id	sid	tid	token	lemma	pos
brainmatters-1090	1	1	brain	brain	NOUN
brainmatters-1090	1	2	matters	matter	NOUN
brainmatters-1090	1	3	vol	vol	NOUN
brainmatters-1090	1	4	.	.	PROPN
brainmatters-1090	1	5	8	8	NUM
brainmatters-1090	2	1	no	no	NOUN
brainmatters-1090	2	2	.	.	NOUN
brainmatters-1090	2	3	2	2	NUM
brainmatters-1090	2	4	written	write	VERB
brainmatters-1090	2	5	by	by	ADP
brainmatters-1090	2	6	emily	emily	PROPN
brainmatters-1090	2	7	aldrich	aldrich	PROPN
brainmatters-1090	2	8	the	the	DET
brainmatters-1090	2	9	detrimental	detrimental	ADJ
brainmatters-1090	2	10	effects	effect	NOUN
brainmatters-1090	2	11	of	of	ADP
brainmatters-1090	2	12	aberrant	aberrant	ADJ
brainmatters-1090	2	13	regulation	regulation	NOUN
brainmatters-1090	2	14	on	on	ADP
brainmatters-1090	2	15	the	the	DET
brainmatters-1090	2	16	hedgehog	hedgehog	NOUN
brainmatters-1090	2	17	signaling	signal	VERB
brainmatters-1090	2	18	pathway	pathway	NOUN
brainmatters-1090	2	19	...	...	PUNCT
brainmatters-1090	2	20	the	the	DET
brainmatters-1090	2	21	dysregulation	dysregulation	NOUN
brainmatters-1090	2	22	of	of	ADP
brainmatters-1090	2	23	the	the	DET
brainmatters-1090	2	24	hh	hh	PROPN
brainmatters-1090	2	25	signaling	signal	VERB
brainmatters-1090	2	26	pathway	pathway	NOUN
brainmatters-1090	2	27	may	may	AUX
brainmatters-1090	2	28	lead	lead	VERB
brainmatters-1090	2	29	to	to	ADP
brainmatters-1090	2	30	a	a	DET
brainmatters-1090	2	31	variety	variety	NOUN
brainmatters-1090	2	32	of	of	ADP
brainmatters-1090	2	33	diseases	disease	NOUN
brainmatters-1090	2	34	and	and	CCONJ
brainmatters-1090	2	35	disorders	disorder	NOUN
brainmatters-1090	2	36	,	,	PUNCT
brainmatters-1090	2	37	including	include	VERB
brainmatters-1090	2	38	tumorigenesis	tumorigenesis	NOUN
brainmatters-1090	2	39	of	of	ADP
brainmatters-1090	2	40	medulloblastoma	medulloblastoma	NOUN
brainmatters-1090	2	41	,	,	PUNCT
brainmatters-1090	2	42	the	the	DET
brainmatters-1090	2	43	most	most	ADV
brainmatters-1090	2	44	common	common	ADJ
brainmatters-1090	2	45	malignant	malignant	ADJ
brainmatters-1090	2	46	brain	brain	NOUN
brainmatters-1090	2	47	tumor	tumor	NOUN
brainmatters-1090	2	48	.	.	PUNCT
brainmatters-1090	3	1	what	what	PRON
brainmatters-1090	3	2	is	be	AUX
brainmatters-1090	3	3	sonic	sonic	ADJ
brainmatters-1090	3	4	hedgehog	hedgehog	NOUN
brainmatters-1090	3	5	?	?	PUNCT
brainmatters-1090	4	1	the	the	DET
brainmatters-1090	4	2	hedgehog	hedgehog	PROPN
brainmatters-1090	4	3	(	(	PUNCT
brainmatters-1090	4	4	hh	hh	PROPN
brainmatters-1090	4	5	)	)	PUNCT
brainmatters-1090	4	6	signaling	signal	VERB
brainmatters-1090	4	7	pathway	pathway	NOUN
brainmatters-1090	4	8	is	be	AUX
brainmatters-1090	4	9	a	a	DET
brainmatters-1090	4	10	conserved	conserved	ADJ
brainmatters-1090	4	11	neural	neural	ADJ
brainmatters-1090	4	12	pathway	pathway	NOUN
brainmatters-1090	4	13	that	that	PRON
brainmatters-1090	4	14	plays	play	VERB
brainmatters-1090	4	15	an	an	DET
brainmatters-1090	4	16	important	important	ADJ
brainmatters-1090	4	17	role	role	NOUN
brainmatters-1090	4	18	in	in	ADP
brainmatters-1090	4	19	the	the	DET
brainmatters-1090	4	20	embryonic	embryonic	ADJ
brainmatters-1090	4	21	development	development	NOUN
brainmatters-1090	4	22	of	of	ADP
brainmatters-1090	4	23	both	both	DET
brainmatters-1090	4	24	invertebrates	invertebrate	NOUN
brainmatters-1090	4	25	and	and	CCONJ
brainmatters-1090	4	26	vertebrates	vertebrate	NOUN
brainmatters-1090	4	27	.	.	PUNCT
brainmatters-1090	5	1	this	this	DET
brainmatters-1090	5	2	pathway	pathway	NOUN
brainmatters-1090	5	3	was	be	AUX
brainmatters-1090	5	4	originally	originally	ADV
brainmatters-1090	5	5	discovered	discover	VERB
brainmatters-1090	5	6	in	in	ADP
brainmatters-1090	5	7	the	the	DET
brainmatters-1090	5	8	species	species	NOUN
brainmatters-1090	5	9	drosophila	drosophila	NOUN
brainmatters-1090	5	10	melanogaster	melanogaster	NOUN
brainmatters-1090	5	11	,	,	PUNCT
brainmatters-1090	5	12	the	the	DET
brainmatters-1090	5	13	common	common	ADJ
brainmatters-1090	5	14	fruit	fruit	NOUN
brainmatters-1090	5	15	fly	fly	NOUN
brainmatters-1090	5	16	,	,	PUNCT
brainmatters-1090	5	17	and	and	CCONJ
brainmatters-1090	5	18	is	be	AUX
brainmatters-1090	5	19	found	find	VERB
brainmatters-1090	5	20	among	among	ADP
brainmatters-1090	5	21	a	a	DET
brainmatters-1090	5	22	variety	variety	NOUN
brainmatters-1090	5	23	of	of	ADP
brainmatters-1090	5	24	species	specie	NOUN
brainmatters-1090	5	25	.	.	PUNCT
brainmatters-1090	6	1	the	the	DET
brainmatters-1090	6	2	signal	signal	ADJ
brainmatters-1090	6	3	transmission	transmission	NOUN
brainmatters-1090	6	4	from	from	ADP
brainmatters-1090	6	5	cell	cell	NOUN
brainmatters-1090	6	6	membranes	membrane	NOUN
brainmatters-1090	6	7	are	be	AUX
brainmatters-1090	6	8	regulated	regulate	VERB
brainmatters-1090	6	9	by	by	ADP
brainmatters-1090	6	10	the	the	DET
brainmatters-1090	6	11	hh	hh	PROPN
brainmatters-1090	6	12	signaling	signal	VERB
brainmatters-1090	6	13	pathway	pathway	NOUN
brainmatters-1090	6	14	and	and	CCONJ
brainmatters-1090	6	15	dictate	dictate	VERB
brainmatters-1090	6	16	embryonic	embryonic	ADJ
brainmatters-1090	6	17	development	development	NOUN
brainmatters-1090	6	18	.	.	PUNCT
brainmatters-1090	7	1	there	there	PRON
brainmatters-1090	7	2	are	be	VERB
brainmatters-1090	7	3	three	three	NUM
brainmatters-1090	7	4	main	main	ADJ
brainmatters-1090	7	5	hedgehog	hedgehog	NOUN
brainmatters-1090	7	6	ligand	ligand	ADJ
brainmatters-1090	7	7	proteins	protein	NOUN
brainmatters-1090	7	8	that	that	PRON
brainmatters-1090	7	9	regulate	regulate	VERB
brainmatters-1090	7	10	the	the	DET
brainmatters-1090	7	11	transcription	transcription	NOUN
brainmatters-1090	7	12	of	of	ADP
brainmatters-1090	7	13	target	target	NOUN
brainmatters-1090	7	14	genes	gene	NOUN
brainmatters-1090	7	15	for	for	ADP
brainmatters-1090	7	16	this	this	DET
brainmatters-1090	7	17	pathway	pathway	NOUN
brainmatters-1090	7	18	.	.	PUNCT
brainmatters-1090	8	1	the	the	DET
brainmatters-1090	8	2	three	three	NUM
brainmatters-1090	8	3	types	type	NOUN
brainmatters-1090	8	4	of	of	ADP
brainmatters-1090	8	5	hedgehog	hedgehog	NOUN
brainmatters-1090	8	6	31	31	NUM
brainmatters-1090	8	7	in	in	ADP
brainmatters-1090	8	8	the	the	DET
brainmatters-1090	8	9	mammalian	mammalian	ADJ
brainmatters-1090	8	10	body	body	NOUN
brainmatters-1090	8	11	are	be	AUX
brainmatters-1090	8	12	sonic	sonic	ADJ
brainmatters-1090	8	13	hedgehog	hedgehog	NOUN
brainmatters-1090	8	14	(	(	PUNCT
brainmatters-1090	8	15	shh	shh	NOUN
brainmatters-1090	8	16	)	)	PUNCT
brainmatters-1090	8	17	,	,	PUNCT
brainmatters-1090	8	18	important	important	ADJ
brainmatters-1090	8	19	in	in	ADP
brainmatters-1090	8	20	the	the	DET
brainmatters-1090	8	21	specification	specification	NOUN
brainmatters-1090	8	22	of	of	ADP
brainmatters-1090	8	23	cells	cell	NOUN
brainmatters-1090	8	24	in	in	ADP
brainmatters-1090	8	25	the	the	DET
brainmatters-1090	8	26	nervous	nervous	ADJ
brainmatters-1090	8	27	system	system	NOUN
brainmatters-1090	8	28	,	,	PUNCT
brainmatters-1090	8	29	desert	desert	NOUN
brainmatters-1090	8	30	hedgehog	hedgehog	PROPN
brainmatters-1090	8	31	(	(	PUNCT
brainmatters-1090	8	32	dhh	dhh	PROPN
brainmatters-1090	8	33	)	)	PUNCT
brainmatters-1090	8	34	which	which	PRON
brainmatters-1090	8	35	is	be	AUX
brainmatters-1090	8	36	seen	see	VERB
brainmatters-1090	8	37	in	in	ADP
brainmatters-1090	8	38	the	the	DET
brainmatters-1090	8	39	hormoneproducing	hormoneproducing	NOUN
brainmatters-1090	8	40	gonad	gonad	ADJ
brainmatters-1090	8	41	glands	gland	NOUN
brainmatters-1090	8	42	involved	involve	VERB
brainmatters-1090	8	43	in	in	ADP
brainmatters-1090	8	44	reproduction	reproduction	NOUN
brainmatters-1090	8	45	,	,	PUNCT
brainmatters-1090	8	46	and	and	CCONJ
brainmatters-1090	8	47	indian	indian	ADJ
brainmatters-1090	8	48	hedgehog	hedgehog	PROPN
brainmatters-1090	8	49	(	(	PUNCT
brainmatters-1090	8	50	ihh	ihh	PROPN
brainmatters-1090	8	51	)	)	PUNCT
brainmatters-1090	8	52	which	which	PRON
brainmatters-1090	8	53	plays	play	VERB
brainmatters-1090	8	54	a	a	DET
brainmatters-1090	8	55	role	role	NOUN
brainmatters-1090	8	56	in	in	ADP
brainmatters-1090	8	57	skeletal	skeletal	ADJ
brainmatters-1090	8	58	development	development	NOUN
brainmatters-1090	8	59	(	(	PUNCT
brainmatters-1090	8	60	carballo	carballo	NOUN
brainmatters-1090	8	61	et	et	NOUN
brainmatters-1090	8	62	al	al	PROPN
brainmatters-1090	8	63	.	.	PROPN
brainmatters-1090	8	64	,	,	PUNCT
brainmatters-1090	8	65	2018	2018	NUM
brainmatters-1090	8	66	)	)	PUNCT
brainmatters-1090	8	67	.	.	PUNCT
brainmatters-1090	9	1	all	all	PRON
brainmatters-1090	9	2	of	of	ADP
brainmatters-1090	9	3	the	the	DET
brainmatters-1090	9	4	components	component	NOUN
brainmatters-1090	9	5	in	in	ADP
brainmatters-1090	9	6	the	the	DET
brainmatters-1090	9	7	hh	hh	PROPN
brainmatters-1090	9	8	pathway	pathway	NOUN
brainmatters-1090	9	9	are	be	AUX
brainmatters-1090	9	10	found	find	VERB
brainmatters-1090	9	11	in	in	ADP
brainmatters-1090	9	12	the	the	DET
brainmatters-1090	9	13	primary	primary	ADJ
brainmatters-1090	9	14	cilium	cilium	NOUN
brainmatters-1090	9	15	,	,	PUNCT
brainmatters-1090	9	16	which	which	PRON
brainmatters-1090	9	17	is	be	AUX
brainmatters-1090	9	18	an	an	DET
brainmatters-1090	9	19	immobile	immobile	ADJ
brainmatters-1090	9	20	organelle	organelle	NOUN
brainmatters-1090	9	21	that	that	PRON
brainmatters-1090	9	22	juts	jut	VERB
brainmatters-1090	9	23	out	out	ADP
brainmatters-1090	9	24	from	from	ADP
brainmatters-1090	9	25	the	the	DET
brainmatters-1090	9	26	side	side	NOUN
brainmatters-1090	9	27	of	of	ADP
brainmatters-1090	9	28	a	a	DET
brainmatters-1090	9	29	cell	cell	NOUN
brainmatters-1090	9	30	and	and	CCONJ
brainmatters-1090	9	31	can	can	AUX
brainmatters-1090	9	32	sense	sense	VERB
brainmatters-1090	9	33	the	the	DET
brainmatters-1090	9	34	surrounding	surround	VERB
brainmatters-1090	9	35	environment	environment	NOUN
brainmatters-1090	9	36	(	(	PUNCT
brainmatters-1090	9	37	gigante	gigante	PROPN
brainmatters-1090	9	38	&	&	CCONJ
brainmatters-1090	9	39	caspary	caspary	PROPN
brainmatters-1090	9	40	,	,	PUNCT
brainmatters-1090	9	41	2020	2020	NUM
brainmatters-1090	9	42	)	)	PUNCT
brainmatters-1090	9	43	.	.	PUNCT
brainmatters-1090	10	1	when	when	SCONJ
brainmatters-1090	10	2	the	the	DET
brainmatters-1090	10	3	pathway	pathway	NOUN
brainmatters-1090	10	4	is	be	AUX
brainmatters-1090	10	5	regulated	regulate	VERB
brainmatters-1090	10	6	,	,	PUNCT
brainmatters-1090	10	7	typical	typical	ADJ
brainmatters-1090	10	8	development	development	NOUN
brainmatters-1090	10	9	can	can	AUX
brainmatters-1090	10	10	occur	occur	VERB
brainmatters-1090	10	11	.	.	PUNCT
brainmatters-1090	11	1	however	however	ADV
brainmatters-1090	11	2	,	,	PUNCT
brainmatters-1090	11	3	the	the	DET
brainmatters-1090	11	4	dysregulation	dysregulation	NOUN
brainmatters-1090	11	5	of	of	ADP
brainmatters-1090	11	6	the	the	DET
brainmatters-1090	11	7	hh	hh	PROPN
brainmatters-1090	11	8	signaling	signal	VERB
brainmatters-1090	11	9	pathway	pathway	NOUN
brainmatters-1090	11	10	may	may	AUX
brainmatters-1090	11	11	lead	lead	VERB
brainmatters-1090	11	12	to	to	ADP
brainmatters-1090	11	13	a	a	DET
brainmatters-1090	11	14	variety	variety	NOUN
brainmatters-1090	11	15	of	of	ADP
brainmatters-1090	11	16	diseases	disease	NOUN
brainmatters-1090	11	17	and	and	CCONJ
brainmatters-1090	11	18	disorders	disorder	NOUN
brainmatters-1090	11	19	,	,	PUNCT
brainmatters-1090	11	20	including	include	VERB
brainmatters-1090	11	21	tumorigenesis	tumorigenesis	NOUN
brainmatters-1090	11	22	of	of	ADP
brainmatters-1090	11	23	medulloblastoma	medulloblastoma	NOUN
brainmatters-1090	11	24	,	,	PUNCT
brainmatters-1090	11	25	the	the	DET
brainmatters-1090	11	26	most	most	ADV
brainmatters-1090	11	27	common	common	ADJ
brainmatters-1090	11	28	malignant	malignant	ADJ
brainmatters-1090	11	29	brain	brain	NOUN
brainmatters-1090	11	30	tumor	tumor	NOUN
brainmatters-1090	11	31	.	.	PUNCT
brainmatters-1090	12	1	the	the	DET
brainmatters-1090	12	2	signal	signal	ADJ
brainmatters-1090	12	3	transduction	transduction	NOUN
brainmatters-1090	12	4	pathway	pathway	NOUN
brainmatters-1090	12	5	of	of	ADP
brainmatters-1090	12	6	sonic	sonic	ADJ
brainmatters-1090	12	7	hedgehog	hedgehog	NOUN
brainmatters-1090	12	8	the	the	DET
brainmatters-1090	12	9	shh	shh	PROPN
brainmatters-1090	12	10	pathway	pathway	NOUN
brainmatters-1090	12	11	is	be	AUX
brainmatters-1090	12	12	most	most	ADV
brainmatters-1090	12	13	commonly	commonly	ADV
brainmatters-1090	12	14	activated	activate	VERB
brainmatters-1090	12	15	by	by	ADP
brainmatters-1090	12	16	canonical	canonical	ADJ
brainmatters-1090	12	17	signaling	signaling	NOUN
brainmatters-1090	12	18	,	,	PUNCT
brainmatters-1090	12	19	in	in	ADP
brainmatters-1090	12	20	which	which	PRON
brainmatters-1090	12	21	there	there	PRON
brainmatters-1090	12	22	are	be	VERB
brainmatters-1090	12	23	ligand	ligand	NOUN
brainmatters-1090	12	24	-	-	PUNCT
brainmatters-1090	12	25	dependent	dependent	ADJ
brainmatters-1090	12	26	interactions	interaction	NOUN
brainmatters-1090	12	27	or	or	CCONJ
brainmatters-1090	12	28	receptor	receptor	NOUN
brainmatters-1090	12	29	-	-	PUNCT
brainmatters-1090	12	30	induced	induce	VERB
brainmatters-1090	12	31	signalings	signaling	NOUN
brainmatters-1090	12	32	.	.	PUNCT
brainmatters-1090	13	1	without	without	ADP
brainmatters-1090	13	2	the	the	DET
brainmatters-1090	13	3	glycoprotein	glycoprotein	PROPN
brainmatters-1090	13	4	shh	shh	NOUN
brainmatters-1090	13	5	,	,	PUNCT
brainmatters-1090	13	6	this	this	DET
brainmatters-1090	13	7	signaling	signal	VERB
brainmatters-1090	13	8	pathway	pathway	NOUN
brainmatters-1090	13	9	does	do	AUX
brainmatters-1090	13	10	not	not	PART
brainmatters-1090	13	11	occur	occur	VERB
brainmatters-1090	13	12	.	.	PUNCT
brainmatters-1090	14	1	smoothened	smoothen	VERB
brainmatters-1090	14	2	(	(	PUNCT
brainmatters-1090	14	3	smo	smo	PROPN
brainmatters-1090	14	4	)	)	PUNCT
brainmatters-1090	14	5	is	be	AUX
brainmatters-1090	14	6	a	a	DET
brainmatters-1090	14	7	gpcr	gpcr	ADJ
brainmatters-1090	14	8	-	-	PUNCT
brainmatters-1090	14	9	like	like	ADJ
brainmatters-1090	14	10	transmembrane	transmembrane	ADJ
brainmatters-1090	14	11	protein	protein	NOUN
brainmatters-1090	14	12	that	that	PRON
brainmatters-1090	14	13	is	be	AUX
brainmatters-1090	14	14	usually	usually	ADV
brainmatters-1090	14	15	inhibited	inhibit	VERB
brainmatters-1090	14	16	by	by	ADP
brainmatters-1090	14	17	another	another	DET
brainmatters-1090	14	18	transmembrane	transmembrane	ADJ
brainmatters-1090	14	19	protein	protein	NOUN
brainmatters-1090	14	20	called	call	VERB
brainmatters-1090	14	21	patched	patch	VERB
brainmatters-1090	14	22	(	(	PUNCT
brainmatters-1090	14	23	ptch	ptch	NOUN
brainmatters-1090	14	24	1	1	NUM
brainmatters-1090	14	25	)	)	PUNCT
brainmatters-1090	14	26	when	when	SCONJ
brainmatters-1090	14	27	the	the	DET
brainmatters-1090	14	28	glycoprotein	glycoprotein	NOUN
brainmatters-1090	14	29	shh	shh	NOUN
brainmatters-1090	14	30	is	be	AUX
brainmatters-1090	14	31	absent	absent	ADJ
brainmatters-1090	14	32	.	.	PUNCT
brainmatters-1090	15	1	gli	gli	NOUN
brainmatters-1090	15	2	transcription	transcription	NOUN
brainmatters-1090	15	3	factors	factor	NOUN
brainmatters-1090	15	4	are	be	AUX
brainmatters-1090	15	5	present	present	ADJ
brainmatters-1090	15	6	in	in	ADP
brainmatters-1090	15	7	the	the	DET
brainmatters-1090	15	8	cilia	cilia	NOUN
brainmatters-1090	15	9	in	in	ADP
brainmatters-1090	15	10	a	a	DET
brainmatters-1090	15	11	complex	complex	NOUN
brainmatters-1090	15	12	with	with	ADP
brainmatters-1090	15	13	kif7	kif7	PROPN
brainmatters-1090	15	14	,	,	PUNCT
brainmatters-1090	15	15	an	an	DET
brainmatters-1090	15	16	ift	ift	NOUN
brainmatters-1090	15	17	-	-	PUNCT
brainmatters-1090	15	18	kinesin	kinesin	NOUN
brainmatters-1090	15	19	that	that	PRON
brainmatters-1090	15	20	moves	move	VERB
brainmatters-1090	15	21	necessary	necessary	ADJ
brainmatters-1090	15	22	materials	material	NOUN
brainmatters-1090	15	23	toward	toward	ADP
brainmatters-1090	15	24	the	the	DET
brainmatters-1090	15	25	cilium	cilium	NOUN
brainmatters-1090	15	26	during	during	ADP
brainmatters-1090	15	27	cellular	cellular	ADJ
brainmatters-1090	15	28	signaling	signaling	NOUN
brainmatters-1090	15	29	.	.	PUNCT
brainmatters-1090	16	1	additionally	additionally	ADV
brainmatters-1090	16	2	,	,	PUNCT
brainmatters-1090	16	3	the	the	DET
brainmatters-1090	16	4	repressor	repressor	NOUN
brainmatters-1090	16	5	factor	factor	NOUN
brainmatters-1090	16	6	sufu	sufu	NOUN
brainmatters-1090	16	7	promotes	promote	VERB
brainmatters-1090	16	8	the	the	DET
brainmatters-1090	16	9	truncation	truncation	NOUN
brainmatters-1090	16	10	of	of	ADP
brainmatters-1090	16	11	gli	gli	NOUN
brainmatters-1090	16	12	proteins	protein	NOUN
brainmatters-1090	16	13	,	,	PUNCT
brainmatters-1090	16	14	in	in	ADP
brainmatters-1090	16	15	which	which	PRON
brainmatters-1090	16	16	gli	gli	NOUN
brainmatters-1090	16	17	proteins	protein	NOUN
brainmatters-1090	16	18	are	be	AUX
brainmatters-1090	16	19	shortened	shorten	VERB
brainmatters-1090	16	20	and	and	CCONJ
brainmatters-1090	16	21	turned	turn	VERB
brainmatters-1090	16	22	into	into	ADP
brainmatters-1090	16	23	the	the	DET
brainmatters-1090	16	24	glir	glir	NOUN
brainmatters-1090	16	25	repressor	repressor	NOUN
brainmatters-1090	16	26	form	form	NOUN
brainmatters-1090	16	27	.	.	PUNCT
brainmatters-1090	17	1	this	this	PRON
brainmatters-1090	17	2	inhibits	inhibit	VERB
brainmatters-1090	17	3	the	the	DET
brainmatters-1090	17	4	transcription	transcription	NOUN
brainmatters-1090	17	5	of	of	ADP
brainmatters-1090	17	6	shh	shh	NOUN
brainmatters-1090	17	7	target	target	NOUN
brainmatters-1090	17	8	genes	gene	NOUN
brainmatters-1090	17	9	(	(	PUNCT
brainmatters-1090	17	10	traiffort	traiffort	VERB
brainmatters-1090	17	11	et	et	PROPN
brainmatters-1090	17	12	al	al	PROPN
brainmatters-1090	17	13	.	.	PROPN
brainmatters-1090	17	14	,	,	PUNCT
brainmatters-1090	17	15	2012	2012	NUM
brainmatters-1090	17	16	)	)	PUNCT
brainmatters-1090	17	17	.	.	PUNCT
brainmatters-1090	18	1	during	during	ADP
brainmatters-1090	18	2	shh	shh	PROPN
brainmatters-1090	18	3	canonical	canonical	ADJ
brainmatters-1090	18	4	signaling	signaling	NOUN
brainmatters-1090	18	5	,	,	PUNCT
brainmatters-1090	18	6	the	the	DET
brainmatters-1090	18	7	glycoprotein	glycoprotein	NOUN
brainmatters-1090	18	8	shh	shh	INTJ
brainmatters-1090	18	9	binds	bind	VERB
brainmatters-1090	18	10	to	to	PART
brainmatters-1090	18	11	and	and	CCONJ
brainmatters-1090	18	12	inactivates	inactivate	VERB
brainmatters-1090	18	13	ptch	ptch	VERB
brainmatters-1090	18	14	1	1	NUM
brainmatters-1090	18	15	,	,	PUNCT
brainmatters-1090	18	16	which	which	PRON
brainmatters-1090	18	17	,	,	PUNCT
brainmatters-1090	18	18	in	in	ADP
brainmatters-1090	18	19	turn	turn	NOUN
brainmatters-1090	18	20	,	,	PUNCT
brainmatters-1090	18	21	activates	activate	VERB
brainmatters-1090	18	22	smo	smo	PROPN
brainmatters-1090	18	23	.	.	PUNCT
brainmatters-1090	19	1	when	when	SCONJ
brainmatters-1090	19	2	this	this	DET
brainmatters-1090	19	3	protein	protein	NOUN
brainmatters-1090	19	4	is	be	AUX
brainmatters-1090	19	5	activated	activate	VERB
brainmatters-1090	19	6	,	,	PUNCT
brainmatters-1090	19	7	it	it	PRON
brainmatters-1090	19	8	accumulates	accumulate	VERB
brainmatters-1090	19	9	at	at	ADP
brainmatters-1090	19	10	the	the	DET
brainmatters-1090	19	11	primary	primary	ADJ
brainmatters-1090	19	12	cilium	cilium	NOUN
brainmatters-1090	19	13	.	.	PUNCT
brainmatters-1090	20	1	this	this	DET
brainmatters-1090	20	2	accumulation	accumulation	NOUN
brainmatters-1090	20	3	relieves	relieve	VERB
brainmatters-1090	20	4	the	the	DET
brainmatters-1090	20	5	inhibition	inhibition	NOUN
brainmatters-1090	20	6	that	that	SCONJ
brainmatters-1090	20	7	sufu	sufu	NOUN
brainmatters-1090	20	8	exerts	exert	VERB
brainmatters-1090	20	9	on	on	ADP
brainmatters-1090	20	10	gli	gli	NOUN
brainmatters-1090	20	11	proteins	protein	NOUN
brainmatters-1090	20	12	,	,	PUNCT
brainmatters-1090	20	13	which	which	PRON
brainmatters-1090	20	14	allows	allow	VERB
brainmatters-1090	20	15	them	they	PRON
brainmatters-1090	20	16	to	to	PART
brainmatters-1090	20	17	turn	turn	VERB
brainmatters-1090	20	18	into	into	ADP
brainmatters-1090	20	19	the	the	DET
brainmatters-1090	20	20	glia	glia	NOUN
brainmatters-1090	20	21	activated	activate	VERB
brainmatters-1090	20	22	form	form	NOUN
brainmatters-1090	20	23	,	,	PUNCT
brainmatters-1090	20	24	and	and	CCONJ
brainmatters-1090	20	25	move	move	VERB
brainmatters-1090	20	26	into	into	ADP
brainmatters-1090	20	27	the	the	DET
brainmatters-1090	20	28	nucleus	nucleus	NOUN
brainmatters-1090	20	29	to	to	PART
brainmatters-1090	20	30	activate	activate	VERB
brainmatters-1090	20	31	the	the	DET
brainmatters-1090	20	32	transcription	transcription	NOUN
brainmatters-1090	20	33	of	of	ADP
brainmatters-1090	20	34	shh	shh	NOUN
brainmatters-1090	20	35	target	target	NOUN
brainmatters-1090	20	36	genes	gene	NOUN
brainmatters-1090	20	37	.	.	PUNCT
brainmatters-1090	21	1	each	each	DET
brainmatters-1090	21	2	target	target	NOUN
brainmatters-1090	21	3	gene	gene	NOUN
brainmatters-1090	21	4	has	have	VERB
brainmatters-1090	21	5	a	a	DET
brainmatters-1090	21	6	specific	specific	ADJ
brainmatters-1090	21	7	function	function	NOUN
brainmatters-1090	21	8	.	.	PUNCT
brainmatters-1090	22	1	for	for	ADP
brainmatters-1090	22	2	example	example	NOUN
brainmatters-1090	22	3	,	,	PUNCT
brainmatters-1090	22	4	gli1	gli1	PROPN
brainmatters-1090	22	5	and	and	CCONJ
brainmatters-1090	22	6	ptch1	ptch1	PROPN
brainmatters-1090	22	7	are	be	AUX
brainmatters-1090	22	8	involved	involve	VERB
brainmatters-1090	22	9	in	in	ADP
brainmatters-1090	22	10	pathway	pathway	NOUN
brainmatters-1090	22	11	feedback	feedback	NOUN
brainmatters-1090	22	12	,	,	PUNCT
brainmatters-1090	22	13	cyclin	cyclin	NOUN
brainmatters-1090	22	14	-	-	PUNCT
brainmatters-1090	22	15	d1	d1	PROPN
brainmatters-1090	22	16	and	and	CCONJ
brainmatters-1090	22	17	myc	myc	NOUN
brainmatters-1090	22	18	promote	promote	VERB
brainmatters-1090	22	19	cell	cell	NOUN
brainmatters-1090	22	20	proliferation	proliferation	NOUN
brainmatters-1090	22	21	,	,	PUNCT
brainmatters-1090	22	22	and	and	CCONJ
brainmatters-1090	22	23	ccnd2	ccnd2	NOUN
brainmatters-1090	22	24	and	and	CCONJ
brainmatters-1090	22	25	ccne1	ccne1	PROPN
brainmatters-1090	22	26	regulate	regulate	VERB
brainmatters-1090	22	27	the	the	DET
brainmatters-1090	22	28	cell	cell	NOUN
brainmatters-1090	22	29	cycle	cycle	NOUN
brainmatters-1090	22	30	.	.	PUNCT
brainmatters-1090	23	1	in	in	ADP
brainmatters-1090	23	2	addition	addition	NOUN
brainmatters-1090	23	3	,	,	PUNCT
brainmatters-1090	23	4	bcl2	bcl2	PROPN
brainmatters-1090	23	5	regulates	regulate	VERB
brainmatters-1090	23	6	apoptosis	apoptosis	NOUN
brainmatters-1090	23	7	,	,	PUNCT
brainmatters-1090	23	8	agn1/2	agn1/2	NUM
brainmatters-1090	23	9	are	be	AUX
brainmatters-1090	23	10	involved	involve	VERB
brainmatters-1090	23	11	in	in	ADP
brainmatters-1090	23	12	angiogenesis	angiogenesis	NOUN
brainmatters-1090	23	13	,	,	PUNCT
brainmatters-1090	23	14	snail	snail	NOUN
brainmatters-1090	23	15	is	be	AUX
brainmatters-1090	23	16	involved	involve	VERB
brainmatters-1090	23	17	with	with	ADP
brainmatters-1090	23	18	epithelial	epithelial	ADJ
brainmatters-1090	23	19	-	-	PUNCT
brainmatters-1090	23	20	tomesenchymal	tomesenchymal	ADJ
brainmatters-1090	23	21	transitions	transition	NOUN
brainmatters-1090	23	22	,	,	PUNCT
brainmatters-1090	23	23	and	and	CCONJ
brainmatters-1090	23	24	nanog	nanog	PROPN
brainmatters-1090	23	25	and	and	CCONJ
brainmatters-1090	23	26	sox2	sox2	NOUN
brainmatters-1090	23	27	regulate	regulate	VERB
brainmatters-1090	23	28	the	the	DET
brainmatters-1090	23	29	self	self	NOUN
brainmatters-1090	23	30	-	-	PUNCT
brainmatters-1090	23	31	renewal	renewal	NOUN
brainmatters-1090	23	32	of	of	ADP
brainmatters-1090	23	33	stem	stem	NOUN
brainmatters-1090	23	34	cells	cell	NOUN
brainmatters-1090	23	35	.	.	PUNCT
brainmatters-1090	24	1	brain	brain	NOUN
brainmatters-1090	24	2	matters	matter	NOUN
brainmatters-1090	24	3	vol	vol	NOUN
brainmatters-1090	24	4	.	.	PROPN
brainmatters-1090	24	5	8	8	NUM
brainmatters-1090	24	6	2025	2025	NUM
brainmatters-1090	24	7	32	32	NUM
brainmatters-1090	24	8	dysregulation	dysregulation	NOUN
brainmatters-1090	24	9	of	of	ADP
brainmatters-1090	24	10	hh	hh	PROPN
brainmatters-1090	24	11	signaling	signal	VERB
brainmatters-1090	24	12	pathway	pathway	NOUN
brainmatters-1090	24	13	when	when	SCONJ
brainmatters-1090	24	14	the	the	DET
brainmatters-1090	24	15	hh	hh	NOUN
brainmatters-1090	24	16	signaling	signal	VERB
brainmatters-1090	24	17	pathway	pathway	NOUN
brainmatters-1090	24	18	is	be	AUX
brainmatters-1090	24	19	not	not	PART
brainmatters-1090	24	20	carefully	carefully	ADV
brainmatters-1090	24	21	controlled	control	VERB
brainmatters-1090	24	22	,	,	PUNCT
brainmatters-1090	24	23	the	the	DET
brainmatters-1090	24	24	effects	effect	NOUN
brainmatters-1090	24	25	on	on	ADP
brainmatters-1090	24	26	the	the	DET
brainmatters-1090	24	27	development	development	NOUN
brainmatters-1090	24	28	of	of	ADP
brainmatters-1090	24	29	cells	cell	NOUN
brainmatters-1090	24	30	and	and	CCONJ
brainmatters-1090	24	31	tissues	tissue	NOUN
brainmatters-1090	24	32	can	can	AUX
brainmatters-1090	24	33	be	be	AUX
brainmatters-1090	24	34	very	very	ADV
brainmatters-1090	24	35	harmful	harmful	ADJ
brainmatters-1090	24	36	.	.	PUNCT
brainmatters-1090	25	1	the	the	DET
brainmatters-1090	25	2	aberrant	aberrant	ADJ
brainmatters-1090	25	3	activation	activation	NOUN
brainmatters-1090	25	4	of	of	ADP
brainmatters-1090	25	5	the	the	DET
brainmatters-1090	25	6	hh	hh	PROPN
brainmatters-1090	25	7	signaling	signal	VERB
brainmatters-1090	25	8	pathway	pathway	NOUN
brainmatters-1090	25	9	is	be	AUX
brainmatters-1090	25	10	caused	cause	VERB
brainmatters-1090	25	11	either	either	CCONJ
brainmatters-1090	25	12	by	by	ADP
brainmatters-1090	25	13	mutations	mutation	NOUN
brainmatters-1090	25	14	in	in	ADP
brainmatters-1090	25	15	pathway	pathway	NOUN
brainmatters-1090	25	16	-	-	PUNCT
brainmatters-1090	25	17	related	relate	VERB
brainmatters-1090	25	18	genes	gene	NOUN
brainmatters-1090	25	19	or	or	CCONJ
brainmatters-1090	25	20	by	by	ADP
brainmatters-1090	25	21	the	the	DET
brainmatters-1090	25	22	excessive	excessive	ADJ
brainmatters-1090	25	23	expression	expression	NOUN
brainmatters-1090	25	24	of	of	ADP
brainmatters-1090	25	25	hh	hh	NOUN
brainmatters-1090	25	26	signaling	signal	VERB
brainmatters-1090	25	27	molecules	molecule	NOUN
brainmatters-1090	25	28	.	.	PUNCT
brainmatters-1090	26	1	this	this	DET
brainmatters-1090	26	2	uncontrolled	uncontrolled	ADJ
brainmatters-1090	26	3	activation	activation	NOUN
brainmatters-1090	26	4	is	be	AUX
brainmatters-1090	26	5	what	what	PRON
brainmatters-1090	26	6	leads	lead	VERB
brainmatters-1090	26	7	to	to	ADP
brainmatters-1090	26	8	tumorigenesis	tumorigenesis	NOUN
brainmatters-1090	26	9	.	.	PUNCT
brainmatters-1090	27	1	the	the	DET
brainmatters-1090	27	2	shh	shh	PROPN
brainmatters-1090	27	3	pathway	pathway	NOUN
brainmatters-1090	27	4	plays	play	VERB
brainmatters-1090	27	5	a	a	DET
brainmatters-1090	27	6	particularly	particularly	ADV
brainmatters-1090	27	7	important	important	ADJ
brainmatters-1090	27	8	role	role	NOUN
brainmatters-1090	27	9	in	in	ADP
brainmatters-1090	27	10	regulating	regulate	VERB
brainmatters-1090	27	11	neural	neural	ADJ
brainmatters-1090	27	12	development	development	NOUN
brainmatters-1090	27	13	in	in	ADP
brainmatters-1090	27	14	the	the	DET
brainmatters-1090	27	15	cerebellum	cerebellum	NOUN
brainmatters-1090	27	16	,	,	PUNCT
brainmatters-1090	27	17	a	a	DET
brainmatters-1090	27	18	part	part	NOUN
brainmatters-1090	27	19	of	of	ADP
brainmatters-1090	27	20	the	the	DET
brainmatters-1090	27	21	brain	brain	NOUN
brainmatters-1090	27	22	linked	link	VERB
brainmatters-1090	27	23	to	to	ADP
brainmatters-1090	27	24	motor	motor	NOUN
brainmatters-1090	27	25	learning	learning	NOUN
brainmatters-1090	27	26	and	and	CCONJ
brainmatters-1090	27	27	coordination	coordination	NOUN
brainmatters-1090	27	28	.	.	PUNCT
brainmatters-1090	28	1	aberrant	aberrant	ADJ
brainmatters-1090	28	2	activation	activation	NOUN
brainmatters-1090	28	3	of	of	ADP
brainmatters-1090	28	4	this	this	DET
brainmatters-1090	28	5	pathway	pathway	NOUN
brainmatters-1090	28	6	is	be	AUX
brainmatters-1090	28	7	linked	link	VERB
brainmatters-1090	28	8	to	to	ADP
brainmatters-1090	28	9	pathway	pathway	NOUN
brainmatters-1090	28	10	-	-	PUNCT
brainmatters-1090	28	11	activating	activate	VERB
brainmatters-1090	28	12	mutations	mutation	NOUN
brainmatters-1090	28	13	in	in	ADP
brainmatters-1090	28	14	ptc	ptc	PROPN
brainmatters-1090	28	15	(	(	PUNCT
brainmatters-1090	28	16	a	a	DET
brainmatters-1090	28	17	protein	protein	NOUN
brainmatters-1090	28	18	found	find	VERB
brainmatters-1090	28	19	in	in	ADP
brainmatters-1090	28	20	drosophila	drosophila	NOUN
brainmatters-1090	28	21	,	,	PUNCT
brainmatters-1090	28	22	the	the	DET
brainmatters-1090	28	23	common	common	ADJ
brainmatters-1090	28	24	fruit	fruit	NOUN
brainmatters-1090	28	25	fly	fly	NOUN
brainmatters-1090	28	26	,	,	PUNCT
brainmatters-1090	28	27	that	that	PRON
brainmatters-1090	28	28	is	be	AUX
brainmatters-1090	28	29	similar	similar	ADJ
brainmatters-1090	28	30	to	to	PART
brainmatters-1090	28	31	ptch	ptch	VERB
brainmatters-1090	28	32	in	in	ADP
brainmatters-1090	28	33	humans	human	NOUN
brainmatters-1090	28	34	)	)	PUNCT
brainmatters-1090	28	35	,	,	PUNCT
brainmatters-1090	28	36	sufu	sufu	X
brainmatters-1090	28	37	,	,	PUNCT
brainmatters-1090	28	38	or	or	CCONJ
brainmatters-1090	28	39	smo	smo	PROPN
brainmatters-1090	28	40	,	,	PUNCT
brainmatters-1090	28	41	which	which	PRON
brainmatters-1090	28	42	all	all	PRON
brainmatters-1090	28	43	have	have	VERB
brainmatters-1090	28	44	key	key	ADJ
brainmatters-1090	28	45	roles	role	NOUN
brainmatters-1090	28	46	in	in	ADP
brainmatters-1090	28	47	the	the	DET
brainmatters-1090	28	48	figure	figure	NOUN
brainmatters-1090	28	49	1	1	NUM
brainmatters-1090	28	50	.	.	PUNCT
brainmatters-1090	28	51	canonical	canonical	ADJ
brainmatters-1090	28	52	activation	activation	NOUN
brainmatters-1090	28	53	of	of	ADP
brainmatters-1090	28	54	the	the	DET
brainmatters-1090	28	55	sonic	sonic	ADJ
brainmatters-1090	28	56	hedgehog	hedgehog	PROPN
brainmatters-1090	28	57	(	(	PUNCT
brainmatters-1090	28	58	shh	shh	NOUN
brainmatters-1090	28	59	)	)	PUNCT
brainmatters-1090	28	60	signaling	signal	VERB
brainmatters-1090	28	61	pathway	pathway	NOUN
brainmatters-1090	28	62	occurring	occur	VERB
brainmatters-1090	28	63	at	at	ADP
brainmatters-1090	28	64	the	the	DET
brainmatters-1090	28	65	primary	primary	ADJ
brainmatters-1090	28	66	cilium	cilium	NOUN
brainmatters-1090	28	67	(	(	PUNCT
brainmatters-1090	28	68	adapted	adapt	VERB
brainmatters-1090	28	69	from	from	ADP
brainmatters-1090	28	70	robbins	robbin	NOUN
brainmatters-1090	28	71	et	et	PROPN
brainmatters-1090	28	72	al	al	PROPN
brainmatters-1090	28	73	.	.	PROPN
brainmatters-1090	28	74	,	,	PUNCT
brainmatters-1090	28	75	2012	2012	NUM
brainmatters-1090	28	76	)	)	PUNCT
brainmatters-1090	28	77	.	.	PUNCT
brainmatters-1090	29	1	regulation	regulation	NOUN
brainmatters-1090	29	2	of	of	ADP
brainmatters-1090	29	3	the	the	DET
brainmatters-1090	29	4	hh	hh	PROPN
brainmatters-1090	29	5	signaling	signal	VERB
brainmatters-1090	29	6	pathway	pathway	NOUN
brainmatters-1090	29	7	.	.	PUNCT
brainmatters-1090	30	1	it	it	PRON
brainmatters-1090	30	2	has	have	AUX
brainmatters-1090	30	3	been	be	AUX
brainmatters-1090	30	4	seen	see	VERB
brainmatters-1090	30	5	in	in	ADP
brainmatters-1090	30	6	mice	mice	NOUN
brainmatters-1090	30	7	medulloblastoma	medulloblastoma	PROPN
brainmatters-1090	30	8	brain	brain	NOUN
brainmatters-1090	30	9	tumor	tumor	NOUN
brainmatters-1090	30	10	stem	stem	NOUN
brainmatters-1090	30	11	cells	cell	NOUN
brainmatters-1090	30	12	that	that	SCONJ
brainmatters-1090	30	13	there	there	PRON
brainmatters-1090	30	14	is	be	VERB
brainmatters-1090	30	15	markedly	markedly	ADV
brainmatters-1090	30	16	higher	high	ADJ
brainmatters-1090	30	17	gli1	gli1	NOUN
brainmatters-1090	30	18	expression	expression	NOUN
brainmatters-1090	30	19	than	than	ADP
brainmatters-1090	30	20	in	in	ADP
brainmatters-1090	30	21	the	the	DET
brainmatters-1090	30	22	normal	normal	ADJ
brainmatters-1090	30	23	stem	stem	NOUN
brainmatters-1090	30	24	cells	cell	NOUN
brainmatters-1090	30	25	.	.	PUNCT
brainmatters-1090	31	1	these	these	DET
brainmatters-1090	31	2	cells	cell	NOUN
brainmatters-1090	31	3	do	do	AUX
brainmatters-1090	31	4	not	not	PART
brainmatters-1090	31	5	undergo	undergo	VERB
brainmatters-1090	31	6	apoptosis	apoptosis	NOUN
brainmatters-1090	31	7	(	(	PUNCT
brainmatters-1090	31	8	programmed	program	VERB
brainmatters-1090	31	9	cell	cell	NOUN
brainmatters-1090	31	10	death	death	NOUN
brainmatters-1090	31	11	)	)	PUNCT
brainmatters-1090	31	12	.	.	PUNCT
brainmatters-1090	32	1	instead	instead	ADV
brainmatters-1090	32	2	,	,	PUNCT
brainmatters-1090	32	3	they	they	PRON
brainmatters-1090	32	4	continue	continue	VERB
brainmatters-1090	32	5	to	to	PART
brainmatters-1090	32	6	proliferate	proliferate	VERB
brainmatters-1090	32	7	when	when	SCONJ
brainmatters-1090	32	8	they	they	PRON
brainmatters-1090	32	9	are	be	AUX
brainmatters-1090	32	10	not	not	PART
brainmatters-1090	32	11	supposed	suppose	VERB
brainmatters-1090	32	12	to	to	PART
brainmatters-1090	32	13	.	.	PUNCT
brainmatters-1090	33	1	this	this	PRON
brainmatters-1090	33	2	suggests	suggest	VERB
brainmatters-1090	33	3	that	that	SCONJ
brainmatters-1090	33	4	there	there	PRON
brainmatters-1090	33	5	is	be	VERB
brainmatters-1090	33	6	a	a	DET
brainmatters-1090	33	7	lack	lack	NOUN
brainmatters-1090	33	8	of	of	ADP
brainmatters-1090	33	9	protective	protective	ADJ
brainmatters-1090	33	10	mechanisms	mechanism	NOUN
brainmatters-1090	33	11	in	in	ADP
brainmatters-1090	33	12	place	place	NOUN
brainmatters-1090	33	13	for	for	ADP
brainmatters-1090	33	14	these	these	DET
brainmatters-1090	33	15	malignant	malignant	ADJ
brainmatters-1090	33	16	stem	stem	NOUN
brainmatters-1090	33	17	cells	cell	NOUN
brainmatters-1090	33	18	,	,	PUNCT
brainmatters-1090	33	19	whereas	whereas	SCONJ
brainmatters-1090	33	20	non	non	ADJ
brainmatters-1090	33	21	-	-	ADJ
brainmatters-1090	33	22	malignant	malignant	ADJ
brainmatters-1090	33	23	stem	stem	NOUN
brainmatters-1090	33	24	cells	cell	NOUN
brainmatters-1090	33	25	are	be	AUX
brainmatters-1090	33	26	able	able	ADJ
brainmatters-1090	33	27	to	to	PART
brainmatters-1090	33	28	control	control	VERB
brainmatters-1090	33	29	excessive	excessive	ADJ
brainmatters-1090	33	30	proliferation	proliferation	NOUN
brainmatters-1090	33	31	in	in	ADP
brainmatters-1090	33	32	response	response	NOUN
brainmatters-1090	33	33	to	to	ADP
brainmatters-1090	33	34	signals	signal	NOUN
brainmatters-1090	33	35	that	that	PRON
brainmatters-1090	33	36	promote	promote	VERB
brainmatters-1090	33	37	mitosis	mitosis	NOUN
brainmatters-1090	33	38	.	.	PUNCT
brainmatters-1090	34	1	interestingly	interestingly	ADV
brainmatters-1090	34	2	,	,	PUNCT
brainmatters-1090	34	3	only	only	ADV
brainmatters-1090	34	4	25	25	NUM
brainmatters-1090	34	5	%	%	NOUN
brainmatters-1090	34	6	of	of	ADP
brainmatters-1090	34	7	medulloblastomas	medulloblastoma	NOUN
brainmatters-1090	34	8	displaying	display	VERB
brainmatters-1090	34	9	abnormally	abnormally	ADV
brainmatters-1090	34	10	high	high	ADJ
brainmatters-1090	34	11	hh	hh	ADJ
brainmatters-1090	34	12	signaling	signal	VERB
brainmatters-1090	34	13	pathway	pathway	NOUN
brainmatters-1090	34	14	activation	activation	NOUN
brainmatters-1090	34	15	have	have	AUX
brainmatters-1090	34	16	been	be	AUX
brainmatters-1090	34	17	found	find	VERB
brainmatters-1090	34	18	with	with	ADP
brainmatters-1090	34	19	mutations	mutation	NOUN
brainmatters-1090	34	20	in	in	ADP
brainmatters-1090	34	21	ptc	ptc	PROPN
brainmatters-1090	34	22	,	,	PUNCT
brainmatters-1090	34	23	sufu	sufu	X
brainmatters-1090	34	24	,	,	PUNCT
brainmatters-1090	34	25	or	or	CCONJ
brainmatters-1090	34	26	smo	smo	PROPN
brainmatters-1090	34	27	(	(	PUNCT
brainmatters-1090	34	28	traiffort	traiffort	VERB
brainmatters-1090	34	29	et	et	PROPN
brainmatters-1090	34	30	al	al	PROPN
brainmatters-1090	34	31	.	.	PROPN
brainmatters-1090	34	32	,	,	PUNCT
brainmatters-1090	34	33	2012	2012	NUM
brainmatters-1090	34	34	)	)	PUNCT
brainmatters-1090	34	35	.	.	PUNCT
brainmatters-1090	35	1	this	this	PRON
brainmatters-1090	35	2	means	mean	VERB
brainmatters-1090	35	3	that	that	SCONJ
brainmatters-1090	35	4	there	there	PRON
brainmatters-1090	35	5	are	be	VERB
brainmatters-1090	35	6	other	other	ADJ
brainmatters-1090	35	7	genetic	genetic	ADJ
brainmatters-1090	35	8	pathways	pathway	NOUN
brainmatters-1090	35	9	associated	associate	VERB
brainmatters-1090	35	10	with	with	ADP
brainmatters-1090	35	11	hh	hh	PROPN
brainmatters-1090	35	12	signaling	signal	VERB
brainmatters-1090	35	13	that	that	PRON
brainmatters-1090	35	14	play	play	VERB
brainmatters-1090	35	15	a	a	DET
brainmatters-1090	35	16	role	role	NOUN
brainmatters-1090	35	17	in	in	ADP
brainmatters-1090	35	18	the	the	DET
brainmatters-1090	35	19	development	development	NOUN
brainmatters-1090	35	20	of	of	ADP
brainmatters-1090	35	21	cancer	cancer	NOUN
brainmatters-1090	35	22	cells	cell	NOUN
brainmatters-1090	35	23	.	.	PUNCT
brainmatters-1090	36	1	tumor	tumor	NOUN
brainmatters-1090	36	2	suppressors	suppressor	NOUN
brainmatters-1090	36	3	are	be	AUX
brainmatters-1090	36	4	genes	gene	NOUN
brainmatters-1090	36	5	that	that	PRON
brainmatters-1090	36	6	regulate	regulate	VERB
brainmatters-1090	36	7	cell	cell	NOUN
brainmatters-1090	36	8	growth	growth	NOUN
brainmatters-1090	36	9	in	in	ADP
brainmatters-1090	36	10	order	order	NOUN
brainmatters-1090	36	11	to	to	PART
brainmatters-1090	36	12	prevent	prevent	VERB
brainmatters-1090	36	13	the	the	DET
brainmatters-1090	36	14	development	development	NOUN
brainmatters-1090	36	15	of	of	ADP
brainmatters-1090	36	16	cancer	cancer	NOUN
brainmatters-1090	36	17	.	.	PUNCT
brainmatters-1090	37	1	without	without	ADP
brainmatters-1090	37	2	them	they	PRON
brainmatters-1090	37	3	,	,	PUNCT
brainmatters-1090	37	4	cells	cell	NOUN
brainmatters-1090	37	5	will	will	AUX
brainmatters-1090	37	6	not	not	PART
brainmatters-1090	37	7	perform	perform	VERB
brainmatters-1090	37	8	apoptosis	apoptosis	NOUN
brainmatters-1090	37	9	and	and	CCONJ
brainmatters-1090	37	10	instead	instead	ADV
brainmatters-1090	37	11	continuously	continuously	ADV
brainmatters-1090	37	12	divide	divide	VERB
brainmatters-1090	37	13	uncontrollably	uncontrollably	ADV
brainmatters-1090	37	14	.	.	PUNCT
brainmatters-1090	38	1	tumor	tumor	NOUN
brainmatters-1090	38	2	suppressors	suppressor	NOUN
brainmatters-1090	38	3	such	such	ADJ
brainmatters-1090	38	4	as	as	ADP
brainmatters-1090	38	5	ren(kctd11	ren(kctd11	PROPN
brainmatters-1090	38	6	)	)	PUNCT
brainmatters-1090	38	7	,	,	PUNCT
brainmatters-1090	38	8	numb	numb	ADJ
brainmatters-1090	38	9	,	,	PUNCT
brainmatters-1090	38	10	and	and	CCONJ
brainmatters-1090	38	11	p53	p53	NOUN
brainmatters-1090	38	12	have	have	VERB
brainmatters-1090	38	13	suppressive	suppressive	ADJ
brainmatters-1090	38	14	effects	effect	NOUN
brainmatters-1090	38	15	on	on	ADP
brainmatters-1090	38	16	gli	gli	ADJ
brainmatters-1090	38	17	-	-	ADJ
brainmatters-1090	38	18	dependent	dependent	ADJ
brainmatters-1090	38	19	activation	activation	NOUN
brainmatters-1090	38	20	of	of	ADP
brainmatters-1090	38	21	hh	hh	PROPN
brainmatters-1090	38	22	target	target	NOUN
brainmatters-1090	38	23	genes	gene	NOUN
brainmatters-1090	38	24	.	.	PUNCT
brainmatters-1090	39	1	the	the	DET
brainmatters-1090	39	2	activity	activity	NOUN
brainmatters-1090	39	3	of	of	ADP
brainmatters-1090	39	4	these	these	DET
brainmatters-1090	39	5	tumor	tumor	NOUN
brainmatters-1090	39	6	suppressors	suppressor	NOUN
brainmatters-1090	39	7	may	may	AUX
brainmatters-1090	39	8	decrease	decrease	VERB
brainmatters-1090	39	9	and	and	CCONJ
brainmatters-1090	39	10	lead	lead	VERB
brainmatters-1090	39	11	to	to	ADP
brainmatters-1090	39	12	unregulated	unregulated	ADJ
brainmatters-1090	39	13	glli	glli	NOUN
brainmatters-1090	39	14	protein	protein	NOUN
brainmatters-1090	39	15	activation	activation	NOUN
brainmatters-1090	39	16	,	,	PUNCT
brainmatters-1090	39	17	contributing	contribute	VERB
brainmatters-1090	39	18	to	to	ADP
brainmatters-1090	39	19	cancer	cancer	NOUN
brainmatters-1090	39	20	development	development	NOUN
brainmatters-1090	39	21	.	.	PUNCT
brainmatters-1090	40	1	figure	figure	NOUN
brainmatters-1090	40	2	2	2	NUM
brainmatters-1090	40	3	.	.	PUNCT
brainmatters-1090	41	1	medulloblastoma	medulloblastoma	NOUN
brainmatters-1090	41	2	subgroups	subgroup	NOUN
brainmatters-1090	41	3	and	and	CCONJ
brainmatters-1090	41	4	the	the	DET
brainmatters-1090	41	5	histological	histological	ADJ
brainmatters-1090	41	6	characteristics	characteristic	NOUN
brainmatters-1090	41	7	(	(	PUNCT
brainmatters-1090	41	8	cotter	cotter	PROPN
brainmatters-1090	41	9	&	&	CCONJ
brainmatters-1090	41	10	hawkins	hawkins	PROPN
brainmatters-1090	41	11	,	,	PUNCT
brainmatters-1090	41	12	2021	2021	NUM
brainmatters-1090	41	13	)	)	PUNCT
brainmatters-1090	41	14	.	.	PUNCT
brainmatters-1090	42	1	research	research	NOUN
brainmatters-1090	42	2	for	for	ADP
brainmatters-1090	42	3	improvement	improvement	NOUN
brainmatters-1090	42	4	and	and	CCONJ
brainmatters-1090	42	5	treatments	treatment	VERB
brainmatters-1090	42	6	the	the	DET
brainmatters-1090	42	7	findings	finding	NOUN
brainmatters-1090	42	8	of	of	ADP
brainmatters-1090	42	9	how	how	SCONJ
brainmatters-1090	42	10	the	the	DET
brainmatters-1090	42	11	hh	hh	ADJ
brainmatters-1090	42	12	signaling	signal	VERB
brainmatters-1090	42	13	pathway	pathway	NOUN
brainmatters-1090	42	14	works	work	NOUN
brainmatters-1090	42	15	and	and	CCONJ
brainmatters-1090	42	16	its	its	PRON
brainmatters-1090	42	17	involvement	involvement	NOUN
brainmatters-1090	42	18	in	in	ADP
brainmatters-1090	42	19	tumorigenesis	tumorigenesis	NOUN
brainmatters-1090	42	20	have	have	AUX
brainmatters-1090	42	21	opened	open	VERB
brainmatters-1090	42	22	up	up	ADP
brainmatters-1090	42	23	the	the	DET
brainmatters-1090	42	24	possibilities	possibility	NOUN
brainmatters-1090	42	25	of	of	ADP
brainmatters-1090	42	26	developing	develop	VERB
brainmatters-1090	42	27	methods	method	NOUN
brainmatters-1090	42	28	of	of	ADP
brainmatters-1090	42	29	molecular	molecular	ADJ
brainmatters-1090	42	30	targeting	targeting	NOUN
brainmatters-1090	42	31	and	and	CCONJ
brainmatters-1090	42	32	tumor	tumor	NOUN
brainmatters-1090	42	33	prevention	prevention	NOUN
brainmatters-1090	42	34	associated	associate	VERB
brainmatters-1090	42	35	with	with	ADP
brainmatters-1090	42	36	the	the	DET
brainmatters-1090	42	37	pathway	pathway	NOUN
brainmatters-1090	42	38	.	.	PUNCT
brainmatters-1090	43	1	several	several	ADJ
brainmatters-1090	43	2	studies	study	NOUN
brainmatters-1090	43	3	support	support	VERB
brainmatters-1090	43	4	the	the	DET
brainmatters-1090	43	5	hypothesis	hypothesis	NOUN
brainmatters-1090	43	6	that	that	PRON
brainmatters-1090	43	7	malignant	malignant	ADJ
brainmatters-1090	43	8	tumors	tumor	NOUN
brainmatters-1090	43	9	are	be	AUX
brainmatters-1090	43	10	initiated	initiate	VERB
brainmatters-1090	43	11	and	and	CCONJ
brainmatters-1090	43	12	maintained	maintain	VERB
brainmatters-1090	43	13	by	by	ADP
brainmatters-1090	43	14	cancer	cancer	NOUN
brainmatters-1090	43	15	stem	stem	NOUN
brainmatters-1090	43	16	cells	cell	NOUN
brainmatters-1090	43	17	(	(	PUNCT
brainmatters-1090	43	18	tan	tan	NOUN
brainmatters-1090	43	19	et	et	PROPN
brainmatters-1090	43	20	al	al	PROPN
brainmatters-1090	43	21	.	.	PROPN
brainmatters-1090	43	22	,	,	PUNCT
brainmatters-1090	43	23	2006	2006	NUM
brainmatters-1090	43	24	;	;	PUNCT
brainmatters-1090	43	25	xie	xie	PROPN
brainmatters-1090	43	26	et	et	PROPN
brainmatters-1090	43	27	al	al	PROPN
brainmatters-1090	43	28	.	.	PROPN
brainmatters-1090	43	29	,	,	PUNCT
brainmatters-1090	43	30	2022	2022	NUM
brainmatters-1090	43	31	)	)	PUNCT
brainmatters-1090	43	32	.	.	PUNCT
brainmatters-1090	44	1	specific	specific	ADJ
brainmatters-1090	44	2	neuronal	neuronal	ADJ
brainmatters-1090	44	3	cancer	cancer	NOUN
brainmatters-1090	44	4	stem	stem	NOUN
brainmatters-1090	44	5	cells	cell	NOUN
brainmatters-1090	44	6	can	can	AUX
brainmatters-1090	44	7	be	be	AUX
brainmatters-1090	44	8	found	find	VERB
brainmatters-1090	44	9	in	in	ADP
brainmatters-1090	44	10	a	a	DET
brainmatters-1090	44	11	niche	niche	NOUN
brainmatters-1090	44	12	,	,	PUNCT
brainmatters-1090	44	13	where	where	SCONJ
brainmatters-1090	44	14	neurons	neuron	NOUN
brainmatters-1090	44	15	and	and	CCONJ
brainmatters-1090	44	16	glial	glial	ADJ
brainmatters-1090	44	17	cells	cell	NOUN
brainmatters-1090	44	18	are	be	AUX
brainmatters-1090	44	19	generated	generate	VERB
brainmatters-1090	44	20	from	from	ADP
brainmatters-1090	44	21	stem	stem	NOUN
brainmatters-1090	44	22	cells	cell	NOUN
brainmatters-1090	44	23	or	or	CCONJ
brainmatters-1090	44	24	progenitor	progenitor	NOUN
brainmatters-1090	44	25	cells	cell	NOUN
brainmatters-1090	44	26	.	.	PUNCT
brainmatters-1090	45	1	the	the	DET
brainmatters-1090	45	2	niche	niche	NOUN
brainmatters-1090	45	3	provides	provide	VERB
brainmatters-1090	45	4	signals	signal	NOUN
brainmatters-1090	45	5	that	that	PRON
brainmatters-1090	45	6	regulate	regulate	VERB
brainmatters-1090	45	7	whether	whether	SCONJ
brainmatters-1090	45	8	the	the	DET
brainmatters-1090	45	9	stem	stem	NOUN
brainmatters-1090	45	10	cells	cell	NOUN
brainmatters-1090	45	11	should	should	AUX
brainmatters-1090	45	12	differentiate	differentiate	VERB
brainmatters-1090	45	13	,	,	PUNCT
brainmatters-1090	45	14	remain	remain	VERB
brainmatters-1090	45	15	dormant	dormant	ADJ
brainmatters-1090	45	16	,	,	PUNCT
brainmatters-1090	45	17	or	or	CCONJ
brainmatters-1090	45	18	actively	actively	ADV
brainmatters-1090	45	19	divide	divide	VERB
brainmatters-1090	45	20	.	.	PUNCT
brainmatters-1090	46	1	shh	shh	NOUN
brainmatters-1090	46	2	is	be	AUX
brainmatters-1090	46	3	very	very	ADV
brainmatters-1090	46	4	important	important	ADJ
brainmatters-1090	46	5	for	for	ADP
brainmatters-1090	46	6	determining	determine	VERB
brainmatters-1090	46	7	cell	cell	NOUN
brainmatters-1090	46	8	fate	fate	NOUN
brainmatters-1090	46	9	and	and	CCONJ
brainmatters-1090	46	10	patterning	pattern	VERB
brainmatters-1090	46	11	during	during	ADP
brainmatters-1090	46	12	embryo	embryo	NOUN
brainmatters-1090	46	13	development	development	NOUN
brainmatters-1090	46	14	.	.	PUNCT
brainmatters-1090	47	1	it	it	PRON
brainmatters-1090	47	2	was	be	AUX
brainmatters-1090	47	3	discovered	discover	VERB
brainmatters-1090	47	4	that	that	SCONJ
brainmatters-1090	47	5	the	the	DET
brainmatters-1090	47	6	level	level	NOUN
brainmatters-1090	47	7	of	of	ADP
brainmatters-1090	47	8	shh	shh	NOUN
brainmatters-1090	47	9	signaling	signal	VERB
brainmatters-1090	47	10	pathway	pathway	NOUN
brainmatters-1090	47	11	activation	activation	NOUN
brainmatters-1090	47	12	in	in	ADP
brainmatters-1090	47	13	adulthood	adulthood	PROPN
brainmatters-1090	47	14	played	play	VERB
brainmatters-1090	47	15	an	an	DET
brainmatters-1090	47	16	important	important	ADJ
brainmatters-1090	47	17	role	role	NOUN
brainmatters-1090	47	18	in	in	ADP
brainmatters-1090	47	19	regulating	regulate	VERB
brainmatters-1090	47	20	the	the	DET
brainmatters-1090	47	21	balance	balance	NOUN
brainmatters-1090	47	22	between	between	ADP
brainmatters-1090	47	23	dormant	dormant	ADJ
brainmatters-1090	47	24	and	and	CCONJ
brainmatters-1090	47	25	activated	activated	ADJ
brainmatters-1090	47	26	neuron	neuron	NOUN
brainmatters-1090	47	27	stem	stem	NOUN
brainmatters-1090	47	28	cells	cell	NOUN
brainmatters-1090	47	29	(	(	PUNCT
brainmatters-1090	47	30	carballo	carballo	NOUN
brainmatters-1090	47	31	et	et	NOUN
brainmatters-1090	47	32	al	al	PROPN
brainmatters-1090	47	33	.	.	PROPN
brainmatters-1090	47	34	,	,	PUNCT
brainmatters-1090	47	35	2018	2018	NUM
brainmatters-1090	47	36	)	)	PUNCT
brainmatters-1090	47	37	.	.	PUNCT
brainmatters-1090	48	1	currently	currently	ADV
brainmatters-1090	48	2	,	,	PUNCT
brainmatters-1090	48	3	the	the	DET
brainmatters-1090	48	4	standard	standard	ADJ
brainmatters-1090	48	5	treatment	treatment	NOUN
brainmatters-1090	48	6	for	for	ADP
brainmatters-1090	48	7	most	most	ADJ
brainmatters-1090	48	8	brain	brain	NOUN
brainmatters-1090	48	9	tumors	tumor	NOUN
brainmatters-1090	48	10	is	be	AUX
brainmatters-1090	48	11	the	the	DET
brainmatters-1090	48	12	removal	removal	NOUN
brainmatters-1090	48	13	of	of	ADP
brainmatters-1090	48	14	the	the	DET
brainmatters-1090	48	15	majority	majority	NOUN
brainmatters-1090	48	16	of	of	ADP
brainmatters-1090	48	17	the	the	DET
brainmatters-1090	48	18	tumor	tumor	NOUN
brainmatters-1090	48	19	,	,	PUNCT
brainmatters-1090	48	20	followed	follow	VERB
brainmatters-1090	48	21	by	by	ADP
brainmatters-1090	48	22	chemotherapy	chemotherapy	NOUN
brainmatters-1090	48	23	and	and	CCONJ
brainmatters-1090	48	24	radiotherapy	radiotherapy	NOUN
brainmatters-1090	48	25	.	.	PUNCT
brainmatters-1090	49	1	researchers	researcher	NOUN
brainmatters-1090	49	2	are	be	AUX
brainmatters-1090	49	3	currently	currently	ADV
brainmatters-1090	49	4	trying	try	VERB
brainmatters-1090	49	5	to	to	PART
brainmatters-1090	49	6	determine	determine	VERB
brainmatters-1090	49	7	alternative	alternative	ADJ
brainmatters-1090	49	8	treatments	treatment	NOUN
brainmatters-1090	49	9	involving	involve	VERB
brainmatters-1090	49	10	the	the	DET
brainmatters-1090	49	11	inhibition	inhibition	NOUN
brainmatters-1090	49	12	of	of	ADP
brainmatters-1090	49	13	the	the	DET
brainmatters-1090	49	14	shh	shh	PROPN
brainmatters-1090	49	15	pathway	pathway	NOUN
brainmatters-1090	49	16	activation	activation	NOUN
brainmatters-1090	49	17	in	in	ADP
brainmatters-1090	49	18	cancer	cancer	NOUN
brainmatters-1090	49	19	stem	stem	NOUN
brainmatters-1090	49	20	cells	cell	NOUN
brainmatters-1090	49	21	.	.	PUNCT
brainmatters-1090	50	1	there	there	PRON
brainmatters-1090	50	2	is	be	VERB
brainmatters-1090	50	3	great	great	ADJ
brainmatters-1090	50	4	interest	interest	NOUN
brainmatters-1090	50	5	in	in	ADP
brainmatters-1090	50	6	targeted	target	VERB
brainmatters-1090	50	7	hh	hh	NOUN
brainmatters-1090	50	8	signaling	signal	VERB
brainmatters-1090	50	9	pathway	pathway	NOUN
brainmatters-1090	50	10	inhibition	inhibition	NOUN
brainmatters-1090	50	11	(	(	PUNCT
brainmatters-1090	50	12	hpi	hpi	NOUN
brainmatters-1090	50	13	)	)	PUNCT
brainmatters-1090	50	14	as	as	ADP
brainmatters-1090	50	15	a	a	DET
brainmatters-1090	50	16	type	type	NOUN
brainmatters-1090	50	17	of	of	ADP
brainmatters-1090	50	18	treatment	treatment	NOUN
brainmatters-1090	50	19	for	for	ADP
brainmatters-1090	50	20	aggressive	aggressive	ADJ
brainmatters-1090	50	21	cancer	cancer	NOUN
brainmatters-1090	50	22	cells	cell	NOUN
brainmatters-1090	50	23	when	when	SCONJ
brainmatters-1090	50	24	radiotherapy	radiotherapy	NOUN
brainmatters-1090	50	25	and	and	CCONJ
brainmatters-1090	50	26	surgery	surgery	NOUN
brainmatters-1090	50	27	are	be	AUX
brainmatters-1090	50	28	not	not	PART
brainmatters-1090	50	29	effective	effective	ADJ
brainmatters-1090	50	30	(	(	PUNCT
brainmatters-1090	50	31	skoda	skoda	PROPN
brainmatters-1090	50	32	et	et	PROPN
brainmatters-1090	50	33	al	al	PROPN
brainmatters-1090	50	34	.	.	PROPN
brainmatters-1090	50	35	,	,	PUNCT
brainmatters-1090	50	36	2018	2018	NUM
brainmatters-1090	50	37	)	)	PUNCT
brainmatters-1090	50	38	.	.	PUNCT
brainmatters-1090	51	1	there	there	PRON
brainmatters-1090	51	2	have	have	AUX
brainmatters-1090	51	3	been	be	AUX
brainmatters-1090	51	4	multiple	multiple	ADJ
brainmatters-1090	51	5	hpi	hpi	NOUN
brainmatters-1090	51	6	molecules	molecule	NOUN
brainmatters-1090	51	7	identified	identify	VERB
brainmatters-1090	51	8	that	that	DET
brainmatters-1090	51	9	act	act	NOUN
brainmatters-1090	51	10	at	at	ADP
brainmatters-1090	51	11	different	different	ADJ
brainmatters-1090	51	12	levels	level	NOUN
brainmatters-1090	51	13	of	of	ADP
brainmatters-1090	51	14	the	the	DET
brainmatters-1090	51	15	hh	hh	ADJ
brainmatters-1090	51	16	pathway	pathway	NOUN
brainmatters-1090	51	17	.	.	PUNCT
brainmatters-1090	52	1	one	one	NUM
brainmatters-1090	52	2	group	group	NOUN
brainmatters-1090	52	3	is	be	AUX
brainmatters-1090	52	4	hh	hh	PROPN
brainmatters-1090	52	5	ligand	ligand	NOUN
brainmatters-1090	52	6	inhibitors	inhibitor	NOUN
brainmatters-1090	52	7	,	,	PUNCT
brainmatters-1090	52	8	hpis	hpis	NOUN
brainmatters-1090	52	9	that	that	PRON
brainmatters-1090	52	10	inhibit	inhibit	VERB
brainmatters-1090	52	11	the	the	DET
brainmatters-1090	52	12	binding	binding	NOUN
brainmatters-1090	52	13	of	of	ADP
brainmatters-1090	52	14	the	the	DET
brainmatters-1090	52	15	hh	hh	ADJ
brainmatters-1090	52	16	protein	protein	NOUN
brainmatters-1090	52	17	to	to	PART
brainmatters-1090	52	18	ptch	ptch	VERB
brainmatters-1090	52	19	receptors	receptor	NOUN
brainmatters-1090	52	20	,	,	PUNCT
brainmatters-1090	52	21	keeping	keep	VERB
brainmatters-1090	52	22	smo	smo	NOUN
brainmatters-1090	52	23	inhibited	inhibited	ADJ
brainmatters-1090	52	24	and	and	CCONJ
brainmatters-1090	52	25	therefore	therefore	ADV
brainmatters-1090	52	26	the	the	DET
brainmatters-1090	52	27	rest	rest	NOUN
brainmatters-1090	52	28	of	of	ADP
brainmatters-1090	52	29	the	the	DET
brainmatters-1090	52	30	pathway	pathway	NOUN
brainmatters-1090	52	31	blocked	block	VERB
brainmatters-1090	52	32	from	from	ADP
brainmatters-1090	52	33	activating	activate	VERB
brainmatters-1090	52	34	target	target	NOUN
brainmatters-1090	52	35	genes	gene	NOUN
brainmatters-1090	52	36	.	.	PUNCT
brainmatters-1090	53	1	this	this	PRON
brainmatters-1090	53	2	includes	include	VERB
brainmatters-1090	53	3	cyclopamine	cyclopamine	PROPN
brainmatters-1090	53	4	,	,	PUNCT
brainmatters-1090	53	5	vismodegib	vismodegib	NOUN
brainmatters-1090	53	6	,	,	PUNCT
brainmatters-1090	53	7	and	and	CCONJ
brainmatters-1090	53	8	sonidegib	sonidegib	NOUN
brainmatters-1090	53	9	.	.	PUNCT
brainmatters-1090	54	1	another	another	DET
brainmatters-1090	54	2	group	group	NOUN
brainmatters-1090	54	3	is	be	AUX
brainmatters-1090	54	4	smo	smo	NOUN
brainmatters-1090	54	5	antagonists	antagonist	NOUN
brainmatters-1090	54	6	which	which	PRON
brainmatters-1090	54	7	bind	bind	VERB
brainmatters-1090	54	8	to	to	ADP
brainmatters-1090	54	9	a	a	DET
brainmatters-1090	54	10	specific	specific	ADJ
brainmatters-1090	54	11	site	site	NOUN
brainmatters-1090	54	12	on	on	ADP
brainmatters-1090	54	13	the	the	DET
brainmatters-1090	54	14	smo	smo	PROPN
brainmatters-1090	54	15	receptor	receptor	NOUN
brainmatters-1090	54	16	that	that	PRON
brainmatters-1090	54	17	prevents	prevent	VERB
brainmatters-1090	54	18	the	the	DET
brainmatters-1090	54	19	downstream	downstream	ADJ
brainmatters-1090	54	20	activation	activation	NOUN
brainmatters-1090	54	21	of	of	ADP
brainmatters-1090	54	22	the	the	DET
brainmatters-1090	54	23	hh	hh	PROPN
brainmatters-1090	54	24	signaling	signal	VERB
brainmatters-1090	54	25	cascade	cascade	NOUN
brainmatters-1090	54	26	.	.	PUNCT
brainmatters-1090	55	1	however	however	ADV
brainmatters-1090	55	2	,	,	PUNCT
brainmatters-1090	55	3	clinical	clinical	ADJ
brainmatters-1090	55	4	studies	study	NOUN
brainmatters-1090	55	5	have	have	AUX
brainmatters-1090	55	6	shown	show	VERB
brainmatters-1090	55	7	that	that	SCONJ
brainmatters-1090	55	8	the	the	DET
brainmatters-1090	55	9	use	use	NOUN
brainmatters-1090	55	10	of	of	ADP
brainmatters-1090	55	11	smo	smo	PROPN
brainmatters-1090	55	12	inhibitors	inhibitor	NOUN
brainmatters-1090	55	13	can	can	AUX
brainmatters-1090	55	14	induce	induce	VERB
brainmatters-1090	55	15	development	development	NOUN
brainmatters-1090	55	16	of	of	ADP
brainmatters-1090	55	17	mutations	mutation	NOUN
brainmatters-1090	55	18	that	that	PRON
brainmatters-1090	55	19	lead	lead	VERB
brainmatters-1090	55	20	to	to	ADP
brainmatters-1090	55	21	treatment	treatment	NOUN
brainmatters-1090	55	22	resistance	resistance	NOUN
brainmatters-1090	55	23	.	.	PUNCT
brainmatters-1090	56	1	moreover	moreover	ADV
brainmatters-1090	56	2	,	,	PUNCT
brainmatters-1090	56	3	shh	shh	PROPN
brainmatters-1090	56	4	medulloblastomas	medulloblastoma	NOUN
brainmatters-1090	56	5	are	be	AUX
brainmatters-1090	56	6	highly	highly	ADV
brainmatters-1090	56	7	mutated	mutate	VERB
brainmatters-1090	56	8	tumors	tumor	NOUN
brainmatters-1090	56	9	,	,	PUNCT
brainmatters-1090	56	10	and	and	CCONJ
brainmatters-1090	56	11	it	it	PRON
brainmatters-1090	56	12	is	be	AUX
brainmatters-1090	56	13	not	not	PART
brainmatters-1090	56	14	uncommon	uncommon	ADJ
brainmatters-1090	56	15	for	for	SCONJ
brainmatters-1090	56	16	these	these	DET
brainmatters-1090	56	17	tumors	tumor	NOUN
brainmatters-1090	56	18	to	to	PART
brainmatters-1090	56	19	develop	develop	VERB
brainmatters-1090	56	20	a	a	DET
brainmatters-1090	56	21	resistance	resistance	NOUN
brainmatters-1090	56	22	to	to	ADP
brainmatters-1090	56	23	smo	smo	NOUN
brainmatters-1090	56	24	inhibition	inhibition	NOUN
brainmatters-1090	56	25	,	,	PUNCT
brainmatters-1090	56	26	as	as	SCONJ
brainmatters-1090	56	27	they	they	PRON
brainmatters-1090	56	28	present	present	VERB
brainmatters-1090	56	29	alterations	alteration	NOUN
brainmatters-1090	56	30	in	in	ADP
brainmatters-1090	56	31	downstream	downstream	ADJ
brainmatters-1090	57	1	shh	shh	PROPN
brainmatters-1090	57	2	pathway	pathway	NOUN
brainmatters-1090	57	3	genes	gene	NOUN
brainmatters-1090	57	4	such	such	ADJ
brainmatters-1090	57	5	as	as	ADP
brainmatters-1090	57	6	sufu	sufu	NOUN
brainmatters-1090	57	7	and	and	CCONJ
brainmatters-1090	57	8	gli2	gli2	PROPN
brainmatters-1090	57	9	.	.	PUNCT
brainmatters-1090	58	1	this	this	PRON
brainmatters-1090	58	2	turned	turn	VERB
brainmatters-1090	58	3	researchers	researcher	NOUN
brainmatters-1090	58	4	to	to	ADP
brainmatters-1090	58	5	gli	gli	NOUN
brainmatters-1090	58	6	-	-	PUNCT
brainmatters-1090	58	7	based	base	VERB
brainmatters-1090	58	8	inhibitors	inhibitor	NOUN
brainmatters-1090	58	9	,	,	PUNCT
brainmatters-1090	58	10	which	which	PRON
brainmatters-1090	58	11	is	be	AUX
brainmatters-1090	58	12	an	an	DET
brainmatters-1090	58	13	alternative	alternative	ADJ
brainmatters-1090	58	14	group	group	NOUN
brainmatters-1090	58	15	of	of	ADP
brainmatters-1090	58	16	shh	shh	PROPN
brainmatters-1090	58	17	antagonists	antagonist	NOUN
brainmatters-1090	58	18	that	that	PRON
brainmatters-1090	58	19	act	act	VERB
brainmatters-1090	58	20	directly	directly	ADV
brainmatters-1090	58	21	in	in	ADP
brainmatters-1090	58	22	gli	gli	NOUN
brainmatters-1090	58	23	to	to	PART
brainmatters-1090	58	24	block	block	VERB
brainmatters-1090	58	25	transcription	transcription	NOUN
brainmatters-1090	58	26	factors	factor	NOUN
brainmatters-1090	58	27	.	.	PUNCT
brainmatters-1090	59	1	this	this	PRON
brainmatters-1090	59	2	includes	include	VERB
brainmatters-1090	59	3	nvplde-225	nvplde-225	NOUN
brainmatters-1090	59	4	and	and	CCONJ
brainmatters-1090	59	5	bms833923	bms833923	NOUN
brainmatters-1090	59	6	,	,	PUNCT
brainmatters-1090	59	7	which	which	PRON
brainmatters-1090	59	8	are	be	AUX
brainmatters-1090	59	9	currently	currently	ADV
brainmatters-1090	59	10	being	be	AUX
brainmatters-1090	59	11	tested	test	VERB
brainmatters-1090	59	12	in	in	ADP
brainmatters-1090	59	13	brain	brain	NOUN
brainmatters-1090	59	14	tumors	tumor	NOUN
brainmatters-1090	59	15	(	(	PUNCT
brainmatters-1090	59	16	carballo	carballo	VERB
brainmatters-1090	59	17	et	et	NOUN
brainmatters-1090	59	18	al	al	PROPN
brainmatters-1090	59	19	.	.	PROPN
brainmatters-1090	59	20	,	,	PUNCT
brainmatters-1090	59	21	2018	2018	NUM
brainmatters-1090	59	22	)	)	PUNCT
brainmatters-1090	59	23	.	.	PUNCT
brainmatters-1090	60	1	while	while	SCONJ
brainmatters-1090	60	2	most	most	ADJ
brainmatters-1090	60	3	of	of	ADP
brainmatters-1090	60	4	the	the	DET
brainmatters-1090	60	5	hpis	hpis	NOUN
brainmatters-1090	60	6	that	that	PRON
brainmatters-1090	60	7	have	have	AUX
brainmatters-1090	60	8	entered	enter	VERB
brainmatters-1090	60	9	clinical	clinical	ADJ
brainmatters-1090	60	10	trials	trial	NOUN
brainmatters-1090	60	11	mainly	mainly	ADV
brainmatters-1090	60	12	target	target	VERB
brainmatters-1090	60	13	smo	smo	PROPN
brainmatters-1090	60	14	,	,	PUNCT
brainmatters-1090	60	15	the	the	DET
brainmatters-1090	60	16	resistance	resistance	NOUN
brainmatters-1090	60	17	to	to	ADP
brainmatters-1090	60	18	these	these	DET
brainmatters-1090	60	19	inhibitors	inhibitor	NOUN
brainmatters-1090	60	20	have	have	AUX
brainmatters-1090	60	21	lead	lead	VERB
brainmatters-1090	60	22	to	to	ADP
brainmatters-1090	60	23	the	the	DET
brainmatters-1090	60	24	discovery	discovery	NOUN
brainmatters-1090	60	25	of	of	ADP
brainmatters-1090	60	26	new	new	ADJ
brainmatters-1090	60	27	hpis	hpis	NOUN
brainmatters-1090	60	28	that	that	PRON
brainmatters-1090	60	29	may	may	AUX
brainmatters-1090	60	30	be	be	AUX
brainmatters-1090	60	31	essential	essential	ADJ
brainmatters-1090	60	32	to	to	PART
brainmatters-1090	60	33	bypass	bypass	VERB
brainmatters-1090	60	34	these	these	DET
brainmatters-1090	60	35	resistance	resistance	NOUN
brainmatters-1090	60	36	mechanisms	mechanism	NOUN
brainmatters-1090	60	37	and	and	CCONJ
brainmatters-1090	60	38	control	control	VERB
brainmatters-1090	60	39	the	the	DET
brainmatters-1090	60	40	tumorigenesis	tumorigenesis	NOUN
brainmatters-1090	60	41	of	of	ADP
brainmatters-1090	60	42	medulloblastoma	medulloblastoma	NOUN
brainmatters-1090	60	43	.	.	PUNCT
brainmatters-1090	61	1	a	a	DET
brainmatters-1090	61	2	gateway	gateway	NOUN
brainmatters-1090	61	3	into	into	ADP
brainmatters-1090	61	4	the	the	DET
brainmatters-1090	61	5	future	future	NOUN
brainmatters-1090	61	6	the	the	DET
brainmatters-1090	61	7	hh	hh	PROPN
brainmatters-1090	61	8	signaling	signal	VERB
brainmatters-1090	61	9	pathway	pathway	NOUN
brainmatters-1090	61	10	plays	play	VERB
brainmatters-1090	61	11	a	a	DET
brainmatters-1090	61	12	critical	critical	ADJ
brainmatters-1090	61	13	role	role	NOUN
brainmatters-1090	61	14	in	in	ADP
brainmatters-1090	61	15	healthy	healthy	ADJ
brainmatters-1090	61	16	embryonic	embryonic	ADJ
brainmatters-1090	61	17	development	development	NOUN
brainmatters-1090	61	18	,	,	PUNCT
brainmatters-1090	61	19	putting	put	VERB
brainmatters-1090	61	20	into	into	ADP
brainmatters-1090	61	21	action	action	NOUN
brainmatters-1090	61	22	a	a	DET
brainmatters-1090	61	23	multitude	multitude	NOUN
brainmatters-1090	61	24	of	of	ADP
brainmatters-1090	61	25	target	target	NOUN
brainmatters-1090	61	26	genes	gene	NOUN
brainmatters-1090	61	27	that	that	PRON
brainmatters-1090	61	28	are	be	AUX
brainmatters-1090	61	29	needed	need	VERB
brainmatters-1090	61	30	for	for	ADP
brainmatters-1090	61	31	the	the	DET
brainmatters-1090	61	32	initial	initial	ADJ
brainmatters-1090	61	33	stages	stage	NOUN
brainmatters-1090	61	34	of	of	ADP
brainmatters-1090	61	35	development	development	NOUN
brainmatters-1090	61	36	.	.	PUNCT
brainmatters-1090	62	1	there	there	PRON
brainmatters-1090	62	2	are	be	VERB
brainmatters-1090	62	3	many	many	ADJ
brainmatters-1090	62	4	steps	step	NOUN
brainmatters-1090	62	5	in	in	ADP
brainmatters-1090	62	6	the	the	DET
brainmatters-1090	62	7	transduction	transduction	NOUN
brainmatters-1090	62	8	pathway	pathway	NOUN
brainmatters-1090	62	9	leading	lead	VERB
brainmatters-1090	62	10	to	to	ADP
brainmatters-1090	62	11	expression	expression	NOUN
brainmatters-1090	62	12	of	of	ADP
brainmatters-1090	62	13	target	target	NOUN
brainmatters-1090	62	14	genes	gene	NOUN
brainmatters-1090	62	15	.	.	PUNCT
brainmatters-1090	63	1	mutations	mutation	NOUN
brainmatters-1090	63	2	that	that	PRON
brainmatters-1090	63	3	form	form	NOUN
brainmatters-1090	63	4	can	can	AUX
brainmatters-1090	63	5	cause	cause	VERB
brainmatters-1090	63	6	this	this	DET
brainmatters-1090	63	7	highly	highly	ADV
brainmatters-1090	63	8	regulated	regulated	ADJ
brainmatters-1090	63	9	pathway	pathway	NOUN
brainmatters-1090	63	10	to	to	PART
brainmatters-1090	63	11	either	either	CCONJ
brainmatters-1090	63	12	activate	activate	VERB
brainmatters-1090	63	13	uncontrollably	uncontrollably	ADV
brainmatters-1090	63	14	or	or	CCONJ
brainmatters-1090	63	15	become	become	VERB
brainmatters-1090	63	16	inhibited	inhibited	ADJ
brainmatters-1090	63	17	at	at	ADP
brainmatters-1090	63	18	the	the	DET
brainmatters-1090	63	19	wrong	wrong	ADJ
brainmatters-1090	63	20	times	time	NOUN
brainmatters-1090	63	21	.	.	PUNCT
brainmatters-1090	64	1	when	when	SCONJ
brainmatters-1090	64	2	this	this	PRON
brainmatters-1090	64	3	occurs	occur	VERB
brainmatters-1090	64	4	,	,	PUNCT
brainmatters-1090	64	5	continuous	continuous	ADJ
brainmatters-1090	64	6	and	and	CCONJ
brainmatters-1090	64	7	inappropriate	inappropriate	ADJ
brainmatters-1090	64	8	cell	cell	NOUN
brainmatters-1090	64	9	the	the	DET
brainmatters-1090	64	10	detrimental	detrimental	ADJ
brainmatters-1090	64	11	effects	effect	NOUN
brainmatters-1090	64	12	of	of	ADP
brainmatters-1090	64	13	aberrant	aberrant	ADJ
brainmatters-1090	64	14	regulation	regulation	NOUN
brainmatters-1090	64	15	on	on	ADP
brainmatters-1090	64	16	the	the	DET
brainmatters-1090	64	17	hedgehog	hedgehog	NOUN
brainmatters-1090	64	18	signaling	signal	VERB
brainmatters-1090	64	19	pathway	pathway	NOUN
brainmatters-1090	64	20	division	division	NOUN
brainmatters-1090	64	21	can	can	AUX
brainmatters-1090	64	22	lead	lead	VERB
brainmatters-1090	64	23	to	to	ADP
brainmatters-1090	64	24	the	the	DET
brainmatters-1090	64	25	rapid	rapid	ADJ
brainmatters-1090	64	26	growth	growth	NOUN
brainmatters-1090	64	27	of	of	ADP
brainmatters-1090	64	28	tumors	tumor	NOUN
brainmatters-1090	64	29	in	in	ADP
brainmatters-1090	64	30	the	the	DET
brainmatters-1090	64	31	body	body	NOUN
brainmatters-1090	64	32	.	.	PUNCT
brainmatters-1090	65	1	with	with	ADP
brainmatters-1090	65	2	the	the	DET
brainmatters-1090	65	3	knowledge	knowledge	NOUN
brainmatters-1090	65	4	that	that	PRON
brainmatters-1090	65	5	scientists	scientist	NOUN
brainmatters-1090	65	6	have	have	VERB
brainmatters-1090	65	7	today	today	NOUN
brainmatters-1090	65	8	about	about	ADP
brainmatters-1090	65	9	the	the	DET
brainmatters-1090	65	10	hh	hh	PROPN
brainmatters-1090	65	11	signaling	signal	VERB
brainmatters-1090	65	12	pathway	pathway	NOUN
brainmatters-1090	65	13	,	,	PUNCT
brainmatters-1090	65	14	there	there	PRON
brainmatters-1090	65	15	is	be	VERB
brainmatters-1090	65	16	great	great	ADJ
brainmatters-1090	65	17	potential	potential	NOUN
brainmatters-1090	65	18	for	for	ADP
brainmatters-1090	65	19	certain	certain	ADJ
brainmatters-1090	65	20	treatments	treatment	NOUN
brainmatters-1090	65	21	and	and	CCONJ
brainmatters-1090	65	22	therapies	therapy	NOUN
brainmatters-1090	65	23	that	that	PRON
brainmatters-1090	65	24	can	can	AUX
brainmatters-1090	65	25	inhibit	inhibit	VERB
brainmatters-1090	65	26	the	the	DET
brainmatters-1090	65	27	aberrant	aberrant	ADJ
brainmatters-1090	65	28	regulation	regulation	NOUN
brainmatters-1090	65	29	of	of	ADP
brainmatters-1090	65	30	the	the	DET
brainmatters-1090	65	31	hh	hh	ADJ
brainmatters-1090	65	32	pathway	pathway	NOUN
brainmatters-1090	65	33	,	,	PUNCT
brainmatters-1090	65	34	either	either	CCONJ
brainmatters-1090	65	35	from	from	ADP
brainmatters-1090	65	36	ligand	ligand	NOUN
brainmatters-1090	65	37	-	-	PUNCT
brainmatters-1090	65	38	dependent	dependent	ADJ
brainmatters-1090	65	39	or	or	CCONJ
brainmatters-1090	65	40	ligand	ligand	NOUN
brainmatters-1090	65	41	-	-	PUNCT
brainmatters-1090	65	42	independent	independent	ADJ
brainmatters-1090	65	43	signaling	signal	VERB
brainmatters-1090	65	44	inhibition	inhibition	NOUN
brainmatters-1090	65	45	.	.	PUNCT
brainmatters-1090	66	1	further	further	ADJ
brainmatters-1090	66	2	research	research	NOUN
brainmatters-1090	66	3	into	into	ADP
brainmatters-1090	66	4	which	which	PRON
brainmatters-1090	66	5	pathway	pathway	NOUN
brainmatters-1090	66	6	mechanisms	mechanism	NOUN
brainmatters-1090	66	7	are	be	AUX
brainmatters-1090	66	8	most	most	ADV
brainmatters-1090	66	9	likely	likely	ADJ
brainmatters-1090	66	10	to	to	PART
brainmatters-1090	66	11	elicit	elicit	VERB
brainmatters-1090	66	12	a	a	DET
brainmatters-1090	66	13	strong	strong	ADJ
brainmatters-1090	66	14	response	response	NOUN
brainmatters-1090	66	15	to	to	ADP
brainmatters-1090	66	16	inhibition	inhibition	NOUN
brainmatters-1090	66	17	can	can	AUX
brainmatters-1090	66	18	provide	provide	VERB
brainmatters-1090	66	19	a	a	DET
brainmatters-1090	66	20	greater	great	ADJ
brainmatters-1090	66	21	understanding	understanding	NOUN
brainmatters-1090	66	22	of	of	ADP
brainmatters-1090	66	23	the	the	DET
brainmatters-1090	66	24	hh	hh	ADJ
brainmatters-1090	66	25	pathway	pathway	NOUN
brainmatters-1090	66	26	,	,	PUNCT
brainmatters-1090	66	27	and	and	CCONJ
brainmatters-1090	66	28	can	can	AUX
brainmatters-1090	66	29	be	be	AUX
brainmatters-1090	66	30	used	use	VERB
brainmatters-1090	66	31	to	to	PART
brainmatters-1090	66	32	create	create	VERB
brainmatters-1090	66	33	better	well	ADJ
brainmatters-1090	66	34	,	,	PUNCT
brainmatters-1090	66	35	more	more	ADV
brainmatters-1090	66	36	effective	effective	ADJ
brainmatters-1090	66	37	,	,	PUNCT
brainmatters-1090	66	38	and	and	CCONJ
brainmatters-1090	66	39	safer	safe	ADJ
brainmatters-1090	66	40	anti	anti	ADJ
brainmatters-1090	66	41	-	-	ADJ
brainmatters-1090	66	42	cancer	cancer	ADJ
brainmatters-1090	66	43	therapies	therapy	NOUN
brainmatters-1090	66	44	.	.	PUNCT
brainmatters-1090	67	1	references	reference	NOUN
brainmatters-1090	67	2	1	1	NUM
brainmatters-1090	67	3	.	.	PUNCT
brainmatters-1090	67	4	carballo	carballo	PROPN
brainmatters-1090	67	5	,	,	PUNCT
brainmatters-1090	67	6	g.	g.	PROPN
brainmatters-1090	67	7	b.	b.	PROPN
brainmatters-1090	67	8	,	,	PUNCT
brainmatters-1090	67	9	honorato	honorato	PROPN
brainmatters-1090	67	10	,	,	PUNCT
brainmatters-1090	67	11	j.	j.	PROPN
brainmatters-1090	67	12	r.	r.	PROPN
brainmatters-1090	67	13	,	,	PUNCT
brainmatters-1090	67	14	de	de	PROPN
brainmatters-1090	67	15	lopes	lopes	PROPN
brainmatters-1090	67	16	,	,	PUNCT
brainmatters-1090	67	17	g.	g.	PROPN
brainmatters-1090	67	18	p.	p.	PROPN
brainmatters-1090	67	19	,	,	PUNCT
brainmatters-1090	67	20	&	&	CCONJ
brainmatters-1090	67	21	spohr	spohr	PROPN
brainmatters-1090	67	22	,	,	PUNCT
brainmatters-1090	67	23	t.	t.	PROPN
brainmatters-1090	67	24	c.	c.	PROPN
brainmatters-1090	67	25	(	(	PUNCT
brainmatters-1090	67	26	2018	2018	NUM
brainmatters-1090	67	27	)	)	PUNCT
brainmatters-1090	67	28	.	.	PUNCT
brainmatters-1090	68	1	a	a	DET
brainmatters-1090	68	2	highlight	highlight	NOUN
brainmatters-1090	68	3	on	on	ADP
brainmatters-1090	68	4	sonic	sonic	ADJ
brainmatters-1090	68	5	hedgehog	hedgehog	NOUN
brainmatters-1090	68	6	pathway	pathway	NOUN
brainmatters-1090	68	7	.	.	PUNCT
brainmatters-1090	69	1	cell	cell	NOUN
brainmatters-1090	69	2	communication	communication	NOUN
brainmatters-1090	69	3	and	and	CCONJ
brainmatters-1090	69	4	signaling	signal	VERB
brainmatters-1090	69	5	,	,	PUNCT
brainmatters-1090	69	6	16(1	16(1	NUM
brainmatters-1090	69	7	)	)	PUNCT
brainmatters-1090	69	8	.	.	PUNCT
brainmatters-1090	70	1	2	2	X
brainmatters-1090	70	2	.	.	X
brainmatters-1090	70	3	cotter	cotter	PROPN
brainmatters-1090	70	4	,	,	PUNCT
brainmatters-1090	70	5	j.	j.	PROPN
brainmatters-1090	70	6	a.	a.	PROPN
brainmatters-1090	70	7	,	,	PUNCT
brainmatters-1090	70	8	&	&	CCONJ
brainmatters-1090	70	9	hawkins	hawkins	PROPN
brainmatters-1090	70	10	,	,	PUNCT
brainmatters-1090	70	11	c.	c.	NOUN
brainmatters-1090	70	12	(	(	PUNCT
brainmatters-1090	70	13	2022	2022	NUM
brainmatters-1090	70	14	)	)	PUNCT
brainmatters-1090	70	15	.	.	PUNCT
brainmatters-1090	71	1	medulloblastoma	medulloblastoma	NOUN
brainmatters-1090	71	2	:	:	PUNCT
brainmatters-1090	71	3	who	who	PRON
brainmatters-1090	71	4	2021	2021	NUM
brainmatters-1090	71	5	and	and	CCONJ
brainmatters-1090	71	6	beyond	beyond	ADP
brainmatters-1090	71	7	.	.	PUNCT
brainmatters-1090	72	1	pediatric	pediatric	ADJ
brainmatters-1090	72	2	and	and	CCONJ
brainmatters-1090	72	3	developmental	developmental	ADJ
brainmatters-1090	72	4	pathology	pathology	NOUN
brainmatters-1090	72	5	,	,	PUNCT
brainmatters-1090	72	6	25(1	25(1	NUM
brainmatters-1090	72	7	)	)	PUNCT
brainmatters-1090	72	8	,	,	PUNCT
brainmatters-1090	72	9	23–33	23–33	NUM
brainmatters-1090	72	10	.	.	PUNCT
brainmatters-1090	73	1	3	3	X
brainmatters-1090	73	2	.	.	X
brainmatters-1090	73	3	gigante	gigante	PROPN
brainmatters-1090	73	4	,	,	PUNCT
brainmatters-1090	73	5	e.	e.	PROPN
brainmatters-1090	73	6	d.	d.	PROPN
brainmatters-1090	73	7	,	,	PUNCT
brainmatters-1090	73	8	&	&	CCONJ
brainmatters-1090	73	9	caspary	caspary	PROPN
brainmatters-1090	73	10	,	,	PUNCT
brainmatters-1090	73	11	t.	t.	PROPN
brainmatters-1090	73	12	(	(	PUNCT
brainmatters-1090	73	13	2020	2020	NUM
brainmatters-1090	73	14	)	)	PUNCT
brainmatters-1090	73	15	.	.	PUNCT
brainmatters-1090	74	1	signaling	signal	VERB
brainmatters-1090	74	2	in	in	ADP
brainmatters-1090	74	3	the	the	DET
brainmatters-1090	74	4	primary	primary	ADJ
brainmatters-1090	74	5	cilium	cilium	NOUN
brainmatters-1090	74	6	through	through	ADP
brainmatters-1090	74	7	the	the	DET
brainmatters-1090	74	8	lens	lens	NOUN
brainmatters-1090	74	9	of	of	ADP
brainmatters-1090	74	10	the	the	DET
brainmatters-1090	74	11	hedgehog	hedgehog	NOUN
brainmatters-1090	74	12	pathway	pathway	NOUN
brainmatters-1090	74	13	.	.	PUNCT
brainmatters-1090	75	1	wires	wire	VERB
brainmatters-1090	75	2	developmental	developmental	ADJ
brainmatters-1090	75	3	biology	biology	NOUN
brainmatters-1090	75	4	,	,	PUNCT
brainmatters-1090	75	5	9(6	9(6	NUM
brainmatters-1090	75	6	)	)	PUNCT
brainmatters-1090	75	7	.	.	PUNCT
brainmatters-1090	76	1	4	4	X
brainmatters-1090	76	2	.	.	X
brainmatters-1090	76	3	sasai	sasai	PROPN
brainmatters-1090	76	4	,	,	PUNCT
brainmatters-1090	76	5	n.	n.	NOUN
brainmatters-1090	76	6	,	,	PUNCT
brainmatters-1090	76	7	&	&	CCONJ
brainmatters-1090	76	8	briscoe	briscoe	PROPN
brainmatters-1090	76	9	,	,	PUNCT
brainmatters-1090	76	10	j.	j.	PROPN
brainmatters-1090	76	11	(	(	PUNCT
brainmatters-1090	76	12	2012	2012	NUM
brainmatters-1090	76	13	)	)	PUNCT
brainmatters-1090	76	14	.	.	PUNCT
brainmatters-1090	77	1	primary	primary	ADJ
brainmatters-1090	77	2	cilia	cilia	NOUN
brainmatters-1090	77	3	and	and	CCONJ
brainmatters-1090	77	4	graded	grade	VERB
brainmatters-1090	77	5	sonic	sonic	ADJ
brainmatters-1090	77	6	hedgehog	hedgehog	NOUN
brainmatters-1090	77	7	signaling	signal	VERB
brainmatters-1090	77	8	.	.	PUNCT
brainmatters-1090	78	1	wires	wire	NOUN
brainmatters-1090	78	2	developmental	developmental	ADJ
brainmatters-1090	78	3	biology	biology	NOUN
brainmatters-1090	78	4	,	,	PUNCT
brainmatters-1090	78	5	1(5	1(5	NUM
brainmatters-1090	78	6	)	)	PUNCT
brainmatters-1090	78	7	,	,	PUNCT
brainmatters-1090	78	8	753–772	753–772	NUM
brainmatters-1090	78	9	.	.	PUNCT
brainmatters-1090	78	10	https://doi.org/10.1002/wdev.43	https://doi.org/10.1002/wdev.43	PROPN
brainmatters-1090	78	11	5	5	NUM
brainmatters-1090	78	12	.	.	X
brainmatters-1090	78	13	skoda	skoda	PROPN
brainmatters-1090	78	14	,	,	PUNCT
brainmatters-1090	78	15	a.	a.	NOUN
brainmatters-1090	78	16	m.	m.	NOUN
brainmatters-1090	78	17	,	,	PUNCT
brainmatters-1090	78	18	simovic	simovic	PROPN
brainmatters-1090	78	19	,	,	PUNCT
brainmatters-1090	78	20	d.	d.	PROPN
brainmatters-1090	78	21	,	,	PUNCT
brainmatters-1090	78	22	karin	karin	PROPN
brainmatters-1090	78	23	,	,	PUNCT
brainmatters-1090	78	24	v.	v.	PROPN
brainmatters-1090	78	25	,	,	PUNCT
brainmatters-1090	78	26	kardum	kardum	PROPN
brainmatters-1090	78	27	,	,	PUNCT
brainmatters-1090	78	28	v.	v.	ADV
brainmatters-1090	78	29	,	,	PUNCT
brainmatters-1090	78	30	vranic	vranic	ADJ
brainmatters-1090	78	31	,	,	PUNCT
brainmatters-1090	78	32	s.	s.	PROPN
brainmatters-1090	78	33	,	,	PUNCT
brainmatters-1090	78	34	&	&	CCONJ
brainmatters-1090	78	35	serman	serman	PROPN
brainmatters-1090	78	36	,	,	PUNCT
brainmatters-1090	78	37	l.	l.	PROPN
brainmatters-1090	78	38	(	(	PUNCT
brainmatters-1090	78	39	2018	2018	NUM
brainmatters-1090	78	40	)	)	PUNCT
brainmatters-1090	78	41	.	.	PUNCT
brainmatters-1090	79	1	the	the	DET
brainmatters-1090	79	2	role	role	NOUN
brainmatters-1090	79	3	of	of	ADP
brainmatters-1090	79	4	the	the	DET
brainmatters-1090	79	5	hedgehog	hedgehog	NOUN
brainmatters-1090	79	6	signaling	signal	VERB
brainmatters-1090	79	7	pathway	pathway	NOUN
brainmatters-1090	79	8	in	in	ADP
brainmatters-1090	79	9	cancer	cancer	NOUN
brainmatters-1090	79	10	:	:	PUNCT
brainmatters-1090	79	11	a	a	DET
brainmatters-1090	79	12	comprehensive	comprehensive	ADJ
brainmatters-1090	79	13	review	review	NOUN
brainmatters-1090	79	14	.	.	PUNCT
brainmatters-1090	80	1	bosnian	bosnian	ADJ
brainmatters-1090	80	2	journal	journal	PROPN
brainmatters-1090	80	3	of	of	ADP
brainmatters-1090	80	4	basic	basic	ADJ
brainmatters-1090	80	5	medical	medical	ADJ
brainmatters-1090	80	6	sciences	science	NOUN
brainmatters-1090	80	7	,	,	PUNCT
brainmatters-1090	80	8	18(1	18(1	NUM
brainmatters-1090	80	9	)	)	PUNCT
brainmatters-1090	80	10	,	,	PUNCT
brainmatters-1090	80	11	8–20	8–20	NOUN
brainmatters-1090	80	12	.	.	NOUN
brainmatters-1090	81	1	6	6	NUM
brainmatters-1090	81	2	.	.	X
brainmatters-1090	81	3	tan	tan	PROPN
brainmatters-1090	81	4	,	,	PUNCT
brainmatters-1090	81	5	b.	b.	PROPN
brainmatters-1090	81	6	t.	t.	PROPN
brainmatters-1090	81	7	,	,	PUNCT
brainmatters-1090	81	8	park	park	NOUN
brainmatters-1090	81	9	,	,	PUNCT
brainmatters-1090	81	10	c.	c.	PROPN
brainmatters-1090	81	11	y.	y.	PROPN
brainmatters-1090	81	12	,	,	PUNCT
brainmatters-1090	81	13	ailles	aille	NOUN
brainmatters-1090	81	14	,	,	PUNCT
brainmatters-1090	81	15	l.	l.	PROPN
brainmatters-1090	81	16	e.	e.	PROPN
brainmatters-1090	81	17	,	,	PUNCT
brainmatters-1090	81	18	&	&	CCONJ
brainmatters-1090	81	19	weissman	weissman	PROPN
brainmatters-1090	81	20	,	,	PUNCT
brainmatters-1090	81	21	i.	i.	PROPN
brainmatters-1090	81	22	l.	l.	PROPN
brainmatters-1090	81	23	(	(	PUNCT
brainmatters-1090	81	24	2006	2006	NUM
brainmatters-1090	81	25	)	)	PUNCT
brainmatters-1090	81	26	.	.	PUNCT
brainmatters-1090	82	1	the	the	DET
brainmatters-1090	82	2	cancer	cancer	NOUN
brainmatters-1090	82	3	stem	stem	NOUN
brainmatters-1090	82	4	cell	cell	NOUN
brainmatters-1090	82	5	hypothesis	hypothesis	NOUN
brainmatters-1090	82	6	:	:	PUNCT
brainmatters-1090	82	7	a	a	DET
brainmatters-1090	82	8	work	work	NOUN
brainmatters-1090	82	9	in	in	ADP
brainmatters-1090	82	10	progress	progress	NOUN
brainmatters-1090	82	11	.	.	PUNCT
brainmatters-1090	83	1	laboratory	laboratory	NOUN
brainmatters-1090	83	2	investigation	investigation	NOUN
brainmatters-1090	83	3	,	,	PUNCT
brainmatters-1090	83	4	86(12	86(12	NUM
brainmatters-1090	83	5	)	)	PUNCT
brainmatters-1090	83	6	,	,	PUNCT
brainmatters-1090	83	7	1203–1207	1203–1207	NUM
brainmatters-1090	83	8	.	.	PUNCT
brainmatters-1090	84	1	7	7	X
brainmatters-1090	84	2	.	.	X
brainmatters-1090	84	3	traiffort	traiffort	PROPN
brainmatters-1090	84	4	,	,	PUNCT
brainmatters-1090	84	5	e.	e.	PROPN
brainmatters-1090	84	6	,	,	PUNCT
brainmatters-1090	84	7	angot	angot	VERB
brainmatters-1090	84	8	,	,	PUNCT
brainmatters-1090	84	9	e.	e.	PROPN
brainmatters-1090	84	10	,	,	PUNCT
brainmatters-1090	84	11	&	&	CCONJ
brainmatters-1090	84	12	ruat	ruat	PROPN
brainmatters-1090	84	13	,	,	PUNCT
brainmatters-1090	84	14	m.	m.	NOUN
brainmatters-1090	84	15	(	(	PUNCT
brainmatters-1090	84	16	2010	2010	NUM
brainmatters-1090	84	17	)	)	PUNCT
brainmatters-1090	84	18	.	.	PUNCT
brainmatters-1090	85	1	sonic	sonic	ADJ
brainmatters-1090	85	2	hedgehog	hedgehog	NOUN
brainmatters-1090	85	3	signaling	signal	VERB
brainmatters-1090	85	4	in	in	ADP
brainmatters-1090	85	5	the	the	DET
brainmatters-1090	85	6	mammalian	mammalian	ADJ
brainmatters-1090	85	7	brain	brain	NOUN
brainmatters-1090	85	8	.	.	PUNCT
brainmatters-1090	86	1	journal	journal	PROPN
brainmatters-1090	86	2	of	of	ADP
brainmatters-1090	86	3	neurochemistry	neurochemistry	PROPN
brainmatters-1090	86	4	,	,	PUNCT
brainmatters-1090	86	5	113(3	113(3	NUM
brainmatters-1090	86	6	)	)	PUNCT
brainmatters-1090	86	7	,	,	PUNCT
brainmatters-1090	86	8	576–590	576–590	NUM
brainmatters-1090	86	9	.	.	PUNCT
brainmatters-1090	86	10	8	8	NUM
brainmatters-1090	86	11	.	.	X
brainmatters-1090	87	1	xie	xie	PROPN
brainmatters-1090	87	2	,	,	PUNCT
brainmatters-1090	87	3	x.	x.	PROPN
brainmatters-1090	87	4	p.	p.	PROPN
brainmatters-1090	87	5	,	,	PUNCT
brainmatters-1090	87	6	laks	laks	PROPN
brainmatters-1090	87	7	,	,	PUNCT
brainmatters-1090	87	8	d.	d.	PROPN
brainmatters-1090	87	9	r.	r.	PROPN
brainmatters-1090	87	10	,	,	PUNCT
brainmatters-1090	87	11	sun	sun	PROPN
brainmatters-1090	87	12	,	,	PUNCT
brainmatters-1090	87	13	d.	d.	PROPN
brainmatters-1090	87	14	,	,	PUNCT
brainmatters-1090	87	15	ganbold	ganbold	VERB
brainmatters-1090	87	16	,	,	PUNCT
brainmatters-1090	87	17	m.	m.	NOUN
brainmatters-1090	87	18	,	,	PUNCT
brainmatters-1090	87	19	wang	wang	PROPN
brainmatters-1090	87	20	,	,	PUNCT
brainmatters-1090	87	21	z.	z.	PROPN
brainmatters-1090	87	22	,	,	PUNCT
brainmatters-1090	87	23	pedraza	pedraza	PROPN
brainmatters-1090	87	24	,	,	PUNCT
brainmatters-1090	87	25	a.	a.	NOUN
brainmatters-1090	87	26	m.	m.	NOUN
brainmatters-1090	87	27	,	,	PUNCT
brainmatters-1090	87	28	bale	bale	NOUN
brainmatters-1090	87	29	,	,	PUNCT
brainmatters-1090	87	30	t.	t.	NOUN
brainmatters-1090	87	31	,	,	PUNCT
brainmatters-1090	87	32	tabar	tabar	NOUN
brainmatters-1090	87	33	,	,	PUNCT
brainmatters-1090	87	34	v.	v.	PROPN
brainmatters-1090	87	35	,	,	PUNCT
brainmatters-1090	87	36	brennan	brennan	PROPN
brainmatters-1090	87	37	,	,	PUNCT
brainmatters-1090	87	38	c.	c.	PROPN
brainmatters-1090	87	39	,	,	PUNCT
brainmatters-1090	87	40	zhou	zhou	PROPN
brainmatters-1090	87	41	,	,	PUNCT
brainmatters-1090	87	42	x.	x.	PROPN
brainmatters-1090	87	43	,	,	PUNCT
brainmatters-1090	87	44	&	&	CCONJ
brainmatters-1090	87	45	parada	parada	PROPN
brainmatters-1090	87	46	,	,	PUNCT
brainmatters-1090	87	47	l.	l.	PROPN
brainmatters-1090	87	48	f.	f.	PROPN
brainmatters-1090	87	49	(	(	PUNCT
brainmatters-1090	87	50	2022	2022	NUM
brainmatters-1090	87	51	)	)	PUNCT
brainmatters-1090	87	52	.	.	PUNCT
brainmatters-1090	88	1	quiescent	quiescent	ADJ
brainmatters-1090	88	2	human	human	ADJ
brainmatters-1090	88	3	glioblastoma	glioblastoma	NOUN
brainmatters-1090	88	4	cancer	cancer	NOUN
brainmatters-1090	88	5	stem	stem	NOUN
brainmatters-1090	88	6	cells	cell	NOUN
brainmatters-1090	88	7	drive	drive	VERB
brainmatters-1090	88	8	tumor	tumor	NOUN
brainmatters-1090	88	9	initiation	initiation	NOUN
brainmatters-1090	88	10	,	,	PUNCT
brainmatters-1090	88	11	expansion	expansion	NOUN
brainmatters-1090	88	12	,	,	PUNCT
brainmatters-1090	88	13	and	and	CCONJ
brainmatters-1090	88	14	recurrence	recurrence	NOUN
brainmatters-1090	88	15	following	follow	VERB
brainmatters-1090	88	16	chemotherapy	chemotherapy	NOUN
brainmatters-1090	88	17	.	.	PUNCT
brainmatters-1090	89	1	developmental	developmental	ADJ
brainmatters-1090	89	2	cell	cell	NOUN
brainmatters-1090	89	3	,	,	PUNCT
brainmatters-1090	89	4	57(1	57(1	NUM
brainmatters-1090	89	5	)	)	PUNCT
brainmatters-1090	89	6	.	.	PUNCT
brainmatters-1090	90	1	33	33	NUM
brainmatters-1090	90	2	brain	brain	NOUN
brainmatters-1090	90	3	matters	matter	NOUN
brainmatters-1090	90	4	vol	vol	NOUN
brainmatters-1090	90	5	.	.	PROPN
brainmatters-1090	90	6	8	8	NUM
brainmatters-1090	90	7	2025	2025	NUM
brainmatters-1090	90	8	34	34	NUM
brainmatters-1090	90	9	about	about	ADP
brainmatters-1090	90	10	the	the	DET
brainmatters-1090	90	11	author	author	NOUN
brainmatters-1090	90	12	emily	emily	PROPN
brainmatters-1090	90	13	aldrich	aldrich	PROPN
brainmatters-1090	90	14	is	be	AUX
brainmatters-1090	90	15	a	a	DET
brainmatters-1090	90	16	freshman	freshman	NOUN
brainmatters-1090	90	17	majoring	majoring	NOUN
brainmatters-1090	90	18	in	in	ADP
brainmatters-1090	90	19	neuroscience	neuroscience	NOUN
brainmatters-1090	90	20	with	with	ADP
brainmatters-1090	90	21	minors	minor	NOUN
brainmatters-1090	90	22	in	in	ADP
brainmatters-1090	90	23	linguistics	linguistic	NOUN
brainmatters-1090	90	24	and	and	CCONJ
brainmatters-1090	90	25	psychology	psychology	NOUN
brainmatters-1090	90	26	on	on	ADP
brainmatters-1090	90	27	the	the	DET
brainmatters-1090	90	28	pre	pre	ADJ
brainmatters-1090	90	29	-	-	ADJ
brainmatters-1090	90	30	med	med	ADJ
brainmatters-1090	90	31	track	track	NOUN
brainmatters-1090	90	32	.	.	PUNCT
brainmatters-1090	91	1	emily	emily	PROPN
brainmatters-1090	91	2	joined	join	VERB
brainmatters-1090	91	3	brain	brain	NOUN
brainmatters-1090	91	4	matters	matter	NOUN
brainmatters-1090	91	5	to	to	PART
brainmatters-1090	91	6	gain	gain	VERB
brainmatters-1090	91	7	a	a	DET
brainmatters-1090	91	8	deeper	deep	ADJ
brainmatters-1090	91	9	understanding	understanding	NOUN
brainmatters-1090	91	10	of	of	ADP
brainmatters-1090	91	11	the	the	DET
brainmatters-1090	91	12	brain	brain	NOUN
brainmatters-1090	91	13	through	through	ADP
brainmatters-1090	91	14	exploring	explore	VERB
brainmatters-1090	91	15	current	current	ADJ
brainmatters-1090	91	16	research	research	NOUN
brainmatters-1090	91	17	topics	topic	NOUN
brainmatters-1090	91	18	in	in	ADP
brainmatters-1090	91	19	neuroscience	neuroscience	NOUN
brainmatters-1090	91	20	.	.	PUNCT
brainmatters-1090	92	1	in	in	ADP
brainmatters-1090	92	2	her	her	PRON
brainmatters-1090	92	3	free	free	ADJ
brainmatters-1090	92	4	time	time	NOUN
brainmatters-1090	92	5	,	,	PUNCT
brainmatters-1090	92	6	she	she	PRON
brainmatters-1090	92	7	enjoys	enjoy	VERB
brainmatters-1090	92	8	listening	listen	VERB
brainmatters-1090	92	9	to	to	ADP
brainmatters-1090	92	10	music	music	NOUN
brainmatters-1090	92	11	,	,	PUNCT
brainmatters-1090	92	12	reading	reading	NOUN
brainmatters-1090	92	13	,	,	PUNCT
brainmatters-1090	92	14	and	and	CCONJ
brainmatters-1090	92	15	spending	spending	NOUN
brainmatters-1090	92	16	time	time	NOUN
brainmatters-1090	92	17	with	with	ADP
brainmatters-1090	92	18	friends	friend	NOUN
brainmatters-1090	92	19	.	.	PUNCT
brainmatters-1090	93	1	35	35	NUM