id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cajgh-231	Valente, Andre X.C.N.; Adilbayeva, Altynai; Tokay, Tursonjan; Rizvanov, Albert	The Universal Non-Neuronal Nature of Parkinson's Disease: A Theory	2016	12	.pdf	application/pdf	7127	481	51	In terms of global gene expression in hematopoietic stem cells (HSCs), nitric oxide mediated signal transduction, the NF-kB cascade and the pro-inflammatory response are the most age up-regulated processes, while chromatin silencing, single-strand break repair, SMAD protein nuclear translocation and chromatin remodeling are the most down-regulated ones.56 Alterations at the HSC epigenetic level are supported by many chromosomal regions showing a coordinated change in transcriptional activity.56 Fate-wise, a skewing to the myeloid line and a diminished lymphoid potential are observed with ageing.57 It has been known for a long time that reactive oxygen species (ROS), if not properly checked, have the potential to cause indiscriminate cellular damage.30 Today, it is recognized that ROS may also play a functional signaling role in activating processes such as the inflammatory and stress responses.28,58 Additionally, there is indication that ROS play a role in regulating hematopoiesis.59 In particular, evidence associates abnormal ROS levels at old age with a dysfunction in both the proliferation and the differentiation dynamics of HSCs. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.	cache/cajgh-231.pdf	txt/cajgh-231.txt