1 Volume 24 2025 e257209 Original Research Braz J Oral Sci. 2025;24:e257209http://dx.doi.org/10.20396/bjos.v24i00.8677209 1 Multiprofessional Residency Program in Adult and Elderly Health, University Hospital of Sergipe, Federal University of Sergipe (UFS), Aracaju, Sergipe, Brazil. 2 Dental Outpatient Clinic, Brazilian Hospital Services Company (EBSERH), University Hospital of Sergipe, Federal University of Sergipe, Aracaju, Sergipe, Brazil. 3 Department of Dentistry, University Hospital of Sergipe, Federal University of Sergipe, Aracaju, Sergipe, Brazil. 4 Oncology and Hematology Service, Brazilian Hospital Services Company, University Hospital of Sergipe, Federal University of Sergipe, Aracaju, Sergipe, Brazil. Corresponding author: Iandra Luah Souza Maia Ambulatório de Odontologia, Hospital Universitário, Universidade Federal de Sergipe. Rua Cláudio Batista, SN, Palestina, Aracaju, Sergipe, Brasil. CEP: 49060-025. Telefone: +55 79 2105-1700 Ramal: 1797 Email: Iandralsm.odonto@gmail.com Editor: Dr. Altair A. Del Bel Cury Received: July 15, 2024 Accepted: March 04, 2025 Oral manifestations in patients undergoing chemotherapy Iandra Luah Souza Maia1* , Rosany Larissa Brito de Oliveira1,2 , Luiz Fernando Andrade Matos1 , Antônio Carlos Marqueti1,3 , Geydson Silveira da Cruz4 , Álvaro Bezerra Cardoso1,2 The proposed treatment for malignant neoplasms can be isolated or combined, involving resective surgery, radiotherapy, chemotherapy, and/or hormone replacement. Chemotherapy induces extensive immunosuppression and affects both healthy and abnormal cells. This cytotoxicity from the treatment has a significant effect that can lead to changes in the oral mucosa. The severity is related to the type of drug, duration of treatment, dosage used, level of oral hygiene during treatment, and the individual’s age. Therefore, monitoring oral health before, during, and after antineoplastic therapy is essential. Aim: To evaluate the main oral manifestations that oncology patients presented before and after 15 days from the first administration of chemotherapy medication. Methods: A prospective observational study was conducted with 31 individuals treated at a Hospital Oncology and Hematology Service. The evaluations included the following steps: (1) Patient identification and completion of assessment forms; (2) Clinical examination of the oral cavity before and after the start of chemotherapy; and (3) Providing guidance to patients regarding oral care during oncological treatment. Results: It was observed that 70.96% of patients exhibited oral manifestations 15 days after the first infusion of antineoplastic drugs. The main changes identified included xerostomia and oral mucositis. Conclusion: Dental follow-up during chemotherapy is essential for preventing and managing potential oral emergencies, thereby avoiding interruptions in systemic treatment and ultimately enhancing the quality of life for these patients. Keywords: Dentistry. Medical oncology. Antineoplastic agents. Oral manifestations. https://orcid.org/0000-0002-0587-0940 https://orcid.org/0000-0001-8782-7585 https://orcid.org/0000-0003-4583-0449 https://orcid.org/0000-0002-6704-9269 https://orcid.org/0000-0001-9392-0321 https://orcid.org/0000-0002-6725-1547 2 Maia et al. Braz J Oral Sci. 2025;24:e257209 Introduction Cancer, in most countries, ranks among the top four causes of death before the age of 70. Changes in cancer types are observed in developing countries, with a decrease in infection-related types and an increase in carcinomas associated with improved socioeconomic conditions and the adoption of harmful habits such as poor diet, sed- entary lifestyle, and stress1. In Brazil, the estimated number of new cancer cases between 2020 and 2022 was 625.000. The most prevalent carcinomas were skin (non-melanoma), followed by breast, prostate, colon, and rectum. In the state of Sergipe, it was estimated that 5.950 new cases would be registered annually, with the highest incidence in prostate and breast carcinomas2. Therefore, malignant neoplasms constitute a significant societal issue. It is crucial to prioritize early diagnosis, control, and cancer prevention as strat- egies for public health3,4. Carcinogenesis is characterized by the uncontrolled and excessive proliferation of cells, resulting in loss of cellular differentiation. This cellular disorder is caused by numerous factors, including genetic, environmental, and epigenetic alterations5. The primary treatment for cancer is chemotherapy, which induces extensive immuno- suppression and affects both healthy and abnormal cells6. However, healthy cells have a recovery period lasting from 5 to 15 days, while neoplastic cells are disor- ganized and do not recover. Therefore, chemotherapy treatment is administered in periodic cycles7. The cytotoxicity of the treatment can lead to oral lesions, and the severity is related to the type and degree of malignancy, the duration of chemotherapy treatment, and the dosage used. The individual’s age and the level of oral hygiene should also be considered3,7. The oral mucosa is more affected due to its similarity in tissue renewal rate compared to the uncontrolled proliferation of neoplastic cells8. Regarding antineoplastic therapy, some chemotherapeutic agents are more stomato- toxic than others. Drugs like 5-fluorouracil, methotrexate, and cyclophosphamide are among those most associated with oral lesions6. Around 40% of patients treated with chemotherapy experience oral manifestations due to direct or indirect toxicity, with mucositis, xerostomia, and viral and fungal infections being the main issues7. These manifestations can cause severe pain, difficulty in nutrition, and sepsis, potentially leading to temporary cessation of chemotherapy and increased hospitalization peri- ods. This contributes to patient treatment discontinuation. Therefore, it is essential to have a dentist as part of the multidisciplinary team in oncological treatment. There- fore, a protocol is necessary that involves oral environment management, removal of infection foci, oral hygiene guidance, early diagnosis, and treatment of manifestations caused by antineoplastic medications6,9. The present study aimed to evaluate the main oral manifestations and dental needs among oncology patients at the Oncology and Hematology Service of the University Hospital of Sergipe (HU-UFS). Additionally, it aimed to validate the importance of the dentist in monitoring patients before, during, and after chemotherapy treatment. 3 Maia et al. Braz J Oral Sci. 2025;24:e257209 Material and Methods This study was approved by the Research Ethics Committee of the Federal Uni- versity of Sergipe under protocol number 5.270.225 and Certificate of Ethical Appreciation Presentation number 52125521.3.0000.5546. It was a case series study, observational, prospective, longitudinal, utilizing technical resources of quantitative approach. The sample included individuals using chemotherapy medications, aged 18 years and older, without distinction of gender, race, group, or social class, treated at the Oncology and Hematology Service of HU-UFS between January and May 2022. Volun- teers included in the study were informed about each phase and subsequently signed the Informed Consent Form. Individuals lacking perceptual-cognitive conditions to respond to inquiries were excluded from the study. The patients were evaluated at two time points: 1) before the administration of chemotherapy and 2) 15 days after the first chemotherapy infusion. The evaluation consisted of two stages: 1) patient identification and medical history and 2) clinical examination of the oral cavity. The oral cavity examination was conducted by a sin- gle evaluating dentist, who assessed eleven anatomical sites: perioral region, right and left labial commissure, upper and lower lips, right and left buccal mucosa, ves- tibular sulcus, dorsum of the tongue, ventral surface of the tongue, tongue margin, hard palate, soft palate, and gingiva. The changes found in the anatomical sites were recorded on a pre-designed evalua- tion form. When oral mucositis was identified, it was classified according to the scale recommended by the WHO. All identified lesions were appropriately treated. Informa- tion regarding the antineoplastic therapy (chemotherapy, dose, cycle, etc.) was also recorded on the evaluation form. It was also observed whether the patient had any need for oral environment adjust- ment, such as periodontal scaling, restorations, elimination of septic foci, smoothing of sharp dental edges, complaints of xerostomia, and dry lips. When dental treatment was necessary, patients were referred to the Dental Outpatient Clinic at HU-UFS. At the end of the assessment, all patients were provided with an informative leaflet containing oral care guidelines for oncology patients. The results obtained in this research were subjected to descriptive analysis and pre- sented in tables, showing both absolute values and percentages. Results Table 1 presented the demographic data of the research participants. Out of 31 par- ticipants, 20 (64.5%) were female and 11 (35.5%) were male, with a mean age of 55.6 years. The majority of participants identified as mixed race (83.9%), were native to the interior of the state (67.7%), had completed high school education (58.0%), and were married (54.8%). 4 Maia et al. Braz J Oral Sci. 2025;24:e257209 Table 1. Sociodemographic Characteristics of Individuals Undergoing Chemotherapy Treatment. Mean + SD 55.6 + 14.4 Age N % Sex Female 20 64.5 Male 11 35.5 Race White 4 12.8 Mixed race (Brown) 26 83.9 Black 1 3.3 Place of Birth Capital 10 32.3 Interior 21 67.7 Educational Level Illiterate 2 6.5 Elementary School 9 29.0 High School 18 58.0 Higher Education 2 6.5 Marital Status Single 10 32.3 Married 17 54.8 Widowed 1 3.2 Divorced 3 9.7 Total 31 100.0 Dental needs present before the start of chemotherapy treatment can be seen in Table 2. Among the dental demands observed were: 7 patients needing restorative pro- cedures, 8 needing tooth extractions, and 16 needing periodontal treatment. A signif- icant number of patients with tooth loss were identified, with those using old and/or ill-fitting dentures or without dentures being referred for prosthetic rehabilitation. Table 2. Distribution of dental needs before the start of chemotherapy treatment. Number of teeth with caries lesions Number of residual roots Number of sextants with dental calculus Number of missing teeth 1 0 0 6 9 2 2 0 0 30 3 0 0 0 5 Continue 5 Maia et al. Braz J Oral Sci. 2025;24:e257209 Continuation 4 0 0 0 32 5 1 0 0 6 6 0 0 0 27 7 0 1 6 9 8 0 0 1 12 9 2 0 0 25 10 2 4 5 5 11 0 0 0 7 12 0 0 1 27 13 0 1 0 0 14 0 1 2 5 15 1 1 2 4 16 0 0 0 0 17 0 0 2 3 18 0 0 0 32 19 1 0 0 3 20 0 1 2 4 21 0 0 2 7 22 1 0 2 4 23 0 1 0 27 24 0 0 0 22 25 0 0 0 32 26 0 0 1 14 27 0 0 0 32 28 0 0 1 25 29 0 0 1 24 30 0 2 2 5 31 0 0 2 3 Regarding the location of malignant neoplasms (Table 3), the most frequent sites were: breast (9), lymphatic tissue (4), and lung (3). Among the medication protocols for antineoplastic therapy, the most commonly used drug was paclitaxel 11 (35.48%), followed by carboplatin 6 (19.35%). Regarding oral manifestations, after the first medication administration among the 31 patients (Table 3), 22 reported some type of discomfort in the oral cavity. The majority of patients presented with xerostomia (9 cases - 29.03%), followed by oral mucositis (MO) (6 cases - 19.35%) and candidiasis (5 - 16.13%). Additionally, other oral changes were also observed, such as dysgeusia, odynophagia, and lesions caused by herpes simplex virus. 6 Maia et al. Braz J Oral Sci. 2025;24:e257209 Table 3. Distribution of individuals undergoing chemotherapy treatment and oral manifestations. Localization Chemotherapy Oral manifestations at initial evaluation Oral manifestations after chemotherapy began 1 Cervix Cisplatin No manifestations Xerostomia and Dysgeusia 2 Left breast Paclitaxel + Doxorubicin + Cyclophosphamide No manifestations Dry lips 3 Hematopoietic tissue Doxorubicin + Tretinoin No manifestations Grade III Mucositis, Odynophagia, and Pseudomembranous Oral Candidiasis 4 Pancreas Gemcitabine + capecitabine No manifestations No manifestations 5 Right breast Paclitaxel + trastuzumab No manifestations Dysgeusia and Xerostomia 6 Left breast Paclitaxel + carboplatin No manifestations No manifestations 7 Cervix Cisplatin No manifestations No manifestations 8 Right breast Paclitaxel No manifestations No manifestations 9 Left breast Paclitaxel Erythematous oral candidiasis Erythematous oral candidiasis 10 Prostate Docetaxel + zoledronic acid Traumatic ulcer on lower lip Dry lips and xerostomia 11 Lymphatic tissue ABVD (Doxorubicin + bleomycin + vinblastine + dacarbazine)) No manifestations No manifestations 12 Right breast Paclitaxel No manifestations Xerostomia; Dysgeusia; petechiae on the right buccal mucosa 13 Ascending colon and cecum Capecitabine No manifestations Grade III mucositis 14 Hematopoietic tissue Doxorubicin + cytarabine Angular cheilitis and dry lips Petechiae on oral mucosa, Odynophagia, Grade III mucositis 15 Lung Carboplatin + paclitaxel No manifestations Dry lips, Generalized pseudomembranous oral candidiasis, Oral burning sensation, Xerostomia 16 Head and neck Carboplatin+ paclitaxel No manifestations Xerostomia and tooth sensitivity 17 Middle rectum FLOX (Oxaliplatin + Calcium folinate + Fluorouracil) No manifestations Pseudomembranous oral candidiasis, Grade II mucositis, and dry, crusty lips 18 Lung Paclitaxel + carboplatin No manifestations Grade I mucositis 19 Prostate Docetaxel + prednisone + zoledronic acid No manifestations No manifestations 20 Right breast Doxorubicin + Cyclophosphamide + filgrastim No manifestations Dry lips with ulcerations and Grade III mucositis 21 Ovaries Carboplatin + paclitaxel No manifestations Xerostomia Continue 7 Maia et al. Braz J Oral Sci. 2025;24:e257209 Continuation 22 Bile ducts Gemcitabine + Cisplatin Actinic cheilitis on the lower lip Lesion caused by herpes simplex virus and actinic cheilitis on lower lip 23 Stomach FLOX (Oxaliplatin + Calcium folinate + Fluorouracil) No manifestations Dry lips and xerostomia 24 Right breast Doxorubicin + Cyclophosphamide No manifestations Traumatic ulcer and sialorrhea 25 Lymphatic tissue R-CHOP (rituximab + Cyclophosphamide + Doxorubicin + vincristine + prednisone)) Actinic cheilitis on the lower lip and petechiae on the dorsal surface of the tongue Actinic cheilitis on lower lip and herpes simplex virus on hard palate 26 Lymphatic tissue ABVD (Doxorubicin + bleomycin + vinblastine + dacarbazine) No manifestations Dysgeusia and xerostomia 27 Colon FLOX (Oxaliplatin + Calcium folinate + Fluorouracil) No manifestations No manifestations 28 Stomach FLOX (Oxaliplatin + Calcium folinate + Fluorouracil) Dry lips and hemangioma on buccal mucosa Hemangioma on buccal mucosa 29 Lung Carboplatin + paclitaxel Dry lips and erythematous oral candidiasis Erythematous oral candidiasis 30 Right and left breast Doxorubicin + cyclophosphamide No manifestations Xerostomia 31 Lymphatic tissue ABVD (Doxorubicin + bleomycin + vinblastine + dacarbazine) No manifestations No manifestations Discussion The best time to plan and implement dental treatment is before the patient starts oncologic therapy, whether chemotherapy or radiation therapy. The cornerstone of dental care for patients with malignant neoplasms focuses on promoting oral health, which includes preventive measures such as oral hygiene instructions, as well as ther- apeutic care for conditions like mucositis, xerostomia, oral infections, among others. Additionally, it’s crucial to eliminate potential sources of oral trauma, such as remov- ing orthodontic appliances, adjusting poorly fitting dentures, and extracting fractured teeth10,11. This approach allows for not only prevention but also immediate treatment of oral manifestations that may arise during oncologic therapy. This helps prevent systemic complications, promotes treatment progress, and improves the prognosis for oncology patients11-13. In the study by Dholam et al.13 (2021), the oral health of patients undergoing neo- adjuvant chemotherapy for head and neck cancer was analyzed. Participants were evaluated during the pre-, trans-, and post-chemotherapy periods. At the end of the study, 130 patients completed all three evaluations. Among them, 23 participants underwent restorative treatment, and 119 extractions were performed during the pre-chemotherapy period. These findings align with the results of the current research, 8 Maia et al. Braz J Oral Sci. 2025;24:e257209 highlighting that the primary dental treatments performed included periodontal treat- ment, dental extractions, and restorative treatment. In the study conducted by Hespanhol et al.6 (2010), it was observed that oral changes were the most frequent adverse reactions resulting from antineoplastic treatment. The most common incidents were xerostomia, oral mucositis, and bacterial, viral, or fungal infections. These adverse reactions stem from the cytotoxic effects of chemotherapy drugs, which can lead to direct stomatotoxicity reactions such as mucositis, hyposalivation, dysgeusia, and neurotoxicity, or indirect stomatotoxicity reactions such as oral bleeding and opportunistic infections. In the study by Fernandes and Fraga14 (2019), oral manifestations during oncologic treatment were evaluated in 20 patients diagnosed with head and neck cancer. Treatment included chemotherapy combined with radiotherapy (70% of patients) and radiotherapy alone (30%). The most prevalent oral changes were xerostomia (100% of patients), oral mucositis (80%), oral candidiasis (80%), osteoradionecrosis (20%), and radiation caries (10%). These findings are similar to those reported by García-Chías et al.15 (2019) and Mercadante et al.16 (2015). In the present study, xerostomia was also the most observed oral manifestation; how- ever, it affected fewer individuals compared to the previously mentioned studies. This could be related to the type of oncologic treatment administered, as in this study, only chemotherapy was used, and patients undergoing head and neck radiotherapy were excluded. Additionally, the duration of chemotherapy treatment exposure may have influenced this result, as only manifestations occurring after 15 days from the first drug administration were considered in this study. Silva et al.12 (2021) investigated the association between xerostomia and taste alter- ation in patients undergoing chemotherapy, following 55 patients through the first two cycles of chemotherapy infusion. It was observed that taste alteration was sig- nificantly more prevalent in patients who reported xerostomia compared to those who did not. The study concluded that taste changes were more severe for patients expe- riencing xerostomia, and the combination of both symptoms potentially impacted the nutritional status and quality of life of the patients. In our study, 66.6% of patients who reported xerostomia also reported dysgeusia, which is consistent with findings from previous studies reporting a decrease in sub- jective taste function during the initial cycles of chemotherapy and recovery months after treatment completion17,18. Another oral manifestation highlighted in our study was oral mucositis, which affected 19.35% of patients, a percentage similar to findings in the literature. According to some studies, this complication occurs in up to 100% of patients receiving radiation therapy in the head and neck region and between 20 and 40% in those receiving conventional chemotherapy alone3,15. Dentists should be atten- tive to managing this complication, as the main issues include pain, loss of nutri- tional intake, and secondary infections19. These factors can lead to suspension of antineoplastic therapy, prolonged hospitalizations, and reduced quality of life for these individuals20,21. 9 Maia et al. Braz J Oral Sci. 2025;24:e257209 In the present study, the most commonly used drugs were paclitaxel and carbo- platin. Among the patients who experienced some degree of oral mucositis (MO) were those using drugs such as capecitabine, doxorubicin, fluorouracil, and pacli- taxel. These findings are consistent with the literature, which notes that chemother- apeutic agents posing a higher risk for the development of MO include bleomycin, capecitabine, cyclophosphamide, cytarabine, cisplatin, dactinomycin, docetaxel, doxorubicin, fluorouracil, methotrexate, and paclitaxel6,22-24. It is worth noting that, although no cases of Medication-Related Osteonecrosis of the Jaw (MRONJ) were observed in the present study, certain drugs used in the oncological therapy of some patients in this study, such as zoledronic acid and pred- nisone, are associated with MRONJ, according to the American Association of Oral and Maxillofacial Surgeons25. Although rare, MRONJ is a serious adverse effect due to the extensive morbidity it can cause and the poorer prognosis that oncology patients face when affected by it26,27. Therefore, the dentist needs to closely monitor these patients, intensify oral hygiene care, eliminate risk factors, and promote oral health maintenance to prevent the occurrence of MRONJ27. In conclusion, the main dental treatment needs observed before starting chemother- apy were periodontal treatment, tooth extractions, and restorative procedures. After 15 days from the first administration of antineoplastic drugs, oral manifestations may already occur. Out of the 31 individuals observed, 70.96% experienced some type of discomfort in the oral cavity, with xerostomia and oral mucositis being the most fre- quent. Additionally, other oral alterations were also observed, such as oral candidiasis, dry lips, and lesions caused by the herpes simplex virus. Dental monitoring during chemotherapy is essential for preventing and managing potential oral emergencies, thereby preventing interruptions in systemic treatment and ultimately improving the quality of life for these patients. Data availability Datasets related to this article will be available upon request to the corresponding author. Conflicts of interest The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript. Acknowledgements The authors report no acknowledgments for this research. Author Contribution Iandra Luah Souza Maia: Conceptualization; Data curation; Investigation; Methodology; Formal analysis; Writing - original draft. Rosany Larissa Brito de Oliveira: Conceptualization; Methodology; Writing - original draft; Writing - review & editing; Supervision; Project administration. Luiz Fernando Andrade Matos: Visualization; 10 Maia et al. Braz J Oral Sci. 2025;24:e257209 Writing - original draft; Writing - review & editing. Antônio Carlos Marqueti: Validation; Resources; Writing - review & editing. Geydson Silveira da Cruz: Validation; Resources; Writing - review & editing. Álvaro Bezerra Cardoso: Conceptualization; Methodology; Writing - original draft; Writing - review & editing; Supervision; Project administration. All authors actively participated in the manuscript’s findings, revised, and approved the final version of the manuscript. References 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Erratum in: CA Cancer J Clin. 2020 Jul;70(4):313. doi: 10.3322/caac.21609. 2. INCA. Brazilian National Cancer Institute. [Estimate 2020: cancer incidence in Brazil.] Rio de Janeiro: INCA; 2019 [cited 2023 Apr 13]. 120p. 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