNAs Programmed translational frameshifting Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting Programmed ribosomal frameshifting in decoding the SARS-CoV genome Regulation of programmed ribosomal frameshifting by cotranslational refolding RNA hairpins Programmed -1 ribosomal frameshifting in the SARS coronavirus A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus Frameshifting in alphaviruses: a diversity of 3' stimulatory structures Evidence that a downstream pseudoknot is required for translational read-through of the Moloney murine leukemia virus gag stop codon Bipartite signal for read-through suppression in murine leukemia virus mRNA: an eight-nucleotide purine-rich sequence immediately downstream of the gag termination codon followed by an RNA pseudoknot RNA pseudoknots: translational frameshifting and readthrough on viral RNAs Pseudoknot-dependent read-through of retroviral gag termination codons: importance of sequences in the spacer and loop 2 Base-pairings within the RNA pseudoknot associated with the simian retrovirus-1 gag-pro frameshift site Solution structure of the pseudoknot of SRV-1 RNA, involved in ribosomal frameshifting Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot Specific mutations in a viral RNA pseudoknot drastically change ribosomal frameshifting efficiency Solution structure of a luteoviral P1-P2 frameshifting mRNA pseudoknot Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif A loop 2 cytidinestem 1 minor groove interaction as a positive determinant for pseudoknot-stimulated -1 ribosomal frameshifting Ribosomal pausing at a frameshifter RNA pseudoknot is sensitive to reading phase but shows little correlation with frameshift efficiency Ribosomal pausing during translation of an RNA pseudoknot Ribosomal movement impeded at a pseudoknot required for frameshifting A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting Torsional restraint: a new twist on frameshifting pseudoknots Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of -1 ribosomal frameshifting Characterization of the mechanical unfolding of RNA pseudoknots MRNA pseudoknot structures can act as ribosomal roadblocks Predicting thermodynamic properties of RNA Recode-2: new design, new search tools, and many more genes Analysis of the role of the pseudoknot component in the SRV-1 gag-pro ribosomal frameshift signal: loop lengths and stability of the stem regions Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV Complete genomic sequence and phylogenetic analysis of the lactate dehydrogenase-elevating virus The involvement of RNA pseudoknots in stop codon readthrough has also been established.
    • keywords: 1st; analysis; basepairs; calculated; codon; database; default; detected; different; downstream; efficient; energy; family; figure; form; frameshift; frameshift site; frameshift stimulator; frameshifting; free; free energy; gag; gene; genomic; hiv-1; human; junction; kcal; lengths; leukemia; loop; mechanical; mechanism; mol; mrna; nucleotides; number; pol; pol frameshift; possible; possible pseudoknots; potential; potential pseudoknots; prf; pro; program; pseudoknots; putative; ranges; readthrough; recode; recoding; region; retroviruses; ribosomal; ribosomes; rna; rna pseudoknots; search; sequence; signal; site; slippery; spacer; srv-1; stability; stem; stimulator; stimulator pseudoknots; stop; strength; strong; structure; study; table; type; type pseudoknots; viral; virus; viruses
    • versions: original; plain text
23. cord-303978-z3888e3g
    • author: Hong, Ka Lok
    • title: Single-Stranded DNA Aptamers against Pathogens and Toxins: Identification and Biosensing Applications
    • date: 2015-06-23
    • words: 15737
    • flesch: 39
    • summary: After the retrieval of target bound ssDNA molecules for each round of selection, a small-scale PCR can be carried out to determine the cycles of PCR needed to successfully amplify the library. It then summarizes advancements in the identification and biosensing application of ssDNA aptamers specific for bacteria, viruses, their associated molecules, and selected chemical toxins.
    • keywords: able; acid; activities; addition; affinities; affinity; aflatoxin; alpha; amplification; analysis; anthrax; antibodies; antibody; antigen; application; aptamers; aptasensor; assay; associated; atrazine; aunps; aureus; authors; bacteria; beads; best; binding; biosensing; biosensor; bisphenol; bont; botulinum; bovine; candidate; candidate mre; capillary; capture; capturing; carbon; cause; cell; cfu; change; characterization; coated; coli; colorimetric; conformational; counter; coworkers; cross; detection; detection assay; determination; development; different; difficile; dna aptamers; electrochemical; electrode; electrophoresis; elements; enterotoxin; environmental; enzyme; escherichia; et al; figure; flow; fluorescence; food; free; general; gold; gram; graphene; group; high; high affinity; human; identification; immobilization; immobilized; impedimetric; increase; infections; influenza; label; library; linked; listeria; lod; low; magnetic; method; modified; molecular; molecules; monocytogenes; mre; mre specific; mres; multiple; nanomolar; nanoparticles; negative; negative selection; nucleic; ochratoxin; ota; oxide; pcr; pesticides; positive; primer; process; protein; random; range; rapid; recognition; redox; region; reported; resonance; review; rna; rounds; salmonella; samples; sandwich; selected; selection; selective; selex; sensitive; sensitivity; separation; sequences; serum; signal; similar; single; small; solution; species; specific; specificity; spores; spr; ssdna; ssdna mre; staphylococcus; strains; strand; streptavidin; streptococcus; study; surface; system; target; target selection; time; toxins; tuberculosis; type; typhimurium; ultrasensitive; unbound; use; values; vibrio; virus; water; wine
    • versions: original; plain text
24. cord-306411-dutbxfl4
    • author: Eifan, Saleh A.
    • title: Respiratory Tract Viral Infections and Coinfections Identified by Anyplex™ II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital
    • date: 2017-11-21
    • words: 2643
    • flesch: 34
    • summary: Respiratory Pathogens in Children with and without Respiratory Symptoms Epidemiology of respiratory viral infection using multiplex RT-PCR in Virological and clinical characterizations of respiratory infections in hospitalized children Ten year retrospective evaluation of the seasonal distribution of agent viruses in childhood respiratory tract infections Epidemiological and clinical characteristics of respiratory viral infections in children in Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province, China Other viruses (e.g. pox, papilloma, parvo, reoviridae) Viral coinfection in childhood respiratory tract infections Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon Etiology, seasonality, and clinical characteristics of respiratory viruses in children with respiratory tract infections in Eastern India (Bhubaneswar, Odisha) Respiratory virus infections are a major public health problem, due to the ease of spread and considerable morbidity and mortality.
    • keywords: acute; adv; age; anyplex; arabia; bocavirus; children; clinical; detection; different; distribution; etiology; hbov; hospitalized; hrv; human; infections; information; multiplex; pathogens; patients; pcr; real; respiratory; rhinovirus; rsv; rv16; samples; saudi; seasonal; seegene; single; study; time; tract; viral; viruses; year
    • versions: original; plain text
25. cord-309319-si5c14e8
    • author: Cao, Chunxiang
    • title: Analysis of Spatiotemporal Characteristics of Pandemic SARS Spread in Mainland China
    • date: 2016-08-15
    • words: 4697
    • flesch: 42
    • summary: The BME reveals that SARS outbreaks show autocorrelation within certain spatial and temporal distances. On February 1, 2003, during the period of SARS outbreaks, the Spring Festival took place.
    • keywords: acute; affected; analysis; areas; beijing; bme; cases; characteristics; china; cities; control; correlation; county; covariance; data; date; disease; distance; distribution; domain; dynamics; empirical; epidemic; epidemiological; estimation; field; figure; following; geographic; health; higher; infectious; information; location; mainland; mapping; maximum; method; model; modelling; movement; number; observed; onset; outbreaks; pandemic; people; period; person; population; process; records; research; residence; respiratory; sars; severe; space; spatial; spatiotemporal; spread; statistical; stochastic; study; syndrome; temporal; time; transmission; trf; value
    • versions: original; plain text
26. cord-311625-d7iycdyh
    • author: Choong, Oi Kuan
    • title: In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
    • date: 2014-02-20
    • words: 4024
    • flesch: 48
    • summary: Both ends of the duplex TFOs were ligated with a linker sequence or clamps (C-C) to construct circular TFO RNA. One hundred nM of circular TFO RNA was transfected into MDCK cells.
    • keywords: activity; analysis; antiviral; binding; cats; cells; circular; circular tfo; copy; coronavirus; crfk; data; designed; emsa; fcov; fecv; feline; figure; fipv; formation; gel; genome; helix; hours; infected; infectious; inhibit; linear; oligonucleotides; peritonitis; plate; potential; regions; replication; rna; rnas; significant; strain; study; table; target; tfo; tfo1; tfo2; tfo3; tfo4; tfo5; tfos; therapy; transcription; transfection; treatments; triple; virulent; virus
    • versions: original; plain text
27. cord-316181-ccauw70y
    • author: Yang, Fude
    • title: Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology
    • date: 2017-05-16
    • words: 5736
    • flesch: 29
    • summary: Autophagy: process and function Autophagy modulation as a potential therapeutic target for diverse diseases The role of autophagy in cancer: therapeutic implications The dual role of autophagy in cancer Role of autophagy in aging Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD) Assessment of the effects of Radix Bupleuri and vinegarbaked Radix Bupleuri on cytochrome 450 activity by a six-drug cocktail approach Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of -glucuronidase Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells Saikosaponin C induces endothelial cells growth, migration and capillary tube formation A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent Anthelmintic activity of saikosaponins a and d from radix bupleuri against Dactylogyrus spp. The results showed that both raw and processed Radix Bupleuri showed liver protective effects against CCl 4 induced liver injury, and the vinegar-baked Radix Bupleuri exerted better effects than that of raw Radix Bupleuri
    • keywords: a549; activation; activities; activity; acute; analysis; anti; anticancer; antipyretic; antiviral; autophagy; bioactive; biological; bupleuri; bupleurum; cancer; cells; chai; chaihu; chemical; china; chinese; chromatography; compounds; concentration; constituents; crude; dependent; determination; diseases; dose; drug; effects; endothelial; essential; evaluation; expression; extract; fever; hbv; hepatitis; hepatoprotective; herbal; high; human; immunomodulatory; induced; inflammatory; inhibition; injury; isolated; liquid; liver; lung; major; mechanism; medicine; new; novel; oil; pathway; pharmacological; pharmacology; phytochemistry; polyacetylenes; potential; production; protective; radix; radix bupleuri; rats; raw; results; review; roots; saikosaponins; scorzonerifolium; signaling; species; ssa; ssc; ssd; studies; study; therapeutic; traditional; treatment; triterpenoid; uses; virus; vitro; vivo; water; xiao
    • versions: original; plain text
28. cord-319635-kh99n7q2
    • author: Chiang, Wei-Wei
    • title: Cell Type-Dependent RNA Recombination Frequency in the Japanese Encephalitis Virus
    • date: 2014-07-22
    • words: 5136
    • flesch: 48
    • summary: Notably, viral RNAs usually accumulated at a lower amount in mosquito cells through RNase cleavage as well as RNA-mediated pathways, leading to stagnancy of RNA recombination which may brake evolution of the JEV and probably most, if not all, arboviruses which are maintained in nature by alternate cycles involving mosquitoes and vertebrates [28] . Autoimmunity-related demyelination in infection by Japanese encephalitis virus Flavivirus encephalitis Flaviviridae: the viruses and their replication Complete nucleotide sequence of the Japanese encephalitis virus genome RNA Quasispecies theory in virology Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet Genetic diversity in RNA virus quasispecies is controlled by host-virus interactions Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells E/NS1 modifications of dengue 2 virus after serial passages in mammalian and/or mosquito cells The advantage of sex in the RNA virus 6 Genetic evolution of Japanese encephalitis virus Evolutionary aspects of recombination in RNA viruses A genetic map of poliovirus temperaturesensitive mutants Heterologous recombination in the double-stranded RNA bacteriophage 6 RNA recombination in brome mosaic virus, a model plus strand RNA virus How RNA viruses exchange their genetic material The extent of homologous recombination in members of the genus Flavivirus A phylogenetic survey of recombination frequency in plant RNA viruses Western equine encephalitis virus is a recombinant virus Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome suquences Phylogenetic evidence for recombination in dengue virus RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease Adaptation of two flaviviruses results in differences in genetic heterogeneity and virus adaptability Quasispecies of dengue virus Experimental evidence that RNA recombination occurs in the Japanese encephalitis virus Genetic diversity and slow rates of evolution in new world alphaviruses Mutations in the NS3 gene and 3 -NCR of Japanese encephalitis virus isolated from an unconventional ecosystem and implications for natural attenuation of the virus Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis Mutation rates among RNA viruses Why do RNA viruses recombine? RNA viruses generate new genetic strains with approximately 6 orders of magnitude higher rates of nucleotide substitutions compared to DNA viruses [28] .
    • keywords: -end; -utr; amplified; c6/36; c6/36 cells; cells; cjn; control; different; dna; dsrna; early; encephalitis; evolution; exoribonuclease; figure; fold; form; fragment; frequency; genetic; genome; host; hpi; infected; infection; japanese; jev; level; mammalian; min; mosquito; pap; pcr; plasmid; previous; primer; recombination; result; rna; rna recombination; rnas; sense; sequence; single; strains; t1p1; transfection; usa; viral; virus; viruses
    • versions: original; plain text
29. cord-321953-yql6gpd3
    • author: Barrera, Maritza
    • title: Tracking the Origin and Deciphering the Phylogenetic Relationship of Porcine Epidemic Diarrhea Virus in Ecuador
    • date: 2017-12-12
    • words: 3596
    • flesch: 47
    • summary: In this study, a rigorous measurement of the global phylogeographic approach for PEDV strains was performed based on complete S gene sequences. The present work is the first study providing evidences that PEDV strains are circulating into Ecuador swine herds and revealing the molecular characteristic of the PEDV isolate in the South American region.
    • keywords: analysis; bayesian; canada; china; chinese; complete; coronavirus; cotopaxi/2014; diarrhea; diarrhea virus; different; disease; ecuador; epidemic; epidemic diarrhea; epidemiological; epidemiology; field; figure; genbank; gene; genome; introduction; korea; material; mexico; molecular; movement; new; origin; outbreak; pedv; pedv strains; phylogenetic; phylogeographic; pigs; porcine; porcine epidemic; protein; s gene; sequences; software; south; spread; spreading; states; strains; studies; study; supplementary; swine; table; tree; united; viral; virus
    • versions: original; plain text
30. cord-330276-qvmhuid3
    • author: Giorgi, Gabriele
    • title: Addressing Risks: Mental Health, Work-Related Stress, and Occupational Disease Management to Enhance Well-Being 2019
    • date: 2020-06-19
    • words: 2302
    • flesch: 32
    • summary: In addition, a focus on coping strategies by X. Wang et al. revealed that 2 BioMed Research International depressive symptoms in military institutions is a matter that needs to be considered, as they found that the relationship between coping (i.e., hardiness) and depressive symptoms is mediated by motivational dispositions. Similarly, S. Berlanda et al. analyzed the experiences of violence (emotional, physical, and sexual) perpetrated by patients and visitors against healthcare professionals working in emergency units.
    • keywords: academic; addition; anxiety; approach; burnout; consequences; diseases; economic; factors; findings; group; harassment; health; higher; issue; job; levels; measures; mental; need; occupational; organizational; problems; psychosocial; ratings; relationship; research; results; risks; self; special; stress; students; study; violence; work; workers; working; workplace
    • versions: original; plain text
31. cord-330602-g0xaonxv
    • author: Sugiura, Hiroaki
    • title: Prescription Surveillance and Polymerase Chain Reaction Testing to Identify Pathogens during Outbreaks of Infection
    • date: 2013-02-07
    • words: 3232
    • flesch: 30
    • summary: Therefore, syndromic surveillance systems have been implemented in many countries since 1995 The scheme proposed by the present study uses PCR testing triggered by detection alerts from syndromic surveillance systems.
    • keywords: adenovirus; agents; cases; children; detection; diagnosis; diseases; drugs; early; infections; influenza; information; japan; japanese; kit; medical; number; outbreak; pathogens; patients; pcr; pneumoniae; positive; prescription; present; rapid; respiratory; results; rsv; specificity; study; surveillance; symptoms; syndromic; system; testing; time; tract; traditional; upper; virus; viruses; years
    • versions: original; plain text
32. cord-335620-xqokfg3l
    • author: Wang, Anqi
    • title: Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection
    • date: 2017-03-13
    • words: 4941
    • flesch: 53
    • summary: Moreover, goose IFITM1 was highly constitutively expressed in gastrointestinal tract tissues, while goose IFITM3 was expressed in respiratory organs. Furthermore, goose IFITM3 was activated in goose peripheral blood mononuclear cells (PBMCs) infected with Tembusu virus (TMUV) or treated with Toll-like receptors (TLRs) agonists, while only the R848 and Poly (I:C) agonists induced significant upregulation of goose IFITM1.
    • keywords: acid; addition; agonists; alignment; amino; analysis; antiviral; avian; c c; c g; c t; cdna; cecum; cell; chicken; china; conserved; copy; duck; entry; expression; figure; g g; gallus; geese; genbank; gene; goose; goose ifitm1; group; high; identity; ifitm3; ifitm3 ifitm3; immune; induced; infection; influenza; interferon; levels; like; lung; numbers; pairwise; pcr; primer; proteins; qrt; r848; region; rna; sequences; significant; small; species; t g; t t; tembusu; terminal; thymus; tissues; tmuv; transmembrane; usa; virus; viruses
    • versions: original; plain text
33. cord-336177-p7b7yw28
    • author: Selvi, Valeria
    • title: Convalescent Plasma: A Challenging Tool to Treat COVID-19 Patients—A Lesson from the Past and New Perspectives
    • date: 2020-09-22
    • words: 5464
    • flesch: 40
    • summary: WHO Pandemia WHO Director-General's opening remarks at the media briefing on COVID-19 -11 Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2 Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save livescurrent situation and perspectives Convalescent plasma as a potential therapy for COVID-19 Blood transfusion during the COVID-19 outbreak A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19 Treatment of COVID-19: old tricks for new challenges The convalescent sera option for containing COVID-19 Passive immunity in prevention and treatment of infectious diseases Convalescent plasma: new evidence for an old therapeutic tool? Points to consider in the preparation and transfusion of COVID-19 convalescent plasma Ebola virus convalescent blood products: where we are now and where we may need to go Evaluation of convalescent whole blood for treating Ebola virus disease in Convalescent plasma in Covid-19: possible mechanisms of action An augmented passive immune therapy to treat fulminant bacterial infections Position paper on use of convalescent plasma, serum or immune globulin concentrates as an element in response to an emerging virus Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome Use of convalescent plasma therapy in SARS patients in Hong Kong Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection Hyperimmune IV immunoglobulin Treatment The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients Efficacy of convalescent plasma in relation to dose of Ebola virus antibodies Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Risks and side effects of therapy with plasma and plasma fractions Treatment for emerging viruses: convalescent plasma and COVID-19 Safety update: COVID-19 convalescent plasma in 20,000 hospitalized patients Recommendations for investigational COVID-19 convalescent plasma-Food and Drug Administration Convalescent plasma is a clutch at straws in COVID-19 management! However, convalescent plasma was demonstrated to be associated with antiviral activity in patients with COVID-19 (convalescent plasma treatment was associated with higher rates of negative SARS-CoV-2 viral PCR results from nasopharyngeal swabs at 24, 48, and 72 hours); a statistically significant improvement was noted for the convalescent plasma treatment group compared to controls in the subgroup of patients without life-threatening COVID-19 (91% improvement in the plasma group compared to 68% in the control arm).
    • keywords: addition; administration; adverse; analysis; antibodies; antibody; authors; available; blood; case; clinical; control; convalescent; convalescent plasma; coronavirus; cov-2; covid-19; days; disease; donor; drug; early; ebola; effectiveness; effects; efficacy; events; group; health; high; human; ill; immune; immunization; immunoglobulin; infection; influenza; life; mortality; new; pandemic; passive; patients; plasma; possible; rate; reactions; recipient; recovered; respiratory; results; risk; safety; sars; serum; severe; streptococcus; studies; study; therapy; time; titer; transfusion; treatment; trials; use; viral; virus; world
    • versions: original; plain text
34. cord-344061-gsl84nv6
    • author: Pariani, Elena
    • title: Influenza and Other Respiratory Viruses Involved in Severe Acute Respiratory Disease in Northern Italy during the Pandemic and Postpandemic Period (2009–2011)
    • date: 2014-06-12
    • words: 2090
    • flesch: 34
    • summary: The proportion of SARI/ARDS cases associated with respiratory viruses other than A(H1N1)pdm09 was significantly lower (19.4% versus 58.3%, value <0.0000001). Severe respiratory diseases associated with respiratory viruses other than A(H1N1)pdm09 were detected more frequently among children ≤ 5 years (13.3% versus 30%, value = 0.02).
    • keywords: a(h1n1)pdm09; acute; aged; ards; cases; clinical; diagnosis; disease; fatal; human; infection; influenza; laboratory; mortality; negative; pandemic; pathogens; patients; pcr; period; pneumonia; postpandemic; proportion; respiratory; samples; sari; severe; surveillance; vidisca-454; viral; viruses; years
    • versions: original; plain text
35. cord-347200-dtwhd6zy
    • author: Ivanova, Daria
    • title: NK Cells in Mucosal Defense against Infection
    • date: 2014-08-14
    • words: 6965
    • flesch: 45
    • summary: IL-10 production by natural killer cells The aryl hydrocarbon receptor promotes IL-10 production by NK cells Adaptive immune features of natural killer cells Adaptive immune responses mediated by natural killer cells Natural killer (NK) and NKlike cells at mucosal epithelia: Mediators of anti-microbial defense and maintenance of tissue integrity Lymphoid microenvironments and innate lymphoid cells in the gut Location and cellular stages of natural killer cell development Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection Maturation of mouse NK cells is a 4-stage developmental program CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity Human natural killer cell development in secondary lymphoid tissues Tissueresident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells Lymphoid progenitors in normal mouse lymph nodes develop into NK cells and T cells in vitro and in vivo The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development Lamina propria ckit + immune precursors reside in human adult intestine and differentiate into natural killer cells Imbalance of NKp4 4+ NKp46 − and NKp44 − NKp46 + natural killer cells in the intestinal mucosa of patients with Crohn's disease IFN--producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response Origin, trafficking, and intraepithelial fate of gut-tropic T cells The light and dark sides of intestinal intraepithelial lymphocytes Organ-specific features of natural killer cells Natural killer cell distribution and trafficking in human tissues Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56 ℎ Biomed Res Int DOI: 10.1155/2014/413982 sha: doc_id: 347200 cord_uid: dtwhd6zy Conventional natural killer cells (NK cells) provide continual surveillance for cancer and rapid responses to infection.
    • keywords: activation; activity; bacterial; blood; bone; bright; cd11b; cd16; cd27; cd56; cells; control; conventional; critical; cytokine; cytolytic; defense; dependent; development; different; early; expansion; expression; female; function; gondii; gut; high; homing; human; ifn; il-15; immature; immune; immunity; important; infection; influenza; innate; intestinal; killer; lung; lymphocytes; lymphoid; marrow; mice; model; mouse; mucosal; murine; natural; nk cells; nkp46; parasitic; pathogens; peripheral; phenotype; populations; pregnancy; production; receptors; recruitment; resident; response; role; secondary; sites; specific; stages; state; studies; support; tissues; toxoplasma; tract; uterine; vaginal; viral; virus
    • versions: original; plain text
36. cord-351685-n70tkf38
    • author: Altamimi, Asmaa
    • title: Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
    • date: 2020-02-19
    • words: 3460
    • flesch: 52
    • summary: Similarly, two more single-centre case control studies reported that the presenting symptoms of MERS-CoV infection were not specific [18, 19] . Physicians and public health practitioners need to identify suspected cases which have higher chances of diagnosis as confirmed cases prior to laboratory testing (which usually takes between 12 and 24 hours). Therefore, the identification of suspected cases that may have higher chances of being diagnosed as cases of MERS-CoV is essential.
    • keywords: age; aged; analysis; arabia; authors; cases; clinical; confirmed; coronavirus; cov; data; days; demographic; descriptive; disease; east; factors; healthcare; help; higher; hospital; infection; laboratory; males; markers; mers; middle; patients; period; prevalence; qassim; regional; regions; respiratory; results; risk; riyadh; saudi; severe; significant; specific; studies; study; summer; syndrome; workers; years
    • versions: original; plain text
37. cord-352190-1987sfyz
    • author: Xia, Hongyue
    • title: Adaptive Evolution of Feline Coronavirus Genes Based on Selection Analysis
    • date: 2020-08-13
    • words: 4287
    • flesch: 48
    • summary: To amplify partial nsp12, nsp13, and nsp14 gene sequences, we designed primer pairs 1b3F and 1b1R and 1b6F and 1b6R. To amplify part of the N gene, primer pair N1 and N2 was used Of the 31 cats investigated, two suspected FIP cats and one healthy cat tested positive for FCoV. Phylogenetic analysis showed that all of the sequences from mainland China cluster together with a few sequences from the Netherlands as a distinct clade when analyzed with FCoV sequences from other countries.
    • keywords: adaptive; analysis; cats; china; coronavirus; countries; datamonkey; different; evidence; evolution; fcov; fcov sequences; fecv; feline; fipv; gene; genome; healthy; infectious; likelihood; methods; model; negative; negative selection; netherlands; nsp12; paml; peritonitis; phylogenetic; positive; positive selection; protein; ratio; recombination; rel; results; rna; s gene; samples; selection; selection sites; sequences; sites; study; table; type; united; viral; virulence; viruses
    • versions: original; plain text
38. cord-352231-awkkper2
    • author: Bakri, Faris Ghalib
    • title: The Highest Cited Papers in Brucellosis: Identification Using Two Databases and Review of the Papers' Major Findings
    • date: 2018-04-11
    • words: 2944
    • flesch: 48
    • summary: and its effectors The Brucella VirB Type IV Secretion System Human brucellosis The Two-component System BvrR/BvrS: a Master Regulator of Brucella Virulence Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature Present knowledge of brucellosis; a summary DNA genotyping suggests that recent brucellosis outbreaks in the greater yellowstone area originated from Elk Evaluation of a multilocus variable-number tandem-repeat analysis scheme for typing human Brucella isolates in a region of brucellosis endemicity Analysis of the 100 most-cited articles in periodontology The 100 most-cited original articles in cardiac computed tomography: A bibliometric analysis The Top 50 Articles on Minimally Invasive Spine Surgery An audit of top citations published in pediatric emergency care Coverage and quality: A comparison of Web of Science and Scopus databases for reporting faculty nursing publication metrics Comparison of PubMed, Scopus, Web of Science, and Google Scholar: Strengths and weaknesses Three options for citation tracking: Google Scholar, Scopus and Web of Science Top 100 cited articles in cardiovascular magnetic resonance: a bibliometric analysis Top-Cited Articles in Rehabilitation The Most Cited Papers in Osteoporosis and Related Research The Top 100 Cited Articles in Clinical Orthopedic Sports Medicine Bibliometric Analysis of the Top 100 Cited Cardiovascular Articles Citation Classics in Anesthetic Journals Citation classics in critical care medicine The most cited works in essential tremor and dystonia Citation classics in obstetrics and gynecology: the 100 most frequently cited journal articles in the last 50 years The seminal literature of anthrax research The highly cited SARS research literature Mapping the history and current situation of research on John Cunningham virus -A bibliometric analysis Citation Classics of Herpes Simplex Virus Tracing the scientific outputs in the field of Ebola research based on publications in the Web of Science Analysis of highly cited schistosomiasis related papers from The top cited clinical research articles on sepsis: a bibliometric analysis Bibliometric assessment of European and sub-Saharan African research output on poverty-related and neglected infectious diseases from Top-cited articles in digestive system disease from 1950 to 2013 Citation classics in chronic granulomatous disease: A bibliometric analysis Types of study in medical research: part 3 of a series on evaluation of scientific publications Evaluating research in cardiovascular medicine: Citation counts are not sufficient Brucella microti sp.
    • keywords: analysis; articles; assay; authors; basic; bibliometric; brucella; brucellosis; citation; citation classics; classics; clinical; count; countries; databases; disease; factor; field; highest; human; impact; journal; list; new; number; outbreaks; papers; position; recent; research; review; science; scopus; species; studies; study; system; title; type; virus; web; wos
    • versions: original; plain text
39. cord-354730-hfau2odb
    • author: Wang, Rong
    • title: Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus
    • date: 2014-07-03
    • words: 4940
    • flesch: 41
    • summary: Its nsp1 and nsp1 proteins should be able to inhibit IFN induction. Type II IFN contains only IFN-, whose production is restricted to activated T cells, natural killer cells, and macrophages
    • keywords: activation; activity; antiviral; cells; degradation; dendritic; different; domain; dsrna; effect; expression; host; ifn; ifns; immune; immunity; induced; induction; infected; infection; inhibit; inhibition; innate; interference; interferon; irf3; isg15; isgs; level; like; marc-145; mlv; nonstructural; nsp1; nsp2; nuclear; pathway; phosphorylation; pigs; porcine; production; protease; protein; prrsv; replication; reproductive; respiratory; respiratory syndrome; response; rig; signaling; stat1; strains; swine; syndrome; translocation; type; viral; virus; viruses
    • versions: original; plain text