id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cajgh-29	Akilzhanova, Ainur R.; Nyshanbekkyzy, Bagdat; Nurkina, Zhannur M.; Shtephanov, Ivan I.; Makishev, Abay K.; Adylkhanov, Tasbolat A.; Rakhypbekov, Tolebay K.; Ramanculov, Erlan M.; Momynaliev, Kuvat T.	BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan.	2013		.htm	text/html	7445	402	60	The frequency of BRCA1 mutations in Chinese women with breast cancer without family history was 5.4%.40 On the other hand, 2% of breast cancer cases in the largest breast cancer population-based study in a UK population showed association with BRCA genes with 0.7% attribution of BRCA1 (Anglian Breast Cancer Study Group, 2000).41 Several hospital-based series of unselected breast cancers implicate BRCA1 and BRCA2 in 2–5% and 0–2% of all cases, respectively.41 The two most common haplotypes, defined by the alleles Gln356Pro871Glu1038Ser1613 and Gln356Leu871Gly1038Gly1613, have frequencies of 0.57 and 0.32, respectively, and these frequencies do not differ significantly between patient and control groups, indicating that the most common polymorphisms of the BRCA1 gene do not make a significant contribution to breast or ovarian cancer risk.30 Common polymorphisms in BRCA1/2 genes appear to be highly prevalent in Kazakhstan breast cancer cases and in healthy controls which is in concordance with previously reported findings in some Asian and European populations.37-43, 47-49 Frequencies of these polymorphisms were higher in breast cancer cases vs controls, particularly in the BRCA2 gene, p<0.05.	cache/cajgh-29.htm	txt/cajgh-29.txt