id	sid	tid	token	lemma	pos
cajgh-4	1	1	effects	effect	NOUN
cajgh-4	1	2	of	of	ADP
cajgh-4	1	3	amyloid	amyloid	NOUN
cajgh-4	1	4	beta	beta	ADJ
cajgh-4	1	5	peptide	peptide	NOUN
cajgh-4	1	6	on	on	ADP
cajgh-4	1	7	neurovascular	neurovascular	ADJ
cajgh-4	1	8	cells	cell	NOUN
cajgh-4	1	9	effects	effect	NOUN
cajgh-4	1	10	of	of	ADP
cajgh-4	1	11	amyloid	amyloid	NOUN
cajgh-4	1	12	beta	beta	ADJ
cajgh-4	1	13	peptide	peptide	NOUN
cajgh-4	1	14	on	on	ADP
cajgh-4	1	15	neurovascular	neurovascular	ADJ
cajgh-4	1	16	cells	cell	NOUN
cajgh-4	1	17	sholpan	sholpan	ADJ
cajgh-4	1	18	askarova1	askarova1	PROPN
cajgh-4	1	19	,	,	PUNCT
cajgh-4	1	20	andrey	andrey	PROPN
cajgh-4	1	21	tsoy1,2	tsoy1,2	PROPN
cajgh-4	1	22	,	,	PUNCT
cajgh-4	1	23	tamara	tamara	PROPN
cajgh-4	1	24	shalakhmetova2	shalakhmetova2	PROPN
cajgh-4	1	25	,	,	PUNCT
cajgh-4	1	26	james	james	PROPN
cajgh-4	1	27	c	c	PROPN
cajgh-4	1	28	-	-	PUNCT
cajgh-4	1	29	m	m	PROPN
cajgh-4	1	30	lee3	lee3	PROPN
cajgh-4	1	31	1nazarbayev	1nazarbayev	NUM
cajgh-4	1	32	university	university	NOUN
cajgh-4	1	33	,	,	PUNCT
cajgh-4	1	34	center	center	NOUN
cajgh-4	1	35	for	for	ADP
cajgh-4	1	36	life	life	NOUN
cajgh-4	1	37	sciences	science	NOUN
cajgh-4	1	38	,	,	PUNCT
cajgh-4	1	39	astana	astana	PROPN
cajgh-4	1	40	,	,	PUNCT
cajgh-4	1	41	kazakhstan	kazakhstan	PROPN
cajgh-4	1	42	;	;	PUNCT
cajgh-4	1	43	2al	2al	ADJ
cajgh-4	1	44	-	-	PUNCT
cajgh-4	1	45	farabi	farabi	PROPN
cajgh-4	1	46	kazakh	kazakh	PROPN
cajgh-4	1	47	national	national	PROPN
cajgh-4	1	48	university	university	PROPN
cajgh-4	1	49	,	,	PUNCT
cajgh-4	1	50	biology	biology	NOUN
cajgh-4	1	51	faculty	faculty	NOUN
cajgh-4	1	52	,	,	PUNCT
cajgh-4	1	53	almaty	almaty	PROPN
cajgh-4	1	54	,	,	PUNCT
cajgh-4	1	55	kazakhstan	kazakhstan	PROPN
cajgh-4	1	56	;	;	PUNCT
cajgh-4	1	57	3department	3department	NUM
cajgh-4	1	58	of	of	ADP
cajgh-4	1	59	biological	biological	ADJ
cajgh-4	1	60	engineering	engineering	NOUN
cajgh-4	1	61	,	,	PUNCT
cajgh-4	1	62	university	university	PROPN
cajgh-4	1	63	of	of	ADP
cajgh-4	1	64	missouri	missouri	PROPN
cajgh-4	1	65	,	,	PUNCT
cajgh-4	1	66	columbia	columbia	PROPN
cajgh-4	1	67	,	,	PUNCT
cajgh-4	1	68	mo	mo	PROPN
cajgh-4	1	69	abstract	abstract	PROPN
cajgh-4	1	70	alzheimer	alzheimer	PROPN
cajgh-4	1	71	’s	’s	PART
cajgh-4	1	72	disease	disease	NOUN
cajgh-4	1	73	(	(	PUNCT
cajgh-4	1	74	ad	ad	NOUN
cajgh-4	1	75	)	)	PUNCT
cajgh-4	1	76	is	be	AUX
cajgh-4	1	77	a	a	DET
cajgh-4	1	78	chronic	chronic	ADJ
cajgh-4	1	79	neurodegenerative	neurodegenerative	ADJ
cajgh-4	1	80	disorder	disorder	NOUN
cajgh-4	1	81	,	,	PUNCT
cajgh-4	1	82	which	which	PRON
cajgh-4	1	83	is	be	AUX
cajgh-4	1	84	characterized	characterize	VERB
cajgh-4	1	85	by	by	ADP
cajgh-4	1	86	the	the	DET
cajgh-4	1	87	accumulation	accumulation	NOUN
cajgh-4	1	88	of	of	ADP
cajgh-4	1	89	amyloid	amyloid	NOUN
cajgh-4	1	90	plaques	plaque	NOUN
cajgh-4	1	91	and	and	CCONJ
cajgh-4	1	92	neurofibrillary	neurofibrillary	ADJ
cajgh-4	1	93	tangles	tangle	NOUN
cajgh-4	1	94	in	in	ADP
cajgh-4	1	95	specific	specific	ADJ
cajgh-4	1	96	regions	region	NOUN
cajgh-4	1	97	of	of	ADP
cajgh-4	1	98	the	the	DET
cajgh-4	1	99	brain	brain	NOUN
cajgh-4	1	100	,	,	PUNCT
cajgh-4	1	101	accompanied	accompany	VERB
cajgh-4	1	102	by	by	ADP
cajgh-4	1	103	impairment	impairment	NOUN
cajgh-4	1	104	of	of	ADP
cajgh-4	1	105	the	the	DET
cajgh-4	1	106	neurons	neuron	NOUN
cajgh-4	1	107	,	,	PUNCT
cajgh-4	1	108	and	and	CCONJ
cajgh-4	1	109	progressive	progressive	ADJ
cajgh-4	1	110	deterioration	deterioration	NOUN
cajgh-4	1	111	of	of	ADP
cajgh-4	1	112	cognition	cognition	NOUN
cajgh-4	1	113	and	and	CCONJ
cajgh-4	1	114	memory	memory	NOUN
cajgh-4	1	115	of	of	ADP
cajgh-4	1	116	affected	affected	ADJ
cajgh-4	1	117	individuals	individual	NOUN
cajgh-4	1	118	.	.	PUNCT
cajgh-4	2	1	although	although	SCONJ
cajgh-4	2	2	the	the	DET
cajgh-4	2	3	cause	cause	NOUN
cajgh-4	2	4	and	and	CCONJ
cajgh-4	2	5	progression	progression	NOUN
cajgh-4	2	6	of	of	ADP
cajgh-4	2	7	ad	ad	NOUN
cajgh-4	2	8	are	be	AUX
cajgh-4	2	9	still	still	ADV
cajgh-4	2	10	not	not	PART
cajgh-4	2	11	well	well	ADV
cajgh-4	2	12	understood	understand	VERB
cajgh-4	2	13	,	,	PUNCT
cajgh-4	2	14	the	the	DET
cajgh-4	2	15	amyloid	amyloid	NOUN
cajgh-4	2	16	hypothesis	hypothesis	NOUN
cajgh-4	2	17	is	be	AUX
cajgh-4	2	18	dominant	dominant	ADJ
cajgh-4	2	19	and	and	CCONJ
cajgh-4	2	20	widely	widely	ADV
cajgh-4	2	21	accepted	accept	VERB
cajgh-4	2	22	.	.	PUNCT
cajgh-4	3	1	according	accord	VERB
cajgh-4	3	2	to	to	ADP
cajgh-4	3	3	this	this	DET
cajgh-4	3	4	hypothesis	hypothesis	NOUN
cajgh-4	3	5	,	,	PUNCT
cajgh-4	3	6	an	an	DET
cajgh-4	3	7	increased	increase	VERB
cajgh-4	3	8	deposition	deposition	NOUN
cajgh-4	3	9	of	of	ADP
cajgh-4	3	10	amyloid	amyloid	NOUN
cajgh-4	3	11	-	-	PUNCT
cajgh-4	3	12	β	β	X
cajgh-4	3	13	peptide	peptide	NOUN
cajgh-4	3	14	(	(	PUNCT
cajgh-4	3	15	aβ	aβ	NOUN
cajgh-4	3	16	)	)	PUNCT
cajgh-4	3	17	in	in	ADP
cajgh-4	3	18	the	the	DET
cajgh-4	3	19	brain	brain	NOUN
cajgh-4	3	20	is	be	AUX
cajgh-4	3	21	the	the	DET
cajgh-4	3	22	main	main	ADJ
cajgh-4	3	23	cause	cause	NOUN
cajgh-4	3	24	of	of	ADP
cajgh-4	3	25	the	the	DET
cajgh-4	3	26	ad	ad	NOUN
cajgh-4	3	27	’s	’s	PART
cajgh-4	3	28	onset	onset	NOUN
cajgh-4	3	29	and	and	CCONJ
cajgh-4	3	30	progression	progression	NOUN
cajgh-4	3	31	.	.	PUNCT
cajgh-4	4	1	there	there	PRON
cajgh-4	4	2	is	be	VERB
cajgh-4	4	3	increasing	increase	VERB
cajgh-4	4	4	body	body	NOUN
cajgh-4	4	5	of	of	ADP
cajgh-4	4	6	evidence	evidence	NOUN
cajgh-4	4	7	that	that	SCONJ
cajgh-4	4	8	blood	blood	NOUN
cajgh-4	4	9	-	-	PUNCT
cajgh-4	4	10	brain	brain	NOUN
cajgh-4	4	11	barrier	barrier	NOUN
cajgh-4	4	12	(	(	PUNCT
cajgh-4	4	13	bbb	bbb	NOUN
cajgh-4	4	14	)	)	PUNCT
cajgh-4	4	15	dysfunction	dysfunction	NOUN
cajgh-4	4	16	plays	play	VERB
cajgh-4	4	17	an	an	DET
cajgh-4	4	18	important	important	ADJ
cajgh-4	4	19	role	role	NOUN
cajgh-4	4	20	in	in	ADP
cajgh-4	4	21	the	the	DET
cajgh-4	4	22	development	development	NOUN
cajgh-4	4	23	of	of	ADP
cajgh-4	4	24	ad	ad	NOUN
cajgh-4	4	25	,	,	PUNCT
cajgh-4	4	26	and	and	CCONJ
cajgh-4	4	27	may	may	AUX
cajgh-4	4	28	even	even	ADV
cajgh-4	4	29	precede	precede	VERB
cajgh-4	4	30	neuron	neuron	NOUN
cajgh-4	4	31	degeneration	degeneration	NOUN
cajgh-4	4	32	in	in	ADP
cajgh-4	4	33	ad	ad	NOUN
cajgh-4	4	34	brain	brain	NOUN
cajgh-4	4	35	.	.	PUNCT
cajgh-4	5	1	in	in	ADP
cajgh-4	5	2	the	the	DET
cajgh-4	5	3	early	early	ADJ
cajgh-4	5	4	stage	stage	NOUN
cajgh-4	5	5	of	of	ADP
cajgh-4	5	6	ad	ad	NOUN
cajgh-4	5	7	,	,	PUNCT
cajgh-4	5	8	microvasculature	microvasculature	NOUN
cajgh-4	5	9	deficiencies	deficiency	NOUN
cajgh-4	5	10	,	,	PUNCT
cajgh-4	5	11	inflammatory	inflammatory	ADJ
cajgh-4	5	12	reactions	reaction	NOUN
cajgh-4	5	13	,	,	PUNCT
cajgh-4	5	14	surrounding	surround	VERB
cajgh-4	5	15	the	the	DET
cajgh-4	5	16	cerebral	cerebral	ADJ
cajgh-4	5	17	vasculature	vasculature	NOUN
cajgh-4	5	18	and	and	CCONJ
cajgh-4	5	19	endothelial	endothelial	ADJ
cajgh-4	5	20	dysfunctions	dysfunction	NOUN
cajgh-4	5	21	are	be	AUX
cajgh-4	5	22	commonly	commonly	ADV
cajgh-4	5	23	observed	observe	VERB
cajgh-4	5	24	.	.	PUNCT
cajgh-4	6	1	continuous	continuous	ADJ
cajgh-4	6	2	neurovascular	neurovascular	ADJ
cajgh-4	6	3	degeneration	degeneration	NOUN
cajgh-4	6	4	and	and	CCONJ
cajgh-4	6	5	accumulation	accumulation	NOUN
cajgh-4	6	6	of	of	ADP
cajgh-4	6	7	aβ	aβ	NOUN
cajgh-4	6	8	on	on	ADP
cajgh-4	6	9	blood	blood	NOUN
cajgh-4	6	10	vessels	vessel	NOUN
cajgh-4	6	11	resulting	result	VERB
cajgh-4	6	12	in	in	ADP
cajgh-4	6	13	cerebral	cerebral	ADJ
cajgh-4	6	14	amyloid	amyloid	NOUN
cajgh-4	6	15	angiopathy	angiopathy	NOUN
cajgh-4	6	16	is	be	AUX
cajgh-4	6	17	associated	associate	VERB
cajgh-4	6	18	with	with	ADP
cajgh-4	6	19	further	further	ADJ
cajgh-4	6	20	progression	progression	NOUN
cajgh-4	6	21	of	of	ADP
cajgh-4	6	22	the	the	DET
cajgh-4	6	23	disease	disease	NOUN
cajgh-4	6	24	and	and	CCONJ
cajgh-4	6	25	cognitive	cognitive	ADJ
cajgh-4	6	26	decline	decline	NOUN
cajgh-4	6	27	.	.	PUNCT
cajgh-4	7	1	however	however	ADV
cajgh-4	7	2	,	,	PUNCT
cajgh-4	7	3	little	little	ADJ
cajgh-4	7	4	is	be	AUX
cajgh-4	7	5	known	know	VERB
cajgh-4	7	6	about	about	ADP
cajgh-4	7	7	molecular	molecular	ADJ
cajgh-4	7	8	mechanisms	mechanism	NOUN
cajgh-4	7	9	that	that	PRON
cajgh-4	7	10	underlie	underlie	VERB
cajgh-4	7	11	aβ	aβ	DET
cajgh-4	7	12	induced	induced	ADJ
cajgh-4	7	13	damage	damage	NOUN
cajgh-4	7	14	of	of	ADP
cajgh-4	7	15	neurovascular	neurovascular	ADJ
cajgh-4	7	16	cells	cell	NOUN
cajgh-4	7	17	.	.	PUNCT
cajgh-4	8	1	in	in	ADP
cajgh-4	8	2	this	this	DET
cajgh-4	8	3	regards	regard	NOUN
cajgh-4	8	4	,	,	PUNCT
cajgh-4	8	5	this	this	DET
cajgh-4	8	6	review	review	NOUN
cajgh-4	8	7	is	be	AUX
cajgh-4	8	8	aimed	aim	VERB
cajgh-4	8	9	to	to	PART
cajgh-4	8	10	address	address	VERB
cajgh-4	8	11	how	how	SCONJ
cajgh-4	8	12	aβ	aβ	NOUN
cajgh-4	8	13	impacts	impact	VERB
cajgh-4	8	14	the	the	DET
cajgh-4	8	15	cerebral	cerebral	ADJ
cajgh-4	8	16	endothelium	endothelium	NOUN
cajgh-4	8	17	.	.	PUNCT
cajgh-4	9	1	understanding	understand	VERB
cajgh-4	9	2	the	the	DET
cajgh-4	9	3	cellular	cellular	ADJ
cajgh-4	9	4	pathways	pathway	NOUN
cajgh-4	9	5	triggered	trigger	VERB
cajgh-4	9	6	by	by	ADP
cajgh-4	9	7	aβ	aβ	NOUN
cajgh-4	9	8	leading	lead	VERB
cajgh-4	9	9	to	to	ADP
cajgh-4	9	10	alterations	alteration	NOUN
cajgh-4	9	11	in	in	ADP
cajgh-4	9	12	cerebral	cerebral	ADJ
cajgh-4	9	13	endothelial	endothelial	ADJ
cajgh-4	9	14	cells	cell	NOUN
cajgh-4	9	15	structure	structure	NOUN
cajgh-4	9	16	and	and	CCONJ
cajgh-4	9	17	functions	function	NOUN
cajgh-4	9	18	would	would	AUX
cajgh-4	9	19	provide	provide	VERB
cajgh-4	9	20	insights	insight	NOUN
cajgh-4	9	21	into	into	ADP
cajgh-4	9	22	the	the	DET
cajgh-4	9	23	mechanism	mechanism	NOUN
cajgh-4	9	24	of	of	ADP
cajgh-4	9	25	bbb	bbb	PROPN
cajgh-4	9	26	dysfunction	dysfunction	NOUN
cajgh-4	9	27	and	and	CCONJ
cajgh-4	9	28	inflammatory	inflammatory	ADJ
cajgh-4	9	29	processes	process	NOUN
cajgh-4	9	30	in	in	ADP
cajgh-4	9	31	alzheimer	alzheimer	PROPN
cajgh-4	9	32	’s	’s	PART
cajgh-4	9	33	,	,	PUNCT
cajgh-4	9	34	and	and	CCONJ
cajgh-4	9	35	may	may	AUX
cajgh-4	9	36	offer	offer	VERB
cajgh-4	9	37	new	new	ADJ
cajgh-4	9	38	approaches	approach	NOUN
cajgh-4	9	39	for	for	ADP
cajgh-4	9	40	prevention	prevention	NOUN
cajgh-4	9	41	and	and	CCONJ
cajgh-4	9	42	treatment	treatment	NOUN
cajgh-4	9	43	strategies	strategy	NOUN
cajgh-4	9	44	for	for	ADP
cajgh-4	9	45	ad	ad	NOUN
cajgh-4	9	46	.	.	PUNCT
cajgh-4	10	1	introduction	introduction	NOUN
cajgh-4	10	2	alzheimer	alzheimer	PROPN
cajgh-4	10	3	’s	’s	PART
cajgh-4	10	4	disease	disease	NOUN
cajgh-4	10	5	is	be	AUX
cajgh-4	10	6	a	a	DET
cajgh-4	10	7	chronic	chronic	ADJ
cajgh-4	10	8	neurodegenerative	neurodegenerative	ADJ
cajgh-4	10	9	disorder	disorder	NOUN
cajgh-4	10	10	,	,	PUNCT
cajgh-4	10	11	which	which	PRON
cajgh-4	10	12	affects	affect	VERB
cajgh-4	10	13	approximately	approximately	ADV
cajgh-4	10	14	10	10	NUM
cajgh-4	10	15	%	%	NOUN
cajgh-4	10	16	of	of	ADP
cajgh-4	10	17	the	the	DET
cajgh-4	10	18	population	population	NOUN
cajgh-4	10	19	at	at	ADP
cajgh-4	10	20	age	age	NOUN
cajgh-4	10	21	65	65	NUM
cajgh-4	10	22	and	and	CCONJ
cajgh-4	10	23	40	40	NUM
cajgh-4	10	24	%	%	NOUN
cajgh-4	10	25	of	of	ADP
cajgh-4	10	26	people	people	NOUN
cajgh-4	10	27	over	over	ADP
cajgh-4	10	28	the	the	DET
cajgh-4	10	29	age	age	NOUN
cajgh-4	10	30	80	80	NUM
cajgh-4	10	31	.	.	PUNCT
cajgh-4	11	1	ad	ad	NOUN
cajgh-4	11	2	is	be	AUX
cajgh-4	11	3	characterized	characterize	VERB
cajgh-4	11	4	by	by	ADP
cajgh-4	11	5	the	the	DET
cajgh-4	11	6	accumulation	accumulation	NOUN
cajgh-4	11	7	of	of	ADP
cajgh-4	11	8	amyloid	amyloid	NOUN
cajgh-4	11	9	plaques	plaque	NOUN
cajgh-4	11	10	and	and	CCONJ
cajgh-4	11	11	neurofibrillary	neurofibrillary	ADJ
cajgh-4	11	12	tangles	tangle	NOUN
cajgh-4	11	13	accompanied	accompany	VERB
cajgh-4	11	14	by	by	ADP
cajgh-4	11	15	impairment	impairment	NOUN
cajgh-4	11	16	of	of	ADP
cajgh-4	11	17	the	the	DET
cajgh-4	11	18	neurons	neuron	NOUN
cajgh-4	11	19	in	in	ADP
cajgh-4	11	20	specific	specific	ADJ
cajgh-4	11	21	regions	region	NOUN
cajgh-4	11	22	of	of	ADP
cajgh-4	11	23	the	the	DET
cajgh-4	11	24	brain	brain	NOUN
cajgh-4	11	25	.	.	PUNCT
cajgh-4	12	1	in	in	ADP
cajgh-4	12	2	particular	particular	ADJ
cajgh-4	12	3	,	,	PUNCT
cajgh-4	12	4	large	large	ADJ
cajgh-4	12	5	neurons	neuron	NOUN
cajgh-4	12	6	in	in	ADP
cajgh-4	12	7	the	the	DET
cajgh-4	12	8	neurocortex	neurocortex	NOUN
cajgh-4	12	9	,	,	PUNCT
cajgh-4	12	10	the	the	DET
cajgh-4	12	11	entorhinal	entorhinal	ADJ
cajgh-4	12	12	area	area	NOUN
cajgh-4	12	13	,	,	PUNCT
cajgh-4	12	14	hippocampus	hippocampus	NOUN
cajgh-4	12	15	,	,	PUNCT
cajgh-4	12	16	amygdale	amygdale	NOUN
cajgh-4	12	17	,	,	PUNCT
cajgh-4	12	18	nucleus	nucleus	ADJ
cajgh-4	12	19	basalis	basali	NOUN
cajgh-4	12	20	,	,	PUNCT
cajgh-4	12	21	anterior	anterior	ADJ
cajgh-4	12	22	thalamus	thalamus	NOUN
cajgh-4	12	23	,	,	PUNCT
cajgh-4	12	24	and	and	CCONJ
cajgh-4	12	25	several	several	ADJ
cajgh-4	12	26	brain	brain	NOUN
cajgh-4	12	27	stem	stem	NOUN
cajgh-4	12	28	monoaminergic	monoaminergic	ADJ
cajgh-4	12	29	nuclei	nucleus	NOUN
cajgh-4	12	30	are	be	AUX
cajgh-4	12	31	affected	affect	VERB
cajgh-4	12	32	.	.	PUNCT
cajgh-4	13	1	in	in	ADP
cajgh-4	13	2	damaged	damaged	ADJ
cajgh-4	13	3	regions	region	NOUN
cajgh-4	13	4	,	,	PUNCT
cajgh-4	13	5	the	the	DET
cajgh-4	13	6	neurons	neuron	NOUN
cajgh-4	13	7	exhibit	exhibit	VERB
cajgh-4	13	8	multiple	multiple	ADJ
cajgh-4	13	9	abnormalities	abnormality	NOUN
cajgh-4	13	10	of	of	ADP
cajgh-4	13	11	cell	cell	NOUN
cajgh-4	13	12	structure	structure	NOUN
cajgh-4	13	13	and	and	CCONJ
cajgh-4	13	14	function	function	NOUN
cajgh-4	13	15	,	,	PUNCT
cajgh-4	13	16	reduction	reduction	NOUN
cajgh-4	13	17	in	in	ADP
cajgh-4	13	18	the	the	DET
cajgh-4	13	19	level	level	NOUN
cajgh-4	13	20	of	of	ADP
cajgh-4	13	21	synaptic	synaptic	ADJ
cajgh-4	13	22	proteins	protein	NOUN
cajgh-4	13	23	,	,	PUNCT
cajgh-4	13	24	and	and	CCONJ
cajgh-4	13	25	,	,	PUNCT
cajgh-4	13	26	finally	finally	ADV
cajgh-4	13	27	,	,	PUNCT
cajgh-4	13	28	they	they	PRON
cajgh-4	13	29	die.1	die.1	VERB
cajgh-4	13	30	the	the	DET
cajgh-4	13	31	neuronal	neuronal	ADJ
cajgh-4	13	32	loss	loss	NOUN
cajgh-4	13	33	in	in	ADP
cajgh-4	13	34	ad	ad	NOUN
cajgh-4	13	35	brains	brain	NOUN
cajgh-4	13	36	is	be	AUX
cajgh-4	13	37	accompanied	accompany	VERB
cajgh-4	13	38	by	by	ADP
cajgh-4	13	39	progressive	progressive	ADJ
cajgh-4	13	40	deterioration	deterioration	NOUN
cajgh-4	13	41	of	of	ADP
cajgh-4	13	42	cognition	cognition	NOUN
cajgh-4	13	43	and	and	CCONJ
cajgh-4	13	44	memory	memory	NOUN
cajgh-4	13	45	of	of	ADP
cajgh-4	13	46	affected	affected	ADJ
cajgh-4	13	47	individuals	individual	NOUN
cajgh-4	13	48	.	.	PUNCT
cajgh-4	14	1	although	although	SCONJ
cajgh-4	14	2	the	the	DET
cajgh-4	14	3	cause	cause	NOUN
cajgh-4	14	4	and	and	CCONJ
cajgh-4	14	5	progression	progression	NOUN
cajgh-4	14	6	of	of	ADP
cajgh-4	14	7	ad	ad	NOUN
cajgh-4	14	8	are	be	AUX
cajgh-4	14	9	still	still	ADV
cajgh-4	14	10	not	not	PART
cajgh-4	14	11	well	well	ADV
cajgh-4	14	12	understood	understand	VERB
cajgh-4	14	13	,	,	PUNCT
cajgh-4	14	14	the	the	DET
cajgh-4	14	15	amyloid	amyloid	NOUN
cajgh-4	14	16	hypothesis	hypothesis	NOUN
cajgh-4	14	17	is	be	AUX
cajgh-4	14	18	dominant	dominant	ADJ
cajgh-4	14	19	and	and	CCONJ
cajgh-4	14	20	widely	widely	ADV
cajgh-4	14	21	accepted.2	accepted.2	VERB
cajgh-4	14	22	according	accord	VERB
cajgh-4	14	23	to	to	ADP
cajgh-4	14	24	this	this	DET
cajgh-4	14	25	hypothesis	hypothesis	NOUN
cajgh-4	14	26	,	,	PUNCT
cajgh-4	14	27	an	an	DET
cajgh-4	14	28	increased	increase	VERB
cajgh-4	14	29	deposition	deposition	NOUN
cajgh-4	14	30	of	of	ADP
cajgh-4	14	31	amyloid	amyloid	NOUN
cajgh-4	14	32	-	-	PUNCT
cajgh-4	14	33	β	β	NOUN
cajgh-4	14	34	peptide	peptide	NOUN
cajgh-4	14	35	,	,	PUNCT
cajgh-4	14	36	the	the	DET
cajgh-4	14	37	main	main	ADJ
cajgh-4	14	38	constituent	constituent	NOUN
cajgh-4	14	39	of	of	ADP
cajgh-4	14	40	senile	senile	ADJ
cajgh-4	14	41	plagues	plague	NOUN
cajgh-4	14	42	,	,	PUNCT
cajgh-4	14	43	is	be	AUX
cajgh-4	14	44	the	the	DET
cajgh-4	14	45	main	main	ADJ
cajgh-4	14	46	cause	cause	NOUN
cajgh-4	14	47	of	of	ADP
cajgh-4	14	48	neuronal	neuronal	ADJ
cajgh-4	14	49	dysfunction	dysfunction	NOUN
cajgh-4	14	50	and	and	CCONJ
cajgh-4	14	51	death	death	NOUN
cajgh-4	14	52	in	in	ADP
cajgh-4	14	53	ad	ad	NOUN
cajgh-4	14	54	.	.	PUNCT
cajgh-4	15	1	the	the	DET
cajgh-4	15	2	rest	rest	NOUN
cajgh-4	15	3	of	of	ADP
cajgh-4	15	4	the	the	DET
cajgh-4	15	5	disease	disease	NOUN
cajgh-4	15	6	process	process	NOUN
cajgh-4	15	7	,	,	PUNCT
cajgh-4	15	8	including	include	VERB
cajgh-4	15	9	formation	formation	NOUN
cajgh-4	15	10	of	of	ADP
cajgh-4	15	11	neurofibrillary	neurofibrillary	ADJ
cajgh-4	15	12	tangles	tangle	NOUN
cajgh-4	15	13	containing	contain	VERB
cajgh-4	15	14	tau	tau	PROPN
cajgh-4	15	15	protein	protein	NOUN
cajgh-4	15	16	,	,	PUNCT
cajgh-4	15	17	is	be	AUX
cajgh-4	15	18	proposed	propose	VERB
cajgh-4	15	19	to	to	PART
cajgh-4	15	20	result	result	VERB
cajgh-4	15	21	from	from	ADP
cajgh-4	15	22	an	an	DET
cajgh-4	15	23	imbalance	imbalance	NOUN
cajgh-4	15	24	between	between	ADP
cajgh-4	15	25	aβ	aβ	NOUN
cajgh-4	15	26	production	production	NOUN
cajgh-4	15	27	and	and	CCONJ
cajgh-4	15	28	aβ	aβ	NOUN
cajgh-4	15	29	clearance	clearance	NOUN
cajgh-4	15	30	.	.	PUNCT
cajgh-4	16	1	aβ	aβ	NOUN
cajgh-4	16	2	is	be	AUX
cajgh-4	16	3	derived	derive	VERB
cajgh-4	16	4	from	from	ADP
cajgh-4	16	5	amyloidogenic	amyloidogenic	ADJ
cajgh-4	16	6	cleavage	cleavage	NOUN
cajgh-4	16	7	of	of	ADP
cajgh-4	16	8	membrane	membrane	NOUN
cajgh-4	16	9	bound	bind	VERB
cajgh-4	16	10	amyloid	amyloid	NOUN
cajgh-4	16	11	precursor	precursor	NOUN
cajgh-4	16	12	protein	protein	NOUN
cajgh-4	16	13	(	(	PUNCT
cajgh-4	16	14	app	app	PROPN
cajgh-4	16	15	)	)	PUNCT
cajgh-4	16	16	by	by	ADP
cajgh-4	16	17	band	band	NOUN
cajgh-4	16	18	g	g	NOUN
cajgh-4	16	19	-	-	PUNCT
cajgh-4	16	20	secretase.3	secretase.3	ADJ
cajgh-4	16	21	amyloidogenic	amyloidogenic	ADJ
cajgh-4	16	22	processing	processing	NOUN
cajgh-4	16	23	of	of	ADP
cajgh-4	16	24	the	the	DET
cajgh-4	16	25	app	app	NOUN
cajgh-4	16	26	leads	lead	VERB
cajgh-4	16	27	to	to	ADP
cajgh-4	16	28	the	the	DET
cajgh-4	16	29	production	production	NOUN
cajgh-4	16	30	of	of	ADP
cajgh-4	16	31	aβ	aβ	NOUN
cajgh-4	16	32	peptides	peptide	NOUN
cajgh-4	16	33	of	of	ADP
cajgh-4	16	34	different	different	ADJ
cajgh-4	16	35	length	length	NOUN
cajgh-4	16	36	,	,	PUNCT
cajgh-4	16	37	of	of	ADP
cajgh-4	16	38	which	which	PRON
cajgh-4	16	39	the	the	DET
cajgh-4	16	40	aβ1	aβ1	NOUN
cajgh-4	16	41	-	-	PUNCT
cajgh-4	16	42	40	40	NUM
cajgh-4	16	43	is	be	AUX
cajgh-4	16	44	the	the	DET
cajgh-4	16	45	major	major	ADJ
cajgh-4	16	46	species	specie	NOUN
cajgh-4	16	47	and	and	CCONJ
cajgh-4	16	48	the	the	DET
cajgh-4	16	49	aβ1	aβ1	NOUN
cajgh-4	16	50	-	-	PUNCT
cajgh-4	16	51	42	42	NUM
cajgh-4	16	52	is	be	AUX
cajgh-4	16	53	the	the	DET
cajgh-4	16	54	most	most	ADV
cajgh-4	16	55	fibrillogenic	fibrillogenic	ADJ
cajgh-4	16	56	and	and	CCONJ
cajgh-4	16	57	predominant	predominant	ADJ
cajgh-4	16	58	component	component	NOUN
cajgh-4	16	59	in	in	ADP
cajgh-4	16	60	ad	ad	NOUN
cajgh-4	16	61	plaques.4	plaques.4	PROPN
cajgh-4	16	62	there	there	PRON
cajgh-4	16	63	is	be	VERB
cajgh-4	16	64	major	major	ADJ
cajgh-4	16	65	evidence	evidence	NOUN
cajgh-4	16	66	which	which	PRON
cajgh-4	16	67	supports	support	VERB
cajgh-4	16	68	amyloid	amyloid	NOUN
cajgh-4	16	69	cascade	cascade	NOUN
cajgh-4	16	70	hypothesis	hypothesis	NOUN
cajgh-4	16	71	.	.	PUNCT
cajgh-4	17	1	the	the	DET
cajgh-4	17	2	first	first	ADJ
cajgh-4	17	3	comes	come	VERB
cajgh-4	17	4	from	from	ADP
cajgh-4	17	5	the	the	DET
cajgh-4	17	6	link	link	NOUN
cajgh-4	17	7	between	between	ADP
cajgh-4	17	8	ad	ad	NOUN
cajgh-4	17	9	and	and	CCONJ
cajgh-4	17	10	down	down	ADP
cajgh-4	17	11	’s	’s	PART
cajgh-4	17	12	syndrome	syndrome	NOUN
cajgh-4	17	13	.	.	PUNCT
cajgh-4	18	1	the	the	DET
cajgh-4	18	2	app	app	PROPN
cajgh-4	18	3	gene	gene	NOUN
cajgh-4	18	4	is	be	AUX
cajgh-4	18	5	localized	localize	VERB
cajgh-4	18	6	on	on	ADP
cajgh-4	18	7	chromosome	chromosome	NOUN
cajgh-4	18	8	21	21	NUM
cajgh-4	18	9	,	,	PUNCT
cajgh-4	18	10	and	and	CCONJ
cajgh-4	18	11	people	people	NOUN
cajgh-4	18	12	with	with	ADP
cajgh-4	18	13	down	down	ADP
cajgh-4	18	14	syndrome	syndrome	NOUN
cajgh-4	18	15	(	(	PUNCT
cajgh-4	18	16	trisomy	trisomy	NOUN
cajgh-4	18	17	21	21	NUM
cajgh-4	18	18	)	)	PUNCT
cajgh-4	18	19	who	who	PRON
cajgh-4	18	20	,	,	PUNCT
cajgh-4	18	21	thus	thus	ADV
cajgh-4	18	22	,	,	PUNCT
cajgh-4	18	23	have	have	VERB
cajgh-4	18	24	an	an	DET
cajgh-4	18	25	extra	extra	ADJ
cajgh-4	18	26	gene	gene	NOUN
cajgh-4	18	27	copy	copy	NOUN
cajgh-4	18	28	almost	almost	ADV
cajgh-4	18	29	invariably	invariably	ADV
cajgh-4	18	30	develop	develop	VERB
cajgh-4	18	31	ad	ad	NOUN
cajgh-4	18	32	-	-	PUNCT
cajgh-4	18	33	like	like	ADJ
cajgh-4	18	34	neuropathology	neuropathology	NOUN
cajgh-4	18	35	by	by	ADP
cajgh-4	18	36	the	the	DET
cajgh-4	18	37	age	age	NOUN
cajgh-4	18	38	of	of	ADP
cajgh-4	18	39	40	40	NUM
cajgh-4	18	40	.	.	PUNCT
cajgh-4	19	1	secondly	secondly	ADV
cajgh-4	19	2	,	,	PUNCT
cajgh-4	19	3	inherited	inherit	VERB
cajgh-4	19	4	mutations	mutation	NOUN
cajgh-4	19	5	in	in	ADP
cajgh-4	19	6	the	the	DET
cajgh-4	19	7	app	app	NOUN
cajgh-4	19	8	and	and	CCONJ
cajgh-4	19	9	presenilin	presenilin	PROPN
cajgh-4	19	10	genes	gene	NOUN
cajgh-4	19	11	(	(	PUNCT
cajgh-4	19	12	presenilin	presenilin	PROPN
cajgh-4	19	13	constitutes	constitute	VERB
cajgh-4	19	14	the	the	DET
cajgh-4	19	15	catalytic	catalytic	ADJ
cajgh-4	19	16	site	site	NOUN
cajgh-4	19	17	of	of	ADP
cajgh-4	19	18	the	the	DET
cajgh-4	19	19	γ	γ	NOUN
cajgh-4	19	20	-	-	PUNCT
cajgh-4	19	21	secretase	secretase	NOUN
cajgh-4	19	22	)	)	PUNCT
cajgh-4	19	23	cause	cause	VERB
cajgh-4	19	24	early	early	ADJ
cajgh-4	19	25	and	and	CCONJ
cajgh-4	19	26	aggressive	aggressive	ADJ
cajgh-4	19	27	forms	form	NOUN
cajgh-4	19	28	of	of	ADP
cajgh-4	19	29	ad	ad	NOUN
cajgh-4	19	30	.	.	PUNCT
cajgh-4	20	1	and	and	CCONJ
cajgh-4	20	2	thirdly	thirdly	ADV
cajgh-4	20	3	,	,	PUNCT
cajgh-4	20	4	transgenic	transgenic	NOUN
cajgh-4	20	5	mice	mouse	NOUN
cajgh-4	20	6	with	with	ADP
cajgh-4	20	7	mutant	mutant	ADJ
cajgh-4	20	8	form	form	NOUN
cajgh-4	20	9	of	of	ADP
cajgh-4	20	10	human	human	ADJ
cajgh-4	20	11	app	app	NOUN
cajgh-4	20	12	develop	develop	VERB
cajgh-4	20	13	amyloid	amyloid	NOUN
cajgh-4	20	14	fibrillar	fibrillar	ADJ
cajgh-4	20	15	plaques	plaque	NOUN
cajgh-4	20	16	and	and	CCONJ
cajgh-4	20	17	alzhemer	alzhemer	NOUN
cajgh-4	20	18	’s	’s	PART
cajgh-4	20	19	like	like	ADP
cajgh-4	20	20	brain	brain	NOUN
cajgh-4	20	21	pathology.2	pathology.2	PROPN
cajgh-4	20	22	recent	recent	ADJ
cajgh-4	20	23	reports	report	NOUN
cajgh-4	20	24	have	have	AUX
cajgh-4	20	25	suggested	suggest	VERB
cajgh-4	20	26	that	that	SCONJ
cajgh-4	20	27	the	the	DET
cajgh-4	20	28	soluble	soluble	ADJ
cajgh-4	20	29	oligomeric	oligomeric	ADJ
cajgh-4	20	30	form	form	NOUN
cajgh-4	20	31	of	of	ADP
cajgh-4	20	32	the	the	DET
cajgh-4	20	33	peptide	peptide	NOUN
cajgh-4	20	34	is	be	AUX
cajgh-4	20	35	the	the	DET
cajgh-4	20	36	most	most	ADV
cajgh-4	20	37	toxic	toxic	ADJ
cajgh-4	20	38	and	and	CCONJ
cajgh-4	20	39	responsible	responsible	ADJ
cajgh-4	20	40	for	for	ADP
cajgh-4	20	41	the	the	DET
cajgh-4	20	42	disruption	disruption	NOUN
cajgh-4	20	43	of	of	ADP
cajgh-4	20	44	synaptic	synaptic	ADJ
cajgh-4	20	45	plasticity	plasticity	NOUN
cajgh-4	20	46	,	,	PUNCT
cajgh-4	20	47	neuronal	neuronal	ADJ
cajgh-4	20	48	death	death	NOUN
cajgh-4	20	49	and	and	CCONJ
cajgh-4	20	50	decline	decline	NOUN
cajgh-4	20	51	of	of	ADP
cajgh-4	20	52	cognitive	cognitive	ADJ
cajgh-4	20	53	function.5,6	function.5,6	NOUN
cajgh-4	20	54	although	although	SCONJ
cajgh-4	20	55	precise	precise	ADJ
cajgh-4	20	56	mechanism	mechanism	NOUN
cajgh-4	20	57	of	of	ADP
cajgh-4	20	58	aβ	aβ	PRON
cajgh-4	20	59	oligomers	oligomer	NOUN
cajgh-4	20	60	neurotoxic	neurotoxic	ADJ
cajgh-4	20	61	effects	effect	NOUN
cajgh-4	20	62	remains	remain	VERB
cajgh-4	20	63	unclear	unclear	ADJ
cajgh-4	20	64	,	,	PUNCT
cajgh-4	20	65	in	in	ADP
cajgh-4	20	66	-	-	PUNCT
cajgh-4	20	67	vivo	vivo	NOUN
cajgh-4	20	68	and	and	CCONJ
cajgh-4	20	69	in	in	ADP
cajgh-4	20	70	-	-	PUNCT
cajgh-4	20	71	vitro	vitro	X
cajgh-4	20	72	studies	study	NOUN
cajgh-4	20	73	have	have	AUX
cajgh-4	20	74	demonstrated	demonstrate	VERB
cajgh-4	20	75	that	that	SCONJ
cajgh-4	20	76	aβ	aβ	PRON
cajgh-4	20	77	oligomers	oligomer	NOUN
cajgh-4	20	78	:	:	PUNCT
cajgh-4	20	79	a	a	X
cajgh-4	20	80	)	)	PUNCT
cajgh-4	20	81	induce	induce	VERB
cajgh-4	20	82	apoptosis	apoptosis	NOUN
cajgh-4	20	83	;	;	PUNCT
cajgh-4	20	84	b	b	X
cajgh-4	20	85	)	)	PUNCT
cajgh-4	20	86	initiate	initiate	VERB
cajgh-4	20	87	oxidative	oxidative	ADJ
cajgh-4	20	88	stress	stress	NOUN
cajgh-4	20	89	and	and	CCONJ
cajgh-4	20	90	free	free	ADJ
cajgh-4	20	91	-	-	PUNCT
cajgh-4	20	92	radical	radical	ADJ
cajgh-4	20	93	degeneration	degeneration	NOUN
cajgh-4	20	94	in	in	ADP
cajgh-4	20	95	neuronal	neuronal	ADJ
cajgh-4	20	96	cells	cell	NOUN
cajgh-4	20	97	;	;	PUNCT
cajgh-4	20	98	c	c	X
cajgh-4	20	99	)	)	PUNCT
cajgh-4	20	100	disrupt	disrupt	VERB
cajgh-4	20	101	calcium	calcium	NOUN
cajgh-4	20	102	homeostasis	homeostasis	NOUN
cajgh-4	20	103	and	and	CCONJ
cajgh-4	20	104	long	long	ADJ
cajgh-4	20	105	-	-	PUNCT
cajgh-4	20	106	term	term	NOUN
cajgh-4	20	107	potentiation	potentiation	NOUN
cajgh-4	20	108	;	;	PUNCT
cajgh-4	20	109	d	d	X
cajgh-4	20	110	)	)	PUNCT
cajgh-4	20	111	cause	cause	VERB
cajgh-4	20	112	neurodegeneration	neurodegeneration	NOUN
cajgh-4	20	113	by	by	ADP
cajgh-4	20	114	forming	form	VERB
cajgh-4	20	115	large	large	ADJ
cajgh-4	20	116	,	,	PUNCT
cajgh-4	20	117	voltage	voltage	NOUN
cajgh-4	20	118	independent	independent	ADJ
cajgh-4	20	119	,	,	PUNCT
cajgh-4	20	120	and	and	CCONJ
cajgh-4	20	121	nonselective	nonselective	ADJ
cajgh-4	20	122	ion	ion	NOUN
cajgh-4	20	123	channels.7,8	channels.7,8	NOUN
cajgh-4	20	124	however	however	ADV
cajgh-4	20	125	,	,	PUNCT
cajgh-4	20	126	for	for	ADP
cajgh-4	20	127	the	the	DET
cajgh-4	20	128	most	most	ADJ
cajgh-4	20	129	cases	case	NOUN
cajgh-4	20	130	of	of	ADP
cajgh-4	20	131	late	late	ADJ
cajgh-4	20	132	-	-	PUNCT
cajgh-4	20	133	onset	onset	NOUN
cajgh-4	20	134	sporadic	sporadic	ADJ
cajgh-4	20	135	non	non	ADJ
cajgh-4	20	136	-	-	ADJ
cajgh-4	20	137	inherited	inherited	ADJ
cajgh-4	20	138	ad	ad	NOUN
cajgh-4	20	139	(	(	PUNCT
cajgh-4	20	140	~95	~95	X
cajgh-4	20	141	%	%	NOUN
cajgh-4	20	142	)	)	PUNCT
cajgh-4	20	143	,	,	PUNCT
cajgh-4	20	144	the	the	DET
cajgh-4	20	145	reasons	reason	NOUN
cajgh-4	20	146	of	of	ADP
cajgh-4	20	147	increased	increase	VERB
cajgh-4	20	148	aβ	aβ	NOUN
cajgh-4	20	149	accumulation	accumulation	NOUN
cajgh-4	20	150	in	in	ADP
cajgh-4	20	151	brains	brain	NOUN
cajgh-4	20	152	remain	remain	VERB
cajgh-4	20	153	unknown	unknown	ADJ
cajgh-4	20	154	.	.	PUNCT
cajgh-4	21	1	in	in	ADP
cajgh-4	21	2	this	this	DET
cajgh-4	21	3	regard	regard	NOUN
cajgh-4	21	4	,	,	PUNCT
cajgh-4	21	5	current	current	ADJ
cajgh-4	21	6	theories	theory	NOUN
cajgh-4	21	7	imply	imply	VERB
cajgh-4	21	8	that	that	SCONJ
cajgh-4	21	9	ad	ad	NOUN
cajgh-4	21	10	is	be	AUX
cajgh-4	21	11	mainly	mainly	ADV
cajgh-4	21	12	caused	cause	VERB
cajgh-4	21	13	by	by	ADP
cajgh-4	21	14	vascular	vascular	ADJ
cajgh-4	21	15	risk	risk	NOUN
cajgh-4	21	16	factors	factor	NOUN
cajgh-4	21	17	,	,	PUNCT
cajgh-4	21	18	and	and	CCONJ
cajgh-4	21	19	that	that	DET
cajgh-4	21	20	vascular	vascular	ADJ
cajgh-4	21	21	derived	derive	VERB
cajgh-4	21	22	pathology	pathology	NOUN
cajgh-4	21	23	is	be	AUX
cajgh-4	21	24	responsible	responsible	ADJ
cajgh-4	21	25	for	for	ADP
cajgh-4	21	26	initiation	initiation	NOUN
cajgh-4	21	27	and/or	and/or	CCONJ
cajgh-4	21	28	progression	progression	NOUN
cajgh-4	21	29	of	of	ADP
cajgh-4	21	30	ad.9,11	ad.9,11	NOUN
cajgh-4	21	31	recent	recent	ADJ
cajgh-4	21	32	studies	study	NOUN
cajgh-4	21	33	provided	provide	VERB
cajgh-4	21	34	significant	significant	ADJ
cajgh-4	21	35	data	datum	NOUN
cajgh-4	21	36	supporting	support	VERB
cajgh-4	21	37	the	the	DET
cajgh-4	21	38	notion	notion	NOUN
cajgh-4	21	39	that	that	SCONJ
cajgh-4	21	40	the	the	DET
cajgh-4	21	41	pathophysiology	pathophysiology	NOUN
cajgh-4	21	42	of	of	ADP
cajgh-4	21	43	blood	blood	NOUN
cajgh-4	21	44	brain	brain	NOUN
cajgh-4	21	45	barrier	barrier	NOUN
cajgh-4	21	46	(	(	PUNCT
cajgh-4	21	47	bbb	bbb	NOUN
cajgh-4	21	48	)	)	PUNCT
cajgh-4	21	49	and	and	CCONJ
cajgh-4	21	50	imbalanced	imbalanced	ADJ
cajgh-4	21	51	interaction	interaction	NOUN
cajgh-4	21	52	between	between	ADP
cajgh-4	21	53	cerebral	cerebral	ADJ
cajgh-4	21	54	endothelial	endothelial	ADJ
cajgh-4	21	55	cells	cell	NOUN
cajgh-4	21	56	(	(	PUNCT
cajgh-4	21	57	cecs	cecs	PROPN
cajgh-4	21	58	)	)	PUNCT
cajgh-4	21	59	,	,	PUNCT
cajgh-4	21	60	glial	glial	ADJ
cajgh-4	21	61	cells	cell	NOUN
cajgh-4	21	62	and	and	CCONJ
cajgh-4	21	63	neurons	neuron	NOUN
cajgh-4	21	64	may	may	AUX
cajgh-4	21	65	trigger	trigger	VERB
cajgh-4	21	66	the	the	DET
cajgh-4	21	67	progressive	progressive	ADJ
cajgh-4	21	68	destruction	destruction	NOUN
cajgh-4	21	69	of	of	ADP
cajgh-4	21	70	cortical	cortical	ADJ
cajgh-4	21	71	neurons	neuron	NOUN
cajgh-4	21	72	in	in	ADP
cajgh-4	21	73	ad.10,12	ad.10,12	PROPN
cajgh-4	21	74	-	-	PUNCT
cajgh-4	21	75	21	21	NUM
cajgh-4	21	76	1	1	NUM
cajgh-4	21	77	.	.	PUNCT
cajgh-4	21	78	blood	blood	NOUN
cajgh-4	21	79	-	-	PUNCT
cajgh-4	21	80	brain	brain	NOUN
cajgh-4	21	81	barrier	barrier	NOUN
cajgh-4	21	82	disorder	disorder	NOUN
cajgh-4	21	83	in	in	ADP
cajgh-4	21	84	ad	ad	NOUN
cajgh-4	21	85	the	the	DET
cajgh-4	21	86	homeostasis	homeostasis	NOUN
cajgh-4	21	87	of	of	ADP
cajgh-4	21	88	the	the	DET
cajgh-4	21	89	central	central	ADJ
cajgh-4	21	90	nervous	nervous	ADJ
cajgh-4	21	91	system	system	NOUN
cajgh-4	21	92	(	(	PUNCT
cajgh-4	21	93	cns	cns	NOUN
cajgh-4	21	94	)	)	PUNCT
cajgh-4	21	95	is	be	AUX
cajgh-4	21	96	maintained	maintain	VERB
cajgh-4	21	97	by	by	ADP
cajgh-4	21	98	the	the	DET
cajgh-4	21	99	bbb	bbb	PROPN
cajgh-4	21	100	,	,	PUNCT
cajgh-4	21	101	which	which	PRON
cajgh-4	21	102	separates	separate	VERB
cajgh-4	21	103	the	the	DET
cajgh-4	21	104	brain	brain	NOUN
cajgh-4	21	105	from	from	ADP
cajgh-4	21	106	the	the	DET
cajgh-4	21	107	circulating	circulate	VERB
cajgh-4	21	108	bloodstream	bloodstream	NOUN
cajgh-4	21	109	.	.	PUNCT
cajgh-4	22	1	the	the	DET
cajgh-4	22	2	bbb	bbb	PROPN
cajgh-4	22	3	is	be	AUX
cajgh-4	22	4	formed	form	VERB
cajgh-4	22	5	by	by	ADP
cajgh-4	22	6	a	a	DET
cajgh-4	22	7	complex	complex	ADJ
cajgh-4	22	8	cellular	cellular	ADJ
cajgh-4	22	9	system	system	NOUN
cajgh-4	22	10	consisting	consist	VERB
cajgh-4	22	11	of	of	ADP
cajgh-4	22	12	cecs	cec	NOUN
cajgh-4	22	13	,	,	PUNCT
cajgh-4	22	14	astrocytes	astrocyte	NOUN
cajgh-4	22	15	,	,	PUNCT
cajgh-4	22	16	pericytes	pericyte	NOUN
cajgh-4	22	17	,	,	PUNCT
cajgh-4	22	18	perivascular	perivascular	ADJ
cajgh-4	22	19	macrophages	macrophage	NOUN
cajgh-4	22	20	,	,	PUNCT
cajgh-4	22	21	and	and	CCONJ
cajgh-4	22	22	a	a	DET
cajgh-4	22	23	basement	basement	NOUN
cajgh-4	22	24	membrane	membrane	NOUN
cajgh-4	22	25	(	(	PUNCT
cajgh-4	22	26	fig	fig	NOUN
cajgh-4	22	27	1.).22	1.).22	NUM
cajgh-4	22	28	figure	figure	NOUN
cajgh-4	22	29	1	1	NUM
cajgh-4	22	30	.	.	PUNCT
cajgh-4	23	1	the	the	DET
cajgh-4	23	2	blood	blood	NOUN
cajgh-4	23	3	-	-	PUNCT
cajgh-4	23	4	brain	brain	NOUN
cajgh-4	23	5	barrier	barrier	NOUN
cajgh-4	23	6	.	.	PUNCT
cajgh-4	24	1	cecs	cec	NOUN
cajgh-4	24	2	layer	layer	NOUN
cajgh-4	24	3	is	be	AUX
cajgh-4	24	4	a	a	DET
cajgh-4	24	5	major	major	ADJ
cajgh-4	24	6	component	component	NOUN
cajgh-4	24	7	of	of	ADP
cajgh-4	24	8	the	the	DET
cajgh-4	24	9	bbb	bbb	NOUN
cajgh-4	24	10	which	which	PRON
cajgh-4	24	11	is	be	AUX
cajgh-4	24	12	comprised	comprise	VERB
cajgh-4	24	13	of	of	ADP
cajgh-4	24	14	high	high	ADJ
cajgh-4	24	15	-	-	PUNCT
cajgh-4	24	16	density	density	NOUN
cajgh-4	24	17	cells	cell	NOUN
cajgh-4	24	18	connected	connect	VERB
cajgh-4	24	19	by	by	ADP
cajgh-4	24	20	tight	tight	ADJ
cajgh-4	24	21	junctions	junction	NOUN
cajgh-4	24	22	.	.	PUNCT
cajgh-4	25	1	cecs	cec	NOUN
cajgh-4	25	2	have	have	VERB
cajgh-4	25	3	a	a	DET
cajgh-4	25	4	little	little	ADJ
cajgh-4	25	5	number	number	NOUN
cajgh-4	25	6	of	of	ADP
cajgh-4	25	7	endothelial	endothelial	ADJ
cajgh-4	25	8	pores	pore	NOUN
cajgh-4	25	9	,	,	PUNCT
cajgh-4	25	10	rich	rich	ADJ
cajgh-4	25	11	in	in	ADP
cajgh-4	25	12	mitochondria	mitochondria	NOUN
cajgh-4	25	13	,	,	PUNCT
cajgh-4	25	14	and	and	CCONJ
cajgh-4	25	15	have	have	VERB
cajgh-4	25	16	a	a	DET
cajgh-4	25	17	very	very	ADV
cajgh-4	25	18	low	low	ADJ
cajgh-4	25	19	content	content	NOUN
cajgh-4	25	20	of	of	ADP
cajgh-4	25	21	the	the	DET
cajgh-4	25	22	pinocytic	pinocytic	ADJ
cajgh-4	25	23	vesicles	vesicle	NOUN
cajgh-4	25	24	.	.	PUNCT
cajgh-4	26	1	the	the	DET
cajgh-4	26	2	biomechanical	biomechanical	ADJ
cajgh-4	26	3	properties	property	NOUN
cajgh-4	26	4	of	of	ADP
cajgh-4	26	5	the	the	DET
cajgh-4	26	6	cecs	cec	NOUN
cajgh-4	26	7	are	be	AUX
cajgh-4	26	8	critical	critical	ADJ
cajgh-4	26	9	to	to	ADP
cajgh-4	26	10	the	the	DET
cajgh-4	26	11	regulation	regulation	NOUN
cajgh-4	26	12	of	of	ADP
cajgh-4	26	13	many	many	ADJ
cajgh-4	26	14	cellular	cellular	ADJ
cajgh-4	26	15	functions	function	NOUN
cajgh-4	26	16	,	,	PUNCT
cajgh-4	26	17	such	such	ADJ
cajgh-4	26	18	as	as	ADP
cajgh-4	26	19	adhesion	adhesion	NOUN
cajgh-4	26	20	,	,	PUNCT
cajgh-4	26	21	signaling	signaling	NOUN
cajgh-4	26	22	and	and	CCONJ
cajgh-4	26	23	morphology	morphology	NOUN
cajgh-4	26	24	,	,	PUNCT
cajgh-4	26	25	and	and	CCONJ
cajgh-4	26	26	play	play	VERB
cajgh-4	26	27	a	a	DET
cajgh-4	26	28	vital	vital	ADJ
cajgh-4	26	29	role	role	NOUN
cajgh-4	26	30	for	for	ADP
cajgh-4	26	31	the	the	DET
cajgh-4	26	32	maintenance	maintenance	NOUN
cajgh-4	26	33	of	of	ADP
cajgh-4	26	34	the	the	DET
cajgh-4	26	35	bbb	bbb	NOUN
cajgh-4	26	36	permeability	permeability	NOUN
cajgh-4	26	37	,	,	PUNCT
cajgh-4	26	38	and	and	CCONJ
cajgh-4	26	39	brain	brain	NOUN
cajgh-4	26	40	parenchyma	parenchyma	NOUN
cajgh-4	26	41	homeostasis	homeostasis	NOUN
cajgh-4	26	42	.	.	PUNCT
cajgh-4	27	1	astrocytes	astrocyte	NOUN
cajgh-4	27	2	,	,	PUNCT
cajgh-4	27	3	the	the	DET
cajgh-4	27	4	most	most	ADV
cajgh-4	27	5	frequent	frequent	ADJ
cajgh-4	27	6	cells	cell	NOUN
cajgh-4	27	7	of	of	ADP
cajgh-4	27	8	the	the	DET
cajgh-4	27	9	brain	brain	NOUN
cajgh-4	27	10	,	,	PUNCT
cajgh-4	27	11	also	also	ADV
cajgh-4	27	12	play	play	VERB
cajgh-4	27	13	an	an	DET
cajgh-4	27	14	important	important	ADJ
cajgh-4	27	15	role	role	NOUN
cajgh-4	27	16	in	in	ADP
cajgh-4	27	17	maintaining	maintain	VERB
cajgh-4	27	18	bbb	bbb	PROPN
cajgh-4	27	19	function	function	NOUN
cajgh-4	27	20	.	.	PUNCT
cajgh-4	28	1	their	their	PRON
cajgh-4	28	2	end	end	NOUN
cajgh-4	28	3	feet	foot	NOUN
cajgh-4	28	4	tightly	tightly	ADV
cajgh-4	28	5	connected	connect	VERB
cajgh-4	28	6	to	to	ADP
cajgh-4	28	7	the	the	DET
cajgh-4	28	8	cecs	cec	NOUN
cajgh-4	28	9	influencing	influence	VERB
cajgh-4	28	10	cerebrovascular	cerebrovascular	ADJ
cajgh-4	28	11	tone	tone	NOUN
cajgh-4	28	12	and	and	CCONJ
cajgh-4	28	13	the	the	DET
cajgh-4	28	14	barrier	barrier	NOUN
cajgh-4	28	15	properties	property	NOUN
cajgh-4	28	16	of	of	ADP
cajgh-4	28	17	endothelium.20	endothelium.20	NOUN
cajgh-4	28	18	pericytes	pericyte	NOUN
cajgh-4	28	19	are	be	AUX
cajgh-4	28	20	characterized	characterize	VERB
cajgh-4	28	21	as	as	ADP
cajgh-4	28	22	contractile	contractile	NOUN
cajgh-4	28	23	cells	cell	NOUN
cajgh-4	28	24	that	that	PRON
cajgh-4	28	25	surround	surround	VERB
cajgh-4	28	26	the	the	DET
cajgh-4	28	27	brain	brain	NOUN
cajgh-4	28	28	capillaries	capillary	NOUN
cajgh-4	28	29	.	.	PUNCT
cajgh-4	29	1	pericytes	pericyte	NOUN
cajgh-4	29	2	play	play	VERB
cajgh-4	29	3	an	an	DET
cajgh-4	29	4	important	important	ADJ
cajgh-4	29	5	role	role	NOUN
cajgh-4	29	6	in	in	ADP
cajgh-4	29	7	maintaining	maintain	VERB
cajgh-4	29	8	the	the	DET
cajgh-4	29	9	stability	stability	NOUN
cajgh-4	29	10	of	of	ADP
cajgh-4	29	11	microvessels	microvessel	NOUN
cajgh-4	29	12	and	and	CCONJ
cajgh-4	29	13	modulation	modulation	NOUN
cajgh-4	29	14	of	of	ADP
cajgh-4	29	15	cerebral	cerebral	ADJ
cajgh-4	29	16	blood	blood	NOUN
cajgh-4	29	17	flow	flow	NOUN
cajgh-4	29	18	(	(	PUNCT
cajgh-4	29	19	cbf	cbf	PROPN
cajgh-4	29	20	)	)	PUNCT
cajgh-4	29	21	.	.	PUNCT
cajgh-4	30	1	sporadic	sporadic	ADJ
cajgh-4	30	2	microglia	microglia	NOUN
cajgh-4	30	3	can	can	AUX
cajgh-4	30	4	also	also	ADV
cajgh-4	30	5	be	be	AUX
cajgh-4	30	6	found	find	VERB
cajgh-4	30	7	in	in	ADP
cajgh-4	30	8	the	the	DET
cajgh-4	30	9	surrounding	surround	VERB
cajgh-4	30	10	pericapillary	pericapillary	ADJ
cajgh-4	30	11	area	area	NOUN
cajgh-4	30	12	in	in	ADP
cajgh-4	30	13	normal	normal	ADJ
cajgh-4	30	14	brain.16	brain.16	NOUN
cajgh-4	30	15	there	there	PRON
cajgh-4	30	16	is	be	VERB
cajgh-4	30	17	increasing	increase	VERB
cajgh-4	30	18	body	body	NOUN
cajgh-4	30	19	of	of	ADP
cajgh-4	30	20	evidence	evidence	NOUN
cajgh-4	30	21	that	that	SCONJ
cajgh-4	30	22	bbb	bbb	PROPN
cajgh-4	30	23	dysfunction	dysfunction	NOUN
cajgh-4	30	24	plays	play	VERB
cajgh-4	30	25	an	an	DET
cajgh-4	30	26	important	important	ADJ
cajgh-4	30	27	role	role	NOUN
cajgh-4	30	28	in	in	ADP
cajgh-4	30	29	the	the	DET
cajgh-4	30	30	development	development	NOUN
cajgh-4	30	31	and	and	CCONJ
cajgh-4	30	32	progression	progression	NOUN
cajgh-4	30	33	of	of	ADP
cajgh-4	30	34	ad.14	ad.14	PROPN
cajgh-4	30	35	-	-	PUNCT
cajgh-4	30	36	17,23,24	17,23,24	VERB
cajgh-4	30	37	vascular	vascular	ADJ
cajgh-4	30	38	disorders	disorder	NOUN
cajgh-4	30	39	like	like	ADP
cajgh-4	30	40	atherosclerosis	atherosclerosis	NOUN
cajgh-4	30	41	,	,	PUNCT
cajgh-4	30	42	ischemia	ischemia	NOUN
cajgh-4	30	43	,	,	PUNCT
cajgh-4	30	44	hypertension	hypertension	NOUN
cajgh-4	30	45	,	,	PUNCT
cajgh-4	30	46	and	and	CCONJ
cajgh-4	30	47	stroke	stroke	NOUN
cajgh-4	30	48	are	be	AUX
cajgh-4	30	49	among	among	ADP
cajgh-4	30	50	the	the	DET
cajgh-4	30	51	risk	risk	NOUN
cajgh-4	30	52	factors	factor	NOUN
cajgh-4	30	53	for	for	ADP
cajgh-4	30	54	ad.18,20,21	ad.18,20,21	NOUN
cajgh-4	30	55	in	in	ADP
cajgh-4	30	56	the	the	DET
cajgh-4	30	57	early	early	ADJ
cajgh-4	30	58	stage	stage	NOUN
cajgh-4	30	59	of	of	ADP
cajgh-4	30	60	ad	ad	NOUN
cajgh-4	30	61	,	,	PUNCT
cajgh-4	30	62	microvasculature	microvasculature	NOUN
cajgh-4	30	63	deficiencies	deficiency	NOUN
cajgh-4	30	64	,	,	PUNCT
cajgh-4	30	65	inflammatory	inflammatory	ADJ
cajgh-4	30	66	reactions	reaction	NOUN
cajgh-4	30	67	,	,	PUNCT
cajgh-4	30	68	surrounding	surround	VERB
cajgh-4	30	69	the	the	DET
cajgh-4	30	70	cerebral	cerebral	ADJ
cajgh-4	30	71	vasculature	vasculature	NOUN
cajgh-4	30	72	and	and	CCONJ
cajgh-4	30	73	endothelial	endothelial	ADJ
cajgh-4	30	74	dysfunctions	dysfunction	NOUN
cajgh-4	30	75	are	be	AUX
cajgh-4	30	76	commonly	commonly	ADV
cajgh-4	30	77	observed.25	observed.25	ADJ
cajgh-4	30	78	the	the	DET
cajgh-4	30	79	increased	increase	VERB
cajgh-4	30	80	number	number	NOUN
cajgh-4	30	81	of	of	ADP
cajgh-4	30	82	perivascular	perivascular	ADJ
cajgh-4	30	83	macrophages	macrophage	NOUN
cajgh-4	30	84	and	and	CCONJ
cajgh-4	30	85	hypertrophy	hypertrophy	NOUN
cajgh-4	30	86	of	of	ADP
cajgh-4	30	87	astrocytes	astrocyte	NOUN
cajgh-4	30	88	and	and	CCONJ
cajgh-4	30	89	microglia	microglia	NOUN
cajgh-4	30	90	is	be	AUX
cajgh-4	30	91	commonly	commonly	ADV
cajgh-4	30	92	observed	observe	VERB
cajgh-4	30	93	in	in	ADP
cajgh-4	30	94	ad	ad	NOUN
cajgh-4	30	95	brain	brain	NOUN
cajgh-4	30	96	sections.26	sections.26	NOUN
cajgh-4	30	97	numerous	numerous	ADJ
cajgh-4	30	98	observations	observation	NOUN
cajgh-4	30	99	have	have	AUX
cajgh-4	30	100	indicated	indicate	VERB
cajgh-4	30	101	decreased	decrease	VERB
cajgh-4	30	102	cerebral	cerebral	ADJ
cajgh-4	30	103	blood	blood	NOUN
cajgh-4	30	104	flow	flow	NOUN
cajgh-4	30	105	,	,	PUNCT
cajgh-4	30	106	reduced	reduce	VERB
cajgh-4	30	107	total	total	ADJ
cajgh-4	30	108	microvascular	microvascular	NOUN
cajgh-4	30	109	density	density	NOUN
cajgh-4	30	110	,	,	PUNCT
cajgh-4	30	111	and	and	CCONJ
cajgh-4	30	112	low	low	ADJ
cajgh-4	30	113	immunoreactivity	immunoreactivity	NOUN
cajgh-4	30	114	of	of	ADP
cajgh-4	30	115	endothelial	endothelial	ADJ
cajgh-4	30	116	markers	marker	NOUN
cajgh-4	30	117	cd34	cd34	PROPN
cajgh-4	30	118	and	and	CCONJ
cajgh-4	30	119	cd3	cd3	VERB
cajgh-4	30	120	in	in	ADP
cajgh-4	30	121	ad	ad	NOUN
cajgh-4	30	122	brains.27	brains.27	PROPN
cajgh-4	30	123	-	-	ADJ
cajgh-4	30	124	32	32	NUM
cajgh-4	30	125	light	light	NOUN
cajgh-4	30	126	and	and	CCONJ
cajgh-4	30	127	electron	electron	NOUN
cajgh-4	30	128	microscopy	microscopy	NOUN
cajgh-4	30	129	studies	study	NOUN
cajgh-4	30	130	have	have	AUX
cajgh-4	30	131	demonstrated	demonstrate	VERB
cajgh-4	30	132	decreased	decrease	VERB
cajgh-4	30	133	mitochondrial	mitochondrial	ADJ
cajgh-4	30	134	and	and	CCONJ
cajgh-4	30	135	increased	increase	VERB
cajgh-4	30	136	pinocytotic	pinocytotic	ADJ
cajgh-4	30	137	vesicles	vesicle	NOUN
cajgh-4	30	138	content	content	NOUN
cajgh-4	30	139	,	,	PUNCT
cajgh-4	30	140	swelling	swelling	NOUN
cajgh-4	30	141	and	and	CCONJ
cajgh-4	30	142	degeneration	degeneration	NOUN
cajgh-4	30	143	of	of	ADP
cajgh-4	30	144	endothelial	endothelial	ADJ
cajgh-4	30	145	cells.33,34	cells.33,34	NOUN
cajgh-4	30	146	in	in	ADP
cajgh-4	30	147	-	-	PUNCT
cajgh-4	30	148	vitro	vitro	X
cajgh-4	30	149	,	,	PUNCT
cajgh-4	30	150	amyloid	amyloid	NOUN
cajgh-4	30	151	beta	beta	NOUN
cajgh-4	30	152	peptide	peptide	NOUN
cajgh-4	30	153	has	have	AUX
cajgh-4	30	154	been	be	AUX
cajgh-4	30	155	shown	show	VERB
cajgh-4	30	156	to	to	PART
cajgh-4	30	157	induce	induce	VERB
cajgh-4	30	158	significant	significant	ADJ
cajgh-4	30	159	dysfunctions	dysfunction	NOUN
cajgh-4	30	160	in	in	ADP
cajgh-4	30	161	the	the	DET
cajgh-4	30	162	cecs	cec	NOUN
cajgh-4	30	163	.	.	PUNCT
cajgh-4	31	1	specifically	specifically	ADV
cajgh-4	31	2	,	,	PUNCT
cajgh-4	31	3	aβ	aβ	PRON
cajgh-4	31	4	suppressed	suppress	VERB
cajgh-4	31	5	cecs	cec	NOUN
cajgh-4	31	6	proliferation	proliferation	NOUN
cajgh-4	31	7	and	and	CCONJ
cajgh-4	31	8	migration	migration	NOUN
cajgh-4	31	9	,	,	PUNCT
cajgh-4	31	10	affected	affect	VERB
cajgh-4	31	11	tube	tube	NOUN
cajgh-4	31	12	formation	formation	NOUN
cajgh-4	31	13	in	in	ADP
cajgh-4	31	14	the	the	DET
cajgh-4	31	15	human	human	ADJ
cajgh-4	31	16	brain	brain	NOUN
cajgh-4	31	17	endothelial	endothelial	NOUN
cajgh-4	31	18	cells	cell	NOUN
cajgh-4	31	19	(	(	PUNCT
cajgh-4	31	20	hbec	hbec	PROPN
cajgh-4	31	21	)	)	PUNCT
cajgh-4	31	22	,	,	PUNCT
cajgh-4	31	23	induced	induce	VERB
cajgh-4	31	24	endothelial	endothelial	NOUN
cajgh-4	31	25	autophagy	autophagy	NOUN
cajgh-4	31	26	through	through	ADP
cajgh-4	31	27	the	the	DET
cajgh-4	31	28	dissociation	dissociation	NOUN
cajgh-4	31	29	of	of	ADP
cajgh-4	31	30	erk	erk	PROPN
cajgh-4	31	31	and	and	CCONJ
cajgh-4	31	32	akt	akt	PROPN
cajgh-4	31	33	signaling	signal	VERB
cajgh-4	31	34	and	and	CCONJ
cajgh-4	31	35	intracellular	intracellular	ADJ
cajgh-4	31	36	regulation	regulation	NOUN
cajgh-4	31	37	of	of	ADP
cajgh-4	31	38	class	class	NOUN
cajgh-4	31	39	3	3	NUM
cajgh-4	31	40	phosphatidylinositol	phosphatidylinositol	NOUN
cajgh-4	31	41	3	3	NUM
cajgh-4	31	42	-	-	PUNCT
cajgh-4	31	43	kinase.35,36	kinase.35,36	NOUN
cajgh-4	31	44	physiological	physiological	ADJ
cajgh-4	31	45	concentrations	concentration	NOUN
cajgh-4	31	46	of	of	ADP
cajgh-4	31	47	soluble	soluble	ADJ
cajgh-4	31	48	aβ	aβ	NOUN
cajgh-4	31	49	(	(	PUNCT
cajgh-4	31	50	10	10	NUM
cajgh-4	31	51	-	-	SYM
cajgh-4	31	52	9	9	NUM
cajgh-4	31	53	10	10	NUM
cajgh-4	31	54	-	-	SYM
cajgh-4	31	55	6	6	NUM
cajgh-4	31	56	m	m	NOUN
cajgh-4	31	57	)	)	PUNCT
cajgh-4	31	58	induced	induce	VERB
cajgh-4	31	59	dose	dose	NOUN
cajgh-4	31	60	-	-	PUNCT
cajgh-4	31	61	dependent	dependent	ADJ
cajgh-4	31	62	reduction	reduction	NOUN
cajgh-4	31	63	of	of	ADP
cajgh-4	31	64	no	no	DET
cajgh-4	31	65	production	production	NOUN
cajgh-4	31	66	,	,	PUNCT
cajgh-4	31	67	decreased	decrease	VERB
cajgh-4	31	68	sensitivity	sensitivity	NOUN
cajgh-4	31	69	of	of	ADP
cajgh-4	31	70	neurovasculature	neurovasculature	NOUN
cajgh-4	31	71	to	to	ADP
cajgh-4	31	72	an	an	DET
cajgh-4	31	73	endothelium	endothelium	NOUN
cajgh-4	31	74	dependent	dependent	ADJ
cajgh-4	31	75	vasodilator	vasodilator	NOUN
cajgh-4	31	76	acetylcholine	acetylcholine	NOUN
cajgh-4	31	77	,	,	PUNCT
cajgh-4	31	78	increased	increase	VERB
cajgh-4	31	79	cellular	cellular	ADJ
cajgh-4	31	80	calcium	calcium	NOUN
cajgh-4	31	81	level	level	NOUN
cajgh-4	31	82	,	,	PUNCT
cajgh-4	31	83	initiated	initiate	VERB
cajgh-4	31	84	albumin	albumin	ADJ
cajgh-4	31	85	transfer	transfer	NOUN
cajgh-4	31	86	across	across	ADP
cajgh-4	31	87	ec	ec	PROPN
cajgh-4	31	88	monolayer	monolayer	NOUN
cajgh-4	31	89	and	and	CCONJ
cajgh-4	31	90	impaired	impair	VERB
cajgh-4	31	91	ec	ec	PROPN
cajgh-4	31	92	glucose	glucose	NOUN
cajgh-4	31	93	uptake.24,37	uptake.24,37	NOUN
cajgh-4	31	94	-	-	PUNCT
cajgh-4	31	95	39	39	NUM
cajgh-4	31	96	higher	high	ADJ
cajgh-4	31	97	concentrations	concentration	NOUN
cajgh-4	31	98	of	of	ADP
cajgh-4	31	99	aβ	aβ	PRON
cajgh-4	31	100	have	have	AUX
cajgh-4	31	101	been	be	AUX
cajgh-4	31	102	demonstrated	demonstrate	VERB
cajgh-4	31	103	to	to	PART
cajgh-4	31	104	induce	induce	VERB
cajgh-4	31	105	mitochondria	mitochondria	ADJ
cajgh-4	31	106	dysfunction	dysfunction	NOUN
cajgh-4	31	107	,	,	PUNCT
cajgh-4	31	108	nuclear	nuclear	ADJ
cajgh-4	31	109	chromatin	chromatin	NOUN
cajgh-4	31	110	condensation	condensation	NOUN
cajgh-4	31	111	,	,	PUNCT
cajgh-4	31	112	dna	dna	NOUN
cajgh-4	31	113	fragmentation	fragmentation	NOUN
cajgh-4	31	114	,	,	PUNCT
cajgh-4	31	115	and	and	CCONJ
cajgh-4	31	116	significant	significant	ADJ
cajgh-4	31	117	cerebral	cerebral	ADJ
cajgh-4	31	118	endothelial	endothelial	ADJ
cajgh-4	31	119	cell	cell	NOUN
cajgh-4	31	120	death.37,38,40	death.37,38,40	VERB
cajgh-4	31	121	continuous	continuous	ADJ
cajgh-4	31	122	neurovascular	neurovascular	ADJ
cajgh-4	31	123	degeneration	degeneration	NOUN
cajgh-4	31	124	and	and	CCONJ
cajgh-4	31	125	accumulation	accumulation	NOUN
cajgh-4	31	126	of	of	ADP
cajgh-4	31	127	aβ	aβ	NOUN
cajgh-4	31	128	on	on	ADP
cajgh-4	31	129	blood	blood	NOUN
cajgh-4	31	130	vessels	vessel	NOUN
cajgh-4	31	131	resulting	result	VERB
cajgh-4	31	132	in	in	ADP
cajgh-4	31	133	cerebral	cerebral	ADJ
cajgh-4	31	134	amyloid	amyloid	NOUN
cajgh-4	31	135	angiopathy	angiopathy	NOUN
cajgh-4	31	136	is	be	AUX
cajgh-4	31	137	associated	associate	VERB
cajgh-4	31	138	with	with	ADP
cajgh-4	31	139	further	further	ADJ
cajgh-4	31	140	progression	progression	NOUN
cajgh-4	31	141	of	of	ADP
cajgh-4	31	142	the	the	DET
cajgh-4	31	143	disease	disease	NOUN
cajgh-4	31	144	and	and	CCONJ
cajgh-4	31	145	cognitive	cognitive	ADJ
cajgh-4	31	146	decline.14,15,17,41,42	decline.14,15,17,41,42	NOUN
cajgh-4	31	147	2	2	NUM
cajgh-4	31	148	.	.	X
cajgh-4	31	149	oxidative	oxidative	ADJ
cajgh-4	31	150	stress	stress	NOUN
cajgh-4	31	151	,	,	PUNCT
cajgh-4	31	152	inflammation	inflammation	NOUN
cajgh-4	31	153	,	,	PUNCT
cajgh-4	31	154	and	and	CCONJ
cajgh-4	31	155	downstream	downstream	ADJ
cajgh-4	31	156	cell	cell	NOUN
cajgh-4	31	157	signaling	signal	VERB
cajgh-4	31	158	pathways	pathway	NOUN
cajgh-4	31	159	in	in	ADP
cajgh-4	31	160	ad	ad	NOUN
cajgh-4	31	161	there	there	PRON
cajgh-4	31	162	is	be	VERB
cajgh-4	31	163	increasing	increase	VERB
cajgh-4	31	164	evidence	evidence	NOUN
cajgh-4	31	165	that	that	SCONJ
cajgh-4	31	166	oxidative	oxidative	ADJ
cajgh-4	31	167	stress	stress	NOUN
cajgh-4	31	168	is	be	AUX
cajgh-4	31	169	a	a	DET
cajgh-4	31	170	main	main	ADJ
cajgh-4	31	171	mechanism	mechanism	NOUN
cajgh-4	31	172	leading	lead	VERB
cajgh-4	31	173	to	to	ADP
cajgh-4	31	174	cerebrovascular	cerebrovascular	ADJ
cajgh-4	31	175	dysfunction	dysfunction	NOUN
cajgh-4	31	176	in	in	ADP
cajgh-4	31	177	ad	ad	NOUN
cajgh-4	31	178	.	.	PUNCT
cajgh-4	32	1	several	several	ADJ
cajgh-4	32	2	studies	study	NOUN
cajgh-4	32	3	of	of	ADP
cajgh-4	32	4	transgenic	transgenic	NOUN
cajgh-4	32	5	mice	mouse	NOUN
cajgh-4	32	6	over	over	ADP
cajgh-4	32	7	expressing	express	VERB
cajgh-4	32	8	app	app	NOUN
cajgh-4	32	9	have	have	AUX
cajgh-4	32	10	demonstrated	demonstrate	VERB
cajgh-4	32	11	oxidative	oxidative	ADJ
cajgh-4	32	12	damage	damage	NOUN
cajgh-4	32	13	of	of	ADP
cajgh-4	32	14	cecs	cec	NOUN
cajgh-4	32	15	,	,	PUNCT
cajgh-4	32	16	up	up	ADP
cajgh-4	32	17	regulation	regulation	NOUN
cajgh-4	32	18	of	of	ADP
cajgh-4	32	19	superoxide	superoxide	NOUN
cajgh-4	32	20	dismutase	dismutase	NOUN
cajgh-4	32	21	(	(	PUNCT
cajgh-4	32	22	sod	sod	NOUN
cajgh-4	32	23	)	)	PUNCT
cajgh-4	32	24	around	around	ADP
cajgh-4	32	25	brain	brain	NOUN
cajgh-4	32	26	micro	micro	NOUN
cajgh-4	32	27	vessels	vessel	NOUN
cajgh-4	32	28	,	,	PUNCT
cajgh-4	32	29	and	and	CCONJ
cajgh-4	32	30	significant	significant	ADJ
cajgh-4	32	31	impairment	impairment	NOUN
cajgh-4	32	32	of	of	ADP
cajgh-4	32	33	the	the	DET
cajgh-4	32	34	cerebrovascular	cerebrovascular	ADJ
cajgh-4	32	35	functions.43	functions.43	NOUN
cajgh-4	32	36	-	-	PUNCT
cajgh-4	32	37	45	45	NUM
cajgh-4	32	38	at	at	ADP
cajgh-4	32	39	the	the	DET
cajgh-4	32	40	same	same	ADJ
cajgh-4	32	41	time	time	NOUN
cajgh-4	32	42	,	,	PUNCT
cajgh-4	32	43	endothelial	endothelial	ADJ
cajgh-4	32	44	dysfunctions	dysfunction	NOUN
cajgh-4	32	45	were	be	AUX
cajgh-4	32	46	not	not	PART
cajgh-4	32	47	observed	observe	VERB
cajgh-4	32	48	in	in	ADP
cajgh-4	32	49	mice	mouse	NOUN
cajgh-4	32	50	over	over	ADP
cajgh-4	32	51	expressing	express	VERB
cajgh-4	32	52	both	both	PRON
cajgh-4	32	53	app	app	NOUN
cajgh-4	32	54	and	and	CCONJ
cajgh-4	32	55	sod-1	sod-1	ADJ
cajgh-4	32	56	or	or	CCONJ
cajgh-4	32	57	in	in	ADP
cajgh-4	32	58	a	a	DET
cajgh-4	32	59	case	case	NOUN
cajgh-4	32	60	when	when	SCONJ
cajgh-4	32	61	sod	sod	NOUN
cajgh-4	32	62	was	be	AUX
cajgh-4	32	63	directly	directly	ADV
cajgh-4	32	64	applied	apply	VERB
cajgh-4	32	65	to	to	ADP
cajgh-4	32	66	the	the	DET
cajgh-4	32	67	cerebral	cerebral	ADJ
cajgh-4	32	68	cortex	cortex	NOUN
cajgh-4	32	69	of	of	ADP
cajgh-4	32	70	the	the	DET
cajgh-4	32	71	app	app	NOUN
cajgh-4	32	72	mice.44	mice.44	NOUN
cajgh-4	32	73	in	in	ADP
cajgh-4	32	74	-	-	PUNCT
cajgh-4	32	75	vitro	vitro	NOUN
cajgh-4	32	76	,	,	PUNCT
cajgh-4	32	77	treatment	treatment	NOUN
cajgh-4	32	78	of	of	ADP
cajgh-4	32	79	cecs	cec	NOUN
cajgh-4	32	80	with	with	ADP
cajgh-4	32	81	aβ	aβ	NOUN
cajgh-4	32	82	increased	increase	VERB
cajgh-4	32	83	free	free	ADJ
cajgh-4	32	84	radical	radical	ADJ
cajgh-4	32	85	production	production	NOUN
cajgh-4	32	86	and	and	CCONJ
cajgh-4	32	87	this	this	DET
cajgh-4	32	88	effect	effect	NOUN
cajgh-4	32	89	was	be	AUX
cajgh-4	32	90	attenuated	attenuate	VERB
cajgh-4	32	91	by	by	ADP
cajgh-4	32	92	free	free	ADJ
cajgh-4	32	93	radical	radical	ADJ
cajgh-4	32	94	scavengers.43,46	scavengers.43,46	NOUN
cajgh-4	32	95	the	the	DET
cajgh-4	32	96	oxidative	oxidative	ADJ
cajgh-4	32	97	stress	stress	NOUN
cajgh-4	32	98	initiates	initiate	VERB
cajgh-4	32	99	a	a	DET
cajgh-4	32	100	cascade	cascade	NOUN
cajgh-4	32	101	of	of	ADP
cajgh-4	32	102	redox	redox	ADJ
cajgh-4	32	103	reactions	reaction	NOUN
cajgh-4	32	104	which	which	PRON
cajgh-4	32	105	trigger	trigger	NOUN
cajgh-4	32	106	apoptosis	apoptosis	NOUN
cajgh-4	32	107	.	.	PUNCT
cajgh-4	33	1	several	several	ADJ
cajgh-4	33	2	studies	study	NOUN
cajgh-4	33	3	have	have	AUX
cajgh-4	33	4	indicated	indicate	VERB
cajgh-4	33	5	that	that	SCONJ
cajgh-4	33	6	aβ	aβ	NOUN
cajgh-4	33	7	-induced	-induce	VERB
cajgh-4	33	8	cecs	cec	NOUN
cajgh-4	33	9	death	death	NOUN
cajgh-4	33	10	had	have	VERB
cajgh-4	33	11	an	an	DET
cajgh-4	33	12	apoptotic	apoptotic	ADJ
cajgh-4	33	13	nature	nature	NOUN
cajgh-4	33	14	and	and	CCONJ
cajgh-4	33	15	was	be	AUX
cajgh-4	33	16	a	a	DET
cajgh-4	33	17	result	result	NOUN
cajgh-4	33	18	of	of	ADP
cajgh-4	33	19	the	the	DET
cajgh-4	33	20	mitochondria	mitochondria	NOUN
cajgh-4	33	21	dysfunction	dysfunction	NOUN
cajgh-4	33	22	,	,	PUNCT
cajgh-4	33	23	activation	activation	NOUN
cajgh-4	33	24	of	of	ADP
cajgh-4	33	25	a	a	DET
cajgh-4	33	26	caspase	caspase	NOUN
cajgh-4	33	27	upstream	upstream	NOUN
cajgh-4	33	28	,	,	PUNCT
cajgh-4	33	29	and	and	CCONJ
cajgh-4	33	30	proapoptotic	proapoptotic	ADJ
cajgh-4	33	31	proteins	protein	NOUN
cajgh-4	33	32	release38,40,47,48	release38,40,47,48	NOUN
cajgh-4	33	33	induced	induce	VERB
cajgh-4	33	34	oxidative	oxidative	ADJ
cajgh-4	33	35	stress	stress	NOUN
cajgh-4	33	36	also	also	ADV
cajgh-4	33	37	triggers	trigger	VERB
cajgh-4	33	38	downstream	downstream	ADJ
cajgh-4	33	39	kinase	kinase	PROPN
cajgh-4	33	40	cascades	cascade	NOUN
cajgh-4	33	41	leading	lead	VERB
cajgh-4	33	42	to	to	ADP
cajgh-4	33	43	neurovascular	neurovascular	ADJ
cajgh-4	33	44	inflammation.49,50	inflammation.49,50	NOUN
cajgh-4	33	45	study	study	NOUN
cajgh-4	33	46	of	of	ADP
cajgh-4	33	47	the	the	DET
cajgh-4	33	48	microvessels	microvessel	NOUN
cajgh-4	33	49	isolated	isolate	VERB
cajgh-4	33	50	from	from	ADP
cajgh-4	33	51	the	the	DET
cajgh-4	33	52	ad	ad	NOUN
cajgh-4	33	53	patients	patient	NOUN
cajgh-4	33	54	brains	brain	NOUN
cajgh-4	33	55	have	have	AUX
cajgh-4	33	56	revealed	reveal	VERB
cajgh-4	33	57	significantly	significantly	ADV
cajgh-4	33	58	higher	high	ADJ
cajgh-4	33	59	levels	level	NOUN
cajgh-4	33	60	of	of	ADP
cajgh-4	33	61	interleukin-1β	interleukin-1β	PROPN
cajgh-4	33	62	(	(	PUNCT
cajgh-4	33	63	il-1β	il-1β	PROPN
cajgh-4	33	64	)	)	PUNCT
cajgh-4	33	65	,	,	PUNCT
cajgh-4	33	66	il-6	il-6	NOUN
cajgh-4	33	67	,	,	PUNCT
cajgh-4	34	1	tumor	tumor	NOUN
cajgh-4	34	2	necrosis	necrosis	NOUN
cajgh-4	34	3	factor	factor	NOUN
cajgh-4	34	4	α	α	PROPN
cajgh-4	34	5	(	(	PUNCT
cajgh-4	34	6	tnf	tnf	PROPN
cajgh-4	34	7	-	-	PUNCT
cajgh-4	34	8	α	α	NOUN
cajgh-4	34	9	)	)	PUNCT
cajgh-4	34	10	,	,	PUNCT
cajgh-4	34	11	microvessel	microvessel	NOUN
cajgh-4	34	12	-	-	PUNCT
cajgh-4	34	13	associated	associate	VERB
cajgh-4	34	14	monocyte	monocyte	NOUN
cajgh-4	34	15	chemoattractant	chemoattractant	NOUN
cajgh-4	34	16	protein	protein	NOUN
cajgh-4	34	17	(	(	PUNCT
cajgh-4	34	18	mcp-1	mcp-1	NOUN
cajgh-4	34	19	)	)	PUNCT
cajgh-4	34	20	and	and	CCONJ
cajgh-4	34	21	il-1βs.49	il-1βs.49	ADJ
cajgh-4	34	22	in	in	ADP
cajgh-4	34	23	-	-	PUNCT
cajgh-4	34	24	vitro	vitro	X
cajgh-4	34	25	the	the	DET
cajgh-4	34	26	exposure	exposure	NOUN
cajgh-4	34	27	of	of	ADP
cajgh-4	34	28	hbec	hbec	PROPN
cajgh-4	34	29	to	to	PART
cajgh-4	34	30	aβ	aβ	VERB
cajgh-4	34	31	induced	induced	ADJ
cajgh-4	34	32	induction	induction	NOUN
cajgh-4	34	33	of	of	ADP
cajgh-4	34	34	cd40	cd40	PROPN
cajgh-4	34	35	(	(	PUNCT
cajgh-4	34	36	a	a	DET
cajgh-4	34	37	member	member	NOUN
cajgh-4	34	38	of	of	ADP
cajgh-4	34	39	tnf	tnf	PROPN
cajgh-4	34	40	receptor	receptor	NOUN
cajgh-4	34	41	family	family	NOUN
cajgh-4	34	42	)	)	PUNCT
cajgh-4	34	43	,	,	PUNCT
cajgh-4	34	44	secretion	secretion	NOUN
cajgh-4	34	45	of	of	ADP
cajgh-4	34	46	interferon	interferon	ADJ
cajgh-4	34	47	-	-	PUNCT
cajgh-4	34	48	γ	γ	X
cajgh-4	34	49	(	(	PUNCT
cajgh-4	34	50	ifn	ifn	PROPN
cajgh-4	34	51	-	-	PUNCT
cajgh-4	34	52	γ	γ	NOUN
cajgh-4	34	53	)	)	PUNCT
cajgh-4	34	54	and	and	CCONJ
cajgh-4	34	55	il-1β	il-1β	PROPN
cajgh-4	34	56	,	,	PUNCT
cajgh-4	34	57	expression	expression	NOUN
cajgh-4	34	58	of	of	ADP
cajgh-4	34	59	of	of	ADP
cajgh-4	34	60	ifn	ifn	PROPN
cajgh-4	34	61	-	-	PUNCT
cajgh-4	34	62	γ	γ	NOUN
cajgh-4	34	63	receptor	receptor	NOUN
cajgh-4	34	64	(	(	PUNCT
cajgh-4	34	65	ifn	ifn	PROPN
cajgh-4	34	66	-	-	PUNCT
cajgh-4	34	67	γr	γr	PROPN
cajgh-4	34	68	)	)	PUNCT
cajgh-4	34	69	,	,	PUNCT
cajgh-4	34	70	and	and	CCONJ
cajgh-4	34	71	triggered	trigger	VERB
cajgh-4	34	72	inflammatory	inflammatory	ADJ
cajgh-4	34	73	genes	gene	NOUN
cajgh-4	34	74	mcp-1	mcp-1	NOUN
cajgh-4	34	75	,	,	PUNCT
cajgh-4	34	76	gro	gro	PROPN
cajgh-4	34	77	,	,	PUNCT
cajgh-4	34	78	il-1β	il-1β	PROPN
cajgh-4	34	79	and	and	CCONJ
cajgh-4	34	80	il-6	il-6	NOUN
cajgh-4	34	81	expression	expression	NOUN
cajgh-4	34	82	via	via	ADP
cajgh-4	34	83	jnk	jnk	PROPN
cajgh-4	34	84	-	-	PUNCT
cajgh-4	34	85	ap1	ap1	PROPN
cajgh-4	34	86	signaling	signaling	ADJ
cajgh-4	34	87	pathway.50	pathway.50	NOUN
cajgh-4	34	88	-	-	SYM
cajgh-4	34	89	52	52	NUM
cajgh-4	34	90	aβ	aβ	NOUN
cajgh-4	34	91	-	-	PUNCT
cajgh-4	34	92	induced	induce	VERB
cajgh-4	34	93	oxidative	oxidative	ADJ
cajgh-4	34	94	stress	stress	NOUN
cajgh-4	34	95	in	in	ADP
cajgh-4	34	96	cerebral	cerebral	ADJ
cajgh-4	34	97	epithelium	epithelium	NOUN
cajgh-4	34	98	is	be	AUX
cajgh-4	34	99	associated	associate	VERB
cajgh-4	34	100	with	with	ADP
cajgh-4	34	101	overproduction	overproduction	NOUN
cajgh-4	34	102	of	of	ADP
cajgh-4	34	103	reactive	reactive	ADJ
cajgh-4	34	104	oxygen	oxygen	NOUN
cajgh-4	34	105	species	specie	NOUN
cajgh-4	34	106	(	(	PUNCT
cajgh-4	34	107	ros).20,53	ros).20,53	NOUN
cajgh-4	34	108	-	-	SYM
cajgh-4	34	109	55	55	NUM
cajgh-4	34	110	ros	ro	NOUN
cajgh-4	34	111	can	can	AUX
cajgh-4	34	112	be	be	AUX
cajgh-4	34	113	generated	generate	VERB
cajgh-4	34	114	by	by	ADP
cajgh-4	34	115	several	several	ADJ
cajgh-4	34	116	enzymatic	enzymatic	ADJ
cajgh-4	34	117	systems	system	NOUN
cajgh-4	34	118	,	,	PUNCT
cajgh-4	34	119	but	but	CCONJ
cajgh-4	34	120	there	there	PRON
cajgh-4	34	121	is	be	VERB
cajgh-4	34	122	evidence	evidence	NOUN
cajgh-4	34	123	that	that	SCONJ
cajgh-4	34	124	superoxide	superoxide	NOUN
cajgh-4	34	125	-	-	PUNCT
cajgh-4	34	126	producing	produce	VERB
cajgh-4	34	127	enzyme	enzyme	NOUN
cajgh-4	34	128	nadph	nadph	ADJ
cajgh-4	34	129	oxidase	oxidase	NOUN
cajgh-4	34	130	a	a	PRON
cajgh-4	34	131	is	be	AUX
cajgh-4	34	132	major	major	ADJ
cajgh-4	34	133	source	source	NOUN
cajgh-4	34	134	of	of	ADP
cajgh-4	34	135	ros	ros	PROPN
cajgh-4	34	136	in	in	ADP
cajgh-4	34	137	the	the	DET
cajgh-4	34	138	brain	brain	NOUN
cajgh-4	34	139	blood	blood	NOUN
cajgh-4	34	140	vessels.54	vessels.54	PROPN
cajgh-4	34	141	-	-	SYM
cajgh-4	34	142	56	56	NUM
cajgh-4	34	143	in	in	ADP
cajgh-4	34	144	a	a	DET
cajgh-4	34	145	model	model	NOUN
cajgh-4	34	146	of	of	ADP
cajgh-4	34	147	ad	ad	NOUN
cajgh-4	34	148	,	,	PUNCT
cajgh-4	34	149	inhibition	inhibition	NOUN
cajgh-4	34	150	of	of	ADP
cajgh-4	34	151	nadph	nadph	ADJ
cajgh-4	34	152	oxidase	oxidase	NOUN
cajgh-4	34	153	has	have	AUX
cajgh-4	34	154	been	be	AUX
cajgh-4	34	155	found	find	VERB
cajgh-4	34	156	to	to	PART
cajgh-4	34	157	abrogate	abrogate	VERB
cajgh-4	34	158	aβ	aβ	DET
cajgh-4	34	159	induced	induce	VERB
cajgh-4	34	160	ros	ros	PROPN
cajgh-4	34	161	production	production	NOUN
cajgh-4	34	162	and	and	CCONJ
cajgh-4	34	163	alteration	alteration	NOUN
cajgh-4	34	164	of	of	ADP
cajgh-4	34	165	cerebrovascular	cerebrovascular	ADJ
cajgh-4	34	166	functions.54	functions.54	PROPN
cajgh-4	34	167	app	app	NOUN
cajgh-4	34	168	transgenic	transgenic	NOUN
cajgh-4	34	169	mice	mouse	NOUN
cajgh-4	34	170	lacking	lack	VERB
cajgh-4	34	171	the	the	DET
cajgh-4	34	172	nadph	nadph	ADJ
cajgh-4	34	173	oxidase	oxidase	NOUN
cajgh-4	34	174	subunits	subunit	NOUN
cajgh-4	34	175	gp91phox	gp91phox	PROPN
cajgh-4	34	176	or	or	CCONJ
cajgh-4	34	177	nox2	nox2	PROPN
cajgh-4	34	178	did	do	AUX
cajgh-4	34	179	not	not	PART
cajgh-4	34	180	develop	develop	VERB
cajgh-4	34	181	oxidative	oxidative	ADJ
cajgh-4	34	182	stress	stress	NOUN
cajgh-4	34	183	,	,	PUNCT
cajgh-4	34	184	cerebrovascular	cerebrovascular	ADJ
cajgh-4	34	185	dysfunction	dysfunction	NOUN
cajgh-4	34	186	,	,	PUNCT
cajgh-4	34	187	and	and	CCONJ
cajgh-4	34	188	behavioral	behavioral	ADJ
cajgh-4	34	189	deficits.54,55	deficits.54,55	NOUN
cajgh-4	34	190	recent	recent	ADJ
cajgh-4	34	191	studies	study	NOUN
cajgh-4	34	192	have	have	AUX
cajgh-4	34	193	indicated	indicate	VERB
cajgh-4	34	194	that	that	SCONJ
cajgh-4	34	195	the	the	DET
cajgh-4	34	196	receptor	receptor	NOUN
cajgh-4	34	197	for	for	ADP
cajgh-4	34	198	advanced	advanced	ADJ
cajgh-4	34	199	glycation	glycation	NOUN
cajgh-4	34	200	endproducts	endproduct	NOUN
cajgh-4	34	201	(	(	PUNCT
cajgh-4	34	202	rage	rage	NOUN
cajgh-4	34	203	)	)	PUNCT
cajgh-4	34	204	is	be	AUX
cajgh-4	34	205	a	a	DET
cajgh-4	34	206	binding	bind	VERB
cajgh-4	34	207	site	site	NOUN
cajgh-4	34	208	for	for	ADP
cajgh-4	34	209	aβ.57	aβ.57	PROPN
cajgh-4	34	210	-	-	SYM
cajgh-4	34	211	62	62	NUM
cajgh-4	34	212	rage	rage	NOUN
cajgh-4	34	213	is	be	AUX
cajgh-4	34	214	a	a	DET
cajgh-4	34	215	multiligand	multiligand	ADJ
cajgh-4	34	216	cell	cell	NOUN
cajgh-4	34	217	surface	surface	NOUN
cajgh-4	34	218	receptor	receptor	NOUN
cajgh-4	34	219	which	which	PRON
cajgh-4	34	220	is	be	AUX
cajgh-4	34	221	normally	normally	ADV
cajgh-4	34	222	expressed	express	VERB
cajgh-4	34	223	in	in	ADP
cajgh-4	34	224	brain	brain	NOUN
cajgh-4	34	225	endothelium	endothelium	NOUN
cajgh-4	34	226	and	and	CCONJ
cajgh-4	34	227	,	,	PUNCT
cajgh-4	34	228	at	at	ADP
cajgh-4	34	229	low	low	ADJ
cajgh-4	34	230	levels	level	NOUN
cajgh-4	34	231	,	,	PUNCT
cajgh-4	34	232	in	in	ADP
cajgh-4	34	233	microglia	microglia	NOUN
cajgh-4	34	234	and	and	CCONJ
cajgh-4	34	235	neurons.15,60,61	neurons.15,60,61	NOUN
cajgh-4	34	236	however	however	ADV
cajgh-4	34	237	,	,	PUNCT
cajgh-4	34	238	in	in	ADP
cajgh-4	34	239	ad	ad	NOUN
cajgh-4	34	240	brains	brain	NOUN
cajgh-4	34	241	rage	rage	NOUN
cajgh-4	34	242	expression	expression	NOUN
cajgh-4	34	243	is	be	AUX
cajgh-4	34	244	increased	increase	VERB
cajgh-4	34	245	by	by	ADP
cajgh-4	34	246	several	several	ADJ
cajgh-4	34	247	-	-	PUNCT
cajgh-4	34	248	fold	fold	ADJ
cajgh-4	34	249	in	in	ADP
cajgh-4	34	250	cerebral	cerebral	ADJ
cajgh-4	34	251	endothelial	endothelial	ADJ
cajgh-4	34	252	cells	cell	NOUN
cajgh-4	34	253	,	,	PUNCT
cajgh-4	34	254	astrocytes	astrocyte	NOUN
cajgh-4	34	255	,	,	PUNCT
cajgh-4	34	256	microglia	microglia	ADJ
cajgh-4	34	257	,	,	PUNCT
cajgh-4	34	258	and	and	CCONJ
cajgh-4	34	259	neurons.60,61	neurons.60,61	NOUN
cajgh-4	34	260	ros	ros	PROPN
cajgh-4	34	261	have	have	AUX
cajgh-4	34	262	been	be	AUX
cajgh-4	34	263	reported	report	VERB
cajgh-4	34	264	to	to	PART
cajgh-4	34	265	be	be	AUX
cajgh-4	34	266	generated	generate	VERB
cajgh-4	34	267	by	by	ADP
cajgh-4	34	268	nadph	nadph	ADJ
cajgh-4	34	269	oxidase	oxidase	NOUN
cajgh-4	34	270	through	through	ADP
cajgh-4	34	271	the	the	DET
cajgh-4	34	272	rage	rage	NOUN
cajgh-4	34	273	in	in	ADP
cajgh-4	34	274	endothelial	endothelial	ADJ
cajgh-4	34	275	cells.62,63	cells.62,63	ADJ
cajgh-4	34	276	inhibition	inhibition	NOUN
cajgh-4	34	277	studies	study	NOUN
cajgh-4	34	278	have	have	AUX
cajgh-4	34	279	indicated	indicate	VERB
cajgh-4	34	280	that	that	SCONJ
cajgh-4	34	281	anti	anti	ADJ
cajgh-4	34	282	-	-	ADJ
cajgh-4	34	283	rage	rage	ADJ
cajgh-4	34	284	igg	igg	NOUN
cajgh-4	34	285	significantly	significantly	ADV
cajgh-4	34	286	suppressed	suppress	VERB
cajgh-4	34	287	oxidative	oxidative	ADJ
cajgh-4	34	288	stress	stress	NOUN
cajgh-4	34	289	and	and	CCONJ
cajgh-4	34	290	inflammation	inflammation	NOUN
cajgh-4	34	291	induced	induce	VERB
cajgh-4	34	292	by	by	ADP
cajgh-4	34	293	aβ	aβ	PRON
cajgh-4	34	294	in	in	ADP
cajgh-4	34	295	vascular	vascular	ADJ
cajgh-4	34	296	cells	cell	NOUN
cajgh-4	34	297	and	and	CCONJ
cajgh-4	34	298	neurons.57	neurons.57	PROPN
cajgh-4	34	299	rage	rage	NOUN
cajgh-4	34	300	binding	bind	VERB
cajgh-4	34	301	to	to	ADP
cajgh-4	34	302	aβ	aβ	NOUN
cajgh-4	34	303	has	have	AUX
cajgh-4	34	304	been	be	AUX
cajgh-4	34	305	also	also	ADV
cajgh-4	34	306	demonstrated	demonstrate	VERB
cajgh-4	34	307	to	to	PART
cajgh-4	34	308	regulate	regulate	VERB
cajgh-4	34	309	aβ	aβ	DET
cajgh-4	34	310	transport	transport	NOUN
cajgh-4	34	311	across	across	ADP
cajgh-4	34	312	bbb	bbb	PROPN
cajgh-4	34	313	,	,	PUNCT
cajgh-4	34	314	upregulate	upregulate	VERB
cajgh-4	34	315	pro	pro	ADJ
cajgh-4	34	316	-	-	ADJ
cajgh-4	34	317	inflammatory	inflammatory	ADJ
cajgh-4	34	318	cytokines	cytokine	NOUN
cajgh-4	34	319	and	and	CCONJ
cajgh-4	34	320	adhesion	adhesion	NOUN
cajgh-4	34	321	molecules	molecule	NOUN
cajgh-4	34	322	in	in	ADP
cajgh-4	34	323	cecs	cec	NOUN
cajgh-4	34	324	,	,	PUNCT
cajgh-4	34	325	and	and	CCONJ
cajgh-4	34	326	contribute	contribute	VERB
cajgh-4	34	327	to	to	ADP
cajgh-4	34	328	the	the	DET
cajgh-4	34	329	transport	transport	NOUN
cajgh-4	34	330	of	of	ADP
cajgh-4	34	331	aβ	aβ	PRON
cajgh-4	34	332	from	from	ADP
cajgh-4	34	333	the	the	DET
cajgh-4	34	334	cell	cell	NOUN
cajgh-4	34	335	surface	surface	NOUN
cajgh-4	34	336	into	into	ADP
cajgh-4	34	337	the	the	DET
cajgh-4	34	338	intracellular	intracellular	ADJ
cajgh-4	34	339	space	space	NOUN
cajgh-4	34	340	in	in	ADP
cajgh-4	34	341	cortical	cortical	ADJ
cajgh-4	34	342	neurons.61,64,65	neurons.61,64,65	PROPN
cajgh-4	34	343	aβ	aβ	ADV
cajgh-4	34	344	-	-	PUNCT
cajgh-4	34	345	induced	induce	VERB
cajgh-4	34	346	cytotoxic	cytotoxic	ADJ
cajgh-4	34	347	effects	effect	NOUN
cajgh-4	34	348	are	be	AUX
cajgh-4	34	349	also	also	ADV
cajgh-4	34	350	associated	associate	VERB
cajgh-4	34	351	with	with	ADP
cajgh-4	34	352	the	the	DET
cajgh-4	34	353	activation	activation	NOUN
cajgh-4	34	354	of	of	ADP
cajgh-4	34	355	mapk	mapk	NOUN
cajgh-4	34	356	/	/	SYM
cajgh-4	34	357	erk1/2	erk1/2	PROPN
cajgh-4	34	358	cascade	cascade	NOUN
cajgh-4	34	359	and	and	CCONJ
cajgh-4	34	360	that	that	SCONJ
cajgh-4	34	361	activated	activate	VERB
cajgh-4	34	362	erks	erk	NOUN
cajgh-4	34	363	(	(	PUNCT
cajgh-4	34	364	extracellular	extracellular	ADJ
cajgh-4	34	365	-	-	PUNCT
cajgh-4	34	366	signal	signal	NOUN
cajgh-4	34	367	-	-	PUNCT
cajgh-4	34	368	regulated	regulate	VERB
cajgh-4	34	369	kinases	kinase	NOUN
cajgh-4	34	370	)	)	PUNCT
cajgh-4	34	371	is	be	AUX
cajgh-4	34	372	the	the	DET
cajgh-4	34	373	central	central	ADJ
cajgh-4	34	374	target	target	NOUN
cajgh-4	34	375	of	of	ADP
cajgh-4	34	376	rage.62,66	rage.62,66	NOUN
cajgh-4	34	377	-	-	PUNCT
cajgh-4	34	378	72	72	NUM
cajgh-4	34	379	the	the	DET
cajgh-4	34	380	erks	erk	NOUN
cajgh-4	34	381	are	be	AUX
cajgh-4	34	382	widely	widely	ADV
cajgh-4	34	383	expressed	express	VERB
cajgh-4	34	384	protein	protein	NOUN
cajgh-4	34	385	kinases	kinase	NOUN
cajgh-4	34	386	,	,	PUNCT
cajgh-4	34	387	part	part	NOUN
cajgh-4	34	388	of	of	ADP
cajgh-4	34	389	a	a	DET
cajgh-4	34	390	signal	signal	ADJ
cajgh-4	34	391	transduction	transduction	NOUN
cajgh-4	34	392	system	system	NOUN
cajgh-4	34	393	,	,	PUNCT
cajgh-4	34	394	through	through	ADP
cajgh-4	34	395	which	which	PRON
cajgh-4	34	396	extracellular	extracellular	ADJ
cajgh-4	34	397	stimuli	stimulus	NOUN
cajgh-4	34	398	are	be	AUX
cajgh-4	34	399	transduced	transduce	VERB
cajgh-4	34	400	.	.	PUNCT
cajgh-4	35	1	activation	activation	NOUN
cajgh-4	35	2	of	of	ADP
cajgh-4	35	3	the	the	DET
cajgh-4	35	4	erks	erk	NOUN
cajgh-4	35	5	occurs	occur	VERB
cajgh-4	35	6	in	in	ADP
cajgh-4	35	7	response	response	NOUN
cajgh-4	35	8	to	to	ADP
cajgh-4	35	9	growth	growth	NOUN
cajgh-4	35	10	factor	factor	NOUN
cajgh-4	35	11	stimulation	stimulation	NOUN
cajgh-4	35	12	,	,	PUNCT
cajgh-4	35	13	cytokines	cytokine	NOUN
cajgh-4	35	14	,	,	PUNCT
cajgh-4	35	15	virus	virus	NOUN
cajgh-4	35	16	infection	infection	NOUN
cajgh-4	35	17	,	,	PUNCT
cajgh-4	35	18	transforming	transform	VERB
cajgh-4	35	19	agents	agent	NOUN
cajgh-4	35	20	,	,	PUNCT
cajgh-4	35	21	carcinogens	carcinogen	NOUN
cajgh-4	35	22	,	,	PUNCT
cajgh-4	35	23	and	and	CCONJ
cajgh-4	35	24	after	after	SCONJ
cajgh-4	35	25	the	the	DET
cajgh-4	35	26	activation	activation	NOUN
cajgh-4	35	27	of	of	ADP
cajgh-4	35	28	high	high	ADJ
cajgh-4	35	29	-	-	PUNCT
cajgh-4	35	30	affinity	affinity	NOUN
cajgh-4	35	31	igg	igg	NOUN
cajgh-4	35	32	receptors.71	receptors.71	NOUN
cajgh-4	35	33	erks	erk	NOUN
cajgh-4	35	34	have	have	AUX
cajgh-4	35	35	been	be	AUX
cajgh-4	35	36	implicated	implicate	VERB
cajgh-4	35	37	in	in	ADP
cajgh-4	35	38	diverse	diverse	ADJ
cajgh-4	35	39	cellular	cellular	ADJ
cajgh-4	35	40	responses	response	NOUN
cajgh-4	35	41	such	such	ADJ
cajgh-4	35	42	as	as	ADP
cajgh-4	35	43	mitogenesis	mitogenesis	NOUN
cajgh-4	35	44	,	,	PUNCT
cajgh-4	35	45	differentiation	differentiation	NOUN
cajgh-4	35	46	,	,	PUNCT
cajgh-4	35	47	inflammation	inflammation	NOUN
cajgh-4	35	48	and	and	CCONJ
cajgh-4	35	49	cytotoxicity	cytotoxicity	NOUN
cajgh-4	35	50	,	,	PUNCT
cajgh-4	35	51	and	and	CCONJ
cajgh-4	35	52	the	the	DET
cajgh-4	35	53	overproduction	overproduction	NOUN
cajgh-4	35	54	of	of	ADP
cajgh-4	35	55	this	this	DET
cajgh-4	35	56	enzyme	enzyme	NOUN
cajgh-4	35	57	is	be	AUX
cajgh-4	35	58	involved	involve	VERB
cajgh-4	35	59	in	in	ADP
cajgh-4	35	60	many	many	ADJ
cajgh-4	35	61	neurodegenerative	neurodegenerative	ADJ
cajgh-4	35	62	diseases	disease	NOUN
cajgh-4	35	63	,	,	PUNCT
cajgh-4	35	64	including	include	VERB
cajgh-4	35	65	ad.67,73,74	ad.67,73,74	NOUN
cajgh-4	35	66	thus	thus	ADV
cajgh-4	35	67	,	,	PUNCT
cajgh-4	35	68	nadph	nadph	ADJ
cajgh-4	35	69	oxidase	oxidase	NOUN
cajgh-4	35	70	,	,	PUNCT
cajgh-4	35	71	erks	erk	NOUN
cajgh-4	35	72	and	and	CCONJ
cajgh-4	35	73	rage	rage	NOUN
cajgh-4	35	74	have	have	AUX
cajgh-4	35	75	been	be	AUX
cajgh-4	35	76	suggested	suggest	VERB
cajgh-4	35	77	to	to	PART
cajgh-4	35	78	be	be	AUX
cajgh-4	35	79	important	important	ADJ
cajgh-4	35	80	therapeutic	therapeutic	ADJ
cajgh-4	35	81	targets	target	NOUN
cajgh-4	35	82	in	in	ADP
cajgh-4	35	83	ad	ad	NOUN
cajgh-4	35	84	.	.	PUNCT
cajgh-4	36	1	3	3	X
cajgh-4	36	2	.	.	X
cajgh-4	36	3	permeability	permeability	NOUN
cajgh-4	36	4	of	of	ADP
cajgh-4	36	5	cerebral	cerebral	ADJ
cajgh-4	36	6	endothelium	endothelium	NOUN
cajgh-4	36	7	in	in	ADP
cajgh-4	36	8	ad	ad	NOUN
cajgh-4	36	9	in	in	ADP
cajgh-4	36	10	the	the	DET
cajgh-4	36	11	ad	ad	NOUN
cajgh-4	36	12	,	,	PUNCT
cajgh-4	36	13	an	an	DET
cajgh-4	36	14	increased	increase	VERB
cajgh-4	36	15	deposition	deposition	NOUN
cajgh-4	36	16	of	of	ADP
cajgh-4	36	17	aβ	aβ	PRON
cajgh-4	36	18	in	in	ADP
cajgh-4	36	19	the	the	DET
cajgh-4	36	20	cerebral	cerebral	ADJ
cajgh-4	36	21	vasculature	vasculature	NOUN
cajgh-4	36	22	has	have	AUX
cajgh-4	36	23	been	be	AUX
cajgh-4	36	24	found	find	VERB
cajgh-4	36	25	to	to	PART
cajgh-4	36	26	correlate	correlate	VERB
cajgh-4	36	27	with	with	ADP
cajgh-4	36	28	accumulation	accumulation	NOUN
cajgh-4	36	29	of	of	ADP
cajgh-4	36	30	monocytes	monocyte	NOUN
cajgh-4	36	31	in	in	ADP
cajgh-4	36	32	the	the	DET
cajgh-4	36	33	vessel	vessel	NOUN
cajgh-4	36	34	walls	wall	NOUN
cajgh-4	36	35	and	and	CCONJ
cajgh-4	36	36	of	of	ADP
cajgh-4	36	37	activated	activate	VERB
cajgh-4	36	38	microglia	microglia	ADJ
cajgh-4	36	39	cells	cell	NOUN
cajgh-4	36	40	in	in	ADP
cajgh-4	36	41	the	the	DET
cajgh-4	36	42	adjacent	adjacent	ADJ
cajgh-4	36	43	parenchyma.75	parenchyma.75	PROPN
cajgh-4	36	44	-	-	PUNCT
cajgh-4	36	45	77	77	PROPN
cajgh-4	36	46	since	since	SCONJ
cajgh-4	36	47	peripheral	peripheral	ADJ
cajgh-4	36	48	monocytes	monocyte	NOUN
cajgh-4	36	49	can	can	AUX
cajgh-4	36	50	migrate	migrate	VERB
cajgh-4	36	51	across	across	ADP
cajgh-4	36	52	the	the	DET
cajgh-4	36	53	bbb	bbb	NOUN
cajgh-4	36	54	and	and	CCONJ
cajgh-4	36	55	differentiate	differentiate	VERB
cajgh-4	36	56	into	into	ADP
cajgh-4	36	57	microglia,78	microglia,78	PROPN
cajgh-4	36	58	which	which	PRON
cajgh-4	36	59	,	,	PUNCT
cajgh-4	36	60	in	in	ADP
cajgh-4	36	61	turn	turn	NOUN
cajgh-4	36	62	,	,	PUNCT
cajgh-4	36	63	drives	drive	VERB
cajgh-4	36	64	the	the	DET
cajgh-4	36	65	disease	disease	NOUN
cajgh-4	36	66	development	development	NOUN
cajgh-4	36	67	towards	towards	ADP
cajgh-4	36	68	exacerbation	exacerbation	NOUN
cajgh-4	36	69	of	of	ADP
cajgh-4	36	70	the	the	DET
cajgh-4	36	71	oxidative	oxidative	ADJ
cajgh-4	36	72	and	and	CCONJ
cajgh-4	36	73	inflammatory	inflammatory	ADJ
cajgh-4	36	74	conditions	condition	NOUN
cajgh-4	36	75	characteristic	characteristic	ADJ
cajgh-4	36	76	of	of	ADP
cajgh-4	36	77	the	the	DET
cajgh-4	36	78	ad	ad	NOUN
cajgh-4	36	79	brain	brain	NOUN
cajgh-4	36	80	,	,	PUNCT
cajgh-4	36	81	several	several	ADJ
cajgh-4	36	82	research	research	NOUN
cajgh-4	36	83	groups	group	NOUN
cajgh-4	36	84	have	have	AUX
cajgh-4	36	85	attempted	attempt	VERB
cajgh-4	36	86	to	to	PART
cajgh-4	36	87	demonstrate	demonstrate	VERB
cajgh-4	36	88	the	the	DET
cajgh-4	36	89	direct	direct	ADJ
cajgh-4	36	90	effect	effect	NOUN
cajgh-4	36	91	of	of	ADP
cajgh-4	36	92	aβ	aβ	NOUN
cajgh-4	36	93	on	on	ADP
cajgh-4	36	94	endothelial	endothelial	ADJ
cajgh-4	36	95	functions	function	NOUN
cajgh-4	36	96	leading	lead	VERB
cajgh-4	36	97	to	to	ADP
cajgh-4	36	98	enhanced	enhanced	ADJ
cajgh-4	36	99	transmigration	transmigration	NOUN
cajgh-4	36	100	of	of	ADP
cajgh-4	36	101	monocytes	monocyte	NOUN
cajgh-4	36	102	.	.	PUNCT
cajgh-4	37	1	in	in	ADP
cajgh-4	37	2	-	-	PUNCT
cajgh-4	37	3	vitro	vitro	X
cajgh-4	37	4	studies	study	NOUN
cajgh-4	37	5	have	have	AUX
cajgh-4	37	6	shown	show	VERB
cajgh-4	37	7	that	that	PRON
cajgh-4	37	8	soluble	soluble	ADJ
cajgh-4	37	9	aβ	aβ	NOUN
cajgh-4	37	10	interactions	interaction	NOUN
cajgh-4	37	11	with	with	ADP
cajgh-4	37	12	rage	rage	NOUN
cajgh-4	37	13	and	and	CCONJ
cajgh-4	37	14	platelet	platelet	ADJ
cajgh-4	37	15	-	-	PUNCT
cajgh-4	37	16	endothelial	endothelial	ADJ
cajgh-4	37	17	cell	cell	NOUN
cajgh-4	37	18	adhesion	adhesion	NOUN
cajgh-4	37	19	molecule-1	molecule-1	PROPN
cajgh-4	37	20	(	(	PUNCT
cajgh-4	37	21	pecam-1	pecam-1	NUM
cajgh-4	37	22	)	)	PUNCT
cajgh-4	37	23	at	at	ADP
cajgh-4	37	24	the	the	DET
cajgh-4	37	25	apical	apical	ADJ
cajgh-4	37	26	surface	surface	NOUN
cajgh-4	37	27	and	and	CCONJ
cajgh-4	37	28	basolateral	basolateral	ADJ
cajgh-4	37	29	sides	side	NOUN
cajgh-4	37	30	of	of	ADP
cajgh-4	37	31	monolayer	monolayer	NOUN
cajgh-4	37	32	of	of	ADP
cajgh-4	37	33	brain	brain	NOUN
cajgh-4	37	34	endothelial	endothelial	NOUN
cajgh-4	37	35	cells	cell	NOUN
cajgh-4	37	36	increased	increase	VERB
cajgh-4	37	37	transendothelial	transendothelial	NOUN
cajgh-4	37	38	migration	migration	NOUN
cajgh-4	37	39	of	of	ADP
cajgh-4	37	40	monocytic	monocytic	ADJ
cajgh-4	37	41	cells.79	cells.79	PROPN
cajgh-4	37	42	-	-	PUNCT
cajgh-4	37	43	81	81	NUM
cajgh-4	37	44	based	base	VERB
cajgh-4	37	45	on	on	ADP
cajgh-4	37	46	the	the	DET
cajgh-4	37	47	observation	observation	NOUN
cajgh-4	37	48	that	that	SCONJ
cajgh-4	37	49	the	the	DET
cajgh-4	37	50	permeability	permeability	NOUN
cajgh-4	37	51	of	of	ADP
cajgh-4	37	52	the	the	DET
cajgh-4	37	53	monolayer	monolayer	NOUN
cajgh-4	37	54	toward	toward	ADP
cajgh-4	37	55	dextran	dextran	NOUN
cajgh-4	37	56	and	and	CCONJ
cajgh-4	37	57	inulin	inulin	NOUN
cajgh-4	37	58	in	in	ADP
cajgh-4	37	59	the	the	DET
cajgh-4	37	60	presence	presence	NOUN
cajgh-4	37	61	or	or	CCONJ
cajgh-4	37	62	absence	absence	NOUN
cajgh-4	37	63	of	of	ADP
cajgh-4	37	64	aβ42	aβ42	PROPN
cajgh-4	37	65	remained	remain	VERB
cajgh-4	37	66	unaltered,79	unaltered,79	NOUN
cajgh-4	37	67	it	it	PRON
cajgh-4	37	68	has	have	AUX
cajgh-4	37	69	been	be	AUX
cajgh-4	37	70	concluded	conclude	VERB
cajgh-4	37	71	that	that	SCONJ
cajgh-4	37	72	enhanced	enhance	VERB
cajgh-4	37	73	transmigration	transmigration	NOUN
cajgh-4	37	74	of	of	ADP
cajgh-4	37	75	monocytes	monocyte	NOUN
cajgh-4	37	76	induced	induce	VERB
cajgh-4	37	77	by	by	ADP
cajgh-4	37	78	aβ	aβ	PRON
cajgh-4	37	79	is	be	AUX
cajgh-4	37	80	not	not	PART
cajgh-4	37	81	only	only	ADV
cajgh-4	37	82	due	due	ADJ
cajgh-4	37	83	to	to	ADP
cajgh-4	37	84	nonspecific	nonspecific	ADJ
cajgh-4	37	85	disruption	disruption	NOUN
cajgh-4	37	86	of	of	ADP
cajgh-4	37	87	the	the	DET
cajgh-4	37	88	barrier	barrier	NOUN
cajgh-4	37	89	properties	property	NOUN
cajgh-4	37	90	of	of	ADP
cajgh-4	37	91	the	the	DET
cajgh-4	37	92	endothelial	endothelial	ADJ
cajgh-4	37	93	layer	layer	NOUN
cajgh-4	37	94	,	,	PUNCT
cajgh-4	37	95	but	but	CCONJ
cajgh-4	37	96	also	also	ADV
cajgh-4	37	97	is	be	AUX
cajgh-4	37	98	a	a	DET
cajgh-4	37	99	consequence	consequence	NOUN
cajgh-4	37	100	of	of	ADP
cajgh-4	37	101	aβ	aβ	DET
cajgh-4	37	102	induced	induce	VERB
cajgh-4	37	103	expression	expression	NOUN
cajgh-4	37	104	of	of	ADP
cajgh-4	37	105	the	the	DET
cajgh-4	37	106	chemokines	chemokine	NOUN
cajgh-4	37	107	and	and	CCONJ
cajgh-4	37	108	adhesion	adhesion	NOUN
cajgh-4	37	109	molecules	molecule	NOUN
cajgh-4	37	110	.	.	PUNCT
cajgh-4	38	1	since	since	SCONJ
cajgh-4	38	2	primary	primary	ADJ
cajgh-4	38	3	capture	capture	NOUN
cajgh-4	38	4	of	of	ADP
cajgh-4	38	5	the	the	DET
cajgh-4	38	6	monocytes	monocyte	NOUN
cajgh-4	38	7	to	to	ADP
cajgh-4	38	8	endothelium	endothelium	NOUN
cajgh-4	38	9	and	and	CCONJ
cajgh-4	38	10	rolling	rolling	NOUN
cajgh-4	38	11	are	be	AUX
cajgh-4	38	12	mediated	mediate	VERB
cajgh-4	38	13	by	by	ADP
cajgh-4	38	14	tethering	tether	VERB
cajgh-4	38	15	on	on	ADP
cajgh-4	38	16	selectins	selectin	NOUN
cajgh-4	38	17	and	and	CCONJ
cajgh-4	38	18	selectin	selectin	ADJ
cajgh-4	38	19	ligands,82	ligands,82	NOUN
cajgh-4	38	20	-	-	PUNCT
cajgh-4	38	21	84	84	NUM
cajgh-4	38	22	the	the	DET
cajgh-4	38	23	expression	expression	NOUN
cajgh-4	38	24	of	of	ADP
cajgh-4	38	25	adhesion	adhesion	NOUN
cajgh-4	38	26	molecules	molecule	NOUN
cajgh-4	38	27	,	,	PUNCT
cajgh-4	38	28	mechanical	mechanical	ADJ
cajgh-4	38	29	properties	property	NOUN
cajgh-4	38	30	of	of	ADP
cajgh-4	38	31	the	the	DET
cajgh-4	38	32	membranes	membrane	NOUN
cajgh-4	38	33	(	(	PUNCT
cajgh-4	38	34	fluidity	fluidity	NOUN
cajgh-4	38	35	,	,	PUNCT
cajgh-4	38	36	elasticity	elasticity	NOUN
cajgh-4	38	37	)	)	PUNCT
cajgh-4	38	38	and	and	CCONJ
cajgh-4	38	39	membrane	membrane	NOUN
cajgh-4	38	40	-	-	PUNCT
cajgh-4	38	41	cytoskeleton	cytoskeleton	NOUN
cajgh-4	38	42	interactions	interaction	NOUN
cajgh-4	38	43	are	be	AUX
cajgh-4	38	44	critical	critical	ADJ
cajgh-4	38	45	for	for	ADP
cajgh-4	38	46	transmigration.85	transmigration.85	ADJ
cajgh-4	38	47	-	-	PUNCT
cajgh-4	38	48	90	90	NUM
cajgh-4	38	49	atomic	atomic	ADJ
cajgh-4	38	50	force	force	NOUN
cajgh-4	38	51	microscopy	microscopy	NOUN
cajgh-4	38	52	and	and	CCONJ
cajgh-4	38	53	quantitative	quantitative	ADJ
cajgh-4	38	54	immunofluorescence	immunofluorescence	NOUN
cajgh-4	38	55	microscopy	microscopy	NOUN
cajgh-4	38	56	studies	study	NOUN
cajgh-4	38	57	have	have	AUX
cajgh-4	38	58	demonstrated	demonstrate	VERB
cajgh-4	38	59	that	that	SCONJ
cajgh-4	38	60	aβ	aβ	NOUN
cajgh-4	38	61	oligomers	oligomer	NOUN
cajgh-4	38	62	induced	induce	VERB
cajgh-4	38	63	pselectin	pselectin	NOUN
cajgh-4	38	64	expression	expression	NOUN
cajgh-4	38	65	,	,	PUNCT
cajgh-4	38	66	increased	increase	VERB
cajgh-4	38	67	cell	cell	NOUN
cajgh-4	38	68	stiffness	stiffness	NOUN
cajgh-4	38	69	,	,	PUNCT
cajgh-4	38	70	decreased	decrease	VERB
cajgh-4	38	71	the	the	DET
cajgh-4	38	72	apparent	apparent	ADJ
cajgh-4	38	73	rupture	rupture	NOUN
cajgh-4	38	74	force	force	NOUN
cajgh-4	38	75	of	of	ADP
cajgh-4	38	76	selectin	selectin	ADJ
cajgh-4	38	77	-	-	PUNCT
cajgh-4	38	78	ligand	ligand	ADJ
cajgh-4	38	79	bonding	bonding	NOUN
cajgh-4	38	80	due	due	ADP
cajgh-4	38	81	to	to	ADP
cajgh-4	38	82	dissociation	dissociation	NOUN
cajgh-4	38	83	of	of	ADP
cajgh-4	38	84	adhesion	adhesion	NOUN
cajgh-4	38	85	between	between	ADP
cajgh-4	38	86	the	the	DET
cajgh-4	38	87	cytoskeleton	cytoskeleton	NOUN
cajgh-4	38	88	and	and	CCONJ
cajgh-4	38	89	the	the	DET
cajgh-4	38	90	bilayer	bilayer	NOUN
cajgh-4	38	91	membrane	membrane	NOUN
cajgh-4	38	92	,	,	PUNCT
cajgh-4	38	93	and	and	CCONJ
cajgh-4	38	94	,	,	PUNCT
cajgh-4	38	95	thus	thus	ADV
cajgh-4	38	96	,	,	PUNCT
cajgh-4	38	97	increased	increase	VERB
cajgh-4	38	98	probability	probability	NOUN
cajgh-4	38	99	of	of	ADP
cajgh-4	38	100	adhesion	adhesion	NOUN
cajgh-4	38	101	.	.	PUNCT
cajgh-4	39	1	91	91	NUM
cajgh-4	39	2	the	the	DET
cajgh-4	39	3	presence	presence	NOUN
cajgh-4	39	4	of	of	ADP
cajgh-4	39	5	the	the	DET
cajgh-4	39	6	tight	tight	ADJ
cajgh-4	39	7	junctions	junction	NOUN
cajgh-4	39	8	of	of	ADP
cajgh-4	39	9	high	high	ADJ
cajgh-4	39	10	electrical	electrical	ADJ
cajgh-4	39	11	resistance	resistance	NOUN
cajgh-4	39	12	and	and	CCONJ
cajgh-4	39	13	close	close	ADJ
cajgh-4	39	14	cell	cell	NOUN
cajgh-4	39	15	-	-	PUNCT
cajgh-4	39	16	cell	cell	NOUN
cajgh-4	39	17	contact	contact	NOUN
cajgh-4	39	18	are	be	AUX
cajgh-4	39	19	important	important	ADJ
cajgh-4	39	20	biomechanical	biomechanical	ADJ
cajgh-4	39	21	factors	factor	NOUN
cajgh-4	39	22	maintaining	maintain	VERB
cajgh-4	39	23	brain	brain	NOUN
cajgh-4	39	24	homeostasis	homeostasis	NOUN
cajgh-4	39	25	and	and	CCONJ
cajgh-4	39	26	bbb	bbb	NUM
cajgh-4	39	27	impermeability	impermeability	NOUN
cajgh-4	39	28	.	.	PUNCT
cajgh-4	40	1	tight	tight	ADJ
cajgh-4	40	2	junction	junction	NOUN
cajgh-4	40	3	is	be	AUX
cajgh-4	40	4	a	a	DET
cajgh-4	40	5	complex	complex	NOUN
cajgh-4	40	6	of	of	ADP
cajgh-4	40	7	transmembrane	transmembrane	ADJ
cajgh-4	40	8	proteins	protein	NOUN
cajgh-4	40	9	(	(	PUNCT
cajgh-4	40	10	occluding	occluding	NOUN
cajgh-4	40	11	,	,	PUNCT
cajgh-4	40	12	claudins	claudin	NOUN
cajgh-4	40	13	,	,	PUNCT
cajgh-4	40	14	junctional	junctional	ADJ
cajgh-4	40	15	molecule-1	molecule-1	NOUN
cajgh-4	40	16	)	)	PUNCT
cajgh-4	40	17	and	and	CCONJ
cajgh-4	40	18	submembrane	submembrane	NOUN
cajgh-4	40	19	molecules	molecule	NOUN
cajgh-4	40	20	connected	connect	VERB
cajgh-4	40	21	to	to	ADP
cajgh-4	40	22	actin	actin	NOUN
cajgh-4	40	23	network	network	NOUN
cajgh-4	40	24	.	.	PUNCT
cajgh-4	41	1	in	in	ADP
cajgh-4	41	2	fact	fact	NOUN
cajgh-4	41	3	,	,	PUNCT
cajgh-4	41	4	the	the	DET
cajgh-4	41	5	structure	structure	NOUN
cajgh-4	41	6	and	and	CCONJ
cajgh-4	41	7	functions	function	NOUN
cajgh-4	41	8	of	of	ADP
cajgh-4	41	9	the	the	DET
cajgh-4	41	10	tight	tight	ADJ
cajgh-4	41	11	junctions	junction	NOUN
cajgh-4	41	12	are	be	AUX
cajgh-4	41	13	strongly	strongly	ADV
cajgh-4	41	14	affected	affect	VERB
cajgh-4	41	15	in	in	ADP
cajgh-4	41	16	the	the	DET
cajgh-4	41	17	cerebrovascular	cerebrovascular	ADJ
cajgh-4	41	18	cells	cell	NOUN
cajgh-4	41	19	of	of	ADP
cajgh-4	41	20	ad	ad	NOUN
cajgh-4	41	21	patients.92	patients.92	NOUN
cajgh-4	41	22	in	in	ADP
cajgh-4	41	23	an	an	DET
cajgh-4	41	24	animal	animal	NOUN
cajgh-4	41	25	model	model	NOUN
cajgh-4	41	26	of	of	ADP
cajgh-4	41	27	ad	ad	NOUN
cajgh-4	41	28	,	,	PUNCT
cajgh-4	41	29	a	a	DET
cajgh-4	41	30	cholesterol	cholesterol	NOUN
cajgh-4	41	31	-	-	PUNCT
cajgh-4	41	32	enriched	enrich	VERB
cajgh-4	41	33	diet	diet	NOUN
cajgh-4	41	34	down	down	ADV
cajgh-4	41	35	-	-	PUNCT
cajgh-4	41	36	regulated	regulate	VERB
cajgh-4	41	37	the	the	DET
cajgh-4	41	38	expression	expression	NOUN
cajgh-4	41	39	of	of	ADP
cajgh-4	41	40	the	the	DET
cajgh-4	41	41	occluding	occluding	NOUN
cajgh-4	41	42	and	and	CCONJ
cajgh-4	41	43	zo-1	zo-1	NUM
cajgh-4	41	44	,	,	PUNCT
cajgh-4	41	45	which	which	PRON
cajgh-4	41	46	was	be	AUX
cajgh-4	41	47	strongly	strongly	ADV
cajgh-4	41	48	correlated	correlate	VERB
cajgh-4	41	49	with	with	ADP
cajgh-4	41	50	the	the	DET
cajgh-4	41	51	elevated	elevated	ADJ
cajgh-4	41	52	level	level	NOUN
cajgh-4	41	53	of	of	ADP
cajgh-4	41	54	the	the	DET
cajgh-4	41	55	bbb	bbb	PROPN
cajgh-4	41	56	leakage.93	leakage.93	PROPN
cajgh-4	41	57	in	in	ADP
cajgh-4	41	58	-	-	PUNCT
cajgh-4	41	59	vitro	vitro	NOUN
cajgh-4	41	60	,	,	PUNCT
cajgh-4	41	61	treatment	treatment	NOUN
cajgh-4	41	62	of	of	ADP
cajgh-4	41	63	primary	primary	ADJ
cajgh-4	41	64	rat	rat	NOUN
cajgh-4	41	65	cecs	cec	NOUN
cajgh-4	41	66	with	with	ADP
cajgh-4	41	67	aβ1	aβ1	NOUN
cajgh-4	41	68	-	-	PUNCT
cajgh-4	41	69	42	42	NUM
cajgh-4	41	70	for	for	ADP
cajgh-4	41	71	3	3	NUM
cajgh-4	41	72	days	day	NOUN
cajgh-4	41	73	altered	alter	VERB
cajgh-4	41	74	expression	expression	NOUN
cajgh-4	41	75	of	of	ADP
cajgh-4	41	76	occluding	occlude	VERB
cajgh-4	41	77	and	and	CCONJ
cajgh-4	41	78	claudin-1	claudin-1	PROPN
cajgh-4	41	79	,	,	PUNCT
cajgh-4	41	80	caused	cause	VERB
cajgh-4	41	81	relocation	relocation	NOUN
cajgh-4	41	82	of	of	ADP
cajgh-4	41	83	plasma	plasma	NOUN
cajgh-4	41	84	membrane	membrane	NOUN
cajgh-4	41	85	subunits	subunit	NOUN
cajgh-4	41	86	of	of	ADP
cajgh-4	41	87	claudin-5	claudin-5	PROPN
cajgh-4	41	88	and	and	CCONJ
cajgh-4	41	89	zo-2	zo-2	NUM
cajgh-4	41	90	to	to	ADP
cajgh-4	41	91	the	the	DET
cajgh-4	41	92	cytoplasm	cytoplasm	NOUN
cajgh-4	41	93	.	.	PUNCT
cajgh-4	42	1	at	at	ADP
cajgh-4	42	2	the	the	DET
cajgh-4	42	3	same	same	ADJ
cajgh-4	42	4	time	time	NOUN
cajgh-4	42	5	,	,	PUNCT
cajgh-4	42	6	the	the	DET
cajgh-4	42	7	cytoplasmic	cytoplasmic	ADJ
cajgh-4	42	8	zo-1	zo-1	NOUN
cajgh-4	42	9	and	and	CCONJ
cajgh-4	42	10	zo-2	zo-2	NUM
cajgh-4	42	11	where	where	SCONJ
cajgh-4	42	12	evenly	evenly	ADV
cajgh-4	42	13	distributed	distribute	VERB
cajgh-4	42	14	along	along	ADP
cajgh-4	42	15	the	the	DET
cajgh-4	42	16	plasma	plasma	NOUN
cajgh-4	42	17	membrane	membrane	NOUN
cajgh-4	42	18	at	at	ADP
cajgh-4	42	19	the	the	DET
cajgh-4	42	20	points	point	NOUN
cajgh-4	42	21	of	of	ADP
cajgh-4	42	22	the	the	DET
cajgh-4	42	23	cell	cell	NOUN
cajgh-4	42	24	-	-	PUNCT
cajgh-4	42	25	cell	cell	NOUN
cajgh-4	42	26	contacts.94	contacts.94	NOUN
cajgh-4	42	27	apolipoprotein	apolipoprotein	ADJ
cajgh-4	42	28	e4	e4	PROPN
cajgh-4	42	29	(	(	PUNCT
cajgh-4	42	30	apoe4	apoe4	PROPN
cajgh-4	42	31	)	)	PUNCT
cajgh-4	42	32	,	,	PUNCT
cajgh-4	42	33	a	a	DET
cajgh-4	42	34	major	major	ADJ
cajgh-4	42	35	risk	risk	NOUN
cajgh-4	42	36	factor	factor	NOUN
cajgh-4	42	37	for	for	ADP
cajgh-4	42	38	ad	ad	NOUN
cajgh-4	42	39	,	,	PUNCT
cajgh-4	42	40	has	have	AUX
cajgh-4	42	41	been	be	AUX
cajgh-4	42	42	shown	show	VERB
cajgh-4	42	43	to	to	PART
cajgh-4	42	44	be	be	AUX
cajgh-4	42	45	involved	involve	VERB
cajgh-4	42	46	in	in	ADP
cajgh-4	42	47	tight	tight	ADJ
cajgh-4	42	48	junction	junction	NOUN
cajgh-4	42	49	alteration	alteration	NOUN
cajgh-4	42	50	as	as	SCONJ
cajgh-4	42	51	well.95	well.95	NOUN
cajgh-4	42	52	it	it	PRON
cajgh-4	42	53	has	have	AUX
cajgh-4	42	54	been	be	AUX
cajgh-4	42	55	shown	show	VERB
cajgh-4	42	56	that	that	SCONJ
cajgh-4	42	57	mice	mouse	NOUN
cajgh-4	42	58	deficient	deficient	ADJ
cajgh-4	42	59	in	in	ADP
cajgh-4	42	60	apoe	apoe	NOUN
cajgh-4	42	61	have	have	AUX
cajgh-4	42	62	expressed	express	VERB
cajgh-4	42	63	bbb	bbb	NUM
cajgh-4	42	64	leakage	leakage	NOUN
cajgh-4	42	65	.	.	PUNCT
cajgh-4	43	1	in	in	ADP
cajgh-4	43	2	-	-	PUNCT
cajgh-4	43	3	vitro	vitro	X
cajgh-4	43	4	study	study	NOUN
cajgh-4	43	5	has	have	AUX
cajgh-4	43	6	demonstrated	demonstrate	VERB
cajgh-4	43	7	that	that	SCONJ
cajgh-4	43	8	the	the	DET
cajgh-4	43	9	barrier	barrier	NOUN
cajgh-4	43	10	functions	function	NOUN
cajgh-4	43	11	of	of	ADP
cajgh-4	43	12	tight	tight	ADJ
cajgh-4	43	13	junctions	junction	NOUN
cajgh-4	43	14	was	be	AUX
cajgh-4	43	15	impaired	impair	VERB
cajgh-4	43	16	when	when	SCONJ
cajgh-4	43	17	the	the	DET
cajgh-4	43	18	cecs	cec	NOUN
cajgh-4	43	19	were	be	AUX
cajgh-4	43	20	reconstituted	reconstitute	VERB
cajgh-4	43	21	with	with	ADP
cajgh-4	43	22	primary	primary	ADJ
cajgh-4	43	23	astrocytes	astrocyte	NOUN
cajgh-4	43	24	from	from	ADP
cajgh-4	43	25	apoe4	apoe4	ADJ
cajgh-4	43	26	-	-	PUNCT
cajgh-4	43	27	knock	knock	NOUN
cajgh-4	43	28	-	-	PUNCT
cajgh-4	43	29	in	in	ADP
cajgh-4	43	30	mice	mouse	NOUN
cajgh-4	43	31	.	.	PUNCT
cajgh-4	44	1	in	in	ADP
cajgh-4	44	2	particular	particular	ADJ
cajgh-4	44	3	,	,	PUNCT
cajgh-4	44	4	the	the	DET
cajgh-4	44	5	phosphorylation	phosphorylation	NOUN
cajgh-4	44	6	of	of	ADP
cajgh-4	44	7	occludin	occludin	NOUN
cajgh-4	44	8	and	and	CCONJ
cajgh-4	44	9	the	the	DET
cajgh-4	44	10	activation	activation	NOUN
cajgh-4	44	11	of	of	ADP
cajgh-4	44	12	protein	protein	NOUN
cajgh-4	44	13	kinase	kinase	NOUN
cajgh-4	44	14	c	c	PROPN
cajgh-4	44	15	(	(	PUNCT
cajgh-4	44	16	pkc)η	pkc)η	PROPN
cajgh-4	44	17	in	in	ADP
cajgh-4	44	18	cecs	cec	NOUN
cajgh-4	44	19	were	be	AUX
cajgh-4	44	20	attenuated	attenuate	VERB
cajgh-4	44	21	.	.	PUNCT
cajgh-4	45	1	these	these	DET
cajgh-4	45	2	findings	finding	NOUN
cajgh-4	45	3	suggest	suggest	VERB
cajgh-4	45	4	that	that	SCONJ
cajgh-4	45	5	the	the	DET
cajgh-4	45	6	effects	effect	NOUN
cajgh-4	45	7	of	of	ADP
cajgh-4	45	8	aβ	aβ	NOUN
cajgh-4	45	9	on	on	ADP
cajgh-4	45	10	actin	actin	NOUN
cajgh-4	45	11	and	and	CCONJ
cajgh-4	45	12	tight	tight	ADJ
cajgh-4	45	13	junction	junction	NOUN
cajgh-4	45	14	protein	protein	NOUN
cajgh-4	45	15	complexes	complex	NOUN
cajgh-4	45	16	,	,	PUNCT
cajgh-4	45	17	as	as	ADV
cajgh-4	45	18	well	well	ADV
cajgh-4	45	19	as	as	ADP
cajgh-4	45	20	vascular	vascular	ADJ
cajgh-4	45	21	risk	risk	NOUN
cajgh-4	45	22	factors	factor	NOUN
cajgh-4	45	23	cause	cause	VERB
cajgh-4	45	24	the	the	DET
cajgh-4	45	25	alteration	alteration	NOUN
cajgh-4	45	26	of	of	ADP
cajgh-4	45	27	endothelial	endothelial	ADJ
cajgh-4	45	28	layer	layer	NOUN
cajgh-4	45	29	integrity	integrity	NOUN
cajgh-4	45	30	and	and	CCONJ
cajgh-4	45	31	contribute	contribute	VERB
cajgh-4	45	32	to	to	ADP
cajgh-4	45	33	the	the	DET
cajgh-4	45	34	enhanced	enhanced	ADJ
cajgh-4	45	35	transmigration	transmigration	NOUN
cajgh-4	45	36	of	of	ADP
cajgh-4	45	37	monocytes	monocyte	NOUN
cajgh-4	45	38	across	across	ADP
cajgh-4	45	39	the	the	DET
cajgh-4	45	40	bbb	bbb	PROPN
cajgh-4	45	41	.	.	PUNCT
cajgh-4	46	1	thus	thus	ADV
cajgh-4	46	2	,	,	PUNCT
cajgh-4	46	3	studying	study	VERB
cajgh-4	46	4	the	the	DET
cajgh-4	46	5	aβ	aβ	NOUN
cajgh-4	46	6	-	-	PUNCT
cajgh-4	46	7	mediated	mediate	VERB
cajgh-4	46	8	alterations	alteration	NOUN
cajgh-4	46	9	in	in	ADP
cajgh-4	46	10	endothelial	endothelial	ADJ
cajgh-4	46	11	adhesion	adhesion	NOUN
cajgh-4	46	12	and	and	CCONJ
cajgh-4	46	13	bbb	bbb	NOUN
cajgh-4	46	14	permeability	permeability	NOUN
cajgh-4	46	15	would	would	AUX
cajgh-4	46	16	provide	provide	VERB
cajgh-4	46	17	insights	insight	NOUN
cajgh-4	46	18	into	into	ADP
cajgh-4	46	19	the	the	DET
cajgh-4	46	20	mechanism	mechanism	NOUN
cajgh-4	46	21	of	of	ADP
cajgh-4	46	22	bbb	bbb	PROPN
cajgh-4	46	23	dysfunction	dysfunction	NOUN
cajgh-4	46	24	and	and	CCONJ
cajgh-4	46	25	may	may	AUX
cajgh-4	46	26	provide	provide	VERB
cajgh-4	46	27	information	information	NOUN
cajgh-4	46	28	for	for	ADP
cajgh-4	46	29	developing	develop	VERB
cajgh-4	46	30	new	new	ADJ
cajgh-4	46	31	targeted	target	VERB
cajgh-4	46	32	drug	drug	NOUN
cajgh-4	46	33	delivery	delivery	NOUN
cajgh-4	46	34	vehicles96	vehicles96	NOUN
cajgh-4	46	35	for	for	ADP
cajgh-4	46	36	the	the	DET
cajgh-4	46	37	ad	ad	NOUN
cajgh-4	46	38	brain	brain	NOUN
cajgh-4	46	39	.	.	PUNCT
cajgh-4	47	1	conclusion	conclusion	NOUN
cajgh-4	47	2	chronic	chronic	VERB
cajgh-4	47	3	neurovascular	neurovascular	ADJ
cajgh-4	47	4	dysfunctions	dysfunction	NOUN
cajgh-4	47	5	and	and	CCONJ
cajgh-4	47	6	degeneration	degeneration	NOUN
cajgh-4	47	7	of	of	ADP
cajgh-4	47	8	endothelium	endothelium	NOUN
cajgh-4	47	9	are	be	AUX
cajgh-4	47	10	observed	observe	VERB
cajgh-4	47	11	in	in	ADP
cajgh-4	47	12	the	the	DET
cajgh-4	47	13	all	all	DET
cajgh-4	47	14	stages	stage	NOUN
cajgh-4	47	15	of	of	ADP
cajgh-4	47	16	ad	ad	NOUN
cajgh-4	47	17	.	.	PUNCT
cajgh-4	48	1	numerous	numerous	ADJ
cajgh-4	48	2	in	in	ADP
cajgh-4	48	3	vivo	vivo	NOUN
cajgh-4	48	4	and	and	CCONJ
cajgh-4	48	5	in	in	ADP
cajgh-4	48	6	vitro	vitro	X
cajgh-4	48	7	studies	study	NOUN
cajgh-4	48	8	have	have	AUX
cajgh-4	48	9	demonstrated	demonstrate	VERB
cajgh-4	48	10	that	that	PRON
cajgh-4	48	11	vascular	vascular	ADJ
cajgh-4	48	12	deposition	deposition	NOUN
cajgh-4	48	13	of	of	ADP
cajgh-4	48	14	amyloid	amyloid	NOUN
cajgh-4	48	15	beta	beta	NOUN
cajgh-4	48	16	peptide	peptide	NOUN
cajgh-4	48	17	induces	induce	VERB
cajgh-4	48	18	oxidative	oxidative	ADJ
cajgh-4	48	19	stress	stress	NOUN
cajgh-4	48	20	in	in	ADP
cajgh-4	48	21	cerebral	cerebral	ADJ
cajgh-4	48	22	vasculature	vasculature	NOUN
cajgh-4	48	23	,	,	PUNCT
cajgh-4	48	24	triggers	trigger	VERB
cajgh-4	48	25	inflammatory	inflammatory	ADJ
cajgh-4	48	26	processes	process	NOUN
cajgh-4	48	27	and	and	CCONJ
cajgh-4	48	28	apoptosis	apoptosis	NOUN
cajgh-4	48	29	,	,	PUNCT
cajgh-4	48	30	promotes	promote	VERB
cajgh-4	48	31	expression	expression	NOUN
cajgh-4	48	32	of	of	ADP
cajgh-4	48	33	adhesion	adhesion	NOUN
cajgh-4	48	34	molecules	molecule	NOUN
cajgh-4	48	35	,	,	PUNCT
cajgh-4	48	36	affects	affect	VERB
cajgh-4	48	37	tight	tight	ADJ
cajgh-4	48	38	junctions	junction	NOUN
cajgh-4	48	39	,	,	PUNCT
cajgh-4	48	40	changes	change	VERB
cajgh-4	48	41	mechanical	mechanical	ADJ
cajgh-4	48	42	properties	property	NOUN
cajgh-4	48	43	of	of	ADP
cajgh-4	48	44	the	the	DET
cajgh-4	48	45	cecs	cec	NOUN
cajgh-4	48	46	membranes	membrane	NOUN
cajgh-4	48	47	,	,	PUNCT
cajgh-4	48	48	and	and	CCONJ
cajgh-4	48	49	enhances	enhance	VERB
cajgh-4	48	50	transmigration	transmigration	NOUN
cajgh-4	48	51	of	of	ADP
cajgh-4	48	52	immune	immune	ADJ
cajgh-4	48	53	cells	cell	NOUN
cajgh-4	48	54	across	across	ADP
cajgh-4	48	55	bbb	bbb	PROPN
cajgh-4	48	56	.	.	PUNCT
cajgh-4	49	1	continuous	continuous	ADJ
cajgh-4	49	2	degeneration	degeneration	NOUN
cajgh-4	49	3	of	of	ADP
cajgh-4	49	4	cecs	cec	NOUN
cajgh-4	49	5	impairs	impair	VERB
cajgh-4	49	6	bbb	bbb	NOUN
cajgh-4	49	7	permeability	permeability	NOUN
cajgh-4	49	8	and	and	CCONJ
cajgh-4	49	9	leads	lead	VERB
cajgh-4	49	10	to	to	ADP
cajgh-4	49	11	leakage	leakage	NOUN
cajgh-4	49	12	of	of	ADP
cajgh-4	49	13	blood	blood	NOUN
cajgh-4	49	14	cells	cell	NOUN
cajgh-4	49	15	,	,	PUNCT
cajgh-4	49	16	plasma	plasma	NOUN
cajgh-4	49	17	components	component	NOUN
cajgh-4	49	18	and	and	CCONJ
cajgh-4	49	19	neurotoxic	neurotoxic	ADJ
cajgh-4	49	20	substances	substance	NOUN
cajgh-4	49	21	into	into	ADP
cajgh-4	49	22	the	the	DET
cajgh-4	49	23	brain	brain	NOUN
cajgh-4	49	24	parenchyma	parenchyma	NOUN
cajgh-4	49	25	.	.	PUNCT
cajgh-4	50	1	breakdown	breakdown	NOUN
cajgh-4	50	2	of	of	ADP
cajgh-4	50	3	blood	blood	NOUN
cajgh-4	50	4	brain	brain	NOUN
cajgh-4	50	5	barrier	barrier	NOUN
cajgh-4	50	6	functions	function	NOUN
cajgh-4	50	7	drives	drive	VERB
cajgh-4	50	8	the	the	DET
cajgh-4	50	9	disease	disease	NOUN
cajgh-4	50	10	development	development	NOUN
cajgh-4	50	11	towards	towards	ADP
cajgh-4	50	12	exacerbation	exacerbation	NOUN
cajgh-4	50	13	of	of	ADP
cajgh-4	50	14	the	the	DET
cajgh-4	50	15	oxidative	oxidative	ADJ
cajgh-4	50	16	and	and	CCONJ
cajgh-4	50	17	inflammatory	inflammatory	ADJ
cajgh-4	50	18	conditions	condition	NOUN
cajgh-4	50	19	characteristic	characteristic	ADJ
cajgh-4	50	20	of	of	ADP
cajgh-4	50	21	the	the	DET
cajgh-4	50	22	ad	ad	NOUN
cajgh-4	50	23	brain	brain	NOUN
cajgh-4	50	24	and	and	CCONJ
cajgh-4	50	25	contributes	contribute	VERB
cajgh-4	50	26	to	to	ADP
cajgh-4	50	27	further	further	ADJ
cajgh-4	50	28	progression	progression	NOUN
cajgh-4	50	29	of	of	ADP
cajgh-4	50	30	the	the	DET
cajgh-4	50	31	disease	disease	NOUN
cajgh-4	50	32	.	.	PUNCT
cajgh-4	51	1	understanding	understand	VERB
cajgh-4	51	2	the	the	DET
cajgh-4	51	3	precise	precise	ADJ
cajgh-4	51	4	molecular	molecular	ADJ
cajgh-4	51	5	mechanisms	mechanism	NOUN
cajgh-4	51	6	underlying	underlie	VERB
cajgh-4	51	7	ab	ab	PROPN
cajgh-4	51	8	-	-	PUNCT
cajgh-4	51	9	mediated	mediate	VERB
cajgh-4	51	10	oxidative	oxidative	ADJ
cajgh-4	51	11	stress	stress	NOUN
cajgh-4	51	12	in	in	ADP
cajgh-4	51	13	cecs	cec	NOUN
cajgh-4	51	14	,	,	PUNCT
cajgh-4	51	15	the	the	DET
cajgh-4	51	16	effects	effect	NOUN
cajgh-4	51	17	of	of	ADP
cajgh-4	51	18	aβ42	aβ42	PROPN
cajgh-4	51	19	on	on	ADP
cajgh-4	51	20	the	the	DET
cajgh-4	51	21	bbb	bbb	NOUN
cajgh-4	51	22	adhesion	adhesion	NOUN
cajgh-4	51	23	and	and	CCONJ
cajgh-4	51	24	permeability	permeability	NOUN
cajgh-4	51	25	should	should	AUX
cajgh-4	51	26	prove	prove	VERB
cajgh-4	51	27	to	to	PART
cajgh-4	51	28	provide	provide	VERB
cajgh-4	51	29	new	new	ADJ
cajgh-4	51	30	insights	insight	NOUN
cajgh-4	51	31	into	into	ADP
cajgh-4	51	32	the	the	DET
cajgh-4	51	33	development	development	NOUN
cajgh-4	51	34	of	of	ADP
cajgh-4	51	35	preventive	preventive	ADJ
cajgh-4	51	36	and	and	CCONJ
cajgh-4	51	37	treatment	treatment	NOUN
cajgh-4	51	38	strategies	strategy	NOUN
cajgh-4	51	39	for	for	ADP
cajgh-4	51	40	ad	ad	NOUN
cajgh-4	51	41	.	.	PUNCT
cajgh-4	52	1	references	reference	NOUN
cajgh-4	52	2	1	1	NUM
cajgh-4	52	3	.	.	PUNCT
cajgh-4	53	1	kandel	kandel	PROPN
cajgh-4	53	2	er	er	INTJ
cajgh-4	53	3	,	,	PUNCT
cajgh-4	53	4	schwartz	schwartz	PROPN
cajgh-4	53	5	jh	jh	PROPN
cajgh-4	53	6	,	,	PUNCT
cajgh-4	53	7	jessel	jessel	PROPN
cajgh-4	53	8	tm	tm	PROPN
cajgh-4	53	9	,	,	PUNCT
cajgh-4	53	10	editors	editor	NOUN
cajgh-4	53	11	.	.	PUNCT
cajgh-4	54	1	principles	principle	NOUN
cajgh-4	54	2	of	of	ADP
cajgh-4	54	3	neural	neural	ADJ
cajgh-4	54	4	science	science	NOUN
cajgh-4	54	5	4ed2000	4ed2000	PROPN
cajgh-4	54	6	.	.	PUNCT
cajgh-4	55	1	2	2	NUM
cajgh-4	55	2	.	.	X
cajgh-4	55	3	hardy	hardy	PROPN
cajgh-4	55	4	j	j	PROPN
cajgh-4	55	5	,	,	PUNCT
cajgh-4	55	6	selkoe	selkoe	PROPN
cajgh-4	55	7	dj	dj	NOUN
cajgh-4	55	8	.	.	PUNCT
cajgh-4	56	1	the	the	DET
cajgh-4	56	2	amyloid	amyloid	NOUN
cajgh-4	56	3	hypothesis	hypothesis	NOUN
cajgh-4	56	4	of	of	ADP
cajgh-4	56	5	alzheimer	alzheimer	PROPN
cajgh-4	56	6	's	's	PART
cajgh-4	56	7	disease	disease	NOUN
cajgh-4	56	8	:	:	PUNCT
cajgh-4	56	9	progress	progress	NOUN
cajgh-4	56	10	and	and	CCONJ
cajgh-4	56	11	problems	problem	NOUN
cajgh-4	56	12	on	on	ADP
cajgh-4	56	13	the	the	DET
cajgh-4	56	14	road	road	NOUN
cajgh-4	56	15	to	to	ADP
cajgh-4	56	16	therapeutics	therapeutic	NOUN
cajgh-4	56	17	.	.	PUNCT
cajgh-4	57	1	science	science	NOUN
cajgh-4	57	2	.	.	PUNCT
cajgh-4	58	1	2002;297(5580):353	2002;297(5580):353	NUM
cajgh-4	58	2	-	-	SYM
cajgh-4	58	3	6	6	NUM
cajgh-4	58	4	.	.	NOUN
cajgh-4	59	1	3	3	NUM
cajgh-4	59	2	.	.	X
cajgh-4	59	3	vassar	vassar	PROPN
cajgh-4	59	4	r.	r.	PROPN
cajgh-4	59	5	bace1	bace1	PROPN
cajgh-4	59	6	:	:	PUNCT
cajgh-4	59	7	the	the	DET
cajgh-4	59	8	beta	beta	NOUN
cajgh-4	59	9	-	-	PUNCT
cajgh-4	59	10	secretase	secretase	NOUN
cajgh-4	59	11	enzyme	enzyme	NOUN
cajgh-4	59	12	in	in	ADP
cajgh-4	59	13	alzheimer	alzheimer	PROPN
cajgh-4	59	14	's	's	PART
cajgh-4	59	15	disease	disease	NOUN
cajgh-4	59	16	.	.	PUNCT
cajgh-4	60	1	j	j	PROPN
cajgh-4	60	2	mol	mol	PROPN
cajgh-4	60	3	neurosci	neurosci	PROPN
cajgh-4	60	4	.	.	PUNCT
cajgh-4	61	1	2004;23(1	2004;23(1	X
cajgh-4	61	2	-	-	PUNCT
cajgh-4	61	3	2):105	2):105	NUM
cajgh-4	61	4	-	-	PUNCT
cajgh-4	61	5	14	14	NUM
cajgh-4	61	6	.	.	PUNCT
cajgh-4	62	1	epub	epub	NOUN
cajgh-4	62	2	2004/05/06	2004/05/06	NOUN
cajgh-4	62	3	.	.	PUNCT
cajgh-4	63	1	4	4	NUM
cajgh-4	63	2	.	.	X
cajgh-4	63	3	bernstein	bernstein	PROPN
cajgh-4	63	4	sl	sl	PROPN
cajgh-4	63	5	,	,	PUNCT
cajgh-4	63	6	wyttenbach	wyttenbach	VERB
cajgh-4	63	7	t	t	PROPN
cajgh-4	63	8	,	,	PUNCT
cajgh-4	63	9	baumketner	baumketner	X
cajgh-4	63	10	a	a	X
cajgh-4	63	11	,	,	PUNCT
cajgh-4	63	12	shea	shea	PROPN
cajgh-4	63	13	j	j	PROPN
cajgh-4	63	14	-	-	PUNCT
cajgh-4	63	15	e	e	PROPN
cajgh-4	63	16	,	,	PUNCT
cajgh-4	63	17	bitan	bitan	PROPN
cajgh-4	63	18	g	g	NOUN
cajgh-4	63	19	,	,	PUNCT
cajgh-4	63	20	teplow	teplow	PROPN
cajgh-4	63	21	db	db	PROPN
cajgh-4	63	22	,	,	PUNCT
cajgh-4	63	23	et	et	PROPN
cajgh-4	63	24	al	al	PROPN
cajgh-4	63	25	.	.	PUNCT
cajgh-4	63	26	amyloid	amyloid	PROPN
cajgh-4	63	27	оі	оі	NOUN
cajgh-4	63	28	-	-	PUNCT
cajgh-4	63	29	protein	protein	NOUN
cajgh-4	63	30	:	:	PUNCT
cajgh-4	63	31	вђ‰	вђ‰	ADJ
cajgh-4	63	32	monomer	monomer	NOUN
cajgh-4	63	33	structure	structure	NOUN
cajgh-4	63	34	and	and	CCONJ
cajgh-4	63	35	early	early	ADJ
cajgh-4	63	36	aggregation	aggregation	NOUN
cajgh-4	63	37	states	state	NOUN
cajgh-4	63	38	of	of	ADP
cajgh-4	63	39	aоі42	aоі42	PROPN
cajgh-4	63	40	and	and	CCONJ
cajgh-4	63	41	its	its	PRON
cajgh-4	63	42	pro19	pro19	NOUN
cajgh-4	63	43	alloform	alloform	NOUN
cajgh-4	63	44	.	.	PUNCT
cajgh-4	64	1	journal	journal	PROPN
cajgh-4	64	2	of	of	ADP
cajgh-4	64	3	the	the	DET
cajgh-4	64	4	american	american	PROPN
cajgh-4	64	5	chemical	chemical	PROPN
cajgh-4	64	6	society	society	NOUN
cajgh-4	64	7	.	.	PUNCT
cajgh-4	65	1	2005;127(7):2075	2005;127(7):2075	NUM
cajgh-4	65	2	-	-	SYM
cajgh-4	65	3	84	84	NUM
cajgh-4	65	4	.	.	PUNCT
cajgh-4	66	1	5	5	NUM
cajgh-4	66	2	.	.	X
cajgh-4	66	3	walsh	walsh	PROPN
cajgh-4	66	4	dm	dm	PROPN
cajgh-4	66	5	,	,	PUNCT
cajgh-4	66	6	selkoe	selkoe	PROPN
cajgh-4	66	7	dj	dj	NOUN
cajgh-4	66	8	.	.	PUNCT
cajgh-4	67	1	aβ	aβ	PRON
cajgh-4	67	2	oligomers	oligomer	NOUN
cajgh-4	67	3	–	–	PUNCT
cajgh-4	67	4	a	a	DET
cajgh-4	67	5	decade	decade	NOUN
cajgh-4	67	6	of	of	ADP
cajgh-4	67	7	discovery	discovery	NOUN
cajgh-4	67	8	.	.	PUNCT
cajgh-4	68	1	journal	journal	PROPN
cajgh-4	68	2	of	of	ADP
cajgh-4	68	3	neurochemistry	neurochemistry	NOUN
cajgh-4	68	4	.	.	PUNCT
cajgh-4	69	1	2007;101(5):1172	2007;101(5):1172	NUM
cajgh-4	69	2	-	-	SYM
cajgh-4	69	3	84	84	NUM
cajgh-4	69	4	.	.	PUNCT
cajgh-4	70	1	6	6	NUM
cajgh-4	70	2	.	.	X
cajgh-4	71	1	dahlgren	dahlgren	PROPN
cajgh-4	71	2	kn	kn	PROPN
cajgh-4	71	3	,	,	PUNCT
cajgh-4	71	4	manelli	manelli	PROPN
cajgh-4	71	5	am	am	PROPN
cajgh-4	71	6	,	,	PUNCT
cajgh-4	71	7	stine	stine	PROPN
cajgh-4	71	8	wb	wb	PROPN
cajgh-4	71	9	,	,	PUNCT
cajgh-4	71	10	baker	baker	PROPN
cajgh-4	71	11	lk	lk	PROPN
cajgh-4	71	12	,	,	PUNCT
cajgh-4	71	13	krafft	krafft	PROPN
cajgh-4	71	14	ga	ga	PROPN
cajgh-4	71	15	,	,	PUNCT
cajgh-4	71	16	ladu	ladu	PROPN
cajgh-4	71	17	mj	mj	PROPN
cajgh-4	71	18	.	.	PROPN
cajgh-4	71	19	oligomeric	oligomeric	ADJ
cajgh-4	71	20	and	and	CCONJ
cajgh-4	71	21	fibrillar	fibrillar	ADJ
cajgh-4	71	22	species	specie	NOUN
cajgh-4	71	23	of	of	ADP
cajgh-4	71	24	amyloid	amyloid	NOUN
cajgh-4	71	25	-	-	PUNCT
cajgh-4	71	26	оі	оі	NOUN
cajgh-4	71	27	peptides	peptide	NOUN
cajgh-4	71	28	differentially	differentially	ADV
cajgh-4	71	29	affect	affect	VERB
cajgh-4	71	30	neuronal	neuronal	ADJ
cajgh-4	71	31	viability	viability	NOUN
cajgh-4	71	32	.	.	PUNCT
cajgh-4	72	1	journal	journal	NOUN
cajgh-4	72	2	of	of	ADP
cajgh-4	72	3	biological	biological	ADJ
cajgh-4	72	4	chemistry	chemistry	NOUN
cajgh-4	72	5	.	.	PUNCT
cajgh-4	73	1	2002;277(35):32046	2002;277(35):32046	NUM
cajgh-4	73	2	-	-	SYM
cajgh-4	73	3	53	53	NUM
cajgh-4	73	4	.	.	PUNCT
cajgh-4	74	1	7	7	X
cajgh-4	74	2	.	.	PUNCT
cajgh-4	75	1	resende	resende	NOUN
cajgh-4	75	2	r	r	NOUN
cajgh-4	75	3	,	,	PUNCT
cajgh-4	75	4	ferreiro	ferreiro	NOUN
cajgh-4	75	5	e	e	PROPN
cajgh-4	75	6	,	,	PUNCT
cajgh-4	75	7	pereira	pereira	PROPN
cajgh-4	75	8	c	c	PROPN
cajgh-4	75	9	,	,	PUNCT
cajgh-4	75	10	resende	resende	PROPN
cajgh-4	75	11	de	de	PROPN
cajgh-4	75	12	oliveira	oliveira	PROPN
cajgh-4	75	13	c.	c.	PROPN
cajgh-4	75	14	neurotoxic	neurotoxic	ADJ
cajgh-4	75	15	effect	effect	NOUN
cajgh-4	75	16	of	of	ADP
cajgh-4	75	17	oligomeric	oligomeric	ADJ
cajgh-4	75	18	and	and	CCONJ
cajgh-4	75	19	fibrillar	fibrillar	ADJ
cajgh-4	75	20	species	specie	NOUN
cajgh-4	75	21	of	of	ADP
cajgh-4	75	22	amyloid	amyloid	NOUN
cajgh-4	75	23	-	-	PUNCT
cajgh-4	75	24	beta	beta	NOUN
cajgh-4	75	25	peptide	peptide	NOUN
cajgh-4	75	26	1	1	NUM
cajgh-4	75	27	-	-	SYM
cajgh-4	75	28	42	42	NUM
cajgh-4	75	29	:	:	PUNCT
cajgh-4	75	30	involvement	involvement	NOUN
cajgh-4	75	31	of	of	ADP
cajgh-4	75	32	endoplasmic	endoplasmic	ADJ
cajgh-4	75	33	reticulum	reticulum	NOUN
cajgh-4	75	34	calcium	calcium	NOUN
cajgh-4	75	35	release	release	NOUN
cajgh-4	75	36	in	in	ADP
cajgh-4	75	37	oligomer	oligomer	ADV
cajgh-4	75	38	-	-	PUNCT
cajgh-4	75	39	induced	induce	VERB
cajgh-4	75	40	cell	cell	NOUN
cajgh-4	75	41	death	death	NOUN
cajgh-4	75	42	.	.	PUNCT
cajgh-4	76	1	neuroscience	neuroscience	NOUN
cajgh-4	76	2	.	.	PUNCT
cajgh-4	77	1	2008;155(3):725	2008;155(3):725	NUM
cajgh-4	77	2	-	-	SYM
cajgh-4	77	3	37	37	NUM
cajgh-4	77	4	.	.	NOUN
cajgh-4	78	1	8	8	NUM
cajgh-4	78	2	.	.	PUNCT
cajgh-4	79	1	cleary	cleary	PROPN
cajgh-4	79	2	jp	jp	PROPN
cajgh-4	79	3	,	,	PUNCT
cajgh-4	79	4	walsh	walsh	PROPN
cajgh-4	79	5	dm	dm	PROPN
cajgh-4	79	6	,	,	PUNCT
cajgh-4	79	7	hofmeister	hofmeister	PROPN
cajgh-4	79	8	jj	jj	PROPN
cajgh-4	79	9	,	,	PUNCT
cajgh-4	79	10	shankar	shankar	PROPN
cajgh-4	79	11	gm	gm	PROPN
cajgh-4	79	12	,	,	PUNCT
cajgh-4	79	13	kuskowski	kuskowski	VERB
cajgh-4	79	14	ma	ma	PROPN
cajgh-4	79	15	,	,	PUNCT
cajgh-4	79	16	selkoe	selkoe	ADJ
cajgh-4	79	17	dj	dj	PROPN
cajgh-4	79	18	,	,	PUNCT
cajgh-4	79	19	et	et	PROPN
cajgh-4	79	20	al	al	PROPN
cajgh-4	79	21	.	.	PROPN
cajgh-4	79	22	natural	natural	ADJ
cajgh-4	79	23	oligomers	oligomer	NOUN
cajgh-4	79	24	of	of	ADP
cajgh-4	79	25	the	the	DET
cajgh-4	79	26	amyloid-[beta	amyloid-[beta	PROPN
cajgh-4	79	27	]	]	X
cajgh-4	79	28	protein	protein	NOUN
cajgh-4	79	29	specifically	specifically	ADV
cajgh-4	79	30	disrupt	disrupt	VERB
cajgh-4	79	31	cognitive	cognitive	ADJ
cajgh-4	79	32	function	function	NOUN
cajgh-4	79	33	.	.	PUNCT
cajgh-4	80	1	nat	nat	PROPN
cajgh-4	80	2	neurosci	neurosci	PROPN
cajgh-4	80	3	.	.	PUNCT
cajgh-4	81	1	2005;8(1):79	2005;8(1):79	NUM
cajgh-4	81	2	-	-	SYM
cajgh-4	81	3	84	84	NUM
cajgh-4	81	4	.	.	PUNCT
cajgh-4	82	1	9	9	X
cajgh-4	82	2	.	.	X
cajgh-4	82	3	zlokovic	zlokovic	PROPN
cajgh-4	82	4	bv	bv	PROPN
cajgh-4	82	5	.	.	PROPN
cajgh-4	82	6	neurovascular	neurovascular	PROPN
cajgh-4	82	7	pathways	pathway	NOUN
cajgh-4	82	8	to	to	ADP
cajgh-4	82	9	neurodegeneration	neurodegeneration	NOUN
cajgh-4	82	10	in	in	ADP
cajgh-4	82	11	alzheimer	alzheimer	PROPN
cajgh-4	82	12	's	's	PART
cajgh-4	82	13	disease	disease	NOUN
cajgh-4	82	14	and	and	CCONJ
cajgh-4	82	15	other	other	ADJ
cajgh-4	82	16	disorders	disorder	NOUN
cajgh-4	82	17	.	.	PUNCT
cajgh-4	83	1	nat	nat	PROPN
cajgh-4	83	2	rev	rev	PROPN
cajgh-4	83	3	neurosci	neurosci	PROPN
cajgh-4	83	4	.	.	PUNCT
cajgh-4	83	5	2011;12(12):723	2011;12(12):723	PROPN
cajgh-4	83	6	-	-	SYM
cajgh-4	83	7	38	38	NUM
cajgh-4	83	8	.	.	PUNCT
cajgh-4	84	1	10	10	NUM
cajgh-4	84	2	.	.	PUNCT
cajgh-4	84	3	stanimirovic	stanimirovic	PROPN
cajgh-4	84	4	db	db	PROPN
cajgh-4	84	5	,	,	PUNCT
cajgh-4	84	6	friedman	friedman	PROPN
cajgh-4	84	7	a.	a.	NOUN
cajgh-4	84	8	pathophysiology	pathophysiology	NOUN
cajgh-4	84	9	of	of	ADP
cajgh-4	84	10	the	the	DET
cajgh-4	84	11	neurovascular	neurovascular	ADJ
cajgh-4	84	12	unit	unit	NOUN
cajgh-4	84	13	:	:	PUNCT
cajgh-4	84	14	disease	disease	NOUN
cajgh-4	84	15	cause	cause	NOUN
cajgh-4	84	16	or	or	CCONJ
cajgh-4	84	17	consequence[quest	consequence[quest	NOUN
cajgh-4	84	18	]	]	X
cajgh-4	84	19	.	.	PUNCT
cajgh-4	85	1	j	j	PROPN
cajgh-4	85	2	cereb	cereb	PROPN
cajgh-4	85	3	blood	blood	NOUN
cajgh-4	85	4	flow	flow	NOUN
cajgh-4	85	5	metab	metab	NOUN
cajgh-4	85	6	.	.	PUNCT
cajgh-4	86	1	2011;32(7):1207	2011;32(7):1207	NOUN
cajgh-4	86	2	-	-	SYM
cajgh-4	86	3	21	21	NUM
cajgh-4	86	4	.	.	PUNCT
cajgh-4	87	1	11	11	NUM
cajgh-4	87	2	.	.	PUNCT
cajgh-4	88	1	iadecola	iadecola	PROPN
cajgh-4	88	2	c.	c.	PROPN
cajgh-4	89	1	the	the	DET
cajgh-4	89	2	overlap	overlap	NOUN
cajgh-4	89	3	between	between	ADP
cajgh-4	89	4	neurodegenerative	neurodegenerative	ADJ
cajgh-4	89	5	and	and	CCONJ
cajgh-4	89	6	vascular	vascular	ADJ
cajgh-4	89	7	factors	factor	NOUN
cajgh-4	89	8	in	in	ADP
cajgh-4	89	9	the	the	DET
cajgh-4	89	10	pathogenesis	pathogenesis	NOUN
cajgh-4	89	11	of	of	ADP
cajgh-4	89	12	dementia	dementia	NOUN
cajgh-4	89	13	.	.	PUNCT
cajgh-4	90	1	acta	acta	PROPN
cajgh-4	90	2	neuropathol	neuropathol	PROPN
cajgh-4	90	3	2010	2010	NUM
cajgh-4	90	4	120(3):287	120(3):287	NUM
cajgh-4	90	5	-	-	SYM
cajgh-4	90	6	96	96	NUM
cajgh-4	90	7	.	.	PUNCT
cajgh-4	90	8	12	12	NUM
cajgh-4	90	9	.	.	PUNCT
cajgh-4	91	1	liu	liu	PROPN
cajgh-4	91	2	r	r	PROPN
cajgh-4	91	3	,	,	PUNCT
cajgh-4	91	4	zhang	zhang	PROPN
cajgh-4	91	5	t	t	PROPN
cajgh-4	91	6	-	-	PUNCT
cajgh-4	91	7	t	t	PROPN
cajgh-4	91	8	,	,	PUNCT
cajgh-4	91	9	wu	wu	PROPN
cajgh-4	91	10	c	c	PROPN
cajgh-4	91	11	-	-	PUNCT
cajgh-4	91	12	x	x	NOUN
cajgh-4	91	13	,	,	PUNCT
cajgh-4	91	14	lan	lan	PROPN
cajgh-4	91	15	x	x	X
cajgh-4	91	16	,	,	PUNCT
cajgh-4	91	17	du	du	PROPN
cajgh-4	91	18	g	g	PROPN
cajgh-4	91	19	-	-	PUNCT
cajgh-4	91	20	h.	h.	NOUN
cajgh-4	91	21	targeting	target	VERB
cajgh-4	91	22	the	the	DET
cajgh-4	91	23	neurovascular	neurovascular	ADJ
cajgh-4	91	24	unit	unit	NOUN
cajgh-4	91	25	:	:	PUNCT
cajgh-4	91	26	development	development	NOUN
cajgh-4	91	27	of	of	ADP
cajgh-4	91	28	a	a	DET
cajgh-4	91	29	new	new	ADJ
cajgh-4	91	30	model	model	NOUN
cajgh-4	91	31	and	and	CCONJ
cajgh-4	91	32	consideration	consideration	NOUN
cajgh-4	91	33	for	for	ADP
cajgh-4	91	34	novel	novel	ADJ
cajgh-4	91	35	strategy	strategy	NOUN
cajgh-4	91	36	for	for	ADP
cajgh-4	91	37	alzheimer	alzheimer	PROPN
cajgh-4	91	38	's	's	PART
cajgh-4	91	39	disease	disease	NOUN
cajgh-4	91	40	.	.	PUNCT
cajgh-4	92	1	brain	brain	NOUN
cajgh-4	92	2	research	research	NOUN
cajgh-4	92	3	bulletin	bulletin	NOUN
cajgh-4	92	4	.	.	PUNCT
cajgh-4	93	1	2011;86(1вђ“2):13	2011;86(1вђ“2):13	NUM
cajgh-4	93	2	-	-	SYM
cajgh-4	93	3	21	21	NUM
cajgh-4	93	4	.	.	PUNCT
cajgh-4	94	1	13	13	NUM
cajgh-4	94	2	.	.	PUNCT
cajgh-4	95	1	salmina	salmina	PROPN
cajgh-4	95	2	a	a	PROPN
cajgh-4	95	3	,	,	PUNCT
cajgh-4	95	4	inzhutova	inzhutova	VERB
cajgh-4	95	5	a	a	PRON
cajgh-4	95	6	,	,	PUNCT
cajgh-4	95	7	malinovskaya	malinovskaya	NOUN
cajgh-4	95	8	n	n	CCONJ
cajgh-4	95	9	,	,	PUNCT
cajgh-4	95	10	petrova	petrova	PROPN
cajgh-4	95	11	m.	m.	NOUN
cajgh-4	95	12	endothelial	endothelial	ADJ
cajgh-4	95	13	dysfunction	dysfunction	NOUN
cajgh-4	95	14	and	and	CCONJ
cajgh-4	95	15	repair	repair	NOUN
cajgh-4	95	16	in	in	ADP
cajgh-4	95	17	alzheimer	alzheimer	ADJ
cajgh-4	95	18	-	-	PUNCT
cajgh-4	95	19	type	type	NOUN
cajgh-4	95	20	neurodegeneration	neurodegeneration	NOUN
cajgh-4	95	21	:	:	PUNCT
cajgh-4	95	22	neuronal	neuronal	ADJ
cajgh-4	95	23	and	and	CCONJ
cajgh-4	95	24	glial	glial	ADJ
cajgh-4	95	25	control	control	NOUN
cajgh-4	95	26	.	.	PUNCT
cajgh-4	96	1	j	j	PROPN
cajgh-4	96	2	alzheimers	alzheimers	PROPN
cajgh-4	96	3	dis	dis	PROPN
cajgh-4	96	4	.	.	PUNCT
cajgh-4	97	1	2010;22(1):17	2010;22(1):17	NUM
cajgh-4	97	2	-	-	SYM
cajgh-4	97	3	36	36	NUM
cajgh-4	97	4	.	.	PUNCT
cajgh-4	98	1	14	14	NUM
cajgh-4	98	2	.	.	PUNCT
cajgh-4	99	1	ruitenberg	ruitenberg	PROPN
cajgh-4	99	2	a	a	PRON
cajgh-4	99	3	,	,	PUNCT
cajgh-4	99	4	den	den	PROPN
cajgh-4	99	5	heijer	heijer	PROPN
cajgh-4	99	6	t	t	PROPN
cajgh-4	99	7	,	,	PUNCT
cajgh-4	99	8	bakker	bakker	PROPN
cajgh-4	99	9	sl	sl	PROPN
cajgh-4	99	10	,	,	PUNCT
cajgh-4	99	11	van	van	PROPN
cajgh-4	99	12	swieten	swieten	PROPN
cajgh-4	99	13	jc	jc	PROPN
cajgh-4	99	14	,	,	PUNCT
cajgh-4	99	15	koudstaal	koudstaal	PROPN
cajgh-4	99	16	pj	pj	PROPN
cajgh-4	99	17	,	,	PUNCT
cajgh-4	99	18	hofman	hofman	PROPN
cajgh-4	99	19	a	a	PRON
cajgh-4	99	20	,	,	PUNCT
cajgh-4	99	21	et	et	PROPN
cajgh-4	99	22	al	al	PROPN
cajgh-4	99	23	.	.	PROPN
cajgh-4	99	24	cerebral	cerebral	ADJ
cajgh-4	99	25	hypoperfusion	hypoperfusion	NOUN
cajgh-4	99	26	and	and	CCONJ
cajgh-4	99	27	clinical	clinical	ADJ
cajgh-4	99	28	onset	onset	NOUN
cajgh-4	99	29	of	of	ADP
cajgh-4	99	30	dementia	dementia	NOUN
cajgh-4	99	31	:	:	PUNCT
cajgh-4	99	32	the	the	DET
cajgh-4	99	33	rotterdam	rotterdam	PROPN
cajgh-4	99	34	study	study	NOUN
cajgh-4	99	35	.	.	PUNCT
cajgh-4	100	1	ann	ann	PROPN
cajgh-4	100	2	neurol	neurol	PROPN
cajgh-4	100	3	.	.	PUNCT
cajgh-4	101	1	2005;57(6):789	2005;57(6):789	NUM
cajgh-4	101	2	-	-	SYM
cajgh-4	101	3	94	94	NUM
cajgh-4	101	4	.	.	PUNCT
cajgh-4	102	1	epub	epub	NOUN
cajgh-4	102	2	2005/06/02	2005/06/02	NUM
cajgh-4	102	3	.	.	PUNCT
cajgh-4	103	1	15	15	NUM
cajgh-4	103	2	.	.	PUNCT
cajgh-4	103	3	zlokovic	zlokovic	PROPN
cajgh-4	103	4	bv	bv	PROPN
cajgh-4	103	5	.	.	PROPN
cajgh-4	103	6	new	new	ADJ
cajgh-4	103	7	therapeutic	therapeutic	ADJ
cajgh-4	103	8	targets	target	NOUN
cajgh-4	103	9	in	in	ADP
cajgh-4	103	10	the	the	DET
cajgh-4	103	11	neurovascular	neurovascular	ADJ
cajgh-4	103	12	pathway	pathway	NOUN
cajgh-4	103	13	in	in	ADP
cajgh-4	103	14	alzheimer	alzheimer	PROPN
cajgh-4	103	15	's	's	PART
cajgh-4	103	16	disease	disease	NOUN
cajgh-4	103	17	.	.	PUNCT
cajgh-4	104	1	neurotherapeutics	neurotherapeutics	PROPN
cajgh-4	104	2	.	.	PUNCT
cajgh-4	105	1	2008;5(3):409	2008;5(3):409	NUM
cajgh-4	105	2	-	-	SYM
cajgh-4	105	3	14	14	NUM
cajgh-4	105	4	.	.	PUNCT
cajgh-4	106	1	epub	epub	NOUN
cajgh-4	106	2	2008/07/16	2008/07/16	NUM
cajgh-4	106	3	.	.	PUNCT
cajgh-4	107	1	16	16	NUM
cajgh-4	107	2	.	.	PUNCT
cajgh-4	108	1	bell	bell	PROPN
cajgh-4	108	2	r	r	PROPN
cajgh-4	108	3	,	,	PUNCT
cajgh-4	108	4	zlokovic	zlokovic	PROPN
cajgh-4	108	5	b.	b.	PROPN
cajgh-4	108	6	neurovascular	neurovascular	ADJ
cajgh-4	108	7	mechanisms	mechanism	NOUN
cajgh-4	108	8	and	and	CCONJ
cajgh-4	108	9	blood	blood	NOUN
cajgh-4	108	10	–	–	PUNCT
cajgh-4	108	11	brain	brain	NOUN
cajgh-4	108	12	barrier	barrier	NOUN
cajgh-4	108	13	disorder	disorder	NOUN
cajgh-4	108	14	in	in	ADP
cajgh-4	108	15	alzheimer	alzheimer	PROPN
cajgh-4	108	16	’s	’s	PART
cajgh-4	108	17	disease	disease	NOUN
cajgh-4	108	18	.	.	PUNCT
cajgh-4	109	1	acta	acta	PROPN
cajgh-4	109	2	neuropathologica	neuropathologica	PROPN
cajgh-4	109	3	.	.	PUNCT
cajgh-4	110	1	2009;118(1):103	2009;118(1):103	NUM
cajgh-4	110	2	-	-	SYM
cajgh-4	110	3	13	13	NUM
cajgh-4	110	4	.	.	PUNCT
cajgh-4	111	1	17	17	NUM
cajgh-4	111	2	.	.	PUNCT
cajgh-4	112	1	iadecola	iadecola	PROPN
cajgh-4	112	2	c.	c.	PROPN
cajgh-4	112	3	cerebrovascular	cerebrovascular	ADJ
cajgh-4	112	4	effects	effect	NOUN
cajgh-4	112	5	of	of	ADP
cajgh-4	112	6	amyloid	amyloid	NOUN
cajgh-4	112	7	-	-	PUNCT
cajgh-4	112	8	beta	beta	NOUN
cajgh-4	112	9	peptides	peptide	NOUN
cajgh-4	112	10	:	:	PUNCT
cajgh-4	112	11	mechanisms	mechanism	NOUN
cajgh-4	112	12	and	and	CCONJ
cajgh-4	112	13	implications	implication	NOUN
cajgh-4	112	14	for	for	ADP
cajgh-4	112	15	alzheimer	alzheimer	PROPN
cajgh-4	112	16	's	's	PART
cajgh-4	112	17	dementia	dementia	NOUN
cajgh-4	112	18	.	.	PUNCT
cajgh-4	113	1	cell	cell	NOUN
cajgh-4	113	2	mol	mol	ADP
cajgh-4	113	3	neurobiol	neurobiol	NOUN
cajgh-4	113	4	.	.	PUNCT
cajgh-4	114	1	2003;23(4	2003;23(4	X
cajgh-4	114	2	-	-	SYM
cajgh-4	114	3	5):681	5):681	NUM
cajgh-4	114	4	-	-	PUNCT
cajgh-4	114	5	9	9	NUM
cajgh-4	114	6	.	.	NOUN
cajgh-4	114	7	18	18	NUM
cajgh-4	114	8	.	.	X
cajgh-4	114	9	de	de	PROPN
cajgh-4	114	10	la	la	PROPN
cajgh-4	114	11	torre	torre	PROPN
cajgh-4	114	12	jc	jc	PROPN
cajgh-4	114	13	.	.	PUNCT
cajgh-4	115	1	how	how	SCONJ
cajgh-4	115	2	do	do	AUX
cajgh-4	115	3	heart	heart	NOUN
cajgh-4	115	4	disease	disease	NOUN
cajgh-4	115	5	and	and	CCONJ
cajgh-4	115	6	stroke	stroke	NOUN
cajgh-4	115	7	become	become	VERB
cajgh-4	115	8	risk	risk	NOUN
cajgh-4	115	9	factors	factor	NOUN
cajgh-4	115	10	for	for	ADP
cajgh-4	115	11	alzheimer	alzheimer	PROPN
cajgh-4	115	12	's	's	PART
cajgh-4	115	13	disease	disease	NOUN
cajgh-4	115	14	?	?	PUNCT
cajgh-4	116	1	neurological	neurological	ADJ
cajgh-4	116	2	research	research	NOUN
cajgh-4	116	3	.	.	PUNCT
cajgh-4	117	1	2006;28:637	2006;28:637	X
cajgh-4	117	2	-	-	SYM
cajgh-4	117	3	44	44	NUM
cajgh-4	117	4	.	.	PUNCT
cajgh-4	118	1	19	19	NUM
cajgh-4	118	2	.	.	PUNCT
cajgh-4	119	1	deane	deane	PROPN
cajgh-4	119	2	r	r	PROPN
cajgh-4	119	3	,	,	PUNCT
cajgh-4	119	4	zlokovic	zlokovic	PROPN
cajgh-4	119	5	bv	bv	PROPN
cajgh-4	119	6	.	.	PROPN
cajgh-4	119	7	role	role	NOUN
cajgh-4	119	8	of	of	ADP
cajgh-4	119	9	the	the	DET
cajgh-4	119	10	blood	blood	NOUN
cajgh-4	119	11	-	-	PUNCT
cajgh-4	119	12	brain	brain	NOUN
cajgh-4	119	13	barrier	barrier	NOUN
cajgh-4	119	14	in	in	ADP
cajgh-4	119	15	the	the	DET
cajgh-4	119	16	pathogenesis	pathogenesis	NOUN
cajgh-4	119	17	of	of	ADP
cajgh-4	119	18	alzheimers	alzheimers	PROPN
cajgh-4	119	19	disease	disease	NOUN
cajgh-4	119	20	.	.	PUNCT
cajgh-4	120	1	current	current	ADJ
cajgh-4	120	2	alzheimer	alzheimer	PROPN
cajgh-4	120	3	research	research	PROPN
cajgh-4	120	4	2007(4):191	2007(4):191	NUM
cajgh-4	120	5	-	-	SYM
cajgh-4	120	6	7	7	NUM
cajgh-4	120	7	.	.	NOUN
cajgh-4	120	8	20	20	NUM
cajgh-4	120	9	.	.	PUNCT
cajgh-4	121	1	girouard	girouard	PROPN
cajgh-4	121	2	h	h	PROPN
cajgh-4	121	3	,	,	PUNCT
cajgh-4	121	4	iadecola	iadecola	PROPN
cajgh-4	121	5	c.	c.	PROPN
cajgh-4	121	6	neurovascular	neurovascular	PROPN
cajgh-4	121	7	coupling	couple	VERB
cajgh-4	121	8	in	in	ADP
cajgh-4	121	9	the	the	DET
cajgh-4	121	10	normal	normal	ADJ
cajgh-4	121	11	brain	brain	NOUN
cajgh-4	121	12	and	and	CCONJ
cajgh-4	121	13	in	in	ADP
cajgh-4	121	14	hypertension	hypertension	NOUN
cajgh-4	121	15	,	,	PUNCT
cajgh-4	121	16	stroke	stroke	NOUN
cajgh-4	121	17	,	,	PUNCT
cajgh-4	121	18	and	and	CCONJ
cajgh-4	121	19	alzheimer	alzheimer	PROPN
cajgh-4	121	20	disease	disease	NOUN
cajgh-4	121	21	.	.	PUNCT
cajgh-4	122	1	j	j	PROPN
cajgh-4	122	2	appl	appl	PROPN
cajgh-4	122	3	physiol	physiol	PROPN
cajgh-4	122	4	.	.	PUNCT
cajgh-4	123	1	2006;100(1):328	2006;100(1):328	NUM
cajgh-4	123	2	-	-	SYM
cajgh-4	123	3	35	35	NUM
cajgh-4	123	4	.	.	PUNCT
cajgh-4	124	1	21	21	NUM
cajgh-4	124	2	.	.	PUNCT
cajgh-4	125	1	hofman	hofman	PROPN
cajgh-4	125	2	a	a	PRON
cajgh-4	125	3	,	,	PUNCT
cajgh-4	125	4	ott	ott	PROPN
cajgh-4	125	5	a	a	NOUN
cajgh-4	125	6	,	,	PUNCT
cajgh-4	125	7	breteler	breteler	PROPN
cajgh-4	125	8	mmb	mmb	PROPN
cajgh-4	125	9	,	,	PUNCT
cajgh-4	125	10	bots	bot	NOUN
cajgh-4	125	11	ml	ml	NOUN
cajgh-4	125	12	,	,	PUNCT
cajgh-4	125	13	slooter	slooter	PROPN
cajgh-4	125	14	ajc	ajc	PROPN
cajgh-4	125	15	,	,	PUNCT
cajgh-4	125	16	van	van	PROPN
cajgh-4	125	17	harskamp	harskamp	PROPN
cajgh-4	125	18	f	f	PROPN
cajgh-4	125	19	,	,	PUNCT
cajgh-4	125	20	et	et	PROPN
cajgh-4	125	21	al	al	PROPN
cajgh-4	125	22	.	.	PUNCT
cajgh-4	125	23	atherosclerosis	atherosclerosis	NOUN
cajgh-4	125	24	,	,	PUNCT
cajgh-4	125	25	apolipoprotein	apolipoprotein	ADJ
cajgh-4	125	26	e	e	NOUN
cajgh-4	125	27	,	,	PUNCT
cajgh-4	125	28	and	and	CCONJ
cajgh-4	125	29	prevalence	prevalence	NOUN
cajgh-4	125	30	of	of	ADP
cajgh-4	125	31	dementia	dementia	NOUN
cajgh-4	125	32	and	and	CCONJ
cajgh-4	125	33	alzheimer	alzheimer	PROPN
cajgh-4	125	34	's	's	PART
cajgh-4	125	35	disease	disease	NOUN
cajgh-4	125	36	in	in	ADP
cajgh-4	125	37	the	the	DET
cajgh-4	125	38	rotterdam	rotterdam	PROPN
cajgh-4	125	39	study	study	NOUN
cajgh-4	125	40	.	.	PUNCT
cajgh-4	126	1	the	the	DET
cajgh-4	126	2	lancet	lancet	NOUN
cajgh-4	126	3	.	.	PUNCT
cajgh-4	127	1	1997;349(9046):151	1997;349(9046):151	NUM
cajgh-4	127	2	-	-	SYM
cajgh-4	127	3	4	4	NUM
cajgh-4	127	4	.	.	NOUN
cajgh-4	127	5	22	22	NUM
cajgh-4	127	6	.	.	PUNCT
cajgh-4	128	1	bradbury	bradbury	PROPN
cajgh-4	128	2	mw	mw	PROPN
cajgh-4	128	3	.	.	PUNCT
cajgh-4	129	1	the	the	DET
cajgh-4	129	2	blood	blood	NOUN
cajgh-4	129	3	-	-	PUNCT
cajgh-4	129	4	brain	brain	NOUN
cajgh-4	129	5	barrier	barrier	NOUN
cajgh-4	129	6	.	.	PUNCT
cajgh-4	130	1	transport	transport	NOUN
cajgh-4	130	2	across	across	ADP
cajgh-4	130	3	the	the	DET
cajgh-4	130	4	cerebral	cerebral	ADJ
cajgh-4	130	5	endothelium	endothelium	NOUN
cajgh-4	130	6	.	.	PUNCT
cajgh-4	131	1	circ	circ	PROPN
cajgh-4	131	2	res	re	NOUN
cajgh-4	131	3	.	.	PUNCT
cajgh-4	132	1	1985;57(2):213	1985;57(2):213	NUM
cajgh-4	132	2	-	-	SYM
cajgh-4	132	3	22	22	NUM
cajgh-4	132	4	.	.	PUNCT
cajgh-4	132	5	23	23	NUM
cajgh-4	132	6	.	.	X
cajgh-4	133	1	scheibel	scheibel	NOUN
cajgh-4	133	2	a	a	PRON
cajgh-4	133	3	,	,	PUNCT
cajgh-4	133	4	duong	duong	PROPN
cajgh-4	133	5	t	t	PROPN
cajgh-4	133	6	,	,	PUNCT
cajgh-4	133	7	jacobs	jacobs	PROPN
cajgh-4	133	8	r.	r.	PROPN
cajgh-4	133	9	alzheimer	alzheimer	PROPN
cajgh-4	133	10	's	's	PART
cajgh-4	133	11	disease	disease	NOUN
cajgh-4	133	12	as	as	ADP
cajgh-4	133	13	a	a	DET
cajgh-4	133	14	capillary	capillary	ADJ
cajgh-4	133	15	dementia	dementia	NOUN
cajgh-4	133	16	.	.	PUNCT
cajgh-4	134	1	ann	ann	PROPN
cajgh-4	134	2	med	med	PROPN
cajgh-4	134	3	.	.	PUNCT
cajgh-4	135	1	1989;21(2):103	1989;21(2):103	NUM
cajgh-4	135	2	-	-	SYM
cajgh-4	135	3	7	7	NUM
cajgh-4	135	4	.	.	NUM
cajgh-4	135	5	24	24	NUM
cajgh-4	135	6	.	.	PUNCT
cajgh-4	135	7	de	de	PROPN
cajgh-4	135	8	la	la	PROPN
cajgh-4	135	9	torre	torre	PROPN
cajgh-4	135	10	jc	jc	PROPN
cajgh-4	135	11	.	.	PROPN
cajgh-4	135	12	is	be	AUX
cajgh-4	135	13	alzheimer	alzheimer	PROPN
cajgh-4	135	14	's	's	PART
cajgh-4	135	15	disease	disease	NOUN
cajgh-4	135	16	a	a	DET
cajgh-4	135	17	neurodegenerative	neurodegenerative	ADJ
cajgh-4	135	18	or	or	CCONJ
cajgh-4	135	19	a	a	DET
cajgh-4	135	20	vascular	vascular	ADJ
cajgh-4	135	21	disorder	disorder	NOUN
cajgh-4	135	22	?	?	PUNCT
cajgh-4	136	1	data	datum	NOUN
cajgh-4	136	2	,	,	PUNCT
cajgh-4	136	3	dogma	dogma	NOUN
cajgh-4	136	4	,	,	PUNCT
cajgh-4	136	5	and	and	CCONJ
cajgh-4	136	6	dialectics	dialectic	NOUN
cajgh-4	136	7	.	.	PUNCT
cajgh-4	137	1	the	the	DET
cajgh-4	137	2	lancet	lancet	PROPN
cajgh-4	137	3	neurology	neurology	NOUN
cajgh-4	137	4	.	.	PUNCT
cajgh-4	138	1	2004;3(3):184	2004;3(3):184	NUM
cajgh-4	138	2	-	-	SYM
cajgh-4	138	3	90	90	NUM
cajgh-4	138	4	.	.	PUNCT
cajgh-4	139	1	25	25	NUM
cajgh-4	139	2	.	.	PUNCT
cajgh-4	139	3	borroni	borroni	PROPN
cajgh-4	139	4	b	b	PROPN
cajgh-4	139	5	,	,	PUNCT
cajgh-4	139	6	akkawi	akkawi	NOUN
cajgh-4	139	7	n	n	CCONJ
cajgh-4	139	8	,	,	PUNCT
cajgh-4	139	9	martini	martini	NOUN
cajgh-4	139	10	g	g	NOUN
cajgh-4	139	11	,	,	PUNCT
cajgh-4	139	12	colciaghi	colciaghi	PROPN
cajgh-4	139	13	f	f	PROPN
cajgh-4	139	14	,	,	PUNCT
cajgh-4	139	15	prometti	prometti	NOUN
cajgh-4	139	16	p	p	NOUN
cajgh-4	139	17	,	,	PUNCT
cajgh-4	139	18	rozzini	rozzini	PROPN
cajgh-4	139	19	l	l	NOUN
cajgh-4	139	20	,	,	PUNCT
cajgh-4	139	21	et	et	PROPN
cajgh-4	140	1	al	al	PROPN
cajgh-4	140	2	.	.	PUNCT
cajgh-4	140	3	microvascular	microvascular	ADJ
cajgh-4	140	4	damage	damage	NOUN
cajgh-4	140	5	and	and	CCONJ
cajgh-4	140	6	platelet	platelet	NOUN
cajgh-4	140	7	abnormalities	abnormality	NOUN
cajgh-4	140	8	in	in	ADP
cajgh-4	140	9	early	early	ADJ
cajgh-4	140	10	alzheimer	alzheimer	PROPN
cajgh-4	140	11	's	's	PART
cajgh-4	140	12	disease	disease	NOUN
cajgh-4	140	13	.	.	PUNCT
cajgh-4	141	1	journal	journal	NOUN
cajgh-4	141	2	of	of	ADP
cajgh-4	141	3	the	the	DET
cajgh-4	141	4	neurological	neurological	ADJ
cajgh-4	141	5	sciences	science	NOUN
cajgh-4	141	6	.	.	PUNCT
cajgh-4	142	1	2002;203	2002;203	NUM
cajgh-4	142	2	-	-	PUNCT
cajgh-4	142	3	204:189	204:189	NUM
cajgh-4	142	4	-	-	PUNCT
cajgh-4	142	5	93	93	NUM
cajgh-4	142	6	.	.	PUNCT
cajgh-4	143	1	26	26	NUM
cajgh-4	143	2	.	.	PUNCT
cajgh-4	144	1	farkas	farkas	PROPN
cajgh-4	144	2	e	e	PROPN
cajgh-4	144	3	,	,	PUNCT
cajgh-4	144	4	luiten	luiten	PROPN
cajgh-4	144	5	pgm	pgm	PROPN
cajgh-4	144	6	.	.	PUNCT
cajgh-4	144	7	cerebral	cerebral	ADJ
cajgh-4	144	8	microvascular	microvascular	ADJ
cajgh-4	144	9	pathology	pathology	NOUN
cajgh-4	144	10	in	in	ADP
cajgh-4	144	11	aging	aging	NOUN
cajgh-4	144	12	and	and	CCONJ
cajgh-4	144	13	alzheimer	alzheimer	NOUN
cajgh-4	144	14	's	's	PART
cajgh-4	144	15	disease	disease	NOUN
cajgh-4	144	16	.	.	PUNCT
cajgh-4	145	1	progress	progress	NOUN
cajgh-4	145	2	in	in	ADP
cajgh-4	145	3	neurobiology	neurobiology	NOUN
cajgh-4	145	4	.	.	PUNCT
cajgh-4	146	1	2001;64(6):575	2001;64(6):575	NUM
cajgh-4	146	2	-	-	PUNCT
cajgh-4	146	3	611	611	NUM
cajgh-4	146	4	.	.	PUNCT
cajgh-4	147	1	27	27	NUM
cajgh-4	147	2	.	.	PUNCT
cajgh-4	148	1	luc	luc	PROPN
cajgh-4	148	2	b	b	PROPN
cajgh-4	148	3	,	,	PUNCT
cajgh-4	148	4	patrick	patrick	PROPN
cajgh-4	148	5	r	r	PROPN
cajgh-4	148	6	hof	hof	PROPN
cajgh-4	148	7	,	,	PUNCT
cajgh-4	148	8	andrй	andrй	PROPN
cajgh-4	148	9	d.	d.	PROPN
cajgh-4	148	10	brain	brain	NOUN
cajgh-4	148	11	microvascular	microvascular	NOUN
cajgh-4	148	12	changes	change	NOUN
cajgh-4	148	13	in	in	ADP
cajgh-4	148	14	alzheimer	alzheimer	PROPN
cajgh-4	148	15	's	's	PART
cajgh-4	148	16	disease	disease	NOUN
cajgh-4	148	17	and	and	CCONJ
cajgh-4	148	18	other	other	ADJ
cajgh-4	148	19	dementiasa	dementiasa	PROPN
cajgh-4	148	20	.	.	PUNCT
cajgh-4	149	1	annals	annal	NOUN
cajgh-4	149	2	of	of	ADP
cajgh-4	149	3	the	the	DET
cajgh-4	149	4	new	new	PROPN
cajgh-4	149	5	york	york	PROPN
cajgh-4	149	6	academy	academy	PROPN
cajgh-4	149	7	of	of	ADP
cajgh-4	149	8	sciences	sciences	PROPN
cajgh-4	149	9	.	.	PUNCT
cajgh-4	150	1	1997;826(cerebrovascular	1997;826(cerebrovascular	NUM
cajgh-4	150	2	pathology	pathology	NOUN
cajgh-4	150	3	in	in	ADP
cajgh-4	150	4	alzheimer	alzheimer	PROPN
cajgh-4	150	5	's	's	PART
cajgh-4	150	6	disease):7	disease):7	ADJ
cajgh-4	150	7	-	-	NOUN
cajgh-4	150	8	24	24	NUM
cajgh-4	150	9	.	.	PUNCT
cajgh-4	151	1	28	28	NUM
cajgh-4	151	2	.	.	PUNCT
cajgh-4	152	1	berzin	berzin	PROPN
cajgh-4	152	2	tm	tm	PROPN
cajgh-4	152	3	,	,	PUNCT
cajgh-4	152	4	zipser	zipser	PROPN
cajgh-4	152	5	bd	bd	PROPN
cajgh-4	152	6	,	,	PUNCT
cajgh-4	152	7	rafii	rafii	ADJ
cajgh-4	152	8	ms	ms	PROPN
cajgh-4	152	9	,	,	PUNCT
cajgh-4	152	10	kuo	kuo	PROPN
cajgh-4	152	11	--	--	PUNCT
cajgh-4	152	12	leblanc	leblanc	PROPN
cajgh-4	152	13	v	v	PROPN
cajgh-4	152	14	,	,	PUNCT
cajgh-4	152	15	yancopoulos	yancopoulos	PROPN
cajgh-4	152	16	gd	gd	NOUN
cajgh-4	152	17	,	,	PUNCT
cajgh-4	152	18	glass	glass	NOUN
cajgh-4	152	19	dj	dj	PROPN
cajgh-4	152	20	,	,	PUNCT
cajgh-4	152	21	et	et	PROPN
cajgh-4	152	22	al	al	PROPN
cajgh-4	152	23	.	.	PUNCT
cajgh-4	153	1	agrin	agrin	NOUN
cajgh-4	153	2	and	and	CCONJ
cajgh-4	153	3	microvascular	microvascular	ADJ
cajgh-4	153	4	damage	damage	NOUN
cajgh-4	153	5	in	in	ADP
cajgh-4	153	6	alzheimer	alzheimer	PROPN
cajgh-4	153	7	's	's	PART
cajgh-4	153	8	disease	disease	NOUN
cajgh-4	153	9	.	.	PUNCT
cajgh-4	154	1	neurobiology	neurobiology	NOUN
cajgh-4	154	2	of	of	ADP
cajgh-4	154	3	aging	aging	NOUN
cajgh-4	154	4	.	.	PUNCT
cajgh-4	155	1	2000;21(2):349	2000;21(2):349	PROPN
cajgh-4	155	2	-	-	PUNCT
cajgh-4	155	3	55	55	NUM
cajgh-4	155	4	.	.	PUNCT
cajgh-4	156	1	29	29	NUM
cajgh-4	156	2	.	.	PUNCT
cajgh-4	156	3	bailey	bailey	PROPN
cajgh-4	156	4	tl	tl	PROPN
cajgh-4	156	5	,	,	PUNCT
cajgh-4	156	6	rivara	rivara	PROPN
cajgh-4	156	7	cb	cb	PROPN
cajgh-4	156	8	,	,	PUNCT
cajgh-4	156	9	rocher	rocher	PROPN
cajgh-4	156	10	ab	ab	PROPN
cajgh-4	156	11	,	,	PUNCT
cajgh-4	156	12	hof	hof	PROPN
cajgh-4	156	13	pr	pr	PROPN
cajgh-4	156	14	.	.	PUNCT
cajgh-4	157	1	the	the	DET
cajgh-4	157	2	nature	nature	NOUN
cajgh-4	157	3	and	and	CCONJ
cajgh-4	157	4	effects	effect	NOUN
cajgh-4	157	5	of	of	ADP
cajgh-4	157	6	cortical	cortical	ADJ
cajgh-4	157	7	microvascular	microvascular	ADJ
cajgh-4	157	8	pathology	pathology	NOUN
cajgh-4	157	9	in	in	ADP
cajgh-4	157	10	aging	aging	NOUN
cajgh-4	157	11	and	and	CCONJ
cajgh-4	157	12	alzheimer	alzheimer	NOUN
cajgh-4	157	13	's	's	PART
cajgh-4	157	14	disease	disease	NOUN
cajgh-4	157	15	.	.	PUNCT
cajgh-4	158	1	neurological	neurological	ADJ
cajgh-4	158	2	research	research	NOUN
cajgh-4	158	3	.	.	PUNCT
cajgh-4	159	1	2004;26:573	2004;26:573	X
cajgh-4	159	2	-	-	SYM
cajgh-4	159	3	8	8	NUM
cajgh-4	159	4	.	.	NOUN
cajgh-4	159	5	30	30	NUM
cajgh-4	159	6	.	.	PUNCT
cajgh-4	160	1	kalaria	kalaria	PROPN
cajgh-4	160	2	rn	rn	PROPN
cajgh-4	160	3	,	,	PUNCT
cajgh-4	160	4	pax	pax	PROPN
cajgh-4	160	5	ab	ab	PROPN
cajgh-4	160	6	.	.	PROPN
cajgh-4	160	7	increased	increase	VERB
cajgh-4	160	8	collagen	collagen	NOUN
cajgh-4	160	9	content	content	NOUN
cajgh-4	160	10	of	of	ADP
cajgh-4	160	11	cerebral	cerebral	ADJ
cajgh-4	160	12	microvessels	microvessel	NOUN
cajgh-4	160	13	in	in	ADP
cajgh-4	160	14	alzheimer	alzheimer	PROPN
cajgh-4	160	15	's	's	PART
cajgh-4	160	16	disease	disease	NOUN
cajgh-4	160	17	.	.	PUNCT
cajgh-4	161	1	brain	brain	NOUN
cajgh-4	161	2	research	research	NOUN
cajgh-4	161	3	.	.	PUNCT
cajgh-4	162	1	1995;705(1	1995;705(1	X
cajgh-4	162	2	-	-	PUNCT
cajgh-4	162	3	2):349	2):349	PROPN
cajgh-4	162	4	-	-	PUNCT
cajgh-4	162	5	52	52	NUM
cajgh-4	162	6	.	.	PUNCT
cajgh-4	163	1	31	31	NUM
cajgh-4	163	2	.	.	PUNCT
cajgh-4	164	1	ervin	ervin	PROPN
cajgh-4	164	2	jf	jf	PROPN
cajgh-4	164	3	,	,	PUNCT
cajgh-4	164	4	pannell	pannell	VERB
cajgh-4	164	5	c	c	NOUN
cajgh-4	164	6	,	,	PUNCT
cajgh-4	164	7	szymanski	szymanski	PROPN
cajgh-4	164	8	m	m	PROPN
cajgh-4	164	9	,	,	PUNCT
cajgh-4	164	10	welsh	welsh	NOUN
cajgh-4	164	11	-	-	PUNCT
cajgh-4	164	12	bohmer	bohmer	PROPN
cajgh-4	164	13	k	k	PROPN
cajgh-4	164	14	,	,	PUNCT
cajgh-4	164	15	schmechel	schmechel	PROPN
cajgh-4	164	16	de	de	PROPN
cajgh-4	164	17	,	,	PUNCT
cajgh-4	164	18	hulette	hulette	PROPN
cajgh-4	164	19	cm	cm	PROPN
cajgh-4	164	20	.	.	PUNCT
cajgh-4	165	1	vascular	vascular	ADJ
cajgh-4	165	2	smooth	smooth	ADJ
cajgh-4	165	3	muscle	muscle	NOUN
cajgh-4	165	4	actin	actin	NOUN
cajgh-4	165	5	is	be	AUX
cajgh-4	165	6	reduced	reduce	VERB
cajgh-4	165	7	in	in	ADP
cajgh-4	165	8	alzheimer	alzheimer	PROPN
cajgh-4	165	9	disease	disease	PROPN
cajgh-4	165	10	brain	brain	NOUN
cajgh-4	165	11	:	:	PUNCT
cajgh-4	165	12	a	a	DET
cajgh-4	165	13	quantitative	quantitative	ADJ
cajgh-4	165	14	analysis	analysis	NOUN
cajgh-4	165	15	.	.	PUNCT
cajgh-4	166	1	journal	journal	PROPN
cajgh-4	166	2	of	of	ADP
cajgh-4	166	3	neuropathology	neuropathology	NOUN
cajgh-4	166	4	&	&	CCONJ
cajgh-4	166	5	experimental	experimental	ADJ
cajgh-4	166	6	neurology	neurology	NOUN
cajgh-4	166	7	.	.	PUNCT
cajgh-4	167	1	2004;63(7):735	2004;63(7):735	NUM
cajgh-4	167	2	-	-	SYM
cajgh-4	167	3	41	41	NUM
cajgh-4	167	4	.	.	PUNCT
cajgh-4	168	1	32	32	NUM
cajgh-4	168	2	.	.	PUNCT
cajgh-4	169	1	kalaria	kalaria	PROPN
cajgh-4	169	2	rn	rn	PROPN
cajgh-4	169	3	hp	hp	PROPN
cajgh-4	169	4	.	.	PROPN
cajgh-4	169	5	differential	differential	ADJ
cajgh-4	169	6	degeneration	degeneration	NOUN
cajgh-4	169	7	of	of	ADP
cajgh-4	169	8	the	the	DET
cajgh-4	169	9	cerebral	cerebral	ADJ
cajgh-4	169	10	microvasculature	microvasculature	NOUN
cajgh-4	169	11	in	in	ADP
cajgh-4	169	12	alzheimer	alzheimer	PROPN
cajgh-4	169	13	’s	’s	PART
cajgh-4	169	14	disease	disease	NOUN
cajgh-4	169	15	.	.	PUNCT
cajgh-4	170	1	neuroreport	neuroreport	NOUN
cajgh-4	170	2	.	.	PUNCT
cajgh-4	171	1	1995(6):477	1995(6):477	NUM
cajgh-4	171	2	-	-	SYM
cajgh-4	171	3	80	80	NUM
cajgh-4	171	4	.	.	PUNCT
cajgh-4	172	1	33	33	NUM
cajgh-4	172	2	.	.	PUNCT
cajgh-4	172	3	claudio	claudio	PROPN
cajgh-4	172	4	l.	l.	PROPN
cajgh-4	172	5	ultrastructural	ultrastructural	PROPN
cajgh-4	172	6	features	feature	NOUN
cajgh-4	172	7	of	of	ADP
cajgh-4	172	8	the	the	DET
cajgh-4	172	9	blood	blood	NOUN
cajgh-4	172	10	-	-	PUNCT
cajgh-4	172	11	brain	brain	NOUN
cajgh-4	172	12	barrier	barrier	NOUN
cajgh-4	172	13	in	in	ADP
cajgh-4	172	14	biopsy	biopsy	ADJ
cajgh-4	172	15	tissue	tissue	NOUN
cajgh-4	172	16	from	from	ADP
cajgh-4	172	17	alzheimer	alzheimer	PROPN
cajgh-4	172	18	's	's	PART
cajgh-4	172	19	disease	disease	NOUN
cajgh-4	172	20	patients	patient	NOUN
cajgh-4	172	21	.	.	PUNCT
cajgh-4	173	1	acta	acta	PROPN
cajgh-4	173	2	neuropathologica	neuropathologica	PROPN
cajgh-4	173	3	1996	1996	NUM
cajgh-4	173	4	;	;	PUNCT
cajgh-4	173	5	91(1):6	91(1):6	PROPN
cajgh-4	173	6	-	-	SYM
cajgh-4	173	7	14	14	NUM
cajgh-4	173	8	.	.	PUNCT
cajgh-4	174	1	34	34	NUM
cajgh-4	174	2	.	.	PUNCT
cajgh-4	175	1	aliev	aliev	ADP
cajgh-4	175	2	g	g	PROPN
cajgh-4	175	3	,	,	PUNCT
cajgh-4	175	4	seyidova	seyidova	X
cajgh-4	175	5	d	d	PROPN
cajgh-4	175	6	,	,	PUNCT
cajgh-4	175	7	lamb	lamb	PROPN
cajgh-4	175	8	bt	bt	PROPN
cajgh-4	175	9	,	,	PUNCT
cajgh-4	175	10	obrenovich	obrenovich	ADV
cajgh-4	175	11	me	i	PRON
cajgh-4	175	12	,	,	PUNCT
cajgh-4	175	13	siedlak	siedlak	ADJ
cajgh-4	175	14	sl	sl	NOUN
cajgh-4	175	15	,	,	PUNCT
cajgh-4	175	16	vinters	vinter	NOUN
cajgh-4	175	17	hv	hv	PROPN
cajgh-4	175	18	,	,	PUNCT
cajgh-4	175	19	et	et	PROPN
cajgh-4	175	20	al	al	PROPN
cajgh-4	175	21	.	.	PROPN
cajgh-4	175	22	mitochondria	mitochondria	PROPN
cajgh-4	175	23	and	and	CCONJ
cajgh-4	175	24	vascular	vascular	ADJ
cajgh-4	175	25	lesions	lesion	NOUN
cajgh-4	175	26	as	as	ADP
cajgh-4	175	27	a	a	DET
cajgh-4	175	28	central	central	ADJ
cajgh-4	175	29	target	target	NOUN
cajgh-4	175	30	for	for	ADP
cajgh-4	175	31	the	the	DET
cajgh-4	175	32	development	development	NOUN
cajgh-4	175	33	of	of	ADP
cajgh-4	175	34	alzheimer	alzheimer	PROPN
cajgh-4	175	35	's	's	PART
cajgh-4	175	36	disease	disease	NOUN
cajgh-4	175	37	and	and	CCONJ
cajgh-4	175	38	alzheimer	alzheimer	PROPN
cajgh-4	175	39	disease	disease	NOUN
cajgh-4	175	40	-	-	PUNCT
cajgh-4	175	41	like	like	ADJ
cajgh-4	175	42	pathology	pathology	NOUN
cajgh-4	175	43	in	in	ADP
cajgh-4	175	44	transgenic	transgenic	NOUN
cajgh-4	175	45	mice	mouse	NOUN
cajgh-4	175	46	.	.	PUNCT
cajgh-4	176	1	neurological	neurological	ADJ
cajgh-4	176	2	research	research	NOUN
cajgh-4	176	3	.	.	PUNCT
cajgh-4	177	1	2003;25:665	2003;25:665	NUM
cajgh-4	177	2	-	-	SYM
cajgh-4	177	3	74	74	NUM
cajgh-4	177	4	.	.	PUNCT
cajgh-4	178	1	35	35	NUM
cajgh-4	178	2	.	.	PUNCT
cajgh-4	179	1	magrane	magrane	PROPN
cajgh-4	179	2	j	j	PROPN
cajgh-4	179	3	,	,	PUNCT
cajgh-4	179	4	christensen	christensen	PROPN
cajgh-4	179	5	ra	ra	PROPN
cajgh-4	179	6	,	,	PUNCT
cajgh-4	179	7	rosen	rosen	PROPN
cajgh-4	179	8	km	km	PROPN
cajgh-4	179	9	,	,	PUNCT
cajgh-4	179	10	veereshwarayya	veereshwarayya	PROPN
cajgh-4	179	11	v	v	PROPN
cajgh-4	179	12	,	,	PUNCT
cajgh-4	179	13	querfurth	querfurth	PROPN
cajgh-4	179	14	hw	hw	PROPN
cajgh-4	179	15	.	.	PUNCT
cajgh-4	179	16	dissociation	dissociation	NOUN
cajgh-4	179	17	of	of	ADP
cajgh-4	179	18	erk	erk	PROPN
cajgh-4	179	19	and	and	CCONJ
cajgh-4	179	20	akt	akt	PROPN
cajgh-4	179	21	signaling	signal	VERB
cajgh-4	179	22	in	in	ADP
cajgh-4	179	23	endothelial	endothelial	ADJ
cajgh-4	179	24	cell	cell	NOUN
cajgh-4	179	25	angiogenic	angiogenic	NOUN
cajgh-4	179	26	responses	response	NOUN
cajgh-4	179	27	to	to	ADP
cajgh-4	179	28	[	[	X
cajgh-4	179	29	beta]-amyloid	beta]-amyloid	X
cajgh-4	179	30	.	.	PUNCT
cajgh-4	180	1	experimental	experimental	ADJ
cajgh-4	180	2	cell	cell	NOUN
cajgh-4	180	3	research	research	NOUN
cajgh-4	180	4	.	.	PUNCT
cajgh-4	181	1	2006;312(7):996	2006;312(7):996	X
cajgh-4	181	2	-	-	PROPN
cajgh-4	181	3	1010	1010	NUM
cajgh-4	181	4	.	.	PUNCT
cajgh-4	182	1	36	36	NUM
cajgh-4	182	2	.	.	PUNCT
cajgh-4	183	1	hayashi	hayashi	PROPN
cajgh-4	183	2	s	s	PROPN
cajgh-4	183	3	-	-	PUNCT
cajgh-4	183	4	i	i	PROPN
cajgh-4	183	5	,	,	PUNCT
cajgh-4	183	6	sato	sato	PROPN
cajgh-4	183	7	n	n	PRON
cajgh-4	183	8	,	,	PUNCT
cajgh-4	183	9	yamamoto	yamamoto	PROPN
cajgh-4	183	10	a	a	PROPN
cajgh-4	183	11	,	,	PUNCT
cajgh-4	183	12	ikegame	ikegame	PROPN
cajgh-4	183	13	y	y	PROPN
cajgh-4	183	14	,	,	PUNCT
cajgh-4	183	15	nakashima	nakashima	PROPN
cajgh-4	183	16	s	s	PROPN
cajgh-4	183	17	,	,	PUNCT
cajgh-4	183	18	ogihara	ogihara	PROPN
cajgh-4	183	19	t	t	PROPN
cajgh-4	183	20	,	,	PUNCT
cajgh-4	183	21	et	et	PROPN
cajgh-4	183	22	al	al	PROPN
cajgh-4	183	23	.	.	PROPN
cajgh-4	183	24	alzheimer	alzheimer	PROPN
cajgh-4	183	25	disease	disease	PROPN
cajgh-4	183	26	-	-	PUNCT
cajgh-4	183	27	associated	associate	VERB
cajgh-4	183	28	peptide	peptide	NOUN
cajgh-4	183	29	,	,	PUNCT
cajgh-4	183	30	amyloid	amyloid	NOUN
cajgh-4	183	31	{	{	PUNCT
cajgh-4	183	32	beta}40	beta}40	NOUN
cajgh-4	183	33	,	,	PUNCT
cajgh-4	183	34	inhibits	inhibit	VERB
cajgh-4	183	35	vascular	vascular	ADJ
cajgh-4	183	36	regeneration	regeneration	NOUN
cajgh-4	183	37	with	with	ADP
cajgh-4	183	38	induction	induction	NOUN
cajgh-4	183	39	of	of	ADP
cajgh-4	183	40	endothelial	endothelial	ADJ
cajgh-4	183	41	autophagy	autophagy	NOUN
cajgh-4	183	42	.	.	PUNCT
cajgh-4	184	1	arterioscler	arterioscler	PROPN
cajgh-4	184	2	thromb	thromb	PROPN
cajgh-4	184	3	vasc	vasc	PROPN
cajgh-4	184	4	biol	biol	PROPN
cajgh-4	184	5	.	.	PUNCT
cajgh-4	185	1	2009;29(11):1909	2009;29(11):1909	NUM
cajgh-4	185	2	-	-	SYM
cajgh-4	185	3	15	15	NUM
cajgh-4	185	4	.	.	PUNCT
cajgh-4	186	1	37	37	NUM
cajgh-4	186	2	.	.	PUNCT
cajgh-4	187	1	price	price	PROPN
cajgh-4	187	2	jm	jm	PROPN
cajgh-4	187	3	,	,	PUNCT
cajgh-4	187	4	chi	chi	PROPN
cajgh-4	187	5	x	x	NOUN
cajgh-4	187	6	,	,	PUNCT
cajgh-4	187	7	hellermann	hellermann	PROPN
cajgh-4	187	8	g	g	PROPN
cajgh-4	187	9	,	,	PUNCT
cajgh-4	187	10	sutton	sutton	PROPN
cajgh-4	187	11	et	et	PROPN
cajgh-4	187	12	.	.	PUNCT
cajgh-4	188	1	physiological	physiological	ADJ
cajgh-4	188	2	levels	level	NOUN
cajgh-4	188	3	of	of	ADP
cajgh-4	188	4	-amyloid	-amyloid	PROPN
cajgh-4	188	5	induce	induce	VERB
cajgh-4	188	6	cerebral	cerebral	ADJ
cajgh-4	188	7	vessel	vessel	NOUN
cajgh-4	188	8	dysfunction	dysfunction	NOUN
cajgh-4	188	9	and	and	CCONJ
cajgh-4	188	10	reduce	reduce	VERB
cajgh-4	188	11	endothelial	endothelial	ADJ
cajgh-4	188	12	nitric	nitric	ADJ
cajgh-4	188	13	oxide	oxide	NOUN
cajgh-4	188	14	production	production	NOUN
cajgh-4	188	15	.	.	PUNCT
cajgh-4	189	1	neurological	neurological	ADJ
cajgh-4	189	2	research	research	NOUN
cajgh-4	189	3	.	.	PUNCT
cajgh-4	190	1	2001;23:506	2001;23:506	NUM
cajgh-4	190	2	-	-	SYM
cajgh-4	190	3	12	12	NUM
cajgh-4	190	4	.	.	PUNCT
cajgh-4	191	1	38	38	NUM
cajgh-4	191	2	.	.	PUNCT
cajgh-4	192	1	emmanuelle	emmanuelle	PROPN
cajgh-4	192	2	mb	mb	PROPN
cajgh-4	192	3	,	,	PUNCT
cajgh-4	192	4	michal	michal	PROPN
cajgh-4	192	5	t	t	PROPN
cajgh-4	192	6	,	,	PUNCT
cajgh-4	192	7	robert	robert	PROPN
cajgh-4	192	8	jm	jm	PROPN
cajgh-4	192	9	,	,	PUNCT
cajgh-4	192	10	bernhard	bernhard	PROPN
cajgh-4	192	11	h.	h.	PROPN
cajgh-4	192	12	amyloid	amyloid	PROPN
cajgh-4	192	13	β	β	X
cajgh-4	192	14	-	-	ADJ
cajgh-4	192	15	peptide	peptide	ADJ
cajgh-4	192	16	induces	induce	VERB
cajgh-4	192	17	cell	cell	NOUN
cajgh-4	192	18	monolayer	monolayer	NOUN
cajgh-4	192	19	albumin	albumin	NOUN
cajgh-4	192	20	permeability	permeability	NOUN
cajgh-4	192	21	,	,	PUNCT
cajgh-4	192	22	impairs	impair	VERB
cajgh-4	192	23	glucose	glucose	NOUN
cajgh-4	192	24	transport	transport	NOUN
cajgh-4	192	25	,	,	PUNCT
cajgh-4	192	26	and	and	CCONJ
cajgh-4	192	27	induces	induce	VERB
cajgh-4	192	28	apoptosis	apoptosis	NOUN
cajgh-4	192	29	in	in	ADP
cajgh-4	192	30	vascular	vascular	ADJ
cajgh-4	192	31	endothelial	endothelial	ADJ
cajgh-4	192	32	cells	cell	NOUN
cajgh-4	192	33	.	.	PUNCT
cajgh-4	193	1	journal	journal	NOUN
cajgh-4	193	2	of	of	ADP
cajgh-4	193	3	neurochemistry	neurochemistry	NOUN
cajgh-4	193	4	.	.	PUNCT
cajgh-4	194	1	1997;68(5):1870	1997;68(5):1870	NUM
cajgh-4	194	2	-	-	SYM
cajgh-4	194	3	81	81	NUM
cajgh-4	194	4	.	.	PUNCT
cajgh-4	194	5	39	39	NUM
cajgh-4	194	6	.	.	PUNCT
cajgh-4	195	1	bhatia	bhatia	PROPN
cajgh-4	195	2	r	r	PROPN
cajgh-4	195	3	,	,	PUNCT
cajgh-4	195	4	lin	lin	PROPN
cajgh-4	195	5	hai	hai	PROPN
cajgh-4	195	6	,	,	PUNCT
cajgh-4	195	7	lal	lal	PROPN
cajgh-4	195	8	r.	r.	PROPN
cajgh-4	195	9	fresh	fresh	PROPN
cajgh-4	195	10	and	and	CCONJ
cajgh-4	195	11	globular	globular	ADJ
cajgh-4	195	12	amyloid	amyloid	NOUN
cajgh-4	195	13	{	{	PUNCT
cajgh-4	195	14	beta	beta	NOUN
cajgh-4	195	15	}	}	PUNCT
cajgh-4	195	16	protein	protein	NOUN
cajgh-4	195	17	(	(	PUNCT
cajgh-4	195	18	1	1	NUM
cajgh-4	195	19	-	-	SYM
cajgh-4	195	20	42	42	NUM
cajgh-4	195	21	)	)	PUNCT
cajgh-4	195	22	induces	induce	VERB
cajgh-4	195	23	rapid	rapid	ADJ
cajgh-4	195	24	cellular	cellular	ADJ
cajgh-4	195	25	degeneration	degeneration	NOUN
cajgh-4	195	26	:	:	PUNCT
cajgh-4	195	27	evidence	evidence	NOUN
cajgh-4	195	28	for	for	ADP
cajgh-4	195	29	a{beta}p	a{beta}p	PROPN
cajgh-4	195	30	channel	channel	NOUN
cajgh-4	195	31	-	-	PUNCT
cajgh-4	195	32	mediated	mediate	VERB
cajgh-4	195	33	cellular	cellular	ADJ
cajgh-4	195	34	toxicity	toxicity	NOUN
cajgh-4	195	35	.	.	PUNCT
cajgh-4	196	1	faseb	faseb	PROPN
cajgh-4	196	2	j.	j.	PROPN
cajgh-4	196	3	2000;14(9):1233	2000;14(9):1233	PROPN
cajgh-4	196	4	-	-	SYM
cajgh-4	196	5	43	43	NUM
cajgh-4	196	6	.	.	PUNCT
cajgh-4	197	1	40	40	NUM
cajgh-4	197	2	.	.	PUNCT
cajgh-4	198	1	xu	xu	PROPN
cajgh-4	198	2	j	j	PROPN
cajgh-4	198	3	,	,	PUNCT
cajgh-4	198	4	chen	chen	PROPN
cajgh-4	198	5	s	s	PROPN
cajgh-4	198	6	,	,	PUNCT
cajgh-4	198	7	ku	ku	PROPN
cajgh-4	198	8	g	g	PROPN
cajgh-4	198	9	,	,	PUNCT
cajgh-4	198	10	ahmed	ahmed	PROPN
cajgh-4	198	11	sh	sh	PROPN
cajgh-4	198	12	,	,	PUNCT
cajgh-4	198	13	xu	xu	PROPN
cajgh-4	198	14	j	j	PROPN
cajgh-4	198	15	,	,	PUNCT
cajgh-4	198	16	chen	chen	PROPN
cajgh-4	198	17	h	h	PROPN
cajgh-4	198	18	,	,	PUNCT
cajgh-4	198	19	et	et	PROPN
cajgh-4	198	20	al	al	PROPN
cajgh-4	198	21	.	.	PUNCT
cajgh-4	198	22	amyloid	amyloid	PROPN
cajgh-4	198	23	beta	beta	ADJ
cajgh-4	198	24	peptide	peptide	NOUN
cajgh-4	198	25	-	-	PUNCT
cajgh-4	198	26	induced	induce	VERB
cajgh-4	198	27	cerebral	cerebral	ADJ
cajgh-4	198	28	endothelial	endothelial	ADJ
cajgh-4	198	29	cell	cell	NOUN
cajgh-4	198	30	death	death	NOUN
cajgh-4	198	31	involves	involve	VERB
cajgh-4	198	32	mitochondrial	mitochondrial	ADJ
cajgh-4	198	33	dysfunction	dysfunction	NOUN
cajgh-4	198	34	and	and	CCONJ
cajgh-4	198	35	caspase	caspase	NOUN
cajgh-4	198	36	activation	activation	NOUN
cajgh-4	198	37	.	.	PUNCT
cajgh-4	199	1	j	j	PROPN
cajgh-4	199	2	cereb	cereb	PROPN
cajgh-4	199	3	blood	blood	NOUN
cajgh-4	199	4	flow	flow	NOUN
cajgh-4	199	5	metab	metab	NOUN
cajgh-4	199	6	.	.	PUNCT
cajgh-4	200	1	2001;21(6):702	2001;21(6):702	NUM
cajgh-4	200	2	-	-	SYM
cajgh-4	200	3	10	10	NUM
cajgh-4	200	4	.	.	PUNCT
cajgh-4	201	1	41	41	NUM
cajgh-4	201	2	.	.	PUNCT
cajgh-4	202	1	selkoe	selkoe	PROPN
cajgh-4	202	2	djas	djas	PROPN
cajgh-4	202	3	,	,	PUNCT
cajgh-4	202	4	d.	d.	PROPN
cajgh-4	202	5	alzheimer	alzheimer	PROPN
cajgh-4	202	6	's	's	PART
cajgh-4	202	7	disease	disease	NOUN
cajgh-4	202	8	:	:	PUNCT
cajgh-4	202	9	molecular	molecular	ADJ
cajgh-4	202	10	understanding	understanding	NOUN
cajgh-4	202	11	predicts	predict	VERB
cajgh-4	202	12	amyloid	amyloid	NOUN
cajgh-4	202	13	-	-	PUNCT
cajgh-4	202	14	based	base	VERB
cajgh-4	202	15	therapeutics	therapeutic	NOUN
cajgh-4	202	16	.	.	PUNCT
cajgh-4	203	1	annu	annu	PROPN
cajgh-4	203	2	rev	rev	VERB
cajgh-4	203	3	pharmacol	pharmacol	PROPN
cajgh-4	203	4	toxicol	toxicol	PROPN
cajgh-4	203	5	.	.	PUNCT
cajgh-4	204	1	2003;(43):545	2003;(43):545	NOUN
cajgh-4	204	2	-	-	PUNCT
cajgh-4	204	3	84	84	NUM
cajgh-4	204	4	.	.	PUNCT
cajgh-4	205	1	42	42	NUM
cajgh-4	205	2	.	.	PUNCT
cajgh-4	206	1	kalaria	kalaria	PROPN
cajgh-4	206	2	rn	rn	PROPN
cajgh-4	206	3	.	.	PROPN
cajgh-4	206	4	cerebrovascular	cerebrovascular	ADJ
cajgh-4	206	5	degeneration	degeneration	NOUN
cajgh-4	206	6	is	be	AUX
cajgh-4	206	7	related	relate	VERB
cajgh-4	206	8	to	to	ADP
cajgh-4	206	9	amyloid	amyloid	NOUN
cajgh-4	206	10	-	-	PUNCT
cajgh-4	206	11	β	β	X
cajgh-4	206	12	protein	protein	NOUN
cajgh-4	206	13	deposition	deposition	NOUN
cajgh-4	206	14	in	in	ADP
cajgh-4	206	15	alzheimer	alzheimer	PROPN
cajgh-4	206	16	's	's	PART
cajgh-4	206	17	disease	disease	NOUN
cajgh-4	206	18	.	.	PUNCT
cajgh-4	207	1	annals	annal	NOUN
cajgh-4	207	2	of	of	ADP
cajgh-4	207	3	the	the	DET
cajgh-4	207	4	new	new	PROPN
cajgh-4	207	5	york	york	PROPN
cajgh-4	207	6	academy	academy	PROPN
cajgh-4	207	7	of	of	ADP
cajgh-4	207	8	sciences	sciences	PROPN
cajgh-4	207	9	.	.	PUNCT
cajgh-4	208	1	2006;826(issue	2006;826(issue	VERB
cajgh-4	208	2	cerebrovascular	cerebrovascular	ADJ
cajgh-4	208	3	pathology	pathology	NOUN
cajgh-4	208	4	in	in	ADP
cajgh-4	208	5	alzheimer	alzheimer	PROPN
cajgh-4	208	6	's	's	PART
cajgh-4	208	7	disease):263	disease):263	PROPN
cajgh-4	208	8	-	-	SYM
cajgh-4	208	9	71	71	NUM
cajgh-4	208	10	.	.	PUNCT
cajgh-4	209	1	43	43	NUM
cajgh-4	209	2	.	.	PUNCT
cajgh-4	210	1	park	park	PROPN
cajgh-4	210	2	l	l	PROPN
cajgh-4	210	3	aj	aj	PROPN
cajgh-4	210	4	,	,	PUNCT
cajgh-4	210	5	forster	forster	PROPN
cajgh-4	210	6	c	c	PROPN
cajgh-4	210	7	,	,	PUNCT
cajgh-4	210	8	kazama	kazama	PROPN
cajgh-4	210	9	k	k	PROPN
cajgh-4	210	10	,	,	PUNCT
cajgh-4	210	11	carlson	carlson	PROPN
cajgh-4	210	12	ga	ga	PROPN
cajgh-4	210	13	,	,	PUNCT
cajgh-4	210	14	iadecola	iadecola	PROPN
cajgh-4	210	15	c.	c.	PROPN
cajgh-4	210	16	abeta	abeta	PROPN
cajgh-4	210	17	-	-	PUNCT
cajgh-4	210	18	induced	induce	VERB
cajgh-4	210	19	vascular	vascular	ADJ
cajgh-4	210	20	oxidative	oxidative	ADJ
cajgh-4	210	21	stress	stress	NOUN
cajgh-4	210	22	and	and	CCONJ
cajgh-4	210	23	attenuation	attenuation	NOUN
cajgh-4	210	24	of	of	ADP
cajgh-4	210	25	functional	functional	ADJ
cajgh-4	210	26	hyperemia	hyperemia	NOUN
cajgh-4	210	27	in	in	ADP
cajgh-4	210	28	mouse	mouse	NOUN
cajgh-4	210	29	somatosensory	somatosensory	NOUN
cajgh-4	210	30	cortex	cortex	NOUN
cajgh-4	210	31	.	.	PUNCT
cajgh-4	211	1	joyrnal	joyrnal	ADJ
cajgh-4	211	2	of	of	ADP
cajgh-4	211	3	cerebral	cerebral	ADJ
cajgh-4	211	4	blood	blood	NOUN
cajgh-4	211	5	flow	flow	NOUN
cajgh-4	211	6	metabolism	metabolism	NOUN
cajgh-4	211	7	.	.	PUNCT
cajgh-4	212	1	2004;24(3):334	2004;24(3):334	NUM
cajgh-4	212	2	-	-	SYM
cajgh-4	212	3	42	42	NUM
cajgh-4	212	4	.	.	PUNCT
cajgh-4	213	1	44	44	NUM
cajgh-4	213	2	.	.	PUNCT
cajgh-4	214	1	iadecola	iadecola	PROPN
cajgh-4	215	1	c	c	PROPN
cajgh-4	215	2	zf	zf	PROPN
cajgh-4	215	3	,	,	PUNCT
cajgh-4	215	4	niwa	niwa	PROPN
cajgh-4	215	5	k	k	PROPN
cajgh-4	215	6	,	,	PUNCT
cajgh-4	215	7	eckman	eckman	NOUN
cajgh-4	215	8	c	c	PROPN
cajgh-4	215	9	,	,	PUNCT
cajgh-4	215	10	turner	turner	PROPN
cajgh-4	215	11	sk	sk	PROPN
cajgh-4	215	12	,	,	PUNCT
cajgh-4	215	13	fischer	fischer	PROPN
cajgh-4	215	14	e	e	PROPN
cajgh-4	215	15	,	,	PUNCT
cajgh-4	215	16	younkin	younkin	NOUN
cajgh-4	215	17	s	s	PROPN
cajgh-4	215	18	,	,	PUNCT
cajgh-4	215	19	borchelt	borchelt	PROPN
cajgh-4	215	20	dr	dr	PROPN
cajgh-4	215	21	,	,	PUNCT
cajgh-4	215	22	hsiao	hsiao	PROPN
cajgh-4	215	23	kk	kk	PROPN
cajgh-4	215	24	,	,	PUNCT
cajgh-4	215	25	carlson	carlson	PROPN
cajgh-4	215	26	ga	ga	PROPN
cajgh-4	215	27	.	.	PUNCT
cajgh-4	216	1	sod1	sod1	PROPN
cajgh-4	216	2	rescues	rescue	VERB
cajgh-4	216	3	cerebral	cerebral	ADJ
cajgh-4	216	4	endothelial	endothelial	ADJ
cajgh-4	216	5	dysfunction	dysfunction	NOUN
cajgh-4	216	6	in	in	ADP
cajgh-4	216	7	mice	mice	NOUN
cajgh-4	216	8	overexpressing	overexpresse	VERB
cajgh-4	216	9	amyloid	amyloid	NOUN
cajgh-4	216	10	precursor	precursor	NOUN
cajgh-4	216	11	protein	protein	NOUN
cajgh-4	216	12	.	.	PUNCT
cajgh-4	217	1	nature	nature	NOUN
cajgh-4	217	2	neuroscience	neuroscience	NOUN
cajgh-4	217	3	.	.	PUNCT
cajgh-4	218	1	1999;2(2):157	1999;2(2):157	NUM
cajgh-4	218	2	-	-	SYM
cajgh-4	218	3	61	61	NUM
cajgh-4	218	4	.	.	PUNCT
cajgh-4	219	1	45	45	NUM
cajgh-4	219	2	.	.	PUNCT
cajgh-4	220	1	tong	tong	PROPN
cajgh-4	220	2	x	x	PROPN
cajgh-4	220	3	-	-	PROPN
cajgh-4	220	4	k	k	PROPN
cajgh-4	220	5	,	,	PUNCT
cajgh-4	220	6	nicolakakis	nicolakakis	PROPN
cajgh-4	220	7	n	n	CCONJ
cajgh-4	220	8	,	,	PUNCT
cajgh-4	220	9	kocharyan	kocharyan	VERB
cajgh-4	220	10	a	a	PRON
cajgh-4	220	11	,	,	PUNCT
cajgh-4	220	12	hamel	hamel	PROPN
cajgh-4	220	13	e.	e.	PROPN
cajgh-4	220	14	vascular	vascular	PROPN
cajgh-4	220	15	remodeling	remodeling	NOUN
cajgh-4	220	16	versus	versus	ADP
cajgh-4	220	17	amyloid	amyloid	NOUN
cajgh-4	220	18	-	-	PUNCT
cajgh-4	220	19	beta	beta	NOUN
cajgh-4	220	20	-	-	PUNCT
cajgh-4	220	21	induced	induce	VERB
cajgh-4	220	22	oxidative	oxidative	ADJ
cajgh-4	220	23	stress	stress	NOUN
cajgh-4	220	24	in	in	ADP
cajgh-4	220	25	the	the	DET
cajgh-4	220	26	cerebrovascular	cerebrovascular	ADJ
cajgh-4	220	27	dysfunctions	dysfunction	NOUN
cajgh-4	220	28	associated	associate	VERB
cajgh-4	220	29	with	with	ADP
cajgh-4	220	30	alzheimer	alzheimer	PROPN
cajgh-4	220	31	's	's	PART
cajgh-4	220	32	disease	disease	NOUN
cajgh-4	220	33	.	.	PUNCT
cajgh-4	221	1	j	j	PROPN
cajgh-4	221	2	neurosci	neurosci	PROPN
cajgh-4	221	3	.	.	PUNCT
cajgh-4	222	1	2005;25(48):11165	2005;25(48):11165	X
cajgh-4	222	2	-	-	SYM
cajgh-4	222	3	74	74	NUM
cajgh-4	222	4	.	.	PUNCT
cajgh-4	223	1	46	46	NUM
cajgh-4	223	2	.	.	PUNCT
cajgh-4	223	3	abramov	abramov	PROPN
cajgh-4	224	1	ay	ay	PROPN
cajgh-4	224	2	,	,	PUNCT
cajgh-4	224	3	duchen	duchen	PROPN
cajgh-4	224	4	mr	mr	PROPN
cajgh-4	224	5	.	.	PROPN
cajgh-4	225	1	the	the	DET
cajgh-4	225	2	role	role	NOUN
cajgh-4	225	3	of	of	ADP
cajgh-4	225	4	an	an	DET
cajgh-4	225	5	astrocytic	astrocytic	ADJ
cajgh-4	225	6	nadph	nadph	ADJ
cajgh-4	225	7	oxidase	oxidase	NOUN
cajgh-4	225	8	in	in	ADP
cajgh-4	225	9	the	the	DET
cajgh-4	225	10	neurotoxicity	neurotoxicity	NOUN
cajgh-4	225	11	of	of	ADP
cajgh-4	225	12	amyloid	amyloid	NOUN
cajgh-4	225	13	beta	beta	NOUN
cajgh-4	225	14	peptides	peptide	NOUN
cajgh-4	225	15	.	.	PUNCT
cajgh-4	226	1	philosophical	philosophical	ADJ
cajgh-4	226	2	transactions	transaction	NOUN
cajgh-4	226	3	of	of	ADP
cajgh-4	226	4	the	the	DET
cajgh-4	226	5	royal	royal	ADJ
cajgh-4	226	6	society	society	NOUN
cajgh-4	226	7	b	b	PROPN
cajgh-4	226	8	:	:	PUNCT
cajgh-4	226	9	biological	biological	ADJ
cajgh-4	226	10	sciences	science	NOUN
cajgh-4	226	11	.	.	PUNCT
cajgh-4	227	1	2005;360(1464):2309	2005;360(1464):2309	NUM
cajgh-4	227	2	-	-	SYM
cajgh-4	227	3	14	14	NUM
cajgh-4	227	4	.	.	PUNCT
cajgh-4	228	1	47	47	NUM
cajgh-4	228	2	.	.	PUNCT
cajgh-4	229	1	yin	yin	PROPN
cajgh-4	229	2	kj	kj	PROPN
cajgh-4	229	3	,	,	PUNCT
cajgh-4	229	4	lee	lee	PROPN
cajgh-4	229	5	jm	jm	PROPN
cajgh-4	229	6	,	,	PUNCT
cajgh-4	229	7	chen	chen	PROPN
cajgh-4	229	8	sd	sd	PROPN
cajgh-4	229	9	,	,	PUNCT
cajgh-4	229	10	xu	xu	PROPN
cajgh-4	229	11	j	j	PROPN
cajgh-4	229	12	,	,	PUNCT
cajgh-4	229	13	hsu	hsu	PROPN
cajgh-4	229	14	cy	cy	PROPN
cajgh-4	229	15	.	.	PUNCT
cajgh-4	229	16	amyloid	amyloid	NOUN
cajgh-4	229	17	-	-	PUNCT
cajgh-4	229	18	beta	beta	NOUN
cajgh-4	229	19	induces	induce	VERB
cajgh-4	229	20	smac	smac	PROPN
cajgh-4	229	21	release	release	NOUN
cajgh-4	229	22	via	via	ADP
cajgh-4	229	23	ap-1	ap-1	ADV
cajgh-4	229	24	/	/	SYM
cajgh-4	229	25	bim	bim	NOUN
cajgh-4	229	26	activation	activation	NOUN
cajgh-4	229	27	in	in	ADP
cajgh-4	229	28	cerebral	cerebral	ADJ
cajgh-4	229	29	endothelial	endothelial	ADJ
cajgh-4	229	30	cells	cell	NOUN
cajgh-4	229	31	.	.	PUNCT
cajgh-4	230	1	j	j	PROPN
cajgh-4	230	2	neurosci	neurosci	PROPN
cajgh-4	230	3	.	.	PUNCT
cajgh-4	231	1	2002;22(22):9764	2002;22(22):9764	NUM
cajgh-4	231	2	-	-	SYM
cajgh-4	231	3	70	70	NUM
cajgh-4	231	4	.	.	PUNCT
cajgh-4	232	1	48	48	NUM
cajgh-4	232	2	.	.	PUNCT
cajgh-4	233	1	hsu	hsu	PROPN
cajgh-4	233	2	m	m	PROPN
cajgh-4	233	3	-	-	PROPN
cajgh-4	233	4	j	j	PROPN
cajgh-4	233	5	,	,	PUNCT
cajgh-4	233	6	hsu	hsu	PROPN
cajgh-4	233	7	cy	cy	PROPN
cajgh-4	233	8	,	,	PUNCT
cajgh-4	233	9	chen	chen	PROPN
cajgh-4	233	10	b	b	PROPN
cajgh-4	233	11	-	-	PUNCT
cajgh-4	233	12	c	c	PROPN
cajgh-4	233	13	,	,	PUNCT
cajgh-4	233	14	chen	chen	PROPN
cajgh-4	233	15	m	m	PROPN
cajgh-4	233	16	-	-	PUNCT
cajgh-4	233	17	c	c	PROPN
cajgh-4	233	18	,	,	PUNCT
cajgh-4	233	19	ou	ou	ADP
cajgh-4	233	20	g	g	PROPN
cajgh-4	233	21	,	,	PUNCT
cajgh-4	233	22	lin	lin	PROPN
cajgh-4	233	23	c	c	PROPN
cajgh-4	233	24	-	-	PUNCT
cajgh-4	233	25	h.	h.	NOUN
cajgh-4	233	26	apoptosis	apoptosis	NOUN
cajgh-4	233	27	signal	signal	NOUN
cajgh-4	233	28	-	-	PUNCT
cajgh-4	233	29	regulating	regulate	VERB
cajgh-4	233	30	kinase	kinase	NOUN
cajgh-4	233	31	1	1	NUM
cajgh-4	233	32	in	in	ADP
cajgh-4	233	33	amyloid	amyloid	NOUN
cajgh-4	233	34	{	{	PUNCT
cajgh-4	233	35	beta	beta	NOUN
cajgh-4	233	36	}	}	PUNCT
cajgh-4	233	37	peptide	peptide	NOUN
cajgh-4	233	38	-	-	PUNCT
cajgh-4	233	39	induced	induce	VERB
cajgh-4	233	40	cerebral	cerebral	ADJ
cajgh-4	233	41	endothelial	endothelial	ADJ
cajgh-4	233	42	cell	cell	NOUN
cajgh-4	233	43	apoptosis	apoptosis	NOUN
cajgh-4	233	44	.	.	PUNCT
cajgh-4	234	1	j	j	PROPN
cajgh-4	234	2	neurosci	neurosci	PROPN
cajgh-4	234	3	.	.	PUNCT
cajgh-4	235	1	2007;27(21):5719	2007;27(21):5719	NUM
cajgh-4	235	2	-	-	SYM
cajgh-4	235	3	29	29	NUM
cajgh-4	235	4	.	.	PUNCT
cajgh-4	235	5	49	49	NUM
cajgh-4	235	6	.	.	PUNCT
cajgh-4	236	1	grammas	grammas	PROPN
cajgh-4	236	2	p	p	NOUN
cajgh-4	236	3	,	,	PUNCT
cajgh-4	236	4	ovase	ovase	PROPN
cajgh-4	236	5	r.	r.	NOUN
cajgh-4	236	6	inflammatory	inflammatory	ADJ
cajgh-4	236	7	factors	factor	NOUN
cajgh-4	236	8	are	be	AUX
cajgh-4	236	9	elevated	elevate	VERB
cajgh-4	236	10	in	in	ADP
cajgh-4	236	11	brain	brain	NOUN
cajgh-4	236	12	microvessels	microvessel	NOUN
cajgh-4	236	13	in	in	ADP
cajgh-4	236	14	alzheimer	alzheimer	PROPN
cajgh-4	236	15	's	's	PART
cajgh-4	236	16	disease	disease	NOUN
cajgh-4	236	17	.	.	PUNCT
cajgh-4	237	1	neurobiology	neurobiology	NOUN
cajgh-4	237	2	of	of	ADP
cajgh-4	237	3	aging	aging	NOUN
cajgh-4	237	4	.	.	PUNCT
cajgh-4	238	1	2001;22(6):837	2001;22(6):837	NUM
cajgh-4	238	2	-	-	SYM
cajgh-4	238	3	42	42	NUM
cajgh-4	238	4	.	.	PUNCT
cajgh-4	239	1	50	50	NUM
cajgh-4	239	2	.	.	PUNCT
cajgh-4	240	1	vukic	vukic	PROPN
cajgh-4	240	2	v	v	NOUN
cajgh-4	240	3	,	,	PUNCT
cajgh-4	240	4	callaghan	callaghan	PROPN
cajgh-4	240	5	d	d	PROPN
cajgh-4	240	6	,	,	PUNCT
cajgh-4	240	7	walker	walker	PROPN
cajgh-4	240	8	d	d	PROPN
cajgh-4	240	9	,	,	PUNCT
cajgh-4	240	10	lue	lue	PROPN
cajgh-4	240	11	l	l	PROPN
cajgh-4	240	12	-	-	PROPN
cajgh-4	240	13	f	f	PROPN
cajgh-4	240	14	,	,	PUNCT
cajgh-4	240	15	liu	liu	PROPN
cajgh-4	240	16	qy	qy	PROPN
cajgh-4	240	17	,	,	PUNCT
cajgh-4	240	18	couraud	couraud	VERB
cajgh-4	240	19	p	p	X
cajgh-4	240	20	-	-	PUNCT
cajgh-4	240	21	o	o	NOUN
cajgh-4	240	22	,	,	PUNCT
cajgh-4	240	23	et	et	PROPN
cajgh-4	240	24	al	al	PROPN
cajgh-4	241	1	.	.	PUNCT
cajgh-4	241	2	expression	expression	NOUN
cajgh-4	241	3	of	of	ADP
cajgh-4	241	4	inflammatory	inflammatory	ADJ
cajgh-4	241	5	genes	gene	NOUN
cajgh-4	241	6	induced	induce	VERB
cajgh-4	241	7	by	by	ADP
cajgh-4	241	8	beta	beta	NOUN
cajgh-4	241	9	-	-	PUNCT
cajgh-4	241	10	amyloid	amyloid	NOUN
cajgh-4	241	11	peptides	peptide	NOUN
cajgh-4	241	12	in	in	ADP
cajgh-4	241	13	human	human	ADJ
cajgh-4	241	14	brain	brain	NOUN
cajgh-4	241	15	endothelial	endothelial	NOUN
cajgh-4	241	16	cells	cell	NOUN
cajgh-4	241	17	and	and	CCONJ
cajgh-4	241	18	in	in	ADP
cajgh-4	241	19	alzheimer	alzheimer	PROPN
cajgh-4	241	20	's	's	PART
cajgh-4	241	21	brain	brain	NOUN
cajgh-4	241	22	is	be	AUX
cajgh-4	241	23	mediated	mediate	VERB
cajgh-4	241	24	by	by	ADP
cajgh-4	241	25	the	the	DET
cajgh-4	241	26	jnk	jnk	PROPN
cajgh-4	241	27	-	-	PUNCT
cajgh-4	241	28	ap1	ap1	PROPN
cajgh-4	241	29	signaling	signal	VERB
cajgh-4	241	30	pathway	pathway	NOUN
cajgh-4	241	31	.	.	PUNCT
cajgh-4	242	1	neurobiology	neurobiology	NOUN
cajgh-4	242	2	of	of	ADP
cajgh-4	242	3	disease	disease	NOUN
cajgh-4	242	4	.	.	PUNCT
cajgh-4	243	1	2009;34(1):95	2009;34(1):95	NUM
cajgh-4	243	2	-	-	SYM
cajgh-4	243	3	106	106	NUM
cajgh-4	243	4	.	.	PUNCT
cajgh-4	244	1	51	51	NUM
cajgh-4	244	2	.	.	PUNCT
cajgh-4	244	3	tan	tan	PROPN
cajgh-4	244	4	j	j	PROPN
cajgh-4	244	5	,	,	PUNCT
cajgh-4	244	6	town	town	NOUN
cajgh-4	244	7	t	t	PROPN
cajgh-4	244	8	,	,	PUNCT
cajgh-4	244	9	suo	suo	PROPN
cajgh-4	244	10	z	z	PROPN
cajgh-4	244	11	,	,	PUNCT
cajgh-4	244	12	wu	wu	PROPN
cajgh-4	244	13	y	y	PROPN
cajgh-4	244	14	,	,	PUNCT
cajgh-4	244	15	song	song	NOUN
cajgh-4	244	16	s	s	PROPN
cajgh-4	244	17	,	,	PUNCT
cajgh-4	244	18	kundtz	kundtz	PROPN
cajgh-4	244	19	a	a	PROPN
cajgh-4	244	20	,	,	PUNCT
cajgh-4	244	21	et	et	PROPN
cajgh-4	244	22	al	al	PROPN
cajgh-4	244	23	.	.	PROPN
cajgh-4	244	24	induction	induction	NOUN
cajgh-4	244	25	of	of	ADP
cajgh-4	244	26	cd40	cd40	PROPN
cajgh-4	244	27	on	on	ADP
cajgh-4	244	28	human	human	ADJ
cajgh-4	244	29	endothelial	endothelial	ADJ
cajgh-4	244	30	cells	cell	NOUN
cajgh-4	244	31	by	by	ADP
cajgh-4	244	32	alzheimer	alzheimer	PROPN
cajgh-4	244	33	's	's	PART
cajgh-4	244	34	[	[	X
cajgh-4	244	35	beta]-amyloid	beta]-amyloid	NOUN
cajgh-4	244	36	peptides	peptide	NOUN
cajgh-4	244	37	.	.	PUNCT
cajgh-4	245	1	brain	brain	NOUN
cajgh-4	245	2	research	research	NOUN
cajgh-4	245	3	bulletin	bulletin	NOUN
cajgh-4	245	4	.	.	PUNCT
cajgh-4	246	1	1999;50(2):143	1999;50(2):143	PROPN
cajgh-4	246	2	-	-	SYM
cajgh-4	246	3	8	8	NUM
cajgh-4	246	4	.	.	NOUN
cajgh-4	246	5	52	52	NUM
cajgh-4	246	6	.	.	PUNCT
cajgh-4	247	1	suo	suo	PROPN
cajgh-4	247	2	z	z	PROPN
cajgh-4	247	3	,	,	PUNCT
cajgh-4	247	4	tan	tan	PROPN
cajgh-4	247	5	j	j	PROPN
cajgh-4	247	6	,	,	PUNCT
cajgh-4	247	7	placzek	placzek	VERB
cajgh-4	247	8	a	a	PRON
cajgh-4	247	9	,	,	PUNCT
cajgh-4	247	10	crawford	crawford	PROPN
cajgh-4	247	11	f	f	PROPN
cajgh-4	247	12	,	,	PUNCT
cajgh-4	247	13	fang	fang	PROPN
cajgh-4	247	14	c	c	PROPN
cajgh-4	247	15	,	,	PUNCT
cajgh-4	247	16	mullan	mullan	PROPN
cajgh-4	247	17	m.	m.	PROPN
cajgh-4	247	18	alzheimer	alzheimer	PROPN
cajgh-4	247	19	's	's	PART
cajgh-4	247	20	[	[	X
cajgh-4	247	21	beta]-amyloid	beta]-amyloid	NOUN
cajgh-4	247	22	peptides	peptide	NOUN
cajgh-4	247	23	induce	induce	VERB
cajgh-4	247	24	inflammatory	inflammatory	ADJ
cajgh-4	247	25	cascade	cascade	NOUN
cajgh-4	247	26	in	in	ADP
cajgh-4	247	27	human	human	ADJ
cajgh-4	247	28	vascular	vascular	ADJ
cajgh-4	247	29	cells	cell	NOUN
cajgh-4	247	30	:	:	PUNCT
cajgh-4	247	31	the	the	DET
cajgh-4	247	32	roles	role	NOUN
cajgh-4	247	33	of	of	ADP
cajgh-4	247	34	cytokines	cytokine	NOUN
cajgh-4	247	35	and	and	CCONJ
cajgh-4	247	36	cd40	cd40	PROPN
cajgh-4	247	37	.	.	PROPN
cajgh-4	247	38	brain	brain	NOUN
cajgh-4	247	39	research	research	NOUN
cajgh-4	247	40	.	.	PUNCT
cajgh-4	248	1	1998;807(1	1998;807(1	X
cajgh-4	248	2	-	-	SYM
cajgh-4	248	3	2):110	2):110	PROPN
cajgh-4	248	4	-	-	PUNCT
cajgh-4	248	5	7	7	NUM
cajgh-4	248	6	.	.	NUM
cajgh-4	249	1	53	53	NUM
cajgh-4	249	2	.	.	PUNCT
cajgh-4	250	1	callaghan	callaghan	PROPN
cajgh-4	250	2	d	d	PROPN
cajgh-4	250	3	,	,	PUNCT
cajgh-4	250	4	bai	bai	PROPN
cajgh-4	250	5	j	j	PROPN
cajgh-4	250	6	,	,	PUNCT
cajgh-4	250	7	huang	huang	PROPN
cajgh-4	250	8	a	a	PROPN
cajgh-4	250	9	,	,	PUNCT
cajgh-4	250	10	vukic	vukic	PROPN
cajgh-4	250	11	v	v	NOUN
cajgh-4	250	12	,	,	PUNCT
cajgh-4	250	13	xiong	xiong	PROPN
cajgh-4	250	14	h	h	PROPN
cajgh-4	250	15	,	,	PUNCT
cajgh-4	250	16	jones	jones	PROPN
cajgh-4	250	17	a	a	PROPN
cajgh-4	250	18	,	,	PUNCT
cajgh-4	250	19	et	et	PROPN
cajgh-4	250	20	al	al	PROPN
cajgh-4	250	21	.	.	PUNCT
cajgh-4	251	1	p4	p4	PROPN
cajgh-4	251	2	-	-	PUNCT
cajgh-4	251	3	182	182	NUM
cajgh-4	251	4	:	:	PUNCT
cajgh-4	251	5	inhibition	inhibition	NOUN
cajgh-4	251	6	of	of	ADP
cajgh-4	251	7	abcg2	abcg2	NOUN
cajgh-4	251	8	transport	transport	NOUN
cajgh-4	251	9	function	function	NOUN
cajgh-4	251	10	by	by	ADP
cajgh-4	251	11	amyloid	amyloid	NOUN
cajgh-4	251	12	-	-	PUNCT
cajgh-4	251	13	beta	beta	NOUN
cajgh-4	251	14	peptide	peptide	NOUN
cajgh-4	251	15	augments	augment	VERB
cajgh-4	251	16	cellular	cellular	ADJ
cajgh-4	251	17	oxidative	oxidative	ADJ
cajgh-4	251	18	stress	stress	NOUN
cajgh-4	251	19	and	and	CCONJ
cajgh-4	251	20	inflammatory	inflammatory	ADJ
cajgh-4	251	21	gene	gene	NOUN
cajgh-4	251	22	expression	expression	NOUN
cajgh-4	251	23	in	in	ADP
cajgh-4	251	24	cells	cell	NOUN
cajgh-4	251	25	.	.	PUNCT
cajgh-4	252	1	alzheimer	alzheimer	PROPN
cajgh-4	252	2	's	's	PART
cajgh-4	252	3	and	and	CCONJ
cajgh-4	252	4	dementia	dementia	NOUN
cajgh-4	252	5	.	.	PUNCT
cajgh-4	253	1	2008;4(4	2008;4(4	NUM
cajgh-4	253	2	,	,	PUNCT
cajgh-4	253	3	supplement	supplement	VERB
cajgh-4	253	4	1):t724	1):t724	NUM
cajgh-4	253	5	-	-	SYM
cajgh-4	253	6	t.	t.	NOUN
cajgh-4	253	7	54	54	NUM
cajgh-4	253	8	.	.	PUNCT
cajgh-4	254	1	park	park	PROPN
cajgh-4	254	2	l	l	PROPN
cajgh-4	254	3	,	,	PUNCT
cajgh-4	254	4	anrather	anrather	PROPN
cajgh-4	254	5	j	j	PROPN
cajgh-4	254	6	,	,	PUNCT
cajgh-4	254	7	zhou	zhou	PROPN
cajgh-4	254	8	p	p	PROPN
cajgh-4	254	9	,	,	PUNCT
cajgh-4	254	10	frys	frys	PROPN
cajgh-4	254	11	k	k	NOUN
cajgh-4	254	12	,	,	PUNCT
cajgh-4	254	13	pitstick	pitstick	NOUN
cajgh-4	254	14	r	r	NOUN
cajgh-4	254	15	,	,	PUNCT
cajgh-4	254	16	younkin	younkin	NOUN
cajgh-4	254	17	s	s	PROPN
cajgh-4	254	18	,	,	PUNCT
cajgh-4	254	19	et	et	PROPN
cajgh-4	254	20	al	al	PROPN
cajgh-4	254	21	.	.	PROPN
cajgh-4	254	22	nadph	nadph	PROPN
cajgh-4	254	23	oxidase	oxidase	NOUN
cajgh-4	254	24	-	-	PUNCT
cajgh-4	254	25	derived	derive	VERB
cajgh-4	254	26	reactive	reactive	ADJ
cajgh-4	254	27	oxygen	oxygen	NOUN
cajgh-4	254	28	species	specie	NOUN
cajgh-4	254	29	mediate	mediate	VERB
cajgh-4	254	30	the	the	DET
cajgh-4	254	31	cerebrovascular	cerebrovascular	ADJ
cajgh-4	254	32	dysfunction	dysfunction	NOUN
cajgh-4	254	33	induced	induce	VERB
cajgh-4	254	34	by	by	ADP
cajgh-4	254	35	the	the	DET
cajgh-4	254	36	amyloid	amyloid	NOUN
cajgh-4	254	37	{	{	PUNCT
cajgh-4	254	38	beta	beta	NOUN
cajgh-4	254	39	}	}	PUNCT
cajgh-4	254	40	peptide	peptide	NOUN
cajgh-4	254	41	.	.	PUNCT
cajgh-4	255	1	j	j	PROPN
cajgh-4	255	2	neurosci	neurosci	PROPN
cajgh-4	255	3	.	.	PUNCT
cajgh-4	256	1	2005;25(7):1769	2005;25(7):1769	NUM
cajgh-4	256	2	-	-	SYM
cajgh-4	256	3	77	77	NUM
cajgh-4	256	4	.	.	PUNCT
cajgh-4	257	1	55	55	NUM
cajgh-4	257	2	.	.	PUNCT
cajgh-4	258	1	park	park	PROPN
cajgh-4	258	2	l	l	PROPN
cajgh-4	258	3	,	,	PUNCT
cajgh-4	258	4	zhou	zhou	PROPN
cajgh-4	258	5	p	p	NOUN
cajgh-4	258	6	,	,	PUNCT
cajgh-4	258	7	pitstick	pitstick	NOUN
cajgh-4	258	8	r	r	NOUN
cajgh-4	258	9	,	,	PUNCT
cajgh-4	258	10	capone	capone	PROPN
cajgh-4	258	11	c	c	PROPN
cajgh-4	258	12	,	,	PUNCT
cajgh-4	258	13	anrather	anrather	PROPN
cajgh-4	258	14	j	j	PROPN
cajgh-4	258	15	,	,	PUNCT
cajgh-4	258	16	norris	norris	PROPN
cajgh-4	258	17	eh	eh	INTJ
cajgh-4	258	18	,	,	PUNCT
cajgh-4	258	19	et	et	PROPN
cajgh-4	258	20	al	al	PROPN
cajgh-4	258	21	.	.	PUNCT
cajgh-4	259	1	nox2	nox2	PROPN
cajgh-4	259	2	-	-	PUNCT
cajgh-4	259	3	derived	derive	VERB
cajgh-4	259	4	radicals	radical	NOUN
cajgh-4	259	5	contribute	contribute	VERB
cajgh-4	259	6	to	to	ADP
cajgh-4	259	7	neurovascular	neurovascular	ADJ
cajgh-4	259	8	and	and	CCONJ
cajgh-4	259	9	behavioral	behavioral	ADJ
cajgh-4	259	10	dysfunction	dysfunction	NOUN
cajgh-4	259	11	in	in	ADP
cajgh-4	259	12	mice	mouse	NOUN
cajgh-4	259	13	overexpressing	overexpresse	VERB
cajgh-4	259	14	the	the	DET
cajgh-4	259	15	amyloid	amyloid	NOUN
cajgh-4	259	16	precursor	precursor	NOUN
cajgh-4	259	17	protein	protein	NOUN
cajgh-4	259	18	.	.	PUNCT
cajgh-4	260	1	proceedings	proceeding	NOUN
cajgh-4	260	2	of	of	ADP
cajgh-4	260	3	the	the	DET
cajgh-4	260	4	national	national	PROPN
cajgh-4	260	5	academy	academy	PROPN
cajgh-4	260	6	of	of	ADP
cajgh-4	260	7	sciences	sciences	PROPN
cajgh-4	260	8	.	.	PUNCT
cajgh-4	261	1	2008;105(4):1347	2008;105(4):1347	NUM
cajgh-4	261	2	-	-	SYM
cajgh-4	261	3	52	52	NUM
cajgh-4	261	4	.	.	PUNCT
cajgh-4	262	1	56	56	NUM
cajgh-4	262	2	.	.	PUNCT
cajgh-4	263	1	cai	cai	PROPN
cajgh-4	263	2	h	h	PROPN
cajgh-4	263	3	,	,	PUNCT
cajgh-4	263	4	griendling	griendle	VERB
cajgh-4	263	5	kk	kk	PROPN
cajgh-4	263	6	,	,	PUNCT
cajgh-4	263	7	harrison	harrison	PROPN
cajgh-4	263	8	dg	dg	PROPN
cajgh-4	263	9	.	.	PUNCT
cajgh-4	264	1	the	the	DET
cajgh-4	264	2	vascular	vascular	ADJ
cajgh-4	264	3	nad(p)h	nad(p)h	NOUN
cajgh-4	264	4	oxidases	oxidase	NOUN
cajgh-4	264	5	as	as	ADP
cajgh-4	264	6	therapeutic	therapeutic	ADJ
cajgh-4	264	7	targets	target	NOUN
cajgh-4	264	8	in	in	ADP
cajgh-4	264	9	cardiovascular	cardiovascular	ADJ
cajgh-4	264	10	diseases	disease	NOUN
cajgh-4	264	11	.	.	PUNCT
cajgh-4	265	1	trends	trend	NOUN
cajgh-4	265	2	in	in	ADP
cajgh-4	265	3	pharmacological	pharmacological	ADJ
cajgh-4	265	4	sciences	science	NOUN
cajgh-4	265	5	.	.	PUNCT
cajgh-4	266	1	2003;24(9):471	2003;24(9):471	NUM
cajgh-4	266	2	-	-	PUNCT
cajgh-4	266	3	8	8	NUM
cajgh-4	266	4	.	.	PUNCT
cajgh-4	266	5	57	57	NUM
cajgh-4	266	6	.	.	PUNCT
cajgh-4	266	7	yan	yan	PROPN
cajgh-4	266	8	sd	sd	PROPN
cajgh-4	266	9	,	,	PUNCT
cajgh-4	266	10	chen	chen	PROPN
cajgh-4	266	11	x	x	PROPN
cajgh-4	266	12	,	,	PUNCT
cajgh-4	266	13	fu	fu	PROPN
cajgh-4	266	14	j	j	PROPN
cajgh-4	266	15	,	,	PUNCT
cajgh-4	266	16	chen	chen	PROPN
cajgh-4	266	17	m	m	PROPN
cajgh-4	266	18	,	,	PUNCT
cajgh-4	266	19	zhu	zhu	PROPN
cajgh-4	266	20	h	h	NOUN
cajgh-4	266	21	,	,	PUNCT
cajgh-4	266	22	roher	roher	ADV
cajgh-4	266	23	a	a	X
cajgh-4	266	24	,	,	PUNCT
cajgh-4	266	25	et	et	PROPN
cajgh-4	266	26	al	al	PROPN
cajgh-4	266	27	.	.	PROPN
cajgh-4	266	28	rage	rage	NOUN
cajgh-4	266	29	and	and	CCONJ
cajgh-4	266	30	amyloid-[beta	amyloid-[beta	PROPN
cajgh-4	266	31	]	]	X
cajgh-4	266	32	peptide	peptide	ADJ
cajgh-4	266	33	neurotoxicity	neurotoxicity	NOUN
cajgh-4	266	34	in	in	ADP
cajgh-4	266	35	alzheimer	alzheimer	PROPN
cajgh-4	266	36	's	's	PART
cajgh-4	266	37	disease	disease	NOUN
cajgh-4	266	38	.	.	PUNCT
cajgh-4	267	1	nature	nature	NOUN
cajgh-4	267	2	.	.	PUNCT
cajgh-4	268	1	1996;382(6593):685	1996;382(6593):685	NUM
cajgh-4	268	2	-	-	SYM
cajgh-4	268	3	91	91	NUM
cajgh-4	268	4	.	.	PUNCT
cajgh-4	269	1	58	58	NUM
cajgh-4	269	2	.	.	PUNCT
cajgh-4	270	1	arancio	arancio	PROPN
cajgh-4	270	2	o	o	PROPN
cajgh-4	270	3	,	,	PUNCT
cajgh-4	270	4	zhang	zhang	PROPN
cajgh-4	270	5	hp	hp	PROPN
cajgh-4	270	6	,	,	PUNCT
cajgh-4	270	7	chen	chen	PROPN
cajgh-4	270	8	x	x	PROPN
cajgh-4	270	9	,	,	PUNCT
cajgh-4	270	10	lin	lin	PROPN
cajgh-4	270	11	c	c	PROPN
cajgh-4	270	12	,	,	PUNCT
cajgh-4	270	13	trinchese	trinchese	PROPN
cajgh-4	270	14	f	f	NOUN
cajgh-4	270	15	,	,	PUNCT
cajgh-4	270	16	puzzo	puzzo	X
cajgh-4	270	17	d	d	NOUN
cajgh-4	270	18	,	,	PUNCT
cajgh-4	270	19	et	et	PROPN
cajgh-4	270	20	al	al	PROPN
cajgh-4	270	21	.	.	PROPN
cajgh-4	271	1	rage	rage	NOUN
cajgh-4	271	2	potentiates	potentiate	VERB
cajgh-4	271	3	a[beta]-induced	a[beta]-induce	VERB
cajgh-4	271	4	perturbation	perturbation	NOUN
cajgh-4	271	5	of	of	ADP
cajgh-4	271	6	neuronal	neuronal	ADJ
cajgh-4	271	7	function	function	NOUN
cajgh-4	271	8	in	in	ADP
cajgh-4	271	9	transgenic	transgenic	NOUN
cajgh-4	271	10	mice	mouse	NOUN
cajgh-4	271	11	.	.	PUNCT
cajgh-4	272	1	embo	embo	PROPN
cajgh-4	272	2	j.	j.	PROPN
cajgh-4	272	3	2004;23(20):4096	2004;23(20):4096	PROPN
cajgh-4	272	4	-	-	SYM
cajgh-4	272	5	105	105	NUM
cajgh-4	272	6	.	.	PUNCT
cajgh-4	272	7	59	59	NUM
cajgh-4	272	8	.	.	PUNCT
cajgh-4	273	1	chaney	chaney	PROPN
cajgh-4	273	2	mo	mo	PROPN
cajgh-4	273	3	,	,	PUNCT
cajgh-4	273	4	stine	stine	PROPN
cajgh-4	273	5	wb	wb	PROPN
cajgh-4	273	6	,	,	PUNCT
cajgh-4	273	7	kokjohn	kokjohn	PROPN
cajgh-4	273	8	ta	ta	PROPN
cajgh-4	273	9	,	,	PUNCT
cajgh-4	273	10	kuo	kuo	PROPN
cajgh-4	273	11	y	y	PROPN
cajgh-4	273	12	-	-	PUNCT
cajgh-4	273	13	m	m	PROPN
cajgh-4	273	14	,	,	PUNCT
cajgh-4	273	15	esh	esh	PROPN
cajgh-4	273	16	c	c	PROPN
cajgh-4	273	17	,	,	PUNCT
cajgh-4	273	18	rahman	rahman	PROPN
cajgh-4	273	19	a	a	PROPN
cajgh-4	273	20	,	,	PUNCT
cajgh-4	273	21	et	et	PROPN
cajgh-4	273	22	al	al	PROPN
cajgh-4	273	23	.	.	PROPN
cajgh-4	273	24	rage	rage	NOUN
cajgh-4	273	25	and	and	CCONJ
cajgh-4	273	26	amyloid	amyloid	VERB
cajgh-4	273	27	beta	beta	ADJ
cajgh-4	273	28	interactions	interaction	NOUN
cajgh-4	273	29	:	:	PUNCT
cajgh-4	273	30	atomic	atomic	ADJ
cajgh-4	273	31	force	force	NOUN
cajgh-4	273	32	microscopy	microscopy	NOUN
cajgh-4	273	33	and	and	CCONJ
cajgh-4	273	34	molecular	molecular	ADJ
cajgh-4	273	35	modeling	modeling	NOUN
cajgh-4	273	36	.	.	PUNCT
cajgh-4	274	1	biochimica	biochimica	PROPN
cajgh-4	274	2	et	et	PROPN
cajgh-4	274	3	biophysica	biophysica	PROPN
cajgh-4	274	4	acta	acta	PROPN
cajgh-4	274	5	(	(	PUNCT
cajgh-4	274	6	bba	bba	NOUN
cajgh-4	274	7	)	)	PUNCT
cajgh-4	274	8	molecular	molecular	ADJ
cajgh-4	274	9	basis	basis	NOUN
cajgh-4	274	10	of	of	ADP
cajgh-4	274	11	disease	disease	NOUN
cajgh-4	274	12	.	.	PUNCT
cajgh-4	275	1	2005;1741(1	2005;1741(1	NUM
cajgh-4	275	2	-	-	PUNCT
cajgh-4	275	3	2):199	2):199	NUM
cajgh-4	275	4	-	-	PUNCT
cajgh-4	275	5	205	205	NUM
cajgh-4	275	6	.	.	PUNCT
cajgh-4	276	1	60	60	NUM
cajgh-4	276	2	.	.	PUNCT
cajgh-4	277	1	sasaki	sasaki	PROPN
cajgh-4	277	2	n	n	CCONJ
cajgh-4	277	3	,	,	PUNCT
cajgh-4	277	4	toki	toki	PROPN
cajgh-4	277	5	s	s	PROPN
cajgh-4	277	6	,	,	PUNCT
cajgh-4	277	7	chowei	chowei	PROPN
cajgh-4	277	8	h	h	PROPN
cajgh-4	277	9	,	,	PUNCT
cajgh-4	277	10	saito	saito	PROPN
cajgh-4	277	11	t	t	PROPN
cajgh-4	277	12	,	,	PUNCT
cajgh-4	277	13	nakano	nakano	PROPN
cajgh-4	277	14	n	n	CCONJ
cajgh-4	277	15	,	,	PUNCT
cajgh-4	277	16	hayashi	hayashi	PROPN
cajgh-4	277	17	y	y	PROPN
cajgh-4	277	18	,	,	PUNCT
cajgh-4	277	19	et	et	PROPN
cajgh-4	277	20	al	al	PROPN
cajgh-4	277	21	.	.	PUNCT
cajgh-4	278	1	immunohistochemical	immunohistochemical	ADJ
cajgh-4	278	2	distribution	distribution	NOUN
cajgh-4	278	3	of	of	ADP
cajgh-4	278	4	the	the	DET
cajgh-4	278	5	receptor	receptor	NOUN
cajgh-4	278	6	for	for	ADP
cajgh-4	278	7	advanced	advanced	ADJ
cajgh-4	278	8	glycation	glycation	NOUN
cajgh-4	278	9	end	end	NOUN
cajgh-4	278	10	products	product	NOUN
cajgh-4	278	11	in	in	ADP
cajgh-4	278	12	neurons	neuron	NOUN
cajgh-4	278	13	and	and	CCONJ
cajgh-4	278	14	astrocytes	astrocyte	NOUN
cajgh-4	278	15	in	in	ADP
cajgh-4	278	16	alzheimer	alzheimer	PROPN
cajgh-4	278	17	's	's	PART
cajgh-4	278	18	disease	disease	NOUN
cajgh-4	278	19	.	.	PUNCT
cajgh-4	279	1	brain	brain	NOUN
cajgh-4	279	2	research	research	NOUN
cajgh-4	279	3	.	.	PUNCT
cajgh-4	280	1	2001;888(2):256	2001;888(2):256	NUM
cajgh-4	280	2	-	-	SYM
cajgh-4	280	3	62	62	NUM
cajgh-4	280	4	.	.	PUNCT
cajgh-4	281	1	61	61	NUM
cajgh-4	281	2	.	.	PUNCT
cajgh-4	282	1	lue	lue	PROPN
cajgh-4	282	2	l	l	PROPN
cajgh-4	282	3	-	-	PROPN
cajgh-4	282	4	f	f	PROPN
cajgh-4	282	5	,	,	PUNCT
cajgh-4	282	6	walker	walker	PROPN
cajgh-4	282	7	dg	dg	PROPN
cajgh-4	282	8	,	,	PUNCT
cajgh-4	282	9	brachova	brachova	PROPN
cajgh-4	282	10	l	l	PROPN
cajgh-4	282	11	,	,	PUNCT
cajgh-4	282	12	beach	beach	PROPN
cajgh-4	282	13	tg	tg	PROPN
cajgh-4	282	14	,	,	PUNCT
cajgh-4	282	15	rogers	rogers	PROPN
cajgh-4	282	16	j	j	PROPN
cajgh-4	282	17	,	,	PUNCT
cajgh-4	282	18	schmidt	schmidt	PROPN
cajgh-4	282	19	am	am	PROPN
cajgh-4	282	20	,	,	PUNCT
cajgh-4	282	21	et	et	PROPN
cajgh-4	282	22	al	al	PROPN
cajgh-4	282	23	.	.	PUNCT
cajgh-4	283	1	involvement	involvement	NOUN
cajgh-4	283	2	of	of	ADP
cajgh-4	283	3	microglial	microglial	ADJ
cajgh-4	283	4	receptor	receptor	NOUN
cajgh-4	283	5	for	for	ADP
cajgh-4	283	6	advanced	advanced	ADJ
cajgh-4	283	7	glycation	glycation	NOUN
cajgh-4	283	8	endproducts	endproduct	NOUN
cajgh-4	283	9	(	(	PUNCT
cajgh-4	283	10	rage	rage	NOUN
cajgh-4	283	11	)	)	PUNCT
cajgh-4	283	12	in	in	ADP
cajgh-4	283	13	alzheimer	alzheimer	PROPN
cajgh-4	283	14	's	's	PART
cajgh-4	283	15	disease	disease	NOUN
cajgh-4	283	16	:	:	PUNCT
cajgh-4	283	17	identification	identification	NOUN
cajgh-4	283	18	of	of	ADP
cajgh-4	283	19	a	a	DET
cajgh-4	283	20	cellular	cellular	ADJ
cajgh-4	283	21	activation	activation	NOUN
cajgh-4	283	22	mechanism	mechanism	NOUN
cajgh-4	283	23	.	.	PUNCT
cajgh-4	284	1	experimental	experimental	ADJ
cajgh-4	284	2	neurology	neurology	NOUN
cajgh-4	284	3	.	.	PUNCT
cajgh-4	285	1	2001;171(1):29	2001;171(1):29	NUM
cajgh-4	285	2	-	-	SYM
cajgh-4	285	3	45	45	NUM
cajgh-4	285	4	.	.	PUNCT
cajgh-4	286	1	62	62	NUM
cajgh-4	286	2	.	.	PUNCT
cajgh-4	287	1	askarova	askarova	PROPN
cajgh-4	287	2	s	s	PROPN
cajgh-4	287	3	,	,	PUNCT
cajgh-4	287	4	yang	yang	PROPN
cajgh-4	287	5	x	x	PROPN
cajgh-4	287	6	,	,	PUNCT
cajgh-4	287	7	sheng	sheng	PROPN
cajgh-4	287	8	w	w	PROPN
cajgh-4	287	9	,	,	PUNCT
cajgh-4	287	10	sun	sun	PROPN
cajgh-4	287	11	gy	gy	PROPN
cajgh-4	287	12	,	,	PUNCT
cajgh-4	287	13	lee	lee	PROPN
cajgh-4	287	14	jc	jc	PROPN
cajgh-4	287	15	-	-	PUNCT
cajgh-4	287	16	m.	m.	NOUN
cajgh-4	287	17	role	role	NOUN
cajgh-4	287	18	of	of	ADP
cajgh-4	287	19	ab	ab	NOUN
cajgh-4	287	20	-	-	NOUN
cajgh-4	287	21	receptor	receptor	NOUN
cajgh-4	287	22	for	for	ADP
cajgh-4	287	23	advanced	advanced	ADJ
cajgh-4	287	24	endproducts	endproduct	NOUN
cajgh-4	287	25	in	in	ADP
cajgh-4	287	26	oxidativestress	oxidativestress	NOUN
cajgh-4	287	27	and	and	CCONJ
cajgh-4	287	28	cytosolic	cytosolic	ADJ
cajgh-4	287	29	phospholipase	phospholipase	NOUN
cajgh-4	287	30	a2	a2	PROPN
cajgh-4	287	31	activation	activation	NOUN
cajgh-4	287	32	in	in	ADP
cajgh-4	287	33	astrocytes	astrocyte	NOUN
cajgh-4	287	34	and	and	CCONJ
cajgh-4	287	35	cerebral	cerebral	ADJ
cajgh-4	287	36	endothelial	endothelial	ADJ
cajgh-4	287	37	cells	cell	NOUN
cajgh-4	287	38	.	.	PUNCT
cajgh-4	288	1	neuroscience	neuroscience	NOUN
cajgh-4	288	2	.	.	PUNCT
cajgh-4	289	1	2011;199:375	2011;199:375	NUM
cajgh-4	289	2	-	-	SYM
cajgh-4	289	3	85	85	NUM
cajgh-4	289	4	.	.	PUNCT
cajgh-4	290	1	63	63	NUM
cajgh-4	290	2	.	.	PUNCT
cajgh-4	291	1	wautier	wauti	ADJ
cajgh-4	291	2	m	m	PROPN
cajgh-4	291	3	-	-	PUNCT
cajgh-4	291	4	p	p	X
cajgh-4	291	5	,	,	PUNCT
cajgh-4	291	6	chappey	chappey	NOUN
cajgh-4	291	7	o	o	NOUN
cajgh-4	291	8	,	,	PUNCT
cajgh-4	291	9	corda	corda	PROPN
cajgh-4	291	10	s	s	PART
cajgh-4	291	11	,	,	PUNCT
cajgh-4	291	12	stern	stern	ADJ
cajgh-4	291	13	dm	dm	PROPN
cajgh-4	291	14	,	,	PUNCT
cajgh-4	291	15	schmidt	schmidt	PROPN
cajgh-4	291	16	am	am	NOUN
cajgh-4	291	17	,	,	PUNCT
cajgh-4	291	18	wautier	wauti	ADJ
cajgh-4	291	19	j	j	PROPN
cajgh-4	291	20	-	-	PUNCT
cajgh-4	291	21	l.	l.	PROPN
cajgh-4	291	22	activation	activation	NOUN
cajgh-4	291	23	of	of	ADP
cajgh-4	291	24	nadph	nadph	ADJ
cajgh-4	291	25	oxidase	oxidase	NOUN
cajgh-4	291	26	by	by	ADP
cajgh-4	291	27	age	age	NOUN
cajgh-4	291	28	links	link	NOUN
cajgh-4	291	29	oxidant	oxidant	ADJ
cajgh-4	291	30	stress	stress	NOUN
cajgh-4	291	31	to	to	PART
cajgh-4	291	32	altered	alter	VERB
cajgh-4	291	33	gene	gene	NOUN
cajgh-4	291	34	expression	expression	NOUN
cajgh-4	291	35	via	via	ADP
cajgh-4	291	36	rage	rage	NOUN
cajgh-4	291	37	.	.	PUNCT
cajgh-4	292	1	am	be	AUX
cajgh-4	292	2	j	j	PROPN
cajgh-4	292	3	physiol	physiol	PROPN
cajgh-4	292	4	endocrinol	endocrinol	NOUN
cajgh-4	292	5	metab	metab	NOUN
cajgh-4	292	6	.	.	PUNCT
cajgh-4	293	1	2001;280(5):e685	2001;280(5):e685	NUM
cajgh-4	293	2	-	-	SYM
cajgh-4	293	3	94	94	NUM
cajgh-4	293	4	.	.	PUNCT
cajgh-4	294	1	64	64	NUM
cajgh-4	294	2	.	.	PUNCT
cajgh-4	295	1	giri	giri	PROPN
cajgh-4	295	2	r	r	PROPN
cajgh-4	295	3	,	,	PUNCT
cajgh-4	295	4	shen	shen	PROPN
cajgh-4	295	5	y	y	PROPN
cajgh-4	295	6	,	,	PUNCT
cajgh-4	295	7	stins	stin	VERB
cajgh-4	295	8	m	m	PROPN
cajgh-4	295	9	,	,	PUNCT
cajgh-4	295	10	du	du	PROPN
cajgh-4	295	11	yan	yan	PROPN
cajgh-4	295	12	s	s	PROPN
cajgh-4	295	13	,	,	PUNCT
cajgh-4	295	14	schmidt	schmidt	PROPN
cajgh-4	295	15	am	am	PROPN
cajgh-4	295	16	,	,	PUNCT
cajgh-4	295	17	stern	stern	PROPN
cajgh-4	295	18	d	d	PROPN
cajgh-4	295	19	,	,	PUNCT
cajgh-4	295	20	et	et	PROPN
cajgh-4	295	21	al	al	PROPN
cajgh-4	295	22	.	.	PUNCT
cajgh-4	296	1	beta	beta	NOUN
cajgh-4	296	2	-	-	PUNCT
cajgh-4	296	3	amyloid	amyloid	NOUN
cajgh-4	296	4	-	-	PUNCT
cajgh-4	296	5	induced	induce	VERB
cajgh-4	296	6	migration	migration	NOUN
cajgh-4	296	7	of	of	ADP
cajgh-4	296	8	monocytes	monocyte	NOUN
cajgh-4	296	9	across	across	ADP
cajgh-4	296	10	human	human	ADJ
cajgh-4	296	11	brain	brain	NOUN
cajgh-4	296	12	endothelial	endothelial	NOUN
cajgh-4	296	13	cells	cell	NOUN
cajgh-4	296	14	involves	involve	VERB
cajgh-4	296	15	rage	rage	NOUN
cajgh-4	296	16	and	and	CCONJ
cajgh-4	296	17	pecam-1	pecam-1	NUM
cajgh-4	296	18	.	.	PUNCT
cajgh-4	296	19	am	be	AUX
cajgh-4	296	20	j	j	PROPN
cajgh-4	296	21	physiol	physiol	PROPN
cajgh-4	296	22	cell	cell	PROPN
cajgh-4	296	23	physiol	physiol	PROPN
cajgh-4	296	24	.	.	PUNCT
cajgh-4	297	1	2000;279(6):c1772	2000;279(6):c1772	NUM
cajgh-4	297	2	-	-	SYM
cajgh-4	297	3	81	81	NUM
cajgh-4	297	4	.	.	PUNCT
cajgh-4	298	1	65	65	NUM
cajgh-4	298	2	.	.	PUNCT
cajgh-4	299	1	takuma	takuma	PROPN
cajgh-4	299	2	k	k	PROPN
cajgh-4	299	3	,	,	PUNCT
cajgh-4	299	4	fang	fang	PROPN
cajgh-4	299	5	f	f	PROPN
cajgh-4	299	6	,	,	PUNCT
cajgh-4	299	7	zhang	zhang	PROPN
cajgh-4	299	8	w	w	PROPN
cajgh-4	299	9	,	,	PUNCT
cajgh-4	299	10	yan	yan	PROPN
cajgh-4	299	11	s	s	PART
cajgh-4	299	12	,	,	PUNCT
cajgh-4	299	13	fukuzaki	fukuzaki	PROPN
cajgh-4	299	14	e	e	NOUN
cajgh-4	299	15	,	,	PUNCT
cajgh-4	299	16	du	du	PROPN
cajgh-4	299	17	h	h	PROPN
cajgh-4	299	18	,	,	PUNCT
cajgh-4	299	19	et	et	PROPN
cajgh-4	299	20	al	al	PROPN
cajgh-4	299	21	.	.	PUNCT
cajgh-4	299	22	rage	rage	NOUN
cajgh-4	299	23	-	-	PUNCT
cajgh-4	299	24	mediated	mediate	VERB
cajgh-4	299	25	signaling	signaling	NOUN
cajgh-4	299	26	contributes	contribute	VERB
cajgh-4	299	27	to	to	ADP
cajgh-4	299	28	intraneuronal	intraneuronal	ADJ
cajgh-4	299	29	transport	transport	NOUN
cajgh-4	299	30	of	of	ADP
cajgh-4	299	31	amyloid	amyloid	NOUN
cajgh-4	299	32	-	-	PUNCT
cajgh-4	299	33	оі	оі	NOUN
cajgh-4	299	34	and	and	CCONJ
cajgh-4	299	35	neuronal	neuronal	ADJ
cajgh-4	299	36	dysfunction	dysfunction	NOUN
cajgh-4	299	37	.	.	PUNCT
cajgh-4	300	1	proceedings	proceeding	NOUN
cajgh-4	300	2	of	of	ADP
cajgh-4	300	3	the	the	DET
cajgh-4	300	4	national	national	PROPN
cajgh-4	300	5	academy	academy	PROPN
cajgh-4	300	6	of	of	ADP
cajgh-4	300	7	sciences	sciences	PROPN
cajgh-4	300	8	.	.	PUNCT
cajgh-4	301	1	2009;106(47):20021	2009;106(47):20021	NUM
cajgh-4	301	2	-	-	SYM
cajgh-4	301	3	6	6	NUM
cajgh-4	301	4	.	.	PUNCT
cajgh-4	301	5	66	66	NUM
cajgh-4	301	6	.	.	PUNCT
cajgh-4	302	1	zhu	zhu	PROPN
cajgh-4	302	2	d	d	PROPN
cajgh-4	302	3	,	,	PUNCT
cajgh-4	302	4	lai	lai	PROPN
cajgh-4	302	5	y	y	PROPN
cajgh-4	302	6	,	,	PUNCT
cajgh-4	302	7	shelat	shelat	NOUN
cajgh-4	302	8	pb	pb	PROPN
cajgh-4	302	9	,	,	PUNCT
cajgh-4	302	10	hu	hu	PROPN
cajgh-4	302	11	c	c	PROPN
cajgh-4	302	12	,	,	PUNCT
cajgh-4	302	13	sun	sun	PROPN
cajgh-4	302	14	gy	gy	PROPN
cajgh-4	302	15	,	,	PUNCT
cajgh-4	302	16	lee	lee	PROPN
cajgh-4	302	17	jcm	jcm	PROPN
cajgh-4	302	18	.	.	PROPN
cajgh-4	302	19	phospholipases	phospholipases	PROPN
cajgh-4	302	20	a2	a2	PROPN
cajgh-4	302	21	mediate	mediate	VERB
cajgh-4	302	22	amyloid	amyloid	NOUN
cajgh-4	302	23	-	-	PUNCT
cajgh-4	302	24	beta	beta	NOUN
cajgh-4	302	25	peptide	peptide	NOUN
cajgh-4	302	26	-	-	PUNCT
cajgh-4	302	27	induced	induce	VERB
cajgh-4	302	28	mitochondrial	mitochondrial	ADJ
cajgh-4	302	29	dysfunction	dysfunction	NOUN
cajgh-4	302	30	.	.	PUNCT
cajgh-4	303	1	j	j	PROPN
cajgh-4	303	2	neurosci	neurosci	PROPN
cajgh-4	303	3	.	.	PUNCT
cajgh-4	304	1	2006;26(43):11111	2006;26(43):11111	X
cajgh-4	304	2	-	-	SYM
cajgh-4	304	3	9	9	NUM
cajgh-4	304	4	.	.	NOUN
cajgh-4	304	5	67	67	NUM
cajgh-4	304	6	.	.	PUNCT
cajgh-4	305	1	stephenson	stephenson	PROPN
cajgh-4	305	2	dt	dt	PROPN
cajgh-4	305	3	,	,	PUNCT
cajgh-4	305	4	lemere	lemere	PROPN
cajgh-4	305	5	ca	can	AUX
cajgh-4	305	6	,	,	PUNCT
cajgh-4	305	7	selkoe	selkoe	ADJ
cajgh-4	305	8	dj	dj	NOUN
cajgh-4	305	9	,	,	PUNCT
cajgh-4	305	10	clemens	clemens	PROPN
cajgh-4	305	11	ja	ja	PROPN
cajgh-4	305	12	.	.	PUNCT
cajgh-4	305	13	cytosolic	cytosolic	PROPN
cajgh-4	305	14	phospholipase	phospholipase	PROPN
cajgh-4	305	15	a2	a2	PROPN
cajgh-4	305	16	(	(	PUNCT
cajgh-4	305	17	cpla2	cpla2	PROPN
cajgh-4	305	18	)	)	PUNCT
cajgh-4	305	19	immunoreactivity	immunoreactivity	NOUN
cajgh-4	305	20	is	be	AUX
cajgh-4	305	21	elevated	elevate	VERB
cajgh-4	305	22	in	in	ADP
cajgh-4	305	23	alzheimer	alzheimer	PROPN
cajgh-4	305	24	's	's	PART
cajgh-4	305	25	disease	disease	NOUN
cajgh-4	305	26	brain	brain	NOUN
cajgh-4	305	27	.	.	PUNCT
cajgh-4	306	1	neurobiol	neurobiol	PROPN
cajgh-4	306	2	dis	dis	PROPN
cajgh-4	306	3	.	.	PUNCT
cajgh-4	307	1	1996;3(1):51	1996;3(1):51	NUM
cajgh-4	307	2	-	-	SYM
cajgh-4	307	3	63	63	NUM
cajgh-4	307	4	.	.	PUNCT
cajgh-4	308	1	epub	epub	NOUN
cajgh-4	308	2	1996/02/01	1996/02/01	NOUN
cajgh-4	308	3	.	.	PUNCT
cajgh-4	309	1	68	68	NUM
cajgh-4	309	2	.	.	PUNCT
cajgh-4	310	1	moses	moses	PROPN
cajgh-4	310	2	gs	gs	PROPN
cajgh-4	310	3	,	,	PUNCT
cajgh-4	310	4	jensen	jensen	PROPN
cajgh-4	310	5	md	md	PROPN
cajgh-4	310	6	,	,	PUNCT
cajgh-4	310	7	lue	lue	PROPN
cajgh-4	310	8	lf	lf	PROPN
cajgh-4	310	9	,	,	PUNCT
cajgh-4	310	10	walker	walker	PROPN
cajgh-4	310	11	dg	dg	PROPN
cajgh-4	310	12	,	,	PUNCT
cajgh-4	310	13	sun	sun	PROPN
cajgh-4	310	14	ay	ay	PROPN
cajgh-4	310	15	,	,	PUNCT
cajgh-4	310	16	simonyi	simonyi	NOUN
cajgh-4	310	17	a	a	X
cajgh-4	310	18	,	,	PUNCT
cajgh-4	310	19	et	et	PROPN
cajgh-4	310	20	al	al	PROPN
cajgh-4	310	21	.	.	PUNCT
cajgh-4	310	22	secretory	secretory	PROPN
cajgh-4	310	23	pla2	pla2	PROPN
cajgh-4	310	24	-	-	PUNCT
cajgh-4	310	25	iia	iia	PROPN
cajgh-4	310	26	:	:	PUNCT
cajgh-4	310	27	a	a	DET
cajgh-4	310	28	new	new	ADJ
cajgh-4	310	29	inflammatory	inflammatory	ADJ
cajgh-4	310	30	factor	factor	NOUN
cajgh-4	310	31	for	for	ADP
cajgh-4	310	32	alzheimer	alzheimer	PROPN
cajgh-4	310	33	's	's	PART
cajgh-4	310	34	disease	disease	NOUN
cajgh-4	310	35	.	.	PUNCT
cajgh-4	311	1	j	j	PROPN
cajgh-4	311	2	neuroinflammation	neuroinflammation	PROPN
cajgh-4	311	3	.	.	PUNCT
cajgh-4	312	1	2006;3:28	2006;3:28	NOUN
cajgh-4	312	2	.	.	PUNCT
cajgh-4	313	1	epub	epub	NOUN
cajgh-4	313	2	2006/10/10	2006/10/10	NUM
cajgh-4	313	3	.	.	PUNCT
cajgh-4	314	1	69	69	NUM
cajgh-4	314	2	.	.	PUNCT
cajgh-4	315	1	dineley	dineley	PROPN
cajgh-4	315	2	kt	kt	PROPN
cajgh-4	315	3	,	,	PUNCT
cajgh-4	315	4	westerman	westerman	PROPN
cajgh-4	315	5	m	m	PROPN
cajgh-4	315	6	,	,	PUNCT
cajgh-4	315	7	bui	bui	PROPN
cajgh-4	315	8	d	d	NOUN
cajgh-4	315	9	,	,	PUNCT
cajgh-4	315	10	bell	bell	PROPN
cajgh-4	315	11	k	k	PROPN
cajgh-4	315	12	,	,	PUNCT
cajgh-4	315	13	ashe	ashe	PROPN
cajgh-4	315	14	kh	kh	PROPN
cajgh-4	315	15	,	,	PUNCT
cajgh-4	315	16	sweatt	sweatt	PROPN
cajgh-4	315	17	jd	jd	PROPN
cajgh-4	315	18	.	.	PUNCT
cajgh-4	315	19	{	{	PUNCT
cajgh-4	316	1	beta}-amyloid	beta}-amyloid	PROPN
cajgh-4	316	2	activates	activate	VERB
cajgh-4	316	3	the	the	DET
cajgh-4	316	4	mitogen	mitogen	NOUN
cajgh-4	316	5	-	-	PUNCT
cajgh-4	316	6	activated	activate	VERB
cajgh-4	316	7	protein	protein	NOUN
cajgh-4	316	8	kinase	kinase	NOUN
cajgh-4	316	9	cascade	cascade	NOUN
cajgh-4	316	10	via	via	ADP
cajgh-4	316	11	hippocampal	hippocampal	ADJ
cajgh-4	316	12	{	{	PUNCT
cajgh-4	316	13	alpha}7	alpha}7	NOUN
cajgh-4	316	14	nicotinic	nicotinic	ADJ
cajgh-4	316	15	acetylcholine	acetylcholine	NOUN
cajgh-4	316	16	receptors	receptor	NOUN
cajgh-4	316	17	:	:	PUNCT
cajgh-4	316	18	in	in	ADP
cajgh-4	316	19	vitro	vitro	X
cajgh-4	316	20	and	and	CCONJ
cajgh-4	316	21	in	in	ADP
cajgh-4	316	22	vivo	vivo	ADJ
cajgh-4	316	23	mechanisms	mechanism	NOUN
cajgh-4	316	24	related	relate	VERB
cajgh-4	316	25	to	to	ADP
cajgh-4	316	26	alzheimer	alzheimer	PROPN
cajgh-4	316	27	's	's	PART
cajgh-4	316	28	disease	disease	NOUN
cajgh-4	316	29	.	.	PUNCT
cajgh-4	317	1	j	j	PROPN
cajgh-4	317	2	neurosci	neurosci	PROPN
cajgh-4	317	3	.	.	PUNCT
cajgh-4	318	1	2001;21(12):4125	2001;21(12):4125	NUM
cajgh-4	318	2	-	-	SYM
cajgh-4	318	3	33	33	NUM
cajgh-4	318	4	.	.	PUNCT
cajgh-4	319	1	70	70	NUM
cajgh-4	319	2	.	.	PUNCT
cajgh-4	320	1	young	young	ADJ
cajgh-4	320	2	kf	kf	PROPN
cajgh-4	320	3	,	,	PUNCT
cajgh-4	320	4	pasternak	pasternak	PROPN
cajgh-4	320	5	sh	sh	PROPN
cajgh-4	320	6	,	,	PUNCT
cajgh-4	320	7	rylett	rylett	PROPN
cajgh-4	320	8	rj	rj	PROPN
cajgh-4	320	9	.	.	PROPN
cajgh-4	320	10	oligomeric	oligomeric	ADJ
cajgh-4	320	11	aggregates	aggregate	NOUN
cajgh-4	320	12	of	of	ADP
cajgh-4	320	13	amyloid	amyloid	NOUN
cajgh-4	320	14	[	[	X
cajgh-4	320	15	beta	beta	NOUN
cajgh-4	320	16	]	]	PUNCT
cajgh-4	320	17	peptide	peptide	NOUN
cajgh-4	320	18	1	1	NUM
cajgh-4	320	19	-	-	SYM
cajgh-4	320	20	42	42	NUM
cajgh-4	320	21	activate	activate	VERB
cajgh-4	320	22	erk	erk	PROPN
cajgh-4	320	23	/	/	SYM
cajgh-4	320	24	mapk	mapk	NOUN
cajgh-4	320	25	in	in	ADP
cajgh-4	320	26	sh	sh	PROPN
cajgh-4	320	27	-	-	PUNCT
cajgh-4	320	28	sy5y	sy5y	PROPN
cajgh-4	320	29	cells	cell	NOUN
cajgh-4	320	30	via	via	ADP
cajgh-4	320	31	the	the	DET
cajgh-4	320	32	[	[	X
cajgh-4	320	33	alpha]7	alpha]7	NOUN
cajgh-4	320	34	nicotinic	nicotinic	ADJ
cajgh-4	320	35	receptor	receptor	NOUN
cajgh-4	320	36	.	.	PUNCT
cajgh-4	321	1	neurochemistry	neurochemistry	PROPN
cajgh-4	321	2	international	international	PROPN
cajgh-4	321	3	.	.	PUNCT
cajgh-4	322	1	2009;55(8):796	2009;55(8):796	NUM
cajgh-4	322	2	-	-	SYM
cajgh-4	322	3	801	801	NUM
cajgh-4	322	4	.	.	PUNCT
cajgh-4	323	1	71	71	NUM
cajgh-4	323	2	.	.	PUNCT
cajgh-4	323	3	mcdonald	mcdonald	PROPN
cajgh-4	323	4	dr	dr	PROPN
cajgh-4	323	5	,	,	PUNCT
cajgh-4	323	6	bamberger	bamberger	VERB
cajgh-4	323	7	me	i	PRON
cajgh-4	323	8	,	,	PUNCT
cajgh-4	323	9	combs	comb	VERB
cajgh-4	323	10	ck	ck	PROPN
cajgh-4	323	11	,	,	PUNCT
cajgh-4	323	12	landreth	landreth	PROPN
cajgh-4	323	13	ge	ge	PROPN
cajgh-4	323	14	.	.	PUNCT
cajgh-4	324	1	beta	beta	ADJ
cajgh-4	324	2	-amyloid	-amyloid	PROPN
cajgh-4	324	3	fibrils	fibril	NOUN
cajgh-4	324	4	activate	activate	VERB
cajgh-4	324	5	parallel	parallel	ADJ
cajgh-4	324	6	mitogen	mitogen	NOUN
cajgh-4	324	7	-	-	PUNCT
cajgh-4	324	8	activated	activate	VERB
cajgh-4	324	9	protein	protein	NOUN
cajgh-4	324	10	kinase	kinase	NOUN
cajgh-4	324	11	pathways	pathway	NOUN
cajgh-4	324	12	in	in	ADP
cajgh-4	324	13	microglia	microglia	ADJ
cajgh-4	324	14	and	and	CCONJ
cajgh-4	324	15	thp1	thp1	NOUN
cajgh-4	324	16	monocytes	monocyte	NOUN
cajgh-4	324	17	.	.	PUNCT
cajgh-4	325	1	j	j	PROPN
cajgh-4	325	2	neurosci	neurosci	PROPN
cajgh-4	325	3	.	.	PUNCT
cajgh-4	326	1	1998;18(12):4451	1998;18(12):4451	NUM
cajgh-4	326	2	-	-	SYM
cajgh-4	326	3	60	60	NUM
cajgh-4	326	4	.	.	PUNCT
cajgh-4	327	1	72	72	NUM
cajgh-4	327	2	.	.	PUNCT
cajgh-4	328	1	shelat	shelat	NOUN
cajgh-4	328	2	p	p	PROPN
cajgh-4	328	3	,	,	PUNCT
cajgh-4	328	4	b.	b.	PROPN
cajgh-4	328	5	,	,	PUNCT
cajgh-4	328	6	chalimoniuk	chalimoniuk	PROPN
cajgh-4	328	7	m	m	PROPN
cajgh-4	328	8	,	,	PUNCT
cajgh-4	328	9	wang	wang	PROPN
cajgh-4	328	10	j	j	PROPN
cajgh-4	328	11	-	-	PROPN
cajgh-4	328	12	h	h	PROPN
cajgh-4	328	13	,	,	PUNCT
cajgh-4	328	14	strosznajder	strosznajder	VERB
cajgh-4	328	15	j	j	PROPN
cajgh-4	328	16	,	,	PUNCT
cajgh-4	328	17	b.	b.	PROPN
cajgh-4	328	18	,	,	PUNCT
cajgh-4	328	19	lee	lee	PROPN
cajgh-4	328	20	j	j	PROPN
cajgh-4	328	21	,	,	PUNCT
cajgh-4	328	22	c.	c.	PROPN
cajgh-4	328	23	,	,	PUNCT
cajgh-4	328	24	sun	sun	PROPN
cajgh-4	328	25	a	a	PRON
cajgh-4	328	26	,	,	PUNCT
cajgh-4	328	27	y.	y.	PROPN
cajgh-4	328	28	,	,	PUNCT
cajgh-4	328	29	et	et	PROPN
cajgh-4	328	30	al	al	PROPN
cajgh-4	328	31	.	.	PUNCT
cajgh-4	328	32	amyloid	amyloid	PROPN
cajgh-4	328	33	beta	beta	ADJ
cajgh-4	328	34	peptide	peptide	NOUN
cajgh-4	328	35	and	and	CCONJ
cajgh-4	328	36	nmda	nmda	ADJ
cajgh-4	328	37	induce	induce	VERB
cajgh-4	328	38	ros	ros	PROPN
cajgh-4	328	39	from	from	ADP
cajgh-4	328	40	nadph	nadph	ADJ
cajgh-4	328	41	oxidase	oxidase	NOUN
cajgh-4	328	42	and	and	CCONJ
cajgh-4	328	43	aa	aa	NOUN
cajgh-4	328	44	release	release	NOUN
cajgh-4	328	45	from	from	ADP
cajgh-4	328	46	cytosolic	cytosolic	ADJ
cajgh-4	328	47	phospholipase	phospholipase	NOUN
cajgh-4	328	48	a2	a2	PROPN
cajgh-4	328	49	in	in	ADP
cajgh-4	328	50	cortical	cortical	ADJ
cajgh-4	328	51	neurons	neuron	NOUN
cajgh-4	328	52	.	.	PUNCT
cajgh-4	329	1	journal	journal	NOUN
cajgh-4	329	2	of	of	ADP
cajgh-4	329	3	neurochemistry	neurochemistry	NOUN
cajgh-4	329	4	.	.	PUNCT
cajgh-4	330	1	2008;106(1):45	2008;106(1):45	NUM
cajgh-4	330	2	-	-	SYM
cajgh-4	330	3	55	55	NUM
cajgh-4	330	4	.	.	PUNCT
cajgh-4	331	1	73	73	NUM
cajgh-4	331	2	.	.	PUNCT
cajgh-4	332	1	stephenson	stephenson	PROPN
cajgh-4	332	2	d	d	PROPN
cajgh-4	332	3	,	,	PUNCT
cajgh-4	332	4	rash	rash	ADJ
cajgh-4	332	5	k	k	NOUN
cajgh-4	332	6	,	,	PUNCT
cajgh-4	332	7	smalstig	smalstig	PROPN
cajgh-4	332	8	b	b	PROPN
cajgh-4	332	9	,	,	PUNCT
cajgh-4	332	10	roberts	roberts	PROPN
cajgh-4	332	11	e	e	PROPN
cajgh-4	332	12	,	,	PUNCT
cajgh-4	332	13	johnstone	johnstone	PROPN
cajgh-4	332	14	e	e	PROPN
cajgh-4	332	15	,	,	PUNCT
cajgh-4	332	16	sharp	sharp	PROPN
cajgh-4	332	17	j	j	PROPN
cajgh-4	332	18	,	,	PUNCT
cajgh-4	332	19	et	et	PROPN
cajgh-4	332	20	al	al	PROPN
cajgh-4	332	21	.	.	PROPN
cajgh-4	332	22	cytosolic	cytosolic	PROPN
cajgh-4	332	23	phospholipase	phospholipase	PROPN
cajgh-4	332	24	a2	a2	PROPN
cajgh-4	332	25	is	be	AUX
cajgh-4	332	26	induced	induce	VERB
cajgh-4	332	27	in	in	ADP
cajgh-4	332	28	reactive	reactive	ADJ
cajgh-4	332	29	glia	glia	NOUN
cajgh-4	332	30	following	follow	VERB
cajgh-4	332	31	different	different	ADJ
cajgh-4	332	32	forms	form	NOUN
cajgh-4	332	33	of	of	ADP
cajgh-4	332	34	neurodegeneration	neurodegeneration	NOUN
cajgh-4	332	35	.	.	PUNCT
cajgh-4	333	1	glia	glia	NOUN
cajgh-4	333	2	.	.	PUNCT
cajgh-4	334	1	1999;27(2):110	1999;27(2):110	NUM
cajgh-4	334	2	-	-	SYM
cajgh-4	334	3	28	28	NUM
cajgh-4	334	4	.	.	PUNCT
cajgh-4	335	1	epub	epub	NOUN
cajgh-4	335	2	1999/07/27	1999/07/27	PROPN
cajgh-4	335	3	.	.	PUNCT
cajgh-4	336	1	74	74	NUM
cajgh-4	336	2	.	.	PUNCT
cajgh-4	337	1	sun	sun	PROPN
cajgh-4	337	2	gy	gy	PROPN
cajgh-4	337	3	,	,	PUNCT
cajgh-4	337	4	horrocks	horrock	VERB
cajgh-4	337	5	la	la	PROPN
cajgh-4	337	6	,	,	PUNCT
cajgh-4	337	7	farooqui	farooqui	NOUN
cajgh-4	337	8	aa	aa	NOUN
cajgh-4	337	9	.	.	PUNCT
cajgh-4	338	1	the	the	DET
cajgh-4	338	2	roles	role	NOUN
cajgh-4	338	3	of	of	ADP
cajgh-4	338	4	nadph	nadph	ADJ
cajgh-4	338	5	oxidase	oxidase	NOUN
cajgh-4	338	6	and	and	CCONJ
cajgh-4	338	7	phospholipases	phospholipase	NOUN
cajgh-4	338	8	a2	a2	PROPN
cajgh-4	338	9	in	in	ADP
cajgh-4	338	10	oxidative	oxidative	ADJ
cajgh-4	338	11	and	and	CCONJ
cajgh-4	338	12	inflammatory	inflammatory	ADJ
cajgh-4	338	13	responses	response	NOUN
cajgh-4	338	14	in	in	ADP
cajgh-4	338	15	neurodegenerative	neurodegenerative	ADJ
cajgh-4	338	16	diseases	disease	NOUN
cajgh-4	338	17	.	.	PUNCT
cajgh-4	339	1	journal	journal	NOUN
cajgh-4	339	2	of	of	ADP
cajgh-4	339	3	neurochemistry	neurochemistry	NOUN
cajgh-4	339	4	.	.	PUNCT
cajgh-4	340	1	2007;103(1):1	2007;103(1):1	NUM
cajgh-4	340	2	-	-	SYM
cajgh-4	340	3	16	16	NUM
cajgh-4	340	4	.	.	PUNCT
cajgh-4	341	1	75	75	NUM
cajgh-4	341	2	.	.	PUNCT
cajgh-4	342	1	maat	maat	NOUN
cajgh-4	342	2	-	-	PUNCT
cajgh-4	342	3	schieman	schieman	NOUN
cajgh-4	342	4	ml	ml	NOUN
cajgh-4	342	5	vds	vds	PROPN
cajgh-4	342	6	,	,	PUNCT
cajgh-4	342	7	rozemuller	rozemuller	NOUN
cajgh-4	342	8	aj	aj	PROPN
cajgh-4	342	9	,	,	PUNCT
cajgh-4	342	10	haan	haan	PROPN
cajgh-4	342	11	j	j	PROPN
cajgh-4	342	12	,	,	PUNCT
cajgh-4	342	13	roos	roos	PROPN
cajgh-4	342	14	ra	ra	PROPN
cajgh-4	342	15	.	.	PROPN
cajgh-4	342	16	association	association	PROPN
cajgh-4	342	17	of	of	ADP
cajgh-4	342	18	vascular	vascular	ADJ
cajgh-4	342	19	amyloid	amyloid	NOUN
cajgh-4	342	20	beta	beta	NOUN
cajgh-4	342	21	and	and	CCONJ
cajgh-4	342	22	cells	cell	NOUN
cajgh-4	342	23	of	of	ADP
cajgh-4	342	24	the	the	DET
cajgh-4	342	25	mononuclear	mononuclear	ADJ
cajgh-4	342	26	phagocyte	phagocyte	NOUN
cajgh-4	342	27	system	system	NOUN
cajgh-4	342	28	in	in	ADP
cajgh-4	342	29	hereditary	hereditary	ADJ
cajgh-4	342	30	cerebral	cerebral	ADJ
cajgh-4	342	31	hemorrhage	hemorrhage	NOUN
cajgh-4	342	32	with	with	ADP
cajgh-4	342	33	amyloidosis	amyloidosis	NOUN
cajgh-4	342	34	(	(	PUNCT
cajgh-4	342	35	dutch	dutch	NOUN
cajgh-4	342	36	)	)	PUNCT
cajgh-4	342	37	and	and	CCONJ
cajgh-4	342	38	alzheimer	alzheimer	PROPN
cajgh-4	342	39	disease	disease	NOUN
cajgh-4	342	40	.	.	PUNCT
cajgh-4	343	1	j	j	PROPN
cajgh-4	343	2	neuropathol	neuropathol	PROPN
cajgh-4	343	3	exp	exp	PROPN
cajgh-4	343	4	neurol	neurol	PROPN
cajgh-4	343	5	.	.	PUNCT
cajgh-4	344	1	1997(56):273	1997(56):273	NUM
cajgh-4	344	2	-	-	SYM
cajgh-4	344	3	84	84	NUM
cajgh-4	344	4	.	.	PUNCT
cajgh-4	345	1	76	76	NUM
cajgh-4	345	2	.	.	PUNCT
cajgh-4	346	1	uchihara	uchihara	PROPN
cajgh-4	346	2	t	t	PROPN
cajgh-4	346	3	ah	ah	INTJ
cajgh-4	346	4	,	,	PUNCT
cajgh-4	346	5	kondo	kondo	PROPN
cajgh-4	346	6	h	h	PROPN
cajgh-4	346	7	,	,	PUNCT
cajgh-4	346	8	ikeda	ikeda	PROPN
cajgh-4	346	9	k.	k.	PROPN
cajgh-4	346	10	activated	activate	VERB
cajgh-4	346	11	microglial	microglial	ADJ
cajgh-4	346	12	cells	cell	NOUN
cajgh-4	346	13	are	be	AUX
cajgh-4	346	14	colocalized	colocalize	VERB
cajgh-4	346	15	with	with	ADP
cajgh-4	346	16	perivascular	perivascular	ADJ
cajgh-4	346	17	deposits	deposit	NOUN
cajgh-4	346	18	of	of	ADP
cajgh-4	346	19	amyloid	amyloid	NOUN
cajgh-4	346	20	-	-	PUNCT
cajgh-4	346	21	beta	beta	NOUN
cajgh-4	346	22	protein	protein	NOUN
cajgh-4	346	23	in	in	ADP
cajgh-4	346	24	alzheimer	alzheimer	PROPN
cajgh-4	346	25	's	's	PART
cajgh-4	346	26	disease	disease	NOUN
cajgh-4	346	27	brain	brain	NOUN
cajgh-4	346	28	.	.	PUNCT
cajgh-4	347	1	stroke	stroke	NOUN
cajgh-4	347	2	.	.	PUNCT
cajgh-4	348	1	1997(28):1948	1997(28):1948	NUM
cajgh-4	348	2	-	-	SYM
cajgh-4	348	3	50	50	NUM
cajgh-4	348	4	.	.	PUNCT
cajgh-4	349	1	77	77	NUM
cajgh-4	349	2	.	.	PUNCT
cajgh-4	350	1	selkoe	selkoe	PROPN
cajgh-4	350	2	dj	dj	PROPN
cajgh-4	350	3	,	,	PUNCT
cajgh-4	350	4	schenk	schenk	PROPN
cajgh-4	350	5	d.	d.	PROPN
cajgh-4	350	6	alzheimer	alzheimer	PROPN
cajgh-4	350	7	's	's	PART
cajgh-4	350	8	disease	disease	NOUN
cajgh-4	350	9	:	:	PUNCT
cajgh-4	350	10	molecular	molecular	ADJ
cajgh-4	350	11	understanding	understanding	NOUN
cajgh-4	350	12	predicts	predict	VERB
cajgh-4	350	13	amyloid	amyloid	NOUN
cajgh-4	350	14	-	-	PUNCT
cajgh-4	350	15	based	base	VERB
cajgh-4	350	16	therapeutics	therapeutic	NOUN
cajgh-4	350	17	.	.	PUNCT
cajgh-4	351	1	annual	annual	ADJ
cajgh-4	351	2	review	review	NOUN
cajgh-4	351	3	of	of	ADP
cajgh-4	351	4	pharmacology	pharmacology	NOUN
cajgh-4	351	5	and	and	CCONJ
cajgh-4	351	6	toxicology	toxicology	NOUN
cajgh-4	351	7	.	.	PUNCT
cajgh-4	352	1	2003;43(1):545	2003;43(1):545	NUM
cajgh-4	352	2	-	-	SYM
cajgh-4	352	3	84	84	NUM
cajgh-4	352	4	.	.	PUNCT
cajgh-4	353	1	78	78	NUM
cajgh-4	353	2	.	.	PUNCT
cajgh-4	354	1	mezey	mezey	PROPN
cajgh-4	354	2	e	e	NOUN
cajgh-4	354	3	,	,	PUNCT
cajgh-4	354	4	chandross	chandross	PROPN
cajgh-4	354	5	kj	kj	PROPN
cajgh-4	354	6	,	,	PUNCT
cajgh-4	354	7	harta	harta	PROPN
cajgh-4	354	8	g	g	PROPN
cajgh-4	354	9	,	,	PUNCT
cajgh-4	354	10	maki	maki	PROPN
cajgh-4	354	11	ra	ra	PROPN
cajgh-4	354	12	,	,	PUNCT
cajgh-4	354	13	mckercher	mckercher	PROPN
cajgh-4	354	14	sr	sr	PROPN
cajgh-4	354	15	.	.	PUNCT
cajgh-4	355	1	turning	turn	VERB
cajgh-4	355	2	blood	blood	NOUN
cajgh-4	355	3	into	into	ADP
cajgh-4	355	4	brain	brain	NOUN
cajgh-4	355	5	:	:	PUNCT
cajgh-4	355	6	cells	cell	NOUN
cajgh-4	355	7	bearing	bear	VERB
cajgh-4	355	8	neuronal	neuronal	ADJ
cajgh-4	355	9	antigens	antigen	NOUN
cajgh-4	355	10	generated	generate	VERB
cajgh-4	355	11	in	in	ADP
cajgh-4	355	12	vivo	vivo	NOUN
cajgh-4	355	13	from	from	ADP
cajgh-4	355	14	bone	bone	NOUN
cajgh-4	355	15	marrow	marrow	NOUN
cajgh-4	355	16	.	.	PUNCT
cajgh-4	356	1	science	science	NOUN
cajgh-4	356	2	.	.	PUNCT
cajgh-4	357	1	2000;290(5497):1779	2000;290(5497):1779	NUM
cajgh-4	357	2	-	-	SYM
cajgh-4	357	3	82	82	NUM
cajgh-4	357	4	.	.	PUNCT
cajgh-4	358	1	79	79	NUM
cajgh-4	358	2	.	.	PUNCT
cajgh-4	359	1	giri	giri	PROPN
cajgh-4	359	2	r	r	PROPN
cajgh-4	359	3	,	,	PUNCT
cajgh-4	359	4	selvaraj	selvaraj	PROPN
cajgh-4	359	5	s	s	PROPN
cajgh-4	359	6	,	,	PUNCT
cajgh-4	359	7	miller	miller	PROPN
cajgh-4	359	8	ca	ca	PROPN
cajgh-4	359	9	,	,	PUNCT
cajgh-4	359	10	hofman	hofman	PROPN
cajgh-4	359	11	f	f	PROPN
cajgh-4	359	12	,	,	PUNCT
cajgh-4	359	13	yan	yan	PROPN
cajgh-4	359	14	sd	sd	PROPN
cajgh-4	359	15	,	,	PUNCT
cajgh-4	359	16	stern	stern	PROPN
cajgh-4	359	17	d	d	PROPN
cajgh-4	359	18	,	,	PUNCT
cajgh-4	359	19	et	et	PROPN
cajgh-4	359	20	al	al	PROPN
cajgh-4	359	21	.	.	PROPN
cajgh-4	359	22	effect	effect	NOUN
cajgh-4	359	23	of	of	ADP
cajgh-4	359	24	endothelial	endothelial	ADJ
cajgh-4	359	25	cell	cell	NOUN
cajgh-4	359	26	polarity	polarity	NOUN
cajgh-4	359	27	on	on	ADP
cajgh-4	359	28	beta	beta	ADJ
cajgh-4	359	29	-amyloid	-amyloid	NOUN
cajgh-4	359	30	-	-	PUNCT
cajgh-4	359	31	induced	induce	VERB
cajgh-4	359	32	migration	migration	NOUN
cajgh-4	359	33	of	of	ADP
cajgh-4	359	34	monocytes	monocyte	NOUN
cajgh-4	359	35	across	across	ADP
cajgh-4	359	36	normal	normal	ADJ
cajgh-4	359	37	and	and	CCONJ
cajgh-4	359	38	ad	ad	NOUN
cajgh-4	359	39	endothelium	endothelium	NOUN
cajgh-4	359	40	.	.	PUNCT
cajgh-4	359	41	am	be	AUX
cajgh-4	359	42	j	j	PROPN
cajgh-4	359	43	physiol	physiol	PROPN
cajgh-4	359	44	cell	cell	PROPN
cajgh-4	359	45	physiol	physiol	PROPN
cajgh-4	359	46	.	.	PUNCT
cajgh-4	360	1	2002;283(3):c895	2002;283(3):c895	NUM
cajgh-4	360	2	-	-	SYM
cajgh-4	360	3	904	904	NUM
cajgh-4	360	4	.	.	PUNCT
cajgh-4	361	1	80	80	NUM
cajgh-4	361	2	.	.	PUNCT
cajgh-4	362	1	reyes	reyes	PROPN
cajgh-4	362	2	barcelo	barcelo	PROPN
cajgh-4	362	3	a	a	PROPN
cajgh-4	362	4	,	,	PUNCT
cajgh-4	362	5	gonzalez	gonzalez	PROPN
cajgh-4	362	6	-	-	PUNCT
cajgh-4	362	7	velasquez	velasquez	PROPN
cajgh-4	362	8	f	f	PROPN
cajgh-4	362	9	,	,	PUNCT
cajgh-4	362	10	moss	moss	NOUN
cajgh-4	362	11	m.	m.	NOUN
cajgh-4	362	12	soluble	soluble	ADJ
cajgh-4	362	13	aggregates	aggregate	NOUN
cajgh-4	362	14	of	of	ADP
cajgh-4	362	15	the	the	DET
cajgh-4	362	16	amyloid	amyloid	NOUN
cajgh-4	362	17	-	-	PUNCT
cajgh-4	362	18	beta	beta	NOUN
cajgh-4	362	19	peptide	peptide	NOUN
cajgh-4	362	20	are	be	AUX
cajgh-4	362	21	trapped	trap	VERB
cajgh-4	362	22	by	by	ADP
cajgh-4	362	23	serum	serum	NOUN
cajgh-4	362	24	albumin	albumin	NOUN
cajgh-4	362	25	to	to	PART
cajgh-4	362	26	enhance	enhance	VERB
cajgh-4	362	27	amyloid	amyloid	NOUN
cajgh-4	362	28	-	-	PUNCT
cajgh-4	362	29	beta	beta	NOUN
cajgh-4	362	30	activation	activation	NOUN
cajgh-4	362	31	of	of	ADP
cajgh-4	362	32	endothelial	endothelial	ADJ
cajgh-4	362	33	cells	cell	NOUN
cajgh-4	362	34	.	.	PUNCT
cajgh-4	363	1	journal	journal	NOUN
cajgh-4	363	2	of	of	ADP
cajgh-4	363	3	biological	biological	ADJ
cajgh-4	363	4	engineering	engineering	NOUN
cajgh-4	363	5	.	.	PUNCT
cajgh-4	364	1	2009;3(1):5	2009;3(1):5	NOUN
cajgh-4	364	2	.	.	PUNCT
cajgh-4	365	1	81	81	NUM
cajgh-4	365	2	.	.	PUNCT
cajgh-4	366	1	gonzalez	gonzalez	PROPN
cajgh-4	366	2	-	-	PUNCT
cajgh-4	366	3	velasquez	velasquez	PROPN
cajgh-4	366	4	fj	fj	PROPN
cajgh-4	366	5	,	,	PUNCT
cajgh-4	366	6	kotarek	kotarek	PROPN
cajgh-4	366	7	ja	ja	PROPN
cajgh-4	366	8	,	,	PUNCT
cajgh-4	366	9	moss	moss	PROPN
cajgh-4	366	10	ma	ma	PROPN
cajgh-4	366	11	.	.	PROPN
cajgh-4	366	12	soluble	soluble	ADJ
cajgh-4	366	13	aggregates	aggregate	NOUN
cajgh-4	366	14	of	of	ADP
cajgh-4	366	15	the	the	DET
cajgh-4	366	16	amyloid	amyloid	NOUN
cajgh-4	366	17	-	-	PUNCT
cajgh-4	366	18	beta	beta	NOUN
cajgh-4	366	19	protein	protein	NOUN
cajgh-4	366	20	selectively	selectively	ADV
cajgh-4	366	21	stimulate	stimulate	VERB
cajgh-4	366	22	permeability	permeability	NOUN
cajgh-4	366	23	in	in	ADP
cajgh-4	366	24	human	human	ADJ
cajgh-4	366	25	brain	brain	NOUN
cajgh-4	366	26	microvascular	microvascular	NOUN
cajgh-4	366	27	endothelial	endothelial	ADJ
cajgh-4	366	28	monolayers	monolayer	NOUN
cajgh-4	366	29	.	.	PUNCT
cajgh-4	367	1	j	j	PROPN
cajgh-4	367	2	neurochem	neurochem	PROPN
cajgh-4	367	3	.	.	PUNCT
cajgh-4	368	1	2008;107:466	2008;107:466	NUM
cajgh-4	368	2	-	-	SYM
cajgh-4	368	3	77	77	NUM
cajgh-4	368	4	.	.	PUNCT
cajgh-4	369	1	82	82	NUM
cajgh-4	369	2	.	.	PUNCT
cajgh-4	370	1	frijns	frijns	PROPN
cajgh-4	370	2	cj	cj	PROPN
cajgh-4	370	3	,	,	PUNCT
cajgh-4	370	4	kappelle	kappelle	PROPN
cajgh-4	370	5	lj	lj	PROPN
cajgh-4	370	6	.	.	PUNCT
cajgh-4	370	7	inflammatory	inflammatory	ADJ
cajgh-4	370	8	cell	cell	NOUN
cajgh-4	370	9	adhesion	adhesion	NOUN
cajgh-4	370	10	molecules	molecule	NOUN
cajgh-4	370	11	in	in	ADP
cajgh-4	370	12	ischemic	ischemic	ADJ
cajgh-4	370	13	cerebrovascular	cerebrovascular	ADJ
cajgh-4	370	14	disease	disease	NOUN
cajgh-4	370	15	.	.	PUNCT
cajgh-4	371	1	stroke	stroke	NOUN
cajgh-4	371	2	.	.	PUNCT
cajgh-4	372	1	2002;33(8):2115	2002;33(8):2115	PROPN
cajgh-4	372	2	-	-	SYM
cajgh-4	372	3	22	22	NUM
cajgh-4	372	4	.	.	PUNCT
cajgh-4	373	1	83	83	NUM
cajgh-4	373	2	.	.	PUNCT
cajgh-4	374	1	alon	alon	PROPN
cajgh-4	374	2	r	r	PROPN
cajgh-4	374	3	,	,	PUNCT
cajgh-4	374	4	chen	chen	PROPN
cajgh-4	374	5	s	s	PROPN
cajgh-4	374	6	,	,	PUNCT
cajgh-4	374	7	puri	puri	PROPN
cajgh-4	374	8	kd	kd	PROPN
cajgh-4	374	9	,	,	PUNCT
cajgh-4	374	10	finger	finger	PROPN
cajgh-4	374	11	eb	eb	PROPN
cajgh-4	374	12	,	,	PUNCT
cajgh-4	374	13	springer	springer	NOUN
cajgh-4	374	14	ta	ta	PROPN
cajgh-4	374	15	.	.	PUNCT
cajgh-4	375	1	the	the	DET
cajgh-4	375	2	kinetics	kinetic	NOUN
cajgh-4	375	3	of	of	ADP
cajgh-4	375	4	l	l	NOUN
cajgh-4	375	5	-	-	ADJ
cajgh-4	375	6	selectin	selectin	ADJ
cajgh-4	375	7	tethers	tether	NOUN
cajgh-4	375	8	and	and	CCONJ
cajgh-4	375	9	the	the	DET
cajgh-4	375	10	mechanics	mechanic	NOUN
cajgh-4	375	11	of	of	ADP
cajgh-4	375	12	selectin	selectin	NOUN
cajgh-4	375	13	-	-	PUNCT
cajgh-4	375	14	mediated	mediate	VERB
cajgh-4	375	15	rolling	rolling	NOUN
cajgh-4	375	16	.	.	PUNCT
cajgh-4	376	1	j	j	PROPN
cajgh-4	376	2	cell	cell	PROPN
cajgh-4	376	3	biol	biol	PROPN
cajgh-4	376	4	.	.	PUNCT
cajgh-4	377	1	1997;138(5):1169	1997;138(5):1169	NUM
cajgh-4	377	2	-	-	SYM
cajgh-4	377	3	80	80	NUM
cajgh-4	377	4	.	.	PUNCT
cajgh-4	378	1	84	84	NUM
cajgh-4	378	2	.	.	PUNCT
cajgh-4	379	1	alon	alon	PROPN
cajgh-4	379	2	r	r	PROPN
cajgh-4	379	3	,	,	PUNCT
cajgh-4	379	4	hammer	hammer	NOUN
cajgh-4	379	5	da	da	NOUN
cajgh-4	379	6	,	,	PUNCT
cajgh-4	379	7	springer	springer	NOUN
cajgh-4	379	8	ta	ta	PROPN
cajgh-4	379	9	.	.	PUNCT
cajgh-4	379	10	lifetime	lifetime	NOUN
cajgh-4	379	11	of	of	ADP
cajgh-4	379	12	the	the	DET
cajgh-4	379	13	p	p	NOUN
cajgh-4	379	14	-	-	PUNCT
cajgh-4	379	15	selectin	selectin	ADJ
cajgh-4	379	16	-	-	PUNCT
cajgh-4	379	17	carbohydrate	carbohydrate	NOUN
cajgh-4	379	18	bond	bond	NOUN
cajgh-4	379	19	and	and	CCONJ
cajgh-4	379	20	its	its	PRON
cajgh-4	379	21	response	response	NOUN
cajgh-4	379	22	to	to	PART
cajgh-4	379	23	tensile	tensile	VERB
cajgh-4	379	24	force	force	NOUN
cajgh-4	379	25	in	in	ADP
cajgh-4	379	26	hydrodynamic	hydrodynamic	ADJ
cajgh-4	379	27	flow	flow	NOUN
cajgh-4	379	28	.	.	PUNCT
cajgh-4	380	1	nature	nature	NOUN
cajgh-4	380	2	.	.	PUNCT
cajgh-4	381	1	1995;374(6522):539	1995;374(6522):539	NUM
cajgh-4	381	2	-	-	SYM
cajgh-4	381	3	42	42	NUM
cajgh-4	381	4	.	.	PUNCT
cajgh-4	381	5	85	85	NUM
cajgh-4	381	6	.	.	PUNCT
cajgh-4	382	1	dembo	dembo	PROPN
cajgh-4	382	2	m	m	PROPN
cajgh-4	382	3	,	,	PUNCT
cajgh-4	382	4	torney	torney	PROPN
cajgh-4	382	5	dc	dc	PROPN
cajgh-4	382	6	,	,	PUNCT
cajgh-4	382	7	saxman	saxman	PROPN
cajgh-4	382	8	k	k	PROPN
cajgh-4	382	9	,	,	PUNCT
cajgh-4	382	10	hammer	hammer	PROPN
cajgh-4	382	11	d.	d.	PROPN
cajgh-4	382	12	the	the	DET
cajgh-4	382	13	reaction	reaction	NOUN
cajgh-4	382	14	-	-	PUNCT
cajgh-4	382	15	limited	limit	VERB
cajgh-4	382	16	kinetics	kinetic	NOUN
cajgh-4	382	17	of	of	ADP
cajgh-4	382	18	membrane	membrane	NOUN
cajgh-4	382	19	-	-	PUNCT
cajgh-4	382	20	to	to	ADP
cajgh-4	382	21	-	-	PUNCT
cajgh-4	382	22	surface	surface	NOUN
cajgh-4	382	23	adhesion	adhesion	NOUN
cajgh-4	382	24	and	and	CCONJ
cajgh-4	382	25	detachment	detachment	NOUN
cajgh-4	382	26	.	.	PUNCT
cajgh-4	383	1	proc	proc	NOUN
cajgh-4	383	2	r	r	PROPN
cajgh-4	383	3	soc	soc	PROPN
cajgh-4	383	4	lond	lond	PROPN
cajgh-4	383	5	b	b	PROPN
cajgh-4	383	6	biol	biol	NOUN
cajgh-4	383	7	sci.1988;234(1274):55	sci.1988;234(1274):55	NOUN
cajgh-4	383	8	-	-	PUNCT
cajgh-4	383	9	83	83	NUM
cajgh-4	383	10	.	.	PUNCT
cajgh-4	383	11	86	86	NUM
cajgh-4	383	12	.	.	PUNCT
cajgh-4	383	13	trache	trache	PROPN
cajgh-4	384	1	a	a	PRON
cajgh-4	384	2	,	,	PUNCT
cajgh-4	384	3	trzeciakowski	trzeciakowski	PROPN
cajgh-4	384	4	jp	jp	PROPN
cajgh-4	384	5	,	,	PUNCT
cajgh-4	384	6	gardiner	gardiner	PROPN
cajgh-4	384	7	l	l	PROPN
cajgh-4	384	8	,	,	PUNCT
cajgh-4	384	9	sun	sun	PROPN
cajgh-4	384	10	z	z	PROPN
cajgh-4	384	11	,	,	PUNCT
cajgh-4	384	12	muthuchamy	muthuchamy	PROPN
cajgh-4	384	13	m	m	PROPN
cajgh-4	384	14	,	,	PUNCT
cajgh-4	384	15	guo	guo	PROPN
cajgh-4	384	16	m	m	PROPN
cajgh-4	384	17	,	,	PUNCT
cajgh-4	384	18	et	et	PROPN
cajgh-4	384	19	al	al	PROPN
cajgh-4	384	20	.	.	PUNCT
cajgh-4	385	1	histamine	histamine	NOUN
cajgh-4	385	2	effects	effect	NOUN
cajgh-4	385	3	on	on	ADP
cajgh-4	385	4	endothelial	endothelial	ADJ
cajgh-4	385	5	cell	cell	NOUN
cajgh-4	385	6	fibronectin	fibronectin	NOUN
cajgh-4	385	7	interaction	interaction	NOUN
cajgh-4	385	8	studied	study	VERB
cajgh-4	385	9	by	by	ADP
cajgh-4	385	10	atomic	atomic	ADJ
cajgh-4	385	11	force	force	NOUN
cajgh-4	385	12	microscopy	microscopy	NOUN
cajgh-4	385	13	.	.	PUNCT
cajgh-4	386	1	biophys	biophys	PROPN
cajgh-4	386	2	j.	j.	PROPN
cajgh-4	386	3	2005;89(4):2888	2005;89(4):2888	PROPN
cajgh-4	386	4	-	-	SYM
cajgh-4	386	5	98	98	NUM
cajgh-4	386	6	.	.	PUNCT
cajgh-4	387	1	87	87	NUM
cajgh-4	387	2	.	.	PUNCT
cajgh-4	388	1	sun	sun	PROPN
cajgh-4	388	2	m	m	PROPN
cajgh-4	388	3	,	,	PUNCT
cajgh-4	388	4	northup	northup	PROPN
cajgh-4	388	5	n	n	CCONJ
cajgh-4	388	6	,	,	PUNCT
cajgh-4	388	7	marga	marga	PROPN
cajgh-4	388	8	f	f	PROPN
cajgh-4	388	9	,	,	PUNCT
cajgh-4	388	10	huber	huber	PROPN
cajgh-4	388	11	t	t	PROPN
cajgh-4	388	12	,	,	PUNCT
cajgh-4	388	13	byfield	byfield	PROPN
cajgh-4	388	14	fj	fj	PROPN
cajgh-4	388	15	,	,	PUNCT
cajgh-4	388	16	levitan	levitan	PROPN
cajgh-4	388	17	i	i	PRON
cajgh-4	388	18	,	,	PUNCT
cajgh-4	388	19	et	et	PROPN
cajgh-4	388	20	al	al	PROPN
cajgh-4	388	21	.	.	PUNCT
cajgh-4	389	1	the	the	DET
cajgh-4	389	2	effect	effect	NOUN
cajgh-4	389	3	of	of	ADP
cajgh-4	389	4	cellular	cellular	ADJ
cajgh-4	389	5	cholesterol	cholesterol	NOUN
cajgh-4	389	6	on	on	ADP
cajgh-4	389	7	membrane	membrane	NOUN
cajgh-4	389	8	-	-	PUNCT
cajgh-4	389	9	cytoskeleton	cytoskeleton	NOUN
cajgh-4	389	10	adhesion	adhesion	NOUN
cajgh-4	389	11	.	.	PUNCT
cajgh-4	390	1	j	j	PROPN
cajgh-4	390	2	cell	cell	PROPN
cajgh-4	390	3	sci	sci	PROPN
cajgh-4	390	4	.	.	PUNCT
cajgh-4	391	1	2007;120(13):2223	2007;120(13):2223	NUM
cajgh-4	391	2	-	-	SYM
cajgh-4	391	3	31	31	NUM
cajgh-4	391	4	.	.	PUNCT
cajgh-4	392	1	88	88	NUM
cajgh-4	392	2	.	.	PUNCT
cajgh-4	393	1	sun	sun	PROPN
cajgh-4	393	2	m	m	PROPN
cajgh-4	393	3	,	,	PUNCT
cajgh-4	393	4	graham	graham	PROPN
cajgh-4	393	5	js	js	PROPN
cajgh-4	393	6	,	,	PUNCT
cajgh-4	393	7	hegedьs	hegedьs	PROPN
cajgh-4	393	8	b	b	PROPN
cajgh-4	393	9	,	,	PUNCT
cajgh-4	393	10	marga	marga	PROPN
cajgh-4	393	11	f	f	PROPN
cajgh-4	393	12	,	,	PUNCT
cajgh-4	393	13	zhang	zhang	PROPN
cajgh-4	393	14	y	y	PROPN
cajgh-4	393	15	,	,	PUNCT
cajgh-4	393	16	forgacs	forgacs	PROPN
cajgh-4	393	17	g	g	PROPN
cajgh-4	393	18	,	,	PUNCT
cajgh-4	393	19	et	et	PROPN
cajgh-4	393	20	al	al	PROPN
cajgh-4	393	21	.	.	PUNCT
cajgh-4	393	22	multiple	multiple	ADJ
cajgh-4	393	23	membrane	membrane	NOUN
cajgh-4	393	24	tethers	tether	NOUN
cajgh-4	393	25	probed	probe	VERB
cajgh-4	393	26	by	by	ADP
cajgh-4	393	27	atomic	atomic	ADJ
cajgh-4	393	28	force	force	NOUN
cajgh-4	393	29	microscopy	microscopy	NOUN
cajgh-4	393	30	.	.	PUNCT
cajgh-4	394	1	2005;89(6):4320	2005;89(6):4320	NUM
cajgh-4	394	2	-	-	SYM
cajgh-4	394	3	9	9	NUM
cajgh-4	394	4	.	.	NOUN
cajgh-4	394	5	89	89	NUM
cajgh-4	394	6	.	.	PUNCT
cajgh-4	395	1	girdhar	girdhar	PROPN
cajgh-4	395	2	g	g	PROPN
cajgh-4	395	3	,	,	PUNCT
cajgh-4	395	4	shao	shao	PROPN
cajgh-4	395	5	j	j	PROPN
cajgh-4	395	6	-	-	PUNCT
cajgh-4	395	7	y.	y.	PROPN
cajgh-4	395	8	membrane	membrane	NOUN
cajgh-4	395	9	tether	tether	NOUN
cajgh-4	395	10	extraction	extraction	NOUN
cajgh-4	395	11	from	from	ADP
cajgh-4	395	12	human	human	ADJ
cajgh-4	395	13	umbilical	umbilical	ADJ
cajgh-4	395	14	vein	vein	ADJ
cajgh-4	395	15	endothelial	endothelial	NOUN
cajgh-4	395	16	cells	cell	NOUN
cajgh-4	395	17	and	and	CCONJ
cajgh-4	395	18	its	its	PRON
cajgh-4	395	19	implication	implication	NOUN
cajgh-4	395	20	in	in	ADP
cajgh-4	395	21	leukocyte	leukocyte	NOUN
cajgh-4	395	22	rolling	rolling	NOUN
cajgh-4	395	23	.	.	PUNCT
cajgh-4	396	1	biophysical	biophysical	ADJ
cajgh-4	396	2	journal	journal	NOUN
cajgh-4	396	3	.	.	PUNCT
cajgh-4	397	1	2004;87(5):3561	2004;87(5):3561	NUM
cajgh-4	397	2	-	-	SYM
cajgh-4	397	3	8	8	NUM
cajgh-4	397	4	.	.	X
cajgh-4	397	5	90	90	NUM
cajgh-4	397	6	.	.	PUNCT
cajgh-4	398	1	girdhar	girdhar	PROPN
cajgh-4	398	2	g	g	PROPN
cajgh-4	398	3	,	,	PUNCT
cajgh-4	398	4	chen	chen	PROPN
cajgh-4	398	5	y	y	PROPN
cajgh-4	398	6	,	,	PUNCT
cajgh-4	398	7	shao	shao	PROPN
cajgh-4	398	8	j	j	PROPN
cajgh-4	398	9	-	-	PROPN
cajgh-4	398	10	y.	y.	PROPN
cajgh-4	398	11	double	double	ADJ
cajgh-4	398	12	-	-	PUNCT
cajgh-4	398	13	tether	tether	NOUN
cajgh-4	398	14	extraction	extraction	NOUN
cajgh-4	398	15	from	from	ADP
cajgh-4	398	16	human	human	ADJ
cajgh-4	398	17	umbilical	umbilical	ADJ
cajgh-4	398	18	vein	vein	NOUN
cajgh-4	398	19	and	and	CCONJ
cajgh-4	398	20	dermal	dermal	VERB
cajgh-4	398	21	microvascular	microvascular	ADJ
cajgh-4	398	22	endothelial	endothelial	ADJ
cajgh-4	398	23	cells	cell	NOUN
cajgh-4	398	24	.	.	PUNCT
cajgh-4	399	1	biophysical	biophysical	ADJ
cajgh-4	399	2	journal	journal	NOUN
cajgh-4	399	3	.	.	PUNCT
cajgh-4	400	1	007;92(3):1035	007;92(3):1035	NUM
cajgh-4	400	2	-	-	SYM
cajgh-4	400	3	45	45	NUM
cajgh-4	400	4	.	.	NOUN
cajgh-4	400	5	91	91	NUM
cajgh-4	400	6	.	.	PUNCT
cajgh-4	401	1	lee	lee	PROPN
cajgh-4	401	2	jcm	jcm	PROPN
cajgh-4	401	3	,	,	PUNCT
cajgh-4	401	4	askarova	askarova	PROPN
cajgh-4	401	5	s	s	X
cajgh-4	401	6	,	,	PUNCT
cajgh-4	401	7	sun	sun	PROPN
cajgh-4	401	8	z	z	PROPN
cajgh-4	401	9	,	,	PUNCT
cajgh-4	401	10	sun	sun	PROPN
cajgh-4	401	11	gy	gy	PROPN
cajgh-4	401	12	,	,	PUNCT
cajgh-4	401	13	meininger	meininger	PROPN
cajgh-4	401	14	ga	ga	PROPN
cajgh-4	401	15	.	.	PUNCT
cajgh-4	401	16	p4	p4	PROPN
cajgh-4	401	17	-	-	PUNCT
cajgh-4	401	18	293	293	NUM
cajgh-4	401	19	:	:	PUNCT
cajgh-4	401	20	oligomeric	oligomeric	ADJ
cajgh-4	401	21	amyloid	amyloid	NOUN
cajgh-4	401	22	-	-	PUNCT
cajgh-4	401	23	оі	оі	NOUN
cajgh-4	401	24	peptide	peptide	NOUN
cajgh-4	401	25	on	on	ADP
cajgh-4	401	26	sialyl	sialyl	ADJ
cajgh-4	401	27	lewisx	lewisx	NOUN
cajgh-4	401	28	-	-	PUNCT
cajgh-4	401	29	selectin	selectin	NOUN
cajgh-4	401	30	bonding	bonding	NOUN
cajgh-4	401	31	at	at	ADP
cajgh-4	401	32	the	the	DET
cajgh-4	401	33	cerebral	cerebral	ADJ
cajgh-4	401	34	endothelial	endothelial	ADJ
cajgh-4	401	35	cell	cell	NOUN
cajgh-4	401	36	surface	surface	NOUN
cajgh-4	401	37	.	.	PUNCT
cajgh-4	402	1	alzheimer	alzheimer	PROPN
cajgh-4	402	2	's	's	PART
cajgh-4	402	3	&	&	CCONJ
cajgh-4	402	4	dementia	dementia	PROPN
cajgh-4	402	5	:	:	PUNCT
cajgh-4	402	6	the	the	DET
cajgh-4	402	7	journal	journal	NOUN
cajgh-4	402	8	of	of	ADP
cajgh-4	402	9	the	the	DET
cajgh-4	402	10	alzheimer	alzheimer	PROPN
cajgh-4	402	11	's	's	PART
cajgh-4	402	12	association	association	NOUN
cajgh-4	402	13	.	.	PUNCT
cajgh-4	403	1	2008;4(4):t757	2008;4(4):t757	NOUN
cajgh-4	403	2	.	.	PUNCT
cajgh-4	404	1	92	92	NUM
cajgh-4	404	2	.	.	PUNCT
cajgh-4	405	1	bednarczyk	bednarczyk	PROPN
cajgh-4	405	2	j	j	PROPN
cajgh-4	405	3	,	,	PUNCT
cajgh-4	405	4	lukasiuk	lukasiuk	PROPN
cajgh-4	405	5	k.	k.	PROPN
cajgh-4	405	6	tight	tight	PROPN
cajgh-4	405	7	junctions	junction	NOUN
cajgh-4	405	8	in	in	ADP
cajgh-4	405	9	neurological	neurological	ADJ
cajgh-4	405	10	diseases	disease	NOUN
cajgh-4	405	11	.	.	PUNCT
cajgh-4	406	1	acta	acta	PROPN
cajgh-4	406	2	neurobiol	neurobiol	PROPN
cajgh-4	406	3	exp	exp	PROPN
cajgh-4	406	4	.	.	PUNCT
cajgh-4	407	1	2011;71(4):393	2011;71(4):393	PROPN
cajgh-4	407	2	-	-	PUNCT
cajgh-4	407	3	408	408	NUM
cajgh-4	407	4	.	.	PUNCT
cajgh-4	408	1	93	93	NUM
cajgh-4	408	2	.	.	PUNCT
cajgh-4	409	1	chen	chen	PROPN
cajgh-4	409	2	x	x	PROPN
cajgh-4	409	3	,	,	PUNCT
cajgh-4	409	4	gawryluk	gawryluk	PROPN
cajgh-4	409	5	j	j	PROPN
cajgh-4	409	6	,	,	PUNCT
cajgh-4	409	7	wagener	wagener	PROPN
cajgh-4	409	8	j	j	PROPN
cajgh-4	409	9	,	,	PUNCT
cajgh-4	409	10	ghribi	ghribi	PROPN
cajgh-4	409	11	o	o	PROPN
cajgh-4	409	12	,	,	PUNCT
cajgh-4	409	13	geiger	geiger	PROPN
cajgh-4	409	14	j.	j.	PROPN
cajgh-4	409	15	caffeine	caffeine	PROPN
cajgh-4	409	16	blocks	block	VERB
cajgh-4	409	17	disruption	disruption	NOUN
cajgh-4	409	18	of	of	ADP
cajgh-4	409	19	blood	blood	NOUN
cajgh-4	409	20	brain	brain	NOUN
cajgh-4	409	21	barrier	barrier	NOUN
cajgh-4	409	22	in	in	ADP
cajgh-4	409	23	a	a	DET
cajgh-4	409	24	rabbit	rabbit	NOUN
cajgh-4	409	25	model	model	NOUN
cajgh-4	409	26	of	of	ADP
cajgh-4	409	27	alzheimer	alzheimer	PROPN
cajgh-4	409	28	's	's	PART
cajgh-4	409	29	disease	disease	NOUN
cajgh-4	409	30	.	.	PUNCT
cajgh-4	410	1	journal	journal	PROPN
cajgh-4	410	2	of	of	ADP
cajgh-4	410	3	neuroinflammation	neuroinflammation	NOUN
cajgh-4	410	4	.	.	PUNCT
cajgh-4	411	1	2008;5(1):12	2008;5(1):12	NUM
cajgh-4	411	2	.	.	NOUN
cajgh-4	411	3	94	94	NUM
cajgh-4	411	4	.	.	PUNCT
cajgh-4	412	1	marco	marco	PROPN
cajgh-4	412	2	s	s	PROPN
cajgh-4	412	3	,	,	PUNCT
cajgh-4	412	4	skaper	skaper	NOUN
cajgh-4	412	5	sd	sd	NOUN
cajgh-4	412	6	.	.	PUNCT
cajgh-4	413	1	amyloid	amyloid	NOUN
cajgh-4	413	2	[	[	X
cajgh-4	413	3	beta]-peptide1	beta]-peptide1	ADV
cajgh-4	413	4	-	-	PUNCT
cajgh-4	413	5	42	42	NUM
cajgh-4	413	6	alters	alter	VERB
cajgh-4	413	7	tight	tight	ADJ
cajgh-4	413	8	junction	junction	NOUN
cajgh-4	413	9	protein	protein	NOUN
cajgh-4	413	10	distribution	distribution	NOUN
cajgh-4	413	11	and	and	CCONJ
cajgh-4	413	12	expression	expression	NOUN
cajgh-4	413	13	in	in	ADP
cajgh-4	413	14	brain	brain	NOUN
cajgh-4	413	15	microvessel	microvessel	NOUN
cajgh-4	413	16	endothelial	endothelial	ADJ
cajgh-4	413	17	cells	cell	NOUN
cajgh-4	413	18	.	.	PUNCT
cajgh-4	414	1	neuroscience	neuroscience	NOUN
cajgh-4	414	2	letters	letter	NOUN
cajgh-4	414	3	.	.	PUNCT
cajgh-4	415	1	2006;401(3):219	2006;401(3):219	NUM
cajgh-4	415	2	-	-	SYM
cajgh-4	415	3	24	24	NUM
cajgh-4	415	4	.	.	PUNCT
cajgh-4	415	5	95	95	NUM
cajgh-4	415	6	.	.	PUNCT
cajgh-4	416	1	nishitsuji	nishitsuji	PROPN
cajgh-4	416	2	k	k	PROPN
cajgh-4	416	3	,	,	PUNCT
cajgh-4	416	4	hosono	hosono	PROPN
cajgh-4	416	5	t	t	PROPN
cajgh-4	416	6	,	,	PUNCT
cajgh-4	416	7	nakamura	nakamura	PROPN
cajgh-4	416	8	t	t	PROPN
cajgh-4	416	9	,	,	PUNCT
cajgh-4	416	10	bu	bu	ADP
cajgh-4	416	11	g	g	NOUN
cajgh-4	416	12	,	,	PUNCT
cajgh-4	416	13	m.	m.	NOUN
cajgh-4	416	14	m.	m.	NOUN
cajgh-4	416	15	apolipoprotein	apolipoprotein	PROPN
cajgh-4	416	16	e	e	PROPN
cajgh-4	416	17	regulates	regulate	VERB
cajgh-4	416	18	the	the	DET
cajgh-4	416	19	integrity	integrity	NOUN
cajgh-4	416	20	of	of	ADP
cajgh-4	416	21	tight	tight	ADJ
cajgh-4	416	22	junctions	junction	NOUN
cajgh-4	416	23	in	in	ADP
cajgh-4	416	24	an	an	DET
cajgh-4	416	25	isoform	isoform	NOUN
cajgh-4	416	26	-	-	PUNCT
cajgh-4	416	27	dependent	dependent	ADJ
cajgh-4	416	28	manner	manner	NOUN
cajgh-4	416	29	in	in	ADP
cajgh-4	416	30	an	an	DET
cajgh-4	416	31	in	in	X
cajgh-4	416	32	vitro	vitro	X
cajgh-4	416	33	blood	blood	NOUN
cajgh-4	416	34	-	-	PUNCT
cajgh-4	416	35	brain	brain	NOUN
cajgh-4	416	36	barrier	barrier	NOUN
cajgh-4	416	37	model	model	NOUN
cajgh-4	416	38	.	.	PUNCT
cajgh-4	417	1	j	j	PROPN
cajgh-4	417	2	biol	biol	PROPN
cajgh-4	417	3	chem	chem	NOUN
cajgh-4	417	4	.	.	PUNCT
cajgh-4	418	1	2011;286(20):17536	2011;286(20):17536	NUM
cajgh-4	418	2	-	-	SYM
cajgh-4	418	3	4	4	NUM
cajgh-4	418	4	.	.	NOUN
cajgh-4	419	1	96	96	NUM
cajgh-4	419	2	.	.	PUNCT
cajgh-4	420	1	omolola	omolola	PROPN
cajgh-4	420	2	eniola	eniola	PROPN
cajgh-4	420	3	a	a	DET
cajgh-4	420	4	,	,	PUNCT
cajgh-4	420	5	hammer	hammer	NOUN
cajgh-4	420	6	da	da	NOUN
cajgh-4	420	7	.	.	PUNCT
cajgh-4	421	1	in	in	ADP
cajgh-4	421	2	vitro	vitro	X
cajgh-4	421	3	characterization	characterization	NOUN
cajgh-4	421	4	of	of	ADP
cajgh-4	421	5	leukocyte	leukocyte	NOUN
cajgh-4	421	6	mimetic	mimetic	NOUN
cajgh-4	421	7	for	for	ADP
cajgh-4	421	8	targeting	target	VERB
cajgh-4	421	9	therapeutics	therapeutic	NOUN
cajgh-4	421	10	to	to	ADP
cajgh-4	421	11	the	the	DET
cajgh-4	421	12	endothelium	endothelium	NOUN
cajgh-4	421	13	using	use	VERB
cajgh-4	421	14	two	two	NUM
cajgh-4	421	15	receptors	receptor	NOUN
cajgh-4	421	16	.	.	PUNCT
cajgh-4	422	1	biomaterials	biomaterial	NOUN
cajgh-4	422	2	.	.	PUNCT
cajgh-4	423	1	2005;26(34):7136	2005;26(34):7136	NUM
cajgh-4	423	2	-	-	SYM
cajgh-4	423	3	44	44	NUM
cajgh-4	423	4	.	.	PUNCT