id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-287349-1zcq7kzx	Chen, James	Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex	2020-07-28		.txt	text/plain	2970	76	27	In Family Coronaviridae Crystal structure of Middle East respiratory syndrome coronavirus helicase From SARS to MERS: 10 years of research on highly 1162 pathogenic human coronaviruses Structure 1165 of replicating SARS-CoV-2 polymerase Dali server update Human Coronavirus 229E Nonstructural Protein 13: 1170 Characterization of Duplex-Unwinding, Nucleoside Triphosphatase, and RNA 5′-Triphosphatase Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus Helicase Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus 1179 Nsp13 upon ATP hydrolysis Structural basis of transcription arrest by coliphage HK022 nun in an 1183 DnaB Drives DNA Branch Migration and Dislodges 1186 Structure of the SARS-CoV nsp12 polymerase bound 1192 to nsp7 and nsp8 co-factors Transcriptional arrest: Escherichia coli RNA 1195 polymerase translocates backward, leaving the 3' end of the RNA intact and extruded RNA polymerase switches between inactivated and 1200 activated states By translocating back and forth along the DNA and the RNA Molecular Evolution of Multisubunit RNA Polymerases: 1204 Structural Analysis Cooperative 1207 translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13 Discovery of an essential nucleotidylating activity associated with a newly delineated conserved 1213 domain in the RNA polymerase-containing protein of all nidoviruses What we know but 1217 do not understand about nidovirus helicases The EMBL-EBI search and sequence analysis tools APIs in 1221 2019 Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to 1229 polydisperse ensembles Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in 1233 coronavirus RNA synthesis Collaboration gets the most out of software Discovery of the first insect nidovirus, a missing evolutionary 1240 link in the emergence of the largest RNA virus genomes Cell the register of transcription by preventing backtracking of RNA polymerase Structure 1252 and function of the transcription elongation factor GreB bound to bacterial RNA polymerase Sequence 1256 requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA 1257 synthesis Analyzing resistance to 1264 design selective chemical inhibitors for AAA proteins cryoSPARC: algorithms for 1267 rapid unsupervised cryo-EM structure determination High-Throughput Deconvolution of Native Mass Spectra A 1274 planarian nidovirus expands the limits of RNA genome size Mechanistic basis of 1277 5'-3' translocation in SF1B helicases Advances in Experimental Medicine and Biology RELION: implementation of a Bayesian approach to cryo-EM structure 1283 determination Sequence logos: a new way to display consensus 1286 sequences Biochemical Characterization 1289 of the Equine Arteritis Virus Helicase Suggests a Close Functional The human coronavirus 229E superfamily 1 helicase has RNA and DNA duplex-unwinding activities with 5′-to-3′ polarity Remdesivir and SARS-CoV-2: structural requirements at 1302 both nsp12 RdRp and nsp14 Exonuclease active-sites Structure and Mechanism of 1305 Helicases and Nucleic Acid Translocases Coronaviruses lacking exoribonuclease 1308 activity are susceptible to lethal mutagenesis: evidence for proofreading and potential 1309 therapeutics Thinking Outside the Triangle: Replication Coronavirus RNA Synthesis and Processing Continuous and Discontinuous RNA 1318 Synthesis in Coronaviruses Protein AMPylation by an Evolutionarily Conserved 1322 One severe acute respiratory syndrome 1326 coronavirus protein complex integrates processive RNA polymerase and exonuclease activities The Severe Acute Respiratory Syndrome (SARS) In this case backtracking is energetically disfavored since it only 291 shortens the product RNA duplex without recovering duplex nucleic acids somewhere else.	cache/cord-287349-1zcq7kzx.txt	txt/cord-287349-1zcq7kzx.txt
