id	sid	tid	token	lemma	pos
brainmatters-990	1	1	volume	volume	NOUN
brainmatters-990	1	2	8	8	NUM
brainmatters-990	1	3	(	(	PUNCT
brainmatters-990	1	4	will	will	AUX
brainmatters-990	1	5	be	be	AUX
brainmatters-990	1	6	vol	vol	NOUN
brainmatters-990	1	7	7	7	NUM
brainmatters-990	1	8	on	on	ADP
brainmatters-990	1	9	site	site	NOUN
brainmatters-990	1	10	)	)	PUNCT
brainmatters-990	1	11	revolutionizing	revolutionize	VERB
brainmatters-990	1	12	treatment	treatment	NOUN
brainmatters-990	1	13	:	:	PUNCT
brainmatters-990	1	14	gene	gene	NOUN
brainmatters-990	1	15	therapy	therapy	NOUN
brainmatters-990	1	16	offers	offer	VERB
brainmatters-990	1	17	hope	hope	NOUN
brainmatters-990	1	18	for	for	ADP
brainmatters-990	1	19	hurler	hurler	PROPN
brainmatters-990	1	20	syndrome	syndrome	PROPN
brainmatters-990	1	21	krisha	krisha	PROPN
brainmatters-990	1	22	agarwal	agarwal	PROPN
brainmatters-990	1	23	abstract	abstract	ADJ
brainmatters-990	1	24	hurler	hurler	NOUN
brainmatters-990	1	25	syndrome	syndrome	NOUN
brainmatters-990	1	26	,	,	PUNCT
brainmatters-990	1	27	also	also	ADV
brainmatters-990	1	28	known	know	VERB
brainmatters-990	1	29	as	as	ADP
brainmatters-990	1	30	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
brainmatters-990	1	31	type	type	NOUN
brainmatters-990	1	32	i	i	PRON
brainmatters-990	1	33	(	(	PUNCT
brainmatters-990	1	34	mps	mps	PROPN
brainmatters-990	1	35	i	i	PROPN
brainmatters-990	1	36	)	)	PUNCT
brainmatters-990	1	37	,	,	PUNCT
brainmatters-990	1	38	is	be	AUX
brainmatters-990	1	39	a	a	DET
brainmatters-990	1	40	rare	rare	ADJ
brainmatters-990	1	41	lysosomal	lysosomal	ADJ
brainmatters-990	1	42	disorder	disorder	NOUN
brainmatters-990	1	43	wherein	wherein	SCONJ
brainmatters-990	1	44	genetic	genetic	ADJ
brainmatters-990	1	45	mutations	mutation	NOUN
brainmatters-990	1	46	prevent	prevent	VERB
brainmatters-990	1	47	the	the	DET
brainmatters-990	1	48	synthesis	synthesis	NOUN
brainmatters-990	1	49	of	of	ADP
brainmatters-990	1	50	enzyme	enzyme	NOUN
brainmatters-990	1	51	idua	idua	NOUN
brainmatters-990	1	52	,	,	PUNCT
brainmatters-990	1	53	disrupting	disrupt	VERB
brainmatters-990	1	54	the	the	DET
brainmatters-990	1	55	breakdown	breakdown	NOUN
brainmatters-990	1	56	of	of	ADP
brainmatters-990	1	57	sugar	sugar	NOUN
brainmatters-990	1	58	molecules	molecule	NOUN
brainmatters-990	1	59	.	.	PUNCT
brainmatters-990	2	1	this	this	DET
brainmatters-990	2	2	autosomal	autosomal	ADJ
brainmatters-990	2	3	recessive	recessive	ADJ
brainmatters-990	2	4	condition	condition	NOUN
brainmatters-990	2	5	targets	target	NOUN
brainmatters-990	2	6	newborns	newborn	NOUN
brainmatters-990	2	7	and	and	CCONJ
brainmatters-990	2	8	causes	cause	VERB
brainmatters-990	2	9	physical	physical	ADJ
brainmatters-990	2	10	and	and	CCONJ
brainmatters-990	2	11	cognitive	cognitive	ADJ
brainmatters-990	2	12	abnormalities	abnormality	NOUN
brainmatters-990	2	13	,	,	PUNCT
brainmatters-990	2	14	potentially	potentially	ADV
brainmatters-990	2	15	resulting	result	VERB
brainmatters-990	2	16	in	in	ADP
brainmatters-990	2	17	brain	brain	NOUN
brainmatters-990	2	18	damage	damage	NOUN
brainmatters-990	2	19	(	(	PUNCT
brainmatters-990	2	20	cleveland	cleveland	PROPN
brainmatters-990	2	21	clinic	clinic	PROPN
brainmatters-990	2	22	,	,	PUNCT
brainmatters-990	2	23	2022	2022	NUM
brainmatters-990	2	24	)	)	PUNCT
brainmatters-990	2	25	.	.	PUNCT
brainmatters-990	3	1	current	current	ADJ
brainmatters-990	3	2	treatments	treatment	NOUN
brainmatters-990	3	3	include	include	VERB
brainmatters-990	3	4	bone	bone	NOUN
brainmatters-990	3	5	marrow	marrow	NOUN
brainmatters-990	3	6	transplants	transplant	NOUN
brainmatters-990	3	7	,	,	PUNCT
brainmatters-990	3	8	which	which	PRON
brainmatters-990	3	9	are	be	AUX
brainmatters-990	3	10	not	not	PART
brainmatters-990	3	11	only	only	ADV
brainmatters-990	3	12	dangerous	dangerous	ADJ
brainmatters-990	3	13	but	but	CCONJ
brainmatters-990	3	14	also	also	ADV
brainmatters-990	3	15	an	an	DET
brainmatters-990	3	16	unfavorable	unfavorable	ADJ
brainmatters-990	3	17	solution	solution	NOUN
brainmatters-990	3	18	for	for	ADP
brainmatters-990	3	19	progressive	progressive	ADJ
brainmatters-990	3	20	brain	brain	NOUN
brainmatters-990	3	21	damage	damage	NOUN
brainmatters-990	3	22	.	.	PUNCT
brainmatters-990	4	1	recently	recently	ADV
brainmatters-990	4	2	,	,	PUNCT
brainmatters-990	4	3	a	a	DET
brainmatters-990	4	4	new	new	ADJ
brainmatters-990	4	5	form	form	NOUN
brainmatters-990	4	6	of	of	ADP
brainmatters-990	4	7	gene	gene	NOUN
brainmatters-990	4	8	therapy	therapy	NOUN
brainmatters-990	4	9	,	,	PUNCT
brainmatters-990	4	10	proprietary	proprietary	ADJ
brainmatters-990	4	11	system	system	NOUN
brainmatters-990	4	12	(	(	PUNCT
brainmatters-990	4	13	ps	ps	NOUN
brainmatters-990	4	14	)	)	PUNCT
brainmatters-990	4	15	gene	gene	NOUN
brainmatters-990	4	16	editing	editing	NOUN
brainmatters-990	4	17	,	,	PUNCT
brainmatters-990	4	18	has	have	AUX
brainmatters-990	4	19	shown	show	VERB
brainmatters-990	4	20	promising	promising	ADJ
brainmatters-990	4	21	results	result	NOUN
brainmatters-990	4	22	in	in	ADP
brainmatters-990	4	23	mice	mouse	NOUN
brainmatters-990	4	24	as	as	ADP
brainmatters-990	4	25	a	a	DET
brainmatters-990	4	26	treatment	treatment	NOUN
brainmatters-990	4	27	method	method	NOUN
brainmatters-990	4	28	,	,	PUNCT
brainmatters-990	4	29	as	as	SCONJ
brainmatters-990	4	30	concluded	conclude	VERB
brainmatters-990	4	31	by	by	ADP
brainmatters-990	4	32	researchers	researcher	NOUN
brainmatters-990	4	33	at	at	ADP
brainmatters-990	4	34	the	the	DET
brainmatters-990	4	35	university	university	PROPN
brainmatters-990	4	36	of	of	ADP
brainmatters-990	4	37	minnesota	minnesota	PROPN
brainmatters-990	4	38	.	.	PUNCT
brainmatters-990	5	1	using	use	VERB
brainmatters-990	5	2	high	high	ADJ
brainmatters-990	5	3	-	-	PUNCT
brainmatters-990	5	4	resolution	resolution	NOUN
brainmatters-990	5	5	resting	rest	VERB
brainmatters-990	5	6	-	-	PUNCT
brainmatters-990	5	7	state	state	NOUN
brainmatters-990	5	8	functional	functional	ADJ
brainmatters-990	5	9	mri	mri	NOUN
brainmatters-990	5	10	(	(	PUNCT
brainmatters-990	5	11	rs	rs	NOUN
brainmatters-990	5	12	-	-	PUNCT
brainmatters-990	5	13	fmri	fmri	ADJ
brainmatters-990	5	14	)	)	PUNCT
brainmatters-990	5	15	technology	technology	NOUN
brainmatters-990	5	16	,	,	PUNCT
brainmatters-990	5	17	researchers	researcher	NOUN
brainmatters-990	5	18	could	could	AUX
brainmatters-990	5	19	support	support	VERB
brainmatters-990	5	20	normal	normal	ADJ
brainmatters-990	5	21	neural	neural	ADJ
brainmatters-990	5	22	connections	connection	NOUN
brainmatters-990	5	23	using	use	VERB
brainmatters-990	5	24	liver	liver	NOUN
brainmatters-990	5	25	enzymes	enzyme	NOUN
brainmatters-990	5	26	.	.	PUNCT
brainmatters-990	6	1	this	this	DET
brainmatters-990	6	2	advanced	advanced	ADJ
brainmatters-990	6	3	approach	approach	NOUN
brainmatters-990	6	4	also	also	ADV
brainmatters-990	6	5	helps	help	VERB
brainmatters-990	6	6	monitor	monitor	VERB
brainmatters-990	6	7	brain	brain	NOUN
brainmatters-990	6	8	connectivity	connectivity	NOUN
brainmatters-990	6	9	in	in	ADP
brainmatters-990	6	10	other	other	ADJ
brainmatters-990	6	11	lysosomal	lysosomal	ADJ
brainmatters-990	6	12	disorders	disorder	NOUN
brainmatters-990	6	13	affecting	affect	VERB
brainmatters-990	6	14	brain	brain	NOUN
brainmatters-990	6	15	function	function	NOUN
brainmatters-990	6	16	(	(	PUNCT
brainmatters-990	6	17	university	university	NOUN
brainmatters-990	6	18	of	of	ADP
brainmatters-990	6	19	minnesota	minnesota	PROPN
brainmatters-990	6	20	,	,	PUNCT
brainmatters-990	6	21	2023	2023	NUM
brainmatters-990	6	22	)	)	PUNCT
brainmatters-990	6	23	.	.	PUNCT
brainmatters-990	7	1	lysosomal	lysosomal	ADJ
brainmatters-990	7	2	storage	storage	NOUN
brainmatters-990	7	3	diseases	disease	NOUN
brainmatters-990	7	4	lysosomes	lysosome	NOUN
brainmatters-990	7	5	,	,	PUNCT
brainmatters-990	7	6	integral	integral	ADJ
brainmatters-990	7	7	to	to	ADP
brainmatters-990	7	8	cellular	cellular	ADJ
brainmatters-990	7	9	function	function	NOUN
brainmatters-990	7	10	,	,	PUNCT
brainmatters-990	7	11	are	be	AUX
brainmatters-990	7	12	specialized	specialized	ADJ
brainmatters-990	7	13	membrane	membrane	NOUN
brainmatters-990	7	14	-	-	PUNCT
brainmatters-990	7	15	bound	bind	VERB
brainmatters-990	7	16	organelles	organelle	NOUN
brainmatters-990	7	17	that	that	PRON
brainmatters-990	7	18	house	house	VERB
brainmatters-990	7	19	digestive	digestive	ADJ
brainmatters-990	7	20	enzymes	enzyme	NOUN
brainmatters-990	7	21	.	.	PUNCT
brainmatters-990	8	1	these	these	DET
brainmatters-990	8	2	organelles	organelle	NOUN
brainmatters-990	8	3	consist	consist	VERB
brainmatters-990	8	4	of	of	ADP
brainmatters-990	8	5	luminal	luminal	ADJ
brainmatters-990	8	6	proteins	protein	NOUN
brainmatters-990	8	7	,	,	PUNCT
brainmatters-990	8	8	membraneintegral	membraneintegral	ADJ
brainmatters-990	8	9	proteins	protein	NOUN
brainmatters-990	8	10	,	,	PUNCT
brainmatters-990	8	11	and	and	CCONJ
brainmatters-990	8	12	associated	associated	ADJ
brainmatters-990	8	13	proteins	protein	NOUN
brainmatters-990	8	14	,	,	PUNCT
brainmatters-990	8	15	which	which	PRON
brainmatters-990	8	16	all	all	PRON
brainmatters-990	8	17	play	play	VERB
brainmatters-990	8	18	a	a	DET
brainmatters-990	8	19	crucial	crucial	ADJ
brainmatters-990	8	20	role	role	NOUN
brainmatters-990	8	21	in	in	ADP
brainmatters-990	8	22	cellular	cellular	ADJ
brainmatters-990	8	23	processes	process	NOUN
brainmatters-990	8	24	.	.	PUNCT
brainmatters-990	9	1	however	however	ADV
brainmatters-990	9	2	,	,	PUNCT
brainmatters-990	9	3	when	when	SCONJ
brainmatters-990	9	4	these	these	DET
brainmatters-990	9	5	components	component	NOUN
brainmatters-990	9	6	are	be	AUX
brainmatters-990	9	7	affected	affect	VERB
brainmatters-990	9	8	by	by	ADP
brainmatters-990	9	9	congenital	congenital	ADJ
brainmatters-990	9	10	metabolic	metabolic	ADJ
brainmatters-990	9	11	single	single	ADJ
brainmatters-990	9	12	-	-	PUNCT
brainmatters-990	9	13	gene	gene	NOUN
brainmatters-990	9	14	errors	error	NOUN
brainmatters-990	9	15	,	,	PUNCT
brainmatters-990	9	16	known	know	VERB
brainmatters-990	9	17	as	as	ADP
brainmatters-990	9	18	lysosomal	lysosomal	ADJ
brainmatters-990	9	19	storage	storage	NOUN
brainmatters-990	9	20	diseases	disease	NOUN
brainmatters-990	9	21	(	(	PUNCT
brainmatters-990	9	22	lsds	lsds	NOUN
brainmatters-990	9	23	)	)	PUNCT
brainmatters-990	9	24	,	,	PUNCT
brainmatters-990	9	25	the	the	DET
brainmatters-990	9	26	intricate	intricate	ADJ
brainmatters-990	9	27	balance	balance	NOUN
brainmatters-990	9	28	within	within	ADP
brainmatters-990	9	29	lysosomes	lysosome	NOUN
brainmatters-990	9	30	is	be	AUX
brainmatters-990	9	31	disrupted	disrupt	VERB
brainmatters-990	9	32	.	.	PUNCT
brainmatters-990	10	1	this	this	DET
brainmatters-990	10	2	disruption	disruption	NOUN
brainmatters-990	10	3	arises	arise	VERB
brainmatters-990	10	4	from	from	ADP
brainmatters-990	10	5	mutations	mutation	NOUN
brainmatters-990	10	6	in	in	ADP
brainmatters-990	10	7	lysosome	lysosome	NOUN
brainmatters-990	10	8	-	-	PUNCT
brainmatters-990	10	9	encoding	encode	VERB
brainmatters-990	10	10	genes	gene	NOUN
brainmatters-990	10	11	located	locate	VERB
brainmatters-990	10	12	on	on	ADP
brainmatters-990	10	13	a	a	DET
brainmatters-990	10	14	specific	specific	ADJ
brainmatters-990	10	15	chromosome	chromosome	NOUN
brainmatters-990	10	16	locus	locus	NOUN
brainmatters-990	10	17	,	,	PUNCT
brainmatters-990	10	18	leading	lead	VERB
brainmatters-990	10	19	to	to	ADP
brainmatters-990	10	20	the	the	DET
brainmatters-990	10	21	transcription	transcription	NOUN
brainmatters-990	10	22	of	of	ADP
brainmatters-990	10	23	defective	defective	ADJ
brainmatters-990	10	24	lysosomes	lysosome	NOUN
brainmatters-990	10	25	.	.	PUNCT
brainmatters-990	11	1	the	the	DET
brainmatters-990	11	2	consequences	consequence	NOUN
brainmatters-990	11	3	of	of	ADP
brainmatters-990	11	4	these	these	DET
brainmatters-990	11	5	disorders	disorder	NOUN
brainmatters-990	11	6	extend	extend	VERB
brainmatters-990	11	7	beyond	beyond	ADP
brainmatters-990	11	8	the	the	DET
brainmatters-990	11	9	molecular	molecular	ADJ
brainmatters-990	11	10	level	level	NOUN
brainmatters-990	11	11	,	,	PUNCT
brainmatters-990	11	12	manifesting	manifest	VERB
brainmatters-990	11	13	as	as	ADP
brainmatters-990	11	14	cell	cell	NOUN
brainmatters-990	11	15	swelling	swelling	NOUN
brainmatters-990	11	16	and	and	CCONJ
brainmatters-990	11	17	eventual	eventual	ADJ
brainmatters-990	11	18	organ	organ	NOUN
brainmatters-990	11	19	dysfunction	dysfunction	NOUN
brainmatters-990	11	20	at	at	ADP
brainmatters-990	11	21	the	the	DET
brainmatters-990	11	22	sites	site	NOUN
brainmatters-990	11	23	of	of	ADP
brainmatters-990	11	24	substrate	substrate	NOUN
brainmatters-990	11	25	accumulation	accumulation	NOUN
brainmatters-990	11	26	.	.	PUNCT
brainmatters-990	12	1	this	this	PRON
brainmatters-990	12	2	,	,	PUNCT
brainmatters-990	12	3	in	in	ADP
brainmatters-990	12	4	turn	turn	NOUN
brainmatters-990	12	5	,	,	PUNCT
brainmatters-990	12	6	significantly	significantly	ADV
brainmatters-990	12	7	contributes	contribute	VERB
brainmatters-990	12	8	to	to	ADP
brainmatters-990	12	9	morbidity	morbidity	NOUN
brainmatters-990	12	10	and	and	CCONJ
brainmatters-990	12	11	mortality	mortality	NOUN
brainmatters-990	12	12	.	.	PUNCT
brainmatters-990	13	1	notably	notably	ADV
brainmatters-990	13	2	,	,	PUNCT
brainmatters-990	13	3	the	the	DET
brainmatters-990	13	4	impact	impact	NOUN
brainmatters-990	13	5	is	be	AUX
brainmatters-990	13	6	more	more	ADV
brainmatters-990	13	7	pronounced	pronounce	VERB
brainmatters-990	13	8	in	in	ADP
brainmatters-990	13	9	infants	infant	NOUN
brainmatters-990	13	10	and	and	CCONJ
brainmatters-990	13	11	children	child	NOUN
brainmatters-990	13	12	,	,	PUNCT
brainmatters-990	13	13	as	as	SCONJ
brainmatters-990	13	14	their	their	PRON
brainmatters-990	13	15	developing	develop	VERB
brainmatters-990	13	16	brains	brain	NOUN
brainmatters-990	13	17	exhibit	exhibit	VERB
brainmatters-990	13	18	heightened	heighten	VERB
brainmatters-990	13	19	vulnerability	vulnerability	NOUN
brainmatters-990	13	20	to	to	ADP
brainmatters-990	13	21	dysfunction	dysfunction	NOUN
brainmatters-990	13	22	(	(	PUNCT
brainmatters-990	13	23	rajkumar	rajkumar	PROPN
brainmatters-990	13	24	,	,	PUNCT
brainmatters-990	13	25	dumpa	dumpa	NOUN
brainmatters-990	13	26	,	,	PUNCT
brainmatters-990	13	27	2023	2023	NUM
brainmatters-990	13	28	)	)	PUNCT
brainmatters-990	13	29	.	.	PUNCT
brainmatters-990	14	1	hurler	hurler	PROPN
brainmatters-990	14	2	syndrome	syndrome	PROPN
brainmatters-990	14	3	hurler	hurler	PROPN
brainmatters-990	14	4	syndrome	syndrome	NOUN
brainmatters-990	14	5	(	(	PUNCT
brainmatters-990	14	6	mps	mps	PROPN
brainmatters-990	14	7	i	i	PROPN
brainmatters-990	14	8	)	)	PUNCT
brainmatters-990	14	9	,	,	PUNCT
brainmatters-990	14	10	discovered	discover	VERB
brainmatters-990	14	11	by	by	ADP
brainmatters-990	14	12	german	german	ADJ
brainmatters-990	14	13	pediatrician	pediatrician	ADJ
brainmatters-990	14	14	gertrud	gertrud	NOUN
brainmatters-990	14	15	hurler	hurler	NOUN
brainmatters-990	14	16	in	in	ADP
brainmatters-990	14	17	1919	1919	NUM
brainmatters-990	14	18	,	,	PUNCT
brainmatters-990	14	19	stands	stand	VERB
brainmatters-990	14	20	among	among	ADP
brainmatters-990	14	21	the	the	DET
brainmatters-990	14	22	11	11	NUM
brainmatters-990	14	23	disorders	disorder	NOUN
brainmatters-990	14	24	of	of	ADP
brainmatters-990	14	25	mucopolysaccharidoses	mucopolysaccharidose	NOUN
brainmatters-990	14	26	(	(	PUNCT
brainmatters-990	14	27	mps	mps	PROPN
brainmatters-990	14	28	)	)	PUNCT
brainmatters-990	14	29	,	,	PUNCT
brainmatters-990	14	30	impacting	impact	VERB
brainmatters-990	14	31	roughly	roughly	ADV
brainmatters-990	14	32	1	1	NUM
brainmatters-990	14	33	in	in	ADP
brainmatters-990	14	34	100,000	100,000	NUM
brainmatters-990	14	35	births	birth	NOUN
brainmatters-990	14	36	.	.	PUNCT
brainmatters-990	15	1	this	this	DET
brainmatters-990	15	2	neurodegenerative	neurodegenerative	ADJ
brainmatters-990	15	3	condition	condition	NOUN
brainmatters-990	15	4	arises	arise	VERB
brainmatters-990	15	5	from	from	ADP
brainmatters-990	15	6	a	a	DET
brainmatters-990	15	7	mutation	mutation	NOUN
brainmatters-990	15	8	in	in	ADP
brainmatters-990	15	9	a	a	DET
brainmatters-990	15	10	gene	gene	NOUN
brainmatters-990	15	11	on	on	ADP
brainmatters-990	15	12	chromosome	chromosome	NOUN
brainmatters-990	15	13	4	4	NUM
brainmatters-990	15	14	,	,	PUNCT
brainmatters-990	15	15	tasked	task	VERB
brainmatters-990	15	16	with	with	ADP
brainmatters-990	15	17	encoding	encode	VERB
brainmatters-990	15	18	the	the	DET
brainmatters-990	15	19	lysosomal	lysosomal	ADJ
brainmatters-990	15	20	enzyme	enzyme	NOUN
brainmatters-990	15	21	α	α	NOUN
brainmatters-990	15	22	-	-	PUNCT
brainmatters-990	15	23	l	l	NOUN
brainmatters-990	15	24	-	-	NOUN
brainmatters-990	15	25	iduronidase	iduronidase	NOUN
brainmatters-990	15	26	(	(	PUNCT
brainmatters-990	15	27	idua	idua	PROPN
brainmatters-990	15	28	)	)	PUNCT
brainmatters-990	15	29	.	.	PUNCT
brainmatters-990	16	1	idua	idua	PROPN
brainmatters-990	16	2	plays	play	VERB
brainmatters-990	16	3	a	a	DET
brainmatters-990	16	4	pivotal	pivotal	ADJ
brainmatters-990	16	5	role	role	NOUN
brainmatters-990	16	6	in	in	ADP
brainmatters-990	16	7	breaking	break	VERB
brainmatters-990	16	8	down	down	ADP
brainmatters-990	16	9	glycosaminoglycans	glycosaminoglycan	NOUN
brainmatters-990	16	10	(	(	PUNCT
brainmatters-990	16	11	gag	gag	NOUN
brainmatters-990	16	12	)	)	PUNCT
brainmatters-990	16	13	,	,	PUNCT
brainmatters-990	16	14	such	such	ADJ
brainmatters-990	16	15	as	as	ADP
brainmatters-990	16	16	dermatan	dermatan	PROPN
brainmatters-990	16	17	sulfate	sulfate	NOUN
brainmatters-990	16	18	and	and	CCONJ
brainmatters-990	16	19	heparin	heparin	ADJ
brainmatters-990	16	20	sulfate	sulfate	NOUN
brainmatters-990	16	21	.	.	PUNCT
brainmatters-990	17	1	the	the	DET
brainmatters-990	17	2	overaccumulation	overaccumulation	NOUN
brainmatters-990	17	3	of	of	ADP
brainmatters-990	17	4	gag	gag	NOUN
brainmatters-990	17	5	leads	lead	VERB
brainmatters-990	17	6	to	to	ADP
brainmatters-990	17	7	the	the	DET
brainmatters-990	17	8	enlargement	enlargement	NOUN
brainmatters-990	17	9	and	and	CCONJ
brainmatters-990	17	10	thickening	thickening	NOUN
brainmatters-990	17	11	of	of	ADP
brainmatters-990	17	12	organs	organ	NOUN
brainmatters-990	17	13	like	like	ADP
brainmatters-990	17	14	the	the	DET
brainmatters-990	17	15	heart	heart	NOUN
brainmatters-990	17	16	,	,	PUNCT
brainmatters-990	17	17	spleen	spleen	NOUN
brainmatters-990	17	18	,	,	PUNCT
brainmatters-990	17	19	and	and	CCONJ
brainmatters-990	17	20	muscles	muscle	NOUN
brainmatters-990	17	21	,	,	PUNCT
brainmatters-990	17	22	while	while	SCONJ
brainmatters-990	17	23	also	also	ADV
brainmatters-990	17	24	impairing	impair	VERB
brainmatters-990	17	25	synapses	synapsis	NOUN
brainmatters-990	17	26	within	within	ADP
brainmatters-990	17	27	the	the	DET
brainmatters-990	17	28	central	central	ADJ
brainmatters-990	17	29	nervous	nervous	ADJ
brainmatters-990	17	30	system	system	NOUN
brainmatters-990	17	31	.	.	PUNCT
brainmatters-990	18	1	typically	typically	ADV
brainmatters-990	18	2	,	,	PUNCT
brainmatters-990	18	3	symptoms	symptom	NOUN
brainmatters-990	18	4	of	of	ADP
brainmatters-990	18	5	hurler	hurler	NOUN
brainmatters-990	18	6	syndrome	syndrome	NOUN
brainmatters-990	18	7	manifest	manifest	NOUN
brainmatters-990	18	8	in	in	ADP
brainmatters-990	18	9	the	the	DET
brainmatters-990	18	10	first	first	ADJ
brainmatters-990	18	11	year	year	NOUN
brainmatters-990	18	12	of	of	ADP
brainmatters-990	18	13	a	a	DET
brainmatters-990	18	14	child	child	NOUN
brainmatters-990	18	15	’s	’s	PART
brainmatters-990	18	16	life	life	NOUN
brainmatters-990	18	17	.	.	PUNCT
brainmatters-990	19	1	unfortunately	unfortunately	ADV
brainmatters-990	19	2	,	,	PUNCT
brainmatters-990	19	3	the	the	DET
brainmatters-990	19	4	average	average	ADJ
brainmatters-990	19	5	age	age	NOUN
brainmatters-990	19	6	of	of	ADP
brainmatters-990	19	7	mortality	mortality	NOUN
brainmatters-990	19	8	is	be	AUX
brainmatters-990	19	9	five	five	NUM
brainmatters-990	19	10	years	year	NOUN
brainmatters-990	19	11	,	,	PUNCT
brainmatters-990	19	12	with	with	ADP
brainmatters-990	19	13	the	the	DET
brainmatters-990	19	14	majority	majority	NOUN
brainmatters-990	19	15	of	of	ADP
brainmatters-990	19	16	patients	patient	NOUN
brainmatters-990	19	17	not	not	PART
brainmatters-990	19	18	surviving	survive	VERB
brainmatters-990	19	19	beyond	beyond	ADP
brainmatters-990	19	20	ten	ten	NUM
brainmatters-990	19	21	years	year	NOUN
brainmatters-990	19	22	.	.	PUNCT
brainmatters-990	20	1	indications	indication	NOUN
brainmatters-990	20	2	of	of	ADP
brainmatters-990	20	3	the	the	DET
brainmatters-990	20	4	disorder	disorder	NOUN
brainmatters-990	20	5	progressive	progressive	ADJ
brainmatters-990	20	6	developmental	developmental	ADJ
brainmatters-990	20	7	delay	delay	NOUN
brainmatters-990	20	8	,	,	PUNCT
brainmatters-990	20	9	respiratory	respiratory	ADJ
brainmatters-990	20	10	infections	infection	NOUN
brainmatters-990	20	11	,	,	PUNCT
brainmatters-990	20	12	and	and	CCONJ
brainmatters-990	20	13	cardiac	cardiac	ADJ
brainmatters-990	20	14	manifestations	manifestation	NOUN
brainmatters-990	20	15	.	.	PUNCT
brainmatters-990	21	1	diagnosis	diagnosis	NOUN
brainmatters-990	21	2	involves	involve	VERB
brainmatters-990	21	3	clinical	clinical	ADJ
brainmatters-990	21	4	examinations	examination	NOUN
brainmatters-990	21	5	of	of	ADP
brainmatters-990	21	6	urinary	urinary	ADJ
brainmatters-990	21	7	gag	gag	NOUN
brainmatters-990	21	8	levels	level	NOUN
brainmatters-990	21	9	and	and	CCONJ
brainmatters-990	21	10	dna	dna	NOUN
brainmatters-990	21	11	analysis	analysis	NOUN
brainmatters-990	21	12	.	.	PUNCT
brainmatters-990	22	1	to	to	PART
brainmatters-990	22	2	expand	expand	VERB
brainmatters-990	22	3	upon	upon	SCONJ
brainmatters-990	22	4	the	the	DET
brainmatters-990	22	5	latter	latter	ADJ
brainmatters-990	22	6	point	point	NOUN
brainmatters-990	22	7	,	,	PUNCT
brainmatters-990	22	8	gene	gene	NOUN
brainmatters-990	22	9	sequencing	sequence	VERB
brainmatters-990	22	10	aids	aid	NOUN
brainmatters-990	22	11	in	in	ADP
brainmatters-990	22	12	identifying	identify	VERB
brainmatters-990	22	13	inheritable	inheritable	ADJ
brainmatters-990	22	14	mutations	mutation	NOUN
brainmatters-990	22	15	and	and	CCONJ
brainmatters-990	22	16	facilitates	facilitate	VERB
brainmatters-990	22	17	improved	improve	VERB
brainmatters-990	22	18	family	family	NOUN
brainmatters-990	22	19	planning	planning	NOUN
brainmatters-990	22	20	.	.	PUNCT
brainmatters-990	23	1	in	in	ADP
brainmatters-990	23	2	contrast	contrast	NOUN
brainmatters-990	23	3	,	,	PUNCT
brainmatters-990	23	4	treatments	treatment	NOUN
brainmatters-990	23	5	primarily	primarily	ADV
brainmatters-990	23	6	target	target	VERB
brainmatters-990	23	7	symptoms	symptom	NOUN
brainmatters-990	23	8	of	of	ADP
brainmatters-990	23	9	the	the	DET
brainmatters-990	23	10	disorder	disorder	NOUN
brainmatters-990	23	11	rather	rather	ADV
brainmatters-990	23	12	than	than	ADP
brainmatters-990	23	13	their	their	PRON
brainmatters-990	23	14	underlying	underlie	VERB
brainmatters-990	23	15	abnormalities	abnormality	NOUN
brainmatters-990	23	16	.	.	PUNCT
brainmatters-990	24	1	options	option	NOUN
brainmatters-990	24	2	like	like	ADP
brainmatters-990	24	3	enzyme	enzyme	NOUN
brainmatters-990	24	4	replacement	replacement	NOUN
brainmatters-990	24	5	therapy	therapy	NOUN
brainmatters-990	24	6	(	(	PUNCT
brainmatters-990	24	7	ert	ert	PROPN
brainmatters-990	24	8	)	)	PUNCT
brainmatters-990	24	9	through	through	ADP
brainmatters-990	24	10	intravenous	intravenous	ADJ
brainmatters-990	24	11	injections	injection	NOUN
brainmatters-990	24	12	of	of	ADP
brainmatters-990	24	13	recombinant	recombinant	ADJ
brainmatters-990	24	14	idua	idua	ADJ
brainmatters-990	24	15	and	and	CCONJ
brainmatters-990	24	16	hematopoietic	hematopoietic	ADJ
brainmatters-990	24	17	stem	stem	NOUN
brainmatters-990	24	18	cell	cell	NOUN
brainmatters-990	24	19	transplants	transplant	NOUN
brainmatters-990	24	20	(	(	PUNCT
brainmatters-990	24	21	hsct	hsct	PROPN
brainmatters-990	24	22	)	)	PUNCT
brainmatters-990	24	23	offer	offer	VERB
brainmatters-990	24	24	some	some	DET
brainmatters-990	24	25	relief	relief	NOUN
brainmatters-990	24	26	.	.	PUNCT
brainmatters-990	25	1	hsct	hsct	PROPN
brainmatters-990	25	2	gradually	gradually	ADV
brainmatters-990	25	3	substitutes	substitute	VERB
brainmatters-990	25	4	donor	donor	NOUN
brainmatters-990	25	5	-	-	PUNCT
brainmatters-990	25	6	derived	derive	VERB
brainmatters-990	25	7	,	,	PUNCT
brainmatters-990	25	8	enzymecompetent	enzymecompetent	NOUN
brainmatters-990	25	9	cells	cell	NOUN
brainmatters-990	25	10	for	for	ADP
brainmatters-990	25	11	hematopoietic	hematopoietic	ADJ
brainmatters-990	25	12	cells	cell	NOUN
brainmatters-990	25	13	lacking	lack	VERB
brainmatters-990	25	14	enzymes	enzyme	NOUN
brainmatters-990	25	15	(	(	PUNCT
brainmatters-990	25	16	sakuru	sakuru	NOUN
brainmatters-990	25	17	,	,	PUNCT
brainmatters-990	25	18	bollu	bollu	NOUN
brainmatters-990	25	19	,	,	PUNCT
brainmatters-990	25	20	2023	2023	NUM
brainmatters-990	25	21	)	)	PUNCT
brainmatters-990	25	22	.	.	PUNCT
brainmatters-990	26	1	however	however	ADV
brainmatters-990	26	2	,	,	PUNCT
brainmatters-990	26	3	it	it	PRON
brainmatters-990	26	4	is	be	AUX
brainmatters-990	26	5	important	important	ADJ
brainmatters-990	26	6	to	to	PART
brainmatters-990	26	7	note	note	VERB
brainmatters-990	26	8	that	that	SCONJ
brainmatters-990	26	9	ert	ert	NOUN
brainmatters-990	26	10	can	can	AUX
brainmatters-990	26	11	not	not	PART
brainmatters-990	26	12	cross	cross	VERB
brainmatters-990	26	13	the	the	DET
brainmatters-990	26	14	blood	blood	NOUN
brainmatters-990	26	15	-	-	PUNCT
brainmatters-990	26	16	brain	brain	NOUN
brainmatters-990	26	17	barrier	barrier	NOUN
brainmatters-990	26	18	,	,	PUNCT
brainmatters-990	26	19	limiting	limit	VERB
brainmatters-990	26	20	its	its	PRON
brainmatters-990	26	21	efficacy	efficacy	NOUN
brainmatters-990	26	22	in	in	ADP
brainmatters-990	26	23	curing	cure	VERB
brainmatters-990	26	24	the	the	DET
brainmatters-990	26	25	central	central	ADJ
brainmatters-990	26	26	nervous	nervous	ADJ
brainmatters-990	26	27	system	system	NOUN
brainmatters-990	26	28	,	,	PUNCT
brainmatters-990	26	29	a	a	DET
brainmatters-990	26	30	critical	critical	ADJ
brainmatters-990	26	31	concern	concern	NOUN
brainmatters-990	26	32	for	for	ADP
brainmatters-990	26	33	severe	severe	ADJ
brainmatters-990	26	34	mps	mp	NOUN
brainmatters-990	26	35	i	i	PRON
brainmatters-990	26	36	patients	patient	VERB
brainmatters-990	26	37	(	(	PUNCT
brainmatters-990	26	38	concolino	concolino	VERB
brainmatters-990	26	39	et	et	PROPN
brainmatters-990	26	40	al	al	PROPN
brainmatters-990	26	41	.	.	PROPN
brainmatters-990	26	42	,	,	PUNCT
brainmatters-990	26	43	2018	2018	NUM
brainmatters-990	26	44	)	)	PUNCT
brainmatters-990	26	45	.	.	PUNCT
brainmatters-990	27	1	additional	additional	ADJ
brainmatters-990	27	2	interventions	intervention	NOUN
brainmatters-990	27	3	may	may	AUX
brainmatters-990	27	4	include	include	VERB
brainmatters-990	27	5	surgical	surgical	ADJ
brainmatters-990	27	6	procedures	procedure	NOUN
brainmatters-990	27	7	such	such	ADJ
brainmatters-990	27	8	as	as	ADP
brainmatters-990	27	9	cardiac	cardiac	ADJ
brainmatters-990	27	10	valve	valve	NOUN
brainmatters-990	27	11	replacement	replacement	NOUN
brainmatters-990	27	12	and	and	CCONJ
brainmatters-990	27	13	spinal	spinal	ADJ
brainmatters-990	27	14	decompression	decompression	NOUN
brainmatters-990	27	15	to	to	PART
brainmatters-990	27	16	address	address	VERB
brainmatters-990	27	17	specific	specific	ADJ
brainmatters-990	27	18	symptoms	symptom	NOUN
brainmatters-990	27	19	(	(	PUNCT
brainmatters-990	27	20	sakuru	sakuru	NOUN
brainmatters-990	27	21	,	,	PUNCT
brainmatters-990	27	22	bollu	bollu	NOUN
brainmatters-990	27	23	,	,	PUNCT
brainmatters-990	27	24	2023	2023	NUM
brainmatters-990	27	25	)	)	PUNCT
brainmatters-990	27	26	.	.	PUNCT
brainmatters-990	28	1	therefore	therefore	ADV
brainmatters-990	28	2	,	,	PUNCT
brainmatters-990	28	3	it	it	PRON
brainmatters-990	28	4	is	be	AUX
brainmatters-990	28	5	imperative	imperative	ADJ
brainmatters-990	28	6	to	to	PART
brainmatters-990	28	7	seek	seek	VERB
brainmatters-990	28	8	alternative	alternative	ADJ
brainmatters-990	28	9	therapies	therapy	NOUN
brainmatters-990	28	10	that	that	PRON
brainmatters-990	28	11	are	be	AUX
brainmatters-990	28	12	less	less	ADV
brainmatters-990	28	13	risky	risky	ADJ
brainmatters-990	28	14	.	.	PUNCT
brainmatters-990	29	1	gene	gene	NOUN
brainmatters-990	29	2	therapy	therapy	NOUN
brainmatters-990	29	3	gene	gene	NOUN
brainmatters-990	29	4	therapy	therapy	NOUN
brainmatters-990	29	5	is	be	AUX
brainmatters-990	29	6	a	a	DET
brainmatters-990	29	7	dynamic	dynamic	ADJ
brainmatters-990	29	8	field	field	NOUN
brainmatters-990	29	9	in	in	ADP
brainmatters-990	29	10	biomedical	biomedical	ADJ
brainmatters-990	29	11	science	science	NOUN
brainmatters-990	29	12	,	,	PUNCT
brainmatters-990	29	13	orchestrating	orchestrate	VERB
brainmatters-990	29	14	the	the	DET
brainmatters-990	29	15	modulation	modulation	NOUN
brainmatters-990	29	16	of	of	ADP
brainmatters-990	29	17	gene	gene	NOUN
brainmatters-990	29	18	expression	expression	NOUN
brainmatters-990	29	19	to	to	PART
brainmatters-990	29	20	reshape	reshape	VERB
brainmatters-990	29	21	the	the	DET
brainmatters-990	29	22	biological	biological	ADJ
brainmatters-990	29	23	function	function	NOUN
brainmatters-990	29	24	of	of	ADP
brainmatters-990	29	25	living	living	NOUN
brainmatters-990	29	26	cells	cell	NOUN
brainmatters-990	29	27	.	.	PUNCT
brainmatters-990	30	1	this	this	DET
brainmatters-990	30	2	versatile	versatile	ADJ
brainmatters-990	30	3	approach	approach	NOUN
brainmatters-990	30	4	offers	offer	VERB
brainmatters-990	30	5	the	the	DET
brainmatters-990	30	6	capacity	capacity	NOUN
brainmatters-990	30	7	to	to	PART
brainmatters-990	30	8	replace	replace	VERB
brainmatters-990	30	9	defective	defective	ADJ
brainmatters-990	30	10	genes	gene	NOUN
brainmatters-990	30	11	with	with	ADP
brainmatters-990	30	12	healthy	healthy	ADJ
brainmatters-990	30	13	counterparts	counterpart	NOUN
brainmatters-990	30	14	,	,	PUNCT
brainmatters-990	30	15	inactivate	inactivate	VERB
brainmatters-990	30	16	disease	disease	NOUN
brainmatters-990	30	17	-	-	PUNCT
brainmatters-990	30	18	causing	cause	VERB
brainmatters-990	30	19	genes	gene	NOUN
brainmatters-990	30	20	,	,	PUNCT
brainmatters-990	30	21	or	or	CCONJ
brainmatters-990	30	22	introduce	introduce	VERB
brainmatters-990	30	23	modified	modified	ADJ
brainmatters-990	30	24	genes	gene	NOUN
brainmatters-990	30	25	to	to	PART
brainmatters-990	30	26	treat	treat	VERB
brainmatters-990	30	27	specific	specific	ADJ
brainmatters-990	30	28	diseases	disease	NOUN
brainmatters-990	30	29	.	.	PUNCT
brainmatters-990	31	1	therefore	therefore	ADV
brainmatters-990	31	2	,	,	PUNCT
brainmatters-990	31	3	it	it	PRON
brainmatters-990	31	4	presents	present	VERB
brainmatters-990	31	5	effective	effective	ADJ
brainmatters-990	31	6	applications	application	NOUN
brainmatters-990	31	7	in	in	ADP
brainmatters-990	31	8	conditions	condition	NOUN
brainmatters-990	31	9	like	like	ADP
brainmatters-990	31	10	cancer	cancer	NOUN
brainmatters-990	31	11	,	,	PUNCT
brainmatters-990	31	12	cystic	cystic	ADJ
brainmatters-990	31	13	fibrosis	fibrosis	NOUN
brainmatters-990	31	14	,	,	PUNCT
brainmatters-990	31	15	and	and	CCONJ
brainmatters-990	31	16	diabetes	diabetes	NOUN
brainmatters-990	31	17	.	.	PUNCT
brainmatters-990	32	1	the	the	DET
brainmatters-990	32	2	procedural	procedural	ADJ
brainmatters-990	32	3	aspect	aspect	NOUN
brainmatters-990	32	4	involves	involve	VERB
brainmatters-990	32	5	the	the	DET
brainmatters-990	32	6	introduction	introduction	NOUN
brainmatters-990	32	7	of	of	ADP
brainmatters-990	32	8	genes	gene	NOUN
brainmatters-990	32	9	into	into	ADP
brainmatters-990	32	10	the	the	DET
brainmatters-990	32	11	body	body	NOUN
brainmatters-990	32	12	via	via	ADP
brainmatters-990	32	13	carriers	carrier	NOUN
brainmatters-990	32	14	known	know	VERB
brainmatters-990	32	15	as	as	ADP
brainmatters-990	32	16	vectors	vector	NOUN
brainmatters-990	32	17	,	,	PUNCT
brainmatters-990	32	18	with	with	ADP
brainmatters-990	32	19	viruses	virus	NOUN
brainmatters-990	32	20	being	be	AUX
brainmatters-990	32	21	the	the	DET
brainmatters-990	32	22	primary	primary	ADJ
brainmatters-990	32	23	vehicles	vehicle	NOUN
brainmatters-990	32	24	due	due	ADP
brainmatters-990	32	25	to	to	ADP
brainmatters-990	32	26	their	their	PRON
brainmatters-990	32	27	ability	ability	NOUN
brainmatters-990	32	28	to	to	PART
brainmatters-990	32	29	recognize	recognize	VERB
brainmatters-990	32	30	target	target	NOUN
brainmatters-990	32	31	cells	cell	NOUN
brainmatters-990	32	32	and	and	CCONJ
brainmatters-990	32	33	facilitate	facilitate	VERB
brainmatters-990	32	34	genetic	genetic	ADJ
brainmatters-990	32	35	transfer	transfer	NOUN
brainmatters-990	32	36	.	.	PUNCT
brainmatters-990	33	1	figure	figure	NOUN
brainmatters-990	33	2	1	1	NUM
brainmatters-990	33	3	portrays	portray	VERB
brainmatters-990	33	4	a	a	DET
brainmatters-990	33	5	simplified	simplified	ADJ
brainmatters-990	33	6	diagram	diagram	NOUN
brainmatters-990	33	7	of	of	ADP
brainmatters-990	33	8	the	the	DET
brainmatters-990	33	9	method	method	NOUN
brainmatters-990	33	10	.	.	PUNCT
brainmatters-990	34	1	however	however	ADV
brainmatters-990	34	2	,	,	PUNCT
brainmatters-990	34	3	amidst	amidst	ADP
brainmatters-990	34	4	the	the	DET
brainmatters-990	34	5	promises	promise	NOUN
brainmatters-990	34	6	of	of	ADP
brainmatters-990	34	7	gene	gene	NOUN
brainmatters-990	34	8	therapy	therapy	NOUN
brainmatters-990	34	9	lie	lie	VERB
brainmatters-990	34	10	inherent	inherent	ADJ
brainmatters-990	34	11	risks	risk	NOUN
brainmatters-990	34	12	.	.	PUNCT
brainmatters-990	35	1	as	as	SCONJ
brainmatters-990	35	2	the	the	DET
brainmatters-990	35	3	body	body	NOUN
brainmatters-990	35	4	encounters	encounter	VERB
brainmatters-990	35	5	the	the	DET
brainmatters-990	35	6	introduced	introduce	VERB
brainmatters-990	35	7	viral	viral	ADJ
brainmatters-990	35	8	vectors	vector	NOUN
brainmatters-990	35	9	,	,	PUNCT
brainmatters-990	35	10	an	an	DET
brainmatters-990	35	11	undesired	undesired	ADJ
brainmatters-990	35	12	immune	immune	ADJ
brainmatters-990	35	13	response	response	NOUN
brainmatters-990	35	14	may	may	AUX
brainmatters-990	35	15	ensue	ensue	VERB
brainmatters-990	35	16	,	,	PUNCT
brainmatters-990	35	17	potentially	potentially	ADV
brainmatters-990	35	18	resulting	result	VERB
brainmatters-990	35	19	in	in	ADP
brainmatters-990	35	20	inflammation	inflammation	NOUN
brainmatters-990	35	21	and	and	CCONJ
brainmatters-990	35	22	,	,	PUNCT
brainmatters-990	35	23	in	in	ADP
brainmatters-990	35	24	severe	severe	ADJ
brainmatters-990	35	25	cases	case	NOUN
brainmatters-990	35	26	,	,	PUNCT
brainmatters-990	35	27	organ	organ	NOUN
brainmatters-990	35	28	failure	failure	NOUN
brainmatters-990	35	29	.	.	PUNCT
brainmatters-990	36	1	precision	precision	NOUN
brainmatters-990	36	2	errors	error	NOUN
brainmatters-990	36	3	with	with	ADP
brainmatters-990	36	4	the	the	DET
brainmatters-990	36	5	vectors	vector	NOUN
brainmatters-990	36	6	may	may	AUX
brainmatters-990	36	7	lead	lead	VERB
brainmatters-990	36	8	to	to	ADP
brainmatters-990	36	9	unintended	unintended	ADJ
brainmatters-990	36	10	targeting	targeting	NOUN
brainmatters-990	36	11	,	,	PUNCT
brainmatters-990	36	12	affecting	affect	VERB
brainmatters-990	36	13	healthy	healthy	ADJ
brainmatters-990	36	14	cells	cell	NOUN
brainmatters-990	36	15	,	,	PUNCT
brainmatters-990	36	16	or	or	CCONJ
brainmatters-990	36	17	causing	cause	VERB
brainmatters-990	36	18	infections	infection	NOUN
brainmatters-990	36	19	.	.	PUNCT
brainmatters-990	37	1	missteps	misstep	NOUN
brainmatters-990	37	2	in	in	ADP
brainmatters-990	37	3	gene	gene	NOUN
brainmatters-990	37	4	insertions	insertion	NOUN
brainmatters-990	37	5	hold	hold	VERB
brainmatters-990	37	6	the	the	DET
brainmatters-990	37	7	potential	potential	NOUN
brainmatters-990	37	8	for	for	ADP
brainmatters-990	37	9	tumor	tumor	NOUN
brainmatters-990	37	10	formation	formation	NOUN
brainmatters-990	37	11	(	(	PUNCT
brainmatters-990	37	12	mayo	mayo	NOUN
brainmatters-990	37	13	clinic	clinic	NOUN
brainmatters-990	37	14	,	,	PUNCT
brainmatters-990	37	15	2017	2017	NUM
brainmatters-990	37	16	)	)	PUNCT
brainmatters-990	37	17	.	.	PUNCT
brainmatters-990	38	1	the	the	DET
brainmatters-990	38	2	highly	highly	ADV
brainmatters-990	38	3	expressed	express	VERB
brainmatters-990	38	4	endogenous	endogenous	ADJ
brainmatters-990	38	5	albumin	albumin	ADJ
brainmatters-990	38	6	promoter	promoter	NOUN
brainmatters-990	38	7	assumes	assume	VERB
brainmatters-990	38	8	a	a	DET
brainmatters-990	38	9	pivotal	pivotal	ADJ
brainmatters-990	38	10	role	role	NOUN
brainmatters-990	38	11	in	in	ADP
brainmatters-990	38	12	governing	govern	VERB
brainmatters-990	38	13	the	the	DET
brainmatters-990	38	14	transgene	transgene	NOUN
brainmatters-990	38	15	’s	’s	PART
brainmatters-990	38	16	expression	expression	NOUN
brainmatters-990	38	17	,	,	PUNCT
brainmatters-990	38	18	with	with	ADP
brainmatters-990	38	19	its	its	PRON
brainmatters-990	38	20	benefits	benefit	NOUN
brainmatters-990	38	21	harnessed	harness	VERB
brainmatters-990	38	22	through	through	ADP
brainmatters-990	38	23	a	a	DET
brainmatters-990	38	24	mechanism	mechanism	NOUN
brainmatters-990	38	25	known	know	VERB
brainmatters-990	38	26	as	as	ADP
brainmatters-990	38	27	cross	cross	NOUN
brainmatters-990	38	28	-	-	NOUN
brainmatters-990	38	29	correction	correction	NOUN
brainmatters-990	38	30	.	.	PUNCT
brainmatters-990	39	1	in	in	ADP
brainmatters-990	39	2	this	this	DET
brainmatters-990	39	3	process	process	NOUN
brainmatters-990	39	4	,	,	PUNCT
brainmatters-990	39	5	a	a	DET
brainmatters-990	39	6	lysosomal	lysosomal	ADJ
brainmatters-990	39	7	enzyme	enzyme	NOUN
brainmatters-990	39	8	produced	produce	VERB
brainmatters-990	39	9	by	by	ADP
brainmatters-990	39	10	one	one	NUM
brainmatters-990	39	11	cell	cell	NOUN
brainmatters-990	39	12	is	be	AUX
brainmatters-990	39	13	released	release	VERB
brainmatters-990	39	14	and	and	CCONJ
brainmatters-990	39	15	subsequently	subsequently	ADV
brainmatters-990	39	16	internalized	internalize	VERB
brainmatters-990	39	17	by	by	ADP
brainmatters-990	39	18	another	another	DET
brainmatters-990	39	19	cell	cell	NOUN
brainmatters-990	39	20	.	.	PUNCT
brainmatters-990	40	1	this	this	PRON
brainmatters-990	40	2	facilitates	facilitate	VERB
brainmatters-990	40	3	the	the	DET
brainmatters-990	40	4	degradation	degradation	NOUN
brainmatters-990	40	5	of	of	ADP
brainmatters-990	40	6	stored	store	VERB
brainmatters-990	40	7	materials	material	NOUN
brainmatters-990	40	8	,	,	PUNCT
brainmatters-990	40	9	culminating	culminate	VERB
brainmatters-990	40	10	in	in	ADP
brainmatters-990	40	11	metabolic	metabolic	NOUN
brainmatters-990	40	12	correction	correction	NOUN
brainmatters-990	40	13	.	.	PUNCT
brainmatters-990	41	1	to	to	PART
brainmatters-990	41	2	prevent	prevent	VERB
brainmatters-990	41	3	transgene	transgene	ADJ
brainmatters-990	41	4	expression	expression	NOUN
brainmatters-990	41	5	in	in	ADP
brainmatters-990	41	6	the	the	DET
brainmatters-990	41	7	central	central	ADJ
brainmatters-990	41	8	nervous	nervous	ADJ
brainmatters-990	41	9	system	system	NOUN
brainmatters-990	41	10	,	,	PUNCT
brainmatters-990	41	11	the	the	DET
brainmatters-990	41	12	researchers	researcher	NOUN
brainmatters-990	41	13	strategically	strategically	ADV
brainmatters-990	41	14	employed	employ	VERB
brainmatters-990	41	15	liver	liver	NOUN
brainmatters-990	41	16	-	-	PUNCT
brainmatters-990	41	17	specific	specific	ADJ
brainmatters-990	41	18	human	human	ADJ
brainmatters-990	41	19	idua	idua	NOUN
brainmatters-990	41	20	.	.	PUNCT
brainmatters-990	42	1	the	the	DET
brainmatters-990	42	2	technique	technique	NOUN
brainmatters-990	42	3	showed	show	VERB
brainmatters-990	42	4	positive	positive	ADJ
brainmatters-990	42	5	results	result	NOUN
brainmatters-990	42	6	,	,	PUNCT
brainmatters-990	42	7	as	as	SCONJ
brainmatters-990	42	8	evidenced	evidence	VERB
brainmatters-990	42	9	by	by	ADP
brainmatters-990	42	10	elevated	elevated	ADJ
brainmatters-990	42	11	idua	idua	ADJ
brainmatters-990	42	12	activity	activity	NOUN
brainmatters-990	42	13	and	and	CCONJ
brainmatters-990	42	14	reduced	reduce	VERB
brainmatters-990	42	15	gag	gag	NOUN
brainmatters-990	42	16	levels	level	NOUN
brainmatters-990	42	17	in	in	ADP
brainmatters-990	42	18	both	both	CCONJ
brainmatters-990	42	19	the	the	DET
brainmatters-990	42	20	liver	liver	NOUN
brainmatters-990	42	21	and	and	CCONJ
brainmatters-990	42	22	brain	brain	NOUN
brainmatters-990	42	23	.	.	PUNCT
brainmatters-990	43	1	the	the	DET
brainmatters-990	43	2	findings	finding	NOUN
brainmatters-990	43	3	suggest	suggest	VERB
brainmatters-990	43	4	that	that	SCONJ
brainmatters-990	43	5	maintaining	maintain	VERB
brainmatters-990	43	6	a	a	DET
brainmatters-990	43	7	consistently	consistently	ADV
brainmatters-990	43	8	elevated	elevated	ADJ
brainmatters-990	43	9	level	level	NOUN
brainmatters-990	43	10	of	of	ADP
brainmatters-990	43	11	idua	idua	NOUN
brainmatters-990	43	12	in	in	ADP
brainmatters-990	43	13	the	the	DET
brainmatters-990	43	14	bloodstream	bloodstream	NOUN
brainmatters-990	43	15	leads	lead	VERB
brainmatters-990	43	16	to	to	ADP
brainmatters-990	43	17	a	a	DET
brainmatters-990	43	18	modest	modest	ADJ
brainmatters-990	43	19	yet	yet	CCONJ
brainmatters-990	43	20	sufficient	sufficient	ADJ
brainmatters-990	43	21	entry	entry	NOUN
brainmatters-990	43	22	of	of	ADP
brainmatters-990	43	23	idua	idua	PROPN
brainmatters-990	43	24	into	into	ADP
brainmatters-990	43	25	the	the	DET
brainmatters-990	43	26	brain	brain	NOUN
brainmatters-990	43	27	.	.	PUNCT
brainmatters-990	44	1	notably	notably	ADV
brainmatters-990	44	2	,	,	PUNCT
brainmatters-990	44	3	a	a	DET
brainmatters-990	44	4	particular	particular	ADJ
brainmatters-990	44	5	grna,5′gtatctttgatgacaataatgggggat-3′	grna,5′gtatctttgatgacaataatgggggat-3′	PROPN
brainmatters-990	44	6	,	,	PUNCT
brainmatters-990	44	7	demonstrated	demonstrate	VERB
brainmatters-990	44	8	the	the	DET
brainmatters-990	44	9	highest	high	ADJ
brainmatters-990	44	10	efficiency	efficiency	NOUN
brainmatters-990	44	11	in	in	ADP
brainmatters-990	44	12	driving	drive	VERB
brainmatters-990	44	13	therapeutic	therapeutic	ADJ
brainmatters-990	44	14	effects	effect	NOUN
brainmatters-990	44	15	.	.	PUNCT
brainmatters-990	45	1	the	the	DET
brainmatters-990	45	2	inherent	inherent	ADJ
brainmatters-990	45	3	advantage	advantage	NOUN
brainmatters-990	45	4	of	of	ADP
brainmatters-990	45	5	ps	ps	NOUN
brainmatters-990	45	6	gene	gene	NOUN
brainmatters-990	45	7	editing	edit	VERB
brainmatters-990	45	8	lies	lie	NOUN
brainmatters-990	45	9	in	in	ADP
brainmatters-990	45	10	its	its	PRON
brainmatters-990	45	11	potential	potential	NOUN
brainmatters-990	45	12	to	to	PART
brainmatters-990	45	13	yield	yield	VERB
brainmatters-990	45	14	elevated	elevated	ADJ
brainmatters-990	45	15	enzyme	enzyme	NOUN
brainmatters-990	45	16	levels	level	NOUN
brainmatters-990	45	17	with	with	ADP
brainmatters-990	45	18	a	a	DET
brainmatters-990	45	19	single	single	ADJ
brainmatters-990	45	20	administration	administration	NOUN
brainmatters-990	45	21	.	.	PUNCT
brainmatters-990	46	1	this	this	DET
brainmatters-990	46	2	efficiency	efficiency	NOUN
brainmatters-990	46	3	arises	arise	VERB
brainmatters-990	46	4	from	from	ADP
brainmatters-990	46	5	the	the	DET
brainmatters-990	46	6	increased	increase	VERB
brainmatters-990	46	7	likelihood	likelihood	NOUN
brainmatters-990	46	8	of	of	ADP
brainmatters-990	46	9	successfully	successfully	ADV
brainmatters-990	46	10	edited	edit	VERB
brainmatters-990	46	11	hepatocytes	hepatocyte	NOUN
brainmatters-990	46	12	.	.	PUNCT
brainmatters-990	47	1	consequently	consequently	ADV
brainmatters-990	47	2	,	,	PUNCT
brainmatters-990	47	3	the	the	DET
brainmatters-990	47	4	application	application	NOUN
brainmatters-990	47	5	of	of	ADP
brainmatters-990	47	6	ps	ps	PROPN
brainmatters-990	47	7	gene	gene	NOUN
brainmatters-990	47	8	editing	editing	NOUN
brainmatters-990	47	9	opens	open	VERB
brainmatters-990	47	10	avenues	avenue	NOUN
brainmatters-990	47	11	for	for	ADP
brainmatters-990	47	12	administering	administer	VERB
brainmatters-990	47	13	reduced	reduce	VERB
brainmatters-990	47	14	doses	dose	NOUN
brainmatters-990	47	15	of	of	ADP
brainmatters-990	47	16	the	the	DET
brainmatters-990	47	17	adeno	adeno	NOUN
brainmatters-990	47	18	-	-	PUNCT
brainmatters-990	47	19	associated	associate	VERB
brainmatters-990	47	20	virus	virus	NOUN
brainmatters-990	47	21	(	(	PUNCT
brainmatters-990	47	22	aav	aav	NOUN
brainmatters-990	47	23	)	)	PUNCT
brainmatters-990	47	24	vector	vector	NOUN
brainmatters-990	47	25	for	for	ADP
brainmatters-990	47	26	the	the	DET
brainmatters-990	47	27	treatment	treatment	NOUN
brainmatters-990	47	28	of	of	ADP
brainmatters-990	47	29	lsds	lsds	NOUN
brainmatters-990	47	30	.	.	PUNCT
brainmatters-990	48	1	this	this	PRON
brainmatters-990	48	2	not	not	PART
brainmatters-990	48	3	only	only	ADV
brainmatters-990	48	4	mitigates	mitigate	VERB
brainmatters-990	48	5	toxicity	toxicity	NOUN
brainmatters-990	48	6	but	but	CCONJ
brainmatters-990	48	7	also	also	ADV
brainmatters-990	48	8	streamlines	streamline	VERB
brainmatters-990	48	9	vector	vector	NOUN
brainmatters-990	48	10	production	production	NOUN
brainmatters-990	48	11	,	,	PUNCT
brainmatters-990	48	12	thereby	thereby	ADV
brainmatters-990	48	13	reducing	reduce	VERB
brainmatters-990	48	14	overall	overall	ADJ
brainmatters-990	48	15	costs	cost	NOUN
brainmatters-990	48	16	.	.	PUNCT
brainmatters-990	49	1	the	the	DET
brainmatters-990	49	2	significance	significance	NOUN
brainmatters-990	49	3	of	of	ADP
brainmatters-990	49	4	this	this	DET
brainmatters-990	49	5	approach	approach	NOUN
brainmatters-990	49	6	becomes	becomes	AUX
brainmatters-990	49	7	pronounced	pronounce	VERB
brainmatters-990	49	8	in	in	ADP
brainmatters-990	49	9	the	the	DET
brainmatters-990	49	10	context	context	NOUN
brainmatters-990	49	11	of	of	ADP
brainmatters-990	49	12	lsd	lsd	NOUN
brainmatters-990	49	13	patients	patient	NOUN
brainmatters-990	49	14	,	,	PUNCT
brainmatters-990	49	15	particularly	particularly	ADV
brainmatters-990	49	16	children	child	NOUN
brainmatters-990	49	17	,	,	PUNCT
brainmatters-990	49	18	where	where	SCONJ
brainmatters-990	49	19	uninterrupted	uninterrupted	ADJ
brainmatters-990	49	20	cell	cell	NOUN
brainmatters-990	49	21	division	division	NOUN
brainmatters-990	49	22	is	be	AUX
brainmatters-990	49	23	essential	essential	ADJ
brainmatters-990	49	24	for	for	ADP
brainmatters-990	49	25	normal	normal	ADJ
brainmatters-990	49	26	growth	growth	NOUN
brainmatters-990	49	27	.	.	PUNCT
brainmatters-990	50	1	traditional	traditional	ADJ
brainmatters-990	50	2	aav	aav	NOUN
brainmatters-990	50	3	gene	gene	NOUN
brainmatters-990	50	4	therapy	therapy	NOUN
brainmatters-990	50	5	encounters	encounter	VERB
brainmatters-990	50	6	a	a	DET
brainmatters-990	50	7	significant	significant	ADJ
brainmatters-990	50	8	hurdle	hurdle	NOUN
brainmatters-990	50	9	in	in	ADP
brainmatters-990	50	10	the	the	DET
brainmatters-990	50	11	form	form	NOUN
brainmatters-990	50	12	of	of	ADP
brainmatters-990	50	13	vector	vector	NOUN
brainmatters-990	50	14	dilution	dilution	NOUN
brainmatters-990	50	15	as	as	SCONJ
brainmatters-990	50	16	children	child	NOUN
brainmatters-990	50	17	undergo	undergo	VERB
brainmatters-990	50	18	growth	growth	NOUN
brainmatters-990	50	19	and	and	CCONJ
brainmatters-990	50	20	maturation	maturation	NOUN
brainmatters-990	50	21	.	.	PUNCT
brainmatters-990	51	1	the	the	DET
brainmatters-990	51	2	primary	primary	ADJ
brainmatters-990	51	3	merit	merit	NOUN
brainmatters-990	51	4	of	of	ADP
brainmatters-990	51	5	ps	ps	PROPN
brainmatters-990	51	6	lies	lie	VERB
brainmatters-990	51	7	in	in	ADP
brainmatters-990	51	8	its	its	PRON
brainmatters-990	51	9	potential	potential	NOUN
brainmatters-990	51	10	to	to	PART
brainmatters-990	51	11	confer	confer	VERB
brainmatters-990	51	12	sustained	sustain	VERB
brainmatters-990	51	13	therapeutic	therapeutic	ADJ
brainmatters-990	51	14	benefits	benefit	NOUN
brainmatters-990	51	15	throughout	throughout	ADP
brainmatters-990	51	16	an	an	DET
brainmatters-990	51	17	individual	individual	NOUN
brainmatters-990	51	18	’s	’s	PART
brainmatters-990	51	19	life	life	NOUN
brainmatters-990	51	20	,	,	PUNCT
brainmatters-990	51	21	ensuring	ensure	VERB
brainmatters-990	51	22	ongoing	ongoing	ADJ
brainmatters-990	51	23	efficacy	efficacy	NOUN
brainmatters-990	51	24	beyond	beyond	ADP
brainmatters-990	51	25	the	the	DET
brainmatters-990	51	26	initial	initial	ADJ
brainmatters-990	51	27	post	post	ADJ
brainmatters-990	51	28	-	-	ADJ
brainmatters-990	51	29	treatment	treatment	NOUN
brainmatters-990	51	30	years	year	NOUN
brainmatters-990	51	31	(	(	PUNCT
brainmatters-990	51	32	ou	ou	X
brainmatters-990	51	33	et	et	PROPN
brainmatters-990	51	34	al	al	PROPN
brainmatters-990	51	35	.	.	PROPN
brainmatters-990	51	36	,	,	PUNCT
brainmatters-990	51	37	2020	2020	NUM
brainmatters-990	51	38	)	)	PUNCT
brainmatters-990	51	39	.	.	PUNCT
brainmatters-990	52	1	using	use	VERB
brainmatters-990	52	2	resting	rest	VERB
brainmatters-990	52	3	state	state	NOUN
brainmatters-990	52	4	functional	functional	ADJ
brainmatters-990	52	5	mri	mri	NOUN
brainmatters-990	52	6	(	(	PUNCT
brainmatters-990	52	7	rs	rs	NOUN
brainmatters-990	52	8	-	-	PUNCT
brainmatters-990	52	9	fmri	fmri	NOUN
brainmatters-990	52	10	)	)	PUNCT
brainmatters-990	52	11	to	to	PART
brainmatters-990	52	12	map	map	VERB
brainmatters-990	52	13	mps	mps	PROPN
brainmatters-990	52	14	i	i	PRON
brainmatters-990	52	15	high	high	ADJ
brainmatters-990	52	16	-	-	PUNCT
brainmatters-990	52	17	resolution	resolution	NOUN
brainmatters-990	52	18	resting	rest	VERB
brainmatters-990	52	19	state	state	NOUN
brainmatters-990	52	20	functional	functional	ADJ
brainmatters-990	52	21	mri	mri	NOUN
brainmatters-990	52	22	(	(	PUNCT
brainmatters-990	52	23	rs	rs	NOUN
brainmatters-990	52	24	-	-	PUNCT
brainmatters-990	52	25	fmri	fmri	ADJ
brainmatters-990	52	26	)	)	PUNCT
brainmatters-990	52	27	emerges	emerge	VERB
brainmatters-990	52	28	as	as	ADP
brainmatters-990	52	29	a	a	DET
brainmatters-990	52	30	non	non	ADJ
brainmatters-990	52	31	-	-	ADJ
brainmatters-990	52	32	invasive	invasive	ADJ
brainmatters-990	52	33	and	and	CCONJ
brainmatters-990	52	34	whole	whole	ADJ
brainmatters-990	52	35	-	-	PUNCT
brainmatters-990	52	36	brain	brain	NOUN
brainmatters-990	52	37	activity	activity	NOUN
brainmatters-990	52	38	imaging	imaging	NOUN
brainmatters-990	52	39	technique	technique	NOUN
brainmatters-990	52	40	for	for	ADP
brainmatters-990	52	41	the	the	DET
brainmatters-990	52	42	diagnosis	diagnosis	NOUN
brainmatters-990	52	43	and	and	CCONJ
brainmatters-990	52	44	post	post	ADJ
brainmatters-990	52	45	-	-	ADJ
brainmatters-990	52	46	treatment	treatment	ADJ
brainmatters-990	52	47	evaluation	evaluation	NOUN
brainmatters-990	52	48	of	of	ADP
brainmatters-990	52	49	mps	mps	PROPN
brainmatters-990	52	50	i.	i.	NOUN
brainmatters-990	52	51	this	this	DET
brainmatters-990	52	52	tool	tool	NOUN
brainmatters-990	52	53	examines	examine	VERB
brainmatters-990	52	54	the	the	DET
brainmatters-990	52	55	spontaneous	spontaneous	ADJ
brainmatters-990	52	56	blood	blood	NOUN
brainmatters-990	52	57	oxygenation	oxygenation	NOUN
brainmatters-990	52	58	level	level	NOUN
brainmatters-990	52	59	-	-	PUNCT
brainmatters-990	52	60	dependent	dependent	ADJ
brainmatters-990	52	61	fluctuations	fluctuation	NOUN
brainmatters-990	52	62	across	across	ADP
brainmatters-990	52	63	various	various	ADJ
brainmatters-990	52	64	brain	brain	NOUN
brainmatters-990	52	65	regions	region	NOUN
brainmatters-990	52	66	without	without	ADP
brainmatters-990	52	67	stimulation	stimulation	NOUN
brainmatters-990	52	68	.	.	PUNCT
brainmatters-990	53	1	clinically	clinically	ADV
brainmatters-990	53	2	,	,	PUNCT
brainmatters-990	53	3	rs	r	NOUN
brainmatters-990	53	4	-	-	PUNCT
brainmatters-990	53	5	fmri	fmri	NOUN
brainmatters-990	53	6	has	have	AUX
brainmatters-990	53	7	successfully	successfully	ADV
brainmatters-990	53	8	identified	identify	VERB
brainmatters-990	53	9	multiple	multiple	ADJ
brainmatters-990	53	10	resting	rest	VERB
brainmatters-990	53	11	state	state	NOUN
brainmatters-990	53	12	networks	network	NOUN
brainmatters-990	53	13	(	(	PUNCT
brainmatters-990	53	14	rsns	rsns	NOUN
brainmatters-990	53	15	)	)	PUNCT
brainmatters-990	53	16	in	in	ADP
brainmatters-990	53	17	conditions	condition	NOUN
brainmatters-990	53	18	such	such	ADJ
brainmatters-990	53	19	as	as	ADP
brainmatters-990	53	20	alzheimer	alzheimer	PROPN
brainmatters-990	53	21	’s	’s	PART
brainmatters-990	53	22	disease	disease	NOUN
brainmatters-990	53	23	,	,	PUNCT
brainmatters-990	53	24	major	major	ADJ
brainmatters-990	53	25	depression	depression	NOUN
brainmatters-990	53	26	,	,	PUNCT
brainmatters-990	53	27	and	and	CCONJ
brainmatters-990	53	28	schizophrenia	schizophrenia	NOUN
brainmatters-990	53	29	.	.	PUNCT
brainmatters-990	54	1	these	these	DET
brainmatters-990	54	2	results	result	NOUN
brainmatters-990	54	3	emphasize	emphasize	VERB
brainmatters-990	54	4	the	the	DET
brainmatters-990	54	5	foundational	foundational	ADJ
brainmatters-990	54	6	role	role	NOUN
brainmatters-990	54	7	of	of	ADP
brainmatters-990	54	8	neural	neural	ADJ
brainmatters-990	54	9	network	network	NOUN
brainmatters-990	54	10	deficits	deficit	NOUN
brainmatters-990	54	11	and	and	CCONJ
brainmatters-990	54	12	interconnectivity	interconnectivity	NOUN
brainmatters-990	54	13	in	in	ADP
brainmatters-990	54	14	certain	certain	ADJ
brainmatters-990	54	15	neurological	neurological	ADJ
brainmatters-990	54	16	disorders	disorder	NOUN
brainmatters-990	54	17	.	.	PUNCT
brainmatters-990	55	1	scientists	scientist	NOUN
brainmatters-990	55	2	at	at	ADP
brainmatters-990	55	3	the	the	DET
brainmatters-990	55	4	university	university	PROPN
brainmatters-990	55	5	of	of	ADP
brainmatters-990	55	6	minnesota	minnesota	PROPN
brainmatters-990	55	7	hypothesized	hypothesize	VERB
brainmatters-990	55	8	that	that	SCONJ
brainmatters-990	55	9	the	the	DET
brainmatters-990	55	10	observed	observed	ADJ
brainmatters-990	55	11	deficits	deficit	NOUN
brainmatters-990	55	12	in	in	ADP
brainmatters-990	55	13	learning	learn	VERB
brainmatters-990	55	14	memory	memory	NOUN
brainmatters-990	55	15	and	and	CCONJ
brainmatters-990	55	16	spatial	spatial	ADJ
brainmatters-990	55	17	navigation	navigation	NOUN
brainmatters-990	55	18	in	in	ADP
brainmatters-990	55	19	mps	mp	NOUN
brainmatters-990	55	20	i	i	PRON
brainmatters-990	55	21	are	be	AUX
brainmatters-990	55	22	influenced	influence	VERB
brainmatters-990	55	23	by	by	ADP
brainmatters-990	55	24	alterations	alteration	NOUN
brainmatters-990	55	25	in	in	ADP
brainmatters-990	55	26	limbic	limbic	ADJ
brainmatters-990	55	27	network	network	NOUN
brainmatters-990	55	28	connectivity	connectivity	NOUN
brainmatters-990	55	29	.	.	PUNCT
brainmatters-990	56	1	hence	hence	ADV
brainmatters-990	56	2	,	,	PUNCT
brainmatters-990	56	3	rs	r	NOUN
brainmatters-990	56	4	-	-	PUNCT
brainmatters-990	56	5	fmri	fmri	PROPN
brainmatters-990	56	6	is	be	AUX
brainmatters-990	56	7	proposed	propose	VERB
brainmatters-990	56	8	as	as	ADP
brainmatters-990	56	9	a	a	DET
brainmatters-990	56	10	sensitive	sensitive	ADJ
brainmatters-990	56	11	imaging	imaging	NOUN
brainmatters-990	56	12	tool	tool	NOUN
brainmatters-990	56	13	to	to	PART
brainmatters-990	56	14	assess	assess	VERB
brainmatters-990	56	15	compromised	compromise	VERB
brainmatters-990	56	16	rsns	rsns	NOUN
brainmatters-990	56	17	in	in	ADP
brainmatters-990	56	18	the	the	DET
brainmatters-990	56	19	figure	figure	NOUN
brainmatters-990	56	20	1	1	NUM
brainmatters-990	56	21	.	.	PUNCT
brainmatters-990	56	22	diagrammatic	diagrammatic	ADJ
brainmatters-990	56	23	representation	representation	NOUN
brainmatters-990	56	24	of	of	ADP
brainmatters-990	56	25	gene	gene	NOUN
brainmatters-990	56	26	therapy	therapy	NOUN
brainmatters-990	56	27	technique	technique	NOUN
brainmatters-990	56	28	(	(	PUNCT
brainmatters-990	56	29	national	national	ADJ
brainmatters-990	56	30	human	human	ADJ
brainmatters-990	56	31	genome	genome	NOUN
brainmatters-990	56	32	research	research	NOUN
brainmatters-990	56	33	institute	institute	NOUN
brainmatters-990	56	34	,	,	PUNCT
brainmatters-990	56	35	2024	2024	NUM
brainmatters-990	56	36	)	)	PUNCT
brainmatters-990	56	37	proprietary	proprietary	ADJ
brainmatters-990	56	38	system	system	NOUN
brainmatters-990	56	39	gene	gene	NOUN
brainmatters-990	56	40	editing	edit	VERB
brainmatters-990	56	41	to	to	PART
brainmatters-990	56	42	treat	treat	VERB
brainmatters-990	56	43	hurler	hurler	ADJ
brainmatters-990	56	44	syndrome	syndrome	NOUN
brainmatters-990	56	45	researchers	researcher	NOUN
brainmatters-990	56	46	at	at	ADP
brainmatters-990	56	47	the	the	DET
brainmatters-990	56	48	university	university	PROPN
brainmatters-990	56	49	of	of	ADP
brainmatters-990	56	50	minnesota	minnesota	PROPN
brainmatters-990	56	51	have	have	AUX
brainmatters-990	56	52	pioneered	pioneer	VERB
brainmatters-990	56	53	a	a	DET
brainmatters-990	56	54	proprietary	proprietary	ADJ
brainmatters-990	56	55	system	system	NOUN
brainmatters-990	56	56	(	(	PUNCT
brainmatters-990	56	57	ps	ps	NOUN
brainmatters-990	56	58	)	)	PUNCT
brainmatters-990	56	59	for	for	ADP
brainmatters-990	56	60	gene	gene	NOUN
brainmatters-990	56	61	editing	editing	NOUN
brainmatters-990	56	62	aimed	aim	VERB
brainmatters-990	56	63	at	at	ADP
brainmatters-990	56	64	treating	treat	VERB
brainmatters-990	56	65	hurler	hurler	ADJ
brainmatters-990	56	66	syndrome	syndrome	NOUN
brainmatters-990	56	67	in	in	ADP
brainmatters-990	56	68	neonatal	neonatal	ADJ
brainmatters-990	56	69	mice	mouse	NOUN
brainmatters-990	56	70	.	.	PUNCT
brainmatters-990	57	1	this	this	DET
brainmatters-990	57	2	innovative	innovative	ADJ
brainmatters-990	57	3	technique	technique	NOUN
brainmatters-990	57	4	,	,	PUNCT
brainmatters-990	57	5	represented	represent	VERB
brainmatters-990	57	6	in	in	ADP
brainmatters-990	57	7	figure	figure	NOUN
brainmatters-990	57	8	2	2	NUM
brainmatters-990	57	9	,	,	PUNCT
brainmatters-990	57	10	involves	involve	VERB
brainmatters-990	57	11	the	the	DET
brainmatters-990	57	12	action	action	NOUN
brainmatters-990	57	13	of	of	ADP
brainmatters-990	57	14	cas9	cas9	NOUN
brainmatters-990	57	15	,	,	PUNCT
brainmatters-990	57	16	which	which	PRON
brainmatters-990	57	17	induces	induce	VERB
brainmatters-990	57	18	a	a	DET
brainmatters-990	57	19	double	double	ADJ
brainmatters-990	57	20	-	-	PUNCT
brainmatters-990	57	21	stranded	strand	VERB
brainmatters-990	57	22	break	break	NOUN
brainmatters-990	57	23	at	at	ADP
brainmatters-990	57	24	the	the	DET
brainmatters-990	57	25	intron	intron	ADJ
brainmatters-990	57	26	1	1	NUM
brainmatters-990	57	27	locus	locus	NOUN
brainmatters-990	57	28	of	of	ADP
brainmatters-990	57	29	liver	liver	NOUN
brainmatters-990	57	30	protein	protein	NOUN
brainmatters-990	57	31	albumin	albumin	NOUN
brainmatters-990	57	32	.	.	PUNCT
brainmatters-990	58	1	simultaneously	simultaneously	ADV
brainmatters-990	58	2	,	,	PUNCT
brainmatters-990	58	3	the	the	DET
brainmatters-990	58	4	guide	guide	NOUN
brainmatters-990	58	5	rna	rna	NOUN
brainmatters-990	58	6	(	(	PUNCT
brainmatters-990	58	7	grna	grna	NOUN
brainmatters-990	58	8	)	)	PUNCT
brainmatters-990	58	9	synthesizes	synthesize	VERB
brainmatters-990	58	10	therapeutic	therapeutic	ADJ
brainmatters-990	58	11	transgene	transgene	ADJ
brainmatters-990	58	12	promoterless	promoterless	NOUN
brainmatters-990	58	13	idua	idua	VERB
brainmatters-990	58	14	cdna	cdna	PROPN
brainmatters-990	58	15	.	.	PUNCT
brainmatters-990	59	1	the	the	DET
brainmatters-990	59	2	method	method	NOUN
brainmatters-990	59	3	employs	employ	VERB
brainmatters-990	59	4	homology	homology	NOUN
brainmatters-990	59	5	-	-	PUNCT
brainmatters-990	59	6	directed	direct	VERB
brainmatters-990	59	7	repair	repair	NOUN
brainmatters-990	59	8	to	to	PART
brainmatters-990	59	9	introduce	introduce	VERB
brainmatters-990	59	10	the	the	DET
brainmatters-990	59	11	splicing	splicing	NOUN
brainmatters-990	59	12	acceptor	acceptor	NOUN
brainmatters-990	59	13	,	,	PUNCT
brainmatters-990	59	14	idua	idua	PROPN
brainmatters-990	59	15	cdna	cdna	PROPN
brainmatters-990	59	16	,	,	PUNCT
brainmatters-990	59	17	and	and	CCONJ
brainmatters-990	59	18	poly(a	poly(a	NOUN
brainmatters-990	59	19	)	)	PUNCT
brainmatters-990	59	20	sequence	sequence	NOUN
brainmatters-990	59	21	into	into	ADP
brainmatters-990	59	22	the	the	DET
brainmatters-990	59	23	target	target	NOUN
brainmatters-990	59	24	,	,	PUNCT
brainmatters-990	59	25	forming	form	VERB
brainmatters-990	59	26	a	a	DET
brainmatters-990	59	27	cohesive	cohesive	ADJ
brainmatters-990	59	28	genetic	genetic	ADJ
brainmatters-990	59	29	structure	structure	NOUN
brainmatters-990	59	30	.	.	PUNCT
brainmatters-990	60	1	alternatively	alternatively	ADV
brainmatters-990	60	2	,	,	PUNCT
brainmatters-990	60	3	nonhomologous	nonhomologous	ADJ
brainmatters-990	60	4	end	end	NOUN
brainmatters-990	60	5	-	-	PUNCT
brainmatters-990	60	6	joining	join	VERB
brainmatters-990	60	7	pathways	pathway	NOUN
brainmatters-990	60	8	come	come	VERB
brainmatters-990	60	9	into	into	ADP
brainmatters-990	60	10	play	play	NOUN
brainmatters-990	60	11	,	,	PUNCT
brainmatters-990	60	12	incorporating	incorporate	VERB
brainmatters-990	60	13	the	the	DET
brainmatters-990	60	14	donor	donor	NOUN
brainmatters-990	60	15	template	template	NOUN
brainmatters-990	60	16	at	at	ADP
brainmatters-990	60	17	the	the	DET
brainmatters-990	60	18	double	double	ADJ
brainmatters-990	60	19	-	-	PUNCT
brainmatters-990	60	20	stranded	strand	VERB
brainmatters-990	60	21	break	break	NOUN
brainmatters-990	60	22	.	.	PUNCT
brainmatters-990	61	1	this	this	DET
brainmatters-990	61	2	results	result	NOUN
brainmatters-990	61	3	in	in	ADP
brainmatters-990	61	4	the	the	DET
brainmatters-990	61	5	creation	creation	NOUN
brainmatters-990	61	6	of	of	ADP
brainmatters-990	61	7	a	a	DET
brainmatters-990	61	8	hybrid	hybrid	ADJ
brainmatters-990	61	9	sequence	sequence	NOUN
brainmatters-990	61	10	of	of	ADP
brainmatters-990	61	11	albumin	albumin	ADJ
brainmatters-990	61	12	exon	exon	PROPN
brainmatters-990	61	13	1	1	NUM
brainmatters-990	61	14	and	and	CCONJ
brainmatters-990	61	15	idua	idua	ADJ
brainmatters-990	61	16	sequence	sequence	NOUN
brainmatters-990	61	17	.	.	PUNCT
brainmatters-990	62	1	therefore	therefore	ADV
brainmatters-990	62	2	,	,	PUNCT
brainmatters-990	62	3	ps	ps	PROPN
brainmatters-990	62	4	gene	gene	NOUN
brainmatters-990	62	5	editing	editing	NOUN
brainmatters-990	62	6	is	be	AUX
brainmatters-990	62	7	versatile	versatile	ADJ
brainmatters-990	62	8	,	,	PUNCT
brainmatters-990	62	9	seamlessly	seamlessly	ADV
brainmatters-990	62	10	functioning	function	VERB
brainmatters-990	62	11	in	in	ADP
brainmatters-990	62	12	both	both	PRON
brainmatters-990	62	13	dividing	divide	VERB
brainmatters-990	62	14	and	and	CCONJ
brainmatters-990	62	15	nondividing	nondivide	VERB
brainmatters-990	62	16	pathways	pathway	NOUN
brainmatters-990	62	17	.	.	PUNCT
brainmatters-990	63	1	figure	figure	NOUN
brainmatters-990	63	2	2	2	NUM
brainmatters-990	63	3	.	.	PUNCT
brainmatters-990	63	4	a	a	DET
brainmatters-990	63	5	diagrammatic	diagrammatic	ADJ
brainmatters-990	63	6	representation	representation	NOUN
brainmatters-990	63	7	of	of	ADP
brainmatters-990	63	8	the	the	DET
brainmatters-990	63	9	molecular	molecular	ADJ
brainmatters-990	63	10	mechanism	mechanism	NOUN
brainmatters-990	63	11	of	of	ADP
brainmatters-990	63	12	ps	ps	NOUN
brainmatters-990	63	13	gene	gene	NOUN
brainmatters-990	63	14	editing	editing	NOUN
brainmatters-990	63	15	(	(	PUNCT
brainmatters-990	63	16	ou	ou	X
brainmatters-990	63	17	et	et	PROPN
brainmatters-990	63	18	al	al	PROPN
brainmatters-990	63	19	.	.	PROPN
brainmatters-990	63	20	2020	2020	NUM
brainmatters-990	63	21	)	)	PUNCT
brainmatters-990	63	22	brain	brain	NOUN
brainmatters-990	63	23	matters・volume	matters・volume	NOUN
brainmatters-990	63	24	vii	vii	PROPN
brainmatters-990	63	25	18	18	NUM
brainmatters-990	63	26	mps	mp	NOUN
brainmatters-990	63	27	i	i	PRON
brainmatters-990	63	28	brain	brain	VERB
brainmatters-990	63	29	and	and	CCONJ
brainmatters-990	63	30	track	track	VERB
brainmatters-990	63	31	their	their	PRON
brainmatters-990	63	32	restoration	restoration	NOUN
brainmatters-990	63	33	following	follow	VERB
brainmatters-990	63	34	gene	gene	NOUN
brainmatters-990	63	35	treatment	treatment	NOUN
brainmatters-990	63	36	.	.	PUNCT
brainmatters-990	64	1	as	as	SCONJ
brainmatters-990	64	2	seen	see	VERB
brainmatters-990	64	3	in	in	ADP
brainmatters-990	64	4	figure	figure	NOUN
brainmatters-990	64	5	3	3	NUM
brainmatters-990	64	6	,	,	PUNCT
brainmatters-990	64	7	in	in	ADP
brainmatters-990	64	8	the	the	DET
brainmatters-990	64	9	realm	realm	NOUN
brainmatters-990	64	10	of	of	ADP
brainmatters-990	64	11	rs	rs	NOUN
brainmatters-990	64	12	-	-	PUNCT
brainmatters-990	64	13	fmri	fmri	NOUN
brainmatters-990	64	14	,	,	PUNCT
brainmatters-990	64	15	the	the	DET
brainmatters-990	64	16	examination	examination	NOUN
brainmatters-990	64	17	of	of	ADP
brainmatters-990	64	18	wild	wild	ADJ
brainmatters-990	64	19	-	-	PUNCT
brainmatters-990	64	20	type	type	NOUN
brainmatters-990	64	21	mice	mouse	NOUN
brainmatters-990	64	22	highlighted	highlight	VERB
brainmatters-990	64	23	robust	robust	ADJ
brainmatters-990	64	24	functional	functional	ADJ
brainmatters-990	64	25	connectivity	connectivity	NOUN
brainmatters-990	64	26	throughout	throughout	ADP
brainmatters-990	64	27	the	the	DET
brainmatters-990	64	28	brain	brain	NOUN
brainmatters-990	64	29	.	.	PUNCT
brainmatters-990	65	1	conversely	conversely	ADV
brainmatters-990	65	2	,	,	PUNCT
brainmatters-990	65	3	mps	mp	NOUN
brainmatters-990	65	4	i	i	PRON
brainmatters-990	65	5	mice	mouse	NOUN
brainmatters-990	65	6	exhibited	exhibit	VERB
brainmatters-990	65	7	weakened	weaken	VERB
brainmatters-990	65	8	and	and	CCONJ
brainmatters-990	65	9	altered	alter	VERB
brainmatters-990	65	10	connections	connection	NOUN
brainmatters-990	65	11	in	in	ADP
brainmatters-990	65	12	crucial	crucial	ADJ
brainmatters-990	65	13	cortical	cortical	ADJ
brainmatters-990	65	14	and	and	CCONJ
brainmatters-990	65	15	subcortical	subcortical	ADJ
brainmatters-990	65	16	regions	region	NOUN
brainmatters-990	65	17	associated	associate	VERB
brainmatters-990	65	18	with	with	ADP
brainmatters-990	65	19	learning	learning	NOUN
brainmatters-990	65	20	,	,	PUNCT
brainmatters-990	65	21	memory	memory	NOUN
brainmatters-990	65	22	,	,	PUNCT
brainmatters-990	65	23	and	and	CCONJ
brainmatters-990	65	24	sensorimotor	sensorimotor	NOUN
brainmatters-990	65	25	behavior	behavior	NOUN
brainmatters-990	65	26	.	.	PUNCT
brainmatters-990	66	1	notably	notably	ADV
brainmatters-990	66	2	,	,	PUNCT
brainmatters-990	66	3	researchers	researcher	NOUN
brainmatters-990	66	4	observed	observe	VERB
brainmatters-990	66	5	a	a	DET
brainmatters-990	66	6	significant	significant	ADJ
brainmatters-990	66	7	loss	loss	NOUN
brainmatters-990	66	8	of	of	ADP
brainmatters-990	66	9	functional	functional	ADJ
brainmatters-990	66	10	connectivity	connectivity	NOUN
brainmatters-990	66	11	in	in	ADP
brainmatters-990	66	12	default	default	NOUN
brainmatters-990	66	13	mode	mode	NOUN
brainmatters-990	66	14	networks	network	NOUN
brainmatters-990	66	15	,	,	PUNCT
brainmatters-990	66	16	including	include	VERB
brainmatters-990	66	17	the	the	DET
brainmatters-990	66	18	retrosplenial	retrosplenial	ADJ
brainmatters-990	66	19	cortex	cortex	NOUN
brainmatters-990	66	20	,	,	PUNCT
brainmatters-990	66	21	thalamus	thalamus	NOUN
brainmatters-990	66	22	,	,	PUNCT
brainmatters-990	66	23	and	and	CCONJ
brainmatters-990	66	24	hippocampus	hippocampus	NOUN
brainmatters-990	66	25	.	.	PUNCT
brainmatters-990	67	1	however	however	ADV
brainmatters-990	67	2	,	,	PUNCT
brainmatters-990	67	3	mps	mps	PROPN
brainmatters-990	67	4	i	i	PRON
brainmatters-990	67	5	mice	mice	VERB
brainmatters-990	67	6	treated	treat	VERB
brainmatters-990	67	7	with	with	ADP
brainmatters-990	67	8	gene	gene	NOUN
brainmatters-990	67	9	therapy	therapy	NOUN
brainmatters-990	67	10	displayed	display	VERB
brainmatters-990	67	11	a	a	DET
brainmatters-990	67	12	restoration	restoration	NOUN
brainmatters-990	67	13	of	of	ADP
brainmatters-990	67	14	functional	functional	ADJ
brainmatters-990	67	15	connections	connection	NOUN
brainmatters-990	67	16	between	between	ADP
brainmatters-990	67	17	the	the	DET
brainmatters-990	67	18	anterior	anterior	ADJ
brainmatters-990	67	19	cingulate	cingulate	NOUN
brainmatters-990	67	20	and	and	CCONJ
brainmatters-990	67	21	motor	motor	NOUN
brainmatters-990	67	22	cortex	cortex	NOUN
brainmatters-990	67	23	,	,	PUNCT
brainmatters-990	67	24	dorsal	dorsal	NOUN
brainmatters-990	67	25	striatum	striatum	NOUN
brainmatters-990	67	26	,	,	PUNCT
brainmatters-990	67	27	and	and	CCONJ
brainmatters-990	67	28	hippocampus	hippocampus	NOUN
brainmatters-990	67	29	.	.	PUNCT
brainmatters-990	68	1	the	the	DET
brainmatters-990	68	2	rs	rs	ADJ
brainmatters-990	68	3	-	-	PUNCT
brainmatters-990	68	4	fmri	fmri	ADJ
brainmatters-990	68	5	findings	finding	NOUN
brainmatters-990	68	6	reinforce	reinforce	VERB
brainmatters-990	68	7	the	the	DET
brainmatters-990	68	8	notion	notion	NOUN
brainmatters-990	68	9	that	that	SCONJ
brainmatters-990	68	10	hurler	hurler	NOUN
brainmatters-990	68	11	syndrome	syndrome	NOUN
brainmatters-990	68	12	impacts	impact	NOUN
brainmatters-990	68	13	synapse	synapse	VERB
brainmatters-990	68	14	formation	formation	NOUN
brainmatters-990	68	15	,	,	PUNCT
brainmatters-990	68	16	leading	lead	VERB
brainmatters-990	68	17	to	to	ADP
brainmatters-990	68	18	diminished	diminish	VERB
brainmatters-990	68	19	neural	neural	ADJ
brainmatters-990	68	20	connectivity	connectivity	NOUN
brainmatters-990	68	21	.	.	PUNCT
brainmatters-990	69	1	the	the	DET
brainmatters-990	69	2	observed	observe	VERB
brainmatters-990	69	3	dysfunction	dysfunction	NOUN
brainmatters-990	69	4	in	in	ADP
brainmatters-990	69	5	hippocampal	hippocampal	ADJ
brainmatters-990	69	6	connectivity	connectivity	NOUN
brainmatters-990	69	7	with	with	ADP
brainmatters-990	69	8	the	the	DET
brainmatters-990	69	9	retrosplenial	retrosplenial	ADJ
brainmatters-990	69	10	cortex	cortex	NOUN
brainmatters-990	69	11	holds	hold	VERB
brainmatters-990	69	12	implications	implication	NOUN
brainmatters-990	69	13	for	for	ADP
brainmatters-990	69	14	spatial	spatial	ADJ
brainmatters-990	69	15	navigation	navigation	NOUN
brainmatters-990	69	16	performance	performance	NOUN
brainmatters-990	69	17	.	.	PUNCT
brainmatters-990	70	1	these	these	DET
brainmatters-990	70	2	results	result	NOUN
brainmatters-990	70	3	bear	bear	VERB
brainmatters-990	70	4	clinical	clinical	ADJ
brainmatters-990	70	5	relevance	relevance	NOUN
brainmatters-990	70	6	for	for	ADP
brainmatters-990	70	7	the	the	DET
brainmatters-990	70	8	diagnosis	diagnosis	NOUN
brainmatters-990	70	9	,	,	PUNCT
brainmatters-990	70	10	monitoring	monitoring	NOUN
brainmatters-990	70	11	,	,	PUNCT
brainmatters-990	70	12	and	and	CCONJ
brainmatters-990	70	13	treatment	treatment	NOUN
brainmatters-990	70	14	of	of	ADP
brainmatters-990	70	15	hurler	hurler	NOUN
brainmatters-990	70	16	syndrome	syndrome	NOUN
brainmatters-990	70	17	.	.	PUNCT
brainmatters-990	71	1	furthermore	furthermore	ADV
brainmatters-990	71	2	,	,	PUNCT
brainmatters-990	71	3	rs	rs	ADJ
brainmatters-990	71	4	-	-	PUNCT
brainmatters-990	71	5	fmri	fmri	NOUN
brainmatters-990	71	6	’s	’s	PART
brainmatters-990	71	7	translational	translational	ADJ
brainmatters-990	71	8	potential	potential	NOUN
brainmatters-990	71	9	extends	extend	VERB
brainmatters-990	71	10	to	to	ADP
brainmatters-990	71	11	the	the	DET
brainmatters-990	71	12	clinical	clinical	ADJ
brainmatters-990	71	13	analysis	analysis	NOUN
brainmatters-990	71	14	of	of	ADP
brainmatters-990	71	15	other	other	ADJ
brainmatters-990	71	16	human	human	ADJ
brainmatters-990	71	17	neurological	neurological	ADJ
brainmatters-990	71	18	disorders	disorder	NOUN
brainmatters-990	71	19	and	and	CCONJ
brainmatters-990	71	20	gene	gene	NOUN
brainmatters-990	71	21	therapy	therapy	NOUN
brainmatters-990	71	22	outcomes	outcome	NOUN
brainmatters-990	71	23	(	(	PUNCT
brainmatters-990	71	24	zhu	zhu	X
brainmatters-990	71	25	et	et	PROPN
brainmatters-990	71	26	al	al	PROPN
brainmatters-990	71	27	.	.	PROPN
brainmatters-990	71	28	,	,	PUNCT
brainmatters-990	71	29	2023	2023	NUM
brainmatters-990	71	30	)	)	PUNCT
brainmatters-990	71	31	.	.	PUNCT
brainmatters-990	72	1	conclusion	conclusion	NOUN
brainmatters-990	72	2	this	this	DET
brainmatters-990	72	3	comprehensive	comprehensive	ADJ
brainmatters-990	72	4	exploration	exploration	NOUN
brainmatters-990	72	5	provides	provide	VERB
brainmatters-990	72	6	valuable	valuable	ADJ
brainmatters-990	72	7	insights	insight	NOUN
brainmatters-990	72	8	into	into	ADP
brainmatters-990	72	9	hurler	hurler	NOUN
brainmatters-990	72	10	syndrome	syndrome	NOUN
brainmatters-990	72	11	and	and	CCONJ
brainmatters-990	72	12	underscores	underscore	VERB
brainmatters-990	72	13	the	the	DET
brainmatters-990	72	14	promising	promising	ADJ
brainmatters-990	72	15	avenues	avenue	NOUN
brainmatters-990	72	16	offered	offer	VERB
brainmatters-990	72	17	by	by	ADP
brainmatters-990	72	18	gene	gene	NOUN
brainmatters-990	72	19	therapy	therapy	NOUN
brainmatters-990	72	20	,	,	PUNCT
brainmatters-990	72	21	particularly	particularly	ADV
brainmatters-990	72	22	through	through	ADP
brainmatters-990	72	23	ps	ps	NOUN
brainmatters-990	72	24	gene	gene	NOUN
brainmatters-990	72	25	editing	editing	NOUN
brainmatters-990	72	26	.	.	PUNCT
brainmatters-990	73	1	traditional	traditional	ADJ
brainmatters-990	73	2	treatments	treatment	NOUN
brainmatters-990	73	3	for	for	ADP
brainmatters-990	73	4	hurler	hurler	NOUN
brainmatters-990	73	5	syndrome	syndrome	NOUN
brainmatters-990	73	6	emphasize	emphasize	VERB
brainmatters-990	73	7	the	the	DET
brainmatters-990	73	8	necessity	necessity	NOUN
brainmatters-990	73	9	for	for	ADP
brainmatters-990	73	10	more	more	ADV
brainmatters-990	73	11	targeted	target	VERB
brainmatters-990	73	12	interventions	intervention	NOUN
brainmatters-990	73	13	addressing	address	VERB
brainmatters-990	73	14	the	the	DET
brainmatters-990	73	15	root	root	NOUN
brainmatters-990	73	16	cause	cause	NOUN
brainmatters-990	73	17	,	,	PUNCT
brainmatters-990	73	18	and	and	CCONJ
brainmatters-990	73	19	gene	gene	NOUN
brainmatters-990	73	20	therapy	therapy	NOUN
brainmatters-990	73	21	,	,	PUNCT
brainmatters-990	73	22	a	a	DET
brainmatters-990	73	23	burgeoning	burgeon	VERB
brainmatters-990	73	24	field	field	NOUN
brainmatters-990	73	25	with	with	ADP
brainmatters-990	73	26	transformative	transformative	ADJ
brainmatters-990	73	27	potential	potential	NOUN
brainmatters-990	73	28	,	,	PUNCT
brainmatters-990	73	29	emerges	emerge	VERB
brainmatters-990	73	30	as	as	ADP
brainmatters-990	73	31	a	a	DET
brainmatters-990	73	32	beacon	beacon	NOUN
brainmatters-990	73	33	of	of	ADP
brainmatters-990	73	34	hope	hope	NOUN
brainmatters-990	73	35	.	.	PUNCT
brainmatters-990	74	1	ps	ps	NOUN
brainmatters-990	74	2	gene	gene	NOUN
brainmatters-990	74	3	editing	editing	NOUN
brainmatters-990	74	4	marks	mark	VERB
brainmatters-990	74	5	a	a	DET
brainmatters-990	74	6	significant	significant	ADJ
brainmatters-990	74	7	stride	stride	NOUN
brainmatters-990	74	8	in	in	ADP
brainmatters-990	74	9	pursuing	pursue	VERB
brainmatters-990	74	10	effective	effective	ADJ
brainmatters-990	74	11	and	and	CCONJ
brainmatters-990	74	12	sustainable	sustainable	ADJ
brainmatters-990	74	13	treatments	treatment	NOUN
brainmatters-990	74	14	for	for	ADP
brainmatters-990	74	15	hurler	hurler	NOUN
brainmatters-990	74	16	syndrome	syndrome	NOUN
brainmatters-990	74	17	.	.	PUNCT
brainmatters-990	75	1	the	the	DET
brainmatters-990	75	2	insights	insight	NOUN
brainmatters-990	75	3	gained	gain	VERB
brainmatters-990	75	4	from	from	ADP
brainmatters-990	75	5	rs	rs	ADJ
brainmatters-990	75	6	-	-	PUNCT
brainmatters-990	75	7	fmri	fmri	NOUN
brainmatters-990	75	8	not	not	PART
brainmatters-990	75	9	only	only	ADV
brainmatters-990	75	10	enhance	enhance	VERB
brainmatters-990	75	11	our	our	PRON
brainmatters-990	75	12	understanding	understanding	NOUN
brainmatters-990	75	13	of	of	ADP
brainmatters-990	75	14	the	the	DET
brainmatters-990	75	15	neurological	neurological	ADJ
brainmatters-990	75	16	deficits	deficit	NOUN
brainmatters-990	75	17	associated	associate	VERB
brainmatters-990	75	18	with	with	ADP
brainmatters-990	75	19	figure	figure	NOUN
brainmatters-990	75	20	3	3	NUM
brainmatters-990	75	21	.	.	PUNCT
brainmatters-990	76	1	correlation	correlation	NOUN
brainmatters-990	76	2	matrices	matrix	NOUN
brainmatters-990	76	3	and	and	CCONJ
brainmatters-990	76	4	circular	circular	ADJ
brainmatters-990	76	5	graphs	graph	NOUN
brainmatters-990	76	6	of	of	ADP
brainmatters-990	76	7	functional	functional	ADJ
brainmatters-990	76	8	brain	brain	NOUN
brainmatters-990	76	9	connections	connection	NOUN
brainmatters-990	76	10	between	between	ADP
brainmatters-990	76	11	(	(	PUNCT
brainmatters-990	76	12	a	a	PRON
brainmatters-990	76	13	)	)	PUNCT
brainmatters-990	76	14	control	control	NOUN
brainmatters-990	76	15	,	,	PUNCT
brainmatters-990	76	16	(	(	PUNCT
brainmatters-990	76	17	b	b	X
brainmatters-990	76	18	)	)	PUNCT
brainmatters-990	76	19	mps	mps	PROPN
brainmatters-990	76	20	i	i	PRON
brainmatters-990	76	21	,	,	PUNCT
brainmatters-990	76	22	and	and	CCONJ
brainmatters-990	76	23	(	(	PUNCT
brainmatters-990	76	24	c	c	X
brainmatters-990	76	25	)	)	PUNCT
brainmatters-990	76	26	mps	mp	NOUN
brainmatters-990	76	27	i	i	PRON
brainmatters-990	76	28	treated	treat	VERB
brainmatters-990	76	29	mice	mouse	NOUN
brainmatters-990	76	30	.	.	PUNCT
brainmatters-990	77	1	blue	blue	ADJ
brainmatters-990	77	2	-	-	PUNCT
brainmatters-990	77	3	connectome	connectome	PROPN
brainmatters-990	77	4	with	with	ADP
brainmatters-990	77	5	connections	connection	NOUN
brainmatters-990	77	6	at	at	ADP
brainmatters-990	77	7	anterior	anterior	ADJ
brainmatters-990	77	8	cingulate	cingulate	NOUN
brainmatters-990	77	9	area	area	NOUN
brainmatters-990	77	10	,	,	PUNCT
brainmatters-990	77	11	greenconnectome	greenconnectome	VERB
brainmatters-990	77	12	with	with	ADP
brainmatters-990	77	13	connections	connection	NOUN
brainmatters-990	77	14	at	at	ADP
brainmatters-990	77	15	ammon	ammon	PROPN
brainmatters-990	77	16	’s	’s	PART
brainmatters-990	77	17	horn	horn	NOUN
brainmatters-990	77	18	,	,	PUNCT
brainmatters-990	77	19	and	and	CCONJ
brainmatters-990	77	20	yellow	yellow	ADJ
brainmatters-990	77	21	-	-	PUNCT
brainmatters-990	77	22	connectome	connectome	PROPN
brainmatters-990	77	23	with	with	ADP
brainmatters-990	77	24	connections	connection	NOUN
brainmatters-990	77	25	at	at	ADP
brainmatters-990	77	26	mediodorsal	mediodorsal	PROPN
brainmatters-990	77	27	nucleus	nucleus	PROPN
brainmatters-990	77	28	of	of	ADP
brainmatters-990	77	29	thalamus	thalamus	PROPN
brainmatters-990	77	30	.	.	PUNCT
brainmatters-990	78	1	brain	brain	NOUN
brainmatters-990	78	2	connectome	connectome	PROPN
brainmatters-990	78	3	is	be	AUX
brainmatters-990	78	4	sporadic	sporadic	ADJ
brainmatters-990	78	5	for	for	ADP
brainmatters-990	78	6	mutant	mutant	NOUN
brainmatters-990	78	7	but	but	CCONJ
brainmatters-990	78	8	recovers	recover	NOUN
brainmatters-990	78	9	after	after	ADP
brainmatters-990	78	10	treatment	treatment	NOUN
brainmatters-990	78	11	.	.	PUNCT
brainmatters-990	79	1	(	(	PUNCT
brainmatters-990	79	2	zhu	zhu	X
brainmatters-990	79	3	et	et	PROPN
brainmatters-990	79	4	al	al	PROPN
brainmatters-990	79	5	.	.	PROPN
brainmatters-990	79	6	,	,	PUNCT
brainmatters-990	79	7	2023	2023	NUM
brainmatters-990	79	8	)	)	PUNCT
brainmatters-990	79	9	hurler	hurler	NOUN
brainmatters-990	79	10	syndrome	syndrome	NOUN
brainmatters-990	79	11	but	but	CCONJ
brainmatters-990	79	12	position	position	VERB
brainmatters-990	79	13	rs	rs	NOUN
brainmatters-990	79	14	-	-	PUNCT
brainmatters-990	79	15	fmri	fmri	NOUN
brainmatters-990	79	16	as	as	ADP
brainmatters-990	79	17	a	a	DET
brainmatters-990	79	18	promising	promising	ADJ
brainmatters-990	79	19	diagnostic	diagnostic	ADJ
brainmatters-990	79	20	and	and	CCONJ
brainmatters-990	79	21	therapeutic	therapeutic	ADJ
brainmatters-990	79	22	imaging	imaging	NOUN
brainmatters-990	79	23	technique	technique	NOUN
brainmatters-990	79	24	.	.	PUNCT
brainmatters-990	80	1	as	as	SCONJ
brainmatters-990	80	2	scientists	scientist	NOUN
brainmatters-990	80	3	navigate	navigate	VERB
brainmatters-990	80	4	this	this	DET
brainmatters-990	80	5	frontier	frontier	NOUN
brainmatters-990	80	6	of	of	ADP
brainmatters-990	80	7	knowledge	knowledge	NOUN
brainmatters-990	80	8	,	,	PUNCT
brainmatters-990	80	9	the	the	DET
brainmatters-990	80	10	potential	potential	NOUN
brainmatters-990	80	11	for	for	ADP
brainmatters-990	80	12	transformative	transformative	ADJ
brainmatters-990	80	13	breakthroughs	breakthrough	NOUN
brainmatters-990	80	14	in	in	ADP
brainmatters-990	80	15	treating	treat	VERB
brainmatters-990	80	16	hurler	hurler	ADJ
brainmatters-990	80	17	syndrome	syndrome	NOUN
brainmatters-990	80	18	and	and	CCONJ
brainmatters-990	80	19	related	related	ADJ
brainmatters-990	80	20	disorders	disorder	NOUN
brainmatters-990	80	21	becomes	become	VERB
brainmatters-990	80	22	increasingly	increasingly	ADV
brainmatters-990	80	23	tangible	tangible	ADJ
brainmatters-990	80	24	.	.	PUNCT
brainmatters-990	81	1	references	reference	NOUN
brainmatters-990	81	2	1	1	NUM
brainmatters-990	81	3	.	.	X
brainmatters-990	81	4	concolino	concolino	PROPN
brainmatters-990	81	5	,	,	PUNCT
brainmatters-990	81	6	d.	d.	PROPN
brainmatters-990	81	7	,	,	PUNCT
brainmatters-990	81	8	deodato	deodato	PROPN
brainmatters-990	81	9	,	,	PUNCT
brainmatters-990	81	10	f.	f.	PROPN
brainmatters-990	81	11	,	,	PUNCT
brainmatters-990	81	12	&	&	CCONJ
brainmatters-990	81	13	parini	parini	PROPN
brainmatters-990	81	14	,	,	PUNCT
brainmatters-990	81	15	r.	r.	PROPN
brainmatters-990	81	16	(	(	PUNCT
brainmatters-990	81	17	2018	2018	NUM
brainmatters-990	81	18	)	)	PUNCT
brainmatters-990	81	19	.	.	PUNCT
brainmatters-990	82	1	enzyme	enzyme	NOUN
brainmatters-990	82	2	replacement	replacement	NOUN
brainmatters-990	82	3	therapy	therapy	NOUN
brainmatters-990	82	4	:	:	PUNCT
brainmatters-990	82	5	efficacy	efficacy	NOUN
brainmatters-990	82	6	and	and	CCONJ
brainmatters-990	82	7	lmitations	lmitation	NOUN
brainmatters-990	82	8	.	.	PUNCT
brainmatters-990	83	1	italian	italian	ADJ
brainmatters-990	83	2	journal	journal	NOUN
brainmatters-990	83	3	of	of	ADP
brainmatters-990	83	4	pediatrics	pediatric	NOUN
brainmatters-990	83	5	,	,	PUNCT
brainmatters-990	83	6	44(supply	44(supply	NUM
brainmatters-990	83	7	,	,	PUNCT
brainmatters-990	83	8	120	120	NUM
brainmatters-990	83	9	.	.	PUNCT
brainmatters-990	84	1	https://doi.org/10.1186/s13052018-0562-1	https://doi.org/10.1186/s13052018-0562-1	PROPN
brainmatters-990	84	2	gene	gene	NOUN
brainmatters-990	84	3	therapy	therapy	NOUN
brainmatters-990	84	4	.	.	PUNCT
brainmatters-990	85	1	genome.gov	genome.gov	X
brainmatters-990	85	2	.	.	PUNCT
brainmatters-990	85	3	(	(	PUNCT
brainmatters-990	85	4	n.d.-a	n.d.-a	NOUN
brainmatters-990	85	5	)	)	PUNCT
brainmatters-990	85	6	.	.	PUNCT
brainmatters-990	86	1	https://www.genome.gov/geneticsglossary/gene-therapy	https://www.genome.gov/geneticsglossary/gene-therapy	NUM
brainmatters-990	86	2	2	2	NUM
brainmatters-990	86	3	.	.	PUNCT
brainmatters-990	86	4	mayo	mayo	PROPN
brainmatters-990	86	5	foundation	foundation	PROPN
brainmatters-990	86	6	for	for	ADP
brainmatters-990	86	7	medical	medical	ADJ
brainmatters-990	86	8	education	education	NOUN
brainmatters-990	86	9	and	and	CCONJ
brainmatters-990	86	10	research	research	NOUN
brainmatters-990	86	11	.	.	PUNCT
brainmatters-990	87	1	(	(	PUNCT
brainmatters-990	87	2	2017	2017	NUM
brainmatters-990	87	3	,	,	PUNCT
brainmatters-990	87	4	december	december	PROPN
brainmatters-990	87	5	.	.	PUNCT
brainmatters-990	88	1	gene	gene	NOUN
brainmatters-990	88	2	therapy	therapy	NOUN
brainmatters-990	88	3	.	.	PUNCT
brainmatters-990	89	1	mayo	mayo	NOUN
brainmatters-990	89	2	-	-	PUNCT
brainmatters-990	89	3	clinic	clinic	NOUN
brainmatters-990	89	4	.	.	PUNCT
brainmatters-990	90	1	https://www.mayoclinic.org/tests-procedures/genet	https://www.mayoclinic.org/tests-procedures/genet	PROPN
brainmatters-990	90	2	herapy	herapy	PROPN
brainmatters-990	90	3	/	/	SYM
brainmatters-990	90	4	about	about	ADP
brainmatters-990	90	5	/	/	SYM
brainmatters-990	90	6	pac20384619	pac20384619	NOUN
brainmatters-990	90	7	3	3	NUM
brainmatters-990	90	8	.	.	X
brainmatters-990	90	9	ou	ou	PROPN
brainmatters-990	90	10	,	,	PUNCT
brainmatters-990	90	11	l.	l.	PROPN
brainmatters-990	90	12	,	,	PUNCT
brainmatters-990	90	13	przybilla	przybilla	NOUN
brainmatters-990	90	14	,	,	PUNCT
brainmatters-990	90	15	m.	m.	NOUN
brainmatters-990	90	16	j.	j.	PROPN
brainmatters-990	90	17	,	,	PUNCT
brainmatters-990	90	18	ahlat	ahlat	ADJ
brainmatters-990	90	19	,	,	PUNCT
brainmatters-990	90	20	o.	o.	PROPN
brainmatters-990	90	21	,	,	PUNCT
brainmatters-990	90	22	kim	kim	PROPN
brainmatters-990	90	23	,	,	PUNCT
brainmatters-990	90	24	s.	s.	PROPN
brainmatters-990	90	25	,	,	PUNCT
brainmatters-990	90	26	overn	overn	NOUN
brainmatters-990	90	27	,	,	PUNCT
brainmatters-990	90	28	p.	p.	NOUN
brainmatters-990	90	29	,	,	PUNCT
brainmatters-990	90	30	jarnes	jarnes	PROPN
brainmatters-990	90	31	,	,	PUNCT
brainmatters-990	90	32	j.	j.	PROPN
brainmatters-990	90	33	,	,	PUNCT
brainmatters-990	90	34	o’sullivan	o’sullivan	PROPN
brainmatters-990	90	35	,	,	PUNCT
brainmatters-990	90	36	m.	m.	NOUN
brainmatters-990	90	37	g.	g.	PROPN
brainmatters-990	90	38	,	,	PUNCT
brainmatters-990	90	39	&	&	CCONJ
brainmatters-990	90	40	whitley	whitley	PROPN
brainmatters-990	90	41	,	,	PUNCT
brainmatters-990	90	42	c.	c.	PROPN
brainmatters-990	90	43	b.	b.	PROPN
brainmatters-990	90	44	(	(	PUNCT
brainmatters-990	90	45	2020	2020	NUM
brainmatters-990	90	46	,	,	PUNCT
brainmatters-990	90	47	june	june	PROPN
brainmatters-990	90	48	3	3	NUM
brainmatters-990	90	49	)	)	PUNCT
brainmatters-990	90	50	.	.	PUNCT
brainmatters-990	91	1	a	a	DET
brainmatters-990	91	2	highly	highly	ADV
brainmatters-990	91	3	efficacious	efficacious	ADJ
brainmatters-990	91	4	ps	ps	NOUN
brainmatters-990	91	5	gene	gene	NOUN
brainmatters-990	91	6	editing	edit	VERB
brainmatters-990	91	7	system	system	NOUN
brainmatters-990	91	8	corrects	correct	NOUN
brainmatters-990	91	9	metabolic	metabolic	NOUN
brainmatters-990	91	10	and	and	CCONJ
brainmatters-990	91	11	neurological	neurological	ADJ
brainmatters-990	91	12	complications	complication	NOUN
brainmatters-990	91	13	of	of	ADP
brainmatters-990	91	14	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
brainmatters-990	91	15	type	type	NOUN
brainmatters-990	91	16	i.	i.	PROPN
brainmatters-990	91	17	molecular	molecular	PROPN
brainmatters-990	91	18	therapy	therapy	NOUN
brainmatters-990	91	19	:	:	PUNCT
brainmatters-990	91	20	the	the	DET
brainmatters-990	91	21	journal	journal	NOUN
brainmatters-990	91	22	of	of	ADP
brainmatters-990	91	23	the	the	DET
brainmatters-990	91	24	american	american	ADJ
brainmatters-990	91	25	society	society	NOUN
brainmatters-990	91	26	of	of	ADP
brainmatters-990	91	27	gene	gene	NOUN
brainmatters-990	91	28	therapy	therapy	NOUN
brainmatters-990	91	29	.	.	PUNCT
brainmatters-990	92	1	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7264433/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7264433/	PRON
brainmatters-990	92	2	4	4	NUM
brainmatters-990	92	3	.	.	X
brainmatters-990	92	4	rajkumar	rajkumar	PROPN
brainmatters-990	92	5	,	,	PUNCT
brainmatters-990	92	6	v.	v.	PROPN
brainmatters-990	92	7	,	,	PUNCT
brainmatters-990	92	8	&	&	CCONJ
brainmatters-990	92	9	dumpa	dumpa	PROPN
brainmatters-990	92	10	,	,	PUNCT
brainmatters-990	92	11	v.	v.	PROPN
brainmatters-990	92	12	(	(	PUNCT
brainmatters-990	92	13	2023	2023	NUM
brainmatters-990	92	14	,	,	PUNCT
brainmatters-990	92	15	july	july	PROPN
brainmatters-990	92	16	24	24	NUM
brainmatters-990	92	17	)	)	PUNCT
brainmatters-990	92	18	.	.	PUNCT
brainmatters-990	93	1	lysosomal	lysosomal	ADJ
brainmatters-990	93	2	storage	storage	NOUN
brainmatters-990	93	3	disease	disease	NOUN
brainmatters-990	93	4	statpearls	statpearl	VERB
brainmatters-990	93	5	ncbi	ncbi	PROPN
brainmatters-990	93	6	bookshelf	bookshelf	PROPN
brainmatters-990	93	7	.	.	PUNCT
brainmatters-990	94	1	national	national	PROPN
brainmatters-990	94	2	library	library	NOUN
brainmatters-990	94	3	of	of	ADP
brainmatters-990	94	4	medicinenational	medicinenational	ADJ
brainmatters-990	94	5	center	center	NOUN
brainmatters-990	94	6	for	for	ADP
brainmatters-990	94	7	biotechnology	biotechnology	NOUN
brainmatters-990	94	8	information	information	NOUN
brainmatters-990	94	9	.	.	PUNCT
brainmatters-990	95	1	https://www.ncbi.nlm.nih.gov/books/nbk563270/	https://www.ncbi.nlm.nih.gov/books/nbk563270/	PROPN
brainmatters-990	95	2	5	5	NUM
brainmatters-990	95	3	.	.	PUNCT
brainmatters-990	95	4	sakuru	sakuru	PROPN
brainmatters-990	95	5	,	,	PUNCT
brainmatters-990	95	6	r.	r.	PROPN
brainmatters-990	95	7	,	,	PUNCT
brainmatters-990	95	8	&	&	CCONJ
brainmatters-990	95	9	bollu	bollu	PROPN
brainmatters-990	95	10	,	,	PUNCT
brainmatters-990	95	11	p.	p.	PROPN
brainmatters-990	95	12	c.	c.	PROPN
brainmatters-990	95	13	(	(	PUNCT
brainmatters-990	95	14	2023	2023	NUM
brainmatters-990	95	15	,	,	PUNCT
brainmatters-990	95	16	july	july	PROPN
brainmatters-990	95	17	10	10	NUM
brainmatters-990	95	18	)	)	PUNCT
brainmatters-990	95	19	.	.	PUNCT
brainmatters-990	96	1	hurler	hurler	NOUN
brainmatters-990	96	2	syndrome	syndrome	PROPN
brainmatters-990	96	3	–	–	PUNCT
brainmatters-990	96	4	statpearls	statpearl	NOUN
brainmatters-990	96	5	–	–	PUNCT
brainmatters-990	96	6	ncbi	ncbi	PROPN
brainmatters-990	96	7	bookshelf	bookshelf	PROPN
brainmatters-990	96	8	.	.	PUNCT
brainmatters-990	97	1	national	national	PROPN
brainmatters-990	97	2	library	library	NOUN
brainmatters-990	97	3	of	of	ADP
brainmatters-990	97	4	medicinenational	medicinenational	ADJ
brainmatters-990	97	5	center	center	NOUN
brainmatters-990	97	6	for	for	ADP
brainmatters-990	97	7	biotechnology	biotechnology	NOUN
brainmatters-990	97	8	information	information	NOUN
brainmatters-990	97	9	.	.	PUNCT
brainmatters-990	98	1	https://www.ncbi.nlm.nih.gov/books/nbk532261/	https://www.ncbi.nlm.nih.gov/books/nbk532261/	PROPN
brainmatters-990	98	2	6	6	NUM
brainmatters-990	98	3	.	.	PUNCT
brainmatters-990	99	1	zhu	zhu	PROPN
brainmatters-990	99	2	,	,	PUNCT
brainmatters-990	99	3	w.	w.	PROPN
brainmatters-990	99	4	,	,	PUNCT
brainmatters-990	99	5	ou	ou	PROPN
brainmatters-990	99	6	,	,	PUNCT
brainmatters-990	99	7	l.	l.	PROPN
brainmatters-990	99	8	,	,	PUNCT
brainmatters-990	99	9	zhang	zhang	PROPN
brainmatters-990	99	10	,	,	PUNCT
brainmatters-990	99	11	l.	l.	PROPN
brainmatters-990	99	12	,	,	PUNCT
brainmatters-990	99	13	clark	clark	PROPN
brainmatters-990	99	14	,	,	PUNCT
brainmatters-990	99	15	i.	i.	PROPN
brainmatters-990	99	16	h.	h.	PROPN
brainmatters-990	99	17	,	,	PUNCT
brainmatters-990	99	18	zhang	zhang	PROPN
brainmatters-990	99	19	,	,	PUNCT
brainmatters-990	99	20	y.	y.	PROPN
brainmatters-990	99	21	,	,	PUNCT
brainmatters-990	99	22	zhu	zhu	PROPN
brainmatters-990	99	23	,	,	PUNCT
brainmatters-990	99	24	x.	x.	PROPN
brainmatters-990	99	25	h.	h.	PROPN
brainmatters-990	99	26	,	,	PUNCT
brainmatters-990	99	27	whitley	whitley	PROPN
brainmatters-990	99	28	,	,	PUNCT
brainmatters-990	99	29	c.	c.	PROPN
brainmatters-990	99	30	b.	b.	PROPN
brainmatters-990	99	31	,	,	PUNCT
brainmatters-990	99	32	hackett	hackett	PROPN
brainmatters-990	99	33	,	,	PUNCT
brainmatters-990	99	34	p.	p.	PROPN
brainmatters-990	99	35	b.	b.	PROPN
brainmatters-990	100	1	,low	,low	PROPN
brainmatters-990	100	2	,	,	PUNCT
brainmatters-990	100	3	w.	w.	PROPN
brainmatters-990	100	4	c.	c.	PROPN
brainmatters-990	100	5	,	,	PUNCT
brainmatters-990	100	6	&	&	CCONJ
brainmatters-990	100	7	chen	chen	PROPN
brainmatters-990	100	8	,	,	PUNCT
brainmatters-990	100	9	w.	w.	PROPN
brainmatters-990	100	10	(	(	PUNCT
brainmatters-990	100	11	2023	2023	NUM
brainmatters-990	100	12	)	)	PUNCT
brainmatters-990	100	13	.	.	PUNCT
brainmatters-990	101	1	mapping	map	VERB
brainmatters-990	101	2	brain	brain	NOUN
brainmatters-990	101	3	networks	network	NOUN
brainmatters-990	101	4	in	in	ADP
brainmatters-990	101	5	mps	mp	NOUN
brainmatters-990	101	6	i	i	PRON
brainmatters-990	101	7	mice	mice	VERB
brainmatters-990	101	8	and	and	CCONJ
brainmatters-990	101	9	their	their	PRON
brainmatters-990	101	10	restoration	restoration	NOUN
brainmatters-990	101	11	following	follow	VERB
brainmatters-990	101	12	gene	gene	NOUN
brainmatters-990	101	13	therapy	therapy	NOUN
brainmatters-990	101	14	.	.	PUNCT
brainmatters-990	102	1	scientific	scientific	ADJ
brainmatters-990	102	2	reports	report	NOUN
brainmatters-990	102	3	,	,	PUNCT
brainmatters-990	102	4	13(1	13(1	NUM
brainmatters-990	102	5	)	)	PUNCT
brainmatters-990	102	6	,	,	PUNCT
brainmatters-990	102	7	12716	12716	NUM
brainmatters-990	102	8	.	.	PUNCT
brainmatters-990	103	1	https://doi.org/10.1038/s41598-023-39939-0	https://doi.org/10.1038/s41598-023-39939-0	NUM
brainmatters-990	103	2	brain	brain	NOUN
brainmatters-990	103	3	matters・volume	matters・volume	PROPN
brainmatters-990	103	4	vii	vii	PROPN
brainmatters-990	103	5	20	20	NUM