id	sid	tid	token	lemma	pos
brainmatters-996	1	1	volume	volume	NOUN
brainmatters-996	1	2	8	8	NUM
brainmatters-996	1	3	(	(	PUNCT
brainmatters-996	1	4	will	will	AUX
brainmatters-996	1	5	be	be	AUX
brainmatters-996	1	6	vol	vol	NOUN
brainmatters-996	1	7	7	7	NUM
brainmatters-996	1	8	on	on	ADP
brainmatters-996	1	9	site	site	NOUN
brainmatters-996	1	10	)	)	PUNCT
brainmatters-996	1	11	what	what	PRON
brainmatters-996	1	12	is	be	AUX
brainmatters-996	1	13	gbm	gbm	PROPN
brainmatters-996	1	14	?	?	PUNCT
brainmatters-996	2	1	gbm	gbm	NOUN
brainmatters-996	2	2	is	be	AUX
brainmatters-996	2	3	a	a	DET
brainmatters-996	2	4	type	type	NOUN
brainmatters-996	2	5	of	of	ADP
brainmatters-996	2	6	glioma	glioma	NOUN
brainmatters-996	2	7	.	.	PUNCT
brainmatters-996	3	1	gliomas	glioma	NOUN
brainmatters-996	3	2	originate	originate	VERB
brainmatters-996	3	3	from	from	ADP
brainmatters-996	3	4	genetic	genetic	ADJ
brainmatters-996	3	5	mutations	mutation	NOUN
brainmatters-996	3	6	in	in	ADP
brainmatters-996	3	7	glial	glial	ADJ
brainmatters-996	3	8	cells	cell	NOUN
brainmatters-996	3	9	,	,	PUNCT
brainmatters-996	3	10	which	which	PRON
brainmatters-996	3	11	provide	provide	VERB
brainmatters-996	3	12	physical	physical	ADJ
brainmatters-996	3	13	and	and	CCONJ
brainmatters-996	3	14	chemical	chemical	NOUN
brainmatters-996	3	15	support	support	NOUN
brainmatters-996	3	16	for	for	ADP
brainmatters-996	3	17	neurons	neuron	NOUN
brainmatters-996	3	18	(	(	PUNCT
brainmatters-996	3	19	nord	nord	PROPN
brainmatters-996	3	20	,	,	PUNCT
brainmatters-996	3	21	n.d	n.d	PROPN
brainmatters-996	3	22	.	.	PROPN
brainmatters-996	3	23	)	)	PUNCT
brainmatters-996	3	24	.	.	PUNCT
brainmatters-996	4	1	according	accord	VERB
brainmatters-996	4	2	to	to	ADP
brainmatters-996	4	3	the	the	DET
brainmatters-996	4	4	world	world	PROPN
brainmatters-996	4	5	health	health	PROPN
brainmatters-996	4	6	organization	organization	NOUN
brainmatters-996	4	7	,	,	PUNCT
brainmatters-996	4	8	gliomas	glioma	NOUN
brainmatters-996	4	9	are	be	AUX
brainmatters-996	4	10	divided	divide	VERB
brainmatters-996	4	11	into	into	ADP
brainmatters-996	4	12	grades	grade	NOUN
brainmatters-996	4	13	i	i	PRON
brainmatters-996	4	14	-	-	PUNCT
brainmatters-996	4	15	iv	iv	PROPN
brainmatters-996	4	16	,	,	PUNCT
brainmatters-996	4	17	depending	depend	VERB
brainmatters-996	4	18	on	on	ADP
brainmatters-996	4	19	the	the	DET
brainmatters-996	4	20	degree	degree	NOUN
brainmatters-996	4	21	of	of	ADP
brainmatters-996	4	22	malignancy	malignancy	NOUN
brainmatters-996	4	23	.	.	PUNCT
brainmatters-996	5	1	grade	grade	NOUN
brainmatters-996	5	2	i	i	PRON
brainmatters-996	5	3	gliomas	glioma	NOUN
brainmatters-996	5	4	are	be	AUX
brainmatters-996	5	5	typically	typically	ADV
brainmatters-996	5	6	benign	benign	ADJ
brainmatters-996	5	7	and	and	CCONJ
brainmatters-996	5	8	slow	slow	ADV
brainmatters-996	5	9	-	-	PUNCT
brainmatters-996	5	10	growing	grow	VERB
brainmatters-996	5	11	,	,	PUNCT
brainmatters-996	5	12	often	often	ADV
brainmatters-996	5	13	associated	associate	VERB
brainmatters-996	5	14	with	with	ADP
brainmatters-996	5	15	mutations	mutation	NOUN
brainmatters-996	5	16	in	in	ADP
brainmatters-996	5	17	the	the	DET
brainmatters-996	5	18	neurofibromin	neurofibromin	NOUN
brainmatters-996	6	1	i	i	PRON
brainmatters-996	6	2	(	(	PUNCT
brainmatters-996	6	3	nf	nf	PROPN
brainmatters-996	6	4	i	i	NOUN
brainmatters-996	6	5	)	)	PUNCT
brainmatters-996	6	6	gene	gene	NOUN
brainmatters-996	6	7	,	,	PUNCT
brainmatters-996	6	8	responsible	responsible	ADJ
brainmatters-996	6	9	for	for	ADP
brainmatters-996	6	10	growth	growth	NOUN
brainmatters-996	6	11	regulation	regulation	NOUN
brainmatters-996	6	12	(	(	PUNCT
brainmatters-996	6	13	roswell	roswell	PROPN
brainmatters-996	6	14	park	park	PROPN
brainmatters-996	6	15	comprehensive	comprehensive	PROPN
brainmatters-996	6	16	cancer	cancer	NOUN
brainmatters-996	6	17	center	center	NOUN
brainmatters-996	6	18	,	,	PUNCT
brainmatters-996	6	19	n.d	n.d	PROPN
brainmatters-996	6	20	.	.	PROPN
brainmatters-996	6	21	)	)	PUNCT
brainmatters-996	6	22	.	.	PUNCT
brainmatters-996	7	1	grade	grade	NOUN
brainmatters-996	7	2	ii	ii	PROPN
brainmatters-996	7	3	and	and	CCONJ
brainmatters-996	7	4	grade	grade	NOUN
brainmatters-996	7	5	iii	iii	NUM
brainmatters-996	7	6	gliomas	glioma	NOUN
brainmatters-996	7	7	,	,	PUNCT
brainmatters-996	7	8	characterized	characterize	VERB
brainmatters-996	7	9	by	by	ADP
brainmatters-996	7	10	rapid	rapid	ADJ
brainmatters-996	7	11	growth	growth	NOUN
brainmatters-996	7	12	,	,	PUNCT
brainmatters-996	7	13	most	most	ADV
brainmatters-996	7	14	often	often	ADV
brainmatters-996	7	15	arise	arise	VERB
brainmatters-996	7	16	from	from	ADP
brainmatters-996	7	17	mutations	mutation	NOUN
brainmatters-996	7	18	in	in	ADP
brainmatters-996	7	19	the	the	DET
brainmatters-996	7	20	tp53	tp53	PROPN
brainmatters-996	7	21	gene	gene	NOUN
brainmatters-996	7	22	.	.	PUNCT
brainmatters-996	8	1	this	this	DET
brainmatters-996	8	2	gene	gene	NOUN
brainmatters-996	8	3	is	be	AUX
brainmatters-996	8	4	responsible	responsible	ADJ
brainmatters-996	8	5	for	for	ADP
brainmatters-996	8	6	the	the	DET
brainmatters-996	8	7	production	production	NOUN
brainmatters-996	8	8	of	of	ADP
brainmatters-996	8	9	a	a	DET
brainmatters-996	8	10	tumor	tumor	NOUN
brainmatters-996	8	11	suppressor	suppressor	NOUN
brainmatters-996	8	12	protein	protein	NOUN
brainmatters-996	8	13	.	.	PUNCT
brainmatters-996	9	1	grades	grade	NOUN
brainmatters-996	9	2	ii	ii	PROPN
brainmatters-996	9	3	and	and	CCONJ
brainmatters-996	9	4	iii	iii	NUM
brainmatters-996	9	5	are	be	AUX
brainmatters-996	9	6	rare	rare	ADJ
brainmatters-996	9	7	in	in	ADP
brainmatters-996	9	8	children	child	NOUN
brainmatters-996	9	9	,	,	PUNCT
brainmatters-996	9	10	but	but	CCONJ
brainmatters-996	9	11	commonly	commonly	ADV
brainmatters-996	9	12	manifest	manifest	VERB
brainmatters-996	9	13	in	in	ADP
brainmatters-996	9	14	young	young	ADJ
brainmatters-996	9	15	adults	adult	NOUN
brainmatters-996	9	16	.	.	PUNCT
brainmatters-996	10	1	grade	grade	NOUN
brainmatters-996	10	2	iv	iv	NUM
brainmatters-996	10	3	gliomas	glioma	NOUN
brainmatters-996	10	4	are	be	AUX
brainmatters-996	10	5	gbm	gbm	ADJ
brainmatters-996	10	6	,	,	PUNCT
brainmatters-996	10	7	and	and	CCONJ
brainmatters-996	10	8	are	be	AUX
brainmatters-996	10	9	the	the	DET
brainmatters-996	10	10	most	most	ADV
brainmatters-996	10	11	common	common	ADJ
brainmatters-996	10	12	and	and	CCONJ
brainmatters-996	10	13	malignant	malignant	ADJ
brainmatters-996	10	14	(	(	PUNCT
brainmatters-996	10	15	roswell	roswell	PROPN
brainmatters-996	10	16	park	park	PROPN
brainmatters-996	10	17	comprehensive	comprehensive	PROPN
brainmatters-996	10	18	cancer	cancer	NOUN
brainmatters-996	10	19	center	center	NOUN
brainmatters-996	10	20	,	,	PUNCT
brainmatters-996	10	21	n.d	n.d	PROPN
brainmatters-996	10	22	.	.	PROPN
brainmatters-996	10	23	)	)	PUNCT
brainmatters-996	10	24	.	.	PUNCT
brainmatters-996	11	1	gbm	gbm	PROPN
brainmatters-996	11	2	is	be	AUX
brainmatters-996	11	3	commonly	commonly	ADV
brainmatters-996	11	4	seen	see	VERB
brainmatters-996	11	5	in	in	ADP
brainmatters-996	11	6	patients	patient	NOUN
brainmatters-996	11	7	over	over	ADP
brainmatters-996	11	8	50	50	NUM
brainmatters-996	11	9	years	year	NOUN
brainmatters-996	11	10	of	of	ADP
brainmatters-996	11	11	age	age	NOUN
brainmatters-996	11	12	.	.	PUNCT
brainmatters-996	12	1	however	however	ADV
brainmatters-996	12	2	,	,	PUNCT
brainmatters-996	12	3	there	there	PRON
brainmatters-996	12	4	is	be	VERB
brainmatters-996	12	5	growing	grow	VERB
brainmatters-996	12	6	evidence	evidence	NOUN
brainmatters-996	12	7	that	that	SCONJ
brainmatters-996	12	8	gbm	gbm	PROPN
brainmatters-996	12	9	can	can	AUX
brainmatters-996	12	10	also	also	ADV
brainmatters-996	12	11	develop	develop	VERB
brainmatters-996	12	12	in	in	ADP
brainmatters-996	12	13	children	child	NOUN
brainmatters-996	12	14	,	,	PUNCT
brainmatters-996	12	15	adolescents	adolescent	NOUN
brainmatters-996	12	16	,	,	PUNCT
brainmatters-996	12	17	and	and	CCONJ
brainmatters-996	12	18	young	young	ADJ
brainmatters-996	12	19	adults	adult	NOUN
brainmatters-996	12	20	.	.	PUNCT
brainmatters-996	13	1	tumors	tumor	NOUN
brainmatters-996	13	2	found	find	VERB
brainmatters-996	13	3	in	in	ADP
brainmatters-996	13	4	younger	young	ADJ
brainmatters-996	13	5	individuals	individual	NOUN
brainmatters-996	13	6	,	,	PUNCT
brainmatters-996	13	7	though	though	ADV
brainmatters-996	13	8	,	,	PUNCT
brainmatters-996	13	9	are	be	AUX
brainmatters-996	13	10	genetically	genetically	ADV
brainmatters-996	13	11	unique	unique	ADJ
brainmatters-996	13	12	from	from	ADP
brainmatters-996	13	13	those	those	PRON
brainmatters-996	13	14	found	find	VERB
brainmatters-996	13	15	in	in	ADP
brainmatters-996	13	16	older	old	ADJ
brainmatters-996	13	17	adults	adult	NOUN
brainmatters-996	13	18	(	(	PUNCT
brainmatters-996	13	19	mdpi	mdpi	X
brainmatters-996	13	20	,	,	PUNCT
brainmatters-996	13	21	n.d	n.d	PROPN
brainmatters-996	13	22	.	.	PROPN
brainmatters-996	13	23	)	)	PUNCT
brainmatters-996	13	24	.	.	PUNCT
brainmatters-996	14	1	gbm	gbm	PROPN
brainmatters-996	14	2	,	,	PUNCT
brainmatters-996	14	3	in	in	ADP
brainmatters-996	14	4	particular	particular	ADJ
brainmatters-996	14	5	,	,	PUNCT
brainmatters-996	14	6	develops	develop	VERB
brainmatters-996	14	7	from	from	ADP
brainmatters-996	14	8	astrocytes	astrocyte	NOUN
brainmatters-996	14	9	(	(	PUNCT
brainmatters-996	14	10	fig	fig	NOUN
brainmatters-996	14	11	.	.	NOUN
brainmatters-996	14	12	1	1	NUM
brainmatters-996	14	13	)	)	PUNCT
brainmatters-996	14	14	.	.	PUNCT
brainmatters-996	15	1	glioblastoma	glioblastoma	NOUN
brainmatters-996	15	2	multiforme	multiforme	NOUN
brainmatters-996	15	3	:	:	PUNCT
brainmatters-996	15	4	challenges	challenge	NOUN
brainmatters-996	15	5	and	and	CCONJ
brainmatters-996	15	6	advancements	advancement	NOUN
brainmatters-996	15	7	in	in	ADP
brainmatters-996	15	8	treatment	treatment	NOUN
brainmatters-996	15	9	casey	casey	NOUN
brainmatters-996	15	10	meskovich	meskovich	PRON
brainmatters-996	15	11	abstract	abstract	ADJ
brainmatters-996	15	12	glioblastoma	glioblastoma	NOUN
brainmatters-996	15	13	multiforme	multiforme	NOUN
brainmatters-996	15	14	(	(	PUNCT
brainmatters-996	15	15	gbm	gbm	PROPN
brainmatters-996	15	16	)	)	PUNCT
brainmatters-996	15	17	is	be	AUX
brainmatters-996	15	18	a	a	DET
brainmatters-996	15	19	tumor	tumor	NOUN
brainmatters-996	15	20	that	that	PRON
brainmatters-996	15	21	is	be	AUX
brainmatters-996	15	22	initiated	initiate	VERB
brainmatters-996	15	23	in	in	ADP
brainmatters-996	15	24	glial	glial	ADJ
brainmatters-996	15	25	cells	cell	NOUN
brainmatters-996	15	26	,	,	PUNCT
brainmatters-996	15	27	usually	usually	ADV
brainmatters-996	15	28	astrocytes	astrocyte	NOUN
brainmatters-996	15	29	.	.	PUNCT
brainmatters-996	16	1	gbm	gbm	PROPN
brainmatters-996	16	2	presents	present	VERB
brainmatters-996	16	3	difficulties	difficulty	NOUN
brainmatters-996	16	4	in	in	ADP
brainmatters-996	16	5	treatment	treatment	NOUN
brainmatters-996	16	6	due	due	ADP
brainmatters-996	16	7	to	to	ADP
brainmatters-996	16	8	the	the	DET
brainmatters-996	16	9	delocalization	delocalization	NOUN
brainmatters-996	16	10	of	of	ADP
brainmatters-996	16	11	tumor	tumor	NOUN
brainmatters-996	16	12	cells	cell	NOUN
brainmatters-996	16	13	,	,	PUNCT
brainmatters-996	16	14	inherent	inherent	ADJ
brainmatters-996	16	15	resistance	resistance	NOUN
brainmatters-996	16	16	to	to	ADP
brainmatters-996	16	17	most	most	ADJ
brainmatters-996	16	18	cancer	cancer	NOUN
brainmatters-996	16	19	drugs	drug	NOUN
brainmatters-996	16	20	,	,	PUNCT
brainmatters-996	16	21	and	and	CCONJ
brainmatters-996	16	22	the	the	DET
brainmatters-996	16	23	limited	limited	ADJ
brainmatters-996	16	24	capacity	capacity	NOUN
brainmatters-996	16	25	of	of	ADP
brainmatters-996	16	26	the	the	DET
brainmatters-996	16	27	brain	brain	NOUN
brainmatters-996	16	28	to	to	PART
brainmatters-996	16	29	repair	repair	VERB
brainmatters-996	16	30	itself	itself	PRON
brainmatters-996	16	31	.	.	PUNCT
brainmatters-996	17	1	although	although	SCONJ
brainmatters-996	17	2	most	most	ADJ
brainmatters-996	17	3	cancers	cancer	NOUN
brainmatters-996	17	4	have	have	AUX
brainmatters-996	17	5	demonstrated	demonstrate	VERB
brainmatters-996	17	6	an	an	DET
brainmatters-996	17	7	increase	increase	NOUN
brainmatters-996	17	8	in	in	ADP
brainmatters-996	17	9	treatment	treatment	NOUN
brainmatters-996	17	10	efficacy	efficacy	NOUN
brainmatters-996	17	11	associated	associate	VERB
brainmatters-996	17	12	with	with	ADP
brainmatters-996	17	13	recent	recent	ADJ
brainmatters-996	17	14	technologies	technology	NOUN
brainmatters-996	17	15	,	,	PUNCT
brainmatters-996	17	16	the	the	DET
brainmatters-996	17	17	recovery	recovery	NOUN
brainmatters-996	17	18	rate	rate	NOUN
brainmatters-996	17	19	of	of	ADP
brainmatters-996	17	20	gbm	gbm	PROPN
brainmatters-996	17	21	has	have	AUX
brainmatters-996	17	22	remained	remain	VERB
brainmatters-996	17	23	stagnant	stagnant	ADJ
brainmatters-996	17	24	over	over	ADP
brainmatters-996	17	25	the	the	DET
brainmatters-996	17	26	years	year	NOUN
brainmatters-996	17	27	.	.	PUNCT
brainmatters-996	18	1	recent	recent	ADJ
brainmatters-996	18	2	research	research	NOUN
brainmatters-996	18	3	,	,	PUNCT
brainmatters-996	18	4	focusing	focus	VERB
brainmatters-996	18	5	on	on	ADP
brainmatters-996	18	6	the	the	DET
brainmatters-996	18	7	immune	immune	ADJ
brainmatters-996	18	8	response	response	NOUN
brainmatters-996	18	9	of	of	ADP
brainmatters-996	18	10	the	the	DET
brainmatters-996	18	11	brain	brain	NOUN
brainmatters-996	18	12	,	,	PUNCT
brainmatters-996	18	13	has	have	AUX
brainmatters-996	18	14	sparked	spark	VERB
brainmatters-996	18	15	hope	hope	NOUN
brainmatters-996	18	16	for	for	ADP
brainmatters-996	18	17	better	well	ADJ
brainmatters-996	18	18	treatments	treatment	NOUN
brainmatters-996	18	19	.	.	PUNCT
brainmatters-996	19	1	this	this	DET
brainmatters-996	19	2	paper	paper	NOUN
brainmatters-996	19	3	discusses	discuss	VERB
brainmatters-996	19	4	why	why	SCONJ
brainmatters-996	19	5	previous	previous	ADJ
brainmatters-996	19	6	treatments	treatment	NOUN
brainmatters-996	19	7	have	have	AUX
brainmatters-996	19	8	been	be	AUX
brainmatters-996	19	9	ineffective	ineffective	ADJ
brainmatters-996	19	10	and	and	CCONJ
brainmatters-996	19	11	describes	describe	VERB
brainmatters-996	19	12	the	the	DET
brainmatters-996	19	13	recent	recent	ADJ
brainmatters-996	19	14	advancements	advancement	NOUN
brainmatters-996	19	15	in	in	ADP
brainmatters-996	19	16	treatment	treatment	NOUN
brainmatters-996	19	17	.	.	PUNCT
brainmatters-996	20	1	introduction	introduction	NOUN
brainmatters-996	20	2	one	one	NUM
brainmatters-996	20	3	afternoon	afternoon	NOUN
brainmatters-996	20	4	in	in	ADP
brainmatters-996	20	5	september	september	PROPN
brainmatters-996	20	6	of	of	ADP
brainmatters-996	20	7	2018	2018	NUM
brainmatters-996	20	8	,	,	PUNCT
brainmatters-996	20	9	henry	henry	PROPN
brainmatters-996	20	10	leonard	leonard	PROPN
brainmatters-996	20	11	’s	’s	PART
brainmatters-996	20	12	office	office	NOUN
brainmatters-996	20	13	hummed	hum	VERB
brainmatters-996	20	14	with	with	ADP
brainmatters-996	20	15	the	the	DET
brainmatters-996	20	16	clacking	clacking	NOUN
brainmatters-996	20	17	of	of	ADP
brainmatters-996	20	18	computer	computer	NOUN
brainmatters-996	20	19	keys	key	NOUN
brainmatters-996	20	20	and	and	CCONJ
brainmatters-996	20	21	quiet	quiet	ADJ
brainmatters-996	20	22	chatter	chatter	NOUN
brainmatters-996	20	23	between	between	ADP
brainmatters-996	20	24	coworkers	coworker	NOUN
brainmatters-996	20	25	–	–	PUNCT
brainmatters-996	20	26	and	and	CCONJ
brainmatters-996	20	27	,	,	PUNCT
brainmatters-996	20	28	henry	henry	PROPN
brainmatters-996	20	29	’s	’s	PART
brainmatters-996	20	30	snoring	snoring	NOUN
brainmatters-996	20	31	.	.	PUNCT
brainmatters-996	21	1	he	he	PRON
brainmatters-996	21	2	had	have	AUX
brainmatters-996	21	3	been	be	AUX
brainmatters-996	21	4	asleep	asleep	ADJ
brainmatters-996	21	5	at	at	ADP
brainmatters-996	21	6	his	his	PRON
brainmatters-996	21	7	desk	desk	NOUN
brainmatters-996	21	8	for	for	ADP
brainmatters-996	21	9	approximately	approximately	ADV
brainmatters-996	21	10	fifteen	fifteen	NUM
brainmatters-996	21	11	minutes	minute	NOUN
brainmatters-996	21	12	before	before	SCONJ
brainmatters-996	21	13	a	a	DET
brainmatters-996	21	14	concerned	concerned	ADJ
brainmatters-996	21	15	colleague	colleague	NOUN
brainmatters-996	21	16	shook	shake	VERB
brainmatters-996	21	17	him	he	PRON
brainmatters-996	21	18	awake	awake	ADJ
brainmatters-996	21	19	.	.	PUNCT
brainmatters-996	22	1	taking	take	VERB
brainmatters-996	22	2	a	a	DET
brainmatters-996	22	3	sip	sip	NOUN
brainmatters-996	22	4	of	of	ADP
brainmatters-996	22	5	his	his	PRON
brainmatters-996	22	6	coffee	coffee	NOUN
brainmatters-996	22	7	,	,	PUNCT
brainmatters-996	22	8	henry	henry	PROPN
brainmatters-996	22	9	dismissed	dismiss	VERB
brainmatters-996	22	10	his	his	PRON
brainmatters-996	22	11	lethargy	lethargy	NOUN
brainmatters-996	22	12	as	as	ADP
brainmatters-996	22	13	a	a	DET
brainmatters-996	22	14	symptom	symptom	NOUN
brainmatters-996	22	15	of	of	ADP
brainmatters-996	22	16	aging	aging	NOUN
brainmatters-996	22	17	;	;	PUNCT
brainmatters-996	22	18	he	he	PRON
brainmatters-996	22	19	had	have	AUX
brainmatters-996	22	20	always	always	ADV
brainmatters-996	22	21	been	be	AUX
brainmatters-996	22	22	healthy	healthy	ADJ
brainmatters-996	22	23	and	and	CCONJ
brainmatters-996	22	24	did	do	AUX
brainmatters-996	22	25	n’t	not	PART
brainmatters-996	22	26	see	see	VERB
brainmatters-996	22	27	any	any	DET
brainmatters-996	22	28	other	other	ADJ
brainmatters-996	22	29	explanation	explanation	NOUN
brainmatters-996	22	30	.	.	PUNCT
brainmatters-996	23	1	he	he	PRON
brainmatters-996	23	2	squinted	squint	VERB
brainmatters-996	23	3	at	at	ADP
brainmatters-996	23	4	his	his	PRON
brainmatters-996	23	5	computer	computer	NOUN
brainmatters-996	23	6	,	,	PUNCT
brainmatters-996	23	7	unsure	unsure	ADJ
brainmatters-996	23	8	of	of	ADP
brainmatters-996	23	9	what	what	PRON
brainmatters-996	23	10	he	he	PRON
brainmatters-996	23	11	’d	’d	VERB
brainmatters-996	23	12	been	be	AUX
brainmatters-996	23	13	working	work	VERB
brainmatters-996	23	14	on	on	ADP
brainmatters-996	23	15	before	before	ADP
brainmatters-996	23	16	falling	fall	VERB
brainmatters-996	23	17	asleep	asleep	ADJ
brainmatters-996	23	18	,	,	PUNCT
brainmatters-996	23	19	and	and	CCONJ
brainmatters-996	23	20	sighed	sigh	VERB
brainmatters-996	23	21	.	.	PUNCT
brainmatters-996	24	1	it	it	PRON
brainmatters-996	24	2	was	be	AUX
brainmatters-996	24	3	open	open	ADJ
brainmatters-996	24	4	to	to	ADP
brainmatters-996	24	5	an	an	DET
brainmatters-996	24	6	extensively	extensively	ADV
brainmatters-996	24	7	chaotic	chaotic	ADJ
brainmatters-996	24	8	weekly	weekly	ADJ
brainmatters-996	24	9	calendar	calendar	NOUN
brainmatters-996	24	10	.	.	PUNCT
brainmatters-996	25	1	typically	typically	ADV
brainmatters-996	25	2	,	,	PUNCT
brainmatters-996	25	3	henry	henry	PROPN
brainmatters-996	25	4	took	take	VERB
brainmatters-996	25	5	pride	pride	NOUN
brainmatters-996	25	6	in	in	ADP
brainmatters-996	25	7	being	be	AUX
brainmatters-996	25	8	well	well	ADV
brainmatters-996	25	9	-	-	PUNCT
brainmatters-996	25	10	organized	organize	VERB
brainmatters-996	25	11	,	,	PUNCT
brainmatters-996	25	12	but	but	CCONJ
brainmatters-996	25	13	had	have	AUX
brainmatters-996	25	14	recently	recently	ADV
brainmatters-996	25	15	found	find	VERB
brainmatters-996	25	16	himself	himself	PRON
brainmatters-996	25	17	struggling	struggle	VERB
brainmatters-996	25	18	to	to	PART
brainmatters-996	25	19	keep	keep	VERB
brainmatters-996	25	20	track	track	NOUN
brainmatters-996	25	21	of	of	ADP
brainmatters-996	25	22	projects	project	NOUN
brainmatters-996	25	23	.	.	PUNCT
brainmatters-996	26	1	a	a	DET
brainmatters-996	26	2	dull	dull	ADJ
brainmatters-996	26	3	ache	ache	NOUN
brainmatters-996	26	4	throbbed	throb	VERB
brainmatters-996	26	5	in	in	ADP
brainmatters-996	26	6	his	his	PRON
brainmatters-996	26	7	temples	temple	NOUN
brainmatters-996	26	8	as	as	SCONJ
brainmatters-996	26	9	henry	henry	PROPN
brainmatters-996	26	10	considered	consider	VERB
brainmatters-996	26	11	the	the	DET
brainmatters-996	26	12	work	work	NOUN
brainmatters-996	26	13	he	he	PRON
brainmatters-996	26	14	had	have	VERB
brainmatters-996	26	15	to	to	PART
brainmatters-996	26	16	finish	finish	VERB
brainmatters-996	26	17	that	that	DET
brainmatters-996	26	18	day	day	NOUN
brainmatters-996	26	19	.	.	PUNCT
brainmatters-996	27	1	preferring	prefer	VERB
brainmatters-996	27	2	to	to	PART
brainmatters-996	27	3	avoid	avoid	VERB
brainmatters-996	27	4	medication	medication	NOUN
brainmatters-996	27	5	when	when	SCONJ
brainmatters-996	27	6	possible	possible	ADJ
brainmatters-996	27	7	,	,	PUNCT
brainmatters-996	27	8	henry	henry	PROPN
brainmatters-996	27	9	ignored	ignore	VERB
brainmatters-996	27	10	the	the	DET
brainmatters-996	27	11	pain	pain	NOUN
brainmatters-996	27	12	.	.	PUNCT
brainmatters-996	28	1	as	as	SCONJ
brainmatters-996	28	2	the	the	DET
brainmatters-996	28	3	day	day	NOUN
brainmatters-996	28	4	progressed	progress	VERB
brainmatters-996	28	5	,	,	PUNCT
brainmatters-996	28	6	his	his	PRON
brainmatters-996	28	7	headache	headache	NOUN
brainmatters-996	28	8	developed	develop	VERB
brainmatters-996	28	9	into	into	ADP
brainmatters-996	28	10	nauseating	nauseate	VERB
brainmatters-996	28	11	pain	pain	NOUN
brainmatters-996	28	12	.	.	PUNCT
brainmatters-996	29	1	for	for	ADP
brainmatters-996	29	2	the	the	DET
brainmatters-996	29	3	first	first	ADJ
brainmatters-996	29	4	time	time	NOUN
brainmatters-996	29	5	in	in	ADP
brainmatters-996	29	6	fifteen	fifteen	NUM
brainmatters-996	29	7	years	year	NOUN
brainmatters-996	29	8	,	,	PUNCT
brainmatters-996	29	9	henry	henry	PROPN
brainmatters-996	29	10	swallowed	swallow	VERB
brainmatters-996	29	11	an	an	DET
brainmatters-996	29	12	aspirin	aspirin	NOUN
brainmatters-996	29	13	tablet	tablet	NOUN
brainmatters-996	29	14	.	.	PUNCT
brainmatters-996	30	1	the	the	DET
brainmatters-996	30	2	day	day	NOUN
brainmatters-996	30	3	trudged	trudge	VERB
brainmatters-996	30	4	on	on	ADP
brainmatters-996	30	5	,	,	PUNCT
brainmatters-996	30	6	and	and	CCONJ
brainmatters-996	30	7	henry	henry	PROPN
brainmatters-996	30	8	was	be	AUX
brainmatters-996	30	9	happy	happy	ADJ
brainmatters-996	30	10	to	to	PART
brainmatters-996	30	11	go	go	VERB
brainmatters-996	30	12	home	home	ADV
brainmatters-996	30	13	.	.	PUNCT
brainmatters-996	31	1	later	later	ADV
brainmatters-996	31	2	that	that	DET
brainmatters-996	31	3	night	night	NOUN
brainmatters-996	31	4	,	,	PUNCT
brainmatters-996	31	5	he	he	PRON
brainmatters-996	31	6	called	call	VERB
brainmatters-996	31	7	a	a	DET
brainmatters-996	31	8	close	close	ADJ
brainmatters-996	31	9	friend	friend	NOUN
brainmatters-996	31	10	to	to	PART
brainmatters-996	31	11	discuss	discuss	VERB
brainmatters-996	31	12	his	his	PRON
brainmatters-996	31	13	overtiredness	overtiredness	NOUN
brainmatters-996	31	14	,	,	PUNCT
brainmatters-996	31	15	but	but	CCONJ
brainmatters-996	31	16	was	be	AUX
brainmatters-996	31	17	met	meet	VERB
brainmatters-996	31	18	with	with	ADP
brainmatters-996	31	19	anger	anger	NOUN
brainmatters-996	31	20	rather	rather	ADV
brainmatters-996	31	21	than	than	ADP
brainmatters-996	31	22	sympathy	sympathy	NOUN
brainmatters-996	31	23	.	.	PUNCT
brainmatters-996	32	1	henry	henry	PROPN
brainmatters-996	32	2	was	be	AUX
brainmatters-996	32	3	shocked	shock	VERB
brainmatters-996	32	4	to	to	PART
brainmatters-996	32	5	learn	learn	VERB
brainmatters-996	32	6	that	that	SCONJ
brainmatters-996	32	7	he	he	PRON
brainmatters-996	32	8	had	have	AUX
brainmatters-996	32	9	spoken	speak	VERB
brainmatters-996	32	10	to	to	ADP
brainmatters-996	32	11	his	his	PRON
brainmatters-996	32	12	friend	friend	NOUN
brainmatters-996	32	13	the	the	DET
brainmatters-996	32	14	day	day	NOUN
brainmatters-996	32	15	before	before	ADV
brainmatters-996	32	16	,	,	PUNCT
brainmatters-996	32	17	and	and	CCONJ
brainmatters-996	32	18	had	have	AUX
brainmatters-996	32	19	been	be	AUX
brainmatters-996	32	20	aggressive	aggressive	ADJ
brainmatters-996	32	21	and	and	CCONJ
brainmatters-996	32	22	barely	barely	ADV
brainmatters-996	32	23	lucid	lucid	ADJ
brainmatters-996	32	24	.	.	PUNCT
brainmatters-996	33	1	he	he	PRON
brainmatters-996	33	2	had	have	VERB
brainmatters-996	33	3	no	no	DET
brainmatters-996	33	4	recollection	recollection	NOUN
brainmatters-996	33	5	of	of	ADP
brainmatters-996	33	6	this	this	DET
brainmatters-996	33	7	conversation	conversation	NOUN
brainmatters-996	33	8	,	,	PUNCT
brainmatters-996	33	9	and	and	CCONJ
brainmatters-996	33	10	apologized	apologize	VERB
brainmatters-996	33	11	profusely	profusely	ADV
brainmatters-996	33	12	.	.	PUNCT
brainmatters-996	34	1	later	later	ADV
brainmatters-996	34	2	that	that	DET
brainmatters-996	34	3	month	month	NOUN
brainmatters-996	34	4	,	,	PUNCT
brainmatters-996	34	5	henry	henry	PROPN
brainmatters-996	34	6	was	be	AUX
brainmatters-996	34	7	diagnosed	diagnose	VERB
brainmatters-996	34	8	with	with	ADP
brainmatters-996	34	9	glioblastoma	glioblastoma	NOUN
brainmatters-996	34	10	multiforme	multiforme	NOUN
brainmatters-996	34	11	,	,	PUNCT
brainmatters-996	34	12	an	an	DET
brainmatters-996	34	13	advanced	advanced	ADJ
brainmatters-996	34	14	form	form	NOUN
brainmatters-996	34	15	of	of	ADP
brainmatters-996	34	16	brain	brain	NOUN
brainmatters-996	34	17	cancer	cancer	NOUN
brainmatters-996	34	18	.	.	PUNCT
brainmatters-996	35	1	in	in	ADP
brainmatters-996	35	2	hindsight	hindsight	ADJ
brainmatters-996	35	3	,	,	PUNCT
brainmatters-996	35	4	these	these	PRON
brainmatters-996	35	5	were	be	AUX
brainmatters-996	35	6	his	his	PRON
brainmatters-996	35	7	first	first	ADJ
brainmatters-996	35	8	symptoms	symptom	NOUN
brainmatters-996	35	9	–	–	PUNCT
brainmatters-996	35	10	disorganization	disorganization	NOUN
brainmatters-996	35	11	,	,	PUNCT
brainmatters-996	35	12	headaches	headache	NOUN
brainmatters-996	35	13	,	,	PUNCT
brainmatters-996	35	14	memory	memory	NOUN
brainmatters-996	35	15	loss	loss	NOUN
brainmatters-996	35	16	,	,	PUNCT
brainmatters-996	35	17	and	and	CCONJ
brainmatters-996	35	18	inexplicable	inexplicable	ADJ
brainmatters-996	35	19	aggression	aggression	NOUN
brainmatters-996	35	20	.	.	PUNCT
brainmatters-996	36	1	it	it	PRON
brainmatters-996	36	2	was	be	AUX
brainmatters-996	36	3	a	a	DET
brainmatters-996	36	4	bleak	bleak	ADJ
brainmatters-996	36	5	prognosis	prognosis	NOUN
brainmatters-996	36	6	for	for	ADP
brainmatters-996	36	7	henry	henry	PROPN
brainmatters-996	36	8	;	;	PUNCT
brainmatters-996	36	9	very	very	ADV
brainmatters-996	36	10	little	little	ADJ
brainmatters-996	36	11	is	be	AUX
brainmatters-996	36	12	known	know	VERB
brainmatters-996	36	13	about	about	ADP
brainmatters-996	36	14	the	the	DET
brainmatters-996	36	15	causes	cause	NOUN
brainmatters-996	36	16	of	of	ADP
brainmatters-996	36	17	the	the	DET
brainmatters-996	36	18	disease	disease	NOUN
brainmatters-996	36	19	,	,	PUNCT
brainmatters-996	36	20	and	and	CCONJ
brainmatters-996	36	21	it	it	PRON
brainmatters-996	36	22	is	be	AUX
brainmatters-996	36	23	highly	highly	ADV
brainmatters-996	36	24	incurable	incurable	ADJ
brainmatters-996	36	25	.	.	PUNCT
brainmatters-996	37	1	despite	despite	SCONJ
brainmatters-996	37	2	being	be	AUX
brainmatters-996	37	3	the	the	DET
brainmatters-996	37	4	most	most	ADV
brainmatters-996	37	5	common	common	ADJ
brainmatters-996	37	6	type	type	NOUN
brainmatters-996	37	7	of	of	ADP
brainmatters-996	37	8	brain	brain	NOUN
brainmatters-996	37	9	tumor	tumor	NOUN
brainmatters-996	37	10	,	,	PUNCT
brainmatters-996	37	11	treatments	treatment	NOUN
brainmatters-996	37	12	for	for	ADP
brainmatters-996	37	13	gbm	gbm	PROPN
brainmatters-996	37	14	have	have	AUX
brainmatters-996	37	15	shown	show	VERB
brainmatters-996	37	16	minimal	minimal	ADJ
brainmatters-996	37	17	advancements	advancement	NOUN
brainmatters-996	37	18	compared	compare	VERB
brainmatters-996	37	19	to	to	ADP
brainmatters-996	37	20	treatments	treatment	NOUN
brainmatters-996	37	21	for	for	ADP
brainmatters-996	37	22	other	other	ADJ
brainmatters-996	37	23	types	type	NOUN
brainmatters-996	37	24	of	of	ADP
brainmatters-996	37	25	brain	brain	NOUN
brainmatters-996	37	26	cancer	cancer	NOUN
brainmatters-996	37	27	.	.	PUNCT
brainmatters-996	38	1	gbm	gbm	PROPN
brainmatters-996	38	2	carries	carry	VERB
brainmatters-996	38	3	an	an	DET
brainmatters-996	38	4	average	average	ADJ
brainmatters-996	38	5	fiveyear	fiveyear	NOUN
brainmatters-996	38	6	survival	survival	NOUN
brainmatters-996	38	7	rate	rate	NOUN
brainmatters-996	38	8	of	of	ADP
brainmatters-996	38	9	7.2	7.2	NUM
brainmatters-996	38	10	%	%	NOUN
brainmatters-996	38	11	,	,	PUNCT
brainmatters-996	38	12	significantly	significantly	ADV
brainmatters-996	38	13	lower	low	ADJ
brainmatters-996	38	14	than	than	ADP
brainmatters-996	38	15	the	the	DET
brainmatters-996	38	16	overall	overall	ADJ
brainmatters-996	38	17	five	five	NUM
brainmatters-996	38	18	-	-	PUNCT
brainmatters-996	38	19	year	year	NOUN
brainmatters-996	38	20	survival	survival	NOUN
brainmatters-996	38	21	rate	rate	NOUN
brainmatters-996	38	22	for	for	ADP
brainmatters-996	38	23	all	all	DET
brainmatters-996	38	24	types	type	NOUN
brainmatters-996	38	25	of	of	ADP
brainmatters-996	38	26	brain	brain	NOUN
brainmatters-996	38	27	cancer	cancer	NOUN
brainmatters-996	38	28	,	,	PUNCT
brainmatters-996	38	29	which	which	PRON
brainmatters-996	38	30	stands	stand	VERB
brainmatters-996	38	31	at	at	ADP
brainmatters-996	38	32	13	13	NUM
brainmatters-996	38	33	%	%	NOUN
brainmatters-996	38	34	(	(	PUNCT
brainmatters-996	38	35	nuffield	nuffield	PROPN
brainmatters-996	38	36	trust	trust	PROPN
brainmatters-996	38	37	,	,	PUNCT
brainmatters-996	38	38	2023	2023	NUM
brainmatters-996	38	39	)	)	PUNCT
brainmatters-996	38	40	.	.	PUNCT
brainmatters-996	39	1	figure	figure	NOUN
brainmatters-996	39	2	1	1	NUM
brainmatters-996	39	3	.	.	PUNCT
brainmatters-996	40	1	an	an	DET
brainmatters-996	40	2	astrocyte	astrocyte	NOUN
brainmatters-996	40	3	(	(	PUNCT
brainmatters-996	40	4	ferri	ferri	PROPN
brainmatters-996	40	5	,	,	PUNCT
brainmatters-996	40	6	2023	2023	NUM
brainmatters-996	40	7	)	)	PUNCT
brainmatters-996	40	8	.	.	PUNCT
brainmatters-996	41	1	brain	brain	PROPN
brainmatters-996	41	2	matters・volume	matters・volume	PROPN
brainmatters-996	41	3	vii	vii	PROPN
brainmatters-996	41	4	42	42	NUM
brainmatters-996	41	5	external	external	ADJ
brainmatters-996	41	6	conditions	condition	NOUN
brainmatters-996	41	7	(	(	PUNCT
brainmatters-996	41	8	like	like	INTJ
brainmatters-996	41	9	,	,	PUNCT
brainmatters-996	41	10	the	the	DET
brainmatters-996	41	11	presence	presence	NOUN
brainmatters-996	41	12	of	of	ADP
brainmatters-996	41	13	a	a	DET
brainmatters-996	41	14	new	new	ADJ
brainmatters-996	41	15	drug	drug	NOUN
brainmatters-996	41	16	in	in	ADP
brainmatters-996	41	17	the	the	DET
brainmatters-996	41	18	system	system	NOUN
brainmatters-996	41	19	)	)	PUNCT
brainmatters-996	41	20	.	.	PUNCT
brainmatters-996	42	1	the	the	DET
brainmatters-996	42	2	plasticity	plasticity	NOUN
brainmatters-996	42	3	(	(	PUNCT
brainmatters-996	42	4	ability	ability	NOUN
brainmatters-996	42	5	of	of	ADP
brainmatters-996	42	6	tumors	tumor	NOUN
brainmatters-996	42	7	to	to	PART
brainmatters-996	42	8	change	change	VERB
brainmatters-996	42	9	and	and	CCONJ
brainmatters-996	42	10	adapt	adapt	VERB
brainmatters-996	42	11	)	)	PUNCT
brainmatters-996	42	12	of	of	ADP
brainmatters-996	42	13	gbm	gbm	PROPN
brainmatters-996	42	14	,	,	PUNCT
brainmatters-996	42	15	combined	combine	VERB
brainmatters-996	42	16	with	with	ADP
brainmatters-996	42	17	the	the	DET
brainmatters-996	42	18	recurring	recur	VERB
brainmatters-996	42	19	nature	nature	NOUN
brainmatters-996	42	20	of	of	ADP
brainmatters-996	42	21	the	the	DET
brainmatters-996	42	22	tumors	tumor	NOUN
brainmatters-996	42	23	,	,	PUNCT
brainmatters-996	42	24	presents	present	VERB
brainmatters-996	42	25	a	a	DET
brainmatters-996	42	26	difficulty	difficulty	NOUN
brainmatters-996	42	27	in	in	ADP
brainmatters-996	42	28	treatment	treatment	NOUN
brainmatters-996	42	29	.	.	PUNCT
brainmatters-996	43	1	gbm	gbm	NOUN
brainmatters-996	43	2	is	be	AUX
brainmatters-996	43	3	most	most	ADV
brainmatters-996	43	4	commonly	commonly	ADV
brainmatters-996	43	5	treated	treat	VERB
brainmatters-996	43	6	with	with	ADP
brainmatters-996	43	7	surgery	surgery	NOUN
brainmatters-996	43	8	,	,	PUNCT
brainmatters-996	43	9	followed	follow	VERB
brainmatters-996	43	10	by	by	ADP
brainmatters-996	43	11	chemotherapy	chemotherapy	NOUN
brainmatters-996	43	12	.	.	PUNCT
brainmatters-996	44	1	radiation	radiation	NOUN
brainmatters-996	44	2	therapy	therapy	NOUN
brainmatters-996	44	3	is	be	AUX
brainmatters-996	44	4	also	also	ADV
brainmatters-996	44	5	used	use	VERB
brainmatters-996	44	6	,	,	PUNCT
brainmatters-996	44	7	often	often	ADV
brainmatters-996	44	8	after	after	ADP
brainmatters-996	44	9	a	a	DET
brainmatters-996	44	10	surgery	surgery	NOUN
brainmatters-996	44	11	to	to	PART
brainmatters-996	44	12	destroy	destroy	VERB
brainmatters-996	44	13	inaccessible	inaccessible	ADJ
brainmatters-996	44	14	cancerous	cancerous	ADJ
brainmatters-996	44	15	cells	cell	NOUN
brainmatters-996	44	16	.	.	PUNCT
brainmatters-996	45	1	each	each	PRON
brainmatters-996	45	2	of	of	ADP
brainmatters-996	45	3	these	these	DET
brainmatters-996	45	4	treatments	treatment	NOUN
brainmatters-996	45	5	are	be	AUX
brainmatters-996	45	6	uniquely	uniquely	ADV
brainmatters-996	45	7	unsuccessful	unsuccessful	ADJ
brainmatters-996	45	8	.	.	PUNCT
brainmatters-996	46	1	in	in	ADP
brainmatters-996	46	2	surgery	surgery	NOUN
brainmatters-996	46	3	,	,	PUNCT
brainmatters-996	46	4	for	for	ADP
brainmatters-996	46	5	example	example	NOUN
brainmatters-996	46	6	,	,	PUNCT
brainmatters-996	46	7	the	the	DET
brainmatters-996	46	8	delocalization	delocalization	NOUN
brainmatters-996	46	9	of	of	ADP
brainmatters-996	46	10	the	the	DET
brainmatters-996	46	11	tumor	tumor	NOUN
brainmatters-996	46	12	presents	present	VERB
brainmatters-996	46	13	a	a	DET
brainmatters-996	46	14	problem	problem	NOUN
brainmatters-996	46	15	–	–	PUNCT
brainmatters-996	46	16	gbm	gbm	NOUN
brainmatters-996	46	17	diffusely	diffusely	ADV
brainmatters-996	46	18	invades	invade	VERB
brainmatters-996	46	19	the	the	DET
brainmatters-996	46	20	brain	brain	NOUN
brainmatters-996	46	21	,	,	PUNCT
brainmatters-996	46	22	unlike	unlike	ADP
brainmatters-996	46	23	tumors	tumor	NOUN
brainmatters-996	46	24	in	in	ADP
brainmatters-996	46	25	other	other	ADJ
brainmatters-996	46	26	parts	part	NOUN
brainmatters-996	46	27	of	of	ADP
brainmatters-996	46	28	the	the	DET
brainmatters-996	46	29	body	body	NOUN
brainmatters-996	46	30	.	.	PUNCT
brainmatters-996	47	1	as	as	ADP
brainmatters-996	47	2	a	a	DET
brainmatters-996	47	3	result	result	NOUN
brainmatters-996	47	4	,	,	PUNCT
brainmatters-996	47	5	it	it	PRON
brainmatters-996	47	6	’s	’	VERB
brainmatters-996	47	7	difficult	difficult	ADJ
brainmatters-996	47	8	to	to	PART
brainmatters-996	47	9	remove	remove	VERB
brainmatters-996	47	10	the	the	DET
brainmatters-996	47	11	entire	entire	ADJ
brainmatters-996	47	12	tumor	tumor	NOUN
brainmatters-996	47	13	with	with	ADP
brainmatters-996	47	14	surgery	surgery	NOUN
brainmatters-996	47	15	(	(	PUNCT
brainmatters-996	47	16	ncbi	ncbi	NOUN
brainmatters-996	47	17	,	,	PUNCT
brainmatters-996	47	18	2020	2020	NUM
brainmatters-996	47	19	)	)	PUNCT
brainmatters-996	47	20	.	.	PUNCT
brainmatters-996	48	1	the	the	DET
brainmatters-996	48	2	presence	presence	NOUN
brainmatters-996	48	3	of	of	ADP
brainmatters-996	48	4	barriers	barrier	NOUN
brainmatters-996	48	5	presents	present	VERB
brainmatters-996	48	6	a	a	DET
brainmatters-996	48	7	challenge	challenge	NOUN
brainmatters-996	48	8	for	for	ADP
brainmatters-996	48	9	chemotherapy	chemotherapy	NOUN
brainmatters-996	48	10	.	.	PUNCT
brainmatters-996	49	1	both	both	CCONJ
brainmatters-996	49	2	the	the	DET
brainmatters-996	49	3	blood	blood	NOUN
brainmatters-996	49	4	-	-	PUNCT
brainmatters-996	49	5	brain	brain	NOUN
brainmatters-996	49	6	barrier	barrier	NOUN
brainmatters-996	49	7	(	(	PUNCT
brainmatters-996	49	8	bbb	bbb	PROPN
brainmatters-996	49	9	)	)	PUNCT
brainmatters-996	49	10	(	(	PUNCT
brainmatters-996	49	11	fig	fig	NOUN
brainmatters-996	49	12	.	.	PUNCT
brainmatters-996	49	13	2	2	NUM
brainmatters-996	49	14	)	)	PUNCT
brainmatters-996	49	15	and	and	CCONJ
brainmatters-996	49	16	the	the	DET
brainmatters-996	49	17	blood	blood	NOUN
brainmatters-996	49	18	-	-	PUNCT
brainmatters-996	49	19	tumor	tumor	NOUN
brainmatters-996	49	20	barrier	barrier	NOUN
brainmatters-996	49	21	(	(	PUNCT
brainmatters-996	49	22	btb	btb	NOUN
brainmatters-996	49	23	)	)	PUNCT
brainmatters-996	49	24	are	be	AUX
brainmatters-996	49	25	in	in	ADP
brainmatters-996	49	26	effect	effect	NOUN
brainmatters-996	49	27	when	when	SCONJ
brainmatters-996	49	28	treating	treat	VERB
brainmatters-996	49	29	gbm	gbm	NOUN
brainmatters-996	49	30	.	.	PUNCT
brainmatters-996	50	1	the	the	DET
brainmatters-996	50	2	blood	blood	NOUN
brainmatters-996	50	3	vessels	vessel	NOUN
brainmatters-996	50	4	that	that	PRON
brainmatters-996	50	5	vascularize	vascularize	VERB
brainmatters-996	50	6	in	in	ADP
brainmatters-996	50	7	the	the	DET
brainmatters-996	50	8	cns	cns	NOUN
brainmatters-996	50	9	are	be	AUX
brainmatters-996	50	10	highly	highly	ADV
brainmatters-996	50	11	selective	selective	ADJ
brainmatters-996	50	12	,	,	PUNCT
brainmatters-996	50	13	and	and	CCONJ
brainmatters-996	50	14	function	function	VERB
brainmatters-996	50	15	to	to	PART
brainmatters-996	50	16	regulate	regulate	VERB
brainmatters-996	50	17	the	the	DET
brainmatters-996	50	18	movement	movement	NOUN
brainmatters-996	50	19	of	of	ADP
brainmatters-996	50	20	molecules	molecule	NOUN
brainmatters-996	50	21	between	between	ADP
brainmatters-996	50	22	the	the	DET
brainmatters-996	50	23	blood	blood	NOUN
brainmatters-996	50	24	and	and	CCONJ
brainmatters-996	50	25	the	the	DET
brainmatters-996	50	26	brain	brain	NOUN
brainmatters-996	50	27	,	,	PUNCT
brainmatters-996	50	28	resulting	result	VERB
brainmatters-996	50	29	in	in	ADP
brainmatters-996	50	30	a	a	DET
brainmatters-996	50	31	membrane	membrane	NOUN
brainmatters-996	50	32	known	know	VERB
brainmatters-996	50	33	as	as	ADP
brainmatters-996	50	34	the	the	DET
brainmatters-996	50	35	blood	blood	NOUN
brainmatters-996	50	36	-	-	PUNCT
brainmatters-996	50	37	brain	brain	NOUN
brainmatters-996	50	38	barrier	barrier	NOUN
brainmatters-996	50	39	(	(	PUNCT
brainmatters-996	50	40	bbb	bbb	PROPN
brainmatters-996	50	41	)	)	PUNCT
brainmatters-996	50	42	(	(	PUNCT
brainmatters-996	50	43	ncbi	ncbi	NOUN
brainmatters-996	50	44	,	,	PUNCT
brainmatters-996	50	45	2020	2020	NUM
brainmatters-996	50	46	)	)	PUNCT
brainmatters-996	50	47	.	.	PUNCT
brainmatters-996	51	1	tumors	tumor	NOUN
brainmatters-996	51	2	are	be	AUX
brainmatters-996	51	3	known	know	VERB
brainmatters-996	51	4	to	to	PART
brainmatters-996	51	5	compromise	compromise	VERB
brainmatters-996	51	6	the	the	DET
brainmatters-996	51	7	bbb	bbb	PROPN
brainmatters-996	51	8	,	,	PUNCT
brainmatters-996	51	9	resulting	result	VERB
brainmatters-996	51	10	in	in	ADP
brainmatters-996	51	11	vasculature	vasculature	NOUN
brainmatters-996	51	12	called	call	VERB
brainmatters-996	51	13	the	the	DET
brainmatters-996	51	14	btb	btb	NOUN
brainmatters-996	51	15	.	.	PUNCT
brainmatters-996	52	1	the	the	DET
brainmatters-996	52	2	btb	btb	NOUN
brainmatters-996	52	3	is	be	AUX
brainmatters-996	52	4	characterized	characterize	VERB
brainmatters-996	52	5	by	by	ADP
brainmatters-996	52	6	a	a	DET
brainmatters-996	52	7	non	non	ADJ
brainmatters-996	52	8	-	-	ADJ
brainmatters-996	52	9	uniform	uniform	ADJ
brainmatters-996	52	10	permeability	permeability	NOUN
brainmatters-996	52	11	,	,	PUNCT
brainmatters-996	52	12	resulting	result	VERB
brainmatters-996	52	13	from	from	ADP
brainmatters-996	52	14	high	high	ADJ
brainmatters-996	52	15	heterogeneity	heterogeneity	NOUN
brainmatters-996	52	16	(	(	PUNCT
brainmatters-996	52	17	ncbi	ncbi	NOUN
brainmatters-996	52	18	,	,	PUNCT
brainmatters-996	52	19	2019	2019	NUM
brainmatters-996	52	20	)	)	PUNCT
brainmatters-996	52	21	,	,	PUNCT
brainmatters-996	52	22	and	and	CCONJ
brainmatters-996	52	23	forms	form	NOUN
brainmatters-996	52	24	during	during	ADP
brainmatters-996	52	25	the	the	DET
brainmatters-996	52	26	development	development	NOUN
brainmatters-996	52	27	of	of	ADP
brainmatters-996	52	28	metastasis	metastasis	NOUN
brainmatters-996	52	29	.	.	PUNCT
brainmatters-996	53	1	as	as	SCONJ
brainmatters-996	53	2	the	the	DET
brainmatters-996	53	3	tumor	tumor	NOUN
brainmatters-996	53	4	progresses	progress	VERB
brainmatters-996	53	5	,	,	PUNCT
brainmatters-996	53	6	vasculature	vasculature	NOUN
brainmatters-996	53	7	becomes	become	VERB
brainmatters-996	53	8	increasingly	increasingly	ADV
brainmatters-996	53	9	heterogeneous	heterogeneous	ADJ
brainmatters-996	53	10	.	.	PUNCT
brainmatters-996	54	1	normal	normal	ADJ
brainmatters-996	54	2	vasculature	vasculature	NOUN
brainmatters-996	54	3	is	be	AUX
brainmatters-996	54	4	neatly	neatly	ADV
brainmatters-996	54	5	arranged	arrange	VERB
brainmatters-996	54	6	in	in	ADP
brainmatters-996	54	7	a	a	DET
brainmatters-996	54	8	hierarchy	hierarchy	NOUN
brainmatters-996	54	9	of	of	ADP
brainmatters-996	54	10	evenly	evenly	ADV
brainmatters-996	54	11	spaced	space	VERB
brainmatters-996	54	12	and	and	CCONJ
brainmatters-996	54	13	welldifferentiated	welldifferentiate	VERB
brainmatters-996	54	14	arteries	artery	NOUN
brainmatters-996	54	15	,	,	PUNCT
brainmatters-996	54	16	capillaries	capillary	NOUN
brainmatters-996	54	17	,	,	PUNCT
brainmatters-996	54	18	venules	venule	NOUN
brainmatters-996	54	19	,	,	PUNCT
brainmatters-996	54	20	and	and	CCONJ
brainmatters-996	54	21	veins	vein	NOUN
brainmatters-996	54	22	.	.	PUNCT
brainmatters-996	55	1	vessels	vessel	NOUN
brainmatters-996	55	2	supplying	supply	VERB
brainmatters-996	55	3	tumors	tumor	NOUN
brainmatters-996	55	4	(	(	PUNCT
brainmatters-996	55	5	those	those	PRON
brainmatters-996	55	6	that	that	PRON
brainmatters-996	55	7	compromise	compromise	VERB
brainmatters-996	55	8	the	the	DET
brainmatters-996	55	9	btb	btb	NOUN
brainmatters-996	55	10	)	)	PUNCT
brainmatters-996	55	11	are	be	AUX
brainmatters-996	55	12	increasingly	increasingly	ADV
brainmatters-996	55	13	chaotic	chaotic	ADJ
brainmatters-996	55	14	,	,	PUNCT
brainmatters-996	55	15	often	often	ADV
brainmatters-996	55	16	following	follow	VERB
brainmatters-996	55	17	an	an	DET
brainmatters-996	55	18	irregular	irregular	ADJ
brainmatters-996	55	19	serpentine	serpentine	ADJ
brainmatters-996	55	20	path	path	NOUN
brainmatters-996	55	21	(	(	PUNCT
brainmatters-996	55	22	ncbi	ncbi	NOUN
brainmatters-996	55	23	,	,	PUNCT
brainmatters-996	55	24	2010	2010	NUM
brainmatters-996	55	25	)	)	PUNCT
brainmatters-996	55	26	.	.	PUNCT
brainmatters-996	56	1	selectively	selectively	ADV
brainmatters-996	56	2	permeable	permeable	ADJ
brainmatters-996	56	3	barriers	barrier	NOUN
brainmatters-996	56	4	have	have	AUX
brainmatters-996	56	5	been	be	AUX
brainmatters-996	56	6	shown	show	VERB
brainmatters-996	56	7	to	to	PART
brainmatters-996	56	8	reduce	reduce	VERB
brainmatters-996	56	9	the	the	DET
brainmatters-996	56	10	effectiveness	effectiveness	NOUN
brainmatters-996	56	11	of	of	ADP
brainmatters-996	56	12	cancer	cancer	NOUN
brainmatters-996	56	13	therapies	therapy	NOUN
brainmatters-996	56	14	for	for	ADP
brainmatters-996	56	15	gbm	gbm	NOUN
brainmatters-996	56	16	.	.	PUNCT
brainmatters-996	57	1	current	current	ADJ
brainmatters-996	57	2	therapeutics	therapeutic	NOUN
brainmatters-996	57	3	have	have	VERB
brainmatters-996	57	4	similar	similar	ADJ
brainmatters-996	57	5	sizes	size	NOUN
brainmatters-996	57	6	to	to	ADP
brainmatters-996	57	7	molecules	molecule	NOUN
brainmatters-996	57	8	that	that	PRON
brainmatters-996	57	9	will	will	AUX
brainmatters-996	57	10	not	not	PART
brainmatters-996	57	11	cross	cross	VERB
brainmatters-996	57	12	the	the	DET
brainmatters-996	57	13	bbb	bbb	NOUN
brainmatters-996	57	14	,	,	PUNCT
brainmatters-996	57	15	such	such	ADJ
brainmatters-996	57	16	as	as	ADP
brainmatters-996	57	17	recombinant	recombinant	ADJ
brainmatters-996	57	18	proteins	protein	NOUN
brainmatters-996	57	19	and	and	CCONJ
brainmatters-996	57	20	peptides	peptide	NOUN
brainmatters-996	57	21	,	,	PUNCT
brainmatters-996	57	22	antibodies	antibodie	VERB
brainmatters-996	57	23	,	,	PUNCT
brainmatters-996	57	24	and	and	CCONJ
brainmatters-996	57	25	viral	viral	ADJ
brainmatters-996	57	26	vectors	vector	NOUN
brainmatters-996	57	27	.	.	PUNCT
brainmatters-996	58	1	this	this	PRON
brainmatters-996	58	2	makes	make	VERB
brainmatters-996	58	3	it	it	PRON
brainmatters-996	58	4	difficult	difficult	ADJ
brainmatters-996	58	5	,	,	PUNCT
brainmatters-996	58	6	if	if	SCONJ
brainmatters-996	58	7	not	not	PART
brainmatters-996	58	8	impossible	impossible	ADJ
brainmatters-996	58	9	,	,	PUNCT
brainmatters-996	58	10	to	to	PART
brainmatters-996	58	11	find	find	VERB
brainmatters-996	58	12	therapeutics	therapeutic	NOUN
brainmatters-996	58	13	that	that	PRON
brainmatters-996	58	14	cross	cross	VERB
brainmatters-996	58	15	into	into	ADP
brainmatters-996	58	16	the	the	DET
brainmatters-996	58	17	brain	brain	NOUN
brainmatters-996	58	18	.	.	PUNCT
brainmatters-996	59	1	astrocytes	astrocyte	NOUN
brainmatters-996	59	2	have	have	VERB
brainmatters-996	59	3	a	a	DET
brainmatters-996	59	4	multitude	multitude	NOUN
brainmatters-996	59	5	of	of	ADP
brainmatters-996	59	6	functions	function	NOUN
brainmatters-996	59	7	within	within	ADP
brainmatters-996	59	8	the	the	DET
brainmatters-996	59	9	brain	brain	NOUN
brainmatters-996	59	10	,	,	PUNCT
brainmatters-996	59	11	ranging	range	VERB
brainmatters-996	59	12	from	from	ADP
brainmatters-996	59	13	clearing	clear	VERB
brainmatters-996	59	14	excess	excess	ADJ
brainmatters-996	59	15	neurotransmitters	neurotransmitter	NOUN
brainmatters-996	59	16	,	,	PUNCT
brainmatters-996	59	17	to	to	ADP
brainmatters-996	59	18	stabilizing	stabilize	VERB
brainmatters-996	59	19	and	and	CCONJ
brainmatters-996	59	20	regulating	regulate	VERB
brainmatters-996	59	21	the	the	DET
brainmatters-996	59	22	blood	blood	NOUN
brainmatters-996	59	23	-	-	PUNCT
brainmatters-996	59	24	brain	brain	NOUN
brainmatters-996	59	25	barrier	barrier	NOUN
brainmatters-996	59	26	(	(	PUNCT
brainmatters-996	59	27	bbb	bbb	PROPN
brainmatters-996	59	28	)	)	PUNCT
brainmatters-996	59	29	(	(	PUNCT
brainmatters-996	59	30	ncbi	ncbi	NOUN
brainmatters-996	59	31	,	,	PUNCT
brainmatters-996	59	32	2023	2023	NUM
brainmatters-996	59	33	)	)	PUNCT
brainmatters-996	59	34	.	.	PUNCT
brainmatters-996	60	1	astrocytes	astrocyte	NOUN
brainmatters-996	60	2	make	make	VERB
brainmatters-996	60	3	up	up	ADP
brainmatters-996	60	4	the	the	DET
brainmatters-996	60	5	majority	majority	NOUN
brainmatters-996	60	6	of	of	ADP
brainmatters-996	60	7	cells	cell	NOUN
brainmatters-996	60	8	in	in	ADP
brainmatters-996	60	9	the	the	DET
brainmatters-996	60	10	central	central	ADJ
brainmatters-996	60	11	nervous	nervous	ADJ
brainmatters-996	60	12	system	system	NOUN
brainmatters-996	60	13	;	;	PUNCT
brainmatters-996	60	14	this	this	PRON
brainmatters-996	60	15	is	be	AUX
brainmatters-996	60	16	unsurprising	unsurprising	ADJ
brainmatters-996	60	17	,	,	PUNCT
brainmatters-996	60	18	considering	consider	VERB
brainmatters-996	60	19	their	their	PRON
brainmatters-996	60	20	versatility	versatility	NOUN
brainmatters-996	60	21	.	.	PUNCT
brainmatters-996	61	1	astrocytes	astrocyte	NOUN
brainmatters-996	61	2	also	also	ADV
brainmatters-996	61	3	have	have	VERB
brainmatters-996	61	4	a	a	DET
brainmatters-996	61	5	wide	wide	ADJ
brainmatters-996	61	6	variety	variety	NOUN
brainmatters-996	61	7	of	of	ADP
brainmatters-996	61	8	locations	location	NOUN
brainmatters-996	61	9	within	within	ADP
brainmatters-996	61	10	the	the	DET
brainmatters-996	61	11	central	central	ADJ
brainmatters-996	61	12	nervous	nervous	ADJ
brainmatters-996	61	13	system	system	NOUN
brainmatters-996	61	14	;	;	PUNCT
brainmatters-996	61	15	as	as	ADP
brainmatters-996	61	16	a	a	DET
brainmatters-996	61	17	result	result	NOUN
brainmatters-996	61	18	,	,	PUNCT
brainmatters-996	61	19	gbm	gbm	PROPN
brainmatters-996	61	20	can	can	AUX
brainmatters-996	61	21	start	start	VERB
brainmatters-996	61	22	anywhere	anywhere	ADV
brainmatters-996	61	23	in	in	ADP
brainmatters-996	61	24	the	the	DET
brainmatters-996	61	25	brain	brain	NOUN
brainmatters-996	61	26	.	.	PUNCT
brainmatters-996	62	1	however	however	ADV
brainmatters-996	62	2	,	,	PUNCT
brainmatters-996	62	3	it	it	PRON
brainmatters-996	62	4	most	most	ADV
brainmatters-996	62	5	commonly	commonly	ADV
brainmatters-996	62	6	forms	form	NOUN
brainmatters-996	62	7	in	in	ADP
brainmatters-996	62	8	the	the	DET
brainmatters-996	62	9	frontal	frontal	ADJ
brainmatters-996	62	10	and	and	CCONJ
brainmatters-996	62	11	temporal	temporal	ADJ
brainmatters-996	62	12	lobes	lobe	NOUN
brainmatters-996	62	13	,	,	PUNCT
brainmatters-996	62	14	which	which	PRON
brainmatters-996	62	15	play	play	VERB
brainmatters-996	62	16	roles	role	NOUN
brainmatters-996	62	17	in	in	ADP
brainmatters-996	62	18	speech	speech	NOUN
brainmatters-996	62	19	,	,	PUNCT
brainmatters-996	62	20	movement	movement	NOUN
brainmatters-996	62	21	,	,	PUNCT
brainmatters-996	62	22	behavior	behavior	NOUN
brainmatters-996	62	23	,	,	PUNCT
brainmatters-996	62	24	and	and	CCONJ
brainmatters-996	62	25	memory	memory	NOUN
brainmatters-996	62	26	.	.	PUNCT
brainmatters-996	63	1	resulting	result	VERB
brainmatters-996	63	2	symptoms	symptom	NOUN
brainmatters-996	63	3	,	,	PUNCT
brainmatters-996	63	4	then	then	ADV
brainmatters-996	63	5	,	,	PUNCT
brainmatters-996	63	6	coincide	coincide	VERB
brainmatters-996	63	7	with	with	ADP
brainmatters-996	63	8	these	these	DET
brainmatters-996	63	9	functions	function	NOUN
brainmatters-996	63	10	;	;	PUNCT
brainmatters-996	63	11	headaches	headache	NOUN
brainmatters-996	63	12	,	,	PUNCT
brainmatters-996	63	13	drowsiness	drowsiness	NOUN
brainmatters-996	63	14	,	,	PUNCT
brainmatters-996	63	15	personality	personality	NOUN
brainmatters-996	63	16	changes	change	NOUN
brainmatters-996	63	17	,	,	PUNCT
brainmatters-996	63	18	and	and	CCONJ
brainmatters-996	63	19	memory	memory	NOUN
brainmatters-996	63	20	loss	loss	NOUN
brainmatters-996	63	21	are	be	AUX
brainmatters-996	63	22	among	among	ADP
brainmatters-996	63	23	the	the	DET
brainmatters-996	63	24	most	most	ADV
brainmatters-996	63	25	common	common	ADJ
brainmatters-996	63	26	(	(	PUNCT
brainmatters-996	63	27	moffitt	moffitt	NOUN
brainmatters-996	63	28	cancer	cancer	NOUN
brainmatters-996	63	29	center	center	PROPN
brainmatters-996	63	30	,	,	PUNCT
brainmatters-996	63	31	n.d	n.d	PROPN
brainmatters-996	63	32	.	.	PROPN
brainmatters-996	63	33	)	)	PUNCT
brainmatters-996	63	34	.	.	PUNCT
brainmatters-996	64	1	the	the	DET
brainmatters-996	64	2	intensity	intensity	NOUN
brainmatters-996	64	3	of	of	ADP
brainmatters-996	64	4	these	these	DET
brainmatters-996	64	5	symptoms	symptom	NOUN
brainmatters-996	64	6	is	be	AUX
brainmatters-996	64	7	influenced	influence	VERB
brainmatters-996	64	8	by	by	ADP
brainmatters-996	64	9	genetic	genetic	ADJ
brainmatters-996	64	10	,	,	PUNCT
brainmatters-996	64	11	epigenetic	epigenetic	ADJ
brainmatters-996	64	12	,	,	PUNCT
brainmatters-996	64	13	and	and	CCONJ
brainmatters-996	64	14	microenvironmental	microenvironmental	ADJ
brainmatters-996	64	15	factors	factor	NOUN
brainmatters-996	64	16	.	.	PUNCT
brainmatters-996	65	1	uniquely	uniquely	ADV
brainmatters-996	65	2	,	,	PUNCT
brainmatters-996	65	3	family	family	NOUN
brainmatters-996	65	4	history	history	NOUN
brainmatters-996	65	5	is	be	AUX
brainmatters-996	65	6	not	not	PART
brainmatters-996	65	7	a	a	DET
brainmatters-996	65	8	factor	factor	NOUN
brainmatters-996	65	9	;	;	PUNCT
brainmatters-996	65	10	the	the	DET
brainmatters-996	65	11	majority	majority	NOUN
brainmatters-996	65	12	of	of	ADP
brainmatters-996	65	13	patients	patient	NOUN
brainmatters-996	65	14	have	have	VERB
brainmatters-996	65	15	no	no	DET
brainmatters-996	65	16	family	family	NOUN
brainmatters-996	65	17	history	history	NOUN
brainmatters-996	65	18	of	of	ADP
brainmatters-996	65	19	cancerous	cancerous	ADJ
brainmatters-996	65	20	brain	brain	NOUN
brainmatters-996	65	21	tumors	tumor	NOUN
brainmatters-996	65	22	.	.	PUNCT
brainmatters-996	66	1	there	there	PRON
brainmatters-996	66	2	is	be	VERB
brainmatters-996	66	3	,	,	PUNCT
brainmatters-996	66	4	however	however	ADV
brainmatters-996	66	5	,	,	PUNCT
brainmatters-996	66	6	a	a	DET
brainmatters-996	66	7	correlation	correlation	NOUN
brainmatters-996	66	8	between	between	ADP
brainmatters-996	66	9	gbm	gbm	NOUN
brainmatters-996	66	10	patients	patient	NOUN
brainmatters-996	66	11	and	and	CCONJ
brainmatters-996	66	12	the	the	DET
brainmatters-996	66	13	diagnosis	diagnosis	NOUN
brainmatters-996	66	14	of	of	ADP
brainmatters-996	66	15	close	close	ADJ
brainmatters-996	66	16	family	family	NOUN
brainmatters-996	66	17	members	member	NOUN
brainmatters-996	66	18	–	–	PUNCT
brainmatters-996	66	19	individuals	individual	NOUN
brainmatters-996	66	20	with	with	ADP
brainmatters-996	66	21	immediate	immediate	ADJ
brainmatters-996	66	22	relatives	relative	NOUN
brainmatters-996	66	23	afflicted	afflict	VERB
brainmatters-996	66	24	with	with	ADP
brainmatters-996	66	25	gbm	gbm	PROPN
brainmatters-996	66	26	are	be	AUX
brainmatters-996	66	27	twice	twice	ADV
brainmatters-996	66	28	as	as	ADV
brainmatters-996	66	29	likely	likely	ADJ
brainmatters-996	66	30	to	to	PART
brainmatters-996	66	31	develop	develop	VERB
brainmatters-996	66	32	the	the	DET
brainmatters-996	66	33	disease	disease	NOUN
brainmatters-996	66	34	.	.	PUNCT
brainmatters-996	67	1	the	the	DET
brainmatters-996	67	2	disease	disease	NOUN
brainmatters-996	67	3	is	be	AUX
brainmatters-996	67	4	linked	link	VERB
brainmatters-996	67	5	to	to	ADP
brainmatters-996	67	6	age	age	NOUN
brainmatters-996	67	7	,	,	PUNCT
brainmatters-996	67	8	with	with	ADP
brainmatters-996	67	9	a	a	DET
brainmatters-996	67	10	median	median	ADJ
brainmatters-996	67	11	age	age	NOUN
brainmatters-996	67	12	of	of	ADP
brainmatters-996	67	13	64	64	NUM
brainmatters-996	67	14	,	,	PUNCT
brainmatters-996	67	15	and	and	CCONJ
brainmatters-996	67	16	is	be	AUX
brainmatters-996	67	17	slightly	slightly	ADV
brainmatters-996	67	18	more	more	ADV
brainmatters-996	67	19	common	common	ADJ
brainmatters-996	67	20	in	in	ADP
brainmatters-996	67	21	men	man	NOUN
brainmatters-996	67	22	.	.	PUNCT
brainmatters-996	68	1	the	the	DET
brainmatters-996	68	2	only	only	ADJ
brainmatters-996	68	3	controllable	controllable	ADJ
brainmatters-996	68	4	risk	risk	NOUN
brainmatters-996	68	5	factor	factor	NOUN
brainmatters-996	68	6	for	for	ADP
brainmatters-996	68	7	gbm	gbm	PROPN
brainmatters-996	68	8	is	be	AUX
brainmatters-996	68	9	exposure	exposure	NOUN
brainmatters-996	68	10	to	to	ADP
brainmatters-996	68	11	ionizing	ionize	VERB
brainmatters-996	68	12	radiation	radiation	NOUN
brainmatters-996	68	13	therapy	therapy	NOUN
brainmatters-996	68	14	,	,	PUNCT
brainmatters-996	68	15	as	as	SCONJ
brainmatters-996	68	16	this	this	PRON
brainmatters-996	68	17	can	can	AUX
brainmatters-996	68	18	contribute	contribute	VERB
brainmatters-996	68	19	to	to	ADP
brainmatters-996	68	20	genetic	genetic	ADJ
brainmatters-996	68	21	mutations	mutation	NOUN
brainmatters-996	68	22	(	(	PUNCT
brainmatters-996	68	23	moffitt	moffitt	NOUN
brainmatters-996	68	24	cancer	cancer	NOUN
brainmatters-996	68	25	center	center	PROPN
brainmatters-996	68	26	,	,	PUNCT
brainmatters-996	68	27	n.d	n.d	PROPN
brainmatters-996	68	28	.	.	PROPN
brainmatters-996	68	29	)	)	PUNCT
brainmatters-996	68	30	.	.	PUNCT
brainmatters-996	69	1	in	in	ADP
brainmatters-996	69	2	most	most	ADJ
brainmatters-996	69	3	cases	case	NOUN
brainmatters-996	69	4	,	,	PUNCT
brainmatters-996	69	5	the	the	DET
brainmatters-996	69	6	exact	exact	ADJ
brainmatters-996	69	7	cause	cause	NOUN
brainmatters-996	69	8	of	of	ADP
brainmatters-996	69	9	gbm	gbm	NOUN
brainmatters-996	69	10	is	be	AUX
brainmatters-996	69	11	unknown	unknown	ADJ
brainmatters-996	69	12	.	.	PUNCT
brainmatters-996	70	1	however	however	ADV
brainmatters-996	70	2	,	,	PUNCT
brainmatters-996	70	3	there	there	PRON
brainmatters-996	70	4	are	be	VERB
brainmatters-996	70	5	a	a	DET
brainmatters-996	70	6	few	few	ADJ
brainmatters-996	70	7	similarities	similarity	NOUN
brainmatters-996	70	8	between	between	ADP
brainmatters-996	70	9	characteristics	characteristic	NOUN
brainmatters-996	70	10	of	of	ADP
brainmatters-996	70	11	patients	patient	NOUN
brainmatters-996	70	12	;	;	PUNCT
brainmatters-996	70	13	many	many	ADJ
brainmatters-996	70	14	harbor	harbor	VERB
brainmatters-996	70	15	mutations	mutation	NOUN
brainmatters-996	70	16	in	in	ADP
brainmatters-996	70	17	the	the	DET
brainmatters-996	70	18	idhi	idhi	NOUN
brainmatters-996	70	19	,	,	PUNCT
brainmatters-996	70	20	egfr	egfr	ADJ
brainmatters-996	70	21	,	,	PUNCT
brainmatters-996	70	22	pten	pten	VERB
brainmatters-996	70	23	,	,	PUNCT
brainmatters-996	70	24	tp53	tp53	PROPN
brainmatters-996	70	25	,	,	PUNCT
brainmatters-996	70	26	pi3k	pi3k	PROPN
brainmatters-996	70	27	,	,	PUNCT
brainmatters-996	70	28	and	and	CCONJ
brainmatters-996	70	29	tert	tert	NOUN
brainmatters-996	70	30	genes	gene	NOUN
brainmatters-996	70	31	,	,	PUNCT
brainmatters-996	70	32	which	which	PRON
brainmatters-996	70	33	are	be	AUX
brainmatters-996	70	34	coincidentally	coincidentally	ADV
brainmatters-996	70	35	among	among	ADP
brainmatters-996	70	36	the	the	DET
brainmatters-996	70	37	most	most	ADV
brainmatters-996	70	38	commonly	commonly	ADV
brainmatters-996	70	39	mutated	mutate	VERB
brainmatters-996	70	40	genes	gene	NOUN
brainmatters-996	70	41	in	in	ADP
brainmatters-996	70	42	human	human	ADJ
brainmatters-996	70	43	beings	being	NOUN
brainmatters-996	70	44	(	(	PUNCT
brainmatters-996	70	45	ncbi	ncbi	NOUN
brainmatters-996	70	46	,	,	PUNCT
brainmatters-996	70	47	2023	2023	NUM
brainmatters-996	70	48	)	)	PUNCT
brainmatters-996	70	49	.	.	PUNCT
brainmatters-996	71	1	although	although	SCONJ
brainmatters-996	71	2	functions	function	NOUN
brainmatters-996	71	3	of	of	ADP
brainmatters-996	71	4	these	these	DET
brainmatters-996	71	5	genes	gene	NOUN
brainmatters-996	71	6	are	be	AUX
brainmatters-996	71	7	generally	generally	ADV
brainmatters-996	71	8	different	different	ADJ
brainmatters-996	71	9	,	,	PUNCT
brainmatters-996	71	10	they	they	PRON
brainmatters-996	71	11	all	all	PRON
brainmatters-996	71	12	play	play	VERB
brainmatters-996	71	13	a	a	DET
brainmatters-996	71	14	role	role	NOUN
brainmatters-996	71	15	in	in	ADP
brainmatters-996	71	16	cellular	cellular	ADJ
brainmatters-996	71	17	pathway	pathway	NOUN
brainmatters-996	71	18	signaling	signal	VERB
brainmatters-996	71	19	.	.	PUNCT
brainmatters-996	72	1	in	in	ADP
brainmatters-996	72	2	rare	rare	ADJ
brainmatters-996	72	3	cases	case	NOUN
brainmatters-996	72	4	,	,	PUNCT
brainmatters-996	72	5	gbm	gbm	PROPN
brainmatters-996	72	6	can	can	AUX
brainmatters-996	72	7	be	be	AUX
brainmatters-996	72	8	linked	link	VERB
brainmatters-996	72	9	to	to	ADP
brainmatters-996	72	10	certain	certain	ADJ
brainmatters-996	72	11	genetic	genetic	ADJ
brainmatters-996	72	12	syndromes	syndrome	NOUN
brainmatters-996	72	13	,	,	PUNCT
brainmatters-996	72	14	such	such	ADJ
brainmatters-996	72	15	as	as	ADP
brainmatters-996	72	16	turcot	turcot	PROPN
brainmatters-996	72	17	syndrome	syndrome	NOUN
brainmatters-996	72	18	and	and	CCONJ
brainmatters-996	72	19	neurofibrosis	neurofibrosis	NOUN
brainmatters-996	72	20	type	type	NOUN
brainmatters-996	72	21	1	1	NUM
brainmatters-996	72	22	(	(	PUNCT
brainmatters-996	72	23	ncbi	ncbi	NOUN
brainmatters-996	72	24	,	,	PUNCT
brainmatters-996	72	25	2023	2023	NUM
brainmatters-996	72	26	)	)	PUNCT
brainmatters-996	72	27	.	.	PUNCT
brainmatters-996	73	1	current	current	ADJ
brainmatters-996	73	2	therapies	therapy	NOUN
brainmatters-996	73	3	and	and	CCONJ
brainmatters-996	73	4	their	their	PRON
brainmatters-996	73	5	success	success	NOUN
brainmatters-996	73	6	rates	rate	NOUN
brainmatters-996	73	7	for	for	ADP
brainmatters-996	73	8	gbm	gbm	PROPN
brainmatters-996	73	9	patients	patient	NOUN
brainmatters-996	73	10	,	,	PUNCT
brainmatters-996	73	11	options	option	NOUN
brainmatters-996	73	12	are	be	AUX
brainmatters-996	73	13	extremely	extremely	ADV
brainmatters-996	73	14	limited	limited	ADJ
brainmatters-996	73	15	,	,	PUNCT
brainmatters-996	73	16	as	as	SCONJ
brainmatters-996	73	17	gbm	gbm	PROPN
brainmatters-996	73	18	presents	present	VERB
brainmatters-996	73	19	distinct	distinct	ADJ
brainmatters-996	73	20	challenges	challenge	NOUN
brainmatters-996	73	21	.	.	PUNCT
brainmatters-996	74	1	localization	localization	NOUN
brainmatters-996	74	2	of	of	ADP
brainmatters-996	74	3	brain	brain	NOUN
brainmatters-996	74	4	tumors	tumor	NOUN
brainmatters-996	74	5	,	,	PUNCT
brainmatters-996	74	6	the	the	DET
brainmatters-996	74	7	presence	presence	NOUN
brainmatters-996	74	8	of	of	ADP
brainmatters-996	74	9	the	the	DET
brainmatters-996	74	10	bbb	bbb	PROPN
brainmatters-996	74	11	,	,	PUNCT
brainmatters-996	74	12	and	and	CCONJ
brainmatters-996	74	13	the	the	DET
brainmatters-996	74	14	limited	limited	ADJ
brainmatters-996	74	15	capacity	capacity	NOUN
brainmatters-996	74	16	of	of	ADP
brainmatters-996	74	17	the	the	DET
brainmatters-996	74	18	brain	brain	NOUN
brainmatters-996	74	19	to	to	PART
brainmatters-996	74	20	repair	repair	VERB
brainmatters-996	74	21	itself	itself	PRON
brainmatters-996	74	22	are	be	AUX
brainmatters-996	74	23	among	among	ADP
brainmatters-996	74	24	these	these	DET
brainmatters-996	74	25	challenges	challenge	NOUN
brainmatters-996	74	26	.	.	PUNCT
brainmatters-996	75	1	arguably	arguably	ADV
brainmatters-996	75	2	the	the	DET
brainmatters-996	75	3	most	most	ADJ
brainmatters-996	75	4	,	,	PUNCT
brainmatters-996	75	5	however	however	ADV
brainmatters-996	75	6	,	,	PUNCT
brainmatters-996	75	7	is	be	AUX
brainmatters-996	75	8	the	the	DET
brainmatters-996	75	9	inherent	inherent	ADJ
brainmatters-996	75	10	resistance	resistance	NOUN
brainmatters-996	75	11	to	to	ADP
brainmatters-996	75	12	conventional	conventional	ADJ
brainmatters-996	75	13	treatments	treatment	NOUN
brainmatters-996	75	14	(	(	PUNCT
brainmatters-996	75	15	american	american	PROPN
brainmatters-996	75	16	association	association	NOUN
brainmatters-996	75	17	of	of	ADP
brainmatters-996	75	18	neurological	neurological	ADJ
brainmatters-996	75	19	surgeons	surgeon	NOUN
brainmatters-996	75	20	,	,	PUNCT
brainmatters-996	75	21	n.d	n.d	PROPN
brainmatters-996	75	22	.	.	PROPN
brainmatters-996	75	23	)	)	PUNCT
brainmatters-996	75	24	.	.	PUNCT
brainmatters-996	76	1	gbm	gbm	PROPN
brainmatters-996	76	2	cells	cell	NOUN
brainmatters-996	76	3	have	have	VERB
brainmatters-996	76	4	stem	stem	NOUN
brainmatters-996	76	5	cell	cell	NOUN
brainmatters-996	76	6	properties	property	NOUN
brainmatters-996	76	7	.	.	PUNCT
brainmatters-996	77	1	they	they	PRON
brainmatters-996	77	2	’re	’re	VERB
brainmatters-996	77	3	able	able	ADJ
brainmatters-996	77	4	to	to	PART
brainmatters-996	77	5	selfrenew	selfrenew	VERB
brainmatters-996	77	6	and	and	CCONJ
brainmatters-996	77	7	differentiate	differentiate	VERB
brainmatters-996	77	8	into	into	ADP
brainmatters-996	77	9	different	different	ADJ
brainmatters-996	77	10	cell	cell	NOUN
brainmatters-996	77	11	types	type	NOUN
brainmatters-996	77	12	.	.	PUNCT
brainmatters-996	78	1	this	this	PRON
brainmatters-996	78	2	means	mean	VERB
brainmatters-996	78	3	that	that	SCONJ
brainmatters-996	78	4	tumors	tumor	NOUN
brainmatters-996	78	5	are	be	AUX
brainmatters-996	78	6	often	often	ADV
brainmatters-996	78	7	made	make	VERB
brainmatters-996	78	8	of	of	ADP
brainmatters-996	78	9	a	a	DET
brainmatters-996	78	10	number	number	NOUN
brainmatters-996	78	11	of	of	ADP
brainmatters-996	78	12	different	different	ADJ
brainmatters-996	78	13	types	type	NOUN
brainmatters-996	78	14	of	of	ADP
brainmatters-996	78	15	cells	cell	NOUN
brainmatters-996	78	16	,	,	PUNCT
brainmatters-996	78	17	a	a	DET
brainmatters-996	78	18	phenomenon	phenomenon	NOUN
brainmatters-996	78	19	referred	refer	VERB
brainmatters-996	78	20	to	to	ADP
brainmatters-996	78	21	as	as	ADP
brainmatters-996	78	22	heterogeneity	heterogeneity	NOUN
brainmatters-996	78	23	(	(	PUNCT
brainmatters-996	78	24	mdpi	mdpi	PROPN
brainmatters-996	78	25	,	,	PUNCT
brainmatters-996	78	26	n.d	n.d	PROPN
brainmatters-996	78	27	.	.	PROPN
brainmatters-996	78	28	)	)	PUNCT
brainmatters-996	78	29	.	.	PUNCT
brainmatters-996	79	1	additionally	additionally	ADV
brainmatters-996	79	2	,	,	PUNCT
brainmatters-996	79	3	cells	cell	NOUN
brainmatters-996	79	4	are	be	AUX
brainmatters-996	79	5	able	able	ADJ
brainmatters-996	79	6	to	to	PART
brainmatters-996	79	7	take	take	VERB
brainmatters-996	79	8	on	on	ADP
brainmatters-996	79	9	different	different	ADJ
brainmatters-996	79	10	functions	function	NOUN
brainmatters-996	79	11	or	or	CCONJ
brainmatters-996	79	12	roles	role	NOUN
brainmatters-996	79	13	within	within	ADP
brainmatters-996	79	14	any	any	DET
brainmatters-996	79	15	one	one	NUM
brainmatters-996	79	16	tumor	tumor	NOUN
brainmatters-996	79	17	,	,	PUNCT
brainmatters-996	79	18	and	and	CCONJ
brainmatters-996	79	19	change	change	VERB
brainmatters-996	79	20	these	these	DET
brainmatters-996	79	21	roles	role	NOUN
brainmatters-996	79	22	as	as	SCONJ
brainmatters-996	79	23	needed	need	VERB
brainmatters-996	79	24	.	.	PUNCT
brainmatters-996	80	1	cells	cell	NOUN
brainmatters-996	80	2	in	in	ADP
brainmatters-996	80	3	a	a	DET
brainmatters-996	80	4	tumor	tumor	NOUN
brainmatters-996	80	5	are	be	AUX
brainmatters-996	80	6	able	able	ADJ
brainmatters-996	80	7	to	to	PART
brainmatters-996	80	8	interact	interact	VERB
brainmatters-996	80	9	dynamically	dynamically	ADV
brainmatters-996	80	10	,	,	PUNCT
brainmatters-996	80	11	forming	form	VERB
brainmatters-996	80	12	a	a	DET
brainmatters-996	80	13	flexible	flexible	ADJ
brainmatters-996	80	14	tumor	tumor	NOUN
brainmatters-996	80	15	environment	environment	NOUN
brainmatters-996	80	16	(	(	PUNCT
brainmatters-996	80	17	mdpi	mdpi	PROPN
brainmatters-996	80	18	,	,	PUNCT
brainmatters-996	80	19	n.d	n.d	PROPN
brainmatters-996	80	20	.	.	PROPN
brainmatters-996	80	21	)	)	PUNCT
brainmatters-996	80	22	.	.	PUNCT
brainmatters-996	81	1	as	as	ADP
brainmatters-996	81	2	a	a	DET
brainmatters-996	81	3	result	result	NOUN
brainmatters-996	81	4	,	,	PUNCT
brainmatters-996	81	5	gbm	gbm	PROPN
brainmatters-996	81	6	is	be	AUX
brainmatters-996	81	7	able	able	ADJ
brainmatters-996	81	8	to	to	PART
brainmatters-996	81	9	adapt	adapt	VERB
brainmatters-996	81	10	quickly	quickly	ADV
brainmatters-996	81	11	and	and	CCONJ
brainmatters-996	81	12	effectively	effectively	ADV
brainmatters-996	81	13	to	to	PART
brainmatters-996	81	14	figure	figure	VERB
brainmatters-996	81	15	2	2	NUM
brainmatters-996	82	1	.	.	PUNCT
brainmatters-996	82	2	diagram	diagram	NOUN
brainmatters-996	82	3	of	of	ADP
brainmatters-996	82	4	the	the	DET
brainmatters-996	82	5	blood	blood	NOUN
brainmatters-996	82	6	brain	brain	NOUN
brainmatters-996	82	7	barrier	barrier	NOUN
brainmatters-996	82	8	(	(	PUNCT
brainmatters-996	82	9	parashar	parashar	NOUN
brainmatters-996	82	10	,	,	PUNCT
brainmatters-996	82	11	2012	2012	NUM
brainmatters-996	82	12	)	)	PUNCT
brainmatters-996	82	13	aimed	aim	VERB
brainmatters-996	82	14	to	to	PART
brainmatters-996	82	15	specifically	specifically	ADV
brainmatters-996	82	16	examine	examine	VERB
brainmatters-996	82	17	the	the	DET
brainmatters-996	82	18	effect	effect	NOUN
brainmatters-996	82	19	of	of	ADP
brainmatters-996	82	20	immune	immune	ADJ
brainmatters-996	82	21	checkpoint	checkpoint	NOUN
brainmatters-996	82	22	inhibitors	inhibitor	NOUN
brainmatters-996	82	23	to	to	PART
brainmatters-996	82	24	explain	explain	VERB
brainmatters-996	82	25	the	the	DET
brainmatters-996	82	26	higher	high	ADJ
brainmatters-996	82	27	response	response	NOUN
brainmatters-996	82	28	of	of	ADP
brainmatters-996	82	29	tumors	tumor	NOUN
brainmatters-996	82	30	originating	originate	VERB
brainmatters-996	82	31	outside	outside	ADV
brainmatters-996	82	32	of	of	ADP
brainmatters-996	82	33	the	the	DET
brainmatters-996	82	34	brain	brain	NOUN
brainmatters-996	82	35	to	to	ADP
brainmatters-996	82	36	immunotherapy	immunotherapy	NOUN
brainmatters-996	82	37	.	.	PUNCT
brainmatters-996	83	1	it	it	PRON
brainmatters-996	83	2	was	be	AUX
brainmatters-996	83	3	found	find	VERB
brainmatters-996	83	4	that	that	SCONJ
brainmatters-996	83	5	t	t	PROPN
brainmatters-996	83	6	cells	cell	NOUN
brainmatters-996	83	7	in	in	ADP
brainmatters-996	83	8	tumors	tumor	NOUN
brainmatters-996	83	9	that	that	PRON
brainmatters-996	83	10	did	do	AUX
brainmatters-996	83	11	not	not	PART
brainmatters-996	83	12	originate	originate	VERB
brainmatters-996	83	13	in	in	ADP
brainmatters-996	83	14	the	the	DET
brainmatters-996	83	15	brain	brain	NOUN
brainmatters-996	83	16	had	have	VERB
brainmatters-996	83	17	characteristics	characteristic	NOUN
brainmatters-996	83	18	that	that	PRON
brainmatters-996	83	19	implied	imply	VERB
brainmatters-996	83	20	tumors	tumor	NOUN
brainmatters-996	83	21	were	be	AUX
brainmatters-996	83	22	blocked	block	VERB
brainmatters-996	83	23	from	from	ADP
brainmatters-996	83	24	entering	enter	VERB
brainmatters-996	83	25	the	the	DET
brainmatters-996	83	26	brain	brain	NOUN
brainmatters-996	83	27	(	(	PUNCT
brainmatters-996	83	28	heady	heady	PROPN
brainmatters-996	83	29	&	&	CCONJ
brainmatters-996	83	30	sun	sun	PROPN
brainmatters-996	83	31	,	,	PUNCT
brainmatters-996	83	32	2023	2023	NUM
brainmatters-996	83	33	)	)	PUNCT
brainmatters-996	83	34	.	.	PUNCT
brainmatters-996	84	1	immunotherapy	immunotherapy	NOUN
brainmatters-996	84	2	led	lead	VERB
brainmatters-996	84	3	to	to	ADP
brainmatters-996	84	4	a	a	DET
brainmatters-996	84	5	significant	significant	ADJ
brainmatters-996	84	6	increase	increase	NOUN
brainmatters-996	84	7	in	in	ADP
brainmatters-996	84	8	t	t	NOUN
brainmatters-996	84	9	cell	cell	NOUN
brainmatters-996	84	10	lymphocytes	lymphocyte	VERB
brainmatters-996	84	11	in	in	ADP
brainmatters-996	84	12	brain	brain	NOUN
brainmatters-996	84	13	metastases	metastasis	NOUN
brainmatters-996	84	14	,	,	PUNCT
brainmatters-996	84	15	but	but	CCONJ
brainmatters-996	84	16	this	this	DET
brainmatters-996	84	17	increase	increase	NOUN
brainmatters-996	84	18	was	be	AUX
brainmatters-996	84	19	much	much	ADV
brainmatters-996	84	20	smaller	small	ADJ
brainmatters-996	84	21	in	in	ADP
brainmatters-996	84	22	patients	patient	NOUN
brainmatters-996	84	23	with	with	ADP
brainmatters-996	84	24	gbm	gbm	PROPN
brainmatters-996	84	25	(	(	PUNCT
brainmatters-996	84	26	heady	heady	PROPN
brainmatters-996	84	27	&	&	CCONJ
brainmatters-996	84	28	sun	sun	PROPN
brainmatters-996	84	29	,	,	PUNCT
brainmatters-996	84	30	2023	2023	NUM
brainmatters-996	84	31	)	)	PUNCT
brainmatters-996	84	32	.	.	PUNCT
brainmatters-996	85	1	this	this	DET
brainmatters-996	85	2	data	data	NOUN
brainmatters-996	85	3	suggests	suggest	VERB
brainmatters-996	85	4	that	that	SCONJ
brainmatters-996	85	5	the	the	DET
brainmatters-996	85	6	priming	prime	VERB
brainmatters-996	85	7	circuit	circuit	NOUN
brainmatters-996	85	8	is	be	AUX
brainmatters-996	85	9	not	not	PART
brainmatters-996	85	10	as	as	ADV
brainmatters-996	85	11	effective	effective	ADJ
brainmatters-996	85	12	in	in	ADP
brainmatters-996	85	13	gbm	gbm	NOUN
brainmatters-996	85	14	,	,	PUNCT
brainmatters-996	85	15	as	as	SCONJ
brainmatters-996	85	16	t	t	PROPN
brainmatters-996	85	17	cells	cell	NOUN
brainmatters-996	85	18	are	be	AUX
brainmatters-996	85	19	best	well	ADV
brainmatters-996	85	20	primed	prime	VERB
brainmatters-996	85	21	in	in	ADP
brainmatters-996	85	22	draining	drain	VERB
brainmatters-996	85	23	lymph	lymph	NOUN
brainmatters-996	85	24	nodes	node	NOUN
brainmatters-996	85	25	outside	outside	ADP
brainmatters-996	85	26	of	of	ADP
brainmatters-996	85	27	the	the	DET
brainmatters-996	85	28	brain	brain	NOUN
brainmatters-996	85	29	–	–	PUNCT
brainmatters-996	85	30	a	a	DET
brainmatters-996	85	31	process	process	NOUN
brainmatters-996	85	32	that	that	PRON
brainmatters-996	85	33	is	be	AUX
brainmatters-996	85	34	not	not	PART
brainmatters-996	85	35	possible	possible	ADJ
brainmatters-996	85	36	for	for	ADP
brainmatters-996	85	37	tumors	tumor	NOUN
brainmatters-996	85	38	originating	originate	VERB
brainmatters-996	85	39	inside	inside	ADV
brainmatters-996	85	40	of	of	ADP
brainmatters-996	85	41	the	the	DET
brainmatters-996	85	42	brain	brain	NOUN
brainmatters-996	85	43	.	.	PUNCT
brainmatters-996	86	1	in	in	ADP
brainmatters-996	86	2	the	the	DET
brainmatters-996	86	3	context	context	NOUN
brainmatters-996	86	4	of	of	ADP
brainmatters-996	86	5	tumors	tumor	NOUN
brainmatters-996	86	6	,	,	PUNCT
brainmatters-996	86	7	draining	drain	VERB
brainmatters-996	86	8	lymph	lymph	NOUN
brainmatters-996	86	9	nodes	node	NOUN
brainmatters-996	86	10	refer	refer	VERB
brainmatters-996	86	11	to	to	ADP
brainmatters-996	86	12	lymph	lymph	NOUN
brainmatters-996	86	13	nodes	node	NOUN
brainmatters-996	86	14	that	that	PRON
brainmatters-996	86	15	receive	receive	VERB
brainmatters-996	86	16	lymphatic	lymphatic	ADJ
brainmatters-996	86	17	drainage	drainage	NOUN
brainmatters-996	86	18	from	from	ADP
brainmatters-996	86	19	the	the	DET
brainmatters-996	86	20	area	area	NOUN
brainmatters-996	86	21	surrounding	surround	VERB
brainmatters-996	86	22	a	a	DET
brainmatters-996	86	23	tumor	tumor	NOUN
brainmatters-996	86	24	.	.	PUNCT
brainmatters-996	87	1	tumors	tumor	NOUN
brainmatters-996	87	2	often	often	ADV
brainmatters-996	87	3	stimulate	stimulate	VERB
brainmatters-996	87	4	the	the	DET
brainmatters-996	87	5	growth	growth	NOUN
brainmatters-996	87	6	of	of	ADP
brainmatters-996	87	7	new	new	ADJ
brainmatters-996	87	8	blood	blood	NOUN
brainmatters-996	87	9	vessels	vessel	NOUN
brainmatters-996	87	10	and	and	CCONJ
brainmatters-996	87	11	lymphatic	lymphatic	ADJ
brainmatters-996	87	12	vessels	vessel	NOUN
brainmatters-996	87	13	to	to	PART
brainmatters-996	87	14	support	support	VERB
brainmatters-996	87	15	their	their	PRON
brainmatters-996	87	16	growth	growth	NOUN
brainmatters-996	87	17	and	and	CCONJ
brainmatters-996	87	18	spread	spread	VERB
brainmatters-996	87	19	.	.	PUNCT
brainmatters-996	88	1	as	as	ADP
brainmatters-996	88	2	a	a	DET
brainmatters-996	88	3	result	result	NOUN
brainmatters-996	88	4	,	,	PUNCT
brainmatters-996	88	5	tumor	tumor	NOUN
brainmatters-996	88	6	cells	cell	NOUN
brainmatters-996	88	7	and	and	CCONJ
brainmatters-996	88	8	antigens	antigen	NOUN
brainmatters-996	88	9	can	can	AUX
brainmatters-996	88	10	enter	enter	VERB
brainmatters-996	88	11	the	the	DET
brainmatters-996	88	12	lymphatic	lymphatic	ADJ
brainmatters-996	88	13	system	system	NOUN
brainmatters-996	88	14	and	and	CCONJ
brainmatters-996	88	15	be	be	AUX
brainmatters-996	88	16	transported	transport	VERB
brainmatters-996	88	17	to	to	ADP
brainmatters-996	88	18	nearby	nearby	ADJ
brainmatters-996	88	19	lymph	lymph	NOUN
brainmatters-996	88	20	nodes	node	NOUN
brainmatters-996	88	21	(	(	PUNCT
brainmatters-996	88	22	koukourakis	koukouraki	NOUN
brainmatters-996	88	23	&	&	CCONJ
brainmatters-996	88	24	giatromanolaki	giatromanolaki	PROPN
brainmatters-996	88	25	,	,	PUNCT
brainmatters-996	88	26	2022	2022	NUM
brainmatters-996	88	27	)	)	PUNCT
brainmatters-996	88	28	.	.	PUNCT
brainmatters-996	89	1	from	from	ADP
brainmatters-996	89	2	these	these	DET
brainmatters-996	89	3	findings	finding	NOUN
brainmatters-996	89	4	,	,	PUNCT
brainmatters-996	89	5	researchers	researcher	NOUN
brainmatters-996	89	6	have	have	AUX
brainmatters-996	89	7	suggested	suggest	VERB
brainmatters-996	89	8	that	that	SCONJ
brainmatters-996	89	9	dendritic	dendritic	ADJ
brainmatters-996	89	10	cells	cell	NOUN
brainmatters-996	89	11	are	be	AUX
brainmatters-996	89	12	a	a	DET
brainmatters-996	89	13	potential	potential	ADJ
brainmatters-996	89	14	therapeutic	therapeutic	ADJ
brainmatters-996	89	15	strategy	strategy	NOUN
brainmatters-996	89	16	.	.	PUNCT
brainmatters-996	90	1	dendritic	dendritic	ADJ
brainmatters-996	90	2	cells	cell	NOUN
brainmatters-996	90	3	are	be	AUX
brainmatters-996	90	4	able	able	ADJ
brainmatters-996	90	5	to	to	PART
brainmatters-996	90	6	reach	reach	VERB
brainmatters-996	90	7	t	t	NOUN
brainmatters-996	90	8	cells	cell	NOUN
brainmatters-996	90	9	in	in	ADP
brainmatters-996	90	10	the	the	DET
brainmatters-996	90	11	brain	brain	NOUN
brainmatters-996	90	12	,	,	PUNCT
brainmatters-996	90	13	which	which	PRON
brainmatters-996	90	14	lymph	lymph	NOUN
brainmatters-996	90	15	nodes	node	NOUN
brainmatters-996	90	16	can	can	AUX
brainmatters-996	90	17	not	not	PART
brainmatters-996	90	18	do	do	VERB
brainmatters-996	90	19	.	.	PUNCT
brainmatters-996	91	1	this	this	DET
brainmatters-996	91	2	process	process	NOUN
brainmatters-996	91	3	would	would	AUX
brainmatters-996	91	4	include	include	VERB
brainmatters-996	91	5	generating	generate	VERB
brainmatters-996	91	6	dendritic	dendritic	ADJ
brainmatters-996	91	7	cells	cell	NOUN
brainmatters-996	91	8	from	from	ADP
brainmatters-996	91	9	patients	patient	NOUN
brainmatters-996	91	10	in	in	ADP
brainmatters-996	91	11	the	the	DET
brainmatters-996	91	12	lab	lab	NOUN
brainmatters-996	91	13	,	,	PUNCT
brainmatters-996	91	14	pulsing	pulse	VERB
brainmatters-996	91	15	them	they	PRON
brainmatters-996	91	16	with	with	ADP
brainmatters-996	91	17	tumor	tumor	NOUN
brainmatters-996	91	18	-	-	PUNCT
brainmatters-996	91	19	specific	specific	ADJ
brainmatters-996	91	20	proteins	protein	NOUN
brainmatters-996	91	21	,	,	PUNCT
brainmatters-996	91	22	and	and	CCONJ
brainmatters-996	91	23	then	then	ADV
brainmatters-996	91	24	re	re	VERB
brainmatters-996	91	25	-	-	PUNCT
brainmatters-996	91	26	injecting	inject	VERB
brainmatters-996	91	27	them	they	PRON
brainmatters-996	91	28	back	back	ADV
brainmatters-996	91	29	into	into	ADP
brainmatters-996	91	30	the	the	DET
brainmatters-996	91	31	same	same	ADJ
brainmatters-996	91	32	patient	patient	NOUN
brainmatters-996	91	33	(	(	PUNCT
brainmatters-996	91	34	heady	heady	PROPN
brainmatters-996	91	35	&	&	CCONJ
brainmatters-996	91	36	sun	sun	PROPN
brainmatters-996	91	37	,	,	PUNCT
brainmatters-996	91	38	2023	2023	NUM
brainmatters-996	91	39	)	)	PUNCT
brainmatters-996	91	40	.	.	PUNCT
brainmatters-996	92	1	by	by	ADP
brainmatters-996	92	2	recreating	recreate	VERB
brainmatters-996	92	3	the	the	DET
brainmatters-996	92	4	priming	prime	VERB
brainmatters-996	92	5	process	process	NOUN
brainmatters-996	92	6	in	in	ADP
brainmatters-996	92	7	dendritic	dendritic	ADJ
brainmatters-996	92	8	cells	cell	NOUN
brainmatters-996	92	9	,	,	PUNCT
brainmatters-996	92	10	the	the	DET
brainmatters-996	92	11	effects	effect	NOUN
brainmatters-996	92	12	of	of	ADP
brainmatters-996	92	13	lymph	lymph	NOUN
brainmatters-996	92	14	node	node	ADJ
brainmatters-996	92	15	activation	activation	NOUN
brainmatters-996	92	16	can	can	AUX
brainmatters-996	92	17	be	be	AUX
brainmatters-996	92	18	re	re	VERB
brainmatters-996	92	19	-	-	VERB
brainmatters-996	92	20	created	create	VERB
brainmatters-996	92	21	as	as	ADV
brainmatters-996	92	22	well	well	ADV
brainmatters-996	92	23	.	.	PUNCT
brainmatters-996	93	1	this	this	PRON
brainmatters-996	93	2	poses	pose	VERB
brainmatters-996	93	3	exciting	exciting	ADJ
brainmatters-996	93	4	possibilities	possibility	NOUN
brainmatters-996	93	5	for	for	ADP
brainmatters-996	93	6	the	the	DET
brainmatters-996	93	7	field	field	NOUN
brainmatters-996	93	8	of	of	ADP
brainmatters-996	93	9	neurooncology	neurooncology	NOUN
brainmatters-996	93	10	.	.	PUNCT
brainmatters-996	94	1	currently	currently	ADV
brainmatters-996	94	2	,	,	PUNCT
brainmatters-996	94	3	the	the	DET
brainmatters-996	94	4	ucla	ucla	NOUN
brainmatters-996	94	5	researchers	researcher	NOUN
brainmatters-996	94	6	are	be	AUX
brainmatters-996	94	7	attempting	attempt	VERB
brainmatters-996	94	8	which	which	DET
brainmatters-996	94	9	immune	immune	ADJ
brainmatters-996	94	10	cells	cell	NOUN
brainmatters-996	94	11	are	be	AUX
brainmatters-996	94	12	changing	change	VERB
brainmatters-996	94	13	in	in	ADP
brainmatters-996	94	14	the	the	DET
brainmatters-996	94	15	more	more	ADV
brainmatters-996	94	16	responsive	responsive	ADJ
brainmatters-996	94	17	tumors	tumor	NOUN
brainmatters-996	94	18	to	to	PART
brainmatters-996	94	19	help	help	VERB
brainmatters-996	94	20	better	well	ADV
brainmatters-996	94	21	explain	explain	VERB
brainmatters-996	94	22	the	the	DET
brainmatters-996	94	23	higher	high	ADJ
brainmatters-996	94	24	response	response	NOUN
brainmatters-996	94	25	rate	rate	NOUN
brainmatters-996	94	26	to	to	ADP
brainmatters-996	94	27	the	the	DET
brainmatters-996	94	28	treatment	treatment	NOUN
brainmatters-996	94	29	.	.	PUNCT
brainmatters-996	95	1	no	no	DET
brainmatters-996	95	2	study	study	NOUN
brainmatters-996	95	3	has	have	AUX
brainmatters-996	95	4	comprehensively	comprehensively	ADV
brainmatters-996	95	5	examined	examine	VERB
brainmatters-996	95	6	the	the	DET
brainmatters-996	95	7	differential	differential	ADJ
brainmatters-996	95	8	effect	effect	NOUN
brainmatters-996	95	9	of	of	ADP
brainmatters-996	95	10	immune	immune	ADJ
brainmatters-996	95	11	checkpoint	checkpoint	NOUN
brainmatters-996	95	12	blockade	blockade	NOUN
brainmatters-996	95	13	treatment	treatment	NOUN
brainmatters-996	95	14	on	on	ADP
brainmatters-996	95	15	these	these	DET
brainmatters-996	95	16	two	two	NUM
brainmatters-996	95	17	types	type	NOUN
brainmatters-996	95	18	of	of	ADP
brainmatters-996	95	19	brain	brain	NOUN
brainmatters-996	95	20	tumors	tumor	NOUN
brainmatters-996	95	21	(	(	PUNCT
brainmatters-996	95	22	those	those	PRON
brainmatters-996	95	23	that	that	PRON
brainmatters-996	95	24	originate	originate	VERB
brainmatters-996	95	25	in	in	ADP
brainmatters-996	95	26	the	the	DET
brainmatters-996	95	27	brain	brain	NOUN
brainmatters-996	95	28	,	,	PUNCT
brainmatters-996	95	29	and	and	CCONJ
brainmatters-996	95	30	those	those	PRON
brainmatters-996	95	31	that	that	PRON
brainmatters-996	95	32	metastasize	metastasize	VERB
brainmatters-996	95	33	to	to	ADP
brainmatters-996	95	34	it	it	PRON
brainmatters-996	95	35	)	)	PUNCT
brainmatters-996	95	36	before	before	ADV
brainmatters-996	95	37	.	.	PUNCT
brainmatters-996	96	1	in	in	ADP
brainmatters-996	96	2	future	future	ADJ
brainmatters-996	96	3	studies	study	NOUN
brainmatters-996	96	4	,	,	PUNCT
brainmatters-996	96	5	the	the	DET
brainmatters-996	96	6	researchers	researcher	NOUN
brainmatters-996	96	7	plan	plan	VERB
brainmatters-996	96	8	to	to	PART
brainmatters-996	96	9	analyze	analyze	VERB
brainmatters-996	96	10	data	datum	NOUN
brainmatters-996	96	11	from	from	ADP
brainmatters-996	96	12	a	a	DET
brainmatters-996	96	13	larger	large	ADJ
brainmatters-996	96	14	,	,	PUNCT
brainmatters-996	96	15	more	more	ADV
brainmatters-996	96	16	uniform	uniform	ADJ
brainmatters-996	96	17	group	group	NOUN
brainmatters-996	96	18	of	of	ADP
brainmatters-996	96	19	people	people	NOUN
brainmatters-996	96	20	who	who	PRON
brainmatters-996	96	21	were	be	AUX
brainmatters-996	96	22	diagnosed	diagnose	VERB
brainmatters-996	96	23	with	with	ADP
brainmatters-996	96	24	melanoma	melanoma	NOUN
brainmatters-996	96	25	that	that	PRON
brainmatters-996	96	26	had	have	AUX
brainmatters-996	96	27	spread	spread	VERB
brainmatters-996	96	28	to	to	ADP
brainmatters-996	96	29	the	the	DET
brainmatters-996	96	30	brain	brain	NOUN
brainmatters-996	96	31	(	(	PUNCT
brainmatters-996	96	32	branca	branca	NOUN
brainmatters-996	96	33	,	,	PUNCT
brainmatters-996	96	34	2023	2023	NUM
brainmatters-996	96	35	)	)	PUNCT
brainmatters-996	96	36	.	.	PUNCT
brainmatters-996	97	1	conclusion	conclusion	NOUN
brainmatters-996	97	2	glioblastoma	glioblastoma	NOUN
brainmatters-996	97	3	arises	arise	VERB
brainmatters-996	97	4	due	due	ADJ
brainmatters-996	97	5	to	to	ADP
brainmatters-996	97	6	genetic	genetic	ADJ
brainmatters-996	97	7	mutations	mutation	NOUN
brainmatters-996	97	8	in	in	ADP
brainmatters-996	97	9	these	these	DET
brainmatters-996	97	10	cells	cell	NOUN
brainmatters-996	97	11	,	,	PUNCT
brainmatters-996	97	12	causing	cause	VERB
brainmatters-996	97	13	uncontrolled	uncontrolled	ADJ
brainmatters-996	97	14	growth	growth	NOUN
brainmatters-996	97	15	.	.	PUNCT
brainmatters-996	98	1	unlike	unlike	ADP
brainmatters-996	98	2	many	many	ADJ
brainmatters-996	98	3	brain	brain	NOUN
brainmatters-996	98	4	tumors	tumor	NOUN
brainmatters-996	98	5	,	,	PUNCT
brainmatters-996	98	6	treating	treat	VERB
brainmatters-996	98	7	glioblastoma	glioblastoma	NOUN
brainmatters-996	98	8	presents	present	VERB
brainmatters-996	98	9	specific	specific	ADJ
brainmatters-996	98	10	hurdles	hurdle	NOUN
brainmatters-996	98	11	.	.	PUNCT
brainmatters-996	99	1	challenges	challenge	NOUN
brainmatters-996	99	2	include	include	VERB
brainmatters-996	99	3	the	the	DET
brainmatters-996	99	4	brain	brain	NOUN
brainmatters-996	99	5	tumor	tumor	NOUN
brainmatters-996	99	6	's	's	PART
brainmatters-996	99	7	location	location	NOUN
brainmatters-996	99	8	,	,	PUNCT
brainmatters-996	99	9	the	the	DET
brainmatters-996	99	10	bbb	bbb	PROPN
brainmatters-996	99	11	,	,	PUNCT
brainmatters-996	99	12	and	and	CCONJ
brainmatters-996	99	13	the	the	DET
brainmatters-996	99	14	brain	brain	NOUN
brainmatters-996	99	15	's	's	PART
brainmatters-996	99	16	limited	limited	ADJ
brainmatters-996	99	17	self	self	NOUN
brainmatters-996	99	18	-	-	PUNCT
brainmatters-996	99	19	repair	repair	NOUN
brainmatters-996	99	20	capacity	capacity	NOUN
brainmatters-996	99	21	.	.	PUNCT
brainmatters-996	100	1	however	however	ADV
brainmatters-996	100	2	,	,	PUNCT
brainmatters-996	100	3	the	the	DET
brainmatters-996	100	4	most	most	ADV
brainmatters-996	100	5	significant	significant	ADJ
brainmatters-996	100	6	challenge	challenge	NOUN
brainmatters-996	100	7	is	be	AUX
brainmatters-996	100	8	its	its	PRON
brainmatters-996	100	9	inherent	inherent	ADJ
brainmatters-996	100	10	resistance	resistance	NOUN
brainmatters-996	100	11	to	to	ADP
brainmatters-996	100	12	standard	standard	ADJ
brainmatters-996	100	13	treatments	treatment	NOUN
brainmatters-996	100	14	.	.	PUNCT
brainmatters-996	101	1	while	while	SCONJ
brainmatters-996	101	2	gbm	gbm	PROPN
brainmatters-996	101	3	has	have	AUX
brainmatters-996	101	4	been	be	AUX
brainmatters-996	101	5	generally	generally	ADV
brainmatters-996	101	6	difficult	difficult	ADJ
brainmatters-996	101	7	to	to	PART
brainmatters-996	101	8	treat	treat	VERB
brainmatters-996	101	9	,	,	PUNCT
brainmatters-996	101	10	immunotherapy	immunotherapy	NOUN
brainmatters-996	101	11	(	(	PUNCT
brainmatters-996	101	12	which	which	PRON
brainmatters-996	101	13	activates	activate	VERB
brainmatters-996	101	14	t	t	PROPN
brainmatters-996	101	15	-	-	PUNCT
brainmatters-996	101	16	cells	cell	NOUN
brainmatters-996	101	17	to	to	PART
brainmatters-996	101	18	target	target	VERB
brainmatters-996	101	19	cancer	cancer	NOUN
brainmatters-996	101	20	cells	cell	NOUN
brainmatters-996	101	21	)	)	PUNCT
brainmatters-996	101	22	has	have	AUX
brainmatters-996	101	23	proven	prove	VERB
brainmatters-996	101	24	to	to	PART
brainmatters-996	101	25	be	be	AUX
brainmatters-996	101	26	particularly	particularly	ADV
brainmatters-996	101	27	unhelpful	unhelpful	ADJ
brainmatters-996	101	28	.	.	PUNCT
brainmatters-996	102	1	new	new	ADJ
brainmatters-996	102	2	studies	study	NOUN
brainmatters-996	102	3	show	show	VERB
brainmatters-996	102	4	that	that	SCONJ
brainmatters-996	102	5	this	this	PRON
brainmatters-996	102	6	could	could	AUX
brainmatters-996	102	7	potentially	potentially	ADV
brainmatters-996	102	8	be	be	AUX
brainmatters-996	102	9	due	due	ADJ
brainmatters-996	102	10	to	to	ADP
brainmatters-996	102	11	a	a	DET
brainmatters-996	102	12	t	t	NOUN
brainmatters-996	102	13	-	-	PUNCT
brainmatters-996	102	14	cell	cell	NOUN
brainmatters-996	102	15	priming	priming	NOUN
brainmatters-996	102	16	step	step	NOUN
brainmatters-996	102	17	that	that	PRON
brainmatters-996	102	18	occurs	occur	VERB
brainmatters-996	102	19	outside	outside	ADP
brainmatters-996	102	20	of	of	ADP
brainmatters-996	102	21	the	the	DET
brainmatters-996	102	22	brain	brain	NOUN
brainmatters-996	102	23	,	,	PUNCT
brainmatters-996	102	24	whereas	whereas	SCONJ
brainmatters-996	102	25	gbm	gbm	NOUN
brainmatters-996	102	26	originates	originate	NOUN
brainmatters-996	102	27	in	in	ADP
brainmatters-996	102	28	the	the	DET
brainmatters-996	102	29	brain	brain	NOUN
brainmatters-996	102	30	.	.	PUNCT
brainmatters-996	103	1	ongoing	ongoing	ADJ
brainmatters-996	103	2	research	research	NOUN
brainmatters-996	103	3	into	into	ADP
brainmatters-996	103	4	t	t	NOUN
brainmatters-996	103	5	-	-	PUNCT
brainmatters-996	103	6	cell	cell	NOUN
brainmatters-996	103	7	activation	activation	NOUN
brainmatters-996	103	8	by	by	ADP
brainmatters-996	103	9	dendritic	dendritic	ADJ
brainmatters-996	103	10	cells	cell	NOUN
brainmatters-996	103	11	offers	offer	VERB
brainmatters-996	103	12	hope	hope	NOUN
brainmatters-996	103	13	for	for	ADP
brainmatters-996	103	14	patients	patient	NOUN
brainmatters-996	103	15	like	like	ADP
brainmatters-996	103	16	henry	henry	PROPN
brainmatters-996	103	17	leonard	leonard	PROPN
brainmatters-996	103	18	.	.	PUNCT
brainmatters-996	104	1	additionally	additionally	ADV
brainmatters-996	104	2	,	,	PUNCT
brainmatters-996	104	3	endothelial	endothelial	ADJ
brainmatters-996	104	4	cells	cell	NOUN
brainmatters-996	104	5	of	of	ADP
brainmatters-996	104	6	vessels	vessel	NOUN
brainmatters-996	104	7	limit	limit	VERB
brainmatters-996	104	8	intercellular	intercellular	ADJ
brainmatters-996	104	9	support	support	NOUN
brainmatters-996	104	10	of	of	ADP
brainmatters-996	104	11	large	large	ADJ
brainmatters-996	104	12	hydrophilic	hydrophilic	ADJ
brainmatters-996	104	13	drugs	drug	NOUN
brainmatters-996	104	14	,	,	PUNCT
brainmatters-996	104	15	a	a	DET
brainmatters-996	104	16	category	category	NOUN
brainmatters-996	104	17	many	many	ADJ
brainmatters-996	104	18	cancer	cancer	NOUN
brainmatters-996	104	19	drugs	drug	NOUN
brainmatters-996	104	20	fall	fall	VERB
brainmatters-996	104	21	into	into	ADP
brainmatters-996	104	22	(	(	PUNCT
brainmatters-996	104	23	ncbi	ncbi	NOUN
brainmatters-996	104	24	,	,	PUNCT
brainmatters-996	104	25	2023	2023	NUM
brainmatters-996	104	26	)	)	PUNCT
brainmatters-996	104	27	.	.	PUNCT
brainmatters-996	105	1	these	these	DET
brainmatters-996	105	2	factors	factor	NOUN
brainmatters-996	105	3	make	make	VERB
brainmatters-996	105	4	many	many	ADJ
brainmatters-996	105	5	therapeutics	therapeutic	NOUN
brainmatters-996	105	6	ineffective	ineffective	ADJ
brainmatters-996	105	7	in	in	ADP
brainmatters-996	105	8	treating	treat	VERB
brainmatters-996	105	9	gbm	gbm	PROPN
brainmatters-996	105	10	.	.	PUNCT
brainmatters-996	106	1	gbm	gbm	PROPN
brainmatters-996	106	2	also	also	ADV
brainmatters-996	106	3	exhibits	exhibit	VERB
brainmatters-996	106	4	interesting	interesting	ADJ
brainmatters-996	106	5	resistance	resistance	NOUN
brainmatters-996	106	6	patterns	pattern	NOUN
brainmatters-996	106	7	that	that	PRON
brainmatters-996	106	8	make	make	VERB
brainmatters-996	106	9	it	it	PRON
brainmatters-996	106	10	difficult	difficult	ADJ
brainmatters-996	106	11	to	to	PART
brainmatters-996	106	12	treat	treat	VERB
brainmatters-996	106	13	.	.	PUNCT
brainmatters-996	107	1	resistance	resistance	NOUN
brainmatters-996	107	2	is	be	AUX
brainmatters-996	107	3	most	most	ADV
brainmatters-996	107	4	commonly	commonly	ADV
brainmatters-996	107	5	acquired	acquire	VERB
brainmatters-996	107	6	through	through	ADP
brainmatters-996	107	7	the	the	DET
brainmatters-996	107	8	mechanism	mechanism	NOUN
brainmatters-996	107	9	of	of	ADP
brainmatters-996	107	10	dna	dna	PROPN
brainmatters-996	107	11	enzyme	enzyme	NOUN
brainmatters-996	107	12	repair	repair	NOUN
brainmatters-996	107	13	.	.	PUNCT
brainmatters-996	108	1	some	some	DET
brainmatters-996	108	2	cancer	cancer	NOUN
brainmatters-996	108	3	drugs	drug	NOUN
brainmatters-996	108	4	(	(	PUNCT
brainmatters-996	108	5	most	most	ADV
brainmatters-996	108	6	notably	notably	ADV
brainmatters-996	108	7	temozolomide	temozolomide	NOUN
brainmatters-996	108	8	)	)	PUNCT
brainmatters-996	108	9	create	create	VERB
brainmatters-996	108	10	methyl	methyl	NOUN
brainmatters-996	108	11	adducts	adduct	NOUN
brainmatters-996	108	12	,	,	PUNCT
brainmatters-996	108	13	which	which	PRON
brainmatters-996	108	14	inhibit	inhibit	VERB
brainmatters-996	108	15	normal	normal	ADJ
brainmatters-996	108	16	functions	function	NOUN
brainmatters-996	108	17	,	,	PUNCT
brainmatters-996	108	18	on	on	ADP
brainmatters-996	108	19	dna	dna	PROPN
brainmatters-996	108	20	.	.	PUNCT
brainmatters-996	109	1	this	this	DET
brainmatters-996	109	2	modification	modification	NOUN
brainmatters-996	109	3	is	be	AUX
brainmatters-996	109	4	toxic	toxic	ADJ
brainmatters-996	109	5	to	to	ADP
brainmatters-996	109	6	the	the	DET
brainmatters-996	109	7	cell	cell	NOUN
brainmatters-996	109	8	's	's	PART
brainmatters-996	109	9	dna	dna	NOUN
brainmatters-996	109	10	and	and	CCONJ
brainmatters-996	109	11	can	can	AUX
brainmatters-996	109	12	trigger	trigger	VERB
brainmatters-996	109	13	cell	cell	NOUN
brainmatters-996	109	14	death	death	NOUN
brainmatters-996	109	15	.	.	PUNCT
brainmatters-996	110	1	however	however	ADV
brainmatters-996	110	2	,	,	PUNCT
brainmatters-996	110	3	the	the	DET
brainmatters-996	110	4	repair	repair	NOUN
brainmatters-996	110	5	enzyme	enzyme	NOUN
brainmatters-996	110	6	o6	o6	NOUN
brainmatters-996	110	7	-	-	PUNCT
brainmatters-996	110	8	methylguanine	methylguanine	NOUN
brainmatters-996	110	9	-	-	PUNCT
brainmatters-996	110	10	dna	dna	NOUN
brainmatters-996	110	11	methyltransferase	methyltransferase	NOUN
brainmatters-996	110	12	(	(	PUNCT
brainmatters-996	110	13	mgmt	mgmt	PROPN
brainmatters-996	110	14	)	)	PUNCT
brainmatters-996	110	15	is	be	AUX
brainmatters-996	110	16	capable	capable	ADJ
brainmatters-996	110	17	of	of	ADP
brainmatters-996	110	18	reversing	reverse	VERB
brainmatters-996	110	19	this	this	DET
brainmatters-996	110	20	methyl	methyl	NOUN
brainmatters-996	110	21	adduct	adduct	NOUN
brainmatters-996	110	22	,	,	PUNCT
brainmatters-996	110	23	effectively	effectively	ADV
brainmatters-996	110	24	repairing	repair	VERB
brainmatters-996	110	25	the	the	DET
brainmatters-996	110	26	damaged	damage	VERB
brainmatters-996	110	27	dna	dna	NOUN
brainmatters-996	110	28	before	before	SCONJ
brainmatters-996	110	29	it	it	PRON
brainmatters-996	110	30	leads	lead	VERB
brainmatters-996	110	31	to	to	ADP
brainmatters-996	110	32	cell	cell	NOUN
brainmatters-996	110	33	death	death	NOUN
brainmatters-996	110	34	(	(	PUNCT
brainmatters-996	110	35	ncbi	ncbi	NOUN
brainmatters-996	110	36	,	,	PUNCT
brainmatters-996	110	37	2020	2020	NUM
brainmatters-996	110	38	)	)	PUNCT
brainmatters-996	110	39	.	.	PUNCT
brainmatters-996	111	1	this	this	DET
brainmatters-996	111	2	repair	repair	NOUN
brainmatters-996	111	3	process	process	NOUN
brainmatters-996	111	4	prevents	prevent	VERB
brainmatters-996	111	5	cell	cell	NOUN
brainmatters-996	111	6	death	death	NOUN
brainmatters-996	111	7	and	and	CCONJ
brainmatters-996	111	8	allows	allow	VERB
brainmatters-996	111	9	cancer	cancer	NOUN
brainmatters-996	111	10	cells	cell	NOUN
brainmatters-996	111	11	to	to	PART
brainmatters-996	111	12	survive	survive	VERB
brainmatters-996	111	13	the	the	DET
brainmatters-996	111	14	chemotherapy	chemotherapy	NOUN
brainmatters-996	111	15	's	's	PART
brainmatters-996	111	16	intended	intend	VERB
brainmatters-996	111	17	effects	effect	NOUN
brainmatters-996	111	18	(	(	PUNCT
brainmatters-996	111	19	ncbi	ncbi	NOUN
brainmatters-996	111	20	,	,	PUNCT
brainmatters-996	111	21	2020	2020	NUM
brainmatters-996	111	22	)	)	PUNCT
brainmatters-996	111	23	.	.	PUNCT
brainmatters-996	112	1	immunotherapies	immunotherapy	NOUN
brainmatters-996	112	2	in	in	ADP
brainmatters-996	112	3	treating	treat	VERB
brainmatters-996	112	4	cancer	cancer	NOUN
brainmatters-996	112	5	while	while	SCONJ
brainmatters-996	112	6	there	there	PRON
brainmatters-996	112	7	are	be	VERB
brainmatters-996	112	8	a	a	DET
brainmatters-996	112	9	few	few	ADJ
brainmatters-996	112	10	options	option	NOUN
brainmatters-996	112	11	available	available	ADJ
brainmatters-996	112	12	for	for	ADP
brainmatters-996	112	13	gbm	gbm	NOUN
brainmatters-996	112	14	patients	patient	NOUN
brainmatters-996	112	15	,	,	PUNCT
brainmatters-996	112	16	immunotherapy	immunotherapy	NOUN
brainmatters-996	112	17	is	be	AUX
brainmatters-996	112	18	not	not	PART
brainmatters-996	112	19	one	one	NUM
brainmatters-996	112	20	of	of	ADP
brainmatters-996	112	21	them	they	PRON
brainmatters-996	112	22	.	.	PUNCT
brainmatters-996	113	1	immunotherapy	immunotherapy	NOUN
brainmatters-996	113	2	has	have	AUX
brainmatters-996	113	3	been	be	AUX
brainmatters-996	113	4	proven	prove	VERB
brainmatters-996	113	5	to	to	PART
brainmatters-996	113	6	be	be	AUX
brainmatters-996	113	7	effective	effective	ADJ
brainmatters-996	113	8	for	for	ADP
brainmatters-996	113	9	various	various	ADJ
brainmatters-996	113	10	other	other	ADJ
brainmatters-996	113	11	cancers	cancer	NOUN
brainmatters-996	113	12	,	,	PUNCT
brainmatters-996	113	13	including	include	VERB
brainmatters-996	113	14	some	some	PRON
brainmatters-996	113	15	that	that	PRON
brainmatters-996	113	16	frequently	frequently	ADV
brainmatters-996	113	17	metastasize	metastasize	VERB
brainmatters-996	113	18	to	to	ADP
brainmatters-996	113	19	the	the	DET
brainmatters-996	113	20	brain	brain	NOUN
brainmatters-996	113	21	.	.	PUNCT
brainmatters-996	114	1	melanoma	melanoma	NOUN
brainmatters-996	114	2	,	,	PUNCT
brainmatters-996	114	3	kidney	kidney	NOUN
brainmatters-996	114	4	cancer	cancer	NOUN
brainmatters-996	114	5	,	,	PUNCT
brainmatters-996	114	6	and	and	CCONJ
brainmatters-996	114	7	breast	breast	NOUN
brainmatters-996	114	8	cancer	cancer	NOUN
brainmatters-996	114	9	are	be	AUX
brainmatters-996	114	10	among	among	ADP
brainmatters-996	114	11	these	these	PRON
brainmatters-996	114	12	.	.	PUNCT
brainmatters-996	115	1	however	however	ADV
brainmatters-996	115	2	,	,	PUNCT
brainmatters-996	115	3	as	as	SCONJ
brainmatters-996	115	4	gbm	gbm	PROPN
brainmatters-996	115	5	does	do	AUX
brainmatters-996	115	6	originate	originate	VERB
brainmatters-996	115	7	in	in	ADP
brainmatters-996	115	8	the	the	DET
brainmatters-996	115	9	brain	brain	NOUN
brainmatters-996	115	10	,	,	PUNCT
brainmatters-996	115	11	immunotherapy	immunotherapy	NOUN
brainmatters-996	115	12	has	have	AUX
brainmatters-996	115	13	not	not	PART
brainmatters-996	115	14	been	be	AUX
brainmatters-996	115	15	seen	see	VERB
brainmatters-996	115	16	to	to	PART
brainmatters-996	115	17	be	be	AUX
brainmatters-996	115	18	effective	effective	ADJ
brainmatters-996	115	19	.	.	PUNCT
brainmatters-996	116	1	in	in	ADP
brainmatters-996	116	2	tumors	tumor	NOUN
brainmatters-996	116	3	that	that	PRON
brainmatters-996	116	4	do	do	AUX
brainmatters-996	116	5	n’t	not	PART
brainmatters-996	116	6	originate	originate	VERB
brainmatters-996	116	7	in	in	ADP
brainmatters-996	116	8	the	the	DET
brainmatters-996	116	9	brain	brain	NOUN
brainmatters-996	116	10	(	(	PUNCT
brainmatters-996	116	11	but	but	CCONJ
brainmatters-996	116	12	may	may	AUX
brainmatters-996	116	13	potentially	potentially	ADV
brainmatters-996	116	14	metastasize	metastasize	VERB
brainmatters-996	116	15	to	to	ADP
brainmatters-996	116	16	the	the	DET
brainmatters-996	116	17	brain	brain	NOUN
brainmatters-996	116	18	)	)	PUNCT
brainmatters-996	116	19	,	,	PUNCT
brainmatters-996	116	20	drugs	drug	NOUN
brainmatters-996	116	21	called	call	VERB
brainmatters-996	116	22	immune	immune	ADJ
brainmatters-996	116	23	checkpoint	checkpoint	NOUN
brainmatters-996	116	24	inhibitors	inhibitor	NOUN
brainmatters-996	116	25	are	be	AUX
brainmatters-996	116	26	used	use	VERB
brainmatters-996	116	27	.	.	PUNCT
brainmatters-996	117	1	human	human	ADJ
brainmatters-996	117	2	immune	immune	ADJ
brainmatters-996	117	3	systems	system	NOUN
brainmatters-996	117	4	have	have	VERB
brainmatters-996	117	5	several	several	ADJ
brainmatters-996	117	6	checkpoints	checkpoint	NOUN
brainmatters-996	117	7	to	to	PART
brainmatters-996	117	8	regulate	regulate	VERB
brainmatters-996	117	9	immune	immune	ADJ
brainmatters-996	117	10	responses	response	NOUN
brainmatters-996	117	11	and	and	CCONJ
brainmatters-996	117	12	prevent	prevent	VERB
brainmatters-996	117	13	the	the	DET
brainmatters-996	117	14	immune	immune	ADJ
brainmatters-996	117	15	system	system	NOUN
brainmatters-996	117	16	from	from	ADP
brainmatters-996	117	17	attacking	attack	VERB
brainmatters-996	117	18	healthy	healthy	ADJ
brainmatters-996	117	19	cells	cell	NOUN
brainmatters-996	117	20	.	.	PUNCT
brainmatters-996	118	1	however	however	ADV
brainmatters-996	118	2	,	,	PUNCT
brainmatters-996	118	3	cancer	cancer	NOUN
brainmatters-996	118	4	cells	cell	NOUN
brainmatters-996	118	5	can	can	AUX
brainmatters-996	118	6	often	often	ADV
brainmatters-996	118	7	take	take	VERB
brainmatters-996	118	8	advantage	advantage	NOUN
brainmatters-996	118	9	of	of	ADP
brainmatters-996	118	10	these	these	DET
brainmatters-996	118	11	checkpoints	checkpoint	NOUN
brainmatters-996	118	12	to	to	PART
brainmatters-996	118	13	avoid	avoid	VERB
brainmatters-996	118	14	being	be	AUX
brainmatters-996	118	15	attacked	attack	VERB
brainmatters-996	118	16	by	by	ADP
brainmatters-996	118	17	the	the	DET
brainmatters-996	118	18	immune	immune	ADJ
brainmatters-996	118	19	system	system	NOUN
brainmatters-996	118	20	.	.	PUNCT
brainmatters-996	119	1	immune	immune	ADJ
brainmatters-996	119	2	checkpoint	checkpoint	NOUN
brainmatters-996	119	3	inhibitors	inhibitor	NOUN
brainmatters-996	119	4	are	be	AUX
brainmatters-996	119	5	drugs	drug	NOUN
brainmatters-996	119	6	that	that	PRON
brainmatters-996	119	7	block	block	VERB
brainmatters-996	119	8	these	these	DET
brainmatters-996	119	9	checkpoints	checkpoint	NOUN
brainmatters-996	119	10	,	,	PUNCT
brainmatters-996	119	11	allowing	allow	VERB
brainmatters-996	119	12	it	it	PRON
brainmatters-996	119	13	to	to	PART
brainmatters-996	119	14	recognize	recognize	VERB
brainmatters-996	119	15	and	and	CCONJ
brainmatters-996	119	16	attack	attack	NOUN
brainmatters-996	119	17	cancer	cancer	NOUN
brainmatters-996	119	18	cells	cell	NOUN
brainmatters-996	119	19	more	more	ADV
brainmatters-996	119	20	effectively	effectively	ADV
brainmatters-996	119	21	.	.	PUNCT
brainmatters-996	120	1	these	these	DET
brainmatters-996	120	2	drugs	drug	NOUN
brainmatters-996	120	3	have	have	AUX
brainmatters-996	120	4	been	be	AUX
brainmatters-996	120	5	found	find	VERB
brainmatters-996	120	6	to	to	PART
brainmatters-996	120	7	elicit	elicit	VERB
brainmatters-996	120	8	a	a	DET
brainmatters-996	120	9	significant	significant	ADJ
brainmatters-996	120	10	increase	increase	NOUN
brainmatters-996	120	11	in	in	ADP
brainmatters-996	120	12	both	both	CCONJ
brainmatters-996	120	13	active	active	ADJ
brainmatters-996	120	14	and	and	CCONJ
brainmatters-996	120	15	exhausted	exhausted	ADJ
brainmatters-996	120	16	t	t	NOUN
brainmatters-996	120	17	cells	cell	NOUN
brainmatters-996	120	18	—	—	PUNCT
brainmatters-996	120	19	signs	sign	NOUN
brainmatters-996	120	20	that	that	SCONJ
brainmatters-996	120	21	the	the	DET
brainmatters-996	120	22	t	t	PROPN
brainmatters-996	120	23	cells	cell	NOUN
brainmatters-996	120	24	have	have	AUX
brainmatters-996	120	25	been	be	AUX
brainmatters-996	120	26	triggered	trigger	VERB
brainmatters-996	120	27	to	to	PART
brainmatters-996	120	28	fight	fight	VERB
brainmatters-996	120	29	the	the	DET
brainmatters-996	120	30	cancer	cancer	NOUN
brainmatters-996	120	31	(	(	PUNCT
brainmatters-996	120	32	heady	heady	PROPN
brainmatters-996	120	33	&	&	CCONJ
brainmatters-996	120	34	sun	sun	PROPN
brainmatters-996	120	35	,	,	PUNCT
brainmatters-996	120	36	2023	2023	NUM
brainmatters-996	120	37	)	)	PUNCT
brainmatters-996	120	38	.	.	PUNCT
brainmatters-996	121	1	when	when	SCONJ
brainmatters-996	121	2	the	the	DET
brainmatters-996	121	3	checkpoints	checkpoint	NOUN
brainmatters-996	121	4	are	be	AUX
brainmatters-996	121	5	blocked	block	VERB
brainmatters-996	121	6	,	,	PUNCT
brainmatters-996	121	7	the	the	DET
brainmatters-996	121	8	immune	immune	ADJ
brainmatters-996	121	9	system	system	NOUN
brainmatters-996	121	10	's	's	PART
brainmatters-996	121	11	killer	killer	NOUN
brainmatters-996	121	12	t	t	PROPN
brainmatters-996	121	13	-	-	PUNCT
brainmatters-996	121	14	cells	cell	NOUN
brainmatters-996	121	15	become	become	VERB
brainmatters-996	121	16	more	more	ADV
brainmatters-996	121	17	active	active	ADJ
brainmatters-996	121	18	and	and	CCONJ
brainmatters-996	121	19	capable	capable	ADJ
brainmatters-996	121	20	of	of	ADP
brainmatters-996	121	21	recognizing	recognize	VERB
brainmatters-996	121	22	cancer	cancer	NOUN
brainmatters-996	121	23	cells	cell	NOUN
brainmatters-996	121	24	as	as	ADP
brainmatters-996	121	25	threats	threat	NOUN
brainmatters-996	121	26	.	.	PUNCT
brainmatters-996	122	1	t	t	NOUN
brainmatters-996	122	2	-	-	PUNCT
brainmatters-996	122	3	cells	cell	NOUN
brainmatters-996	122	4	are	be	AUX
brainmatters-996	122	5	activated	activate	VERB
brainmatters-996	122	6	in	in	ADP
brainmatters-996	122	7	lymph	lymph	NOUN
brainmatters-996	122	8	nodes	node	NOUN
brainmatters-996	122	9	.	.	PUNCT
brainmatters-996	123	1	during	during	ADP
brainmatters-996	123	2	this	this	DET
brainmatters-996	123	3	process	process	NOUN
brainmatters-996	123	4	,	,	PUNCT
brainmatters-996	123	5	antigen	antigen	ADJ
brainmatters-996	123	6	presenting	present	VERB
brainmatters-996	123	7	cells	cell	NOUN
brainmatters-996	123	8	are	be	AUX
brainmatters-996	123	9	recruited	recruit	VERB
brainmatters-996	123	10	to	to	ADP
brainmatters-996	123	11	the	the	DET
brainmatters-996	123	12	tumor	tumor	NOUN
brainmatters-996	123	13	,	,	PUNCT
brainmatters-996	123	14	where	where	SCONJ
brainmatters-996	123	15	they	they	PRON
brainmatters-996	123	16	phagocytose	phagocytose	VERB
brainmatters-996	123	17	dead	dead	ADJ
brainmatters-996	123	18	or	or	CCONJ
brainmatters-996	123	19	dying	die	VERB
brainmatters-996	123	20	tumor	tumor	NOUN
brainmatters-996	123	21	cells	cell	NOUN
brainmatters-996	123	22	(	(	PUNCT
brainmatters-996	123	23	heady	heady	PROPN
brainmatters-996	123	24	&	&	CCONJ
brainmatters-996	123	25	sun	sun	PROPN
brainmatters-996	123	26	,	,	PUNCT
brainmatters-996	123	27	2023	2023	NUM
brainmatters-996	123	28	)	)	PUNCT
brainmatters-996	123	29	.	.	PUNCT
brainmatters-996	124	1	receptors	receptor	NOUN
brainmatters-996	124	2	on	on	ADP
brainmatters-996	124	3	the	the	DET
brainmatters-996	124	4	dead	dead	ADJ
brainmatters-996	124	5	cells	cell	NOUN
brainmatters-996	124	6	activate	activate	VERB
brainmatters-996	124	7	the	the	DET
brainmatters-996	124	8	antigen	antigen	NOUN
brainmatters-996	124	9	-	-	PUNCT
brainmatters-996	124	10	presenting	present	VERB
brainmatters-996	124	11	cells	cell	NOUN
brainmatters-996	124	12	and	and	CCONJ
brainmatters-996	124	13	these	these	DET
brainmatters-996	124	14	cells	cell	NOUN
brainmatters-996	124	15	then	then	ADV
brainmatters-996	124	16	migrate	migrate	VERB
brainmatters-996	124	17	to	to	ADP
brainmatters-996	124	18	the	the	DET
brainmatters-996	124	19	nearest	near	ADJ
brainmatters-996	124	20	lymph	lymph	NOUN
brainmatters-996	124	21	node	node	NOUN
brainmatters-996	124	22	and	and	CCONJ
brainmatters-996	124	23	prime	prime	ADJ
brainmatters-996	124	24	naïve	naïve	PROPN
brainmatters-996	124	25	t	t	NOUN
brainmatters-996	124	26	cells	cell	NOUN
brainmatters-996	124	27	moving	move	VERB
brainmatters-996	124	28	through	through	ADP
brainmatters-996	124	29	there	there	ADV
brainmatters-996	124	30	,	,	PUNCT
brainmatters-996	124	31	allowing	allow	VERB
brainmatters-996	124	32	the	the	DET
brainmatters-996	124	33	immune	immune	ADJ
brainmatters-996	124	34	system	system	NOUN
brainmatters-996	124	35	to	to	PART
brainmatters-996	124	36	continue	continue	VERB
brainmatters-996	124	37	to	to	PART
brainmatters-996	124	38	target	target	VERB
brainmatters-996	124	39	the	the	DET
brainmatters-996	124	40	tumor	tumor	NOUN
brainmatters-996	124	41	(	(	PUNCT
brainmatters-996	124	42	branca	branca	NOUN
brainmatters-996	124	43	,	,	PUNCT
brainmatters-996	124	44	2023	2023	NUM
brainmatters-996	124	45	)	)	PUNCT
brainmatters-996	124	46	.	.	PUNCT
brainmatters-996	125	1	in	in	ADP
brainmatters-996	125	2	gbm	gbm	PROPN
brainmatters-996	125	3	,	,	PUNCT
brainmatters-996	125	4	and	and	CCONJ
brainmatters-996	125	5	other	other	ADJ
brainmatters-996	125	6	tumors	tumor	NOUN
brainmatters-996	125	7	originating	originate	VERB
brainmatters-996	125	8	in	in	ADP
brainmatters-996	125	9	the	the	DET
brainmatters-996	125	10	brain	brain	NOUN
brainmatters-996	125	11	,	,	PUNCT
brainmatters-996	125	12	however	however	ADV
brainmatters-996	125	13	,	,	PUNCT
brainmatters-996	125	14	this	this	DET
brainmatters-996	125	15	t	t	NOUN
brainmatters-996	125	16	cell	cell	NOUN
brainmatters-996	125	17	priming	priming	NOUN
brainmatters-996	125	18	process	process	NOUN
brainmatters-996	125	19	is	be	AUX
brainmatters-996	125	20	n’t	not	PART
brainmatters-996	125	21	effective	effective	ADJ
brainmatters-996	125	22	–	–	PUNCT
brainmatters-996	125	23	leading	lead	VERB
brainmatters-996	125	24	to	to	ADP
brainmatters-996	125	25	the	the	DET
brainmatters-996	125	26	lack	lack	NOUN
brainmatters-996	125	27	of	of	ADP
brainmatters-996	125	28	response	response	NOUN
brainmatters-996	125	29	to	to	ADP
brainmatters-996	125	30	immunotherapy	immunotherapy	NOUN
brainmatters-996	125	31	treatments	treatment	NOUN
brainmatters-996	125	32	.	.	PUNCT
brainmatters-996	126	1	researchers	researcher	NOUN
brainmatters-996	126	2	have	have	AUX
brainmatters-996	126	3	found	find	VERB
brainmatters-996	126	4	a	a	DET
brainmatters-996	126	5	significant	significant	ADJ
brainmatters-996	126	6	difference	difference	NOUN
brainmatters-996	126	7	in	in	ADP
brainmatters-996	126	8	the	the	DET
brainmatters-996	126	9	way	way	NOUN
brainmatters-996	126	10	the	the	DET
brainmatters-996	126	11	two	two	NUM
brainmatters-996	126	12	types	type	NOUN
brainmatters-996	126	13	of	of	ADP
brainmatters-996	126	14	tumors	tumor	NOUN
brainmatters-996	126	15	(	(	PUNCT
brainmatters-996	126	16	those	those	PRON
brainmatters-996	126	17	that	that	PRON
brainmatters-996	126	18	originate	originate	VERB
brainmatters-996	126	19	in	in	ADP
brainmatters-996	126	20	the	the	DET
brainmatters-996	126	21	brain	brain	NOUN
brainmatters-996	126	22	,	,	PUNCT
brainmatters-996	126	23	and	and	CCONJ
brainmatters-996	126	24	those	those	PRON
brainmatters-996	126	25	that	that	PRON
brainmatters-996	126	26	do	do	VERB
brainmatters-996	126	27	n’t	not	PART
brainmatters-996	126	28	)	)	PUNCT
brainmatters-996	126	29	respond	respond	VERB
brainmatters-996	126	30	to	to	ADP
brainmatters-996	126	31	immunotherapy	immunotherapy	NOUN
brainmatters-996	126	32	.	.	PUNCT
brainmatters-996	127	1	in	in	ADP
brainmatters-996	127	2	a	a	DET
brainmatters-996	127	3	study	study	NOUN
brainmatters-996	127	4	by	by	ADP
brainmatters-996	127	5	ucla	ucla	NOUN
brainmatters-996	127	6	,	,	PUNCT
brainmatters-996	127	7	researchers	researcher	NOUN
brainmatters-996	127	8	brain	brain	VERB
brainmatters-996	127	9	matters・volume	matters・volume	PROPN
brainmatters-996	127	10	vii	vii	PROPN
brainmatters-996	127	11	44	44	NUM
brainmatters-996	127	12	14	14	NUM
brainmatters-996	127	13	.	.	PUNCT
brainmatters-996	128	1	molecular	molecular	ADJ
brainmatters-996	128	2	mechanisms	mechanism	NOUN
brainmatters-996	128	3	of	of	ADP
brainmatters-996	128	4	treatment	treatment	NOUN
brainmatters-996	128	5	resistance	resistance	NOUN
brainmatters-996	128	6	in	in	ADP
brainmatters-996	128	7	glioblastoma	glioblastoma	NOUN
brainmatters-996	128	8	.	.	PUNCT
brainmatters-996	129	1	(	(	PUNCT
brainmatters-996	129	2	2020	2020	NUM
brainmatters-996	129	3	,	,	PUNCT
brainmatters-996	129	4	december	december	PROPN
brainmatters-996	129	5	31	31	NUM
brainmatters-996	129	6	)	)	PUNCT
brainmatters-996	129	7	.	.	PUNCT
brainmatters-996	130	1	ncbi	ncbi	NOUN
brainmatters-996	130	2	.	.	PUNCT
brainmatters-996	131	1	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7794986/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7794986/	PROPN
brainmatters-996	131	2	15	15	NUM
brainmatters-996	131	3	.	.	PUNCT
brainmatters-996	132	1	recurrent	recurrent	ADJ
brainmatters-996	132	2	glioblastoma	glioblastoma	NOUN
brainmatters-996	132	3	:	:	PUNCT
brainmatters-996	132	4	a	a	DET
brainmatters-996	132	5	review	review	NOUN
brainmatters-996	132	6	of	of	ADP
brainmatters-996	132	7	the	the	DET
brainmatters-996	132	8	treatment	treatment	NOUN
brainmatters-996	132	9	options	option	NOUN
brainmatters-996	132	10	.	.	PUNCT
brainmatters-996	133	1	(	(	PUNCT
brainmatters-996	133	2	2023	2023	NUM
brainmatters-996	133	3	,	,	PUNCT
brainmatters-996	133	4	august	august	PROPN
brainmatters-996	133	5	26	26	NUM
brainmatters-996	133	6	)	)	PUNCT
brainmatters-996	133	7	.	.	PUNCT
brainmatters-996	134	1	ncbi	ncbi	NOUN
brainmatters-996	134	2	.	.	PUNCT
brainmatters-996	135	1	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc10487236/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc10487236/	PROPN
brainmatters-996	135	2	moving	move	VERB
brainmatters-996	135	3	forward	forward	ADV
brainmatters-996	135	4	,	,	PUNCT
brainmatters-996	135	5	many	many	ADJ
brainmatters-996	135	6	scientists	scientist	NOUN
brainmatters-996	135	7	suggest	suggest	VERB
brainmatters-996	135	8	a	a	DET
brainmatters-996	135	9	holistic	holistic	ADJ
brainmatters-996	135	10	approach	approach	NOUN
brainmatters-996	135	11	that	that	PRON
brainmatters-996	135	12	combines	combine	VERB
brainmatters-996	135	13	innovative	innovative	ADJ
brainmatters-996	135	14	therapies	therapy	NOUN
brainmatters-996	135	15	,	,	PUNCT
brainmatters-996	135	16	personalized	personalized	ADJ
brainmatters-996	135	17	medicine	medicine	NOUN
brainmatters-996	135	18	,	,	PUNCT
brainmatters-996	135	19	and	and	CCONJ
brainmatters-996	135	20	current	current	ADJ
brainmatters-996	135	21	chemotherapies	chemotherapy	NOUN
brainmatters-996	135	22	.	.	PUNCT
brainmatters-996	136	1	this	this	DET
brainmatters-996	136	2	collective	collective	ADJ
brainmatters-996	136	3	momentum	momentum	NOUN
brainmatters-996	136	4	in	in	ADP
brainmatters-996	136	5	research	research	NOUN
brainmatters-996	136	6	not	not	PART
brainmatters-996	136	7	only	only	ADV
brainmatters-996	136	8	aims	aim	VERB
brainmatters-996	136	9	to	to	PART
brainmatters-996	136	10	improve	improve	VERB
brainmatters-996	136	11	survival	survival	NOUN
brainmatters-996	136	12	rates	rate	NOUN
brainmatters-996	136	13	but	but	CCONJ
brainmatters-996	136	14	also	also	ADV
brainmatters-996	136	15	prioritizes	prioritize	VERB
brainmatters-996	136	16	enhancing	enhance	VERB
brainmatters-996	136	17	the	the	DET
brainmatters-996	136	18	quality	quality	NOUN
brainmatters-996	136	19	of	of	ADP
brainmatters-996	136	20	life	life	NOUN
brainmatters-996	136	21	for	for	ADP
brainmatters-996	136	22	individuals	individual	NOUN
brainmatters-996	136	23	facing	face	VERB
brainmatters-996	136	24	this	this	DET
brainmatters-996	136	25	challenging	challenging	ADJ
brainmatters-996	136	26	diagnosis	diagnosis	NOUN
brainmatters-996	136	27	.	.	PUNCT
brainmatters-996	137	1	references	reference	NOUN
brainmatters-996	137	2	1	1	NUM
brainmatters-996	137	3	.	.	PUNCT
brainmatters-996	137	4	arvanitis	arvanitis	NOUN
brainmatters-996	137	5	,	,	PUNCT
brainmatters-996	137	6	c.	c.	PROPN
brainmatters-996	137	7	d.	d.	PROPN
brainmatters-996	137	8	,	,	PUNCT
brainmatters-996	137	9	ferraro	ferraro	PROPN
brainmatters-996	137	10	,	,	PUNCT
brainmatters-996	137	11	g.	g.	PROPN
brainmatters-996	137	12	b.	b.	PROPN
brainmatters-996	137	13	,	,	PUNCT
brainmatters-996	137	14	&	&	CCONJ
brainmatters-996	137	15	jain	jain	PROPN
brainmatters-996	137	16	,	,	PUNCT
brainmatters-996	137	17	r.	r.	PROPN
brainmatters-996	137	18	k.	k.	PROPN
brainmatters-996	137	19	(	(	PUNCT
brainmatters-996	137	20	2020	2020	NUM
brainmatters-996	137	21	)	)	PUNCT
brainmatters-996	137	22	.	.	PUNCT
brainmatters-996	138	1	the	the	DET
brainmatters-996	138	2	blood	blood	NOUN
brainmatters-996	138	3	-	-	PUNCT
brainmatters-996	138	4	brain	brain	NOUN
brainmatters-996	138	5	barrier	barrier	NOUN
brainmatters-996	138	6	and	and	CCONJ
brainmatters-996	138	7	blood	blood	NOUN
brainmatters-996	138	8	-	-	PUNCT
brainmatters-996	138	9	tumour	tumour	NOUN
brainmatters-996	138	10	barrier	barrier	NOUN
brainmatters-996	138	11	in	in	ADP
brainmatters-996	138	12	brain	brain	NOUN
brainmatters-996	138	13	tumours	tumour	NOUN
brainmatters-996	138	14	and	and	CCONJ
brainmatters-996	138	15	metastases	metastasis	NOUN
brainmatters-996	138	16	.	.	PUNCT
brainmatters-996	139	1	nature	nature	NOUN
brainmatters-996	139	2	reviews	review	NOUN
brainmatters-996	139	3	.	.	PUNCT
brainmatters-996	140	1	cancer	cancer	NOUN
brainmatters-996	140	2	,	,	PUNCT
brainmatters-996	140	3	20(1	20(1	NUM
brainmatters-996	140	4	)	)	PUNCT
brainmatters-996	140	5	,	,	PUNCT
brainmatters-996	140	6	26–41	26–41	NUM
brainmatters-996	140	7	.	.	PUNCT
brainmatters-996	141	1	https://doi.org/10.1038/s41568-019-0205-x	https://doi.org/10.1038/s41568-019-0205-x	PROPN
brainmatters-996	141	2	2	2	NUM
brainmatters-996	141	3	.	.	X
brainmatters-996	141	4	branca	branca	NOUN
brainmatters-996	141	5	,	,	PUNCT
brainmatters-996	141	6	m.	m.	NOUN
brainmatters-996	141	7	(	(	PUNCT
brainmatters-996	141	8	2023	2023	NUM
brainmatters-996	141	9	,	,	PUNCT
brainmatters-996	141	10	september	september	PROPN
brainmatters-996	141	11	6	6	NUM
brainmatters-996	141	12	)	)	PUNCT
brainmatters-996	141	13	.	.	PUNCT
brainmatters-996	142	1	why	why	SCONJ
brainmatters-996	142	2	glioblastoma	glioblastoma	NOUN
brainmatters-996	142	3	does	do	AUX
brainmatters-996	142	4	not	not	PART
brainmatters-996	142	5	respond	respond	VERB
brainmatters-996	142	6	to	to	ADP
brainmatters-996	142	7	immunotherapy	immunotherapy	NOUN
brainmatters-996	142	8	,	,	PUNCT
brainmatters-996	142	9	but	but	CCONJ
brainmatters-996	142	10	other	other	ADJ
brainmatters-996	142	11	brain	brain	NOUN
brainmatters-996	142	12	cancers	cancer	NOUN
brainmatters-996	142	13	do	do	VERB
brainmatters-996	142	14	.	.	PUNCT
brainmatters-996	143	1	inside	inside	ADP
brainmatters-996	143	2	precision	precision	NOUN
brainmatters-996	143	3	medicine	medicine	NOUN
brainmatters-996	143	4	.	.	PUNCT
brainmatters-996	144	1	https://www.insideprecisionmedicine.com/topics/oncology/wh	https://www.insideprecisionmedicine.com/topics/oncology/wh	PROPN
brainmatters-996	145	1	y	y	NOUN
brainmatters-996	145	2	-	-	PUNCT
brainmatters-996	145	3	glioblastoma	glioblastoma	NOUN
brainmatters-996	145	4	-	-	PUNCT
brainmatters-996	145	5	does	does	AUX
brainmatters-996	145	6	-	-	PUNCT
brainmatters-996	145	7	not	not	PART
brainmatters-996	145	8	-	-	PUNCT
brainmatters-996	145	9	respond	respond	VERB
brainmatters-996	145	10	-	-	PUNCT
brainmatters-996	145	11	to	to	ADP
brainmatters-996	145	12	-	-	PUNCT
brainmatters-996	145	13	immunotherapy	immunotherapy	NOUN
brainmatters-996	145	14	-	-	PUNCT
brainmatters-996	145	15	butother	butother	NOUN
brainmatters-996	145	16	-	-	PUNCT
brainmatters-996	145	17	brain	brain	NOUN
brainmatters-996	145	18	-	-	PUNCT
brainmatters-996	145	19	cancers	cancer	NOUN
brainmatters-996	145	20	-	-	PUNCT
brainmatters-996	145	21	do/	do/	NOUN
brainmatters-996	145	22	3	3	NUM
brainmatters-996	145	23	.	.	PUNCT
brainmatters-996	145	24	cancer	cancer	NOUN
brainmatters-996	145	25	survival	survival	NOUN
brainmatters-996	145	26	rates	rate	NOUN
brainmatters-996	145	27	.	.	PUNCT
brainmatters-996	146	1	(	(	PUNCT
brainmatters-996	146	2	2023	2023	NUM
brainmatters-996	146	3	,	,	PUNCT
brainmatters-996	146	4	june	june	PROPN
brainmatters-996	146	5	27	27	NUM
brainmatters-996	146	6	)	)	PUNCT
brainmatters-996	146	7	.	.	PUNCT
brainmatters-996	147	1	nuffield	nuffield	PROPN
brainmatters-996	147	2	trust	trust	PROPN
brainmatters-996	147	3	.	.	PUNCT
brainmatters-996	148	1	https://www.nuffieldtrust.org.uk/resource/cancersurvival-rates	https://www.nuffieldtrust.org.uk/resource/cancersurvival-rates	PROPN
brainmatters-996	148	2	4	4	NUM
brainmatters-996	148	3	.	.	PUNCT
brainmatters-996	149	1	expanding	expand	VERB
brainmatters-996	149	2	the	the	DET
brainmatters-996	149	3	disease	disease	NOUN
brainmatters-996	149	4	network	network	NOUN
brainmatters-996	149	5	of	of	ADP
brainmatters-996	149	6	glioblastoma	glioblastoma	NOUN
brainmatters-996	149	7	multiforme	multiforme	NOUN
brainmatters-996	149	8	via	via	ADP
brainmatters-996	149	9	topological	topological	ADJ
brainmatters-996	149	10	analysis	analysis	NOUN
brainmatters-996	149	11	.	.	PUNCT
brainmatters-996	150	1	(	(	PUNCT
brainmatters-996	150	2	2023	2023	NUM
brainmatters-996	150	3	,	,	PUNCT
brainmatters-996	150	4	february	february	PROPN
brainmatters-996	150	5	4	4	NUM
brainmatters-996	150	6	)	)	PUNCT
brainmatters-996	150	7	.	.	PUNCT
brainmatters-996	151	1	ncbi	ncbi	NOUN
brainmatters-996	151	2	.	.	PUNCT
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brainmatters-996	152	3	.	.	PUNCT
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brainmatters-996	153	5	.	.	PUNCT
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brainmatters-996	154	4	.	.	PUNCT
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brainmatters-996	155	4	.	.	PUNCT
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brainmatters-996	156	3	–	–	PUNCT
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brainmatters-996	156	5	,	,	PUNCT
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brainmatters-996	156	10	.	.	PUNCT
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brainmatters-996	157	4	)	)	PUNCT
brainmatters-996	157	5	.	.	PUNCT
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brainmatters-996	158	6	.	.	PUNCT
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brainmatters-996	159	2	.	.	NOUN
brainmatters-996	159	3	7	7	X
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brainmatters-996	159	9	,	,	PUNCT
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brainmatters-996	160	4	)	)	PUNCT
brainmatters-996	160	5	.	.	PUNCT
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brainmatters-996	161	6	.	.	PUNCT
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brainmatters-996	162	3	.	.	PUNCT
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brainmatters-996	164	3	,	,	PUNCT
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brainmatters-996	164	7	.	.	PUNCT
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brainmatters-996	165	6	.	.	PUNCT
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brainmatters-996	166	3	.	.	PUNCT
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brainmatters-996	166	7	,	,	PUNCT
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brainmatters-996	166	14	,	,	PUNCT
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brainmatters-996	166	18	.	.	PUNCT
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brainmatters-996	167	15	.	.	PUNCT
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brainmatters-996	168	2	health	health	PROPN
brainmatters-996	168	3	.	.	PUNCT
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brainmatters-996	169	2	10	10	NUM
brainmatters-996	169	3	.	.	PUNCT
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brainmatters-996	170	7	.	.	PUNCT
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brainmatters-996	171	3	,	,	PUNCT
brainmatters-996	171	4	may	may	AUX
brainmatters-996	171	5	20	20	NUM
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brainmatters-996	171	7	.	.	PUNCT
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brainmatters-996	172	2	.	.	PUNCT
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brainmatters-996	173	3	.	.	PUNCT
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brainmatters-996	174	5	.	.	PUNCT
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brainmatters-996	175	3	,	,	PUNCT
brainmatters-996	175	4	may	may	AUX
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brainmatters-996	175	7	.	.	PUNCT
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brainmatters-996	176	2	.	.	PUNCT
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brainmatters-996	177	3	.	.	PUNCT
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brainmatters-996	178	15	.	.	PUNCT
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brainmatters-996	179	18	.	.	PUNCT
brainmatters-996	180	1	ncbi	ncbi	NOUN
brainmatters-996	180	2	.	.	PUNCT
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brainmatters-996	181	2	13	13	NUM
brainmatters-996	181	3	.	.	PUNCT
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brainmatters-996	181	14	(	(	PUNCT
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brainmatters-996	181	17	.	.	PUNCT
brainmatters-996	182	1	(	(	PUNCT
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brainmatters-996	182	3	.	.	PROPN
brainmatters-996	182	4	)	)	PUNCT
brainmatters-996	182	5	.	.	PUNCT
brainmatters-996	183	1	mdpi	mdpi	PROPN
brainmatters-996	183	2	.	.	PUNCT
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brainmatters-996	185	1	https://www.insideprecisionmedicine.com/topics/oncology/why-glioblastoma-does-not-respond-to-immunotherapy-but-other-brain-cancers-do/	https://www.insideprecisionmedicine.com/topics/oncology/why-glioblastoma-does-not-respond-to-immunotherapy-but-other-brain-cancers-do/	PRON
brainmatters-996	185	2	https://www.nuffieldtrust.org.uk/resource/cancer-survival-rates	https://www.nuffieldtrust.org.uk/resource/cancer-survival-rate	VERB
brainmatters-996	185	3	https://www.moffitt.org/cancers/glioblastoma/diagnosis/causes/	https://www.moffitt.org/cancers/glioblastoma/diagnosis/causes/	PROPN
brainmatters-996	185	4	https://www.uclahealth.org/news/why-certain-brain-tumors-dont-respond-to-immunotherapy	https://www.uclahealth.org/news/why-certain-brain-tumors-dont-respond-to-immunotherapy	PROPN
brainmatters-996	185	5	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3278036/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3278036/	PROPN
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