id	sid	tid	token	lemma	pos
brj-24041	1	1	peer	peer	NOUN
brj-24041	1	2	-	-	PUNCT
brj-24041	1	3	review	review	NOUN
brj-24041	1	4	article	article	NOUN
brj-24041	1	5	peer	peer	NOUN
brj-24041	1	6	-	-	PUNCT
brj-24041	1	7	reviewed	review	VERB
brj-24041	1	8	article	article	NOUN
brj-24041	1	9	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	1	10	wang	wang	PROPN
brj-24041	1	11	et	et	PROPN
brj-24041	1	12	al	al	PROPN
brj-24041	1	13	.	.	PROPN
brj-24041	2	1	(	(	PUNCT
brj-24041	2	2	2025	2025	NUM
brj-24041	2	3	)	)	PUNCT
brj-24041	2	4	.	.	PUNCT
brj-24041	3	1	“	"	PUNCT
brj-24041	3	2	leaf	leaf	NOUN
brj-24041	3	3	extract	extract	VERB
brj-24041	3	4	anti	anti	ADJ
brj-24041	3	5	-	-	ADJ
brj-24041	3	6	inflammation	inflammation	ADJ
brj-24041	3	7	,	,	PUNCT
brj-24041	3	8	”	"	PUNCT
brj-24041	3	9	bioresources	bioresource	NOUN
brj-24041	3	10	20(1	20(1	NUM
brj-24041	3	11	)	)	PUNCT
brj-24041	3	12	,	,	PUNCT
brj-24041	3	13	956	956	NUM
brj-24041	3	14	-	-	SYM
brj-24041	3	15	971	971	NUM
brj-24041	3	16	.	.	PUNCT
brj-24041	4	1	956	956	NUM
brj-24041	4	2	anti	anti	ADJ
brj-24041	4	3	-	-	ADJ
brj-24041	4	4	inflammatory	inflammatory	ADJ
brj-24041	4	5	,	,	PUNCT
brj-24041	4	6	and	and	CCONJ
brj-24041	4	7	antioxidant	antioxidant	ADJ
brj-24041	4	8	effect	effect	NOUN
brj-24041	4	9	of	of	ADP
brj-24041	4	10	akebia	akebia	PROPN
brj-24041	4	11	quinata	quinata	PROPN
brj-24041	4	12	d.	d.	PROPN
brj-24041	4	13	leaves	leave	VERB
brj-24041	4	14	aqueous	aqueous	ADJ
brj-24041	4	15	extract	extract	NOUN
brj-24041	4	16	against	against	ADP
brj-24041	4	17	osteoarthritis	osteoarthritis	NOUN
brj-24041	4	18	in	in	ADP
brj-24041	4	19	mouse	mouse	NOUN
brj-24041	4	20	chondrocytes	chondrocyte	NOUN
brj-24041	4	21	and	and	CCONJ
brj-24041	4	22	in	in	ADP
brj-24041	4	23	rat	rat	NOUN
brj-24041	4	24	model	model	NOUN
brj-24041	4	25	of	of	ADP
brj-24041	4	26	osteoarthritis	osteoarthritis	NOUN
brj-24041	4	27	:	:	PUNCT
brj-24041	4	28	in	in	ADP
brj-24041	4	29	vitro	vitro	X
brj-24041	4	30	and	and	CCONJ
brj-24041	4	31	in	in	ADP
brj-24041	4	32	vivo	vivo	ADJ
brj-24041	4	33	studies	study	NOUN
brj-24041	4	34	panfeng	panfeng	PROPN
brj-24041	4	35	wang	wang	PROPN
brj-24041	4	36	,	,	PUNCT
brj-24041	4	37	a	a	DET
brj-24041	4	38	,	,	PUNCT
brj-24041	4	39	b	b	NOUN
brj-24041	4	40	,	,	PUNCT
brj-24041	4	41	#	#	NOUN
brj-24041	4	42	tongya	tongya	PROPN
brj-24041	4	43	guo	guo	PROPN
brj-24041	4	44	,	,	PUNCT
brj-24041	4	45	c	c	NOUN
brj-24041	4	46	,	,	PUNCT
brj-24041	4	47	#	#	NOUN
brj-24041	4	48	zhenwei	zhenwei	PROPN
brj-24041	4	49	tan	tan	PROPN
brj-24041	4	50	,	,	PUNCT
brj-24041	4	51	d	d	PROPN
brj-24041	4	52	and	and	CCONJ
brj-24041	4	53	feng	feng	PROPN
brj-24041	4	54	yuan	yuan	PROPN
brj-24041	4	55	e	e	PROPN
brj-24041	4	56	,	,	PUNCT
brj-24041	4	57	*	*	PUNCT
brj-24041	4	58	osteoarthritis	osteoarthritis	NOUN
brj-24041	4	59	(	(	PUNCT
brj-24041	4	60	oa	oa	NOUN
brj-24041	4	61	)	)	PUNCT
brj-24041	4	62	is	be	AUX
brj-24041	4	63	characterized	characterize	VERB
brj-24041	4	64	by	by	ADP
brj-24041	4	65	inflammation	inflammation	NOUN
brj-24041	4	66	of	of	ADP
brj-24041	4	67	the	the	DET
brj-24041	4	68	synovial	synovial	ADJ
brj-24041	4	69	joints	joint	NOUN
brj-24041	4	70	.	.	PUNCT
brj-24041	5	1	however	however	ADV
brj-24041	5	2	,	,	PUNCT
brj-24041	5	3	the	the	DET
brj-24041	5	4	drugs	drug	NOUN
brj-24041	5	5	used	use	VERB
brj-24041	5	6	to	to	PART
brj-24041	5	7	treat	treat	VERB
brj-24041	5	8	oa	oa	PROPN
brj-24041	5	9	are	be	AUX
brj-24041	5	10	insufficient	insufficient	ADJ
brj-24041	5	11	due	due	ADP
brj-24041	5	12	to	to	ADP
brj-24041	5	13	multifactorial	multifactorial	ADJ
brj-24041	5	14	pathogenesis	pathogenesis	NOUN
brj-24041	5	15	of	of	ADP
brj-24041	5	16	the	the	DET
brj-24041	5	17	disease	disease	NOUN
brj-24041	5	18	.	.	PUNCT
brj-24041	6	1	the	the	DET
brj-24041	6	2	present	present	ADJ
brj-24041	6	3	study	study	NOUN
brj-24041	6	4	determined	determine	VERB
brj-24041	6	5	the	the	DET
brj-24041	6	6	antiinflammatory	antiinflammatory	NOUN
brj-24041	6	7	and	and	CCONJ
brj-24041	6	8	antioxidant	antioxidant	ADJ
brj-24041	6	9	effect	effect	NOUN
brj-24041	6	10	of	of	ADP
brj-24041	6	11	akebia	akebia	PROPN
brj-24041	6	12	quinata	quinata	VERB
brj-24041	6	13	d.	d.	PROPN
brj-24041	6	14	aqueous	aqueous	PROPN
brj-24041	6	15	extract	extract	NOUN
brj-24041	6	16	(	(	PUNCT
brj-24041	6	17	aqde	aqde	ADV
brj-24041	6	18	)	)	PUNCT
brj-24041	6	19	against	against	ADP
brj-24041	6	20	osteoarthritis	osteoarthritis	NOUN
brj-24041	6	21	using	use	VERB
brj-24041	6	22	in	in	ADP
brj-24041	6	23	vitro	vitro	X
brj-24041	6	24	and	and	CCONJ
brj-24041	6	25	in	in	ADP
brj-24041	6	26	vivo	vivo	NOUN
brj-24041	6	27	models	model	NOUN
brj-24041	6	28	of	of	ADP
brj-24041	6	29	oa	oa	PROPN
brj-24041	6	30	.	.	PUNCT
brj-24041	6	31	initially	initially	ADV
brj-24041	6	32	,	,	PUNCT
brj-24041	6	33	the	the	DET
brj-24041	6	34	effect	effect	NOUN
brj-24041	6	35	of	of	ADP
brj-24041	6	36	aqde	aqde	ADV
brj-24041	6	37	was	be	AUX
brj-24041	6	38	identified	identify	VERB
brj-24041	6	39	to	to	PART
brj-24041	6	40	determine	determine	VERB
brj-24041	6	41	its	its	PRON
brj-24041	6	42	effect	effect	NOUN
brj-24041	6	43	on	on	ADP
brj-24041	6	44	the	the	DET
brj-24041	6	45	various	various	ADJ
brj-24041	6	46	biomarkers	biomarker	NOUN
brj-24041	6	47	of	of	ADP
brj-24041	6	48	the	the	DET
brj-24041	6	49	tnf	tnf	PROPN
brj-24041	6	50	-	-	PUNCT
brj-24041	6	51	α	α	PROPN
brj-24041	6	52	mouse	mouse	NOUN
brj-24041	6	53	chondrocytes	chondrocyte	NOUN
brj-24041	6	54	.	.	PUNCT
brj-24041	7	1	the	the	DET
brj-24041	7	2	results	result	NOUN
brj-24041	7	3	suggest	suggest	VERB
brj-24041	7	4	that	that	SCONJ
brj-24041	7	5	aqde	aqde	ADV
brj-24041	7	6	causes	cause	VERB
brj-24041	7	7	significant	significant	ADJ
brj-24041	7	8	acgan	acgan	ADJ
brj-24041	7	9	and	and	CCONJ
brj-24041	7	10	col2	col2	NOUN
brj-24041	7	11	and	and	CCONJ
brj-24041	7	12	reduction	reduction	NOUN
brj-24041	7	13	in	in	ADP
brj-24041	7	14	il-1b	il-1b	PROPN
brj-24041	7	15	,	,	PUNCT
brj-24041	7	16	il-6	il-6	PRON
brj-24041	7	17	,	,	PUNCT
brj-24041	7	18	mmp-13	mmp-13	PROPN
brj-24041	7	19	and	and	CCONJ
brj-24041	7	20	ptgs2	ptgs2	PROPN
brj-24041	7	21	.	.	PUNCT
brj-24041	8	1	it	it	PRON
brj-24041	8	2	also	also	ADV
brj-24041	8	3	causes	cause	VERB
brj-24041	8	4	induction	induction	NOUN
brj-24041	8	5	of	of	ADP
brj-24041	8	6	the	the	DET
brj-24041	8	7	expression	expression	NOUN
brj-24041	8	8	of	of	ADP
brj-24041	8	9	bcl2	bcl2	PROPN
brj-24041	8	10	,	,	PUNCT
brj-24041	8	11	cdk1	cdk1	PROPN
brj-24041	8	12	,	,	PUNCT
brj-24041	8	13	ccnd	ccnd	NOUN
brj-24041	8	14	,	,	PUNCT
brj-24041	8	15	and	and	CCONJ
brj-24041	8	16	reduction	reduction	NOUN
brj-24041	8	17	in	in	ADP
brj-24041	8	18	the	the	DET
brj-24041	8	19	rate	rate	NOUN
brj-24041	8	20	of	of	ADP
brj-24041	8	21	apoptosis	apoptosis	NOUN
brj-24041	8	22	of	of	ADP
brj-24041	8	23	mouse	mouse	NOUN
brj-24041	8	24	chondrocytes	chondrocyte	NOUN
brj-24041	8	25	.	.	PUNCT
brj-24041	9	1	in	in	ADP
brj-24041	9	2	the	the	DET
brj-24041	9	3	in	in	ADP
brj-24041	9	4	vivo	vivo	ADJ
brj-24041	9	5	rat	rat	NOUN
brj-24041	9	6	model	model	NOUN
brj-24041	9	7	,	,	PUNCT
brj-24041	9	8	aqde	aqde	ADV
brj-24041	9	9	improved	improve	VERB
brj-24041	9	10	mechanical	mechanical	ADJ
brj-24041	9	11	allodynia	allodynia	NOUN
brj-24041	9	12	in	in	ADP
brj-24041	9	13	the	the	DET
brj-24041	9	14	von	von	PROPN
brj-24041	9	15	frey	frey	PROPN
brj-24041	9	16	test	test	NOUN
brj-24041	9	17	and	and	CCONJ
brj-24041	9	18	reduced	reduce	VERB
brj-24041	9	19	knee	knee	NOUN
brj-24041	9	20	joint	joint	ADJ
brj-24041	9	21	swelling	swelling	NOUN
brj-24041	9	22	.	.	PUNCT
brj-24041	10	1	micro	micro	ADJ
brj-24041	10	2	-	-	NOUN
brj-24041	10	3	ct	ct	ADJ
brj-24041	10	4	scanning	scanning	NOUN
brj-24041	10	5	showed	show	VERB
brj-24041	10	6	improvement	improvement	NOUN
brj-24041	10	7	in	in	ADP
brj-24041	10	8	bone	bone	NOUN
brj-24041	10	9	erosion	erosion	NOUN
brj-24041	10	10	.	.	PUNCT
brj-24041	11	1	the	the	DET
brj-24041	11	2	level	level	NOUN
brj-24041	11	3	of	of	ADP
brj-24041	11	4	oxidative	oxidative	ADJ
brj-24041	11	5	stress	stress	NOUN
brj-24041	11	6	(	(	PUNCT
brj-24041	11	7	mda	mda	PROPN
brj-24041	11	8	,	,	PUNCT
brj-24041	11	9	sod	sod	NOUN
brj-24041	11	10	,	,	PUNCT
brj-24041	11	11	and	and	CCONJ
brj-24041	11	12	gsh	gsh	PROPN
brj-24041	11	13	)	)	PUNCT
brj-24041	11	14	and	and	CCONJ
brj-24041	11	15	production	production	NOUN
brj-24041	11	16	of	of	ADP
brj-24041	11	17	proinflammatory	proinflammatory	ADJ
brj-24041	11	18	cytokines	cytokine	NOUN
brj-24041	11	19	(	(	PUNCT
brj-24041	11	20	il-1b	il-1b	PROPN
brj-24041	11	21	,	,	PUNCT
brj-24041	11	22	and	and	CCONJ
brj-24041	11	23	il-6	il-6	NUM
brj-24041	11	24	)	)	PUNCT
brj-24041	11	25	was	be	AUX
brj-24041	11	26	restored	restore	VERB
brj-24041	11	27	to	to	ADP
brj-24041	11	28	near	near	ADJ
brj-24041	11	29	-	-	PUNCT
brj-24041	11	30	normal	normal	ADJ
brj-24041	11	31	levels	level	NOUN
brj-24041	11	32	in	in	ADP
brj-24041	11	33	a	a	DET
brj-24041	11	34	dose	dose	NOUN
brj-24041	11	35	-	-	PUNCT
brj-24041	11	36	dependent	dependent	ADJ
brj-24041	11	37	manner	manner	NOUN
brj-24041	11	38	.	.	PUNCT
brj-24041	12	1	aqde	aqde	ADV
brj-24041	12	2	reduced	reduce	VERB
brj-24041	12	3	the	the	DET
brj-24041	12	4	mrna	mrna	NOUN
brj-24041	12	5	expression	expression	NOUN
brj-24041	12	6	of	of	ADP
brj-24041	12	7	cox-2	cox-2	NUM
brj-24041	12	8	and	and	CCONJ
brj-24041	12	9	nf	nf	NOUN
brj-24041	12	10	-	-	PUNCT
brj-24041	12	11	kb	kb	NOUN
brj-24041	12	12	in	in	ADP
brj-24041	12	13	both	both	PRON
brj-24041	12	14	in	in	ADP
brj-24041	12	15	vitro	vitro	X
brj-24041	12	16	and	and	CCONJ
brj-24041	12	17	in	in	ADP
brj-24041	12	18	vivo	vivo	NOUN
brj-24041	12	19	study	study	NOUN
brj-24041	12	20	.	.	PUNCT
brj-24041	13	1	the	the	DET
brj-24041	13	2	results	result	NOUN
brj-24041	13	3	demonstrated	demonstrate	VERB
brj-24041	13	4	the	the	DET
brj-24041	13	5	significant	significant	ADJ
brj-24041	13	6	pharmacological	pharmacological	ADJ
brj-24041	13	7	activity	activity	NOUN
brj-24041	13	8	of	of	ADP
brj-24041	13	9	aqde	aqde	ADV
brj-24041	13	10	against	against	ADP
brj-24041	13	11	osteoarthritis	osteoarthritis	NOUN
brj-24041	13	12	in	in	ADP
brj-24041	13	13	both	both	CCONJ
brj-24041	13	14	in	in	ADP
brj-24041	13	15	vitro	vitro	X
brj-24041	13	16	and	and	CCONJ
brj-24041	13	17	in	in	ADP
brj-24041	13	18	vivo	vivo	NOUN
brj-24041	13	19	model	model	NOUN
brj-24041	13	20	.	.	PUNCT
brj-24041	14	1	doi	doi	NOUN
brj-24041	14	2	:	:	PUNCT
brj-24041	14	3	10.15376	10.15376	NUM
brj-24041	14	4	/	/	SYM
brj-24041	14	5	biores.20.1.956	biores.20.1.956	NUM
brj-24041	14	6	-	-	SYM
brj-24041	14	7	971	971	NUM
brj-24041	14	8	keywords	keyword	NOUN
brj-24041	14	9	:	:	PUNCT
brj-24041	14	10	inflammation	inflammation	NOUN
brj-24041	14	11	;	;	PUNCT
brj-24041	14	12	oxidative	oxidative	ADJ
brj-24041	14	13	stress	stress	NOUN
brj-24041	14	14	;	;	PUNCT
brj-24041	14	15	chondrocytes	chondrocyte	NOUN
brj-24041	14	16	;	;	PUNCT
brj-24041	14	17	knee	knee	NOUN
brj-24041	14	18	joint	joint	ADJ
brj-24041	14	19	swelling	swelling	NOUN
brj-24041	14	20	;	;	PUNCT
brj-24041	14	21	nf	nf	X
brj-24041	14	22	-	-	PUNCT
brj-24041	14	23	κb	κb	PROPN
brj-24041	14	24	contact	contact	NOUN
brj-24041	14	25	information	information	NOUN
brj-24041	14	26	:	:	PUNCT
brj-24041	14	27	a	a	DET
brj-24041	14	28	:	:	PUNCT
brj-24041	14	29	department	department	NOUN
brj-24041	14	30	of	of	ADP
brj-24041	14	31	orthopedics	orthopedic	NOUN
brj-24041	14	32	,	,	PUNCT
brj-24041	14	33	the	the	DET
brj-24041	14	34	second	second	ADJ
brj-24041	14	35	affiliated	affiliated	ADJ
brj-24041	14	36	hospital	hospital	NOUN
brj-24041	14	37	of	of	ADP
brj-24041	14	38	soochow	soochow	PROPN
brj-24041	14	39	university	university	PROPN
brj-24041	14	40	,	,	PUNCT
brj-24041	14	41	suzhou	suzhou	PROPN
brj-24041	14	42	jiangsu	jiangsu	PROPN
brj-24041	14	43	,	,	PUNCT
brj-24041	14	44	524088	524088	NUM
brj-24041	14	45	,	,	PUNCT
brj-24041	14	46	china	china	PROPN
brj-24041	14	47	;	;	PUNCT
brj-24041	14	48	b	b	X
brj-24041	14	49	:	:	PUNCT
brj-24041	14	50	department	department	NOUN
brj-24041	14	51	of	of	ADP
brj-24041	14	52	trauma	trauma	NOUN
brj-24041	14	53	orthopedics	orthopedic	NOUN
brj-24041	14	54	,	,	PUNCT
brj-24041	14	55	changhai	changhai	NOUN
brj-24041	14	56	hospital	hospital	NOUN
brj-24041	14	57	,	,	PUNCT
brj-24041	14	58	shanghai	shanghai	PROPN
brj-24041	14	59	,	,	PUNCT
brj-24041	14	60	200433	200433	NUM
brj-24041	14	61	,	,	PUNCT
brj-24041	14	62	china	china	PROPN
brj-24041	14	63	;	;	PUNCT
brj-24041	14	64	c	c	X
brj-24041	14	65	:	:	PUNCT
brj-24041	14	66	department	department	NOUN
brj-24041	14	67	of	of	ADP
brj-24041	14	68	bone	bone	NOUN
brj-24041	14	69	and	and	CCONJ
brj-24041	14	70	joint	joint	ADJ
brj-24041	14	71	surgery	surgery	NOUN
brj-24041	14	72	,	,	PUNCT
brj-24041	14	73	xuzhou	xuzhou	PROPN
brj-24041	14	74	central	central	PROPN
brj-24041	14	75	hospital	hospital	PROPN
brj-24041	14	76	,	,	PUNCT
brj-24041	14	77	xuzhou	xuzhou	PROPN
brj-24041	14	78	jiangsu	jiangsu	PROPN
brj-24041	14	79	,	,	PUNCT
brj-24041	14	80	221009,china	221009,china	NUM
brj-24041	14	81	;	;	PUNCT
brj-24041	14	82	d	d	X
brj-24041	14	83	:	:	PUNCT
brj-24041	14	84	department	department	NOUN
brj-24041	14	85	of	of	ADP
brj-24041	14	86	orthopedics	orthopedic	NOUN
brj-24041	14	87	,	,	PUNCT
brj-24041	14	88	sichuan	sichuan	PROPN
brj-24041	14	89	fifth	fifth	ADJ
brj-24041	14	90	people	people	NOUN
brj-24041	14	91	's	's	PART
brj-24041	14	92	hospital	hospital	NOUN
brj-24041	14	93	,	,	PUNCT
brj-24041	14	94	sichuan	sichuan	PROPN
brj-24041	14	95	chengdu	chengdu	PROPN
brj-24041	14	96	,	,	PUNCT
brj-24041	14	97	610015	610015	NUM
brj-24041	14	98	,	,	PUNCT
brj-24041	14	99	china	china	PROPN
brj-24041	14	100	;	;	PUNCT
brj-24041	14	101	e	e	X
brj-24041	14	102	:	:	PUNCT
brj-24041	14	103	department	department	NOUN
brj-24041	14	104	of	of	ADP
brj-24041	14	105	orthopaedic	orthopaedic	ADJ
brj-24041	14	106	surgery	surgery	NOUN
brj-24041	14	107	,	,	PUNCT
brj-24041	14	108	shanghai	shanghai	PROPN
brj-24041	14	109	sixth	sixth	ADJ
brj-24041	14	110	people	people	NOUN
brj-24041	14	111	's	's	PART
brj-24041	14	112	hospital	hospital	NOUN
brj-24041	14	113	affiliated	affiliate	VERB
brj-24041	14	114	to	to	ADP
brj-24041	14	115	shanghai	shanghai	PROPN
brj-24041	14	116	jiao	jiao	PROPN
brj-24041	14	117	tong	tong	PROPN
brj-24041	14	118	university	university	PROPN
brj-24041	14	119	school	school	NOUN
brj-24041	14	120	of	of	ADP
brj-24041	14	121	medicine	medicine	NOUN
brj-24041	14	122	,	,	PUNCT
brj-24041	14	123	shanghai	shanghai	PROPN
brj-24041	14	124	,	,	PUNCT
brj-24041	14	125	200233	200233	NUM
brj-24041	14	126	,	,	PUNCT
brj-24041	14	127	china	china	PROPN
brj-24041	14	128	;	;	PUNCT
brj-24041	14	129	*	*	PUNCT
brj-24041	14	130	corresponding	correspond	VERB
brj-24041	14	131	author	author	NOUN
brj-24041	14	132	:	:	PUNCT
brj-24041	14	133	yuanfeng202466@outlook.com	yuanfeng202466@outlook.com	PROPN
brj-24041	14	134	;	;	PUNCT
brj-24041	14	135	#	#	ADV
brj-24041	14	136	:	:	PUNCT
brj-24041	14	137	contributed	contribute	VERB
brj-24041	14	138	equally	equally	ADV
brj-24041	14	139	introduction	introduction	NOUN
brj-24041	14	140	osteoarthritis	osteoarthritis	NOUN
brj-24041	14	141	(	(	PUNCT
brj-24041	14	142	oa	oa	X
brj-24041	14	143	)	)	PUNCT
brj-24041	14	144	is	be	AUX
brj-24041	14	145	a	a	DET
brj-24041	14	146	common	common	ADJ
brj-24041	14	147	disorder	disorder	NOUN
brj-24041	14	148	of	of	ADP
brj-24041	14	149	the	the	DET
brj-24041	14	150	bones	bone	NOUN
brj-24041	14	151	and	and	CCONJ
brj-24041	14	152	joints	joint	NOUN
brj-24041	14	153	that	that	PRON
brj-24041	14	154	is	be	AUX
brj-24041	14	155	characterized	characterize	VERB
brj-24041	14	156	by	by	ADP
brj-24041	14	157	inflammation	inflammation	NOUN
brj-24041	14	158	of	of	ADP
brj-24041	14	159	the	the	DET
brj-24041	14	160	synovial	synovial	ADJ
brj-24041	14	161	joints	joint	NOUN
brj-24041	14	162	,	,	PUNCT
brj-24041	14	163	sclerosis	sclerosis	NOUN
brj-24041	14	164	of	of	ADP
brj-24041	14	165	the	the	DET
brj-24041	14	166	subchondral	subchondral	ADJ
brj-24041	14	167	bone	bone	NOUN
brj-24041	14	168	,	,	PUNCT
brj-24041	14	169	and	and	CCONJ
brj-24041	14	170	chronic	chronic	ADJ
brj-24041	14	171	degradation	degradation	NOUN
brj-24041	14	172	of	of	ADP
brj-24041	14	173	articular	articular	ADJ
brj-24041	14	174	cartilage	cartilage	NOUN
brj-24041	14	175	(	(	PUNCT
brj-24041	14	176	sun	sun	NOUN
brj-24041	14	177	et	et	PROPN
brj-24041	14	178	al	al	PROPN
brj-24041	14	179	.	.	PROPN
brj-24041	14	180	2019b	2019b	NUM
brj-24041	14	181	)	)	PUNCT
brj-24041	14	182	.	.	PUNCT
brj-24041	15	1	the	the	DET
brj-24041	15	2	repercussions	repercussion	NOUN
brj-24041	15	3	include	include	VERB
brj-24041	15	4	impairments	impairment	NOUN
brj-24041	15	5	and	and	CCONJ
brj-24041	15	6	restrictions	restriction	NOUN
brj-24041	15	7	on	on	ADP
brj-24041	15	8	one	one	NUM
brj-24041	15	9	’s	’s	PART
brj-24041	15	10	own	own	ADJ
brj-24041	15	11	activities	activity	NOUN
brj-24041	15	12	,	,	PUNCT
brj-24041	15	13	in	in	ADP
brj-24041	15	14	addition	addition	NOUN
brj-24041	15	15	to	to	ADP
brj-24041	15	16	having	have	VERB
brj-24041	15	17	a	a	DET
brj-24041	15	18	big	big	ADJ
brj-24041	15	19	financial	financial	ADJ
brj-24041	15	20	impact	impact	NOUN
brj-24041	15	21	on	on	ADP
brj-24041	15	22	the	the	DET
brj-24041	15	23	entire	entire	ADJ
brj-24041	15	24	world	world	NOUN
brj-24041	15	25	(	(	PUNCT
brj-24041	15	26	wood	wood	NOUN
brj-24041	15	27	et	et	PROPN
brj-24041	15	28	al	al	PROPN
brj-24041	15	29	.	.	PROPN
brj-24041	15	30	2022	2022	NUM
brj-24041	15	31	)	)	PUNCT
brj-24041	15	32	.	.	PUNCT
brj-24041	16	1	numerous	numerous	ADJ
brj-24041	16	2	factors	factor	NOUN
brj-24041	16	3	,	,	PUNCT
brj-24041	16	4	such	such	ADJ
brj-24041	16	5	as	as	ADP
brj-24041	16	6	age	age	NOUN
brj-24041	16	7	,	,	PUNCT
brj-24041	16	8	weight	weight	NOUN
brj-24041	16	9	,	,	PUNCT
brj-24041	16	10	genetic	genetic	ADJ
brj-24041	16	11	inheritance	inheritance	NOUN
brj-24041	16	12	,	,	PUNCT
brj-24041	16	13	and	and	CCONJ
brj-24041	16	14	prior	prior	ADJ
brj-24041	16	15	joint	joint	ADJ
brj-24041	16	16	damage	damage	NOUN
brj-24041	16	17	or	or	CCONJ
brj-24041	16	18	deformity	deformity	NOUN
brj-24041	16	19	,	,	PUNCT
brj-24041	16	20	increase	increase	VERB
brj-24041	16	21	the	the	DET
brj-24041	16	22	chance	chance	NOUN
brj-24041	16	23	of	of	ADP
brj-24041	16	24	developing	develop	VERB
brj-24041	16	25	osteoarthritis	osteoarthritis	NOUN
brj-24041	16	26	(	(	PUNCT
brj-24041	16	27	oa	oa	NOUN
brj-24041	16	28	)	)	PUNCT
brj-24041	16	29	.	.	PUNCT
brj-24041	17	1	chondrocytes	chondrocyte	NOUN
brj-24041	17	2	are	be	AUX
brj-24041	17	3	the	the	DET
brj-24041	17	4	only	only	ADJ
brj-24041	17	5	cells	cell	NOUN
brj-24041	17	6	found	find	VERB
brj-24041	17	7	in	in	ADP
brj-24041	17	8	articular	articular	ADJ
brj-24041	17	9	cartilage	cartilage	NOUN
brj-24041	17	10	,	,	PUNCT
brj-24041	17	11	and	and	CCONJ
brj-24041	17	12	the	the	DET
brj-24041	17	13	stability	stability	NOUN
brj-24041	17	14	of	of	ADP
brj-24041	17	15	the	the	DET
brj-24041	17	16	cartilage	cartilage	NOUN
brj-24041	17	17	depends	depend	VERB
brj-24041	17	18	on	on	ADP
brj-24041	17	19	their	their	PRON
brj-24041	17	20	complex	complex	ADJ
brj-24041	17	21	biosynthetic	biosynthetic	ADJ
brj-24041	17	22	activities	activity	NOUN
brj-24041	17	23	.	.	PUNCT
brj-24041	18	1	secondary	secondary	ADJ
brj-24041	18	2	data	datum	NOUN
brj-24041	18	3	suggests	suggest	VERB
brj-24041	18	4	that	that	SCONJ
brj-24041	18	5	the	the	DET
brj-24041	18	6	degeneration	degeneration	NOUN
brj-24041	18	7	of	of	ADP
brj-24041	18	8	cartilage	cartilage	NOUN
brj-24041	18	9	is	be	AUX
brj-24041	18	10	brought	bring	VERB
brj-24041	18	11	on	on	ADP
brj-24041	18	12	by	by	ADP
brj-24041	18	13	chondrocyte	chondrocyte	NOUN
brj-24041	18	14	mortality	mortality	NOUN
brj-24041	18	15	as	as	ADP
brj-24041	18	16	a	a	DET
brj-24041	18	17	https://orcid.org/0009-0006-2687-1252	https://orcid.org/0009-0006-2687-1252	NOUN
brj-24041	18	18	https://orcid.org/0009-0003-5563-8589	https://orcid.org/0009-0003-5563-8589	NOUN
brj-24041	18	19	https://orcid.org/0009-0002-3043-5331	https://orcid.org/0009-0002-3043-5331	ADV
brj-24041	18	20	https://orcid.org/0000-0002-3694-1617	https://orcid.org/0000-0002-3694-1617	PROPN
brj-24041	18	21	peer	peer	NOUN
brj-24041	18	22	-	-	PUNCT
brj-24041	18	23	reviewed	review	VERB
brj-24041	18	24	article	article	NOUN
brj-24041	18	25	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	18	26	wang	wang	PROPN
brj-24041	18	27	et	et	PROPN
brj-24041	18	28	al	al	PROPN
brj-24041	18	29	.	.	PROPN
brj-24041	19	1	(	(	PUNCT
brj-24041	19	2	2025	2025	NUM
brj-24041	19	3	)	)	PUNCT
brj-24041	19	4	.	.	PUNCT
brj-24041	20	1	“	"	PUNCT
brj-24041	20	2	leaf	leaf	NOUN
brj-24041	20	3	extract	extract	VERB
brj-24041	20	4	anti	anti	ADJ
brj-24041	20	5	-	-	ADJ
brj-24041	20	6	inflammation	inflammation	ADJ
brj-24041	20	7	,	,	PUNCT
brj-24041	20	8	”	"	PUNCT
brj-24041	20	9	bioresources	bioresource	NOUN
brj-24041	20	10	20(1	20(1	NUM
brj-24041	20	11	)	)	PUNCT
brj-24041	20	12	,	,	PUNCT
brj-24041	20	13	956	956	NUM
brj-24041	20	14	-	-	SYM
brj-24041	20	15	971	971	NUM
brj-24041	20	16	.	.	PUNCT
brj-24041	21	1	957	957	NUM
brj-24041	21	2	consequence	consequence	NOUN
brj-24041	21	3	of	of	ADP
brj-24041	21	4	pro	pro	ADJ
brj-24041	21	5	-	-	ADJ
brj-24041	21	6	inflammatory	inflammatory	ADJ
brj-24041	21	7	cytokine	cytokine	NOUN
brj-24041	21	8	release	release	NOUN
brj-24041	21	9	,	,	PUNCT
brj-24041	21	10	such	such	ADJ
brj-24041	21	11	as	as	ADP
brj-24041	21	12	tnf	tnf	PROPN
brj-24041	21	13	-	-	PUNCT
brj-24041	21	14	α	α	PROPN
brj-24041	21	15	and	and	CCONJ
brj-24041	21	16	interleukin-1β	interleukin-1β	PROPN
brj-24041	21	17	(	(	PUNCT
brj-24041	21	18	il1β	il1β	PROPN
brj-24041	21	19	)	)	PUNCT
brj-24041	21	20	(	(	PUNCT
brj-24041	21	21	katturajan	katturajan	ADJ
brj-24041	21	22	and	and	CCONJ
brj-24041	21	23	sabina	sabina	NOUN
brj-24041	21	24	2021	2021	NUM
brj-24041	21	25	)	)	PUNCT
brj-24041	21	26	.	.	PUNCT
brj-24041	22	1	according	accord	VERB
brj-24041	22	2	to	to	ADP
brj-24041	22	3	experimental	experimental	ADJ
brj-24041	22	4	data	datum	NOUN
brj-24041	22	5	,	,	PUNCT
brj-24041	22	6	chondrocytes	chondrocyte	NOUN
brj-24041	22	7	can	can	AUX
brj-24041	22	8	be	be	AUX
brj-24041	22	9	directly	directly	ADV
brj-24041	22	10	stimulated	stimulate	VERB
brj-24041	22	11	by	by	ADP
brj-24041	22	12	inflammation	inflammation	NOUN
brj-24041	22	13	cytokines	cytokine	NOUN
brj-24041	22	14	to	to	PART
brj-24041	22	15	secrete	secrete	VERB
brj-24041	22	16	catabolic	catabolic	ADJ
brj-24041	22	17	enzymes	enzyme	NOUN
brj-24041	22	18	that	that	PRON
brj-24041	22	19	aid	aid	NOUN
brj-24041	22	20	in	in	ADP
brj-24041	22	21	the	the	DET
brj-24041	22	22	breakdown	breakdown	NOUN
brj-24041	22	23	of	of	ADP
brj-24041	22	24	the	the	DET
brj-24041	22	25	extracellular	extracellular	ADJ
brj-24041	22	26	matrix	matrix	NOUN
brj-24041	22	27	(	(	PUNCT
brj-24041	22	28	ecm	ecm	PROPN
brj-24041	22	29	)	)	PUNCT
brj-24041	22	30	,	,	PUNCT
brj-24041	22	31	such	such	ADJ
brj-24041	22	32	as	as	ADP
brj-24041	22	33	matrix	matrix	NOUN
brj-24041	22	34	metalloproteinases	metalloproteinase	NOUN
brj-24041	22	35	(	(	PUNCT
brj-24041	22	36	mmps	mmp	NOUN
brj-24041	22	37	)	)	PUNCT
brj-24041	22	38	and	and	CCONJ
brj-24041	22	39	a	a	DET
brj-24041	22	40	disintegrin	disintegrin	NOUN
brj-24041	22	41	and	and	CCONJ
brj-24041	22	42	metalloproteinase	metalloproteinase	NOUN
brj-24041	22	43	with	with	ADP
brj-24041	22	44	thrombospondin	thrombospondin	VERB
brj-24041	22	45	motifs	motif	NOUN
brj-24041	22	46	(	(	PUNCT
brj-24041	22	47	adamts	adamts	PROPN
brj-24041	22	48	)	)	PUNCT
brj-24041	22	49	(	(	PUNCT
brj-24041	22	50	eccleston	eccleston	PROPN
brj-24041	22	51	2023	2023	NUM
brj-24041	22	52	)	)	PUNCT
brj-24041	22	53	.	.	PUNCT
brj-24041	23	1	furthermore	furthermore	ADV
brj-24041	23	2	,	,	PUNCT
brj-24041	23	3	prior	prior	ADJ
brj-24041	23	4	research	research	NOUN
brj-24041	23	5	has	have	AUX
brj-24041	23	6	demonstrated	demonstrate	VERB
brj-24041	23	7	that	that	SCONJ
brj-24041	23	8	chondrocyte	chondrocyte	PROPN
brj-24041	23	9	survival	survival	NOUN
brj-24041	23	10	is	be	AUX
brj-24041	23	11	significantly	significantly	ADV
brj-24041	23	12	impacted	impact	VERB
brj-24041	23	13	by	by	ADP
brj-24041	23	14	persistently	persistently	ADV
brj-24041	23	15	elevated	elevate	VERB
brj-24041	23	16	levels	level	NOUN
brj-24041	23	17	of	of	ADP
brj-24041	23	18	tnf	tnf	PROPN
brj-24041	23	19	-	-	PUNCT
brj-24041	23	20	α	α	PROPN
brj-24041	23	21	and	and	CCONJ
brj-24041	23	22	il-1β	il-1β	PROPN
brj-24041	23	23	.	.	PUNCT
brj-24041	24	1	the	the	DET
brj-24041	24	2	continuous	continuous	ADJ
brj-24041	24	3	inflammatory	inflammatory	ADJ
brj-24041	24	4	processes	process	NOUN
brj-24041	24	5	prevent	prevent	VERB
brj-24041	24	6	proliferative	proliferative	ADJ
brj-24041	24	7	chondrocytes	chondrocyte	NOUN
brj-24041	24	8	from	from	ADP
brj-24041	24	9	developing	develop	VERB
brj-24041	24	10	in	in	ADP
brj-24041	24	11	the	the	DET
brj-24041	24	12	cartilage	cartilage	NOUN
brj-24041	24	13	tissue	tissue	NOUN
brj-24041	24	14	,	,	PUNCT
brj-24041	24	15	which	which	PRON
brj-24041	24	16	makes	make	VERB
brj-24041	24	17	it	it	PRON
brj-24041	24	18	unable	unable	ADJ
brj-24041	24	19	to	to	PART
brj-24041	24	20	repair	repair	VERB
brj-24041	24	21	the	the	DET
brj-24041	24	22	injured	injured	ADJ
brj-24041	24	23	cartilage	cartilage	NOUN
brj-24041	24	24	tissue	tissue	NOUN
brj-24041	24	25	.	.	PUNCT
brj-24041	25	1	thus	thus	ADV
brj-24041	25	2	,	,	PUNCT
brj-24041	25	3	degenerative	degenerative	ADJ
brj-24041	25	4	arthritis	arthritis	NOUN
brj-24041	25	5	gets	get	VERB
brj-24041	25	6	worse	bad	ADJ
brj-24041	25	7	as	as	ADP
brj-24041	25	8	a	a	DET
brj-24041	25	9	result	result	NOUN
brj-24041	25	10	of	of	ADP
brj-24041	25	11	this	this	DET
brj-24041	25	12	process	process	NOUN
brj-24041	25	13	(	(	PUNCT
brj-24041	25	14	thudium	thudium	NOUN
brj-24041	25	15	et	et	PROPN
brj-24041	25	16	al	al	PROPN
brj-24041	25	17	.	.	PROPN
brj-24041	25	18	2019	2019	NUM
brj-24041	25	19	)	)	PUNCT
brj-24041	25	20	.	.	PUNCT
brj-24041	26	1	therefore	therefore	ADV
brj-24041	26	2	,	,	PUNCT
brj-24041	26	3	inhibiting	inhibit	VERB
brj-24041	26	4	these	these	DET
brj-24041	26	5	inflammatory	inflammatory	ADJ
brj-24041	26	6	reactions	reaction	NOUN
brj-24041	26	7	could	could	AUX
brj-24041	26	8	slow	slow	VERB
brj-24041	26	9	the	the	DET
brj-24041	26	10	progression	progression	NOUN
brj-24041	26	11	of	of	ADP
brj-24041	26	12	osteoarthritis	osteoarthritis	NOUN
brj-24041	26	13	.	.	PUNCT
brj-24041	27	1	contemporary	contemporary	ADJ
brj-24041	27	2	therapy	therapy	NOUN
brj-24041	27	3	for	for	ADP
brj-24041	27	4	osteoarthritis	osteoarthritis	NOUN
brj-24041	27	5	(	(	PUNCT
brj-24041	27	6	oa	oa	NOUN
brj-24041	27	7	)	)	PUNCT
brj-24041	27	8	mostly	mostly	ADV
brj-24041	27	9	involves	involve	VERB
brj-24041	27	10	the	the	DET
brj-24041	27	11	use	use	NOUN
brj-24041	27	12	of	of	ADP
brj-24041	27	13	glucocorticoids	glucocorticoid	NOUN
brj-24041	27	14	and	and	CCONJ
brj-24041	27	15	non	non	ADJ
brj-24041	27	16	-	-	ADJ
brj-24041	27	17	steroidal	steroidal	ADJ
brj-24041	27	18	anti	anti	ADJ
brj-24041	27	19	-	-	ADJ
brj-24041	27	20	inflammatory	inflammatory	ADJ
brj-24041	27	21	medications	medication	NOUN
brj-24041	27	22	(	(	PUNCT
brj-24041	27	23	nsaids	nsaid	NOUN
brj-24041	27	24	)	)	PUNCT
brj-24041	27	25	,	,	PUNCT
brj-24041	27	26	which	which	PRON
brj-24041	27	27	suppress	suppress	VERB
brj-24041	27	28	the	the	DET
brj-24041	27	29	mechanisms	mechanism	NOUN
brj-24041	27	30	responsible	responsible	ADJ
brj-24041	27	31	for	for	ADP
brj-24041	27	32	inflammatory	inflammatory	ADJ
brj-24041	27	33	responses	response	NOUN
brj-24041	27	34	(	(	PUNCT
brj-24041	27	35	grässel	grässel	NOUN
brj-24041	27	36	and	and	CCONJ
brj-24041	27	37	muschter	muschter	NOUN
brj-24041	27	38	2020	2020	NUM
brj-24041	27	39	;	;	PUNCT
brj-24041	27	40	lin	lin	PROPN
brj-24041	27	41	et	et	PROPN
brj-24041	27	42	al	al	PROPN
brj-24041	27	43	.	.	PROPN
brj-24041	27	44	2023	2023	NUM
brj-24041	27	45	)	)	PUNCT
brj-24041	27	46	.	.	PUNCT
brj-24041	28	1	nevertheless	nevertheless	ADV
brj-24041	28	2	,	,	PUNCT
brj-24041	28	3	these	these	DET
brj-24041	28	4	drugs	drug	NOUN
brj-24041	28	5	are	be	AUX
brj-24041	28	6	unable	unable	ADJ
brj-24041	28	7	to	to	PART
brj-24041	28	8	change	change	VERB
brj-24041	28	9	the	the	DET
brj-24041	28	10	pattern	pattern	NOUN
brj-24041	28	11	of	of	ADP
brj-24041	28	12	disease	disease	NOUN
brj-24041	28	13	development	development	NOUN
brj-24041	28	14	.	.	PUNCT
brj-24041	29	1	in	in	ADP
brj-24041	29	2	addition	addition	NOUN
brj-24041	29	3	,	,	PUNCT
brj-24041	29	4	these	these	DET
brj-24041	29	5	drugs	drug	NOUN
brj-24041	29	6	have	have	VERB
brj-24041	29	7	too	too	ADV
brj-24041	29	8	much	much	ADJ
brj-24041	29	9	linkage	linkage	NOUN
brj-24041	29	10	to	to	ADP
brj-24041	29	11	significant	significant	ADJ
brj-24041	29	12	adverse	adverse	ADJ
brj-24041	29	13	effects	effect	NOUN
brj-24041	29	14	when	when	SCONJ
brj-24041	29	15	used	use	VERB
brj-24041	29	16	for	for	ADP
brj-24041	29	17	an	an	DET
brj-24041	29	18	extended	extended	ADJ
brj-24041	29	19	period	period	NOUN
brj-24041	29	20	.	.	PUNCT
brj-24041	30	1	multiple	multiple	ADJ
brj-24041	30	2	studies	study	NOUN
brj-24041	30	3	have	have	AUX
brj-24041	30	4	documented	document	VERB
brj-24041	30	5	the	the	DET
brj-24041	30	6	therapeutic	therapeutic	ADJ
brj-24041	30	7	advantages	advantage	NOUN
brj-24041	30	8	of	of	ADP
brj-24041	30	9	certain	certain	ADJ
brj-24041	30	10	traditional	traditional	ADJ
brj-24041	30	11	chinese	chinese	ADJ
brj-24041	30	12	herbs	herb	NOUN
brj-24041	30	13	in	in	ADP
brj-24041	30	14	reducing	reduce	VERB
brj-24041	30	15	the	the	DET
brj-24041	30	16	effects	effect	NOUN
brj-24041	30	17	of	of	ADP
brj-24041	30	18	osteoarthritis	osteoarthritis	NOUN
brj-24041	30	19	(	(	PUNCT
brj-24041	30	20	oa	oa	NOUN
brj-24041	30	21	)	)	PUNCT
brj-24041	30	22	by	by	ADP
brj-24041	30	23	inhibiting	inhibit	VERB
brj-24041	30	24	the	the	DET
brj-24041	30	25	functioning	functioning	NOUN
brj-24041	30	26	of	of	ADP
brj-24041	30	27	matrix	matrix	NOUN
brj-24041	30	28	metalloproteinases	metalloproteinase	NOUN
brj-24041	30	29	(	(	PUNCT
brj-24041	30	30	mmps	mmp	NOUN
brj-24041	30	31	)	)	PUNCT
brj-24041	30	32	and	and	CCONJ
brj-24041	30	33	interleukins	interleukin	NOUN
brj-24041	30	34	(	(	PUNCT
brj-24041	30	35	ils	ils	NOUN
brj-24041	30	36	)	)	PUNCT
brj-24041	30	37	,	,	PUNCT
brj-24041	30	38	hence	hence	ADV
brj-24041	30	39	effectively	effectively	ADV
brj-24041	30	40	reducing	reduce	VERB
brj-24041	30	41	oa	oa	PRON
brj-24041	30	42	generated	generate	VERB
brj-24041	30	43	by	by	ADP
brj-24041	30	44	monosodium	monosodium	NOUN
brj-24041	30	45	iodoacetate	iodoacetate	NOUN
brj-24041	30	46	(	(	PUNCT
brj-24041	30	47	mia	mia	NOUN
brj-24041	30	48	)	)	PUNCT
brj-24041	30	49	(	(	PUNCT
brj-24041	30	50	lee	lee	PROPN
brj-24041	30	51	et	et	PROPN
brj-24041	30	52	al	al	PROPN
brj-24041	30	53	.	.	PROPN
brj-24041	30	54	2022b	2022b	NUM
brj-24041	30	55	)	)	PUNCT
brj-24041	30	56	.	.	PUNCT
brj-24041	31	1	the	the	DET
brj-24041	31	2	creeping	creep	VERB
brj-24041	31	3	woody	woody	NOUN
brj-24041	31	4	vine	vine	NOUN
brj-24041	31	5	akebia	akebia	PROPN
brj-24041	31	6	quinata	quinata	ADJ
brj-24041	31	7	decaisne	decaisne	NOUN
brj-24041	31	8	(	(	PUNCT
brj-24041	31	9	lardizabalaceae	lardizabalaceae	PROPN
brj-24041	31	10	)	)	PUNCT
brj-24041	31	11	is	be	AUX
brj-24041	31	12	extensively	extensively	ADV
brj-24041	31	13	found	find	VERB
brj-24041	31	14	in	in	ADP
brj-24041	31	15	east	east	PROPN
brj-24041	31	16	asia	asia	PROPN
brj-24041	31	17	,	,	PUNCT
brj-24041	31	18	encompassing	encompass	VERB
brj-24041	31	19	korea	korea	PROPN
brj-24041	31	20	,	,	PUNCT
brj-24041	31	21	china	china	PROPN
brj-24041	31	22	,	,	PUNCT
brj-24041	31	23	and	and	CCONJ
brj-24041	31	24	japan	japan	PROPN
brj-24041	31	25	(	(	PUNCT
brj-24041	31	26	scholler	scholler	NOUN
brj-24041	31	27	and	and	CCONJ
brj-24041	31	28	gams	gam	NOUN
brj-24041	31	29	1998	1998	NUM
brj-24041	31	30	;	;	PUNCT
brj-24041	31	31	“	"	PUNCT
brj-24041	31	32	akebia	akebia	PROPN
brj-24041	31	33	quinata	quinata	VERB
brj-24041	31	34	(	(	PUNCT
brj-24041	31	35	five	five	NUM
brj-24041	31	36	-	-	PUNCT
brj-24041	31	37	leaf	leaf	NOUN
brj-24041	31	38	akebia	akebia	NOUN
brj-24041	31	39	)	)	PUNCT
brj-24041	31	40	”	"	PUNCT
brj-24041	31	41	2022	2022	NUM
brj-24041	31	42	)	)	PUNCT
brj-24041	31	43	.	.	PUNCT
brj-24041	32	1	historically	historically	ADV
brj-24041	32	2	,	,	PUNCT
brj-24041	32	3	the	the	DET
brj-24041	32	4	extract	extract	NOUN
brj-24041	32	5	of	of	ADP
brj-24041	32	6	a.	a.	NOUN
brj-24041	32	7	quinata	quinata	PROPN
brj-24041	32	8	decaisne	decaisne	NOUN
brj-24041	32	9	(	(	PUNCT
brj-24041	32	10	aqe	aqe	PROPN
brj-24041	32	11	)	)	PUNCT
brj-24041	32	12	has	have	AUX
brj-24041	32	13	been	be	AUX
brj-24041	32	14	suggested	suggest	VERB
brj-24041	32	15	to	to	PART
brj-24041	32	16	alleviate	alleviate	VERB
brj-24041	32	17	heat	heat	NOUN
brj-24041	32	18	caused	cause	VERB
brj-24041	32	19	by	by	ADP
brj-24041	32	20	stress	stress	NOUN
brj-24041	32	21	and	and	CCONJ
brj-24041	32	22	fatigue	fatigue	NOUN
brj-24041	32	23	-	-	PUNCT
brj-24041	32	24	induced	induce	VERB
brj-24041	32	25	depression	depression	NOUN
brj-24041	32	26	,	,	PUNCT
brj-24041	32	27	enhance	enhance	VERB
brj-24041	32	28	fatigue	fatigue	NOUN
brj-24041	32	29	,	,	PUNCT
brj-24041	32	30	promote	promote	VERB
brj-24041	32	31	mental	mental	ADJ
brj-24041	32	32	relaxation	relaxation	NOUN
brj-24041	32	33	,	,	PUNCT
brj-24041	32	34	facilitate	facilitate	VERB
brj-24041	32	35	the	the	DET
brj-24041	32	36	excretion	excretion	NOUN
brj-24041	32	37	of	of	ADP
brj-24041	32	38	feces	fece	NOUN
brj-24041	32	39	and	and	CCONJ
brj-24041	32	40	urine	urine	NOUN
brj-24041	32	41	,	,	PUNCT
brj-24041	32	42	and	and	CCONJ
brj-24041	32	43	suppress	suppress	ADJ
brj-24041	32	44	thirst	thirst	NOUN
brj-24041	32	45	(	(	PUNCT
brj-24041	32	46	park	park	NOUN
brj-24041	32	47	et	et	PROPN
brj-24041	32	48	al	al	PROPN
brj-24041	32	49	.	.	PROPN
brj-24041	32	50	2018	2018	NUM
brj-24041	32	51	)	)	PUNCT
brj-24041	32	52	.	.	PUNCT
brj-24041	33	1	the	the	DET
brj-24041	33	2	desiccated	desiccate	VERB
brj-24041	33	3	stem	stem	NOUN
brj-24041	33	4	of	of	ADP
brj-24041	33	5	the	the	DET
brj-24041	33	6	plant	plant	NOUN
brj-24041	33	7	most	most	ADV
brj-24041	33	8	commonly	commonly	ADV
brj-24041	33	9	serves	serve	VERB
brj-24041	33	10	as	as	ADP
brj-24041	33	11	a	a	DET
brj-24041	33	12	diuretic	diuretic	NOUN
brj-24041	33	13	for	for	ADP
brj-24041	33	14	the	the	DET
brj-24041	33	15	treatment	treatment	NOUN
brj-24041	33	16	of	of	ADP
brj-24041	33	17	hypothermia	hypothermia	NOUN
brj-24041	33	18	and	and	CCONJ
brj-24041	33	19	rheumatic	rheumatic	ADJ
brj-24041	33	20	pain	pain	NOUN
brj-24041	33	21	(	(	PUNCT
brj-24041	33	22	han	han	PROPN
brj-24041	33	23	et	et	PROPN
brj-24041	33	24	al	al	PROPN
brj-24041	33	25	.	.	PROPN
brj-24041	33	26	2012	2012	NUM
brj-24041	33	27	)	)	PUNCT
brj-24041	33	28	.	.	PUNCT
brj-24041	34	1	furthermore	furthermore	ADV
brj-24041	34	2	,	,	PUNCT
brj-24041	34	3	this	this	DET
brj-24041	34	4	plant	plant	NOUN
brj-24041	34	5	showed	show	VERB
brj-24041	34	6	antipyretic	antipyretic	ADJ
brj-24041	34	7	and	and	CCONJ
brj-24041	34	8	mild	mild	ADJ
brj-24041	34	9	analgesic	analgesic	ADJ
brj-24041	34	10	properties	property	NOUN
brj-24041	34	11	,	,	PUNCT
brj-24041	34	12	as	as	ADV
brj-24041	34	13	well	well	ADV
brj-24041	34	14	as	as	ADP
brj-24041	34	15	promoting	promote	VERB
brj-24041	34	16	intestinal	intestinal	ADJ
brj-24041	34	17	motility	motility	NOUN
brj-24041	34	18	and	and	CCONJ
brj-24041	34	19	control	control	NOUN
brj-24041	34	20	ileal	ileal	ADJ
brj-24041	34	21	contractility	contractility	NOUN
brj-24041	34	22	(	(	PUNCT
brj-24041	34	23	bensky	bensky	PROPN
brj-24041	34	24	et	et	PROPN
brj-24041	34	25	al	al	PROPN
brj-24041	34	26	.	.	PROPN
brj-24041	34	27	,	,	PUNCT
brj-24041	34	28	2004	2004	NUM
brj-24041	34	29	)	)	PUNCT
brj-24041	34	30	.	.	PUNCT
brj-24041	35	1	it	it	PRON
brj-24041	35	2	also	also	ADV
brj-24041	35	3	showed	show	VERB
brj-24041	35	4	protein	protein	NOUN
brj-24041	35	5	tyrosine	tyrosine	NOUN
brj-24041	35	6	phosphatase	phosphatase	NOUN
brj-24041	35	7	1b	1b	NUM
brj-24041	35	8	inhibitor	inhibitor	NOUN
brj-24041	35	9	activity	activity	NOUN
brj-24041	35	10	.	.	PUNCT
brj-24041	36	1	however	however	ADV
brj-24041	36	2	,	,	PUNCT
brj-24041	36	3	the	the	DET
brj-24041	36	4	impact	impact	NOUN
brj-24041	36	5	of	of	ADP
brj-24041	36	6	a.	a.	NOUN
brj-24041	36	7	quinata	quinata	PROPN
brj-24041	36	8	decaisne	decaisne	NOUN
brj-24041	36	9	aqueous	aqueous	ADJ
brj-24041	36	10	extract	extract	NOUN
brj-24041	36	11	(	(	PUNCT
brj-24041	36	12	aqde	aqde	ADV
brj-24041	36	13	)	)	PUNCT
brj-24041	36	14	on	on	ADP
brj-24041	36	15	osteoarthritis	osteoarthritis	NOUN
brj-24041	36	16	has	have	AUX
brj-24041	36	17	remained	remain	VERB
brj-24041	36	18	undetermined	undetermined	ADJ
brj-24041	36	19	.	.	PUNCT
brj-24041	37	1	the	the	DET
brj-24041	37	2	present	present	ADJ
brj-24041	37	3	study	study	NOUN
brj-24041	37	4	determined	determine	VERB
brj-24041	37	5	the	the	DET
brj-24041	37	6	pharmacological	pharmacological	ADJ
brj-24041	37	7	effect	effect	NOUN
brj-24041	37	8	and	and	CCONJ
brj-24041	37	9	mechanism	mechanism	NOUN
brj-24041	37	10	of	of	ADP
brj-24041	37	11	a.	a.	NOUN
brj-24041	37	12	quinate	quinate	NOUN
brj-24041	37	13	decaisne	decaisne	NOUN
brj-24041	37	14	(	(	PUNCT
brj-24041	37	15	aqde	aqde	NOUN
brj-24041	37	16	)	)	PUNCT
brj-24041	37	17	leaves	leave	VERB
brj-24041	37	18	aqueous	aqueous	ADJ
brj-24041	37	19	extract	extract	NOUN
brj-24041	37	20	in	in	ADP
brj-24041	37	21	osteoarthritis	osteoarthritis	NOUN
brj-24041	37	22	in	in	ADP
brj-24041	37	23	mouse	mouse	NOUN
brj-24041	37	24	chondrocytes	chondrocyte	NOUN
brj-24041	37	25	.	.	PUNCT
brj-24041	38	1	experimental	experimental	ADJ
brj-24041	38	2	preparation	preparation	NOUN
brj-24041	38	3	of	of	ADP
brj-24041	38	4	extract	extract	NOUN
brj-24041	38	5	a.	a.	NOUN
brj-24041	38	6	quinate	quinate	NOUN
brj-24041	38	7	decaisne	decaisne	NOUN
brj-24041	38	8	leaves	leave	NOUN
brj-24041	38	9	were	be	AUX
brj-24041	38	10	obtained	obtain	VERB
brj-24041	38	11	from	from	ADP
brj-24041	38	12	the	the	DET
brj-24041	38	13	commercial	commercial	ADJ
brj-24041	38	14	supplier	supplier	NOUN
brj-24041	38	15	and	and	CCONJ
brj-24041	38	16	authenticated	authenticate	VERB
brj-24041	38	17	by	by	ADP
brj-24041	38	18	an	an	DET
brj-24041	38	19	institutional	institutional	ADJ
brj-24041	38	20	botanist	botanist	NOUN
brj-24041	38	21	.	.	PUNCT
brj-24041	39	1	the	the	DET
brj-24041	39	2	midribs	midrib	NOUN
brj-24041	39	3	of	of	ADP
brj-24041	39	4	the	the	DET
brj-24041	39	5	several	several	ADJ
brj-24041	39	6	leaflets	leaflet	NOUN
brj-24041	39	7	(	(	PUNCT
brj-24041	39	8	usually	usually	ADV
brj-24041	39	9	five	five	NUM
brj-24041	39	10	to	to	PART
brj-24041	39	11	seven	seven	NUM
brj-24041	39	12	)	)	PUNCT
brj-24041	39	13	shoot	shoot	VERB
brj-24041	39	14	outward	outward	ADV
brj-24041	39	15	from	from	ADP
brj-24041	39	16	a	a	DET
brj-24041	39	17	single	single	ADJ
brj-24041	39	18	point	point	NOUN
brj-24041	39	19	on	on	ADP
brj-24041	39	20	the	the	DET
brj-24041	39	21	leaf	leaf	NOUN
brj-24041	39	22	.	.	PUNCT
brj-24041	40	1	the	the	DET
brj-24041	40	2	leaves	leave	NOUN
brj-24041	40	3	were	be	AUX
brj-24041	40	4	divided	divide	VERB
brj-24041	40	5	into	into	ADP
brj-24041	40	6	five	five	NUM
brj-24041	40	7	,	,	PUNCT
brj-24041	40	8	occasionally	occasionally	ADV
brj-24041	40	9	three	three	NUM
brj-24041	40	10	,	,	PUNCT
brj-24041	40	11	four	four	NUM
brj-24041	40	12	,	,	PUNCT
brj-24041	40	13	or	or	CCONJ
brj-24041	40	14	even	even	ADV
brj-24041	40	15	seven	seven	NUM
brj-24041	40	16	leaflets	leaflet	NOUN
brj-24041	40	17	,	,	PUNCT
brj-24041	40	18	and	and	CCONJ
brj-24041	40	19	they	they	PRON
brj-24041	40	20	were	be	AUX
brj-24041	40	21	observed	observe	VERB
brj-24041	40	22	to	to	PART
brj-24041	40	23	alternate	alternate	VERB
brj-24041	40	24	along	along	ADP
brj-24041	40	25	the	the	DET
brj-24041	40	26	stems	stem	NOUN
brj-24041	40	27	or	or	CCONJ
brj-24041	40	28	cluster	cluster	NOUN
brj-24041	40	29	on	on	ADP
brj-24041	40	30	the	the	DET
brj-24041	40	31	branchlets	branchlet	NOUN
brj-24041	40	32	.	.	PUNCT
brj-24041	41	1	the	the	DET
brj-24041	41	2	papery	papery	NOUN
brj-24041	41	3	leaves	leave	VERB
brj-24041	41	4	range	range	VERB
brj-24041	41	5	in	in	ADP
brj-24041	41	6	shape	shape	NOUN
brj-24041	41	7	from	from	ADP
brj-24041	41	8	oblong	oblong	ADJ
brj-24041	41	9	to	to	ADP
brj-24041	41	10	oblong	oblong	ADJ
brj-24041	41	11	-	-	PUNCT
brj-24041	41	12	elliptic	elliptic	ADJ
brj-24041	41	13	.	.	PUNCT
brj-24041	42	1	the	the	DET
brj-24041	42	2	leaflets	leaflet	NOUN
brj-24041	42	3	have	have	AUX
brj-24041	42	4	rounded	round	VERB
brj-24041	42	5	to	to	ADP
brj-24041	42	6	widely	widely	ADV
brj-24041	42	7	cuneate	cuneate	VERB
brj-24041	42	8	bases	basis	NOUN
brj-24041	42	9	and	and	CCONJ
brj-24041	42	10	are	be	AUX
brj-24041	42	11	adaxially	adaxially	ADV
brj-24041	42	12	dark	dark	ADJ
brj-24041	42	13	green	green	ADJ
brj-24041	42	14	(	(	PUNCT
brj-24041	42	15	dark	dark	ADJ
brj-24041	42	16	green	green	ADJ
brj-24041	42	17	above	above	ADV
brj-24041	42	18	)	)	PUNCT
brj-24041	42	19	and	and	CCONJ
brj-24041	42	20	abaxially	abaxially	ADV
brj-24041	42	21	glaucous	glaucous	ADJ
brj-24041	42	22	(	(	PUNCT
brj-24041	42	23	whitish	whitish	ADJ
brj-24041	42	24	below	below	ADP
brj-24041	42	25	)	)	PUNCT
brj-24041	42	26	.	.	PUNCT
brj-24041	43	1	the	the	DET
brj-24041	43	2	tip	tip	NOUN
brj-24041	43	3	that	that	PRON
brj-24041	43	4	is	be	AUX
brj-24041	43	5	farthest	farth	ADJ
brj-24041	43	6	from	from	ADP
brj-24041	43	7	the	the	DET
brj-24041	43	8	place	place	NOUN
brj-24041	43	9	of	of	ADP
brj-24041	43	10	attachment	attachment	NOUN
brj-24041	43	11	,	,	PUNCT
brj-24041	43	12	or	or	CCONJ
brj-24041	43	13	the	the	DET
brj-24041	43	14	apex	apex	NOUN
brj-24041	43	15	,	,	PUNCT
brj-24041	43	16	is	be	AUX
brj-24041	43	17	often	often	ADV
brj-24041	43	18	rounded	rounded	ADJ
brj-24041	43	19	and	and	CCONJ
brj-24041	43	20	either	either	CCONJ
brj-24041	43	21	cuspidate	cuspidate	VERB
brj-24041	43	22	(	(	PUNCT
brj-24041	43	23	with	with	ADP
brj-24041	43	24	a	a	DET
brj-24041	43	25	peer	peer	NOUN
brj-24041	43	26	-	-	PUNCT
brj-24041	43	27	reviewed	review	VERB
brj-24041	43	28	article	article	NOUN
brj-24041	43	29	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	43	30	wang	wang	PROPN
brj-24041	43	31	et	et	PROPN
brj-24041	43	32	al	al	PROPN
brj-24041	43	33	.	.	PROPN
brj-24041	44	1	(	(	PUNCT
brj-24041	44	2	2025	2025	NUM
brj-24041	44	3	)	)	PUNCT
brj-24041	44	4	.	.	PUNCT
brj-24041	45	1	“	"	PUNCT
brj-24041	45	2	leaf	leaf	NOUN
brj-24041	45	3	extract	extract	VERB
brj-24041	45	4	anti	anti	ADJ
brj-24041	45	5	-	-	ADJ
brj-24041	45	6	inflammation	inflammation	ADJ
brj-24041	45	7	,	,	PUNCT
brj-24041	45	8	”	"	PUNCT
brj-24041	45	9	bioresources	bioresource	NOUN
brj-24041	45	10	20(1	20(1	NUM
brj-24041	45	11	)	)	PUNCT
brj-24041	45	12	,	,	PUNCT
brj-24041	45	13	956	956	NUM
brj-24041	45	14	-	-	SYM
brj-24041	45	15	971	971	NUM
brj-24041	45	16	.	.	PUNCT
brj-24041	46	1	958	958	NUM
brj-24041	46	2	point	point	NOUN
brj-24041	46	3	)	)	PUNCT
brj-24041	46	4	or	or	CCONJ
brj-24041	46	5	emarginated	emarginate	VERB
brj-24041	46	6	(	(	PUNCT
brj-24041	46	7	notched	notch	VERB
brj-24041	46	8	)	)	PUNCT
brj-24041	46	9	.	.	PUNCT
brj-24041	47	1	the	the	DET
brj-24041	47	2	terminal	terminal	ADJ
brj-24041	47	3	leaflets	leaflet	NOUN
brj-24041	47	4	are	be	AUX
brj-24041	47	5	2.5	2.5	NUM
brj-24041	47	6	to	to	PART
brj-24041	47	7	5	5	NUM
brj-24041	47	8	(	(	PUNCT
brj-24041	47	9	or	or	CCONJ
brj-24041	47	10	to	to	ADP
brj-24041	47	11	7	7	NUM
brj-24041	47	12	)	)	PUNCT
brj-24041	47	13	cm	cm	NOUN
brj-24041	47	14	in	in	ADP
brj-24041	47	15	length	length	NOUN
brj-24041	47	16	,	,	PUNCT
brj-24041	47	17	while	while	SCONJ
brj-24041	47	18	the	the	DET
brj-24041	47	19	lateral	lateral	ADJ
brj-24041	47	20	leaflets	leaflet	NOUN
brj-24041	47	21	are	be	AUX
brj-24041	47	22	3	3	NUM
brj-24041	47	23	to	to	PART
brj-24041	47	24	5	5	NUM
brj-24041	47	25	x	x	SYM
brj-24041	47	26	1.5	1.5	NUM
brj-24041	47	27	to	to	ADP
brj-24041	47	28	2.5	2.5	NUM
brj-24041	47	29	cm	cm	NOUN
brj-24041	47	30	.	.	PUNCT
brj-24041	48	1	the	the	DET
brj-24041	48	2	sample	sample	NOUN
brj-24041	48	3	voucher	voucher	NOUN
brj-24041	48	4	(	(	PUNCT
brj-24041	48	5	no	no	INTJ
brj-24041	48	6	.	.	PUNCT
brj-24041	48	7	herb	herb	NOUN
brj-24041	48	8	/	/	SYM
brj-24041	48	9	sjtu/2024/34c2a	sjtu/2024/34c2a	CCONJ
brj-24041	48	10	)	)	PUNCT
brj-24041	48	11	was	be	AUX
brj-24041	48	12	deposited	deposit	VERB
brj-24041	48	13	in	in	ADP
brj-24041	48	14	the	the	DET
brj-24041	48	15	herbarium	herbarium	NOUN
brj-24041	48	16	of	of	ADP
brj-24041	48	17	the	the	DET
brj-24041	48	18	shanghai	shanghai	PROPN
brj-24041	48	19	jiao	jiao	PROPN
brj-24041	48	20	tong	tong	PROPN
brj-24041	48	21	university	university	PROPN
brj-24041	48	22	affiliated	affiliate	VERB
brj-24041	48	23	sixth	sixth	ADJ
brj-24041	48	24	people	people	NOUN
brj-24041	48	25	's	's	PART
brj-24041	48	26	hospital	hospital	NOUN
brj-24041	48	27	for	for	ADP
brj-24041	48	28	future	future	ADJ
brj-24041	48	29	reference	reference	NOUN
brj-24041	48	30	.	.	PUNCT
brj-24041	49	1	fresh	fresh	ADJ
brj-24041	49	2	or	or	CCONJ
brj-24041	49	3	mature	mature	ADJ
brj-24041	49	4	leaves	leave	NOUN
brj-24041	49	5	were	be	AUX
brj-24041	49	6	collected	collect	VERB
brj-24041	49	7	from	from	ADP
brj-24041	49	8	healthy	healthy	ADJ
brj-24041	49	9	plants	plant	NOUN
brj-24041	49	10	and	and	CCONJ
brj-24041	49	11	washed	wash	VERB
brj-24041	49	12	thoroughly	thoroughly	ADV
brj-24041	49	13	with	with	ADP
brj-24041	49	14	distilled	distil	VERB
brj-24041	49	15	water	water	NOUN
brj-24041	49	16	to	to	PART
brj-24041	49	17	remove	remove	VERB
brj-24041	49	18	dirt	dirt	NOUN
brj-24041	49	19	,	,	PUNCT
brj-24041	49	20	debris	debris	NOUN
brj-24041	49	21	,	,	PUNCT
brj-24041	49	22	and	and	CCONJ
brj-24041	49	23	contaminants	contaminant	NOUN
brj-24041	49	24	.	.	PUNCT
brj-24041	50	1	leaves	leave	NOUN
brj-24041	50	2	were	be	AUX
brj-24041	50	3	air	air	NOUN
brj-24041	50	4	-	-	PUNCT
brj-24041	50	5	dried	dry	VERB
brj-24041	50	6	in	in	ADP
brj-24041	50	7	a	a	DET
brj-24041	50	8	shaded	shaded	ADJ
brj-24041	50	9	,	,	PUNCT
brj-24041	50	10	well	well	ADV
brj-24041	50	11	-	-	PUNCT
brj-24041	50	12	ventilated	ventilate	VERB
brj-24041	50	13	area	area	NOUN
brj-24041	50	14	to	to	PART
brj-24041	50	15	prevent	prevent	VERB
brj-24041	50	16	degradation	degradation	NOUN
brj-24041	50	17	of	of	ADP
brj-24041	50	18	heat	heat	NOUN
brj-24041	50	19	-	-	PUNCT
brj-24041	50	20	sensitive	sensitive	ADJ
brj-24041	50	21	compounds	compound	NOUN
brj-24041	50	22	for	for	ADP
brj-24041	50	23	4	4	NUM
brj-24041	50	24	to	to	PART
brj-24041	50	25	5	5	NUM
brj-24041	50	26	days	day	NOUN
brj-24041	50	27	.	.	PUNCT
brj-24041	51	1	the	the	DET
brj-24041	51	2	extract	extract	NOUN
brj-24041	51	3	was	be	AUX
brj-24041	51	4	obtained	obtain	VERB
brj-24041	51	5	after	after	ADP
brj-24041	51	6	boiling	boil	VERB
brj-24041	51	7	the	the	DET
brj-24041	51	8	aqde	aqde	NOUN
brj-24041	51	9	in	in	ADP
brj-24041	51	10	water	water	NOUN
brj-24041	51	11	at	at	ADP
brj-24041	51	12	40	40	NUM
brj-24041	51	13	to	to	PART
brj-24041	51	14	60	60	NUM
brj-24041	51	15	°	°	NOUN
brj-24041	51	16	c	c	NOUN
brj-24041	51	17	for	for	ADP
brj-24041	51	18	6	6	NUM
brj-24041	51	19	to	to	PART
brj-24041	51	20	8	8	NUM
brj-24041	51	21	h	h	NOUN
brj-24041	51	22	and	and	CCONJ
brj-24041	51	23	filtered	filter	VERB
brj-24041	51	24	.	.	PUNCT
brj-24041	52	1	the	the	DET
brj-24041	52	2	filtrate	filtrate	NOUN
brj-24041	52	3	was	be	AUX
brj-24041	52	4	dried	dry	VERB
brj-24041	52	5	at	at	ADP
brj-24041	52	6	room	room	NOUN
brj-24041	52	7	temperature	temperature	NOUN
brj-24041	52	8	for	for	ADP
brj-24041	52	9	8	8	NUM
brj-24041	52	10	to	to	PART
brj-24041	52	11	12	12	NUM
brj-24041	52	12	days	day	NOUN
brj-24041	52	13	to	to	PART
brj-24041	52	14	obtain	obtain	VERB
brj-24041	52	15	dried	dried	ADJ
brj-24041	52	16	extract	extract	NOUN
brj-24041	52	17	powder	powder	NOUN
brj-24041	52	18	.	.	PUNCT
brj-24041	53	1	isolation	isolation	NOUN
brj-24041	53	2	of	of	ADP
brj-24041	53	3	mouse	mouse	NOUN
brj-24041	53	4	chondrocytes	chondrocyte	VERB
brj-24041	53	5	the	the	DET
brj-24041	53	6	primary	primary	ADJ
brj-24041	53	7	chondrocytes	chondrocyte	NOUN
brj-24041	53	8	were	be	AUX
brj-24041	53	9	extracted	extract	VERB
brj-24041	53	10	from	from	ADP
brj-24041	53	11	the	the	DET
brj-24041	53	12	bilateral	bilateral	ADJ
brj-24041	53	13	femoral	femoral	ADJ
brj-24041	53	14	head	head	NOUN
brj-24041	53	15	and	and	CCONJ
brj-24041	53	16	tibial	tibial	ADJ
brj-24041	53	17	plateau	plateau	NOUN
brj-24041	53	18	cartilage	cartilage	NOUN
brj-24041	53	19	of	of	ADP
brj-24041	53	20	14to	14to	ADJ
brj-24041	53	21	21	21	NUM
brj-24041	53	22	-	-	PUNCT
brj-24041	53	23	day	day	NOUN
brj-24041	53	24	-	-	PUNCT
brj-24041	53	25	old	old	ADJ
brj-24041	53	26	sd	sd	NOUN
brj-24041	53	27	rats	rat	NOUN
brj-24041	53	28	,	,	PUNCT
brj-24041	53	29	which	which	PRON
brj-24041	53	30	were	be	AUX
brj-24041	53	31	maintained	maintain	VERB
brj-24041	53	32	under	under	ADP
brj-24041	53	33	specified	specified	ADJ
brj-24041	53	34	pathogen	pathogen	NOUN
brj-24041	53	35	-	-	PUNCT
brj-24041	53	36	free	free	ADJ
brj-24041	53	37	conditions	condition	NOUN
brj-24041	53	38	as	as	ADP
brj-24041	53	39	per	per	ADP
brj-24041	53	40	the	the	DET
brj-24041	53	41	previously	previously	ADV
brj-24041	53	42	reported	report	VERB
brj-24041	53	43	procedure	procedure	NOUN
brj-24041	53	44	(	(	PUNCT
brj-24041	53	45	mirando	mirando	X
brj-24041	53	46	et	et	PROPN
brj-24041	53	47	al	al	PROPN
brj-24041	53	48	.	.	PROPN
brj-24041	53	49	2014	2014	NUM
brj-24041	53	50	;	;	PUNCT
brj-24041	53	51	jonason	jonason	PROPN
brj-24041	53	52	et	et	PROPN
brj-24041	53	53	al	al	PROPN
brj-24041	53	54	.	.	PROPN
brj-24041	53	55	2015	2015	NUM
brj-24041	53	56	)	)	PUNCT
brj-24041	53	57	.	.	PUNCT
brj-24041	54	1	before	before	ADP
brj-24041	54	2	being	be	AUX
brj-24041	54	3	digested	digest	VERB
brj-24041	54	4	with	with	ADP
brj-24041	54	5	0.25	0.25	NUM
brj-24041	54	6	%	%	NOUN
brj-24041	54	7	trypsin	trypsin	NOUN
brj-24041	54	8	,	,	PUNCT
brj-24041	54	9	the	the	DET
brj-24041	54	10	rat	rat	NOUN
brj-24041	54	11	articular	articular	ADJ
brj-24041	54	12	cartilage	cartilage	NOUN
brj-24041	54	13	was	be	AUX
brj-24041	54	14	sliced	slice	VERB
brj-24041	54	15	after	after	ADP
brj-24041	54	16	30	30	NUM
brj-24041	54	17	min	min	NOUN
brj-24041	54	18	,	,	PUNCT
brj-24041	54	19	and	and	CCONJ
brj-24041	54	20	then	then	ADV
brj-24041	54	21	digested	digest	VERB
brj-24041	54	22	for	for	ADP
brj-24041	54	23	4	4	NUM
brj-24041	54	24	hours	hour	NOUN
brj-24041	54	25	at	at	ADP
brj-24041	54	26	37	37	NUM
brj-24041	54	27	°	°	NOUN
brj-24041	54	28	c	c	NOUN
brj-24041	54	29	with	with	ADP
brj-24041	54	30	0.2	0.2	NUM
brj-24041	54	31	%	%	NOUN
brj-24041	54	32	collagenase	collagenase	NOUN
brj-24041	54	33	type	type	PROPN
brj-24041	54	34	ii	ii	PROPN
brj-24041	54	35	in	in	ADP
brj-24041	54	36	dmem	dmem	NOUN
brj-24041	54	37	-	-	PUNCT
brj-24041	54	38	f12	f12	NOUN
brj-24041	54	39	.	.	PUNCT
brj-24041	55	1	the	the	DET
brj-24041	55	2	chondrocyte	chondrocyte	PROPN
brj-24041	55	3	suspension	suspension	NOUN
brj-24041	55	4	was	be	AUX
brj-24041	55	5	centrifuged	centrifuge	VERB
brj-24041	55	6	at	at	ADP
brj-24041	55	7	1200	1200	NUM
brj-24041	55	8	rpm	rpm	NOUN
brj-24041	55	9	for	for	ADP
brj-24041	55	10	5	5	NUM
brj-24041	55	11	min	min	NOUN
brj-24041	55	12	.	.	PROPN
brj-24041	55	13	after	after	ADP
brj-24041	55	14	being	be	AUX
brj-24041	55	15	spun	spin	VERB
brj-24041	55	16	in	in	ADP
brj-24041	55	17	a	a	DET
brj-24041	55	18	centrifuge	centrifuge	NOUN
brj-24041	55	19	,	,	PUNCT
brj-24041	55	20	the	the	DET
brj-24041	55	21	settled	settle	VERB
brj-24041	55	22	chondrocytes	chondrocyte	NOUN
brj-24041	55	23	were	be	AUX
brj-24041	55	24	then	then	ADV
brj-24041	55	25	mixed	mix	VERB
brj-24041	55	26	again	again	ADV
brj-24041	55	27	with	with	ADP
brj-24041	55	28	10	10	NUM
brj-24041	55	29	%	%	NOUN
brj-24041	55	30	fbs	fb	NOUN
brj-24041	55	31	-	-	PUNCT
brj-24041	55	32	supplemented	supplement	VERB
brj-24041	55	33	dmem	dmem	ADJ
brj-24041	55	34	-	-	PUNCT
brj-24041	55	35	f12	f12	NOUN
brj-24041	55	36	complete	complete	ADJ
brj-24041	55	37	media	medium	NOUN
brj-24041	55	38	with	with	ADP
brj-24041	55	39	1	1	NUM
brj-24041	55	40	%	%	NOUN
brj-24041	55	41	streptomycin	streptomycin	PROPN
brj-24041	55	42	and	and	CCONJ
brj-24041	55	43	penicillin	penicillin	PROPN
brj-24041	55	44	.	.	PUNCT
brj-24041	56	1	chondrocytes	chondrocyte	NOUN
brj-24041	56	2	that	that	PRON
brj-24041	56	3	had	have	AUX
brj-24041	56	4	been	be	AUX
brj-24041	56	5	resuspended	resuspend	VERB
brj-24041	56	6	were	be	AUX
brj-24041	56	7	divided	divide	VERB
brj-24041	56	8	into	into	ADP
brj-24041	56	9	cultivated	cultivate	VERB
brj-24041	56	10	in	in	ADP
brj-24041	56	11	incubators	incubator	NOUN
brj-24041	56	12	with	with	ADP
brj-24041	56	13	5	5	NUM
brj-24041	56	14	%	%	NOUN
brj-24041	56	15	co2	co2	NOUN
brj-24041	56	16	at	at	ADP
brj-24041	56	17	37	37	NUM
brj-24041	56	18	°	°	NOUN
brj-24041	56	19	c	c	NOUN
brj-24041	56	20	in	in	ADP
brj-24041	56	21	cell	cell	NOUN
brj-24041	56	22	culture	culture	NOUN
brj-24041	56	23	flasks	flask	NOUN
brj-24041	56	24	manufactured	manufacture	VERB
brj-24041	56	25	by	by	ADP
brj-24041	56	26	corning	corn	VERB
brj-24041	56	27	(	(	PUNCT
brj-24041	56	28	new	new	PROPN
brj-24041	56	29	york	york	PROPN
brj-24041	56	30	,	,	PUNCT
brj-24041	56	31	usa	usa	PROPN
brj-24041	56	32	)	)	PUNCT
brj-24041	56	33	(	(	PUNCT
brj-24041	56	34	thermo	thermo	NOUN
brj-24041	56	35	fisher	fisher	PROPN
brj-24041	56	36	,	,	PUNCT
brj-24041	56	37	waltham	waltham	PROPN
brj-24041	56	38	,	,	PUNCT
brj-24041	56	39	ma	ma	PROPN
brj-24041	56	40	,	,	PUNCT
brj-24041	56	41	usa	usa	PROPN
brj-24041	56	42	)	)	PUNCT
brj-24041	56	43	.	.	PUNCT
brj-24041	57	1	to	to	PART
brj-24041	57	2	keep	keep	VERB
brj-24041	57	3	phenotypic	phenotypic	ADJ
brj-24041	57	4	loss	loss	NOUN
brj-24041	57	5	to	to	ADP
brj-24041	57	6	a	a	DET
brj-24041	57	7	minimum	minimum	NOUN
brj-24041	57	8	,	,	PUNCT
brj-24041	57	9	in	in	ADP
brj-24041	57	10	vitro	vitro	X
brj-24041	57	11	studies	study	NOUN
brj-24041	57	12	underwent	underwent	NOUN
brj-24041	57	13	procedures	procedure	NOUN
brj-24041	57	14	employing	employ	VERB
brj-24041	57	15	rat	rat	NOUN
brj-24041	57	16	chondrocytes	chondrocyte	NOUN
brj-24041	57	17	prior	prior	ADV
brj-24041	57	18	to	to	ADP
brj-24041	57	19	the	the	DET
brj-24041	57	20	second	second	ADJ
brj-24041	57	21	passage	passage	NOUN
brj-24041	57	22	.	.	PUNCT
brj-24041	58	1	effect	effect	NOUN
brj-24041	58	2	on	on	ADP
brj-24041	58	3	the	the	DET
brj-24041	58	4	cell	cell	NOUN
brj-24041	58	5	viability	viability	NOUN
brj-24041	58	6	the	the	DET
brj-24041	58	7	viability	viability	NOUN
brj-24041	58	8	of	of	ADP
brj-24041	58	9	the	the	DET
brj-24041	58	10	extract	extract	NOUN
brj-24041	58	11	was	be	AUX
brj-24041	58	12	investigated	investigate	VERB
brj-24041	58	13	on	on	ADP
brj-24041	58	14	the	the	DET
brj-24041	58	15	mouse	mouse	NOUN
brj-24041	58	16	chondrocytes	chondrocyte	NOUN
brj-24041	58	17	obtained	obtain	VERB
brj-24041	58	18	from	from	ADP
brj-24041	58	19	the	the	DET
brj-24041	58	20	mouse	mouse	NOUN
brj-24041	58	21	as	as	ADP
brj-24041	58	22	per	per	ADP
brj-24041	58	23	the	the	DET
brj-24041	58	24	previously	previously	ADV
brj-24041	58	25	reported	report	VERB
brj-24041	58	26	procedure	procedure	NOUN
brj-24041	58	27	.	.	PUNCT
brj-24041	59	1	the	the	DET
brj-24041	59	2	od	od	PROPN
brj-24041	59	3	value	value	NOUN
brj-24041	59	4	was	be	AUX
brj-24041	59	5	recorded	record	VERB
brj-24041	59	6	at	at	ADP
brj-24041	59	7	450	450	NUM
brj-24041	59	8	nm	nm	NOUN
brj-24041	59	9	using	use	VERB
brj-24041	59	10	the	the	DET
brj-24041	59	11	microplate	microplate	NOUN
brj-24041	59	12	reader	reader	NOUN
brj-24041	59	13	after	after	ADP
brj-24041	59	14	the	the	DET
brj-24041	59	15	complete	complete	ADJ
brj-24041	59	16	dissolution	dissolution	NOUN
brj-24041	59	17	of	of	ADP
brj-24041	59	18	formazan	formazan	ADJ
brj-24041	59	19	crystals	crystal	NOUN
brj-24041	59	20	(	(	PUNCT
brj-24041	59	21	srivastava	srivastava	PROPN
brj-24041	59	22	et	et	PROPN
brj-24041	59	23	al	al	PROPN
brj-24041	59	24	.	.	PROPN
brj-24041	59	25	2017	2017	NUM
brj-24041	59	26	)	)	PUNCT
brj-24041	59	27	.	.	PUNCT
brj-24041	60	1	qrt	qrt	ADJ
brj-24041	60	2	-	-	PUNCT
brj-24041	60	3	pcr	pcr	NOUN
brj-24041	60	4	analysis	analysis	NOUN
brj-24041	60	5	total	total	ADJ
brj-24041	60	6	rna	rna	NOUN
brj-24041	60	7	was	be	AUX
brj-24041	60	8	isolated	isolate	VERB
brj-24041	60	9	utilizing	utilize	VERB
brj-24041	60	10	an	an	DET
brj-24041	60	11	rna	rna	NOUN
brj-24041	60	12	extraction	extraction	NOUN
brj-24041	60	13	kit	kit	NOUN
brj-24041	60	14	(	(	PUNCT
brj-24041	60	15	tiangen	tiangen	NOUN
brj-24041	60	16	,	,	PUNCT
brj-24041	60	17	beijing	beijing	PROPN
brj-24041	60	18	,	,	PUNCT
brj-24041	60	19	china	china	PROPN
brj-24041	60	20	)	)	PUNCT
brj-24041	60	21	,	,	PUNCT
brj-24041	60	22	in	in	ADP
brj-24041	60	23	accordance	accordance	NOUN
brj-24041	60	24	with	with	ADP
brj-24041	60	25	the	the	DET
brj-24041	60	26	manufacturer	manufacturer	NOUN
brj-24041	60	27	’s	’s	PART
brj-24041	60	28	guidelines	guideline	NOUN
brj-24041	60	29	.	.	PUNCT
brj-24041	61	1	complementary	complementary	ADJ
brj-24041	61	2	dna	dna	PROPN
brj-24041	61	3	(	(	PUNCT
brj-24041	61	4	cdna	cdna	PROPN
brj-24041	61	5	)	)	PUNCT
brj-24041	61	6	was	be	AUX
brj-24041	61	7	generated	generate	VERB
brj-24041	61	8	using	use	VERB
brj-24041	61	9	reverse	reverse	ADJ
brj-24041	61	10	transcription	transcription	NOUN
brj-24041	61	11	utilizing	utilize	VERB
brj-24041	61	12	prime	prime	ADJ
brj-24041	61	13	script	script	NOUN
brj-24041	61	14	cdna	cdna	PROPN
brj-24041	61	15	rt	rt	PROPN
brj-24041	61	16	master	master	NOUN
brj-24041	61	17	mix	mix	NOUN
brj-24041	61	18	(	(	PUNCT
brj-24041	61	19	kogen	kogen	NOUN
brj-24041	61	20	,	,	PUNCT
brj-24041	61	21	tokyo	tokyo	PROPN
brj-24041	61	22	,	,	PUNCT
brj-24041	61	23	japan	japan	PROPN
brj-24041	61	24	)	)	PUNCT
brj-24041	61	25	.	.	PUNCT
brj-24041	62	1	amplification	amplification	NOUN
brj-24041	62	2	was	be	AUX
brj-24041	62	3	conducted	conduct	VERB
brj-24041	62	4	using	use	VERB
brj-24041	62	5	rnase	rnase	PROPN
brj-24041	62	6	ddh2o	ddh2o	PROPN
brj-24041	62	7	(	(	PUNCT
brj-24041	62	8	tiangen	tiangen	PROPN
brj-24041	62	9	,	,	PUNCT
brj-24041	62	10	beijing	beijing	PROPN
brj-24041	62	11	,	,	PUNCT
brj-24041	62	12	china	china	PROPN
brj-24041	62	13	)	)	PUNCT
brj-24041	62	14	,	,	PUNCT
brj-24041	62	15	sybr	sybr	PROPN
brj-24041	62	16	premix	premix	PROPN
brj-24041	62	17	ex	ex	NOUN
brj-24041	62	18	taq	taq	PROPN
brj-24041	62	19	™	™	PROPN
brj-24041	62	20	(	(	PUNCT
brj-24041	62	21	kogen	kogen	NOUN
brj-24041	62	22	,	,	PUNCT
brj-24041	62	23	tokyo	tokyo	PROPN
brj-24041	62	24	,	,	PUNCT
brj-24041	62	25	japan	japan	PROPN
brj-24041	62	26	)	)	PUNCT
brj-24041	62	27	,	,	PUNCT
brj-24041	62	28	along	along	ADP
brj-24041	62	29	with	with	ADP
brj-24041	62	30	forward	forward	ADV
brj-24041	62	31	and	and	CCONJ
brj-24041	62	32	reverse	reverse	VERB
brj-24041	62	33	primers	primer	NOUN
brj-24041	62	34	specific	specific	ADJ
brj-24041	62	35	to	to	ADP
brj-24041	62	36	the	the	DET
brj-24041	62	37	gene	gene	NOUN
brj-24041	62	38	of	of	ADP
brj-24041	62	39	interest	interest	NOUN
brj-24041	62	40	.	.	PUNCT
brj-24041	63	1	the	the	DET
brj-24041	63	2	complete	complete	ADJ
brj-24041	63	3	pcr	pcr	ADJ
brj-24041	63	4	procedure	procedure	NOUN
brj-24041	63	5	was	be	AUX
brj-24041	63	6	observed	observe	VERB
brj-24041	63	7	utilizing	utilize	VERB
brj-24041	63	8	a	a	DET
brj-24041	63	9	lightcycler	lightcycler	ADJ
brj-24041	63	10	®	®	NOUN
brj-24041	63	11	480	480	NUM
brj-24041	63	12	(	(	PUNCT
brj-24041	63	13	roche	roche	PROPN
brj-24041	63	14	,	,	PUNCT
brj-24041	63	15	germany	germany	PROPN
brj-24041	63	16	)	)	PUNCT
brj-24041	63	17	,	,	PUNCT
brj-24041	63	18	and	and	CCONJ
brj-24041	63	19	cycle	cycle	NOUN
brj-24041	63	20	threshold	threshold	NOUN
brj-24041	63	21	(	(	PUNCT
brj-24041	63	22	ct	ct	NOUN
brj-24041	63	23	)	)	PUNCT
brj-24041	63	24	relative	relative	ADJ
brj-24041	63	25	expression	expression	NOUN
brj-24041	63	26	levels	level	NOUN
brj-24041	63	27	were	be	AUX
brj-24041	63	28	determined	determine	VERB
brj-24041	63	29	employing	employ	VERB
brj-24041	63	30	the	the	DET
brj-24041	63	31	2	2	NUM
brj-24041	63	32	^	^	SYM
brj-24041	63	33	-ddct	-ddct	NOUN
brj-24041	63	34	technique	technique	NOUN
brj-24041	63	35	.	.	PUNCT
brj-24041	64	1	flow	flow	NOUN
brj-24041	64	2	cytometry	cytometry	NOUN
brj-24041	64	3	analysis	analysis	NOUN
brj-24041	64	4	a	a	DET
brj-24041	64	5	flow	flow	NOUN
brj-24041	64	6	cytometer	cytometer	NOUN
brj-24041	64	7	was	be	AUX
brj-24041	64	8	employed	employ	VERB
brj-24041	64	9	to	to	PART
brj-24041	64	10	assess	assess	VERB
brj-24041	64	11	the	the	DET
brj-24041	64	12	apoptosis	apoptosis	NOUN
brj-24041	64	13	in	in	ADP
brj-24041	64	14	the	the	DET
brj-24041	64	15	examined	examine	VERB
brj-24041	64	16	cells	cell	NOUN
brj-24041	64	17	(	(	PUNCT
brj-24041	64	18	10,000	10,000	NUM
brj-24041	64	19	events	event	NOUN
brj-24041	64	20	recorded	record	VERB
brj-24041	64	21	)	)	PUNCT
brj-24041	64	22	.	.	PUNCT
brj-24041	65	1	annexin	annexin	PROPN
brj-24041	65	2	v	v	PROPN
brj-24041	65	3	had	have	VERB
brj-24041	65	4	a	a	DET
brj-24041	65	5	strong	strong	ADJ
brj-24041	65	6	affinity	affinity	NOUN
brj-24041	65	7	for	for	ADP
brj-24041	65	8	phosphatidylserine	phosphatidylserine	NOUN
brj-24041	65	9	,	,	PUNCT
brj-24041	65	10	enabling	enable	VERB
brj-24041	65	11	the	the	DET
brj-24041	65	12	detection	detection	NOUN
brj-24041	65	13	of	of	ADP
brj-24041	65	14	cells	cell	NOUN
brj-24041	65	15	at	at	ADP
brj-24041	65	16	all	all	DET
brj-24041	65	17	phases	phase	NOUN
brj-24041	65	18	of	of	ADP
brj-24041	65	19	apoptosis	apoptosis	NOUN
brj-24041	65	20	using	use	VERB
brj-24041	65	21	this	this	DET
brj-24041	65	22	protein	protein	NOUN
brj-24041	65	23	.	.	PUNCT
brj-24041	66	1	propidine	propidine	PROPN
brj-24041	66	2	iodide	iodide	NOUN
brj-24041	66	3	(	(	PUNCT
brj-24041	66	4	pi	pi	NOUN
brj-24041	66	5	)	)	PUNCT
brj-24041	66	6	was	be	AUX
brj-24041	66	7	employed	employ	VERB
brj-24041	66	8	to	to	PART
brj-24041	66	9	detect	detect	VERB
brj-24041	66	10	late	late	ADJ
brj-24041	66	11	-	-	PUNCT
brj-24041	66	12	apoptotic	apoptotic	ADJ
brj-24041	66	13	and	and	CCONJ
brj-24041	66	14	necrotic	necrotic	ADJ
brj-24041	66	15	cells	cell	NOUN
brj-24041	66	16	due	due	ADP
brj-24041	66	17	to	to	ADP
brj-24041	66	18	its	its	PRON
brj-24041	66	19	ability	ability	NOUN
brj-24041	66	20	to	to	PART
brj-24041	66	21	stain	stain	VERB
brj-24041	66	22	cells	cell	NOUN
brj-24041	66	23	with	with	ADP
brj-24041	66	24	compromised	compromise	VERB
brj-24041	66	25	cell	cell	NOUN
brj-24041	66	26	membranes	membrane	NOUN
brj-24041	66	27	.	.	PUNCT
brj-24041	67	1	the	the	DET
brj-24041	67	2	control	control	NOUN
brj-24041	67	3	consisted	consist	VERB
brj-24041	67	4	of	of	ADP
brj-24041	67	5	cells	cell	NOUN
brj-24041	67	6	cultivated	cultivate	VERB
brj-24041	67	7	in	in	ADP
brj-24041	67	8	a	a	DET
brj-24041	67	9	drug	drug	NOUN
brj-24041	67	10	-	-	PUNCT
brj-24041	67	11	free	free	ADJ
brj-24041	67	12	medium	medium	NOUN
brj-24041	67	13	.	.	PUNCT
brj-24041	68	1	a	a	DET
brj-24041	68	2	positive	positive	ADJ
brj-24041	68	3	control	control	NOUN
brj-24041	68	4	(	(	PUNCT
brj-24041	68	5	cells	cell	NOUN
brj-24041	68	6	treated	treat	VERB
brj-24041	68	7	with	with	ADP
brj-24041	68	8	3	3	NUM
brj-24041	68	9	%	%	NOUN
brj-24041	68	10	formaldehyde	formaldehyde	NOUN
brj-24041	68	11	in	in	ADP
brj-24041	68	12	buffer	buffer	NOUN
brj-24041	68	13	for	for	ADP
brj-24041	68	14	30	30	NUM
brj-24041	68	15	min	min	NOUN
brj-24041	68	16	on	on	ADP
brj-24041	68	17	ice	ice	NOUN
brj-24041	68	18	)	)	PUNCT
brj-24041	68	19	was	be	AUX
brj-24041	68	20	employed	employ	VERB
brj-24041	68	21	to	to	PART
brj-24041	68	22	determine	determine	VERB
brj-24041	68	23	the	the	DET
brj-24041	68	24	optimal	optimal	ADJ
brj-24041	68	25	parameter	parameter	NOUN
brj-24041	68	26	settings	setting	NOUN
brj-24041	68	27	.	.	PUNCT
brj-24041	69	1	an	an	DET
brj-24041	69	2	analysis	analysis	NOUN
brj-24041	69	3	of	of	ADP
brj-24041	69	4	the	the	DET
brj-24041	69	5	findings	finding	NOUN
brj-24041	69	6	peer	peer	NOUN
brj-24041	69	7	-	-	PUNCT
brj-24041	69	8	reviewed	review	VERB
brj-24041	69	9	article	article	NOUN
brj-24041	69	10	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	69	11	wang	wang	PROPN
brj-24041	69	12	et	et	PROPN
brj-24041	69	13	al	al	PROPN
brj-24041	69	14	.	.	PROPN
brj-24041	70	1	(	(	PUNCT
brj-24041	70	2	2025	2025	NUM
brj-24041	70	3	)	)	PUNCT
brj-24041	70	4	.	.	PUNCT
brj-24041	71	1	“	"	PUNCT
brj-24041	71	2	leaf	leaf	NOUN
brj-24041	71	3	extract	extract	VERB
brj-24041	71	4	anti	anti	ADJ
brj-24041	71	5	-	-	ADJ
brj-24041	71	6	inflammation	inflammation	ADJ
brj-24041	71	7	,	,	PUNCT
brj-24041	71	8	”	"	PUNCT
brj-24041	71	9	bioresources	bioresource	NOUN
brj-24041	71	10	20(1	20(1	NUM
brj-24041	71	11	)	)	PUNCT
brj-24041	71	12	,	,	PUNCT
brj-24041	71	13	956	956	NUM
brj-24041	71	14	-	-	SYM
brj-24041	71	15	971	971	NUM
brj-24041	71	16	.	.	PUNCT
brj-24041	72	1	959	959	NUM
brj-24041	72	2	was	be	AUX
brj-24041	72	3	conducted	conduct	VERB
brj-24041	72	4	with	with	ADP
brj-24041	72	5	facsdiva	facsdiva	NOUN
brj-24041	72	6	software	software	NOUN
brj-24041	72	7	.	.	PUNCT
brj-24041	73	1	animals	animal	NOUN
brj-24041	73	2	female	female	ADJ
brj-24041	73	3	sprague	sprague	NOUN
brj-24041	73	4	-	-	PUNCT
brj-24041	73	5	dawley	dawley	NOUN
brj-24041	73	6	rats	rat	NOUN
brj-24041	73	7	,	,	PUNCT
brj-24041	73	8	aged	aged	ADJ
brj-24041	73	9	6	6	NUM
brj-24041	73	10	weeks	week	NOUN
brj-24041	73	11	,	,	PUNCT
brj-24041	73	12	were	be	AUX
brj-24041	73	13	procured	procure	VERB
brj-24041	73	14	from	from	ADP
brj-24041	73	15	a	a	DET
brj-24041	73	16	commercial	commercial	ADJ
brj-24041	73	17	supplier	supplier	NOUN
brj-24041	73	18	and	and	CCONJ
brj-24041	73	19	provided	provide	VERB
brj-24041	73	20	with	with	ADP
brj-24041	73	21	standard	standard	ADJ
brj-24041	73	22	chow	chow	PROPN
brj-24041	73	23	and	and	CCONJ
brj-24041	73	24	unrestricted	unrestricted	ADJ
brj-24041	73	25	access	access	NOUN
brj-24041	73	26	to	to	ADP
brj-24041	73	27	water	water	NOUN
brj-24041	73	28	.	.	PUNCT
brj-24041	74	1	the	the	DET
brj-24041	74	2	study	study	NOUN
brj-24041	74	3	adheres	adhere	VERB
brj-24041	74	4	to	to	ADP
brj-24041	74	5	the	the	DET
brj-24041	74	6	guide	guide	NOUN
brj-24041	74	7	for	for	ADP
brj-24041	74	8	care	care	NOUN
brj-24041	74	9	and	and	CCONJ
brj-24041	74	10	use	use	NOUN
brj-24041	74	11	of	of	ADP
brj-24041	74	12	laboratory	laboratory	NOUN
brj-24041	74	13	animals	animal	NOUN
brj-24041	74	14	published	publish	VERB
brj-24041	74	15	by	by	ADP
brj-24041	74	16	the	the	DET
brj-24041	74	17	us	us	PROPN
brj-24041	74	18	national	national	PROPN
brj-24041	74	19	institutes	institutes	PROPN
brj-24041	74	20	of	of	ADP
brj-24041	74	21	health	health	PROPN
brj-24041	74	22	(	(	PUNCT
brj-24041	74	23	nih	nih	PROPN
brj-24041	74	24	publication	publication	PROPN
brj-24041	74	25	no	no	PROPN
brj-24041	74	26	.	.	PROPN
brj-24041	74	27	85	85	NUM
brj-24041	74	28	-	-	SYM
brj-24041	74	29	23	23	NUM
brj-24041	74	30	,	,	PUNCT
brj-24041	74	31	revised	revise	VERB
brj-24041	74	32	2011	2011	NUM
brj-24041	74	33	)	)	PUNCT
brj-24041	74	34	and	and	CCONJ
brj-24041	74	35	was	be	AUX
brj-24041	74	36	approved	approve	VERB
brj-24041	74	37	by	by	ADP
brj-24041	74	38	the	the	DET
brj-24041	74	39	ethics	ethic	NOUN
brj-24041	74	40	committee	committee	PROPN
brj-24041	74	41	for	for	ADP
brj-24041	74	42	animal	animal	NOUN
brj-24041	74	43	experimentation	experimentation	NOUN
brj-24041	74	44	at	at	ADP
brj-24041	74	45	the	the	DET
brj-24041	74	46	shanghai	shanghai	PROPN
brj-24041	74	47	jiao	jiao	PROPN
brj-24041	74	48	tong	tong	PROPN
brj-24041	74	49	university	university	PROPN
brj-24041	74	50	affiliated	affiliate	VERB
brj-24041	74	51	sixth	sixth	ADJ
brj-24041	74	52	people	people	NOUN
brj-24041	74	53	’s	’s	PART
brj-24041	74	54	hospital	hospital	NOUN
brj-24041	74	55	,	,	PUNCT
brj-24041	74	56	china	china	PROPN
brj-24041	74	57	(	(	PUNCT
brj-24041	74	58	approval	approval	NOUN
brj-24041	74	59	no	no	PRON
brj-24041	74	60	:	:	PUNCT
brj-24041	74	61	ae/2024	ae/2024	NOUN
brj-24041	74	62	/	/	SYM
brj-24041	74	63	c-34/21	c-34/21	NOUN
brj-24041	74	64	)	)	PUNCT
brj-24041	74	65	.	.	PUNCT
brj-24041	75	1	monosodium	monosodium	NOUN
brj-24041	75	2	iodoacetate	iodoacetate	NOUN
brj-24041	75	3	induced	induce	VERB
brj-24041	75	4	oa	oa	PROPN
brj-24041	75	5	model	model	NOUN
brj-24041	75	6	unilateral	unilateral	ADJ
brj-24041	75	7	knee	knee	NOUN
brj-24041	75	8	osteoarthritis	osteoarthritis	NOUN
brj-24041	75	9	was	be	AUX
brj-24041	75	10	generated	generate	VERB
brj-24041	75	11	by	by	ADP
brj-24041	75	12	a	a	DET
brj-24041	75	13	single	single	ADJ
brj-24041	75	14	intra	intra	ADJ
brj-24041	75	15	-	-	ADJ
brj-24041	75	16	articular	articular	ADJ
brj-24041	75	17	injection	injection	NOUN
brj-24041	75	18	of	of	ADP
brj-24041	75	19	monosodium	monosodium	NOUN
brj-24041	75	20	iodoacetate	iodoacetate	NOUN
brj-24041	75	21	(	(	PUNCT
brj-24041	75	22	mia	mia	NOUN
brj-24041	75	23	)	)	PUNCT
brj-24041	75	24	in	in	ADP
brj-24041	75	25	the	the	DET
brj-24041	75	26	infrapatellar	infrapatellar	ADJ
brj-24041	75	27	region	region	NOUN
brj-24041	75	28	of	of	ADP
brj-24041	75	29	the	the	DET
brj-24041	75	30	right	right	ADJ
brj-24041	75	31	knee	knee	NOUN
brj-24041	75	32	of	of	ADP
brj-24041	75	33	male	male	PROPN
brj-24041	75	34	wistar	wistar	PROPN
brj-24041	75	35	rats	rat	NOUN
brj-24041	75	36	as	as	ADP
brj-24041	75	37	per	per	ADP
brj-24041	75	38	the	the	DET
brj-24041	75	39	previously	previously	ADV
brj-24041	75	40	reported	report	VERB
brj-24041	75	41	procedure	procedure	NOUN
brj-24041	75	42	(	(	PUNCT
brj-24041	75	43	lee	lee	PROPN
brj-24041	75	44	et	et	PROPN
brj-24041	75	45	al	al	PROPN
brj-24041	75	46	.	.	PROPN
brj-24041	75	47	2022a	2022a	NUM
brj-24041	75	48	;	;	PUNCT
brj-24041	75	49	park	park	NOUN
brj-24041	75	50	et	et	PROPN
brj-24041	75	51	al	al	PROPN
brj-24041	75	52	.	.	PROPN
brj-24041	75	53	2017	2017	NUM
brj-24041	75	54	)	)	PUNCT
brj-24041	75	55	.	.	PUNCT
brj-24041	76	1	a	a	DET
brj-24041	76	2	total	total	NOUN
brj-24041	76	3	of	of	ADP
brj-24041	76	4	30	30	NUM
brj-24041	76	5	animals	animal	NOUN
brj-24041	76	6	were	be	AUX
brj-24041	76	7	utilized	utilize	VERB
brj-24041	76	8	,	,	PUNCT
brj-24041	76	9	comprising	comprise	VERB
brj-24041	76	10	six	six	NUM
brj-24041	76	11	rats	rat	NOUN
brj-24041	76	12	each	each	DET
brj-24041	76	13	group	group	NOUN
brj-24041	76	14	.	.	PUNCT
brj-24041	77	1	on	on	ADP
brj-24041	77	2	the	the	DET
brj-24041	77	3	first	first	ADJ
brj-24041	77	4	day	day	NOUN
brj-24041	77	5	,	,	PUNCT
brj-24041	77	6	rats	rat	NOUN
brj-24041	77	7	were	be	AUX
brj-24041	77	8	sedated	sedate	VERB
brj-24041	77	9	with	with	ADP
brj-24041	77	10	2	2	NUM
brj-24041	77	11	%	%	NOUN
brj-24041	77	12	isoflurane	isoflurane	NOUN
brj-24041	77	13	in	in	ADP
brj-24041	77	14	pure	pure	ADJ
brj-24041	77	15	oxygen	oxygen	NOUN
brj-24041	77	16	.	.	PUNCT
brj-24041	78	1	the	the	DET
brj-24041	78	2	skin	skin	NOUN
brj-24041	78	3	of	of	ADP
brj-24041	78	4	the	the	DET
brj-24041	78	5	right	right	ADJ
brj-24041	78	6	leg	leg	NOUN
brj-24041	78	7	was	be	AUX
brj-24041	78	8	disinfected	disinfect	VERB
brj-24041	78	9	with	with	ADP
brj-24041	78	10	75	75	NUM
brj-24041	78	11	%	%	NOUN
brj-24041	78	12	ethyl	ethyl	PROPN
brj-24041	78	13	alcohol	alcohol	PROPN
brj-24041	78	14	,	,	PUNCT
brj-24041	78	15	and	and	CCONJ
brj-24041	78	16	the	the	DET
brj-24041	78	17	knee	knee	NOUN
brj-24041	78	18	was	be	AUX
brj-24041	78	19	identified	identify	VERB
brj-24041	78	20	through	through	ADP
brj-24041	78	21	palpation	palpation	NOUN
brj-24041	78	22	.	.	PUNCT
brj-24041	79	1	a	a	DET
brj-24041	79	2	26	26	NUM
brj-24041	79	3	-	-	PUNCT
brj-24041	79	4	gauge	gauge	NOUN
brj-24041	79	5	needle	needle	NOUN
brj-24041	79	6	was	be	AUX
brj-24041	79	7	placed	place	VERB
brj-24041	79	8	vertically	vertically	ADV
brj-24041	79	9	to	to	PART
brj-24041	79	10	breach	breach	VERB
brj-24041	79	11	the	the	DET
brj-24041	79	12	epidermis	epidermis	NOUN
brj-24041	79	13	and	and	CCONJ
brj-24041	79	14	then	then	ADV
brj-24041	79	15	rotated	rotate	VERB
brj-24041	79	16	distally	distally	ADV
brj-24041	79	17	for	for	ADP
brj-24041	79	18	entry	entry	NOUN
brj-24041	79	19	into	into	ADP
brj-24041	79	20	the	the	DET
brj-24041	79	21	articular	articular	ADJ
brj-24041	79	22	cavity	cavity	NOUN
brj-24041	79	23	,	,	PUNCT
brj-24041	79	24	until	until	SCONJ
brj-24041	79	25	a	a	DET
brj-24041	79	26	notable	notable	ADJ
brj-24041	79	27	reduction	reduction	NOUN
brj-24041	79	28	of	of	ADP
brj-24041	79	29	resistance	resistance	NOUN
brj-24041	79	30	was	be	AUX
brj-24041	79	31	observed	observe	VERB
brj-24041	79	32	;	;	PUNCT
brj-24041	79	33	thereafter	thereafter	ADV
brj-24041	79	34	,	,	PUNCT
brj-24041	79	35	1	1	NUM
brj-24041	79	36	mg	mg	ADP
brj-24041	79	37	of	of	ADP
brj-24041	79	38	mia	mia	PROPN
brj-24041	79	39	in	in	ADP
brj-24041	79	40	50	50	NUM
brj-24041	79	41	μl	μl	DET
brj-24041	79	42	saline	saline	NOUN
brj-24041	79	43	was	be	AUX
brj-24041	79	44	administered	administer	VERB
brj-24041	79	45	into	into	ADP
brj-24041	79	46	the	the	DET
brj-24041	79	47	articular	articular	ADJ
brj-24041	79	48	cavity	cavity	NOUN
brj-24041	79	49	.	.	PUNCT
brj-24041	80	1	the	the	DET
brj-24041	80	2	control	control	NOUN
brj-24041	80	3	rats	rat	NOUN
brj-24041	80	4	(	(	PUNCT
brj-24041	80	5	sham	sham	PROPN
brj-24041	80	6	)	)	PUNCT
brj-24041	80	7	were	be	AUX
brj-24041	80	8	administered	administer	VERB
brj-24041	80	9	50	50	NUM
brj-24041	80	10	μl	μl	ADP
brj-24041	80	11	of	of	ADP
brj-24041	80	12	saline	saline	ADJ
brj-24041	80	13	solution	solution	NOUN
brj-24041	80	14	.	.	PUNCT
brj-24041	81	1	all	all	DET
brj-24041	81	2	animals	animal	NOUN
brj-24041	81	3	were	be	AUX
brj-24041	81	4	euthanized	euthanize	VERB
brj-24041	81	5	21	21	NUM
brj-24041	81	6	days	day	NOUN
brj-24041	81	7	following	follow	VERB
brj-24041	81	8	the	the	DET
brj-24041	81	9	intra	intra	ADJ
brj-24041	81	10	-	-	ADJ
brj-24041	81	11	articular	articular	ADJ
brj-24041	81	12	administration	administration	NOUN
brj-24041	81	13	of	of	ADP
brj-24041	81	14	either	either	CCONJ
brj-24041	81	15	mia	mia	PROPN
brj-24041	81	16	or	or	CCONJ
brj-24041	81	17	saline	saline	ADJ
brj-24041	81	18	solution	solution	NOUN
brj-24041	81	19	.	.	PUNCT
brj-24041	82	1	von	von	PROPN
brj-24041	82	2	frey	frey	PROPN
brj-24041	82	3	test	test	NOUN
brj-24041	82	4	the	the	DET
brj-24041	82	5	rats	rat	NOUN
brj-24041	82	6	were	be	AUX
brj-24041	82	7	subjected	subject	VERB
brj-24041	82	8	to	to	ADP
brj-24041	82	9	testing	test	VERB
brj-24041	82	10	every	every	DET
brj-24041	82	11	day	day	NOUN
brj-24041	82	12	after	after	ADP
brj-24041	82	13	an	an	DET
brj-24041	82	14	acclimation	acclimation	NOUN
brj-24041	82	15	period	period	NOUN
brj-24041	82	16	of	of	ADP
brj-24041	82	17	one	one	NUM
brj-24041	82	18	hour	hour	NOUN
brj-24041	82	19	in	in	ADP
brj-24041	82	20	a	a	DET
brj-24041	82	21	plexiglas	plexiglas	PROPN
brj-24041	82	22	chamber	chamber	NOUN
brj-24041	82	23	of	of	ADP
brj-24041	82	24	28×40×35	28×40×35	NUM
brj-24041	82	25	cm	cm	NOUN
brj-24041	82	26	with	with	ADP
brj-24041	82	27	a	a	DET
brj-24041	82	28	wire	wire	NOUN
brj-24041	82	29	mesh	mesh	NOUN
brj-24041	82	30	bottom	bottom	NOUN
brj-24041	82	31	,	,	PUNCT
brj-24041	82	32	situated	situate	VERB
brj-24041	82	33	20	20	NUM
brj-24041	82	34	cm	cm	NOUN
brj-24041	82	35	above	above	ADP
brj-24041	82	36	the	the	DET
brj-24041	82	37	bench	bench	NOUN
brj-24041	82	38	as	as	ADP
brj-24041	82	39	per	per	ADP
brj-24041	82	40	the	the	DET
brj-24041	82	41	previously	previously	ADV
brj-24041	82	42	reported	report	VERB
brj-24041	82	43	procedure	procedure	NOUN
brj-24041	82	44	(	(	PUNCT
brj-24041	82	45	de	de	X
brj-24041	82	46	morais	morais	PROPN
brj-24041	82	47	et	et	PROPN
brj-24041	82	48	al	al	PROPN
brj-24041	82	49	.	.	PROPN
brj-24041	82	50	2016	2016	NUM
brj-24041	82	51	;	;	PUNCT
brj-24041	82	52	fusco	fusco	PROPN
brj-24041	82	53	et	et	PROPN
brj-24041	82	54	al	al	PROPN
brj-24041	82	55	.	.	PROPN
brj-24041	82	56	2020	2020	NUM
brj-24041	82	57	)	)	PUNCT
brj-24041	82	58	.	.	PUNCT
brj-24041	83	1	following	follow	VERB
brj-24041	83	2	the	the	DET
brj-24041	83	3	initial	initial	ADJ
brj-24041	83	4	adaptation	adaptation	NOUN
brj-24041	83	5	phase	phase	NOUN
brj-24041	83	6	,	,	PUNCT
brj-24041	83	7	a	a	DET
brj-24041	83	8	servo	servo	NOUN
brj-24041	83	9	-	-	PUNCT
brj-24041	83	10	controlled	control	VERB
brj-24041	83	11	mechanical	mechanical	ADJ
brj-24041	83	12	stimulus	stimulus	NOUN
brj-24041	83	13	—	—	PUNCT
brj-24041	83	14	a	a	DET
brj-24041	83	15	pointed	pointed	ADJ
brj-24041	83	16	metallic	metallic	ADJ
brj-24041	83	17	filament	filament	NOUN
brj-24041	83	18	with	with	ADP
brj-24041	83	19	a	a	DET
brj-24041	83	20	diameter	diameter	NOUN
brj-24041	83	21	of	of	ADP
brj-24041	83	22	0.5	0.5	NUM
brj-24041	83	23	mm	mm	NOUN
brj-24041	83	24	—	—	PUNCT
brj-24041	83	25	was	be	AUX
brj-24041	83	26	placed	place	VERB
brj-24041	83	27	under	under	ADP
brj-24041	83	28	the	the	DET
brj-24041	83	29	back	back	NOUN
brj-24041	83	30	paw	paw	PROPN
brj-24041	83	31	’s	’s	PART
brj-24041	83	32	plantar	plantar	NOUN
brj-24041	83	33	surface	surface	NOUN
brj-24041	83	34	.	.	PUNCT
brj-24041	84	1	this	this	DET
brj-24041	84	2	stimulus	stimulus	NOUN
brj-24041	84	3	applied	apply	VERB
brj-24041	84	4	a	a	DET
brj-24041	84	5	periodic	periodic	ADJ
brj-24041	84	6	pressure	pressure	NOUN
brj-24041	84	7	that	that	PRON
brj-24041	84	8	increased	increase	VERB
brj-24041	84	9	linearly	linearly	ADV
brj-24041	84	10	over	over	ADP
brj-24041	84	11	20	20	NUM
brj-24041	84	12	seconds	second	NOUN
brj-24041	84	13	,	,	PUNCT
brj-24041	84	14	eventually	eventually	ADV
brj-24041	84	15	reaching	reach	VERB
brj-24041	84	16	50	50	NUM
brj-24041	84	17	g.	g.	NOUN
brj-24041	84	18	the	the	DET
brj-24041	84	19	automatic	automatic	ADJ
brj-24041	84	20	recording	recording	NOUN
brj-24041	84	21	of	of	ADP
brj-24041	84	22	a	a	DET
brj-24041	84	23	distinct	distinct	ADJ
brj-24041	84	24	and	and	CCONJ
brj-24041	84	25	unprompted	unprompted	ADJ
brj-24041	84	26	withdrawal	withdrawal	NOUN
brj-24041	84	27	of	of	ADP
brj-24041	84	28	the	the	DET
brj-24041	84	29	hind	hind	NOUN
brj-24041	84	30	paw	paw	NOUN
brj-24041	84	31	in	in	ADP
brj-24041	84	32	response	response	NOUN
brj-24041	84	33	to	to	PART
brj-24041	84	34	punctuate	punctuate	VERB
brj-24041	84	35	pressure	pressure	NOUN
brj-24041	84	36	was	be	AUX
brj-24041	84	37	made	make	VERB
brj-24041	84	38	.	.	PUNCT
brj-24041	85	1	the	the	DET
brj-24041	85	2	findings	finding	NOUN
brj-24041	85	3	determined	determine	VERB
brj-24041	85	4	the	the	DET
brj-24041	85	5	gram	gram	NOUN
brj-24041	85	6	-	-	PUNCT
brj-24041	85	7	level	level	NOUN
brj-24041	85	8	pressure	pressure	NOUN
brj-24041	85	9	necessary	necessary	ADJ
brj-24041	85	10	to	to	PART
brj-24041	85	11	trigger	trigger	VERB
brj-24041	85	12	a	a	DET
brj-24041	85	13	strong	strong	ADJ
brj-24041	85	14	and	and	CCONJ
brj-24041	85	15	rapid	rapid	ADJ
brj-24041	85	16	paw	paw	NOUN
brj-24041	85	17	withdrawal	withdrawal	NOUN
brj-24041	85	18	reaction	reaction	NOUN
brj-24041	85	19	.	.	PUNCT
brj-24041	86	1	to	to	PART
brj-24041	86	2	find	find	VERB
brj-24041	86	3	the	the	DET
brj-24041	86	4	mechanical	mechanical	ADJ
brj-24041	86	5	allodynic	allodynic	ADJ
brj-24041	86	6	threshold	threshold	NOUN
brj-24041	86	7	,	,	PUNCT
brj-24041	86	8	stimuli	stimulus	NOUN
brj-24041	86	9	were	be	AUX
brj-24041	86	10	administered	administer	VERB
brj-24041	86	11	alternately	alternately	ADV
brj-24041	86	12	to	to	ADP
brj-24041	86	13	the	the	DET
brj-24041	86	14	hind	hind	NOUN
brj-24041	86	15	paws	paw	NOUN
brj-24041	86	16	every	every	DET
brj-24041	86	17	two	two	NUM
brj-24041	86	18	min	min	NOUN
brj-24041	86	19	for	for	ADP
brj-24041	86	20	three	three	NUM
brj-24041	86	21	separate	separate	ADJ
brj-24041	86	22	measurements	measurement	NOUN
brj-24041	86	23	.	.	PUNCT
brj-24041	87	1	knee	knee	NOUN
brj-24041	87	2	joint	joint	ADJ
brj-24041	87	3	thickness	thickness	NOUN
brj-24041	87	4	leg	leg	NOUN
brj-24041	87	5	swelling	swell	VERB
brj-24041	87	6	(	(	PUNCT
brj-24041	87	7	knee	knee	NOUN
brj-24041	87	8	joint	joint	ADJ
brj-24041	87	9	area	area	NOUN
brj-24041	87	10	)	)	PUNCT
brj-24041	87	11	following	follow	VERB
brj-24041	87	12	mia	mia	PROPN
brj-24041	87	13	administration	administration	PROPN
brj-24041	87	14	was	be	AUX
brj-24041	87	15	measured	measure	VERB
brj-24041	87	16	precisely	precisely	ADV
brj-24041	87	17	using	use	VERB
brj-24041	87	18	a	a	DET
brj-24041	87	19	vernier	vernier	ADJ
brj-24041	87	20	caliper	caliper	NOUN
brj-24041	87	21	,	,	PUNCT
brj-24041	87	22	and	and	CCONJ
brj-24041	87	23	the	the	DET
brj-24041	87	24	other	other	ADJ
brj-24041	87	25	(	(	PUNCT
brj-24041	87	26	noninjected	noninjected	ADJ
brj-24041	87	27	)	)	PUNCT
brj-24041	87	28	leg	leg	NOUN
brj-24041	87	29	served	serve	VERB
brj-24041	87	30	as	as	ADP
brj-24041	87	31	a	a	DET
brj-24041	87	32	control	control	NOUN
brj-24041	87	33	.	.	PUNCT
brj-24041	88	1	micro	micro	NOUN
brj-24041	88	2	-	-	NOUN
brj-24041	88	3	ct	ct	ADJ
brj-24041	88	4	scanning	scan	VERB
brj-24041	88	5	bruker	bruker	PROPN
brj-24041	88	6	micro	micro	PROPN
brj-24041	88	7	-	-	PROPN
brj-24041	88	8	ct	ct	ADJ
brj-24041	88	9	skyscan	skyscan	ADJ
brj-24041	88	10	1276	1276	NUM
brj-24041	88	11	was	be	AUX
brj-24041	88	12	the	the	DET
brj-24041	88	13	system	system	NOUN
brj-24041	88	14	that	that	PRON
brj-24041	88	15	was	be	AUX
brj-24041	88	16	utilized	utilize	VERB
brj-24041	88	17	in	in	ADP
brj-24041	88	18	order	order	NOUN
brj-24041	88	19	to	to	PART
brj-24041	88	20	scan	scan	VERB
brj-24041	88	21	the	the	DET
brj-24041	88	22	specimens	specimen	NOUN
brj-24041	88	23	.	.	PUNCT
brj-24041	89	1	calibration	calibration	NOUN
brj-24041	89	2	of	of	ADP
brj-24041	89	3	density	density	NOUN
brj-24041	89	4	measurements	measurement	NOUN
brj-24041	89	5	was	be	AUX
brj-24041	89	6	performed	perform	VERB
brj-24041	89	7	using	use	VERB
brj-24041	89	8	the	the	DET
brj-24041	89	9	calcium	calcium	NOUN
brj-24041	89	10	hydroxyapatite	hydroxyapatite	NOUN
brj-24041	89	11	(	(	PUNCT
brj-24041	89	12	caha	caha	NOUN
brj-24041	89	13	)	)	PUNCT
brj-24041	89	14	phantom	phantom	NOUN
brj-24041	89	15	that	that	PRON
brj-24041	89	16	was	be	AUX
brj-24041	89	17	provided	provide	VERB
brj-24041	89	18	by	by	ADP
brj-24041	89	19	the	the	DET
brj-24041	89	20	manufacturer	manufacturer	NOUN
brj-24041	89	21	.	.	PUNCT
brj-24041	90	1	analysis	analysis	NOUN
brj-24041	90	2	of	of	ADP
brj-24041	90	3	the	the	DET
brj-24041	90	4	data	datum	NOUN
brj-24041	90	5	was	be	AUX
brj-24041	90	6	carried	carry	VERB
brj-24041	90	7	out	out	ADP
brj-24041	90	8	by	by	ADP
brj-24041	90	9	the	the	DET
brj-24041	90	10	testing	testing	NOUN
brj-24041	90	11	software	software	NOUN
brj-24041	90	12	provided	provide	VERB
brj-24041	90	13	by	by	ADP
brj-24041	90	14	the	the	DET
brj-24041	90	15	manufacturer	manufacturer	NOUN
brj-24041	90	16	.	.	PUNCT
brj-24041	91	1	nrecon	nrecon	NOUN
brj-24041	91	2	(	(	PUNCT
brj-24041	91	3	version	version	NOUN
brj-24041	91	4	1.7.4.2	1.7.4.2	NUM
brj-24041	91	5	)	)	PUNCT
brj-24041	91	6	was	be	AUX
brj-24041	91	7	successful	successful	ADJ
brj-24041	91	8	in	in	ADP
brj-24041	91	9	completing	complete	VERB
brj-24041	91	10	the	the	DET
brj-24041	91	11	reconstruction	reconstruction	NOUN
brj-24041	91	12	.	.	PUNCT
brj-24041	92	1	an	an	DET
brj-24041	92	2	area	area	NOUN
brj-24041	92	3	of	of	ADP
brj-24041	92	4	interest	interest	NOUN
brj-24041	92	5	(	(	PUNCT
brj-24041	92	6	roi	roi	NOUN
brj-24041	92	7	)	)	PUNCT
brj-24041	92	8	was	be	AUX
brj-24041	92	9	selected	select	VERB
brj-24041	92	10	for	for	ADP
brj-24041	92	11	the	the	DET
brj-24041	92	12	purpose	purpose	NOUN
brj-24041	92	13	of	of	ADP
brj-24041	92	14	conducting	conduct	VERB
brj-24041	92	15	analyses	analysis	NOUN
brj-24041	92	16	of	of	ADP
brj-24041	92	17	the	the	DET
brj-24041	92	18	bone	bone	NOUN
brj-24041	92	19	microarchitecture	microarchitecture	NOUN
brj-24041	92	20	.	.	PUNCT
brj-24041	93	1	bone	bone	NOUN
brj-24041	93	2	morphometry	morphometry	NOUN
brj-24041	93	3	was	be	AUX
brj-24041	93	4	performed	perform	VERB
brj-24041	93	5	on	on	ADP
brj-24041	93	6	the	the	DET
brj-24041	93	7	cortical	cortical	ADJ
brj-24041	93	8	and	and	CCONJ
brj-24041	93	9	epiphyseal	epiphyseal	VERB
brj-24041	93	10	trabecular	trabecular	ADJ
brj-24041	93	11	bone	bone	NOUN
brj-24041	93	12	of	of	ADP
brj-24041	93	13	the	the	DET
brj-24041	93	14	peer	peer	NOUN
brj-24041	93	15	-	-	PUNCT
brj-24041	93	16	reviewed	review	VERB
brj-24041	93	17	article	article	NOUN
brj-24041	93	18	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	94	1	wang	wang	PROPN
brj-24041	94	2	et	et	PROPN
brj-24041	94	3	al	al	PROPN
brj-24041	94	4	.	.	PROPN
brj-24041	94	5	(	(	PUNCT
brj-24041	94	6	2025	2025	NUM
brj-24041	94	7	)	)	PUNCT
brj-24041	94	8	.	.	PUNCT
brj-24041	95	1	“	"	PUNCT
brj-24041	95	2	leaf	leaf	NOUN
brj-24041	95	3	extract	extract	VERB
brj-24041	95	4	anti	anti	ADJ
brj-24041	95	5	-	-	ADJ
brj-24041	95	6	inflammation	inflammation	ADJ
brj-24041	95	7	,	,	PUNCT
brj-24041	95	8	”	"	PUNCT
brj-24041	95	9	bioresources	bioresource	NOUN
brj-24041	95	10	20(1	20(1	NUM
brj-24041	95	11	)	)	PUNCT
brj-24041	95	12	,	,	PUNCT
brj-24041	95	13	956	956	NUM
brj-24041	95	14	-	-	SYM
brj-24041	95	15	971	971	NUM
brj-24041	95	16	.	.	PUNCT
brj-24041	96	1	960	960	NUM
brj-24041	96	2	tibia	tibia	NOUN
brj-24041	96	3	and	and	CCONJ
brj-24041	96	4	femur	femur	ADJ
brj-24041	96	5	in	in	ADP
brj-24041	96	6	accordance	accordance	NOUN
brj-24041	96	7	with	with	ADP
brj-24041	96	8	the	the	DET
brj-24041	96	9	procedures	procedure	NOUN
brj-24041	96	10	that	that	PRON
brj-24041	96	11	were	be	AUX
brj-24041	96	12	established	establish	VERB
brj-24041	96	13	in	in	ADP
brj-24041	96	14	the	the	DET
brj-24041	96	15	past	past	NOUN
brj-24041	96	16	for	for	ADP
brj-24041	96	17	the	the	DET
brj-24041	96	18	parameters	parameter	NOUN
brj-24041	96	19	that	that	PRON
brj-24041	96	20	were	be	AUX
brj-24041	96	21	investigated	investigate	VERB
brj-24041	96	22	.	.	PUNCT
brj-24041	97	1	oxidative	oxidative	ADJ
brj-24041	97	2	stress	stress	NOUN
brj-24041	97	3	biomarkers	biomarker	VERB
brj-24041	97	4	the	the	DET
brj-24041	97	5	spinal	spinal	ADJ
brj-24041	97	6	cord	cord	NOUN
brj-24041	97	7	homogenates	homogenate	NOUN
brj-24041	97	8	were	be	AUX
brj-24041	97	9	centrifuged	centrifuge	VERB
brj-24041	97	10	at	at	ADP
brj-24041	97	11	4	4	NUM
brj-24041	97	12	°	°	ADP
brj-24041	97	13	c	c	NOUN
brj-24041	97	14	and	and	CCONJ
brj-24041	97	15	resulting	result	VERB
brj-24041	97	16	supernatant	supernatant	NOUN
brj-24041	97	17	was	be	AUX
brj-24041	97	18	used	use	VERB
brj-24041	97	19	for	for	ADP
brj-24041	97	20	the	the	DET
brj-24041	97	21	measurement	measurement	NOUN
brj-24041	97	22	of	of	ADP
brj-24041	97	23	mda	mda	PROPN
brj-24041	97	24	and	and	CCONJ
brj-24041	97	25	gsh	gsh	PROPN
brj-24041	97	26	levels	level	NOUN
brj-24041	97	27	and	and	CCONJ
brj-24041	97	28	sod	sod	NOUN
brj-24041	97	29	activity	activity	NOUN
brj-24041	97	30	via	via	ADP
brj-24041	97	31	commercially	commercially	ADV
brj-24041	97	32	available	available	ADJ
brj-24041	97	33	kits	kit	NOUN
brj-24041	97	34	according	accord	VERB
brj-24041	97	35	to	to	ADP
brj-24041	97	36	the	the	DET
brj-24041	97	37	given	give	VERB
brj-24041	97	38	protocols	protocol	NOUN
brj-24041	97	39	.	.	PUNCT
brj-24041	98	1	enzyme	enzyme	NOUN
brj-24041	98	2	-	-	PUNCT
brj-24041	98	3	linked	link	VERB
brj-24041	98	4	immunosorbent	immunosorbent	NOUN
brj-24041	98	5	assay	assay	PROPN
brj-24041	98	6	(	(	PUNCT
brj-24041	98	7	elisa	elisa	NOUN
brj-24041	98	8	)	)	PUNCT
brj-24041	98	9	the	the	DET
brj-24041	98	10	determination	determination	NOUN
brj-24041	98	11	of	of	ADP
brj-24041	98	12	tnf	tnf	PROPN
brj-24041	98	13	-	-	PUNCT
brj-24041	98	14	α	α	PROPN
brj-24041	98	15	(	(	PUNCT
brj-24041	98	16	tumor	tumor	NOUN
brj-24041	98	17	necrosis	necrosis	NOUN
brj-24041	98	18	factor	factor	NOUN
brj-24041	98	19	-	-	PUNCT
brj-24041	98	20	α	α	NOUN
brj-24041	98	21	)	)	PUNCT
brj-24041	98	22	,	,	PUNCT
brj-24041	98	23	il	il	PROPN
brj-24041	98	24	(	(	PUNCT
brj-24041	98	25	interleukin)-1β	interleukin)-1β	PROPN
brj-24041	98	26	and	and	CCONJ
brj-24041	98	27	il6	il6	NOUN
brj-24041	98	28	were	be	AUX
brj-24041	98	29	performed	perform	VERB
brj-24041	98	30	using	use	VERB
brj-24041	98	31	commercially	commercially	ADV
brj-24041	98	32	available	available	ADJ
brj-24041	98	33	elisa	elisa	NOUN
brj-24041	98	34	kits	kit	NOUN
brj-24041	98	35	as	as	ADP
brj-24041	98	36	per	per	ADP
brj-24041	98	37	manufacturer	manufacturer	NOUN
brj-24041	98	38	’s	’s	PART
brj-24041	98	39	instructions	instruction	NOUN
brj-24041	98	40	.	.	PUNCT
brj-24041	99	1	statistical	statistical	ADJ
brj-24041	99	2	analysis	analysis	NOUN
brj-24041	99	3	all	all	DET
brj-24041	99	4	data	datum	NOUN
brj-24041	99	5	were	be	AUX
brj-24041	99	6	expressed	express	VERB
brj-24041	99	7	as	as	ADP
brj-24041	99	8	mean	mean	NOUN
brj-24041	99	9	±	±	NUM
brj-24041	99	10	standard	standard	ADJ
brj-24041	99	11	deviation	deviation	NOUN
brj-24041	99	12	.	.	PUNCT
brj-24041	100	1	comparisons	comparison	NOUN
brj-24041	100	2	between	between	ADP
brj-24041	100	3	multiple	multiple	ADJ
brj-24041	100	4	groups	group	NOUN
brj-24041	100	5	were	be	AUX
brj-24041	100	6	performed	perform	VERB
brj-24041	100	7	with	with	ADP
brj-24041	100	8	one	one	NUM
brj-24041	100	9	-	-	PUNCT
brj-24041	100	10	way	way	NOUN
brj-24041	100	11	anova	anova	X
brj-24041	100	12	and	and	CCONJ
brj-24041	100	13	post	post	ADJ
brj-24041	100	14	-	-	ADJ
brj-24041	100	15	hoc	hoc	X
brj-24041	100	16	tukey	tukey	NOUN
brj-24041	100	17	’s	’s	PART
brj-24041	100	18	test	test	NOUN
brj-24041	100	19	in	in	ADP
brj-24041	100	20	the	the	DET
brj-24041	100	21	case	case	NOUN
brj-24041	100	22	of	of	ADP
brj-24041	100	23	normal	normal	ADJ
brj-24041	100	24	distribution	distribution	NOUN
brj-24041	100	25	or	or	CCONJ
brj-24041	100	26	the	the	DET
brj-24041	100	27	kruskal	kruskal	NOUN
brj-24041	100	28	–	–	PUNCT
brj-24041	100	29	wallis	wallis	PROPN
brj-24041	100	30	and	and	CCONJ
brj-24041	100	31	post	post	ADJ
brj-24041	100	32	-	-	ADJ
brj-24041	100	33	hoc	hoc	ADJ
brj-24041	100	34	dunn	dunn	PROPN
brj-24041	100	35	tests	test	VERB
brj-24041	100	36	for	for	ADP
brj-24041	100	37	non	non	ADJ
brj-24041	100	38	-	-	ADJ
brj-24041	100	39	normal	normal	ADJ
brj-24041	100	40	distribution	distribution	NOUN
brj-24041	100	41	.	.	PUNCT
brj-24041	101	1	a	a	DET
brj-24041	101	2	p	p	NOUN
brj-24041	101	3	-	-	PUNCT
brj-24041	101	4	value	value	NOUN
brj-24041	101	5	<	<	X
brj-24041	101	6	0.05	0.05	NUM
brj-24041	101	7	was	be	AUX
brj-24041	101	8	considered	consider	VERB
brj-24041	101	9	statistically	statistically	ADV
brj-24041	101	10	significant	significant	ADJ
brj-24041	101	11	(	(	PUNCT
brj-24041	101	12	graphpad	graphpad	NOUN
brj-24041	101	13	prism	prism	NOUN
brj-24041	101	14	version	version	NOUN
brj-24041	101	15	9.4.0	9.4.0	NUM
brj-24041	101	16	for	for	ADP
brj-24041	101	17	windows	window	NOUN
brj-24041	101	18	,	,	PUNCT
brj-24041	101	19	graphpad	graphpad	NOUN
brj-24041	101	20	software	software	NOUN
brj-24041	101	21	,	,	PUNCT
brj-24041	101	22	san	san	PROPN
brj-24041	101	23	diego	diego	PROPN
brj-24041	101	24	,	,	PUNCT
brj-24041	101	25	ca	ca	PROPN
brj-24041	101	26	,	,	PUNCT
brj-24041	101	27	usa	usa	PROPN
brj-24041	101	28	)	)	PUNCT
brj-24041	101	29	.	.	PUNCT
brj-24041	102	1	results	result	NOUN
brj-24041	102	2	and	and	CCONJ
brj-24041	102	3	discussion	discussion	NOUN
brj-24041	102	4	effect	effect	NOUN
brj-24041	102	5	on	on	ADP
brj-24041	102	6	the	the	DET
brj-24041	102	7	viability	viability	NOUN
brj-24041	102	8	of	of	ADP
brj-24041	102	9	mouse	mouse	NOUN
brj-24041	102	10	chondrocytes	chondrocyte	NOUN
brj-24041	102	11	:	:	PUNCT
brj-24041	102	12	in	in	ADP
brj-24041	102	13	vitro	vitro	X
brj-24041	102	14	activity	activity	NOUN
brj-24041	102	15	the	the	DET
brj-24041	102	16	effect	effect	NOUN
brj-24041	102	17	of	of	ADP
brj-24041	102	18	aqde	aqde	ADV
brj-24041	102	19	was	be	AUX
brj-24041	102	20	evaluated	evaluate	VERB
brj-24041	102	21	on	on	ADP
brj-24041	102	22	the	the	DET
brj-24041	102	23	viability	viability	NOUN
brj-24041	102	24	of	of	ADP
brj-24041	102	25	mouse	mouse	NOUN
brj-24041	102	26	chondrocytes	chondrocyte	NOUN
brj-24041	102	27	using	use	VERB
brj-24041	102	28	the	the	DET
brj-24041	102	29	mtt	mtt	NOUN
brj-24041	102	30	assay	assay	VERB
brj-24041	102	31	in	in	ADP
brj-24041	102	32	the	the	DET
brj-24041	102	33	concentration	concentration	NOUN
brj-24041	102	34	of	of	ADP
brj-24041	102	35	0.25	0.25	NUM
brj-24041	102	36	,	,	PUNCT
brj-24041	102	37	0.5	0.5	NUM
brj-24041	102	38	,	,	PUNCT
brj-24041	102	39	1	1	NUM
brj-24041	102	40	,	,	PUNCT
brj-24041	102	41	4	4	NUM
brj-24041	102	42	,	,	PUNCT
brj-24041	102	43	8	8	NUM
brj-24041	102	44	,	,	PUNCT
brj-24041	102	45	and	and	CCONJ
brj-24041	102	46	12	12	NUM
brj-24041	102	47	mg	mg	NOUN
brj-24041	102	48	.	.	PUNCT
brj-24041	103	1	up	up	ADP
brj-24041	103	2	to	to	ADP
brj-24041	103	3	the	the	DET
brj-24041	103	4	concentration	concentration	NOUN
brj-24041	103	5	of	of	ADP
brj-24041	103	6	4	4	NUM
brj-24041	103	7	mg	mg	NUM
brj-24041	103	8	,	,	PUNCT
brj-24041	103	9	the	the	DET
brj-24041	103	10	viability	viability	NOUN
brj-24041	103	11	of	of	ADP
brj-24041	103	12	cells	cell	NOUN
brj-24041	103	13	was	be	AUX
brj-24041	103	14	near	near	ADP
brj-24041	103	15	100	100	NUM
brj-24041	103	16	%	%	NOUN
brj-24041	103	17	,	,	PUNCT
brj-24041	103	18	and	and	CCONJ
brj-24041	103	19	on	on	ADP
brj-24041	103	20	8	8	NUM
brj-24041	103	21	mg	mg	NUM
brj-24041	103	22	,	,	PUNCT
brj-24041	103	23	it	it	PRON
brj-24041	103	24	was	be	AUX
brj-24041	103	25	found	find	VERB
brj-24041	103	26	to	to	PART
brj-24041	103	27	be	be	AUX
brj-24041	103	28	96	96	NUM
brj-24041	103	29	%	%	NOUN
brj-24041	103	30	.	.	PUNCT
brj-24041	104	1	however	however	ADV
brj-24041	104	2	,	,	PUNCT
brj-24041	104	3	upon	upon	SCONJ
brj-24041	104	4	increasing	increase	VERB
brj-24041	104	5	the	the	DET
brj-24041	104	6	concentration	concentration	NOUN
brj-24041	104	7	to	to	ADP
brj-24041	104	8	12	12	NUM
brj-24041	104	9	mg	mg	NOUN
brj-24041	104	10	,	,	PUNCT
brj-24041	104	11	viability	viability	NOUN
brj-24041	104	12	was	be	AUX
brj-24041	104	13	found	find	VERB
brj-24041	104	14	reduced	reduce	VERB
brj-24041	104	15	to	to	ADP
brj-24041	104	16	72	72	NUM
brj-24041	104	17	%	%	NOUN
brj-24041	104	18	.	.	PUNCT
brj-24041	105	1	thus	thus	ADV
brj-24041	105	2	,	,	PUNCT
brj-24041	105	3	subsequent	subsequent	ADJ
brj-24041	105	4	in	in	ADP
brj-24041	105	5	vitro	vitro	X
brj-24041	105	6	experiments	experiment	NOUN
brj-24041	105	7	used	use	VERB
brj-24041	105	8	0.5	0.5	NUM
brj-24041	105	9	,	,	PUNCT
brj-24041	105	10	1	1	NUM
brj-24041	105	11	,	,	PUNCT
brj-24041	105	12	and	and	CCONJ
brj-24041	105	13	4	4	NUM
brj-24041	105	14	mg	mg	NOUN
brj-24041	105	15	concentrations	concentration	NOUN
brj-24041	105	16	.	.	PUNCT
brj-24041	106	1	effect	effect	NOUN
brj-24041	106	2	on	on	ADP
brj-24041	106	3	the	the	DET
brj-24041	106	4	tnf	tnf	PROPN
brj-24041	106	5	-	-	PUNCT
brj-24041	106	6	α	α	ADV
brj-24041	106	7	-	-	PUNCT
brj-24041	106	8	induced	induce	VERB
brj-24041	106	9	abnormal	abnormal	ADJ
brj-24041	106	10	gene	gene	NOUN
brj-24041	106	11	expression	expression	NOUN
brj-24041	106	12	chondrocytes	chondrocyte	NOUN
brj-24041	106	13	,	,	PUNCT
brj-24041	106	14	in	in	ADP
brj-24041	106	15	general	general	ADJ
brj-24041	106	16	,	,	PUNCT
brj-24041	106	17	have	have	VERB
brj-24041	106	18	a	a	DET
brj-24041	106	19	high	high	ADJ
brj-24041	106	20	degree	degree	NOUN
brj-24041	106	21	of	of	ADP
brj-24041	106	22	sensitivity	sensitivity	NOUN
brj-24041	106	23	to	to	ADP
brj-24041	106	24	tnf	tnf	PROPN
brj-24041	106	25	-	-	PUNCT
brj-24041	106	26	α	α	PROPN
brj-24041	106	27	,	,	PUNCT
brj-24041	106	28	a	a	DET
brj-24041	106	29	cytokine	cytokine	NOUN
brj-24041	106	30	that	that	PRON
brj-24041	106	31	inhibits	inhibit	VERB
brj-24041	106	32	the	the	DET
brj-24041	106	33	production	production	NOUN
brj-24041	106	34	of	of	ADP
brj-24041	106	35	aggrecan	aggrecan	PROPN
brj-24041	106	36	and	and	CCONJ
brj-24041	106	37	collagen	collagen	PROPN
brj-24041	106	38	type	type	PROPN
brj-24041	106	39	ii	ii	PROPN
brj-24041	106	40	,	,	PUNCT
brj-24041	106	41	hence	hence	ADV
brj-24041	106	42	fostering	foster	VERB
brj-24041	106	43	the	the	DET
brj-24041	106	44	development	development	NOUN
brj-24041	106	45	of	of	ADP
brj-24041	106	46	osteoarthritis	osteoarthritis	NOUN
brj-24041	106	47	(	(	PUNCT
brj-24041	106	48	oa	oa	NOUN
brj-24041	106	49	)	)	PUNCT
brj-24041	106	50	.	.	PUNCT
brj-24041	107	1	to	to	PART
brj-24041	107	2	evaluate	evaluate	VERB
brj-24041	107	3	the	the	DET
brj-24041	107	4	protective	protective	ADJ
brj-24041	107	5	role	role	NOUN
brj-24041	107	6	of	of	ADP
brj-24041	107	7	aqde	aqde	ADV
brj-24041	107	8	in	in	ADP
brj-24041	107	9	chondrocytes	chondrocyte	NOUN
brj-24041	107	10	that	that	PRON
brj-24041	107	11	were	be	AUX
brj-24041	107	12	treated	treat	VERB
brj-24041	107	13	with	with	ADP
brj-24041	107	14	tnf	tnf	PROPN
brj-24041	107	15	-	-	PUNCT
brj-24041	107	16	α	α	PROPN
brj-24041	107	17	,	,	PUNCT
brj-24041	107	18	the	the	DET
brj-24041	107	19	real	real	ADJ
brj-24041	107	20	-	-	PUNCT
brj-24041	107	21	time	time	NOUN
brj-24041	107	22	polymerase	polymerase	NOUN
brj-24041	107	23	chain	chain	NOUN
brj-24041	107	24	reaction	reaction	NOUN
brj-24041	107	25	(	(	PUNCT
brj-24041	107	26	rt	rt	NOUN
brj-24041	107	27	-	-	PUNCT
brj-24041	107	28	pcr	pcr	NOUN
brj-24041	107	29	)	)	PUNCT
brj-24041	107	30	was	be	AUX
brj-24041	107	31	utilized	utilize	VERB
brj-24041	107	32	to	to	PART
brj-24041	107	33	analyze	analyze	VERB
brj-24041	107	34	the	the	DET
brj-24041	107	35	impact	impact	NOUN
brj-24041	107	36	of	of	ADP
brj-24041	107	37	aqde	aqde	ADV
brj-24041	107	38	on	on	ADP
brj-24041	107	39	aggrecan	aggrecan	PROPN
brj-24041	107	40	and	and	CCONJ
brj-24041	107	41	collagen	collagen	NOUN
brj-24041	107	42	type	type	PROPN
brj-24041	107	43	ii	ii	PROPN
brj-24041	107	44	.	.	PUNCT
brj-24041	108	1	following	follow	VERB
brj-24041	108	2	that	that	PRON
brj-24041	108	3	,	,	PUNCT
brj-24041	108	4	the	the	DET
brj-24041	108	5	influence	influence	NOUN
brj-24041	108	6	of	of	ADP
brj-24041	108	7	aqde	aqde	ADV
brj-24041	108	8	was	be	AUX
brj-24041	108	9	investigated	investigate	VERB
brj-24041	108	10	in	in	ADP
brj-24041	108	11	the	the	DET
brj-24041	108	12	production	production	NOUN
brj-24041	108	13	of	of	ADP
brj-24041	108	14	il-1β	il-1β	PROPN
brj-24041	108	15	,	,	PUNCT
brj-24041	108	16	il-6	il-6	PRON
brj-24041	108	17	,	,	PUNCT
brj-24041	108	18	mmp13	mmp13	NOUN
brj-24041	108	19	,	,	PUNCT
brj-24041	108	20	and	and	CCONJ
brj-24041	108	21	ptgs2	ptgs2	PROPN
brj-24041	108	22	in	in	ADP
brj-24041	108	23	chondrocytes	chondrocyte	NOUN
brj-24041	108	24	,	,	PUNCT
brj-24041	108	25	which	which	PRON
brj-24041	108	26	was	be	AUX
brj-24041	108	27	triggered	trigger	VERB
brj-24041	108	28	by	by	ADP
brj-24041	108	29	tnf	tnf	PROPN
brj-24041	108	30	-	-	PUNCT
brj-24041	108	31	α	α	NOUN
brj-24041	108	32	activity	activity	NOUN
brj-24041	108	33	.	.	PUNCT
brj-24041	109	1	as	as	SCONJ
brj-24041	109	2	shown	show	VERB
brj-24041	109	3	in	in	ADP
brj-24041	109	4	fig	fig	NOUN
brj-24041	109	5	.	.	PUNCT
brj-24041	110	1	2	2	NUM
brj-24041	110	2	,	,	PUNCT
brj-24041	110	3	the	the	DET
brj-24041	110	4	cells	cell	NOUN
brj-24041	110	5	treated	treat	VERB
brj-24041	110	6	with	with	ADP
brj-24041	110	7	tnf	tnf	PROPN
brj-24041	110	8	-	-	PUNCT
brj-24041	110	9	a	a	NOUN
brj-24041	110	10	,	,	PUNCT
brj-24041	110	11	compared	compare	VERB
brj-24041	110	12	with	with	ADP
brj-24041	110	13	the	the	DET
brj-24041	110	14	control	control	NOUN
brj-24041	110	15	,	,	PUNCT
brj-24041	110	16	tnfα	tnfα	NOUN
brj-24041	110	17	caused	cause	VERB
brj-24041	110	18	significant	significant	ADJ
brj-24041	110	19	increases	increase	NOUN
brj-24041	110	20	in	in	ADP
brj-24041	110	21	mrna	mrna	PROPN
brj-24041	110	22	levels	level	NOUN
brj-24041	110	23	of	of	ADP
brj-24041	110	24	il-1β	il-1β	PROPN
brj-24041	110	25	,	,	PUNCT
brj-24041	110	26	il-6	il-6	PRON
brj-24041	110	27	,	,	PUNCT
brj-24041	110	28	mmp-13	mmp-13	PROPN
brj-24041	110	29	,	,	PUNCT
brj-24041	110	30	and	and	CCONJ
brj-24041	110	31	ptgs2	ptgs2	PROPN
brj-24041	110	32	and	and	CCONJ
brj-24041	110	33	inhibited	inhibit	VERB
brj-24041	110	34	acan	acan	NOUN
brj-24041	110	35	and	and	CCONJ
brj-24041	110	36	col2a	col2a	NUM
brj-24041	110	37	gene	gene	NOUN
brj-24041	110	38	expression	expression	NOUN
brj-24041	110	39	.	.	PUNCT
brj-24041	111	1	however	however	ADV
brj-24041	111	2	,	,	PUNCT
brj-24041	111	3	after	after	ADP
brj-24041	111	4	administration	administration	NOUN
brj-24041	111	5	of	of	ADP
brj-24041	111	6	aqde	aqde	ADV
brj-24041	111	7	,	,	PUNCT
brj-24041	111	8	the	the	DET
brj-24041	111	9	level	level	NOUN
brj-24041	111	10	of	of	ADP
brj-24041	111	11	these	these	DET
brj-24041	111	12	genes	gene	NOUN
brj-24041	111	13	was	be	AUX
brj-24041	111	14	found	find	VERB
brj-24041	111	15	to	to	PART
brj-24041	111	16	be	be	AUX
brj-24041	111	17	restored	restore	VERB
brj-24041	111	18	to	to	ADP
brj-24041	111	19	near	near	ADV
brj-24041	111	20	to	to	ADP
brj-24041	111	21	normal	normal	ADJ
brj-24041	111	22	in	in	ADP
brj-24041	111	23	a	a	DET
brj-24041	111	24	concentration	concentration	NOUN
brj-24041	111	25	dependent	dependent	ADJ
brj-24041	111	26	manner	manner	NOUN
brj-24041	111	27	.	.	PUNCT
brj-24041	112	1	peer	peer	NOUN
brj-24041	112	2	-	-	PUNCT
brj-24041	112	3	reviewed	review	VERB
brj-24041	112	4	article	article	NOUN
brj-24041	112	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	112	6	wang	wang	PROPN
brj-24041	112	7	et	et	PROPN
brj-24041	112	8	al	al	PROPN
brj-24041	112	9	.	.	PROPN
brj-24041	113	1	(	(	PUNCT
brj-24041	113	2	2025	2025	NUM
brj-24041	113	3	)	)	PUNCT
brj-24041	113	4	.	.	PUNCT
brj-24041	114	1	“	"	PUNCT
brj-24041	114	2	leaf	leaf	NOUN
brj-24041	114	3	extract	extract	VERB
brj-24041	114	4	anti	anti	ADJ
brj-24041	114	5	-	-	ADJ
brj-24041	114	6	inflammation	inflammation	ADJ
brj-24041	114	7	,	,	PUNCT
brj-24041	114	8	”	"	PUNCT
brj-24041	114	9	bioresources	bioresource	NOUN
brj-24041	114	10	20(1	20(1	NUM
brj-24041	114	11	)	)	PUNCT
brj-24041	114	12	,	,	PUNCT
brj-24041	114	13	956	956	NUM
brj-24041	114	14	-	-	SYM
brj-24041	114	15	971	971	NUM
brj-24041	114	16	.	.	PUNCT
brj-24041	115	1	961	961	NUM
brj-24041	115	2	fig	fig	NOUN
brj-24041	115	3	.	.	PUNCT
brj-24041	116	1	1	1	X
brj-24041	116	2	.	.	X
brj-24041	116	3	effect	effect	NOUN
brj-24041	116	4	of	of	ADP
brj-24041	116	5	aqde	aqde	ADV
brj-24041	116	6	on	on	ADP
brj-24041	116	7	the	the	DET
brj-24041	116	8	gene	gene	NOUN
brj-24041	116	9	expression	expression	NOUN
brj-24041	116	10	of	of	ADP
brj-24041	116	11	a	a	PRON
brj-24041	116	12	)	)	PUNCT
brj-24041	116	13	acgan	acgan	ADJ
brj-24041	116	14	,	,	PUNCT
brj-24041	116	15	b	b	NOUN
brj-24041	116	16	)	)	PUNCT
brj-24041	116	17	col2a	col2a	NOUN
brj-24041	116	18	,	,	PUNCT
brj-24041	116	19	c	c	NOUN
brj-24041	116	20	)	)	PUNCT
brj-24041	116	21	il-1β	il-1β	PROPN
brj-24041	116	22	,	,	PUNCT
brj-24041	116	23	d	d	NOUN
brj-24041	116	24	)	)	PUNCT
brj-24041	116	25	il-6	il-6	NUM
brj-24041	116	26	,	,	PUNCT
brj-24041	116	27	e	e	NOUN
brj-24041	116	28	)	)	PUNCT
brj-24041	116	29	mmp13	mmp13	NOUN
brj-24041	116	30	,	,	PUNCT
brj-24041	116	31	and	and	CCONJ
brj-24041	116	32	f	f	X
brj-24041	116	33	)	)	PUNCT
brj-24041	116	34	ptgs2	ptgs2	PROPN
brj-24041	116	35	mouse	mouse	NOUN
brj-24041	116	36	chondrocytes	chondrocyte	NOUN
brj-24041	116	37	using	use	VERB
brj-24041	116	38	the	the	DET
brj-24041	116	39	qrt	qrt	ADJ
brj-24041	116	40	-	-	PUNCT
brj-24041	116	41	pcr	pcr	ADJ
brj-24041	116	42	analysis	analysis	NOUN
brj-24041	116	43	.	.	PUNCT
brj-24041	117	1	#	#	ADJ
brj-24041	117	2	p<0.05	p<0.05	NOUN
brj-24041	117	3	vs.	vs.	ADP
brj-24041	117	4	control	control	NOUN
brj-24041	117	5	and	and	CCONJ
brj-24041	117	6	*	*	NOUN
brj-24041	117	7	*	*	PROPN
brj-24041	117	8	p<0.01	p<0.01	PROPN
brj-24041	117	9	vs.	vs.	ADP
brj-24041	117	10	tnf	tnf	PROPN
brj-24041	117	11	-	-	PUNCT
brj-24041	117	12	α	α	PROPN
brj-24041	117	13	group	group	NOUN
brj-24041	117	14	.	.	PUNCT
brj-24041	118	1	data	datum	NOUN
brj-24041	118	2	are	be	AUX
brj-24041	118	3	presented	present	VERB
brj-24041	118	4	as	as	SCONJ
brj-24041	118	5	means	mean	VERB
brj-24041	118	6	±	±	NUM
brj-24041	118	7	sem	sem	ADJ
brj-24041	118	8	effect	effect	NOUN
brj-24041	118	9	on	on	ADP
brj-24041	118	10	inflammatory	inflammatory	ADJ
brj-24041	118	11	mediators	mediator	NOUN
brj-24041	118	12	and	and	CCONJ
brj-24041	118	13	protein	protein	NOUN
brj-24041	118	14	synthesis	synthesis	NOUN
brj-24041	118	15	induced	induce	VERB
brj-24041	118	16	by	by	ADP
brj-24041	118	17	tnf	tnf	PROPN
brj-24041	118	18	-	-	PUNCT
brj-24041	118	19	α	α	PROPN
brj-24041	118	20	in	in	ADP
brj-24041	118	21	mouse	mouse	NOUN
brj-24041	118	22	chondrocytes	chondrocyte	NOUN
brj-24041	118	23	as	as	SCONJ
brj-24041	118	24	shown	show	VERB
brj-24041	118	25	in	in	ADP
brj-24041	118	26	fig	fig	NOUN
brj-24041	118	27	.	.	PUNCT
brj-24041	119	1	2	2	NUM
brj-24041	119	2	(	(	PUNCT
brj-24041	119	3	a	a	PRON
brj-24041	119	4	,	,	PUNCT
brj-24041	119	5	b	b	NOUN
brj-24041	119	6	,	,	PUNCT
brj-24041	119	7	and	and	CCONJ
brj-24041	119	8	c	c	X
brj-24041	119	9	)	)	PUNCT
brj-24041	119	10	,	,	PUNCT
brj-24041	119	11	in	in	ADP
brj-24041	119	12	qrt	qrt	ADJ
brj-24041	119	13	-	-	PUNCT
brj-24041	119	14	pcr	pcr	NOUN
brj-24041	119	15	analysis	analysis	NOUN
brj-24041	119	16	,	,	PUNCT
brj-24041	119	17	tnf	tnf	PROPN
brj-24041	119	18	-	-	PUNCT
brj-24041	119	19	α	α	PROPN
brj-24041	119	20	caused	cause	VERB
brj-24041	119	21	significant	significant	ADJ
brj-24041	119	22	decrease	decrease	NOUN
brj-24041	119	23	in	in	ADP
brj-24041	119	24	the	the	DET
brj-24041	119	25	mrna	mrna	NOUN
brj-24041	119	26	expression	expression	NOUN
brj-24041	119	27	of	of	ADP
brj-24041	119	28	bcl-2	bcl-2	NOUN
brj-24041	119	29	,	,	PUNCT
brj-24041	119	30	cdk1	cdk1	PROPN
brj-24041	119	31	,	,	PUNCT
brj-24041	119	32	and	and	CCONJ
brj-24041	119	33	cyclin	cyclin	NOUN
brj-24041	119	34	(	(	PUNCT
brj-24041	119	35	ccnd	ccnd	PROPN
brj-24041	119	36	)	)	PUNCT
brj-24041	119	37	.	.	PUNCT
brj-24041	120	1	however	however	ADV
brj-24041	120	2	,	,	PUNCT
brj-24041	120	3	the	the	DET
brj-24041	120	4	level	level	NOUN
brj-24041	120	5	of	of	ADP
brj-24041	120	6	these	these	DET
brj-24041	120	7	genes	gene	NOUN
brj-24041	120	8	was	be	AUX
brj-24041	120	9	found	find	VERB
brj-24041	120	10	increased	increase	VERB
brj-24041	120	11	and	and	CCONJ
brj-24041	120	12	found	find	VERB
brj-24041	120	13	restored	restore	VERB
brj-24041	120	14	near	near	ADV
brj-24041	120	15	to	to	ADP
brj-24041	120	16	normal	normal	ADJ
brj-24041	120	17	in	in	ADP
brj-24041	120	18	aqde	aqde	ADV
brj-24041	120	19	treated	treat	VERB
brj-24041	120	20	group	group	NOUN
brj-24041	120	21	.	.	PUNCT
brj-24041	121	1	the	the	DET
brj-24041	121	2	maximum	maximum	ADJ
brj-24041	121	3	benefit	benefit	NOUN
brj-24041	121	4	was	be	AUX
brj-24041	121	5	achieved	achieve	VERB
brj-24041	121	6	in	in	ADP
brj-24041	121	7	the	the	DET
brj-24041	121	8	case	case	NOUN
brj-24041	121	9	of	of	ADP
brj-24041	121	10	4	4	NUM
brj-24041	121	11	mg	mg	NOUN
brj-24041	121	12	treated	treat	VERB
brj-24041	121	13	group	group	NOUN
brj-24041	121	14	of	of	ADP
brj-24041	121	15	aqde	aqde	NOUN
brj-24041	121	16	.	.	PUNCT
brj-24041	122	1	effect	effect	NOUN
brj-24041	122	2	on	on	ADP
brj-24041	122	3	apoptosis	apoptosis	NOUN
brj-24041	122	4	of	of	ADP
brj-24041	122	5	chondrocytes	chondrocyte	NOUN
brj-24041	122	6	in	in	ADP
brj-24041	122	7	response	response	NOUN
brj-24041	122	8	of	of	ADP
brj-24041	122	9	the	the	DET
brj-24041	122	10	effect	effect	NOUN
brj-24041	122	11	of	of	ADP
brj-24041	122	12	aqde	aqde	ADV
brj-24041	122	13	on	on	ADP
brj-24041	122	14	the	the	DET
brj-24041	122	15	bcl-2	bcl-2	NOUN
brj-24041	122	16	gene	gene	NOUN
brj-24041	122	17	,	,	PUNCT
brj-24041	122	18	the	the	DET
brj-24041	122	19	effect	effect	NOUN
brj-24041	122	20	of	of	ADP
brj-24041	122	21	aqde	aqde	ADV
brj-24041	122	22	on	on	ADP
brj-24041	122	23	the	the	DET
brj-24041	122	24	apoptosis	apoptosis	NOUN
brj-24041	122	25	of	of	ADP
brj-24041	122	26	mouse	mouse	NOUN
brj-24041	122	27	chondrocytes	chondrocyte	NOUN
brj-24041	122	28	was	be	AUX
brj-24041	122	29	identified	identify	VERB
brj-24041	122	30	using	use	VERB
brj-24041	122	31	flow	flow	NOUN
brj-24041	122	32	cytometry	cytometry	NOUN
brj-24041	122	33	analysis	analysis	NOUN
brj-24041	122	34	.	.	PUNCT
brj-24041	123	1	the	the	DET
brj-24041	123	2	results	result	NOUN
brj-24041	123	3	have	have	AUX
brj-24041	123	4	been	be	AUX
brj-24041	123	5	presented	present	VERB
brj-24041	123	6	in	in	ADP
brj-24041	123	7	fig	fig	NOUN
brj-24041	123	8	.	.	PUNCT
brj-24041	124	1	2d	2d	NOUN
brj-24041	124	2	.	.	PUNCT
brj-24041	125	1	the	the	DET
brj-24041	125	2	rate	rate	NOUN
brj-24041	125	3	of	of	ADP
brj-24041	125	4	apoptosis	apoptosis	NOUN
brj-24041	125	5	was	be	AUX
brj-24041	125	6	increased	increase	VERB
brj-24041	125	7	after	after	ADP
brj-24041	125	8	the	the	DET
brj-24041	125	9	induction	induction	NOUN
brj-24041	125	10	of	of	ADP
brj-24041	125	11	tnf	tnf	PROPN
brj-24041	125	12	-	-	PUNCT
brj-24041	125	13	α	α	PROPN
brj-24041	125	14	,	,	PUNCT
brj-24041	125	15	while	while	SCONJ
brj-24041	125	16	upon	upon	SCONJ
brj-24041	125	17	introduction	introduction	NOUN
brj-24041	125	18	of	of	ADP
brj-24041	125	19	aqde	aqde	NOUN
brj-24041	125	20	,	,	PUNCT
brj-24041	125	21	the	the	DET
brj-24041	125	22	apoptosis	apoptosis	NOUN
brj-24041	125	23	was	be	AUX
brj-24041	125	24	found	find	VERB
brj-24041	125	25	to	to	PART
brj-24041	125	26	be	be	AUX
brj-24041	125	27	significantly	significantly	ADV
brj-24041	125	28	reduced	reduce	VERB
brj-24041	125	29	in	in	ADP
brj-24041	125	30	a	a	DET
brj-24041	125	31	concentration	concentration	NOUN
brj-24041	125	32	-	-	PUNCT
brj-24041	125	33	dependent	dependent	ADJ
brj-24041	125	34	manner	manner	NOUN
brj-24041	125	35	.	.	PUNCT
brj-24041	126	1	peer	peer	NOUN
brj-24041	126	2	-	-	PUNCT
brj-24041	126	3	reviewed	review	VERB
brj-24041	126	4	article	article	NOUN
brj-24041	126	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	126	6	wang	wang	PROPN
brj-24041	126	7	et	et	PROPN
brj-24041	126	8	al	al	PROPN
brj-24041	126	9	.	.	PROPN
brj-24041	127	1	(	(	PUNCT
brj-24041	127	2	2025	2025	NUM
brj-24041	127	3	)	)	PUNCT
brj-24041	127	4	.	.	PUNCT
brj-24041	128	1	“	"	PUNCT
brj-24041	128	2	leaf	leaf	NOUN
brj-24041	128	3	extract	extract	VERB
brj-24041	128	4	anti	anti	ADJ
brj-24041	128	5	-	-	ADJ
brj-24041	128	6	inflammation	inflammation	ADJ
brj-24041	128	7	,	,	PUNCT
brj-24041	128	8	”	"	PUNCT
brj-24041	128	9	bioresources	bioresource	NOUN
brj-24041	128	10	20(1	20(1	NUM
brj-24041	128	11	)	)	PUNCT
brj-24041	128	12	,	,	PUNCT
brj-24041	128	13	956	956	NUM
brj-24041	128	14	-	-	SYM
brj-24041	128	15	971	971	NUM
brj-24041	128	16	.	.	PUNCT
brj-24041	129	1	962	962	NUM
brj-24041	129	2	fig	fig	NOUN
brj-24041	129	3	.	.	PUNCT
brj-24041	130	1	2	2	X
brj-24041	130	2	.	.	X
brj-24041	130	3	effect	effect	NOUN
brj-24041	130	4	of	of	ADP
brj-24041	130	5	aqde	aqde	ADV
brj-24041	130	6	on	on	ADP
brj-24041	130	7	the	the	DET
brj-24041	130	8	mrna	mrna	NOUN
brj-24041	130	9	expression	expression	NOUN
brj-24041	130	10	of	of	ADP
brj-24041	130	11	a	a	DET
brj-24041	130	12	)	)	PUNCT
brj-24041	130	13	bcl2	bcl2	PROPN
brj-24041	130	14	,	,	PUNCT
brj-24041	130	15	cdk1	cdk1	PROPN
brj-24041	130	16	,	,	PUNCT
brj-24041	130	17	and	and	CCONJ
brj-24041	130	18	c	c	X
brj-24041	130	19	)	)	PUNCT
brj-24041	130	20	ccnd	ccnd	NOUN
brj-24041	130	21	using	use	VERB
brj-24041	130	22	the	the	DET
brj-24041	130	23	qrtpcr	qrtpcr	ADJ
brj-24041	130	24	analysis	analysis	NOUN
brj-24041	130	25	,	,	PUNCT
brj-24041	130	26	d	d	NOUN
brj-24041	130	27	)	)	PUNCT
brj-24041	130	28	rate	rate	NOUN
brj-24041	130	29	of	of	ADP
brj-24041	130	30	apoptosis	apoptosis	NOUN
brj-24041	130	31	of	of	ADP
brj-24041	130	32	mouse	mouse	NOUN
brj-24041	130	33	chondrocytes	chondrocyte	NOUN
brj-24041	130	34	using	use	VERB
brj-24041	130	35	flow	flow	NOUN
brj-24041	130	36	cytometry	cytometry	NOUN
brj-24041	130	37	analysis	analysis	NOUN
brj-24041	130	38	.	.	PUNCT
brj-24041	131	1	#	#	ADJ
brj-24041	131	2	p<0.05	p<0.05	NOUN
brj-24041	131	3	vs.	vs.	ADP
brj-24041	131	4	control	control	NOUN
brj-24041	131	5	and	and	CCONJ
brj-24041	131	6	*	*	NOUN
brj-24041	131	7	*	*	PROPN
brj-24041	131	8	p<0.01	p<0.01	PROPN
brj-24041	131	9	vs.	vs.	ADP
brj-24041	131	10	tnf	tnf	PROPN
brj-24041	131	11	-	-	PUNCT
brj-24041	131	12	α	α	PROPN
brj-24041	131	13	group	group	NOUN
brj-24041	131	14	.	.	PUNCT
brj-24041	132	1	data	datum	NOUN
brj-24041	132	2	are	be	AUX
brj-24041	132	3	presented	present	VERB
brj-24041	132	4	as	as	SCONJ
brj-24041	132	5	means	mean	VERB
brj-24041	132	6	±	±	NUM
brj-24041	132	7	sem	sem	PROPN
brj-24041	132	8	.	.	PUNCT
brj-24041	133	1	effect	effect	NOUN
brj-24041	133	2	on	on	ADP
brj-24041	133	3	mrna	mrna	PROPN
brj-24041	133	4	level	level	NOUN
brj-24041	133	5	of	of	ADP
brj-24041	133	6	cox-2	cox-2	NUM
brj-24041	133	7	and	and	CCONJ
brj-24041	133	8	nf	nf	NOUN
brj-24041	133	9	-	-	PUNCT
brj-24041	133	10	κb	κb	NOUN
brj-24041	133	11	in	in	ADP
brj-24041	133	12	mouse	mouse	NOUN
brj-24041	133	13	chondrocytes	chondrocyte	NOUN
brj-24041	133	14	finally	finally	ADV
brj-24041	133	15	,	,	PUNCT
brj-24041	133	16	in	in	ADP
brj-24041	133	17	light	light	NOUN
brj-24041	133	18	of	of	ADP
brj-24041	133	19	the	the	DET
brj-24041	133	20	anti	anti	ADJ
brj-24041	133	21	-	-	ADJ
brj-24041	133	22	inflammatory	inflammatory	ADJ
brj-24041	133	23	properties	property	NOUN
brj-24041	133	24	of	of	ADP
brj-24041	133	25	aqde	aqde	ADV
brj-24041	133	26	on	on	ADP
brj-24041	133	27	mouse	mouse	NOUN
brj-24041	133	28	chondrocytes	chondrocyte	NOUN
brj-24041	133	29	,	,	PUNCT
brj-24041	133	30	its	its	PRON
brj-24041	133	31	impact	impact	NOUN
brj-24041	133	32	on	on	ADP
brj-24041	133	33	the	the	DET
brj-24041	133	34	protein	protein	NOUN
brj-24041	133	35	expression	expression	NOUN
brj-24041	133	36	of	of	ADP
brj-24041	133	37	cox-2	cox-2	NUM
brj-24041	133	38	and	and	CCONJ
brj-24041	133	39	nf	nf	NOUN
brj-24041	133	40	-	-	PUNCT
brj-24041	133	41	κb	κb	PROPN
brj-24041	133	42	was	be	AUX
brj-24041	133	43	examined	examine	VERB
brj-24041	133	44	.	.	PUNCT
brj-24041	134	1	figure	figure	NOUN
brj-24041	134	2	3	3	NUM
brj-24041	134	3	illustrates	illustrate	VERB
brj-24041	134	4	that	that	SCONJ
brj-24041	134	5	the	the	DET
brj-24041	134	6	mrna	mrna	PROPN
brj-24041	134	7	expression	expression	NOUN
brj-24041	134	8	levels	level	NOUN
brj-24041	134	9	of	of	ADP
brj-24041	134	10	both	both	PRON
brj-24041	134	11	cox-2	cox-2	ADJ
brj-24041	134	12	and	and	CCONJ
brj-24041	134	13	nf	nf	NOUN
brj-24041	134	14	-	-	PUNCT
brj-24041	134	15	κb	κb	NOUN
brj-24041	134	16	were	be	AUX
brj-24041	134	17	significantly	significantly	ADV
brj-24041	134	18	elevated	elevate	VERB
brj-24041	134	19	in	in	ADP
brj-24041	134	20	tnf	tnf	PROPN
brj-24041	134	21	-	-	PUNCT
brj-24041	134	22	α	α	PROPN
brj-24041	134	23	induced	induce	VERB
brj-24041	134	24	chondrocytes	chondrocyte	NOUN
brj-24041	134	25	compared	compare	VERB
brj-24041	134	26	to	to	ADP
brj-24041	134	27	the	the	DET
brj-24041	134	28	control	control	NOUN
brj-24041	134	29	group	group	NOUN
brj-24041	134	30	.	.	PUNCT
brj-24041	135	1	subsequent	subsequent	ADJ
brj-24041	135	2	to	to	ADP
brj-24041	135	3	the	the	DET
brj-24041	135	4	administration	administration	NOUN
brj-24041	135	5	of	of	ADP
brj-24041	135	6	aqde	aqde	ADV
brj-24041	135	7	,	,	PUNCT
brj-24041	135	8	the	the	DET
brj-24041	135	9	mrna	mrna	PROPN
brj-24041	135	10	expression	expression	NOUN
brj-24041	135	11	of	of	ADP
brj-24041	135	12	these	these	DET
brj-24041	135	13	mediators	mediator	NOUN
brj-24041	135	14	exhibited	exhibit	VERB
brj-24041	135	15	a	a	DET
brj-24041	135	16	considerable	considerable	ADJ
brj-24041	135	17	reduction	reduction	NOUN
brj-24041	135	18	in	in	ADP
brj-24041	135	19	a	a	DET
brj-24041	135	20	concentration	concentration	NOUN
brj-24041	135	21	-	-	PUNCT
brj-24041	135	22	dependent	dependent	ADJ
brj-24041	135	23	manner	manner	NOUN
brj-24041	135	24	.	.	PUNCT
brj-24041	136	1	the	the	DET
brj-24041	136	2	4	4	NUM
brj-24041	136	3	mg	mg	NOUN
brj-24041	136	4	aqdetreated	aqdetreate	VERB
brj-24041	136	5	group	group	NOUN
brj-24041	136	6	exhibited	exhibit	VERB
brj-24041	136	7	the	the	DET
brj-24041	136	8	most	most	ADV
brj-24041	136	9	significant	significant	ADJ
brj-24041	136	10	reduction	reduction	NOUN
brj-24041	136	11	of	of	ADP
brj-24041	136	12	these	these	DET
brj-24041	136	13	mediators	mediator	NOUN
brj-24041	136	14	compared	compare	VERB
brj-24041	136	15	to	to	ADP
brj-24041	136	16	the	the	DET
brj-24041	136	17	tnf	tnf	PROPN
brj-24041	136	18	-	-	PUNCT
brj-24041	136	19	α	α	PROPN
brj-24041	136	20	treated	treat	VERB
brj-24041	136	21	group	group	NOUN
brj-24041	136	22	.	.	PUNCT
brj-24041	137	1	peer	peer	NOUN
brj-24041	137	2	-	-	PUNCT
brj-24041	137	3	reviewed	review	VERB
brj-24041	137	4	article	article	NOUN
brj-24041	137	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	137	6	wang	wang	PROPN
brj-24041	137	7	et	et	PROPN
brj-24041	137	8	al	al	PROPN
brj-24041	137	9	.	.	PROPN
brj-24041	138	1	(	(	PUNCT
brj-24041	138	2	2025	2025	NUM
brj-24041	138	3	)	)	PUNCT
brj-24041	138	4	.	.	PUNCT
brj-24041	139	1	“	"	PUNCT
brj-24041	139	2	leaf	leaf	NOUN
brj-24041	139	3	extract	extract	VERB
brj-24041	139	4	anti	anti	ADJ
brj-24041	139	5	-	-	ADJ
brj-24041	139	6	inflammation	inflammation	ADJ
brj-24041	139	7	,	,	PUNCT
brj-24041	139	8	”	"	PUNCT
brj-24041	139	9	bioresources	bioresource	NOUN
brj-24041	139	10	20(1	20(1	NUM
brj-24041	139	11	)	)	PUNCT
brj-24041	139	12	,	,	PUNCT
brj-24041	139	13	956	956	NUM
brj-24041	139	14	-	-	SYM
brj-24041	139	15	971	971	NUM
brj-24041	139	16	.	.	PUNCT
brj-24041	140	1	963	963	NUM
brj-24041	140	2	fig	fig	NOUN
brj-24041	140	3	.	.	PUNCT
brj-24041	141	1	3	3	X
brj-24041	141	2	.	.	X
brj-24041	141	3	effect	effect	NOUN
brj-24041	141	4	of	of	ADP
brj-24041	141	5	aqde	aqde	ADV
brj-24041	141	6	on	on	ADP
brj-24041	141	7	the	the	DET
brj-24041	141	8	mrna	mrna	NOUN
brj-24041	141	9	expression	expression	NOUN
brj-24041	141	10	of	of	ADP
brj-24041	141	11	a	a	PRON
brj-24041	141	12	)	)	PUNCT
brj-24041	141	13	cox-2	cox-2	NOUN
brj-24041	141	14	and	and	CCONJ
brj-24041	141	15	b	b	NOUN
brj-24041	141	16	)	)	PUNCT
brj-24041	141	17	nf	nf	NOUN
brj-24041	141	18	-	-	PUNCT
brj-24041	141	19	κb	κb	NOUN
brj-24041	141	20	using	use	VERB
brj-24041	141	21	qrt	qrt	ADJ
brj-24041	141	22	-	-	PUNCT
brj-24041	141	23	pcr	pcr	ADJ
brj-24041	141	24	analysis	analysis	NOUN
brj-24041	141	25	.	.	PUNCT
brj-24041	142	1	#	#	ADJ
brj-24041	142	2	p<0.05	p<0.05	NOUN
brj-24041	142	3	vs.	vs.	ADP
brj-24041	142	4	control	control	NOUN
brj-24041	142	5	and	and	CCONJ
brj-24041	142	6	*	*	NOUN
brj-24041	142	7	*	*	PROPN
brj-24041	142	8	p<0.01	p<0.01	PROPN
brj-24041	142	9	vs.	vs.	ADP
brj-24041	142	10	tnf	tnf	PROPN
brj-24041	142	11	-	-	PUNCT
brj-24041	142	12	α	α	PROPN
brj-24041	142	13	group	group	NOUN
brj-24041	142	14	.	.	PUNCT
brj-24041	143	1	data	datum	NOUN
brj-24041	143	2	are	be	AUX
brj-24041	143	3	presented	present	VERB
brj-24041	143	4	as	as	SCONJ
brj-24041	143	5	means	mean	VERB
brj-24041	143	6	±	±	NUM
brj-24041	143	7	sem	sem	PROPN
brj-24041	143	8	.	.	PUNCT
brj-24041	144	1	effect	effect	NOUN
brj-24041	144	2	on	on	ADP
brj-24041	144	3	pain	pain	NOUN
brj-24041	144	4	response	response	NOUN
brj-24041	144	5	and	and	CCONJ
brj-24041	144	6	knee	knee	NOUN
brj-24041	144	7	swelling	swell	VERB
brj-24041	144	8	in	in	ADP
brj-24041	144	9	vivo	vivo	NOUN
brj-24041	144	10	figure	figure	NOUN
brj-24041	144	11	4a	4a	NOUN
brj-24041	144	12	illustrates	illustrate	VERB
brj-24041	144	13	that	that	SCONJ
brj-24041	144	14	in	in	ADP
brj-24041	144	15	the	the	DET
brj-24041	144	16	oa	oa	PROPN
brj-24041	144	17	group	group	NOUN
brj-24041	144	18	,	,	PUNCT
brj-24041	144	19	mia	mia	PROPN
brj-24041	144	20	elicited	elicit	VERB
brj-24041	144	21	considerable	considerable	ADJ
brj-24041	144	22	mechanical	mechanical	ADJ
brj-24041	144	23	allodynia	allodynia	NOUN
brj-24041	144	24	(	(	PUNCT
brj-24041	144	25	as	as	SCONJ
brj-24041	144	26	measured	measure	VERB
brj-24041	144	27	by	by	ADP
brj-24041	144	28	the	the	DET
brj-24041	144	29	von	von	PROPN
brj-24041	144	30	frey	frey	PROPN
brj-24041	144	31	test	test	PROPN
brj-24041	144	32	)	)	PUNCT
brj-24041	144	33	in	in	ADP
brj-24041	144	34	the	the	DET
brj-24041	144	35	ipsilateral	ipsilateral	ADJ
brj-24041	144	36	paw	paw	NOUN
brj-24041	144	37	relative	relative	NOUN
brj-24041	144	38	to	to	ADP
brj-24041	144	39	the	the	DET
brj-24041	144	40	control	control	NOUN
brj-24041	144	41	group	group	NOUN
brj-24041	144	42	.	.	PUNCT
brj-24041	145	1	the	the	DET
brj-24041	145	2	rats	rat	NOUN
brj-24041	145	3	administered	administer	VERB
brj-24041	145	4	mia	mia	PROPN
brj-24041	145	5	exhibited	exhibit	VERB
brj-24041	145	6	a	a	DET
brj-24041	145	7	sustained	sustained	ADJ
brj-24041	145	8	reduction	reduction	NOUN
brj-24041	145	9	in	in	ADP
brj-24041	145	10	withdrawal	withdrawal	NOUN
brj-24041	145	11	threshold	threshold	NOUN
brj-24041	145	12	in	in	ADP
brj-24041	145	13	the	the	DET
brj-24041	145	14	ipsilateral	ipsilateral	ADJ
brj-24041	145	15	paw	paw	NOUN
brj-24041	145	16	for	for	ADP
brj-24041	145	17	up	up	ADP
brj-24041	145	18	to	to	PART
brj-24041	145	19	28	28	NUM
brj-24041	145	20	days	day	NOUN
brj-24041	145	21	post	post	NOUN
brj-24041	145	22	-	-	NOUN
brj-24041	145	23	administration	administration	NOUN
brj-24041	145	24	.	.	PUNCT
brj-24041	146	1	this	this	DET
brj-24041	146	2	study	study	NOUN
brj-24041	146	3	assessed	assess	VERB
brj-24041	146	4	paw	paw	NOUN
brj-24041	146	5	and	and	CCONJ
brj-24041	146	6	knee	knee	NOUN
brj-24041	146	7	withdrawal	withdrawal	NOUN
brj-24041	146	8	thresholds	threshold	VERB
brj-24041	146	9	90	90	NUM
brj-24041	146	10	min	min	NOUN
brj-24041	146	11	after	after	ADP
brj-24041	146	12	aqde	aqde	ADJ
brj-24041	146	13	administration	administration	NOUN
brj-24041	146	14	.	.	PUNCT
brj-24041	147	1	in	in	ADP
brj-24041	147	2	the	the	DET
brj-24041	147	3	evaluation	evaluation	NOUN
brj-24041	147	4	of	of	ADP
brj-24041	147	5	mechanical	mechanical	ADJ
brj-24041	147	6	allodynia	allodynia	PROPN
brj-24041	147	7	,	,	PUNCT
brj-24041	147	8	rats	rat	NOUN
brj-24041	147	9	treated	treat	VERB
brj-24041	147	10	with	with	ADP
brj-24041	147	11	aqde	aqde	ADV
brj-24041	147	12	exhibited	exhibit	VERB
brj-24041	147	13	a	a	DET
brj-24041	147	14	notable	notable	ADJ
brj-24041	147	15	rise	rise	NOUN
brj-24041	147	16	in	in	ADP
brj-24041	147	17	the	the	DET
brj-24041	147	18	withdrawal	withdrawal	NOUN
brj-24041	147	19	threshold	threshold	NOUN
brj-24041	147	20	of	of	ADP
brj-24041	147	21	the	the	DET
brj-24041	147	22	ipsilateral	ipsilateral	ADJ
brj-24041	147	23	paw	paw	NOUN
brj-24041	147	24	following	follow	VERB
brj-24041	147	25	acute	acute	ADJ
brj-24041	147	26	oral	oral	ADJ
brj-24041	147	27	treatment	treatment	NOUN
brj-24041	147	28	.	.	PUNCT
brj-24041	148	1	furthermore	furthermore	ADV
brj-24041	148	2	,	,	PUNCT
brj-24041	148	3	on	on	ADP
brj-24041	148	4	the	the	DET
brj-24041	148	5	21st	21st	ADJ
brj-24041	148	6	and	and	CCONJ
brj-24041	148	7	28th	28th	ADJ
brj-24041	148	8	days	day	NOUN
brj-24041	148	9	,	,	PUNCT
brj-24041	148	10	aqde	aqde	ADV
brj-24041	148	11	showed	show	VERB
brj-24041	148	12	a	a	DET
brj-24041	148	13	substantial	substantial	ADJ
brj-24041	148	14	improvement	improvement	NOUN
brj-24041	148	15	in	in	ADP
brj-24041	148	16	allodynia	allodynia	NOUN
brj-24041	148	17	in	in	ADP
brj-24041	148	18	rats	rat	NOUN
brj-24041	148	19	compared	compare	VERB
brj-24041	148	20	to	to	ADP
brj-24041	148	21	the	the	DET
brj-24041	148	22	oa	oa	PROPN
brj-24041	148	23	group	group	NOUN
brj-24041	148	24	.	.	PUNCT
brj-24041	149	1	the	the	DET
brj-24041	149	2	impact	impact	NOUN
brj-24041	149	3	of	of	ADP
brj-24041	149	4	aqde	aqde	ADV
brj-24041	149	5	on	on	ADP
brj-24041	149	6	the	the	DET
brj-24041	149	7	knee	knee	NOUN
brj-24041	149	8	joint	joint	ADJ
brj-24041	149	9	thickness	thickness	NOUN
brj-24041	149	10	of	of	ADP
brj-24041	149	11	rats	rat	NOUN
brj-24041	149	12	was	be	AUX
brj-24041	149	13	also	also	ADV
brj-24041	149	14	studied	study	VERB
brj-24041	149	15	.	.	PUNCT
brj-24041	150	1	as	as	SCONJ
brj-24041	150	2	illustrated	illustrate	VERB
brj-24041	150	3	in	in	ADP
brj-24041	150	4	fig	fig	NOUN
brj-24041	150	5	.	.	PUNCT
brj-24041	151	1	4b	4b	PROPN
brj-24041	151	2	,	,	PUNCT
brj-24041	151	3	at	at	ADP
brj-24041	151	4	the	the	DET
brj-24041	151	5	end	end	NOUN
brj-24041	151	6	of	of	ADP
brj-24041	151	7	the	the	DET
brj-24041	151	8	study	study	NOUN
brj-24041	151	9	duration	duration	NOUN
brj-24041	151	10	,	,	PUNCT
brj-24041	151	11	the	the	DET
brj-24041	151	12	knee	knee	NOUN
brj-24041	151	13	joint	joint	ADJ
brj-24041	151	14	thickness	thickness	NOUN
brj-24041	151	15	of	of	ADP
brj-24041	151	16	the	the	DET
brj-24041	151	17	animals	animal	NOUN
brj-24041	151	18	in	in	ADP
brj-24041	151	19	each	each	DET
brj-24041	151	20	group	group	NOUN
brj-24041	151	21	was	be	AUX
brj-24041	151	22	assessed	assess	VERB
brj-24041	151	23	using	use	VERB
brj-24041	151	24	a	a	DET
brj-24041	151	25	digital	digital	ADJ
brj-24041	151	26	vernier	vernier	PROPN
brj-24041	151	27	caliper	caliper	NOUN
brj-24041	151	28	.	.	PUNCT
brj-24041	152	1	following	follow	VERB
brj-24041	152	2	the	the	DET
brj-24041	152	3	administration	administration	NOUN
brj-24041	152	4	of	of	ADP
brj-24041	152	5	aqde	aqde	ADV
brj-24041	152	6	,	,	PUNCT
brj-24041	152	7	a	a	DET
brj-24041	152	8	reduction	reduction	NOUN
brj-24041	152	9	in	in	ADP
brj-24041	152	10	knee	knee	NOUN
brj-24041	152	11	swelling	swelling	NOUN
brj-24041	152	12	triggered	trigger	VERB
brj-24041	152	13	by	by	ADP
brj-24041	152	14	mia	mia	PROPN
brj-24041	152	15	was	be	AUX
brj-24041	152	16	detected	detect	VERB
brj-24041	152	17	in	in	ADP
brj-24041	152	18	a	a	DET
brj-24041	152	19	dose	dose	NOUN
brj-24041	152	20	-	-	PUNCT
brj-24041	152	21	dependent	dependent	ADJ
brj-24041	152	22	manner	manner	NOUN
brj-24041	152	23	.	.	PUNCT
brj-24041	153	1	fig	fig	NOUN
brj-24041	153	2	.	.	PUNCT
brj-24041	154	1	4	4	NUM
brj-24041	154	2	effect	effect	NOUN
brj-24041	154	3	of	of	ADP
brj-24041	154	4	aqde	aqde	ADV
brj-24041	154	5	on	on	ADP
brj-24041	154	6	a	a	DET
brj-24041	154	7	)	)	PUNCT
brj-24041	154	8	mechanical	mechanical	ADJ
brj-24041	154	9	allodynia	allodynia	NOUN
brj-24041	154	10	using	use	VERB
brj-24041	154	11	von	von	PROPN
brj-24041	154	12	frey	frey	PROPN
brj-24041	154	13	test	test	PROPN
brj-24041	154	14	,	,	PUNCT
brj-24041	154	15	b	b	X
brj-24041	154	16	)	)	PUNCT
brj-24041	154	17	knee	knee	NOUN
brj-24041	154	18	joint	joint	ADJ
brj-24041	154	19	thickness	thickness	NOUN
brj-24041	154	20	of	of	ADP
brj-24041	154	21	mia	mia	PROPN
brj-24041	154	22	rats	rat	NOUN
brj-24041	154	23	.	.	PUNCT
brj-24041	155	1	#	#	ADJ
brj-24041	155	2	p<0.05	p<0.05	NOUN
brj-24041	155	3	vs.	vs.	ADP
brj-24041	155	4	control	control	NOUN
brj-24041	155	5	and	and	CCONJ
brj-24041	155	6	*	*	NOUN
brj-24041	155	7	*	*	PUNCT
brj-24041	155	8	p<0.01	p<0.01	ADP
brj-24041	155	9	vs.	vs.	ADP
brj-24041	155	10	oa	oa	PROPN
brj-24041	155	11	group	group	NOUN
brj-24041	155	12	.	.	PUNCT
brj-24041	156	1	data	datum	NOUN
brj-24041	156	2	are	be	AUX
brj-24041	156	3	presented	present	VERB
brj-24041	156	4	as	as	SCONJ
brj-24041	156	5	means	mean	VERB
brj-24041	156	6	±	±	NUM
brj-24041	156	7	sem	sem	PROPN
brj-24041	156	8	.	.	PUNCT
brj-24041	157	1	peer	peer	NOUN
brj-24041	157	2	-	-	PUNCT
brj-24041	157	3	reviewed	review	VERB
brj-24041	157	4	article	article	NOUN
brj-24041	157	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	157	6	wang	wang	PROPN
brj-24041	157	7	et	et	PROPN
brj-24041	157	8	al	al	PROPN
brj-24041	157	9	.	.	PROPN
brj-24041	158	1	(	(	PUNCT
brj-24041	158	2	2025	2025	NUM
brj-24041	158	3	)	)	PUNCT
brj-24041	158	4	.	.	PUNCT
brj-24041	159	1	“	"	PUNCT
brj-24041	159	2	leaf	leaf	NOUN
brj-24041	159	3	extract	extract	VERB
brj-24041	159	4	anti	anti	ADJ
brj-24041	159	5	-	-	ADJ
brj-24041	159	6	inflammation	inflammation	ADJ
brj-24041	159	7	,	,	PUNCT
brj-24041	159	8	”	"	PUNCT
brj-24041	159	9	bioresources	bioresource	NOUN
brj-24041	159	10	20(1	20(1	NUM
brj-24041	159	11	)	)	PUNCT
brj-24041	159	12	,	,	PUNCT
brj-24041	159	13	956	956	NUM
brj-24041	159	14	-	-	SYM
brj-24041	159	15	971	971	NUM
brj-24041	159	16	.	.	PUNCT
brj-24041	160	1	964	964	NUM
brj-24041	160	2	effect	effect	NOUN
brj-24041	160	3	on	on	ADP
brj-24041	160	4	rat	rat	NOUN
brj-24041	160	5	knee	knee	NOUN
brj-24041	160	6	joint	joint	NOUN
brj-24041	160	7	in	in	ADP
brj-24041	160	8	micro	micro	NOUN
brj-24041	160	9	-	-	NOUN
brj-24041	160	10	ct	ct	ADJ
brj-24041	160	11	scanning	scanning	NOUN
brj-24041	160	12	in	in	ADP
brj-24041	160	13	the	the	DET
brj-24041	160	14	micro	micro	NOUN
brj-24041	160	15	-	-	NOUN
brj-24041	160	16	ct	ct	PROPN
brj-24041	160	17	(	(	PUNCT
brj-24041	160	18	μct	μct	NOUN
brj-24041	160	19	)	)	PUNCT
brj-24041	160	20	investigation	investigation	NOUN
brj-24041	160	21	of	of	ADP
brj-24041	160	22	rat	rat	NOUN
brj-24041	160	23	joints	joint	NOUN
brj-24041	160	24	,	,	PUNCT
brj-24041	160	25	rats	rat	NOUN
brj-24041	160	26	in	in	ADP
brj-24041	160	27	the	the	DET
brj-24041	160	28	oa	oa	PROPN
brj-24041	160	29	group	group	NOUN
brj-24041	160	30	exhibited	exhibit	VERB
brj-24041	160	31	a	a	DET
brj-24041	160	32	substantial	substantial	ADJ
brj-24041	160	33	reduction	reduction	NOUN
brj-24041	160	34	in	in	ADP
brj-24041	160	35	bv	bv	PROPN
brj-24041	160	36	/	/	SYM
brj-24041	160	37	tv	tv	NOUN
brj-24041	160	38	,	,	PUNCT
brj-24041	160	39	bs	bs	NOUN
brj-24041	160	40	/	/	SYM
brj-24041	160	41	tv	tv	NOUN
brj-24041	160	42	,	,	PUNCT
brj-24041	160	43	tb	tb	NOUN
brj-24041	160	44	.	.	PUNCT
brj-24041	160	45	n	n	CCONJ
brj-24041	160	46	,	,	PUNCT
brj-24041	160	47	and	and	CCONJ
brj-24041	160	48	bmd	bmd	PROPN
brj-24041	160	49	compared	compare	VERB
brj-24041	160	50	to	to	ADP
brj-24041	160	51	the	the	DET
brj-24041	160	52	control	control	NOUN
brj-24041	160	53	group	group	NOUN
brj-24041	160	54	.	.	PUNCT
brj-24041	161	1	the	the	DET
brj-24041	161	2	diminished	diminished	ADJ
brj-24041	161	3	values	value	NOUN
brj-24041	161	4	suggest	suggest	VERB
brj-24041	161	5	that	that	SCONJ
brj-24041	161	6	rats	rat	NOUN
brj-24041	161	7	exhibited	exhibit	VERB
brj-24041	161	8	considerable	considerable	ADJ
brj-24041	161	9	joint	joint	ADJ
brj-24041	161	10	bone	bone	NOUN
brj-24041	161	11	loss	loss	NOUN
brj-24041	161	12	following	follow	VERB
brj-24041	161	13	mia	mia	PROPN
brj-24041	161	14	treatment	treatment	PROPN
brj-24041	161	15	.	.	PUNCT
brj-24041	162	1	the	the	DET
brj-24041	162	2	oa	oa	PROPN
brj-24041	162	3	model	model	NOUN
brj-24041	162	4	demonstrated	demonstrate	VERB
brj-24041	162	5	a	a	DET
brj-24041	162	6	considerable	considerable	ADJ
brj-24041	162	7	increase	increase	NOUN
brj-24041	162	8	in	in	ADP
brj-24041	162	9	tb	tb	NOUN
brj-24041	162	10	.	.	PUNCT
brj-24041	163	1	pf	pf	PROPN
brj-24041	163	2	,	,	PUNCT
brj-24041	163	3	tb	tb	NOUN
brj-24041	163	4	.	.	PUNCT
brj-24041	163	5	sp	sp	NOUN
brj-24041	163	6	,	,	PUNCT
brj-24041	163	7	and	and	CCONJ
brj-24041	163	8	smi	smi	PROPN
brj-24041	163	9	in	in	ADP
brj-24041	163	10	the	the	DET
brj-24041	163	11	joints	joint	NOUN
brj-24041	163	12	of	of	ADP
brj-24041	163	13	rats	rat	NOUN
brj-24041	163	14	,	,	PUNCT
brj-24041	163	15	with	with	ADP
brj-24041	163	16	no	no	DET
brj-24041	163	17	notable	notable	ADJ
brj-24041	163	18	alteration	alteration	NOUN
brj-24041	163	19	in	in	ADP
brj-24041	163	20	tb	tb	NOUN
brj-24041	163	21	,	,	PUNCT
brj-24041	163	22	indicating	indicate	VERB
brj-24041	163	23	a	a	DET
brj-24041	163	24	transition	transition	NOUN
brj-24041	163	25	in	in	ADP
brj-24041	163	26	trabecular	trabecular	ADJ
brj-24041	163	27	bone	bone	NOUN
brj-24041	163	28	morphology	morphology	NOUN
brj-24041	163	29	from	from	ADP
brj-24041	163	30	plate	plate	NOUN
brj-24041	163	31	-	-	PUNCT
brj-24041	163	32	like	like	ADJ
brj-24041	163	33	to	to	PART
brj-24041	163	34	rod	rod	VERB
brj-24041	163	35	-	-	PUNCT
brj-24041	163	36	like	like	ADJ
brj-24041	163	37	structures	structure	NOUN
brj-24041	163	38	.	.	PUNCT
brj-24041	164	1	however	however	ADV
brj-24041	164	2	,	,	PUNCT
brj-24041	164	3	after	after	ADP
brj-24041	164	4	administration	administration	NOUN
brj-24041	164	5	of	of	ADP
brj-24041	164	6	aqde	aqde	ADV
brj-24041	164	7	,	,	PUNCT
brj-24041	164	8	these	these	DET
brj-24041	164	9	bone	bone	NOUN
brj-24041	164	10	joints	joint	NOUN
brj-24041	164	11	parameters	parameter	NOUN
brj-24041	164	12	were	be	AUX
brj-24041	164	13	found	find	VERB
brj-24041	164	14	to	to	PART
brj-24041	164	15	be	be	AUX
brj-24041	164	16	significantly	significantly	ADV
brj-24041	164	17	improved	improve	VERB
brj-24041	164	18	in	in	ADP
brj-24041	164	19	a	a	DET
brj-24041	164	20	dose	dose	NOUN
brj-24041	164	21	-	-	PUNCT
brj-24041	164	22	dependent	dependent	ADJ
brj-24041	164	23	manner	manner	NOUN
brj-24041	164	24	.	.	PUNCT
brj-24041	165	1	the	the	DET
brj-24041	165	2	most	most	ADV
brj-24041	165	3	prominent	prominent	ADJ
brj-24041	165	4	activity	activity	NOUN
brj-24041	165	5	was	be	AUX
brj-24041	165	6	achieved	achieve	VERB
brj-24041	165	7	in	in	ADP
brj-24041	165	8	the	the	DET
brj-24041	165	9	case	case	NOUN
brj-24041	165	10	of	of	ADP
brj-24041	165	11	50	50	NUM
brj-24041	165	12	mg	mg	NUM
brj-24041	165	13	/	/	SYM
brj-24041	165	14	kg	kg	PROPN
brj-24041	165	15	treated	treat	VERB
brj-24041	165	16	rats	rat	NOUN
brj-24041	165	17	in	in	ADP
brj-24041	165	18	comparison	comparison	NOUN
brj-24041	165	19	to	to	ADP
brj-24041	165	20	oa	oa	PROPN
brj-24041	165	21	group	group	NOUN
brj-24041	165	22	.	.	PUNCT
brj-24041	166	1	table	table	NOUN
brj-24041	166	2	1	1	NUM
brj-24041	166	3	.	.	PUNCT
brj-24041	167	1	parameters	parameter	NOUN
brj-24041	167	2	of	of	ADP
brj-24041	167	3	rat	rat	NOUN
brj-24041	167	4	knee	knee	NOUN
brj-24041	167	5	joint	joint	NOUN
brj-24041	167	6	obtained	obtain	VERB
brj-24041	167	7	after	after	ADP
brj-24041	167	8	the	the	DET
brj-24041	167	9	micro	micro	NOUN
brj-24041	167	10	-	-	NOUN
brj-24041	167	11	ct	ct	ADJ
brj-24041	167	12	scanning	scan	VERB
brj-24041	167	13	indexes	index	NOUN
brj-24041	167	14	control	control	NOUN
brj-24041	167	15	oa	oa	VERB
brj-24041	167	16	10	10	NUM
brj-24041	167	17	mg	mg	PROPN
brj-24041	167	18	/	/	SYM
brj-24041	167	19	kg	kg	PROPN
brj-24041	167	20	25	25	NUM
brj-24041	167	21	mg	mg	PROPN
brj-24041	167	22	/	/	SYM
brj-24041	167	23	kg	kg	PROPN
brj-24041	167	24	50	50	NUM
brj-24041	167	25	mg	mg	PROPN
brj-24041	167	26	/	/	SYM
brj-24041	167	27	kg	kg	PROPN
brj-24041	167	28	bv	bv	PROPN
brj-24041	167	29	/	/	SYM
brj-24041	167	30	tv	tv	NOUN
brj-24041	167	31	(	(	PUNCT
brj-24041	167	32	mm3	mm3	PROPN
brj-24041	167	33	)	)	PUNCT
brj-24041	167	34	47.16	47.16	NUM
brj-24041	167	35	±	±	NUM
brj-24041	167	36	4.52	4.52	NUM
brj-24041	167	37	32.53	32.53	NUM
brj-24041	167	38	±	±	NUM
brj-24041	167	39	3.61	3.61	NUM
brj-24041	167	40	#	#	NOUN
brj-24041	167	41	37.32	37.32	NUM
brj-24041	167	42	±	±	NUM
brj-24041	167	43	3.53	3.53	NUM
brj-24041	167	44	*	*	SYM
brj-24041	167	45	39.81	39.81	NUM
brj-24041	167	46	±	±	NUM
brj-24041	167	47	4.21	4.21	NUM
brj-24041	167	48	*	*	SYM
brj-24041	167	49	43.54	43.54	NUM
brj-24041	167	50	±	±	NUM
brj-24041	167	51	4.24	4.24	NUM
brj-24041	167	52	*	*	PUNCT
brj-24041	167	53	*	*	PUNCT
brj-24041	167	54	bs	bs	X
brj-24041	167	55	/	/	SYM
brj-24041	167	56	tv	tv	NOUN
brj-24041	167	57	(	(	PUNCT
brj-24041	167	58	mm3	mm3	PROPN
brj-24041	167	59	)	)	PUNCT
brj-24041	167	60	14.32	14.32	NUM
brj-24041	167	61	±	±	NUM
brj-24041	167	62	2.11	2.11	NUM
brj-24041	167	63	10.34	10.34	NUM
brj-24041	167	64	±	±	NUM
brj-24041	167	65	2.34	2.34	NUM
brj-24041	167	66	#	#	NOUN
brj-24041	167	67	11.26	11.26	NUM
brj-24041	167	68	±	±	NUM
brj-24041	167	69	2.53	2.53	NUM
brj-24041	167	70	*	*	SYM
brj-24041	167	71	12.78	12.78	NUM
brj-24041	167	72	±	±	NUM
brj-24041	167	73	2.33	2.33	NUM
brj-24041	167	74	*	*	NUM
brj-24041	167	75	13.23	13.23	NUM
brj-24041	167	76	±	±	NUM
brj-24041	167	77	2.55	2.55	NUM
brj-24041	167	78	*	*	NOUN
brj-24041	167	79	tb.th	tb.th	NOUN
brj-24041	167	80	(	(	PUNCT
brj-24041	167	81	mm	mm	NOUN
brj-24041	167	82	)	)	PUNCT
brj-24041	167	83	0.17	0.17	NUM
brj-24041	167	84	±	±	NUM
brj-24041	167	85	0.04	0.04	NUM
brj-24041	167	86	0.12	0.12	NUM
brj-24041	167	87	±	±	NUM
brj-24041	167	88	0.05	0.05	NUM
brj-24041	167	89	#	#	NOUN
brj-24041	167	90	0.13	0.13	NUM
brj-24041	167	91	±	±	NUM
brj-24041	167	92	0.05	0.05	NUM
brj-24041	167	93	*	*	PUNCT
brj-24041	167	94	0.15	0.15	NUM
brj-24041	167	95	±	±	NOUN
brj-24041	167	96	0.04	0.04	NUM
brj-24041	167	97	*	*	PUNCT
brj-24041	167	98	0.16	0.16	NUM
brj-24041	167	99	±	±	NUM
brj-24041	167	100	0.05	0.05	NUM
brj-24041	167	101	*	*	NOUN
brj-24041	167	102	tb.n	tb.n	NOUN
brj-24041	167	103	(	(	PUNCT
brj-24041	167	104	mm-1	mm-1	NOUN
brj-24041	167	105	)	)	PUNCT
brj-24041	167	106	3.76	3.76	NUM
brj-24041	167	107	±	±	NUM
brj-24041	167	108	0.33	0.33	NUM
brj-24041	167	109	2.43	2.43	NUM
brj-24041	167	110	±	±	NUM
brj-24041	168	1	0.26	0.26	NUM
brj-24041	168	2	#	#	NOUN
brj-24041	168	3	2.78	2.78	NUM
brj-24041	168	4	±	±	NOUN
brj-24041	168	5	0.38	0.38	NUM
brj-24041	168	6	*	*	NUM
brj-24041	168	7	3.12	3.12	NUM
brj-24041	168	8	±	±	NUM
brj-24041	168	9	0.41	0.41	NUM
brj-24041	168	10	*	*	NOUN
brj-24041	168	11	3.37±	3.37±	NUM
brj-24041	168	12	0.52	0.52	NUM
brj-24041	168	13	*	*	PUNCT
brj-24041	169	1	tb.sp	tb.sp	PROPN
brj-24041	169	2	(	(	PUNCT
brj-24041	169	3	mm	mm	NOUN
brj-24041	169	4	)	)	PUNCT
brj-24041	169	5	0.25	0.25	NUM
brj-24041	169	6	±	±	NUM
brj-24041	169	7	0.02	0.02	NUM
brj-24041	169	8	0.32	0.32	NUM
brj-24041	169	9	±	±	NUM
brj-24041	169	10	0.02	0.02	NUM
brj-24041	169	11	#	#	NOUN
brj-24041	169	12	0.31	0.31	NUM
brj-24041	169	13	±	±	NUM
brj-24041	169	14	0.03	0.03	NUM
brj-24041	169	15	*	*	SYM
brj-24041	169	16	0.29	0.29	NUM
brj-24041	169	17	±	±	NUM
brj-24041	169	18	0.03	0.03	NUM
brj-24041	169	19	*	*	NOUN
brj-24041	169	20	0.28	0.28	NUM
brj-24041	169	21	±	±	NUM
brj-24041	169	22	0.04	0.04	NUM
brj-24041	169	23	*	*	PUNCT
brj-24041	169	24	tb.pf	tb.pf	PROPN
brj-24041	169	25	(	(	PUNCT
brj-24041	169	26	mm-1	mm-1	NOUN
brj-24041	169	27	)	)	PUNCT
brj-24041	169	28	0.99	0.99	NUM
brj-24041	169	29	±	±	NUM
brj-24041	169	30	0.14	0.14	NUM
brj-24041	169	31	6.12	6.12	NUM
brj-24041	169	32	±	±	NUM
brj-24041	169	33	1.05	1.05	NUM
brj-24041	169	34	#	#	NOUN
brj-24041	169	35	4.56	4.56	NUM
brj-24041	169	36	±	±	NUM
brj-24041	169	37	0.85	0.85	NUM
brj-24041	169	38	*	*	NUM
brj-24041	169	39	3.52	3.52	NUM
brj-24041	169	40	±	±	NUM
brj-24041	169	41	0.73	0.73	NUM
brj-24041	169	42	*	*	NUM
brj-24041	169	43	2.89	2.89	NUM
brj-24041	169	44	±	±	NUM
brj-24041	169	45	0.72	0.72	NUM
brj-24041	169	46	*	*	PUNCT
brj-24041	169	47	smi	smi	PROPN
brj-24041	169	48	0.34	0.34	NUM
brj-24041	169	49	±	±	NUM
brj-24041	169	50	0.05	0.05	NUM
brj-24041	169	51	1.34	1.34	NUM
brj-24041	169	52	±	±	NUM
brj-24041	169	53	0.44	0.44	NUM
brj-24041	169	54	#	#	NOUN
brj-24041	169	55	1.22	1.22	NUM
brj-24041	169	56	±	±	NUM
brj-24041	169	57	0.42	0.42	NUM
brj-24041	169	58	*	*	NUM
brj-24041	169	59	1.05	1.05	NUM
brj-24041	169	60	±	±	NUM
brj-24041	169	61	0.34	0.34	NUM
brj-24041	169	62	*	*	NUM
brj-24041	169	63	0.87	0.87	NUM
brj-24041	169	64	±	±	NUM
brj-24041	169	65	0.19	0.19	NUM
brj-24041	169	66	*	*	PUNCT
brj-24041	169	67	bmd	bmd	PROPN
brj-24041	169	68	(	(	PUNCT
brj-24041	169	69	g*mm-3	g*mm-3	ADV
brj-24041	169	70	)	)	PUNCT
brj-24041	169	71	0.83	0.83	NUM
brj-24041	169	72	±	±	NUM
brj-24041	169	73	0.08	0.08	NUM
brj-24041	169	74	0.51±	0.51±	NOUN
brj-24041	169	75	0.06	0.06	NUM
brj-24041	169	76	#	#	NOUN
brj-24041	169	77	0.57	0.57	NUM
brj-24041	169	78	±	±	NUM
brj-24041	169	79	0.07	0.07	NUM
brj-24041	169	80	*	*	PUNCT
brj-24041	169	81	0.66	0.66	NUM
brj-24041	169	82	±	±	NUM
brj-24041	169	83	0.08	0.08	NUM
brj-24041	169	84	*	*	SYM
brj-24041	169	85	0.69	0.69	NUM
brj-24041	169	86	±	±	NUM
brj-24041	169	87	0.08	0.08	NUM
brj-24041	169	88	*	*	PUNCT
brj-24041	169	89	note	note	NOUN
brj-24041	169	90	:	:	PUNCT
brj-24041	169	91	tb.sbp=	tb.sbp=	PRON
brj-24041	169	92	tibial	tibial	ADJ
brj-24041	169	93	subchondral	subchondral	ADJ
brj-24041	169	94	bone	bone	NOUN
brj-24041	169	95	;	;	PUNCT
brj-24041	169	96	fm.cg	fm.cg	ADJ
brj-24041	169	97	femoral	femoral	ADJ
brj-24041	169	98	cartilage	cartilage	NOUN
brj-24041	169	99	;	;	PUNCT
brj-24041	169	100	tb.cg	tb.cg	VERB
brj-24041	169	101	:	:	PUNCT
brj-24041	169	102	tibial	tibial	ADJ
brj-24041	169	103	cartilage	cartilage	NOUN
brj-24041	169	104	;	;	PUNCT
brj-24041	169	105	#	#	NUM
brj-24041	169	106	p<0.05	p<0.05	NOUN
brj-24041	169	107	vs.	vs.	ADP
brj-24041	169	108	control	control	NOUN
brj-24041	169	109	and	and	CCONJ
brj-24041	169	110	*	*	NOUN
brj-24041	169	111	*	*	PUNCT
brj-24041	169	112	p<0.01	p<0.01	ADP
brj-24041	169	113	vs.	vs.	ADP
brj-24041	169	114	oa	oa	PROPN
brj-24041	169	115	group	group	NOUN
brj-24041	169	116	.	.	PUNCT
brj-24041	170	1	data	datum	NOUN
brj-24041	170	2	are	be	AUX
brj-24041	170	3	presented	present	VERB
brj-24041	170	4	as	as	SCONJ
brj-24041	170	5	means	mean	VERB
brj-24041	170	6	±	±	NUM
brj-24041	170	7	sem	sem	PROPN
brj-24041	170	8	.	.	PUNCT
brj-24041	171	1	effect	effect	NOUN
brj-24041	171	2	on	on	ADP
brj-24041	171	3	oxidative	oxidative	ADJ
brj-24041	171	4	stress	stress	NOUN
brj-24041	171	5	indices	index	NOUN
brj-24041	171	6	and	and	CCONJ
brj-24041	171	7	proinflammatory	proinflammatory	ADJ
brj-24041	171	8	cytokines	cytokine	NOUN
brj-24041	171	9	production	production	NOUN
brj-24041	171	10	in	in	ADP
brj-24041	171	11	serum	serum	NOUN
brj-24041	171	12	in	in	ADP
brj-24041	171	13	the	the	DET
brj-24041	171	14	next	next	ADJ
brj-24041	171	15	part	part	NOUN
brj-24041	171	16	of	of	ADP
brj-24041	171	17	the	the	DET
brj-24041	171	18	study	study	NOUN
brj-24041	171	19	,	,	PUNCT
brj-24041	171	20	the	the	DET
brj-24041	171	21	effect	effect	NOUN
brj-24041	171	22	of	of	ADP
brj-24041	171	23	aqde	aqde	ADV
brj-24041	171	24	was	be	AUX
brj-24041	171	25	estimated	estimate	VERB
brj-24041	171	26	on	on	ADP
brj-24041	171	27	various	various	ADJ
brj-24041	171	28	indices	index	NOUN
brj-24041	171	29	of	of	ADP
brj-24041	171	30	oxidative	oxidative	ADJ
brj-24041	171	31	stress	stress	NOUN
brj-24041	171	32	and	and	CCONJ
brj-24041	171	33	pro	pro	ADJ
brj-24041	171	34	-	-	ADJ
brj-24041	171	35	inflammatory	inflammatory	ADJ
brj-24041	171	36	cytokines	cytokine	NOUN
brj-24041	171	37	in	in	ADP
brj-24041	171	38	the	the	DET
brj-24041	171	39	serum	serum	NOUN
brj-24041	171	40	of	of	ADP
brj-24041	171	41	oa	oa	NOUN
brj-24041	171	42	rats	rat	NOUN
brj-24041	171	43	.	.	PUNCT
brj-24041	172	1	as	as	SCONJ
brj-24041	172	2	shown	show	VERB
brj-24041	172	3	in	in	ADP
brj-24041	172	4	fig	fig	NOUN
brj-24041	172	5	.	.	PUNCT
brj-24041	173	1	5	5	NUM
brj-24041	173	2	,	,	PUNCT
brj-24041	173	3	the	the	DET
brj-24041	173	4	activity	activity	NOUN
brj-24041	173	5	of	of	ADP
brj-24041	173	6	mda	mda	PROPN
brj-24041	173	7	was	be	AUX
brj-24041	173	8	found	find	VERB
brj-24041	173	9	to	to	PART
brj-24041	173	10	be	be	AUX
brj-24041	173	11	increased	increase	VERB
brj-24041	173	12	with	with	ADP
brj-24041	173	13	subsequent	subsequent	ADJ
brj-24041	173	14	reduction	reduction	NOUN
brj-24041	173	15	in	in	ADP
brj-24041	173	16	gsh	gsh	PROPN
brj-24041	173	17	and	and	CCONJ
brj-24041	173	18	sod	sod	NOUN
brj-24041	173	19	levels	level	NOUN
brj-24041	173	20	in	in	ADP
brj-24041	173	21	comparison	comparison	NOUN
brj-24041	173	22	to	to	ADP
brj-24041	173	23	the	the	DET
brj-24041	173	24	control	control	NOUN
brj-24041	173	25	.	.	PUNCT
brj-24041	174	1	however	however	ADV
brj-24041	174	2	,	,	PUNCT
brj-24041	174	3	after	after	ADP
brj-24041	174	4	administration	administration	NOUN
brj-24041	174	5	of	of	ADP
brj-24041	174	6	aqde	aqde	ADV
brj-24041	174	7	,	,	PUNCT
brj-24041	174	8	the	the	DET
brj-24041	174	9	activities	activity	NOUN
brj-24041	174	10	of	of	ADP
brj-24041	174	11	this	this	DET
brj-24041	174	12	oxidative	oxidative	ADJ
brj-24041	174	13	stress	stress	NOUN
brj-24041	174	14	biomarkers	biomarker	NOUN
brj-24041	174	15	were	be	AUX
brj-24041	174	16	found	find	VERB
brj-24041	174	17	to	to	PART
brj-24041	174	18	be	be	AUX
brj-24041	174	19	restored	restore	VERB
brj-24041	174	20	near	near	ADV
brj-24041	174	21	to	to	ADP
brj-24041	174	22	normal	normal	ADJ
brj-24041	174	23	in	in	ADP
brj-24041	174	24	a	a	DET
brj-24041	174	25	dose	dose	NOUN
brj-24041	174	26	-	-	PUNCT
brj-24041	174	27	dependent	dependent	ADJ
brj-24041	174	28	manner	manner	NOUN
brj-24041	174	29	.	.	PUNCT
brj-24041	175	1	figure	figure	NOUN
brj-24041	175	2	6	6	NUM
brj-24041	175	3	shows	show	VERB
brj-24041	175	4	the	the	DET
brj-24041	175	5	effect	effect	NOUN
brj-24041	175	6	of	of	ADP
brj-24041	175	7	aqde	aqde	ADV
brj-24041	175	8	on	on	ADP
brj-24041	175	9	the	the	DET
brj-24041	175	10	proinflammatory	proinflammatory	ADJ
brj-24041	175	11	cytokines	cytokine	NOUN
brj-24041	175	12	,	,	PUNCT
brj-24041	175	13	such	such	ADJ
brj-24041	175	14	as	as	ADP
brj-24041	175	15	,	,	PUNCT
brj-24041	175	16	il-1β	il-1β	PROPN
brj-24041	175	17	and	and	CCONJ
brj-24041	175	18	il-6	il-6	NOUN
brj-24041	175	19	.	.	PUNCT
brj-24041	176	1	the	the	DET
brj-24041	176	2	concentration	concentration	NOUN
brj-24041	176	3	of	of	ADP
brj-24041	176	4	both	both	CCONJ
brj-24041	176	5	il-1β	il-1β	PROPN
brj-24041	176	6	and	and	CCONJ
brj-24041	176	7	il-6	il-6	NOUN
brj-24041	176	8	was	be	AUX
brj-24041	176	9	significantly	significantly	ADV
brj-24041	176	10	increased	increase	VERB
brj-24041	176	11	in	in	ADP
brj-24041	176	12	oa	oa	PROPN
brj-24041	176	13	group	group	NOUN
brj-24041	176	14	in	in	ADP
brj-24041	176	15	comparison	comparison	NOUN
brj-24041	176	16	to	to	ADP
brj-24041	176	17	the	the	DET
brj-24041	176	18	control	control	NOUN
brj-24041	176	19	.	.	PUNCT
brj-24041	177	1	however	however	ADV
brj-24041	177	2	,	,	PUNCT
brj-24041	177	3	after	after	ADP
brj-24041	177	4	administration	administration	NOUN
brj-24041	177	5	of	of	ADP
brj-24041	177	6	aqde	aqde	ADV
brj-24041	177	7	,	,	PUNCT
brj-24041	177	8	the	the	DET
brj-24041	177	9	concentration	concentration	NOUN
brj-24041	177	10	of	of	ADP
brj-24041	177	11	both	both	DET
brj-24041	177	12	the	the	DET
brj-24041	177	13	tested	test	VERB
brj-24041	177	14	cytokines	cytokine	NOUN
brj-24041	177	15	was	be	AUX
brj-24041	177	16	significantly	significantly	ADV
brj-24041	177	17	reduced	reduce	VERB
brj-24041	177	18	in	in	ADP
brj-24041	177	19	a	a	DET
brj-24041	177	20	dose	dose	NOUN
brj-24041	177	21	-	-	PUNCT
brj-24041	177	22	dependent	dependent	ADJ
brj-24041	177	23	manner	manner	NOUN
brj-24041	177	24	.	.	PUNCT
brj-24041	178	1	the	the	DET
brj-24041	178	2	most	most	ADV
brj-24041	178	3	significant	significant	ADJ
brj-24041	178	4	inhibitory	inhibitory	ADJ
brj-24041	178	5	activity	activity	NOUN
brj-24041	178	6	was	be	AUX
brj-24041	178	7	reported	report	VERB
brj-24041	178	8	in	in	ADP
brj-24041	178	9	the	the	DET
brj-24041	178	10	case	case	NOUN
brj-24041	178	11	of	of	ADP
brj-24041	178	12	50	50	NUM
brj-24041	178	13	mg	mg	NUM
brj-24041	178	14	/	/	SYM
brj-24041	178	15	kg	kg	PROPN
brj-24041	178	16	treated	treat	VERB
brj-24041	178	17	group	group	NOUN
brj-24041	178	18	in	in	ADP
brj-24041	178	19	comparison	comparison	NOUN
brj-24041	178	20	to	to	ADP
brj-24041	178	21	oa	oa	PROPN
brj-24041	178	22	group	group	NOUN
brj-24041	178	23	.	.	PUNCT
brj-24041	179	1	the	the	DET
brj-24041	179	2	results	result	NOUN
brj-24041	179	3	suggested	suggest	VERB
brj-24041	179	4	that	that	SCONJ
brj-24041	179	5	aqde	aqde	ADV
brj-24041	179	6	significantly	significantly	ADV
brj-24041	179	7	diminishes	diminish	VERB
brj-24041	179	8	oxidative	oxidative	ADJ
brj-24041	179	9	stress	stress	NOUN
brj-24041	179	10	and	and	CCONJ
brj-24041	179	11	inflammation	inflammation	NOUN
brj-24041	179	12	in	in	ADP
brj-24041	179	13	mia	mia	PROPN
brj-24041	179	14	rats	rat	NOUN
brj-24041	179	15	.	.	PUNCT
brj-24041	180	1	fig	fig	NOUN
brj-24041	180	2	.	.	PUNCT
brj-24041	181	1	5	5	X
brj-24041	181	2	.	.	X
brj-24041	181	3	effect	effect	NOUN
brj-24041	181	4	of	of	ADP
brj-24041	181	5	aqde	aqde	ADV
brj-24041	181	6	on	on	ADP
brj-24041	181	7	the	the	DET
brj-24041	181	8	a	a	NOUN
brj-24041	181	9	)	)	PUNCT
brj-24041	181	10	mda	mda	PROPN
brj-24041	181	11	,	,	PUNCT
brj-24041	181	12	b	b	X
brj-24041	181	13	)	)	PUNCT
brj-24041	181	14	gsh	gsh	NOUN
brj-24041	181	15	and	and	CCONJ
brj-24041	181	16	sod	sod	NOUN
brj-24041	181	17	.	.	PUNCT
brj-24041	182	1	#	#	NOUN
brj-24041	182	2	p<0.05	p<0.05	NOUN
brj-24041	182	3	vs.	vs.	ADP
brj-24041	182	4	control	control	NOUN
brj-24041	182	5	and	and	CCONJ
brj-24041	182	6	*	*	NOUN
brj-24041	182	7	*	*	PUNCT
brj-24041	182	8	p<0.01	p<0.01	ADP
brj-24041	182	9	vs.	vs.	ADP
brj-24041	182	10	oa	oa	PROPN
brj-24041	182	11	group	group	NOUN
brj-24041	182	12	.	.	PUNCT
brj-24041	183	1	data	datum	NOUN
brj-24041	183	2	are	be	AUX
brj-24041	183	3	presented	present	VERB
brj-24041	183	4	as	as	SCONJ
brj-24041	183	5	means	mean	VERB
brj-24041	183	6	±	±	NUM
brj-24041	183	7	sem	sem	PROPN
brj-24041	183	8	.	.	PUNCT
brj-24041	184	1	peer	peer	NOUN
brj-24041	184	2	-	-	PUNCT
brj-24041	184	3	reviewed	review	VERB
brj-24041	184	4	article	article	NOUN
brj-24041	184	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	184	6	wang	wang	PROPN
brj-24041	184	7	et	et	PROPN
brj-24041	184	8	al	al	PROPN
brj-24041	184	9	.	.	PROPN
brj-24041	185	1	(	(	PUNCT
brj-24041	185	2	2025	2025	NUM
brj-24041	185	3	)	)	PUNCT
brj-24041	185	4	.	.	PUNCT
brj-24041	186	1	“	"	PUNCT
brj-24041	186	2	leaf	leaf	NOUN
brj-24041	186	3	extract	extract	VERB
brj-24041	186	4	anti	anti	ADJ
brj-24041	186	5	-	-	ADJ
brj-24041	186	6	inflammation	inflammation	ADJ
brj-24041	186	7	,	,	PUNCT
brj-24041	186	8	”	"	PUNCT
brj-24041	186	9	bioresources	bioresource	NOUN
brj-24041	186	10	20(1	20(1	NUM
brj-24041	186	11	)	)	PUNCT
brj-24041	186	12	,	,	PUNCT
brj-24041	186	13	956	956	NUM
brj-24041	186	14	-	-	SYM
brj-24041	186	15	971	971	NUM
brj-24041	186	16	.	.	PUNCT
brj-24041	187	1	965	965	NUM
brj-24041	187	2	fig	fig	NOUN
brj-24041	187	3	.	.	PUNCT
brj-24041	188	1	6	6	NUM
brj-24041	188	2	.	.	X
brj-24041	188	3	effect	effect	NOUN
brj-24041	188	4	of	of	ADP
brj-24041	188	5	aqde	aqde	ADV
brj-24041	188	6	on	on	ADP
brj-24041	188	7	a	a	DET
brj-24041	188	8	)	)	PUNCT
brj-24041	188	9	il-1β	il-1β	PROPN
brj-24041	188	10	,	,	PUNCT
brj-24041	188	11	and	and	CCONJ
brj-24041	188	12	b	b	X
brj-24041	188	13	)	)	PUNCT
brj-24041	188	14	il-6	il-6	NOUN
brj-24041	188	15	.	.	PUNCT
brj-24041	189	1	#	#	NOUN
brj-24041	189	2	p<0.05	p<0.05	NOUN
brj-24041	189	3	vs.	vs.	ADP
brj-24041	189	4	control	control	NOUN
brj-24041	189	5	and	and	CCONJ
brj-24041	189	6	*	*	NOUN
brj-24041	189	7	*	*	PUNCT
brj-24041	189	8	p<0.01	p<0.01	ADP
brj-24041	189	9	vs.	vs.	ADP
brj-24041	189	10	oa	oa	PROPN
brj-24041	189	11	group	group	NOUN
brj-24041	189	12	.	.	PUNCT
brj-24041	190	1	data	datum	NOUN
brj-24041	190	2	are	be	AUX
brj-24041	190	3	presented	present	VERB
brj-24041	190	4	as	as	SCONJ
brj-24041	190	5	means	mean	VERB
brj-24041	190	6	±	±	NUM
brj-24041	190	7	sem	sem	PROPN
brj-24041	190	8	.	.	PUNCT
brj-24041	191	1	effect	effect	NOUN
brj-24041	191	2	on	on	ADP
brj-24041	191	3	mrna	mrna	PROPN
brj-24041	191	4	expression	expression	NOUN
brj-24041	191	5	of	of	ADP
brj-24041	191	6	cox2	cox2	NOUN
brj-24041	191	7	,	,	PUNCT
brj-24041	191	8	and	and	CCONJ
brj-24041	191	9	nf	nf	X
brj-24041	191	10	-	-	PUNCT
brj-24041	191	11	κb	κb	NOUN
brj-24041	191	12	in	in	ADP
brj-24041	191	13	cartilage	cartilage	NOUN
brj-24041	191	14	considering	consider	VERB
brj-24041	191	15	the	the	DET
brj-24041	191	16	significant	significant	ADJ
brj-24041	191	17	anti	anti	ADJ
brj-24041	191	18	-	-	ADJ
brj-24041	191	19	inflammatory	inflammatory	ADJ
brj-24041	191	20	effect	effect	NOUN
brj-24041	191	21	of	of	ADP
brj-24041	191	22	aqde	aqde	NOUN
brj-24041	191	23	,	,	PUNCT
brj-24041	191	24	in	in	ADP
brj-24041	191	25	the	the	DET
brj-24041	191	26	next	next	ADJ
brj-24041	191	27	part	part	NOUN
brj-24041	191	28	of	of	ADP
brj-24041	191	29	the	the	DET
brj-24041	191	30	study	study	NOUN
brj-24041	191	31	,	,	PUNCT
brj-24041	191	32	its	its	PRON
brj-24041	191	33	effect	effect	NOUN
brj-24041	191	34	on	on	ADP
brj-24041	191	35	the	the	DET
brj-24041	191	36	mrna	mrna	NOUN
brj-24041	191	37	expression	expression	NOUN
brj-24041	191	38	of	of	ADP
brj-24041	191	39	cox-2	cox-2	NUM
brj-24041	191	40	and	and	CCONJ
brj-24041	191	41	nf	nf	NOUN
brj-24041	191	42	-	-	PUNCT
brj-24041	191	43	κb	κb	PROPN
brj-24041	191	44	was	be	AUX
brj-24041	191	45	examined	examine	VERB
brj-24041	191	46	.	.	PUNCT
brj-24041	192	1	as	as	SCONJ
brj-24041	192	2	shown	show	VERB
brj-24041	192	3	in	in	ADP
brj-24041	192	4	fig	fig	NOUN
brj-24041	192	5	.	.	PUNCT
brj-24041	193	1	7	7	NUM
brj-24041	193	2	,	,	PUNCT
brj-24041	193	3	mia	mia	PROPN
brj-24041	193	4	rats	rat	NOUN
brj-24041	193	5	showed	show	VERB
brj-24041	193	6	increased	increase	VERB
brj-24041	193	7	expression	expression	NOUN
brj-24041	193	8	of	of	ADP
brj-24041	193	9	cox-2	cox-2	NUM
brj-24041	193	10	and	and	CCONJ
brj-24041	193	11	nf	nf	NOUN
brj-24041	193	12	-	-	PUNCT
brj-24041	193	13	κb	κb	NOUN
brj-24041	193	14	in	in	ADP
brj-24041	193	15	comparison	comparison	NOUN
brj-24041	193	16	to	to	ADP
brj-24041	193	17	control	control	VERB
brj-24041	193	18	.	.	PUNCT
brj-24041	194	1	moreover	moreover	ADV
brj-24041	194	2	,	,	PUNCT
brj-24041	194	3	after	after	ADP
brj-24041	194	4	the	the	DET
brj-24041	194	5	administration	administration	NOUN
brj-24041	194	6	of	of	ADP
brj-24041	194	7	aqde	aqde	ADV
brj-24041	194	8	,	,	PUNCT
brj-24041	194	9	the	the	DET
brj-24041	194	10	expression	expression	NOUN
brj-24041	194	11	of	of	ADP
brj-24041	194	12	these	these	DET
brj-24041	194	13	biomarkers	biomarker	NOUN
brj-24041	194	14	was	be	AUX
brj-24041	194	15	found	find	VERB
brj-24041	194	16	reduced	reduce	VERB
brj-24041	194	17	significantly	significantly	ADV
brj-24041	194	18	in	in	ADP
brj-24041	194	19	a	a	DET
brj-24041	194	20	dose	dose	NOUN
brj-24041	194	21	-	-	PUNCT
brj-24041	194	22	dependent	dependent	ADJ
brj-24041	194	23	manner	manner	NOUN
brj-24041	194	24	.	.	PUNCT
brj-24041	195	1	results	result	NOUN
brj-24041	195	2	suggest	suggest	VERB
brj-24041	195	3	that	that	SCONJ
brj-24041	195	4	aqde	aqde	ADV
brj-24041	195	5	significantly	significantly	ADV
brj-24041	195	6	attenuated	attenuate	VERB
brj-24041	195	7	the	the	DET
brj-24041	195	8	inflammation	inflammation	NOUN
brj-24041	195	9	probably	probably	ADV
brj-24041	195	10	by	by	ADP
brj-24041	195	11	inhibiting	inhibit	VERB
brj-24041	195	12	the	the	DET
brj-24041	195	13	cox-2	cox-2	ADJ
brj-24041	195	14	and	and	CCONJ
brj-24041	195	15	nf	nf	NOUN
brj-24041	195	16	-	-	PUNCT
brj-24041	195	17	κb	κb	PROPN
brj-24041	195	18	.	.	PUNCT
brj-24041	195	19	fig	fig	NOUN
brj-24041	195	20	.	.	PUNCT
brj-24041	196	1	7	7	X
brj-24041	196	2	.	.	X
brj-24041	196	3	effect	effect	NOUN
brj-24041	196	4	of	of	ADP
brj-24041	196	5	aqde	aqde	ADV
brj-24041	196	6	on	on	ADP
brj-24041	196	7	a	a	PRON
brj-24041	196	8	)	)	PUNCT
brj-24041	196	9	cox-2	cox-2	NOUN
brj-24041	196	10	and	and	CCONJ
brj-24041	196	11	b	b	NOUN
brj-24041	196	12	)	)	PUNCT
brj-24041	196	13	nf	nf	NOUN
brj-24041	196	14	-	-	PUNCT
brj-24041	196	15	κb	κb	NOUN
brj-24041	196	16	using	use	VERB
brj-24041	196	17	qrt	qrt	ADJ
brj-24041	196	18	-	-	PUNCT
brj-24041	196	19	pcr	pcr	ADJ
brj-24041	196	20	analysis	analysis	NOUN
brj-24041	196	21	.	.	PUNCT
brj-24041	197	1	#	#	ADJ
brj-24041	197	2	p<0.05	p<0.05	NOUN
brj-24041	197	3	vs.	vs.	ADP
brj-24041	197	4	control	control	NOUN
brj-24041	197	5	and	and	CCONJ
brj-24041	197	6	*	*	NOUN
brj-24041	197	7	*	*	PUNCT
brj-24041	197	8	p<0.01	p<0.01	ADP
brj-24041	197	9	vs.	vs.	ADP
brj-24041	197	10	oa	oa	PROPN
brj-24041	197	11	group	group	NOUN
brj-24041	197	12	.	.	PUNCT
brj-24041	198	1	data	datum	NOUN
brj-24041	198	2	are	be	AUX
brj-24041	198	3	presented	present	VERB
brj-24041	198	4	as	as	SCONJ
brj-24041	198	5	means	mean	VERB
brj-24041	198	6	±	±	NUM
brj-24041	198	7	sem	sem	NOUN
brj-24041	198	8	.	.	PUNCT
brj-24041	199	1	osteoarthritis	osteoarthritis	NOUN
brj-24041	199	2	(	(	PUNCT
brj-24041	199	3	oa	oa	X
brj-24041	199	4	)	)	PUNCT
brj-24041	199	5	is	be	AUX
brj-24041	199	6	a	a	DET
brj-24041	199	7	significant	significant	ADJ
brj-24041	199	8	public	public	ADJ
brj-24041	199	9	health	health	NOUN
brj-24041	199	10	concern	concern	NOUN
brj-24041	199	11	,	,	PUNCT
brj-24041	199	12	particularly	particularly	ADV
brj-24041	199	13	among	among	ADP
brj-24041	199	14	the	the	DET
brj-24041	199	15	elderly	elderly	ADJ
brj-24041	199	16	population	population	NOUN
brj-24041	199	17	worldwide	worldwide	ADV
brj-24041	199	18	.	.	PUNCT
brj-24041	200	1	as	as	SCONJ
brj-24041	200	2	life	life	NOUN
brj-24041	200	3	expectancy	expectancy	NOUN
brj-24041	200	4	increases	increase	NOUN
brj-24041	200	5	,	,	PUNCT
brj-24041	200	6	the	the	DET
brj-24041	200	7	prevalence	prevalence	NOUN
brj-24041	200	8	of	of	ADP
brj-24041	200	9	oa	oa	PROPN
brj-24041	200	10	has	have	AUX
brj-24041	200	11	risen	rise	VERB
brj-24041	200	12	,	,	PUNCT
brj-24041	200	13	placing	place	VERB
brj-24041	200	14	an	an	DET
brj-24041	200	15	immense	immense	ADJ
brj-24041	200	16	burden	burden	NOUN
brj-24041	200	17	on	on	ADP
brj-24041	200	18	healthcare	healthcare	NOUN
brj-24041	200	19	systems	system	NOUN
brj-24041	200	20	(	(	PUNCT
brj-24041	200	21	steinmetz	steinmetz	PROPN
brj-24041	200	22	et	et	PROPN
brj-24041	200	23	al	al	PROPN
brj-24041	200	24	.	.	PROPN
brj-24041	200	25	2023	2023	NUM
brj-24041	200	26	)	)	PUNCT
brj-24041	200	27	.	.	PUNCT
brj-24041	201	1	a	a	DET
brj-24041	201	2	substantial	substantial	ADJ
brj-24041	201	3	portion	portion	NOUN
brj-24041	201	4	of	of	ADP
brj-24041	201	5	healthcare	healthcare	NOUN
brj-24041	201	6	expenditures	expenditure	NOUN
brj-24041	201	7	is	be	AUX
brj-24041	201	8	allocated	allocate	VERB
brj-24041	201	9	to	to	ADP
brj-24041	201	10	managing	manage	VERB
brj-24041	201	11	oa	oa	ADV
brj-24041	201	12	-	-	PUNCT
brj-24041	201	13	related	relate	VERB
brj-24041	201	14	peer	peer	NOUN
brj-24041	201	15	-	-	PUNCT
brj-24041	201	16	reviewed	review	VERB
brj-24041	201	17	article	article	NOUN
brj-24041	201	18	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	201	19	wang	wang	PROPN
brj-24041	201	20	et	et	PROPN
brj-24041	201	21	al	al	PROPN
brj-24041	201	22	.	.	PROPN
brj-24041	202	1	(	(	PUNCT
brj-24041	202	2	2025	2025	NUM
brj-24041	202	3	)	)	PUNCT
brj-24041	202	4	.	.	PUNCT
brj-24041	203	1	“	"	PUNCT
brj-24041	203	2	leaf	leaf	NOUN
brj-24041	203	3	extract	extract	VERB
brj-24041	203	4	anti	anti	ADJ
brj-24041	203	5	-	-	ADJ
brj-24041	203	6	inflammation	inflammation	ADJ
brj-24041	203	7	,	,	PUNCT
brj-24041	203	8	”	"	PUNCT
brj-24041	203	9	bioresources	bioresource	NOUN
brj-24041	203	10	20(1	20(1	NUM
brj-24041	203	11	)	)	PUNCT
brj-24041	203	12	,	,	PUNCT
brj-24041	203	13	956	956	NUM
brj-24041	203	14	-	-	SYM
brj-24041	203	15	971	971	NUM
brj-24041	203	16	.	.	PUNCT
brj-24041	204	1	966	966	NUM
brj-24041	204	2	complications	complication	NOUN
brj-24041	204	3	,	,	PUNCT
brj-24041	204	4	which	which	PRON
brj-24041	204	5	include	include	VERB
brj-24041	204	6	chronic	chronic	ADJ
brj-24041	204	7	pain	pain	NOUN
brj-24041	204	8	,	,	PUNCT
brj-24041	204	9	reduced	reduce	VERB
brj-24041	204	10	mobility	mobility	NOUN
brj-24041	204	11	,	,	PUNCT
brj-24041	204	12	and	and	CCONJ
brj-24041	204	13	diminished	diminish	VERB
brj-24041	204	14	quality	quality	NOUN
brj-24041	204	15	of	of	ADP
brj-24041	204	16	life	life	NOUN
brj-24041	204	17	.	.	PUNCT
brj-24041	205	1	this	this	DET
brj-24041	205	2	condition	condition	NOUN
brj-24041	205	3	not	not	PART
brj-24041	205	4	only	only	ADV
brj-24041	205	5	affects	affect	VERB
brj-24041	205	6	the	the	DET
brj-24041	205	7	physical	physical	ADJ
brj-24041	205	8	well	well	NOUN
brj-24041	205	9	-	-	PUNCT
brj-24041	205	10	being	being	NOUN
brj-24041	205	11	of	of	ADP
brj-24041	205	12	individuals	individual	NOUN
brj-24041	205	13	but	but	CCONJ
brj-24041	205	14	also	also	ADV
brj-24041	205	15	imposes	impose	VERB
brj-24041	205	16	economic	economic	ADJ
brj-24041	205	17	and	and	CCONJ
brj-24041	205	18	social	social	ADJ
brj-24041	205	19	challenges	challenge	NOUN
brj-24041	205	20	.	.	PUNCT
brj-24041	206	1	with	with	ADP
brj-24041	206	2	the	the	DET
brj-24041	206	3	elderly	elderly	ADJ
brj-24041	206	4	population	population	NOUN
brj-24041	206	5	projected	project	VERB
brj-24041	206	6	to	to	PART
brj-24041	206	7	grow	grow	VERB
brj-24041	206	8	further	far	ADV
brj-24041	206	9	,	,	PUNCT
brj-24041	206	10	the	the	DET
brj-24041	206	11	demand	demand	NOUN
brj-24041	206	12	for	for	ADP
brj-24041	206	13	effective	effective	ADJ
brj-24041	206	14	treatments	treatment	NOUN
brj-24041	206	15	and	and	CCONJ
brj-24041	206	16	preventive	preventive	ADJ
brj-24041	206	17	strategies	strategy	NOUN
brj-24041	206	18	is	be	AUX
brj-24041	206	19	becoming	become	VERB
brj-24041	206	20	increasingly	increasingly	ADV
brj-24041	206	21	urgent	urgent	ADJ
brj-24041	206	22	to	to	PART
brj-24041	206	23	mitigate	mitigate	VERB
brj-24041	206	24	the	the	DET
brj-24041	206	25	healthcare	healthcare	NOUN
brj-24041	206	26	costs	cost	NOUN
brj-24041	206	27	associated	associate	VERB
brj-24041	206	28	with	with	ADP
brj-24041	206	29	oa	oa	PROPN
brj-24041	206	30	(	(	PUNCT
brj-24041	206	31	mobasheri	mobasheri	NOUN
brj-24041	206	32	and	and	CCONJ
brj-24041	206	33	batt	batt	NOUN
brj-24041	206	34	2016	2016	NUM
brj-24041	206	35	;	;	PUNCT
brj-24041	206	36	aubourg	aubourg	PROPN
brj-24041	206	37	et	et	PROPN
brj-24041	206	38	al	al	PROPN
brj-24041	206	39	.	.	PROPN
brj-24041	206	40	2022	2022	NUM
brj-24041	206	41	)	)	PUNCT
brj-24041	206	42	.	.	PUNCT
brj-24041	207	1	herbal	herbal	ADJ
brj-24041	207	2	extracts	extract	NOUN
brj-24041	207	3	offer	offer	VERB
brj-24041	207	4	significant	significant	ADJ
brj-24041	207	5	benefits	benefit	NOUN
brj-24041	207	6	in	in	ADP
brj-24041	207	7	the	the	DET
brj-24041	207	8	prevention	prevention	NOUN
brj-24041	207	9	and	and	CCONJ
brj-24041	207	10	management	management	NOUN
brj-24041	207	11	of	of	ADP
brj-24041	207	12	osteoarthritis	osteoarthritis	NOUN
brj-24041	207	13	(	(	PUNCT
brj-24041	207	14	oa	oa	PROPN
brj-24041	207	15	)	)	PUNCT
brj-24041	207	16	due	due	ADP
brj-24041	207	17	to	to	ADP
brj-24041	207	18	their	their	PRON
brj-24041	207	19	natural	natural	ADJ
brj-24041	207	20	anti	anti	ADJ
brj-24041	207	21	-	-	ADJ
brj-24041	207	22	inflammatory	inflammatory	ADJ
brj-24041	207	23	and	and	CCONJ
brj-24041	207	24	antioxidant	antioxidant	ADJ
brj-24041	207	25	properties	property	NOUN
brj-24041	207	26	.	.	PUNCT
brj-24041	208	1	key	key	ADJ
brj-24041	208	2	advantages	advantage	NOUN
brj-24041	208	3	include	include	VERB
brj-24041	208	4	reducing	reduce	VERB
brj-24041	208	5	inflammation	inflammation	NOUN
brj-24041	208	6	,	,	PUNCT
brj-24041	208	7	protecting	protect	VERB
brj-24041	208	8	cartilage	cartilage	NOUN
brj-24041	208	9	,	,	PUNCT
brj-24041	208	10	and	and	CCONJ
brj-24041	208	11	neutralizing	neutralize	VERB
brj-24041	208	12	oxidative	oxidative	ADJ
brj-24041	208	13	stress	stress	NOUN
brj-24041	208	14	,	,	PUNCT
brj-24041	208	15	which	which	PRON
brj-24041	208	16	contribute	contribute	VERB
brj-24041	208	17	to	to	ADP
brj-24041	208	18	joint	joint	ADJ
brj-24041	208	19	damage	damage	NOUN
brj-24041	208	20	.	.	PUNCT
brj-24041	209	1	unlike	unlike	ADP
brj-24041	209	2	conventional	conventional	ADJ
brj-24041	209	3	nsaids	nsaid	NOUN
brj-24041	209	4	,	,	PUNCT
brj-24041	209	5	herbal	herbal	ADJ
brj-24041	209	6	remedies	remedy	NOUN
brj-24041	209	7	such	such	ADJ
brj-24041	209	8	as	as	ADP
brj-24041	209	9	turmeric	turmeric	ADJ
brj-24041	209	10	,	,	PUNCT
brj-24041	209	11	ginger	ginger	NOUN
brj-24041	209	12	,	,	PUNCT
brj-24041	209	13	and	and	CCONJ
brj-24041	209	14	boswellia	boswellia	PROPN
brj-24041	209	15	typically	typically	ADV
brj-24041	209	16	have	have	VERB
brj-24041	209	17	fewer	few	ADJ
brj-24041	209	18	side	side	NOUN
brj-24041	209	19	effects	effect	NOUN
brj-24041	209	20	,	,	PUNCT
brj-24041	209	21	making	make	VERB
brj-24041	209	22	them	they	PRON
brj-24041	209	23	safer	safe	ADJ
brj-24041	209	24	for	for	ADP
brj-24041	209	25	long	long	ADJ
brj-24041	209	26	-	-	PUNCT
brj-24041	209	27	term	term	NOUN
brj-24041	209	28	use	use	NOUN
brj-24041	209	29	.	.	PUNCT
brj-24041	210	1	they	they	PRON
brj-24041	210	2	also	also	ADV
brj-24041	210	3	provide	provide	VERB
brj-24041	210	4	a	a	DET
brj-24041	210	5	cost	cost	NOUN
brj-24041	210	6	-	-	PUNCT
brj-24041	210	7	effective	effective	ADJ
brj-24041	210	8	alternative	alternative	NOUN
brj-24041	210	9	,	,	PUNCT
brj-24041	210	10	accessible	accessible	ADJ
brj-24041	210	11	to	to	ADP
brj-24041	210	12	many	many	ADJ
brj-24041	210	13	.	.	PUNCT
brj-24041	211	1	when	when	SCONJ
brj-24041	211	2	used	use	VERB
brj-24041	211	3	alongside	alongside	ADP
brj-24041	211	4	lifestyle	lifestyle	NOUN
brj-24041	211	5	interventions	intervention	NOUN
brj-24041	211	6	like	like	ADP
brj-24041	211	7	exercise	exercise	NOUN
brj-24041	211	8	and	and	CCONJ
brj-24041	211	9	weight	weight	NOUN
brj-24041	211	10	management	management	NOUN
brj-24041	211	11	,	,	PUNCT
brj-24041	211	12	herbal	herbal	ADJ
brj-24041	211	13	extracts	extract	NOUN
brj-24041	211	14	offer	offer	VERB
brj-24041	211	15	a	a	DET
brj-24041	211	16	holistic	holistic	ADJ
brj-24041	211	17	approach	approach	NOUN
brj-24041	211	18	to	to	ADP
brj-24041	211	19	managing	manage	VERB
brj-24041	211	20	oa	oa	PRON
brj-24041	211	21	and	and	CCONJ
brj-24041	211	22	improving	improve	VERB
brj-24041	211	23	overall	overall	ADJ
brj-24041	211	24	joint	joint	ADJ
brj-24041	211	25	health	health	NOUN
brj-24041	211	26	(	(	PUNCT
brj-24041	211	27	verma	verma	PROPN
brj-24041	211	28	2023	2023	NUM
brj-24041	211	29	)	)	PUNCT
brj-24041	211	30	.	.	PUNCT
brj-24041	212	1	the	the	DET
brj-24041	212	2	present	present	ADJ
brj-24041	212	3	study	study	NOUN
brj-24041	212	4	showed	show	VERB
brj-24041	212	5	the	the	DET
brj-24041	212	6	beneficial	beneficial	ADJ
brj-24041	212	7	effect	effect	NOUN
brj-24041	212	8	of	of	ADP
brj-24041	212	9	akebia	akebia	PROPN
brj-24041	212	10	quinata	quinata	VERB
brj-24041	212	11	d.	d.	PROPN
brj-24041	212	12	aqueous	aqueous	PROPN
brj-24041	212	13	extract	extract	NOUN
brj-24041	212	14	(	(	PUNCT
brj-24041	212	15	aqde	aqde	ADV
brj-24041	212	16	)	)	PUNCT
brj-24041	212	17	against	against	ADP
brj-24041	212	18	osteoarthritis	osteoarthritis	NOUN
brj-24041	212	19	.	.	PUNCT
brj-24041	213	1	the	the	DET
brj-24041	213	2	extract	extract	NOUN
brj-24041	213	3	showed	show	VERB
brj-24041	213	4	significant	significant	ADJ
brj-24041	213	5	ameliorative	ameliorative	ADJ
brj-24041	213	6	effect	effect	NOUN
brj-24041	213	7	against	against	ADP
brj-24041	213	8	various	various	ADJ
brj-24041	213	9	biochemical	biochemical	ADJ
brj-24041	213	10	pathways	pathway	NOUN
brj-24041	213	11	known	know	VERB
brj-24041	213	12	to	to	PART
brj-24041	213	13	promote	promote	VERB
brj-24041	213	14	oa	oa	INTJ
brj-24041	213	15	,	,	PUNCT
brj-24041	213	16	such	such	ADJ
brj-24041	213	17	as	as	ADP
brj-24041	213	18	oxidative	oxidative	ADJ
brj-24041	213	19	stress	stress	NOUN
brj-24041	213	20	,	,	PUNCT
brj-24041	213	21	inflammation	inflammation	NOUN
brj-24041	213	22	,	,	PUNCT
brj-24041	213	23	and	and	CCONJ
brj-24041	213	24	helps	help	VERB
brj-24041	213	25	to	to	PART
brj-24041	213	26	improve	improve	VERB
brj-24041	213	27	the	the	DET
brj-24041	213	28	cartilage	cartilage	NOUN
brj-24041	213	29	density	density	NOUN
brj-24041	213	30	and	and	CCONJ
brj-24041	213	31	bone	bone	NOUN
brj-24041	213	32	erosion	erosion	NOUN
brj-24041	213	33	.	.	PUNCT
brj-24041	214	1	accumulating	accumulate	VERB
brj-24041	214	2	evidence	evidence	NOUN
brj-24041	214	3	has	have	AUX
brj-24041	214	4	suggested	suggest	VERB
brj-24041	214	5	that	that	SCONJ
brj-24041	214	6	oa	oa	PROPN
brj-24041	214	7	entails	entail	VERB
brj-24041	214	8	the	the	DET
brj-24041	214	9	gradual	gradual	ADJ
brj-24041	214	10	deterioration	deterioration	NOUN
brj-24041	214	11	of	of	ADP
brj-24041	214	12	cartilage	cartilage	NOUN
brj-24041	214	13	and	and	CCONJ
brj-24041	214	14	persistent	persistent	ADJ
brj-24041	214	15	joint	joint	ADJ
brj-24041	214	16	inflammation	inflammation	NOUN
brj-24041	214	17	,	,	PUNCT
brj-24041	214	18	influenced	influence	VERB
brj-24041	214	19	by	by	ADP
brj-24041	214	20	critical	critical	ADJ
brj-24041	214	21	molecular	molecular	ADJ
brj-24041	214	22	markers	marker	NOUN
brj-24041	214	23	including	include	VERB
brj-24041	214	24	acgan	acgan	VERB
brj-24041	214	25	,	,	PUNCT
brj-24041	214	26	col2a	col2a	PROPN
brj-24041	214	27	,	,	PUNCT
brj-24041	214	28	il-1β	il-1β	PROPN
brj-24041	214	29	,	,	PUNCT
brj-24041	214	30	il-6	il-6	PRON
brj-24041	214	31	,	,	PUNCT
brj-24041	214	32	mmp13	mmp13	NOUN
brj-24041	214	33	,	,	PUNCT
brj-24041	214	34	and	and	CCONJ
brj-24041	214	35	ptgs2	ptgs2	PROPN
brj-24041	214	36	(	(	PUNCT
brj-24041	214	37	mobasheri	mobasheri	NOUN
brj-24041	214	38	and	and	CCONJ
brj-24041	214	39	batt	batt	PROPN
brj-24041	214	40	2016	2016	NUM
brj-24041	214	41	;	;	PUNCT
brj-24041	214	42	sun	sun	PROPN
brj-24041	214	43	et	et	PROPN
brj-24041	214	44	al	al	PROPN
brj-24041	214	45	.	.	PROPN
brj-24041	214	46	2019a	2019a	NUM
brj-24041	214	47	)	)	PUNCT
brj-24041	214	48	.	.	PUNCT
brj-24041	215	1	aggrecan	aggrecan	PROPN
brj-24041	215	2	(	(	PUNCT
brj-24041	215	3	acgan	acgan	ADJ
brj-24041	215	4	)	)	PUNCT
brj-24041	215	5	,	,	PUNCT
brj-24041	215	6	an	an	DET
brj-24041	215	7	essential	essential	ADJ
brj-24041	215	8	cartilage	cartilage	NOUN
brj-24041	215	9	matrix	matrix	NOUN
brj-24041	215	10	protein	protein	NOUN
brj-24041	215	11	,	,	PUNCT
brj-24041	215	12	preserves	preserve	VERB
brj-24041	215	13	cartilage	cartilage	NOUN
brj-24041	215	14	architecture	architecture	NOUN
brj-24041	215	15	and	and	CCONJ
brj-24041	215	16	functionality	functionality	NOUN
brj-24041	215	17	.	.	PUNCT
brj-24041	216	1	the	the	DET
brj-24041	216	2	degradation	degradation	NOUN
brj-24041	216	3	of	of	ADP
brj-24041	216	4	cartilage	cartilage	NOUN
brj-24041	216	5	in	in	ADP
brj-24041	216	6	osteoarthritis	osteoarthritis	NOUN
brj-24041	216	7	(	(	PUNCT
brj-24041	216	8	oa	oa	INTJ
brj-24041	216	9	)	)	PUNCT
brj-24041	216	10	by	by	ADP
brj-24041	216	11	matrix	matrix	NOUN
brj-24041	216	12	metalloproteinases	metalloproteinase	NOUN
brj-24041	216	13	(	(	PUNCT
brj-24041	216	14	mmps	mmp	NOUN
brj-24041	216	15	)	)	PUNCT
brj-24041	216	16	renders	render	VERB
brj-24041	216	17	it	it	PRON
brj-24041	216	18	a	a	DET
brj-24041	216	19	viable	viable	ADJ
brj-24041	216	20	therapeutic	therapeutic	ADJ
brj-24041	216	21	target	target	NOUN
brj-24041	216	22	for	for	ADP
brj-24041	216	23	the	the	DET
brj-24041	216	24	prevention	prevention	NOUN
brj-24041	216	25	of	of	ADP
brj-24041	216	26	tissue	tissue	NOUN
brj-24041	216	27	loss	loss	NOUN
brj-24041	216	28	.	.	PUNCT
brj-24041	217	1	collagen	collagen	NOUN
brj-24041	217	2	type	type	PROPN
brj-24041	217	3	ii	ii	PROPN
brj-24041	217	4	(	(	PUNCT
brj-24041	217	5	col2a	col2a	PROPN
brj-24041	217	6	)	)	PUNCT
brj-24041	217	7	,	,	PUNCT
brj-24041	217	8	a	a	DET
brj-24041	217	9	major	major	ADJ
brj-24041	217	10	structural	structural	ADJ
brj-24041	217	11	protein	protein	NOUN
brj-24041	217	12	in	in	ADP
brj-24041	217	13	cartilage	cartilage	NOUN
brj-24041	217	14	,	,	PUNCT
brj-24041	217	15	also	also	ADV
brj-24041	217	16	degrades	degrade	VERB
brj-24041	217	17	during	during	ADP
brj-24041	217	18	osteoarthritis	osteoarthritis	NOUN
brj-24041	217	19	(	(	PUNCT
brj-24041	217	20	oa	oa	NOUN
brj-24041	217	21	)	)	PUNCT
brj-24041	217	22	.	.	PUNCT
brj-24041	218	1	decreased	decrease	VERB
brj-24041	218	2	col2a	col2a	DET
brj-24041	218	3	production	production	NOUN
brj-24041	218	4	or	or	CCONJ
brj-24041	218	5	heightened	heighten	VERB
brj-24041	218	6	degradation	degradation	NOUN
brj-24041	218	7	leads	lead	VERB
brj-24041	218	8	to	to	ADP
brj-24041	218	9	joint	joint	ADJ
brj-24041	218	10	impairment	impairment	NOUN
brj-24041	218	11	,	,	PUNCT
brj-24041	218	12	and	and	CCONJ
brj-24041	218	13	interventions	intervention	NOUN
brj-24041	218	14	that	that	PRON
brj-24041	218	15	enhance	enhance	VERB
brj-24041	218	16	collagen	collagen	NOUN
brj-24041	218	17	stability	stability	NOUN
brj-24041	218	18	may	may	AUX
brj-24041	218	19	decelerate	decelerate	VERB
brj-24041	218	20	disease	disease	NOUN
brj-24041	218	21	advancement	advancement	NOUN
brj-24041	218	22	(	(	PUNCT
brj-24041	218	23	zhang	zhang	X
brj-24041	218	24	et	et	PROPN
brj-24041	218	25	al	al	PROPN
brj-24041	218	26	.	.	PROPN
brj-24041	218	27	2023	2023	NUM
brj-24041	218	28	)	)	PUNCT
brj-24041	218	29	.	.	PUNCT
brj-24041	219	1	inflammatory	inflammatory	ADJ
brj-24041	219	2	cytokines	cytokine	NOUN
brj-24041	219	3	,	,	PUNCT
brj-24041	219	4	including	include	VERB
brj-24041	219	5	il-1β	il-1β	PROPN
brj-24041	219	6	and	and	CCONJ
brj-24041	219	7	il-6	il-6	NOUN
brj-24041	219	8	,	,	PUNCT
brj-24041	219	9	are	be	AUX
brj-24041	219	10	significantly	significantly	ADV
brj-24041	219	11	increased	increase	VERB
brj-24041	219	12	in	in	ADP
brj-24041	219	13	osteoarthritis	osteoarthritis	NOUN
brj-24041	219	14	,	,	PUNCT
brj-24041	219	15	promoting	promote	VERB
brj-24041	219	16	inflammation	inflammation	NOUN
brj-24041	219	17	and	and	CCONJ
brj-24041	219	18	cartilage	cartilage	NOUN
brj-24041	219	19	breakdown	breakdown	NOUN
brj-24041	219	20	.	.	PUNCT
brj-24041	220	1	il-1β	il-1β	PROPN
brj-24041	220	2	induces	induce	VERB
brj-24041	220	3	mmp	mmp	PROPN
brj-24041	220	4	expression	expression	NOUN
brj-24041	220	5	,	,	PUNCT
brj-24041	220	6	exacerbating	exacerbate	VERB
brj-24041	220	7	cartilage	cartilage	NOUN
brj-24041	220	8	degradation	degradation	NOUN
brj-24041	220	9	,	,	PUNCT
brj-24041	220	10	whereas	whereas	SCONJ
brj-24041	220	11	il-6	il-6	PRON
brj-24041	220	12	facilitates	facilitate	VERB
brj-24041	220	13	chronic	chronic	ADJ
brj-24041	220	14	inflammation	inflammation	NOUN
brj-24041	220	15	.	.	PUNCT
brj-24041	221	1	cytokine	cytokine	ADJ
brj-24041	221	2	inhibitors	inhibitor	NOUN
brj-24041	221	3	,	,	PUNCT
brj-24041	221	4	including	include	VERB
brj-24041	221	5	il-1β	il-1β	PROPN
brj-24041	221	6	antagonists	antagonist	NOUN
brj-24041	221	7	(	(	PUNCT
brj-24041	221	8	e.g.	e.g.	ADV
brj-24041	221	9	,	,	PUNCT
brj-24041	221	10	anakinra	anakinra	NOUN
brj-24041	221	11	)	)	PUNCT
brj-24041	221	12	and	and	CCONJ
brj-24041	221	13	il-6	il-6	NOUN
brj-24041	221	14	inhibitors	inhibitor	NOUN
brj-24041	221	15	(	(	PUNCT
brj-24041	221	16	e.g.	e.g.	ADV
brj-24041	221	17	,	,	PUNCT
brj-24041	221	18	tocilizumab	tocilizumab	NOUN
brj-24041	221	19	)	)	PUNCT
brj-24041	221	20	,	,	PUNCT
brj-24041	221	21	have	have	AUX
brj-24041	221	22	demonstrated	demonstrate	VERB
brj-24041	221	23	efficacy	efficacy	NOUN
brj-24041	221	24	in	in	ADP
brj-24041	221	25	mitigating	mitigate	VERB
brj-24041	221	26	inflammation	inflammation	NOUN
brj-24041	221	27	and	and	CCONJ
brj-24041	221	28	cartilage	cartilage	NOUN
brj-24041	221	29	degradation	degradation	NOUN
brj-24041	221	30	.	.	PUNCT
brj-24041	222	1	mmp13	mmp13	NOUN
brj-24041	222	2	is	be	AUX
brj-24041	222	3	crucial	crucial	ADJ
brj-24041	222	4	in	in	ADP
brj-24041	222	5	the	the	DET
brj-24041	222	6	degradation	degradation	NOUN
brj-24041	222	7	of	of	ADP
brj-24041	222	8	collagen	collagen	PROPN
brj-24041	222	9	ii	ii	PROPN
brj-24041	222	10	,	,	PUNCT
brj-24041	222	11	expediting	expedite	VERB
brj-24041	222	12	cartilage	cartilage	NOUN
brj-24041	222	13	deterioration	deterioration	NOUN
brj-24041	222	14	in	in	ADP
brj-24041	222	15	osteoarthritis	osteoarthritis	NOUN
brj-24041	222	16	.	.	PUNCT
brj-24041	223	1	it	it	PRON
brj-24041	223	2	follows	follow	VERB
brj-24041	223	3	that	that	SCONJ
brj-24041	223	4	inhibiting	inhibit	VERB
brj-24041	223	5	mmp13	mmp13	NOUN
brj-24041	223	6	may	may	AUX
brj-24041	223	7	safeguard	safeguard	VERB
brj-24041	223	8	against	against	ADP
brj-24041	223	9	more	more	ADJ
brj-24041	223	10	cartilage	cartilage	NOUN
brj-24041	223	11	injury	injury	NOUN
brj-24041	223	12	.	.	PUNCT
brj-24041	224	1	finally	finally	ADV
brj-24041	224	2	,	,	PUNCT
brj-24041	224	3	ptgs2	ptgs2	PROPN
brj-24041	224	4	(	(	PUNCT
brj-24041	224	5	cox-2	cox-2	NOUN
brj-24041	224	6	)	)	PUNCT
brj-24041	224	7	is	be	AUX
brj-24041	224	8	overexpressed	overexpresse	VERB
brj-24041	224	9	in	in	ADP
brj-24041	224	10	osteoarthritis	osteoarthritis	NOUN
brj-24041	224	11	,	,	PUNCT
brj-24041	224	12	augmenting	augment	VERB
brj-24041	224	13	the	the	DET
brj-24041	224	14	synthesis	synthesis	NOUN
brj-24041	224	15	of	of	ADP
brj-24041	224	16	proinflammatory	proinflammatory	ADJ
brj-24041	224	17	prostaglandins	prostaglandin	NOUN
brj-24041	224	18	,	,	PUNCT
brj-24041	224	19	which	which	PRON
brj-24041	224	20	results	result	VERB
brj-24041	224	21	in	in	ADP
brj-24041	224	22	pain	pain	NOUN
brj-24041	224	23	and	and	CCONJ
brj-24041	224	24	inflammation	inflammation	NOUN
brj-24041	224	25	.	.	PUNCT
brj-24041	225	1	cox-2	cox-2	VERB
brj-24041	225	2	inhibitors	inhibitor	NOUN
brj-24041	225	3	,	,	PUNCT
brj-24041	225	4	such	such	ADJ
brj-24041	225	5	as	as	ADP
brj-24041	225	6	celecoxib	celecoxib	NOUN
brj-24041	225	7	,	,	PUNCT
brj-24041	225	8	are	be	AUX
brj-24041	225	9	frequently	frequently	ADV
brj-24041	225	10	employed	employ	VERB
brj-24041	225	11	to	to	PART
brj-24041	225	12	mitigate	mitigate	VERB
brj-24041	225	13	symptoms	symptom	NOUN
brj-24041	225	14	through	through	ADP
brj-24041	225	15	the	the	DET
brj-24041	225	16	reduction	reduction	NOUN
brj-24041	225	17	of	of	ADP
brj-24041	225	18	inflammation	inflammation	NOUN
brj-24041	225	19	.	.	PUNCT
brj-24041	226	1	targeting	target	VERB
brj-24041	226	2	these	these	DET
brj-24041	226	3	molecular	molecular	ADJ
brj-24041	226	4	pathways	pathway	NOUN
brj-24041	226	5	with	with	ADP
brj-24041	226	6	anti	anti	ADJ
brj-24041	226	7	-	-	ADJ
brj-24041	226	8	inflammatory	inflammatory	ADJ
brj-24041	226	9	medications	medication	NOUN
brj-24041	226	10	that	that	PRON
brj-24041	226	11	maintain	maintain	VERB
brj-24041	226	12	cartilage	cartilage	NOUN
brj-24041	226	13	integrity	integrity	NOUN
brj-24041	226	14	presents	present	VERB
brj-24041	226	15	a	a	DET
brj-24041	226	16	viable	viable	ADJ
brj-24041	226	17	approach	approach	NOUN
brj-24041	226	18	for	for	ADP
brj-24041	226	19	decelerating	decelerate	VERB
brj-24041	226	20	or	or	CCONJ
brj-24041	226	21	reversing	reverse	VERB
brj-24041	226	22	the	the	DET
brj-24041	226	23	course	course	NOUN
brj-24041	226	24	of	of	ADP
brj-24041	226	25	osteoarthritis	osteoarthritis	NOUN
brj-24041	226	26	,	,	PUNCT
brj-24041	226	27	as	as	SCONJ
brj-24041	226	28	evidenced	evidence	VERB
brj-24041	226	29	by	by	ADP
brj-24041	226	30	several	several	ADJ
brj-24041	226	31	clinical	clinical	ADJ
brj-24041	226	32	and	and	CCONJ
brj-24041	226	33	preclinical	preclinical	ADJ
brj-24041	226	34	investigations	investigation	NOUN
brj-24041	226	35	(	(	PUNCT
brj-24041	226	36	fan	fan	NOUN
brj-24041	226	37	et	et	PROPN
brj-24041	226	38	al	al	PROPN
brj-24041	226	39	.	.	PROPN
brj-24041	226	40	2015	2015	NUM
brj-24041	226	41	;	;	PUNCT
brj-24041	226	42	lee	lee	PROPN
brj-24041	226	43	et	et	PROPN
brj-24041	226	44	al	al	PROPN
brj-24041	226	45	.	.	PROPN
brj-24041	226	46	2022a	2022a	NUM
brj-24041	226	47	)	)	PUNCT
brj-24041	226	48	.	.	PUNCT
brj-24041	227	1	in	in	ADP
brj-24041	227	2	the	the	DET
brj-24041	227	3	present	present	ADJ
brj-24041	227	4	study	study	NOUN
brj-24041	227	5	,	,	PUNCT
brj-24041	227	6	aqde	aqde	ADV
brj-24041	227	7	was	be	AUX
brj-24041	227	8	found	find	VERB
brj-24041	227	9	to	to	PART
brj-24041	227	10	cause	cause	VERB
brj-24041	227	11	significant	significant	ADJ
brj-24041	227	12	restoration	restoration	NOUN
brj-24041	227	13	of	of	ADP
brj-24041	227	14	these	these	DET
brj-24041	227	15	parameters	parameter	NOUN
brj-24041	227	16	to	to	PART
brj-24041	227	17	near	near	ADV
brj-24041	227	18	to	to	ADP
brj-24041	227	19	normal	normal	ADJ
brj-24041	227	20	.	.	PUNCT
brj-24041	228	1	this	this	PRON
brj-24041	228	2	suggests	suggest	VERB
brj-24041	228	3	that	that	SCONJ
brj-24041	228	4	aqde	aqde	ADV
brj-24041	228	5	stimulate	stimulate	VERB
brj-24041	228	6	the	the	DET
brj-24041	228	7	formation	formation	NOUN
brj-24041	228	8	of	of	ADP
brj-24041	228	9	cartilaginous	cartilaginous	ADJ
brj-24041	228	10	extracellular	extracellular	ADJ
brj-24041	228	11	matrix	matrix	NOUN
brj-24041	228	12	(	(	PUNCT
brj-24041	228	13	ecm	ecm	NOUN
brj-24041	228	14	)	)	PUNCT
brj-24041	228	15	synthesis	synthesis	NOUN
brj-24041	228	16	and	and	CCONJ
brj-24041	228	17	the	the	DET
brj-24041	228	18	reduction	reduction	NOUN
brj-24041	228	19	of	of	ADP
brj-24041	228	20	the	the	DET
brj-24041	228	21	expression	expression	NOUN
brj-24041	228	22	of	of	ADP
brj-24041	228	23	inflammatory	inflammatory	ADJ
brj-24041	228	24	genes	gene	NOUN
brj-24041	228	25	that	that	PRON
brj-24041	228	26	is	be	AUX
brj-24041	228	27	caused	cause	VERB
brj-24041	228	28	by	by	ADP
brj-24041	228	29	tnf	tnf	PROPN
brj-24041	228	30	-	-	PUNCT
brj-24041	228	31	α	α	PROPN
brj-24041	228	32	.	.	PUNCT
brj-24041	229	1	degeneration	degeneration	NOUN
brj-24041	229	2	of	of	ADP
brj-24041	229	3	cartilage	cartilage	NOUN
brj-24041	229	4	and	and	CCONJ
brj-24041	229	5	chondrocyte	chondrocyte	NOUN
brj-24041	229	6	death	death	NOUN
brj-24041	229	7	are	be	AUX
brj-24041	229	8	caused	cause	VERB
brj-24041	229	9	by	by	ADP
brj-24041	229	10	apoptosis	apoptosis	NOUN
brj-24041	229	11	and	and	CCONJ
brj-24041	229	12	dysregulation	dysregulation	NOUN
brj-24041	229	13	of	of	ADP
brj-24041	229	14	cell	cell	NOUN
brj-24041	229	15	cycle	cycle	NOUN
brj-24041	229	16	proteins	protein	NOUN
brj-24041	229	17	in	in	ADP
brj-24041	229	18	osteoarthritis	osteoarthritis	NOUN
brj-24041	229	19	(	(	PUNCT
brj-24041	229	20	oa	oa	NOUN
brj-24041	229	21	)	)	PUNCT
brj-24041	229	22	.	.	PUNCT
brj-24041	230	1	these	these	DET
brj-24041	230	2	pathways	pathway	NOUN
brj-24041	230	3	involve	involve	VERB
brj-24041	230	4	bcl-2	bcl-2	NOUN
brj-24041	230	5	,	,	PUNCT
brj-24041	230	6	cdk1	cdk1	PROPN
brj-24041	230	7	,	,	PUNCT
brj-24041	230	8	cyclin	cyclin	PROPN
brj-24041	230	9	d	d	PROPN
brj-24041	230	10	(	(	PUNCT
brj-24041	230	11	ccnd	ccnd	PROPN
brj-24041	230	12	)	)	PUNCT
brj-24041	230	13	,	,	PUNCT
brj-24041	230	14	and	and	CCONJ
brj-24041	230	15	apoptosis	apoptosis	NOUN
brj-24041	230	16	(	(	PUNCT
brj-24041	230	17	musumeci	musumeci	PROPN
brj-24041	230	18	et	et	PROPN
brj-24041	230	19	al	al	PROPN
brj-24041	230	20	.	.	PROPN
brj-24041	230	21	2015	2015	NUM
brj-24041	230	22	;	;	PUNCT
brj-24041	230	23	tan	tan	PROPN
brj-24041	230	24	et	et	PROPN
brj-24041	230	25	al	al	PROPN
brj-24041	230	26	.	.	PROPN
brj-24041	230	27	2019	2019	NUM
brj-24041	230	28	)	)	PUNCT
brj-24041	230	29	.	.	PUNCT
brj-24041	231	1	by	by	ADP
brj-24041	231	2	blocking	block	VERB
brj-24041	231	3	mitochondrial	mitochondrial	ADJ
brj-24041	231	4	-	-	PUNCT
brj-24041	231	5	mediated	mediate	VERB
brj-24041	231	6	apoptosis	apoptosis	NOUN
brj-24041	231	7	,	,	PUNCT
brj-24041	231	8	the	the	DET
brj-24041	231	9	anti	anti	ADJ
brj-24041	231	10	-	-	ADJ
brj-24041	231	11	apoptotic	apoptotic	ADJ
brj-24041	231	12	protein	protein	NOUN
brj-24041	231	13	bcl-2	bcl-2	PUNCT
brj-24041	231	14	aids	aid	NOUN
brj-24041	231	15	in	in	ADP
brj-24041	231	16	peer	peer	NOUN
brj-24041	231	17	-	-	PUNCT
brj-24041	231	18	reviewed	review	VERB
brj-24041	231	19	article	article	NOUN
brj-24041	231	20	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	231	21	wang	wang	PROPN
brj-24041	231	22	et	et	PROPN
brj-24041	231	23	al	al	PROPN
brj-24041	231	24	.	.	PROPN
brj-24041	232	1	(	(	PUNCT
brj-24041	232	2	2025	2025	NUM
brj-24041	232	3	)	)	PUNCT
brj-24041	232	4	.	.	PUNCT
brj-24041	233	1	“	"	PUNCT
brj-24041	233	2	leaf	leaf	NOUN
brj-24041	233	3	extract	extract	VERB
brj-24041	233	4	anti	anti	ADJ
brj-24041	233	5	-	-	ADJ
brj-24041	233	6	inflammation	inflammation	ADJ
brj-24041	233	7	,	,	PUNCT
brj-24041	233	8	”	"	PUNCT
brj-24041	233	9	bioresources	bioresource	NOUN
brj-24041	233	10	20(1	20(1	NUM
brj-24041	233	11	)	)	PUNCT
brj-24041	233	12	,	,	PUNCT
brj-24041	233	13	956	956	NUM
brj-24041	233	14	-	-	SYM
brj-24041	233	15	971	971	NUM
brj-24041	233	16	.	.	PUNCT
brj-24041	234	1	967	967	NUM
brj-24041	234	2	controlling	control	VERB
brj-24041	234	3	cell	cell	NOUN
brj-24041	234	4	survival	survival	NOUN
brj-24041	234	5	.	.	PUNCT
brj-24041	235	1	accelerated	accelerate	VERB
brj-24041	235	2	cartilage	cartilage	NOUN
brj-24041	235	3	degradation	degradation	NOUN
brj-24041	235	4	is	be	AUX
brj-24041	235	5	caused	cause	VERB
brj-24041	235	6	by	by	ADP
brj-24041	235	7	downregulation	downregulation	NOUN
brj-24041	235	8	of	of	ADP
brj-24041	235	9	bcl-2	bcl-2	NOUN
brj-24041	235	10	in	in	ADP
brj-24041	235	11	oa	oa	NOUN
brj-24041	235	12	,	,	PUNCT
brj-24041	235	13	which	which	PRON
brj-24041	235	14	in	in	ADP
brj-24041	235	15	turn	turn	NOUN
brj-24041	235	16	increases	increase	VERB
brj-24041	235	17	chondrocyte	chondrocyte	PROPN
brj-24041	235	18	death	death	NOUN
brj-24041	235	19	.	.	PUNCT
brj-24041	236	1	preventing	prevent	VERB
brj-24041	236	2	chondrocyte	chondrocyte	NOUN
brj-24041	236	3	mortality	mortality	NOUN
brj-24041	236	4	and	and	CCONJ
brj-24041	236	5	slowing	slow	VERB
brj-24041	236	6	the	the	DET
brj-24041	236	7	course	course	NOUN
brj-24041	236	8	of	of	ADP
brj-24041	236	9	oa	oa	PRON
brj-24041	236	10	may	may	AUX
brj-24041	236	11	be	be	AUX
brj-24041	236	12	possible	possible	ADJ
brj-24041	236	13	by	by	ADP
brj-24041	236	14	targeting	target	VERB
brj-24041	236	15	bcl-2	bcl-2	NOUN
brj-24041	236	16	pathways	pathway	NOUN
brj-24041	236	17	to	to	PART
brj-24041	236	18	boost	boost	VERB
brj-24041	236	19	its	its	PRON
brj-24041	236	20	expression	expression	NOUN
brj-24041	236	21	.	.	PUNCT
brj-24041	237	1	the	the	DET
brj-24041	237	2	appropriate	appropriate	ADJ
brj-24041	237	3	proliferation	proliferation	NOUN
brj-24041	237	4	and	and	CCONJ
brj-24041	237	5	repair	repair	NOUN
brj-24041	237	6	of	of	ADP
brj-24041	237	7	chondrocytes	chondrocyte	NOUN
brj-24041	237	8	are	be	AUX
brj-24041	237	9	ensured	ensure	VERB
brj-24041	237	10	by	by	ADP
brj-24041	237	11	the	the	DET
brj-24041	237	12	cell	cell	NOUN
brj-24041	237	13	cycle	cycle	NOUN
brj-24041	237	14	regulators	regulator	NOUN
brj-24041	237	15	cyclin	cyclin	PROPN
brj-24041	237	16	d	d	PROPN
brj-24041	237	17	(	(	PUNCT
brj-24041	237	18	ccnd	ccnd	PROPN
brj-24041	237	19	)	)	PUNCT
brj-24041	237	20	and	and	CCONJ
brj-24041	237	21	cdk1	cdk1	PROPN
brj-24041	237	22	(	(	PUNCT
brj-24041	237	23	saito	saito	PROPN
brj-24041	237	24	et	et	PROPN
brj-24041	237	25	al	al	PROPN
brj-24041	237	26	.	.	PROPN
brj-24041	237	27	2016	2016	NUM
brj-24041	237	28	;	;	PUNCT
brj-24041	237	29	kihara	kihara	PROPN
brj-24041	237	30	et	et	PROPN
brj-24041	237	31	al	al	PROPN
brj-24041	237	32	.	.	PROPN
brj-24041	237	33	2017	2017	NUM
brj-24041	237	34	)	)	PUNCT
brj-24041	237	35	.	.	PUNCT
brj-24041	238	1	cartilage	cartilage	NOUN
brj-24041	238	2	regeneration	regeneration	NOUN
brj-24041	238	3	is	be	AUX
brj-24041	238	4	hindered	hinder	VERB
brj-24041	238	5	and	and	CCONJ
brj-24041	238	6	chondrocyte	chondrocyte	NOUN
brj-24041	238	7	proliferation	proliferation	NOUN
brj-24041	238	8	is	be	AUX
brj-24041	238	9	diminished	diminish	VERB
brj-24041	238	10	in	in	ADP
brj-24041	238	11	oa	oa	PRON
brj-24041	238	12	due	due	ADP
brj-24041	238	13	to	to	ADP
brj-24041	238	14	cell	cell	NOUN
brj-24041	238	15	cycle	cycle	NOUN
brj-24041	238	16	arrest	arrest	NOUN
brj-24041	238	17	caused	cause	VERB
brj-24041	238	18	by	by	ADP
brj-24041	238	19	abnormalities	abnormality	NOUN
brj-24041	238	20	in	in	ADP
brj-24041	238	21	the	the	DET
brj-24041	238	22	cyclin	cyclin	NOUN
brj-24041	238	23	d	d	PROPN
brj-24041	238	24	-	-	PUNCT
brj-24041	238	25	cdk1	cdk1	PROPN
brj-24041	238	26	complex	complex	NOUN
brj-24041	238	27	.	.	PUNCT
brj-24041	239	1	enhancing	enhance	VERB
brj-24041	239	2	chondrocyte	chondrocyte	NOUN
brj-24041	239	3	activity	activity	NOUN
brj-24041	239	4	and	and	CCONJ
brj-24041	239	5	supporting	support	VERB
brj-24041	239	6	cartilage	cartilage	NOUN
brj-24041	239	7	regeneration	regeneration	NOUN
brj-24041	239	8	by	by	ADP
brj-24041	239	9	restoring	restore	VERB
brj-24041	239	10	the	the	DET
brj-24041	239	11	function	function	NOUN
brj-24041	239	12	of	of	ADP
brj-24041	239	13	these	these	DET
brj-24041	239	14	cell	cell	NOUN
brj-24041	239	15	cycle	cycle	NOUN
brj-24041	239	16	regulators	regulator	NOUN
brj-24041	239	17	offers	offer	VERB
brj-24041	239	18	a	a	DET
brj-24041	239	19	viable	viable	ADJ
brj-24041	239	20	therapeutic	therapeutic	ADJ
brj-24041	239	21	option	option	NOUN
brj-24041	239	22	.	.	PUNCT
brj-24041	240	1	the	the	DET
brj-24041	240	2	planned	plan	VERB
brj-24041	240	3	cell	cell	NOUN
brj-24041	240	4	death	death	NOUN
brj-24041	240	5	mechanism	mechanism	NOUN
brj-24041	240	6	,	,	PUNCT
brj-24041	240	7	known	know	VERB
brj-24041	240	8	as	as	ADP
brj-24041	240	9	apoptosis	apoptosis	NOUN
brj-24041	240	10	,	,	PUNCT
brj-24041	240	11	is	be	AUX
brj-24041	240	12	dramatically	dramatically	ADV
brj-24041	240	13	increased	increase	VERB
brj-24041	240	14	in	in	ADP
brj-24041	240	15	oa	oa	ADP
brj-24041	240	16	,	,	PUNCT
brj-24041	240	17	which	which	PRON
brj-24041	240	18	leads	lead	VERB
brj-24041	240	19	to	to	ADP
brj-24041	240	20	a	a	DET
brj-24041	240	21	decrease	decrease	NOUN
brj-24041	240	22	in	in	ADP
brj-24041	240	23	chondrocytes	chondrocyte	NOUN
brj-24041	240	24	(	(	PUNCT
brj-24041	240	25	musumeci	musumeci	PROPN
brj-24041	240	26	et	et	PROPN
brj-24041	240	27	al	al	PROPN
brj-24041	240	28	.	.	PROPN
brj-24041	240	29	2015	2015	NUM
brj-24041	240	30	)	)	PUNCT
brj-24041	240	31	.	.	PUNCT
brj-24041	241	1	when	when	SCONJ
brj-24041	241	2	cells	cell	NOUN
brj-24041	241	3	are	be	AUX
brj-24041	241	4	subjected	subject	VERB
brj-24041	241	5	to	to	ADP
brj-24041	241	6	mechanical	mechanical	ADJ
brj-24041	241	7	stress	stress	NOUN
brj-24041	241	8	or	or	CCONJ
brj-24041	241	9	inflammatory	inflammatory	ADJ
brj-24041	241	10	cytokines	cytokine	NOUN
brj-24041	241	11	,	,	PUNCT
brj-24041	241	12	they	they	PRON
brj-24041	241	13	trigger	trigger	VERB
brj-24041	241	14	apoptosis	apoptosis	NOUN
brj-24041	241	15	through	through	ADP
brj-24041	241	16	both	both	CCONJ
brj-24041	241	17	intrinsic	intrinsic	ADJ
brj-24041	241	18	(	(	PUNCT
brj-24041	241	19	mitochondrial	mitochondrial	ADJ
brj-24041	241	20	)	)	PUNCT
brj-24041	241	21	and	and	CCONJ
brj-24041	241	22	extrinsic	extrinsic	ADJ
brj-24041	241	23	(	(	PUNCT
brj-24041	241	24	non	non	ADJ
brj-24041	241	25	-	-	ADJ
brj-24041	241	26	mitochondrial	mitochondrial	ADJ
brj-24041	241	27	)	)	PUNCT
brj-24041	241	28	routes	route	NOUN
brj-24041	241	29	.	.	PUNCT
brj-24041	242	1	potentially	potentially	ADV
brj-24041	242	2	useful	useful	ADJ
brj-24041	242	3	drugs	drug	NOUN
brj-24041	242	4	for	for	ADP
brj-24041	242	5	reducing	reduce	VERB
brj-24041	242	6	chondrocyte	chondrocyte	NOUN
brj-24041	242	7	loss	loss	NOUN
brj-24041	242	8	and	and	CCONJ
brj-24041	242	9	preserving	preserve	VERB
brj-24041	242	10	cartilage	cartilage	NOUN
brj-24041	242	11	include	include	VERB
brj-24041	242	12	medicines	medicine	NOUN
brj-24041	242	13	that	that	PRON
brj-24041	242	14	enhance	enhance	VERB
brj-24041	242	15	anti	anti	ADJ
brj-24041	242	16	-	-	ADJ
brj-24041	242	17	apoptotic	apoptotic	ADJ
brj-24041	242	18	proteins	protein	NOUN
brj-24041	242	19	such	such	ADJ
brj-24041	242	20	as	as	ADP
brj-24041	242	21	bcl-2	bcl-2	NOUN
brj-24041	242	22	or	or	CCONJ
brj-24041	242	23	inhibitors	inhibitor	NOUN
brj-24041	242	24	of	of	ADP
brj-24041	242	25	pro	pro	ADJ
brj-24041	242	26	-	-	ADJ
brj-24041	242	27	apoptotic	apoptotic	ADJ
brj-24041	242	28	factors	factor	NOUN
brj-24041	242	29	.	.	PUNCT
brj-24041	243	1	various	various	ADJ
brj-24041	243	2	preclinical	preclinical	ADJ
brj-24041	243	3	and	and	CCONJ
brj-24041	243	4	clinical	clinical	ADJ
brj-24041	243	5	investigations	investigation	NOUN
brj-24041	243	6	have	have	AUX
brj-24041	243	7	demonstrated	demonstrate	VERB
brj-24041	243	8	that	that	SCONJ
brj-24041	243	9	medicines	medicine	NOUN
brj-24041	243	10	that	that	PRON
brj-24041	243	11	modulate	modulate	VERB
brj-24041	243	12	bcl-2	bcl-2	NOUN
brj-24041	243	13	,	,	PUNCT
brj-24041	243	14	cdk1	cdk1	PROPN
brj-24041	243	15	,	,	PUNCT
brj-24041	243	16	ccnd	ccnd	NOUN
brj-24041	243	17	,	,	PUNCT
brj-24041	243	18	and	and	CCONJ
brj-24041	243	19	apoptosis	apoptosis	NOUN
brj-24041	243	20	can	can	AUX
brj-24041	243	21	protect	protect	VERB
brj-24041	243	22	cartilage	cartilage	NOUN
brj-24041	243	23	,	,	PUNCT
brj-24041	243	24	halt	halt	VERB
brj-24041	243	25	further	further	ADJ
brj-24041	243	26	deterioration	deterioration	NOUN
brj-24041	243	27	,	,	PUNCT
brj-24041	243	28	and	and	CCONJ
brj-24041	243	29	improve	improve	VERB
brj-24041	243	30	joint	joint	ADJ
brj-24041	243	31	health	health	NOUN
brj-24041	243	32	.	.	PUNCT
brj-24041	244	1	in	in	ADP
brj-24041	244	2	the	the	DET
brj-24041	244	3	present	present	ADJ
brj-24041	244	4	study	study	NOUN
brj-24041	244	5	,	,	PUNCT
brj-24041	244	6	aqde	aqde	ADV
brj-24041	244	7	was	be	AUX
brj-24041	244	8	found	find	VERB
brj-24041	244	9	to	to	PART
brj-24041	244	10	cause	cause	VERB
brj-24041	244	11	significant	significant	ADJ
brj-24041	244	12	modulation	modulation	NOUN
brj-24041	244	13	of	of	ADP
brj-24041	244	14	these	these	DET
brj-24041	244	15	biomarkers	biomarker	NOUN
brj-24041	244	16	near	near	ADV
brj-24041	244	17	to	to	ADP
brj-24041	244	18	normal	normal	ADJ
brj-24041	244	19	and	and	CCONJ
brj-24041	244	20	halted	halt	VERB
brj-24041	244	21	the	the	DET
brj-24041	244	22	process	process	NOUN
brj-24041	244	23	apoptosis	apoptosis	NOUN
brj-24041	244	24	of	of	ADP
brj-24041	244	25	rat	rat	NOUN
brj-24041	244	26	chondrocytes	chondrocyte	NOUN
brj-24041	244	27	.	.	PUNCT
brj-24041	245	1	mechanical	mechanical	ADJ
brj-24041	245	2	allodynia	allodynia	PROPN
brj-24041	245	3	,	,	PUNCT
brj-24041	245	4	assessed	assess	VERB
brj-24041	245	5	using	use	VERB
brj-24041	245	6	the	the	DET
brj-24041	245	7	von	von	PROPN
brj-24041	245	8	frey	frey	PROPN
brj-24041	245	9	test	test	NOUN
brj-24041	245	10	,	,	PUNCT
brj-24041	245	11	and	and	CCONJ
brj-24041	245	12	knee	knee	NOUN
brj-24041	245	13	joint	joint	ADJ
brj-24041	245	14	swelling	swelling	NOUN
brj-24041	245	15	are	be	AUX
brj-24041	245	16	critical	critical	ADJ
brj-24041	245	17	measures	measure	NOUN
brj-24041	245	18	in	in	ADP
brj-24041	245	19	evaluating	evaluate	VERB
brj-24041	245	20	the	the	DET
brj-24041	245	21	pharmacological	pharmacological	ADJ
brj-24041	245	22	effects	effect	NOUN
brj-24041	245	23	of	of	ADP
brj-24041	245	24	drugs	drug	NOUN
brj-24041	245	25	against	against	ADP
brj-24041	245	26	osteoarthritis	osteoarthritis	NOUN
brj-24041	245	27	(	(	PUNCT
brj-24041	245	28	oa	oa	PROPN
brj-24041	245	29	)	)	PUNCT
brj-24041	245	30	(	(	PUNCT
brj-24041	245	31	eitner	eitner	NOUN
brj-24041	245	32	et	et	PROPN
brj-24041	245	33	al	al	PROPN
brj-24041	245	34	.	.	PROPN
brj-24041	245	35	2020	2020	NUM
brj-24041	245	36	;	;	PUNCT
brj-24041	245	37	rizk	rizk	PROPN
brj-24041	245	38	et	et	PROPN
brj-24041	245	39	al	al	PROPN
brj-24041	245	40	.	.	PROPN
brj-24041	245	41	2023	2023	NUM
brj-24041	245	42	)	)	PUNCT
brj-24041	245	43	.	.	PUNCT
brj-24041	246	1	the	the	DET
brj-24041	246	2	von	von	PROPN
brj-24041	246	3	frey	frey	PROPN
brj-24041	246	4	test	test	NOUN
brj-24041	246	5	measures	measure	NOUN
brj-24041	246	6	sensitivity	sensitivity	NOUN
brj-24041	246	7	to	to	AUX
brj-24041	246	8	normally	normally	ADV
brj-24041	246	9	non	non	ADJ
brj-24041	246	10	-	-	ADJ
brj-24041	246	11	painful	painful	ADJ
brj-24041	246	12	stimuli	stimulus	NOUN
brj-24041	246	13	,	,	PUNCT
brj-24041	246	14	indicating	indicate	VERB
brj-24041	246	15	the	the	DET
brj-24041	246	16	drug	drug	NOUN
brj-24041	246	17	’s	’s	PART
brj-24041	246	18	impact	impact	NOUN
brj-24041	246	19	on	on	ADP
brj-24041	246	20	oa	oa	ADV
brj-24041	246	21	-	-	PUNCT
brj-24041	246	22	induced	induced	ADJ
brj-24041	246	23	pain	pain	NOUN
brj-24041	246	24	,	,	PUNCT
brj-24041	246	25	a	a	DET
brj-24041	246	26	major	major	ADJ
brj-24041	246	27	symptom	symptom	NOUN
brj-24041	246	28	.	.	PUNCT
brj-24041	247	1	in	in	ADP
brj-24041	247	2	this	this	PRON
brj-24041	247	3	,	,	PUNCT
brj-24041	247	4	a	a	DET
brj-24041	247	5	series	series	NOUN
brj-24041	247	6	of	of	ADP
brj-24041	247	7	filaments	filament	NOUN
brj-24041	247	8	with	with	ADP
brj-24041	247	9	increasing	increase	VERB
brj-24041	247	10	or	or	CCONJ
brj-24041	247	11	decreasing	decrease	VERB
brj-24041	247	12	forces	force	NOUN
brj-24041	247	13	are	be	AUX
brj-24041	247	14	applied	apply	VERB
brj-24041	247	15	in	in	ADP
brj-24041	247	16	sequence	sequence	NOUN
brj-24041	247	17	to	to	PART
brj-24041	247	18	determine	determine	VERB
brj-24041	247	19	the	the	DET
brj-24041	247	20	mechanical	mechanical	ADJ
brj-24041	247	21	threshold	threshold	NOUN
brj-24041	247	22	,	,	PUNCT
brj-24041	247	23	the	the	DET
brj-24041	247	24	minimum	minimum	ADJ
brj-24041	247	25	force	force	NOUN
brj-24041	247	26	required	require	VERB
brj-24041	247	27	to	to	PART
brj-24041	247	28	elicit	elicit	VERB
brj-24041	247	29	a	a	DET
brj-24041	247	30	response	response	NOUN
brj-24041	247	31	.	.	PUNCT
brj-24041	248	1	the	the	DET
brj-24041	248	2	animal	animal	NOUN
brj-24041	248	3	’s	’s	PART
brj-24041	248	4	behavioural	behavioural	ADJ
brj-24041	248	5	response	response	NOUN
brj-24041	248	6	,	,	PUNCT
brj-24041	248	7	such	such	ADJ
brj-24041	248	8	as	as	ADP
brj-24041	248	9	paw	paw	PROPN
brj-24041	248	10	withdrawal	withdrawal	NOUN
brj-24041	248	11	,	,	PUNCT
brj-24041	248	12	flinching	flinching	NOUN
brj-24041	248	13	,	,	PUNCT
brj-24041	248	14	or	or	CCONJ
brj-24041	248	15	licking	lick	VERB
brj-24041	248	16	,	,	PUNCT
brj-24041	248	17	indicates	indicate	VERB
brj-24041	248	18	that	that	SCONJ
brj-24041	248	19	the	the	DET
brj-24041	248	20	sensation	sensation	NOUN
brj-24041	248	21	of	of	ADP
brj-24041	248	22	pain	pain	NOUN
brj-24041	248	23	or	or	CCONJ
brj-24041	248	24	discomfort	discomfort	NOUN
brj-24041	248	25	was	be	AUX
brj-24041	248	26	recorded	record	VERB
brj-24041	248	27	.	.	PUNCT
brj-24041	249	1	based	base	VERB
brj-24041	249	2	on	on	ADP
brj-24041	249	3	these	these	DET
brj-24041	249	4	results	result	NOUN
brj-24041	249	5	,	,	PUNCT
brj-24041	249	6	lower	low	ADJ
brj-24041	249	7	thresholds	threshold	NOUN
brj-24041	249	8	indicate	indicate	VERB
brj-24041	249	9	increased	increase	VERB
brj-24041	249	10	sensitivity	sensitivity	NOUN
brj-24041	249	11	(	(	PUNCT
brj-24041	249	12	hyperalgesia	hyperalgesia	NOUN
brj-24041	249	13	or	or	CCONJ
brj-24041	249	14	allodynia	allodynia	ADJ
brj-24041	249	15	)	)	PUNCT
brj-24041	249	16	.	.	PUNCT
brj-24041	250	1	higher	high	ADJ
brj-24041	250	2	thresholds	threshold	NOUN
brj-24041	250	3	indicate	indicate	VERB
brj-24041	250	4	reduced	reduce	VERB
brj-24041	250	5	sensitivity	sensitivity	NOUN
brj-24041	250	6	(	(	PUNCT
brj-24041	250	7	hypoalgesia	hypoalgesia	NOUN
brj-24041	250	8	or	or	CCONJ
brj-24041	250	9	analgesia	analgesia	PROPN
brj-24041	250	10	)	)	PUNCT
brj-24041	250	11	,	,	PUNCT
brj-24041	250	12	and	and	CCONJ
brj-24041	250	13	reduction	reduction	NOUN
brj-24041	250	14	in	in	ADP
brj-24041	250	15	mechanical	mechanical	ADJ
brj-24041	250	16	allodynia	allodynia	NOUN
brj-24041	250	17	reflects	reflect	VERB
brj-24041	250	18	effective	effective	ADJ
brj-24041	250	19	pain	pain	NOUN
brj-24041	250	20	relief	relief	NOUN
brj-24041	250	21	.	.	PUNCT
brj-24041	251	1	in	in	ADP
brj-24041	251	2	the	the	DET
brj-24041	251	3	present	present	ADJ
brj-24041	251	4	study	study	NOUN
brj-24041	251	5	,	,	PUNCT
brj-24041	251	6	the	the	DET
brj-24041	251	7	significant	significant	ADJ
brj-24041	251	8	improvement	improvement	NOUN
brj-24041	251	9	in	in	ADP
brj-24041	251	10	the	the	DET
brj-24041	251	11	withdrawal	withdrawal	NOUN
brj-24041	251	12	threshold	threshold	NOUN
brj-24041	251	13	by	by	ADP
brj-24041	251	14	the	the	DET
brj-24041	251	15	aqde	aqde	ADJ
brj-24041	251	16	suggest	suggest	VERB
brj-24041	251	17	that	that	SCONJ
brj-24041	251	18	it	it	PRON
brj-24041	251	19	significantly	significantly	ADV
brj-24041	251	20	improves	improve	VERB
brj-24041	251	21	the	the	DET
brj-24041	251	22	sensitivity	sensitivity	NOUN
brj-24041	251	23	of	of	ADP
brj-24041	251	24	rats	rat	NOUN
brj-24041	251	25	against	against	ADP
brj-24041	251	26	the	the	DET
brj-24041	251	27	non	non	ADJ
brj-24041	251	28	-	-	ADJ
brj-24041	251	29	pain	pain	ADJ
brj-24041	251	30	stimuli	stimulus	NOUN
brj-24041	251	31	,	,	PUNCT
brj-24041	251	32	and	and	CCONJ
brj-24041	251	33	thus	thus	ADV
brj-24041	251	34	may	may	AUX
brj-24041	251	35	be	be	AUX
brj-24041	251	36	effective	effective	ADJ
brj-24041	251	37	against	against	ADP
brj-24041	251	38	oa	oa	INTJ
brj-24041	251	39	.	.	PUNCT
brj-24041	251	40	knee	knee	NOUN
brj-24041	251	41	joint	joint	ADJ
brj-24041	251	42	swelling	swelling	NOUN
brj-24041	251	43	,	,	PUNCT
brj-24041	251	44	a	a	DET
brj-24041	251	45	marker	marker	NOUN
brj-24041	251	46	of	of	ADP
brj-24041	251	47	inflammation	inflammation	NOUN
brj-24041	251	48	and	and	CCONJ
brj-24041	251	49	joint	joint	ADJ
brj-24041	251	50	damage	damage	NOUN
brj-24041	251	51	,	,	PUNCT
brj-24041	251	52	assesses	assess	VERB
brj-24041	251	53	the	the	DET
brj-24041	251	54	drug	drug	NOUN
brj-24041	251	55	's	's	PART
brj-24041	251	56	anti	anti	ADJ
brj-24041	251	57	-	-	ADJ
brj-24041	251	58	inflammatory	inflammatory	ADJ
brj-24041	251	59	properties	property	NOUN
brj-24041	251	60	.	.	PUNCT
brj-24041	252	1	a	a	DET
brj-24041	252	2	decrease	decrease	NOUN
brj-24041	252	3	in	in	ADP
brj-24041	252	4	swelling	swell	VERB
brj-24041	252	5	in	in	ADP
brj-24041	252	6	aqde	aqde	ADV
brj-24041	252	7	in	in	ADP
brj-24041	252	8	the	the	DET
brj-24041	252	9	present	present	ADJ
brj-24041	252	10	study	study	NOUN
brj-24041	252	11	indicates	indicate	VERB
brj-24041	252	12	reduced	reduced	ADJ
brj-24041	252	13	inflammation	inflammation	NOUN
brj-24041	252	14	and	and	CCONJ
brj-24041	252	15	joint	joint	ADJ
brj-24041	252	16	degradation	degradation	NOUN
brj-24041	252	17	.	.	PUNCT
brj-24041	253	1	together	together	ADV
brj-24041	253	2	,	,	PUNCT
brj-24041	253	3	improvement	improvement	NOUN
brj-24041	253	4	of	of	ADP
brj-24041	253	5	these	these	DET
brj-24041	253	6	tests	test	NOUN
brj-24041	253	7	provides	provide	VERB
brj-24041	253	8	valuable	valuable	ADJ
brj-24041	253	9	insights	insight	NOUN
brj-24041	253	10	into	into	ADP
brj-24041	253	11	an	an	DET
brj-24041	253	12	efficacy	efficacy	NOUN
brj-24041	253	13	of	of	ADP
brj-24041	253	14	aqde	aqde	ADV
brj-24041	253	15	in	in	ADP
brj-24041	253	16	reducing	reduce	VERB
brj-24041	253	17	pain	pain	NOUN
brj-24041	253	18	and	and	CCONJ
brj-24041	253	19	inflammation	inflammation	NOUN
brj-24041	253	20	in	in	ADP
brj-24041	253	21	oa	oa	PROPN
brj-24041	253	22	models	model	NOUN
brj-24041	253	23	.	.	PUNCT
brj-24041	254	1	oxidative	oxidative	ADJ
brj-24041	254	2	stress	stress	NOUN
brj-24041	254	3	and	and	CCONJ
brj-24041	254	4	inflammation	inflammation	NOUN
brj-24041	254	5	play	play	VERB
brj-24041	254	6	pivotal	pivotal	ADJ
brj-24041	254	7	roles	role	NOUN
brj-24041	254	8	in	in	ADP
brj-24041	254	9	the	the	DET
brj-24041	254	10	pathogenesis	pathogenesis	NOUN
brj-24041	254	11	of	of	ADP
brj-24041	254	12	osteoarthritis	osteoarthritis	NOUN
brj-24041	254	13	(	(	PUNCT
brj-24041	254	14	oa	oa	NOUN
brj-24041	254	15	)	)	PUNCT
brj-24041	254	16	.	.	PUNCT
brj-24041	255	1	oxidative	oxidative	ADJ
brj-24041	255	2	stress	stress	NOUN
brj-24041	255	3	arises	arise	VERB
brj-24041	255	4	from	from	ADP
brj-24041	255	5	the	the	DET
brj-24041	255	6	overproduction	overproduction	NOUN
brj-24041	255	7	of	of	ADP
brj-24041	255	8	reactive	reactive	ADJ
brj-24041	255	9	oxygen	oxygen	NOUN
brj-24041	255	10	species	specie	NOUN
brj-24041	255	11	(	(	PUNCT
brj-24041	255	12	ros	ros	PROPN
brj-24041	255	13	)	)	PUNCT
brj-24041	255	14	,	,	PUNCT
brj-24041	255	15	which	which	DET
brj-24041	255	16	damage	damage	NOUN
brj-24041	255	17	cartilage	cartilage	NOUN
brj-24041	255	18	and	and	CCONJ
brj-24041	255	19	joint	joint	ADJ
brj-24041	255	20	tissues	tissue	NOUN
brj-24041	255	21	by	by	ADP
brj-24041	255	22	degrading	degrade	VERB
brj-24041	255	23	collagen	collagen	NOUN
brj-24041	255	24	and	and	CCONJ
brj-24041	255	25	proteoglycans	proteoglycan	NOUN
brj-24041	255	26	(	(	PUNCT
brj-24041	255	27	chatterjee	chatterjee	PROPN
brj-24041	255	28	2016	2016	NUM
brj-24041	255	29	)	)	PUNCT
brj-24041	255	30	.	.	PUNCT
brj-24041	256	1	this	this	DET
brj-24041	256	2	process	process	NOUN
brj-24041	256	3	exacerbates	exacerbate	VERB
brj-24041	256	4	the	the	DET
brj-24041	256	5	inflammatory	inflammatory	ADJ
brj-24041	256	6	response	response	NOUN
brj-24041	256	7	,	,	PUNCT
brj-24041	256	8	leading	lead	VERB
brj-24041	256	9	to	to	ADP
brj-24041	256	10	the	the	DET
brj-24041	256	11	activation	activation	NOUN
brj-24041	256	12	of	of	ADP
brj-24041	256	13	pro	pro	ADJ
brj-24041	256	14	-	-	ADJ
brj-24041	256	15	inflammatory	inflammatory	ADJ
brj-24041	256	16	cytokines	cytokine	NOUN
brj-24041	256	17	including	include	VERB
brj-24041	256	18	il-1β	il-1β	PROPN
brj-24041	256	19	and	and	CCONJ
brj-24041	256	20	tnf	tnf	PROPN
brj-24041	256	21	-	-	PUNCT
brj-24041	256	22	α	α	PROPN
brj-24041	256	23	,	,	PUNCT
brj-24041	256	24	which	which	PRON
brj-24041	256	25	further	far	ADV
brj-24041	256	26	accelerate	accelerate	VERB
brj-24041	256	27	cartilage	cartilage	NOUN
brj-24041	256	28	breakdown	breakdown	NOUN
brj-24041	256	29	and	and	CCONJ
brj-24041	256	30	joint	joint	ADJ
brj-24041	256	31	degeneration	degeneration	NOUN
brj-24041	256	32	(	(	PUNCT
brj-24041	256	33	fernández	fernández	PROPN
brj-24041	256	34	-	-	PUNCT
brj-24041	256	35	sánchez	sánchez	PROPN
brj-24041	256	36	et	et	PROPN
brj-24041	256	37	al	al	PROPN
brj-24041	256	38	.	.	PROPN
brj-24041	256	39	2011	2011	NUM
brj-24041	256	40	)	)	PUNCT
brj-24041	256	41	.	.	PUNCT
brj-24041	257	1	chronic	chronic	ADJ
brj-24041	257	2	inflammation	inflammation	NOUN
brj-24041	257	3	perpetuates	perpetuate	VERB
brj-24041	257	4	the	the	DET
brj-24041	257	5	cycle	cycle	NOUN
brj-24041	257	6	of	of	ADP
brj-24041	257	7	tissue	tissue	NOUN
brj-24041	257	8	damage	damage	NOUN
brj-24041	257	9	,	,	PUNCT
brj-24041	257	10	resulting	result	VERB
brj-24041	257	11	in	in	ADP
brj-24041	257	12	pain	pain	NOUN
brj-24041	257	13	and	and	CCONJ
brj-24041	257	14	joint	joint	ADJ
brj-24041	257	15	dysfunction	dysfunction	NOUN
brj-24041	257	16	in	in	ADP
brj-24041	257	17	oa	oa	ADP
brj-24041	257	18	patients	patient	NOUN
brj-24041	257	19	.	.	PUNCT
brj-24041	258	1	drugs	drug	NOUN
brj-24041	258	2	used	use	VERB
brj-24041	258	3	in	in	ADP
brj-24041	258	4	oa	oa	ADP
brj-24041	258	5	treatment	treatment	NOUN
brj-24041	258	6	,	,	PUNCT
brj-24041	258	7	such	such	ADJ
brj-24041	258	8	as	as	ADP
brj-24041	258	9	nonsteroidal	nonsteroidal	NOUN
brj-24041	258	10	antiinflammatory	antiinflammatory	NOUN
brj-24041	258	11	drugs	drug	NOUN
brj-24041	258	12	(	(	PUNCT
brj-24041	258	13	nsaids	nsaids	PROPN
brj-24041	258	14	)	)	PUNCT
brj-24041	258	15	and	and	CCONJ
brj-24041	258	16	corticosteroids	corticosteroid	NOUN
brj-24041	258	17	,	,	PUNCT
brj-24041	258	18	primarily	primarily	ADV
brj-24041	258	19	target	target	VERB
brj-24041	258	20	inflammation	inflammation	NOUN
brj-24041	258	21	to	to	PART
brj-24041	258	22	alleviate	alleviate	VERB
brj-24041	258	23	pain	pain	NOUN
brj-24041	258	24	and	and	CCONJ
brj-24041	258	25	slow	slow	ADJ
brj-24041	258	26	disease	disease	NOUN
brj-24041	258	27	progression	progression	NOUN
brj-24041	258	28	.	.	PUNCT
brj-24041	259	1	antioxidants	antioxidant	NOUN
brj-24041	259	2	,	,	PUNCT
brj-24041	259	3	such	such	ADJ
brj-24041	259	4	as	as	ADP
brj-24041	259	5	vitamin	vitamin	NOUN
brj-24041	259	6	c	c	NOUN
brj-24041	259	7	and	and	CCONJ
brj-24041	259	8	e	e	NOUN
brj-24041	259	9	,	,	PUNCT
brj-24041	259	10	may	may	AUX
brj-24041	259	11	reduce	reduce	VERB
brj-24041	259	12	oxidative	oxidative	ADJ
brj-24041	259	13	stress	stress	NOUN
brj-24041	259	14	,	,	PUNCT
brj-24041	259	15	while	while	SCONJ
brj-24041	259	16	disease	disease	NOUN
brj-24041	259	17	-	-	PUNCT
brj-24041	259	18	modifying	modify	VERB
brj-24041	259	19	osteoarthritis	osteoarthritis	NOUN
brj-24041	259	20	drugs	drug	NOUN
brj-24041	259	21	(	(	PUNCT
brj-24041	259	22	dmoads	dmoad	NOUN
brj-24041	259	23	)	)	PUNCT
brj-24041	259	24	are	be	AUX
brj-24041	259	25	being	be	AUX
brj-24041	259	26	peer	peer	NOUN
brj-24041	259	27	-	-	PUNCT
brj-24041	259	28	reviewed	review	VERB
brj-24041	259	29	article	article	NOUN
brj-24041	259	30	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	259	31	wang	wang	PROPN
brj-24041	259	32	et	et	PROPN
brj-24041	259	33	al	al	PROPN
brj-24041	259	34	.	.	PROPN
brj-24041	260	1	(	(	PUNCT
brj-24041	260	2	2025	2025	NUM
brj-24041	260	3	)	)	PUNCT
brj-24041	260	4	.	.	PUNCT
brj-24041	261	1	“	"	PUNCT
brj-24041	261	2	leaf	leaf	NOUN
brj-24041	261	3	extract	extract	VERB
brj-24041	261	4	anti	anti	ADJ
brj-24041	261	5	-	-	ADJ
brj-24041	261	6	inflammation	inflammation	ADJ
brj-24041	261	7	,	,	PUNCT
brj-24041	261	8	”	"	PUNCT
brj-24041	261	9	bioresources	bioresource	NOUN
brj-24041	261	10	20(1	20(1	NUM
brj-24041	261	11	)	)	PUNCT
brj-24041	261	12	,	,	PUNCT
brj-24041	261	13	956	956	NUM
brj-24041	261	14	-	-	SYM
brj-24041	261	15	971	971	NUM
brj-24041	261	16	.	.	PUNCT
brj-24041	262	1	968	968	NUM
brj-24041	262	2	explored	explore	VERB
brj-24041	262	3	for	for	ADP
brj-24041	262	4	their	their	PRON
brj-24041	262	5	potential	potential	NOUN
brj-24041	262	6	to	to	PART
brj-24041	262	7	curb	curb	VERB
brj-24041	262	8	both	both	DET
brj-24041	262	9	oxidative	oxidative	ADJ
brj-24041	262	10	stress	stress	NOUN
brj-24041	262	11	and	and	CCONJ
brj-24041	262	12	inflammation	inflammation	NOUN
brj-24041	262	13	.	.	PUNCT
brj-24041	263	1	emerging	emerge	VERB
brj-24041	263	2	therapies	therapy	NOUN
brj-24041	263	3	focus	focus	VERB
brj-24041	263	4	on	on	ADP
brj-24041	263	5	modulating	modulate	VERB
brj-24041	263	6	these	these	DET
brj-24041	263	7	pathological	pathological	ADJ
brj-24041	263	8	pathways	pathway	NOUN
brj-24041	263	9	to	to	PART
brj-24041	263	10	offer	offer	VERB
brj-24041	263	11	more	more	ADV
brj-24041	263	12	comprehensive	comprehensive	ADJ
brj-24041	263	13	management	management	NOUN
brj-24041	263	14	of	of	ADP
brj-24041	263	15	oa	oa	PROPN
brj-24041	263	16	(	(	PUNCT
brj-24041	263	17	chen	chen	PROPN
brj-24041	263	18	et	et	PROPN
brj-24041	263	19	al	al	PROPN
brj-24041	263	20	.	.	PROPN
brj-24041	263	21	2021	2021	NUM
brj-24041	263	22	)	)	PUNCT
brj-24041	263	23	.	.	PUNCT
brj-24041	264	1	in	in	ADP
brj-24041	264	2	the	the	DET
brj-24041	264	3	present	present	ADJ
brj-24041	264	4	study	study	NOUN
brj-24041	264	5	,	,	PUNCT
brj-24041	264	6	aqde	aqde	ADV
brj-24041	264	7	was	be	AUX
brj-24041	264	8	found	find	VERB
brj-24041	264	9	to	to	PART
brj-24041	264	10	cause	cause	VERB
brj-24041	264	11	significant	significant	ADJ
brj-24041	264	12	ameliorative	ameliorative	ADJ
brj-24041	264	13	effect	effect	NOUN
brj-24041	264	14	on	on	ADP
brj-24041	264	15	the	the	DET
brj-24041	264	16	oxidative	oxidative	ADJ
brj-24041	264	17	stress	stress	NOUN
brj-24041	264	18	and	and	CCONJ
brj-24041	264	19	inflammation	inflammation	NOUN
brj-24041	264	20	,	,	PUNCT
brj-24041	264	21	thereby	thereby	ADV
brj-24041	264	22	exerting	exert	VERB
brj-24041	264	23	antioxidant	antioxidant	NOUN
brj-24041	264	24	and	and	CCONJ
brj-24041	264	25	anti	anti	ADJ
brj-24041	264	26	-	-	ADJ
brj-24041	264	27	inflammatory	inflammatory	ADJ
brj-24041	264	28	action	action	NOUN
brj-24041	264	29	against	against	ADP
brj-24041	264	30	oa	oa	PRON
brj-24041	264	31	in	in	ADP
brj-24041	264	32	rats	rat	NOUN
brj-24041	264	33	.	.	PUNCT
brj-24041	265	1	cox-2	cox-2	ADV
brj-24041	265	2	(	(	PUNCT
brj-24041	265	3	cyclooxygenase-2	cyclooxygenase-2	NUM
brj-24041	265	4	)	)	PUNCT
brj-24041	265	5	and	and	CCONJ
brj-24041	265	6	nf	nf	NOUN
brj-24041	265	7	-	-	PUNCT
brj-24041	265	8	κb	κb	NOUN
brj-24041	265	9	(	(	PUNCT
brj-24041	265	10	nuclear	nuclear	ADJ
brj-24041	265	11	factor	factor	NOUN
brj-24041	265	12	kappa	kappa	ADJ
brj-24041	265	13	-	-	ADJ
brj-24041	265	14	light	light	ADJ
brj-24041	265	15	-	-	PUNCT
brj-24041	265	16	chain	chain	NOUN
brj-24041	265	17	-	-	PUNCT
brj-24041	265	18	enhancer	enhancer	NOUN
brj-24041	265	19	of	of	ADP
brj-24041	265	20	activated	activated	ADJ
brj-24041	265	21	b	b	PROPN
brj-24041	265	22	cells	cell	NOUN
brj-24041	265	23	)	)	PUNCT
brj-24041	265	24	are	be	AUX
brj-24041	265	25	key	key	ADJ
brj-24041	265	26	molecular	molecular	ADJ
brj-24041	265	27	players	player	NOUN
brj-24041	265	28	in	in	ADP
brj-24041	265	29	the	the	DET
brj-24041	265	30	pathogenesis	pathogenesis	NOUN
brj-24041	265	31	of	of	ADP
brj-24041	265	32	osteoarthritis	osteoarthritis	NOUN
brj-24041	265	33	(	(	PUNCT
brj-24041	265	34	oa	oa	PROPN
brj-24041	265	35	)	)	PUNCT
brj-24041	265	36	(	(	PUNCT
brj-24041	265	37	liu	liu	PROPN
brj-24041	265	38	et	et	PROPN
brj-24041	265	39	al	al	PROPN
brj-24041	265	40	.	.	PROPN
brj-24041	265	41	2017	2017	NUM
brj-24041	265	42	)	)	PUNCT
brj-24041	265	43	.	.	PUNCT
brj-24041	266	1	cox-2	cox-2	ADV
brj-24041	266	2	is	be	AUX
brj-24041	266	3	an	an	DET
brj-24041	266	4	inducible	inducible	ADJ
brj-24041	266	5	enzyme	enzyme	NOUN
brj-24041	266	6	that	that	PRON
brj-24041	266	7	becomes	becomes	AUX
brj-24041	266	8	upregulated	upregulate	VERB
brj-24041	266	9	in	in	ADP
brj-24041	266	10	response	response	NOUN
brj-24041	266	11	to	to	ADP
brj-24041	266	12	pro	pro	ADJ
brj-24041	266	13	-	-	ADJ
brj-24041	266	14	inflammatory	inflammatory	ADJ
brj-24041	266	15	stimuli	stimulus	NOUN
brj-24041	266	16	in	in	ADP
brj-24041	266	17	oa	oa	NOUN
brj-24041	266	18	.	.	PUNCT
brj-24041	267	1	it	it	PRON
brj-24041	267	2	catalyzes	catalyze	VERB
brj-24041	267	3	the	the	DET
brj-24041	267	4	conversion	conversion	NOUN
brj-24041	267	5	of	of	ADP
brj-24041	267	6	arachidonic	arachidonic	ADJ
brj-24041	267	7	acid	acid	NOUN
brj-24041	267	8	to	to	ADP
brj-24041	267	9	prostaglandins	prostaglandin	NOUN
brj-24041	267	10	,	,	PUNCT
brj-24041	267	11	which	which	PRON
brj-24041	267	12	are	be	AUX
brj-24041	267	13	potent	potent	ADJ
brj-24041	267	14	mediators	mediator	NOUN
brj-24041	267	15	of	of	ADP
brj-24041	267	16	inflammation	inflammation	NOUN
brj-24041	267	17	and	and	CCONJ
brj-24041	267	18	pain	pain	NOUN
brj-24041	267	19	.	.	PUNCT
brj-24041	268	1	in	in	ADP
brj-24041	268	2	oa	oa	ADP
brj-24041	268	3	,	,	PUNCT
brj-24041	268	4	excessive	excessive	ADJ
brj-24041	268	5	cox-2	cox-2	ADJ
brj-24041	268	6	activity	activity	NOUN
brj-24041	268	7	leads	lead	VERB
brj-24041	268	8	to	to	ADP
brj-24041	268	9	elevated	elevated	ADJ
brj-24041	268	10	prostaglandin	prostaglandin	NOUN
brj-24041	268	11	levels	level	NOUN
brj-24041	268	12	in	in	ADP
brj-24041	268	13	the	the	DET
brj-24041	268	14	synovial	synovial	ADJ
brj-24041	268	15	fluid	fluid	NOUN
brj-24041	268	16	(	(	PUNCT
brj-24041	268	17	kim	kim	PROPN
brj-24041	268	18	et	et	PROPN
brj-24041	268	19	al	al	PROPN
brj-24041	268	20	.	.	PROPN
brj-24041	268	21	2011	2011	NUM
brj-24041	268	22	)	)	PUNCT
brj-24041	268	23	,	,	PUNCT
brj-24041	268	24	contributing	contribute	VERB
brj-24041	268	25	to	to	ADP
brj-24041	268	26	synovial	synovial	ADJ
brj-24041	268	27	inflammation	inflammation	NOUN
brj-24041	268	28	,	,	PUNCT
brj-24041	268	29	cartilage	cartilage	NOUN
brj-24041	268	30	degradation	degradation	NOUN
brj-24041	268	31	,	,	PUNCT
brj-24041	268	32	and	and	CCONJ
brj-24041	268	33	the	the	DET
brj-24041	268	34	characteristic	characteristic	ADJ
brj-24041	268	35	pain	pain	NOUN
brj-24041	268	36	associated	associate	VERB
brj-24041	268	37	with	with	ADP
brj-24041	268	38	oa	oa	PRON
brj-24041	268	39	.	.	PUNCT
brj-24041	269	1	moreover	moreover	ADV
brj-24041	269	2	,	,	PUNCT
brj-24041	269	3	nf	nf	ADJ
brj-24041	269	4	-	-	PUNCT
brj-24041	269	5	κb	κb	PROPN
brj-24041	269	6	is	be	AUX
brj-24041	269	7	a	a	DET
brj-24041	269	8	transcription	transcription	NOUN
brj-24041	269	9	factor	factor	NOUN
brj-24041	269	10	that	that	PRON
brj-24041	269	11	regulates	regulate	VERB
brj-24041	269	12	the	the	DET
brj-24041	269	13	expression	expression	NOUN
brj-24041	269	14	of	of	ADP
brj-24041	269	15	various	various	ADJ
brj-24041	269	16	genes	gene	NOUN
brj-24041	269	17	involved	involve	VERB
brj-24041	269	18	in	in	ADP
brj-24041	269	19	inflammation	inflammation	NOUN
brj-24041	269	20	,	,	PUNCT
brj-24041	269	21	immune	immune	ADJ
brj-24041	269	22	responses	response	NOUN
brj-24041	269	23	,	,	PUNCT
brj-24041	269	24	and	and	CCONJ
brj-24041	269	25	cell	cell	NOUN
brj-24041	269	26	survival	survival	NOUN
brj-24041	269	27	(	(	PUNCT
brj-24041	269	28	rahman	rahman	NOUN
brj-24041	269	29	and	and	CCONJ
brj-24041	269	30	fazal	fazal	NOUN
brj-24041	269	31	2011	2011	NUM
brj-24041	269	32	)	)	PUNCT
brj-24041	269	33	.	.	PUNCT
brj-24041	270	1	in	in	ADP
brj-24041	270	2	oa	oa	ADP
brj-24041	270	3	,	,	PUNCT
brj-24041	270	4	nf	nf	ADJ
brj-24041	270	5	-	-	PUNCT
brj-24041	270	6	κb	κb	PROPN
brj-24041	270	7	is	be	AUX
brj-24041	270	8	activated	activate	VERB
brj-24041	270	9	by	by	ADP
brj-24041	270	10	inflammatory	inflammatory	ADJ
brj-24041	270	11	cytokines	cytokine	NOUN
brj-24041	270	12	like	like	ADP
brj-24041	270	13	il1β	il1β	PROPN
brj-24041	270	14	and	and	CCONJ
brj-24041	270	15	tnf	tnf	PROPN
brj-24041	270	16	-	-	PUNCT
brj-24041	270	17	α	α	PROPN
brj-24041	270	18	,	,	PUNCT
brj-24041	270	19	leading	lead	VERB
brj-24041	270	20	to	to	ADP
brj-24041	270	21	the	the	DET
brj-24041	270	22	production	production	NOUN
brj-24041	270	23	of	of	ADP
brj-24041	270	24	additional	additional	ADJ
brj-24041	270	25	pro	pro	ADJ
brj-24041	270	26	-	-	ADJ
brj-24041	270	27	inflammatory	inflammatory	ADJ
brj-24041	270	28	mediators	mediator	NOUN
brj-24041	270	29	,	,	PUNCT
brj-24041	270	30	matrix	matrix	NOUN
brj-24041	270	31	metalloproteinases	metalloproteinase	NOUN
brj-24041	270	32	(	(	PUNCT
brj-24041	270	33	mmps	mmp	NOUN
brj-24041	270	34	)	)	PUNCT
brj-24041	270	35	,	,	PUNCT
brj-24041	270	36	and	and	CCONJ
brj-24041	270	37	cox-2	cox-2	NOUN
brj-24041	270	38	.	.	PUNCT
brj-24041	271	1	this	this	PRON
brj-24041	271	2	creates	create	VERB
brj-24041	271	3	a	a	DET
brj-24041	271	4	vicious	vicious	ADJ
brj-24041	271	5	cycle	cycle	NOUN
brj-24041	271	6	,	,	PUNCT
brj-24041	271	7	where	where	SCONJ
brj-24041	271	8	inflammation	inflammation	NOUN
brj-24041	271	9	perpetuates	perpetuate	VERB
brj-24041	271	10	cartilage	cartilage	NOUN
brj-24041	271	11	breakdown	breakdown	NOUN
brj-24041	271	12	and	and	CCONJ
brj-24041	271	13	joint	joint	ADJ
brj-24041	271	14	damage	damage	NOUN
brj-24041	271	15	(	(	PUNCT
brj-24041	271	16	khongthong	khongthong	PROPN
brj-24041	271	17	et	et	PROPN
brj-24041	271	18	al	al	PROPN
brj-24041	271	19	.	.	PROPN
brj-24041	271	20	2019	2019	NUM
brj-24041	271	21	)	)	PUNCT
brj-24041	271	22	.	.	PUNCT
brj-24041	272	1	thus	thus	ADV
brj-24041	272	2	,	,	PUNCT
brj-24041	272	3	in	in	ADP
brj-24041	272	4	the	the	DET
brj-24041	272	5	present	present	ADJ
brj-24041	272	6	study	study	NOUN
brj-24041	272	7	,	,	PUNCT
brj-24041	272	8	the	the	DET
brj-24041	272	9	effect	effect	NOUN
brj-24041	272	10	of	of	ADP
brj-24041	272	11	aqde	aqde	ADV
brj-24041	272	12	on	on	ADP
brj-24041	272	13	the	the	DET
brj-24041	272	14	both	both	DET
brj-24041	272	15	these	these	DET
brj-24041	272	16	mediators	mediator	NOUN
brj-24041	272	17	on	on	ADP
brj-24041	272	18	rat	rat	NOUN
brj-24041	272	19	chondrocytes	chondrocyte	NOUN
brj-24041	272	20	and	and	CCONJ
brj-24041	272	21	cartilage	cartilage	NOUN
brj-24041	272	22	of	of	ADP
brj-24041	272	23	mia	mia	PROPN
brj-24041	272	24	rats	rat	NOUN
brj-24041	272	25	was	be	AUX
brj-24041	272	26	examined	examine	VERB
brj-24041	272	27	.	.	PUNCT
brj-24041	273	1	the	the	DET
brj-24041	273	2	results	result	NOUN
brj-24041	273	3	indicate	indicate	VERB
brj-24041	273	4	that	that	SCONJ
brj-24041	273	5	aqde	aqde	ADV
brj-24041	273	6	significantly	significantly	ADV
brj-24041	273	7	reduces	reduce	VERB
brj-24041	273	8	nf	nf	NOUN
brj-24041	273	9	-	-	PUNCT
brj-24041	273	10	κb	κb	NOUN
brj-24041	273	11	and	and	CCONJ
brj-24041	273	12	cox-2	cox-2	ADJ
brj-24041	273	13	levels	level	NOUN
brj-24041	273	14	both	both	CCONJ
brj-24041	273	15	in	in	ADP
brj-24041	273	16	vitro	vitro	X
brj-24041	273	17	and	and	CCONJ
brj-24041	273	18	in	in	ADP
brj-24041	273	19	vivo	vivo	NOUN
brj-24041	273	20	,	,	PUNCT
brj-24041	273	21	suggesting	suggest	VERB
brj-24041	273	22	that	that	SCONJ
brj-24041	273	23	its	its	PRON
brj-24041	273	24	anti	anti	ADJ
brj-24041	273	25	-	-	ADJ
brj-24041	273	26	inflammatory	inflammatory	ADJ
brj-24041	273	27	effects	effect	NOUN
brj-24041	273	28	in	in	ADP
brj-24041	273	29	oa	oa	ADP
brj-24041	273	30	rats	rat	NOUN
brj-24041	273	31	are	be	AUX
brj-24041	273	32	mediated	mediate	VERB
brj-24041	273	33	through	through	ADP
brj-24041	273	34	the	the	DET
brj-24041	273	35	inhibition	inhibition	NOUN
brj-24041	273	36	of	of	ADP
brj-24041	273	37	these	these	DET
brj-24041	273	38	pathways	pathway	NOUN
brj-24041	273	39	.	.	PUNCT
brj-24041	274	1	however	however	ADV
brj-24041	274	2	,	,	PUNCT
brj-24041	274	3	future	future	ADJ
brj-24041	274	4	studies	study	NOUN
brj-24041	274	5	need	need	VERB
brj-24041	274	6	to	to	PART
brj-24041	274	7	determine	determine	VERB
brj-24041	274	8	the	the	DET
brj-24041	274	9	possible	possible	ADJ
brj-24041	274	10	active	active	ADJ
brj-24041	274	11	component	component	NOUN
brj-24041	274	12	of	of	ADP
brj-24041	274	13	the	the	DET
brj-24041	274	14	extract	extract	NOUN
brj-24041	274	15	to	to	PART
brj-24041	274	16	translate	translate	VERB
brj-24041	274	17	for	for	ADP
brj-24041	274	18	future	future	ADJ
brj-24041	274	19	clinical	clinical	ADJ
brj-24041	274	20	usage	usage	NOUN
brj-24041	274	21	.	.	PUNCT
brj-24041	275	1	conclusions	conclusion	NOUN
brj-24041	275	2	1	1	NUM
brj-24041	275	3	.	.	PUNCT
brj-24041	275	4	anti	anti	ADJ
brj-24041	275	5	-	-	ADJ
brj-24041	275	6	inflammatory	inflammatory	ADJ
brj-24041	275	7	and	and	CCONJ
brj-24041	275	8	antioxidant	antioxidant	ADJ
brj-24041	275	9	effects	effect	NOUN
brj-24041	275	10	:	:	PUNCT
brj-24041	275	11	akebia	akebia	PROPN
brj-24041	275	12	quinata	quinata	VERB
brj-24041	275	13	d.	d.	PROPN
brj-24041	275	14	aqueous	aqueous	PROPN
brj-24041	275	15	extract	extract	NOUN
brj-24041	275	16	(	(	PUNCT
brj-24041	275	17	aqde	aqde	ADV
brj-24041	275	18	)	)	PUNCT
brj-24041	275	19	was	be	AUX
brj-24041	275	20	found	find	VERB
brj-24041	275	21	to	to	PART
brj-24041	275	22	exhibit	exhibit	VERB
brj-24041	275	23	significant	significant	ADJ
brj-24041	275	24	anti	anti	ADJ
brj-24041	275	25	-	-	ADJ
brj-24041	275	26	inflammatory	inflammatory	ADJ
brj-24041	275	27	and	and	CCONJ
brj-24041	275	28	antioxidant	antioxidant	ADJ
brj-24041	275	29	properties	property	NOUN
brj-24041	275	30	by	by	ADP
brj-24041	275	31	modulating	modulate	VERB
brj-24041	275	32	biomarkers	biomarker	NOUN
brj-24041	275	33	such	such	ADJ
brj-24041	275	34	as	as	ADP
brj-24041	275	35	il-1β	il-1β	PROPN
brj-24041	275	36	,	,	PUNCT
brj-24041	275	37	il-6	il-6	PRON
brj-24041	275	38	,	,	PUNCT
brj-24041	275	39	mmp-13	mmp-13	PROPN
brj-24041	275	40	,	,	PUNCT
brj-24041	275	41	and	and	CCONJ
brj-24041	275	42	ptgs2	ptgs2	PROPN
brj-24041	275	43	,	,	PUNCT
brj-24041	275	44	while	while	SCONJ
brj-24041	275	45	restoring	restore	VERB
brj-24041	275	46	oxidative	oxidative	ADJ
brj-24041	275	47	stress	stress	NOUN
brj-24041	275	48	markers	marker	NOUN
brj-24041	275	49	(	(	PUNCT
brj-24041	275	50	mda	mda	PROPN
brj-24041	275	51	,	,	PUNCT
brj-24041	275	52	sod	sod	NOUN
brj-24041	275	53	,	,	PUNCT
brj-24041	275	54	and	and	CCONJ
brj-24041	275	55	gsh	gsh	PROPN
brj-24041	275	56	)	)	PUNCT
brj-24041	275	57	to	to	ADP
brj-24041	275	58	near	near	ADV
brj-24041	275	59	-	-	PUNCT
brj-24041	275	60	normal	normal	ADJ
brj-24041	275	61	levels	level	NOUN
brj-24041	275	62	.	.	PUNCT
brj-24041	276	1	2	2	X
brj-24041	276	2	.	.	X
brj-24041	276	3	cellular	cellular	ADJ
brj-24041	276	4	protection	protection	NOUN
brj-24041	276	5	:	:	PUNCT
brj-24041	276	6	aqde	aqde	ADV
brj-24041	276	7	enhanced	enhance	VERB
brj-24041	276	8	the	the	DET
brj-24041	276	9	expression	expression	NOUN
brj-24041	276	10	of	of	ADP
brj-24041	276	11	protective	protective	ADJ
brj-24041	276	12	proteins	protein	NOUN
brj-24041	276	13	(	(	PUNCT
brj-24041	276	14	bcl2	bcl2	PROPN
brj-24041	276	15	,	,	PUNCT
brj-24041	276	16	cdk1	cdk1	PROPN
brj-24041	276	17	,	,	PUNCT
brj-24041	276	18	ccnd	ccnd	PROPN
brj-24041	276	19	)	)	PUNCT
brj-24041	276	20	and	and	CCONJ
brj-24041	276	21	reduced	reduce	VERB
brj-24041	276	22	chondrocyte	chondrocyte	NOUN
brj-24041	276	23	apoptosis	apoptosis	NOUN
brj-24041	276	24	,	,	PUNCT
brj-24041	276	25	promoting	promote	VERB
brj-24041	276	26	cartilage	cartilage	NOUN
brj-24041	276	27	health	health	NOUN
brj-24041	276	28	.	.	PUNCT
brj-24041	277	1	3	3	X
brj-24041	277	2	.	.	X
brj-24041	277	3	in	in	ADP
brj-24041	277	4	vivo	vivo	ADJ
brj-24041	277	5	efficacy	efficacy	NOUN
brj-24041	277	6	:	:	PUNCT
brj-24041	277	7	aqde	aqde	ADV
brj-24041	277	8	improved	improve	VERB
brj-24041	277	9	mechanical	mechanical	ADJ
brj-24041	277	10	allodynia	allodynia	NOUN
brj-24041	277	11	,	,	PUNCT
brj-24041	277	12	reduced	reduce	VERB
brj-24041	277	13	joint	joint	ADJ
brj-24041	277	14	swelling	swelling	NOUN
brj-24041	277	15	,	,	PUNCT
brj-24041	277	16	and	and	CCONJ
brj-24041	277	17	mitigated	mitigate	VERB
brj-24041	277	18	bone	bone	NOUN
brj-24041	277	19	erosion	erosion	NOUN
brj-24041	277	20	in	in	ADP
brj-24041	277	21	osteoarthritis	osteoarthritis	NOUN
brj-24041	277	22	(	(	PUNCT
brj-24041	277	23	oa	oa	NOUN
brj-24041	277	24	)	)	PUNCT
brj-24041	277	25	rats	rat	NOUN
brj-24041	277	26	,	,	PUNCT
brj-24041	277	27	as	as	SCONJ
brj-24041	277	28	confirmed	confirm	VERB
brj-24041	277	29	by	by	ADP
brj-24041	277	30	micro	micro	NOUN
brj-24041	277	31	-	-	PROPN
brj-24041	277	32	ct	ct	ADJ
brj-24041	277	33	imaging	imaging	NOUN
brj-24041	277	34	.	.	PUNCT
brj-24041	278	1	4	4	X
brj-24041	278	2	.	.	X
brj-24041	278	3	mechanistic	mechanistic	ADJ
brj-24041	278	4	insight	insight	NOUN
brj-24041	278	5	:	:	PUNCT
brj-24041	278	6	the	the	DET
brj-24041	278	7	anti	anti	ADJ
brj-24041	278	8	-	-	ADJ
brj-24041	278	9	osteoarthritis	osteoarthritis	ADJ
brj-24041	278	10	effects	effect	NOUN
brj-24041	278	11	of	of	ADP
brj-24041	278	12	aqde	aqde	ADV
brj-24041	278	13	were	be	AUX
brj-24041	278	14	mediated	mediate	VERB
brj-24041	278	15	via	via	ADP
brj-24041	278	16	inhibition	inhibition	NOUN
brj-24041	278	17	of	of	ADP
brj-24041	278	18	cox-2	cox-2	NOUN
brj-24041	278	19	and	and	CCONJ
brj-24041	278	20	nf	nf	ADJ
brj-24041	278	21	-	-	PUNCT
brj-24041	278	22	κb	κb	NOUN
brj-24041	278	23	expression	expression	NOUN
brj-24041	278	24	,	,	PUNCT
brj-24041	278	25	highlighting	highlight	VERB
brj-24041	278	26	its	its	PRON
brj-24041	278	27	potential	potential	NOUN
brj-24041	278	28	as	as	ADP
brj-24041	278	29	a	a	DET
brj-24041	278	30	therapeutic	therapeutic	ADJ
brj-24041	278	31	agent	agent	NOUN
brj-24041	278	32	for	for	ADP
brj-24041	278	33	oa	oa	NOUN
brj-24041	278	34	.	.	PUNCT
brj-24041	279	1	acknowledgments	acknowledgment	NOUN
brj-24041	279	2	the	the	DET
brj-24041	279	3	authors	author	NOUN
brj-24041	279	4	are	be	AUX
brj-24041	279	5	grateful	grateful	ADJ
brj-24041	279	6	for	for	ADP
brj-24041	279	7	the	the	DET
brj-24041	279	8	support	support	NOUN
brj-24041	279	9	of	of	ADP
brj-24041	279	10	their	their	PRON
brj-24041	279	11	respective	respective	ADJ
brj-24041	279	12	institutes	institute	NOUN
brj-24041	279	13	.	.	PUNCT
brj-24041	280	1	peer	peer	NOUN
brj-24041	280	2	-	-	PUNCT
brj-24041	280	3	reviewed	review	VERB
brj-24041	280	4	article	article	NOUN
brj-24041	280	5	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	280	6	wang	wang	PROPN
brj-24041	280	7	et	et	PROPN
brj-24041	280	8	al	al	PROPN
brj-24041	280	9	.	.	PROPN
brj-24041	281	1	(	(	PUNCT
brj-24041	281	2	2025	2025	NUM
brj-24041	281	3	)	)	PUNCT
brj-24041	281	4	.	.	PUNCT
brj-24041	282	1	“	"	PUNCT
brj-24041	282	2	leaf	leaf	NOUN
brj-24041	282	3	extract	extract	VERB
brj-24041	282	4	anti	anti	ADJ
brj-24041	282	5	-	-	ADJ
brj-24041	282	6	inflammation	inflammation	ADJ
brj-24041	282	7	,	,	PUNCT
brj-24041	282	8	”	"	PUNCT
brj-24041	282	9	bioresources	bioresource	NOUN
brj-24041	282	10	20(1	20(1	NUM
brj-24041	282	11	)	)	PUNCT
brj-24041	282	12	,	,	PUNCT
brj-24041	282	13	956	956	NUM
brj-24041	282	14	-	-	SYM
brj-24041	282	15	971	971	NUM
brj-24041	282	16	.	.	PUNCT
brj-24041	283	1	969	969	NUM
brj-24041	283	2	references	reference	NOUN
brj-24041	283	3	cited	cite	VERB
brj-24041	283	4	“	"	PUNCT
brj-24041	283	5	akebia	akebia	PROPN
brj-24041	283	6	quinata	quinata	ADJ
brj-24041	283	7	(	(	PUNCT
brj-24041	283	8	five	five	NUM
brj-24041	283	9	-	-	PUNCT
brj-24041	283	10	leaf	leaf	NOUN
brj-24041	283	11	akebia	akebia	NOUN
brj-24041	283	12	)	)	PUNCT
brj-24041	283	13	.	.	PUNCT
brj-24041	283	14	”	"	PUNCT
brj-24041	284	1	(	(	PUNCT
brj-24041	284	2	2022	2022	NUM
brj-24041	284	3	)	)	PUNCT
brj-24041	284	4	.	.	PUNCT
brj-24041	285	1	plantwiseplus	plantwiseplus	PROPN
brj-24041	285	2	knowledge	knowledge	PROPN
brj-24041	285	3	bank	bank	PROPN
brj-24041	285	4	,	,	PUNCT
brj-24041	285	5	species	species	NOUN
brj-24041	285	6	pages	page	NOUN
brj-24041	285	7	.	.	PUNCT
brj-24041	286	1	doi	doi	NOUN
brj-24041	286	2	:	:	PUNCT
brj-24041	286	3	10.1079	10.1079	NUM
brj-24041	286	4	/	/	SYM
brj-24041	286	5	pwkb.species.3933	pwkb.species.3933	PROPN
brj-24041	286	6	aubourg	aubourg	PROPN
brj-24041	286	7	,	,	PUNCT
brj-24041	286	8	g.	g.	PROPN
brj-24041	286	9	,	,	PUNCT
brj-24041	286	10	rice	rice	PROPN
brj-24041	286	11	,	,	PUNCT
brj-24041	286	12	s.	s.	PROPN
brj-24041	286	13	j.	j.	PROPN
brj-24041	286	14	,	,	PUNCT
brj-24041	286	15	bruce	bruce	PROPN
brj-24041	286	16	-	-	PUNCT
brj-24041	286	17	wootton	wootton	PROPN
brj-24041	286	18	,	,	PUNCT
brj-24041	286	19	p.	p.	NOUN
brj-24041	286	20	,	,	PUNCT
brj-24041	286	21	and	and	CCONJ
brj-24041	286	22	loughlin	loughlin	PROPN
brj-24041	286	23	,	,	PUNCT
brj-24041	286	24	j.	j.	PROPN
brj-24041	286	25	(	(	PUNCT
brj-24041	286	26	2022	2022	NUM
brj-24041	286	27	)	)	PUNCT
brj-24041	286	28	.	.	PUNCT
brj-24041	287	1	“	"	PUNCT
brj-24041	287	2	genetics	genetic	NOUN
brj-24041	287	3	of	of	ADP
brj-24041	287	4	osteoarthritis	osteoarthritis	NOUN
brj-24041	287	5	,	,	PUNCT
brj-24041	287	6	”	"	PUNCT
brj-24041	287	7	osteoarthritis	osteoarthritis	NOUN
brj-24041	287	8	and	and	CCONJ
brj-24041	287	9	cartilage	cartilage	NOUN
brj-24041	287	10	30(5	30(5	NUM
brj-24041	287	11	)	)	PUNCT
brj-24041	287	12	,	,	PUNCT
brj-24041	287	13	636	636	NUM
brj-24041	287	14	-	-	SYM
brj-24041	287	15	649	649	NUM
brj-24041	287	16	.	.	PUNCT
brj-24041	288	1	doi	doi	NOUN
brj-24041	288	2	:	:	PUNCT
brj-24041	288	3	10.1016	10.1016	NUM
brj-24041	288	4	/	/	SYM
brj-24041	288	5	j.joca.2021.03.002	j.joca.2021.03.002	PROPN
brj-24041	288	6	chatterjee	chatterjee	PROPN
brj-24041	288	7	,	,	PUNCT
brj-24041	288	8	s.	s.	PROPN
brj-24041	288	9	(	(	PUNCT
brj-24041	288	10	2016	2016	NUM
brj-24041	288	11	)	)	PUNCT
brj-24041	288	12	.	.	PUNCT
brj-24041	289	1	“	"	PUNCT
brj-24041	289	2	oxidative	oxidative	ADJ
brj-24041	289	3	stress	stress	NOUN
brj-24041	289	4	,	,	PUNCT
brj-24041	289	5	inflammation	inflammation	NOUN
brj-24041	289	6	,	,	PUNCT
brj-24041	289	7	and	and	CCONJ
brj-24041	289	8	disease	disease	NOUN
brj-24041	289	9	,	,	PUNCT
brj-24041	289	10	”	"	PUNCT
brj-24041	289	11	in	in	ADP
brj-24041	289	12	:	:	PUNCT
brj-24041	289	13	oxidative	oxidative	ADJ
brj-24041	289	14	stress	stress	NOUN
brj-24041	289	15	and	and	CCONJ
brj-24041	289	16	biomaterials	biomaterial	NOUN
brj-24041	289	17	2016	2016	NUM
brj-24041	289	18	,	,	PUNCT
brj-24041	289	19	35	35	NUM
brj-24041	289	20	-	-	SYM
brj-24041	289	21	58	58	NUM
brj-24041	289	22	.	.	PUNCT
brj-24041	290	1	doi	doi	NOUN
brj-24041	290	2	:	:	PUNCT
brj-24041	290	3	10.1016	10.1016	NUM
brj-24041	290	4	/	/	SYM
brj-24041	290	5	b978	b978	NUM
brj-24041	290	6	-	-	PUNCT
brj-24041	290	7	0	0	NUM
brj-24041	290	8	-	-	PUNCT
brj-24041	290	9	12	12	NUM
brj-24041	290	10	-	-	PUNCT
brj-24041	290	11	803269	803269	NUM
brj-24041	290	12	-	-	PUNCT
brj-24041	290	13	5.00002	5.00002	NUM
brj-24041	290	14	-	-	SYM
brj-24041	290	15	4	4	NUM
brj-24041	290	16	chen	chen	PROPN
brj-24041	290	17	,	,	PUNCT
brj-24041	290	18	y.	y.	PROPN
brj-24041	290	19	l.	l.	PROPN
brj-24041	290	20	,	,	PUNCT
brj-24041	290	21	yan	yan	PROPN
brj-24041	290	22	,	,	PUNCT
brj-24041	290	23	d.	d.	PROPN
brj-24041	290	24	y.	y.	PROPN
brj-24041	290	25	,	,	PUNCT
brj-24041	290	26	wu	wu	PROPN
brj-24041	290	27	,	,	PUNCT
brj-24041	290	28	c.	c.	PROPN
brj-24041	290	29	y.	y.	PROPN
brj-24041	290	30	,	,	PUNCT
brj-24041	290	31	xuan	xuan	PROPN
brj-24041	290	32	,	,	PUNCT
brj-24041	290	33	j.	j.	PROPN
brj-24041	290	34	w.	w.	PROPN
brj-24041	290	35	,	,	PUNCT
brj-24041	290	36	jin	jin	PROPN
brj-24041	290	37	,	,	PUNCT
brj-24041	290	38	c.	c.	PROPN
brj-24041	290	39	q.	q.	PROPN
brj-24041	290	40	,	,	PUNCT
brj-24041	290	41	hu	hu	PROPN
brj-24041	290	42	,	,	PUNCT
brj-24041	290	43	x.	x.	PROPN
brj-24041	290	44	l.	l.	PROPN
brj-24041	290	45	,	,	PUNCT
brj-24041	290	46	bao	bao	PROPN
brj-24041	290	47	,	,	PUNCT
brj-24041	290	48	g.	g.	PROPN
brj-24041	290	49	d.	d.	PROPN
brj-24041	290	50	,	,	PUNCT
brj-24041	290	51	bian	bian	PROPN
brj-24041	290	52	,	,	PUNCT
brj-24041	290	53	y.	y.	PROPN
brj-24041	290	54	j.	j.	PROPN
brj-24041	290	55	,	,	PUNCT
brj-24041	290	56	hu	hu	PROPN
brj-24041	290	57	,	,	PUNCT
brj-24041	290	58	z.	z.	PROPN
brj-24041	290	59	c.	c.	PROPN
brj-24041	290	60	,	,	PUNCT
brj-24041	290	61	shen	shen	PROPN
brj-24041	290	62	,	,	PUNCT
brj-24041	290	63	z.	z.	PROPN
brj-24041	290	64	h.	h.	PROPN
brj-24041	290	65	,	,	PUNCT
brj-24041	290	66	and	and	CCONJ
brj-24041	290	67	ni	ni	PROPN
brj-24041	290	68	,	,	PUNCT
brj-24041	290	69	w.	w.	PROPN
brj-24041	290	70	f.	f.	PROPN
brj-24041	290	71	(	(	PUNCT
brj-24041	290	72	2021	2021	NUM
brj-24041	290	73	)	)	PUNCT
brj-24041	290	74	.	.	PUNCT
brj-24041	291	1	“	"	PUNCT
brj-24041	291	2	maslinic	maslinic	ADJ
brj-24041	291	3	acid	acid	NOUN
brj-24041	291	4	prevents	prevent	VERB
brj-24041	291	5	il-1βinduced	il-1βinduce	VERB
brj-24041	291	6	inflammatory	inflammatory	ADJ
brj-24041	291	7	response	response	NOUN
brj-24041	291	8	in	in	ADP
brj-24041	291	9	osteoarthritis	osteoarthritis	NOUN
brj-24041	291	10	via	via	ADP
brj-24041	291	11	pi3k	pi3k	PROPN
brj-24041	291	12	/	/	SYM
brj-24041	291	13	akt	akt	PROPN
brj-24041	291	14	/	/	SYM
brj-24041	291	15	nf	nf	PROPN
brj-24041	291	16	-	-	PUNCT
brj-24041	291	17	κb	κb	NOUN
brj-24041	291	18	pathways	pathway	NOUN
brj-24041	291	19	,	,	PUNCT
brj-24041	291	20	”	"	PUNCT
brj-24041	291	21	journal	journal	NOUN
brj-24041	291	22	of	of	ADP
brj-24041	291	23	cellular	cellular	ADJ
brj-24041	291	24	physiology	physiology	NOUN
brj-24041	291	25	236(3	236(3	NUM
brj-24041	291	26	)	)	PUNCT
brj-24041	291	27	,	,	PUNCT
brj-24041	291	28	article	article	NOUN
brj-24041	291	29	29977	29977	NUM
brj-24041	291	30	.	.	PUNCT
brj-24041	292	1	doi	doi	NOUN
brj-24041	292	2	:	:	PUNCT
brj-24041	292	3	10.1002	10.1002	NUM
brj-24041	292	4	/	/	SYM
brj-24041	292	5	jcp.29977	jcp.29977	PROPN
brj-24041	292	6	eccleston	eccleston	PROPN
brj-24041	292	7	,	,	PUNCT
brj-24041	292	8	a.	a.	NOUN
brj-24041	292	9	(	(	PUNCT
brj-24041	292	10	2023	2023	NUM
brj-24041	292	11	)	)	PUNCT
brj-24041	292	12	.	.	PUNCT
brj-24041	293	1	“	"	PUNCT
brj-24041	293	2	cartilage	cartilage	NOUN
brj-24041	293	3	regeneration	regeneration	NOUN
brj-24041	293	4	for	for	ADP
brj-24041	293	5	osteoarthritis	osteoarthritis	NOUN
brj-24041	293	6	,	,	PUNCT
brj-24041	293	7	”	"	PUNCT
brj-24041	293	8	nature	nature	NOUN
brj-24041	293	9	reviews	review	VERB
brj-24041	293	10	drug	drug	NOUN
brj-24041	293	11	discovery	discovery	PROPN
brj-24041	293	12	22(2	22(2	NUM
brj-24041	293	13	)	)	PUNCT
brj-24041	293	14	,	,	PUNCT
brj-24041	293	15	article	article	NOUN
brj-24041	293	16	96	96	NUM
brj-24041	293	17	.	.	PUNCT
brj-24041	294	1	doi	doi	NOUN
brj-24041	294	2	:	:	PUNCT
brj-24041	294	3	10.1038	10.1038	NUM
brj-24041	294	4	/	/	SYM
brj-24041	294	5	d41573	d41573	PROPN
brj-24041	294	6	-	-	PUNCT
brj-24041	294	7	022	022	NUM
brj-24041	294	8	-	-	PUNCT
brj-24041	294	9	00215	00215	NUM
brj-24041	294	10	-	-	PUNCT
brj-24041	294	11	x	x	SYM
brj-24041	294	12	eitner	eitner	NOUN
brj-24041	294	13	,	,	PUNCT
brj-24041	294	14	a.	a.	PROPN
brj-24041	294	15	,	,	PUNCT
brj-24041	294	16	hofmann	hofmann	PROPN
brj-24041	294	17	,	,	PUNCT
brj-24041	294	18	g.	g.	PROPN
brj-24041	294	19	o.	o.	PROPN
brj-24041	294	20	,	,	PUNCT
brj-24041	294	21	and	and	CCONJ
brj-24041	294	22	schaible	schaible	ADJ
brj-24041	294	23	,	,	PUNCT
brj-24041	294	24	h.	h.	PROPN
brj-24041	294	25	g.	g.	PROPN
brj-24041	294	26	(	(	PUNCT
brj-24041	294	27	2020	2020	NUM
brj-24041	294	28	)	)	PUNCT
brj-24041	294	29	.	.	PUNCT
brj-24041	295	1	“	"	PUNCT
brj-24041	295	2	the	the	DET
brj-24041	295	3	pathophysiology	pathophysiology	NOUN
brj-24041	295	4	of	of	ADP
brj-24041	295	5	osteoarthritis	osteoarthritis	NOUN
brj-24041	295	6	pain	pain	NOUN
brj-24041	295	7	,	,	PUNCT
brj-24041	295	8	”	"	PUNCT
brj-24041	295	9	tagliche	tagliche	NOUN
brj-24041	295	10	praxis	praxi	VERB
brj-24041	295	11	61(1	61(1	NUM
brj-24041	295	12	)	)	PUNCT
brj-24041	295	13	.	.	PUNCT
brj-24041	296	1	fan	fan	PROPN
brj-24041	296	2	,	,	PUNCT
brj-24041	296	3	h.	h.	PROPN
brj-24041	296	4	w.	w.	PROPN
brj-24041	296	5	,	,	PUNCT
brj-24041	296	6	liu	liu	PROPN
brj-24041	296	7	,	,	PUNCT
brj-24041	296	8	g.	g.	PROPN
brj-24041	296	9	y.	y.	PROPN
brj-24041	296	10	,	,	PUNCT
brj-24041	296	11	zhao	zhao	PROPN
brj-24041	296	12	,	,	PUNCT
brj-24041	296	13	c.	c.	PROPN
brj-24041	296	14	f.	f.	PROPN
brj-24041	296	15	,	,	PUNCT
brj-24041	296	16	li	li	PROPN
brj-24041	296	17	,	,	PUNCT
brj-24041	296	18	x.	x.	PROPN
brj-24041	296	19	f.	f.	PROPN
brj-24041	296	20	,	,	PUNCT
brj-24041	296	21	and	and	CCONJ
brj-24041	296	22	yang	yang	PROPN
brj-24041	296	23	,	,	PUNCT
brj-24041	296	24	x.	x.	PROPN
brj-24041	296	25	y.	y.	PROPN
brj-24041	296	26	(	(	PUNCT
brj-24041	296	27	2015	2015	NUM
brj-24041	296	28	)	)	PUNCT
brj-24041	296	29	.	.	PUNCT
brj-24041	297	1	“	"	PUNCT
brj-24041	297	2	differential	differential	ADJ
brj-24041	297	3	expression	expression	NOUN
brj-24041	297	4	of	of	ADP
brj-24041	297	5	cox-2	cox-2	NOUN
brj-24041	297	6	in	in	ADP
brj-24041	297	7	osteoarthritis	osteoarthritis	NOUN
brj-24041	297	8	and	and	CCONJ
brj-24041	297	9	rheumatoid	rheumatoid	VERB
brj-24041	297	10	arthritis	arthritis	NOUN
brj-24041	297	11	,	,	PUNCT
brj-24041	297	12	”	"	PUNCT
brj-24041	297	13	genetics	genetic	NOUN
brj-24041	297	14	and	and	CCONJ
brj-24041	297	15	molecular	molecular	ADJ
brj-24041	297	16	research	research	NOUN
brj-24041	297	17	14(4	14(4	NOUN
brj-24041	297	18	)	)	PUNCT
brj-24041	297	19	,	,	PUNCT
brj-24041	297	20	12872	12872	NUM
brj-24041	297	21	-	-	SYM
brj-24041	297	22	12879	12879	NUM
brj-24041	297	23	.	.	PUNCT
brj-24041	298	1	doi	doi	NOUN
brj-24041	298	2	:	:	PUNCT
brj-24041	298	3	10.4238/2015.october.21.7	10.4238/2015.october.21.7	NUM
brj-24041	298	4	fernández	fernández	PROPN
brj-24041	298	5	-	-	PUNCT
brj-24041	298	6	sánchez	sánchez	PROPN
brj-24041	298	7	,	,	PUNCT
brj-24041	298	8	a.	a.	NOUN
brj-24041	298	9	,	,	PUNCT
brj-24041	298	10	madrigal	madrigal	NOUN
brj-24041	298	11	-	-	PUNCT
brj-24041	298	12	santillán	santillán	NOUN
brj-24041	298	13	,	,	PUNCT
brj-24041	298	14	e.	e.	PROPN
brj-24041	298	15	,	,	PUNCT
brj-24041	298	16	bautista	bautista	PROPN
brj-24041	298	17	,	,	PUNCT
brj-24041	298	18	m.	m.	NOUN
brj-24041	298	19	,	,	PUNCT
brj-24041	298	20	esquivel	esquivel	PROPN
brj-24041	298	21	-	-	PUNCT
brj-24041	298	22	soto	soto	PROPN
brj-24041	298	23	,	,	PUNCT
brj-24041	298	24	j.	j.	PROPN
brj-24041	298	25	,	,	PUNCT
brj-24041	298	26	moralesgonzález	moralesgonzález	PROPN
brj-24041	298	27	,	,	PUNCT
brj-24041	298	28	á	á	PROPN
brj-24041	298	29	.	.	PROPN
brj-24041	298	30	,	,	PUNCT
brj-24041	298	31	esquivel	esquivel	PROPN
brj-24041	298	32	-	-	PUNCT
brj-24041	298	33	chirino	chirino	PROPN
brj-24041	298	34	,	,	PUNCT
brj-24041	298	35	c.	c.	PROPN
brj-24041	298	36	,	,	PUNCT
brj-24041	298	37	durante	durante	PROPN
brj-24041	298	38	-	-	PUNCT
brj-24041	298	39	montiel	montiel	PROPN
brj-24041	298	40	,	,	PUNCT
brj-24041	298	41	i.	i.	PROPN
brj-24041	298	42	,	,	PUNCT
brj-24041	298	43	sánchez	sánchez	NOUN
brj-24041	298	44	-	-	PUNCT
brj-24041	298	45	rivera	rivera	PROPN
brj-24041	298	46	,	,	PUNCT
brj-24041	298	47	g.	g.	PROPN
brj-24041	298	48	,	,	PUNCT
brj-24041	298	49	valadez	valadez	PROPN
brj-24041	298	50	-	-	PUNCT
brj-24041	298	51	vega	vega	PROPN
brj-24041	298	52	,	,	PUNCT
brj-24041	298	53	c.	c.	PROPN
brj-24041	298	54	,	,	PUNCT
brj-24041	298	55	and	and	CCONJ
brj-24041	298	56	morales	morales	PROPN
brj-24041	298	57	-	-	PUNCT
brj-24041	298	58	gonzález	gonzález	PROPN
brj-24041	298	59	,	,	PUNCT
brj-24041	298	60	j.	j.	PROPN
brj-24041	298	61	a.	a.	PROPN
brj-24041	298	62	(	(	PUNCT
brj-24041	298	63	2011	2011	NUM
brj-24041	298	64	)	)	PUNCT
brj-24041	298	65	.	.	PUNCT
brj-24041	299	1	“	"	PUNCT
brj-24041	299	2	inflammation	inflammation	NOUN
brj-24041	299	3	,	,	PUNCT
brj-24041	299	4	oxidative	oxidative	ADJ
brj-24041	299	5	stress	stress	NOUN
brj-24041	299	6	,	,	PUNCT
brj-24041	299	7	and	and	CCONJ
brj-24041	299	8	obesity	obesity	NOUN
brj-24041	299	9	,	,	PUNCT
brj-24041	299	10	”	"	PUNCT
brj-24041	299	11	international	international	ADJ
brj-24041	299	12	journal	journal	NOUN
brj-24041	299	13	of	of	ADP
brj-24041	299	14	molecular	molecular	ADJ
brj-24041	299	15	sciences	science	NOUN
brj-24041	299	16	12(5	12(5	NUM
brj-24041	299	17	)	)	PUNCT
brj-24041	299	18	,	,	PUNCT
brj-24041	299	19	3117	3117	NUM
brj-24041	299	20	-	-	SYM
brj-24041	299	21	3132	3132	NUM
brj-24041	299	22	.	.	PUNCT
brj-24041	300	1	doi	doi	NOUN
brj-24041	300	2	:	:	PUNCT
brj-24041	300	3	10.3390	10.3390	NUM
brj-24041	300	4	/	/	SYM
brj-24041	300	5	ijms12053117	ijms12053117	PROPN
brj-24041	300	6	fusco	fusco	PROPN
brj-24041	300	7	,	,	PUNCT
brj-24041	300	8	r.	r.	PROPN
brj-24041	300	9	,	,	PUNCT
brj-24041	300	10	siracusa	siracusa	PROPN
brj-24041	300	11	,	,	PUNCT
brj-24041	300	12	r.	r.	PROPN
brj-24041	300	13	,	,	PUNCT
brj-24041	300	14	peritore	peritore	NOUN
brj-24041	300	15	,	,	PUNCT
brj-24041	300	16	a.	a.	PROPN
brj-24041	300	17	f.	f.	PROPN
brj-24041	300	18	,	,	PUNCT
brj-24041	300	19	gugliandolo	gugliandolo	PROPN
brj-24041	300	20	,	,	PUNCT
brj-24041	300	21	e.	e.	PROPN
brj-24041	300	22	,	,	PUNCT
brj-24041	300	23	genovese	genovese	NOUN
brj-24041	300	24	,	,	PUNCT
brj-24041	300	25	t.	t.	NOUN
brj-24041	300	26	,	,	PUNCT
brj-24041	300	27	d’amico	d’amico	PROPN
brj-24041	300	28	,	,	PUNCT
brj-24041	300	29	r.	r.	PROPN
brj-24041	300	30	,	,	PUNCT
brj-24041	300	31	cordaro	cordaro	NOUN
brj-24041	300	32	,	,	PUNCT
brj-24041	300	33	m.	m.	NOUN
brj-24041	300	34	,	,	PUNCT
brj-24041	300	35	crupi	crupi	PROPN
brj-24041	300	36	,	,	PUNCT
brj-24041	300	37	r.	r.	PROPN
brj-24041	300	38	,	,	PUNCT
brj-24041	300	39	mandalari	mandalari	PROPN
brj-24041	300	40	,	,	PUNCT
brj-24041	300	41	g.	g.	PROPN
brj-24041	300	42	,	,	PUNCT
brj-24041	300	43	impellizzeri	impellizzeri	PROPN
brj-24041	300	44	,	,	PUNCT
brj-24041	300	45	d.	d.	PROPN
brj-24041	300	46	,	,	PUNCT
brj-24041	300	47	cuzzocrea	cuzzocrea	PROPN
brj-24041	300	48	,	,	PUNCT
brj-24041	300	49	s.	s.	PROPN
brj-24041	300	50	,	,	PUNCT
brj-24041	300	51	and	and	CCONJ
brj-24041	300	52	di	di	PROPN
brj-24041	300	53	paola	paola	PROPN
brj-24041	300	54	,	,	PUNCT
brj-24041	300	55	r.	r.	PROPN
brj-24041	300	56	(	(	PUNCT
brj-24041	300	57	2020	2020	NUM
brj-24041	300	58	)	)	PUNCT
brj-24041	300	59	.	.	PUNCT
brj-24041	301	1	“	"	PUNCT
brj-24041	301	2	the	the	DET
brj-24041	301	3	role	role	NOUN
brj-24041	301	4	of	of	ADP
brj-24041	301	5	cashew	cashew	NOUN
brj-24041	301	6	(	(	PUNCT
brj-24041	301	7	anacardium	anacardium	PROPN
brj-24041	301	8	occidentale	occidentale	PROPN
brj-24041	301	9	l.	l.	PROPN
brj-24041	301	10	)	)	PUNCT
brj-24041	301	11	nuts	nut	NOUN
brj-24041	301	12	on	on	ADP
brj-24041	301	13	an	an	DET
brj-24041	301	14	experimental	experimental	ADJ
brj-24041	301	15	model	model	NOUN
brj-24041	301	16	of	of	ADP
brj-24041	301	17	painful	painful	ADJ
brj-24041	301	18	degenerative	degenerative	ADJ
brj-24041	301	19	joint	joint	ADJ
brj-24041	301	20	disease	disease	NOUN
brj-24041	301	21	,	,	PUNCT
brj-24041	301	22	”	"	PUNCT
brj-24041	301	23	antioxidants	antioxidant	NOUN
brj-24041	301	24	9(6	9(6	NUM
brj-24041	301	25	)	)	PUNCT
brj-24041	301	26	,	,	PUNCT
brj-24041	301	27	article	article	NOUN
brj-24041	301	28	511	511	NUM
brj-24041	301	29	.	.	PUNCT
brj-24041	302	1	doi	doi	NOUN
brj-24041	302	2	:	:	PUNCT
brj-24041	302	3	10.3390	10.3390	NUM
brj-24041	302	4	/	/	SYM
brj-24041	302	5	antiox9060511	antiox9060511	PROPN
brj-24041	302	6	grässel	grässel	NOUN
brj-24041	302	7	,	,	PUNCT
brj-24041	302	8	s.	s.	PROPN
brj-24041	302	9	,	,	PUNCT
brj-24041	302	10	and	and	CCONJ
brj-24041	302	11	muschter	muschter	PROPN
brj-24041	302	12	,	,	PUNCT
brj-24041	302	13	d.	d.	PROPN
brj-24041	302	14	(	(	PUNCT
brj-24041	302	15	2020	2020	NUM
brj-24041	302	16	)	)	PUNCT
brj-24041	302	17	.	.	PUNCT
brj-24041	303	1	“	"	PUNCT
brj-24041	303	2	recent	recent	ADJ
brj-24041	303	3	advances	advance	NOUN
brj-24041	303	4	in	in	ADP
brj-24041	303	5	the	the	DET
brj-24041	303	6	treatment	treatment	NOUN
brj-24041	303	7	of	of	ADP
brj-24041	303	8	osteoarthritis	osteoarthritis	NOUN
brj-24041	303	9	,	,	PUNCT
brj-24041	303	10	”	"	PUNCT
brj-24041	303	11	f1000research	f1000research	NOUN
brj-24041	303	12	.	.	PUNCT
brj-24041	304	1	doi	doi	NOUN
brj-24041	304	2	:	:	PUNCT
brj-24041	304	3	10.12688	10.12688	NUM
brj-24041	304	4	/	/	SYM
brj-24041	304	5	f1000research.22115.1	f1000research.22115.1	PROPN
brj-24041	304	6	han	han	PROPN
brj-24041	304	7	,	,	PUNCT
brj-24041	304	8	s.	s.	PROPN
brj-24041	304	9	h.	h.	PROPN
brj-24041	304	10	,	,	PUNCT
brj-24041	304	11	kim	kim	PROPN
brj-24041	304	12	,	,	PUNCT
brj-24041	304	13	y.	y.	PROPN
brj-24041	304	14	w.	w.	PROPN
brj-24041	304	15	,	,	PUNCT
brj-24041	304	16	and	and	CCONJ
brj-24041	304	17	hyun	hyun	PROPN
brj-24041	304	18	,	,	PUNCT
brj-24041	304	19	c.	c.	NOUN
brj-24041	304	20	(	(	PUNCT
brj-24041	304	21	2012	2012	NUM
brj-24041	304	22	)	)	PUNCT
brj-24041	304	23	.	.	PUNCT
brj-24041	305	1	“	"	PUNCT
brj-24041	305	2	evaluation	evaluation	NOUN
brj-24041	305	3	of	of	ADP
brj-24041	305	4	diuretic	diuretic	ADJ
brj-24041	305	5	and	and	CCONJ
brj-24041	305	6	hemodynamic	hemodynamic	ADJ
brj-24041	305	7	effect	effect	NOUN
brj-24041	305	8	of	of	ADP
brj-24041	305	9	extract	extract	NOUN
brj-24041	305	10	from	from	ADP
brj-24041	305	11	akebia	akebia	PROPN
brj-24041	305	12	quinata	quinata	ADJ
brj-24041	305	13	decaisne	decaisne	NOUN
brj-24041	305	14	in	in	ADP
brj-24041	305	15	dogs	dog	NOUN
brj-24041	305	16	,	,	PUNCT
brj-24041	305	17	”	"	PUNCT
brj-24041	305	18	journal	journal	NOUN
brj-24041	305	19	of	of	ADP
brj-24041	305	20	veterinary	veterinary	ADJ
brj-24041	305	21	clinics	clinic	NOUN
brj-24041	305	22	29(3	29(3	NUM
brj-24041	305	23	)	)	PUNCT
brj-24041	305	24	.	.	PUNCT
brj-24041	306	1	jonason	jonason	PROPN
brj-24041	306	2	,	,	PUNCT
brj-24041	306	3	j.	j.	PROPN
brj-24041	306	4	h.	h.	PROPN
brj-24041	306	5	,	,	PUNCT
brj-24041	306	6	hoak	hoak	PROPN
brj-24041	306	7	,	,	PUNCT
brj-24041	306	8	d.	d.	PROPN
brj-24041	306	9	,	,	PUNCT
brj-24041	306	10	and	and	CCONJ
brj-24041	306	11	o’keefe	o’keefe	NUM
brj-24041	306	12	,	,	PUNCT
brj-24041	306	13	r.	r.	PROPN
brj-24041	306	14	j.	j.	PROPN
brj-24041	306	15	(	(	PUNCT
brj-24041	306	16	2015	2015	NUM
brj-24041	306	17	)	)	PUNCT
brj-24041	306	18	.	.	PUNCT
brj-24041	307	1	“	"	PUNCT
brj-24041	307	2	primary	primary	ADJ
brj-24041	307	3	murine	murine	ADJ
brj-24041	307	4	growth	growth	NOUN
brj-24041	307	5	plate	plate	NOUN
brj-24041	307	6	and	and	CCONJ
brj-24041	307	7	articular	articular	ADJ
brj-24041	307	8	chondrocyte	chondrocyte	NOUN
brj-24041	307	9	isolation	isolation	NOUN
brj-24041	307	10	and	and	CCONJ
brj-24041	307	11	cell	cell	NOUN
brj-24041	307	12	culture	culture	NOUN
brj-24041	307	13	,	,	PUNCT
brj-24041	307	14	”	"	PUNCT
brj-24041	307	15	methods	method	NOUN
brj-24041	307	16	in	in	ADP
brj-24041	307	17	molecular	molecular	ADJ
brj-24041	307	18	biology	biology	NOUN
brj-24041	307	19	1226	1226	NUM
brj-24041	307	20	.	.	PUNCT
brj-24041	308	1	doi	doi	NOUN
brj-24041	308	2	:	:	PUNCT
brj-24041	308	3	10.1007/978	10.1007/978	NUM
brj-24041	308	4	-	-	SYM
brj-24041	308	5	1	1	NUM
brj-24041	308	6	-	-	PUNCT
brj-24041	308	7	4939	4939	NUM
brj-24041	308	8	-	-	PUNCT
brj-24041	308	9	1619	1619	NUM
brj-24041	308	10	-	-	SYM
brj-24041	308	11	1_2	1_2	NUM
brj-24041	308	12	katturajan	katturajan	PROPN
brj-24041	308	13	,	,	PUNCT
brj-24041	308	14	r.	r.	PROPN
brj-24041	308	15	,	,	PUNCT
brj-24041	308	16	and	and	CCONJ
brj-24041	308	17	sabina	sabina	PROPN
brj-24041	308	18	,	,	PUNCT
brj-24041	308	19	e.	e.	PROPN
brj-24041	308	20	p.	p.	PROPN
brj-24041	308	21	(	(	PUNCT
brj-24041	308	22	2021	2021	NUM
brj-24041	308	23	)	)	PUNCT
brj-24041	308	24	.	.	PUNCT
brj-24041	309	1	“	"	PUNCT
brj-24041	309	2	joint	joint	ADJ
brj-24041	309	3	inflammation	inflammation	NOUN
brj-24041	309	4	:	:	PUNCT
brj-24041	309	5	insights	insight	NOUN
brj-24041	309	6	of	of	ADP
brj-24041	309	7	osteoarthritis	osteoarthritis	NOUN
brj-24041	309	8	,	,	PUNCT
brj-24041	309	9	gouty	gouty	NOUN
brj-24041	309	10	and	and	CCONJ
brj-24041	309	11	rheumatoid	rheumatoid	VERB
brj-24041	309	12	arthritis	arthritis	NOUN
brj-24041	309	13	and	and	CCONJ
brj-24041	309	14	its	its	PRON
brj-24041	309	15	prevalence	prevalence	NOUN
brj-24041	309	16	,	,	PUNCT
brj-24041	309	17	mechanism	mechanism	NOUN
brj-24041	309	18	,	,	PUNCT
brj-24041	309	19	medications	medication	NOUN
brj-24041	309	20	and	and	CCONJ
brj-24041	309	21	remedies	remedy	NOUN
brj-24041	309	22	,	,	PUNCT
brj-24041	309	23	”	"	PUNCT
brj-24041	309	24	indian	indian	ADJ
brj-24041	309	25	journal	journal	NOUN
brj-24041	309	26	of	of	ADP
brj-24041	309	27	pharmaceutical	pharmaceutical	PROPN
brj-24041	309	28	sciences	science	NOUN
brj-24041	309	29	83(5	83(5	NOUN
brj-24041	309	30	)	)	PUNCT
brj-24041	309	31	,	,	PUNCT
brj-24041	309	32	886	886	NUM
brj-24041	309	33	-	-	SYM
brj-24041	309	34	898	898	NUM
brj-24041	309	35	.	.	PUNCT
brj-24041	310	1	doi	doi	NOUN
brj-24041	310	2	:	:	PUNCT
brj-24041	310	3	10.36468	10.36468	NUM
brj-24041	310	4	/	/	SYM
brj-24041	310	5	pharmaceutical	pharmaceutical	NOUN
brj-24041	310	6	-	-	PUNCT
brj-24041	310	7	sciences.840	sciences.840	NOUN
brj-24041	310	8	khongthong	khongthong	PROPN
brj-24041	310	9	,	,	PUNCT
brj-24041	310	10	p.	p.	PROPN
brj-24041	310	11	,	,	PUNCT
brj-24041	310	12	roseweir	roseweir	ADJ
brj-24041	310	13	,	,	PUNCT
brj-24041	310	14	a.	a.	NOUN
brj-24041	310	15	k.	k.	PROPN
brj-24041	310	16	,	,	PUNCT
brj-24041	310	17	and	and	CCONJ
brj-24041	310	18	edwards	edwards	PROPN
brj-24041	310	19	,	,	PUNCT
brj-24041	310	20	j.	j.	PROPN
brj-24041	310	21	(	(	PUNCT
brj-24041	310	22	2019	2019	NUM
brj-24041	310	23	)	)	PUNCT
brj-24041	310	24	.	.	PUNCT
brj-24041	311	1	“	"	PUNCT
brj-24041	311	2	the	the	DET
brj-24041	311	3	nf	nf	PROPN
brj-24041	311	4	-	-	PUNCT
brj-24041	311	5	kb	kb	NOUN
brj-24041	311	6	pathway	pathway	NOUN
brj-24041	311	7	and	and	CCONJ
brj-24041	311	8	endocrine	endocrine	NOUN
brj-24041	311	9	therapy	therapy	NOUN
brj-24041	311	10	resistance	resistance	NOUN
brj-24041	311	11	in	in	ADP
brj-24041	311	12	breast	breast	NOUN
brj-24041	311	13	cancer	cancer	NOUN
brj-24041	311	14	,	,	PUNCT
brj-24041	311	15	”	"	PUNCT
brj-24041	311	16	endocrine	endocrine	NOUN
brj-24041	311	17	-	-	PUNCT
brj-24041	311	18	related	relate	VERB
brj-24041	311	19	cancer	cancer	NOUN
brj-24041	311	20	26(6	26(6	NOUN
brj-24041	311	21	)	)	PUNCT
brj-24041	311	22	,	,	PUNCT
brj-24041	311	23	r369	r369	PROPN
brj-24041	311	24	-	-	PUNCT
brj-24041	311	25	r380	r380	PROPN
brj-24041	311	26	.	.	PUNCT
brj-24041	311	27	doi	doi	NOUN
brj-24041	311	28	:	:	PUNCT
brj-24041	311	29	10.1530	10.1530	NUM
brj-24041	311	30	/	/	SYM
brj-24041	311	31	erc-19	erc-19	NOUN
brj-24041	311	32	-	-	PUNCT
brj-24041	311	33	0087	0087	NUM
brj-24041	311	34	kihara	kihara	NOUN
brj-24041	311	35	,	,	PUNCT
brj-24041	311	36	s.	s.	PROPN
brj-24041	311	37	,	,	PUNCT
brj-24041	311	38	hayashi	hayashi	PROPN
brj-24041	311	39	,	,	PUNCT
brj-24041	311	40	s.	s.	PROPN
brj-24041	311	41	,	,	PUNCT
brj-24041	311	42	hashimoto	hashimoto	NOUN
brj-24041	311	43	,	,	PUNCT
brj-24041	311	44	s.	s.	PROPN
brj-24041	311	45	,	,	PUNCT
brj-24041	311	46	kanzaki	kanzaki	PROPN
brj-24041	311	47	,	,	PUNCT
brj-24041	311	48	n.	n.	NOUN
brj-24041	311	49	,	,	PUNCT
brj-24041	311	50	takayama	takayama	PROPN
brj-24041	311	51	,	,	PUNCT
brj-24041	311	52	k.	k.	PROPN
brj-24041	311	53	,	,	PUNCT
brj-24041	311	54	matsumoto	matsumoto	PROPN
brj-24041	311	55	,	,	PUNCT
brj-24041	311	56	t.	t.	PROPN
brj-24041	311	57	,	,	PUNCT
brj-24041	311	58	chinzei	chinzei	VERB
brj-24041	311	59	,	,	PUNCT
brj-24041	311	60	n.	n.	NOUN
brj-24041	311	61	,	,	PUNCT
brj-24041	311	62	iwasa	iwasa	PROPN
brj-24041	311	63	,	,	PUNCT
brj-24041	311	64	k.	k.	PROPN
brj-24041	311	65	,	,	PUNCT
brj-24041	311	66	haneda	haneda	PROPN
brj-24041	311	67	,	,	PUNCT
brj-24041	311	68	m.	m.	NOUN
brj-24041	311	69	,	,	PUNCT
brj-24041	311	70	takeuchi	takeuchi	PROPN
brj-24041	311	71	,	,	PUNCT
brj-24041	311	72	k.	k.	PROPN
brj-24041	311	73	,	,	PUNCT
brj-24041	311	74	nishida	nishida	PROPN
brj-24041	311	75	,	,	PUNCT
brj-24041	311	76	k.	k.	PROPN
brj-24041	311	77	,	,	PUNCT
brj-24041	311	78	and	and	CCONJ
brj-24041	311	79	kuroda	kuroda	PROPN
brj-24041	311	80	,	,	PUNCT
brj-24041	311	81	r.	r.	PROPN
brj-24041	311	82	(	(	PUNCT
brj-24041	311	83	2017	2017	NUM
brj-24041	311	84	)	)	PUNCT
brj-24041	311	85	.	.	PUNCT
brj-24041	312	1	“	"	PUNCT
brj-24041	312	2	cyclin	cyclin	NOUN
brj-24041	312	3	-	-	PUNCT
brj-24041	312	4	dependent	dependent	ADJ
brj-24041	312	5	kinase	kinase	NOUN
brj-24041	312	6	inhibitor-1	inhibitor-1	NUM
brj-24041	312	7	-	-	PUNCT
brj-24041	312	8	deficient	deficient	ADJ
brj-24041	312	9	mice	mouse	NOUN
brj-24041	312	10	are	be	AUX
brj-24041	312	11	susceptible	susceptible	ADJ
brj-24041	312	12	to	to	ADP
brj-24041	312	13	osteoarthritis	osteoarthritis	NOUN
brj-24041	312	14	peer	peer	NOUN
brj-24041	312	15	-	-	PUNCT
brj-24041	312	16	reviewed	review	VERB
brj-24041	312	17	article	article	NOUN
brj-24041	312	18	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	312	19	wang	wang	PROPN
brj-24041	312	20	et	et	PROPN
brj-24041	312	21	al	al	PROPN
brj-24041	312	22	.	.	PROPN
brj-24041	313	1	(	(	PUNCT
brj-24041	313	2	2025	2025	NUM
brj-24041	313	3	)	)	PUNCT
brj-24041	313	4	.	.	PUNCT
brj-24041	314	1	“	"	PUNCT
brj-24041	314	2	leaf	leaf	NOUN
brj-24041	314	3	extract	extract	VERB
brj-24041	314	4	anti	anti	ADJ
brj-24041	314	5	-	-	ADJ
brj-24041	314	6	inflammation	inflammation	ADJ
brj-24041	314	7	,	,	PUNCT
brj-24041	314	8	”	"	PUNCT
brj-24041	314	9	bioresources	bioresource	NOUN
brj-24041	314	10	20(1	20(1	NUM
brj-24041	314	11	)	)	PUNCT
brj-24041	314	12	,	,	PUNCT
brj-24041	314	13	956	956	NUM
brj-24041	314	14	-	-	SYM
brj-24041	314	15	971	971	NUM
brj-24041	314	16	.	.	PUNCT
brj-24041	315	1	970	970	NUM
brj-24041	315	2	associated	associate	VERB
brj-24041	315	3	with	with	ADP
brj-24041	315	4	enhanced	enhanced	ADJ
brj-24041	315	5	inflammation	inflammation	NOUN
brj-24041	315	6	,	,	PUNCT
brj-24041	315	7	”	"	PUNCT
brj-24041	315	8	journal	journal	NOUN
brj-24041	315	9	of	of	ADP
brj-24041	315	10	bone	bone	NOUN
brj-24041	315	11	and	and	CCONJ
brj-24041	315	12	mineral	mineral	NOUN
brj-24041	315	13	research	research	NOUN
brj-24041	315	14	32(5	32(5	NOUN
brj-24041	315	15	)	)	PUNCT
brj-24041	315	16	,	,	PUNCT
brj-24041	315	17	991	991	NUM
brj-24041	315	18	-	-	SYM
brj-24041	315	19	1001	1001	NUM
brj-24041	315	20	.	.	PUNCT
brj-24041	316	1	doi	doi	NOUN
brj-24041	316	2	:	:	PUNCT
brj-24041	316	3	10.1002	10.1002	NUM
brj-24041	316	4	/	/	SYM
brj-24041	316	5	jbmr.3080	jbmr.3080	PROPN
brj-24041	316	6	kim	kim	PROPN
brj-24041	316	7	,	,	PUNCT
brj-24041	316	8	k.	k.	PROPN
brj-24041	316	9	,	,	PUNCT
brj-24041	316	10	lee	lee	PROPN
brj-24041	316	11	,	,	PUNCT
brj-24041	316	12	s.	s.	PROPN
brj-24041	316	13	,	,	PUNCT
brj-24041	316	14	shin	shin	PROPN
brj-24041	316	15	,	,	PUNCT
brj-24041	316	16	s.	s.	PROPN
brj-24041	316	17	,	,	PUNCT
brj-24041	316	18	kim	kim	PROPN
brj-24041	316	19	,	,	PUNCT
brj-24041	316	20	h.	h.	PROPN
brj-24041	316	21	,	,	PUNCT
brj-24041	316	22	han	han	PROPN
brj-24041	316	23	,	,	PUNCT
brj-24041	316	24	s.	s.	PROPN
brj-24041	316	25	,	,	PUNCT
brj-24041	316	26	kim	kim	PROPN
brj-24041	316	27	,	,	PUNCT
brj-24041	316	28	k.	k.	PROPN
brj-24041	316	29	,	,	PUNCT
brj-24041	316	30	kwon	kwon	PROPN
brj-24041	316	31	,	,	PUNCT
brj-24041	316	32	j.	j.	PROPN
brj-24041	316	33	,	,	PUNCT
brj-24041	316	34	kwak	kwak	PROPN
brj-24041	316	35	,	,	PUNCT
brj-24041	316	36	j.	j.	PROPN
brj-24041	316	37	h.	h.	PROPN
brj-24041	316	38	,	,	PUNCT
brj-24041	316	39	lee	lee	PROPN
brj-24041	316	40	,	,	PUNCT
brj-24041	316	41	c.	c.	PROPN
brj-24041	316	42	k.	k.	PROPN
brj-24041	316	43	,	,	PUNCT
brj-24041	316	44	ha	ha	INTJ
brj-24041	316	45	,	,	PUNCT
brj-24041	316	46	n.	n.	PROPN
brj-24041	316	47	j.	j.	PROPN
brj-24041	316	48	,	,	PUNCT
brj-24041	316	49	and	and	CCONJ
brj-24041	316	50	yim	yim	PROPN
brj-24041	316	51	,	,	PUNCT
brj-24041	316	52	d.	d.	PROPN
brj-24041	316	53	(	(	PUNCT
brj-24041	316	54	2011	2011	NUM
brj-24041	316	55	)	)	PUNCT
brj-24041	316	56	.	.	PUNCT
brj-24041	317	1	“	"	PUNCT
brj-24041	317	2	anti	anti	ADJ
brj-24041	317	3	-	-	ADJ
brj-24041	317	4	inflammatory	inflammatory	ADJ
brj-24041	317	5	function	function	NOUN
brj-24041	317	6	of	of	ADP
brj-24041	317	7	arctiin	arctiin	NOUN
brj-24041	317	8	by	by	ADP
brj-24041	317	9	inhibiting	inhibit	VERB
brj-24041	317	10	cox-2	cox-2	ADJ
brj-24041	317	11	expression	expression	NOUN
brj-24041	317	12	via	via	ADP
brj-24041	317	13	nf	nf	NOUN
brj-24041	317	14	-	-	PUNCT
brj-24041	317	15	κb	κb	NOUN
brj-24041	317	16	pathways	pathway	NOUN
brj-24041	317	17	,	,	PUNCT
brj-24041	317	18	”	"	PUNCT
brj-24041	317	19	journal	journal	NOUN
brj-24041	317	20	of	of	ADP
brj-24041	317	21	inflammation	inflammation	NOUN
brj-24041	317	22	8	8	NUM
brj-24041	317	23	,	,	PUNCT
brj-24041	317	24	article	article	NOUN
brj-24041	317	25	16	16	NUM
brj-24041	317	26	.	.	PUNCT
brj-24041	318	1	doi	doi	NOUN
brj-24041	318	2	:	:	PUNCT
brj-24041	318	3	10.1186/1476	10.1186/1476	NUM
brj-24041	318	4	-	-	SYM
brj-24041	318	5	9255	9255	NUM
brj-24041	318	6	-	-	PUNCT
brj-24041	318	7	8	8	NUM
brj-24041	318	8	-	-	SYM
brj-24041	318	9	16	16	NUM
brj-24041	318	10	lee	lee	PROPN
brj-24041	318	11	,	,	PUNCT
brj-24041	318	12	y.	y.	PROPN
brj-24041	318	13	m.	m.	PROPN
brj-24041	318	14	,	,	PUNCT
brj-24041	318	15	son	son	PROPN
brj-24041	318	16	,	,	PUNCT
brj-24041	318	17	e.	e.	PROPN
brj-24041	318	18	,	,	PUNCT
brj-24041	318	19	kim	kim	PROPN
brj-24041	318	20	,	,	PUNCT
brj-24041	318	21	s.	s.	PROPN
brj-24041	318	22	h.	h.	PROPN
brj-24041	318	23	,	,	PUNCT
brj-24041	318	24	and	and	CCONJ
brj-24041	318	25	kim	kim	PROPN
brj-24041	318	26	,	,	PUNCT
brj-24041	318	27	d.	d.	PROPN
brj-24041	318	28	s.	s.	PROPN
brj-24041	318	29	(	(	PUNCT
brj-24041	318	30	2022a	2022a	NUM
brj-24041	318	31	)	)	PUNCT
brj-24041	318	32	.	.	PUNCT
brj-24041	319	1	“	"	PUNCT
brj-24041	319	2	anti	anti	ADJ
brj-24041	319	3	-	-	ADJ
brj-24041	319	4	inflammatory	inflammatory	ADJ
brj-24041	319	5	and	and	CCONJ
brj-24041	319	6	analgesic	analgesic	ADJ
brj-24041	319	7	effects	effect	NOUN
brj-24041	319	8	of	of	ADP
brj-24041	319	9	schisandra	schisandra	NOUN
brj-24041	319	10	chinensis	chinensis	NOUN
brj-24041	319	11	leaf	leaf	NOUN
brj-24041	319	12	extracts	extract	NOUN
brj-24041	319	13	and	and	CCONJ
brj-24041	319	14	monosodium	monosodium	NOUN
brj-24041	319	15	iodoacetateinduced	iodoacetateinduce	VERB
brj-24041	319	16	osteoarthritis	osteoarthritis	NOUN
brj-24041	319	17	in	in	ADP
brj-24041	319	18	rats	rat	NOUN
brj-24041	319	19	and	and	CCONJ
brj-24041	319	20	acetic	acetic	ADJ
brj-24041	319	21	acid	acid	NOUN
brj-24041	319	22	-	-	PUNCT
brj-24041	319	23	induced	induce	VERB
brj-24041	319	24	writhing	writhing	NOUN
brj-24041	319	25	in	in	ADP
brj-24041	319	26	mice	mouse	NOUN
brj-24041	319	27	,	,	PUNCT
brj-24041	319	28	”	"	PUNCT
brj-24041	319	29	nutrients	nutrient	NOUN
brj-24041	319	30	14(7	14(7	NUM
brj-24041	319	31	)	)	PUNCT
brj-24041	319	32	,	,	PUNCT
brj-24041	319	33	article	article	NOUN
brj-24041	319	34	1356	1356	NUM
brj-24041	319	35	.	.	PUNCT
brj-24041	320	1	doi	doi	NOUN
brj-24041	320	2	:	:	PUNCT
brj-24041	320	3	10.3390	10.3390	NUM
brj-24041	320	4	/	/	SYM
brj-24041	320	5	nu14071356	nu14071356	PROPN
brj-24041	320	6	lee	lee	PROPN
brj-24041	320	7	,	,	PUNCT
brj-24041	320	8	y.	y.	PROPN
brj-24041	320	9	t.	t.	PROPN
brj-24041	320	10	,	,	PUNCT
brj-24041	320	11	yunus	yunus	PROPN
brj-24041	320	12	,	,	PUNCT
brj-24041	320	13	m.	m.	NOUN
brj-24041	320	14	h.	h.	PROPN
brj-24041	320	15	m.	m.	PROPN
brj-24041	320	16	,	,	PUNCT
brj-24041	320	17	ugusman	ugusman	NOUN
brj-24041	320	18	,	,	PUNCT
brj-24041	320	19	a.	a.	NOUN
brj-24041	320	20	,	,	PUNCT
brj-24041	320	21	and	and	CCONJ
brj-24041	320	22	yazid	yazid	PROPN
brj-24041	320	23	,	,	PUNCT
brj-24041	320	24	m.	m.	PROPN
brj-24041	320	25	d.	d.	PROPN
brj-24041	320	26	(	(	PUNCT
brj-24041	320	27	2022b	2022b	NUM
brj-24041	320	28	)	)	PUNCT
brj-24041	320	29	.	.	PUNCT
brj-24041	321	1	“	"	PUNCT
brj-24041	321	2	natural	natural	ADJ
brj-24041	321	3	compounds	compound	NOUN
brj-24041	321	4	affecting	affect	VERB
brj-24041	321	5	inflammatory	inflammatory	ADJ
brj-24041	321	6	pathways	pathway	NOUN
brj-24041	321	7	of	of	ADP
brj-24041	321	8	osteoarthritis	osteoarthritis	NOUN
brj-24041	321	9	,	,	PUNCT
brj-24041	321	10	”	"	PUNCT
brj-24041	321	11	antioxidants	antioxidant	NOUN
brj-24041	321	12	11(9	11(9	NUM
brj-24041	321	13	)	)	PUNCT
brj-24041	321	14	,	,	PUNCT
brj-24041	321	15	article	article	NOUN
brj-24041	321	16	1722	1722	NUM
brj-24041	321	17	.	.	PUNCT
brj-24041	322	1	doi	doi	NOUN
brj-24041	322	2	:	:	PUNCT
brj-24041	322	3	10.3390	10.3390	NUM
brj-24041	322	4	/	/	SYM
brj-24041	322	5	antiox11091722	antiox11091722	PROPN
brj-24041	322	6	lin	lin	PROPN
brj-24041	322	7	,	,	PUNCT
brj-24041	322	8	j.	j.	PROPN
brj-24041	322	9	,	,	PUNCT
brj-24041	322	10	jia	jia	PROPN
brj-24041	322	11	,	,	PUNCT
brj-24041	322	12	s.	s.	PROPN
brj-24041	322	13	,	,	PUNCT
brj-24041	322	14	zhang	zhang	PROPN
brj-24041	322	15	,	,	PUNCT
brj-24041	322	16	w.	w.	PROPN
brj-24041	322	17	,	,	PUNCT
brj-24041	322	18	nian	nian	ADJ
brj-24041	322	19	,	,	PUNCT
brj-24041	322	20	m.	m.	NOUN
brj-24041	322	21	,	,	PUNCT
brj-24041	322	22	liu	liu	PROPN
brj-24041	322	23	,	,	PUNCT
brj-24041	322	24	p.	p.	PROPN
brj-24041	322	25	,	,	PUNCT
brj-24041	322	26	yang	yang	PROPN
brj-24041	322	27	,	,	PUNCT
brj-24041	322	28	l.	l.	PROPN
brj-24041	322	29	,	,	PUNCT
brj-24041	322	30	zuo	zuo	PROPN
brj-24041	322	31	,	,	PUNCT
brj-24041	322	32	j.	j.	PROPN
brj-24041	322	33	,	,	PUNCT
brj-24041	322	34	li	li	PROPN
brj-24041	322	35	,	,	PUNCT
brj-24041	322	36	w.	w.	PROPN
brj-24041	322	37	,	,	PUNCT
brj-24041	322	38	zeng	zeng	PROPN
brj-24041	322	39	,	,	PUNCT
brj-24041	322	40	h.	h.	PROPN
brj-24041	322	41	,	,	PUNCT
brj-24041	322	42	and	and	CCONJ
brj-24041	322	43	zhang	zhang	PROPN
brj-24041	322	44	,	,	PUNCT
brj-24041	322	45	x.	x.	NOUN
brj-24041	322	46	(	(	PUNCT
brj-24041	322	47	2023	2023	NUM
brj-24041	322	48	)	)	PUNCT
brj-24041	322	49	.	.	PUNCT
brj-24041	323	1	“	"	PUNCT
brj-24041	323	2	recent	recent	ADJ
brj-24041	323	3	advances	advance	NOUN
brj-24041	323	4	in	in	ADP
brj-24041	323	5	small	small	ADJ
brj-24041	323	6	molecule	molecule	NOUN
brj-24041	323	7	inhibitors	inhibitor	NOUN
brj-24041	323	8	for	for	ADP
brj-24041	323	9	the	the	DET
brj-24041	323	10	treatment	treatment	NOUN
brj-24041	323	11	of	of	ADP
brj-24041	323	12	osteoarthritis	osteoarthritis	NOUN
brj-24041	323	13	,	,	PUNCT
brj-24041	323	14	”	"	PUNCT
brj-24041	323	15	journal	journal	NOUN
brj-24041	323	16	of	of	ADP
brj-24041	323	17	clinical	clinical	ADJ
brj-24041	323	18	medicine	medicine	NOUN
brj-24041	323	19	12(5	12(5	NOUN
brj-24041	323	20	)	)	PUNCT
brj-24041	323	21	,	,	PUNCT
brj-24041	323	22	article	article	NOUN
brj-24041	323	23	1986	1986	NUM
brj-24041	323	24	.	.	PUNCT
brj-24041	324	1	doi	doi	NOUN
brj-24041	324	2	:	:	PUNCT
brj-24041	324	3	10.3390	10.3390	NUM
brj-24041	324	4	/	/	SYM
brj-24041	324	5	jcm12051986	jcm12051986	NOUN
brj-24041	324	6	liu	liu	PROPN
brj-24041	324	7	,	,	PUNCT
brj-24041	324	8	y.	y.	PROPN
brj-24041	324	9	z.	z.	PROPN
brj-24041	324	10	,	,	PUNCT
brj-24041	324	11	wang	wang	PROPN
brj-24041	324	12	,	,	PUNCT
brj-24041	324	13	y.	y.	PROPN
brj-24041	324	14	x.	x.	PROPN
brj-24041	324	15	,	,	PUNCT
brj-24041	324	16	and	and	CCONJ
brj-24041	324	17	jiang	jiang	PROPN
brj-24041	324	18	,	,	PUNCT
brj-24041	324	19	c.	c.	PROPN
brj-24041	324	20	l.	l.	PROPN
brj-24041	324	21	(	(	PUNCT
brj-24041	324	22	2017	2017	NUM
brj-24041	324	23	)	)	PUNCT
brj-24041	324	24	.	.	PUNCT
brj-24041	325	1	“	"	PUNCT
brj-24041	325	2	inflammation	inflammation	NOUN
brj-24041	325	3	:	:	PUNCT
brj-24041	325	4	the	the	DET
brj-24041	325	5	common	common	ADJ
brj-24041	325	6	pathway	pathway	NOUN
brj-24041	325	7	of	of	ADP
brj-24041	325	8	stress	stress	NOUN
brj-24041	325	9	-	-	PUNCT
brj-24041	325	10	related	relate	VERB
brj-24041	325	11	diseases	disease	NOUN
brj-24041	325	12	,	,	PUNCT
brj-24041	325	13	”	"	PUNCT
brj-24041	325	14	frontiers	frontier	NOUN
brj-24041	325	15	in	in	ADP
brj-24041	325	16	human	human	ADJ
brj-24041	325	17	neuroscience	neuroscience	NOUN
brj-24041	325	18	2017	2017	NUM
brj-24041	325	19	,	,	PUNCT
brj-24041	325	20	article	article	NOUN
brj-24041	325	21	316	316	NUM
brj-24041	325	22	.	.	PUNCT
brj-24041	326	1	doi	doi	NOUN
brj-24041	326	2	:	:	PUNCT
brj-24041	326	3	10.3389	10.3389	NUM
brj-24041	326	4	/	/	SYM
brj-24041	326	5	fnhum.2017.00316	fnhum.2017.00316	NUM
brj-24041	326	6	mirando	mirando	NOUN
brj-24041	326	7	,	,	PUNCT
brj-24041	326	8	a.	a.	PROPN
brj-24041	326	9	j.	j.	PROPN
brj-24041	326	10	,	,	PUNCT
brj-24041	326	11	dong	dong	PROPN
brj-24041	326	12	,	,	PUNCT
brj-24041	326	13	y.	y.	PROPN
brj-24041	326	14	,	,	PUNCT
brj-24041	326	15	kim	kim	PROPN
brj-24041	326	16	,	,	PUNCT
brj-24041	326	17	j.	j.	PROPN
brj-24041	326	18	,	,	PUNCT
brj-24041	326	19	and	and	CCONJ
brj-24041	326	20	hilton	hilton	PROPN
brj-24041	326	21	,	,	PUNCT
brj-24041	326	22	m.	m.	NOUN
brj-24041	326	23	j.	j.	PROPN
brj-24041	326	24	(	(	PUNCT
brj-24041	326	25	2014	2014	NUM
brj-24041	326	26	)	)	PUNCT
brj-24041	326	27	.	.	PUNCT
brj-24041	327	1	“	"	PUNCT
brj-24041	327	2	isolation	isolation	NOUN
brj-24041	327	3	and	and	CCONJ
brj-24041	327	4	culture	culture	NOUN
brj-24041	327	5	of	of	ADP
brj-24041	327	6	murine	murine	ADJ
brj-24041	327	7	primary	primary	ADJ
brj-24041	327	8	chondrocytes	chondrocyte	NOUN
brj-24041	327	9	,	,	PUNCT
brj-24041	327	10	”	"	PUNCT
brj-24041	327	11	methods	method	NOUN
brj-24041	327	12	in	in	ADP
brj-24041	327	13	molecular	molecular	ADJ
brj-24041	327	14	biology	biology	NOUN
brj-24041	327	15	1130	1130	NUM
brj-24041	327	16	,	,	PUNCT
brj-24041	327	17	267	267	NUM
brj-24041	327	18	-	-	SYM
brj-24041	327	19	277	277	NUM
brj-24041	327	20	.	.	PUNCT
brj-24041	328	1	doi	doi	NOUN
brj-24041	328	2	:	:	PUNCT
brj-24041	328	3	10.1007/978	10.1007/978	NUM
brj-24041	328	4	-	-	SYM
brj-24041	328	5	1	1	NUM
brj-24041	328	6	-	-	PUNCT
brj-24041	328	7	62703	62703	NUM
brj-24041	328	8	-	-	PUNCT
brj-24041	328	9	989	989	NUM
brj-24041	328	10	-	-	PUNCT
brj-24041	328	11	5_20	5_20	NOUN
brj-24041	328	12	mobasheri	mobasheri	NOUN
brj-24041	328	13	,	,	PUNCT
brj-24041	328	14	a.	a.	NOUN
brj-24041	328	15	,	,	PUNCT
brj-24041	328	16	and	and	CCONJ
brj-24041	328	17	batt	batt	NOUN
brj-24041	328	18	,	,	PUNCT
brj-24041	328	19	m.	m.	NOUN
brj-24041	328	20	(	(	PUNCT
brj-24041	328	21	2016	2016	NUM
brj-24041	328	22	)	)	PUNCT
brj-24041	328	23	.	.	PUNCT
brj-24041	329	1	“	"	PUNCT
brj-24041	329	2	an	an	DET
brj-24041	329	3	update	update	NOUN
brj-24041	329	4	on	on	ADP
brj-24041	329	5	the	the	DET
brj-24041	329	6	pathophysiology	pathophysiology	NOUN
brj-24041	329	7	of	of	ADP
brj-24041	329	8	osteoarthritis	osteoarthritis	NOUN
brj-24041	329	9	,	,	PUNCT
brj-24041	329	10	”	"	PUNCT
brj-24041	329	11	annals	annal	NOUN
brj-24041	329	12	of	of	ADP
brj-24041	329	13	physical	physical	ADJ
brj-24041	329	14	and	and	CCONJ
brj-24041	329	15	rehabilitation	rehabilitation	NOUN
brj-24041	329	16	medicine	medicine	NOUN
brj-24041	329	17	59(5	59(5	NUM
brj-24041	329	18	-	-	SYM
brj-24041	329	19	6	6	NUM
brj-24041	329	20	)	)	PUNCT
brj-24041	329	21	,	,	PUNCT
brj-24041	329	22	333	333	NUM
brj-24041	329	23	-	-	SYM
brj-24041	329	24	339	339	NUM
brj-24041	329	25	.	.	PUNCT
brj-24041	330	1	doi	doi	NOUN
brj-24041	330	2	:	:	PUNCT
brj-24041	330	3	10.1016	10.1016	NUM
brj-24041	330	4	/	/	SYM
brj-24041	330	5	j.rehab.2016.07.004	j.rehab.2016.07.004	X
brj-24041	330	6	de	de	X
brj-24041	330	7	morais	morais	PROPN
brj-24041	330	8	,	,	PUNCT
brj-24041	330	9	s.	s.	PROPN
brj-24041	330	10	v.	v.	PROPN
brj-24041	330	11	,	,	PUNCT
brj-24041	330	12	czeczko	czeczko	PROPN
brj-24041	330	13	,	,	PUNCT
brj-24041	330	14	n.	n.	PROPN
brj-24041	330	15	g.	g.	PROPN
brj-24041	330	16	,	,	PUNCT
brj-24041	330	17	malafaia	malafaia	PROPN
brj-24041	330	18	,	,	PUNCT
brj-24041	330	19	o.	o.	PROPN
brj-24041	330	20	,	,	PUNCT
brj-24041	330	21	filho	filho	PROPN
brj-24041	330	22	,	,	PUNCT
brj-24041	330	23	j.	j.	PROPN
brj-24041	330	24	m.	m.	PROPN
brj-24041	330	25	r.	r.	PROPN
brj-24041	330	26	,	,	PUNCT
brj-24041	330	27	garcia	garcia	PROPN
brj-24041	330	28	,	,	PUNCT
brj-24041	330	29	j.	j.	PROPN
brj-24041	330	30	b.	b.	PROPN
brj-24041	330	31	s.	s.	PROPN
brj-24041	330	32	,	,	PUNCT
brj-24041	330	33	miguel	miguel	PROPN
brj-24041	330	34	,	,	PUNCT
brj-24041	330	35	m.	m.	NOUN
brj-24041	330	36	t.	t.	PROPN
brj-24041	330	37	,	,	PUNCT
brj-24041	330	38	zini	zini	PROPN
brj-24041	330	39	,	,	PUNCT
brj-24041	330	40	c.	c.	NOUN
brj-24041	330	41	,	,	PUNCT
brj-24041	330	42	and	and	CCONJ
brj-24041	330	43	massignan	massignan	NOUN
brj-24041	330	44	,	,	PUNCT
brj-24041	330	45	a.	a.	NOUN
brj-24041	330	46	g.	g.	PROPN
brj-24041	330	47	(	(	PUNCT
brj-24041	330	48	2016	2016	NUM
brj-24041	330	49	)	)	PUNCT
brj-24041	330	50	.	.	PUNCT
brj-24041	331	1	“	"	PUNCT
brj-24041	331	2	osteoarthritis	osteoarthritis	NOUN
brj-24041	331	3	model	model	NOUN
brj-24041	331	4	induced	induce	VERB
brj-24041	331	5	by	by	ADP
brj-24041	331	6	intraarticular	intraarticular	ADJ
brj-24041	331	7	monosodium	monosodium	NOUN
brj-24041	331	8	iodoacetate	iodoacetate	NOUN
brj-24041	331	9	in	in	ADP
brj-24041	331	10	rats	rat	NOUN
brj-24041	331	11	knee	knee	NOUN
brj-24041	331	12	,	,	PUNCT
brj-24041	331	13	”	"	PUNCT
brj-24041	331	14	acta	acta	PROPN
brj-24041	331	15	cirurgica	cirurgica	PROPN
brj-24041	331	16	brasileira	brasileira	PROPN
brj-24041	331	17	31(11	31(11	NUM
brj-24041	331	18	)	)	PUNCT
brj-24041	331	19	,	,	PUNCT
brj-24041	331	20	765	765	PROPN
brj-24041	331	21	-	-	SYM
brj-24041	331	22	773	773	NUM
brj-24041	331	23	.	.	PUNCT
brj-24041	332	1	doi	doi	NOUN
brj-24041	332	2	:	:	PUNCT
brj-24041	332	3	10.1590	10.1590	NUM
brj-24041	332	4	/	/	SYM
brj-24041	332	5	s0102	s0102	NOUN
brj-24041	332	6	-	-	PUNCT
brj-24041	332	7	865020160110000010	865020160110000010	NUM
brj-24041	332	8	musumeci	musumeci	PROPN
brj-24041	332	9	,	,	PUNCT
brj-24041	332	10	g.	g.	PROPN
brj-24041	332	11	,	,	PUNCT
brj-24041	332	12	castrogiovanni	castrogiovanni	NOUN
brj-24041	332	13	,	,	PUNCT
brj-24041	332	14	p.	p.	PROPN
brj-24041	332	15	,	,	PUNCT
brj-24041	332	16	trovato	trovato	PROPN
brj-24041	332	17	,	,	PUNCT
brj-24041	332	18	f.	f.	PROPN
brj-24041	332	19	m.	m.	PROPN
brj-24041	332	20	,	,	PUNCT
brj-24041	332	21	weinberg	weinberg	PROPN
brj-24041	332	22	,	,	PUNCT
brj-24041	332	23	a.	a.	NOUN
brj-24041	332	24	m.	m.	NOUN
brj-24041	332	25	,	,	PUNCT
brj-24041	332	26	al	al	PROPN
brj-24041	332	27	-	-	PUNCT
brj-24041	332	28	wasiyah	wasiyah	PROPN
brj-24041	332	29	,	,	PUNCT
brj-24041	332	30	m.	m.	NOUN
brj-24041	332	31	k.	k.	PROPN
brj-24041	332	32	,	,	PUNCT
brj-24041	332	33	alqahtani	alqahtani	PROPN
brj-24041	332	34	,	,	PUNCT
brj-24041	332	35	m.	m.	NOUN
brj-24041	332	36	h.	h.	PROPN
brj-24041	332	37	,	,	PUNCT
brj-24041	332	38	and	and	CCONJ
brj-24041	332	39	mobasheri	mobasheri	PROPN
brj-24041	332	40	,	,	PUNCT
brj-24041	332	41	a.	a.	NOUN
brj-24041	332	42	(	(	PUNCT
brj-24041	332	43	2015	2015	NUM
brj-24041	332	44	)	)	PUNCT
brj-24041	332	45	.	.	PUNCT
brj-24041	333	1	“	"	PUNCT
brj-24041	333	2	biomarkers	biomarker	NOUN
brj-24041	333	3	of	of	ADP
brj-24041	333	4	chondrocyte	chondrocyte	NOUN
brj-24041	333	5	apoptosis	apoptosis	NOUN
brj-24041	333	6	and	and	CCONJ
brj-24041	333	7	autophagy	autophagy	NOUN
brj-24041	333	8	in	in	ADP
brj-24041	333	9	osteoarthritis	osteoarthritis	NOUN
brj-24041	333	10	,	,	PUNCT
brj-24041	333	11	”	"	PUNCT
brj-24041	333	12	international	international	ADJ
brj-24041	333	13	journal	journal	NOUN
brj-24041	333	14	of	of	ADP
brj-24041	333	15	molecular	molecular	ADJ
brj-24041	333	16	sciences	science	NOUN
brj-24041	333	17	16(9	16(9	NUM
brj-24041	333	18	)	)	PUNCT
brj-24041	333	19	,	,	PUNCT
brj-24041	333	20	20560	20560	NUM
brj-24041	333	21	-	-	SYM
brj-24041	333	22	20575	20575	NUM
brj-24041	333	23	.	.	PUNCT
brj-24041	334	1	doi	doi	NOUN
brj-24041	334	2	:	:	PUNCT
brj-24041	334	3	10.3390	10.3390	NUM
brj-24041	334	4	/	/	SYM
brj-24041	334	5	ijms160920560	ijms160920560	PROPN
brj-24041	334	6	park	park	NOUN
brj-24041	334	7	,	,	PUNCT
brj-24041	334	8	s.	s.	PROPN
brj-24041	334	9	h.	h.	PROPN
brj-24041	334	10	,	,	PUNCT
brj-24041	334	11	jang	jang	PROPN
brj-24041	334	12	,	,	PUNCT
brj-24041	334	13	s.	s.	PROPN
brj-24041	334	14	,	,	PUNCT
brj-24041	334	15	lee	lee	PROPN
brj-24041	334	16	,	,	PUNCT
brj-24041	334	17	s.	s.	PROPN
brj-24041	334	18	w.	w.	PROPN
brj-24041	334	19	,	,	PUNCT
brj-24041	334	20	park	park	PROPN
brj-24041	334	21	,	,	PUNCT
brj-24041	334	22	s.	s.	PROPN
brj-24041	334	23	d.	d.	PROPN
brj-24041	334	24	,	,	PUNCT
brj-24041	334	25	sung	sung	PROPN
brj-24041	334	26	,	,	PUNCT
brj-24041	334	27	y.	y.	PROPN
brj-24041	334	28	y.	y.	PROPN
brj-24041	334	29	,	,	PUNCT
brj-24041	334	30	and	and	CCONJ
brj-24041	334	31	kim	kim	PROPN
brj-24041	334	32	,	,	PUNCT
brj-24041	334	33	h.	h.	PROPN
brj-24041	334	34	k.	k.	PROPN
brj-24041	334	35	(	(	PUNCT
brj-24041	334	36	2018	2018	NUM
brj-24041	334	37	)	)	PUNCT
brj-24041	334	38	.	.	PUNCT
brj-24041	335	1	“	"	PUNCT
brj-24041	335	2	akebia	akebia	PROPN
brj-24041	335	3	quinata	quinata	VERB
brj-24041	335	4	decaisne	decaisne	ADJ
brj-24041	335	5	aqueous	aqueous	ADJ
brj-24041	335	6	extract	extract	NOUN
brj-24041	335	7	acts	act	VERB
brj-24041	335	8	as	as	ADP
brj-24041	335	9	a	a	DET
brj-24041	335	10	novel	novel	ADJ
brj-24041	335	11	anti	anti	ADJ
brj-24041	335	12	-	-	ADJ
brj-24041	335	13	fatigue	fatigue	ADJ
brj-24041	335	14	agent	agent	NOUN
brj-24041	335	15	in	in	ADP
brj-24041	335	16	mice	mouse	NOUN
brj-24041	335	17	exposed	expose	VERB
brj-24041	335	18	to	to	ADP
brj-24041	335	19	chronic	chronic	ADJ
brj-24041	335	20	restraint	restraint	NOUN
brj-24041	335	21	stress	stress	NOUN
brj-24041	335	22	,	,	PUNCT
brj-24041	335	23	”	"	PUNCT
brj-24041	335	24	journal	journal	NOUN
brj-24041	335	25	of	of	ADP
brj-24041	335	26	ethnopharmacology	ethnopharmacology	NOUN
brj-24041	335	27	222	222	NUM
brj-24041	335	28	,	,	PUNCT
brj-24041	335	29	270	270	NUM
brj-24041	335	30	-	-	SYM
brj-24041	335	31	279	279	NUM
brj-24041	335	32	.	.	PUNCT
brj-24041	336	1	doi	doi	NOUN
brj-24041	336	2	:	:	PUNCT
brj-24041	336	3	10.1016	10.1016	NUM
brj-24041	336	4	/	/	SYM
brj-24041	336	5	j.jep.2018.04.010	j.jep.2018.04.010	NOUN
brj-24041	336	6	park	park	NOUN
brj-24041	336	7	,	,	PUNCT
brj-24041	336	8	y.	y.	PROPN
brj-24041	336	9	j.	j.	PROPN
brj-24041	336	10	,	,	PUNCT
brj-24041	336	11	cho	cho	PROPN
brj-24041	336	12	,	,	PUNCT
brj-24041	336	13	y.	y.	PROPN
brj-24041	336	14	r.	r.	PROPN
brj-24041	336	15	,	,	PUNCT
brj-24041	336	16	oh	oh	INTJ
brj-24041	336	17	,	,	PUNCT
brj-24041	336	18	j.	j.	PROPN
brj-24041	336	19	s.	s.	PROPN
brj-24041	336	20	,	,	PUNCT
brj-24041	336	21	and	and	CCONJ
brj-24041	336	22	ahn	ahn	PROPN
brj-24041	336	23	,	,	PUNCT
brj-24041	336	24	e.	e.	PROPN
brj-24041	336	25	k.	k.	PROPN
brj-24041	336	26	(	(	PUNCT
brj-24041	336	27	2017	2017	NUM
brj-24041	336	28	)	)	PUNCT
brj-24041	336	29	.	.	PUNCT
brj-24041	337	1	“	"	PUNCT
brj-24041	337	2	effects	effect	NOUN
brj-24041	337	3	of	of	ADP
brj-24041	337	4	tribulus	tribulus	NOUN
brj-24041	337	5	terrestris	terrestris	PROPN
brj-24041	337	6	on	on	ADP
brj-24041	337	7	monosodium	monosodium	NOUN
brj-24041	337	8	iodoacetate	iodoacetate	ADV
brj-24041	337	9	-	-	PUNCT
brj-24041	337	10	induced	induce	VERB
brj-24041	337	11	osteoarthritis	osteoarthritis	NOUN
brj-24041	337	12	pain	pain	NOUN
brj-24041	337	13	in	in	ADP
brj-24041	337	14	rats	rat	NOUN
brj-24041	337	15	,	,	PUNCT
brj-24041	337	16	”	"	PUNCT
brj-24041	337	17	molecular	molecular	ADJ
brj-24041	337	18	medicine	medicine	NOUN
brj-24041	337	19	reports	report	VERB
brj-24041	337	20	16(4	16(4	NUM
brj-24041	337	21	)	)	PUNCT
brj-24041	337	22	,	,	PUNCT
brj-24041	337	23	5303	5303	NUM
brj-24041	337	24	-	-	SYM
brj-24041	337	25	5311	5311	NUM
brj-24041	337	26	.	.	PUNCT
brj-24041	338	1	doi	doi	NOUN
brj-24041	338	2	:	:	PUNCT
brj-24041	338	3	10.3892	10.3892	NUM
brj-24041	338	4	/	/	SYM
brj-24041	338	5	mmr.2017.7296	mmr.2017.7296	PROPN
brj-24041	338	6	rahman	rahman	PROPN
brj-24041	338	7	,	,	PUNCT
brj-24041	338	8	a.	a.	NOUN
brj-24041	338	9	,	,	PUNCT
brj-24041	338	10	and	and	CCONJ
brj-24041	338	11	fazal	fazal	PROPN
brj-24041	338	12	,	,	PUNCT
brj-24041	338	13	f.	f.	PROPN
brj-24041	338	14	(	(	PUNCT
brj-24041	338	15	2011	2011	NUM
brj-24041	338	16	)	)	PUNCT
brj-24041	338	17	.	.	PUNCT
brj-24041	339	1	“	"	PUNCT
brj-24041	339	2	blocking	block	VERB
brj-24041	339	3	nf	nf	NOUN
brj-24041	339	4	-	-	PUNCT
brj-24041	339	5	kb	kb	NOUN
brj-24041	339	6	:	:	PUNCT
brj-24041	339	7	an	an	DET
brj-24041	339	8	inflammatory	inflammatory	ADJ
brj-24041	339	9	issue	issue	NOUN
brj-24041	339	10	,	,	PUNCT
brj-24041	339	11	”	"	PUNCT
brj-24041	339	12	in	in	ADP
brj-24041	339	13	:	:	PUNCT
brj-24041	339	14	proceedings	proceeding	NOUN
brj-24041	339	15	of	of	ADP
brj-24041	339	16	the	the	DET
brj-24041	339	17	american	american	PROPN
brj-24041	339	18	thoracic	thoracic	NOUN
brj-24041	339	19	society	society	NOUN
brj-24041	339	20	,	,	PUNCT
brj-24041	339	21	pp	pp	ADP
brj-24041	339	22	.	.	PUNCT
brj-24041	340	1	497	497	NUM
brj-24041	340	2	-	-	SYM
brj-24041	340	3	503	503	NUM
brj-24041	340	4	.	.	PUNCT
brj-24041	341	1	doi	doi	NOUN
brj-24041	341	2	:	:	PUNCT
brj-24041	341	3	10.1513	10.1513	NUM
brj-24041	341	4	/	/	SYM
brj-24041	341	5	pats.201101	pats.201101	ADJ
brj-24041	341	6	-	-	PUNCT
brj-24041	341	7	009mw	009mw	NOUN
brj-24041	341	8	rizk	rizk	PROPN
brj-24041	341	9	,	,	PUNCT
brj-24041	341	10	e.	e.	PROPN
brj-24041	341	11	,	,	PUNCT
brj-24041	341	12	tajchman	tajchman	PROPN
brj-24041	341	13	,	,	PUNCT
brj-24041	341	14	s.	s.	PROPN
brj-24041	341	15	,	,	PUNCT
brj-24041	341	16	fink	fink	PROPN
brj-24041	341	17	,	,	PUNCT
brj-24041	341	18	e.	e.	PROPN
brj-24041	341	19	,	,	PUNCT
brj-24041	341	20	aryal	aryal	PROPN
brj-24041	341	21	,	,	PUNCT
brj-24041	341	22	d.	d.	PROPN
brj-24041	341	23	k.	k.	PROPN
brj-24041	341	24	,	,	PUNCT
brj-24041	341	25	iso	iso	PROPN
brj-24041	341	26	,	,	PUNCT
brj-24041	341	27	t.	t.	PROPN
brj-24041	341	28	,	,	PUNCT
brj-24041	341	29	flores	flores	PROPN
brj-24041	341	30	,	,	PUNCT
brj-24041	341	31	e.	e.	PROPN
brj-24041	341	32	,	,	PUNCT
brj-24041	341	33	brown	brown	PROPN
brj-24041	341	34	,	,	PUNCT
brj-24041	341	35	a.	a.	PROPN
brj-24041	341	36	e.	e.	PROPN
brj-24041	341	37	,	,	PUNCT
brj-24041	341	38	chokshi	chokshi	PROPN
brj-24041	341	39	,	,	PUNCT
brj-24041	341	40	s.	s.	PROPN
brj-24041	341	41	p.	p.	PROPN
brj-24041	341	42	,	,	PUNCT
brj-24041	341	43	desai	desai	PROPN
brj-24041	341	44	,	,	PUNCT
brj-24041	341	45	s.	s.	PROPN
brj-24041	341	46	n.	n.	PROPN
brj-24041	341	47	,	,	PUNCT
brj-24041	341	48	dewan	dewan	PROPN
brj-24041	341	49	,	,	PUNCT
brj-24041	341	50	a.	a.	PROPN
brj-24041	341	51	k.	k.	PROPN
brj-24041	341	52	,	,	PUNCT
brj-24041	341	53	kazzaz	kazzaz	PROPN
brj-24041	341	54	,	,	PUNCT
brj-24041	341	55	s.	s.	PROPN
brj-24041	341	56	a.	a.	PROPN
brj-24041	341	57	,	,	PUNCT
brj-24041	341	58	guevara	guevara	PROPN
brj-24041	341	59	,	,	PUNCT
brj-24041	341	60	m.	m.	NOUN
brj-24041	341	61	,	,	PUNCT
brj-24041	341	62	nagaraj	nagaraj	PROPN
brj-24041	341	63	,	,	PUNCT
brj-24041	341	64	s.	s.	PROPN
brj-24041	341	65	,	,	PUNCT
brj-24041	341	66	robben	robben	PROPN
brj-24041	341	67	,	,	PUNCT
brj-24041	341	68	c.	c.	PROPN
brj-24041	341	69	p.	p.	PROPN
brj-24041	341	70	,	,	PUNCT
brj-24041	341	71	vittone	vittone	ADJ
brj-24041	341	72	,	,	PUNCT
brj-24041	341	73	v.	v.	ADV
brj-24041	341	74	,	,	PUNCT
brj-24041	341	75	and	and	CCONJ
brj-24041	341	76	swan	swan	NOUN
brj-24041	341	77	,	,	PUNCT
brj-24041	341	78	j.	j.	PROPN
brj-24041	341	79	t.	t.	PROPN
brj-24041	341	80	(	(	PUNCT
brj-24041	341	81	2023	2023	NUM
brj-24041	341	82	)	)	PUNCT
brj-24041	341	83	.	.	PUNCT
brj-24041	342	1	“	"	PUNCT
brj-24041	342	2	quality	quality	NOUN
brj-24041	342	3	indicators	indicator	NOUN
brj-24041	342	4	for	for	ADP
brj-24041	342	5	osteoarthritis	osteoarthritis	NOUN
brj-24041	342	6	pain	pain	NOUN
brj-24041	342	7	management	management	NOUN
brj-24041	342	8	in	in	ADP
brj-24041	342	9	the	the	DET
brj-24041	342	10	primary	primary	ADJ
brj-24041	342	11	care	care	NOUN
brj-24041	342	12	setting	setting	NOUN
brj-24041	342	13	,	,	PUNCT
brj-24041	342	14	”	"	PUNCT
brj-24041	342	15	bmc	bmc	VERB
brj-24041	342	16	musculoskeletal	musculoskeletal	ADJ
brj-24041	342	17	disorders	disorder	NOUN
brj-24041	342	18	24(1	24(1	NOUN
brj-24041	342	19	)	)	PUNCT
brj-24041	342	20	,	,	PUNCT
brj-24041	342	21	peer	peer	NOUN
brj-24041	342	22	-	-	PUNCT
brj-24041	342	23	reviewed	review	VERB
brj-24041	342	24	article	article	NOUN
brj-24041	342	25	bioresources.cnr.ncsu.edu	bioresources.cnr.ncsu.edu	ADP
brj-24041	342	26	wang	wang	PROPN
brj-24041	342	27	et	et	PROPN
brj-24041	342	28	al	al	PROPN
brj-24041	342	29	.	.	PROPN
brj-24041	343	1	(	(	PUNCT
brj-24041	343	2	2025	2025	NUM
brj-24041	343	3	)	)	PUNCT
brj-24041	343	4	.	.	PUNCT
brj-24041	344	1	“	"	PUNCT
brj-24041	344	2	leaf	leaf	NOUN
brj-24041	344	3	extract	extract	VERB
brj-24041	344	4	anti	anti	ADJ
brj-24041	344	5	-	-	ADJ
brj-24041	344	6	inflammation	inflammation	ADJ
brj-24041	344	7	,	,	PUNCT
brj-24041	344	8	”	"	PUNCT
brj-24041	344	9	bioresources	bioresource	NOUN
brj-24041	344	10	20(1	20(1	NUM
brj-24041	344	11	)	)	PUNCT
brj-24041	344	12	,	,	PUNCT
brj-24041	344	13	956	956	NUM
brj-24041	344	14	-	-	SYM
brj-24041	344	15	971	971	NUM
brj-24041	344	16	.	.	PUNCT
brj-24041	345	1	971	971	NUM
brj-24041	345	2	article	article	NOUN
brj-24041	345	3	538	538	NUM
brj-24041	345	4	.	.	PUNCT
brj-24041	346	1	doi	doi	NOUN
brj-24041	346	2	:	:	PUNCT
brj-24041	346	3	10.1186	10.1186	NUM
brj-24041	346	4	/	/	SYM
brj-24041	346	5	s12891	s12891	NOUN
brj-24041	346	6	-	-	PUNCT
brj-24041	346	7	023	023	NUM
brj-24041	346	8	-	-	PUNCT
brj-24041	346	9	06637	06637	NUM
brj-24041	346	10	-	-	PUNCT
brj-24041	346	11	x	x	SYM
brj-24041	346	12	saito	saito	PROPN
brj-24041	346	13	,	,	PUNCT
brj-24041	346	14	m.	m.	NOUN
brj-24041	346	15	,	,	PUNCT
brj-24041	346	16	mulati	mulati	NOUN
brj-24041	346	17	,	,	PUNCT
brj-24041	346	18	m.	m.	NOUN
brj-24041	346	19	,	,	PUNCT
brj-24041	346	20	talib	talib	PROPN
brj-24041	346	21	,	,	PUNCT
brj-24041	346	22	s.	s.	PROPN
brj-24041	346	23	z.	z.	PROPN
brj-24041	346	24	a.	a.	PROPN
brj-24041	346	25	,	,	PUNCT
brj-24041	346	26	kaldis	kaldis	PROPN
brj-24041	346	27	,	,	PUNCT
brj-24041	346	28	p.	p.	PROPN
brj-24041	346	29	,	,	PUNCT
brj-24041	346	30	takeda	takeda	PROPN
brj-24041	346	31	,	,	PUNCT
brj-24041	346	32	s.	s.	PROPN
brj-24041	346	33	,	,	PUNCT
brj-24041	346	34	okawa	okawa	PROPN
brj-24041	346	35	,	,	PUNCT
brj-24041	346	36	a.	a.	NOUN
brj-24041	346	37	,	,	PUNCT
brj-24041	346	38	and	and	CCONJ
brj-24041	346	39	inose	inose	PROPN
brj-24041	346	40	,	,	PUNCT
brj-24041	346	41	h.	h.	PROPN
brj-24041	346	42	(	(	PUNCT
brj-24041	346	43	2016	2016	NUM
brj-24041	346	44	)	)	PUNCT
brj-24041	346	45	.	.	PUNCT
brj-24041	347	1	“	"	PUNCT
brj-24041	347	2	the	the	DET
brj-24041	347	3	indispensable	indispensable	ADJ
brj-24041	347	4	role	role	NOUN
brj-24041	347	5	of	of	ADP
brj-24041	347	6	cyclin	cyclin	NOUN
brj-24041	347	7	-	-	PUNCT
brj-24041	347	8	dependent	dependent	ADJ
brj-24041	347	9	kinase	kinase	NOUN
brj-24041	347	10	1	1	NUM
brj-24041	347	11	in	in	ADP
brj-24041	347	12	skeletal	skeletal	ADJ
brj-24041	347	13	development	development	NOUN
brj-24041	347	14	,	,	PUNCT
brj-24041	347	15	”	"	PUNCT
brj-24041	347	16	scientific	scientific	ADJ
brj-24041	347	17	reports	report	NOUN
brj-24041	347	18	6	6	NUM
brj-24041	347	19	,	,	PUNCT
brj-24041	347	20	article	article	NOUN
brj-24041	347	21	20622	20622	NUM
brj-24041	347	22	.	.	PUNCT
brj-24041	348	1	doi	doi	NOUN
brj-24041	348	2	:	:	PUNCT
brj-24041	348	3	10.1038	10.1038	NUM
brj-24041	348	4	/	/	SYM
brj-24041	348	5	srep20622	srep20622	PROPN
brj-24041	348	6	scholler	scholler	NOUN
brj-24041	348	7	,	,	PUNCT
brj-24041	348	8	m.	m.	NOUN
brj-24041	348	9	,	,	PUNCT
brj-24041	348	10	and	and	CCONJ
brj-24041	348	11	gams	gams	PROPN
brj-24041	348	12	,	,	PUNCT
brj-24041	348	13	w.	w.	PROPN
brj-24041	348	14	(	(	PUNCT
brj-24041	348	15	1998	1998	NUM
brj-24041	348	16	)	)	PUNCT
brj-24041	348	17	.	.	PUNCT
brj-24041	349	1	“	"	PUNCT
brj-24041	349	2	notes	note	NOUN
brj-24041	349	3	on	on	ADP
brj-24041	349	4	a	a	DET
brj-24041	349	5	powdery	powdery	ADJ
brj-24041	349	6	mildew	mildew	NOUN
brj-24041	349	7	on	on	ADP
brj-24041	349	8	the	the	DET
brj-24041	349	9	ornamental	ornamental	ADJ
brj-24041	349	10	plant	plant	NOUN
brj-24041	349	11	akebia	akebia	PROPN
brj-24041	349	12	quinata	quinata	PROPN
brj-24041	349	13	(	(	PUNCT
brj-24041	349	14	lardizabalaceae	lardizabalaceae	PROPN
brj-24041	349	15	)	)	PUNCT
brj-24041	349	16	,	,	PUNCT
brj-24041	349	17	”	"	PUNCT
brj-24041	349	18	nova	nova	PROPN
brj-24041	349	19	hedwigia	hedwigia	PROPN
brj-24041	349	20	67(1–2	67(1–2	PROPN
brj-24041	349	21	)	)	PUNCT
brj-24041	349	22	,	,	PUNCT
brj-24041	349	23	101	101	NUM
brj-24041	349	24	-	-	SYM
brj-24041	349	25	106	106	NUM
brj-24041	349	26	.	.	PUNCT
brj-24041	350	1	doi	doi	NOUN
brj-24041	350	2	:	:	PUNCT
brj-24041	350	3	10.1127	10.1127	NUM
brj-24041	350	4	/	/	SYM
brj-24041	350	5	nova.hedwigia/67/1998/101	nova.hedwigia/67/1998/101	PROPN
brj-24041	350	6	srivastava	srivastava	PROPN
brj-24041	350	7	,	,	PUNCT
brj-24041	350	8	j.	j.	PROPN
brj-24041	350	9	k.	k.	PROPN
brj-24041	350	10	,	,	PUNCT
brj-24041	350	11	pillai	pillai	PROPN
brj-24041	350	12	,	,	PUNCT
brj-24041	350	13	g.	g.	PROPN
brj-24041	350	14	g.	g.	PROPN
brj-24041	350	15	,	,	PUNCT
brj-24041	350	16	bhat	bhat	PROPN
brj-24041	350	17	,	,	PUNCT
brj-24041	350	18	h.	h.	PROPN
brj-24041	350	19	r.	r.	PROPN
brj-24041	350	20	,	,	PUNCT
brj-24041	350	21	verma	verma	PROPN
brj-24041	350	22	,	,	PUNCT
brj-24041	350	23	a.	a.	NOUN
brj-24041	350	24	,	,	PUNCT
brj-24041	350	25	and	and	CCONJ
brj-24041	350	26	singh	singh	PROPN
brj-24041	350	27	,	,	PUNCT
brj-24041	350	28	u.	u.	PROPN
brj-24041	350	29	p.	p.	PROPN
brj-24041	350	30	(	(	PUNCT
brj-24041	350	31	2017	2017	NUM
brj-24041	350	32	)	)	PUNCT
brj-24041	350	33	.	.	PUNCT
brj-24041	351	1	“	"	PUNCT
brj-24041	351	2	design	design	NOUN
brj-24041	351	3	and	and	CCONJ
brj-24041	351	4	discovery	discovery	NOUN
brj-24041	351	5	of	of	ADP
brj-24041	351	6	novel	novel	ADJ
brj-24041	351	7	monastrol-1,3,5	monastrol-1,3,5	NOUN
brj-24041	351	8	-	-	NOUN
brj-24041	351	9	triazines	triazine	NOUN
brj-24041	351	10	as	as	ADP
brj-24041	351	11	potent	potent	ADJ
brj-24041	351	12	anti	anti	ADJ
brj-24041	351	13	-	-	ADJ
brj-24041	351	14	breast	breast	ADJ
brj-24041	351	15	cancer	cancer	NOUN
brj-24041	351	16	agent	agent	NOUN
brj-24041	351	17	via	via	ADP
brj-24041	351	18	attenuating	attenuate	VERB
brj-24041	351	19	epidermal	epidermal	ADJ
brj-24041	351	20	growth	growth	NOUN
brj-24041	351	21	factor	factor	NOUN
brj-24041	351	22	receptor	receptor	NOUN
brj-24041	351	23	tyrosine	tyrosine	PROPN
brj-24041	351	24	kinase	kinase	PROPN
brj-24041	351	25	,	,	PUNCT
brj-24041	351	26	”	"	PUNCT
brj-24041	351	27	scientific	scientific	ADJ
brj-24041	351	28	reports	report	NOUN
brj-24041	351	29	7(1	7(1	NUM
brj-24041	351	30	)	)	PUNCT
brj-24041	351	31	,	,	PUNCT
brj-24041	351	32	article	article	NOUN
brj-24041	351	33	5851	5851	NUM
brj-24041	351	34	.	.	PUNCT
brj-24041	352	1	doi	doi	NOUN
brj-24041	352	2	:	:	PUNCT
brj-24041	352	3	10.1038	10.1038	NUM
brj-24041	352	4	/	/	SYM
brj-24041	352	5	s41598	s41598	NOUN
brj-24041	352	6	-	-	PUNCT
brj-24041	352	7	017	017	NUM
brj-24041	352	8	-	-	PUNCT
brj-24041	352	9	05934	05934	NUM
brj-24041	352	10	-	-	SYM
brj-24041	352	11	5	5	NUM
brj-24041	352	12	steinmetz	steinmetz	NOUN
brj-24041	352	13	,	,	PUNCT
brj-24041	352	14	j.	j.	PROPN
brj-24041	352	15	d.	d.	PROPN
brj-24041	352	16	,	,	PUNCT
brj-24041	352	17	culbreth	culbreth	PROPN
brj-24041	352	18	,	,	PUNCT
brj-24041	352	19	g.	g.	PROPN
brj-24041	352	20	t.	t.	PROPN
brj-24041	352	21	,	,	PUNCT
brj-24041	352	22	haile	haile	PROPN
brj-24041	352	23	,	,	PUNCT
brj-24041	352	24	l.	l.	PROPN
brj-24041	352	25	m.	m.	PROPN
brj-24041	352	26	,	,	PUNCT
brj-24041	352	27	rafferty	rafferty	PROPN
brj-24041	352	28	,	,	PUNCT
brj-24041	352	29	q.	q.	PROPN
brj-24041	352	30	,	,	PUNCT
brj-24041	352	31	lo	lo	PROPN
brj-24041	352	32	,	,	PUNCT
brj-24041	352	33	j.	j.	PROPN
brj-24041	352	34	,	,	PUNCT
brj-24041	352	35	fukutaki	fukutaki	PROPN
brj-24041	352	36	,	,	PUNCT
brj-24041	352	37	k.	k.	PROPN
brj-24041	352	38	g.	g.	PROPN
brj-24041	352	39	,	,	PUNCT
brj-24041	352	40	cruz	cruz	PROPN
brj-24041	352	41	,	,	PUNCT
brj-24041	352	42	j.	j.	PROPN
brj-24041	352	43	a.	a.	PROPN
brj-24041	352	44	,	,	PUNCT
brj-24041	352	45	smith	smith	PROPN
brj-24041	352	46	,	,	PUNCT
brj-24041	352	47	a.	a.	PROPN
brj-24041	352	48	e.	e.	PROPN
brj-24041	352	49	,	,	PUNCT
brj-24041	352	50	vollset	vollset	PROPN
brj-24041	352	51	,	,	PUNCT
brj-24041	352	52	s.	s.	PROPN
brj-24041	352	53	e.	e.	PROPN
brj-24041	352	54	,	,	PUNCT
brj-24041	352	55	brooks	brooks	PROPN
brj-24041	352	56	,	,	PUNCT
brj-24041	352	57	p.	p.	NOUN
brj-24041	352	58	m.	m.	NOUN
brj-24041	352	59	,	,	PUNCT
brj-24041	352	60	et	et	PROPN
brj-24041	352	61	al	al	PROPN
brj-24041	352	62	.	.	PROPN
brj-24041	353	1	(	(	PUNCT
brj-24041	353	2	2023	2023	NUM
brj-24041	353	3	)	)	PUNCT
brj-24041	353	4	.	.	PUNCT
brj-24041	354	1	“	"	PUNCT
brj-24041	354	2	global	global	ADJ
brj-24041	354	3	,	,	PUNCT
brj-24041	354	4	regional	regional	ADJ
brj-24041	354	5	,	,	PUNCT
brj-24041	354	6	and	and	CCONJ
brj-24041	354	7	national	national	ADJ
brj-24041	354	8	burden	burden	NOUN
brj-24041	354	9	of	of	ADP
brj-24041	354	10	osteoarthritis	osteoarthritis	NOUN
brj-24041	354	11	,	,	PUNCT
brj-24041	354	12	1990	1990	NUM
brj-24041	354	13	-	-	SYM
brj-24041	354	14	2020	2020	NUM
brj-24041	354	15	and	and	CCONJ
brj-24041	354	16	projections	projection	NOUN
brj-24041	354	17	to	to	ADP
brj-24041	354	18	2050	2050	NUM
brj-24041	354	19	:	:	PUNCT
brj-24041	354	20	a	a	DET
brj-24041	354	21	systematic	systematic	ADJ
brj-24041	354	22	analysis	analysis	NOUN
brj-24041	354	23	for	for	ADP
brj-24041	354	24	the	the	DET
brj-24041	354	25	global	global	ADJ
brj-24041	354	26	burden	burden	NOUN
brj-24041	354	27	of	of	ADP
brj-24041	354	28	disease	disease	NOUN
brj-24041	354	29	study	study	NOUN
brj-24041	354	30	2021	2021	NUM
brj-24041	354	31	,	,	PUNCT
brj-24041	354	32	”	"	PUNCT
brj-24041	354	33	the	the	DET
brj-24041	354	34	lancet	lancet	PROPN
brj-24041	354	35	rheumatology	rheumatology	NOUN
brj-24041	354	36	5(9	5(9	NUM
brj-24041	354	37	)	)	PUNCT
brj-24041	354	38	,	,	PUNCT
brj-24041	354	39	e508	e508	PROPN
brj-24041	354	40	-	-	PUNCT
brj-24041	354	41	e522	e522	PROPN
brj-24041	354	42	.	.	PUNCT
brj-24041	355	1	doi	doi	NOUN
brj-24041	355	2	:	:	PUNCT
brj-24041	355	3	10.1016	10.1016	NUM
brj-24041	355	4	/	/	SYM
brj-24041	355	5	s2665	s2665	NUM
brj-24041	355	6	-	-	PUNCT
brj-24041	355	7	9913(23)00163	9913(23)00163	NUM
brj-24041	355	8	-	-	SYM
brj-24041	355	9	7	7	NUM
brj-24041	355	10	sun	sun	NOUN
brj-24041	355	11	,	,	PUNCT
brj-24041	355	12	g.	g.	PROPN
brj-24041	355	13	,	,	PUNCT
brj-24041	355	14	ba	ba	PROPN
brj-24041	355	15	,	,	PUNCT
brj-24041	355	16	c.	c.	PROPN
brj-24041	355	17	l.	l.	PROPN
brj-24041	355	18	,	,	PUNCT
brj-24041	355	19	gao	gao	PROPN
brj-24041	355	20	,	,	PUNCT
brj-24041	355	21	r.	r.	PROPN
brj-24041	355	22	,	,	PUNCT
brj-24041	355	23	liu	liu	PROPN
brj-24041	355	24	,	,	PUNCT
brj-24041	355	25	w.	w.	PROPN
brj-24041	355	26	,	,	PUNCT
brj-24041	355	27	and	and	CCONJ
brj-24041	355	28	ji	ji	PROPN
brj-24041	355	29	,	,	PUNCT
brj-24041	355	30	q.	q.	PROPN
brj-24041	355	31	(	(	PUNCT
brj-24041	355	32	2019a	2019a	NUM
brj-24041	355	33	)	)	PUNCT
brj-24041	355	34	.	.	PUNCT
brj-24041	356	1	“	"	PUNCT
brj-24041	356	2	association	association	NOUN
brj-24041	356	3	of	of	ADP
brj-24041	356	4	il-6	il-6	NOUN
brj-24041	356	5	,	,	PUNCT
brj-24041	356	6	il-8	il-8	NOUN
brj-24041	356	7	,	,	PUNCT
brj-24041	356	8	mmp-13	mmp-13	VERB
brj-24041	356	9	gene	gene	NOUN
brj-24041	356	10	polymorphisms	polymorphism	NOUN
brj-24041	356	11	with	with	ADP
brj-24041	356	12	knee	knee	NOUN
brj-24041	356	13	osteoarthritis	osteoarthritis	NOUN
brj-24041	356	14	susceptibility	susceptibility	NOUN
brj-24041	356	15	in	in	ADP
brj-24041	356	16	the	the	DET
brj-24041	356	17	chinese	chinese	ADJ
brj-24041	356	18	han	han	PROPN
brj-24041	356	19	population	population	PROPN
brj-24041	356	20	,	,	PUNCT
brj-24041	356	21	”	"	PUNCT
brj-24041	356	22	bioscience	bioscience	NOUN
brj-24041	356	23	reports	report	VERB
brj-24041	356	24	39(2	39(2	NUM
brj-24041	356	25	)	)	PUNCT
brj-24041	356	26	,	,	PUNCT
brj-24041	356	27	article	article	NOUN
brj-24041	356	28	bsr20181346	bsr20181346	VERB
brj-24041	356	29	.	.	PUNCT
brj-24041	357	1	doi	doi	NOUN
brj-24041	357	2	:	:	PUNCT
brj-24041	357	3	10.1042	10.1042	NUM
brj-24041	357	4	/	/	SYM
brj-24041	357	5	bsr20181346	bsr20181346	ADJ
brj-24041	357	6	sun	sun	NOUN
brj-24041	357	7	,	,	PUNCT
brj-24041	357	8	x.	x.	PROPN
brj-24041	357	9	,	,	PUNCT
brj-24041	357	10	zhen	zhen	PROPN
brj-24041	357	11	,	,	PUNCT
brj-24041	357	12	x.	x.	PROPN
brj-24041	357	13	,	,	PUNCT
brj-24041	357	14	hu	hu	PROPN
brj-24041	357	15	,	,	PUNCT
brj-24041	357	16	x.	x.	PROPN
brj-24041	357	17	,	,	PUNCT
brj-24041	357	18	li	li	PROPN
brj-24041	357	19	,	,	PUNCT
brj-24041	357	20	y.	y.	PROPN
brj-24041	357	21	,	,	PUNCT
brj-24041	357	22	gu	gu	PROPN
brj-24041	357	23	,	,	PUNCT
brj-24041	357	24	s.	s.	PROPN
brj-24041	357	25	,	,	PUNCT
brj-24041	357	26	gu	gu	PROPN
brj-24041	357	27	,	,	PUNCT
brj-24041	357	28	y.	y.	NOUN
brj-24041	357	29	,	,	PUNCT
brj-24041	357	30	and	and	CCONJ
brj-24041	357	31	dong	dong	PROPN
brj-24041	357	32	,	,	PUNCT
brj-24041	357	33	h.	h.	PROPN
brj-24041	357	34	(	(	PUNCT
brj-24041	357	35	2019b	2019b	NUM
brj-24041	357	36	)	)	PUNCT
brj-24041	357	37	.	.	PUNCT
brj-24041	358	1	“	"	PUNCT
brj-24041	358	2	osteoarthritis	osteoarthritis	NOUN
brj-24041	358	3	in	in	ADP
brj-24041	358	4	the	the	DET
brj-24041	358	5	middle	middle	NOUN
brj-24041	358	6	-	-	PUNCT
brj-24041	358	7	aged	aged	ADJ
brj-24041	358	8	and	and	CCONJ
brj-24041	358	9	elderly	elderly	ADJ
brj-24041	358	10	in	in	ADP
brj-24041	358	11	china	china	PROPN
brj-24041	358	12	:	:	PUNCT
brj-24041	358	13	prevalence	prevalence	NOUN
brj-24041	358	14	and	and	CCONJ
brj-24041	358	15	influencing	influence	VERB
brj-24041	358	16	factors	factor	NOUN
brj-24041	358	17	,	,	PUNCT
brj-24041	358	18	”	"	PUNCT
brj-24041	358	19	international	international	ADJ
brj-24041	358	20	journal	journal	NOUN
brj-24041	358	21	of	of	ADP
brj-24041	358	22	environmental	environmental	ADJ
brj-24041	358	23	research	research	NOUN
brj-24041	358	24	and	and	CCONJ
brj-24041	358	25	public	public	ADJ
brj-24041	358	26	health	health	NOUN
brj-24041	358	27	16(23	16(23	NOUN
brj-24041	358	28	)	)	PUNCT
brj-24041	358	29	,	,	PUNCT
brj-24041	358	30	article	article	NOUN
brj-24041	358	31	4701	4701	NUM
brj-24041	358	32	.	.	PUNCT
brj-24041	359	1	doi	doi	NOUN
brj-24041	359	2	:	:	PUNCT
brj-24041	359	3	10.3390	10.3390	NUM
brj-24041	359	4	/	/	SYM
brj-24041	359	5	ijerph16234701	ijerph16234701	PROPN
brj-24041	359	6	tan	tan	PROPN
brj-24041	359	7	,	,	PUNCT
brj-24041	359	8	c.	c.	PROPN
brj-24041	359	9	,	,	PUNCT
brj-24041	359	10	zhang	zhang	PROPN
brj-24041	359	11	,	,	PUNCT
brj-24041	359	12	j.	j.	PROPN
brj-24041	359	13	,	,	PUNCT
brj-24041	359	14	chen	chen	PROPN
brj-24041	359	15	,	,	PUNCT
brj-24041	359	16	w.	w.	PROPN
brj-24041	359	17	,	,	PUNCT
brj-24041	359	18	feng	feng	PROPN
brj-24041	359	19	,	,	PUNCT
brj-24041	359	20	f.	f.	PROPN
brj-24041	359	21	,	,	PUNCT
brj-24041	359	22	yu	yu	PROPN
brj-24041	359	23	,	,	PUNCT
brj-24041	359	24	c.	c.	PROPN
brj-24041	359	25	,	,	PUNCT
brj-24041	359	26	lu	lu	PROPN
brj-24041	359	27	,	,	PUNCT
brj-24041	359	28	x.	x.	PROPN
brj-24041	359	29	,	,	PUNCT
brj-24041	359	30	lin	lin	PROPN
brj-24041	359	31	,	,	PUNCT
brj-24041	359	32	r.	r.	PROPN
brj-24041	359	33	,	,	PUNCT
brj-24041	359	34	li	li	PROPN
brj-24041	359	35	,	,	PUNCT
brj-24041	359	36	z.	z.	PROPN
brj-24041	359	37	,	,	PUNCT
brj-24041	359	38	huang	huang	PROPN
brj-24041	359	39	,	,	PUNCT
brj-24041	359	40	y.	y.	PROPN
brj-24041	359	41	,	,	PUNCT
brj-24041	359	42	zheng	zheng	PROPN
brj-24041	359	43	,	,	PUNCT
brj-24041	359	44	l.	l.	PROPN
brj-24041	359	45	,	,	PUNCT
brj-24041	359	46	huang	huang	PROPN
brj-24041	359	47	,	,	PUNCT
brj-24041	359	48	m.	m.	NOUN
brj-24041	359	49	,	,	PUNCT
brj-24041	359	50	and	and	CCONJ
brj-24041	359	51	wu	wu	PROPN
brj-24041	359	52	,	,	PUNCT
brj-24041	359	53	g.	g.	PROPN
brj-24041	359	54	(	(	PUNCT
brj-24041	359	55	2019	2019	NUM
brj-24041	359	56	)	)	PUNCT
brj-24041	359	57	.	.	PUNCT
brj-24041	360	1	“	"	PUNCT
brj-24041	360	2	inflammatory	inflammatory	ADJ
brj-24041	360	3	cytokines	cytokine	NOUN
brj-24041	360	4	via	via	ADP
brj-24041	360	5	up	up	ADP
brj-24041	360	6	-	-	PUNCT
brj-24041	360	7	regulation	regulation	NOUN
brj-24041	360	8	of	of	ADP
brj-24041	360	9	aquaporins	aquaporin	NOUN
brj-24041	360	10	deteriorated	deteriorate	VERB
brj-24041	360	11	the	the	DET
brj-24041	360	12	pathogenesis	pathogenesis	NOUN
brj-24041	360	13	of	of	ADP
brj-24041	360	14	early	early	ADJ
brj-24041	360	15	osteoarthritis	osteoarthritis	NOUN
brj-24041	360	16	,	,	PUNCT
brj-24041	360	17	”	"	PUNCT
brj-24041	360	18	plos	plos	PROPN
brj-24041	360	19	one	one	NUM
brj-24041	360	20	14(8	14(8	NUM
brj-24041	360	21	)	)	PUNCT
brj-24041	360	22	,	,	PUNCT
brj-24041	360	23	article	article	NOUN
brj-24041	360	24	eo220846	eo220846	PROPN
brj-24041	360	25	.	.	PUNCT
brj-24041	361	1	doi	doi	NOUN
brj-24041	361	2	:	:	PUNCT
brj-24041	361	3	10.1371	10.1371	NUM
brj-24041	361	4	/	/	SYM
brj-24041	361	5	journal.pone.0220846	journal.pone.0220846	NOUN
brj-24041	361	6	thudium	thudium	NOUN
brj-24041	361	7	,	,	PUNCT
brj-24041	361	8	c.	c.	PROPN
brj-24041	361	9	s.	s.	PROPN
brj-24041	361	10	,	,	PUNCT
brj-24041	361	11	löfvall	löfvall	PROPN
brj-24041	361	12	,	,	PUNCT
brj-24041	361	13	h.	h.	PROPN
brj-24041	361	14	,	,	PUNCT
brj-24041	361	15	karsdal	karsdal	ADJ
brj-24041	361	16	,	,	PUNCT
brj-24041	361	17	m.	m.	NOUN
brj-24041	361	18	a.	a.	PROPN
brj-24041	361	19	,	,	PUNCT
brj-24041	361	20	bay	bay	PROPN
brj-24041	361	21	-	-	PUNCT
brj-24041	361	22	jensen	jensen	PROPN
brj-24041	361	23	,	,	PUNCT
brj-24041	361	24	a.	a.	PROPN
brj-24041	361	25	c.	c.	PROPN
brj-24041	361	26	,	,	PUNCT
brj-24041	361	27	and	and	CCONJ
brj-24041	361	28	bihlet	bihlet	PROPN
brj-24041	361	29	,	,	PUNCT
brj-24041	361	30	a.	a.	PROPN
brj-24041	361	31	r.	r.	PROPN
brj-24041	361	32	(	(	PUNCT
brj-24041	361	33	2019	2019	NUM
brj-24041	361	34	)	)	PUNCT
brj-24041	361	35	.	.	PUNCT
brj-24041	362	1	“	"	PUNCT
brj-24041	362	2	protein	protein	NOUN
brj-24041	362	3	biomarkers	biomarker	NOUN
brj-24041	362	4	associated	associate	VERB
brj-24041	362	5	with	with	ADP
brj-24041	362	6	pain	pain	NOUN
brj-24041	362	7	mechanisms	mechanism	NOUN
brj-24041	362	8	in	in	ADP
brj-24041	362	9	osteoarthritis	osteoarthritis	NOUN
brj-24041	362	10	,	,	PUNCT
brj-24041	362	11	”	"	PUNCT
brj-24041	362	12	journal	journal	NOUN
brj-24041	362	13	of	of	ADP
brj-24041	362	14	proteomics	proteomic	NOUN
brj-24041	362	15	190	190	NUM
brj-24041	362	16	,	,	PUNCT
brj-24041	362	17	55	55	NUM
brj-24041	362	18	-	-	SYM
brj-24041	362	19	66	66	NUM
brj-24041	362	20	.	.	PUNCT
brj-24041	363	1	doi	doi	NOUN
brj-24041	363	2	:	:	PUNCT
brj-24041	363	3	10.1016	10.1016	NUM
brj-24041	363	4	/	/	SYM
brj-24041	363	5	j.jprot.2018.04.030	j.jprot.2018.04.030	PROPN
brj-24041	363	6	verma	verma	PROPN
brj-24041	363	7	,	,	PUNCT
brj-24041	363	8	v.	v.	PROPN
brj-24041	363	9	(	(	PUNCT
brj-24041	363	10	2023	2023	NUM
brj-24041	363	11	)	)	PUNCT
brj-24041	363	12	.	.	PUNCT
brj-24041	364	1	“	"	PUNCT
brj-24041	364	2	the	the	DET
brj-24041	364	3	herbal	herbal	ADJ
brj-24041	364	4	treatment	treatment	NOUN
brj-24041	364	5	of	of	ADP
brj-24041	364	6	osteoarthritis	osteoarthritis	NOUN
brj-24041	364	7	,	,	PUNCT
brj-24041	364	8	”	"	PUNCT
brj-24041	364	9	current	current	ADJ
brj-24041	364	10	traditional	traditional	ADJ
brj-24041	364	11	medicine	medicine	NOUN
brj-24041	364	12	,	,	PUNCT
brj-24041	364	13	10(2	10(2	NUM
brj-24041	364	14	)	)	PUNCT
brj-24041	364	15	,	,	PUNCT
brj-24041	364	16	article	article	NOUN
brj-24041	364	17	e080323214447	e080323214447	PROPN
brj-24041	364	18	.	.	PUNCT
brj-24041	365	1	doi	doi	PROPN
brj-24041	365	2	:	:	PUNCT
brj-24041	365	3	10.2174/2215083809666230308093244	10.2174/2215083809666230308093244	NUM
brj-24041	365	4	wood	wood	NOUN
brj-24041	365	5	,	,	PUNCT
brj-24041	365	6	m.	m.	NOUN
brj-24041	365	7	j.	j.	PROPN
brj-24041	365	8	,	,	PUNCT
brj-24041	365	9	miller	miller	PROPN
brj-24041	365	10	,	,	PUNCT
brj-24041	365	11	r.	r.	PROPN
brj-24041	365	12	e.	e.	PROPN
brj-24041	365	13	,	,	PUNCT
brj-24041	365	14	and	and	CCONJ
brj-24041	365	15	malfait	malfait	ADJ
brj-24041	365	16	,	,	PUNCT
brj-24041	365	17	a.	a.	NOUN
brj-24041	365	18	m.	m.	NOUN
brj-24041	365	19	(	(	PUNCT
brj-24041	365	20	2022	2022	NUM
brj-24041	365	21	)	)	PUNCT
brj-24041	365	22	.	.	PUNCT
brj-24041	366	1	“	"	PUNCT
brj-24041	366	2	the	the	DET
brj-24041	366	3	genesis	genesis	NOUN
brj-24041	366	4	of	of	ADP
brj-24041	366	5	pain	pain	NOUN
brj-24041	366	6	in	in	ADP
brj-24041	366	7	osteoarthritis	osteoarthritis	NOUN
brj-24041	366	8	:	:	PUNCT
brj-24041	366	9	inflammation	inflammation	NOUN
brj-24041	366	10	as	as	ADP
brj-24041	366	11	a	a	DET
brj-24041	366	12	mediator	mediator	NOUN
brj-24041	366	13	of	of	ADP
brj-24041	366	14	osteoarthritis	osteoarthritis	NOUN
brj-24041	366	15	pain	pain	NOUN
brj-24041	366	16	,	,	PUNCT
brj-24041	366	17	”	"	PUNCT
brj-24041	366	18	clinics	clinic	NOUN
brj-24041	366	19	in	in	ADP
brj-24041	366	20	geriatric	geriatric	ADJ
brj-24041	366	21	medicine	medicine	NOUN
brj-24041	366	22	38(2	38(2	NUM
brj-24041	366	23	)	)	PUNCT
brj-24041	366	24	,	,	PUNCT
brj-24041	366	25	221	221	NUM
brj-24041	366	26	-	-	SYM
brj-24041	366	27	238	238	NUM
brj-24041	366	28	.	.	PUNCT
brj-24041	367	1	doi	doi	NOUN
brj-24041	367	2	:	:	PUNCT
brj-24041	367	3	10.1016	10.1016	NUM
brj-24041	367	4	/	/	SYM
brj-24041	367	5	j.cger.2021.11.013	j.cger.2021.11.013	PROPN
brj-24041	367	6	zhang	zhang	PROPN
brj-24041	367	7	,	,	PUNCT
brj-24041	367	8	y.	y.	PROPN
brj-24041	367	9	,	,	PUNCT
brj-24041	367	10	he	he	PRON
brj-24041	367	11	,	,	PUNCT
brj-24041	367	12	l.	l.	PROPN
brj-24041	367	13	,	,	PUNCT
brj-24041	367	14	yang	yang	PROPN
brj-24041	367	15	,	,	PUNCT
brj-24041	367	16	y.	y.	PROPN
brj-24041	367	17	,	,	PUNCT
brj-24041	367	18	cao	cao	PROPN
brj-24041	367	19	,	,	PUNCT
brj-24041	367	20	j.	j.	PROPN
brj-24041	367	21	,	,	PUNCT
brj-24041	367	22	su	su	PROPN
brj-24041	367	23	,	,	PUNCT
brj-24041	367	24	z.	z.	PROPN
brj-24041	367	25	,	,	PUNCT
brj-24041	367	26	zhang	zhang	PROPN
brj-24041	367	27	,	,	PUNCT
brj-24041	367	28	b.	b.	PROPN
brj-24041	367	29	,	,	PUNCT
brj-24041	367	30	guo	guo	PROPN
brj-24041	367	31	,	,	PUNCT
brj-24041	367	32	h.	h.	PROPN
brj-24041	367	33	,	,	PUNCT
brj-24041	367	34	wang	wang	PROPN
brj-24041	367	35	,	,	PUNCT
brj-24041	367	36	z.	z.	PROPN
brj-24041	367	37	,	,	PUNCT
brj-24041	367	38	zhang	zhang	PROPN
brj-24041	367	39	,	,	PUNCT
brj-24041	367	40	p.	p.	PROPN
brj-24041	367	41	,	,	PUNCT
brj-24041	367	42	xie	xie	PROPN
brj-24041	367	43	,	,	PUNCT
brj-24041	367	44	j.	j.	PROPN
brj-24041	367	45	,	,	PUNCT
brj-24041	367	46	li	li	PROPN
brj-24041	367	47	,	,	PUNCT
brj-24041	367	48	j.	j.	PROPN
brj-24041	367	49	,	,	PUNCT
brj-24041	367	50	ye	ye	PROPN
brj-24041	367	51	,	,	PUNCT
brj-24041	367	52	j.	j.	PROPN
brj-24041	367	53	,	,	PUNCT
brj-24041	367	54	zha	zha	PROPN
brj-24041	367	55	,	,	PUNCT
brj-24041	367	56	z.	z.	PROPN
brj-24041	367	57	,	,	PUNCT
brj-24041	367	58	yu	yu	PROPN
brj-24041	367	59	,	,	PUNCT
brj-24041	367	60	h.	h.	PROPN
brj-24041	367	61	,	,	PUNCT
brj-24041	367	62	hong	hong	PROPN
brj-24041	367	63	,	,	PUNCT
brj-24041	367	64	a.	a.	NOUN
brj-24041	367	65	,	,	PUNCT
brj-24041	367	66	and	and	CCONJ
brj-24041	367	67	chen	chen	PROPN
brj-24041	367	68	,	,	PUNCT
brj-24041	367	69	x.	x.	NOUN
brj-24041	367	70	(	(	PUNCT
brj-24041	367	71	2023	2023	NUM
brj-24041	367	72	)	)	PUNCT
brj-24041	367	73	.	.	PUNCT
brj-24041	368	1	“	"	PUNCT
brj-24041	368	2	triclocarban	triclocarban	ADJ
brj-24041	368	3	triggers	trigger	NOUN
brj-24041	368	4	osteoarthritis	osteoarthritis	NOUN
brj-24041	368	5	via	via	ADP
brj-24041	368	6	dnmt1	dnmt1	PROPN
brj-24041	368	7	-	-	PUNCT
brj-24041	368	8	mediated	mediate	VERB
brj-24041	368	9	epigenetic	epigenetic	ADJ
brj-24041	368	10	modification	modification	NOUN
brj-24041	368	11	and	and	CCONJ
brj-24041	368	12	suppression	suppression	NOUN
brj-24041	368	13	of	of	ADP
brj-24041	368	14	col2a	col2a	NOUN
brj-24041	368	15	in	in	ADP
brj-24041	368	16	cartilage	cartilage	NOUN
brj-24041	368	17	tissues	tissue	NOUN
brj-24041	368	18	,	,	PUNCT
brj-24041	368	19	”	"	PUNCT
brj-24041	368	20	journal	journal	NOUN
brj-24041	368	21	of	of	ADP
brj-24041	368	22	hazardous	hazardous	ADJ
brj-24041	368	23	materials	material	NOUN
brj-24041	368	24	447	447	NUM
brj-24041	368	25	,	,	PUNCT
brj-24041	368	26	article	article	NOUN
brj-24041	368	27	130747	130747	NUM
brj-24041	368	28	.	.	PUNCT
brj-24041	369	1	doi	doi	NOUN
brj-24041	369	2	:	:	PUNCT
brj-24041	369	3	10.1016	10.1016	NUM
brj-24041	369	4	/	/	SYM
brj-24041	369	5	j.jhazmat.2023.130747	j.jhazmat.2023.130747	PROPN
brj-24041	369	6	article	article	NOUN
brj-24041	369	7	submitted	submit	VERB
brj-24041	369	8	:	:	PUNCT
brj-24041	369	9	september	september	PROPN
brj-24041	369	10	29	29	NUM
brj-24041	369	11	,	,	PUNCT
brj-24041	369	12	2024	2024	NUM
brj-24041	369	13	;	;	PUNCT
brj-24041	369	14	peer	peer	NOUN
brj-24041	369	15	review	review	NOUN
brj-24041	369	16	completed	complete	VERB
brj-24041	369	17	:	:	PUNCT
brj-24041	369	18	october	october	PROPN
brj-24041	369	19	20	20	NUM
brj-24041	369	20	,	,	PUNCT
brj-24041	369	21	2024	2024	NUM
brj-24041	369	22	;	;	PUNCT
brj-24041	369	23	revised	revise	VERB
brj-24041	369	24	version	version	NOUN
brj-24041	369	25	received	receive	VERB
brj-24041	369	26	and	and	CCONJ
brj-24041	369	27	accepted	accept	VERB
brj-24041	369	28	:	:	PUNCT
brj-24041	369	29	november	november	PROPN
brj-24041	369	30	9	9	NUM
brj-24041	369	31	,	,	PUNCT
brj-24041	369	32	2024	2024	NUM
brj-24041	369	33	;	;	PUNCT
brj-24041	369	34	published	publish	VERB
brj-24041	369	35	:	:	PUNCT
brj-24041	369	36	december	december	PROPN
brj-24041	369	37	2	2	NUM
brj-24041	369	38	,	,	PUNCT
brj-24041	369	39	2024	2024	NUM
brj-24041	369	40	.	.	PUNCT
brj-24041	370	1	doi	doi	NOUN
brj-24041	370	2	:	:	PUNCT
brj-24041	370	3	10.15376	10.15376	NUM
brj-24041	370	4	/	/	SYM
brj-24041	370	5	biores.20.1.956	biores.20.1.956	NUM
brj-24041	370	6	-	-	SYM
brj-24041	370	7	971	971	NUM