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Association of rs2294008 and 
rs9297976 Polymorphisms in 
PSCA Gene with Gastric Cancer 
Susceptibility in Uzbekistan 
 

Shahlo Turdikulova1, Dilbar 
Dalimova1, Abror Abdurakhimov1, 
Bekzod Adilov1, Sarimbek 
Navruzov2, Abror Yusupbekov2, 
Mirjalol Djuraev2, Suleyman 
Abdujapparov2, Dilshod 
Egamberdiev2, Rustam 
Mukhamedov1 
 
1Institute of Bioorganic Chemistry 
Academy of Sciences Republic of 
Uzbekistan;  
2National Cancer Center of the Ministry 
of Health of the Republic of Uzbekistan 

 
Vol. 5, No. 1 (2016)   |   ISSN 2166-7403 (online)  
DOI 10.5195/cajgh.2016.227 |   http://cajgh.pitt.edu 

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Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Abstract 

Introduction: Genetic factors play an important role in the development of gastric cancer (GC), a prevalent malignancy in 
Central Asia. Recent studies have shown that single-nucleotide polymorphisms (SNPs) in several genes are associated with 
increased GC risk, indicating that genetic variation contributes to gastric carcinogenesis. Located on chromosome 8q24.2, the 
prostate stem cell antigen (PSCA) gene encodes a 123-amino acid glycoprotein related to the cell-proliferation inhibition and 
cell-death induction activity. SNPs in PSCA gene have been found to be associated with gastric cancer risk in a genome-wide 
association study, but results were not conclusive. This study aimed to investigate the association between two polymorphic 
variants of PSCA gene (rs2294008 and rs9297976) and the susceptibility to gastric cancer in Uzbekistan.  
Methods: Two hundred sixty eight patients with gastric cancer and a control group of 248 healthy individuals were included in 
this study. DNA samples isolated from these groups were genotyped using PCR-RFLP method. Comparative analysis of resulting 
genotypes showed a statistically significant association between CT genotype and gastric cancer (p=0.03, additive model of 
inheritance, Cochran-Armitage trend test). 
Results: Comparative analysis of the distribution of genotypes of rs2976392 polymorphism did not show a statistically 
significant difference; however, analysis of the distribution of the rs2976392 genotypes in a subgroup of young women revealed 
a statistically significant (p = 0.04, additive model of inheritance, Cochran-Armitage trend test) increase in the incidence of AA 
(38%) and AG (56%) genotypes in patients with GC, compared to the controls (20% and 40%). 
Conclusion: Our findings support that PSCA rs2294008 and rs9297976 polymorphism may contribute to the susceptibility to 
gastric cancer. Genotyping of these polymorphisms can potentially be recommended as one of the criteria for identification of 
high risk groups for gastric cancer development in Uzbekistan. 

Keywords: Gastric cancer, rs2294008, rs9297976, genotyping, Uzbekistan  

Association of rs2294008 and 
rs9297976 Polymorphisms in PSCA 
Gene with Gastric Cancer 
Susceptibility in Uzbekistan 

Shahlo Turdikulova1, Dilbar Dalimova1, 
Abror Abdurakhimov1, Bekzod Adilov1, 

Sarimbek Navruzov2, Abror 
Yusupbekov2, Mirjalol Djuraev2, 
Suleyman Abdujapparov2, Dilshod 
Egamberdiev2, Rustam Mukhamedov1 

 
1Institute of Bioorganic Chemistry Academy 
of Sciences Republic of Uzbekistan;   
2National Cancer Center of the Ministry of 
Health of the Republic of Uzbekistan 

Research 

Gastric cancer (GC) is the fifth most common 
cancer in the world, with 952,000 new cases diagnosed 
in 2012.1 Although the incidence of gastric cancer has 
declined in the general population in the US and in 
many countries around the world,2 it remains highly 
prevalent in Asia as compared to the West. The 
estimated rate of gastric cancer in Uzbekistan is 18.4% 
out of all cancer cases3 and GC remains a significant 
cause of cancer morbidity and mortality in Central Asia. 
Therefore, GC represents one of the key challenges in 
the development of cancer prevention and control 
strategy in Uzbekistan. 

Carcinogenesis is multi-stage process resulting 
from both exogenous factors (environmental and 
lifestyle) and endogenous factors (genetic, hormonal, 

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immune). In Asia, the prevalence of Helicobacter pylori 
(H. pylori) infection varies markedly in different 
countries, and is an important etiological factor for the 
occurrence of gastric adenocarcinoma.4 Previous study 
on the role of nutritional factors associated with GC in 
urban dwellers of Uzbekistan showed that the most 
important factors associated with this malignancy were 
intake of un-boiled water, artesian water, unrefined 
vegetable oil, margarine, animal fats, dietary salt, and 
daily consumption of meat-broth.5 The link between GC 
and water consumption may be explained by salt 
content in drinking water in some regions of 
Uzbekistan.6 Genetic factors also play an important role 
in the development of gastric cancer (GC). Previously 
published systematic review suggested that individuals 
who carry high-risk genetic variants and demonstrate 
particular dietary habits (such as high consumption of 
salty foods) may have an increased risk of gastric cancer 
compared with those who do not carry high-risk genetic 
variants.7 Recent studies have shown that single-
nucleotide polymorphisms (SNPs) in several genes are 
associated with increased GC risk, indicating that 
genetic variation contributes to gastric carcinogenesis.                  

The Prostate Stem Cell Antigen (PSCA) gene 
is located on chromosome 8q24.2 and encodes a 123-
amino acid cell surface protein with 30% homology to 
stem cell antigen type 2 (SCA-2).8 PSCA has been 
reported to be expressed mainly in differentiating cells 
rather than stem cells.9,10 PSCA belongs to the Thy-
1/Ly-6 family. Members of this family show a 
remarkable functional diversity ranging from T-cell 
activation to apoptosis regulation in the nervous 
system.11 PSCA is expressed in the epithelium of 
several organs, such as prostate, bladder, gallbladder, 
and stomach. In the gastric epithelium, the main 
expression sites are the isthmus and neck regions, which 
contain differentiating cells. The expression of PSCA is 
downregulated in the gastric tissue with intestinal 
metaplasia.9 

The first genome-wide association study 
(GWAS) on GC, performed in Japanese population, 
revealed an association between SNP rs2294008 of 
PSCA and risk of the diffuse type of GC. 
Substitution of C to T at rs2294008 in the first exon 
creates a novel translation start site (Met instead of Thr), 
which leads to the extension of the protein by 9 amino 
acids which changes the transcriptional activity of the 
gene.2 The association between rs2294008 and GC risk 
has been replicated in Caucasian and in some Asian 
populations.12-16 Two other SNPs (rs9297976 and 
rs12155758) were also discovered to be associated with 
GC in Europeans.13  

To date, an exploration of the association of the 
PSCA gene SNPs with GC has not been performed in 
the Central Asia populations. Uzbeks are the ideal group 
to investigate in this context, as they represent the 
largest and fastest growing population in Central Asia. 
Uniquely positioned on the route of the ancient Silk 
Road, the Uzbek population is a very interesting 
population to investigate in regard to its cultural, 
socioeconomic, and genetic diversity.  It is remarkable 
to note that Uzbek population has been formed by 
admixture of two or more ancestral populations, thus it 
offers a unique opportunity for studying the interaction 
between gene polymorphisms, ethnicity specific genetic 
factors, as well as environmental contributions to 
disease occurrence. 

The epidemiology of gastric cancer subtypes 
suggests there is a difference in the genetic background 
between Asian and Caucasian groups. For example 
“allele flip” between Asian and non-Asian groups is 
observed, most prominently in polymorphisms of IL-
1B and IL-10.17 In addition, an ethnic difference in 
terms of mutation frequency in MLH1 (an important 
gene for DNA mismatch repair that is associated with 
GC) between Eastern Asians and Western populations 
have been revealed.18 

The key aim of this research is to investigate 
the association between two polymorphic variants of 

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PSCA gene (rs2294008 and rs2976392) and link them 
to GC susceptibility in Uzbek populations.  

 

Methods 

Participants 

A total of 268 patients (168 males and 100 
females) with gastric cancer who underwent surgery in 
the Internal Medicine department at the National Cancer 
Center of the Ministry of Health of the Republic of 
Uzbekistan (NCC MoH UZB) and Tashkent Regional 
Oncological Dispensary, were recruited from 2011 to 
2013. All subjects were unrelated Uzbeks from 
Tashkent city and various regions of Uzbekistan. All 
cancer diagnoses were pathologically confirmed. 
Clinical data and pathological characteristics of patients 
were collected and confirmed from both their medical 
records and questionnaire data. The control group 
constituted of 248 healthy individuals (131 males and 
117 females) without a family history of gastric cancer. 
Cancer patients were recruited through Tashkent 
Regional Oncological Dispensary. Control cases were 
obtained from previously implemented study of healthy 
Uzbekistan people residing in the same catchment area 
as the majority of our cancer cases.  

Before taking part in a study all study 
participants gave their informed consent. The study was 
conducted according to the standards of the National 
Ethic Committee of Uzbekistan developed in 
accordance with the World Medical Association’s 
Declaration of Helsinki "Ethical Principles For Medical 
Research Involving  Human Subjects" with amendments 
(2013) and approved by NCC MoH UZB. 

According to the previously published data, the 
prevalence of GC in young patients ranged from 4.4% 
to 16.2% of all GC cases when the cut-point was set at 
40 years old.19,20 In light of these studies and also due to 
the fact that intestinal metaplasia, an aging process due 
to acid reflux affecting the gastric mucosa, mostly 

affects patients above the age of 40 years with no 
significant gender difference,21 we also have used this 
cut-point, when dividing the participants into 4 
subgroups. These subgroups were as follows: men older 
than 40 years (n=139), women over 40 years (n=84), 
men up to 40 years (n=29), and women up to 40 years 
of age (n=16).  

Laboratory methods 

Blood samples (2 ml) were drawn from an 
antecubital vein, which were collected using vacutainers 
containing sodium citrate. Samples were stored at 
−20°C until they were ready for analysis. Genomic 
DNA was extracted from peripheral blood leucocytes by 
using DNA extraction kit Diatom™ DNA Prep 200 
(IsoGen Laboratory,22 Moscow, Russia). Rs2294008 
and rs2976392 polymorphisms were genotyped by 
means of polymerase chain reaction-restriction fragment 
length polymorphism (PCR-RFLP). Primer sequences 
for rs2294008 and rs2976392 were as follows:  

Sense5’-GAAACCCGCTGGTGTTGACTGT-
3’ andantisense5’-GGGCAAGCAGCACAGCCTAC-3’ 
forrs2294008; sense 5’-
ATCTTTCTGGCCATCTGTCCGCAGCT-3’ and 
antisense5’-GGCAGATGGACCACCCGCTG-3’ for 
rs2976392. PCR mixture(25 µl) consisted of 13 µl of 
ddH2O, 2.5 µl 10xPCR buffer, 2.5 µl 25 mM MgCl2, 
2.5 µl 2.5 mMdNTP Mix, 1,5 µl (10pkmol/µl) of each 
oligonucleotide primer, 0.3 µl (1.5 units) "hot-start" 
Taq-polymerase, and 3 µl of DNA. PCR amplification 
was carried out in GeneAmp 9700(Applied 
Biosystems). The PCR conditions were as follows for 
rs2294008: 95 °C for 5 minutes, and then 33 cycles of 
94°C for 45 seconds, 62°C for 30 seconds, and 72 °C 
for 30 seconds, and a final extension step of 72°C for 5 
minutes. PCR conditions for rs2976392 were: 95 °C for 
5 minutes, and then 33 cycles of 95°C for 40 seconds, 
60°C for 30 seconds, and 72 °C for 40 seconds, and a 
final extension step of 72°C for 5 minutes. Protocol for 
implementing these studies has been developed at the 
laboratory where this study was conducted. 

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PCR products were digested overnight at 370C 
with HpyCH4IV (New England Biolabs) for rs2294008 
and PvuII (New England BioLabs) for rs2976392 and 
then separated by electrophoresis on 3% agarose with 
ethidium bromide staining and were visualized using 
WiseDoc WGD-30 (DAIHAN, Korea).  

Statistical analysis 

The Hardy-Weinberg equilibrium was tested 
by a goodness-of-fit χ2 test to compare the observed 
genotype frequencies with the expected ones among the 
control subjects. Genotypic associations of SNPs were 
evaluated by Cochran-Armitage trend test, followed by 
risk assessment using odds ratio (OR) and 95% 
confidence of interval (CI) computation. All statistical 
analyses were performed by using STATA software 
version 12.0 for Windows (Stata Corporation, USA). A 
p<0.05 (two-sided) was considered statistically 
significant. 

 

Results 

Genotype frequencies of PSCA rs2294008 and 
rs2976392 polymorphisms in patients with gastric 
cancer and controls are shown in Figures 1 and 2. The 
genotype distributions of these polymorphisms were in 
Hardy–Weinberg equilibrium in control groups 
(p >0.05). 

 

Figure 1: Genotype distribution of prostate stem cell 
antigen rs2294008 polymorphism in control group and 
in subgroup of young women with gastric cancer 

 

Figure 2: Genotype distribution of prostate stem cell 
antigen rs2976392 polymorphism in control group and 
in patients with gastric cancer (both males and females 
included) 

 

Comparative analysis of rs2294008 genotypes 
between patients and controls showed a significant 
association between the CT genotype and gastric cancer 
(p=0.03, additive model of inheritance, Cochran-
Armitage trend test) (see Table 1). The OR of increased 
relative risk of developing gastric cancer for CT 
genotype carriers was 3.11 (95% CI: 2.16 – 4.47). 

 

Table 1: Association between the genotypes of 
rs2294008 and gastric cancer 

 

Comparative analysis of the genotype 
distribution for rs2976392 polymorphism did not show 
a statistically significant difference between the cases 
and controls. For the further analysis of rs2976392 
genotypes, the group of patients with gastric cancer was 
divided into 4 subgroups according to gender and age. 

Comparative analysis of the distribution of 
alleles and genotypes of rs2976392 polymorphism did 
not show a statistically significant difference between 
subgroups of patients and controls for both men and 
women of advanced age (over 40 years) and young men 
(up to 40 years)(see Table 2 and 3). However, analysis 
of the distribution of the rs2976392 genotypes in 
subgroup of young women revealed a statistically 
significant (p=0.04, additive model of inheritance, 
Cochran-Armitage trend test and p=0.03, Fisher’s Exact 
Test) increase in the incidence of AA (38%) and AG 
(56%) genotypes in patients with GC, compared to the 
controls (20% and 41%). The OR of developing gastric 
cancer for carriers of the AA and AG genotype was 2.35 
(95% CI: 0.71-7.76) and 1.88 (95% CI: 0.61-5.72), 
respectively.  

 

Table 2: Comparative analysis of the distribution of 
alleles of rs2976392 and gastric cancer 

 

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Table 3: Association between the genotype frequencies 
of rs2976392 and gastric cancer 

 
Discussion 

Results of our study confirm the association 
between the T allele of rs2294008 (CT genotype) with 
GC risk. Three previous GWAS studies revealed a 
significant association of the T allele of rs2294008 with 
the risk of GC9,23,24 and the C allele for duodenal ulcer.25 
Several case-control studies replicated the association of 
this SNP with GC in Asian and Caucasian 
populations.26,27 

The results of the present study also indicated 
that genetic effect of PSCA rs2976392 polymorphism in 
Uzbek population is only present in the subgroup of 
women under the age of 40. This is consistent with the 
fact that complex genetic diseases, such GC are likely to 
arise due to multiple, potentially interacting, genetic and 
environmental factors, and therefore are challenging to 
study. Presumably, many of these environmental and 
genetic risk factors are interconnected, with other 
factors, such as ethnicity, specific genetic background, 
and endocrine factors, and are likely to be key modifiers 
of these risk factors. This general phenomenon is known 
as effect modification, and represents an interaction 
between two or more variables.   

There is some evidence regarding the potential 
role of estrogen receptors in the regulation of normal 
development and functioning of the gastric mucosa 
cells, as well as in the process of tumorogenesis28, 
which provide an intriguing reason to investigate the 
stomach in relation to estrogen exposure. In this respect, 
some authors have suggested a close link between 
receptor mechanism of estrogen action and the growth 
and proliferation of gastric tumor cells. In one-third of 
patients with gastric cancer, estrogen receptors have 
been identified in gastric tumors, suggesting a possible 
involvement of estrogens in GC development.29 At the 
molecular level, the estrogen receptors function as 

ligand dependent transcriptional factors that activate or 
inhibit the expression of target genes in response to 
hormonal stimulation. It is also interesting to note that 
estrogen receptors regulate PSCA gene expression, 
since there is an "ER-binding site" in the promoter 
region of PSCA gene.30 Perhaps this may explain the 
association of rs2976392 with GC in the subgroup of 
young women, since they have high levels of estrogen 
hormones. 

It should be noted that there are several 
limitations of this study. The data concerning subgroup 
of young women (under the age of 40) with GC may not 
accurately reflect the prevalence of rs2976392 
genotypes in the general population of young women of 
Uzbekistan because of the small sample size of this 
subgroup. A large-scale study of young women with GC 
is needed to evaluate more precisely the contribution of 
these genotypes to the development of GC in this 
cohort. Our future studies will evaluate more closely the 
contribution of Helicobacter Pylori infection to the GC 
in our cohorts. Overall, considering the burden of GC in 
Asia, this study is very important for Uzbekistan and the 
entire Asian continent. In addition, further research on 
deep sequencing of the PSCA gene is needed to 
determine the full allelic spectrum of causal variants 
underlying predisposition to GC and to discover rare 
variants. It is reasonable to hypothesize that not only the 
common GWAS variants are responsible for GC risk in 
Uzbekistan, but also that these loci may contain high 
effect rare risk variants that have gone undetected by 
GWAS. It is plausible that future analyses of low-
frequency (0.5% ≤ MAF < 5%) and rare (MAF < 0.5%) 
variants of the PSCA gene using Next-Generation 
Sequencing (NGS) technologies could explain 
additional GC disease risk in Uzbekistan. 

In summary, the results of our research 
provided preliminary evidence that PSCA rs2294008 
and rs9297976 polymorphism may contribute to gastric 
cancer risk in Uzbekistan. As studies of this nature are 
rare in Uzbekistan, this research has important 

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implications for both Uzbekistan, and Central Asian 
population due to high burden of GC.  Genotyping of 
these polymorphisms can potentially be recommended 
as a criterion for identification of high risk groups for 
the development of gastric cancer in Uzbekistan. 

 

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2010;42(11):978-984. 

24. Wu X, Ye Y, Kiemeney LA, et al. Genetic variation in the 
prostate stem cell antigen gene PSCA confers susceptibility to 
urinary bladder cancer. Nat Genet. 2009;41(9):991-995. 

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http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/stomach-cancer-statistics
http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/stomach-cancer-statistics
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25. Tanikawa C, Urabe Y, Matsuo K, et al. A genome-wide 
association study identifies two susceptibility loci for duodenal 
ulcer in the Japanese population. Nat Genet. 2012;44(4):430-
434, S431-432. 

26. Chandra V, Kim JJ, Gupta U, Mittal B, Rai R. Impact of 
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Polymorphism in Modulating Cancer Risk in Asian Population. 
Genes (Basel). 2016;7(2). 

27. Gu Y, Dai QS, Hua RX, et al. PSCA s2294008 C>T and 
rs2976392 G>A polymorphisms contribute to cancer 
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Langman, MJS. Differential expression of oestrogen receptor 

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CENTRAL ASIAN JOURNAL OF GLOBAL HEALTH 
 

 

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of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 
Central Asian Journal of Global Health 

Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Figure 1: Genotype distribution of prostate stem cell antigen rs2294008 polymorphism in 

control group and in subgroup of young women with gastric cancer 

 

 

 

 

 

 

 
  

0%

10%

20%

30%

40%

50%

60%

CC CT TT

20% 

41% 39% 38% 

56% 

6% 

Control

Cases

Genotype 

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This work is licensed under a Creative Commons Attribution 4.0 United States License. 

 
This journal is published by theUniversity Library System of the University of Pittsburgh as part  

of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 
 

Central Asian Journal of Global Health 
Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Figure 2: Genotype distribution of prostate stem cell antigen rs2976392 polymorphism in 

control group and in patients with gastric cancer (both males and females included) 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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CENTRAL ASIAN JOURNAL OF GLOBAL HEALTH 
 

 

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This journal is published by theUniversity Library System of the University of Pittsburgh as part  
of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 

 
Central Asian Journal of Global Health 

Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Table 1: Association between the genotypes of rs2294008 and gastric cancer 

Genotype 
Controls  Cases  

Additive model* OR (95% CI) 
N (%) N(%) 

CC 119 (48) 78 (29) 
χ2= 4.97 

p=0.03 

0.45 (0.31 – 0.64) 

CT 109 (44) 190 (71) 3.11 (2.16 – 4.47) 

TT 20 (8) 0 (0) 0.02 (0.00 – 0.35) 

*Using Cochran-Armitage trend test 

  

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of its D-Scribe Digital Publishing Program and is cosponsored by the University of Pittsburgh Press. 
 

Central Asian Journal of Global Health 
Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Table 2: Comparative analysis of the distribution of alleles of rs2976392 and gastric cancer 

Subgroup Genotype 
Controls  Cases 

Additive model OR (95% CI) 
N (%) N (%) 

Men (>40 yrs) 

AA 14 (24) 40 (29) 
χ2= 0.12 

p=0.73 

1.70 (0.86 – 3.39) 

AG 38 (52) 51 (36) 0.53(0.30 – 0.95) 

GG 21 (24) 48 (35) 1.31(0.71 – 2.42) 

Women (>40 yrs) 

AA 12 (21) 21 (25) 
χ2=1.16 

p=0.28 

1.28 (0.57 – 2.86) 

AG 21 (36) 35 (42) 1.26 (0.63 – 2.51) 

GG 25 (43) 28 (33) 0.66 (0.33 – 1.32) 

Men (≤40 yrs) 

AA 9 (16) 7 (24) 
χ2=0.11 

p=0.74 

1.73(0.57 – 5.25) 

AG 31 (53) 12 (41) 0.61(0.25 – 1.51) 

GG 18 (31) 10 (35) 1.17(0.45 – 3.01) 

Women (≤40 yrs) 

AA 12 (20) 6 (38) 
χ2= 6.45 

p=0.04 

2.35 (0.71-7.76) 

AG 24 (41) 9 (56) 1.88(0.61-5.72) 

GG 23 (39) 1 (6) 0.10(0.01-0.84) 

*Using Cochran-Armitage trend test 

 
  

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CENTRAL ASIAN JOURNAL OF GLOBAL HEALTH 
 

 

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Central Asian Journal of Global Health 

Volume 5, No. 1 (2016) |  ISSN 2166-7403 (online) | DOI 10.5195/cajgh.2016.227|http://cajgh.pitt.edu 

 
 

Table 3: Association between the genotype frequencies of rs2976392 and gastric cancer   

Subgroup Genotype 
Controls  Cases 

p-value* 
N (%) N (%) 

Men (>40 yrs) 

AA 14 (24) 40 (29) 

p=0.09 AG 38 (52) 51 (36) 

GG 21 (24) 48 (35) 

Women (>40 yrs) 

AA 12 (21) 21 (25) 

p=0.49 AG 21 (36) 35 (42) 

GG 25 (43) 28 (33) 

Men (≤40 yrs) 

AA 9 (16) 7 (24) 
p=0.49 

 
AG 31 (53) 12 (41) 

GG 18 (31) 10 (35) 

Women (≤40 yrs) 

AA 12 (20) 6 (38) 

p=0.03 AG 24 (41) 9 (56) 

GG 23 (39) 1 (6) 

*Using Fisher’s Exact test 

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	Association of rs2294008 and rs9297976 Polymorphisms in PSCA Gene with Gastric Cancer Susceptibility in Uzbekistan
	Abstract
	Keywords: Gastric cancer, rs2294008, rs9297976, genotyping, Uzbekistan
	Association of rs2294008 and rs9297976 Polymorphisms in PSCA Gene with Gastric Cancer Susceptibility in Uzbekistan
	Research

