id	sid	tid	token	lemma	pos
cajgh-231	1	1	cajgh_template	cajgh_template	ADJ
cajgh-231	1	2	new	new	ADJ
cajgh-231	1	3	articles	article	NOUN
cajgh-231	1	4	in	in	ADP
cajgh-231	1	5	this	this	DET
cajgh-231	1	6	journal	journal	NOUN
cajgh-231	1	7	are	be	AUX
cajgh-231	1	8	licensed	license	VERB
cajgh-231	1	9	under	under	ADP
cajgh-231	1	10	a	a	DET
cajgh-231	1	11	creative	creative	ADJ
cajgh-231	1	12	commons	common	NOUN
cajgh-231	1	13	attribution	attribution	NOUN
cajgh-231	1	14	4.0	4.0	NUM
cajgh-231	1	15	united	unite	VERB
cajgh-231	1	16	states	states	PROPN
cajgh-231	1	17	license	license	NOUN
cajgh-231	1	18	.	.	PUNCT
cajgh-231	2	1	this	this	DET
cajgh-231	2	2	journal	journal	NOUN
cajgh-231	2	3	is	be	AUX
cajgh-231	2	4	published	publish	VERB
cajgh-231	2	5	by	by	ADP
cajgh-231	2	6	theuniversity	theuniversity	NOUN
cajgh-231	2	7	library	library	NOUN
cajgh-231	2	8	system	system	NOUN
cajgh-231	2	9	of	of	ADP
cajgh-231	2	10	the	the	DET
cajgh-231	2	11	university	university	PROPN
cajgh-231	2	12	of	of	ADP
cajgh-231	2	13	pittsburgh	pittsburgh	PROPN
cajgh-231	2	14	as	as	ADP
cajgh-231	2	15	part	part	NOUN
cajgh-231	2	16	of	of	ADP
cajgh-231	2	17	its	its	PRON
cajgh-231	2	18	d	d	NOUN
cajgh-231	2	19	-	-	PUNCT
cajgh-231	2	20	scribe	scribe	VERB
cajgh-231	2	21	digital	digital	ADJ
cajgh-231	2	22	publishing	publishing	NOUN
cajgh-231	2	23	program	program	NOUN
cajgh-231	2	24	and	and	CCONJ
cajgh-231	2	25	is	be	AUX
cajgh-231	2	26	cosponsored	cosponsor	VERB
cajgh-231	2	27	by	by	ADP
cajgh-231	2	28	the	the	DET
cajgh-231	2	29	university	university	PROPN
cajgh-231	2	30	of	of	ADP
cajgh-231	2	31	pittsburgh	pittsburgh	PROPN
cajgh-231	2	32	press	press	NOUN
cajgh-231	2	33	.	.	PUNCT
cajgh-231	3	1	the	the	DET
cajgh-231	3	2	universal	universal	ADJ
cajgh-231	3	3	non	non	ADJ
cajgh-231	3	4	-	-	ADJ
cajgh-231	3	5	neuronal	neuronal	ADJ
cajgh-231	3	6	nature	nature	NOUN
cajgh-231	3	7	of	of	ADP
cajgh-231	3	8	parkinson	parkinson	NOUN
cajgh-231	3	9	’s	’s	PART
cajgh-231	3	10	disease	disease	NOUN
cajgh-231	3	11	:	:	PUNCT
cajgh-231	3	12	a	a	DET
cajgh-231	3	13	theory	theory	NOUN
cajgh-231	3	14	andré	andré	VERB
cajgh-231	3	15	x.	x.	PROPN
cajgh-231	3	16	c.	c.	PROPN
cajgh-231	3	17	n.	n.	PROPN
cajgh-231	3	18	valente1,2,3	valente1,2,3	PROPN
cajgh-231	3	19	,	,	PUNCT
cajgh-231	3	20	altynai	altynai	VERB
cajgh-231	3	21	adilbayeva4,tursonjan	adilbayeva4,tursonjan	PUNCT
cajgh-231	4	1	tokay4	tokay4	PROPN
cajgh-231	4	2	,	,	PUNCT
cajgh-231	4	3	albert	albert	PROPN
cajgh-231	4	4	a.	a.	PROPN
cajgh-231	4	5	rizvanov3	rizvanov3	PROPN
cajgh-231	5	1	1center	1center	NUM
cajgh-231	5	2	for	for	ADP
cajgh-231	5	3	neuroscience	neuroscience	NOUN
cajgh-231	5	4	and	and	CCONJ
cajgh-231	5	5	cell	cell	NOUN
cajgh-231	5	6	biology	biology	NOUN
cajgh-231	5	7	,	,	PUNCT
cajgh-231	5	8	university	university	NOUN
cajgh-231	5	9	of	of	ADP
cajgh-231	5	10	coimbra	coimbra	PROPN
cajgh-231	5	11	,	,	PUNCT
cajgh-231	5	12	cantanhede	cantanhede	NOUN
cajgh-231	5	13	,	,	PUNCT
cajgh-231	5	14	portugal	portugal	PROPN
cajgh-231	5	15	;	;	PUNCT
cajgh-231	5	16	2biocant	2biocant	NUM
cajgh-231	5	17	biotechnology	biotechnology	NOUN
cajgh-231	5	18	innovation	innovation	NOUN
cajgh-231	5	19	center	center	NOUN
cajgh-231	5	20	,	,	PUNCT
cajgh-231	5	21	cantanhede	cantanhede	NOUN
cajgh-231	5	22	,	,	PUNCT
cajgh-231	5	23	portugal	portugal	PROPN
cajgh-231	5	24	;	;	PUNCT
cajgh-231	5	25	3institute	3institute	NUM
cajgh-231	5	26	of	of	ADP
cajgh-231	5	27	fundamental	fundamental	ADJ
cajgh-231	5	28	medicine	medicine	NOUN
cajgh-231	5	29	and	and	CCONJ
cajgh-231	5	30	biology	biology	NOUN
cajgh-231	5	31	,	,	PUNCT
cajgh-231	5	32	kazan	kazan	PROPN
cajgh-231	5	33	federal	federal	PROPN
cajgh-231	5	34	university	university	PROPN
cajgh-231	5	35	,	,	PUNCT
cajgh-231	5	36	kazan	kazan	PROPN
cajgh-231	5	37	,	,	PUNCT
cajgh-231	5	38	russia	russia	PROPN
cajgh-231	5	39	;	;	PUNCT
cajgh-231	5	40	4national	4national	NUM
cajgh-231	5	41	laboratory	laboratory	NOUN
cajgh-231	5	42	astana	astana	PROPN
cajgh-231	5	43	,	,	PUNCT
cajgh-231	5	44	nazarbayev	nazarbayev	ADJ
cajgh-231	5	45	university	university	PROPN
cajgh-231	5	46	,	,	PUNCT
cajgh-231	5	47	astana	astana	PROPN
cajgh-231	5	48	,	,	PUNCT
cajgh-231	5	49	kazakhstan	kazakhstan	PROPN
cajgh-231	5	50	vol	vol	NOUN
cajgh-231	5	51	.	.	PROPN
cajgh-231	6	1	4	4	NUM
cajgh-231	6	2	,	,	PUNCT
cajgh-231	6	3	no	no	INTJ
cajgh-231	6	4	.	.	NOUN
cajgh-231	6	5	1	1	NUM
cajgh-231	6	6	(	(	PUNCT
cajgh-231	6	7	2015	2015	NUM
cajgh-231	6	8	)	)	PUNCT
cajgh-231	6	9	|	|	ADV
cajgh-231	6	10	issn	issn	VERB
cajgh-231	6	11	2166	2166	NUM
cajgh-231	6	12	-	-	SYM
cajgh-231	6	13	7403	7403	NUM
cajgh-231	6	14	(	(	PUNCT
cajgh-231	6	15	online	online	ADJ
cajgh-231	6	16	)	)	PUNCT
cajgh-231	6	17	doi	doi	NOUN
cajgh-231	6	18	10.5195	10.5195	NUM
cajgh-231	6	19	/	/	SYM
cajgh-231	6	20	cajgh.2016.231	cajgh.2016.231	VERB
cajgh-231	6	21	|	|	NOUN
cajgh-231	6	22	http://cajgh.pitt.edu	http://cajgh.pitt.edu	NOUN
cajgh-231	6	23	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	6	24	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	6	25	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	7	1	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	7	2	http://creativecommons.org/licenses/by/3.0/us/	http://creativecommons.org/licenses/by/3.0/us/	PROPN
cajgh-231	7	3	valente	valente	NOUN
cajgh-231	7	4	this	this	DET
cajgh-231	7	5	work	work	NOUN
cajgh-231	7	6	is	be	AUX
cajgh-231	7	7	licensed	license	VERB
cajgh-231	7	8	under	under	ADP
cajgh-231	7	9	a	a	DET
cajgh-231	7	10	creative	creative	ADJ
cajgh-231	7	11	commons	common	NOUN
cajgh-231	7	12	attribution	attribution	NOUN
cajgh-231	7	13	4.0	4.0	NUM
cajgh-231	7	14	united	unite	VERB
cajgh-231	7	15	states	states	PROPN
cajgh-231	7	16	license	license	NOUN
cajgh-231	7	17	.	.	PUNCT
cajgh-231	8	1	this	this	DET
cajgh-231	8	2	journal	journal	NOUN
cajgh-231	8	3	is	be	AUX
cajgh-231	8	4	published	publish	VERB
cajgh-231	8	5	by	by	ADP
cajgh-231	8	6	theuniversity	theuniversity	NOUN
cajgh-231	8	7	library	library	NOUN
cajgh-231	8	8	system	system	NOUN
cajgh-231	8	9	of	of	ADP
cajgh-231	8	10	the	the	DET
cajgh-231	8	11	university	university	PROPN
cajgh-231	8	12	of	of	ADP
cajgh-231	8	13	pittsburgh	pittsburgh	PROPN
cajgh-231	8	14	as	as	ADP
cajgh-231	8	15	part	part	NOUN
cajgh-231	8	16	of	of	ADP
cajgh-231	8	17	its	its	PRON
cajgh-231	8	18	d	d	NOUN
cajgh-231	8	19	-	-	PUNCT
cajgh-231	8	20	scribe	scribe	VERB
cajgh-231	8	21	digital	digital	ADJ
cajgh-231	8	22	publishing	publishing	NOUN
cajgh-231	8	23	program	program	NOUN
cajgh-231	8	24	and	and	CCONJ
cajgh-231	8	25	is	be	AUX
cajgh-231	8	26	cosponsored	cosponsor	VERB
cajgh-231	8	27	by	by	ADP
cajgh-231	8	28	the	the	DET
cajgh-231	8	29	university	university	PROPN
cajgh-231	8	30	of	of	ADP
cajgh-231	8	31	pittsburgh	pittsburgh	PROPN
cajgh-231	8	32	press	press	NOUN
cajgh-231	8	33	.	.	PUNCT
cajgh-231	9	1	central	central	ADJ
cajgh-231	9	2	asian	asian	ADJ
cajgh-231	9	3	journal	journal	NOUN
cajgh-231	9	4	of	of	ADP
cajgh-231	9	5	global	global	ADJ
cajgh-231	9	6	health	health	NOUN
cajgh-231	9	7	volume	volume	NOUN
cajgh-231	9	8	4	4	NUM
cajgh-231	9	9	,	,	PUNCT
cajgh-231	9	10	no	no	INTJ
cajgh-231	9	11	.	.	NOUN
cajgh-231	9	12	1	1	NUM
cajgh-231	9	13	(	(	PUNCT
cajgh-231	9	14	2015	2015	NUM
cajgh-231	9	15	)	)	PUNCT
cajgh-231	9	16	|	|	ADV
cajgh-231	9	17	issn	issn	VERB
cajgh-231	9	18	2166	2166	NUM
cajgh-231	9	19	-	-	SYM
cajgh-231	9	20	7403	7403	NUM
cajgh-231	9	21	(	(	PUNCT
cajgh-231	9	22	online	online	ADJ
cajgh-231	9	23	)	)	PUNCT
cajgh-231	9	24	|	|	ADV
cajgh-231	9	25	doi	doi	X
cajgh-231	9	26	10.5195	10.5195	NUM
cajgh-231	9	27	/	/	SYM
cajgh-231	9	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	9	29	abstract	abstract	ADJ
cajgh-231	9	30	parkinson	parkinson	NOUN
cajgh-231	9	31	's	's	PART
cajgh-231	9	32	disease	disease	NOUN
cajgh-231	9	33	(	(	PUNCT
cajgh-231	9	34	pd	pd	NOUN
cajgh-231	9	35	)	)	PUNCT
cajgh-231	9	36	is	be	AUX
cajgh-231	9	37	one	one	NUM
cajgh-231	9	38	of	of	ADP
cajgh-231	9	39	the	the	DET
cajgh-231	9	40	most	most	ADV
cajgh-231	9	41	common	common	ADJ
cajgh-231	9	42	neurodegenerative	neurodegenerative	ADJ
cajgh-231	9	43	disorders	disorder	NOUN
cajgh-231	9	44	,	,	PUNCT
cajgh-231	9	45	yet	yet	CCONJ
cajgh-231	9	46	the	the	DET
cajgh-231	9	47	etiology	etiology	NOUN
cajgh-231	9	48	of	of	ADP
cajgh-231	9	49	the	the	DET
cajgh-231	9	50	majority	majority	NOUN
cajgh-231	9	51	of	of	ADP
cajgh-231	9	52	its	its	PRON
cajgh-231	9	53	cases	case	NOUN
cajgh-231	9	54	remains	remain	VERB
cajgh-231	9	55	unknown	unknown	ADJ
cajgh-231	9	56	.	.	PUNCT
cajgh-231	10	1	in	in	ADP
cajgh-231	10	2	this	this	DET
cajgh-231	10	3	manuscript	manuscript	NOUN
cajgh-231	10	4	,	,	PUNCT
cajgh-231	10	5	relevant	relevant	ADJ
cajgh-231	10	6	published	publish	VERB
cajgh-231	10	7	evidence	evidence	NOUN
cajgh-231	10	8	is	be	AUX
cajgh-231	10	9	interpreted	interpret	VERB
cajgh-231	10	10	and	and	CCONJ
cajgh-231	10	11	integrated	integrate	VERB
cajgh-231	10	12	into	into	ADP
cajgh-231	10	13	a	a	DET
cajgh-231	10	14	comprehensive	comprehensive	ADJ
cajgh-231	10	15	hypothesis	hypothesis	NOUN
cajgh-231	10	16	on	on	ADP
cajgh-231	10	17	the	the	DET
cajgh-231	10	18	nature	nature	NOUN
cajgh-231	10	19	,	,	PUNCT
cajgh-231	10	20	origin	origin	NOUN
cajgh-231	10	21	,	,	PUNCT
cajgh-231	10	22	and	and	CCONJ
cajgh-231	10	23	inter	inter	ADJ
cajgh-231	10	24	-	-	ADJ
cajgh-231	10	25	cellular	cellular	ADJ
cajgh-231	10	26	mode	mode	NOUN
cajgh-231	10	27	of	of	ADP
cajgh-231	10	28	propagation	propagation	NOUN
cajgh-231	10	29	of	of	ADP
cajgh-231	10	30	sporadic	sporadic	ADJ
cajgh-231	10	31	pd	pd	PROPN
cajgh-231	10	32	.	.	PUNCT
cajgh-231	11	1	we	we	PRON
cajgh-231	11	2	propose	propose	VERB
cajgh-231	11	3	to	to	PART
cajgh-231	11	4	characterize	characterize	VERB
cajgh-231	11	5	sporadic	sporadic	ADJ
cajgh-231	11	6	pd	pd	PROPN
cajgh-231	11	7	as	as	ADP
cajgh-231	11	8	a	a	DET
cajgh-231	11	9	pathological	pathological	ADJ
cajgh-231	11	10	deviation	deviation	NOUN
cajgh-231	11	11	in	in	ADP
cajgh-231	11	12	the	the	DET
cajgh-231	11	13	global	global	ADJ
cajgh-231	11	14	gene	gene	NOUN
cajgh-231	11	15	expression	expression	NOUN
cajgh-231	11	16	program	program	NOUN
cajgh-231	11	17	of	of	ADP
cajgh-231	11	18	a	a	DET
cajgh-231	11	19	cell	cell	NOUN
cajgh-231	11	20	:	:	PUNCT
cajgh-231	11	21	the	the	DET
cajgh-231	11	22	pd	pd	PROPN
cajgh-231	11	23	expression	expression	NOUN
cajgh-231	11	24	-	-	PUNCT
cajgh-231	11	25	state	state	NOUN
cajgh-231	11	26	,	,	PUNCT
cajgh-231	11	27	or	or	CCONJ
cajgh-231	11	28	pd	pd	NOUN
cajgh-231	11	29	-	-	NOUN
cajgh-231	11	30	state	state	NOUN
cajgh-231	11	31	for	for	ADP
cajgh-231	11	32	short	short	ADJ
cajgh-231	11	33	.	.	PUNCT
cajgh-231	12	1	a	a	DET
cajgh-231	12	2	universal	universal	ADJ
cajgh-231	12	3	cell	cell	NOUN
cajgh-231	12	4	-	-	PUNCT
cajgh-231	12	5	generic	generic	ADJ
cajgh-231	12	6	state	state	NOUN
cajgh-231	12	7	,	,	PUNCT
cajgh-231	12	8	the	the	DET
cajgh-231	12	9	pd	pd	ADJ
cajgh-231	12	10	-	-	PUNCT
cajgh-231	12	11	state	state	NOUN
cajgh-231	12	12	deviation	deviation	NOUN
cajgh-231	12	13	would	would	AUX
cajgh-231	12	14	be	be	AUX
cajgh-231	12	15	particularly	particularly	ADV
cajgh-231	12	16	damaging	damaging	ADJ
cajgh-231	12	17	in	in	ADP
cajgh-231	12	18	a	a	DET
cajgh-231	12	19	neuronal	neuronal	ADJ
cajgh-231	12	20	context	context	NOUN
cajgh-231	12	21	,	,	PUNCT
cajgh-231	12	22	ultimately	ultimately	ADV
cajgh-231	12	23	leading	lead	VERB
cajgh-231	12	24	to	to	ADP
cajgh-231	12	25	neuron	neuron	VERB
cajgh-231	12	26	death	death	NOUN
cajgh-231	12	27	and	and	CCONJ
cajgh-231	12	28	the	the	DET
cajgh-231	12	29	ensuing	ensue	VERB
cajgh-231	12	30	observed	observe	VERB
cajgh-231	12	31	clinical	clinical	ADJ
cajgh-231	12	32	signs	sign	NOUN
cajgh-231	12	33	.	.	PUNCT
cajgh-231	13	1	we	we	PRON
cajgh-231	13	2	review	review	VERB
cajgh-231	13	3	why	why	SCONJ
cajgh-231	13	4	ageing	age	VERB
cajgh-231	13	5	associated	associated	ADJ
cajgh-231	13	6	accumulated	accumulate	VERB
cajgh-231	13	7	damage	damage	NOUN
cajgh-231	13	8	caused	cause	VERB
cajgh-231	13	9	by	by	ADP
cajgh-231	13	10	oxidative	oxidative	ADJ
cajgh-231	13	11	stress	stress	NOUN
cajgh-231	13	12	in	in	ADP
cajgh-231	13	13	mitochondria	mitochondria	NOUN
cajgh-231	13	14	could	could	AUX
cajgh-231	13	15	be	be	AUX
cajgh-231	13	16	the	the	DET
cajgh-231	13	17	trigger	trigger	NOUN
cajgh-231	13	18	for	for	SCONJ
cajgh-231	13	19	a	a	DET
cajgh-231	13	20	primordial	primordial	ADJ
cajgh-231	13	21	cell	cell	NOUN
cajgh-231	13	22	to	to	PART
cajgh-231	13	23	shift	shift	VERB
cajgh-231	13	24	to	to	ADP
cajgh-231	13	25	the	the	DET
cajgh-231	13	26	pd	pd	NOUN
cajgh-231	13	27	-	-	NOUN
cajgh-231	13	28	state	state	NOUN
cajgh-231	13	29	.	.	PUNCT
cajgh-231	14	1	we	we	PRON
cajgh-231	14	2	propose	propose	VERB
cajgh-231	14	3	that	that	SCONJ
cajgh-231	14	4	hematopoietic	hematopoietic	ADJ
cajgh-231	14	5	cells	cell	NOUN
cajgh-231	14	6	could	could	AUX
cajgh-231	14	7	be	be	AUX
cajgh-231	14	8	the	the	DET
cajgh-231	14	9	first	first	ADJ
cajgh-231	14	10	to	to	PART
cajgh-231	14	11	acquire	acquire	VERB
cajgh-231	14	12	the	the	DET
cajgh-231	14	13	pd	pd	NOUN
cajgh-231	14	14	-	-	NOUN
cajgh-231	14	15	state	state	NOUN
cajgh-231	14	16	,	,	PUNCT
cajgh-231	14	17	at	at	ADP
cajgh-231	14	18	hematopoiesis	hematopoiesis	NOUN
cajgh-231	14	19	,	,	PUNCT
cajgh-231	14	20	from	from	ADP
cajgh-231	14	21	the	the	DET
cajgh-231	14	22	disruption	disruption	NOUN
cajgh-231	14	23	in	in	ADP
cajgh-231	14	24	reactive	reactive	ADJ
cajgh-231	14	25	oxygen	oxygen	NOUN
cajgh-231	14	26	species	specie	NOUN
cajgh-231	14	27	homeostasis	homeostasis	NOUN
cajgh-231	14	28	that	that	PRON
cajgh-231	14	29	arises	arise	VERB
cajgh-231	14	30	with	with	ADP
cajgh-231	14	31	age	age	NOUN
cajgh-231	14	32	in	in	ADP
cajgh-231	14	33	the	the	DET
cajgh-231	14	34	hematopoietic	hematopoietic	ADJ
cajgh-231	14	35	stem	stem	NOUN
cajgh-231	14	36	-	-	PUNCT
cajgh-231	14	37	cell	cell	NOUN
cajgh-231	14	38	niche	niche	NOUN
cajgh-231	14	39	.	.	PUNCT
cajgh-231	15	1	we	we	PRON
cajgh-231	15	2	argue	argue	VERB
cajgh-231	15	3	that	that	SCONJ
cajgh-231	15	4	cellular	cellular	ADJ
cajgh-231	15	5	ageing	ageing	NOUN
cajgh-231	15	6	is	be	AUX
cajgh-231	15	7	nevertheless	nevertheless	ADV
cajgh-231	15	8	unlikely	unlikely	ADJ
cajgh-231	15	9	to	to	PART
cajgh-231	15	10	explain	explain	VERB
cajgh-231	15	11	the	the	DET
cajgh-231	15	12	shift	shift	NOUN
cajgh-231	15	13	to	to	ADP
cajgh-231	15	14	the	the	DET
cajgh-231	15	15	pd	pd	NOUN
cajgh-231	15	16	-	-	NOUN
cajgh-231	15	17	state	state	NOUN
cajgh-231	15	18	of	of	ADP
cajgh-231	15	19	all	all	DET
cajgh-231	15	20	the	the	DET
cajgh-231	15	21	subsequently	subsequently	ADV
cajgh-231	15	22	affected	affect	VERB
cajgh-231	15	23	cells	cell	NOUN
cajgh-231	15	24	in	in	ADP
cajgh-231	15	25	a	a	DET
cajgh-231	15	26	patient	patient	NOUN
cajgh-231	15	27	,	,	PUNCT
cajgh-231	15	28	thus	thus	ADV
cajgh-231	15	29	indicating	indicate	VERB
cajgh-231	15	30	the	the	DET
cajgh-231	15	31	existence	existence	NOUN
cajgh-231	15	32	of	of	ADP
cajgh-231	15	33	a	a	DET
cajgh-231	15	34	distinct	distinct	ADJ
cajgh-231	15	35	mechanism	mechanism	NOUN
cajgh-231	15	36	of	of	ADP
cajgh-231	15	37	cellular	cellular	ADJ
cajgh-231	15	38	propagation	propagation	NOUN
cajgh-231	15	39	of	of	ADP
cajgh-231	15	40	the	the	DET
cajgh-231	15	41	pd	pd	NOUN
cajgh-231	15	42	-	-	NOUN
cajgh-231	15	43	state	state	NOUN
cajgh-231	15	44	.	.	PUNCT
cajgh-231	16	1	we	we	PRON
cajgh-231	16	2	highlight	highlight	AUX
cajgh-231	16	3	recently	recently	ADV
cajgh-231	16	4	published	publish	VERB
cajgh-231	16	5	findings	finding	NOUN
cajgh-231	16	6	on	on	ADP
cajgh-231	16	7	the	the	DET
cajgh-231	16	8	inter	inter	ADJ
cajgh-231	16	9	-	-	ADJ
cajgh-231	16	10	cellular	cellular	ADJ
cajgh-231	16	11	exchange	exchange	NOUN
cajgh-231	16	12	of	of	ADP
cajgh-231	16	13	mitochondrial	mitochondrial	ADJ
cajgh-231	16	14	dna	dna	NOUN
cajgh-231	16	15	and	and	CCONJ
cajgh-231	16	16	the	the	DET
cajgh-231	16	17	ability	ability	NOUN
cajgh-231	16	18	of	of	ADP
cajgh-231	16	19	mitochondrial	mitochondrial	ADJ
cajgh-231	16	20	dna	dna	NOUN
cajgh-231	16	21	to	to	PART
cajgh-231	16	22	modulate	modulate	VERB
cajgh-231	16	23	the	the	DET
cajgh-231	16	24	cellular	cellular	ADJ
cajgh-231	16	25	global	global	ADJ
cajgh-231	16	26	gene	gene	NOUN
cajgh-231	16	27	expression	expression	NOUN
cajgh-231	16	28	state	state	NOUN
cajgh-231	16	29	and	and	CCONJ
cajgh-231	16	30	propose	propose	VERB
cajgh-231	16	31	this	this	PRON
cajgh-231	16	32	could	could	AUX
cajgh-231	16	33	form	form	VERB
cajgh-231	16	34	the	the	DET
cajgh-231	16	35	basis	basis	NOUN
cajgh-231	16	36	for	for	ADP
cajgh-231	16	37	the	the	DET
cajgh-231	16	38	intercellular	intercellular	ADJ
cajgh-231	16	39	transmission	transmission	NOUN
cajgh-231	16	40	of	of	ADP
cajgh-231	16	41	the	the	DET
cajgh-231	16	42	pd	pd	NOUN
cajgh-231	16	43	-	-	NOUN
cajgh-231	16	44	state	state	NOUN
cajgh-231	16	45	.	.	PUNCT
cajgh-231	17	1	keywords	keyword	NOUN
cajgh-231	17	2	:	:	PUNCT
cajgh-231	17	3	parkinson	parkinson	NOUN
cajgh-231	17	4	’s	’s	PART
cajgh-231	17	5	disease	disease	NOUN
cajgh-231	17	6	,	,	PUNCT
cajgh-231	17	7	the	the	DET
cajgh-231	17	8	universal	universal	ADJ
cajgh-231	17	9	non	non	ADJ
cajgh-231	17	10	-	-	ADJ
cajgh-231	17	11	neuronal	neuronal	ADJ
cajgh-231	17	12	nature	nature	NOUN
cajgh-231	17	13	of	of	ADP
cajgh-231	17	14	parkinson	parkinson	NOUN
cajgh-231	17	15	’s	’s	PART
cajgh-231	17	16	disease	disease	NOUN
cajgh-231	17	17	:	:	PUNCT
cajgh-231	17	18	a	a	DET
cajgh-231	17	19	theory	theory	NOUN
cajgh-231	17	20	andré	andré	VERB
cajgh-231	17	21	x.	x.	PROPN
cajgh-231	17	22	c.	c.	PROPN
cajgh-231	17	23	n.	n.	PROPN
cajgh-231	17	24	valente1,2,3	valente1,2,3	PROPN
cajgh-231	17	25	,	,	PUNCT
cajgh-231	17	26	altynai	altynai	ADP
cajgh-231	17	27	adilbayeva4	adilbayeva4	PROPN
cajgh-231	17	28	,	,	PUNCT
cajgh-231	17	29	tursonjan	tursonjan	VERB
cajgh-231	17	30	tokay4	tokay4	PROPN
cajgh-231	17	31	,	,	PUNCT
cajgh-231	17	32	albert	albert	PROPN
cajgh-231	17	33	a.	a.	PROPN
cajgh-231	17	34	rizvanov3	rizvanov3	PROPN
cajgh-231	18	1	1center	1center	NUM
cajgh-231	18	2	for	for	ADP
cajgh-231	18	3	neuroscience	neuroscience	NOUN
cajgh-231	18	4	and	and	CCONJ
cajgh-231	18	5	cell	cell	NOUN
cajgh-231	18	6	biology	biology	NOUN
cajgh-231	18	7	,	,	PUNCT
cajgh-231	18	8	university	university	NOUN
cajgh-231	18	9	of	of	ADP
cajgh-231	18	10	coimbra	coimbra	PROPN
cajgh-231	18	11	,	,	PUNCT
cajgh-231	18	12	cantanhede	cantanhede	NOUN
cajgh-231	18	13	,	,	PUNCT
cajgh-231	18	14	portugal	portugal	PROPN
cajgh-231	18	15	;	;	PUNCT
cajgh-231	18	16	2biocant	2biocant	NUM
cajgh-231	18	17	biotechnology	biotechnology	NOUN
cajgh-231	18	18	innovation	innovation	NOUN
cajgh-231	18	19	center	center	NOUN
cajgh-231	18	20	,	,	PUNCT
cajgh-231	18	21	cantanhede	cantanhede	NOUN
cajgh-231	18	22	,	,	PUNCT
cajgh-231	18	23	portugal	portugal	PROPN
cajgh-231	18	24	;	;	PUNCT
cajgh-231	18	25	3institute	3institute	NUM
cajgh-231	18	26	of	of	ADP
cajgh-231	18	27	fundamental	fundamental	ADJ
cajgh-231	18	28	medicine	medicine	NOUN
cajgh-231	18	29	and	and	CCONJ
cajgh-231	18	30	biology	biology	NOUN
cajgh-231	18	31	,	,	PUNCT
cajgh-231	18	32	kazan	kazan	PROPN
cajgh-231	18	33	federal	federal	PROPN
cajgh-231	18	34	university	university	PROPN
cajgh-231	18	35	,	,	PUNCT
cajgh-231	18	36	kazan	kazan	PROPN
cajgh-231	18	37	,	,	PUNCT
cajgh-231	18	38	russia	russia	PROPN
cajgh-231	18	39	;	;	PUNCT
cajgh-231	18	40	4national	4national	NUM
cajgh-231	18	41	laboratory	laboratory	NOUN
cajgh-231	18	42	astana	astana	PROPN
cajgh-231	18	43	,	,	PUNCT
cajgh-231	18	44	nazarbayev	nazarbayev	ADJ
cajgh-231	18	45	university	university	PROPN
cajgh-231	18	46	,	,	PUNCT
cajgh-231	18	47	astana	astana	PROPN
cajgh-231	18	48	,	,	PUNCT
cajgh-231	18	49	kazakhstan	kazakhstan	PROPN
cajgh-231	18	50	research	research	PROPN
cajgh-231	18	51	parkinson	parkinson	NOUN
cajgh-231	18	52	’s	’s	PART
cajgh-231	18	53	disease	disease	NOUN
cajgh-231	18	54	(	(	PUNCT
cajgh-231	18	55	pd	pd	NOUN
cajgh-231	18	56	)	)	PUNCT
cajgh-231	18	57	is	be	AUX
cajgh-231	18	58	a	a	DET
cajgh-231	18	59	common	common	ADJ
cajgh-231	18	60	neurodegenerative	neurodegenerative	ADJ
cajgh-231	18	61	disorder	disorder	NOUN
cajgh-231	18	62	associated	associate	VERB
cajgh-231	18	63	with	with	ADP
cajgh-231	18	64	old	old	ADJ
cajgh-231	18	65	age	age	NOUN
cajgh-231	18	66	.	.	PUNCT
cajgh-231	19	1	the	the	DET
cajgh-231	19	2	number	number	NOUN
cajgh-231	19	3	of	of	ADP
cajgh-231	19	4	worldwide	worldwide	ADJ
cajgh-231	19	5	affected	affected	ADJ
cajgh-231	19	6	individuals	individual	NOUN
cajgh-231	19	7	is	be	AUX
cajgh-231	19	8	estimated	estimate	VERB
cajgh-231	19	9	at	at	ADP
cajgh-231	19	10	7	7	NUM
cajgh-231	19	11	to	to	PART
cajgh-231	19	12	10	10	NUM
cajgh-231	19	13	million.1	million.1	PROPN
cajgh-231	19	14	with	with	ADP
cajgh-231	19	15	population	population	NOUN
cajgh-231	19	16	ageing	ageing	NOUN
cajgh-231	19	17	,	,	PUNCT
cajgh-231	19	18	particularly	particularly	ADV
cajgh-231	19	19	in	in	ADP
cajgh-231	19	20	developing	develop	VERB
cajgh-231	19	21	countries2	countries2	NOUN
cajgh-231	19	22	,	,	PUNCT
cajgh-231	19	23	this	this	DET
cajgh-231	19	24	number	number	NOUN
cajgh-231	19	25	is	be	AUX
cajgh-231	19	26	expected	expect	VERB
cajgh-231	19	27	to	to	PART
cajgh-231	19	28	increase	increase	VERB
cajgh-231	19	29	steeply	steeply	ADV
cajgh-231	19	30	in	in	ADP
cajgh-231	19	31	the	the	DET
cajgh-231	19	32	upcoming	upcoming	ADJ
cajgh-231	19	33	decades	decade	NOUN
cajgh-231	19	34	.	.	PUNCT
cajgh-231	20	1	unfortunately	unfortunately	ADV
cajgh-231	20	2	,	,	PUNCT
cajgh-231	20	3	there	there	PRON
cajgh-231	20	4	is	be	VERB
cajgh-231	20	5	currently	currently	ADV
cajgh-231	20	6	no	no	DET
cajgh-231	20	7	cure	cure	NOUN
cajgh-231	20	8	for	for	ADP
cajgh-231	20	9	pd	pd	PROPN
cajgh-231	20	10	,	,	PUNCT
cajgh-231	20	11	with	with	ADP
cajgh-231	20	12	available	available	ADJ
cajgh-231	20	13	medications	medication	NOUN
cajgh-231	20	14	only	only	ADV
cajgh-231	20	15	providing	provide	VERB
cajgh-231	20	16	symptomatic	symptomatic	ADJ
cajgh-231	20	17	relief.3	relief.3	PROPN
cajgh-231	20	18	pd	pd	PROPN
cajgh-231	20	19	is	be	AUX
cajgh-231	20	20	a	a	DET
cajgh-231	20	21	movement	movement	NOUN
cajgh-231	20	22	disorder	disorder	NOUN
cajgh-231	20	23	clinically	clinically	ADV
cajgh-231	20	24	characterized	characterize	VERB
cajgh-231	20	25	by	by	ADP
cajgh-231	20	26	tremor	tremor	NOUN
cajgh-231	20	27	,	,	PUNCT
cajgh-231	20	28	bradykinesia	bradykinesia	NOUN
cajgh-231	20	29	,	,	PUNCT
cajgh-231	20	30	rigidity	rigidity	NOUN
cajgh-231	20	31	,	,	PUNCT
cajgh-231	20	32	and	and	CCONJ
cajgh-231	20	33	postural	postural	ADJ
cajgh-231	20	34	instability.4	instability.4	ADP
cajgh-231	20	35	the	the	DET
cajgh-231	20	36	motor	motor	NOUN
cajgh-231	20	37	dysfunctions	dysfunction	NOUN
cajgh-231	20	38	are	be	AUX
cajgh-231	20	39	a	a	DET
cajgh-231	20	40	direct	direct	ADJ
cajgh-231	20	41	consequence	consequence	NOUN
cajgh-231	20	42	of	of	ADP
cajgh-231	20	43	the	the	DET
cajgh-231	20	44	death	death	NOUN
cajgh-231	20	45	of	of	ADP
cajgh-231	20	46	dopamine	dopamine	NOUN
cajgh-231	20	47	-	-	PUNCT
cajgh-231	20	48	producing	produce	VERB
cajgh-231	20	49	neurons	neuron	NOUN
cajgh-231	20	50	in	in	ADP
cajgh-231	20	51	the	the	DET
cajgh-231	20	52	substantia	substantia	NOUN
cajgh-231	20	53	nigra	nigra	PROPN
cajgh-231	20	54	pars	par	NOUN
cajgh-231	20	55	compacta	compacta	PROPN
cajgh-231	20	56	region	region	NOUN
cajgh-231	20	57	of	of	ADP
cajgh-231	20	58	the	the	DET
cajgh-231	20	59	midbrain	midbrain	NOUN
cajgh-231	20	60	.	.	PUNCT
cajgh-231	21	1	histologically	histologically	PROPN
cajgh-231	21	2	,	,	PUNCT
cajgh-231	21	3	the	the	DET
cajgh-231	21	4	most	most	ADV
cajgh-231	21	5	noticeable	noticeable	ADJ
cajgh-231	21	6	feature	feature	NOUN
cajgh-231	21	7	of	of	ADP
cajgh-231	21	8	pd	pd	PROPN
cajgh-231	21	9	are	be	AUX
cajgh-231	21	10	abnormal	abnormal	ADJ
cajgh-231	21	11	aggregates	aggregate	NOUN
cajgh-231	21	12	of	of	ADP
cajgh-231	21	13	proteins	protein	NOUN
cajgh-231	21	14	,	,	PUNCT
cajgh-231	21	15	called	call	VERB
cajgh-231	21	16	lewy	lewy	PROPN
cajgh-231	21	17	bodies	body	NOUN
cajgh-231	21	18	and	and	CCONJ
cajgh-231	21	19	lewy	lewy	PROPN
cajgh-231	21	20	neurites	neurites	PROPN
cajgh-231	21	21	,	,	PUNCT
cajgh-231	21	22	that	that	PRON
cajgh-231	21	23	appear	appear	VERB
cajgh-231	21	24	in	in	ADP
cajgh-231	21	25	the	the	DET
cajgh-231	21	26	cell	cell	NOUN
cajgh-231	21	27	body	body	NOUN
cajgh-231	21	28	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	21	29	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	21	30	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	21	31	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	21	32	central	central	ADJ
cajgh-231	21	33	asian	asian	ADJ
cajgh-231	21	34	journal	journal	NOUN
cajgh-231	21	35	of	of	ADP
cajgh-231	21	36	global	global	ADJ
cajgh-231	21	37	health	health	NOUN
cajgh-231	21	38	this	this	DET
cajgh-231	21	39	work	work	NOUN
cajgh-231	21	40	is	be	AUX
cajgh-231	21	41	licensed	license	VERB
cajgh-231	21	42	under	under	ADP
cajgh-231	21	43	a	a	DET
cajgh-231	21	44	creative	creative	ADJ
cajgh-231	21	45	commons	common	NOUN
cajgh-231	21	46	attribution	attribution	NOUN
cajgh-231	21	47	4.0	4.0	NUM
cajgh-231	21	48	united	unite	VERB
cajgh-231	21	49	states	states	PROPN
cajgh-231	21	50	license	license	NOUN
cajgh-231	21	51	.	.	PUNCT
cajgh-231	22	1	this	this	DET
cajgh-231	22	2	journal	journal	NOUN
cajgh-231	22	3	is	be	AUX
cajgh-231	22	4	published	publish	VERB
cajgh-231	22	5	by	by	ADP
cajgh-231	22	6	theuniversity	theuniversity	NOUN
cajgh-231	22	7	library	library	NOUN
cajgh-231	22	8	system	system	NOUN
cajgh-231	22	9	of	of	ADP
cajgh-231	22	10	the	the	DET
cajgh-231	22	11	university	university	PROPN
cajgh-231	22	12	of	of	ADP
cajgh-231	22	13	pittsburgh	pittsburgh	PROPN
cajgh-231	22	14	as	as	ADP
cajgh-231	22	15	part	part	NOUN
cajgh-231	22	16	of	of	ADP
cajgh-231	22	17	its	its	PRON
cajgh-231	22	18	d	d	NOUN
cajgh-231	22	19	-	-	PUNCT
cajgh-231	22	20	scribe	scribe	VERB
cajgh-231	22	21	digital	digital	ADJ
cajgh-231	22	22	publishing	publishing	NOUN
cajgh-231	22	23	program	program	NOUN
cajgh-231	22	24	and	and	CCONJ
cajgh-231	22	25	is	be	AUX
cajgh-231	22	26	cosponsored	cosponsor	VERB
cajgh-231	22	27	by	by	ADP
cajgh-231	22	28	the	the	DET
cajgh-231	22	29	university	university	PROPN
cajgh-231	22	30	of	of	ADP
cajgh-231	22	31	pittsburgh	pittsburgh	PROPN
cajgh-231	22	32	press	press	NOUN
cajgh-231	22	33	.	.	PUNCT
cajgh-231	23	1	central	central	ADJ
cajgh-231	23	2	asian	asian	ADJ
cajgh-231	23	3	journal	journal	NOUN
cajgh-231	23	4	of	of	ADP
cajgh-231	23	5	global	global	ADJ
cajgh-231	23	6	health	health	NOUN
cajgh-231	23	7	volume	volume	NOUN
cajgh-231	23	8	4	4	NUM
cajgh-231	23	9	,	,	PUNCT
cajgh-231	23	10	no	no	INTJ
cajgh-231	23	11	.	.	NOUN
cajgh-231	23	12	1	1	NUM
cajgh-231	23	13	(	(	PUNCT
cajgh-231	23	14	2015	2015	NUM
cajgh-231	23	15	)	)	PUNCT
cajgh-231	23	16	|	|	ADV
cajgh-231	23	17	issn	issn	VERB
cajgh-231	23	18	2166	2166	NUM
cajgh-231	23	19	-	-	SYM
cajgh-231	23	20	7403	7403	NUM
cajgh-231	23	21	(	(	PUNCT
cajgh-231	23	22	online	online	ADJ
cajgh-231	23	23	)	)	PUNCT
cajgh-231	23	24	|	|	ADV
cajgh-231	23	25	doi	doi	X
cajgh-231	23	26	10.5195	10.5195	NUM
cajgh-231	23	27	/	/	SYM
cajgh-231	23	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	23	29	and	and	CCONJ
cajgh-231	23	30	neurites	neurite	NOUN
cajgh-231	23	31	of	of	ADP
cajgh-231	23	32	pd	pd	PROPN
cajgh-231	23	33	patient	patient	NOUN
cajgh-231	23	34	neurons	neuron	NOUN
cajgh-231	23	35	.	.	PUNCT
cajgh-231	24	1	their	their	PRON
cajgh-231	24	2	major	major	ADJ
cajgh-231	24	3	constituent	constituent	NOUN
cajgh-231	24	4	is	be	AUX
cajgh-231	24	5	the	the	DET
cajgh-231	24	6	protein	protein	NOUN
cajgh-231	24	7	alpha	alpha	NOUN
cajgh-231	24	8	-	-	PUNCT
cajgh-231	24	9	synuclein	synuclein	NOUN
cajgh-231	24	10	.	.	PUNCT
cajgh-231	25	1	familial	familial	ADJ
cajgh-231	25	2	genetic	genetic	ADJ
cajgh-231	25	3	linkage	linkage	NOUN
cajgh-231	25	4	studies	study	NOUN
cajgh-231	25	5	have	have	AUX
cajgh-231	25	6	unequivocally	unequivocally	ADV
cajgh-231	25	7	associated	associate	VERB
cajgh-231	25	8	six	six	NUM
cajgh-231	25	9	genes	gene	NOUN
cajgh-231	25	10	with	with	ADP
cajgh-231	25	11	mendelian	mendelian	ADJ
cajgh-231	25	12	inheritable	inheritable	ADJ
cajgh-231	25	13	forms	form	NOUN
cajgh-231	25	14	of	of	ADP
cajgh-231	25	15	pd.4	pd.4	NOUN
cajgh-231	25	16	still	still	ADV
cajgh-231	25	17	,	,	PUNCT
cajgh-231	25	18	these	these	DET
cajgh-231	25	19	individual	individual	ADJ
cajgh-231	25	20	gene	gene	NOUN
cajgh-231	25	21	mutations	mutation	NOUN
cajgh-231	25	22	account	account	VERB
cajgh-231	25	23	for	for	ADP
cajgh-231	25	24	fewer	few	ADJ
cajgh-231	25	25	than	than	ADP
cajgh-231	25	26	10	10	NUM
cajgh-231	25	27	%	%	NOUN
cajgh-231	25	28	of	of	ADP
cajgh-231	25	29	pd	pd	NOUN
cajgh-231	25	30	cases	case	NOUN
cajgh-231	25	31	.	.	PUNCT
cajgh-231	26	1	they	they	PRON
cajgh-231	26	2	generally	generally	ADV
cajgh-231	26	3	lead	lead	VERB
cajgh-231	26	4	to	to	ADP
cajgh-231	26	5	juvenile	juvenile	ADJ
cajgh-231	26	6	or	or	CCONJ
cajgh-231	26	7	early	early	ADJ
cajgh-231	26	8	onset	onset	VERB
cajgh-231	26	9	pd	pd	NOUN
cajgh-231	26	10	(	(	PUNCT
cajgh-231	26	11	before	before	ADP
cajgh-231	26	12	50	50	NUM
cajgh-231	26	13	years	year	NOUN
cajgh-231	26	14	of	of	ADP
cajgh-231	26	15	age	age	NOUN
cajgh-231	26	16	)	)	PUNCT
cajgh-231	26	17	.	.	PUNCT
cajgh-231	27	1	naturally	naturally	ADV
cajgh-231	27	2	,	,	PUNCT
cajgh-231	27	3	genetics	genetic	NOUN
cajgh-231	27	4	still	still	ADV
cajgh-231	27	5	impacts	impact	VERB
cajgh-231	27	6	the	the	DET
cajgh-231	27	7	risk	risk	NOUN
cajgh-231	27	8	of	of	ADP
cajgh-231	27	9	an	an	DET
cajgh-231	27	10	individual	individual	ADJ
cajgh-231	27	11	acquiring	acquire	VERB
cajgh-231	27	12	nonmonogenic	nonmonogenic	ADJ
cajgh-231	27	13	sporadic	sporadic	ADJ
cajgh-231	27	14	pd	pd	PROPN
cajgh-231	27	15	later	later	ADV
cajgh-231	27	16	in	in	ADP
cajgh-231	27	17	life	life	NOUN
cajgh-231	27	18	.	.	PUNCT
cajgh-231	28	1	over	over	ADP
cajgh-231	28	2	a	a	DET
cajgh-231	28	3	dozen	dozen	NOUN
cajgh-231	28	4	single	single	ADJ
cajgh-231	28	5	nucleotide	nucleotide	NOUN
cajgh-231	28	6	polymorphisms	polymorphism	NOUN
cajgh-231	28	7	(	(	PUNCT
cajgh-231	28	8	snps	snps	PROPN
cajgh-231	28	9	)	)	PUNCT
cajgh-231	28	10	have	have	AUX
cajgh-231	28	11	been	be	AUX
cajgh-231	28	12	statistically	statistically	ADV
cajgh-231	28	13	linked	link	VERB
cajgh-231	28	14	with	with	ADP
cajgh-231	28	15	sporadic	sporadic	ADJ
cajgh-231	28	16	pd	pd	PROPN
cajgh-231	28	17	through	through	ADP
cajgh-231	28	18	genomewide	genomewide	PROPN
cajgh-231	28	19	association	association	NOUN
cajgh-231	28	20	studies	study	NOUN
cajgh-231	28	21	(	(	PUNCT
cajgh-231	28	22	gwass).5,6	gwass).5,6	NOUN
cajgh-231	28	23	however	however	ADV
cajgh-231	28	24	,	,	PUNCT
cajgh-231	28	25	the	the	DET
cajgh-231	28	26	differential	differential	ADJ
cajgh-231	28	27	risks	risk	NOUN
cajgh-231	28	28	associated	associate	VERB
cajgh-231	28	29	with	with	ADP
cajgh-231	28	30	carrying	carry	VERB
cajgh-231	28	31	these	these	DET
cajgh-231	28	32	snps	snps	NOUN
cajgh-231	28	33	,	,	PUNCT
cajgh-231	28	34	although	although	SCONJ
cajgh-231	28	35	statistically	statistically	ADV
cajgh-231	28	36	significant	significant	ADJ
cajgh-231	28	37	,	,	PUNCT
cajgh-231	28	38	are	be	AUX
cajgh-231	28	39	mostly	mostly	ADV
cajgh-231	28	40	very	very	ADV
cajgh-231	28	41	small	small	ADJ
cajgh-231	28	42	in	in	ADP
cajgh-231	28	43	absolute	absolute	ADJ
cajgh-231	28	44	terms	term	NOUN
cajgh-231	28	45	.	.	PUNCT
cajgh-231	29	1	similarly	similarly	ADV
cajgh-231	29	2	,	,	PUNCT
cajgh-231	29	3	although	although	SCONJ
cajgh-231	29	4	some	some	DET
cajgh-231	29	5	environmental	environmental	ADJ
cajgh-231	29	6	factors	factor	NOUN
cajgh-231	29	7	,	,	PUNCT
cajgh-231	29	8	such	such	ADJ
cajgh-231	29	9	as	as	ADP
cajgh-231	29	10	exposure	exposure	NOUN
cajgh-231	29	11	to	to	ADP
cajgh-231	29	12	metals	metal	NOUN
cajgh-231	29	13	or	or	CCONJ
cajgh-231	29	14	pesticides	pesticide	NOUN
cajgh-231	29	15	,	,	PUNCT
cajgh-231	29	16	have	have	AUX
cajgh-231	29	17	been	be	AUX
cajgh-231	29	18	statistically	statistically	ADV
cajgh-231	29	19	linked	link	VERB
cajgh-231	29	20	with	with	ADP
cajgh-231	29	21	pd	pd	PROPN
cajgh-231	29	22	,	,	PUNCT
cajgh-231	29	23	the	the	DET
cajgh-231	29	24	associations	association	NOUN
cajgh-231	29	25	do	do	AUX
cajgh-231	29	26	not	not	PART
cajgh-231	29	27	appear	appear	VERB
cajgh-231	29	28	to	to	PART
cajgh-231	29	29	be	be	AUX
cajgh-231	29	30	sufficiently	sufficiently	ADV
cajgh-231	29	31	widespread	widespread	ADJ
cajgh-231	29	32	to	to	PART
cajgh-231	29	33	explain	explain	VERB
cajgh-231	29	34	beyond	beyond	ADP
cajgh-231	29	35	a	a	DET
cajgh-231	29	36	minority	minority	NOUN
cajgh-231	29	37	of	of	ADP
cajgh-231	29	38	pd	pd	PROPN
cajgh-231	29	39	cases.7	cases.7	VERB
cajgh-231	29	40	thus	thus	ADV
cajgh-231	29	41	,	,	PUNCT
cajgh-231	29	42	the	the	DET
cajgh-231	29	43	etiology	etiology	NOUN
cajgh-231	29	44	of	of	ADP
cajgh-231	29	45	the	the	DET
cajgh-231	29	46	over	over	ADP
cajgh-231	29	47	90	90	NUM
cajgh-231	29	48	%	%	NOUN
cajgh-231	29	49	of	of	ADP
cajgh-231	29	50	cases	case	NOUN
cajgh-231	29	51	classified	classify	VERB
cajgh-231	29	52	as	as	SCONJ
cajgh-231	29	53	sporadic	sporadic	ADJ
cajgh-231	29	54	pd	pd	PROPN
cajgh-231	29	55	remains	remain	VERB
cajgh-231	29	56	undetermined	undetermined	ADJ
cajgh-231	29	57	.	.	PUNCT
cajgh-231	30	1	we	we	PRON
cajgh-231	30	2	briefly	briefly	ADV
cajgh-231	30	3	highlight	highlight	VERB
cajgh-231	30	4	some	some	PRON
cajgh-231	30	5	of	of	ADP
cajgh-231	30	6	the	the	DET
cajgh-231	30	7	major	major	ADJ
cajgh-231	30	8	theories	theory	NOUN
cajgh-231	30	9	being	be	AUX
cajgh-231	30	10	pursued	pursue	VERB
cajgh-231	30	11	regarding	regard	VERB
cajgh-231	30	12	the	the	DET
cajgh-231	30	13	nature	nature	NOUN
cajgh-231	30	14	of	of	ADP
cajgh-231	30	15	sporadic	sporadic	ADJ
cajgh-231	30	16	pd	pd	PROPN
cajgh-231	30	17	.	.	PUNCT
cajgh-231	31	1	different	different	ADJ
cajgh-231	31	2	aspects	aspect	NOUN
cajgh-231	31	3	of	of	ADP
cajgh-231	31	4	these	these	DET
cajgh-231	31	5	hypotheses	hypothesis	NOUN
cajgh-231	31	6	will	will	AUX
cajgh-231	31	7	be	be	AUX
cajgh-231	31	8	presented	present	VERB
cajgh-231	31	9	in	in	ADP
cajgh-231	31	10	more	more	ADJ
cajgh-231	31	11	detail	detail	NOUN
cajgh-231	31	12	as	as	ADP
cajgh-231	31	13	relevant	relevant	ADJ
cajgh-231	31	14	,	,	PUNCT
cajgh-231	31	15	throughout	throughout	ADP
cajgh-231	31	16	the	the	DET
cajgh-231	31	17	article	article	NOUN
cajgh-231	31	18	.	.	PUNCT
cajgh-231	32	1	an	an	DET
cajgh-231	32	2	overarching	overarching	ADJ
cajgh-231	32	3	hypothesis	hypothesis	NOUN
cajgh-231	32	4	on	on	ADP
cajgh-231	32	5	the	the	DET
cajgh-231	32	6	etiology	etiology	NOUN
cajgh-231	32	7	of	of	ADP
cajgh-231	32	8	sporadic	sporadic	ADJ
cajgh-231	32	9	pd	pd	PROPN
cajgh-231	32	10	is	be	AUX
cajgh-231	32	11	that	that	SCONJ
cajgh-231	32	12	it	it	PRON
cajgh-231	32	13	is	be	AUX
cajgh-231	32	14	triggered	trigger	VERB
cajgh-231	32	15	by	by	ADP
cajgh-231	32	16	an	an	DET
cajgh-231	32	17	external	external	ADJ
cajgh-231	32	18	agent	agent	NOUN
cajgh-231	32	19	.	.	PUNCT
cajgh-231	33	1	pesticides	pesticide	NOUN
cajgh-231	33	2	and	and	CCONJ
cajgh-231	33	3	metals	metal	NOUN
cajgh-231	33	4	would	would	AUX
cajgh-231	33	5	be	be	AUX
cajgh-231	33	6	two	two	NUM
cajgh-231	33	7	candidate	candidate	NOUN
cajgh-231	33	8	environmental	environmental	ADJ
cajgh-231	33	9	agents	agent	NOUN
cajgh-231	33	10	,	,	PUNCT
cajgh-231	33	11	given	give	VERB
cajgh-231	33	12	their	their	PRON
cajgh-231	33	13	statistical	statistical	ADJ
cajgh-231	33	14	association	association	NOUN
cajgh-231	33	15	with	with	ADP
cajgh-231	33	16	pd.7	pd.7	NOUN
cajgh-231	33	17	another	another	DET
cajgh-231	33	18	proposed	propose	VERB
cajgh-231	33	19	factor	factor	NOUN
cajgh-231	33	20	suggested	suggest	VERB
cajgh-231	33	21	in	in	ADP
cajgh-231	33	22	the	the	DET
cajgh-231	33	23	literature	literature	NOUN
cajgh-231	33	24	is	be	AUX
cajgh-231	33	25	a	a	DET
cajgh-231	33	26	neurothropic	neurothropic	ADJ
cajgh-231	33	27	pathogen	pathogen	NOUN
cajgh-231	33	28	,	,	PUNCT
cajgh-231	33	29	such	such	ADJ
cajgh-231	33	30	as	as	ADP
cajgh-231	33	31	a	a	DET
cajgh-231	33	32	virus8	virus8	NOUN
cajgh-231	33	33	or	or	CCONJ
cajgh-231	33	34	a	a	DET
cajgh-231	33	35	prion	prion	NOUN
cajgh-231	33	36	-	-	PUNCT
cajgh-231	33	37	like	like	ADJ
cajgh-231	33	38	protein.9	protein.9	NOUN
cajgh-231	33	39	entry	entry	NOUN
cajgh-231	33	40	into	into	ADP
cajgh-231	33	41	the	the	DET
cajgh-231	33	42	organism	organism	NOUN
cajgh-231	33	43	could	could	AUX
cajgh-231	33	44	be	be	AUX
cajgh-231	33	45	via	via	ADP
cajgh-231	33	46	the	the	DET
cajgh-231	33	47	peripheral	peripheral	ADJ
cajgh-231	33	48	olfactory	olfactory	ADJ
cajgh-231	33	49	system10	system10	NOUN
cajgh-231	33	50	or	or	CCONJ
cajgh-231	33	51	via	via	ADP
cajgh-231	33	52	the	the	DET
cajgh-231	33	53	gastrointestinal	gastrointestinal	ADJ
cajgh-231	33	54	tract,11	tract,11	NOUN
cajgh-231	33	55	two	two	NUM
cajgh-231	33	56	sites	site	NOUN
cajgh-231	33	57	associated	associate	VERB
cajgh-231	33	58	with	with	ADP
cajgh-231	33	59	early	early	ADJ
cajgh-231	33	60	prodromal	prodromal	ADJ
cajgh-231	33	61	clinical	clinical	ADJ
cajgh-231	33	62	symptoms	symptom	NOUN
cajgh-231	33	63	of	of	ADP
cajgh-231	33	64	pd	pd	PROPN
cajgh-231	33	65	.	.	PUNCT
cajgh-231	34	1	these	these	DET
cajgh-231	34	2	two	two	NUM
cajgh-231	34	3	sites	site	NOUN
cajgh-231	34	4	have	have	AUX
cajgh-231	34	5	also	also	ADV
cajgh-231	34	6	been	be	AUX
cajgh-231	34	7	combined	combine	VERB
cajgh-231	34	8	into	into	ADP
cajgh-231	34	9	a	a	DET
cajgh-231	34	10	dual	dual	ADV
cajgh-231	34	11	-	-	PUNCT
cajgh-231	34	12	hit	hit	VERB
cajgh-231	34	13	hypothesis	hypothesis	NOUN
cajgh-231	34	14	,	,	PUNCT
cajgh-231	34	15	centered	center	VERB
cajgh-231	34	16	on	on	ADP
cajgh-231	34	17	an	an	DET
cajgh-231	34	18	external	external	ADJ
cajgh-231	34	19	agent	agent	NOUN
cajgh-231	34	20	simultaneously	simultaneously	ADV
cajgh-231	34	21	entering	enter	VERB
cajgh-231	34	22	the	the	DET
cajgh-231	34	23	organism	organism	NOUN
cajgh-231	34	24	via	via	ADP
cajgh-231	34	25	the	the	DET
cajgh-231	34	26	two	two	NUM
cajgh-231	34	27	routes.12	routes.12	NOUN
cajgh-231	34	28	whether	whether	SCONJ
cajgh-231	34	29	with	with	ADP
cajgh-231	34	30	an	an	DET
cajgh-231	34	31	initially	initially	ADV
cajgh-231	34	32	external	external	ADJ
cajgh-231	34	33	origin	origin	NOUN
cajgh-231	34	34	or	or	CCONJ
cajgh-231	34	35	endogenously	endogenously	ADV
cajgh-231	34	36	generated	generate	VERB
cajgh-231	34	37	,	,	PUNCT
cajgh-231	34	38	the	the	DET
cajgh-231	34	39	theory	theory	NOUN
cajgh-231	34	40	that	that	SCONJ
cajgh-231	34	41	a	a	DET
cajgh-231	34	42	misfolded	misfolde	VERB
cajgh-231	34	43	,	,	PUNCT
cajgh-231	34	44	prion	prion	NOUN
cajgh-231	34	45	-	-	PUNCT
cajgh-231	34	46	like	like	ADJ
cajgh-231	34	47	self	self	NOUN
cajgh-231	34	48	-	-	PUNCT
cajgh-231	34	49	propagating	propagate	VERB
cajgh-231	34	50	form	form	NOUN
cajgh-231	34	51	of	of	ADP
cajgh-231	34	52	alphasynuclein	alphasynuclein	NOUN
cajgh-231	34	53	is	be	AUX
cajgh-231	34	54	responsible	responsible	ADJ
cajgh-231	34	55	for	for	ADP
cajgh-231	34	56	the	the	DET
cajgh-231	34	57	disease	disease	NOUN
cajgh-231	34	58	is	be	AUX
cajgh-231	34	59	another	another	DET
cajgh-231	34	60	major	major	ADJ
cajgh-231	34	61	hypothesis	hypothesis	NOUN
cajgh-231	34	62	currently	currently	ADV
cajgh-231	34	63	under	under	ADP
cajgh-231	34	64	investigation.9,13	investigation.9,13	NOUN
cajgh-231	34	65	more	more	ADV
cajgh-231	34	66	endogenous	endogenous	ADJ
cajgh-231	34	67	,	,	PUNCT
cajgh-231	34	68	aging	age	VERB
cajgh-231	34	69	-	-	PUNCT
cajgh-231	34	70	related	relate	VERB
cajgh-231	34	71	perspectives	perspective	NOUN
cajgh-231	34	72	of	of	ADP
cajgh-231	34	73	sporadic	sporadic	ADJ
cajgh-231	34	74	pd	pd	ADJ
cajgh-231	34	75	focus	focus	NOUN
cajgh-231	34	76	on	on	ADP
cajgh-231	34	77	the	the	DET
cajgh-231	34	78	role	role	NOUN
cajgh-231	34	79	of	of	ADP
cajgh-231	34	80	oxidative	oxidative	ADJ
cajgh-231	34	81	stress	stress	NOUN
cajgh-231	34	82	and	and	CCONJ
cajgh-231	34	83	mitochondrial	mitochondrial	ADJ
cajgh-231	34	84	damage	damage	NOUN
cajgh-231	34	85	,	,	PUNCT
cajgh-231	34	86	for	for	ADP
cajgh-231	34	87	which	which	PRON
cajgh-231	34	88	there	there	PRON
cajgh-231	34	89	is	be	VERB
cajgh-231	34	90	significant	significant	ADJ
cajgh-231	34	91	evidence	evidence	NOUN
cajgh-231	34	92	in	in	ADP
cajgh-231	34	93	pd	pd	PROPN
cajgh-231	34	94	patients	patient	NOUN
cajgh-231	34	95	.	.	PUNCT
cajgh-231	35	1	14,15	14,15	NUM
cajgh-231	35	2	finally	finally	ADV
cajgh-231	35	3	,	,	PUNCT
cajgh-231	35	4	although	although	SCONJ
cajgh-231	35	5	the	the	DET
cajgh-231	35	6	view	view	NOUN
cajgh-231	35	7	of	of	ADP
cajgh-231	35	8	sporadic	sporadic	ADJ
cajgh-231	35	9	pd	pd	PROPN
cajgh-231	35	10	as	as	ADP
cajgh-231	35	11	an	an	DET
cajgh-231	35	12	autoimmune	autoimmune	ADJ
cajgh-231	35	13	disease	disease	NOUN
cajgh-231	35	14	is	be	AUX
cajgh-231	35	15	not	not	PART
cajgh-231	35	16	typical	typical	ADJ
cajgh-231	35	17	,	,	PUNCT
cajgh-231	35	18	the	the	DET
cajgh-231	35	19	aggravating	aggravating	ADJ
cajgh-231	35	20	contribution	contribution	NOUN
cajgh-231	35	21	of	of	ADP
cajgh-231	35	22	the	the	DET
cajgh-231	35	23	neuro	neuro	NOUN
cajgh-231	35	24	-	-	PUNCT
cajgh-231	35	25	inflammatory	inflammatory	ADJ
cajgh-231	35	26	response	response	NOUN
cajgh-231	35	27	to	to	ADP
cajgh-231	35	28	the	the	DET
cajgh-231	35	29	disease	disease	NOUN
cajgh-231	35	30	is	be	AUX
cajgh-231	35	31	commonly	commonly	ADV
cajgh-231	35	32	acknowledged.16,17	acknowledged.16,17	ADJ
cajgh-231	35	33	starting	start	VERB
cajgh-231	35	34	from	from	ADP
cajgh-231	35	35	the	the	DET
cajgh-231	35	36	analysis	analysis	NOUN
cajgh-231	35	37	of	of	ADP
cajgh-231	35	38	sporadic	sporadic	ADJ
cajgh-231	35	39	pd	pd	NOUN
cajgh-231	35	40	blood	blood	NOUN
cajgh-231	35	41	gene	gene	NOUN
cajgh-231	35	42	-	-	PUNCT
cajgh-231	35	43	expression	expression	NOUN
cajgh-231	35	44	data	datum	NOUN
cajgh-231	35	45	,	,	PUNCT
cajgh-231	35	46	we	we	PRON
cajgh-231	35	47	have	have	AUX
cajgh-231	35	48	previously	previously	ADV
cajgh-231	35	49	argued	argue	VERB
cajgh-231	35	50	that	that	SCONJ
cajgh-231	35	51	sporadic	sporadic	ADJ
cajgh-231	35	52	pd	pd	PROPN
cajgh-231	35	53	could	could	AUX
cajgh-231	35	54	have	have	VERB
cajgh-231	35	55	a	a	DET
cajgh-231	35	56	hematopoietic	hematopoietic	ADJ
cajgh-231	35	57	origin.18	origin.18	NOUN
cajgh-231	35	58	in	in	ADP
cajgh-231	35	59	the	the	DET
cajgh-231	35	60	present	present	ADJ
cajgh-231	35	61	article	article	NOUN
cajgh-231	35	62	,	,	PUNCT
cajgh-231	35	63	we	we	PRON
cajgh-231	35	64	review	review	VERB
cajgh-231	35	65	and	and	CCONJ
cajgh-231	35	66	expand	expand	VERB
cajgh-231	35	67	on	on	ADP
cajgh-231	35	68	this	this	DET
cajgh-231	35	69	original	original	ADJ
cajgh-231	35	70	hypothesis	hypothesis	NOUN
cajgh-231	35	71	,	,	PUNCT
cajgh-231	35	72	placing	place	VERB
cajgh-231	35	73	it	it	PRON
cajgh-231	35	74	in	in	ADP
cajgh-231	35	75	the	the	DET
cajgh-231	35	76	context	context	NOUN
cajgh-231	35	77	of	of	ADP
cajgh-231	35	78	recent	recent	ADJ
cajgh-231	35	79	developments	development	NOUN
cajgh-231	35	80	in	in	ADP
cajgh-231	35	81	both	both	DET
cajgh-231	35	82	pd	pd	PROPN
cajgh-231	35	83	and	and	CCONJ
cajgh-231	35	84	the	the	DET
cajgh-231	35	85	broader	broad	ADJ
cajgh-231	35	86	biological	biological	ADJ
cajgh-231	35	87	research	research	NOUN
cajgh-231	35	88	.	.	PUNCT
cajgh-231	36	1	the	the	DET
cajgh-231	36	2	article	article	NOUN
cajgh-231	36	3	first	first	ADV
cajgh-231	36	4	addresses	address	NOUN
cajgh-231	36	5	why	why	SCONJ
cajgh-231	36	6	sporadic	sporadic	ADJ
cajgh-231	36	7	pd	pd	PROPN
cajgh-231	36	8	may	may	AUX
cajgh-231	36	9	be	be	AUX
cajgh-231	36	10	a	a	DET
cajgh-231	36	11	systemic	systemic	ADJ
cajgh-231	36	12	,	,	PUNCT
cajgh-231	36	13	rather	rather	ADV
cajgh-231	36	14	than	than	ADP
cajgh-231	36	15	solely	solely	ADV
cajgh-231	36	16	neuronal	neuronal	ADJ
cajgh-231	36	17	,	,	PUNCT
cajgh-231	36	18	condition	condition	NOUN
cajgh-231	36	19	.	.	PUNCT
cajgh-231	37	1	then	then	ADV
cajgh-231	37	2	,	,	PUNCT
cajgh-231	37	3	it	it	PRON
cajgh-231	37	4	discusses	discuss	VERB
cajgh-231	37	5	why	why	SCONJ
cajgh-231	37	6	inter	inter	ADJ
cajgh-231	37	7	-	-	ADJ
cajgh-231	37	8	cellular	cellular	ADJ
cajgh-231	37	9	propagation	propagation	NOUN
cajgh-231	37	10	of	of	ADP
cajgh-231	37	11	the	the	DET
cajgh-231	37	12	pathology	pathology	NOUN
cajgh-231	37	13	may	may	AUX
cajgh-231	37	14	be	be	AUX
cajgh-231	37	15	involved	involve	VERB
cajgh-231	37	16	,	,	PUNCT
cajgh-231	37	17	rather	rather	ADV
cajgh-231	37	18	than	than	SCONJ
cajgh-231	37	19	the	the	DET
cajgh-231	37	20	pathology	pathology	NOUN
cajgh-231	37	21	being	be	AUX
cajgh-231	37	22	purely	purely	ADV
cajgh-231	37	23	associated	associate	VERB
cajgh-231	37	24	with	with	ADP
cajgh-231	37	25	cell	cell	NOUN
cajgh-231	37	26	ageing	age	VERB
cajgh-231	37	27	phenomena	phenomenon	NOUN
cajgh-231	37	28	.	.	PUNCT
cajgh-231	38	1	in	in	ADP
cajgh-231	38	2	particular	particular	ADJ
cajgh-231	38	3	,	,	PUNCT
cajgh-231	38	4	we	we	PRON
cajgh-231	38	5	present	present	VERB
cajgh-231	38	6	the	the	DET
cajgh-231	38	7	possibility	possibility	NOUN
cajgh-231	38	8	that	that	SCONJ
cajgh-231	38	9	the	the	DET
cajgh-231	38	10	disease	disease	NOUN
cajgh-231	38	11	transmission	transmission	NOUN
cajgh-231	38	12	may	may	AUX
cajgh-231	38	13	be	be	AUX
cajgh-231	38	14	enabled	enable	VERB
cajgh-231	38	15	by	by	ADP
cajgh-231	38	16	the	the	DET
cajgh-231	38	17	inter	inter	ADJ
cajgh-231	38	18	-	-	ADJ
cajgh-231	38	19	cellular	cellular	ADJ
cajgh-231	38	20	exchange	exchange	NOUN
cajgh-231	38	21	of	of	ADP
cajgh-231	38	22	the	the	DET
cajgh-231	38	23	mitochondrial	mitochondrial	ADJ
cajgh-231	38	24	dna	dna	NOUN
cajgh-231	38	25	.	.	PUNCT
cajgh-231	39	1	finally	finally	ADV
cajgh-231	39	2	,	,	PUNCT
cajgh-231	39	3	the	the	DET
cajgh-231	39	4	article	article	NOUN
cajgh-231	39	5	revisits	revisit	VERB
cajgh-231	39	6	our	our	PRON
cajgh-231	39	7	previously	previously	ADV
cajgh-231	39	8	published	publish	VERB
cajgh-231	39	9	hypothesis	hypothesis	NOUN
cajgh-231	39	10	that	that	PRON
cajgh-231	39	11	the	the	DET
cajgh-231	39	12	pathology	pathology	NOUN
cajgh-231	39	13	may	may	AUX
cajgh-231	39	14	initially	initially	ADV
cajgh-231	39	15	begin	begin	VERB
cajgh-231	39	16	at	at	ADP
cajgh-231	39	17	hematopoiesis	hematopoiesis	NOUN
cajgh-231	39	18	.	.	PUNCT
cajgh-231	40	1	the	the	DET
cajgh-231	40	2	universal	universal	ADJ
cajgh-231	40	3	nature	nature	NOUN
cajgh-231	40	4	of	of	ADP
cajgh-231	40	5	the	the	DET
cajgh-231	40	6	pd	pd	NOUN
cajgh-231	40	7	-	-	NOUN
cajgh-231	40	8	state	state	NOUN
cajgh-231	40	9	in	in	ADP
cajgh-231	40	10	this	this	DET
cajgh-231	40	11	section	section	NOUN
cajgh-231	40	12	,	,	PUNCT
cajgh-231	40	13	we	we	PRON
cajgh-231	40	14	argue	argue	VERB
cajgh-231	40	15	for	for	ADP
cajgh-231	40	16	the	the	DET
cajgh-231	40	17	systemic	systemic	ADJ
cajgh-231	40	18	nature	nature	NOUN
cajgh-231	40	19	of	of	ADP
cajgh-231	40	20	sporadic	sporadic	ADJ
cajgh-231	40	21	pd	pd	PROPN
cajgh-231	40	22	.	.	PUNCT
cajgh-231	41	1	our	our	PRON
cajgh-231	41	2	case	case	NOUN
cajgh-231	41	3	is	be	AUX
cajgh-231	41	4	centered	center	VERB
cajgh-231	41	5	on	on	ADP
cajgh-231	41	6	the	the	DET
cajgh-231	41	7	interpretation	interpretation	NOUN
cajgh-231	41	8	of	of	ADP
cajgh-231	41	9	recently	recently	ADV
cajgh-231	41	10	published	publish	VERB
cajgh-231	41	11	evidence	evidence	NOUN
cajgh-231	41	12	obtained	obtain	VERB
cajgh-231	41	13	by	by	ADP
cajgh-231	41	14	applying	apply	VERB
cajgh-231	41	15	induced	induced	ADJ
cajgh-231	41	16	pluripotent	pluripotent	ADJ
cajgh-231	41	17	stem	stem	NOUN
cajgh-231	41	18	cell	cell	NOUN
cajgh-231	41	19	(	(	PUNCT
cajgh-231	41	20	ipsc	ipsc	NOUN
cajgh-231	41	21	)	)	PUNCT
cajgh-231	41	22	technology	technology	NOUN
cajgh-231	41	23	to	to	ADP
cajgh-231	41	24	pd	pd	PROPN
cajgh-231	41	25	research.19,20	research.19,20	PROPN
cajgh-231	41	26	using	use	VERB
cajgh-231	41	27	ipsc	ipsc	NOUN
cajgh-231	41	28	techniques	technique	NOUN
cajgh-231	41	29	,	,	PUNCT
cajgh-231	41	30	conveniently	conveniently	ADV
cajgh-231	41	31	collected	collect	VERB
cajgh-231	41	32	cells	cell	NOUN
cajgh-231	41	33	from	from	ADP
cajgh-231	41	34	pd	pd	PROPN
cajgh-231	41	35	patients	patient	NOUN
cajgh-231	41	36	,	,	PUNCT
cajgh-231	41	37	such	such	ADJ
cajgh-231	41	38	as	as	ADP
cajgh-231	41	39	skin	skin	NOUN
cajgh-231	41	40	fibroblasts	fibroblast	NOUN
cajgh-231	41	41	,	,	PUNCT
cajgh-231	41	42	can	can	AUX
cajgh-231	41	43	be	be	AUX
cajgh-231	41	44	reverted	revert	VERB
cajgh-231	41	45	to	to	ADP
cajgh-231	41	46	a	a	DET
cajgh-231	41	47	pluripotent	pluripotent	ADJ
cajgh-231	41	48	state	state	NOUN
cajgh-231	41	49	and	and	CCONJ
cajgh-231	41	50	subsequently	subsequently	ADV
cajgh-231	41	51	differentiated	differentiate	VERB
cajgh-231	41	52	into	into	ADP
cajgh-231	41	53	dopaminergic	dopaminergic	ADJ
cajgh-231	41	54	neurons	neuron	NOUN
cajgh-231	41	55	.	.	PUNCT
cajgh-231	42	1	we	we	PRON
cajgh-231	42	2	believe	believe	VERB
cajgh-231	42	3	that	that	SCONJ
cajgh-231	42	4	early	early	PROPN
cajgh-231	42	5	pd	pd	PROPN
cajgh-231	42	6	ipsc	ipsc	PROPN
cajgh-231	42	7	experimental	experimental	PROPN
cajgh-231	42	8	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	42	9	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	42	10	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	42	11	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	42	12	valente	valente	NOUN
cajgh-231	42	13	this	this	DET
cajgh-231	42	14	work	work	NOUN
cajgh-231	42	15	is	be	AUX
cajgh-231	42	16	licensed	license	VERB
cajgh-231	42	17	under	under	ADP
cajgh-231	42	18	a	a	DET
cajgh-231	42	19	creative	creative	ADJ
cajgh-231	42	20	commons	common	NOUN
cajgh-231	42	21	attribution	attribution	NOUN
cajgh-231	42	22	4.0	4.0	NUM
cajgh-231	42	23	united	unite	VERB
cajgh-231	42	24	states	states	PROPN
cajgh-231	42	25	license	license	NOUN
cajgh-231	42	26	.	.	PUNCT
cajgh-231	43	1	this	this	DET
cajgh-231	43	2	journal	journal	NOUN
cajgh-231	43	3	is	be	AUX
cajgh-231	43	4	published	publish	VERB
cajgh-231	43	5	by	by	ADP
cajgh-231	43	6	theuniversity	theuniversity	NOUN
cajgh-231	43	7	library	library	NOUN
cajgh-231	43	8	system	system	NOUN
cajgh-231	43	9	of	of	ADP
cajgh-231	43	10	the	the	DET
cajgh-231	43	11	university	university	PROPN
cajgh-231	43	12	of	of	ADP
cajgh-231	43	13	pittsburgh	pittsburgh	PROPN
cajgh-231	43	14	as	as	ADP
cajgh-231	43	15	part	part	NOUN
cajgh-231	43	16	of	of	ADP
cajgh-231	43	17	its	its	PRON
cajgh-231	43	18	d	d	NOUN
cajgh-231	43	19	-	-	PUNCT
cajgh-231	43	20	scribe	scribe	VERB
cajgh-231	43	21	digital	digital	ADJ
cajgh-231	43	22	publishing	publishing	NOUN
cajgh-231	43	23	program	program	NOUN
cajgh-231	43	24	and	and	CCONJ
cajgh-231	43	25	is	be	AUX
cajgh-231	43	26	cosponsored	cosponsor	VERB
cajgh-231	43	27	by	by	ADP
cajgh-231	43	28	the	the	DET
cajgh-231	43	29	university	university	PROPN
cajgh-231	43	30	of	of	ADP
cajgh-231	43	31	pittsburgh	pittsburgh	PROPN
cajgh-231	43	32	press	press	NOUN
cajgh-231	43	33	.	.	PUNCT
cajgh-231	44	1	central	central	ADJ
cajgh-231	44	2	asian	asian	ADJ
cajgh-231	44	3	journal	journal	NOUN
cajgh-231	44	4	of	of	ADP
cajgh-231	44	5	global	global	ADJ
cajgh-231	44	6	health	health	NOUN
cajgh-231	44	7	volume	volume	NOUN
cajgh-231	44	8	4	4	NUM
cajgh-231	44	9	,	,	PUNCT
cajgh-231	44	10	no	no	INTJ
cajgh-231	44	11	.	.	NOUN
cajgh-231	44	12	1	1	NUM
cajgh-231	44	13	(	(	PUNCT
cajgh-231	44	14	2015	2015	NUM
cajgh-231	44	15	)	)	PUNCT
cajgh-231	44	16	|	|	ADV
cajgh-231	44	17	issn	issn	VERB
cajgh-231	44	18	2166	2166	NUM
cajgh-231	44	19	-	-	SYM
cajgh-231	44	20	7403	7403	NUM
cajgh-231	44	21	(	(	PUNCT
cajgh-231	44	22	online	online	ADJ
cajgh-231	44	23	)	)	PUNCT
cajgh-231	44	24	|	|	ADV
cajgh-231	44	25	doi	doi	X
cajgh-231	44	26	10.5195	10.5195	NUM
cajgh-231	44	27	/	/	SYM
cajgh-231	44	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	44	29	results	result	NOUN
cajgh-231	44	30	support	support	VERB
cajgh-231	44	31	a	a	DET
cajgh-231	44	32	fundamental	fundamental	ADJ
cajgh-231	44	33	re	re	NOUN
cajgh-231	44	34	-	-	NOUN
cajgh-231	44	35	evaluation	evaluation	NOUN
cajgh-231	44	36	of	of	ADP
cajgh-231	44	37	the	the	DET
cajgh-231	44	38	nature	nature	NOUN
cajgh-231	44	39	of	of	ADP
cajgh-231	44	40	the	the	DET
cajgh-231	44	41	sporadic	sporadic	ADJ
cajgh-231	44	42	non	non	ADJ
cajgh-231	44	43	-	-	ADJ
cajgh-231	44	44	monogenic	monogenic	ADJ
cajgh-231	44	45	form	form	NOUN
cajgh-231	44	46	of	of	ADP
cajgh-231	44	47	the	the	DET
cajgh-231	44	48	disease	disease	NOUN
cajgh-231	44	49	.	.	PUNCT
cajgh-231	45	1	we	we	PRON
cajgh-231	45	2	summarize	summarize	VERB
cajgh-231	45	3	the	the	DET
cajgh-231	45	4	main	main	ADJ
cajgh-231	45	5	observations	observation	NOUN
cajgh-231	45	6	from	from	ADP
cajgh-231	45	7	two	two	NUM
cajgh-231	45	8	of	of	ADP
cajgh-231	45	9	the	the	DET
cajgh-231	45	10	published	publish	VERB
cajgh-231	45	11	pd	pd	PROPN
cajgh-231	45	12	ipsc	ipsc	PROPN
cajgh-231	45	13	studies.19,20	studies.19,20	PROPN
cajgh-231	45	14	in	in	ADP
cajgh-231	45	15	both	both	DET
cajgh-231	45	16	studies	study	NOUN
cajgh-231	45	17	,	,	PUNCT
cajgh-231	45	18	skin	skin	NOUN
cajgh-231	45	19	fibroblasts	fibroblast	NOUN
cajgh-231	45	20	from	from	ADP
cajgh-231	45	21	sporadic	sporadic	ADJ
cajgh-231	45	22	pd	pd	NOUN
cajgh-231	45	23	patients	patient	NOUN
cajgh-231	45	24	(	(	PUNCT
cajgh-231	45	25	presuppose	presuppose	VERB
cajgh-231	45	26	sporadic	sporadic	ADJ
cajgh-231	45	27	henceforth	henceforth	ADV
cajgh-231	45	28	)	)	PUNCT
cajgh-231	45	29	were	be	AUX
cajgh-231	45	30	reprogrammed	reprogramme	VERB
cajgh-231	45	31	back	back	ADV
cajgh-231	45	32	into	into	ADP
cajgh-231	45	33	pluripotent	pluripotent	ADJ
cajgh-231	45	34	stem	stem	NOUN
cajgh-231	45	35	cells	cell	NOUN
cajgh-231	45	36	,	,	PUNCT
cajgh-231	45	37	which	which	PRON
cajgh-231	45	38	were	be	AUX
cajgh-231	45	39	then	then	ADV
cajgh-231	45	40	differentiated	differentiate	VERB
cajgh-231	45	41	into	into	ADP
cajgh-231	45	42	dopaminergic	dopaminergic	ADJ
cajgh-231	45	43	neurons	neuron	NOUN
cajgh-231	45	44	.	.	PUNCT
cajgh-231	46	1	sánchez	sánchez	NOUN
cajgh-231	46	2	-	-	PUNCT
cajgh-231	46	3	danés	danés	PROPN
cajgh-231	46	4	et	et	NOUN
cajgh-231	46	5	al.19	al.19	NOUN
cajgh-231	46	6	reported	report	VERB
cajgh-231	46	7	that	that	SCONJ
cajgh-231	46	8	,	,	PUNCT
cajgh-231	46	9	in	in	ADP
cajgh-231	46	10	comparison	comparison	NOUN
cajgh-231	46	11	with	with	ADP
cajgh-231	46	12	neurons	neuron	NOUN
cajgh-231	46	13	derived	derive	VERB
cajgh-231	46	14	from	from	ADP
cajgh-231	46	15	fibroblasts	fibroblast	NOUN
cajgh-231	46	16	from	from	ADP
cajgh-231	46	17	disease	disease	NOUN
cajgh-231	46	18	-	-	PUNCT
cajgh-231	46	19	free	free	ADJ
cajgh-231	46	20	controls	control	NOUN
cajgh-231	46	21	,	,	PUNCT
cajgh-231	46	22	neurons	neuron	NOUN
cajgh-231	46	23	originating	originate	VERB
cajgh-231	46	24	in	in	ADP
cajgh-231	46	25	fibroblasts	fibroblast	NOUN
cajgh-231	46	26	from	from	ADP
cajgh-231	46	27	pd	pd	PROPN
cajgh-231	46	28	patients	patient	NOUN
cajgh-231	46	29	consistently	consistently	ADV
cajgh-231	46	30	showed	show	VERB
cajgh-231	46	31	pd	pd	NOUN
cajgh-231	46	32	phenotype	phenotype	NOUN
cajgh-231	46	33	associated	associate	VERB
cajgh-231	46	34	alterations	alteration	NOUN
cajgh-231	46	35	.	.	PUNCT
cajgh-231	47	1	these	these	PRON
cajgh-231	47	2	included	include	VERB
cajgh-231	47	3	reduced	reduced	ADJ
cajgh-231	47	4	numbers	number	NOUN
cajgh-231	47	5	of	of	ADP
cajgh-231	47	6	neurites	neurite	NOUN
cajgh-231	47	7	,	,	PUNCT
cajgh-231	47	8	more	more	ADV
cajgh-231	47	9	limited	limited	ADJ
cajgh-231	47	10	neurite	neurite	NOUN
cajgh-231	47	11	arborizations	arborization	NOUN
cajgh-231	47	12	,	,	PUNCT
cajgh-231	47	13	and	and	CCONJ
cajgh-231	47	14	increases	increase	NOUN
cajgh-231	47	15	in	in	ADP
cajgh-231	47	16	caspase-3	caspase-3	NUM
cajgh-231	47	17	activity	activity	NOUN
cajgh-231	47	18	,	,	PUNCT
cajgh-231	47	19	a	a	DET
cajgh-231	47	20	marker	marker	NOUN
cajgh-231	47	21	for	for	ADP
cajgh-231	47	22	cell	cell	NOUN
cajgh-231	47	23	apoptosis	apoptosis	NOUN
cajgh-231	47	24	.	.	PUNCT
cajgh-231	48	1	woodard	woodard	PROPN
cajgh-231	48	2	et	et	PROPN
cajgh-231	48	3	al.20	al.20	PROPN
cajgh-231	48	4	utilized	utilize	VERB
cajgh-231	48	5	neurons	neuron	NOUN
cajgh-231	48	6	derived	derive	VERB
cajgh-231	48	7	from	from	ADP
cajgh-231	48	8	fibroblasts	fibroblast	NOUN
cajgh-231	48	9	of	of	ADP
cajgh-231	48	10	two	two	NUM
cajgh-231	48	11	monozygotic	monozygotic	ADJ
cajgh-231	48	12	twins	twin	NOUN
cajgh-231	48	13	discordant	discordant	ADJ
cajgh-231	48	14	for	for	ADP
cajgh-231	48	15	pd	pd	PROPN
cajgh-231	48	16	.	.	PROPN
cajgh-231	48	17	multiple	multiple	ADJ
cajgh-231	48	18	alterations	alteration	NOUN
cajgh-231	48	19	that	that	PRON
cajgh-231	48	20	can	can	AUX
cajgh-231	48	21	be	be	AUX
cajgh-231	48	22	linked	link	VERB
cajgh-231	48	23	with	with	ADP
cajgh-231	48	24	a	a	DET
cajgh-231	48	25	pd	pd	NOUN
cajgh-231	48	26	phenotype	phenotype	NOUN
cajgh-231	48	27	were	be	AUX
cajgh-231	48	28	present	present	ADJ
cajgh-231	48	29	exclusively	exclusively	ADV
cajgh-231	48	30	in	in	ADP
cajgh-231	48	31	the	the	DET
cajgh-231	48	32	fibroblasts	fibroblast	NOUN
cajgh-231	48	33	derived	derive	VERB
cajgh-231	48	34	from	from	ADP
cajgh-231	48	35	the	the	DET
cajgh-231	48	36	pd	pd	PROPN
cajgh-231	48	37	twin	twin	PROPN
cajgh-231	48	38	.	.	PUNCT
cajgh-231	49	1	these	these	PRON
cajgh-231	49	2	included	include	VERB
cajgh-231	49	3	lower	low	ADJ
cajgh-231	49	4	dopamine	dopamine	NOUN
cajgh-231	49	5	levels	level	NOUN
cajgh-231	49	6	,	,	PUNCT
cajgh-231	49	7	an	an	DET
cajgh-231	49	8	elevation	elevation	NOUN
cajgh-231	49	9	of	of	ADP
cajgh-231	49	10	alpha	alpha	NOUN
cajgh-231	49	11	-	-	PUNCT
cajgh-231	49	12	synuclein	synuclein	NOUN
cajgh-231	49	13	in	in	ADP
cajgh-231	49	14	neurites	neurite	NOUN
cajgh-231	49	15	,	,	PUNCT
cajgh-231	49	16	a	a	DET
cajgh-231	49	17	delay	delay	NOUN
cajgh-231	49	18	in	in	ADP
cajgh-231	49	19	the	the	DET
cajgh-231	49	20	emergence	emergence	NOUN
cajgh-231	49	21	of	of	ADP
cajgh-231	49	22	spontaneous	spontaneous	ADJ
cajgh-231	49	23	action	action	NOUN
cajgh-231	49	24	potentials	potential	VERB
cajgh-231	49	25	,	,	PUNCT
cajgh-231	49	26	and	and	CCONJ
cajgh-231	49	27	an	an	DET
cajgh-231	49	28	absence	absence	NOUN
cajgh-231	49	29	of	of	ADP
cajgh-231	49	30	synchronous	synchronous	ADJ
cajgh-231	49	31	neuronal	neuronal	ADJ
cajgh-231	49	32	activity	activity	NOUN
cajgh-231	49	33	.	.	PUNCT
cajgh-231	50	1	an	an	DET
cajgh-231	50	2	epidemiological	epidemiological	ADJ
cajgh-231	50	3	study	study	NOUN
cajgh-231	50	4	by	by	ADP
cajgh-231	50	5	tanner	tanner	NOUN
cajgh-231	50	6	et	et	PROPN
cajgh-231	50	7	al.21	al.21	PROPN
cajgh-231	50	8	reported	report	VERB
cajgh-231	50	9	a	a	DET
cajgh-231	50	10	mere	mere	ADJ
cajgh-231	50	11	15.5	15.5	NUM
cajgh-231	50	12	%	%	NOUN
cajgh-231	50	13	concordance	concordance	NOUN
cajgh-231	50	14	of	of	ADP
cajgh-231	50	15	monozygotic	monozygotic	ADJ
cajgh-231	50	16	twins	twin	NOUN
cajgh-231	50	17	in	in	ADP
cajgh-231	50	18	developing	develop	VERB
cajgh-231	50	19	pd	pd	PROPN
cajgh-231	50	20	.	.	PUNCT
cajgh-231	51	1	an	an	DET
cajgh-231	51	2	analogous	analogous	ADJ
cajgh-231	51	3	study	study	NOUN
cajgh-231	51	4	in	in	ADP
cajgh-231	51	5	sweden	sweden	PROPN
cajgh-231	51	6	published	publish	VERB
cajgh-231	51	7	by	by	ADP
cajgh-231	51	8	wirdefeldt	wirdefeldt	PROPN
cajgh-231	51	9	et	et	PROPN
cajgh-231	51	10	al.22	al.22	PROPN
cajgh-231	51	11	corroborated	corroborate	VERB
cajgh-231	51	12	this	this	DET
cajgh-231	51	13	result	result	NOUN
cajgh-231	51	14	,	,	PUNCT
cajgh-231	51	15	placing	place	VERB
cajgh-231	51	16	the	the	DET
cajgh-231	51	17	concordance	concordance	NOUN
cajgh-231	51	18	rate	rate	NOUN
cajgh-231	51	19	at	at	ADP
cajgh-231	51	20	11	11	NUM
cajgh-231	51	21	%	%	NOUN
cajgh-231	51	22	.	.	PUNCT
cajgh-231	52	1	thus	thus	ADV
cajgh-231	52	2	,	,	PUNCT
cajgh-231	52	3	excluding	exclude	VERB
cajgh-231	52	4	the	the	DET
cajgh-231	52	5	monogenic	monogenic	ADJ
cajgh-231	52	6	cases	case	NOUN
cajgh-231	52	7	,	,	PUNCT
cajgh-231	52	8	heredity	heredity	NOUN
cajgh-231	52	9	does	do	AUX
cajgh-231	52	10	not	not	PART
cajgh-231	52	11	ensure	ensure	VERB
cajgh-231	52	12	the	the	DET
cajgh-231	52	13	emergence	emergence	NOUN
cajgh-231	52	14	of	of	ADP
cajgh-231	52	15	pd	pd	PROPN
cajgh-231	52	16	.	.	PUNCT
cajgh-231	53	1	therefore	therefore	ADV
cajgh-231	53	2	,	,	PUNCT
cajgh-231	53	3	the	the	DET
cajgh-231	53	4	consistent	consistent	ADJ
cajgh-231	53	5	,	,	PUNCT
cajgh-231	53	6	regular	regular	ADJ
cajgh-231	53	7	emergence	emergence	NOUN
cajgh-231	53	8	of	of	ADP
cajgh-231	53	9	a	a	DET
cajgh-231	53	10	pd	pd	NOUN
cajgh-231	53	11	phenotype	phenotype	NOUN
cajgh-231	53	12	in	in	ADP
cajgh-231	53	13	neurons	neuron	NOUN
cajgh-231	53	14	derived	derive	VERB
cajgh-231	53	15	from	from	ADP
cajgh-231	53	16	fibroblasts	fibroblast	NOUN
cajgh-231	53	17	from	from	ADP
cajgh-231	53	18	pd	pd	PROPN
cajgh-231	53	19	patients	patient	NOUN
cajgh-231	53	20	can	can	AUX
cajgh-231	53	21	not	not	PART
cajgh-231	53	22	be	be	AUX
cajgh-231	53	23	attributed	attribute	VERB
cajgh-231	53	24	to	to	ADP
cajgh-231	53	25	a	a	DET
cajgh-231	53	26	pd	pd	PROPN
cajgh-231	53	27	favorable	favorable	ADJ
cajgh-231	53	28	germline	germline	NOUN
cajgh-231	53	29	genetic	genetic	ADJ
cajgh-231	53	30	background	background	NOUN
cajgh-231	53	31	in	in	ADP
cajgh-231	53	32	the	the	DET
cajgh-231	53	33	patients	patient	NOUN
cajgh-231	53	34	.	.	PUNCT
cajgh-231	54	1	the	the	DET
cajgh-231	54	2	conclusion	conclusion	NOUN
cajgh-231	54	3	is	be	AUX
cajgh-231	54	4	that	that	SCONJ
cajgh-231	54	5	the	the	DET
cajgh-231	54	6	disease	disease	NOUN
cajgh-231	54	7	must	must	AUX
cajgh-231	54	8	have	have	AUX
cajgh-231	54	9	been	be	AUX
cajgh-231	54	10	present	present	ADJ
cajgh-231	54	11	in	in	ADP
cajgh-231	54	12	the	the	DET
cajgh-231	54	13	skin	skin	NOUN
cajgh-231	54	14	fibroblasts	fibroblast	NOUN
cajgh-231	54	15	from	from	ADP
cajgh-231	54	16	the	the	DET
cajgh-231	54	17	patients	patient	NOUN
cajgh-231	54	18	.	.	PUNCT
cajgh-231	55	1	pd	pd	PROPN
cajgh-231	55	2	is	be	AUX
cajgh-231	55	3	thus	thus	ADV
cajgh-231	55	4	a	a	DET
cajgh-231	55	5	systemic	systemic	ADJ
cajgh-231	55	6	condition	condition	NOUN
cajgh-231	55	7	,	,	PUNCT
cajgh-231	55	8	not	not	PART
cajgh-231	55	9	confined	confine	VERB
cajgh-231	55	10	to	to	ADP
cajgh-231	55	11	neuronal	neuronal	ADJ
cajgh-231	55	12	cells	cell	NOUN
cajgh-231	55	13	.	.	PUNCT
cajgh-231	56	1	we	we	PRON
cajgh-231	56	2	propose	propose	VERB
cajgh-231	56	3	to	to	PART
cajgh-231	56	4	characterize	characterize	VERB
cajgh-231	56	5	pd	pd	PROPN
cajgh-231	56	6	as	as	ADP
cajgh-231	56	7	a	a	DET
cajgh-231	56	8	pathological	pathological	ADJ
cajgh-231	56	9	deviation	deviation	NOUN
cajgh-231	56	10	in	in	ADP
cajgh-231	56	11	the	the	DET
cajgh-231	56	12	expression	expression	NOUN
cajgh-231	56	13	program	program	NOUN
cajgh-231	56	14	of	of	ADP
cajgh-231	56	15	a	a	DET
cajgh-231	56	16	cell	cell	NOUN
cajgh-231	56	17	:	:	PUNCT
cajgh-231	56	18	the	the	DET
cajgh-231	56	19	pd	pd	PROPN
cajgh-231	56	20	expression	expression	NOUN
cajgh-231	56	21	-	-	PUNCT
cajgh-231	56	22	state	state	NOUN
cajgh-231	56	23	,	,	PUNCT
cajgh-231	56	24	or	or	CCONJ
cajgh-231	56	25	pd	pd	NOUN
cajgh-231	56	26	-	-	NOUN
cajgh-231	56	27	state	state	NOUN
cajgh-231	56	28	for	for	ADP
cajgh-231	56	29	short.18,23	short.18,23	NOUN
cajgh-231	56	30	reports	report	NOUN
cajgh-231	56	31	of	of	ADP
cajgh-231	56	32	a	a	DET
cajgh-231	56	33	characteristic	characteristic	ADJ
cajgh-231	56	34	pd	pd	NOUN
cajgh-231	56	35	gene	gene	NOUN
cajgh-231	56	36	-	-	PUNCT
cajgh-231	56	37	expression	expression	NOUN
cajgh-231	56	38	signature	signature	NOUN
cajgh-231	56	39	across	across	ADP
cajgh-231	56	40	multiple	multiple	ADJ
cajgh-231	56	41	tissues	tissue	NOUN
cajgh-231	56	42	support	support	VERB
cajgh-231	56	43	this	this	DET
cajgh-231	56	44	view.18,24	view.18,24	NOUN
cajgh-231	56	45	-	-	PUNCT
cajgh-231	56	46	26	26	NUM
cajgh-231	56	47	the	the	DET
cajgh-231	56	48	recent	recent	ADJ
cajgh-231	56	49	observation	observation	NOUN
cajgh-231	56	50	of	of	ADP
cajgh-231	56	51	a	a	DET
cajgh-231	56	52	unique	unique	ADJ
cajgh-231	56	53	,	,	PUNCT
cajgh-231	56	54	concordant	concordant	ADJ
cajgh-231	56	55	pattern	pattern	NOUN
cajgh-231	56	56	of	of	ADP
cajgh-231	56	57	methylation	methylation	NOUN
cajgh-231	56	58	in	in	ADP
cajgh-231	56	59	post	post	ADJ
cajgh-231	56	60	-	-	ADJ
cajgh-231	56	61	mortem	mortem	ADJ
cajgh-231	56	62	frontal	frontal	ADJ
cajgh-231	56	63	cortex	cortex	NOUN
cajgh-231	56	64	samples	sample	NOUN
cajgh-231	56	65	and	and	CCONJ
cajgh-231	56	66	peripheral	peripheral	ADJ
cajgh-231	56	67	blood	blood	NOUN
cajgh-231	56	68	leukocytes	leukocyte	VERB
cajgh-231	56	69	from	from	ADP
cajgh-231	56	70	pd	pd	NOUN
cajgh-231	56	71	patients27	patients27	NOUN
cajgh-231	56	72	reinforces	reinforce	VERB
cajgh-231	56	73	this	this	DET
cajgh-231	56	74	standpoint	standpoint	NOUN
cajgh-231	56	75	,	,	PUNCT
cajgh-231	56	76	further	far	ADV
cajgh-231	56	77	suggesting	suggest	VERB
cajgh-231	56	78	that	that	SCONJ
cajgh-231	56	79	the	the	DET
cajgh-231	56	80	pd	pd	PROPN
cajgh-231	56	81	-	-	PUNCT
cajgh-231	56	82	state	state	NOUN
cajgh-231	56	83	may	may	AUX
cajgh-231	56	84	be	be	AUX
cajgh-231	56	85	stabilized	stabilize	VERB
cajgh-231	56	86	by	by	ADP
cajgh-231	56	87	dna	dna	PROPN
cajgh-231	56	88	epigenetic	epigenetic	ADJ
cajgh-231	56	89	modifications	modification	NOUN
cajgh-231	56	90	.	.	PUNCT
cajgh-231	57	1	the	the	DET
cajgh-231	57	2	role	role	NOUN
cajgh-231	57	3	of	of	ADP
cajgh-231	57	4	ageing	ageing	NOUN
cajgh-231	57	5	in	in	ADP
cajgh-231	57	6	pd	pd	PROPN
cajgh-231	57	7	in	in	ADP
cajgh-231	57	8	spite	spite	NOUN
cajgh-231	57	9	of	of	ADP
cajgh-231	57	10	possessing	possess	VERB
cajgh-231	57	11	a	a	DET
cajgh-231	57	12	multitude	multitude	NOUN
cajgh-231	57	13	of	of	ADP
cajgh-231	57	14	self	self	NOUN
cajgh-231	57	15	-	-	PUNCT
cajgh-231	57	16	repair	repair	NOUN
cajgh-231	57	17	mechanisms	mechanism	NOUN
cajgh-231	57	18	,	,	PUNCT
cajgh-231	57	19	all	all	DET
cajgh-231	57	20	cells	cell	NOUN
cajgh-231	57	21	undergo	undergo	VERB
cajgh-231	57	22	the	the	DET
cajgh-231	57	23	ageing	age	VERB
cajgh-231	57	24	process.28	process.28	NOUN
cajgh-231	57	25	they	they	PRON
cajgh-231	57	26	gradually	gradually	ADV
cajgh-231	57	27	accumulate	accumulate	VERB
cajgh-231	57	28	dysfunctional	dysfunctional	ADJ
cajgh-231	57	29	molecules	molecule	NOUN
cajgh-231	57	30	,	,	PUNCT
cajgh-231	57	31	as	as	ADV
cajgh-231	57	32	well	well	ADV
cajgh-231	57	33	as	as	ADP
cajgh-231	57	34	random	random	ADJ
cajgh-231	57	35	mutations	mutation	NOUN
cajgh-231	57	36	and	and	CCONJ
cajgh-231	57	37	other	other	ADJ
cajgh-231	57	38	assorted	assorted	ADJ
cajgh-231	57	39	alterations	alteration	NOUN
cajgh-231	57	40	in	in	ADP
cajgh-231	57	41	their	their	PRON
cajgh-231	57	42	genetic	genetic	ADJ
cajgh-231	57	43	code	code	NOUN
cajgh-231	57	44	,	,	PUNCT
cajgh-231	57	45	ultimately	ultimately	ADV
cajgh-231	57	46	resulting	result	VERB
cajgh-231	57	47	in	in	ADP
cajgh-231	57	48	the	the	DET
cajgh-231	57	49	ageing	age	VERB
cajgh-231	57	50	phenotype	phenotype	NOUN
cajgh-231	57	51	.	.	PUNCT
cajgh-231	58	1	as	as	ADP
cajgh-231	58	2	a	a	DET
cajgh-231	58	3	source	source	NOUN
cajgh-231	58	4	of	of	ADP
cajgh-231	58	5	free	free	ADJ
cajgh-231	58	6	radicals	radical	NOUN
cajgh-231	58	7	,	,	PUNCT
cajgh-231	58	8	mitochondria	mitochondria	NOUN
cajgh-231	58	9	and	and	CCONJ
cajgh-231	58	10	the	the	DET
cajgh-231	58	11	mitochondrial	mitochondrial	ADJ
cajgh-231	58	12	dna	dna	NOUN
cajgh-231	58	13	are	be	AUX
cajgh-231	58	14	particularly	particularly	ADV
cajgh-231	58	15	vulnerable	vulnerable	ADJ
cajgh-231	58	16	to	to	ADP
cajgh-231	58	17	oxidative	oxidative	ADJ
cajgh-231	58	18	stress	stress	NOUN
cajgh-231	58	19	damage.29	damage.29	NOUN
cajgh-231	58	20	this	this	DET
cajgh-231	58	21	observation	observation	NOUN
cajgh-231	58	22	has	have	AUX
cajgh-231	58	23	led	lead	VERB
cajgh-231	58	24	to	to	ADP
cajgh-231	58	25	the	the	DET
cajgh-231	58	26	theory	theory	NOUN
cajgh-231	58	27	that	that	SCONJ
cajgh-231	58	28	the	the	DET
cajgh-231	58	29	mitochondrial	mitochondrial	ADJ
cajgh-231	58	30	dysfunction	dysfunction	NOUN
cajgh-231	58	31	caused	cause	VERB
cajgh-231	58	32	by	by	ADP
cajgh-231	58	33	oxidative	oxidative	ADJ
cajgh-231	58	34	stress	stress	NOUN
cajgh-231	58	35	plays	play	VERB
cajgh-231	58	36	a	a	DET
cajgh-231	58	37	central	central	ADJ
cajgh-231	58	38	role	role	NOUN
cajgh-231	58	39	in	in	ADP
cajgh-231	58	40	ageing.30,31	ageing.30,31	NOUN
cajgh-231	58	41	with	with	ADP
cajgh-231	58	42	pd	pd	NOUN
cajgh-231	58	43	arising	arise	VERB
cajgh-231	58	44	at	at	ADP
cajgh-231	58	45	old	old	ADJ
cajgh-231	58	46	age	age	NOUN
cajgh-231	58	47	and	and	CCONJ
cajgh-231	58	48	with	with	ADP
cajgh-231	58	49	mitochondrial	mitochondrial	ADJ
cajgh-231	58	50	function	function	NOUN
cajgh-231	58	51	specifically	specifically	ADV
cajgh-231	58	52	known	know	VERB
cajgh-231	58	53	to	to	PART
cajgh-231	58	54	be	be	AUX
cajgh-231	58	55	compromised	compromise	VERB
cajgh-231	58	56	in	in	ADP
cajgh-231	58	57	a	a	DET
cajgh-231	58	58	variety	variety	NOUN
cajgh-231	58	59	of	of	ADP
cajgh-231	58	60	cell	cell	NOUN
cajgh-231	58	61	types	type	NOUN
cajgh-231	58	62	in	in	ADP
cajgh-231	58	63	pd	pd	PROPN
cajgh-231	58	64	patients,32	patients,32	NOUN
cajgh-231	58	65	-	-	PUNCT
cajgh-231	58	66	35	35	NUM
cajgh-231	58	67	the	the	DET
cajgh-231	58	68	mitochondrial	mitochondrial	ADJ
cajgh-231	58	69	theory	theory	NOUN
cajgh-231	58	70	of	of	ADP
cajgh-231	58	71	aging	age	VERB
cajgh-231	58	72	broadly	broadly	ADV
cajgh-231	58	73	views	view	VERB
cajgh-231	58	74	pd	pd	PROPN
cajgh-231	58	75	as	as	ADP
cajgh-231	58	76	yet	yet	ADV
cajgh-231	58	77	another	another	PRON
cajgh-231	58	78	manifestation	manifestation	NOUN
cajgh-231	58	79	of	of	ADP
cajgh-231	58	80	this	this	DET
cajgh-231	58	81	phenomenon.14	phenomenon.14	NOUN
cajgh-231	58	82	it	it	PRON
cajgh-231	58	83	is	be	AUX
cajgh-231	58	84	conceivable	conceivable	ADJ
cajgh-231	58	85	that	that	SCONJ
cajgh-231	58	86	accumulated	accumulate	VERB
cajgh-231	58	87	random	random	ADJ
cajgh-231	58	88	damage	damage	NOUN
cajgh-231	58	89	,	,	PUNCT
cajgh-231	58	90	possibly	possibly	ADV
cajgh-231	58	91	in	in	ADP
cajgh-231	58	92	mitochondrial	mitochondrial	ADJ
cajgh-231	58	93	dna	dna	NOUN
cajgh-231	58	94	and	and	CCONJ
cajgh-231	58	95	due	due	ADP
cajgh-231	58	96	to	to	ADP
cajgh-231	58	97	oxidative	oxidative	ADJ
cajgh-231	58	98	stress	stress	NOUN
cajgh-231	58	99	,	,	PUNCT
cajgh-231	58	100	eventually	eventually	ADV
cajgh-231	58	101	triggers	trigger	VERB
cajgh-231	58	102	the	the	DET
cajgh-231	58	103	gene	gene	NOUN
cajgh-231	58	104	expression	expression	NOUN
cajgh-231	58	105	program	program	NOUN
cajgh-231	58	106	of	of	ADP
cajgh-231	58	107	a	a	DET
cajgh-231	58	108	cell	cell	NOUN
cajgh-231	58	109	to	to	PART
cajgh-231	58	110	shift	shift	VERB
cajgh-231	58	111	to	to	ADP
cajgh-231	58	112	the	the	DET
cajgh-231	58	113	pd	pd	NOUN
cajgh-231	58	114	-	-	NOUN
cajgh-231	58	115	state	state	NOUN
cajgh-231	58	116	.	.	PUNCT
cajgh-231	59	1	this	this	DET
cajgh-231	59	2	shift	shift	NOUN
cajgh-231	59	3	to	to	ADP
cajgh-231	59	4	the	the	DET
cajgh-231	59	5	pd	pd	NOUN
cajgh-231	59	6	-	-	NOUN
cajgh-231	59	7	state	state	NOUN
cajgh-231	59	8	in	in	ADP
cajgh-231	59	9	a	a	DET
cajgh-231	59	10	cell	cell	NOUN
cajgh-231	59	11	could	could	AUX
cajgh-231	59	12	thus	thus	ADV
cajgh-231	59	13	be	be	AUX
cajgh-231	59	14	viewed	view	VERB
cajgh-231	59	15	as	as	ADP
cajgh-231	59	16	a	a	DET
cajgh-231	59	17	probabilistic	probabilistic	ADJ
cajgh-231	59	18	event	event	NOUN
cajgh-231	59	19	,	,	PUNCT
cajgh-231	59	20	its	its	PRON
cajgh-231	59	21	likelihood	likelihood	NOUN
cajgh-231	59	22	being	be	AUX
cajgh-231	59	23	a	a	DET
cajgh-231	59	24	(	(	PUNCT
cajgh-231	59	25	nonlinearly	nonlinearly	ADV
cajgh-231	59	26	)	)	PUNCT
cajgh-231	59	27	increasing	increase	VERB
cajgh-231	59	28	function	function	NOUN
cajgh-231	59	29	of	of	ADP
cajgh-231	59	30	the	the	DET
cajgh-231	59	31	accumulated	accumulate	VERB
cajgh-231	59	32	damage	damage	NOUN
cajgh-231	59	33	.	.	PUNCT
cajgh-231	60	1	however	however	ADV
cajgh-231	60	2	,	,	PUNCT
cajgh-231	60	3	we	we	PRON
cajgh-231	60	4	argue	argue	VERB
cajgh-231	60	5	that	that	SCONJ
cajgh-231	60	6	it	it	PRON
cajgh-231	60	7	is	be	AUX
cajgh-231	60	8	impossible	impossible	ADJ
cajgh-231	60	9	for	for	SCONJ
cajgh-231	60	10	all	all	DET
cajgh-231	60	11	the	the	DET
cajgh-231	60	12	pdstate	pdstate	ADJ
cajgh-231	60	13	cells	cell	NOUN
cajgh-231	60	14	in	in	ADP
cajgh-231	60	15	an	an	DET
cajgh-231	60	16	affected	affected	ADJ
cajgh-231	60	17	individual	individual	NOUN
cajgh-231	60	18	to	to	PART
cajgh-231	60	19	have	have	AUX
cajgh-231	60	20	acquired	acquire	VERB
cajgh-231	60	21	the	the	DET
cajgh-231	60	22	pd	pd	NOUN
cajgh-231	60	23	-	-	NOUN
cajgh-231	60	24	state	state	NOUN
cajgh-231	60	25	in	in	ADP
cajgh-231	60	26	this	this	DET
cajgh-231	60	27	fashion	fashion	NOUN
cajgh-231	60	28	.	.	PUNCT
cajgh-231	61	1	the	the	DET
cajgh-231	61	2	following	follow	VERB
cajgh-231	61	3	valid	valid	ADJ
cajgh-231	61	4	scenario	scenario	NOUN
cajgh-231	61	5	may	may	AUX
cajgh-231	61	6	be	be	AUX
cajgh-231	61	7	considered	consider	VERB
cajgh-231	61	8	.	.	PUNCT
cajgh-231	62	1	imagine	imagine	VERB
cajgh-231	62	2	two	two	NUM
cajgh-231	62	3	monozygotic	monozygotic	ADJ
cajgh-231	62	4	twins	twin	NOUN
cajgh-231	62	5	,	,	PUNCT
cajgh-231	62	6	one	one	NUM
cajgh-231	62	7	diagnosed	diagnose	VERB
cajgh-231	62	8	with	with	ADP
cajgh-231	62	9	pd	pd	PROPN
cajgh-231	62	10	in	in	ADP
cajgh-231	62	11	the	the	DET
cajgh-231	62	12	past	past	NOUN
cajgh-231	62	13	,	,	PUNCT
cajgh-231	62	14	with	with	ADP
cajgh-231	62	15	the	the	DET
cajgh-231	62	16	other	other	ADJ
cajgh-231	62	17	being	be	AUX
cajgh-231	62	18	disease	disease	NOUN
cajgh-231	62	19	-	-	PUNCT
cajgh-231	62	20	free	free	ADJ
cajgh-231	62	21	at	at	ADP
cajgh-231	62	22	the	the	DET
cajgh-231	62	23	present	present	ADJ
cajgh-231	62	24	time	time	NOUN
cajgh-231	62	25	.	.	PUNCT
cajgh-231	63	1	let	let	VERB
cajgh-231	63	2	the	the	DET
cajgh-231	63	3	unaffected	unaffected	ADJ
cajgh-231	63	4	twin	twin	ADJ
cajgh-231	63	5	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	63	6	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	63	7	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	63	8	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	63	9	central	central	ADJ
cajgh-231	63	10	asian	asian	ADJ
cajgh-231	63	11	journal	journal	NOUN
cajgh-231	63	12	of	of	ADP
cajgh-231	63	13	global	global	ADJ
cajgh-231	63	14	health	health	NOUN
cajgh-231	63	15	this	this	DET
cajgh-231	63	16	work	work	NOUN
cajgh-231	63	17	is	be	AUX
cajgh-231	63	18	licensed	license	VERB
cajgh-231	63	19	under	under	ADP
cajgh-231	63	20	a	a	DET
cajgh-231	63	21	creative	creative	ADJ
cajgh-231	63	22	commons	common	NOUN
cajgh-231	63	23	attribution	attribution	NOUN
cajgh-231	63	24	4.0	4.0	NUM
cajgh-231	63	25	united	unite	VERB
cajgh-231	63	26	states	states	PROPN
cajgh-231	63	27	license	license	NOUN
cajgh-231	63	28	.	.	PUNCT
cajgh-231	64	1	this	this	DET
cajgh-231	64	2	journal	journal	NOUN
cajgh-231	64	3	is	be	AUX
cajgh-231	64	4	published	publish	VERB
cajgh-231	64	5	by	by	ADP
cajgh-231	64	6	theuniversity	theuniversity	NOUN
cajgh-231	64	7	library	library	NOUN
cajgh-231	64	8	system	system	NOUN
cajgh-231	64	9	of	of	ADP
cajgh-231	64	10	the	the	DET
cajgh-231	64	11	university	university	PROPN
cajgh-231	64	12	of	of	ADP
cajgh-231	64	13	pittsburgh	pittsburgh	PROPN
cajgh-231	64	14	as	as	ADP
cajgh-231	64	15	part	part	NOUN
cajgh-231	64	16	of	of	ADP
cajgh-231	64	17	its	its	PRON
cajgh-231	64	18	d	d	NOUN
cajgh-231	64	19	-	-	PUNCT
cajgh-231	64	20	scribe	scribe	VERB
cajgh-231	64	21	digital	digital	ADJ
cajgh-231	64	22	publishing	publishing	NOUN
cajgh-231	64	23	program	program	NOUN
cajgh-231	64	24	and	and	CCONJ
cajgh-231	64	25	is	be	AUX
cajgh-231	64	26	cosponsored	cosponsor	VERB
cajgh-231	64	27	by	by	ADP
cajgh-231	64	28	the	the	DET
cajgh-231	64	29	university	university	PROPN
cajgh-231	64	30	of	of	ADP
cajgh-231	64	31	pittsburgh	pittsburgh	PROPN
cajgh-231	64	32	press	press	NOUN
cajgh-231	64	33	.	.	PUNCT
cajgh-231	65	1	central	central	ADJ
cajgh-231	65	2	asian	asian	ADJ
cajgh-231	65	3	journal	journal	NOUN
cajgh-231	65	4	of	of	ADP
cajgh-231	65	5	global	global	ADJ
cajgh-231	65	6	health	health	NOUN
cajgh-231	65	7	volume	volume	NOUN
cajgh-231	65	8	4	4	NUM
cajgh-231	65	9	,	,	PUNCT
cajgh-231	65	10	no	no	INTJ
cajgh-231	65	11	.	.	NOUN
cajgh-231	65	12	1	1	NUM
cajgh-231	65	13	(	(	PUNCT
cajgh-231	65	14	2015	2015	NUM
cajgh-231	65	15	)	)	PUNCT
cajgh-231	65	16	|	|	ADV
cajgh-231	65	17	issn	issn	VERB
cajgh-231	65	18	2166	2166	NUM
cajgh-231	65	19	-	-	SYM
cajgh-231	65	20	7403	7403	NUM
cajgh-231	65	21	(	(	PUNCT
cajgh-231	65	22	online	online	ADJ
cajgh-231	65	23	)	)	PUNCT
cajgh-231	65	24	|	|	ADV
cajgh-231	65	25	doi	doi	X
cajgh-231	65	26	10.5195	10.5195	NUM
cajgh-231	65	27	/	/	SYM
cajgh-231	65	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	65	29	presently	presently	ADV
cajgh-231	65	30	exhibit	exhibit	VERB
cajgh-231	65	31	a	a	DET
cajgh-231	65	32	greater	great	ADJ
cajgh-231	65	33	amount	amount	NOUN
cajgh-231	65	34	of	of	ADP
cajgh-231	65	35	age	age	NOUN
cajgh-231	65	36	accumulated	accumulate	VERB
cajgh-231	65	37	damage	damage	NOUN
cajgh-231	65	38	than	than	SCONJ
cajgh-231	65	39	the	the	DET
cajgh-231	65	40	affected	affected	ADJ
cajgh-231	65	41	twin	twin	NOUN
cajgh-231	65	42	did	do	VERB
cajgh-231	65	43	at	at	ADP
cajgh-231	65	44	the	the	DET
cajgh-231	65	45	time	time	NOUN
cajgh-231	65	46	of	of	ADP
cajgh-231	65	47	his	his	PRON
cajgh-231	65	48	pd	pd	NOUN
cajgh-231	65	49	diagnosis	diagnosis	NOUN
cajgh-231	65	50	–	–	PUNCT
cajgh-231	65	51	this	this	PRON
cajgh-231	65	52	would	would	AUX
cajgh-231	65	53	be	be	AUX
cajgh-231	65	54	the	the	DET
cajgh-231	65	55	case	case	NOUN
cajgh-231	65	56	given	give	VERB
cajgh-231	65	57	enough	enough	ADJ
cajgh-231	65	58	years	year	NOUN
cajgh-231	65	59	had	have	AUX
cajgh-231	65	60	elapsed	elapse	VERB
cajgh-231	65	61	since	since	SCONJ
cajgh-231	65	62	the	the	DET
cajgh-231	65	63	original	original	ADJ
cajgh-231	65	64	diagnosis	diagnosis	NOUN
cajgh-231	65	65	.	.	PUNCT
cajgh-231	66	1	now	now	ADV
cajgh-231	66	2	,	,	PUNCT
cajgh-231	66	3	assume	assume	VERB
cajgh-231	66	4	that	that	SCONJ
cajgh-231	66	5	accumulated	accumulate	VERB
cajgh-231	66	6	random	random	ADJ
cajgh-231	66	7	damage	damage	NOUN
cajgh-231	66	8	is	be	AUX
cajgh-231	66	9	the	the	DET
cajgh-231	66	10	only	only	ADJ
cajgh-231	66	11	possible	possible	ADJ
cajgh-231	66	12	trigger	trigger	NOUN
cajgh-231	66	13	of	of	ADP
cajgh-231	66	14	the	the	DET
cajgh-231	66	15	pd	pd	NOUN
cajgh-231	66	16	-	-	NOUN
cajgh-231	66	17	state	state	NOUN
cajgh-231	66	18	in	in	ADP
cajgh-231	66	19	a	a	DET
cajgh-231	66	20	cell	cell	NOUN
cajgh-231	66	21	.	.	PUNCT
cajgh-231	67	1	then	then	ADV
cajgh-231	67	2	,	,	PUNCT
cajgh-231	67	3	the	the	DET
cajgh-231	67	4	observed	observe	VERB
cajgh-231	67	5	greater	great	ADJ
cajgh-231	67	6	age	age	NOUN
cajgh-231	67	7	accumulated	accumulate	VERB
cajgh-231	67	8	damage	damage	NOUN
cajgh-231	67	9	in	in	ADP
cajgh-231	67	10	the	the	DET
cajgh-231	67	11	undiagnosed	undiagnosed	ADJ
cajgh-231	67	12	twin	twin	NOUN
cajgh-231	67	13	at	at	ADP
cajgh-231	67	14	present	present	NOUN
cajgh-231	67	15	would	would	AUX
cajgh-231	67	16	guarantee	guarantee	VERB
cajgh-231	67	17	a	a	DET
cajgh-231	67	18	currently	currently	ADV
cajgh-231	67	19	greater	great	ADJ
cajgh-231	67	20	probability	probability	NOUN
cajgh-231	67	21	for	for	SCONJ
cajgh-231	67	22	his	his	PRON
cajgh-231	67	23	or	or	CCONJ
cajgh-231	67	24	her	her	PRON
cajgh-231	67	25	individual	individual	ADJ
cajgh-231	67	26	cells	cell	NOUN
cajgh-231	67	27	to	to	PART
cajgh-231	67	28	acquire	acquire	VERB
cajgh-231	67	29	the	the	DET
cajgh-231	67	30	pd	pd	NOUN
cajgh-231	67	31	-	-	NOUN
cajgh-231	67	32	state	state	NOUN
cajgh-231	67	33	than	than	SCONJ
cajgh-231	67	34	that	that	DET
cajgh-231	67	35	probability	probability	NOUN
cajgh-231	67	36	was	be	AUX
cajgh-231	67	37	for	for	ADP
cajgh-231	67	38	the	the	DET
cajgh-231	67	39	cells	cell	NOUN
cajgh-231	67	40	of	of	ADP
cajgh-231	67	41	the	the	DET
cajgh-231	67	42	affected	affected	ADJ
cajgh-231	67	43	twin	twin	NOUN
cajgh-231	67	44	at	at	ADP
cajgh-231	67	45	the	the	DET
cajgh-231	67	46	time	time	NOUN
cajgh-231	67	47	of	of	ADP
cajgh-231	67	48	his	his	PRON
cajgh-231	67	49	pd	pd	NOUN
cajgh-231	67	50	-	-	NOUN
cajgh-231	67	51	diagnosis	diagnosis	NOUN
cajgh-231	67	52	.	.	PUNCT
cajgh-231	68	1	yet	yet	ADV
cajgh-231	68	2	,	,	PUNCT
cajgh-231	68	3	the	the	DET
cajgh-231	68	4	unaffected	unaffected	ADJ
cajgh-231	68	5	twin	twin	NOUN
cajgh-231	68	6	continues	continue	VERB
cajgh-231	68	7	to	to	PART
cajgh-231	68	8	show	show	VERB
cajgh-231	68	9	no	no	DET
cajgh-231	68	10	clinical	clinical	ADJ
cajgh-231	68	11	signs	sign	NOUN
cajgh-231	68	12	of	of	ADP
cajgh-231	68	13	pd	pd	PROPN
cajgh-231	68	14	at	at	ADP
cajgh-231	68	15	present	present	ADJ
cajgh-231	68	16	,	,	PUNCT
cajgh-231	68	17	in	in	ADP
cajgh-231	68	18	contrast	contrast	NOUN
cajgh-231	68	19	with	with	ADP
cajgh-231	68	20	the	the	DET
cajgh-231	68	21	affected	affected	ADJ
cajgh-231	68	22	twin	twin	NOUN
cajgh-231	68	23	at	at	ADP
cajgh-231	68	24	the	the	DET
cajgh-231	68	25	time	time	NOUN
cajgh-231	68	26	of	of	ADP
cajgh-231	68	27	his	his	PRON
cajgh-231	68	28	pd	pd	ADJ
cajgh-231	68	29	diagnosis	diagnosis	NOUN
cajgh-231	68	30	.	.	PUNCT
cajgh-231	69	1	thus	thus	ADV
cajgh-231	69	2	,	,	PUNCT
cajgh-231	69	3	assuming	assume	VERB
cajgh-231	69	4	that	that	SCONJ
cajgh-231	69	5	accumulated	accumulate	VERB
cajgh-231	69	6	random	random	ADJ
cajgh-231	69	7	damage	damage	NOUN
cajgh-231	69	8	is	be	AUX
cajgh-231	69	9	the	the	DET
cajgh-231	69	10	only	only	ADJ
cajgh-231	69	11	possible	possible	ADJ
cajgh-231	69	12	trigger	trigger	NOUN
cajgh-231	69	13	of	of	ADP
cajgh-231	69	14	the	the	DET
cajgh-231	69	15	pd	pd	NOUN
cajgh-231	69	16	-	-	NOUN
cajgh-231	69	17	state	state	NOUN
cajgh-231	69	18	in	in	ADP
cajgh-231	69	19	a	a	DET
cajgh-231	69	20	cell	cell	NOUN
cajgh-231	69	21	leads	lead	VERB
cajgh-231	69	22	to	to	ADP
cajgh-231	69	23	a	a	DET
cajgh-231	69	24	probabilistic	probabilistic	ADJ
cajgh-231	69	25	paradox	paradox	NOUN
cajgh-231	69	26	.	.	PUNCT
cajgh-231	70	1	we	we	PRON
cajgh-231	70	2	make	make	VERB
cajgh-231	70	3	two	two	NUM
cajgh-231	70	4	remarks	remark	NOUN
cajgh-231	70	5	on	on	ADP
cajgh-231	70	6	the	the	DET
cajgh-231	70	7	argument	argument	NOUN
cajgh-231	70	8	presented	present	VERB
cajgh-231	70	9	in	in	ADP
cajgh-231	70	10	the	the	DET
cajgh-231	70	11	previous	previous	ADJ
cajgh-231	70	12	paragraph	paragraph	NOUN
cajgh-231	70	13	.	.	PUNCT
cajgh-231	71	1	firstly	firstly	ADV
cajgh-231	71	2	,	,	PUNCT
cajgh-231	71	3	accumulated	accumulate	VERB
cajgh-231	71	4	random	random	ADJ
cajgh-231	71	5	damage	damage	NOUN
cajgh-231	71	6	causing	cause	VERB
cajgh-231	71	7	a	a	DET
cajgh-231	71	8	cell	cell	NOUN
cajgh-231	71	9	to	to	PART
cajgh-231	71	10	shift	shift	VERB
cajgh-231	71	11	to	to	ADP
cajgh-231	71	12	the	the	DET
cajgh-231	71	13	pd	pd	NOUN
cajgh-231	71	14	-	-	NOUN
cajgh-231	71	15	state	state	NOUN
cajgh-231	71	16	does	do	AUX
cajgh-231	71	17	not	not	PART
cajgh-231	71	18	pose	pose	VERB
cajgh-231	71	19	a	a	DET
cajgh-231	71	20	paradox	paradox	NOUN
cajgh-231	71	21	.	.	PUNCT
cajgh-231	72	1	only	only	ADV
cajgh-231	72	2	the	the	DET
cajgh-231	72	3	presence	presence	NOUN
cajgh-231	72	4	of	of	ADP
cajgh-231	72	5	most	most	ADJ
cajgh-231	72	6	of	of	ADP
cajgh-231	72	7	the	the	DET
cajgh-231	72	8	pd	pd	ADJ
cajgh-231	72	9	-	-	PUNCT
cajgh-231	72	10	state	state	NOUN
cajgh-231	72	11	cells	cell	NOUN
cajgh-231	72	12	in	in	ADP
cajgh-231	72	13	the	the	DET
cajgh-231	72	14	organism	organism	NOUN
cajgh-231	72	15	can	can	AUX
cajgh-231	72	16	not	not	PART
cajgh-231	72	17	be	be	AUX
cajgh-231	72	18	explained	explain	VERB
cajgh-231	72	19	by	by	ADP
cajgh-231	72	20	such	such	DET
cajgh-231	72	21	a	a	DET
cajgh-231	72	22	process	process	NOUN
cajgh-231	72	23	.	.	PUNCT
cajgh-231	73	1	therefore	therefore	ADV
cajgh-231	73	2	,	,	PUNCT
cajgh-231	73	3	ageingassociated	ageingassociated	ADJ
cajgh-231	73	4	damage	damage	NOUN
cajgh-231	73	5	,	,	PUNCT
cajgh-231	73	6	caused	cause	VERB
cajgh-231	73	7	by	by	ADP
cajgh-231	73	8	oxidative	oxidative	ADJ
cajgh-231	73	9	stress	stress	NOUN
cajgh-231	73	10	in	in	ADP
cajgh-231	73	11	mitochondria	mitochondria	NOUN
cajgh-231	73	12	,	,	PUNCT
cajgh-231	73	13	could	could	AUX
cajgh-231	73	14	still	still	ADV
cajgh-231	73	15	be	be	AUX
cajgh-231	73	16	the	the	DET
cajgh-231	73	17	trigger	trigger	NOUN
cajgh-231	73	18	for	for	ADP
cajgh-231	73	19	a	a	DET
cajgh-231	73	20	primordial	primordial	ADJ
cajgh-231	73	21	cell	cell	NOUN
cajgh-231	73	22	in	in	ADP
cajgh-231	73	23	the	the	DET
cajgh-231	73	24	organism	organism	NOUN
cajgh-231	73	25	to	to	PART
cajgh-231	73	26	shift	shift	VERB
cajgh-231	73	27	to	to	ADP
cajgh-231	73	28	the	the	DET
cajgh-231	73	29	pd	pd	NOUN
cajgh-231	73	30	-	-	NOUN
cajgh-231	73	31	state	state	NOUN
cajgh-231	73	32	.	.	PUNCT
cajgh-231	74	1	secondly	secondly	ADV
cajgh-231	74	2	,	,	PUNCT
cajgh-231	74	3	ageing	age	VERB
cajgh-231	74	4	-	-	PUNCT
cajgh-231	74	5	associated	associate	VERB
cajgh-231	74	6	cellular	cellular	ADJ
cajgh-231	74	7	damage	damage	NOUN
cajgh-231	74	8	may	may	AUX
cajgh-231	74	9	not	not	PART
cajgh-231	74	10	be	be	AUX
cajgh-231	74	11	required	require	VERB
cajgh-231	74	12	for	for	ADP
cajgh-231	74	13	the	the	DET
cajgh-231	74	14	subsequent	subsequent	ADJ
cajgh-231	74	15	dissemination	dissemination	NOUN
cajgh-231	74	16	of	of	ADP
cajgh-231	74	17	the	the	DET
cajgh-231	74	18	pd	pd	NOUN
cajgh-231	74	19	-	-	NOUN
cajgh-231	74	20	state	state	NOUN
cajgh-231	74	21	across	across	ADP
cajgh-231	74	22	the	the	DET
cajgh-231	74	23	organism	organism	NOUN
cajgh-231	74	24	since	since	SCONJ
cajgh-231	74	25	,	,	PUNCT
cajgh-231	74	26	as	as	SCONJ
cajgh-231	74	27	argued	argue	VERB
cajgh-231	74	28	,	,	PUNCT
cajgh-231	74	29	this	this	DET
cajgh-231	74	30	dissemination	dissemination	NOUN
cajgh-231	74	31	would	would	AUX
cajgh-231	74	32	occur	occur	VERB
cajgh-231	74	33	via	via	ADP
cajgh-231	74	34	a	a	DET
cajgh-231	74	35	distinct	distinct	ADJ
cajgh-231	74	36	mechanism	mechanism	NOUN
cajgh-231	74	37	.	.	PUNCT
cajgh-231	75	1	there	there	PRON
cajgh-231	75	2	are	be	VERB
cajgh-231	75	3	two	two	NUM
cajgh-231	75	4	direct	direct	ADJ
cajgh-231	75	5	pieces	piece	NOUN
cajgh-231	75	6	of	of	ADP
cajgh-231	75	7	evidence	evidence	NOUN
cajgh-231	75	8	supporting	support	VERB
cajgh-231	75	9	a	a	DET
cajgh-231	75	10	propagation	propagation	NOUN
cajgh-231	75	11	dynamic	dynamic	ADJ
cajgh-231	75	12	in	in	ADP
cajgh-231	75	13	pd	pd	PROPN
cajgh-231	75	14	.	.	PUNCT
cajgh-231	76	1	first	first	ADV
cajgh-231	76	2	,	,	PUNCT
cajgh-231	76	3	analyses	analysis	NOUN
cajgh-231	76	4	of	of	ADP
cajgh-231	76	5	post	post	ADJ
cajgh-231	76	6	-	-	ADJ
cajgh-231	76	7	mortem	mortem	ADJ
cajgh-231	76	8	neuronal	neuronal	ADJ
cajgh-231	76	9	tissue	tissue	NOUN
cajgh-231	76	10	from	from	ADP
cajgh-231	76	11	patients	patient	NOUN
cajgh-231	76	12	who	who	PRON
cajgh-231	76	13	died	die	VERB
cajgh-231	76	14	at	at	ADP
cajgh-231	76	15	different	different	ADJ
cajgh-231	76	16	stages	stage	NOUN
cajgh-231	76	17	of	of	ADP
cajgh-231	76	18	the	the	DET
cajgh-231	76	19	disease	disease	NOUN
cajgh-231	76	20	appear	appear	VERB
cajgh-231	76	21	to	to	PART
cajgh-231	76	22	support	support	VERB
cajgh-231	76	23	a	a	DET
cajgh-231	76	24	chronological	chronological	ADJ
cajgh-231	76	25	,	,	PUNCT
cajgh-231	76	26	physical	physical	ADJ
cajgh-231	76	27	spread	spread	NOUN
cajgh-231	76	28	of	of	ADP
cajgh-231	76	29	lewy	lewy	NOUN
cajgh-231	76	30	-	-	PUNCT
cajgh-231	76	31	bodies	body	NOUN
cajgh-231	76	32	across	across	ADP
cajgh-231	76	33	the	the	DET
cajgh-231	76	34	nervous	nervous	ADJ
cajgh-231	76	35	system.36	system.36	NOUN
cajgh-231	76	36	second	second	NOUN
cajgh-231	76	37	,	,	PUNCT
cajgh-231	76	38	there	there	PRON
cajgh-231	76	39	is	be	VERB
cajgh-231	76	40	published	publish	VERB
cajgh-231	76	41	evidence	evidence	NOUN
cajgh-231	76	42	on	on	ADP
cajgh-231	76	43	the	the	DET
cajgh-231	76	44	surgical	surgical	ADJ
cajgh-231	76	45	transplantations	transplantation	NOUN
cajgh-231	76	46	of	of	ADP
cajgh-231	76	47	fetal	fetal	ADJ
cajgh-231	76	48	ventral	ventral	ADJ
cajgh-231	76	49	mesencephalic	mesencephalic	ADJ
cajgh-231	76	50	dopaminergic	dopaminergic	ADJ
cajgh-231	76	51	neurons	neuron	NOUN
cajgh-231	76	52	as	as	ADP
cajgh-231	76	53	a	a	DET
cajgh-231	76	54	treatment	treatment	NOUN
cajgh-231	76	55	of	of	ADP
cajgh-231	76	56	pd	pd	PROPN
cajgh-231	76	57	.	.	PUNCT
cajgh-231	77	1	a	a	DET
cajgh-231	77	2	number	number	NOUN
cajgh-231	77	3	of	of	ADP
cajgh-231	77	4	post	post	ADJ
cajgh-231	77	5	-	-	ADJ
cajgh-231	77	6	mortem	mortem	ADJ
cajgh-231	77	7	analyses	analysis	NOUN
cajgh-231	77	8	,	,	PUNCT
cajgh-231	77	9	performed	perform	VERB
cajgh-231	77	10	over	over	ADP
cajgh-231	77	11	10	10	NUM
cajgh-231	77	12	years	year	NOUN
cajgh-231	77	13	after	after	ADP
cajgh-231	77	14	the	the	DET
cajgh-231	77	15	transplant	transplant	NOUN
cajgh-231	77	16	,	,	PUNCT
cajgh-231	77	17	detected	detect	VERB
cajgh-231	77	18	lewy	lewy	ADJ
cajgh-231	77	19	-	-	PUNCT
cajgh-231	77	20	bodies	body	NOUN
cajgh-231	77	21	and	and	CCONJ
cajgh-231	77	22	lewy	lewy	PROPN
cajgh-231	77	23	neurites	neurite	NOUN
cajgh-231	77	24	in	in	ADP
cajgh-231	77	25	grafted	graft	VERB
cajgh-231	77	26	neurons	neuron	NOUN
cajgh-231	77	27	,	,	PUNCT
cajgh-231	77	28	in	in	ADP
cajgh-231	77	29	spite	spite	NOUN
cajgh-231	77	30	of	of	ADP
cajgh-231	77	31	the	the	DET
cajgh-231	77	32	still	still	ADV
cajgh-231	77	33	young	young	ADJ
cajgh-231	77	34	age	age	NOUN
cajgh-231	77	35	of	of	ADP
cajgh-231	77	36	the	the	DET
cajgh-231	77	37	transplanted	transplanted	ADJ
cajgh-231	77	38	tissue.37,38	tissue.37,38	NOUN
cajgh-231	77	39	this	this	DET
cajgh-231	77	40	latter	latter	ADJ
cajgh-231	77	41	fact	fact	NOUN
cajgh-231	77	42	is	be	AUX
cajgh-231	77	43	in	in	ADP
cajgh-231	77	44	addition	addition	NOUN
cajgh-231	77	45	evidence	evidence	NOUN
cajgh-231	77	46	of	of	ADP
cajgh-231	77	47	the	the	DET
cajgh-231	77	48	non	non	NOUN
cajgh-231	77	49	-	-	NOUN
cajgh-231	77	50	essentiality	essentiality	NOUN
cajgh-231	77	51	of	of	ADP
cajgh-231	77	52	cellular	cellular	ADJ
cajgh-231	77	53	ageing	ageing	NOUN
cajgh-231	77	54	to	to	ADP
cajgh-231	77	55	the	the	DET
cajgh-231	77	56	acquisition	acquisition	NOUN
cajgh-231	77	57	of	of	ADP
cajgh-231	77	58	the	the	DET
cajgh-231	77	59	pd	pd	NOUN
cajgh-231	77	60	-	-	NOUN
cajgh-231	77	61	state	state	NOUN
cajgh-231	77	62	.	.	PUNCT
cajgh-231	78	1	in	in	ADP
cajgh-231	78	2	this	this	DET
cajgh-231	78	3	section	section	NOUN
cajgh-231	78	4	,	,	PUNCT
cajgh-231	78	5	we	we	PRON
cajgh-231	78	6	argued	argue	VERB
cajgh-231	78	7	that	that	SCONJ
cajgh-231	78	8	ageingassociated	ageingassociated	ADJ
cajgh-231	78	9	damage	damage	NOUN
cajgh-231	78	10	caused	cause	VERB
cajgh-231	78	11	by	by	ADP
cajgh-231	78	12	oxidative	oxidative	ADJ
cajgh-231	78	13	stress	stress	NOUN
cajgh-231	78	14	in	in	ADP
cajgh-231	78	15	mitochondria	mitochondria	NOUN
cajgh-231	78	16	could	could	AUX
cajgh-231	78	17	be	be	AUX
cajgh-231	78	18	the	the	DET
cajgh-231	78	19	trigger	trigger	NOUN
cajgh-231	78	20	for	for	ADP
cajgh-231	78	21	a	a	DET
cajgh-231	78	22	primordial	primordial	ADJ
cajgh-231	78	23	individual	individual	ADJ
cajgh-231	78	24	cell	cell	NOUN
cajgh-231	78	25	to	to	PART
cajgh-231	78	26	shift	shift	VERB
cajgh-231	78	27	its	its	PRON
cajgh-231	78	28	gene	gene	NOUN
cajgh-231	78	29	expression	expression	NOUN
cajgh-231	78	30	program	program	NOUN
cajgh-231	78	31	to	to	ADP
cajgh-231	78	32	the	the	DET
cajgh-231	78	33	pd	pd	NOUN
cajgh-231	78	34	-	-	NOUN
cajgh-231	78	35	state	state	NOUN
cajgh-231	78	36	.	.	PUNCT
cajgh-231	79	1	the	the	DET
cajgh-231	79	2	shift	shift	NOUN
cajgh-231	79	3	to	to	ADP
cajgh-231	79	4	the	the	DET
cajgh-231	79	5	pd	pd	NOUN
cajgh-231	79	6	-	-	NOUN
cajgh-231	79	7	state	state	NOUN
cajgh-231	79	8	would	would	AUX
cajgh-231	79	9	be	be	AUX
cajgh-231	79	10	a	a	DET
cajgh-231	79	11	probabilistic	probabilistic	ADJ
cajgh-231	79	12	event	event	NOUN
cajgh-231	79	13	,	,	PUNCT
cajgh-231	79	14	its	its	PRON
cajgh-231	79	15	likelihood	likelihood	NOUN
cajgh-231	79	16	increasing	increase	VERB
cajgh-231	79	17	nonlinearly	nonlinearly	ADV
cajgh-231	79	18	with	with	ADP
cajgh-231	79	19	that	that	DET
cajgh-231	79	20	accumulated	accumulate	VERB
cajgh-231	79	21	damage	damage	NOUN
cajgh-231	79	22	in	in	ADP
cajgh-231	79	23	the	the	DET
cajgh-231	79	24	cell	cell	NOUN
cajgh-231	79	25	.	.	PUNCT
cajgh-231	80	1	on	on	ADP
cajgh-231	80	2	the	the	DET
cajgh-231	80	3	other	other	ADJ
cajgh-231	80	4	hand	hand	NOUN
cajgh-231	80	5	,	,	PUNCT
cajgh-231	80	6	the	the	DET
cajgh-231	80	7	subsequent	subsequent	ADJ
cajgh-231	80	8	appearance	appearance	NOUN
cajgh-231	80	9	of	of	ADP
cajgh-231	80	10	the	the	DET
cajgh-231	80	11	pd	pd	NOUN
cajgh-231	80	12	-	-	NOUN
cajgh-231	80	13	state	state	NOUN
cajgh-231	80	14	in	in	ADP
cajgh-231	80	15	numerous	numerous	ADJ
cajgh-231	80	16	other	other	ADJ
cajgh-231	80	17	cells	cell	NOUN
cajgh-231	80	18	could	could	AUX
cajgh-231	80	19	no	no	ADV
cajgh-231	80	20	longer	long	ADV
cajgh-231	80	21	be	be	AUX
cajgh-231	80	22	explained	explain	VERB
cajgh-231	80	23	by	by	ADP
cajgh-231	80	24	cell	cell	NOUN
cajgh-231	80	25	ageing	ageing	NOUN
cajgh-231	80	26	.	.	PUNCT
cajgh-231	81	1	rather	rather	ADV
cajgh-231	81	2	,	,	PUNCT
cajgh-231	81	3	it	it	PRON
cajgh-231	81	4	likely	likely	ADV
cajgh-231	81	5	involves	involve	VERB
cajgh-231	81	6	a	a	DET
cajgh-231	81	7	separate	separate	ADJ
cajgh-231	81	8	mechanism	mechanism	NOUN
cajgh-231	81	9	of	of	ADP
cajgh-231	81	10	propagation	propagation	NOUN
cajgh-231	81	11	of	of	ADP
cajgh-231	81	12	the	the	DET
cajgh-231	81	13	pd	pd	NOUN
cajgh-231	81	14	-	-	NOUN
cajgh-231	81	15	state	state	NOUN
cajgh-231	81	16	.	.	PUNCT
cajgh-231	82	1	the	the	DET
cajgh-231	82	2	propagation	propagation	NOUN
cajgh-231	82	3	of	of	ADP
cajgh-231	82	4	the	the	DET
cajgh-231	82	5	pd	pd	NOUN
cajgh-231	82	6	-	-	NOUN
cajgh-231	82	7	state	state	NOUN
cajgh-231	82	8	the	the	DET
cajgh-231	82	9	spread	spread	NOUN
cajgh-231	82	10	of	of	ADP
cajgh-231	82	11	the	the	DET
cajgh-231	82	12	pd	pd	NOUN
cajgh-231	82	13	-	-	PUNCT
cajgh-231	82	14	state	state	NOUN
cajgh-231	82	15	is	be	AUX
cajgh-231	82	16	a	a	DET
cajgh-231	82	17	slow	slow	ADJ
cajgh-231	82	18	process	process	NOUN
cajgh-231	82	19	,	,	PUNCT
cajgh-231	82	20	as	as	SCONJ
cajgh-231	82	21	evidenced	evidence	VERB
cajgh-231	82	22	by	by	ADP
cajgh-231	82	23	the	the	DET
cajgh-231	82	24	approximate	approximate	ADJ
cajgh-231	82	25	decade	decade	NOUN
cajgh-231	82	26	that	that	SCONJ
cajgh-231	82	27	it	it	PRON
cajgh-231	82	28	takes	take	VERB
cajgh-231	82	29	an	an	DET
cajgh-231	82	30	implanted	implant	VERB
cajgh-231	82	31	fetal	fetal	ADJ
cajgh-231	82	32	neuron	neuron	NOUN
cajgh-231	82	33	in	in	ADP
cajgh-231	82	34	the	the	DET
cajgh-231	82	35	brain	brain	NOUN
cajgh-231	82	36	of	of	ADP
cajgh-231	82	37	a	a	DET
cajgh-231	82	38	pd	pd	NOUN
cajgh-231	82	39	patient	patient	NOUN
cajgh-231	82	40	to	to	PART
cajgh-231	82	41	develop	develop	VERB
cajgh-231	82	42	lewy	lewy	PROPN
cajgh-231	82	43	bodies.37,38	bodies.37,38	VERB
cajgh-231	82	44	the	the	DET
cajgh-231	82	45	mechanism	mechanism	NOUN
cajgh-231	82	46	of	of	ADP
cajgh-231	82	47	propagation	propagation	NOUN
cajgh-231	82	48	of	of	ADP
cajgh-231	82	49	the	the	DET
cajgh-231	82	50	pd	pd	ADJ
cajgh-231	82	51	-	-	PUNCT
cajgh-231	82	52	state	state	NOUN
cajgh-231	82	53	remains	remain	VERB
cajgh-231	82	54	undetermined	undetermined	ADJ
cajgh-231	82	55	.	.	PUNCT
cajgh-231	83	1	however	however	ADV
cajgh-231	83	2	,	,	PUNCT
cajgh-231	83	3	new	new	ADJ
cajgh-231	83	4	modes	mode	NOUN
cajgh-231	83	5	of	of	ADP
cajgh-231	83	6	inter	inter	ADJ
cajgh-231	83	7	-	-	ADJ
cajgh-231	83	8	cellular	cellular	ADJ
cajgh-231	83	9	communication	communication	NOUN
cajgh-231	83	10	continue	continue	VERB
cajgh-231	83	11	to	to	PART
cajgh-231	83	12	be	be	AUX
cajgh-231	83	13	discovered.39	discovered.39	NOUN
cajgh-231	83	14	in	in	ADP
cajgh-231	83	15	this	this	DET
cajgh-231	83	16	section	section	NOUN
cajgh-231	83	17	,	,	PUNCT
cajgh-231	83	18	we	we	PRON
cajgh-231	83	19	discuss	discuss	VERB
cajgh-231	83	20	how	how	SCONJ
cajgh-231	83	21	propagation	propagation	NOUN
cajgh-231	83	22	of	of	ADP
cajgh-231	83	23	the	the	DET
cajgh-231	83	24	pd	pd	PROPN
cajgh-231	83	25	-	-	PUNCT
cajgh-231	83	26	state	state	NOUN
cajgh-231	83	27	may	may	AUX
cajgh-231	83	28	occur	occur	VERB
cajgh-231	83	29	.	.	PUNCT
cajgh-231	84	1	one	one	NUM
cajgh-231	84	2	hypothesis	hypothesis	NOUN
cajgh-231	84	3	posits	posit	NOUN
cajgh-231	84	4	that	that	SCONJ
cajgh-231	84	5	alpha	alpha	NOUN
cajgh-231	84	6	-	-	PUNCT
cajgh-231	84	7	synuclein	synuclein	NOUN
cajgh-231	84	8	can	can	AUX
cajgh-231	84	9	behave	behave	VERB
cajgh-231	84	10	as	as	ADP
cajgh-231	84	11	a	a	DET
cajgh-231	84	12	prion	prion	NOUN
cajgh-231	84	13	and	and	CCONJ
cajgh-231	84	14	that	that	SCONJ
cajgh-231	84	15	pd	pd	PROPN
cajgh-231	84	16	is	be	AUX
cajgh-231	84	17	a	a	DET
cajgh-231	84	18	prion	prion	NOUN
cajgh-231	84	19	disorder.9,13	disorder.9,13	VERB
cajgh-231	84	20	under	under	ADP
cajgh-231	84	21	this	this	DET
cajgh-231	84	22	theory	theory	NOUN
cajgh-231	84	23	,	,	PUNCT
cajgh-231	84	24	there	there	PRON
cajgh-231	84	25	exists	exist	VERB
cajgh-231	84	26	a	a	DET
cajgh-231	84	27	misfolded	misfolded	ADJ
cajgh-231	84	28	form	form	NOUN
cajgh-231	84	29	of	of	ADP
cajgh-231	84	30	alpha	alpha	NOUN
cajgh-231	84	31	-	-	PUNCT
cajgh-231	84	32	synuclein	synuclein	NOUN
cajgh-231	84	33	that	that	PRON
cajgh-231	84	34	is	be	AUX
cajgh-231	84	35	self	self	NOUN
cajgh-231	84	36	-	-	PUNCT
cajgh-231	84	37	propagating	propagating	NOUN
cajgh-231	84	38	,	,	PUNCT
cajgh-231	84	39	having	have	VERB
cajgh-231	84	40	the	the	DET
cajgh-231	84	41	ability	ability	NOUN
cajgh-231	84	42	to	to	PART
cajgh-231	84	43	induce	induce	VERB
cajgh-231	84	44	similar	similar	ADJ
cajgh-231	84	45	misfolding	misfolding	NOUN
cajgh-231	84	46	in	in	ADP
cajgh-231	84	47	well	well	ADV
cajgh-231	84	48	-	-	PUNCT
cajgh-231	84	49	conformed	conform	VERB
cajgh-231	84	50	alpha	alpha	NOUN
cajgh-231	84	51	-	-	PUNCT
cajgh-231	84	52	synuclein	synuclein	NOUN
cajgh-231	84	53	.	.	PUNCT
cajgh-231	85	1	the	the	DET
cajgh-231	85	2	transfer	transfer	NOUN
cajgh-231	85	3	of	of	ADP
cajgh-231	85	4	the	the	DET
cajgh-231	85	5	misfolded	misfolded	ADJ
cajgh-231	85	6	form	form	NOUN
cajgh-231	85	7	of	of	ADP
cajgh-231	85	8	alpha	alpha	NOUN
cajgh-231	85	9	-	-	PUNCT
cajgh-231	85	10	synuclein	synuclein	NOUN
cajgh-231	85	11	from	from	ADP
cajgh-231	85	12	cell	cell	NOUN
cajgh-231	85	13	to	to	ADP
cajgh-231	85	14	cell	cell	NOUN
cajgh-231	85	15	would	would	AUX
cajgh-231	85	16	thus	thus	ADV
cajgh-231	85	17	result	result	VERB
cajgh-231	85	18	in	in	ADP
cajgh-231	85	19	the	the	DET
cajgh-231	85	20	inter	inter	ADJ
cajgh-231	85	21	-	-	ADJ
cajgh-231	85	22	cellular	cellular	ADJ
cajgh-231	85	23	spread	spread	NOUN
cajgh-231	85	24	of	of	ADP
cajgh-231	85	25	pd	pd	PROPN
cajgh-231	85	26	.	.	PUNCT
cajgh-231	86	1	however	however	ADV
cajgh-231	86	2	,	,	PUNCT
cajgh-231	86	3	a	a	DET
cajgh-231	86	4	western	western	ADJ
cajgh-231	86	5	blot	blot	NOUN
cajgh-231	86	6	analysis	analysis	NOUN
cajgh-231	86	7	did	do	AUX
cajgh-231	86	8	not	not	PART
cajgh-231	86	9	detect	detect	VERB
cajgh-231	86	10	any	any	DET
cajgh-231	86	11	alpha	alpha	NOUN
cajgh-231	86	12	-	-	PUNCT
cajgh-231	86	13	synuclein	synuclein	NOUN
cajgh-231	86	14	in	in	ADP
cajgh-231	86	15	the	the	DET
cajgh-231	86	16	fibroblasts	fibroblast	NOUN
cajgh-231	86	17	utilized	utilize	VERB
cajgh-231	86	18	in	in	ADP
cajgh-231	86	19	the	the	DET
cajgh-231	86	20	pd	pd	PROPN
cajgh-231	86	21	ipsc	ipsc	PROPN
cajgh-231	86	22	experiments	experiment	NOUN
cajgh-231	86	23	discussed	discuss	VERB
cajgh-231	86	24	earlier.20	earlier.20	PROPN
cajgh-231	86	25	therefore	therefore	ADV
cajgh-231	86	26	,	,	PUNCT
cajgh-231	86	27	a	a	DET
cajgh-231	86	28	pd	pd	NOUN
cajgh-231	86	29	phenotype	phenotype	NOUN
cajgh-231	86	30	in	in	ADP
cajgh-231	86	31	fibroblast	fibroblast	ADJ
cajgh-231	86	32	-	-	PUNCT
cajgh-231	86	33	derived	derive	VERB
cajgh-231	86	34	neurons	neuron	NOUN
cajgh-231	86	35	can	can	AUX
cajgh-231	86	36	not	not	PART
cajgh-231	86	37	be	be	AUX
cajgh-231	86	38	explained	explain	VERB
cajgh-231	86	39	by	by	ADP
cajgh-231	86	40	the	the	DET
cajgh-231	86	41	lingering	linger	VERB
cajgh-231	86	42	presence	presence	NOUN
cajgh-231	86	43	of	of	ADP
cajgh-231	86	44	a	a	DET
cajgh-231	86	45	hypothetical	hypothetical	ADJ
cajgh-231	86	46	infectious	infectious	ADJ
cajgh-231	86	47	form	form	NOUN
cajgh-231	86	48	of	of	ADP
cajgh-231	86	49	alpha	alpha	NOUN
cajgh-231	86	50	-	-	PUNCT
cajgh-231	86	51	synuclein	synuclein	NOUN
cajgh-231	86	52	.	.	PUNCT
cajgh-231	87	1	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	87	2	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	87	3	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	87	4	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	87	5	valente	valente	NOUN
cajgh-231	87	6	this	this	DET
cajgh-231	87	7	work	work	NOUN
cajgh-231	87	8	is	be	AUX
cajgh-231	87	9	licensed	license	VERB
cajgh-231	87	10	under	under	ADP
cajgh-231	87	11	a	a	DET
cajgh-231	87	12	creative	creative	ADJ
cajgh-231	87	13	commons	common	NOUN
cajgh-231	87	14	attribution	attribution	NOUN
cajgh-231	87	15	4.0	4.0	NUM
cajgh-231	87	16	united	unite	VERB
cajgh-231	87	17	states	states	PROPN
cajgh-231	87	18	license	license	NOUN
cajgh-231	87	19	.	.	PUNCT
cajgh-231	88	1	this	this	DET
cajgh-231	88	2	journal	journal	NOUN
cajgh-231	88	3	is	be	AUX
cajgh-231	88	4	published	publish	VERB
cajgh-231	88	5	by	by	ADP
cajgh-231	88	6	theuniversity	theuniversity	NOUN
cajgh-231	88	7	library	library	NOUN
cajgh-231	88	8	system	system	NOUN
cajgh-231	88	9	of	of	ADP
cajgh-231	88	10	the	the	DET
cajgh-231	88	11	university	university	PROPN
cajgh-231	88	12	of	of	ADP
cajgh-231	88	13	pittsburgh	pittsburgh	PROPN
cajgh-231	88	14	as	as	ADP
cajgh-231	88	15	part	part	NOUN
cajgh-231	88	16	of	of	ADP
cajgh-231	88	17	its	its	PRON
cajgh-231	88	18	d	d	NOUN
cajgh-231	88	19	-	-	PUNCT
cajgh-231	88	20	scribe	scribe	VERB
cajgh-231	88	21	digital	digital	ADJ
cajgh-231	88	22	publishing	publishing	NOUN
cajgh-231	88	23	program	program	NOUN
cajgh-231	88	24	and	and	CCONJ
cajgh-231	88	25	is	be	AUX
cajgh-231	88	26	cosponsored	cosponsor	VERB
cajgh-231	88	27	by	by	ADP
cajgh-231	88	28	the	the	DET
cajgh-231	88	29	university	university	PROPN
cajgh-231	88	30	of	of	ADP
cajgh-231	88	31	pittsburgh	pittsburgh	PROPN
cajgh-231	88	32	press	press	NOUN
cajgh-231	88	33	.	.	PUNCT
cajgh-231	89	1	central	central	ADJ
cajgh-231	89	2	asian	asian	ADJ
cajgh-231	89	3	journal	journal	NOUN
cajgh-231	89	4	of	of	ADP
cajgh-231	89	5	global	global	ADJ
cajgh-231	89	6	health	health	NOUN
cajgh-231	89	7	volume	volume	NOUN
cajgh-231	89	8	4	4	NUM
cajgh-231	89	9	,	,	PUNCT
cajgh-231	89	10	no	no	INTJ
cajgh-231	89	11	.	.	NOUN
cajgh-231	89	12	1	1	NUM
cajgh-231	89	13	(	(	PUNCT
cajgh-231	89	14	2015	2015	NUM
cajgh-231	89	15	)	)	PUNCT
cajgh-231	89	16	|	|	ADV
cajgh-231	89	17	issn	issn	VERB
cajgh-231	89	18	2166	2166	NUM
cajgh-231	89	19	-	-	SYM
cajgh-231	89	20	7403	7403	NUM
cajgh-231	89	21	(	(	PUNCT
cajgh-231	89	22	online	online	ADJ
cajgh-231	89	23	)	)	PUNCT
cajgh-231	89	24	|	|	ADV
cajgh-231	89	25	doi	doi	X
cajgh-231	89	26	10.5195	10.5195	NUM
cajgh-231	89	27	/	/	SYM
cajgh-231	89	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	89	29	nevertheless	nevertheless	ADV
cajgh-231	90	1	,	,	PUNCT
cajgh-231	90	2	there	there	PRON
cajgh-231	90	3	is	be	VERB
cajgh-231	90	4	the	the	DET
cajgh-231	90	5	possibility	possibility	NOUN
cajgh-231	90	6	that	that	SCONJ
cajgh-231	90	7	a	a	DET
cajgh-231	90	8	different	different	ADJ
cajgh-231	90	9	biological	biological	ADJ
cajgh-231	90	10	entity	entity	NOUN
cajgh-231	90	11	is	be	AUX
cajgh-231	90	12	responsible	responsible	ADJ
cajgh-231	90	13	for	for	ADP
cajgh-231	90	14	propagating	propagate	VERB
cajgh-231	90	15	the	the	DET
cajgh-231	90	16	pd	pd	NOUN
cajgh-231	90	17	-	-	NOUN
cajgh-231	90	18	state	state	NOUN
cajgh-231	90	19	.	.	PUNCT
cajgh-231	91	1	recently	recently	ADV
cajgh-231	91	2	,	,	PUNCT
cajgh-231	91	3	the	the	DET
cajgh-231	91	4	inter	inter	ADJ
cajgh-231	91	5	-	-	ADJ
cajgh-231	91	6	cellular	cellular	ADJ
cajgh-231	91	7	exchange	exchange	NOUN
cajgh-231	91	8	of	of	ADP
cajgh-231	91	9	mitochondrial	mitochondrial	ADJ
cajgh-231	91	10	dna	dna	NOUN
cajgh-231	91	11	(	(	PUNCT
cajgh-231	91	12	mtdna	mtdna	ADV
cajgh-231	91	13	)	)	PUNCT
cajgh-231	91	14	has	have	AUX
cajgh-231	91	15	been	be	AUX
cajgh-231	91	16	demonstrated.40,41	demonstrated.40,41	NOUN
cajgh-231	91	17	we	we	PRON
cajgh-231	91	18	propose	propose	VERB
cajgh-231	91	19	that	that	SCONJ
cajgh-231	91	20	mtdna	mtdna	NOUN
cajgh-231	91	21	could	could	AUX
cajgh-231	91	22	be	be	AUX
cajgh-231	91	23	the	the	DET
cajgh-231	91	24	vehicle	vehicle	NOUN
cajgh-231	91	25	for	for	ADP
cajgh-231	91	26	the	the	DET
cajgh-231	91	27	inter	inter	ADJ
cajgh-231	91	28	-	-	ADJ
cajgh-231	91	29	cellular	cellular	ADJ
cajgh-231	91	30	transmission	transmission	NOUN
cajgh-231	91	31	of	of	ADP
cajgh-231	91	32	the	the	DET
cajgh-231	91	33	pdstate	pdstate	NOUN
cajgh-231	91	34	.	.	PUNCT
cajgh-231	92	1	comprehensive	comprehensive	ADJ
cajgh-231	92	2	research	research	NOUN
cajgh-231	92	3	with	with	ADP
cajgh-231	92	4	neuron	neuron	NOUN
cajgh-231	92	5	-	-	PUNCT
cajgh-231	92	6	platelet	platelet	NOUN
cajgh-231	92	7	cytoplasmic	cytoplasmic	ADJ
cajgh-231	92	8	hybrids	hybrid	NOUN
cajgh-231	92	9	supports	support	VERB
cajgh-231	92	10	that	that	SCONJ
cajgh-231	92	11	anomalous	anomalous	ADJ
cajgh-231	92	12	mtdna	mtdna	NOUN
cajgh-231	92	13	may	may	AUX
cajgh-231	92	14	suffice	suffice	VERB
cajgh-231	92	15	to	to	PART
cajgh-231	92	16	set	set	VERB
cajgh-231	92	17	off	off	ADP
cajgh-231	92	18	the	the	DET
cajgh-231	92	19	pd	pd	NOUN
cajgh-231	92	20	-	-	NOUN
cajgh-231	92	21	state	state	NOUN
cajgh-231	92	22	in	in	ADP
cajgh-231	92	23	a	a	DET
cajgh-231	92	24	cell	cell	NOUN
cajgh-231	92	25	.	.	PUNCT
cajgh-231	93	1	a	a	DET
cajgh-231	93	2	pd	pd	PROPN
cajgh-231	93	3	cybrid	cybrid	PROPN
cajgh-231	93	4	cell	cell	NOUN
cajgh-231	93	5	is	be	AUX
cajgh-231	93	6	created	create	VERB
cajgh-231	93	7	in	in	ADP
cajgh-231	93	8	vitro	vitro	X
cajgh-231	93	9	by	by	ADP
cajgh-231	93	10	the	the	DET
cajgh-231	93	11	fusion	fusion	NOUN
cajgh-231	93	12	of	of	ADP
cajgh-231	93	13	a	a	DET
cajgh-231	93	14	neuronal	neuronal	ADJ
cajgh-231	93	15	cell	cell	NOUN
cajgh-231	93	16	depleted	deplete	VERB
cajgh-231	93	17	of	of	ADP
cajgh-231	93	18	endogenous	endogenous	ADJ
cajgh-231	93	19	mtdna	mtdna	NOUN
cajgh-231	93	20	with	with	ADP
cajgh-231	93	21	an	an	DET
cajgh-231	93	22	enucleated	enucleated	ADJ
cajgh-231	93	23	platelet	platelet	NOUN
cajgh-231	93	24	from	from	ADP
cajgh-231	93	25	a	a	DET
cajgh-231	93	26	pd	pd	NOUN
cajgh-231	93	27	donor	donor	NOUN
cajgh-231	93	28	.	.	PUNCT
cajgh-231	94	1	thus	thus	ADV
cajgh-231	94	2	,	,	PUNCT
cajgh-231	94	3	the	the	DET
cajgh-231	94	4	mtdna	mtdna	NOUN
cajgh-231	94	5	of	of	ADP
cajgh-231	94	6	the	the	DET
cajgh-231	94	7	cybrid	cybrid	ADJ
cajgh-231	94	8	cell	cell	NOUN
cajgh-231	94	9	is	be	AUX
cajgh-231	94	10	that	that	PRON
cajgh-231	94	11	of	of	ADP
cajgh-231	94	12	the	the	DET
cajgh-231	94	13	platelet	platelet	NOUN
cajgh-231	94	14	from	from	ADP
cajgh-231	94	15	the	the	DET
cajgh-231	94	16	pd	pd	PROPN
cajgh-231	94	17	patient	patient	NOUN
cajgh-231	94	18	,	,	PUNCT
cajgh-231	94	19	while	while	SCONJ
cajgh-231	94	20	its	its	PRON
cajgh-231	94	21	nuclear	nuclear	ADJ
cajgh-231	94	22	dna	dna	NOUN
cajgh-231	94	23	is	be	AUX
cajgh-231	94	24	that	that	PRON
cajgh-231	94	25	of	of	ADP
cajgh-231	94	26	the	the	DET
cajgh-231	94	27	disease	disease	NOUN
cajgh-231	94	28	-	-	PUNCT
cajgh-231	94	29	free	free	ADJ
cajgh-231	94	30	neuronal	neuronal	ADJ
cajgh-231	94	31	cell	cell	NOUN
cajgh-231	94	32	.	.	PUNCT
cajgh-231	95	1	various	various	ADJ
cajgh-231	95	2	pd	pd	PROPN
cajgh-231	95	3	characteristic	characteristic	PROPN
cajgh-231	95	4	alterations	alteration	NOUN
cajgh-231	95	5	have	have	AUX
cajgh-231	95	6	been	be	AUX
cajgh-231	95	7	observed	observe	VERB
cajgh-231	95	8	in	in	ADP
cajgh-231	95	9	pd	pd	PROPN
cajgh-231	95	10	cybrids	cybrids	PROPN
cajgh-231	95	11	,	,	PUNCT
cajgh-231	95	12	most	most	ADV
cajgh-231	95	13	prominently	prominently	ADV
cajgh-231	95	14	,	,	PUNCT
cajgh-231	95	15	inclusions	inclusion	NOUN
cajgh-231	95	16	that	that	PRON
cajgh-231	95	17	replicate	replicate	VERB
cajgh-231	95	18	the	the	DET
cajgh-231	95	19	essential	essential	ADJ
cajgh-231	95	20	biochemical	biochemical	ADJ
cajgh-231	95	21	and	and	CCONJ
cajgh-231	95	22	structural	structural	ADJ
cajgh-231	95	23	features	feature	NOUN
cajgh-231	95	24	found	find	VERB
cajgh-231	95	25	in	in	ADP
cajgh-231	95	26	lewy	lewy	NOUN
cajgh-231	95	27	-	-	PUNCT
cajgh-231	95	28	bodies	body	NOUN
cajgh-231	95	29	in	in	ADP
cajgh-231	95	30	the	the	DET
cajgh-231	95	31	brain	brain	NOUN
cajgh-231	95	32	of	of	ADP
cajgh-231	95	33	pd	pd	PROPN
cajgh-231	95	34	patients.15,42,43	patients.15,42,43	PROPN
cajgh-231	95	35	the	the	DET
cajgh-231	95	36	sufficiency	sufficiency	NOUN
cajgh-231	95	37	of	of	ADP
cajgh-231	95	38	mtdna	mtdna	NOUN
cajgh-231	95	39	to	to	PART
cajgh-231	95	40	trigger	trigger	VERB
cajgh-231	95	41	the	the	DET
cajgh-231	95	42	pdstate	pdstate	NOUN
cajgh-231	95	43	in	in	ADP
cajgh-231	95	44	a	a	DET
cajgh-231	95	45	cell	cell	NOUN
cajgh-231	95	46	is	be	AUX
cajgh-231	95	47	supported	support	VERB
cajgh-231	95	48	by	by	ADP
cajgh-231	95	49	its	its	PRON
cajgh-231	95	50	ability	ability	NOUN
cajgh-231	95	51	to	to	PART
cajgh-231	95	52	induce	induce	VERB
cajgh-231	95	53	epigenetic	epigenetic	ADJ
cajgh-231	95	54	modifications	modification	NOUN
cajgh-231	95	55	and	and	CCONJ
cajgh-231	95	56	to	to	PART
cajgh-231	95	57	modulate	modulate	VERB
cajgh-231	95	58	geneexpression	geneexpression	NOUN
cajgh-231	95	59	in	in	ADP
cajgh-231	95	60	nuclear	nuclear	ADJ
cajgh-231	95	61	dna	dna	NOUN
cajgh-231	95	62	.	.	PUNCT
cajgh-231	96	1	in	in	ADP
cajgh-231	96	2	the	the	DET
cajgh-231	96	3	context	context	NOUN
cajgh-231	96	4	of	of	ADP
cajgh-231	96	5	tumorigenesis	tumorigenesis	NOUN
cajgh-231	96	6	,	,	PUNCT
cajgh-231	96	7	work	work	NOUN
cajgh-231	96	8	by	by	ADP
cajgh-231	96	9	smiraglia	smiraglia	PROPN
cajgh-231	96	10	et	et	PROPN
cajgh-231	96	11	al.44	al.44	NOUN
cajgh-231	96	12	and	and	CCONJ
cajgh-231	96	13	by	by	ADP
cajgh-231	96	14	xie	xie	PROPN
cajgh-231	96	15	et	et	PROPN
cajgh-231	96	16	al.45	al.45	PROPN
cajgh-231	96	17	shows	show	VERB
cajgh-231	96	18	that	that	SCONJ
cajgh-231	96	19	alterations	alteration	NOUN
cajgh-231	96	20	to	to	PART
cajgh-231	96	21	mtdna	mtdna	ADV
cajgh-231	96	22	affect	affect	VERB
cajgh-231	96	23	the	the	DET
cajgh-231	96	24	methylation	methylation	NOUN
cajgh-231	96	25	pattern	pattern	NOUN
cajgh-231	96	26	of	of	ADP
cajgh-231	96	27	various	various	ADJ
cajgh-231	96	28	nuclear	nuclear	ADJ
cajgh-231	96	29	genes	gene	NOUN
cajgh-231	96	30	.	.	PUNCT
cajgh-231	97	1	bellizzi	bellizzi	NOUN
cajgh-231	97	2	et	et	PROPN
cajgh-231	97	3	al.46	al.46	PROPN
cajgh-231	97	4	report	report	VERB
cajgh-231	97	5	that	that	PRON
cajgh-231	97	6	methylation	methylation	NOUN
cajgh-231	97	7	and	and	CCONJ
cajgh-231	97	8	gene	gene	NOUN
cajgh-231	97	9	expression	expression	NOUN
cajgh-231	97	10	patterns	pattern	NOUN
cajgh-231	97	11	of	of	ADP
cajgh-231	97	12	nuclear	nuclear	ADJ
cajgh-231	97	13	genes	gene	NOUN
cajgh-231	97	14	in	in	ADP
cajgh-231	97	15	cybrids	cybrid	NOUN
cajgh-231	97	16	depend	depend	VERB
cajgh-231	97	17	on	on	ADP
cajgh-231	97	18	the	the	DET
cajgh-231	97	19	mtdna	mtdna	NOUN
cajgh-231	97	20	donor	donor	PROPN
cajgh-231	97	21	haplogroup	haplogroup	NOUN
cajgh-231	97	22	.	.	PUNCT
cajgh-231	98	1	kelly	kelly	PROPN
cajgh-231	98	2	et	et	PROPN
cajgh-231	98	3	al.47	al.47	PROPN
cajgh-231	98	4	proposed	propose	VERB
cajgh-231	98	5	that	that	SCONJ
cajgh-231	98	6	mtdna	mtdna	PROPN
cajgh-231	98	7	haplotypes	haplotype	NOUN
cajgh-231	98	8	play	play	VERB
cajgh-231	98	9	a	a	DET
cajgh-231	98	10	pivotal	pivotal	ADJ
cajgh-231	98	11	role	role	NOUN
cajgh-231	98	12	in	in	ADP
cajgh-231	98	13	the	the	DET
cajgh-231	98	14	process	process	NOUN
cajgh-231	98	15	of	of	ADP
cajgh-231	98	16	differentiation	differentiation	NOUN
cajgh-231	98	17	and	and	CCONJ
cajgh-231	98	18	mediate	mediate	VERB
cajgh-231	98	19	the	the	DET
cajgh-231	98	20	fate	fate	NOUN
cajgh-231	98	21	of	of	ADP
cajgh-231	98	22	the	the	DET
cajgh-231	98	23	cell	cell	NOUN
cajgh-231	98	24	.	.	PUNCT
cajgh-231	99	1	in	in	ADP
cajgh-231	99	2	mouse	mouse	NOUN
cajgh-231	99	3	undifferentiated	undifferentiate	VERB
cajgh-231	99	4	and	and	CCONJ
cajgh-231	99	5	differentiating	differentiating	ADJ
cajgh-231	99	6	embryonic	embryonic	ADJ
cajgh-231	99	7	stem	stem	NOUN
cajgh-231	99	8	cells	cell	NOUN
cajgh-231	99	9	,	,	PUNCT
cajgh-231	99	10	with	with	ADP
cajgh-231	99	11	the	the	DET
cajgh-231	99	12	same	same	ADJ
cajgh-231	99	13	nuclear	nuclear	ADJ
cajgh-231	99	14	dna	dna	NOUN
cajgh-231	99	15	haplotype	haplotype	NOUN
cajgh-231	99	16	but	but	CCONJ
cajgh-231	99	17	distinct	distinct	ADJ
cajgh-231	99	18	mtdna	mtdna	NOUN
cajgh-231	99	19	haplotypes	haplotype	NOUN
cajgh-231	99	20	,	,	PUNCT
cajgh-231	99	21	they	they	PRON
cajgh-231	99	22	observed	observe	VERB
cajgh-231	99	23	mtdna	mtdna	ADV
cajgh-231	99	24	haplotypespecific	haplotypespecific	ADJ
cajgh-231	99	25	expression	expression	NOUN
cajgh-231	99	26	of	of	ADP
cajgh-231	99	27	genes	gene	NOUN
cajgh-231	99	28	involved	involve	VERB
cajgh-231	99	29	in	in	ADP
cajgh-231	99	30	pluripotency	pluripotency	NOUN
cajgh-231	99	31	,	,	PUNCT
cajgh-231	99	32	differentiation	differentiation	NOUN
cajgh-231	99	33	,	,	PUNCT
cajgh-231	99	34	mitochondrial	mitochondrial	ADJ
cajgh-231	99	35	energy	energy	NOUN
cajgh-231	99	36	metabolism	metabolism	NOUN
cajgh-231	99	37	,	,	PUNCT
cajgh-231	99	38	and	and	CCONJ
cajgh-231	99	39	dna	dna	PROPN
cajgh-231	99	40	methylation	methylation	NOUN
cajgh-231	99	41	.	.	PUNCT
cajgh-231	100	1	no	no	DET
cajgh-231	100	2	specific	specific	ADJ
cajgh-231	100	3	mutations	mutation	NOUN
cajgh-231	100	4	in	in	ADP
cajgh-231	100	5	mtdna	mtdna	ADV
cajgh-231	100	6	have	have	AUX
cajgh-231	100	7	been	be	AUX
cajgh-231	100	8	consistently	consistently	ADV
cajgh-231	100	9	associated	associate	VERB
cajgh-231	100	10	with	with	ADP
cajgh-231	100	11	pd.48	pd.48	ADJ
cajgh-231	100	12	however	however	ADV
cajgh-231	100	13	,	,	PUNCT
cajgh-231	100	14	heteroplasmy	heteroplasmy	PROPN
cajgh-231	100	15	of	of	ADP
cajgh-231	100	16	mtdna	mtdna	X
cajgh-231	100	17	(	(	PUNCT
cajgh-231	100	18	i.e.	i.e.	X
cajgh-231	100	19	,	,	PUNCT
cajgh-231	100	20	the	the	DET
cajgh-231	100	21	presence	presence	NOUN
cajgh-231	100	22	of	of	ADP
cajgh-231	100	23	multiple	multiple	ADJ
cajgh-231	100	24	mtdna	mtdna	NOUN
cajgh-231	100	25	variants	variant	NOUN
cajgh-231	100	26	within	within	ADP
cajgh-231	100	27	a	a	DET
cajgh-231	100	28	cell	cell	NOUN
cajgh-231	100	29	)	)	PUNCT
cajgh-231	100	30	is	be	AUX
cajgh-231	100	31	now	now	ADV
cajgh-231	100	32	widely	widely	ADV
cajgh-231	100	33	appreciated.41	appreciated.41	ADJ
cajgh-231	100	34	thus	thus	ADV
cajgh-231	100	35	,	,	PUNCT
cajgh-231	100	36	undetected	undetecte	VERB
cajgh-231	100	37	lower	low	ADJ
cajgh-231	100	38	frequency	frequency	NOUN
cajgh-231	100	39	mtdna	mtdna	NOUN
cajgh-231	100	40	variants	variant	NOUN
cajgh-231	100	41	could	could	AUX
cajgh-231	100	42	potentially	potentially	ADV
cajgh-231	100	43	be	be	AUX
cajgh-231	100	44	involved	involve	VERB
cajgh-231	100	45	in	in	ADP
cajgh-231	100	46	the	the	DET
cajgh-231	100	47	transmission	transmission	NOUN
cajgh-231	100	48	of	of	ADP
cajgh-231	100	49	the	the	DET
cajgh-231	100	50	pd	pd	NOUN
cajgh-231	100	51	-	-	NOUN
cajgh-231	100	52	state	state	NOUN
cajgh-231	100	53	.	.	PUNCT
cajgh-231	101	1	additionally	additionally	ADV
cajgh-231	101	2	,	,	PUNCT
cajgh-231	101	3	the	the	DET
cajgh-231	101	4	number	number	NOUN
cajgh-231	101	5	of	of	ADP
cajgh-231	101	6	pd	pd	ADJ
cajgh-231	101	7	-	-	PUNCT
cajgh-231	101	8	state	state	NOUN
cajgh-231	101	9	triggering	trigger	VERB
cajgh-231	101	10	variants	variant	NOUN
cajgh-231	101	11	could	could	AUX
cajgh-231	101	12	be	be	AUX
cajgh-231	101	13	too	too	ADV
cajgh-231	101	14	large	large	ADJ
cajgh-231	101	15	for	for	ADP
cajgh-231	101	16	effective	effective	ADJ
cajgh-231	101	17	statistical	statistical	ADJ
cajgh-231	101	18	detection	detection	NOUN
cajgh-231	101	19	.	.	PUNCT
cajgh-231	102	1	alternatively	alternatively	ADV
cajgh-231	102	2	,	,	PUNCT
cajgh-231	102	3	the	the	DET
cajgh-231	102	4	pd	pd	NOUN
cajgh-231	102	5	-	-	PUNCT
cajgh-231	102	6	state	state	NOUN
cajgh-231	102	7	could	could	AUX
cajgh-231	102	8	be	be	AUX
cajgh-231	102	9	a	a	DET
cajgh-231	102	10	result	result	NOUN
cajgh-231	102	11	of	of	ADP
cajgh-231	102	12	mtdna	mtdna	X
cajgh-231	102	13	epigenetic	epigenetic	ADJ
cajgh-231	102	14	modifications	modification	NOUN
cajgh-231	102	15	.	.	PUNCT
cajgh-231	103	1	whether	whether	SCONJ
cajgh-231	103	2	mtdna	mtdna	NOUN
cajgh-231	103	3	can	can	AUX
cajgh-231	103	4	be	be	AUX
cajgh-231	103	5	methylated	methylate	VERB
cajgh-231	103	6	is	be	AUX
cajgh-231	103	7	currently	currently	ADV
cajgh-231	103	8	a	a	DET
cajgh-231	103	9	matter	matter	NOUN
cajgh-231	103	10	of	of	ADP
cajgh-231	103	11	active	active	ADJ
cajgh-231	103	12	debate.49,50	debate.49,50	NOUN
cajgh-231	103	13	hong	hong	PROPN
cajgh-231	103	14	et	et	PROPN
cajgh-231	103	15	al.51	al.51	PROPN
cajgh-231	103	16	make	make	VERB
cajgh-231	103	17	a	a	DET
cajgh-231	103	18	strong	strong	ADJ
cajgh-231	103	19	case	case	NOUN
cajgh-231	103	20	for	for	ADP
cajgh-231	103	21	the	the	DET
cajgh-231	103	22	absence	absence	NOUN
cajgh-231	103	23	of	of	ADP
cajgh-231	103	24	mtdna	mtdna	NOUN
cajgh-231	103	25	methylation	methylation	NOUN
cajgh-231	103	26	,	,	PUNCT
cajgh-231	103	27	at	at	ADP
cajgh-231	103	28	least	least	ADJ
cajgh-231	103	29	under	under	ADP
cajgh-231	103	30	most	most	ADJ
cajgh-231	103	31	biological	biological	ADJ
cajgh-231	103	32	conditions	condition	NOUN
cajgh-231	103	33	.	.	PUNCT
cajgh-231	104	1	on	on	ADP
cajgh-231	104	2	the	the	DET
cajgh-231	104	3	other	other	ADJ
cajgh-231	104	4	hand	hand	NOUN
cajgh-231	104	5	,	,	PUNCT
cajgh-231	104	6	a	a	DET
cajgh-231	104	7	recent	recent	ADJ
cajgh-231	104	8	publication	publication	NOUN
cajgh-231	104	9	by	by	ADP
cajgh-231	104	10	bacarelli	bacarelli	PROPN
cajgh-231	104	11	et	et	PROPN
cajgh-231	104	12	al.52	al.52	PROPN
cajgh-231	104	13	reports	report	VERB
cajgh-231	104	14	the	the	DET
cajgh-231	104	15	presence	presence	NOUN
cajgh-231	104	16	of	of	ADP
cajgh-231	104	17	significant	significant	ADJ
cajgh-231	104	18	mtdna	mtdna	NOUN
cajgh-231	104	19	methylation	methylation	NOUN
cajgh-231	104	20	in	in	ADP
cajgh-231	104	21	platelets	platelet	NOUN
cajgh-231	104	22	of	of	ADP
cajgh-231	104	23	cardiovascular	cardiovascular	ADJ
cajgh-231	104	24	disease	disease	NOUN
cajgh-231	104	25	patients	patient	NOUN
cajgh-231	104	26	.	.	PUNCT
cajgh-231	105	1	for	for	ADP
cajgh-231	105	2	instance	instance	NOUN
cajgh-231	105	3	,	,	PUNCT
cajgh-231	105	4	in	in	ADP
cajgh-231	105	5	sequenced	sequenced	ADJ
cajgh-231	105	6	sites	site	NOUN
cajgh-231	105	7	in	in	ADP
cajgh-231	105	8	the	the	DET
cajgh-231	105	9	mt	mt	PROPN
cajgh-231	105	10	-	-	PUNCT
cajgh-231	105	11	co1	co1	PROPN
cajgh-231	105	12	gene	gene	NOUN
cajgh-231	105	13	region	region	NOUN
cajgh-231	105	14	,	,	PUNCT
cajgh-231	105	15	bacarelli	bacarelli	PROPN
cajgh-231	105	16	et	et	PROPN
cajgh-231	105	17	al	al	PROPN
cajgh-231	105	18	.	.	PROPN
cajgh-231	105	19	report	report	PROPN
cajgh-231	105	20	average	average	ADJ
cajgh-231	105	21	percentage	percentage	NOUN
cajgh-231	105	22	site	site	NOUN
cajgh-231	105	23	methylation	methylation	NOUN
cajgh-231	105	24	to	to	PART
cajgh-231	105	25	be	be	AUX
cajgh-231	105	26	on	on	ADP
cajgh-231	105	27	the	the	DET
cajgh-231	105	28	order	order	NOUN
cajgh-231	105	29	of	of	ADP
cajgh-231	105	30	25%.52	25%.52	NUM
cajgh-231	105	31	a	a	DET
cajgh-231	105	32	site	site	NOUN
cajgh-231	105	33	of	of	ADP
cajgh-231	105	34	origin	origin	NOUN
cajgh-231	105	35	for	for	ADP
cajgh-231	105	36	the	the	DET
cajgh-231	105	37	pd	pd	NOUN
cajgh-231	105	38	-	-	NOUN
cajgh-231	105	39	state	state	NOUN
cajgh-231	105	40	we	we	PRON
cajgh-231	105	41	have	have	AUX
cajgh-231	105	42	mentioned	mention	VERB
cajgh-231	105	43	that	that	SCONJ
cajgh-231	105	44	ageing	age	VERB
cajgh-231	105	45	-	-	PUNCT
cajgh-231	105	46	associated	associate	VERB
cajgh-231	105	47	damage	damage	NOUN
cajgh-231	105	48	caused	cause	VERB
cajgh-231	105	49	by	by	ADP
cajgh-231	105	50	oxidative	oxidative	ADJ
cajgh-231	105	51	stress	stress	NOUN
cajgh-231	105	52	in	in	ADP
cajgh-231	105	53	mitochondria	mitochondria	NOUN
cajgh-231	105	54	could	could	AUX
cajgh-231	105	55	be	be	AUX
cajgh-231	105	56	the	the	DET
cajgh-231	105	57	trigger	trigger	NOUN
cajgh-231	105	58	for	for	ADP
cajgh-231	105	59	a	a	DET
cajgh-231	105	60	primordial	primordial	ADJ
cajgh-231	105	61	cell	cell	NOUN
cajgh-231	105	62	to	to	PART
cajgh-231	105	63	shift	shift	VERB
cajgh-231	105	64	its	its	PRON
cajgh-231	105	65	gene	gene	NOUN
cajgh-231	105	66	expression	expression	NOUN
cajgh-231	105	67	program	program	NOUN
cajgh-231	105	68	to	to	ADP
cajgh-231	105	69	the	the	DET
cajgh-231	105	70	pd	pd	NOUN
cajgh-231	105	71	-	-	NOUN
cajgh-231	105	72	state	state	NOUN
cajgh-231	105	73	.	.	PUNCT
cajgh-231	106	1	the	the	DET
cajgh-231	106	2	next	next	ADJ
cajgh-231	106	3	relevant	relevant	ADJ
cajgh-231	106	4	question	question	NOUN
cajgh-231	106	5	is	be	AUX
cajgh-231	106	6	:	:	PUNCT
cajgh-231	106	7	where	where	SCONJ
cajgh-231	106	8	would	would	AUX
cajgh-231	106	9	an	an	DET
cajgh-231	106	10	initial	initial	ADJ
cajgh-231	106	11	pd	pd	ADJ
cajgh-231	106	12	-	-	PUNCT
cajgh-231	106	13	state	state	NOUN
cajgh-231	106	14	cell	cell	NOUN
cajgh-231	106	15	most	most	ADV
cajgh-231	106	16	commonly	commonly	ADV
cajgh-231	106	17	arise	arise	VERB
cajgh-231	106	18	?	?	PUNCT
cajgh-231	107	1	in	in	ADP
cajgh-231	107	2	this	this	DET
cajgh-231	107	3	section	section	NOUN
cajgh-231	107	4	,	,	PUNCT
cajgh-231	107	5	we	we	PRON
cajgh-231	107	6	suggest	suggest	VERB
cajgh-231	107	7	the	the	DET
cajgh-231	107	8	hematopoietic	hematopoietic	ADJ
cajgh-231	107	9	stem	stem	NOUN
cajgh-231	107	10	cell	cell	NOUN
cajgh-231	107	11	niche	niche	NOUN
cajgh-231	107	12	as	as	ADP
cajgh-231	107	13	a	a	DET
cajgh-231	107	14	site	site	NOUN
cajgh-231	107	15	to	to	PART
cajgh-231	107	16	consider	consider	VERB
cajgh-231	107	17	.	.	PUNCT
cajgh-231	108	1	research	research	NOUN
cajgh-231	108	2	based	base	VERB
cajgh-231	108	3	on	on	ADP
cajgh-231	108	4	gene	gene	NOUN
cajgh-231	108	5	expression,18,25	expression,18,25	PROPN
cajgh-231	108	6	dna	dna	PROPN
cajgh-231	108	7	methylation,27	methylation,27	PROPN
cajgh-231	108	8	neuron	neuron	NOUN
cajgh-231	108	9	-	-	PUNCT
cajgh-231	108	10	platelet	platelet	NOUN
cajgh-231	108	11	cybrid,15,42,43	cybrid,15,42,43	NOUN
cajgh-231	108	12	and	and	CCONJ
cajgh-231	108	13	bioenergetic33	bioenergetic33	NOUN
cajgh-231	108	14	analyses	analysis	NOUN
cajgh-231	108	15	supports	support	VERB
cajgh-231	108	16	the	the	DET
cajgh-231	108	17	presence	presence	NOUN
cajgh-231	108	18	of	of	ADP
cajgh-231	108	19	the	the	DET
cajgh-231	108	20	pdstate	pdstate	NOUN
cajgh-231	108	21	in	in	ADP
cajgh-231	108	22	circulating	circulate	VERB
cajgh-231	108	23	hematopoietic	hematopoietic	ADJ
cajgh-231	108	24	cells	cell	NOUN
cajgh-231	108	25	.	.	PUNCT
cajgh-231	109	1	given	give	VERB
cajgh-231	109	2	the	the	DET
cajgh-231	109	3	short	short	ADJ
cajgh-231	109	4	lifespan	lifespan	NOUN
cajgh-231	109	5	of	of	ADP
cajgh-231	109	6	blood	blood	NOUN
cajgh-231	109	7	cells	cell	NOUN
cajgh-231	109	8	(	(	PUNCT
cajgh-231	109	9	days	day	NOUN
cajgh-231	109	10	for	for	ADP
cajgh-231	109	11	platelets53	platelets53	NOUN
cajgh-231	109	12	and	and	CCONJ
cajgh-231	109	13	granulocytes54	granulocytes54	NOUN
cajgh-231	109	14	and	and	CCONJ
cajgh-231	109	15	weeks	week	NOUN
cajgh-231	109	16	for	for	ADP
cajgh-231	109	17	lymphocytes	lymphocyte	NOUN
cajgh-231	109	18	,	,	PUNCT
cajgh-231	109	19	with	with	ADP
cajgh-231	109	20	the	the	DET
cajgh-231	109	21	exception	exception	NOUN
cajgh-231	109	22	of	of	ADP
cajgh-231	109	23	memory	memory	NOUN
cajgh-231	109	24	cells55	cells55	NOUN
cajgh-231	109	25	)	)	PUNCT
cajgh-231	109	26	by	by	ADP
cajgh-231	109	27	comparison	comparison	NOUN
cajgh-231	109	28	with	with	ADP
cajgh-231	109	29	the	the	DET
cajgh-231	109	30	decade	decade	NOUN
cajgh-231	109	31	long	long	ADJ
cajgh-231	109	32	timescale	timescale	NOUN
cajgh-231	109	33	for	for	ADP
cajgh-231	109	34	the	the	DET
cajgh-231	109	35	transmission	transmission	NOUN
cajgh-231	109	36	of	of	ADP
cajgh-231	109	37	pd	pd	PROPN
cajgh-231	109	38	across	across	ADP
cajgh-231	109	39	the	the	DET
cajgh-231	109	40	neuronal	neuronal	ADJ
cajgh-231	109	41	system,36	system,36	NOUN
cajgh-231	109	42	-	-	PUNCT
cajgh-231	109	43	38	38	NUM
cajgh-231	109	44	the	the	DET
cajgh-231	109	45	above	above	ADJ
cajgh-231	109	46	signs	sign	NOUN
cajgh-231	109	47	of	of	ADP
cajgh-231	109	48	pd	pd	PROPN
cajgh-231	109	49	in	in	ADP
cajgh-231	109	50	blood	blood	NOUN
cajgh-231	109	51	point	point	NOUN
cajgh-231	109	52	to	to	ADP
cajgh-231	109	53	circulating	circulate	VERB
cajgh-231	109	54	hematopoietic	hematopoietic	ADJ
cajgh-231	109	55	cells	cell	NOUN
cajgh-231	109	56	acquiring	acquire	VERB
cajgh-231	109	57	the	the	DET
cajgh-231	109	58	pd	pd	NOUN
cajgh-231	109	59	-	-	NOUN
cajgh-231	109	60	state	state	NOUN
cajgh-231	109	61	at	at	ADP
cajgh-231	109	62	hematopoiesis	hematopoiesis	NOUN
cajgh-231	109	63	,	,	PUNCT
cajgh-231	109	64	rather	rather	ADV
cajgh-231	109	65	than	than	ADP
cajgh-231	109	66	after	after	ADP
cajgh-231	109	67	maturation	maturation	NOUN
cajgh-231	109	68	.	.	PUNCT
cajgh-231	110	1	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	110	2	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	110	3	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	X
cajgh-231	111	1	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	111	2	central	central	ADJ
cajgh-231	111	3	asian	asian	ADJ
cajgh-231	111	4	journal	journal	NOUN
cajgh-231	111	5	of	of	ADP
cajgh-231	111	6	global	global	ADJ
cajgh-231	111	7	health	health	NOUN
cajgh-231	111	8	this	this	DET
cajgh-231	111	9	work	work	NOUN
cajgh-231	111	10	is	be	AUX
cajgh-231	111	11	licensed	license	VERB
cajgh-231	111	12	under	under	ADP
cajgh-231	111	13	a	a	DET
cajgh-231	111	14	creative	creative	ADJ
cajgh-231	111	15	commons	common	NOUN
cajgh-231	111	16	attribution	attribution	NOUN
cajgh-231	111	17	4.0	4.0	NUM
cajgh-231	111	18	united	unite	VERB
cajgh-231	111	19	states	states	PROPN
cajgh-231	111	20	license	license	NOUN
cajgh-231	111	21	.	.	PUNCT
cajgh-231	112	1	this	this	DET
cajgh-231	112	2	journal	journal	NOUN
cajgh-231	112	3	is	be	AUX
cajgh-231	112	4	published	publish	VERB
cajgh-231	112	5	by	by	ADP
cajgh-231	112	6	theuniversity	theuniversity	NOUN
cajgh-231	112	7	library	library	NOUN
cajgh-231	112	8	system	system	NOUN
cajgh-231	112	9	of	of	ADP
cajgh-231	112	10	the	the	DET
cajgh-231	112	11	university	university	PROPN
cajgh-231	112	12	of	of	ADP
cajgh-231	112	13	pittsburgh	pittsburgh	PROPN
cajgh-231	112	14	as	as	ADP
cajgh-231	112	15	part	part	NOUN
cajgh-231	112	16	of	of	ADP
cajgh-231	112	17	its	its	PRON
cajgh-231	112	18	d	d	NOUN
cajgh-231	112	19	-	-	PUNCT
cajgh-231	112	20	scribe	scribe	VERB
cajgh-231	112	21	digital	digital	ADJ
cajgh-231	112	22	publishing	publishing	NOUN
cajgh-231	112	23	program	program	NOUN
cajgh-231	112	24	and	and	CCONJ
cajgh-231	112	25	is	be	AUX
cajgh-231	112	26	cosponsored	cosponsor	VERB
cajgh-231	112	27	by	by	ADP
cajgh-231	112	28	the	the	DET
cajgh-231	112	29	university	university	PROPN
cajgh-231	112	30	of	of	ADP
cajgh-231	112	31	pittsburgh	pittsburgh	PROPN
cajgh-231	112	32	press	press	NOUN
cajgh-231	112	33	.	.	PUNCT
cajgh-231	113	1	central	central	ADJ
cajgh-231	113	2	asian	asian	ADJ
cajgh-231	113	3	journal	journal	NOUN
cajgh-231	113	4	of	of	ADP
cajgh-231	113	5	global	global	ADJ
cajgh-231	113	6	health	health	NOUN
cajgh-231	113	7	volume	volume	NOUN
cajgh-231	113	8	4	4	NUM
cajgh-231	113	9	,	,	PUNCT
cajgh-231	113	10	no	no	INTJ
cajgh-231	113	11	.	.	NOUN
cajgh-231	113	12	1	1	NUM
cajgh-231	113	13	(	(	PUNCT
cajgh-231	113	14	2015	2015	NUM
cajgh-231	113	15	)	)	PUNCT
cajgh-231	113	16	|	|	ADV
cajgh-231	113	17	issn	issn	VERB
cajgh-231	113	18	2166	2166	NUM
cajgh-231	113	19	-	-	SYM
cajgh-231	113	20	7403	7403	NUM
cajgh-231	113	21	(	(	PUNCT
cajgh-231	113	22	online	online	ADJ
cajgh-231	113	23	)	)	PUNCT
cajgh-231	113	24	|	|	ADV
cajgh-231	113	25	doi	doi	X
cajgh-231	113	26	10.5195	10.5195	NUM
cajgh-231	113	27	/	/	SYM
cajgh-231	113	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	113	29	hematopoiesis	hematopoiesis	NOUN
cajgh-231	113	30	is	be	AUX
cajgh-231	113	31	altered	alter	VERB
cajgh-231	113	32	with	with	ADP
cajgh-231	113	33	ageing	age	VERB
cajgh-231	113	34	.	.	PUNCT
cajgh-231	114	1	in	in	ADP
cajgh-231	114	2	terms	term	NOUN
cajgh-231	114	3	of	of	ADP
cajgh-231	114	4	global	global	ADJ
cajgh-231	114	5	gene	gene	NOUN
cajgh-231	114	6	expression	expression	NOUN
cajgh-231	114	7	in	in	ADP
cajgh-231	114	8	hematopoietic	hematopoietic	ADJ
cajgh-231	114	9	stem	stem	NOUN
cajgh-231	114	10	cells	cell	NOUN
cajgh-231	114	11	(	(	PUNCT
cajgh-231	114	12	hscs	hsc	NOUN
cajgh-231	114	13	)	)	PUNCT
cajgh-231	114	14	,	,	PUNCT
cajgh-231	114	15	nitric	nitric	ADJ
cajgh-231	114	16	oxide	oxide	NOUN
cajgh-231	114	17	mediated	mediate	VERB
cajgh-231	114	18	signal	signal	NOUN
cajgh-231	114	19	transduction	transduction	NOUN
cajgh-231	114	20	,	,	PUNCT
cajgh-231	114	21	the	the	DET
cajgh-231	114	22	nf	nf	ADJ
cajgh-231	114	23	-	-	PUNCT
cajgh-231	114	24	kb	kb	NOUN
cajgh-231	114	25	cascade	cascade	NOUN
cajgh-231	114	26	and	and	CCONJ
cajgh-231	114	27	the	the	DET
cajgh-231	114	28	pro	pro	ADJ
cajgh-231	114	29	-	-	ADJ
cajgh-231	114	30	inflammatory	inflammatory	ADJ
cajgh-231	114	31	response	response	NOUN
cajgh-231	114	32	are	be	AUX
cajgh-231	114	33	the	the	DET
cajgh-231	114	34	most	most	ADJ
cajgh-231	114	35	age	age	NOUN
cajgh-231	114	36	up	up	ADV
cajgh-231	114	37	-	-	PUNCT
cajgh-231	114	38	regulated	regulate	VERB
cajgh-231	114	39	processes	process	NOUN
cajgh-231	114	40	,	,	PUNCT
cajgh-231	114	41	while	while	SCONJ
cajgh-231	114	42	chromatin	chromatin	NOUN
cajgh-231	114	43	silencing	silencing	NOUN
cajgh-231	114	44	,	,	PUNCT
cajgh-231	114	45	single	single	ADJ
cajgh-231	114	46	-	-	PUNCT
cajgh-231	114	47	strand	strand	NOUN
cajgh-231	114	48	break	break	NOUN
cajgh-231	114	49	repair	repair	NOUN
cajgh-231	114	50	,	,	PUNCT
cajgh-231	114	51	smad	smad	NOUN
cajgh-231	114	52	protein	protein	NOUN
cajgh-231	114	53	nuclear	nuclear	ADJ
cajgh-231	114	54	translocation	translocation	NOUN
cajgh-231	114	55	and	and	CCONJ
cajgh-231	114	56	chromatin	chromatin	NOUN
cajgh-231	114	57	remodeling	remodeling	NOUN
cajgh-231	114	58	are	be	AUX
cajgh-231	114	59	the	the	DET
cajgh-231	114	60	most	most	ADV
cajgh-231	114	61	down	down	ADV
cajgh-231	114	62	-	-	PUNCT
cajgh-231	114	63	regulated	regulate	VERB
cajgh-231	114	64	ones.56	ones.56	ADJ
cajgh-231	114	65	alterations	alteration	NOUN
cajgh-231	114	66	at	at	ADP
cajgh-231	114	67	the	the	DET
cajgh-231	114	68	hsc	hsc	PROPN
cajgh-231	114	69	epigenetic	epigenetic	ADJ
cajgh-231	114	70	level	level	NOUN
cajgh-231	114	71	are	be	AUX
cajgh-231	114	72	supported	support	VERB
cajgh-231	114	73	by	by	ADP
cajgh-231	114	74	many	many	ADJ
cajgh-231	114	75	chromosomal	chromosomal	ADJ
cajgh-231	114	76	regions	region	NOUN
cajgh-231	114	77	showing	show	VERB
cajgh-231	114	78	a	a	DET
cajgh-231	114	79	coordinated	coordinated	ADJ
cajgh-231	114	80	change	change	NOUN
cajgh-231	114	81	in	in	ADP
cajgh-231	114	82	transcriptional	transcriptional	NOUN
cajgh-231	114	83	activity.56	activity.56	NOUN
cajgh-231	114	84	fate	fate	NOUN
cajgh-231	114	85	-	-	PUNCT
cajgh-231	114	86	wise	wise	ADJ
cajgh-231	114	87	,	,	PUNCT
cajgh-231	114	88	a	a	DET
cajgh-231	114	89	skewing	skewing	NOUN
cajgh-231	114	90	to	to	ADP
cajgh-231	114	91	the	the	DET
cajgh-231	114	92	myeloid	myeloid	ADJ
cajgh-231	114	93	line	line	NOUN
cajgh-231	114	94	and	and	CCONJ
cajgh-231	114	95	a	a	DET
cajgh-231	114	96	diminished	diminished	ADJ
cajgh-231	114	97	lymphoid	lymphoid	NOUN
cajgh-231	114	98	potential	potential	NOUN
cajgh-231	114	99	are	be	AUX
cajgh-231	114	100	observed	observe	VERB
cajgh-231	114	101	with	with	ADP
cajgh-231	114	102	ageing.57	ageing.57	NOUN
cajgh-231	114	103	it	it	PRON
cajgh-231	114	104	has	have	AUX
cajgh-231	114	105	been	be	AUX
cajgh-231	114	106	known	know	VERB
cajgh-231	114	107	for	for	ADP
cajgh-231	114	108	a	a	DET
cajgh-231	114	109	long	long	ADJ
cajgh-231	114	110	time	time	NOUN
cajgh-231	114	111	that	that	PRON
cajgh-231	114	112	reactive	reactive	ADJ
cajgh-231	114	113	oxygen	oxygen	NOUN
cajgh-231	114	114	species	specie	NOUN
cajgh-231	114	115	(	(	PUNCT
cajgh-231	114	116	ros	ros	PROPN
cajgh-231	114	117	)	)	PUNCT
cajgh-231	114	118	,	,	PUNCT
cajgh-231	114	119	if	if	SCONJ
cajgh-231	114	120	not	not	PART
cajgh-231	114	121	properly	properly	ADV
cajgh-231	114	122	checked	check	VERB
cajgh-231	114	123	,	,	PUNCT
cajgh-231	114	124	have	have	VERB
cajgh-231	114	125	the	the	DET
cajgh-231	114	126	potential	potential	NOUN
cajgh-231	114	127	to	to	PART
cajgh-231	114	128	cause	cause	VERB
cajgh-231	114	129	indiscriminate	indiscriminate	ADJ
cajgh-231	114	130	cellular	cellular	ADJ
cajgh-231	114	131	damage.30	damage.30	NOUN
cajgh-231	114	132	today	today	NOUN
cajgh-231	114	133	,	,	PUNCT
cajgh-231	114	134	it	it	PRON
cajgh-231	114	135	is	be	AUX
cajgh-231	114	136	recognized	recognize	VERB
cajgh-231	114	137	that	that	SCONJ
cajgh-231	114	138	ros	ros	PROPN
cajgh-231	114	139	may	may	AUX
cajgh-231	114	140	also	also	ADV
cajgh-231	114	141	play	play	VERB
cajgh-231	114	142	a	a	DET
cajgh-231	114	143	functional	functional	ADJ
cajgh-231	114	144	signaling	signal	VERB
cajgh-231	114	145	role	role	NOUN
cajgh-231	114	146	in	in	ADP
cajgh-231	114	147	activating	activate	VERB
cajgh-231	114	148	processes	process	NOUN
cajgh-231	114	149	such	such	ADJ
cajgh-231	114	150	as	as	ADP
cajgh-231	114	151	the	the	DET
cajgh-231	114	152	inflammatory	inflammatory	ADJ
cajgh-231	114	153	and	and	CCONJ
cajgh-231	114	154	stress	stress	NOUN
cajgh-231	114	155	responses.28,58	responses.28,58	NOUN
cajgh-231	114	156	additionally	additionally	ADV
cajgh-231	114	157	,	,	PUNCT
cajgh-231	114	158	there	there	PRON
cajgh-231	114	159	is	be	VERB
cajgh-231	114	160	indication	indication	NOUN
cajgh-231	114	161	that	that	SCONJ
cajgh-231	114	162	ros	ros	PROPN
cajgh-231	114	163	play	play	VERB
cajgh-231	114	164	a	a	DET
cajgh-231	114	165	role	role	NOUN
cajgh-231	114	166	in	in	ADP
cajgh-231	114	167	regulating	regulate	VERB
cajgh-231	114	168	hematopoiesis.59	hematopoiesis.59	PROPN
cajgh-231	114	169	in	in	ADP
cajgh-231	114	170	particular	particular	ADJ
cajgh-231	114	171	,	,	PUNCT
cajgh-231	114	172	evidence	evidence	NOUN
cajgh-231	114	173	associates	associate	NOUN
cajgh-231	114	174	abnormal	abnormal	ADJ
cajgh-231	114	175	ros	ros	PROPN
cajgh-231	114	176	levels	level	NOUN
cajgh-231	114	177	at	at	ADP
cajgh-231	114	178	old	old	ADJ
cajgh-231	114	179	age	age	NOUN
cajgh-231	114	180	with	with	ADP
cajgh-231	114	181	a	a	DET
cajgh-231	114	182	dysfunction	dysfunction	NOUN
cajgh-231	114	183	in	in	ADP
cajgh-231	114	184	both	both	CCONJ
cajgh-231	114	185	the	the	DET
cajgh-231	114	186	proliferation	proliferation	NOUN
cajgh-231	114	187	and	and	CCONJ
cajgh-231	114	188	the	the	DET
cajgh-231	114	189	differentiation	differentiation	NOUN
cajgh-231	114	190	dynamics	dynamic	NOUN
cajgh-231	114	191	of	of	ADP
cajgh-231	114	192	hscs	hsc	NOUN
cajgh-231	114	193	.	.	PUNCT
cajgh-231	115	1	in	in	ADP
cajgh-231	115	2	vitro	vitro	X
cajgh-231	115	3	research	research	NOUN
cajgh-231	115	4	has	have	AUX
cajgh-231	115	5	shown	show	VERB
cajgh-231	115	6	that	that	DET
cajgh-231	115	7	exposure	exposure	NOUN
cajgh-231	115	8	to	to	ADP
cajgh-231	115	9	h2o2	h2o2	PROPN
cajgh-231	115	10	can	can	AUX
cajgh-231	115	11	lead	lead	VERB
cajgh-231	115	12	to	to	ADP
cajgh-231	115	13	chromosomal	chromosomal	ADJ
cajgh-231	115	14	translocations	translocation	NOUN
cajgh-231	115	15	in	in	ADP
cajgh-231	115	16	hscs.60	hscs.60	NOUN
cajgh-231	115	17	ionizing	ionize	VERB
cajgh-231	115	18	radiation	radiation	NOUN
cajgh-231	115	19	is	be	AUX
cajgh-231	115	20	also	also	ADV
cajgh-231	115	21	known	know	VERB
cajgh-231	115	22	to	to	PART
cajgh-231	115	23	affect	affect	VERB
cajgh-231	115	24	hscs	hsc	NOUN
cajgh-231	115	25	,	,	PUNCT
cajgh-231	115	26	as	as	SCONJ
cajgh-231	115	27	it	it	PRON
cajgh-231	115	28	has	have	AUX
cajgh-231	115	29	been	be	AUX
cajgh-231	115	30	found	find	VERB
cajgh-231	115	31	to	to	PART
cajgh-231	115	32	promote	promote	VERB
cajgh-231	115	33	differentiation	differentiation	NOUN
cajgh-231	115	34	,	,	PUNCT
cajgh-231	115	35	short	short	ADJ
cajgh-231	115	36	-	-	PUNCT
cajgh-231	115	37	term	term	NOUN
cajgh-231	115	38	apoptosis	apoptosis	NOUN
cajgh-231	115	39	and	and	CCONJ
cajgh-231	115	40	long	long	ADJ
cajgh-231	115	41	-	-	PUNCT
cajgh-231	115	42	term	term	NOUN
cajgh-231	115	43	senescence	senescence	NOUN
cajgh-231	115	44	of	of	ADP
cajgh-231	115	45	hscs.61	hscs.61	NOUN
cajgh-231	115	46	work	work	NOUN
cajgh-231	115	47	with	with	ADP
cajgh-231	115	48	drosophila	drosophila	PROPN
cajgh-231	115	49	supports	support	VERB
cajgh-231	115	50	the	the	DET
cajgh-231	115	51	role	role	NOUN
cajgh-231	115	52	of	of	ADP
cajgh-231	115	53	ros	ros	PROPN
cajgh-231	115	54	in	in	ADP
cajgh-231	115	55	the	the	DET
cajgh-231	115	56	regulation	regulation	NOUN
cajgh-231	115	57	of	of	ADP
cajgh-231	115	58	hematopoietic	hematopoietic	ADJ
cajgh-231	115	59	cell	cell	NOUN
cajgh-231	115	60	fate	fate	NOUN
cajgh-231	115	61	.	.	PUNCT
cajgh-231	116	1	increasing	increase	VERB
cajgh-231	116	2	ros	ros	PROPN
cajgh-231	116	3	beyond	beyond	ADP
cajgh-231	116	4	its	its	PRON
cajgh-231	116	5	basal	basal	ADJ
cajgh-231	116	6	level	level	NOUN
cajgh-231	116	7	in	in	ADP
cajgh-231	116	8	drosophila	drosophila	NOUN
cajgh-231	116	9	multipotent	multipotent	NOUN
cajgh-231	116	10	hematopoietic	hematopoietic	ADJ
cajgh-231	116	11	progenitor	progenitor	NOUN
cajgh-231	116	12	cells	cell	NOUN
cajgh-231	116	13	triggers	trigger	VERB
cajgh-231	116	14	their	their	PRON
cajgh-231	116	15	precocious	precocious	ADJ
cajgh-231	116	16	differentiation.62	differentiation.62	NOUN
cajgh-231	116	17	conversely	conversely	ADV
cajgh-231	116	18	,	,	PUNCT
cajgh-231	116	19	scavenging	scavenge	VERB
cajgh-231	116	20	ros	ros	PROPN
cajgh-231	116	21	from	from	ADP
cajgh-231	116	22	these	these	DET
cajgh-231	116	23	hematopoietic	hematopoietic	ADJ
cajgh-231	116	24	progenitors	progenitor	NOUN
cajgh-231	116	25	retards	retard	VERB
cajgh-231	116	26	their	their	PRON
cajgh-231	116	27	differentiation	differentiation	NOUN
cajgh-231	116	28	into	into	ADP
cajgh-231	116	29	mature	mature	ADJ
cajgh-231	116	30	blood	blood	NOUN
cajgh-231	116	31	cells.62	cells.62	NOUN
cajgh-231	116	32	it	it	PRON
cajgh-231	116	33	is	be	AUX
cajgh-231	116	34	wellestablished	wellestablishe	VERB
cajgh-231	116	35	that	that	SCONJ
cajgh-231	116	36	serial	serial	ADJ
cajgh-231	116	37	transplantation	transplantation	NOUN
cajgh-231	116	38	of	of	ADP
cajgh-231	116	39	human	human	ADJ
cajgh-231	116	40	hscs	hsc	NOUN
cajgh-231	116	41	into	into	ADP
cajgh-231	116	42	immunodeficient	immunodeficient	NOUN
cajgh-231	116	43	mice	mouse	NOUN
cajgh-231	116	44	leads	lead	VERB
cajgh-231	116	45	to	to	ADP
cajgh-231	116	46	both	both	DET
cajgh-231	116	47	elevated	elevated	ADJ
cajgh-231	116	48	intracellular	intracellular	ADJ
cajgh-231	116	49	ros	ros	NOUN
cajgh-231	116	50	levels	level	NOUN
cajgh-231	116	51	and	and	CCONJ
cajgh-231	116	52	to	to	PART
cajgh-231	116	53	premature	premature	VERB
cajgh-231	116	54	hsc	hsc	PROPN
cajgh-231	116	55	senescence.63	senescence.63	PROPN
cajgh-231	116	56	-	-	PUNCT
cajgh-231	116	57	65	65	NUM
cajgh-231	116	58	yahata	yahata	NOUN
cajgh-231	116	59	et	et	NOUN
cajgh-231	116	60	al.63	al.63	PROPN
cajgh-231	116	61	and	and	CCONJ
cajgh-231	116	62	ito	ito	PROPN
cajgh-231	116	63	et	et	PROPN
cajgh-231	116	64	al.65	al.65	PROPN
cajgh-231	116	65	independently	independently	ADV
cajgh-231	116	66	reported	report	VERB
cajgh-231	116	67	that	that	SCONJ
cajgh-231	116	68	antioxidant	antioxidant	ADJ
cajgh-231	116	69	pharmacological	pharmacological	NOUN
cajgh-231	116	70	inhibition	inhibition	NOUN
cajgh-231	116	71	of	of	ADP
cajgh-231	116	72	ros	ros	PROPN
cajgh-231	116	73	can	can	AUX
cajgh-231	116	74	mitigate	mitigate	VERB
cajgh-231	116	75	this	this	DET
cajgh-231	116	76	deteriorating	deteriorate	VERB
cajgh-231	116	77	hsc	hsc	NOUN
cajgh-231	116	78	phenotype	phenotype	NOUN
cajgh-231	116	79	.	.	PUNCT
cajgh-231	117	1	caloric	caloric	NOUN
cajgh-231	117	2	restriction	restriction	NOUN
cajgh-231	117	3	in	in	ADP
cajgh-231	117	4	balbc	balbc	PROPN
cajgh-231	117	5	mice	mouse	NOUN
cajgh-231	117	6	was	be	AUX
cajgh-231	117	7	similarly	similarly	ADV
cajgh-231	117	8	shown	show	VERB
cajgh-231	117	9	to	to	PART
cajgh-231	117	10	postpone	postpone	VERB
cajgh-231	117	11	hsc	hsc	PROPN
cajgh-231	117	12	senescence.64	senescence.64	PROPN
cajgh-231	117	13	finally	finally	ADV
cajgh-231	117	14	,	,	PUNCT
cajgh-231	117	15	the	the	DET
cajgh-231	117	16	same	same	ADJ
cajgh-231	117	17	protective	protective	ADJ
cajgh-231	117	18	effect	effect	NOUN
cajgh-231	117	19	was	be	AUX
cajgh-231	117	20	achieved	achieve	VERB
cajgh-231	117	21	by	by	ADP
cajgh-231	117	22	sirt3	sirt3	PROPN
cajgh-231	117	23	upregulation	upregulation	NOUN
cajgh-231	117	24	in	in	ADP
cajgh-231	117	25	hscs.66	hscs.66	NOUN
cajgh-231	117	26	hscs	hsc	NOUN
cajgh-231	117	27	are	be	AUX
cajgh-231	117	28	highly	highly	ADV
cajgh-231	117	29	-	-	PUNCT
cajgh-231	117	30	enriched	enrich	VERB
cajgh-231	117	31	in	in	ADP
cajgh-231	117	32	this	this	DET
cajgh-231	117	33	mammalian	mammalian	ADJ
cajgh-231	117	34	sirtuin	sirtuin	NOUN
cajgh-231	117	35	,	,	PUNCT
cajgh-231	117	36	except	except	SCONJ
cajgh-231	117	37	for	for	ADP
cajgh-231	117	38	its	its	PRON
cajgh-231	117	39	suppressionat	suppressionat	ADJ
cajgh-231	117	40	old	old	ADJ
cajgh-231	117	41	age.66	age.66	NOUN
cajgh-231	117	42	sirt3	sirt3	PROPN
cajgh-231	117	43	regulates	regulate	VERB
cajgh-231	117	44	the	the	DET
cajgh-231	117	45	global	global	ADJ
cajgh-231	117	46	acetylation	acetylation	NOUN
cajgh-231	117	47	landscape	landscape	NOUN
cajgh-231	117	48	of	of	ADP
cajgh-231	117	49	mitochondrial	mitochondrial	ADJ
cajgh-231	117	50	proteins	protein	NOUN
cajgh-231	117	51	and	and	CCONJ
cajgh-231	117	52	reduces	reduce	VERB
cajgh-231	117	53	oxidative	oxidative	ADJ
cajgh-231	117	54	stress.66	stress.66	NOUN
cajgh-231	117	55	mechanistically	mechanistically	ADV
cajgh-231	117	56	,	,	PUNCT
cajgh-231	117	57	the	the	DET
cajgh-231	117	58	foxo	foxo	ADJ
cajgh-231	117	59	transcription	transcription	NOUN
cajgh-231	117	60	factors67	factors67	NOUN
cajgh-231	117	61	and	and	CCONJ
cajgh-231	117	62	the	the	DET
cajgh-231	117	63	p53,68	p53,68	PROPN
cajgh-231	117	64	akt,69	akt,69	ADJ
cajgh-231	117	65	mapk,65	mapk,65	PROPN
cajgh-231	117	66	and	and	CCONJ
cajgh-231	117	67	atm70	atm70	ADJ
cajgh-231	117	68	pathways	pathway	NOUN
cajgh-231	117	69	have	have	AUX
cajgh-231	117	70	all	all	ADV
cajgh-231	117	71	been	be	AUX
cajgh-231	117	72	implicated	implicate	VERB
cajgh-231	117	73	in	in	ADP
cajgh-231	117	74	the	the	DET
cajgh-231	117	75	ros	ros	PROPN
cajgh-231	117	76	modulation	modulation	NOUN
cajgh-231	117	77	of	of	ADP
cajgh-231	117	78	hematopoiesis	hematopoiesis	NOUN
cajgh-231	117	79	.	.	PUNCT
cajgh-231	118	1	at	at	ADP
cajgh-231	118	2	the	the	DET
cajgh-231	118	3	genetic	genetic	ADJ
cajgh-231	118	4	level	level	NOUN
cajgh-231	118	5	,	,	PUNCT
cajgh-231	118	6	emerging	emerge	VERB
cajgh-231	118	7	evidence	evidence	NOUN
cajgh-231	118	8	may	may	AUX
cajgh-231	118	9	also	also	ADV
cajgh-231	118	10	connect	connect	VERB
cajgh-231	118	11	pd	pd	PROPN
cajgh-231	118	12	and	and	CCONJ
cajgh-231	118	13	the	the	DET
cajgh-231	118	14	hematopoietic	hematopoietic	ADJ
cajgh-231	118	15	system	system	NOUN
cajgh-231	118	16	,	,	PUNCT
cajgh-231	118	17	although	although	SCONJ
cajgh-231	118	18	its	its	PRON
cajgh-231	118	19	interpretation	interpretation	NOUN
cajgh-231	118	20	is	be	AUX
cajgh-231	118	21	not	not	PART
cajgh-231	118	22	yet	yet	ADV
cajgh-231	118	23	completely	completely	ADV
cajgh-231	118	24	clear	clear	ADJ
cajgh-231	118	25	.	.	PUNCT
cajgh-231	119	1	a	a	DET
cajgh-231	119	2	new	new	ADJ
cajgh-231	119	3	study	study	NOUN
cajgh-231	119	4	by	by	ADP
cajgh-231	119	5	xiao	xiao	PROPN
cajgh-231	119	6	et	et	PROPN
cajgh-231	119	7	al.71	al.71	PROPN
cajgh-231	119	8	found	find	VERB
cajgh-231	119	9	hematologic	hematologic	NOUN
cajgh-231	119	10	abnormalities	abnormality	NOUN
cajgh-231	119	11	in	in	ADP
cajgh-231	119	12	alpha	alpha	NOUN
cajgh-231	119	13	-	-	PUNCT
cajgh-231	119	14	synuclein	synuclein	NOUN
cajgh-231	119	15	knock	knock	NOUN
cajgh-231	119	16	-	-	PUNCT
cajgh-231	119	17	out	out	ADP
cajgh-231	119	18	mice	mouse	NOUN
cajgh-231	119	19	indicative	indicative	ADJ
cajgh-231	119	20	of	of	ADP
cajgh-231	119	21	a	a	DET
cajgh-231	119	22	role	role	NOUN
cajgh-231	119	23	of	of	ADP
cajgh-231	119	24	alpha	alpha	NOUN
cajgh-231	119	25	-	-	PUNCT
cajgh-231	119	26	synuclein	synuclein	NOUN
cajgh-231	119	27	in	in	ADP
cajgh-231	119	28	late	late	ADJ
cajgh-231	119	29	-	-	PUNCT
cajgh-231	119	30	stage	stage	NOUN
cajgh-231	119	31	hematopoiesis	hematopoiesis	NOUN
cajgh-231	119	32	.	.	PUNCT
cajgh-231	120	1	a	a	DET
cajgh-231	120	2	genome	genome	NOUN
cajgh-231	120	3	-	-	PUNCT
cajgh-231	120	4	wide	wide	ADJ
cajgh-231	120	5	association	association	NOUN
cajgh-231	120	6	study	study	NOUN
cajgh-231	120	7	found	find	VERB
cajgh-231	120	8	that	that	SCONJ
cajgh-231	120	9	a	a	DET
cajgh-231	120	10	rare	rare	ADJ
cajgh-231	120	11	nonsynonymous	nonsynonymous	ADJ
cajgh-231	120	12	mutation	mutation	NOUN
cajgh-231	120	13	in	in	ADP
cajgh-231	120	14	dzip1	dzip1	PROPN
cajgh-231	120	15	is	be	AUX
cajgh-231	120	16	a	a	DET
cajgh-231	120	17	risk	risk	NOUN
cajgh-231	120	18	factor	factor	NOUN
cajgh-231	120	19	for	for	ADP
cajgh-231	120	20	pd.72	pd.72	ADJ
cajgh-231	120	21	dzip1	dzip1	NOUN
cajgh-231	120	22	is	be	AUX
cajgh-231	120	23	a	a	DET
cajgh-231	120	24	component	component	NOUN
cajgh-231	120	25	of	of	ADP
cajgh-231	120	26	the	the	DET
cajgh-231	120	27	hedgehog	hedgehog	NOUN
cajgh-231	120	28	signaling	signal	VERB
cajgh-231	120	29	pathway.73	pathway.73	NOUN
cajgh-231	120	30	besides	besides	SCONJ
cajgh-231	120	31	its	its	PRON
cajgh-231	120	32	role	role	NOUN
cajgh-231	120	33	in	in	ADP
cajgh-231	120	34	directing	direct	VERB
cajgh-231	120	35	embryonic	embryonic	ADJ
cajgh-231	120	36	pattern	pattern	NOUN
cajgh-231	120	37	formation	formation	NOUN
cajgh-231	120	38	,	,	PUNCT
cajgh-231	120	39	the	the	DET
cajgh-231	120	40	hedgehog	hedgehog	NOUN
cajgh-231	120	41	pathway	pathway	NOUN
cajgh-231	120	42	has	have	AUX
cajgh-231	120	43	been	be	AUX
cajgh-231	120	44	implicated	implicate	VERB
cajgh-231	120	45	in	in	ADP
cajgh-231	120	46	the	the	DET
cajgh-231	120	47	maintenance	maintenance	NOUN
cajgh-231	120	48	of	of	ADP
cajgh-231	120	49	adult	adult	NOUN
cajgh-231	120	50	stem	stem	NOUN
cajgh-231	120	51	cell	cell	NOUN
cajgh-231	120	52	niches	niche	NOUN
cajgh-231	120	53	,	,	PUNCT
cajgh-231	120	54	including	include	VERB
cajgh-231	120	55	both	both	CCONJ
cajgh-231	120	56	neuronal74	neuronal74	NOUN
cajgh-231	120	57	and	and	CCONJ
cajgh-231	120	58	hematopoietic	hematopoietic	ADJ
cajgh-231	120	59	stemcells.75	stemcells.75	PROPN
cajgh-231	120	60	finally	finally	ADV
cajgh-231	120	61	,	,	PUNCT
cajgh-231	120	62	pd	pd	PROPN
cajgh-231	120	63	patients	patient	NOUN
cajgh-231	120	64	are	be	AUX
cajgh-231	120	65	over	over	ADP
cajgh-231	120	66	five	five	NUM
cajgh-231	120	67	times	time	NOUN
cajgh-231	120	68	more	more	ADV
cajgh-231	120	69	likely	likely	ADJ
cajgh-231	120	70	to	to	PART
cajgh-231	120	71	be	be	AUX
cajgh-231	120	72	carriers	carrier	NOUN
cajgh-231	120	73	of	of	ADP
cajgh-231	120	74	the	the	DET
cajgh-231	120	75	mutated	mutate	VERB
cajgh-231	120	76	form	form	NOUN
cajgh-231	120	77	of	of	ADP
cajgh-231	120	78	gba	gba	PROPN
cajgh-231	120	79	responsible	responsible	ADJ
cajgh-231	120	80	for	for	ADP
cajgh-231	120	81	the	the	DET
cajgh-231	120	82	gaucher	gaucher	PROPN
cajgh-231	120	83	's	's	PART
cajgh-231	120	84	autosomal	autosomal	ADJ
cajgh-231	120	85	recessive	recessive	ADJ
cajgh-231	120	86	disease.76	disease.76	PROPN
cajgh-231	120	87	gaucher	gaucher	PROPN
cajgh-231	120	88	's	's	PART
cajgh-231	120	89	disease	disease	NOUN
cajgh-231	120	90	is	be	AUX
cajgh-231	120	91	characterized	characterize	VERB
cajgh-231	120	92	by	by	ADP
cajgh-231	120	93	low	low	ADJ
cajgh-231	120	94	blood	blood	NOUN
cajgh-231	120	95	platelet	platelet	NOUN
cajgh-231	120	96	levels	level	NOUN
cajgh-231	120	97	,	,	PUNCT
cajgh-231	120	98	anemia	anemia	NOUN
cajgh-231	120	99	,	,	PUNCT
cajgh-231	120	100	and	and	CCONJ
cajgh-231	120	101	the	the	DET
cajgh-231	120	102	accumulation	accumulation	NOUN
cajgh-231	120	103	of	of	ADP
cajgh-231	120	104	the	the	DET
cajgh-231	120	105	glycolipid	glycolipid	ADJ
cajgh-231	120	106	glucocerebroside	glucocerebroside	NOUN
cajgh-231	120	107	in	in	ADP
cajgh-231	120	108	the	the	DET
cajgh-231	120	109	mononuclear	mononuclear	ADJ
cajgh-231	120	110	phagocyte	phagocyte	NOUN
cajgh-231	120	111	system.77	system.77	NOUN
cajgh-231	120	112	in	in	ADP
cajgh-231	120	113	summary	summary	NOUN
cajgh-231	120	114	,	,	PUNCT
cajgh-231	120	115	we	we	PRON
cajgh-231	120	116	argued	argue	VERB
cajgh-231	120	117	for	for	ADP
cajgh-231	120	118	the	the	DET
cajgh-231	120	119	hematopoietic	hematopoietic	ADJ
cajgh-231	120	120	stem	stem	NOUN
cajgh-231	120	121	cell	cell	NOUN
cajgh-231	120	122	niche	niche	NOUN
cajgh-231	120	123	as	as	ADP
cajgh-231	120	124	a	a	DET
cajgh-231	120	125	possible	possible	ADJ
cajgh-231	120	126	site	site	NOUN
cajgh-231	120	127	for	for	ADP
cajgh-231	120	128	the	the	DET
cajgh-231	120	129	appearance	appearance	NOUN
cajgh-231	120	130	of	of	ADP
cajgh-231	120	131	a	a	DET
cajgh-231	120	132	primordial	primordial	ADJ
cajgh-231	120	133	pd	pd	ADJ
cajgh-231	120	134	-	-	PUNCT
cajgh-231	120	135	state	state	NOUN
cajgh-231	120	136	cell	cell	NOUN
cajgh-231	120	137	based	base	VERB
cajgh-231	120	138	on	on	ADP
cajgh-231	120	139	evidence	evidence	NOUN
cajgh-231	120	140	that	that	PRON
cajgh-231	120	141	supports	support	VERB
cajgh-231	120	142	:	:	PUNCT
cajgh-231	120	143	i	i	PRON
cajgh-231	120	144	)	)	PUNCT
cajgh-231	120	145	pd	pd	PROPN
cajgh-231	120	146	patients	patient	NOUN
cajgh-231	120	147	consistently	consistently	ADV
cajgh-231	120	148	having	have	VERB
cajgh-231	120	149	circulating	circulate	VERB
cajgh-231	120	150	hematopoietic	hematopoietic	ADJ
cajgh-231	120	151	cells	cell	NOUN
cajgh-231	120	152	in	in	ADP
cajgh-231	120	153	the	the	DET
cajgh-231	120	154	pd	pd	NOUN
cajgh-231	120	155	-	-	NOUN
cajgh-231	120	156	state	state	NOUN
cajgh-231	120	157	;	;	PUNCT
cajgh-231	120	158	ii	ii	X
cajgh-231	120	159	)	)	PUNCT
cajgh-231	120	160	those	those	DET
cajgh-231	120	161	hematopoietic	hematopoietic	ADJ
cajgh-231	120	162	cells	cell	NOUN
cajgh-231	120	163	more	more	ADV
cajgh-231	120	164	plausibly	plausibly	ADV
cajgh-231	120	165	having	having	AUX
cajgh-231	120	166	acquired	acquire	VERB
cajgh-231	120	167	the	the	DET
cajgh-231	120	168	pd	pd	NOUN
cajgh-231	120	169	-	-	NOUN
cajgh-231	120	170	state	state	NOUN
cajgh-231	120	171	at	at	ADP
cajgh-231	120	172	hematopoiesis	hematopoiesis	NOUN
cajgh-231	120	173	,	,	PUNCT
cajgh-231	120	174	rather	rather	ADV
cajgh-231	120	175	than	than	ADP
cajgh-231	120	176	after	after	ADP
cajgh-231	120	177	maturation	maturation	NOUN
cajgh-231	120	178	;	;	PUNCT
cajgh-231	120	179	and	and	CCONJ
cajgh-231	120	180	iii	iii	X
cajgh-231	120	181	)	)	PUNCT
cajgh-231	120	182	the	the	DET
cajgh-231	120	183	critical	critical	ADJ
cajgh-231	120	184	role	role	NOUN
cajgh-231	120	185	of	of	ADP
cajgh-231	120	186	ros	ros	PROPN
cajgh-231	120	187	in	in	ADP
cajgh-231	120	188	regulating	regulate	VERB
cajgh-231	120	189	the	the	DET
cajgh-231	120	190	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	120	191	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	120	192	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	120	193	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	120	194	valente	valente	NOUN
cajgh-231	120	195	this	this	DET
cajgh-231	120	196	work	work	NOUN
cajgh-231	120	197	is	be	AUX
cajgh-231	120	198	licensed	license	VERB
cajgh-231	120	199	under	under	ADP
cajgh-231	120	200	a	a	DET
cajgh-231	120	201	creative	creative	ADJ
cajgh-231	120	202	commons	common	NOUN
cajgh-231	120	203	attribution	attribution	NOUN
cajgh-231	120	204	4.0	4.0	NUM
cajgh-231	120	205	united	unite	VERB
cajgh-231	120	206	states	states	PROPN
cajgh-231	120	207	license	license	NOUN
cajgh-231	120	208	.	.	PUNCT
cajgh-231	121	1	this	this	DET
cajgh-231	121	2	journal	journal	NOUN
cajgh-231	121	3	is	be	AUX
cajgh-231	121	4	published	publish	VERB
cajgh-231	121	5	by	by	ADP
cajgh-231	121	6	theuniversity	theuniversity	NOUN
cajgh-231	121	7	library	library	NOUN
cajgh-231	121	8	system	system	NOUN
cajgh-231	121	9	of	of	ADP
cajgh-231	121	10	the	the	DET
cajgh-231	121	11	university	university	PROPN
cajgh-231	121	12	of	of	ADP
cajgh-231	121	13	pittsburgh	pittsburgh	PROPN
cajgh-231	121	14	as	as	ADP
cajgh-231	121	15	part	part	NOUN
cajgh-231	121	16	of	of	ADP
cajgh-231	121	17	its	its	PRON
cajgh-231	121	18	d	d	NOUN
cajgh-231	121	19	-	-	PUNCT
cajgh-231	121	20	scribe	scribe	VERB
cajgh-231	121	21	digital	digital	ADJ
cajgh-231	121	22	publishing	publishing	NOUN
cajgh-231	121	23	program	program	NOUN
cajgh-231	121	24	and	and	CCONJ
cajgh-231	121	25	is	be	AUX
cajgh-231	121	26	cosponsored	cosponsor	VERB
cajgh-231	121	27	by	by	ADP
cajgh-231	121	28	the	the	DET
cajgh-231	121	29	university	university	PROPN
cajgh-231	121	30	of	of	ADP
cajgh-231	121	31	pittsburgh	pittsburgh	PROPN
cajgh-231	121	32	press	press	NOUN
cajgh-231	121	33	.	.	PUNCT
cajgh-231	122	1	central	central	ADJ
cajgh-231	122	2	asian	asian	ADJ
cajgh-231	122	3	journal	journal	NOUN
cajgh-231	122	4	of	of	ADP
cajgh-231	122	5	global	global	ADJ
cajgh-231	122	6	health	health	NOUN
cajgh-231	122	7	volume	volume	NOUN
cajgh-231	122	8	4	4	NUM
cajgh-231	122	9	,	,	PUNCT
cajgh-231	122	10	no	no	INTJ
cajgh-231	122	11	.	.	NOUN
cajgh-231	122	12	1	1	NUM
cajgh-231	122	13	(	(	PUNCT
cajgh-231	122	14	2015	2015	NUM
cajgh-231	122	15	)	)	PUNCT
cajgh-231	122	16	|	|	ADV
cajgh-231	122	17	issn	issn	VERB
cajgh-231	122	18	2166	2166	NUM
cajgh-231	122	19	-	-	SYM
cajgh-231	122	20	7403	7403	NUM
cajgh-231	122	21	(	(	PUNCT
cajgh-231	122	22	online	online	ADJ
cajgh-231	122	23	)	)	PUNCT
cajgh-231	122	24	|	|	ADV
cajgh-231	122	25	doi	doi	X
cajgh-231	122	26	10.5195	10.5195	NUM
cajgh-231	122	27	/	/	SYM
cajgh-231	122	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	122	29	hematopoietic	hematopoietic	ADJ
cajgh-231	122	30	niche	niche	NOUN
cajgh-231	122	31	and	and	CCONJ
cajgh-231	122	32	the	the	DET
cajgh-231	122	33	disruption	disruption	NOUN
cajgh-231	122	34	of	of	ADP
cajgh-231	122	35	this	this	DET
cajgh-231	122	36	homeostasis	homeostasis	NOUN
cajgh-231	122	37	with	with	ADP
cajgh-231	122	38	ageing	ageing	NOUN
cajgh-231	122	39	.	.	PUNCT
cajgh-231	123	1	conclusion	conclusion	NOUN
cajgh-231	123	2	based	base	VERB
cajgh-231	123	3	on	on	ADP
cajgh-231	123	4	recently	recently	ADV
cajgh-231	123	5	published	publish	VERB
cajgh-231	123	6	findings	finding	NOUN
cajgh-231	123	7	that	that	PRON
cajgh-231	123	8	we	we	PRON
cajgh-231	123	9	considered	consider	VERB
cajgh-231	123	10	relevant	relevant	ADJ
cajgh-231	123	11	to	to	ADP
cajgh-231	123	12	the	the	DET
cajgh-231	123	13	pd	pd	PROPN
cajgh-231	123	14	field	field	NOUN
cajgh-231	123	15	,	,	PUNCT
cajgh-231	123	16	as	as	ADV
cajgh-231	123	17	well	well	ADV
cajgh-231	123	18	as	as	ADP
cajgh-231	123	19	on	on	ADP
cajgh-231	123	20	various	various	ADJ
cajgh-231	123	21	established	establish	VERB
cajgh-231	123	22	lines	line	NOUN
cajgh-231	123	23	of	of	ADP
cajgh-231	123	24	pd	pd	PROPN
cajgh-231	123	25	research	research	NOUN
cajgh-231	123	26	,	,	PUNCT
cajgh-231	123	27	we	we	PRON
cajgh-231	123	28	presented	present	VERB
cajgh-231	123	29	a	a	DET
cajgh-231	123	30	comprehensive	comprehensive	ADJ
cajgh-231	123	31	theory	theory	NOUN
cajgh-231	123	32	on	on	ADP
cajgh-231	123	33	the	the	DET
cajgh-231	123	34	nature	nature	NOUN
cajgh-231	123	35	,	,	PUNCT
cajgh-231	123	36	origin	origin	NOUN
cajgh-231	123	37	,	,	PUNCT
cajgh-231	123	38	and	and	CCONJ
cajgh-231	123	39	intercellular	intercellular	ADJ
cajgh-231	123	40	mode	mode	NOUN
cajgh-231	123	41	of	of	ADP
cajgh-231	123	42	propagation	propagation	NOUN
cajgh-231	123	43	of	of	ADP
cajgh-231	123	44	sporadic	sporadic	ADJ
cajgh-231	123	45	parkinson	parkinson	NOUN
cajgh-231	123	46	's	's	PART
cajgh-231	123	47	disease	disease	NOUN
cajgh-231	123	48	.	.	PUNCT
cajgh-231	124	1	we	we	PRON
cajgh-231	124	2	propose	propose	VERB
cajgh-231	124	3	to	to	PART
cajgh-231	124	4	define	define	VERB
cajgh-231	124	5	pd	pd	PROPN
cajgh-231	124	6	as	as	ADP
cajgh-231	124	7	a	a	DET
cajgh-231	124	8	characteristic	characteristic	ADJ
cajgh-231	124	9	pathological	pathological	ADJ
cajgh-231	124	10	deviation	deviation	NOUN
cajgh-231	124	11	in	in	ADP
cajgh-231	124	12	the	the	DET
cajgh-231	124	13	global	global	ADJ
cajgh-231	124	14	gene	gene	NOUN
cajgh-231	124	15	expression	expression	NOUN
cajgh-231	124	16	program	program	NOUN
cajgh-231	124	17	of	of	ADP
cajgh-231	124	18	a	a	DET
cajgh-231	124	19	cell	cell	NOUN
cajgh-231	124	20	:	:	PUNCT
cajgh-231	124	21	the	the	DET
cajgh-231	124	22	pd	pd	PROPN
cajgh-231	124	23	expression	expression	NOUN
cajgh-231	124	24	-	-	PUNCT
cajgh-231	124	25	state	state	NOUN
cajgh-231	124	26	,	,	PUNCT
cajgh-231	124	27	or	or	CCONJ
cajgh-231	124	28	pd	pd	NOUN
cajgh-231	124	29	-	-	NOUN
cajgh-231	124	30	state	state	NOUN
cajgh-231	124	31	for	for	ADP
cajgh-231	124	32	short	short	ADJ
cajgh-231	124	33	.	.	PUNCT
cajgh-231	125	1	most	most	ADV
cajgh-231	125	2	significantly	significantly	ADV
cajgh-231	125	3	,	,	PUNCT
cajgh-231	125	4	we	we	PRON
cajgh-231	125	5	argue	argue	VERB
cajgh-231	125	6	that	that	SCONJ
cajgh-231	125	7	any	any	DET
cajgh-231	125	8	cell	cell	NOUN
cajgh-231	125	9	could	could	AUX
cajgh-231	125	10	be	be	AUX
cajgh-231	125	11	in	in	ADP
cajgh-231	125	12	the	the	DET
cajgh-231	125	13	pd	pd	NOUN
cajgh-231	125	14	-	-	NOUN
cajgh-231	125	15	state	state	NOUN
cajgh-231	125	16	.	.	PUNCT
cajgh-231	126	1	however	however	ADV
cajgh-231	126	2	,	,	PUNCT
cajgh-231	126	3	due	due	ADP
cajgh-231	126	4	to	to	ADP
cajgh-231	126	5	the	the	DET
cajgh-231	126	6	cell	cell	NOUN
cajgh-231	126	7	processes	process	NOUN
cajgh-231	126	8	it	it	PRON
cajgh-231	126	9	affects	affect	VERB
cajgh-231	126	10	the	the	DET
cajgh-231	126	11	most	most	ADJ
cajgh-231	126	12	,	,	PUNCT
cajgh-231	126	13	the	the	DET
cajgh-231	126	14	pd	pd	ADJ
cajgh-231	126	15	-	-	PUNCT
cajgh-231	126	16	state	state	NOUN
cajgh-231	126	17	deviation	deviation	NOUN
cajgh-231	126	18	would	would	AUX
cajgh-231	126	19	be	be	AUX
cajgh-231	126	20	particularly	particularly	ADV
cajgh-231	126	21	damaging	damaging	ADJ
cajgh-231	126	22	to	to	ADP
cajgh-231	126	23	neurons	neuron	NOUN
cajgh-231	126	24	,	,	PUNCT
cajgh-231	126	25	ultimately	ultimately	ADV
cajgh-231	126	26	leading	lead	VERB
cajgh-231	126	27	to	to	ADP
cajgh-231	126	28	neuron	neuron	VERB
cajgh-231	126	29	death	death	NOUN
cajgh-231	126	30	and	and	CCONJ
cajgh-231	126	31	the	the	DET
cajgh-231	126	32	clinical	clinical	ADJ
cajgh-231	126	33	manifestations	manifestation	NOUN
cajgh-231	126	34	of	of	ADP
cajgh-231	126	35	pd	pd	PROPN
cajgh-231	126	36	.	.	PUNCT
cajgh-231	126	37	ageing	age	VERB
cajgh-231	126	38	-	-	PUNCT
cajgh-231	126	39	associated	associate	VERB
cajgh-231	126	40	accumulated	accumulate	VERB
cajgh-231	126	41	damage	damage	NOUN
cajgh-231	126	42	caused	cause	VERB
cajgh-231	126	43	by	by	ADP
cajgh-231	126	44	oxidative	oxidative	ADJ
cajgh-231	126	45	stress	stress	NOUN
cajgh-231	126	46	in	in	ADP
cajgh-231	126	47	mitochondria	mitochondria	NOUN
cajgh-231	126	48	could	could	AUX
cajgh-231	126	49	be	be	AUX
cajgh-231	126	50	the	the	DET
cajgh-231	126	51	trigger	trigger	NOUN
cajgh-231	126	52	for	for	SCONJ
cajgh-231	126	53	a	a	DET
cajgh-231	126	54	primordial	primordial	ADJ
cajgh-231	126	55	cell	cell	NOUN
cajgh-231	126	56	to	to	PART
cajgh-231	126	57	shift	shift	VERB
cajgh-231	126	58	to	to	ADP
cajgh-231	126	59	the	the	DET
cajgh-231	126	60	pd	pd	NOUN
cajgh-231	126	61	-	-	NOUN
cajgh-231	126	62	state	state	NOUN
cajgh-231	126	63	.	.	PUNCT
cajgh-231	127	1	in	in	ADP
cajgh-231	127	2	particular	particular	ADJ
cajgh-231	127	3	,	,	PUNCT
cajgh-231	127	4	hematopoietic	hematopoietic	ADJ
cajgh-231	127	5	cells	cell	NOUN
cajgh-231	127	6	could	could	AUX
cajgh-231	127	7	be	be	AUX
cajgh-231	127	8	the	the	DET
cajgh-231	127	9	first	first	ADJ
cajgh-231	127	10	to	to	PART
cajgh-231	127	11	acquire	acquire	VERB
cajgh-231	127	12	the	the	DET
cajgh-231	127	13	pd	pd	NOUN
cajgh-231	127	14	-	-	NOUN
cajgh-231	127	15	state	state	NOUN
cajgh-231	127	16	,	,	PUNCT
cajgh-231	127	17	at	at	ADP
cajgh-231	127	18	hematopoiesis	hematopoiesis	NOUN
cajgh-231	127	19	,	,	PUNCT
cajgh-231	127	20	as	as	ADP
cajgh-231	127	21	a	a	DET
cajgh-231	127	22	result	result	NOUN
cajgh-231	127	23	of	of	ADP
cajgh-231	127	24	the	the	DET
cajgh-231	127	25	disruption	disruption	NOUN
cajgh-231	127	26	in	in	ADP
cajgh-231	127	27	ros	ros	PROPN
cajgh-231	127	28	homeostasis	homeostasis	NOUN
cajgh-231	127	29	that	that	PRON
cajgh-231	127	30	arises	arise	VERB
cajgh-231	127	31	with	with	ADP
cajgh-231	127	32	age	age	NOUN
cajgh-231	127	33	in	in	ADP
cajgh-231	127	34	the	the	DET
cajgh-231	127	35	hematopoietic	hematopoietic	ADJ
cajgh-231	127	36	stem	stem	NOUN
cajgh-231	127	37	-	-	PUNCT
cajgh-231	127	38	cell	cell	NOUN
cajgh-231	127	39	niche	niche	NOUN
cajgh-231	127	40	.	.	PUNCT
cajgh-231	128	1	the	the	DET
cajgh-231	128	2	small	small	ADJ
cajgh-231	128	3	correlation	correlation	NOUN
cajgh-231	128	4	of	of	ADP
cajgh-231	128	5	pd	pd	NOUN
cajgh-231	128	6	incidence	incidence	NOUN
cajgh-231	128	7	with	with	ADP
cajgh-231	128	8	genetic	genetic	ADJ
cajgh-231	128	9	and	and	CCONJ
cajgh-231	128	10	environmental	environmental	ADJ
cajgh-231	128	11	factors	factor	NOUN
cajgh-231	128	12	would	would	AUX
cajgh-231	128	13	mostly	mostly	ADV
cajgh-231	128	14	follow	follow	VERB
cajgh-231	128	15	from	from	ADP
cajgh-231	128	16	this	this	DET
cajgh-231	128	17	pd	pd	PROPN
cajgh-231	128	18	initiation	initiation	NOUN
cajgh-231	128	19	dynamics	dynamic	NOUN
cajgh-231	128	20	.	.	PUNCT
cajgh-231	129	1	propagation	propagation	NOUN
cajgh-231	129	2	of	of	ADP
cajgh-231	129	3	the	the	DET
cajgh-231	129	4	pd	pd	NOUN
cajgh-231	129	5	-	-	NOUN
cajgh-231	129	6	state	state	NOUN
cajgh-231	129	7	across	across	ADP
cajgh-231	129	8	the	the	DET
cajgh-231	129	9	organism	organism	NOUN
cajgh-231	129	10	would	would	AUX
cajgh-231	129	11	occur	occur	VERB
cajgh-231	129	12	in	in	ADP
cajgh-231	129	13	a	a	DET
cajgh-231	129	14	second	second	ADJ
cajgh-231	129	15	phase	phase	NOUN
cajgh-231	129	16	and	and	CCONJ
cajgh-231	129	17	via	via	ADP
cajgh-231	129	18	a	a	DET
cajgh-231	129	19	distinct	distinct	ADJ
cajgh-231	129	20	mechanism	mechanism	NOUN
cajgh-231	129	21	.	.	PUNCT
cajgh-231	130	1	we	we	PRON
cajgh-231	130	2	proposed	propose	VERB
cajgh-231	130	3	that	that	SCONJ
cajgh-231	130	4	the	the	DET
cajgh-231	130	5	ability	ability	NOUN
cajgh-231	130	6	of	of	ADP
cajgh-231	130	7	mtdna	mtdna	NOUN
cajgh-231	130	8	to	to	PART
cajgh-231	130	9	move	move	VERB
cajgh-231	130	10	across	across	ADP
cajgh-231	130	11	cells	cell	NOUN
cajgh-231	130	12	and	and	CCONJ
cajgh-231	130	13	to	to	PART
cajgh-231	130	14	modulate	modulate	VERB
cajgh-231	130	15	the	the	DET
cajgh-231	130	16	cellular	cellular	ADJ
cajgh-231	130	17	global	global	ADJ
cajgh-231	130	18	gene	gene	NOUN
cajgh-231	130	19	expression	expression	NOUN
cajgh-231	130	20	state	state	NOUN
cajgh-231	130	21	could	could	AUX
cajgh-231	130	22	form	form	VERB
cajgh-231	130	23	the	the	DET
cajgh-231	130	24	basis	basis	NOUN
cajgh-231	130	25	for	for	ADP
cajgh-231	130	26	this	this	DET
cajgh-231	130	27	inter	inter	ADJ
cajgh-231	130	28	-	-	ADJ
cajgh-231	130	29	cellular	cellular	ADJ
cajgh-231	130	30	propagation	propagation	NOUN
cajgh-231	130	31	of	of	ADP
cajgh-231	130	32	the	the	DET
cajgh-231	130	33	pd	pd	NOUN
cajgh-231	130	34	-	-	NOUN
cajgh-231	130	35	state	state	NOUN
cajgh-231	130	36	.	.	PUNCT
cajgh-231	131	1	the	the	DET
cajgh-231	131	2	mtdna	mtdna	NOUN
cajgh-231	131	3	-	-	PUNCT
cajgh-231	131	4	based	base	VERB
cajgh-231	131	5	pd	pd	PROPN
cajgh-231	131	6	propagation	propagation	NOUN
cajgh-231	131	7	dynamics	dynamic	NOUN
cajgh-231	131	8	would	would	AUX
cajgh-231	131	9	occur	occur	VERB
cajgh-231	131	10	on	on	ADP
cajgh-231	131	11	a	a	DET
cajgh-231	131	12	time	time	NOUN
cajgh-231	131	13	-	-	PUNCT
cajgh-231	131	14	scale	scale	NOUN
cajgh-231	131	15	of	of	ADP
cajgh-231	131	16	years	year	NOUN
cajgh-231	131	17	,	,	PUNCT
cajgh-231	131	18	as	as	SCONJ
cajgh-231	131	19	observed	observe	VERB
cajgh-231	131	20	in	in	ADP
cajgh-231	131	21	patients	patient	NOUN
cajgh-231	131	22	,	,	PUNCT
cajgh-231	131	23	and	and	CCONJ
cajgh-231	131	24	not	not	PART
cajgh-231	131	25	be	be	AUX
cajgh-231	131	26	ageing	age	VERB
cajgh-231	131	27	-	-	PUNCT
cajgh-231	131	28	dependent	dependent	ADJ
cajgh-231	131	29	,	,	PUNCT
cajgh-231	131	30	in	in	ADP
cajgh-231	131	31	contrast	contrast	NOUN
cajgh-231	131	32	with	with	ADP
cajgh-231	131	33	the	the	DET
cajgh-231	131	34	pd	pd	PROPN
cajgh-231	131	35	initiation	initiation	NOUN
cajgh-231	131	36	dynamics	dynamic	NOUN
cajgh-231	131	37	.	.	PUNCT
cajgh-231	132	1	under	under	ADP
cajgh-231	132	2	physiological	physiological	ADJ
cajgh-231	132	3	conditions	condition	NOUN
cajgh-231	132	4	,	,	PUNCT
cajgh-231	132	5	mice	mouse	NOUN
cajgh-231	132	6	are	be	AUX
cajgh-231	132	7	not	not	PART
cajgh-231	132	8	susceptible	susceptible	ADJ
cajgh-231	132	9	to	to	ADP
cajgh-231	132	10	pd	pd	PROPN
cajgh-231	132	11	late	late	ADV
cajgh-231	132	12	in	in	ADP
cajgh-231	132	13	life	life	NOUN
cajgh-231	132	14	,	,	PUNCT
cajgh-231	132	15	in	in	ADP
cajgh-231	132	16	spite	spite	NOUN
cajgh-231	132	17	of	of	ADP
cajgh-231	132	18	clearly	clearly	ADV
cajgh-231	132	19	showing	show	VERB
cajgh-231	132	20	an	an	DET
cajgh-231	132	21	ageing	age	VERB
cajgh-231	132	22	phenotype	phenotype	NOUN
cajgh-231	132	23	just	just	ADV
cajgh-231	132	24	as	as	SCONJ
cajgh-231	132	25	humans	human	NOUN
cajgh-231	132	26	do.78	do.78	VERB
cajgh-231	132	27	this	this	DET
cajgh-231	132	28	absence	absence	NOUN
cajgh-231	132	29	of	of	ADP
cajgh-231	132	30	a	a	DET
cajgh-231	132	31	pd	pd	NOUN
cajgh-231	132	32	phenotype	phenotype	NOUN
cajgh-231	132	33	in	in	ADP
cajgh-231	132	34	mice	mouse	NOUN
cajgh-231	132	35	could	could	AUX
cajgh-231	132	36	thus	thus	ADV
cajgh-231	132	37	more	more	ADV
cajgh-231	132	38	likely	likely	ADJ
cajgh-231	132	39	follow	follow	VERB
cajgh-231	132	40	from	from	ADP
cajgh-231	132	41	the	the	DET
cajgh-231	132	42	ageing	age	VERB
cajgh-231	132	43	-	-	PUNCT
cajgh-231	132	44	independent	independent	ADJ
cajgh-231	132	45	pd	pd	NOUN
cajgh-231	132	46	spread	spread	NOUN
cajgh-231	132	47	dynamics	dynamic	NOUN
cajgh-231	132	48	,	,	PUNCT
cajgh-231	132	49	than	than	ADP
cajgh-231	132	50	from	from	ADP
cajgh-231	132	51	the	the	DET
cajgh-231	132	52	ageing	age	VERB
cajgh-231	132	53	-	-	PUNCT
cajgh-231	132	54	associated	associate	VERB
cajgh-231	132	55	pd	pd	PROPN
cajgh-231	132	56	initiation	initiation	NOUN
cajgh-231	132	57	dynamics	dynamic	NOUN
cajgh-231	132	58	.	.	PUNCT
cajgh-231	133	1	namely	namely	ADV
cajgh-231	133	2	,	,	PUNCT
cajgh-231	133	3	going	go	VERB
cajgh-231	133	4	from	from	ADP
cajgh-231	133	5	human	human	NOUN
cajgh-231	133	6	to	to	ADP
cajgh-231	133	7	mouse	mouse	PROPN
cajgh-231	133	8	,	,	PUNCT
cajgh-231	133	9	the	the	DET
cajgh-231	133	10	mtdna	mtdna	NOUN
cajgh-231	133	11	propagation	propagation	NOUN
cajgh-231	133	12	dynamics	dynamic	NOUN
cajgh-231	133	13	would	would	AUX
cajgh-231	133	14	not	not	PART
cajgh-231	133	15	scale	scale	VERB
cajgh-231	133	16	appropriately	appropriately	ADV
cajgh-231	133	17	time	time	NOUN
cajgh-231	133	18	-	-	PUNCT
cajgh-231	133	19	wise	wise	ADJ
cajgh-231	133	20	to	to	PART
cajgh-231	133	21	permit	permit	VERB
cajgh-231	133	22	the	the	DET
cajgh-231	133	23	condition	condition	NOUN
cajgh-231	133	24	to	to	PART
cajgh-231	133	25	reach	reach	VERB
cajgh-231	133	26	the	the	DET
cajgh-231	133	27	neuronal	neuronal	ADJ
cajgh-231	133	28	system	system	NOUN
cajgh-231	133	29	in	in	ADP
cajgh-231	133	30	the	the	DET
cajgh-231	133	31	lifetime	lifetime	NOUN
cajgh-231	133	32	of	of	ADP
cajgh-231	133	33	a	a	DET
cajgh-231	133	34	mouse	mouse	NOUN
cajgh-231	133	35	.	.	PUNCT
cajgh-231	134	1	early	early	ADJ
cajgh-231	134	2	symptoms	symptom	NOUN
cajgh-231	134	3	of	of	ADP
cajgh-231	134	4	pd	pd	PROPN
cajgh-231	134	5	in	in	ADP
cajgh-231	134	6	humans	human	NOUN
cajgh-231	134	7	include	include	VERB
cajgh-231	134	8	impaired	impaired	ADJ
cajgh-231	134	9	sense	sense	NOUN
cajgh-231	134	10	of	of	ADP
cajgh-231	134	11	smell10	smell10	NOUN
cajgh-231	134	12	and	and	CCONJ
cajgh-231	134	13	gastrointestinal	gastrointestinal	ADJ
cajgh-231	134	14	dysfunction.79	dysfunction.79	NOUN
cajgh-231	134	15	both	both	PRON
cajgh-231	134	16	have	have	AUX
cajgh-231	134	17	been	be	AUX
cajgh-231	134	18	reported	report	VERB
cajgh-231	134	19	as	as	ADV
cajgh-231	134	20	much	much	ADV
cajgh-231	134	21	as	as	ADP
cajgh-231	134	22	a	a	DET
cajgh-231	134	23	decade	decade	NOUN
cajgh-231	134	24	before	before	ADP
cajgh-231	134	25	the	the	DET
cajgh-231	134	26	appearance	appearance	NOUN
cajgh-231	134	27	of	of	ADP
cajgh-231	134	28	symptoms	symptom	NOUN
cajgh-231	134	29	at	at	ADP
cajgh-231	134	30	the	the	DET
cajgh-231	134	31	motor	motor	NOUN
cajgh-231	134	32	level	level	NOUN
cajgh-231	134	33	.	.	PUNCT
cajgh-231	135	1	they	they	PRON
cajgh-231	135	2	are	be	AUX
cajgh-231	135	3	typically	typically	ADV
cajgh-231	135	4	interpreted	interpret	VERB
cajgh-231	135	5	as	as	ADP
cajgh-231	135	6	supporting	support	VERB
cajgh-231	135	7	the	the	DET
cajgh-231	135	8	role	role	NOUN
cajgh-231	135	9	of	of	ADP
cajgh-231	135	10	an	an	DET
cajgh-231	135	11	external	external	ADJ
cajgh-231	135	12	agent	agent	NOUN
cajgh-231	135	13	entering	enter	VERB
cajgh-231	135	14	via	via	ADP
cajgh-231	135	15	the	the	DET
cajgh-231	135	16	olfactory	olfactory	NOUN
cajgh-231	135	17	or	or	CCONJ
cajgh-231	135	18	gastro	gastro	ADJ
cajgh-231	135	19	-	-	PUNCT
cajgh-231	135	20	intestinal	intestinal	ADJ
cajgh-231	135	21	entry	entry	NOUN
cajgh-231	135	22	points	point	NOUN
cajgh-231	135	23	in	in	ADP
cajgh-231	135	24	inducting	induct	VERB
cajgh-231	135	25	pd.12	pd.12	NOUN
cajgh-231	135	26	however	however	ADV
cajgh-231	135	27	,	,	PUNCT
cajgh-231	135	28	another	another	DET
cajgh-231	135	29	characteristic	characteristic	NOUN
cajgh-231	135	30	shared	share	VERB
cajgh-231	135	31	by	by	ADP
cajgh-231	135	32	the	the	DET
cajgh-231	135	33	olfactory	olfactory	NOUN
cajgh-231	135	34	bulb	bulb	NOUN
cajgh-231	135	35	and	and	CCONJ
cajgh-231	135	36	the	the	DET
cajgh-231	135	37	gastro	gastro	ADJ
cajgh-231	135	38	-	-	PUNCT
cajgh-231	135	39	intestinal	intestinal	ADJ
cajgh-231	135	40	tract	tract	NOUN
cajgh-231	135	41	is	be	AUX
cajgh-231	135	42	that	that	SCONJ
cajgh-231	135	43	they	they	PRON
cajgh-231	135	44	are	be	AUX
cajgh-231	135	45	both	both	PRON
cajgh-231	135	46	sites	site	NOUN
cajgh-231	135	47	of	of	ADP
cajgh-231	135	48	very	very	ADV
cajgh-231	135	49	active	active	ADJ
cajgh-231	135	50	stem	stem	NOUN
cajgh-231	135	51	-	-	PUNCT
cajgh-231	135	52	cell	cell	NOUN
cajgh-231	135	53	based	base	VERB
cajgh-231	135	54	tissue	tissue	NOUN
cajgh-231	135	55	regeneration.80,81	regeneration.80,81	VERB
cajgh-231	135	56	the	the	DET
cajgh-231	135	57	rapid	rapid	ADJ
cajgh-231	135	58	cell	cell	NOUN
cajgh-231	135	59	renewal	renewal	NOUN
cajgh-231	135	60	and	and	CCONJ
cajgh-231	135	61	the	the	DET
cajgh-231	135	62	plasticity	plasticity	NOUN
cajgh-231	135	63	of	of	ADP
cajgh-231	135	64	immature	immature	ADJ
cajgh-231	135	65	cells	cell	NOUN
cajgh-231	135	66	could	could	AUX
cajgh-231	135	67	facilitate	facilitate	VERB
cajgh-231	135	68	both	both	CCONJ
cajgh-231	135	69	the	the	DET
cajgh-231	135	70	cellular	cellular	ADJ
cajgh-231	135	71	uptake	uptake	NOUN
cajgh-231	135	72	of	of	ADP
cajgh-231	135	73	carriers	carrier	NOUN
cajgh-231	135	74	of	of	ADP
cajgh-231	135	75	external	external	ADJ
cajgh-231	135	76	mtdna	mtdna	NOUN
cajgh-231	135	77	and	and	CCONJ
cajgh-231	135	78	the	the	DET
cajgh-231	135	79	global	global	ADJ
cajgh-231	135	80	cellular	cellular	ADJ
cajgh-231	135	81	reprogramming	reprogramme	VERB
cajgh-231	135	82	to	to	ADP
cajgh-231	135	83	the	the	DET
cajgh-231	135	84	pd	pd	NOUN
cajgh-231	135	85	-	-	NOUN
cajgh-231	135	86	state	state	NOUN
cajgh-231	135	87	,	,	PUNCT
cajgh-231	135	88	explaining	explain	VERB
cajgh-231	135	89	the	the	DET
cajgh-231	135	90	olfactory	olfactory	NOUN
cajgh-231	135	91	bulb	bulb	NOUN
cajgh-231	135	92	and	and	CCONJ
cajgh-231	135	93	the	the	DET
cajgh-231	135	94	gastro	gastro	ADJ
cajgh-231	135	95	-	-	PUNCT
cajgh-231	135	96	intestinal	intestinal	ADJ
cajgh-231	135	97	tract	tract	NOUN
cajgh-231	135	98	being	be	AUX
cajgh-231	135	99	some	some	PRON
cajgh-231	135	100	of	of	ADP
cajgh-231	135	101	the	the	DET
cajgh-231	135	102	earlier	early	ADJ
cajgh-231	135	103	sites	site	NOUN
cajgh-231	135	104	to	to	PART
cajgh-231	135	105	which	which	PRON
cajgh-231	135	106	the	the	DET
cajgh-231	135	107	pdstate	pdstate	NOUN
cajgh-231	135	108	would	would	AUX
cajgh-231	135	109	spread	spread	VERB
cajgh-231	135	110	.	.	PUNCT
cajgh-231	136	1	finally	finally	ADV
cajgh-231	136	2	,	,	PUNCT
cajgh-231	136	3	although	although	SCONJ
cajgh-231	136	4	our	our	PRON
cajgh-231	136	5	theory	theory	NOUN
cajgh-231	136	6	was	be	AUX
cajgh-231	136	7	presented	present	VERB
cajgh-231	136	8	in	in	ADP
cajgh-231	136	9	the	the	DET
cajgh-231	136	10	context	context	NOUN
cajgh-231	136	11	of	of	ADP
cajgh-231	136	12	pd	pd	PROPN
cajgh-231	136	13	,	,	PUNCT
cajgh-231	136	14	we	we	PRON
cajgh-231	136	15	note	note	VERB
cajgh-231	136	16	its	its	PRON
cajgh-231	136	17	general	general	ADJ
cajgh-231	136	18	potential	potential	ADJ
cajgh-231	136	19	relevance	relevance	NOUN
cajgh-231	136	20	to	to	ADP
cajgh-231	136	21	other	other	ADJ
cajgh-231	136	22	pathologies	pathology	NOUN
cajgh-231	136	23	where	where	SCONJ
cajgh-231	136	24	systemic	systemic	ADJ
cajgh-231	136	25	bioenergetic	bioenergetic	ADJ
cajgh-231	136	26	cellular	cellular	ADJ
cajgh-231	136	27	deficiency	deficiency	NOUN
cajgh-231	136	28	is	be	AUX
cajgh-231	136	29	a	a	DET
cajgh-231	136	30	prominent	prominent	ADJ
cajgh-231	136	31	feature	feature	NOUN
cajgh-231	136	32	.	.	PUNCT
cajgh-231	137	1	acknowledgements	acknowledgement	NOUN
cajgh-231	137	2	the	the	DET
cajgh-231	137	3	authors	author	NOUN
cajgh-231	137	4	would	would	AUX
cajgh-231	137	5	like	like	VERB
cajgh-231	137	6	to	to	PART
cajgh-231	137	7	thank	thank	VERB
cajgh-231	137	8	the	the	DET
cajgh-231	137	9	montepio	montepio	ADJ
cajgh-231	137	10	foundation	foundation	NOUN
cajgh-231	137	11	for	for	ADP
cajgh-231	137	12	financial	financial	ADJ
cajgh-231	137	13	support	support	NOUN
cajgh-231	137	14	;	;	PUNCT
cajgh-231	137	15	the	the	DET
cajgh-231	137	16	center	center	NOUN
cajgh-231	137	17	for	for	ADP
cajgh-231	137	18	neuroscience	neuroscience	NOUN
cajgh-231	137	19	and	and	CCONJ
cajgh-231	137	20	cell	cell	NOUN
cajgh-231	137	21	biology	biology	NOUN
cajgh-231	137	22	(	(	PUNCT
cajgh-231	137	23	project	project	NOUN
cajgh-231	137	24	pestc	pestc	NOUN
cajgh-231	137	25	/	/	SYM
cajgh-231	137	26	sau	sau	PROPN
cajgh-231	137	27	/	/	SYM
cajgh-231	137	28	la0001/2013	la0001/2013	NOUN
cajgh-231	137	29	-	-	PUNCT
cajgh-231	137	30	2014	2014	NUM
cajgh-231	137	31	)	)	PUNCT
cajgh-231	137	32	;	;	PUNCT
cajgh-231	137	33	the	the	DET
cajgh-231	137	34	portuguese	portuguese	ADJ
cajgh-231	137	35	national	national	ADJ
cajgh-231	137	36	funds	fund	NOUN
cajgh-231	137	37	via	via	ADP
cajgh-231	137	38	the	the	DET
cajgh-231	137	39	programs	program	NOUN
cajgh-231	137	40	feder	feder	NOUN
cajgh-231	137	41	and	and	CCONJ
cajgh-231	137	42	compete	compete	VERB
cajgh-231	137	43	;	;	PUNCT
cajgh-231	137	44	the	the	DET
cajgh-231	137	45	fundação	fundação	NOUN
cajgh-231	137	46	para	para	NOUN
cajgh-231	137	47	a	a	DET
cajgh-231	137	48	ciência	ciência	PROPN
cajgh-231	137	49	e	e	NOUN
cajgh-231	137	50	tecnologia	tecnologia	NOUN
cajgh-231	137	51	;	;	PUNCT
cajgh-231	137	52	the	the	DET
cajgh-231	137	53	program	program	NOUN
cajgh-231	137	54	of	of	ADP
cajgh-231	137	55	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	137	56	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	137	57	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	X
cajgh-231	137	58	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	137	59	central	central	ADJ
cajgh-231	137	60	asian	asian	ADJ
cajgh-231	137	61	journal	journal	NOUN
cajgh-231	137	62	of	of	ADP
cajgh-231	137	63	global	global	ADJ
cajgh-231	137	64	health	health	NOUN
cajgh-231	137	65	this	this	DET
cajgh-231	137	66	work	work	NOUN
cajgh-231	137	67	is	be	AUX
cajgh-231	137	68	licensed	license	VERB
cajgh-231	137	69	under	under	ADP
cajgh-231	137	70	a	a	DET
cajgh-231	137	71	creative	creative	ADJ
cajgh-231	137	72	commons	common	NOUN
cajgh-231	137	73	attribution	attribution	NOUN
cajgh-231	137	74	4.0	4.0	NUM
cajgh-231	137	75	united	unite	VERB
cajgh-231	137	76	states	states	PROPN
cajgh-231	137	77	license	license	NOUN
cajgh-231	137	78	.	.	PUNCT
cajgh-231	138	1	this	this	DET
cajgh-231	138	2	journal	journal	NOUN
cajgh-231	138	3	is	be	AUX
cajgh-231	138	4	published	publish	VERB
cajgh-231	138	5	by	by	ADP
cajgh-231	138	6	theuniversity	theuniversity	NOUN
cajgh-231	138	7	library	library	NOUN
cajgh-231	138	8	system	system	NOUN
cajgh-231	138	9	of	of	ADP
cajgh-231	138	10	the	the	DET
cajgh-231	138	11	university	university	PROPN
cajgh-231	138	12	of	of	ADP
cajgh-231	138	13	pittsburgh	pittsburgh	PROPN
cajgh-231	138	14	as	as	ADP
cajgh-231	138	15	part	part	NOUN
cajgh-231	138	16	of	of	ADP
cajgh-231	138	17	its	its	PRON
cajgh-231	138	18	d	d	NOUN
cajgh-231	138	19	-	-	PUNCT
cajgh-231	138	20	scribe	scribe	VERB
cajgh-231	138	21	digital	digital	ADJ
cajgh-231	138	22	publishing	publishing	NOUN
cajgh-231	138	23	program	program	NOUN
cajgh-231	138	24	and	and	CCONJ
cajgh-231	138	25	is	be	AUX
cajgh-231	138	26	cosponsored	cosponsor	VERB
cajgh-231	138	27	by	by	ADP
cajgh-231	138	28	the	the	DET
cajgh-231	138	29	university	university	PROPN
cajgh-231	138	30	of	of	ADP
cajgh-231	138	31	pittsburgh	pittsburgh	PROPN
cajgh-231	138	32	press	press	NOUN
cajgh-231	138	33	.	.	PUNCT
cajgh-231	139	1	central	central	ADJ
cajgh-231	139	2	asian	asian	ADJ
cajgh-231	139	3	journal	journal	NOUN
cajgh-231	139	4	of	of	ADP
cajgh-231	139	5	global	global	ADJ
cajgh-231	139	6	health	health	NOUN
cajgh-231	139	7	volume	volume	NOUN
cajgh-231	139	8	4	4	NUM
cajgh-231	139	9	,	,	PUNCT
cajgh-231	139	10	no	no	INTJ
cajgh-231	139	11	.	.	NOUN
cajgh-231	139	12	1	1	NUM
cajgh-231	139	13	(	(	PUNCT
cajgh-231	139	14	2015	2015	NUM
cajgh-231	139	15	)	)	PUNCT
cajgh-231	139	16	|	|	ADV
cajgh-231	139	17	issn	issn	VERB
cajgh-231	139	18	2166	2166	NUM
cajgh-231	139	19	-	-	SYM
cajgh-231	139	20	7403	7403	NUM
cajgh-231	139	21	(	(	PUNCT
cajgh-231	139	22	online	online	ADJ
cajgh-231	139	23	)	)	PUNCT
cajgh-231	139	24	|	|	ADV
cajgh-231	139	25	doi	doi	X
cajgh-231	139	26	10.5195	10.5195	NUM
cajgh-231	139	27	/	/	SYM
cajgh-231	139	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	VERB
cajgh-231	139	29	competitive	competitive	ADJ
cajgh-231	139	30	growth	growth	NOUN
cajgh-231	139	31	of	of	ADP
cajgh-231	139	32	kazan	kazan	PROPN
cajgh-231	139	33	federal	federal	PROPN
cajgh-231	139	34	university	university	PROPN
cajgh-231	139	35	;	;	PUNCT
cajgh-231	139	36	a	a	DET
cajgh-231	139	37	subsidy	subsidy	NOUN
cajgh-231	139	38	to	to	ADP
cajgh-231	139	39	kazan	kazan	PROPN
cajgh-231	139	40	federal	federal	PROPN
cajgh-231	139	41	university	university	PROPN
cajgh-231	139	42	for	for	ADP
cajgh-231	139	43	the	the	DET
cajgh-231	139	44	state	state	NOUN
cajgh-231	139	45	assignment	assignment	NOUN
cajgh-231	139	46	in	in	ADP
cajgh-231	139	47	the	the	DET
cajgh-231	139	48	area	area	NOUN
cajgh-231	139	49	of	of	ADP
cajgh-231	139	50	scientific	scientific	ADJ
cajgh-231	139	51	activities	activity	NOUN
cajgh-231	139	52	.	.	PUNCT
cajgh-231	140	1	references	reference	NOUN
cajgh-231	140	2	1	1	NUM
cajgh-231	140	3	.	.	PUNCT
cajgh-231	141	1	statistics	statistic	NOUN
cajgh-231	141	2	on	on	ADP
cajgh-231	141	3	parkinson	parkinson	NOUN
cajgh-231	141	4	's	's	PART
cajgh-231	141	5	.	.	PUNCT
cajgh-231	142	1	2	2	X
cajgh-231	142	2	.	.	X
cajgh-231	142	3	shrestha	shrestha	PROPN
cajgh-231	143	1	lb	lb	PROPN
cajgh-231	143	2	.	.	PUNCT
cajgh-231	143	3	population	population	NOUN
cajgh-231	143	4	aging	age	VERB
cajgh-231	143	5	in	in	ADP
cajgh-231	143	6	developing	develop	VERB
cajgh-231	143	7	countries	country	NOUN
cajgh-231	143	8	.	.	PUNCT
cajgh-231	144	1	health	health	PROPN
cajgh-231	144	2	aff	aff	PROPN
cajgh-231	144	3	.	.	PUNCT
cajgh-231	145	1	vol	vol	NOUN
cajgh-231	145	2	19	19	NUM
cajgh-231	145	3	(	(	PUNCT
cajgh-231	145	4	3)2000:204	3)2000:204	NUM
cajgh-231	145	5	-	-	SYM
cajgh-231	145	6	212	212	NUM
cajgh-231	145	7	.	.	PUNCT
cajgh-231	146	1	3	3	X
cajgh-231	146	2	.	.	X
cajgh-231	146	3	davie	davie	PROPN
cajgh-231	146	4	ca	ca	PROPN
cajgh-231	146	5	.	.	PUNCT
cajgh-231	147	1	a	a	DET
cajgh-231	147	2	review	review	NOUN
cajgh-231	147	3	of	of	ADP
cajgh-231	147	4	parkinson	parkinson	NOUN
cajgh-231	147	5	's	's	PART
cajgh-231	147	6	disease	disease	NOUN
cajgh-231	147	7	.	.	PUNCT
cajgh-231	148	1	vol	vol	NOUN
cajgh-231	148	2	862008:109	862008:109	NUM
cajgh-231	148	3	-	-	SYM
cajgh-231	148	4	127	127	NUM
cajgh-231	148	5	.	.	PUNCT
cajgh-231	149	1	4	4	NUM
cajgh-231	149	2	.	.	X
cajgh-231	149	3	beitz	beitz	PROPN
cajgh-231	149	4	jm	jm	PROPN
cajgh-231	149	5	.	.	PROPN
cajgh-231	149	6	parkinson	parkinson	PROPN
cajgh-231	149	7	's	's	PART
cajgh-231	149	8	disease	disease	NOUN
cajgh-231	149	9	:	:	PUNCT
cajgh-231	149	10	a	a	DET
cajgh-231	149	11	review	review	NOUN
cajgh-231	149	12	.	.	PUNCT
cajgh-231	150	1	front	front	PROPN
cajgh-231	150	2	biosci	biosci	PROPN
cajgh-231	150	3	.	.	PUNCT
cajgh-231	151	1	vol	vol	NOUN
cajgh-231	151	2	62014:65	62014:65	NUM
cajgh-231	151	3	-	-	SYM
cajgh-231	151	4	74	74	NUM
cajgh-231	151	5	.	.	PUNCT
cajgh-231	152	1	5	5	NUM
cajgh-231	152	2	.	.	X
cajgh-231	152	3	imputation	imputation	NOUN
cajgh-231	152	4	of	of	ADP
cajgh-231	152	5	sequence	sequence	NOUN
cajgh-231	152	6	variants	variant	NOUN
cajgh-231	152	7	for	for	ADP
cajgh-231	152	8	identification	identification	NOUN
cajgh-231	152	9	of	of	ADP
cajgh-231	152	10	genetic	genetic	ADJ
cajgh-231	152	11	risks	risk	NOUN
cajgh-231	152	12	for	for	ADP
cajgh-231	152	13	parkinson	parkinson	NOUN
cajgh-231	152	14	's	's	PART
cajgh-231	152	15	disease	disease	NOUN
cajgh-231	152	16	:	:	PUNCT
cajgh-231	152	17	a	a	DET
cajgh-231	152	18	meta	meta	ADJ
cajgh-231	152	19	-	-	PUNCT
cajgh-231	152	20	analysis	analysis	NOUN
cajgh-231	152	21	of	of	ADP
cajgh-231	152	22	genome	genome	NOUN
cajgh-231	152	23	-	-	PUNCT
cajgh-231	152	24	wide	wide	ADJ
cajgh-231	152	25	association	association	NOUN
cajgh-231	152	26	studies	study	NOUN
cajgh-231	152	27	.	.	PUNCT
cajgh-231	153	1	lancet	lancet	PROPN
cajgh-231	153	2	.	.	PUNCT
cajgh-231	154	1	vol	vol	NOUN
cajgh-231	154	2	377	377	NUM
cajgh-231	154	3	(	(	PUNCT
cajgh-231	154	4	9766)2011:641–649	9766)2011:641–649	NOUN
cajgh-231	154	5	.	.	PUNCT
cajgh-231	155	1	6	6	NUM
cajgh-231	155	2	.	.	NUM
cajgh-231	155	3	nalls	nalls	PROPN
cajgh-231	155	4	ma	ma	PROPN
cajgh-231	155	5	,	,	PUNCT
cajgh-231	155	6	pankratz	pankratz	NOUN
cajgh-231	155	7	n	n	CCONJ
cajgh-231	155	8	,	,	PUNCT
cajgh-231	155	9	lill	lill	NOUN
cajgh-231	155	10	cm	cm	PROPN
cajgh-231	155	11	,	,	PUNCT
cajgh-231	155	12	et	et	PROPN
cajgh-231	155	13	al	al	PROPN
cajgh-231	155	14	.	.	PROPN
cajgh-231	156	1	largescale	largescale	PROPN
cajgh-231	156	2	meta	meta	ADJ
cajgh-231	156	3	-	-	PUNCT
cajgh-231	156	4	analysis	analysis	NOUN
cajgh-231	156	5	of	of	ADP
cajgh-231	156	6	genome	genome	NOUN
cajgh-231	156	7	-	-	PUNCT
cajgh-231	156	8	wide	wide	ADJ
cajgh-231	156	9	association	association	NOUN
cajgh-231	156	10	data	datum	NOUN
cajgh-231	156	11	identifies	identify	VERB
cajgh-231	156	12	six	six	NUM
cajgh-231	156	13	new	new	ADJ
cajgh-231	156	14	risk	risk	NOUN
cajgh-231	156	15	loci	loci	NOUN
cajgh-231	156	16	for	for	ADP
cajgh-231	156	17	parkinson	parkinson	NOUN
cajgh-231	156	18	's	's	PART
cajgh-231	156	19	disease	disease	NOUN
cajgh-231	156	20	.	.	PUNCT
cajgh-231	157	1	nat	nat	PROPN
cajgh-231	157	2	genet	genet	PROPN
cajgh-231	157	3	.	.	PUNCT
cajgh-231	158	1	vol	vol	NOUN
cajgh-231	158	2	462014:989–993	462014:989–993	NOUN
cajgh-231	158	3	.	.	PUNCT
cajgh-231	159	1	7	7	X
cajgh-231	159	2	.	.	X
cajgh-231	159	3	monte	monte	PROPN
cajgh-231	159	4	dad	dad	PROPN
cajgh-231	159	5	,	,	PUNCT
cajgh-231	159	6	lavasani	lavasani	PROPN
cajgh-231	159	7	m	m	PROPN
cajgh-231	159	8	,	,	PUNCT
cajgh-231	159	9	manning	man	VERB
cajgh-231	159	10	-	-	PUNCT
cajgh-231	159	11	bog	bog	NOUN
cajgh-231	159	12	ab	ab	PROPN
cajgh-231	159	13	.	.	PUNCT
cajgh-231	159	14	environmental	environmental	ADJ
cajgh-231	159	15	factors	factor	NOUN
cajgh-231	159	16	in	in	ADP
cajgh-231	159	17	parkinson	parkinson	NOUN
cajgh-231	159	18	's	's	PART
cajgh-231	159	19	disease	disease	NOUN
cajgh-231	159	20	.	.	PUNCT
cajgh-231	160	1	neurotoxicology	neurotoxicology	NOUN
cajgh-231	160	2	.	.	PUNCT
cajgh-231	161	1	vol	vol	NOUN
cajgh-231	161	2	23	23	NUM
cajgh-231	161	3	(	(	PUNCT
cajgh-231	161	4	4	4	NUM
cajgh-231	161	5	-	-	NUM
cajgh-231	161	6	5)2002:487	5)2002:487	NUM
cajgh-231	161	7	-	-	PUNCT
cajgh-231	161	8	502	502	NUM
cajgh-231	161	9	.	.	NOUN
cajgh-231	161	10	8	8	NUM
cajgh-231	161	11	.	.	PUNCT
cajgh-231	162	1	takahashi	takahashi	PROPN
cajgh-231	162	2	m	m	PROPN
cajgh-231	162	3	,	,	PUNCT
cajgh-231	162	4	yamada	yamada	PROPN
cajgh-231	162	5	t.	t.	PROPN
cajgh-231	162	6	viral	viral	ADJ
cajgh-231	162	7	etiology	etiology	NOUN
cajgh-231	162	8	for	for	ADP
cajgh-231	162	9	parkinson	parkinson	NOUN
cajgh-231	162	10	's	's	PART
cajgh-231	162	11	disease	disease	NOUN
cajgh-231	162	12	a	a	DET
cajgh-231	162	13	possible	possible	ADJ
cajgh-231	162	14	role	role	NOUN
cajgh-231	162	15	of	of	ADP
cajgh-231	162	16	influenza	influenza	NOUN
cajgh-231	162	17	a	a	DET
cajgh-231	162	18	virus	virus	NOUN
cajgh-231	162	19	infection	infection	NOUN
cajgh-231	162	20	.	.	PUNCT
cajgh-231	163	1	jpn	jpn	PROPN
cajgh-231	163	2	j	j	PROPN
cajgh-231	163	3	infect	infect	PROPN
cajgh-231	163	4	dis	dis	PROPN
cajgh-231	163	5	.	.	PUNCT
cajgh-231	164	1	vol	vol	NOUN
cajgh-231	164	2	52	52	NUM
cajgh-231	164	3	(	(	PUNCT
cajgh-231	164	4	3)1999:89	3)1999:89	NOUN
cajgh-231	164	5	-	-	SYM
cajgh-231	164	6	98	98	NUM
cajgh-231	164	7	.	.	PUNCT
cajgh-231	165	1	9	9	X
cajgh-231	165	2	.	.	X
cajgh-231	165	3	olanow	olanow	PROPN
cajgh-231	165	4	cw	cw	PROPN
cajgh-231	165	5	,	,	PUNCT
cajgh-231	165	6	prusiner	prusiner	NOUN
cajgh-231	165	7	sb	sb	PROPN
cajgh-231	165	8	.	.	PROPN
cajgh-231	165	9	is	be	AUX
cajgh-231	165	10	parkinson	parkinson	NOUN
cajgh-231	165	11	's	's	PART
cajgh-231	165	12	disease	disease	NOUN
cajgh-231	165	13	a	a	DET
cajgh-231	165	14	prion	prion	NOUN
cajgh-231	165	15	disorder	disorder	NOUN
cajgh-231	165	16	?	?	PUNCT
cajgh-231	166	1	proc	proc	PROPN
cajgh-231	166	2	natl	natl	PROPN
cajgh-231	166	3	acad	acad	PROPN
cajgh-231	166	4	sci	sci	PROPN
cajgh-231	166	5	u	u	PROPN
cajgh-231	166	6	s	s	NOUN
cajgh-231	166	7	a.	a.	NOUN
cajgh-231	166	8	vol	vol	NOUN
cajgh-231	166	9	106	106	NUM
cajgh-231	166	10	(	(	PUNCT
cajgh-231	166	11	31)2009:12571	31)2009:12571	NUM
cajgh-231	166	12	-	-	SYM
cajgh-231	166	13	12572	12572	NUM
cajgh-231	166	14	.	.	PUNCT
cajgh-231	167	1	10	10	NUM
cajgh-231	167	2	.	.	PUNCT
cajgh-231	168	1	lerner	lerner	PROPN
cajgh-231	168	2	a	a	DET
cajgh-231	168	3	,	,	PUNCT
cajgh-231	168	4	bagic	bagic	ADJ
cajgh-231	168	5	a.	a.	NOUN
cajgh-231	168	6	olfactory	olfactory	NOUN
cajgh-231	168	7	pathogenesis	pathogenesis	NOUN
cajgh-231	168	8	of	of	ADP
cajgh-231	168	9	idiopathic	idiopathic	ADJ
cajgh-231	168	10	parkinson	parkinson	NOUN
cajgh-231	168	11	disease	disease	NOUN
cajgh-231	168	12	revisited	revisit	VERB
cajgh-231	168	13	.	.	PUNCT
cajgh-231	169	1	mov	mov	NOUN
cajgh-231	169	2	disord	disord	NOUN
cajgh-231	169	3	.	.	PUNCT
cajgh-231	170	1	vol	vol	NOUN
cajgh-231	170	2	23	23	NUM
cajgh-231	170	3	(	(	PUNCT
cajgh-231	170	4	8)2008:1076	8)2008:1076	NUM
cajgh-231	170	5	-	-	SYM
cajgh-231	170	6	1084	1084	NUM
cajgh-231	170	7	.	.	PUNCT
cajgh-231	171	1	11	11	NUM
cajgh-231	171	2	.	.	PUNCT
cajgh-231	171	3	phillips	phillips	PROPN
cajgh-231	171	4	rj	rj	PROPN
cajgh-231	171	5	,	,	PUNCT
cajgh-231	171	6	walter	walter	PROPN
cajgh-231	171	7	gc	gc	PROPN
cajgh-231	171	8	,	,	PUNCT
cajgh-231	171	9	wilder	wilder	ADJ
cajgh-231	171	10	sl	sl	NOUN
cajgh-231	171	11	,	,	PUNCT
cajgh-231	171	12	baronowsky	baronowsky	ADJ
cajgh-231	171	13	ea	ea	PROPN
cajgh-231	171	14	,	,	PUNCT
cajgh-231	171	15	powley	powley	VERB
cajgh-231	171	16	tl	tl	PROPN
cajgh-231	171	17	.	.	PUNCT
cajgh-231	171	18	alpha	alpha	PROPN
cajgh-231	171	19	-	-	PUNCT
cajgh-231	171	20	synucleinimmunopositive	synucleinimmunopositive	ADJ
cajgh-231	171	21	myenteric	myenteric	ADJ
cajgh-231	171	22	neurons	neuron	NOUN
cajgh-231	171	23	and	and	CCONJ
cajgh-231	171	24	vagal	vagal	ADJ
cajgh-231	171	25	preganglionic	preganglionic	ADJ
cajgh-231	171	26	terminals	terminal	NOUN
cajgh-231	171	27	:	:	PUNCT
cajgh-231	171	28	autonomic	autonomic	ADJ
cajgh-231	171	29	pathway	pathway	NOUN
cajgh-231	171	30	implicated	implicate	VERB
cajgh-231	171	31	in	in	ADP
cajgh-231	171	32	parkinson	parkinson	NOUN
cajgh-231	171	33	's	's	PART
cajgh-231	171	34	disease	disease	NOUN
cajgh-231	171	35	?	?	PUNCT
cajgh-231	172	1	neuroscience	neuroscience	NOUN
cajgh-231	172	2	.	.	PUNCT
cajgh-231	173	1	vol	vol	NOUN
cajgh-231	173	2	153	153	NUM
cajgh-231	173	3	(	(	PUNCT
cajgh-231	173	4	3)2008:733	3)2008:733	NUM
cajgh-231	173	5	-	-	SYM
cajgh-231	173	6	750	750	NUM
cajgh-231	173	7	.	.	PUNCT
cajgh-231	173	8	12	12	NUM
cajgh-231	173	9	.	.	PUNCT
cajgh-231	174	1	hawkes	hawkes	PROPN
cajgh-231	174	2	ch	ch	PROPN
cajgh-231	174	3	,	,	PUNCT
cajgh-231	174	4	del	del	PROPN
cajgh-231	174	5	tredici	tredici	PROPN
cajgh-231	174	6	k	k	PROPN
cajgh-231	174	7	,	,	PUNCT
cajgh-231	174	8	braak	braak	PROPN
cajgh-231	174	9	h.	h.	PROPN
cajgh-231	174	10	parkinson	parkinson	PROPN
cajgh-231	174	11	's	's	PART
cajgh-231	174	12	disease	disease	NOUN
cajgh-231	174	13	:	:	PUNCT
cajgh-231	174	14	a	a	DET
cajgh-231	174	15	dual	dual	ADV
cajgh-231	174	16	-	-	PUNCT
cajgh-231	174	17	hit	hit	VERB
cajgh-231	174	18	hypothesis	hypothesis	NOUN
cajgh-231	174	19	.	.	PUNCT
cajgh-231	175	1	neuropath	neuropath	NOUN
cajgh-231	175	2	appl	appl	PROPN
cajgh-231	175	3	neuro	neuro	PROPN
cajgh-231	175	4	.	.	PUNCT
cajgh-231	176	1	vol	vol	NOUN
cajgh-231	176	2	33	33	NUM
cajgh-231	176	3	(	(	PUNCT
cajgh-231	176	4	6)2007:599614	6)2007:599614	NUM
cajgh-231	176	5	.	.	X
cajgh-231	176	6	13	13	NUM
cajgh-231	176	7	.	.	PUNCT
cajgh-231	177	1	desplats	desplat	NOUN
cajgh-231	177	2	p	p	PROPN
cajgh-231	177	3	,	,	PUNCT
cajgh-231	177	4	lee	lee	PROPN
cajgh-231	177	5	h	h	PROPN
cajgh-231	177	6	-	-	PUNCT
cajgh-231	177	7	j	j	PROPN
cajgh-231	177	8	,	,	PUNCT
cajgh-231	177	9	bae	bae	PROPN
cajgh-231	177	10	e	e	PROPN
cajgh-231	177	11	-	-	PROPN
cajgh-231	177	12	j	j	PROPN
cajgh-231	177	13	,	,	PUNCT
cajgh-231	177	14	patrick	patrick	PROPN
cajgh-231	177	15	c	c	PROPN
cajgh-231	177	16	,	,	PUNCT
cajgh-231	177	17	rockenstein	rockenstein	PROPN
cajgh-231	177	18	e	e	NOUN
cajgh-231	177	19	,	,	PUNCT
cajgh-231	177	20	crews	crew	NOUN
cajgh-231	177	21	l.	l.	PROPN
cajgh-231	177	22	inclusion	inclusion	NOUN
cajgh-231	177	23	formation	formation	NOUN
cajgh-231	177	24	and	and	CCONJ
cajgh-231	177	25	neuronal	neuronal	ADJ
cajgh-231	177	26	cell	cell	NOUN
cajgh-231	177	27	death	death	NOUN
cajgh-231	177	28	through	through	ADP
cajgh-231	177	29	neuron	neuron	PROPN
cajgh-231	177	30	-	-	PUNCT
cajgh-231	177	31	toneuron	toneuron	NOUN
cajgh-231	177	32	transmission	transmission	NOUN
cajgh-231	177	33	of	of	ADP
cajgh-231	177	34	α	α	NOUN
cajgh-231	177	35	-	-	PUNCT
cajgh-231	177	36	synuclein	synuclein	NOUN
cajgh-231	177	37	.	.	PUNCT
cajgh-231	178	1	vol	vol	NOUN
cajgh-231	178	2	106	106	NUM
cajgh-231	178	3	(	(	PUNCT
cajgh-231	178	4	31)2009:13010	31)2009:13010	NUM
cajgh-231	178	5	-	-	SYM
cajgh-231	178	6	13015	13015	NUM
cajgh-231	178	7	.	.	PUNCT
cajgh-231	179	1	14	14	NUM
cajgh-231	179	2	.	.	X
cajgh-231	180	1	henchcliffe	henchcliffe	PROPN
cajgh-231	180	2	c	c	PROPN
cajgh-231	180	3	,	,	PUNCT
cajgh-231	180	4	beal	beal	NOUN
cajgh-231	180	5	mf	mf	NOUN
cajgh-231	180	6	.	.	PROPN
cajgh-231	180	7	mitochondrial	mitochondrial	ADJ
cajgh-231	180	8	biology	biology	NOUN
cajgh-231	180	9	and	and	CCONJ
cajgh-231	180	10	oxidative	oxidative	ADJ
cajgh-231	180	11	stress	stress	NOUN
cajgh-231	180	12	in	in	ADP
cajgh-231	180	13	parkinson	parkinson	NOUN
cajgh-231	180	14	disease	disease	NOUN
cajgh-231	180	15	pathogenesis	pathogenesis	NOUN
cajgh-231	180	16	.	.	PUNCT
cajgh-231	181	1	nat	nat	PROPN
cajgh-231	181	2	clin	clin	PROPN
cajgh-231	181	3	pract	pract	PROPN
cajgh-231	181	4	neuro	neuro	PROPN
cajgh-231	181	5	.	.	PUNCT
cajgh-231	182	1	vol	vol	NOUN
cajgh-231	182	2	4	4	NUM
cajgh-231	182	3	(	(	PUNCT
cajgh-231	182	4	11)2008:600	11)2008:600	NUM
cajgh-231	182	5	-	-	SYM
cajgh-231	182	6	609	609	NUM
cajgh-231	182	7	.	.	PUNCT
cajgh-231	183	1	15	15	NUM
cajgh-231	183	2	.	.	PUNCT
cajgh-231	183	3	swerdlow	swerdlow	PROPN
cajgh-231	183	4	rh	rh	PROPN
cajgh-231	183	5	.	.	PROPN
cajgh-231	183	6	does	do	AUX
cajgh-231	183	7	mitochondrial	mitochondrial	ADJ
cajgh-231	183	8	dna	dna	PROPN
cajgh-231	183	9	play	play	VERB
cajgh-231	183	10	a	a	DET
cajgh-231	183	11	role	role	NOUN
cajgh-231	183	12	in	in	ADP
cajgh-231	183	13	parkinson	parkinson	NOUN
cajgh-231	183	14	's	's	PART
cajgh-231	183	15	disease	disease	NOUN
cajgh-231	183	16	?	?	PUNCT
cajgh-231	184	1	a	a	DET
cajgh-231	184	2	review	review	NOUN
cajgh-231	184	3	of	of	ADP
cajgh-231	184	4	cybrid	cybrid	PROPN
cajgh-231	184	5	and	and	CCONJ
cajgh-231	184	6	other	other	ADJ
cajgh-231	184	7	supportive	supportive	ADJ
cajgh-231	184	8	evidence	evidence	NOUN
cajgh-231	184	9	.	.	PUNCT
cajgh-231	185	1	antioxid	antioxid	VERB
cajgh-231	185	2	redox	redox	NOUN
cajgh-231	185	3	signal	signal	NOUN
cajgh-231	185	4	.	.	PUNCT
cajgh-231	186	1	vol	vol	NOUN
cajgh-231	186	2	16(9)2012:950964	16(9)2012:950964	NUM
cajgh-231	186	3	.	.	PUNCT
cajgh-231	187	1	16	16	NUM
cajgh-231	187	2	.	.	PUNCT
cajgh-231	188	1	monahan	monahan	PROPN
cajgh-231	188	2	aj	aj	PROPN
cajgh-231	188	3	,	,	PUNCT
cajgh-231	188	4	warren	warren	PROPN
cajgh-231	188	5	m	m	PROPN
cajgh-231	188	6	,	,	PUNCT
cajgh-231	188	7	carvey	carvey	NOUN
cajgh-231	188	8	pm	pm	NOUN
cajgh-231	188	9	.	.	PUNCT
cajgh-231	189	1	neuroinflammation	neuroinflammation	NOUN
cajgh-231	189	2	and	and	CCONJ
cajgh-231	189	3	peripheral	peripheral	ADJ
cajgh-231	189	4	immune	immune	ADJ
cajgh-231	189	5	infiltration	infiltration	NOUN
cajgh-231	189	6	in	in	ADP
cajgh-231	189	7	parkinson	parkinson	NOUN
cajgh-231	189	8	's	's	PART
cajgh-231	189	9	disease	disease	NOUN
cajgh-231	189	10	:	:	PUNCT
cajgh-231	189	11	an	an	DET
cajgh-231	189	12	autoimmune	autoimmune	ADJ
cajgh-231	189	13	hypothesis	hypothesis	NOUN
cajgh-231	189	14	.	.	PUNCT
cajgh-231	190	1	cell	cell	NOUN
cajgh-231	190	2	transplant	transplant	NOUN
cajgh-231	190	3	.	.	PUNCT
cajgh-231	191	1	vol	vol	NOUN
cajgh-231	191	2	17	17	NUM
cajgh-231	191	3	(	(	PUNCT
cajgh-231	191	4	4)2008:363	4)2008:363	NUM
cajgh-231	191	5	-	-	SYM
cajgh-231	191	6	372	372	NUM
cajgh-231	191	7	.	.	NOUN
cajgh-231	191	8	17	17	NUM
cajgh-231	191	9	.	.	PUNCT
cajgh-231	192	1	whitton	whitton	PROPN
cajgh-231	192	2	p.	p.	NOUN
cajgh-231	192	3	inflammation	inflammation	NOUN
cajgh-231	192	4	as	as	ADP
cajgh-231	192	5	a	a	DET
cajgh-231	192	6	causative	causative	ADJ
cajgh-231	192	7	factor	factor	NOUN
cajgh-231	192	8	in	in	ADP
cajgh-231	192	9	the	the	DET
cajgh-231	192	10	aetiology	aetiology	NOUN
cajgh-231	192	11	of	of	ADP
cajgh-231	192	12	parkinson	parkinson	NOUN
cajgh-231	192	13	's	's	PART
cajgh-231	192	14	disease	disease	NOUN
cajgh-231	192	15	.	.	PUNCT
cajgh-231	193	1	br	br	PROPN
cajgh-231	193	2	j	j	PROPN
cajgh-231	193	3	pharmacol	pharmacol	PROPN
cajgh-231	193	4	.	.	PUNCT
cajgh-231	194	1	vol	vol	NOUN
cajgh-231	194	2	150	150	NUM
cajgh-231	194	3	(	(	PUNCT
cajgh-231	194	4	8)2007:963	8)2007:963	NUM
cajgh-231	194	5	-	-	SYM
cajgh-231	194	6	976	976	NUM
cajgh-231	194	7	.	.	PUNCT
cajgh-231	194	8	18	18	NUM
cajgh-231	194	9	.	.	PUNCT
cajgh-231	195	1	valente	valente	PROPN
cajgh-231	195	2	axcn	axcn	PROPN
cajgh-231	195	3	,	,	PUNCT
cajgh-231	195	4	sousa	sousa	PROPN
cajgh-231	195	5	jab	jab	PROPN
cajgh-231	195	6	,	,	PUNCT
cajgh-231	195	7	outeiro	outeiro	NOUN
cajgh-231	195	8	tf	tf	PROPN
cajgh-231	195	9	,	,	PUNCT
cajgh-231	195	10	ferreira	ferreira	PROPN
cajgh-231	195	11	l.	l.	PROPN
cajgh-231	195	12	a	a	DET
cajgh-231	195	13	stem	stem	NOUN
cajgh-231	195	14	-	-	PUNCT
cajgh-231	195	15	cell	cell	NOUN
cajgh-231	195	16	ageing	age	VERB
cajgh-231	195	17	hypothesis	hypothesis	NOUN
cajgh-231	195	18	on	on	ADP
cajgh-231	195	19	the	the	DET
cajgh-231	195	20	origin	origin	NOUN
cajgh-231	195	21	of	of	ADP
cajgh-231	195	22	parkinson	parkinson	NOUN
cajgh-231	195	23	's	's	PART
cajgh-231	195	24	disease	disease	NOUN
cajgh-231	195	25	.	.	PUNCT
cajgh-231	196	1	in	in	ADP
cajgh-231	196	2	:	:	PUNCT
cajgh-231	196	3	valente	valente	PROPN
cajgh-231	196	4	axcn	axcn	PROPN
cajgh-231	196	5	,	,	PUNCT
cajgh-231	196	6	ed	ed	NOUN
cajgh-231	196	7	.	.	PUNCT
cajgh-231	197	1	science	science	NOUN
cajgh-231	197	2	and	and	CCONJ
cajgh-231	197	3	engineering	engineering	NOUN
cajgh-231	197	4	in	in	ADP
cajgh-231	197	5	highthroughput	highthroughput	ADJ
cajgh-231	197	6	biology	biology	NOUN
cajgh-231	197	7	including	include	VERB
cajgh-231	197	8	a	a	DET
cajgh-231	197	9	theory	theory	NOUN
cajgh-231	197	10	on	on	ADP
cajgh-231	197	11	parkinson	parkinson	NOUN
cajgh-231	197	12	's	's	PART
cajgh-231	197	13	disease	disease	NOUN
cajgh-231	197	14	:	:	PUNCT
cajgh-231	197	15	lulu	lulu	NOUN
cajgh-231	197	16	books	book	NOUN
cajgh-231	197	17	;	;	PUNCT
cajgh-231	197	18	2011:43	2011:43	NUM
cajgh-231	197	19	-	-	SYM
cajgh-231	197	20	73	73	NUM
cajgh-231	197	21	.	.	PUNCT
cajgh-231	198	1	19	19	NUM
cajgh-231	198	2	.	.	PUNCT
cajgh-231	198	3	sánchez	sánchez	NOUN
cajgh-231	198	4	-	-	PUNCT
cajgh-231	198	5	danés	danés	PROPN
cajgh-231	198	6	a	a	PRON
cajgh-231	198	7	,	,	PUNCT
cajgh-231	198	8	richaud	richaud	ADJ
cajgh-231	198	9	-	-	PUNCT
cajgh-231	198	10	patin	patin	PROPN
cajgh-231	198	11	y	y	PROPN
cajgh-231	198	12	,	,	PUNCT
cajgh-231	198	13	carballocarbajal	carballocarbajal	VERB
cajgh-231	198	14	i	i	PRON
cajgh-231	198	15	,	,	PUNCT
cajgh-231	198	16	et	et	PROPN
cajgh-231	198	17	al	al	PROPN
cajgh-231	198	18	.	.	PUNCT
cajgh-231	198	19	disease	disease	NOUN
cajgh-231	198	20	-	-	PUNCT
cajgh-231	198	21	specific	specific	ADJ
cajgh-231	198	22	phenotypes	phenotype	NOUN
cajgh-231	198	23	in	in	ADP
cajgh-231	198	24	dopamine	dopamine	NOUN
cajgh-231	198	25	neurons	neuron	NOUN
cajgh-231	198	26	from	from	ADP
cajgh-231	198	27	human	human	ADJ
cajgh-231	198	28	ips	ips	PROPN
cajgh-231	198	29	-	-	PUNCT
cajgh-231	198	30	based	base	VERB
cajgh-231	198	31	models	model	NOUN
cajgh-231	198	32	of	of	ADP
cajgh-231	198	33	genetic	genetic	ADJ
cajgh-231	198	34	and	and	CCONJ
cajgh-231	198	35	sporadic	sporadic	ADJ
cajgh-231	198	36	parkinson	parkinson	NOUN
cajgh-231	198	37	's	's	PART
cajgh-231	198	38	disease	disease	NOUN
cajgh-231	198	39	.	.	PUNCT
cajgh-231	199	1	embo	embo	NOUN
cajgh-231	199	2	mol	mol	ADP
cajgh-231	199	3	med	med	PROPN
cajgh-231	199	4	.	.	PUNCT
cajgh-231	200	1	vol	vol	NOUN
cajgh-231	200	2	42012:380	42012:380	NUM
cajgh-231	200	3	-	-	SYM
cajgh-231	200	4	395	395	NUM
cajgh-231	200	5	.	.	NOUN
cajgh-231	200	6	20	20	NUM
cajgh-231	200	7	.	.	PUNCT
cajgh-231	201	1	woodard	woodard	PROPN
cajgh-231	201	2	cm	cm	PROPN
cajgh-231	201	3	,	,	PUNCT
cajgh-231	201	4	campos	campos	PROPN
cajgh-231	201	5	ba	ba	PROPN
cajgh-231	201	6	,	,	PUNCT
cajgh-231	201	7	kuo	kuo	PROPN
cajgh-231	201	8	s	s	PROPN
cajgh-231	201	9	-	-	PROPN
cajgh-231	201	10	h	h	NOUN
cajgh-231	201	11	,	,	PUNCT
cajgh-231	201	12	et	et	PROPN
cajgh-231	201	13	al	al	PROPN
cajgh-231	201	14	.	.	PUNCT
cajgh-231	201	15	ipsc	ipsc	PROPN
cajgh-231	201	16	-	-	PUNCT
cajgh-231	201	17	derived	derive	VERB
cajgh-231	201	18	dopamine	dopamine	NOUN
cajgh-231	201	19	neurons	neuron	NOUN
cajgh-231	201	20	reveal	reveal	VERB
cajgh-231	201	21	differences	difference	NOUN
cajgh-231	201	22	between	between	ADP
cajgh-231	201	23	monozygotic	monozygotic	ADJ
cajgh-231	201	24	twins	twin	NOUN
cajgh-231	201	25	discordant	discordant	ADJ
cajgh-231	201	26	for	for	ADP
cajgh-231	201	27	parkinson	parkinson	NOUN
cajgh-231	201	28	's	's	PART
cajgh-231	201	29	disease	disease	NOUN
cajgh-231	201	30	.	.	PUNCT
cajgh-231	202	1	cell	cell	NOUN
cajgh-231	202	2	reports	report	VERB
cajgh-231	202	3	.	.	PUNCT
cajgh-231	203	1	vol	vol	NOUN
cajgh-231	203	2	92014:1173	92014:1173	NUM
cajgh-231	203	3	-	-	SYM
cajgh-231	203	4	1182	1182	NUM
cajgh-231	203	5	.	.	PUNCT
cajgh-231	204	1	21	21	NUM
cajgh-231	204	2	.	.	PUNCT
cajgh-231	205	1	tanner	tanner	PROPN
cajgh-231	205	2	cm	cm	PROPN
cajgh-231	205	3	,	,	PUNCT
cajgh-231	205	4	ottman	ottman	ADJ
cajgh-231	205	5	r	r	NOUN
cajgh-231	205	6	,	,	PUNCT
cajgh-231	205	7	goldman	goldman	NOUN
cajgh-231	205	8	sm	sm	PROPN
cajgh-231	205	9	,	,	PUNCT
cajgh-231	205	10	et	et	PROPN
cajgh-231	205	11	al	al	PROPN
cajgh-231	205	12	.	.	PROPN
cajgh-231	205	13	parkinson	parkinson	NOUN
cajgh-231	205	14	disease	disease	NOUN
cajgh-231	205	15	in	in	ADP
cajgh-231	205	16	twins	twin	NOUN
cajgh-231	205	17	:	:	PUNCT
cajgh-231	205	18	an	an	DET
cajgh-231	205	19	etiologic	etiologic	ADJ
cajgh-231	205	20	study	study	NOUN
cajgh-231	205	21	.	.	PUNCT
cajgh-231	206	1	jama	jama	PROPN
cajgh-231	206	2	j	j	PROPN
cajgh-231	206	3	am	be	AUX
cajgh-231	206	4	med	med	ADJ
cajgh-231	206	5	assoc	assoc	PROPN
cajgh-231	206	6	.	.	PUNCT
cajgh-231	207	1	vol	vol	NOUN
cajgh-231	207	2	2811999:341346	2811999:341346	NUM
cajgh-231	207	3	.	.	PROPN
cajgh-231	207	4	22	22	NUM
cajgh-231	207	5	.	.	PUNCT
cajgh-231	208	1	wiredefeldt	wiredefeldt	PROPN
cajgh-231	208	2	k	k	PROPN
cajgh-231	208	3	,	,	PUNCT
cajgh-231	208	4	gatz	gatz	PROPN
cajgh-231	208	5	m	m	PROPN
cajgh-231	208	6	,	,	PUNCT
cajgh-231	208	7	reynolds	reynolds	PROPN
cajgh-231	208	8	ca	ca	PROPN
cajgh-231	208	9	,	,	PUNCT
cajgh-231	208	10	prescott	prescott	PROPN
cajgh-231	208	11	ca	ca	PROPN
cajgh-231	208	12	,	,	PUNCT
cajgh-231	208	13	pedersen	pedersen	PROPN
cajgh-231	208	14	nl	nl	PROPN
cajgh-231	208	15	.	.	PUNCT
cajgh-231	208	16	heritability	heritability	NOUN
cajgh-231	208	17	of	of	ADP
cajgh-231	208	18	parkinson	parkinson	NOUN
cajgh-231	208	19	disease	disease	NOUN
cajgh-231	208	20	in	in	ADP
cajgh-231	208	21	swedish	swedish	ADJ
cajgh-231	208	22	twins	twin	NOUN
cajgh-231	208	23	:	:	PUNCT
cajgh-231	208	24	a	a	DET
cajgh-231	208	25	longitudinal	longitudinal	ADJ
cajgh-231	208	26	study	study	NOUN
cajgh-231	208	27	.	.	PUNCT
cajgh-231	209	1	neurobiol	neurobiol	PROPN
cajgh-231	209	2	aging	aging	NOUN
cajgh-231	209	3	.	.	PUNCT
cajgh-231	210	1	vol	vol	NOUN
cajgh-231	210	2	322011:1923.e19211923.e1928	322011:1923.e19211923.e1928	NUM
cajgh-231	210	3	.	.	PUNCT
cajgh-231	211	1	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	211	2	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	211	3	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	211	4	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	211	5	valente	valente	NOUN
cajgh-231	211	6	this	this	DET
cajgh-231	211	7	work	work	NOUN
cajgh-231	211	8	is	be	AUX
cajgh-231	211	9	licensed	license	VERB
cajgh-231	211	10	under	under	ADP
cajgh-231	211	11	a	a	DET
cajgh-231	211	12	creative	creative	ADJ
cajgh-231	211	13	commons	common	NOUN
cajgh-231	211	14	attribution	attribution	NOUN
cajgh-231	211	15	4.0	4.0	NUM
cajgh-231	211	16	united	unite	VERB
cajgh-231	211	17	states	states	PROPN
cajgh-231	211	18	license	license	NOUN
cajgh-231	211	19	.	.	PUNCT
cajgh-231	212	1	this	this	DET
cajgh-231	212	2	journal	journal	NOUN
cajgh-231	212	3	is	be	AUX
cajgh-231	212	4	published	publish	VERB
cajgh-231	212	5	by	by	ADP
cajgh-231	212	6	theuniversity	theuniversity	NOUN
cajgh-231	212	7	library	library	NOUN
cajgh-231	212	8	system	system	NOUN
cajgh-231	212	9	of	of	ADP
cajgh-231	212	10	the	the	DET
cajgh-231	212	11	university	university	PROPN
cajgh-231	212	12	of	of	ADP
cajgh-231	212	13	pittsburgh	pittsburgh	PROPN
cajgh-231	212	14	as	as	ADP
cajgh-231	212	15	part	part	NOUN
cajgh-231	212	16	of	of	ADP
cajgh-231	212	17	its	its	PRON
cajgh-231	212	18	d	d	NOUN
cajgh-231	212	19	-	-	PUNCT
cajgh-231	212	20	scribe	scribe	VERB
cajgh-231	212	21	digital	digital	ADJ
cajgh-231	212	22	publishing	publishing	NOUN
cajgh-231	212	23	program	program	NOUN
cajgh-231	212	24	and	and	CCONJ
cajgh-231	212	25	is	be	AUX
cajgh-231	212	26	cosponsored	cosponsor	VERB
cajgh-231	212	27	by	by	ADP
cajgh-231	212	28	the	the	DET
cajgh-231	212	29	university	university	PROPN
cajgh-231	212	30	of	of	ADP
cajgh-231	212	31	pittsburgh	pittsburgh	PROPN
cajgh-231	212	32	press	press	NOUN
cajgh-231	212	33	.	.	PUNCT
cajgh-231	213	1	central	central	ADJ
cajgh-231	213	2	asian	asian	ADJ
cajgh-231	213	3	journal	journal	NOUN
cajgh-231	213	4	of	of	ADP
cajgh-231	213	5	global	global	ADJ
cajgh-231	213	6	health	health	NOUN
cajgh-231	213	7	volume	volume	NOUN
cajgh-231	213	8	4	4	NUM
cajgh-231	213	9	,	,	PUNCT
cajgh-231	213	10	no	no	INTJ
cajgh-231	213	11	.	.	NOUN
cajgh-231	213	12	1	1	NUM
cajgh-231	213	13	(	(	PUNCT
cajgh-231	213	14	2015	2015	NUM
cajgh-231	213	15	)	)	PUNCT
cajgh-231	213	16	|	|	ADV
cajgh-231	213	17	issn	issn	VERB
cajgh-231	213	18	2166	2166	NUM
cajgh-231	213	19	-	-	SYM
cajgh-231	213	20	7403	7403	NUM
cajgh-231	213	21	(	(	PUNCT
cajgh-231	213	22	online	online	ADJ
cajgh-231	213	23	)	)	PUNCT
cajgh-231	213	24	|	|	ADV
cajgh-231	213	25	doi	doi	X
cajgh-231	213	26	10.5195	10.5195	NUM
cajgh-231	213	27	/	/	SYM
cajgh-231	213	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	213	29	23	23	NUM
cajgh-231	213	30	.	.	PUNCT
cajgh-231	214	1	valente	valente	PROPN
cajgh-231	214	2	axcn	axcn	PROPN
cajgh-231	214	3	,	,	PUNCT
cajgh-231	214	4	oliveira	oliveira	PROPN
cajgh-231	214	5	pj	pj	PROPN
cajgh-231	214	6	,	,	PUNCT
cajgh-231	214	7	khaiboullina	khaiboullina	PROPN
cajgh-231	214	8	sf	sf	PROPN
cajgh-231	214	9	,	,	PUNCT
cajgh-231	214	10	palotás	palotás	PROPN
cajgh-231	214	11	a	a	PRON
cajgh-231	214	12	,	,	PUNCT
cajgh-231	214	13	rizvanov	rizvanov	NOUN
cajgh-231	214	14	aa	aa	NOUN
cajgh-231	214	15	.	.	PUNCT
cajgh-231	215	1	biological	biological	ADJ
cajgh-231	215	2	insight	insight	NOUN
cajgh-231	215	3	,	,	PUNCT
cajgh-231	215	4	high	high	ADJ
cajgh-231	215	5	-	-	PUNCT
cajgh-231	215	6	throughput	throughput	NOUN
cajgh-231	215	7	datasets	dataset	NOUN
cajgh-231	215	8	and	and	CCONJ
cajgh-231	215	9	the	the	DET
cajgh-231	215	10	nature	nature	NOUN
cajgh-231	215	11	of	of	ADP
cajgh-231	215	12	neuro	neuro	NOUN
cajgh-231	215	13	-	-	PUNCT
cajgh-231	215	14	degenerative	degenerative	NOUN
cajgh-231	215	15	diseases	disease	NOUN
cajgh-231	215	16	.	.	PUNCT
cajgh-231	216	1	curr	curr	PROPN
cajgh-231	216	2	drug	drug	PROPN
cajgh-231	216	3	metab	metab	PROPN
cajgh-231	216	4	.	.	PUNCT
cajgh-231	217	1	vol	vol	NOUN
cajgh-231	217	2	14	14	NUM
cajgh-231	217	3	(	(	PUNCT
cajgh-231	217	4	7)2013:814	7)2013:814	NUM
cajgh-231	217	5	-	-	PUNCT
cajgh-231	217	6	818	818	NUM
cajgh-231	217	7	.	.	PUNCT
cajgh-231	218	1	24	24	NUM
cajgh-231	218	2	.	.	PUNCT
cajgh-231	219	1	simunovic	simunovic	PROPN
cajgh-231	219	2	f	f	PROPN
cajgh-231	219	3	,	,	PUNCT
cajgh-231	219	4	yi	yi	PROPN
cajgh-231	219	5	m	m	PROPN
cajgh-231	219	6	,	,	PUNCT
cajgh-231	219	7	wang	wang	PROPN
cajgh-231	219	8	y	y	PROPN
cajgh-231	219	9	,	,	PUNCT
cajgh-231	219	10	et	et	PROPN
cajgh-231	219	11	al	al	PROPN
cajgh-231	219	12	.	.	PROPN
cajgh-231	219	13	gene	gene	NOUN
cajgh-231	219	14	expression	expression	NOUN
cajgh-231	219	15	profiling	profiling	NOUN
cajgh-231	219	16	of	of	ADP
cajgh-231	219	17	substantia	substantia	PROPN
cajgh-231	219	18	nigra	nigra	PROPN
cajgh-231	219	19	dopamine	dopamine	NOUN
cajgh-231	219	20	neurons	neuron	NOUN
cajgh-231	219	21	:	:	PUNCT
cajgh-231	219	22	further	further	ADJ
cajgh-231	219	23	insights	insight	NOUN
cajgh-231	219	24	into	into	ADP
cajgh-231	219	25	parkinson	parkinson	NOUN
cajgh-231	219	26	's	's	PART
cajgh-231	219	27	disease	disease	NOUN
cajgh-231	219	28	pathology	pathology	NOUN
cajgh-231	219	29	.	.	PUNCT
cajgh-231	220	1	brain	brain	NOUN
cajgh-231	220	2	.	.	PUNCT
cajgh-231	221	1	vol	vol	NOUN
cajgh-231	221	2	1322009:1795	1322009:1795	NUM
cajgh-231	221	3	-	-	SYM
cajgh-231	221	4	1809	1809	NUM
cajgh-231	221	5	.	.	PUNCT
cajgh-231	222	1	25	25	NUM
cajgh-231	222	2	.	.	PUNCT
cajgh-231	222	3	scherzer	scherzer	PROPN
cajgh-231	222	4	cr	cr	PROPN
cajgh-231	222	5	,	,	PUNCT
cajgh-231	222	6	eklund	eklund	PROPN
cajgh-231	222	7	ac	ac	PROPN
cajgh-231	222	8	,	,	PUNCT
cajgh-231	222	9	morse	morse	PROPN
cajgh-231	222	10	lj	lj	PROPN
cajgh-231	222	11	,	,	PUNCT
cajgh-231	222	12	et	et	PROPN
cajgh-231	222	13	al	al	PROPN
cajgh-231	222	14	.	.	PUNCT
cajgh-231	223	1	molecular	molecular	ADJ
cajgh-231	223	2	markers	marker	NOUN
cajgh-231	223	3	of	of	ADP
cajgh-231	223	4	early	early	ADJ
cajgh-231	223	5	parkinson	parkinson	NOUN
cajgh-231	223	6	's	's	PART
cajgh-231	223	7	disease	disease	NOUN
cajgh-231	223	8	based	base	VERB
cajgh-231	223	9	on	on	ADP
cajgh-231	223	10	gene	gene	NOUN
cajgh-231	223	11	expression	expression	NOUN
cajgh-231	223	12	in	in	ADP
cajgh-231	223	13	blood	blood	NOUN
cajgh-231	223	14	.	.	PUNCT
cajgh-231	224	1	proc	proc	PROPN
cajgh-231	224	2	natl	natl	PROPN
cajgh-231	224	3	acad	acad	PROPN
cajgh-231	224	4	sci	sci	PROPN
cajgh-231	224	5	u	u	PROPN
cajgh-231	224	6	s	s	NOUN
cajgh-231	224	7	a.	a.	NOUN
cajgh-231	224	8	vol	vol	NOUN
cajgh-231	224	9	104	104	NUM
cajgh-231	224	10	(	(	PUNCT
cajgh-231	224	11	3)2007:955–960	3)2007:955–960	NUM
cajgh-231	224	12	.	.	PUNCT
cajgh-231	224	13	26	26	NUM
cajgh-231	224	14	.	.	PUNCT
cajgh-231	225	1	mandel	mandel	PROPN
cajgh-231	225	2	s	s	PROPN
cajgh-231	225	3	,	,	PUNCT
cajgh-231	225	4	grunblatt	grunblatt	ADJ
cajgh-231	225	5	e	e	NOUN
cajgh-231	225	6	,	,	PUNCT
cajgh-231	225	7	riederer	riederer	NOUN
cajgh-231	225	8	p	p	NOUN
cajgh-231	225	9	,	,	PUNCT
cajgh-231	225	10	et	et	PROPN
cajgh-231	225	11	al	al	PROPN
cajgh-231	225	12	.	.	PROPN
cajgh-231	225	13	gene	gene	NOUN
cajgh-231	225	14	expression	expression	NOUN
cajgh-231	225	15	profiling	profiling	NOUN
cajgh-231	225	16	of	of	ADP
cajgh-231	225	17	sporadic	sporadic	ADJ
cajgh-231	225	18	parkinson	parkinson	NOUN
cajgh-231	225	19	's	's	PART
cajgh-231	225	20	disease	disease	NOUN
cajgh-231	225	21	substantia	substantia	NOUN
cajgh-231	225	22	nigra	nigra	PROPN
cajgh-231	225	23	pars	par	NOUN
cajgh-231	225	24	compacta	compacta	PROPN
cajgh-231	225	25	reveals	reveal	VERB
cajgh-231	225	26	impairment	impairment	NOUN
cajgh-231	225	27	of	of	ADP
cajgh-231	225	28	ubiquitin	ubiquitin	ADJ
cajgh-231	225	29	-	-	PUNCT
cajgh-231	225	30	proteasome	proteasome	NOUN
cajgh-231	225	31	subunits	subunit	NOUN
cajgh-231	225	32	,	,	PUNCT
cajgh-231	225	33	skp1a	skp1a	NOUN
cajgh-231	225	34	,	,	PUNCT
cajgh-231	225	35	aldehyde	aldehyde	NOUN
cajgh-231	225	36	dehydrogenase	dehydrogenase	NOUN
cajgh-231	225	37	,	,	PUNCT
cajgh-231	225	38	and	and	CCONJ
cajgh-231	225	39	chaperone	chaperone	VERB
cajgh-231	225	40	hsc-70	hsc-70	PROPN
cajgh-231	225	41	.	.	PUNCT
cajgh-231	226	1	ann	ann	PROPN
cajgh-231	226	2	n	n	PROPN
cajgh-231	226	3	y	y	PROPN
cajgh-231	226	4	acad	acad	PROPN
cajgh-231	226	5	sci	sci	PROPN
cajgh-231	226	6	.	.	PUNCT
cajgh-231	227	1	vol	vol	NOUN
cajgh-231	227	2	10532008:356–375	10532008:356–375	INTJ
cajgh-231	227	3	.	.	PUNCT
cajgh-231	228	1	27	27	NUM
cajgh-231	228	2	.	.	PUNCT
cajgh-231	229	1	masliah	masliah	PROPN
cajgh-231	229	2	e	e	PROPN
cajgh-231	229	3	,	,	PUNCT
cajgh-231	229	4	w.	w.	PROPN
cajgh-231	229	5	dumaop	dumaop	PROPN
cajgh-231	229	6	dg	dg	PROPN
cajgh-231	229	7	,	,	PUNCT
cajgh-231	229	8	desplats	desplat	VERB
cajgh-231	229	9	p.	p.	NOUN
cajgh-231	229	10	distinctive	distinctive	ADJ
cajgh-231	229	11	patterns	pattern	NOUN
cajgh-231	229	12	of	of	ADP
cajgh-231	229	13	dna	dna	PROPN
cajgh-231	229	14	methylation	methylation	NOUN
cajgh-231	229	15	associated	associate	VERB
cajgh-231	229	16	with	with	ADP
cajgh-231	229	17	parkinson	parkinson	NOUN
cajgh-231	229	18	disease	disease	NOUN
cajgh-231	229	19	.	.	PUNCT
cajgh-231	230	1	epigenetics	epigenetic	NOUN
cajgh-231	230	2	.	.	PUNCT
cajgh-231	231	1	vol	vol	NOUN
cajgh-231	231	2	8	8	NUM
cajgh-231	231	3	(	(	PUNCT
cajgh-231	231	4	10)2013:1030	10)2013:1030	NUM
cajgh-231	231	5	-	-	NOUN
cajgh-231	231	6	1038	1038	NUM
cajgh-231	231	7	.	.	PUNCT
cajgh-231	232	1	28	28	NUM
cajgh-231	232	2	.	.	PUNCT
cajgh-231	233	1	lane	lane	PROPN
cajgh-231	233	2	n.	n.	PROPN
cajgh-231	233	3	a	a	DET
cajgh-231	233	4	unifying	unifying	ADJ
cajgh-231	233	5	view	view	NOUN
cajgh-231	233	6	of	of	ADP
cajgh-231	233	7	ageing	ageing	NOUN
cajgh-231	233	8	and	and	CCONJ
cajgh-231	233	9	disease	disease	NOUN
cajgh-231	233	10	:	:	PUNCT
cajgh-231	233	11	the	the	DET
cajgh-231	233	12	double	double	ADJ
cajgh-231	233	13	-	-	PUNCT
cajgh-231	233	14	agent	agent	NOUN
cajgh-231	233	15	theory	theory	NOUN
cajgh-231	233	16	.	.	PUNCT
cajgh-231	234	1	j	j	PROPN
cajgh-231	234	2	theor	theor	PROPN
cajgh-231	234	3	biol	biol	PROPN
cajgh-231	234	4	.	.	PUNCT
cajgh-231	235	1	vol	vol	NOUN
cajgh-231	235	2	225	225	NUM
cajgh-231	235	3	(	(	PUNCT
cajgh-231	235	4	4)2003:531	4)2003:531	NUM
cajgh-231	235	5	-	-	SYM
cajgh-231	235	6	540	540	NUM
cajgh-231	235	7	.	.	PUNCT
cajgh-231	235	8	29	29	NUM
cajgh-231	235	9	.	.	PUNCT
cajgh-231	236	1	murphy	murphy	PROPN
cajgh-231	236	2	mp	mp	PROPN
cajgh-231	236	3	.	.	PUNCT
cajgh-231	237	1	how	how	SCONJ
cajgh-231	237	2	mitochondria	mitochondria	PROPN
cajgh-231	237	3	produce	produce	VERB
cajgh-231	237	4	reactive	reactive	ADJ
cajgh-231	237	5	oxygen	oxygen	NOUN
cajgh-231	237	6	species	specie	NOUN
cajgh-231	237	7	.	.	PUNCT
cajgh-231	238	1	biochem	biochem	PROPN
cajgh-231	238	2	j.	j.	PROPN
cajgh-231	238	3	vol	vol	PROPN
cajgh-231	238	4	4172009:1	4172009:1	NUM
cajgh-231	238	5	-	-	SYM
cajgh-231	238	6	13	13	NUM
cajgh-231	238	7	.	.	PUNCT
cajgh-231	238	8	30	30	NUM
cajgh-231	238	9	.	.	PUNCT
cajgh-231	239	1	harmann	harmann	PROPN
cajgh-231	239	2	d.	d.	PROPN
cajgh-231	239	3	aging	age	VERB
cajgh-231	239	4	a	a	DET
cajgh-231	239	5	theory	theory	NOUN
cajgh-231	239	6	based	base	VERB
cajgh-231	239	7	on	on	ADP
cajgh-231	239	8	freeradical	freeradical	ADJ
cajgh-231	239	9	and	and	CCONJ
cajgh-231	239	10	radiation	radiation	NOUN
cajgh-231	239	11	chemistry	chemistry	NOUN
cajgh-231	239	12	.	.	PUNCT
cajgh-231	240	1	j	j	PROPN
cajgh-231	240	2	gerontol	gerontol	PROPN
cajgh-231	240	3	.	.	PUNCT
cajgh-231	241	1	vol	vol	NOUN
cajgh-231	241	2	111956:298	111956:298	NUM
cajgh-231	241	3	-	-	SYM
cajgh-231	241	4	300	300	NUM
cajgh-231	241	5	.	.	PUNCT
cajgh-231	241	6	31	31	NUM
cajgh-231	241	7	.	.	PUNCT
cajgh-231	242	1	barja	barja	PROPN
cajgh-231	242	2	g.	g.	PROPN
cajgh-231	242	3	updating	update	VERB
cajgh-231	242	4	the	the	DET
cajgh-231	242	5	mitochondrial	mitochondrial	ADJ
cajgh-231	242	6	freeradical	freeradical	ADJ
cajgh-231	242	7	theory	theory	NOUN
cajgh-231	242	8	of	of	ADP
cajgh-231	242	9	aging	aging	NOUN
cajgh-231	242	10	:	:	PUNCT
cajgh-231	242	11	an	an	DET
cajgh-231	242	12	integrated	integrated	ADJ
cajgh-231	242	13	view	view	NOUN
cajgh-231	242	14	,	,	PUNCT
cajgh-231	242	15	key	key	ADJ
cajgh-231	242	16	aspects	aspect	NOUN
cajgh-231	242	17	,	,	PUNCT
cajgh-231	242	18	and	and	CCONJ
cajgh-231	242	19	confounding	confound	VERB
cajgh-231	242	20	concepts	concept	NOUN
cajgh-231	242	21	.	.	PUNCT
cajgh-231	243	1	antioxid	antioxid	VERB
cajgh-231	243	2	redox	redox	NOUN
cajgh-231	243	3	signal	signal	NOUN
cajgh-231	243	4	.	.	PUNCT
cajgh-231	244	1	vol	vol	NOUN
cajgh-231	244	2	192013:1420	192013:1420	NUM
cajgh-231	244	3	-	-	SYM
cajgh-231	244	4	1445	1445	NUM
cajgh-231	244	5	.	.	PUNCT
cajgh-231	245	1	32	32	NUM
cajgh-231	245	2	.	.	PUNCT
cajgh-231	245	3	wiedemann	wiedemann	PROPN
cajgh-231	245	4	fr	fr	PROPN
cajgh-231	245	5	,	,	PUNCT
cajgh-231	245	6	winkler	winkler	PROPN
cajgh-231	245	7	k	k	PROPN
cajgh-231	245	8	,	,	PUNCT
cajgh-231	245	9	lins	lin	NOUN
cajgh-231	245	10	h	h	NOUN
cajgh-231	245	11	,	,	PUNCT
cajgh-231	245	12	wallesch	wallesch	ADJ
cajgh-231	245	13	c	c	NOUN
cajgh-231	245	14	-	-	PUNCT
cajgh-231	245	15	w	w	PROPN
cajgh-231	245	16	,	,	PUNCT
cajgh-231	245	17	kunz	kunz	PROPN
cajgh-231	245	18	ws	ws	PROPN
cajgh-231	245	19	.	.	PUNCT
cajgh-231	246	1	detection	detection	NOUN
cajgh-231	246	2	of	of	ADP
cajgh-231	246	3	respiratory	respiratory	ADJ
cajgh-231	246	4	chain	chain	NOUN
cajgh-231	246	5	defects	defect	NOUN
cajgh-231	246	6	in	in	ADP
cajgh-231	246	7	cultivated	cultivate	VERB
cajgh-231	246	8	skin	skin	NOUN
cajgh-231	246	9	fibroblasts	fibroblast	NOUN
cajgh-231	246	10	and	and	CCONJ
cajgh-231	246	11	skeletal	skeletal	ADJ
cajgh-231	246	12	muscle	muscle	NOUN
cajgh-231	246	13	of	of	ADP
cajgh-231	246	14	patients	patient	NOUN
cajgh-231	246	15	with	with	ADP
cajgh-231	246	16	parkinson	parkinson	NOUN
cajgh-231	246	17	's	's	PART
cajgh-231	246	18	disease	disease	NOUN
cajgh-231	246	19	.	.	PUNCT
cajgh-231	247	1	ann	ann	PROPN
cajgh-231	247	2	n	n	PROPN
cajgh-231	247	3	y	y	PROPN
cajgh-231	247	4	acad	acad	PROPN
cajgh-231	247	5	sci	sci	PROPN
cajgh-231	247	6	.	.	PUNCT
cajgh-231	248	1	vol	vol	NOUN
cajgh-231	248	2	8932006:426429	8932006:426429	NUM
cajgh-231	248	3	.	.	NOUN
cajgh-231	249	1	33	33	NUM
cajgh-231	249	2	.	.	PUNCT
cajgh-231	250	1	barroso	barroso	PROPN
cajgh-231	250	2	n	n	CCONJ
cajgh-231	250	3	,	,	PUNCT
cajgh-231	250	4	campos	campos	PROPN
cajgh-231	250	5	y	y	PROPN
cajgh-231	250	6	,	,	PUNCT
cajgh-231	250	7	huertas	huertas	PROPN
cajgh-231	250	8	r	r	PROPN
cajgh-231	250	9	,	,	PUNCT
cajgh-231	250	10	esteban	esteban	PROPN
cajgh-231	250	11	j	j	PROPN
cajgh-231	250	12	,	,	PUNCT
cajgh-231	250	13	molina	molina	PROPN
cajgh-231	250	14	ja	ja	PROPN
cajgh-231	250	15	.	.	PUNCT
cajgh-231	251	1	respiratory	respiratory	ADJ
cajgh-231	251	2	chain	chain	NOUN
cajgh-231	251	3	enzyme	enzyme	NOUN
cajgh-231	251	4	activities	activity	NOUN
cajgh-231	251	5	in	in	ADP
cajgh-231	251	6	lymphocytes	lymphocyte	NOUN
cajgh-231	251	7	from	from	ADP
cajgh-231	251	8	untreated	untreated	ADJ
cajgh-231	251	9	patients	patient	NOUN
cajgh-231	251	10	with	with	ADP
cajgh-231	251	11	parkinson	parkinson	NOUN
cajgh-231	251	12	disease	disease	NOUN
cajgh-231	251	13	.	.	PUNCT
cajgh-231	252	1	clin	clin	PROPN
cajgh-231	252	2	chem	chem	PROPN
cajgh-231	252	3	.	.	PUNCT
cajgh-231	253	1	vol	vol	NOUN
cajgh-231	253	2	391993:667	391993:667	NUM
cajgh-231	253	3	-	-	PUNCT
cajgh-231	253	4	669	669	NUM
cajgh-231	253	5	.	.	PUNCT
cajgh-231	254	1	34	34	NUM
cajgh-231	254	2	.	.	PUNCT
cajgh-231	254	3	yoshino	yoshino	PROPN
cajgh-231	254	4	h	h	PROPN
cajgh-231	254	5	,	,	PUNCT
cajgh-231	254	6	nakagawa	nakagawa	PROPN
cajgh-231	254	7	-	-	PUNCT
cajgh-231	254	8	hattori	hattori	PROPN
cajgh-231	254	9	y	y	PROPN
cajgh-231	254	10	,	,	PUNCT
cajgh-231	254	11	kondo	kondo	PROPN
cajgh-231	254	12	t	t	PROPN
cajgh-231	254	13	,	,	PUNCT
cajgh-231	254	14	mizuno	mizuno	PROPN
cajgh-231	254	15	y.	y.	PROPN
cajgh-231	254	16	mitochondrial	mitochondrial	PROPN
cajgh-231	254	17	complex	complex	NOUN
cajgh-231	254	18	i	i	PRON
cajgh-231	254	19	and	and	CCONJ
cajgh-231	254	20	ii	ii	NOUN
cajgh-231	254	21	activities	activity	NOUN
cajgh-231	254	22	of	of	ADP
cajgh-231	254	23	lymphocytes	lymphocyte	NOUN
cajgh-231	254	24	and	and	CCONJ
cajgh-231	254	25	platelets	platelet	NOUN
cajgh-231	254	26	in	in	ADP
cajgh-231	254	27	parkinson	parkinson	NOUN
cajgh-231	254	28	's	's	PART
cajgh-231	254	29	disease	disease	NOUN
cajgh-231	254	30	.	.	PUNCT
cajgh-231	255	1	j	j	PROPN
cajgh-231	255	2	neural	neural	ADJ
cajgh-231	255	3	transm	transm	PROPN
cajgh-231	255	4	vol	vol	NOUN
cajgh-231	255	5	4	4	NUM
cajgh-231	255	6	(	(	PUNCT
cajgh-231	255	7	1)1992:27	1)1992:27	NUM
cajgh-231	255	8	-	-	SYM
cajgh-231	255	9	34	34	NUM
cajgh-231	255	10	.	.	NOUN
cajgh-231	255	11	35	35	NUM
cajgh-231	255	12	.	.	PUNCT
cajgh-231	256	1	mytilineou	mytilineou	NOUN
cajgh-231	256	2	c	c	NOUN
cajgh-231	256	3	,	,	PUNCT
cajgh-231	256	4	werner	werner	PROPN
cajgh-231	256	5	p	p	PROPN
cajgh-231	256	6	,	,	PUNCT
cajgh-231	256	7	molinari	molinari	PROPN
cajgh-231	256	8	s	s	PROPN
cajgh-231	256	9	,	,	PUNCT
cajgh-231	256	10	rocco	rocco	NOUN
cajgh-231	256	11	ad	ad	NOUN
cajgh-231	256	12	,	,	PUNCT
cajgh-231	256	13	cohen	cohen	NOUN
cajgh-231	256	14	g	g	PROPN
cajgh-231	256	15	,	,	PUNCT
cajgh-231	256	16	yahr	yahr	PROPN
cajgh-231	256	17	md	md	PROPN
cajgh-231	256	18	.	.	PUNCT
cajgh-231	257	1	impaired	impair	VERB
cajgh-231	257	2	oxidative	oxidative	ADJ
cajgh-231	257	3	decarboxylation	decarboxylation	NOUN
cajgh-231	257	4	of	of	ADP
cajgh-231	257	5	pyruvate	pyruvate	NOUN
cajgh-231	257	6	in	in	ADP
cajgh-231	257	7	fibroblasts	fibroblast	NOUN
cajgh-231	257	8	from	from	ADP
cajgh-231	257	9	patients	patient	NOUN
cajgh-231	257	10	with	with	ADP
cajgh-231	257	11	parkinson	parkinson	NOUN
cajgh-231	257	12	's	's	PART
cajgh-231	257	13	disease	disease	NOUN
cajgh-231	257	14	.	.	PUNCT
cajgh-231	258	1	j	j	PROPN
cajgh-231	258	2	neural	neural	PROPN
cajgh-231	258	3	transm	transm	PROPN
cajgh-231	258	4	.	.	PUNCT
cajgh-231	259	1	vol	vol	NOUN
cajgh-231	259	2	8	8	NUM
cajgh-231	259	3	(	(	PUNCT
cajgh-231	259	4	3)1994:223	3)1994:223	NUM
cajgh-231	259	5	-	-	SYM
cajgh-231	259	6	228	228	NUM
cajgh-231	259	7	.	.	PUNCT
cajgh-231	259	8	36	36	NUM
cajgh-231	259	9	.	.	PUNCT
cajgh-231	260	1	braak	braak	PROPN
cajgh-231	260	2	h	h	PROPN
cajgh-231	260	3	,	,	PUNCT
cajgh-231	260	4	tredici	tredici	PROPN
cajgh-231	260	5	kd	kd	PROPN
cajgh-231	260	6	,	,	PUNCT
cajgh-231	260	7	rüb	rüb	PROPN
cajgh-231	260	8	u	u	PROPN
cajgh-231	260	9	,	,	PUNCT
cajgh-231	260	10	vos	vos	PROPN
cajgh-231	260	11	raid	raid	NOUN
cajgh-231	260	12	,	,	PUNCT
cajgh-231	260	13	steur	steur	PROPN
cajgh-231	260	14	enhj	enhj	PROPN
cajgh-231	260	15	,	,	PUNCT
cajgh-231	260	16	braak	braak	PROPN
cajgh-231	260	17	e.	e.	PROPN
cajgh-231	260	18	staging	staging	NOUN
cajgh-231	260	19	of	of	ADP
cajgh-231	260	20	brain	brain	NOUN
cajgh-231	260	21	pathology	pathology	NOUN
cajgh-231	260	22	related	relate	VERB
cajgh-231	260	23	to	to	ADP
cajgh-231	260	24	sporadic	sporadic	ADJ
cajgh-231	260	25	parkinson	parkinson	NOUN
cajgh-231	260	26	’s	’s	PART
cajgh-231	260	27	disease	disease	NOUN
cajgh-231	260	28	.	.	PUNCT
cajgh-231	261	1	neurobiology	neurobiology	NOUN
cajgh-231	261	2	aging	aging	NOUN
cajgh-231	261	3	.	.	PUNCT
cajgh-231	262	1	vol	vol	NOUN
cajgh-231	262	2	242003:197–211	242003:197–211	NOUN
cajgh-231	262	3	.	.	PUNCT
cajgh-231	263	1	37	37	NUM
cajgh-231	263	2	.	.	PUNCT
cajgh-231	264	1	li	li	PROPN
cajgh-231	264	2	jy	jy	PROPN
cajgh-231	264	3	,	,	PUNCT
cajgh-231	264	4	englund	englund	PROPN
cajgh-231	264	5	e	e	PROPN
cajgh-231	264	6	,	,	PUNCT
cajgh-231	264	7	holton	holton	PROPN
cajgh-231	264	8	jl	jl	PROPN
cajgh-231	264	9	,	,	PUNCT
cajgh-231	264	10	et	et	PROPN
cajgh-231	264	11	al	al	PROPN
cajgh-231	264	12	.	.	PROPN
cajgh-231	265	1	lewy	lewy	PROPN
cajgh-231	265	2	bodies	body	NOUN
cajgh-231	265	3	in	in	ADP
cajgh-231	265	4	grafted	graft	VERB
cajgh-231	265	5	neurons	neuron	NOUN
cajgh-231	265	6	in	in	ADP
cajgh-231	265	7	subjects	subject	NOUN
cajgh-231	265	8	with	with	ADP
cajgh-231	265	9	parkinson	parkinson	NOUN
cajgh-231	265	10	's	's	PART
cajgh-231	265	11	disease	disease	NOUN
cajgh-231	265	12	suggest	suggest	VERB
cajgh-231	265	13	host	host	NOUN
cajgh-231	265	14	-	-	PUNCT
cajgh-231	265	15	to	to	ADP
cajgh-231	265	16	-	-	PUNCT
cajgh-231	265	17	graft	graft	NOUN
cajgh-231	265	18	disease	disease	NOUN
cajgh-231	265	19	propagation	propagation	NOUN
cajgh-231	265	20	.	.	PUNCT
cajgh-231	266	1	nat	nat	PROPN
cajgh-231	266	2	med	med	PROPN
cajgh-231	266	3	.	.	PUNCT
cajgh-231	267	1	vol	vol	NOUN
cajgh-231	267	2	142008:501	142008:501	NUM
cajgh-231	267	3	-	-	SYM
cajgh-231	267	4	503	503	NUM
cajgh-231	267	5	.	.	PUNCT
cajgh-231	267	6	38	38	NUM
cajgh-231	267	7	.	.	PUNCT
cajgh-231	268	1	kordower	kordower	PROPN
cajgh-231	268	2	jh	jh	PROPN
cajgh-231	268	3	,	,	PUNCT
cajgh-231	268	4	chun	chun	PROPN
cajgh-231	268	5	y	y	PROPN
cajgh-231	268	6	,	,	PUNCT
cajgh-231	268	7	hauser	hauser	PROPN
cajgh-231	268	8	ra	ra	PROPN
cajgh-231	268	9	,	,	PUNCT
cajgh-231	268	10	freeman	freeman	PROPN
cajgh-231	268	11	tb	tb	PROPN
cajgh-231	268	12	,	,	PUNCT
cajgh-231	268	13	olanow	olanow	ADV
cajgh-231	268	14	cw	cw	PROPN
cajgh-231	268	15	.	.	PROPN
cajgh-231	268	16	lewy	lewy	PROPN
cajgh-231	268	17	body	body	PROPN
cajgh-231	268	18	-	-	PUNCT
cajgh-231	268	19	like	like	ADJ
cajgh-231	268	20	pathology	pathology	NOUN
cajgh-231	268	21	in	in	ADP
cajgh-231	268	22	long	long	ADJ
cajgh-231	268	23	-	-	PUNCT
cajgh-231	268	24	term	term	NOUN
cajgh-231	268	25	embryonic	embryonic	ADJ
cajgh-231	268	26	nigral	nigral	ADJ
cajgh-231	268	27	transplants	transplant	NOUN
cajgh-231	268	28	in	in	ADP
cajgh-231	268	29	parkinson	parkinson	NOUN
cajgh-231	268	30	's	's	PART
cajgh-231	268	31	disease	disease	NOUN
cajgh-231	268	32	.	.	PUNCT
cajgh-231	269	1	nat	nat	PROPN
cajgh-231	269	2	med	med	PROPN
cajgh-231	269	3	.	.	PUNCT
cajgh-231	270	1	vol	vol	NOUN
cajgh-231	270	2	142008:504506	142008:504506	NUM
cajgh-231	270	3	.	.	PROPN
cajgh-231	271	1	39	39	NUM
cajgh-231	271	2	.	.	PUNCT
cajgh-231	272	1	valadi	valadi	PROPN
cajgh-231	272	2	h	h	PROPN
cajgh-231	272	3	,	,	PUNCT
cajgh-231	272	4	ekström	ekström	PROPN
cajgh-231	272	5	k	k	NOUN
cajgh-231	272	6	,	,	PUNCT
cajgh-231	272	7	bossios	bossio	VERB
cajgh-231	272	8	a	a	PRON
cajgh-231	272	9	,	,	PUNCT
cajgh-231	272	10	sjöstrand	sjöstrand	PROPN
cajgh-231	272	11	m	m	PROPN
cajgh-231	272	12	,	,	PUNCT
cajgh-231	272	13	lee	lee	PROPN
cajgh-231	272	14	jj	jj	PROPN
cajgh-231	272	15	.	.	PROPN
cajgh-231	272	16	exosome	exosome	PROPN
cajgh-231	272	17	-	-	PUNCT
cajgh-231	272	18	mediated	mediate	VERB
cajgh-231	272	19	transfer	transfer	NOUN
cajgh-231	272	20	of	of	ADP
cajgh-231	272	21	mrnas	mrna	NOUN
cajgh-231	272	22	and	and	CCONJ
cajgh-231	272	23	micrornas	microrna	NOUN
cajgh-231	272	24	is	be	AUX
cajgh-231	272	25	a	a	DET
cajgh-231	272	26	novel	novel	ADJ
cajgh-231	272	27	mechanism	mechanism	NOUN
cajgh-231	272	28	of	of	ADP
cajgh-231	272	29	genetic	genetic	ADJ
cajgh-231	272	30	exchange	exchange	NOUN
cajgh-231	272	31	between	between	ADP
cajgh-231	272	32	cells	cell	NOUN
cajgh-231	272	33	.	.	PUNCT
cajgh-231	273	1	nat	nat	NOUN
cajgh-231	273	2	cell	cell	NOUN
cajgh-231	273	3	biol	biol	PROPN
cajgh-231	273	4	.	.	PUNCT
cajgh-231	274	1	vol	vol	NOUN
cajgh-231	274	2	92007:654	92007:654	NUM
cajgh-231	274	3	659	659	NUM
cajgh-231	274	4	.	.	NUM
cajgh-231	274	5	40	40	NUM
cajgh-231	274	6	.	.	PUNCT
cajgh-231	275	1	tan	tan	PROPN
cajgh-231	275	2	as	as	ADP
cajgh-231	275	3	,	,	PUNCT
cajgh-231	275	4	baty	baty	PROPN
cajgh-231	275	5	jw	jw	PROPN
cajgh-231	275	6	,	,	PUNCT
cajgh-231	275	7	dong	dong	PROPN
cajgh-231	275	8	l	l	PROPN
cajgh-231	275	9	-	-	PROPN
cajgh-231	275	10	f	f	PROPN
cajgh-231	275	11	,	,	PUNCT
cajgh-231	275	12	et	et	PROPN
cajgh-231	275	13	al	al	PROPN
cajgh-231	275	14	.	.	PUNCT
cajgh-231	275	15	mitochondrial	mitochondrial	ADJ
cajgh-231	275	16	genome	genome	NOUN
cajgh-231	275	17	acquisition	acquisition	NOUN
cajgh-231	275	18	restores	restore	VERB
cajgh-231	275	19	respiratory	respiratory	ADJ
cajgh-231	275	20	function	function	NOUN
cajgh-231	275	21	and	and	CCONJ
cajgh-231	275	22	tumorigenic	tumorigenic	ADJ
cajgh-231	275	23	potential	potential	NOUN
cajgh-231	275	24	of	of	ADP
cajgh-231	275	25	cancer	cancer	NOUN
cajgh-231	275	26	cells	cell	NOUN
cajgh-231	275	27	without	without	ADP
cajgh-231	275	28	mitochondrial	mitochondrial	ADJ
cajgh-231	275	29	dna	dna	NOUN
cajgh-231	275	30	.	.	PUNCT
cajgh-231	276	1	cell	cell	NOUN
cajgh-231	276	2	metab	metab	NOUN
cajgh-231	276	3	.	.	PUNCT
cajgh-231	277	1	vol	vol	NOUN
cajgh-231	277	2	21	21	NUM
cajgh-231	277	3	(	(	PUNCT
cajgh-231	277	4	1)2015:81	1)2015:81	NUM
cajgh-231	277	5	-	-	SYM
cajgh-231	277	6	94	94	NUM
cajgh-231	277	7	.	.	PUNCT
cajgh-231	277	8	41	41	NUM
cajgh-231	277	9	.	.	PUNCT
cajgh-231	278	1	jayaprakash	jayaprakash	ADJ
cajgh-231	278	2	ad	ad	NOUN
cajgh-231	278	3	,	,	PUNCT
cajgh-231	278	4	benson	benson	PROPN
cajgh-231	278	5	ek	ek	PROPN
cajgh-231	278	6	,	,	PUNCT
cajgh-231	278	7	gone	go	VERB
cajgh-231	278	8	s	s	PROPN
cajgh-231	278	9	,	,	PUNCT
cajgh-231	278	10	et	et	PROPN
cajgh-231	278	11	al	al	PROPN
cajgh-231	278	12	.	.	PROPN
cajgh-231	278	13	stable	stable	PROPN
cajgh-231	278	14	heteroplasmy	heteroplasmy	NOUN
cajgh-231	278	15	at	at	ADP
cajgh-231	278	16	the	the	DET
cajgh-231	278	17	single	single	ADJ
cajgh-231	278	18	-	-	PUNCT
cajgh-231	278	19	cell	cell	NOUN
cajgh-231	278	20	level	level	NOUN
cajgh-231	278	21	is	be	AUX
cajgh-231	278	22	facilitated	facilitate	VERB
cajgh-231	278	23	by	by	ADP
cajgh-231	278	24	intercellular	intercellular	ADJ
cajgh-231	278	25	exchange	exchange	NOUN
cajgh-231	278	26	of	of	ADP
cajgh-231	278	27	mtdna	mtdna	PROPN
cajgh-231	278	28	.	.	PUNCT
cajgh-231	279	1	nucleic	nucleic	ADJ
cajgh-231	279	2	acids	acid	NOUN
cajgh-231	279	3	res	re	NOUN
cajgh-231	279	4	.	.	PUNCT
cajgh-231	280	1	vol	vol	NOUN
cajgh-231	280	2	43	43	NUM
cajgh-231	280	3	(	(	PUNCT
cajgh-231	280	4	4)2015:2177	4)2015:2177	NUM
cajgh-231	280	5	-	-	NOUN
cajgh-231	280	6	2187	2187	NUM
cajgh-231	280	7	.	.	PUNCT
cajgh-231	281	1	42	42	NUM
cajgh-231	281	2	.	.	PUNCT
cajgh-231	282	1	trimmer	trimmer	PROPN
cajgh-231	282	2	pa	pa	PROPN
cajgh-231	282	3	,	,	PUNCT
cajgh-231	282	4	borland	borland	PROPN
cajgh-231	282	5	mk	mk	PROPN
cajgh-231	282	6	,	,	PUNCT
cajgh-231	282	7	keeney	keeney	PROPN
cajgh-231	282	8	pm	pm	PROPN
cajgh-231	282	9	,	,	PUNCT
cajgh-231	282	10	jr	jr	PROPN
cajgh-231	282	11	.	.	PROPN
cajgh-231	282	12	jpb	jpb	PROPN
cajgh-231	282	13	,	,	PUNCT
cajgh-231	282	14	jr	jr	PROPN
cajgh-231	282	15	.	.	PROPN
cajgh-231	283	1	wdp	wdp	PROPN
cajgh-231	283	2	.	.	PUNCT
cajgh-231	284	1	parkinson	parkinson	PROPN
cajgh-231	284	2	's	's	PART
cajgh-231	284	3	disease	disease	NOUN
cajgh-231	284	4	transgenic	transgenic	VERB
cajgh-231	284	5	mitochondrial	mitochondrial	ADJ
cajgh-231	284	6	cybrids	cybrid	NOUN
cajgh-231	284	7	generate	generate	VERB
cajgh-231	284	8	lewy	lewy	PROPN
cajgh-231	284	9	inclusion	inclusion	NOUN
cajgh-231	284	10	bodies	body	NOUN
cajgh-231	284	11	.	.	PUNCT
cajgh-231	285	1	vol	vol	NOUN
cajgh-231	285	2	882004:800	882004:800	NUM
cajgh-231	285	3	-	-	SYM
cajgh-231	285	4	812	812	NUM
cajgh-231	285	5	.	.	NOUN
cajgh-231	286	1	43	43	NUM
cajgh-231	286	2	.	.	PUNCT
cajgh-231	287	1	esteves	esteves	PROPN
cajgh-231	287	2	ar	ar	PROPN
cajgh-231	287	3	,	,	PUNCT
cajgh-231	287	4	domingues	domingue	NOUN
cajgh-231	287	5	af	af	PROPN
cajgh-231	287	6	,	,	PUNCT
cajgh-231	287	7	ferreira	ferreira	PROPN
cajgh-231	287	8	il	il	PROPN
cajgh-231	287	9	,	,	PUNCT
cajgh-231	287	10	et	et	PROPN
cajgh-231	287	11	al	al	PROPN
cajgh-231	287	12	.	.	PROPN
cajgh-231	287	13	mitochondrial	mitochondrial	ADJ
cajgh-231	287	14	function	function	NOUN
cajgh-231	287	15	in	in	ADP
cajgh-231	287	16	parkinson	parkinson	NOUN
cajgh-231	287	17	's	's	PART
cajgh-231	287	18	disease	disease	NOUN
cajgh-231	287	19	cybrids	cybrid	NOUN
cajgh-231	287	20	containing	contain	VERB
cajgh-231	287	21	an	an	DET
cajgh-231	287	22	nt2	nt2	NOUN
cajgh-231	287	23	neuron	neuron	NOUN
cajgh-231	287	24	-	-	PUNCT
cajgh-231	287	25	like	like	ADJ
cajgh-231	287	26	nuclear	nuclear	ADJ
cajgh-231	287	27	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	287	28	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	287	29	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	288	1	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	NUM
cajgh-231	288	2	central	central	ADJ
cajgh-231	288	3	asian	asian	ADJ
cajgh-231	288	4	journal	journal	NOUN
cajgh-231	288	5	of	of	ADP
cajgh-231	288	6	global	global	ADJ
cajgh-231	288	7	health	health	NOUN
cajgh-231	288	8	this	this	DET
cajgh-231	288	9	work	work	NOUN
cajgh-231	288	10	is	be	AUX
cajgh-231	288	11	licensed	license	VERB
cajgh-231	288	12	under	under	ADP
cajgh-231	288	13	a	a	DET
cajgh-231	288	14	creative	creative	ADJ
cajgh-231	288	15	commons	common	NOUN
cajgh-231	288	16	attribution	attribution	NOUN
cajgh-231	288	17	4.0	4.0	NUM
cajgh-231	288	18	united	unite	VERB
cajgh-231	288	19	states	states	PROPN
cajgh-231	288	20	license	license	NOUN
cajgh-231	288	21	.	.	PUNCT
cajgh-231	289	1	this	this	DET
cajgh-231	289	2	journal	journal	NOUN
cajgh-231	289	3	is	be	AUX
cajgh-231	289	4	published	publish	VERB
cajgh-231	289	5	by	by	ADP
cajgh-231	289	6	theuniversity	theuniversity	NOUN
cajgh-231	289	7	library	library	NOUN
cajgh-231	289	8	system	system	NOUN
cajgh-231	289	9	of	of	ADP
cajgh-231	289	10	the	the	DET
cajgh-231	289	11	university	university	PROPN
cajgh-231	289	12	of	of	ADP
cajgh-231	289	13	pittsburgh	pittsburgh	PROPN
cajgh-231	289	14	as	as	ADP
cajgh-231	289	15	part	part	NOUN
cajgh-231	289	16	of	of	ADP
cajgh-231	289	17	its	its	PRON
cajgh-231	289	18	d	d	NOUN
cajgh-231	289	19	-	-	PUNCT
cajgh-231	289	20	scribe	scribe	VERB
cajgh-231	289	21	digital	digital	ADJ
cajgh-231	289	22	publishing	publishing	NOUN
cajgh-231	289	23	program	program	NOUN
cajgh-231	289	24	and	and	CCONJ
cajgh-231	289	25	is	be	AUX
cajgh-231	289	26	cosponsored	cosponsor	VERB
cajgh-231	289	27	by	by	ADP
cajgh-231	289	28	the	the	DET
cajgh-231	289	29	university	university	PROPN
cajgh-231	289	30	of	of	ADP
cajgh-231	289	31	pittsburgh	pittsburgh	PROPN
cajgh-231	289	32	press	press	NOUN
cajgh-231	289	33	.	.	PUNCT
cajgh-231	290	1	central	central	ADJ
cajgh-231	290	2	asian	asian	ADJ
cajgh-231	290	3	journal	journal	NOUN
cajgh-231	290	4	of	of	ADP
cajgh-231	290	5	global	global	ADJ
cajgh-231	290	6	health	health	NOUN
cajgh-231	290	7	volume	volume	NOUN
cajgh-231	290	8	4	4	NUM
cajgh-231	290	9	,	,	PUNCT
cajgh-231	290	10	no	no	INTJ
cajgh-231	290	11	.	.	NOUN
cajgh-231	290	12	1	1	NUM
cajgh-231	290	13	(	(	PUNCT
cajgh-231	290	14	2015	2015	NUM
cajgh-231	290	15	)	)	PUNCT
cajgh-231	290	16	|	|	ADV
cajgh-231	290	17	issn	issn	VERB
cajgh-231	290	18	2166	2166	NUM
cajgh-231	290	19	-	-	SYM
cajgh-231	290	20	7403	7403	NUM
cajgh-231	290	21	(	(	PUNCT
cajgh-231	290	22	online	online	ADJ
cajgh-231	290	23	)	)	PUNCT
cajgh-231	290	24	|	|	ADV
cajgh-231	290	25	doi	doi	X
cajgh-231	290	26	10.5195	10.5195	NUM
cajgh-231	290	27	/	/	SYM
cajgh-231	290	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	290	29	background	background	NOUN
cajgh-231	290	30	.	.	PUNCT
cajgh-231	291	1	mitochondrion	mitochondrion	NOUN
cajgh-231	291	2	.	.	PUNCT
cajgh-231	292	1	vol	vol	NOUN
cajgh-231	292	2	82008:219228	82008:219228	NUM
cajgh-231	292	3	.	.	PROPN
cajgh-231	292	4	44	44	NUM
cajgh-231	292	5	.	.	PUNCT
cajgh-231	293	1	smiraglia	smiraglia	PROPN
cajgh-231	293	2	dj	dj	PROPN
cajgh-231	293	3	,	,	PUNCT
cajgh-231	293	4	kulawiec	kulawiec	PROPN
cajgh-231	293	5	m	m	PROPN
cajgh-231	293	6	,	,	PUNCT
cajgh-231	293	7	bistulfi	bistulfi	PROPN
cajgh-231	293	8	gl	gl	PROPN
cajgh-231	293	9	,	,	PUNCT
cajgh-231	293	10	gupta	gupta	PROPN
cajgh-231	293	11	sg	sg	PROPN
cajgh-231	293	12	,	,	PUNCT
cajgh-231	293	13	singh	singh	PROPN
cajgh-231	293	14	kk	kk	PROPN
cajgh-231	293	15	.	.	PUNCT
cajgh-231	294	1	a	a	DET
cajgh-231	294	2	novel	novel	ADJ
cajgh-231	294	3	role	role	NOUN
cajgh-231	294	4	for	for	ADP
cajgh-231	294	5	mitochondria	mitochondria	NOUN
cajgh-231	294	6	in	in	ADP
cajgh-231	294	7	regulating	regulate	VERB
cajgh-231	294	8	epigenetic	epigenetic	ADJ
cajgh-231	294	9	modification	modification	NOUN
cajgh-231	294	10	in	in	ADP
cajgh-231	294	11	the	the	DET
cajgh-231	294	12	nucleus	nucleus	NOUN
cajgh-231	294	13	.	.	PUNCT
cajgh-231	295	1	cener	cener	PROPN
cajgh-231	295	2	biol	biol	PROPN
cajgh-231	295	3	ther	ther	ADV
cajgh-231	295	4	.	.	PUNCT
cajgh-231	296	1	vol	vol	NOUN
cajgh-231	297	1	72008:11821190	72008:11821190	NUM
cajgh-231	297	2	.	.	NOUN
cajgh-231	298	1	45	45	NUM
cajgh-231	298	2	.	.	PUNCT
cajgh-231	299	1	xie	xie	PROPN
cajgh-231	299	2	ch	ch	PROPN
cajgh-231	299	3	,	,	PUNCT
cajgh-231	299	4	naito	naito	PROPN
cajgh-231	299	5	a	a	PROPN
cajgh-231	299	6	,	,	PUNCT
cajgh-231	299	7	mizumachi	mizumachi	NOUN
cajgh-231	299	8	t	t	PROPN
cajgh-231	299	9	,	,	PUNCT
cajgh-231	299	10	evans	evans	PROPN
cajgh-231	299	11	tt	tt	PROPN
cajgh-231	299	12	,	,	PUNCT
cajgh-231	299	13	douglas	douglas	PROPN
cajgh-231	299	14	mg	mg	PROPN
cajgh-231	299	15	,	,	PUNCT
cajgh-231	299	16	cooney	cooney	PROPN
cajgh-231	299	17	ca	can	AUX
cajgh-231	299	18	.	.	PUNCT
cajgh-231	300	1	mitochondrial	mitochondrial	ADJ
cajgh-231	300	2	regulation	regulation	NOUN
cajgh-231	300	3	of	of	ADP
cajgh-231	300	4	cancer	cancer	NOUN
cajgh-231	300	5	associated	associate	VERB
cajgh-231	300	6	nuclear	nuclear	ADJ
cajgh-231	300	7	dna	dna	PROPN
cajgh-231	300	8	methylation	methylation	NOUN
cajgh-231	300	9	.	.	PUNCT
cajgh-231	301	1	biochem	biochem	PROPN
cajgh-231	301	2	biophys	biophy	VERB
cajgh-231	301	3	res	re	NOUN
cajgh-231	301	4	commun	commun	PROPN
cajgh-231	301	5	.	.	PUNCT
cajgh-231	302	1	vol	vol	NOUN
cajgh-231	302	2	656	656	NUM
cajgh-231	302	3	-	-	PUNCT
cajgh-231	302	4	6612007:364	6612007:364	NUM
cajgh-231	302	5	.	.	PUNCT
cajgh-231	303	1	46	46	NUM
cajgh-231	303	2	.	.	PUNCT
cajgh-231	304	1	bellizzi	bellizzi	NOUN
cajgh-231	304	2	d	d	PROPN
cajgh-231	304	3	,	,	PUNCT
cajgh-231	304	4	d'aquila	d'aquila	PROPN
cajgh-231	304	5	p	p	NOUN
cajgh-231	304	6	,	,	PUNCT
cajgh-231	304	7	giordano	giordano	PROPN
cajgh-231	304	8	m	m	PROPN
cajgh-231	304	9	,	,	PUNCT
cajgh-231	304	10	montesanto	montesanto	ADP
cajgh-231	304	11	a	a	PRON
cajgh-231	304	12	,	,	PUNCT
cajgh-231	304	13	passarino	passarino	NOUN
cajgh-231	304	14	g.	g.	PROPN
cajgh-231	304	15	global	global	PROPN
cajgh-231	304	16	dna	dna	PROPN
cajgh-231	304	17	methylation	methylation	NOUN
cajgh-231	304	18	levels	level	NOUN
cajgh-231	304	19	are	be	AUX
cajgh-231	304	20	modulated	modulate	VERB
cajgh-231	304	21	by	by	ADP
cajgh-231	304	22	mitochondrial	mitochondrial	ADJ
cajgh-231	304	23	dna	dna	NOUN
cajgh-231	304	24	variants	variant	NOUN
cajgh-231	304	25	.	.	PUNCT
cajgh-231	305	1	epigenomics	epigenomic	NOUN
cajgh-231	305	2	.	.	PUNCT
cajgh-231	306	1	vol	vol	NOUN
cajgh-231	306	2	42012:17	42012:17	NUM
cajgh-231	306	3	-	-	PUNCT
cajgh-231	306	4	27	27	NUM
cajgh-231	306	5	.	.	PUNCT
cajgh-231	307	1	47	47	NUM
cajgh-231	307	2	.	.	PUNCT
cajgh-231	308	1	kelly	kelly	PROPN
cajgh-231	308	2	rd	rd	PROPN
cajgh-231	308	3	,	,	PUNCT
cajgh-231	308	4	rodda	rodda	PROPN
cajgh-231	308	5	ae	ae	PROPN
cajgh-231	308	6	,	,	PUNCT
cajgh-231	308	7	dickinson	dickinson	PROPN
cajgh-231	308	8	a	a	PROPN
cajgh-231	308	9	,	,	PUNCT
cajgh-231	308	10	et	et	PROPN
cajgh-231	308	11	al	al	PROPN
cajgh-231	308	12	.	.	PROPN
cajgh-231	308	13	mitochondrial	mitochondrial	ADJ
cajgh-231	308	14	dna	dna	PROPN
cajgh-231	308	15	haplotypes	haplotype	NOUN
cajgh-231	308	16	define	define	VERB
cajgh-231	308	17	gene	gene	NOUN
cajgh-231	308	18	expression	expression	NOUN
cajgh-231	308	19	patterns	pattern	NOUN
cajgh-231	308	20	in	in	ADP
cajgh-231	308	21	pluripotent	pluripotent	NOUN
cajgh-231	308	22	and	and	CCONJ
cajgh-231	308	23	differentiating	differentiate	VERB
cajgh-231	308	24	emrbyonic	emrbyonic	NOUN
cajgh-231	308	25	stem	stem	NOUN
cajgh-231	308	26	cells	cell	NOUN
cajgh-231	308	27	.	.	PUNCT
cajgh-231	309	1	stem	stem	NOUN
cajgh-231	309	2	cells	cell	NOUN
cajgh-231	309	3	.	.	PUNCT
cajgh-231	310	1	vol	vol	NOUN
cajgh-231	310	2	312013:703	312013:703	NUM
cajgh-231	310	3	-	-	SYM
cajgh-231	310	4	716	716	NUM
cajgh-231	310	5	.	.	X
cajgh-231	311	1	48	48	NUM
cajgh-231	311	2	.	.	PUNCT
cajgh-231	311	3	schapira	schapira	PROPN
cajgh-231	311	4	ahv	ahv	PROPN
cajgh-231	311	5	.	.	PROPN
cajgh-231	311	6	mitochondria	mitochondria	PROPN
cajgh-231	311	7	in	in	ADP
cajgh-231	311	8	the	the	DET
cajgh-231	311	9	aetiology	aetiology	NOUN
cajgh-231	311	10	and	and	CCONJ
cajgh-231	311	11	pathogenesis	pathogenesis	NOUN
cajgh-231	311	12	of	of	ADP
cajgh-231	311	13	parkinson	parkinson	NOUN
cajgh-231	311	14	's	's	PART
cajgh-231	311	15	disease	disease	NOUN
cajgh-231	311	16	.	.	PUNCT
cajgh-231	312	1	lancet	lancet	PROPN
cajgh-231	312	2	neurol	neurol	PROPN
cajgh-231	312	3	.	.	PUNCT
cajgh-231	313	1	vol	vol	NOUN
cajgh-231	313	2	72008:97	72008:97	NUM
cajgh-231	313	3	-	-	SYM
cajgh-231	313	4	109	109	NUM
cajgh-231	313	5	.	.	NUM
cajgh-231	313	6	49	49	NUM
cajgh-231	313	7	.	.	PUNCT
cajgh-231	314	1	maresca	maresca	PROPN
cajgh-231	314	2	a	a	PRON
cajgh-231	314	3	,	,	PUNCT
cajgh-231	314	4	zaffagnini	zaffagnini	PROPN
cajgh-231	314	5	m	m	PROPN
cajgh-231	314	6	,	,	PUNCT
cajgh-231	314	7	caporali	caporali	PROPN
cajgh-231	314	8	l	l	PROPN
cajgh-231	314	9	,	,	PUNCT
cajgh-231	314	10	carelli	carelli	PROPN
cajgh-231	314	11	v	v	PROPN
cajgh-231	314	12	,	,	PUNCT
cajgh-231	314	13	zanna	zanna	PROPN
cajgh-231	314	14	c.	c.	PROPN
cajgh-231	314	15	dna	dna	PROPN
cajgh-231	314	16	methyltransferase	methyltransferase	NOUN
cajgh-231	314	17	1	1	NUM
cajgh-231	314	18	mutations	mutation	NOUN
cajgh-231	314	19	and	and	CCONJ
cajgh-231	314	20	mitochondrial	mitochondrial	ADJ
cajgh-231	314	21	pathology	pathology	NOUN
cajgh-231	314	22	:	:	PUNCT
cajgh-231	314	23	is	be	AUX
cajgh-231	314	24	mtdna	mtdna	ADV
cajgh-231	314	25	methylated	methylate	VERB
cajgh-231	314	26	?	?	PUNCT
cajgh-231	315	1	front	front	ADJ
cajgh-231	315	2	genet	genet	NOUN
cajgh-231	315	3	.	.	PUNCT
cajgh-231	316	1	vol	vol	NOUN
cajgh-231	316	2	6	6	NUM
cajgh-231	316	3	art	art	NOUN
cajgh-231	316	4	.	.	PUNCT
cajgh-231	317	1	no	no	INTJ
cajgh-231	317	2	.	.	NOUN
cajgh-231	318	1	92015	92015	NUM
cajgh-231	318	2	.	.	PUNCT
cajgh-231	319	1	50	50	NUM
cajgh-231	319	2	.	.	PUNCT
cajgh-231	320	1	ghosh	ghosh	PROPN
cajgh-231	320	2	s	s	PROPN
cajgh-231	320	3	,	,	PUNCT
cajgh-231	320	4	singh	singh	PROPN
cajgh-231	320	5	kk	kk	PROPN
cajgh-231	320	6	,	,	PUNCT
cajgh-231	320	7	sengupta	sengupta	PROPN
cajgh-231	320	8	s	s	PROPN
cajgh-231	320	9	,	,	PUNCT
cajgh-231	320	10	scaria	scaria	PROPN
cajgh-231	320	11	v.	v.	PROPN
cajgh-231	320	12	mitoepigenetics	mitoepigenetic	NOUN
cajgh-231	320	13	:	:	PUNCT
cajgh-231	320	14	the	the	DET
cajgh-231	320	15	different	different	ADJ
cajgh-231	320	16	shades	shade	NOUN
cajgh-231	320	17	of	of	ADP
cajgh-231	320	18	grey	grey	ADJ
cajgh-231	320	19	.	.	PUNCT
cajgh-231	321	1	mitochondrion	mitochondrion	NOUN
cajgh-231	321	2	.	.	PUNCT
cajgh-231	322	1	vol	vol	NOUN
cajgh-231	322	2	252015:60	252015:60	NUM
cajgh-231	322	3	-	-	SYM
cajgh-231	322	4	66	66	NUM
cajgh-231	322	5	.	.	PUNCT
cajgh-231	323	1	51	51	NUM
cajgh-231	323	2	.	.	PUNCT
cajgh-231	324	1	hong	hong	PROPN
cajgh-231	324	2	ee	ee	PROPN
cajgh-231	324	3	,	,	PUNCT
cajgh-231	324	4	okitsu	okitsu	PROPN
cajgh-231	324	5	cy	cy	PROPN
cajgh-231	324	6	,	,	PUNCT
cajgh-231	324	7	smith	smith	PROPN
cajgh-231	324	8	ad	ad	NOUN
cajgh-231	324	9	,	,	PUNCT
cajgh-231	324	10	hsieh	hsieh	PROPN
cajgh-231	324	11	c	c	PROPN
cajgh-231	324	12	-	-	PUNCT
cajgh-231	324	13	l.	l.	NOUN
cajgh-231	324	14	regionally	regionally	ADV
cajgh-231	324	15	specific	specific	ADJ
cajgh-231	324	16	and	and	CCONJ
cajgh-231	324	17	genome	genome	NOUN
cajgh-231	324	18	-	-	PUNCT
cajgh-231	324	19	wide	wide	ADJ
cajgh-231	324	20	analyses	analysis	NOUN
cajgh-231	324	21	conclusively	conclusively	ADV
cajgh-231	324	22	demonstrate	demonstrate	VERB
cajgh-231	324	23	the	the	DET
cajgh-231	324	24	absence	absence	NOUN
cajgh-231	324	25	of	of	ADP
cajgh-231	324	26	cpg	cpg	NOUN
cajgh-231	324	27	methylation	methylation	NOUN
cajgh-231	324	28	in	in	ADP
cajgh-231	324	29	humann	humann	PROPN
cajgh-231	324	30	mitochondrial	mitochondrial	ADJ
cajgh-231	324	31	dna	dna	NOUN
cajgh-231	324	32	.	.	PUNCT
cajgh-231	325	1	mol	mol	ADP
cajgh-231	325	2	cell	cell	NOUN
cajgh-231	325	3	biol	biol	PROPN
cajgh-231	325	4	.	.	PUNCT
cajgh-231	326	1	vol	vol	NOUN
cajgh-231	326	2	33	33	NUM
cajgh-231	326	3	(	(	PUNCT
cajgh-231	326	4	14)2013:2683	14)2013:2683	PROPN
cajgh-231	326	5	-	-	SYM
cajgh-231	326	6	2690	2690	NUM
cajgh-231	326	7	.	.	PUNCT
cajgh-231	327	1	52	52	NUM
cajgh-231	327	2	.	.	PUNCT
cajgh-231	328	1	bacarelli	bacarelli	PROPN
cajgh-231	328	2	aa	aa	PROPN
cajgh-231	328	3	,	,	PUNCT
cajgh-231	328	4	byun	byun	NOUN
cajgh-231	328	5	h	h	NOUN
cajgh-231	328	6	-	-	PUNCT
cajgh-231	328	7	m.	m.	NOUN
cajgh-231	328	8	platelet	platelet	NOUN
cajgh-231	328	9	mitochondrial	mitochondrial	ADJ
cajgh-231	328	10	dna	dna	NOUN
cajgh-231	328	11	methylation	methylation	NOUN
cajgh-231	328	12	:	:	PUNCT
cajgh-231	328	13	a	a	DET
cajgh-231	328	14	potential	potential	ADJ
cajgh-231	328	15	new	new	ADJ
cajgh-231	328	16	marker	marker	NOUN
cajgh-231	328	17	of	of	ADP
cajgh-231	328	18	cardiovascular	cardiovascular	ADJ
cajgh-231	328	19	disease	disease	NOUN
cajgh-231	328	20	.	.	PUNCT
cajgh-231	329	1	clinical	clinical	ADJ
cajgh-231	329	2	epigenetics	epigenetic	NOUN
cajgh-231	329	3	.	.	PUNCT
cajgh-231	330	1	vol	vol	NOUN
cajgh-231	330	2	7	7	NUM
cajgh-231	330	3	(	(	PUNCT
cajgh-231	330	4	44)2015	44)2015	ADV
cajgh-231	330	5	.	.	PUNCT
cajgh-231	331	1	53	53	NUM
cajgh-231	331	2	.	.	PUNCT
cajgh-231	332	1	stuart	stuart	PROPN
cajgh-231	332	2	mj	mj	PROPN
cajgh-231	332	3	,	,	PUNCT
cajgh-231	332	4	murphy	murphy	PROPN
cajgh-231	332	5	s	s	PROPN
cajgh-231	332	6	,	,	PUNCT
cajgh-231	332	7	oski	oski	PROPN
cajgh-231	332	8	fa	fa	PROPN
cajgh-231	332	9	.	.	PUNCT
cajgh-231	333	1	a	a	DET
cajgh-231	333	2	simple	simple	ADJ
cajgh-231	333	3	nonradioisotope	nonradioisotope	ADJ
cajgh-231	333	4	technic	technic	NOUN
cajgh-231	333	5	for	for	ADP
cajgh-231	333	6	the	the	DET
cajgh-231	333	7	determination	determination	NOUN
cajgh-231	333	8	of	of	ADP
cajgh-231	333	9	platelet	platelet	NOUN
cajgh-231	333	10	life	life	NOUN
cajgh-231	333	11	-	-	PUNCT
cajgh-231	333	12	span	span	NOUN
cajgh-231	333	13	.	.	PUNCT
cajgh-231	334	1	n	n	PROPN
cajgh-231	334	2	engl	engl	PROPN
cajgh-231	334	3	j	j	PROPN
cajgh-231	334	4	med	med	PROPN
cajgh-231	334	5	.	.	PUNCT
cajgh-231	335	1	vol	vol	NOUN
cajgh-231	335	2	2921975:1310	2921975:1310	NUM
cajgh-231	335	3	-	-	SYM
cajgh-231	335	4	1313	1313	NUM
cajgh-231	335	5	.	.	PUNCT
cajgh-231	336	1	54	54	NUM
cajgh-231	336	2	.	.	PUNCT
cajgh-231	337	1	simon	simon	PROPN
cajgh-231	337	2	si	si	PROPN
cajgh-231	337	3	,	,	PUNCT
cajgh-231	337	4	kim	kim	PROPN
cajgh-231	337	5	m	m	PROPN
cajgh-231	337	6	-	-	PROPN
cajgh-231	337	7	h.	h.	PROPN
cajgh-231	337	8	a	a	DET
cajgh-231	337	9	day	day	NOUN
cajgh-231	337	10	(	(	PUNCT
cajgh-231	337	11	or	or	CCONJ
cajgh-231	337	12	5	5	NUM
cajgh-231	337	13	)	)	PUNCT
cajgh-231	337	14	in	in	ADP
cajgh-231	337	15	a	a	DET
cajgh-231	337	16	neutrophil	neutrophil	NOUN
cajgh-231	337	17	's	's	PART
cajgh-231	337	18	life	life	NOUN
cajgh-231	337	19	.	.	PUNCT
cajgh-231	338	1	blood	blood	NOUN
cajgh-231	338	2	.	.	PUNCT
cajgh-231	339	1	vol	vol	NOUN
cajgh-231	339	2	116	116	NUM
cajgh-231	339	3	(	(	PUNCT
cajgh-231	339	4	4)2010:511	4)2010:511	NUM
cajgh-231	339	5	512	512	NUM
cajgh-231	339	6	.	.	PUNCT
cajgh-231	340	1	55	55	NUM
cajgh-231	340	2	.	.	PUNCT
cajgh-231	341	1	tough	tough	ADJ
cajgh-231	341	2	df	df	PROPN
cajgh-231	341	3	,	,	PUNCT
cajgh-231	341	4	sprent	sprent	ADJ
cajgh-231	341	5	j.	j.	PROPN
cajgh-231	341	6	lifespan	lifespan	PROPN
cajgh-231	341	7	of	of	ADP
cajgh-231	341	8	lymphocytes	lymphocyte	NOUN
cajgh-231	341	9	.	.	PUNCT
cajgh-231	342	1	immunol	immunol	NOUN
cajgh-231	342	2	res	re	NOUN
cajgh-231	342	3	.	.	PUNCT
cajgh-231	343	1	vol	vol	NOUN
cajgh-231	343	2	14	14	NUM
cajgh-231	343	3	(	(	PUNCT
cajgh-231	343	4	1)1995:1	1)1995:1	NUM
cajgh-231	343	5	-	-	SYM
cajgh-231	343	6	12	12	NUM
cajgh-231	343	7	.	.	PUNCT
cajgh-231	343	8	56	56	NUM
cajgh-231	343	9	.	.	PUNCT
cajgh-231	344	1	chambers	chambers	PROPN
cajgh-231	344	2	sm	sm	PROPN
cajgh-231	344	3	,	,	PUNCT
cajgh-231	344	4	shaw	shaw	PROPN
cajgh-231	344	5	ca	ca	PROPN
cajgh-231	344	6	,	,	PUNCT
cajgh-231	344	7	gatza	gatza	NOUN
cajgh-231	344	8	c	c	PROPN
cajgh-231	344	9	,	,	PUNCT
cajgh-231	344	10	fisk	fisk	PROPN
cajgh-231	344	11	cj	cj	PROPN
cajgh-231	344	12	,	,	PUNCT
cajgh-231	344	13	donehower	donehower	NOUN
cajgh-231	344	14	la	la	PROPN
cajgh-231	344	15	,	,	PUNCT
cajgh-231	344	16	goodell	goodell	PROPN
cajgh-231	344	17	ma	ma	PROPN
cajgh-231	344	18	.	.	PROPN
cajgh-231	345	1	aging	age	VERB
cajgh-231	345	2	hematopoietic	hematopoietic	ADJ
cajgh-231	345	3	stem	stem	NOUN
cajgh-231	345	4	cells	cell	NOUN
cajgh-231	345	5	decline	decline	VERB
cajgh-231	345	6	in	in	ADP
cajgh-231	345	7	function	function	NOUN
cajgh-231	345	8	and	and	CCONJ
cajgh-231	345	9	exhibit	exhibit	VERB
cajgh-231	345	10	epigenetic	epigenetic	ADJ
cajgh-231	345	11	dysregulation	dysregulation	NOUN
cajgh-231	345	12	.	.	PUNCT
cajgh-231	346	1	plos	plos	PROPN
cajgh-231	346	2	biol	biol	PROPN
cajgh-231	346	3	.	.	PUNCT
cajgh-231	347	1	vol	vol	NOUN
cajgh-231	347	2	5	5	NUM
cajgh-231	347	3	(	(	PUNCT
cajgh-231	347	4	8)2007	8)2007	NUM
cajgh-231	347	5	:	:	PUNCT
cajgh-231	347	6	e201	e201	NUM
cajgh-231	347	7	.	.	PROPN
cajgh-231	347	8	57	57	NUM
cajgh-231	347	9	.	.	PUNCT
cajgh-231	348	1	rossi	rossi	PROPN
cajgh-231	348	2	dj	dj	PROPN
cajgh-231	348	3	,	,	PUNCT
cajgh-231	348	4	bryder	bryder	NOUN
cajgh-231	348	5	d	d	PROPN
cajgh-231	348	6	,	,	PUNCT
cajgh-231	348	7	zahn	zahn	PROPN
cajgh-231	348	8	jm	jm	PROPN
cajgh-231	348	9	,	,	PUNCT
cajgh-231	348	10	et	et	PROPN
cajgh-231	348	11	al	al	PROPN
cajgh-231	348	12	.	.	PROPN
cajgh-231	349	1	cell	cell	PROPN
cajgh-231	349	2	intrinsic	intrinsic	ADJ
cajgh-231	349	3	alterations	alteration	NOUN
cajgh-231	349	4	underlie	underlie	ADJ
cajgh-231	349	5	hematopoietic	hematopoietic	ADJ
cajgh-231	349	6	stem	stem	NOUN
cajgh-231	349	7	cell	cell	NOUN
cajgh-231	349	8	aging	aging	NOUN
cajgh-231	349	9	.	.	PUNCT
cajgh-231	350	1	proc	proc	PROPN
cajgh-231	350	2	natl	natl	PROPN
cajgh-231	350	3	acad	acad	PROPN
cajgh-231	350	4	sci	sci	PROPN
cajgh-231	350	5	usa	usa	PROPN
cajgh-231	350	6	.	.	PROPN
cajgh-231	350	7	vol	vol	NOUN
cajgh-231	350	8	1022005:9194	1022005:9194	NUM
cajgh-231	350	9	-	-	SYM
cajgh-231	350	10	9199	9199	NUM
cajgh-231	350	11	.	.	PUNCT
cajgh-231	351	1	58	58	NUM
cajgh-231	351	2	.	.	PUNCT
cajgh-231	352	1	hamanaka	hamanaka	PROPN
cajgh-231	352	2	rb	rb	PROPN
cajgh-231	352	3	,	,	PUNCT
cajgh-231	352	4	chandel	chandel	PROPN
cajgh-231	352	5	ns	n	VERB
cajgh-231	352	6	.	.	PUNCT
cajgh-231	353	1	mitochondrial	mitochondrial	ADJ
cajgh-231	353	2	reactive	reactive	ADJ
cajgh-231	353	3	oxygen	oxygen	NOUN
cajgh-231	353	4	species	specie	NOUN
cajgh-231	353	5	regulate	regulate	VERB
cajgh-231	353	6	cellular	cellular	ADJ
cajgh-231	353	7	signaling	signal	VERB
cajgh-231	353	8	and	and	CCONJ
cajgh-231	353	9	dictate	dictate	VERB
cajgh-231	353	10	biological	biological	ADJ
cajgh-231	353	11	outcomes	outcome	NOUN
cajgh-231	353	12	.	.	PUNCT
cajgh-231	354	1	trends	trend	NOUN
cajgh-231	354	2	biochem	biochem	PROPN
cajgh-231	354	3	sci	sci	PROPN
cajgh-231	354	4	.	.	PUNCT
cajgh-231	355	1	vol	vol	NOUN
cajgh-231	355	2	35	35	NUM
cajgh-231	355	3	(	(	PUNCT
cajgh-231	355	4	9)2010:505–513	9)2010:505–513	NUM
cajgh-231	355	5	.	.	PUNCT
cajgh-231	356	1	59	59	NUM
cajgh-231	356	2	.	.	PUNCT
cajgh-231	356	3	pervaiz	pervaiz	PROPN
cajgh-231	356	4	s	s	PROPN
cajgh-231	356	5	,	,	PUNCT
cajgh-231	356	6	taneja	taneja	NOUN
cajgh-231	356	7	r	r	NOUN
cajgh-231	356	8	,	,	PUNCT
cajgh-231	356	9	ghaffari	ghaffari	PROPN
cajgh-231	356	10	s.	s.	PROPN
cajgh-231	356	11	oxidative	oxidative	VERB
cajgh-231	356	12	stress	stress	NOUN
cajgh-231	356	13	regulation	regulation	NOUN
cajgh-231	356	14	of	of	ADP
cajgh-231	356	15	stem	stem	NOUN
cajgh-231	356	16	and	and	CCONJ
cajgh-231	356	17	progenitor	progenitor	NOUN
cajgh-231	356	18	cells	cell	NOUN
cajgh-231	356	19	.	.	PUNCT
cajgh-231	357	1	antioxid	antioxid	VERB
cajgh-231	357	2	redox	redox	NOUN
cajgh-231	357	3	signal	signal	NOUN
cajgh-231	357	4	.	.	PUNCT
cajgh-231	358	1	vol	vol	NOUN
cajgh-231	358	2	11(11)2009:27772789	11(11)2009:27772789	NUM
cajgh-231	358	3	.	.	PROPN
cajgh-231	358	4	60	60	NUM
cajgh-231	358	5	.	.	PUNCT
cajgh-231	359	1	francis	francis	PROPN
cajgh-231	359	2	r	r	PROPN
cajgh-231	359	3	,	,	PUNCT
cajgh-231	359	4	richardson	richardson	PROPN
cajgh-231	359	5	c.	c.	PROPN
cajgh-231	359	6	multipotent	multipotent	PROPN
cajgh-231	359	7	hematopoietic	hematopoietic	ADJ
cajgh-231	359	8	cells	cell	NOUN
cajgh-231	359	9	susceptible	susceptible	ADJ
cajgh-231	359	10	to	to	ADP
cajgh-231	359	11	alternative	alternative	ADJ
cajgh-231	359	12	double	double	ADJ
cajgh-231	359	13	-	-	PUNCT
cajgh-231	359	14	strand	strand	NOUN
cajgh-231	359	15	break	break	NOUN
cajgh-231	359	16	repair	repair	NOUN
cajgh-231	359	17	pathways	pathway	NOUN
cajgh-231	359	18	that	that	PRON
cajgh-231	359	19	promote	promote	VERB
cajgh-231	359	20	genome	genome	NOUN
cajgh-231	359	21	rearrangements	rearrangement	NOUN
cajgh-231	359	22	.	.	PUNCT
cajgh-231	360	1	genes	gene	NOUN
cajgh-231	360	2	dev	dev	PROPN
cajgh-231	360	3	.	.	PUNCT
cajgh-231	361	1	vol	vol	NOUN
cajgh-231	361	2	212007:1064	212007:1064	NUM
cajgh-231	361	3	-	-	SYM
cajgh-231	361	4	1074	1074	NUM
cajgh-231	361	5	.	.	PUNCT
cajgh-231	362	1	61	61	NUM
cajgh-231	362	2	.	.	PUNCT
cajgh-231	363	1	shao	shao	PROPN
cajgh-231	363	2	l	l	PROPN
cajgh-231	363	3	,	,	PUNCT
cajgh-231	363	4	luo	luo	PROPN
cajgh-231	363	5	y	y	PROPN
cajgh-231	363	6	,	,	PUNCT
cajgh-231	363	7	zhou	zhou	PROPN
cajgh-231	363	8	d.	d.	PROPN
cajgh-231	363	9	hematopoietic	hematopoietic	PROPN
cajgh-231	363	10	stemcell	stemcell	PROPN
cajgh-231	363	11	injury	injury	PROPN
cajgh-231	363	12	induced	induce	VERB
cajgh-231	363	13	by	by	ADP
cajgh-231	363	14	ionizing	ionize	VERB
cajgh-231	363	15	radiation	radiation	NOUN
cajgh-231	363	16	.	.	PUNCT
cajgh-231	364	1	antioxid	antioxid	VERB
cajgh-231	364	2	redox	redox	NOUN
cajgh-231	364	3	signal	signal	NOUN
cajgh-231	364	4	.	.	PUNCT
cajgh-231	365	1	vol	vol	NOUN
cajgh-231	365	2	202014:1447	202014:1447	NUM
cajgh-231	365	3	-	-	SYM
cajgh-231	365	4	1462	1462	NUM
cajgh-231	365	5	.	.	PUNCT
cajgh-231	366	1	62	62	NUM
cajgh-231	366	2	.	.	PUNCT
cajgh-231	366	3	owusu	owusu	PROPN
cajgh-231	366	4	-	-	PUNCT
cajgh-231	366	5	ansah	ansah	PROPN
cajgh-231	366	6	e	e	PROPN
cajgh-231	366	7	,	,	PUNCT
cajgh-231	366	8	banerjee	banerjee	PROPN
cajgh-231	366	9	u.	u.	PROPN
cajgh-231	366	10	reactive	reactive	ADJ
cajgh-231	366	11	oxygen	oxygen	NOUN
cajgh-231	366	12	species	specie	NOUN
cajgh-231	366	13	prime	prime	ADJ
cajgh-231	366	14	drosophila	drosophila	NOUN
cajgh-231	366	15	hematopoietic	hematopoietic	ADJ
cajgh-231	366	16	progenitors	progenitor	NOUN
cajgh-231	366	17	for	for	ADP
cajgh-231	366	18	differentiation	differentiation	NOUN
cajgh-231	366	19	.	.	PUNCT
cajgh-231	367	1	nature	nature	NOUN
cajgh-231	367	2	.	.	PUNCT
cajgh-231	368	1	vol	vol	NOUN
cajgh-231	368	2	4612009:537	4612009:537	NUM
cajgh-231	368	3	-	-	SYM
cajgh-231	368	4	541	541	NUM
cajgh-231	368	5	.	.	PUNCT
cajgh-231	369	1	63	63	NUM
cajgh-231	369	2	.	.	PUNCT
cajgh-231	370	1	yahata	yahata	PROPN
cajgh-231	370	2	t	t	PROPN
cajgh-231	370	3	,	,	PUNCT
cajgh-231	370	4	takanashi	takanashi	PROPN
cajgh-231	370	5	t	t	PROPN
cajgh-231	370	6	,	,	PUNCT
cajgh-231	370	7	muguruma	muguruma	PROPN
cajgh-231	370	8	y	y	PROPN
cajgh-231	370	9	,	,	PUNCT
cajgh-231	370	10	et	et	PROPN
cajgh-231	370	11	al	al	PROPN
cajgh-231	370	12	.	.	PROPN
cajgh-231	370	13	accumulation	accumulation	NOUN
cajgh-231	370	14	of	of	ADP
cajgh-231	370	15	oxidative	oxidative	ADJ
cajgh-231	370	16	dna	dna	PROPN
cajgh-231	370	17	damage	damage	NOUN
cajgh-231	370	18	restricts	restrict	VERB
cajgh-231	370	19	the	the	DET
cajgh-231	370	20	self	self	NOUN
cajgh-231	370	21	-	-	PUNCT
cajgh-231	370	22	renewal	renewal	NOUN
cajgh-231	370	23	capacity	capacity	NOUN
cajgh-231	370	24	of	of	ADP
cajgh-231	370	25	human	human	ADJ
cajgh-231	370	26	hematopoietic	hematopoietic	ADJ
cajgh-231	370	27	stem	stem	NOUN
cajgh-231	370	28	cells	cell	NOUN
cajgh-231	370	29	.	.	PUNCT
cajgh-231	371	1	blood	blood	NOUN
cajgh-231	371	2	.	.	PUNCT
cajgh-231	372	1	vol	vol	NOUN
cajgh-231	372	2	118	118	NUM
cajgh-231	372	3	(	(	PUNCT
cajgh-231	372	4	11)2011:2941	11)2011:2941	NUM
cajgh-231	372	5	-	-	SYM
cajgh-231	372	6	2950	2950	NUM
cajgh-231	372	7	.	.	PUNCT
cajgh-231	373	1	64	64	NUM
cajgh-231	373	2	.	.	PUNCT
cajgh-231	374	1	chen	chen	PROPN
cajgh-231	374	2	j	j	PROPN
cajgh-231	374	3	,	,	PUNCT
cajgh-231	374	4	astle	astle	PROPN
cajgh-231	374	5	cm	cm	PROPN
cajgh-231	374	6	,	,	PUNCT
cajgh-231	374	7	harrison	harrison	PROPN
cajgh-231	374	8	de	de	PROPN
cajgh-231	374	9	.	.	PROPN
cajgh-231	374	10	hematopoietic	hematopoietic	ADJ
cajgh-231	374	11	senescence	senescence	NOUN
cajgh-231	374	12	is	be	AUX
cajgh-231	374	13	postponed	postpone	VERB
cajgh-231	374	14	and	and	CCONJ
cajgh-231	374	15	hematopoietic	hematopoietic	ADJ
cajgh-231	374	16	stem	stem	NOUN
cajgh-231	374	17	cell	cell	NOUN
cajgh-231	374	18	function	function	NOUN
cajgh-231	374	19	is	be	AUX
cajgh-231	374	20	enhanced	enhance	VERB
cajgh-231	374	21	by	by	ADP
cajgh-231	374	22	dietary	dietary	ADJ
cajgh-231	374	23	restriction	restriction	NOUN
cajgh-231	374	24	.	.	PUNCT
cajgh-231	375	1	exp	exp	NOUN
cajgh-231	375	2	hematol	hematol	NOUN
cajgh-231	375	3	.	.	PUNCT
cajgh-231	376	1	vol	vol	NOUN
cajgh-231	376	2	312003:1097	312003:1097	NUM
cajgh-231	376	3	-	-	SYM
cajgh-231	376	4	1103	1103	NUM
cajgh-231	376	5	.	.	PUNCT
cajgh-231	377	1	65	65	NUM
cajgh-231	377	2	.	.	PUNCT
cajgh-231	378	1	ito	ito	PROPN
cajgh-231	378	2	k	k	PROPN
cajgh-231	378	3	,	,	PUNCT
cajgh-231	378	4	hirao	hirao	PROPN
cajgh-231	378	5	a	a	X
cajgh-231	378	6	,	,	PUNCT
cajgh-231	378	7	arai	arai	PROPN
cajgh-231	378	8	f	f	PROPN
cajgh-231	378	9	,	,	PUNCT
cajgh-231	378	10	et	et	PROPN
cajgh-231	378	11	al	al	PROPN
cajgh-231	378	12	.	.	PROPN
cajgh-231	378	13	reactive	reactive	ADJ
cajgh-231	378	14	oxygen	oxygen	NOUN
cajgh-231	378	15	species	specie	NOUN
cajgh-231	378	16	act	act	VERB
cajgh-231	378	17	through	through	ADP
cajgh-231	378	18	p38	p38	NOUN
cajgh-231	378	19	mapk	mapk	NOUN
cajgh-231	378	20	to	to	PART
cajgh-231	378	21	limit	limit	VERB
cajgh-231	378	22	the	the	DET
cajgh-231	378	23	lifespan	lifespan	NOUN
cajgh-231	378	24	of	of	ADP
cajgh-231	378	25	hematopoietic	hematopoietic	ADJ
cajgh-231	378	26	stem	stem	NOUN
cajgh-231	378	27	cells	cell	NOUN
cajgh-231	378	28	.	.	PUNCT
cajgh-231	379	1	nat	nat	PROPN
cajgh-231	379	2	med	med	PROPN
cajgh-231	379	3	.	.	PUNCT
cajgh-231	380	1	vol	vol	NOUN
cajgh-231	380	2	122006:446–451	122006:446–451	NUM
cajgh-231	380	3	.	.	PUNCT
cajgh-231	381	1	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	381	2	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	381	3	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	PUNCT
cajgh-231	381	4	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	381	5	valente	valente	NOUN
cajgh-231	381	6	this	this	DET
cajgh-231	381	7	work	work	NOUN
cajgh-231	381	8	is	be	AUX
cajgh-231	381	9	licensed	license	VERB
cajgh-231	381	10	under	under	ADP
cajgh-231	381	11	a	a	DET
cajgh-231	381	12	creative	creative	ADJ
cajgh-231	381	13	commons	common	NOUN
cajgh-231	381	14	attribution	attribution	NOUN
cajgh-231	381	15	4.0	4.0	NUM
cajgh-231	381	16	united	unite	VERB
cajgh-231	381	17	states	states	PROPN
cajgh-231	381	18	license	license	NOUN
cajgh-231	381	19	.	.	PUNCT
cajgh-231	382	1	this	this	DET
cajgh-231	382	2	journal	journal	NOUN
cajgh-231	382	3	is	be	AUX
cajgh-231	382	4	published	publish	VERB
cajgh-231	382	5	by	by	ADP
cajgh-231	382	6	theuniversity	theuniversity	NOUN
cajgh-231	382	7	library	library	NOUN
cajgh-231	382	8	system	system	NOUN
cajgh-231	382	9	of	of	ADP
cajgh-231	382	10	the	the	DET
cajgh-231	382	11	university	university	PROPN
cajgh-231	382	12	of	of	ADP
cajgh-231	382	13	pittsburgh	pittsburgh	PROPN
cajgh-231	382	14	as	as	ADP
cajgh-231	382	15	part	part	NOUN
cajgh-231	382	16	of	of	ADP
cajgh-231	382	17	its	its	PRON
cajgh-231	382	18	d	d	NOUN
cajgh-231	382	19	-	-	PUNCT
cajgh-231	382	20	scribe	scribe	VERB
cajgh-231	382	21	digital	digital	ADJ
cajgh-231	382	22	publishing	publishing	NOUN
cajgh-231	382	23	program	program	NOUN
cajgh-231	382	24	and	and	CCONJ
cajgh-231	382	25	is	be	AUX
cajgh-231	382	26	cosponsored	cosponsor	VERB
cajgh-231	382	27	by	by	ADP
cajgh-231	382	28	the	the	DET
cajgh-231	382	29	university	university	PROPN
cajgh-231	382	30	of	of	ADP
cajgh-231	382	31	pittsburgh	pittsburgh	PROPN
cajgh-231	382	32	press	press	NOUN
cajgh-231	382	33	.	.	PUNCT
cajgh-231	383	1	central	central	ADJ
cajgh-231	383	2	asian	asian	ADJ
cajgh-231	383	3	journal	journal	NOUN
cajgh-231	383	4	of	of	ADP
cajgh-231	383	5	global	global	ADJ
cajgh-231	383	6	health	health	NOUN
cajgh-231	383	7	volume	volume	NOUN
cajgh-231	383	8	4	4	NUM
cajgh-231	383	9	,	,	PUNCT
cajgh-231	383	10	no	no	INTJ
cajgh-231	383	11	.	.	NOUN
cajgh-231	383	12	1	1	NUM
cajgh-231	383	13	(	(	PUNCT
cajgh-231	383	14	2015	2015	NUM
cajgh-231	383	15	)	)	PUNCT
cajgh-231	383	16	|	|	ADV
cajgh-231	383	17	issn	issn	VERB
cajgh-231	383	18	2166	2166	NUM
cajgh-231	383	19	-	-	SYM
cajgh-231	383	20	7403	7403	NUM
cajgh-231	383	21	(	(	PUNCT
cajgh-231	383	22	online	online	ADJ
cajgh-231	383	23	)	)	PUNCT
cajgh-231	383	24	|	|	ADV
cajgh-231	383	25	doi	doi	X
cajgh-231	383	26	10.5195	10.5195	NUM
cajgh-231	383	27	/	/	SYM
cajgh-231	383	28	cajgh.2016.231|http://cajgh.pitt.edu	cajgh.2016.231|http://cajgh.pitt.edu	NOUN
cajgh-231	383	29	66	66	NUM
cajgh-231	383	30	.	.	PUNCT
cajgh-231	384	1	brown	brown	PROPN
cajgh-231	384	2	k	k	PROPN
cajgh-231	384	3	,	,	PUNCT
cajgh-231	384	4	xie	xie	PROPN
cajgh-231	384	5	s	s	PROPN
cajgh-231	384	6	,	,	PUNCT
cajgh-231	384	7	qiu	qiu	PROPN
cajgh-231	384	8	x	x	NOUN
cajgh-231	384	9	,	,	PUNCT
cajgh-231	384	10	et	et	PROPN
cajgh-231	384	11	al	al	PROPN
cajgh-231	384	12	.	.	PUNCT
cajgh-231	384	13	sirt3	sirt3	PROPN
cajgh-231	384	14	reverses	reverse	VERB
cajgh-231	384	15	aging	age	VERB
cajgh-231	384	16	-	-	PUNCT
cajgh-231	384	17	associated	associate	VERB
cajgh-231	384	18	degeneration	degeneration	NOUN
cajgh-231	384	19	.	.	PUNCT
cajgh-231	385	1	cell	cell	NOUN
cajgh-231	385	2	rep	rep	PROPN
cajgh-231	385	3	.	.	PROPN
cajgh-231	385	4	vol	vol	PROPN
cajgh-231	385	5	32013:319	32013:319	NUM
cajgh-231	385	6	-	-	PUNCT
cajgh-231	385	7	327	327	NUM
cajgh-231	385	8	.	.	NOUN
cajgh-231	385	9	67	67	NUM
cajgh-231	385	10	.	.	PUNCT
cajgh-231	386	1	tothova	tothova	PROPN
cajgh-231	387	1	z	z	X
cajgh-231	387	2	,	,	PUNCT
cajgh-231	387	3	kollipara	kollipara	PROPN
cajgh-231	387	4	r	r	NOUN
cajgh-231	387	5	,	,	PUNCT
cajgh-231	387	6	huntly	huntly	ADJ
cajgh-231	387	7	bj	bj	NOUN
cajgh-231	387	8	,	,	PUNCT
cajgh-231	387	9	et	et	PROPN
cajgh-231	387	10	al	al	PROPN
cajgh-231	387	11	.	.	PROPN
cajgh-231	388	1	foxos	foxos	PROPN
cajgh-231	388	2	are	be	AUX
cajgh-231	388	3	critical	critical	ADJ
cajgh-231	388	4	mediators	mediator	NOUN
cajgh-231	388	5	of	of	ADP
cajgh-231	388	6	hematopoietic	hematopoietic	ADJ
cajgh-231	388	7	stem	stem	NOUN
cajgh-231	388	8	cell	cell	NOUN
cajgh-231	388	9	resistance	resistance	NOUN
cajgh-231	388	10	to	to	ADP
cajgh-231	388	11	physiologic	physiologic	ADJ
cajgh-231	388	12	oxidative	oxidative	ADJ
cajgh-231	388	13	stress	stress	NOUN
cajgh-231	388	14	.	.	PUNCT
cajgh-231	389	1	cell	cell	NOUN
cajgh-231	389	2	.	.	PUNCT
cajgh-231	390	1	vol	vol	NOUN
cajgh-231	390	2	1282007:325–339	1282007:325–339	NUM
cajgh-231	390	3	.	.	PUNCT
cajgh-231	391	1	68	68	NUM
cajgh-231	391	2	.	.	PUNCT
cajgh-231	392	1	abbas	abbas	PROPN
cajgh-231	392	2	ha	ha	SYM
cajgh-231	392	3	,	,	PUNCT
cajgh-231	392	4	maccio	maccio	PROPN
cajgh-231	392	5	dr	dr	PROPN
cajgh-231	392	6	,	,	PUNCT
cajgh-231	392	7	coskun	coskun	PROPN
cajgh-231	392	8	s	s	PROPN
cajgh-231	392	9	,	,	PUNCT
cajgh-231	392	10	jackson	jackson	PROPN
cajgh-231	392	11	jg	jg	PROPN
cajgh-231	392	12	,	,	PUNCT
cajgh-231	392	13	hazen	hazen	PROPN
cajgh-231	392	14	al	al	PROPN
cajgh-231	392	15	,	,	PUNCT
cajgh-231	392	16	sills	sill	VERB
cajgh-231	392	17	tm	tm	PROPN
cajgh-231	392	18	.	.	PUNCT
cajgh-231	392	19	mdm2	mdm2	PROPN
cajgh-231	392	20	is	be	AUX
cajgh-231	392	21	required	require	VERB
cajgh-231	392	22	for	for	ADP
cajgh-231	392	23	survival	survival	NOUN
cajgh-231	392	24	of	of	ADP
cajgh-231	392	25	hematopoietic	hematopoietic	ADJ
cajgh-231	392	26	stem	stem	NOUN
cajgh-231	392	27	cells	cell	NOUN
cajgh-231	392	28	/	/	SYM
cajgh-231	392	29	progenitors	progenitor	NOUN
cajgh-231	392	30	via	via	ADP
cajgh-231	392	31	dampening	dampen	VERB
cajgh-231	392	32	of	of	ADP
cajgh-231	392	33	rosinduced	rosinduce	VERB
cajgh-231	392	34	p53	p53	NOUN
cajgh-231	392	35	activity	activity	NOUN
cajgh-231	392	36	.	.	PUNCT
cajgh-231	393	1	cell	cell	NOUN
cajgh-231	393	2	stem	stem	NOUN
cajgh-231	393	3	cell	cell	NOUN
cajgh-231	393	4	.	.	PUNCT
cajgh-231	394	1	vol	vol	NOUN
cajgh-231	394	2	72010:606	72010:606	NUM
cajgh-231	394	3	-	-	PUNCT
cajgh-231	394	4	617	617	NUM
cajgh-231	394	5	.	.	PUNCT
cajgh-231	394	6	69	69	NUM
cajgh-231	394	7	.	.	PUNCT
cajgh-231	395	1	yalcin	yalcin	PROPN
cajgh-231	395	2	s	s	NOUN
cajgh-231	395	3	,	,	PUNCT
cajgh-231	395	4	marinkovic	marinkovic	PROPN
cajgh-231	395	5	d	d	NOUN
cajgh-231	395	6	,	,	PUNCT
cajgh-231	395	7	mungamuri	mungamuri	NOUN
cajgh-231	395	8	sk	sk	PROPN
cajgh-231	395	9	,	,	PUNCT
cajgh-231	395	10	et	et	PROPN
cajgh-231	395	11	al	al	PROPN
cajgh-231	395	12	.	.	PROPN
cajgh-231	395	13	ros‐mediated	ros‐mediate	VERB
cajgh-231	395	14	amplification	amplification	NOUN
cajgh-231	395	15	of	of	ADP
cajgh-231	395	16	akt	akt	PROPN
cajgh-231	395	17	/	/	SYM
cajgh-231	395	18	mtor	mtor	PROPN
cajgh-231	395	19	signalling	signal	VERB
cajgh-231	395	20	pathway	pathway	NOUN
cajgh-231	395	21	leads	lead	VERB
cajgh-231	395	22	to	to	ADP
cajgh-231	395	23	myeloproliferative	myeloproliferative	ADJ
cajgh-231	395	24	syndrome	syndrome	NOUN
cajgh-231	395	25	in	in	ADP
cajgh-231	395	26	foxo3−/−	foxo3−/−	ADJ
cajgh-231	395	27	mice	mouse	NOUN
cajgh-231	395	28	.	.	PUNCT
cajgh-231	396	1	embo	embo	PROPN
cajgh-231	396	2	j.	j.	PROPN
cajgh-231	396	3	vol	vol	PROPN
cajgh-231	396	4	29	29	NUM
cajgh-231	396	5	(	(	PUNCT
cajgh-231	396	6	24)2010:4118–4131	24)2010:4118–4131	NUM
cajgh-231	396	7	.	.	NOUN
cajgh-231	396	8	70	70	NUM
cajgh-231	396	9	.	.	PUNCT
cajgh-231	397	1	ito	ito	PROPN
cajgh-231	397	2	k	k	PROPN
cajgh-231	397	3	,	,	PUNCT
cajgh-231	397	4	hirao	hirao	PROPN
cajgh-231	397	5	a	a	X
cajgh-231	397	6	,	,	PUNCT
cajgh-231	397	7	arai	arai	PROPN
cajgh-231	397	8	f	f	PROPN
cajgh-231	397	9	,	,	PUNCT
cajgh-231	397	10	et	et	PROPN
cajgh-231	397	11	al	al	PROPN
cajgh-231	397	12	.	.	PUNCT
cajgh-231	397	13	regulation	regulation	NOUN
cajgh-231	397	14	of	of	ADP
cajgh-231	397	15	oxidative	oxidative	ADJ
cajgh-231	397	16	stress	stress	NOUN
cajgh-231	397	17	by	by	ADP
cajgh-231	397	18	atm	atm	NOUN
cajgh-231	397	19	is	be	AUX
cajgh-231	397	20	required	require	VERB
cajgh-231	397	21	for	for	ADP
cajgh-231	397	22	selfrenewal	selfrenewal	NOUN
cajgh-231	397	23	of	of	ADP
cajgh-231	397	24	haematopoietic	haematopoietic	ADJ
cajgh-231	397	25	stem	stem	NOUN
cajgh-231	397	26	-	-	PUNCT
cajgh-231	397	27	cells	cell	NOUN
cajgh-231	397	28	.	.	PUNCT
cajgh-231	398	1	nature	nature	NOUN
cajgh-231	398	2	.	.	PUNCT
cajgh-231	399	1	vol	vol	NOUN
cajgh-231	399	2	4312004:997	4312004:997	NOUN
cajgh-231	399	3	-	-	PUNCT
cajgh-231	399	4	1002	1002	NUM
cajgh-231	399	5	.	.	PUNCT
cajgh-231	400	1	71	71	NUM
cajgh-231	400	2	.	.	PUNCT
cajgh-231	401	1	xiao	xiao	PROPN
cajgh-231	401	2	w	w	PROPN
cajgh-231	401	3	,	,	PUNCT
cajgh-231	401	4	shameli	shameli	PROPN
cajgh-231	401	5	a	a	PROPN
cajgh-231	401	6	,	,	PUNCT
cajgh-231	401	7	harding	harding	PROPN
cajgh-231	401	8	cv	cv	PROPN
cajgh-231	401	9	,	,	PUNCT
cajgh-231	401	10	meyerson	meyerson	PROPN
cajgh-231	401	11	hj	hj	PROPN
cajgh-231	401	12	,	,	PUNCT
cajgh-231	401	13	maitta	maitta	VERB
cajgh-231	401	14	rw	rw	NOUN
cajgh-231	401	15	.	.	PUNCT
cajgh-231	402	1	late	late	ADJ
cajgh-231	402	2	stages	stage	NOUN
cajgh-231	402	3	of	of	ADP
cajgh-231	402	4	hematopoiesis	hematopoiesis	NOUN
cajgh-231	402	5	and	and	CCONJ
cajgh-231	402	6	b	b	NOUN
cajgh-231	402	7	cell	cell	NOUN
cajgh-231	402	8	lymphopoiesis	lymphopoiesis	NOUN
cajgh-231	402	9	are	be	AUX
cajgh-231	402	10	regulated	regulate	VERB
cajgh-231	402	11	by	by	ADP
cajgh-231	402	12	αsynuclein	αsynuclein	NOUN
cajgh-231	402	13	,	,	PUNCT
cajgh-231	402	14	a	a	DET
cajgh-231	402	15	key	key	ADJ
cajgh-231	402	16	player	player	NOUN
cajgh-231	402	17	in	in	ADP
cajgh-231	402	18	parkinson	parkinson	NOUN
cajgh-231	402	19	's	's	PART
cajgh-231	402	20	disease	disease	NOUN
cajgh-231	402	21	.	.	PUNCT
cajgh-231	403	1	immunobiology	immunobiology	NOUN
cajgh-231	403	2	.	.	PUNCT
cajgh-231	404	1	vol	vol	NOUN
cajgh-231	404	2	2192014:836	2192014:836	NUM
cajgh-231	404	3	-	-	PUNCT
cajgh-231	404	4	844	844	NUM
cajgh-231	404	5	.	.	NOUN
cajgh-231	404	6	72	72	NUM
cajgh-231	404	7	.	.	PUNCT
cajgh-231	405	1	valente	valente	PROPN
cajgh-231	405	2	axcn	axcn	PROPN
cajgh-231	405	3	,	,	PUNCT
cajgh-231	405	4	shin	shin	PROPN
cajgh-231	405	5	jh	jh	PROPN
cajgh-231	405	6	,	,	PUNCT
cajgh-231	405	7	sarkar	sarkar	PROPN
cajgh-231	405	8	a	a	X
cajgh-231	405	9	,	,	PUNCT
cajgh-231	405	10	gao	gao	PROPN
cajgh-231	405	11	y.	y.	PROPN
cajgh-231	405	12	rare	rare	PROPN
cajgh-231	405	13	coding	code	VERB
cajgh-231	405	14	snp	snp	NOUN
cajgh-231	405	15	in	in	ADP
cajgh-231	405	16	dzip1	dzip1	PROPN
cajgh-231	405	17	gene	gene	NOUN
cajgh-231	405	18	associated	associate	VERB
cajgh-231	405	19	with	with	ADP
cajgh-231	405	20	late	late	ADJ
cajgh-231	405	21	-	-	PUNCT
cajgh-231	405	22	onset	onset	NOUN
cajgh-231	405	23	sporadic	sporadic	ADJ
cajgh-231	405	24	parkinson	parkinson	NOUN
cajgh-231	405	25	's	's	PART
cajgh-231	405	26	disease	disease	NOUN
cajgh-231	405	27	.	.	PUNCT
cajgh-231	406	1	sci	sci	PROPN
cajgh-231	406	2	rep	rep	PROPN
cajgh-231	406	3	.	.	PROPN
cajgh-231	406	4	vol	vol	NOUN
cajgh-231	406	5	2	2	NUM
cajgh-231	406	6	art	art	NOUN
cajgh-231	406	7	.	.	PUNCT
cajgh-231	407	1	no	no	INTJ
cajgh-231	407	2	.	.	NOUN
cajgh-231	408	1	2562012	2562012	NUM
cajgh-231	408	2	.	.	PUNCT
cajgh-231	409	1	73	73	NUM
cajgh-231	409	2	.	.	PUNCT
cajgh-231	410	1	sekimizu	sekimizu	PROPN
cajgh-231	410	2	k	k	NOUN
cajgh-231	410	3	,	,	PUNCT
cajgh-231	410	4	nishioka	nishioka	ADJ
cajgh-231	410	5	n	n	CCONJ
cajgh-231	410	6	,	,	PUNCT
cajgh-231	410	7	sasaki	sasaki	PROPN
cajgh-231	410	8	h	h	PROPN
cajgh-231	410	9	,	,	PUNCT
cajgh-231	410	10	takeda	takeda	PROPN
cajgh-231	410	11	h	h	PROPN
cajgh-231	410	12	,	,	PUNCT
cajgh-231	410	13	karlstrom	karlstrom	PROPN
cajgh-231	410	14	ro	ro	PROPN
cajgh-231	410	15	,	,	PUNCT
cajgh-231	410	16	kawakami	kawakami	PROPN
cajgh-231	410	17	a.	a.	PROPN
cajgh-231	410	18	the	the	DET
cajgh-231	410	19	zebrafish	zebrafish	ADJ
cajgh-231	410	20	iguana	iguana	NOUN
cajgh-231	410	21	locus	locus	NOUN
cajgh-231	410	22	encodes	encode	NOUN
cajgh-231	410	23	dzip1	dzip1	PROPN
cajgh-231	410	24	,	,	PUNCT
cajgh-231	410	25	a	a	DET
cajgh-231	410	26	novel	novel	ADJ
cajgh-231	410	27	zincfinger	zincfinger	NOUN
cajgh-231	410	28	protein	protein	NOUN
cajgh-231	410	29	required	require	VERB
cajgh-231	410	30	for	for	ADP
cajgh-231	410	31	proper	proper	ADJ
cajgh-231	410	32	regulation	regulation	NOUN
cajgh-231	410	33	of	of	ADP
cajgh-231	410	34	hedgehog	hedgehog	NOUN
cajgh-231	410	35	signaling	signaling	NOUN
cajgh-231	410	36	.	.	PUNCT
cajgh-231	411	1	vol	vol	NOUN
cajgh-231	411	2	131	131	NUM
cajgh-231	411	3	(	(	PUNCT
cajgh-231	411	4	11)2004:25212532	11)2004:25212532	NUM
cajgh-231	411	5	.	.	PROPN
cajgh-231	411	6	74	74	NUM
cajgh-231	411	7	.	.	PUNCT
cajgh-231	412	1	palma	palma	PROPN
cajgh-231	412	2	v	v	PROPN
cajgh-231	412	3	,	,	PUNCT
cajgh-231	412	4	lim	lim	PROPN
cajgh-231	412	5	da	da	PROPN
cajgh-231	412	6	,	,	PUNCT
cajgh-231	412	7	dahmane	dahmane	NOUN
cajgh-231	412	8	n	n	CCONJ
cajgh-231	412	9	,	,	PUNCT
cajgh-231	412	10	sánchez	sánchez	NOUN
cajgh-231	412	11	p	p	NOUN
cajgh-231	412	12	,	,	PUNCT
cajgh-231	412	13	brionne	brionne	PROPN
cajgh-231	412	14	tc	tc	PROPN
cajgh-231	412	15	.	.	PUNCT
cajgh-231	412	16	sonic	sonic	ADJ
cajgh-231	412	17	hedgehog	hedgehog	PROPN
cajgh-231	412	18	controls	control	NOUN
cajgh-231	412	19	stem	stem	NOUN
cajgh-231	412	20	cell	cell	NOUN
cajgh-231	412	21	behavior	behavior	NOUN
cajgh-231	412	22	in	in	ADP
cajgh-231	412	23	the	the	DET
cajgh-231	412	24	postnatal	postnatal	ADJ
cajgh-231	412	25	and	and	CCONJ
cajgh-231	412	26	adult	adult	NOUN
cajgh-231	412	27	brain	brain	NOUN
cajgh-231	412	28	.	.	PUNCT
cajgh-231	413	1	development	development	NOUN
cajgh-231	413	2	.	.	PUNCT
cajgh-231	414	1	vol	vol	NOUN
cajgh-231	414	2	132	132	NUM
cajgh-231	414	3	(	(	PUNCT
cajgh-231	414	4	2)2004:335	2)2004:335	NUM
cajgh-231	414	5	-	-	SYM
cajgh-231	414	6	344	344	NUM
cajgh-231	414	7	.	.	PUNCT
cajgh-231	414	8	75	75	NUM
cajgh-231	414	9	.	.	PUNCT
cajgh-231	415	1	bhardwaj	bhardwaj	PROPN
cajgh-231	415	2	g	g	PROPN
cajgh-231	415	3	,	,	PUNCT
cajgh-231	415	4	murdoch	murdoch	PROPN
cajgh-231	415	5	b	b	PROPN
cajgh-231	415	6	,	,	PUNCT
cajgh-231	415	7	wu	wu	PROPN
cajgh-231	415	8	d	d	PROPN
cajgh-231	415	9	,	,	PUNCT
cajgh-231	415	10	baker	baker	PROPN
cajgh-231	415	11	dp	dp	PROPN
cajgh-231	415	12	,	,	PUNCT
cajgh-231	415	13	williams	williams	PROPN
cajgh-231	415	14	kp	kp	PROPN
cajgh-231	415	15	.	.	PROPN
cajgh-231	415	16	sonic	sonic	ADJ
cajgh-231	415	17	hedgehog	hedgehog	PROPN
cajgh-231	415	18	induces	induce	VERB
cajgh-231	415	19	the	the	DET
cajgh-231	415	20	proliferation	proliferation	NOUN
cajgh-231	415	21	of	of	ADP
cajgh-231	415	22	primitive	primitive	ADJ
cajgh-231	415	23	human	human	ADJ
cajgh-231	415	24	hematopoietic	hematopoietic	ADJ
cajgh-231	415	25	cells	cell	NOUN
cajgh-231	415	26	via	via	ADP
cajgh-231	415	27	bmp	bmp	PROPN
cajgh-231	415	28	regulation	regulation	NOUN
cajgh-231	415	29	.	.	PUNCT
cajgh-231	416	1	nature	nature	NOUN
cajgh-231	416	2	immunol	immunol	NOUN
cajgh-231	416	3	.	.	PUNCT
cajgh-231	417	1	vol	vol	NOUN
cajgh-231	417	2	22001:172	22001:172	NUM
cajgh-231	417	3	-	-	PUNCT
cajgh-231	417	4	180	180	NUM
cajgh-231	417	5	.	.	PUNCT
cajgh-231	418	1	76	76	NUM
cajgh-231	418	2	.	.	PUNCT
cajgh-231	419	1	sidransky	sidransky	PROPN
cajgh-231	419	2	e	e	PROPN
cajgh-231	419	3	,	,	PUNCT
cajgh-231	419	4	nalls	nalls	PROPN
cajgh-231	419	5	ma	ma	PROPN
cajgh-231	419	6	,	,	PUNCT
cajgh-231	419	7	aasly	aasly	ADV
cajgh-231	419	8	jo	jo	PROPN
cajgh-231	419	9	,	,	PUNCT
cajgh-231	419	10	et	et	PROPN
cajgh-231	419	11	al	al	PROPN
cajgh-231	419	12	.	.	PUNCT
cajgh-231	420	1	multicenter	multicenter	ADJ
cajgh-231	420	2	analysis	analysis	NOUN
cajgh-231	420	3	of	of	ADP
cajgh-231	420	4	glucocerebrosidase	glucocerebrosidase	NOUN
cajgh-231	420	5	mutations	mutation	NOUN
cajgh-231	420	6	in	in	ADP
cajgh-231	420	7	parkinson	parkinson	NOUN
cajgh-231	420	8	's	's	PART
cajgh-231	420	9	disease	disease	NOUN
cajgh-231	420	10	.	.	PUNCT
cajgh-231	421	1	n	n	PROPN
cajgh-231	421	2	engl	engl	PROPN
cajgh-231	421	3	j	j	PROPN
cajgh-231	421	4	med	med	PROPN
cajgh-231	421	5	.	.	PUNCT
cajgh-231	422	1	vol	vol	NOUN
cajgh-231	422	2	3612009:1651	3612009:1651	NUM
cajgh-231	422	3	-	-	SYM
cajgh-231	422	4	1661	1661	NUM
cajgh-231	422	5	.	.	PUNCT
cajgh-231	423	1	77	77	NUM
cajgh-231	423	2	.	.	PUNCT
cajgh-231	424	1	mingyi	mingyi	PROPN
cajgh-231	424	2	c	c	PROPN
cajgh-231	424	3	,	,	PUNCT
cajgh-231	424	4	jun	jun	PROPN
cajgh-231	424	5	w.	w.	PROPN
cajgh-231	424	6	gaucher	gaucher	PROPN
cajgh-231	424	7	disease	disease	PROPN
cajgh-231	424	8	:	:	PUNCT
cajgh-231	424	9	review	review	NOUN
cajgh-231	424	10	of	of	ADP
cajgh-231	424	11	the	the	DET
cajgh-231	424	12	literature	literature	NOUN
cajgh-231	424	13	.	.	PUNCT
cajgh-231	425	1	arch	arch	ADJ
cajgh-231	425	2	pathol	pathol	PROPN
cajgh-231	425	3	lab	lab	NOUN
cajgh-231	425	4	med	me	VERB
cajgh-231	425	5	.	.	PUNCT
cajgh-231	426	1	vol	vol	NOUN
cajgh-231	426	2	132.52008:851	132.52008:851	NUM
cajgh-231	426	3	-	-	SYM
cajgh-231	426	4	853	853	NUM
cajgh-231	426	5	.	.	PUNCT
cajgh-231	427	1	78	78	NUM
cajgh-231	427	2	.	.	PUNCT
cajgh-231	428	1	dawson	dawson	PROPN
cajgh-231	428	2	tm	tm	PROPN
cajgh-231	428	3	.	.	PUNCT
cajgh-231	429	1	new	new	ADJ
cajgh-231	429	2	animal	animal	NOUN
cajgh-231	429	3	models	model	NOUN
cajgh-231	429	4	for	for	ADP
cajgh-231	429	5	parkinson	parkinson	NOUN
cajgh-231	429	6	's	's	PART
cajgh-231	429	7	disease	disease	NOUN
cajgh-231	429	8	.	.	PUNCT
cajgh-231	430	1	cell	cell	NOUN
cajgh-231	430	2	.	.	PUNCT
cajgh-231	431	1	vol	vol	NOUN
cajgh-231	431	2	101	101	NUM
cajgh-231	431	3	(	(	PUNCT
cajgh-231	431	4	2)2000:115–118	2)2000:115–118	NUM
cajgh-231	431	5	.	.	PUNCT
cajgh-231	431	6	79	79	NUM
cajgh-231	431	7	.	.	PUNCT
cajgh-231	432	1	natale	natale	PROPN
cajgh-231	432	2	g	g	PROPN
cajgh-231	432	3	,	,	PUNCT
cajgh-231	432	4	pasquali	pasquali	PROPN
cajgh-231	432	5	l	l	PROPN
cajgh-231	432	6	,	,	PUNCT
cajgh-231	432	7	ruggieri	ruggieri	PROPN
cajgh-231	432	8	sap	sap	PROPN
cajgh-231	432	9	,	,	PUNCT
cajgh-231	432	10	fornai	fornai	PROPN
cajgh-231	432	11	f.	f.	PROPN
cajgh-231	432	12	parkinson	parkinson	PROPN
cajgh-231	432	13	's	's	PART
cajgh-231	432	14	disease	disease	NOUN
cajgh-231	432	15	and	and	CCONJ
cajgh-231	432	16	the	the	DET
cajgh-231	432	17	gut	gut	NOUN
cajgh-231	432	18	:	:	PUNCT
cajgh-231	432	19	a	a	DET
cajgh-231	432	20	well	well	ADV
cajgh-231	432	21	known	know	VERB
cajgh-231	432	22	clinical	clinical	ADJ
cajgh-231	432	23	association	association	NOUN
cajgh-231	432	24	in	in	ADP
cajgh-231	432	25	need	need	NOUN
cajgh-231	432	26	of	of	ADP
cajgh-231	432	27	an	an	DET
cajgh-231	432	28	effective	effective	ADJ
cajgh-231	432	29	cure	cure	NOUN
cajgh-231	432	30	and	and	CCONJ
cajgh-231	432	31	explanation	explanation	NOUN
cajgh-231	432	32	.	.	PUNCT
cajgh-231	433	1	neurogastroenterol	neurogastroenterol	PROPN
cajgh-231	433	2	motil	motil	PROPN
cajgh-231	433	3	.	.	PUNCT
cajgh-231	434	1	vol	vol	NOUN
cajgh-231	434	2	20	20	NUM
cajgh-231	434	3	(	(	PUNCT
cajgh-231	434	4	7)2008:741	7)2008:741	NUM
cajgh-231	434	5	-	-	PUNCT
cajgh-231	434	6	749	749	NUM
cajgh-231	434	7	.	.	PUNCT
cajgh-231	434	8	80	80	NUM
cajgh-231	434	9	.	.	PUNCT
cajgh-231	434	10	creamer	creamer	NOUN
cajgh-231	434	11	b	b	PROPN
cajgh-231	434	12	,	,	PUNCT
cajgh-231	434	13	shorter	short	ADJ
cajgh-231	434	14	rg	rg	NOUN
cajgh-231	434	15	,	,	PUNCT
cajgh-231	434	16	bamforth	bamforth	NOUN
cajgh-231	434	17	j.	j.	PROPN
cajgh-231	434	18	the	the	DET
cajgh-231	434	19	turnover	turnover	NOUN
cajgh-231	434	20	and	and	CCONJ
cajgh-231	434	21	shedding	shedding	NOUN
cajgh-231	434	22	of	of	ADP
cajgh-231	434	23	epithelial	epithelial	ADJ
cajgh-231	434	24	cells	cell	NOUN
cajgh-231	434	25	.	.	PUNCT
cajgh-231	435	1	i.	i.	NOUN
cajgh-231	435	2	the	the	DET
cajgh-231	435	3	turnover	turnover	NOUN
cajgh-231	435	4	in	in	ADP
cajgh-231	435	5	the	the	DET
cajgh-231	435	6	gastro	gastro	ADJ
cajgh-231	435	7	-	-	PUNCT
cajgh-231	435	8	intestinal	intestinal	ADJ
cajgh-231	435	9	tract	tract	NOUN
cajgh-231	435	10	.	.	PUNCT
cajgh-231	436	1	gut	gut	NOUN
cajgh-231	436	2	.	.	PUNCT
cajgh-231	437	1	vol	vol	NOUN
cajgh-231	437	2	2	2	NUM
cajgh-231	437	3	(	(	PUNCT
cajgh-231	437	4	2)1961:110	2)1961:110	NUM
cajgh-231	437	5	-	-	SYM
cajgh-231	437	6	116	116	NUM
cajgh-231	437	7	.	.	PUNCT
cajgh-231	437	8	81	81	NUM
cajgh-231	437	9	.	.	PUNCT
cajgh-231	438	1	mouret	mouret	PROPN
cajgh-231	438	2	a	a	PRON
cajgh-231	438	3	,	,	PUNCT
cajgh-231	438	4	lepousez	lepousez	NOUN
cajgh-231	438	5	g	g	NOUN
cajgh-231	438	6	,	,	PUNCT
cajgh-231	438	7	gras	gras	PROPN
cajgh-231	438	8	j	j	PROPN
cajgh-231	438	9	,	,	PUNCT
cajgh-231	438	10	gabellec	gabellec	VERB
cajgh-231	438	11	mm	mm	PROPN
cajgh-231	438	12	,	,	PUNCT
cajgh-231	438	13	lledo	lledo	PROPN
cajgh-231	438	14	pm	pm	NOUN
cajgh-231	438	15	.	.	PUNCT
cajgh-231	439	1	turnover	turnover	NOUN
cajgh-231	439	2	of	of	ADP
cajgh-231	439	3	newborn	newborn	ADJ
cajgh-231	439	4	olfactory	olfactory	ADJ
cajgh-231	439	5	bulb	bulb	NOUN
cajgh-231	439	6	neurons	neuron	NOUN
cajgh-231	439	7	optimizes	optimize	VERB
cajgh-231	439	8	olfaction	olfaction	NOUN
cajgh-231	439	9	.	.	PUNCT
cajgh-231	440	1	j	j	PROPN
cajgh-231	440	2	neurosci	neurosci	PROPN
cajgh-231	440	3	.	.	PUNCT
cajgh-231	441	1	vol	vol	NOUN
cajgh-231	441	2	29	29	NUM
cajgh-231	441	3	(	(	PUNCT
cajgh-231	441	4	39)2009:12302	39)2009:12302	NUM
cajgh-231	441	5	-	-	SYM
cajgh-231	441	6	12314	12314	NUM
cajgh-231	441	7	.	.	PUNCT
cajgh-231	442	1	http://www.library.pitt.edu/	http://www.library.pitt.edu/	PROPN
cajgh-231	442	2	http://www.pitt.edu/	http://www.pitt.edu/	NOUN
cajgh-231	442	3	http://www.library.pitt.edu/articles/digpubtype/index.html	http://www.library.pitt.edu/articles/digpubtype/index.html	X
cajgh-231	443	1	http://www.upress.pitt.edu/upressindex.aspx	http://www.upress.pitt.edu/upressindex.aspx	PROPN
cajgh-231	443	2	the	the	DET
cajgh-231	443	3	universal	universal	ADJ
cajgh-231	443	4	non	non	ADJ
cajgh-231	443	5	-	-	ADJ
cajgh-231	443	6	neuronal	neuronal	ADJ
cajgh-231	443	7	nature	nature	NOUN
cajgh-231	443	8	of	of	ADP
cajgh-231	443	9	parkinson	parkinson	NOUN
cajgh-231	443	10	’s	’s	PART
cajgh-231	443	11	disease	disease	NOUN
cajgh-231	443	12	:	:	PUNCT
cajgh-231	443	13	a	a	DET
cajgh-231	443	14	theory	theory	NOUN
cajgh-231	443	15	abstract	abstract	ADJ
cajgh-231	443	16	keywords	keyword	NOUN
cajgh-231	443	17	:	:	PUNCT
cajgh-231	443	18	parkinson	parkinson	NOUN
cajgh-231	443	19	’s	’s	PART
cajgh-231	443	20	disease	disease	NOUN
cajgh-231	443	21	,	,	PUNCT
cajgh-231	443	22	the	the	DET
cajgh-231	443	23	universal	universal	ADJ
cajgh-231	443	24	non	non	ADJ
cajgh-231	443	25	-	-	ADJ
cajgh-231	443	26	neuronal	neuronal	ADJ
cajgh-231	443	27	nature	nature	NOUN
cajgh-231	443	28	of	of	ADP
cajgh-231	443	29	parkinson	parkinson	NOUN
cajgh-231	443	30	’s	’s	PART
cajgh-231	443	31	disease	disease	NOUN
cajgh-231	443	32	:	:	PUNCT
cajgh-231	443	33	a	a	DET
cajgh-231	443	34	theory	theory	NOUN
cajgh-231	443	35	research	research	NOUN