id	sid	tid	token	lemma	pos
brainmatters-818	1	1	copy	copy	NOUN
brainmatters-818	1	2	of	of	ADP
brainmatters-818	1	3	brain	brain	NOUN
brainmatters-818	1	4	matters	matter	NOUN
brainmatters-818	1	5	template	template	VERB
brainmatters-818	1	6	final	final	ADJ
brainmatters-818	1	7	introduction	introduction	NOUN
brainmatters-818	1	8	many	many	ADJ
brainmatters-818	1	9	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	1	10	diseases	disease	NOUN
brainmatters-818	1	11	:	:	PUNCT
brainmatters-818	1	12	alzheimer	alzheimer	PROPN
brainmatters-818	1	13	’s	’s	PART
brainmatters-818	1	14	disease	disease	NOUN
brainmatters-818	1	15	,	,	PUNCT
brainmatters-818	1	16	huntingtion	huntingtion	NOUN
brainmatters-818	1	17	’s	’s	PART
brainmatters-818	1	18	disease	disease	NOUN
brainmatters-818	1	19	,	,	PUNCT
brainmatters-818	1	20	duchenne	duchenne	PROPN
brainmatters-818	1	21	’s	’s	PART
brainmatters-818	1	22	muscular	muscular	ADJ
brainmatters-818	1	23	dystrophy	dystrophy	NOUN
brainmatters-818	1	24	,	,	PUNCT
brainmatters-818	1	25	and	and	CCONJ
brainmatters-818	1	26	spinal	spinal	ADJ
brainmatters-818	1	27	muscular	muscular	ADJ
brainmatters-818	1	28	atrophy	atrophy	NOUN
brainmatters-818	1	29	,	,	PUNCT
brainmatters-818	1	30	are	be	AUX
brainmatters-818	1	31	linked	link	VERB
brainmatters-818	1	32	to	to	ADP
brainmatters-818	1	33	the	the	DET
brainmatters-818	1	34	aggregation	aggregation	NOUN
brainmatters-818	1	35	of	of	ADP
brainmatters-818	1	36	toxic	toxic	ADJ
brainmatters-818	1	37	proteins	protein	NOUN
brainmatters-818	1	38	in	in	ADP
brainmatters-818	1	39	the	the	DET
brainmatters-818	1	40	nervous	nervous	ADJ
brainmatters-818	1	41	system	system	NOUN
brainmatters-818	1	42	.	.	PUNCT
brainmatters-818	2	1	although	although	SCONJ
brainmatters-818	2	2	significant	significant	ADJ
brainmatters-818	2	3	strides	stride	NOUN
brainmatters-818	2	4	have	have	AUX
brainmatters-818	2	5	been	be	AUX
brainmatters-818	2	6	made	make	VERB
brainmatters-818	2	7	in	in	ADP
brainmatters-818	2	8	studying	study	VERB
brainmatters-818	2	9	the	the	DET
brainmatters-818	2	10	mechanisms	mechanism	NOUN
brainmatters-818	2	11	of	of	ADP
brainmatters-818	2	12	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	2	13	diseases	disease	NOUN
brainmatters-818	2	14	,	,	PUNCT
brainmatters-818	2	15	the	the	DET
brainmatters-818	2	16	consequent	consequent	ADJ
brainmatters-818	2	17	advancements	advancement	NOUN
brainmatters-818	2	18	in	in	ADP
brainmatters-818	2	19	therapies	therapy	NOUN
brainmatters-818	2	20	for	for	ADP
brainmatters-818	2	21	treating	treat	VERB
brainmatters-818	2	22	them	they	PRON
brainmatters-818	2	23	have	have	AUX
brainmatters-818	2	24	been	be	AUX
brainmatters-818	2	25	slower	slow	ADJ
brainmatters-818	2	26	.	.	PUNCT
brainmatters-818	3	1	antisense	antisense	NOUN
brainmatters-818	3	2	oligonucleotide	oligonucleotide	NOUN
brainmatters-818	3	3	-	-	PUNCT
brainmatters-818	3	4	based	base	VERB
brainmatters-818	3	5	strategies	strategy	NOUN
brainmatters-818	3	6	(	(	PUNCT
brainmatters-818	3	7	asos	asos	NOUN
brainmatters-818	3	8	)	)	PUNCT
brainmatters-818	3	9	are	be	AUX
brainmatters-818	3	10	the	the	DET
brainmatters-818	3	11	most	most	ADV
brainmatters-818	3	12	direct	direct	ADJ
brainmatters-818	3	13	method	method	NOUN
brainmatters-818	3	14	of	of	ADP
brainmatters-818	3	15	targeting	target	VERB
brainmatters-818	3	16	gene	gene	NOUN
brainmatters-818	3	17	expression	expression	NOUN
brainmatters-818	3	18	.	.	PUNCT
brainmatters-818	4	1	aso	aso	NOUN
brainmatters-818	4	2	strategies	strategy	NOUN
brainmatters-818	4	3	utilize	utilize	VERB
brainmatters-818	4	4	synthetic	synthetic	ADJ
brainmatters-818	4	5	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	4	6	which	which	PRON
brainmatters-818	4	7	bind	bind	VERB
brainmatters-818	4	8	to	to	ADP
brainmatters-818	4	9	the	the	DET
brainmatters-818	4	10	target	target	NOUN
brainmatters-818	4	11	mrna	mrna	NOUN
brainmatters-818	4	12	by	by	ADP
brainmatters-818	4	13	watson	watson	PROPN
brainmatters-818	4	14	-	-	PUNCT
brainmatters-818	4	15	crick	crick	NOUN
brainmatters-818	4	16	hybridization	hybridization	NOUN
brainmatters-818	4	17	and	and	CCONJ
brainmatters-818	4	18	can	can	AUX
brainmatters-818	4	19	either	either	CCONJ
brainmatters-818	4	20	promote	promote	VERB
brainmatters-818	4	21	or	or	CCONJ
brainmatters-818	4	22	inhibit	inhibit	VERB
brainmatters-818	4	23	the	the	DET
brainmatters-818	4	24	degradation	degradation	NOUN
brainmatters-818	4	25	of	of	ADP
brainmatters-818	4	26	this	this	DET
brainmatters-818	4	27	rna	rna	NOUN
brainmatters-818	4	28	,	,	PUNCT
brainmatters-818	4	29	leading	lead	VERB
brainmatters-818	4	30	to	to	ADP
brainmatters-818	4	31	a	a	DET
brainmatters-818	4	32	knock	knock	NOUN
brainmatters-818	4	33	down	down	ADP
brainmatters-818	4	34	of	of	ADP
brainmatters-818	4	35	gene	gene	NOUN
brainmatters-818	4	36	expression	expression	NOUN
brainmatters-818	4	37	.	.	PUNCT
brainmatters-818	5	1	in	in	ADP
brainmatters-818	5	2	2016	2016	NUM
brainmatters-818	5	3	,	,	PUNCT
brainmatters-818	5	4	two	two	NUM
brainmatters-818	5	5	aso	aso	NOUN
brainmatters-818	5	6	therapies	therapy	NOUN
brainmatters-818	5	7	for	for	ADP
brainmatters-818	5	8	spinal	spinal	ADJ
brainmatters-818	5	9	muscular	muscular	ADJ
brainmatters-818	5	10	atrophy	atrophy	NOUN
brainmatters-818	5	11	and	and	CCONJ
brainmatters-818	5	12	duchenne	duchenne	VERB
brainmatters-818	5	13	muscular	muscular	ADJ
brainmatters-818	5	14	dystrophy	dystrophy	NOUN
brainmatters-818	5	15	were	be	AUX
brainmatters-818	5	16	approved	approve	VERB
brainmatters-818	5	17	by	by	ADP
brainmatters-818	5	18	the	the	DET
brainmatters-818	5	19	fda	fda	PROPN
brainmatters-818	5	20	.	.	PUNCT
brainmatters-818	6	1	this	this	PRON
brainmatters-818	6	2	marked	mark	VERB
brainmatters-818	6	3	a	a	DET
brainmatters-818	6	4	shift	shift	NOUN
brainmatters-818	6	5	in	in	ADP
brainmatters-818	6	6	the	the	DET
brainmatters-818	6	7	direction	direction	NOUN
brainmatters-818	6	8	of	of	ADP
brainmatters-818	6	9	treatment	treatment	NOUN
brainmatters-818	6	10	strategies	strategy	NOUN
brainmatters-818	6	11	towards	towards	ADP
brainmatters-818	6	12	antisense	antisense	NOUN
brainmatters-818	6	13	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	6	14	(	(	PUNCT
brainmatters-818	6	15	asos	asos	NOUN
brainmatters-818	6	16	)	)	PUNCT
brainmatters-818	6	17	.	.	PUNCT
brainmatters-818	7	1	asos	asos	PROPN
brainmatters-818	7	2	can	can	AUX
brainmatters-818	7	3	target	target	VERB
brainmatters-818	7	4	gene	gene	NOUN
brainmatters-818	7	5	expression	expression	NOUN
brainmatters-818	7	6	through	through	ADP
brainmatters-818	7	7	a	a	DET
brainmatters-818	7	8	variety	variety	NOUN
brainmatters-818	7	9	of	of	ADP
brainmatters-818	7	10	mechanisms	mechanism	NOUN
brainmatters-818	7	11	including	include	VERB
brainmatters-818	7	12	altering	alter	VERB
brainmatters-818	7	13	the	the	DET
brainmatters-818	7	14	splicing	splicing	NOUN
brainmatters-818	7	15	of	of	ADP
brainmatters-818	7	16	pre	pre	ADJ
brainmatters-818	7	17	-	-	ADJ
brainmatters-818	7	18	mrna	mrna	ADJ
brainmatters-818	7	19	,	,	PUNCT
brainmatters-818	7	20	blocking	block	VERB
brainmatters-818	7	21	mrna	mrna	NOUN
brainmatters-818	7	22	translation	translation	NOUN
brainmatters-818	7	23	or	or	CCONJ
brainmatters-818	7	24	preventing	prevent	VERB
brainmatters-818	7	25	the	the	DET
brainmatters-818	7	26	assembly	assembly	NOUN
brainmatters-818	7	27	of	of	ADP
brainmatters-818	7	28	ribosomal	ribosomal	NOUN
brainmatters-818	7	29	complexes	complex	NOUN
brainmatters-818	7	30	.	.	PUNCT
brainmatters-818	8	1	the	the	DET
brainmatters-818	8	2	main	main	ADJ
brainmatters-818	8	3	complication	complication	NOUN
brainmatters-818	8	4	in	in	ADP
brainmatters-818	8	5	aso	aso	NOUN
brainmatters-818	8	6	therapies	therapy	NOUN
brainmatters-818	8	7	is	be	AUX
brainmatters-818	8	8	that	that	SCONJ
brainmatters-818	8	9	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	8	10	can	can	AUX
brainmatters-818	8	11	not	not	PART
brainmatters-818	8	12	cross	cross	VERB
brainmatters-818	8	13	the	the	DET
brainmatters-818	8	14	blood	blood	NOUN
brainmatters-818	8	15	brain	brain	NOUN
brainmatters-818	8	16	barrier	barrier	NOUN
brainmatters-818	8	17	and	and	CCONJ
brainmatters-818	8	18	thus	thus	ADV
brainmatters-818	8	19	,	,	PUNCT
brainmatters-818	8	20	require	require	VERB
brainmatters-818	8	21	invasive	invasive	ADJ
brainmatters-818	8	22	forms	form	NOUN
brainmatters-818	8	23	of	of	ADP
brainmatters-818	8	24	delivery	delivery	NOUN
brainmatters-818	8	25	.	.	PUNCT
brainmatters-818	9	1	this	this	DET
brainmatters-818	9	2	article	article	NOUN
brainmatters-818	9	3	will	will	AUX
brainmatters-818	9	4	discuss	discuss	VERB
brainmatters-818	9	5	mechanisms	mechanism	NOUN
brainmatters-818	9	6	of	of	ADP
brainmatters-818	9	7	aso	aso	NOUN
brainmatters-818	9	8	-	-	PUNCT
brainmatters-818	9	9	therapy	therapy	NOUN
brainmatters-818	9	10	,	,	PUNCT
brainmatters-818	9	11	challenges	challenge	NOUN
brainmatters-818	9	12	in	in	ADP
brainmatters-818	9	13	its	its	PRON
brainmatters-818	9	14	clinical	clinical	ADJ
brainmatters-818	9	15	applications	application	NOUN
brainmatters-818	9	16	,	,	PUNCT
brainmatters-818	9	17	fda	fda	PROPN
brainmatters-818	9	18	-	-	PUNCT
brainmatters-818	9	19	approved	approve	VERB
brainmatters-818	9	20	aso	aso	NOUN
brainmatters-818	9	21	therapies	therapy	NOUN
brainmatters-818	9	22	,	,	PUNCT
brainmatters-818	9	23	and	and	CCONJ
brainmatters-818	9	24	future	future	ADJ
brainmatters-818	9	25	development	development	NOUN
brainmatters-818	9	26	.	.	PUNCT
brainmatters-818	10	1	mechanisms	mechanism	NOUN
brainmatters-818	10	2	of	of	ADP
brainmatters-818	10	3	aso	aso	NOUN
brainmatters-818	10	4	-	-	PUNCT
brainmatters-818	10	5	therapy	therapy	NOUN
brainmatters-818	10	6	many	many	ADJ
brainmatters-818	10	7	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	10	8	diseases	disease	NOUN
brainmatters-818	10	9	:	:	PUNCT
brainmatters-818	10	10	alzheimer	alzheimer	PROPN
brainmatters-818	10	11	’s	’s	PART
brainmatters-818	10	12	disease	disease	NOUN
brainmatters-818	10	13	,	,	PUNCT
brainmatters-818	10	14	huntingtion	huntingtion	NOUN
brainmatters-818	10	15	’s	’s	PART
brainmatters-818	10	16	disease	disease	NOUN
brainmatters-818	10	17	,	,	PUNCT
brainmatters-818	10	18	duchenne	duchenne	PROPN
brainmatters-818	10	19	’s	’s	PART
brainmatters-818	10	20	muscular	muscular	ADJ
brainmatters-818	10	21	dystrophy	dystrophy	NOUN
brainmatters-818	10	22	,	,	PUNCT
brainmatters-818	10	23	and	and	CCONJ
brainmatters-818	10	24	spinal	spinal	ADJ
brainmatters-818	10	25	muscular	muscular	ADJ
brainmatters-818	10	26	atrophy	atrophy	NOUN
brainmatters-818	10	27	,	,	PUNCT
brainmatters-818	10	28	are	be	AUX
brainmatters-818	10	29	linked	link	VERB
brainmatters-818	10	30	to	to	ADP
brainmatters-818	10	31	the	the	DET
brainmatters-818	10	32	aggregation	aggregation	NOUN
brainmatters-818	10	33	of	of	ADP
brainmatters-818	10	34	toxic	toxic	ADJ
brainmatters-818	10	35	proteins	protein	NOUN
brainmatters-818	10	36	in	in	ADP
brainmatters-818	10	37	the	the	DET
brainmatters-818	10	38	nervous	nervous	ADJ
brainmatters-818	10	39	system	system	NOUN
brainmatters-818	10	40	.	.	PUNCT
brainmatters-818	11	1	although	although	SCONJ
brainmatters-818	11	2	significant	significant	ADJ
brainmatters-818	11	3	strides	stride	NOUN
brainmatters-818	11	4	have	have	AUX
brainmatters-818	11	5	been	be	AUX
brainmatters-818	11	6	made	make	VERB
brainmatters-818	11	7	in	in	ADP
brainmatters-818	11	8	studying	study	VERB
brainmatters-818	11	9	the	the	DET
brainmatters-818	11	10	mechanisms	mechanism	NOUN
brainmatters-818	11	11	of	of	ADP
brainmatters-818	11	12	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	11	13	diseases	disease	NOUN
brainmatters-818	11	14	,	,	PUNCT
brainmatters-818	11	15	the	the	DET
brainmatters-818	11	16	consequent	consequent	ADJ
brainmatters-818	11	17	advancements	advancement	NOUN
brainmatters-818	11	18	in	in	ADP
brainmatters-818	11	19	therapies	therapy	NOUN
brainmatters-818	11	20	for	for	ADP
brainmatters-818	11	21	treating	treat	VERB
brainmatters-818	11	22	them	they	PRON
brainmatters-818	11	23	have	have	AUX
brainmatters-818	11	24	been	be	AUX
brainmatters-818	11	25	slower	slow	ADJ
brainmatters-818	11	26	.	.	PUNCT
brainmatters-818	12	1	antisense	antisense	NOUN
brainmatters-818	12	2	oligonucleotide	oligonucleotide	NOUN
brainmatters-818	12	3	-	-	PUNCT
brainmatters-818	12	4	based	base	VERB
brainmatters-818	12	5	strategies	strategy	NOUN
brainmatters-818	12	6	(	(	PUNCT
brainmatters-818	12	7	asos	asos	NOUN
brainmatters-818	12	8	)	)	PUNCT
brainmatters-818	12	9	are	be	AUX
brainmatters-818	12	10	the	the	DET
brainmatters-818	12	11	most	most	ADV
brainmatters-818	12	12	direct	direct	ADJ
brainmatters-818	12	13	method	method	NOUN
brainmatters-818	12	14	of	of	ADP
brainmatters-818	12	15	targeting	target	VERB
brainmatters-818	12	16	gene	gene	NOUN
brainmatters-818	12	17	expression	expression	NOUN
brainmatters-818	12	18	.	.	PUNCT
brainmatters-818	13	1	aso	aso	NOUN
brainmatters-818	13	2	strategies	strategy	NOUN
brainmatters-818	13	3	utilize	utilize	VERB
brainmatters-818	13	4	synthetic	synthetic	ADJ
brainmatters-818	13	5	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	13	6	which	which	PRON
brainmatters-818	13	7	bind	bind	VERB
brainmatters-818	13	8	to	to	ADP
brainmatters-818	13	9	the	the	DET
brainmatters-818	13	10	target	target	NOUN
brainmatters-818	13	11	mrna	mrna	NOUN
brainmatters-818	13	12	by	by	ADP
brainmatters-818	13	13	watson	watson	PROPN
brainmatters-818	13	14	-	-	PUNCT
brainmatters-818	13	15	crick	crick	NOUN
brainmatters-818	13	16	hybridization	hybridization	NOUN
brainmatters-818	13	17	and	and	CCONJ
brainmatters-818	13	18	can	can	AUX
brainmatters-818	13	19	either	either	CCONJ
brainmatters-818	13	20	promote	promote	VERB
brainmatters-818	13	21	or	or	CCONJ
brainmatters-818	13	22	inhibit	inhibit	VERB
brainmatters-818	13	23	the	the	DET
brainmatters-818	13	24	degradation	degradation	NOUN
brainmatters-818	13	25	of	of	ADP
brainmatters-818	13	26	this	this	DET
brainmatters-818	13	27	rna	rna	NOUN
brainmatters-818	13	28	,	,	PUNCT
brainmatters-818	13	29	leading	lead	VERB
brainmatters-818	13	30	to	to	ADP
brainmatters-818	13	31	a	a	DET
brainmatters-818	13	32	knock	knock	NOUN
brainmatters-818	13	33	down	down	ADP
brainmatters-818	13	34	of	of	ADP
brainmatters-818	13	35	gene	gene	NOUN
brainmatters-818	13	36	expression	expression	NOUN
brainmatters-818	13	37	.	.	PUNCT
brainmatters-818	14	1	in	in	ADP
brainmatters-818	14	2	2016	2016	NUM
brainmatters-818	14	3	,	,	PUNCT
brainmatters-818	14	4	two	two	NUM
brainmatters-818	14	5	aso	aso	NOUN
brainmatters-818	14	6	therapies	therapy	NOUN
brainmatters-818	14	7	for	for	ADP
brainmatters-818	14	8	spinal	spinal	ADJ
brainmatters-818	14	9	muscular	muscular	ADJ
brainmatters-818	14	10	atrophy	atrophy	NOUN
brainmatters-818	14	11	and	and	CCONJ
brainmatters-818	14	12	duchenne	duchenne	VERB
brainmatters-818	14	13	muscular	muscular	ADJ
brainmatters-818	14	14	dystrophy	dystrophy	NOUN
brainmatters-818	14	15	were	be	AUX
brainmatters-818	14	16	approved	approve	VERB
brainmatters-818	14	17	by	by	ADP
brainmatters-818	14	18	the	the	DET
brainmatters-818	14	19	fda	fda	PROPN
brainmatters-818	14	20	.	.	PUNCT
brainmatters-818	15	1	abstract	abstract	ADJ
brainmatters-818	15	2	many	many	ADJ
brainmatters-818	15	3	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	15	4	diseases	disease	NOUN
brainmatters-818	15	5	like	like	ADP
brainmatters-818	15	6	alzheimer	alzheimer	PROPN
brainmatters-818	15	7	’s	’s	PART
brainmatters-818	15	8	disease	disease	NOUN
brainmatters-818	15	9	,	,	PUNCT
brainmatters-818	15	10	huntingtion	huntingtion	NOUN
brainmatters-818	15	11	’s	’s	PART
brainmatters-818	15	12	disease	disease	NOUN
brainmatters-818	15	13	,	,	PUNCT
brainmatters-818	15	14	duchenne	duchenne	PROPN
brainmatters-818	15	15	’s	’s	PART
brainmatters-818	15	16	muscular	muscular	ADJ
brainmatters-818	15	17	dystrophy	dystrophy	NOUN
brainmatters-818	15	18	and	and	CCONJ
brainmatters-818	15	19	spinal	spinal	ADJ
brainmatters-818	15	20	muscular	muscular	ADJ
brainmatters-818	15	21	atrophy	atrophy	NOUN
brainmatters-818	15	22	are	be	AUX
brainmatters-818	15	23	linked	link	VERB
brainmatters-818	15	24	to	to	PART
brainmatters-818	15	25	aggregated	aggregate	VERB
brainmatters-818	15	26	,	,	PUNCT
brainmatters-818	15	27	toxic	toxic	ADJ
brainmatters-818	15	28	proteins	protein	NOUN
brainmatters-818	15	29	.	.	PUNCT
brainmatters-818	16	1	antisense	antisense	NOUN
brainmatters-818	16	2	oligonucleotide	oligonucleotide	NOUN
brainmatters-818	16	3	-	-	PUNCT
brainmatters-818	16	4	based	base	VERB
brainmatters-818	16	5	strategies	strategy	NOUN
brainmatters-818	16	6	(	(	PUNCT
brainmatters-818	16	7	asos	asos	NOUN
brainmatters-818	16	8	)	)	PUNCT
brainmatters-818	16	9	are	be	AUX
brainmatters-818	16	10	the	the	DET
brainmatters-818	16	11	most	most	ADV
brainmatters-818	16	12	direct	direct	ADJ
brainmatters-818	16	13	method	method	NOUN
brainmatters-818	16	14	of	of	ADP
brainmatters-818	16	15	targeting	target	VERB
brainmatters-818	16	16	gene	gene	NOUN
brainmatters-818	16	17	expression	expression	NOUN
brainmatters-818	16	18	.	.	PUNCT
brainmatters-818	17	1	synthetic	synthetic	ADJ
brainmatters-818	17	2	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	17	3	bind	bind	VERB
brainmatters-818	17	4	to	to	ADP
brainmatters-818	17	5	the	the	DET
brainmatters-818	17	6	target	target	NOUN
brainmatters-818	17	7	mrna	mrna	NOUN
brainmatters-818	17	8	by	by	ADP
brainmatters-818	17	9	watson	watson	PROPN
brainmatters-818	17	10	-	-	PUNCT
brainmatters-818	17	11	crick	crick	NOUN
brainmatters-818	17	12	hybridization	hybridization	NOUN
brainmatters-818	17	13	and	and	CCONJ
brainmatters-818	17	14	can	can	AUX
brainmatters-818	17	15	either	either	CCONJ
brainmatters-818	17	16	promote	promote	VERB
brainmatters-818	17	17	the	the	DET
brainmatters-818	17	18	degradation	degradation	NOUN
brainmatters-818	17	19	of	of	ADP
brainmatters-818	17	20	rna	rna	NOUN
brainmatters-818	17	21	or	or	CCONJ
brainmatters-818	17	22	inhibit	inhibit	VERB
brainmatters-818	17	23	it	it	PRON
brainmatters-818	17	24	.	.	PUNCT
brainmatters-818	18	1	in	in	ADP
brainmatters-818	18	2	2016	2016	NUM
brainmatters-818	18	3	,	,	PUNCT
brainmatters-818	18	4	two	two	NUM
brainmatters-818	18	5	aso	aso	NOUN
brainmatters-818	18	6	therapies	therapy	NOUN
brainmatters-818	18	7	for	for	ADP
brainmatters-818	18	8	spinal	spinal	ADJ
brainmatters-818	18	9	muscular	muscular	ADJ
brainmatters-818	18	10	atrophy	atrophy	NOUN
brainmatters-818	18	11	and	and	CCONJ
brainmatters-818	18	12	duchenne	duchenne	VERB
brainmatters-818	18	13	muscular	muscular	ADJ
brainmatters-818	18	14	dystrophy	dystrophy	NOUN
brainmatters-818	18	15	were	be	AUX
brainmatters-818	18	16	approved	approve	VERB
brainmatters-818	18	17	by	by	ADP
brainmatters-818	18	18	the	the	DET
brainmatters-818	18	19	fda	fda	PROPN
brainmatters-818	18	20	.	.	PUNCT
brainmatters-818	19	1	this	this	PRON
brainmatters-818	19	2	marked	mark	VERB
brainmatters-818	19	3	a	a	DET
brainmatters-818	19	4	shift	shift	NOUN
brainmatters-818	19	5	in	in	ADP
brainmatters-818	19	6	the	the	DET
brainmatters-818	19	7	direction	direction	NOUN
brainmatters-818	19	8	of	of	ADP
brainmatters-818	19	9	treatment	treatment	NOUN
brainmatters-818	19	10	strategies	strategy	NOUN
brainmatters-818	19	11	towards	towards	ADP
brainmatters-818	19	12	antisense	antisense	NOUN
brainmatters-818	19	13	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	19	14	(	(	PUNCT
brainmatters-818	19	15	asos	asos	NOUN
brainmatters-818	19	16	)	)	PUNCT
brainmatters-818	19	17	.	.	PUNCT
brainmatters-818	20	1	asos	asos	PROPN
brainmatters-818	20	2	can	can	AUX
brainmatters-818	20	3	target	target	VERB
brainmatters-818	20	4	gene	gene	NOUN
brainmatters-818	20	5	expression	expression	NOUN
brainmatters-818	20	6	through	through	ADP
brainmatters-818	20	7	a	a	DET
brainmatters-818	20	8	variety	variety	NOUN
brainmatters-818	20	9	of	of	ADP
brainmatters-818	20	10	mechanisms	mechanism	NOUN
brainmatters-818	20	11	including	include	VERB
brainmatters-818	20	12	altering	alter	VERB
brainmatters-818	20	13	the	the	DET
brainmatters-818	20	14	splicing	splicing	NOUN
brainmatters-818	20	15	of	of	ADP
brainmatters-818	20	16	pre	pre	ADJ
brainmatters-818	20	17	-	-	ADJ
brainmatters-818	20	18	mrna	mrna	ADJ
brainmatters-818	20	19	,	,	PUNCT
brainmatters-818	20	20	blocking	block	VERB
brainmatters-818	20	21	mrna	mrna	NOUN
brainmatters-818	20	22	translation	translation	NOUN
brainmatters-818	20	23	or	or	CCONJ
brainmatters-818	20	24	preventing	prevent	VERB
brainmatters-818	20	25	the	the	DET
brainmatters-818	20	26	assembly	assembly	NOUN
brainmatters-818	20	27	of	of	ADP
brainmatters-818	20	28	ribosomal	ribosomal	NOUN
brainmatters-818	20	29	complexes	complex	NOUN
brainmatters-818	20	30	.	.	PUNCT
brainmatters-818	21	1	while	while	SCONJ
brainmatters-818	21	2	maternal	maternal	ADJ
brainmatters-818	21	3	stress	stress	NOUN
brainmatters-818	21	4	can	can	AUX
brainmatters-818	21	5	negatively	negatively	ADV
brainmatters-818	21	6	impact	impact	VERB
brainmatters-818	21	7	the	the	DET
brainmatters-818	21	8	developing	develop	VERB
brainmatters-818	21	9	fetus	fetus	NOUN
brainmatters-818	21	10	in	in	ADP
brainmatters-818	21	11	a	a	DET
brainmatters-818	21	12	plethora	plethora	NOUN
brainmatters-818	21	13	of	of	ADP
brainmatters-818	21	14	ways	way	NOUN
brainmatters-818	21	15	,	,	PUNCT
brainmatters-818	21	16	stress	stress	NOUN
brainmatters-818	21	17	experienced	experience	VERB
brainmatters-818	21	18	in	in	ADP
brainmatters-818	21	19	childhood	childhood	NOUN
brainmatters-818	21	20	,	,	PUNCT
brainmatters-818	21	21	whether	whether	SCONJ
brainmatters-818	21	22	due	due	ADJ
brainmatters-818	21	23	to	to	ADP
brainmatters-818	21	24	severe	severe	ADJ
brainmatters-818	21	25	traumatic	traumatic	ADJ
brainmatters-818	21	26	events	event	NOUN
brainmatters-818	21	27	or	or	CCONJ
brainmatters-818	21	28	socioeconomic	socioeconomic	ADJ
brainmatters-818	21	29	standing	standing	NOUN
brainmatters-818	21	30	,	,	PUNCT
brainmatters-818	21	31	can	can	AUX
brainmatters-818	21	32	also	also	ADV
brainmatters-818	21	33	be	be	AUX
brainmatters-818	21	34	detrimental	detrimental	ADJ
brainmatters-818	21	35	to	to	ADP
brainmatters-818	21	36	development	development	NOUN
brainmatters-818	21	37	.	.	PUNCT
brainmatters-818	22	1	the	the	DET
brainmatters-818	22	2	amygdala	amygdala	NOUN
brainmatters-818	22	3	,	,	PUNCT
brainmatters-818	22	4	in	in	ADP
brainmatters-818	22	5	particular	particular	ADJ
brainmatters-818	22	6	,	,	PUNCT
brainmatters-818	22	7	is	be	AUX
brainmatters-818	22	8	highly	highly	ADV
brainmatters-818	22	9	susceptible	susceptible	ADJ
brainmatters-818	22	10	to	to	ADP
brainmatters-818	22	11	sensitivity	sensitivity	NOUN
brainmatters-818	22	12	due	due	ADJ
brainmatters-818	22	13	to	to	ADP
brainmatters-818	22	14	early	early	ADJ
brainmatters-818	22	15	life	life	NOUN
brainmatters-818	22	16	stressors	stressor	VERB
brainmatters-818	22	17	that	that	SCONJ
brainmatters-818	22	18	these	these	DET
brainmatters-818	22	19	children	child	NOUN
brainmatters-818	22	20	experience	experience	VERB
brainmatters-818	22	21	.	.	PUNCT
brainmatters-818	23	1	furthermore	furthermore	ADV
brainmatters-818	23	2	,	,	PUNCT
brainmatters-818	23	3	children	child	NOUN
brainmatters-818	23	4	who	who	PRON
brainmatters-818	23	5	experience	experience	VERB
brainmatters-818	23	6	early	early	ADJ
brainmatters-818	23	7	life	life	NOUN
brainmatters-818	23	8	stressors	stressor	NOUN
brainmatters-818	23	9	show	show	VERB
brainmatters-818	23	10	significant	significant	ADJ
brainmatters-818	23	11	deficits	deficit	NOUN
brainmatters-818	23	12	in	in	ADP
brainmatters-818	23	13	the	the	DET
brainmatters-818	23	14	affective	affective	ADJ
brainmatters-818	23	15	domain	domain	NOUN
brainmatters-818	23	16	and	and	CCONJ
brainmatters-818	23	17	in	in	ADP
brainmatters-818	23	18	brain	brain	NOUN
brainmatters-818	23	19	regions	region	NOUN
brainmatters-818	23	20	with	with	ADP
brainmatters-818	23	21	extended	extended	ADJ
brainmatters-818	23	22	postnatal	postnatal	ADJ
brainmatters-818	23	23	development	development	NOUN
brainmatters-818	23	24	such	such	ADJ
brainmatters-818	23	25	as	as	ADP
brainmatters-818	23	26	the	the	DET
brainmatters-818	23	27	hippocampus	hippocampus	NOUN
brainmatters-818	23	28	,	,	PUNCT
brainmatters-818	23	29	amygdala	amygdala	NOUN
brainmatters-818	23	30	,	,	PUNCT
brainmatters-818	23	31	and	and	CCONJ
brainmatters-818	23	32	prefrontal	prefrontal	ADJ
brainmatters-818	23	33	cortex	cortex	NOUN
brainmatters-818	23	34	(	(	PUNCT
brainmatters-818	23	35	pechtel	pechtel	NOUN
brainmatters-818	23	36	et	et	PROPN
brainmatters-818	23	37	al	al	PROPN
brainmatters-818	23	38	.	.	PROPN
brainmatters-818	23	39	2010	2010	NUM
brainmatters-818	23	40	)	)	PUNCT
brainmatters-818	23	41	.	.	PUNCT
brainmatters-818	24	1	early	early	ADJ
brainmatters-818	24	2	life	life	NOUN
brainmatters-818	24	3	stressors	stressor	NOUN
brainmatters-818	24	4	seem	seem	VERB
brainmatters-818	24	5	to	to	PART
brainmatters-818	24	6	interfere	interfere	VERB
brainmatters-818	24	7	with	with	ADP
brainmatters-818	24	8	the	the	DET
brainmatters-818	24	9	neurogenesis	neurogenesis	NOUN
brainmatters-818	24	10	,	,	PUNCT
brainmatters-818	24	11	synaptic	synaptic	ADJ
brainmatters-818	24	12	overproduction	overproduction	NOUN
brainmatters-818	24	13	,	,	PUNCT
brainmatters-818	24	14	and	and	CCONJ
brainmatters-818	24	15	pruning	prune	VERB
brainmatters-818	24	16	of	of	ADP
brainmatters-818	24	17	synapses	synapsis	NOUN
brainmatters-818	24	18	/	/	SYM
brainmatters-818	24	19	receptors	receptor	NOUN
brainmatters-818	24	20	,	,	PUNCT
brainmatters-818	24	21	thus	thus	ADV
brainmatters-818	24	22	impairing	impair	VERB
brainmatters-818	24	23	neural	neural	ADJ
brainmatters-818	24	24	plasticity	plasticity	NOUN
brainmatters-818	24	25	and	and	CCONJ
brainmatters-818	24	26	growth	growth	NOUN
brainmatters-818	24	27	in	in	ADP
brainmatters-818	24	28	the	the	DET
brainmatters-818	24	29	critical	critical	ADJ
brainmatters-818	24	30	brain	brain	NOUN
brainmatters-818	24	31	areas	area	NOUN
brainmatters-818	24	32	listed	list	VERB
brainmatters-818	24	33	above	above	ADV
brainmatters-818	24	34	(	(	PUNCT
brainmatters-818	24	35	pechtel	pechtel	NOUN
brainmatters-818	24	36	et	et	PROPN
brainmatters-818	24	37	al	al	PROPN
brainmatters-818	24	38	.	.	PROPN
brainmatters-818	24	39	2010	2010	NUM
brainmatters-818	24	40	)	)	PUNCT
brainmatters-818	24	41	.	.	PUNCT
brainmatters-818	25	1	the	the	DET
brainmatters-818	25	2	corpus	corpus	NOUN
brainmatters-818	25	3	callosum	callosum	NOUN
brainmatters-818	25	4	,	,	PUNCT
brainmatters-818	25	5	which	which	PRON
brainmatters-818	25	6	connects	connect	VERB
brainmatters-818	25	7	various	various	ADJ
brainmatters-818	25	8	aspects	aspect	NOUN
brainmatters-818	25	9	of	of	ADP
brainmatters-818	25	10	cognitive	cognitive	NOUN
brainmatters-818	25	11	,	,	PUNCT
brainmatters-818	25	12	motor	motor	NOUN
brainmatters-818	25	13	,	,	PUNCT
brainmatters-818	25	14	and	and	CCONJ
brainmatters-818	25	15	sensory	sensory	ADJ
brainmatters-818	25	16	functioning	functioning	NOUN
brainmatters-818	25	17	at	at	ADP
brainmatters-818	25	18	different	different	ADJ
brainmatters-818	25	19	stages	stage	NOUN
brainmatters-818	25	20	across	across	ADP
brainmatters-818	25	21	development	development	NOUN
brainmatters-818	25	22	,	,	PUNCT
brainmatters-818	25	23	decreases	decrease	VERB
brainmatters-818	25	24	in	in	ADP
brainmatters-818	25	25	size	size	NOUN
brainmatters-818	25	26	due	due	ADP
brainmatters-818	25	27	to	to	ADP
brainmatters-818	25	28	early	early	ADJ
brainmatters-818	25	29	due	due	ADJ
brainmatters-818	25	30	to	to	ADP
brainmatters-818	25	31	early	early	ADJ
brainmatters-818	25	32	life	life	NOUN
brainmatters-818	25	33	stressors	stressor	NOUN
brainmatters-818	25	34	.	.	PUNCT
brainmatters-818	26	1	in	in	ADP
brainmatters-818	26	2	addition	addition	NOUN
brainmatters-818	26	3	to	to	ADP
brainmatters-818	26	4	recruiting	recruit	VERB
brainmatters-818	26	5	cellular	cellular	ADJ
brainmatters-818	26	6	enzymes	enzyme	NOUN
brainmatters-818	26	7	,	,	PUNCT
brainmatters-818	26	8	asos	asos	PROPN
brainmatters-818	26	9	can	can	AUX
brainmatters-818	26	10	also	also	ADV
brainmatters-818	26	11	directly	directly	ADV
brainmatters-818	26	12	cleave	cleave	VERB
brainmatters-818	26	13	target	target	NOUN
brainmatters-818	26	14	rna	rna	NOUN
brainmatters-818	26	15	if	if	SCONJ
brainmatters-818	26	16	they	they	PRON
brainmatters-818	26	17	are	be	AUX
brainmatters-818	26	18	designed	design	VERB
brainmatters-818	26	19	with	with	ADP
brainmatters-818	26	20	their	their	PRON
brainmatters-818	26	21	own	own	ADJ
brainmatters-818	26	22	enzymatic	enzymatic	ADJ
brainmatters-818	26	23	activity	activity	NOUN
brainmatters-818	26	24	.	.	PUNCT
brainmatters-818	27	1	this	this	PRON
brainmatters-818	27	2	is	be	AUX
brainmatters-818	27	3	usually	usually	ADV
brainmatters-818	27	4	done	do	VERB
brainmatters-818	27	5	by	by	ADP
brainmatters-818	27	6	associating	associate	VERB
brainmatters-818	27	7	dnazymes	dnazyme	NOUN
brainmatters-818	27	8	and	and	CCONJ
brainmatters-818	27	9	ribozymes	ribozyme	NOUN
brainmatters-818	27	10	with	with	ADP
brainmatters-818	27	11	asos	asos	PROPN
brainmatters-818	27	12	.	.	PUNCT
brainmatters-818	28	1	asos	asos	PROPN
brainmatters-818	28	2	can	can	AUX
brainmatters-818	28	3	also	also	ADV
brainmatters-818	28	4	modify	modify	VERB
brainmatters-818	28	5	rnas	rna	NOUN
brainmatters-818	28	6	to	to	PART
brainmatters-818	28	7	alter	alter	VERB
brainmatters-818	28	8	their	their	PRON
brainmatters-818	28	9	stability	stability	NOUN
brainmatters-818	28	10	and	and	CCONJ
brainmatters-818	28	11	promote	promote	VERB
brainmatters-818	28	12	or	or	CCONJ
brainmatters-818	28	13	inhibit	inhibit	VERB
brainmatters-818	28	14	degradation	degradation	NOUN
brainmatters-818	28	15	.	.	PUNCT
brainmatters-818	29	1	asos	asos	PROPN
brainmatters-818	29	2	also	also	ADV
brainmatters-818	29	3	participate	participate	VERB
brainmatters-818	29	4	in	in	ADP
brainmatters-818	29	5	direct	direct	ADJ
brainmatters-818	29	6	translation	translation	NOUN
brainmatters-818	29	7	inhibition	inhibition	NOUN
brainmatters-818	29	8	by	by	ADP
brainmatters-818	29	9	sterically	sterically	ADV
brainmatters-818	29	10	blocking	block	VERB
brainmatters-818	29	11	ribosomes	ribosome	NOUN
brainmatters-818	29	12	.	.	PUNCT
brainmatters-818	30	1	this	this	DET
brainmatters-818	30	2	steric	steric	ADJ
brainmatters-818	30	3	block	block	NOUN
brainmatters-818	30	4	is	be	AUX
brainmatters-818	30	5	formed	form	VERB
brainmatters-818	30	6	when	when	SCONJ
brainmatters-818	30	7	asos	asos	PROPN
brainmatters-818	30	8	bind	bind	VERB
brainmatters-818	30	9	to	to	ADP
brainmatters-818	30	10	mrna	mrna	NOUN
brainmatters-818	30	11	and	and	CCONJ
brainmatters-818	30	12	prevent	prevent	VERB
brainmatters-818	30	13	the	the	DET
brainmatters-818	30	14	association	association	NOUN
brainmatters-818	30	15	of	of	ADP
brainmatters-818	30	16	the	the	DET
brainmatters-818	30	17	40s	40	NOUN
brainmatters-818	30	18	and	and	CCONJ
brainmatters-818	30	19	60s	60	NOUN
brainmatters-818	30	20	ribosomal	ribosomal	NOUN
brainmatters-818	30	21	subunits	subunit	NOUN
brainmatters-818	30	22	during	during	ADP
brainmatters-818	30	23	translation	translation	NOUN
brainmatters-818	30	24	.	.	PUNCT
brainmatters-818	31	1	furthermore	furthermore	ADV
brainmatters-818	31	2	,	,	PUNCT
brainmatters-818	31	3	asos	asos	PROPN
brainmatters-818	31	4	can	can	AUX
brainmatters-818	31	5	modulate	modulate	VERB
brainmatters-818	31	6	the	the	DET
brainmatters-818	31	7	splicing	splicing	NOUN
brainmatters-818	31	8	of	of	ADP
brainmatters-818	31	9	rna	rna	PROPN
brainmatters-818	31	10	into	into	ADP
brainmatters-818	31	11	mature	mature	ADJ
brainmatters-818	31	12	mrna	mrna	PROPN
brainmatters-818	31	13	transcripts	transcript	NOUN
brainmatters-818	31	14	.	.	PUNCT
brainmatters-818	32	1	asos	asos	PROPN
brainmatters-818	32	2	destabilize	destabilize	VERB
brainmatters-818	32	3	splice	splice	NOUN
brainmatters-818	32	4	sites	site	NOUN
brainmatters-818	32	5	by	by	ADP
brainmatters-818	32	6	binding	bind	VERB
brainmatters-818	32	7	to	to	ADP
brainmatters-818	32	8	intron	intron	ADJ
brainmatters-818	32	9	-	-	PUNCT
brainmatters-818	32	10	exon	exon	ADJ
brainmatters-818	32	11	junctions	junction	NOUN
brainmatters-818	32	12	thereby	thereby	ADV
brainmatters-818	32	13	preventing	prevent	VERB
brainmatters-818	32	14	the	the	DET
brainmatters-818	32	15	binding	binding	NOUN
brainmatters-818	32	16	of	of	ADP
brainmatters-818	32	17	splice	splice	NOUN
brainmatters-818	32	18	factors	factor	NOUN
brainmatters-818	32	19	.	.	PUNCT
brainmatters-818	33	1	if	if	SCONJ
brainmatters-818	33	2	the	the	DET
brainmatters-818	33	3	disorder	disorder	NOUN
brainmatters-818	33	4	is	be	AUX
brainmatters-818	33	5	known	know	VERB
brainmatters-818	33	6	to	to	PART
brainmatters-818	33	7	be	be	AUX
brainmatters-818	33	8	caused	cause	VERB
brainmatters-818	33	9	by	by	ADP
brainmatters-818	33	10	a	a	DET
brainmatters-818	33	11	splicing	splicing	NOUN
brainmatters-818	33	12	defect	defect	NOUN
brainmatters-818	33	13	,	,	PUNCT
brainmatters-818	33	14	it	it	PRON
brainmatters-818	33	15	is	be	AUX
brainmatters-818	33	16	suggested	suggest	VERB
brainmatters-818	33	17	that	that	SCONJ
brainmatters-818	33	18	asos	asos	NOUN
brainmatters-818	33	19	with	with	ADP
brainmatters-818	33	20	this	this	DET
brainmatters-818	33	21	mechanism	mechanism	NOUN
brainmatters-818	33	22	of	of	ADP
brainmatters-818	33	23	action	action	NOUN
brainmatters-818	33	24	are	be	AUX
brainmatters-818	33	25	used	use	VERB
brainmatters-818	33	26	to	to	PART
brainmatters-818	33	27	return	return	VERB
brainmatters-818	33	28	to	to	ADP
brainmatters-818	33	29	normal	normal	ADJ
brainmatters-818	33	30	function	function	NOUN
brainmatters-818	33	31	.	.	PUNCT
brainmatters-818	34	1	usage	usage	NOUN
brainmatters-818	34	2	of	of	ADP
brainmatters-818	34	3	asos	asos	NOUN
brainmatters-818	34	4	in	in	ADP
brainmatters-818	34	5	this	this	DET
brainmatters-818	34	6	case	case	NOUN
brainmatters-818	34	7	can	can	AUX
brainmatters-818	34	8	either	either	CCONJ
brainmatters-818	34	9	promote	promote	VERB
brainmatters-818	34	10	a	a	DET
brainmatters-818	34	11	return	return	NOUN
brainmatters-818	34	12	to	to	ADP
brainmatters-818	34	13	the	the	DET
brainmatters-818	34	14	original	original	ADJ
brainmatters-818	34	15	reading	reading	NOUN
brainmatters-818	34	16	frame	frame	NOUN
brainmatters-818	34	17	or	or	CCONJ
brainmatters-818	34	18	can	can	AUX
brainmatters-818	34	19	simply	simply	ADV
brainmatters-818	34	20	exclude	exclude	VERB
brainmatters-818	34	21	the	the	DET
brainmatters-818	34	22	mutated	mutate	VERB
brainmatters-818	34	23	dna	dna	NOUN
brainmatters-818	34	24	segment	segment	NOUN
brainmatters-818	34	25	of	of	ADP
brainmatters-818	34	26	the	the	DET
brainmatters-818	34	27	gene	gene	NOUN
brainmatters-818	34	28	.	.	PUNCT
brainmatters-818	35	1	current	current	ADJ
brainmatters-818	35	2	aso	aso	NOUN
brainmatters-818	35	3	therapies	therapy	NOUN
brainmatters-818	35	4	as	as	ADP
brainmatters-818	35	5	of	of	ADP
brainmatters-818	35	6	2019	2019	NUM
brainmatters-818	36	1	,	,	PUNCT
brainmatters-818	36	2	the	the	DET
brainmatters-818	36	3	fda	fda	PROPN
brainmatters-818	36	4	has	have	AUX
brainmatters-818	36	5	approved	approve	VERB
brainmatters-818	36	6	only	only	ADV
brainmatters-818	36	7	3	3	NUM
brainmatters-818	36	8	aso	aso	ADV
brainmatters-818	36	9	-	-	PUNCT
brainmatters-818	36	10	mediated	mediate	VERB
brainmatters-818	36	11	therapies	therapy	NOUN
brainmatters-818	36	12	for	for	ADP
brainmatters-818	36	13	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	36	14	diseases	disease	NOUN
brainmatters-818	36	15	:	:	PUNCT
brainmatters-818	36	16	antisense	antisense	NOUN
brainmatters-818	36	17	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	36	18	mediated	mediate	VERB
brainmatters-818	36	19	therapy	therapy	NOUN
brainmatters-818	36	20	for	for	ADP
brainmatters-818	36	21	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	36	22	disease	disease	NOUN
brainmatters-818	36	23	apurva	apurva	PROPN
brainmatters-818	36	24	nayak	nayak	PROPN
brainmatters-818	36	25	11	11	NUM
brainmatters-818	36	26	modifications	modification	NOUN
brainmatters-818	36	27	from	from	ADP
brainmatters-818	36	28	2	2	NUM
brainmatters-818	36	29	’	'	PUNCT
brainmatters-818	36	30	to	to	ADP
brainmatters-818	36	31	4	4	NUM
brainmatters-818	36	32	’	'	PUNCT
brainmatters-818	36	33	positions	position	NOUN
brainmatters-818	36	34	constrain	constrain	VERB
brainmatters-818	36	35	the	the	DET
brainmatters-818	36	36	sugar	sugar	NOUN
brainmatters-818	36	37	and	and	CCONJ
brainmatters-818	36	38	result	result	NOUN
brainmatters-818	36	39	in	in	ADP
brainmatters-818	36	40	stronger	strong	ADJ
brainmatters-818	36	41	binding	binding	NOUN
brainmatters-818	36	42	as	as	ADV
brainmatters-818	36	43	well	well	ADV
brainmatters-818	36	44	.	.	PUNCT
brainmatters-818	37	1	it	it	PRON
brainmatters-818	37	2	is	be	AUX
brainmatters-818	37	3	also	also	ADV
brainmatters-818	37	4	important	important	ADJ
brainmatters-818	37	5	that	that	SCONJ
brainmatters-818	37	6	long	long	ADJ
brainmatters-818	37	7	-	-	PUNCT
brainmatters-818	37	8	term	term	NOUN
brainmatters-818	37	9	and	and	CCONJ
brainmatters-818	37	10	side	side	NOUN
brainmatters-818	37	11	effects	effect	NOUN
brainmatters-818	37	12	are	be	AUX
brainmatters-818	37	13	studied	study	VERB
brainmatters-818	37	14	before	before	SCONJ
brainmatters-818	37	15	the	the	DET
brainmatters-818	37	16	therapies	therapy	NOUN
brainmatters-818	37	17	are	be	AUX
brainmatters-818	37	18	implemented	implement	VERB
brainmatters-818	37	19	.	.	PUNCT
brainmatters-818	38	1	there	there	PRON
brainmatters-818	38	2	are	be	VERB
brainmatters-818	38	3	two	two	NUM
brainmatters-818	38	4	possible	possible	ADJ
brainmatters-818	38	5	reasons	reason	NOUN
brainmatters-818	38	6	for	for	ADP
brainmatters-818	38	7	off	off	ADP
brainmatters-818	38	8	-	-	PUNCT
brainmatters-818	38	9	target	target	NOUN
brainmatters-818	38	10	effects	effect	NOUN
brainmatters-818	38	11	,	,	PUNCT
brainmatters-818	38	12	hybridization	hybridization	NOUN
brainmatters-818	38	13	dependent	dependent	ADJ
brainmatters-818	38	14	or	or	CCONJ
brainmatters-818	38	15	independent	independent	ADJ
brainmatters-818	38	16	.	.	PUNCT
brainmatters-818	39	1	as	as	SCONJ
brainmatters-818	39	2	asos	asos	PROPN
brainmatters-818	39	3	are	be	AUX
brainmatters-818	39	4	streamlined	streamline	VERB
brainmatters-818	39	5	to	to	PART
brainmatters-818	39	6	be	be	AUX
brainmatters-818	39	7	more	more	ADV
brainmatters-818	39	8	efficient	efficient	ADJ
brainmatters-818	39	9	and	and	CCONJ
brainmatters-818	39	10	their	their	PRON
brainmatters-818	39	11	effects	effect	NOUN
brainmatters-818	39	12	become	become	VERB
brainmatters-818	39	13	more	more	ADV
brainmatters-818	39	14	widespread	widespread	ADJ
brainmatters-818	39	15	,	,	PUNCT
brainmatters-818	39	16	the	the	DET
brainmatters-818	39	17	off	off	ADP
brainmatters-818	39	18	-	-	PUNCT
brainmatters-818	39	19	target	target	NOUN
brainmatters-818	39	20	effects	effect	NOUN
brainmatters-818	39	21	are	be	AUX
brainmatters-818	39	22	likely	likely	ADJ
brainmatters-818	39	23	to	to	PART
brainmatters-818	39	24	pose	pose	VERB
brainmatters-818	39	25	a	a	DET
brainmatters-818	39	26	larger	large	ADJ
brainmatters-818	39	27	problem	problem	NOUN
brainmatters-818	39	28	.	.	PUNCT
brainmatters-818	40	1	for	for	ADP
brainmatters-818	40	2	example	example	NOUN
brainmatters-818	40	3	,	,	PUNCT
brainmatters-818	40	4	as	as	SCONJ
brainmatters-818	40	5	aso	aso	PROPN
brainmatters-818	40	6	sequences	sequence	NOUN
brainmatters-818	40	7	get	get	VERB
brainmatters-818	40	8	shorter	short	ADJ
brainmatters-818	40	9	,	,	PUNCT
brainmatters-818	40	10	the	the	DET
brainmatters-818	40	11	risk	risk	NOUN
brainmatters-818	40	12	of	of	ADP
brainmatters-818	40	13	mismatched	mismatched	ADJ
brainmatters-818	40	14	complementary	complementary	ADJ
brainmatters-818	40	15	binding	bind	VERB
brainmatters-818	40	16	rises	rise	NOUN
brainmatters-818	40	17	and	and	CCONJ
brainmatters-818	40	18	this	this	PRON
brainmatters-818	40	19	leads	lead	VERB
brainmatters-818	40	20	to	to	ADP
brainmatters-818	40	21	a	a	DET
brainmatters-818	40	22	larger	large	ADJ
brainmatters-818	40	23	risk	risk	NOUN
brainmatters-818	40	24	of	of	ADP
brainmatters-818	40	25	influencing	influence	VERB
brainmatters-818	40	26	the	the	DET
brainmatters-818	40	27	expression	expression	NOUN
brainmatters-818	40	28	of	of	ADP
brainmatters-818	40	29	non	non	ADJ
brainmatters-818	40	30	-	-	ADJ
brainmatters-818	40	31	target	target	ADJ
brainmatters-818	40	32	rnas	rna	NOUN
brainmatters-818	40	33	.	.	PUNCT
brainmatters-818	41	1	future	future	ADJ
brainmatters-818	41	2	development	development	NOUN
brainmatters-818	41	3	as	as	ADP
brainmatters-818	41	4	a	a	DET
brainmatters-818	41	5	new	new	ADJ
brainmatters-818	41	6	type	type	NOUN
brainmatters-818	41	7	of	of	ADP
brainmatters-818	41	8	therapy	therapy	NOUN
brainmatters-818	41	9	,	,	PUNCT
brainmatters-818	41	10	asos	asos	PROPN
brainmatters-818	41	11	can	can	AUX
brainmatters-818	41	12	still	still	ADV
brainmatters-818	41	13	be	be	AUX
brainmatters-818	41	14	refined	refine	VERB
brainmatters-818	41	15	and	and	CCONJ
brainmatters-818	41	16	applied	apply	VERB
brainmatters-818	41	17	to	to	ADP
brainmatters-818	41	18	a	a	DET
brainmatters-818	41	19	broad	broad	ADJ
brainmatters-818	41	20	variety	variety	NOUN
brainmatters-818	41	21	of	of	ADP
brainmatters-818	41	22	diseases	disease	NOUN
brainmatters-818	41	23	outside	outside	ADP
brainmatters-818	41	24	of	of	ADP
brainmatters-818	41	25	the	the	DET
brainmatters-818	41	26	few	few	ADJ
brainmatters-818	41	27	known	know	VERB
brainmatters-818	41	28	so	so	ADV
brainmatters-818	41	29	far	far	ADV
brainmatters-818	41	30	.	.	PUNCT
brainmatters-818	42	1	for	for	ADP
brainmatters-818	42	2	example	example	NOUN
brainmatters-818	42	3	,	,	PUNCT
brainmatters-818	42	4	asos	asos	PROPN
brainmatters-818	42	5	mediated	mediate	VERB
brainmatters-818	42	6	by	by	ADP
brainmatters-818	42	7	rnase	rnase	PROPN
brainmatters-818	42	8	h	h	PROPN
brainmatters-818	42	9	are	be	AUX
brainmatters-818	42	10	the	the	DET
brainmatters-818	42	11	most	most	ADV
brainmatters-818	42	12	common	common	ADJ
brainmatters-818	42	13	mechanism	mechanism	NOUN
brainmatters-818	42	14	of	of	ADP
brainmatters-818	42	15	aso	aso	NOUN
brainmatters-818	42	16	therapies	therapy	NOUN
brainmatters-818	42	17	.	.	PUNCT
brainmatters-818	43	1	however	however	ADV
brainmatters-818	43	2	,	,	PUNCT
brainmatters-818	43	3	target	target	NOUN
brainmatters-818	43	4	rna	rna	NOUN
brainmatters-818	43	5	suppression	suppression	NOUN
brainmatters-818	43	6	can	can	AUX
brainmatters-818	43	7	also	also	ADV
brainmatters-818	43	8	be	be	AUX
brainmatters-818	43	9	achieved	achieve	VERB
brainmatters-818	43	10	by	by	ADP
brainmatters-818	43	11	other	other	ADJ
brainmatters-818	43	12	mechanisms	mechanism	NOUN
brainmatters-818	43	13	.	.	PUNCT
brainmatters-818	44	1	the	the	DET
brainmatters-818	44	2	modulation	modulation	NOUN
brainmatters-818	44	3	of	of	ADP
brainmatters-818	44	4	splicing	splicing	NOUN
brainmatters-818	44	5	is	be	AUX
brainmatters-818	44	6	very	very	ADV
brainmatters-818	44	7	promising	promising	ADJ
brainmatters-818	44	8	as	as	ADP
brainmatters-818	44	9	an	an	DET
brainmatters-818	44	10	alternative	alternative	ADJ
brainmatters-818	44	11	aso	aso	NOUN
brainmatters-818	44	12	mechanism	mechanism	NOUN
brainmatters-818	44	13	.	.	PUNCT
brainmatters-818	45	1	in	in	ADP
brainmatters-818	45	2	this	this	DET
brainmatters-818	45	3	case	case	NOUN
brainmatters-818	45	4	,	,	PUNCT
brainmatters-818	45	5	attuning	attune	VERB
brainmatters-818	45	6	splicing	splicing	NOUN
brainmatters-818	45	7	can	can	AUX
brainmatters-818	45	8	result	result	VERB
brainmatters-818	45	9	in	in	ADP
brainmatters-818	45	10	an	an	DET
brainmatters-818	45	11	out	out	ADJ
brainmatters-818	45	12	-	-	PUNCT
brainmatters-818	45	13	of	of	ADP
brainmatters-818	45	14	-	-	PUNCT
brainmatters-818	45	15	frame	frame	NOUN
brainmatters-818	45	16	deletion	deletion	NOUN
brainmatters-818	45	17	that	that	PRON
brainmatters-818	45	18	consequently	consequently	ADV
brainmatters-818	45	19	causes	cause	VERB
brainmatters-818	45	20	nonsense	nonsense	NOUN
brainmatters-818	45	21	decay	decay	NOUN
brainmatters-818	45	22	of	of	ADP
brainmatters-818	45	23	the	the	DET
brainmatters-818	45	24	transcript	transcript	NOUN
brainmatters-818	45	25	which	which	PRON
brainmatters-818	45	26	overall	overall	ADJ
brainmatters-818	45	27	,	,	PUNCT
brainmatters-818	45	28	results	result	NOUN
brainmatters-818	45	29	in	in	ADP
brainmatters-818	45	30	protein	protein	NOUN
brainmatters-818	45	31	knockdown	knockdown	NOUN
brainmatters-818	45	32	.	.	PUNCT
brainmatters-818	46	1	most	most	ADJ
brainmatters-818	46	2	of	of	ADP
brainmatters-818	46	3	the	the	DET
brainmatters-818	46	4	current	current	ADJ
brainmatters-818	46	5	aso	aso	NOUN
brainmatters-818	46	6	-	-	PUNCT
brainmatters-818	46	7	mediated	mediate	VERB
brainmatters-818	46	8	therapies	therapy	NOUN
brainmatters-818	46	9	work	work	VERB
brainmatters-818	46	10	by	by	ADP
brainmatters-818	46	11	degrading	degrade	VERB
brainmatters-818	46	12	rna	rna	NOUN
brainmatters-818	46	13	;	;	PUNCT
brainmatters-818	46	14	the	the	DET
brainmatters-818	46	15	opposite	opposite	ADJ
brainmatters-818	46	16	,	,	PUNCT
brainmatters-818	46	17	increasing	increase	VERB
brainmatters-818	46	18	rna	rna	NOUN
brainmatters-818	46	19	expression	expression	NOUN
brainmatters-818	46	20	,	,	PUNCT
brainmatters-818	46	21	however	however	ADV
brainmatters-818	46	22	,	,	PUNCT
brainmatters-818	46	23	is	be	AUX
brainmatters-818	46	24	a	a	DET
brainmatters-818	46	25	much	much	ADV
brainmatters-818	46	26	more	more	ADV
brainmatters-818	46	27	complicated	complicated	ADJ
brainmatters-818	46	28	endeavor	endeavor	NOUN
brainmatters-818	46	29	.	.	PUNCT
brainmatters-818	47	1	in	in	ADP
brainmatters-818	47	2	vivo	vivo	NOUN
brainmatters-818	47	3	,	,	PUNCT
brainmatters-818	47	4	increasing	increase	VERB
brainmatters-818	47	5	the	the	DET
brainmatters-818	47	6	levels	level	NOUN
brainmatters-818	47	7	of	of	ADP
brainmatters-818	47	8	proteins	protein	NOUN
brainmatters-818	47	9	is	be	AUX
brainmatters-818	47	10	a	a	DET
brainmatters-818	47	11	delicate	delicate	ADJ
brainmatters-818	47	12	task	task	NOUN
brainmatters-818	47	13	because	because	SCONJ
brainmatters-818	47	14	there	there	PRON
brainmatters-818	47	15	are	be	VERB
brainmatters-818	47	16	not	not	PART
brainmatters-818	47	17	many	many	ADJ
brainmatters-818	47	18	genes	gene	NOUN
brainmatters-818	47	19	to	to	PART
brainmatters-818	47	20	which	which	PRON
brainmatters-818	47	21	this	this	DET
brainmatters-818	47	22	strategy	strategy	NOUN
brainmatters-818	47	23	is	be	AUX
brainmatters-818	47	24	applicable	applicable	ADJ
brainmatters-818	47	25	.	.	PUNCT
brainmatters-818	48	1	gene	gene	NOUN
brainmatters-818	48	2	therapy	therapy	NOUN
brainmatters-818	48	3	and	and	CCONJ
brainmatters-818	48	4	targeting	target	VERB
brainmatters-818	48	5	inhibitory	inhibitory	ADJ
brainmatters-818	48	6	antisense	antisense	NOUN
brainmatters-818	48	7	transcripts	transcript	NOUN
brainmatters-818	48	8	in	in	ADP
brainmatters-818	48	9	a	a	DET
brainmatters-818	48	10	process	process	NOUN
brainmatters-818	48	11	called	call	VERB
brainmatters-818	48	12	antisense	antisense	NOUN
brainmatters-818	48	13	-	-	PUNCT
brainmatters-818	48	14	mediated	mediate	VERB
brainmatters-818	48	15	derepression	derepression	NOUN
brainmatters-818	48	16	are	be	AUX
brainmatters-818	48	17	mechanisms	mechanism	NOUN
brainmatters-818	48	18	of	of	ADP
brainmatters-818	48	19	achieving	achieve	VERB
brainmatters-818	48	20	increased	increase	VERB
brainmatters-818	48	21	protein	protein	NOUN
brainmatters-818	48	22	levels	level	NOUN
brainmatters-818	48	23	,	,	PUNCT
brainmatters-818	48	24	in	in	ADP
brainmatters-818	48	25	vivo	vivo	NOUN
brainmatters-818	48	26	.	.	PUNCT
brainmatters-818	49	1	liang	liang	PROPN
brainmatters-818	49	2	et	et	PROPN
brainmatters-818	49	3	al	al	PROPN
brainmatters-818	49	4	.	.	PROPN
brainmatters-818	50	1	(	(	PUNCT
brainmatters-818	50	2	2016	2016	NUM
brainmatters-818	50	3	)	)	PUNCT
brainmatters-818	50	4	used	use	VERB
brainmatters-818	50	5	asos	asos	NOUN
brainmatters-818	50	6	to	to	PART
brainmatters-818	50	7	increase	increase	VERB
brainmatters-818	50	8	the	the	DET
brainmatters-818	50	9	efficiency	efficiency	NOUN
brainmatters-818	50	10	of	of	ADP
brainmatters-818	50	11	mrna	mrna	PROPN
brainmatters-818	50	12	translation	translation	NOUN
brainmatters-818	50	13	.	.	PUNCT
brainmatters-818	51	1	this	this	DET
brainmatters-818	51	2	study	study	NOUN
brainmatters-818	51	3	used	use	VERB
brainmatters-818	51	4	asos	asos	PROPN
brainmatters-818	51	5	that	that	PRON
brainmatters-818	51	6	targeted	target	VERB
brainmatters-818	51	7	open	open	ADJ
brainmatters-818	51	8	reading	reading	NOUN
brainmatters-818	51	9	frames	frame	NOUN
brainmatters-818	51	10	upstream	upstream	ADV
brainmatters-818	51	11	of	of	ADP
brainmatters-818	51	12	the	the	DET
brainmatters-818	51	13	target	target	NOUN
brainmatters-818	51	14	sequence	sequence	NOUN
brainmatters-818	51	15	to	to	PART
brainmatters-818	51	16	increase	increase	VERB
brainmatters-818	51	17	translation	translation	NOUN
brainmatters-818	51	18	and	and	CCONJ
brainmatters-818	51	19	thus	thus	ADV
brainmatters-818	51	20	increase	increase	VERB
brainmatters-818	51	21	protein	protein	NOUN
brainmatters-818	51	22	levels	level	NOUN
brainmatters-818	51	23	.	.	PUNCT
brainmatters-818	52	1	after	after	ADP
brainmatters-818	52	2	the	the	DET
brainmatters-818	52	3	approval	approval	NOUN
brainmatters-818	52	4	of	of	ADP
brainmatters-818	52	5	aso	aso	NOUN
brainmatters-818	52	6	therapies	therapy	NOUN
brainmatters-818	52	7	for	for	ADP
brainmatters-818	52	8	dmd	dmd	NOUN
brainmatters-818	52	9	and	and	CCONJ
brainmatters-818	52	10	sma	sma	PROPN
brainmatters-818	52	11	,	,	PUNCT
brainmatters-818	52	12	the	the	DET
brainmatters-818	52	13	potential	potential	NOUN
brainmatters-818	52	14	of	of	ADP
brainmatters-818	52	15	asos	asos	PROPN
brainmatters-818	52	16	has	have	AUX
brainmatters-818	52	17	been	be	AUX
brainmatters-818	52	18	significantly	significantly	ADV
brainmatters-818	52	19	broadened	broaden	VERB
brainmatters-818	52	20	.	.	PUNCT
brainmatters-818	53	1	for	for	ADP
brainmatters-818	53	2	example	example	NOUN
brainmatters-818	53	3	,	,	PUNCT
brainmatters-818	53	4	ongoing	ongoing	ADJ
brainmatters-818	53	5	studies	study	NOUN
brainmatters-818	53	6	are	be	AUX
brainmatters-818	53	7	developing	develop	VERB
brainmatters-818	53	8	aso	aso	NOUN
brainmatters-818	53	9	-	-	PUNCT
brainmatters-818	53	10	mediated	mediate	VERB
brainmatters-818	53	11	therapies	therapy	NOUN
brainmatters-818	53	12	for	for	ADP
brainmatters-818	53	13	huntington	huntington	PROPN
brainmatters-818	53	14	’s	’s	PART
brainmatters-818	53	15	and	and	CCONJ
brainmatters-818	53	16	alzheimer	alzheimer	PROPN
brainmatters-818	53	17	’s	’s	PART
brainmatters-818	53	18	.	.	PUNCT
brainmatters-818	54	1	huntington	huntington	PROPN
brainmatters-818	54	2	’s	’s	PART
brainmatters-818	54	3	disease	disease	NOUN
brainmatters-818	54	4	is	be	AUX
brainmatters-818	54	5	caused	cause	VERB
brainmatters-818	54	6	by	by	ADP
brainmatters-818	54	7	repeats	repeat	NOUN
brainmatters-818	54	8	of	of	ADP
brainmatters-818	54	9	the	the	DET
brainmatters-818	54	10	sequence	sequence	NOUN
brainmatters-818	54	11	cag	cag	PROPN
brainmatters-818	54	12	in	in	ADP
brainmatters-818	54	13	the	the	DET
brainmatters-818	54	14	gene	gene	NOUN
brainmatters-818	54	15	htt	htt	NOUN
brainmatters-818	54	16	that	that	PRON
brainmatters-818	54	17	codes	code	VERB
brainmatters-818	54	18	for	for	ADP
brainmatters-818	54	19	a	a	DET
brainmatters-818	54	20	polyglutamine	polyglutamine	NOUN
brainmatters-818	54	21	section	section	NOUN
brainmatters-818	54	22	in	in	ADP
brainmatters-818	54	23	the	the	DET
brainmatters-818	54	24	protein	protein	NOUN
brainmatters-818	54	25	huntingtin	huntingtin	NOUN
brainmatters-818	54	26	.	.	PUNCT
brainmatters-818	55	1	this	this	DET
brainmatters-818	55	2	same	same	ADJ
brainmatters-818	55	3	polyglutamine	polyglutamine	NOUN
brainmatters-818	55	4	section	section	NOUN
brainmatters-818	55	5	is	be	AUX
brainmatters-818	55	6	the	the	DET
brainmatters-818	55	7	site	site	NOUN
brainmatters-818	55	8	of	of	ADP
brainmatters-818	55	9	mutations	mutation	NOUN
brainmatters-818	55	10	that	that	PRON
brainmatters-818	55	11	lead	lead	VERB
brainmatters-818	55	12	to	to	ADP
brainmatters-818	55	13	a	a	DET
brainmatters-818	55	14	number	number	NOUN
brainmatters-818	55	15	of	of	ADP
brainmatters-818	55	16	other	other	ADJ
brainmatters-818	55	17	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	55	18	diseases	disease	NOUN
brainmatters-818	55	19	like	like	ADP
brainmatters-818	55	20	spinocerebellar	spinocerebellar	ADJ
brainmatters-818	55	21	ataxias	ataxia	NOUN
brainmatters-818	55	22	.	.	PUNCT
brainmatters-818	56	1	asos	asos	PROPN
brainmatters-818	56	2	are	be	AUX
brainmatters-818	56	3	being	be	AUX
brainmatters-818	56	4	developed	develop	VERB
brainmatters-818	56	5	to	to	PART
brainmatters-818	56	6	silence	silence	VERB
brainmatters-818	56	7	the	the	DET
brainmatters-818	56	8	cag	cag	PROPN
brainmatters-818	56	9	section	section	NOUN
brainmatters-818	56	10	of	of	ADP
brainmatters-818	56	11	huntingtin	huntingtin	NOUN
brainmatters-818	56	12	,	,	PUNCT
brainmatters-818	56	13	but	but	CCONJ
brainmatters-818	56	14	the	the	DET
brainmatters-818	56	15	issue	issue	NOUN
brainmatters-818	56	16	with	with	ADP
brainmatters-818	56	17	this	this	DET
brainmatters-818	56	18	approach	approach	NOUN
brainmatters-818	56	19	is	be	AUX
brainmatters-818	56	20	that	that	SCONJ
brainmatters-818	56	21	it	it	PRON
brainmatters-818	56	22	may	may	AUX
brainmatters-818	56	23	cause	cause	VERB
brainmatters-818	56	24	downregulation	downregulation	NOUN
brainmatters-818	56	25	of	of	ADP
brainmatters-818	56	26	nontarget	nontarget	NOUN
brainmatters-818	56	27	sequences	sequence	NOUN
brainmatters-818	56	28	that	that	PRON
brainmatters-818	56	29	contain	contain	VERB
brainmatters-818	56	30	cag	cag	PROPN
brainmatters-818	56	31	.	.	PUNCT
brainmatters-818	57	1	other	other	ADJ
brainmatters-818	57	2	approaches	approach	NOUN
brainmatters-818	57	3	include	include	VERB
brainmatters-818	57	4	using	use	VERB
brainmatters-818	57	5	asos	asos	NOUN
brainmatters-818	57	6	to	to	PART
brainmatters-818	57	7	target	target	VERB
brainmatters-818	57	8	the	the	DET
brainmatters-818	57	9	mutated	mutate	VERB
brainmatters-818	57	10	hd	hd	NOUN
brainmatters-818	57	11	allele	allele	NOUN
brainmatters-818	57	12	,	,	PUNCT
brainmatters-818	57	13	specifically	specifically	ADV
brainmatters-818	57	14	polymorphisms	polymorphism	NOUN
brainmatters-818	57	15	of	of	ADP
brainmatters-818	57	16	individual	individual	ADJ
brainmatters-818	57	17	nucleotides	nucleotide	NOUN
brainmatters-818	57	18	,	,	PUNCT
brainmatters-818	57	19	that	that	SCONJ
brainmatters-818	57	20	a	a	DET
brainmatters-818	57	21	large	large	ADJ
brainmatters-818	57	22	majority	majority	NOUN
brainmatters-818	57	23	of	of	ADP
brainmatters-818	57	24	hd	hd	NOUN
brainmatters-818	57	25	patients	patient	NOUN
brainmatters-818	57	26	have	have	VERB
brainmatters-818	57	27	.	.	PUNCT
brainmatters-818	58	1	with	with	ADP
brainmatters-818	58	2	regard	regard	NOUN
brainmatters-818	58	3	to	to	ADP
brainmatters-818	58	4	alzheimer	alzheimer	PROPN
brainmatters-818	58	5	’s	’s	PART
brainmatters-818	58	6	,	,	PUNCT
brainmatters-818	58	7	asos	asos	PROPN
brainmatters-818	58	8	can	can	AUX
brainmatters-818	58	9	be	be	AUX
brainmatters-818	58	10	used	use	VERB
brainmatters-818	58	11	to	to	PART
brainmatters-818	58	12	target	target	VERB
brainmatters-818	58	13	the	the	DET
brainmatters-818	58	14	protein	protein	NOUN
brainmatters-818	58	15	tau	tau	PROPN
brainmatters-818	58	16	.	.	PUNCT
brainmatters-818	59	1	alzheimer	alzheimer	PROPN
brainmatters-818	59	2	’s	’s	PART
brainmatters-818	59	3	falls	fall	VERB
brainmatters-818	59	4	under	under	ADP
brainmatters-818	59	5	the	the	DET
brainmatters-818	59	6	category	category	NOUN
brainmatters-818	59	7	of	of	ADP
brainmatters-818	59	8	tauopathies	tauopathie	NOUN
brainmatters-818	59	9	,	,	PUNCT
brainmatters-818	59	10	where	where	SCONJ
brainmatters-818	59	11	tau	tau	PROPN
brainmatters-818	59	12	is	be	AUX
brainmatters-818	59	13	hyperphosphorylated	hyperphosphorylate	VERB
brainmatters-818	59	14	and	and	CCONJ
brainmatters-818	59	15	accumulates	accumulate	VERB
brainmatters-818	59	16	to	to	PART
brainmatters-818	59	17	form	form	VERB
brainmatters-818	59	18	tangles	tangle	NOUN
brainmatters-818	59	19	in	in	ADP
brainmatters-818	59	20	neurofibers	neurofiber	NOUN
brainmatters-818	59	21	.	.	PUNCT
brainmatters-818	60	1	aso	aso	NOUN
brainmatters-818	60	2	-	-	PUNCT
brainmatters-818	60	3	mediated	mediate	VERB
brainmatters-818	60	4	approaches	approach	NOUN
brainmatters-818	60	5	are	be	AUX
brainmatters-818	60	6	being	be	AUX
brainmatters-818	60	7	developed	develop	VERB
brainmatters-818	60	8	to	to	PART
brainmatters-818	60	9	silence	silence	VERB
brainmatters-818	60	10	tau	tau	PROPN
brainmatters-818	60	11	by	by	ADP
brainmatters-818	60	12	targeting	target	VERB
brainmatters-818	60	13	a	a	DET
brainmatters-818	60	14	number	number	NOUN
brainmatters-818	60	15	of	of	ADP
brainmatters-818	60	16	different	different	ADJ
brainmatters-818	60	17	points	point	NOUN
brainmatters-818	60	18	in	in	ADP
brainmatters-818	60	19	the	the	DET
brainmatters-818	60	20	gene	gene	NOUN
brainmatters-818	60	21	expression	expression	NOUN
brainmatters-818	60	22	pathway	pathway	NOUN
brainmatters-818	60	23	.	.	PUNCT
brainmatters-818	61	1	eteplirsen	eteplirsen	VERB
brainmatters-818	61	2	for	for	ADP
brainmatters-818	61	3	duchenne	duchenne	ADJ
brainmatters-818	61	4	muscular	muscular	ADJ
brainmatters-818	61	5	dystrophy	dystrophy	NOUN
brainmatters-818	61	6	,	,	PUNCT
brainmatters-818	61	7	nusinersen	nusinersen	VERB
brainmatters-818	61	8	for	for	ADP
brainmatters-818	61	9	spinal	spinal	ADJ
brainmatters-818	61	10	muscular	muscular	ADJ
brainmatters-818	61	11	atrophy	atrophy	NOUN
brainmatters-818	61	12	and	and	CCONJ
brainmatters-818	61	13	inotersen	inotersen	VERB
brainmatters-818	61	14	for	for	ADP
brainmatters-818	61	15	familial	familial	ADJ
brainmatters-818	61	16	amyloid	amyloid	NOUN
brainmatters-818	61	17	neuropathy	neuropathy	ADJ
brainmatters-818	61	18	.	.	PUNCT
brainmatters-818	62	1	duchenne	duchenne	PROPN
brainmatters-818	62	2	muscular	muscular	ADJ
brainmatters-818	62	3	dystrophy	dystrophy	NOUN
brainmatters-818	62	4	is	be	AUX
brainmatters-818	62	5	caused	cause	VERB
brainmatters-818	62	6	by	by	ADP
brainmatters-818	62	7	a	a	DET
brainmatters-818	62	8	mutation	mutation	NOUN
brainmatters-818	62	9	in	in	ADP
brainmatters-818	62	10	the	the	DET
brainmatters-818	62	11	gene	gene	NOUN
brainmatters-818	62	12	dmd	dmd	NOUN
brainmatters-818	62	13	(	(	PUNCT
brainmatters-818	62	14	human	human	ADJ
brainmatters-818	62	15	duchenne	duchenne	NOUN
brainmatters-818	62	16	muscular	muscular	ADJ
brainmatters-818	62	17	dystrophy	dystrophy	NOUN
brainmatters-818	62	18	)	)	PUNCT
brainmatters-818	62	19	that	that	PRON
brainmatters-818	62	20	codes	code	VERB
brainmatters-818	62	21	for	for	ADP
brainmatters-818	62	22	the	the	DET
brainmatters-818	62	23	protein	protein	NOUN
brainmatters-818	62	24	dystrophin	dystrophin	NOUN
brainmatters-818	62	25	.	.	PUNCT
brainmatters-818	63	1	usually	usually	ADV
brainmatters-818	63	2	,	,	PUNCT
brainmatters-818	63	3	dmd	dmd	NOUN
brainmatters-818	63	4	mutations	mutation	NOUN
brainmatters-818	63	5	result	result	VERB
brainmatters-818	63	6	in	in	ADP
brainmatters-818	63	7	a	a	DET
brainmatters-818	63	8	premature	premature	ADJ
brainmatters-818	63	9	truncation	truncation	NOUN
brainmatters-818	63	10	of	of	ADP
brainmatters-818	63	11	dystrophin	dystrophin	NOUN
brainmatters-818	63	12	.	.	PUNCT
brainmatters-818	64	1	the	the	DET
brainmatters-818	64	2	aso	aso	NOUN
brainmatters-818	64	3	used	use	VERB
brainmatters-818	64	4	by	by	ADP
brainmatters-818	64	5	eteplirsen	eteplirsen	ADJ
brainmatters-818	64	6	acts	act	NOUN
brainmatters-818	64	7	on	on	ADP
brainmatters-818	64	8	the	the	DET
brainmatters-818	64	9	pre	pre	NOUN
brainmatters-818	64	10	-	-	NOUN
brainmatters-818	64	11	mrna	mrna	NOUN
brainmatters-818	64	12	of	of	ADP
brainmatters-818	64	13	dmd	dmd	PROPN
brainmatters-818	64	14	and	and	CCONJ
brainmatters-818	64	15	excludes	exclude	NOUN
brainmatters-818	64	16	exon	exon	PROPN
brainmatters-818	64	17	51	51	NUM
brainmatters-818	64	18	.	.	PUNCT
brainmatters-818	65	1	this	this	PRON
brainmatters-818	65	2	causes	cause	VERB
brainmatters-818	65	3	a	a	DET
brainmatters-818	65	4	re	re	NOUN
brainmatters-818	65	5	-	-	NOUN
brainmatters-818	65	6	establishment	establishment	NOUN
brainmatters-818	65	7	of	of	ADP
brainmatters-818	65	8	the	the	DET
brainmatters-818	65	9	reading	reading	NOUN
brainmatters-818	65	10	frame	frame	NOUN
brainmatters-818	65	11	and	and	CCONJ
brainmatters-818	65	12	results	result	NOUN
brainmatters-818	65	13	in	in	ADP
brainmatters-818	65	14	partial	partial	ADJ
brainmatters-818	65	15	restoration	restoration	NOUN
brainmatters-818	65	16	of	of	ADP
brainmatters-818	65	17	dmd	dmd	NOUN
brainmatters-818	65	18	function	function	NOUN
brainmatters-818	65	19	.	.	PUNCT
brainmatters-818	66	1	spinal	spinal	ADJ
brainmatters-818	66	2	muscular	muscular	ADJ
brainmatters-818	66	3	atrophy	atrophy	NOUN
brainmatters-818	66	4	(	(	PUNCT
brainmatters-818	66	5	sma	sma	PROPN
brainmatters-818	66	6	)	)	PUNCT
brainmatters-818	66	7	is	be	AUX
brainmatters-818	66	8	the	the	DET
brainmatters-818	66	9	result	result	NOUN
brainmatters-818	66	10	of	of	ADP
brainmatters-818	66	11	a	a	DET
brainmatters-818	66	12	deficiency	deficiency	NOUN
brainmatters-818	66	13	of	of	ADP
brainmatters-818	66	14	the	the	DET
brainmatters-818	66	15	‘	'	PUNCT
brainmatters-818	66	16	survival	survival	NOUN
brainmatters-818	66	17	of	of	ADP
brainmatters-818	66	18	motor	motor	PROPN
brainmatters-818	66	19	neuron	neuron	PROPN
brainmatters-818	66	20	’	'	PUNCT
brainmatters-818	66	21	(	(	PUNCT
brainmatters-818	66	22	smn	smn	NOUN
brainmatters-818	66	23	)	)	PUNCT
brainmatters-818	66	24	protein	protein	NOUN
brainmatters-818	66	25	caused	cause	VERB
brainmatters-818	66	26	by	by	ADP
brainmatters-818	66	27	a	a	DET
brainmatters-818	66	28	loss	loss	NOUN
brainmatters-818	66	29	of	of	ADP
brainmatters-818	66	30	function	function	NOUN
brainmatters-818	66	31	mutation	mutation	NOUN
brainmatters-818	66	32	in	in	ADP
brainmatters-818	66	33	both	both	DET
brainmatters-818	66	34	copies	copy	NOUN
brainmatters-818	66	35	of	of	ADP
brainmatters-818	66	36	the	the	DET
brainmatters-818	66	37	smn1	smn1	NOUN
brainmatters-818	66	38	gene	gene	NOUN
brainmatters-818	66	39	located	locate	VERB
brainmatters-818	66	40	on	on	ADP
brainmatters-818	66	41	chromosome	chromosome	NOUN
brainmatters-818	66	42	5	5	NUM
brainmatters-818	66	43	.	.	PUNCT
brainmatters-818	67	1	in	in	ADP
brainmatters-818	67	2	the	the	DET
brainmatters-818	67	3	treatment	treatment	NOUN
brainmatters-818	67	4	of	of	ADP
brainmatters-818	67	5	spinal	spinal	ADJ
brainmatters-818	67	6	muscular	muscular	ADJ
brainmatters-818	67	7	atrophy	atrophy	NOUN
brainmatters-818	67	8	,	,	PUNCT
brainmatters-818	67	9	the	the	DET
brainmatters-818	67	10	gene	gene	NOUN
brainmatters-818	67	11	smn2	smn2	NOUN
brainmatters-818	67	12	is	be	AUX
brainmatters-818	67	13	targeted	target	VERB
brainmatters-818	67	14	to	to	PART
brainmatters-818	67	15	offset	offset	VERB
brainmatters-818	67	16	the	the	DET
brainmatters-818	67	17	smn	smn	ADJ
brainmatters-818	67	18	protein	protein	NOUN
brainmatters-818	67	19	deficiency	deficiency	NOUN
brainmatters-818	67	20	.	.	PUNCT
brainmatters-818	68	1	smn2	smn2	PROPN
brainmatters-818	68	2	is	be	AUX
brainmatters-818	68	3	a	a	DET
brainmatters-818	68	4	homologous	homologous	ADJ
brainmatters-818	68	5	gene	gene	NOUN
brainmatters-818	68	6	to	to	ADP
brainmatters-818	68	7	smn1	smn1	PROPN
brainmatters-818	68	8	except	except	SCONJ
brainmatters-818	68	9	it	it	PRON
brainmatters-818	68	10	does	do	AUX
brainmatters-818	68	11	not	not	PART
brainmatters-818	68	12	contain	contain	VERB
brainmatters-818	68	13	exon	exon	NOUN
brainmatters-818	68	14	7	7	NUM
brainmatters-818	68	15	.	.	PUNCT
brainmatters-818	69	1	the	the	DET
brainmatters-818	69	2	severity	severity	NOUN
brainmatters-818	69	3	of	of	ADP
brainmatters-818	69	4	sma	sma	NOUN
brainmatters-818	69	5	increases	increase	NOUN
brainmatters-818	69	6	as	as	SCONJ
brainmatters-818	69	7	the	the	DET
brainmatters-818	69	8	copy	copy	NOUN
brainmatters-818	69	9	number	number	NOUN
brainmatters-818	69	10	of	of	ADP
brainmatters-818	69	11	the	the	DET
brainmatters-818	69	12	smn2	smn2	ADJ
brainmatters-818	69	13	gene	gene	NOUN
brainmatters-818	69	14	decreases	decrease	VERB
brainmatters-818	69	15	.	.	PUNCT
brainmatters-818	70	1	the	the	DET
brainmatters-818	70	2	aso	aso	PROPN
brainmatters-818	70	3	nusinersen	nusinersen	PROPN
brainmatters-818	70	4	prevents	prevent	VERB
brainmatters-818	70	5	the	the	DET
brainmatters-818	70	6	splicing	splicing	NOUN
brainmatters-818	70	7	silencer	silencer	NOUN
brainmatters-818	70	8	that	that	PRON
brainmatters-818	70	9	removes	remove	VERB
brainmatters-818	70	10	exon	exon	NOUN
brainmatters-818	70	11	7	7	NUM
brainmatters-818	70	12	from	from	ADP
brainmatters-818	70	13	the	the	DET
brainmatters-818	70	14	smn2	smn2	ADJ
brainmatters-818	70	15	gene	gene	NOUN
brainmatters-818	70	16	.	.	PUNCT
brainmatters-818	71	1	as	as	ADP
brainmatters-818	71	2	a	a	DET
brainmatters-818	71	3	result	result	NOUN
brainmatters-818	71	4	,	,	PUNCT
brainmatters-818	71	5	the	the	DET
brainmatters-818	71	6	smn2	smn2	ADJ
brainmatters-818	71	7	gene	gene	NOUN
brainmatters-818	71	8	produces	produce	VERB
brainmatters-818	71	9	the	the	DET
brainmatters-818	71	10	smn	smn	PROPN
brainmatters-818	71	11	protein	protein	NOUN
brainmatters-818	71	12	.	.	PUNCT
brainmatters-818	72	1	challenges	challenge	NOUN
brainmatters-818	72	2	in	in	ADP
brainmatters-818	72	3	clinical	clinical	ADJ
brainmatters-818	72	4	application	application	NOUN
brainmatters-818	72	5	while	while	SCONJ
brainmatters-818	72	6	some	some	DET
brainmatters-818	72	7	successful	successful	ADJ
brainmatters-818	72	8	therapies	therapy	NOUN
brainmatters-818	72	9	have	have	AUX
brainmatters-818	72	10	been	be	AUX
brainmatters-818	72	11	developed	develop	VERB
brainmatters-818	72	12	,	,	PUNCT
brainmatters-818	72	13	one	one	NUM
brainmatters-818	72	14	of	of	ADP
brainmatters-818	72	15	the	the	DET
brainmatters-818	72	16	main	main	ADJ
brainmatters-818	72	17	issues	issue	NOUN
brainmatters-818	72	18	in	in	ADP
brainmatters-818	72	19	using	use	VERB
brainmatters-818	72	20	aso	aso	NOUN
brainmatters-818	72	21	-	-	PUNCT
brainmatters-818	72	22	mediated	mediate	VERB
brainmatters-818	72	23	therapies	therapy	NOUN
brainmatters-818	72	24	for	for	ADP
brainmatters-818	72	25	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	72	26	disorders	disorder	NOUN
brainmatters-818	72	27	is	be	AUX
brainmatters-818	72	28	effective	effective	ADJ
brainmatters-818	72	29	delivery	delivery	NOUN
brainmatters-818	72	30	of	of	ADP
brainmatters-818	72	31	the	the	DET
brainmatters-818	72	32	drug	drug	NOUN
brainmatters-818	72	33	to	to	ADP
brainmatters-818	72	34	the	the	DET
brainmatters-818	72	35	brain	brain	NOUN
brainmatters-818	72	36	.	.	PUNCT
brainmatters-818	73	1	antisense	antisense	NOUN
brainmatters-818	73	2	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	73	3	are	be	AUX
brainmatters-818	73	4	too	too	ADV
brainmatters-818	73	5	large	large	ADJ
brainmatters-818	73	6	to	to	PART
brainmatters-818	73	7	cross	cross	VERB
brainmatters-818	73	8	the	the	DET
brainmatters-818	73	9	blood	blood	NOUN
brainmatters-818	73	10	brain	brain	NOUN
brainmatters-818	73	11	barrier	barrier	NOUN
brainmatters-818	73	12	.	.	PUNCT
brainmatters-818	74	1	in	in	ADP
brainmatters-818	74	2	order	order	NOUN
brainmatters-818	74	3	to	to	PART
brainmatters-818	74	4	reach	reach	VERB
brainmatters-818	74	5	the	the	DET
brainmatters-818	74	6	brain	brain	NOUN
brainmatters-818	74	7	,	,	PUNCT
brainmatters-818	74	8	the	the	DET
brainmatters-818	74	9	therapy	therapy	NOUN
brainmatters-818	74	10	is	be	AUX
brainmatters-818	74	11	delivered	deliver	VERB
brainmatters-818	74	12	through	through	ADP
brainmatters-818	74	13	the	the	DET
brainmatters-818	74	14	spinal	spinal	ADJ
brainmatters-818	74	15	cord	cord	NOUN
brainmatters-818	74	16	by	by	ADP
brainmatters-818	74	17	injection	injection	NOUN
brainmatters-818	74	18	into	into	ADP
brainmatters-818	74	19	the	the	DET
brainmatters-818	74	20	cerebrospinal	cerebrospinal	ADJ
brainmatters-818	74	21	fluid.the	fluid.the	DET
brainmatters-818	74	22	spinal	spinal	ADJ
brainmatters-818	74	23	cord	cord	NOUN
brainmatters-818	74	24	is	be	AUX
brainmatters-818	74	25	the	the	DET
brainmatters-818	74	26	pathway	pathway	NOUN
brainmatters-818	74	27	of	of	ADP
brainmatters-818	74	28	delivery	delivery	NOUN
brainmatters-818	74	29	that	that	PRON
brainmatters-818	74	30	must	must	AUX
brainmatters-818	74	31	be	be	AUX
brainmatters-818	74	32	used	use	VERB
brainmatters-818	74	33	.	.	PUNCT
brainmatters-818	75	1	cerebrospinal	cerebrospinal	ADJ
brainmatters-818	75	2	fluid	fluid	NOUN
brainmatters-818	75	3	(	(	PUNCT
brainmatters-818	75	4	csf	csf	NOUN
brainmatters-818	75	5	)	)	PUNCT
brainmatters-818	75	6	is	be	AUX
brainmatters-818	75	7	produced	produce	VERB
brainmatters-818	75	8	by	by	ADP
brainmatters-818	75	9	the	the	DET
brainmatters-818	75	10	choroid	choroid	NOUN
brainmatters-818	75	11	plexus	plexus	NOUN
brainmatters-818	75	12	and	and	CCONJ
brainmatters-818	75	13	is	be	AUX
brainmatters-818	75	14	stored	store	VERB
brainmatters-818	75	15	in	in	ADP
brainmatters-818	75	16	cerebral	cerebral	ADJ
brainmatters-818	75	17	ventricles	ventricle	NOUN
brainmatters-818	75	18	in	in	ADP
brainmatters-818	75	19	the	the	DET
brainmatters-818	75	20	brain	brain	NOUN
brainmatters-818	75	21	as	as	ADV
brainmatters-818	75	22	well	well	ADV
brainmatters-818	75	23	as	as	ADP
brainmatters-818	75	24	in	in	ADP
brainmatters-818	75	25	the	the	DET
brainmatters-818	75	26	spinal	spinal	NOUN
brainmatters-818	75	27	cord	cord	NOUN
brainmatters-818	75	28	.	.	PUNCT
brainmatters-818	76	1	asos	asos	PROPN
brainmatters-818	76	2	can	can	AUX
brainmatters-818	76	3	be	be	AUX
brainmatters-818	76	4	safely	safely	ADV
brainmatters-818	76	5	administered	administer	VERB
brainmatters-818	76	6	by	by	ADP
brainmatters-818	76	7	injecting	inject	VERB
brainmatters-818	76	8	them	they	PRON
brainmatters-818	76	9	directly	directly	ADV
brainmatters-818	76	10	into	into	ADP
brainmatters-818	76	11	csf	csf	NOUN
brainmatters-818	76	12	in	in	ADP
brainmatters-818	76	13	the	the	DET
brainmatters-818	76	14	spinal	spinal	NOUN
brainmatters-818	76	15	cord	cord	NOUN
brainmatters-818	76	16	.	.	PUNCT
brainmatters-818	77	1	the	the	DET
brainmatters-818	77	2	first	first	ADJ
brainmatters-818	77	3	phase	phase	NOUN
brainmatters-818	77	4	of	of	ADP
brainmatters-818	77	5	human	human	ADJ
brainmatters-818	77	6	clinical	clinical	ADJ
brainmatters-818	77	7	testing	testing	NOUN
brainmatters-818	77	8	of	of	ADP
brainmatters-818	77	9	an	an	DET
brainmatters-818	77	10	aso	aso	NOUN
brainmatters-818	77	11	targeting	target	VERB
brainmatters-818	77	12	the	the	DET
brainmatters-818	77	13	gene	gene	NOUN
brainmatters-818	77	14	sod1	sod1	NOUN
brainmatters-818	77	15	showed	show	VERB
brainmatters-818	77	16	that	that	SCONJ
brainmatters-818	77	17	the	the	DET
brainmatters-818	77	18	drug	drug	NOUN
brainmatters-818	77	19	was	be	AUX
brainmatters-818	77	20	successfully	successfully	ADV
brainmatters-818	77	21	and	and	CCONJ
brainmatters-818	77	22	safely	safely	ADV
brainmatters-818	77	23	injected	inject	VERB
brainmatters-818	77	24	into	into	ADP
brainmatters-818	77	25	the	the	DET
brainmatters-818	77	26	csf	csf	NOUN
brainmatters-818	77	27	but	but	CCONJ
brainmatters-818	77	28	only	only	ADV
brainmatters-818	77	29	reduced	reduce	VERB
brainmatters-818	77	30	the	the	DET
brainmatters-818	77	31	mutant	mutant	ADJ
brainmatters-818	77	32	sod1	sod1	ADJ
brainmatters-818	77	33	protein	protein	NOUN
brainmatters-818	77	34	expression	expression	NOUN
brainmatters-818	77	35	by	by	ADP
brainmatters-818	77	36	about	about	ADV
brainmatters-818	77	37	12	12	NUM
brainmatters-818	77	38	%	%	NOUN
brainmatters-818	77	39	.	.	PUNCT
brainmatters-818	78	1	there	there	PRON
brainmatters-818	78	2	is	be	VERB
brainmatters-818	78	3	also	also	ADV
brainmatters-818	78	4	the	the	DET
brainmatters-818	78	5	issue	issue	NOUN
brainmatters-818	78	6	of	of	ADP
brainmatters-818	78	7	sustainability	sustainability	NOUN
brainmatters-818	78	8	for	for	ADP
brainmatters-818	78	9	long	long	ADJ
brainmatters-818	78	10	term	term	NOUN
brainmatters-818	78	11	usage	usage	NOUN
brainmatters-818	78	12	of	of	ADP
brainmatters-818	78	13	aso	aso	NOUN
brainmatters-818	78	14	-	-	PUNCT
brainmatters-818	78	15	mediated	mediate	VERB
brainmatters-818	78	16	therapies	therapy	NOUN
brainmatters-818	78	17	.	.	PUNCT
brainmatters-818	79	1	chemically	chemically	ADV
brainmatters-818	79	2	modified	modify	VERB
brainmatters-818	79	3	asos	asos	NOUN
brainmatters-818	79	4	can	can	AUX
brainmatters-818	79	5	have	have	VERB
brainmatters-818	79	6	longer	long	ADJ
brainmatters-818	79	7	half	half	ADJ
brainmatters-818	79	8	-	-	PUNCT
brainmatters-818	79	9	lives	life	NOUN
brainmatters-818	79	10	.	.	PUNCT
brainmatters-818	80	1	for	for	ADP
brainmatters-818	80	2	example	example	NOUN
brainmatters-818	80	3	,	,	PUNCT
brainmatters-818	80	4	the	the	DET
brainmatters-818	80	5	modification	modification	NOUN
brainmatters-818	80	6	2’o’methoxyethyl	2’o’methoxyethyl	NOUN
brainmatters-818	80	7	can	can	AUX
brainmatters-818	80	8	be	be	AUX
brainmatters-818	80	9	added	add	VERB
brainmatters-818	80	10	to	to	ADP
brainmatters-818	80	11	asos	asos	PROPN
brainmatters-818	80	12	.	.	PUNCT
brainmatters-818	81	1	this	this	PRON
brainmatters-818	81	2	increases	increase	VERB
brainmatters-818	81	3	binding	bind	VERB
brainmatters-818	81	4	affinity	affinity	NOUN
brainmatters-818	81	5	to	to	ADP
brainmatters-818	81	6	mrna	mrna	PROPN
brainmatters-818	81	7	and	and	CCONJ
brainmatters-818	81	8	has	have	VERB
brainmatters-818	81	9	a	a	DET
brainmatters-818	81	10	half	half	ADJ
brainmatters-818	81	11	life	life	NOUN
brainmatters-818	81	12	of	of	ADP
brainmatters-818	81	13	6	6	NUM
brainmatters-818	81	14	months	month	NOUN
brainmatters-818	81	15	or	or	CCONJ
brainmatters-818	81	16	more	more	ADJ
brainmatters-818	81	17	.	.	PUNCT
brainmatters-818	82	1	aso	aso	NOUN
brainmatters-818	82	2	-	-	PUNCT
brainmatters-818	82	3	mediated	mediate	VERB
brainmatters-818	82	4	therapies	therapy	NOUN
brainmatters-818	82	5	are	be	AUX
brainmatters-818	82	6	still	still	ADV
brainmatters-818	82	7	relatively	relatively	ADV
brainmatters-818	82	8	new	new	ADJ
brainmatters-818	82	9	and	and	CCONJ
brainmatters-818	82	10	many	many	ADJ
brainmatters-818	82	11	improvements	improvement	NOUN
brainmatters-818	82	12	need	need	VERB
brainmatters-818	82	13	to	to	PART
brainmatters-818	82	14	be	be	AUX
brainmatters-818	82	15	made	make	VERB
brainmatters-818	82	16	to	to	ADP
brainmatters-818	82	17	existing	exist	VERB
brainmatters-818	82	18	therapies	therapy	NOUN
brainmatters-818	82	19	before	before	SCONJ
brainmatters-818	82	20	they	they	PRON
brainmatters-818	82	21	can	can	AUX
brainmatters-818	82	22	be	be	AUX
brainmatters-818	82	23	considered	consider	VERB
brainmatters-818	82	24	a	a	DET
brainmatters-818	82	25	standard	standard	ADJ
brainmatters-818	82	26	treatment	treatment	NOUN
brainmatters-818	82	27	.	.	PUNCT
brainmatters-818	83	1	improving	improve	VERB
brainmatters-818	83	2	the	the	DET
brainmatters-818	83	3	specificity	specificity	NOUN
brainmatters-818	83	4	to	to	ADP
brainmatters-818	83	5	targets	target	NOUN
brainmatters-818	83	6	is	be	AUX
brainmatters-818	83	7	very	very	ADV
brainmatters-818	83	8	important	important	ADJ
brainmatters-818	83	9	to	to	PART
brainmatters-818	83	10	prevent	prevent	VERB
brainmatters-818	83	11	any	any	DET
brainmatters-818	83	12	off	off	ADP
brainmatters-818	83	13	-	-	PUNCT
brainmatters-818	83	14	target	target	NOUN
brainmatters-818	83	15	effects	effect	NOUN
brainmatters-818	83	16	.	.	PUNCT
brainmatters-818	84	1	during	during	ADP
brainmatters-818	84	2	the	the	DET
brainmatters-818	84	3	development	development	NOUN
brainmatters-818	84	4	of	of	ADP
brainmatters-818	84	5	asos	asos	PROPN
brainmatters-818	84	6	,	,	PUNCT
brainmatters-818	84	7	two	two	NUM
brainmatters-818	84	8	main	main	ADJ
brainmatters-818	84	9	methods	method	NOUN
brainmatters-818	84	10	are	be	AUX
brainmatters-818	84	11	used	use	VERB
brainmatters-818	84	12	to	to	PART
brainmatters-818	84	13	study	study	VERB
brainmatters-818	84	14	and	and	CCONJ
brainmatters-818	84	15	improve	improve	VERB
brainmatters-818	84	16	specificity	specificity	NOUN
brainmatters-818	84	17	.	.	PUNCT
brainmatters-818	85	1	the	the	DET
brainmatters-818	85	2	first	first	ADJ
brainmatters-818	85	3	is	be	AUX
brainmatters-818	85	4	quantitative	quantitative	ADJ
brainmatters-818	85	5	pcr	pcr	NOUN
brainmatters-818	85	6	to	to	PART
brainmatters-818	85	7	appraise	appraise	VERB
brainmatters-818	85	8	the	the	DET
brainmatters-818	85	9	mrna	mrna	PROPN
brainmatters-818	85	10	expression	expression	NOUN
brainmatters-818	85	11	when	when	SCONJ
brainmatters-818	85	12	treated	treat	VERB
brainmatters-818	85	13	with	with	ADP
brainmatters-818	85	14	asos	asos	PROPN
brainmatters-818	85	15	.	.	PUNCT
brainmatters-818	86	1	this	this	DET
brainmatters-818	86	2	method	method	NOUN
brainmatters-818	86	3	can	can	AUX
brainmatters-818	86	4	be	be	AUX
brainmatters-818	86	5	used	use	VERB
brainmatters-818	86	6	to	to	PART
brainmatters-818	86	7	study	study	VERB
brainmatters-818	86	8	where	where	SCONJ
brainmatters-818	86	9	mismatches	mismatch	NOUN
brainmatters-818	86	10	occurred	occur	VERB
brainmatters-818	86	11	and	and	CCONJ
brainmatters-818	86	12	whether	whether	SCONJ
brainmatters-818	86	13	or	or	CCONJ
brainmatters-818	86	14	not	not	PART
brainmatters-818	86	15	the	the	DET
brainmatters-818	86	16	mismatched	mismatched	ADJ
brainmatters-818	86	17	binding	bind	VERB
brainmatters-818	86	18	to	to	ADP
brainmatters-818	86	19	the	the	DET
brainmatters-818	86	20	aso	aso	NOUN
brainmatters-818	86	21	resulted	result	VERB
brainmatters-818	86	22	in	in	ADP
brainmatters-818	86	23	any	any	DET
brainmatters-818	86	24	changes	change	NOUN
brainmatters-818	86	25	in	in	ADP
brainmatters-818	86	26	gene	gene	NOUN
brainmatters-818	86	27	expression	expression	NOUN
brainmatters-818	86	28	of	of	ADP
brainmatters-818	86	29	the	the	DET
brainmatters-818	86	30	target	target	NOUN
brainmatters-818	86	31	.	.	PUNCT
brainmatters-818	87	1	the	the	DET
brainmatters-818	87	2	second	second	ADJ
brainmatters-818	87	3	method	method	NOUN
brainmatters-818	87	4	is	be	AUX
brainmatters-818	87	5	transcriptome	transcriptome	ADJ
brainmatters-818	87	6	analysis	analysis	NOUN
brainmatters-818	87	7	or	or	CCONJ
brainmatters-818	87	8	rna	rna	NOUN
brainmatters-818	87	9	-	-	PUNCT
brainmatters-818	87	10	sequencing	sequencing	NOUN
brainmatters-818	87	11	of	of	ADP
brainmatters-818	87	12	mouse	mouse	NOUN
brainmatters-818	87	13	tissues	tissue	NOUN
brainmatters-818	87	14	.	.	PUNCT
brainmatters-818	88	1	the	the	DET
brainmatters-818	88	2	tissues	tissue	NOUN
brainmatters-818	88	3	extracted	extract	VERB
brainmatters-818	88	4	from	from	ADP
brainmatters-818	88	5	mice	mouse	NOUN
brainmatters-818	88	6	do	do	AUX
brainmatters-818	88	7	not	not	PART
brainmatters-818	88	8	have	have	VERB
brainmatters-818	88	9	the	the	DET
brainmatters-818	88	10	mrna	mrna	PROPN
brainmatters-818	88	11	target	target	NOUN
brainmatters-818	88	12	and	and	CCONJ
brainmatters-818	88	13	are	be	AUX
brainmatters-818	88	14	studied	study	VERB
brainmatters-818	88	15	for	for	ADP
brainmatters-818	88	16	expression	expression	NOUN
brainmatters-818	88	17	changes	change	NOUN
brainmatters-818	88	18	when	when	SCONJ
brainmatters-818	88	19	treated	treat	VERB
brainmatters-818	88	20	with	with	ADP
brainmatters-818	88	21	the	the	DET
brainmatters-818	88	22	aso	aso	PROPN
brainmatters-818	88	23	.	.	PUNCT
brainmatters-818	89	1	aso	aso	PROPN
brainmatters-818	89	2	-	-	PUNCT
brainmatters-818	89	3	mediated	mediate	VERB
brainmatters-818	89	4	therapies	therapy	NOUN
brainmatters-818	89	5	can	can	AUX
brainmatters-818	89	6	also	also	ADV
brainmatters-818	89	7	be	be	AUX
brainmatters-818	89	8	modified	modify	VERB
brainmatters-818	89	9	to	to	PART
brainmatters-818	89	10	enhance	enhance	VERB
brainmatters-818	89	11	their	their	PRON
brainmatters-818	89	12	pharmacokinetic	pharmacokinetic	ADJ
brainmatters-818	89	13	properties	property	NOUN
brainmatters-818	89	14	like	like	ADP
brainmatters-818	89	15	binding	bind	VERB
brainmatters-818	89	16	affinity	affinity	NOUN
brainmatters-818	89	17	and	and	CCONJ
brainmatters-818	89	18	resistance	resistance	NOUN
brainmatters-818	89	19	to	to	ADP
brainmatters-818	89	20	endogenous	endogenous	ADJ
brainmatters-818	89	21	nucleases	nuclease	NOUN
brainmatters-818	89	22	.	.	PUNCT
brainmatters-818	90	1	for	for	ADP
brainmatters-818	90	2	example	example	NOUN
brainmatters-818	90	3	,	,	PUNCT
brainmatters-818	90	4	brain	brain	NOUN
brainmatters-818	90	5	matters・volume	matters・volume	NOUN
brainmatters-818	90	6	v	v	ADP
brainmatters-818	90	7	12	12	NUM
brainmatters-818	90	8	this	this	PRON
brainmatters-818	90	9	includes	include	VERB
brainmatters-818	90	10	binding	bind	VERB
brainmatters-818	90	11	and	and	CCONJ
brainmatters-818	90	12	blocking	block	VERB
brainmatters-818	90	13	the	the	DET
brainmatters-818	90	14	start	start	NOUN
brainmatters-818	90	15	codon	codon	NOUN
brainmatters-818	90	16	,	,	PUNCT
brainmatters-818	90	17	splice	splice	NOUN
brainmatters-818	90	18	factors	factor	NOUN
brainmatters-818	90	19	or	or	CCONJ
brainmatters-818	90	20	sequences	sequence	NOUN
brainmatters-818	90	21	.	.	PUNCT
brainmatters-818	91	1	so	so	ADV
brainmatters-818	91	2	far	far	ADV
brainmatters-818	91	3	,	,	PUNCT
brainmatters-818	91	4	the	the	DET
brainmatters-818	91	5	most	most	ADV
brainmatters-818	91	6	successful	successful	ADJ
brainmatters-818	91	7	approach	approach	NOUN
brainmatters-818	91	8	has	have	AUX
brainmatters-818	91	9	involved	involve	VERB
brainmatters-818	91	10	using	use	VERB
brainmatters-818	91	11	asos	asos	NOUN
brainmatters-818	91	12	to	to	PART
brainmatters-818	91	13	create	create	VERB
brainmatters-818	91	14	an	an	DET
brainmatters-818	91	15	out	out	ADV
brainmatters-818	91	16	-	-	PUNCT
brainmatters-818	91	17	of	of	ADP
brainmatters-818	91	18	-	-	PUNCT
brainmatters-818	91	19	frame	frame	NOUN
brainmatters-818	91	20	deletion	deletion	NOUN
brainmatters-818	91	21	by	by	ADP
brainmatters-818	91	22	skipping	skip	VERB
brainmatters-818	91	23	specific	specific	ADJ
brainmatters-818	91	24	exons	exon	NOUN
brainmatters-818	91	25	that	that	PRON
brainmatters-818	91	26	ultimately	ultimately	ADV
brainmatters-818	91	27	reduces	reduce	VERB
brainmatters-818	91	28	tau	tau	PROPN
brainmatters-818	91	29	protein	protein	NOUN
brainmatters-818	91	30	levels	level	NOUN
brainmatters-818	91	31	.	.	PUNCT
brainmatters-818	92	1	concluding	conclude	VERB
brainmatters-818	92	2	statements	statement	NOUN
brainmatters-818	92	3	aso	aso	NOUN
brainmatters-818	92	4	-	-	PUNCT
brainmatters-818	92	5	mediated	mediate	VERB
brainmatters-818	92	6	therapies	therapy	NOUN
brainmatters-818	92	7	have	have	AUX
brainmatters-818	92	8	shown	show	VERB
brainmatters-818	92	9	to	to	PART
brainmatters-818	92	10	be	be	AUX
brainmatters-818	92	11	a	a	DET
brainmatters-818	92	12	novel	novel	ADJ
brainmatters-818	92	13	approach	approach	NOUN
brainmatters-818	92	14	to	to	ADP
brainmatters-818	92	15	treating	treat	VERB
brainmatters-818	92	16	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	92	17	diseases	disease	NOUN
brainmatters-818	92	18	.	.	PUNCT
brainmatters-818	93	1	a	a	DET
brainmatters-818	93	2	lot	lot	NOUN
brainmatters-818	93	3	of	of	ADP
brainmatters-818	93	4	development	development	NOUN
brainmatters-818	93	5	and	and	CCONJ
brainmatters-818	93	6	further	further	ADJ
brainmatters-818	93	7	research	research	NOUN
brainmatters-818	93	8	needs	need	VERB
brainmatters-818	93	9	to	to	PART
brainmatters-818	93	10	be	be	AUX
brainmatters-818	93	11	done	do	VERB
brainmatters-818	93	12	to	to	PART
brainmatters-818	93	13	broaden	broaden	VERB
brainmatters-818	93	14	the	the	DET
brainmatters-818	93	15	scope	scope	NOUN
brainmatters-818	93	16	of	of	ADP
brainmatters-818	93	17	applications	application	NOUN
brainmatters-818	93	18	of	of	ADP
brainmatters-818	93	19	this	this	DET
brainmatters-818	93	20	therapeutic	therapeutic	ADJ
brainmatters-818	93	21	strategy	strategy	NOUN
brainmatters-818	93	22	.	.	PUNCT
brainmatters-818	94	1	asos	asos	PROPN
brainmatters-818	94	2	,	,	PUNCT
brainmatters-818	94	3	as	as	ADP
brainmatters-818	94	4	a	a	DET
brainmatters-818	94	5	new	new	ADJ
brainmatters-818	94	6	therapy	therapy	NOUN
brainmatters-818	94	7	,	,	PUNCT
brainmatters-818	94	8	have	have	VERB
brainmatters-818	94	9	a	a	DET
brainmatters-818	94	10	lot	lot	NOUN
brainmatters-818	94	11	of	of	ADP
brainmatters-818	94	12	room	room	NOUN
brainmatters-818	94	13	for	for	ADP
brainmatters-818	94	14	improving	improve	VERB
brainmatters-818	94	15	specificity	specificity	NOUN
brainmatters-818	94	16	,	,	PUNCT
brainmatters-818	94	17	efficiency	efficiency	NOUN
brainmatters-818	94	18	,	,	PUNCT
brainmatters-818	94	19	and	and	CCONJ
brainmatters-818	94	20	rates	rate	NOUN
brainmatters-818	94	21	of	of	ADP
brainmatters-818	94	22	activity	activity	NOUN
brainmatters-818	94	23	.	.	PUNCT
brainmatters-818	95	1	further	further	ADJ
brainmatters-818	95	2	research	research	NOUN
brainmatters-818	95	3	needs	need	VERB
brainmatters-818	95	4	to	to	PART
brainmatters-818	95	5	be	be	AUX
brainmatters-818	95	6	done	do	VERB
brainmatters-818	95	7	on	on	ADP
brainmatters-818	95	8	enhancing	enhance	VERB
brainmatters-818	95	9	aso	aso	NOUN
brainmatters-818	95	10	selectivity	selectivity	PROPN
brainmatters-818	95	11	without	without	ADP
brainmatters-818	95	12	increased	increase	VERB
brainmatters-818	95	13	offtarget	offtarget	NOUN
brainmatters-818	95	14	binding	bind	VERB
brainmatters-818	95	15	.	.	PUNCT
brainmatters-818	96	1	as	as	SCONJ
brainmatters-818	96	2	asos	asos	PROPN
brainmatters-818	96	3	become	become	VERB
brainmatters-818	96	4	a	a	DET
brainmatters-818	96	5	more	more	ADV
brainmatters-818	96	6	prominent	prominent	ADJ
brainmatters-818	96	7	method	method	NOUN
brainmatters-818	96	8	of	of	ADP
brainmatters-818	96	9	treating	treat	VERB
brainmatters-818	96	10	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	96	11	diseases	disease	NOUN
brainmatters-818	96	12	,	,	PUNCT
brainmatters-818	96	13	it	it	PRON
brainmatters-818	96	14	is	be	AUX
brainmatters-818	96	15	important	important	ADJ
brainmatters-818	96	16	to	to	PART
brainmatters-818	96	17	study	study	VERB
brainmatters-818	96	18	its	its	PRON
brainmatters-818	96	19	applications	application	NOUN
brainmatters-818	96	20	to	to	ADP
brainmatters-818	96	21	non	non	ADJ
brainmatters-818	96	22	-	-	ADJ
brainmatters-818	96	23	neurological	neurological	ADJ
brainmatters-818	96	24	disorders	disorder	NOUN
brainmatters-818	96	25	.	.	PUNCT
brainmatters-818	97	1	bibliography	bibliography	NOUN
brainmatters-818	97	2	bennett	bennett	PROPN
brainmatters-818	97	3	,	,	PUNCT
brainmatters-818	97	4	c.	c.	PROPN
brainmatters-818	97	5	frank	frank	PROPN
brainmatters-818	97	6	,	,	PUNCT
brainmatters-818	97	7	and	and	CCONJ
brainmatters-818	97	8	eric	eric	PROPN
brainmatters-818	97	9	e.	e.	PROPN
brainmatters-818	97	10	swayze	swayze	PROPN
brainmatters-818	97	11	.	.	PUNCT
brainmatters-818	98	1	“	"	PUNCT
brainmatters-818	98	2	rna	rna	VERB
brainmatters-818	98	3	targeting	target	VERB
brainmatters-818	98	4	therapeutics	therapeutic	NOUN
brainmatters-818	98	5	:	:	PUNCT
brainmatters-818	98	6	molecular	molecular	ADJ
brainmatters-818	98	7	mechanisms	mechanism	NOUN
brainmatters-818	98	8	of	of	ADP
brainmatters-818	98	9	antisense	antisense	NOUN
brainmatters-818	98	10	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	98	11	as	as	ADP
brainmatters-818	98	12	a	a	DET
brainmatters-818	98	13	therapeutic	therapeutic	ADJ
brainmatters-818	98	14	platform	platform	NOUN
brainmatters-818	98	15	.	.	PUNCT
brainmatters-818	98	16	”	"	PUNCT
brainmatters-818	99	1	annual	annual	ADJ
brainmatters-818	99	2	review	review	NOUN
brainmatters-818	99	3	of	of	ADP
brainmatters-818	99	4	pharmacology	pharmacology	NOUN
brainmatters-818	99	5	and	and	CCONJ
brainmatters-818	99	6	toxicology	toxicology	NOUN
brainmatters-818	99	7	,	,	PUNCT
brainmatters-818	99	8	vol	vol	NOUN
brainmatters-818	99	9	.	.	PROPN
brainmatters-818	100	1	50	50	NUM
brainmatters-818	100	2	,	,	PUNCT
brainmatters-818	100	3	no	no	INTJ
brainmatters-818	100	4	.	.	NOUN
brainmatters-818	100	5	1	1	NUM
brainmatters-818	100	6	,	,	PUNCT
brainmatters-818	100	7	2010	2010	NUM
brainmatters-818	100	8	,	,	PUNCT
brainmatters-818	100	9	pp	pp	ADJ
brainmatters-818	100	10	.	.	PUNCT
brainmatters-818	101	1	259–293	259–293	NUM
brainmatters-818	101	2	.	.	NUM
brainmatters-818	101	3	,	,	PUNCT
brainmatters-818	101	4	doi:10.1146	doi:10.1146	NOUN
brainmatters-818	101	5	/	/	SYM
brainmatters-818	101	6	annurev.pharmtox.010909.105654	annurev.pharmtox.010909.105654	PROPN
brainmatters-818	101	7	.	.	PUNCT
brainmatters-818	102	1	daniel	daniel	PROPN
brainmatters-818	102	2	r.	r.	PROPN
brainmatters-818	102	3	scoles	scoles	PROPN
brainmatters-818	102	4	,	,	PUNCT
brainmatters-818	102	5	eric	eric	PROPN
brainmatters-818	102	6	v.	v.	PROPN
brainmatters-818	102	7	minikel	minikel	PROPN
brainmatters-818	102	8	,	,	PUNCT
brainmatters-818	102	9	stefan	stefan	PROPN
brainmatters-818	102	10	m.	m.	PROPN
brainmatters-818	102	11	pulst	pulst	PROPN
brainmatters-818	102	12	,	,	PUNCT
brainmatters-818	102	13	neurol	neurol	PROPN
brainmatters-818	102	14	genet	genet	PROPN
brainmatters-818	102	15	apr	apr	PROPN
brainmatters-818	102	16	2019	2019	NUM
brainmatters-818	102	17	,	,	PUNCT
brainmatters-818	102	18	5	5	NUM
brainmatters-818	102	19	(	(	PUNCT
brainmatters-818	102	20	2	2	NUM
brainmatters-818	102	21	)	)	PUNCT
brainmatters-818	102	22	e323	e323	PROPN
brainmatters-818	102	23	.	.	PUNCT
brainmatters-818	103	1	doi	doi	PROPN
brainmatters-818	103	2	:	:	PUNCT
brainmatters-818	103	3	:	:	PUNCT
brainmatters-818	103	4	10.1212	10.1212	NUM
brainmatters-818	103	5	/	/	SYM
brainmatters-818	103	6	nxg.0000000000000323	nxg.0000000000000323	NUM
brainmatters-818	103	7	liang	liang	PROPN
brainmatters-818	103	8	,	,	PUNCT
brainmatters-818	103	9	xue	xue	PROPN
brainmatters-818	103	10	-	-	PUNCT
brainmatters-818	103	11	hai	hai	PROPN
brainmatters-818	103	12	,	,	PUNCT
brainmatters-818	103	13	and	and	CCONJ
brainmatters-818	103	14	wen	wen	PROPN
brainmatters-818	103	15	shen	shen	PROPN
brainmatters-818	103	16	.	.	PUNCT
brainmatters-818	104	1	“	"	PUNCT
brainmatters-818	104	2	translation	translation	NOUN
brainmatters-818	104	3	efficiency	efficiency	NOUN
brainmatters-818	104	4	of	of	ADP
brainmatters-818	104	5	mrnas	mrna	NOUN
brainmatters-818	104	6	is	be	AUX
brainmatters-818	104	7	increased	increase	VERB
brainmatters-818	104	8	by	by	ADP
brainmatters-818	104	9	antisense	antisense	NOUN
brainmatters-818	104	10	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	104	11	targeting	target	VERB
brainmatters-818	104	12	upstream	upstream	ADJ
brainmatters-818	104	13	open	open	ADJ
brainmatters-818	104	14	reading	reading	NOUN
brainmatters-818	104	15	frames	frame	NOUN
brainmatters-818	104	16	.	.	PUNCT
brainmatters-818	104	17	”	"	PUNCT
brainmatters-818	105	1	nature	nature	NOUN
brainmatters-818	105	2	biotechnology	biotechnology	NOUN
brainmatters-818	105	3	,	,	PUNCT
brainmatters-818	105	4	vol	vol	NOUN
brainmatters-818	105	5	.	.	PROPN
brainmatters-818	105	6	34	34	NUM
brainmatters-818	105	7	,	,	PUNCT
brainmatters-818	105	8	11	11	NUM
brainmatters-818	105	9	july	july	PROPN
brainmatters-818	105	10	2016	2016	NUM
brainmatters-818	105	11	,	,	PUNCT
brainmatters-818	105	12	pp	pp	ADV
brainmatters-818	105	13	.	.	PUNCT
brainmatters-818	106	1	875–880	875–880	NUM
brainmatters-818	106	2	.	.	NUM
brainmatters-818	106	3	,	,	PUNCT
brainmatters-818	106	4	doi	doi	PROPN
brainmatters-818	106	5	:	:	PUNCT
brainmatters-818	106	6	https://doi.org/10.1038	https://doi.org/10.1038	PROPN
brainmatters-818	106	7	/	/	SYM
brainmatters-818	106	8	nbt.3589	nbt.3589	PROPN
brainmatters-818	106	9	.	.	PUNCT
brainmatters-818	107	1	rinaldi	rinaldi	PROPN
brainmatters-818	107	2	,	,	PUNCT
brainmatters-818	107	3	c.	c.	PROPN
brainmatters-818	107	4	,	,	PUNCT
brainmatters-818	107	5	wood	wood	NOUN
brainmatters-818	107	6	,	,	PUNCT
brainmatters-818	107	7	m.	m.	NOUN
brainmatters-818	107	8	antisense	antisense	NOUN
brainmatters-818	107	9	oligonucleotides	oligonucleotide	VERB
brainmatters-818	107	10	:	:	PUNCT
brainmatters-818	107	11	the	the	DET
brainmatters-818	107	12	next	next	ADJ
brainmatters-818	107	13	frontier	frontier	NOUN
brainmatters-818	107	14	for	for	ADP
brainmatters-818	107	15	treatment	treatment	NOUN
brainmatters-818	107	16	of	of	ADP
brainmatters-818	107	17	neurological	neurological	ADJ
brainmatters-818	107	18	disorders	disorder	NOUN
brainmatters-818	107	19	.	.	PUNCT
brainmatters-818	108	1	nat	nat	PROPN
brainmatters-818	108	2	rev	rev	VERB
brainmatters-818	108	3	neurol	neurol	PROPN
brainmatters-818	108	4	14	14	NUM
brainmatters-818	108	5	,	,	PUNCT
brainmatters-818	108	6	9–21	9–21	PROPN
brainmatters-818	108	7	(	(	PUNCT
brainmatters-818	108	8	2018	2018	NUM
brainmatters-818	108	9	)	)	PUNCT
brainmatters-818	108	10	.	.	PUNCT
brainmatters-818	109	1	https://doi.org/10.1038/nrneurol.2017.148	https://doi.org/10.1038/nrneurol.2017.148	PROPN
brainmatters-818	109	2	stein	stein	PROPN
brainmatters-818	109	3	,	,	PUNCT
brainmatters-818	109	4	c	c	PROPN
brainmatters-818	109	5	a	a	PRON
brainmatters-818	109	6	,	,	PUNCT
brainmatters-818	109	7	and	and	CCONJ
brainmatters-818	109	8	y	y	PROPN
brainmatters-818	109	9	c	c	PROPN
brainmatters-818	109	10	cheng	cheng	PROPN
brainmatters-818	109	11	.	.	PUNCT
brainmatters-818	110	1	“	"	PUNCT
brainmatters-818	110	2	antisense	antisense	NOUN
brainmatters-818	110	3	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	110	4	as	as	ADP
brainmatters-818	110	5	therapeutic	therapeutic	ADJ
brainmatters-818	110	6	agents	agent	NOUN
brainmatters-818	110	7	--	--	PUNCT
brainmatters-818	110	8	is	be	AUX
brainmatters-818	110	9	the	the	DET
brainmatters-818	110	10	bullet	bullet	NOUN
brainmatters-818	110	11	really	really	ADV
brainmatters-818	110	12	magical	magical	ADJ
brainmatters-818	110	13	?	?	PUNCT
brainmatters-818	110	14	”	"	PUNCT
brainmatters-818	110	15	science	science	NOUN
brainmatters-818	110	16	,	,	PUNCT
brainmatters-818	110	17	vol	vol	NOUN
brainmatters-818	110	18	.	.	PROPN
brainmatters-818	110	19	261	261	NUM
brainmatters-818	110	20	,	,	PUNCT
brainmatters-818	110	21	no	no	INTJ
brainmatters-818	110	22	.	.	NOUN
brainmatters-818	110	23	5124	5124	NUM
brainmatters-818	110	24	,	,	PUNCT
brainmatters-818	110	25	20	20	NUM
brainmatters-818	110	26	aug	aug	PROPN
brainmatters-818	110	27	.	.	PROPN
brainmatters-818	110	28	1993	1993	NUM
brainmatters-818	110	29	,	,	PUNCT
brainmatters-818	110	30	pp	pp	ADJ
brainmatters-818	110	31	.	.	PUNCT
brainmatters-818	111	1	1004–1012	1004–1012	NUM
brainmatters-818	111	2	.	.	PUNCT
brainmatters-818	112	1	,	,	PUNCT
brainmatters-818	112	2	doi	doi	PROPN
brainmatters-818	112	3	:	:	PUNCT
brainmatters-818	112	4	science.8351515	science.8351515	PROPN
brainmatters-818	112	5	.	.	PROPN
brainmatters-818	112	6	smith	smith	PROPN
brainmatters-818	112	7	,	,	PUNCT
brainmatters-818	112	8	r.	r.	PROPN
brainmatters-818	112	9	a.	a.	NOUN
brainmatters-818	112	10	“	"	PUNCT
brainmatters-818	112	11	antisense	antisense	NOUN
brainmatters-818	112	12	oligonucleotide	oligonucleotide	NOUN
brainmatters-818	112	13	therapy	therapy	NOUN
brainmatters-818	112	14	for	for	ADP
brainmatters-818	112	15	neurodegenerative	neurodegenerative	ADJ
brainmatters-818	112	16	disease	disease	NOUN
brainmatters-818	112	17	.	.	PUNCT
brainmatters-818	112	18	”	"	PUNCT
brainmatters-818	113	1	journal	journal	NOUN
brainmatters-818	113	2	of	of	ADP
brainmatters-818	113	3	clinical	clinical	ADJ
brainmatters-818	113	4	investigation	investigation	NOUN
brainmatters-818	113	5	,	,	PUNCT
brainmatters-818	113	6	vol	vol	NOUN
brainmatters-818	113	7	.	.	PROPN
brainmatters-818	113	8	116	116	NUM
brainmatters-818	113	9	,	,	PUNCT
brainmatters-818	113	10	no	no	INTJ
brainmatters-818	113	11	.	.	NOUN
brainmatters-818	113	12	8	8	NUM
brainmatters-818	113	13	,	,	PUNCT
brainmatters-818	113	14	2006	2006	NUM
brainmatters-818	113	15	,	,	PUNCT
brainmatters-818	113	16	pp	pp	ADV
brainmatters-818	113	17	.	.	PUNCT
brainmatters-818	114	1	2290–2296	2290–2296	X
brainmatters-818	114	2	.	.	PUNCT
brainmatters-818	114	3	,	,	PUNCT
brainmatters-818	114	4	doi:10.1172	doi:10.1172	NOUN
brainmatters-818	114	5	/	/	SYM
brainmatters-818	114	6	jci25424	jci25424	PROPN
brainmatters-818	114	7	.	.	PUNCT
brainmatters-818	115	1	uhlmann	uhlmann	PROPN
brainmatters-818	115	2	,	,	PUNCT
brainmatters-818	115	3	eugen	eugen	PROPN
brainmatters-818	115	4	,	,	PUNCT
brainmatters-818	115	5	and	and	CCONJ
brainmatters-818	115	6	anusch	anusch	VERB
brainmatters-818	115	7	peyman	peyman	NOUN
brainmatters-818	115	8	.	.	PUNCT
brainmatters-818	116	1	“	"	PUNCT
brainmatters-818	116	2	antisense	antisense	NOUN
brainmatters-818	116	3	oligonucleotides	oligonucleotide	VERB
brainmatters-818	116	4	:	:	PUNCT
brainmatters-818	116	5	a	a	DET
brainmatters-818	116	6	new	new	ADJ
brainmatters-818	116	7	therapeutic	therapeutic	ADJ
brainmatters-818	116	8	principle	principle	NOUN
brainmatters-818	116	9	.	.	PUNCT
brainmatters-818	116	10	”	"	PUNCT
brainmatters-818	117	1	chemical	chemical	ADJ
brainmatters-818	117	2	reviews	review	NOUN
brainmatters-818	117	3	,	,	PUNCT
brainmatters-818	117	4	vol	vol	NOUN
brainmatters-818	117	5	.	.	PROPN
brainmatters-818	117	6	90	90	NUM
brainmatters-818	117	7	,	,	PUNCT
brainmatters-818	117	8	no	no	INTJ
brainmatters-818	117	9	.	.	NOUN
brainmatters-818	117	10	4	4	NUM
brainmatters-818	117	11	,	,	PUNCT
brainmatters-818	117	12	1990	1990	NUM
brainmatters-818	117	13	,	,	PUNCT
brainmatters-818	117	14	pp	pp	ADJ
brainmatters-818	117	15	.	.	PUNCT
brainmatters-818	118	1	543–584	543–584	NUM
brainmatters-818	118	2	.	.	NUM
brainmatters-818	118	3	,	,	PUNCT
brainmatters-818	118	4	doi:10.1021	doi:10.1021	ADJ
brainmatters-818	118	5	/	/	SYM
brainmatters-818	118	6	cr00102a001	cr00102a001	NOUN
brainmatters-818	118	7	.	.	PUNCT
brainmatters-818	119	1	wurster	wurster	PROPN
brainmatters-818	119	2	,	,	PUNCT
brainmatters-818	119	3	claudia	claudia	NOUN
brainmatters-818	119	4	d	d	PROPN
brainmatters-818	119	5	,	,	PUNCT
brainmatters-818	119	6	and	and	CCONJ
brainmatters-818	119	7	albert	albert	PROPN
brainmatters-818	119	8	c	c	AUX
brainmatters-818	119	9	ludolph	ludolph	VERB
brainmatters-818	119	10	.	.	PUNCT
brainmatters-818	120	1	“	"	PUNCT
brainmatters-818	120	2	antisense	antisense	NOUN
brainmatters-818	120	3	oligonucleotides	oligonucleotide	NOUN
brainmatters-818	120	4	in	in	ADP
brainmatters-818	120	5	neurological	neurological	ADJ
brainmatters-818	120	6	disorders	disorder	NOUN
brainmatters-818	120	7	.	.	PUNCT
brainmatters-818	120	8	”	"	PUNCT
brainmatters-818	121	1	therapeutic	therapeutic	ADJ
brainmatters-818	121	2	advances	advance	NOUN
brainmatters-818	121	3	in	in	ADP
brainmatters-818	121	4	neurological	neurological	ADJ
brainmatters-818	121	5	disorders	disorder	NOUN
brainmatters-818	121	6	vol	vol	NOUN
brainmatters-818	121	7	.	.	PUNCT
brainmatters-818	121	8	11	11	NUM
brainmatters-818	121	9	1756286418776932	1756286418776932	NUM
brainmatters-818	121	10	.	.	PUNCT
brainmatters-818	122	1	23	23	NUM
brainmatters-818	122	2	may	may	NOUN
brainmatters-818	122	3	.	.	PUNCT
brainmatters-818	123	1	2018	2018	NUM
brainmatters-818	123	2	,	,	PUNCT
brainmatters-818	123	3	doi:10.1177/1756286418776932	doi:10.1177/1756286418776932	VERB
brainmatters-818	123	4	13	13	NUM
brainmatters-818	123	5	https://doi.org/10.1038/nbt.3589	https://doi.org/10.1038/nbt.3589	NOUN