id	sid	tid	token	lemma	pos
brainmatters-880	1	1	copy	copy	NOUN
brainmatters-880	1	2	of	of	ADP
brainmatters-880	1	3	volume	volume	NOUN
brainmatters-880	1	4	6	6	NUM
brainmatters-880	1	5	publication	publication	NOUN
brainmatters-880	1	6	implications	implication	NOUN
brainmatters-880	1	7	of	of	ADP
brainmatters-880	1	8	gpcrs	gpcrs	PROPN
brainmatters-880	1	9	in	in	ADP
brainmatters-880	1	10	alzheimer	alzheimer	PROPN
brainmatters-880	1	11	’s	’s	PART
brainmatters-880	1	12	katilyn	katilyn	ADJ
brainmatters-880	1	13	simmons	simmon	NOUN
brainmatters-880	1	14	abstract	abstract	ADJ
brainmatters-880	1	15	g	g	NOUN
brainmatters-880	1	16	-	-	PUNCT
brainmatters-880	1	17	protein	protein	NOUN
brainmatters-880	1	18	coupled	couple	VERB
brainmatters-880	1	19	receptors	receptor	NOUN
brainmatters-880	1	20	,	,	PUNCT
brainmatters-880	1	21	or	or	CCONJ
brainmatters-880	1	22	gpcrs	gpcrs	PROPN
brainmatters-880	1	23	,	,	PUNCT
brainmatters-880	1	24	are	be	AUX
brainmatters-880	1	25	a	a	DET
brainmatters-880	1	26	large	large	ADJ
brainmatters-880	1	27	,	,	PUNCT
brainmatters-880	1	28	diverse	diverse	ADJ
brainmatters-880	1	29	group	group	NOUN
brainmatters-880	1	30	of	of	ADP
brainmatters-880	1	31	receptors	receptor	NOUN
brainmatters-880	1	32	found	find	VERB
brainmatters-880	1	33	in	in	ADP
brainmatters-880	1	34	all	all	DET
brainmatters-880	1	35	eukaryotes	eukaryote	NOUN
brainmatters-880	1	36	.	.	PUNCT
brainmatters-880	2	1	gpcrs	gpcrs	PROPN
brainmatters-880	2	2	,	,	PUNCT
brainmatters-880	2	3	as	as	SCONJ
brainmatters-880	2	4	their	their	PRON
brainmatters-880	2	5	name	name	NOUN
brainmatters-880	2	6	suggests	suggest	VERB
brainmatters-880	2	7	,	,	PUNCT
brainmatters-880	2	8	interact	interact	VERB
brainmatters-880	2	9	with	with	ADP
brainmatters-880	2	10	g	g	NOUN
brainmatters-880	2	11	-	-	PUNCT
brainmatters-880	2	12	proteins	protein	NOUN
brainmatters-880	2	13	in	in	ADP
brainmatters-880	2	14	the	the	DET
brainmatters-880	2	15	cell	cell	NOUN
brainmatters-880	2	16	in	in	ADP
brainmatters-880	2	17	order	order	NOUN
brainmatters-880	2	18	to	to	PART
brainmatters-880	2	19	carry	carry	VERB
brainmatters-880	2	20	out	out	ADP
brainmatters-880	2	21	a	a	DET
brainmatters-880	2	22	variety	variety	NOUN
brainmatters-880	2	23	of	of	ADP
brainmatters-880	2	24	cellular	cellular	ADJ
brainmatters-880	2	25	responses	response	NOUN
brainmatters-880	2	26	.	.	PUNCT
brainmatters-880	3	1	most	most	ADJ
brainmatters-880	3	2	of	of	ADP
brainmatters-880	3	3	these	these	DET
brainmatters-880	3	4	cellular	cellular	ADJ
brainmatters-880	3	5	responses	response	NOUN
brainmatters-880	3	6	are	be	AUX
brainmatters-880	3	7	related	relate	VERB
brainmatters-880	3	8	to	to	ADP
brainmatters-880	3	9	sensory	sensory	ADJ
brainmatters-880	3	10	functions	function	NOUN
brainmatters-880	3	11	such	such	ADJ
brainmatters-880	3	12	as	as	ADP
brainmatters-880	3	13	pheromone	pheromone	NOUN
brainmatters-880	3	14	signaling	signaling	NOUN
brainmatters-880	3	15	,	,	PUNCT
brainmatters-880	3	16	taste	taste	NOUN
brainmatters-880	3	17	,	,	PUNCT
brainmatters-880	3	18	light	light	ADJ
brainmatters-880	3	19	perception	perception	NOUN
brainmatters-880	3	20	,	,	PUNCT
brainmatters-880	3	21	and	and	CCONJ
brainmatters-880	3	22	other	other	ADJ
brainmatters-880	3	23	processes	process	NOUN
brainmatters-880	3	24	in	in	ADP
brainmatters-880	3	25	the	the	DET
brainmatters-880	3	26	brain	brain	NOUN
brainmatters-880	3	27	(	(	PUNCT
brainmatters-880	3	28	azam	azam	PROPN
brainmatters-880	3	29	et	et	PROPN
brainmatters-880	3	30	al	al	PROPN
brainmatters-880	3	31	.	.	PROPN
brainmatters-880	3	32	,	,	PUNCT
brainmatters-880	3	33	2020	2020	NUM
brainmatters-880	3	34	)	)	PUNCT
brainmatters-880	3	35	.	.	PUNCT
brainmatters-880	4	1	for	for	ADP
brainmatters-880	4	2	this	this	DET
brainmatters-880	4	3	reason	reason	NOUN
brainmatters-880	4	4	,	,	PUNCT
brainmatters-880	4	5	gpcrs	gpcrs	PROPN
brainmatters-880	4	6	are	be	AUX
brainmatters-880	4	7	a	a	DET
brainmatters-880	4	8	very	very	ADV
brainmatters-880	4	9	promising	promising	ADJ
brainmatters-880	4	10	target	target	NOUN
brainmatters-880	4	11	for	for	ADP
brainmatters-880	4	12	drugs	drug	NOUN
brainmatters-880	4	13	that	that	PRON
brainmatters-880	4	14	treat	treat	VERB
brainmatters-880	4	15	disorders	disorder	NOUN
brainmatters-880	4	16	affecting	affect	VERB
brainmatters-880	4	17	these	these	DET
brainmatters-880	4	18	processes	process	NOUN
brainmatters-880	4	19	.	.	PUNCT
brainmatters-880	5	1	these	these	DET
brainmatters-880	5	2	disorders	disorder	NOUN
brainmatters-880	5	3	include	include	VERB
brainmatters-880	5	4	many	many	ADJ
brainmatters-880	5	5	neurodegenerative	neurodegenerative	ADJ
brainmatters-880	5	6	cns	cns	NOUN
brainmatters-880	5	7	disorders	disorder	NOUN
brainmatters-880	5	8	,	,	PUNCT
brainmatters-880	5	9	such	such	ADJ
brainmatters-880	5	10	as	as	ADP
brainmatters-880	5	11	alzheimer	alzheimer	PROPN
brainmatters-880	5	12	’s	’s	PART
brainmatters-880	5	13	disease	disease	NOUN
brainmatters-880	5	14	.	.	PUNCT
brainmatters-880	6	1	while	while	SCONJ
brainmatters-880	6	2	many	many	ADJ
brainmatters-880	6	3	current	current	ADJ
brainmatters-880	6	4	drugs	drug	NOUN
brainmatters-880	6	5	and	and	CCONJ
brainmatters-880	6	6	therapies	therapy	NOUN
brainmatters-880	6	7	treat	treat	VERB
brainmatters-880	6	8	symptoms	symptom	NOUN
brainmatters-880	6	9	of	of	ADP
brainmatters-880	6	10	these	these	DET
brainmatters-880	6	11	disorders	disorder	NOUN
brainmatters-880	6	12	,	,	PUNCT
brainmatters-880	6	13	drugs	drug	NOUN
brainmatters-880	6	14	that	that	PRON
brainmatters-880	6	15	target	target	VERB
brainmatters-880	6	16	gpcrs	gpcr	NOUN
brainmatters-880	6	17	more	more	ADV
brainmatters-880	6	18	directly	directly	ADV
brainmatters-880	6	19	would	would	AUX
brainmatters-880	6	20	focus	focus	VERB
brainmatters-880	6	21	on	on	ADP
brainmatters-880	6	22	the	the	DET
brainmatters-880	6	23	cause	cause	NOUN
brainmatters-880	6	24	of	of	ADP
brainmatters-880	6	25	the	the	DET
brainmatters-880	6	26	disorders	disorder	NOUN
brainmatters-880	6	27	at	at	ADP
brainmatters-880	6	28	their	their	PRON
brainmatters-880	6	29	roots	root	NOUN
brainmatters-880	6	30	(	(	PUNCT
brainmatters-880	6	31	huang	huang	PROPN
brainmatters-880	6	32	et	et	PROPN
brainmatters-880	6	33	al	al	PROPN
brainmatters-880	6	34	.	.	PROPN
brainmatters-880	6	35	,	,	PUNCT
brainmatters-880	6	36	2017	2017	NUM
brainmatters-880	6	37	)	)	PUNCT
brainmatters-880	6	38	.	.	PUNCT
brainmatters-880	7	1	insight	insight	NOUN
brainmatters-880	7	2	into	into	ADP
brainmatters-880	7	3	the	the	DET
brainmatters-880	7	4	mechanisms	mechanism	NOUN
brainmatters-880	7	5	involved	involve	VERB
brainmatters-880	7	6	in	in	ADP
brainmatters-880	7	7	signal	signal	ADJ
brainmatters-880	7	8	transduction	transduction	NOUN
brainmatters-880	7	9	pathways	pathway	NOUN
brainmatters-880	7	10	in	in	ADP
brainmatters-880	7	11	disorders	disorder	NOUN
brainmatters-880	7	12	such	such	ADJ
brainmatters-880	7	13	as	as	ADP
brainmatters-880	7	14	those	those	PRON
brainmatters-880	7	15	in	in	ADP
brainmatters-880	7	16	alzheimer	alzheimer	PROPN
brainmatters-880	7	17	’s	’s	PART
brainmatters-880	7	18	would	would	AUX
brainmatters-880	7	19	lead	lead	VERB
brainmatters-880	7	20	us	we	PRON
brainmatters-880	7	21	to	to	ADP
brainmatters-880	7	22	new	new	ADJ
brainmatters-880	7	23	discoveries	discovery	NOUN
brainmatters-880	7	24	that	that	PRON
brainmatters-880	7	25	could	could	AUX
brainmatters-880	7	26	alter	alter	VERB
brainmatters-880	7	27	the	the	DET
brainmatters-880	7	28	course	course	NOUN
brainmatters-880	7	29	of	of	ADP
brainmatters-880	7	30	these	these	PRON
brainmatters-880	7	31	and	and	CCONJ
brainmatters-880	7	32	many	many	ADJ
brainmatters-880	7	33	other	other	ADJ
brainmatters-880	7	34	disorders	disorder	NOUN
brainmatters-880	7	35	of	of	ADP
brainmatters-880	7	36	the	the	DET
brainmatters-880	7	37	cns	cns	NOUN
brainmatters-880	7	38	.	.	PUNCT
brainmatters-880	8	1	why	why	SCONJ
brainmatters-880	8	2	are	be	AUX
brainmatters-880	8	3	receptors	receptor	NOUN
brainmatters-880	8	4	important	important	ADJ
brainmatters-880	8	5	?	?	PUNCT
brainmatters-880	9	1	the	the	DET
brainmatters-880	9	2	neurons	neuron	NOUN
brainmatters-880	9	3	in	in	ADP
brainmatters-880	9	4	your	your	PRON
brainmatters-880	9	5	brain	brain	NOUN
brainmatters-880	9	6	,	,	PUNCT
brainmatters-880	9	7	as	as	ADV
brainmatters-880	9	8	well	well	ADV
brainmatters-880	9	9	as	as	ADP
brainmatters-880	9	10	other	other	ADJ
brainmatters-880	9	11	cells	cell	NOUN
brainmatters-880	9	12	in	in	ADP
brainmatters-880	9	13	your	your	PRON
brainmatters-880	9	14	body	body	NOUN
brainmatters-880	9	15	,	,	PUNCT
brainmatters-880	9	16	are	be	AUX
brainmatters-880	9	17	constantly	constantly	ADV
brainmatters-880	9	18	sending	send	VERB
brainmatters-880	9	19	signals	signal	NOUN
brainmatters-880	9	20	in	in	ADP
brainmatters-880	9	21	all	all	DET
brainmatters-880	9	22	directions	direction	NOUN
brainmatters-880	9	23	to	to	ADP
brainmatters-880	9	24	any	any	DET
brainmatters-880	9	25	neuron	neuron	NOUN
brainmatters-880	9	26	that	that	PRON
brainmatters-880	9	27	will	will	AUX
brainmatters-880	9	28	listen	listen	VERB
brainmatters-880	9	29	and	and	CCONJ
brainmatters-880	9	30	respond	respond	VERB
brainmatters-880	9	31	.	.	PUNCT
brainmatters-880	10	1	these	these	DET
brainmatters-880	10	2	neighboring	neighboring	NOUN
brainmatters-880	10	3	cells	cell	NOUN
brainmatters-880	10	4	need	need	VERB
brainmatters-880	10	5	a	a	DET
brainmatters-880	10	6	way	way	NOUN
brainmatters-880	10	7	to	to	PART
brainmatters-880	10	8	“	"	PUNCT
brainmatters-880	10	9	listen	listen	VERB
brainmatters-880	10	10	”	"	PUNCT
brainmatters-880	10	11	to	to	ADP
brainmatters-880	10	12	these	these	DET
brainmatters-880	10	13	communications	communication	NOUN
brainmatters-880	10	14	and	and	CCONJ
brainmatters-880	10	15	interpret	interpret	VERB
brainmatters-880	10	16	them	they	PRON
brainmatters-880	10	17	in	in	ADP
brainmatters-880	10	18	meaningful	meaningful	ADJ
brainmatters-880	10	19	ways	way	NOUN
brainmatters-880	10	20	so	so	SCONJ
brainmatters-880	10	21	that	that	SCONJ
brainmatters-880	10	22	the	the	DET
brainmatters-880	10	23	cell	cell	NOUN
brainmatters-880	10	24	can	can	AUX
brainmatters-880	10	25	respond	respond	VERB
brainmatters-880	10	26	accordingly	accordingly	ADV
brainmatters-880	10	27	.	.	PUNCT
brainmatters-880	11	1	an	an	DET
brainmatters-880	11	2	example	example	NOUN
brainmatters-880	11	3	of	of	ADP
brainmatters-880	11	4	one	one	NUM
brainmatters-880	11	5	way	way	NOUN
brainmatters-880	11	6	that	that	PRON
brainmatters-880	11	7	the	the	DET
brainmatters-880	11	8	cell	cell	NOUN
brainmatters-880	11	9	does	do	VERB
brainmatters-880	11	10	this	this	PRON
brainmatters-880	11	11	is	be	AUX
brainmatters-880	11	12	through	through	ADP
brainmatters-880	11	13	receptors	receptor	NOUN
brainmatters-880	11	14	.	.	PUNCT
brainmatters-880	12	1	when	when	SCONJ
brainmatters-880	12	2	a	a	DET
brainmatters-880	12	3	cell	cell	NOUN
brainmatters-880	12	4	fires	fire	NOUN
brainmatters-880	12	5	,	,	PUNCT
brainmatters-880	12	6	it	it	PRON
brainmatters-880	12	7	releases	release	VERB
brainmatters-880	12	8	a	a	DET
brainmatters-880	12	9	signaling	signal	VERB
brainmatters-880	12	10	molecule	molecule	NOUN
brainmatters-880	12	11	–	–	PUNCT
brainmatters-880	12	12	typically	typically	ADV
brainmatters-880	12	13	a	a	DET
brainmatters-880	12	14	hormone	hormone	NOUN
brainmatters-880	12	15	or	or	CCONJ
brainmatters-880	12	16	a	a	DET
brainmatters-880	12	17	neurotransmitter	neurotransmitter	NOUN
brainmatters-880	12	18	–	–	PUNCT
brainmatters-880	12	19	called	call	VERB
brainmatters-880	12	20	a	a	DET
brainmatters-880	12	21	ligand	ligand	NOUN
brainmatters-880	12	22	,	,	PUNCT
brainmatters-880	12	23	which	which	PRON
brainmatters-880	12	24	then	then	ADV
brainmatters-880	12	25	binds	bind	VERB
brainmatters-880	12	26	to	to	ADP
brainmatters-880	12	27	the	the	DET
brainmatters-880	12	28	receptor	receptor	NOUN
brainmatters-880	12	29	.	.	PUNCT
brainmatters-880	13	1	while	while	SCONJ
brainmatters-880	13	2	some	some	DET
brainmatters-880	13	3	signals	signal	NOUN
brainmatters-880	13	4	do	do	AUX
brainmatters-880	13	5	result	result	VERB
brainmatters-880	13	6	in	in	ADP
brainmatters-880	13	7	direct	direct	ADJ
brainmatters-880	13	8	cellular	cellular	ADJ
brainmatters-880	13	9	responses	response	NOUN
brainmatters-880	13	10	,	,	PUNCT
brainmatters-880	13	11	such	such	ADJ
brainmatters-880	13	12	as	as	ADP
brainmatters-880	13	13	in	in	ADP
brainmatters-880	13	14	the	the	DET
brainmatters-880	13	15	case	case	NOUN
brainmatters-880	13	16	of	of	ADP
brainmatters-880	13	17	a	a	DET
brainmatters-880	13	18	ligand	ligand	NOUN
brainmatters-880	13	19	binding	bind	VERB
brainmatters-880	13	20	to	to	ADP
brainmatters-880	13	21	an	an	DET
brainmatters-880	13	22	intracellular	intracellular	ADJ
brainmatters-880	13	23	receptor	receptor	NOUN
brainmatters-880	13	24	,	,	PUNCT
brainmatters-880	13	25	signals	signal	NOUN
brainmatters-880	13	26	usually	usually	ADV
brainmatters-880	13	27	initiate	initiate	VERB
brainmatters-880	13	28	some	some	DET
brainmatters-880	13	29	type	type	NOUN
brainmatters-880	13	30	of	of	ADP
brainmatters-880	13	31	cellular	cellular	ADJ
brainmatters-880	13	32	response	response	NOUN
brainmatters-880	13	33	through	through	ADP
brainmatters-880	13	34	a	a	DET
brainmatters-880	13	35	series	series	NOUN
brainmatters-880	13	36	of	of	ADP
brainmatters-880	13	37	steps	step	NOUN
brainmatters-880	13	38	called	call	VERB
brainmatters-880	13	39	a	a	DET
brainmatters-880	13	40	signal	signal	ADJ
brainmatters-880	13	41	transduction	transduction	NOUN
brainmatters-880	13	42	pathway	pathway	NOUN
brainmatters-880	13	43	(	(	PUNCT
brainmatters-880	13	44	brooker	brooker	PROPN
brainmatters-880	13	45	et	et	PROPN
brainmatters-880	13	46	al	al	PROPN
brainmatters-880	13	47	.	.	PROPN
brainmatters-880	13	48	,	,	PUNCT
brainmatters-880	13	49	2022	2022	NUM
brainmatters-880	13	50	)	)	PUNCT
brainmatters-880	13	51	.	.	PUNCT
brainmatters-880	14	1	this	this	DET
brainmatters-880	14	2	pathway	pathway	NOUN
brainmatters-880	14	3	consists	consist	VERB
brainmatters-880	14	4	of	of	ADP
brainmatters-880	14	5	a	a	DET
brainmatters-880	14	6	series	series	NOUN
brainmatters-880	14	7	of	of	ADP
brainmatters-880	14	8	changes	change	NOUN
brainmatters-880	14	9	that	that	PRON
brainmatters-880	14	10	lead	lead	VERB
brainmatters-880	14	11	to	to	ADP
brainmatters-880	14	12	the	the	DET
brainmatters-880	14	13	production	production	NOUN
brainmatters-880	14	14	of	of	ADP
brainmatters-880	14	15	a	a	DET
brainmatters-880	14	16	secondary	secondary	ADJ
brainmatters-880	14	17	signaling	signal	VERB
brainmatters-880	14	18	molecule	molecule	NOUN
brainmatters-880	14	19	which	which	PRON
brainmatters-880	14	20	can	can	AUX
brainmatters-880	14	21	lead	lead	VERB
brainmatters-880	14	22	to	to	ADP
brainmatters-880	14	23	various	various	ADJ
brainmatters-880	14	24	cellular	cellular	ADJ
brainmatters-880	14	25	responses	response	NOUN
brainmatters-880	14	26	,	,	PUNCT
brainmatters-880	14	27	such	such	ADJ
brainmatters-880	14	28	as	as	ADP
brainmatters-880	14	29	altering	alter	VERB
brainmatters-880	14	30	enzymatic	enzymatic	ADJ
brainmatters-880	14	31	activity	activity	NOUN
brainmatters-880	14	32	,	,	PUNCT
brainmatters-880	14	33	altering	alter	VERB
brainmatters-880	14	34	protein	protein	NOUN
brainmatters-880	14	35	function	function	NOUN
brainmatters-880	14	36	,	,	PUNCT
brainmatters-880	14	37	or	or	CCONJ
brainmatters-880	14	38	altering	alter	VERB
brainmatters-880	14	39	the	the	DET
brainmatters-880	14	40	function	function	NOUN
brainmatters-880	14	41	of	of	ADP
brainmatters-880	14	42	transcription	transcription	NOUN
brainmatters-880	14	43	factors	factor	NOUN
brainmatters-880	14	44	which	which	PRON
brainmatters-880	14	45	activate	activate	VERB
brainmatters-880	14	46	gene	gene	NOUN
brainmatters-880	14	47	expression	expression	NOUN
brainmatters-880	14	48	–	–	PUNCT
brainmatters-880	14	49	essentially	essentially	ADV
brainmatters-880	14	50	turning	turn	VERB
brainmatters-880	14	51	a	a	DET
brainmatters-880	14	52	gene	gene	NOUN
brainmatters-880	14	53	on	on	ADP
brainmatters-880	14	54	or	or	CCONJ
brainmatters-880	14	55	off	off	ADV
brainmatters-880	14	56	.	.	PUNCT
brainmatters-880	15	1	the	the	DET
brainmatters-880	15	2	proper	proper	ADJ
brainmatters-880	15	3	functioning	functioning	NOUN
brainmatters-880	15	4	of	of	ADP
brainmatters-880	15	5	any	any	DET
brainmatters-880	15	6	receptor	receptor	NOUN
brainmatters-880	15	7	is	be	AUX
brainmatters-880	15	8	vital	vital	ADJ
brainmatters-880	15	9	to	to	ADP
brainmatters-880	15	10	the	the	DET
brainmatters-880	15	11	normal	normal	ADJ
brainmatters-880	15	12	everyday	everyday	ADJ
brainmatters-880	15	13	bodily	bodily	ADJ
brainmatters-880	15	14	processes	process	NOUN
brainmatters-880	15	15	that	that	PRON
brainmatters-880	15	16	are	be	AUX
brainmatters-880	15	17	happening	happen	VERB
brainmatters-880	15	18	constantly	constantly	ADV
brainmatters-880	15	19	in	in	ADP
brainmatters-880	15	20	your	your	PRON
brainmatters-880	15	21	body	body	NOUN
brainmatters-880	15	22	.	.	PUNCT
brainmatters-880	16	1	what	what	PRON
brainmatters-880	16	2	are	be	AUX
brainmatters-880	16	3	gpcrs	gpcrs	NOUN
brainmatters-880	16	4	?	?	PUNCT
brainmatters-880	17	1	one	one	NUM
brainmatters-880	17	2	especially	especially	ADV
brainmatters-880	17	3	important	important	ADJ
brainmatters-880	17	4	group	group	NOUN
brainmatters-880	17	5	of	of	ADP
brainmatters-880	17	6	receptors	receptor	NOUN
brainmatters-880	17	7	that	that	PRON
brainmatters-880	17	8	are	be	AUX
brainmatters-880	17	9	specifically	specifically	ADV
brainmatters-880	17	10	relevant	relevant	ADJ
brainmatters-880	17	11	in	in	ADP
brainmatters-880	17	12	the	the	DET
brainmatters-880	17	13	neuropathology	neuropathology	NOUN
brainmatters-880	17	14	realm	realm	NOUN
brainmatters-880	17	15	are	be	AUX
brainmatters-880	17	16	gpcrs	gpcrs	NOUN
brainmatters-880	17	17	,	,	PUNCT
brainmatters-880	17	18	or	or	CCONJ
brainmatters-880	17	19	g	g	NOUN
brainmatters-880	17	20	-	-	PUNCT
brainmatters-880	17	21	protein	protein	NOUN
brainmatters-880	17	22	coupled	couple	VERB
brainmatters-880	17	23	receptors	receptor	NOUN
brainmatters-880	17	24	.	.	PUNCT
brainmatters-880	18	1	to	to	PART
brainmatters-880	18	2	put	put	VERB
brainmatters-880	18	3	things	thing	NOUN
brainmatters-880	18	4	into	into	ADP
brainmatters-880	18	5	scope	scope	NOUN
brainmatters-880	18	6	,	,	PUNCT
brainmatters-880	18	7	there	there	PRON
brainmatters-880	18	8	are	be	VERB
brainmatters-880	18	9	over	over	ADP
brainmatters-880	18	10	370	370	NUM
brainmatters-880	18	11	non	non	ADJ
brainmatters-880	18	12	-	-	ADJ
brainmatters-880	18	13	sensory	sensory	ADJ
brainmatters-880	18	14	gpcrs	gpcrs	NOUN
brainmatters-880	18	15	currently	currently	ADV
brainmatters-880	18	16	identified	identify	VERB
brainmatters-880	18	17	,	,	PUNCT
brainmatters-880	18	18	and	and	CCONJ
brainmatters-880	18	19	90	90	NUM
brainmatters-880	18	20	%	%	NOUN
brainmatters-880	18	21	of	of	ADP
brainmatters-880	18	22	those	those	DET
brainmatters-880	18	23	370	370	NUM
brainmatters-880	18	24	receptors	receptor	NOUN
brainmatters-880	18	25	are	be	AUX
brainmatters-880	18	26	expressed	express	VERB
brainmatters-880	18	27	in	in	ADP
brainmatters-880	18	28	the	the	DET
brainmatters-880	18	29	brain	brain	NOUN
brainmatters-880	18	30	(	(	PUNCT
brainmatters-880	18	31	azam	azam	PROPN
brainmatters-880	18	32	et	et	PROPN
brainmatters-880	18	33	al	al	PROPN
brainmatters-880	18	34	.	.	PROPN
brainmatters-880	18	35	,	,	PUNCT
brainmatters-880	18	36	2020	2020	NUM
brainmatters-880	18	37	)	)	PUNCT
brainmatters-880	18	38	.	.	PUNCT
brainmatters-880	19	1	gpcrs	gpcrs	PROPN
brainmatters-880	19	2	are	be	AUX
brainmatters-880	19	3	a	a	DET
brainmatters-880	19	4	remarkably	remarkably	ADV
brainmatters-880	19	5	diverse	diverse	ADJ
brainmatters-880	19	6	group	group	NOUN
brainmatters-880	19	7	of	of	ADP
brainmatters-880	19	8	receptors	receptor	NOUN
brainmatters-880	19	9	that	that	PRON
brainmatters-880	19	10	bind	bind	VERB
brainmatters-880	19	11	a	a	DET
brainmatters-880	19	12	vast	vast	ADJ
brainmatters-880	19	13	variety	variety	NOUN
brainmatters-880	19	14	of	of	ADP
brainmatters-880	19	15	different	different	ADJ
brainmatters-880	19	16	signaling	signal	VERB
brainmatters-880	19	17	molecules	molecule	NOUN
brainmatters-880	19	18	,	,	PUNCT
brainmatters-880	19	19	and	and	CCONJ
brainmatters-880	19	20	therefore	therefore	ADV
brainmatters-880	19	21	perform	perform	VERB
brainmatters-880	19	22	a	a	DET
brainmatters-880	19	23	variety	variety	NOUN
brainmatters-880	19	24	of	of	ADP
brainmatters-880	19	25	difference	difference	NOUN
brainmatters-880	19	26	functions	function	NOUN
brainmatters-880	19	27	in	in	ADP
brainmatters-880	19	28	your	your	PRON
brainmatters-880	19	29	body	body	NOUN
brainmatters-880	19	30	and	and	CCONJ
brainmatters-880	19	31	brain	brain	NOUN
brainmatters-880	19	32	.	.	PUNCT
brainmatters-880	20	1	in	in	ADP
brainmatters-880	20	2	the	the	DET
brainmatters-880	20	3	brain	brain	NOUN
brainmatters-880	20	4	,	,	PUNCT
brainmatters-880	20	5	they	they	PRON
brainmatters-880	20	6	are	be	AUX
brainmatters-880	20	7	responsible	responsible	ADJ
brainmatters-880	20	8	for	for	ADP
brainmatters-880	20	9	things	thing	NOUN
brainmatters-880	20	10	like	like	ADP
brainmatters-880	20	11	taste	taste	NOUN
brainmatters-880	20	12	and	and	CCONJ
brainmatters-880	20	13	appetite	appetite	NOUN
brainmatters-880	20	14	,	,	PUNCT
brainmatters-880	20	15	pheromone	pheromone	NOUN
brainmatters-880	20	16	signaling	signaling	NOUN
brainmatters-880	20	17	and	and	CCONJ
brainmatters-880	20	18	mood	mood	NOUN
brainmatters-880	20	19	,	,	PUNCT
brainmatters-880	20	20	vision	vision	NOUN
brainmatters-880	20	21	and	and	CCONJ
brainmatters-880	20	22	light	light	ADJ
brainmatters-880	20	23	perception	perception	NOUN
brainmatters-880	20	24	,	,	PUNCT
brainmatters-880	20	25	immune	immune	ADJ
brainmatters-880	20	26	regulation	regulation	NOUN
brainmatters-880	20	27	,	,	PUNCT
brainmatters-880	20	28	and	and	CCONJ
brainmatters-880	20	29	more	more	ADJ
brainmatters-880	20	30	general	general	ADJ
brainmatters-880	20	31	functions	function	NOUN
brainmatters-880	20	32	like	like	ADP
brainmatters-880	20	33	cognition	cognition	NOUN
brainmatters-880	20	34	and	and	CCONJ
brainmatters-880	20	35	synaptic	synaptic	ADJ
brainmatters-880	20	36	transmission	transmission	NOUN
brainmatters-880	20	37	(	(	PUNCT
brainmatters-880	20	38	huang	huang	PROPN
brainmatters-880	20	39	et	et	PROPN
brainmatters-880	20	40	al	al	PROPN
brainmatters-880	20	41	.	.	PROPN
brainmatters-880	20	42	,	,	PUNCT
brainmatters-880	20	43	2017	2017	NUM
brainmatters-880	20	44	)	)	PUNCT
brainmatters-880	20	45	.	.	PUNCT
brainmatters-880	21	1	it	it	PRON
brainmatters-880	21	2	is	be	AUX
brainmatters-880	21	3	for	for	ADP
brainmatters-880	21	4	this	this	DET
brainmatters-880	21	5	reason	reason	NOUN
brainmatters-880	21	6	that	that	SCONJ
brainmatters-880	21	7	regulation	regulation	NOUN
brainmatters-880	21	8	of	of	ADP
brainmatters-880	21	9	gpcrs	gpcrs	PROPN
brainmatters-880	21	10	is	be	AUX
brainmatters-880	21	11	a	a	DET
brainmatters-880	21	12	common	common	ADJ
brainmatters-880	21	13	target	target	NOUN
brainmatters-880	21	14	for	for	ADP
brainmatters-880	21	15	drugs	drug	NOUN
brainmatters-880	21	16	that	that	PRON
brainmatters-880	21	17	treat	treat	VERB
brainmatters-880	21	18	disorders	disorder	NOUN
brainmatters-880	21	19	of	of	ADP
brainmatters-880	21	20	such	such	ADJ
brainmatters-880	21	21	functions	function	NOUN
brainmatters-880	21	22	.	.	PUNCT
brainmatters-880	22	1	how	how	SCONJ
brainmatters-880	22	2	are	be	AUX
brainmatters-880	22	3	gpcrs	gpcrs	PROPN
brainmatters-880	22	4	structured	structure	VERB
brainmatters-880	22	5	?	?	PUNCT
brainmatters-880	23	1	being	be	AUX
brainmatters-880	23	2	able	able	ADJ
brainmatters-880	23	3	to	to	PART
brainmatters-880	23	4	answer	answer	VERB
brainmatters-880	23	5	questions	question	NOUN
brainmatters-880	23	6	about	about	ADP
brainmatters-880	23	7	how	how	SCONJ
brainmatters-880	23	8	something	something	PRON
brainmatters-880	23	9	is	be	AUX
brainmatters-880	23	10	structured	structure	VERB
brainmatters-880	23	11	can	can	AUX
brainmatters-880	23	12	often	often	ADV
brainmatters-880	23	13	give	give	VERB
brainmatters-880	23	14	us	we	PRON
brainmatters-880	23	15	some	some	DET
brainmatters-880	23	16	clue	clue	NOUN
brainmatters-880	23	17	as	as	ADP
brainmatters-880	23	18	to	to	ADP
brainmatters-880	23	19	how	how	SCONJ
brainmatters-880	23	20	it	it	PRON
brainmatters-880	23	21	works	work	VERB
brainmatters-880	23	22	.	.	PUNCT
brainmatters-880	24	1	gpcrs	gpcrs	PROPN
brainmatters-880	24	2	typically	typically	ADV
brainmatters-880	24	3	have	have	VERB
brainmatters-880	24	4	seven	seven	NUM
brainmatters-880	24	5	domains	domain	NOUN
brainmatters-880	24	6	,	,	PUNCT
brainmatters-880	24	7	or	or	CCONJ
brainmatters-880	24	8	segments	segment	NOUN
brainmatters-880	24	9	,	,	PUNCT
brainmatters-880	24	10	that	that	PRON
brainmatters-880	24	11	are	be	AUX
brainmatters-880	24	12	membrane	membrane	NOUN
brainmatters-880	24	13	-	-	PUNCT
brainmatters-880	24	14	spanning	span	VERB
brainmatters-880	24	15	,	,	PUNCT
brainmatters-880	24	16	meaning	mean	VERB
brainmatters-880	24	17	that	that	SCONJ
brainmatters-880	24	18	they	they	PRON
brainmatters-880	24	19	wind	wind	VERB
brainmatters-880	24	20	back	back	ADV
brainmatters-880	24	21	and	and	CCONJ
brainmatters-880	24	22	forth	forth	ADV
brainmatters-880	24	23	across	across	ADP
brainmatters-880	24	24	the	the	DET
brainmatters-880	24	25	plasma	plasma	NOUN
brainmatters-880	24	26	membrane	membrane	NOUN
brainmatters-880	24	27	of	of	ADP
brainmatters-880	24	28	the	the	DET
brainmatters-880	24	29	cell	cell	NOUN
brainmatters-880	24	30	.	.	PUNCT
brainmatters-880	25	1	they	they	PRON
brainmatters-880	25	2	also	also	ADV
brainmatters-880	25	3	contain	contain	VERB
brainmatters-880	25	4	extracellular	extracellular	ADJ
brainmatters-880	25	5	loops	loop	NOUN
brainmatters-880	25	6	that	that	PRON
brainmatters-880	25	7	contain	contain	VERB
brainmatters-880	25	8	components	component	NOUN
brainmatters-880	25	9	that	that	PRON
brainmatters-880	25	10	stabilize	stabilize	VERB
brainmatters-880	25	11	the	the	DET
brainmatters-880	25	12	structure	structure	NOUN
brainmatters-880	25	13	.	.	PUNCT
brainmatters-880	26	1	gpcrs	gpcrs	PROPN
brainmatters-880	26	2	interact	interact	VERB
brainmatters-880	26	3	with	with	ADP
brainmatters-880	26	4	g	g	NOUN
brainmatters-880	26	5	-	-	PUNCT
brainmatters-880	26	6	proteins	protein	NOUN
brainmatters-880	26	7	,	,	PUNCT
brainmatters-880	26	8	named	name	VERB
brainmatters-880	26	9	for	for	ADP
brainmatters-880	26	10	their	their	PRON
brainmatters-880	26	11	ability	ability	NOUN
brainmatters-880	26	12	to	to	PART
brainmatters-880	26	13	bind	bind	VERB
brainmatters-880	26	14	to	to	ADP
brainmatters-880	26	15	gtp	gtp	NOUN
brainmatters-880	26	16	and	and	CCONJ
brainmatters-880	26	17	gdp	gdp	PROPN
brainmatters-880	26	18	.	.	PUNCT
brainmatters-880	27	1	the	the	DET
brainmatters-880	27	2	g	g	NOUN
brainmatters-880	27	3	-	-	PUNCT
brainmatters-880	27	4	protein	protein	NOUN
brainmatters-880	27	5	is	be	AUX
brainmatters-880	27	6	a	a	DET
brainmatters-880	27	7	lipidanchored	lipidanchored	ADJ
brainmatters-880	27	8	protein	protein	NOUN
brainmatters-880	27	9	,	,	PUNCT
brainmatters-880	27	10	which	which	PRON
brainmatters-880	27	11	means	mean	VERB
brainmatters-880	27	12	that	that	SCONJ
brainmatters-880	27	13	it	it	PRON
brainmatters-880	27	14	is	be	AUX
brainmatters-880	27	15	attached	attach	VERB
brainmatters-880	27	16	to	to	ADP
brainmatters-880	27	17	the	the	DET
brainmatters-880	27	18	intracellular	intracellular	ADJ
brainmatters-880	27	19	side	side	NOUN
brainmatters-880	27	20	of	of	ADP
brainmatters-880	27	21	the	the	DET
brainmatters-880	27	22	membrane	membrane	NOUN
brainmatters-880	27	23	and	and	CCONJ
brainmatters-880	27	24	consists	consist	VERB
brainmatters-880	27	25	of	of	ADP
brainmatters-880	27	26	an	an	DET
brainmatters-880	27	27	alpha	alpha	NOUN
brainmatters-880	27	28	subunit	subunit	NOUN
brainmatters-880	27	29	and	and	CCONJ
brainmatters-880	27	30	a	a	DET
brainmatters-880	27	31	β	β	NOUN
brainmatters-880	27	32	/	/	SYM
brainmatters-880	27	33	gamma	gamma	NOUN
brainmatters-880	27	34	dimer	dimer	NOUN
brainmatters-880	27	35	.	.	PUNCT
brainmatters-880	28	1	in	in	ADP
brainmatters-880	28	2	its	its	PRON
brainmatters-880	28	3	inactivated	inactivated	ADJ
brainmatters-880	28	4	state	state	NOUN
brainmatters-880	28	5	,	,	PUNCT
brainmatters-880	28	6	the	the	DET
brainmatters-880	28	7	gprotein	gprotein	NOUN
brainmatters-880	28	8	binds	bind	VERB
brainmatters-880	28	9	gdp	gdp	PROPN
brainmatters-880	28	10	(	(	PUNCT
brainmatters-880	28	11	brooker	brooker	PROPN
brainmatters-880	28	12	et	et	PROPN
brainmatters-880	28	13	al	al	PROPN
brainmatters-880	28	14	.	.	PROPN
brainmatters-880	28	15	,	,	PUNCT
brainmatters-880	28	16	2022	2022	NUM
brainmatters-880	28	17	)	)	PUNCT
brainmatters-880	28	18	.	.	PUNCT
brainmatters-880	29	1	how	how	SCONJ
brainmatters-880	29	2	do	do	AUX
brainmatters-880	29	3	gpcrs	gpcrs	PROPN
brainmatters-880	29	4	function	function	PROPN
brainmatters-880	29	5	?	?	PUNCT
brainmatters-880	30	1	now	now	ADV
brainmatters-880	30	2	that	that	SCONJ
brainmatters-880	30	3	we	we	PRON
brainmatters-880	30	4	have	have	VERB
brainmatters-880	30	5	a	a	DET
brainmatters-880	30	6	basic	basic	ADJ
brainmatters-880	30	7	understanding	understanding	NOUN
brainmatters-880	30	8	of	of	ADP
brainmatters-880	30	9	how	how	SCONJ
brainmatters-880	30	10	the	the	DET
brainmatters-880	30	11	gpcr	gpcr	ADJ
brainmatters-880	30	12	and	and	CCONJ
brainmatters-880	30	13	g	g	NOUN
brainmatters-880	30	14	-	-	PUNCT
brainmatters-880	30	15	protein	protein	NOUN
brainmatters-880	30	16	are	be	AUX
brainmatters-880	30	17	structured	structure	VERB
brainmatters-880	30	18	,	,	PUNCT
brainmatters-880	30	19	let	let	VERB
brainmatters-880	30	20	us	we	PRON
brainmatters-880	30	21	examine	examine	VERB
brainmatters-880	30	22	how	how	SCONJ
brainmatters-880	30	23	they	they	PRON
brainmatters-880	30	24	function	function	VERB
brainmatters-880	30	25	to	to	PART
brainmatters-880	30	26	carry	carry	VERB
brainmatters-880	30	27	out	out	ADP
brainmatters-880	30	28	cellular	cellular	ADJ
brainmatters-880	30	29	responses	response	NOUN
brainmatters-880	30	30	when	when	SCONJ
brainmatters-880	30	31	they	they	PRON
brainmatters-880	30	32	are	be	AUX
brainmatters-880	30	33	functional	functional	ADJ
brainmatters-880	30	34	.	.	PUNCT
brainmatters-880	31	1	to	to	PART
brainmatters-880	31	2	begin	begin	VERB
brainmatters-880	31	3	the	the	DET
brainmatters-880	31	4	signal	signal	ADJ
brainmatters-880	31	5	transduction	transduction	NOUN
brainmatters-880	31	6	pathway	pathway	NOUN
brainmatters-880	31	7	,	,	PUNCT
brainmatters-880	31	8	a	a	DET
brainmatters-880	31	9	ligand	ligand	NOUN
brainmatters-880	31	10	,	,	PUNCT
brainmatters-880	31	11	or	or	CCONJ
brainmatters-880	31	12	signaling	signal	VERB
brainmatters-880	31	13	molecule	molecule	NOUN
brainmatters-880	31	14	such	such	ADJ
brainmatters-880	31	15	as	as	ADP
brainmatters-880	31	16	a	a	DET
brainmatters-880	31	17	hormone	hormone	NOUN
brainmatters-880	31	18	,	,	PUNCT
brainmatters-880	31	19	peptide	peptide	NOUN
brainmatters-880	31	20	,	,	PUNCT
brainmatters-880	31	21	or	or	CCONJ
brainmatters-880	31	22	growth	growth	NOUN
brainmatters-880	31	23	factor	factor	NOUN
brainmatters-880	31	24	binds	bind	VERB
brainmatters-880	31	25	to	to	ADP
brainmatters-880	31	26	the	the	DET
brainmatters-880	31	27	extracellular	extracellular	ADJ
brainmatters-880	31	28	portion	portion	NOUN
brainmatters-880	31	29	of	of	ADP
brainmatters-880	31	30	the	the	DET
brainmatters-880	31	31	receptor	receptor	NOUN
brainmatters-880	31	32	.	.	PUNCT
brainmatters-880	32	1	this	this	PRON
brainmatters-880	32	2	causes	cause	VERB
brainmatters-880	32	3	a	a	DET
brainmatters-880	32	4	conformational	conformational	ADJ
brainmatters-880	32	5	change	change	NOUN
brainmatters-880	32	6	which	which	PRON
brainmatters-880	32	7	allows	allow	VERB
brainmatters-880	32	8	the	the	DET
brainmatters-880	32	9	receptor	receptor	NOUN
brainmatters-880	32	10	to	to	PART
brainmatters-880	32	11	bind	bind	VERB
brainmatters-880	32	12	to	to	ADP
brainmatters-880	32	13	a	a	DET
brainmatters-880	32	14	g	g	NOUN
brainmatters-880	32	15	-	-	PUNCT
brainmatters-880	32	16	protein	protein	NOUN
brainmatters-880	32	17	.	.	PUNCT
brainmatters-880	33	1	once	once	ADV
brainmatters-880	33	2	bound	bind	VERB
brainmatters-880	33	3	to	to	ADP
brainmatters-880	33	4	the	the	DET
brainmatters-880	33	5	receptor	receptor	NOUN
brainmatters-880	33	6	,	,	PUNCT
brainmatters-880	33	7	the	the	DET
brainmatters-880	33	8	g	g	NOUN
brainmatters-880	33	9	-	-	PUNCT
brainmatters-880	33	10	protein	protein	NOUN
brainmatters-880	33	11	a	a	DET
brainmatters-880	33	12	subunit	subunit	NOUN
brainmatters-880	33	13	and	and	CCONJ
brainmatters-880	33	14	β	β	X
brainmatters-880	33	15	/	/	SYM
brainmatters-880	33	16	g	g	PROPN
brainmatters-880	33	17	dimer	dimer	NOUN
brainmatters-880	33	18	separate	separate	ADJ
brainmatters-880	33	19	,	,	PUNCT
brainmatters-880	33	20	releasing	release	VERB
brainmatters-880	33	21	gdp	gdp	NOUN
brainmatters-880	33	22	.	.	PUNCT
brainmatters-880	34	1	this	this	PRON
brainmatters-880	34	2	allows	allow	VERB
brainmatters-880	34	3	the	the	DET
brainmatters-880	34	4	alpha	alpha	ADJ
brainmatters-880	34	5	subunit	subunit	NOUN
brainmatters-880	34	6	to	to	PART
brainmatters-880	34	7	bind	bind	VERB
brainmatters-880	34	8	gtp	gtp	PROPN
brainmatters-880	34	9	.	.	PUNCT
brainmatters-880	35	1	figure	figure	NOUN
brainmatters-880	35	2	1	1	NUM
brainmatters-880	35	3	.	.	PUNCT
brainmatters-880	35	4	schematic	schematic	ADJ
brainmatters-880	35	5	diagram	diagram	NOUN
brainmatters-880	35	6	of	of	ADP
brainmatters-880	35	7	gpcr	gpcr	ADJ
brainmatters-880	35	8	structure	structure	NOUN
brainmatters-880	35	9	(	(	PUNCT
brainmatters-880	35	10	neumann	neumann	PROPN
brainmatters-880	35	11	et	et	PROPN
brainmatters-880	35	12	al	al	PROPN
brainmatters-880	35	13	.	.	PROPN
brainmatters-880	35	14	,	,	PUNCT
brainmatters-880	35	15	2014	2014	NUM
brainmatters-880	35	16	)	)	PUNCT
brainmatters-880	35	17	.	.	PUNCT
brainmatters-880	36	1	4brain	4brain	NUM
brainmatters-880	36	2	matters	matter	VERB
brainmatters-880	36	3	volume	volume	NOUN
brainmatters-880	36	4	vi	vi	PROPN
brainmatters-880	37	1	the	the	DET
brainmatters-880	37	2	two	two	NUM
brainmatters-880	37	3	components	component	NOUN
brainmatters-880	37	4	of	of	ADP
brainmatters-880	37	5	the	the	DET
brainmatters-880	37	6	g	g	NOUN
brainmatters-880	37	7	-	-	PUNCT
brainmatters-880	37	8	protein	protein	NOUN
brainmatters-880	37	9	can	can	AUX
brainmatters-880	37	10	both	both	PRON
brainmatters-880	37	11	play	play	VERB
brainmatters-880	37	12	separate	separate	ADJ
brainmatters-880	37	13	,	,	PUNCT
brainmatters-880	37	14	very	very	ADV
brainmatters-880	37	15	important	important	ADJ
brainmatters-880	37	16	roles	role	NOUN
brainmatters-880	37	17	in	in	ADP
brainmatters-880	37	18	eliciting	elicit	VERB
brainmatters-880	37	19	cellular	cellular	ADJ
brainmatters-880	37	20	responses	response	NOUN
brainmatters-880	37	21	.	.	PUNCT
brainmatters-880	38	1	for	for	ADP
brainmatters-880	38	2	example	example	NOUN
brainmatters-880	38	3	,	,	PUNCT
brainmatters-880	38	4	the	the	DET
brainmatters-880	38	5	a	a	DET
brainmatters-880	38	6	subunit	subunit	NOUN
brainmatters-880	38	7	can	can	AUX
brainmatters-880	38	8	activate	activate	VERB
brainmatters-880	38	9	enzymes	enzyme	NOUN
brainmatters-880	38	10	in	in	ADP
brainmatters-880	38	11	the	the	DET
brainmatters-880	38	12	cell	cell	NOUN
brainmatters-880	38	13	that	that	PRON
brainmatters-880	38	14	lead	lead	VERB
brainmatters-880	38	15	,	,	PUNCT
brainmatters-880	38	16	in	in	ADP
brainmatters-880	38	17	a	a	DET
brainmatters-880	38	18	chain	chain	NOUN
brainmatters-880	38	19	reaction	reaction	NOUN
brainmatters-880	38	20	,	,	PUNCT
brainmatters-880	38	21	to	to	ADP
brainmatters-880	38	22	the	the	DET
brainmatters-880	38	23	increased	increase	VERB
brainmatters-880	38	24	or	or	CCONJ
brainmatters-880	38	25	decreased	decrease	VERB
brainmatters-880	38	26	production	production	NOUN
brainmatters-880	38	27	of	of	ADP
brainmatters-880	38	28	important	important	ADJ
brainmatters-880	38	29	energy	energy	NOUN
brainmatters-880	38	30	sources	source	NOUN
brainmatters-880	38	31	such	such	ADJ
brainmatters-880	38	32	as	as	ADP
brainmatters-880	38	33	glucose	glucose	NOUN
brainmatters-880	38	34	.	.	PUNCT
brainmatters-880	39	1	the	the	DET
brainmatters-880	39	2	b	b	NOUN
brainmatters-880	39	3	/	/	SYM
brainmatters-880	39	4	g	g	NOUN
brainmatters-880	39	5	dimer	dimer	NOUN
brainmatters-880	39	6	is	be	AUX
brainmatters-880	39	7	also	also	ADV
brainmatters-880	39	8	important	important	ADJ
brainmatters-880	39	9	,	,	PUNCT
brainmatters-880	39	10	as	as	SCONJ
brainmatters-880	39	11	it	it	PRON
brainmatters-880	39	12	can	can	AUX
brainmatters-880	39	13	play	play	VERB
brainmatters-880	39	14	a	a	DET
brainmatters-880	39	15	role	role	NOUN
brainmatters-880	39	16	in	in	ADP
brainmatters-880	39	17	the	the	DET
brainmatters-880	39	18	regulation	regulation	NOUN
brainmatters-880	39	19	of	of	ADP
brainmatters-880	39	20	ion	ion	NOUN
brainmatters-880	39	21	channels	channel	NOUN
brainmatters-880	39	22	(	(	PUNCT
brainmatters-880	39	23	brooker	brooker	PROPN
brainmatters-880	39	24	et	et	PROPN
brainmatters-880	39	25	al	al	PROPN
brainmatters-880	39	26	.	.	PROPN
brainmatters-880	39	27	,	,	PUNCT
brainmatters-880	39	28	2022	2022	NUM
brainmatters-880	39	29	)	)	PUNCT
brainmatters-880	39	30	.	.	PUNCT
brainmatters-880	40	1	how	how	SCONJ
brainmatters-880	40	2	do	do	AUX
brainmatters-880	40	3	gpcrs	gpcrs	PROPN
brainmatters-880	40	4	relate	relate	VERB
brainmatters-880	40	5	to	to	ADP
brainmatters-880	40	6	alzheimer	alzheimer	PROPN
brainmatters-880	40	7	’s	’s	PART
brainmatters-880	40	8	?	?	PUNCT
brainmatters-880	41	1	alzheimer	alzheimer	PROPN
brainmatters-880	41	2	’s	’s	PART
brainmatters-880	41	3	disease	disease	NOUN
brainmatters-880	41	4	(	(	PUNCT
brainmatters-880	41	5	ad	ad	NOUN
brainmatters-880	41	6	)	)	PUNCT
brainmatters-880	41	7	is	be	AUX
brainmatters-880	41	8	a	a	DET
brainmatters-880	41	9	neurodegenerative	neurodegenerative	ADJ
brainmatters-880	41	10	disorder	disorder	NOUN
brainmatters-880	41	11	associated	associate	VERB
brainmatters-880	41	12	with	with	ADP
brainmatters-880	41	13	reduced	reduced	ADJ
brainmatters-880	41	14	cognitive	cognitive	ADJ
brainmatters-880	41	15	function	function	NOUN
brainmatters-880	41	16	,	,	PUNCT
brainmatters-880	41	17	loss	loss	NOUN
brainmatters-880	41	18	of	of	ADP
brainmatters-880	41	19	synapses	synapsis	NOUN
brainmatters-880	41	20	,	,	PUNCT
brainmatters-880	41	21	and	and	CCONJ
brainmatters-880	41	22	neurofibrillary	neurofibrillary	ADJ
brainmatters-880	41	23	degeneration	degeneration	NOUN
brainmatters-880	41	24	,	,	PUNCT
brainmatters-880	41	25	or	or	CCONJ
brainmatters-880	41	26	the	the	DET
brainmatters-880	41	27	formation	formation	NOUN
brainmatters-880	41	28	of	of	ADP
brainmatters-880	41	29	tangles	tangle	NOUN
brainmatters-880	41	30	of	of	ADP
brainmatters-880	41	31	fibers	fiber	NOUN
brainmatters-880	41	32	within	within	ADP
brainmatters-880	41	33	nerve	nerve	NOUN
brainmatters-880	41	34	cells	cell	NOUN
brainmatters-880	41	35	,	,	PUNCT
brainmatters-880	41	36	due	due	ADP
brainmatters-880	41	37	to	to	ADP
brainmatters-880	41	38	a	a	DET
brainmatters-880	41	39	buildup	buildup	NOUN
brainmatters-880	41	40	of	of	ADP
brainmatters-880	41	41	plaques	plaque	NOUN
brainmatters-880	41	42	in	in	ADP
brainmatters-880	41	43	the	the	DET
brainmatters-880	41	44	brain	brain	NOUN
brainmatters-880	41	45	.	.	PUNCT
brainmatters-880	42	1	these	these	DET
brainmatters-880	42	2	plaque	plaque	NOUN
brainmatters-880	42	3	buildups	buildup	NOUN
brainmatters-880	42	4	are	be	AUX
brainmatters-880	42	5	accumulations	accumulation	NOUN
brainmatters-880	42	6	of	of	ADP
brainmatters-880	42	7	β	β	NOUN
brainmatters-880	42	8	-	-	NOUN
brainmatters-880	42	9	amyloid	amyloid	NOUN
brainmatters-880	42	10	peptide	peptide	NOUN
brainmatters-880	42	11	(	(	PUNCT
brainmatters-880	42	12	aβ	aβ	NOUN
brainmatters-880	42	13	)	)	PUNCT
brainmatters-880	42	14	,	,	PUNCT
brainmatters-880	42	15	which	which	PRON
brainmatters-880	42	16	is	be	AUX
brainmatters-880	42	17	formed	form	VERB
brainmatters-880	42	18	from	from	ADP
brainmatters-880	42	19	a	a	DET
brainmatters-880	42	20	protein	protein	NOUN
brainmatters-880	42	21	called	call	VERB
brainmatters-880	42	22	amyloid	amyloid	NOUN
brainmatters-880	42	23	protein	protein	NOUN
brainmatters-880	42	24	precursor	precursor	NOUN
brainmatters-880	42	25	(	(	PUNCT
brainmatters-880	42	26	app	app	PROPN
brainmatters-880	42	27	)	)	PUNCT
brainmatters-880	42	28	(	(	PUNCT
brainmatters-880	42	29	zhao	zhao	PROPN
brainmatters-880	42	30	et	et	PROPN
brainmatters-880	42	31	al	al	PROPN
brainmatters-880	42	32	.	.	PROPN
brainmatters-880	42	33	,	,	PUNCT
brainmatters-880	42	34	2016	2016	NUM
brainmatters-880	42	35	)	)	PUNCT
brainmatters-880	42	36	.	.	PUNCT
brainmatters-880	43	1	as	as	SCONJ
brainmatters-880	43	2	stated	state	VERB
brainmatters-880	43	3	before	before	ADV
brainmatters-880	43	4	,	,	PUNCT
brainmatters-880	43	5	gpcrs	gpcrs	PROPN
brainmatters-880	43	6	are	be	AUX
brainmatters-880	43	7	involved	involve	VERB
brainmatters-880	43	8	in	in	ADP
brainmatters-880	43	9	the	the	DET
brainmatters-880	43	10	normal	normal	ADJ
brainmatters-880	43	11	functioning	functioning	NOUN
brainmatters-880	43	12	of	of	ADP
brainmatters-880	43	13	many	many	ADJ
brainmatters-880	43	14	important	important	ADJ
brainmatters-880	43	15	cellular	cellular	ADJ
brainmatters-880	43	16	processes	process	NOUN
brainmatters-880	43	17	in	in	ADP
brainmatters-880	43	18	the	the	DET
brainmatters-880	43	19	brain	brain	NOUN
brainmatters-880	43	20	.	.	PUNCT
brainmatters-880	44	1	one	one	NUM
brainmatters-880	44	2	example	example	NOUN
brainmatters-880	44	3	of	of	ADP
brainmatters-880	44	4	this	this	PRON
brainmatters-880	44	5	is	be	AUX
brainmatters-880	44	6	demonstrated	demonstrate	VERB
brainmatters-880	44	7	in	in	ADP
brainmatters-880	44	8	gpcrs	gpcrs	NOUN
brainmatters-880	44	9	’	'	PUNCT
brainmatters-880	44	10	role	role	NOUN
brainmatters-880	44	11	in	in	ADP
brainmatters-880	44	12	the	the	DET
brainmatters-880	44	13	development	development	NOUN
brainmatters-880	44	14	of	of	ADP
brainmatters-880	44	15	ad	ad	NOUN
brainmatters-880	44	16	through	through	ADP
brainmatters-880	44	17	the	the	DET
brainmatters-880	44	18	processing	processing	NOUN
brainmatters-880	44	19	of	of	ADP
brainmatters-880	44	20	app	app	PROPN
brainmatters-880	44	21	.	.	PUNCT
brainmatters-880	45	1	gpcrs	gpcrs	PROPN
brainmatters-880	45	2	and	and	CCONJ
brainmatters-880	45	3	the	the	DET
brainmatters-880	45	4	regulation	regulation	NOUN
brainmatters-880	45	5	of	of	ADP
brainmatters-880	45	6	app	app	NOUN
brainmatters-880	45	7	through	through	ADP
brainmatters-880	45	8	bace1	bace1	NOUN
brainmatters-880	45	9	downregulation	downregulation	NOUN
brainmatters-880	45	10	bace1	bace1	NOUN
brainmatters-880	45	11	is	be	AUX
brainmatters-880	45	12	an	an	DET
brainmatters-880	45	13	enzyme	enzyme	NOUN
brainmatters-880	45	14	that	that	PRON
brainmatters-880	45	15	is	be	AUX
brainmatters-880	45	16	essential	essential	ADJ
brainmatters-880	45	17	for	for	ADP
brainmatters-880	45	18	the	the	DET
brainmatters-880	45	19	processing	processing	NOUN
brainmatters-880	45	20	of	of	ADP
brainmatters-880	45	21	app	app	NOUN
brainmatters-880	45	22	and	and	CCONJ
brainmatters-880	45	23	generation	generation	NOUN
brainmatters-880	45	24	of	of	ADP
brainmatters-880	45	25	b	b	NOUN
brainmatters-880	45	26	-	-	PUNCT
brainmatters-880	45	27	amyloid	amyloid	NOUN
brainmatters-880	45	28	.	.	PUNCT
brainmatters-880	46	1	in	in	ADP
brainmatters-880	46	2	patients	patient	NOUN
brainmatters-880	46	3	with	with	ADP
brainmatters-880	46	4	ad	ad	NOUN
brainmatters-880	46	5	,	,	PUNCT
brainmatters-880	46	6	bace1	bace1	NOUN
brainmatters-880	46	7	has	have	AUX
brainmatters-880	46	8	been	be	AUX
brainmatters-880	46	9	found	find	VERB
brainmatters-880	46	10	to	to	PART
brainmatters-880	46	11	be	be	AUX
brainmatters-880	46	12	overactive	overactive	ADJ
brainmatters-880	46	13	,	,	PUNCT
brainmatters-880	46	14	but	but	CCONJ
brainmatters-880	46	15	not	not	PART
brainmatters-880	46	16	in	in	ADP
brainmatters-880	46	17	excess	excess	ADJ
brainmatters-880	46	18	(	(	PUNCT
brainmatters-880	46	19	zhao	zhao	X
brainmatters-880	46	20	et	et	PROPN
brainmatters-880	46	21	al	al	PROPN
brainmatters-880	46	22	.	.	PROPN
brainmatters-880	46	23	,	,	PUNCT
brainmatters-880	46	24	2016	2016	NUM
brainmatters-880	46	25	)	)	PUNCT
brainmatters-880	46	26	.	.	PUNCT
brainmatters-880	47	1	research	research	NOUN
brainmatters-880	47	2	suggests	suggest	VERB
brainmatters-880	47	3	that	that	SCONJ
brainmatters-880	47	4	gpcrs	gpcrs	PROPN
brainmatters-880	47	5	(	(	PUNCT
brainmatters-880	47	6	specifically	specifically	ADV
brainmatters-880	47	7	the	the	DET
brainmatters-880	47	8	m1	m1	PROPN
brainmatters-880	47	9	achr	achr	PROPN
brainmatters-880	47	10	,	,	PUNCT
brainmatters-880	47	11	δ	δ	PROPN
brainmatters-880	47	12	-	-	PUNCT
brainmatters-880	47	13	opioid	opioid	ADJ
brainmatters-880	47	14	receptor	receptor	NOUN
brainmatters-880	47	15	,	,	PUNCT
brainmatters-880	47	16	and	and	CCONJ
brainmatters-880	47	17	a2a	a2a	PROPN
brainmatters-880	47	18	receptors	receptor	NOUN
brainmatters-880	47	19	)	)	PUNCT
brainmatters-880	47	20	are	be	AUX
brainmatters-880	47	21	involved	involve	VERB
brainmatters-880	47	22	in	in	ADP
brainmatters-880	47	23	the	the	DET
brainmatters-880	47	24	regulation	regulation	NOUN
brainmatters-880	47	25	of	of	ADP
brainmatters-880	47	26	bace1	bace1	PROPN
brainmatters-880	47	27	(	(	PUNCT
brainmatters-880	47	28	zhao	zhao	PROPN
brainmatters-880	47	29	et	et	PROPN
brainmatters-880	47	30	al	al	PROPN
brainmatters-880	47	31	.	.	PROPN
brainmatters-880	47	32	,	,	PUNCT
brainmatters-880	47	33	2016	2016	NUM
brainmatters-880	47	34	)	)	PUNCT
brainmatters-880	47	35	.	.	PUNCT
brainmatters-880	48	1	there	there	PRON
brainmatters-880	48	2	are	be	VERB
brainmatters-880	48	3	also	also	ADV
brainmatters-880	48	4	a	a	DET
brainmatters-880	48	5	number	number	NOUN
brainmatters-880	48	6	of	of	ADP
brainmatters-880	48	7	different	different	ADJ
brainmatters-880	48	8	proteins	protein	NOUN
brainmatters-880	48	9	that	that	PRON
brainmatters-880	48	10	are	be	AUX
brainmatters-880	48	11	responsible	responsible	ADJ
brainmatters-880	48	12	for	for	ADP
brainmatters-880	48	13	the	the	DET
brainmatters-880	48	14	regulation	regulation	NOUN
brainmatters-880	48	15	of	of	ADP
brainmatters-880	48	16	gpcrs	gpcrs	PROPN
brainmatters-880	48	17	,	,	PUNCT
brainmatters-880	48	18	and	and	CCONJ
brainmatters-880	48	19	therefore	therefore	ADV
brainmatters-880	48	20	may	may	AUX
brainmatters-880	48	21	be	be	AUX
brainmatters-880	48	22	responsible	responsible	ADJ
brainmatters-880	48	23	for	for	ADP
brainmatters-880	48	24	regulating	regulate	VERB
brainmatters-880	48	25	bace1	bace1	NOUN
brainmatters-880	48	26	activity	activity	NOUN
brainmatters-880	48	27	.	.	PUNCT
brainmatters-880	49	1	it	it	PRON
brainmatters-880	49	2	has	have	AUX
brainmatters-880	49	3	been	be	AUX
brainmatters-880	49	4	shown	show	VERB
brainmatters-880	49	5	that	that	SCONJ
brainmatters-880	49	6	a	a	DET
brainmatters-880	49	7	loss	loss	NOUN
brainmatters-880	49	8	of	of	ADP
brainmatters-880	49	9	function	function	NOUN
brainmatters-880	49	10	in	in	ADP
brainmatters-880	49	11	these	these	DET
brainmatters-880	49	12	enzymes	enzyme	NOUN
brainmatters-880	49	13	is	be	AUX
brainmatters-880	49	14	also	also	ADV
brainmatters-880	49	15	connected	connect	VERB
brainmatters-880	49	16	to	to	ADP
brainmatters-880	49	17	the	the	DET
brainmatters-880	49	18	progression	progression	NOUN
brainmatters-880	49	19	of	of	ADP
brainmatters-880	49	20	ad	ad	NOUN
brainmatters-880	49	21	in	in	ADP
brainmatters-880	49	22	some	some	DET
brainmatters-880	49	23	way	way	NOUN
brainmatters-880	49	24	or	or	CCONJ
brainmatters-880	49	25	another	another	PRON
brainmatters-880	49	26	(	(	PUNCT
brainmatters-880	49	27	zhao	zhao	PROPN
brainmatters-880	49	28	et	et	PROPN
brainmatters-880	49	29	al	al	PROPN
brainmatters-880	49	30	.	.	PROPN
brainmatters-880	49	31	,	,	PUNCT
brainmatters-880	49	32	2016	2016	NUM
brainmatters-880	49	33	)	)	PUNCT
brainmatters-880	49	34	.	.	PUNCT
brainmatters-880	50	1	for	for	ADP
brainmatters-880	50	2	example	example	NOUN
brainmatters-880	50	3	,	,	PUNCT
brainmatters-880	50	4	the	the	DET
brainmatters-880	50	5	upregulation	upregulation	NOUN
brainmatters-880	50	6	of	of	ADP
brainmatters-880	50	7	small	small	ADJ
brainmatters-880	50	8	gtpases	gtpase	NOUN
brainmatters-880	50	9	such	such	ADJ
brainmatters-880	50	10	as	as	ADP
brainmatters-880	50	11	rabs	rab	NOUN
brainmatters-880	50	12	has	have	AUX
brainmatters-880	50	13	been	be	AUX
brainmatters-880	50	14	connected	connect	VERB
brainmatters-880	50	15	to	to	ADP
brainmatters-880	50	16	cognitive	cognitive	ADJ
brainmatters-880	50	17	impairment	impairment	NOUN
brainmatters-880	50	18	in	in	ADP
brainmatters-880	50	19	ad	ad	NOUN
brainmatters-880	50	20	(	(	PUNCT
brainmatters-880	50	21	ginsberg	ginsberg	PROPN
brainmatters-880	50	22	et	et	PROPN
brainmatters-880	50	23	al	al	PROPN
brainmatters-880	50	24	.	.	PROPN
brainmatters-880	50	25	,	,	PUNCT
brainmatters-880	50	26	2010	2010	NUM
brainmatters-880	50	27	)	)	PUNCT
brainmatters-880	50	28	.	.	PUNCT
brainmatters-880	51	1	although	although	SCONJ
brainmatters-880	51	2	there	there	PRON
brainmatters-880	51	3	is	be	VERB
brainmatters-880	51	4	evidence	evidence	NOUN
brainmatters-880	51	5	for	for	ADP
brainmatters-880	51	6	a	a	DET
brainmatters-880	51	7	linkage	linkage	NOUN
brainmatters-880	51	8	of	of	ADP
brainmatters-880	51	9	gpcrs	gpcrs	PROPN
brainmatters-880	51	10	to	to	ADP
brainmatters-880	51	11	the	the	DET
brainmatters-880	51	12	regulation	regulation	NOUN
brainmatters-880	51	13	of	of	ADP
brainmatters-880	51	14	bace1	bace1	PROPN
brainmatters-880	51	15	,	,	PUNCT
brainmatters-880	51	16	it	it	PRON
brainmatters-880	51	17	is	be	AUX
brainmatters-880	51	18	not	not	PART
brainmatters-880	51	19	currently	currently	ADV
brainmatters-880	51	20	known	know	VERB
brainmatters-880	51	21	exactly	exactly	ADV
brainmatters-880	51	22	the	the	DET
brainmatters-880	51	23	mechanism	mechanism	NOUN
brainmatters-880	51	24	through	through	ADP
brainmatters-880	51	25	which	which	PRON
brainmatters-880	51	26	it	it	PRON
brainmatters-880	51	27	is	be	AUX
brainmatters-880	51	28	done	do	VERB
brainmatters-880	51	29	.	.	PUNCT
brainmatters-880	52	1	gpcrs	gpcrs	PROPN
brainmatters-880	52	2	and	and	CCONJ
brainmatters-880	52	3	the	the	DET
brainmatters-880	52	4	regulation	regulation	NOUN
brainmatters-880	52	5	of	of	ADP
brainmatters-880	52	6	app	app	NOUN
brainmatters-880	52	7	through	through	ADP
brainmatters-880	52	8	degradation	degradation	NOUN
brainmatters-880	52	9	of	of	ADP
brainmatters-880	52	10	bace1	bace1	NOUN
brainmatters-880	53	1	another	another	DET
brainmatters-880	53	2	possibility	possibility	NOUN
brainmatters-880	53	3	for	for	ADP
brainmatters-880	53	4	a	a	DET
brainmatters-880	53	5	mechanism	mechanism	NOUN
brainmatters-880	53	6	of	of	ADP
brainmatters-880	53	7	regulation	regulation	NOUN
brainmatters-880	53	8	of	of	ADP
brainmatters-880	53	9	app	app	NOUN
brainmatters-880	53	10	by	by	ADP
brainmatters-880	53	11	gpcrs	gpcrs	PROPN
brainmatters-880	53	12	is	be	AUX
brainmatters-880	53	13	related	relate	VERB
brainmatters-880	53	14	to	to	ADP
brainmatters-880	53	15	the	the	DET
brainmatters-880	53	16	degradation	degradation	NOUN
brainmatters-880	53	17	of	of	ADP
brainmatters-880	53	18	bace1	bace1	NOUN
brainmatters-880	53	19	.	.	PUNCT
brainmatters-880	54	1	there	there	PRON
brainmatters-880	54	2	is	be	VERB
brainmatters-880	54	3	evidence	evidence	NOUN
brainmatters-880	54	4	that	that	SCONJ
brainmatters-880	54	5	machr	machr	NOUN
brainmatters-880	54	6	,	,	PUNCT
brainmatters-880	54	7	which	which	PRON
brainmatters-880	54	8	was	be	AUX
brainmatters-880	54	9	previously	previously	ADV
brainmatters-880	54	10	mentioned	mention	VERB
brainmatters-880	54	11	as	as	ADP
brainmatters-880	54	12	a	a	DET
brainmatters-880	54	13	possible	possible	ADJ
brainmatters-880	54	14	component	component	NOUN
brainmatters-880	54	15	of	of	ADP
brainmatters-880	54	16	bace1	bace1	NOUN
brainmatters-880	54	17	downregulation	downregulation	NOUN
brainmatters-880	54	18	,	,	PUNCT
brainmatters-880	54	19	could	could	AUX
brainmatters-880	54	20	be	be	AUX
brainmatters-880	54	21	involved	involve	VERB
brainmatters-880	54	22	in	in	ADP
brainmatters-880	54	23	the	the	DET
brainmatters-880	54	24	degradation	degradation	NOUN
brainmatters-880	54	25	of	of	ADP
brainmatters-880	54	26	bace1	bace1	PROPN
brainmatters-880	55	1	(	(	PUNCT
brainmatters-880	55	2	jiang	jiang	PROPN
brainmatters-880	55	3	et	et	PROPN
brainmatters-880	55	4	al	al	PROPN
brainmatters-880	55	5	.	.	PROPN
brainmatters-880	55	6	,	,	PUNCT
brainmatters-880	55	7	2012	2012	NUM
brainmatters-880	55	8	)	)	PUNCT
brainmatters-880	55	9	.	.	PUNCT
brainmatters-880	56	1	the	the	DET
brainmatters-880	56	2	mechanism	mechanism	NOUN
brainmatters-880	56	3	through	through	ADP
brainmatters-880	56	4	which	which	PRON
brainmatters-880	56	5	this	this	PRON
brainmatters-880	56	6	is	be	AUX
brainmatters-880	56	7	done	do	VERB
brainmatters-880	56	8	is	be	AUX
brainmatters-880	56	9	not	not	PART
brainmatters-880	56	10	clear	clear	ADJ
brainmatters-880	56	11	to	to	ADP
brainmatters-880	56	12	researchers	researcher	NOUN
brainmatters-880	56	13	and	and	CCONJ
brainmatters-880	56	14	is	be	AUX
brainmatters-880	56	15	a	a	DET
brainmatters-880	56	16	continuing	continue	VERB
brainmatters-880	56	17	topic	topic	NOUN
brainmatters-880	56	18	of	of	ADP
brainmatters-880	56	19	discovery	discovery	NOUN
brainmatters-880	56	20	.	.	PUNCT
brainmatters-880	57	1	why	why	SCONJ
brainmatters-880	57	2	is	be	AUX
brainmatters-880	57	3	determining	determine	VERB
brainmatters-880	57	4	these	these	DET
brainmatters-880	57	5	mechanisms	mechanism	NOUN
brainmatters-880	57	6	hard	hard	ADJ
brainmatters-880	57	7	,	,	PUNCT
brainmatters-880	57	8	but	but	CCONJ
brainmatters-880	57	9	also	also	ADV
brainmatters-880	57	10	so	so	ADV
brainmatters-880	57	11	important	important	ADJ
brainmatters-880	57	12	?	?	PUNCT
brainmatters-880	58	1	currently	currently	ADV
brainmatters-880	58	2	,	,	PUNCT
brainmatters-880	58	3	the	the	DET
brainmatters-880	58	4	drugs	drug	NOUN
brainmatters-880	58	5	used	use	VERB
brainmatters-880	58	6	for	for	ADP
brainmatters-880	58	7	the	the	DET
brainmatters-880	58	8	treatment	treatment	NOUN
brainmatters-880	58	9	of	of	ADP
brainmatters-880	58	10	ad	ad	NOUN
brainmatters-880	58	11	only	only	ADV
brainmatters-880	58	12	scratch	scratch	VERB
brainmatters-880	58	13	the	the	DET
brainmatters-880	58	14	surface	surface	NOUN
brainmatters-880	58	15	of	of	ADP
brainmatters-880	58	16	the	the	DET
brainmatters-880	58	17	problem	problem	NOUN
brainmatters-880	58	18	.	.	PUNCT
brainmatters-880	59	1	current	current	ADJ
brainmatters-880	59	2	treatments	treatment	NOUN
brainmatters-880	59	3	such	such	ADJ
brainmatters-880	59	4	as	as	ADP
brainmatters-880	59	5	acetylcholinesterase	acetylcholinesterase	NOUN
brainmatters-880	59	6	inhibitors	inhibitor	NOUN
brainmatters-880	59	7	and	and	CCONJ
brainmatters-880	59	8	memantine	memantine	NOUN
brainmatters-880	59	9	treat	treat	NOUN
brainmatters-880	59	10	only	only	ADV
brainmatters-880	59	11	the	the	DET
brainmatters-880	59	12	symptoms	symptom	NOUN
brainmatters-880	59	13	of	of	ADP
brainmatters-880	59	14	ad	ad	NOUN
brainmatters-880	59	15	.	.	PUNCT
brainmatters-880	60	1	acetylcholinesterase	acetylcholinesterase	NOUN
brainmatters-880	60	2	inhibitors	inhibitor	NOUN
brainmatters-880	60	3	simply	simply	ADV
brainmatters-880	60	4	inhibit	inhibit	VERB
brainmatters-880	60	5	the	the	DET
brainmatters-880	60	6	breakdown	breakdown	NOUN
brainmatters-880	60	7	of	of	ADP
brainmatters-880	60	8	acetylcholine	acetylcholine	NOUN
brainmatters-880	60	9	,	,	PUNCT
brainmatters-880	60	10	which	which	PRON
brainmatters-880	60	11	is	be	AUX
brainmatters-880	60	12	in	in	ADP
brainmatters-880	60	13	short	short	ADJ
brainmatters-880	60	14	supply	supply	NOUN
brainmatters-880	60	15	in	in	ADP
brainmatters-880	60	16	the	the	DET
brainmatters-880	60	17	brains	brain	NOUN
brainmatters-880	60	18	of	of	ADP
brainmatters-880	60	19	ad	ad	NOUN
brainmatters-880	60	20	patients	patient	NOUN
brainmatters-880	60	21	.	.	PUNCT
brainmatters-880	61	1	similarly	similarly	ADV
brainmatters-880	61	2	,	,	PUNCT
brainmatters-880	61	3	memantine	memantine	NOUN
brainmatters-880	61	4	prevents	prevent	VERB
brainmatters-880	61	5	excitotoxicity	excitotoxicity	NOUN
brainmatters-880	61	6	due	due	ADP
brainmatters-880	61	7	to	to	ADP
brainmatters-880	61	8	overstimulation	overstimulation	NOUN
brainmatters-880	61	9	(	(	PUNCT
brainmatters-880	61	10	huang	huang	PROPN
brainmatters-880	61	11	et	et	PROPN
brainmatters-880	61	12	al	al	PROPN
brainmatters-880	61	13	.	.	PROPN
brainmatters-880	61	14	,	,	PUNCT
brainmatters-880	61	15	2017	2017	NUM
brainmatters-880	61	16	)	)	PUNCT
brainmatters-880	61	17	.	.	PUNCT
brainmatters-880	62	1	these	these	DET
brainmatters-880	62	2	treatments	treatment	NOUN
brainmatters-880	62	3	,	,	PUNCT
brainmatters-880	62	4	while	while	SCONJ
brainmatters-880	62	5	helpful	helpful	ADJ
brainmatters-880	62	6	,	,	PUNCT
brainmatters-880	62	7	leave	leave	VERB
brainmatters-880	62	8	the	the	DET
brainmatters-880	62	9	root	root	NOUN
brainmatters-880	62	10	of	of	ADP
brainmatters-880	62	11	the	the	DET
brainmatters-880	62	12	problem	problem	NOUN
brainmatters-880	62	13	unchecked	unchecked	ADJ
brainmatters-880	62	14	.	.	PUNCT
brainmatters-880	63	1	if	if	SCONJ
brainmatters-880	63	2	the	the	DET
brainmatters-880	63	3	mechanisms	mechanism	NOUN
brainmatters-880	63	4	behind	behind	ADP
brainmatters-880	63	5	the	the	DET
brainmatters-880	63	6	role	role	NOUN
brainmatters-880	63	7	of	of	ADP
brainmatters-880	63	8	gpcrs	gpcrs	PROPN
brainmatters-880	63	9	in	in	ADP
brainmatters-880	63	10	the	the	DET
brainmatters-880	63	11	processing	processing	NOUN
brainmatters-880	63	12	of	of	ADP
brainmatters-880	63	13	app	app	NOUN
brainmatters-880	63	14	are	be	AUX
brainmatters-880	63	15	further	far	ADV
brainmatters-880	63	16	studied	study	VERB
brainmatters-880	63	17	,	,	PUNCT
brainmatters-880	63	18	better	well	ADJ
brainmatters-880	63	19	therapies	therapy	NOUN
brainmatters-880	63	20	and	and	CCONJ
brainmatters-880	63	21	even	even	ADV
brainmatters-880	63	22	a	a	DET
brainmatters-880	63	23	possible	possible	ADJ
brainmatters-880	63	24	cure	cure	NOUN
brainmatters-880	63	25	for	for	ADP
brainmatters-880	63	26	alzheimer	alzheimer	PROPN
brainmatters-880	63	27	’s	’s	PART
brainmatters-880	63	28	may	may	AUX
brainmatters-880	63	29	be	be	AUX
brainmatters-880	63	30	on	on	ADP
brainmatters-880	63	31	the	the	DET
brainmatters-880	63	32	horizon	horizon	NOUN
brainmatters-880	63	33	.	.	PUNCT
brainmatters-880	64	1	the	the	DET
brainmatters-880	64	2	problem	problem	NOUN
brainmatters-880	64	3	,	,	PUNCT
brainmatters-880	64	4	however	however	ADV
brainmatters-880	64	5	,	,	PUNCT
brainmatters-880	64	6	is	be	AUX
brainmatters-880	64	7	that	that	SCONJ
brainmatters-880	64	8	there	there	PRON
brainmatters-880	64	9	are	be	VERB
brainmatters-880	64	10	a	a	DET
brainmatters-880	64	11	few	few	ADJ
brainmatters-880	64	12	difficult	difficult	ADJ
brainmatters-880	64	13	tasks	task	NOUN
brainmatters-880	64	14	standing	stand	VERB
brainmatters-880	64	15	in	in	ADP
brainmatters-880	64	16	the	the	DET
brainmatters-880	64	17	way	way	NOUN
brainmatters-880	64	18	of	of	ADP
brainmatters-880	64	19	our	our	PRON
brainmatters-880	64	20	understanding	understanding	NOUN
brainmatters-880	64	21	of	of	ADP
brainmatters-880	64	22	these	these	DET
brainmatters-880	64	23	mechanisms	mechanism	NOUN
brainmatters-880	64	24	.	.	PUNCT
brainmatters-880	65	1	first	first	ADV
brainmatters-880	65	2	,	,	PUNCT
brainmatters-880	65	3	inhibiting	inhibit	VERB
brainmatters-880	65	4	bace1	bace1	NOUN
brainmatters-880	65	5	would	would	AUX
brainmatters-880	65	6	not	not	PART
brainmatters-880	65	7	come	come	VERB
brainmatters-880	65	8	without	without	ADP
brainmatters-880	65	9	side	side	NOUN
brainmatters-880	65	10	effects	effect	NOUN
brainmatters-880	65	11	.	.	PUNCT
brainmatters-880	66	1	inhibiting	inhibit	VERB
brainmatters-880	66	2	bace1	bace1	NOUN
brainmatters-880	66	3	may	may	AUX
brainmatters-880	66	4	prevent	prevent	VERB
brainmatters-880	66	5	unnecessary	unnecessary	ADJ
brainmatters-880	66	6	aβ	aβ	NOUN
brainmatters-880	66	7	production	production	NOUN
brainmatters-880	66	8	,	,	PUNCT
brainmatters-880	66	9	but	but	CCONJ
brainmatters-880	66	10	this	this	PRON
brainmatters-880	66	11	does	do	AUX
brainmatters-880	66	12	not	not	PART
brainmatters-880	66	13	come	come	VERB
brainmatters-880	66	14	without	without	ADP
brainmatters-880	66	15	consequences	consequence	NOUN
brainmatters-880	66	16	in	in	ADP
brainmatters-880	66	17	application	application	NOUN
brainmatters-880	66	18	in	in	ADP
brainmatters-880	66	19	the	the	DET
brainmatters-880	66	20	body	body	NOUN
brainmatters-880	66	21	.	.	PUNCT
brainmatters-880	67	1	there	there	PRON
brainmatters-880	67	2	is	be	VERB
brainmatters-880	67	3	a	a	DET
brainmatters-880	67	4	strong	strong	ADJ
brainmatters-880	67	5	possibility	possibility	NOUN
brainmatters-880	67	6	that	that	SCONJ
brainmatters-880	67	7	bace1	bace1	NOUN
brainmatters-880	67	8	is	be	AUX
brainmatters-880	67	9	related	relate	VERB
brainmatters-880	67	10	to	to	ADP
brainmatters-880	67	11	the	the	DET
brainmatters-880	67	12	production	production	NOUN
brainmatters-880	67	13	of	of	ADP
brainmatters-880	67	14	many	many	ADJ
brainmatters-880	67	15	other	other	ADJ
brainmatters-880	67	16	enzymes	enzyme	NOUN
brainmatters-880	67	17	,	,	PUNCT
brainmatters-880	67	18	so	so	ADV
brainmatters-880	67	19	inhibiting	inhibit	VERB
brainmatters-880	67	20	it	it	PRON
brainmatters-880	67	21	would	would	AUX
brainmatters-880	67	22	affect	affect	VERB
brainmatters-880	67	23	enzymes	enzyme	NOUN
brainmatters-880	67	24	that	that	PRON
brainmatters-880	67	25	were	be	AUX
brainmatters-880	67	26	not	not	PART
brainmatters-880	67	27	meant	mean	VERB
brainmatters-880	67	28	to	to	PART
brainmatters-880	67	29	be	be	AUX
brainmatters-880	67	30	affected	affect	VERB
brainmatters-880	67	31	.	.	PUNCT
brainmatters-880	68	1	this	this	PRON
brainmatters-880	68	2	could	could	AUX
brainmatters-880	68	3	lead	lead	VERB
brainmatters-880	68	4	to	to	ADP
brainmatters-880	68	5	unwanted	unwanted	ADJ
brainmatters-880	68	6	effects	effect	NOUN
brainmatters-880	68	7	such	such	ADJ
brainmatters-880	68	8	as	as	ADP
brainmatters-880	68	9	impaired	impair	VERB
brainmatters-880	68	10	spatial	spatial	ADJ
brainmatters-880	68	11	reference	reference	NOUN
brainmatters-880	68	12	and	and	CCONJ
brainmatters-880	68	13	working	working	NOUN
brainmatters-880	68	14	memory	memory	NOUN
brainmatters-880	68	15	,	,	PUNCT
brainmatters-880	68	16	as	as	ADV
brainmatters-880	68	17	well	well	ADV
brainmatters-880	68	18	as	as	ADP
brainmatters-880	68	19	problems	problem	NOUN
brainmatters-880	68	20	with	with	ADP
brainmatters-880	68	21	temporal	temporal	ADJ
brainmatters-880	68	22	associative	associative	ADJ
brainmatters-880	68	23	memory	memory	NOUN
brainmatters-880	68	24	(	(	PUNCT
brainmatters-880	68	25	cole	cole	PROPN
brainmatters-880	68	26	&	&	CCONJ
brainmatters-880	68	27	vassar	vassar	PROPN
brainmatters-880	68	28	,	,	PUNCT
brainmatters-880	68	29	2007	2007	NUM
brainmatters-880	68	30	)	)	PUNCT
brainmatters-880	68	31	.	.	PUNCT
brainmatters-880	69	1	brain	brain	NOUN
brainmatters-880	69	2	matters	matter	NOUN
brainmatters-880	69	3	volume	volume	VERB
brainmatters-880	69	4	v	v	ADP
brainmatters-880	69	5	5	5	NUM
brainmatters-880	69	6	figure	figure	NOUN
brainmatters-880	69	7	2	2	NUM
brainmatters-880	69	8	.	.	X
brainmatters-880	69	9	diagram	diagram	NOUN
brainmatters-880	69	10	of	of	ADP
brainmatters-880	69	11	general	general	ADJ
brainmatters-880	69	12	signal	signal	NOUN
brainmatters-880	69	13	transduction	transduction	NOUN
brainmatters-880	69	14	pathway	pathway	NOUN
brainmatters-880	69	15	of	of	ADP
brainmatters-880	69	16	gpcrs	gpcrs	PROPN
brainmatters-880	69	17	(	(	PUNCT
brainmatters-880	69	18	tuteja	tuteja	ADJ
brainmatters-880	69	19	,	,	PUNCT
brainmatters-880	69	20	2005	2005	NUM
brainmatters-880	69	21	)	)	PUNCT
brainmatters-880	69	22	.	.	PUNCT
brainmatters-880	70	1	figure	figure	NOUN
brainmatters-880	70	2	3	3	NUM
brainmatters-880	70	3	.	.	PUNCT
brainmatters-880	70	4	proposed	propose	VERB
brainmatters-880	70	5	signal	signal	NOUN
brainmatters-880	70	6	transduction	transduction	NOUN
brainmatters-880	70	7	pathway	pathway	NOUN
brainmatters-880	70	8	and	and	CCONJ
brainmatters-880	70	9	interaction	interaction	NOUN
brainmatters-880	70	10	between	between	ADP
brainmatters-880	70	11	gpcr	gpcr	NOUN
brainmatters-880	70	12	and	and	CCONJ
brainmatters-880	70	13	bace1	bace1	NOUN
brainmatters-880	71	1	(	(	PUNCT
brainmatters-880	71	2	zhao	zhao	PROPN
brainmatters-880	71	3	et	et	PROPN
brainmatters-880	71	4	al	al	PROPN
brainmatters-880	71	5	.	.	PROPN
brainmatters-880	71	6	,	,	PUNCT
brainmatters-880	71	7	2016	2016	NUM
brainmatters-880	71	8	)	)	PUNCT
brainmatters-880	71	9	.	.	PUNCT
brainmatters-880	72	1	azam	azam	PROPN
brainmatters-880	72	2	,	,	PUNCT
brainmatters-880	72	3	s.	s.	PROPN
brainmatters-880	72	4	,	,	PUNCT
brainmatters-880	72	5	haque	haque	PROPN
brainmatters-880	72	6	,	,	PUNCT
brainmatters-880	72	7	m.	m.	PROPN
brainmatters-880	72	8	e.	e.	PROPN
brainmatters-880	72	9	,	,	PUNCT
brainmatters-880	72	10	jakaria	jakaria	PROPN
brainmatters-880	72	11	,	,	PUNCT
brainmatters-880	72	12	m.	m.	NOUN
brainmatters-880	72	13	,	,	PUNCT
brainmatters-880	72	14	jo	jo	PROPN
brainmatters-880	72	15	,	,	PUNCT
brainmatters-880	72	16	s.	s.	PROPN
brainmatters-880	72	17	h.	h.	PROPN
brainmatters-880	72	18	,	,	PUNCT
brainmatters-880	72	19	kim	kim	PROPN
brainmatters-880	72	20	,	,	PUNCT
brainmatters-880	72	21	i.	i.	PROPN
brainmatters-880	72	22	s.	s.	PROPN
brainmatters-880	72	23	,	,	PUNCT
brainmatters-880	72	24	&	&	CCONJ
brainmatters-880	72	25	choi	choi	PROPN
brainmatters-880	72	26	,	,	PUNCT
brainmatters-880	72	27	d.	d.	PROPN
brainmatters-880	72	28	k.	k.	PROPN
brainmatters-880	72	29	(	(	PUNCT
brainmatters-880	72	30	2020	2020	NUM
brainmatters-880	72	31	)	)	PUNCT
brainmatters-880	72	32	.	.	PUNCT
brainmatters-880	73	1	g	g	NOUN
brainmatters-880	73	2	-	-	PUNCT
brainmatters-880	73	3	protein	protein	NOUN
brainmatters-880	73	4	-	-	PUNCT
brainmatters-880	73	5	coupled	couple	VERB
brainmatters-880	73	6	receptors	receptor	NOUN
brainmatters-880	73	7	in	in	ADP
brainmatters-880	73	8	cns	cns	NOUN
brainmatters-880	73	9	:	:	PUNCT
brainmatters-880	73	10	a	a	DET
brainmatters-880	73	11	potential	potential	ADJ
brainmatters-880	73	12	therapeutic	therapeutic	ADJ
brainmatters-880	73	13	target	target	NOUN
brainmatters-880	73	14	for	for	ADP
brainmatters-880	73	15	intervention	intervention	NOUN
brainmatters-880	73	16	in	in	ADP
brainmatters-880	73	17	neurodegenerative	neurodegenerative	ADJ
brainmatters-880	73	18	disorders	disorder	NOUN
brainmatters-880	73	19	and	and	CCONJ
brainmatters-880	73	20	associated	associated	ADJ
brainmatters-880	73	21	cognitive	cognitive	ADJ
brainmatters-880	73	22	deficits	deficit	NOUN
brainmatters-880	73	23	.	.	PUNCT
brainmatters-880	74	1	cells	cell	NOUN
brainmatters-880	74	2	,	,	PUNCT
brainmatters-880	74	3	9(2	9(2	NUM
brainmatters-880	74	4	)	)	PUNCT
brainmatters-880	74	5	,	,	PUNCT
brainmatters-880	74	6	506	506	NUM
brainmatters-880	74	7	.	.	PUNCT
brainmatters-880	74	8	https://doi.org/10.3390/cells9020506	https://doi.org/10.3390/cells9020506	PROPN
brainmatters-880	74	9	brooker	brooker	PROPN
brainmatters-880	74	10	,	,	PUNCT
brainmatters-880	74	11	r.	r.	PROPN
brainmatters-880	74	12	j.	j.	PROPN
brainmatters-880	74	13	,	,	PUNCT
brainmatters-880	74	14	widmaier	widmaier	ADV
brainmatters-880	74	15	,	,	PUNCT
brainmatters-880	74	16	e.	e.	PROPN
brainmatters-880	74	17	p.	p.	PROPN
brainmatters-880	74	18	,	,	PUNCT
brainmatters-880	74	19	graham	graham	PROPN
brainmatters-880	74	20	,	,	PUNCT
brainmatters-880	74	21	l.	l.	PROPN
brainmatters-880	74	22	e.	e.	PROPN
brainmatters-880	74	23	,	,	PUNCT
brainmatters-880	74	24	&	&	CCONJ
brainmatters-880	74	25	stiling	stile	VERB
brainmatters-880	74	26	,	,	PUNCT
brainmatters-880	74	27	p.	p.	PROPN
brainmatters-880	74	28	d.	d.	PROPN
brainmatters-880	74	29	(	(	PUNCT
brainmatters-880	74	30	2022	2022	NUM
brainmatters-880	74	31	)	)	PUNCT
brainmatters-880	74	32	.	.	PUNCT
brainmatters-880	75	1	cell	cell	NOUN
brainmatters-880	75	2	communication	communication	NOUN
brainmatters-880	75	3	.	.	PUNCT
brainmatters-880	76	1	in	in	ADP
brainmatters-880	76	2	biology	biology	NOUN
brainmatters-880	76	3	(	(	PUNCT
brainmatters-880	76	4	pp	pp	ADJ
brainmatters-880	76	5	.	.	PUNCT
brainmatters-880	76	6	85–92	85–92	NUM
brainmatters-880	76	7	)	)	PUNCT
brainmatters-880	76	8	.	.	PUNCT
brainmatters-880	77	1	essay	essay	PROPN
brainmatters-880	77	2	,	,	PUNCT
brainmatters-880	77	3	mcgraw	mcgraw	PROPN
brainmatters-880	77	4	hill	hill	PROPN
brainmatters-880	77	5	llc	llc	PROPN
brainmatters-880	77	6	.	.	PUNCT
brainmatters-880	78	1	cole	cole	PROPN
brainmatters-880	78	2	,	,	PUNCT
brainmatters-880	78	3	s.l	s.l	PROPN
brainmatters-880	78	4	.	.	PROPN
brainmatters-880	78	5	,	,	PUNCT
brainmatters-880	78	6	vassar	vassar	PROPN
brainmatters-880	78	7	,	,	PUNCT
brainmatters-880	78	8	r.	r.	PROPN
brainmatters-880	78	9	the	the	DET
brainmatters-880	78	10	alzheimer	alzheimer	PROPN
brainmatters-880	78	11	's	's	PART
brainmatters-880	78	12	disease	disease	NOUN
brainmatters-880	78	13	βsecretase	βsecretase	NOUN
brainmatters-880	78	14	enzyme	enzyme	NOUN
brainmatters-880	78	15	,	,	PUNCT
brainmatters-880	78	16	bace1	bace1	PROPN
brainmatters-880	78	17	.	.	PUNCT
brainmatters-880	79	1	mol	mol	ADP
brainmatters-880	79	2	neurodegeneration	neurodegeneration	NOUN
brainmatters-880	79	3	2	2	NUM
brainmatters-880	79	4	,	,	PUNCT
brainmatters-880	79	5	22	22	NUM
brainmatters-880	79	6	(	(	PUNCT
brainmatters-880	79	7	2007	2007	NUM
brainmatters-880	79	8	)	)	PUNCT
brainmatters-880	79	9	.	.	PUNCT
brainmatters-880	80	1	https://doi.org/10.1186/1750-1326-2-22	https://doi.org/10.1186/1750-1326-2-22	PROPN
brainmatters-880	80	2	ginsberg	ginsberg	PROPN
brainmatters-880	80	3	,	,	PUNCT
brainmatters-880	80	4	s.	s.	PROPN
brainmatters-880	80	5	d.	d.	PROPN
brainmatters-880	80	6	,	,	PUNCT
brainmatters-880	80	7	alldred	alldre	VERB
brainmatters-880	80	8	,	,	PUNCT
brainmatters-880	80	9	m.	m.	NOUN
brainmatters-880	80	10	j.	j.	PROPN
brainmatters-880	80	11	,	,	PUNCT
brainmatters-880	80	12	counts	count	NOUN
brainmatters-880	80	13	,	,	PUNCT
brainmatters-880	80	14	s.	s.	PROPN
brainmatters-880	80	15	e.	e.	PROPN
brainmatters-880	80	16	,	,	PUNCT
brainmatters-880	80	17	cataldo	cataldo	PROPN
brainmatters-880	80	18	,	,	PUNCT
brainmatters-880	80	19	a.	a.	NOUN
brainmatters-880	80	20	m.	m.	NOUN
brainmatters-880	80	21	,	,	PUNCT
brainmatters-880	80	22	neve	neve	PROPN
brainmatters-880	80	23	,	,	PUNCT
brainmatters-880	80	24	r.	r.	PROPN
brainmatters-880	80	25	l.	l.	PROPN
brainmatters-880	80	26	,	,	PUNCT
brainmatters-880	80	27	jiang	jiang	PROPN
brainmatters-880	80	28	,	,	PUNCT
brainmatters-880	80	29	y.	y.	PROPN
brainmatters-880	80	30	,	,	PUNCT
brainmatters-880	80	31	wuu	wuu	PROPN
brainmatters-880	80	32	,	,	PUNCT
brainmatters-880	80	33	j.	j.	PROPN
brainmatters-880	80	34	,	,	PUNCT
brainmatters-880	80	35	chao	chao	PROPN
brainmatters-880	80	36	,	,	PUNCT
brainmatters-880	80	37	m.	m.	NOUN
brainmatters-880	80	38	v.	v.	PROPN
brainmatters-880	80	39	,	,	PUNCT
brainmatters-880	80	40	mufson	mufson	PROPN
brainmatters-880	80	41	,	,	PUNCT
brainmatters-880	80	42	e.	e.	PROPN
brainmatters-880	80	43	j.	j.	PROPN
brainmatters-880	80	44	,	,	PUNCT
brainmatters-880	80	45	nixon	nixon	PROPN
brainmatters-880	80	46	,	,	PUNCT
brainmatters-880	80	47	r.	r.	PROPN
brainmatters-880	80	48	a.	a.	PROPN
brainmatters-880	80	49	,	,	PUNCT
brainmatters-880	80	50	&	&	CCONJ
brainmatters-880	80	51	che	che	PROPN
brainmatters-880	80	52	,	,	PUNCT
brainmatters-880	80	53	s.	s.	PROPN
brainmatters-880	80	54	(	(	PUNCT
brainmatters-880	80	55	2010	2010	NUM
brainmatters-880	80	56	)	)	PUNCT
brainmatters-880	80	57	.	.	PUNCT
brainmatters-880	81	1	microarray	microarray	VERB
brainmatters-880	81	2	analysis	analysis	NOUN
brainmatters-880	81	3	of	of	ADP
brainmatters-880	81	4	hippocampal	hippocampal	ADJ
brainmatters-880	81	5	ca1	ca1	PROPN
brainmatters-880	81	6	neurons	neuron	NOUN
brainmatters-880	81	7	implicates	implicate	VERB
brainmatters-880	81	8	early	early	ADJ
brainmatters-880	81	9	endosomal	endosomal	ADJ
brainmatters-880	81	10	dysfunction	dysfunction	NOUN
brainmatters-880	81	11	during	during	ADP
brainmatters-880	81	12	alzheimer	alzheimer	PROPN
brainmatters-880	81	13	's	's	PART
brainmatters-880	81	14	disease	disease	NOUN
brainmatters-880	81	15	progression	progression	NOUN
brainmatters-880	81	16	.	.	PUNCT
brainmatters-880	82	1	biological	biological	ADJ
brainmatters-880	82	2	psychiatry	psychiatry	NOUN
brainmatters-880	82	3	,	,	PUNCT
brainmatters-880	82	4	68(10	68(10	NUM
brainmatters-880	82	5	)	)	PUNCT
brainmatters-880	82	6	,	,	PUNCT
brainmatters-880	82	7	885–893	885–893	NUM
brainmatters-880	82	8	.	.	PUNCT
brainmatters-880	83	1	https://doi.org/10.1016/j.biopsych.2010.05.030	https://doi.org/10.1016/j.biopsych.2010.05.030	NOUN
brainmatters-880	83	2	gpcr	gpcr	NOUN
brainmatters-880	83	3	|	|	ADV
brainmatters-880	83	4	learn	learn	VERB
brainmatters-880	83	5	science	science	NOUN
brainmatters-880	83	6	at	at	ADP
brainmatters-880	83	7	scitable	scitable	ADJ
brainmatters-880	83	8	.	.	PUNCT
brainmatters-880	84	1	(	(	PUNCT
brainmatters-880	84	2	n.d	n.d	PROPN
brainmatters-880	84	3	.	.	PROPN
brainmatters-880	84	4	)	)	PUNCT
brainmatters-880	84	5	.	.	PUNCT
brainmatters-880	85	1	scitable	scitable	PROPN
brainmatters-880	85	2	.	.	PUNCT
brainmatters-880	86	1	retrieved	retrieve	VERB
brainmatters-880	86	2	february	february	PROPN
brainmatters-880	86	3	26	26	NUM
brainmatters-880	86	4	,	,	PUNCT
brainmatters-880	86	5	2022	2022	NUM
brainmatters-880	86	6	,	,	PUNCT
brainmatters-880	86	7	from	from	ADP
brainmatters-880	86	8	https://www.nature.com/scitable/topicpage/gpcr14047471/	https://www.nature.com/scitable/topicpage/gpcr14047471/	PROPN
brainmatters-880	86	9	?	?	PUNCT
brainmatters-880	87	1	error	error	NOUN
brainmatters-880	87	2	=	=	NOUN
brainmatters-880	87	3	cookies_not_supported&code=4f65e9e1	cookies_not_supported&code=4f65e9e1	X
brainmatters-880	87	4	-	-	PUNCT
brainmatters-880	87	5	a4a246fa	a4a246fa	VERB
brainmatters-880	87	6	-	-	PUNCT
brainmatters-880	87	7	a388	a388	PROPN
brainmatters-880	87	8	-	-	PUNCT
brainmatters-880	87	9	b0b489fbf9c4	b0b489fbf9c4	PROPN
brainmatters-880	87	10	huang	huang	PROPN
brainmatters-880	87	11	,	,	PUNCT
brainmatters-880	87	12	y.	y.	PROPN
brainmatters-880	87	13	,	,	PUNCT
brainmatters-880	87	14	todd	todd	PROPN
brainmatters-880	87	15	,	,	PUNCT
brainmatters-880	87	16	n.	n.	NOUN
brainmatters-880	87	17	,	,	PUNCT
brainmatters-880	87	18	&	&	CCONJ
brainmatters-880	87	19	thathiah	thathiah	PROPN
brainmatters-880	87	20	,	,	PUNCT
brainmatters-880	87	21	a.	a.	NOUN
brainmatters-880	87	22	(	(	PUNCT
brainmatters-880	87	23	2017	2017	NUM
brainmatters-880	87	24	)	)	PUNCT
brainmatters-880	87	25	.	.	PUNCT
brainmatters-880	88	1	the	the	DET
brainmatters-880	88	2	role	role	NOUN
brainmatters-880	88	3	of	of	ADP
brainmatters-880	88	4	gpcrs	gpcrs	PROPN
brainmatters-880	88	5	in	in	ADP
brainmatters-880	88	6	neurodegenerative	neurodegenerative	ADJ
brainmatters-880	88	7	diseases	disease	NOUN
brainmatters-880	88	8	:	:	PUNCT
brainmatters-880	88	9	avenues	avenue	NOUN
brainmatters-880	88	10	for	for	ADP
brainmatters-880	88	11	therapeutic	therapeutic	ADJ
brainmatters-880	88	12	intervention	intervention	NOUN
brainmatters-880	88	13	.	.	PUNCT
brainmatters-880	89	1	current	current	ADJ
brainmatters-880	89	2	opinion	opinion	NOUN
brainmatters-880	89	3	in	in	ADP
brainmatters-880	89	4	pharmacology	pharmacology	NOUN
brainmatters-880	89	5	,	,	PUNCT
brainmatters-880	89	6	32	32	NUM
brainmatters-880	89	7	,	,	PUNCT
brainmatters-880	89	8	96–110	96–110	PROPN
brainmatters-880	89	9	.	.	PUNCT
brainmatters-880	90	1	https://doi.org/10.1016/j.coph.2017.02.001	https://doi.org/10.1016/j.coph.2017.02.001	PROPN
brainmatters-880	90	2	jiang	jiang	PROPN
brainmatters-880	90	3	,	,	PUNCT
brainmatters-880	90	4	s.	s.	PROPN
brainmatters-880	90	5	,	,	PUNCT
brainmatters-880	90	6	wang	wang	PROPN
brainmatters-880	90	7	,	,	PUNCT
brainmatters-880	90	8	y.	y.	PROPN
brainmatters-880	90	9	,	,	PUNCT
brainmatters-880	90	10	ma	ma	PROPN
brainmatters-880	90	11	,	,	PUNCT
brainmatters-880	90	12	q.	q.	PROPN
brainmatters-880	90	13	,	,	PUNCT
brainmatters-880	90	14	zhou	zhou	PROPN
brainmatters-880	90	15	,	,	PUNCT
brainmatters-880	90	16	a.	a.	PROPN
brainmatters-880	90	17	,	,	PUNCT
brainmatters-880	90	18	zhang	zhang	PROPN
brainmatters-880	90	19	,	,	PUNCT
brainmatters-880	90	20	x.	x.	PROPN
brainmatters-880	90	21	,	,	PUNCT
brainmatters-880	90	22	&	&	CCONJ
brainmatters-880	90	23	zhang	zhang	PROPN
brainmatters-880	90	24	,	,	PUNCT
brainmatters-880	90	25	y.	y.	PROPN
brainmatters-880	90	26	w.	w.	PROPN
brainmatters-880	90	27	(	(	PUNCT
brainmatters-880	90	28	2012	2012	NUM
brainmatters-880	90	29	)	)	PUNCT
brainmatters-880	90	30	.	.	PUNCT
brainmatters-880	91	1	m1	m1	NOUN
brainmatters-880	91	2	muscarinic	muscarinic	ADJ
brainmatters-880	91	3	acetylcholine	acetylcholine	NOUN
brainmatters-880	91	4	receptor	receptor	NOUN
brainmatters-880	91	5	interacts	interact	VERB
brainmatters-880	91	6	with	with	ADP
brainmatters-880	91	7	bace1	bace1	NOUN
brainmatters-880	91	8	and	and	CCONJ
brainmatters-880	91	9	regulates	regulate	VERB
brainmatters-880	91	10	its	its	PRON
brainmatters-880	91	11	proteosomal	proteosomal	ADJ
brainmatters-880	91	12	degradation	degradation	NOUN
brainmatters-880	91	13	.	.	PUNCT
brainmatters-880	92	1	neuroscience	neuroscience	NOUN
brainmatters-880	92	2	letters	letter	NOUN
brainmatters-880	92	3	,	,	PUNCT
brainmatters-880	92	4	515(2	515(2	NUM
brainmatters-880	92	5	)	)	PUNCT
brainmatters-880	92	6	,	,	PUNCT
brainmatters-880	92	7	125–130	125–130	NUM
brainmatters-880	92	8	.	.	PUNCT
brainmatters-880	93	1	https://doi.org/10.1016/j.neulet.2012.03.026	https://doi.org/10.1016/j.neulet.2012.03.026	PROPN
brainmatters-880	93	2	neumann	neumann	PROPN
brainmatters-880	93	3	,	,	PUNCT
brainmatters-880	93	4	e.	e.	PROPN
brainmatters-880	93	5	,	,	PUNCT
brainmatters-880	93	6	khawaja	khawaja	PROPN
brainmatters-880	93	7	,	,	PUNCT
brainmatters-880	93	8	k.	k.	PROPN
brainmatters-880	93	9	,	,	PUNCT
brainmatters-880	93	10	&	&	CCONJ
brainmatters-880	93	11	müller	müller	PROPN
brainmatters-880	93	12	-	-	PUNCT
brainmatters-880	93	13	ladner	ladner	PROPN
brainmatters-880	93	14	,	,	PUNCT
brainmatters-880	93	15	u.	u.	PROPN
brainmatters-880	93	16	(	(	PUNCT
brainmatters-880	93	17	2014	2014	NUM
brainmatters-880	93	18	)	)	PUNCT
brainmatters-880	93	19	.	.	PUNCT
brainmatters-880	94	1	g	g	ADP
brainmatters-880	94	2	protein	protein	NOUN
brainmatters-880	94	3	-	-	PUNCT
brainmatters-880	94	4	coupled	couple	VERB
brainmatters-880	94	5	receptors	receptor	NOUN
brainmatters-880	94	6	in	in	ADP
brainmatters-880	94	7	rheumatology	rheumatology	NOUN
brainmatters-880	94	8	.	.	PUNCT
brainmatters-880	95	1	nature	nature	NOUN
brainmatters-880	95	2	reviews	review	NOUN
brainmatters-880	95	3	.	.	PUNCT
brainmatters-880	96	1	rheumatology	rheumatology	NOUN
brainmatters-880	96	2	,	,	PUNCT
brainmatters-880	96	3	10(7	10(7	NUM
brainmatters-880	96	4	)	)	PUNCT
brainmatters-880	96	5	,	,	PUNCT
brainmatters-880	96	6	429–436	429–436	NUM
brainmatters-880	96	7	.	.	PUNCT
brainmatters-880	97	1	https://doi.org/10.1038/nrrheum.2014.62	https://doi.org/10.1038/nrrheum.2014.62	NOUN
brainmatters-880	97	2	conclusion	conclusion	NOUN
brainmatters-880	97	3	receptors	receptor	NOUN
brainmatters-880	97	4	in	in	ADP
brainmatters-880	97	5	general	general	ADJ
brainmatters-880	97	6	are	be	AUX
brainmatters-880	97	7	vital	vital	ADJ
brainmatters-880	97	8	to	to	ADP
brainmatters-880	97	9	the	the	DET
brainmatters-880	97	10	function	function	NOUN
brainmatters-880	97	11	of	of	ADP
brainmatters-880	97	12	many	many	ADJ
brainmatters-880	97	13	bodily	bodily	ADJ
brainmatters-880	97	14	and	and	CCONJ
brainmatters-880	97	15	brain	brain	NOUN
brainmatters-880	97	16	processes	process	NOUN
brainmatters-880	97	17	.	.	PUNCT
brainmatters-880	98	1	even	even	ADV
brainmatters-880	98	2	more	more	ADV
brainmatters-880	98	3	specifically	specifically	ADV
brainmatters-880	98	4	,	,	PUNCT
brainmatters-880	98	5	gpcrs	gpcrs	PROPN
brainmatters-880	98	6	are	be	AUX
brainmatters-880	98	7	vital	vital	ADJ
brainmatters-880	98	8	to	to	ADP
brainmatters-880	98	9	our	our	PRON
brainmatters-880	98	10	understanding	understanding	NOUN
brainmatters-880	98	11	of	of	ADP
brainmatters-880	98	12	the	the	DET
brainmatters-880	98	13	body	body	NOUN
brainmatters-880	98	14	,	,	PUNCT
brainmatters-880	98	15	as	as	SCONJ
brainmatters-880	98	16	they	they	PRON
brainmatters-880	98	17	make	make	VERB
brainmatters-880	98	18	up	up	ADP
brainmatters-880	98	19	a	a	DET
brainmatters-880	98	20	large	large	ADJ
brainmatters-880	98	21	chunk	chunk	NOUN
brainmatters-880	98	22	of	of	ADP
brainmatters-880	98	23	all	all	DET
brainmatters-880	98	24	receptors	receptor	NOUN
brainmatters-880	98	25	,	,	PUNCT
brainmatters-880	98	26	especially	especially	ADV
brainmatters-880	98	27	in	in	ADP
brainmatters-880	98	28	the	the	DET
brainmatters-880	98	29	brain	brain	NOUN
brainmatters-880	98	30	.	.	PUNCT
brainmatters-880	99	1	further	further	ADJ
brainmatters-880	99	2	research	research	NOUN
brainmatters-880	99	3	into	into	ADP
brainmatters-880	99	4	the	the	DET
brainmatters-880	99	5	functions	function	NOUN
brainmatters-880	99	6	of	of	ADP
brainmatters-880	99	7	gpcrs	gpcrs	PROPN
brainmatters-880	99	8	and	and	CCONJ
brainmatters-880	99	9	gpcr	gpcr	ADJ
brainmatters-880	99	10	signal	signal	NOUN
brainmatters-880	99	11	transduction	transduction	NOUN
brainmatters-880	99	12	pathways	pathway	NOUN
brainmatters-880	99	13	in	in	ADP
brainmatters-880	99	14	relation	relation	NOUN
brainmatters-880	99	15	to	to	ADP
brainmatters-880	99	16	bace1	bace1	NOUN
brainmatters-880	99	17	and	and	CCONJ
brainmatters-880	99	18	other	other	ADJ
brainmatters-880	99	19	enzymes	enzyme	NOUN
brainmatters-880	99	20	would	would	AUX
brainmatters-880	99	21	open	open	VERB
brainmatters-880	99	22	the	the	DET
brainmatters-880	99	23	door	door	NOUN
brainmatters-880	99	24	,	,	PUNCT
brainmatters-880	99	25	not	not	PART
brainmatters-880	99	26	only	only	ADV
brainmatters-880	99	27	to	to	ADP
brainmatters-880	99	28	potential	potential	ADJ
brainmatters-880	99	29	treatments	treatment	NOUN
brainmatters-880	99	30	and	and	CCONJ
brainmatters-880	99	31	maybe	maybe	ADV
brainmatters-880	99	32	even	even	ADV
brainmatters-880	99	33	a	a	DET
brainmatters-880	99	34	cure	cure	NOUN
brainmatters-880	99	35	for	for	ADP
brainmatters-880	99	36	alzheimer	alzheimer	PROPN
brainmatters-880	99	37	’s	’s	PART
brainmatters-880	99	38	,	,	PUNCT
brainmatters-880	99	39	but	but	CCONJ
brainmatters-880	99	40	also	also	ADV
brainmatters-880	99	41	to	to	ADP
brainmatters-880	99	42	several	several	ADJ
brainmatters-880	99	43	treatments	treatment	NOUN
brainmatters-880	99	44	for	for	ADP
brainmatters-880	99	45	cns	cns	NOUN
brainmatters-880	99	46	disorders	disorder	NOUN
brainmatters-880	99	47	such	such	ADJ
brainmatters-880	99	48	as	as	ADP
brainmatters-880	99	49	parkinson	parkinson	NOUN
brainmatters-880	99	50	’s	’s	PART
brainmatters-880	99	51	and	and	CCONJ
brainmatters-880	99	52	huntington	huntington	PROPN
brainmatters-880	99	53	’s	’s	PART
brainmatters-880	99	54	disease	disease	NOUN
brainmatters-880	99	55	.	.	PUNCT
brainmatters-880	100	1	therefore	therefore	ADV
brainmatters-880	100	2	,	,	PUNCT
brainmatters-880	100	3	a	a	DET
brainmatters-880	100	4	partial	partial	ADJ
brainmatters-880	100	5	,	,	PUNCT
brainmatters-880	100	6	rather	rather	ADV
brainmatters-880	100	7	than	than	ADP
brainmatters-880	100	8	full	full	ADJ
brainmatters-880	100	9	,	,	PUNCT
brainmatters-880	100	10	inhibition	inhibition	NOUN
brainmatters-880	100	11	of	of	ADP
brainmatters-880	100	12	this	this	DET
brainmatters-880	100	13	enzymatic	enzymatic	ADJ
brainmatters-880	100	14	activity	activity	NOUN
brainmatters-880	100	15	may	may	AUX
brainmatters-880	100	16	be	be	AUX
brainmatters-880	100	17	beneficial	beneficial	ADJ
brainmatters-880	100	18	,	,	PUNCT
brainmatters-880	100	19	although	although	SCONJ
brainmatters-880	100	20	the	the	DET
brainmatters-880	100	21	percentage	percentage	NOUN
brainmatters-880	100	22	of	of	ADP
brainmatters-880	100	23	bace1	bace1	NOUN
brainmatters-880	100	24	inhibition	inhibition	NOUN
brainmatters-880	100	25	required	require	VERB
brainmatters-880	100	26	to	to	PART
brainmatters-880	100	27	significantly	significantly	ADV
brainmatters-880	100	28	delay	delay	VERB
brainmatters-880	100	29	amyloid	amyloid	NOUN
brainmatters-880	100	30	pathology	pathology	NOUN
brainmatters-880	100	31	and	and	CCONJ
brainmatters-880	100	32	the	the	DET
brainmatters-880	100	33	associated	associated	ADJ
brainmatters-880	100	34	cognitive	cognitive	ADJ
brainmatters-880	100	35	changes	change	NOUN
brainmatters-880	100	36	,	,	PUNCT
brainmatters-880	100	37	remains	remain	VERB
brainmatters-880	100	38	to	to	PART
brainmatters-880	100	39	be	be	AUX
brainmatters-880	100	40	determined	determine	VERB
brainmatters-880	100	41	.	.	PUNCT
brainmatters-880	101	1	references	reference	NOUN
brainmatters-880	101	2	1	1	NUM
brainmatters-880	101	3	.	.	NOUN
brainmatters-880	101	4	2	2	NUM
brainmatters-880	101	5	.	.	NOUN
brainmatters-880	101	6	3	3	NUM
brainmatters-880	101	7	.	.	NOUN
brainmatters-880	101	8	4	4	NUM
brainmatters-880	101	9	.	.	NOUN
brainmatters-880	101	10	5	5	NUM
brainmatters-880	101	11	.	.	NOUN
brainmatters-880	101	12	6	6	NUM
brainmatters-880	101	13	.	.	NOUN
brainmatters-880	101	14	7	7	NUM
brainmatters-880	101	15	.	.	NOUN
brainmatters-880	101	16	8	8	NUM
brainmatters-880	101	17	.	.	NOUN
brainmatters-880	101	18	9	9	NUM
brainmatters-880	101	19	.	.	X
brainmatters-880	101	20	10	10	NUM
brainmatters-880	101	21	.	.	PUNCT
brainmatters-880	102	1	tuteja	tuteja	VERB
brainmatters-880	102	2	n.	n.	NOUN
brainmatters-880	102	3	(	(	PUNCT
brainmatters-880	102	4	2009	2009	NUM
brainmatters-880	102	5	)	)	PUNCT
brainmatters-880	102	6	.	.	PUNCT
brainmatters-880	103	1	signaling	signal	VERB
brainmatters-880	103	2	through	through	ADP
brainmatters-880	103	3	g	g	NOUN
brainmatters-880	103	4	protein	protein	NOUN
brainmatters-880	103	5	coupled	couple	VERB
brainmatters-880	103	6	receptors	receptor	NOUN
brainmatters-880	103	7	.	.	PUNCT
brainmatters-880	104	1	plant	plant	NOUN
brainmatters-880	104	2	signaling	signaling	NOUN
brainmatters-880	104	3	&	&	CCONJ
brainmatters-880	104	4	behavior	behavior	PROPN
brainmatters-880	104	5	,	,	PUNCT
brainmatters-880	104	6	4(10	4(10	NUM
brainmatters-880	104	7	)	)	PUNCT
brainmatters-880	104	8	,	,	PUNCT
brainmatters-880	104	9	942–947	942–947	NUM
brainmatters-880	104	10	.	.	PUNCT
brainmatters-880	105	1	https://doi.org/10.4161/psb.4.10.9530	https://doi.org/10.4161/psb.4.10.9530	PROPN
brainmatters-880	105	2	zhao	zhao	PROPN
brainmatters-880	105	3	,	,	PUNCT
brainmatters-880	105	4	j.	j.	PROPN
brainmatters-880	105	5	,	,	PUNCT
brainmatters-880	105	6	deng	deng	PROPN
brainmatters-880	105	7	,	,	PUNCT
brainmatters-880	105	8	y.	y.	PROPN
brainmatters-880	105	9	,	,	PUNCT
brainmatters-880	105	10	jiang	jiang	PROPN
brainmatters-880	105	11	,	,	PUNCT
brainmatters-880	105	12	z.	z.	PROPN
brainmatters-880	105	13	,	,	PUNCT
brainmatters-880	105	14	&	&	CCONJ
brainmatters-880	105	15	qing	qing	PROPN
brainmatters-880	105	16	,	,	PUNCT
brainmatters-880	105	17	h.	h.	PROPN
brainmatters-880	105	18	(	(	PUNCT
brainmatters-880	105	19	2016	2016	NUM
brainmatters-880	105	20	)	)	PUNCT
brainmatters-880	105	21	.	.	PUNCT
brainmatters-880	106	1	g	g	ADP
brainmatters-880	106	2	protein	protein	NOUN
brainmatters-880	106	3	-	-	PUNCT
brainmatters-880	106	4	coupled	couple	VERB
brainmatters-880	106	5	receptors	receptor	NOUN
brainmatters-880	106	6	(	(	PUNCT
brainmatters-880	106	7	gpcrs	gpcrs	PROPN
brainmatters-880	106	8	)	)	PUNCT
brainmatters-880	106	9	in	in	ADP
brainmatters-880	106	10	alzheimer	alzheimer	PROPN
brainmatters-880	106	11	's	's	PART
brainmatters-880	106	12	disease	disease	NOUN
brainmatters-880	106	13	:	:	PUNCT
brainmatters-880	106	14	a	a	DET
brainmatters-880	106	15	focus	focus	NOUN
brainmatters-880	106	16	on	on	ADP
brainmatters-880	106	17	bace1	bace1	NOUN
brainmatters-880	106	18	related	relate	VERB
brainmatters-880	106	19	gpcrs	gpcrs	PROPN
brainmatters-880	106	20	.	.	PUNCT
brainmatters-880	107	1	frontiers	frontier	NOUN
brainmatters-880	107	2	in	in	ADP
brainmatters-880	107	3	aging	age	VERB
brainmatters-880	107	4	neuroscience	neuroscience	NOUN
brainmatters-880	107	5	,	,	PUNCT
brainmatters-880	107	6	8	8	NUM
brainmatters-880	107	7	,	,	PUNCT
brainmatters-880	107	8	58	58	NUM
brainmatters-880	107	9	.	.	PUNCT
brainmatters-880	108	1	https://doi.org/10.3389/fnagi.2016.00058	https://doi.org/10.3389/fnagi.2016.00058	PROPN
brainmatters-880	108	2	6brain	6brain	PROPN
brainmatters-880	108	3	matters	matter	VERB
brainmatters-880	108	4	volume	volume	NOUN
brainmatters-880	108	5	vi	vi	PROPN
brainmatters-880	108	6	https://doi.org/10.3390/cells9020506	https://doi.org/10.3390/cells9020506	NOUN
brainmatters-880	108	7	https://doi.org/10.1016/j.biopsych.2010.05.030	https://doi.org/10.1016/j.biopsych.2010.05.030	NOUN
brainmatters-880	108	8	https://www.nature.com/scitable/topicpage/gpcr-14047471/?error=cookies_not_supported&code=4f65e9e1-a4a2-46fa-a388-b0b489fbf9c4	https://www.nature.com/scitable/topicpage/gpcr-14047471/?error=cookies_not_supported&code=4f65e9e1-a4a2-46fa-a388-b0b489fbf9c4	NOUN
brainmatters-880	108	9	https://doi.org/10.1016/j.coph.2017.02.001	https://doi.org/10.1016/j.coph.2017.02.001	VERB
brainmatters-880	108	10	https://doi.org/10.1016/j.neulet.2012.03.026	https://doi.org/10.1016/j.neulet.2012.03.026	PROPN
brainmatters-880	108	11	https://doi.org/10.1038/nrrheum.2014.62	https://doi.org/10.1038/nrrheum.2014.62	PROPN
brainmatters-880	108	12	https://doi.org/10.4161/psb.4.10.9530	https://doi.org/10.4161/psb.4.10.9530	PROPN
brainmatters-880	108	13	https://doi.org/10.3389/fnagi.2016.00058	https://doi.org/10.3389/fnagi.2016.00058	PROPN