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Pre-conception preparation at the 

antiphospholipid syndrome as way 

to improve reproductive health 

 

Gulyash Tanysheva, Saule 

Kabylova, Sholpan Kinayatova, 

Aizat Zhumazhanova 

 

Semey State Medical University, Semey, 

Kazakhstan

 

Vol. 2, Suppl. (2013)   |   ISSN 2166-7403 (online)    

DOI 10.5195/cajgh.2013.104   |   http://cajgh.pitt.edu 

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TANYSHEVA 

 

 

This work is licensed under a Creative Commons Attribution 3.0 United States License. 

 

This journal is published by the University Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 2, Suppl. (2013)  |  ISSN 2166-7403 (online)  |  DOI 10.5195/cajgh.2013.104  |  http://cajgh.pitt.edu 

  

 

Abstract 

Introduction: Reproductive health is characterized by the condition of the woman in association with the course of pregnancy 

and childbirth. In this case, the absence of disease plays a fundamental role. Unfortunately, conditions that can negatively impact 

reproductive health and cause deterioration of pregnancy and delivery outcomes are frequent in women of reproductive age. 

Antiphospholipid syndrome (APS) is one of the leading conditions that can negatively affect reproductive health and lead to 

various complications in pregnancy including fetal loss.   

 

Materials and methods: We assessed the effectiveness of pre-conception preparing, including traditional therapy of APS in 

conjunction with system enzyme therapy (SET) and plasmapheresis sessions. We conducted a study in two groups: women with 

APS and pre-conception preparing (n = 49) and the control group were women without pre-conception preparing (n = 46). 

 

Results: The effect of pre-conception preparing in women with APS was assessed by the course and outcome of pregnancy. The 

total number of women with complications of pregnancy were 39.1% lower in the study group compared to the control group. 

Risk of miscarriage in the basic group observed 68.7 % less frequently compared to the  control group. The frequency of pre-

eclampsia was 63.5 % less in the study group compared to the control group. We observed significantly lower rates of placental 

insufficiency in the study group and the difference in this parameter reached 65.2%. The risk of pre-term birth was 59.4 % lower 

in the study group compared to the control group.  

 

Conclusion: We concluded that pre-conception preparing in women with APS increases the possibility of physiological course 

pregnancy. Pre-conception preparing reduces the incidence of miscarriage, pre-term labor, and the development of pre-eclampsia, 

and placental insufficiency. 

Keywords: antiphospholipid syndrome, pre-conception 

 

 

 

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