id	sid	tid	token	lemma	pos
brainmatters-882	1	1	copy	copy	NOUN
brainmatters-882	1	2	of	of	ADP
brainmatters-882	1	3	volume	volume	NOUN
brainmatters-882	1	4	6	6	NUM
brainmatters-882	1	5	publication	publication	NOUN
brainmatters-882	1	6	can	can	AUX
brainmatters-882	1	7	gene	gene	VERB
brainmatters-882	1	8	editing	editing	NOUN
brainmatters-882	1	9	be	be	AUX
brainmatters-882	1	10	the	the	DET
brainmatters-882	1	11	key	key	NOUN
brainmatters-882	1	12	to	to	ADP
brainmatters-882	1	13	treating	treat	VERB
brainmatters-882	1	14	alzheimers	alzheimer	NOUN
brainmatters-882	1	15	?	?	PUNCT
brainmatters-882	2	1	saani	saani	PROPN
brainmatters-882	2	2	kulkarni	kulkarni	PROPN
brainmatters-882	2	3	commonly	commonly	ADV
brainmatters-882	2	4	known	know	VERB
brainmatters-882	2	5	as	as	ADP
brainmatters-882	2	6	the	the	DET
brainmatters-882	2	7	most	most	ADV
brainmatters-882	2	8	complex	complex	ADJ
brainmatters-882	2	9	part	part	NOUN
brainmatters-882	2	10	of	of	ADP
brainmatters-882	2	11	the	the	DET
brainmatters-882	2	12	human	human	ADJ
brainmatters-882	2	13	body	body	NOUN
brainmatters-882	2	14	,	,	PUNCT
brainmatters-882	2	15	the	the	DET
brainmatters-882	2	16	brain	brain	NOUN
brainmatters-882	2	17	contains	contain	VERB
brainmatters-882	2	18	millions	million	NOUN
brainmatters-882	2	19	of	of	ADP
brainmatters-882	2	20	neurons	neuron	NOUN
brainmatters-882	2	21	,	,	PUNCT
brainmatters-882	2	22	each	each	PRON
brainmatters-882	2	23	with	with	ADP
brainmatters-882	2	24	the	the	DET
brainmatters-882	2	25	ability	ability	NOUN
brainmatters-882	2	26	to	to	PART
brainmatters-882	2	27	send	send	VERB
brainmatters-882	2	28	and	and	CCONJ
brainmatters-882	2	29	receive	receive	VERB
brainmatters-882	2	30	unique	unique	ADJ
brainmatters-882	2	31	messages	message	NOUN
brainmatters-882	2	32	utilizing	utilize	VERB
brainmatters-882	2	33	electrochemical	electrochemical	ADJ
brainmatters-882	2	34	signals	signal	NOUN
brainmatters-882	2	35	.	.	PUNCT
brainmatters-882	3	1	however	however	ADV
brainmatters-882	3	2	,	,	PUNCT
brainmatters-882	3	3	in	in	ADP
brainmatters-882	3	4	individuals	individual	NOUN
brainmatters-882	3	5	with	with	ADP
brainmatters-882	3	6	alzheimers	alzheimer	NOUN
brainmatters-882	3	7	and	and	CCONJ
brainmatters-882	3	8	other	other	ADJ
brainmatters-882	3	9	neurodegenerative	neurodegenerative	ADJ
brainmatters-882	3	10	diseases	disease	NOUN
brainmatters-882	3	11	,	,	PUNCT
brainmatters-882	3	12	the	the	DET
brainmatters-882	3	13	typical	typical	ADJ
brainmatters-882	3	14	function	function	NOUN
brainmatters-882	3	15	of	of	ADP
brainmatters-882	3	16	neurons	neuron	NOUN
brainmatters-882	3	17	is	be	AUX
brainmatters-882	3	18	impaired	impair	VERB
brainmatters-882	3	19	greatly	greatly	ADV
brainmatters-882	3	20	.	.	PUNCT
brainmatters-882	4	1	the	the	DET
brainmatters-882	4	2	lifespan	lifespan	NOUN
brainmatters-882	4	3	of	of	ADP
brainmatters-882	4	4	a	a	DET
brainmatters-882	4	5	neuron	neuron	NOUN
brainmatters-882	4	6	is	be	AUX
brainmatters-882	4	7	dependent	dependent	ADJ
brainmatters-882	4	8	upon	upon	SCONJ
brainmatters-882	4	9	3	3	NUM
brainmatters-882	4	10	primary	primary	ADJ
brainmatters-882	4	11	factors	factor	NOUN
brainmatters-882	4	12	:	:	PUNCT
brainmatters-882	4	13	communication	communication	NOUN
brainmatters-882	4	14	,	,	PUNCT
brainmatters-882	4	15	metabolism	metabolism	NOUN
brainmatters-882	4	16	,	,	PUNCT
brainmatters-882	4	17	and	and	CCONJ
brainmatters-882	4	18	its	its	PRON
brainmatters-882	4	19	ability	ability	NOUN
brainmatters-882	4	20	to	to	PART
brainmatters-882	4	21	repair	repair	VERB
brainmatters-882	4	22	itself	itself	PRON
brainmatters-882	4	23	.	.	PUNCT
brainmatters-882	5	1	without	without	ADP
brainmatters-882	5	2	proper	proper	ADJ
brainmatters-882	5	3	signaling	signaling	NOUN
brainmatters-882	5	4	,	,	PUNCT
brainmatters-882	5	5	neurons	neuron	NOUN
brainmatters-882	5	6	are	be	AUX
brainmatters-882	5	7	unable	unable	ADJ
brainmatters-882	5	8	to	to	PART
brainmatters-882	5	9	access	access	VERB
brainmatters-882	5	10	their	their	PRON
brainmatters-882	5	11	target	target	NOUN
brainmatters-882	5	12	cells	cell	NOUN
brainmatters-882	5	13	and	and	CCONJ
brainmatters-882	5	14	gain	gain	VERB
brainmatters-882	5	15	access	access	NOUN
brainmatters-882	5	16	to	to	ADP
brainmatters-882	5	17	necessary	necessary	ADJ
brainmatters-882	5	18	trophic	trophic	ADJ
brainmatters-882	5	19	factors	factor	NOUN
brainmatters-882	5	20	.	.	PUNCT
brainmatters-882	6	1	moreover	moreover	ADV
brainmatters-882	6	2	,	,	PUNCT
brainmatters-882	6	3	neurons	neuron	NOUN
brainmatters-882	6	4	require	require	VERB
brainmatters-882	6	5	adequate	adequate	ADJ
brainmatters-882	6	6	nutrients	nutrient	NOUN
brainmatters-882	6	7	and	and	CCONJ
brainmatters-882	6	8	chemicals	chemical	NOUN
brainmatters-882	6	9	to	to	PART
brainmatters-882	6	10	operate	operate	VERB
brainmatters-882	6	11	,	,	PUNCT
brainmatters-882	6	12	gaining	gain	VERB
brainmatters-882	6	13	their	their	PRON
brainmatters-882	6	14	energy	energy	NOUN
brainmatters-882	6	15	through	through	ADP
brainmatters-882	6	16	oxygen	oxygen	NOUN
brainmatters-882	6	17	and	and	CCONJ
brainmatters-882	6	18	glucose	glucose	NOUN
brainmatters-882	6	19	from	from	ADP
brainmatters-882	6	20	the	the	DET
brainmatters-882	6	21	blood	blood	NOUN
brainmatters-882	6	22	;	;	PUNCT
brainmatters-882	6	23	the	the	DET
brainmatters-882	6	24	lack	lack	NOUN
brainmatters-882	6	25	of	of	ADP
brainmatters-882	6	26	these	these	DET
brainmatters-882	6	27	necessities	necessity	NOUN
brainmatters-882	6	28	will	will	AUX
brainmatters-882	6	29	result	result	VERB
brainmatters-882	6	30	in	in	ADP
brainmatters-882	6	31	the	the	DET
brainmatters-882	6	32	death	death	NOUN
brainmatters-882	6	33	of	of	ADP
brainmatters-882	6	34	the	the	DET
brainmatters-882	6	35	neuron	neuron	NOUN
brainmatters-882	6	36	.	.	PUNCT
brainmatters-882	7	1	they	they	PRON
brainmatters-882	7	2	must	must	AUX
brainmatters-882	7	3	also	also	ADV
brainmatters-882	7	4	be	be	AUX
brainmatters-882	7	5	able	able	ADJ
brainmatters-882	7	6	to	to	PART
brainmatters-882	7	7	maintain	maintain	VERB
brainmatters-882	7	8	a	a	DET
brainmatters-882	7	9	healthy	healthy	ADJ
brainmatters-882	7	10	state	state	NOUN
brainmatters-882	7	11	throughout	throughout	ADP
brainmatters-882	7	12	their	their	PRON
brainmatters-882	7	13	lifespan	lifespan	NOUN
brainmatters-882	7	14	;	;	PUNCT
brainmatters-882	7	15	while	while	SCONJ
brainmatters-882	7	16	other	other	ADJ
brainmatters-882	7	17	human	human	ADJ
brainmatters-882	7	18	body	body	NOUN
brainmatters-882	7	19	cells	cell	NOUN
brainmatters-882	7	20	may	may	AUX
brainmatters-882	7	21	die	die	VERB
brainmatters-882	7	22	quickly	quickly	ADV
brainmatters-882	7	23	,	,	PUNCT
brainmatters-882	7	24	neurons	neuron	NOUN
brainmatters-882	7	25	are	be	AUX
brainmatters-882	7	26	observed	observe	VERB
brainmatters-882	7	27	to	to	PART
brainmatters-882	7	28	be	be	AUX
brainmatters-882	7	29	able	able	ADJ
brainmatters-882	7	30	to	to	PART
brainmatters-882	7	31	live	live	VERB
brainmatters-882	7	32	beyond	beyond	ADP
brainmatters-882	7	33	100	100	NUM
brainmatters-882	7	34	years	year	NOUN
brainmatters-882	7	35	of	of	ADP
brainmatters-882	7	36	age	age	NOUN
brainmatters-882	7	37	in	in	ADP
brainmatters-882	7	38	the	the	DET
brainmatters-882	7	39	human	human	ADJ
brainmatters-882	7	40	body	body	NOUN
brainmatters-882	7	41	.	.	PUNCT
brainmatters-882	8	1	while	while	SCONJ
brainmatters-882	8	2	in	in	ADP
brainmatters-882	8	3	a	a	DET
brainmatters-882	8	4	healthy	healthy	ADJ
brainmatters-882	8	5	human	human	ADJ
brainmatters-882	8	6	brain	brain	NOUN
brainmatters-882	8	7	neurons	neuron	NOUN
brainmatters-882	8	8	may	may	AUX
brainmatters-882	8	9	possess	possess	VERB
brainmatters-882	8	10	all	all	DET
brainmatters-882	8	11	these	these	DET
brainmatters-882	8	12	qualities	quality	NOUN
brainmatters-882	8	13	,	,	PUNCT
brainmatters-882	8	14	the	the	DET
brainmatters-882	8	15	opposite	opposite	NOUN
brainmatters-882	8	16	can	can	AUX
brainmatters-882	8	17	be	be	AUX
brainmatters-882	8	18	said	say	VERB
brainmatters-882	8	19	for	for	ADP
brainmatters-882	8	20	the	the	DET
brainmatters-882	8	21	brain	brain	NOUN
brainmatters-882	8	22	in	in	ADP
brainmatters-882	8	23	regards	regard	NOUN
brainmatters-882	8	24	to	to	ADP
brainmatters-882	8	25	alzheimers	alzheimer	NOUN
brainmatters-882	8	26	;	;	PUNCT
brainmatters-882	8	27	eventually	eventually	ADV
brainmatters-882	8	28	,	,	PUNCT
brainmatters-882	8	29	many	many	ADJ
brainmatters-882	8	30	neurons	neuron	NOUN
brainmatters-882	8	31	stop	stop	VERB
brainmatters-882	8	32	functioning	function	VERB
brainmatters-882	8	33	and	and	CCONJ
brainmatters-882	8	34	die	die	VERB
brainmatters-882	8	35	out	out	ADP
brainmatters-882	8	36	.	.	PUNCT
brainmatters-882	9	1	due	due	ADP
brainmatters-882	9	2	to	to	ADP
brainmatters-882	9	3	this	this	PRON
brainmatters-882	9	4	,	,	PUNCT
brainmatters-882	9	5	essential	essential	ADJ
brainmatters-882	9	6	connections	connection	NOUN
brainmatters-882	9	7	at	at	ADP
brainmatters-882	9	8	the	the	DET
brainmatters-882	9	9	synapse	synapse	NOUN
brainmatters-882	9	10	may	may	AUX
brainmatters-882	9	11	be	be	AUX
brainmatters-882	9	12	broken	break	VERB
brainmatters-882	9	13	down	down	ADP
brainmatters-882	9	14	,	,	PUNCT
brainmatters-882	9	15	impairing	impair	VERB
brainmatters-882	9	16	an	an	DET
brainmatters-882	9	17	individual	individual	NOUN
brainmatters-882	9	18	from	from	ADP
brainmatters-882	9	19	receiving	receive	VERB
brainmatters-882	9	20	necessary	necessary	ADJ
brainmatters-882	9	21	signals	signal	NOUN
brainmatters-882	9	22	to	to	PART
brainmatters-882	9	23	carry	carry	VERB
brainmatters-882	9	24	out	out	ADP
brainmatters-882	9	25	tasks	task	NOUN
brainmatters-882	9	26	.	.	PUNCT
brainmatters-882	10	1	while	while	SCONJ
brainmatters-882	10	2	researchers	researcher	NOUN
brainmatters-882	10	3	continue	continue	VERB
brainmatters-882	10	4	to	to	PART
brainmatters-882	10	5	investigate	investigate	VERB
brainmatters-882	10	6	all	all	DET
brainmatters-882	10	7	causes	cause	NOUN
brainmatters-882	10	8	behind	behind	ADP
brainmatters-882	10	9	alzheimers	alzheimer	NOUN
brainmatters-882	10	10	,	,	PUNCT
brainmatters-882	10	11	the	the	DET
brainmatters-882	10	12	beta	beta	NOUN
brainmatters-882	10	13	-	-	PUNCT
brainmatters-882	10	14	amyloid	amyloid	NOUN
brainmatters-882	10	15	protein	protein	NOUN
brainmatters-882	10	16	is	be	AUX
brainmatters-882	10	17	commonly	commonly	ADV
brainmatters-882	10	18	known	know	VERB
brainmatters-882	10	19	as	as	ADP
brainmatters-882	10	20	a	a	DET
brainmatters-882	10	21	major	major	ADJ
brainmatters-882	10	22	factor	factor	NOUN
brainmatters-882	10	23	in	in	ADP
brainmatters-882	10	24	the	the	DET
brainmatters-882	10	25	development	development	NOUN
brainmatters-882	10	26	of	of	ADP
brainmatters-882	10	27	the	the	DET
brainmatters-882	10	28	disease	disease	NOUN
brainmatters-882	10	29	.	.	PUNCT
brainmatters-882	11	1	the	the	DET
brainmatters-882	11	2	cause	cause	NOUN
brainmatters-882	11	3	of	of	ADP
brainmatters-882	11	4	the	the	DET
brainmatters-882	11	5	cleavage	cleavage	NOUN
brainmatters-882	11	6	of	of	ADP
brainmatters-882	11	7	the	the	DET
brainmatters-882	11	8	amyloid	amyloid	NOUN
brainmatters-882	11	9	precursor	precursor	NOUN
brainmatters-882	11	10	protein	protein	NOUN
brainmatters-882	11	11	(	(	PUNCT
brainmatters-882	11	12	app	app	PROPN
brainmatters-882	11	13	)	)	PUNCT
brainmatters-882	11	14	,	,	PUNCT
brainmatters-882	11	15	the	the	DET
brainmatters-882	11	16	presence	presence	NOUN
brainmatters-882	11	17	of	of	ADP
brainmatters-882	11	18	the	the	DET
brainmatters-882	11	19	beta	beta	NOUN
brainmatters-882	11	20	-	-	PUNCT
brainmatters-882	11	21	amyloid	amyloid	NOUN
brainmatters-882	11	22	protein	protein	NOUN
brainmatters-882	11	23	is	be	AUX
brainmatters-882	11	24	originally	originally	ADV
brainmatters-882	11	25	beneficial	beneficial	ADJ
brainmatters-882	11	26	,	,	PUNCT
brainmatters-882	11	27	as	as	SCONJ
brainmatters-882	11	28	it	it	PRON
brainmatters-882	11	29	plays	play	VERB
brainmatters-882	11	30	a	a	DET
brainmatters-882	11	31	significant	significant	ADJ
brainmatters-882	11	32	part	part	NOUN
brainmatters-882	11	33	in	in	ADP
brainmatters-882	11	34	neural	neural	ADJ
brainmatters-882	11	35	growth	growth	NOUN
brainmatters-882	11	36	and	and	CCONJ
brainmatters-882	11	37	neural	neural	ADJ
brainmatters-882	11	38	repair	repair	NOUN
brainmatters-882	11	39	.	.	PUNCT
brainmatters-882	12	1	however	however	ADV
brainmatters-882	12	2	,	,	PUNCT
brainmatters-882	12	3	a	a	DET
brainmatters-882	12	4	form	form	NOUN
brainmatters-882	12	5	of	of	ADP
brainmatters-882	12	6	beta	beta	NOUN
brainmatters-882	12	7	-	-	PUNCT
brainmatters-882	12	8	amyloid	amyloid	NOUN
brainmatters-882	12	9	known	know	VERB
brainmatters-882	12	10	as	as	ADP
brainmatters-882	12	11	betaamyloid	betaamyloid	PROPN
brainmatters-882	12	12	peptide	peptide	NOUN
brainmatters-882	12	13	42	42	NUM
brainmatters-882	12	14	has	have	AUX
brainmatters-882	12	15	been	be	AUX
brainmatters-882	12	16	proven	prove	VERB
brainmatters-882	12	17	to	to	PART
brainmatters-882	12	18	be	be	AUX
brainmatters-882	12	19	significantly	significantly	ADV
brainmatters-882	12	20	toxic	toxic	ADJ
brainmatters-882	12	21	to	to	ADP
brainmatters-882	12	22	the	the	DET
brainmatters-882	12	23	human	human	ADJ
brainmatters-882	12	24	body	body	NOUN
brainmatters-882	12	25	.	.	PUNCT
brainmatters-882	13	1	almost	almost	ADV
brainmatters-882	13	2	plaque	plaque	NOUN
brainmatters-882	13	3	-	-	PUNCT
brainmatters-882	13	4	like	like	ADJ
brainmatters-882	13	5	,	,	PUNCT
brainmatters-882	13	6	beta	beta	NOUN
brainmatters-882	13	7	-	-	PUNCT
brainmatters-882	13	8	amyloid	amyloid	NOUN
brainmatters-882	13	9	42	42	NUM
brainmatters-882	13	10	begins	begin	VERB
brainmatters-882	13	11	to	to	PART
brainmatters-882	13	12	gather	gather	VERB
brainmatters-882	13	13	in	in	ADP
brainmatters-882	13	14	large	large	ADJ
brainmatters-882	13	15	quantities	quantity	NOUN
brainmatters-882	13	16	between	between	ADP
brainmatters-882	13	17	neurons	neuron	NOUN
brainmatters-882	13	18	,	,	PUNCT
brainmatters-882	13	19	damaging	damage	VERB
brainmatters-882	13	20	their	their	PRON
brainmatters-882	13	21	functioning	functioning	NOUN
brainmatters-882	13	22	and	and	CCONJ
brainmatters-882	13	23	breaking	break	VERB
brainmatters-882	13	24	down	down	ADP
brainmatters-882	13	25	their	their	PRON
brainmatters-882	13	26	connections	connection	NOUN
brainmatters-882	13	27	.	.	PUNCT
brainmatters-882	14	1	alongside	alongside	ADP
brainmatters-882	14	2	b	b	X
brainmatters-882	14	3	-	-	PUNCT
brainmatters-882	14	4	amyloid	amyloid	NOUN
brainmatters-882	14	5	42	42	NUM
brainmatters-882	14	6	,	,	PUNCT
brainmatters-882	14	7	a	a	DET
brainmatters-882	14	8	protein	protein	NOUN
brainmatters-882	14	9	known	know	VERB
brainmatters-882	14	10	by	by	ADP
brainmatters-882	14	11	tau	tau	PROPN
brainmatters-882	14	12	that	that	SCONJ
brainmatters-882	14	13	functions	function	NOUN
brainmatters-882	14	14	as	as	ADP
brainmatters-882	14	15	a	a	DET
brainmatters-882	14	16	stabilizer	stabilizer	NOUN
brainmatters-882	14	17	for	for	ADP
brainmatters-882	14	18	microtubules	microtubule	NOUN
brainmatters-882	14	19	by	by	ADP
brainmatters-882	14	20	attaching	attach	VERB
brainmatters-882	14	21	to	to	ADP
brainmatters-882	14	22	them	they	PRON
brainmatters-882	14	23	is	be	AUX
brainmatters-882	14	24	often	often	ADV
brainmatters-882	14	25	found	find	VERB
brainmatters-882	14	26	in	in	ADP
brainmatters-882	14	27	the	the	DET
brainmatters-882	14	28	human	human	ADJ
brainmatters-882	14	29	body	body	NOUN
brainmatters-882	14	30	as	as	ADV
brainmatters-882	14	31	well	well	ADV
brainmatters-882	14	32	.	.	PUNCT
brainmatters-882	15	1	however	however	ADV
brainmatters-882	15	2	,	,	PUNCT
brainmatters-882	15	3	tau	tau	PROPN
brainmatters-882	15	4	can	can	AUX
brainmatters-882	15	5	separate	separate	VERB
brainmatters-882	15	6	and	and	CCONJ
brainmatters-882	15	7	connects	connect	VERB
brainmatters-882	15	8	to	to	ADP
brainmatters-882	15	9	other	other	ADJ
brainmatters-882	15	10	tau	tau	PROPN
brainmatters-882	15	11	molecules	molecule	NOUN
brainmatters-882	15	12	instead	instead	ADV
brainmatters-882	15	13	,	,	PUNCT
brainmatters-882	15	14	creating	create	VERB
brainmatters-882	15	15	numerous	numerous	ADJ
brainmatters-882	15	16	knots	knot	NOUN
brainmatters-882	15	17	and	and	CCONJ
brainmatters-882	15	18	disruptions	disruption	NOUN
brainmatters-882	15	19	inside	inside	ADP
brainmatters-882	15	20	the	the	DET
brainmatters-882	15	21	neuron	neuron	NOUN
brainmatters-882	15	22	and	and	CCONJ
brainmatters-882	15	23	ultimately	ultimately	ADV
brainmatters-882	15	24	affecting	affect	VERB
brainmatters-882	15	25	their	their	PRON
brainmatters-882	15	26	ability	ability	NOUN
brainmatters-882	15	27	to	to	PART
brainmatters-882	15	28	communicate	communicate	VERB
brainmatters-882	15	29	.	.	PUNCT
brainmatters-882	16	1	researchers	researcher	NOUN
brainmatters-882	16	2	have	have	AUX
brainmatters-882	16	3	found	find	VERB
brainmatters-882	16	4	a	a	DET
brainmatters-882	16	5	positive	positive	ADJ
brainmatters-882	16	6	correlation	correlation	NOUN
brainmatters-882	16	7	between	between	ADP
brainmatters-882	16	8	an	an	DET
brainmatters-882	16	9	increased	increase	VERB
brainmatters-882	16	10	presence	presence	NOUN
brainmatters-882	16	11	of	of	ADP
brainmatters-882	16	12	tau	tau	PROPN
brainmatters-882	16	13	and	and	CCONJ
brainmatters-882	16	14	that	that	PRON
brainmatters-882	16	15	of	of	ADP
brainmatters-882	16	16	beta	beta	NOUN
brainmatters-882	16	17	-	-	PUNCT
brainmatters-882	16	18	amyloid	amyloid	NOUN
brainmatters-882	16	19	,	,	PUNCT
brainmatters-882	16	20	hinting	hint	VERB
brainmatters-882	16	21	at	at	ADP
brainmatters-882	16	22	the	the	DET
brainmatters-882	16	23	fact	fact	NOUN
brainmatters-882	16	24	that	that	SCONJ
brainmatters-882	16	25	there	there	PRON
brainmatters-882	16	26	are	be	VERB
brainmatters-882	16	27	multiple	multiple	ADJ
brainmatters-882	16	28	mechanisms	mechanism	NOUN
brainmatters-882	16	29	intertwined	intertwine	VERB
brainmatters-882	16	30	in	in	ADP
brainmatters-882	16	31	the	the	DET
brainmatters-882	16	32	progression	progression	NOUN
brainmatters-882	16	33	of	of	ADP
brainmatters-882	16	34	alzheimers	alzheimer	NOUN
brainmatters-882	16	35	.	.	PUNCT
brainmatters-882	17	1	once	once	SCONJ
brainmatters-882	17	2	neuronal	neuronal	ADJ
brainmatters-882	17	3	networks	network	NOUN
brainmatters-882	17	4	begin	begin	VERB
brainmatters-882	17	5	to	to	PART
brainmatters-882	17	6	disappear	disappear	VERB
brainmatters-882	17	7	,	,	PUNCT
brainmatters-882	17	8	the	the	DET
brainmatters-882	17	9	memory	memory	NOUN
brainmatters-882	17	10	of	of	ADP
brainmatters-882	17	11	the	the	DET
brainmatters-882	17	12	individual	individual	NOUN
brainmatters-882	17	13	,	,	PUNCT
brainmatters-882	17	14	with	with	ADP
brainmatters-882	17	15	parts	part	NOUN
brainmatters-882	17	16	of	of	ADP
brainmatters-882	17	17	the	the	DET
brainmatters-882	17	18	brain	brain	NOUN
brainmatters-882	17	19	such	such	ADJ
brainmatters-882	17	20	as	as	ADP
brainmatters-882	17	21	the	the	DET
brainmatters-882	17	22	hippocampus	hippocampus	NOUN
brainmatters-882	17	23	and	and	CCONJ
brainmatters-882	17	24	entorhinal	entorhinal	ADJ
brainmatters-882	17	25	cortex	cortex	NOUN
brainmatters-882	17	26	,	,	PUNCT
brainmatters-882	17	27	is	be	AUX
brainmatters-882	17	28	the	the	DET
brainmatters-882	17	29	first	first	ADJ
brainmatters-882	17	30	to	to	PART
brainmatters-882	17	31	be	be	AUX
brainmatters-882	17	32	affected	affect	VERB
brainmatters-882	17	33	.	.	PUNCT
brainmatters-882	18	1	as	as	SCONJ
brainmatters-882	18	2	the	the	DET
brainmatters-882	18	3	disease	disease	NOUN
brainmatters-882	18	4	spreads	spread	VERB
brainmatters-882	18	5	,	,	PUNCT
brainmatters-882	18	6	the	the	DET
brainmatters-882	18	7	cerebral	cerebral	ADJ
brainmatters-882	18	8	cortex	cortex	NOUN
brainmatters-882	18	9	of	of	ADP
brainmatters-882	18	10	the	the	DET
brainmatters-882	18	11	brain	brain	NOUN
brainmatters-882	18	12	is	be	AUX
brainmatters-882	18	13	next	next	ADJ
brainmatters-882	18	14	,	,	PUNCT
brainmatters-882	18	15	and	and	CCONJ
brainmatters-882	18	16	ultimately	ultimately	ADV
brainmatters-882	18	17	individuals	individual	NOUN
brainmatters-882	18	18	may	may	AUX
brainmatters-882	18	19	be	be	AUX
brainmatters-882	18	20	unable	unable	ADJ
brainmatters-882	18	21	to	to	PART
brainmatters-882	18	22	carry	carry	VERB
brainmatters-882	18	23	out	out	ADP
brainmatters-882	18	24	many	many	ADJ
brainmatters-882	18	25	basic	basic	ADJ
brainmatters-882	18	26	behaviors	behavior	NOUN
brainmatters-882	18	27	independently	independently	ADV
brainmatters-882	18	28	.	.	PUNCT
brainmatters-882	19	1	with	with	ADP
brainmatters-882	19	2	such	such	DET
brainmatters-882	19	3	an	an	DET
brainmatters-882	19	4	extreme	extreme	ADJ
brainmatters-882	19	5	increase	increase	NOUN
brainmatters-882	19	6	in	in	ADP
brainmatters-882	19	7	severity	severity	NOUN
brainmatters-882	19	8	,	,	PUNCT
brainmatters-882	19	9	researchers	researcher	NOUN
brainmatters-882	19	10	have	have	AUX
brainmatters-882	19	11	attempted	attempt	VERB
brainmatters-882	19	12	to	to	PART
brainmatters-882	19	13	devise	devise	VERB
brainmatters-882	19	14	methods	method	NOUN
brainmatters-882	19	15	that	that	PRON
brainmatters-882	19	16	will	will	AUX
brainmatters-882	19	17	be	be	AUX
brainmatters-882	19	18	able	able	ADJ
brainmatters-882	19	19	to	to	PART
brainmatters-882	19	20	treat	treat	VERB
brainmatters-882	19	21	alzheimers	alzheimer	NOUN
brainmatters-882	19	22	and	and	CCONJ
brainmatters-882	19	23	be	be	AUX
brainmatters-882	19	24	able	able	ADJ
brainmatters-882	19	25	to	to	PART
brainmatters-882	19	26	reduce	reduce	VERB
brainmatters-882	19	27	the	the	DET
brainmatters-882	19	28	symptoms	symptom	NOUN
brainmatters-882	19	29	gained	gain	VERB
brainmatters-882	19	30	as	as	ADP
brainmatters-882	19	31	a	a	DET
brainmatters-882	19	32	result	result	NOUN
brainmatters-882	19	33	of	of	ADP
brainmatters-882	19	34	it	it	PRON
brainmatters-882	19	35	.	.	PUNCT
brainmatters-882	20	1	while	while	SCONJ
brainmatters-882	20	2	originally	originally	ADV
brainmatters-882	20	3	researchers	researcher	NOUN
brainmatters-882	20	4	believed	believe	VERB
brainmatters-882	20	5	that	that	SCONJ
brainmatters-882	20	6	a	a	DET
brainmatters-882	20	7	type	type	NOUN
brainmatters-882	20	8	of	of	ADP
brainmatters-882	20	9	anti	anti	ADJ
brainmatters-882	20	10	-	-	ADJ
brainmatters-882	20	11	beta	beta	ADJ
brainmatters-882	20	12	amyloid	amyloid	NOUN
brainmatters-882	20	13	drug	drug	NOUN
brainmatters-882	20	14	would	would	AUX
brainmatters-882	20	15	be	be	AUX
brainmatters-882	20	16	a	a	DET
brainmatters-882	20	17	viable	viable	ADJ
brainmatters-882	20	18	solution	solution	NOUN
brainmatters-882	20	19	,	,	PUNCT
brainmatters-882	20	20	it	it	PRON
brainmatters-882	20	21	was	be	AUX
brainmatters-882	20	22	soon	soon	ADV
brainmatters-882	20	23	understood	understand	VERB
brainmatters-882	20	24	that	that	SCONJ
brainmatters-882	20	25	the	the	DET
brainmatters-882	20	26	state	state	NOUN
brainmatters-882	20	27	of	of	ADP
brainmatters-882	20	28	the	the	DET
brainmatters-882	20	29	disease	disease	NOUN
brainmatters-882	20	30	was	be	AUX
brainmatters-882	20	31	already	already	ADV
brainmatters-882	20	32	at	at	ADP
brainmatters-882	20	33	a	a	DET
brainmatters-882	20	34	level	level	NOUN
brainmatters-882	20	35	of	of	ADP
brainmatters-882	20	36	severity	severity	NOUN
brainmatters-882	20	37	where	where	SCONJ
brainmatters-882	20	38	simply	simply	ADV
brainmatters-882	20	39	treating	treat	VERB
brainmatters-882	20	40	it	it	PRON
brainmatters-882	20	41	by	by	ADP
brainmatters-882	20	42	affecting	affect	VERB
brainmatters-882	20	43	the	the	DET
brainmatters-882	20	44	amount	amount	NOUN
brainmatters-882	20	45	of	of	ADP
brainmatters-882	20	46	beta	beta	NOUN
brainmatters-882	20	47	-	-	PUNCT
brainmatters-882	20	48	amyloid	amyloid	NOUN
brainmatters-882	20	49	protein	protein	NOUN
brainmatters-882	20	50	in	in	ADP
brainmatters-882	20	51	the	the	DET
brainmatters-882	20	52	brain	brain	NOUN
brainmatters-882	20	53	would	would	AUX
brainmatters-882	20	54	not	not	PART
brainmatters-882	20	55	necessarily	necessarily	ADV
brainmatters-882	20	56	result	result	VERB
brainmatters-882	20	57	in	in	ADP
brainmatters-882	20	58	a	a	DET
brainmatters-882	20	59	major	major	ADJ
brainmatters-882	20	60	change	change	NOUN
brainmatters-882	20	61	of	of	ADP
brainmatters-882	20	62	quality	quality	NOUN
brainmatters-882	20	63	of	of	ADP
brainmatters-882	20	64	life	life	NOUN
brainmatters-882	20	65	nor	nor	CCONJ
brainmatters-882	20	66	health	health	NOUN
brainmatters-882	20	67	.	.	PUNCT
brainmatters-882	21	1	in	in	ADP
brainmatters-882	21	2	order	order	NOUN
brainmatters-882	21	3	to	to	PART
brainmatters-882	21	4	target	target	VERB
brainmatters-882	21	5	the	the	DET
brainmatters-882	21	6	protein	protein	NOUN
brainmatters-882	21	7	,	,	PUNCT
brainmatters-882	21	8	the	the	DET
brainmatters-882	21	9	protein	protein	NOUN
brainmatters-882	21	10	accumulation	accumulation	NOUN
brainmatters-882	21	11	is	be	AUX
brainmatters-882	21	12	removed	remove	VERB
brainmatters-882	21	13	as	as	ADV
brainmatters-882	21	14	efficiently	efficiently	ADV
brainmatters-882	21	15	and	and	CCONJ
brainmatters-882	21	16	quickly	quickly	ADV
brainmatters-882	21	17	as	as	ADP
brainmatters-882	21	18	possible	possible	ADJ
brainmatters-882	21	19	in	in	ADP
brainmatters-882	21	20	order	order	NOUN
brainmatters-882	21	21	to	to	PART
brainmatters-882	21	22	preserve	preserve	VERB
brainmatters-882	21	23	the	the	DET
brainmatters-882	21	24	remaining	remain	VERB
brainmatters-882	21	25	parts	part	NOUN
brainmatters-882	21	26	of	of	ADP
brainmatters-882	21	27	the	the	DET
brainmatters-882	21	28	brain	brain	NOUN
brainmatters-882	21	29	.	.	PUNCT
brainmatters-882	22	1	due	due	ADP
brainmatters-882	22	2	to	to	ADP
brainmatters-882	22	3	the	the	DET
brainmatters-882	22	4	precision	precision	NOUN
brainmatters-882	22	5	of	of	ADP
brainmatters-882	22	6	gene	gene	NOUN
brainmatters-882	22	7	editing	editing	NOUN
brainmatters-882	22	8	and	and	CCONJ
brainmatters-882	22	9	the	the	DET
brainmatters-882	22	10	nature	nature	NOUN
brainmatters-882	22	11	of	of	ADP
brainmatters-882	22	12	the	the	DET
brainmatters-882	22	13	disease	disease	NOUN
brainmatters-882	22	14	,	,	PUNCT
brainmatters-882	22	15	teams	team	NOUN
brainmatters-882	22	16	worldwide	worldwide	ADV
brainmatters-882	22	17	have	have	AUX
brainmatters-882	22	18	been	be	AUX
brainmatters-882	22	19	examining	examine	VERB
brainmatters-882	22	20	the	the	DET
brainmatters-882	22	21	potential	potential	NOUN
brainmatters-882	22	22	to	to	PART
brainmatters-882	22	23	treat	treat	VERB
brainmatters-882	22	24	alzheimers	alzheimer	NOUN
brainmatters-882	22	25	using	use	VERB
brainmatters-882	22	26	a	a	DET
brainmatters-882	22	27	variety	variety	NOUN
brainmatters-882	22	28	of	of	ADP
brainmatters-882	22	29	gene	gene	NOUN
brainmatters-882	22	30	editing	edit	VERB
brainmatters-882	22	31	techniques	technique	NOUN
brainmatters-882	22	32	.	.	PUNCT
brainmatters-882	23	1	a	a	DET
brainmatters-882	23	2	significant	significant	ADJ
brainmatters-882	23	3	positive	positive	ADJ
brainmatters-882	23	4	towards	towards	ADP
brainmatters-882	23	5	gene	gene	NOUN
brainmatters-882	23	6	editing	editing	NOUN
brainmatters-882	23	7	would	would	AUX
brainmatters-882	23	8	be	be	AUX
brainmatters-882	23	9	the	the	DET
brainmatters-882	23	10	failure	failure	NOUN
brainmatters-882	23	11	of	of	ADP
brainmatters-882	23	12	other	other	ADJ
brainmatters-882	23	13	treatments	treatment	NOUN
brainmatters-882	23	14	to	to	PART
brainmatters-882	23	15	surpass	surpass	VERB
brainmatters-882	23	16	the	the	DET
brainmatters-882	23	17	blood	blood	NOUN
brainmatters-882	23	18	-	-	PUNCT
brainmatters-882	23	19	brain	brain	NOUN
brainmatters-882	23	20	barrier	barrier	NOUN
brainmatters-882	23	21	;	;	PUNCT
brainmatters-882	23	22	however	however	ADV
brainmatters-882	23	23	,	,	PUNCT
brainmatters-882	23	24	gene	gene	NOUN
brainmatters-882	23	25	therapy	therapy	NOUN
brainmatters-882	23	26	has	have	VERB
brainmatters-882	23	27	the	the	DET
brainmatters-882	23	28	ability	ability	NOUN
brainmatters-882	23	29	to	to	PART
brainmatters-882	23	30	surpass	surpass	VERB
brainmatters-882	23	31	such	such	ADJ
brainmatters-882	23	32	obstructions	obstruction	NOUN
brainmatters-882	23	33	.	.	PUNCT
brainmatters-882	24	1	despite	despite	SCONJ
brainmatters-882	24	2	this	this	PRON
brainmatters-882	24	3	,	,	PUNCT
brainmatters-882	24	4	many	many	ADJ
brainmatters-882	24	5	experiments	experiment	NOUN
brainmatters-882	24	6	regarding	regard	VERB
brainmatters-882	24	7	gene	gene	NOUN
brainmatters-882	24	8	editing	editing	NOUN
brainmatters-882	24	9	have	have	AUX
brainmatters-882	24	10	not	not	PART
brainmatters-882	24	11	yet	yet	ADV
brainmatters-882	24	12	resulted	result	VERB
brainmatters-882	24	13	in	in	ADP
brainmatters-882	24	14	effects	effect	NOUN
brainmatters-882	24	15	that	that	PRON
brainmatters-882	24	16	would	would	AUX
brainmatters-882	24	17	be	be	AUX
brainmatters-882	24	18	considered	consider	VERB
brainmatters-882	24	19	noteworthy	noteworthy	ADJ
brainmatters-882	24	20	to	to	ADP
brainmatters-882	24	21	the	the	DET
brainmatters-882	24	22	point	point	NOUN
brainmatters-882	24	23	of	of	ADP
brainmatters-882	24	24	a	a	DET
brainmatters-882	24	25	fixed	fix	VERB
brainmatters-882	24	26	treatment	treatment	NOUN
brainmatters-882	24	27	.	.	PUNCT
brainmatters-882	25	1	researchers	researcher	NOUN
brainmatters-882	25	2	wish	wish	VERB
brainmatters-882	25	3	to	to	PART
brainmatters-882	25	4	continue	continue	VERB
brainmatters-882	25	5	experimentation	experimentation	NOUN
brainmatters-882	25	6	by	by	ADP
brainmatters-882	25	7	altering	alter	VERB
brainmatters-882	25	8	the	the	DET
brainmatters-882	25	9	type	type	NOUN
brainmatters-882	25	10	of	of	ADP
brainmatters-882	25	11	viral	viral	ADJ
brainmatters-882	25	12	vector	vector	NOUN
brainmatters-882	25	13	,	,	PUNCT
brainmatters-882	25	14	target	target	NOUN
brainmatters-882	25	15	for	for	ADP
brainmatters-882	25	16	the	the	DET
brainmatters-882	25	17	therapeutic	therapeutic	ADJ
brainmatters-882	25	18	gene	gene	NOUN
brainmatters-882	25	19	,	,	PUNCT
brainmatters-882	25	20	and	and	CCONJ
brainmatters-882	25	21	the	the	DET
brainmatters-882	25	22	route	route	NOUN
brainmatters-882	25	23	through	through	ADP
brainmatters-882	25	24	which	which	PRON
brainmatters-882	25	25	the	the	DET
brainmatters-882	25	26	vector	vector	NOUN
brainmatters-882	25	27	should	should	AUX
brainmatters-882	25	28	take	take	VERB
brainmatters-882	25	29	.	.	PUNCT
brainmatters-882	26	1	viral	viral	ADJ
brainmatters-882	26	2	vectors	vector	NOUN
brainmatters-882	26	3	are	be	AUX
brainmatters-882	26	4	considered	consider	VERB
brainmatters-882	26	5	one	one	NUM
brainmatters-882	26	6	of	of	ADP
brainmatters-882	26	7	the	the	DET
brainmatters-882	26	8	most	most	ADV
brainmatters-882	26	9	effective	effective	ADJ
brainmatters-882	26	10	ways	way	NOUN
brainmatters-882	26	11	for	for	ADP
brainmatters-882	26	12	gene	gene	NOUN
brainmatters-882	26	13	delivery	delivery	NOUN
brainmatters-882	26	14	to	to	ADP
brainmatters-882	26	15	any	any	DET
brainmatters-882	26	16	target	target	NOUN
brainmatters-882	26	17	cells	cell	NOUN
brainmatters-882	26	18	.	.	PUNCT
brainmatters-882	27	1	when	when	SCONJ
brainmatters-882	27	2	done	do	VERB
brainmatters-882	27	3	ex	ex	NOUN
brainmatters-882	27	4	-	-	NOUN
brainmatters-882	27	5	vivo	vivo	ADJ
brainmatters-882	27	6	,	,	PUNCT
brainmatters-882	27	7	the	the	DET
brainmatters-882	27	8	target	target	NOUN
brainmatters-882	27	9	cells	cell	NOUN
brainmatters-882	27	10	are	be	AUX
brainmatters-882	27	11	drawn	draw	VERB
brainmatters-882	27	12	out	out	ADP
brainmatters-882	27	13	from	from	ADP
brainmatters-882	27	14	the	the	DET
brainmatters-882	27	15	organism	organism	NOUN
brainmatters-882	27	16	’s	’s	PART
brainmatters-882	27	17	body	body	NOUN
brainmatters-882	27	18	,	,	PUNCT
brainmatters-882	27	19	then	then	ADV
brainmatters-882	27	20	introduced	introduce	VERB
brainmatters-882	27	21	to	to	ADP
brainmatters-882	27	22	the	the	DET
brainmatters-882	27	23	therapeutic	therapeutic	ADJ
brainmatters-882	27	24	gene	gene	NOUN
brainmatters-882	27	25	,	,	PUNCT
brainmatters-882	27	26	and	and	CCONJ
brainmatters-882	27	27	planted	plant	VERB
brainmatters-882	27	28	back	back	ADV
brainmatters-882	27	29	into	into	ADP
brainmatters-882	27	30	the	the	DET
brainmatters-882	27	31	organism	organism	NOUN
brainmatters-882	27	32	;	;	PUNCT
brainmatters-882	27	33	in	in	ADP
brainmatters-882	27	34	-	-	PUNCT
brainmatters-882	27	35	vivo	vivo	NOUN
brainmatters-882	27	36	requires	require	VERB
brainmatters-882	27	37	the	the	DET
brainmatters-882	27	38	process	process	NOUN
brainmatters-882	27	39	to	to	PART
brainmatters-882	27	40	be	be	AUX
brainmatters-882	27	41	done	do	VERB
brainmatters-882	27	42	within	within	ADP
brainmatters-882	27	43	the	the	DET
brainmatters-882	27	44	organism	organism	NOUN
brainmatters-882	27	45	itself	itself	PRON
brainmatters-882	27	46	.	.	PUNCT
brainmatters-882	28	1	this	this	PRON
brainmatters-882	28	2	can	can	AUX
brainmatters-882	28	3	result	result	VERB
brainmatters-882	28	4	in	in	ADP
brainmatters-882	28	5	either	either	CCONJ
brainmatters-882	28	6	gene	gene	NOUN
brainmatters-882	28	7	silencing	silence	VERB
brainmatters-882	28	8	or	or	CCONJ
brainmatters-882	28	9	overexpression	overexpression	NOUN
brainmatters-882	28	10	,	,	PUNCT
brainmatters-882	28	11	all	all	PRON
brainmatters-882	28	12	of	of	ADP
brainmatters-882	28	13	which	which	PRON
brainmatters-882	28	14	is	be	AUX
brainmatters-882	28	15	dependent	dependent	ADJ
brainmatters-882	28	16	on	on	ADP
brainmatters-882	28	17	the	the	DET
brainmatters-882	28	18	target	target	NOUN
brainmatters-882	28	19	cell	cell	NOUN
brainmatters-882	28	20	itself	itself	PRON
brainmatters-882	28	21	.	.	PUNCT
brainmatters-882	29	1	considering	consider	VERB
brainmatters-882	29	2	the	the	DET
brainmatters-882	29	3	wide	wide	ADJ
brainmatters-882	29	4	range	range	NOUN
brainmatters-882	29	5	in	in	ADP
brainmatters-882	29	6	virus	virus	NOUN
brainmatters-882	29	7	shapes	shape	NOUN
brainmatters-882	29	8	and	and	CCONJ
brainmatters-882	29	9	structures	structure	NOUN
brainmatters-882	29	10	,	,	PUNCT
brainmatters-882	29	11	many	many	ADJ
brainmatters-882	29	12	types	type	NOUN
brainmatters-882	29	13	of	of	ADP
brainmatters-882	29	14	viral	viral	ADJ
brainmatters-882	29	15	vectors	vector	NOUN
brainmatters-882	29	16	are	be	AUX
brainmatters-882	29	17	utilized	utilize	VERB
brainmatters-882	29	18	in	in	ADP
brainmatters-882	29	19	order	order	NOUN
brainmatters-882	29	20	to	to	PART
brainmatters-882	29	21	attain	attain	VERB
brainmatters-882	29	22	precision	precision	NOUN
brainmatters-882	29	23	and	and	CCONJ
brainmatters-882	29	24	efficacy	efficacy	NOUN
brainmatters-882	29	25	.	.	PUNCT
brainmatters-882	30	1	in	in	ADP
brainmatters-882	30	2	treatments	treatment	NOUN
brainmatters-882	30	3	for	for	ADP
brainmatters-882	30	4	alzheimers	alzheimer	NOUN
brainmatters-882	30	5	,	,	PUNCT
brainmatters-882	30	6	researchers	researcher	NOUN
brainmatters-882	30	7	have	have	AUX
brainmatters-882	30	8	traditionally	traditionally	ADV
brainmatters-882	30	9	experimented	experiment	VERB
brainmatters-882	30	10	with	with	ADP
brainmatters-882	30	11	adeno	adeno	NOUN
brainmatters-882	30	12	-	-	PUNCT
brainmatters-882	30	13	associated	associate	VERB
brainmatters-882	30	14	virus	virus	NOUN
brainmatters-882	30	15	(	(	PUNCT
brainmatters-882	30	16	aav	aav	NOUN
brainmatters-882	30	17	)	)	PUNCT
brainmatters-882	30	18	vectors	vector	NOUN
brainmatters-882	30	19	,	,	PUNCT
brainmatters-882	30	20	due	due	ADP
brainmatters-882	30	21	to	to	ADP
brainmatters-882	30	22	their	their	PRON
brainmatters-882	30	23	non	non	ADJ
brainmatters-882	30	24	-	-	ADJ
brainmatters-882	30	25	toxic	toxic	ADJ
brainmatters-882	30	26	and	and	CCONJ
brainmatters-882	30	27	non	non	ADJ
brainmatters-882	30	28	-	-	ADJ
brainmatters-882	30	29	pathogenic	pathogenic	ADJ
brainmatters-882	30	30	nature	nature	NOUN
brainmatters-882	30	31	.	.	PUNCT
brainmatters-882	31	1	taking	take	VERB
brainmatters-882	31	2	into	into	ADP
brainmatters-882	31	3	account	account	NOUN
brainmatters-882	31	4	the	the	DET
brainmatters-882	31	5	possibility	possibility	NOUN
brainmatters-882	31	6	of	of	ADP
brainmatters-882	31	7	mutagenesis	mutagenesis	NOUN
brainmatters-882	31	8	in	in	ADP
brainmatters-882	31	9	the	the	DET
brainmatters-882	31	10	body	body	NOUN
brainmatters-882	31	11	,	,	PUNCT
brainmatters-882	31	12	it	it	PRON
brainmatters-882	31	13	is	be	AUX
brainmatters-882	31	14	essential	essential	ADJ
brainmatters-882	31	15	that	that	SCONJ
brainmatters-882	31	16	the	the	DET
brainmatters-882	31	17	viral	viral	ADJ
brainmatters-882	31	18	vector	vector	NOUN
brainmatters-882	31	19	must	must	AUX
brainmatters-882	31	20	possess	possess	VERB
brainmatters-882	31	21	these	these	DET
brainmatters-882	31	22	two	two	NUM
brainmatters-882	31	23	qualities	quality	NOUN
brainmatters-882	31	24	.	.	PUNCT
brainmatters-882	32	1	researchers	researcher	NOUN
brainmatters-882	32	2	identified	identify	VERB
brainmatters-882	32	3	around	around	ADP
brainmatters-882	32	4	100	100	NUM
brainmatters-882	32	5	av	av	PROPN
brainmatters-882	32	6	variants	variant	NOUN
brainmatters-882	32	7	with	with	ADP
brainmatters-882	32	8	a	a	DET
brainmatters-882	32	9	range	range	NOUN
brainmatters-882	32	10	of	of	ADP
brainmatters-882	32	11	13	13	NUM
brainmatters-882	32	12	serotypes	serotype	NOUN
brainmatters-882	32	13	;	;	PUNCT
brainmatters-882	32	14	although	although	SCONJ
brainmatters-882	32	15	multiple	multiple	ADJ
brainmatters-882	32	16	have	have	AUX
brainmatters-882	32	17	been	be	AUX
brainmatters-882	32	18	deemed	deem	VERB
brainmatters-882	32	19	adequate	adequate	ADJ
brainmatters-882	32	20	for	for	ADP
brainmatters-882	32	21	experimentation	experimentation	NOUN
brainmatters-882	32	22	,	,	PUNCT
brainmatters-882	32	23	aav2	aav2	PROPN
brainmatters-882	32	24	is	be	AUX
brainmatters-882	32	25	used	use	VERB
brainmatters-882	32	26	most	most	ADV
brainmatters-882	32	27	frequently	frequently	ADV
brainmatters-882	32	28	due	due	ADP
brainmatters-882	32	29	to	to	ADP
brainmatters-882	32	30	its	its	PRON
brainmatters-882	32	31	high	high	ADJ
brainmatters-882	32	32	level	level	NOUN
brainmatters-882	32	33	of	of	ADP
brainmatters-882	32	34	safety	safety	NOUN
brainmatters-882	32	35	and	and	CCONJ
brainmatters-882	32	36	sustained	sustained	ADJ
brainmatters-882	32	37	expression	expression	NOUN
brainmatters-882	32	38	of	of	ADP
brainmatters-882	32	39	the	the	DET
brainmatters-882	32	40	therapeutic	therapeutic	ADJ
brainmatters-882	32	41	gene	gene	NOUN
brainmatters-882	32	42	within	within	ADP
brainmatters-882	32	43	the	the	DET
brainmatters-882	32	44	neuron	neuron	NOUN
brainmatters-882	32	45	.	.	PUNCT
brainmatters-882	33	1	along	along	ADP
brainmatters-882	33	2	with	with	ADP
brainmatters-882	33	3	the	the	DET
brainmatters-882	33	4	identified	identify	VERB
brainmatters-882	33	5	aavs	aavs	NOUN
brainmatters-882	33	6	,	,	PUNCT
brainmatters-882	33	7	a	a	DET
brainmatters-882	33	8	genetically	genetically	ADV
brainmatters-882	33	9	engineered	engineer	VERB
brainmatters-882	33	10	aav	aav	NOUN
brainmatters-882	33	11	capsid	capsid	NOUN
brainmatters-882	33	12	(	(	PUNCT
brainmatters-882	33	13	aav	aav	NOUN
brainmatters-882	33	14	-	-	PUNCT
brainmatters-882	33	15	php.b	php.b	PROPN
brainmatters-882	33	16	)	)	PUNCT
brainmatters-882	33	17	has	have	AUX
brainmatters-882	33	18	been	be	AUX
brainmatters-882	33	19	utilized	utilize	VERB
brainmatters-882	33	20	in	in	ADP
brainmatters-882	33	21	studies	study	NOUN
brainmatters-882	33	22	and	and	CCONJ
brainmatters-882	33	23	expresses	express	VERB
brainmatters-882	33	24	the	the	DET
brainmatters-882	33	25	ability	ability	NOUN
brainmatters-882	33	26	to	to	PART
brainmatters-882	33	27	deliver	deliver	VERB
brainmatters-882	33	28	a	a	DET
brainmatters-882	33	29	greater	great	ADJ
brainmatters-882	33	30	capacity	capacity	NOUN
brainmatters-882	33	31	of	of	ADP
brainmatters-882	33	32	aav	aav	NOUN
brainmatters-882	33	33	12brain	12brain	NUM
brainmatters-882	33	34	matters	matter	NOUN
brainmatters-882	33	35	volume	volume	NOUN
brainmatters-882	33	36	vi	vi	NOUN
brainmatters-882	33	37	highly	highly	ADV
brainmatters-882	33	38	precise	precise	ADJ
brainmatters-882	33	39	,	,	PUNCT
brainmatters-882	33	40	gene	gene	NOUN
brainmatters-882	33	41	-	-	PUNCT
brainmatters-882	33	42	editing	edit	VERB
brainmatters-882	33	43	techniques	technique	NOUN
brainmatters-882	33	44	and	and	CCONJ
brainmatters-882	33	45	therapies	therapy	NOUN
brainmatters-882	33	46	have	have	AUX
brainmatters-882	33	47	improved	improve	VERB
brainmatters-882	33	48	greatly	greatly	ADV
brainmatters-882	33	49	as	as	ADP
brainmatters-882	33	50	a	a	DET
brainmatters-882	33	51	result	result	NOUN
brainmatters-882	33	52	of	of	ADP
brainmatters-882	33	53	this	this	DET
brainmatters-882	33	54	technology	technology	NOUN
brainmatters-882	33	55	.	.	PUNCT
brainmatters-882	34	1	comprised	comprise	VERB
brainmatters-882	34	2	of	of	ADP
brainmatters-882	34	3	a	a	DET
brainmatters-882	34	4	singular	singular	ADJ
brainmatters-882	34	5	enzyme	enzyme	NOUN
brainmatters-882	34	6	(	(	PUNCT
brainmatters-882	34	7	cas9	cas9	PROPN
brainmatters-882	34	8	)	)	PUNCT
brainmatters-882	34	9	and	and	CCONJ
brainmatters-882	34	10	a	a	DET
brainmatters-882	34	11	single	single	ADJ
brainmatters-882	34	12	guide	guide	NOUN
brainmatters-882	34	13	rna	rna	PROPN
brainmatters-882	34	14	(	(	PUNCT
brainmatters-882	34	15	sgrna	sgrna	PROPN
brainmatters-882	34	16	)	)	PUNCT
brainmatters-882	34	17	,	,	PUNCT
brainmatters-882	34	18	the	the	DET
brainmatters-882	34	19	target	target	NOUN
brainmatters-882	34	20	dna	dna	NOUN
brainmatters-882	34	21	sequence	sequence	NOUN
brainmatters-882	34	22	is	be	AUX
brainmatters-882	34	23	registered	register	VERB
brainmatters-882	34	24	and	and	CCONJ
brainmatters-882	34	25	recognized	recognize	VERB
brainmatters-882	34	26	by	by	ADP
brainmatters-882	34	27	the	the	DET
brainmatters-882	34	28	sgrna	sgrna	NOUN
brainmatters-882	34	29	,	,	PUNCT
brainmatters-882	34	30	and	and	CCONJ
brainmatters-882	34	31	cleaved	cleave	VERB
brainmatters-882	34	32	by	by	ADP
brainmatters-882	34	33	the	the	DET
brainmatters-882	34	34	cas9	cas9	NOUN
brainmatters-882	34	35	endonuclease	endonuclease	NOUN
brainmatters-882	34	36	,	,	PUNCT
brainmatters-882	34	37	resulting	result	VERB
brainmatters-882	34	38	in	in	ADP
brainmatters-882	34	39	either	either	CCONJ
brainmatters-882	34	40	a	a	DET
brainmatters-882	34	41	replacing	replacing	NOUN
brainmatters-882	34	42	of	of	ADP
brainmatters-882	34	43	the	the	DET
brainmatters-882	34	44	mutated	mutate	VERB
brainmatters-882	34	45	sequence	sequence	NOUN
brainmatters-882	34	46	or	or	CCONJ
brainmatters-882	34	47	the	the	DET
brainmatters-882	34	48	insertion	insertion	NOUN
brainmatters-882	34	49	and	and	CCONJ
brainmatters-882	34	50	deletion	deletion	NOUN
brainmatters-882	34	51	of	of	ADP
brainmatters-882	34	52	sequences	sequence	NOUN
brainmatters-882	34	53	for	for	ADP
brainmatters-882	34	54	inactivation	inactivation	NOUN
brainmatters-882	34	55	.	.	PUNCT
brainmatters-882	35	1	considering	consider	VERB
brainmatters-882	35	2	that	that	SCONJ
brainmatters-882	35	3	genetic	genetic	ADJ
brainmatters-882	35	4	mutations	mutation	NOUN
brainmatters-882	35	5	only	only	ADV
brainmatters-882	35	6	comprise	comprise	VERB
brainmatters-882	35	7	around	around	ADV
brainmatters-882	35	8	1	1	NUM
brainmatters-882	35	9	%	%	NOUN
brainmatters-882	35	10	of	of	ADP
brainmatters-882	35	11	familial	familial	ADJ
brainmatters-882	35	12	alzheimer	alzheimer	NOUN
brainmatters-882	35	13	's	's	PART
brainmatters-882	35	14	cases	case	NOUN
brainmatters-882	35	15	,	,	PUNCT
brainmatters-882	35	16	crispr	crispr	NOUN
brainmatters-882	35	17	’s	’s	PART
brainmatters-882	35	18	role	role	NOUN
brainmatters-882	35	19	in	in	ADP
brainmatters-882	35	20	helping	help	VERB
brainmatters-882	35	21	patients	patient	NOUN
brainmatters-882	35	22	with	with	ADP
brainmatters-882	35	23	ad	ad	NOUN
brainmatters-882	35	24	may	may	AUX
brainmatters-882	35	25	be	be	AUX
brainmatters-882	35	26	limited	limit	VERB
brainmatters-882	35	27	to	to	ADP
brainmatters-882	35	28	changing	change	VERB
brainmatters-882	35	29	symptom	symptom	NOUN
brainmatters-882	35	30	expression	expression	NOUN
brainmatters-882	35	31	by	by	ADP
brainmatters-882	35	32	manipulating	manipulate	VERB
brainmatters-882	35	33	b	b	NUM
brainmatters-882	35	34	-	-	PUNCT
brainmatters-882	35	35	amyloid	amyloid	NOUN
brainmatters-882	35	36	metabolism	metabolism	NOUN
brainmatters-882	35	37	(	(	PUNCT
brainmatters-882	35	38	bhardwaj	bhardwaj	PROPN
brainmatters-882	35	39	,	,	PUNCT
brainmatters-882	35	40	s.	s.	PROPN
brainmatters-882	35	41	,	,	PUNCT
brainmatters-882	35	42	kesari	kesari	PROPN
brainmatters-882	35	43	,	,	PUNCT
brainmatters-882	35	44	k.	k.	PROPN
brainmatters-882	35	45	k.	k.	PROPN
brainmatters-882	35	46	,	,	PUNCT
brainmatters-882	35	47	rachamalla	rachamalla	NOUN
brainmatters-882	35	48	,	,	PUNCT
brainmatters-882	35	49	m.	m.	NOUN
brainmatters-882	35	50	,	,	PUNCT
brainmatters-882	35	51	mani	mani	PROPN
brainmatters-882	35	52	,	,	PUNCT
brainmatters-882	35	53	s	s	PROPN
brainmatters-882	35	54	,	,	PUNCT
brainmatters-882	35	55	et	et	NOUN
brainmatters-882	35	56	.	.	PUNCT
brainmatters-882	36	1	al	al	PROPN
brainmatters-882	36	2	,	,	PUNCT
brainmatters-882	36	3	2021	2021	NUM
brainmatters-882	36	4	)	)	PUNCT
brainmatters-882	36	5	.	.	PUNCT
brainmatters-882	37	1	while	while	SCONJ
brainmatters-882	37	2	the	the	DET
brainmatters-882	37	3	variety	variety	NOUN
brainmatters-882	37	4	of	of	ADP
brainmatters-882	37	5	findings	finding	NOUN
brainmatters-882	37	6	in	in	ADP
brainmatters-882	37	7	regards	regard	NOUN
brainmatters-882	37	8	to	to	ADP
brainmatters-882	37	9	gene	gene	NOUN
brainmatters-882	37	10	editing	editing	NOUN
brainmatters-882	37	11	and	and	CCONJ
brainmatters-882	37	12	the	the	DET
brainmatters-882	37	13	treatment	treatment	NOUN
brainmatters-882	37	14	of	of	ADP
brainmatters-882	37	15	alzheimer	alzheimer	PROPN
brainmatters-882	37	16	’s	’s	PART
brainmatters-882	37	17	disease	disease	NOUN
brainmatters-882	37	18	are	be	AUX
brainmatters-882	37	19	promising	promise	VERB
brainmatters-882	37	20	,	,	PUNCT
brainmatters-882	37	21	much	much	ADJ
brainmatters-882	37	22	work	work	NOUN
brainmatters-882	37	23	is	be	AUX
brainmatters-882	37	24	needed	need	VERB
brainmatters-882	37	25	to	to	PART
brainmatters-882	37	26	ensure	ensure	VERB
brainmatters-882	37	27	the	the	DET
brainmatters-882	37	28	safety	safety	NOUN
brainmatters-882	37	29	of	of	ADP
brainmatters-882	37	30	procedures	procedure	NOUN
brainmatters-882	37	31	on	on	ADP
brainmatters-882	37	32	the	the	DET
brainmatters-882	37	33	human	human	ADJ
brainmatters-882	37	34	brain	brain	NOUN
brainmatters-882	37	35	and	and	CCONJ
brainmatters-882	37	36	their	their	PRON
brainmatters-882	37	37	efficacy	efficacy	NOUN
brainmatters-882	37	38	.	.	PUNCT
brainmatters-882	38	1	host	host	NOUN
brainmatters-882	38	2	responses	response	NOUN
brainmatters-882	38	3	to	to	ADP
brainmatters-882	38	4	viral	viral	ADJ
brainmatters-882	38	5	vectors	vector	NOUN
brainmatters-882	38	6	may	may	AUX
brainmatters-882	38	7	prove	prove	VERB
brainmatters-882	38	8	to	to	PART
brainmatters-882	38	9	be	be	AUX
brainmatters-882	38	10	dangerous	dangerous	ADJ
brainmatters-882	38	11	,	,	PUNCT
brainmatters-882	38	12	as	as	SCONJ
brainmatters-882	38	13	is	be	AUX
brainmatters-882	38	14	the	the	DET
brainmatters-882	38	15	concern	concern	NOUN
brainmatters-882	38	16	of	of	ADP
brainmatters-882	38	17	patients	patient	NOUN
brainmatters-882	38	18	with	with	ADP
brainmatters-882	38	19	high	high	ADJ
brainmatters-882	38	20	-	-	PUNCT
brainmatters-882	38	21	functioning	function	VERB
brainmatters-882	38	22	immune	immune	ADJ
brainmatters-882	38	23	systems	system	NOUN
brainmatters-882	38	24	creating	create	VERB
brainmatters-882	38	25	antibodies	antibody	NOUN
brainmatters-882	38	26	with	with	ADP
brainmatters-882	38	27	the	the	DET
brainmatters-882	38	28	purpose	purpose	NOUN
brainmatters-882	38	29	of	of	ADP
brainmatters-882	38	30	neutralizing	neutralize	VERB
brainmatters-882	38	31	the	the	DET
brainmatters-882	38	32	inserted	insert	VERB
brainmatters-882	38	33	vectors	vector	NOUN
brainmatters-882	38	34	.	.	PUNCT
brainmatters-882	39	1	additionally	additionally	ADV
brainmatters-882	39	2	,	,	PUNCT
brainmatters-882	39	3	the	the	DET
brainmatters-882	39	4	ethics	ethic	NOUN
brainmatters-882	39	5	and	and	CCONJ
brainmatters-882	39	6	viability	viability	NOUN
brainmatters-882	39	7	of	of	ADP
brainmatters-882	39	8	a	a	DET
brainmatters-882	39	9	supposed	suppose	VERB
brainmatters-882	39	10	treatment	treatment	NOUN
brainmatters-882	39	11	must	must	AUX
brainmatters-882	39	12	be	be	AUX
brainmatters-882	39	13	taken	take	VERB
brainmatters-882	39	14	into	into	ADP
brainmatters-882	39	15	consideration	consideration	NOUN
brainmatters-882	39	16	;	;	PUNCT
brainmatters-882	39	17	factors	factor	NOUN
brainmatters-882	39	18	such	such	ADJ
brainmatters-882	39	19	as	as	ADP
brainmatters-882	39	20	cost	cost	NOUN
brainmatters-882	39	21	,	,	PUNCT
brainmatters-882	39	22	effectiveness	effectiveness	NOUN
brainmatters-882	39	23	,	,	PUNCT
brainmatters-882	39	24	and	and	CCONJ
brainmatters-882	39	25	availability	availability	NOUN
brainmatters-882	39	26	all	all	PRON
brainmatters-882	39	27	must	must	AUX
brainmatters-882	39	28	be	be	AUX
brainmatters-882	39	29	regarded	regard	VERB
brainmatters-882	39	30	.	.	PUNCT
brainmatters-882	40	1	improved	improve	VERB
brainmatters-882	40	2	knowledge	knowledge	NOUN
brainmatters-882	40	3	of	of	ADP
brainmatters-882	40	4	the	the	DET
brainmatters-882	40	5	mechanisms	mechanism	NOUN
brainmatters-882	40	6	behind	behind	ADP
brainmatters-882	40	7	alzheimer	alzheimer	PROPN
brainmatters-882	40	8	’s	’s	PART
brainmatters-882	40	9	and	and	CCONJ
brainmatters-882	40	10	their	their	PRON
brainmatters-882	40	11	connection	connection	NOUN
brainmatters-882	40	12	to	to	ADP
brainmatters-882	40	13	various	various	ADJ
brainmatters-882	40	14	parts	part	NOUN
brainmatters-882	40	15	of	of	ADP
brainmatters-882	40	16	the	the	DET
brainmatters-882	40	17	human	human	ADJ
brainmatters-882	40	18	body	body	NOUN
brainmatters-882	40	19	will	will	AUX
brainmatters-882	40	20	undoubtedly	undoubtedly	ADV
brainmatters-882	40	21	improve	improve	VERB
brainmatters-882	40	22	the	the	DET
brainmatters-882	40	23	potential	potential	ADJ
brainmatters-882	40	24	prospects	prospect	NOUN
brainmatters-882	40	25	for	for	ADP
brainmatters-882	40	26	treatment	treatment	NOUN
brainmatters-882	40	27	.	.	PUNCT
brainmatters-882	41	1	in	in	ADP
brainmatters-882	41	2	combination	combination	NOUN
brainmatters-882	41	3	with	with	ADP
brainmatters-882	41	4	the	the	DET
brainmatters-882	41	5	continued	continue	VERB
brainmatters-882	41	6	efforts	effort	NOUN
brainmatters-882	41	7	to	to	PART
brainmatters-882	41	8	find	find	VERB
brainmatters-882	41	9	suitable	suitable	ADJ
brainmatters-882	41	10	vectors	vector	NOUN
brainmatters-882	41	11	and	and	CCONJ
brainmatters-882	41	12	outline	outline	NOUN
brainmatters-882	41	13	target	target	NOUN
brainmatters-882	41	14	genes	gene	NOUN
brainmatters-882	41	15	,	,	PUNCT
brainmatters-882	41	16	many	many	ADJ
brainmatters-882	41	17	scientists	scientist	NOUN
brainmatters-882	41	18	and	and	CCONJ
brainmatters-882	41	19	doctors	doctor	NOUN
brainmatters-882	41	20	are	be	AUX
brainmatters-882	41	21	hopeful	hopeful	ADJ
brainmatters-882	41	22	that	that	SCONJ
brainmatters-882	41	23	gene	gene	NOUN
brainmatters-882	41	24	-	-	PUNCT
brainmatters-882	41	25	editing	edit	VERB
brainmatters-882	41	26	techniques	technique	NOUN
brainmatters-882	41	27	may	may	AUX
brainmatters-882	41	28	be	be	AUX
brainmatters-882	41	29	a	a	DET
brainmatters-882	41	30	potential	potential	ADJ
brainmatters-882	41	31	means	mean	NOUN
brainmatters-882	41	32	to	to	PART
brainmatters-882	41	33	find	find	VERB
brainmatters-882	41	34	a	a	DET
brainmatters-882	41	35	conclusive	conclusive	ADJ
brainmatters-882	41	36	treatment	treatment	NOUN
brainmatters-882	41	37	to	to	ADP
brainmatters-882	41	38	a	a	DET
brainmatters-882	41	39	disease	disease	NOUN
brainmatters-882	41	40	that	that	PRON
brainmatters-882	41	41	has	have	AUX
brainmatters-882	41	42	affected	affect	VERB
brainmatters-882	41	43	millions	million	NOUN
brainmatters-882	41	44	of	of	ADP
brainmatters-882	41	45	people	people	NOUN
brainmatters-882	41	46	worldwide	worldwide	ADV
brainmatters-882	41	47	.	.	PUNCT
brainmatters-882	42	1	brain	brain	NOUN
brainmatters-882	42	2	matters	matter	NOUN
brainmatters-882	42	3	volume	volume	NOUN
brainmatters-882	42	4	vi	vi	PROPN
brainmatters-882	42	5	genomes	genome	NOUN
brainmatters-882	42	6	to	to	ADP
brainmatters-882	42	7	the	the	DET
brainmatters-882	42	8	central	central	ADJ
brainmatters-882	42	9	nervous	nervous	ADJ
brainmatters-882	42	10	system	system	NOUN
brainmatters-882	42	11	(	(	PUNCT
brainmatters-882	42	12	cns	cns	NOUN
brainmatters-882	42	13	)	)	PUNCT
brainmatters-882	42	14	and	and	CCONJ
brainmatters-882	42	15	convert	convert	VERB
brainmatters-882	42	16	more	more	ADJ
brainmatters-882	42	17	than	than	ADP
brainmatters-882	42	18	50	50	NUM
brainmatters-882	42	19	%	%	NOUN
brainmatters-882	42	20	of	of	ADP
brainmatters-882	42	21	astrocytes	astrocyte	NOUN
brainmatters-882	42	22	and	and	CCONJ
brainmatters-882	42	23	neurons	neuron	NOUN
brainmatters-882	42	24	(	(	PUNCT
brainmatters-882	42	25	chen	chen	PROPN
brainmatters-882	42	26	,	,	PUNCT
brainmatters-882	42	27	w.	w.	PROPN
brainmatters-882	42	28	,	,	PUNCT
brainmatters-882	42	29	hu	hu	PROPN
brainmatters-882	42	30	,	,	PUNCT
brainmatters-882	42	31	y.	y.	PROPN
brainmatters-882	42	32	,	,	PUNCT
brainmatters-882	42	33	&	&	CCONJ
brainmatters-882	42	34	ju	ju	PROPN
brainmatters-882	42	35	,	,	PUNCT
brainmatters-882	42	36	d	d	NOUN
brainmatters-882	42	37	,	,	PUNCT
brainmatters-882	42	38	2020	2020	NUM
brainmatters-882	42	39	)	)	PUNCT
brainmatters-882	42	40	.	.	PUNCT
brainmatters-882	43	1	while	while	SCONJ
brainmatters-882	43	2	the	the	DET
brainmatters-882	43	3	selection	selection	NOUN
brainmatters-882	43	4	of	of	ADP
brainmatters-882	43	5	a	a	DET
brainmatters-882	43	6	vector	vector	NOUN
brainmatters-882	43	7	is	be	AUX
brainmatters-882	43	8	critical	critical	ADJ
brainmatters-882	43	9	,	,	PUNCT
brainmatters-882	43	10	researchers	researcher	NOUN
brainmatters-882	43	11	globally	globally	ADV
brainmatters-882	43	12	have	have	AUX
brainmatters-882	43	13	experimented	experiment	VERB
brainmatters-882	43	14	with	with	ADP
brainmatters-882	43	15	aav	aav	NOUN
brainmatters-882	43	16	vectors	vector	NOUN
brainmatters-882	43	17	and	and	CCONJ
brainmatters-882	43	18	various	various	ADJ
brainmatters-882	43	19	targets	target	NOUN
brainmatters-882	43	20	in	in	ADP
brainmatters-882	43	21	the	the	DET
brainmatters-882	43	22	body	body	NOUN
brainmatters-882	43	23	to	to	PART
brainmatters-882	43	24	treat	treat	VERB
brainmatters-882	43	25	alzheimers	alzheimer	NOUN
brainmatters-882	43	26	;	;	PUNCT
brainmatters-882	43	27	without	without	ADP
brainmatters-882	43	28	choosing	choose	VERB
brainmatters-882	43	29	the	the	DET
brainmatters-882	43	30	proper	proper	ADJ
brainmatters-882	43	31	target	target	NOUN
brainmatters-882	43	32	,	,	PUNCT
brainmatters-882	43	33	the	the	DET
brainmatters-882	43	34	therapeutic	therapeutic	ADJ
brainmatters-882	43	35	gene	gene	NOUN
brainmatters-882	43	36	may	may	AUX
brainmatters-882	43	37	simply	simply	ADV
brainmatters-882	43	38	diminish	diminish	VERB
brainmatters-882	43	39	symptoms	symptom	NOUN
brainmatters-882	43	40	slightly	slightly	ADV
brainmatters-882	43	41	while	while	SCONJ
brainmatters-882	43	42	possessing	possess	VERB
brainmatters-882	43	43	no	no	DET
brainmatters-882	43	44	contribution	contribution	NOUN
brainmatters-882	43	45	to	to	ADP
brainmatters-882	43	46	the	the	DET
brainmatters-882	43	47	treatment	treatment	NOUN
brainmatters-882	43	48	and	and	CCONJ
brainmatters-882	43	49	root	root	NOUN
brainmatters-882	43	50	cause	cause	NOUN
brainmatters-882	43	51	of	of	ADP
brainmatters-882	43	52	alzheimers	alzheimer	NOUN
brainmatters-882	43	53	.	.	PUNCT
brainmatters-882	44	1	endoplasmic	endoplasmic	ADJ
brainmatters-882	44	2	reticulum	reticulum	NOUN
brainmatters-882	44	3	(	(	PUNCT
brainmatters-882	44	4	er	er	INTJ
brainmatters-882	44	5	)	)	PUNCT
brainmatters-882	44	6	stress	stress	NOUN
brainmatters-882	44	7	and	and	CCONJ
brainmatters-882	44	8	the	the	DET
brainmatters-882	44	9	unfolded	unfolded	ADJ
brainmatters-882	44	10	protein	protein	NOUN
brainmatters-882	44	11	response	response	NOUN
brainmatters-882	44	12	(	(	PUNCT
brainmatters-882	44	13	upr	upr	NOUN
brainmatters-882	44	14	)	)	PUNCT
brainmatters-882	44	15	has	have	AUX
brainmatters-882	44	16	been	be	AUX
brainmatters-882	44	17	extensively	extensively	ADV
brainmatters-882	44	18	studied	study	VERB
brainmatters-882	44	19	,	,	PUNCT
brainmatters-882	44	20	as	as	SCONJ
brainmatters-882	44	21	the	the	DET
brainmatters-882	44	22	majority	majority	NOUN
brainmatters-882	44	23	of	of	ADP
brainmatters-882	44	24	neurodegenerative	neurodegenerative	ADJ
brainmatters-882	44	25	diseases	disease	NOUN
brainmatters-882	44	26	are	be	AUX
brainmatters-882	44	27	correlated	correlate	VERB
brainmatters-882	44	28	with	with	ADP
brainmatters-882	44	29	an	an	DET
brainmatters-882	44	30	accumulation	accumulation	NOUN
brainmatters-882	44	31	of	of	ADP
brainmatters-882	44	32	misfolded	misfolde	VERB
brainmatters-882	44	33	proteins	protein	NOUN
brainmatters-882	44	34	,	,	PUNCT
brainmatters-882	44	35	which	which	PRON
brainmatters-882	44	36	contributes	contribute	VERB
brainmatters-882	44	37	to	to	ADP
brainmatters-882	44	38	stress	stress	NOUN
brainmatters-882	44	39	and	and	CCONJ
brainmatters-882	44	40	eventual	eventual	ADJ
brainmatters-882	44	41	breakdown	breakdown	NOUN
brainmatters-882	44	42	of	of	ADP
brainmatters-882	44	43	the	the	DET
brainmatters-882	44	44	er	er	INTJ
brainmatters-882	44	45	.	.	PUNCT
brainmatters-882	45	1	additionally	additionally	ADV
brainmatters-882	45	2	,	,	PUNCT
brainmatters-882	45	3	beta	beta	NOUN
brainmatters-882	45	4	-	-	PUNCT
brainmatters-882	45	5	amyloid	amyloid	NOUN
brainmatters-882	45	6	oligomers	oligomer	NOUN
brainmatters-882	45	7	are	be	AUX
brainmatters-882	45	8	a	a	DET
brainmatters-882	45	9	source	source	NOUN
brainmatters-882	45	10	of	of	ADP
brainmatters-882	45	11	destabilization	destabilization	NOUN
brainmatters-882	45	12	to	to	ADP
brainmatters-882	45	13	the	the	DET
brainmatters-882	45	14	calcium	calcium	NOUN
brainmatters-882	45	15	of	of	ADP
brainmatters-882	45	16	the	the	DET
brainmatters-882	45	17	er	er	INTJ
brainmatters-882	45	18	and	and	CCONJ
brainmatters-882	45	19	its	its	PRON
brainmatters-882	45	20	homeostasis	homeostasis	NOUN
brainmatters-882	45	21	,	,	PUNCT
brainmatters-882	45	22	resulting	result	VERB
brainmatters-882	45	23	in	in	ADP
brainmatters-882	45	24	the	the	DET
brainmatters-882	45	25	death	death	NOUN
brainmatters-882	45	26	of	of	ADP
brainmatters-882	45	27	neurons	neuron	NOUN
brainmatters-882	45	28	.	.	PUNCT
brainmatters-882	46	1	by	by	ADP
brainmatters-882	46	2	potentially	potentially	ADV
brainmatters-882	46	3	being	be	AUX
brainmatters-882	46	4	able	able	ADJ
brainmatters-882	46	5	to	to	PART
brainmatters-882	46	6	reduce	reduce	VERB
brainmatters-882	46	7	the	the	DET
brainmatters-882	46	8	amount	amount	NOUN
brainmatters-882	46	9	of	of	ADP
brainmatters-882	46	10	stress	stress	NOUN
brainmatters-882	46	11	affecting	affect	VERB
brainmatters-882	46	12	the	the	DET
brainmatters-882	46	13	er	er	INTJ
brainmatters-882	46	14	,	,	PUNCT
brainmatters-882	46	15	researchers	researcher	NOUN
brainmatters-882	46	16	have	have	AUX
brainmatters-882	46	17	begun	begin	VERB
brainmatters-882	46	18	to	to	PART
brainmatters-882	46	19	experiment	experiment	VERB
brainmatters-882	46	20	with	with	ADP
brainmatters-882	46	21	a	a	DET
brainmatters-882	46	22	method	method	NOUN
brainmatters-882	46	23	to	to	PART
brainmatters-882	46	24	target	target	VERB
brainmatters-882	46	25	the	the	DET
brainmatters-882	46	26	unfolded	unfold	VERB
brainmatters-882	46	27	protein	protein	NOUN
brainmatters-882	46	28	response	response	NOUN
brainmatters-882	46	29	(	(	PUNCT
brainmatters-882	46	30	upr	upr	NOUN
brainmatters-882	46	31	)	)	PUNCT
brainmatters-882	46	32	signaling	signal	VERB
brainmatters-882	46	33	in	in	ADP
brainmatters-882	46	34	the	the	DET
brainmatters-882	46	35	hopes	hope	NOUN
brainmatters-882	46	36	that	that	SCONJ
brainmatters-882	46	37	the	the	DET
brainmatters-882	46	38	signaling	signal	VERB
brainmatters-882	46	39	pathway	pathway	NOUN
brainmatters-882	46	40	may	may	AUX
brainmatters-882	46	41	be	be	AUX
brainmatters-882	46	42	amplified	amplify	VERB
brainmatters-882	46	43	for	for	ADP
brainmatters-882	46	44	improvement	improvement	NOUN
brainmatters-882	46	45	in	in	ADP
brainmatters-882	46	46	protein	protein	NOUN
brainmatters-882	46	47	folding	fold	VERB
brainmatters-882	46	48	through	through	ADP
brainmatters-882	46	49	gene	gene	NOUN
brainmatters-882	46	50	editing	editing	NOUN
brainmatters-882	46	51	.	.	PUNCT
brainmatters-882	47	1	notably	notably	ADV
brainmatters-882	47	2	,	,	PUNCT
brainmatters-882	47	3	a	a	DET
brainmatters-882	47	4	positive	positive	ADJ
brainmatters-882	47	5	correlation	correlation	NOUN
brainmatters-882	47	6	between	between	ADP
brainmatters-882	47	7	the	the	DET
brainmatters-882	47	8	overregulation	overregulation	NOUN
brainmatters-882	47	9	of	of	ADP
brainmatters-882	47	10	the	the	DET
brainmatters-882	47	11	upr	upr	ADJ
brainmatters-882	47	12	pathway	pathway	NOUN
brainmatters-882	47	13	and	and	CCONJ
brainmatters-882	47	14	glioblastoma	glioblastoma	NOUN
brainmatters-882	47	15	invasion	invasion	NOUN
brainmatters-882	47	16	has	have	AUX
brainmatters-882	47	17	been	be	AUX
brainmatters-882	47	18	discovered	discover	VERB
brainmatters-882	47	19	,	,	PUNCT
brainmatters-882	47	20	therefore	therefore	ADV
brainmatters-882	47	21	being	be	AUX
brainmatters-882	47	22	a	a	DET
brainmatters-882	47	23	safety	safety	NOUN
brainmatters-882	47	24	concern	concern	NOUN
brainmatters-882	47	25	when	when	SCONJ
brainmatters-882	47	26	experimenting	experiment	VERB
brainmatters-882	47	27	with	with	ADP
brainmatters-882	47	28	this	this	DET
brainmatters-882	47	29	pathway	pathway	NOUN
brainmatters-882	47	30	.	.	PUNCT
brainmatters-882	48	1	another	another	DET
brainmatters-882	48	2	potential	potential	ADJ
brainmatters-882	48	3	target	target	NOUN
brainmatters-882	48	4	for	for	ADP
brainmatters-882	48	5	researchers	researcher	NOUN
brainmatters-882	48	6	has	have	AUX
brainmatters-882	48	7	been	be	AUX
brainmatters-882	48	8	the	the	DET
brainmatters-882	48	9	mtor	mtor	PROPN
brainmatters-882	48	10	pathway	pathway	NOUN
brainmatters-882	48	11	,	,	PUNCT
brainmatters-882	48	12	which	which	PRON
brainmatters-882	48	13	deals	deal	VERB
brainmatters-882	48	14	with	with	ADP
brainmatters-882	48	15	the	the	DET
brainmatters-882	48	16	regulation	regulation	NOUN
brainmatters-882	48	17	of	of	ADP
brainmatters-882	48	18	mammalian	mammalian	ADJ
brainmatters-882	48	19	metabolism	metabolism	NOUN
brainmatters-882	48	20	and	and	CCONJ
brainmatters-882	48	21	has	have	AUX
brainmatters-882	48	22	also	also	ADV
brainmatters-882	48	23	been	be	AUX
brainmatters-882	48	24	known	know	VERB
brainmatters-882	48	25	to	to	PART
brainmatters-882	48	26	play	play	VERB
brainmatters-882	48	27	a	a	DET
brainmatters-882	48	28	role	role	NOUN
brainmatters-882	48	29	in	in	ADP
brainmatters-882	48	30	neurodegeneration	neurodegeneration	NOUN
brainmatters-882	48	31	;	;	PUNCT
brainmatters-882	48	32	when	when	SCONJ
brainmatters-882	48	33	being	be	AUX
brainmatters-882	48	34	abnormally	abnormally	ADV
brainmatters-882	48	35	regulated	regulate	VERB
brainmatters-882	48	36	,	,	PUNCT
brainmatters-882	48	37	protein	protein	NOUN
brainmatters-882	48	38	accumulation	accumulation	NOUN
brainmatters-882	48	39	is	be	AUX
brainmatters-882	48	40	unable	unable	ADJ
brainmatters-882	48	41	to	to	PART
brainmatters-882	48	42	be	be	AUX
brainmatters-882	48	43	removed	remove	VERB
brainmatters-882	48	44	.	.	PUNCT
brainmatters-882	49	1	in	in	ADP
brainmatters-882	49	2	2017	2017	NUM
brainmatters-882	49	3	,	,	PUNCT
brainmatters-882	49	4	chen	chen	PROPN
brainmatters-882	49	5	et	et	PROPN
brainmatters-882	49	6	.	.	PUNCT
brainmatters-882	50	1	al	al	PROPN
brainmatters-882	50	2	previously	previously	ADV
brainmatters-882	50	3	demonstrated	demonstrate	VERB
brainmatters-882	50	4	that	that	SCONJ
brainmatters-882	50	5	the	the	DET
brainmatters-882	50	6	delivery	delivery	NOUN
brainmatters-882	50	7	of	of	ADP
brainmatters-882	50	8	mtor	mtor	PROPN
brainmatters-882	50	9	positive	positive	ADJ
brainmatters-882	50	10	regulators	regulator	NOUN
brainmatters-882	50	11	to	to	ADP
brainmatters-882	50	12	the	the	DET
brainmatters-882	50	13	retina	retina	NOUN
brainmatters-882	50	14	via	via	ADP
brainmatters-882	50	15	the	the	DET
brainmatters-882	50	16	aav	aav	PROPN
brainmatters-882	50	17	vector	vector	NOUN
brainmatters-882	50	18	resulted	result	VERB
brainmatters-882	50	19	in	in	ADP
brainmatters-882	50	20	a	a	DET
brainmatters-882	50	21	decrease	decrease	NOUN
brainmatters-882	50	22	of	of	ADP
brainmatters-882	50	23	ganglion	ganglion	NOUN
brainmatters-882	50	24	cell	cell	NOUN
brainmatters-882	50	25	death	death	NOUN
brainmatters-882	50	26	and	and	CCONJ
brainmatters-882	50	27	cns	cns	PROPN
brainmatters-882	50	28	axon	axon	NOUN
brainmatters-882	50	29	regeneration	regeneration	NOUN
brainmatters-882	50	30	;	;	PUNCT
brainmatters-882	50	31	a	a	DET
brainmatters-882	50	32	variety	variety	NOUN
brainmatters-882	50	33	of	of	ADP
brainmatters-882	50	34	other	other	ADJ
brainmatters-882	50	35	studies	study	NOUN
brainmatters-882	50	36	have	have	AUX
brainmatters-882	50	37	also	also	ADV
brainmatters-882	50	38	reported	report	VERB
brainmatters-882	50	39	positive	positive	ADJ
brainmatters-882	50	40	effects	effect	NOUN
brainmatters-882	50	41	on	on	ADP
brainmatters-882	50	42	neuron	neuron	NOUN
brainmatters-882	50	43	regeneration	regeneration	NOUN
brainmatters-882	50	44	in	in	ADP
brainmatters-882	50	45	mouse	mouse	NOUN
brainmatters-882	50	46	models	model	NOUN
brainmatters-882	50	47	,	,	PUNCT
brainmatters-882	50	48	highlighting	highlight	VERB
brainmatters-882	50	49	the	the	DET
brainmatters-882	50	50	potential	potential	NOUN
brainmatters-882	50	51	for	for	SCONJ
brainmatters-882	50	52	the	the	DET
brainmatters-882	50	53	mtor	mtor	PROPN
brainmatters-882	50	54	pathway	pathway	NOUN
brainmatters-882	50	55	to	to	PART
brainmatters-882	50	56	be	be	AUX
brainmatters-882	50	57	an	an	DET
brainmatters-882	50	58	ideal	ideal	ADJ
brainmatters-882	50	59	target	target	NOUN
brainmatters-882	50	60	.	.	PUNCT
brainmatters-882	51	1	researchers	researcher	NOUN
brainmatters-882	51	2	have	have	AUX
brainmatters-882	51	3	also	also	ADV
brainmatters-882	51	4	devised	devise	VERB
brainmatters-882	51	5	methods	method	NOUN
brainmatters-882	51	6	for	for	ADP
brainmatters-882	51	7	autophagy	autophagy	NOUN
brainmatters-882	51	8	to	to	PART
brainmatters-882	51	9	be	be	AUX
brainmatters-882	51	10	used	use	VERB
brainmatters-882	51	11	through	through	ADP
brainmatters-882	51	12	gene	gene	NOUN
brainmatters-882	51	13	editing	editing	NOUN
brainmatters-882	51	14	;	;	PUNCT
brainmatters-882	51	15	in	in	ADP
brainmatters-882	51	16	2012	2012	NUM
brainmatters-882	51	17	,	,	PUNCT
brainmatters-882	51	18	gorbatyuk	gorbatyuk	PROPN
brainmatters-882	51	19	et	et	PROPN
brainmatters-882	51	20	.	.	PUNCT
brainmatters-882	52	1	al	al	PROPN
brainmatters-882	52	2	demonstrated	demonstrate	VERB
brainmatters-882	52	3	that	that	SCONJ
brainmatters-882	52	4	the	the	DET
brainmatters-882	52	5	overexpression	overexpression	NOUN
brainmatters-882	52	6	of	of	ADP
brainmatters-882	52	7	a	a	DET
brainmatters-882	52	8	kinase	kinase	NOUN
brainmatters-882	52	9	through	through	ADP
brainmatters-882	52	10	aav2	aav2	PROPN
brainmatters-882	52	11	resulted	result	VERB
brainmatters-882	52	12	in	in	ADP
brainmatters-882	52	13	the	the	DET
brainmatters-882	52	14	autophagy	autophagy	NOUN
brainmatters-882	52	15	of	of	ADP
brainmatters-882	52	16	dysfunctional	dysfunctional	ADJ
brainmatters-882	52	17	mitochondria	mitochondria	NOUN
brainmatters-882	52	18	.	.	PUNCT
brainmatters-882	53	1	in	in	ADP
brainmatters-882	53	2	doing	do	VERB
brainmatters-882	53	3	so	so	ADV
brainmatters-882	53	4	,	,	PUNCT
brainmatters-882	53	5	mitochondrial	mitochondrial	ADJ
brainmatters-882	53	6	function	function	NOUN
brainmatters-882	53	7	that	that	PRON
brainmatters-882	53	8	was	be	AUX
brainmatters-882	53	9	lost	lose	VERB
brainmatters-882	53	10	as	as	ADP
brainmatters-882	53	11	a	a	DET
brainmatters-882	53	12	result	result	NOUN
brainmatters-882	53	13	of	of	ADP
brainmatters-882	53	14	b	b	NOUN
brainmatters-882	53	15	-	-	PUNCT
brainmatters-882	53	16	amyloid	amyloid	NOUN
brainmatters-882	53	17	oligomers	oligomer	NOUN
brainmatters-882	53	18	was	be	AUX
brainmatters-882	53	19	regained	regain	VERB
brainmatters-882	53	20	(	(	PUNCT
brainmatters-882	53	21	chen	chen	PROPN
brainmatters-882	53	22	et.al	et.al	PROPN
brainmatters-882	53	23	,	,	PUNCT
brainmatters-882	53	24	2020	2020	NUM
brainmatters-882	53	25	)	)	PUNCT
brainmatters-882	53	26	.	.	PUNCT
brainmatters-882	54	1	similarly	similarly	ADV
brainmatters-882	54	2	,	,	PUNCT
brainmatters-882	54	3	microglia	microglia	ADJ
brainmatters-882	54	4	and	and	CCONJ
brainmatters-882	54	5	astrocyte	astrocyte	NOUN
brainmatters-882	54	6	function	function	NOUN
brainmatters-882	54	7	has	have	AUX
brainmatters-882	54	8	been	be	AUX
brainmatters-882	54	9	brought	bring	VERB
brainmatters-882	54	10	to	to	ADP
brainmatters-882	54	11	light	light	NOUN
brainmatters-882	54	12	as	as	ADP
brainmatters-882	54	13	potential	potential	ADJ
brainmatters-882	54	14	targets	target	NOUN
brainmatters-882	54	15	,	,	PUNCT
brainmatters-882	54	16	considering	consider	VERB
brainmatters-882	54	17	the	the	DET
brainmatters-882	54	18	great	great	ADJ
brainmatters-882	54	19	importance	importance	NOUN
brainmatters-882	54	20	of	of	ADP
brainmatters-882	54	21	microglia	microglia	NOUN
brainmatters-882	54	22	within	within	ADP
brainmatters-882	54	23	the	the	DET
brainmatters-882	54	24	neuroimmune	neuroimmune	ADJ
brainmatters-882	54	25	system	system	NOUN
brainmatters-882	54	26	,	,	PUNCT
brainmatters-882	54	27	and	and	CCONJ
brainmatters-882	54	28	the	the	DET
brainmatters-882	54	29	damaging	damaging	NOUN
brainmatters-882	54	30	of	of	ADP
brainmatters-882	54	31	their	their	PRON
brainmatters-882	54	32	functions	function	NOUN
brainmatters-882	54	33	resulting	result	VERB
brainmatters-882	54	34	in	in	ADP
brainmatters-882	54	35	the	the	DET
brainmatters-882	54	36	neuron	neuron	NOUN
brainmatters-882	54	37	destruction	destruction	NOUN
brainmatters-882	54	38	witnessed	witness	VERB
brainmatters-882	54	39	in	in	ADP
brainmatters-882	54	40	alzheimers	alzheimer	NOUN
brainmatters-882	54	41	.	.	PUNCT
brainmatters-882	55	1	the	the	DET
brainmatters-882	55	2	re	re	NOUN
brainmatters-882	55	3	-	-	NOUN
brainmatters-882	55	4	regulation	regulation	NOUN
brainmatters-882	55	5	of	of	ADP
brainmatters-882	55	6	microglia	microglia	ADJ
brainmatters-882	55	7	function	function	NOUN
brainmatters-882	55	8	has	have	AUX
brainmatters-882	55	9	been	be	AUX
brainmatters-882	55	10	considered	consider	VERB
brainmatters-882	55	11	a	a	DET
brainmatters-882	55	12	potential	potential	ADJ
brainmatters-882	55	13	treatment	treatment	NOUN
brainmatters-882	55	14	;	;	PUNCT
brainmatters-882	55	15	multiple	multiple	ADJ
brainmatters-882	55	16	studies	study	NOUN
brainmatters-882	55	17	have	have	AUX
brainmatters-882	55	18	reviewed	review	VERB
brainmatters-882	55	19	the	the	DET
brainmatters-882	55	20	ability	ability	NOUN
brainmatters-882	55	21	of	of	ADP
brainmatters-882	55	22	the	the	DET
brainmatters-882	55	23	overexpression	overexpression	NOUN
brainmatters-882	55	24	of	of	ADP
brainmatters-882	55	25	the	the	DET
brainmatters-882	55	26	receptor	receptor	NOUN
brainmatters-882	55	27	trem2	trem2	NOUN
brainmatters-882	55	28	on	on	ADP
brainmatters-882	55	29	myeloids	myeloid	NOUN
brainmatters-882	55	30	to	to	PART
brainmatters-882	55	31	assist	assist	VERB
brainmatters-882	55	32	beta	beta	ADJ
brainmatters-882	55	33	amyloid	amyloid	NOUN
brainmatters-882	55	34	destruction	destruction	NOUN
brainmatters-882	55	35	and	and	CCONJ
brainmatters-882	55	36	microglial	microglial	ADJ
brainmatters-882	55	37	movement	movement	NOUN
brainmatters-882	55	38	.	.	PUNCT
brainmatters-882	56	1	through	through	ADP
brainmatters-882	56	2	this	this	DET
brainmatters-882	56	3	process	process	NOUN
brainmatters-882	56	4	,	,	PUNCT
brainmatters-882	56	5	the	the	DET
brainmatters-882	56	6	plaque	plaque	NOUN
brainmatters-882	56	7	formation	formation	NOUN
brainmatters-882	56	8	and	and	CCONJ
brainmatters-882	56	9	eventual	eventual	ADJ
brainmatters-882	56	10	disruption	disruption	NOUN
brainmatters-882	56	11	of	of	ADP
brainmatters-882	56	12	neurons	neuron	NOUN
brainmatters-882	56	13	caused	cause	VERB
brainmatters-882	56	14	by	by	ADP
brainmatters-882	56	15	bamyloids	bamyloid	NOUN
brainmatters-882	56	16	is	be	AUX
brainmatters-882	56	17	reduced	reduce	VERB
brainmatters-882	56	18	,	,	PUNCT
brainmatters-882	56	19	and	and	CCONJ
brainmatters-882	56	20	spatial	spatial	ADJ
brainmatters-882	56	21	memory	memory	NOUN
brainmatters-882	56	22	abilities	ability	NOUN
brainmatters-882	56	23	are	be	AUX
brainmatters-882	56	24	increased	increase	VERB
brainmatters-882	56	25	.	.	PUNCT
brainmatters-882	57	1	in	in	ADP
brainmatters-882	57	2	recent	recent	ADJ
brainmatters-882	57	3	years	year	NOUN
brainmatters-882	57	4	,	,	PUNCT
brainmatters-882	57	5	studies	study	NOUN
brainmatters-882	57	6	with	with	ADP
brainmatters-882	57	7	clustered	cluster	VERB
brainmatters-882	57	8	,	,	PUNCT
brainmatters-882	57	9	regularly	regularly	ADV
brainmatters-882	57	10	interspaced	interspace	VERB
brainmatters-882	57	11	short	short	ADJ
brainmatters-882	57	12	palindromic	palindromic	ADJ
brainmatters-882	57	13	repeats	repeat	NOUN
brainmatters-882	57	14	and	and	CCONJ
brainmatters-882	57	15	the	the	DET
brainmatters-882	57	16	crispr	crispr	NOUN
brainmatters-882	57	17	-	-	PUNCT
brainmatters-882	57	18	associated	associate	VERB
brainmatters-882	57	19	protein	protein	NOUN
brainmatters-882	57	20	9	9	NUM
brainmatters-882	57	21	(	(	PUNCT
brainmatters-882	57	22	crispr	crispr	NOUN
brainmatters-882	57	23	-	-	PUNCT
brainmatters-882	57	24	cas9	cas9	NOUN
brainmatters-882	57	25	)	)	PUNCT
brainmatters-882	57	26	have	have	AUX
brainmatters-882	57	27	increased	increase	VERB
brainmatters-882	57	28	significantly	significantly	ADV
brainmatters-882	57	29	,	,	PUNCT
brainmatters-882	57	30	and	and	CCONJ
brainmatters-882	57	31	yielded	yield	VERB
brainmatters-882	57	32	optimistic	optimistic	ADJ
brainmatters-882	57	33	results	result	NOUN
brainmatters-882	57	34	.	.	PUNCT
brainmatters-882	58	1	targeted	target	VERB
brainmatters-882	58	2	to	to	ADP
brainmatters-882	58	3	specific	specific	ADJ
brainmatters-882	58	4	genes	gene	NOUN
brainmatters-882	58	5	and	and	CCONJ
brainmatters-882	58	6	figure	figure	NOUN
brainmatters-882	58	7	1	1	NUM
brainmatters-882	58	8	.	.	PUNCT
brainmatters-882	58	9	proposed	propose	VERB
brainmatters-882	58	10	crispr	crispr	ADJ
brainmatters-882	58	11	cas-9	cas-9	PUNCT
brainmatters-882	58	12	gene	gene	NOUN
brainmatters-882	58	13	editing	edit	VERB
brainmatters-882	58	14	approaches	approach	NOUN
brainmatters-882	58	15	to	to	ADP
brainmatters-882	58	16	types	type	NOUN
brainmatters-882	58	17	of	of	ADP
brainmatters-882	58	18	alzheimer	alzheimer	PROPN
brainmatters-882	58	19	’s	’s	PART
brainmatters-882	58	20	disease	disease	NOUN
brainmatters-882	58	21	.	.	PUNCT
brainmatters-882	59	1	adapted	adapt	VERB
brainmatters-882	59	2	from	from	ADP
brainmatters-882	59	3	“	"	PUNCT
brainmatters-882	59	4	crispr	crispr	ADJ
brainmatters-882	59	5	-	-	PUNCT
brainmatters-882	59	6	cas9	cas9	NOUN
brainmatters-882	59	7	gene	gene	NOUN
brainmatters-882	59	8	editing	edit	VERB
brainmatters-882	59	9	:	:	PUNCT
brainmatters-882	59	10	new	new	ADJ
brainmatters-882	59	11	hope	hope	NOUN
brainmatters-882	59	12	for	for	ADP
brainmatters-882	59	13	alzheimer	alzheimer	PROPN
brainmatters-882	59	14	’s	’s	PART
brainmatters-882	59	15	disease	disease	NOUN
brainmatters-882	59	16	therapeutics	therapeutic	NOUN
brainmatters-882	59	17	,	,	PUNCT
brainmatters-882	59	18	”	"	PUNCT
brainmatters-882	59	19	by	by	ADP
brainmatters-882	59	20	bhardwaj	bhardwaj	PROPN
brainmatters-882	59	21	,	,	PUNCT
brainmatters-882	59	22	s.	s.	PROPN
brainmatters-882	59	23	et	et	PROPN
brainmatters-882	59	24	al	al	PROPN
brainmatters-882	59	25	,	,	PUNCT
brainmatters-882	59	26	2021	2021	NUM
brainmatters-882	59	27	,	,	PUNCT
brainmatters-882	59	28	journal	journal	NOUN
brainmatters-882	59	29	of	of	ADP
brainmatters-882	59	30	advanced	advanced	ADJ
brainmatters-882	59	31	research	research	NOUN
brainmatters-882	59	32	(	(	PUNCT
brainmatters-882	59	33	https://doi.org/10.1016/j.jare.2021.07.001	https://doi.org/10.1016/j.jare.2021.07.001	PROPN
brainmatters-882	59	34	)	)	PUNCT
brainmatters-882	59	35	.	.	PUNCT
brainmatters-882	60	1	cc	cc	VERB
brainmatters-882	60	2	by	by	ADP
brainmatters-882	60	3	4.0	4.0	NUM
brainmatters-882	60	4	.	.	PUNCT
brainmatters-882	60	5	13	13	NUM
brainmatters-882	60	6	bhardwaj	bhardwaj	PROPN
brainmatters-882	60	7	,	,	PUNCT
brainmatters-882	60	8	s.	s.	PROPN
brainmatters-882	60	9	,	,	PUNCT
brainmatters-882	60	10	kesari	kesari	PROPN
brainmatters-882	60	11	,	,	PUNCT
brainmatters-882	60	12	k.	k.	PROPN
brainmatters-882	60	13	k.	k.	PROPN
brainmatters-882	60	14	,	,	PUNCT
brainmatters-882	60	15	rachamalla	rachamalla	NOUN
brainmatters-882	60	16	,	,	PUNCT
brainmatters-882	60	17	m.	m.	NOUN
brainmatters-882	60	18	,	,	PUNCT
brainmatters-882	60	19	mani	mani	PROPN
brainmatters-882	60	20	,	,	PUNCT
brainmatters-882	60	21	s.	s.	PROPN
brainmatters-882	60	22	,	,	PUNCT
brainmatters-882	60	23	ashraf	ashraf	PROPN
brainmatters-882	60	24	,	,	PUNCT
brainmatters-882	60	25	g.	g.	PROPN
brainmatters-882	60	26	m.	m.	PROPN
brainmatters-882	60	27	,	,	PUNCT
brainmatters-882	60	28	jha	jha	PROPN
brainmatters-882	60	29	,	,	PUNCT
brainmatters-882	60	30	s.	s.	PROPN
brainmatters-882	60	31	k.	k.	PROPN
brainmatters-882	60	32	,	,	PUNCT
brainmatters-882	60	33	kumar	kumar	PROPN
brainmatters-882	60	34	,	,	PUNCT
brainmatters-882	60	35	p.	p.	PROPN
brainmatters-882	60	36	,	,	PUNCT
brainmatters-882	60	37	ambasta	ambasta	PROPN
brainmatters-882	60	38	,	,	PUNCT
brainmatters-882	60	39	r.	r.	PROPN
brainmatters-882	60	40	k.	k.	PROPN
brainmatters-882	60	41	,	,	PUNCT
brainmatters-882	60	42	dureja	dureja	PROPN
brainmatters-882	60	43	,	,	PUNCT
brainmatters-882	60	44	h.	h.	NOUN
brainmatters-882	60	45	,	,	PUNCT
brainmatters-882	60	46	devkota	devkota	NOUN
brainmatters-882	60	47	,	,	PUNCT
brainmatters-882	60	48	h.	h.	PROPN
brainmatters-882	60	49	p.	p.	PROPN
brainmatters-882	60	50	,	,	PUNCT
brainmatters-882	60	51	gupta	gupta	PROPN
brainmatters-882	60	52	,	,	PUNCT
brainmatters-882	60	53	g.	g.	PROPN
brainmatters-882	60	54	,	,	PUNCT
brainmatters-882	60	55	chellappan	chellappan	PROPN
brainmatters-882	60	56	,	,	PUNCT
brainmatters-882	60	57	d.	d.	PROPN
brainmatters-882	60	58	k.	k.	PROPN
brainmatters-882	60	59	,	,	PUNCT
brainmatters-882	60	60	singh	singh	PROPN
brainmatters-882	60	61	,	,	PUNCT
brainmatters-882	60	62	s.	s.	PROPN
brainmatters-882	60	63	k.	k.	PROPN
brainmatters-882	60	64	,	,	PUNCT
brainmatters-882	60	65	dua	dua	PROPN
brainmatters-882	60	66	,	,	PUNCT
brainmatters-882	60	67	k.	k.	PROPN
brainmatters-882	60	68	,	,	PUNCT
brainmatters-882	60	69	ruokolainen	ruokolainen	PROPN
brainmatters-882	60	70	,	,	PUNCT
brainmatters-882	60	71	j.	j.	PROPN
brainmatters-882	60	72	,	,	PUNCT
brainmatters-882	60	73	kamal	kamal	PROPN
brainmatters-882	60	74	,	,	PUNCT
brainmatters-882	60	75	m.	m.	NOUN
brainmatters-882	60	76	a.	a.	PROPN
brainmatters-882	60	77	,	,	PUNCT
brainmatters-882	60	78	ojha	ojha	PROPN
brainmatters-882	60	79	,	,	PUNCT
brainmatters-882	60	80	s.	s.	PROPN
brainmatters-882	60	81	,	,	PUNCT
brainmatters-882	60	82	&	&	CCONJ
brainmatters-882	60	83	jha	jha	PROPN
brainmatters-882	60	84	,	,	PUNCT
brainmatters-882	60	85	n.	n.	PROPN
brainmatters-882	60	86	k.	k.	PROPN
brainmatters-882	60	87	(	(	PUNCT
brainmatters-882	60	88	2021	2021	NUM
brainmatters-882	60	89	)	)	PUNCT
brainmatters-882	60	90	.	.	PUNCT
brainmatters-882	61	1	crispr	crispr	PROPN
brainmatters-882	61	2	/	/	SYM
brainmatters-882	61	3	cas9	cas9	NOUN
brainmatters-882	61	4	gene	gene	NOUN
brainmatters-882	61	5	editing	editing	NOUN
brainmatters-882	61	6	:	:	PUNCT
brainmatters-882	61	7	new	new	ADJ
brainmatters-882	61	8	hope	hope	NOUN
brainmatters-882	61	9	for	for	ADP
brainmatters-882	61	10	alzheimer	alzheimer	PROPN
brainmatters-882	61	11	's	's	PART
brainmatters-882	61	12	disease	disease	NOUN
brainmatters-882	61	13	therapeutics	therapeutic	NOUN
brainmatters-882	61	14	.	.	PUNCT
brainmatters-882	62	1	journal	journal	NOUN
brainmatters-882	62	2	of	of	ADP
brainmatters-882	62	3	advanced	advanced	ADJ
brainmatters-882	62	4	research	research	NOUN
brainmatters-882	62	5	.	.	PUNCT
brainmatters-882	63	1	https://doi.org/10.1016/j.jare.2021.07.001	https://doi.org/10.1016/j.jare.2021.07.001	PROPN
brainmatters-882	63	2	chen	chen	PROPN
brainmatters-882	63	3	,	,	PUNCT
brainmatters-882	63	4	w.	w.	PROPN
brainmatters-882	63	5	,	,	PUNCT
brainmatters-882	63	6	hu	hu	PROPN
brainmatters-882	63	7	,	,	PUNCT
brainmatters-882	63	8	y.	y.	PROPN
brainmatters-882	63	9	,	,	PUNCT
brainmatters-882	63	10	&	&	CCONJ
brainmatters-882	63	11	ju	ju	PROPN
brainmatters-882	63	12	,	,	PUNCT
brainmatters-882	63	13	d.	d.	PROPN
brainmatters-882	63	14	(	(	PUNCT
brainmatters-882	63	15	2020	2020	NUM
brainmatters-882	63	16	)	)	PUNCT
brainmatters-882	63	17	.	.	PUNCT
brainmatters-882	64	1	gene	gene	NOUN
brainmatters-882	64	2	therapy	therapy	NOUN
brainmatters-882	64	3	for	for	ADP
brainmatters-882	64	4	neurodegenerative	neurodegenerative	ADJ
brainmatters-882	64	5	disorders	disorder	NOUN
brainmatters-882	64	6	:	:	PUNCT
brainmatters-882	64	7	advances	advance	NOUN
brainmatters-882	64	8	,	,	PUNCT
brainmatters-882	64	9	insights	insight	NOUN
brainmatters-882	64	10	and	and	CCONJ
brainmatters-882	64	11	prospects	prospect	NOUN
brainmatters-882	64	12	.	.	PUNCT
brainmatters-882	65	1	acta	acta	PROPN
brainmatters-882	65	2	pharmaceutica	pharmaceutica	PROPN
brainmatters-882	65	3	sinica	sinica	PROPN
brainmatters-882	65	4	b	b	PROPN
brainmatters-882	65	5	,	,	PUNCT
brainmatters-882	65	6	10(8	10(8	NOUN
brainmatters-882	65	7	)	)	PUNCT
brainmatters-882	65	8	,	,	PUNCT
brainmatters-882	65	9	1347	1347	NUM
brainmatters-882	65	10	–	–	PUNCT
brainmatters-882	65	11	1359	1359	NUM
brainmatters-882	65	12	.	.	PUNCT
brainmatters-882	66	1	https://doi.org/10.1016/j.apsb.2020.01.015	https://doi.org/10.1016/j.apsb.2020.01.015	PROPN
brainmatters-882	66	2	gaj	gaj	PROPN
brainmatters-882	66	3	,	,	PUNCT
brainmatters-882	66	4	t.	t.	PROPN
brainmatters-882	66	5	,	,	PUNCT
brainmatters-882	66	6	sirk	sirk	PROPN
brainmatters-882	66	7	,	,	PUNCT
brainmatters-882	66	8	s.	s.	PROPN
brainmatters-882	66	9	j.	j.	PROPN
brainmatters-882	66	10	,	,	PUNCT
brainmatters-882	66	11	shui	shui	PROPN
brainmatters-882	66	12	,	,	PUNCT
brainmatters-882	66	13	s.-lan	s.-lan	PROPN
brainmatters-882	66	14	,	,	PUNCT
brainmatters-882	66	15	&	&	CCONJ
brainmatters-882	66	16	liu	liu	PROPN
brainmatters-882	66	17	,	,	PUNCT
brainmatters-882	66	18	j.	j.	PROPN
brainmatters-882	66	19	(	(	PUNCT
brainmatters-882	66	20	2016	2016	NUM
brainmatters-882	66	21	)	)	PUNCT
brainmatters-882	66	22	.	.	PUNCT
brainmatters-882	67	1	genome	genome	NOUN
brainmatters-882	67	2	-	-	PUNCT
brainmatters-882	67	3	editing	edit	VERB
brainmatters-882	67	4	technologies	technology	NOUN
brainmatters-882	67	5	:	:	PUNCT
brainmatters-882	67	6	principles	principle	NOUN
brainmatters-882	67	7	and	and	CCONJ
brainmatters-882	67	8	applications	application	NOUN
brainmatters-882	67	9	.	.	PUNCT
brainmatters-882	68	1	cold	cold	ADJ
brainmatters-882	68	2	spring	spring	NOUN
brainmatters-882	68	3	harbor	harbor	NOUN
brainmatters-882	68	4	perspectives	perspective	NOUN
brainmatters-882	68	5	in	in	ADP
brainmatters-882	68	6	biology	biology	NOUN
brainmatters-882	68	7	,	,	PUNCT
brainmatters-882	68	8	8(12	8(12	NUM
brainmatters-882	68	9	)	)	PUNCT
brainmatters-882	68	10	.	.	PUNCT
brainmatters-882	69	1	https://doi.org/10.1101/cshperspect.a023754	https://doi.org/10.1101/cshperspect.a023754	PROPN
brainmatters-882	69	2	warnock	warnock	PROPN
brainmatters-882	69	3	,	,	PUNCT
brainmatters-882	69	4	j.	j.	PROPN
brainmatters-882	69	5	n.	n.	PROPN
brainmatters-882	69	6	,	,	PUNCT
brainmatters-882	69	7	daigre	daigre	PROPN
brainmatters-882	69	8	,	,	PUNCT
brainmatters-882	69	9	c.	c.	PROPN
brainmatters-882	69	10	,	,	PUNCT
brainmatters-882	69	11	&	&	CCONJ
brainmatters-882	69	12	al	al	PROPN
brainmatters-882	69	13	-	-	PUNCT
brainmatters-882	69	14	rubeai	rubeai	PROPN
brainmatters-882	69	15	,	,	PUNCT
brainmatters-882	69	16	m.	m.	NOUN
brainmatters-882	69	17	(	(	PUNCT
brainmatters-882	69	18	2011	2011	NUM
brainmatters-882	69	19	)	)	PUNCT
brainmatters-882	69	20	.	.	PUNCT
brainmatters-882	70	1	introduction	introduction	NOUN
brainmatters-882	70	2	to	to	ADP
brainmatters-882	70	3	viral	viral	ADJ
brainmatters-882	70	4	vectors	vector	NOUN
brainmatters-882	70	5	.	.	PUNCT
brainmatters-882	71	1	methods	method	NOUN
brainmatters-882	71	2	in	in	ADP
brainmatters-882	71	3	molecular	molecular	ADJ
brainmatters-882	71	4	biology	biology	NOUN
brainmatters-882	71	5	,	,	PUNCT
brainmatters-882	71	6	1–25	1–25	PROPN
brainmatters-882	71	7	.	.	PUNCT
brainmatters-882	72	1	https://doi.org/10.1007/978-1-61779-0959_1	https://doi.org/10.1007/978-1-61779-0959_1	PROPN
brainmatters-882	72	2	u.s	u.s	PROPN
brainmatters-882	72	3	.	.	PROPN
brainmatters-882	72	4	department	department	PROPN
brainmatters-882	72	5	of	of	ADP
brainmatters-882	72	6	health	health	PROPN
brainmatters-882	72	7	and	and	CCONJ
brainmatters-882	72	8	human	human	ADJ
brainmatters-882	72	9	services	service	NOUN
brainmatters-882	72	10	.	.	PUNCT
brainmatters-882	73	1	(	(	PUNCT
brainmatters-882	73	2	n.d	n.d	PROPN
brainmatters-882	73	3	.	.	PROPN
brainmatters-882	73	4	)	)	PUNCT
brainmatters-882	73	5	.	.	PUNCT
brainmatters-882	74	1	what	what	PRON
brainmatters-882	74	2	happens	happen	VERB
brainmatters-882	74	3	to	to	ADP
brainmatters-882	74	4	the	the	DET
brainmatters-882	74	5	brain	brain	NOUN
brainmatters-882	74	6	in	in	ADP
brainmatters-882	74	7	alzheimer	alzheimer	PROPN
brainmatters-882	74	8	's	's	PART
brainmatters-882	74	9	disease	disease	NOUN
brainmatters-882	74	10	?	?	PUNCT
brainmatters-882	75	1	national	national	PROPN
brainmatters-882	75	2	institute	institute	PROPN
brainmatters-882	75	3	on	on	ADP
brainmatters-882	75	4	aging	aging	NOUN
brainmatters-882	75	5	.	.	PUNCT
brainmatters-882	76	1	retrieved	retrieve	VERB
brainmatters-882	76	2	april	april	PROPN
brainmatters-882	76	3	25	25	NUM
brainmatters-882	76	4	,	,	PUNCT
brainmatters-882	76	5	2022	2022	NUM
brainmatters-882	76	6	,	,	PUNCT
brainmatters-882	76	7	from	from	ADP
brainmatters-882	76	8	https://www.nia.nih.gov/health/what-happens-brainalzheimers-disease	https://www.nia.nih.gov/health/what-happens-brainalzheimers-disease	NOUN
brainmatters-882	76	9	references	reference	NOUN
brainmatters-882	76	10	1	1	NUM
brainmatters-882	76	11	.	.	NOUN
brainmatters-882	76	12	2	2	NUM
brainmatters-882	76	13	.	.	NOUN
brainmatters-882	76	14	3	3	NUM
brainmatters-882	76	15	.	.	NOUN
brainmatters-882	76	16	4	4	NUM
brainmatters-882	76	17	.	.	NOUN
brainmatters-882	76	18	5	5	NUM
brainmatters-882	76	19	.	.	X
brainmatters-882	76	20	14brain	14brain	NUM
brainmatters-882	77	1	matters	matter	NOUN
brainmatters-882	77	2	volume	volume	NOUN
brainmatters-882	77	3	vi	vi	PROPN