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Randomized Clinical Trial: Efficacy 

of a New Synbiotic in Adults with 

Metabolic Syndrome 

 

Almagul Kushugulova1, Valerii 

Benberin2, Raushan Karabayeva2, 

Saule Saduakhasova1, Samat 

Kozhakhmetov1, Gulnara 

Shakhabayeva1, Indira 

Tynybayeva1, Talgat Nurgozhin1, 

Zhaxybay Zhumadilov1 

 
1Center for Life Sciences, Nazarbaev 

University, Astana, Kazakhstan  
2Medical Center of President's Affairs 
Administration of Republic of 
Kazakhstan, Astana, Kazakhstan 

 

Vol. 2, Suppl. (2013)   |   ISSN 2166-7403 (online)  

DOI 10.5195/cajgh.2013.111  |   http://cajgh.pitt.edu 

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KUSHUGULOVA 

 

 

This work is licensed under a Creative Commons Attribution 3.0 United States License. 

 

This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 2, Suppl. (2013) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2013.111 | http://cajgh.pitt.edu 

 

 

Abstract 

Introduction: Metabolic syndrome is a lifestyle disease and is a frequent problem among the adult population. Human gut 

microbiota plays a key role in the development of metabolic syndrome. Recently, the gut microbiota has emerged as an important 

contributor to the development of obesity and metabolic disorders through its interactions with environmental (e.g. diet) and 

genetic factors. The aim of this study was to research the effects of synbiotic on the gut microbiota and host metabolism. 

Methods: We conducted a double-blind, randomized, placebo-controlled trial. Our sample included 180 adults (ages 30-89) with 

symptoms of metabolic syndrome, who were allocated to either placebo or synbiotic group. The main inclusion criteria were: 

blood pressure of around 130/90 mmHg; raised fasting plasma glucose (FPG) >100 mg/dL (5.6 mmol/L), previous diagnosis of 

type 2 diabetes, dyslipidemia triglycerides (TG) of 1.70 mmol/L, a high-density lipoprotein cholesterol (HDL-C) of 0.90 mmol/L 

in males and 1.0 mmol/L in females, and central obesity with a waist/hip ratio > 0.90 in males or > 0.85 in females or a body 

mass index > 30 kg/m2. 

Results: We enrolled 90 adults in the placebo group and 90 in the synbiotic group. The two groups had similar demographic and 

clinical characteristics. Consent was signed by all patients. All patients underwent clinical and laboratory evaluation, including 

complete blood tests, glucose test, glycosylated  hemoglobin, total cholesterol and triglycerides, cholesterol, LDL, HDL plasma, 

immunogram, and coprogram. All patients were interviewed with a questionnaire that included 200 questions related to diet, 

lifestyle, and health. Synbiotic were used by patients in a dose of 200 grams twice a day. The duration of applying of the 

synbiotic was 90 days. 

To study the composition of the intestinal microbiota, stool samples were collected before and after applying the synbiotic. The 

microbial composition will be determined by analyzing the locus of 16S rDNA. 

Conclusion: This ongoing study is currently undergoing microbial composition analysis in order to establish the efficacy of the 

new synbiotic in adults with metabolic syndrome.   

Keywords: synbiotics, efficacy, metabolic syndrome 

 

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