id	sid	tid	token	lemma	pos
cajgh-29	1	1	brca1	brca1	PROPN
cajgh-29	1	2	and	and	CCONJ
cajgh-29	1	3	brca2	brca2	PROPN
cajgh-29	1	4	gene	gene	NOUN
cajgh-29	1	5	mutations	mutation	NOUN
cajgh-29	1	6	screening	screen	VERB
cajgh-29	1	7	in	in	ADP
cajgh-29	1	8	sporadic	sporadic	ADJ
cajgh-29	1	9	breast	breast	NOUN
cajgh-29	1	10	cancer	cancer	NOUN
cajgh-29	1	11	patients	patient	NOUN
cajgh-29	1	12	in	in	ADP
cajgh-29	1	13	kazakhstan	kazakhstan	PROPN
cajgh-29	1	14	.	.	PUNCT
cajgh-29	2	1	brca1	brca1	PROPN
cajgh-29	2	2	and	and	CCONJ
cajgh-29	2	3	brca2	brca2	PROPN
cajgh-29	2	4	gene	gene	NOUN
cajgh-29	2	5	mutations	mutation	NOUN
cajgh-29	2	6	screening	screen	VERB
cajgh-29	2	7	in	in	ADP
cajgh-29	2	8	sporadic	sporadic	ADJ
cajgh-29	2	9	breast	breast	NOUN
cajgh-29	2	10	cancer	cancer	NOUN
cajgh-29	2	11	patients	patient	NOUN
cajgh-29	2	12	in	in	ADP
cajgh-29	2	13	kazakhstan	kazakhstan	PROPN
cajgh-29	2	14	.	.	PUNCT
cajgh-29	3	1	ainur	ainur	PROPN
cajgh-29	3	2	r.	r.	PROPN
cajgh-29	3	3	akilzhanova1,2	akilzhanova1,2	PROPN
cajgh-29	3	4	,	,	PUNCT
cajgh-29	3	5	bagdat	bagdat	PROPN
cajgh-29	3	6	nyshanbekkyzy2	nyshanbekkyzy2	PROPN
cajgh-29	3	7	,	,	PUNCT
cajgh-29	3	8	zhannur	zhannur	NOUN
cajgh-29	3	9	m.	m.	PROPN
cajgh-29	3	10	nurkina1,2	nurkina1,2	PROPN
cajgh-29	3	11	,	,	PUNCT
cajgh-29	3	12	ivan	ivan	PROPN
cajgh-29	3	13	i.	i.	PROPN
cajgh-29	3	14	shtephanov3	shtephanov3	PROPN
cajgh-29	3	15	,	,	PUNCT
cajgh-29	3	16	abay	abay	PROPN
cajgh-29	3	17	k.	k.	PROPN
cajgh-29	3	18	makishev3	makishev3	PROPN
cajgh-29	3	19	,	,	PUNCT
cajgh-29	3	20	tasbolat	tasbolat	PROPN
cajgh-29	3	21	a.	a.	NOUN
cajgh-29	3	22	adylkhanov4,5	adylkhanov4,5	PROPN
cajgh-29	3	23	,	,	PUNCT
cajgh-29	3	24	tolebay	tolebay	PROPN
cajgh-29	3	25	k.	k.	PROPN
cajgh-29	4	1	rakhypbekov4,5	rakhypbekov4,5	PROPN
cajgh-29	4	2	,	,	PUNCT
cajgh-29	4	3	erlan	erlan	ADJ
cajgh-29	4	4	m.	m.	NOUN
cajgh-29	4	5	ramanculov2	ramanculov2	PROPN
cajgh-29	4	6	,	,	PUNCT
cajgh-29	4	7	kuvat	kuvat	NOUN
cajgh-29	4	8	t.	t.	NOUN
cajgh-29	4	9	momynaliev2	momynaliev2	PROPN
cajgh-29	4	10	1center	1center	NUM
cajgh-29	4	11	for	for	ADP
cajgh-29	4	12	life	life	NOUN
cajgh-29	4	13	sciences	science	NOUN
cajgh-29	4	14	,	,	PUNCT
cajgh-29	4	15	nazarbayev	nazarbayev	ADJ
cajgh-29	4	16	university	university	NOUN
cajgh-29	4	17	,	,	PUNCT
cajgh-29	4	18	astana	astana	PROPN
cajgh-29	4	19	,	,	PUNCT
cajgh-29	4	20	kazakhstan	kazakhstan	PROPN
cajgh-29	4	21	;	;	PUNCT
cajgh-29	4	22	2national	2national	NUM
cajgh-29	4	23	center	center	NOUN
cajgh-29	4	24	for	for	ADP
cajgh-29	4	25	biotechnology	biotechnology	NOUN
cajgh-29	4	26	,	,	PUNCT
cajgh-29	4	27	astana	astana	PROPN
cajgh-29	4	28	,	,	PUNCT
cajgh-29	4	29	kazakhstan	kazakhstan	PROPN
cajgh-29	4	30	;	;	PUNCT
cajgh-29	4	31	3state	3state	NUM
cajgh-29	4	32	medical	medical	ADJ
cajgh-29	4	33	university	university	NOUN
cajgh-29	4	34	astana	astana	PROPN
cajgh-29	4	35	,	,	PUNCT
cajgh-29	4	36	astana	astana	PROPN
cajgh-29	4	37	oncological	oncological	ADJ
cajgh-29	4	38	center	center	NOUN
cajgh-29	4	39	,	,	PUNCT
cajgh-29	4	40	astana	astana	PROPN
cajgh-29	4	41	,	,	PUNCT
cajgh-29	4	42	kazakhstan	kazakhstan	PROPN
cajgh-29	4	43	;	;	PUNCT
cajgh-29	4	44	4semey	4semey	NUM
cajgh-29	4	45	oncological	oncological	ADJ
cajgh-29	4	46	center	center	NOUN
cajgh-29	4	47	,	,	PUNCT
cajgh-29	4	48	semey	semey	PROPN
cajgh-29	4	49	,	,	PUNCT
cajgh-29	4	50	kazakhstan	kazakhstan	PROPN
cajgh-29	4	51	;	;	PUNCT
cajgh-29	4	52	5semey	5semey	NUM
cajgh-29	4	53	state	state	NOUN
cajgh-29	4	54	medical	medical	ADJ
cajgh-29	4	55	university	university	NOUN
cajgh-29	4	56	,	,	PUNCT
cajgh-29	4	57	semey	semey	PROPN
cajgh-29	4	58	,	,	PUNCT
cajgh-29	4	59	kazakhstan	kazakhstan	PROPN
cajgh-29	4	60	abstract	abstract	ADJ
cajgh-29	4	61	background	background	NOUN
cajgh-29	4	62	:	:	PUNCT
cajgh-29	4	63	a	a	DET
cajgh-29	4	64	large	large	ADJ
cajgh-29	4	65	number	number	NOUN
cajgh-29	4	66	of	of	ADP
cajgh-29	4	67	distinct	distinct	ADJ
cajgh-29	4	68	mutations	mutation	NOUN
cajgh-29	4	69	in	in	ADP
cajgh-29	4	70	the	the	DET
cajgh-29	4	71	brca1	brca1	NOUN
cajgh-29	4	72	and	and	CCONJ
cajgh-29	4	73	brca2	brca2	NOUN
cajgh-29	4	74	genes	gene	NOUN
cajgh-29	4	75	have	have	AUX
cajgh-29	4	76	been	be	AUX
cajgh-29	4	77	reported	report	VERB
cajgh-29	4	78	worldwide	worldwide	ADV
cajgh-29	4	79	,	,	PUNCT
cajgh-29	4	80	but	but	CCONJ
cajgh-29	4	81	little	little	ADJ
cajgh-29	4	82	is	be	AUX
cajgh-29	4	83	known	know	VERB
cajgh-29	4	84	regarding	regard	VERB
cajgh-29	4	85	the	the	DET
cajgh-29	4	86	role	role	NOUN
cajgh-29	4	87	of	of	ADP
cajgh-29	4	88	these	these	DET
cajgh-29	4	89	inherited	inherit	VERB
cajgh-29	4	90	susceptibility	susceptibility	NOUN
cajgh-29	4	91	genes	gene	NOUN
cajgh-29	4	92	in	in	ADP
cajgh-29	4	93	breast	breast	NOUN
cajgh-29	4	94	cancer	cancer	NOUN
cajgh-29	4	95	risk	risk	NOUN
cajgh-29	4	96	among	among	ADP
cajgh-29	4	97	kazakhstan	kazakhstan	PROPN
cajgh-29	4	98	women	woman	NOUN
cajgh-29	4	99	.	.	PUNCT
cajgh-29	5	1	aim	aim	VERB
cajgh-29	5	2	:	:	PUNCT
cajgh-29	5	3	to	to	PART
cajgh-29	5	4	evaluate	evaluate	VERB
cajgh-29	5	5	the	the	DET
cajgh-29	5	6	role	role	NOUN
cajgh-29	5	7	of	of	ADP
cajgh-29	5	8	brca1/2	brca1/2	ADJ
cajgh-29	5	9	mutations	mutation	NOUN
cajgh-29	5	10	in	in	ADP
cajgh-29	5	11	kazakhstan	kazakhstan	PROPN
cajgh-29	5	12	women	woman	NOUN
cajgh-29	5	13	presenting	present	VERB
cajgh-29	5	14	with	with	ADP
cajgh-29	5	15	sporadic	sporadic	ADJ
cajgh-29	5	16	breast	breast	NOUN
cajgh-29	5	17	cancer	cancer	NOUN
cajgh-29	5	18	.	.	PUNCT
cajgh-29	6	1	methods	method	NOUN
cajgh-29	6	2	:	:	PUNCT
cajgh-29	6	3	we	we	PRON
cajgh-29	6	4	investigated	investigate	VERB
cajgh-29	6	5	the	the	DET
cajgh-29	6	6	distribution	distribution	NOUN
cajgh-29	6	7	and	and	CCONJ
cajgh-29	6	8	nature	nature	NOUN
cajgh-29	6	9	of	of	ADP
cajgh-29	6	10	polymorphisms	polymorphism	NOUN
cajgh-29	6	11	in	in	ADP
cajgh-29	6	12	brca1	brca1	PROPN
cajgh-29	6	13	and	and	CCONJ
cajgh-29	6	14	brca2	brca2	PROPN
cajgh-29	6	15	entire	entire	VERB
cajgh-29	6	16	coding	code	VERB
cajgh-29	6	17	regions	region	NOUN
cajgh-29	6	18	in	in	ADP
cajgh-29	6	19	156	156	NUM
cajgh-29	6	20	kazakhstan	kazakhstan	PROPN
cajgh-29	6	21	sporadic	sporadic	ADJ
cajgh-29	6	22	breast	breast	NOUN
cajgh-29	6	23	cancer	cancer	NOUN
cajgh-29	6	24	cases	case	NOUN
cajgh-29	6	25	and	and	CCONJ
cajgh-29	6	26	112	112	NUM
cajgh-29	6	27	age	age	NOUN
cajgh-29	6	28	-	-	PUNCT
cajgh-29	6	29	matched	match	VERB
cajgh-29	6	30	controls	control	NOUN
cajgh-29	6	31	using	use	VERB
cajgh-29	6	32	automatic	automatic	ADJ
cajgh-29	6	33	direct	direct	ADJ
cajgh-29	6	34	sequencing	sequencing	NOUN
cajgh-29	6	35	.	.	PUNCT
cajgh-29	7	1	results	result	NOUN
cajgh-29	7	2	:	:	PUNCT
cajgh-29	7	3	we	we	PRON
cajgh-29	7	4	identified	identify	VERB
cajgh-29	7	5	22	22	NUM
cajgh-29	7	6	distinct	distinct	ADJ
cajgh-29	7	7	variants	variant	NOUN
cajgh-29	7	8	,	,	PUNCT
cajgh-29	7	9	including	include	VERB
cajgh-29	7	10	16	16	NUM
cajgh-29	7	11	missense	missense	NOUN
cajgh-29	7	12	mutations	mutation	NOUN
cajgh-29	7	13	and	and	CCONJ
cajgh-29	7	14	6	6	NUM
cajgh-29	7	15	polymorphisms	polymorphism	NOUN
cajgh-29	7	16	in	in	ADP
cajgh-29	7	17	brca1/2	brca1/2	ADJ
cajgh-29	7	18	genes	gene	NOUN
cajgh-29	7	19	.	.	PUNCT
cajgh-29	8	1	in	in	ADP
cajgh-29	8	2	brca1	brca1	PROPN
cajgh-29	8	3	,	,	PUNCT
cajgh-29	8	4	9	9	NUM
cajgh-29	8	5	missense	missense	NOUN
cajgh-29	8	6	mutations	mutation	NOUN
cajgh-29	8	7	and	and	CCONJ
cajgh-29	8	8	3	3	NUM
cajgh-29	8	9	synonymous	synonymous	ADJ
cajgh-29	8	10	polymorphisms	polymorphism	NOUN
cajgh-29	8	11	were	be	AUX
cajgh-29	8	12	observed	observe	VERB
cajgh-29	8	13	.	.	PUNCT
cajgh-29	9	1	in	in	ADP
cajgh-29	9	2	brca2	brca2	PROPN
cajgh-29	9	3	,	,	PUNCT
cajgh-29	9	4	7	7	NUM
cajgh-29	9	5	missense	missense	NOUN
cajgh-29	9	6	mutations	mutation	NOUN
cajgh-29	9	7	and	and	CCONJ
cajgh-29	9	8	3	3	NUM
cajgh-29	9	9	polymorphisms	polymorphism	NOUN
cajgh-29	9	10	were	be	AUX
cajgh-29	9	11	detected	detect	VERB
cajgh-29	9	12	.	.	PUNCT
cajgh-29	10	1	there	there	PRON
cajgh-29	10	2	was	be	VERB
cajgh-29	10	3	a	a	DET
cajgh-29	10	4	higher	high	ADJ
cajgh-29	10	5	prevalence	prevalence	NOUN
cajgh-29	10	6	of	of	ADP
cajgh-29	10	7	observed	observed	ADJ
cajgh-29	10	8	mutations	mutation	NOUN
cajgh-29	10	9	in	in	ADP
cajgh-29	10	10	caucasian	caucasian	ADJ
cajgh-29	10	11	breast	breast	NOUN
cajgh-29	10	12	cancer	cancer	NOUN
cajgh-29	10	13	cases	case	NOUN
cajgh-29	10	14	compared	compare	VERB
cajgh-29	10	15	to	to	ADP
cajgh-29	10	16	asian	asian	ADJ
cajgh-29	10	17	cases	case	NOUN
cajgh-29	10	18	(	(	PUNCT
cajgh-29	10	19	p<0.05	p<0.05	NOUN
cajgh-29	10	20	)	)	PUNCT
cajgh-29	10	21	;	;	PUNCT
cajgh-29	10	22	higher	high	ADJ
cajgh-29	10	23	frequencies	frequency	NOUN
cajgh-29	10	24	of	of	ADP
cajgh-29	10	25	sequence	sequence	NOUN
cajgh-29	10	26	variants	variant	NOUN
cajgh-29	10	27	were	be	AUX
cajgh-29	10	28	observed	observe	VERB
cajgh-29	10	29	in	in	ADP
cajgh-29	10	30	asian	asian	ADJ
cajgh-29	10	31	controls	control	NOUN
cajgh-29	10	32	.	.	PUNCT
cajgh-29	11	1	no	no	DET
cajgh-29	11	2	recurrent	recurrent	NOUN
cajgh-29	11	3	or	or	CCONJ
cajgh-29	11	4	founder	founder	NOUN
cajgh-29	11	5	mutations	mutation	NOUN
cajgh-29	11	6	were	be	AUX
cajgh-29	11	7	observed	observe	VERB
cajgh-29	11	8	in	in	ADP
cajgh-29	11	9	brca1/2	brca1/2	ADJ
cajgh-29	11	10	genes	gene	NOUN
cajgh-29	11	11	.	.	PUNCT
cajgh-29	12	1	there	there	PRON
cajgh-29	12	2	were	be	VERB
cajgh-29	12	3	no	no	DET
cajgh-29	12	4	statistically	statistically	ADV
cajgh-29	12	5	significant	significant	ADJ
cajgh-29	12	6	differences	difference	NOUN
cajgh-29	12	7	in	in	ADP
cajgh-29	12	8	age	age	NOUN
cajgh-29	12	9	at	at	ADP
cajgh-29	12	10	diagnosis	diagnosis	NOUN
cajgh-29	12	11	,	,	PUNCT
cajgh-29	12	12	tumor	tumor	NOUN
cajgh-29	12	13	histology	histology	NOUN
cajgh-29	12	14	,	,	PUNCT
cajgh-29	12	15	size	size	NOUN
cajgh-29	12	16	of	of	ADP
cajgh-29	12	17	tumor	tumor	NOUN
cajgh-29	12	18	,	,	PUNCT
cajgh-29	12	19	and	and	CCONJ
cajgh-29	12	20	lymph	lymph	NOUN
cajgh-29	12	21	node	node	NOUN
cajgh-29	12	22	involvement	involvement	NOUN
cajgh-29	12	23	between	between	ADP
cajgh-29	12	24	women	woman	NOUN
cajgh-29	12	25	with	with	ADP
cajgh-29	12	26	breast	breast	NOUN
cajgh-29	12	27	cancer	cancer	NOUN
cajgh-29	12	28	with	with	ADP
cajgh-29	12	29	or	or	CCONJ
cajgh-29	12	30	without	without	ADP
cajgh-29	12	31	the	the	DET
cajgh-29	12	32	brca	brca	PROPN
cajgh-29	12	33	sequence	sequence	NOUN
cajgh-29	12	34	alterations	alteration	NOUN
cajgh-29	12	35	.	.	PUNCT
cajgh-29	13	1	conclusions	conclusion	NOUN
cajgh-29	13	2	:	:	PUNCT
cajgh-29	13	3	considering	consider	VERB
cajgh-29	13	4	the	the	DET
cajgh-29	13	5	majority	majority	NOUN
cajgh-29	13	6	of	of	ADP
cajgh-29	13	7	breast	breast	NOUN
cajgh-29	13	8	cancer	cancer	NOUN
cajgh-29	13	9	cases	case	NOUN
cajgh-29	13	10	are	be	AUX
cajgh-29	13	11	sporadic	sporadic	ADJ
cajgh-29	13	12	,	,	PUNCT
cajgh-29	13	13	the	the	DET
cajgh-29	13	14	present	present	ADJ
cajgh-29	13	15	study	study	NOUN
cajgh-29	13	16	will	will	AUX
cajgh-29	13	17	be	be	AUX
cajgh-29	13	18	helpful	helpful	ADJ
cajgh-29	13	19	in	in	ADP
cajgh-29	13	20	the	the	DET
cajgh-29	13	21	evaluation	evaluation	NOUN
cajgh-29	13	22	of	of	ADP
cajgh-29	13	23	the	the	DET
cajgh-29	13	24	need	need	NOUN
cajgh-29	13	25	for	for	ADP
cajgh-29	13	26	the	the	DET
cajgh-29	13	27	genetic	genetic	ADJ
cajgh-29	13	28	screening	screening	NOUN
cajgh-29	13	29	of	of	ADP
cajgh-29	13	30	brca1/2	brca1/2	ADJ
cajgh-29	13	31	mutations	mutation	NOUN
cajgh-29	13	32	and	and	CCONJ
cajgh-29	13	33	reliable	reliable	ADJ
cajgh-29	13	34	genetic	genetic	ADJ
cajgh-29	13	35	counseling	counseling	NOUN
cajgh-29	13	36	for	for	ADP
cajgh-29	13	37	kazakhstan	kazakhstan	PROPN
cajgh-29	13	38	sporadic	sporadic	ADJ
cajgh-29	13	39	breast	breast	NOUN
cajgh-29	13	40	cancer	cancer	NOUN
cajgh-29	13	41	patients	patient	NOUN
cajgh-29	13	42	.	.	PUNCT
cajgh-29	14	1	evaluation	evaluation	NOUN
cajgh-29	14	2	of	of	ADP
cajgh-29	14	3	common	common	ADJ
cajgh-29	14	4	polymorphisms	polymorphism	NOUN
cajgh-29	14	5	and	and	CCONJ
cajgh-29	14	6	mutations	mutation	NOUN
cajgh-29	14	7	and	and	CCONJ
cajgh-29	14	8	breast	breast	NOUN
cajgh-29	14	9	cancer	cancer	NOUN
cajgh-29	14	10	risk	risk	NOUN
cajgh-29	14	11	in	in	ADP
cajgh-29	14	12	families	family	NOUN
cajgh-29	14	13	with	with	ADP
cajgh-29	14	14	genetic	genetic	ADJ
cajgh-29	14	15	predisposition	predisposition	NOUN
cajgh-29	14	16	to	to	ADP
cajgh-29	14	17	breast	breast	NOUN
cajgh-29	14	18	cancer	cancer	NOUN
cajgh-29	14	19	is	be	AUX
cajgh-29	14	20	ongoing	ongoing	ADJ
cajgh-29	14	21	in	in	ADP
cajgh-29	14	22	another	another	DET
cajgh-29	14	23	current	current	ADJ
cajgh-29	14	24	investigation	investigation	NOUN
cajgh-29	14	25	.	.	PUNCT
cajgh-29	15	1	introduction	introduction	NOUN
cajgh-29	15	2	breast	breast	NOUN
cajgh-29	15	3	cancer	cancer	NOUN
cajgh-29	15	4	is	be	AUX
cajgh-29	15	5	the	the	DET
cajgh-29	15	6	most	most	ADV
cajgh-29	15	7	common	common	ADJ
cajgh-29	15	8	malignancy	malignancy	NOUN
cajgh-29	15	9	in	in	ADP
cajgh-29	15	10	females	female	NOUN
cajgh-29	15	11	and	and	CCONJ
cajgh-29	15	12	one	one	NUM
cajgh-29	15	13	of	of	ADP
cajgh-29	15	14	the	the	DET
cajgh-29	15	15	leading	lead	VERB
cajgh-29	15	16	causes	cause	NOUN
cajgh-29	15	17	of	of	ADP
cajgh-29	15	18	death	death	NOUN
cajgh-29	15	19	from	from	ADP
cajgh-29	15	20	cancer	cancer	NOUN
cajgh-29	15	21	in	in	ADP
cajgh-29	15	22	women	woman	NOUN
cajgh-29	15	23	worldwide.1	worldwide.1	SCONJ
cajgh-29	15	24	it	it	PRON
cajgh-29	15	25	accounts	account	VERB
cajgh-29	15	26	for	for	ADP
cajgh-29	15	27	23	23	NUM
cajgh-29	15	28	%	%	NOUN
cajgh-29	15	29	of	of	ADP
cajgh-29	15	30	all	all	DET
cajgh-29	15	31	cancers	cancer	NOUN
cajgh-29	15	32	among	among	ADP
cajgh-29	15	33	women	woman	NOUN
cajgh-29	15	34	and	and	CCONJ
cajgh-29	15	35	is	be	AUX
cajgh-29	15	36	the	the	DET
cajgh-29	15	37	second	second	ADJ
cajgh-29	15	38	most	most	ADV
cajgh-29	15	39	common	common	ADJ
cajgh-29	15	40	cancer	cancer	NOUN
cajgh-29	15	41	overall	overall	NOUN
cajgh-29	15	42	when	when	SCONJ
cajgh-29	15	43	both	both	DET
cajgh-29	15	44	sexes	sex	NOUN
cajgh-29	15	45	are	be	AUX
cajgh-29	15	46	considered	consider	VERB
cajgh-29	15	47	.	.	PUNCT
cajgh-29	16	1	breast	breast	NOUN
cajgh-29	16	2	cancer	cancer	NOUN
cajgh-29	16	3	showed	show	VERB
cajgh-29	16	4	the	the	DET
cajgh-29	16	5	biggest	big	ADJ
cajgh-29	16	6	proportional	proportional	ADJ
cajgh-29	16	7	increase	increase	NOUN
cajgh-29	16	8	in	in	ADP
cajgh-29	16	9	the	the	DET
cajgh-29	16	10	number	number	NOUN
cajgh-29	16	11	of	of	ADP
cajgh-29	16	12	new	new	ADJ
cajgh-29	16	13	cases	case	NOUN
cajgh-29	16	14	in	in	ADP
cajgh-29	16	15	women	woman	NOUN
cajgh-29	16	16	from	from	ADP
cajgh-29	16	17	2006	2006	NUM
cajgh-29	16	18	-	-	SYM
cajgh-29	16	19	2011	2011	NUM
cajgh-29	16	20	and	and	CCONJ
cajgh-29	16	21	remains	remain	VERB
cajgh-29	16	22	the	the	DET
cajgh-29	16	23	leading	lead	VERB
cajgh-29	16	24	form	form	NOUN
cajgh-29	16	25	of	of	ADP
cajgh-29	16	26	cancer	cancer	NOUN
cajgh-29	16	27	in	in	ADP
cajgh-29	16	28	women	woman	NOUN
cajgh-29	16	29	in	in	ADP
cajgh-29	16	30	kazakhstan.2	kazakhstan.2	PROPN
cajgh-29	16	31	germline	germline	NOUN
cajgh-29	16	32	mutations	mutation	NOUN
cajgh-29	16	33	in	in	ADP
cajgh-29	16	34	brca1	brca1	PROPN
cajgh-29	16	35	and	and	CCONJ
cajgh-29	16	36	brca2	brca2	NOUN
cajgh-29	16	37	genes	gene	NOUN
cajgh-29	16	38	account	account	VERB
cajgh-29	16	39	for	for	ADP
cajgh-29	16	40	genetic	genetic	ADJ
cajgh-29	16	41	predisposition	predisposition	NOUN
cajgh-29	16	42	and	and	CCONJ
cajgh-29	16	43	increased	increase	VERB
cajgh-29	16	44	risk	risk	NOUN
cajgh-29	16	45	of	of	ADP
cajgh-29	16	46	breast	breast	NOUN
cajgh-29	16	47	and	and	CCONJ
cajgh-29	16	48	ovarian	ovarian	ADJ
cajgh-29	16	49	cancers.3	cancers.3	PROPN
cajgh-29	16	50	two	two	NUM
cajgh-29	16	51	major	major	ADJ
cajgh-29	16	52	breast	breast	NOUN
cajgh-29	16	53	cancer	cancer	NOUN
cajgh-29	16	54	susceptibility	susceptibility	NOUN
cajgh-29	16	55	genes	gene	NOUN
cajgh-29	16	56	are	be	AUX
cajgh-29	16	57	brca1	brca1	NOUN
cajgh-29	16	58	(	(	PUNCT
cajgh-29	16	59	mim	mim	PROPN
cajgh-29	16	60	113705	113705	NUM
cajgh-29	16	61	,	,	PUNCT
cajgh-29	16	62	genbank	genbank	NOUN
cajgh-29	16	63	accession	accession	NOUN
cajgh-29	16	64	no	no	INTJ
cajgh-29	16	65	.	.	PUNCT
cajgh-29	17	1	u14680	u14680	PROPN
cajgh-29	17	2	)	)	PUNCT
cajgh-29	17	3	and	and	CCONJ
cajgh-29	17	4	brca2	brca2	PROPN
cajgh-29	17	5	(	(	PUNCT
cajgh-29	17	6	mim	mim	PROPN
cajgh-29	17	7	600185	600185	NUM
cajgh-29	17	8	,	,	PUNCT
cajgh-29	17	9	genbank	genbank	NOUN
cajgh-29	17	10	accession	accession	NOUN
cajgh-29	17	11	no	no	INTJ
cajgh-29	17	12	.	.	PUNCT
cajgh-29	18	1	u43746	u43746	NOUN
cajgh-29	18	2	)	)	PUNCT
cajgh-29	18	3	,	,	PUNCT
cajgh-29	19	1	located	locate	VERB
cajgh-29	19	2	on	on	ADP
cajgh-29	19	3	the	the	DET
cajgh-29	19	4	long	long	ADJ
cajgh-29	19	5	arms	arm	NOUN
cajgh-29	19	6	of	of	ADP
cajgh-29	19	7	chromosomes	chromosome	NOUN
cajgh-29	19	8	174	174	NUM
cajgh-29	19	9	and	and	CCONJ
cajgh-29	19	10	13,5	13,5	NUM
cajgh-29	19	11	respectively	respectively	ADV
cajgh-29	19	12	,	,	PUNCT
cajgh-29	19	13	and	and	CCONJ
cajgh-29	19	14	both	both	PRON
cajgh-29	19	15	apparently	apparently	ADV
cajgh-29	19	16	function	function	VERB
cajgh-29	19	17	as	as	ADP
cajgh-29	19	18	tumor	tumor	NOUN
cajgh-29	19	19	suppressor	suppressor	NOUN
cajgh-29	19	20	genes	gene	NOUN
cajgh-29	19	21	.	.	PUNCT
cajgh-29	20	1	brca1	brca1	PROPN
cajgh-29	20	2	is	be	AUX
cajgh-29	20	3	a	a	DET
cajgh-29	20	4	large	large	ADJ
cajgh-29	20	5	protein	protein	NOUN
cajgh-29	20	6	of	of	ADP
cajgh-29	20	7	1863	1863	NUM
cajgh-29	20	8	amino	amino	NOUN
cajgh-29	20	9	acids	acid	NOUN
cajgh-29	20	10	and	and	CCONJ
cajgh-29	20	11	brca2	brca2	PROPN
cajgh-29	20	12	,	,	PUNCT
cajgh-29	20	13	with	with	ADP
cajgh-29	20	14	3418	3418	NUM
cajgh-29	20	15	amino	amino	NOUN
cajgh-29	20	16	acids	acid	NOUN
cajgh-29	20	17	,	,	PUNCT
cajgh-29	20	18	is	be	AUX
cajgh-29	20	19	even	even	ADV
cajgh-29	20	20	larger	large	ADJ
cajgh-29	20	21	.	.	PUNCT
cajgh-29	21	1	both	both	DET
cajgh-29	21	2	proteins	protein	NOUN
cajgh-29	21	3	are	be	AUX
cajgh-29	21	4	involved	involve	VERB
cajgh-29	21	5	in	in	ADP
cajgh-29	21	6	the	the	DET
cajgh-29	21	7	control	control	NOUN
cajgh-29	21	8	of	of	ADP
cajgh-29	21	9	homologous	homologous	ADJ
cajgh-29	21	10	recombination	recombination	NOUN
cajgh-29	21	11	(	(	PUNCT
cajgh-29	21	12	hr	hr	NOUN
cajgh-29	21	13	)	)	PUNCT
cajgh-29	21	14	and	and	CCONJ
cajgh-29	21	15	double	double	ADJ
cajgh-29	21	16	-	-	PUNCT
cajgh-29	21	17	strand	strand	NOUN
cajgh-29	21	18	break	break	NOUN
cajgh-29	21	19	repair	repair	NOUN
cajgh-29	21	20	in	in	ADP
cajgh-29	21	21	response	response	NOUN
cajgh-29	21	22	to	to	ADP
cajgh-29	21	23	dna	dna	PROPN
cajgh-29	21	24	damage.6	damage.6	NOUN
cajgh-29	21	25	-	-	SYM
cajgh-29	21	26	11	11	NUM
cajgh-29	21	27	brca1/2	brca1/2	NOUN
cajgh-29	21	28	have	have	AUX
cajgh-29	21	29	been	be	AUX
cajgh-29	21	30	shown	show	VERB
cajgh-29	21	31	to	to	PART
cajgh-29	21	32	serve	serve	VERB
cajgh-29	21	33	as	as	ADP
cajgh-29	21	34	important	important	ADJ
cajgh-29	21	35	central	central	ADJ
cajgh-29	21	36	components	component	NOUN
cajgh-29	21	37	in	in	ADP
cajgh-29	21	38	multiple	multiple	ADJ
cajgh-29	21	39	biological	biological	ADJ
cajgh-29	21	40	pathways	pathway	NOUN
cajgh-29	21	41	that	that	PRON
cajgh-29	21	42	regulate	regulate	VERB
cajgh-29	21	43	cell	cell	NOUN
cajgh-29	21	44	-	-	PUNCT
cajgh-29	21	45	cycle	cycle	NOUN
cajgh-29	21	46	progression	progression	NOUN
cajgh-29	21	47	,	,	PUNCT
cajgh-29	21	48	centrosome	centrosome	NOUN
cajgh-29	21	49	duplication	duplication	NOUN
cajgh-29	21	50	,	,	PUNCT
cajgh-29	21	51	dna	dna	PROPN
cajgh-29	21	52	damage	damage	NOUN
cajgh-29	21	53	repair	repair	NOUN
cajgh-29	21	54	,	,	PUNCT
cajgh-29	21	55	cell	cell	NOUN
cajgh-29	21	56	growth	growth	NOUN
cajgh-29	21	57	,	,	PUNCT
cajgh-29	21	58	and	and	CCONJ
cajgh-29	21	59	apoptosis.12	apoptosis.12	VERB
cajgh-29	21	60	evidence	evidence	NOUN
cajgh-29	21	61	that	that	SCONJ
cajgh-29	21	62	the	the	DET
cajgh-29	21	63	loss	loss	NOUN
cajgh-29	21	64	of	of	ADP
cajgh-29	21	65	brca1	brca1	PROPN
cajgh-29	21	66	alleles	allele	NOUN
cajgh-29	21	67	or	or	CCONJ
cajgh-29	21	68	low	low	ADJ
cajgh-29	21	69	expression	expression	NOUN
cajgh-29	21	70	of	of	ADP
cajgh-29	21	71	brca1	brca1	PROPN
cajgh-29	21	72	in	in	ADP
cajgh-29	21	73	a	a	DET
cajgh-29	21	74	large	large	ADJ
cajgh-29	21	75	proportion	proportion	NOUN
cajgh-29	21	76	of	of	ADP
cajgh-29	21	77	sporadic	sporadic	ADJ
cajgh-29	21	78	breast	breast	NOUN
cajgh-29	21	79	cancer	cancer	NOUN
cajgh-29	21	80	cases	case	NOUN
cajgh-29	21	81	supports	support	VERB
cajgh-29	21	82	the	the	DET
cajgh-29	21	83	role	role	NOUN
cajgh-29	21	84	of	of	ADP
cajgh-29	21	85	brca1	brca1	PROPN
cajgh-29	21	86	in	in	ADP
cajgh-29	21	87	the	the	DET
cajgh-29	21	88	development	development	NOUN
cajgh-29	21	89	of	of	ADP
cajgh-29	21	90	sporadic	sporadic	ADJ
cajgh-29	21	91	breast	breast	NOUN
cajgh-29	21	92	cancer.13	cancer.13	PROPN
cajgh-29	21	93	-	-	PUNCT
cajgh-29	21	94	15	15	NUM
cajgh-29	21	95	genetic	genetic	ADJ
cajgh-29	21	96	linkage	linkage	NOUN
cajgh-29	21	97	analysis4	analysis4	NOUN
cajgh-29	21	98	and	and	CCONJ
cajgh-29	21	99	refine	refine	VERB
cajgh-29	21	100	mapping16,17	mapping16,17	NOUN
cajgh-29	21	101	provided	provide	VERB
cajgh-29	21	102	the	the	DET
cajgh-29	21	103	evidence	evidence	NOUN
cajgh-29	21	104	of	of	ADP
cajgh-29	21	105	the	the	DET
cajgh-29	21	106	location	location	NOUN
cajgh-29	21	107	of	of	ADP
cajgh-29	21	108	penetrance	penetrance	NOUN
cajgh-29	21	109	as	as	ADP
cajgh-29	21	110	having	have	VERB
cajgh-29	21	111	a	a	DET
cajgh-29	21	112	germline	germline	NOUN
cajgh-29	21	113	mutation	mutation	NOUN
cajgh-29	21	114	;	;	PUNCT
cajgh-29	21	115	it	it	PRON
cajgh-29	21	116	was	be	AUX
cajgh-29	21	117	found	find	VERB
cajgh-29	21	118	that	that	SCONJ
cajgh-29	21	119	the	the	DET
cajgh-29	21	120	most	most	ADV
cajgh-29	21	121	commonly	commonly	ADV
cajgh-29	21	122	encountered	encounter	VERB
cajgh-29	21	123	sporadic	sporadic	ADJ
cajgh-29	21	124	forms	form	NOUN
cajgh-29	21	125	of	of	ADP
cajgh-29	21	126	breast	breast	NOUN
cajgh-29	21	127	cancer	cancer	NOUN
cajgh-29	21	128	vary	vary	VERB
cajgh-29	21	129	among	among	ADP
cajgh-29	21	130	different	different	ADJ
cajgh-29	21	131	populations.18	populations.18	NOUN
cajgh-29	21	132	-	-	PUNCT
cajgh-29	21	133	20	20	NUM
cajgh-29	21	134	this	this	DET
cajgh-29	21	135	contributory	contributory	NOUN
cajgh-29	21	136	variation	variation	NOUN
cajgh-29	21	137	may	may	AUX
cajgh-29	21	138	be	be	AUX
cajgh-29	21	139	attributed	attribute	VERB
cajgh-29	21	140	to	to	ADP
cajgh-29	21	141	their	their	PRON
cajgh-29	21	142	different	different	ADJ
cajgh-29	21	143	gene	gene	NOUN
cajgh-29	21	144	pool	pool	NOUN
cajgh-29	21	145	make	make	VERB
cajgh-29	21	146	and	and	CCONJ
cajgh-29	21	147	also	also	ADV
cajgh-29	21	148	due	due	ADJ
cajgh-29	21	149	to	to	ADP
cajgh-29	21	150	low	low	ADJ
cajgh-29	21	151	penetrance	penetrance	NOUN
cajgh-29	21	152	gene	gene	NOUN
cajgh-29	21	153	involvement	involvement	NOUN
cajgh-29	21	154	.	.	PUNCT
cajgh-29	22	1	however	however	ADV
cajgh-29	22	2	,	,	PUNCT
cajgh-29	22	3	some	some	DET
cajgh-29	22	4	studies	study	NOUN
cajgh-29	22	5	have	have	AUX
cajgh-29	22	6	pointed	point	VERB
cajgh-29	22	7	out	out	ADP
cajgh-29	22	8	that	that	SCONJ
cajgh-29	22	9	germline	germline	VERB
cajgh-29	22	10	mutations	mutation	NOUN
cajgh-29	22	11	in	in	ADP
cajgh-29	22	12	brca1/2	brca1/2	PROPN
cajgh-29	22	13	contribute	contribute	VERB
cajgh-29	22	14	little	little	ADJ
cajgh-29	22	15	to	to	ADP
cajgh-29	22	16	the	the	DET
cajgh-29	22	17	induction	induction	NOUN
cajgh-29	22	18	of	of	ADP
cajgh-29	22	19	breast	breast	NOUN
cajgh-29	22	20	cancer	cancer	NOUN
cajgh-29	22	21	in	in	ADP
cajgh-29	22	22	some	some	DET
cajgh-29	22	23	countries.21,22	countries.21,22	NOUN
cajgh-29	22	24	mutations	mutation	NOUN
cajgh-29	22	25	in	in	ADP
cajgh-29	22	26	the	the	DET
cajgh-29	22	27	brca1	brca1	NOUN
cajgh-29	22	28	and	and	CCONJ
cajgh-29	22	29	brca2	brca2	NOUN
cajgh-29	22	30	genes	gene	NOUN
cajgh-29	22	31	were	be	AUX
cajgh-29	22	32	first	first	ADV
cajgh-29	22	33	reported	report	VERB
cajgh-29	22	34	in	in	ADP
cajgh-29	22	35	conjunction	conjunction	NOUN
cajgh-29	22	36	with	with	ADP
cajgh-29	22	37	their	their	PRON
cajgh-29	22	38	identification	identification	NOUN
cajgh-29	22	39	in	in	ADP
cajgh-29	22	40	199423	199423	NUM
cajgh-29	22	41	and	and	CCONJ
cajgh-29	22	42	1995.24,25	1995.24,25	NUM
cajgh-29	22	43	during	during	ADP
cajgh-29	22	44	last	last	ADJ
cajgh-29	22	45	decade	decade	NOUN
cajgh-29	22	46	brca1	brca1	PROPN
cajgh-29	22	47	and	and	CCONJ
cajgh-29	22	48	brca2	brca2	PROPN
cajgh-29	22	49	have	have	AUX
cajgh-29	22	50	been	be	AUX
cajgh-29	22	51	extensively	extensively	ADV
cajgh-29	22	52	screened	screen	VERB
cajgh-29	22	53	for	for	ADP
cajgh-29	22	54	mutations	mutation	NOUN
cajgh-29	22	55	;	;	PUNCT
cajgh-29	22	56	numerous	numerous	ADJ
cajgh-29	22	57	mutations	mutation	NOUN
cajgh-29	22	58	have	have	AUX
cajgh-29	22	59	been	be	AUX
cajgh-29	22	60	reported	report	VERB
cajgh-29	22	61	to	to	PART
cajgh-29	22	62	be	be	AUX
cajgh-29	22	63	clearly	clearly	ADV
cajgh-29	22	64	associated	associate	VERB
cajgh-29	22	65	with	with	ADP
cajgh-29	22	66	cancer	cancer	NOUN
cajgh-29	22	67	susceptibility	susceptibility	NOUN
cajgh-29	22	68	and	and	CCONJ
cajgh-29	22	69	have	have	AUX
cajgh-29	22	70	been	be	AUX
cajgh-29	22	71	registered	register	VERB
cajgh-29	22	72	in	in	ADP
cajgh-29	22	73	the	the	DET
cajgh-29	22	74	breast	breast	NOUN
cajgh-29	22	75	cancer	cancer	NOUN
cajgh-29	22	76	information	information	NOUN
cajgh-29	22	77	core	core	NOUN
cajgh-29	22	78	database	database	NOUN
cajgh-29	22	79	(	(	PUNCT
cajgh-29	22	80	bic).26	bic).26	VERB
cajgh-29	22	81	most	most	ADJ
cajgh-29	22	82	of	of	ADP
cajgh-29	22	83	these	these	PRON
cajgh-29	22	84	are	be	AUX
cajgh-29	22	85	frameshift	frameshift	ADJ
cajgh-29	22	86	or	or	CCONJ
cajgh-29	22	87	nonsense	nonsense	NOUN
cajgh-29	22	88	mutations	mutation	NOUN
cajgh-29	22	89	leading	lead	VERB
cajgh-29	22	90	to	to	ADP
cajgh-29	22	91	truncated	truncated	ADJ
cajgh-29	22	92	and	and	CCONJ
cajgh-29	22	93	therefore	therefore	ADV
cajgh-29	22	94	,	,	PUNCT
cajgh-29	22	95	inactive	inactive	ADJ
cajgh-29	22	96	brca1/2	brca1/2	ADJ
cajgh-29	22	97	proteins	protein	NOUN
cajgh-29	22	98	.	.	PUNCT
cajgh-29	23	1	these	these	DET
cajgh-29	23	2	mutations	mutation	NOUN
cajgh-29	23	3	have	have	VERB
cajgh-29	23	4	a	a	DET
cajgh-29	23	5	pathogenetic	pathogenetic	ADJ
cajgh-29	23	6	role	role	NOUN
cajgh-29	23	7	and	and	CCONJ
cajgh-29	23	8	are	be	AUX
cajgh-29	23	9	characterized	characterize	VERB
cajgh-29	23	10	by	by	ADP
cajgh-29	23	11	a	a	DET
cajgh-29	23	12	high	high	ADJ
cajgh-29	23	13	penetrance	penetrance	NOUN
cajgh-29	23	14	.	.	PUNCT
cajgh-29	24	1	furthermore	furthermore	ADV
cajgh-29	24	2	,	,	PUNCT
cajgh-29	24	3	they	they	PRON
cajgh-29	24	4	are	be	AUX
cajgh-29	24	5	thought	think	VERB
cajgh-29	24	6	to	to	PART
cajgh-29	24	7	increase	increase	VERB
cajgh-29	24	8	the	the	DET
cajgh-29	24	9	lifetime	lifetime	NOUN
cajgh-29	24	10	risk	risk	NOUN
cajgh-29	24	11	of	of	ADP
cajgh-29	24	12	developing	develop	VERB
cajgh-29	24	13	breast	breast	NOUN
cajgh-29	24	14	cancer	cancer	NOUN
cajgh-29	24	15	50	50	NUM
cajgh-29	24	16	%	%	NOUN
cajgh-29	24	17	by	by	ADP
cajgh-29	24	18	age	age	NOUN
cajgh-29	24	19	50	50	NUM
cajgh-29	24	20	and	and	CCONJ
cajgh-29	24	21	85	85	NUM
cajgh-29	24	22	%	%	NOUN
cajgh-29	24	23	by	by	ADP
cajgh-29	24	24	age	age	NOUN
cajgh-29	24	25	70.27	70.27	NUM
cajgh-29	24	26	-	-	SYM
cajgh-29	24	27	29	29	NUM
cajgh-29	24	28	hundreds	hundred	NOUN
cajgh-29	24	29	of	of	ADP
cajgh-29	24	30	alterations	alteration	NOUN
cajgh-29	24	31	have	have	AUX
cajgh-29	24	32	been	be	AUX
cajgh-29	24	33	reported	report	VERB
cajgh-29	24	34	for	for	ADP
cajgh-29	24	35	brca1/2	brca1/2	ADJ
cajgh-29	24	36	genes	gene	NOUN
cajgh-29	24	37	,	,	PUNCT
cajgh-29	24	38	but	but	CCONJ
cajgh-29	24	39	not	not	PART
cajgh-29	24	40	all	all	PRON
cajgh-29	24	41	are	be	AUX
cajgh-29	24	42	able	able	ADJ
cajgh-29	24	43	to	to	PART
cajgh-29	24	44	confer	confer	VERB
cajgh-29	24	45	a	a	DET
cajgh-29	24	46	higher	high	ADJ
cajgh-29	24	47	risk	risk	NOUN
cajgh-29	24	48	of	of	ADP
cajgh-29	24	49	developing	develop	VERB
cajgh-29	24	50	breast	breast	NOUN
cajgh-29	24	51	cancer	cancer	NOUN
cajgh-29	24	52	with	with	ADP
cajgh-29	24	53	age27,28	age27,28	PROPN
cajgh-29	24	54	and	and	CCONJ
cajgh-29	24	55	,	,	PUNCT
cajgh-29	24	56	indeed	indeed	ADV
cajgh-29	24	57	,	,	PUNCT
cajgh-29	24	58	the	the	DET
cajgh-29	24	59	pathogenetic	pathogenetic	ADJ
cajgh-29	24	60	effect	effect	NOUN
cajgh-29	24	61	of	of	ADP
cajgh-29	24	62	a	a	DET
cajgh-29	24	63	significant	significant	ADJ
cajgh-29	24	64	number	number	NOUN
cajgh-29	24	65	of	of	ADP
cajgh-29	24	66	single	single	ADJ
cajgh-29	24	67	amino	amino	NOUN
cajgh-29	24	68	acid	acid	NOUN
cajgh-29	24	69	changes	change	NOUN
cajgh-29	24	70	is	be	AUX
cajgh-29	24	71	still	still	ADV
cajgh-29	24	72	unknown	unknown	ADJ
cajgh-29	24	73	.	.	PUNCT
cajgh-29	25	1	this	this	PRON
cajgh-29	25	2	is	be	AUX
cajgh-29	25	3	particularly	particularly	ADV
cajgh-29	25	4	true	true	ADJ
cajgh-29	25	5	for	for	ADP
cajgh-29	25	6	polymorphisms	polymorphism	NOUN
cajgh-29	25	7	,	,	PUNCT
cajgh-29	25	8	naturally	naturally	ADV
cajgh-29	25	9	occurring	occur	VERB
cajgh-29	25	10	gene	gene	NOUN
cajgh-29	25	11	sequence	sequence	NOUN
cajgh-29	25	12	variations	variation	NOUN
cajgh-29	25	13	,	,	PUNCT
cajgh-29	25	14	often	often	ADV
cajgh-29	25	15	affecting	affect	VERB
cajgh-29	25	16	only	only	ADV
cajgh-29	25	17	a	a	DET
cajgh-29	25	18	single	single	ADJ
cajgh-29	25	19	nucleotide	nucleotide	NOUN
cajgh-29	25	20	,	,	PUNCT
cajgh-29	25	21	that	that	PRON
cajgh-29	25	22	have	have	AUX
cajgh-29	25	23	recently	recently	ADV
cajgh-29	25	24	been	be	AUX
cajgh-29	25	25	associated	associate	VERB
cajgh-29	25	26	with	with	ADP
cajgh-29	25	27	altered	altered	ADJ
cajgh-29	25	28	cancer	cancer	NOUN
cajgh-29	25	29	risk.30	risk.30	PROPN
cajgh-29	25	30	-	-	PUNCT
cajgh-29	25	31	32	32	NUM
cajgh-29	25	32	there	there	PRON
cajgh-29	25	33	are	be	VERB
cajgh-29	25	34	also	also	ADV
cajgh-29	25	35	a	a	DET
cajgh-29	25	36	certain	certain	ADJ
cajgh-29	25	37	number	number	NOUN
cajgh-29	25	38	of	of	ADP
cajgh-29	25	39	single	single	ADJ
cajgh-29	25	40	amino	amino	NOUN
cajgh-29	25	41	acid	acid	NOUN
cajgh-29	25	42	changes	change	NOUN
cajgh-29	25	43	that	that	PRON
cajgh-29	25	44	have	have	AUX
cajgh-29	25	45	been	be	AUX
cajgh-29	25	46	identified	identify	VERB
cajgh-29	25	47	and	and	CCONJ
cajgh-29	25	48	classified	classify	VERB
cajgh-29	25	49	as	as	ADP
cajgh-29	25	50	non	non	ADJ
cajgh-29	25	51	-	-	ADJ
cajgh-29	25	52	characterized	characterized	ADJ
cajgh-29	25	53	variants	variant	NOUN
cajgh-29	25	54	.	.	PUNCT
cajgh-29	26	1	it	it	PRON
cajgh-29	26	2	is	be	AUX
cajgh-29	26	3	not	not	PART
cajgh-29	26	4	known	know	VERB
cajgh-29	26	5	whether	whether	SCONJ
cajgh-29	26	6	these	these	DET
cajgh-29	26	7	variants	variant	NOUN
cajgh-29	26	8	may	may	AUX
cajgh-29	26	9	affect	affect	VERB
cajgh-29	26	10	brca1	brca1	PROPN
cajgh-29	26	11	function	function	NOUN
cajgh-29	26	12	and	and	CCONJ
cajgh-29	26	13	thus	thus	ADV
cajgh-29	26	14	bring	bring	VERB
cajgh-29	26	15	about	about	ADP
cajgh-29	26	16	an	an	DET
cajgh-29	26	17	increased	increase	VERB
cajgh-29	26	18	risk	risk	NOUN
cajgh-29	26	19	for	for	ADP
cajgh-29	26	20	breast	breast	NOUN
cajgh-29	26	21	and/or	and/or	CCONJ
cajgh-29	26	22	ovarian	ovarian	ADJ
cajgh-29	26	23	cancer	cancer	NOUN
cajgh-29	26	24	.	.	PUNCT
cajgh-29	27	1	disease	disease	NOUN
cajgh-29	27	2	-	-	PUNCT
cajgh-29	27	3	associated	associate	VERB
cajgh-29	27	4	mutations	mutation	NOUN
cajgh-29	27	5	are	be	AUX
cajgh-29	27	6	distributed	distribute	VERB
cajgh-29	27	7	over	over	ADP
cajgh-29	27	8	the	the	DET
cajgh-29	27	9	entire	entire	ADJ
cajgh-29	27	10	coding	code	VERB
cajgh-29	27	11	regions	region	NOUN
cajgh-29	27	12	of	of	ADP
cajgh-29	27	13	these	these	DET
cajgh-29	27	14	genes	gene	NOUN
cajgh-29	27	15	,	,	PUNCT
cajgh-29	27	16	and	and	CCONJ
cajgh-29	27	17	these	these	PRON
cajgh-29	27	18	demonstrate	demonstrate	VERB
cajgh-29	27	19	considerable	considerable	ADJ
cajgh-29	27	20	ethnogeographic	ethnogeographic	ADJ
cajgh-29	27	21	variation.33	variation.33	NOUN
cajgh-29	27	22	for	for	ADP
cajgh-29	27	23	example	example	NOUN
cajgh-29	27	24	,	,	PUNCT
cajgh-29	27	25	in	in	ADP
cajgh-29	27	26	the	the	DET
cajgh-29	27	27	ashkenazi	ashkenazi	ADJ
cajgh-29	27	28	jewish34,35	jewish34,35	PROPN
cajgh-29	27	29	or	or	CCONJ
cajgh-29	27	30	in	in	ADP
cajgh-29	27	31	the	the	DET
cajgh-29	27	32	icelanders36	icelanders36	NOUN
cajgh-29	27	33	breast	breast	NOUN
cajgh-29	27	34	cancer	cancer	NOUN
cajgh-29	27	35	predisposition	predisposition	NOUN
cajgh-29	27	36	has	have	AUX
cajgh-29	27	37	been	be	AUX
cajgh-29	27	38	demonstrated	demonstrate	VERB
cajgh-29	27	39	to	to	PART
cajgh-29	27	40	be	be	AUX
cajgh-29	27	41	due	due	ADJ
cajgh-29	27	42	to	to	ADP
cajgh-29	27	43	recurrent	recurrent	ADJ
cajgh-29	27	44	mutations	mutation	NOUN
cajgh-29	27	45	(	(	PUNCT
cajgh-29	27	46	founder	founder	NOUN
cajgh-29	27	47	mutations	mutation	NOUN
cajgh-29	27	48	)	)	PUNCT
cajgh-29	27	49	originating	originate	VERB
cajgh-29	27	50	from	from	ADP
cajgh-29	27	51	a	a	DET
cajgh-29	27	52	single	single	ADJ
cajgh-29	27	53	ancestor	ancestor	NOUN
cajgh-29	27	54	.	.	PUNCT
cajgh-29	28	1	molecular	molecular	ADJ
cajgh-29	28	2	analysis	analysis	NOUN
cajgh-29	28	3	of	of	ADP
cajgh-29	28	4	brca1/2	brca1/2	NOUN
cajgh-29	28	5	in	in	ADP
cajgh-29	28	6	different	different	ADJ
cajgh-29	28	7	populations	population	NOUN
cajgh-29	28	8	has	have	AUX
cajgh-29	28	9	demonstrated	demonstrate	VERB
cajgh-29	28	10	a	a	DET
cajgh-29	28	11	very	very	ADV
cajgh-29	28	12	large	large	ADJ
cajgh-29	28	13	mutational	mutational	ADJ
cajgh-29	28	14	spectrum	spectrum	NOUN
cajgh-29	28	15	and	and	CCONJ
cajgh-29	28	16	variable	variable	ADJ
cajgh-29	28	17	mutation	mutation	NOUN
cajgh-29	28	18	prevalence	prevalence	NOUN
cajgh-29	28	19	related	relate	VERB
cajgh-29	28	20	to	to	ADP
cajgh-29	28	21	the	the	DET
cajgh-29	28	22	different	different	ADJ
cajgh-29	28	23	techniques	technique	NOUN
cajgh-29	28	24	employed	employ	VERB
cajgh-29	28	25	,	,	PUNCT
cajgh-29	28	26	selection	selection	NOUN
cajgh-29	28	27	criteria	criterion	NOUN
cajgh-29	28	28	,	,	PUNCT
cajgh-29	28	29	and	and	CCONJ
cajgh-29	28	30	ethnic	ethnic	ADJ
cajgh-29	28	31	origin	origin	NOUN
cajgh-29	28	32	of	of	ADP
cajgh-29	28	33	the	the	DET
cajgh-29	28	34	patients	patient	NOUN
cajgh-29	28	35	.	.	PUNCT
cajgh-29	29	1	in	in	ADP
cajgh-29	29	2	families	family	NOUN
cajgh-29	29	3	with	with	ADP
cajgh-29	29	4	no	no	DET
cajgh-29	29	5	prior	prior	ADJ
cajgh-29	29	6	history	history	NOUN
cajgh-29	29	7	of	of	ADP
cajgh-29	29	8	breast	breast	NOUN
cajgh-29	29	9	cancer	cancer	NOUN
cajgh-29	29	10	,	,	PUNCT
cajgh-29	29	11	frequency	frequency	NOUN
cajgh-29	29	12	of	of	ADP
cajgh-29	29	13	brca	brca	PROPN
cajgh-29	29	14	mutation	mutation	NOUN
cajgh-29	29	15	was	be	AUX
cajgh-29	29	16	found	find	VERB
cajgh-29	29	17	significantly	significantly	ADV
cajgh-29	29	18	low	low	ADJ
cajgh-29	29	19	from	from	ADP
cajgh-29	29	20	0.02	0.02	NUM
cajgh-29	29	21	%	%	NOUN
cajgh-29	29	22	to	to	ADP
cajgh-29	29	23	10%.33	10%.33	NUM
cajgh-29	29	24	in	in	ADP
cajgh-29	29	25	asia	asia	PROPN
cajgh-29	29	26	,	,	PUNCT
cajgh-29	29	27	the	the	DET
cajgh-29	29	28	prevalence	prevalence	NOUN
cajgh-29	29	29	of	of	ADP
cajgh-29	29	30	brca1/2	brca1/2	ADJ
cajgh-29	29	31	mutations	mutation	NOUN
cajgh-29	29	32	among	among	ADP
cajgh-29	29	33	unselected	unselected	ADJ
cajgh-29	29	34	breast	breast	NOUN
cajgh-29	29	35	cancer	cancer	NOUN
cajgh-29	29	36	cases	case	NOUN
cajgh-29	29	37	was	be	AUX
cajgh-29	29	38	reported	report	VERB
cajgh-29	29	39	at	at	ADP
cajgh-29	29	40	5.1	5.1	NUM
cajgh-29	29	41	%	%	NOUN
cajgh-29	29	42	in	in	ADP
cajgh-29	29	43	philippines,37	philippines,37	NOUN
cajgh-29	29	44	and	and	CCONJ
cajgh-29	29	45	2.5%–3.1	2.5%–3.1	NUM
cajgh-29	29	46	%	%	NOUN
cajgh-29	29	47	in	in	ADP
cajgh-29	29	48	korea.38,39	korea.38,39	ADJ
cajgh-29	29	49	the	the	DET
cajgh-29	29	50	frequency	frequency	NOUN
cajgh-29	29	51	of	of	ADP
cajgh-29	29	52	brca1	brca1	PROPN
cajgh-29	29	53	mutations	mutation	NOUN
cajgh-29	29	54	in	in	ADP
cajgh-29	29	55	chinese	chinese	ADJ
cajgh-29	29	56	women	woman	NOUN
cajgh-29	29	57	with	with	ADP
cajgh-29	29	58	breast	breast	NOUN
cajgh-29	29	59	cancer	cancer	NOUN
cajgh-29	29	60	without	without	ADP
cajgh-29	29	61	family	family	NOUN
cajgh-29	29	62	history	history	NOUN
cajgh-29	29	63	was	be	AUX
cajgh-29	29	64	5.4%.40	5.4%.40	NUM
cajgh-29	29	65	on	on	ADP
cajgh-29	29	66	the	the	DET
cajgh-29	29	67	other	other	ADJ
cajgh-29	29	68	hand	hand	NOUN
cajgh-29	29	69	,	,	PUNCT
cajgh-29	29	70	2	2	NUM
cajgh-29	29	71	%	%	NOUN
cajgh-29	29	72	of	of	ADP
cajgh-29	29	73	breast	breast	NOUN
cajgh-29	29	74	cancer	cancer	NOUN
cajgh-29	29	75	cases	case	NOUN
cajgh-29	29	76	in	in	ADP
cajgh-29	29	77	the	the	DET
cajgh-29	29	78	largest	large	ADJ
cajgh-29	29	79	breast	breast	NOUN
cajgh-29	29	80	cancer	cancer	NOUN
cajgh-29	29	81	population	population	NOUN
cajgh-29	29	82	-	-	PUNCT
cajgh-29	29	83	based	base	VERB
cajgh-29	29	84	study	study	NOUN
cajgh-29	29	85	in	in	ADP
cajgh-29	29	86	a	a	DET
cajgh-29	29	87	uk	uk	PROPN
cajgh-29	29	88	population	population	NOUN
cajgh-29	29	89	showed	show	VERB
cajgh-29	29	90	association	association	NOUN
cajgh-29	29	91	with	with	ADP
cajgh-29	29	92	brca	brca	PROPN
cajgh-29	29	93	genes	gene	NOUN
cajgh-29	29	94	with	with	ADP
cajgh-29	29	95	0.7	0.7	NUM
cajgh-29	29	96	%	%	NOUN
cajgh-29	29	97	attribution	attribution	NOUN
cajgh-29	29	98	of	of	ADP
cajgh-29	29	99	brca1	brca1	PROPN
cajgh-29	29	100	(	(	PUNCT
cajgh-29	29	101	anglian	anglian	ADJ
cajgh-29	29	102	breast	breast	NOUN
cajgh-29	29	103	cancer	cancer	NOUN
cajgh-29	29	104	study	study	NOUN
cajgh-29	29	105	group	group	NOUN
cajgh-29	29	106	,	,	PUNCT
cajgh-29	29	107	2000).41	2000).41	PROPN
cajgh-29	29	108	several	several	ADJ
cajgh-29	29	109	hospital	hospital	NOUN
cajgh-29	29	110	-	-	PUNCT
cajgh-29	29	111	based	base	VERB
cajgh-29	29	112	series	series	NOUN
cajgh-29	29	113	of	of	ADP
cajgh-29	29	114	unselected	unselected	ADJ
cajgh-29	29	115	breast	breast	NOUN
cajgh-29	29	116	cancers	cancer	NOUN
cajgh-29	29	117	implicate	implicate	VERB
cajgh-29	29	118	brca1	brca1	PROPN
cajgh-29	29	119	and	and	CCONJ
cajgh-29	29	120	brca2	brca2	PROPN
cajgh-29	29	121	in	in	ADP
cajgh-29	29	122	2–5	2–5	NOUN
cajgh-29	29	123	%	%	NOUN
cajgh-29	29	124	and	and	CCONJ
cajgh-29	29	125	0–2	0–2	NUM
cajgh-29	29	126	%	%	NOUN
cajgh-29	29	127	of	of	ADP
cajgh-29	29	128	all	all	DET
cajgh-29	29	129	cases	case	NOUN
cajgh-29	29	130	,	,	PUNCT
cajgh-29	29	131	respectively.41	respectively.41	ADP
cajgh-29	29	132	this	this	DET
cajgh-29	29	133	variation	variation	NOUN
cajgh-29	29	134	may	may	AUX
cajgh-29	29	135	be	be	AUX
cajgh-29	29	136	attributed	attribute	VERB
cajgh-29	29	137	to	to	ADP
cajgh-29	29	138	differences	difference	NOUN
cajgh-29	29	139	on	on	ADP
cajgh-29	29	140	the	the	DET
cajgh-29	29	141	genome	genome	NOUN
cajgh-29	29	142	level	level	NOUN
cajgh-29	29	143	among	among	ADP
cajgh-29	29	144	various	various	ADJ
cajgh-29	29	145	ethnic	ethnic	ADJ
cajgh-29	29	146	and	and	CCONJ
cajgh-29	29	147	population	population	NOUN
cajgh-29	29	148	heterogeneity	heterogeneity	NOUN
cajgh-29	29	149	.	.	PUNCT
cajgh-29	30	1	the	the	DET
cajgh-29	30	2	reason	reason	NOUN
cajgh-29	30	3	of	of	ADP
cajgh-29	30	4	marginally	marginally	ADV
cajgh-29	30	5	low	low	ADJ
cajgh-29	30	6	penetrance	penetrance	NOUN
cajgh-29	30	7	of	of	ADP
cajgh-29	30	8	brca1/2	brca1/2	NOUN
cajgh-29	30	9	germline	germline	NOUN
cajgh-29	30	10	mutations	mutation	NOUN
cajgh-29	30	11	may	may	AUX
cajgh-29	30	12	be	be	AUX
cajgh-29	30	13	attributed	attribute	VERB
cajgh-29	30	14	to	to	ADP
cajgh-29	30	15	the	the	DET
cajgh-29	30	16	polygenic	polygenic	ADJ
cajgh-29	30	17	involvement	involvement	NOUN
cajgh-29	30	18	and	and	CCONJ
cajgh-29	30	19	heterogeneity	heterogeneity	NOUN
cajgh-29	30	20	of	of	ADP
cajgh-29	30	21	samples	sample	NOUN
cajgh-29	30	22	origin	origin	NOUN
cajgh-29	30	23	too	too	ADV
cajgh-29	30	24	.	.	PUNCT
cajgh-29	31	1	as	as	ADP
cajgh-29	31	2	in	in	ADP
cajgh-29	31	3	asia	asia	PROPN
cajgh-29	31	4	,	,	PUNCT
cajgh-29	31	5	the	the	DET
cajgh-29	31	6	overall	overall	ADJ
cajgh-29	31	7	prevalence	prevalence	NOUN
cajgh-29	31	8	of	of	ADP
cajgh-29	31	9	germline	germline	NOUN
cajgh-29	31	10	mutation	mutation	NOUN
cajgh-29	31	11	varies	vary	VERB
cajgh-29	31	12	from	from	ADP
cajgh-29	31	13	0.8	0.8	NUM
cajgh-29	31	14	%	%	NOUN
cajgh-29	31	15	in	in	ADP
cajgh-29	31	16	japanese42	japanese42	NOUN
cajgh-29	31	17	to	to	ADP
cajgh-29	31	18	8.0	8.0	NUM
cajgh-29	31	19	%	%	NOUN
cajgh-29	31	20	in	in	ADP
cajgh-29	31	21	singapore	singapore	NOUN
cajgh-29	31	22	region,43	region,43	NOUN
cajgh-29	31	23	indicating	indicate	VERB
cajgh-29	31	24	involvement	involvement	NOUN
cajgh-29	31	25	of	of	ADP
cajgh-29	31	26	other	other	ADJ
cajgh-29	31	27	genes	gene	NOUN
cajgh-29	31	28	and	and	CCONJ
cajgh-29	31	29	population	population	NOUN
cajgh-29	31	30	response	response	NOUN
cajgh-29	31	31	with	with	ADP
cajgh-29	31	32	respect	respect	NOUN
cajgh-29	31	33	to	to	ADP
cajgh-29	31	34	various	various	ADJ
cajgh-29	31	35	types	type	NOUN
cajgh-29	31	36	and	and	CCONJ
cajgh-29	31	37	origin	origin	NOUN
cajgh-29	31	38	of	of	ADP
cajgh-29	31	39	cancers	cancer	NOUN
cajgh-29	31	40	.	.	PUNCT
cajgh-29	32	1	moreover	moreover	ADV
cajgh-29	32	2	,	,	PUNCT
cajgh-29	32	3	inter	inter	ADJ
cajgh-29	32	4	-	-	ADJ
cajgh-29	32	5	individual	individual	ADJ
cajgh-29	32	6	variation	variation	NOUN
cajgh-29	32	7	does	do	AUX
cajgh-29	32	8	exist	exist	VERB
cajgh-29	32	9	among	among	ADP
cajgh-29	32	10	the	the	DET
cajgh-29	32	11	ethnic	ethnic	ADJ
cajgh-29	32	12	groups	group	NOUN
cajgh-29	32	13	in	in	ADP
cajgh-29	32	14	association	association	NOUN
cajgh-29	32	15	with	with	ADP
cajgh-29	32	16	various	various	ADJ
cajgh-29	32	17	risk	risk	NOUN
cajgh-29	32	18	factors	factor	NOUN
cajgh-29	32	19	as	as	SCONJ
cajgh-29	32	20	reported	report	VERB
cajgh-29	32	21	by	by	ADP
cajgh-29	32	22	peto	peto	PROPN
cajgh-29	32	23	et	et	NOUN
cajgh-29	32	24	al.44	al.44	NOUN
cajgh-29	32	25	showing	show	VERB
cajgh-29	32	26	mutation	mutation	NOUN
cajgh-29	32	27	prevalence	prevalence	NOUN
cajgh-29	32	28	as	as	ADP
cajgh-29	32	29	3.5	3.5	NUM
cajgh-29	32	30	%	%	NOUN
cajgh-29	32	31	before	before	ADP
cajgh-29	32	32	age	age	NOUN
cajgh-29	32	33	35	35	NUM
cajgh-29	32	34	declining	decline	VERB
cajgh-29	32	35	to	to	ADP
cajgh-29	32	36	0.49	0.49	NUM
cajgh-29	32	37	%	%	NOUN
cajgh-29	32	38	in	in	ADP
cajgh-29	32	39	≥	≥	NOUN
cajgh-29	32	40	50	50	NUM
cajgh-29	32	41	years	year	NOUN
cajgh-29	32	42	.	.	PUNCT
cajgh-29	33	1	studies	study	NOUN
cajgh-29	33	2	on	on	ADP
cajgh-29	33	3	brca	brca	PROPN
cajgh-29	33	4	gene	gene	NOUN
cajgh-29	33	5	mutations	mutation	NOUN
cajgh-29	33	6	have	have	AUX
cajgh-29	33	7	been	be	AUX
cajgh-29	33	8	mainly	mainly	ADV
cajgh-29	33	9	performed	perform	VERB
cajgh-29	33	10	in	in	ADP
cajgh-29	33	11	western	western	ADJ
cajgh-29	33	12	populations	population	NOUN
cajgh-29	33	13	and	and	CCONJ
cajgh-29	33	14	the	the	DET
cajgh-29	33	15	majority	majority	NOUN
cajgh-29	33	16	of	of	ADP
cajgh-29	33	17	these	these	PRON
cajgh-29	33	18	have	have	AUX
cajgh-29	33	19	involved	involve	VERB
cajgh-29	33	20	hereditary	hereditary	ADJ
cajgh-29	33	21	breast	breast	NOUN
cajgh-29	33	22	and	and	CCONJ
cajgh-29	33	23	ovarian	ovarian	ADJ
cajgh-29	33	24	cancer	cancer	NOUN
cajgh-29	33	25	families	family	NOUN
cajgh-29	33	26	.	.	PUNCT
cajgh-29	34	1	thus	thus	ADV
cajgh-29	34	2	,	,	PUNCT
cajgh-29	34	3	studies	study	NOUN
cajgh-29	34	4	focusing	focus	VERB
cajgh-29	34	5	on	on	ADP
cajgh-29	34	6	sporadic	sporadic	ADJ
cajgh-29	34	7	breast	breast	NOUN
cajgh-29	34	8	cancer	cancer	NOUN
cajgh-29	34	9	and	and	CCONJ
cajgh-29	34	10	data	datum	NOUN
cajgh-29	34	11	collection	collection	NOUN
cajgh-29	34	12	in	in	ADP
cajgh-29	34	13	asians	asians	PROPN
cajgh-29	34	14	,	,	PUNCT
cajgh-29	34	15	especially	especially	ADV
cajgh-29	34	16	in	in	ADP
cajgh-29	34	17	the	the	DET
cajgh-29	34	18	kazakh	kazakh	ADJ
cajgh-29	34	19	population	population	NOUN
cajgh-29	34	20	,	,	PUNCT
cajgh-29	34	21	remain	remain	VERB
cajgh-29	34	22	relatively	relatively	ADV
cajgh-29	34	23	sparse	sparse	ADJ
cajgh-29	34	24	.	.	PUNCT
cajgh-29	35	1	to	to	ADP
cajgh-29	35	2	our	our	PRON
cajgh-29	35	3	knowledge	knowledge	NOUN
cajgh-29	35	4	,	,	PUNCT
cajgh-29	35	5	this	this	PRON
cajgh-29	35	6	is	be	AUX
cajgh-29	35	7	the	the	DET
cajgh-29	35	8	first	first	ADJ
cajgh-29	35	9	study	study	NOUN
cajgh-29	35	10	to	to	PART
cajgh-29	35	11	evaluate	evaluate	VERB
cajgh-29	35	12	the	the	DET
cajgh-29	35	13	frequency	frequency	NOUN
cajgh-29	35	14	and	and	CCONJ
cajgh-29	35	15	type	type	NOUN
cajgh-29	35	16	of	of	ADP
cajgh-29	35	17	sequence	sequence	NOUN
cajgh-29	35	18	alterations	alteration	NOUN
cajgh-29	35	19	of	of	ADP
cajgh-29	35	20	brca1/2	brca1/2	ADJ
cajgh-29	35	21	genes	gene	NOUN
cajgh-29	35	22	in	in	ADP
cajgh-29	35	23	kazakhstan	kazakhstan	PROPN
cajgh-29	35	24	breast	breast	NOUN
cajgh-29	35	25	cancer	cancer	NOUN
cajgh-29	35	26	patients	patient	NOUN
cajgh-29	35	27	.	.	PUNCT
cajgh-29	36	1	in	in	ADP
cajgh-29	36	2	order	order	NOUN
cajgh-29	36	3	to	to	PART
cajgh-29	36	4	evaluate	evaluate	VERB
cajgh-29	36	5	the	the	DET
cajgh-29	36	6	role	role	NOUN
cajgh-29	36	7	of	of	ADP
cajgh-29	36	8	brca1	brca1	PROPN
cajgh-29	36	9	and	and	CCONJ
cajgh-29	36	10	brca2	brca2	PROPN
cajgh-29	36	11	germline	germline	VERB
cajgh-29	36	12	mutations	mutation	NOUN
cajgh-29	36	13	in	in	ADP
cajgh-29	36	14	the	the	DET
cajgh-29	36	15	kazakhstan	kazakhstan	PROPN
cajgh-29	36	16	population	population	NOUN
cajgh-29	36	17	,	,	PUNCT
cajgh-29	36	18	156	156	NUM
cajgh-29	36	19	sporadic	sporadic	ADJ
cajgh-29	36	20	breast	breast	NOUN
cajgh-29	36	21	cancer	cancer	NOUN
cajgh-29	36	22	patients	patient	NOUN
cajgh-29	36	23	were	be	AUX
cajgh-29	36	24	analyzed	analyze	VERB
cajgh-29	36	25	for	for	ADP
cajgh-29	36	26	mutations	mutation	NOUN
cajgh-29	36	27	throughout	throughout	ADP
cajgh-29	36	28	the	the	DET
cajgh-29	36	29	entire	entire	ADJ
cajgh-29	36	30	coding	code	VERB
cajgh-29	36	31	regions	region	NOUN
cajgh-29	36	32	of	of	ADP
cajgh-29	36	33	the	the	DET
cajgh-29	36	34	brca1	brca1	NOUN
cajgh-29	36	35	and	and	CCONJ
cajgh-29	36	36	brca2	brca2	NOUN
cajgh-29	36	37	genes	gene	NOUN
cajgh-29	36	38	by	by	ADP
cajgh-29	36	39	using	use	VERB
cajgh-29	36	40	direct	direct	ADJ
cajgh-29	36	41	sequencing	sequencing	NOUN
cajgh-29	36	42	.	.	PUNCT
cajgh-29	37	1	materials	material	NOUN
cajgh-29	37	2	and	and	CCONJ
cajgh-29	37	3	methods	method	NOUN
cajgh-29	37	4	patients	patient	NOUN
cajgh-29	37	5	prior	prior	ADV
cajgh-29	37	6	to	to	ADP
cajgh-29	37	7	this	this	DET
cajgh-29	37	8	study	study	NOUN
cajgh-29	37	9	,	,	PUNCT
cajgh-29	37	10	ethical	ethical	ADJ
cajgh-29	37	11	approval	approval	NOUN
cajgh-29	37	12	was	be	AUX
cajgh-29	37	13	obtained	obtain	VERB
cajgh-29	37	14	from	from	ADP
cajgh-29	37	15	the	the	DET
cajgh-29	37	16	ethical	ethical	ADJ
cajgh-29	37	17	committees	committee	NOUN
cajgh-29	37	18	of	of	ADP
cajgh-29	37	19	semey	semey	PROPN
cajgh-29	37	20	state	state	PROPN
cajgh-29	37	21	medical	medical	PROPN
cajgh-29	37	22	university	university	PROPN
cajgh-29	37	23	and	and	CCONJ
cajgh-29	37	24	in	in	ADP
cajgh-29	37	25	national	national	ADJ
cajgh-29	37	26	center	center	NOUN
cajgh-29	37	27	for	for	ADP
cajgh-29	37	28	biotechnology	biotechnology	NOUN
cajgh-29	37	29	.	.	PUNCT
cajgh-29	38	1	a	a	DET
cajgh-29	38	2	total	total	NOUN
cajgh-29	38	3	of	of	ADP
cajgh-29	38	4	156	156	NUM
cajgh-29	38	5	kazakhstan	kazakhstan	ADJ
cajgh-29	38	6	women	woman	NOUN
cajgh-29	38	7	with	with	ADP
cajgh-29	38	8	pathologically	pathologically	ADV
cajgh-29	38	9	confirmed	confirm	VERB
cajgh-29	38	10	breast	breast	NOUN
cajgh-29	38	11	cancer	cancer	NOUN
cajgh-29	38	12	;	;	PUNCT
cajgh-29	38	13	83	83	NUM
cajgh-29	38	14	women	woman	NOUN
cajgh-29	38	15	operated	operate	VERB
cajgh-29	38	16	in	in	ADP
cajgh-29	38	17	oncological	oncological	ADJ
cajgh-29	38	18	center	center	NOUN
cajgh-29	38	19	in	in	ADP
cajgh-29	38	20	semey	semey	PROPN
cajgh-29	38	21	,	,	PUNCT
cajgh-29	38	22	semey	semey	PROPN
cajgh-29	38	23	,	,	PUNCT
cajgh-29	38	24	kazakhstan	kazakhstan	PROPN
cajgh-29	38	25	from	from	ADP
cajgh-29	38	26	1984	1984	NUM
cajgh-29	38	27	-	-	SYM
cajgh-29	38	28	2005	2005	NUM
cajgh-29	38	29	year	year	NOUN
cajgh-29	38	30	and	and	CCONJ
cajgh-29	38	31	73	73	NUM
cajgh-29	38	32	women	woman	NOUN
cajgh-29	38	33	operated	operate	VERB
cajgh-29	38	34	in	in	ADP
cajgh-29	38	35	astana	astana	PROPN
cajgh-29	38	36	oncological	oncological	ADJ
cajgh-29	38	37	center	center	NOUN
cajgh-29	38	38	,	,	PUNCT
cajgh-29	38	39	astana	astana	PROPN
cajgh-29	38	40	,	,	PUNCT
cajgh-29	38	41	kazakhstan	kazakhstan	PROPN
cajgh-29	38	42	from	from	ADP
cajgh-29	38	43	2008	2008	NUM
cajgh-29	38	44	-	-	SYM
cajgh-29	38	45	2011	2011	NUM
cajgh-29	38	46	;	;	PUNCT
cajgh-29	38	47	year	year	NOUN
cajgh-29	38	48	were	be	AUX
cajgh-29	38	49	enrolled	enrol	VERB
cajgh-29	38	50	in	in	ADP
cajgh-29	38	51	this	this	DET
cajgh-29	38	52	study	study	NOUN
cajgh-29	38	53	(	(	PUNCT
cajgh-29	38	54	breast	breast	NOUN
cajgh-29	38	55	cancer	cancer	NOUN
cajgh-29	38	56	group	group	NOUN
cajgh-29	38	57	)	)	PUNCT
cajgh-29	38	58	.	.	PUNCT
cajgh-29	39	1	family	family	NOUN
cajgh-29	39	2	histories	history	NOUN
cajgh-29	39	3	were	be	AUX
cajgh-29	39	4	obtained	obtain	VERB
cajgh-29	39	5	through	through	ADP
cajgh-29	39	6	individual	individual	ADJ
cajgh-29	39	7	interviews	interview	NOUN
cajgh-29	39	8	and	and	CCONJ
cajgh-29	39	9	only	only	ADJ
cajgh-29	39	10	cases	case	NOUN
cajgh-29	39	11	without	without	ADP
cajgh-29	39	12	family	family	NOUN
cajgh-29	39	13	history	history	NOUN
cajgh-29	39	14	of	of	ADP
cajgh-29	39	15	affected	affect	VERB
cajgh-29	39	16	firstor	firstor	NOUN
cajgh-29	39	17	second	second	ADJ
cajgh-29	39	18	-	-	PUNCT
cajgh-29	39	19	degree	degree	NOUN
cajgh-29	39	20	relatives	relative	NOUN
cajgh-29	39	21	with	with	ADP
cajgh-29	39	22	breast	breast	NOUN
cajgh-29	39	23	and/or	and/or	CCONJ
cajgh-29	39	24	ovarian	ovarian	ADJ
cajgh-29	39	25	cancer	cancer	NOUN
cajgh-29	39	26	were	be	AUX
cajgh-29	39	27	included	include	VERB
cajgh-29	39	28	in	in	ADP
cajgh-29	39	29	this	this	DET
cajgh-29	39	30	study	study	NOUN
cajgh-29	39	31	.	.	PUNCT
cajgh-29	40	1	clinical	clinical	ADJ
cajgh-29	40	2	and	and	CCONJ
cajgh-29	40	3	pathological	pathological	ADJ
cajgh-29	40	4	characteristics	characteristic	NOUN
cajgh-29	40	5	such	such	ADJ
cajgh-29	40	6	as	as	ADP
cajgh-29	40	7	:	:	PUNCT
cajgh-29	40	8	age	age	NOUN
cajgh-29	40	9	at	at	ADP
cajgh-29	40	10	diagnosis	diagnosis	NOUN
cajgh-29	40	11	(	(	PUNCT
cajgh-29	40	12	operation	operation	NOUN
cajgh-29	40	13	)	)	PUNCT
cajgh-29	40	14	,	,	PUNCT
cajgh-29	40	15	histological	histological	ADJ
cajgh-29	40	16	subtype	subtype	NOUN
cajgh-29	40	17	(	(	PUNCT
cajgh-29	40	18	who	who	PRON
cajgh-29	40	19	histological	histological	ADJ
cajgh-29	40	20	classification)45	classification)45	PROPN
cajgh-29	40	21	histological	histological	ADJ
cajgh-29	40	22	grade	grade	NOUN
cajgh-29	40	23	,	,	PUNCT
cajgh-29	40	24	t	t	NOUN
cajgh-29	40	25	stage	stage	NOUN
cajgh-29	40	26	(	(	PUNCT
cajgh-29	40	27	tnm	tnm	PROPN
cajgh-29	40	28	clinical	clinical	ADJ
cajgh-29	40	29	classification	classification	NOUN
cajgh-29	40	30	,	,	PUNCT
cajgh-29	40	31	and	and	CCONJ
cajgh-29	40	32	lymph	lymph	NOUN
cajgh-29	40	33	node	node	PROPN
cajgh-29	40	34	involvement	involvement	NOUN
cajgh-29	40	35	were	be	AUX
cajgh-29	40	36	obtained	obtain	VERB
cajgh-29	40	37	from	from	ADP
cajgh-29	40	38	medical	medical	ADJ
cajgh-29	40	39	records	record	NOUN
cajgh-29	40	40	.	.	PUNCT
cajgh-29	41	1	control	control	NOUN
cajgh-29	41	2	subjects	subject	NOUN
cajgh-29	41	3	,	,	PUNCT
cajgh-29	41	4	matched	match	VERB
cajgh-29	41	5	to	to	ADP
cajgh-29	41	6	cases	case	NOUN
cajgh-29	41	7	based	base	VERB
cajgh-29	41	8	on	on	ADP
cajgh-29	41	9	age	age	NOUN
cajgh-29	41	10	and	and	CCONJ
cajgh-29	41	11	ethnicity	ethnicity	NOUN
cajgh-29	41	12	were	be	AUX
cajgh-29	41	13	randomly	randomly	ADV
cajgh-29	41	14	selected	select	VERB
cajgh-29	41	15	from	from	ADP
cajgh-29	41	16	the	the	DET
cajgh-29	41	17	community	community	NOUN
cajgh-29	41	18	in	in	ADP
cajgh-29	41	19	semey	semey	PROPN
cajgh-29	41	20	and	and	CCONJ
cajgh-29	41	21	astana	astana	PROPN
cajgh-29	41	22	(	(	PUNCT
cajgh-29	41	23	n=112	n=112	PROPN
cajgh-29	41	24	)	)	PUNCT
cajgh-29	41	25	.	.	PUNCT
cajgh-29	42	1	none	none	NOUN
cajgh-29	42	2	of	of	ADP
cajgh-29	42	3	the	the	DET
cajgh-29	42	4	controls	control	NOUN
cajgh-29	42	5	had	have	VERB
cajgh-29	42	6	a	a	DET
cajgh-29	42	7	personal	personal	ADJ
cajgh-29	42	8	history	history	NOUN
cajgh-29	42	9	of	of	ADP
cajgh-29	42	10	malignancy	malignancy	NOUN
cajgh-29	42	11	at	at	ADP
cajgh-29	42	12	the	the	DET
cajgh-29	42	13	time	time	NOUN
cajgh-29	42	14	of	of	ADP
cajgh-29	42	15	ascertainment	ascertainment	NOUN
cajgh-29	42	16	.	.	PUNCT
cajgh-29	43	1	before	before	ADP
cajgh-29	43	2	the	the	DET
cajgh-29	43	3	study	study	NOUN
cajgh-29	43	4	,	,	PUNCT
cajgh-29	43	5	written	write	VERB
cajgh-29	43	6	informed	informed	ADJ
cajgh-29	43	7	consent	consent	NOUN
cajgh-29	43	8	was	be	AUX
cajgh-29	43	9	obtained	obtain	VERB
cajgh-29	43	10	from	from	ADP
cajgh-29	43	11	all	all	DET
cajgh-29	43	12	participants	participant	NOUN
cajgh-29	43	13	.	.	PUNCT
cajgh-29	44	1	both	both	DET
cajgh-29	44	2	cases	case	NOUN
cajgh-29	44	3	and	and	CCONJ
cajgh-29	44	4	controls	control	NOUN
cajgh-29	44	5	were	be	AUX
cajgh-29	44	6	divided	divide	VERB
cajgh-29	44	7	in	in	ADP
cajgh-29	44	8	to	to	ADP
cajgh-29	44	9	two	two	NUM
cajgh-29	44	10	groups	group	NOUN
cajgh-29	44	11	by	by	ADP
cajgh-29	44	12	race	race	NOUN
cajgh-29	44	13	(	(	PUNCT
cajgh-29	44	14	by	by	ADP
cajgh-29	44	15	first	first	ADJ
cajgh-29	44	16	name	name	NOUN
cajgh-29	44	17	of	of	ADP
cajgh-29	44	18	study	study	NOUN
cajgh-29	44	19	participants	participant	NOUN
cajgh-29	44	20	and	and	CCONJ
cajgh-29	44	21	their	their	PRON
cajgh-29	44	22	parents	parent	NOUN
cajgh-29	44	23	):	):	PUNCT
cajgh-29	44	24	caucasian	caucasian	PROPN
cajgh-29	44	25	(	(	PUNCT
cajgh-29	44	26	n=88	n=88	ADJ
cajgh-29	44	27	and	and	CCONJ
cajgh-29	44	28	40	40	NUM
cajgh-29	44	29	cases	case	NOUN
cajgh-29	44	30	and	and	CCONJ
cajgh-29	44	31	controls	control	NOUN
cajgh-29	44	32	,	,	PUNCT
cajgh-29	44	33	respectively	respectively	ADV
cajgh-29	44	34	)	)	PUNCT
cajgh-29	44	35	and	and	CCONJ
cajgh-29	44	36	asian	asian	ADJ
cajgh-29	44	37	(	(	PUNCT
cajgh-29	44	38	n=68	n=68	ADV
cajgh-29	44	39	and	and	CCONJ
cajgh-29	44	40	72	72	NUM
cajgh-29	44	41	cases	case	NOUN
cajgh-29	44	42	and	and	CCONJ
cajgh-29	44	43	controls	control	NOUN
cajgh-29	44	44	,	,	PUNCT
cajgh-29	44	45	respectively	respectively	ADV
cajgh-29	44	46	)	)	PUNCT
cajgh-29	44	47	.	.	PUNCT
cajgh-29	45	1	blood	blood	NOUN
cajgh-29	45	2	sample	sample	NOUN
cajgh-29	45	3	collection	collection	NOUN
cajgh-29	45	4	peripheral	peripheral	ADJ
cajgh-29	45	5	blood	blood	NOUN
cajgh-29	45	6	samples	sample	NOUN
cajgh-29	45	7	(	(	PUNCT
cajgh-29	45	8	ca.10	ca.10	NOUN
cajgh-29	45	9	ml	ml	VERB
cajgh-29	45	10	)	)	PUNCT
cajgh-29	45	11	were	be	AUX
cajgh-29	45	12	collected	collect	VERB
cajgh-29	45	13	into	into	ADP
cajgh-29	45	14	vacutainers	vacutainer	NOUN
cajgh-29	45	15	with	with	ADP
cajgh-29	45	16	k2edta	k2edta	PROPN
cajgh-29	45	17	.	.	PUNCT
cajgh-29	46	1	dna	dna	PROPN
cajgh-29	46	2	extraction	extraction	NOUN
cajgh-29	46	3	genomic	genomic	NOUN
cajgh-29	46	4	dna	dna	PROPN
cajgh-29	46	5	was	be	AUX
cajgh-29	46	6	extracted	extract	VERB
cajgh-29	46	7	from	from	ADP
cajgh-29	46	8	whole	whole	ADJ
cajgh-29	46	9	blood	blood	NOUN
cajgh-29	46	10	samples	sample	NOUN
cajgh-29	46	11	from	from	ADP
cajgh-29	46	12	cases	case	NOUN
cajgh-29	46	13	with	with	ADP
cajgh-29	46	14	breast	breast	NOUN
cajgh-29	46	15	cancer	cancer	NOUN
cajgh-29	46	16	as	as	ADV
cajgh-29	46	17	well	well	ADV
cajgh-29	46	18	as	as	ADP
cajgh-29	46	19	controls	control	NOUN
cajgh-29	46	20	using	use	VERB
cajgh-29	46	21	a	a	DET
cajgh-29	46	22	master	master	NOUN
cajgh-29	46	23	pure	pure	ADJ
cajgh-29	46	24	dna	dna	PROPN
cajgh-29	46	25	purification	purification	NOUN
cajgh-29	46	26	kit	kit	NOUN
cajgh-29	46	27	(	(	PUNCT
cajgh-29	46	28	epicentre	epicentre	NOUN
cajgh-29	46	29	biotechnologies	biotechnology	NOUN
cajgh-29	46	30	,	,	PUNCT
cajgh-29	46	31	usa	usa	PROPN
cajgh-29	46	32	)	)	PUNCT
cajgh-29	46	33	and	and	CCONJ
cajgh-29	46	34	dna	dna	PROPN
cajgh-29	46	35	extraction	extraction	NOUN
cajgh-29	46	36	kit	kit	NOUN
cajgh-29	46	37	(	(	PUNCT
cajgh-29	46	38	promega	promega	PROPN
cajgh-29	46	39	,	,	PUNCT
cajgh-29	46	40	usa	usa	PROPN
cajgh-29	46	41	)	)	PUNCT
cajgh-29	46	42	in	in	ADP
cajgh-29	46	43	accordance	accordance	NOUN
cajgh-29	46	44	with	with	ADP
cajgh-29	46	45	the	the	DET
cajgh-29	46	46	manufacturer	manufacturer	NOUN
cajgh-29	46	47	’s	’s	PART
cajgh-29	46	48	protocols	protocol	NOUN
cajgh-29	46	49	.	.	PUNCT
cajgh-29	47	1	polymerase	polymerase	NOUN
cajgh-29	47	2	chain	chain	NOUN
cajgh-29	47	3	reaction	reaction	NOUN
cajgh-29	47	4	:	:	PUNCT
cajgh-29	47	5	for	for	ADP
cajgh-29	47	6	pcr	pcr	ADJ
cajgh-29	47	7	amplification	amplification	NOUN
cajgh-29	47	8	of	of	ADP
cajgh-29	47	9	the	the	DET
cajgh-29	47	10	22	22	NUM
cajgh-29	47	11	coding	code	VERB
cajgh-29	47	12	regions	region	NOUN
cajgh-29	47	13	of	of	ADP
cajgh-29	47	14	brca1	brca1	PROPN
cajgh-29	47	15	and	and	CCONJ
cajgh-29	47	16	the	the	DET
cajgh-29	47	17	26	26	NUM
cajgh-29	47	18	coding	code	VERB
cajgh-29	47	19	regions	region	NOUN
cajgh-29	47	20	of	of	ADP
cajgh-29	47	21	brca2	brca2	NOUN
cajgh-29	47	22	,	,	PUNCT
cajgh-29	47	23	primers	primer	NOUN
cajgh-29	47	24	using	use	VERB
cajgh-29	47	25	primer	primer	NOUN
cajgh-29	47	26	3	3	NUM
cajgh-29	47	27	v.	v.	ADP
cajgh-29	47	28	0.4.0	0.4.0	PROPN
cajgh-29	47	29	program	program	NOUN
cajgh-29	47	30	were	be	AUX
cajgh-29	47	31	designed	design	VERB
cajgh-29	47	32	(	(	PUNCT
cajgh-29	47	33	available	available	ADJ
cajgh-29	47	34	from	from	ADP
cajgh-29	47	35	authors	author	NOUN
cajgh-29	47	36	on	on	ADP
cajgh-29	47	37	request	request	NOUN
cajgh-29	47	38	)	)	PUNCT
cajgh-29	47	39	.	.	PUNCT
cajgh-29	48	1	since	since	SCONJ
cajgh-29	48	2	exon	exon	NOUN
cajgh-29	48	3	11	11	NUM
cajgh-29	48	4	of	of	ADP
cajgh-29	48	5	brca1	brca1	PROPN
cajgh-29	48	6	varies	varie	NOUN
cajgh-29	48	7	by	by	ADP
cajgh-29	48	8	3426	3426	NUM
cajgh-29	48	9	base	base	NOUN
cajgh-29	48	10	pairs	pair	NOUN
cajgh-29	48	11	,	,	PUNCT
cajgh-29	48	12	we	we	PRON
cajgh-29	48	13	amplified	amplify	VERB
cajgh-29	48	14	10	10	NUM
cajgh-29	48	15	overlapping	overlap	VERB
cajgh-29	48	16	regions	region	NOUN
cajgh-29	48	17	of	of	ADP
cajgh-29	48	18	this	this	DET
cajgh-29	48	19	exon	exon	NOUN
cajgh-29	48	20	;	;	PUNCT
cajgh-29	48	21	for	for	ADP
cajgh-29	48	22	exon	exon	NOUN
cajgh-29	48	23	10	10	NUM
cajgh-29	48	24	of	of	ADP
cajgh-29	48	25	brca2	brca2	PROPN
cajgh-29	48	26	,	,	PUNCT
cajgh-29	48	27	we	we	PRON
cajgh-29	48	28	designed	design	VERB
cajgh-29	48	29	2	2	NUM
cajgh-29	48	30	pairs	pair	NOUN
cajgh-29	48	31	of	of	ADP
cajgh-29	48	32	primers	primer	NOUN
cajgh-29	48	33	and	and	CCONJ
cajgh-29	48	34	for	for	ADP
cajgh-29	48	35	exon	exon	NOUN
cajgh-29	48	36	11	11	NUM
cajgh-29	48	37	of	of	ADP
cajgh-29	48	38	brca2	brca2	NOUN
cajgh-29	48	39	3	3	NUM
cajgh-29	48	40	pairs	pair	NOUN
cajgh-29	48	41	of	of	ADP
cajgh-29	48	42	primers	primer	NOUN
cajgh-29	48	43	.	.	PUNCT
cajgh-29	49	1	amplification	amplification	NOUN
cajgh-29	49	2	of	of	ADP
cajgh-29	49	3	dna	dna	PROPN
cajgh-29	49	4	fragments	fragment	NOUN
cajgh-29	49	5	was	be	AUX
cajgh-29	49	6	performed	perform	VERB
cajgh-29	49	7	in	in	ADP
cajgh-29	49	8	tetrad	tetrad	ADJ
cajgh-29	49	9	biorad	biorad	PROPN
cajgh-29	49	10	thermal	thermal	PROPN
cajgh-29	49	11	cycler	cycler	PROPN
cajgh-29	49	12	(	(	PUNCT
cajgh-29	49	13	bio	bio	PROPN
cajgh-29	49	14	rad	rad	PROPN
cajgh-29	49	15	,	,	PUNCT
cajgh-29	49	16	usa	usa	PROPN
cajgh-29	49	17	)	)	PUNCT
cajgh-29	49	18	in	in	ADP
cajgh-29	49	19	25μl	25μl	NOUN
cajgh-29	49	20	of	of	ADP
cajgh-29	49	21	solution	solution	NOUN
cajgh-29	49	22	containing	contain	VERB
cajgh-29	49	23	150	150	NUM
cajgh-29	49	24	mm	mm	NUM
cajgh-29	49	25	tris	tris	PROPN
cajgh-29	49	26	–	–	PUNCT
cajgh-29	49	27	hcl	hcl	PROPN
cajgh-29	49	28	(	(	PUNCT
cajgh-29	49	29	ph	ph	PROPN
cajgh-29	49	30	8.0	8.0	NUM
cajgh-29	49	31	)	)	PUNCT
cajgh-29	49	32	,	,	PUNCT
cajgh-29	49	33	500	500	NUM
cajgh-29	49	34	mm	mm	NOUN
cajgh-29	49	35	kcl	kcl	PROPN
cajgh-29	49	36	,	,	PUNCT
cajgh-29	49	37	25	25	NUM
cajgh-29	49	38	mm	mm	NOUN
cajgh-29	49	39	mgcl2	mgcl2	PROPN
cajgh-29	49	40	,	,	PUNCT
cajgh-29	49	41	10	10	NUM
cajgh-29	49	42	mm	mm	NOUN
cajgh-29	49	43	each	each	DET
cajgh-29	49	44	dntp	dntp	NOUN
cajgh-29	49	45	,	,	PUNCT
cajgh-29	49	46	10	10	NUM
cajgh-29	49	47	pmol	pmol	NOUN
cajgh-29	49	48	of	of	ADP
cajgh-29	49	49	primers	primer	NOUN
cajgh-29	49	50	,	,	PUNCT
cajgh-29	49	51	25–125	25–125	PROPN
cajgh-29	49	52	ng	ng	PROPN
cajgh-29	49	53	of	of	ADP
cajgh-29	49	54	genomic	genomic	PROPN
cajgh-29	49	55	dna	dna	PROPN
cajgh-29	49	56	,	,	PUNCT
cajgh-29	49	57	and	and	CCONJ
cajgh-29	49	58	2	2	NUM
cajgh-29	49	59	units	unit	NOUN
cajgh-29	49	60	of	of	ADP
cajgh-29	49	61	amplitaq	amplitaq	PROPN
cajgh-29	49	62	gold	gold	PROPN
cajgh-29	49	63	dna	dna	PROPN
cajgh-29	49	64	polymerase	polymerase	NOUN
cajgh-29	49	65	.	.	PUNCT
cajgh-29	50	1	the	the	DET
cajgh-29	50	2	pcr	pcr	NOUN
cajgh-29	50	3	was	be	AUX
cajgh-29	50	4	performed	perform	VERB
cajgh-29	50	5	according	accord	VERB
cajgh-29	50	6	to	to	ADP
cajgh-29	50	7	the	the	DET
cajgh-29	50	8	following	following	ADJ
cajgh-29	50	9	conditions	condition	NOUN
cajgh-29	50	10	:	:	PUNCT
cajgh-29	50	11	initial	initial	ADJ
cajgh-29	50	12	denaturation	denaturation	NOUN
cajgh-29	50	13	at	at	ADP
cajgh-29	50	14	95	95	NUM
cajgh-29	50	15	°	°	ADP
cajgh-29	50	16	c	c	NOUN
cajgh-29	50	17	for	for	ADP
cajgh-29	50	18	10	10	NUM
cajgh-29	50	19	minutes	minute	NOUN
cajgh-29	50	20	,	,	PUNCT
cajgh-29	50	21	followed	follow	VERB
cajgh-29	50	22	by	by	ADP
cajgh-29	50	23	35	35	NUM
cajgh-29	50	24	cycles	cycle	NOUN
cajgh-29	50	25	of	of	ADP
cajgh-29	50	26	95	95	NUM
cajgh-29	50	27	°	°	ADP
cajgh-29	50	28	c	c	NOUN
cajgh-29	50	29	for	for	ADP
cajgh-29	50	30	15	15	NUM
cajgh-29	50	31	seconds	second	NOUN
cajgh-29	50	32	,	,	PUNCT
cajgh-29	50	33	58	58	NUM
cajgh-29	50	34	°	°	NUM
cajgh-29	50	35	c	c	NOUN
cajgh-29	50	36	for	for	ADP
cajgh-29	50	37	30	30	NUM
cajgh-29	50	38	seconds	second	NOUN
cajgh-29	50	39	,	,	PUNCT
cajgh-29	50	40	and	and	CCONJ
cajgh-29	50	41	72	72	NUM
cajgh-29	50	42	°	°	NOUN
cajgh-29	50	43	c	c	NOUN
cajgh-29	50	44	for	for	ADP
cajgh-29	50	45	30	30	NUM
cajgh-29	50	46	seconds	second	NOUN
cajgh-29	50	47	.	.	PUNCT
cajgh-29	51	1	the	the	DET
cajgh-29	51	2	quality	quality	NOUN
cajgh-29	51	3	of	of	ADP
cajgh-29	51	4	amplification	amplification	NOUN
cajgh-29	51	5	was	be	AUX
cajgh-29	51	6	determined	determine	VERB
cajgh-29	51	7	by	by	ADP
cajgh-29	51	8	separation	separation	NOUN
cajgh-29	51	9	of	of	ADP
cajgh-29	51	10	the	the	DET
cajgh-29	51	11	pcr	pcr	ADJ
cajgh-29	51	12	products	product	NOUN
cajgh-29	51	13	on	on	ADP
cajgh-29	51	14	a	a	DET
cajgh-29	51	15	1.5	1.5	NUM
cajgh-29	51	16	%	%	NOUN
cajgh-29	51	17	agarose	agarose	X
cajgh-29	51	18	gel	gel	NOUN
cajgh-29	51	19	.	.	PUNCT
cajgh-29	52	1	the	the	DET
cajgh-29	52	2	pcr	pcr	PROPN
cajgh-29	52	3	products	product	NOUN
cajgh-29	52	4	were	be	AUX
cajgh-29	52	5	purified	purify	VERB
cajgh-29	52	6	using	use	VERB
cajgh-29	52	7	exosap	exosap	NOUN
cajgh-29	52	8	-	-	PUNCT
cajgh-29	52	9	it	it	PRON
cajgh-29	52	10	(	(	PUNCT
cajgh-29	52	11	usb	usb	PROPN
cajgh-29	52	12	,	,	PUNCT
cajgh-29	52	13	usa	usa	PROPN
cajgh-29	52	14	)	)	PUNCT
cajgh-29	52	15	and	and	CCONJ
cajgh-29	52	16	incubated	incubate	VERB
cajgh-29	52	17	at	at	ADP
cajgh-29	52	18	37	37	NUM
cajgh-29	52	19	°	°	ADP
cajgh-29	52	20	c	c	NOUN
cajgh-29	52	21	for	for	ADP
cajgh-29	52	22	40	40	NUM
cajgh-29	52	23	min	min	NOUN
cajgh-29	52	24	,	,	PUNCT
cajgh-29	52	25	80	80	NUM
cajgh-29	53	1	°	°	SYM
cajgh-29	53	2	c	c	NOUN
cajgh-29	53	3	for	for	ADP
cajgh-29	53	4	20	20	NUM
cajgh-29	53	5	min	min	NOUN
cajgh-29	53	6	,	,	PUNCT
cajgh-29	53	7	and	and	CCONJ
cajgh-29	53	8	stored	store	VERB
cajgh-29	53	9	at	at	ADP
cajgh-29	53	10	4	4	NUM
cajgh-29	53	11	°	°	NOUN
cajgh-29	53	12	c	c	NOUN
cajgh-29	53	13	.	.	PUNCT
cajgh-29	54	1	purified	purified	ADJ
cajgh-29	54	2	pcr	pcr	ADJ
cajgh-29	54	3	products	product	NOUN
cajgh-29	54	4	were	be	AUX
cajgh-29	54	5	further	far	ADV
cajgh-29	54	6	used	use	VERB
cajgh-29	54	7	in	in	ADP
cajgh-29	54	8	the	the	DET
cajgh-29	54	9	sequencing	sequence	VERB
cajgh-29	54	10	reaction	reaction	NOUN
cajgh-29	54	11	process	process	NOUN
cajgh-29	54	12	.	.	PUNCT
cajgh-29	55	1	dna	dna	PROPN
cajgh-29	55	2	sequencing	sequence	VERB
cajgh-29	55	3	all	all	DET
cajgh-29	55	4	amplified	amplified	ADJ
cajgh-29	55	5	products	product	NOUN
cajgh-29	55	6	were	be	AUX
cajgh-29	55	7	sequenced	sequence	VERB
cajgh-29	55	8	in	in	ADP
cajgh-29	55	9	forward	forward	ADV
cajgh-29	55	10	and	and	CCONJ
cajgh-29	55	11	reverse	reverse	ADJ
cajgh-29	55	12	directions	direction	NOUN
cajgh-29	55	13	using	use	VERB
cajgh-29	55	14	the	the	DET
cajgh-29	55	15	bigdye	bigdye	NOUN
cajgh-29	55	16	terminator	terminator	NOUN
cajgh-29	55	17	v3.1	v3.1	ADP
cajgh-29	55	18	cycle	cycle	NOUN
cajgh-29	55	19	sequencing	sequence	VERB
cajgh-29	55	20	kit	kit	NOUN
cajgh-29	55	21	(	(	PUNCT
cajgh-29	55	22	applied	apply	VERB
cajgh-29	55	23	biosystems	biosystem	NOUN
cajgh-29	55	24	,	,	PUNCT
cajgh-29	55	25	usa	usa	PROPN
cajgh-29	55	26	)	)	PUNCT
cajgh-29	55	27	on	on	ADP
cajgh-29	55	28	an	an	DET
cajgh-29	55	29	abi	abi	PROPN
cajgh-29	55	30	3130xl	3130xl	PROPN
cajgh-29	55	31	dna	dna	PROPN
cajgh-29	55	32	analyzer	analyzer	NOUN
cajgh-29	55	33	(	(	PUNCT
cajgh-29	55	34	applied	apply	VERB
cajgh-29	55	35	biosystems	biosystem	NOUN
cajgh-29	55	36	,	,	PUNCT
cajgh-29	55	37	foster	foster	ADJ
cajgh-29	55	38	city	city	NOUN
cajgh-29	55	39	,	,	PUNCT
cajgh-29	55	40	ca	ca	PROPN
cajgh-29	55	41	,	,	PUNCT
cajgh-29	55	42	usa	usa	PROPN
cajgh-29	55	43	)	)	PUNCT
cajgh-29	55	44	.	.	PUNCT
cajgh-29	56	1	the	the	DET
cajgh-29	56	2	pcr	pcr	PROPN
cajgh-29	56	3	products	product	NOUN
cajgh-29	56	4	were	be	AUX
cajgh-29	56	5	sequenced	sequence	VERB
cajgh-29	56	6	using	use	VERB
cajgh-29	56	7	the	the	DET
cajgh-29	56	8	same	same	ADJ
cajgh-29	56	9	primers	primer	NOUN
cajgh-29	56	10	as	as	ADP
cajgh-29	56	11	the	the	DET
cajgh-29	56	12	ones	one	NOUN
cajgh-29	56	13	used	use	VERB
cajgh-29	56	14	for	for	ADP
cajgh-29	56	15	pcr	pcr	ADJ
cajgh-29	56	16	amplification	amplification	NOUN
cajgh-29	56	17	.	.	PUNCT
cajgh-29	57	1	sequence	sequence	NOUN
cajgh-29	57	2	pcr	pcr	NOUN
cajgh-29	57	3	products	product	NOUN
cajgh-29	57	4	were	be	AUX
cajgh-29	57	5	cleaned	clean	VERB
cajgh-29	57	6	using	use	VERB
cajgh-29	57	7	sefadex	sefadex	NOUN
cajgh-29	57	8	50	50	NUM
cajgh-29	57	9	and	and	CCONJ
cajgh-29	57	10	multiscreen	multiscreen	NOUN
cajgh-29	57	11	filtration	filtration	NOUN
cajgh-29	57	12	colons	colon	NOUN
cajgh-29	57	13	(	(	PUNCT
cajgh-29	57	14	millipore	millipore	NOUN
cajgh-29	57	15	corporation	corporation	PROPN
cajgh-29	57	16	,	,	PUNCT
cajgh-29	57	17	usa	usa	PROPN
cajgh-29	57	18	)	)	PUNCT
cajgh-29	57	19	.	.	PUNCT
cajgh-29	58	1	a	a	DET
cajgh-29	58	2	chromatographic	chromatographic	ADJ
cajgh-29	58	3	tracing	tracing	NOUN
cajgh-29	58	4	of	of	ADP
cajgh-29	58	5	each	each	DET
cajgh-29	58	6	amplicon	amplicon	NOUN
cajgh-29	58	7	was	be	AUX
cajgh-29	58	8	analyzed	analyze	VERB
cajgh-29	58	9	by	by	ADP
cajgh-29	58	10	proprietary	proprietary	ADJ
cajgh-29	58	11	sequence	sequence	NOUN
cajgh-29	58	12	analysis	analysis	NOUN
cajgh-29	58	13	software	software	NOUN
cajgh-29	58	14	(	(	PUNCT
cajgh-29	58	15	sequence	sequence	NOUN
cajgh-29	58	16	analysis	analysis	NOUN
cajgh-29	58	17	5.3.1	5.3.1	NUM
cajgh-29	58	18	,	,	PUNCT
cajgh-29	58	19	seqscape	seqscape	NOUN
cajgh-29	58	20	v.2.6	v.2.6	PROPN
cajgh-29	58	21	,	,	PUNCT
cajgh-29	58	22	finch	finch	NOUN
cajgh-29	58	23	tv	tv	PROPN
cajgh-29	58	24	v1.3.1	v1.3.1	PROPN
cajgh-29	58	25	)	)	PUNCT
cajgh-29	58	26	followed	follow	VERB
cajgh-29	58	27	by	by	ADP
cajgh-29	58	28	visual	visual	ADJ
cajgh-29	58	29	inspection	inspection	NOUN
cajgh-29	58	30	and	and	CCONJ
cajgh-29	58	31	confirmation	confirmation	NOUN
cajgh-29	58	32	.	.	PUNCT
cajgh-29	59	1	the	the	DET
cajgh-29	59	2	sequence	sequence	NOUN
cajgh-29	59	3	was	be	AUX
cajgh-29	59	4	compared	compare	VERB
cajgh-29	59	5	with	with	ADP
cajgh-29	59	6	the	the	DET
cajgh-29	59	7	breast	breast	NOUN
cajgh-29	59	8	cancer	cancer	NOUN
cajgh-29	59	9	information	information	NOUN
cajgh-29	59	10	core	core	NOUN
cajgh-29	59	11	,	,	PUNCT
cajgh-29	59	12	bicdatabase	bicdatabase	NOUN
cajgh-29	59	13	;	;	PUNCT
cajgh-29	59	14	http://research.nhgri.nih.gov/bic	http://research.nhgri.nih.gov/bic	PROPN
cajgh-29	59	15	)	)	PUNCT
cajgh-29	59	16	,	,	PUNCT
cajgh-29	59	17	human	human	ADJ
cajgh-29	59	18	genome	genome	NOUN
cajgh-29	59	19	mutation	mutation	NOUN
cajgh-29	59	20	database	database	NOUN
cajgh-29	59	21	(	(	PUNCT
cajgh-29	59	22	http://www.hgmd.cf.ac.uk/ac/index.php	http://www.hgmd.cf.ac.uk/ac/index.php	NUM
cajgh-29	59	23	)	)	PUNCT
cajgh-29	59	24	and	and	CCONJ
cajgh-29	59	25	the	the	DET
cajgh-29	59	26	national	national	ADJ
cajgh-29	59	27	center	center	NOUN
cajgh-29	59	28	for	for	ADP
cajgh-29	59	29	biotechnology	biotechnology	NOUN
cajgh-29	59	30	information	information	NOUN
cajgh-29	59	31	database	database	NOUN
cajgh-29	59	32	(	(	PUNCT
cajgh-29	59	33	http://	http://	PROPN
cajgh-29	59	34	www.ncbi.nlm.nih.gov	www.ncbi.nlm.nih.gov	ADJ
cajgh-29	59	35	)	)	PUNCT
cajgh-29	59	36	.	.	PUNCT
cajgh-29	60	1	mutation	mutation	NOUN
cajgh-29	60	2	nomenclature	nomenclature	NOUN
cajgh-29	60	3	approved	approve	VERB
cajgh-29	60	4	recommendations	recommendation	NOUN
cajgh-29	60	5	of	of	ADP
cajgh-29	60	6	nomenclature	nomenclature	NOUN
cajgh-29	60	7	for	for	ADP
cajgh-29	60	8	the	the	DET
cajgh-29	60	9	description	description	NOUN
cajgh-29	60	10	of	of	ADP
cajgh-29	60	11	sequence	sequence	NOUN
cajgh-29	60	12	variants	variant	NOUN
cajgh-29	60	13	were	be	AUX
cajgh-29	60	14	adopted	adopt	VERB
cajgh-29	60	15	(	(	PUNCT
cajgh-29	60	16	(	(	PUNCT
cajgh-29	60	17	http://www.hgvs.org/mutnomen/	http://www.hgvs.org/mutnomen/	NOUN
cajgh-29	60	18	)	)	PUNCT
cajgh-29	60	19	.	.	PUNCT
cajgh-29	61	1	numbering	number	VERB
cajgh-29	61	2	according	accord	VERB
cajgh-29	61	3	to	to	ADP
cajgh-29	61	4	genbank	genbank	PROPN
cajgh-29	61	5	accession	accession	NOUN
cajgh-29	61	6	no	no	INTJ
cajgh-29	61	7	.	.	PROPN
cajgh-29	61	8	nm_007294.1	nm_007294.1	PROPN
cajgh-29	61	9	for	for	ADP
cajgh-29	61	10	brca1	brca1	PROPN
cajgh-29	61	11	and	and	CCONJ
cajgh-29	61	12	nm_000059.1	nm_000059.1	PROPN
cajgh-29	61	13	for	for	ADP
cajgh-29	61	14	brca2	brca2	PROPN
cajgh-29	61	15	,	,	PUNCT
cajgh-29	61	16	the	the	DET
cajgh-29	61	17	a	a	NOUN
cajgh-29	61	18	of	of	ADP
cajgh-29	61	19	the	the	DET
cajgh-29	61	20	atg	atg	PROPN
cajgh-29	61	21	translation	translation	NOUN
cajgh-29	61	22	initiation	initiation	NOUN
cajgh-29	61	23	codon	codon	PROPN
cajgh-29	61	24	is	be	AUX
cajgh-29	61	25	+1	+1	PROPN
cajgh-29	61	26	,	,	PUNCT
cajgh-29	61	27	according	accord	VERB
cajgh-29	61	28	to	to	ADP
cajgh-29	61	29	approved	approve	VERB
cajgh-29	61	30	guidelines	guideline	NOUN
cajgh-29	61	31	were	be	AUX
cajgh-29	61	32	used	use	VERB
cajgh-29	61	33	.	.	PUNCT
cajgh-29	62	1	also	also	ADV
cajgh-29	62	2	,	,	PUNCT
cajgh-29	62	3	traditional	traditional	ADJ
cajgh-29	62	4	mutation	mutation	NOUN
cajgh-29	62	5	nomenclature	nomenclature	NOUN
cajgh-29	62	6	used	use	VERB
cajgh-29	62	7	in	in	ADP
cajgh-29	62	8	bic	bic	PROPN
cajgh-29	62	9	database26	database26	NOUN
cajgh-29	62	10	where	where	SCONJ
cajgh-29	62	11	nucleotide	nucleotide	ADJ
cajgh-29	62	12	numbers	number	NOUN
cajgh-29	62	13	refer	refer	VERB
cajgh-29	62	14	to	to	ADP
cajgh-29	62	15	the	the	DET
cajgh-29	62	16	wild	wild	ADJ
cajgh-29	62	17	type	type	NOUN
cajgh-29	62	18	cdna	cdna	PROPN
cajgh-29	62	19	sequence	sequence	NOUN
cajgh-29	62	20	of	of	ADP
cajgh-29	62	21	brca1	brca1	PROPN
cajgh-29	62	22	(	(	PUNCT
cajgh-29	62	23	refseq	refseq	NOUN
cajgh-29	62	24	accession	accession	NOUN
cajgh-29	62	25	number	number	NOUN
cajgh-29	62	26	u14680	u14680	PROPN
cajgh-29	62	27	)	)	PUNCT
cajgh-29	62	28	with	with	ADP
cajgh-29	62	29	numbering	numbering	NOUN
cajgh-29	62	30	starting	start	VERB
cajgh-29	62	31	at	at	ADP
cajgh-29	62	32	the	the	DET
cajgh-29	62	33	a	a	NOUN
cajgh-29	62	34	of	of	ADP
cajgh-29	62	35	the	the	DET
cajgh-29	62	36	first	first	ADJ
cajgh-29	62	37	atg	atg	NOUN
cajgh-29	62	38	at	at	ADP
cajgh-29	62	39	the	the	DET
cajgh-29	62	40	position	position	NOUN
cajgh-29	62	41	120	120	NUM
cajgh-29	62	42	and	and	CCONJ
cajgh-29	62	43	to	to	ADP
cajgh-29	62	44	the	the	DET
cajgh-29	62	45	wild	wild	ADJ
cajgh-29	62	46	type	type	NOUN
cajgh-29	62	47	cdna	cdna	PROPN
cajgh-29	62	48	sequence	sequence	NOUN
cajgh-29	62	49	of	of	ADP
cajgh-29	62	50	brca2	brca2	PROPN
cajgh-29	62	51	(	(	PUNCT
cajgh-29	62	52	refseq	refseq	NOUN
cajgh-29	62	53	accession	accession	NOUN
cajgh-29	62	54	number	number	NOUN
cajgh-29	62	55	u43746	u43746	PROPN
cajgh-29	62	56	)	)	PUNCT
cajgh-29	62	57	with	with	ADP
cajgh-29	62	58	numbering	numbering	NOUN
cajgh-29	62	59	starting	start	VERB
cajgh-29	62	60	at	at	ADP
cajgh-29	62	61	the	the	DET
cajgh-29	62	62	a	a	NOUN
cajgh-29	62	63	of	of	ADP
cajgh-29	62	64	the	the	DET
cajgh-29	62	65	first	first	ADJ
cajgh-29	62	66	atg	atg	NOUN
cajgh-29	62	67	at	at	ADP
cajgh-29	62	68	the	the	DET
cajgh-29	62	69	position	position	NOUN
cajgh-29	62	70	229	229	NUM
cajgh-29	62	71	were	be	AUX
cajgh-29	62	72	used	use	VERB
cajgh-29	62	73	.	.	PUNCT
cajgh-29	63	1	we	we	PRON
cajgh-29	63	2	used	use	VERB
cajgh-29	63	3	the	the	DET
cajgh-29	63	4	term	term	NOUN
cajgh-29	63	5	"	"	PUNCT
cajgh-29	63	6	sequence	sequence	NOUN
cajgh-29	63	7	variation	variation	NOUN
cajgh-29	63	8	"	"	PUNCT
cajgh-29	63	9	and	and	CCONJ
cajgh-29	63	10	“	"	PUNCT
cajgh-29	63	11	sequence	sequence	NOUN
cajgh-29	63	12	alteration	alteration	NOUN
cajgh-29	63	13	”	"	PUNCT
cajgh-29	63	14	to	to	PART
cajgh-29	63	15	prevent	prevent	VERB
cajgh-29	63	16	confusion	confusion	NOUN
cajgh-29	63	17	with	with	ADP
cajgh-29	63	18	the	the	DET
cajgh-29	63	19	terms	term	NOUN
cajgh-29	63	20	"	"	PUNCT
cajgh-29	63	21	mutation	mutation	NOUN
cajgh-29	63	22	"	"	PUNCT
cajgh-29	63	23	and	and	CCONJ
cajgh-29	63	24	"	"	PUNCT
cajgh-29	63	25	polymorphism	polymorphism	NOUN
cajgh-29	63	26	"	"	PUNCT
cajgh-29	63	27	,	,	PUNCT
cajgh-29	63	28	mutation	mutation	NOUN
cajgh-29	63	29	meaning	mean	VERB
cajgh-29	63	30	"	"	PUNCT
cajgh-29	63	31	change	change	NOUN
cajgh-29	63	32	"	"	PUNCT
cajgh-29	63	33	or	or	CCONJ
cajgh-29	63	34	"	"	PUNCT
cajgh-29	63	35	disease	disease	NOUN
cajgh-29	63	36	-	-	PUNCT
cajgh-29	63	37	causing	cause	VERB
cajgh-29	63	38	change	change	NOUN
cajgh-29	63	39	"	"	PUNCT
cajgh-29	63	40	and	and	CCONJ
cajgh-29	63	41	polymorphism	polymorphism	NOUN
cajgh-29	63	42	meaning	mean	VERB
cajgh-29	63	43	"	"	PUNCT
cajgh-29	63	44	non	non	ADJ
cajgh-29	63	45	disease	disease	NOUN
cajgh-29	63	46	-	-	PUNCT
cajgh-29	63	47	causing	cause	VERB
cajgh-29	63	48	change	change	NOUN
cajgh-29	63	49	"	"	PUNCT
cajgh-29	63	50	or	or	CCONJ
cajgh-29	63	51	"	"	PUNCT
cajgh-29	63	52	change	change	NOUN
cajgh-29	63	53	found	find	VERB
cajgh-29	63	54	at	at	ADP
cajgh-29	63	55	a	a	DET
cajgh-29	63	56	frequency	frequency	NOUN
cajgh-29	63	57	of	of	ADP
cajgh-29	63	58	1	1	NUM
cajgh-29	63	59	%	%	NOUN
cajgh-29	63	60	or	or	CCONJ
cajgh-29	63	61	higher	high	ADJ
cajgh-29	63	62	in	in	ADP
cajgh-29	63	63	the	the	DET
cajgh-29	63	64	population	population	NOUN
cajgh-29	63	65	"	"	PUNCT
cajgh-29	63	66	.	.	PUNCT
cajgh-29	64	1	single	single	ADJ
cajgh-29	64	2	-	-	PUNCT
cajgh-29	64	3	nucleotide	nucleotide	NOUN
cajgh-29	64	4	polymorphisms	polymorphism	NOUN
cajgh-29	64	5	may	may	AUX
cajgh-29	64	6	fall	fall	VERB
cajgh-29	64	7	within	within	ADP
cajgh-29	64	8	coding	code	VERB
cajgh-29	64	9	sequences	sequence	NOUN
cajgh-29	64	10	of	of	ADP
cajgh-29	64	11	genes	gene	NOUN
cajgh-29	64	12	,	,	PUNCT
cajgh-29	64	13	non	non	ADJ
cajgh-29	64	14	-	-	ADJ
cajgh-29	64	15	coding	coding	ADJ
cajgh-29	64	16	regions	region	NOUN
cajgh-29	64	17	of	of	ADP
cajgh-29	64	18	genes	gene	NOUN
cajgh-29	64	19	,	,	PUNCT
cajgh-29	64	20	or	or	CCONJ
cajgh-29	64	21	in	in	ADP
cajgh-29	64	22	the	the	DET
cajgh-29	64	23	intergenic	intergenic	ADJ
cajgh-29	64	24	regions	region	NOUN
cajgh-29	64	25	(	(	PUNCT
cajgh-29	64	26	regions	region	NOUN
cajgh-29	64	27	between	between	ADP
cajgh-29	64	28	genes	gene	NOUN
cajgh-29	64	29	)	)	PUNCT
cajgh-29	64	30	.	.	PUNCT
cajgh-29	65	1	snps	snps	PROPN
cajgh-29	65	2	within	within	ADP
cajgh-29	65	3	a	a	DET
cajgh-29	65	4	coding	code	VERB
cajgh-29	65	5	sequence	sequence	NOUN
cajgh-29	65	6	do	do	AUX
cajgh-29	65	7	not	not	PART
cajgh-29	65	8	necessarily	necessarily	ADV
cajgh-29	65	9	change	change	VERB
cajgh-29	65	10	the	the	DET
cajgh-29	65	11	amino	amino	NOUN
cajgh-29	65	12	acid	acid	NOUN
cajgh-29	65	13	sequence	sequence	NOUN
cajgh-29	65	14	of	of	ADP
cajgh-29	65	15	the	the	DET
cajgh-29	65	16	protein	protein	NOUN
cajgh-29	65	17	that	that	PRON
cajgh-29	65	18	is	be	AUX
cajgh-29	65	19	produced	produce	VERB
cajgh-29	65	20	,	,	PUNCT
cajgh-29	65	21	due	due	ADP
cajgh-29	65	22	to	to	ADP
cajgh-29	65	23	degeneracy	degeneracy	NOUN
cajgh-29	65	24	of	of	ADP
cajgh-29	65	25	the	the	DET
cajgh-29	65	26	genetic	genetic	ADJ
cajgh-29	65	27	code	code	NOUN
cajgh-29	65	28	.	.	PUNCT
cajgh-29	66	1	a	a	DET
cajgh-29	66	2	snp	snp	NOUN
cajgh-29	66	3	in	in	ADP
cajgh-29	66	4	which	which	PRON
cajgh-29	66	5	both	both	DET
cajgh-29	66	6	alleles	allele	NOUN
cajgh-29	66	7	produce	produce	VERB
cajgh-29	66	8	the	the	DET
cajgh-29	66	9	same	same	ADJ
cajgh-29	66	10	polypeptide	polypeptide	ADJ
cajgh-29	66	11	sequence	sequence	NOUN
cajgh-29	66	12	is	be	AUX
cajgh-29	66	13	called	call	VERB
cajgh-29	66	14	a	a	DET
cajgh-29	66	15	synonymous	synonymous	ADJ
cajgh-29	66	16	polymorphism	polymorphism	NOUN
cajgh-29	66	17	(	(	PUNCT
cajgh-29	66	18	sometimes	sometimes	ADV
cajgh-29	66	19	called	call	VERB
cajgh-29	66	20	a	a	DET
cajgh-29	66	21	silent	silent	ADJ
cajgh-29	66	22	mutation	mutation	NOUN
cajgh-29	66	23	)	)	PUNCT
cajgh-29	66	24	.	.	PUNCT
cajgh-29	67	1	if	if	SCONJ
cajgh-29	67	2	a	a	DET
cajgh-29	67	3	different	different	ADJ
cajgh-29	67	4	polypeptide	polypeptide	ADJ
cajgh-29	67	5	sequence	sequence	NOUN
cajgh-29	67	6	is	be	AUX
cajgh-29	67	7	produced	produce	VERB
cajgh-29	67	8	,	,	PUNCT
cajgh-29	67	9	the	the	DET
cajgh-29	67	10	polymorphism	polymorphism	NOUN
cajgh-29	67	11	is	be	AUX
cajgh-29	67	12	a	a	DET
cajgh-29	67	13	replacement	replacement	NOUN
cajgh-29	67	14	polymorphism	polymorphism	NOUN
cajgh-29	67	15	.	.	PUNCT
cajgh-29	68	1	a	a	DET
cajgh-29	68	2	replacement	replacement	NOUN
cajgh-29	68	3	polymorphism	polymorphism	NOUN
cajgh-29	68	4	change	change	NOUN
cajgh-29	68	5	may	may	AUX
cajgh-29	68	6	be	be	AUX
cajgh-29	68	7	either	either	DET
cajgh-29	68	8	missense	missense	NOUN
cajgh-29	68	9	,	,	PUNCT
cajgh-29	68	10	which	which	PRON
cajgh-29	68	11	results	result	VERB
cajgh-29	68	12	in	in	ADP
cajgh-29	68	13	a	a	DET
cajgh-29	68	14	different	different	ADJ
cajgh-29	68	15	amino	amino	NOUN
cajgh-29	68	16	acid	acid	NOUN
cajgh-29	68	17	,	,	PUNCT
cajgh-29	68	18	or	or	CCONJ
cajgh-29	68	19	nonsense	nonsense	NOUN
cajgh-29	68	20	,	,	PUNCT
cajgh-29	68	21	which	which	PRON
cajgh-29	68	22	results	result	VERB
cajgh-29	68	23	in	in	ADP
cajgh-29	68	24	a	a	DET
cajgh-29	68	25	premature	premature	ADJ
cajgh-29	68	26	stop	stop	NOUN
cajgh-29	68	27	codon	codon	NOUN
cajgh-29	68	28	.	.	PUNCT
cajgh-29	69	1	over	over	ADP
cajgh-29	69	2	half	half	NOUN
cajgh-29	69	3	of	of	ADP
cajgh-29	69	4	all	all	DET
cajgh-29	69	5	known	know	VERB
cajgh-29	69	6	disease	disease	NOUN
cajgh-29	69	7	mutations	mutation	NOUN
cajgh-29	69	8	come	come	VERB
cajgh-29	69	9	from	from	ADP
cajgh-29	69	10	replacement	replacement	NOUN
cajgh-29	69	11	polymorphisms.24	polymorphisms.24	NOUN
cajgh-29	69	12	a	a	DET
cajgh-29	69	13	variation	variation	NOUN
cajgh-29	69	14	in	in	ADP
cajgh-29	69	15	a	a	DET
cajgh-29	69	16	genetic	genetic	ADJ
cajgh-29	69	17	sequence	sequence	NOUN
cajgh-29	69	18	whose	whose	DET
cajgh-29	69	19	association	association	NOUN
cajgh-29	69	20	with	with	ADP
cajgh-29	69	21	disease	disease	NOUN
cajgh-29	69	22	risk	risk	NOUN
cajgh-29	69	23	is	be	AUX
cajgh-29	69	24	unknown	unknown	ADJ
cajgh-29	69	25	is	be	AUX
cajgh-29	69	26	also	also	ADV
cajgh-29	69	27	called	call	VERB
cajgh-29	69	28	a	a	DET
cajgh-29	69	29	variant	variant	NOUN
cajgh-29	69	30	of	of	ADP
cajgh-29	69	31	uncertain	uncertain	ADJ
cajgh-29	69	32	significance	significance	NOUN
cajgh-29	69	33	,	,	PUNCT
cajgh-29	69	34	unclassified	unclassified	ADJ
cajgh-29	69	35	variant	variant	NOUN
cajgh-29	69	36	,	,	PUNCT
cajgh-29	69	37	and	and	CCONJ
cajgh-29	69	38	vus	vus	X
cajgh-29	69	39	(	(	PUNCT
cajgh-29	69	40	an	an	DET
cajgh-29	69	41	alteration	alteration	NOUN
cajgh-29	69	42	in	in	ADP
cajgh-29	69	43	the	the	DET
cajgh-29	69	44	normal	normal	ADJ
cajgh-29	69	45	sequence	sequence	NOUN
cajgh-29	69	46	of	of	ADP
cajgh-29	69	47	a	a	DET
cajgh-29	69	48	gene	gene	NOUN
cajgh-29	69	49	,	,	PUNCT
cajgh-29	69	50	the	the	DET
cajgh-29	69	51	significance	significance	NOUN
cajgh-29	69	52	of	of	ADP
cajgh-29	69	53	which	which	PRON
cajgh-29	69	54	is	be	AUX
cajgh-29	69	55	unclear	unclear	ADJ
cajgh-29	69	56	until	until	ADP
cajgh-29	69	57	further	further	ADJ
cajgh-29	69	58	study	study	NOUN
cajgh-29	69	59	of	of	ADP
cajgh-29	69	60	the	the	DET
cajgh-29	69	61	genotype	genotype	NOUN
cajgh-29	69	62	and	and	CCONJ
cajgh-29	69	63	corresponding	correspond	VERB
cajgh-29	69	64	phenotype	phenotype	NOUN
cajgh-29	69	65	in	in	ADP
cajgh-29	69	66	a	a	DET
cajgh-29	69	67	sufficiently	sufficiently	ADV
cajgh-29	69	68	large	large	ADJ
cajgh-29	69	69	population	population	NOUN
cajgh-29	69	70	)	)	PUNCT
cajgh-29	69	71	.	.	PUNCT
cajgh-29	70	1	statistical	statistical	ADJ
cajgh-29	70	2	analysis	analysis	NOUN
cajgh-29	70	3	clinical	clinical	ADJ
cajgh-29	70	4	and	and	CCONJ
cajgh-29	70	5	pathological	pathological	ADJ
cajgh-29	70	6	characteristics	characteristic	NOUN
cajgh-29	70	7	and	and	CCONJ
cajgh-29	70	8	brca	brca	PROPN
cajgh-29	70	9	mutation	mutation	NOUN
cajgh-29	70	10	results	result	NOUN
cajgh-29	70	11	were	be	AUX
cajgh-29	70	12	analyzed	analyze	VERB
cajgh-29	70	13	using	use	VERB
cajgh-29	70	14	spss	spss	PROPN
cajgh-29	70	15	19.0	19.0	NUM
cajgh-29	70	16	(	(	PUNCT
cajgh-29	70	17	spss	spss	PROPN
cajgh-29	70	18	,	,	PUNCT
cajgh-29	70	19	tokyo	tokyo	PROPN
cajgh-29	70	20	,	,	PUNCT
cajgh-29	70	21	japan	japan	PROPN
cajgh-29	70	22	)	)	PUNCT
cajgh-29	70	23	.	.	PUNCT
cajgh-29	71	1	differences	difference	NOUN
cajgh-29	71	2	in	in	ADP
cajgh-29	71	3	categorical	categorical	ADJ
cajgh-29	71	4	variables	variable	NOUN
cajgh-29	71	5	between	between	ADP
cajgh-29	71	6	mutation	mutation	NOUN
cajgh-29	71	7	-	-	PUNCT
cajgh-29	71	8	positive	positive	ADJ
cajgh-29	71	9	and	and	CCONJ
cajgh-29	71	10	mutation	mutation	NOUN
cajgh-29	71	11	-	-	PUNCT
cajgh-29	71	12	negative	negative	ADJ
cajgh-29	71	13	group	group	NOUN
cajgh-29	71	14	were	be	AUX
cajgh-29	71	15	compared	compare	VERB
cajgh-29	71	16	using	use	VERB
cajgh-29	71	17	chi	chi	ADJ
cajgh-29	71	18	-	-	PUNCT
cajgh-29	71	19	square	square	NOUN
cajgh-29	71	20	analysis	analysis	NOUN
cajgh-29	71	21	,	,	PUNCT
cajgh-29	71	22	cross	cross	NOUN
cajgh-29	71	23	tables	table	NOUN
cajgh-29	71	24	or	or	CCONJ
cajgh-29	71	25	fisher	fisher	NOUN
cajgh-29	71	26	’s	’s	PART
cajgh-29	71	27	exact	exact	ADJ
cajgh-29	71	28	test	test	NOUN
cajgh-29	71	29	.	.	PUNCT
cajgh-29	72	1	a	a	DET
cajgh-29	72	2	probability	probability	NOUN
cajgh-29	72	3	value	value	NOUN
cajgh-29	72	4	of	of	ADP
cajgh-29	72	5	less	less	ADJ
cajgh-29	72	6	than	than	ADP
cajgh-29	72	7	0.05	0.05	NUM
cajgh-29	72	8	was	be	AUX
cajgh-29	72	9	considered	consider	VERB
cajgh-29	72	10	to	to	PART
cajgh-29	72	11	indicate	indicate	VERB
cajgh-29	72	12	significance	significance	NOUN
cajgh-29	72	13	.	.	PUNCT
cajgh-29	73	1	results	result	NOUN
cajgh-29	73	2	mean	mean	VERB
cajgh-29	73	3	age	age	NOUN
cajgh-29	73	4	of	of	ADP
cajgh-29	73	5	breast	breast	NOUN
cajgh-29	73	6	cancer	cancer	NOUN
cajgh-29	73	7	patients	patient	NOUN
cajgh-29	73	8	and	and	CCONJ
cajgh-29	73	9	controls	control	NOUN
cajgh-29	73	10	was	be	AUX
cajgh-29	73	11	51.2±9.5	51.2±9.5	NUM
cajgh-29	73	12	years	year	NOUN
cajgh-29	73	13	and	and	CCONJ
cajgh-29	73	14	57.8±9.1	57.8±9.1	NUM
cajgh-29	73	15	years	year	NOUN
cajgh-29	73	16	,	,	PUNCT
cajgh-29	73	17	respectively	respectively	ADV
cajgh-29	73	18	.	.	PUNCT
cajgh-29	74	1	sixty	sixty	NUM
cajgh-29	74	2	-	-	PUNCT
cajgh-29	74	3	eight	eight	NUM
cajgh-29	74	4	women	woman	NOUN
cajgh-29	74	5	with	with	ADP
cajgh-29	74	6	breast	breast	NOUN
cajgh-29	74	7	cancer	cancer	NOUN
cajgh-29	74	8	were	be	AUX
cajgh-29	74	9	asian	asian	ADJ
cajgh-29	74	10	and	and	CCONJ
cajgh-29	74	11	eighty	eighty	NUM
cajgh-29	74	12	eight	eight	NUM
cajgh-29	74	13	–	–	PUNCT
cajgh-29	74	14	caucasian	caucasian	ADJ
cajgh-29	74	15	.	.	PUNCT
cajgh-29	75	1	among	among	ADP
cajgh-29	75	2	healthy	healthy	ADJ
cajgh-29	75	3	women	woman	NOUN
cajgh-29	75	4	,	,	PUNCT
cajgh-29	75	5	72	72	NUM
cajgh-29	75	6	were	be	AUX
cajgh-29	75	7	asian	asian	ADJ
cajgh-29	75	8	and	and	CCONJ
cajgh-29	75	9	40	40	NUM
cajgh-29	75	10	caucasian	caucasian	ADJ
cajgh-29	75	11	.	.	PUNCT
cajgh-29	76	1	all	all	DET
cajgh-29	76	2	breast	breast	NOUN
cajgh-29	76	3	cancer	cancer	NOUN
cajgh-29	76	4	cases	case	NOUN
cajgh-29	76	5	were	be	AUX
cajgh-29	76	6	distributed	distribute	VERB
cajgh-29	76	7	by	by	ADP
cajgh-29	76	8	size	size	NOUN
cajgh-29	76	9	of	of	ADP
cajgh-29	76	10	primary	primary	ADJ
cajgh-29	76	11	breast	breast	NOUN
cajgh-29	76	12	carcinoma	carcinoma	NOUN
cajgh-29	76	13	(	(	PUNCT
cajgh-29	76	14	tnm	tnm	NUM
cajgh-29	76	15	clinical	clinical	ADJ
cajgh-29	76	16	classification45	classification45	NOUN
cajgh-29	76	17	):	):	PUNCT
cajgh-29	76	18	t1	t1	NOUN
cajgh-29	76	19	,	,	PUNCT
cajgh-29	76	20	t2	t2	NOUN
cajgh-29	76	21	,	,	PUNCT
cajgh-29	76	22	t3	t3	PROPN
cajgh-29	76	23	,	,	PUNCT
cajgh-29	76	24	t4	t4	PROPN
cajgh-29	76	25	–	–	PUNCT
cajgh-29	76	26	15	15	NUM
cajgh-29	76	27	,	,	PUNCT
cajgh-29	76	28	96	96	NUM
cajgh-29	76	29	,	,	PUNCT
cajgh-29	76	30	39	39	NUM
cajgh-29	76	31	,	,	PUNCT
cajgh-29	76	32	6	6	NUM
cajgh-29	76	33	cases	case	NOUN
cajgh-29	76	34	respectively	respectively	ADV
cajgh-29	76	35	,	,	PUNCT
cajgh-29	76	36	14	14	NUM
cajgh-29	76	37	cases	case	NOUN
cajgh-29	76	38	with	with	ADP
cajgh-29	76	39	n1	n1	ADJ
cajgh-29	76	40	lymph	lymph	NOUN
cajgh-29	76	41	node	node	NOUN
cajgh-29	76	42	metastasis	metastasis	NOUN
cajgh-29	76	43	,	,	PUNCT
cajgh-29	76	44	15	15	NUM
cajgh-29	76	45	women	woman	NOUN
cajgh-29	76	46	with	with	ADP
cajgh-29	76	47	n1	n1	ADJ
cajgh-29	76	48	lymph	lymph	NOUN
cajgh-29	76	49	node	node	NOUN
cajgh-29	76	50	metastasis	metastasis	NOUN
cajgh-29	76	51	,	,	PUNCT
cajgh-29	76	52	and	and	CCONJ
cajgh-29	76	53	5	5	NUM
cajgh-29	76	54	women	woman	NOUN
cajgh-29	76	55	had	have	VERB
cajgh-29	76	56	n3	n3	ADJ
cajgh-29	76	57	lymph	lymph	NOUN
cajgh-29	76	58	node	node	PROPN
cajgh-29	76	59	involvement	involvement	NOUN
cajgh-29	76	60	.	.	PUNCT
cajgh-29	77	1	a	a	DET
cajgh-29	77	2	summary	summary	NOUN
cajgh-29	77	3	of	of	ADP
cajgh-29	77	4	patient	patient	ADJ
cajgh-29	77	5	characteristics	characteristic	NOUN
cajgh-29	77	6	can	can	AUX
cajgh-29	77	7	be	be	AUX
cajgh-29	77	8	found	find	VERB
cajgh-29	77	9	in	in	ADP
cajgh-29	77	10	:	:	PUNCT
cajgh-29	77	11	table	table	NOUN
cajgh-29	77	12	1	1	NUM
cajgh-29	77	13	:	:	PUNCT
cajgh-29	77	14	characteristics	characteristic	NOUN
cajgh-29	77	15	of	of	ADP
cajgh-29	77	16	study	study	NOUN
cajgh-29	77	17	participants	participant	NOUN
cajgh-29	77	18	breast	breast	NOUN
cajgh-29	77	19	cancer	cancer	NOUN
cajgh-29	77	20	cases	case	NOUN
cajgh-29	77	21	(	(	PUNCT
cajgh-29	77	22	n=156	n=156	NOUN
cajgh-29	77	23	)	)	PUNCT
cajgh-29	77	24	controls	control	NOUN
cajgh-29	77	25	(	(	PUNCT
cajgh-29	77	26	n=112	n=112	NOUN
cajgh-29	77	27	)	)	PUNCT
cajgh-29	77	28	abs(%	abs(%	NOUN
cajgh-29	77	29	)	)	PUNCT
cajgh-29	77	30	totally	totally	ADV
cajgh-29	77	31	(	(	PUNCT
cajgh-29	77	32	n=268	n=268	NOUN
cajgh-29	77	33	)	)	PUNCT
cajgh-29	77	34	abs	ab	NOUN
cajgh-29	77	35	(	(	PUNCT
cajgh-29	77	36	%	%	INTJ
cajgh-29	77	37	)	)	PUNCT
cajgh-29	77	38	abs	ab	NOUN
cajgh-29	77	39	t1	t1	NOUN
cajgh-29	77	40	abs	ab	NOUN
cajgh-29	77	41	(	(	PUNCT
cajgh-29	77	42	%	%	INTJ
cajgh-29	77	43	)	)	PUNCT
cajgh-29	77	44	t2	t2	NOUN
cajgh-29	77	45	abs	ab	NOUN
cajgh-29	77	46	(	(	PUNCT
cajgh-29	77	47	%	%	INTJ
cajgh-29	77	48	)	)	PUNCT
cajgh-29	78	1	t3	t3	NOUN
cajgh-29	78	2	abs	ab	NOUN
cajgh-29	78	3	(	(	PUNCT
cajgh-29	78	4	%	%	INTJ
cajgh-29	78	5	)	)	PUNCT
cajgh-29	78	6	t4	t4	PROPN
cajgh-29	78	7	abs	ab	NOUN
cajgh-29	78	8	(	(	PUNCT
cajgh-29	78	9	%	%	INTJ
cajgh-29	78	10	)	)	PUNCT
cajgh-29	78	11	n1	n1	NOUN
cajgh-29	78	12	abs	ab	NOUN
cajgh-29	78	13	(	(	PUNCT
cajgh-29	78	14	%	%	INTJ
cajgh-29	78	15	)	)	PUNCT
cajgh-29	78	16	n2	n2	ADJ
cajgh-29	78	17	abs	ab	NOUN
cajgh-29	78	18	(	(	PUNCT
cajgh-29	78	19	%	%	INTJ
cajgh-29	78	20	)	)	PUNCT
cajgh-29	78	21	n3	n3	ADJ
cajgh-29	78	22	abs	ab	NOUN
cajgh-29	78	23	(	(	PUNCT
cajgh-29	78	24	%	%	NOUN
cajgh-29	78	25	)	)	PUNCT
cajgh-29	78	26	age	age	NOUN
cajgh-29	78	27	(	(	PUNCT
cajgh-29	78	28	years	year	NOUN
cajgh-29	78	29	)	)	PUNCT
cajgh-29	78	30	at	at	ADP
cajgh-29	78	31	operation	operation	NOUN
cajgh-29	78	32	(	(	PUNCT
cajgh-29	78	33	patients)/sample	patients)/sample	NOUN
cajgh-29	78	34	collection	collection	NOUN
cajgh-29	78	35	(	(	PUNCT
cajgh-29	78	36	controls),mean±sd	controls),mean±sd	PROPN
cajgh-29	78	37	51.2±9.5	51.2±9.5	NUM
cajgh-29	78	38	*	*	SYM
cajgh-29	78	39	57.8±9.1	57.8±9.1	NUM
cajgh-29	78	40	asian	asian	NOUN
cajgh-29	78	41	68	68	NUM
cajgh-29	78	42	10	10	NUM
cajgh-29	78	43	(	(	PUNCT
cajgh-29	78	44	15.1	15.1	NUM
cajgh-29	78	45	)	)	PUNCT
cajgh-29	78	46	43	43	NUM
cajgh-29	78	47	(	(	PUNCT
cajgh-29	78	48	63.6	63.6	NUM
cajgh-29	78	49	)	)	SYM
cajgh-29	78	50	14	14	NUM
cajgh-29	78	51	(	(	PUNCT
cajgh-29	78	52	21.2	21.2	NUM
cajgh-29	78	53	)	)	SYM
cajgh-29	78	54	1	1	NUM
cajgh-29	78	55	(	(	PUNCT
cajgh-29	78	56	1.5	1.5	NUM
cajgh-29	78	57	)	)	PUNCT
cajgh-29	78	58	9	9	NUM
cajgh-29	78	59	(	(	PUNCT
cajgh-29	78	60	13.2	13.2	NUM
cajgh-29	78	61	)	)	PUNCT
cajgh-29	78	62	6	6	NUM
cajgh-29	78	63	(	(	PUNCT
cajgh-29	78	64	9.0	9.0	NUM
cajgh-29	78	65	)	)	PUNCT
cajgh-29	78	66	72	72	NUM
cajgh-29	78	67	(	(	PUNCT
cajgh-29	78	68	64.3	64.3	NUM
cajgh-29	78	69	)	)	PUNCT
cajgh-29	78	70	144	144	NUM
cajgh-29	78	71	(	(	PUNCT
cajgh-29	78	72	53.8	53.8	NUM
cajgh-29	78	73	)	)	PUNCT
cajgh-29	78	74	caucasian	caucasian	NOUN
cajgh-29	78	75	88	88	NUM
cajgh-29	78	76	5	5	NUM
cajgh-29	78	77	<	<	X
cajgh-29	78	78	(	(	PUNCT
cajgh-29	78	79	6.0	6.0	NUM
cajgh-29	78	80	)	)	PUNCT
cajgh-29	78	81	53	53	NUM
cajgh-29	78	82	(	(	PUNCT
cajgh-29	78	83	60.0	60.0	NUM
cajgh-29	78	84	)	)	SYM
cajgh-29	78	85	25	25	NUM
cajgh-29	78	86	(	(	PUNCT
cajgh-29	78	87	28	28	NUM
cajgh-29	78	88	)	)	PUNCT
cajgh-29	78	89	5	5	NUM
cajgh-29	78	90	(	(	PUNCT
cajgh-29	78	91	6.0	6.0	NUM
cajgh-29	78	92	)	)	PUNCT
cajgh-29	78	93	5	5	NUM
cajgh-29	78	94	(	(	PUNCT
cajgh-29	78	95	6.0	6.0	NUM
cajgh-29	78	96	)	)	PUNCT
cajgh-29	78	97	9	9	NUM
cajgh-29	78	98	(	(	PUNCT
cajgh-29	78	99	10.0	10.0	NUM
cajgh-29	78	100	)	)	PUNCT
cajgh-29	78	101	5	5	NUM
cajgh-29	78	102	(	(	PUNCT
cajgh-29	78	103	6.0	6.0	NUM
cajgh-29	78	104	)	)	PUNCT
cajgh-29	78	105	40	40	NUM
cajgh-29	78	106	(	(	PUNCT
cajgh-29	78	107	35.7	35.7	NUM
cajgh-29	78	108	)	)	PUNCT
cajgh-29	78	109	124	124	NUM
cajgh-29	78	110	(	(	PUNCT
cajgh-29	78	111	46.2	46.2	NUM
cajgh-29	78	112	)	)	PUNCT
cajgh-29	78	113	t	t	NOUN
cajgh-29	78	114	–	–	PUNCT
cajgh-29	78	115	primary	primary	ADJ
cajgh-29	78	116	tumor	tumor	NOUN
cajgh-29	78	117	:	:	PUNCT
cajgh-29	78	118	t1	t1	NOUN
cajgh-29	78	119	≤2	≤2	NOUN
cajgh-29	78	120	cm	cm	NOUN
cajgh-29	78	121	,	,	PUNCT
cajgh-29	78	122	t2	t2	NOUN
cajgh-29	78	123	–	–	PUNCT
cajgh-29	78	124	>	>	X
cajgh-29	78	125	2	2	NUM
cajgh-29	78	126	to	to	PART
cajgh-29	78	127	5	5	NUM
cajgh-29	78	128	cm	cm	NOUN
cajgh-29	78	129	,	,	PUNCT
cajgh-29	78	130	t3	t3	PROPN
cajgh-29	78	131	>	>	X
cajgh-29	78	132	5	5	NUM
cajgh-29	78	133	cm	cm	NOUN
cajgh-29	78	134	,	,	PUNCT
cajgh-29	78	135	t4	t4	PROPN
cajgh-29	78	136	–	–	PUNCT
cajgh-29	78	137	tumor	tumor	NOUN
cajgh-29	78	138	of	of	ADP
cajgh-29	78	139	any	any	DET
cajgh-29	78	140	size	size	NOUN
cajgh-29	78	141	with	with	ADP
cajgh-29	78	142	direct	direct	ADJ
cajgh-29	78	143	extension	extension	NOUN
cajgh-29	78	144	to	to	PART
cajgh-29	78	145	chest	chest	VERB
cajgh-29	78	146	wall	wall	NOUN
cajgh-29	78	147	or	or	CCONJ
cajgh-29	78	148	skin	skin	NOUN
cajgh-29	78	149	,	,	PUNCT
cajgh-29	78	150	n	n	CCONJ
cajgh-29	78	151	–	–	PUNCT
cajgh-29	78	152	regional	regional	ADJ
cajgh-29	78	153	lymph	lymph	NOUN
cajgh-29	78	154	nodes	node	NOUN
cajgh-29	78	155	,	,	PUNCT
cajgh-29	78	156	m	m	ADJ
cajgh-29	78	157	–	–	PUNCT
cajgh-29	78	158	distant	distant	ADJ
cajgh-29	78	159	metastasis	metastasis	NOUN
cajgh-29	78	160	*	*	PUNCT
cajgh-29	78	161	p<0.05	p<0.05	NOUN
cajgh-29	78	162	vs	vs	ADP
cajgh-29	78	163	controls	control	NOUN
cajgh-29	78	164	mutational	mutational	ADJ
cajgh-29	78	165	screening	screening	NOUN
cajgh-29	78	166	of	of	ADP
cajgh-29	78	167	brca1	brca1	PROPN
cajgh-29	78	168	and	and	CCONJ
cajgh-29	78	169	brca2	brca2	PROPN
cajgh-29	78	170	coding	code	VERB
cajgh-29	78	171	regions	region	NOUN
cajgh-29	78	172	was	be	AUX
cajgh-29	78	173	performed	perform	VERB
cajgh-29	78	174	for	for	ADP
cajgh-29	78	175	156	156	NUM
cajgh-29	78	176	sporadic	sporadic	ADJ
cajgh-29	78	177	breast	breast	NOUN
cajgh-29	78	178	cancer	cancer	NOUN
cajgh-29	78	179	cases	case	NOUN
cajgh-29	78	180	and	and	CCONJ
cajgh-29	78	181	112	112	NUM
cajgh-29	78	182	controls	control	NOUN
cajgh-29	78	183	.	.	PUNCT
cajgh-29	79	1	mutation	mutation	NOUN
cajgh-29	79	2	analysis	analysis	NOUN
cajgh-29	79	3	of	of	ADP
cajgh-29	79	4	the	the	DET
cajgh-29	79	5	brca1	brca1	NOUN
cajgh-29	79	6	and	and	CCONJ
cajgh-29	79	7	brca2	brca2	NOUN
cajgh-29	79	8	genes	gene	NOUN
cajgh-29	79	9	revealed	reveal	VERB
cajgh-29	79	10	the	the	DET
cajgh-29	79	11	presence	presence	NOUN
cajgh-29	79	12	of	of	ADP
cajgh-29	79	13	22	22	NUM
cajgh-29	79	14	distinct	distinct	ADJ
cajgh-29	79	15	variants	variant	NOUN
cajgh-29	79	16	,	,	PUNCT
cajgh-29	79	17	including	include	VERB
cajgh-29	79	18	16	16	NUM
cajgh-29	79	19	missense	missense	NOUN
cajgh-29	79	20	mutations	mutation	NOUN
cajgh-29	79	21	and	and	CCONJ
cajgh-29	79	22	6	6	NUM
cajgh-29	79	23	polymorphisms	polymorphism	NOUN
cajgh-29	79	24	(	(	PUNCT
cajgh-29	79	25	tables	table	NOUN
cajgh-29	79	26	2	2	NUM
cajgh-29	79	27	and	and	CCONJ
cajgh-29	79	28	3	3	NUM
cajgh-29	79	29	)	)	PUNCT
cajgh-29	79	30	.	.	PUNCT
cajgh-29	80	1	the	the	DET
cajgh-29	80	2	sequence	sequence	NOUN
cajgh-29	80	3	variants	variant	NOUN
cajgh-29	80	4	identified	identify	VERB
cajgh-29	80	5	in	in	ADP
cajgh-29	80	6	brca1	brca1	PROPN
cajgh-29	80	7	gene	gene	NOUN
cajgh-29	80	8	9	9	NUM
cajgh-29	80	9	missense	missense	NOUN
cajgh-29	80	10	mutations	mutation	NOUN
cajgh-29	80	11	–	–	PUNCT
cajgh-29	80	12	c.95g	c.95g	NOUN
cajgh-29	80	13	>	>	X
cajgh-29	80	14	t	t	PROPN
cajgh-29	80	15	(	(	PUNCT
cajgh-29	80	16	g32v	g32v	NOUN
cajgh-29	80	17	)	)	PUNCT
cajgh-29	80	18	,	,	PUNCT
cajgh-29	80	19	c.254a	c.254a	PROPN
cajgh-29	80	20	>	>	SYM
cajgh-29	80	21	g	g	PROPN
cajgh-29	80	22	(	(	PUNCT
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cajgh-29	80	29	(	(	PUNCT
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cajgh-29	80	43	(	(	PUNCT
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cajgh-29	80	46	)	)	PUNCT
cajgh-29	80	47	,	,	PUNCT
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cajgh-29	80	51	(	(	PUNCT
cajgh-29	80	52	k1183r	k1183r	PROPN
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cajgh-29	80	60	)	)	PUNCT
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cajgh-29	80	68	)	)	PUNCT
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cajgh-29	80	71	>	>	X
cajgh-29	80	72	g	g	PROPN
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cajgh-29	80	82	,	,	PUNCT
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cajgh-29	80	86	.	.	PUNCT
cajgh-29	81	1	most	most	ADJ
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cajgh-29	81	3	these	these	DET
cajgh-29	81	4	polymorphisms	polymorphism	NOUN
cajgh-29	81	5	were	be	AUX
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cajgh-29	81	8	exon	exon	NOUN
cajgh-29	81	9	11	11	NUM
cajgh-29	81	10	of	of	ADP
cajgh-29	81	11	brca1	brca1	PROPN
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cajgh-29	81	16	%	%	NOUN
cajgh-29	81	17	of	of	ADP
cajgh-29	81	18	all	all	DET
cajgh-29	81	19	brca1	brca1	NOUN
cajgh-29	81	20	coding	code	VERB
cajgh-29	81	21	region	region	NOUN
cajgh-29	81	22	.	.	PUNCT
cajgh-29	82	1	figure	figure	VERB
cajgh-29	82	2	1	1	NUM
cajgh-29	82	3	:	:	PUNCT
cajgh-29	82	4	detection	detection	NOUN
cajgh-29	82	5	of	of	ADP
cajgh-29	82	6	the	the	DET
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cajgh-29	82	8	variants	variant	NOUN
cajgh-29	82	9	in	in	ADP
cajgh-29	82	10	11	11	NUM
cajgh-29	82	11	exon	exon	NOUN
cajgh-29	82	12	of	of	ADP
cajgh-29	82	13	brca1	brca1	PROPN
cajgh-29	82	14	.	.	PROPN
cajgh-29	82	15	table	table	NOUN
cajgh-29	82	16	2	2	NUM
cajgh-29	82	17	:	:	PUNCT
cajgh-29	82	18	details	detail	NOUN
cajgh-29	82	19	and	and	CCONJ
cajgh-29	82	20	the	the	DET
cajgh-29	82	21	frequency	frequency	NOUN
cajgh-29	82	22	of	of	ADP
cajgh-29	82	23	the	the	DET
cajgh-29	82	24	variants	variant	NOUN
cajgh-29	82	25	detected	detect	VERB
cajgh-29	82	26	in	in	ADP
cajgh-29	82	27	the	the	DET
cajgh-29	82	28	brca1	brca1	NOUN
cajgh-29	82	29	in	in	ADP
cajgh-29	82	30	breast	breast	NOUN
cajgh-29	82	31	cancer	cancer	NOUN
cajgh-29	82	32	and	and	CCONJ
cajgh-29	82	33	control	control	NOUN
cajgh-29	82	34	groups	group	NOUN
cajgh-29	82	35	.	.	PUNCT
cajgh-29	83	1	exon	exon	ADJ
cajgh-29	83	2	sequence	sequence	NOUN
cajgh-29	83	3	variant	variant	ADJ
cajgh-29	83	4	amino	amino	NOUN
cajgh-29	83	5	acid	acid	NOUN
cajgh-29	83	6	variant	variant	NOUN
cajgh-29	83	7	frequency	frequency	NOUN
cajgh-29	83	8	in	in	ADP
cajgh-29	83	9	the	the	DET
cajgh-29	83	10	breast	breast	NOUN
cajgh-29	83	11	cancer	cancer	NOUN
cajgh-29	83	12	group	group	NOUN
cajgh-29	83	13	(	(	PUNCT
cajgh-29	83	14	n=156	n=156	PROPN
cajgh-29	83	15	)	)	PUNCT
cajgh-29	83	16	,	,	PUNCT
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cajgh-29	83	18	(	(	PUNCT
cajgh-29	83	19	%	%	INTJ
cajgh-29	83	20	)	)	PUNCT
cajgh-29	83	21	frequency	frequency	NOUN
cajgh-29	83	22	in	in	ADP
cajgh-29	83	23	the	the	DET
cajgh-29	83	24	control	control	NOUN
cajgh-29	83	25	group	group	NOUN
cajgh-29	83	26	(	(	PUNCT
cajgh-29	83	27	n=112	n=112	PROPN
cajgh-29	83	28	)	)	PUNCT
cajgh-29	83	29	,	,	PUNCT
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cajgh-29	83	31	(	(	PUNCT
cajgh-29	83	32	%	%	INTJ
cajgh-29	83	33	)	)	PUNCT
cajgh-29	83	34	bic	bic	PROPN
cajgh-29	83	35	entry	entry	NOUN
cajgh-29	83	36	total	total	ADJ
cajgh-29	83	37	caucasian	caucasian	ADJ
cajgh-29	83	38	/	/	SYM
cajgh-29	83	39	asian	asian	ADJ
cajgh-29	83	40	total	total	ADJ
cajgh-29	83	41	caucasian	caucasian	ADJ
cajgh-29	83	42	/	/	SYM
cajgh-29	83	43	asian	asian	ADJ
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cajgh-29	83	45	mutations	mutation	NOUN
cajgh-29	83	46	2	2	NUM
cajgh-29	83	47	c.95(g	c.95(g	PROPN
cajgh-29	83	48	>	>	PROPN
cajgh-29	83	49	t	t	PROPN
cajgh-29	83	50	)	)	PUNCT
cajgh-29	83	51	†	†	PROPN
cajgh-29	83	52	(	(	PUNCT
cajgh-29	83	53	214g	214g	PROPN
cajgh-29	83	54	>	>	SYM
cajgh-29	83	55	t	t	PROPN
cajgh-29	83	56	)	)	PUNCT
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cajgh-29	83	61	)	)	PUNCT
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cajgh-29	83	63	)	)	PUNCT
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cajgh-29	83	67	)	)	PUNCT
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cajgh-29	83	70	)	)	PUNCT
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cajgh-29	83	73	)	)	PUNCT
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cajgh-29	83	76	3	3	NUM
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cajgh-29	83	80	)	)	PUNCT
cajgh-29	83	81	(	(	PUNCT
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cajgh-29	83	83	>	>	SYM
cajgh-29	83	84	g	g	NOUN
cajgh-29	83	85	)	)	PUNCT
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cajgh-29	83	87	(	(	PUNCT
cajgh-29	83	88	n85s	n85	NOUN
cajgh-29	83	89	)	)	PUNCT
cajgh-29	83	90	83	83	NUM
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cajgh-29	83	93	)	)	PUNCT
cajgh-29	83	94	*	*	PUNCT
cajgh-29	83	95	48(57.8)/	48(57.8)/	NOUN
cajgh-29	83	96	35(42.2	35(42.2	X
cajgh-29	83	97	)	)	PUNCT
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cajgh-29	83	100	)	)	PUNCT
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cajgh-29	83	102	27(64.3	27(64.3	NOUN
cajgh-29	83	103	)	)	PUNCT
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cajgh-29	83	110	(	(	PUNCT
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cajgh-29	83	118	)	)	PUNCT
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cajgh-29	83	122	)	)	PUNCT
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cajgh-29	83	124	5(45.4	5(45.4	NOUN
cajgh-29	83	125	)	)	PUNCT
cajgh-29	83	126	10	10	NUM
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cajgh-29	83	129	)	)	PUNCT
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cajgh-29	83	132	)	)	PUNCT
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cajgh-29	84	5	t	t	PROPN
cajgh-29	84	6	)	)	PUNCT
cajgh-29	84	7	(	(	PUNCT
cajgh-29	84	8	2731c	2731c	NUM
cajgh-29	84	9	>	>	SYM
cajgh-29	84	10	t	t	PROPN
cajgh-29	84	11	)	)	PUNCT
cajgh-29	84	12	p.pro871leu	p.pro871leu	PROPN
cajgh-29	84	13	(	(	PUNCT
cajgh-29	84	14	p871l	p871l	PROPN
cajgh-29	84	15	)	)	PUNCT
cajgh-29	84	16	87(55.8	87(55.8	NUM
cajgh-29	84	17	)	)	PUNCT
cajgh-29	84	18	53(60.9)/	53(60.9)/	ADJ
cajgh-29	84	19	34(39.1	34(39.1	NUM
cajgh-29	84	20	)	)	PUNCT
cajgh-29	84	21	#	#	NOUN
cajgh-29	84	22	54(48.2	54(48.2	NUM
cajgh-29	84	23	)	)	PUNCT
cajgh-29	84	24	20(37.0)/	20(37.0)/	NOUN
cajgh-29	84	25	34(63.0	34(63.0	NUM
cajgh-29	84	26	)	)	PUNCT
cajgh-29	84	27	#	#	NOUN
cajgh-29	85	1	yes	yes	NOUN
cajgh-29	85	2	11	11	NUM
cajgh-29	85	3	c.3113(a	c.3113(a	X
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cajgh-29	85	5	g	g	NOUN
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cajgh-29	85	7	(	(	PUNCT
cajgh-29	85	8	3232a	3232a	NUM
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cajgh-29	85	16	)	)	PUNCT
cajgh-29	85	17	88(56.6	88(56.6	ADJ
cajgh-29	85	18	)	)	PUNCT
cajgh-29	85	19	55(62.5)/	55(62.5)/	PROPN
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cajgh-29	85	21	)	)	PUNCT
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cajgh-29	85	24	)	)	PUNCT
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cajgh-29	85	41	(	(	PUNCT
cajgh-29	85	42	k1183r	k1183r	NOUN
cajgh-29	85	43	)	)	PUNCT
cajgh-29	85	44	92(59.0	92(59.0	NUM
cajgh-29	85	45	)	)	PUNCT
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cajgh-29	85	49	)	)	PUNCT
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cajgh-29	85	51	51(45.5	51(45.5	NUM
cajgh-29	85	52	)	)	PUNCT
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cajgh-29	85	54	34(66.7	34(66.7	NOUN
cajgh-29	85	55	)	)	PUNCT
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cajgh-29	85	72	)	)	PUNCT
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cajgh-29	85	75	)	)	PUNCT
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cajgh-29	85	77	(	(	PUNCT
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cajgh-29	85	79	)	)	PUNCT
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cajgh-29	85	82	)	)	PUNCT
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cajgh-29	86	6	(	(	PUNCT
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cajgh-29	86	9	g	g	NOUN
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cajgh-29	86	18	9(42.8)/	9(42.8)/	NUM
cajgh-29	86	19	12(57.1	12(57.1	NOUN
cajgh-29	86	20	)	)	PUNCT
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cajgh-29	86	26	10(50.0)/	10(50.0)/	NOUN
cajgh-29	86	27	10(50.0	10(50.0	NUM
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cajgh-29	87	4	(	(	PUNCT
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cajgh-29	87	12	g	g	NOUN
cajgh-29	87	13	)	)	PUNCT
cajgh-29	87	14	23(14.8	23(14.8	NUM
cajgh-29	87	15	)	)	PUNCT
cajgh-29	87	16	12(52.2)/	12(52.2)/	NUM
cajgh-29	87	17	11(47.8	11(47.8	NOUN
cajgh-29	87	18	)	)	PUNCT
cajgh-29	87	19	17	17	NUM
cajgh-29	87	20	(	(	PUNCT
cajgh-29	87	21	15.2	15.2	NUM
cajgh-29	87	22	)	)	PUNCT
cajgh-29	87	23	9(52.9)/	9(52.9)/	NOUN
cajgh-29	87	24	8(47.1	8(47.1	NUM
cajgh-29	87	25	)	)	PUNCT
cajgh-29	87	26	yes	yes	PRON
cajgh-29	87	27	polymorphisms	polymorphism	NOUN
cajgh-29	87	28	11	11	NUM
cajgh-29	87	29	c.2082(c	c.2082(c	PROPN
cajgh-29	87	30	>	>	X
cajgh-29	87	31	t	t	PROPN
cajgh-29	87	32	)	)	PUNCT
cajgh-29	87	33	(	(	PUNCT
cajgh-29	87	34	2201c	2201c	NUM
cajgh-29	87	35	>	>	X
cajgh-29	87	36	t	t	PROPN
cajgh-29	87	37	)	)	PUNCT
cajgh-29	87	38	synonymous	synonymous	ADJ
cajgh-29	87	39	ser694ser	ser694ser	NOUN
cajgh-29	87	40	(	(	PUNCT
cajgh-29	87	41	s694s	s694s	PROPN
cajgh-29	87	42	)	)	PUNCT
cajgh-29	87	43	45(54.2	45(54.2	NOUN
cajgh-29	87	44	)	)	PUNCT
cajgh-29	87	45	28(62.2)/	28(62.2)/	NUM
cajgh-29	87	46	17(37.8	17(37.8	NOUN
cajgh-29	87	47	)	)	PUNCT
cajgh-29	87	48	#	#	NOUN
cajgh-29	87	49	48(42.8	48(42.8	ADJ
cajgh-29	87	50	)	)	PUNCT
cajgh-29	87	51	17(35.4)/	17(35.4)/	NUM
cajgh-29	87	52	31(64.6	31(64.6	NOUN
cajgh-29	87	53	)	)	PUNCT
cajgh-29	87	54	#	#	NOUN
cajgh-29	88	1	yes	yes	NOUN
cajgh-29	88	2	11	11	NUM
cajgh-29	88	3	c.2311(t	c.2311(t	NOUN
cajgh-29	88	4	>	>	X
cajgh-29	88	5	c	c	X
cajgh-29	88	6	)	)	PUNCT
cajgh-29	88	7	(	(	PUNCT
cajgh-29	88	8	2430t	2430t	NOUN
cajgh-29	88	9	>	>	X
cajgh-29	88	10	c	c	X
cajgh-29	88	11	)	)	PUNCT
cajgh-29	88	12	synonymous	synonymous	ADJ
cajgh-29	88	13	leu771leu	leu771leu	PROPN
cajgh-29	88	14	(	(	PUNCT
cajgh-29	88	15	l771l	l771l	PROPN
cajgh-29	88	16	)	)	PUNCT
cajgh-29	88	17	45(54.2	45(54.2	NOUN
cajgh-29	88	18	)	)	PUNCT
cajgh-29	88	19	28(62.2)/	28(62.2)/	NUM
cajgh-29	88	20	17(37.8	17(37.8	NOUN
cajgh-29	88	21	)	)	PUNCT
cajgh-29	88	22	#	#	NOUN
cajgh-29	88	23	48(42.8	48(42.8	ADJ
cajgh-29	88	24	)	)	PUNCT
cajgh-29	88	25	17(35.4)/	17(35.4)/	NUM
cajgh-29	88	26	31(64.6	31(64.6	NOUN
cajgh-29	88	27	)	)	PUNCT
cajgh-29	88	28	#	#	NOUN
cajgh-29	88	29	yes	yes	NOUN
cajgh-29	88	30	13	13	NUM
cajgh-29	88	31	c.4427(t	c.4427(t	NOUN
cajgh-29	88	32	>	>	X
cajgh-29	88	33	c	c	NOUN
cajgh-29	88	34	)	)	PUNCT
cajgh-29	88	35	(	(	PUNCT
cajgh-29	88	36	4546t	4546t	NOUN
cajgh-29	88	37	>	>	SYM
cajgh-29	88	38	c	c	X
cajgh-29	88	39	)	)	PUNCT
cajgh-29	88	40	synonymous	synonymous	ADJ
cajgh-29	88	41	ser1436ser	ser1436ser	NOUN
cajgh-29	88	42	(	(	PUNCT
cajgh-29	88	43	s1436s	s1436s	NOUN
cajgh-29	88	44	)	)	PUNCT
cajgh-29	88	45	76(49.0	76(49.0	NOUN
cajgh-29	88	46	)	)	PUNCT
cajgh-29	88	47	35(46.0)/	35(46.0)/	NUM
cajgh-29	88	48	41(53.9	41(53.9	NOUN
cajgh-29	88	49	)	)	PUNCT
cajgh-29	88	50	#	#	NOUN
cajgh-29	88	51	54(48.2	54(48.2	NUM
cajgh-29	88	52	)	)	PUNCT
cajgh-29	88	53	25(46.3)/	25(46.3)/	NUM
cajgh-29	88	54	29(53.7	29(53.7	NOUN
cajgh-29	88	55	)	)	PUNCT
cajgh-29	88	56	yes	ye	VERB
cajgh-29	88	57	†	†	NOUN
cajgh-29	88	58	numbering	numbering	NOUN
cajgh-29	88	59	according	accord	VERB
cajgh-29	88	60	to	to	ADP
cajgh-29	88	61	genbank	genbank	PROPN
cajgh-29	88	62	accession	accession	NOUN
cajgh-29	88	63	no	no	PROPN
cajgh-29	88	64	.	.	PROPN
cajgh-29	88	65	nm_007294.1	nm_007294.1	PROPN
cajgh-29	88	66	,	,	PUNCT
cajgh-29	88	67	the	the	DET
cajgh-29	88	68	a	a	PRON
cajgh-29	88	69	of	of	ADP
cajgh-29	88	70	the	the	DET
cajgh-29	88	71	atg	atg	PROPN
cajgh-29	88	72	translation	translation	NOUN
cajgh-29	88	73	initiation	initiation	NOUN
cajgh-29	88	74	codon	codon	PROPN
cajgh-29	88	75	is	be	AUX
cajgh-29	88	76	+1,according	+1,accorde	VERB
cajgh-29	88	77	to	to	ADP
cajgh-29	88	78	approved	approve	VERB
cajgh-29	88	79	guidelines	guideline	NOUN
cajgh-29	88	80	(	(	PUNCT
cajgh-29	88	81	http://www.hgvs.org/mutnomen/	http://www.hgvs.org/mutnomen/	NOUN
cajgh-29	88	82	)	)	PUNCT
cajgh-29	88	83	‡the	‡the	DET
cajgh-29	88	84	nomenclature	nomenclature	NOUN
cajgh-29	88	85	as	as	SCONJ
cajgh-29	88	86	used	use	VERB
cajgh-29	88	87	in	in	ADP
cajgh-29	88	88	the	the	DET
cajgh-29	88	89	bic	bic	PROPN
cajgh-29	88	90	database	database	NOUN
cajgh-29	88	91	is	be	AUX
cajgh-29	88	92	given	give	VERB
cajgh-29	88	93	in	in	ADP
cajgh-29	88	94	parentheses	parenthesis	NOUN
cajgh-29	88	95	.	.	PUNCT
cajgh-29	89	1	mutation	mutation	NOUN
cajgh-29	89	2	nomenclature	nomenclature	NOUN
cajgh-29	89	3	is	be	AUX
cajgh-29	89	4	according	accord	VERB
cajgh-29	89	5	to	to	ADP
cajgh-29	89	6	refseq	refseq	NOUN
cajgh-29	89	7	accession	accession	NOUN
cajgh-29	89	8	number	number	NOUN
cajgh-29	89	9	u14680	u14680	PROPN
cajgh-29	89	10	(	(	PUNCT
cajgh-29	89	11	brca1	brca1	PROPN
cajgh-29	89	12	)	)	PUNCT
cajgh-29	89	13	with	with	ADP
cajgh-29	89	14	numbering	numbering	NOUN
cajgh-29	89	15	starting	start	VERB
cajgh-29	89	16	at	at	ADP
cajgh-29	89	17	the	the	DET
cajgh-29	89	18	a	a	NOUN
cajgh-29	89	19	of	of	ADP
cajgh-29	89	20	the	the	DET
cajgh-29	89	21	first	first	ADJ
cajgh-29	89	22	atg	atg	NOUN
cajgh-29	89	23	at	at	ADP
cajgh-29	89	24	the	the	DET
cajgh-29	89	25	position	position	NOUN
cajgh-29	89	26	120	120	NUM
cajgh-29	89	27	*	*	SYM
cajgh-29	89	28	p<0.05	p<0.05	NOUN
cajgh-29	89	29	,	,	PUNCT
cajgh-29	89	30	*	*	PUNCT
cajgh-29	89	31	*	*	PUNCT
cajgh-29	89	32	p<0.001	p<0.001	VERB
cajgh-29	89	33	between	between	ADP
cajgh-29	89	34	cases	case	NOUN
cajgh-29	89	35	and	and	CCONJ
cajgh-29	89	36	controls	control	VERB
cajgh-29	89	37	#	#	SYM
cajgh-29	89	38	p<0.05	p<0.05	NOUN
cajgh-29	89	39	,	,	PUNCT
cajgh-29	89	40	#	#	SYM
cajgh-29	89	41	#	#	NOUN
cajgh-29	89	42	-p<0.001	-p<0.001	NOUN
cajgh-29	89	43	between	between	ADP
cajgh-29	89	44	caucasians	caucasians	PROPN
cajgh-29	89	45	and	and	CCONJ
cajgh-29	89	46	asians	asians	PROPN
cajgh-29	89	47	in	in	ADP
cajgh-29	89	48	group	group	NOUN
cajgh-29	89	49	missense	missense	NOUN
cajgh-29	89	50	mutations	mutation	NOUN
cajgh-29	89	51	c.95g	c.95g	PROPN
cajgh-29	89	52	>	>	X
cajgh-29	89	53	t	t	PROPN
cajgh-29	89	54	(	(	PUNCT
cajgh-29	89	55	g32v	g32v	NOUN
cajgh-29	89	56	)	)	PUNCT
cajgh-29	89	57	,	,	PUNCT
cajgh-29	89	58	c.254a	c.254a	PROPN
cajgh-29	89	59	>	>	SYM
cajgh-29	89	60	g	g	PROPN
cajgh-29	89	61	(	(	PUNCT
cajgh-29	89	62	n85s	n85	NOUN
cajgh-29	89	63	)	)	PUNCT
cajgh-29	89	64	,	,	PUNCT
cajgh-29	89	65	c.3348a	c.3348a	X
cajgh-29	89	66	>	>	X
cajgh-29	89	67	g	g	PROPN
cajgh-29	89	68	(	(	PUNCT
cajgh-29	89	69	k1183r	k1183r	PROPN
cajgh-29	89	70	)	)	PUNCT
cajgh-29	89	71	were	be	AUX
cajgh-29	89	72	detected	detect	VERB
cajgh-29	89	73	with	with	ADP
cajgh-29	89	74	frequency	frequency	NOUN
cajgh-29	89	75	in	in	ADP
cajgh-29	89	76	54.1	54.1	NUM
cajgh-29	89	77	%	%	NOUN
cajgh-29	89	78	,	,	PUNCT
cajgh-29	89	79	53.0	53.0	NUM
cajgh-29	89	80	%	%	NOUN
cajgh-29	89	81	,	,	PUNCT
cajgh-29	89	82	59.0	59.0	NUM
cajgh-29	89	83	%	%	NOUN
cajgh-29	89	84	of	of	ADP
cajgh-29	89	85	cases	case	NOUN
cajgh-29	89	86	and	and	CCONJ
cajgh-29	89	87	43.7	43.7	NUM
cajgh-29	89	88	%	%	NOUN
cajgh-29	89	89	,	,	PUNCT
cajgh-29	89	90	37.5	37.5	NUM
cajgh-29	89	91	%	%	NOUN
cajgh-29	89	92	,	,	PUNCT
cajgh-29	89	93	45.5	45.5	NUM
cajgh-29	89	94	%	%	NOUN
cajgh-29	89	95	of	of	ADP
cajgh-29	89	96	controls	control	NOUN
cajgh-29	89	97	,	,	PUNCT
cajgh-29	89	98	respectively	respectively	ADV
cajgh-29	89	99	,	,	PUNCT
cajgh-29	89	100	showing	show	VERB
cajgh-29	89	101	significantly	significantly	ADV
cajgh-29	89	102	higher	high	ADJ
cajgh-29	89	103	prevalence	prevalence	NOUN
cajgh-29	89	104	in	in	ADP
cajgh-29	89	105	cases	case	NOUN
cajgh-29	89	106	(	(	PUNCT
cajgh-29	89	107	p<0.05	p<0.05	NOUN
cajgh-29	89	108	)	)	PUNCT
cajgh-29	89	109	.	.	PUNCT
cajgh-29	90	1	there	there	PRON
cajgh-29	90	2	was	be	VERB
cajgh-29	90	3	no	no	DET
cajgh-29	90	4	significant	significant	ADJ
cajgh-29	90	5	prevalence	prevalence	NOUN
cajgh-29	90	6	in	in	ADP
cajgh-29	90	7	frequency	frequency	NOUN
cajgh-29	90	8	of	of	ADP
cajgh-29	90	9	missense	missense	NOUN
cajgh-29	90	10	mutations	mutation	NOUN
cajgh-29	90	11	c.1067a	c.1067a	ADV
cajgh-29	90	12	>	>	X
cajgh-29	90	13	g	g	PROPN
cajgh-29	90	14	(	(	PUNCT
cajgh-29	90	15	q356r	q356r	PROPN
cajgh-29	90	16	)	)	PUNCT
cajgh-29	90	17	,	,	PUNCT
cajgh-29	90	18	c.2612c	c.2612c	PROPN
cajgh-29	90	19	>	>	X
cajgh-29	90	20	t	t	PROPN
cajgh-29	90	21	(	(	PUNCT
cajgh-29	90	22	p871l	p871l	PROPN
cajgh-29	90	23	)	)	PUNCT
cajgh-29	90	24	,	,	PUNCT
cajgh-29	90	25	c.3113a	c.3113a	NOUN
cajgh-29	90	26	>	>	X
cajgh-29	90	27	g	g	PROPN
cajgh-29	90	28	(	(	PUNCT
cajgh-29	90	29	e1038	e1038	PROPN
cajgh-29	90	30	g	g	NOUN
cajgh-29	90	31	)	)	PUNCT
cajgh-29	90	32	,	,	PUNCT
cajgh-29	90	33	c.4744c	c.4744c	ADV
cajgh-29	90	34	>	>	X
cajgh-29	90	35	g	g	PROPN
cajgh-29	90	36	(	(	PUNCT
cajgh-29	90	37	s1542c	s1542c	ADJ
cajgh-29	90	38	)	)	PUNCT
cajgh-29	90	39	,	,	PUNCT
cajgh-29	90	40	c.5397a	c.5397a	PROPN
cajgh-29	90	41	>	>	X
cajgh-29	90	42	g	g	PROPN
cajgh-29	90	43	(	(	PUNCT
cajgh-29	90	44	a1627	a1627	NOUN
cajgh-29	90	45	g	g	NOUN
cajgh-29	90	46	)	)	PUNCT
cajgh-29	90	47	in	in	ADP
cajgh-29	90	48	cases	case	NOUN
cajgh-29	90	49	comparing	compare	VERB
cajgh-29	90	50	to	to	ADP
cajgh-29	90	51	controls	control	NOUN
cajgh-29	90	52	.	.	PUNCT
cajgh-29	91	1	synonymous	synonymous	ADJ
cajgh-29	91	2	polymorphisms	polymorphism	NOUN
cajgh-29	91	3	s694s	s694s	PROPN
cajgh-29	91	4	and	and	CCONJ
cajgh-29	91	5	l771l	l771l	PROPN
cajgh-29	91	6	were	be	AUX
cajgh-29	91	7	detected	detect	VERB
cajgh-29	91	8	in	in	ADP
cajgh-29	91	9	45	45	NUM
cajgh-29	91	10	(	(	PUNCT
cajgh-29	91	11	54.2	54.2	NUM
cajgh-29	91	12	%	%	NOUN
cajgh-29	91	13	)	)	PUNCT
cajgh-29	91	14	of	of	ADP
cajgh-29	91	15	cases	case	NOUN
cajgh-29	91	16	and	and	CCONJ
cajgh-29	91	17	48	48	NUM
cajgh-29	91	18	(	(	PUNCT
cajgh-29	91	19	42.8	42.8	NUM
cajgh-29	91	20	%	%	NOUN
cajgh-29	91	21	)	)	PUNCT
cajgh-29	91	22	controls	control	NOUN
cajgh-29	91	23	.	.	PUNCT
cajgh-29	92	1	s1436s	s1436s	NOUN
cajgh-29	92	2	was	be	AUX
cajgh-29	92	3	found	find	VERB
cajgh-29	92	4	in	in	ADP
cajgh-29	92	5	76	76	NUM
cajgh-29	92	6	(	(	PUNCT
cajgh-29	92	7	49.0	49.0	NUM
cajgh-29	92	8	%	%	NOUN
cajgh-29	92	9	)	)	PUNCT
cajgh-29	92	10	cases	case	NOUN
cajgh-29	92	11	and	and	CCONJ
cajgh-29	92	12	54	54	NUM
cajgh-29	92	13	(	(	PUNCT
cajgh-29	92	14	48.2	48.2	NUM
cajgh-29	92	15	%	%	NOUN
cajgh-29	92	16	)	)	PUNCT
cajgh-29	92	17	controls	control	NOUN
cajgh-29	92	18	.	.	PUNCT
cajgh-29	93	1	in	in	ADP
cajgh-29	93	2	brca2	brca2	PROPN
cajgh-29	93	3	,	,	PUNCT
cajgh-29	93	4	gene	gene	NOUN
cajgh-29	93	5	missense	missense	NOUN
cajgh-29	93	6	mutations	mutation	NOUN
cajgh-29	93	7	c.865a	c.865a	X
cajgh-29	93	8	>	>	X
cajgh-29	93	9	c	c	X
cajgh-29	93	10	(	(	PUNCT
cajgh-29	93	11	n289h	n289h	PROPN
cajgh-29	93	12	)	)	PUNCT
cajgh-29	93	13	,	,	PUNCT
cajgh-29	93	14	c.10234a	c.10234a	PROPN
cajgh-29	93	15	>	>	X
cajgh-29	93	16	g	g	PROPN
cajgh-29	93	17	(	(	PUNCT
cajgh-29	93	18	i3412v	i3412v	NOUN
cajgh-29	93	19	)	)	PUNCT
cajgh-29	93	20	were	be	AUX
cajgh-29	93	21	detected	detect	VERB
cajgh-29	93	22	with	with	ADP
cajgh-29	93	23	higher	high	ADJ
cajgh-29	93	24	frequency	frequency	NOUN
cajgh-29	93	25	in	in	ADP
cajgh-29	93	26	15.2	15.2	NUM
cajgh-29	93	27	%	%	NOUN
cajgh-29	93	28	and	and	CCONJ
cajgh-29	93	29	30.8	30.8	NUM
cajgh-29	93	30	%	%	NOUN
cajgh-29	93	31	of	of	ADP
cajgh-29	93	32	cases	case	NOUN
cajgh-29	93	33	compared	compare	VERB
cajgh-29	93	34	to	to	ADP
cajgh-29	93	35	controls	control	NOUN
cajgh-29	93	36	(	(	PUNCT
cajgh-29	93	37	10.1	10.1	NUM
cajgh-29	93	38	%	%	NOUN
cajgh-29	93	39	,	,	PUNCT
cajgh-29	93	40	18.7	18.7	NUM
cajgh-29	93	41	%	%	NOUN
cajgh-29	93	42	,	,	PUNCT
cajgh-29	93	43	respectively	respectively	ADV
cajgh-29	93	44	,	,	PUNCT
cajgh-29	93	45	p<0.05	p<0.05	NOUN
cajgh-29	93	46	)	)	PUNCT
cajgh-29	93	47	.	.	PUNCT
cajgh-29	94	1	table	table	NOUN
cajgh-29	94	2	3	3	NUM
cajgh-29	94	3	:	:	PUNCT
cajgh-29	94	4	details	detail	NOUN
cajgh-29	94	5	and	and	CCONJ
cajgh-29	94	6	the	the	DET
cajgh-29	94	7	frequency	frequency	NOUN
cajgh-29	94	8	of	of	ADP
cajgh-29	94	9	the	the	DET
cajgh-29	94	10	variants	variant	NOUN
cajgh-29	94	11	detected	detect	VERB
cajgh-29	94	12	in	in	ADP
cajgh-29	94	13	the	the	DET
cajgh-29	94	14	brca2	brca2	NOUN
cajgh-29	94	15	in	in	ADP
cajgh-29	94	16	breast	breast	NOUN
cajgh-29	94	17	cancer	cancer	NOUN
cajgh-29	94	18	and	and	CCONJ
cajgh-29	94	19	control	control	NOUN
cajgh-29	94	20	groups	group	NOUN
cajgh-29	94	21	exon	exon	VERB
cajgh-29	94	22	sequence	sequence	NOUN
cajgh-29	94	23	variant	variant	ADJ
cajgh-29	94	24	amino	amino	NOUN
cajgh-29	94	25	acid	acid	NOUN
cajgh-29	94	26	variant	variant	NOUN
cajgh-29	94	27	frequency	frequency	NOUN
cajgh-29	94	28	in	in	ADP
cajgh-29	94	29	the	the	DET
cajgh-29	94	30	breast	breast	NOUN
cajgh-29	94	31	cancer	cancer	NOUN
cajgh-29	94	32	group	group	NOUN
cajgh-29	94	33	(	(	PUNCT
cajgh-29	94	34	n=156	n=156	PROPN
cajgh-29	94	35	)	)	PUNCT
cajgh-29	94	36	,	,	PUNCT
cajgh-29	94	37	abs	ab	NOUN
cajgh-29	94	38	(	(	PUNCT
cajgh-29	94	39	%	%	INTJ
cajgh-29	94	40	)	)	PUNCT
cajgh-29	94	41	frequency	frequency	NOUN
cajgh-29	94	42	in	in	ADP
cajgh-29	94	43	the	the	DET
cajgh-29	94	44	control	control	NOUN
cajgh-29	94	45	group	group	NOUN
cajgh-29	94	46	(	(	PUNCT
cajgh-29	94	47	n=112	n=112	PROPN
cajgh-29	94	48	)	)	PUNCT
cajgh-29	94	49	,	,	PUNCT
cajgh-29	94	50	abs	ab	NOUN
cajgh-29	94	51	(	(	PUNCT
cajgh-29	94	52	%	%	INTJ
cajgh-29	94	53	)	)	PUNCT
cajgh-29	94	54	bic	bic	PROPN
cajgh-29	94	55	entry	entry	NOUN
cajgh-29	94	56	total	total	ADJ
cajgh-29	94	57	caucasian	caucasian	ADJ
cajgh-29	94	58	/	/	SYM
cajgh-29	94	59	asian	asian	ADJ
cajgh-29	94	60	total	total	ADJ
cajgh-29	94	61	caucasian	caucasian	ADJ
cajgh-29	94	62	/	/	SYM
cajgh-29	94	63	asian	asian	ADJ
cajgh-29	94	64	missense	missense	NOUN
cajgh-29	94	65	mutations	mutation	NOUN
cajgh-29	94	66	10	10	NUM
cajgh-29	94	67	c.865(a	c.865(a	PROPN
cajgh-29	94	68	>	>	SYM
cajgh-29	94	69	c)†	c)†	PROPN
cajgh-29	94	70	(	(	PUNCT
cajgh-29	94	71	1093a	1093a	NUM
cajgh-29	94	72	>	>	SYM
cajgh-29	94	73	c	c	X
cajgh-29	94	74	)	)	PUNCT
cajgh-29	94	75	‡	‡	VERB
cajgh-29	95	1	p.asn289his	p.asn289his	PROPN
cajgh-29	95	2	(	(	PUNCT
cajgh-29	95	3	n289h	n289h	NOUN
cajgh-29	95	4	)	)	PUNCT
cajgh-29	95	5	24(15.2	24(15.2	NOUN
cajgh-29	95	6	)	)	PUNCT
cajgh-29	95	7	*	*	PROPN
cajgh-29	95	8	13(54.2)/	13(54.2)/	NUM
cajgh-29	95	9	11(45.8	11(45.8	ADJ
cajgh-29	95	10	)	)	PUNCT
cajgh-29	95	11	11(10.1	11(10.1	NUM
cajgh-29	95	12	)	)	PUNCT
cajgh-29	95	13	7(63.6)/	7(63.6)/	NUM
cajgh-29	95	14	4(36.4	4(36.4	NUM
cajgh-29	95	15	)	)	PUNCT
cajgh-29	96	1	yes	yes	INTJ
cajgh-29	97	1	10	10	NUM
cajgh-29	97	2	c.2127(t	c.2127(t	PROPN
cajgh-29	97	3	>	>	X
cajgh-29	97	4	c	c	NOUN
cajgh-29	97	5	)	)	PUNCT
cajgh-29	97	6	(	(	PUNCT
cajgh-29	97	7	2235t	2235t	NOUN
cajgh-29	97	8	>	>	SYM
cajgh-29	97	9	c	c	X
cajgh-29	97	10	)	)	PUNCT
cajgh-29	97	11	p.asn709arg	p.asn709arg	NOUN
cajgh-29	97	12	(	(	PUNCT
cajgh-29	97	13	n709r	n709r	ADV
cajgh-29	97	14	)	)	PUNCT
cajgh-29	97	15	65(41.6	65(41.6	NOUN
cajgh-29	97	16	)	)	PUNCT
cajgh-29	97	17	*	*	PUNCT
cajgh-29	97	18	36(55.4)/	36(55.4)/	NUM
cajgh-29	97	19	29(44.6	29(44.6	NUM
cajgh-29	97	20	)	)	PUNCT
cajgh-29	97	21	#	#	NOUN
cajgh-29	97	22	52(46.4	52(46.4	NUM
cajgh-29	97	23	)	)	PUNCT
cajgh-29	97	24	29(55.8)/	29(55.8)/	NUM
cajgh-29	97	25	23(44.2	23(44.2	NOUN
cajgh-29	97	26	)	)	PUNCT
cajgh-29	98	1	yes	yes	INTJ
cajgh-29	98	2	11	11	NUM
cajgh-29	99	1	c.2350(a	c.2350(a	NOUN
cajgh-29	99	2	>	>	NOUN
cajgh-29	99	3	g	g	NOUN
cajgh-29	99	4	)	)	PUNCT
cajgh-29	99	5	(	(	PUNCT
cajgh-29	99	6	2578a	2578a	NUM
cajgh-29	99	7	>	>	SYM
cajgh-29	99	8	g	g	NOUN
cajgh-29	99	9	)	)	PUNCT
cajgh-29	99	10	p.met784val	p.met784val	NOUN
cajgh-29	99	11	(	(	PUNCT
cajgh-29	99	12	m784v	m784v	PROPN
cajgh-29	99	13	)	)	PUNCT
cajgh-29	99	14	26(17.0	26(17.0	NUM
cajgh-29	99	15	)	)	PUNCT
cajgh-29	99	16	16(61.5)/	16(61.5)/	NUM
cajgh-29	99	17	10(38.5	10(38.5	NUM
cajgh-29	99	18	)	)	PUNCT
cajgh-29	99	19	#	#	NOUN
cajgh-29	99	20	24(21.4	24(21.4	NOUN
cajgh-29	99	21	)	)	PUNCT
cajgh-29	99	22	13(54.2)/	13(54.2)/	NOUN
cajgh-29	99	23	11(45.8	11(45.8	NOUN
cajgh-29	99	24	)	)	PUNCT
cajgh-29	100	1	yes	yes	ADV
cajgh-29	100	2	11	11	NUM
cajgh-29	101	1	c.2410(g	c.2410(g	NOUN
cajgh-29	101	2	>	>	X
cajgh-29	101	3	a	a	NOUN
cajgh-29	101	4	)	)	PUNCT
cajgh-29	101	5	(	(	PUNCT
cajgh-29	101	6	2638g	2638g	NOUN
cajgh-29	101	7	>	>	SYM
cajgh-29	101	8	a	a	PRON
cajgh-29	101	9	)	)	PUNCT
cajgh-29	101	10	p.asp804asn	p.asp804asn	NOUN
cajgh-29	101	11	(	(	PUNCT
cajgh-29	101	12	d804n	d804n	PROPN
cajgh-29	101	13	)	)	PUNCT
cajgh-29	101	14	54(34.7	54(34.7	NOUN
cajgh-29	101	15	)	)	PUNCT
cajgh-29	101	16	33(61.1)/	33(61.1)/	NOUN
cajgh-29	101	17	21(38.9	21(38.9	NOUN
cajgh-29	101	18	)	)	PUNCT
cajgh-29	101	19	#	#	NOUN
cajgh-29	101	20	38	38	NUM
cajgh-29	101	21	(	(	PUNCT
cajgh-29	101	22	33.9	33.9	NUM
cajgh-29	101	23	)	)	PUNCT
cajgh-29	101	24	16(42.1)/	16(42.1)/	NOUN
cajgh-29	101	25	22(57.9	22(57.9	NUM
cajgh-29	101	26	)	)	PUNCT
cajgh-29	102	1	yes	yes	INTJ
cajgh-29	102	2	11	11	NUM
cajgh-29	102	3	c.3422(t	c.3422(t	PROPN
cajgh-29	102	4	>	>	X
cajgh-29	102	5	c	c	NOUN
cajgh-29	102	6	)	)	PUNCT
cajgh-29	102	7	(	(	PUNCT
cajgh-29	102	8	3650t	3650t	NUM
cajgh-29	102	9	>	>	SYM
cajgh-29	102	10	c	c	X
cajgh-29	102	11	)	)	PUNCT
cajgh-29	102	12	p.ile1141thr	p.ile1141thr	PROPN
cajgh-29	102	13	(	(	PUNCT
cajgh-29	102	14	i1141	i1141	PROPN
cajgh-29	102	15	t	t	PROPN
cajgh-29	102	16	)	)	PUNCT
cajgh-29	102	17	39(24.9	39(24.9	NUM
cajgh-29	102	18	)	)	PUNCT
cajgh-29	102	19	15(38.5)/	15(38.5)/	NUM
cajgh-29	102	20	14(35.9	14(35.9	NOUN
cajgh-29	102	21	)	)	PUNCT
cajgh-29	102	22	26	26	NUM
cajgh-29	102	23	(	(	PUNCT
cajgh-29	102	24	23.2	23.2	NUM
cajgh-29	102	25	)	)	PUNCT
cajgh-29	102	26	16(61.5)/	16(61.5)/	NUM
cajgh-29	102	27	10(38.5	10(38.5	NUM
cajgh-29	102	28	)	)	PUNCT
cajgh-29	102	29	#	#	NOUN
cajgh-29	102	30	yes	yes	NOUN
cajgh-29	102	31	11	11	NUM
cajgh-29	102	32	c.3572(c	c.3572(c	PROPN
cajgh-29	102	33	>	>	X
cajgh-29	102	34	t	t	PROPN
cajgh-29	102	35	)	)	PUNCT
cajgh-29	102	36	(	(	PUNCT
cajgh-29	102	37	3800c	3800c	NUM
cajgh-29	102	38	>	>	SYM
cajgh-29	102	39	t	t	PROPN
cajgh-29	102	40	)	)	PUNCT
cajgh-29	102	41	p.ser1191phe	p.ser1191phe	NOUN
cajgh-29	102	42	(	(	PUNCT
cajgh-29	102	43	s1191f	s1191f	NOUN
cajgh-29	102	44	)	)	PUNCT
cajgh-29	102	45	34(21.8	34(21.8	NUM
cajgh-29	102	46	)	)	PUNCT
cajgh-29	102	47	15(44.1)/	15(44.1)/	NOUN
cajgh-29	102	48	19(55.9	19(55.9	NOUN
cajgh-29	102	49	)	)	PUNCT
cajgh-29	102	50	#	#	NOUN
cajgh-29	102	51	23	23	NUM
cajgh-29	102	52	(	(	PUNCT
cajgh-29	102	53	20.5	20.5	NUM
cajgh-29	102	54	)	)	PUNCT
cajgh-29	102	55	10(43.5)/	10(43.5)/	NOUN
cajgh-29	102	56	13(56.5	13(56.5	NUM
cajgh-29	102	57	)	)	PUNCT
cajgh-29	102	58	yes	yes	INTJ
cajgh-29	102	59	27	27	NUM
cajgh-29	102	60	c.10234(a	c.10234(a	NOUN
cajgh-29	102	61	>	>	NOUN
cajgh-29	102	62	g	g	NOUN
cajgh-29	102	63	)	)	PUNCT
cajgh-29	102	64	(	(	PUNCT
cajgh-29	102	65	10462a	10462a	NUM
cajgh-29	102	66	>	>	SYM
cajgh-29	102	67	g	g	PROPN
cajgh-29	102	68	)	)	PUNCT
cajgh-29	102	69	p.ile3412val	p.ile3412val	PROPN
cajgh-29	102	70	(	(	PUNCT
cajgh-29	102	71	i3412v	i3412v	PROPN
cajgh-29	102	72	)	)	PUNCT
cajgh-29	102	73	48	48	NUM
cajgh-29	102	74	(	(	PUNCT
cajgh-29	102	75	30.8	30.8	NUM
cajgh-29	102	76	)	)	PUNCT
cajgh-29	102	77	*	*	PUNCT
cajgh-29	102	78	29(60.4)/	29(60.4)/	PROPN
cajgh-29	102	79	19(39.6	19(39.6	NOUN
cajgh-29	102	80	)	)	PUNCT
cajgh-29	102	81	#	#	NOUN
cajgh-29	102	82	21	21	NUM
cajgh-29	102	83	(	(	PUNCT
cajgh-29	102	84	18.7	18.7	NUM
cajgh-29	102	85	)	)	PUNCT
cajgh-29	102	86	10(47.6)/	10(47.6)/	NOUN
cajgh-29	102	87	11(52.4	11(52.4	NUM
cajgh-29	102	88	)	)	PUNCT
cajgh-29	103	1	yes	yes	PRON
cajgh-29	103	2	polymorphisms	polymorphism	NOUN
cajgh-29	103	3	10	10	NUM
cajgh-29	103	4	c.1365(a	c.1365(a	NOUN
cajgh-29	103	5	>	>	NOUN
cajgh-29	103	6	g	g	NOUN
cajgh-29	103	7	)	)	PUNCT
cajgh-29	103	8	(	(	PUNCT
cajgh-29	103	9	1593a	1593a	NUM
cajgh-29	103	10	>	>	SYM
cajgh-29	103	11	g	g	NOUN
cajgh-29	103	12	)	)	PUNCT
cajgh-29	103	13	synonymous	synonymous	ADJ
cajgh-29	103	14	ser455ser	ser455ser	NOUN
cajgh-29	103	15	(	(	PUNCT
cajgh-29	103	16	s455s	s455s	PROPN
cajgh-29	103	17	)	)	PUNCT
cajgh-29	103	18	81(52.2	81(52.2	NOUN
cajgh-29	103	19	*	*	SYM
cajgh-29	103	20	)	)	PUNCT
cajgh-29	103	21	48(59.2)/	48(59.2)/	NOUN
cajgh-29	103	22	33(40.7	33(40.7	NOUN
cajgh-29	103	23	)	)	PUNCT
cajgh-29	103	24	#	#	NOUN
cajgh-29	103	25	48(42.8	48(42.8	NOUN
cajgh-29	103	26	)	)	PUNCT
cajgh-29	103	27	19(39.6)/	19(39.6)/	NOUN
cajgh-29	103	28	29(60.4	29(60.4	NUM
cajgh-29	103	29	)	)	PUNCT
cajgh-29	103	30	#	#	NOUN
cajgh-29	103	31	yes	yes	NOUN
cajgh-29	103	32	11	11	NUM
cajgh-29	103	33	c.2229(t	c.2229(t	NOUN
cajgh-29	103	34	>	>	X
cajgh-29	103	35	c	c	NOUN
cajgh-29	103	36	)	)	PUNCT
cajgh-29	103	37	(	(	PUNCT
cajgh-29	103	38	2457t	2457t	NUM
cajgh-29	103	39	>	>	SYM
cajgh-29	103	40	c	c	X
cajgh-29	103	41	)	)	PUNCT
cajgh-29	103	42	synonymous	synonymous	ADJ
cajgh-29	103	43	his473his	his473his	PROPN
cajgh-29	103	44	(	(	PUNCT
cajgh-29	103	45	h473h	h473h	PROPN
cajgh-29	103	46	)	)	PUNCT
cajgh-29	103	47	81(52.2	81(52.2	NUM
cajgh-29	103	48	)	)	PUNCT
cajgh-29	103	49	*	*	SYM
cajgh-29	103	50	48(59.2)/	48(59.2)/	NUM
cajgh-29	103	51	33(40.7	33(40.7	NOUN
cajgh-29	103	52	)	)	PUNCT
cajgh-29	103	53	#	#	NOUN
cajgh-29	103	54	48(42.8	48(42.8	NOUN
cajgh-29	103	55	)	)	PUNCT
cajgh-29	103	56	19(39.6)/	19(39.6)/	NOUN
cajgh-29	103	57	29(60.4	29(60.4	NUM
cajgh-29	103	58	)	)	PUNCT
cajgh-29	103	59	#	#	NOUN
cajgh-29	104	1	yes	yes	NOUN
cajgh-29	104	2	14	14	NUM
cajgh-29	104	3	c.7242(a	c.7242(a	PROPN
cajgh-29	104	4	>	>	X
cajgh-29	104	5	g	g	NOUN
cajgh-29	104	6	)	)	PUNCT
cajgh-29	104	7	(	(	PUNCT
cajgh-29	104	8	7470a	7470a	NUM
cajgh-29	104	9	>	>	SYM
cajgh-29	104	10	g	g	NOUN
cajgh-29	104	11	)	)	PUNCT
cajgh-29	104	12	synonymous	synonymous	ADJ
cajgh-29	104	13	ser2414ser	ser2414ser	PROPN
cajgh-29	104	14	(	(	PUNCT
cajgh-29	104	15	s2414s	s2414s	PROPN
cajgh-29	104	16	)	)	PUNCT
cajgh-29	104	17	61(39.0	61(39.0	NOUN
cajgh-29	104	18	)	)	PUNCT
cajgh-29	104	19	*	*	PUNCT
cajgh-29	105	1	35(57.3)/	35(57.3)/	NUM
cajgh-29	105	2	26(42.6	26(42.6	NUM
cajgh-29	105	3	)	)	PUNCT
cajgh-29	105	4	#	#	NOUN
cajgh-29	105	5	36(32.1	36(32.1	NOUN
cajgh-29	105	6	)	)	PUNCT
cajgh-29	105	7	16(44.4)/	16(44.4)/	NOUN
cajgh-29	105	8	20(55.5	20(55.5	NUM
cajgh-29	105	9	)	)	PUNCT
cajgh-29	106	1	yes	yes	CCONJ
cajgh-29	106	2	†	†	NOUN
cajgh-29	106	3	numbering	numbering	NOUN
cajgh-29	106	4	according	accord	VERB
cajgh-29	106	5	to	to	ADP
cajgh-29	106	6	genbank	genbank	PROPN
cajgh-29	106	7	accession	accession	NOUN
cajgh-29	107	1	no	no	PROPN
cajgh-29	107	2	.	.	PUNCT
cajgh-29	107	3	nm_000059.1	nm_000059.1	PROPN
cajgh-29	107	4	,	,	PUNCT
cajgh-29	107	5	the	the	DET
cajgh-29	107	6	a	a	NOUN
cajgh-29	107	7	of	of	ADP
cajgh-29	107	8	the	the	DET
cajgh-29	107	9	atg	atg	PROPN
cajgh-29	107	10	translation	translation	NOUN
cajgh-29	107	11	initiation	initiation	NOUN
cajgh-29	107	12	codon	codon	PROPN
cajgh-29	107	13	is	be	AUX
cajgh-29	107	14	+1	+1	PROPN
cajgh-29	107	15	,	,	PUNCT
cajgh-29	107	16	according	accord	VERB
cajgh-29	107	17	to	to	ADP
cajgh-29	107	18	approved	approve	VERB
cajgh-29	107	19	guidelines	guideline	NOUN
cajgh-29	107	20	(	(	PUNCT
cajgh-29	107	21	http://www.hgvs.org/mutnomen/	http://www.hgvs.org/mutnomen/	NOUN
cajgh-29	107	22	)	)	PUNCT
cajgh-29	107	23	.	.	PUNCT
cajgh-29	108	1	‡the	‡the	DET
cajgh-29	108	2	nomenclature	nomenclature	NOUN
cajgh-29	108	3	as	as	SCONJ
cajgh-29	108	4	used	use	VERB
cajgh-29	108	5	in	in	ADP
cajgh-29	108	6	the	the	DET
cajgh-29	108	7	bic	bic	PROPN
cajgh-29	108	8	database	database	NOUN
cajgh-29	108	9	is	be	AUX
cajgh-29	108	10	given	give	VERB
cajgh-29	108	11	in	in	ADP
cajgh-29	108	12	parentheses	parenthesis	NOUN
cajgh-29	108	13	.	.	PUNCT
cajgh-29	109	1	mutation	mutation	NOUN
cajgh-29	109	2	nomenclature	nomenclature	NOUN
cajgh-29	109	3	is	be	AUX
cajgh-29	109	4	according	accord	VERB
cajgh-29	109	5	to	to	ADP
cajgh-29	109	6	genbank	genbank	NOUN
cajgh-29	109	7	accession	accession	NOUN
cajgh-29	109	8	number	number	NOUN
cajgh-29	109	9	u43746	u43746	PROPN
cajgh-29	109	10	(	(	PUNCT
cajgh-29	109	11	brca2	brca2	PROPN
cajgh-29	109	12	)	)	PUNCT
cajgh-29	109	13	with	with	ADP
cajgh-29	109	14	numbering	numbering	NOUN
cajgh-29	109	15	starting	start	VERB
cajgh-29	109	16	at	at	ADP
cajgh-29	109	17	the	the	DET
cajgh-29	109	18	a	a	NOUN
cajgh-29	109	19	of	of	ADP
cajgh-29	109	20	the	the	DET
cajgh-29	109	21	first	first	ADJ
cajgh-29	109	22	atg	atg	NOUN
cajgh-29	109	23	at	at	ADP
cajgh-29	109	24	the	the	DET
cajgh-29	109	25	posotion	posotion	NOUN
cajgh-29	109	26	229	229	NUM
cajgh-29	109	27	.	.	PUNCT
cajgh-29	110	1	*	*	PUNCT
cajgh-29	110	2	p<0.05	p<0.05	PROPN
cajgh-29	110	3	,	,	PUNCT
cajgh-29	110	4	*	*	PUNCT
cajgh-29	110	5	*	*	PUNCT
cajgh-29	110	6	p<0.001	p<0.001	VERB
cajgh-29	110	7	between	between	ADP
cajgh-29	110	8	cases	case	NOUN
cajgh-29	110	9	and	and	CCONJ
cajgh-29	110	10	controls	control	VERB
cajgh-29	110	11	#	#	SYM
cajgh-29	110	12	p<0.05	p<0.05	NOUN
cajgh-29	110	13	,	,	PUNCT
cajgh-29	110	14	#	#	SYM
cajgh-29	110	15	#	#	NOUN
cajgh-29	110	16	-p<0.001	-p<0.001	NOUN
cajgh-29	110	17	between	between	ADP
cajgh-29	110	18	caucasians	caucasians	PROPN
cajgh-29	110	19	and	and	CCONJ
cajgh-29	110	20	asians	asians	PROPN
cajgh-29	110	21	in	in	ADP
cajgh-29	110	22	group	group	NOUN
cajgh-29	110	23	there	there	PRON
cajgh-29	110	24	was	be	VERB
cajgh-29	110	25	no	no	DET
cajgh-29	110	26	significant	significant	ADJ
cajgh-29	110	27	difference	difference	NOUN
cajgh-29	110	28	in	in	ADP
cajgh-29	110	29	frequency	frequency	NOUN
cajgh-29	110	30	of	of	ADP
cajgh-29	110	31	missense	missense	NOUN
cajgh-29	110	32	mutations	mutation	NOUN
cajgh-29	110	33	c.2350a	c.2350a	PROPN
cajgh-29	110	34	>	>	X
cajgh-29	110	35	g	g	PROPN
cajgh-29	110	36	(	(	PUNCT
cajgh-29	110	37	m784v	m784v	PROPN
cajgh-29	110	38	)	)	PUNCT
cajgh-29	110	39	,	,	PUNCT
cajgh-29	110	40	c.2410g	c.2410g	NOUN
cajgh-29	110	41	>	>	X
cajgh-29	110	42	a	a	DET
cajgh-29	110	43	(	(	PUNCT
cajgh-29	110	44	d804n	d804n	PROPN
cajgh-29	110	45	)	)	PUNCT
cajgh-29	110	46	,	,	PUNCT
cajgh-29	110	47	c.3422t	c.3422t	NOUN
cajgh-29	110	48	>	>	X
cajgh-29	110	49	c	c	X
cajgh-29	110	50	(	(	PUNCT
cajgh-29	110	51	i1141	i1141	PROPN
cajgh-29	110	52	t	t	PROPN
cajgh-29	110	53	)	)	PUNCT
cajgh-29	110	54	,	,	PUNCT
cajgh-29	110	55	c.3572c	c.3572c	PROPN
cajgh-29	110	56	>	>	X
cajgh-29	110	57	t	t	PROPN
cajgh-29	110	58	(	(	PUNCT
cajgh-29	110	59	s1191f	s1191f	NOUN
cajgh-29	110	60	)	)	PUNCT
cajgh-29	110	61	in	in	ADP
cajgh-29	110	62	cases	case	NOUN
cajgh-29	110	63	compared	compare	VERB
cajgh-29	110	64	to	to	ADP
cajgh-29	110	65	controls	control	NOUN
cajgh-29	110	66	.	.	PUNCT
cajgh-29	111	1	synonymous	synonymous	ADJ
cajgh-29	111	2	polymorphisms	polymorphism	NOUN
cajgh-29	111	3	s455s	s455s	PROPN
cajgh-29	111	4	,	,	PUNCT
cajgh-29	111	5	h473h	h473h	PROPN
cajgh-29	111	6	,	,	PUNCT
cajgh-29	111	7	were	be	AUX
cajgh-29	111	8	detected	detect	VERB
cajgh-29	111	9	in	in	ADP
cajgh-29	111	10	81	81	NUM
cajgh-29	111	11	(	(	PUNCT
cajgh-29	111	12	52.2	52.2	NUM
cajgh-29	111	13	%	%	NOUN
cajgh-29	111	14	)	)	PUNCT
cajgh-29	111	15	cases	case	NOUN
cajgh-29	111	16	and	and	CCONJ
cajgh-29	111	17	s2114s	s2114s	PROPN
cajgh-29	111	18	was	be	AUX
cajgh-29	111	19	detected	detect	VERB
cajgh-29	111	20	in	in	ADP
cajgh-29	111	21	61	61	NUM
cajgh-29	111	22	(	(	PUNCT
cajgh-29	111	23	39.0	39.0	NUM
cajgh-29	111	24	%	%	NOUN
cajgh-29	111	25	)	)	PUNCT
cajgh-29	111	26	cases	case	NOUN
cajgh-29	111	27	,	,	PUNCT
cajgh-29	111	28	p>0.05	p>0.05	NOUN
cajgh-29	111	29	(	(	PUNCT
cajgh-29	111	30	table	table	NOUN
cajgh-29	111	31	3	3	NUM
cajgh-29	111	32	)	)	PUNCT
cajgh-29	111	33	.	.	PUNCT
cajgh-29	112	1	all	all	DET
cajgh-29	112	2	identified	identify	VERB
cajgh-29	112	3	polymorphisms	polymorphism	NOUN
cajgh-29	112	4	were	be	AUX
cajgh-29	112	5	previously	previously	ADV
cajgh-29	112	6	reported	report	VERB
cajgh-29	112	7	in	in	ADP
cajgh-29	112	8	the	the	DET
cajgh-29	112	9	bic	bic	PROPN
cajgh-29	112	10	database26	database26	PROPN
cajgh-29	112	11	(	(	PUNCT
cajgh-29	112	12	table	table	NOUN
cajgh-29	112	13	2,3	2,3	NUM
cajgh-29	112	14	)	)	PUNCT
cajgh-29	112	15	.	.	PUNCT
cajgh-29	113	1	interestingly	interestingly	ADV
cajgh-29	113	2	,	,	PUNCT
cajgh-29	113	3	frequency	frequency	NOUN
cajgh-29	113	4	of	of	ADP
cajgh-29	113	5	nearly	nearly	ADV
cajgh-29	113	6	all	all	PRON
cajgh-29	113	7	sequence	sequence	NOUN
cajgh-29	113	8	variants	variant	NOUN
cajgh-29	113	9	was	be	AUX
cajgh-29	113	10	significantly	significantly	ADV
cajgh-29	113	11	different	different	ADJ
cajgh-29	113	12	in	in	ADP
cajgh-29	113	13	caucasian	caucasian	ADJ
cajgh-29	113	14	and	and	CCONJ
cajgh-29	113	15	asian	asian	ADJ
cajgh-29	113	16	groups	group	NOUN
cajgh-29	113	17	of	of	ADP
cajgh-29	113	18	study	study	NOUN
cajgh-29	113	19	participants	participant	NOUN
cajgh-29	113	20	(	(	PUNCT
cajgh-29	113	21	table	table	NOUN
cajgh-29	113	22	2,3	2,3	NUM
cajgh-29	113	23	)	)	PUNCT
cajgh-29	113	24	.	.	PUNCT
cajgh-29	114	1	there	there	PRON
cajgh-29	114	2	was	be	VERB
cajgh-29	114	3	higher	high	ADJ
cajgh-29	114	4	prevalence	prevalence	NOUN
cajgh-29	114	5	of	of	ADP
cajgh-29	114	6	observed	observed	ADJ
cajgh-29	114	7	mutations	mutation	NOUN
cajgh-29	114	8	in	in	ADP
cajgh-29	114	9	caucasian	caucasian	ADJ
cajgh-29	114	10	cases	case	NOUN
cajgh-29	114	11	comparing	compare	VERB
cajgh-29	114	12	to	to	ADP
cajgh-29	114	13	asian	asian	ADJ
cajgh-29	114	14	breast	breast	NOUN
cajgh-29	114	15	cancer	cancer	NOUN
cajgh-29	114	16	cases	case	NOUN
cajgh-29	114	17	(	(	PUNCT
cajgh-29	114	18	p<0.05	p<0.05	NOUN
cajgh-29	114	19	)	)	PUNCT
cajgh-29	114	20	and	and	CCONJ
cajgh-29	114	21	higher	high	ADJ
cajgh-29	114	22	frequency	frequency	NOUN
cajgh-29	114	23	of	of	ADP
cajgh-29	114	24	sequence	sequence	NOUN
cajgh-29	114	25	variants	variant	NOUN
cajgh-29	114	26	was	be	AUX
cajgh-29	114	27	observed	observe	VERB
cajgh-29	114	28	in	in	ADP
cajgh-29	114	29	the	the	DET
cajgh-29	114	30	control	control	NOUN
cajgh-29	114	31	group	group	NOUN
cajgh-29	114	32	in	in	ADP
cajgh-29	114	33	asians	asians	PROPN
cajgh-29	114	34	.	.	PUNCT
cajgh-29	115	1	the	the	DET
cajgh-29	115	2	clinical	clinical	ADJ
cajgh-29	115	3	and	and	CCONJ
cajgh-29	115	4	pathological	pathological	ADJ
cajgh-29	115	5	characteristics	characteristic	NOUN
cajgh-29	115	6	of	of	ADP
cajgh-29	115	7	women	woman	NOUN
cajgh-29	115	8	with	with	ADP
cajgh-29	115	9	breast	breast	NOUN
cajgh-29	115	10	cancer	cancer	NOUN
cajgh-29	115	11	are	be	AUX
cajgh-29	115	12	summarized	summarize	VERB
cajgh-29	115	13	in	in	ADP
cajgh-29	115	14	:	:	PUNCT
cajgh-29	115	15	table	table	NOUN
cajgh-29	115	16	4	4	NUM
cajgh-29	115	17	:	:	PUNCT
cajgh-29	115	18	clinical	clinical	ADJ
cajgh-29	115	19	-	-	PUNCT
cajgh-29	115	20	pathological	pathological	ADJ
cajgh-29	115	21	profile	profile	NOUN
cajgh-29	115	22	of	of	ADP
cajgh-29	115	23	breast	breast	NOUN
cajgh-29	115	24	cancer	cancer	NOUN
cajgh-29	115	25	cases	case	NOUN
cajgh-29	115	26	with	with	ADP
cajgh-29	115	27	/	/	SYM
cajgh-29	115	28	or	or	CCONJ
cajgh-29	115	29	without	without	ADP
cajgh-29	115	30	brca1/2	brca1/2	ADJ
cajgh-29	115	31	polymorphisms	polymorphism	NOUN
cajgh-29	115	32	cases	case	NOUN
cajgh-29	115	33	(	(	PUNCT
cajgh-29	115	34	n=156	n=156	NOUN
cajgh-29	115	35	)	)	PUNCT
cajgh-29	115	36	polymorphism	polymorphism	NOUN
cajgh-29	115	37	positive	positive	ADJ
cajgh-29	115	38	(	(	PUNCT
cajgh-29	115	39	n	n	NOUN
cajgh-29	115	40	=	=	SYM
cajgh-29	115	41	111	111	NUM
cajgh-29	115	42	)	)	PUNCT
cajgh-29	115	43	71.2	71.2	NUM
cajgh-29	115	44	%	%	NOUN
cajgh-29	115	45	polymorphism	polymorphism	NOUN
cajgh-29	115	46	negative	negative	ADJ
cajgh-29	115	47	(	(	PUNCT
cajgh-29	115	48	n	n	NOUN
cajgh-29	115	49	=	=	SYM
cajgh-29	115	50	45	45	NUM
cajgh-29	115	51	)	)	PUNCT
cajgh-29	115	52	28.8	28.8	NUM
cajgh-29	115	53	%	%	NOUN
cajgh-29	115	54	1	1	NUM
cajgh-29	115	55	polymorphism	polymorphism	NOUN
cajgh-29	115	56	15(13.6	15(13.6	NUM
cajgh-29	115	57	)	)	PUNCT
cajgh-29	115	58	2	2	NUM
cajgh-29	115	59	-	-	SYM
cajgh-29	115	60	3	3	NUM
cajgh-29	115	61	polymorphisms	polymorphism	NOUN
cajgh-29	115	62	17(15.2	17(15.2	NUM
cajgh-29	115	63	)	)	PUNCT
cajgh-29	115	64	4	4	NUM
cajgh-29	115	65	-	-	SYM
cajgh-29	115	66	6	6	NUM
cajgh-29	115	67	polymorphisms	polymorphism	NOUN
cajgh-29	115	68	79(71.2	79(71.2	NOUN
cajgh-29	115	69	)	)	PUNCT
cajgh-29	115	70	age	age	NOUN
cajgh-29	115	71	50.6±8.8	50.6±8.8	NUM
cajgh-29	116	1	52.7±10.7	52.7±10.7	NUM
cajgh-29	116	2	caucasian	caucasian	ADJ
cajgh-29	116	3	66(59.3	66(59.3	NOUN
cajgh-29	116	4	)	)	PUNCT
cajgh-29	116	5	28(62.5	28(62.5	NOUN
cajgh-29	116	6	)	)	PUNCT
cajgh-29	116	7	asian	asian	ADJ
cajgh-29	116	8	45(40.7	45(40.7	ADJ
cajgh-29	116	9	)	)	PUNCT
cajgh-29	116	10	17(37.5	17(37.5	NUM
cajgh-29	116	11	)	)	PUNCT
cajgh-29	116	12	tumor	tumor	NOUN
cajgh-29	116	13	histology	histology	NOUN
cajgh-29	116	14	invasive	invasive	ADJ
cajgh-29	116	15	ductal	ductal	ADJ
cajgh-29	116	16	68(61.0	68(61.0	NOUN
cajgh-29	116	17	)	)	PUNCT
cajgh-29	116	18	32(70.8	32(70.8	NUM
cajgh-29	116	19	)	)	PUNCT
cajgh-29	116	20	invasive	invasive	ADJ
cajgh-29	116	21	lobular	lobular	ADJ
cajgh-29	116	22	34(30.5	34(30.5	NUM
cajgh-29	116	23	)	)	PUNCT
cajgh-29	116	24	13(29.2	13(29.2	NUM
cajgh-29	116	25	)	)	PUNCT
cajgh-29	116	26	medullary	medullary	ADJ
cajgh-29	116	27	8(6.8	8(6.8	NUM
cajgh-29	116	28	)	)	PUNCT
cajgh-29	116	29	mucinous	mucinous	ADJ
cajgh-29	116	30	2(1.7	2(1.7	NUM
cajgh-29	116	31	)	)	PUNCT
cajgh-29	116	32	tumor	tumor	NOUN
cajgh-29	116	33	size	size	NOUN
cajgh-29	116	34	t1	t1	NOUN
cajgh-29	116	35	1(1.1	1(1.1	NUM
cajgh-29	116	36	)	)	PUNCT
cajgh-29	116	37	4(8.4	4(8.4	NUM
cajgh-29	116	38	)	)	PUNCT
cajgh-29	116	39	t2	t2	NOUN
cajgh-29	116	40	66(59.3	66(59.3	NOUN
cajgh-29	116	41	)	)	PUNCT
cajgh-29	116	42	30(66.7	30(66.7	NUM
cajgh-29	116	43	)	)	PUNCT
cajgh-29	116	44	30(27.1	30(27.1	NUM
cajgh-29	116	45	)	)	PUNCT
cajgh-29	116	46	9(20.8	9(20.8	NUM
cajgh-29	116	47	)	)	PUNCT
cajgh-29	116	48	t4	t4	PROPN
cajgh-29	116	49	38(3.4	38(3.4	NUM
cajgh-29	116	50	)	)	PUNCT
cajgh-29	116	51	2(4.2	2(4.2	NUM
cajgh-29	116	52	)	)	PUNCT
cajgh-29	116	53	lymph	lymph	NOUN
cajgh-29	116	54	node	node	NOUN
cajgh-29	116	55	involvement	involvement	NOUN
cajgh-29	116	56	yes	yes	INTJ
cajgh-29	116	57	21(18.6	21(18.6	NOUN
cajgh-29	116	58	)	)	PUNCT
cajgh-29	116	59	4(16.7	4(16.7	NUM
cajgh-29	116	60	)	)	PUNCT
cajgh-29	116	61	no	no	DET
cajgh-29	116	62	90(81.4	90(81.4	NOUN
cajgh-29	116	63	)	)	PUNCT
cajgh-29	116	64	20(83.3	20(83.3	NOUN
cajgh-29	116	65	)	)	PUNCT
cajgh-29	116	66	t	t	NOUN
cajgh-29	116	67	–	–	PUNCT
cajgh-29	116	68	primary	primary	ADJ
cajgh-29	116	69	tumor	tumor	NOUN
cajgh-29	116	70	:	:	PUNCT
cajgh-29	116	71	t1	t1	NOUN
cajgh-29	116	72	≤2	≤2	NOUN
cajgh-29	116	73	cm	cm	NOUN
cajgh-29	116	74	,	,	PUNCT
cajgh-29	116	75	t2	t2	NOUN
cajgh-29	116	76	–	–	PUNCT
cajgh-29	116	77	>	>	X
cajgh-29	116	78	2	2	NUM
cajgh-29	116	79	to	to	PART
cajgh-29	116	80	5	5	NUM
cajgh-29	116	81	cm	cm	NOUN
cajgh-29	116	82	,	,	PUNCT
cajgh-29	116	83	t3	t3	PROPN
cajgh-29	116	84	>	>	X
cajgh-29	116	85	5	5	NUM
cajgh-29	116	86	cm	cm	NOUN
cajgh-29	116	87	,	,	PUNCT
cajgh-29	116	88	t4	t4	PROPN
cajgh-29	116	89	–	–	PUNCT
cajgh-29	116	90	tumor	tumor	NOUN
cajgh-29	116	91	of	of	ADP
cajgh-29	116	92	any	any	DET
cajgh-29	116	93	size	size	NOUN
cajgh-29	116	94	with	with	ADP
cajgh-29	116	95	direct	direct	ADJ
cajgh-29	116	96	extension	extension	NOUN
cajgh-29	116	97	to	to	PART
cajgh-29	116	98	chest	chest	VERB
cajgh-29	116	99	wall	wall	NOUN
cajgh-29	116	100	or	or	CCONJ
cajgh-29	116	101	skin	skin	NOUN
cajgh-29	116	102	,	,	PUNCT
cajgh-29	116	103	n	n	CCONJ
cajgh-29	116	104	–	–	PUNCT
cajgh-29	116	105	regional	regional	ADJ
cajgh-29	116	106	lymph	lymph	NOUN
cajgh-29	116	107	nodes	node	NOUN
cajgh-29	116	108	,	,	PUNCT
cajgh-29	116	109	m	m	ADJ
cajgh-29	116	110	–	–	PUNCT
cajgh-29	116	111	distant	distant	ADJ
cajgh-29	116	112	metastasis	metastasis	NOUN
cajgh-29	116	113	there	there	PRON
cajgh-29	116	114	was	be	VERB
cajgh-29	116	115	no	no	DET
cajgh-29	116	116	significant	significant	ADJ
cajgh-29	116	117	difference	difference	NOUN
cajgh-29	116	118	between	between	ADP
cajgh-29	116	119	both	both	DET
cajgh-29	116	120	groups	group	NOUN
cajgh-29	116	121	of	of	ADP
cajgh-29	116	122	cases	case	NOUN
cajgh-29	116	123	in	in	ADP
cajgh-29	116	124	mean	mean	NOUN
cajgh-29	116	125	age	age	NOUN
cajgh-29	116	126	at	at	ADP
cajgh-29	116	127	diagnosis	diagnosis	NOUN
cajgh-29	116	128	(	(	PUNCT
cajgh-29	116	129	50.6±8.8	50.6±8.8	NUM
cajgh-29	116	130	years	year	NOUN
cajgh-29	116	131	vs.	vs.	ADP
cajgh-29	116	132	52.7±10.7	52.7±10.7	NUM
cajgh-29	116	133	years	year	NOUN
cajgh-29	116	134	,	,	PUNCT
cajgh-29	116	135	respectively	respectively	ADV
cajgh-29	116	136	,	,	PUNCT
cajgh-29	116	137	p=0.36	p=0.36	NOUN
cajgh-29	116	138	)	)	PUNCT
cajgh-29	116	139	.	.	PUNCT
cajgh-29	117	1	assuming	assume	VERB
cajgh-29	117	2	that	that	SCONJ
cajgh-29	117	3	the	the	DET
cajgh-29	117	4	absolute	absolute	ADJ
cajgh-29	117	5	numbers	number	NOUN
cajgh-29	117	6	of	of	ADP
cajgh-29	117	7	co	co	ADJ
cajgh-29	117	8	-	-	ADJ
cajgh-29	117	9	existing	exist	VERB
cajgh-29	117	10	brca1/2	brca1/2	ADJ
cajgh-29	117	11	alterations	alteration	NOUN
cajgh-29	117	12	in	in	ADP
cajgh-29	117	13	each	each	DET
cajgh-29	117	14	case	case	NOUN
cajgh-29	117	15	may	may	AUX
cajgh-29	117	16	also	also	ADV
cajgh-29	117	17	play	play	VERB
cajgh-29	117	18	a	a	DET
cajgh-29	117	19	relevant	relevant	ADJ
cajgh-29	117	20	biological	biological	ADJ
cajgh-29	117	21	role	role	NOUN
cajgh-29	117	22	,	,	PUNCT
cajgh-29	117	23	the	the	DET
cajgh-29	117	24	cases	case	NOUN
cajgh-29	117	25	in	in	ADP
cajgh-29	117	26	the	the	DET
cajgh-29	117	27	mutation	mutation	NOUN
cajgh-29	117	28	-	-	PUNCT
cajgh-29	117	29	positive	positive	ADJ
cajgh-29	117	30	group	group	NOUN
cajgh-29	117	31	were	be	AUX
cajgh-29	117	32	divided	divide	VERB
cajgh-29	117	33	in	in	ADP
cajgh-29	117	34	three	three	NUM
cajgh-29	117	35	subgroups	subgroup	NOUN
cajgh-29	117	36	:	:	PUNCT
cajgh-29	117	37	(	(	PUNCT
cajgh-29	117	38	a	a	X
cajgh-29	117	39	)	)	PUNCT
cajgh-29	117	40	with	with	ADP
cajgh-29	117	41	1	1	NUM
cajgh-29	117	42	alteration	alteration	NOUN
cajgh-29	117	43	;	;	PUNCT
cajgh-29	117	44	(	(	PUNCT
cajgh-29	117	45	b	b	X
cajgh-29	117	46	)	)	PUNCT
cajgh-29	117	47	with	with	ADP
cajgh-29	117	48	2	2	NUM
cajgh-29	117	49	-	-	SYM
cajgh-29	117	50	3	3	NUM
cajgh-29	117	51	alterations	alteration	NOUN
cajgh-29	117	52	;	;	PUNCT
cajgh-29	117	53	(	(	PUNCT
cajgh-29	117	54	c	c	X
cajgh-29	117	55	)	)	PUNCT
cajgh-29	117	56	with	with	ADP
cajgh-29	117	57	4	4	NUM
cajgh-29	117	58	-	-	SYM
cajgh-29	117	59	6	6	NUM
cajgh-29	117	60	alterations	alteration	NOUN
cajgh-29	117	61	.	.	PUNCT
cajgh-29	118	1	we	we	PRON
cajgh-29	118	2	found	find	VERB
cajgh-29	118	3	that	that	SCONJ
cajgh-29	118	4	79	79	NUM
cajgh-29	118	5	of	of	ADP
cajgh-29	118	6	156	156	NUM
cajgh-29	118	7	women	woman	NOUN
cajgh-29	118	8	(	(	PUNCT
cajgh-29	118	9	71.2	71.2	NUM
cajgh-29	118	10	%	%	NOUN
cajgh-29	118	11	)	)	PUNCT
cajgh-29	118	12	carried	carry	VERB
cajgh-29	118	13	4	4	NUM
cajgh-29	118	14	-	-	SYM
cajgh-29	118	15	6	6	NUM
cajgh-29	118	16	alterations	alteration	NOUN
cajgh-29	118	17	.	.	PUNCT
cajgh-29	119	1	this	this	PRON
cajgh-29	119	2	may	may	AUX
cajgh-29	119	3	be	be	AUX
cajgh-29	119	4	due	due	ADJ
cajgh-29	119	5	to	to	ADP
cajgh-29	119	6	polymorphisms	polymorphism	NOUN
cajgh-29	119	7	located	locate	VERB
cajgh-29	119	8	in	in	ADP
cajgh-29	119	9	one	one	NUM
cajgh-29	119	10	haplogroup	haplogroup	NOUN
cajgh-29	119	11	and	and	CCONJ
cajgh-29	119	12	inherited	inherit	VERB
cajgh-29	119	13	together	together	ADV
cajgh-29	119	14	.	.	PUNCT
cajgh-29	120	1	also	also	ADV
cajgh-29	120	2	amongst	amongst	ADP
cajgh-29	120	3	controls	control	NOUN
cajgh-29	120	4	,	,	PUNCT
cajgh-29	120	5	in	in	ADP
cajgh-29	120	6	48	48	NUM
cajgh-29	120	7	(	(	PUNCT
cajgh-29	120	8	73.8	73.8	NUM
cajgh-29	120	9	%	%	NOUN
cajgh-29	120	10	)	)	PUNCT
cajgh-29	120	11	of	of	ADP
cajgh-29	120	12	65	65	NUM
cajgh-29	120	13	alteration	alteration	NOUN
cajgh-29	120	14	carriers	carrier	NOUN
cajgh-29	120	15	we	we	PRON
cajgh-29	120	16	detected	detect	VERB
cajgh-29	120	17	more	more	ADJ
cajgh-29	120	18	than	than	ADP
cajgh-29	120	19	3	3	NUM
cajgh-29	120	20	mutations	mutation	NOUN
cajgh-29	120	21	simultaneously	simultaneously	ADV
cajgh-29	120	22	(	(	PUNCT
cajgh-29	120	23	data	datum	NOUN
cajgh-29	120	24	not	not	PART
cajgh-29	120	25	shown	show	VERB
cajgh-29	120	26	)	)	PUNCT
cajgh-29	120	27	.	.	PUNCT
cajgh-29	121	1	invasive	invasive	ADJ
cajgh-29	121	2	ductal	ductal	ADJ
cajgh-29	121	3	carcinoma	carcinoma	NOUN
cajgh-29	121	4	was	be	AUX
cajgh-29	121	5	the	the	DET
cajgh-29	121	6	predominant	predominant	ADJ
cajgh-29	121	7	histological	histological	ADJ
cajgh-29	121	8	subtype	subtype	NOUN
cajgh-29	121	9	in	in	ADP
cajgh-29	121	10	both	both	DET
cajgh-29	121	11	groups	group	NOUN
cajgh-29	121	12	(	(	PUNCT
cajgh-29	121	13	61.0	61.0	NUM
cajgh-29	121	14	%	%	NOUN
cajgh-29	121	15	and	and	CCONJ
cajgh-29	121	16	70.8	70.8	NUM
cajgh-29	121	17	%	%	NOUN
cajgh-29	121	18	,	,	PUNCT
cajgh-29	121	19	respectively	respectively	ADV
cajgh-29	121	20	)	)	PUNCT
cajgh-29	121	21	.	.	PUNCT
cajgh-29	122	1	primary	primary	ADJ
cajgh-29	122	2	tumors	tumor	NOUN
cajgh-29	122	3	larger	large	ADJ
cajgh-29	122	4	than	than	SCONJ
cajgh-29	122	5	5.0	5.0	NUM
cajgh-29	122	6	cm	cm	NOUN
cajgh-29	122	7	were	be	AUX
cajgh-29	122	8	more	more	ADV
cajgh-29	122	9	frequently	frequently	ADV
cajgh-29	122	10	found	find	VERB
cajgh-29	122	11	in	in	ADP
cajgh-29	122	12	women	woman	NOUN
cajgh-29	122	13	carrying	carry	VERB
cajgh-29	122	14	sequence	sequence	NOUN
cajgh-29	122	15	alterations	alteration	NOUN
cajgh-29	122	16	.	.	PUNCT
cajgh-29	123	1	however	however	ADV
cajgh-29	123	2	,	,	PUNCT
cajgh-29	123	3	the	the	DET
cajgh-29	123	4	size	size	NOUN
cajgh-29	123	5	of	of	ADP
cajgh-29	123	6	tumor	tumor	NOUN
cajgh-29	123	7	(	(	PUNCT
cajgh-29	123	8	t	t	NOUN
cajgh-29	123	9	stage	stage	NOUN
cajgh-29	123	10	)	)	PUNCT
cajgh-29	123	11	and	and	CCONJ
cajgh-29	123	12	lymph	lymph	NOUN
cajgh-29	123	13	node	node	PROPN
cajgh-29	123	14	involvement	involvement	NOUN
cajgh-29	123	15	did	do	AUX
cajgh-29	123	16	not	not	PART
cajgh-29	123	17	show	show	VERB
cajgh-29	123	18	a	a	DET
cajgh-29	123	19	statistically	statistically	ADV
cajgh-29	123	20	significant	significant	ADJ
cajgh-29	123	21	difference	difference	NOUN
cajgh-29	123	22	between	between	ADP
cajgh-29	123	23	these	these	DET
cajgh-29	123	24	two	two	NUM
cajgh-29	123	25	groups	group	NOUN
cajgh-29	123	26	(	(	PUNCT
cajgh-29	123	27	p=0.92	p=0.92	NOUN
cajgh-29	123	28	and	and	CCONJ
cajgh-29	123	29	p=1.0	p=1.0	NOUN
cajgh-29	123	30	,	,	PUNCT
cajgh-29	123	31	respectively	respectively	ADV
cajgh-29	123	32	)	)	PUNCT
cajgh-29	123	33	.	.	PUNCT
cajgh-29	124	1	discussion	discussion	NOUN
cajgh-29	124	2	156	156	NUM
cajgh-29	124	3	kazakhstan	kazakhstan	PROPN
cajgh-29	124	4	patients	patient	NOUN
cajgh-29	124	5	with	with	ADP
cajgh-29	124	6	sporadic	sporadic	ADJ
cajgh-29	124	7	breast	breast	NOUN
cajgh-29	124	8	cancer	cancer	NOUN
cajgh-29	124	9	were	be	AUX
cajgh-29	124	10	analyzed	analyze	VERB
cajgh-29	124	11	for	for	ADP
cajgh-29	124	12	mutations	mutation	NOUN
cajgh-29	124	13	throughout	throughout	ADP
cajgh-29	124	14	the	the	DET
cajgh-29	124	15	entire	entire	ADJ
cajgh-29	124	16	coding	code	VERB
cajgh-29	124	17	regions	region	NOUN
cajgh-29	124	18	of	of	ADP
cajgh-29	124	19	the	the	DET
cajgh-29	124	20	brca1	brca1	NOUN
cajgh-29	124	21	and	and	CCONJ
cajgh-29	124	22	brca2	brca2	NOUN
cajgh-29	124	23	genes	gene	NOUN
cajgh-29	124	24	,	,	PUNCT
cajgh-29	124	25	using	use	VERB
cajgh-29	124	26	direct	direct	ADJ
cajgh-29	124	27	sequencing	sequencing	NOUN
cajgh-29	124	28	.	.	PUNCT
cajgh-29	125	1	whereas	whereas	SCONJ
cajgh-29	125	2	the	the	DET
cajgh-29	125	3	majority	majority	NOUN
cajgh-29	125	4	of	of	ADP
cajgh-29	125	5	studies	study	NOUN
cajgh-29	125	6	on	on	ADP
cajgh-29	125	7	brca	brca	PROPN
cajgh-29	125	8	gene	gene	NOUN
cajgh-29	125	9	mutations	mutation	NOUN
cajgh-29	125	10	have	have	AUX
cajgh-29	125	11	focused	focus	VERB
cajgh-29	125	12	on	on	ADP
cajgh-29	125	13	western	western	ADJ
cajgh-29	125	14	populations	population	NOUN
cajgh-29	125	15	with	with	ADP
cajgh-29	125	16	a	a	DET
cajgh-29	125	17	family	family	NOUN
cajgh-29	125	18	history	history	NOUN
cajgh-29	125	19	of	of	ADP
cajgh-29	125	20	breast	breast	NOUN
cajgh-29	125	21	or	or	CCONJ
cajgh-29	125	22	ovarian	ovarian	ADJ
cajgh-29	125	23	cancer	cancer	NOUN
cajgh-29	125	24	,	,	PUNCT
cajgh-29	125	25	only	only	ADV
cajgh-29	125	26	a	a	DET
cajgh-29	125	27	relatively	relatively	ADV
cajgh-29	125	28	small	small	ADJ
cajgh-29	125	29	number	number	NOUN
cajgh-29	125	30	of	of	ADP
cajgh-29	125	31	investigations	investigation	NOUN
cajgh-29	125	32	on	on	ADP
cajgh-29	125	33	the	the	DET
cajgh-29	125	34	role	role	NOUN
cajgh-29	125	35	of	of	ADP
cajgh-29	125	36	the	the	DET
cajgh-29	125	37	brca	brca	PROPN
cajgh-29	125	38	genes	gene	NOUN
cajgh-29	125	39	have	have	AUX
cajgh-29	125	40	been	be	AUX
cajgh-29	125	41	undertaken	undertake	VERB
cajgh-29	125	42	in	in	ADP
cajgh-29	125	43	asian	asian	ADJ
cajgh-29	125	44	sporadic	sporadic	ADJ
cajgh-29	125	45	breast	breast	NOUN
cajgh-29	125	46	cancer	cancer	NOUN
cajgh-29	125	47	populations	population	NOUN
cajgh-29	125	48	.	.	PUNCT
cajgh-29	126	1	a	a	DET
cajgh-29	126	2	large	large	ADJ
cajgh-29	126	3	number	number	NOUN
cajgh-29	126	4	of	of	ADP
cajgh-29	126	5	distinct	distinct	ADJ
cajgh-29	126	6	mutations	mutation	NOUN
cajgh-29	126	7	in	in	ADP
cajgh-29	126	8	the	the	DET
cajgh-29	126	9	brca1	brca1	NOUN
cajgh-29	126	10	and	and	CCONJ
cajgh-29	126	11	brca2	brca2	NOUN
cajgh-29	126	12	genes	gene	NOUN
cajgh-29	126	13	have	have	AUX
cajgh-29	126	14	been	be	AUX
cajgh-29	126	15	reported	report	VERB
cajgh-29	126	16	worldwide	worldwide	ADV
cajgh-29	126	17	,	,	PUNCT
cajgh-29	126	18	but	but	CCONJ
cajgh-29	126	19	little	little	ADJ
cajgh-29	126	20	is	be	AUX
cajgh-29	126	21	known	know	VERB
cajgh-29	126	22	regarding	regard	VERB
cajgh-29	126	23	the	the	DET
cajgh-29	126	24	role	role	NOUN
cajgh-29	126	25	of	of	ADP
cajgh-29	126	26	these	these	DET
cajgh-29	126	27	inherited	inherit	VERB
cajgh-29	126	28	susceptibility	susceptibility	NOUN
cajgh-29	126	29	genes	gene	NOUN
cajgh-29	126	30	in	in	ADP
cajgh-29	126	31	breast	breast	NOUN
cajgh-29	126	32	cancer	cancer	NOUN
cajgh-29	126	33	risk	risk	NOUN
cajgh-29	126	34	among	among	ADP
cajgh-29	126	35	kazakhstan	kazakhstan	PROPN
cajgh-29	126	36	women	woman	NOUN
cajgh-29	126	37	.	.	PUNCT
cajgh-29	127	1	so	so	ADV
cajgh-29	127	2	far	far	ADV
cajgh-29	127	3	there	there	PRON
cajgh-29	127	4	was	be	VERB
cajgh-29	127	5	no	no	DET
cajgh-29	127	6	information	information	NOUN
cajgh-29	127	7	about	about	ADP
cajgh-29	127	8	the	the	DET
cajgh-29	127	9	role	role	NOUN
cajgh-29	127	10	of	of	ADP
cajgh-29	127	11	the	the	DET
cajgh-29	127	12	brca1/2	brca1/2	ADJ
cajgh-29	127	13	gene	gene	NOUN
cajgh-29	127	14	in	in	ADP
cajgh-29	127	15	breast	breast	NOUN
cajgh-29	127	16	cancer	cancer	NOUN
cajgh-29	127	17	risk	risk	NOUN
cajgh-29	127	18	among	among	ADP
cajgh-29	127	19	kazakhstan	kazakhstan	PROPN
cajgh-29	127	20	women	woman	NOUN
cajgh-29	127	21	.	.	PUNCT
cajgh-29	128	1	the	the	DET
cajgh-29	128	2	incidence	incidence	NOUN
cajgh-29	128	3	of	of	ADP
cajgh-29	128	4	detectable	detectable	ADJ
cajgh-29	128	5	brca1	brca1	NOUN
cajgh-29	128	6	sequence	sequence	NOUN
cajgh-29	128	7	alterations	alteration	NOUN
cajgh-29	128	8	was	be	AUX
cajgh-29	128	9	estimated	estimate	VERB
cajgh-29	128	10	for	for	ADP
cajgh-29	128	11	the	the	DET
cajgh-29	128	12	first	first	ADJ
cajgh-29	128	13	time	time	NOUN
cajgh-29	128	14	in	in	ADP
cajgh-29	128	15	females	female	NOUN
cajgh-29	128	16	with	with	ADP
cajgh-29	128	17	sporadic	sporadic	ADJ
cajgh-29	128	18	breast	breast	NOUN
cajgh-29	128	19	cancer	cancer	NOUN
cajgh-29	128	20	as	as	ADV
cajgh-29	128	21	well	well	ADV
cajgh-29	128	22	as	as	ADP
cajgh-29	128	23	in	in	ADP
cajgh-29	128	24	healthy	healthy	ADJ
cajgh-29	128	25	women	woman	NOUN
cajgh-29	128	26	from	from	ADP
cajgh-29	128	27	semipalatinsk	semipalatinsk	ADJ
cajgh-29	128	28	(	(	PUNCT
cajgh-29	128	29	east	east	PROPN
cajgh-29	128	30	kazakhstan	kazakhstan	PROPN
cajgh-29	128	31	)	)	PUNCT
cajgh-29	128	32	region	region	NOUN
cajgh-29	128	33	of	of	ADP
cajgh-29	128	34	kazakhstan	kazakhstan	PROPN
cajgh-29	128	35	in	in	ADP
cajgh-29	128	36	our	our	PRON
cajgh-29	128	37	studies	study	NOUN
cajgh-29	128	38	for	for	ADP
cajgh-29	128	39	the	the	DET
cajgh-29	128	40	first	first	ADJ
cajgh-29	128	41	time	time	NOUN
cajgh-29	128	42	beginning	begin	VERB
cajgh-29	128	43	from	from	ADP
cajgh-29	128	44	2006.46	2006.46	NUM
cajgh-29	128	45	we	we	PRON
cajgh-29	128	46	showed	show	VERB
cajgh-29	128	47	a	a	DET
cajgh-29	128	48	higher	high	ADJ
cajgh-29	128	49	prevalence	prevalence	NOUN
cajgh-29	128	50	of	of	ADP
cajgh-29	128	51	brca1	brca1	PROPN
cajgh-29	128	52	sequence	sequence	NOUN
cajgh-29	128	53	alterations	alteration	NOUN
cajgh-29	128	54	in	in	ADP
cajgh-29	128	55	exon	exon	NOUN
cajgh-29	128	56	11	11	NUM
cajgh-29	128	57	in	in	ADP
cajgh-29	128	58	59	59	NUM
cajgh-29	128	59	(	(	PUNCT
cajgh-29	128	60	71.1	71.1	NUM
cajgh-29	128	61	%	%	NOUN
cajgh-29	128	62	)	)	PUNCT
cajgh-29	128	63	from	from	ADP
cajgh-29	128	64	83	83	NUM
cajgh-29	128	65	women	woman	NOUN
cajgh-29	128	66	with	with	ADP
cajgh-29	128	67	breast	breast	NOUN
cajgh-29	128	68	cancer	cancer	NOUN
cajgh-29	128	69	and	and	CCONJ
cajgh-29	128	70	in	in	ADP
cajgh-29	128	71	65	65	NUM
cajgh-29	128	72	(	(	PUNCT
cajgh-29	128	73	58.0	58.0	NUM
cajgh-29	128	74	%	%	NOUN
cajgh-29	128	75	)	)	PUNCT
cajgh-29	128	76	from	from	ADP
cajgh-29	128	77	112	112	NUM
cajgh-29	128	78	healthy	healthy	ADJ
cajgh-29	128	79	women	woman	NOUN
cajgh-29	128	80	(	(	PUNCT
cajgh-29	128	81	controls	control	NOUN
cajgh-29	128	82	)	)	PUNCT
cajgh-29	128	83	.	.	PUNCT
cajgh-29	129	1	in	in	ADP
cajgh-29	129	2	the	the	DET
cajgh-29	129	3	present	present	ADJ
cajgh-29	129	4	study	study	NOUN
cajgh-29	129	5	,	,	PUNCT
cajgh-29	129	6	the	the	DET
cajgh-29	129	7	entire	entire	ADJ
cajgh-29	129	8	coding	code	VERB
cajgh-29	129	9	regions	region	NOUN
cajgh-29	129	10	of	of	ADP
cajgh-29	129	11	brca1	brca1	PROPN
cajgh-29	129	12	and	and	CCONJ
cajgh-29	129	13	brca2	brca2	PROPN
cajgh-29	129	14	were	be	AUX
cajgh-29	129	15	analyzed	analyze	VERB
cajgh-29	129	16	,	,	PUNCT
cajgh-29	129	17	and	and	CCONJ
cajgh-29	129	18	patients	patient	NOUN
cajgh-29	129	19	with	with	ADP
cajgh-29	129	20	sporadic	sporadic	ADJ
cajgh-29	129	21	breast	breast	NOUN
cajgh-29	129	22	cancer	cancer	NOUN
cajgh-29	129	23	were	be	AUX
cajgh-29	129	24	selected	select	VERB
cajgh-29	129	25	by	by	ADP
cajgh-29	129	26	excluding	exclude	VERB
cajgh-29	129	27	patients	patient	NOUN
cajgh-29	129	28	at	at	ADP
cajgh-29	129	29	high	high	ADJ
cajgh-29	129	30	risk	risk	NOUN
cajgh-29	129	31	of	of	ADP
cajgh-29	129	32	being	be	AUX
cajgh-29	129	33	mutation	mutation	NOUN
cajgh-29	129	34	-	-	PUNCT
cajgh-29	129	35	carriers	carrier	NOUN
cajgh-29	129	36	.	.	PUNCT
cajgh-29	130	1	this	this	PRON
cajgh-29	130	2	included	include	VERB
cajgh-29	130	3	those	those	PRON
cajgh-29	130	4	with	with	ADP
cajgh-29	130	5	a	a	DET
cajgh-29	130	6	family	family	NOUN
cajgh-29	130	7	history	history	NOUN
cajgh-29	130	8	of	of	ADP
cajgh-29	130	9	breast	breast	NOUN
cajgh-29	130	10	or	or	CCONJ
cajgh-29	130	11	ovarian	ovarian	ADJ
cajgh-29	130	12	cancer	cancer	NOUN
cajgh-29	130	13	,	,	PUNCT
cajgh-29	130	14	those	those	PRON
cajgh-29	130	15	diagnosed	diagnose	VERB
cajgh-29	130	16	at	at	ADP
cajgh-29	130	17	less	less	ADJ
cajgh-29	130	18	than	than	ADP
cajgh-29	130	19	35	35	NUM
cajgh-29	130	20	years	year	NOUN
cajgh-29	130	21	of	of	ADP
cajgh-29	130	22	age	age	NOUN
cajgh-29	130	23	,	,	PUNCT
cajgh-29	130	24	and	and	CCONJ
cajgh-29	130	25	those	those	PRON
cajgh-29	130	26	with	with	ADP
cajgh-29	130	27	bilateral	bilateral	ADJ
cajgh-29	130	28	or	or	CCONJ
cajgh-29	130	29	multifocal	multifocal	ADJ
cajgh-29	130	30	breast	breast	NOUN
cajgh-29	130	31	cancer	cancer	NOUN
cajgh-29	130	32	.	.	PUNCT
cajgh-29	131	1	given	give	VERB
cajgh-29	131	2	that	that	SCONJ
cajgh-29	131	3	the	the	DET
cajgh-29	131	4	great	great	ADJ
cajgh-29	131	5	majority	majority	NOUN
cajgh-29	131	6	of	of	ADP
cajgh-29	131	7	breast	breast	NOUN
cajgh-29	131	8	cancer	cancer	NOUN
cajgh-29	131	9	cases	case	NOUN
cajgh-29	131	10	are	be	AUX
cajgh-29	131	11	sporadic	sporadic	ADJ
cajgh-29	131	12	,	,	PUNCT
cajgh-29	131	13	further	further	ADJ
cajgh-29	131	14	extensive	extensive	ADJ
cajgh-29	131	15	studies	study	NOUN
cajgh-29	131	16	are	be	AUX
cajgh-29	131	17	needed	need	VERB
cajgh-29	131	18	to	to	PART
cajgh-29	131	19	precisely	precisely	ADV
cajgh-29	131	20	identify	identify	VERB
cajgh-29	131	21	the	the	DET
cajgh-29	131	22	roles	role	NOUN
cajgh-29	131	23	of	of	ADP
cajgh-29	131	24	brca	brca	PROPN
cajgh-29	131	25	genes	gene	NOUN
cajgh-29	131	26	in	in	ADP
cajgh-29	131	27	sporadic	sporadic	ADJ
cajgh-29	131	28	breast	breast	NOUN
cajgh-29	131	29	cancer	cancer	NOUN
cajgh-29	131	30	.	.	PUNCT
cajgh-29	132	1	in	in	ADP
cajgh-29	132	2	our	our	PRON
cajgh-29	132	3	present	present	ADJ
cajgh-29	132	4	study	study	NOUN
cajgh-29	132	5	we	we	PRON
cajgh-29	132	6	sequenced	sequence	VERB
cajgh-29	132	7	all	all	DET
cajgh-29	132	8	coding	code	VERB
cajgh-29	132	9	regions	region	NOUN
cajgh-29	132	10	of	of	ADP
cajgh-29	132	11	both	both	DET
cajgh-29	132	12	brca1	brca1	PROPN
cajgh-29	132	13	and	and	CCONJ
cajgh-29	132	14	brca2	brca2	NOUN
cajgh-29	132	15	genes	gene	NOUN
cajgh-29	132	16	in	in	ADP
cajgh-29	132	17	larger	large	ADJ
cajgh-29	132	18	group	group	NOUN
cajgh-29	132	19	of	of	ADP
cajgh-29	132	20	cases	case	NOUN
cajgh-29	132	21	including	include	VERB
cajgh-29	132	22	an	an	DET
cajgh-29	132	23	astana	astana	NOUN
cajgh-29	132	24	cohort	cohort	NOUN
cajgh-29	132	25	,	,	PUNCT
cajgh-29	132	26	where	where	SCONJ
cajgh-29	132	27	women	woman	NOUN
cajgh-29	132	28	gathered	gather	VERB
cajgh-29	132	29	from	from	ADP
cajgh-29	132	30	different	different	ADJ
cajgh-29	132	31	kazakhstan	kazakhstan	ADJ
cajgh-29	132	32	regions	region	NOUN
cajgh-29	132	33	.	.	PUNCT
cajgh-29	133	1	the	the	DET
cajgh-29	133	2	sequence	sequence	NOUN
cajgh-29	133	3	variants	variant	NOUN
cajgh-29	133	4	identified	identify	VERB
cajgh-29	133	5	in	in	ADP
cajgh-29	133	6	the	the	DET
cajgh-29	133	7	brca1/2	brca1/2	ADJ
cajgh-29	133	8	genes	gene	NOUN
cajgh-29	133	9	include	include	VERB
cajgh-29	133	10	16	16	NUM
cajgh-29	133	11	missense	missense	NOUN
cajgh-29	133	12	mutations	mutation	NOUN
cajgh-29	133	13	of	of	ADP
cajgh-29	133	14	unknown	unknown	ADJ
cajgh-29	133	15	clinical	clinical	ADJ
cajgh-29	133	16	significance	significance	NOUN
cajgh-29	133	17	and	and	CCONJ
cajgh-29	133	18	6	6	NUM
cajgh-29	133	19	synonymous	synonymous	ADJ
cajgh-29	133	20	polymorphisms	polymorphism	NOUN
cajgh-29	133	21	by	by	ADP
cajgh-29	133	22	mutation	mutation	NOUN
cajgh-29	133	23	type	type	NOUN
cajgh-29	133	24	(	(	PUNCT
cajgh-29	133	25	table	table	NOUN
cajgh-29	133	26	2	2	NUM
cajgh-29	133	27	,	,	PUNCT
cajgh-29	133	28	3	3	NUM
cajgh-29	133	29	and	and	CCONJ
cajgh-29	133	30	figure	figure	VERB
cajgh-29	133	31	1	1	NUM
cajgh-29	133	32	)	)	PUNCT
cajgh-29	133	33	.	.	PUNCT
cajgh-29	134	1	all	all	DET
cajgh-29	134	2	cases	case	NOUN
cajgh-29	134	3	of	of	ADP
cajgh-29	134	4	the	the	DET
cajgh-29	134	5	single	single	ADJ
cajgh-29	134	6	nucleotide	nucleotide	NOUN
cajgh-29	134	7	changes	change	NOUN
cajgh-29	134	8	in	in	ADP
cajgh-29	134	9	brca1	brca1	PROPN
cajgh-29	134	10	and	and	CCONJ
cajgh-29	134	11	brca2	brca2	PROPN
cajgh-29	134	12	detected	detect	VERB
cajgh-29	134	13	in	in	ADP
cajgh-29	134	14	the	the	DET
cajgh-29	134	15	study	study	NOUN
cajgh-29	134	16	were	be	AUX
cajgh-29	134	17	recorded	record	VERB
cajgh-29	134	18	according	accord	VERB
cajgh-29	134	19	to	to	ADP
cajgh-29	134	20	the	the	DET
cajgh-29	134	21	breast	breast	NOUN
cajgh-29	134	22	cancer	cancer	NOUN
cajgh-29	134	23	information	information	NOUN
cajgh-29	134	24	core.26	core.26	ADJ
cajgh-29	134	25	it	it	PRON
cajgh-29	134	26	seems	seem	VERB
cajgh-29	134	27	likely	likely	ADJ
cajgh-29	134	28	that	that	SCONJ
cajgh-29	134	29	five	five	NUM
cajgh-29	134	30	mutations	mutation	NOUN
cajgh-29	134	31	in	in	ADP
cajgh-29	134	32	brca1	brca1	PROPN
cajgh-29	134	33	(	(	PUNCT
cajgh-29	134	34	c.95g	c.95g	PROPN
cajgh-29	134	35	>	>	X
cajgh-29	134	36	t	t	PROPN
cajgh-29	134	37	,	,	PUNCT
cajgh-29	134	38	c.254	c.254	X
cajgh-29	134	39	a	a	DET
cajgh-29	134	40	>	>	X
cajgh-29	134	41	g	g	NOUN
cajgh-29	134	42	,	,	PUNCT
cajgh-29	134	43	c.2612c	c.2612c	NOUN
cajgh-29	134	44	>	>	X
cajgh-29	134	45	t	t	PROPN
cajgh-29	134	46	,	,	PUNCT
cajgh-29	134	47	c.3113a	c.3113a	NOUN
cajgh-29	134	48	>	>	X
cajgh-29	134	49	g	g	NOUN
cajgh-29	134	50	,	,	PUNCT
cajgh-29	134	51	c.3348a	c.3348a	X
cajgh-29	134	52	>	>	NOUN
cajgh-29	134	53	g	g	NOUN
cajgh-29	134	54	)	)	PUNCT
cajgh-29	134	55	and	and	CCONJ
cajgh-29	134	56	three	three	NUM
cajgh-29	134	57	mutations	mutation	NOUN
cajgh-29	134	58	in	in	ADP
cajgh-29	134	59	brca2	brca2	PROPN
cajgh-29	134	60	(	(	PUNCT
cajgh-29	134	61	c.2127t	c.2127t	PROPN
cajgh-29	134	62	>	>	X
cajgh-29	134	63	c	c	X
cajgh-29	134	64	,	,	PUNCT
cajgh-29	134	65	c.2410g	c.2410g	NOUN
cajgh-29	134	66	>	>	X
cajgh-29	134	67	a	a	PRON
cajgh-29	134	68	,	,	PUNCT
cajgh-29	134	69	c.10234a	c.10234a	NOUN
cajgh-29	134	70	>	>	X
cajgh-29	134	71	g	g	NOUN
cajgh-29	134	72	)	)	PUNCT
cajgh-29	134	73	are	be	AUX
cajgh-29	134	74	neutral	neutral	ADJ
cajgh-29	134	75	polymorphisms	polymorphism	NOUN
cajgh-29	134	76	,	,	PUNCT
cajgh-29	134	77	in	in	ADP
cajgh-29	134	78	view	view	NOUN
cajgh-29	134	79	of	of	ADP
cajgh-29	134	80	the	the	DET
cajgh-29	134	81	relatively	relatively	ADV
cajgh-29	134	82	high	high	ADJ
cajgh-29	134	83	allele	allele	NOUN
cajgh-29	134	84	frequencies	frequency	NOUN
cajgh-29	134	85	(	(	PUNCT
cajgh-29	134	86	>	>	SYM
cajgh-29	134	87	30	30	NUM
cajgh-29	134	88	%	%	NOUN
cajgh-29	134	89	)	)	PUNCT
cajgh-29	134	90	of	of	ADP
cajgh-29	134	91	these	these	DET
cajgh-29	134	92	variants	variant	NOUN
cajgh-29	134	93	.	.	PUNCT
cajgh-29	135	1	because	because	SCONJ
cajgh-29	135	2	of	of	ADP
cajgh-29	135	3	the	the	DET
cajgh-29	135	4	unavailability	unavailability	NOUN
cajgh-29	135	5	of	of	ADP
cajgh-29	135	6	a	a	DET
cajgh-29	135	7	functional	functional	ADJ
cajgh-29	135	8	brca	brca	NOUN
cajgh-29	135	9	protein	protein	NOUN
cajgh-29	135	10	assay	assay	NOUN
cajgh-29	135	11	system	system	NOUN
cajgh-29	135	12	,	,	PUNCT
cajgh-29	135	13	the	the	DET
cajgh-29	135	14	disease	disease	NOUN
cajgh-29	135	15	associations	association	NOUN
cajgh-29	135	16	of	of	ADP
cajgh-29	135	17	other	other	ADJ
cajgh-29	135	18	mutations	mutation	NOUN
cajgh-29	135	19	remain	remain	VERB
cajgh-29	135	20	uncertain	uncertain	ADJ
cajgh-29	135	21	.	.	PUNCT
cajgh-29	136	1	however	however	ADV
cajgh-29	136	2	,	,	PUNCT
cajgh-29	136	3	the	the	DET
cajgh-29	136	4	possibility	possibility	NOUN
cajgh-29	136	5	can	can	AUX
cajgh-29	136	6	not	not	PART
cajgh-29	136	7	be	be	AUX
cajgh-29	136	8	ruled	rule	VERB
cajgh-29	136	9	out	out	ADP
cajgh-29	136	10	that	that	SCONJ
cajgh-29	136	11	some	some	PRON
cajgh-29	136	12	of	of	ADP
cajgh-29	136	13	these	these	DET
cajgh-29	136	14	unverified	unverified	ADJ
cajgh-29	136	15	variants	variant	NOUN
cajgh-29	136	16	are	be	AUX
cajgh-29	136	17	pathogenically	pathogenically	ADV
cajgh-29	136	18	relevant	relevant	ADJ
cajgh-29	136	19	.	.	PUNCT
cajgh-29	137	1	no	no	DET
cajgh-29	137	2	deleterious	deleterious	ADJ
cajgh-29	137	3	mutations	mutation	NOUN
cajgh-29	137	4	were	be	AUX
cajgh-29	137	5	detected	detect	VERB
cajgh-29	137	6	in	in	ADP
cajgh-29	137	7	either	either	DET
cajgh-29	137	8	gene	gene	NOUN
cajgh-29	137	9	among	among	ADP
cajgh-29	137	10	studied	study	VERB
cajgh-29	137	11	groups	group	NOUN
cajgh-29	137	12	.	.	PUNCT
cajgh-29	138	1	the	the	DET
cajgh-29	138	2	lack	lack	NOUN
cajgh-29	138	3	in	in	ADP
cajgh-29	138	4	the	the	DET
cajgh-29	138	5	germline	germline	NOUN
cajgh-29	138	6	of	of	ADP
cajgh-29	138	7	clearly	clearly	ADV
cajgh-29	138	8	deleterious	deleterious	ADJ
cajgh-29	138	9	alterations	alteration	NOUN
cajgh-29	138	10	might	might	AUX
cajgh-29	138	11	be	be	AUX
cajgh-29	138	12	unsurprising	unsurprising	ADJ
cajgh-29	138	13	.	.	PUNCT
cajgh-29	139	1	in	in	ADP
cajgh-29	139	2	fact	fact	NOUN
cajgh-29	139	3	,	,	PUNCT
cajgh-29	139	4	these	these	PRON
cajgh-29	139	5	are	be	AUX
cajgh-29	139	6	extremely	extremely	ADV
cajgh-29	139	7	rare	rare	ADJ
cajgh-29	139	8	in	in	ADP
cajgh-29	139	9	patients	patient	NOUN
cajgh-29	139	10	not	not	PART
cajgh-29	139	11	selected	select	VERB
cajgh-29	139	12	due	due	ADP
cajgh-29	139	13	to	to	ADP
cajgh-29	139	14	a	a	DET
cajgh-29	139	15	family	family	NOUN
cajgh-29	139	16	history	history	NOUN
cajgh-29	139	17	and/or	and/or	CCONJ
cajgh-29	139	18	early	early	ADJ
cajgh-29	139	19	disease	disease	NOUN
cajgh-29	139	20	onset.41	onset.41	NOUN
cajgh-29	139	21	however	however	ADV
cajgh-29	139	22	,	,	PUNCT
cajgh-29	139	23	the	the	DET
cajgh-29	139	24	true	true	ADJ
cajgh-29	139	25	contribution	contribution	NOUN
cajgh-29	139	26	made	make	VERB
cajgh-29	139	27	by	by	ADP
cajgh-29	139	28	the	the	DET
cajgh-29	139	29	brca	brca	PROPN
cajgh-29	139	30	genes	gene	NOUN
cajgh-29	139	31	to	to	ADP
cajgh-29	139	32	sporadic	sporadic	ADJ
cajgh-29	139	33	breast	breast	NOUN
cajgh-29	139	34	cancer	cancer	NOUN
cajgh-29	139	35	remains	remain	VERB
cajgh-29	139	36	controversial	controversial	ADJ
cajgh-29	139	37	for	for	ADP
cajgh-29	139	38	a	a	DET
cajgh-29	139	39	number	number	NOUN
cajgh-29	139	40	of	of	ADP
cajgh-29	139	41	reasons	reason	NOUN
cajgh-29	139	42	.	.	PUNCT
cajgh-29	140	1	first	first	ADV
cajgh-29	140	2	,	,	PUNCT
cajgh-29	140	3	missense	missense	VERB
cajgh-29	140	4	mutations	mutation	NOUN
cajgh-29	140	5	with	with	ADP
cajgh-29	140	6	an	an	DET
cajgh-29	140	7	unknown	unknown	ADJ
cajgh-29	140	8	significance	significance	NOUN
cajgh-29	140	9	could	could	AUX
cajgh-29	140	10	have	have	VERB
cajgh-29	140	11	a	a	DET
cajgh-29	140	12	pathogenic	pathogenic	ADJ
cajgh-29	140	13	effect	effect	NOUN
cajgh-29	140	14	.	.	PUNCT
cajgh-29	141	1	secondly	secondly	ADV
cajgh-29	141	2	,	,	PUNCT
cajgh-29	141	3	in	in	ADP
cajgh-29	141	4	addition	addition	NOUN
cajgh-29	141	5	to	to	ADP
cajgh-29	141	6	missense	missense	VERB
cajgh-29	141	7	mutations	mutation	NOUN
cajgh-29	141	8	,	,	PUNCT
cajgh-29	141	9	silent	silent	ADJ
cajgh-29	141	10	polymorphisms	polymorphism	NOUN
cajgh-29	141	11	may	may	AUX
cajgh-29	141	12	affect	affect	VERB
cajgh-29	141	13	the	the	DET
cajgh-29	141	14	splicing	splicing	NOUN
cajgh-29	141	15	mechanism	mechanism	NOUN
cajgh-29	141	16	.	.	PUNCT
cajgh-29	142	1	however	however	ADV
cajgh-29	142	2	,	,	PUNCT
cajgh-29	142	3	these	these	DET
cajgh-29	142	4	variants	variant	NOUN
cajgh-29	142	5	can	can	AUX
cajgh-29	142	6	not	not	PART
cajgh-29	142	7	be	be	AUX
cajgh-29	142	8	classified	classify	VERB
cajgh-29	142	9	as	as	ADP
cajgh-29	142	10	disease	disease	NOUN
cajgh-29	142	11	associated	associate	VERB
cajgh-29	142	12	in	in	ADP
cajgh-29	142	13	the	the	DET
cajgh-29	142	14	absence	absence	NOUN
cajgh-29	142	15	of	of	ADP
cajgh-29	142	16	a	a	DET
cajgh-29	142	17	good	good	ADJ
cajgh-29	142	18	functional	functional	ADJ
cajgh-29	142	19	assay	assay	NOUN
cajgh-29	142	20	system	system	NOUN
cajgh-29	142	21	for	for	ADP
cajgh-29	142	22	brca1	brca1	PROPN
cajgh-29	142	23	and	and	CCONJ
cajgh-29	142	24	brca2	brca2	PROPN
cajgh-29	142	25	.	.	PUNCT
cajgh-29	143	1	when	when	SCONJ
cajgh-29	143	2	a	a	DET
cajgh-29	143	3	functional	functional	ADJ
cajgh-29	143	4	assay	assay	NOUN
cajgh-29	143	5	becomes	become	VERB
cajgh-29	143	6	available	available	ADJ
cajgh-29	143	7	,	,	PUNCT
cajgh-29	143	8	it	it	PRON
cajgh-29	143	9	will	will	AUX
cajgh-29	143	10	be	be	AUX
cajgh-29	143	11	important	important	ADJ
cajgh-29	143	12	to	to	PART
cajgh-29	143	13	elucidate	elucidate	VERB
cajgh-29	143	14	the	the	DET
cajgh-29	143	15	relevance	relevance	NOUN
cajgh-29	143	16	of	of	ADP
cajgh-29	143	17	such	such	ADJ
cajgh-29	143	18	variations	variation	NOUN
cajgh-29	143	19	with	with	ADP
cajgh-29	143	20	unknown	unknown	ADJ
cajgh-29	143	21	clinical	clinical	ADJ
cajgh-29	143	22	significances	significance	NOUN
cajgh-29	143	23	.	.	PUNCT
cajgh-29	144	1	to	to	ADP
cajgh-29	144	2	our	our	PRON
cajgh-29	144	3	knowledge	knowledge	NOUN
cajgh-29	144	4	,	,	PUNCT
cajgh-29	144	5	this	this	DET
cajgh-29	144	6	report	report	NOUN
cajgh-29	144	7	is	be	AUX
cajgh-29	144	8	the	the	DET
cajgh-29	144	9	first	first	ADJ
cajgh-29	144	10	to	to	PART
cajgh-29	144	11	include	include	VERB
cajgh-29	144	12	information	information	NOUN
cajgh-29	144	13	on	on	ADP
cajgh-29	144	14	the	the	DET
cajgh-29	144	15	prevalence	prevalence	NOUN
cajgh-29	144	16	of	of	ADP
cajgh-29	144	17	missense	missense	NOUN
cajgh-29	144	18	mutations	mutation	NOUN
cajgh-29	144	19	of	of	ADP
cajgh-29	144	20	unknown	unknown	ADJ
cajgh-29	144	21	significance	significance	NOUN
cajgh-29	144	22	,	,	PUNCT
cajgh-29	144	23	and	and	CCONJ
cajgh-29	144	24	to	to	PART
cajgh-29	144	25	provide	provide	VERB
cajgh-29	144	26	information	information	NOUN
cajgh-29	144	27	on	on	ADP
cajgh-29	144	28	polymorphisms	polymorphism	NOUN
cajgh-29	144	29	in	in	ADP
cajgh-29	144	30	the	the	DET
cajgh-29	144	31	kazakhstan	kazakhstan	PROPN
cajgh-29	144	32	population	population	NOUN
cajgh-29	144	33	in	in	ADP
cajgh-29	144	34	both	both	DET
cajgh-29	144	35	brca1	brca1	PROPN
cajgh-29	144	36	and	and	CCONJ
cajgh-29	144	37	brca2	brca2	NOUN
cajgh-29	144	38	genes	gene	NOUN
cajgh-29	144	39	.	.	PUNCT
cajgh-29	145	1	moreover	moreover	ADV
cajgh-29	145	2	,	,	PUNCT
cajgh-29	145	3	these	these	DET
cajgh-29	145	4	kazakhstan	kazakhstan	ADJ
cajgh-29	145	5	population	population	NOUN
cajgh-29	145	6	-	-	PUNCT
cajgh-29	145	7	based	base	VERB
cajgh-29	145	8	polymorphisms	polymorphism	NOUN
cajgh-29	145	9	could	could	AUX
cajgh-29	145	10	be	be	AUX
cajgh-29	145	11	used	use	VERB
cajgh-29	145	12	as	as	ADP
cajgh-29	145	13	potential	potential	ADJ
cajgh-29	145	14	markers	marker	NOUN
cajgh-29	145	15	.	.	PUNCT
cajgh-29	146	1	missense	missense	NOUN
cajgh-29	146	2	mutation	mutation	NOUN
cajgh-29	146	3	q356r	q356r	PROPN
cajgh-29	146	4	in	in	ADP
cajgh-29	146	5	brca1	brca1	PROPN
cajgh-29	146	6	was	be	AUX
cajgh-29	146	7	detected	detect	VERB
cajgh-29	146	8	in	in	ADP
cajgh-29	146	9	11	11	NUM
cajgh-29	146	10	(	(	PUNCT
cajgh-29	146	11	7.2	7.2	NUM
cajgh-29	146	12	%	%	NOUN
cajgh-29	146	13	)	)	PUNCT
cajgh-29	146	14	breast	breast	NOUN
cajgh-29	146	15	cancer	cancer	NOUN
cajgh-29	146	16	cases	case	NOUN
cajgh-29	146	17	and	and	CCONJ
cajgh-29	146	18	10	10	NUM
cajgh-29	146	19	(	(	PUNCT
cajgh-29	146	20	8.9	8.9	NUM
cajgh-29	146	21	%	%	NOUN
cajgh-29	146	22	)	)	PUNCT
cajgh-29	146	23	control	control	NOUN
cajgh-29	146	24	subjects	subject	NOUN
cajgh-29	146	25	.	.	PUNCT
cajgh-29	147	1	a	a	DET
cajgh-29	147	2	study	study	NOUN
cajgh-29	147	3	on	on	ADP
cajgh-29	147	4	the	the	DET
cajgh-29	147	5	brca1	brca1	PROPN
cajgh-29	147	6	polymorphisms	polymorphism	NOUN
cajgh-29	147	7	reported	report	VERB
cajgh-29	147	8	that	that	SCONJ
cajgh-29	147	9	the	the	DET
cajgh-29	147	10	arg356	arg356	PROPN
cajgh-29	147	11	allele	allele	NOUN
cajgh-29	147	12	had	have	VERB
cajgh-29	147	13	a	a	DET
cajgh-29	147	14	higher	high	ADJ
cajgh-29	147	15	genotype	genotype	NOUN
cajgh-29	147	16	distribution	distribution	NOUN
cajgh-29	147	17	in	in	ADP
cajgh-29	147	18	healthy	healthy	ADJ
cajgh-29	147	19	controls	control	NOUN
cajgh-29	147	20	than	than	ADP
cajgh-29	147	21	in	in	ADP
cajgh-29	147	22	breast	breast	NOUN
cajgh-29	147	23	cancer	cancer	NOUN
cajgh-29	147	24	patients30	patients30	NOUN
cajgh-29	147	25	and	and	CCONJ
cajgh-29	147	26	may	may	AUX
cajgh-29	147	27	thus	thus	ADV
cajgh-29	147	28	play	play	VERB
cajgh-29	147	29	a	a	DET
cajgh-29	147	30	protective	protective	ADJ
cajgh-29	147	31	role	role	NOUN
cajgh-29	147	32	against	against	ADP
cajgh-29	147	33	breast	breast	NOUN
cajgh-29	147	34	cancer	cancer	NOUN
cajgh-29	147	35	.	.	PUNCT
cajgh-29	148	1	in	in	ADP
cajgh-29	148	2	this	this	DET
cajgh-29	148	3	study	study	NOUN
cajgh-29	148	4	,	,	PUNCT
cajgh-29	148	5	the	the	DET
cajgh-29	148	6	polymorphism	polymorphism	NOUN
cajgh-29	148	7	at	at	ADP
cajgh-29	148	8	codon	codon	PROPN
cajgh-29	148	9	356	356	NUM
cajgh-29	148	10	in	in	ADP
cajgh-29	148	11	the	the	DET
cajgh-29	148	12	brca1	brca1	PROPN
cajgh-29	148	13	gene	gene	NOUN
cajgh-29	148	14	had	have	AUX
cajgh-29	148	15	previously	previously	ADV
cajgh-29	148	16	been	be	AUX
cajgh-29	148	17	described	describe	VERB
cajgh-29	148	18	as	as	ADP
cajgh-29	148	19	being	be	AUX
cajgh-29	148	20	inversely	inversely	ADV
cajgh-29	148	21	associated	associate	VERB
cajgh-29	148	22	with	with	ADP
cajgh-29	148	23	breast	breast	NOUN
cajgh-29	148	24	cancer	cancer	NOUN
cajgh-29	148	25	risk	risk	NOUN
cajgh-29	148	26	(	(	PUNCT
cajgh-29	148	27	gln356→	gln356→	PROPN
cajgh-29	148	28	arg	arg	NOUN
cajgh-29	148	29	,	,	PUNCT
cajgh-29	148	30	or	or	CCONJ
cajgh-29	148	31	0.88	0.88	NUM
cajgh-29	148	32	,	,	PUNCT
cajgh-29	148	33	95	95	NUM
cajgh-29	148	34	%	%	NOUN
cajgh-29	148	35	confidence	confidence	NOUN
cajgh-29	148	36	interval	interval	NOUN
cajgh-29	149	1	[	[	X
cajgh-29	149	2	ci	ci	X
cajgh-29	149	3	]	]	X
cajgh-29	149	4	0.63–1.23	0.63–1.23	NOUN
cajgh-29	149	5	;	;	PUNCT
cajgh-29	149	6	arg356→	arg356→	PROPN
cajgh-29	149	7	arg	arg	PROPN
cajgh-29	149	8	,	,	PUNCT
cajgh-29	149	9	or	or	CCONJ
cajgh-29	149	10	0.00	0.00	NUM
cajgh-29	149	11	,	,	PUNCT
cajgh-29	149	12	95	95	NUM
cajgh-29	149	13	%	%	NOUN
cajgh-29	149	14	ci	ci	NOUN
cajgh-29	149	15	0.00–0.56).30	0.00–0.56).30	NUM
cajgh-29	149	16	another	another	DET
cajgh-29	149	17	study	study	NOUN
cajgh-29	149	18	showed	show	VERB
cajgh-29	149	19	that	that	SCONJ
cajgh-29	149	20	q356r	q356r	PROPN
cajgh-29	149	21	polymorphism	polymorphism	NOUN
cajgh-29	149	22	was	be	AUX
cajgh-29	149	23	significantly	significantly	ADV
cajgh-29	149	24	associated	associate	VERB
cajgh-29	149	25	with	with	ADP
cajgh-29	149	26	family	family	NOUN
cajgh-29	149	27	history	history	NOUN
cajgh-29	149	28	of	of	ADP
cajgh-29	149	29	ovarian	ovarian	ADJ
cajgh-29	149	30	cancer	cancer	NOUN
cajgh-29	149	31	,	,	PUNCT
cajgh-29	149	32	suggesting	suggest	VERB
cajgh-29	149	33	that	that	SCONJ
cajgh-29	149	34	this	this	DET
cajgh-29	149	35	sequence	sequence	NOUN
cajgh-29	149	36	variant	variant	NOUN
cajgh-29	149	37	may	may	AUX
cajgh-29	149	38	increase	increase	VERB
cajgh-29	149	39	ovarian	ovarian	ADJ
cajgh-29	149	40	cancer	cancer	NOUN
cajgh-29	149	41	risk.31	risk.31	NOUN
cajgh-29	149	42	in	in	ADP
cajgh-29	149	43	contrast	contrast	NOUN
cajgh-29	149	44	,	,	PUNCT
cajgh-29	149	45	tommasi	tommasi	PROPN
cajgh-29	149	46	et	et	NOUN
cajgh-29	149	47	al.47	al.47	PROPN
cajgh-29	149	48	analyzed	analyze	VERB
cajgh-29	149	49	brca1	brca1	PROPN
cajgh-29	149	50	mutational	mutational	ADJ
cajgh-29	149	51	risk	risk	NOUN
cajgh-29	149	52	using	use	VERB
cajgh-29	149	53	myriad	myriad	ADJ
cajgh-29	149	54	ii	ii	NOUN
cajgh-29	149	55	software	software	NOUN
cajgh-29	149	56	and	and	CCONJ
cajgh-29	149	57	showed	show	VERB
cajgh-29	149	58	that	that	SCONJ
cajgh-29	149	59	k1183r	k1183r	NOUN
cajgh-29	149	60	,	,	PUNCT
cajgh-29	149	61	the	the	DET
cajgh-29	149	62	polymorphism	polymorphism	NOUN
cajgh-29	149	63	in	in	ADP
cajgh-29	149	64	exon	exon	NOUN
cajgh-29	149	65	11	11	NUM
cajgh-29	149	66	as	as	SCONJ
cajgh-29	149	67	reported	report	VERB
cajgh-29	149	68	in	in	ADP
cajgh-29	149	69	bic,26	bic,26	NOUN
cajgh-29	149	70	resulted	result	VERB
cajgh-29	149	71	inversely	inversely	ADV
cajgh-29	149	72	related	relate	VERB
cajgh-29	149	73	with	with	ADP
cajgh-29	149	74	brca1	brca1	PROPN
cajgh-29	149	75	mutation	mutation	NOUN
cajgh-29	149	76	carrier	carrier	NOUN
cajgh-29	149	77	status	status	NOUN
cajgh-29	149	78	.	.	PUNCT
cajgh-29	150	1	also	also	ADV
cajgh-29	150	2	they	they	PRON
cajgh-29	150	3	showed	show	VERB
cajgh-29	150	4	that	that	SCONJ
cajgh-29	150	5	brca1	brca1	PROPN
cajgh-29	150	6	sequence	sequence	NOUN
cajgh-29	150	7	alterations	alteration	NOUN
cajgh-29	150	8	such	such	ADJ
cajgh-29	150	9	as	as	ADP
cajgh-29	150	10	p871l	p871l	PROPN
cajgh-29	150	11	and	and	CCONJ
cajgh-29	150	12	e1038	e1038	PROPN
cajgh-29	150	13	g	g	NOUN
cajgh-29	150	14	were	be	AUX
cajgh-29	150	15	not	not	PART
cajgh-29	150	16	significantly	significantly	ADV
cajgh-29	150	17	related	relate	VERB
cajgh-29	150	18	with	with	ADP
cajgh-29	150	19	higher	high	ADJ
cajgh-29	150	20	brca1	brca1	PROPN
cajgh-29	150	21	mutational	mutational	ADJ
cajgh-29	150	22	risk.47	risk.47	NOUN
cajgh-29	150	23	this	this	DET
cajgh-29	150	24	data	data	NOUN
cajgh-29	150	25	leads	lead	VERB
cajgh-29	150	26	us	we	PRON
cajgh-29	150	27	to	to	PART
cajgh-29	150	28	suggest	suggest	VERB
cajgh-29	150	29	further	further	ADJ
cajgh-29	150	30	investigation	investigation	NOUN
cajgh-29	150	31	of	of	ADP
cajgh-29	150	32	the	the	DET
cajgh-29	150	33	effects	effect	NOUN
cajgh-29	150	34	of	of	ADP
cajgh-29	150	35	these	these	DET
cajgh-29	150	36	sequence	sequence	NOUN
cajgh-29	150	37	variants	variant	NOUN
cajgh-29	150	38	on	on	ADP
cajgh-29	150	39	brca1	brca1	PROPN
cajgh-29	150	40	activity	activity	NOUN
cajgh-29	150	41	to	to	PART
cajgh-29	150	42	understand	understand	VERB
cajgh-29	150	43	whether	whether	SCONJ
cajgh-29	150	44	these	these	DET
cajgh-29	150	45	variations	variation	NOUN
cajgh-29	150	46	have	have	VERB
cajgh-29	150	47	any	any	DET
cajgh-29	150	48	pathological	pathological	ADJ
cajgh-29	150	49	role	role	NOUN
cajgh-29	150	50	.	.	PUNCT
cajgh-29	151	1	we	we	PRON
cajgh-29	151	2	found	find	VERB
cajgh-29	151	3	that	that	SCONJ
cajgh-29	151	4	79	79	NUM
cajgh-29	151	5	of	of	ADP
cajgh-29	151	6	156	156	NUM
cajgh-29	151	7	women	woman	NOUN
cajgh-29	151	8	(	(	PUNCT
cajgh-29	151	9	71.2	71.2	NUM
cajgh-29	151	10	%	%	NOUN
cajgh-29	151	11	)	)	PUNCT
cajgh-29	151	12	carried	carry	VERB
cajgh-29	151	13	4	4	NUM
cajgh-29	151	14	-	-	SYM
cajgh-29	151	15	6	6	NUM
cajgh-29	151	16	alterations	alteration	NOUN
cajgh-29	151	17	.	.	PUNCT
cajgh-29	152	1	this	this	PRON
cajgh-29	152	2	may	may	AUX
cajgh-29	152	3	be	be	AUX
cajgh-29	152	4	due	due	ADJ
cajgh-29	152	5	to	to	ADP
cajgh-29	152	6	polymorphisms	polymorphism	NOUN
cajgh-29	152	7	located	locate	VERB
cajgh-29	152	8	in	in	ADP
cajgh-29	152	9	one	one	NUM
cajgh-29	152	10	haplogroup	haplogroup	NOUN
cajgh-29	152	11	that	that	PRON
cajgh-29	152	12	are	be	AUX
cajgh-29	152	13	inherited	inherit	VERB
cajgh-29	152	14	together	together	ADV
cajgh-29	152	15	.	.	PUNCT
cajgh-29	153	1	dunning	dun	VERB
cajgh-29	153	2	et	et	NOUN
cajgh-29	153	3	al	al	PROPN
cajgh-29	153	4	examined	examine	VERB
cajgh-29	153	5	the	the	DET
cajgh-29	153	6	frequency	frequency	NOUN
cajgh-29	153	7	of	of	ADP
cajgh-29	153	8	four	four	NUM
cajgh-29	153	9	polymorphisms	polymorphism	NOUN
cajgh-29	153	10	:	:	PUNCT
cajgh-29	153	11	gln356arg	gln356arg	NOUN
cajgh-29	153	12	,	,	PUNCT
cajgh-29	153	13	pro871leu	pro871leu	NOUN
cajgh-29	153	14	,	,	PUNCT
cajgh-29	153	15	glu1038gly	glu1038gly	ADV
cajgh-29	153	16	and	and	CCONJ
cajgh-29	153	17	ser1613gly	ser1613gly	ADV
cajgh-29	153	18	in	in	ADP
cajgh-29	153	19	large	large	ADJ
cajgh-29	153	20	series	series	NOUN
cajgh-29	153	21	of	of	ADP
cajgh-29	153	22	breast	breast	NOUN
cajgh-29	153	23	and	and	CCONJ
cajgh-29	153	24	ovarian	ovarian	ADJ
cajgh-29	153	25	cancer	cancer	NOUN
cajgh-29	153	26	cases	case	NOUN
cajgh-29	153	27	and	and	CCONJ
cajgh-29	153	28	matched	match	VERB
cajgh-29	153	29	controls.30	controls.30	NOUN
cajgh-29	153	30	.	.	PUNCT
cajgh-29	154	1	due	due	ADP
cajgh-29	154	2	to	to	ADP
cajgh-29	154	3	strong	strong	ADJ
cajgh-29	154	4	linkage	linkage	NOUN
cajgh-29	154	5	disequilibrium	disequilibrium	NOUN
cajgh-29	154	6	,	,	PUNCT
cajgh-29	154	7	these	these	DET
cajgh-29	154	8	four	four	NUM
cajgh-29	154	9	sites	site	NOUN
cajgh-29	154	10	generate	generate	VERB
cajgh-29	154	11	only	only	ADV
cajgh-29	154	12	three	three	NUM
cajgh-29	154	13	haplotypes	haplotype	NOUN
cajgh-29	154	14	with	with	ADP
cajgh-29	154	15	a	a	DET
cajgh-29	154	16	frequency	frequency	NOUN
cajgh-29	154	17	>	>	ADP
cajgh-29	154	18	1.3	1.3	NUM
cajgh-29	154	19	%	%	NOUN
cajgh-29	154	20	.	.	PUNCT
cajgh-29	155	1	the	the	DET
cajgh-29	155	2	two	two	NUM
cajgh-29	155	3	most	most	ADV
cajgh-29	155	4	common	common	ADJ
cajgh-29	155	5	haplotypes	haplotype	NOUN
cajgh-29	155	6	,	,	PUNCT
cajgh-29	155	7	defined	define	VERB
cajgh-29	155	8	by	by	ADP
cajgh-29	155	9	the	the	DET
cajgh-29	155	10	alleles	allele	NOUN
cajgh-29	155	11	gln356pro871glu1038ser1613	gln356pro871glu1038ser1613	PUNCT
cajgh-29	155	12	and	and	CCONJ
cajgh-29	155	13	gln356leu871gly1038gly1613	gln356leu871gly1038gly1613	PROPN
cajgh-29	155	14	,	,	PUNCT
cajgh-29	155	15	have	have	VERB
cajgh-29	155	16	frequencies	frequency	NOUN
cajgh-29	155	17	of	of	ADP
cajgh-29	155	18	0.57	0.57	NUM
cajgh-29	155	19	and	and	CCONJ
cajgh-29	155	20	0.32	0.32	NUM
cajgh-29	155	21	,	,	PUNCT
cajgh-29	155	22	respectively	respectively	ADV
cajgh-29	155	23	,	,	PUNCT
cajgh-29	155	24	and	and	CCONJ
cajgh-29	155	25	these	these	DET
cajgh-29	155	26	frequencies	frequency	NOUN
cajgh-29	155	27	do	do	AUX
cajgh-29	155	28	not	not	PART
cajgh-29	155	29	differ	differ	VERB
cajgh-29	155	30	significantly	significantly	ADV
cajgh-29	155	31	between	between	ADP
cajgh-29	155	32	patient	patient	NOUN
cajgh-29	155	33	and	and	CCONJ
cajgh-29	155	34	control	control	NOUN
cajgh-29	155	35	groups	group	NOUN
cajgh-29	155	36	,	,	PUNCT
cajgh-29	155	37	indicating	indicate	VERB
cajgh-29	155	38	that	that	SCONJ
cajgh-29	155	39	the	the	DET
cajgh-29	155	40	most	most	ADV
cajgh-29	155	41	common	common	ADJ
cajgh-29	155	42	polymorphisms	polymorphism	NOUN
cajgh-29	155	43	of	of	ADP
cajgh-29	155	44	the	the	DET
cajgh-29	155	45	brca1	brca1	PROPN
cajgh-29	155	46	gene	gene	NOUN
cajgh-29	155	47	do	do	AUX
cajgh-29	155	48	not	not	PART
cajgh-29	155	49	make	make	VERB
cajgh-29	155	50	a	a	DET
cajgh-29	155	51	significant	significant	ADJ
cajgh-29	155	52	contribution	contribution	NOUN
cajgh-29	155	53	to	to	ADP
cajgh-29	155	54	breast	breast	NOUN
cajgh-29	155	55	or	or	CCONJ
cajgh-29	155	56	ovarian	ovarian	ADJ
cajgh-29	155	57	cancer	cancer	NOUN
cajgh-29	155	58	risk.30	risk.30	VERB
cajgh-29	155	59	common	common	ADJ
cajgh-29	155	60	polymorphisms	polymorphism	NOUN
cajgh-29	155	61	in	in	ADP
cajgh-29	155	62	brca1/2	brca1/2	ADJ
cajgh-29	155	63	genes	gene	NOUN
cajgh-29	155	64	appear	appear	VERB
cajgh-29	155	65	to	to	PART
cajgh-29	155	66	be	be	AUX
cajgh-29	155	67	highly	highly	ADV
cajgh-29	155	68	prevalent	prevalent	ADJ
cajgh-29	155	69	in	in	ADP
cajgh-29	155	70	kazakhstan	kazakhstan	PROPN
cajgh-29	155	71	breast	breast	NOUN
cajgh-29	155	72	cancer	cancer	NOUN
cajgh-29	155	73	cases	case	NOUN
cajgh-29	155	74	and	and	CCONJ
cajgh-29	155	75	in	in	ADP
cajgh-29	155	76	healthy	healthy	ADJ
cajgh-29	155	77	controls	control	NOUN
cajgh-29	155	78	which	which	PRON
cajgh-29	155	79	is	be	AUX
cajgh-29	155	80	in	in	ADP
cajgh-29	155	81	concordance	concordance	NOUN
cajgh-29	155	82	with	with	ADP
cajgh-29	155	83	previously	previously	ADV
cajgh-29	155	84	reported	report	VERB
cajgh-29	155	85	findings	finding	NOUN
cajgh-29	155	86	in	in	ADP
cajgh-29	155	87	some	some	DET
cajgh-29	155	88	asian	asian	ADJ
cajgh-29	155	89	and	and	CCONJ
cajgh-29	155	90	european	european	ADJ
cajgh-29	155	91	populations.37	populations.37	PROPN
cajgh-29	155	92	-	-	PUNCT
cajgh-29	155	93	43	43	NUM
cajgh-29	155	94	,	,	PUNCT
cajgh-29	155	95	47	47	NUM
cajgh-29	155	96	-	-	SYM
cajgh-29	155	97	49	49	NUM
cajgh-29	155	98	frequencies	frequency	NOUN
cajgh-29	155	99	of	of	ADP
cajgh-29	155	100	these	these	DET
cajgh-29	155	101	polymorphisms	polymorphism	NOUN
cajgh-29	155	102	were	be	AUX
cajgh-29	155	103	higher	high	ADJ
cajgh-29	155	104	in	in	ADP
cajgh-29	155	105	breast	breast	NOUN
cajgh-29	155	106	cancer	cancer	NOUN
cajgh-29	155	107	cases	case	NOUN
cajgh-29	155	108	vs	vs	ADP
cajgh-29	155	109	controls	control	NOUN
cajgh-29	155	110	,	,	PUNCT
cajgh-29	155	111	particularly	particularly	ADV
cajgh-29	155	112	in	in	ADP
cajgh-29	155	113	the	the	DET
cajgh-29	155	114	brca2	brca2	NOUN
cajgh-29	155	115	gene	gene	NOUN
cajgh-29	155	116	,	,	PUNCT
cajgh-29	155	117	p<0.05	p<0.05	NOUN
cajgh-29	155	118	.	.	PUNCT
cajgh-29	155	119	to	to	ADP
cajgh-29	155	120	date	date	NOUN
cajgh-29	155	121	,	,	PUNCT
cajgh-29	155	122	there	there	PRON
cajgh-29	155	123	is	be	VERB
cajgh-29	155	124	little	little	ADJ
cajgh-29	155	125	evidence	evidence	NOUN
cajgh-29	155	126	that	that	SCONJ
cajgh-29	155	127	highly	highly	ADV
cajgh-29	155	128	penetrant	penetrant	NOUN
cajgh-29	155	129	,	,	PUNCT
cajgh-29	155	130	germline	germline	NOUN
cajgh-29	155	131	mutations	mutation	NOUN
cajgh-29	155	132	in	in	ADP
cajgh-29	155	133	brca1/2	brca1/2	PROPN
cajgh-29	155	134	are	be	AUX
cajgh-29	155	135	observed	observe	VERB
cajgh-29	155	136	in	in	ADP
cajgh-29	155	137	sporadic	sporadic	ADJ
cajgh-29	155	138	cases	case	NOUN
cajgh-29	155	139	,	,	PUNCT
cajgh-29	155	140	but	but	CCONJ
cajgh-29	155	141	whether	whether	SCONJ
cajgh-29	155	142	common	common	ADJ
cajgh-29	155	143	polymorphisms	polymorphism	NOUN
cajgh-29	155	144	play	play	VERB
cajgh-29	155	145	a	a	DET
cajgh-29	155	146	role	role	NOUN
cajgh-29	155	147	in	in	ADP
cajgh-29	155	148	disease	disease	NOUN
cajgh-29	155	149	risk	risk	NOUN
cajgh-29	155	150	is	be	AUX
cajgh-29	155	151	still	still	ADV
cajgh-29	155	152	controversial	controversial	ADJ
cajgh-29	155	153	.	.	PUNCT
cajgh-29	156	1	the	the	DET
cajgh-29	156	2	roles	role	NOUN
cajgh-29	156	3	of	of	ADP
cajgh-29	156	4	common	common	ADJ
cajgh-29	156	5	missense	missense	NOUN
cajgh-29	156	6	snps	snps	NOUN
cajgh-29	156	7	,	,	PUNCT
cajgh-29	156	8	as	as	ADV
cajgh-29	156	9	well	well	ADV
cajgh-29	156	10	as	as	ADP
cajgh-29	156	11	variation	variation	NOUN
cajgh-29	156	12	in	in	ADP
cajgh-29	156	13	noncoding	noncoding	ADJ
cajgh-29	156	14	regions	region	NOUN
cajgh-29	156	15	(	(	PUNCT
cajgh-29	156	16	that	that	PRON
cajgh-29	156	17	may	may	AUX
cajgh-29	156	18	influence	influence	VERB
cajgh-29	156	19	risk	risk	NOUN
cajgh-29	156	20	through	through	ADP
cajgh-29	156	21	expression	expression	NOUN
cajgh-29	156	22	levels	level	NOUN
cajgh-29	156	23	and	and	CCONJ
cajgh-29	156	24	alternative	alternative	ADJ
cajgh-29	156	25	splicing	splicing	NOUN
cajgh-29	156	26	)	)	PUNCT
cajgh-29	156	27	,	,	PUNCT
cajgh-29	156	28	have	have	VERB
cajgh-29	156	29	yet	yet	ADV
cajgh-29	156	30	to	to	PART
cajgh-29	156	31	be	be	AUX
cajgh-29	156	32	thoroughly	thoroughly	ADV
cajgh-29	156	33	explored	explore	VERB
cajgh-29	156	34	(	(	PUNCT
cajgh-29	156	35	at	at	ADP
cajgh-29	156	36	single	single	ADJ
cajgh-29	156	37	loci	locus	NOUN
cajgh-29	156	38	as	as	ADV
cajgh-29	156	39	well	well	ADV
cajgh-29	156	40	as	as	ADP
cajgh-29	156	41	throughout	throughout	ADP
cajgh-29	156	42	the	the	DET
cajgh-29	156	43	genome	genome	NOUN
cajgh-29	156	44	)	)	PUNCT
cajgh-29	156	45	as	as	ADP
cajgh-29	156	46	markers	marker	NOUN
cajgh-29	156	47	of	of	ADP
cajgh-29	156	48	breast	breast	NOUN
cajgh-29	156	49	cancer	cancer	NOUN
cajgh-29	156	50	susceptibility	susceptibility	NOUN
cajgh-29	156	51	.	.	PUNCT
cajgh-29	157	1	ongoing	ongoing	ADJ
cajgh-29	157	2	efforts	effort	NOUN
cajgh-29	157	3	to	to	PART
cajgh-29	157	4	systematically	systematically	ADV
cajgh-29	157	5	characterize	characterize	VERB
cajgh-29	157	6	genetic	genetic	ADJ
cajgh-29	157	7	polymorphisms	polymorphism	NOUN
cajgh-29	157	8	,	,	PUNCT
cajgh-29	157	9	such	such	ADJ
cajgh-29	157	10	as	as	ADP
cajgh-29	157	11	the	the	DET
cajgh-29	157	12	international	international	ADJ
cajgh-29	157	13	hapmap	hapmap	NOUN
cajgh-29	157	14	project,50	project,50	PROPN
cajgh-29	157	15	provide	provide	VERB
cajgh-29	157	16	the	the	DET
cajgh-29	157	17	foundation	foundation	NOUN
cajgh-29	157	18	for	for	ADP
cajgh-29	157	19	conducting	conduct	VERB
cajgh-29	157	20	comprehensive	comprehensive	ADJ
cajgh-29	157	21	association	association	NOUN
cajgh-29	157	22	studies	study	NOUN
cajgh-29	157	23	of	of	ADP
cajgh-29	157	24	common	common	ADJ
cajgh-29	157	25	variation	variation	NOUN
cajgh-29	157	26	.	.	PUNCT
cajgh-29	158	1	in	in	ADP
cajgh-29	158	2	a	a	DET
cajgh-29	158	3	large	large	ADJ
cajgh-29	158	4	study	study	NOUN
cajgh-29	158	5	,	,	PUNCT
cajgh-29	158	6	freedman	freedman	PROPN
cajgh-29	158	7	ml	ml	PROPN
cajgh-29	158	8	et	et	PROPN
cajgh-29	158	9	al	al	PROPN
cajgh-29	158	10	tested	test	VERB
cajgh-29	158	11	common	common	ADJ
cajgh-29	158	12	variation	variation	NOUN
cajgh-29	158	13	across	across	ADP
cajgh-29	158	14	the	the	DET
cajgh-29	158	15	brca1	brca1	NOUN
cajgh-29	158	16	locus	locus	NOUN
cajgh-29	158	17	in	in	ADP
cajgh-29	158	18	african	african	PROPN
cajgh-29	158	19	american	american	PROPN
cajgh-29	158	20	,	,	PUNCT
cajgh-29	158	21	native	native	ADJ
cajgh-29	158	22	hawaiian	hawaiian	PROPN
cajgh-29	158	23	,	,	PUNCT
cajgh-29	158	24	japanese	japanese	ADJ
cajgh-29	158	25	,	,	PUNCT
cajgh-29	158	26	latino	latino	ADJ
cajgh-29	158	27	,	,	PUNCT
cajgh-29	158	28	and	and	CCONJ
cajgh-29	158	29	white	white	ADJ
cajgh-29	158	30	women	woman	NOUN
cajgh-29	158	31	in	in	ADP
cajgh-29	158	32	the	the	DET
cajgh-29	158	33	multiethnic	multiethnic	ADJ
cajgh-29	158	34	cohort	cohort	NOUN
cajgh-29	158	35	study.51	study.51	PROPN
cajgh-29	158	36	28	28	NUM
cajgh-29	158	37	single	single	ADJ
cajgh-29	158	38	nucleotide	nucleotide	NOUN
cajgh-29	158	39	polymorphisms	polymorphism	NOUN
cajgh-29	158	40	(	(	PUNCT
cajgh-29	158	41	snps	snps	NOUN
cajgh-29	158	42	)	)	PUNCT
cajgh-29	158	43	spanning	span	VERB
cajgh-29	158	44	the	the	DET
cajgh-29	158	45	brca1	brca1	PROPN
cajgh-29	158	46	gene	gene	NOUN
cajgh-29	158	47	were	be	AUX
cajgh-29	158	48	used	use	VERB
cajgh-29	158	49	to	to	PART
cajgh-29	158	50	define	define	VERB
cajgh-29	158	51	patterns	pattern	NOUN
cajgh-29	158	52	of	of	ADP
cajgh-29	158	53	common	common	ADJ
cajgh-29	158	54	variation	variation	NOUN
cajgh-29	158	55	in	in	ADP
cajgh-29	158	56	these	these	DET
cajgh-29	158	57	populations	population	NOUN
cajgh-29	158	58	.	.	PUNCT
cajgh-29	159	1	the	the	DET
cajgh-29	159	2	majority	majority	NOUN
cajgh-29	159	3	of	of	ADP
cajgh-29	159	4	snps	snps	PROPN
cajgh-29	159	5	were	be	AUX
cajgh-29	159	6	in	in	ADP
cajgh-29	159	7	strong	strong	ADJ
cajgh-29	159	8	linkage	linkage	NOUN
cajgh-29	159	9	disequilibrium	disequilibrium	NOUN
cajgh-29	159	10	with	with	ADP
cajgh-29	159	11	one	one	NUM
cajgh-29	159	12	another	another	DET
cajgh-29	159	13	.	.	PUNCT
cajgh-29	160	1	nine	nine	NUM
cajgh-29	160	2	tagging	tag	VERB
cajgh-29	160	3	snps	snps	NOUN
cajgh-29	160	4	,	,	PUNCT
cajgh-29	160	5	including	include	VERB
cajgh-29	160	6	five	five	NUM
cajgh-29	160	7	missense	missense	NOUN
cajgh-29	160	8	snps	snps	NOUN
cajgh-29	160	9	,	,	PUNCT
cajgh-29	160	10	were	be	AUX
cajgh-29	160	11	selected	select	VERB
cajgh-29	160	12	to	to	PART
cajgh-29	160	13	predict	predict	VERB
cajgh-29	160	14	the	the	DET
cajgh-29	160	15	common	common	ADJ
cajgh-29	160	16	brca1	brca1	PROPN
cajgh-29	160	17	variants	variant	NOUN
cajgh-29	160	18	and	and	CCONJ
cajgh-29	160	19	haplotypes	haplotype	NOUN
cajgh-29	160	20	among	among	ADP
cajgh-29	160	21	the	the	DET
cajgh-29	160	22	non	non	ADJ
cajgh-29	160	23	–	–	ADJ
cajgh-29	160	24	african	african	ADJ
cajgh-29	160	25	american	american	ADJ
cajgh-29	160	26	groups	group	NOUN
cajgh-29	160	27	(	(	PUNCT
cajgh-29	160	28	five	five	NUM
cajgh-29	160	29	additional	additional	ADJ
cajgh-29	160	30	snps	snp	NOUN
cajgh-29	160	31	were	be	AUX
cajgh-29	160	32	required	require	VERB
cajgh-29	160	33	for	for	ADP
cajgh-29	160	34	african	african	ADJ
cajgh-29	160	35	americans	americans	PROPN
cajgh-29	160	36	)	)	PUNCT
cajgh-29	160	37	and	and	CCONJ
cajgh-29	160	38	genotyped	genotype	VERB
cajgh-29	160	39	in	in	ADP
cajgh-29	160	40	a	a	DET
cajgh-29	160	41	breast	breast	NOUN
cajgh-29	160	42	cancer	cancer	NOUN
cajgh-29	160	43	case	case	NOUN
cajgh-29	160	44	-	-	PUNCT
cajgh-29	160	45	control	control	NOUN
cajgh-29	160	46	study	study	NOUN
cajgh-29	160	47	nested	nest	VERB
cajgh-29	160	48	in	in	ADP
cajgh-29	160	49	the	the	DET
cajgh-29	160	50	multiethnic	multiethnic	ADJ
cajgh-29	160	51	cohort	cohort	NOUN
cajgh-29	160	52	study	study	NOUN
cajgh-29	160	53	(	(	PUNCT
cajgh-29	160	54	cases	case	NOUN
cajgh-29	160	55	,	,	PUNCT
cajgh-29	160	56	n	n	PROPN
cajgh-29	160	57	=	=	SYM
cajgh-29	160	58	1,715	1,715	NUM
cajgh-29	160	59	;	;	PUNCT
cajgh-29	160	60	controls	control	NOUN
cajgh-29	160	61	,	,	PUNCT
cajgh-29	160	62	n	n	PROPN
cajgh-29	160	63	=	=	NUM
cajgh-29	160	64	2,502	2,502	NUM
cajgh-29	160	65	)	)	PUNCT
cajgh-29	160	66	.	.	PUNCT
cajgh-29	161	1	in	in	ADP
cajgh-29	161	2	their	their	PRON
cajgh-29	161	3	another	another	DET
cajgh-29	161	4	study52	study52	NOUN
cajgh-29	161	5	freedman	freedman	PROPN
cajgh-29	161	6	ml	ml	PROPN
cajgh-29	161	7	et	et	PROPN
cajgh-29	161	8	al	al	PROPN
cajgh-29	161	9	observed	observe	VERB
cajgh-29	161	10	most	most	ADJ
cajgh-29	161	11	of	of	ADP
cajgh-29	161	12	the	the	DET
cajgh-29	161	13	common	common	ADJ
cajgh-29	161	14	brca2	brca2	NOUN
cajgh-29	161	15	haplotypes	haplotype	NOUN
cajgh-29	161	16	to	to	PART
cajgh-29	161	17	be	be	AUX
cajgh-29	161	18	shared	share	VERB
cajgh-29	161	19	among	among	ADP
cajgh-29	161	20	native	native	ADJ
cajgh-29	161	21	hawaiians	hawaiians	PROPN
cajgh-29	161	22	,	,	PUNCT
cajgh-29	161	23	japanese	japanese	PROPN
cajgh-29	161	24	,	,	PUNCT
cajgh-29	161	25	latinos	latinos	PROPN
cajgh-29	161	26	,	,	PUNCT
cajgh-29	161	27	and	and	CCONJ
cajgh-29	161	28	whites	white	NOUN
cajgh-29	161	29	;	;	PUNCT
cajgh-29	161	30	four	four	NUM
cajgh-29	161	31	of	of	ADP
cajgh-29	161	32	the	the	DET
cajgh-29	161	33	eight	eight	NUM
cajgh-29	161	34	common	common	ADJ
cajgh-29	161	35	haplotypes	haplotype	NOUN
cajgh-29	161	36	were	be	AUX
cajgh-29	161	37	found	find	VERB
cajgh-29	161	38	in	in	ADP
cajgh-29	161	39	at	at	ADV
cajgh-29	161	40	least	least	ADV
cajgh-29	161	41	three	three	NUM
cajgh-29	161	42	ethnic	ethnic	ADJ
cajgh-29	161	43	populations	population	NOUN
cajgh-29	161	44	and	and	CCONJ
cajgh-29	161	45	six	six	NUM
cajgh-29	161	46	of	of	ADP
cajgh-29	161	47	the	the	DET
cajgh-29	161	48	eight	eight	NUM
cajgh-29	161	49	were	be	AUX
cajgh-29	161	50	found	find	VERB
cajgh-29	161	51	in	in	ADP
cajgh-29	161	52	at	at	ADV
cajgh-29	161	53	least	least	ADV
cajgh-29	161	54	two	two	NUM
cajgh-29	161	55	groups	group	NOUN
cajgh-29	161	56	.	.	PUNCT
cajgh-29	162	1	authors	author	NOUN
cajgh-29	162	2	found	find	VERB
cajgh-29	162	3	no	no	DET
cajgh-29	162	4	evidence	evidence	NOUN
cajgh-29	162	5	for	for	ADP
cajgh-29	162	6	significant	significant	ADJ
cajgh-29	162	7	associations	association	NOUN
cajgh-29	162	8	between	between	ADP
cajgh-29	162	9	common	common	ADJ
cajgh-29	162	10	variation	variation	NOUN
cajgh-29	162	11	in	in	ADP
cajgh-29	162	12	brca1/2	brca1/2	NOUN
cajgh-29	162	13	and	and	CCONJ
cajgh-29	162	14	risk	risk	NOUN
cajgh-29	162	15	of	of	ADP
cajgh-29	162	16	breast	breast	NOUN
cajgh-29	162	17	cancer.51,52	cancer.51,52	NOUN
cajgh-29	162	18	in	in	ADP
cajgh-29	162	19	another	another	DET
cajgh-29	162	20	study	study	NOUN
cajgh-29	162	21	,	,	PUNCT
cajgh-29	162	22	cox	cox	PROPN
cajgh-29	162	23	dg	dg	PROPN
cajgh-29	162	24	et	et	PROPN
cajgh-29	162	25	al	al	PROPN
cajgh-29	162	26	reported	report	VERB
cajgh-29	162	27	a	a	DET
cajgh-29	162	28	modestly	modestly	ADV
cajgh-29	162	29	positive	positive	ADJ
cajgh-29	162	30	association	association	NOUN
cajgh-29	162	31	between	between	ADP
cajgh-29	162	32	a	a	DET
cajgh-29	162	33	brca1	brca1	NOUN
cajgh-29	162	34	haplotype	haplotype	NOUN
cajgh-29	162	35	and	and	CCONJ
cajgh-29	162	36	breast	breast	NOUN
cajgh-29	162	37	cancer	cancer	NOUN
cajgh-29	162	38	among	among	ADP
cajgh-29	162	39	white	white	ADJ
cajgh-29	162	40	women	woman	NOUN
cajgh-29	162	41	in	in	ADP
cajgh-29	162	42	the	the	DET
cajgh-29	162	43	nurses	nurse	NOUN
cajgh-29	162	44	’	'	PUNCT
cajgh-29	162	45	health	health	NOUN
cajgh-29	162	46	study	study	NOUN
cajgh-29	162	47	(	(	PUNCT
cajgh-29	162	48	or	or	CCONJ
cajgh-29	162	49	,	,	PUNCT
cajgh-29	162	50	1.18	1.18	NUM
cajgh-29	162	51	,	,	PUNCT
cajgh-29	162	52	95	95	NUM
cajgh-29	162	53	%	%	NOUN
cajgh-29	162	54	ci	ci	NOUN
cajgh-29	162	55	,	,	PUNCT
cajgh-29	162	56	1.02	1.02	NUM
cajgh-29	162	57	-	-	PUNCT
cajgh-29	162	58	1.37).53	1.37).53	NUM
cajgh-29	162	59	interestingly	interestingly	ADV
cajgh-29	162	60	,	,	PUNCT
cajgh-29	162	61	the	the	DET
cajgh-29	162	62	frequencies	frequency	NOUN
cajgh-29	162	63	of	of	ADP
cajgh-29	162	64	nearly	nearly	ADV
cajgh-29	162	65	all	all	PRON
cajgh-29	162	66	sequence	sequence	NOUN
cajgh-29	162	67	variants	variant	NOUN
cajgh-29	162	68	were	be	AUX
cajgh-29	162	69	significantly	significantly	ADV
cajgh-29	162	70	different	different	ADJ
cajgh-29	162	71	in	in	ADP
cajgh-29	162	72	caucasian	caucasian	ADJ
cajgh-29	162	73	and	and	CCONJ
cajgh-29	162	74	asian	asian	ADJ
cajgh-29	162	75	groups	group	NOUN
cajgh-29	162	76	among	among	ADP
cajgh-29	162	77	study	study	NOUN
cajgh-29	162	78	participants	participant	NOUN
cajgh-29	162	79	(	(	PUNCT
cajgh-29	162	80	table	table	NOUN
cajgh-29	162	81	2	2	NUM
cajgh-29	162	82	,	,	PUNCT
cajgh-29	162	83	3	3	NUM
cajgh-29	162	84	)	)	PUNCT
cajgh-29	162	85	.	.	PUNCT
cajgh-29	163	1	there	there	PRON
cajgh-29	163	2	was	be	VERB
cajgh-29	163	3	higher	high	ADJ
cajgh-29	163	4	prevalence	prevalence	NOUN
cajgh-29	163	5	of	of	ADP
cajgh-29	163	6	observed	observed	ADJ
cajgh-29	163	7	mutations	mutation	NOUN
cajgh-29	163	8	in	in	ADP
cajgh-29	163	9	caucasian	caucasian	ADJ
cajgh-29	163	10	cases	case	NOUN
cajgh-29	163	11	comparing	compare	VERB
cajgh-29	163	12	to	to	ADP
cajgh-29	163	13	asian	asian	ADJ
cajgh-29	163	14	breast	breast	NOUN
cajgh-29	163	15	cancer	cancer	NOUN
cajgh-29	163	16	cases	case	NOUN
cajgh-29	163	17	,	,	PUNCT
cajgh-29	163	18	(	(	PUNCT
cajgh-29	163	19	p<0.05	p<0.05	NOUN
cajgh-29	163	20	)	)	PUNCT
cajgh-29	163	21	and	and	CCONJ
cajgh-29	163	22	higher	high	ADJ
cajgh-29	163	23	frequency	frequency	NOUN
cajgh-29	163	24	of	of	ADP
cajgh-29	163	25	sequence	sequence	NOUN
cajgh-29	163	26	variants	variant	NOUN
cajgh-29	163	27	was	be	AUX
cajgh-29	163	28	observed	observe	VERB
cajgh-29	163	29	in	in	ADP
cajgh-29	163	30	control	control	NOUN
cajgh-29	163	31	group	group	NOUN
cajgh-29	163	32	in	in	ADP
cajgh-29	163	33	asians	asians	PROPN
cajgh-29	163	34	.	.	PUNCT
cajgh-29	164	1	further	further	ADJ
cajgh-29	164	2	studies	study	NOUN
cajgh-29	164	3	of	of	ADP
cajgh-29	164	4	large	large	ADJ
cajgh-29	164	5	numbers	number	NOUN
cajgh-29	164	6	of	of	ADP
cajgh-29	164	7	cases	case	NOUN
cajgh-29	164	8	may	may	AUX
cajgh-29	164	9	give	give	VERB
cajgh-29	164	10	a	a	DET
cajgh-29	164	11	more	more	ADV
cajgh-29	164	12	accurate	accurate	ADJ
cajgh-29	164	13	estimation	estimation	NOUN
cajgh-29	164	14	of	of	ADP
cajgh-29	164	15	prevalence	prevalence	NOUN
cajgh-29	164	16	and	and	CCONJ
cajgh-29	164	17	variations	variation	NOUN
cajgh-29	164	18	between	between	ADP
cajgh-29	164	19	asian	asian	ADJ
cajgh-29	164	20	and	and	CCONJ
cajgh-29	164	21	caucasian	caucasian	ADJ
cajgh-29	164	22	populations	population	NOUN
cajgh-29	164	23	in	in	ADP
cajgh-29	164	24	kazakhstan	kazakhstan	PROPN
cajgh-29	164	25	.	.	PUNCT
cajgh-29	165	1	the	the	DET
cajgh-29	165	2	vast	vast	ADJ
cajgh-29	165	3	majority	majority	NOUN
cajgh-29	165	4	of	of	ADP
cajgh-29	165	5	common	common	ADJ
cajgh-29	165	6	variation	variation	NOUN
cajgh-29	165	7	is	be	AUX
cajgh-29	165	8	shared	share	VERB
cajgh-29	165	9	between	between	ADP
cajgh-29	165	10	populations	population	NOUN
cajgh-29	165	11	;	;	PUNCT
cajgh-29	165	12	however	however	ADV
cajgh-29	165	13	,	,	PUNCT
cajgh-29	165	14	allele	allele	NOUN
cajgh-29	165	15	frequencies	frequency	NOUN
cajgh-29	165	16	are	be	AUX
cajgh-29	165	17	known	know	VERB
cajgh-29	165	18	to	to	PART
cajgh-29	165	19	vary	vary	VERB
cajgh-29	165	20	across	across	ADP
cajgh-29	165	21	populations54	populations54	NOUN
cajgh-29	165	22	and	and	CCONJ
cajgh-29	165	23	studies	study	NOUN
cajgh-29	165	24	conducted	conduct	VERB
cajgh-29	165	25	in	in	ADP
cajgh-29	165	26	a	a	DET
cajgh-29	165	27	multiethnic	multiethnic	ADJ
cajgh-29	165	28	population	population	NOUN
cajgh-29	165	29	may	may	AUX
cajgh-29	165	30	lend	lend	VERB
cajgh-29	165	31	insight	insight	NOUN
cajgh-29	165	32	into	into	ADP
cajgh-29	165	33	better	well	ADJ
cajgh-29	165	34	understanding	understand	VERB
cajgh-29	165	35	ethnic	ethnic	ADJ
cajgh-29	165	36	differences	difference	NOUN
cajgh-29	165	37	in	in	ADP
cajgh-29	165	38	breast	breast	NOUN
cajgh-29	165	39	cancer	cancer	NOUN
cajgh-29	165	40	risk.55	risk.55	PROPN
cajgh-29	165	41	although	although	SCONJ
cajgh-29	165	42	the	the	DET
cajgh-29	165	43	role	role	NOUN
cajgh-29	165	44	of	of	ADP
cajgh-29	165	45	common	common	ADJ
cajgh-29	165	46	variation	variation	NOUN
cajgh-29	165	47	in	in	ADP
cajgh-29	165	48	brca1	brca1	PROPN
cajgh-29	165	49	and	and	CCONJ
cajgh-29	165	50	sporadic	sporadic	ADJ
cajgh-29	165	51	breast	breast	NOUN
cajgh-29	165	52	cancer	cancer	NOUN
cajgh-29	165	53	risk	risk	NOUN
cajgh-29	165	54	has	have	AUX
cajgh-29	165	55	been	be	AUX
cajgh-29	165	56	thoroughly	thoroughly	ADV
cajgh-29	165	57	addressed	address	VERB
cajgh-29	165	58	,	,	PUNCT
cajgh-29	165	59	it	it	PRON
cajgh-29	165	60	remains	remain	VERB
cajgh-29	165	61	a	a	DET
cajgh-29	165	62	possibility	possibility	NOUN
cajgh-29	165	63	that	that	SCONJ
cajgh-29	165	64	this	this	DET
cajgh-29	165	65	locus	locus	NOUN
cajgh-29	165	66	may	may	AUX
cajgh-29	165	67	still	still	ADV
cajgh-29	165	68	prove	prove	VERB
cajgh-29	165	69	to	to	PART
cajgh-29	165	70	be	be	AUX
cajgh-29	165	71	involved	involve	VERB
cajgh-29	165	72	in	in	ADP
cajgh-29	165	73	breast	breast	NOUN
cajgh-29	165	74	cancer	cancer	NOUN
cajgh-29	165	75	risk	risk	NOUN
cajgh-29	165	76	.	.	PUNCT
cajgh-29	166	1	specifically	specifically	ADV
cajgh-29	166	2	,	,	PUNCT
cajgh-29	166	3	rare	rare	ADJ
cajgh-29	166	4	(	(	PUNCT
cajgh-29	166	5	<	<	X
cajgh-29	166	6	5	5	NUM
cajgh-29	166	7	%	%	NOUN
cajgh-29	166	8	)	)	PUNCT
cajgh-29	166	9	variants	variant	NOUN
cajgh-29	166	10	may	may	AUX
cajgh-29	166	11	contribute	contribute	VERB
cajgh-29	166	12	to	to	ADP
cajgh-29	166	13	disease	disease	NOUN
cajgh-29	166	14	;	;	PUNCT
cajgh-29	166	15	to	to	PART
cajgh-29	166	16	address	address	VERB
cajgh-29	166	17	this	this	DET
cajgh-29	166	18	hypothesis	hypothesis	NOUN
cajgh-29	166	19	,	,	PUNCT
cajgh-29	166	20	however	however	ADV
cajgh-29	166	21	,	,	PUNCT
cajgh-29	166	22	large	large	ADJ
cajgh-29	166	23	-	-	PUNCT
cajgh-29	166	24	scale	scale	NOUN
cajgh-29	166	25	resequencing	resequencing	NOUN
cajgh-29	166	26	efforts	effort	NOUN
cajgh-29	166	27	(	(	PUNCT
cajgh-29	166	28	to	to	PART
cajgh-29	166	29	discover	discover	VERB
cajgh-29	166	30	the	the	DET
cajgh-29	166	31	rare	rare	ADJ
cajgh-29	166	32	variants	variant	NOUN
cajgh-29	166	33	)	)	PUNCT
cajgh-29	166	34	and	and	CCONJ
cajgh-29	166	35	testing	testing	NOUN
cajgh-29	166	36	of	of	ADP
cajgh-29	166	37	these	these	DET
cajgh-29	166	38	variants	variant	NOUN
cajgh-29	166	39	in	in	ADP
cajgh-29	166	40	larger	large	ADJ
cajgh-29	166	41	cohorts	cohort	NOUN
cajgh-29	166	42	,	,	PUNCT
cajgh-29	166	43	such	such	ADJ
cajgh-29	166	44	as	as	ADP
cajgh-29	166	45	the	the	DET
cajgh-29	166	46	national	national	PROPN
cajgh-29	166	47	cancer	cancer	PROPN
cajgh-29	166	48	institute	institute	PROPN
cajgh-29	166	49	consortium	consortium	PROPN
cajgh-29	166	50	of	of	ADP
cajgh-29	166	51	cohorts,56	cohorts,56	NOUN
cajgh-29	166	52	will	will	AUX
cajgh-29	166	53	be	be	AUX
cajgh-29	166	54	required	require	VERB
cajgh-29	166	55	.	.	PUNCT
cajgh-29	167	1	another	another	DET
cajgh-29	167	2	possibility	possibility	NOUN
cajgh-29	167	3	is	be	AUX
cajgh-29	167	4	that	that	SCONJ
cajgh-29	167	5	a	a	DET
cajgh-29	167	6	sporadic	sporadic	ADJ
cajgh-29	167	7	breast	breast	NOUN
cajgh-29	167	8	cancer	cancer	NOUN
cajgh-29	167	9	is	be	AUX
cajgh-29	167	10	actually	actually	ADV
cajgh-29	167	11	a	a	DET
cajgh-29	167	12	collection	collection	NOUN
cajgh-29	167	13	of	of	ADP
cajgh-29	167	14	genetically	genetically	ADV
cajgh-29	167	15	distinct	distinct	ADJ
cajgh-29	167	16	subclasses	subclass	NOUN
cajgh-29	167	17	of	of	ADP
cajgh-29	167	18	breast	breast	NOUN
cajgh-29	167	19	cancer	cancer	NOUN
cajgh-29	167	20	.	.	PUNCT
cajgh-29	168	1	in	in	ADP
cajgh-29	168	2	this	this	DET
cajgh-29	168	3	scenario	scenario	NOUN
cajgh-29	168	4	,	,	PUNCT
cajgh-29	168	5	it	it	PRON
cajgh-29	168	6	would	would	AUX
cajgh-29	168	7	be	be	AUX
cajgh-29	168	8	unlikely	unlikely	ADJ
cajgh-29	168	9	that	that	SCONJ
cajgh-29	168	10	the	the	DET
cajgh-29	168	11	same	same	ADJ
cajgh-29	168	12	set	set	NOUN
cajgh-29	168	13	of	of	ADP
cajgh-29	168	14	underlying	underlie	VERB
cajgh-29	168	15	susceptibility	susceptibility	NOUN
cajgh-29	168	16	alleles	allele	NOUN
cajgh-29	168	17	occur	occur	VERB
cajgh-29	168	18	in	in	ADP
cajgh-29	168	19	all	all	DET
cajgh-29	168	20	breast	breast	NOUN
cajgh-29	168	21	cancer	cancer	NOUN
cajgh-29	168	22	cases	case	NOUN
cajgh-29	168	23	(	(	PUNCT
cajgh-29	168	24	i.e.	i.e.	X
cajgh-29	168	25	,	,	PUNCT
cajgh-29	168	26	the	the	DET
cajgh-29	168	27	genetic	genetic	ADJ
cajgh-29	168	28	architecture	architecture	NOUN
cajgh-29	168	29	of	of	ADP
cajgh-29	168	30	disease	disease	NOUN
cajgh-29	168	31	is	be	AUX
cajgh-29	168	32	not	not	PART
cajgh-29	168	33	genetically	genetically	ADV
cajgh-29	168	34	homogeneous	homogeneous	ADJ
cajgh-29	168	35	)	)	PUNCT
cajgh-29	168	36	.	.	PUNCT
cajgh-29	169	1	if	if	SCONJ
cajgh-29	169	2	these	these	DET
cajgh-29	169	3	subgroups	subgroup	NOUN
cajgh-29	169	4	are	be	AUX
cajgh-29	169	5	not	not	PART
cajgh-29	169	6	recognized	recognize	VERB
cajgh-29	169	7	and	and	CCONJ
cajgh-29	169	8	analyzed	analyze	VERB
cajgh-29	169	9	separately	separately	ADV
cajgh-29	169	10	,	,	PUNCT
cajgh-29	169	11	then	then	ADV
cajgh-29	169	12	the	the	DET
cajgh-29	169	13	power	power	NOUN
cajgh-29	169	14	to	to	PART
cajgh-29	169	15	detect	detect	VERB
cajgh-29	169	16	them	they	PRON
cajgh-29	169	17	will	will	AUX
cajgh-29	169	18	be	be	AUX
cajgh-29	169	19	diminished	diminish	VERB
cajgh-29	169	20	.	.	PUNCT
cajgh-29	170	1	at	at	ADP
cajgh-29	170	2	the	the	DET
cajgh-29	170	3	histologic	histologic	ADJ
cajgh-29	170	4	and	and	CCONJ
cajgh-29	170	5	molecular	molecular	ADJ
cajgh-29	170	6	levels	level	NOUN
cajgh-29	170	7	,	,	PUNCT
cajgh-29	170	8	breast	breast	NOUN
cajgh-29	170	9	tumors	tumor	NOUN
cajgh-29	170	10	have	have	VERB
cajgh-29	170	11	different	different	ADJ
cajgh-29	170	12	characteristics	characteristic	NOUN
cajgh-29	170	13	;	;	PUNCT
cajgh-29	170	14	subsets	subset	NOUN
cajgh-29	170	15	of	of	ADP
cajgh-29	170	16	breast	breast	NOUN
cajgh-29	170	17	tumors	tumor	NOUN
cajgh-29	170	18	as	as	SCONJ
cajgh-29	170	19	defined	define	VERB
cajgh-29	170	20	by	by	ADP
cajgh-29	170	21	immunohistochemistry	immunohistochemistry	NOUN
cajgh-29	170	22	[	[	X
cajgh-29	170	23	e.g.	e.g.	ADV
cajgh-29	170	24	,	,	PUNCT
cajgh-29	170	25	estrogen	estrogen	NOUN
cajgh-29	170	26	-	-	PUNCT
cajgh-29	170	27	receptor	receptor	NOUN
cajgh-29	170	28	(	(	PUNCT
cajgh-29	170	29	+	+	NOUN
cajgh-29	170	30	/-	/-	PUNCT
cajgh-29	170	31	)	)	PUNCT
cajgh-29	170	32	and	and	CCONJ
cajgh-29	170	33	her2	her2	PROPN
cajgh-29	170	34	/	/	SYM
cajgh-29	170	35	neu(+/-	neu(+/-	PROPN
cajgh-29	170	36	)	)	PUNCT
cajgh-29	170	37	]	]	PUNCT
cajgh-29	170	38	often	often	ADV
cajgh-29	170	39	display	display	VERB
cajgh-29	170	40	different	different	ADJ
cajgh-29	170	41	biological	biological	ADJ
cajgh-29	170	42	behaviors	behavior	NOUN
cajgh-29	170	43	,	,	PUNCT
cajgh-29	170	44	such	such	ADJ
cajgh-29	170	45	as	as	ADP
cajgh-29	170	46	time	time	NOUN
cajgh-29	170	47	to	to	ADP
cajgh-29	170	48	disease	disease	NOUN
cajgh-29	170	49	progression	progression	NOUN
cajgh-29	170	50	and	and	CCONJ
cajgh-29	170	51	response	response	NOUN
cajgh-29	170	52	to	to	ADP
cajgh-29	170	53	therapy	therapy	NOUN
cajgh-29	170	54	,	,	PUNCT
cajgh-29	170	55	which	which	PRON
cajgh-29	170	56	may	may	AUX
cajgh-29	170	57	reflect	reflect	VERB
cajgh-29	170	58	different	different	ADJ
cajgh-29	170	59	genetic	genetic	ADJ
cajgh-29	170	60	origins	origin	NOUN
cajgh-29	170	61	.	.	PUNCT
cajgh-29	171	1	studies	study	NOUN
cajgh-29	171	2	have	have	AUX
cajgh-29	171	3	shown	show	VERB
cajgh-29	171	4	that	that	SCONJ
cajgh-29	171	5	breast	breast	NOUN
cajgh-29	171	6	tumors	tumor	NOUN
cajgh-29	171	7	of	of	ADP
cajgh-29	171	8	women	woman	NOUN
cajgh-29	171	9	with	with	ADP
cajgh-29	171	10	hereditary	hereditary	ADJ
cajgh-29	171	11	breast	breast	NOUN
cajgh-29	171	12	cancer	cancer	NOUN
cajgh-29	171	13	with	with	ADP
cajgh-29	171	14	mutations	mutation	NOUN
cajgh-29	171	15	in	in	ADP
cajgh-29	171	16	brca1	brca1	PROPN
cajgh-29	171	17	and	and	CCONJ
cajgh-29	171	18	a	a	DET
cajgh-29	171	19	subset	subset	NOUN
cajgh-29	171	20	of	of	ADP
cajgh-29	171	21	women	woman	NOUN
cajgh-29	171	22	with	with	ADP
cajgh-29	171	23	sporadic	sporadic	ADJ
cajgh-29	171	24	disease	disease	NOUN
cajgh-29	171	25	(	(	PUNCT
cajgh-29	171	26	f25	f25	PROPN
cajgh-29	171	27	%	%	NOUN
cajgh-29	171	28	)	)	PUNCT
cajgh-29	171	29	share	share	VERB
cajgh-29	171	30	similar	similar	ADJ
cajgh-29	171	31	traits	trait	NOUN
cajgh-29	171	32	,	,	PUNCT
cajgh-29	171	33	including	include	VERB
cajgh-29	171	34	a	a	DET
cajgh-29	171	35	basal	basal	ADJ
cajgh-29	171	36	cell	cell	NOUN
cajgh-29	171	37	histology	histology	NOUN
cajgh-29	171	38	,	,	PUNCT
cajgh-29	171	39	higher	high	ADJ
cajgh-29	171	40	grade	grade	NOUN
cajgh-29	171	41	tumors	tumor	NOUN
cajgh-29	171	42	,	,	PUNCT
cajgh-29	171	43	cytokeratins	cytokeratin	VERB
cajgh-29	171	44	5/6	5/6	NUM
cajgh-29	171	45	,	,	PUNCT
cajgh-29	171	46	and	and	CCONJ
cajgh-29	171	47	estrogen	estrogen	NOUN
cajgh-29	171	48	receptor	receptor	NOUN
cajgh-29	171	49	negativity	negativity	NOUN
cajgh-29	171	50	,	,	PUNCT
cajgh-29	171	51	suggesting	suggest	VERB
cajgh-29	171	52	they	they	PRON
cajgh-29	171	53	may	may	AUX
cajgh-29	171	54	have	have	VERB
cajgh-29	171	55	a	a	DET
cajgh-29	171	56	similar	similar	ADJ
cajgh-29	171	57	etiology.57	etiology.57	NOUN
cajgh-29	171	58	-	-	PUNCT
cajgh-29	171	59	59	59	NUM
cajgh-29	171	60	the	the	DET
cajgh-29	171	61	ability	ability	NOUN
cajgh-29	171	62	to	to	PART
cajgh-29	171	63	stratify	stratify	VERB
cajgh-29	171	64	breast	breast	NOUN
cajgh-29	171	65	cancer	cancer	NOUN
cajgh-29	171	66	cases	case	NOUN
cajgh-29	171	67	by	by	ADP
cajgh-29	171	68	expression	expression	NOUN
cajgh-29	171	69	profiling	profiling	NOUN
cajgh-29	171	70	,	,	PUNCT
cajgh-29	171	71	immunohistochemistry	immunohistochemistry	NOUN
cajgh-29	171	72	,	,	PUNCT
cajgh-29	171	73	methylation	methylation	NOUN
cajgh-29	171	74	patterns	pattern	NOUN
cajgh-29	171	75	,	,	PUNCT
cajgh-29	171	76	and/or	and/or	CCONJ
cajgh-29	171	77	clinical	clinical	ADJ
cajgh-29	171	78	variables	variable	NOUN
cajgh-29	171	79	may	may	AUX
cajgh-29	171	80	facilitate	facilitate	VERB
cajgh-29	171	81	the	the	DET
cajgh-29	171	82	identification	identification	NOUN
cajgh-29	171	83	of	of	ADP
cajgh-29	171	84	more	more	ADV
cajgh-29	171	85	genetically	genetically	ADV
cajgh-29	171	86	homogeneous	homogeneous	ADJ
cajgh-29	171	87	subsets	subset	NOUN
cajgh-29	171	88	of	of	ADP
cajgh-29	171	89	cancer	cancer	NOUN
cajgh-29	171	90	cases	case	NOUN
cajgh-29	171	91	,	,	PUNCT
cajgh-29	171	92	and	and	CCONJ
cajgh-29	171	93	therefore	therefore	ADV
cajgh-29	171	94	may	may	AUX
cajgh-29	171	95	help	help	VERB
cajgh-29	171	96	to	to	PART
cajgh-29	171	97	identify	identify	VERB
cajgh-29	171	98	causal	causal	ADJ
cajgh-29	171	99	variants	variant	NOUN
cajgh-29	171	100	underlying	underlie	VERB
cajgh-29	171	101	specific	specific	ADJ
cajgh-29	171	102	breast	breast	NOUN
cajgh-29	171	103	cancer	cancer	NOUN
cajgh-29	171	104	phenotypes	phenotype	NOUN
cajgh-29	171	105	.	.	PUNCT
cajgh-29	172	1	there	there	PRON
cajgh-29	172	2	are	be	VERB
cajgh-29	172	3	several	several	ADJ
cajgh-29	172	4	limitations	limitation	NOUN
cajgh-29	172	5	to	to	ADP
cajgh-29	172	6	this	this	DET
cajgh-29	172	7	study	study	NOUN
cajgh-29	172	8	.	.	PUNCT
cajgh-29	173	1	we	we	PRON
cajgh-29	173	2	did	do	AUX
cajgh-29	173	3	not	not	PART
cajgh-29	173	4	include	include	VERB
cajgh-29	173	5	results	result	NOUN
cajgh-29	173	6	of	of	ADP
cajgh-29	173	7	screening	screen	VERB
cajgh-29	173	8	entire	entire	ADJ
cajgh-29	173	9	exons	exon	NOUN
cajgh-29	173	10	of	of	ADP
cajgh-29	173	11	brca1	brca1	PROPN
cajgh-29	173	12	and	and	CCONJ
cajgh-29	173	13	brca2	brca2	NOUN
cajgh-29	173	14	genes	gene	NOUN
cajgh-29	173	15	in	in	ADP
cajgh-29	173	16	families	family	NOUN
cajgh-29	173	17	with	with	ADP
cajgh-29	173	18	breast	breast	NOUN
cajgh-29	173	19	/	/	SYM
cajgh-29	173	20	ovarian	ovarian	ADJ
cajgh-29	173	21	cancer	cancer	NOUN
cajgh-29	173	22	members	member	NOUN
cajgh-29	173	23	.	.	PUNCT
cajgh-29	174	1	this	this	DET
cajgh-29	174	2	study	study	NOUN
cajgh-29	174	3	is	be	AUX
cajgh-29	174	4	still	still	ADV
cajgh-29	174	5	ongoing	ongoing	ADJ
cajgh-29	174	6	because	because	SCONJ
cajgh-29	174	7	family	family	NOUN
cajgh-29	174	8	bc	bc	PROPN
cajgh-29	174	9	cases	case	NOUN
cajgh-29	174	10	in	in	ADP
cajgh-29	174	11	kazakhstan	kazakhstan	PROPN
cajgh-29	174	12	are	be	AUX
cajgh-29	174	13	sparse	sparse	ADJ
cajgh-29	174	14	.	.	PUNCT
cajgh-29	175	1	further	further	ADJ
cajgh-29	175	2	evaluation	evaluation	NOUN
cajgh-29	175	3	is	be	AUX
cajgh-29	175	4	needed	need	VERB
cajgh-29	175	5	to	to	PART
cajgh-29	175	6	clarify	clarify	VERB
cajgh-29	175	7	the	the	DET
cajgh-29	175	8	relationship	relationship	NOUN
cajgh-29	175	9	between	between	ADP
cajgh-29	175	10	frequency	frequency	NOUN
cajgh-29	175	11	of	of	ADP
cajgh-29	175	12	sequence	sequence	NOUN
cajgh-29	175	13	alterations	alteration	NOUN
cajgh-29	175	14	in	in	ADP
cajgh-29	175	15	brca1/2	brca1/2	ADJ
cajgh-29	175	16	genes	gene	NOUN
cajgh-29	175	17	and	and	CCONJ
cajgh-29	175	18	breast	breast	NOUN
cajgh-29	175	19	cancer	cancer	NOUN
cajgh-29	175	20	risks	risk	NOUN
cajgh-29	175	21	in	in	ADP
cajgh-29	175	22	kazakhstan	kazakhstan	PROPN
cajgh-29	175	23	women	woman	NOUN
cajgh-29	175	24	in	in	ADP
cajgh-29	175	25	family	family	NOUN
cajgh-29	175	26	-	-	PUNCT
cajgh-29	175	27	based	base	VERB
cajgh-29	175	28	and	and	CCONJ
cajgh-29	175	29	genetically	genetically	ADV
cajgh-29	175	30	homogeneous	homogeneous	ADJ
cajgh-29	175	31	cases	case	NOUN
cajgh-29	175	32	.	.	PUNCT
cajgh-29	176	1	in	in	ADP
cajgh-29	176	2	conclusion	conclusion	NOUN
cajgh-29	176	3	,	,	PUNCT
cajgh-29	176	4	156	156	NUM
cajgh-29	176	5	kazakhstan	kazakhstan	PROPN
cajgh-29	176	6	patients	patient	NOUN
cajgh-29	176	7	with	with	ADP
cajgh-29	176	8	sporadic	sporadic	ADJ
cajgh-29	176	9	breast	breast	NOUN
cajgh-29	176	10	cancer	cancer	NOUN
cajgh-29	176	11	were	be	AUX
cajgh-29	176	12	analyzed	analyze	VERB
cajgh-29	176	13	for	for	ADP
cajgh-29	176	14	mutations	mutation	NOUN
cajgh-29	176	15	throughout	throughout	ADP
cajgh-29	176	16	the	the	DET
cajgh-29	176	17	entire	entire	ADJ
cajgh-29	176	18	coding	code	VERB
cajgh-29	176	19	regions	region	NOUN
cajgh-29	176	20	of	of	ADP
cajgh-29	176	21	the	the	DET
cajgh-29	176	22	brca1	brca1	NOUN
cajgh-29	176	23	and	and	CCONJ
cajgh-29	176	24	brca2	brca2	NOUN
cajgh-29	176	25	genes	gene	NOUN
cajgh-29	176	26	,	,	PUNCT
cajgh-29	176	27	using	use	VERB
cajgh-29	176	28	direct	direct	ADJ
cajgh-29	176	29	sequencing	sequencing	NOUN
cajgh-29	176	30	.	.	PUNCT
cajgh-29	177	1	the	the	DET
cajgh-29	177	2	present	present	ADJ
cajgh-29	177	3	investigation	investigation	NOUN
cajgh-29	177	4	revealed	reveal	VERB
cajgh-29	177	5	22	22	NUM
cajgh-29	177	6	different	different	ADJ
cajgh-29	177	7	sequence	sequence	NOUN
cajgh-29	177	8	variants	variant	NOUN
cajgh-29	177	9	.	.	PUNCT
cajgh-29	178	1	although	although	SCONJ
cajgh-29	178	2	we	we	PRON
cajgh-29	178	3	found	find	VERB
cajgh-29	178	4	none	none	NOUN
cajgh-29	178	5	of	of	ADP
cajgh-29	178	6	pathological	pathological	ADJ
cajgh-29	178	7	deleterious	deleterious	ADJ
cajgh-29	178	8	mutations	mutation	NOUN
cajgh-29	178	9	in	in	ADP
cajgh-29	178	10	brca1/2	brca1/2	ADJ
cajgh-29	178	11	genes	gene	NOUN
cajgh-29	178	12	,	,	PUNCT
cajgh-29	178	13	we	we	PRON
cajgh-29	178	14	believe	believe	VERB
cajgh-29	178	15	that	that	SCONJ
cajgh-29	178	16	the	the	DET
cajgh-29	178	17	present	present	ADJ
cajgh-29	178	18	study	study	NOUN
cajgh-29	178	19	allows	allow	VERB
cajgh-29	178	20	a	a	DET
cajgh-29	178	21	better	well	ADJ
cajgh-29	178	22	evaluation	evaluation	NOUN
cajgh-29	178	23	of	of	ADP
cajgh-29	178	24	the	the	DET
cajgh-29	178	25	need	need	NOUN
cajgh-29	178	26	for	for	ADP
cajgh-29	178	27	the	the	DET
cajgh-29	178	28	genetic	genetic	ADJ
cajgh-29	178	29	screening	screening	NOUN
cajgh-29	178	30	of	of	ADP
cajgh-29	178	31	brca	brca	PROPN
cajgh-29	178	32	mutations	mutation	NOUN
cajgh-29	178	33	in	in	ADP
cajgh-29	178	34	sporadic	sporadic	ADJ
cajgh-29	178	35	breast	breast	NOUN
cajgh-29	178	36	cancer	cancer	NOUN
cajgh-29	178	37	patients	patient	NOUN
cajgh-29	178	38	in	in	ADP
cajgh-29	178	39	kazakhstan	kazakhstan	PROPN
cajgh-29	178	40	.	.	PUNCT
cajgh-29	179	1	however	however	ADV
cajgh-29	179	2	,	,	PUNCT
cajgh-29	179	3	large	large	ADJ
cajgh-29	179	4	population	population	NOUN
cajgh-29	179	5	-	-	PUNCT
cajgh-29	179	6	based	base	VERB
cajgh-29	179	7	screening	screening	NOUN
cajgh-29	179	8	studies	study	NOUN
cajgh-29	179	9	are	be	AUX
cajgh-29	179	10	needed	need	VERB
cajgh-29	179	11	to	to	PART
cajgh-29	179	12	establish	establish	VERB
cajgh-29	179	13	the	the	DET
cajgh-29	179	14	frequency	frequency	NOUN
cajgh-29	179	15	,	,	PUNCT
cajgh-29	179	16	penetrance	penetrance	NOUN
cajgh-29	179	17	,	,	PUNCT
cajgh-29	179	18	and	and	CCONJ
cajgh-29	179	19	significance	significance	NOUN
cajgh-29	179	20	of	of	ADP
cajgh-29	179	21	the	the	DET
cajgh-29	179	22	broad	broad	ADJ
cajgh-29	179	23	spectrum	spectrum	NOUN
cajgh-29	179	24	of	of	ADP
cajgh-29	179	25	variations	variation	NOUN
cajgh-29	179	26	in	in	ADP
cajgh-29	179	27	the	the	DET
cajgh-29	179	28	sequence	sequence	NOUN
cajgh-29	179	29	of	of	ADP
cajgh-29	179	30	brca1/2	brca1/2	ADJ
cajgh-29	179	31	genes	gene	NOUN
cajgh-29	179	32	in	in	ADP
cajgh-29	179	33	kazakhstan	kazakhstan	PROPN
cajgh-29	179	34	population	population	NOUN
cajgh-29	179	35	.	.	PUNCT
cajgh-29	180	1	it	it	PRON
cajgh-29	180	2	is	be	AUX
cajgh-29	180	3	hoped	hope	VERB
cajgh-29	180	4	that	that	SCONJ
cajgh-29	180	5	similar	similar	ADJ
cajgh-29	180	6	mutation	mutation	NOUN
cajgh-29	180	7	surveys	survey	NOUN
cajgh-29	180	8	in	in	ADP
cajgh-29	180	9	other	other	ADJ
cajgh-29	180	10	central	central	ADJ
cajgh-29	180	11	asian	asian	ADJ
cajgh-29	180	12	countries	country	NOUN
cajgh-29	180	13	will	will	AUX
cajgh-29	180	14	be	be	AUX
cajgh-29	180	15	completed	complete	VERB
cajgh-29	180	16	so	so	SCONJ
cajgh-29	180	17	that	that	SCONJ
cajgh-29	180	18	information	information	NOUN
cajgh-29	180	19	can	can	AUX
cajgh-29	180	20	be	be	AUX
cajgh-29	180	21	compared	compare	VERB
cajgh-29	180	22	and	and	CCONJ
cajgh-29	180	23	the	the	DET
cajgh-29	180	24	most	most	ADV
cajgh-29	180	25	common	common	ADJ
cajgh-29	180	26	mutations	mutation	NOUN
cajgh-29	180	27	identified	identify	VERB
cajgh-29	180	28	.	.	PUNCT
cajgh-29	181	1	acknowledgements	acknowledgement	NOUN
cajgh-29	181	2	we	we	PRON
cajgh-29	181	3	are	be	AUX
cajgh-29	181	4	thankful	thankful	ADJ
cajgh-29	181	5	to	to	ADP
cajgh-29	181	6	all	all	DET
cajgh-29	181	7	patients	patient	NOUN
cajgh-29	181	8	and	and	CCONJ
cajgh-29	181	9	healthy	healthy	ADJ
cajgh-29	181	10	women	woman	NOUN
cajgh-29	181	11	who	who	PRON
cajgh-29	181	12	took	take	VERB
cajgh-29	181	13	part	part	NOUN
cajgh-29	181	14	in	in	ADP
cajgh-29	181	15	this	this	DET
cajgh-29	181	16	study	study	NOUN
cajgh-29	181	17	and	and	CCONJ
cajgh-29	181	18	to	to	ADP
cajgh-29	181	19	the	the	DET
cajgh-29	181	20	staff	staff	NOUN
cajgh-29	181	21	of	of	ADP
cajgh-29	181	22	semey	semey	PROPN
cajgh-29	181	23	and	and	CCONJ
cajgh-29	181	24	astana	astana	PROPN
cajgh-29	181	25	oncological	oncological	ADJ
cajgh-29	181	26	centers	center	NOUN
cajgh-29	181	27	who	who	PRON
cajgh-29	181	28	helped	help	VERB
cajgh-29	181	29	to	to	PART
cajgh-29	181	30	collect	collect	VERB
cajgh-29	181	31	samples	sample	NOUN
cajgh-29	181	32	.	.	PUNCT
cajgh-29	182	1	this	this	DET
cajgh-29	182	2	work	work	NOUN
cajgh-29	182	3	was	be	AUX
cajgh-29	182	4	supported	support	VERB
cajgh-29	182	5	by	by	ADP
cajgh-29	182	6	grant	grant	NOUN
cajgh-29	182	7	-	-	PUNCT
cajgh-29	182	8	in	in	ADP
cajgh-29	182	9	-	-	PUNCT
cajgh-29	182	10	aid	aid	NOUN
cajgh-29	182	11	from	from	ADP
cajgh-29	182	12	the	the	DET
cajgh-29	182	13	kazakhstan	kazakhstan	PROPN
cajgh-29	182	14	ministry	ministry	PROPN
cajgh-29	182	15	of	of	ADP
cajgh-29	182	16	education	education	PROPN
cajgh-29	182	17	and	and	CCONJ
cajgh-29	182	18	science	science	NOUN
cajgh-29	182	19	.	.	PUNCT
cajgh-29	183	1	references	reference	NOUN
cajgh-29	183	2	1	1	NUM
cajgh-29	183	3	.	.	PUNCT
cajgh-29	183	4	parkin	parkin	PROPN
cajgh-29	183	5	dm	dm	PROPN
cajgh-29	183	6	,	,	PUNCT
cajgh-29	183	7	bray	bray	PROPN
cajgh-29	183	8	f	f	PROPN
cajgh-29	183	9	,	,	PUNCT
cajgh-29	183	10	ferlay	ferlay	PROPN
cajgh-29	183	11	j	j	PROPN
cajgh-29	183	12	,	,	PUNCT
cajgh-29	183	13	pisani	pisani	PROPN
cajgh-29	184	1	p.	p.	NOUN
cajgh-29	184	2	global	global	ADJ
cajgh-29	184	3	cancer	cancer	NOUN
cajgh-29	184	4	statistics	statistic	NOUN
cajgh-29	184	5	,	,	PUNCT
cajgh-29	184	6	2002	2002	NUM
cajgh-29	184	7	.	.	PUNCT
cajgh-29	185	1	ca	can	AUX
cajgh-29	185	2	cancer	cancer	PROPN
cajgh-29	185	3	j	j	PROPN
cajgh-29	185	4	clin	clin	PROPN
cajgh-29	185	5	.	.	PUNCT
cajgh-29	186	1	2005	2005	NUM
cajgh-29	186	2	;	;	PUNCT
cajgh-29	186	3	55	55	NUM
cajgh-29	186	4	(	(	PUNCT
cajgh-29	186	5	2	2	NUM
cajgh-29	186	6	):	):	PUNCT
cajgh-29	186	7	74–108	74–108	NUM
cajgh-29	186	8	.	.	PUNCT
cajgh-29	186	9	2	2	NUM
cajgh-29	186	10	.	.	X
cajgh-29	186	11	official	official	ADJ
cajgh-29	186	12	site	site	NOUN
cajgh-29	186	13	of	of	ADP
cajgh-29	186	14	ministry	ministry	PROPN
cajgh-29	186	15	of	of	ADP
cajgh-29	186	16	healthcare	healthcare	PROPN
cajgh-29	186	17	,	,	PUNCT
cajgh-29	186	18	republic	republic	NOUN
cajgh-29	186	19	of	of	ADP
cajgh-29	186	20	kazakhstan	kazakhstan	PROPN
cajgh-29	186	21	,	,	PUNCT
cajgh-29	186	22	http://www.minzdrav.kz	http://www.minzdrav.kz	X
cajgh-29	186	23	.	.	PUNCT
cajgh-29	187	1	3	3	X
cajgh-29	187	2	.	.	X
cajgh-29	187	3	martin	martin	PROPN
cajgh-29	187	4	am	am	PROPN
cajgh-29	187	5	,	,	PUNCT
cajgh-29	187	6	blackwood	blackwood	PROPN
cajgh-29	187	7	ma	ma	PROPN
cajgh-29	187	8	,	,	PUNCT
cajgh-29	187	9	antin	antin	PROPN
cajgh-29	187	10	-	-	PUNCT
cajgh-29	187	11	ozerkis	ozerkis	PROPN
cajgh-29	187	12	d	d	NOUN
cajgh-29	187	13	,	,	PUNCT
cajgh-29	187	14	et	et	PROPN
cajgh-29	187	15	al	al	PROPN
cajgh-29	187	16	.	.	PROPN
cajgh-29	188	1	germline	germline	NOUN
cajgh-29	188	2	mutations	mutation	NOUN
cajgh-29	188	3	in	in	ADP
cajgh-29	188	4	brca1	brca1	PROPN
cajgh-29	188	5	and	and	CCONJ
cajgh-29	188	6	brca2	brca2	PROPN
cajgh-29	188	7	in	in	ADP
cajgh-29	188	8	breast	breast	NOUN
cajgh-29	188	9	-	-	PUNCT
cajgh-29	188	10	ovarian	ovarian	ADJ
cajgh-29	188	11	families	family	NOUN
cajgh-29	188	12	from	from	ADP
cajgh-29	188	13	a	a	DET
cajgh-29	188	14	breast	breast	NOUN
cajgh-29	188	15	cancer	cancer	NOUN
cajgh-29	188	16	risk	risk	NOUN
cajgh-29	188	17	evaluation	evaluation	NOUN
cajgh-29	188	18	clinic	clinic	NOUN
cajgh-29	188	19	.	.	PUNCT
cajgh-29	189	1	j	j	PROPN
cajgh-29	189	2	clin	clin	PROPN
cajgh-29	189	3	oncol	oncol	PROPN
cajgh-29	189	4	.	.	PUNCT
cajgh-29	190	1	2001	2001	NUM
cajgh-29	190	2	;	;	PUNCT
cajgh-29	190	3	19:2247–2253	19:2247–2253	NUM
cajgh-29	190	4	.	.	NOUN
cajgh-29	191	1	4	4	NUM
cajgh-29	191	2	.	.	X
cajgh-29	191	3	hall	hall	PROPN
cajgh-29	191	4	jm	jm	PROPN
cajgh-29	191	5	,	,	PUNCT
cajgh-29	191	6	lee	lee	PROPN
cajgh-29	191	7	mk	mk	PROPN
cajgh-29	191	8	,	,	PUNCT
cajgh-29	191	9	newman	newman	PROPN
cajgh-29	191	10	b	b	PROPN
cajgh-29	191	11	,	,	PUNCT
cajgh-29	191	12	morrow	morrow	PROPN
cajgh-29	191	13	je	je	PROPN
cajgh-29	191	14	,	,	PUNCT
cajgh-29	191	15	anderson	anderson	PROPN
cajgh-29	191	16	la	la	PROPN
cajgh-29	191	17	,	,	PUNCT
cajgh-29	191	18	huey	huey	PROPN
cajgh-29	191	19	b	b	PROPN
cajgh-29	191	20	,	,	PUNCT
cajgh-29	191	21	king	king	PROPN
cajgh-29	191	22	mc	mc	PROPN
cajgh-29	191	23	.	.	PROPN
cajgh-29	192	1	linkage	linkage	NOUN
cajgh-29	192	2	of	of	ADP
cajgh-29	192	3	early	early	ADJ
cajgh-29	192	4	-	-	PUNCT
cajgh-29	192	5	onset	onset	NOUN
cajgh-29	192	6	familial	familial	ADJ
cajgh-29	192	7	breast	breast	NOUN
cajgh-29	192	8	cancer	cancer	NOUN
cajgh-29	192	9	to	to	ADP
cajgh-29	192	10	chromosome17q21	chromosome17q21	PROPN
cajgh-29	192	11	.	.	PUNCT
cajgh-29	193	1	science	science	NOUN
cajgh-29	193	2	.	.	PUNCT
cajgh-29	194	1	1990	1990	NUM
cajgh-29	194	2	;	;	PUNCT
cajgh-29	194	3	250:1684	250:1684	NUM
cajgh-29	194	4	-	-	SYM
cajgh-29	194	5	1689	1689	NUM
cajgh-29	194	6	.	.	PUNCT
cajgh-29	195	1	5	5	NUM
cajgh-29	195	2	.	.	X
cajgh-29	195	3	wooster	wooster	PROPN
cajgh-29	195	4	r	r	PROPN
cajgh-29	195	5	,	,	PUNCT
cajgh-29	195	6	neuhausen	neuhausen	NOUN
cajgh-29	195	7	sl	sl	NOUN
cajgh-29	195	8	,	,	PUNCT
cajgh-29	195	9	mangion	mangion	NOUN
cajgh-29	195	10	j	j	PROPN
cajgh-29	195	11	,	,	PUNCT
cajgh-29	195	12	quirk	quirk	PROPN
cajgh-29	195	13	y	y	PROPN
cajgh-29	195	14	,	,	PUNCT
cajgh-29	195	15	ford	ford	PROPN
cajgh-29	195	16	d	d	PROPN
cajgh-29	195	17	,	,	PUNCT
cajgh-29	195	18	collins	collins	PROPN
cajgh-29	195	19	n	n	PRON
cajgh-29	195	20	,	,	PUNCT
cajgh-29	195	21	nguyen	nguyen	PROPN
cajgh-29	195	22	k	k	NOUN
cajgh-29	195	23	,	,	PUNCT
cajgh-29	195	24	seal	seal	NOUN
cajgh-29	195	25	s	s	PROPN
cajgh-29	195	26	,	,	PUNCT
cajgh-29	195	27	tran	tran	PROPN
cajgh-29	195	28	t	t	PROPN
cajgh-29	195	29	,	,	PUNCT
cajgh-29	195	30	averill	averill	PROPN
cajgh-29	195	31	d.	d.	PROPN
cajgh-29	195	32	localization	localization	NOUN
cajgh-29	195	33	of	of	ADP
cajgh-29	195	34	a	a	DET
cajgh-29	195	35	breast	breast	NOUN
cajgh-29	195	36	cancer	cancer	NOUN
cajgh-29	195	37	susceptibility	susceptibility	NOUN
cajgh-29	195	38	gene	gene	NOUN
cajgh-29	195	39	,	,	PUNCT
cajgh-29	195	40	brca2	brca2	PROPN
cajgh-29	195	41	,	,	PUNCT
cajgh-29	195	42	to	to	PART
cajgh-29	195	43	chromosome	chromosome	VERB
cajgh-29	195	44	13q12	13q12	NUM
cajgh-29	195	45	-	-	SYM
cajgh-29	195	46	13	13	NUM
cajgh-29	195	47	.	.	PUNCT
cajgh-29	196	1	science	science	NOUN
cajgh-29	196	2	.	.	PUNCT
cajgh-29	196	3	1994	1994	NUM
cajgh-29	196	4	;	;	PUNCT
cajgh-29	196	5	265:2088	265:2088	NUM
cajgh-29	196	6	-	-	NOUN
cajgh-29	196	7	2090	2090	NUM
cajgh-29	196	8	.	.	PUNCT
cajgh-29	197	1	6	6	NUM
cajgh-29	197	2	.	.	X
cajgh-29	197	3	scully	scully	PROPN
cajgh-29	197	4	r	r	PROPN
cajgh-29	197	5	,	,	PUNCT
cajgh-29	197	6	livingston	livingston	PROPN
cajgh-29	197	7	dm	dm	PROPN
cajgh-29	197	8	.	.	PUNCT
cajgh-29	198	1	in	in	ADP
cajgh-29	198	2	search	search	NOUN
cajgh-29	198	3	of	of	ADP
cajgh-29	198	4	the	the	DET
cajgh-29	198	5	tomour	tomour	NOUN
cajgh-29	198	6	-	-	ADJ
cajgh-29	198	7	supperssor	supperssor	NOUN
cajgh-29	198	8	function	function	NOUN
cajgh-29	198	9	of	of	ADP
cajgh-29	198	10	brca1and	brca1and	PROPN
cajgh-29	198	11	brca2	brca2	PROPN
cajgh-29	198	12	.	.	PUNCT
cajgh-29	198	13	nature	nature	NOUN
cajgh-29	198	14	.	.	PUNCT
cajgh-29	199	1	2000	2000	NUM
cajgh-29	199	2	;	;	PUNCT
cajgh-29	199	3	408:429	408:429	NOUN
cajgh-29	199	4	-	-	PUNCT
cajgh-29	199	5	432	432	NUM
cajgh-29	199	6	.	.	PUNCT
cajgh-29	200	1	7	7	X
cajgh-29	200	2	.	.	X
cajgh-29	200	3	scully	scully	PROPN
cajgh-29	200	4	r	r	PROPN
cajgh-29	200	5	,	,	PUNCT
cajgh-29	200	6	puget	puget	PROPN
cajgh-29	200	7	n	n	CCONJ
cajgh-29	200	8	,	,	PUNCT
cajgh-29	200	9	vlasakova	vlasakova	PROPN
cajgh-29	200	10	k.	k.	PROPN
cajgh-29	200	11	dna	dna	PROPN
cajgh-29	200	12	polymerase	polymerase	PROPN
cajgh-29	200	13	stalling	stalling	NOUN
cajgh-29	200	14	,	,	PUNCT
cajgh-29	200	15	sister	sister	NOUN
cajgh-29	200	16	chromatid	chromatid	ADJ
cajgh-29	200	17	recombination	recombination	NOUN
cajgh-29	200	18	and	and	CCONJ
cajgh-29	200	19	the	the	DET
cajgh-29	200	20	brca	brca	PROPN
cajgh-29	200	21	genes	gene	NOUN
cajgh-29	200	22	.	.	PUNCT
cajgh-29	201	1	oncogenes	oncogene	NOUN
cajgh-29	201	2	.	.	PUNCT
cajgh-29	202	1	2000	2000	NUM
cajgh-29	202	2	;	;	PUNCT
cajgh-29	203	1	19:6176	19:6176	X
cajgh-29	203	2	-	-	SYM
cajgh-29	203	3	6183	6183	NUM
cajgh-29	203	4	.	.	PUNCT
cajgh-29	204	1	8	8	NUM
cajgh-29	204	2	.	.	X
cajgh-29	205	1	wang	wang	PROPN
cajgh-29	205	2	q	q	PROPN
cajgh-29	205	3	,	,	PUNCT
cajgh-29	205	4	zhang	zhang	PROPN
cajgh-29	205	5	h	h	PROPN
cajgh-29	205	6	,	,	PUNCT
cajgh-29	205	7	fishel	fishel	PROPN
cajgh-29	205	8	r	r	PROPN
cajgh-29	205	9	,	,	PUNCT
cajgh-29	205	10	greene	greene	PROPN
cajgh-29	205	11	mi	mi	PROPN
cajgh-29	205	12	.	.	PROPN
cajgh-29	205	13	brca1	brca1	PROPN
cajgh-29	205	14	and	and	CCONJ
cajgh-29	205	15	cell	cell	NOUN
cajgh-29	205	16	signaling	signal	VERB
cajgh-29	205	17	.	.	PUNCT
cajgh-29	206	1	oncogene	oncogene	NOUN
cajgh-29	206	2	.	.	PUNCT
cajgh-29	207	1	2000	2000	NUM
cajgh-29	207	2	;	;	PUNCT
cajgh-29	207	3	19:6152	19:6152	NUM
cajgh-29	207	4	-	-	SYM
cajgh-29	207	5	6158	6158	NUM
cajgh-29	207	6	.	.	PUNCT
cajgh-29	208	1	9	9	X
cajgh-29	208	2	.	.	X
cajgh-29	208	3	zhang	zhang	PROPN
cajgh-29	208	4	l	l	PROPN
cajgh-29	208	5	,	,	PUNCT
cajgh-29	208	6	li	li	PROPN
cajgh-29	208	7	s	s	PROPN
cajgh-29	208	8	,	,	PUNCT
cajgh-29	208	9	boyer	boyer	PROPN
cajgh-29	208	10	tg	tg	PROPN
cajgh-29	208	11	,	,	PUNCT
cajgh-29	208	12	lee	lee	PROPN
cajgh-29	208	13	wh	wh	PROPN
cajgh-29	208	14	.	.	PUNCT
cajgh-29	209	1	lessons	lesson	NOUN
cajgh-29	209	2	learned	learn	VERB
cajgh-29	209	3	from	from	ADP
cajgh-29	209	4	brca1	brca1	PROPN
cajgh-29	209	5	and	and	CCONJ
cajgh-29	209	6	brca2	brca2	PROPN
cajgh-29	209	7	.	.	PUNCT
cajgh-29	210	1	oncogene	oncogene	NOUN
cajgh-29	210	2	.	.	PUNCT
cajgh-29	211	1	2000	2000	NUM
cajgh-29	211	2	;	;	PUNCT
cajgh-29	211	3	19:6159	19:6159	NUM
cajgh-29	211	4	-	-	SYM
cajgh-29	211	5	6175	6175	NUM
cajgh-29	211	6	.	.	PUNCT
cajgh-29	212	1	10	10	NUM
cajgh-29	212	2	.	.	PUNCT
cajgh-29	213	1	zhong	zhong	PROPN
cajgh-29	213	2	q	q	PROPN
cajgh-29	213	3	,	,	PUNCT
cajgh-29	213	4	chen	chen	PROPN
cajgh-29	213	5	cf	cf	PROPN
cajgh-29	213	6	,	,	PUNCT
cajgh-29	213	7	li	li	PROPN
cajgh-29	213	8	s	s	PROPN
cajgh-29	213	9	,	,	PUNCT
cajgh-29	213	10	chen	chen	PROPN
cajgh-29	213	11	y	y	PROPN
cajgh-29	213	12	,	,	PUNCT
cajgh-29	213	13	wang	wang	PROPN
cajgh-29	213	14	cc	cc	PROPN
cajgh-29	213	15	,	,	PUNCT
cajgh-29	213	16	xiao	xiao	PROPN
cajgh-29	213	17	j	j	PROPN
cajgh-29	213	18	,	,	PUNCT
cajgh-29	213	19	chen	chen	PROPN
cajgh-29	213	20	pl	pl	PROPN
cajgh-29	213	21	,	,	PUNCT
cajgh-29	213	22	sharp	sharp	PROPN
cajgh-29	213	23	zd	zd	PROPN
cajgh-29	213	24	,	,	PUNCT
cajgh-29	213	25	lee	lee	PROPN
cajgh-29	213	26	wh	wh	PROPN
cajgh-29	213	27	.	.	PUNCT
cajgh-29	213	28	association	association	PROPN
cajgh-29	213	29	of	of	ADP
cajgh-29	213	30	brca1	brca1	PROPN
cajgh-29	213	31	with	with	ADP
cajgh-29	213	32	the	the	DET
cajgh-29	213	33	hrad50	hrad50	ADJ
cajgh-29	213	34	-	-	PUNCT
cajgh-29	213	35	hmre11	hmre11	ADJ
cajgh-29	213	36	-	-	PUNCT
cajgh-29	213	37	p95	p95	NOUN
cajgh-29	213	38	complex	complex	NOUN
cajgh-29	213	39	and	and	CCONJ
cajgh-29	213	40	the	the	DET
cajgh-29	213	41	dna	dna	PROPN
cajgh-29	213	42	damage	damage	NOUN
cajgh-29	213	43	response	response	NOUN
cajgh-29	213	44	.	.	PUNCT
cajgh-29	214	1	science	science	NOUN
cajgh-29	214	2	.	.	PUNCT
cajgh-29	215	1	1999	1999	NUM
cajgh-29	215	2	;	;	PUNCT
cajgh-29	215	3	285:747	285:747	PROPN
cajgh-29	215	4	-	-	SYM
cajgh-29	215	5	750	750	NUM
cajgh-29	215	6	.	.	PUNCT
cajgh-29	216	1	11	11	NUM
cajgh-29	216	2	.	.	PUNCT
cajgh-29	217	1	welcsh	welcsh	PROPN
cajgh-29	217	2	piri	piri	PROPN
cajgh-29	217	3	l	l	NOUN
cajgh-29	217	4	,	,	PUNCT
cajgh-29	217	5	king	king	PROPN
cajgh-29	217	6	mary	mary	PROPN
cajgh-29	217	7	-	-	PUNCT
cajgh-29	217	8	claire	claire	PROPN
cajgh-29	217	9	:	:	PUNCT
cajgh-29	217	10	brca1	brca1	PROPN
cajgh-29	217	11	and	and	CCONJ
cajgh-29	217	12	brca2	brca2	PROPN
cajgh-29	217	13	and	and	CCONJ
cajgh-29	217	14	genetics	genetic	NOUN
cajgh-29	217	15	of	of	ADP
cajgh-29	217	16	breast	breast	NOUN
cajgh-29	217	17	and	and	CCONJ
cajgh-29	217	18	ovarian	ovarian	ADJ
cajgh-29	217	19	cancer	cancer	NOUN
cajgh-29	217	20	.	.	PUNCT
cajgh-29	218	1	human	human	ADJ
cajgh-29	218	2	molecular	molecular	ADJ
cajgh-29	218	3	genetics	genetic	NOUN
cajgh-29	218	4	.	.	PUNCT
cajgh-29	219	1	2001	2001	NUM
cajgh-29	219	2	;	;	PUNCT
cajgh-29	219	3	10:7705	10:7705	NUM
cajgh-29	219	4	-	-	SYM
cajgh-29	219	5	713	713	NUM
cajgh-29	219	6	.	.	PUNCT
cajgh-29	220	1	12	12	NUM
cajgh-29	220	2	.	.	PUNCT
cajgh-29	221	1	deng	deng	PROPN
cajgh-29	221	2	cx	cx	PROPN
cajgh-29	221	3	,	,	PUNCT
cajgh-29	221	4	brodie	brodie	PROPN
cajgh-29	221	5	sg	sg	PROPN
cajgh-29	221	6	.	.	PUNCT
cajgh-29	221	7	roles	role	NOUN
cajgh-29	221	8	of	of	ADP
cajgh-29	221	9	brca1	brca1	PROPN
cajgh-29	221	10	and	and	CCONJ
cajgh-29	221	11	its	its	PRON
cajgh-29	221	12	interacting	interact	VERB
cajgh-29	221	13	proteins	protein	NOUN
cajgh-29	221	14	.	.	PUNCT
cajgh-29	222	1	bioessays	bioessay	NOUN
cajgh-29	222	2	.	.	PUNCT
cajgh-29	223	1	2000	2000	NUM
cajgh-29	223	2	;	;	PUNCT
cajgh-29	224	1	22:728–737	22:728–737	NUM
cajgh-29	224	2	.	.	NOUN
cajgh-29	224	3	13	13	NUM
cajgh-29	224	4	.	.	PUNCT
cajgh-29	225	1	seery	seery	PROPN
cajgh-29	225	2	lt	lt	PROPN
cajgh-29	225	3	,	,	PUNCT
cajgh-29	225	4	knowlden	knowlden	PROPN
cajgh-29	225	5	jm	jm	PROPN
cajgh-29	225	6	,	,	PUNCT
cajgh-29	225	7	gee	gee	PROPN
cajgh-29	225	8	jm	jm	PROPN
cajgh-29	225	9	,	,	PUNCT
cajgh-29	225	10	et	et	PROPN
cajgh-29	225	11	al	al	PROPN
cajgh-29	225	12	.	.	PUNCT
cajgh-29	226	1	brca1	brca1	PROPN
cajgh-29	226	2	expression	expression	NOUN
cajgh-29	226	3	levels	level	NOUN
cajgh-29	226	4	predict	predict	VERB
cajgh-29	226	5	distant	distant	ADJ
cajgh-29	226	6	metastasis	metastasis	NOUN
cajgh-29	226	7	of	of	ADP
cajgh-29	226	8	sporadic	sporadic	ADJ
cajgh-29	226	9	breast	breast	NOUN
cajgh-29	226	10	cancers	cancer	NOUN
cajgh-29	226	11	.	.	PUNCT
cajgh-29	227	1	int	int	NOUN
cajgh-29	227	2	j	j	PROPN
cajgh-29	227	3	cancer	cancer	NOUN
cajgh-29	227	4	.	.	PUNCT
cajgh-29	228	1	1999	1999	NUM
cajgh-29	228	2	;	;	PUNCT
cajgh-29	229	1	84:258–262	84:258–262	NUM
cajgh-29	229	2	.	.	PUNCT
cajgh-29	229	3	14	14	NUM
cajgh-29	229	4	.	.	PUNCT
cajgh-29	230	1	wilson	wilson	PROPN
cajgh-29	230	2	ca	ca	PROPN
cajgh-29	230	3	,	,	PUNCT
cajgh-29	230	4	ramos	ramos	PROPN
cajgh-29	230	5	l	l	PROPN
cajgh-29	230	6	,	,	PUNCT
cajgh-29	230	7	villaseñor	villaseñor	PROPN
cajgh-29	230	8	mr	mr	PROPN
cajgh-29	230	9	,	,	PUNCT
cajgh-29	230	10	et	et	PROPN
cajgh-29	230	11	al	al	PROPN
cajgh-29	230	12	.	.	PUNCT
cajgh-29	230	13	localization	localization	NOUN
cajgh-29	230	14	of	of	ADP
cajgh-29	230	15	human	human	PROPN
cajgh-29	230	16	brca1	brca1	PROPN
cajgh-29	230	17	and	and	CCONJ
cajgh-29	230	18	its	its	PRON
cajgh-29	230	19	loss	loss	NOUN
cajgh-29	230	20	in	in	ADP
cajgh-29	230	21	high	high	ADJ
cajgh-29	230	22	-	-	PUNCT
cajgh-29	230	23	grade	grade	NOUN
cajgh-29	230	24	,	,	PUNCT
cajgh-29	230	25	non	non	ADJ
cajgh-29	230	26	-	-	ADJ
cajgh-29	230	27	inherited	inherit	VERB
cajgh-29	230	28	breast	breast	NOUN
cajgh-29	230	29	carcinoma	carcinoma	NOUN
cajgh-29	230	30	.	.	PUNCT
cajgh-29	231	1	nat	nat	PROPN
cajgh-29	231	2	genet	genet	PROPN
cajgh-29	231	3	.	.	PUNCT
cajgh-29	232	1	1999	1999	NUM
cajgh-29	232	2	;	;	PUNCT
cajgh-29	233	1	21:236–240	21:236–240	NUM
cajgh-29	233	2	.	.	PUNCT
cajgh-29	233	3	15	15	NUM
cajgh-29	233	4	.	.	PUNCT
cajgh-29	234	1	yoshikawa	yoshikawa	PROPN
cajgh-29	234	2	k	k	PROPN
cajgh-29	234	3	,	,	PUNCT
cajgh-29	234	4	honda	honda	PROPN
cajgh-29	234	5	k	k	PROPN
cajgh-29	234	6	,	,	PUNCT
cajgh-29	234	7	inamoto	inamoto	PROPN
cajgh-29	234	8	t	t	PROPN
cajgh-29	234	9	,	,	PUNCT
cajgh-29	234	10	et	et	PROPN
cajgh-29	234	11	al	al	PROPN
cajgh-29	234	12	.	.	PROPN
cajgh-29	234	13	reduction	reduction	NOUN
cajgh-29	234	14	of	of	ADP
cajgh-29	234	15	brca1	brca1	NOUN
cajgh-29	234	16	protein	protein	NOUN
cajgh-29	234	17	expression	expression	NOUN
cajgh-29	234	18	in	in	ADP
cajgh-29	234	19	japanese	japanese	ADJ
cajgh-29	234	20	sporadic	sporadic	ADJ
cajgh-29	234	21	breast	breast	NOUN
cajgh-29	234	22	carcinomas	carcinoma	NOUN
cajgh-29	234	23	and	and	CCONJ
cajgh-29	234	24	its	its	PRON
cajgh-29	234	25	frequent	frequent	ADJ
cajgh-29	234	26	loss	loss	NOUN
cajgh-29	234	27	in	in	ADP
cajgh-29	234	28	brca1	brca1	PROPN
cajgh-29	234	29	-	-	ADJ
cajgh-29	234	30	associated	associate	VERB
cajgh-29	234	31	cases	case	NOUN
cajgh-29	234	32	.	.	PUNCT
cajgh-29	235	1	clin	clin	PROPN
cajgh-29	235	2	cancer	cancer	NOUN
cajgh-29	235	3	res	re	NOUN
cajgh-29	235	4	.	.	PUNCT
cajgh-29	235	5	1999	1999	NUM
cajgh-29	235	6	;	;	PUNCT
cajgh-29	235	7	5:1249–1261	5:1249–1261	NUM
cajgh-29	235	8	.	.	NOUN
cajgh-29	235	9	16	16	NUM
cajgh-29	235	10	.	.	PUNCT
cajgh-29	235	11	albertsen	albertsen	PROPN
cajgh-29	235	12	hm	hm	PROPN
cajgh-29	235	13	,	,	PUNCT
cajgh-29	235	14	smith	smith	PROPN
cajgh-29	235	15	sa	sa	PROPN
cajgh-29	235	16	,	,	PUNCT
cajgh-29	235	17	mazoyer	mazoyer	NOUN
cajgh-29	235	18	s	s	PROPN
cajgh-29	235	19	,	,	PUNCT
cajgh-29	235	20	et	et	PROPN
cajgh-29	235	21	al	al	PROPN
cajgh-29	235	22	.	.	PUNCT
cajgh-29	236	1	a	a	DET
cajgh-29	236	2	physical	physical	ADJ
cajgh-29	236	3	map	map	NOUN
cajgh-29	236	4	and	and	CCONJ
cajgh-29	236	5	candidate	candidate	NOUN
cajgh-29	236	6	genes	gene	NOUN
cajgh-29	236	7	in	in	ADP
cajgh-29	236	8	the	the	DET
cajgh-29	236	9	brca1	brca1	PROPN
cajgh-29	236	10	region	region	NOUN
cajgh-29	236	11	on	on	ADP
cajgh-29	236	12	chromosome	chromosome	NOUN
cajgh-29	236	13	17q12	17q12	NUM
cajgh-29	236	14	-	-	SYM
cajgh-29	236	15	21	21	NUM
cajgh-29	236	16	.	.	PUNCT
cajgh-29	237	1	nature	nature	PROPN
cajgh-29	237	2	genet	genet	PROPN
cajgh-29	237	3	.	.	PUNCT
cajgh-29	238	1	1994	1994	NUM
cajgh-29	238	2	;	;	PUNCT
cajgh-29	238	3	7:472	7:472	NUM
cajgh-29	238	4	-	-	SYM
cajgh-29	238	5	479	479	NUM
cajgh-29	238	6	.	.	PUNCT
cajgh-29	239	1	17	17	NUM
cajgh-29	239	2	.	.	PUNCT
cajgh-29	240	1	o'connell	o'connell	PROPN
cajgh-29	240	2	p	p	PROPN
cajgh-29	240	3	,	,	PUNCT
cajgh-29	240	4	albertsen	albertsen	ADJ
cajgh-29	240	5	h	h	NOUN
cajgh-29	240	6	,	,	PUNCT
cajgh-29	240	7	matsunami	matsunami	NOUN
cajgh-29	240	8	n	n	CCONJ
cajgh-29	240	9	,	,	PUNCT
cajgh-29	240	10	et	et	PROPN
cajgh-29	240	11	al	al	PROPN
cajgh-29	240	12	.	.	PUNCT
cajgh-29	241	1	a	a	DET
cajgh-29	241	2	radiation	radiation	NOUN
cajgh-29	241	3	hybrid	hybrid	NOUN
cajgh-29	241	4	map	map	NOUN
cajgh-29	241	5	of	of	ADP
cajgh-29	241	6	the	the	DET
cajgh-29	241	7	brca1	brca1	PROPN
cajgh-29	241	8	region	region	NOUN
cajgh-29	241	9	.	.	PUNCT
cajgh-29	242	1	am	be	AUX
cajgh-29	242	2	j	j	PROPN
cajgh-29	242	3	hum	hum	PROPN
cajgh-29	242	4	genet	genet	PROPN
cajgh-29	242	5	.	.	PUNCT
cajgh-29	243	1	1994	1994	NUM
cajgh-29	243	2	;	;	PUNCT
cajgh-29	243	3	54:526	54:526	NUM
cajgh-29	243	4	-	-	SYM
cajgh-29	243	5	534	534	NUM
cajgh-29	243	6	.	.	NUM
cajgh-29	244	1	18	18	NUM
cajgh-29	244	2	.	.	PUNCT
cajgh-29	245	1	matsushima	matsushima	PROPN
cajgh-29	245	2	m	m	PROPN
cajgh-29	245	3	,	,	PUNCT
cajgh-29	245	4	kobayashi	kobayashi	PROPN
cajgh-29	245	5	k	k	PROPN
cajgh-29	245	6	,	,	PUNCT
cajgh-29	245	7	emi	emi	PROPN
cajgh-29	245	8	m	m	PROPN
cajgh-29	245	9	,	,	PUNCT
cajgh-29	245	10	saito	saito	PROPN
cajgh-29	245	11	h	h	PROPN
cajgh-29	245	12	,	,	PUNCT
cajgh-29	245	13	saito	saito	PROPN
cajgh-29	245	14	j	j	PROPN
cajgh-29	245	15	,	,	PUNCT
cajgh-29	245	16	suzumori	suzumori	PROPN
cajgh-29	245	17	k	k	PROPN
cajgh-29	245	18	,	,	PUNCT
cajgh-29	245	19	nakamura	nakamura	PROPN
cajgh-29	245	20	y.	y.	PROPN
cajgh-29	245	21	mutation	mutation	PROPN
cajgh-29	245	22	analysis	analysis	NOUN
cajgh-29	245	23	of	of	ADP
cajgh-29	245	24	the	the	DET
cajgh-29	245	25	brca1	brca1	PROPN
cajgh-29	245	26	gene	gene	NOUN
cajgh-29	245	27	in	in	ADP
cajgh-29	245	28	76	76	NUM
cajgh-29	245	29	japanese	japanese	ADJ
cajgh-29	245	30	ovarian	ovarian	ADJ
cajgh-29	245	31	cancer	cancer	NOUN
cajgh-29	245	32	patients	patient	NOUN
cajgh-29	245	33	:	:	PUNCT
cajgh-29	245	34	four	four	NUM
cajgh-29	245	35	germline	germline	NOUN
cajgh-29	245	36	mutations	mutation	NOUN
cajgh-29	245	37	,	,	PUNCT
cajgh-29	245	38	but	but	CCONJ
cajgh-29	245	39	no	no	DET
cajgh-29	245	40	evidence	evidence	NOUN
cajgh-29	245	41	of	of	ADP
cajgh-29	245	42	somatic	somatic	ADJ
cajgh-29	245	43	mutation	mutation	NOUN
cajgh-29	245	44	.	.	PUNCT
cajgh-29	246	1	hum	hum	PROPN
cajgh-29	246	2	mol	mol	ADP
cajgh-29	246	3	genet	genet	PROPN
cajgh-29	246	4	.	.	PUNCT
cajgh-29	247	1	1996	1996	NUM
cajgh-29	247	2	;	;	PUNCT
cajgh-29	247	3	4:1953	4:1953	NUM
cajgh-29	247	4	-	-	SYM
cajgh-29	247	5	1956	1956	NUM
cajgh-29	247	6	.	.	PUNCT
cajgh-29	248	1	19	19	NUM
cajgh-29	248	2	.	.	X
cajgh-29	248	3	de	de	PROPN
cajgh-29	248	4	benedetti	benedetti	PROPN
cajgh-29	248	5	vm	vm	PROPN
cajgh-29	248	6	,	,	PUNCT
cajgh-29	248	7	radice	radice	PROPN
cajgh-29	248	8	p	p	PROPN
cajgh-29	248	9	,	,	PUNCT
cajgh-29	248	10	mondini	mondini	ADJ
cajgh-29	248	11	p	p	NOUN
cajgh-29	248	12	,	,	PUNCT
cajgh-29	248	13	et	et	PROPN
cajgh-29	248	14	al	al	PROPN
cajgh-29	248	15	.	.	PUNCT
cajgh-29	249	1	screening	screen	VERB
cajgh-29	249	2	for	for	ADP
cajgh-29	249	3	mutations	mutation	NOUN
cajgh-29	249	4	in	in	ADP
cajgh-29	249	5	exon	exon	NOUN
cajgh-29	249	6	11	11	NUM
cajgh-29	249	7	of	of	ADP
cajgh-29	249	8	the	the	DET
cajgh-29	249	9	brca1	brca1	PROPN
cajgh-29	249	10	gene	gene	NOUN
cajgh-29	249	11	in	in	ADP
cajgh-29	249	12	70	70	NUM
cajgh-29	249	13	italian	italian	ADJ
cajgh-29	249	14	breast	breast	NOUN
cajgh-29	249	15	and	and	CCONJ
cajgh-29	249	16	ovarian	ovarian	ADJ
cajgh-29	249	17	cancer	cancer	NOUN
cajgh-29	249	18	patients	patient	NOUN
cajgh-29	249	19	by	by	ADP
cajgh-29	249	20	protein	protein	NOUN
cajgh-29	249	21	truncation	truncation	NOUN
cajgh-29	249	22	test	test	NOUN
cajgh-29	249	23	.	.	PUNCT
cajgh-29	250	1	oncogene	oncogene	NOUN
cajgh-29	250	2	.	.	PUNCT
cajgh-29	251	1	1996	1996	NUM
cajgh-29	251	2	;	;	PUNCT
cajgh-29	252	1	13(6):1353	13(6):1353	NUM
cajgh-29	252	2	-	-	SYM
cajgh-29	252	3	1357	1357	NUM
cajgh-29	252	4	.	.	PUNCT
cajgh-29	253	1	20	20	NUM
cajgh-29	253	2	.	.	PUNCT
cajgh-29	253	3	katagiri	katagiri	PROPN
cajgh-29	253	4	t	t	PROPN
cajgh-29	253	5	,	,	PUNCT
cajgh-29	253	6	emi	emi	PROPN
cajgh-29	253	7	m	m	PROPN
cajgh-29	253	8	,	,	PUNCT
cajgh-29	253	9	ito	ito	PROPN
cajgh-29	253	10	i	i	PROPN
cajgh-29	253	11	,	,	PUNCT
cajgh-29	253	12	et	et	PROPN
cajgh-29	253	13	al	al	PROPN
cajgh-29	253	14	.	.	PUNCT
cajgh-29	254	1	mutations	mutation	NOUN
cajgh-29	254	2	in	in	ADP
cajgh-29	254	3	the	the	DET
cajgh-29	254	4	brca1	brca1	PROPN
cajgh-29	254	5	gene	gene	NOUN
cajgh-29	254	6	in	in	ADP
cajgh-29	254	7	japanese	japanese	ADJ
cajgh-29	254	8	breast	breast	NOUN
cajgh-29	254	9	cancer	cancer	NOUN
cajgh-29	254	10	patients	patient	NOUN
cajgh-29	254	11	.	.	PUNCT
cajgh-29	255	1	hum	hum	PROPN
cajgh-29	255	2	mutat	mutat	PROPN
cajgh-29	255	3	.	.	PUNCT
cajgh-29	255	4	1996	1996	NUM
cajgh-29	255	5	;	;	PUNCT
cajgh-29	256	1	7:334	7:334	X
cajgh-29	256	2	-	-	SYM
cajgh-29	256	3	339	339	NUM
cajgh-29	256	4	.	.	PUNCT
cajgh-29	256	5	21	21	NUM
cajgh-29	256	6	.	.	PUNCT
cajgh-29	257	1	håkansson	håkansson	PROPN
cajgh-29	257	2	s	s	PROPN
cajgh-29	257	3	,	,	PUNCT
cajgh-29	257	4	johannsson	johannsson	PROPN
cajgh-29	257	5	o	o	PROPN
cajgh-29	257	6	,	,	PUNCT
cajgh-29	257	7	johansson	johansson	PROPN
cajgh-29	257	8	u	u	PROPN
cajgh-29	257	9	,	,	PUNCT
cajgh-29	257	10	et	et	PROPN
cajgh-29	257	11	al	al	PROPN
cajgh-29	257	12	.	.	PROPN
cajgh-29	257	13	moderate	moderate	ADJ
cajgh-29	257	14	frequency	frequency	NOUN
cajgh-29	257	15	of	of	ADP
cajgh-29	257	16	brca1	brca1	PROPN
cajgh-29	257	17	and	and	CCONJ
cajgh-29	257	18	brca2	brca2	PROPN
cajgh-29	257	19	germ	germ	NOUN
cajgh-29	257	20	-	-	PUNCT
cajgh-29	257	21	line	line	NOUN
cajgh-29	257	22	mutations	mutation	NOUN
cajgh-29	257	23	in	in	ADP
cajgh-29	257	24	scandinavian	scandinavian	ADJ
cajgh-29	257	25	familial	familial	ADJ
cajgh-29	257	26	breast	breast	NOUN
cajgh-29	257	27	cancer	cancer	NOUN
cajgh-29	257	28	.	.	PUNCT
cajgh-29	257	29	am	be	AUX
cajgh-29	257	30	j	j	PROPN
cajgh-29	257	31	hum	hum	PROPN
cajgh-29	257	32	genet	genet	PROPN
cajgh-29	257	33	.	.	PUNCT
cajgh-29	258	1	1997	1997	NUM
cajgh-29	258	2	;	;	PUNCT
cajgh-29	258	3	60:1068–1078	60:1068–1078	NUM
cajgh-29	258	4	.	.	PUNCT
cajgh-29	259	1	22	22	NUM
cajgh-29	259	2	.	.	PUNCT
cajgh-29	260	1	vehmanen	vehmanen	PROPN
cajgh-29	260	2	p	p	PROPN
cajgh-29	260	3	,	,	PUNCT
cajgh-29	260	4	friedman	friedman	PROPN
cajgh-29	260	5	ls	ls	PROPN
cajgh-29	260	6	,	,	PUNCT
cajgh-29	260	7	eerola	eerola	PROPN
cajgh-29	260	8	h	h	PROPN
cajgh-29	260	9	,	,	PUNCT
cajgh-29	260	10	mcclure	mcclure	PROPN
cajgh-29	260	11	m	m	PROPN
cajgh-29	260	12	,	,	PUNCT
cajgh-29	260	13	ward	ward	PROPN
cajgh-29	260	14	b	b	NUM
cajgh-29	260	15	,	,	PUNCT
cajgh-29	260	16	sarantaus	sarantaus	PROPN
cajgh-29	260	17	l.	l.	PROPN
cajgh-29	260	18	low	low	PROPN
cajgh-29	260	19	proportion	proportion	NOUN
cajgh-29	260	20	of	of	ADP
cajgh-29	260	21	brca1	brca1	PROPN
cajgh-29	260	22	and	and	CCONJ
cajgh-29	260	23	brca2	brca2	NOUN
cajgh-29	260	24	mutations	mutation	NOUN
cajgh-29	260	25	in	in	ADP
cajgh-29	260	26	finnish	finnish	ADJ
cajgh-29	260	27	breast	breast	NOUN
cajgh-29	260	28	cancer	cancer	NOUN
cajgh-29	260	29	families	family	NOUN
cajgh-29	260	30	:	:	PUNCT
cajgh-29	260	31	evidence	evidence	NOUN
cajgh-29	260	32	for	for	ADP
cajgh-29	260	33	additional	additional	ADJ
cajgh-29	260	34	susceptibility	susceptibility	NOUN
cajgh-29	260	35	genes	gene	NOUN
cajgh-29	260	36	.	.	PUNCT
cajgh-29	261	1	hum	hum	PROPN
cajgh-29	261	2	mol	mol	ADP
cajgh-29	261	3	genet	genet	NOUN
cajgh-29	261	4	.	.	PUNCT
cajgh-29	262	1	1997	1997	NUM
cajgh-29	262	2	;	;	PUNCT
cajgh-29	262	3	6:2309–2315	6:2309–2315	NUM
cajgh-29	262	4	.	.	PUNCT
cajgh-29	263	1	23	23	NUM
cajgh-29	263	2	.	.	PUNCT
cajgh-29	264	1	miki	miki	PROPN
cajgh-29	264	2	y	y	PROPN
cajgh-29	264	3	,	,	PUNCT
cajgh-29	264	4	swensen	swensen	PROPN
cajgh-29	264	5	j	j	PROPN
cajgh-29	264	6	,	,	PUNCT
cajgh-29	264	7	shattuck	shattuck	PROPN
cajgh-29	264	8	-	-	PUNCT
cajgh-29	264	9	eidens	eiden	VERB
cajgh-29	264	10	d	d	NOUN
cajgh-29	264	11	,	,	PUNCT
cajgh-29	264	12	futreal	futreal	ADJ
cajgh-29	264	13	pa	pa	PROPN
cajgh-29	264	14	,	,	PUNCT
cajgh-29	264	15	harshman	harshman	PROPN
cajgh-29	264	16	k	k	PROPN
cajgh-29	264	17	,	,	PUNCT
cajgh-29	264	18	tavtigian	tavtigian	PROPN
cajgh-29	264	19	s	s	PROPN
cajgh-29	264	20	,	,	PUNCT
cajgh-29	264	21	liu	liu	PROPN
cajgh-29	264	22	q	q	PROPN
cajgh-29	264	23	,	,	PUNCT
cajgh-29	264	24	cochran	cochran	NOUN
cajgh-29	264	25	c	c	PROPN
cajgh-29	264	26	,	,	PUNCT
cajgh-29	264	27	bennett	bennett	PROPN
cajgh-29	264	28	lm	lm	PROPN
cajgh-29	264	29	,	,	PUNCT
cajgh-29	264	30	ding	de	VERB
cajgh-29	264	31	w.	w.	PROPN
cajgh-29	264	32	a	a	DET
cajgh-29	264	33	strong	strong	ADJ
cajgh-29	264	34	candidate	candidate	NOUN
cajgh-29	264	35	for	for	ADP
cajgh-29	264	36	the	the	DET
cajgh-29	264	37	breast	breast	NOUN
cajgh-29	264	38	and	and	CCONJ
cajgh-29	264	39	ovarian	ovarian	ADJ
cajgh-29	264	40	cancer	cancer	NOUN
cajgh-29	264	41	susceptibility	susceptibility	NOUN
cajgh-29	264	42	gene	gene	PROPN
cajgh-29	264	43	brca1	brca1	PROPN
cajgh-29	264	44	.	.	PUNCT
cajgh-29	265	1	science	science	PROPN
cajgh-29	265	2	.	.	PUNCT
cajgh-29	265	3	1994	1994	NUM
cajgh-29	265	4	;	;	PUNCT
cajgh-29	265	5	266:66	266:66	NUM
cajgh-29	265	6	-	-	SYM
cajgh-29	265	7	71	71	NUM
cajgh-29	265	8	.	.	PUNCT
cajgh-29	265	9	24	24	NUM
cajgh-29	265	10	.	.	PUNCT
cajgh-29	266	1	wooster	wooster	PROPN
cajgh-29	266	2	r	r	PROPN
cajgh-29	266	3	,	,	PUNCT
cajgh-29	266	4	bignell	bignell	VERB
cajgh-29	266	5	g	g	NOUN
cajgh-29	266	6	,	,	PUNCT
cajgh-29	266	7	lancaster	lancaster	PROPN
cajgh-29	266	8	j	j	PROPN
cajgh-29	266	9	,	,	PUNCT
cajgh-29	266	10	swift	swift	ADJ
cajgh-29	266	11	s	s	NOUN
cajgh-29	266	12	,	,	PUNCT
cajgh-29	266	13	seal	seal	NOUN
cajgh-29	266	14	s	s	PART
cajgh-29	266	15	,	,	PUNCT
cajgh-29	266	16	mangion	mangion	PROPN
cajgh-29	266	17	j	j	PROPN
cajgh-29	266	18	,	,	PUNCT
cajgh-29	266	19	collins	collins	PROPN
cajgh-29	266	20	n	n	PRON
cajgh-29	266	21	,	,	PUNCT
cajgh-29	266	22	gregory	gregory	PROPN
cajgh-29	266	23	s	s	PROPN
cajgh-29	266	24	,	,	PUNCT
cajgh-29	266	25	gumbs	gumbs	ADJ
cajgh-29	266	26	c	c	NOUN
cajgh-29	266	27	,	,	PUNCT
cajgh-29	266	28	micklem	micklem	NOUN
cajgh-29	266	29	g.	g.	NOUN
cajgh-29	266	30	identification	identification	NOUN
cajgh-29	266	31	of	of	ADP
cajgh-29	266	32	the	the	DET
cajgh-29	266	33	breast	breast	NOUN
cajgh-29	266	34	cancer	cancer	NOUN
cajgh-29	266	35	susceptibility	susceptibility	NOUN
cajgh-29	266	36	gene	gene	NOUN
cajgh-29	266	37	brca2	brca2	PROPN
cajgh-29	266	38	.	.	PUNCT
cajgh-29	267	1	nature	nature	NOUN
cajgh-29	267	2	.	.	PUNCT
cajgh-29	268	1	1995	1995	NUM
cajgh-29	268	2	;	;	PUNCT
cajgh-29	268	3	378:789	378:789	NUM
cajgh-29	268	4	-	-	SYM
cajgh-29	268	5	92	92	NUM
cajgh-29	268	6	.	.	PUNCT
cajgh-29	269	1	25	25	NUM
cajgh-29	269	2	.	.	PUNCT
cajgh-29	270	1	tavtigian	tavtigian	PROPN
cajgh-29	270	2	sv	sv	PROPN
cajgh-29	270	3	,	,	PUNCT
cajgh-29	270	4	simard	simard	PROPN
cajgh-29	270	5	j	j	PROPN
cajgh-29	270	6	,	,	PUNCT
cajgh-29	270	7	rommens	rommens	PROPN
cajgh-29	270	8	j	j	PROPN
cajgh-29	270	9	,	,	PUNCT
cajgh-29	270	10	couch	couch	NOUN
cajgh-29	270	11	f	f	NOUN
cajgh-29	270	12	,	,	PUNCT
cajgh-29	270	13	shattuck	shattuck	NOUN
cajgh-29	270	14	-	-	PUNCT
cajgh-29	270	15	eidens	eiden	VERB
cajgh-29	270	16	d	d	NOUN
cajgh-29	270	17	,	,	PUNCT
cajgh-29	270	18	neuhausen	neuhausen	PROPN
cajgh-29	270	19	s	s	PART
cajgh-29	270	20	,	,	PUNCT
cajgh-29	270	21	et	et	PROPN
cajgh-29	270	22	al	al	PROPN
cajgh-29	270	23	.	.	PUNCT
cajgh-29	271	1	the	the	DET
cajgh-29	271	2	complete	complete	ADJ
cajgh-29	271	3	brca2	brca2	NOUN
cajgh-29	271	4	gene	gene	NOUN
cajgh-29	271	5	and	and	CCONJ
cajgh-29	271	6	mutations	mutation	NOUN
cajgh-29	271	7	in	in	ADP
cajgh-29	271	8	chromosome13q	chromosome13q	NOUN
cajgh-29	271	9	-	-	PUNCT
cajgh-29	271	10	linked	link	VERB
cajgh-29	271	11	kindreds	kindred	NOUN
cajgh-29	271	12	.	.	PUNCT
cajgh-29	272	1	nat	nat	PROPN
cajgh-29	272	2	genet	genet	PROPN
cajgh-29	272	3	.	.	PUNCT
cajgh-29	273	1	1996	1996	NUM
cajgh-29	273	2	,	,	PUNCT
cajgh-29	273	3	12:333	12:333	NUM
cajgh-29	273	4	-	-	SYM
cajgh-29	273	5	337	337	NUM
cajgh-29	273	6	.	.	PUNCT
cajgh-29	274	1	26	26	NUM
cajgh-29	274	2	.	.	PUNCT
cajgh-29	274	3	breast	breast	NOUN
cajgh-29	274	4	cancer	cancer	NOUN
cajgh-29	274	5	information	information	NOUN
cajgh-29	274	6	core	core	NOUN
cajgh-29	274	7	database	database	NOUN
cajgh-29	274	8	(	(	PUNCT
cajgh-29	274	9	bic	bic	PROPN
cajgh-29	274	10	)	)	PUNCT
cajgh-29	274	11	.	.	PUNCT
cajgh-29	275	1	available	available	ADJ
cajgh-29	275	2	from	from	ADP
cajgh-29	275	3	:	:	PUNCT
cajgh-29	275	4	http://research.nhgri.nih.gov/bic	http://research.nhgri.nih.gov/bic	ADJ
cajgh-29	275	5	.	.	PUNCT
cajgh-29	276	1	27	27	NUM
cajgh-29	276	2	.	.	PUNCT
cajgh-29	277	1	narod	narod	PROPN
cajgh-29	277	2	sa	sa	PROPN
cajgh-29	277	3	,	,	PUNCT
cajgh-29	277	4	goldgar	goldgar	ADJ
cajgh-29	277	5	d	d	NOUN
cajgh-29	277	6	,	,	PUNCT
cajgh-29	277	7	cannon	cannon	NOUN
cajgh-29	277	8	-	-	PUNCT
cajgh-29	277	9	albright	albright	NOUN
cajgh-29	277	10	l	l	PROPN
cajgh-29	277	11	,	,	PUNCT
cajgh-29	277	12	et	et	PROPN
cajgh-29	277	13	al	al	PROPN
cajgh-29	277	14	.	.	PUNCT
cajgh-29	277	15	risk	risk	NOUN
cajgh-29	277	16	modifiers	modifier	NOUN
cajgh-29	277	17	in	in	ADP
cajgh-29	277	18	carriers	carrier	NOUN
cajgh-29	277	19	of	of	ADP
cajgh-29	277	20	brca1	brca1	PROPN
cajgh-29	277	21	mutations	mutation	NOUN
cajgh-29	277	22	.	.	PUNCT
cajgh-29	278	1	int	int	NOUN
cajgh-29	278	2	j	j	PROPN
cajgh-29	278	3	cancer	cancer	NOUN
cajgh-29	278	4	.	.	PUNCT
cajgh-29	279	1	1995	1995	NUM
cajgh-29	279	2	;	;	PUNCT
cajgh-29	279	3	64	64	NUM
cajgh-29	279	4	:	:	PUNCT
cajgh-29	279	5	394–398	394–398	NUM
cajgh-29	279	6	.	.	PUNCT
cajgh-29	280	1	28	28	NUM
cajgh-29	280	2	.	.	PUNCT
cajgh-29	281	1	ford	ford	PROPN
cajgh-29	281	2	d	d	PROPN
cajgh-29	281	3	,	,	PUNCT
cajgh-29	281	4	easton	easton	PROPN
cajgh-29	281	5	df	df	PROPN
cajgh-29	281	6	,	,	PUNCT
cajgh-29	281	7	peto	peto	PROPN
cajgh-29	281	8	j.	j.	PROPN
cajgh-29	281	9	estimates	estimate	NOUN
cajgh-29	281	10	of	of	ADP
cajgh-29	281	11	the	the	DET
cajgh-29	281	12	gene	gene	NOUN
cajgh-29	281	13	frequency	frequency	NOUN
cajgh-29	281	14	of	of	ADP
cajgh-29	281	15	brca1	brca1	PROPN
cajgh-29	281	16	and	and	CCONJ
cajgh-29	281	17	its	its	PRON
cajgh-29	281	18	contribution	contribution	NOUN
cajgh-29	281	19	to	to	ADP
cajgh-29	281	20	breast	breast	NOUN
cajgh-29	281	21	and	and	CCONJ
cajgh-29	281	22	ovarian	ovarian	ADJ
cajgh-29	281	23	cancer	cancer	NOUN
cajgh-29	281	24	incidence	incidence	NOUN
cajgh-29	281	25	.	.	PUNCT
cajgh-29	281	26	am	be	AUX
cajgh-29	281	27	j	j	PROPN
cajgh-29	281	28	hum	hum	PROPN
cajgh-29	281	29	genet	genet	PROPN
cajgh-29	281	30	.	.	PUNCT
cajgh-29	282	1	1995	1995	NUM
cajgh-29	282	2	;	;	PUNCT
cajgh-29	282	3	57:1457–1462	57:1457–1462	NUM
cajgh-29	282	4	.	.	PUNCT
cajgh-29	283	1	29	29	NUM
cajgh-29	283	2	.	.	PUNCT
cajgh-29	283	3	easton	easton	PROPN
cajgh-29	283	4	df	df	PROPN
cajgh-29	283	5	,	,	PUNCT
cajgh-29	283	6	hopper	hopper	NOUN
cajgh-29	283	7	jl	jl	PROPN
cajgh-29	283	8	,	,	PUNCT
cajgh-29	283	9	thomas	thomas	PROPN
cajgh-29	283	10	dc	dc	PROPN
cajgh-29	283	11	,	,	PUNCT
cajgh-29	283	12	antoniou	antoniou	PROPN
cajgh-29	283	13	a	a	NOUN
cajgh-29	283	14	,	,	PUNCT
cajgh-29	283	15	pharoah	pharoah	PROPN
cajgh-29	283	16	pdp	pdp	PROPN
cajgh-29	283	17	,	,	PUNCT
cajgh-29	283	18	whittemore	whittemore	VERB
cajgh-29	283	19	a	a	PRON
cajgh-29	283	20	,	,	PUNCT
cajgh-29	283	21	haile	haile	PROPN
cajgh-29	283	22	rw	rw	PROPN
cajgh-29	283	23	.	.	PUNCT
cajgh-29	284	1	breast	breast	NOUN
cajgh-29	284	2	cancer	cancer	NOUN
cajgh-29	284	3	risks	risk	NOUN
cajgh-29	284	4	for	for	ADP
cajgh-29	284	5	brca1/2	brca1/2	ADJ
cajgh-29	284	6	carriers	carrier	NOUN
cajgh-29	284	7	.	.	PUNCT
cajgh-29	285	1	science	science	NOUN
cajgh-29	285	2	.	.	PUNCT
cajgh-29	286	1	2004	2004	NUM
cajgh-29	286	2	;	;	PUNCT
cajgh-29	286	3	306:2187–2188	306:2187–2188	NUM
cajgh-29	286	4	.	.	NOUN
cajgh-29	286	5	30	30	NUM
cajgh-29	286	6	.	.	PUNCT
cajgh-29	287	1	dunning	dun	VERB
cajgh-29	287	2	am	am	NOUN
cajgh-29	287	3	,	,	PUNCT
cajgh-29	287	4	chiano	chiano	PROPN
cajgh-29	287	5	m	m	PROPN
cajgh-29	287	6	,	,	PUNCT
cajgh-29	287	7	smith	smith	PROPN
cajgh-29	287	8	nr	nr	PROPN
cajgh-29	287	9	,	,	PUNCT
cajgh-29	287	10	et	et	PROPN
cajgh-29	287	11	al	al	PROPN
cajgh-29	287	12	.	.	PROPN
cajgh-29	288	1	common	common	ADJ
cajgh-29	288	2	brca1	brca1	PROPN
cajgh-29	288	3	variants	variant	NOUN
cajgh-29	288	4	and	and	CCONJ
cajgh-29	288	5	susceptibility	susceptibility	NOUN
cajgh-29	288	6	to	to	ADP
cajgh-29	288	7	breast	breast	NOUN
cajgh-29	288	8	and	and	CCONJ
cajgh-29	288	9	ovarian	ovarian	ADJ
cajgh-29	288	10	cancer	cancer	NOUN
cajgh-29	288	11	in	in	ADP
cajgh-29	288	12	the	the	DET
cajgh-29	288	13	general	general	ADJ
cajgh-29	288	14	population	population	NOUN
cajgh-29	288	15	.	.	PUNCT
cajgh-29	289	1	hum	hum	PROPN
cajgh-29	289	2	mol	mol	ADP
cajgh-29	289	3	genet	genet	NOUN
cajgh-29	289	4	.	.	PUNCT
cajgh-29	290	1	1997	1997	NUM
cajgh-29	290	2	;	;	PUNCT
cajgh-29	290	3	6:285–289	6:285–289	NUM
cajgh-29	290	4	.	.	PUNCT
cajgh-29	291	1	31	31	NUM
cajgh-29	291	2	.	.	PUNCT
cajgh-29	292	1	janezic	janezic	PROPN
cajgh-29	292	2	sa	sa	PROPN
cajgh-29	292	3	,	,	PUNCT
cajgh-29	292	4	ziogas	ziogas	PROPN
cajgh-29	292	5	a	a	PRON
cajgh-29	292	6	,	,	PUNCT
cajgh-29	292	7	krumroy	krumroy	NOUN
cajgh-29	292	8	lm	lm	PROPN
cajgh-29	292	9	,	,	PUNCT
cajgh-29	292	10	et	et	PROPN
cajgh-29	292	11	al	al	PROPN
cajgh-29	292	12	.	.	PROPN
cajgh-29	292	13	germline	germline	PROPN
cajgh-29	292	14	brca1	brca1	PROPN
cajgh-29	292	15	alterations	alteration	NOUN
cajgh-29	292	16	in	in	ADP
cajgh-29	292	17	a	a	DET
cajgh-29	292	18	population	population	NOUN
cajgh-29	292	19	based	base	VERB
cajgh-29	292	20	series	series	NOUN
cajgh-29	292	21	of	of	ADP
cajgh-29	292	22	ovarian	ovarian	ADJ
cajgh-29	292	23	cancer	cancer	NOUN
cajgh-29	292	24	cases	case	NOUN
cajgh-29	292	25	.	.	PUNCT
cajgh-29	293	1	hum	hum	PROPN
cajgh-29	293	2	mol	mol	ADP
cajgh-29	293	3	genet	genet	PROPN
cajgh-29	293	4	.	.	PUNCT
cajgh-29	294	1	1999	1999	NUM
cajgh-29	294	2	;	;	PUNCT
cajgh-29	294	3	8:889–897	8:889–897	NUM
cajgh-29	294	4	.	.	PUNCT
cajgh-29	295	1	32	32	NUM
cajgh-29	295	2	.	.	PUNCT
cajgh-29	296	1	healey	healey	PROPN
cajgh-29	296	2	cs	cs	PROPN
cajgh-29	296	3	,	,	PUNCT
cajgh-29	296	4	dunning	dun	VERB
cajgh-29	296	5	am	be	AUX
cajgh-29	296	6	,	,	PUNCT
cajgh-29	296	7	teare	teare	VERB
cajgh-29	296	8	md	md	PROPN
cajgh-29	296	9	,	,	PUNCT
cajgh-29	296	10	et	et	PROPN
cajgh-29	296	11	al	al	PROPN
cajgh-29	296	12	.	.	PUNCT
cajgh-29	297	1	a	a	DET
cajgh-29	297	2	common	common	ADJ
cajgh-29	297	3	variant	variant	NOUN
cajgh-29	297	4	in	in	ADP
cajgh-29	297	5	brca2	brca2	PROPN
cajgh-29	297	6	is	be	AUX
cajgh-29	297	7	associated	associate	VERB
cajgh-29	297	8	with	with	ADP
cajgh-29	297	9	both	both	PRON
cajgh-29	297	10	breast	breast	NOUN
cajgh-29	297	11	cancer	cancer	NOUN
cajgh-29	297	12	risk	risk	NOUN
cajgh-29	297	13	and	and	CCONJ
cajgh-29	297	14	prenatal	prenatal	ADJ
cajgh-29	297	15	viability	viability	NOUN
cajgh-29	297	16	.	.	PUNCT
cajgh-29	298	1	nat	nat	PROPN
cajgh-29	298	2	genet	genet	PROPN
cajgh-29	298	3	.	.	PUNCT
cajgh-29	299	1	2000	2000	NUM
cajgh-29	299	2	;	;	PUNCT
cajgh-29	300	1	26:362–364	26:362–364	NUM
cajgh-29	300	2	.	.	PUNCT
cajgh-29	301	1	33	33	NUM
cajgh-29	301	2	.	.	PUNCT
cajgh-29	302	1	szabo	szabo	PROPN
cajgh-29	302	2	ci	ci	PROPN
cajgh-29	302	3	,	,	PUNCT
cajgh-29	302	4	king	king	PROPN
cajgh-29	302	5	mc	mc	PROPN
cajgh-29	302	6	.	.	PROPN
cajgh-29	303	1	population	population	PROPN
cajgh-29	303	2	genetics	genetic	NOUN
cajgh-29	303	3	of	of	ADP
cajgh-29	303	4	brca1	brca1	PROPN
cajgh-29	303	5	and	and	CCONJ
cajgh-29	303	6	brca2	brca2	PROPN
cajgh-29	303	7	.	.	PUNCT
cajgh-29	304	1	am	be	AUX
cajgh-29	304	2	j	j	PROPN
cajgh-29	304	3	hum	hum	PROPN
cajgh-29	304	4	genet	genet	PROPN
cajgh-29	304	5	.	.	PUNCT
cajgh-29	305	1	1997	1997	NUM
cajgh-29	305	2	;	;	PUNCT
cajgh-29	305	3	60:1013	60:1013	X
cajgh-29	305	4	-	-	SYM
cajgh-29	305	5	1012	1012	NUM
cajgh-29	305	6	.	.	PUNCT
cajgh-29	306	1	34	34	NUM
cajgh-29	306	2	.	.	PUNCT
cajgh-29	306	3	offit	offit	PROPN
cajgh-29	306	4	k	k	PROPN
cajgh-29	306	5	,	,	PUNCT
cajgh-29	306	6	gilewski	gilewski	PROPN
cajgh-29	306	7	t	t	PROPN
cajgh-29	306	8	,	,	PUNCT
cajgh-29	306	9	mcguire	mcguire	PROPN
cajgh-29	306	10	p	p	X
cajgh-29	306	11	,	,	PUNCT
cajgh-29	306	12	et	et	PROPN
cajgh-29	306	13	al	al	PROPN
cajgh-29	306	14	.	.	PROPN
cajgh-29	306	15	germline	germline	PROPN
cajgh-29	306	16	brca1	brca1	PROPN
cajgh-29	306	17	185delag	185delag	PROPN
cajgh-29	306	18	mutations	mutation	NOUN
cajgh-29	306	19	in	in	ADP
cajgh-29	306	20	jewish	jewish	ADJ
cajgh-29	306	21	women	woman	NOUN
cajgh-29	306	22	with	with	ADP
cajgh-29	306	23	breast	breast	NOUN
cajgh-29	306	24	cancer	cancer	NOUN
cajgh-29	306	25	.	.	PUNCT
cajgh-29	307	1	lancet	lancet	PROPN
cajgh-29	307	2	.	.	PUNCT
cajgh-29	308	1	1996	1996	NUM
cajgh-29	308	2	;	;	PUNCT
cajgh-29	309	1	347:1643–1645	347:1643–1645	NUM
cajgh-29	309	2	.	.	PUNCT
cajgh-29	310	1	35	35	NUM
cajgh-29	310	2	.	.	PUNCT
cajgh-29	311	1	abeliovich	abeliovich	PROPN
cajgh-29	312	1	d	d	PROPN
cajgh-29	312	2	,	,	PUNCT
cajgh-29	312	3	kaduri	kaduri	PROPN
cajgh-29	312	4	l	l	PROPN
cajgh-29	312	5	,	,	PUNCT
cajgh-29	312	6	lerer	lerer	PROPN
cajgh-29	312	7	i	i	PRON
cajgh-29	312	8	,	,	PUNCT
cajgh-29	312	9	et	et	PROPN
cajgh-29	312	10	al	al	PROPN
cajgh-29	312	11	.	.	PUNCT
cajgh-29	313	1	the	the	DET
cajgh-29	313	2	founder	founder	NOUN
cajgh-29	313	3	mutations	mutation	VERB
cajgh-29	313	4	185delag	185delag	PROPN
cajgh-29	313	5	and	and	CCONJ
cajgh-29	313	6	5382insc	5382insc	NUM
cajgh-29	313	7	in	in	ADP
cajgh-29	313	8	brca1	brca1	PROPN
cajgh-29	313	9	and	and	CCONJ
cajgh-29	313	10	6174delt	6174delt	NUM
cajgh-29	313	11	in	in	ADP
cajgh-29	313	12	brca2	brca2	PROPN
cajgh-29	313	13	appear	appear	VERB
cajgh-29	313	14	in	in	ADP
cajgh-29	313	15	60	60	NUM
cajgh-29	313	16	%	%	NOUN
cajgh-29	313	17	of	of	ADP
cajgh-29	313	18	ovarian	ovarian	ADJ
cajgh-29	313	19	cancer	cancer	NOUN
cajgh-29	313	20	and	and	CCONJ
cajgh-29	313	21	30	30	NUM
cajgh-29	313	22	%	%	NOUN
cajgh-29	313	23	of	of	ADP
cajgh-29	313	24	early	early	ADJ
cajgh-29	313	25	-	-	PUNCT
cajgh-29	313	26	on	on	ADP
cajgh-29	313	27	-	-	PUNCT
cajgh-29	313	28	set	set	VERB
cajgh-29	313	29	breast	breast	NOUN
cajgh-29	313	30	cancer	cancer	NOUN
cajgh-29	313	31	patients	patient	NOUN
cajgh-29	313	32	among	among	ADP
cajgh-29	313	33	ashkenazi	ashkenazi	ADJ
cajgh-29	313	34	women	woman	NOUN
cajgh-29	313	35	.	.	PUNCT
cajgh-29	314	1	am	be	AUX
cajgh-29	314	2	j	j	PROPN
cajgh-29	314	3	hum	hum	PROPN
cajgh-29	314	4	genet	genet	PROPN
cajgh-29	314	5	.	.	PUNCT
cajgh-29	315	1	1997	1997	NUM
cajgh-29	315	2	;	;	PUNCT
cajgh-29	315	3	60:505	60:505	NUM
cajgh-29	315	4	-	-	SYM
cajgh-29	315	5	514	514	NUM
cajgh-29	315	6	.	.	NUM
cajgh-29	315	7	36	36	NUM
cajgh-29	315	8	.	.	PUNCT
cajgh-29	316	1	johannesdottir	johannesdottir	PROPN
cajgh-29	316	2	g	g	PROPN
cajgh-29	316	3	,	,	PUNCT
cajgh-29	316	4	gudmundsson	gudmundsson	PROPN
cajgh-29	316	5	j	j	PROPN
cajgh-29	316	6	,	,	PUNCT
cajgh-29	316	7	bergthorsson	bergthorsson	PROPN
cajgh-29	316	8	jt	jt	PROPN
cajgh-29	316	9	,	,	PUNCT
cajgh-29	316	10	et	et	PROPN
cajgh-29	316	11	al	al	PROPN
cajgh-29	316	12	.	.	PROPN
cajgh-29	317	1	high	high	ADJ
cajgh-29	317	2	prevalence	prevalence	NOUN
cajgh-29	317	3	of	of	ADP
cajgh-29	317	4	the	the	DET
cajgh-29	317	5	999del5	999del5	NUM
cajgh-29	317	6	mutation	mutation	NOUN
cajgh-29	317	7	in	in	ADP
cajgh-29	317	8	icelandic	icelandic	ADJ
cajgh-29	317	9	breast	breast	NOUN
cajgh-29	317	10	and	and	CCONJ
cajgh-29	317	11	ovarian	ovarian	ADJ
cajgh-29	317	12	cancer	cancer	NOUN
cajgh-29	317	13	patients	patient	NOUN
cajgh-29	317	14	.	.	PUNCT
cajgh-29	318	1	cancer	cancer	NOUN
cajgh-29	318	2	res	re	NOUN
cajgh-29	318	3	.	.	PUNCT
cajgh-29	318	4	1996	1996	NUM
cajgh-29	318	5	;	;	PUNCT
cajgh-29	318	6	56:3663–3665	56:3663–3665	NUM
cajgh-29	318	7	.	.	PUNCT
cajgh-29	319	1	37	37	NUM
cajgh-29	319	2	.	.	PUNCT
cajgh-29	319	3	de	de	PROPN
cajgh-29	319	4	leon	leon	PROPN
cajgh-29	319	5	matsuda	matsuda	PROPN
cajgh-29	319	6	ml	ml	PROPN
cajgh-29	319	7	,	,	PUNCT
cajgh-29	319	8	liede	liede	NOUN
cajgh-29	319	9	a	a	PRON
cajgh-29	319	10	,	,	PUNCT
cajgh-29	319	11	kwan	kwan	PROPN
cajgh-29	319	12	e	e	PROPN
cajgh-29	319	13	,	,	PUNCT
cajgh-29	319	14	mapua	mapua	PROPN
cajgh-29	319	15	ca	ca	PROPN
cajgh-29	319	16	,	,	PUNCT
cajgh-29	319	17	cutiongco	cutiongco	PROPN
cajgh-29	319	18	em	em	PRON
cajgh-29	319	19	,	,	PUNCT
cajgh-29	319	20	tan	tan	PROPN
cajgh-29	319	21	a	a	NOUN
cajgh-29	319	22	,	,	PUNCT
cajgh-29	319	23	borg	borg	PROPN
cajgh-29	319	24	a	a	PROPN
cajgh-29	319	25	,	,	PUNCT
cajgh-29	319	26	narod	narod	PROPN
cajgh-29	319	27	sa	sa	PROPN
cajgh-29	319	28	.	.	PUNCT
cajgh-29	319	29	brca1	brca1	PROPN
cajgh-29	319	30	and	and	CCONJ
cajgh-29	319	31	brca2	brca2	NOUN
cajgh-29	319	32	mutations	mutation	NOUN
cajgh-29	319	33	among	among	ADP
cajgh-29	319	34	breast	breast	NOUN
cajgh-29	319	35	cancer	cancer	NOUN
cajgh-29	319	36	patients	patient	NOUN
cajgh-29	319	37	from	from	ADP
cajgh-29	319	38	the	the	DET
cajgh-29	319	39	philippines	philippine	NOUN
cajgh-29	319	40	.	.	PUNCT
cajgh-29	320	1	int	int	PROPN
cajgh-29	320	2	j	j	PROPN
cajgh-29	320	3	cancer	cancer	NOUN
cajgh-29	320	4	.	.	PUNCT
cajgh-29	321	1	2002	2002	NUM
cajgh-29	321	2	;	;	PUNCT
cajgh-29	322	1	98:387–480	98:387–480	NUM
cajgh-29	322	2	.	.	PUNCT
cajgh-29	323	1	38	38	NUM
cajgh-29	323	2	.	.	PUNCT
cajgh-29	324	1	han	han	PROPN
cajgh-29	324	2	sh	sh	PROPN
cajgh-29	324	3	,	,	PUNCT
cajgh-29	324	4	lee	lee	PROPN
cajgh-29	324	5	kr	kr	PROPN
cajgh-29	324	6	,	,	PUNCT
cajgh-29	324	7	lee	lee	PROPN
cajgh-29	324	8	dg	dg	PROPN
cajgh-29	324	9	,	,	PUNCT
cajgh-29	324	10	kim	kim	PROPN
cajgh-29	324	11	dy	dy	PROPN
cajgh-29	324	12	,	,	PUNCT
cajgh-29	324	13	lee	lee	PROPN
cajgh-29	324	14	ke	ke	PROPN
cajgh-29	324	15	,	,	PUNCT
cajgh-29	324	16	chung	chung	PROPN
cajgh-29	324	17	ws	ws	PROPN
cajgh-29	324	18	.	.	PUNCT
cajgh-29	325	1	mutation	mutation	NOUN
cajgh-29	325	2	analysis	analysis	NOUN
cajgh-29	325	3	of	of	ADP
cajgh-29	325	4	brca1	brca1	PROPN
cajgh-29	325	5	and	and	CCONJ
cajgh-29	325	6	brca2	brca2	NOUN
cajgh-29	325	7	from	from	ADP
cajgh-29	325	8	793	793	NUM
cajgh-29	325	9	patients	patient	NOUN
cajgh-29	325	10	with	with	ADP
cajgh-29	325	11	sporadic	sporadic	ADJ
cajgh-29	325	12	breast	breast	NOUN
cajgh-29	325	13	cancer	cancer	NOUN
cajgh-29	325	14	.	.	PUNCT
cajgh-29	326	1	clin	clin	PROPN
cajgh-29	326	2	genet	genet	PROPN
cajgh-29	326	3	.	.	PUNCT
cajgh-29	327	1	2006	2006	NUM
cajgh-29	327	2	,	,	PUNCT
cajgh-29	327	3	70:496	70:496	NOUN
cajgh-29	327	4	-	-	SYM
cajgh-29	327	5	501	501	NUM
cajgh-29	327	6	.	.	PUNCT
cajgh-29	327	7	39	39	NUM
cajgh-29	327	8	.	.	PUNCT
cajgh-29	328	1	seo	seo	PROPN
cajgh-29	328	2	jh	jh	PROPN
cajgh-29	328	3	,	,	PUNCT
cajgh-29	328	4	cho	cho	PROPN
cajgh-29	328	5	dy	dy	PROPN
cajgh-29	328	6	,	,	PUNCT
cajgh-29	328	7	ahn	ahn	PROPN
cajgh-29	328	8	sh	sh	PROPN
cajgh-29	328	9	,	,	PUNCT
cajgh-29	328	10	et	et	PROPN
cajgh-29	328	11	al	al	PROPN
cajgh-29	328	12	.	.	PROPN
cajgh-29	328	13	brca1	brca1	PROPN
cajgh-29	328	14	and	and	CCONJ
cajgh-29	328	15	brca2	brca2	PROPN
cajgh-29	328	16	germline	germline	VERB
cajgh-29	328	17	mutations	mutation	NOUN
cajgh-29	328	18	in	in	ADP
cajgh-29	328	19	korean	korean	ADJ
cajgh-29	328	20	patients	patient	NOUN
cajgh-29	328	21	with	with	ADP
cajgh-29	328	22	sporadic	sporadic	ADJ
cajgh-29	328	23	cancer	cancer	NOUN
cajgh-29	328	24	.	.	PUNCT
cajgh-29	329	1	hum	hum	PROPN
cajgh-29	329	2	mutat	mutat	PROPN
cajgh-29	329	3	.	.	PUNCT
cajgh-29	329	4	2004	2004	NUM
cajgh-29	329	5	;	;	PUNCT
cajgh-29	329	6	24:350	24:350	NUM
cajgh-29	329	7	-	-	SYM
cajgh-29	329	8	356	356	NUM
cajgh-29	329	9	.	.	PUNCT
cajgh-29	329	10	40	40	NUM
cajgh-29	329	11	.	.	PUNCT
cajgh-29	330	1	song	song	PROPN
cajgh-29	330	2	cg	cg	PROPN
cajgh-29	330	3	,	,	PUNCT
cajgh-29	330	4	hu	hu	PROPN
cajgh-29	331	1	z	z	PROPN
cajgh-29	331	2	,	,	PUNCT
cajgh-29	331	3	wu	wu	PROPN
cajgh-29	331	4	j	j	PROPN
cajgh-29	331	5	,	,	PUNCT
cajgh-29	331	6	et	et	PROPN
cajgh-29	331	7	al	al	PROPN
cajgh-29	331	8	.	.	PUNCT
cajgh-29	332	1	the	the	DET
cajgh-29	332	2	prevalence	prevalence	NOUN
cajgh-29	332	3	of	of	ADP
cajgh-29	332	4	brca1	brca1	PROPN
cajgh-29	332	5	and	and	CCONJ
cajgh-29	332	6	brca2	brca2	NOUN
cajgh-29	332	7	mutations	mutation	NOUN
cajgh-29	332	8	in	in	ADP
cajgh-29	332	9	eastern	eastern	ADJ
cajgh-29	332	10	chinese	chinese	ADJ
cajgh-29	332	11	women	woman	NOUN
cajgh-29	332	12	with	with	ADP
cajgh-29	332	13	breast	breast	NOUN
cajgh-29	332	14	cancer	cancer	NOUN
cajgh-29	332	15	.	.	PUNCT
cajgh-29	333	1	j	j	PROPN
cajgh-29	333	2	cancer	cancer	NOUN
cajgh-29	333	3	res	re	VERB
cajgh-29	333	4	clin	clin	PROPN
cajgh-29	333	5	oncol	oncol	PROPN
cajgh-29	333	6	.	.	PUNCT
cajgh-29	334	1	2006	2006	NUM
cajgh-29	334	2	;	;	PUNCT
cajgh-29	334	3	132:617–26	132:617–26	NUM
cajgh-29	334	4	.	.	PUNCT
cajgh-29	335	1	41	41	NUM
cajgh-29	335	2	.	.	PUNCT
cajgh-29	336	1	anglian	anglian	ADJ
cajgh-29	336	2	breast	breast	NOUN
cajgh-29	336	3	cancer	cancer	NOUN
cajgh-29	336	4	study	study	NOUN
cajgh-29	336	5	group	group	NOUN
cajgh-29	336	6	.	.	PUNCT
cajgh-29	337	1	prevalence	prevalence	NOUN
cajgh-29	337	2	and	and	CCONJ
cajgh-29	337	3	penetrance	penetrance	NOUN
cajgh-29	337	4	of	of	ADP
cajgh-29	337	5	brca1	brca1	PROPN
cajgh-29	337	6	and	and	CCONJ
cajgh-29	337	7	brca2	brca2	NOUN
cajgh-29	337	8	mutations	mutation	NOUN
cajgh-29	337	9	in	in	ADP
cajgh-29	337	10	a	a	DET
cajgh-29	337	11	population	population	NOUN
cajgh-29	337	12	-	-	PUNCT
cajgh-29	337	13	based	base	VERB
cajgh-29	337	14	series	series	NOUN
cajgh-29	337	15	of	of	ADP
cajgh-29	337	16	breast	breast	NOUN
cajgh-29	337	17	cancer	cancer	NOUN
cajgh-29	337	18	cases	case	NOUN
cajgh-29	337	19	.	.	PUNCT
cajgh-29	338	1	br	br	PROPN
cajgh-29	338	2	j	j	PROPN
cajgh-29	338	3	cancer	cancer	NOUN
cajgh-29	338	4	.	.	PUNCT
cajgh-29	339	1	2000	2000	NUM
cajgh-29	339	2	;	;	PUNCT
cajgh-29	339	3	83:1301	83:1301	NUM
cajgh-29	339	4	-	-	SYM
cajgh-29	339	5	1308	1308	NUM
cajgh-29	339	6	.	.	PUNCT
cajgh-29	340	1	42	42	NUM
cajgh-29	340	2	.	.	PUNCT
cajgh-29	341	1	emi	emi	PROPN
cajgh-29	341	2	m	m	PROPN
cajgh-29	341	3	,	,	PUNCT
cajgh-29	341	4	matsushima	matsushima	PROPN
cajgh-29	341	5	m	m	PROPN
cajgh-29	341	6	,	,	PUNCT
cajgh-29	341	7	katagiri	katagiri	PROPN
cajgh-29	341	8	t	t	PROPN
cajgh-29	341	9	,	,	PUNCT
cajgh-29	341	10	et	et	PROPN
cajgh-29	341	11	al	al	PROPN
cajgh-29	341	12	.	.	PROPN
cajgh-29	341	13	multiplex	multiplex	PROPN
cajgh-29	341	14	mutation	mutation	NOUN
cajgh-29	341	15	screening	screening	NOUN
cajgh-29	341	16	of	of	ADP
cajgh-29	341	17	the	the	DET
cajgh-29	341	18	brca1	brca1	PROPN
cajgh-29	341	19	gene	gene	NOUN
cajgh-29	341	20	in	in	ADP
cajgh-29	341	21	1000	1000	NUM
cajgh-29	341	22	japanese	japanese	ADJ
cajgh-29	341	23	breast	breast	NOUN
cajgh-29	341	24	cancers	cancer	NOUN
cajgh-29	341	25	.	.	PUNCT
cajgh-29	342	1	jpn	jpn	PROPN
cajgh-29	342	2	j	j	PROPN
cajgh-29	342	3	cancer	cancer	NOUN
cajgh-29	342	4	res	re	NOUN
cajgh-29	342	5	.	.	PUNCT
cajgh-29	342	6	1998	1998	NUM
cajgh-29	342	7	;	;	PUNCT
cajgh-29	342	8	89(1):12	89(1):12	NUM
cajgh-29	342	9	-	-	SYM
cajgh-29	342	10	16	16	NUM
cajgh-29	342	11	.	.	PUNCT
cajgh-29	343	1	43	43	NUM
cajgh-29	343	2	.	.	PUNCT
cajgh-29	344	1	sng	sng	PROPN
cajgh-29	344	2	jh	jh	PROPN
cajgh-29	344	3	,	,	PUNCT
cajgh-29	344	4	chang	chang	PROPN
cajgh-29	344	5	j	j	PROPN
cajgh-29	344	6	,	,	PUNCT
cajgh-29	344	7	feroze	feroze	PROPN
cajgh-29	344	8	f	f	PROPN
cajgh-29	344	9	,	,	PUNCT
cajgh-29	344	10	et	et	PROPN
cajgh-29	344	11	al	al	PROPN
cajgh-29	344	12	.	.	PUNCT
cajgh-29	345	1	the	the	DET
cajgh-29	345	2	prevalence	prevalence	NOUN
cajgh-29	345	3	of	of	ADP
cajgh-29	345	4	brca1	brca1	PROPN
cajgh-29	345	5	mutations	mutation	NOUN
cajgh-29	345	6	in	in	ADP
cajgh-29	345	7	chinese	chinese	ADJ
cajgh-29	345	8	patients	patient	NOUN
cajgh-29	345	9	with	with	ADP
cajgh-29	345	10	early	early	ADJ
cajgh-29	345	11	onset	onset	VERB
cajgh-29	345	12	breast	breast	NOUN
cajgh-29	345	13	cancer	cancer	NOUN
cajgh-29	345	14	and	and	CCONJ
cajgh-29	345	15	affected	affected	ADJ
cajgh-29	345	16	relatives	relative	NOUN
cajgh-29	345	17	.	.	PUNCT
cajgh-29	346	1	br	br	PROPN
cajgh-29	346	2	j	j	PROPN
cajgh-29	346	3	cancer	cancer	NOUN
cajgh-29	346	4	.	.	PUNCT
cajgh-29	347	1	2000	2000	NUM
cajgh-29	347	2	;	;	PUNCT
cajgh-29	347	3	82:538	82:538	NOUN
cajgh-29	347	4	-	-	SYM
cajgh-29	347	5	542	542	NUM
cajgh-29	347	6	.	.	PUNCT
cajgh-29	348	1	44	44	NUM
cajgh-29	348	2	.	.	PUNCT
cajgh-29	349	1	peto	peto	PROPN
cajgh-29	349	2	j	j	PROPN
cajgh-29	349	3	,	,	PUNCT
cajgh-29	349	4	collins	collins	PROPN
cajgh-29	349	5	n	n	PRON
cajgh-29	349	6	,	,	PUNCT
cajgh-29	349	7	barfoot	barfoot	NOUN
cajgh-29	349	8	r	r	NOUN
cajgh-29	349	9	,	,	PUNCT
cajgh-29	349	10	seal	seal	NOUN
cajgh-29	349	11	s	s	PROPN
cajgh-29	349	12	,	,	PUNCT
cajgh-29	349	13	warren	warren	PROPN
cajgh-29	349	14	w	w	PROPN
cajgh-29	349	15	,	,	PUNCT
cajgh-29	349	16	rahman	rahman	PROPN
cajgh-29	349	17	n.	n.	PROPN
cajgh-29	349	18	prevalence	prevalence	NOUN
cajgh-29	349	19	of	of	ADP
cajgh-29	349	20	brca1	brca1	PROPN
cajgh-29	349	21	and	and	CCONJ
cajgh-29	349	22	brca2	brca2	PROPN
cajgh-29	349	23	gene	gene	NOUN
cajgh-29	349	24	mutations	mutation	NOUN
cajgh-29	349	25	in	in	ADP
cajgh-29	349	26	patients	patient	NOUN
cajgh-29	349	27	with	with	ADP
cajgh-29	349	28	early	early	ADJ
cajgh-29	349	29	-	-	PUNCT
cajgh-29	349	30	onset	onset	NOUN
cajgh-29	349	31	breast	breast	NOUN
cajgh-29	349	32	cancer	cancer	NOUN
cajgh-29	349	33	.	.	PUNCT
cajgh-29	350	1	j	j	PROPN
cajgh-29	350	2	nat	nat	PROPN
cajgh-29	350	3	cancer	cancer	PROPN
cajgh-29	350	4	inst	inst	PROPN
cajgh-29	350	5	.	.	PUNCT
cajgh-29	350	6	1999	1999	NUM
cajgh-29	350	7	;	;	PUNCT
cajgh-29	350	8	91:943	91:943	NUM
cajgh-29	350	9	-	-	SYM
cajgh-29	350	10	9	9	NUM
cajgh-29	350	11	.	.	NOUN
cajgh-29	350	12	45	45	NUM
cajgh-29	350	13	.	.	PUNCT
cajgh-29	350	14	stenson	stenson	PROPN
cajgh-29	350	15	pd	pd	PROPN
cajgh-29	350	16	;	;	PUNCT
cajgh-29	350	17	mort	mort	PROPN
cajgh-29	350	18	m	m	PROPN
cajgh-29	350	19	,	,	PUNCT
cajgh-29	350	20	ball	ball	PROPN
cajgh-29	350	21	ev	ev	PROPN
cajgh-29	350	22	,	,	PUNCT
cajgh-29	350	23	howells	howells	PROPN
cajgh-29	350	24	k	k	PROPN
cajgh-29	350	25	,	,	PUNCT
cajgh-29	350	26	phillips	phillip	NOUN
cajgh-29	350	27	ad	ad	NOUN
cajgh-29	350	28	,	,	PUNCT
cajgh-29	350	29	thomas	thomas	PROPN
cajgh-29	350	30	ns	ns	PROPN
cajgh-29	350	31	,	,	PUNCT
cajgh-29	350	32	cooper	cooper	NOUN
cajgh-29	350	33	dn	dn	PROPN
cajgh-29	350	34	.	.	PUNCT
cajgh-29	351	1	the	the	DET
cajgh-29	351	2	human	human	ADJ
cajgh-29	351	3	gene	gene	NOUN
cajgh-29	351	4	mutation	mutation	NOUN
cajgh-29	351	5	database	database	NOUN
cajgh-29	351	6	:	:	PUNCT
cajgh-29	351	7	2008	2008	NUM
cajgh-29	351	8	update	update	NOUN
cajgh-29	351	9	.	.	PUNCT
cajgh-29	352	1	genome	genome	NOUN
cajgh-29	352	2	medicine	medicine	NOUN
cajgh-29	352	3	.	.	PUNCT
cajgh-29	353	1	2009	2009	NUM
cajgh-29	353	2	;	;	PUNCT
cajgh-29	353	3	1(1):13	1(1):13	NUM
cajgh-29	353	4	.	.	PUNCT
cajgh-29	354	1	46	46	NUM
cajgh-29	354	2	.	.	PUNCT
cajgh-29	354	3	akilzhanova	akilzhanova	PROPN
cajgh-29	354	4	a	a	PRON
cajgh-29	354	5	,	,	PUNCT
cajgh-29	354	6	meirmanov	meirmanov	PROPN
cajgh-29	354	7	s	s	PART
cajgh-29	354	8	,	,	PUNCT
cajgh-29	354	9	zhunussova	zhunussova	PROPN
cajgh-29	354	10	t	t	PROPN
cajgh-29	354	11	,	,	PUNCT
cajgh-29	354	12	nakashima	nakashima	PROPN
cajgh-29	354	13	m	m	PROPN
cajgh-29	354	14	,	,	PUNCT
cajgh-29	354	15	takamura	takamura	NOUN
cajgh-29	354	16	n	n	CCONJ
cajgh-29	354	17	,	,	PUNCT
cajgh-29	354	18	akanov	akanov	PROPN
cajgh-29	354	19	zh	zh	PROPN
cajgh-29	354	20	,	,	PUNCT
cajgh-29	354	21	et	et	PROPN
cajgh-29	354	22	al	al	PROPN
cajgh-29	354	23	.	.	PROPN
cajgh-29	355	1	mutational	mutational	ADJ
cajgh-29	355	2	screening	screening	NOUN
cajgh-29	355	3	of	of	ADP
cajgh-29	355	4	the	the	DET
cajgh-29	355	5	brca1	brca1	PROPN
cajgh-29	355	6	gene	gene	NOUN
cajgh-29	355	7	in	in	ADP
cajgh-29	355	8	sporadic	sporadic	ADJ
cajgh-29	355	9	breast	breast	NOUN
cajgh-29	355	10	cancer	cancer	NOUN
cajgh-29	355	11	in	in	ADP
cajgh-29	355	12	the	the	DET
cajgh-29	355	13	kazakhstan	kazakhstan	PROPN
cajgh-29	355	14	population	population	NOUN
cajgh-29	355	15	.	.	PUNCT
cajgh-29	356	1	the	the	DET
cajgh-29	356	2	breast	breast	NOUN
cajgh-29	356	3	journal	journal	NOUN
cajgh-29	356	4	.	.	PUNCT
cajgh-29	357	1	2011	2011	NUM
cajgh-29	357	2	;	;	PUNCT
cajgh-29	357	3	17(3):328–330	17(3):328–330	NUM
cajgh-29	357	4	.	.	PUNCT
cajgh-29	358	1	47	47	NUM
cajgh-29	358	2	.	.	PUNCT
cajgh-29	359	1	tommasi	tommasi	PROPN
cajgh-29	359	2	s	s	PROPN
cajgh-29	359	3	,	,	PUNCT
cajgh-29	359	4	crapolicchio	crapolicchio	VERB
cajgh-29	359	5	a	a	PRON
cajgh-29	359	6	,	,	PUNCT
cajgh-29	359	7	lacalamita	lacalamita	PROPN
cajgh-29	359	8	r	r	NOUN
cajgh-29	359	9	,	,	PUNCT
cajgh-29	359	10	et	et	PROPN
cajgh-29	359	11	al	al	PROPN
cajgh-29	359	12	.	.	PUNCT
cajgh-29	359	13	brca1	brca1	PROPN
cajgh-29	359	14	mutations	mutation	NOUN
cajgh-29	359	15	and	and	CCONJ
cajgh-29	359	16	polymorphisms	polymorphism	NOUN
cajgh-29	359	17	in	in	ADP
cajgh-29	359	18	a	a	DET
cajgh-29	359	19	hospital	hospital	NOUN
cajgh-29	359	20	-	-	PUNCT
cajgh-29	359	21	based	base	VERB
cajgh-29	359	22	consecutive	consecutive	ADJ
cajgh-29	359	23	series	series	NOUN
cajgh-29	359	24	of	of	ADP
cajgh-29	359	25	breast	breast	NOUN
cajgh-29	359	26	cancer	cancer	NOUN
cajgh-29	359	27	patients	patient	NOUN
cajgh-29	359	28	from	from	ADP
cajgh-29	359	29	apulia	apulia	PROPN
cajgh-29	359	30	,	,	PUNCT
cajgh-29	359	31	italy	italy	PROPN
cajgh-29	359	32	.	.	PUNCT
cajgh-29	360	1	mutation	mutation	NOUN
cajgh-29	360	2	research	research	NOUN
cajgh-29	360	3	.	.	PUNCT
cajgh-29	361	1	2005	2005	NUM
cajgh-29	361	2	;	;	PUNCT
cajgh-29	361	3	578:395–405	578:395–405	NUM
cajgh-29	361	4	.	.	PUNCT
cajgh-29	362	1	48	48	NUM
cajgh-29	362	2	.	.	PUNCT
cajgh-29	363	1	kim	kim	PROPN
cajgh-29	363	2	by	by	ADP
cajgh-29	363	3	,	,	PUNCT
cajgh-29	363	4	lee	lee	PROPN
cajgh-29	363	5	dg	dg	PROPN
cajgh-29	363	6	,	,	PUNCT
cajgh-29	363	7	lee	lee	PROPN
cajgh-29	363	8	kr	kr	PROPN
cajgh-29	363	9	,	,	PUNCT
cajgh-29	363	10	han	han	PROPN
cajgh-29	363	11	sh	sh	PROPN
cajgh-29	363	12	,	,	PUNCT
cajgh-29	363	13	surendran	surendran	NOUN
cajgh-29	363	14	s	s	PROPN
cajgh-29	363	15	,	,	PUNCT
cajgh-29	363	16	han	han	PROPN
cajgh-29	363	17	cw	cw	PROPN
cajgh-29	363	18	,	,	PUNCT
cajgh-29	363	19	chung	chung	PROPN
cajgh-29	363	20	n.	n.	PROPN
cajgh-29	363	21	identification	identification	NOUN
cajgh-29	363	22	of	of	ADP
cajgh-29	363	23	brca1	brca1	PROPN
cajgh-29	363	24	and	and	CCONJ
cajgh-29	363	25	brca2	brca2	NOUN
cajgh-29	363	26	mutations	mutation	NOUN
cajgh-29	363	27	from	from	ADP
cajgh-29	363	28	korean	korean	ADJ
cajgh-29	363	29	breast	breast	NOUN
cajgh-29	363	30	cancer	cancer	NOUN
cajgh-29	363	31	patients	patient	NOUN
cajgh-29	363	32	using	use	VERB
cajgh-29	363	33	denaturating	denaturate	VERB
cajgh-29	363	34	hplc	hplc	NOUN
cajgh-29	363	35	.	.	PUNCT
cajgh-29	364	1	j	j	PROPN
cajgh-29	364	2	bioch	bioch	PROPN
cajgh-29	364	3	and	and	CCONJ
cajgh-29	364	4	bioph	bioph	VERB
cajgh-29	364	5	res	re	NOUN
cajgh-29	364	6	com	com	NOUN
cajgh-29	364	7	.	.	PROPN
cajgh-29	364	8	2006	2006	NUM
cajgh-29	364	9	;	;	PUNCT
cajgh-29	364	10	349:604	349:604	PROPN
cajgh-29	364	11	-	-	SYM
cajgh-29	364	12	610	610	NUM
cajgh-29	364	13	.	.	PUNCT
cajgh-29	364	14	49	49	NUM
cajgh-29	364	15	.	.	PUNCT
cajgh-29	365	1	loizidou	loizidou	PROPN
cajgh-29	365	2	m	m	PROPN
cajgh-29	365	3	,	,	PUNCT
cajgh-29	365	4	marcou	marcou	PROPN
cajgh-29	365	5	y	y	PROPN
cajgh-29	365	6	,	,	PUNCT
cajgh-29	365	7	anastasiadou	anastasiadou	NOUN
cajgh-29	365	8	v	v	NOUN
cajgh-29	365	9	,	,	PUNCT
cajgh-29	365	10	newbold	newbold	PROPN
cajgh-29	365	11	r	r	PROPN
cajgh-29	365	12	,	,	PUNCT
cajgh-29	365	13	hadjisavvas	hadjisavvas	PROPN
cajgh-29	365	14	a	a	NOUN
cajgh-29	365	15	,	,	PUNCT
cajgh-29	365	16	kyriacou	kyriacou	PROPN
cajgh-29	365	17	k.	k.	PROPN
cajgh-29	365	18	contribution	contribution	PROPN
cajgh-29	365	19	of	of	ADP
cajgh-29	365	20	brca1	brca1	PROPN
cajgh-29	365	21	and	and	CCONJ
cajgh-29	365	22	brca2	brca2	PROPN
cajgh-29	365	23	germline	germline	VERB
cajgh-29	365	24	mutations	mutation	NOUN
cajgh-29	365	25	to	to	ADP
cajgh-29	365	26	the	the	DET
cajgh-29	365	27	incidence	incidence	NOUN
cajgh-29	365	28	of	of	ADP
cajgh-29	365	29	early	early	ADJ
cajgh-29	365	30	-	-	PUNCT
cajgh-29	365	31	onset	onset	NOUN
cajgh-29	365	32	breast	breast	NOUN
cajgh-29	365	33	cancer	cancer	NOUN
cajgh-29	365	34	in	in	ADP
cajgh-29	365	35	cyprus	cyprus	PROPN
cajgh-29	365	36	.	.	PUNCT
cajgh-29	366	1	clin	clin	PROPN
cajgh-29	366	2	genet	genet	PROPN
cajgh-29	366	3	.	.	PUNCT
cajgh-29	367	1	2007	2007	NUM
cajgh-29	367	2	;	;	PUNCT
cajgh-29	367	3	71:165	71:165	NUM
cajgh-29	367	4	-	-	SYM
cajgh-29	367	5	170	170	NUM
cajgh-29	367	6	.	.	PUNCT
cajgh-29	368	1	50	50	NUM
cajgh-29	368	2	.	.	PUNCT
cajgh-29	369	1	the	the	DET
cajgh-29	369	2	international	international	ADJ
cajgh-29	369	3	hapmap	hapmap	PROPN
cajgh-29	369	4	project	project	NOUN
cajgh-29	369	5	.	.	PUNCT
cajgh-29	370	1	nature	nature	NOUN
cajgh-29	370	2	.	.	PUNCT
cajgh-29	371	1	2003	2003	NUM
cajgh-29	371	2	;	;	PUNCT
cajgh-29	371	3	426:789–796	426:789–796	NUM
cajgh-29	371	4	.	.	PUNCT
cajgh-29	372	1	51	51	NUM
cajgh-29	372	2	.	.	PUNCT
cajgh-29	373	1	freedman	freedman	PROPN
cajgh-29	373	2	ml	ml	PROPN
cajgh-29	373	3	,	,	PUNCT
cajgh-29	373	4	penney	penney	PROPN
cajgh-29	373	5	kl	kl	PROPN
cajgh-29	373	6	,	,	PUNCT
cajgh-29	373	7	stram	stram	PROPN
cajgh-29	373	8	do	do	VERB
cajgh-29	373	9	,	,	PUNCT
cajgh-29	373	10	riley	riley	PROPN
cajgh-29	373	11	s	s	PROPN
cajgh-29	373	12	,	,	PUNCT
cajgh-29	373	13	mckean	mckean	PROPN
cajgh-29	373	14	-	-	PUNCT
cajgh-29	373	15	cowdin	cowdin	NOUN
cajgh-29	373	16	r	r	NOUN
cajgh-29	373	17	,	,	PUNCT
cajgh-29	373	18	le	le	X
cajgh-29	373	19	marchand	marchand	PROPN
cajgh-29	373	20	l	l	PROPN
cajgh-29	373	21	,	,	PUNCT
cajgh-29	373	22	altshuler	altshuler	PROPN
cajgh-29	373	23	d	d	PROPN
cajgh-29	373	24	,	,	PUNCT
cajgh-29	373	25	haiman	haiman	NOUN
cajgh-29	373	26	ca	ca	NOUN
cajgh-29	373	27	.	.	PUNCT
cajgh-29	374	1	a	a	DET
cajgh-29	374	2	haplotype	haplotype	NOUN
cajgh-29	374	3	-	-	PUNCT
cajgh-29	374	4	based	base	VERB
cajgh-29	374	5	case	case	NOUN
cajgh-29	374	6	-	-	PUNCT
cajgh-29	374	7	control	control	NOUN
cajgh-29	374	8	study	study	NOUN
cajgh-29	374	9	of	of	ADP
cajgh-29	374	10	brca1	brca1	PROPN
cajgh-29	374	11	and	and	CCONJ
cajgh-29	374	12	sporadic	sporadic	ADJ
cajgh-29	374	13	breast	breast	NOUN
cajgh-29	374	14	cancer	cancer	NOUN
cajgh-29	374	15	risk	risk	NOUN
cajgh-29	374	16	.	.	PUNCT
cajgh-29	375	1	cancer	cancer	NOUN
cajgh-29	375	2	res	re	NOUN
cajgh-29	375	3	.	.	PUNCT
cajgh-29	375	4	2005	2005	NUM
cajgh-29	375	5	;	;	PUNCT
cajgh-29	375	6	65(16):7516	65(16):7516	NUM
cajgh-29	375	7	-	-	SYM
cajgh-29	375	8	7522	7522	NUM
cajgh-29	375	9	.	.	PUNCT
cajgh-29	376	1	52	52	NUM
cajgh-29	376	2	.	.	PUNCT
cajgh-29	377	1	freedman	freedman	PROPN
cajgh-29	377	2	ml	ml	PROPN
cajgh-29	377	3	,	,	PUNCT
cajgh-29	377	4	penney	penney	PROPN
cajgh-29	377	5	kl	kl	PROPN
cajgh-29	377	6	,	,	PUNCT
cajgh-29	377	7	stram	stram	PROPN
cajgh-29	377	8	do	do	VERB
cajgh-29	377	9	,	,	PUNCT
cajgh-29	377	10	et	et	PROPN
cajgh-29	377	11	al	al	PROPN
cajgh-29	377	12	.	.	PROPN
cajgh-29	378	1	common	common	ADJ
cajgh-29	378	2	variation	variation	NOUN
cajgh-29	378	3	in	in	ADP
cajgh-29	378	4	brca2	brca2	PROPN
cajgh-29	378	5	and	and	CCONJ
cajgh-29	378	6	breast	breast	NOUN
cajgh-29	378	7	cancer	cancer	NOUN
cajgh-29	378	8	risk	risk	NOUN
cajgh-29	378	9	:	:	PUNCT
cajgh-29	378	10	a	a	DET
cajgh-29	378	11	haplotype	haplotype	NOUN
cajgh-29	378	12	based	base	VERB
cajgh-29	378	13	analysis	analysis	NOUN
cajgh-29	378	14	in	in	ADP
cajgh-29	378	15	the	the	DET
cajgh-29	378	16	multiethnic	multiethnic	ADJ
cajgh-29	378	17	cohort	cohort	NOUN
cajgh-29	378	18	.	.	PUNCT
cajgh-29	379	1	hum	hum	PROPN
cajgh-29	379	2	mol	mol	ADP
cajgh-29	379	3	genet	genet	PROPN
cajgh-29	379	4	.	.	PUNCT
cajgh-29	380	1	2004	2004	NUM
cajgh-29	380	2	;	;	PUNCT
cajgh-29	380	3	13:2431–2441	13:2431–2441	NUM
cajgh-29	380	4	.	.	PUNCT
cajgh-29	381	1	53	53	NUM
cajgh-29	381	2	.	.	PUNCT
cajgh-29	381	3	cox	cox	PROPN
cajgh-29	381	4	dg	dg	PROPN
cajgh-29	381	5	,	,	PUNCT
cajgh-29	381	6	kraft	kraft	NOUN
cajgh-29	381	7	p	p	NOUN
cajgh-29	381	8	,	,	PUNCT
cajgh-29	381	9	hankinson	hankinson	PROPN
cajgh-29	381	10	se	se	PROPN
cajgh-29	381	11	,	,	PUNCT
cajgh-29	381	12	hunter	hunter	NOUN
cajgh-29	381	13	dj	dj	PROPN
cajgh-29	381	14	.	.	PROPN
cajgh-29	381	15	haplotype	haplotype	NOUN
cajgh-29	381	16	analysis	analysis	NOUN
cajgh-29	381	17	of	of	ADP
cajgh-29	381	18	common	common	ADJ
cajgh-29	381	19	variants	variant	NOUN
cajgh-29	381	20	in	in	ADP
cajgh-29	381	21	the	the	DET
cajgh-29	381	22	brca1	brca1	PROPN
cajgh-29	381	23	gene	gene	NOUN
cajgh-29	381	24	and	and	CCONJ
cajgh-29	381	25	risk	risk	NOUN
cajgh-29	381	26	of	of	ADP
cajgh-29	381	27	sporadic	sporadic	ADJ
cajgh-29	381	28	breast	breast	NOUN
cajgh-29	381	29	cancer	cancer	NOUN
cajgh-29	381	30	.	.	PUNCT
cajgh-29	382	1	breast	breast	NOUN
cajgh-29	382	2	cancer	cancer	NOUN
cajgh-29	382	3	res	re	NOUN
cajgh-29	382	4	.	.	PUNCT
cajgh-29	382	5	2005	2005	NUM
cajgh-29	382	6	;	;	PUNCT
cajgh-29	382	7	7	7	NUM
cajgh-29	382	8	:	:	PUNCT
cajgh-29	382	9	r171–175	r171–175	ADJ
cajgh-29	382	10	.	.	PUNCT
cajgh-29	383	1	54	54	NUM
cajgh-29	383	2	.	.	PUNCT
cajgh-29	384	1	bowcock	bowcock	NOUN
cajgh-29	384	2	am	be	AUX
cajgh-29	384	3	,	,	PUNCT
cajgh-29	384	4	kidd	kidd	PROPN
cajgh-29	384	5	jr	jr	PROPN
cajgh-29	384	6	,	,	PUNCT
cajgh-29	384	7	mountain	mountain	PROPN
cajgh-29	384	8	jl	jl	PROPN
cajgh-29	384	9	,	,	PUNCT
cajgh-29	384	10	et	et	PROPN
cajgh-29	384	11	al	al	PROPN
cajgh-29	384	12	.	.	PROPN
cajgh-29	384	13	drift	drift	PROPN
cajgh-29	384	14	,	,	PUNCT
cajgh-29	384	15	admixture	admixture	NOUN
cajgh-29	384	16	,	,	PUNCT
cajgh-29	384	17	and	and	CCONJ
cajgh-29	384	18	selection	selection	NOUN
cajgh-29	384	19	in	in	ADP
cajgh-29	384	20	human	human	ADJ
cajgh-29	384	21	evolution	evolution	NOUN
cajgh-29	384	22	:	:	PUNCT
cajgh-29	384	23	a	a	DET
cajgh-29	384	24	study	study	NOUN
cajgh-29	384	25	with	with	ADP
cajgh-29	384	26	dna	dna	PROPN
cajgh-29	384	27	polymorphisms	polymorphism	NOUN
cajgh-29	384	28	.	.	PUNCT
cajgh-29	385	1	proc	proc	PROPN
cajgh-29	385	2	natl	natl	PROPN
cajgh-29	385	3	acad	acad	PROPN
cajgh-29	385	4	sci	sci	PROPN
cajgh-29	385	5	usa	usa	PROPN
cajgh-29	385	6	.	.	PROPN
cajgh-29	385	7	1991	1991	NUM
cajgh-29	385	8	;	;	PUNCT
cajgh-29	385	9	88:839–843	88:839–843	NUM
cajgh-29	385	10	.	.	PUNCT
cajgh-29	386	1	55	55	NUM
cajgh-29	386	2	.	.	X
cajgh-29	387	1	pike	pike	PROPN
cajgh-29	387	2	mc	mc	PROPN
cajgh-29	387	3	,	,	PUNCT
cajgh-29	387	4	kolonel	kolonel	PROPN
cajgh-29	387	5	ln	ln	PROPN
cajgh-29	387	6	,	,	PUNCT
cajgh-29	387	7	henderson	henderson	PROPN
cajgh-29	387	8	be	be	PROPN
cajgh-29	387	9	,	,	PUNCT
cajgh-29	387	10	et	et	PROPN
cajgh-29	387	11	al	al	PROPN
cajgh-29	387	12	.	.	PUNCT
cajgh-29	387	13	breast	breast	NOUN
cajgh-29	387	14	cancer	cancer	NOUN
cajgh-29	387	15	in	in	ADP
cajgh-29	387	16	a	a	DET
cajgh-29	387	17	multiethnic	multiethnic	ADJ
cajgh-29	387	18	cohort	cohort	NOUN
cajgh-29	387	19	in	in	ADP
cajgh-29	387	20	hawaii	hawaii	PROPN
cajgh-29	387	21	and	and	CCONJ
cajgh-29	387	22	los	los	PROPN
cajgh-29	387	23	angeles	angeles	PROPN
cajgh-29	387	24	:	:	PUNCT
cajgh-29	387	25	risk	risk	NOUN
cajgh-29	387	26	factor	factor	NOUN
cajgh-29	387	27	-	-	PUNCT
cajgh-29	387	28	adjusted	adjust	VERB
cajgh-29	387	29	incidence	incidence	NOUN
cajgh-29	387	30	in	in	ADP
cajgh-29	387	31	japanese	japanese	PROPN
cajgh-29	387	32	equals	equal	VERB
cajgh-29	387	33	and	and	CCONJ
cajgh-29	387	34	in	in	ADP
cajgh-29	387	35	hawaiians	hawaiian	NOUN
cajgh-29	387	36	exceeds	exceed	VERB
cajgh-29	387	37	that	that	SCONJ
cajgh-29	387	38	in	in	ADP
cajgh-29	387	39	whites	white	NOUN
cajgh-29	387	40	.	.	PUNCT
cajgh-29	388	1	cancer	cancer	NOUN
cajgh-29	388	2	epidemiol	epidemiol	PROPN
cajgh-29	388	3	biomarkers	biomarkers	PROPN
cajgh-29	388	4	prev	prev	X
cajgh-29	388	5	.	.	PUNCT
cajgh-29	389	1	2002	2002	NUM
cajgh-29	389	2	;	;	PUNCT
cajgh-29	389	3	11:795–800	11:795–800	NUM
cajgh-29	389	4	.	.	PUNCT
cajgh-29	390	1	56	56	NUM
cajgh-29	390	2	.	.	PUNCT
cajgh-29	391	1	sachidanandam	sachidanandam	PROPN
cajgh-29	391	2	r	r	PROPN
cajgh-29	391	3	,	,	PUNCT
cajgh-29	391	4	weissman	weissman	PROPN
cajgh-29	391	5	d	d	PROPN
cajgh-29	391	6	,	,	PUNCT
cajgh-29	391	7	schmidt	schmidt	PROPN
cajgh-29	391	8	sc	sc	PROPN
cajgh-29	391	9	,	,	PUNCT
cajgh-29	391	10	et	et	PROPN
cajgh-29	391	11	al	al	PROPN
cajgh-29	391	12	.	.	PUNCT
cajgh-29	392	1	a	a	DET
cajgh-29	392	2	map	map	NOUN
cajgh-29	392	3	of	of	ADP
cajgh-29	392	4	human	human	ADJ
cajgh-29	392	5	genome	genome	NOUN
cajgh-29	392	6	sequence	sequence	NOUN
cajgh-29	392	7	variation	variation	NOUN
cajgh-29	392	8	containing	contain	VERB
cajgh-29	392	9	1.42	1.42	NUM
cajgh-29	392	10	million	million	NUM
cajgh-29	392	11	single	single	ADJ
cajgh-29	392	12	nucleotide	nucleotide	NOUN
cajgh-29	392	13	polymorphisms	polymorphism	NOUN
cajgh-29	392	14	.	.	PUNCT
cajgh-29	393	1	nature	nature	NOUN
cajgh-29	393	2	.	.	PUNCT
cajgh-29	394	1	2001	2001	NUM
cajgh-29	394	2	;	;	PUNCT
cajgh-29	394	3	409:928–933	409:928–933	NUM
cajgh-29	394	4	.	.	PUNCT
cajgh-29	395	1	57	57	NUM
cajgh-29	395	2	.	.	PUNCT
cajgh-29	395	3	sorlie	sorlie	PROPN
cajgh-29	395	4	t	t	PROPN
cajgh-29	395	5	,	,	PUNCT
cajgh-29	395	6	tibshirani	tibshirani	PROPN
cajgh-29	395	7	r	r	NOUN
cajgh-29	395	8	,	,	PUNCT
cajgh-29	395	9	parker	parker	PROPN
cajgh-29	395	10	j	j	PROPN
cajgh-29	395	11	,	,	PUNCT
cajgh-29	395	12	et	et	PROPN
cajgh-29	396	1	al	al	PROPN
cajgh-29	396	2	.	.	PROPN
cajgh-29	396	3	repeated	repeat	VERB
cajgh-29	396	4	observation	observation	NOUN
cajgh-29	396	5	of	of	ADP
cajgh-29	396	6	breast	breast	NOUN
cajgh-29	396	7	tumor	tumor	NOUN
cajgh-29	396	8	subtypes	subtype	NOUN
cajgh-29	396	9	in	in	ADP
cajgh-29	396	10	independent	independent	ADJ
cajgh-29	396	11	gene	gene	NOUN
cajgh-29	396	12	expression	expression	NOUN
cajgh-29	396	13	data	datum	NOUN
cajgh-29	396	14	sets	set	NOUN
cajgh-29	396	15	.	.	PUNCT
cajgh-29	397	1	proc	proc	PROPN
cajgh-29	397	2	natl	natl	PROPN
cajgh-29	397	3	acad	acad	PROPN
cajgh-29	397	4	sci	sci	PROPN
cajgh-29	397	5	usa	usa	PROPN
cajgh-29	397	6	.	.	PROPN
cajgh-29	397	7	2003	2003	NUM
cajgh-29	397	8	;	;	PUNCT
cajgh-29	397	9	100:8418–8423	100:8418–8423	NUM
cajgh-29	397	10	.	.	PUNCT
cajgh-29	398	1	58	58	NUM
cajgh-29	398	2	.	.	PUNCT
cajgh-29	399	1	foulkes	foulkes	PROPN
cajgh-29	399	2	wd	wd	PROPN
cajgh-29	399	3	,	,	PUNCT
cajgh-29	399	4	stefansson	stefansson	PROPN
cajgh-29	399	5	i	i	PRON
cajgh-29	399	6	m	m	PROPN
cajgh-29	399	7	,	,	PUNCT
cajgh-29	399	8	chappuis	chappuis	PROPN
cajgh-29	399	9	po	po	PROPN
cajgh-29	399	10	,	,	PUNCT
cajgh-29	399	11	et	et	PROPN
cajgh-29	399	12	al	al	PROPN
cajgh-29	399	13	.	.	PROPN
cajgh-29	399	14	germline	germline	PROPN
cajgh-29	399	15	brca1	brca1	PROPN
cajgh-29	399	16	mutations	mutation	NOUN
cajgh-29	399	17	and	and	CCONJ
cajgh-29	399	18	a	a	DET
cajgh-29	399	19	basal	basal	ADJ
cajgh-29	399	20	epithelial	epithelial	ADJ
cajgh-29	399	21	phenotype	phenotype	NOUN
cajgh-29	399	22	in	in	ADP
cajgh-29	399	23	breast	breast	NOUN
cajgh-29	399	24	cancer	cancer	NOUN
cajgh-29	399	25	.	.	PUNCT
cajgh-29	400	1	j	j	PROPN
cajgh-29	400	2	natl	natl	PROPN
cajgh-29	400	3	cancer	cancer	PROPN
cajgh-29	400	4	inst	inst	PROPN
cajgh-29	400	5	.	.	PROPN
cajgh-29	400	6	2003	2003	NUM
cajgh-29	400	7	;	;	PUNCT
cajgh-29	401	1	95:1482–1485	95:1482–1485	NUM
cajgh-29	401	2	.	.	X
cajgh-29	402	1	59	59	NUM
cajgh-29	402	2	.	.	PUNCT
cajgh-29	402	3	turner	turner	PROPN
cajgh-29	402	4	n	n	PROPN
cajgh-29	402	5	,	,	PUNCT
cajgh-29	402	6	tutt	tutt	PROPN
cajgh-29	402	7	a	a	X
cajgh-29	402	8	,	,	PUNCT
cajgh-29	402	9	ashworth	ashworth	PROPN
cajgh-29	402	10	a.	a.	NOUN
cajgh-29	402	11	hallmarks	hallmark	NOUN
cajgh-29	402	12	of	of	ADP
cajgh-29	402	13	‘	'	PUNCT
cajgh-29	402	14	‘	'	PUNCT
cajgh-29	402	15	brcaness	brcaness	NOUN
cajgh-29	402	16	’’	’'	PUNCT
cajgh-29	402	17	in	in	ADP
cajgh-29	402	18	sporadic	sporadic	ADJ
cajgh-29	402	19	cancers	cancer	NOUN
cajgh-29	402	20	.	.	PUNCT
cajgh-29	403	1	nat	nat	PROPN
cajgh-29	403	2	rev	rev	PROPN
cajgh-29	403	3	cancer	cancer	NOUN
cajgh-29	403	4	.	.	PUNCT
cajgh-29	404	1	2004	2004	NUM
cajgh-29	404	2	;	;	PUNCT
cajgh-29	404	3	4:814–819	4:814–819	NOUN
cajgh-29	404	4	.	.	PUNCT