id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
caryologia-1041	Asita, Asita Okorie; Magama, Sibusisiwe; Moahloli, Thato Mamoroesi; Baholo , Selometsi	Evaluation of extracts of wild Cannabis sativa L. for genotoxicity and phytochemical composition	2021	16	.pdf	application/pdf	11155	600	57	2.8.3 Modulatory effect (ME) of plant extracts on muta- gen-induced genotoxicity The modulatory effect (ME) of plant extract on CP- or EMS-induced genotoxicity (GT) was calculated using the formula of Asita et al. (2017): ME = (B – C) – (A – C) / (A – C) (4) Where ‘A’ is the genotoxicity induced by the muta- gen (CP or EMS) alone, i.e. mutagen-induced genotoxic- ity; ‘B’ is the genotoxicity induced by mixture of plant extract and mutagen, i.e. mixture-induced genotoxicity and ‘C’ is the genotoxicity induced by negative control, such as tap water alone. From the results of the preliminary assays to select the concentrations of mutagens and plant extracts to use, the following concentrations of plant extracts (in mgmL-1); methanol extract (0.75, 1.5 and 3.00) and ethyl acetate extracts (0.750, 0.375, 0.1875 and 0.09375); CP (1.25.00) and EMS (0.250) were assessed for cytotoxicity that is, mitotic index (MI), genotoxicity (GT) and the modulatory effect (ME) of plant extracts on mutagen-induced genotoxicity.	cache/caryologia-1041.pdf	txt/caryologia-1041.txt