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This journal is published by the University Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

 

 

 

 

 

 
 

 

 

 

 

Application of Cellular 

Technologies to the Experimental 

Treatment of Destructive 

Inflammatory Arthropathies 

 

Marzhan Kaulambayeva1, Galina 

Fedotovskikh2, Anara 

Nurmukhambetova1 

 
1RPE Antigen Ltd, Kazakhstan; 2National 
Research Medical Center, Astana, 
Kazakhstan 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Vol. 3, Suppl. (2014)   |   ISSN 2166-7403 (online)    

DOI 10.5195/cajgh.2014.161   |   http://cajgh.pitt.edu  

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KAULAMBAYEVA 

 

 

This work is licensed under a Creative Commons Attribution 4.0 United States License. 

 

This journal is published by the University Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 3, Suppl. (2014)  |  ISSN 2166-7403 (online)  |  DOI 10.5195/cajgh.2014.161  |  http://cajgh.pitt.edu 

  

 

Abstract 

Introduction. The treatment of destructive inflammatory joint diseases (arthropathies) is one of the issues of current interest in 

modern medicine. In destructive inflammatory diseases, the regenerative ability of cartilaginous tissue proves to be inadequate for 

neogenesis of joints. The goal of this study is to determine the efficacy of bone marrow-derived mononuclear cell fraction (MNC) 

and multipotent mesenchymal stromal cells (MMSC) in the treatment of destructive inflammatory joint diseases. 

Materials and methods. The study subjects consisted of 15 male rabbits weighing 3-4 kg with experimental destructive 

inflammatory knee joint disease. The test animals were divided into 3 groups: reference group without treatment, first test group – 

introduction of autologous MNC from rabbit bone marrow into the affected joint, and second test group – introduction of cultured 

MMSC from rabbit bone marrow into the joint. 

Results. A morphological examination of the synovial membranes in the reference group on the 40th day of the experiment revealed 

chronic synovitis with destruction of synoviocytes, thickening and inflammatory infiltration of the underlying connective tissue 

(subintima). During examination of synovial membranes in the first test group the patches of thickened regenerating inner layer 

(intima) made up by large proliferating synoviocytes were observed. The layer of loose connective tissue (subintima) contained a 

large number of small blood vessels and was only slightly infiltrated by inflammatory cells. The morphological examination of 

synovial membranes in the second test group discovered thickened regenerating intimal layer sitting on hypertrophied subintima 

with dense vascular network. Elastic collagenous layers of synovial membrane adjoined proliferating elements in cartilage plates. 

Conclusion. Both autologous MNC fraction and MMSC from bone marrow proved effectiveness in the treatment of destructive 

inflammatory joint diseases which stimulate neoangiogenesis. At the same time, it must be noted that the introduction of MMSC 

diminished destructive changes and accelerated proliferative process. 

Keywords: arthropathies, mononuclear cells, mesenchymal stromal cells, joint diseases 

 

 

 

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http://www.multitran.ru/c/m.exe?t=364176_1_2&s1=%F5%F0%FF%F9%E5%E2%E0%FF%20%F2%EA%E0%ED%FC

