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Therapeutic Potential of Noble 

Nanoparticles for Wound Repair 

 

Timur Saliyev1, Gulsim 

Kulsharova2, Alma Akhmetova1, 

Talgat Nurgozhin1, Sergey 

Mikhalovsky2,3 

 

1Center for Life Sciences, Nazarbayev 
University, Kazakhstan; 2School of 
Engineering, Nazarbayev University, 
Kazakhstan; 3School of Pharmacy and 
Biomedical Sciences, University of 
Brighton, UK 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Vol. 3, Suppl. (2014)   |   ISSN 2166-7403 (online)    

DOI 10.5195/cajgh.2014.172   |   http://cajgh.pitt.edu 

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SALIEV 

 

 

This work is licensed under a Creative Commons Attribution 4.0 United States License. 

 

This journal is published by the University Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 

Central Asian Journal of Global Health 

Volume 3, Suppl. (2014)  |  ISSN 2166-7403 (online)  |  DOI 10.5195/cajgh.2014.172  |  http://cajgh.pitt.edu 

  

 

Abstract 

Introduction. Nanoparticles made of noble metals, such as gold and silver, have a great potential to be effectively employed for 

wound management. The nano-size of such particles provides an opportunity to enlarge the contacting area, which results in more 

effective anti-bacterial action and faster wound repair. It must be noted that the shape of noble nanoparticles might play a crucial 

role in the manifestation of their anti-microbial properties. The modern state of technology allows fabrication of the nanoparticles 

with the desired shape and physical properties. In order to provide efficacy and close contact with the wound, the noble 

nanoparticles can be incorporated into a special matrix made of a cryogel (based on polymethyl methacrylate). This combination 

might serve as a foundation for developing completely new types of wound dressing. 

Materials and methods. We have developed a few methods for synthesizing gold and silver nanoparticles of different shapes and 

sizes. After fabrication of metallic nanoparticles, they were characterized by using Tunneling Electron Microscopy (TEM) and 

Malvern Zetasizer system in order to determine the average population size and consistency. The silver nanoparticles was 

synthesized using sodium borohydride reduction of silver nitrate. The synthesis of gold nanoparticles was conducted by using the 

Turkevich method.  

Results. We have developed a synthetic cryogel based on polyacrylamide (by cryogelation reaction) at several temperatures. At 

the second step, we developed a method for conjugating fabricated gold and silver nanoparticles to the surface (or pores) of cryogel 

through covalent bonds so they can provide antibacterial action within the wound. By following the developed protocol, we were 

able to obtain an approximate cryogel layer (1 cm thickness) with embedded gold and silver nanoparticles. This conjugate was 

analyzed and confirmed using Scanning Electron Microscopy (SEM) and TEM. 

Discussion. The obtained results indicate the feasibility of the fabrication of a novel type of wound dressing. At the next step, we 

are planning to elucidate the bio-compatibility of the combination of cryogel and nanoparticles. Moreover, anti-bacterial properties 

of this new type of wound dressing will be analyzed. 

Keywords: wound management, cryogel, nanoparticles, silver, gold 

 

 

 

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